FN Thomson Reuters Web of Science™ VR 1.0 PT J AU Wang, GX Pandey, R Karna, SP AF Wang, Gaoxue Pandey, Ravindra Karna, Shashi P. TI Effects of extrinsic point defects in phosphorene: B, C, N, O, and F adatoms SO APPLIED PHYSICS LETTERS LA English DT Article ID LAYER BLACK PHOSPHORUS; FIELD-EFFECT TRANSISTORS; SILICENE; MONOLAYER AB Phosphorene is emerging as a promising 2D semiconducting material with a direct band gap and high carrier mobility. In this paper, we examine the role of the extrinsic point defects including surface adatoms in modifying the electronic properties of phosphorene using density functional theory. The surface adatoms considered are B, C, N, O, and F with a [He] core electronic configuration. Our calculations show that B and C, with electronegativity close to P, prefer to break the sp 3 bonds of phosphorene and reside at the interstitial sites in the 2D lattice by forming sp 2 like bonds with the native atoms. On the other hand, N, O, and F, which are more electronegative than P, prefer the surface sites by attracting the lone pairs of phosphorene. B, N, and F adsorption will also introduce local magnetic moment to the lattice. Moreover, B, C, N, and F adatoms will modify the band gap of phosphorene, yielding metallic transverse tunneling characters. Oxygen does not modify the band gap of phosphorene, and a diode like tunneling behavior is observed. Our results therefore offer a possible route to tailor the electronic and magnetic properties of phosphorene by the adatom functionalization and provide the physical insights of the environmental sensitivity of phosphorene, which will be helpful to experimentalists in evaluating the performance and aging effects of phosphorene-based electronic devices. (C) 2015 AIP Publishing LLC. C1 [Wang, Gaoxue; Pandey, Ravindra] Michigan Technol Univ, Dept Phys, Houghton, MI 49931 USA. [Karna, Shashi P.] US Army Res Lab, Weap & Mat Res Directorate, ATTN RDRL WM, Aberdeen Proving Ground, MD 21005 USA. RP Wang, GX (reprint author), Michigan Technol Univ, Dept Phys, Houghton, MI 49931 USA. EM gaoxuew@mtu.edu; pandey@mtu.edu; shashi.p.karna.civ@mail.mil RI Wang, Gaoxue/C-9492-2017 OI Wang, Gaoxue/0000-0003-2539-3405 FU Army Research Office [W911NF-14-2-0088] FX The authors are grateful to Dr. S. Gowtham for his support. This research was partially supported by the Army Research Office through Grant No. W911NF-14-2-0088. RAMA and Superior, high performance computing clusters at Michigan Technological University, were used in obtaining results presented in this paper. NR 42 TC 24 Z9 24 U1 9 U2 105 PU AMER INST PHYSICS PI MELVILLE PA 1305 WALT WHITMAN RD, STE 300, MELVILLE, NY 11747-4501 USA SN 0003-6951 EI 1077-3118 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD APR 27 PY 2015 VL 106 IS 17 AR 173104 DI 10.1063/1.4919389 PG 5 WC Physics, Applied SC Physics GA CH2ES UT WOS:000353839100047 ER PT J AU Welkos, SL Klimko, CP Kern, SJ Bearss, JJ Bozue, JA Bernhards, RC Trevino, SR Waag, DM Amemiya, K Worsham, PL Cote, CK AF Welkos, Susan L. Klimko, Christopher P. Kern, Steven J. Bearss, Jeremy J. Bozue, Joel A. Bernhards, Robert C. Trevino, Sylvia R. Waag, David M. Amemiya, Kei Worsham, Patricia L. Cote, Christopher K. TI Characterization of Burkholderia pseudomallei Strains Using a Murine Intraperitoneal Infection Model and In Vitro Macrophage Assays SO PLOS ONE LA English DT Article ID EXPERIMENTAL MELIOIDOSIS; CAPSULAR POLYSACCHARIDE; INTRACELLULAR SURVIVAL; COLONY MORPHOLOGY; YERSINIA-PESTIS; PULMONARY MELIOIDOSIS; VIRULENCE FACTORS; B. THAILANDENSIS; RISK-FACTORS; LIPOPOLYSACCHARIDE AB Burkholderia pseudomallei, the etiologic agent of melioidosis, is a gram-negative facultative intracellular bacterium. This bacterium is endemic in Southeast Asia and Northern Australia and can infect humans and animals by several routes. It has also been estimated to present a considerable risk as a potential biothreat agent. There are currently no effective vaccines for B. pseudomallei, and antibiotic treatment can be hampered by nonspecific symptomology, the high incidence of naturally occurring antibiotic resistant strains, and disease chronicity. Accordingly, there is a concerted effort to better characterize B. pseudomallei and its associated disease. Before novel vaccines and therapeutics can be tested in vivo, a well characterized animal model is essential. Previous work has indicated that mice may be a useful animal model. In order to develop standardized animal models of melioidosis, different strains of bacteria must be isolated, propagated, and characterized. Using a murine intraperitoneal (IP) infection model, we tested the virulence of 11 B. pseudomallei strains. The IP route offers a reproducible way to rank virulence that can be readily reproduced by other laboratories. This infection route is also useful in distinguishing significant differences in strain virulence that may be masked by the exquisite susceptibility associated with other routes of infection (e.g., inhalational). Additionally, there were several pathologic lesions observed in mice following IP infection. These included varisized abscesses in the spleen, liver, and haired skin. This model indicated that commonly used laboratory strains of B. pseudomallei (i.e., K96243 and 1026b) were significantly less virulent as compared to more recently acquired clinical isolates. Additionally, we characterized in vitro strain-associated differences in virulence for macrophages and described a potential inverse relationship between virulence in the IP mouse model of some strains and in the macrophage phagocytosis assay. Strains which were more virulent for mice (e.g., HBPU10304a) were often less virulent in the macrophage assays, as determined by several parameters such as intracellular bacterial replication and host cell cytotoxicity. C1 [Welkos, Susan L.; Klimko, Christopher P.; Bozue, Joel A.; Bernhards, Robert C.; Trevino, Sylvia R.; Waag, David M.; Amemiya, Kei; Worsham, Patricia L.; Cote, Christopher K.] US Army, Med Res Inst Infect Dis, Bacteriol Div, Frederick, MD 21701 USA. [Kern, Steven J.] US Army, Med Res Inst Infect Dis, Div Biostat, Frederick, MD USA. [Bearss, Jeremy J.] US Army, Med Res Inst Infect Dis, Vet Pathol Div, Frederick, MD USA. RP Cote, CK (reprint author), US Army, Med Res Inst Infect Dis, Bacteriol Div, Frederick, MD 21701 USA. EM christopher.k.cote.civ@mail.mil OI Bearss, David/0000-0002-4280-5670 FU Medical Biological Defense Research Program; Defense Threat Reduction Agency (DTRA) FX This research was funded by the Medical Biological Defense Research Program; Defense Threat Reduction Agency (DTRA). The funders had a role in selecting the bacterial strains which comprised the B. pseudomallei strain panel examined in this work. NR 97 TC 9 Z9 9 U1 3 U2 6 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD APR 24 PY 2015 VL 10 IS 4 AR e0124667 DI 10.1371/journal.pone.0124667 PG 24 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA CG6AH UT WOS:000353376800098 PM 25909629 ER PT J AU De Souza, MS Phanuphak, N Pinyakorn, S Trichavaroj, R Pattanachaiwit, S Chomchey, N Fletcher, JL Kroon, ED Michael, NL Phanuphak, P Kim, JH Ananworanich, J AF De Souza, Mark S. Phanuphak, Nittaya Pinyakorn, Suteeraporn Trichavaroj, Rapee Pattanachaiwit, Supanit Chomchey, Nitiya Fletcher, James L. Kroon, Eugene D. Michael, Nelson L. Phanuphak, Praphan Kim, Jerome H. Ananworanich, Jintanat CA SEARCH 010 Study Grp TI Impact of nucleic acid testing relative to antigen/antibody combination immunoassay on the detection of acute HIV infection SO AIDS LA English DT Article DE acute HIV infection; Bangkok; Fiebig; HIV antigen; antibody combination assay; pooled nucleic acid testing ID AG/AB COMBO ASSAY; P24 ANTIGEN; TRANSMISSION; RNA; POPULATION; SENSITIVITY; PERFORMANCE; STRATEGIES; ALGORITHM; SPECIMENS AB Objective:To assess the addition of HIV nucleic acid testing (NAT) to fourth-generation (4thG) HIV antigen/antibody combination immunoassay in improving detection of acute HIV infection (AHI).Methods:Participants attending a major voluntary counseling and testing site in Thailand were screened for AHI using 4thG HIV antigen/antibody immunoassay and sequential less sensitive HIV antibody immunoassay. Samples nonreactive by 4thG antigen/antibody immunoassay were further screened using pooled NAT to identify additional AHI. HIV infection status was verified following enrollment into an AHI study with follow-up visits and additional diagnostic tests.Results:Among 74334 clients screened for HIV infection, HIV prevalence was 10.9% and the overall incidence of AHI (N=112) was 2.2 per 100 person-years. The inclusion of pooled NAT in the testing algorithm increased the number of acutely infected patients detected, from 81 to 112 (38%), relative to 4thG HIV antigen/antibody immunoassay. Follow-up testing within 5 days of screening marginally improved the 4thG immunoassay detection rate (26%). The median CD4(+) T-cell count at the enrollment visit was 353cells/l and HIV plasma viral load was 598289copies/ml.Conclusion:The incorporation of pooled NAT into the HIV testing algorithm in high-risk populations may be beneficial in the long term. The addition of pooled NAT testing resulted in an increase in screening costs of 22% to identify AHI: from $8.33 per screened patient to $10.16. Risk factors of the testing population should be considered prior to NAT implementation given the additional testing complexity and costs. C1 [De Souza, Mark S.; Phanuphak, Nittaya; Pinyakorn, Suteeraporn; Chomchey, Nitiya; Fletcher, James L.; Kroon, Eugene D.; Phanuphak, Praphan; Ananworanich, Jintanat] SEARCH, Bangkok, Thailand. [De Souza, Mark S.; Phanuphak, Nittaya; Pinyakorn, Suteeraporn; Pattanachaiwit, Supanit; Chomchey, Nitiya; Fletcher, James L.; Kroon, Eugene D.; Phanuphak, Praphan] Thai Red Cross AIDS Res Ctr, Bangkok 10330, Thailand. [De Souza, Mark S.] Cooper Human Syst, Nashua, NH USA. [Pinyakorn, Suteeraporn; Phanuphak, Praphan] HIV NAT, Bangkok, Thailand. [Trichavaroj, Rapee; Kroon, Eugene D.] Armed Forces Res Inst Med Sci, Dept Retrovirol, US Component, Bangkok, Thailand. [Michael, Nelson L.; Kim, Jerome H.; Ananworanich, Jintanat] US Mil HIV Res Program, Bethesda, MD USA. [Michael, Nelson L.; Kim, Jerome H.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Ananworanich, Jintanat] Henry M Jackson Fdn Adv Mil Med, Bethesda, MD USA. RP De Souza, MS (reprint author), Thai Red Cross AIDS Res Ctr, SEARCH, Tower 2,2nd Floor,104 Rajdumri Rd, Bangkok 10330, Thailand. EM markdes@searchthailand.org FU US Military HIV Research Program; Walter Reed Army Institute of Research, Rockville, Maryland [W81XWH-07-2-0067] FX Funding source: The study was funded by the US Military HIV Research Program, Walter Reed Army Institute of Research, Rockville, Maryland, under a cooperative agreement (W81XWH-07-2-0067) between the Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., and the US Department of Defense. NR 39 TC 8 Z9 8 U1 1 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0269-9370 EI 1473-5571 J9 AIDS JI Aids PD APR 24 PY 2015 VL 29 IS 7 BP 793 EP 800 DI 10.1097/QAD.0000000000000616 PG 8 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA CG7FV UT WOS:000353469000005 PM 25985402 ER PT J AU Beske, PH Scheeler, SM Adler, M McNutt, PM AF Beske, Phillip H. Scheeler, Stephen M. Adler, Michael McNutt, Patrick M. TI Accelerated intoxication of GABAergic synapses by botulinum neurotoxin A disinhibits stem cell-derived neuron networks prior to network silencing SO FRONTIERS IN CELLULAR NEUROSCIENCE LA English DT Article DE botulinum neurotoxin; stem cell-derived neurons; SNAP-25; synaptic transmission; glutamatergic synapse; GABAergic synapse; botulism ID IN-VITRO; SEROTYPE-A; SNAP-25; TOXIN; RAT; INHIBITION; NEUROTRANSMISSION; IDENTIFICATION; THERAPEUTICS; ENDOCYTOSIS AB Botulinum neurotoxins (BoNTs) are extremely potent toxins that specifically cleave SNARE proteins in peripheral synapses, preventing neurotransmitter release. Neuronal responses to BoNT intoxication are traditionally studied by quantifying SNARE protein cleavage in vitro or monitoring physiological paralysis in vivo. Consequently, the dynamic effects of intoxication on synaptic behaviors are not well-understood. We have reported that mouse embryonic stem cell-derived neurons (ESNs) are highly sensitive to BoNT based on molecular readouts of intoxication. Here we study the time-dependent changes in synapse- and network-level behaviors following addition of BoNT/A to spontaneously active networks of glutamatergic and GABAergic ESNs. Whole-cell patch-clamp recordings indicated that BoNT/A rapidly blocked synaptic neurotransmission, confirming that ESNs replicate the functional pathophysiology responsible for clinical botulism. Quantitation of spontaneous neurotransmission in pharmacologically isolated synapses revealed accelerated silencing of GABAergic synapses compared to glutamatergic synapses, which was consistent with the selective accumulation of cleaved SNAP-25 at GAD1(+) pre-synaptic terminals at early timepoints. Different latencies of intoxication resulted in complex network responses to BoNT/A addition, involving rapid disinhibition of stochastic firing followed by network silencing. Synaptic activity was found to be highly sensitive to SNAP-25 cleavage, reflecting the functional consequences of the localized cleavage of the small subpopulation of SNAP-25 that is engaged in neurotransmitter release in the nerve terminal. Collectively these findings illustrate that use of synaptic function assays in networked neurons cultures offers a novel and highly sensitive approach for mechanistic studies of toxin:neuron interactions and synaptic responses to BoNT. C1 [Beske, Phillip H.; Scheeler, Stephen M.; Adler, Michael; McNutt, Patrick M.] US Army, Med Res Inst Chem Def, Cellular & Mol Biol Branch, Div Res, Aberdeen Proving Ground, MD 21010 USA. RP McNutt, PM (reprint author), US Army, Med Res Inst Chem Def, 3100 Ricketts Point Rd, Aberdeen Proving Ground, MD 21010 USA. EM patrick.m.mcnutt2.civ@mail.mil OI McNutt, Patrick/0000-0002-5703-4565 FU National Institutes of Health National Institute of Allergy and Infectious Diseases (IAA) [A0D12058-0001-0000]; Defense Threat Reduction Agency-Joint Science and Technology Office, Medical ST Division [CBM.THRTOX.01.10.RC.023, CBM.THRTOX.01.RC.014]; Defense Threat Reduction Agency-National Research Council Research Associateship Award FX This work was funded by the National Institutes of Health National Institute of Allergy and Infectious Diseases (IAA number A0D12058-0001-0000) and the Defense Threat Reduction Agency-Joint Science and Technology Office, Medical S&T Division (grant numbers CBM.THRTOX.01.10.RC.023 and CBM.THRTOX.01.RC.014). This research was performed while PB held a Defense Threat Reduction Agency-National Research Council Research Associateship Award. NR 48 TC 4 Z9 4 U1 0 U2 1 PU FRONTIERS RESEARCH FOUNDATION PI LAUSANNE PA PO BOX 110, LAUSANNE, 1015, SWITZERLAND SN 1662-5102 J9 FRONT CELL NEUROSCI JI Front. Cell. Neurosci. PD APR 23 PY 2015 VL 9 AR 159 DI 10.3389/fncel.2015.00159 PG 12 WC Neurosciences SC Neurosciences & Neurology GA CI5LA UT WOS:000354796400001 PM 25954159 ER PT J AU Read, JA AF Read, Jeffrey A. TI In-Situ Studies on the Electrochemical Intercalation of Hexafluorophosphate Anion in Graphite with Selective Cointercalation of Solvent SO JOURNAL OF PHYSICAL CHEMISTRY C LA English DT Article ID REVERSIBLE INTERCALATION; ELECTROLYTES; CELLS; SPECTROSCOPY; PYROGRAPHITE; FLUORIDES; CARBONATE; OXIDATION; BEHAVIOR; BATTERY AB Electrochemical cells utilizing graphite intercalation compounds at both electrodes have been proposed as an energy storage technology where the electrolyte salt is split and stored in the electrodes on Charge and reformed on discharge. The anion intercalation compounds of graphite proposed as cathodes in these systems have been studied in electrolytes that are resistant to oxidation at 5 V but that are incompatible with graphite anodes, Recent work has demonstrated that electrolytes based Ion monofluoroethylene carbonate (FEC) and ethylmethyl carbonate (EMC) have superior oxidative stability on graphite cathodes over previously studied electrolytes and form a stable, solid electrolyte interphase (SEI), on graphite anodes that allow for full dual-graphite cells to be evaluated for energy storage applications. There is still a limited understanding as to structure of the anion intercalate formed in these electrolyte systems and the effect of solvent cointercalation on cathode performance. This effort was undertaken using a number of in situ techniques to better characterize the fully intercalated composition as well as to investigate the process of solvent cointercalation: It was shown that a series of stages based on the C24PF6 composition are formed until, upon reaching full charge, the structure approaches a C20PF6 stage I composition with PF6- anion in close contact with the graphite layers and 0.7 molecules of cointercalated solvent. For the first time, we have shown that solvent molecules move with anion during the intercalation/deintercalation process while analysis of fully intercalated crystals demonstrated that there is an unusually strong preference for EMC over FEC to cointercalate in this anion intercalation compound. C1 US Army, Res Lab, Adelphi, MD 20783 USA. RP Read, JA (reprint author), US Army, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM jeffrey.a.read4.civ@mail.mil FU Army Research Laboratory FX The author would like to acknowledge Dr. Janet Ho for help with dilatometry, Dr. Jan Allen for helpful discussion on XRD indexing, Dr. Kang Xu, and Dr. Arthur Cresce for electrolytes and the US Army Research Laboratory for financial support. NR 28 TC 9 Z9 9 U1 8 U2 59 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1932-7447 J9 J PHYS CHEM C JI J. Phys. Chem. C PD APR 23 PY 2015 VL 119 IS 16 BP 8438 EP 8446 DI 10.1021/jp5115465 PG 9 WC Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary SC Chemistry; Science & Technology - Other Topics; Materials Science GA CG8ZF UT WOS:000353603500003 ER PT J AU Han, SD Yun, SH Borodin, O Seo, DM Sommer, RD Young, VG Henderson, WA AF Han, Sang-Don Yun, Sun-Hyun Borodin, Oleg Seo, Daniel M. Sommer, Roger D. Young, Victor G., Jr. Henderson, Wesley A. TI Solvate Structures and Computational/Spectroscopic Characterization of LiPF6 Electrolytes SO JOURNAL OF PHYSICAL CHEMISTRY C LA English DT Article ID HIGHLY ASSOCIATED SALTS; RAY CRYSTAL-STRUCTURE; IONIC ASSOCIATION; LITHIUM HEXAFLUOROPHOSPHATE; VIBRATIONAL FREQUENCIES; MIXTURES; COMPLEXES; CHEMISTRY; CATION; CARBONATES AB Raman spectroscopy is a powerful method for identifying ion-ion interactions, but only if the vibrational band signatures for the anion coordination modes can be accurately deciphered. The present study characterizes the PF6- anion P-F Raman symmetric stretching vibrational band for evaluating the PF6-center dot center dot center dot Li+ cation interactions within LiPF6 crystalline solvates to create a characterization tool for liquid electrolytes. To facilitate this, the crystal structures for two new solvates-(G3)(1):LiPF6 and (DEC)(2):LiPF6 with triglyme and diethyl carbonate, respectively-are reported. DFT calculations for Li-PF6 solvates have been used to aid in the assignments. of the spectroscopic signatures. The information,,obtained from this analysis provides key guidance about the ionic,association information which may be obtained from a Raman spectroscopic evaluation of electrolytes containing the LiPF6 salt and aprotic solvents. Of particular note is the overlap of the Raman bands for both solvent-separated ion pair (SSIP) and contact ion pair (CIP) coordination In which the PF6- anions are uncoordinated or coordinated to a single Li+ cation, respectively. C1 [Han, Sang-Don; Yun, Sun-Hyun; Seo, Daniel M.; Henderson, Wesley A.] N Carolina State Univ, Dept Chem & Biomol Engn, Ion Liquids & Elect Energy Technol ILEET Lab, Raleigh, NC 27695 USA. [Yun, Sun-Hyun] GIST, Sch Environm Sci & Engn, Gwangju 500712, South Korea. [Borodin, Oleg] US Army, Electrochem Branch, Res Lab, Adelphi, MD 20783 USA. [Sommer, Roger D.] N Carolina State Univ, Dept Chem, Xray Struct Facil, Raleigh, NC 27695 USA. [Young, Victor G., Jr.] Univ Minnesota, Dept Chem, Xray Crystallog Lab, Minneapolis, MN 55455 USA. [Henderson, Wesley A.] PNNL, Energy & Environm Directorate, Electrochem Mat & Syst Grp, Richland, WA 99352 USA. RP Borodin, O (reprint author), US Army, Electrochem Branch, Res Lab, Adelphi, MD 20783 USA. EM oleg.a.borodin.civ@mail.mil; wesley.henderson@pnnl.gov RI Borodin, Oleg/B-6855-2012 OI Borodin, Oleg/0000-0002-9428-5291 FU U.S. Department of Energy (DOE) Batteries for Advanced Transportation Technologies (BATT) Program [DE-AC02-05-CH11231]; Department of Chemistry of North Carolina State University; State of North Carolina FX The authors wish to express their gratitude to the U.S. Department of Energy (DOE) Batteries for Advanced Transportation Technologies (BATT) Program which fully supported the experimental portion of this research under Award Number DE-AC02-05-CH11231. The authors also wish to thank the Department of Chemistry of North Carolina State University and the State of North Carolina for funding the purchase of the Apex2 diffractometer. NR 41 TC 8 Z9 8 U1 2 U2 32 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1932-7447 J9 J PHYS CHEM C JI J. Phys. Chem. C PD APR 23 PY 2015 VL 119 IS 16 BP 8492 EP 8500 DI 10.1021/acs.jpcc.5b00826 PG 9 WC Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary SC Chemistry; Science & Technology - Other Topics; Materials Science GA CG8ZF UT WOS:000353603500010 ER PT J AU Korotchenko, V Sathunuru, R Gerena, L Caridha, D Li, QG Kreishman-Deitrick, M Smith, PL Lin, AJ AF Korotchenko, Vasiliy Sathunuru, Ramadas Gerena, Lucia Caridha, Diana Li, Qigui Kreishman-Deitrick, Mara Smith, Philip L. Lin, Ai J. TI Antimalarial Activity of 4-Amidinoquinoline and 10-Amidinobenzonaphthyridine Derivatives SO JOURNAL OF MEDICINAL CHEMISTRY LA English DT Article ID QT-INTERVAL PROLONGATION; PLASMODIUM-FALCIPARUM; CHLOROQUINE-RESISTANCE; IN-VITRO; 4-AMINOQUINOLINE ANALOGS; HEMOZOIN FORMATION; BETA-HEMATIN; SIDE-CHAIN; AMODIAQUINE; MALARIA AB Chloroquine (CQ) has been used as first line malaria therapeutic drug for decades. Emergence of CQ drug-resistant Plasmodium falciparum malaria throughout endemic areas of the world has limited its clinical value. Mefloquine (MQ) has been used as an effective malaria prophylactic drug due to its being long-acting and having a high potency against blood stage P. falciparum (Pf). However, serious CNS toxicity of MQ has compromised its clinical value as a prophylaxis drug. Therefore, new and inexpensive antimalarial drugs with no cross-resistance to CQ or CNS toxicity are urgently needed to combat this deadly human disease. In this study, a series of new 4-amidinoquinoline (4-AMQ) and 10-amidinobenzonaphthyridine (10-AMB) derivatives were designed, prepared, and assessed to search for new therapeutic agents to replace CQ and MQ. The new derivatives displayed high activity in vitro and in vivo, with no cross-resistance to CQ, and none were toxic in mice up to 160 mpk X 3. The best compound shows IC50 < 1 ng/mL against D6, W2 and C235 Pf clones, low inhibitory activity in hERG K+ channel blockage testing, negativity in the Ames test, and 5/5 cure @ <15 mpk X 3 in mice infected with Plasmodium berghei. In addition to these desirable pharmacological profiles, compound 13b, one of the most active compounds, is metabolically stable in both human and mouse liver microsomal preparations and has a plasma t(1/2) of 50 h in mice, which made it a good MQ replacement candidate. C1 [Korotchenko, Vasiliy; Sathunuru, Ramadas; Gerena, Lucia; Caridha, Diana; Li, Qigui; Kreishman-Deitrick, Mara; Smith, Philip L.; Lin, Ai J.] Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD 20910 USA. RP Lin, AJ (reprint author), Walter Reed Army Inst Res, Div Expt Therapeut, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM aijeng@aol.com FU Military Infectious Diseases Research Program, U.S. Army Medical Research and Materiel Command, Department of Defense, U.S.A [Q282_12_WR] FX The opinions or assertions contained herein are the private views of the authors, and are not to be construed as official, or as reflecting true views of the U.S. Army or the Department of Defense. This research is supported by Grant No. Q282_12_WR, entitled "Hit to Lead Identification of NCEs", from the Military Infectious Diseases Research Program, U.S. Army Medical Research and Materiel Command, Department of Defense, U.S.A. The authors are grateful to CPT Sean Marcsisin, ThuLan Luong, Raul Olmeda, and Delaney Hettithantrige for assistance in metabolic stability studies of the new compounds. NR 72 TC 4 Z9 4 U1 3 U2 14 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0022-2623 EI 1520-4804 J9 J MED CHEM JI J. Med. Chem. PD APR 23 PY 2015 VL 58 IS 8 BP 3411 EP 3431 DI 10.1021/jm501809x PG 21 WC Chemistry, Medicinal SC Pharmacology & Pharmacy GA CG8YS UT WOS:000353602200010 PM 25654185 ER PT J AU Strack, OE Leavy, RB Brannon, RM AF Strack, O. E. Leavy, R. B. Brannon, R. M. TI Aleatory uncertainty and scale effects in computational damage models for failure and fragmentation SO INTERNATIONAL JOURNAL FOR NUMERICAL METHODS IN ENGINEERING LA English DT Article DE constitutive equations; damage; fracture and fragmentation; fuzzy probabilistic methods; impact; rate dependence; scale/size effects; mesh dependence; verification; validation ID DYNAMIC FRAGMENTATION; BRITTLE MATERIALS; SILICON-CARBIDE; BORON-CARBIDE; STRAIN RATES; MECHANICS; FRACTURE; STRENGTH; ELEMENT; IMPACT AB Stress concentrations near grain boundaries, precipitates, and similar micro-heterogeneities nucleate instabilities leading to macroscale fracture. As it is not practical to model each flaw explicitly, their ensemble effect is modeled statistically. Accounting for this aleatory uncertainty requires smaller specimens (e.g., small finite elements) to have generally higher and more variable strengths, which is necessary for the initial failure probability of a finite domain to be unaffected by its discretization into elements. Localization itself, which might be attributed to constitutive instability, requires realistic numerical perturbations to predict bifurcations such as radial cracking in axisymmetric problems. These perturbations, stemming from microscale heterogeneity, are incorporated in simulations by imposing statistical spatial variability in the parameters of an otherwise conventional (deterministic and scale - independent) damage model. This approach is attractive for its algorithmic simplicity and straightforward calibration from standard strength tests. In addition, it results in virtually no loss of efficiency or robustness relative to deterministic models and accommodates general three - dimensional loading. Despite these advantages, some significant challenges remain and are discussed. However, it is demonstrated that including aleatory uncertainty with associated scale effects significantly improves predictiveness on large - scale computational domains, where it is impractical to resolve each crack or localization zone. Copyright (C) 2014 John Wiley & Sons, Ltd. C1 [Strack, O. E.] Sandia Natl Labs, Computat Shock & Multiphys, Albuquerque, NM 87185 USA. [Leavy, R. B.] Army Res Lab, Impact Phys, Aberdeen Proving Ground, MD USA. [Brannon, R. M.] Univ Utah, Mech Engn, Salt Lake City, UT 84105 USA. RP Brannon, RM (reprint author), Univ Utah, Mech Engn, Salt Lake City, UT 84105 USA. EM Rebecca.Brannon@utah.edu FU US Department of Energy's National Nuclear Security Administration [DE-AC04-94AL85000, SAND2014-0865J] FX In addition to administrative, technical, and financial support by Sandia laboratory managers (especially Tom Pfeifle and Randy Summers) and Army Research Laboratory managers (especially Bill Bruchey, Scott Schoenfeld, and Todd Bjerke), funding and support for this work provided by TACOM Project Manager John Rowe is deeply appreciated. We are additionally grateful to the following individuals: Rich Becker (for his 2002 unpublished study of the effect of strength perturbations in plane stress), Tracy Vogler and Lalit Chhabildas (for providing data and constructive feedback), Richard Jensen and Josh Houskamp (for exercising the model in Brazilian simulations and beta-testing), Moo Lee and David Bronowski (for Brazilian and Triaxial testing of SiC-N ceramics), Mike Veilleux (for Monte Carlo verification testing of the Weibull perturbations), and Tim Fuller, Mike Wong, and Greg Sharp (for extensive testing and improvement of the Kayenta model and its implementation in several host codes). The majority of this research was performed at Sandia National Laboratories and the Army Research Laboratory, with some additional support from Schlumberger corporation. Sandia National Laboratories is a multi-program laboratory managed and operated by Sandia Corporation, a wholly owned subsidiary of Lockheed Martin Corporation, for the US Department of Energy's National Nuclear Security Administration under contract DE-AC04-94AL85000. SAND2014-0865J. NR 89 TC 2 Z9 2 U1 2 U2 13 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0029-5981 EI 1097-0207 J9 INT J NUMER METH ENG JI Int. J. Numer. Methods Eng. PD APR 20 PY 2015 VL 102 IS 3-4 SI SI BP 468 EP 495 DI 10.1002/nme.4699 PG 28 WC Engineering, Multidisciplinary; Mathematics, Interdisciplinary Applications SC Engineering; Mathematics GA CF6BZ UT WOS:000352642900014 ER PT J AU Kibuuka, H Berkowitz, NM Millard, M Enama, ME Tindikahwa, A Sekiziyivu, AB Costner, P Sitar, S Glover, D Hu, ZH Joshi, G Stanley, D Kunchai, M Eller, LA Bailer, RT Koup, RA Nabel, GJ Mascola, JR Sullivan, NJ Graham, BS Roederer, M Michael, NL Robb, ML Ledgerwood, JE AF Kibuuka, Hannah Berkowitz, Nina M. Millard, Monica Enama, Mary E. Tindikahwa, Allan Sekiziyivu, Arthur B. Costner, Pamela Sitar, Sandra Glover, Deline Hu, Zonghui Joshi, Gyan Stanley, Daphne Kunchai, Meghan Eller, Leigh Anne Bailer, Robert T. Koup, Richard A. Nabel, Gary J. Mascola, John R. Sullivan, Nancy J. Graham, Barney S. Roederer, Mario Michael, Nelson L. Robb, Merlin L. Ledgerwood, Julie E. CA RV 247 Study Team TI Safety and immunogenicity of Ebola virus and Marburg virus glycoprotein DNA vaccines assessed separately and concomitantly in healthy Ugandan adults: a phase 1b, randomised, double-blind, placebo-controlled clinical trial SO LANCET LA English DT Article ID NONHUMAN-PRIMATES; NEUTROPENIA; VACCINATION; INFECTION; FEVER AB Background Ebola virus and Marburg virus cause serious disease outbreaks with high case fatality rates. We aimed to assess the safety and immunogenicity of two investigational DNA vaccines, one (EBO vaccine) encoding Ebola virus Zaire and Sudan glycoproteins and one (MAR) encoding Marburg virus glycoprotein. Methods RV 247 was a phase 1b, double-blinded, randomised, placebo-controlled clinical trial in Kampala, Uganda to examine the safety and immunogenicity of the EBO and MAR vaccines given individually and concomitantly. Healthy adult volunteers aged 18-50 years were randomly assigned (5: 1) to receive three injections of vaccine or placebo at weeks 0, 4, and 8, with vaccine allocations divided equally between three active vaccine groups: EBO vaccine only, MAR vaccine only, and both vaccines. The primary study objective was to investigate the safety and tolerability of the vaccines, as assessed by local and systemic reactogenicity and adverse events. We also assessed immunogenicity on the basis of antibody responses (ELISA) and T-cell responses (ELISpot and intracellular cytokine staining assays) 4 weeks after the third injection. Participants and investigators were masked to group assignment. Analysis was based on the intention-to-treat principle. This trial is registered at ClinicalTrials.gov, number NCT00997607. Findings 108 participants were enrolled into the study between Nov 2, 2009, and April 15, 2010. All 108 participants received at least one study injection (including 100 who completed the injection schedule) and were included in safety and tolerability analyses; 107 for whom data were available were included in the immunogenicity analyses. Study injections were well tolerated, with no significant differences in local or systemic reactions between groups. The vaccines elicited antibody and T-cell responses specific to the glycoproteins received and we detected no differences between the separate and concomitant use of the two vaccines. 17 of 30 (57%, 95% CI 37-75) participants in the EBO vaccine group had an antibody response to the Ebola Zaire glycoprotein, as did 14 of 30 (47%, 28-66) in the group that received both vaccines. 15 of 30 (50%, 31-69) participants in the EBO vaccine group had an antibody response to the Ebola Sudan glycoprotein, as did 15 of 30 (50%, 31-69) in the group that received both vaccines. Nine of 29 (31%, 15-51) participants in the MAR vaccine groups had an antibody response to the Marburg glycoprotein, as did seven of 30 (23%, 10-42) in the group that received both vaccines. 19 of 30 (63%, 44-80) participants in the EBO vaccine group had a T-cell response to the Ebola Zaire glycoprotein, as did 10 of 30 (33%, 17-53) in the group that received both vaccines. 13 of 30 (43%, 25-63) participants in the EBO vaccine group had a T-cell response to the Ebola Sudan glycoprotein, as did 10 of 30 (33%, 17-53) in the group that received both vaccines. 15 of 29 (52%, 33-71) participants in the MAR vaccine group had a T-cell response to the Marburg glycoprotein, as did 13 of 30 (43%, 25-63) in the group that received both vaccines. Interpretation This study is the first Ebola or Marburg vaccine trial done in Africa, and the results show that, given separately or together, both vaccines were well tolerated and elicited antigen-specific humoral and cellular immune responses. These findings have contributed to the accelerated development of more potent Ebola virus vaccines that encode the same wild-type glycoprotein antigens as the EBO vaccine, which are being assessed during the 2014 Ebola virus disease outbreak in west Africa. C1 [Kibuuka, Hannah; Millard, Monica; Tindikahwa, Allan; Sekiziyivu, Arthur B.] Makerere Univ, Walter Reed Project, Kampala, Uganda. [Berkowitz, Nina M.; Enama, Mary E.; Costner, Pamela; Sitar, Sandra; Stanley, Daphne; Bailer, Robert T.; Koup, Richard A.; Nabel, Gary J.; Mascola, John R.; Sullivan, Nancy J.; Graham, Barney S.; Roederer, Mario; Ledgerwood, Julie E.] NIAID, Vaccine Res Ctr, NIH, Bethesda, MD 20892 USA. [Hu, Zonghui] NIAID, Biostat Res Branch, Div Clin Res, NIH, Bethesda, MD 20892 USA. [Glover, Deline; Eller, Leigh Anne; Michael, Nelson L.; Robb, Merlin L.] US Mil HIV Res Program, Bethesda, MD USA. [Joshi, Gyan] Frederick Natl Lab Canc Res, Clin Monitoring Res Program, Leidos Biomed Res, Frederick, MD USA. [Kunchai, Meghan] EMMES Corp, Rockville, MD USA. [Nabel, Gary J.] Sanofi, Cambridge, MA USA. [Michael, Nelson L.] Walter Reed Army Inst Res, Silver Spring, MD USA. RP Ledgerwood, JE (reprint author), NIAID, Vaccine Res Ctr, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA. EM Ledgerwood@mail.nih.gov FU US Department of Defense Infectious Disease Clinical Research Program; US National Institutes of Health Intramural Research Program FX US Department of Defense Infectious Disease Clinical Research Program and US National Institutes of Health Intramural Research Program. NR 33 TC 22 Z9 24 U1 2 U2 25 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0140-6736 EI 1474-547X J9 LANCET JI Lancet PD APR 18 PY 2015 VL 385 IS 9977 BP 1545 EP 1554 DI 10.1016/S0140-6736(14)62385-0 PG 10 WC Medicine, General & Internal SC General & Internal Medicine GA CG3ZT UT WOS:000353220000036 PM 25540891 ER PT J AU West, BJ Turalska, M Grigolini, P AF West, B. J. Turalska, M. Grigolini, Paolo TI Fractional calculus ties the microscopic and macroscopic scales of complex network dynamics SO NEW JOURNAL OF PHYSICS LA English DT Article DE complex networks; fractional calculus; decision making ID TRANSITIONS; STATISTICS AB A two-state, master equation-based decision-making model has been shown to generate phase transitions, to be topologically complex, and to manifest temporal complexity through an inverse power-law probability distribution function in the switching times between the two critical states of consensus. These properties are entailed by the fundamental assumption that the network elements in the decision-making model imperfectly imitate one another. The process of subordination establishes that a single network element can be described by a fractional master equation whose analytic solution yields the observed inverse power-law probability distribution obtained by numerical integration of the two-state master equation to a high degree of accuracy. C1 [West, B. J.; Turalska, M.] Duke Univ, Dept Phys, Durham, NC 27709 USA. [West, B. J.] US Army, Res Off, Informat Sci Directorate, Res Triangle Pk, NC 27708 USA. [Grigolini, Paolo] Univ N Texas, Ctr Nonlinear Sci, Denton, TX 76203 USA. RP West, BJ (reprint author), Duke Univ, Dept Phys, Durham, NC 27709 USA. EM bruce.j.west.civ@mail.mil; mat51@phy.duke.edu; grigo@unt.edu FU US Army Research Office; ARO [W911NF-11-1-0478, W911NF-04-D-0001]; Welch Foundation [B-1577] FX The authors would like to thank the US Army Research Office for supporting this research. P.G. warmly thanks the ARO and the Welch Foundation for their support through Grants No. W911NF-11-1-0478 and No. B-1577, respectively. MT thanks the ARO for their support through Grant No. W911NF-04-D-0001. NR 35 TC 4 Z9 4 U1 1 U2 9 PU IOP PUBLISHING LTD PI BRISTOL PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND SN 1367-2630 J9 NEW J PHYS JI New J. Phys. PD APR 17 PY 2015 VL 17 AR 045009 DI 10.1088/1367-2630/17/4/045009 PG 13 WC Physics, Multidisciplinary SC Physics GA CH4SL UT WOS:000354023100001 ER PT J AU Kaplan, JE Hamm, TE Forhan, S Hassani, AS Bang, G Weyant, E Tchuenche, M Langley, C Lapidos-Salaiz, I Bateganya, MH AF Kaplan, Jonathan E. Hamm, Tiffany E. Forhan, Sara Hassani, Ahmed Saadani Bang, Gail Weyant, Emily Tchuenche, Michel Langley, Carol Lapidos-Salaiz, Ilana Bateganya, Moses H. TI The Impact of HIV Care and Support Interventions on Key Outcomes in Low- and Middle-Income Countries: A Literature Review-Introduction SO JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES LA English DT Article C1 [Kaplan, Jonathan E.; Forhan, Sara; Hassani, Ahmed Saadani; Tchuenche, Michel; Bateganya, Moses H.] Ctr Dis Control & Prevent, Div Global HIV AIDS, Ctr Global Hlth, Atlanta, GA 30333 USA. [Hamm, Tiffany E.] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD USA. [Hamm, Tiffany E.] Henry M Jackson Fdn Adv Mil Med, Bethesda, MD USA. [Bang, Gail; Weyant, Emily] CDC, Div Epidemiol Anal & Lib Serv, Ctr Surveillance Epidemiol & Lab Serv, Atlanta, GA 30333 USA. [Langley, Carol] US Dept State, Off US Global AIDS Coordinator & Hlth Diplomacy, Washington, DC 20520 USA. [Lapidos-Salaiz, Ilana] US Agcy Int Dev, Washington, DC 20523 USA. RP Kaplan, JE (reprint author), Ctr Dis Control & Prevent, Div Global HIV AIDS, Mailstop E-04,1600 Clifton Rd NE, Atlanta, GA 30333 USA. EM jxk2@cdc.gov FU US President's Emergency Plan for AIDS Relief (PEPFAR) through the US Department of State, Office of the US Global AIDS Coordinator and Health Diplomacy; US Centers for Disease Control and Prevention; US Agency for International Development; Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. [W81XWH-07-2-0067]; US Department of Defense [W81XWH-07-2-0067] FX Supported by the US President's Emergency Plan for AIDS Relief (PEPFAR) through the US Department of State, Office of the US Global AIDS Coordinator and Health Diplomacy, the US Centers for Disease Control and Prevention, and the US Agency for International Development, and also supported through a cooperative agreement (W81XWH-07-2-0067) between The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. and the US Department of Defense. NR 7 TC 13 Z9 13 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1525-4135 EI 1077-9450 J9 JAIDS-J ACQ IMM DEF JI JAIDS PD APR 15 PY 2015 VL 68 SU 3 BP S253 EP S256 DI 10.1097/QAI.0000000000000495 PG 4 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA CH6CN UT WOS:000354123500001 PM 25768864 ER PT J AU Langley, CL Lapidos-Salaiz, I Hamm, TE Bateganya, MH Firth, J Wilson, M Martin, J Dierberg, K AF Langley, Carol L. Lapidos-Salaiz, Ilana Hamm, Tiffany E. Bateganya, Moses H. Firth, Jacqueline Wilson, Melinda Martin, Julia Dierberg, Kerry TI Prioritizing HIV Care and Support Interventions-Moving From Evidence to Policy SO JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES LA English DT Article DE HIV; care; support; policy; LMIC C1 [Langley, Carol L.; Martin, Julia; Dierberg, Kerry] US Dept State, Off US Global AIDS Coordinator & Hlth Diplomacy S, Washington, DC 20522 USA. [Lapidos-Salaiz, Ilana; Firth, Jacqueline; Wilson, Melinda] US Agcy Int Dev, Off HIV AIDS, Washington, DC 20523 USA. [Hamm, Tiffany E.] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD USA. [Hamm, Tiffany E.] Henry M Jackson Fdn Adv Mil Med, Bethesda, MD USA. [Bateganya, Moses H.] Ctr Dis Control & Prevent CDC, Div Global HIV AIDS, Ctr Global Hlth, Atlanta, GA USA. RP Langley, CL (reprint author), US Dept State, Off US Global AIDS Coordinator & Hlth Diplomacy S, SA-22,Room 10300, Washington, DC 20522 USA. EM langleycl@state.gov FU US President's Emergency Plan for AIDS Relief (PEPFAR) through the United States Department of State, Office of the US Global AIDS Coordinator and Health Diplomacy; US Centers for Disease Control; US Agency for International Development; Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. [W81XWH-07-2-0067]; US Department of Defense [W81XWH-07-2-0067] FX Supported by the US President's Emergency Plan for AIDS Relief (PEPFAR) through the United States Department of State, Office of the US Global AIDS Coordinator and Health Diplomacy, the US Centers for Disease Control, and the US Agency for International Development as well as supported through a cooperative agreement (W81XWH-07-2-0067) between The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. and the US Department of Defense. NR 5 TC 1 Z9 1 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1525-4135 EI 1077-9450 J9 JAIDS-J ACQ IMM DEF JI JAIDS PD APR 15 PY 2015 VL 68 SU 3 BP S375 EP S378 DI 10.1097/QAI.0000000000000545 PG 4 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA CH6CN UT WOS:000354123500014 PM 25768877 ER PT J AU Stabinski, L O'Connor, S Barnhart, M Kahn, RJ Hamm, TE AF Stabinski, Lara O'Connor, Siobhan Barnhart, Matthew Kahn, Rebecca J. Hamm, Tiffany E. TI Prevalence of HIV and Hepatitis B Virus Co-Infection in Sub-Saharan Africa and the Potential Impact and Program Feasibility of Hepatitis B Surface Antigen Screening in Resource-Limited Settings SO JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES LA English DT Article DE hepatitis B virus; resource-limited setting; hepatitis B surface antigen; rapid strip assay; HIV; HBV co-infection ID HUMAN-IMMUNODEFICIENCY-VIRUS; RECEIVING ANTIRETROVIRAL THERAPY; CAMILLE MEDICAL-CENTER; C VIRAL COINFECTIONS; DAR-ES-SALAAM; INFECTED PATIENTS; SOUTH-AFRICA; PREGNANT-WOMEN; BURKINA-FASO; POSITIVE PATIENTS AB Background:Screening people living with HIV for hepatitis B virus (HBV) co-infection is recommended in resource-rich settings to optimize HIV antiretroviral therapy (ART) and mitigate HBV-related liver disease. This review examines the need, feasibility, and impact of screening for HBV in resource-limited settings (RLS).Methods:We searched 6 databases to identify peer-reviewed publications between 2007 and 2013 addressing (1) HIV/HBV co-infection frequency in sub-Saharan Africa (SSA); (2) performance of hepatitis B surface antigen (HBsAg) rapid strip assays (RSAs) in RLS; (3) impact of HBV co-infection on morbidity, mortality, or liver disease progression; and/or (4) impact of HBV-suppressive antiretroviral medications as part of ART on at least one of 5 outcomes (mortality, morbidity, HIV transmission, retention in HIV care, or quality of life). We rated the quality of individual articles and summarized the body of evidence and expected impact of each intervention per outcome addressed.Results:Of 3940 identified studies, 85 were included in the review: 55 addressed HIV/HBV co-infection frequency; 6 described HBsAg RSA performance; and 24 addressed the impact of HIV/HBV co-infection and ART. HIV/HBV frequency in sub-Saharan Africa varied from 0% to >28.4%. RSA performance in RLS showed good, although variable, sensitivity and specificity. Quality of studies ranged from strong to weak. Overall quality of evidence for the impact of HIV/HBV co-infection and ART on morbidity and mortality was fair and good to fair, respectively.Conclusions:Combined, the body of evidence reviewed suggests that HBsAg screening among people living with HIV could have substantial impact on preventing morbidity and mortality among HIV/HBV co-infected individuals in RLS. C1 [Stabinski, Lara; Kahn, Rebecca J.] US Dept State, Off US Global AIDS Coordinator & Hlth Diplomacy, Washington, DC 20006 USA. [O'Connor, Siobhan] US Ctr Dis Control & Prevent, Div Viral Hepatitis, Natl Ctr HIV AIDS STD & TB Prevent, Atlanta, GA USA. [Barnhart, Matthew] US Agcy Int Dev, Off HIV & AIDS, Bur Global Hlth, Washington, DC 20523 USA. [Hamm, Tiffany E.] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD USA. [Hamm, Tiffany E.] Henry M Jackson Fdn Adv Mil Med Inc, Bethesda, MD USA. RP Stabinski, L (reprint author), US Dept State, Off US Global AIDS Coordinator & Hlth Diplomacy, 1800 G St NW,SA-22, Washington, DC 20006 USA. EM stabinskill@state.gov FU US President's Emergency Plan for AIDS Relief (PEPFAR) through the United States Department of State, Office of the US Global AIDS Coordinator and Health Diplomacy; US Agency for International Development; US Centers for Disease Control and Prevention; Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. [W81XWH-07-2-0067]; US Department of Defense [W81XWH-07-2-0067] FX Supported by the US President's Emergency Plan for AIDS Relief (PEPFAR) through the United States Department of State, Office of the US Global AIDS Coordinator and Health Diplomacy, the US Agency for International Development, the US Centers for Disease Control and Prevention, as well as supported through a cooperative agreement (W81XWH-07-2-0067) between the Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. and the US Department of Defense. NR 98 TC 5 Z9 5 U1 0 U2 6 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1525-4135 EI 1077-9450 J9 JAIDS-J ACQ IMM DEF JI JAIDS PD APR 15 PY 2015 VL 68 SU 3 BP S274 EP S285 DI 10.1097/QAI.0000000000000496 PG 12 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA CH6CN UT WOS:000354123500004 PM 25768867 ER PT J AU Miller, SL Aroniadou-Anderjaska, V Figueiredo, TH Prager, EM Almeida-Suhett, CP Apland, JP Braga, MFM AF Miller, Steven L. Aroniadou-Anderjaska, Vassiliki Figueiredo, Taiza H. Prager, Eric M. Almeida-Suhett, Camila P. Apland, James P. Braga, Maria F. M. TI A rat model of nerve agent exposure applicable to the pediatric population: The anticonvulsant efficacies of atropine and GluK1 antagonists SO TOXICOLOGY AND APPLIED PHARMACOLOGY LA English DT Article DE Immature rats; Soman; Seizures; Acetylcholinesterase; Atropine sulfate; GluK1 antagonists ID KAINATE RECEPTOR ANTAGONIST; TEMPORAL-LOBE EPILEPSY; BASOLATERAL AMYGDALA; INDUCED SEIZURES; STATUS EPILEPTICUS; DEVELOPING BRAIN; IMMATURE BRAIN; ACETYLCHOLINESTERASE ACTIVITY; DEVELOPMENTAL-CHANGES; SOMAN-EXPOSURE AB Inhibition of acetylcholinesterase (AChE) after nerve agent exposure induces status epilepticus (SE), which causes brain damage or death. The development of countermeasures appropriate for the pediatric population requires testing of anticonvulsant treatments in immature animals. In the present study, exposure of 21-day-old (P21) rats to different doses of soman, followed by probit analysis, produced an LD50 of 62 mu g/kg. The onset of behaviorally-observed SE was accompanied by a dramatic decrease in brain AChE activity; rats who did not develop SE had significantly less reduction of AChE activity in the basolateral amygdala than rats who developed SE. Atropine sulfate (ATS) at 2 mg/kg, administered 20 min after soman exposure (1.2 x LD50), terminated seizures. ATS at 0.5 mg/kg, given along with an oxime within 1 min after exposure, allowed testing of anticonvulsants at delayed time-points. The AMPA/GluK1 receptor antagonist LY293558, or the specific GluK1 antagonist UBP302, administered 1 h post-exposure, terminated SE. There were no degenerating neurons in soman-exposed P21 rats, but both the amygdala and the hippocampus were smaller than in control rats at 30 and 90 days post-exposure; this pathology was not present in rats treated with LY293558. Behavioral deficits present at 30 days post-exposure, were also prevented by LY293558 treatment. Thus, in immature animals, a single injection of atropine is sufficient to halt nerve agent-induced seizures, if administered timely. Testing anticonvulsants at delayed time-points requires early administration of ATS at a low dose, sufficient to counteract only peripheral toxicity. LY293558 administered 1 h post-exposure, prevents brain pathology and behavioral deficits. Published by Elsevier Inc. C1 [Miller, Steven L.; Aroniadou-Anderjaska, Vassiliki; Figueiredo, Taiza H.; Prager, Eric M.; Almeida-Suhett, Camila P.; Braga, Maria F. M.] Uniformed Serv Univ Hlth Sci, Dept Anat Physiol & Genet, Bethesda, MD 20814 USA. [Aroniadou-Anderjaska, Vassiliki; Braga, Maria F. M.] Uniformed Serv Univ Hlth Sci, Dept Psychiat, Bethesda, MD 20814 USA. [Miller, Steven L.; Aroniadou-Anderjaska, Vassiliki; Prager, Eric M.; Almeida-Suhett, Camila P.; Braga, Maria F. M.] Uniformed Serv Univ Hlth Sci, Program Neurosci, Bethesda, MD 20814 USA. [Apland, James P.] US Army, Med Res Inst Chem Def, Neurotoxicol Branch, Aberdeen Proving Ground, MD 21010 USA. RP Braga, MFM (reprint author), Uniformed Serv Univ Hlth Sci, F Edward Hebert Sch Med, Dept Anat Physiol & Genet, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA. EM stevenmiller17@gmail.com; vanderjaska@usuhs.edu; taiza.figueiredo.ctr@usuhs.edu; eric.prager683@gmail.com; camilapalmeida@gmail.com; james.p.apland.civ@mail.mil; maria.braga@usuhs.edu RI Prager, Eric/O-1567-2015; OI Prager, Eric/0000-0002-3810-0985; Miller, Steven/0000-0002-2061-8188 FU CounterACT Program, National Institutes of Health, Office of the Director; National Institute of Neurologic Disorders and Stroke [5U01NS058162-07] FX We thank Dr. Cara H. Olsen for her expert advice on the procedure for the estimation of LD50. This work was supported by the CounterACT Program, National Institutes of Health, Office of the Director and the National Institute of Neurologic Disorders and Stroke [Grant Number 5U01NS058162-07]. NR 91 TC 4 Z9 4 U1 0 U2 16 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0041-008X EI 1096-0333 J9 TOXICOL APPL PHARM JI Toxicol. Appl. Pharmacol. PD APR 15 PY 2015 VL 284 IS 2 BP 204 EP 216 DI 10.1016/j.taap.2015.02.008 PG 13 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA CH2OH UT WOS:000353864000011 PM 25689173 ER PT J AU Akers, KS Rowan, MP Niece, KL Graybill, JC Mende, K Chung, KK Murray, CK AF Akers, Kevin S. Rowan, Matthew P. Niece, Krista L. Graybill, John C. Mende, Katrin Chung, Kevin K. Murray, Clinton K. TI Antifungal wound penetration of amphotericin and voriconazole in combat-related injuries: case report SO BMC INFECTIOUS DISEASES LA English DT Article DE Invasive fungal infection; Pharmacokinetics; Negative-Pressure Wound Therapy; NPWT; Effluent ID INVASIVE FUNGAL-INFECTIONS; B DEOXYCHOLATE; EXPRESSION; PLASMA; PHARMACOKINETICS; EPIDEMIOLOGY; BATTLEFIELD; BIOMARKERS; CYTOKINE; REGIMENS AB Background: Survivors of combat trauma can have long and challenging recoveries, which may be complicated by infection. Invasive fungal infections are a rare but serious complication with limited treatment options. Currently, aggressive surgical debridement is the standard of care, with antifungal agents used adjunctively with uncertain efficacy. Anecdotal evidence suggests that antifungal agents may be ineffective in the absence of surgical debridement, and studies have yet to correlate antifungal concentrations in plasma and wounds. Case presentation: Here we report the systemic pharmacokinetics and wound effluent antifungal concentrations of five wounds from two male patients, aged 28 and 30 years old who sustained combat-related blast injuries in southern Afghanistan, with proven or possible invasive fungal infection. Our data demonstrate that while voriconazole sufficiently penetrated the wound resulting in detectable effluent levels, free amphotericin B (unbound to plasma) was not present in wound effluent despite sufficient concentrations in circulating plasma. In addition, considerable between-patient and within-patient variability was observed in antifungal pharmacokinetic parameters. Conclusion: These data highlight the need for further studies evaluating wound penetration of commonly used antifungals and the role for therapeutic drug monitoring in providing optimal care for critically ill and injured war fighters. C1 [Akers, Kevin S.; Rowan, Matthew P.; Niece, Krista L.; Graybill, John C.; Chung, Kevin K.] US Army, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Akers, Kevin S.; Mende, Katrin; Murray, Clinton K.] San Antonio Mil Med Ctr, Dept Med, Infect Dis Serv, Ft Sam Houston, TX 78234 USA. [Mende, Katrin] Uniformed Serv Univ Hlth Sci, Infect Dis Clin Res Program, Bethesda, MD 20814 USA. [Chung, Kevin K.; Murray, Clinton K.] Uniformed Serv Univ Hlth Sci, Dept Med, Bethesda, MD 20814 USA. RP Akers, KS (reprint author), US Army, Inst Surg Res, 3698 Chambers Pass,JBSA, Ft Sam Houston, TX 78234 USA. EM kevin.s.akers.mil@mail.mil FU Defense Medical Research & Development Program (DMRDP) Military Infectious Disease Clinical Trial Award (MID-CTA) [D_MIDCTA_I_12_J2_299]; U.S. Department of Energy; USAMRMC FX This study was conducted under a protocol reviewed and approved by the U.S. Army Medical Research and Materiel Command Institutional Review Board and in accordance with approved protocols BAMC C.2013.095 and H-09-059. This work was supported by Defense Medical Research & Development Program (DMRDP) Military Infectious Disease Clinical Trial Award (MID-CTA) #D_MIDCTA_I_12_J2_299, and in part by an appointment to the Postgraduate Research Participation Program at the U.S. Army Institute of Surgical Research administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the U.S. Department of Energy and USAMRMC. A portion of this material was presented at the 2014 Military Health Systems Research Symposium, Ft. Lauderdale FL. We gratefully acknowledge the invaluable contributions of Doug Johnson LVN, Kristie Harnisch RN, Crystal Rosemann RN, Charnae Williams BS, and the participating research subjects, without whom this research would not be possible. NR 32 TC 2 Z9 2 U1 1 U2 2 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1471-2334 J9 BMC INFECT DIS JI BMC Infect. Dis. PD APR 15 PY 2015 VL 15 AR 184 DI 10.1186/s12879-015-0918-8 PG 7 WC Infectious Diseases SC Infectious Diseases GA CG3PN UT WOS:000353192200001 PM 25886578 ER PT J AU Tachibana, M Suwanabun, N Kaneko, O Iriko, H Otsuki, H Sattabongkot, J Kaneko, A Herrera, S Torii, M Tsuboi, T AF Tachibana, Mayumi Suwanabun, Nantavadee Kaneko, Osamu Iriko, Hideyuki Otsuki, Hitoshi Sattabongkot, Jetsumon Kaneko, Akira Herrera, Socrates Torii, Motomi Tsuboi, Takafumi TI Plasmodium vivax gametocyte proteins, Pvs48/45 and Pvs47, induce transmission-reducing antibodies by DNA immunization SO VACCINE LA English DT Article DE DNA vaccine; Gametocyte; Malaria; Plasmodium vivax; Polymorphism; Transmission-blocking vaccine ID BLOCKING VACCINE CANDIDATES; SURFACE PROTEIN; SEQUENCE POLYMORPHISMS; TARGET ANTIGENS; HUMAN MALARIA; SEXUAL STAGE; FALCIPARUM; PFS48/45; PVS25; IMMUNITY AB Malaria transmission-blocking vaccines (TBV) aim to interfere with the development of the malaria parasite in the mosquito vector, and thus prevent spread of transmission in a community. To date three TBV candidates have been identified in Plasmodium vivax; namely, the gametocyte/gamete protein Pvs230, and the ookinete surface proteins Pvs25 and Pvs28. The Plasmodium falciparum gametocyte/gamete stage proteins Pfs48/45 and Pfs47 have been studied as TBV candidates, and Pfs48/45 shown to induce transmission-blocking antibodies, but the candidacy of their orthologs in P. vivax, Pvs48/45 (PVX_083235) and Pvs47 (PVX_083240), for vivax TBV have not been tested. Herein we investigated whether targeting Pvs48/45 and Pvs47 can inhibit parasite transmission to mosquitoes, using P. vivax isolates obtained in Thailand. Mouse antisera directed against the products from plasmids expressing Pvs48/45 and Pvs47 detected proteins of approximately 45- and 40-kDa, respectively, in the P. vivax gametocyte lysate, by Western blot analysis under non-reducing conditions. In immunofluorescence assays Pvs48/45 was detected predominantly on the surface and Pvs47 was detected in the cytoplasm of gametocytes. Membrane feeding transmission assays demonstrated that anti-Pvs48/45 and -Pvs47 mouse sera significantly reduced the number of P. vivax oocysts developing in the mosquito midgut. Limited amino acid polymorphism of these proteins was observed among 27 P. vivax isolates obtained from Thailand, Vanuatu, and Colombia; suggesting that polymorphism may not be an impediment for the utilization of Pvs48/45 and Pvs47 as TBV antigens. In one Thai isolate we found that the fourth cysteine residue in the Pvs47 cysteine-rich domain (CRD) III (amino acid position 337) is substituted to phenylalanine. However, antibodies targeting Pvs47 CRDI-Ill showed a significant transmission-reducing activity against this isolate, suggesting that this substitution in Pvs47 was not critical for recognition by the generated antibodies. In conclusion, our results indicate that Pvs48/45 and Pvs47 are potential transmission-blocking vaccine candidates of P. vivax. (C) 2015 Elsevier Ltd. All rights reserved. C1 [Tachibana, Mayumi; Torii, Motomi] Ehime Univ, Proteosci Ctr, Div Mol Parasitol, Toon, Ehime 7910295, Japan. [Suwanabun, Nantavadee; Sattabongkot, Jetsumon] Armed Forces Res Inst Med Sci, Dept Entomol, Bangkok 10400, Thailand. [Kaneko, Osamu] Nagasaki Univ, Inst Trop Med NEKKEN, Dept Protozool, Nagasaki 8528523, Japan. [Iriko, Hideyuki] Kobe Univ, Grad Sch Hlth Sci, Fac Hlth Sci, Dept Parasitol, Kobe, Hyogo 6540142, Japan. [Otsuki, Hitoshi] Tottori Univ, Div Med Zool, Fac Med, Yonago, Tottori 6838503, Japan. [Kaneko, Akira] Osaka City Univ, Grad Sch Med, Dept Parasitol, Osaka 5458585, Japan. [Kaneko, Akira] Karolinska Inst, Dept Microbiol Tumor & Cell Biol, Isl Malaria Grp, SE-17777 Stockholm, Sweden. [Herrera, Socrates] Malaria Vaccine & Drug Dev Ctr, Cali 25574, Colombia. [Tsuboi, Takafumi] Ehime Univ, Div Malaria Res, Proteosci Ctr, Matsuyama, Ehime 7908577, Japan. RP Tsuboi, T (reprint author), Ehime Univ, Div Malaria Res, Proteosci Ctr, Matsuyama, Ehime 7908577, Japan. EM torii@m.ehime-u.ac.jp; tsuboi.takafumi.mb@ehime-u.ac.jp FU MEXT KAKENHI [23117008]; JSPS KAKENHI, Japan [26253026, 26670202]; US NIAID [U19AI089702] FX We thank the late Prof. Kazuyuki Tanabe, Laboratory of Malariology, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan for helpful discussion and comments on the manuscript. We also thank the staff of the Department of Entomology, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand, for their technical assistance, and Prof. Thomas J. Templeton for the critical reading of the manuscript. We also thank Vical Inc. for providing the VR1020 DNA vaccine plasmid and Vaxfectin (R) adjuvant. TT was supported in part by MEXT KAKENHI (23117008) and JSPS KAKENHI (26253026, 26670202), Japan. SH was supported by grant US NIAID U19AI089702. NR 51 TC 7 Z9 8 U1 1 U2 21 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X EI 1873-2518 J9 VACCINE JI Vaccine PD APR 15 PY 2015 VL 33 IS 16 BP 1901 EP 1908 DI 10.1016/j.vaccine.2015.03.008 PG 8 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA CF6JC UT WOS:000352662000002 PM 25765968 ER PT J AU Guo, JJ Reddy, KM Hirata, A Fujita, T Gazonas, GA McCauley, JW Chen, MW AF Guo, J. J. Reddy, K. Madhav Hirata, A. Fujita, T. Gazonas, G. A. McCauley, J. W. Chen, M. W. TI Sample size induced brittle-to-ductile transition of single-crystal aluminum nitride SO ACTA MATERIALIA LA English DT Article DE Ceramics; Micropillar; Plastic deformation; Size effect; Transmission electron microscopy ID ROOM-TEMPERATURE; MECHANICAL-PROPERTIES; PLASTIC-DEFORMATION; MICROMETER-SCALE; BORON-CARBIDE; COMPRESSION; CERAMICS; FRACTURE; STRENGTH; SILICON AB Ceramics are known to be mechanically hard, chemically inert and electrically insulating for many important applications. However, they usually suffer from brittleness and have moderate strength that strongly depends on their microscopic structure. In this study, we report a size induced brittle-to-ductile transition in single-crystal aluminum nitride (MN). When the specimen diameters are smaller than similar to 3-4 mu m, AlN micropillars show metal-like plastic flow under room-temperature uniaxial compression. The unprecedented plastic strain of similar to 5-10% together with the ultrahigh strength of similar to 6.7 GPa has never been achieved before. Transmission electron microscopy demonstrates that dislocations play a dominant role in the plasticity of the micro-sized AlN. (c) 2015 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved. C1 [Guo, J. J.; Reddy, K. Madhav; Hirata, A.; Fujita, T.; Chen, M. W.] Tohoku Univ, WPI Adv Inst Mat Res, Sendai, Miyagi 9808577, Japan. [Gazonas, G. A.; McCauley, J. W.] US Army, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Chen, MW (reprint author), Tohoku Univ, WPI Adv Inst Mat Res, Sendai, Miyagi 9808577, Japan. EM mwchen@wpi-aimr.tohoku.ac.jp RI Fujita, Takeshi/B-1867-2009; Chen, Mingwei/A-4855-2010; Hirata, Akihiko/A-4850-2010; guo, junjie/I-3189-2012; OI Fujita, Takeshi/0000-0002-2318-0433; Chen, Mingwei/0000-0002-2850-8872; guo, junjie/0000-0002-3414-3734; Gazonas, George/0000-0002-2715-016X FU "World Premier International (WPI) Center Initiative for Atoms, Molecules and Materials", MEXT, Japan; U.S. Army International Technology Center Pacific (ITC-PAC) of Tokyo; U. S. Army Research Lab through Johns Hopkins University FX This work was supported by "World Premier International (WPI) Center Initiative for Atoms, Molecules and Materials", MEXT, Japan; U.S. Army International Technology Center Pacific (ITC-PAC) of Tokyo; and U. S. Army Research Lab through Johns Hopkins University. NR 44 TC 1 Z9 1 U1 6 U2 42 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 1359-6454 EI 1873-2453 J9 ACTA MATER JI Acta Mater. PD APR 15 PY 2015 VL 88 BP 252 EP 259 DI 10.1016/j.actamat.2015.01.043 PG 8 WC Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Materials Science; Metallurgy & Metallurgical Engineering GA CE4KK UT WOS:000351799300024 ER PT J AU Joachim, A Nilsson, C Aboud, S Bakari, M Lyamuya, EF Robb, ML Marovich, MA Earl, P Moss, B Ochsenbauer, C Wahren, B Mhalu, F Sandstrom, E Biberfeld, G Ferrari, G Polonis, VR AF Joachim, Agricola Nilsson, Charlotta Aboud, Said Bakari, Muhammad Lyamuya, Eligius F. Robb, Merlin L. Marovich, Mary A. Earl, Patricia Moss, Bernard Ochsenbauer, Christina Wahren, Britta Mhalu, Fred Sandstrom, Eric Biberfeld, Gunnel Ferrari, Guido Polonis, Victoria R. TI Potent Functional Antibody Responses Elicited by HIV-I DNA Priming and Boosting with Heterologous HIV-1 Recombinant MVA in Healthy Tanzanian Adults SO PLOS ONE LA English DT Article ID CELL-MEDIATED CYTOTOXICITY; NEUTRALIZING ANTIBODIES; MONOCLONAL-ANTIBODIES; RHESUS MACAQUES; PROTECTIVE EFFICACY; IMMUNE-RESPONSES; VACCINE; VIRUS; INFECTION; CHALLENGE AB Vaccine-induced HIV antibodies were evaluated in serum samples collected from healthy Tanzanian volunteers participating in a phase I/II placebo-controlled double blind trial using multi-clade, multigene HIV-DNA priming and recombinant modified vaccinia Ankara (HIV-MVA) virus boosting (HIVIS03). The HIV-DNA vaccine contained plasmids expressing HIV-1 gp160 subtypes A, B, C, Rev B, Gag A, B and RTmut B, and the recombinant HIV-MVA boost expressed CRF01_AE HIV-1 Env subtype E and Gag-Pol subtype A. While no neutralizing antibodies were detected using pseudoviruses in the TZM-bl cell assay, this prime-boost vaccination induced neutralizing antibodies in 83% of HIVIS03 vaccinees when a peripheral blood mononuclear cell (PBMC) assay using luciferase reporter-infectious molecular clones (LucR-IMC) was employed. The serum neutralizing activity was significantly (but not completely) reduced upon depletion of natural killer (NK) cells from PBMC (p= 0.006), indicating a role for antibody-mediated Fcy-receptor function. High levels of antibody-dependent cellular cytotoxicity (ADCC)-mediating antibodies against CRF01_AE and/or subtype B were subsequently demonstrated in 97% of the sera of vaccinees. The magnitude of ADCC-mediating antibodies against CM235 CRF01_AE IMC-infected cells correlated with neutralizing antibodies against CM235 in the IMC/PBMC assay. In conclusion, HIV-DNA priming, followed by two HIV-MVA boosts elicited potent ADCC responses in a high proportion of Tanzanian vaccinees. Our findings highlight the potential of HIV-DNA prime HIV-MVA boost vaccines for induction of functional antibody responses and suggest this vaccine regimen and ADCC studies as potentially important new avenues in HIV vaccine development. C1 [Joachim, Agricola; Aboud, Said; Lyamuya, Eligius F.; Mhalu, Fred] Muhimbili Univ Hlth & Allied Sci, Dept Microbiol & Immunol, Dar Es Salaam, Tanzania. [Joachim, Agricola; Nilsson, Charlotta; Wahren, Britta; Biberfeld, Gunnel] Karolinska Inst, Dept Microbiol Tumor & Cell Biol, Stockholm, Sweden. [Nilsson, Charlotta; Biberfeld, Gunnel] Publ Hlth Agcy Sweden, Solna, Sweden. [Nilsson, Charlotta] Karolinska Inst, Dept Lab Med, Huddinge, Sweden. [Bakari, Muhammad] Muhimbili Univ Hlth & Allied Sci, Dept Internal Med, Dar Es Salaam, Tanzania. [Robb, Merlin L.] Henry M Jackson Fdn Adv Mil Med, Mil HIV Res Program, Bethesda, MD USA. [Marovich, Mary A.; Polonis, Victoria R.] Walter Reed Army Inst Res, Mil HIV Res Program, Silver Spring, MD USA. [Earl, Patricia; Moss, Bernard] NIAID, NIH, Bethesda, MD 20892 USA. [Ochsenbauer, Christina] Univ Alabama Birmingham, Dept Med, Birmingham, AL 35294 USA. [Sandstrom, Eric] Karolinska Inst Sodersjukhuset, Venhalsan, Stockholm, Sweden. [Ferrari, Guido] Duke Univ, Med Ctr, Dept Surg, Durham, NC 27710 USA. RP Joachim, A (reprint author), Muhimbili Univ Hlth & Allied Sci, Dept Microbiol & Immunol, Dar Es Salaam, Tanzania. EM agricolaj@muhas.ac.tz FU European Union; Swedish International Development Cooperation Agency (Sida); Swedish Embassy Tanzania; European & Developing Countries Clinical Trials Partnership (EDCTP) [CT.2006.33111.007]; Regional HIV/AIDS Team for Africa, Embassy of Sweden, Lusaka [2150012801]; Collaboration for AIDS Vaccine Discovery (CAVD) grant from the Bill & Melinda Gates Foundation [1032144]; Duke University Center for AIDS Research (CFAR) [P30 AI64518]; US Military HIV Research program; Walter Reed Army Institute of Research (WRAIR); Division of Intramural Research, NIAD, NIH FX This work was supported by the European Union, the Swedish International Development Cooperation Agency (Sida),Swedish Embassy Tanzania, the European & Developing Countries Clinical Trials Partnership (EDCTP, project code CT.2006.33111.007), and The Regional HIV/AIDS Team for Africa, Embassy of Sweden, Lusaka, jointly funded by Sweden and Norway (Sida contribution number 2150012801). Additional support was provided by the Collaboration for AIDS Vaccine Discovery (CAVD) grant from the Bill & Melinda Gates Foundation (Grant ID: 1032144), Duke University Center for AIDS Research (CFAR, grant P30 AI64518), the US Military HIV Research program, Walter Reed Army Institute of Research (WRAIR) and the Division of Intramural Research, NIAD, NIH. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 40 TC 7 Z9 8 U1 1 U2 4 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD APR 14 PY 2015 VL 10 IS 4 AR e0118486 DI 10.1371/journal.pone.0118486 PG 15 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA CG1EB UT WOS:000353014700001 PM 25874723 ER PT J AU Luk, TS de Ceglia, D Liu, S Keeler, GA Prasankumar, RP Vincenti, MA Scalora, M Sinclair, MB Campione, S AF Luk, Ting S. de Ceglia, Domenico Liu, Sheng Keeler, Gordon A. Prasankumar, Rohit P. Vincenti, Maria A. Scalora, Michael Sinclair, Michael B. Campione, Salvatore TI Enhanced third harmonic generation from the epsilon-near-zero modes of ultrathin films SO APPLIED PHYSICS LETTERS LA English DT Article ID 2ND-HARMONIC GENERATION; SURFACE-PLASMONS; 3RD-HARMONIC GENERATION; WAVE-GUIDES; THIN-FILMS; LIGHT; EMISSION; BOUNDARY; SILICON AB We experimentally demonstrate efficient third harmonic generation from an indium tin oxide nanofilm (lambda/42 thick) on a glass substrate for a pump wavelength of 1.4 mu m. A conversion efficiency of 3.3 x 10(-6) is achieved by exploiting the field enhancement properties of the epsilon-near-zero mode with an enhancement factor of 200. This nanoscale frequency conversion method is applicable to other plasmonic materials and reststrahlen materials in proximity of the longitudinal optical phonon frequencies. (c) 2015 AIP Publishing LLC. C1 [Luk, Ting S.; Liu, Sheng; Keeler, Gordon A.; Prasankumar, Rohit P.; Sinclair, Michael B.; Campione, Salvatore] Sandia Natl Labs, Albuquerque, NM 87185 USA. [Luk, Ting S.; Liu, Sheng; Campione, Salvatore] Sandia Natl Labs, Ctr Integrated Nanotechnol CINT, Albuquerque, NM 87185 USA. [de Ceglia, Domenico; Vincenti, Maria A.] Natl Res Council AMRDEC, Charles M Bowden Res Lab, Redstone Arsenal, AL 35898 USA. [Prasankumar, Rohit P.] Los Alamos Natl Lab, Ctr Integrated Nanotechnol CINT LANL, Los Alamos, NM 87545 USA. [Scalora, Michael] US Army RDECOM, AMRDEC, Charles M Bowden Res Lab, Redstone Arsenal, AL 35898 USA. RP Luk, TS (reprint author), Sandia Natl Labs, POB 5800, Albuquerque, NM 87185 USA. EM tsluk@sandia.gov OI Campione, Salvatore/0000-0003-4655-5485 FU U.S. Department of Energy, Office of Basic Energy Sciences, Division of Materials Sciences and Engineering; Laboratory Directed Research and Development program at Sandia National Laboratories; U.S. Department of Energy's National Nuclear Security Administration [DE-AC04-94AL85000]; U.S. Army Aviation and Missile Research Development and Engineering Center FX Portions of this work were supported by the U.S. Department of Energy, Office of Basic Energy Sciences, Division of Materials Sciences and Engineering, by the Laboratory Directed Research and Development program at Sandia National Laboratories, and were performed, in part, at the Center for Integrated Nanotechnologies, a U.S. Department of Energy, Office of Basic Energy Sciences user facility. Sandia National Laboratories is a multi-program laboratory managed and operated by Sandia Corporation, a wholly owned subsidiary of Lockheed Martin Corporation, for the U.S. Department of Energy's National Nuclear Security Administration under Contract No. DE-AC04-94AL85000. This research was performed while D.d.C. and M.A.V. held a National Research Council Research Associateship award at the U.S. Army Aviation and Missile Research Development and Engineering Center. NR 47 TC 13 Z9 13 U1 4 U2 24 PU AMER INST PHYSICS PI MELVILLE PA 1305 WALT WHITMAN RD, STE 300, MELVILLE, NY 11747-4501 USA SN 0003-6951 EI 1077-3118 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD APR 13 PY 2015 VL 106 IS 15 AR 151103 DI 10.1063/1.4917457 PG 5 WC Physics, Applied SC Physics GA CG3EK UT WOS:000353160700003 ER PT J AU Sangket, U Vijasika, S Noh, H Chantratita, W Klungthong, C Yoon, IK Fernandez, S Rutvisuttinunt, W AF Sangket, Unitsa Vijasika, Sukanya Noh, Hasnee Chantratita, Wasun Klungthong, Chonticha Yoon, In Kyu Fernandez, Stefan Rutvisuttinunt, Wiriya TI SNPer: An R Library for Quantitative Variant Analysis on Single Nucleotide Polymorphisms among Influenza Virus Populations SO PLOS ONE LA English DT Article ID DNA-SEQUENCING DATA; FRAMEWORK AB Influenza virus (IFV) can evolve rapidly leading to genetic drifts and shifts resulting in human and animal influenza epidemics and pandemics. The genetic shift that gave rise to the 2009 influenza A/H1N1 pandemic originated from a triple gene reassortment of avian, swine and human IFVs. More minor genetic alterations in genetic drift can lead to influenza drug resistance such as the H274Y mutation associated with oseltamivir resistance. Hence, a rapid tool to detect IFV mutations and the potential emergence of new virulent strains can better prepare us for seasonal influenza outbreaks as well as potential pandemics. Furthermore, identification of specific mutations by closely examining single nucleotide polymorphisms (SNPs) in IFV sequences is essential to classify potential genetic markers associated with potentially dangerous IFV phenotypes. In this study, we developed a novel R library called "SNPer" to analyze quantitative variants in SNPs among IFV subpopulations. The computational SNPer program was applied to three different subpopulations of published IFV genomic information. SNPer queried SNPs data and grouped the SNPs into (1) universal SNPs, (2) likely common SNPs, and (3) unique SNPs. SNPer outperformed manual visualization in terms of time and labor. SNPer took only three seconds with no errors in SNP comparison events compared with 40 hours with errors using manual visualization. The SNPer tool can accelerate the capacity to capture new and potentially dangerous IFV strains to mitigate future influenza outbreaks. C1 [Sangket, Unitsa; Vijasika, Sukanya; Noh, Hasnee] Prince Songkla Univ, Fac Sci, Dept Mol Biotechnol & Bioinformat, Hat Yai, Thailand. [Chantratita, Wasun] Mahidol Univ, Ramathibodhi Hosp, Fac Med, Dept Pathol, Bangkok 10700, Thailand. [Klungthong, Chonticha; Yoon, In Kyu; Fernandez, Stefan; Rutvisuttinunt, Wiriya] Armed Forces Res Inst Med Sci, Dept Virol, Bangkok 10400, Thailand. RP Sangket, U (reprint author), Prince Songkla Univ, Fac Sci, Dept Mol Biotechnol & Bioinformat, Hat Yai, Thailand. EM unitsa.s@psu.ac.th FU Thailand Center of Excellence for Life Sciences (TCELS) FX This work was funded by Thailand Center of Excellence for Life Sciences (TCELS). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 17 TC 1 Z9 1 U1 2 U2 10 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD APR 13 PY 2015 VL 10 IS 4 AR e0122812 DI 10.1371/journal.pone.0122812 PG 10 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA CF8XK UT WOS:000352845100105 PM 25876137 ER PT J AU Calkins, M Gates, DEA Gates, SJ Golding, WM AF Calkins, Mathew Gates, D. E. A. Gates, S. James, Jr. Golding, William M. TI Think different: applying the old macintosh mantra to the computability of the SUSY auxiliary field problem SO JOURNAL OF HIGH ENERGY PHYSICS LA English DT Article DE Space-Time Symmetries; Gauge Symmetry; Global Symmetries ID N-EXTENDED SUPERSYMMETRY; SPINNING PARTICLES; REPRESENTATION; ADINKRAS AB Starting with valise supermultiplets obtained from 0-branes plus field redefinitions, valise adinkra networks, and the "Garden Algebra," we discuss an architecture for algorithms that (starting from on-shell theories and, through a well-defined computation procedure), search for off-shell completions. We show in one dimension how to directly attack the notorious "off-shell auxiliary field" problem of supersymmetry with algorithms in the adinkra network-world formulation. C1 [Calkins, Mathew; Gates, D. E. A.; Gates, S. James, Jr.] Univ Maryland, Dept Phys, Ctr String & Particle Theory, College Pk, MD 20742 USA. [Golding, William M.] US Army, Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA. RP Calkins, M (reprint author), Univ Maryland, Dept Phys, Ctr String & Particle Theory, College Pk, MD 20742 USA. EM mathewpcalkins@gmail.com; deagates@terpmail.umd.edu; gatess@wam.umd.edu; william.m.golding2.civ@mail.mil FU National Science Foundation [PHY-0354401]; University of Maryland Center for String & Particle Theory FX We would like to acknowledge Professors Kevin Iga, Tristan Hubsch, Kory Stiffler, and Stefan Mendez-Diaz for conversations. This work was partially supported by the National Science Foundation grant PHY-0354401 and in part by the University of Maryland Center for String & Particle Theory. Additional acknowledgment is given by M. Calkins and D.E.A. Gates to the Center for String and Particle Theory, as well as recognition for their participation in 2013 & 2014 SSTPRS (Student Summer Theoretical Physics Research Session) programs. The adinkras in this work were drawn with the aid of T. Hubsch. Finally, SJG wishes to thank J. H. Schwarz for the introduction to this problem and encouragement over decades. NR 27 TC 0 Z9 0 U1 0 U2 1 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1029-8479 J9 J HIGH ENERGY PHYS JI J. High Energy Phys. PD APR 13 PY 2015 IS 4 AR 056 DI 10.1007/JHEP04(2015)056 PG 25 WC Physics, Particles & Fields SC Physics GA CF8EE UT WOS:000352787800003 ER PT J AU Chiara, CJ Weisshaar, D Janssens, RVF Tsunoda, Y Otsuka, T Harker, JL Walters, WB Recchia, F Albers, M Alcorta, M Bader, VM Baugher, T Bazin, D Berryman, JS Bertone, PF Campbell, CM Carpenter, MP Chen, J Crawford, HL David, HM Doherty, DT Gade, A Hoffman, CR Honma, M Kondev, FG Korichi, A Langer, C Larson, N Lauritsen, T Liddick, SN Lunderberg, E Macchiavelli, AO Noji, S Prokop, C Rogers, AM Seweryniak, D Shimizu, N Stroberg, SR Suchyta, S Utsuno, Y Williams, SJ Wimmer, K Zhu, S AF Chiara, C. J. Weisshaar, D. Janssens, R. V. F. Tsunoda, Y. Otsuka, T. Harker, J. L. Walters, W. B. Recchia, F. Albers, M. Alcorta, M. Bader, V. M. Baugher, T. Bazin, D. Berryman, J. S. Bertone, P. F. Campbell, C. M. Carpenter, M. P. Chen, J. Crawford, H. L. David, H. M. Doherty, D. T. Gade, A. Hoffman, C. R. Honma, M. Kondev, F. G. Korichi, A. Langer, C. Larson, N. Lauritsen, T. Liddick, S. N. Lunderberg, E. Macchiavelli, A. O. Noji, S. Prokop, C. Rogers, A. M. Seweryniak, D. Shimizu, N. Stroberg, S. R. Suchyta, S. Utsuno, Y. Williams, S. J. Wimmer, K. Zhu, S. TI Identification of deformed intruder states in semi-magic Ni-70 SO PHYSICAL REVIEW C LA English DT Article ID COINCIDENCE DATA SETS; SUBSHELL CLOSURE; ATOMIC-NUCLEI; SHELL-MODEL; NI-68; ISOTOPES; GRETINA; ARRAY; N=40 AB The structure of semi-magic Ni-70(28)42 was investigated following complementary multinucleon-transfer and secondary fragmentation reactions. Changes to the higher-spin, presumed negative-parity states based on observed gamma-ray coincidence relationships result in better agreement with shell-model calculations using effective interactions in the neutron f(5/2)pg(9/2) model space. The second 2(+) and (4(+)) states, however, can only be successfully described when proton excitations across the Z = 28 shell gap are included. Monte Carlo shell-model calculations suggest that the latter two states are part of a prolate-deformed intruder sequence, establishing an instance of shape coexistence at low excitation energies similar to that observed recently in neighboring Ni-68. C1 [Chiara, C. J.; Harker, J. L.; Walters, W. B.] Univ Maryland, Dept Chem & Biochem, College Pk, MD 20742 USA. [Chiara, C. J.; Janssens, R. V. F.; Harker, J. L.; Albers, M.; Alcorta, M.; Bertone, P. F.; Carpenter, M. P.; David, H. M.; Doherty, D. T.; Hoffman, C. R.; Korichi, A.; Lauritsen, T.; Rogers, A. M.; Seweryniak, D.; Zhu, S.] Argonne Natl Lab, Div Phys, Argonne, IL 60439 USA. [Weisshaar, D.; Otsuka, T.; Recchia, F.; Bader, V. M.; Baugher, T.; Bazin, D.; Berryman, J. S.; Gade, A.; Langer, C.; Larson, N.; Liddick, S. N.; Lunderberg, E.; Noji, S.; Prokop, C.; Stroberg, S. R.; Suchyta, S.; Williams, S. J.; Wimmer, K.] Michigan State Univ, Natl Superconducting Cyclotron Lab, E Lansing, MI 48824 USA. [Tsunoda, Y.; Otsuka, T.] Univ Tokyo, Dept Phys, Bunkyo Ku, Tokyo 1130033, Japan. [Otsuka, T.; Shimizu, N.] Univ Tokyo, Ctr Nucl Study, Bunkyo Ku, Tokyo 1130033, Japan. [Recchia, F.] Univ Padua, Dipartimento Fis & Astron, I-35131 Padua, Italy. [Bader, V. M.; Baugher, T.; Bazin, D.; Gade, A.; Lunderberg, E.; Stroberg, S. R.] Michigan State Univ, Dept Phys & Astron, E Lansing, MI 48824 USA. [Campbell, C. M.; Crawford, H. L.; Macchiavelli, A. O.] Univ Calif Berkeley, Lawrence Berkeley Natl Lab, Div Nucl Sci, Berkeley, CA 94720 USA. [Chen, J.; Kondev, F. G.] Argonne Natl Lab, Nucl Engn Div, Argonne, IL 60439 USA. [David, H. M.] Univ Edinburgh, Sch Phys & Astron, Edinburgh EH9 3JZ, Midlothian, Scotland. [Honma, M.] Univ Aizu, Ctr Math Sci, Aizu Wakamatsu, Fukushima 9658580, Japan. [Korichi, A.] CNRS, IN2P3, CSNSM, F-91405 Orsay, France. [Langer, C.] Michigan State Univ, Joint Inst Nucl Astrophys, E Lansing, MI 48824 USA. [Larson, N.; Liddick, S. N.; Prokop, C.; Suchyta, S.] Michigan State Univ, Dept Chem, E Lansing, MI 48824 USA. [Utsuno, Y.] Japan Atom Energy Agcy, Adv Sci Res Ctr, Tokai, Ibaraki 3191195, Japan. [Wimmer, K.] Cent Michigan Univ, Dept Phys, Mt Pleasant, MI 48859 USA. RP Chiara, CJ (reprint author), US Army Res Lab, Adelphi, MD 20783 USA. RI Carpenter, Michael/E-4287-2015; Gade, Alexandra/A-6850-2008; Alcorta, Martin/G-7107-2011; OTSUKA, TAKAHARU/G-5072-2014; Hoffman, Calem/H-4325-2016; Langer, Christoph/L-3422-2016; Larson, Nicole/S-5997-2016 OI Carpenter, Michael/0000-0002-3237-5734; Gade, Alexandra/0000-0001-8825-0976; Alcorta, Martin/0000-0002-6217-5004; Hoffman, Calem/0000-0001-7141-9827; Larson, Nicole/0000-0003-0292-957X FU US Department of Energy (DOE), Office of Science, Office of Nuclear Physics [DE-FG02-94ER40834, DE-AC02-06CH11357]; National Science Foundation [PHY-1102511, PHY-1430152, PHY-0822648]; DOE, National Nuclear Security Administration [DE-NA0000979]; JSPS [258994]; DOE, Office of Science; NSF [PHY-1102511]; DOE [DE-AC02-05CH11231] FX The authors thank J. P. Greene (ANL) for target preparation, I. Y. Lee (LBNL) and the GRETINA team for their efforts in making the array a reality, and the ATLAS and NSCL operations staffs. We also thank B. A. Brown for discussions and for providing the calculations using the jj44pna interaction. This material is based on work supported by the US Department of Energy (DOE), Office of Science, Office of Nuclear Physics, under Grant No. DE-FG02-94ER40834 and Contract No. DE-AC02-06CH11357; the National Science Foundation under Contract No. PHY-1102511; and by the DOE, National Nuclear Security Administration, under Award No. DE-NA0000979. C.L. acknowledges support from JINA-CEE under Grants No. PHY-1430152 and No. PHY-0822648 of the National Science Foundation. Y.T. acknowledges JSPS for Research Fellowship No. 258994. GRETINA was funded by the DOE, Office of Science. Operation of the array at NSCL was supported by the NSF under Cooperative Agreement No. PHY-1102511 (NSCL) and DOE under Grant No. DE-AC02-05CH11231 (LBNL). This research used resources of ANL's ATLAS facility, which is a DOE Office of Science user facility. NR 54 TC 14 Z9 14 U1 2 U2 11 PU AMER PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 0556-2813 EI 1089-490X J9 PHYS REV C JI Phys. Rev. C PD APR 13 PY 2015 VL 91 IS 4 AR 044309 DI 10.1103/PhysRevC.91.044309 PG 10 WC Physics, Nuclear SC Physics GA CF6SE UT WOS:000352685700001 ER PT J AU Yeh, IC Lenhart, JL Rinderspacher, BC AF Yeh, In-Chul Lenhart, Joseph L. Rinderspacher, B. Christopher TI Molecular Dynamics Simulations of Adsorption of Catechol and Related Phenolic Compounds to Alumina Surfaces SO JOURNAL OF PHYSICAL CHEMISTRY C LA English DT Article ID FORCE-FIELD; MYTILUS-EDULIS; ADHESIVE; INTERFACE; PROTEINS; FILMS; POTENTIALS; POLYMERS; BOEHMITE; MODEL AB We performed atomistically detailed molecular dynamics simulations to study adsorption behaviors of catechol, which is a key functional group in marine bioadhesives, to two different alumina surfaces in both anhydrous and aqueous conditions. In anhydrous conditions, without competing interactions from water molecules, catechol adsorbed to both hydroxylated and nonhydroxylated alumina surfaces. In aqueous conditions, catechol and several analogous phenolic compounds displaced water molecules and were strongly attracted to the nonhydroxylated alumina surface, which is more hydrophobic. When comparing the phenolic moieties near the hydroxylated alumina surface in aqueous conditions, the catechol molecules displayed the strongest adsorptions mainly through cooperative hydrogen bonding interactions of two neighboring hydroxyl groups with the surface hydroxyl groups of alumina as evidenced by the longer hydrogen bonding lifetimes and the larger number of adsorbed molecules near the surface. Insights gained from this study can be used in design of novel bioadhesives or antifouling surface coatings. C1 [Yeh, In-Chul; Lenhart, Joseph L.; Rinderspacher, B. Christopher] US Army Res Lab, Macromol Sci & Technol Branch, Mat & Mfg Sci Div, Aberdeen Proving Ground, MD 21005 USA. RP Rinderspacher, BC (reprint author), US Army Res Lab, Macromol Sci & Technol Branch, Mat & Mfg Sci Div, Aberdeen Proving Ground, MD 21005 USA. EM berend.c.rinderspacher.civ@mail.mil FU Postgraduate Research Participation Program at the U.S. Army Research Laboratory (ARL) FX This work was supported in part by an appointment to the Postgraduate Research Participation Program at the U.S. Army Research Laboratory (ARL) administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the U.S. Department of Energy and ARL. The DoD HPC Modernization Office supported this project by supplying supercomputer time under the Computing Challenge Project CSM. We thank Drs. Joshua Orlicki and Daniel Knorr for helpful discussions and comments on our work. NR 52 TC 4 Z9 4 U1 11 U2 57 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1932-7447 J9 J PHYS CHEM C JI J. Phys. Chem. C PD APR 9 PY 2015 VL 119 IS 14 BP 7721 EP 7731 DI 10.1021/jp512780s PG 11 WC Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary SC Chemistry; Science & Technology - Other Topics; Materials Science GA CF8PC UT WOS:000352823300019 ER PT J AU Childs, JD Fritz, JM Wu, SS Flynn, TW Wainner, RS Robertson, EK Kim, FS George, SZ AF Childs, John D. Fritz, Julie M. Wu, Samuel S. Flynn, Timothy W. Wainner, Robert S. Robertson, Eric K. Kim, Forest S. George, Steven Z. TI Implications of early and guideline adherent physical therapy for low back pain on utilization and costs SO BMC HEALTH SERVICES RESEARCH LA English DT Article DE Guideline adherence; Low back pain; Physical therapy; Timing; Utilization and costs ID CLINICAL-PRACTICE GUIDELINE; PRIMARY-CARE; SOCIETY/AMERICAN COLLEGE; MILITARY PERSONNEL; UNITED-STATES; HEALTH-CARE; DISABILITY; MANAGEMENT; RADICULOPATHY; EXPENDITURES AB Background: Initial management decisions following a new episode of low back pain (LBP) are thought to have profound implications for health care utilization and costs. The purpose of this study was to evaluate the impact of early and guideline adherent physical therapy for low back pain on utilization and costs within the Military Health System (MHS). Methods: Patients presenting to a primary care setting with a new complaint of LBP from January 1, 2007 to December 31, 2009 were identified from the MHS Management Analysis and Reporting Tool. Descriptive statistics, utilization, and costs were examined on the basis of timing of referral to physical therapy and adherence to practice guidelines over a 2-year period. Utilization outcomes (advanced imaging, lumbar injections or surgery, and opioid use) were compared using adjusted odds ratios with 99% confidence intervals. Total LBP-related health care costs over the 2-year follow-up were compared using linear regression models. Results: 753,450 eligible patients with a primary care visit for LBP between 18-60 years of age were considered. Physical therapy was utilized by 16.3% (n = 122,723) of patients, with 24.0% (n = 17,175) of those receiving early physical therapy that was adherent to recommendations for active treatment. Early referral to guideline adherent physical therapy was associated with significantly lower utilization for all outcomes and 60% lower total LBP-related costs. Conclusions: The potential for cost savings in the MHS from early guideline adherent physical therapy may be substantial. These results also extend the findings from similar studies in civilian settings by demonstrating an association between early guideline adherent care and utilization and costs in a single payer health system. Future research is necessary to examine which patients with LBP benefit early physical therapy and determine strategies for providing early guideline adherent care. C1 [Childs, John D.] US Army, Baylor Univ, Army Med Dept Ctr & Sch, Doctoral Program Phys Therapy, Ft Sam Houston, TX 78234 USA. [Fritz, Julie M.] Univ Utah, Dept Phys Therapy, Salt Lake City, UT 84108 USA. [Wu, Samuel S.] Univ Florida, Coll Publ Hlth & Hlth Profess, Dept Hlth Serv Res Management & Policy, Gainesville, FL 32610 USA. [Flynn, Timothy W.; Wainner, Robert S.] South Coll, FIM Sch Phys Therapy, Knoxville, TN 37909 USA. [Robertson, Eric K.] Univ Texas El Paso, Doctor Phys Therapy Program, El Paso, TX 79968 USA. [Kim, Forest S.] US Army Baylor, US Army Med Dept Ctr & Sch, MHA MBA Program, San Antonio, TX 78234 USA. [George, Steven Z.] Univ Florida, Dept Phys Therapy, Brooks PHHP Res Collaborat, Gainesville, FL 32610 USA. RP Childs, JD (reprint author), US Army, Baylor Univ, Army Med Dept Ctr & Sch, Doctoral Program Phys Therapy, 3151 Scott Rd,Rm 2307,JBSA Ft, Ft Sam Houston, TX 78234 USA. EM childsjd@gmail.com FU Texas State University; Air Force Medical Service FX The authors would like to acknowledge Maurine R. Tapscott, Senior Health Systems Specialist, Program Analysis & Evaluation, HQ MEDCOM A&E Division for her efforts in extracting the data and providing the data dictionary for the data analysis. This study was funded by intramural grant programs at Texas State University and the Air Force Medical Service. The funding agencies played no role in the study design, data collection, analysis, interpretation of data, writing of manuscript, or decision to submit the manuscript for publication. NR 29 TC 14 Z9 14 U1 0 U2 7 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1472-6963 J9 BMC HEALTH SERV RES JI BMC Health Serv. Res. PD APR 9 PY 2015 VL 15 AR 150 DI 10.1186/s12913-015-0830-3 PG 10 WC Health Care Sciences & Services SC Health Care Sciences & Services GA CF5OK UT WOS:000352606400001 PM 25880898 ER PT J AU Wang, H Nandigana, VVR Jo, KD Aluru, NR Timperman, AT AF Wang, Han Nandigana, Vishal V. R. Jo, Kyoo Dong Aluru, Narayana R. Timperman, Aaron T. TI Controlling the Ionic Current Rectification Factor of a Nanofluidic/Microfluidic Interface with Symmetric Nanocapillary Interconnects SO ANALYTICAL CHEMISTRY LA English DT Article ID SINGLE CONICAL NANOPORES; NANOFLUIDIC DIODE; TRANSPORT-PROPERTIES; DEVICES; MEMBRANE; SYSTEM; CHARGE AB The current rectification factor can be tailored by changing the degree of asymmetry between the fluid baths on opposite sides of a nanocapillary membrane (NCM). A symmetric device with symmetric fluid baths connected to opposite sides of the NCM did not rectify ionic current; while a NCM connected between fluid baths with a 32-fold difference in cross-sectional area produced a rectification factor of 75. The data suggests that the primary mechanism for the current rectification is the change in cross-sectional area of the fluid baths and the polarity dependent propagation of the enriched and depleted concentration polarization (CP) zones into these regions. An additional contribution to the increasing rectification factor with increasing bath asymmetry appears to be a result of electroconvection in the macropore, with inside diameters (IDs) of 625 and 850-mu m. Power spectral density (PSD) analysis reveals chaotic oscillations that are consistent with electroconvection in the I-t data of the 625 and 850-mu m ID macropore devices. In the ON state, current rectification keeps ionic transport toward the NCM high, increasing the speed of processes like sample enrichment. A simple means is provided to fabricate fluidic diodes with tailored current rectification factors. C1 [Jo, Kyoo Dong; Timperman, Aaron T.] US Army Corps Engn, Construct Engn Res Lab, Champaign, IL 61826 USA. [Wang, Han] W Virginia Univ, Dept Chem, Morgantown, WV 26505 USA. [Nandigana, Vishal V. R.; Aluru, Narayana R.] Univ Illinois, Beckman Inst Adv Sci & Technol, Urbana, IL 61801 USA. RP Timperman, AT (reprint author), US Army Corps Engn, Construct Engn Res Lab, 2902 Newmark Dr, Champaign, IL 61826 USA. EM aaron.timperman@usace.army.mil RI Aluru, N/A-4617-2014 FU U.S. Army Environmental Quality and Installations Basic Research Program FX This publication represents research that was funded by the U.S. Army Environmental Quality and Installations Basic Research Program. NR 38 TC 4 Z9 4 U1 2 U2 16 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0003-2700 EI 1520-6882 J9 ANAL CHEM JI Anal. Chem. PD APR 7 PY 2015 VL 87 IS 7 BP 3598 EP 3605 DI 10.1021/ac5019638 PG 8 WC Chemistry, Analytical SC Chemistry GA CF6ID UT WOS:000352659500009 PM 25803122 ER PT J AU Petrie, JR Wieland, KA Timmerwilke, JM Barron, SC Burke, RA Newburgh, GA Burnette, JE Fischer, GA Edelstein, AS AF Petrie, J. R. Wieland, K. A. Timmerwilke, J. M. Barron, S. C. Burke, R. A. Newburgh, G. A. Burnette, J. E. Fischer, G. A. Edelstein, A. S. TI A multi-state magnetic memory dependent on the permeability of Metglas SO APPLIED PHYSICS LETTERS LA English DT Article ID BULK METALLIC GLASSES; AMORPHOUS-ALLOYS; CRYSTALLIZATION; EVOLUTION; BEHAVIOR; KINETICS AB A three-state magnetic memory was developed based on differences in the magnetic permeability of a soft ferromagnetic media, Metglas 2826MB (Fe40Ni38Mo4B18). By heating bits of a 250 nm thick Metglas film with 70-100 mW of laser power, we were able to tune the local microstructure, and hence, the permeability. Ternary memory states were created by using lower laser power to enhance the initial permeability through localized atomic rearrangement and higher power to reduce the permeability through crystallization. The permeability of the bits was read by detecting variations in an external 32 Oe probe field within 10 mu m of the media via a magnetic tunnel junction read head. Compared to data based on remanent magnetization, these multi-permeability bits have enhanced insensitivity to unexpected field and temperature changes. We found that data was not corrupted after exposure to fields of 1 T or temperatures of 423 K, indicating the effectiveness of this multi-state approach for safely storing large amounts of data. (C) 2015 AIP Publishing LLC. C1 [Petrie, J. R.; Wieland, K. A.; Timmerwilke, J. M.; Burke, R. A.; Newburgh, G. A.; Fischer, G. A.; Edelstein, A. S.] US Army Res Lab, Adelphi, MD 20783 USA. [Barron, S. C.] Natl Inst Stand & Technol, Gaithersburg, MD 20899 USA. [Burnette, J. E.] Spin Transfer Technol, Boston, MA 02110 USA. RP Petrie, JR (reprint author), US Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. NR 33 TC 1 Z9 1 U1 1 U2 21 PU AMER INST PHYSICS PI MELVILLE PA 1305 WALT WHITMAN RD, STE 300, MELVILLE, NY 11747-4501 USA SN 0003-6951 EI 1077-3118 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD APR 6 PY 2015 VL 106 IS 14 AR 142403 DI 10.1063/1.4917247 PG 4 WC Physics, Applied SC Physics GA CF8OF UT WOS:000352820700023 ER PT J AU Vasan, S Rerks-Ngarm, S Gilbert, P Haynes, B Nitayapan, S Pitisuttihum, P Kaewkungwal, J Excler, JL Robb, M Michael, N Kim, J O'Connell, R AF Vasan, Sandhya Rerks-Ngarm, Supachai Gilbert, Peter Haynes, Barton Nitayapan, Sorachai Pitisuttihum, Punnee Kaewkungwal, Jaranit Excler, Jean-Louis Robb, Merlin Michael, Nelson Kim, Jerome O'Connell, Robert TI Letter to the Editor on: The RV144 vaccine regimen was not associated with enhancement of infection SO HUMAN VACCINES & IMMUNOTHERAPEUTICS LA English DT Letter ID ALVAC-HIV VCP1521; EFFICACY TRIAL; THAILAND; AIDSVAX C1 [Vasan, Sandhya; O'Connell, Robert] USAMC AFRIMS, US Mil HIV Res Program, Armed Forces Res Inst Med Sci, US Army Component, Bangkok, Thailand. [Rerks-Ngarm, Supachai] Minist Publ Hlth, Dept Dis Control, Nonthaburi, Thailand. [Gilbert, Peter] Fred Hutchinson Canc Res Ctr, Stat Ctr HIV AIDS Res & Prevent, Seattle, WA 98104 USA. [Haynes, Barton] Duke Univ, Sch Med, Human Vaccine Inst, Durham, NC USA. [Haynes, Barton] Duke Univ, Sch Med, Dept Med, Durham, NC 27706 USA. [Haynes, Barton] Duke Univ, Sch Med, Dept Immunol, Durham, NC USA. [Nitayapan, Sorachai] Armed Forces Res Inst Med Sci, Royal Thai Army Component, Bangkok 10400, Thailand. [Pitisuttihum, Punnee; Kaewkungwal, Jaranit] Mahidol Univ, Fac Trop Med, Bangkok, Thailand. [Excler, Jean-Louis; Robb, Merlin; Michael, Nelson; Kim, Jerome] US Mil Res Program, Vaccine Clin Dev, Bethesda, MD USA. RP O'Connell, R (reprint author), USAMC AFRIMS, US Mil HIV Res Program, Armed Forces Res Inst Med Sci, US Army Component, Bangkok, Thailand. EM robert.oconnell@afrims.org NR 7 TC 1 Z9 1 U1 1 U2 3 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA SN 2164-5515 EI 2164-554X J9 HUM VACC IMMUNOTHER JI Human Vaccines Immunother. PD APR 3 PY 2015 VL 11 IS 4 BP 1036 EP 1037 DI 10.1080/21645515.2015.1010970 PG 2 WC Biotechnology & Applied Microbiology; Immunology SC Biotechnology & Applied Microbiology; Immunology GA CH3WP UT WOS:000353961900037 PM 25746053 ER PT J AU Perliger, A Zaidise, E AF Perliger, Arie Zaidise, Eran TI The Peculiar Victory of The National Camp in the 2013 Israeli Election SO ISRAEL AFFAIRS LA English DT Article DE far right; Israeli elections 2013; Israeli right; 19th Knesset; settlers movement ID PARTIES AB This article argues that attempts to characterize the outcome of the elections to the 19th Knesset as a defeat of the Israeli right are misleading. By using a three-dimensional analysis of the ideological makeup of the Knesset, based on the ideological manifestos of the parties, the socio-demographic profiles of Knesset members and analyses of election results utilizing electoral data and socio-demographic data obtained from Israel's Central Bureau of Statistics (CBS), the article claims that the 19th Knesset is no less right-leaning than its predecessor. Hence, contrary to some commentators in both the media and academia, the 2013 elections represent a true landmark for the settlers. For the first time since the movement appeared in the 1970s, it managed to obtain a solid base in the Knesset. C1 [Perliger, Arie] US Mil Acad, Dept Social Sci, West Point, NY 10996 USA. [Zaidise, Eran] Western Galilee Coll, Dept Polit Sci, Akko, Israel. RP Perliger, A (reprint author), US Mil Acad, Dept Social Sci, West Point, NY 10996 USA. EM aperliger@gmail.com NR 24 TC 1 Z9 1 U1 0 U2 1 PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND SN 1353-7121 EI 1743-9086 J9 ISR AFF JI Isr. Aff. PD APR 3 PY 2015 VL 21 IS 2 SI SI BP 195 EP 208 DI 10.1080/13537121.2015.1008243 PG 14 WC Area Studies SC Area Studies GA CD2BT UT WOS:000350879400002 ER PT J AU Guillen, J Lichiere, J Rabah, N Beitzel, BF Canard, B Coutard, B AF Guillen, Jaime Lichiere, Julie Rabah, Nadia Beitzel, Brett F. Canard, Bruno Coutard, Bruno TI Structural and biophysical analysis of sequence insertions in the Venezuelan Equine Encephalitis Virus macro domain SO VIRUS RESEARCH LA English DT Article DE Alphavirus; Non-structural protein; Macro domain; Sequence insertion; Structure; Biophysical studies ID STRAND RNA-SYNTHESIS; REPLICASE PROTEIN NSP2; SINDBIS-VIRUS; MINUS-STRAND; NONSTRUCTURAL PROTEIN; IN-VITRO; IDENTIFICATION; MUTATIONS; CHIKUNGUNYA; PHOSPHORYLATION AB Random transposon insertions in viral genomes can be used to reveal genomic regions important for virus replication. We used these genomic data to evaluate at the protein level the effect of such insertions on the Venezuelan Equine Encephalitis Virus nsP3 macro domain. The structural analysis showed that transposon insertions occur mainly in loops connecting the secondary structure elements. Some of the insertions leading to a temperature sensitive viral phenotype (ts) are close to the cleavage site between nsP2 and nsP3 or the ADP-ribose binding site, two important functions of the macro domain. Using four mutants mimicking the transposon insertions, we confirmed that these insertions can affect the macro domain properties without disrupting the overall structure of the protein. (C) 2015 Elsevier B.V. All rights reserved. C1 [Guillen, Jaime; Lichiere, Julie; Rabah, Nadia; Canard, Bruno; Coutard, Bruno] CNRS, AFMB UMR 7257, F-13288 Marseille, France. [Guillen, Jaime; Lichiere, Julie; Rabah, Nadia; Canard, Bruno; Coutard, Bruno] Aix Marseille Univ, AFMB UMR 7257, F-13288 Marseille 09, France. [Beitzel, Brett F.] US Army, Ctr Genome Sci, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. RP Coutard, B (reprint author), Aix Marseille Univ, AFMB UMR 7257, F-13288 Marseille 09, France. EM bruno.coutard@afmb.univ-mrs.fr RI Guillen, Jaime/K-2892-2014 OI Guillen, Jaime/0000-0001-7415-1512 FU European Union [260644]; MEC [BFS-2010-1217]; Intra-European Marie Curie fellowship [299753] FX This work was supported by the European Union Seventh Framework Programme FP7/2007-2013 [Project SILVER Grant 260644]. J.G. was recipient of a postdoctoral fellowship from MEC (BFS-2010-1217) and an Intra-European Marie Curie fellowship (FP7-PEOPLE-2011-IEF, no 299753). NR 42 TC 0 Z9 0 U1 0 U2 2 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0168-1702 EI 1872-7492 J9 VIRUS RES JI Virus Res. PD APR 2 PY 2015 VL 201 BP 94 EP 100 DI 10.1016/j.virusres.2015.02.018 PG 7 WC Virology SC Virology GA CI8MP UT WOS:000355026700013 PM 25725151 ER PT J AU Maxwell, P Maciejewski, AA Siegel, HJ Potter, J Smith, J AF Maxwell, Paul Maciejewski, Anthony A. Siegel, Howard Jay Potter, Jerry Smith, Jay TI Dynamic rescheduling heuristics for military village search environments SO JOURNAL OF DEFENSE MODELING AND SIMULATION-APPLICATIONS METHODOLOGY TECHNOLOGY-JDMS LA English DT Article DE resource allocation; robustness; stochastic; robust resource allocation; dynamic rescheduling; village search ID TRAVELING SALESMAN PROBLEM; VEHICLE-ROUTING PROBLEM; RESOURCE-ALLOCATION; GENETIC ALGORITHMS; INDEPENDENT TASKS; ROBUSTNESS; SYSTEMS; MODEL AB On the modern battlefield cordon and search missions (also known as village searches) are conducted daily. Creating resource allocations that link search teams (e.g. soldiers, robots, unmanned aerial vehicles, military working dogs) to target buildings is difficult and time consuming in the static planning environment and is even more challenging in a time-constrained dynamic environment. Conducting dynamic resource allocation during the execution of a military village search mission is beneficial especially when the time to develop a static plan is limited and hence the quality of the plan is relatively poor. Dynamic heuristics can help improve the static plan because they are able to incorporate current state information that is unavailable prior to mission execution and thus produce more accurate results than static heuristics alone can achieve. There are currently no automated means to create these dynamic resource allocations for military use. Using robustness concepts, this paper proposes and compares dynamic resource allocation heuristics that create mission plans that are resilient against uncertainty in the environment and that save valuable time for military planning staff. C1 [Maxwell, Paul] US Mil Acad, Dept Elect Engn & Comp Sci, West Point, NY 10996 USA. [Maciejewski, Anthony A.; Siegel, Howard Jay; Potter, Jerry] Colorado State Univ, Dept Elect & Comp Engn, Ft Collins, CO 80523 USA. [Smith, Jay] Lagrange Syst Inc, Boulder, CO USA. RP Maxwell, P (reprint author), US Mil Acad, Dept Elect Engn & Comp Sci, West Point, NY 10996 USA. EM paul.maxwell@us.army.mil NR 33 TC 0 Z9 0 U1 0 U2 1 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 1548-5129 EI 1557-380X J9 J DEF MODEL SIMUL-AP JI J. Def. Model. Simul.-Appl. Methodol. Technol.-JDMS PD APR PY 2015 VL 12 IS 2 BP 139 EP 156 DI 10.1177/1548512913518665 PG 18 WC Engineering, Multidisciplinary SC Engineering GA CV7YU UT WOS:000364494100005 ER PT J AU Reddy, KR Beavers, KL Gordon, S Harrison, S Reau, N Yozviak, J DeLedinghen, V Conway, B Tse, E Bhore, R Boparai, N Hughes, E Swenson, ES Yin, PD AF Reddy, K. Rajender Beavers, K. L. Gordon, S. Harrison, S. Reau, N. Yozviak, J. DeLedinghen, V. Conway, B. Tse, E. Bhore, R. Boparai, N. Hughes, E. Swenson, E. S. Yin, P. D. TI EFFECT OF BASELINE FACTORS ON RESPONSE TO THE FIXED-DOSE COMBINATION OF DACLATASVIR (DCV), ASUNAPREVIR (ASV) AND BECLABUVIR (BCV) IN NON-CIRRHOTIC PATIENTS WITH HCV GENOTYPE 1 INFECTION SO JOURNAL OF HEPATOLOGY LA English DT Meeting Abstract CT 50th International Liver Congress of the European-Association-for-the-Study-of-the-Liver CY APR 22-26, 2015 CL Vienna, AUSTRIA SP European Assoc Study Liver C1 [Reddy, K. Rajender] Univ Penn, Philadelphia, PA 19104 USA. [Beavers, K. L.] Med Univ S Carolina, Charleston, SC USA. [Gordon, S.] Henry Ford Hlth Syst, Detroit, MI USA. [Harrison, S.] Brooke Army Med Ctr, San Antonio, TX USA. [Reau, N.] Univ Chicago, Med Ctr, Chicago, IL 60637 USA. [Yozviak, J.] Lehigh Valley Hlth Network, Allentown, PA USA. [DeLedinghen, V.] Hop Haut Leveque, Pessac, France. [Conway, B.] Vancouver Infect Dis Ctr, Vancouver, BC, Canada. [Tse, E.] Royal Adelaide Hosp, Adelaide, SA 5000, Australia. [Bhore, R.; Boparai, N.; Hughes, E.] Bristol Myers Squibb Res & Dev, Princeton, NJ USA. [Swenson, E. S.; Yin, P. D.] Bristol Myers Squibb Res & Dev, Wallingford, CT USA. EM adrienne.tracey@articulatescience.com NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0168-8278 EI 1600-0641 J9 J HEPATOL JI J. Hepatol. PD APR PY 2015 VL 62 SU 2 MA P0889 BP S676 EP S677 PG 2 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA CT5EL UT WOS:000362830900085 ER PT J AU Audet, G Quinn, C Leon, L AF Audet, Gerald Quinn, Carrie Leon, Lisa TI Point-of-care cTnI Tests Accurately Predict Heat Stroke Severity; Proof of Concept for a Heat Stroke Field Test SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology Meeting CY MAR 28-APR 01, 2015 CL Boston, MA SP Amer Assoc Anatomists, Amer Physiol Soc, Amer Soc Biochem & Mol Biol, ASIP, ASN, ASPET C1 [Audet, Gerald; Quinn, Carrie; Leon, Lisa] US Army Res Inst Environm Med, Thermal Mt Med, Natick, MA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 EI 1530-6860 J9 FASEB J JI Faseb J. PD APR PY 2015 VL 29 SU 1 MA 993.14 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA CS0BT UT WOS:000361722707221 ER PT J AU Barr, J Dubick, M Bowman, P AF Barr, Johnny Dubick, Michael Bowman, Phillip TI In Vitro Hypoxia/Reoxygenation Modeling of Ischemia/Reperfusion Injury Using Glucose Oxidase in Human Cells SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology Meeting CY MAR 28-APR 01, 2015 CL Boston, MA SP Amer Assoc Anatomists, Amer Physiol Soc, Amer Soc Biochem & Mol Biol, ASIP, ASN, ASPET C1 [Barr, Johnny; Dubick, Michael; Bowman, Phillip] US Army Inst Surg Res, Damage Control Resuscitat, San Antonio, TX USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 EI 1530-6860 J9 FASEB J JI Faseb J. PD APR PY 2015 VL 29 SU 1 MA 977.4 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA CS0BT UT WOS:000361722707071 ER PT J AU Boeri, M Kasten, S Cerasoli, D AF Boeri, Michael Kasten, Shane Cerasoli, Douglas TI Inhibition of Human Acetylcholinesterase by Enantiomers of V-Type Chemical Warfare Nerve Agents and Analogs SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology Meeting CY MAR 28-APR 01, 2015 CL Boston, MA SP Amer Assoc Anatomists, Amer Physiol Soc, Amer Soc Biochem & Mol Biol, ASIP, ASN, ASPET C1 [Boeri, Michael; Kasten, Shane; Cerasoli, Douglas] US Army, Med Res Inst Chem Def, Div Res, Arlington, VA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 EI 1530-6860 J9 FASEB J JI Faseb J. PD APR PY 2015 VL 29 SU 1 MA 721.4 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA CS0BT UT WOS:000361722701234 ER PT J AU Brunelle, A Blum-Johnston, C Wee, C Blood, Q Wilson, R Romero, M Francis, M Taylor, M Longo, L Wilson, S AF Brunelle, Alexander Blum-Johnston, Carla Wee, Chelsea Blood, Quintin Wilson, Rachael Romero, Monica Francis, Michael Taylor, Mark Longo, Lawrence Wilson, Sean TI High altitude Gestation and Prenatal Programming of Bradykinin Induced Pulmonary Endothelial Ca2+ Responses and Arterial Vasorelaxation in Fetal and Newborn Lamb SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology Meeting CY MAR 28-APR 01, 2015 CL Boston, MA SP Amer Assoc Anatomists, Amer Physiol Soc, Amer Soc Biochem & Mol Biol, ASIP, ASN, ASPET C1 [Brunelle, Alexander; Blum-Johnston, Carla; Wee, Chelsea; Blood, Quintin; Wilson, Rachael; Longo, Lawrence; Wilson, Sean] Loma Linda Univ, SOM, Ctr Perinatal Biol, Loma Linda, CA 92350 USA. [Romero, Monica; Wilson, Sean] Loma Linda Univ, LLUSOM, Adv Imaging & Microscopy Core, Loma Linda, CA 92350 USA. [Francis, Michael; Taylor, Mark] USA, Coll Med, Physiol, Mobile, AL USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 EI 1530-6860 J9 FASEB J JI Faseb J. PD APR PY 2015 VL 29 SU 1 MA 1051.1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA CS0BT UT WOS:000361722708126 ER PT J AU Cadieux, CL Wang, HY Zhang, YC Koenig, J Shih, TM McDonough, J Koh, J Cerasoli, D AF Cadieux, C. Linn Wang, Haoyu Zhang, Yuchen Koenig, Jeffrey Shih, Tsung-Ming McDonough, John Koh, John Cerasoli, Douglas TI Phosphonylated Acetylcholinesterase: Probing the Mechanism of a Small Molecule Reactivator SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology Meeting CY MAR 28-APR 01, 2015 CL Boston, MA SP Amer Assoc Anatomists, Amer Physiol Soc, Amer Soc Biochem & Mol Biol, ASIP, ASN, ASPET C1 [Cadieux, C. Linn; Koenig, Jeffrey; Shih, Tsung-Ming; McDonough, John; Cerasoli, Douglas] US Army, Med Res Inst Chem Def, Div Res, Aberdeen Proving Ground, MD 21010 USA. [Wang, Haoyu; Zhang, Yuchen; Koh, John] Univ Delaware, Dept Chem & Biochem, Newark, DE 19716 USA. NR 0 TC 0 Z9 0 U1 3 U2 3 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 EI 1530-6860 J9 FASEB J JI Faseb J. PD APR PY 2015 VL 29 SU 1 MA 721.7 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA CS0BT UT WOS:000361722701237 ER PT J AU Dubick, M Barr, J Bowman, P AF Dubick, Michael Barr, Johnny Bowman, Phillip TI Mechanism of Cell Death Induced by in Vitro Hypoxia/Reoxygenation Using Glucose Oxidase in Human Cells SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology Meeting CY MAR 28-APR 01, 2015 CL Boston, MA SP Amer Assoc Anatomists, Amer Physiol Soc, Amer Soc Biochem & Mol Biol, ASIP, ASN, ASPET C1 [Dubick, Michael; Barr, Johnny; Bowman, Phillip] US Army Inst Surg Res, Damage Control Resuscitat, San Antonio, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 EI 1530-6860 J9 FASEB J JI Faseb J. PD APR PY 2015 VL 29 SU 1 MA 977.3 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA CS0BT UT WOS:000361722707070 ER PT J AU Freese, E Gist, N Acitelli, R McConnell, W Beck, C Hausman, D Murrow, J Cureton, K Evans, E AF Freese, Eric Gist, Nicholas Acitelli, Rachelle McConnell, Whitni Beck, Catherine Hausman, Dorothy Murrow, Jonathan Cureton, Kirk Evans, Ellen TI Acute and Chronic Effects of Sprint Interval Training on Postprandial Lipemia in Women At-Risk for Metabolic Syndrome SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology Meeting CY MAR 28-APR 01, 2015 CL Boston, MA SP Amer Assoc Anatomists, Amer Physiol Soc, Amer Soc Biochem & Mol Biol, ASIP, ASN, ASPET C1 [Freese, Eric; Acitelli, Rachelle; McConnell, Whitni; Beck, Catherine; Cureton, Kirk; Evans, Ellen] Univ Georgia, Kinesiol, Athens, GA 30602 USA. [Gist, Nicholas] US Mil Acad, Phys Educ, West Point, NY 10996 USA. [Hausman, Dorothy] Univ Georgia, Foods & Nutr, Athens, GA 30602 USA. [Murrow, Jonathan] Georgia Regents Univ Univ Georgia Med Partnership, Athens, GA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 EI 1530-6860 J9 FASEB J JI Faseb J. PD APR PY 2015 VL 29 SU 1 MA 1055.7 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA CS0BT UT WOS:000361722708165 ER PT J AU Hinojosa-Laborde, C Mulligan, J Grudic, G Convertino, V AF Hinojosa-Laborde, Carmen Mulligan, Jane Grudic, Greg Convertino, Victor TI Comparison of Compensatory Reserve Index during Lower Body Negative Pressure and Hemorrhage SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology Meeting CY MAR 28-APR 01, 2015 CL Boston, MA SP Amer Assoc Anatomists, Amer Physiol Soc, Amer Soc Biochem & Mol Biol, ASIP, ASN, ASPET C1 [Hinojosa-Laborde, Carmen; Convertino, Victor] US Army Inst Surg Res, Tact Combat Casualty Care Res, Ft Sam Houston, TX USA. [Mulligan, Jane; Grudic, Greg] Flashback Technol Inc, R&D, Boulder, CO USA. NR 0 TC 0 Z9 0 U1 2 U2 2 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 EI 1530-6860 J9 FASEB J JI Faseb J. PD APR PY 2015 VL 29 SU 1 MA 800.8 PG 2 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA CS0BT UT WOS:000361722703044 ER PT J AU Jahns, L Stote, K Madanat, H Cole, R AF Jahns, Lisa Stote, Kim Madanat, Hala Cole, Renee TI Women's Motivations for Eating SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology Meeting CY MAR 28-APR 01, 2015 CL Boston, MA SP Amer Assoc Anatomists, Amer Physiol Soc, Amer Soc Biochem & Mol Biol, ASIP, ASN, ASPET C1 [Jahns, Lisa] ARS, GFHNRC, USDA, New York, NY USA. [Stote, Kim] SUNY Empire State Coll, Hlth Sci, New York, NY USA. [Madanat, Hala] San Diego State Univ, Grad Sch Publ Hlth, San Diego, CA 92182 USA. [Cole, Renee] US Army, Mil Nutr Div, Environm Med Res Inst, Washington, DC USA. NR 0 TC 0 Z9 0 U1 2 U2 2 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 EI 1530-6860 J9 FASEB J JI Faseb J. PD APR PY 2015 VL 29 SU 1 MA 736.20 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA CS0BT UT WOS:000361722702064 ER PT J AU Klemcke, H Bynum, J Bowman, P AF Klemcke, H. Bynum, J. Bowman, P. TI Cardiac mRNA Expression in Inbred Rat Strains Divergent in Survival Time after Hemorrhage SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology Meeting CY MAR 28-APR 01, 2015 CL Boston, MA SP Amer Assoc Anatomists, Amer Physiol Soc, Amer Soc Biochem & Mol Biol, ASIP, ASN, ASPET C1 [Klemcke, H.; Bynum, J.; Bowman, P.] US Army Inst Surg Res, DCR, Ft Sam Houston, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 EI 1530-6860 J9 FASEB J JI Faseb J. PD APR PY 2015 VL 29 SU 1 MA 665.6 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA CS0BT UT WOS:000361722700030 ER PT J AU Leon, L Dineen, S AF Leon, Lisa Dineen, Shauna TI Prior Viral Infection Increases Heat Stroke Severity in Mice SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology Meeting CY MAR 28-APR 01, 2015 CL Boston, MA SP Amer Assoc Anatomists, Amer Physiol Soc, Amer Soc Biochem & Mol Biol, ASIP, ASN, ASPET C1 [Leon, Lisa; Dineen, Shauna] US Army Res Inst Environm Med, Thermal Mt Med Div, Natick, MA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 EI 1530-6860 J9 FASEB J JI Faseb J. PD APR PY 2015 VL 29 SU 1 MA 993.10 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA CS0BT UT WOS:000361722707217 ER PT J AU McClung, H Margolis, L Murphy, N Lin, G Hydren, J Davis, B Young, A Pasiakos, S AF McClung, Holly Margolis, Lee Murphy, Nancy Lin, Gregory Hydren, Jay Davis, Betty Young, Andrew Pasiakos, Stefan TI Net Protein Balance after Load Carriage Exercise is Enhanced by Amino Acid Supplementation SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology Meeting CY MAR 28-APR 01, 2015 CL Boston, MA SP Amer Assoc Anatomists, Amer Physiol Soc, Amer Soc Biochem & Mol Biol, ASIP, ASN, ASPET C1 [McClung, Holly; Margolis, Lee; Murphy, Nancy; Lin, Gregory; Hydren, Jay; Young, Andrew; Pasiakos, Stefan] US Army Res Inst Environm Med, Mil Nutr Div, Natick, MA USA. [Davis, Betty] US Army Natick Soldier Res Dev & Engn, Combat Feeding Directorate, Natick, MA USA. RI Hydren, Jay/H-3654-2016 OI Hydren, Jay/0000-0001-9385-8898 NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 EI 1530-6860 J9 FASEB J JI Faseb J. PD APR PY 2015 VL 29 SU 1 MA 742.4 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA CS0BT UT WOS:000361722702133 ER PT J AU Muhie, S Gautam, A Chakraborty, N Hammamieh, R Meyerhoff, J Jett, M AF Muhie, Seid Gautam, Aarti Chakraborty, Nabarun Hammamieh, Rasha Meyerhoff, James Jett, Marti TI Molecular Indicators of Inflammation along Pathological Time-line of Post-traumatic Stress Disorder SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology Meeting CY MAR 28-APR 01, 2015 CL Boston, MA SP Amer Assoc Anatomists, Amer Physiol Soc, Amer Soc Biochem & Mol Biol, ASIP, ASN, ASPET C1 [Muhie, Seid] Frederick Natl Lab Canc Res, Adv Biomed Comp Ctr, Ft Detrick, MD USA. [Gautam, Aarti; Chakraborty, Nabarun; Meyerhoff, James] Geneva Fdn, Tacoma, WA USA. [Hammamieh, Rasha; Jett, Marti] US Army, Integrat Syst Biol Program, Ctr Environm Hlth Res, Ft Detrick, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 EI 1530-6860 J9 FASEB J JI Faseb J. PD APR PY 2015 VL 29 SU 1 MA 888.13 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA CS0BT UT WOS:000361722705074 ER PT J AU Paez, R Romero, M Dobyns, A Francis, M Taylor, M Longo, L Wilson, C Wilson, S AF Paez, Ricardo Romero, Monica Dobyns, Abby Francis, Michael Taylor, Mark Longo, Lawrence Wilson, Christopher Wilson, Sean TI Influence of Maturation on Ca2+ Waveform Modulation by c-AMP and c-GMP in Pulmonary Arterial Smooth Muscle of Sheep SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology Meeting CY MAR 28-APR 01, 2015 CL Boston, MA SP Amer Assoc Anatomists, Amer Physiol Soc, Amer Soc Biochem & Mol Biol, ASIP, ASN, ASPET C1 [Paez, Ricardo; Dobyns, Abby; Longo, Lawrence; Wilson, Christopher; Wilson, Sean] Loma Linda Univ, Sch Med, Ctr Perinatal Biol, Loma Linda, CA USA. [Romero, Monica; Wilson, Sean] LLUSOM, Adv Imaging & Microscopy Core, Loma Linda, CA USA. [Francis, Michael; Taylor, Mark] USA, Coll Med, Physiol, Mobile, AL USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 EI 1530-6860 J9 FASEB J JI Faseb J. PD APR PY 2015 VL 29 SU 1 MA 1031.11 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA CS0BT UT WOS:000361722707457 ER PT J AU Pasiakos, S McClung, H Murphy, N Margolis, L Lin, G Hydren, J Davis, B Young, A AF Pasiakos, Stefan McClung, Holly Murphy, Nancy Margolis, Lee Lin, Gregory Hydren, Jay Davis, Betty Young, Andrew TI Muscle Protein Synthetic Responses to Essential Amino Acid Supplementation during Load Carriage Exercise SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology Meeting CY MAR 28-APR 01, 2015 CL Boston, MA SP Amer Assoc Anatomists, Amer Physiol Soc, Amer Soc Biochem & Mol Biol, ASIP, ASN, ASPET C1 [Pasiakos, Stefan; McClung, Holly; Murphy, Nancy; Margolis, Lee; Lin, Gregory; Hydren, Jay; Young, Andrew] US Army Res Inst Environm Med, Mil Nutr Div, Natick, MA USA. [Davis, Betty] US Army Natick Soldier Res Dev & Engn Ctr, Combat Feeding Directorate, Natick, MA USA. RI Hydren, Jay/H-3654-2016 OI Hydren, Jay/0000-0001-9385-8898 NR 0 TC 0 Z9 0 U1 1 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 EI 1530-6860 J9 FASEB J JI Faseb J. PD APR PY 2015 VL 29 SU 1 MA 742.3 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA CS0BT UT WOS:000361722702132 ER PT J AU Pierce, L Kurata, W Matsumoto, K Farmer, D Clark, M AF Pierce, Lisa Kurata, Wendy Matsumoto, Karen Farmer, Douglas Clark, Margaret TI Alterations in Global DNA Methylation/Hydroxymethylation and MicroRNA Expression in a Rat Model of Gulf War Illness SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology Meeting CY MAR 28-APR 01, 2015 CL Boston, MA SP Amer Assoc Anatomists, Amer Physiol Soc, Amer Soc Biochem & Mol Biol, ASIP, ASN, ASPET C1 [Pierce, Lisa; Kurata, Wendy; Matsumoto, Karen; Farmer, Douglas; Clark, Margaret] Tripler Army Med Ctr, Clin Invest, Honolulu, HI 96859 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 EI 1530-6860 J9 FASEB J JI Faseb J. PD APR PY 2015 VL 29 SU 1 MA 814.6 PG 2 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA CS0BT UT WOS:000361722703217 ER PT J AU Quinn, C Audet, G Charkoudian, N Leon, L AF Quinn, Carrie Audet, Gerald Charkoudian, Nisha Leon, Lisa TI Cardiovascular Dysregulation during Heat Stroke Recovery in Rats SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Quinn, Carrie; Audet, Gerald; Charkoudian, Nisha; Leon, Lisa] US Army Res Inst Environm Med, Thermal & Mt Med, Natick, MA USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 EI 1530-6860 J9 FASEB J JI Faseb J. PD APR PY 2015 VL 29 SU 1 MA 993.9 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA CS0BT UT WOS:000361722707216 ER PT J AU Smith, T Wilson, M Young, A Montain, S AF Smith, Tracey Wilson, Marques Young, Andrew Montain, Scott TI Sleep Restriction Delays Suction Blister Skin Barrier Restoration SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology Meeting CY MAR 28-APR 01, 2015 CL Boston, MA SP Amer Assoc Anatomists, Amer Physiol Soc, Amer Soc Biochem & Mol Biol, ASIP, ASN, ASPET C1 [Smith, Tracey; Wilson, Marques; Young, Andrew; Montain, Scott] US Army Res Inst Environm Med, Mil Nutr Div, Natick, MA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 EI 1530-6860 J9 FASEB J JI Faseb J. PD APR PY 2015 VL 29 SU 1 MA 1037.4 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA CS0BT UT WOS:000361722708009 ER PT J AU Srinivasan, S Shupp, J Donohue, D Hamilton, B Moffatt, L Hammamieh, R Jett, M AF Srinivasan, Seshamalini Shupp, Jeffrey Donohue, Duncan Hamilton, Brittany Moffatt, Lauren Hammamieh, Rasha Jett, Marti TI Time-course Characterization of Burn-Induced Coagulopathy using a Systems Biology Approach SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology Meeting CY MAR 28-APR 01, 2015 CL Boston, MA SP Amer Assoc Anatomists, Amer Physiol Soc, Amer Soc Biochem & Mol Biol, ASIP, ASN, ASPET C1 [Srinivasan, Seshamalini; Donohue, Duncan] Geneva Fdn, Integrat Syst Biol, Tacoma, WA 98402 USA. [Shupp, Jeffrey] Washington Hosp Ctr, Dept Surg, Burn Ctr, MedStar, Washington, DC 20010 USA. [Shupp, Jeffrey; Hamilton, Brittany; Moffatt, Lauren] MedStar Hlth Res Inst, Firefighters Burn & Surg Res Lab, Washington, DC 20010 USA. [Hammamieh, Rasha; Jett, Marti] US Army, Ctr Environm Hlth Res, Integrat Syst Biol, Ft Detrick, MD 21702 USA. NR 0 TC 0 Z9 0 U1 2 U2 2 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 EI 1530-6860 J9 FASEB J JI Faseb J. PD APR PY 2015 VL 29 SU 1 MA 884.61 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA CS0BT UT WOS:000361722704474 ER PT J AU Torres, L Salgado, C Valdez, C Sondeen, J Dubick, M Torres, I AF Torres, Luciana Salgado, Christi Valdez, Celina Sondeen, Jill Dubick, Michael Torres Filho, Ivo TI Protective Function of Endothelial Glycocalyx (EG) during Hemorrhagic Shock (HS) in Skeletal Muscle: Integration of Systemic and Local Parameters In Vivo SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology Meeting CY MAR 28-APR 01, 2015 CL Boston, MA SP Amer Assoc Anatomists, Amer Physiol Soc, Amer Soc Biochem & Mol Biol, ASIP, ASN, ASPET C1 [Torres, Luciana; Salgado, Christi; Valdez, Celina; Sondeen, Jill; Dubick, Michael; Torres Filho, Ivo] US Army Inst Surg Res, Damage Control Resuscitat, Sam Houston, TX USA. NR 0 TC 1 Z9 1 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 EI 1530-6860 J9 FASEB J JI Faseb J. PD APR PY 2015 VL 29 SU 1 MA 800.9 PG 2 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA CS0BT UT WOS:000361722703045 ER PT J AU Uyehara, C Wetstein, P Ichimura, W Murata, LA Sato, A Hernandez, C Kajiura, L AF Uyehara, Catherine Wetstein, Paul Ichimura, Wayne Murata, Lee-Ann Sato, Aileen Hernandez, Claudia Kajiura, Lauren TI Vasopressin Increases Adrenal Blood Flow in a Pig Model of Hemorrhagic Shock SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology Meeting CY MAR 28-APR 01, 2015 CL Boston, MA SP Amer Assoc Anatomists, Amer Physiol Soc, Amer Soc Biochem & Mol Biol, ASIP, ASN, ASPET C1 [Uyehara, Catherine; Ichimura, Wayne; Murata, Lee-Ann; Sato, Aileen; Hernandez, Claudia; Kajiura, Lauren] Tripler Army Med Ctr, Dept Clin Invest, Honolulu, HI 96859 USA. [Wetstein, Paul] Tripler Army Med Ctr, Dept Surg, Honolulu, HI 96859 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 EI 1530-6860 J9 FASEB J JI Faseb J. PD APR PY 2015 VL 29 SU 1 MA 968.15 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA CS0BT UT WOS:000361722706462 ER PT J AU Wentz, L Berry-Caban, C Eldred, J Wu, Q AF Wentz, Laurel Berry-Caban, Cristobal Eldred, Jerad Wu, Qiang TI Vitamin D Correlation with Testosterone Concentration in US Army Special Operations Personnel SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology Meeting CY MAR 28-APR 01, 2015 CL Boston, MA SP Amer Assoc Anatomists, Amer Physiol Soc, Amer Soc Biochem & Mol Biol, ASIP, ASN, ASPET C1 [Wentz, Laurel; Wu, Qiang] E Carolina Univ, Nutr Sci, Greenville, NC USA. [Berry-Caban, Cristobal; Eldred, Jerad] Womack Army Med Ctr, Dept Clin Invest, Ft Bragg, NC USA. NR 0 TC 1 Z9 1 U1 1 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 EI 1530-6860 J9 FASEB J JI Faseb J. PD APR PY 2015 VL 29 SU 1 MA 733.5 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA CS0BT UT WOS:000361722702008 ER PT J AU Agarwal, S Lieberman, H Fulgoni, V AF Agarwal, Sanjiv Lieberman, Harris Fulgoni, Victor TI Effects of Moderate Alcohol Intake on Markers of Liver Function in a Large Representative Sample of the US Population SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Agarwal, Sanjiv] Nutr NutriSci LLC, East Norriton, PA USA. [Agarwal, Sanjiv; Fulgoni, Victor] ORISE Oak Ridge Inst Sci & Educ, Belcamp, MD USA. [Lieberman, Harris] US Army, Environm Med Res Inst, Mil Nutr Div, Natick, MA USA. [Fulgoni, Victor] Nutr Nutr Impact LLC, Battle Creek, MI USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 EI 1530-6860 J9 FASEB J JI Faseb J. PD APR PY 2015 VL 29 SU 1 MA LB299 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA CR6PV UT WOS:000361470500297 ER PT J AU Bukhari, A Das, SK Montain, S McGraw, S Lutz, L Sepowitz, J Niro, P Young, A Roberts, S AF Bukhari, Asma Das, Sai Krupa Montain, Scott McGraw, Susan Lutz, Laura Sepowitz, John Niro, Philip Young, Andrew Roberts, Susan TI Weight Control Practices in Civilian Dependents of Active Duty Military Personnel SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Bukhari, Asma; Montain, Scott; McGraw, Susan; Lutz, Laura; Sepowitz, John; Niro, Philip; Young, Andrew; Roberts, Susan] US Army Res Inst Environm Med, MND, Natick, MA USA. [Das, Sai Krupa] Tufts Univ, USDA, Energy Metab Lab, JM,HNRCA, Boston, MA 02111 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 EI 1530-6860 J9 FASEB J JI Faseb J. PD APR PY 2015 VL 29 SU 1 MA 595.1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA CR6PV UT WOS:000361470505061 ER PT J AU Darlington, D Wu, XW Cap, A AF Darlington, Daniel Wu, Xiaowu Cap, Andrew TI Coagulopathy after Polytrauma and Hemorrhage in Rats SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Darlington, Daniel; Wu, Xiaowu; Cap, Andrew] US Army Inst Surg Res, Blood Program, San Antonio, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 EI 1530-6860 J9 FASEB J JI Faseb J. PD APR PY 2015 VL 29 SU 1 MA 641.7 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA CR6PV UT WOS:000361470505428 ER PT J AU Donohue, D Gautam, A Ann-Miller, S Hammamieh, R Jett, M AF Donohue, Duncan Gautam, Aarti Ann-Miller, Stacy Hammamieh, Rasha Jett, Marti TI Identifying and Correcting RNA Preservation Differences in Human Blood Samples SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Donohue, Duncan; Gautam, Aarti; Ann-Miller, Stacy] Geneva Fdn, USACEHR, Tacoma, WA USA. [Donohue, Duncan; Gautam, Aarti; Ann-Miller, Stacy; Hammamieh, Rasha; Jett, Marti] USACEHR, US Army Med Res & Mat Command, Integrat Syst Biol, Ft Detrick, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 EI 1530-6860 J9 FASEB J JI Faseb J. PD APR PY 2015 VL 29 SU 1 MA 562.20 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA CR6PV UT WOS:000361470503478 ER PT J AU Fulco, C Dineen, S Audet, G Leon, L AF Fulco, Cameron Dineen, Shauna Audet, Gerald Leon, Lisa TI Cerebellar HSP70 Remains Elevated During Heat Stroke Recovery despite Return to Baseline Core Temperature SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Fulco, Cameron; Dineen, Shauna; Audet, Gerald; Leon, Lisa] US Army Res Inst Environm Med, Thermal Mt Med Div, Natick, MA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 EI 1530-6860 J9 FASEB J JI Faseb J. PD APR PY 2015 VL 29 SU 1 MA LB673 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA CR6PV UT WOS:000361470501094 ER PT J AU Gaffney-Stomberg, E Lutz, L Rood, J Cable, S Hughes, J Pasiakos, S Young, A McClung, J AF Gaffney-Stomberg, Erin Lutz, Laura Rood, Jennifer Cable, Sonya Hughes, Julie Pasiakos, Stefan Young, Andrew McClung, James TI Hemoglobin is Positively Associated with Bone Strength in Young Adults Entering the Military SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Gaffney-Stomberg, Erin; Lutz, Laura; Hughes, Julie; Pasiakos, Stefan; Young, Andrew; McClung, James] US Army, Environm Med Res Inst, MND MPD, Natick, MA 01760 USA. [Rood, Jennifer] Pennington Biomed Res Ctr, Baton Rouge, LA 70808 USA. [Cable, Sonya] Initial Mil Training Ctr Excellence, Ft Eustis, VA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 EI 1530-6860 J9 FASEB J JI Faseb J. PD APR PY 2015 VL 29 SU 1 MA 263.4 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA CR6PV UT WOS:000361470502231 ER PT J AU Kirkpatrick, M Sweeney, R Kasten, S Ditargiani, R Cerasoli, D Otto, T AF Kirkpatrick, Melanie Sweeney, Richard Kasten, Shane Ditargiani, Robert Cerasoli, Douglas Otto, Tamara TI Use of V-Agent Analogs to Probe the Active Site of Atypical Butyrylcholinesterase from Oryzias latipes SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Kirkpatrick, Melanie; Sweeney, Richard; Kasten, Shane; Ditargiani, Robert; Cerasoli, Douglas; Otto, Tamara] US Army, Med Res Inst Chem Def, Res Div, Aberdeen Proving Ground, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 EI 1530-6860 J9 FASEB J JI Faseb J. PD APR PY 2015 VL 29 SU 1 MA 573.6 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA CR6PV UT WOS:000361470504206 ER PT J AU Lieberman, H Marriott, B Judelson, D Glickman, E Geiselman, P Giles, G Mahoney, C AF Lieberman, Harris Marriott, Bernadette Judelson, Daniel Glickman, Ellen Geiselman, Paula Giles, Grace Mahoney, Caroline TI Intake of Caffeine from All Sources Including Energy Drinks and Reasons for Use in US College Students SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Lieberman, Harris] US Army Res Inst Environm Med, Mil Nutr Div, Natick, MA USA. [Marriott, Bernadette] Med Univ S Carolina, Dept Med, Charleston, SC 29425 USA. [Judelson, Daniel] Calif State Univ Fullerton, Dept Kinesiol, Fullerton, CA 92634 USA. [Glickman, Ellen] Kent State Univ, Dept Exercise Physiol, Kent, OH 44242 USA. [Geiselman, Paula] Louisiana State Univ, Pennington Biomed Res Ctr, Dept Psychol, Baton Rouge, LA 70808 USA. [Giles, Grace; Mahoney, Caroline] US Army Natick Soldier RD&E Ctr, Cognit Sci, Natick, MA USA. NR 0 TC 1 Z9 1 U1 2 U2 10 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 EI 1530-6860 J9 FASEB J JI Faseb J. PD APR PY 2015 VL 29 SU 1 MA 392.1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA CR6PV UT WOS:000361470503019 ER PT J AU Martini, W Rodriguez, C Richardson, J Cap, A Dubick, M AF Martini, Wenjun Rodriguez, Cassandra Richardson, Jonathan Cap, Andrew Dubick, Michael TI In Vivo Effects of Platelet Apheresis on Oxygen Metabolism in Pigs SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Martini, Wenjun; Rodriguez, Cassandra; Richardson, Jonathan; Cap, Andrew; Dubick, Michael] US Army Inst Surg Res, Damage Control Dept, Ft Sam Houston, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 EI 1530-6860 J9 FASEB J JI Faseb J. PD APR PY 2015 VL 29 SU 1 MA 641.1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA CR6PV UT WOS:000361470505422 ER PT J AU McClung, J Gaffney-Stomberg, E Lutz, L Rood, J Cable, S Pasiakos, S Young, A AF McClung, James Gaffney-Stomberg, Erin Lutz, Laura Rood, Jennifer Cable, Sonya Pasiakos, Stefan Young, Andrew TI Calcium and Vitamin D Supplementation Does Not Affect Iron Status during Initial Military Training: A Randomized, Double-Blind, Placebo-Controlled Trial SO FASEB JOURNAL LA English DT Meeting Abstract C1 [McClung, James; Gaffney-Stomberg, Erin; Lutz, Laura; Pasiakos, Stefan; Young, Andrew] US Army, Environm Med Res Inst, Mil Nutr Div, Natick, MA 01760 USA. [Rood, Jennifer] Pennington Biomed Res Ctr, Baton Rouge, LA 70808 USA. [Cable, Sonya] Initial Mil Training Ctr Excellence, Ft Eustis, VA USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 EI 1530-6860 J9 FASEB J JI Faseb J. PD APR PY 2015 VL 29 SU 1 MA 263.1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA CR6PV UT WOS:000361470502228 ER PT J AU Montain, S Johannsen, N Champagne, C Marriott, B Hibbeln, J Hawes, M Berry, K AF Montain, Scott Johannsen, Neil Champagne, Catherine Marriott, Bernadette Hibbeln, Joseph Hawes, Michael Berry, Kevin TI Influence of Omega-6 HUFA Status on Recovery of Muscle Performance After Fatiguing Exercise SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Montain, Scott] US Army, Inst Environm Med, Mil Nutr, Natick, MA 01760 USA. [Johannsen, Neil; Champagne, Catherine] Pennington Biomed Res Ctr, Dept Nutr, Baton Rouge, LA 70808 USA. [Marriott, Bernadette] Med Univ S Carolina, Dept Med, Charleston, SC 29425 USA. [Hibbeln, Joseph] NIAAA, Nutr Neurosci, NIH, Silver Spring, MD USA. [Hawes, Michael] Owner Belovo Inc, Pinehurst, NC USA. [Berry, Kevin] Samueli Inst, Mil Med Res, Alexandria, VA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 EI 1530-6860 J9 FASEB J JI Faseb J. PD APR PY 2015 VL 29 SU 1 MA 598.6 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA CR6PV UT WOS:000361470505127 ER PT J AU Morris, R Schaffer, B Lundy, J Pidcoke, H Cap, A Schwacha, M AF Morris, Rachel Schaffer, Beverly Lundy, John Pidcoke, Heather Cap, Andrew Schwacha, Martin TI Interrelationships Between Platelet Activity and the Immunoinflammatory Response to Severe Injury SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Schaffer, Beverly; Lundy, John; Pidcoke, Heather; Cap, Andrew; Schwacha, Martin] US Army Inst Surg Res, Blood Res, Jbsa Ft Sam Houston, TX USA. [Morris, Rachel; Pidcoke, Heather; Cap, Andrew; Schwacha, Martin] Univ Texas Hlth Sci Ctr San Antonio, Surg, San Antonio, TX 78229 USA. NR 0 TC 0 Z9 0 U1 2 U2 2 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 EI 1530-6860 J9 FASEB J JI Faseb J. PD APR PY 2015 VL 29 SU 1 MA 641.2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA CR6PV UT WOS:000361470505423 ER PT J AU O'Connor, K Lieberman, H Young, A Montain, S Scisco, J Karl, J AF O'Connor, Kristie Lieberman, Harris Young, Andrew Montain, Scott Scisco, Jenna Karl, J. TI Altered Gut Hormone Secretion Precedes Overeating Following Acute Energy Deprivation SO FASEB JOURNAL LA English DT Meeting Abstract C1 [O'Connor, Kristie; Lieberman, Harris; Young, Andrew; Montain, Scott; Scisco, Jenna; Karl, J.] US Army Res Inst Environm Med, MND, Natick, MA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 EI 1530-6860 J9 FASEB J JI Faseb J. PD APR PY 2015 VL 29 SU 1 MA 594.2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA CR6PV UT WOS:000361470505049 ER PT J AU Shen, C Romero, M Brunelle, A Dobyns, A Francis, M Taylor, M Longo, L Wilson, C Wilson, S AF Shen, Christine Romero, Monica Brunelle, Alexander Dobyns, Abigail Francis, Michael Taylor, Mark Longo, Lawrence Wilson, Christopher Wilson, Sean TI Activation Of L-type Calcium Channels Influences Calcium Waves After Long-Term Hypoxia And Developmental Maturation SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Shen, Christine; Brunelle, Alexander; Dobyns, Abigail; Longo, Lawrence; Wilson, Christopher; Wilson, Sean] Loma Linda Univ, Sch Med, Ctr Perinatal Biol, Loma Linda, CA 92350 USA. [Francis, Michael; Taylor, Mark] USA, Coll Med, Physiol, Washington, DC USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 EI 1530-6860 J9 FASEB J JI Faseb J. PD APR PY 2015 VL 29 SU 1 MA 662.1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA CR6PV UT WOS:000361470506128 ER PT J AU Smith, S Gregory, J Zeisel, S Ueland, P Gibson, C Mader, T Kinchen, J Ploutz-Snyder, R Zwart, S AF Smith, Scott Gregory, Jesse Zeisel, Steven Ueland, Per Gibson, C. Mader, Thomas Kinchen, Jason Ploutz-Snyder, Robert Zwart, Sara TI Vision Issues and Space Flight: Evaluation of One-Carbon Metabolism Polymorphisms SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Smith, Scott] NASA, Biomed Res Environ Sci Div, Houston, TX USA. [Gregory, Jesse] UF, Gainesville, FL USA. [Zeisel, Steven] UNC, Chapel Hill, NC USA. [Ueland, Per] Univ Bergen, N-5020 Bergen, Norway. [Mader, Thomas] US Army, Washington, DC USA. [Kinchen, Jason] Metabolon, Durham, NC USA. NR 0 TC 0 Z9 0 U1 1 U2 3 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 EI 1530-6860 J9 FASEB J JI Faseb J. PD APR PY 2015 VL 29 SU 1 MA 134.1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA CR6PV UT WOS:000361470501477 ER PT J AU Wu, XW Schwacha, M Dubick, M Cap, A Darlington, D AF Wu, Xiaowu Schwacha, Martin Dubick, Michael Cap, Andrew Darlington, Daniel TI Severe Polytrauma Leads to Acute Lung Injury in Rats SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Wu, Xiaowu; Schwacha, Martin; Dubick, Michael; Cap, Andrew; Darlington, Daniel] US Army Inst Surg Res, Blood Program, San Antonio, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 EI 1530-6860 J9 FASEB J JI Faseb J. PD APR PY 2015 VL 29 SU 1 MA 641.8 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA CR6PV UT WOS:000361470505429 ER PT J AU Stratton, A Fenderson, J Kenny, P Helman, DL AF Stratton, Amy Fenderson, Joshua Kenny, Patrick Helman, Donald Lee TI Severe acute hepatitis following intravenous amiodarone : a case report and review of the literature SO ACTA GASTRO-ENTEROLOGICA BELGICA LA English DT Article DE amiodarone hepatotoxicity; polysorbate 80; amiodarone hepatitis; severe acute hepatitis ID PARENTERAL AMIODARONE; ISCHEMIC HEPATITIS; CAUSALITY ASSESSMENT; ADVERSE REACTIONS; HEPATOTOXICITY; DRUGS AB Background and Aims : Hepatotoxic complications of long-term oral amiodarone therapy have been well described; however, liver injury secondary to parenteral infusion of amiodarone is uncommon, potentially fatal, and poorly understood. The hepatotoxicity is thought to result from the diluent polysorbate 80 and not the amiodarone its self. Theories suggest an allergic or immunologic response leading to alterations in the hepatocellular membrane while some propose that ischemia, not a drug reaction, is truly to blame. Methods : Both the PubMed and Embase databases were searched for cases of acute hepatitis implicating intravenous amiodarone with a total of 25 cases from 1986 to 2012 identified. Each case was then carefully evaluated to determine the connection between parenteral amiodarone and acute hepatotoxicity while assessing for evidence of potential ischemia. Results : Of the 25 published cases of amiodarone induced acute hepatotoxicity available for review, only 10 provide evidence to conclusively implicate parenteral amiodarone as the etiology. We add the eleventh reported case of parenteral amiodarone induced acute severe hepatitis to the literature and report the most comprehensive review of this topic to date. Conclusion : There is sufficient evidence to support amiodarone induced acute hepatotoxicity as a unique entity separate from ischemic hepatitis. If suspected, parenteral amiodarone should be discontinued and held indefinitely. C1 [Stratton, Amy; Fenderson, Joshua; Kenny, Patrick; Helman, Donald Lee] Tripler Army Med Ctr, Dept Internal Med, Honolulu, HI 96859 USA. [Kenny, Patrick] Tripler Army Med Ctr, Gastroenterol Serv, Honolulu, HI 96859 USA. [Helman, Donald Lee] Tripler Army Med Ctr, Crit Care & Pulmonol Serv, Honolulu, HI 96859 USA. RP Stratton, A (reprint author), Tripler Army Med Ctr, DO, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM amynstratton@gmail.com NR 29 TC 1 Z9 1 U1 1 U2 3 PU UNIV CATHOLIQUE LOUVAIN-UCL PI BRUSSELS PA CLIN UNIV SAINT LUC, AVE HIPPOCRATE 10, BRUSSELS, B-1200, BELGIUM SN 0001-5644 J9 ACTA GASTRO-ENT BELG JI Acta Gastro-Enterol. Belg. PD APR-JUN PY 2015 VL 78 IS 2 BP 233 EP 239 PG 7 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA CR9EA UT WOS:000361654800007 PM 26151694 ER PT J AU Heston, AH Schwartz, AL Justice-Gardiner, H Hohman, KH AF Heston, Ann-Hilary Schwartz, Anna L. Justice-Gardiner, Haley Hohman, Katherine H. TI Addressing Physical Activity Needs of Survivors by Developing a Community-Based Exercise Program: LIVESTRONG (R) at the YMCA SO CLINICAL JOURNAL OF ONCOLOGY NURSING LA English DT Article DE exercise; physical activity; LIVESTRONG Foundation; YMCA; community health services; cancer survivorship ID CANCER SURVIVORS; GUIDELINES; DIAGNOSIS AB Background: Although methods of cancer detection and treatment have improved, the side effects of treatment can cause profound debilitation that may linger years after treatment ends. Exercise during and after cancer treatment is safe, and it minimizes many of the deleterious physical and emotional side effects. With this evidence in mind, the LIVESTRONG Foundation and the YMCA of the USA collaborated to develop a community-based physical activity program for survivors, LIVESTRONG (R) at the YMCA. Objectives: This article provides in-depth information about the development of the LIVESTRONG at the YMCA program and its subsequent spread to meet the physical activity needs of survivors across the country. Methods: Participating YMCAs engage in regular data collection efforts to track progress on organizational change and program delivery. These efforts include a staff evaluation survey, functional assessment of participants, patient-reported health status assessment, and patient program evaluation. Findings: From the time of its development, the LIVESTRONG at the YMCA program has served more than 29,000 survivors and trained more than 2,200 LIVESTRONG at the YMCA instructors. A national survey of more than 1,600 program participants demonstrates positive outcomes on health and well-being, as well as intent to continue exercising after the program's end. C1 [Heston, Ann-Hilary] USA, YMCA, Chron Dis Prevent Programs, Chicago, IL 60606 USA. [Schwartz, Anna L.] No Arizona Univ, Sch Nursing, Flagstaff, AZ 86011 USA. [Justice-Gardiner, Haley] March Dimes Texas Chapter, Program Serv, Austin, TX USA. [Hohman, Katherine H.] USA, YMCA, Qual Improvement, Chicago, IL USA. RP Heston, AH (reprint author), USA, YMCA, Chron Dis Prevent Programs, Chicago, IL 60606 USA. EM ann-hilary.heston@ymca.net NR 16 TC 2 Z9 2 U1 0 U2 2 PU ONCOLOGY NURSING SOC PI PITTSBURGH PA 125 ENTERPRISE DR, PITTSBURGH, PA 15275 USA SN 1092-1095 EI 1538-067X J9 CLIN J ONCOL NURS JI Clin. J. Oncol. Nurs. PD APR PY 2015 VL 19 IS 2 BP 213 EP 217 DI 10.1188/15.CJON.213-217 PG 5 WC Oncology; Nursing SC Oncology; Nursing GA CF3LI UT WOS:000352449700019 PM 25840387 ER PT J AU Wu, J Yu, P Susha, AS Sablon, KA Chen, HY Zhou, ZH Li, HD Ji, HN Niu, XB Govorov, AO Rogach, AL Wang, ZMM AF Wu, Jiang Yu, Peng Susha, Andrei S. Sablon, Kimberly A. Chen, Haiyuan Zhou, Zhihua Li, Handong Ji, Haining Niu, Xiaobin Govorov, Alexander O. Rogach, Andrey L. Wang, Zhiming M. TI Broadband efficiency enhancement in quantum dot solar cells coupled with multispiked plasmonic nanostars SO NANO ENERGY LA English DT Article DE Surface plasmon; Nanoparticles; Noble metals; Solar cells; Quantum dots ID GOLD NANOPARTICLES; OPTICAL-PROPERTIES; AG; TRANSITIONS; GRAPHENE; SIZE AB We report a significant broadband enhancement of the external quantum efficiency of the quantum dot solar cell by coupling with plasmonic nanostars via a simple and scalable "boiling deposition" technique. The multispiked nanostars provide broadband scattering and absorption cross-sections, which can be engineered to dramatically boost the performance of the solar cells. The localized near field modes of nanostars result in an external quantum efficiency enhancement over 400% for short-wavelength light absorbed in the emitter, while plasmon light scattering causes distinct improvement in quantum efficiency (10-50%) in the long-wavelength region up to 1100 nm. Finite difference time domain method is adopted to explain the origin of the optical absorption enhancement in the quantum dot solar cells. The broadband light concentration by plasmonic nanostars can significantly reduce the amount of quantum dot materials required for a solar cell and provide efficient utilization of the full solar spectrum. (C) 2015 Elsevier Ltd. All rights reserved. C1 [Wu, Jiang; Yu, Peng; Chen, Haiyuan; Zhou, Zhihua; Li, Handong; Ji, Haining; Niu, Xiaobin; Wang, Zhiming M.] Univ Elect Sci & Technol China, Inst Fundamental & Frontier Sci, Chengdu 610054, Peoples R China. [Wu, Jiang; Zhou, Zhihua; Li, Handong; Ji, Haining; Niu, Xiaobin; Wang, Zhiming M.] Univ Elect Sci & Technol China, State Key Lab Elect Thin Films & Integrated Devic, Chengdu 610054, Peoples R China. [Wu, Jiang] UCL, Dept Elect & Elect Engn, London WC1E 7JE, England. [Susha, Andrei S.; Rogach, Andrey L.] City Univ Hong Kong, Dept Phys & Mat Sci, Hong Kong, Hong Kong, Peoples R China. [Sablon, Kimberly A.] US Army, Res Lab, Adelphi, MD 20783 USA. [Govorov, Alexander O.] Ohio Univ, Dept Phys & Astron, Athens, OH 45701 USA. RP Wang, ZMM (reprint author), Univ Elect Sci & Technol China, Inst Fundamental & Frontier Sci, Chengdu 610054, Peoples R China. EM zhmwang@uestc.edu.cn RI Wang, Zhiming/Q-1031-2015; Li, Handong/J-5225-2015; Zhou, Zhihua/B-7290-2009 OI Zhou, Zhihua/0000-0001-5014-6946 FU Specialized Research Fund for the Doctoral Program of Higher Education (SRFDP); Research Grants Council Earmarked Research Grants (RGC-ERG) [M_CityU 102/12]; National Natural Science Foundation of China [NSFC-61474015]; Fundamental Research Funds for Central Universities [ZYGX2012J034] FX J. Wu and P. Yu contributed equally to this work. This work was supported by the Specialized Research Fund for the Doctoral Program of Higher Education (SRFDP) and Research Grants Council Earmarked Research Grants (RGC-ERG) under the Grant M_CityU 102/12, the National Natural Science Foundation of China through Grant NSFC-61474015, and the Fundamental Research Funds for Central Universities under the Grant ZYGX2012J034. NR 34 TC 21 Z9 21 U1 4 U2 50 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 2211-2855 EI 2211-3282 J9 NANO ENERGY JI Nano Energy PD APR PY 2015 VL 13 BP 827 EP 835 DI 10.1016/j.nanoen.2015.02.012 PG 9 WC Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied SC Chemistry; Science & Technology - Other Topics; Materials Science; Physics GA CN4QI UT WOS:000358414700084 ER PT J AU Netherland, MD Jones, D AF Netherland, Michael D. Jones, Dean TI Fluridone-Resistant Hydrilla (Hydrilla verticillata) Is Still Dominant in the Kissimmee Chain of Lakes, FL SO INVASIVE PLANT SCIENCE AND MANAGEMENT LA English DT Article DE Aquatic herbicide; invasive aquatic plant; submersed aquatic vegetation ID EURASIAN WATERMILFOIL; PHYTOENE DESATURASE; HERBICIDE RESISTANCE; ECOLOGICAL FITNESS; FLORIDA; MANAGEMENT; EVOLUTION; SENSITIVITY; NORFLURAZON; POPULATION AB The invasive aquatic plant hydrilla rapidly spread through the 28,500 ha Kissimmee Chain of Lakes (KCOL) system in Florida in the late 1980s and early 1990s. Large-scale herbicide treatments with fluridone were initiated in 1993 and resulted in widespread reduction in hydrilla; however, by 2000, sustained use of fluridone resulted in dominance of fluridone-resistant strains of hydrilla throughout these lakes. The last large-scale fluridone applications on the KCOL were conducted in 2004, and in 2012, a sampling effort was initiated to determine the status of fluridone-resistant strains of hydrilla given an 8-yr period with no further selection pressure from fluridone. A total of 260 sites were sampled on the lakes during March, May, September, and December 2012. Plants were returned to the lab and exposed to fluridone at concentrations of 5, 10, and 20 mu g L-1 and a pulse-amplitude-modulated (PAM) fluorometer was utilized to measure fluorescence yield of new shoot tissue growth following a 14-d exposure period. Results indicate that 80 to 90% of the sites sampled on the four lakes of the Kissimmee Chain remain resistant to fluridone. Three distinct patterns of response to fluridone were noted, suggesting that susceptible, moderately tolerant, and highly tolerant strains of hydrilla currently coexist on these lakes. Although fluridone-susceptible plants were present on the KCOL, this study clearly demonstrates that most of the hydrilla remained resistant despite an 8-yr period with no fluridone selection pressure. C1 [Netherland, Michael D.] US Army, Engn Res & Dev Ctr, Ctr Aquat & Invas Plants, Gainesville, FL 32653 USA. [Jones, Dean] Univ Florida, Ctr Aquat & Invas Plants, Lake Alfred, FL 33850 USA. RP Netherland, MD (reprint author), US Army, Engn Res & Dev Ctr, Ctr Aquat & Invas Plants, Gainesville, FL 32653 USA. EM mdnether@ufl.edu FU U.S. Army Engineer Aquatic Plant Control Research Program; Environmental Protection Agency, Osceola County Demonstration Project on Hydrilla and Hygrophila in the Upper Kissimmee Chain of Lakes, FL [X796433105]; Florida Fish and Wildlife Commission; Bureau of Invasive Plant Management FX Support and funding for this project was provided by the U.S. Army Engineer Aquatic Plant Control Research Program; the Environmental Protection Agency as part of the Osceola County Demonstration Project on Hydrilla and Hygrophila in the Upper Kissimmee Chain of Lakes, FL. (EPA Grant ID: X796433105); and the Florida Fish and Wildlife Commission, Bureau of Invasive Plant Management. Permission was granted by the Chief of Engineers to publish this research. The authors thank Erin Canter for assistance in field collections and laboratory support. NR 27 TC 1 Z9 1 U1 5 U2 21 PU WEED SCI SOC AMER PI LAWRENCE PA 810 EAST 10TH ST, LAWRENCE, KS 66044-8897 USA SN 1939-7291 EI 1939-747X J9 INVAS PLANT SCI MANA JI Invasive Plant Sci. Manag. PD APR-JUN PY 2015 VL 8 IS 2 BP 212 EP 218 DI 10.1614/IPSM-D-14-00071.1 PG 7 WC Plant Sciences SC Plant Sciences GA CM8HU UT WOS:000357940900011 ER PT J AU Palmqvist, A Baker, L Forbes, VE Gergs, A von der Kammer, F Luoma, S Lutzhoft, HCH Salinas, E Sorensen, M Steevens, J AF Palmqvist, Annemette Baker, Leanne Forbes, Valery E. Gergs, Andre von der Kammer, Frank Luoma, Samuel Lutzhoft, Hans Christian Holten Salinas, Edward Sorensen, Mary Steevens, Jeffery TI NANOMATERIAL ENVIRONMENTAL RISK ASSESSMENT SO INTEGRATED ENVIRONMENTAL ASSESSMENT AND MANAGEMENT LA English DT Editorial Material C1 [Palmqvist, Annemette] Roskilde Univ, Roskilde, Denmark. [Baker, Leanne] Baylor Univ, Waco, TX 76798 USA. [Forbes, Valery E.] Univ Nebraska, Lincoln, NE USA. [Gergs, Andre] Rhein Westfal TH Aachen, Aachen, Germany. [von der Kammer, Frank] Univ Vienna, A-1010 Vienna, Austria. [Luoma, Samuel] Univ Calif Davis, Davis, CA 95616 USA. [Lutzhoft, Hans Christian Holten] Tech Univ Denmark, DK-2800 Lyngby, Denmark. [Salinas, Edward] BASF SE, Ludwigshafen, Germany. [Sorensen, Mary] ENVIRON Int Corp, Atlanta, GA USA. [Steevens, Jeffery] US Army Engineer Res & Dev Ctr, Vicksburg, MS USA. RP Palmqvist, A (reprint author), Roskilde Univ, Roskilde, Denmark. EM apalm@ruc.dk OI Palmqvist, Annemette/0000-0003-3422-0063; Forbes, Valery/0000-0001-9819-9385 NR 0 TC 2 Z9 2 U1 0 U2 10 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1551-3777 EI 1551-3793 J9 INTEGR ENVIRON ASSES JI Integr. Environ. Assess. Manag. PD APR PY 2015 VL 11 IS 2 BP 333 EP 335 DI 10.1002/ieam.1625 PG 3 WC Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA CL5SG UT WOS:000357020200020 PM 25820312 ER PT J AU Lee, BB Baumgartner, I Berlien, P Bianchini, G Burrows, P Gloviczki, P Huang, Y Laredo, J Loose, DA Markovic, J Mattassi, R Parsi, K Rabe, E Rosenblatt, M Shortell, C Stillo, F Vaghi, M Villavicencio, L Zamboni, P AF Lee, B. B. Baumgartner, I. Berlien, P. Bianchini, G. Burrows, P. Gloviczki, P. Huang, Y. Laredo, J. Loose, D. A. Markovic, J. Mattassi, R. Parsi, K. Rabe, E. Rosenblatt, M. Shortell, C. Stillo, F. Vaghi, M. Villavicencio, L. Zamboni, P. TI Diagnosis and Treatment of Venous Malformations Consensus Document of the International Union of Phlebology (IUP): updated 2013 SO INTERNATIONAL ANGIOLOGY LA English DT Article DE Venous malformations; ISSVA Classification; Hamburg classification extratruncular and truncular types; Angiographic classification; Hemolymphatic malformation; Congenital vascular bone syndrome; Marginal vein; Multidisciplinary approach ID CONGENITAL VASCULAR MALFORMATIONS; KLIPPEL-TRENAUNAY-SYNDROME; INFERIOR VENA-CAVA; BUDD-CHIARI-SYNDROME; OF-THE-LITERATURE; ARTERIOVENOUS SHUNTING MALFORMATION; PULMONARY ARTERIAL-HYPERTENSION; SODIUM TETRADECYL SULFATE; KASABACH-MERRITT-SYNDROME; ENDOTHELIAL GROWTH-FACTOR AB Venous malformations (VMs) are the most common vascular developmental anomalies (birth defects). These defects are caused by developmental arrest of the venous system during various stages of embryogenesis. VMs remain a difficult diagnostic and therapeutic challenge due to the wide range of clinical presentations, unpredictable clinical course, erratic response to the. treatment with high recurrence/persistence rates, high morbidity following non-specific conventional treatment, and confusing terminology The Consensus Panel reviewed the recent scientific literature up to the year 2013 to update a previous IUP Consensus (2009) on the same subject. ISSVA Classification with special merits for the differentiation between the congenital vascular malformation (CVM) and vascular tumors was reinforced with an additional review on syndrome-based classification. A "modified" Hamburg classification was adopted to emphasize the importance of extratruncular vs. truncular sub-types of VMs. This incorporated the embryological origin, morphological differences, unique characteristics, prognosis and recurrence rates of VMs based on this embryological classification. The definition and classification of VMs were strengthened with the addition of angiographic data that determines the hemodynamic characteristics, the anatomical pattern of draining veins and hence the risk of complication following sclerotherapy. The hemolymphatic malformations, a combined condition incorporating LMs and other CVMs, were illustrated as a separate topic to differentiate from isolated VMs and to rectify the existing confusion with name-based eponyms such as Klippel-Trenaunay syndrome. Contemporary concepts on VMs were updated with new data including genetic findings linked to the etiology of CVMs and chronic cerebrospinal venous insufficiency. Besides, newly established information on co-agulopathy including the role of D-Dimer was thoroughly reviewed to provide guidelines on investigations and anticoagulation therapy in the management of VMs. Congenital vascular bone syndrome resulting in angio-osteo-hyper/hypotrophy and (lateral) marginal vein was separately reviewed. Background data on arterio-venous malformations was included to differentiate this anomaly from syndrome-based VMs. For the treatment, a new section on laser therapy and also a practical guideline for follow up assessment were added to strengthen the management principle of the multidisciplinary approach. All other therapeutic modalities were thoroughly updated to accommodate a changing concept through the years. C1 [Lee, B. B.; Laredo, J.] George Washington Univ, Sch Med, Surg, Washington, DC 20037 USA. [Lee, B. B.; Laredo, J.] George Washington Univ, Sch Med, Dept Surg, Ctr Vein Lymphat & Vasc Malformat,Div Vasc Surg, Washington, DC 20037 USA. [Markovic, J.; Shortell, C.] Duke Univ, Med Ctr, Div Vasc Surg, Durham, NC USA. [Berlien, P.] Evangel Elisabeth Klin, Laser & Surg, Berlin, Germany. [Berlien, P.] Evangel Elisabeth Klin, Dept Lasermed, Berlin, Germany. [Bianchini, G.; Stillo, F.] IDI Hosp, Div Vasc Surg, Ctr Vasc Anomalies, Rome, Italy. [Burrows, P.] Med Coll Wisconsin, Radiol, Milwaukee, WI 53226 USA. [Burrows, P.] Childrens Hosp Wisconsin, Pediat Vasc Intervent, Milwaukee, WI 53201 USA. [Gloviczki, P.] Mayo Clin, Coll Med, Surg, Rochester, MN USA. [Gloviczki, P.] Mayo Clin, Div Vasc & Endovasc Surg, Rochester, MN USA. [Gloviczki, P.] Mayo Clin, Gonda Vasc Ctr, Rochester, MN USA. [Baumgartner, I.] Univ Hosp Bern, Inselspital, Div Angiol, Swiss Cardiovasc Ctr, Bern, Switzerland. [Loose, D. A.] Die Facharztklin Hamburg, European Ctr Diag & Treatment Vasc Malformat, Dept Angiol & Vasc Surg, Hamburg, Germany. [Mattassi, R.] Clin Inst Humanitas Mater Domini, Vasc Surg, Castellanza, Varese, Italy. [Mattassi, R.] Clin Inst Humanitas Mater Domini, Ctr Vasc Malformat Stefan Belov, Castellanza, Varese, Italy. [Parsi, K.] St Vincents Hosp, Dept Dermatol, Sydney, NSW 2010, Australia. [Parsi, K.] Univ New S Wales, St Vincents Ctr Appl Med Res, Dermatol Phlebol & Fluid Mech Res Program, Sydney, NSW, Australia. [Stillo, F.] IDI Hosp, Vasc Surg, Rome, Italy. [Rabe, E.] Univ Bonn, Dept Dermatol, Dermatol Phlebol & Dermatol Angiol, D-53105 Bonn, Germany. [Rosenblatt, M.] Connecticut Image Guided Surg, Fairfield, CT USA. [Shortell, C.] Duke Univ, Med Ctr, Vasc Residency, Durham, NC USA. [Shortell, C.] Duke Univ, Med Ctr, Dept Surg, Durham, NC 27710 USA. [Vaghi, M.] Hosp G Salvini, Dept Vasc Surg, Garbagnate Milanese, Italy. [Villavicencio, L.] Uniformed Serv Univ Hlth Sci, Dept Surg, Surg, Bethesda, MD 20814 USA. [Villavicencio, L.] Walter Reed Army Med Ctr, Venous & Lymphat Teaching Clin, Bethesda, MD USA. [Huang, Y.] Mayo Clin, Div Vasc & Endovasc Surg, Rochester, MN USA. [Zamboni, P.] Univ Ferrara, Surg, I-44100 Ferrara, Italy. [Zamboni, P.] Univ Ferrara, Vasc Dis Ctr, I-44100 Ferrara, Italy. RP Lee, BB (reprint author), George Washington Univ, Sch Med, Surg, 22nd & I St NW,6th Floor, Washington, DC 20037 USA. NR 368 TC 14 Z9 16 U1 0 U2 5 PU EDIZIONI MINERVA MEDICA PI TURIN PA CORSO BRAMANTE 83-85 INT JOURNALS DEPT., 10126 TURIN, ITALY SN 0392-9590 EI 1827-1839 J9 INT ANGIOL JI Int. Angiol. PD APR PY 2015 VL 34 IS 2 BP 97 EP 149 PG 53 WC Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA CM0FQ UT WOS:000357354200001 PM 24566499 ER PT J AU Heine, HS Hershfield, J Marchand, C Miller, L Halasohoris, S Purcell, BK Worsham, PL AF Heine, Henry S. Hershfield, Jeremy Marchand, Charles Miller, Lynda Halasohoris, Stephanie Purcell, Bret K. Worsham, Patricia L. TI In Vitro Antibiotic Susceptibilities of Yersinia pestis Determined by Broth Microdilution following CLSI Methods SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY LA English DT Article ID ANTIMICROBIAL AGENTS; PLAGUE; RESISTANCE; PLASMIDS AB In vitro susceptibilities to 45 antibiotics were determined for 30 genetically and geographically diverse strains of Yersinia pestis by the broth microdilution method at two temperatures, 28 degrees C and 35 degrees C, following Clinical and Laboratory Standards Institute (CLSI) methods. The Y. pestis strains demonstrated susceptibility to aminoglycosides, quinolones, tetracyclines, beta-lactams, cephalosporins, and carbapenems. Only a 1-well shift was observed for the majority of antibiotics between the two temperatures. Establishing and comparing antibiotic susceptibilities of a diverse but specific set of Y. pestis strains by standardized methods and establishing population ranges and MIC50 and MIC90 values provide reference information for assessing new antibiotic agents and also provide a baseline for use in monitoring any future emergence of resistance. C1 [Heine, Henry S.; Hershfield, Jeremy; Marchand, Charles; Miller, Lynda; Halasohoris, Stephanie; Purcell, Bret K.; Worsham, Patricia L.] US Army Med Res Inst Infect Dis, Bacteriol Div, Ft Detrick, MD USA. RP Heine, HS (reprint author), Univ Florida, Coll Med, Dept Med, Inst Therapeut Innovat, Orlando, FL 32816 USA. EM henry.heine@medicine.ufl.edu FU Defense Threat Reduction Agency [02-4-2C-013] FX The research described herein was sponsored by the Defense Threat Reduction Agency project no. 02-4-2C-013. NR 19 TC 1 Z9 1 U1 0 U2 6 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0066-4804 EI 1098-6596 J9 ANTIMICROB AGENTS CH JI Antimicrob. Agents Chemother. PD APR PY 2015 VL 59 IS 4 BP 1919 EP 1921 DI 10.1128/AAC.04548-14 PG 3 WC Microbiology; Pharmacology & Pharmacy SC Microbiology; Pharmacology & Pharmacy GA CI8BY UT WOS:000354993700012 PM 25583720 ER PT J AU Biron, B Beck, K Dyer, D Mattix, M Twenhafel, N Nalca, A AF Biron, Bethany Beck, Katie Dyer, David Mattix, Marc Twenhafel, Nancy Nalca, Aysegul TI Efficacy of ETI-204 Monoclonal Antibody as an Adjunct Therapy in a New Zealand White Rabbit Partial Survival Model for Inhalational Anthrax SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY LA English DT Article ID PROTECTIVE ANTIGEN; BACILLUS-ANTHRACIS; POSTEXPOSURE PROPHYLAXIS; ANIMAL-MODELS; BIOLOGICAL WEAPON; UNITED-STATES; PATHOLOGY; PATHOGENESIS; INFECTION; TOXIN AB Inhalational anthrax is characterized by extensive bacteremia and toxemia as well as nonspecific to mild flu-like symptoms, until the onset of hypotension, shock, and mortality. Without treatment, the mortality rate approaches 100%. Antibiotic treatment is not always effective, and alternative treatments are needed, such as monotherapy for antibiotic-resistant inhalational anthrax or as an adjunct therapy in combination with antibiotics. The Bacillus anthracis antitoxin monoclonal antibody (MAb) ETI-204 is a high-affinity chimeric deimmunized antibody which targets the anthrax toxin protective antigen (PA). In this study, a partial protection New Zealand White (NZW) rabbit model was used to evaluate the protective efficacy of the adjunct therapy with the MAb. Following detection of PA in the blood, NZW rabbits were administered either an antibiotic (doxycycline) alone or the antibiotic in conjunction with ETI-204. Survival was evaluated to compare the efficacy of the combination adjunct therapy with that of an antibiotic alone in treating inhalational anthrax. Overall, the results from this study indicate that a subtherapeutic regimen consisting of an antibiotic in combination with an anti-PA MAb results in increased survival compared to the antibiotic alone and would provide an effective therapeutic strategy against symptomatic anthrax in nonvaccinated individuals. C1 [Biron, Bethany; Beck, Katie; Dyer, David; Nalca, Aysegul] US Army, Med Res Inst Infect Dis, Ctr Aerobiol Sci, Ft Detrick, MD 21702 USA. [Mattix, Marc; Twenhafel, Nancy] US Army, Med Res Inst Infect Dis, Div Pathol, Ft Detrick, MD 21702 USA. RP Nalca, A (reprint author), US Army, Med Res Inst Infect Dis, Ctr Aerobiol Sci, Ft Detrick, MD 21702 USA. EM aysegul.nalca@us.army.mil FU Office of Biodefense, Research Resources and Translational Research; National Institute of Allergy and Infectious Diseases; USAMRIID FX This study was supported by an interagency agreement between the Office of Biodefense, Research Resources and Translational Research, National Institute of Allergy and Infectious Diseases, and USAMRIID. NR 57 TC 5 Z9 5 U1 1 U2 3 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0066-4804 EI 1098-6596 J9 ANTIMICROB AGENTS CH JI Antimicrob. Agents Chemother. PD APR PY 2015 VL 59 IS 4 BP 2206 EP 2214 DI 10.1128/AAC.04593-14 PG 9 WC Microbiology; Pharmacology & Pharmacy SC Microbiology; Pharmacology & Pharmacy GA CI8BY UT WOS:000354993700046 PM 25645849 ER PT J AU Waag, DM AF Waag, David M. TI Efficacy of Postexposure Therapy against Glanders in Mice SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY LA English DT Article ID BURKHOLDERIA-MALLEI; EXPERIMENTAL MELIOIDOSIS; BALB/C MICE; PSEUDOMALLEI; SUSCEPTIBILITIES; AGENT AB Burkholderia mallei, the causative agent of glanders, is a CDC Tier 1 Select Agent for which there is no preventive vaccine and antibiotic therapy is difficult. In this study, we show that a combination of vaccination using killed cellular vaccine and therapy using moxifloxacin, azithromycin, or sulfamethoxazole-trimethoprim can protect BALB/c mice from lethal infection even when given 5 days after infectious challenge. Vaccination only, or antibiotic therapy only, was not efficacious. Although antibiotics evaluated experimentally can protect when given before or 1 day after challenge, this time course is not realistic in the cases of natural infection or biological attack, when the patient seeks treatment after symptoms develop or after a biological attack has been confirmed and the agent has been identified. Antibiotics can be efficacious after a prolonged interval between exposure and treatment, but only if the animals were previously vaccinated. C1 US Army, Med Res Inst Infect Dis, Bacteriol Div, Ft Detrick, MD 21702 USA. RP Waag, DM (reprint author), US Army, Med Res Inst Infect Dis, Bacteriol Div, Ft Detrick, MD 21702 USA. EM david.m.waag.ctr@mail.mil FU Defense Threat Reduction Agency under USAMRIID project [923678] FX This research was funded by the Defense Threat Reduction Agency under USAMRIID project number 923678. NR 24 TC 0 Z9 0 U1 1 U2 2 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0066-4804 EI 1098-6596 J9 ANTIMICROB AGENTS CH JI Antimicrob. Agents Chemother. PD APR PY 2015 VL 59 IS 4 BP 2236 EP 2241 DI 10.1128/AAC.04801-14 PG 6 WC Microbiology; Pharmacology & Pharmacy SC Microbiology; Pharmacology & Pharmacy GA CI8BY UT WOS:000354993700049 PM 25645854 ER PT J AU Potter, BMJ Xie, LH Vuong, C Zhang, J Zhang, P Duan, DH Luong, TLT Herath, HMTB Nanayakkara, NPD Tekwani, BL Walker, LA Nolan, CK Sciotti, RJ Zottig, VE Smith, PL Paris, RM Read, LT Li, QG Pybus, BS Sousa, JC Reichard, GA Marcsisin, SR AF Potter, Brittney M. J. Xie, Lisa H. Vuong, Chau Zhang, Jing Zhang, Ping Duan, Dehui Luong, Thu-Lan T. Herath, H. M. T. Bandara Nanayakkara, N. P. Dhammika Tekwani, Babu L. Walker, Larry A. Nolan, Christina K. Sciotti, Richard J. Zottig, Victor E. Smith, Philip L. Paris, Robert M. Read, Lisa T. Li, Qigui Pybus, Brandon S. Sousa, Jason C. Reichard, Gregory A. Marcsisin, Sean R. TI Differential CYP 2D6 Metabolism Alters Primaquine Pharmacokinetics SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY LA English DT Article ID ANTIMALARIAL-DRUG PRIMAQUINE; HUMAN CYTOCHROME-P450 2D6; PLASMODIUM-VIVAX MALARIA; GENETIC POLYMORPHISMS; RAT ERYTHROCYTES; 5-HYDROXYPRIMAQUINE; 8-AMINOQUINOLINE; TRANSMISSION; TAFENOQUINE AB Primaquine (PQ) metabolism by the cytochrome P450 (CYP) 2D family of enzymes is required for antimalarial activity in both humans (2D6) and mice (2D). Human CYP 2D6 is highly polymorphic, and decreased CYP 2D6 enzyme activity has been linked to decreased PQ antimalarial activity. Despite the importance of CYP 2D metabolism in PQ efficacy, the exact role that these enzymes play in PQ metabolism and pharmacokinetics has not been extensively studied in vivo. In this study, a series of PQ pharmacokinetic experiments were conducted in mice with differential CYP 2D metabolism characteristics, including wild-type (WT), CYP 2D knockout (KO), and humanized CYP 2D6 (KO/knock-in [KO/KI]) mice. Plasma and liver pharmacokinetic profiles from a single PQ dose (20 mg/kg of body weight) differed significantly among the strains for PQ and carboxy-PQ. Additionally, due to the suspected role of phenolic metabolites in PQ efficacy, these were probed using reference standards. Levels of phenolic metabolites were highest in mice capable of metabolizing CYP 2D6 substrates (WT and KO/KI 2D6 mice). PQ phenolic metabolites were present in different quantities in the two strains, illustrating species-specific differences in PQ metabolism between the human and mouse enzymes. Taking the data together, this report furthers understanding of PQ pharmacokinetics in the context of differential CYP 2D metabolism and has important implications for PQ administration in humans with different levels of CYP 2D6 enzyme activity. C1 [Potter, Brittney M. J.; Xie, Lisa H.; Vuong, Chau; Zhang, Jing; Zhang, Ping; Duan, Dehui; Luong, Thu-Lan T.; Nolan, Christina K.; Sciotti, Richard J.; Zottig, Victor E.; Smith, Philip L.; Paris, Robert M.; Read, Lisa T.; Li, Qigui; Pybus, Brandon S.; Sousa, Jason C.; Reichard, Gregory A.; Marcsisin, Sean R.] Walter Reed Army Inst Res, Div Expt Therapeut, Mil Malaria Res Program, Silver Spring, MD 20910 USA. [Herath, H. M. T. Bandara; Nanayakkara, N. P. Dhammika; Tekwani, Babu L.; Walker, Larry A.] Univ Mississippi, Natl Ctr Nat Prod Res, University, MS 38677 USA. [Tekwani, Babu L.; Walker, Larry A.] Univ Mississippi, Sch Pharm, Dept Pharmacol, University, MS 38677 USA. RP Marcsisin, SR (reprint author), Walter Reed Army Inst Res, Div Expt Therapeut, Mil Malaria Res Program, Silver Spring, MD 20910 USA. EM sean.r.marcsisin.mil@mail.mil FU Joint Warfighter Medical Research Program (JWMRP) [W81XWH1020059, W81XWH1320026]; Military Infectious Diseases Research Program (MIDRP) [Q0302_12_WR_CS] FX This work was supported in part by the Joint Warfighter Medical Research Program (JWMRP), award no. W81XWH1020059 and W81XWH1320026, and the Military Infectious Diseases Research Program (MIDRP), project no. Q0302_12_WR_CS. NR 27 TC 16 Z9 16 U1 3 U2 11 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0066-4804 EI 1098-6596 J9 ANTIMICROB AGENTS CH JI Antimicrob. Agents Chemother. PD APR PY 2015 VL 59 IS 4 BP 2380 EP 2387 DI 10.1128/AAC.00015-15 PG 8 WC Microbiology; Pharmacology & Pharmacy SC Microbiology; Pharmacology & Pharmacy GA CI8BY UT WOS:000354993700066 PM 25645856 ER PT J AU Chamok, NH Anthony, TK Weiss, SJ Ali, M AF Chamok, Nowrin Hasan Anthony, Theodore K. Weiss, Steven J. Ali, Mohammod TI Ultrathin UHF Broadband Antenna on a Nonuniform Aperiodic Metasurface SO IEEE ANTENNAS AND PROPAGATION MAGAZINE LA English DT Article DE Broadband antenna; electromagnetic band gap (EBG); metamaterial; nonuniform aperiodic (NUA) metasurface ID EBG GROUND PLANE; DIPOLE ANTENNA; PATCH ANTENNAS; IMPEDANCE; SURFACES; GAP; SUBSTRATE; BANDWIDTH; DESIGN AB A new concept to design ultrathin directional broadband antennas using a nonuniform aperiodic metasurface is introduced. The study and design of the NUA metasurface show that, by employing a decreasing taper for both the metasurface patch and their interelement spacing, broad impedance and pattern bandwidths can be attained. Experimental results show that, with a total thickness of 0.04 of the free space wavelength (corresponding to the lowest frequency of operation), an octave bandwidth can be attained, which is significantly larger compared with existing designs on uniform mushroom electromagnetic band-gap structures. C1 [Chamok, Nowrin Hasan; Ali, Mohammod] Univ S Carolina, Dept Elect Engn, Columbia, SC 29208 USA. [Anthony, Theodore K.; Weiss, Steven J.] Army Res Lab, Adelphi, MD 20783 USA. RP Chamok, NH (reprint author), Univ S Carolina, Dept Elect Engn, Columbia, SC 29208 USA. EM chamok@email.sc.edu; theodore.k.anthony.civ@mail.mil; steven.j.weiss14.civ@mail.mil; alimo@cec.sc.edu FU Army Research Office (ARO) [W911NF-12-1-0138] FX This work was supported in part by the Army Research Office (ARO) under Grant # W911NF-12-1-0138. NR 50 TC 3 Z9 3 U1 2 U2 14 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1045-9243 EI 1558-4143 J9 IEEE ANTENN PROPAG M JI IEEE Antennas Propag. Mag. PD APR PY 2015 VL 57 IS 2 BP 167 EP 180 DI 10.1109/MAP.2015.2414491 PG 14 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA CI7OG UT WOS:000354952800017 ER PT J AU Boling, MC Nguyen, A Yau, R Cameron, KL Beutler, A Padua, DA Marshall, S AF Boling, M. C. Nguyen, A. Yau, R. Cameron, K. L. Beutler, A. Padua, D. A. Marshall, S. TI MOVEMENT CHARACTERISTICS ASSOCIATED WITH THE DEVELOPMENT OF CHRONIC KNEE PAIN SO OSTEOARTHRITIS AND CARTILAGE LA English DT Meeting Abstract CT World Congress of the Osteoarthritis-Research-Society-International (OARSI) on Osteoarthritis CY APR 30-MAY 03, 2015 CL Seattle, WA SP Osteoarthritis Res Soc Int C1 [Boling, M. C.] Univ N Florida, Jacksonville, FL USA. [Nguyen, A.] High Point Univ, High Point, NC USA. [Yau, R.; Padua, D. A.; Marshall, S.] Univ N Carolina, Chapel Hill, NC USA. [Cameron, K. L.] Keller Army Hosp, West Point, NY USA. [Beutler, A.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1063-4584 EI 1522-9653 J9 OSTEOARTHR CARTILAGE JI Osteoarthritis Cartilage PD APR PY 2015 VL 23 SU 2 MA 62 BP A60 EP A61 PG 2 WC Orthopedics; Rheumatology SC Orthopedics; Rheumatology GA CI8VC UT WOS:000355048800095 ER PT J AU Padua, DA Cameron, KL Beutler, AI de la Motte, SJ Kucera, KL Golightly, YM Marshall, SW AF Padua, D. A. Cameron, K. L. Beutler, A. I. de la Motte, S. J. Kucera, K. L. Golightly, Y. M. Marshall, S. W. TI PROSPECTIVE EVALUATION OF MUSCULOSKELETAL INJURY HISTORY AS PREDICTORS FOR ANTERIOR CRUCIATE LIGAMENT INJURY RISK: THE JUMP-ACL STUDY SO OSTEOARTHRITIS AND CARTILAGE LA English DT Meeting Abstract CT World Congress of the Osteoarthritis-Research-Society-International (OARSI) on Osteoarthritis CY APR 30-MAY 03, 2015 CL Seattle, WA SP Osteoarthritis Res Soc Int C1 [Padua, D. A.; Kucera, K. L.; Golightly, Y. M.; Marshall, S. W.] Univ N Carolina, Chapel Hill, NC USA. [Cameron, K. L.] Keller Army Hosp, West Point, NY USA. [Beutler, A. I.; de la Motte, S. J.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. NR 0 TC 0 Z9 0 U1 0 U2 4 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1063-4584 EI 1522-9653 J9 OSTEOARTHR CARTILAGE JI Osteoarthritis Cartilage PD APR PY 2015 VL 23 SU 2 MA 261 BP A171 EP A172 PG 2 WC Orthopedics; Rheumatology SC Orthopedics; Rheumatology GA CI8VC UT WOS:000355048800291 ER PT J AU Rhee, SY Blanco, JL Jordan, MR Taylor, J Lemey, P Varghese, V Hamers, RL Bertagnolio, S de Wit, TR Aghokeng, AF Albert, J Avi, R Avila-Rios, S Bessong, PO Brooks, JI Boucher, CAB Brumme, ZL Busch, MP Bussmann, H Chaix, ML Chin, BS D'Aquin, TT De Gascun, CF Derache, A Descamps, D Deshpande, AK Djoko, CF Eshleman, SH Fleury, H Frange, P Fujisaki, S Harrigan, PR Hattori, J Holguin, A Hunt, GM Ichimura, H Kaleebu, P Katzenstein, D Kiertiburanakul, S Kim, JH Kim, SS Li, YP Lutsar, I Morris, L Ndembi, N Peng, NGK Paranjape, RS Peeters, M Poljak, M Price, MA Ragonnet-Cronin, ML Reyes-Teran, G Rolland, M Sirivichayakul, S Smith, DM Soares, MA Soriano, VV Ssemwanga, D Stanojevic, M Stefani, MA Sugiura, W Sungkanuparph, S Tanuri, A Tee, KK Truong, HHM van de Vijver, DAMC Vidal, N Yang, CF Yang, RG Yebra, G Ioannidis, JPA Vandamme, AM Shafer, RW AF Rhee, Soo-Yon Blanco, Jose Luis Jordan, Michael R. Taylor, Jonathan Lemey, Philippe Varghese, Vici Hamers, Raph L. Bertagnolio, Silvia de Wit, TobiasF. Rinke Aghokeng, Avelin F. Albert, Jan Avi, Radko Avila-Rios, Santiago Bessong, Pascal O. Brooks, James I. Boucher, Charles A. B. Brumme, Zabrina L. Busch, Michael P. Bussmann, Hermann Chaix, Marie-Laure Chin, Bum Sik D'Aquin, Toni T. De Gascun, Cillian F. Derache, Anne Descamps, Diane Deshpande, Alaka K. Djoko, Cyrille F. Eshleman, Susan H. Fleury, Herve Frange, Pierre Fujisaki, Seiichiro Harrigan, P. Richard Hattori, Junko Holguin, Africa Hunt, Gillian M. Ichimura, Hiroshi Kaleebu, Pontiano Katzenstein, David Kiertiburanakul, Sasisopin Kim, Jerome H. Kim, Sung Soon Li, Yanpeng Lutsar, Irja Morris, Lynn Ndembi, Nicaise Peng, Kee N. G. Paranjape, Ramesh S. Peeters, Martine Poljak, Mario Price, Matt A. Ragonnet-Cronin, Manon L. Reyes-Teran, Gustavo Rolland, Morgane Sirivichayakul, Sunee Smith, Davey M. Soares, Marcelo A. Soriano, Vincent V. Ssemwanga, Deogratius Stanojevic, Maja Stefani, Mariane A. Sugiura, Wataru Sungkanuparph, Somnuek Tanuri, Amilcar Tee, Kok Keng Truong, Hong-Ha M. van de Vijver, David A. M. C. Vidal, Nicole Yang, Chunfu Yang, Rongge Yebra, Gonzalo Ioannidis, John P. A. Vandamme, Anne-Mieke Shafer, Robert W. TI Geographic and Temporal Trends in the Molecular Epidemiology and Genetic Mechanisms of Transmitted HIV-1 Drug Resistance: An Individual-Patient- and Sequence-Level Meta-Analysis SO PLOS MEDICINE LA English DT Article ID RESOURCE-LIMITED SETTINGS; OLIGONUCLEOTIDE LIGATION ASSAY; TREATMENT-NAIVE INDIVIDUALS; SUB-SAHARAN AFRICA; REVERSE-TRANSCRIPTASE; VIROLOGICAL FAILURE; ANTIRETROVIRAL TREATMENT; TREATMENT PROGRAMS; META-REGRESSION; SOUTH-AFRICA AB Background Regional and subtype-specific mutational patterns of HIV-1 transmitted drug resistance (TDR) are essential for informing first-line antiretroviral (ARV) therapy guidelines and designing diagnostic assays for use in regions where standard genotypic resistance testing is not affordable. We sought to understand the molecular epidemiology of TDR and to identify the HIV-1 drug-resistance mutations responsible for TDR in different regions and virus subtypes. Methods and Findings We reviewed all GenBank submissions of HIV-1 reverse transcriptase sequences with or without protease and identified 287 studies published between March 1, 2000, and December 31, 2013, with more than 25 recently or chronically infected ARV-naive individuals. These studies comprised 50,870 individuals from 111 countries. Each set of study sequences was analyzed for phylogenetic clustering and the presence of 93 surveillance drug-resistance mutations (SDRMs). The median overall TDR prevalence in sub-Saharan Africa (SSA), south/southeast Asia (SSEA), upper-income Asian countries, Latin America/Caribbean, Europe, and North America was 2.8%, 2.9%, 5.6%, 7.6%, 9.4%, and 11.5%, respectively. In SSA, there was a yearly 1.09-fold (95% CI: 1.05-1.14) increase in odds of TDR since national ARV scale-up attributable to an increase in non-nucleoside reverse transcriptase inhibitor (NNRTI) resistance. The odds of NNRTI-associated TDR also increased in Latin America/Caribbean (odds ratio [OR] = 1.16; 95% CI: 1.06-1.25), North America (OR = 1.19; 95% CI: 1.12-1.26), Europe (OR = 1.07; 95% CI: 1.01-1.13), and upper-income Asian countries (OR = 1.33; 95% CI: 1.12-1.55). In SSEA, there was no significant change in the odds of TDR since national ARV scale-up (OR = 0.97; 95% CI: 0.92-1.02). An analysis limited to sequences with mixtures at less than 0.5% of their nucleotide positions-a proxy for recent infection-yielded trends comparable to those obtained using the complete dataset. Four NNRTI SDRMs-K101E, K103N, Y181C, and G190A-accounted for > 80% of NNRTI-associated TDR in all regions and subtypes. Sixteen nucleoside reverse transcriptase inhibitor (NRTI) SDRMs accounted for > 69% of NRTI-associated TDR in all regions and subtypes. In SSA and SSEA, 89% of NNRTI SDRMs were associated with high-level resistance to nevirapine or efavirenz, whereas only 27% of NRTI SDRMs were associated with high-level resistance to zidovudine, lamivudine, tenofovir, or abacavir. Of 763 viruses with TDR in SSA and SSEA, 725 (95%) were genetically dissimilar; 38 (5%) formed 19 sequence pairs. Inherent limitations of this study are that some cohorts may not represent the broader regional population and that studies were heterogeneous with respect to duration of infection prior to sampling. Conclusions Most TDR strains in SSA and SSEA arose independently, suggesting that ARV regimens with a high genetic barrier to resistance combined with improved patient adherence may mitigate TDR increases by reducing the generation of new ARV-resistant strains. A small number of NNRTI-resistance mutations were responsible for most cases of high-level resistance, suggesting that inexpensive point-mutation assays to detect these mutations may be useful for pre-therapy screening in regions with high levels of TDR. In the context of a public health approach to ARV therapy, a reliable point-of-care genotypic resistance test could identify which patients should receive standard first-line therapy and which should receive a protease-inhibitor-containing regimen. C1 [Rhee, Soo-Yon; Varghese, Vici; Katzenstein, David; Shafer, Robert W.] Stanford Univ, Dept Med, Stanford, CA 94305 USA. [Blanco, Jose Luis] Univ Barcelona, Hosp Clin Univ, Inst Invest Biomed August Pi & Sunyer, Barcelona, Spain. [Jordan, Michael R.] Tufts Univ, Sch Med, Boston, MA 02111 USA. [Taylor, Jonathan] Stanford Univ, Dept Stat, Stanford, CA 94305 USA. [Lemey, Philippe; Vandamme, Anne-Mieke] Univ Leuven, KU Leuven, Dept Microbiol & Immunol, Rega Inst Med Res Clin & Epidemiol Virol, Leuven, Belgium. [Hamers, Raph L.; de Wit, TobiasF. Rinke] Univ Amsterdam, Acad Med Ctr, Dept Global Hlth & Internal Med, NL-1105 AZ Amsterdam, Netherlands. [Hamers, Raph L.; de Wit, TobiasF. Rinke] Amsterdam Inst Global Hlth & Dev, Amsterdam, Netherlands. [Bertagnolio, Silvia] WHO, CH-1211 Geneva, Switzerland. [Aghokeng, Avelin F.] Virol Lab CREMER IMPM, Yaounde, Cameroon. [Albert, Jan] Karolinska Inst, Dept Microbiol Tumor & Cell Biol, Stockholm, Sweden. [Albert, Jan] Karolinska Univ Hosp, Dept Clin Microbiol, Stockholm, Sweden. [Avi, Radko; Lutsar, Irja] Univ Tartu, Dept Microbiol, EE-50090 Tartu, Estonia. [Avila-Rios, Santiago; Reyes-Teran, Gustavo] Ctr Res Infect Dis, Natl Inst Resp Dis, Mexico City, DF, Mexico. [Bessong, Pascal O.] Univ Venda, Dept Microbiol, HIV AIDS & Global Hlth Res Programme, Thohoyandou, South Africa. [Brooks, James I.] Publ Hlth Agcy Canada, Natl HIV & Retrovirol Labs, Ottawa, ON, Canada. [Boucher, Charles A. B.; van de Vijver, David A. M. C.] Erasmus Univ, Erasmus Med Ctr, Dept Virosci, Rotterdam, Netherlands. [Brumme, Zabrina L.; Harrigan, P. Richard] British Columbia Ctr Excellence HIV AIDS, Vancouver, BC, Canada. [Brumme, Zabrina L.] Simon Fraser Univ, Fac Hlth Sci, Burnaby, BC V5A 1S6, Canada. [Busch, Michael P.] Blood Syst Res Inst, San Francisco, CA USA. [Bussmann, Hermann] Botswana Harvard AIDS Inst Partnership, Gaborone, Botswana. [Chaix, Marie-Laure] Univ Paris Diderot, Hop St Louis, Lab Virol, INSERM,U941, Paris, France. [Chin, Bum Sik] Natl Med Ctr, Ctr Infect Dis, Seoul, South Korea. [D'Aquin, Toni T.] CIRBA Programme PACCI, Abidjan, Cote Ivoire. [De Gascun, Cillian F.] Univ Coll Dublin, UCD Natl Virus Reference Lab, Dublin 2, Ireland. [Derache, Anne] Hop La Pitie Salpetriere, Dept Virol, Paris, France. [Descamps, Diane] Univ Paris Diderot, Hop Bichat Claude Bernard, AP HP, INSERM,UMR 1137,Lab Virol, Paris, France. [Deshpande, Alaka K.] Grant Med Coll, Dept Med, Mumbai, Maharashtra, India. [Deshpande, Alaka K.] Sir Jamshedjee Jeejeebhoy Grp Hosp, Mumbai, Maharashtra, India. [Djoko, Cyrille F.] EMAT CRESAR, Intendance Round About, Global Viral Cameroon, Yaounde, Cameroon. [Eshleman, Susan H.] Johns Hopkins Univ, Sch Med, Dept Pathol, Baltimore, MD 21205 USA. [Fleury, Herve] Univ Bordeaux, Ctr Hosp Univ Bordeaux, CNRS, Lab Virol,UMR 5234, Bordeaux, France. [Frange, Pierre] Hop Necker Enfants Malad, Dept Microbiol, Paris, France. [Fujisaki, Seiichiro] Natl Inst Infect Dis, Influenza Virus Res Ctr, Tokyo, Japan. [Hattori, Junko; Sugiura, Wataru] Nagoya Med Ctr, Natl Hosp Org, Nagoya, Aichi, Japan. [Holguin, Africa; Yebra, Gonzalo] Hosp Univ Ramon y Cajal, Inst Ramon y Cajal Invest Sanitaria, Dept Microbiol, Madrid, Spain. [Hunt, Gillian M.; Morris, Lynn] Natl Inst Communicable Dis, Ctr HIV & STIs, Johannesburg, South Africa. [Ichimura, Hiroshi] Kanazawa Univ, Dept Viral Infect & Int Hlth, Grad Sch Med Sci, Kanazawa, Ishikawa, Japan. [Kaleebu, Pontiano; Ssemwanga, Deogratius] MRC UVRI Uganda Res Unit AIDS, Entebbe, Uganda. [Kiertiburanakul, Sasisopin; Sungkanuparph, Somnuek] Mahidol Univ, Ramathibodi Hosp, Fac Med, Bangkok 10400, Thailand. [Kim, Jerome H.; Rolland, Morgane] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD USA. [Kim, Sung Soon] Korea Natl Inst Hlth, Div Aids, Osong, Chungcheongbuk, South Korea. [Li, Yanpeng; Yang, Rongge] Chinese Acad Sci, Wuhan Inst Virol, State Key Lab Virol, Wuhan, Peoples R China. [Ndembi, Nicaise] Inst Human Virol, Abuja, Nigeria. [Peng, Kee N. G.; Tee, Kok Keng] Univ Malaya, Fac Med, Dept Med, Kuala Lumpur, Malaysia. [Paranjape, Ramesh S.] Indian Council Med Res, Natl AIDS Res Inst, Pune, Maharashtra, India. [Peeters, Martine] INSERM, U1175, UMR 233, Inst Rech Dev, F-34394 Montpellier, France. [Peeters, Martine] Univ Montpellier, F-34394 Montpellier, France. [Peeters, Martine] Computat Biol Inst, Montpellier, France. [Poljak, Mario] Univ Ljubljana, Fac Med, Inst Microbiol, Ljubljana, Slovenia. [Price, Matt A.] Int AIDS Vaccine Initiat, Dept Med Affairs, New York, NY USA. [Price, Matt A.] Univ Calif San Francisco, Sch Med, Dept Epidemiol & Biostat, San Francisco, CA USA. [Ragonnet-Cronin, Manon L.] Univ Edinburgh, Edinburgh, Midlothian, Scotland. [Sirivichayakul, Sunee] Chulalongkorn Univ, Fac Med, Bangkok 10330, Thailand. [Smith, Davey M.] Univ Calif San Diego, La Jolla, CA 92093 USA. [Soares, Marcelo A.; Tanuri, Amilcar] Univ Fed Rio de Janeiro, Rio De Janeiro, Brazil. [Soriano, Vincent V.] Hosp Carlos III, Dept Infect Dis, Madrid, Spain. [Stanojevic, Maja] Univ Belgrade, Inst Microbiol & Immunol, Fac Med, Belgrade, Serbia. [Stefani, Mariane A.] Univ Fed Goias, Goiania, Go, Brazil. [Truong, Hong-Ha M.] Univ Calif San Francisco, Dept Med, San Francisco, CA USA. [Vidal, Nicole] Univ Montpellier I, Inst Rech Dev, Montpellier, France. [Yang, Chunfu] Ctr Dis Control & Prevent, Int Lab Branch, Div Global HIV AIDS, Ctr Global Hlth, Atlanta, GA USA. [Ioannidis, John P. A.] Stanford Univ, Dept Med, Stanford Prevent Res Ctr, Stanford, CA 94305 USA. [Ioannidis, John P. A.] Stanford Univ, Meta Res Innovat Ctr Stanford, Stanford, CA 94305 USA. [Vandamme, Anne-Mieke] Univ Nova Lisboa, Global Hlth & Trop Med, Unidade Microbiol, Inst Higiene Med & Trop, P-1200 Lisbon, Portugal. RP Rhee, SY (reprint author), Stanford Univ, Dept Med, Stanford, CA 94305 USA. EM syrhee@stanford.edu RI lutsar, irja/H-3177-2015; Tee, Kok Keng/A-8148-2008; Vandamme, Anne Mieke/I-4127-2012; OI Tee, Kok Keng/0000-0002-7923-5448; Vandamme, Anne Mieke/0000-0002-6594-2766; , Lynn/0000-0003-3961-7828; Yebra, Gonzalo/0000-0002-3472-3667 FU NIH [R01 AI068581]; Bill & Melinda Gates Foundation grant; CFAR [1P30A142853] FX SYR, VV, and RWS were supported in part from NIH grant R01 AI068581. SYR and RWS were supported in part from an Bill & Melinda Gates Foundation grant. MRJ is supported by CFAR grant 1P30A142853. No funding bodies had any role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 49 TC 49 Z9 51 U1 6 U2 22 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1549-1676 J9 PLOS MED JI PLos Med. PD APR PY 2015 VL 12 IS 4 AR e1001810 DI 10.1371/journal.pmed.1001810 PG 29 WC Medicine, General & Internal SC General & Internal Medicine GA CI5UQ UT WOS:000354825700001 PM 25849352 ER PT J AU Rigler, M Buh, J Hoffmann, MP Kirste, R Bobea, M Mita, S Gerhold, MD Collazo, R Sitar, Z Zgonik, M AF Rigler, Martin Buh, Joze Hoffmann, Marc P. Kirste, Ronny Bobea, Milena Mita, Seiji Gerhold, Michael D. Collazo, Ramon Sitar, Zlatko Zgonik, Marko TI Optical characterization of Al- and N-polar AlN waveguides for integrated optics SO APPLIED PHYSICS EXPRESS LA English DT Article ID EFFECTIVE-MEDIUM MODELS; SPECTROSCOPIC ELLIPSOMETRY; REFRACTIVE-INDEXES; SURFACE-ROUGHNESS; THIN-FILMS; GAN; GENERATION; GROWTH AB Dispersion of the extraordinary and ordinary refractive indices of Al- and N-polar AlN waveguides is measured by multiple angle-of-incidence and spectroscopic ellipsometry techniques. The polarity-controlled AlN layers are grown by metal-organic chemical vapor deposition on (0001)sapphire substrates. Taking into consideration the different surface morphologies of the Al-and N-polar AlN waveguides, we propose two optical models to describe the measured ellipsometry data. The results indicate that there is no difference between the refractive indices of the AlN grown in opposite directions, which confirms the potential of the AlN lateral polar structures for use in nonlinear optical applications based on quasi phase matching. (C) 2015 The Japan Society of Applied Physics C1 [Rigler, Martin; Zgonik, Marko] Univ Ljubljana, Fac Math & Phys, Ljubljana 1000, Slovenia. [Buh, Joze; Zgonik, Marko] Jozef Stefan Inst, Ljubljana 1000, Slovenia. [Hoffmann, Marc P.; Kirste, Ronny; Bobea, Milena; Collazo, Ramon; Sitar, Zlatko] N Carolina State Univ, Dept Mat Sci & Engn, Raleigh, NC 27606 USA. [Mita, Seiji] HexaTech Inc, Morrisville, NC 27606 USA. [Gerhold, Michael D.] Army Res Off, Engn Sci Directorate, Res Triangle Pk, NC 27703 USA. RP Rigler, M (reprint author), Univ Ljubljana, Fac Math & Phys, Jadranska 19, Ljubljana 1000, Slovenia. EM martin.rigler@fmf.uni-lj.si RI Zgonik, Marko/K-9092-2015 OI Zgonik, Marko/0000-0002-2307-8797 FU National Science Foundation [DMR-1108071, DMR-1312582]; Army Research Laboratory [W911NF-04- D-0003-0014] FX We acknowledge the CENN Nanocenter for allowing the use of the Accurion spectroscopic ellipsometer and the FEI focused ion beam. The North Carolina State University (NCSU) group acknowledges financial support from the National Science Foundation under contracts DMR-1108071 and DMR-1312582, and from the Army Research Laboratory (Contract No. W911NF-04- D-0003-0014, William Clark program monitor). NR 33 TC 4 Z9 4 U1 5 U2 22 PU IOP PUBLISHING LTD PI BRISTOL PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND SN 1882-0778 EI 1882-0786 J9 APPL PHYS EXPRESS JI Appl. Phys. Express PD APR PY 2015 VL 8 IS 4 AR 042603 DI 10.7567/APEX.8.042603 PG 4 WC Physics, Applied SC Physics GA CI4DK UT WOS:000354696900016 ER PT J AU Choi, I Chung, AW Suscovich, TJ Rerks-Ngarm, S Pitisuttithum, P Nitayaphan, S Kaewkungwal, J O'Connell, RJ Francis, D Robb, ML Michael, NL Kim, JH Alter, G Ackerman, ME Bailey-Kellogg, C AF Choi, Ickwon Chung, Amy W. Suscovich, Todd J. Rerks-Ngarm, Supachai Pitisuttithum, Punnee Nitayaphan, Sorachai Kaewkungwal, Jaranit O'Connell, Robert J. Francis, Donald Robb, Merlin L. Michael, Nelson L. Kim, Jerome H. Alter, Galit Ackerman, Margaret E. Bailey-Kellogg, Chris TI Machine Learning Methods Enable Predictive Modeling of Antibody Feature: Function Relationships in RV144 Vaccinees SO PLOS COMPUTATIONAL BIOLOGY LA English DT Article ID CELL-MEDIATED CYTOTOXICITY; HIV-1/SIV CHIMERIC VIRUS; NEUTRALIZING ANTIBODIES; DISEASE PROGRESSION; HIGH-THROUGHPUT; EFFICACY TRIAL; REGRESSION; INFECTION; VACCINATION; PROTECTION AB The adaptive immune response to vaccination or infection can lead to the production of specific antibodies to neutralize the pathogen or recruit innate immune effector cells for help. The non-neutralizing role of antibodies in stimulating effector cell responses may have been a key mechanism of the protection observed in the RV144 HIV vaccine trial. In an extensive investigation of a rich set of data collected from RV144 vaccine recipients, we here employ machine learning methods to identify and model associations between antibody features (IgG subclass and antigen specificity) and effector function activities (antibody dependent cellular phagocytosis, cellular cytotoxicity, and cytokine release). We demonstrate via cross-validation that classification and regression approaches can effectively use the antibody features to robustly predict qualitative and quantitative functional outcomes. This integration of antibody feature and function data within a machine learning framework provides a new, objective approach to discovering and assessing multivariate immune correlates. C1 [Choi, Ickwon; Bailey-Kellogg, Chris] Dartmouth Coll, Dept Comp Sci, Hanover, NH 03755 USA. [Chung, Amy W.; Suscovich, Todd J.; Alter, Galit] Massachusetts Gen Hosp, Ragon Inst, MIT, Boston, MA 02114 USA. [Chung, Amy W.; Suscovich, Todd J.; Alter, Galit] Harvard, Boston, MA USA. [Rerks-Ngarm, Supachai] Minist Publ Hlth, Dept Dis Control, Nonthaburi, Thailand. [Pitisuttithum, Punnee; Kaewkungwal, Jaranit] Mahidol Univ, Fac Trop Med, Bangkok, Thailand. [Nitayaphan, Sorachai] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [O'Connell, Robert J.] AFRIMS, US Army Med Component, Dept Retrovirol, Bangkok, Thailand. [Francis, Donald] Global Solut Infect Dis GSID, San Francisco, CA USA. [Robb, Merlin L.; Michael, Nelson L.; Kim, Jerome H.] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD USA. [Robb, Merlin L.] US Mil HIV Res Program, Henry Jackson Fdn HIV Program, Bethesda, MD USA. [Ackerman, Margaret E.] Dartmouth Coll, Thayer Sch Engn, Hanover, NH 03755 USA. RP Choi, I (reprint author), Dartmouth Coll, Dept Comp Sci, Hanover, NH 03755 USA. EM cbk@cs.dartmouth.edu OI Chung, Amy/0000-0003-0020-9704 FU US Military HIV Research Program (MHRP); Collaboration for AIDS Vaccine Discovery [OPP1032817]; NSF [IIS-0905206]; American Australian Association; National Health & Medical Research Center [NHMRC APP1036470]; U.S. Army Medical Research and Material Command (USAMRMC) [Y1-AI-2642-12]; National Institutes of Allergy and Infectious Diseases [Y1-AI-2642-12]; Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. [W81XWH-07-2-0067]; U.S. Department of Defense [W81XWH-07-2-0067]; [NIH3R01Al080289-02S1]; [5R01Al080289-03] FX These studies were supported by the US Military HIV Research Program (MHRP), the Collaboration for AIDS Vaccine Discovery (OPP1032817: Leveraging Antibody Effector Function) to MEA, GA, and CBK, and NIH3R01Al080289-02S1 and 5R01Al080289-03 to GA. IC was supported by NSF grant IIS-0905206. AWC was supported by the American Australian Association (Amgen Fellowship) and National Health & Medical Research Center (NHMRC APP1036470). The work was also supported in part by an Interagency Agreement Y1-AI-2642-12 between the U.S. Army Medical Research and Material Command (USAMRMC) and the National Institutes of Allergy and Infectious Diseases and by a cooperative agreement (W81XWH-07-2-0067) between the Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., and the U.S. Department of Defense. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 38 TC 4 Z9 4 U1 0 U2 5 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1553-734X EI 1553-7358 J9 PLOS COMPUT BIOL JI PLoS Comput. Biol. PD APR PY 2015 VL 11 IS 4 AR UNSP e1004185 DI 10.1371/journal.pcbi.1004185 PG 20 WC Biochemical Research Methods; Mathematical & Computational Biology SC Biochemistry & Molecular Biology; Mathematical & Computational Biology GA CI1PX UT WOS:000354517600034 PM 25874406 ER PT J AU Clark, MP Nijssen, B Lundquist, JD Kavetski, D Rupp, DE Woods, RA Freer, JE Gutmann, ED Wood, AW Brekke, LD Arnold, JR Gochis, DJ Rasmussen, RM AF Clark, Martyn P. Nijssen, Bart Lundquist, Jessica D. Kavetski, Dmitri Rupp, David E. Woods, Ross A. Freer, Jim E. Gutmann, Ethan D. Wood, Andrew W. Brekke, Levi D. Arnold, Jeffrey R. Gochis, David J. Rasmussen, Roy M. TI A unified approach for process-based hydrologic modeling: 1. Modeling concept SO WATER RESOURCES RESEARCH LA English DT Article DE unified model; scaling behavior; hydrometeorology ID GENERAL-CIRCULATION MODELS; STORAGE BOUSSINESQ MODEL; PHYSICALLY BASED MODEL; VARIABLE SOURCE AREAS; TORNE-KALIX BASIN; LAND-SURFACE; INTERCOMPARISON PROJECT; SUBSURFACE FLOW; HETEROGENEOUS HILLSLOPES; WATERSHED THERMODYNAMICS AB This work advances a unified approach to process-based hydrologic modeling to enable controlled and systematic evaluation of multiple model representations (hypotheses) of hydrologic processes and scaling behavior. Our approach, which we term the Structure for Unifying Multiple Modeling Alternatives (SUMMA), formulates a general set of conservation equations, providing the flexibility to experiment with different spatial representations, different flux parameterizations, different model parameter values, and different time stepping schemes. In this paper, we introduce the general approach used in SUMMA, detailing the spatial organization and model simplifications, and how different representations of multiple physical processes can be combined within a single modeling framework. We discuss how SUMMA can be used to systematically pursue the method of multiple working hypotheses in hydrology. In particular, we discuss how SUMMA can help tackle major hydrologic modeling challenges, including defining the appropriate complexity of a model, selecting among competing flux parameterizations, representing spatial variability across a hierarchy of scales, identifying potential improvements in computational efficiency and numerical accuracy as part of the numerical solver, and improving understanding of the various sources of model uncertainty. C1 [Clark, Martyn P.; Gutmann, Ethan D.; Wood, Andrew W.; Gochis, David J.; Rasmussen, Roy M.] Natl Ctr Atmospher Res, Hydrometeorol Applicat Program, Res Applicat Lab, Boulder, CO 80307 USA. [Nijssen, Bart; Lundquist, Jessica D.] Univ Washington, Dept Civil & Environm Engn, Seattle, WA 98195 USA. [Kavetski, Dmitri] Univ Adelaide, Sch Civil Environm & Min Engn, Adelaide, SA, Australia. [Rupp, David E.] Oregon State Univ, Oregon Climate Change Res Inst, Coll Earth Ocean & Atmospher Sci, Corvallis, OR 97331 USA. [Woods, Ross A.] Univ Bristol, Fac Engn, Bristol, Avon, England. [Freer, Jim E.] Univ Bristol, Sch Geog Sci, Bristol, Avon, England. [Brekke, Levi D.] US Bur Reclamat, Denver, CO 80225 USA. [Arnold, Jeffrey R.] US Army Corps Engineers, Seattle, WA USA. RP Clark, MP (reprint author), Natl Ctr Atmospher Res, Hydrometeorol Applicat Program, Res Applicat Lab, POB 3000, Boulder, CO 80307 USA. EM mclark@ucar.edu RI Woods, Ross/C-6696-2013; Freer, Jim/C-7335-2009; Clark, Martyn/A-5560-2015; Rupp, David/G-8171-2014; Nijssen, Bart/B-1013-2012; Gutmann, Ethan/I-5728-2012 OI Woods, Ross/0000-0002-5732-5979; Clark, Martyn/0000-0002-2186-2625; Nijssen, Bart/0000-0002-4062-0322; Gutmann, Ethan/0000-0003-4077-3430 FU U.S. Army Corps of Engineers; Bureau of Reclamation through National Oceanic and Atmospheric Administration (NOAA) Modeling Analysis Predictions and Projections (MAPP) program [R4310142]; National Science Foundation [EAR-1215809] FX We thank David Tarboton, Mary Hill, Michael Barlage, Fei Chen, and David Lawrence for comments on an earlier draft of this manuscript, and Cindy Halley-Gotway and Kevin Sampson for their help in producing the figures for the paper. We thank the three anonymous reviewers and Keith Beven for their detailed and constructive comments that substantially improved the manuscript. This work was supported through a contract with the U.S. Army Corps of Engineers, through a Cooperative Agreement with the Bureau of Reclamation, through a grant from the National Oceanic and Atmospheric Administration (NOAA) Modeling Analysis Predictions and Projections (MAPP) program (R4310142), and through a grant from the National Science Foundation (EAR-1215809). All of the spatial data used to create the figures in this paper are available from the lead author upon request. NR 128 TC 38 Z9 38 U1 16 U2 64 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA SN 0043-1397 EI 1944-7973 J9 WATER RESOUR RES JI Water Resour. Res. PD APR PY 2015 VL 51 IS 4 BP 2498 EP 2514 DI 10.1002/2015WR017198 PG 17 WC Environmental Sciences; Limnology; Water Resources SC Environmental Sciences & Ecology; Marine & Freshwater Biology; Water Resources GA CI4PH UT WOS:000354733500036 ER PT J AU Homeyer, DC Sanchez, CJ Mende, K Beckius, ML Murray, CK Wenke, JC Akers, KS AF Homeyer, Diane C. Sanchez, Carlos J. Mende, Katrin Beckius, Miriam L. Murray, Clinton K. Wenke, Joseph C. Akers, Kevin S. TI In Vitro activity of Melaleuca alternifolia (tea tree) oil on filamentous fungi and toxicity to human cells SO MEDICAL MYCOLOGY LA English DT Article DE cell viability; cytotoxicity; invasive fungal infection; Melaleuca alternifolia; tea tree oil ID RESISTANT STAPHYLOCOCCUS-AUREUS; DONOR SKIN VIABILITY; CUTANEOUS ASPERGILLOSIS; TOPICAL PREPARATIONS; MAJOR COMPONENTS; FIBROBLAST CELLS; CONTROLLED-TRIAL; AMPHOTERICIN-B; VORICONAZOLE; TERPINEN-4-OL AB Invasive fungal wound infections (IFIs) are increasingly reported in trauma patients and cause considerable morbidity and mortality despite standard of care treatment in trauma centers by experienced medical personnel. Topical agents such as oil of melaleuca, also known as tea tree oil (TTO), have been proposed for adjunctive treatment of IFIs. We evaluated the activity of TTO against filamentous fungi associated with IFIs by testing 13 clinical isolates representing nine species via time-kill assay with seven concentrations of TTO (100%, 75%, 50%, 25%, 10%, 5%, and 1%). To ascertain the safety of topical application to wounds, cell viability assays were performed in vitro using human fibroblasts, keratinocytes, osteoblasts, and umbilical vein endothelial cells with 10 concentrations of TTO (75%, 50%, 25%, 10%, 5%, and 10-fold serial dilutions from 1 to 0.0001%) at five time points (5, 15, 30, 60, and 180 min). Compatibility of TTO with explanted porcine tissues was also assessed with eight concentrations of TTO (100%, 75%, 50%, 25%, 10%, 5%, 1%, and 0.1%) at the time points used for cellular assays and at 24 h. The time-kill studies showed that fungicidal activity was variable between isolates. The effect of TTO on cell viability was primarily concentration dependent with significant cytotoxicity at concentrations of >= 10% and >= 50% for cells lines and whole tissue, respectively. Our findings demonstrate that TTO possesses antifungal activity against filamentous fungi associated with IFIs; furthermore that negligible effects on whole tissues, in contrast to individual cells, were observed following exposure to TTO. Collectively, these findings indicate a potential use of TTO as topical treatment of IFIs. C1 [Homeyer, Diane C.; Mende, Katrin; Murray, Clinton K.; Akers, Kevin S.] San Antonio Mil Med Ctr, Dept Med, Infect Dis Serv, Ft Sam Houston, TX 78234 USA. [Sanchez, Carlos J.; Wenke, Joseph C.; Akers, Kevin S.] US Army Inst Surg Res, Extrem Trauma & Regenerat Med Task Area, Ft Sam Houston, TX USA. [Mende, Katrin] Uniformed Serv Univ Hlth Sci, Infect Dis Clin Res Program, Bethesda, MD 20814 USA. [Beckius, Miriam L.] Brooke Army Med Ctr, Dept Clin Invest, Ft Sam Houston, TX 78234 USA. RP Homeyer, DC (reprint author), San Antonio Mil Med Ctr, Dept Med, Infect Dis Serv, Ft Sam Houston, TX 78234 USA. EM dchomeyer@gmail.com FU Armed Forces Health Surveillance Center; Global Emerging Infections Surveillance and Response System; Combat Casualty Research Program, Medical Research and Material Command FX The views expressed herein are those of the authors and do not reflect the official policy or position of the Department of the Army, Department of the Air Force, Department of Defense, or the US Government. The authors are employees of the US government. This work was prepared as part of their official duties, and as such, there is no copyright to be transferred. This work was supported by the Armed Forces Health Surveillance Center including the Global Emerging Infections Surveillance and Response System and by intramural funding from the Combat Casualty Research Program, Medical Research and Material Command to JCW. NR 45 TC 1 Z9 1 U1 0 U2 13 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 1369-3786 EI 1460-2709 J9 MED MYCOL JI Med. Mycol. PD APR PY 2015 VL 53 IS 3 BP 285 EP 294 DI 10.1093/mmy/myu072 PG 10 WC Infectious Diseases; Mycology; Veterinary Sciences SC Infectious Diseases; Mycology; Veterinary Sciences GA CI1VK UT WOS:000354532800010 PM 25631479 ER PT J AU Choi, JH Greene, WA Johnson, AJ Chavko, M Cleland, JM McCarron, RM Wang, HC AF Choi, Jae Hyek Greene, Whitney A. Johnson, Anthony J. Chavko, Mikulas Cleland, Jeffery M. McCarron, Richard M. Wang, Heuy-Ching TI Pathophysiology of blast-induced ocular trauma in rats after repeated exposure to low-level blast overpressure SO CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY LA English DT Article DE apoptosis; blast-induced ocular trauma; blast overpressure; gliosis; optic neuropathy ID FIBRILLARY ACIDIC PROTEIN; EXPERIMENTAL RODENT MODEL; GANGLION-CELL DAMAGE; BRAIN-INJURY; RETINAL DEGENERATION; MOUSE MODEL; EYE; EXPRESSION; PATTERN; COMBAT AB BackgroundThe incidence of blast-induced ocular injury has dramatically increased due to advances in weaponry and military tactics. A single exposure to blast overpressure (BOP) has been shown to cause damage to the eye in animal models; however, on the battlefield, military personnel are exposed to BOP multiple times. The effects of repeated exposures to BOP on ocular tissues have not been investigated. The purpose of this study is to characterize the effects of single or repeated exposure on ocular tissues. MethodsA compressed air shock tube was used to deliver 707KPa BOP to rats, once (single blast overpressure [SBOP]) or once daily for 5 days (repeated blast overpressure [RBOP]). Immunohistochemistry was performed to characterize the pathophysiology of ocular injuries induced by SBOP and RBOP. Apoptosis was determined by quantification activated caspase 3. Gliosis was examined by detection of glial fibrillary acidic protein (GFAP). Inflammation was examined by detection of CD68. ResultsActivated caspase 3 was detected in ocular tissues from all animals subjected to BOP, while those exposed to RBOP had more activated caspase 3 in the optic nerve than those exposed to SBOP. GFAP was detected in the retinas from all animals subjected to BOP. CD68 was detected in optic nerves from all animals exposed to BOP. ConclusionSBOP and RBOP induced retinal damage. RBOP caused more apoptosis in the optic nerve than SBOP, suggesting that RBOP causes more severe optic neuropathy than SBOP. SBOP and RBOP caused gliosis in the retina and increased inflammation in the optic nerve. C1 [Choi, Jae Hyek; Greene, Whitney A.; Johnson, Anthony J.; Cleland, Jeffery M.; Wang, Heuy-Ching] US Army Inst Surg Res, Ocular Trauma Task Area, Jbsa Ft Sam Houston, TX USA. [Chavko, Mikulas; McCarron, Richard M.] Naval Med Res Ctr, NeuroTrauma Dept, Silver Spring, MD USA. RP Wang, HC (reprint author), US Army Inst Surg Res, 3698 Chambers Pass Ave,Bldg 3611, San Antonio, TX 78234 USA. EM heuy-ching.h.wang.civ@mail.mil FU U.S. Army Military Operational Medicine Research Program (MOMRP); Clinical Rehabilitative Medicine Research Program (CRMRP) FX U.S. Army Military Operational Medicine Research Program (MOMRP) and Clinical Rehabilitative Medicine Research Program (CRMRP). NR 30 TC 3 Z9 3 U1 3 U2 6 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1442-6404 EI 1442-9071 J9 CLIN EXP OPHTHALMOL JI Clin. Exp. Ophthalmol. PD APR PY 2015 VL 43 IS 3 BP 239 EP 246 DI 10.1111/ceo.12407 PG 8 WC Ophthalmology SC Ophthalmology GA CH4RK UT WOS:000354020400008 PM 25112787 ER PT J AU Pasiakos, SM Margolis, LM Orr, JS AF Pasiakos, Stefan M. Margolis, Lee M. Orr, Jeb S. TI Optimized dietary strategies to protect skeletal muscle mass during periods of unavoidable energy deficit SO FASEB JOURNAL LA English DT Review DE leucine; military; mTORC1; lean body mass ID ESSENTIAL AMINO-ACID; RANDOMIZED CONTROLLED-TRIAL; HEALTHY-YOUNG MEN; GROWTH-FACTOR-I; FAT-FREE MASS; WEIGHT-LOSS; BODY-COMPOSITION; RESISTANCE EXERCISE; PHYSICAL PERFORMANCE; ENDURANCE EXERCISE AB Interactions between dietary protein and energy balance on the regulation of human skeletal muscle protein turnover are not well described. A dietary protein intake above the recommended dietary allowance during energy balance typically enhances nitrogen retention and up-regulates muscle protein synthesis, which in turn may promote positive protein balance and skeletal muscle accretion. Recent studies show that during energy deficit, muscle protein synthesis is down-regulated with concomitant increases in ubiquitin proteasome-mediated muscle proteolysis and nitrogen excretion, reflecting the loss of skeletal muscle mass. However, consuming high-protein diets (1.6-2.4 g/kg per day), or high-quality, protein-based meals (15-30 g whey) during energy deficit attenuates intracellular proteolysis, restores muscle protein synthesis, and mitigates skeletal muscle loss. These findings are particularly important for physically active, normal-weight individuals because attenuating the extent to which skeletal muscle mass is lost during energy deficit could prevent decrements in performance, reduce injury risk, and facilitate recovery. This article reviews the relationship between energy status, protein intake, and muscle protein turnover, and explores future research directives designed to protect skeletal muscle mass in physically active, normal-weight adults. C1 [Pasiakos, Stefan M.; Margolis, Lee M.; Orr, Jeb S.] US Army, Environm Med Res Inst, Mil Nutr Div, Natick, MA 01760 USA. RP Pasiakos, SM (reprint author), US Army, Environm Med Res Inst, 15 Kansas St,Bldg 42, Natick, MA 01760 USA. EM stefan.pasiakos@usarmy.mil RI Pasiakos, Stefan/E-6295-2014; OI Pasiakos, Stefan/0000-0002-5378-5820; , Lee/0000-0002-0652-1304 FU U.S. Army Medical Research and Material Command FX The authors thank Dr. Scott J. Montain for his support in the development of this article. This work was supported by the U.S. Army Medical Research and Material Command. The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the U.S. Army or the U.S. Department of Defense. Any citations of commercial organizations and trade names in this report do not constitute an official U.S. Department of the Army endorsement of approval of the products or services of these organizations. NR 119 TC 8 Z9 8 U1 1 U2 15 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 EI 1530-6860 J9 FASEB J JI Faseb J. PD APR PY 2015 VL 29 IS 4 BP 1136 EP 1142 DI 10.1096/fj.14-266890 PG 7 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA CH5ZN UT WOS:000354115000003 PM 25550460 ER PT J AU Lee, JC Nakama, H Goebert, D Alicata, D AF Lee, June C. Nakama, Helenna Goebert, Deborah Alicata, Daniel TI Gender differences in reasons for methamphetamine use in an ethnically diverse population in Hawaii SO JOURNAL OF SUBSTANCE USE LA English DT Article DE Amphetamine; mental health; sexual behaviours; substance use; women ID MEN AB Objectives: This preliminary study examined methamphetamine (MA) use behaviors and motivators for MA use among 46 ethnically diverse participants from an university-affiliated community hospital and narcotics anonymous groups in Hawaii. Method: Data were collected among 46 participants using an anonymous survey. Results: Results showed that both women and men use MA primarily to get high and to get more energy. Women were more likely than men to use MA to cope with negative feelings and for increased energy. Men were more likely than women to use MA for sexual reasons and due to peer pressure. Conclusion: These results suggest that some women may be self-medicating with MA. Studying these behaviors may guide in developing future prevention and treatment strategies. C1 [Lee, June C.; Goebert, Deborah; Alicata, Daniel] Univ Hawaii, Dept Psychiat, Honolulu, HI 96822 USA. [Nakama, Helenna] Tripler Army Med Ctr, Dept Behav Hlth, Honolulu, HI USA. RP Lee, JC (reprint author), 1356 Lusitana St,4th Floor Honolulu, Honolulu, HI 96813 USA. EM jlee@dop.hawaii.edu NR 10 TC 0 Z9 0 U1 5 U2 8 PU INFORMA HEALTHCARE PI NEW YORK PA 52 VANDERBILT AVE, NEW YORK, NY 10017 USA SN 1465-9891 EI 1475-9942 J9 J SUBST USE JI J. Subst. Use PD APR PY 2015 VL 20 IS 2 BP 93 EP 96 DI 10.3109/14659891.2013.859753 PG 4 WC Substance Abuse SC Substance Abuse GA CH3LN UT WOS:000353932300003 ER PT J AU Pollard, KA Tran, PK Letowski, T AF Pollard, Kimberly A. Tran, Phuong K. Letowski, Tomasz TI The effect of vocal and demographic traits on speech intelligibility over bone conduction SO JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA LA English DT Article ID FUNDAMENTAL-FREQUENCY CHARACTERISTICS; ACQUISITION TEST CAT; INDIVIDUAL-DIFFERENCES; BACKGROUND-NOISE; AGE; SPEAKING; HEARING; ADULTS; SEX; MICROPHONES AB Bone conduction (BC) communication systems provide benefits over air conduction systems but are not in widespread use, partly due to problems with speech intelligibility. Contributing factors like device location and background noise have been explored, but little attention has been paid to the role of individual user differences. Because BC signals travel through an individual's skull and facial tissues, demographic factors such as user age, sex, race, or regional origin may influence sound transmission. Vocal traits such as pitch, spectral tilt, jitter, and shimmer may also play a role. Along with microphone placement and background noise, these factors can affect BC speech intelligibility. Eight diverse talkers were recorded with bone microphones on two different skull locations and in different background noise conditions. Twenty-four diverse listeners listened to these samples over BC and completed Modified Rhyme Tests for speech intelligibility. Forehead bone recordings were more intelligible than condyle recordings. In condyle recordings, female talkers, talkers with high fundamental frequency, and talkers in background noise were understood better, as were communications between talkers and listeners of the same regional origin. Listeners' individual traits had no significant effects. Thoughtful application of this knowledge can help improve BC communication for diverse users. C1 [Pollard, Kimberly A.; Tran, Phuong K.; Letowski, Tomasz] US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Pollard, KA (reprint author), US Army Res Lab, 520 Mulberry Point Rd, Aberdeen Proving Ground, MD 21005 USA. EM kpollard@ucla.edu FU Oak Ridge Associated Universities postdoctoral fellowship FX The authors thank Tim Mermagen for developing the MRT software, Paula Henry and Ashley Foots for hearing screenings and training, and Rachel Weatherless, Debra Patton, Jeremy Gaston, and Bruce Amrein for helpful comments. This research was conducted under an Oak Ridge Associated Universities postdoctoral fellowship to K.A.P. NR 67 TC 1 Z9 1 U1 0 U2 2 PU ACOUSTICAL SOC AMER AMER INST PHYSICS PI MELVILLE PA STE 1 NO 1, 2 HUNTINGTON QUADRANGLE, MELVILLE, NY 11747-4502 USA SN 0001-4966 EI 1520-8524 J9 J ACOUST SOC AM JI J. Acoust. Soc. Am. PD APR PY 2015 VL 137 IS 4 BP 2060 EP 2069 DI 10.1121/1.4916689 PG 10 WC Acoustics; Audiology & Speech-Language Pathology SC Acoustics; Audiology & Speech-Language Pathology GA CG9QV UT WOS:000353653500060 PM 25920856 ER PT J AU Florio, LA AF Florio, L. A. TI Dynamic coupling of fluid and structural mechanics for simulating particle motion and interaction in high speed compressible gas particle laden flow SO JOURNAL OF FLUIDS AND STRUCTURES LA English DT Article DE Fluid-structure interaction; Computational fluid dynamics; Finite element analysis; Particle flow; Two-phase; Plasticity ID MOVING PARTICLES; HEAT-CONDUCTION; MODEL; COLLISIONS; DEFORMATION; BEHAVIOR; COMPUTATION; NUMBER AB In this work, structural finite element analyses of particles moving and interacting within high speed compressible flow are directly coupled to computational fluid dynamics and heat transfer analyses to provide more detailed and improved simulations of particle laden flow under these operating conditions. For a given solid material model, stresses and displacements throughout the solid body are determined with the particle-particle contact following an element to element local spring force model and local fluid induced forces directly calculated from the finite volume flow solution. Plasticity and particle deformation common in such a flow regime can be incorporated in a more rigorous manner than typical discrete element models where structural conditions are not directly modeled. Using the developed techniques, simulations of normal collisions between two I mm radius particles with initial particle velocities of 50-150 m/s are conducted with different levels of pressure driven gas flow moving normal to the initial particle motion for elastic and elastic-plastic with strain hardening based solid material models. In this manner, the relationships between the collision velocity, the material behavior models, and the fluid flow and the particle motion and deformation can be investigated. The elastic-plastic material behavior results in post collision velocities 16-50% of their precollision values while the elastic-based particle collisions nearly regained their initial velocity upon rebound. The elastic-plastic material models produce contact forces less than half of those for elastic collisions, longer contact times, and greater particle deformation. Fluid flow forces affect the particle motion even at high collision speeds regardless of the solid material behavior model. With the elastic models, the collision force varied little with the strength of the gas flow driver. For the elastic-plastic models, the larger particle deformation and the resulting increasingly asymmetric loading lead to growing differences in the collision force magnitudes and directions as the gas flow strength increased. The coupled finite volume flow and finite element structural analyses provide a capability to capture the interdependencies between the interaction of the particles, the particle deformation, the fluid flow and the particle motion. Published by Elsevier Ltd. C1 US Army ARDEC, Technol Branch, Small Caliber Armaments Div, Picatinny Arsenal, NJ 07806 USA. RP Florio, LA (reprint author), US Army ARDEC, Technol Branch, Small Caliber Armaments Div, Picatinny Arsenal, NJ 07806 USA. EM laurie.a.florio.civ@mail.mil FU ARDEC In-House Laboratory Independent Research Project; DoD High Performance Computing Modernization Program at ARL; AFRL; ERDC FX This work was funded by an ARDEC In-House Laboratory Independent Research Project.; This work was supported in part by a grant of computer time from the DoD High Performance Computing Modernization Program at ARL, AFRL, and ERDC. NR 47 TC 2 Z9 2 U1 0 U2 15 PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD PI LONDON PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND SN 0889-9746 J9 J FLUID STRUCT JI J. Fluids Struct. PD APR PY 2015 VL 54 BP 171 EP 201 DI 10.1016/j.jfluidstructs.2014.10.014 PG 31 WC Engineering, Mechanical; Mechanics SC Engineering; Mechanics GA CH0SF UT WOS:000353732000008 ER PT J AU Umthong, S Buaklin, A Jacquet, A Sangjun, N Kerdkaew, R Patarakul, K Palaga, T AF Umthong, Supawadee Buaklin, Arun Jacquet, Alain Sangjun, Noppadol Kerdkaew, Ruthairat Patarakul, Kanitha Palaga, Tanapat TI Immunogenicity of a DNA and Recombinant Protein Vaccine Combining LipL32 and Loa22 for Leptospirosis Using Chitosan as a Delivery System SO JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY LA English DT Article DE Leptospirosis; DNA vaccine; chitosan; immunogenicity ID OUTER-MEMBRANE PROTEINS; T-CELL RESPONSES; TUBERCULOSIS VACCINE; INTERROGANS; LIPOPROTEIN; INFECTION; IMMUNITY; SEROVAR; PRIME; BOOST AB Leptospirosis is a worldwide zoonotic disease caused by pathogenic Leptospira, a genus of which more than 250 serovars have been identified. Commercial bacterin vaccines are limited in that they lack both cross-protection against heterologous serovars and long-term protection. This study investigated in mice the immunogenicity of an anti-leptospirosis vaccine, using the outer membrane proteins LipL32 and Loa22 as antigens. The immunogenicity of this vaccine formulation was compared with those induced by vaccines based on LipL32 or Loa22 alone. A DNA-encapsulated chitosan nanoparticle was used for in vivo DNA delivery. Using a unique DNA plasmid expressing both lipL32 and loa22 for vaccination, higher antibody responses were induced than when combining plasmids harboring each gene separately. Therefore, this formulation was used to test the immunogenicity when administered by a heterologous prime (DNA)-boost (protein) immunization regimen. The specific antibody responses against LipL32 (total IgG and IgG1) and Loa22 (IgG1) were higher in mice receiving two antigens in combination than in those vaccinated with a single antigen alone. Although no significant difference in splenic CD4(+) T cell proliferation was observed among all groups of vaccinated mice, splenocytes from mice vaccinated with two antigens exhibited higher interferon-gamma and IL-2 production than when using single antigens alone upon in vitro restimulation. Taken together, the immunogenicity induced by LipL32 and Loa22 antigens in a heterologous prime-boost immunization regimen using chitosan as a DNA delivery system induces higher immune response, and may be useful for developing a better vaccine for leptospirosis. C1 [Umthong, Supawadee; Kerdkaew, Ruthairat; Patarakul, Kanitha; Palaga, Tanapat] Chulalongkorn Univ, Grad Sch, Interdisciplinary Program Med Microbiol, Bangkok 10330, Thailand. [Buaklin, Arun; Patarakul, Kanitha] Chulalongkorn Univ, Fac Med, Dept Microbiol, Bangkok 10330, Thailand. [Buaklin, Arun; Jacquet, Alain; Patarakul, Kanitha; Palaga, Tanapat] Chulalongkorn Univ, Vaccine Res Ctr, Bangkok 10330, Thailand. [Jacquet, Alain] Chulalongkorn Univ, Fac Med, Dept Med, Bangkok 10330, Thailand. [Sangjun, Noppadol] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Palaga, Tanapat] Chulalongkorn Univ, Dept Microbiol, Fac Sci, Bangkok 10330, Thailand. RP Palaga, T (reprint author), Chulalongkorn Univ, Grad Sch, Interdisciplinary Program Med Microbiol, Bangkok 10330, Thailand. EM kanitha.pa@chula.ac.th; tanapat.p@chula.ac.th FU Higher Education Research Promotion; National Research University Project of Thailand, Office of the Higher Education Commission [HR1164A2]; Special Task Force for Activating Research (STAR) from the Centenary Academic Development Project (Chulalongkorn University); National Research Council of Thailand (NRCT); Research, Development and Engineering (RD&E) fund through The National Nanotechnology Center (NANOTEC); National Science and Technology Development Agency (NSTDA), Thailand [P-10-10454]; Thai Government Stimulus Package 2 under the Project for the Establishment of Innovative Food and Health Products and Agriculture [TKK2555]; post-doctoral fellowship (Rachadapisek Sompote Endowment Fund) from Chulalongkorn University Graduate School; Development and Promotion of Science and Technology Talents Project (DPST) FX This work was supported by the Higher Education Research Promotion and the National Research University Project of Thailand, Office of the Higher Education Commission (HR1164A2), the Special Task Force for Activating Research (STAR) from the Centenary Academic Development Project (Chulalongkorn University), and the National Research Council of Thailand (NRCT). The authors would like to acknowledge financial support from the Research, Development and Engineering (RD&E) fund through The National Nanotechnology Center (NANOTEC), the National Science and Technology Development Agency (NSTDA), Thailand (Project No. P-10-10454) to Chulalongkorn University. The equipment used in this study was purchased with funds from the Thai Government Stimulus Package 2 (TKK2555) under the Project for the Establishment of Innovative Food and Health Products and Agriculture. Arun Buaklin was sponsored by a post-doctoral fellowship (Rachadapisek Sompote Endowment Fund) from Chulalongkorn University Graduate School. Supawadee Umthong was supported by the Development and Promotion of Science and Technology Talents Project (DPST). NR 40 TC 4 Z9 4 U1 4 U2 12 PU KOREAN SOC MICROBIOLOGY & BIOTECHNOLOGY PI SEOUL PA KOREA SCI TECHNOL CENTER #507, 635-4 YEOGSAM-DONG, KANGNAM-GU, SEOUL 135-703, SOUTH KOREA SN 1017-7825 EI 1738-8872 J9 J MICROBIOL BIOTECHN JI J. Microbiol. Biotechnol. PD APR PY 2015 VL 25 IS 4 BP 526 EP 536 DI 10.4014/jmb.1408.08007 PG 11 WC Biotechnology & Applied Microbiology; Microbiology SC Biotechnology & Applied Microbiology; Microbiology GA CG9TW UT WOS:000353664000015 PM 25348693 ER PT J AU Reinke, EN Bera, S Diamond, AM AF Reinke, Emily N. Bera, Soumen Diamond, Alan M. TI Exposure of chronic myelogenous leukemia cells to imatinib results in the post-transcriptional induction of manganese superoxide dismutase SO LEUKEMIA & LYMPHOMA LA English DT Article DE CML; MnSOD; innatinib; cell lines ID CHRONIC MYELOID-LEUKEMIA; CML CELLS; RESISTANCE; CANCER AB The treatment of chronic myelogenous leukemia (CML) with specific tyrosine kinase inhibitors typically results in clinical success, although therapeutic failure frequently occurs. In order to investigate the biological consequences of treating CML cells with such drugs, we previously reported that the antioxidant selenoprotein glutathione peroxidase-1 (GPx-1) was induced by imatinib in both patient samples and cultured cells. Here, we extend these findings to demonstrate that the treatment of CML cell lines, but not non-CML cells, results in an approximately four-fold increase in the levels of another important antioxidant protein, manganese superoxide dismutase (MnSOD), without altering the steady state levels of the corresponding transcript. C1 [Reinke, Emily N.; Bera, Soumen; Diamond, Alan M.] Univ Illinois, Pathol, Chicago, IL USA. RP Reinke, EN (reprint author), US Army Publ Hlth Command, Army Inst Publ Hlth, 5158 Blackhawk Rd ATTN MCHB IP THE, Aberdeen Proving Ground, MD 21010 USA. EM emily.n.reinke.civ@mail.mil FU National Institutes of Health (NIH) [R21CA129590] FX This work was supported by a Grant from the National Institutes of Health (NIH) #R21CA129590 to A.M.D. NR 16 TC 0 Z9 0 U1 0 U2 0 PU INFORMA HEALTHCARE PI LONDON PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND SN 1042-8194 EI 1029-2403 J9 LEUKEMIA LYMPHOMA JI Leuk. Lymphoma PD APR PY 2015 VL 56 IS 4 BP 1096 EP 1099 DI 10.3109/10428194.2014.944521 PG 4 WC Oncology; Hematology SC Oncology; Hematology GA CG9CT UT WOS:000353612700042 PM 25039350 ER PT J AU Brunye, TT Mahoney, CR Taylor, HA AF Brunye, Tad T. Mahoney, Caroline R. Taylor, Holly A. TI PATHS WITH MORE TURNS ARE PERCEIVED AS LONGER: MISPERCEPTIONS WITH MAP-BASED AND ABSTRACTED PATH STIMULI SO PERCEPTUAL AND MOTOR SKILLS LA English DT Article ID SPATIAL MEMORY; COGNITIVE MAPS; DISTANCE COGNITION; TRAVERSED DISTANCE; GENDER-DIFFERENCES; SEX-DIFFERENCES; PERCEPTION; DISTORTIONS; DIRECTION; STRATEGIES AB When navigating, people tend to overestimate distances when routes contain more turns, termed the route-angularity effect. Three experiments examined the source and generality of this effect. The first two experiments examined whether route-angularity effects occur while viewing maps and might be related to sex differences or sense of direction. The third experiment tested whether the route-angularity effect would occur with stimuli devoid of spatial context, reducing influences of environmental experience and visual complexity. In the three experiments, participants (N = 1,552; M = 32.2 yr.; 992 men, 560 women) viewed paths plotted on maps (Exps. 1 and 2) or against a blank background (Exp. 3). The depicted paths were always the same overall length, but varied in the number of turns (from 1 to 7) connecting an origin and destination. Participants were asked to estimate the time to traverse each path (Exp. 1) or the length of each path (Exps. 2 and 3). The Santa Barbara Sense of Direction questionnaire was administered to assess whether overall spatial sense of direction would be negatively related to the magnitude of the route-angularity effect. Repeated-measures analyses of variance (ANOVAs) indicated that paths with more turns elicited estimates of greater distance and travel times, whether they were depicted on maps or blank backgrounds. Linear regressions also indicated that these effects were significantly larger in those with a relatively low sense of direction. The results support the route-angularity effect and extend it to paths plotted on map-based stimuli. Furthermore, because the route-angularity effect was shown with paths plotted against blank backgrounds, route-angularity effects are not specific to understanding environments and may arise at the level of visual perception. C1 [Brunye, Tad T.; Mahoney, Caroline R.] US Army, Natick Soldier Res Dev & Engn Ctr, Cognit Sci Team, Natick, MA 01760 USA. [Brunye, Tad T.; Mahoney, Caroline R.; Taylor, Holly A.] Tufts Univ, Dept Psychol, Medford, MA USA. RP Brunye, TT (reprint author), US Army, NSRDEC, Attn RDNS WSH S,15 Kansas St, Natick, MA 01760 USA. EM tbruny01@tufts.edu FU U.S. Army Natick Soldier Research, Development, and Engineering Center [W911QY13C0012] FX This work was supported by the U.S. Army Natick Soldier Research, Development, and Engineering Center (Grant Number W911QY13C0012). NR 57 TC 1 Z9 1 U1 1 U2 3 PU AMMONS SCIENTIFIC, LTD PI MISSOULA PA PO BOX 9229, MISSOULA, MT 59807-9229 USA SN 0031-5125 J9 PERCEPT MOTOR SKILL JI Percept. Mot. Skills PD APR PY 2015 VL 120 IS 2 BP 438 EP 461 DI 10.2466/22.PMS.120v11x2 PG 24 WC Psychology, Experimental SC Psychology GA CG8OD UT WOS:000353566700007 PM 25799028 ER PT J AU Hurley, KA Heinrich, VA Hershfield, JR Demons, ST Weibel, DB AF Hurley, Katherine A. Heinrich, Victoria A. Hershfield, Jeremy R. Demons, Samandra T. Weibel, Douglas B. TI Membrane-Targeting DCAP Analogues with Broad-Spectrum Antibiotic Activity against Pathogenic Bacteria SO ACS MEDICINAL CHEMISTRY LETTERS LA English DT Article DE Antibiotic; chemotherapeutic; antimicrobial; bacterial membrane; broad-spectrum activity ID ESCHERICHIA-COLI; IDENTIFICATION; NOVOBIOCIN; INHIBITORS; GYRASE AB We performed a structure activity relationship study of 2-((3-(3,6-dichloro-9H-carbazol-9-yl)-2-hydroxypropyl)amino)-2-(hydroxymethyl)propane-1,3-diol (DCAP), which is an antibacterial agent that disrupts the membrane potential and permeability of bacteria. The stereochemistry of DCAP had no effect on the biological activity of DCAP. The aromaticity and electronegativity of the chlorine-substituted carbazole was required for activity, suggesting that its planar and dipolar characteristics orient DCAP in membranes. Increasing the hydrophobicity of the tail region of DCAP enhanced its antibiotic activity. Two DCAP analogues displayed promising antibacterial activity against the BSL-3 pathogens Bacillus anthracis and Francisella tularensis. Codosing DCAP analogues with ampicillin or kanamycin increased their potency. These studies demonstrate that DCAP and its analogues may be a promising scaffold for developing chemotherapeutic agents that bind to bacterial membranes and kill strains of slow-growing or dormant bacteria that cause persistent infections. C1 [Hurley, Katherine A.; Heinrich, Victoria A.; Weibel, Douglas B.] Univ Wisconsin, Dept Biochem, Madison, WI 53706 USA. [Weibel, Douglas B.] Univ Wisconsin, Dept Chem, Madison, WI 53706 USA. [Hershfield, Jeremy R.; Demons, Samandra T.] US Army Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. RP Weibel, DB (reprint author), Univ Wisconsin, Dept Biochem, Madison, WI 53706 USA. EM weibel@biochem.wisc.edu FU National Institutes of Health [1DP2OD008735]; Human Frontiers Science Program [RGY0076/2013]; Defense Threat Reduction Agency under USAMRIID [922141]; American Foundation for Pharmaceutical Education (AFPE) FX This research was supported by grants from the National Institutes of Health (1DP2OD008735), the Human Frontiers Science Program (RGY0076/2013), and Defense Threat Reduction Agency under USAMRIID (Proj. #922141). K.A.H. acknowledges a fellowship from the American Foundation for Pharmaceutical Education (AFPE). NR 25 TC 4 Z9 4 U1 4 U2 16 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1948-5875 J9 ACS MED CHEM LETT JI ACS Med. Chem. Lett. PD APR PY 2015 VL 6 IS 4 BP 466 EP 471 DI 10.1021/acsmedchemlett.5b00024 PG 6 WC Chemistry, Medicinal SC Pharmacology & Pharmacy GA CG2IO UT WOS:000353098300019 PM 25941556 ER PT J AU Samy, RP Thwin, MM Stiles, BG Satyanarayana-Jois, S Chinnathambi, A Zayed, ME Alharbi, SA Siveen, KS Sikka, S Kumar, AP Sethi, G Lim, LHK AF Samy, Ramar Perumal Thwin, Maung Maung Stiles, Brad G. Satyanarayana-Jois, Seetharama Chinnathambi, Arunachalam Zayed, M. E. Alharbi, Sulaiman Ali Siveen, Kodappully Sivaraman Sikka, Sakshi Kumar, Alan Prem Sethi, Gautam Lim, Lina Hsiu Kim TI Novel phospholipase A(2) inhibitors from python serum are potent peptide antibiotics SO BIOCHIMIE LA English DT Article DE Phospholipase A(2) inhibitory peptide (PLI); Bacteria; Python serum; Antibacterial; Multi-drug resistance ID SOFT-TISSUE INFECTIONS; PLATELET-AGGREGATION INHIBITOR; ALTERNATUS SNAKE-VENOM; GROWTH-FACTOR-BETA; NF-KAPPA-B; ANTIMICROBIAL PEPTIDES; BOTHROPS-JARARACUSSU; ANTIINFLAMMATORY ACTIVITY; STAPHYLOCOCCUS-AUREUS; NONVENOMOUS SNAKE AB Antimicrobial peptides (AMPs) play a vital role in defense against resistant bacteria. In this study, eight different AMPs synthesized from Python reticulatus serum protein were tested for bactericidal activity against various Gram-positive and Gram-negative bacteria (Staphylococcus aureus, Burkholderia pseudomallei (KHW and TES strains), and Proteus vulgaris) using a disc-diffusion method (20 mu g/disc). Among the tested peptides, phospholipase A(2) inhibitory peptide (PIP)-18[59-76], beta-Asp65-PIP[59-67], D-Ala66-PNT.II, and D60,65E-PIP[59-67] displayed the most potent bactericidal activity against all tested pathogens in a dose-dependent manner (100-6.8 mu g/ml), with a remarkable activity noted against S. aureus at 6.8 mu g/ml dose within 6 h of incubation. Determination of minimum inhibitory concentrations (MICs) by a micro-broth dilution method at 100-3.125 mu g/ml revealed that PIP-18[59-76], beta-Asp65-PIP[59-67] and D-Ala66-PNT.II peptides exerted a potent inhibitory effect against S. aureus and B. pseudomallei (KHW) (MICs 3.125 mu g/ml), while a much less inhibitory potency (MICs 12.5 mu g/ml) was noted for beta-Asp65-PIP[59-67] and D-Ala66-PNT.II peptides against B. pseudomallei (TES). Higher doses of peptides had no effect on the other two strains (i.e., Klebsiella pneumoniae and Streptococcus pneumoniae). Overall, PIP-18[59-76] possessed higher antimicrobial activity than that of chloramphenicol (CHL), ceftazidime (CF) and streptomycin (ST) (30 mu g/disc). When the two most active peptides, PIP-18[59-76] and beta-Asp65-PIP[59-67], were applied topically at a 150 mg/kg dose for testing wound healing activity in a mouse model of S. aureus infection, the former accelerates faster wound healing than the latter peptide at 14 days post-treatment. The western blot data suggest that the topical application of peptides (PIP-18 [59-67] and beta-Asp65-PIP[59-67]) modulates NF-kB mediated wound repair in mice with relatively little haemolytic (100-1.56 mu g/ml) and cytotoxic (1000-3.125 mu g/ml) effects evident on human cells in vitro. (C) 2015 Published by Elsevier B.V. C1 [Samy, Ramar Perumal; Thwin, Maung Maung] Natl Univ Singapore, Venom & Toxin Res Programme, Yong Loo Lin Sch Med, Dept Anat,Natl Univ Hlth Syst, Singapore 117597, Singapore. [Samy, Ramar Perumal] Natl Univ Singapore, Yong Loo Lin Sch Med, Natl Univ Hlth Syst, Dept Microbiol, Singapore 117597, Singapore. [Samy, Ramar Perumal; Lim, Lina Hsiu Kim] Natl Univ Singapore, Dept Physiol, NUHS, Ctr Life Sci,Yong Loo Lin Sch Med, Singapore 117456, Singapore. [Stiles, Brad G.] US Army, Integrated Toxicol Div, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. [Stiles, Brad G.] Wilson Coll, Dept Biol, Chambersburg, PA 17201 USA. [Satyanarayana-Jois, Seetharama] Univ Louisiana Monroe, Dept Basic Pharmaceut Sci, Sch Pharm, Monroe, LA 71291 USA. [Chinnathambi, Arunachalam; Zayed, M. E.; Alharbi, Sulaiman Ali; Sethi, Gautam] King Saud Univ, Coll Sci, Dept Bot & Microbiol, Riyadh 11451, Saudi Arabia. [Siveen, Kodappully Sivaraman; Kumar, Alan Prem; Sethi, Gautam] NUS, Dept Pharmacol, Yong Loo Lin Sch Med, Singapore, Singapore. [Sikka, Sakshi; Kumar, Alan Prem] Canc Sci Inst Singapore, Singapore, Singapore. [Kumar, Alan Prem] Natl Univ Canc Inst, Singapore, Singapore. [Kumar, Alan Prem] Curtin Univ, Fac Hlth Sci, Sch Biomed Sci, Bentley, WA, Australia. [Kumar, Alan Prem] Univ N Texas, Dept Biol Sci, Denton, TX 76203 USA. RP Samy, RP (reprint author), Natl Univ Singapore, Dept Physiol, NUS Immunol Programme, Ctr Life Sci,Yong Loo Lin Sch Med, Singapore 117456, Singapore. EM rperumalsamy@yahoo.co.uk RI Chinnathambi, Arunachalam/E-7808-2016; OI Chinnathambi, Arunachalam/0000-0002-7126-8421; Lim, Lina/0000-0002-2935-2275 FU NUHS Bench-to- Bedside-To-Product grant [R-184-000-242-515]; Deanship of Scientific Research, College of Sciences Research Center, King Saud University, Kingdom of Saudi under The Visiting Professor Program FX This work was supported by NUHS Bench-to- Bedside-To-Product grant (R-184-000-242-515) to GS. GS will also like to thank Deanship of Scientific Research, College of Sciences Research Center, King Saud University, Kingdom of Saudi for awarding the Visiting Professorship under The Visiting Professor Program. NR 90 TC 5 Z9 5 U1 4 U2 11 PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER PI PARIS PA 23 RUE LINOIS, 75724 PARIS, FRANCE SN 0300-9084 EI 1638-6183 J9 BIOCHIMIE JI Biochimie PD APR PY 2015 VL 111 BP 30 EP 44 DI 10.1016/j.biochi.2015.01.003 PG 15 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA CG3KE UT WOS:000353178300004 PM 25583073 ER PT J AU Guevarra, CS Borke, JL Stevens, MR Bisch, FC Zakhary, I Messer, R Gerlach, RC Elsalanty, ME AF Guevarra, Chestine S. Borke, James L. Stevens, Mark R. Bisch, Fredrick C. Zakhary, Ibrahim Messer, Regina Gerlach, Robert C. Elsalanty, Mohammed E. TI Vascular Alterations in the Sprague-Dawley Rat Mandible During Intravenous Bisphosphonate Therapy SO Journal of Oral Implantology LA English DT Article DE bisphosphonate; BRONJ; vascular parameters; rat model; mandible ID SERUM CTX; ZOLEDRONIC ACID; CANCER-PATIENTS; OSTEONECROSIS; JAWS; PREVENTION; LESIONS; RISK AB Long-term use of intravenous bisphosphonates, such as zoledronic acid (zoledronate), has been linked to bisphosphonate-related osteonecrosis of the jaw (BRONJ). Invasive dental surgery seems to trigger the bone necrosis in most cases. To determine the effects of zoledronic acid on the vascular structure of the rat mandible. Extracted of the mandibular first molar in rats that received 2 IV injections of zoledronate (20 mu g/kg), 4 weeks apart. Zoledronate-treated rats (n = 18) were then compared to a control group of untreated rats (n = 18). At the fourth, eighth, and 12th week after molar extraction, 8 rat mandibles from each group were perfused with 35% radiopaque triphenylbismuth in methyl methacrylate via carotid artery perfusion. Mandibles were harvested and examined by micro-CT to assess the spatial and dimensional changes of the vasculature as a result of zoledronate treatment. The micro-CT analysis showed that zoledronic acid-treated rats had blood vessels that were thicker, less connected, and less ordered than control rats that were not exposed to zoledronic acid. This study demonstrated that treatment with zoledronic acid in rats is associated with vascular changes in alveolar bone. Further studies are underway to explore whether these vascular changes contribute to the pathogenesis of BRONJ. C1 [Guevarra, Chestine S.; Zakhary, Ibrahim; Messer, Regina; Elsalanty, Mohammed E.] Georgia Regents Univ, Dept Oral Biol, Augusta, GA 30912 USA. [Guevarra, Chestine S.; Bisch, Fredrick C.; Gerlach, Robert C.] US Army, Adv Educ Program Periodont, Ft Gordon, GA USA. [Borke, James L.] Western Univ Hlth Sci, Coll Dent Med, Pomona, CA USA. [Stevens, Mark R.] Georgia Regents Univ, Dept Oral & Maxillofacial Surg, Augusta, GA USA. RP Elsalanty, ME (reprint author), Georgia Regents Univ, Dept Oral Biol, Augusta, GA 30912 USA. EM melsalanty@gru.edu FU AO Foundation, Davos, Switzerland; American Academy of Implant Dentistry (AAID) Research Foundation, Chicago, IL; U.S. Army Advanced Education Program in Periodontics, Fort Gordon, GA FX This work was supported by the AO Foundation, Davos, Switzerland (JLB); the American Academy of Implant Dentistry (AAID) Research Foundation, Chicago, IL (JLB); and the U.S. Army Advanced Education Program in Periodontics, Fort Gordon, GA (CSG & JLB). The views expressed in this article are those of the authors and are not to be construed as official or as reflecting the views of the U.S. Army or Department of Defense. NR 22 TC 4 Z9 4 U1 2 U2 5 PU ALLEN PRESS INC PI LAWRENCE PA 810 E 10TH ST, LAWRENCE, KS 66044 USA SN 0160-6972 EI 1548-1336 J9 J ORAL IMPLANTOL JI J. Oral Implant. PD APR PY 2015 VL 41 IS 2 BP E24 EP E29 DI 10.1563/AAID-JOI-D-13-00074 PG 6 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA CG5BD UT WOS:000353303000005 PM 24295432 ER PT J AU DuMars, T Bolton, K Maleku, A Smith-Osborne, A AF DuMars, Tyler Bolton, Kristin Maleku, Arati Smith-Osborne, Alexa TI Training MSSW Students for Military Social Work Practice and Doctoral Students in Military Resilience Research SO JOURNAL OF SOCIAL WORK EDUCATION LA English DT Article ID VETERANS; CALL AB The demand for social workers with military-related practice and research experience exceeds the current supply. To advance military social work education, we developed an interlevel master's of science in social work (MSSW) field practicum and doctoral research practicum that provides military social work field experiences and contributes to doctoral education on military intervention research. Tasked with the primary responsibility of teaching complex resilience concepts to youth participants, the project challenges MSSW students to develop deep knowledge of the material. Assigned the role of project manager of an ongoing intervention study and responsible for performing multiple hands-on research tasks, the project promotes doctoral student research proficiency. Feedback from students suggests that the project supports learning outcomes and enhances motivation to engage in present and future intervention research. C1 [DuMars, Tyler] US Army, Washington, DC USA. [Bolton, Kristin] Univ N Carolina Wilmington, Wilmington, NC USA. [Maleku, Arati; Smith-Osborne, Alexa] Univ Texas Arlington, Ctr Clin Social Work, Arlington, TX 76019 USA. [Smith-Osborne, Alexa] Univ Texas Arlington, Arlington, TX 76019 USA. [Smith-Osborne, Alexa] Univ Texas Arlington, Student Vet Project, Arlington, TX 76019 USA. RP DuMars, T (reprint author), Univ Texas Arlington, Sch Social Work, 211 South Cooper St,Box 19129, Arlington, TX 76019 USA. EM tyler.d.dumars.mil@mail.mil NR 30 TC 0 Z9 0 U1 1 U2 3 PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND SN 1043-7797 EI 2163-5811 J9 J SOC WORK EDUC JI J. Soc. Work Educ. PD APR 1 PY 2015 VL 51 SU 1 SI SI BP S117 EP S127 DI 10.1080/10437797.2015.1001294 PG 11 WC Education & Educational Research; Social Work SC Education & Educational Research; Social Work GA CG7RA UT WOS:000353500900009 ER PT J AU Welch, M AF Welch, Michael TI On the Ethics of Torture SO PUNISHMENT & SOCIETY-INTERNATIONAL JOURNAL OF PENOLOGY LA English DT Book Review C1 [Welch, Michael] Rutgers State Univ, USA, New Brunswick, NJ USA. [Welch, Michael] Rutgers State Univ, Piscataway, NJ 08855 USA. RP Welch, M (reprint author), Rutgers State Univ, Piscataway, NJ 08855 USA. NR 1 TC 1 Z9 1 U1 0 U2 0 PU SAGE PUBLICATIONS LTD PI LONDON PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND SN 1462-4745 EI 1741-3095 J9 PUNISHM SOC JI Punishm. Soc. PD APR PY 2015 VL 17 IS 2 BP 261 EP 262 DI 10.1177/1462474514536370 PG 2 WC Criminology & Penology SC Criminology & Penology GA CG1OL UT WOS:000353042500007 ER PT J AU Wolf, JC Baumgartner, WA Blazer, VS Camus, AC Engelhardt, JA Fournie, JW Frasca, S Groman, DB Kent, ML Khoo, LH Law, JM Lombardini, ED Ruehl-Fehlert, C Segner, HE Smith, SA Spitsbergen, JM Weber, K Wolfe, MJ AF Wolf, Jeffrey C. Baumgartner, Wes A. Blazer, Vicki S. Camus, Alvin C. Engelhardt, Jeffery A. Fournie, John W. Frasca, Salvatore, Jr. Groman, David B. Kent, Michael L. Khoo, Lester H. Law, Jerry M. Lombardini, Eric D. Ruehl-Fehlert, Christine Segner, Helmut E. Smith, Stephen A. Spitsbergen, Jan M. Weber, Klaus Wolfe, Marilyn J. TI Nonlesions, Misdiagnoses, Missed Diagnoses, and Other Interpretive Challenges in Fish Histopathology Studies: A Guide for Investigators, Authors, Reviewers, and Readers SO TOXICOLOGIC PATHOLOGY LA English DT Article DE artifacts; diagnostic accuracy; fish histopathology; nonlesions; tissue fixation; misdiagnosis ID TROUT ONCORHYNCHUS-MYKISS; PATHOLOGY WORKING GROUP; RAINBOW-TROUT; OREOCHROMIS-NILOTICUS; NILE TILAPIA; TOXICITY; CRITERIA; LESIONS; SITE; GILLS AB Differentiating salient histopathologic changes from normal anatomic features or tissue artifacts can be decidedly challenging, especially for the novice fish pathologist. As a consequence, findings of questionable accuracy may be reported inadvertently, and the potential negative impacts of publishing inaccurate histopathologic interpretations are not always fully appreciated. The objectives of this article are to illustrate a number of specific morphologic findings in commonly examined fish tissues (e.g., gills, liver, kidney, and gonads) that are frequently either misdiagnosed or underdiagnosed, and to address related issues involving the interpretation of histopathologic data. To enhance the utility of this article as a guide, photomicrographs of normal and abnormal specimens are presented. General recommendations for generating and publishing results from histopathology studies are additionally provided. It is hoped that the furnished information will be a useful resource for manuscript generation, by helping authors, reviewers, and readers to critically assess fish histopathologic data. C1 [Wolf, Jeffrey C.; Wolfe, Marilyn J.] Expt Pathol Labs Inc, Sterling, VA USA. [Baumgartner, Wes A.] Coll Vet Med, Dept Pathobiol Populat Med, Mississippi State, MS USA. [Blazer, Vicki S.] US Geol Survey, Kearneysville, WV USA. [Camus, Alvin C.] Univ Georgia, Coll Vet Med, Dept Pathol, Athens, GA 30602 USA. [Engelhardt, Jeffery A.] Expt Pathol Labs Inc, Camarillo, CA USA. [Fournie, John W.] US EPA, Natl Hlth & Environm Effects Res Lab, Gulf Ecol Div, Gulf Breeze, FL USA. [Frasca, Salvatore, Jr.] Univ Connecticut, Dept Pathobiol & Vet Sci, Connecticut Vet Med Diagnost Lab, Storrs, CT USA. [Groman, David B.] Univ Prince Edward Isl, Atlantic Vet Coll, Aquat Diagnost Serv, Charlottetown, PE C1A 4P3, Canada. [Kent, Michael L.] Oregon State Univ, Dept Microbiol, Corvallis, OR 97331 USA. [Kent, Michael L.] Oregon State Univ, Dept Biomed Sci, Corvallis, OR 97331 USA. [Khoo, Lester H.] Mississippi State Univ, Coll Vet Med, Stoneville, MS USA. [Law, Jerry M.] N Carolina State Univ, Coll Vet Med, Aquat Ecotoxicol, Raleigh, NC USA. [Lombardini, Eric D.] Armed Forces Res Inst Med Sci, Dept Vet Med, Div Comparat Pathol, Bangkok 10400, Thailand. [Lombardini, Eric D.] Armed Forces Res Inst Med Sci, Dept Vet Med, Div Vet Med Res, Bangkok 10400, Thailand. [Ruehl-Fehlert, Christine] Bayer HealthCare, Wuppertal, Germany. [Segner, Helmut E.] Univ Bern, Ctr Fish & Wildlife Hlth, Bern, Switzerland. [Smith, Stephen A.] Virginia Tech, Virginia Maryland Reg Coll Vet Med, Blacksburg, VA USA. [Spitsbergen, Jan M.] Oregon State Univ, Dept Microbiol, Fish Dis Res Grp, Corvallis, OR 97331 USA. [Weber, Klaus] AnaPath GmbH, Oberbuchsiten, Switzerland. RP Wolf, JC (reprint author), 45600 Terminal Dr, Sterling, VA 20166 USA. EM jwolf@epl-inc.com NR 42 TC 13 Z9 13 U1 2 U2 12 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0192-6233 EI 1533-1601 J9 TOXICOL PATHOL JI Toxicol. Pathol. PD APR PY 2015 VL 43 IS 3 BP 297 EP 325 DI 10.1177/0192623314540229 PG 29 WC Pathology; Toxicology SC Pathology; Toxicology GA CG3AN UT WOS:000353148900001 PM 25112278 ER PT J AU Faran, ME Johnson, PL Ban, P Shue, T Weist, MD AF Faran, Michael E. Johnson, Patti L. Ban, Paul Shue, Tracy Weist, Mark D. TI The Evolution of a School Behavioral Health Model in the US Army SO CHILD AND ADOLESCENT PSYCHIATRIC CLINICS OF NORTH AMERICA LA English DT Article DE School behavioral health; US Army; Child and family behavioral health system; Military children ID MILITARY TREATMENT FACILITY; MENTAL-HEALTH; CHILD MALTREATMENT; DEPLOYMENT; FAMILIES; CARE; SERVICES; YOUTH AB The US Army has developed an innovative School Behavioral Health (SBH) program, part of the Child and Family Behavioral Health System, a collaborative, consultative behavioral health care model that includes SBH, standardized training of primary care providers in treatment of common behavioral health problems, use of tele-consultation/tele-behavioral health, optimizing community outreach services, and integration with other related behavioral health services. In this article, the needs of military children, adolescents, and families are reviewed, a history of this initiative is presented, key themes are discussed, and next steps in advancing this evolving, innovative system of health care featuring SBH are described. C1 [Faran, Michael E.; Johnson, Patti L.; Ban, Paul; Shue, Tracy] US Army, Med Command, Child & Family Behav Hlth Off, Tacoma, WA 98431 USA. [Weist, Mark D.] Univ S Carolina, Dept Psychol, Columbia, SC 29208 USA. RP Faran, ME (reprint author), US Army, Med Command, Child & Family Behav Hlth Off, 9913-A Madigan Annex, Tacoma, WA 98431 USA. EM michael.e.faran.civ@mail.mil NR 41 TC 1 Z9 1 U1 1 U2 2 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 1056-4993 EI 1558-0490 J9 CHILD ADOL PSYCH CL JI Child Adolesc. Psychiatr. N. Am. PD APR PY 2015 VL 24 IS 2 BP 415 EP + DI 10.1016/j.chc.2014.11.008 PG 15 WC Psychiatry SC Psychiatry GA CF6IT UT WOS:000352661100015 PM 25773333 ER PT J AU Glynn, AR Alves, DA Frick, O Erwin-Cohen, R Porter, A Norris, S Waag, D Nalca, A AF Glynn, Audrey R. Alves, Derron A. Frick, Ondraya Erwin-Cohen, Rebecca Porter, Aimee Norris, Sarah Waag, David Nalca, Aysegul TI Comparison of experimental respiratory tularemia in three nonhuman primate species SO COMPARATIVE IMMUNOLOGY MICROBIOLOGY AND INFECTIOUS DISEASES LA English DT Article DE Francisella tularensis; Tularemia; Aerosol; Inhalation; Nonhuman primate; Animal model ID FRANCISELLA-TULARENSIS; BIOLOGICAL WARFARE; MONKEYS AB Tularemia is a zoonotic disease caused by Francisella tularensis, which is transmitted to humans most commonly by contact with infected animals, tick bites, or inhalation of aerosolized bacteria. F. tularensis is highly infectious via the aerosol route; inhalation of as few as 10-50 organisms can cause pneumonic tularemia. Left untreated, the pneumonic form has more than >30% case-fatality rate but with early antibiotic intervention can be reduced to 3%. This study compared tularemia disease progression across three species of nonhuman primates [African green monkey (AGM), cynomolgus macaque (CM), and rhesus macaque (RM)] following aerosolized F. tularensis Schu S4 exposure. Groups of the animals exposed to various challenge doses were observed for clinical signs of infection and blood samples were analyzed to characterize the disease pathogenesis. Whereas the AGMs and CMs succumbed to disease following challenge doses of 40 and 32 colony forming units (CFU), respectively, the RM lethal dose was 276,667 CFU. Following all challenge doses that caused disease, the NHPs experienced weight loss, bacteremia, fever as early as 4 days post exposure, and tissue burden. Necrotizing-to-pyogranulomatous lesions were observed most commonly in the lung, lymph nodes, spleen, and bone marrow. Overall, the CM model consistently manifested pathological responses similar to those resulting from inhalation of F. tularensis in humans and thereby most closely emulates human tularemia disease. The RM model displayed a higher tolerance to infection and survived exposures of up to 15,593 CFU of aerosolized F. tularensis. Published by Elsevier Ltd. C1 [Glynn, Audrey R.; Frick, Ondraya; Erwin-Cohen, Rebecca; Porter, Aimee; Nalca, Aysegul] US Army, Ctr Aerobiol Sci, Med Res Inst Infect Dis, Frederick, MD 21702 USA. [Alves, Derron A.] US Army, Div Pathol, Med Res Inst Infect Dis, Frederick, MD 21702 USA. [Norris, Sarah] US Army, Div Biostat, Med Res Inst Infect Dis, Frederick, MD 21702 USA. [Waag, David] US Army, Bacteriol Div, Med Res Inst Infect Dis, Frederick, MD 21702 USA. RP Nalca, A (reprint author), US Army, Med Inst Infect Dis, 1425 Porter St, Frederick, MD 21702 USA. EM aysegul.nalca@us.army.mil FU Office of Biodefense, Research Resources and Translational Research (OBRRTR); USAMRIID FX This study was supported by an interagency agreement between The Office of Biodefense Research Affairs (OBRA)/National Institute of Allergy and Infectious Diseases (NIAID) (now known as Office of Biodefense, Research Resources and Translational Research (OBRRTR) and USAMRIID. NR 12 TC 3 Z9 3 U1 0 U2 4 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0147-9571 EI 1878-1667 J9 COMP IMMUNOL MICROB JI Comp. Immunol. Microbiol. Infect. Dis. PD APR PY 2015 VL 39 BP 13 EP 24 DI 10.1016/j.cimid.2015.01.003 PG 12 WC Immunology; Microbiology; Veterinary Sciences SC Immunology; Microbiology; Veterinary Sciences GA CF9VZ UT WOS:000352916600003 PM 25766142 ER PT J AU Mendoza, PA Clark, MP Mizukami, N Newman, AJ Barlage, M Gutmann, ED Rasmussen, RM Rajagopalan, B Brekke, LD Arnold, JR AF Mendoza, Pablo A. Clark, Martyn P. Mizukami, Naoki Newman, Andrew J. Barlage, Michael Gutmann, Ethan D. Rasmussen, Roy M. Rajagopalan, Balaji Brekke, Levi D. Arnold, Jeffrey R. TI Effects of Hydrologic Model Choice and Calibration on the Portrayal of Climate Change Impacts SO JOURNAL OF HYDROMETEOROLOGY LA English DT Article DE Watersheds; Climate change; Hydrologic cycle; Hydrologic models; Model comparison; Model evaluation; performance ID COLORADO RIVER-BASIN; LAND-SURFACE MODEL; WINTER PRECIPITATION; SPATIAL-RESOLUTION; CHANGE SCENARIOS; WATER-BALANCE; UNITED-STATES; NORTH-AMERICA; STREAMFLOW; RUNOFF AB The assessment of climate change impacts on water resources involves several methodological decisions, including choices of global climate models (GCMs), emission scenarios, downscaling techniques, and hydrologic modeling approaches. Among these, hydrologic model structure selection and parameter calibration are particularly relevant and usually have a strong subjective component. The goal of this research is to improve understanding of the role of these decisions on the assessment of the effects of climate change on hydrologic processes. The study is conducted in three basins located in the Colorado headwaters region, using four different hydrologic model structures [PRMS, VIC, Noah LSM, and Noah LSM with multiparameterization options (Noah-MP)]. To better understand the role of parameter estimation, model performance and projected hydrologic changes (i.e., changes in the hydrology obtained from hydrologic models due to climate change) are compared before and after calibration with the University of Arizona shuffled complex evolution (SCE-UA) algorithm. Hydrologic changes are examined via a climate change scenario where the Community Climate System Model (CCSM) change signal is used to perturb the boundary conditions of the Weather Research and Forecasting (WRF) Model configured at 4-km resolution. Substantial intermodel differences (i.e., discrepancies between hydrologic models) in the portrayal of climate change impacts on water resources are demonstrated. Specifically, intermodel differences are larger than the mean signal from the CCSM-WRF climate scenario examined, even after the calibration process. Importantly, traditional single-objective calibration techniques aimed to reduce errors in runoff simulations do not necessarily improve intermodel agreement (i.e., same outputs from different hydrologic models) in projected changes of some hydrological processes such as evapotranspiration or snowpack. C1 [Mendoza, Pablo A.; Rajagopalan, Balaji] Univ Colorado, Dept Civil Environm & Architectural Engn, Boulder, CO 80309 USA. [Mendoza, Pablo A.; Rajagopalan, Balaji] Univ Colorado, Cooperat Inst Res Environm Sci, Boulder, CO 80309 USA. [Mendoza, Pablo A.; Clark, Martyn P.; Mizukami, Naoki; Newman, Andrew J.; Barlage, Michael; Gutmann, Ethan D.; Rasmussen, Roy M.] Natl Ctr Atmospher Res, Res Applicat Lab, Boulder, CO 80307 USA. [Brekke, Levi D.] US Bur Reclamat, Denver, CO 80225 USA. [Arnold, Jeffrey R.] US Army Corps Engineers, Seattle, WA USA. RP Mendoza, PA (reprint author), Univ Colorado, Dept Civil Environm & Architectural Engn, UCB 428, Boulder, CO 80309 USA. EM pmendoza@colorado.edu RI Clark, Martyn/A-5560-2015; Rajagopalan, Balaji/A-5383-2013; Gutmann, Ethan/I-5728-2012 OI Clark, Martyn/0000-0002-2186-2625; Rajagopalan, Balaji/0000-0002-6883-7240; Gutmann, Ethan/0000-0003-4077-3430 FU Bureau of Reclamation (USBR); U.S. Army Corps of Engineers (USACE); Cooperative Institute for Research and Environmental Sciences (CIRES) FX The authors thank Kyoko Ikeda for her help with WRF reanalysis datasets. We are grateful to Marketa Elsner, Roland Viger, Adam Carheden, and Tor Mohling for their advice and assistance for setting up the models. We also thank Olda Rakovec and Mary Hill for their help with the implementation of DELSA. This study was supported through a cooperative agreement with the Bureau of Reclamation (USBR), through a contract from the U.S. Army Corps of Engineers (USACE), and through a graduate fellowship from the Cooperative Institute for Research and Environmental Sciences (CIRES). NR 79 TC 12 Z9 12 U1 8 U2 40 PU AMER METEOROLOGICAL SOC PI BOSTON PA 45 BEACON ST, BOSTON, MA 02108-3693 USA SN 1525-755X EI 1525-7541 J9 J HYDROMETEOROL JI J. Hydrometeorol. PD APR PY 2015 VL 16 IS 2 BP 762 EP 780 DI 10.1175/JHM-D-14-0104.1 PG 19 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA CF7KM UT WOS:000352735100019 ER PT J AU Boghardt, T AF Boghardt, Thomas TI Dirty Work? The Use of Nazi Informants by US Army Intelligence in Postwar Europe SO JOURNAL OF MILITARY HISTORY LA English DT Article AB After World War II ended in 1945, U.S. Army intelligence agencies, especially the Counter Intelligence Corps, recruited former Nazi officials, war crimes suspects, and war criminals to collect information on communist party and Soviet activities in Europe. While studies have examined individual cases, this article seeks to establish the historical context of the early Cold War that set the framework for this intelligence exploitation. It also weighs the intelligence value of the Army's Nazi informants and reviews recruitment by other American and Allied intelligence services. Finally, it discusses the challenges of using ethical guidelines in recruiting secret agents, during the early Cold War and beyond. C1 US Army Ctr Mil Hist, Washington, DC 20374 USA. RP Boghardt, T (reprint author), US Army Ctr Mil Hist, Washington, DC 20374 USA. NR 106 TC 0 Z9 0 U1 0 U2 1 PU SOC MILITARY HISTORY PI LEXINGTON PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA 24450-1600 USA SN 0899-3718 EI 1543-7795 J9 J MILITARY HIST JI J. Mil. Hist. PD APR PY 2015 VL 79 IS 2 BP 387 EP 422 PG 36 WC History SC History GA CF9YA UT WOS:000352922600005 ER PT J AU Donnelly, WM AF Donnelly, William M. TI "This 'Horrible Example'": An Extraordinary Case of Absent Without Leave during the Vietnam War SO JOURNAL OF MILITARY HISTORY LA English DT Article AB The decision in 1965 to expand the U.S. Army's active force without a reserve mobilization quickly generated massive organizational turbulence. In this environment one unwilling soldier found an extraordinary opportunity to slip away. C1 US Army Ctr Mil Hist, Washington, DC 20374 USA. RP Donnelly, WM (reprint author), US Army Ctr Mil Hist, Washington, DC 20374 USA. NR 22 TC 0 Z9 0 U1 0 U2 0 PU SOC MILITARY HISTORY PI LEXINGTON PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA 24450-1600 USA SN 0899-3718 EI 1543-7795 J9 J MILITARY HIST JI J. Mil. Hist. PD APR PY 2015 VL 79 IS 2 BP 457 EP 466 PG 10 WC History SC History GA CF9YA UT WOS:000352922600007 ER PT J AU Connelly, DB AF Connelly, Donald B. TI Snow & Steel: The Battle of the Bulge, 1944-45 SO JOURNAL OF MILITARY HISTORY LA English DT Book Review C1 [Connelly, Donald B.] US Army Command & Gen Staff Coll, Ft Leavenworth, KS 66027 USA. RP Connelly, DB (reprint author), US Army Command & Gen Staff Coll, Ft Leavenworth, KS 66027 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU SOC MILITARY HISTORY PI LEXINGTON PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA 24450-1600 USA SN 0899-3718 EI 1543-7795 J9 J MILITARY HIST JI J. Mil. Hist. PD APR PY 2015 VL 79 IS 2 BP 531 EP 532 PG 2 WC History SC History GA CF9YA UT WOS:000352922600049 ER PT J AU Cheppudira, B Trevino, A Petz, L Gibbons, R Clifford, J AF Cheppudira, B. Trevino, A. Petz, L. Gibbons, R. Clifford, J. TI Anti-nerve growth factor antibody alters morphine tolerance in rats with and without thermal injury SO JOURNAL OF PAIN LA English DT Meeting Abstract C1 [Cheppudira, B.; Trevino, A.; Petz, L.; Gibbons, R.; Clifford, J.] US Army Inst Surg Res, San Antonio, TX USA. NR 0 TC 0 Z9 0 U1 1 U2 2 PU CHURCHILL LIVINGSTONE PI EDINBURGH PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE, LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND SN 1526-5900 J9 J PAIN JI J. Pain PD APR PY 2015 VL 16 IS 4 SU 1 MA 333 BP S59 EP S59 PG 1 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA CF7PK UT WOS:000352748600235 ER PT J AU Clifford, J Mares, A Hansen, J Averitt, D AF Clifford, J. Mares, A. Hansen, J. Averitt, D. TI Preemptive local bupivacaine attenuates mechanical and cold allodynia in a rat model of neuropathic pain SO JOURNAL OF PAIN LA English DT Meeting Abstract C1 [Clifford, J.; Mares, A.; Hansen, J.; Averitt, D.] US Army Inst Surg Res, Ft Sam Houston, TX USA. NR 0 TC 0 Z9 0 U1 1 U2 2 PU CHURCHILL LIVINGSTONE PI EDINBURGH PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE, LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND SN 1526-5900 J9 J PAIN JI J. Pain PD APR PY 2015 VL 16 IS 4 SU 1 MA 327 BP S57 EP S57 PG 1 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA CF7PK UT WOS:000352748600229 ER PT J AU Clifford, J Salas, M McIntyre, M Wong, D AF Clifford, J. Salas, M. McIntyre, M. Wong, D. TI Tetrodotoxin attenuates thermal hyperalgesia in a rat full thickness thermal injury pain model SO JOURNAL OF PAIN LA English DT Meeting Abstract C1 [Clifford, J.; Salas, M.; McIntyre, M.; Wong, D.] US Army Inst Surg Res, San Antonio, TX USA. NR 0 TC 0 Z9 0 U1 2 U2 5 PU CHURCHILL LIVINGSTONE PI EDINBURGH PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE, LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND SN 1526-5900 J9 J PAIN JI J. Pain PD APR PY 2015 VL 16 IS 4 SU 1 MA 276 BP S45 EP S45 PG 1 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA CF7PK UT WOS:000352748600178 ER PT J AU Nyland, J McLean, S Averitt, D AF Nyland, J. McLean, S. Averitt, D. TI Combined serotonin and norepinephrine reuptake inhibition reduces the effects of stress on post-injury pain behaviors in a rat model of burn injury SO JOURNAL OF PAIN LA English DT Meeting Abstract C1 [Nyland, J.; McLean, S.; Averitt, D.] US Army Inst Surg Res, San Antonio, TX USA. RI Nyland, Jennifer/J-8329-2015 OI Nyland, Jennifer/0000-0002-4549-3617 NR 0 TC 0 Z9 0 U1 0 U2 1 PU CHURCHILL LIVINGSTONE PI EDINBURGH PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE, LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND SN 1526-5900 J9 J PAIN JI J. Pain PD APR PY 2015 VL 16 IS 4 SU 1 MA 362 BP S66 EP S66 PG 1 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA CF7PK UT WOS:000352748600264 ER PT J AU Nyland, J Escolas, S Rauschendorfer, C Aden, J Young, A Chung, K AF Nyland, J. Escolas, S. Rauschendorfer, C. Aden, J. Young, A. Chung, K. TI Preparing for disaster: analgesic needs for mass burn casualties SO JOURNAL OF PAIN LA English DT Meeting Abstract C1 [Nyland, J.; Escolas, S.; Rauschendorfer, C.; Aden, J.; Young, A.; Chung, K.] US Army Inst Surg Res, San Antonio, TX USA. RI Nyland, Jennifer/J-8329-2015 OI Nyland, Jennifer/0000-0002-4549-3617 NR 0 TC 0 Z9 0 U1 0 U2 1 PU CHURCHILL LIVINGSTONE PI EDINBURGH PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE, LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND SN 1526-5900 J9 J PAIN JI J. Pain PD APR PY 2015 VL 16 IS 4 SU 1 MA 191 BP S23 EP S23 PG 1 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA CF7PK UT WOS:000352748600093 ER PT J AU David, IN Thompson, T Wolfenstine, J Allen, JL Sakamoto, J AF David, Isabel N. Thompson, Travis Wolfenstine, Jeff Allen, Jan L. Sakamoto, Jeff TI Microstructure and Li-Ion Conductivity of Hot- Pressed Cubic Li7La3Zr2O12 SO JOURNAL OF THE AMERICAN CERAMIC SOCIETY LA English DT Article ID SODIUM BETA-ALUMINA; SOLID ELECTROLYTES; GRAIN-BOUNDARY; ENERGY-STORAGE; LITHIUM; STABILITY; CERAMICS; BATTERY; AL; TEMPERATURE AB The effect of hot-pressing temperature on the microstructure and Li-ion transport of Al-doped, cubic Li7La3Zr2O12 (LLZO) was investigated. At fixed pressure (62MPa), the relative density was 86%, 97%, and 99% when hot-pressing at 900 degrees C, 1000 degrees C, and 1100 degrees C, respectively. Electrochemical impedance spectroscopy showed that the percent grain-boundary resistance decreased with increasing hot-pressing temperature. Hot pressing at 1100 degrees C resulted in a total conductivity of 0.37mS/cm at room temperature where the grain boundaries contributed to 8% of the total resistance; one of the lowest grain-boundary resistances reported. We believe hot pressing is an appealing technique to minimize grain-boundary resistance and enable correlations between LLZO composition and bulk ionic conductivity. C1 [David, Isabel N.; Thompson, Travis; Sakamoto, Jeff] Michigan State Univ, Dept Chem Engn & Mat Sci, E Lansing, MI 48824 USA. [Wolfenstine, Jeff; Allen, Jan L.] Army Res Lab, RDRL SED C, Adelphi, MD 20783 USA. RP Sakamoto, J (reprint author), Michigan State Univ, Dept Chem Engn & Mat Sci, E Lansing, MI 48824 USA. EM jsakamot@egr.msu.edu FU Tank and Automotive Research and Development Engineering Center in Warren, MI; U.S. Army Research Office [W911NF-13-1-0475]; U.S. Army Research Laboratory (ARL) FX ID, TT, and JS would like to acknowledge the support from the Tank and Automotive Research and Development Engineering Center in Warren, MI and the U.S. Army Research Office, grant W911NF-13-1-0475. JW and JLA would like to acknowledge support of the U.S. Army Research Laboratory (ARL). NR 38 TC 11 Z9 11 U1 21 U2 85 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0002-7820 EI 1551-2916 J9 J AM CERAM SOC JI J. Am. Ceram. Soc. PD APR PY 2015 VL 98 IS 4 BP 1209 EP 1214 DI 10.1111/jace.13455 PG 6 WC Materials Science, Ceramics SC Materials Science GA CF5ZD UT WOS:000352635100028 ER PT J AU Duarte, FJ Taylor, TS AF Duarte, F. J. Taylor, Travis S. TI Quantum entanglement physics secures space-to-space interferometric communications SO LASER FOCUS WORLD LA English DT Article ID INTERFERENCE AB Interferometric optical communications can potentially lead to robust, secure, and naturally encrypted long-distance laser communications in space by taking advantage of the underlying physics of quantum entanglement. C1 [Duarte, F. J.] Interferometr Opt, Rochester, NY 14604 USA. [Duarte, F. J.] Univ New Mexico, ECE, Albuquerque, NM 87131 USA. [Taylor, Travis S.] US Army Space & Missile Def Command, Huntsville, AL USA. RP Duarte, FJ (reprint author), Interferometr Opt, Rochester, NY 14604 USA. EM opticsjournal@gmail.com NR 22 TC 2 Z9 2 U1 3 U2 5 PU PENNWELL PUBL CO PI NASHUA PA 98 SPIT BROOK RD, NASHUA, NH 03062-2801 USA SN 1043-8092 J9 LASER FOCUS WORLD JI Laser Focus World PD APR PY 2015 VL 51 IS 4 BP 54 EP 58 PG 5 WC Optics SC Optics GA CG2IZ UT WOS:000353099400016 ER PT J AU Nang, RN Monahan, F Diehl, GB French, D AF Nang, Roberto N. Monahan, Felicia Diehl, Glendon B. French, Daniel TI A Qualitative Content Analysis of Global Health Engagements in Peacekeeping and Stability Operations Institute's Stability Operations Lessons Learned and Information Management System SO MILITARY MEDICINE LA English DT Article AB Many institutions collect reports in databases to make important lessons-learned available to their members. The Uniformed Services University of the Health Sciences collaborated with the Peacekeeping and Stability Operations Institute to conduct a descriptive and qualitative analysis of global health engagements (GHEs) contained in the Stability Operations Lessons Learned and Information Management System (SOLLIMS). This study used a summative qualitative content analysis approach involving six steps: (1) a comprehensive search; (2) two-stage reading and screening process to identify first-hand, health-related records; (3) qualitative and quantitative data analysis using MAXQDA, a software program; (4) a word cloud to illustrate word frequencies and interrelationships; (5) coding of individual themes and validation of the coding scheme; and (6) identification of relationships in the data and overarching lessons-learned. The individual codes with the most number of text segments coded included: planning, personnel, interorganizational coordination, communication/information sharing, and resources/supplies. When compared to the Department of Defense's (DoD's) evolving GHE principles and capabilities, the SOLLIMS coding scheme appeared to align well with the list of GHE capabilities developed by the Department of Defense Global Health Working Group. The results of this study will inform practitioners of global health and encourage additional qualitative analysis of other lessons-learned databases. C1 [Nang, Roberto N.] Uniformed Serv Univ Hlth Sci, Dept Preventat Med & Biometr, Bethesda, MD 20814 USA. [Monahan, Felicia; Diehl, Glendon B.] Uniformed Serv Univ Hlth Sci, Ctr Disaster & Humanitarian Assistance Med, Rockville, MD 20852 USA. [French, Daniel] US Army War Coll, US Army Peacekeeping & Stabil Operat Inst, Carlisle, PA 17013 USA. RP Nang, RN (reprint author), Uniformed Serv Univ Hlth Sci, Dept Preventat Med & Biometr, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA. FU Office of the Assistant Secretary of Defense for Health Affairs FX We gratefully acknowledge the help and assistance of Dr. Gerald Quinnan (USUHS); David Mosinski (PKSOI); Emily LaMarsh and Drs. Solomon Major, Charles Beadling, Edwin Burkett (USUHS) and the Department of Defense Global Health Working Group for their permission to use their list of Global Health Engagement Capabilities. This research project was funded by the M.O.D.E.L. Grant from the Office of the Assistant Secretary of Defense for Health Affairs. NR 16 TC 1 Z9 1 U1 1 U2 7 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD APR PY 2015 VL 180 IS 4 BP 409 EP 418 DI 10.7205/MILMED-D-14-00387 PG 10 WC Medicine, General & Internal SC General & Internal Medicine GA CF6UJ UT WOS:000352691600008 PM 25826346 ER PT J AU Niles, SE Balazs, GC Cawley, C Bosse, M Mackenzie, E Li, YZ Andersen, RC AF Niles, Sarah E. Balazs, George C. Cawley, Christina Bosse, Michael Mackenzie, Ellen Li, Yaunzhang Andersen, Romney C. TI Translating Research Into Practice: Is Evidence-Based Medicine Being Practiced in Military-Relevant Orthopedic Trauma? SO MILITARY MEDICINE LA English DT Article ID OPERATION ENDURING FREEDOM; TIBIA FRACTURES; FEMORAL-NECK; AMPUTATION; INJURIES; DIAGNOSIS; OUTCOMES; WOUNDS AB Orthopedic trauma remains one of the most survivable battlefield injuries seen in modern conflicts. Translating research into practice is a critical bridge that permits surgeons to further optimize medical outcomes. Orthopedic surgeons serving in the military may treat little to no trauma in their stateside practice. In conflict zones, however, the majority of their patients will have traumatic injuries. Determining risk factors for nonevidence-based practice can help identify provider knowledge gaps, which can then be targeted before deployment. Surveys were developed which sought to identify factors contributing to continued medical education and practice, as well as scenario-based questions on military-relevant orthopedic trauma. Analysis of 188 survey respondents revealed that providers with military service and less than 10 years of practice are optimally bridging research into military-relevant orthopedic trauma practice. C1 [Niles, Sarah E.; Balazs, George C.; Andersen, Romney C.] Walter Reed Natl Mil Med Ctr, Dept Orthoped, Bethesda, MD 20889 USA. [Balazs, George C.; Andersen, Romney C.] Uniformed Serv Univ Hlth Sci, F Edward Hebert Sch Med, Bethesda, MD 20814 USA. [Cawley, Christina] Lebanon Vet Affairs Med Ctr, Lebanon, PA 17042 USA. [Bosse, Michael] Carolinas Med Ctr, Dept Orthoped Surg, Charlotte, NC 28262 USA. [Mackenzie, Ellen] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Hlth Policy & Management, Baltimore, MD 21205 USA. [Li, Yaunzhang] Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. RP Niles, SE (reprint author), Walter Reed Natl Mil Med Ctr, Dept Orthoped, 8901 Wisconsin Ave, Bethesda, MD 20889 USA. RI Balazs, George/I-3202-2016 OI Balazs, George/0000-0003-2822-2986 FU Geneva Foundation [W81XWH-08-2-0085] FX This study was funded by the Geneva Foundation (grant no. W81XWH-08-2-0085). NR 14 TC 0 Z9 0 U1 1 U2 1 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD APR PY 2015 VL 180 IS 4 BP 445 EP 453 DI 10.7205/MILMED-D-14-00296 PG 9 WC Medicine, General & Internal SC General & Internal Medicine GA CF6UJ UT WOS:000352691600012 PM 25826350 ER PT J AU Mysliwiec, V Capaldi, VF Gill, J Baxter, T O'Reilly, BM Matsangas, P Roth, BJ AF Mysliwiec, Vincent Capaldi, Vincent F., II Gill, Jessica Baxter, Tristin O'Reilly, Brian M. Matsangas, Panagiotis Roth, Bernard J. TI Adherence to Positive Airway Pressure Therapy in US Military Personnel With Sleep Apnea Improves Sleepiness, Sleep Quality, and Depressive Symptoms SO MILITARY MEDICINE LA English DT Article ID POSTTRAUMATIC-STRESS-DISORDER; MOTOR-VEHICLE COLLISIONS; TRAUMATIC BRAIN-INJURY; CPAP ADHERENCE; NASAL CPAP; DAYTIME SLEEPINESS; CONTROLLED-TRIAL; OF-LIFE; ADULTS; AFGHANISTAN AB Objectives: Obstructive sleep apnea (OSA) is frequently diagnosed in U.S. military personnel. OSA is associated with sleepiness, poor sleep quality, and service-related illnesses of insomnia, depression, post-traumatic stress disorder, and traumatic brain injury. Methods: Observational study of active duty military personnel with OSA and adherence to positive airway pressure (PAP) assessed with smart chip technology. Results: 58 men with mean age 36.2 +/- 7.7 years, mean body mass index 31.4 +/- 3.7 with mean apnea-hypopnea index (AHI) 19.1 +/- 19.0 are reported. 23 (39.7%) participants were adherent to PAP, and 35 (60.3%) were nonadherent. No significant differences in baseline demographics, apnea-hypopnea index, service-related illnesses, or clinical instrument scores. Military personnel adherent to PAP had significantly improved sleepiness (p = 0.007), sleep quality (p = 0.013), depressive symptoms (p = 0.01), energy/fatigue (p = 0.027), and emotional well-being (p = 0.024). Participants with moderate-severe OSA were more likely to be in the adherent group when compared with participants diagnosed with mild OSA. Conclusions: Military personnel with OSA have low adherence to PAP. Adherence is associated with improved depressive symptoms, sleepiness, sleep quality, energy/fatigue, emotional well-being, and social functioning. Future research should focus on interventions to improve the management of OSA in military personnel. C1 [Mysliwiec, Vincent; Baxter, Tristin; O'Reilly, Brian M.; Roth, Bernard J.] Madigan Army Med Ctr, Dept Pulm Sleep Med Crit Care, Tacoma, WA 98431 USA. [Capaldi, Vincent F., II] Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. [Gill, Jessica] NIH, Bethesda, MD 20892 USA. [Matsangas, Panagiotis] US Navy, Postgrad Sch, Dept Operat Res, Monterey, CA 93943 USA. RP Mysliwiec, V (reprint author), Madigan Army Med Ctr, Dept Pulm Sleep Med Crit Care, 9040A Fitzsimmons Ave, Tacoma, WA 98431 USA. FU Center for Neuroscience and Regenerative Medicine [60855] FX The authors thank Angela Mysliwiec, MD, Madigan Army Medical Center, for editing assistance and review of the manuscript. Dr. Angela Mysliwiec did not receive compensation for her contributions. This study was supported, in part, by grant no. 60855 from the Center for Neuroscience and Regenerative Medicine. NR 55 TC 2 Z9 2 U1 0 U2 6 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD APR PY 2015 VL 180 IS 4 BP 475 EP 482 DI 10.7205/MILMED-D-14-00197 PG 8 WC Medicine, General & Internal SC General & Internal Medicine GA CF6UJ UT WOS:000352691600016 PM 25826354 ER PT J AU Schierkolk, A AF Schierkolk, Andrea TI This Dust Was Once the Man: Commemorating the 150th Anniversary of Lincoln's Last Hours SO MILITARY MEDICINE LA English DT Editorial Material C1 US Army, Med Res & Mat Command, Natl Museum Hlth & Med, Silver Spring, MD 20910 USA. RP Schierkolk, A (reprint author), US Army, Med Res & Mat Command, Natl Museum Hlth & Med, 2500 Linden Lane, Silver Spring, MD 20910 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD APR PY 2015 VL 180 IS 4 BP 483 EP 484 DI 10.7205/MILMED-D-14-00637 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA CF6UJ UT WOS:000352691600017 PM 25826355 ER PT J AU DeLacy, BG Miller, OD Hsu, CW Zander, Z Lacey, S Yagloski, R Fountain, AW Valdes, E Anquillare, E Soljacic, M Johnson, SG Joannopoulos, JD AF DeLacy, Brendan G. Miller, Owen D. Hsu, Chia Wei Zander, Zachary Lacey, Steven Yagloski, Raymond Fountain, Augustus W. Valdes, Erica Anquillare, Emma Soljacic, Mann Johnson, Steven G. Joannopoulos, John D. TI Coherent Plasmon-Exciton Coupling in Silver Platelet-J-aggregate Nanocomposites SO NANO LETTERS LA English DT Article DE Plexcitons; plasmons; excitons; J-aggregates ID FANO RESONANCES; COMPOSITE NANOPARTICLES; INDUCED TRANSPARENCY; ABSORPTION; SYSTEMS; ENHANCEMENT; NANOPRISMS; DYNAMICS; SPECTRA; AU AB Hybrid nanostructures that couple plasmon and exciton resonances generate hybridized energy states, called plexcitons, which may result in unusual light-matter interactions. We report the formation of a transparency dip in the visible spectra of colloidal suspensions containing silver nanoplatelets and a cyanine dye, 1,1'-diethyl-2,2'-cyanine iodide (PIC). PIC was electrostatically adsorbed onto the surface of silver nanoplatelet core particles, forming an outer J-aggregate shell. This core-shell architecture provided a framework for coupling the plasmon resonance of the silver nanoplatelet core with the exciton resonance of the J-aggregate shell. The sizes and aspect ratios of the silver nanoplatelets were controlled to ensure the overlap of the plasmon and exciton resonances. As a measure of the plasmon-exciton coupling strength in the system, the experimentally observed transparency dips correspond to a Rabi splitting energy of 207 meV, among the highest reported for colloidal nanoparticles. The optical properties of the silver platelet-J-aggregate nanocomposites were supported numerically and analytically by the boundary-element method and temporal coupled-mode theory, respectively. Our theoretical predictions and experimental results confirm the presence of a transparency dip for the silver nanoplatelet core J-aggregate shell structures. Additionally, the numerical and analytical calculations indicate that the observed transparencies are dominated by the coupling of absorptive resonances, as opposed to the coupling of scattering resonances. Hence, we describe the suppressed extinction in this study as an induced transparency rather than a Fano resonance. C1 [DeLacy, Brendan G.; Zander, Zachary; Lacey, Steven; Yagloski, Raymond; Fountain, Augustus W.; Valdes, Erica] US Army Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. [Miller, Owen D.; Johnson, Steven G.] MIT, Dept Math, Cambridge, MA 02139 USA. [Hsu, Chia Wei; Anquillare, Emma; Soljacic, Mann; Joannopoulos, John D.] MIT, Dept Phys, Cambridge, MA 02139 USA. [Hsu, Chia Wei] Harvard Univ, Dept Phys, Cambridge, MA 02138 USA. RP DeLacy, BG (reprint author), US Army Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. EM brendan.g.delacy.civ@mail.mil RI Hsu, Chia Wei/G-5486-2011 OI Hsu, Chia Wei/0000-0002-9609-7155 FU Department of the Army Basic Research Program; Edgewood Chemical Biological Center; U.S. Army Research Office through the Institute for Soldier Nanotechnologies [W911NF-13-D-0001] FX This research was funded by the Department of the Army Basic Research Program and sponsored by the Edgewood Chemical Biological Center. Support was also provided by the U.S. Army Research Office through the Institute for Soldier Nanotechnologies under Contract No. W911NF-13-D-0001. NR 41 TC 22 Z9 22 U1 14 U2 80 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1530-6984 EI 1530-6992 J9 NANO LETT JI Nano Lett. PD APR PY 2015 VL 15 IS 4 BP 2588 EP 2593 DI 10.1021/acs.nanolett.5b00157 PG 6 WC Chemistry, Multidisciplinary; Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied; Physics, Condensed Matter SC Chemistry; Science & Technology - Other Topics; Materials Science; Physics GA CF7QA UT WOS:000352750200056 PM 25723653 ER PT J AU Sweeney, LM Sommerville, DR Channel, SR Sharits, BC Gargas, NM Gut, CP AF Sweeney, Lisa M. Sommerville, Douglas R. Channel, Stephen R. Sharits, Brian C. Gargas, Nathan M. Gut, Chester P., Jr. TI Evaluating the validity and applicable domain of the toxic load model: Impact of concentration vs. time profile on inhalation lethality of hydrogen cyanide SO REGULATORY TOXICOLOGY AND PHARMACOLOGY LA English DT Article DE Hydrogen cyanide; Nose-only inhalation; Acute lethality; Non-constant concentrations; Pulsed exposures; Toxic load model ID EXPOSURE; RATS; KINETICS AB The ten Berge model (or "toxic load" model) is often used to estimate the acute toxicity for varying combinations of inhaled concentration and duration. Expressed as C-n x t = toxic load (TL), TLs are assumed constant for various combinations of concentration (C) and time (t). Experimental data in a recent acute inhalation study of rats exposed to time-varying concentrations of hydrogen cyanide (HCN) supported the validity of the toxic load model except under very brief, discontinuous, high concentration exposures. In the present investigation, experiments were conducted to extend the evaluation of the applicable domain of the model for acute lethality of HCN in the rat (cumulative exposure range of 2900 11,000 ppm min). The lethality of HCN over very short (<5 min) durations of high concentrations did not conform to the toxic load model. A value of n = 1.57 was determined for uninterrupted exposures min. For 30-min exposures, the presence or absence of a gap between two exposure pulses of different concentrations, the relative duration, relative height, and the ordering of the pulses (low then high, vs. high then low) did not appear to have a meaningful impact on the toxic load required for median lethality. (C) 2015 Elsevier Inc. All rights reserved. C1 [Sweeney, Lisa M.] Henry M Jackson Fdn Adv Mil Med, Naval Med Res Unit Dayton, Wright Patterson AFB, OH 45433 USA. [Sommerville, Douglas R.] US Army, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. [Channel, Stephen R.] Leidos, Linton, IN 47441 USA. [Sharits, Brian C.; Gargas, Nathan M.; Gut, Chester P., Jr.] CAMRIS, Naval Med Res Unit Dayton, Wright Patterson AFB, OH 45433 USA. RP Sweeney, LM (reprint author), Henry M Jackson Fdn Adv Mil Med, Naval Med Res Unit Dayton, Wright Patterson AFB, OH 45433 USA. EM lisa.sweeney.3.ctr@us.af.mil FU Defense Threat Reduction Agency [H1107] FX This work was supported by the Defense Threat Reduction Agency. Dr. Sweeney, Mr. Sharits, Mr. Gargas and Mr. Gut's efforts were conducted under Work Unit Number H1107. NR 26 TC 3 Z9 3 U1 2 U2 13 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0273-2300 EI 1096-0295 J9 REGUL TOXICOL PHARM JI Regul. Toxicol. Pharmacol. PD APR PY 2015 VL 71 IS 3 BP 571 EP 584 DI 10.1016/j.yrtph.2015.02.015 PG 14 WC Medicine, Legal; Pharmacology & Pharmacy; Toxicology SC Legal Medicine; Pharmacology & Pharmacy; Toxicology GA CF8PG UT WOS:000352823800023 PM 25720732 ER PT J AU Gordon, WO Peterson, GW Durke, EM AF Gordon, Wesley O. Peterson, Gregory W. Durke, Erin M. TI Reduced Chemical Warfare Agent Sorption in Polyurethane-Painted Surfaces via Plasma-Enhanced Chemical Vapor Deposition of Perfluoroalkanes SO ACS APPLIED MATERIALS & INTERFACES LA English DT Article DE chemical warfare agent resistance; plasma treatment; paint; polyurethane ID COATINGS; FILMS AB Perfluoralkalation via plasma chemical vapor deposition has been used to improve hydrophobicity of surfaces. We have investigated this technique to improve the resistance of commercial polyurethane coatings to chemicals, such as chemical warfare agents. The reported results indicate the surface treatment minimizes the spread of agent droplets and the sorption of agent into the coating. The improvement in resistance is likely due to reduction of the coating's surface free energy via fluorine incorporation, but may also have contributing effects from surface morphology changes. The data indicates that plasma-based surface modifications may have utility in improving chemical resistance of commercial coatings. C1 [Gordon, Wesley O.; Peterson, Gregory W.] US Army Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. [Durke, Erin M.] Excet Inc, Springfield, VA 22151 USA. RP Gordon, WO (reprint author), US Army Edgewood Chem Biol Ctr, 5183 Blackhawk Rd, Aberdeen Proving Ground, MD 21010 USA. EM wesley.o.gordon.civ@mail.mil FU Joint Science and Technology Office for Chemical Biological Defense FX This work was supported by the Joint Science and Technology Office for Chemical Biological Defense. The authors also thank Prof. John Morris at Virginia Tech for collecting the SEM data, as well as Patrick Riley, Janlyn Eikenberg, and Stefanie Quinones of Leidos, Inc. for performing testing at ECBC. Matthew Shue at ECBC is also acknowledged for supporting this work. NR 15 TC 2 Z9 2 U1 2 U2 13 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1944-8244 J9 ACS APPL MATER INTER JI ACS Appl. Mater. Interfaces PD APR 1 PY 2015 VL 7 IS 12 BP 6402 EP 6405 DI 10.1021/acsami.5b00790 PG 4 WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary SC Science & Technology - Other Topics; Materials Science GA CF0PM UT WOS:000352246700006 PM 25775244 ER PT J AU Seehusen, DA Grogan, SP AF Seehusen, Dean A. Grogan, Scott P. TI Magnesium Sulfate for Prevention of Preterit Birth SO AMERICAN FAMILY PHYSICIAN LA English DT Editorial Material C1 [Seehusen, Dean A.; Grogan, Scott P.] Dwight D Eisenhower Army Med Ctr, Ft Gordon, GA 30905 USA. RP Seehusen, DA (reprint author), Dwight D Eisenhower Army Med Ctr, Ft Gordon, GA 30905 USA. NR 5 TC 0 Z9 0 U1 0 U2 0 PU AMER ACAD FAMILY PHYSICIANS PI KANSAS CITY PA 8880 WARD PARKWAY, KANSAS CITY, MO 64114-2797 USA SN 0002-838X EI 1532-0650 J9 AM FAM PHYSICIAN JI Am. Fam. Physician PD APR 1 PY 2015 VL 91 IS 7 BP 444 EP 445 PG 2 WC Primary Health Care; Medicine, General & Internal SC General & Internal Medicine GA CE8UM UT WOS:000352119600006 PM 25884743 ER PT J AU Perkins, ZB Yet, B Glasgow, S Cole, E Marsh, W Brohi, K Rasmussen, TE Tai, NRM AF Perkins, Z. B. Yet, B. Glasgow, S. Cole, E. Marsh, W. Brohi, K. Rasmussen, T. E. Tai, N. R. M. TI Meta-analysis of prognostic factors for amputation following surgical repair of lower extremity vascular trauma SO BRITISH JOURNAL OF SURGERY LA English DT Review ID POPLITEAL ARTERY TRAUMA; DAMAGE CONTROL RESUSCITATION; OPEN TIBIAL FRACTURES; LIMB SALVAGE; MANGLED EXTREMITY; KNEE DISLOCATION; NATIONAL-TRAUMA; MAJOR TRAUMA; DATA-BANK; SYSTEMATIC REVIEWS AB Background: Lower extremity vascular trauma (LEVT) is a major cause of amputation. A clear understanding of prognostic factors for amputation is important to inform surgical decision-making, patient counselling and risk stratification. The aim was to develop an understanding of prognostic factors for amputation following surgical repair of LEVT. Methods: A systematic review was conducted to identify potential prognostic factors. Bayesian meta-analysis was used to calculate an absolute (pooled proportion) and relative (pooled odds ratio, OR) measure of the amputation risk for each factor. Results: Forty-five studies, totalling 3187 discrete LEVT repairs, were included. The overall amputation rate was 10.0 (95 per cent credible interval 7.4 to 13.1) per cent. Significant prognostic factors for secondary amputation included: associated major soft tissue injury (26 versus 8 per cent for no soft tissue injury; OR 5.80), compartment syndrome (28 versus 6 per cent; OR 5.11), multiple arterial injuries (18 versus 9 per cent; OR4.85), duration of ischaemia exceeding 6 h (24 versus 5 per cent; OR4.40), associated fracture (14 versus 2 per cent; OR 4.30), mechanism of injury (blast 19 per cent, blunt 16 per cent, penetrating 5 per cent), anatomical site of injury (iliac 18 per cent, popliteal 14 per cent, tibial 10 per cent, femoral 4 per cent), age over 55 years (16 versus 9 per cent; OR 3.03) and sex (men 7 per cent versus women 8 per cent; OR 0.64). Shock and nerve or venous injuries were not significant prognostic factors for secondary amputation. Conclusion: A significant proportion of patients who undergo lower extremity vascular trauma repair will require secondary amputation. This meta-analysis describes significant prognostic factors needed to inform surgical judgement, risk assessment and patient counselling. C1 [Perkins, Z. B.; Glasgow, S.; Cole, E.; Brohi, K.; Tai, N. R. M.] Univ London, Ctr Trauma Sci, London, England. [Yet, B.; Marsh, W.] Univ London, Dept Comp Sci, London, England. [Tai, N. R. M.] Royal Ctr Def Med, Acad Dept Mil Surg & Trauma, Birmingham, W Midlands, England. [Rasmussen, T. E.] US Army Med Res & Mat Command, Ft Detrick, MD USA. RP Perkins, ZB (reprint author), Royal London Hosp, Ctr Trauma Sci, London E1 1BB, England. EM zane.perkins@nhs.net RI Marsh, David/A-3213-2016; OI Marsh, David/0000-0003-0212-6363; Perkins, Zane/0000-0003-4807-8803; Yet, Barbaros/0000-0003-4058-2677 NR 93 TC 2 Z9 2 U1 2 U2 8 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0007-1323 EI 1365-2168 J9 BRIT J SURG JI Br. J. Surg. PD APR PY 2015 VL 102 IS 5 BP 436 EP 450 DI 10.1002/bjs.9689 PG 15 WC Surgery SC Surgery GA CE9AE UT WOS:000352134800002 PM 25706113 ER PT J AU Stanley, JK Lotufo, GR Biedenbach, JM Chappell, P Gust, KA AF Stanley, Jacob K. Lotufo, Guilherme R. Biedenbach, James M. Chappell, Pornsawan Gust, Kurt A. TI TOXICITY OF THE CONVENTIONAL ENERGETICS TNT AND RDX RELATIVE TO NEW INSENSITIVE MUNITIONS CONSTITUENTS DNAN AND NTO IN RANA PIPIENS TADPOLES SO ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY LA English DT Article DE Amphibians; Munitions constituents; Aquatic toxicology; Behavioral toxicology ID COMPOUND; 2,4,6-TRINITROTOLUENE; 2,4-DINITROANISOLE AB An initiative within the US military is targeting the replacement of traditional munitions constituents with insensitive munitions to reduce risk of accidental detonation. The purpose of the present study was to comparatively assess toxicity of the traditional munitions constituents 2,4,6-trinitrotoluene (TNT) and 1,3,5-trinitroperhydro-1,3,5-triazine (RDX) with the new insensitive munitions constituents 2,4-dinitroanisole (DNAN) and 3-nitro-1,2,4-triazol-5-one (NTO). The following exposure durations were performed with Rana pipiens (leopard frog) tadpoles: TNT and DNAN, 96h and 28d; RDX, 10 d and 28d; NTO, 28 d. The 96-h 50% lethal concentration (LC50) values and 95% confidence intervals for TNT and DNAN were 4.4mg/L (4.2mg/L, 4. 7mg/L) and 24.3mg/L (21.3mg/L, 27.6mg/L), respectively. No significant impacts on survival were observed in the 10-d exposure to RDX up to 25.3mg/L. Effects on tadpole swimming distance were observed with a lowest-observed-effect concentration (LOEC) of 5.9mg/L RDX. In the 28-d exposures, the LOECs for survival for TNT, DNAN, and NTO were 0.003mg/L, 2.4mg/L, and 5.0mg/L, respectively. No significant mortality was observed in the RDX chronic 28-d exposure up to the highest treatment level tested of 28.0mg/L. Neither tadpole developmental stage nor growth was significantly affected in any of the 28-d exposures. Rana pipiens were very sensitive to chronic TNT exposure, with an LOEC 3 orders of magnitude lower than those for insensitive munitions constituents DNAN and NTO. Environ Toxicol Chem 2015;34:873-879. (c) 2015 SETAC C1 [Stanley, Jacob K.; Lotufo, Guilherme R.; Biedenbach, James M.; Gust, Kurt A.] US Army Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA. [Chappell, Pornsawan] Badger Tech Serv, Vicksburg, MS USA. RP Stanley, JK (reprint author), US Army Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA. EM jacob.k.stanley@us.army.mil FU US Army's Environmental Quality Technology Basic Research Program FX Permission was granted by the Chief of Engineers to publish this material. This work was supported by the US Army's Environmental Quality Technology Basic Research Program (E. Ferguson, Technical Director). The authors thank B. Winstead of BAE Systems for help with obtaining insensitive munitions compounds. NR 37 TC 2 Z9 2 U1 3 U2 34 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0730-7268 EI 1552-8618 J9 ENVIRON TOXICOL CHEM JI Environ. Toxicol. Chem. PD APR PY 2015 VL 34 IS 4 BP 873 EP 879 DI 10.1002/etc.2890 PG 7 WC Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA CE8NY UT WOS:000352101100024 PM 25586961 ER PT J AU Lotufo, GR Biedenbach, JM Sims, JG Chappell, P Stanley, JK Gust, KA AF Lotufo, Guilherme R. Biedenbach, James M. Sims, Jerre G. Chappell, Pornsawan Stanley, Jacob K. Gust, Kurt A. TI BIOACCUMULATION KINETICS OF THE CONVENTIONAL ENERGETICS TNT AND RDX RELATIVE TO INSENSITIVE MUNITIONS CONSTITUENTS DNAN AND NTO IN RANA PIPIENS TADPOLES SO ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY LA English DT Article DE Amphibians; Bioconcentration; Energetics; Toxicokinetics ID CATFISH ICTALURUS-PUNCTATUS; FRESH-WATER AMPHIPODS; ORGANIC-CHEMICALS; EXPLOSIVE COMPOUNDS; AQUATIC ORGANISMS; TOXICITY; 2,4,6-TRINITROTOLUENE; TOXICOKINETICS; ACCUMULATION; 2,4-DINITROANISOLE AB The manufacturing of explosives and their loading, assembling, and packing into munitions for use in testing on training sites or battlefields has resulted in contamination of terrestrial and aquatic sites that may pose risk to populations of sensitive species. The bioaccumulative potential of the conventional explosives 2,4,6-trinitrotoluene (TNT) and hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) and of the insensitive munitions (i.e., less shock sensitive) compound 2,4-dinitroanisole (DNAN) were assessed using the Northern leopard frog, Rana pipiens. Trinitrotoluene entering the organism was readily biotransformed to aminodinitrotoluenes, whereas no transformation products were measured for RDX or DNAN. Uptake clearance rates were relatively slow and similar among compounds (1.32-2.19L kg(-1) h(-1)). Upon transfer to uncontaminated water, elimination rate was very fast, resulting in the prediction of fast time to approach steady state (5h or less) and short elimination half-lives (1.2h or less). A preliminary bioconcentration factor of 0.25L kg(-1) was determined for the insensitive munitions compound 3-nitro-1,2,4-trizole-5-one (NTO) indicating negligible bioaccumulative potential. Because of the rapid elimination rate for explosives, tadpoles inhabiting contaminated areas are expected to experience harmful effects only if under constant exposure conditions given that body burdens can rapidly depurate preventing tissue concentrations from persisting at levels that may cause detrimental biological effects. Environ Toxicol Chem 2015;34:880-886. (c) 2014 SETAC C1 [Lotufo, Guilherme R.; Biedenbach, James M.; Sims, Jerre G.; Stanley, Jacob K.; Gust, Kurt A.] US Army Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. [Chappell, Pornsawan] Badger Tech Serv, San Antonio, TX USA. RP Lotufo, GR (reprint author), US Army Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. EM guilherme.lotufo@usace.army.mil FU US Army's Environmental Quality Technology Basic Research Program FX Permission was granted by the Chief of Engineers to publish this material. This work was supported by the US Army's Environmental Quality Technology Basic Research Program (E. Ferguson). The authors thank B. Winstead of BAE Systems for help with obtaining insensitive munitions compounds. NR 43 TC 1 Z9 1 U1 5 U2 30 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0730-7268 EI 1552-8618 J9 ENVIRON TOXICOL CHEM JI Environ. Toxicol. Chem. PD APR PY 2015 VL 34 IS 4 BP 880 EP 886 DI 10.1002/etc.2863 PG 7 WC Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA CE8NY UT WOS:000352101100025 PM 25524181 ER PT J AU Yaede, JR McBride, JH Nelson, ST Park, CB Flores, JA Turnbull, SJ Tingey, DG Jacobsen, RT Dong, CD Gardner, NL AF Yaede, Johnathan R. McBride, John H. Nelson, Stephen T. Park, Choon B. Flores, Joshua A. Turnbull, Stephen J. Tingey, David G. Jacobsen, Rae T. Dong, Corey D. Gardner, Nicole L. TI A geophysical strategy for measuring the thickness of the critical zone developed over basalt lavas SO GEOSPHERE LA English DT Article ID SHEAR-WAVE VELOCITY; SURFACE-WAVES; MULTICHANNEL ANALYSIS; WEATHERING RATES; HAWAII; MASW; EVOLUTION; EROSION; CLIMATE; DEPTH AB Estimates of the thickness variation in lateritic weathering profiles ( LWPs) are important in tropical areas underlain by young basalt lavas like those found in Hawaii. Seismic shear-wave velocity data were obtained by a new application of multichannel analysis of surface waves ( MASW) to map variations in the LWP and to derive the downward rate of advance of the weathering front in basaltic lavas. The MASW technique proved highly capable of imaging the internal structure and base of the critical zone, as confirmed by borehole data and direct field measurements. Profile thickness thus obtained, rapidly and without drilling, has applications to engineering and geochemical studies. The rate of advance of the weathering front derived from MASW in Oahu ranged from 0.010 m/ka to 0.026 m/ka in mesic zones (similar to 1500 mm/a rainfall), whereas an area with similar to 800 mm/a revealed rates from 0.005 m/ka to 0.011 m/ka. These rates are comparable to those derived from recent solute-based mass balance studies of ground and surface water. Conventional P-wave seismic reflection did not perform as well for detecting boundaries due to a gradational seismic velocity structure within the weathering profile. Shear-wave velocity models showed internal variations that may be caused by textural differences in parental lava flows. Limitations in imaging depth were overcome by innovative experiment designs. Increasing source-receiver offsets and merging surface-wave dispersion curves allowed for a more objective derivation of velocity-frequency relations. Further improvements were made from a recently developed form of the combined active and passive source technique. These advances allowed for more detailed and deeper imaging of the subsurface with greater confidence. Velocity models derived from MASW can thus describe the LWP in terms of depth and variability in stiffness. C1 [Yaede, Johnathan R.; McBride, John H.; Nelson, Stephen T.; Flores, Joshua A.; Tingey, David G.; Jacobsen, Rae T.; Dong, Corey D.; Gardner, Nicole L.] Brigham Young Univ, Dept Geol Sci, Provo, UT 84602 USA. [Park, Choon B.] Pk Seism LLC, Shelton, CT 06484 USA. [Turnbull, Stephen J.] US Army, Waterways Expt Stn, Coastal & Hydraul Lab Engineer & Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Yaede, JR (reprint author), Brigham Young Univ, Dept Geol Sci, Provo, UT 84602 USA. FU College of Physical and Mathematical Sciences at Brigham Young University; Landmark (Halliburton) University Grant Program FX This research was supported in part by funding from the College of Physical and Mathematical Sciences at Brigham Young University. Data processing and visualization were made possible by a generous software grant from the Landmark (Halliburton) University Grant Program. We thank Michael F. Weber and students from Brigham Young University-Hawaii for their assistance in the field work. NR 50 TC 1 Z9 1 U1 2 U2 13 PU GEOLOGICAL SOC AMER, INC PI BOULDER PA PO BOX 9140, BOULDER, CO 80301-9140 USA SN 1553-040X J9 GEOSPHERE JI Geosphere PD APR PY 2015 VL 11 IS 2 BP 514 EP 532 DI 10.1130/GES01142.1 PG 19 WC Geosciences, Multidisciplinary SC Geology GA CF0GO UT WOS:000352221400015 ER PT J AU Freese, EC Gist, NH Acitelli, RM McConnell, WJ Beck, CD Hausman, DB Murrow, JR Cureton, KJ Evans, EM AF Freese, Eric C. Gist, Nicholas H. Acitelli, Rachelle M. McConnell, Whitni J. Beck, Catherine D. Hausman, Dorothy B. Murrow, Jonathan R. Cureton, Kirk J. Evans, Ellen M. TI Acute and chronic effects of sprint interval exercise on postprandial lipemia in women at-risk for the metabolic syndrome SO JOURNAL OF APPLIED PHYSIOLOGY LA English DT Article DE triglycerides; interval exercise; meal challenge; exercise training ID LIPASE GENE-EXPRESSION; HUMAN SKELETAL-MUSCLE; HIGH-FAT MEAL; RESISTANCE EXERCISE; MODERATE EXERCISE; INTENSITY; ENDURANCE; ADAPTATIONS; MEN; TRIGLYCERIDE AB Individuals diagnosed with the metabolic syndrome (MetS) exhibit elevated postprandial lipemia (PPL). The aims of this investigation were to determine 1) if an acute bout of sprint interval training (SIT) attenuates PPL; and 2) if the attenuation of PPL following 6 wk of SIT is magnified compared with a single session of SIT prior to training in women at-risk for MetS (n = 45; 30-65 yr). Women were randomized to SIT (n = 22) or a nonexercise control (n = 23; CON) for 6 wk. Postprandial responses to a high-fat meal challenge (HFMC) were assessed in the CON group before (B-HFMC) and after (Post-HFMC) without prior exercise and in the SIT group at baseline (B-HFMC) without prior exercise, after an acute bout of SIT (four 30-s all-out sprints with 4-min recovery) prior to (Pre-HFMC), and after the 6-wk intervention (Post-HFMC). Responses to the HFMC were assessed by collecting venous blood samples in the fasted state and at 0, 30, 60, 120, and 180 min postprandial. Compared with baseline, an acute bout of SIT before (Pre-HFMC) and after the 6-wk intervention (PostHFMC) significantly attenuated fasted TG (P < 0.05; 16.6% and 12.3%, respectively) and postprandial area under the curve (13.1% and 9.7%, respectively; tAUC) TG responses. There was no difference in fasted or tAUC TG responses between Pre-HFMC and Post-HFMC. SIT is an effective mode of exercise to reduce fasted and postprandial TG concentrations in women at-risk for MetS. Six weeks of SIT does not magnify the attenuation of PPL in response to a single session of SIT. C1 [Freese, Eric C.; Gist, Nicholas H.; Acitelli, Rachelle M.; McConnell, Whitni J.; Beck, Catherine D.; Cureton, Kirk J.; Evans, Ellen M.] Univ Georgia, Dept Kinesiol, Athens, GA 30602 USA. [Gist, Nicholas H.] US Mil Acad, Dept Phys Educ, West Point, NY 10996 USA. [Hausman, Dorothy B.] Univ Georgia, Dept Foods & Nutr, Athens, GA 30602 USA. [Murrow, Jonathan R.] Univ Georgia Med Partnership, Georgia Regents Univ, Athens, GA USA. RP Freese, EC (reprint author), Univ Georgia, Ramsey Ctr, Dept Kinesiol, 330 River Rd, Athens, GA 30602 USA. EM efreese2@gmail.com FU Egg Nutrition Center FX This trial was funded by the Egg Nutrition Center. NR 43 TC 3 Z9 3 U1 0 U2 7 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 8750-7587 EI 1522-1601 J9 J APPL PHYSIOL JI J. Appl. Physiol. PD APR 1 PY 2015 VL 118 IS 7 BP 872 EP 879 DI 10.1152/japplphysiol.00380.2014 PG 8 WC Physiology; Sport Sciences SC Physiology; Sport Sciences GA CE9CM UT WOS:000352141200011 PM 25593284 ER PT J AU Feldman, J Hanrahan, BM Misra, S Fan, XZ Waits, CM Mitcheson, PD Ghodssi, R AF Feldman, Jeremy Hanrahan, Brendan Michael Misra, Saswat Fan, Xiao Zhu Waits, Christopher Mike Mitcheson, Paul D. Ghodssi, Reza TI Vibration-Based Diagnostics for Rotary MEMS SO JOURNAL OF MICROELECTROMECHANICAL SYSTEMS LA English DT Article DE Non-destructive testing; rotating machine measurement; rotating machine stability; vibration measurement ID ROLLING ELEMENT BEARINGS; BALL-BEARINGS; MODEL; DEFECTS; EROSION; IMPACT; SOUND AB This paper demonstrates the use of low-cost off-the-shelf (OTS) microelectromechanical system (MEMS) technology to perform vibration-based in situ monitoring, diagnostics, and characterization of a MEMS microball bearing supported radial air turbine platform. A multimodal software suite for platform automation and sensor monitoring is demonstrated using a three-level heuristic software suite and sensor network. The vibration diagnostic methods used in the platform have applications in rotary microsystems for the early detection of failure, fault diagnosis, and integrated diagnostic systems for feedback-based optimization to increase device performance, reliability, and operational lifetimes. The studied rotary microdevice used a dual OTS accelerometer configuration for dual range parallel redundant vibration analysis. The sensor suite has been used to monitor and detect multiple operational parameters measured optimally in time or frequency domains such as rotor instability, imbalance, wobble, and system resonance. This paper will lay the framework for active diagnostics in future MEMS devices through integrated systems. C1 [Feldman, Jeremy; Misra, Saswat; Fan, Xiao Zhu; Ghodssi, Reza] Univ Maryland, Dept Elect & Comp Engn, Syst Res Inst, College Pk, MD 20742 USA. [Hanrahan, Brendan Michael] Univ Maryland, Dept Mat Sci & Engn, College Pk, MD 20742 USA. [Waits, Christopher Mike] US Army Res Lab, Adelphi, MD 20783 USA. [Mitcheson, Paul D.] Univ London Imperial Coll Sci Technol & Med, Dept Elect & Elect Engn, London SW7 2AZ, England. RP Feldman, J (reprint author), Univ Maryland, Dept Elect & Comp Engn, Syst Res Inst, College Pk, MD 20742 USA. EM jerplane@gmail.com; brendan.m.hanrahan.ctr@mail.mil; smisra8@terpmail.umd.edu; xiaozfan@gmail.com; christopher.m.waits.civ@mail.mil; paul.mitcheson@imperial.ac.uk; ghodssi@umd.edu FU U.S. National Science Foundation [0901411] FX This work was supported by the U.S. National Science Foundation under Award 0901411. NR 33 TC 1 Z9 1 U1 3 U2 22 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1057-7157 EI 1941-0158 J9 J MICROELECTROMECH S JI J. Microelectromech. Syst. PD APR PY 2015 VL 24 IS 2 BP 289 EP 299 DI 10.1109/JMEMS.2014.2383171 PG 11 WC Engineering, Electrical & Electronic; Nanoscience & Nanotechnology; Instruments & Instrumentation; Physics, Applied SC Engineering; Science & Technology - Other Topics; Instruments & Instrumentation; Physics GA CF1BI UT WOS:000352278200007 ER PT J AU Tragord, BS Bui-Mansfield, LT Croy, T Shaffer, SW AF Tragord, Bradley S. Bui-Mansfield, Liem T. Croy, Theodore Shaffer, Scott W. TI Suprascapular Neuropathy After Distal Clavicle Resection and Coracoclavicular Ligament Reconstruction: A Resident's Case Problem SO JOURNAL OF ORTHOPAEDIC & SPORTS PHYSICAL THERAPY LA English DT Article DE acromioclavicular joint; electromyography; infraspinatus; nerve injury; scapula ID EXCISION; COMPLICATIONS; METAANALYSIS; DIAGNOSIS; ACCURACY; TEARS; MRI AB STUDY DESIGN: Resident's case problem. BACKGROUND: Acromioclavicular joint pathology is reported to be present in up to 30% of all patients complaining of shoulder dysfunction. The operative approach to treating acromioclavicular joint disease often includes a distal clavicle excision and, in circumstances of acromioclavicular joint instability, reconstruction of the coracoclavicular and/or the acromioclavicular ligament. Surgical complications for these procedures are rare, but potentially include suprascapular neuropathy secondary to the course of the suprascapular nerve posterior to the clavicle prior to entering the supraspinatus fossa. DIAGNOSIS: A 28-year-old Caucasian woman reported directly to an outpatient physical therapy clinic with a complaint of right shoulder weakness. Three years prior, the patient underwent a distal clavicle excision and coracoclavicular ligament reconstruction. A detailed examination, including diagnostic imaging, identified infraspinatus atrophy and weakness, increasing the suspicion for suprascapular nerve injury. Electromyography was ordered to confirm the clinical and imaging diagnosis of suprascapular neuropathy and to rule out other nerve lesions, especially considering the selective atrophy of the infraspinatus muscle without mechanical explanation. DISCUSSION: The clinical decision making and systematic use of diagnostic testing resulted in identifying a rare case of suprascapular neuropathy, selective to the infraspinatus, in a patient who previously underwent a distal clavicle excision and coracoclavicular ligament reconstruction. Without a spinoglenoid cyst or other suprascapular nerve lesion identified on advanced imaging, it is likely that the suprascapular neuropathy identified in this case was related to the Surgical procedure. C1 [Tragord, Bradley S.] Brooke Army Med Ctr, US Army Baylor Univ Doctoral Fellowship Orthopaed, Ft Sam Houston, TX 78234 USA. [Bui-Mansfield, Liem T.] Brooke Army Med Ctr, Uniformed Serv Univ Hlth Sci, Ft Sam Houston, TX 78234 USA. [Croy, Theodore; Shaffer, Scott W.] US Army Baylor Doctoral Program Phys Therapy, Ft Sam Houston, TX USA. RP Tragord, BS (reprint author), Brooke Army Med Ctr, Dept Rehabil, Phys Therapy Serv, Bldg 1179, Ft Sam Houston, TX 78234 USA. EM bradley.s.tragord.mil@mail.mil NR 21 TC 1 Z9 1 U1 1 U2 3 PU J O S P T, PI ALEXANDRIA PA 1111 NORTH FAIRFAX ST, STE 100, ALEXANDRIA, VA 22314-1436 USA SN 0190-6011 J9 J ORTHOP SPORT PHYS JI J. Orthop. Sports Phys. Ther. PD APR PY 2015 VL 45 IS 4 BP 299 EP 305 DI 10.2519/jospt.2015.5416 PG 7 WC Orthopedics; Rehabilitation; Sport Sciences SC Orthopedics; Rehabilitation; Sport Sciences GA CE9RE UT WOS:000352180300009 PM 25579694 ER PT J AU Beers, LR Mabry, LM Sullivan, RT AF Beers, Lauren R. Mabry, Lance M. Sullivan, Robert T. TI Osseous Fragment in a Patient With Knee Pain SO JOURNAL OF ORTHOPAEDIC & SPORTS PHYSICAL THERAPY LA English DT Editorial Material C1 [Beers, Lauren R.] US Army Baylor Univ, Doctoral Program Phys Therapy, Ft Sam Houston, TX 78234 USA. RP Beers, LR (reprint author), US Army Baylor Univ, Doctoral Program Phys Therapy, Ft Sam Houston, TX 78234 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU J O S P T, PI ALEXANDRIA PA 1111 NORTH FAIRFAX ST, STE 100, ALEXANDRIA, VA 22314-1436 USA SN 0190-6011 J9 J ORTHOP SPORT PHYS JI J. Orthop. Sports Phys. Ther. PD APR PY 2015 VL 45 IS 4 BP 323 EP 323 PG 1 WC Orthopedics; Rehabilitation; Sport Sciences SC Orthopedics; Rehabilitation; Sport Sciences GA CE9RE UT WOS:000352180300012 PM 25827125 ER PT J AU Agha, M Augustine, B Lovich, JE Delaney, D Sinervo, B Murphy, MO Ennen, JR Briggs, JR Cooper, R Price, SJ AF Agha, Mickey Augustine, Benjamin Lovich, Jeffrey E. Delaney, David Sinervo, Barry Murphy, Mason O. Ennen, Joshua R. Briggs, Jessica R. Cooper, Robert Price, Steven J. TI Using motion-sensor camera technology to infer seasonal activity and thermal niche of the desert tortoise (Gopherus agassizii) SO JOURNAL OF THERMAL BIOLOGY LA English DT Article DE Resource Selection Functions; Desert southwest; Climate change; Normal mixture models; Wildlife management ID WIND-ENERGY FACILITY; GENERALIZED ESTIMATING EQUATIONS; AKAIKES INFORMATION CRITERION; TURTLE PSEUDEMYS-SCRIPTA; BASKING BEHAVIOR; BODY-TEMPERATURE; SOUTHERN CALIFORNIA; CLIMATIC VARIATION; WILDLIFE RESEARCH; ACTIVITY PATTERNS AB Understanding the relationships between environmental variables and wildlife activity is an important part of effective management. The desert tortoise (Gopherus agassizii), an imperiled species of arid environments in the southwest US, may have increasingly restricted windows for activity due to current warming trends. In summer 2013, we deployed 48 motion sensor cameras at the entrances of tortoise burrows to investigate the effects of temperature, sex, and day of the year on the activity of desert tortoises. Using generalized estimating equations, we found that the relative probability of activity was associated with temperature (linear and quadratic), sex, and day of the year. Sex effects showed that male tortoises are generally more active than female tortoises. Temperature had a quadratic effect, indicating that tortoise activity was heightened at a range of temperatures. In addition, we found significant support for interactions between sex and day of the year, and sex and temperature as predictors of the probability of activity. Using our models, we were able to estimate air temperatures and times (days and hours) that were associated with maximum activity during the study. Because tortoise activity is constrained by environmental conditions such as temperature, it is increasingly vital to conduct studies on how tortoises vary their activity throughout the Sonoran Desert to better understand the effects of a changing climate. (C) 2015 Elsevier Ltd. All rights reserved. C1 [Agha, Mickey; Price, Steven J.] Univ Kentucky, Dept Forestry, Lexington, KY 40546 USA. [Augustine, Benjamin] Virginia Tech, Dept Fish & Wildlife Conservat, Blacksburg, VA 24061 USA. [Lovich, Jeffrey E.] US Geol Survey, Southwest Biol Sci Ctr, Flagstaff, AZ 86001 USA. [Delaney, David] US Army, Construct Engn Res Lab, Champaign, IL 61826 USA. [Sinervo, Barry; Cooper, Robert] Univ Calif Santa Cruz, Dept Ecol & Evolutionary Biol, Santa Cruz, CA 95064 USA. [Murphy, Mason O.] Univ Kentucky, Dept Biol, Lexington, KY 40546 USA. [Ennen, Joshua R.] Tennessee Aquarium Conservat Inst, Chattanooga, TN 37402 USA. [Briggs, Jessica R.] Colorado State Univ, Warner Coll Nat Resources, Ft Collins, CO 80523 USA. RP Price, SJ (reprint author), Univ Kentucky, Dept Forestry, Lexington, KY 40546 USA. EM mickey.agha@uky.edu; ben.augustine@uky.edu; jeffrey_lovich@usgs.gov; David.Delaney@usace.army.mil; lizardrps@gmail.com; mason.murphy@uky.edu; jre@tnaqua.org; jessiebriggs13@gmail.com; rdcooper408@gmail.com; steven.price@uky.edu OI Lovich, Jeffrey/0000-0002-7789-2831; Agha, Mickey/0000-0003-0961-8344 FU California Energy Commission-Public Interest Energy Research Program [500-09-020]; Bureau of Land Management; University of Kentucky - Department of Forestry; California Desert Managers Group; Desert Legacy Fund of the California Desert Research Program FX Our research at the site has been supported at various times by the California Energy Commission-Public Interest Energy Research Program (Contract # 500-09-020), the Bureau of Land Management, the University of Kentucky - Department of Forestry, the California Desert Managers Group, and the Desert Legacy Fund of the California Desert Research Program. Research was conducted under permits from the United States Fish and Wildlife Service, California Department of Fish and Wildlife, and the Bureau of Land Management. We acknowledge B. Todd of the University of California, Davis, R. Huey of the University of Washington, and anonymous peer reviewers for valuable comments and critical reading of earlier versions of the manuscript. Special thanks are given to A. Muth of the Boyd Deep Canyon Desert Research Center of the University of California, Riverside, for providing accommodations during our research. Any use of trade, product, or firm names is for descriptive purposes only and does not imply endorsement by the U.S. Government. NR 94 TC 2 Z9 2 U1 6 U2 31 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0306-4565 J9 J THERM BIOL JI J. Therm. Biol. PD APR-MAY PY 2015 VL 49-50 BP 119 EP 126 DI 10.1016/j.jtherbio.2015.02.009 PG 8 WC Biology; Zoology SC Life Sciences & Biomedicine - Other Topics; Zoology GA CE7RJ UT WOS:000352039200015 PM 25774035 ER PT J AU Hourani, L Bray, R Williams, J Wilk, J Hoge, C AF Hourani, Laurel Bray, Robert Williams, Jason Wilk, Joshua Hoge, Charles TI Gender Differences in Posttraumatic Stress Disorder and Help-Seeking in the US Army SO JOURNAL OF WOMENS HEALTH LA English DT Meeting Abstract C1 [Hourani, Laurel; Bray, Robert; Williams, Jason] RTI Int, Virginia Beach, VA USA. [Wilk, Joshua; Hoge, Charles] Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 1 U2 3 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1540-9996 EI 1931-843X J9 J WOMENS HEALTH JI J. Womens Health PD APR 1 PY 2015 VL 24 IS 4 MA P48 BP 20 EP 20 PG 1 WC Public, Environmental & Occupational Health; Medicine, General & Internal; Obstetrics & Gynecology; Women's Studies SC Public, Environmental & Occupational Health; General & Internal Medicine; Obstetrics & Gynecology; Women's Studies GA CF5YE UT WOS:000352632500049 ER PT J AU Camacho, M Teixeira, J Abdullatif, J Acevedo, JL Certal, V Capasso, R Powell, NB AF Camacho, Macario Teixeira, Jeffrey Abdullatif, Jose Acevedo, Jason L. Certal, Victor Capasso, Robson Powell, Nelson B. TI Maxillomandibular Advancement and Tracheostomy for Morbidly Obese Obstructive Sleep Apnea: A Systematic Review and Meta-analysis SO OTOLARYNGOLOGY-HEAD AND NECK SURGERY LA English DT Review DE obstructive sleep apnea; sleep apnea syndromes; tracheostomy; maxillomandibular advancement; morbid obesity ID POSITIVE AIRWAY PRESSURE; TERM-FOLLOW-UP; MAXILLOFACIAL SURGERY; SURGICAL-TREATMENT; ELECTIVE TRACHEOSTOMY; ALTERNATIVE TREATMENT; ORTHOGNATHIC SURGERY; PICKWICKIAN-SYNDROME; CONSECUTIVE PATIENTS; COMPUTED-TOMOGRAPHY AB Objective The objective of this study is to systematically review polysomnography data and sleepiness in morbidly obese (body mass index [BMI] 40 kg/m(2)) patients with obstructive sleep apnea (OSA) treated with either a maxillomandibular advancement (MMA) or a tracheostomy and to evaluate the outcomes. Data Sources MEDLINE, Scopus, Web of Science, and the Cochrane Library. Review Methods A search was performed from inception through April 8, 2014, in each database. Results Six maxillomandibular advancement studies (34 patients, age 42.42 9.13 years, mean BMI 44.88 +/- 4.28 kg/m(2)) and 6 tracheostomy studies (14 patients, age 52.21 +/- 10.40 years, mean BMI 47.93 +/- 7.55 kg/m(2)) reported individual patient data. The pre- and post-MMA means +/- SDs for apnea-hypopnea indices were 86.18 +/- 33.25/h and 9.16 +/- 7.89/h (P < .00001), and lowest oxygen saturations were 66.58% +/- 16.41% and 87.03% +/- 5.90% (P < .00001), respectively. Sleepiness following MMA decreased in all 5 patients for whom it was reported. The pre- and posttracheostomy mean +/- SD values for apnea indices were 64.43 +/- 41.35/h and 1.73 +/- 2.68/h (P = .0086), oxygen desaturation indices were 69.20 +/- 26.10/h and 41.38 +/- 36.28/h (P = .22), and lowest oxygen saturations were 55.17% +/- 16.46% and 79.83% +/- 4.36% (P = .011), respectively. Two studies reported outcomes for Epworth Sleepiness Scale for 5 patients, with mean +/- SD values of 18.80 +/- 4.02 before tracheostomy and 2.80 +/- 2.77 after tracheostomy (P = .0034). Conclusion Data for MMA and tracheostomy as treatment for morbidly obese, adult OSA patients are significantly limited. We caution surgeons about drawing definitive conclusions from these limited studies; higher level studies are needed. C1 [Camacho, Macario] Stanford Hosp & Clin, Sleep Med Div, Redwood City, CA USA. [Teixeira, Jeffrey] US Army, Dept Otolaryngol Head & Neck Surg, Walter Reed Natl Mil Med Ctr, Bethesda, MD USA. [Abdullatif, Jose] Hosp Bernardino Rivadavia, Dept Otorhinolaryngol, Buenos Aires, DF, Argentina. [Acevedo, Jason L.] US Army, Dept Otolaryngol Head & Neck Surg, Reynolds Army Community Hosp, Ft Sill, OK USA. [Certal, Victor] Hosp CUF, Sleep Med Ctr, Dept Otorhinolaryngol, Oporto, Portugal. [Certal, Victor] Univ Porto, CINTESIS Ctr Res Hlth Technol & Informat Syst, P-4100 Oporto, Portugal. [Capasso, Robson] Stanford Univ, Med Ctr, Dept Otolaryngol Head & Neck Surg, Sleep Surg Div, Stanford, CA 94305 USA. [Powell, Nelson B.] Stanford Hosp & Clin, Dept Otolaryngol Head & Neck Surg, Sleep Surg Div, Stanford, CA USA. RP Camacho, M (reprint author), US Army, Stanford Hosp & Clin, Sleep Med Div, 2nd Floor,450 Broadway St, Redwood City, CA 94063 USA. EM drcamachoent@yahoo.com RI FMUP, CINTESIS/C-6631-2014; OI FMUP, CINTESIS/0000-0001-7248-2086; Certal, Victor/0000-0002-1904-9504; Camacho, Macario/0000-0001-9200-9085 FU American Academy of Otolaryngology-Head and Neck Surgery FX The American Academy of Otolaryngology-Head and Neck Surgery provided support for this manuscript as the first author participated as an AAO-HNS Cochrane Scholar and attended the 2013 Cochrane Colloquium. NR 156 TC 6 Z9 6 U1 0 U2 7 PU SAGE PUBLICATIONS LTD PI LONDON PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND SN 0194-5998 EI 1097-6817 J9 OTOLARYNG HEAD NECK JI Otolaryngol. Head Neck Surg. PD APR PY 2015 VL 152 IS 4 BP 619 EP 630 DI 10.1177/0194599814568284 PG 12 WC Otorhinolaryngology; Surgery SC Otorhinolaryngology; Surgery GA CF5ET UT WOS:000352580000013 PM 25644497 ER PT J AU Camacho, M Kushida, CA Capasso, R AF Camacho, Macario Kushida, Clete A. Capasso, Robson TI 2-Year Sleep Surgery and Medicine Fellowships for Otolaryngologists SO OTOLARYNGOLOGY-HEAD AND NECK SURGERY LA English DT Letter C1 [Camacho, Macario] Tripler Army Med Ctr, Div Sleep Surg & Med, Otolaryngol Head & Neck Surg, Honolulu, HI 96859 USA. [Kushida, Clete A.] Stanford Hosp & Clin, Dept Psychiat, Div Sleep Med, Redwood City, CA USA. [Capasso, Robson] Stanford Univ, Med Ctr, Sleep Surg Div, Dept Otolaryngol Head & Neck Surg, Stanford, CA 94305 USA. RP Camacho, M (reprint author), Tripler Army Med Ctr, Div Sleep Surg & Med, Otolaryngol Head & Neck Surg, Honolulu, HI 96859 USA. OI Camacho, Macario/0000-0001-9200-9085 NR 1 TC 0 Z9 0 U1 0 U2 0 PU SAGE PUBLICATIONS LTD PI LONDON PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND SN 0194-5998 EI 1097-6817 J9 OTOLARYNG HEAD NECK JI Otolaryngol. Head Neck Surg. PD APR PY 2015 VL 152 IS 4 BP 766 EP 767 DI 10.1177/0194599815574258 PG 2 WC Otorhinolaryngology; Surgery SC Otorhinolaryngology; Surgery GA CF5ET UT WOS:000352580000038 PM 25833930 ER PT J AU Smith, IM Beech, ZKM Lundy, JB Bowley, DM AF Smith, Iain M. Beech, Zine K. M. Lundy, Jonathan B. Bowley, Douglas M. TI A Prospective Observational Study of Abdominal Injury Management in Contemporary Military Operations Damage Control Laparotomy Is Associated With High Survivability and Low Rates of Fecal Diversion SO ANNALS OF SURGERY LA English DT Article DE abdominal injury; anastomosis; battlefield injury; damage control laparotomy; war surgery ID COLON INJURIES; SEVERITY SCORE; IRAQI-FREEDOM; CONTROL SURGERY; CONTROL RESUSCITATION; REQUIRING RESECTION; DELAYED ANASTOMOSIS; COMBAT CASUALTIES; TRAUMA PATIENTS; PRIMARY REPAIR AB Objective: This study describes the cause, management, and outcomes of abdominal injury in a mature deployed military trauma system, with particular focus on damage control, hollow visceral injury (HVI), and stoma utilization. Background: Damage control laparotomy (DCL) is established in military and civilian practice. However, optimal management of HVI during military DCL remains controversial. Methods: We studied abdominal trauma managed over 5 months at the Joint Force Combat Support Hospital, Camp Bastion, Afghanistan (Role 3). Data included demographics, wounding mechanism, injuries sustained, prehospital times, location of first laparotomy (Role 3 or forward), use of DCL or definitive laparotomy, subsequent surgical details, resource utilization, complications, and mortality. Results: Ninety-four of 636 trauma patients (15%) underwent laparotomy. Military injury mechanisms dominated [44 gunshot wounds (47%), 44 blast (47%), and 6 blunt trauma (6%)]. Seventy-two of 94 patients (77%) underwent DCL. Four patients were palliated. Seventy of 94 (74%) sustained HVI; 44 of 70 (63%) had colonic injury. Repair or resection with anastomosis was performed in 59 of 67 therapeutically managed HVI patients (88%). Six patients were managed with fecal diversion, and 6 patients were evacuated with discontinuous bowel. Anastomotic leaks occurred in 4 of 56 HVI patients (7%) with known outcomes. Median New Injury Severity Score for DCL patients was 29 (interquartile range: 18-41) versus 19.5 (interquartile range: 12-34) for patients undergoing definitive laparotomy (P = 0.016). Overall mortality was 15 of 94 (16%). Conclusions: Damage control is now used routinely for battlefield abdominal trauma. In a well-practiced Combat Support Hospital, this strategy is associated with low mortality and infrequent fecal diversion. C1 [Smith, Iain M.] 202 Midlands Field Hosp, Birmingham, W Midlands, England. [Smith, Iain M.] NIHR Surg Reconstruct & Microbiol Res Ctr, Birmingham, W Midlands, England. [Smith, Iain M.; Bowley, Douglas M.] Royal Ctr Def Med, Birmingham, W Midlands, England. [Lundy, Jonathan B.] US Army, Inst Surg Res, Houston, TX USA. RP Bowley, DM (reprint author), Queen Elizabeth Hosp, Royal Ctr Def Med, Birmingham B15 2TH, W Midlands, England. EM doug.bowley@heartofengland.nhs.uk NR 70 TC 6 Z9 6 U1 0 U2 4 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0003-4932 EI 1528-1140 J9 ANN SURG JI Ann. Surg. PD APR PY 2015 VL 261 IS 4 BP 765 EP 773 DI 10.1097/SLA.0000000000000657 PG 9 WC Surgery SC Surgery GA CE2VV UT WOS:000351679500047 PM 24646559 ER PT J AU Luu, S Cruz-Mora, J Setlow, B Feeherry, FE Doona, CJ Setlow, P AF Luu, Stephanie Cruz-Mora, Jose Setlow, Barbara Feeherry, Florence E. Doona, Christopher J. Setlow, Peter TI The Effects of Heat Activation on Bacillus Spore Germination, with Nutrients or under High Pressure, with or without Various Germination Proteins SO APPLIED AND ENVIRONMENTAL MICROBIOLOGY LA English DT Article ID SUBTILIS SPORES; DIPICOLINIC ACID; INNER MEMBRANE; STEAROTHERMOPHILUS SPORES; THERMAL STERILIZATION; CLOSTRIDIUM-BOTULINUM; FOOD QUALITY; RECEPTORS; RESISTANCE; INACTIVATION AB Nutrient germination of spores of Bacillus species occurs through germinant receptors (GRs) in spores' inner membrane (IM) in a process stimulated by sublethal heat activation. Bacillus subtilis spores maximum germination rates via different GRs required different 75 degrees C heat activation times: 15 min for L-valine germination via the GerA GR and 4 h for germination with the L-asparagine-glucose-fructose-K+ mixture via the GerB and GerK GRs, with GerK requiring the most heat activation. In some cases, optimal heat activation decreased nutrient concentrations for half-maximal germination rates. Germination of spores via various GRs by high pressure (HP) of 150 MPa exhibited heat activation requirements similar to those of nutrient germination, and the loss of the GerD protein, required for optimal GR function, did not eliminate heat activation requirements for maximal germination rates. These results are consistent with heat activation acting primarily on GRs. However, (i) heat activation had no effects on GR or GerD protein conformation, as probed by biotinylation by an external reagent; (ii) spores prepared at low and high temperatures that affect spores' IM properties exhibited large differences in heat activation requirements for nutrient germination; and (iii) spore germination by 550 MPa of HP was also affected by heat activation, but the effects were relatively GR independent. The last results are consistent with heat activation affecting spores' IM and only indirectly affecting GRs. The 150- and 550-MPa HP germinations of Bacillus amyloliquefaciens spores, a potential surrogate for Clostridium botulinum spores in HP treatments of foods, were also stimulated by heat activation. C1 [Luu, Stephanie; Cruz-Mora, Jose; Setlow, Barbara; Setlow, Peter] UConn Hlth, Dept Mol Biol & Biophys, Farmington, CT 06030 USA. [Feeherry, Florence E.; Doona, Christopher J.] US Army, Natick Soldier RD&E Ctr, Warfighter Directorate, Natick, MA USA. RP Setlow, P (reprint author), UConn Hlth, Dept Mol Biol & Biophys, Farmington, CT 06030 USA. EM setlow@nso2.uchc.edu FU Department of Defense Multi-Disciplinary Research Initiative through the U.S. Army Research Laboratory; U.S. Army Research Office [W911NF-09-1-0286] FX This communication is based upon work supported by a Department of Defense Multi-Disciplinary Research Initiative through the U.S. Army Research Laboratory and the U.S. Army Research Office under contract number W911NF-09-1-0286. NR 59 TC 12 Z9 12 U1 1 U2 24 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0099-2240 EI 1098-5336 J9 APPL ENVIRON MICROB JI Appl. Environ. Microbiol. PD APR PY 2015 VL 81 IS 8 BP 2927 EP 2938 DI 10.1128/AEM.00193-15 PG 12 WC Biotechnology & Applied Microbiology; Microbiology SC Biotechnology & Applied Microbiology; Microbiology GA CE5BE UT WOS:000351843900029 PM 25681191 ER PT J AU Chow, BJW Small, G Yam, Y Chen, L McPherson, R Achenbach, S Al-Mallah, M Berman, DS Budoff, MJ Cademartiri, F Callister, TQ Chang, HJ Cheng, VY Chinnaiyan, K Cury, R Delago, A Dunning, A Feuchtner, G Hadamitzky, M Hausleiter, J Karlsberg, RP Kaufmann, PA Kim, YJ Leipsic, J LaBounty, T Lin, F Maffei, E Ralf, GL Shaw, LJ Villines, TC Min, JK AF Chow, Benjamin J. W. Small, Gary Yam, Yeung Chen, Li McPherson, Ruth Achenbach, Stephan Al-Mallah, Mouaz Berman, Daniel S. Budoff, Matthew J. Cademartiri, Filippo Callister, Tracy Q. Chang, Hyuk-Jae Cheng, Victor Y. Chinnaiyan, Kavitha Cury, Ricardo Delago, Augustin Dunning, Allison Feuchtner, Gundrun Hadamitzky, Martin Hausleiter, Joerg Karlsberg, Ronald P. Kaufmann, Philipp A. Kim, Yong-Jin Leipsic, Jonathon LaBounty, Troy Lin, Fay Maffei, Erica Ralf, Gilbert L. Shaw, Leslee J. Villines, Todd C. Min, James K. CA CONFIRM Investigators TI Prognostic and Therapeutic Implications of Statin and Aspirin Therapy in Individuals With Nonobstructive Coronary Artery Disease Results From the CONFIRM (Coronary CT Angiography Evaluation For Clinical Outcomes: An International Multicenter Registry) Registry SO ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY LA English DT Article DE aspirin; coronary angiography; coronary atherosclerosis; mortality; prognosis; statin ID ALL-CAUSE MORTALITY; RANDOMIZED CONTROLLED-TRIAL; BEAM COMPUTED-TOMOGRAPHY; LIFE-STYLE BEHAVIORS; HEART-DISEASE; CARDIOVASCULAR EVENTS; PRIMARY PREVENTION; HYPERTENSIVE PATIENTS; DIAGNOSTIC-ACCURACY; CHOLESTEROL LEVELS AB Objective-We sought to examine the risk of mortality associated with nonobstructive coronary artery disease (CAD) and to determine the impact of baseline statin and aspirin use on mortality. Approach and Results-Coronary computed tomographic angiography permits direct visualization of nonobstructive CAD. To date, the prognostic implications of nonobstructive CAD and the potential benefit of directing therapy based on nonobstructive CAD have not been carefully examined. A total of 27 125 consecutive patients who underwent computed tomographic angiography (12 enrolling centers and 6 countries) were prospectively entered into the COronary CT Angiography EvaluatioN For Clinical Outcomes: An InteRnational Multicenter (CONFIRM) registry. Patients, without history of previous CAD or obstructive CAD, for whom baseline statin and aspirin use was available were analyzed. Each coronary segment was classified as normal or nonobstructive CAD (1%-49% stenosis). Patients were followed up for a median of 27.2 months for all-cause mortality. The study comprised 10 418 patients (5712 normal and 4706 with nonobstructive CAD). In multivariable analyses, patients with nonobstructive CAD had a 6% (95% confidence interval, 1%-12%) higher risk of mortality for each additional segment with nonobstructive plaque (P= 0.021). Baseline statin use was associated with a reduced risk of mortality (hazard ratio, 0.44; 95% confidence interval, 0.28-0.68; P= 0.0003), a benefit that was present for individuals with nonobstructive CAD (hazard ratio, 0.32; 95% confidence interval, 0.190.55; P< 0.001) but not for those without plaque (hazard ratio, 0.66; 95% confidence interval, 0.30-1.43; P= 0.287). When stratified by National Cholesterol Education Program/Adult Treatment Program III, no mortality benefit was observed in individuals without plaque. Aspirin use was not associated with mortality benefit, irrespective of the status of plaque. Conclusions-The presence and extent of nonobstructive CAD predicted mortality. Baseline statin therapy was associated with a significant reduction in mortality for individuals with nonobstructive CAD but not for individuals without CAD. C1 [Chow, Benjamin J. W.; Small, Gary; Yam, Yeung; Chen, Li; McPherson, Ruth] Univ Ottawa, Inst Heart, Dept Med Cardiol, Ottawa, ON, Canada. [Achenbach, Stephan] Univ Erlangen Nurnberg, Dept Med, D-91054 Erlangen, Germany. [Al-Mallah, Mouaz] Wayne State Univ, Dept Med, Henry Ford Hosp, Detroit, MI 48202 USA. [Berman, Daniel S.; Cheng, Victor Y.; LaBounty, Troy] Cedars Sinai Med Ctr, Dept Imaging, Los Angeles, CA 90048 USA. [Budoff, Matthew J.] Harbor Univ Calif, Los Angeles Med Ctr, Dept Med, Los Angeles, CA USA. [Cademartiri, Filippo; Maffei, Erica] Giovanni XXIII Hosp, Dept Radiol, Monastier Di Treviso, Italy. [Cademartiri, Filippo; Maffei, Erica] Erasmus MC, Dept Radiol, Rotterdam, Netherlands. [Callister, Tracy Q.] Tennessee Heart & Vasc Inst, Hendersonville, NC USA. [Chang, Hyuk-Jae] Severance Cardiovasc Hosp, Div Cardiol, Seoul, South Korea. [Chinnaiyan, Kavitha] William Beaumont Hosp, Royal Oak, MI USA. [Cury, Ricardo] Baptist Cardiac & Vasc Inst, Miami, FL USA. [Delago, Augustin] Capitol Cardiol Associates, Albany, NY USA. [Dunning, Allison] New York Presbyterian Hosp, Dept Publ Hlth, New York, NY 10021 USA. [Lin, Fay] New York Presbyterian Hosp, Dept Med & Radiol, New York, NY 10021 USA. [Min, James K.] New York Presbyterian Hosp, Dept Radiol, New York, NY 10021 USA. Weill Cornell Med Coll, New York, NY USA. [Feuchtner, Gundrun] Med Univ Innsbruck, Dept Radiol, A-6020 Innsbruck, Austria. [Hadamitzky, Martin; Hausleiter, Joerg] Tech Univ Munich, Div Cardiol, D-80290 Munich, Germany. [Karlsberg, Ronald P.] Cardiovasc Med Grp, Los Angeles, CA USA. [Kaufmann, Philipp A.] Univ Zurich Hosp, Cardiac Imaging, CH-8091 Zurich, Switzerland. [Kim, Yong-Jin] Seoul Natl Univ Hosp, Seoul 110744, South Korea. [Leipsic, Jonathon] Univ British Columbia, Dept Med & Radiol, Vancouver, BC V5Z 1M9, Canada. [Ralf, Gilbert L.] William Beaumont Hosp, Dept Cardiol, Royal Oak, MI USA. [Shaw, Leslee J.] Emory Univ, Sch Med, Dept Med, Atlanta, GA USA. [Villines, Todd C.] Walter Reed Army Med Ctr, Dept Med, Washington, DC 20307 USA. RP Min, JK (reprint author), New York Presbyterian Hosp, Weill Cornell Med Coll, 413 E 69th St,Suite 108, New York, NY 10021 USA. EM jkm2001@med.cornell.edu RI Maffei, Erica/J-2370-2016; Cademartiri, Filippo/H-7336-2015 OI Maffei, Erica/0000-0002-0388-4433; Cademartiri, Filippo/0000-0002-0579-3279 FU Heart Lung and Blood Institute of the National Institutes of Health [1R01HL115150, R0HL118019]; Leading Foreign Research Institute, Recruitment Program through the National Research Foundation of Korea (NRF) - Ministry of Science, ICT & Future Planning (MSIP) [2012027176]; Dalio Institute of Cardiovascular Imaging; Michael Wolk Foundation FX Research reported in this publication was supported by the Heart Lung and Blood Institute of the National Institutes of Health under award numbers 1R01HL115150 and R011HL118019. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. This research was also supported by Leading Foreign Research Institute, Recruitment Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT & Future Planning (MSIP; 2012027176). This study was also funded, in part, by a generous gift from the Dalio Institute of Cardiovascular Imaging and the Michael Wolk Foundation. NR 37 TC 19 Z9 19 U1 3 U2 8 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1079-5642 EI 1524-4636 J9 ARTERIOSCL THROM VAS JI Arterioscler. Thromb. Vasc. Biol. PD APR PY 2015 VL 35 IS 4 BP 981 EP U271 DI 10.1161/ATVBAHA.114.304351 PG 12 WC Hematology; Peripheral Vascular Disease SC Hematology; Cardiovascular System & Cardiology GA CE3EQ UT WOS:000351709200030 PM 25676000 ER PT J AU Arwady, MA Bawo, L Hunter, JC Massaquoi, M Matanock, A Dahn, B Ayscue, P Nyenswah, T Forrester, JD Hensley, LE Monroe, B Schoepp, RJ Chen, TH Schaecher, KE George, T Rouse, E Schafer, IJ Pillai, SK De Cock, KM AF Arwady, M. Allison Bawo, Luke Hunter, Jennifer C. Massaquoi, Moses Matanock, Almea Dahn, Bernice Ayscue, Patrick Nyenswah, Tolbert Forrester, Joseph D. Hensley, Lisa E. Monroe, Benjamin Schoepp, Randal J. Chen, Tai-Ho Schaecher, Kurt E. George, Thomas Rouse, Edward Schafer, Ilana J. Pillai, Satish K. De Cock, Kevin M. TI Evolution of Ebola Virus Disease from Exotic Infection to Global Health Priority, Liberia, Mid-2014 SO EMERGING INFECTIOUS DISEASES LA English DT Article AB Over the span of a few weeks during July and August 2014, events in West Africa changed perceptions of Ebola virus disease (EVD) from an exotic tropical disease to a priority for global health security. We describe observations during that time of a field team from the Centers for Disease Control and Prevention and personnel of the Liberian Ministry of Health and Social Welfare. We outline the early epidemiology of EVD within Liberia, including the practical limitations on surveillance and the effect on the country's health care system, such as infections among health care workers. During this time, priorities included strengthening EVD surveillance; establishing safe settings for EVD patient care (and considering alternative isolation and care models when Ebola Treatment Units were overwhelmed); improving infection control practices; establishing an incident management system; and working with Liberian airport authorities to implement EVD screening of departing passengers. C1 [Arwady, M. Allison; Hunter, Jennifer C.; Matanock, Almea; Ayscue, Patrick; Forrester, Joseph D.; Monroe, Benjamin; Chen, Tai-Ho; George, Thomas; Rouse, Edward; Schafer, Ilana J.; Pillai, Satish K.; De Cock, Kevin M.] Ctr Dis Control & Prevent, Atlanta, GA 30329 USA. [Bawo, Luke; Massaquoi, Moses; Dahn, Bernice; Nyenswah, Tolbert] Minist Hlth & Social Welf, Monrovia, Liberia. [Hensley, Lisa E.] Natl Inst Hlth, Bethesda, MD USA. [Schoepp, Randal J.; Schaecher, Kurt E.] US Army Med Res Inst Infect Dis, Frederick, MD USA. RP Arwady, MA (reprint author), Ctr Dis Control & Prevent, 1600 Clifton Rd NE,Mailstop E92, Atlanta, GA 30329 USA. EM xdr3@cdc.gov NR 5 TC 13 Z9 14 U1 3 U2 52 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 1080-6040 EI 1080-6059 J9 EMERG INFECT DIS JI Emerg. Infect. Dis PD APR PY 2015 VL 21 IS 4 BP 578 EP 584 DI 10.3201/eid2104.141940 PG 7 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA CE2NK UT WOS:000351652100004 PM 25811176 ER PT J AU Estenoz, S Bush, E AF Estenoz, Shannon Bush, Eric TI Everglades Restoration Science and Decision-Making in the Face of Climate Change: A Management Perspective SO ENVIRONMENTAL MANAGEMENT LA English DT Article DE Everglades; Everglades restoration; Climate change; Science and decision-making; Large-scale ecosystem restoration AB Managers were invited to attend the two-day "Predicting Ecological Changes in the Florida Everglades in a Future Climate Scenario" workshop and to participate in discussion and panel sessions. This paper provides a management perspective on the technical presentations presented at the workshop, identifying information of particular interest to Everglades restoration decision-making. In addition, the paper highlights the points related to science and decision-making that emerged from the discussion sessions and provides thoughts for future discussion in a follow-up forum. Particular focus is dedicated to the importance of and challenges associated with integrating science and decision-making. In addition, the paper offers a management perspective on the uncertainties of climate science and the implications they have for influencing Everglades restoration decision-making. The authors propose that on the one hand, even given uncertainties associated with predicting the ecological response to climate change, there remains a scientific consensus that Everglades restoration is generally on the right track. On the other hand, uncertainty can be a significant barrier to climate science influencing the implementation of restoration and adaptive management programs. C1 [Estenoz, Shannon] US Dept Interior, Off Everglades Restorat Initiat, Davie, FL 33314 USA. [Bush, Eric] US Army Corps Engineers, Planning & Policy Div, Jacksonville, FL USA. RP Estenoz, S (reprint author), US Dept Interior, Off Everglades Restorat Initiat, Davie, FL 33314 USA. EM shannon_estenoz@ios.doi.gov; eric.l.bush@usace.army.mil NR 19 TC 3 Z9 3 U1 1 U2 15 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0364-152X EI 1432-1009 J9 ENVIRON MANAGE JI Environ. Manage. PD APR PY 2015 VL 55 IS 4 BP 876 EP 883 DI 10.1007/s00267-015-0452-x PG 8 WC Environmental Sciences SC Environmental Sciences & Ecology GA CE4ZD UT WOS:000351838300010 PM 25790777 ER PT J AU Cole, WC Balent, EM Masella, PC Kajiura, LN Matsumoto, KW Pierce, LM AF Cole, William C. Balent, Eric M. Masella, Pamela C. Kajiura, Lauren N. Matsumoto, Karen W. Pierce, Lisa M. TI An experimental comparison of the effects of bacterial colonization on biologic and synthetic meshes SO HERNIA LA English DT Article DE Ventral hernia; Contaminated field; Biologic mesh; Synthetic mesh; Staphylococcus aureus; Escherichia coli ID VENTRAL HERNIA REPAIR; ABDOMINAL-WALL RECONSTRUCTION; IN-VIVO; INCISIONAL HERNIA; DEFECTS; MATRIX; COLLAGEN; OUTCOMES; FIELDS AB Biologic meshes are being used with increasing frequency to repair contaminated abdominal wall defects despite high long-term recurrence and infection rates associated with their use. Recent clinical reports describing the success of lightweight, macroporous synthetic meshes in contaminated ventral hernia repairs have led some surgeons to challenge the belief that synthetics are contraindicated in contaminated fields. We aimed to determine whether a frequently used biologic mesh (Strattice(TM)) is more resistant to bacterial colonization than macroporous synthetic mesh (Parietex(TM) Progrip(TM)) after inoculation with two common pathogens. Rats (n = 48) were implanted subcutaneously with Strattice(TM) or Progrip(TM). Meshes were inoculated with sterile saline or a suspension containing 10(6) colony-forming units of Staphylococcus aureus or Escherichia coli prior to wound closure (n = 8 per subgroup). Meshes were explanted at 4 weeks and underwent microbiologic and histologic analyses. Progrip(TM) demonstrated superior bacterial clearance compared to Strattice(TM) (E. coli, 88 vs. 17 % clearance, p = 0.03; S. aureus, 75 vs. 50 %, p = 0.61; combined bacterial strains, 81 vs. 36 %, p = 0.02; respectively). In the Strattice(TM) group, severely degraded meshes were observed in 100 % of animals inoculated with E. coli (but 0 % inoculated with S. aureus). In contrast, all Progrip(TM) meshes remained intact regardless of inoculum. Scores for neovascularization were higher in the synthetic group irrespective of contamination (p < 0.05). Biologic meshes may not be more resistant to bacterial colonization than reduced-weight synthetics, and their resistance may differ in response to different pathogens. The routine use of biologics in contaminated ventral hernia repair should be questioned, particularly in the presence of E. coli. C1 [Cole, William C.; Balent, Eric M.; Masella, Pamela C.] Tripler Army Med Ctr, Dept Gen Surg, Honolulu, HI 96859 USA. [Kajiura, Lauren N.; Matsumoto, Karen W.; Pierce, Lisa M.] Tripler Army Med Ctr, Dept Clin Invest, Honolulu, HI 96859 USA. RP Pierce, LM (reprint author), Tripler Army Med Ctr, Dept Clin Invest, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM lisa.m.pierce.civ@mail.mil FU Department of Clinical Investigation at Tripler Army Medical Center FX This work was supported using internal funds from the Department of Clinical Investigation at Tripler Army Medical Center. The Strattice (TM) and Progrip (TM) mesh materials used in this study were purchased by the authors' institution. NR 27 TC 9 Z9 9 U1 1 U2 3 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1265-4906 EI 1248-9204 J9 HERNIA JI Hernia PD APR PY 2015 VL 19 IS 2 BP 197 EP 205 DI 10.1007/s10029-014-1290-0 PG 9 WC Surgery SC Surgery GA CE3BS UT WOS:000351699800005 PM 25081838 ER PT J AU Herrera, CJ Owens, GP AF Herrera, Catherine J. Owens, Gina P. TI Multicultural Personality and Posttraumatic Stress in US Service Members SO JOURNAL OF CLINICAL PSYCHOLOGY LA English DT Article DE military; posttraumatic stress disorder; multicultural personality characteristics; Iraq and Afghanistan ID MENTAL-HEALTH PROBLEMS; QUESTIONNAIRE; IRAQ; AFGHANISTAN; RESILIENCE; VALIDITY; COMBAT; PTSD; CARE AB ObjectiveModern military missions place numerous demands on service members, including tactical, personal, and cultural challenges. The purpose of this study was to explore how domains of multicultural personality (cultural empathy, open-mindedness, social initiative, emotional stability, and flexibility) and combat exposure relate to posttraumatic stress disorder (PTSD) in service members. MethodParticipants (N = 163) completed the Multicultural Personality Questionnaire, Combat Exposure Scale, and PTSD Checklist-Military as part of an online survey. The majority of participants were Caucasian (87%), mean age was 33 years, and all were deployed at least once to Iraq or Afghanistan ResultsRegression results indicated that higher levels of combat exposure and open-mindedness and lower levels of flexibility and emotional stability were significant predictors of higher PTSD severity. The interactions between combat exposure and flexibility and combat exposure and openness were also significant. ConclusionHigher levels of flexibility and emotional stability seem particularly important in their association with lower PTSD severity for service members. (C) 2014 Wiley Periodicals, Inc. C1 [Herrera, Catherine J.] JFK Special Warfare Ctr & Sch, Ft Bragg, NC USA. [Owens, Gina P.] Univ Tennessee, Knoxville, TN 37996 USA. RP Owens, GP (reprint author), Univ Tennessee, Dept Psychol, 1404 Circle Dr, Knoxville, TN 37996 USA. EM gowens4@utk.edu NR 29 TC 1 Z9 1 U1 0 U2 8 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0021-9762 EI 1097-4679 J9 J CLIN PSYCHOL JI J. Clin. Psychol. PD APR PY 2015 VL 71 IS 4 BP 323 EP 333 DI 10.1002/jclp.22138 PG 11 WC Psychology, Clinical SC Psychology GA CE2VT UT WOS:000351679300004 PM 25534149 ER PT J AU Rushing, TW Howard, IL AF Rushing, Timothy W. Howard, Isaac L. TI Prediction of soil deformation beneath temporary airfield matting systems based on full-scale testing SO JOURNAL OF TERRAMECHANICS LA English DT Article DE Airfield mat; Full-scale test; Subgrade deformation; Aluminum mat; Mat; Structural mat; Temporary pavement AB This paper presents results from full-scale evaluations of an aluminum structural mat system with regard to carrying heavy aircraft across graded, but unimproved, soil with California Bearing Ratios (CBRs) of 6, 10, 15, 25, and 100. The objective was to determine relationships among soil deformation rate, the mat's flexural modulus, the number of applied passes, and the underlying soil's CBR. Current prevailing performance prediction models for aluminum mat systems are based on full-scale tests using historic aircraft loads over soils having a CBR of 4 that were never validated for soils with higher CBR values. Full-scale test results presented herein demonstrated the inability of current models to accurately predict mat permanent deformation. Strong correlations were found between measured and predicted data across the entire spectrum of soil CBRs. These relationships can be used to noticeably improve the accuracy of performance prediction models. An empirical equation was developed to reasonably predict subgrade deformation for any number of passes and soil CBR for the loading and mat system tested. Published by Elsevier Ltd. on behalf of ISTVS. C1 [Rushing, Timothy W.] US Army ERDC, Vicksburg, MS 39180 USA. [Rushing, Timothy W.; Howard, Isaac L.] Dept Civil & Environm Engn, Mississippi State, MS 39762 USA. RP Rushing, TW (reprint author), US Army ERDC, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM Timothy.W.Rushing@usace.army.mil; ILHoward@cee.msstate.edu FU Air Force Civil Engineer Center (AFCEC); Geotechnical and Structures Laboratory, US Army ERDC FX The full-scale experiments and resulting data presented in this paper were obtained from research conducted at the US Army ERDC, Geotechnical Laboratory, Airfields and Pavements Branch with funds provided by the Air Force Civil Engineer Center (AFCEC). The sponsor determined the scope of the study but did not assist in data collection, analysis, or writing. The support of AFCEC and ERDC personnel is gratefully acknowledged. Permission to publish this work was granted by the Director, Geotechnical and Structures Laboratory, US Army ERDC. NR 22 TC 2 Z9 2 U1 2 U2 8 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0022-4898 EI 1879-1204 J9 J TERRAMECHANICS JI J. Terramech. PD APR PY 2015 VL 58 BP 1 EP 9 DI 10.1016/j.jterra.2014.12.004 PG 9 WC Engineering, Environmental SC Engineering GA CE4KT UT WOS:000351800200001 ER PT J AU Raymond, JB Jayakumar, P AF Raymond, Joseph B. Jayakumar, Paramsothy TI The shearing edge of tracked vehicle - Soil interactions in path clearing applications utilizing Multi-Body Dynamics modeling & simulation SO JOURNAL OF TERRAMECHANICS LA English DT Article DE Terramechanics; Soft-soil mobility; Coulomb soil theory; Tracked vehicle mobility; Design comparison; Terzaghi passive soil failure; Flail route clearance implement; Roller-rake route clearance implement AB Tracked vehicle soil interactions were modeled and analyzed to compare the mobility of two notional path clearing implements pushed by a tracked vehicle. This exploration assesses the capabilities and limitations of the state-of-the-art in tracked vehicle dynamics modeling and simulation over soft-soil terrain. Unique modeling and simulation methods to stretch the capability of the current state-of-the-art contribute to the overall discussion. One path clearing implement was a roller and rake combination. The other was a quickly rotating flail system that cleared a definitive path by impacting and flinging the soil away. Geotechnical forcing functions implemented Coulomb's lateral earth pressure theory and Terzaghi passive soil failure models to compute the forces at the soft-soil implement interfaces. Coulomb theory was reimagined to account for anomalies present when modeling the flail, mainly its arced motion and non-semi-infinite soil resistance zone. The path-clearing implements were simulated over discrete events and compared by means of load and acceleration time histories. The discrete events include side-slopes, grades, half-rounds, potholes, cross country terrain, and 'V' shaped ditches (V-ditch). Overall, the flail system experienced lower peak loads at the interface brackets and lower peak accelerations at the vehicle's center of gravity than the roller-rake system. Published by Elsevier Ltd. on behalf of ISTVS. C1 [Raymond, Joseph B.; Jayakumar, Paramsothy] US Army TARDEC, Warren, MI 48092 USA. RP Raymond, JB (reprint author), US Army TARDEC, Mail Stop 157,6501 E 11 Mile Rd, Warren, MI 48092 USA. EM joseph.b.raymond.civ@mail.mil NR 8 TC 1 Z9 1 U1 5 U2 18 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0022-4898 EI 1879-1204 J9 J TERRAMECHANICS JI J. Terramech. PD APR PY 2015 VL 58 BP 39 EP 50 DI 10.1016/j.jterra.2014.12.003 PG 12 WC Engineering, Environmental SC Engineering GA CE4KT UT WOS:000351800200004 ER PT J AU Diaz-Alvarez, H Picucci, JR McKenna, MH Lampo, RG AF Diaz-Alvarez, Henry Picucci, Jenifer R. McKenna, Mihan House Lampo, Richard G. TI Structural response of a recycled thermoplastic lumber bridge under civilian and military loads SO JOURNAL OF THERMOPLASTIC COMPOSITE MATERIALS LA English DT Article DE Thermoplastic bridge; recycled plastic; bridge load rating; military load classification (MLC); finite element model; bridge load test AB The U.S. Army Engineer Research and Development Center (ERDC) executed a load test and verification simulation on a novel thermoplastic composite bridge, T-8518, located on Tuckers Road in Camp Mackall, North Carolina. The bridge was made with 94% recycled plastic material, primarily recycled high-density polyethylene. An M1 Abrams battle tank and a loaded dump truck were used as a live load to determine the appropriate military load classification (MLC) and civilian load rating for the bridge superstructure. The bridge was designed to support the M1 Abrams battle tank with a gross weight of 63.5 tones to replace a dilapidated timber bridge that, because of its condition, was limited to a maximum load of 4.26 tones. A finite element analysis (FEA) of the entire superstructure based on the load test results indicated that the bridge exceeded design specifications and performed in a normal linear-elastic manner with relatively small viscoelastic responses for all loads. C1 [Diaz-Alvarez, Henry; Picucci, Jenifer R.; McKenna, Mihan House] US Army Engineer Res & Dev Ctr, Geotech & Struct Lab, Vicksburg, MS 39180 USA. [Lampo, Richard G.] US Army Engineer Res & Dev Ctr, Construct Engn Res Lab, Champaign, IL USA. RP Diaz-Alvarez, H (reprint author), US Army Engineer Res & Dev Ctr, Geotech & Struct Lab, Vicksburg, MS 39180 USA. EM henry.diaz-Alvarez@usace.army.mil NR 10 TC 2 Z9 2 U1 1 U2 4 PU SAGE PUBLICATIONS LTD PI LONDON PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND SN 0892-7057 EI 1530-7980 J9 J THERMOPLAST COMPOS JI J. Thermoplast. Compos. Mater. PD APR PY 2015 VL 28 IS 4 BP 461 EP 478 DI 10.1177/0892705713486127 PG 18 WC Materials Science, Composites SC Materials Science GA CE6KV UT WOS:000351946200002 ER PT J AU Kheirabadi, BS Valdez-Delgado, KK Terrazas, LB Miranda, N Dubick, MA AF Kheirabadi, Bijan S. Valdez-Delgado, Krystal K. Terrazas, Lrasema B. Miranda, Nahir Dubick, Michael A. TI Is limited prehospital resuscitation with plasma more beneficial than using a synthetic colloid? An experimental study in rabbits with parenchymal bleeding SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY LA English DT Article DE Prehospital resuscitation; plasma; albumin; Hextend; uncontrolled hemorrhage; rabbit ID TRAUMATIC BRAIN-INJURY; FREEZE-DRIED PLASMA; BLOOD-TRANSFUSIONS STRATEGIES; DAMAGE CONTROL RESUSCITATION; INTENSIVE-CARE-UNIT; LAST 60 YEARS; FLUID RESUSCITATION; DILUTIONAL COAGULOPATHY; INCREASING HEMORRHAGE; ALBUMIN RESUSCITATION AB BACKGROUND: Reports of survival benefits of early transfusion of plasma with red blood cells (1: 1 ratio) in trauma patients suggest that plasma may be a better fluid to replace Hextend for battlefield resuscitation. We studied possible advantages of prehospital resuscitation with plasma compared with Hextend or albumin in a model of uncontrolled hemorrhage. METHODS: Male New Zealand white rabbits (3.3 +/- 0.1 kg) were anesthetized, instrumented, and subjected to a splenic injury with uncontrolled bleeding. Ten minutes after injury (mean arterial pressure [MAP] < 40 mm Hg), the rabbits received small and equal volumes (15 mL/kg) of rabbit plasma (n = 10), Hextend (n = 10), or 5% human albumin (n = 9) or no fluid. Fluids were administered in two bolus injections (20 minutes apart) and targeted to a MAP of 65 mm Hg. Animals were monitored for 2.5 hours or until death, and their blood losses were measured. Arterial blood samples were collected at different times and analyzed for ABG, CBC, and coagulation tests. RESULTS: There were no differences in baseline measures among groups. Splenic injury caused similar hemorrhages (9.1 +/- 0.4 mL/kg at 10 minutes) and decreased MAP in all subjects. Subsequent resuscitation initiated additional bleeding. At 60 minutes after injury (20 minutes after resuscitation), longer activated partial thromboplastin time and lower fibrinogen concentrations were apparent compared with baseline values with differences among groups. Thrombelastography analysis indicated faster and stronger clot formation with plasma and albumin resuscitation than with Hextend use. Shock indices were increased in all groups, but smaller changes were measured in the albumin group. Total blood loss did not differ among resuscitated rabbits but was higher (p < 0.05) than among nonresuscitated animals. Survival rates were 11% (untreated), 40% (Hextend and plasma), and 89% (albumin, p < 0.05). CONCLUSION: Resuscitation with plasma or albumin better preserved coagulation function than did Hextend. However, despite these improvements, plasma resuscitation did not reduce blood loss or improve survival, while albumin administration seemed beneficial. Copyright (C) 2015 Wolters Kluwer Health, Inc. All rights reserved. C1 [Kheirabadi, Bijan S.; Valdez-Delgado, Krystal K.; Terrazas, Lrasema B.; Miranda, Nahir; Dubick, Michael A.] US Army Inst Surg Res, Jbsa Ft Sam Houston, TX USA. RP Kheirabadi, BS (reprint author), 3650 Chambers Pass,BHT2,Bldg 3610, Ft Sam Houston, TX 78234 USA. EM Bijan.s.kheirabadi.civ@mail.mil FU US Army Medical Research and Materiel Command FX The authors have no conflict of interest to report. The funding for this work was provided the US Army Medical Research and Materiel Command. NR 41 TC 4 Z9 4 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 2163-0755 EI 2163-0763 J9 J TRAUMA ACUTE CARE JI J. Trauma Acute Care Surg. PD APR PY 2015 VL 78 IS 4 BP 752 EP 759 DI 10.1097/TA.0000000000000591 PG 8 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA CE8EJ UT WOS:000352074000014 PM 25807404 ER PT J AU Walker, MR Babikian, S Ernest, AJ Koch, TS Lustik, MB Rooks, VJ McMann, LP AF Walker, Marc R. Babikian, Sarkis Ernest, Alexander J. Koch, Troy S. Lustik, Michael B. Rooks, Veronica J. McMann, Leah P. TI Sonographic Evaluation of Hydronephrosis in the Pediatric Population Is Well-Tempered Sonography Necessary? SO JOURNAL OF ULTRASOUND IN MEDICINE LA English DT Article DE anteroposterior diameter; hydration; pediatric ultrasound; prenatal hydronephrosis; Society for Fetal Urology grade; sonography ID URETEROPELVIC JUNCTION OBSTRUCTION; DIAGNOSTIC-ACCURACY; RENOGRAPHY; DIURESIS; CHILDREN; VOLUME AB Objectives-Standardized protocols exist for diuretic renography. There are no specific guidelines regarding hydration before renal sonography. This study assessed the importance of the hydration status by sonographic measurements of the anteroposterior diameter and its effect on Society for Fetal Urology (SFU) hydronephrosis grading. Methods-Children aged 6 weeks to 16 years (mean age, 22 months) with unilateral SFU grade 3 or 4 hydronephrosis requiring diuretic renal scintigraphy were recruited to undergo prehydration and posthydration renal sonography. Hydrated diuretic renal scintigraphy, or "well-tempered" renography, was then performed. Renal sonograms were reviewed by a blinded pediatric radiologist and pediatric urologist. Two-sided statistical tests assessed whether SFU grades and the anteroposterior diameter changed significantly after hydration. Results-Among 67 kidneys, the pediatric urologist (L.P.M.) and pediatric radiologist (V.J.R) reported no SFU grade change in 45 (67%) and 52(78%) kidneys after hydration. In kidneys that changed, the posthydration grade was more likely to be higher. This difference was statistically significant (14 of 22 and 13 of 15 differences were higher grades after hydration for L.P.M. and V.J.R., respectively; P=.06; P=.007). Most kidneys that changed-with hydration differed by only 1 SFU grade. Differences greater than 1 grade were seen in 5 control kidneys, which increased from SFU grade 0 to 2. The mean anteroposterior diameter increased significantly between prehydration and posthydration sonography for both hydronephrotic kidneys (1.46 versus 1.72 cm; P<.001) and control kidneys (0.22 versus 0.39 cm; P=.019), but did not correlate with increased SFU grades. Conclusions-Hydration does have a substantial effect on the anteroposterior diameter, but it does not correlate with a substantial effect on the SFU grade; therefore, well-tempered sonography seems unnecessary. C1 [Walker, Marc R.; Ernest, Alexander J.; McMann, Leah P.] Tripler Army Med Ctr, Dept Surg, Urol Serv, Honolulu, HI 96859 USA. [Babikian, Sarkis; Koch, Troy S.; Rooks, Veronica J.] Tripler Army Med Ctr, Pediat Radiol Serv, Dept Radiol, Honolulu, HI 96859 USA. [Lustik, Michael B.] Tripler Army Med Ctr, Dept Clin Invest, Honolulu, HI 96859 USA. RP Walker, MR (reprint author), Tripler Army Med Ctr, Dept Surg, Urol Serv, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM walkmr@gmail.com NR 14 TC 1 Z9 2 U1 1 U2 2 PU AMER INST ULTRASOUND MEDICINE PI LAUREL PA SUBSCRIPTION DEPT, 14750 SWEITZER LANE, STE 100, LAUREL, MD 20707-5906 USA SN 0278-4297 EI 1550-9613 J9 J ULTRAS MED JI J. Ultrasound Med. PD APR PY 2015 VL 34 IS 4 BP 655 EP 662 DI 10.7863/ultra.34.4.655 PG 8 WC Acoustics; Radiology, Nuclear Medicine & Medical Imaging SC Acoustics; Radiology, Nuclear Medicine & Medical Imaging GA CE9RP UT WOS:000352181400013 PM 25792581 ER PT J AU Matheny, RW Riddle-Kottke, MA Leandry, LA Lynch, CM Abdalla, MN Geddis, AV Piper, DR Zhao, JJ AF Matheny, Ronald W., Jr. Riddle-Kottke, Melissa A. Leandry, Luis A. Lynch, Christine M. Abdalla, Mary N. Geddis, Alyssa V. Piper, David R. Zhao, Jean J. TI Role of Phosphoinositide 3-OH Kinase p110 beta in Skeletal Myogenesis SO MOLECULAR AND CELLULAR BIOLOGY LA English DT Article ID MYOSIN HEAVY-CHAIN; PHOSPHATIDYLINOSITOL 3-KINASE; MUSCLE DIFFERENTIATION; METABOLIC-REGULATION; P110-ALPHA ISOFORM; GENE-TRANSCRIPTION; PI3K P110-ALPHA; SATELLITE CELLS; DRUG DISCOVERY; GROWTH AB Phosphoinositide 3-OH kinase (PI3K) regulates a number of developmental and physiologic processes in skeletal muscle; however, the contributions of individual PI3K p110 catalytic subunits to these processes are not well-defined. To address this question, we investigated the role of the 110-kDa PI3K catalytic subunit beta (p110 beta) in myogenesis and metabolism. In C2C12 cells, pharmacological inhibition of p110 beta delayed differentiation. We next generated mice with conditional deletion of p110 beta in skeletal muscle (p110 beta muscle knockout [ p110 beta-mKO] mice). While young p110 beta-mKO mice possessed a lower quadriceps mass and exhibited less strength than control littermates, no differences in muscle mass or strength were observed between genotypes in old mice. However, old p110 beta-mKO mice were less glucose tolerant than old control mice. Overexpression of p110 beta accelerated differentiation in C2C12 cells and primary human myoblasts through an Akt-dependent mechanism, while expression of kinase-inactive p110 beta had the opposite effect. p110 beta overexpression was unable to promote myoblast differentiation under conditions of p110 beta inhibition, but expression of p110 beta was able to promote differentiation under conditions of p110 beta inhibition. These findings reveal a role for p110 beta during myogenesis and demonstrate that long-term reduction of skeletal muscle p110 beta impairs whole-body glucose tolerance without affecting skeletal muscle size or strength in old mice. C1 [Matheny, Ronald W., Jr.; Riddle-Kottke, Melissa A.; Leandry, Luis A.; Lynch, Christine M.; Abdalla, Mary N.; Geddis, Alyssa V.] US Army Res Inst Environm Med, Mil Performance Div, Natick, MA 01760 USA. [Piper, David R.] Thermo Fisher Sci, Life Sci Solut, Biosci Div, Madison, WI USA. [Zhao, Jean J.] Harvard Univ, Sch Med, Dana Farber Canc Inst, Dept Canc Biol, Boston, MA 02115 USA. [Zhao, Jean J.] Harvard Univ, Sch Med, Dept Biol Chem & Mol Pharmacol, Boston, MA 02115 USA. RP Matheny, RW (reprint author), US Army Res Inst Environm Med, Mil Performance Div, Natick, MA 01760 USA. EM ronald.w.matheny.civ@mail.mil FU Research Area Directorate III; Medical Research and Materiel Command; NIH [R01 CA172461-02, U24-DK092993]; U.S. Army Research Institute of Environmental Medicine FX This work was supported by funding from Research Area Directorate III, Medical Research and Materiel Command (to R.W.M.), and by NIH grants R01 CA172461-02 (to J.J.Z.) and U24-DK092993 (University of California, Davis, Mouse Metabolic Phenotyping Center). C.M.L., A.V.G., and M.N.A. were supported by appointments to the Postgraduate Research Participation Program at the U.S. Army Research Institute of Environmental Medicine, administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the U.S. Department of Energy and the U.S. Army Medical Research and Materiel Command. NR 59 TC 6 Z9 6 U1 0 U2 6 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0270-7306 EI 1098-5549 J9 MOL CELL BIOL JI Mol. Cell. Biol. PD APR PY 2015 VL 35 IS 7 BP 1182 EP 1196 DI 10.1128/MCB.00550-14 PG 15 WC Biochemistry & Molecular Biology; Cell Biology SC Biochemistry & Molecular Biology; Cell Biology GA CE3PG UT WOS:000351739200009 PM 25605332 ER PT J AU Tritsch, AM Bland, CM Hatzigeorgiou, C Sweeney, LB Phillips, M AF Tritsch, Adam M. Bland, Christopher M. Hatzigeorgiou, Christos Sweeney, Lori B. Phillips, Michael TI A Retrospective Review of the Medical Management of Hypertension and Diabetes Mellitus Following Sleeve Gastrectomy SO OBESITY SURGERY LA English DT Article DE Sleeve gastrectomy; Hypertension; Diabetes mellitus; Obesity; Medical management ID GASTRIC BYPASS; TYPE-2; SURGERY AB Bariatric surgery is being performed with increasing frequency in the USA as a definitive treatment for morbid obesity and associated comorbidities. Management strategies of type 2 diabetes mellitus (T2DM) and hypertension (HTN) medications in sleeve gastrectomy (SG) patients postoperatively are unclear, specifically in the immediate postoperative period and 6 months following surgery. From 01 June 2010 to 30 June 2011, at a single military medical facility, a retrospective review of 88 consecutive SG patients was conducted to examine the postoperative medical management of HTN and T2DM. Patient's HTN and T2DM medication regimens were evaluated for 6 months postoperatively. Categorical data was analyzed using chi-square, and continuous data was compared using the Student t test. Statistical analyses were completed with Stata, version 12. Fifty patients were prescribed an average of 2.21 HTN medications at baseline which was reduced to an average of 1.23 (p < 0.01) medications per patient at 1 month. Twenty-four patients received an average of 1.41 oral T2DM medications with a reduction to 0.70 (p < 0.01) on average at 1 month postoperatively. Medication changes persisted throughout the 6-month follow-up. Among T2DM patients requiring insulin therapy, the mean insulin dose was 42.1 units reduced to 16.8 units immediately postoperatively (p < 0.01) which persisted at 1 month. At 6 months, the mean insulin dose was 13.3 units. Medication adjustments for HTN and T2DM made immediately in the postoperative period following SG persisted throughout the 6-month follow-up period and in some patients, required further adjustments. C1 [Tritsch, Adam M.; Bland, Christopher M.; Hatzigeorgiou, Christos; Sweeney, Lori B.; Phillips, Michael] Eisenhower Army Med Ctr, Ft Gordon, GA 30905 USA. RP Tritsch, AM (reprint author), Eisenhower Army Med Ctr, 300 Hosp Rd, Ft Gordon, GA 30905 USA. EM adam.m.tritsch.mil@mail.mil; chris.bland@us.army.mil; Christos.hatzigeorgiou.mil@mail.mil; slowdiabetes@gmail.com; michael.d.phillips182.mil@mail.mil NR 11 TC 4 Z9 5 U1 1 U2 37 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0960-8923 EI 1708-0428 J9 OBES SURG JI Obes. Surg. PD APR PY 2015 VL 25 IS 4 BP 642 EP 647 DI 10.1007/s11695-014-1375-y PG 6 WC Surgery SC Surgery GA CE4AD UT WOS:000351771500007 PM 25656260 ER PT J AU Kragh, JF Dubick, MA Aden, JK McKeague, AL Rasmussen, TE Baer, DG Blackbourne, LH AF Kragh, John F., Jr. Dubick, Michael A. Aden, James K. McKeague, Anne L. Rasmussen, Todd E. Baer, David G. Blackbourne, Lorne H. TI US MILITARY USE OF TOURNIQUETS FROM 2001 TO 2010 SO PREHOSPITAL EMERGENCY CARE LA English DT Article DE emergency medical services; resuscitation; shock; first aid; medical device ID MAJOR LIMB TRAUMA; WAR AB Objective. This study was conducted to associate tourniquet use and survival in casualty care over a decade of war in order to provide evidence to emergency medical personnel for the implementation and efficacy of tourniquet use in a large trauma system. Methods. This survey is a retrospective review of data extracted from a trauma registry. The decade (2001-2010) outcome trend analysis of tourniquet use in the current wars was made in order to associate tourniquet use and survival in an observational cohort design. Results. Of 4,297 casualties with extremity trauma in the total study, 30% (1,272/4,297) had tourniquet use and 70% (3,025/4,297) did not. For all 4,297 casualties, the proportion of casualties with severe or critical extremity Abbreviated Injury Scales (AIS) increased during the years surveyed (p < 0.0001); the mean annual Injury Severity Score (ISS) rose from 13 to 21. Tourniquet use increased during the decade by almost tenfold from 4 to nearly 40% (p < 0.0001). Survival for casualties with isolated extremity injury varied by injury severity; the survival rate for AIS 3 (serious) was 98%, the rate for AIS 4 (severe) was 76%, and the rate for AIS 5 (critical) was 0%. Survival rates increased for casualties with injuries amenable to tourniquets but decreased for extremity injuries too proximal for tourniquets. Conclusions. Average injury severity increased during the decade of war for casualties with extremity injury. Both tourniquet use rates and casualty survival rates rose when injuries were amenable to tourniquets. C1 [Kragh, John F., Jr.; Aden, James K.; Baer, David G.] USAISR, Ft Sam Houston, TX 78234 USA. [Kragh, John F., Jr.] Uniformed Serv Univ Hlth Sci, F Edward Hebert Sch Med, Bethesda, MD 20814 USA. [Dubick, Michael A.] USAISR, ATTN MCMR USZ, Damage Control Resuscitat, Ft Sam Houston, TX 78234 USA. RP Kragh, JF (reprint author), US Army, Inst Surg Res, Damage Control Resuscitat, 3650 Chambers Pass,Bldg BHT2 Room 222-4, Ft Sam Houston, TX 78234 USA. EM john.f.kragh.civ@mail.mil; michael.a.dubick.civ@mail.mil; James.k.aden2.civ@mail.mil; todd.e.rasmussen.mil@mail.mil; david.g.baer.civ@mail.mil; lorne.h.blackbourne.mil@mail.mil FU USAISR funds; Defense Health Program [201105] FX This project was funded with internal USAISR funds, and the Defense Health Program (Proposal 201105: Operational system management and post-market surveillance of hemorrhage control devices used in medical care of U.S. servicepersons in the current war). NR 9 TC 6 Z9 6 U1 0 U2 1 PU INFORMA HEALTHCARE PI LONDON PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND SN 1090-3127 EI 1545-0066 J9 PREHOSP EMERG CARE JI Prehosp. Emerg. Care PD APR-JUN PY 2015 VL 19 IS 2 BP 184 EP 190 DI 10.3109/10903127.2014.964892 PG 7 WC Emergency Medicine; Public, Environmental & Occupational Health SC Emergency Medicine; Public, Environmental & Occupational Health GA CE6LS UT WOS:000351948500002 PM 25420089 ER PT J AU Clinton, TR Weinstock, MT Jacobsen, MT Szabo-Fresnais, N Pandya, MJ Whitby, FG Herbert, AS Prugar, LI McKinnon, R Hill, CP Welch, BD Dye, JM Eckert, DM Kay, MS AF Clinton, Tracy R. Weinstock, Matthew T. Jacobsen, Michael T. Szabo-Fresnais, Nicolas Pandya, Maya J. Whitby, Frank G. Herbert, Andrew S. Prugar, Laura I. McKinnon, Rena Hill, Christopher P. Welch, Brett D. Dye, John M. Eckert, Debra M. Kay, Michael S. TI Design and characterization of ebolavirus GP prehairpin intermediate mimics as drug targets SO PROTEIN SCIENCE LA English DT Article DE ebolavirus; filovirus entry; ebolavirus GP2; prehairpin intermediate; designed coiled coil; N-trimer; phage display; mirror-image phage display ID IMMUNODEFICIENCY-VIRUS TYPE-1; D-PEPTIDE INHIBITORS; HUMAN MONOCLONAL-ANTIBODY; VIRAL MEMBRANE-FUSION; NIEMANN-PICK C1; HIV-1 GP41; ENVELOPE GLYCOPROTEIN; COILED-COIL; POSTEXPOSURE PROTECTION; NONHUMAN-PRIMATES AB Ebolaviruses are highly lethal filoviruses that cause hemorrhagic fever in humans and nonhuman primates. With no approved treatments or preventatives, the development of an anti-ebolavirus therapy to protect against natural infections and potential weaponization is an urgent global health need. Here, we describe the design, biophysical characterization, and validation of peptide mimics of the ebolavirus N-trimer, a highly conserved region of the GP2 fusion protein, to be used as targets to develop broad-spectrum inhibitors of ebolavirus entry. The N-trimer region of GP2 is 90% identical across all ebolavirus species and forms a critical part of the prehairpin intermediate that is exposed during viral entry. Specifically, we fused designed coiled coils to the N-trimer to present it as a soluble trimeric coiled coil as it appears during membrane fusion. Circular dichroism, sedimentation equilibrium, and X-ray crystallography analyses reveal the helical, trimeric structure of the designed N-trimer mimic targets. Surface plasmon resonance studies validate that the N-trimer mimic binds its native ligand, the C-peptide region of GP2. The longest N-trimer mimic also inhibits virus entry, thereby confirming binding of the C-peptide region during viral entry and the presence of a vulnerable prehairpin intermediate. Using phage display as a model system, we validate the suitability of the N-trimer mimics as drug screening targets. Finally, we describe the foundational work to use the N-trimer mimics as targets in mirror-image phage display, which will be used to identify D-peptide inhibitors of ebolavirus entry. PDB Code(s): C1 [Clinton, Tracy R.; Weinstock, Matthew T.; Jacobsen, Michael T.; Szabo-Fresnais, Nicolas; Pandya, Maya J.; Whitby, Frank G.; Hill, Christopher P.; Eckert, Debra M.; Kay, Michael S.] Univ Utah, Sch Med, Dept Biochem, Salt Lake City, UT 84112 USA. [Szabo-Fresnais, Nicolas] Univ Utah, Sch Med, Dept Internal Med, Cardiol Sect, Salt Lake City, UT 84112 USA. [Herbert, Andrew S.; Prugar, Laura I.; Dye, John M.] US Army, Med Res Inst Infect Dis, Frederick, MD 21702 USA. [McKinnon, Rena; Welch, Brett D.] Navigen Inc, D Peptide Res Div, Salt Lake City, UT 84108 USA. RP Eckert, DM (reprint author), Univ Utah, Sch Med, Dept Biochem, 15 N Med Dr East,Rm 4100, Salt Lake City, UT 84112 USA. EM deckert@biochem.utah.edu; kay@biochem.utah.edu FU University of Utah; NIH [AI102347, GM82545]; U.S. Air Force; U.S. Department of Energy, Office of Science, Office of Basic Energy Sciences; DOE Office of Biological and Environmental Research; NIH, NIGMS FX We thank Hyung Kim and Dennis Winge for amino acid analysis. We also thank Yu-Chan Chen, Andrew Steiner, Ruei-Lin Hsu, and Niladri Sinha for help with molecular biology, protein purification, and preliminary characterization of the N-trimer mimics and C-peptides. For help with peptide synthesis and purification, we thank Maritza Quintero and Dasha Pruss, and we thank Matthew Movsesian for assistance and advice. This research was funded by a University of Utah Funding Incentive Seed grant to D.M.E. and M.S.K., NIH grant AI102347 to B.D.W. and M.S.K, and NIH grant GM82545 to D.M.E. and C.P.H.. We thank the U.S. Air Force for support of T.R.C.. Portions of this research were carried out at the Stanford Synchrotron Radiation Light Source, (SSRL), which is supported by the U.S. Department of Energy, Office of Science, Office of Basic Energy Sciences. The SSRL Structural Molecular Biology Program is supported by the DOE Office of Biological and Environmental Research, and by the NIH, NIGMS. Opinions, conclusions, interpretations, and recommendations are those of the authors and are not necessarily endorsed by the U.S. Army, U.S. Air Force, the NIH or NIGMS. The mention of trade names or commercial products does not constitute endorsement or recommendation for use by the Department of the Army, the Department of Defense, or the U.S. Air Force. NR 76 TC 8 Z9 8 U1 2 U2 19 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0961-8368 EI 1469-896X J9 PROTEIN SCI JI Protein Sci. PD APR PY 2015 VL 24 IS 4 BP 446 EP 463 DI 10.1002/pro.2578 PG 18 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA CE5KR UT WOS:000351873400003 PM 25287718 ER PT J AU Henein, NA Ma, Z Huang, SQ Bryzik, W Glidewell, J AF Henein, Naeim A. Ma, Zheng Huang, Shengqiang Bryzik, Walter Glidewell, John TI In Situ Wear Measuring Technique in Engine Cylinders SO TRIBOLOGY & LUBRICATION TECHNOLOGY LA English DT Article DE Automotive Tribology; Internal Combustion Engines, Gas; Wear and Failure; Surface Roughness ID RING WEAR; LINERS; BORES AB An in situ wear probe was developed to measure the rate of cylinder liner wear and its roughness at the top ring reversal point where severe wear can occur The wear probe can be removed from the cylinder block and replaced without the need for engine disassembly The wear probe is scanned at a laser stylus surface measuring station where its topography and wear are analyzed. The engine used is a single-cylinder, air-cooled gasoline engine. A sample of the surface properties and analysis is given. Experimental data are given for the wear rate and different roughness parameters and their variation over the first few hours of the break-in period. C1 [Henein, Naeim A.; Ma, Zheng] Wayne State Univ, Detroit, MI 48202 USA. [Huang, Shengqiang] Caterpillar Inc, Peoria, IL 61629 USA. [Bryzik, Walter] US Army TARDEC, Warren, MI USA. [Glidewell, John] Ford Motor Co, Dearborn, MI 48121 USA. RP Henein, NA (reprint author), Wayne State Univ, Detroit, MI 48202 USA. FU U.S. Army National Automotive Center; TARDEC, Warren, MI FX The sponsorship, technical and financial support of U.S. Army National Automotive Center and TARDEC, Warren, MI, are acknowledged. NR 17 TC 0 Z9 0 U1 1 U2 5 PU SOC TRIBOLOGISTS & LUBRICATION ENGINEERS PI PARK RIDGE PA 840 BUSSE HIGHWAY, PARK RIDGE, IL 60068 USA SN 1545-858X J9 TRIBOL LUBR TECHNOL JI Tribol. Lubr. Technol. PD APR PY 2015 VL 71 IS 4 BP 46 EP 53 PG 8 WC Engineering, Mechanical SC Engineering GA CE4DD UT WOS:000351780100012 ER PT J AU Leelawiwat, W Rutvisuttinunt, W Arroyo, M Mueanpai, F Kongpechsatit, O Chonwattana, W Chaikummao, S de Souza, M vanGriensven, F McNicholl, JM Curlin, ME AF Leelawiwat, Wanna Rutvisuttinunt, Wiriya Arroyo, Miguel Mueanpai, Famui Kongpechsatit, Oranuch Chonwattana, Wannee Chaikummao, Supaporn de Souza, Mark vanGriensven, Frits McNicholl, Janet M. Curlin, Marcel E. TI Increasing HIV-1 Molecular Complexity Among Men Who Have Sex with Men in Bangkok SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Article ID INJECTING DRUG-USERS; CIRCULATING RECOMBINANT FORM; TYPE-1 SUBTYPE E; NEUTRALIZING ANTIBODIES; NORTHERN THAILAND; GENETIC DIVERSITY; INFECTION; EPIDEMIOLOGY; CHINA; MSM AB In Thailand, new HIV-1 infections are largely concentrated in certain risk groups such as men who have sex with men (MSM), where annual incidence may be as high as 12% per year. The paucity of information on the molecular epidemiology of HIV-1 in Thai MSM limits progress in understanding the epidemic and developing new prevention methods. We evaluated HIV-1 subtypes in seroincident and seroprevalent HIV-1-infected men enrolled in the Bangkok MSM Cohort Study (BMCS) between 2006 and 2011. We characterized HIV-1 subtype in 231 seroprevalent and 194 seroincident subjects using the multihybridization assay (MHA). Apparent dual infections, recombinant strains, and isolates found to be nontypeable by MHA were further characterized by targeted genomic sequencing. Most subjects were infected with HIV-1 CRF01_AE (82%), followed by infections with recombinants (11%, primarily CRF01_AE/B recombinants), subtype B (5%), and dual infections (2%). More than 11 distinct chimeric patterns were observed among CRF01B_AE/B recombinants, most involving recombination within integrase. A significant increase in the proportion of nontypeable strains was observed among seroincident MSM between 2006 and 2011. CRF01_AE and subtype B were the most and least common infecting strains, respectively. The predominance of CRF01_AE among HIV-1 infections in Thai MSM participating in the BMCS parallels trends observed in Thai heterosexuals and injecting drug users. The presence of complex recombinants and a significant rise in nontypeable strains suggest ongoing changes in the genetic makeup of the HIV-1 epidemic in Thailand, which may pose challenges for HIV-1 prevention efforts and vaccine development. C1 [Leelawiwat, Wanna; Mueanpai, Famui; Kongpechsatit, Oranuch; Chonwattana, Wannee; Chaikummao, Supaporn; vanGriensven, Frits; McNicholl, Janet M.; Curlin, Marcel E.] Thailand MOPH US CDC Collaborat, Nonthaburi 11000, Thailand. [Rutvisuttinunt, Wiriya; Arroyo, Miguel] Armed Forces Res Inst Med Sci, Dept Retrovirol, Bangkok 10400, Thailand. [de Souza, Mark] Thai Red Cross AIDS Res Ctr, SEARCH Thailand, Bangkok, Thailand. [vanGriensven, Frits; McNicholl, Janet M.; Curlin, Marcel E.] Ctr Dis Control & Prevent, Div HIV AIDS Prevent, Atlanta, GA USA. RP Leelawiwat, W (reprint author), Thailand MOPH US CDC Collaborat, DMSC Bldg 2,Tivanon Rd, Nonthaburi 11000, Thailand. EM wannal@cdc.gov OI Arroyo, Miguel/0000-0001-7416-8867 FU U.S. military HIV-1 Research; Henry M. Jackson Foundation FX The authors would like to thank the participants in this study, and acknowledge the support and funding from the U.S. military HIV-1 Research and the Henry M. Jackson Foundation. We also thank Viseth Ngauy, Vatcharin Assawadarachai, Kultida Poltavee, Hathairat Savadsuk, and Suwittra Chaemchuen of the Armed Forces Research Institute of Medical Sciences, Thailand for their support of this study; Sodsai Tovanabutra, Gustavo Kijak, Eric Sander-Buell, Morgane Rolland, Francine McCutcheon, and Jerome Kim of the U.S. Military HIV Research Program for their technical and intellectual input; Jaray Tongtoyai, Atittaya Sangiamkittikul, Punneeporn Wasinrapee, Natthaga Sakulploy, Kusuma Auethavoranan, and Wanna Suwanaphan of the Thai MOPH US-CDC Collaboration (TUC) laboratory for processing and testing all the samples; Sarika Pattanasin, Boonyos Raengsakulrach, and Chonticha Kittinunvorakoon for helpful advice; and the remaining members of our collaborative study group. NR 53 TC 1 Z9 1 U1 0 U2 0 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0889-2229 EI 1931-8405 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD APR 1 PY 2015 VL 31 IS 4 BP 393 EP 400 DI 10.1089/aid.2014.0139 PG 8 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA CE5JR UT WOS:000351869400007 PM 25366819 ER PT J AU Harrison, SA AF Harrison, Stephen A. TI Nonalcoholic Fatty Liver Disease and Fibrosis Progression: The Good, the Bad, and the Unknown SO CLINICAL GASTROENTEROLOGY AND HEPATOLOGY LA English DT Editorial Material ID FOLLOW-UP; ASSOCIATION; DIAGNOSIS; RISK C1 Brooke Army Med Ctr, Dept Med, Div Gastroenterol, Houston, TX 78234 USA. RP Harrison, SA (reprint author), Brooke Army Med Ctr, Dept Med, Div Gastroenterol, Houston, TX 78234 USA. NR 13 TC 2 Z9 2 U1 0 U2 1 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1542-3565 EI 1542-7714 J9 CLIN GASTROENTEROL H JI Clin. Gastroenterol. Hepatol. PD APR PY 2015 VL 13 IS 4 BP 655 EP 657 DI 10.1016/j.cgh.2014.11.024 PG 3 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA CD7UL UT WOS:000351299300010 PM 25478921 ER PT J AU Leon, LR Bouchama, A AF Leon, Lisa R. Bouchama, Abderrezak TI Heat Stroke SO COMPREHENSIVE PHYSIOLOGY LA English DT Article ID TUMOR-NECROSIS-FACTOR; WHOLE-BODY HYPERTHERMIA; DISSEMINATED INTRAVASCULAR COAGULATION; ACUTE KIDNEY INJURY; PREOPTIC THERMOSENSITIVE NEURONS; HUMAN THERMOREGULATORY RESPONSES; SYSTEMIC INFLAMMATORY RESPONSE; MONOCYTE PROCOAGULANT ACTIVITY; MUSCLE SARCOPLASMIC-RETICULUM; ACUTE MYOCARDIAL-INFARCTION AB Heat stroke is a life-threatening condition clinically diagnosed as a severe elevation in body temperature with central nervous system dysfunction that often includes combativeness, delirium, seizures, and coma. Classic heat stroke primarily occurs in immunocompromised individuals during annual heat waves. Exertional heat stroke is observed in young fit individuals performing strenuous physical activity in hot or temperature environments. Long-term consequences of heat stroke are thought to be due to a systemic inflammatory response syndrome. This article provides a comprehensive review of recent advances in the identification of risk factors that predispose to heat stroke, the role of endotoxin and cytokines in mediation of multi-organ damage, the incidence of hypothermia and fever during heat stroke recovery, clinical biomarkers of organ damage severity, and protective cooling strategies. Risk factors include environmental factors, medications, drug use, compromised health status, and genetic conditions. The role of endotoxin and cytokines is discussed in the framework of research conducted over 30 years ago that requires reassessment to more clearly identify the role of these factors in the systemic inflammatory response syndrome. We challenge the notion that hypothalamic damage is responsible for thermoregulatory disturbances during heat stroke recovery and highlight recent advances in our understanding of the regulated nature of these responses. The need for more sensitive clinical biomarkers of organ damage is examined. Conventional and emerging cooling methods are discussed with reference to protection against peripheral organ damage and selective brain cooling. Published 2015. C1 [Leon, Lisa R.] US Army Res Inst Environm Med, Natick, MA 01760 USA. [Bouchama, Abderrezak] King Saud Bin Abdulaziz Univ Hlth Sci, King Abdullah Int Med Res Ctr, Dept Expt Med, King Abdulaziz Med City,Minist Natl Guard Hlth Af, Riyadh, Saudi Arabia. RP Leon, LR (reprint author), US Army Res Inst Environm Med, Natick, MA 01760 USA. EM lisa.r.leon.civ@mail.mil NR 420 TC 13 Z9 17 U1 6 U2 31 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 2040-4603 J9 COMPR PHYSIOL JI Compr. Physiol. PD APR PY 2015 VL 5 IS 2 BP 611 EP 647 DI 10.1002/cphy.c140017 PG 37 WC Physiology SC Physiology GA CE0JT UT WOS:000351491000006 PM 25880507 ER PT J AU Cho, JH AF Cho, Jin-Hee TI Tradeoffs between Trust and Survivability for Mission Effectiveness in Tactical Networks SO IEEE TRANSACTIONS ON CYBERNETICS LA English DT Article DE Group trust; mean time to mission failure (MTTMF); mission effectiveness; survivability; tactical network; trust; trust threshold ID ASPIRATION; LEVEL; COMMUNICATION; MANAGEMENT; COLLUSION AB In a military tactical network, maintaining trust among members in a mission group is critical to successful mission completion. However, maintaining high trust among group members in a resource-restricted tactical environment detrimentally reduces system lifetime, which may lead to mission failure or low mission effectiveness. In this paper, we aim to investigate the relationships between group trust and system lifetime [i.e., survivability measuring mean time to mission failure (MTTMF)] and to capture mission effectiveness achieved by the mission group based on the tradeoff between these two goals. We employ a composite trust capturing various angles of trust concept derived from communication, information, and social networks. We take a game theoretic approach using the so called Aoyagi's game theory, enforcing nodes to exhibit desirable behavior based on reward or penalty given by the system. In designing reward/penalty mechanisms, we adopt the concept of aspiration level, defining success or failure based on a goal set by the system, and prove there exists an optimal trust threshold maximizing both MTTMF(i.e., system lifetime/survivability) and group trust. We devised a mission effectiveness metric based on both the metrics having conflicting goals. We developed an analytical model using Stochastic Petri Nets, and validated the analytical results with simulation results. We conducted comparative performance analysis of the variations of the proposed scheme with respect to a node's decision nature (i.e., rational versus altruistic) and trust threshold policy (static versus dynamic) in resource-constrained tactical environments. C1 US Army Res Lab, Computat & Informat Sci Directorate, Adelphi, MD 20783 USA. RP Cho, JH (reprint author), US Army Res Lab, Computat & Informat Sci Directorate, Adelphi, MD 20783 USA. EM jinhee.cho@us.army.mil FU Department of Defense (DoD) through office of the Assistant Secretary of Defense for Research and Engineering (ASD R E) FX This work was supported by the Department of Defense (DoD) through the office of the Assistant Secretary of Defense for Research and Engineering (ASD R& E). The views and opinions of the author(s) do not reflect those of the DoD or ASD R& E. This paper was recommended by Associate Editor J. Liu. NR 34 TC 1 Z9 1 U1 1 U2 7 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 2168-2267 EI 2168-2275 J9 IEEE T CYBERNETICS JI IEEE T. Cybern. PD APR PY 2015 VL 45 IS 4 BP 754 EP 766 DI 10.1109/TCYB.2014.2335744 PG 13 WC Computer Science, Artificial Intelligence; Computer Science, Cybernetics SC Computer Science GA CE0BL UT WOS:000351467400013 PM 25069134 ER PT J AU Cloutier, R Sauser, B Bone, M Taylor, A AF Cloutier, Robert Sauser, Brian Bone, Mary Taylor, Andrew TI Transitioning Systems Thinking to Model-Based Systems Engineering: Systemigrams to SysML Models SO IEEE TRANSACTIONS ON SYSTEMS MAN CYBERNETICS-SYSTEMS LA English DT Article DE Model-based systems engineering (MBSE); SysML; systemigram; systems thinking ID MANAGEMENT AB A fundamental challenge for system engineers is to capture a problem with an effective model or framework and then facilitate transferring the information of that captured problem to practical systems engineering tools and methods. The early problem definition phase requires an application of systems thinking with adequate modeling tools and methods. Then, the later problem definition phase and early system architecting phase requires transferring the captured problem to systems engineering tools and methods through emerging techniques such as model-based systems engineering (MBSE) using SysML (MBSE is the practice of using a modeling tools to capture systems engineering diagrams). This paper presents a method for capturing a problem through systemigrams and the Boardman soft systems methodology and then directly translating the systemigrams into SysML diagrams. With MBSE increasing in usage, this method could provide a time savings opportunity during model development along with the possibility of lowering information distortion or loss that can occur during transformation of systems thinking to systems engineering activities. This paper includes a case study which demonstrates how the proposed approach was applied on a problem being considered by the U.S. Army-Contingency Basing for Small Combat Units. Finally, this paper will provide the conclusion on the development of the method and describe future research directions that can allow systems thinking and MBSE to function in a congruent methodology. C1 [Cloutier, Robert; Bone, Mary] Stevens Inst Technol, Hoboken, NJ 07030 USA. [Sauser, Brian] Univ N Texas, Denton, TX 76203 USA. [Taylor, Andrew] US Army Natick Soldier Res, Ctr Dev & Engn, Natick, MA 01760 USA. RP Sauser, B (reprint author), Univ N Texas, Denton, TX 76203 USA. EM brian.sauser@unt.edu FU Systems Engineering Research Center (SERC); University Affiliated Research Center FX This work was supported by the Systems Engineering Research Center (SERC). SERC is a federally funded University Affiliated Research Center managed by the Stevens Institute of Technology. This paper was recommended by Associate Editor K. W. Hipel. NR 41 TC 0 Z9 0 U1 5 U2 23 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 2168-2216 J9 IEEE T SYST MAN CY-S JI IEEE Trans. Syst. Man Cybern. -Syst. PD APR PY 2015 VL 45 IS 4 BP 662 EP 674 DI 10.1109/TSMC.2014.2379657 PG 13 WC Automation & Control Systems; Computer Science, Cybernetics SC Automation & Control Systems; Computer Science GA CE1BH UT WOS:000351545900010 ER PT J AU Crowell, TA Berry, SA Fleishman, JA LaRue, RW Korthuis, PT Nijhawan, AE Moore, RD Gebo, KA AF Crowell, Trevor A. Berry, Stephen A. Fleishman, John A. LaRue, Richard W. Korthuis, Philip T. Nijhawan, Ank E. Moore, Richard D. Gebo, Kelly A. CA HIV Res Network TI Impact of Hepatitis Coinfection on Healthcare Utilization Among Persons Living With HIV SO JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES LA English DT Article DE HIV; hepatitis B virus; hepatitis C virus; mental health; healthcare utilization; hospitalization ID C VIRUS-INFECTION; ACTIVE ANTIRETROVIRAL THERAPY; UNITED-STATES; HEPATOCELLULAR-CARCINOMA; HOSPITALIZATION RATES; MULTICENTER COHORT; VIRAL-HEPATITIS; NATURAL-HISTORY; HCV INFECTION; MORTALITY AB Hepatitis B virus (HBV) and hepatitis C virus (HCV) coinfection are increasingly important sources of morbidity among HIV-infected persons. We determined associations between hepatitis coinfection and healthcare utilization among HIV-infected adults at 4 US sites during 2006-2011. Outpatient HIV visits did not differ by hepatitis serostatus and decreased over time. Mental health visits were more common among HIV/HCV coinfected persons than among HIV monoinfected persons [incidence rate ratio (IRR): 1.27, 95% confidence interval (CI): 1.08 to 1.50]. Hospitalization rates were higher among all hepatitis-infected groups than among HIV monoinfected (HIV/HBV: IRR: 1.23, 95% CI: 1.05 to 1.44; HIV/HCV: IRR: 1.22, 95% CI: 1.10 to 1.36; HIV/HBV/HCV: IRR: 1.31, 95% CI: 1.02 to 1.68). These findings may inform the design of clinical services and allocation of resources. C1 [Crowell, Trevor A.; Berry, Stephen A.; LaRue, Richard W.; Moore, Richard D.; Gebo, Kelly A.] Johns Hopkins Univ, Sch Med, Dept Med, Div Infect Dis, Baltimore, MD 21205 USA. [Fleishman, John A.] Agcy Healthcare Res & Qual, Ctr Financing Access & Cost Trends, Rockville, MD USA. [Korthuis, Philip T.] Oregon Hlth & Sci Univ, Dept Med, Div Gen Internal Med & Geriatr, Portland, OR 97201 USA. [Nijhawan, Ank E.] Univ Texas SW Med Ctr Dallas, Dept Internal Med, Div Infect Dis, Dallas, TX 75390 USA. RP Crowell, TA (reprint author), Walter Reed Army Inst Res, US Mil HIV Res Program, 6720-A Rockledge Dr,Suite 400, Bethesda, MD 20817 USA. EM tcrowell@hivresearch.org FU Agency for Healthcare Research and Quality [HHSA290201100007C]; Health Resources and Services Administration [HHSH250201200008C]; National Institute of Allergy and Infectious Diseases [K23 AI084854]; National Center for Advancing Translational Sciences [KL2TR001103]; Tibotec FX Supported by the Agency for Healthcare Research and Quality (HHSA290201100007C), the Health Resources and Services Administration (HHSH250201200008C), the National Institute of Allergy and Infectious Diseases (K23 AI084854), and the National Center for Advancing Translational Sciences (KL2TR001103).; K.A.G. has been a consultant to Tibotec and BMS and received research funding from Tibotec. The remaining authors have no conflicts of interest to disclose. NR 37 TC 2 Z9 2 U1 0 U2 4 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1525-4135 EI 1077-9450 J9 JAIDS-J ACQ IMM DEF JI JAIDS PD APR 1 PY 2015 VL 68 IS 4 BP 425 EP 431 PG 7 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA CE1RC UT WOS:000351588600014 PM 25559601 ER PT J AU Ananworanich, J Sirivichayakul, S Pinyakorn, S Crowell, TA Trichavaroj, R Weerayingyong, J Chomchey, N Fletcher, JLK van Griensven, F Phanuphak, P Robb, ML Michael, NL Kim, JH Phanuphak, N AF Ananworanich, Jintanat Sirivichayakul, Sunee Pinyakorn, Suteeraporn Crowell, Trevor A. Trichavaroj, Rapee Weerayingyong, Jessica Chomchey, Nitiya Fletcher, James L. K. van Griensven, Frits Phanuphak, Praphan Robb, Merlin L. Michael, Nelson L. Kim, Jerome H. Phanuphak, Nittaya CA SEARCH RV 254 Study Grp TI High Prevalence of Transmitted Drug Resistance in Acute HIV-Infected Thai Men Who Have Sex With Men SO JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES LA English DT Article DE transmitted drug resistance; acute HIV; Thailand; men who have sex with men ID RESOURCE-LIMITED SETTINGS; ANTIRETROVIRAL THERAPY; REVERSE-TRANSCRIPTASE; NAIVE INDIVIDUALS; SCALING-UP; MUTATIONS; SURVEILLANCE; MULTICENTER; EPIDEMIC; BANGKOK AB As use of antiretroviral therapy in Thailand increases, so does the potential for transmission of drug-resistant HIV. We describe the prevalence of WHO surveillance drug resistance mutations among 120 subjects who underwent genotypic testing during acute HIV infection in Bangkok, Thailand. In this cohort of predominantly men who have sex with men, we observed an overall transmitted drug resistance prevalence of 9.2%, including nucleoside/nucleotide analog reverse transcriptase inhibitor 5.0%, nonnucleoside analog reverse transcriptase inhibitor 3.4%, and protease inhibitor 3.4%. These prevalence estimates are higher than previous reports of transmitted drug resistance in Thailand. Baseline drug resistance testing may be warranted, particularly among men who have sex with men. C1 [Ananworanich, Jintanat; Crowell, Trevor A.; Robb, Merlin L.; Michael, Nelson L.; Kim, Jerome H.] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD USA. [Ananworanich, Jintanat; Crowell, Trevor A.; Robb, Merlin L.] Henry M Jackson Fdn Adv Mil Med, Bethesda, MD USA. [Ananworanich, Jintanat; Pinyakorn, Suteeraporn; Weerayingyong, Jessica; Chomchey, Nitiya; Fletcher, James L. K.; Phanuphak, Praphan; Kim, Jerome H.; Phanuphak, Nittaya] SEARCH Thailand, Bangkok, Thailand. [Sirivichayakul, Sunee; Pinyakorn, Suteeraporn; Chomchey, Nitiya; Fletcher, James L. K.; van Griensven, Frits; Phanuphak, Praphan; Phanuphak, Nittaya] Thai Red Cross AIDS Res Ctr, Bangkok, Thailand. [Sirivichayakul, Sunee] Chulalongkorn Univ, Fac Med, Dept Med, Bangkok 10330, Thailand. [Trichavaroj, Rapee] Armed Forces Res Inst Med Sci, US Component, Dept Retrovirol, Bangkok 10400, Thailand. RP Ananworanich, J (reprint author), Walter Reed Army Inst Res, US Mil HIV Res Program, 6720A Rockledge Dr,Suite 400, Bethesda, MD 20817 USA. EM jananworanich@hivresearch.org FU Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc [W81XWH-07-2-0067, W81XWH-11-2-0174]; US Department of the Army [W81XWH-07-2-0067, W81XWH-11-2-0174]; Thai Red Cross AIDS Research Center FX Supported by cooperative agreements (W81XWH-07-2-0067 and W81XWH-11-2-0174) between The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc, and the US Department of the Army and by an intramural grant from the Thai Red Cross AIDS Research Center. The US Army Medical Research Acquisition Activity, 820 Chandler Street, Fort Detrick, MD 21702-5014, is the awarding and administering acquisition office for the cooperative agreement. Antiretroviral therapy was supported by the Thai Government Pharmaceutical Organization, Gilead, Merck, and Pfizer. NR 38 TC 4 Z9 4 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1525-4135 EI 1077-9450 J9 JAIDS-J ACQ IMM DEF JI JAIDS PD APR 1 PY 2015 VL 68 IS 4 BP 481 EP 485 PG 5 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA CE1RC UT WOS:000351588600022 PM 25559593 ER PT J AU Burns, JW Quartana, PJ Bruehl, S Janssen, I Dugan, SA Appelhans, B Matthews, KA Kravitz, HM AF Burns, John W. Quartana, Phillip J. Bruehl, Stephen Janssen, Imke Dugan, Sheila A. Appelhans, Bradley Matthews, Karen A. Kravitz, Howard M. TI Chronic pain, body mass index and cardiovascular disease risk factors: tests of moderation, unique and shared relationships in the Study of Women's Health Across the Nation (SWAN) SO JOURNAL OF BEHAVIORAL MEDICINE LA English DT Article DE Persistent pain; BMI; CVD risk factors; Moderation ID RESTING BLOOD-PRESSURE; REPORTING CHRONIC PAIN; CHRONIC SPINAL PAIN; GENERAL-POPULATION; MUSCULOSKELETAL PAIN; REGULATORY SYSTEMS; METABOLIC SYNDROME; PHYSICAL-ACTIVITY; HEART-DISEASE; UNITED-STATES AB Chronic pain may be related to cardiovascular disease (CVD) risk. The current study examined whether persistent bodily pain was related to cardiovascular disease risk factors, whether these effects were moderated by body mass index (BMI), and, if not, whether chronic pain accounted for unique variance in CVD risk factors. Participants were women (N = 2,135) in the Study of Women's Health Across the Nation. A high pain frequency variable (high pain in 0 through 4 assessments) was coded to reflect the frequency of high levels of bodily pain across the first 3 years of the study. Six CVD risk factors and BMI were measured at follow-up year 3. High pain frequency and BMI were correlated significantly with risk factors, although effects for the former were small. Hierarchical multiple regressions revealed high pain frequency x BMI interactions for 5 of 6 CVD risk factors. Dissecting the interactions revealed a similar pattern across 4 risk factors: for women with normal BMI, there was a "dose-response" in which increasing frequency of high pain revealed increasingly worse CVD risk factor levels, whereas for women with obese BMI, high pain frequency was unrelated to risk factors. For obese women, increasing frequency of high pain was associated with higher blood glucose. Although BMI is a well-established CVD risk factor, evaluation of CVD risk level may be improved by considering the incidence of persistent pain, particularly in normal weight women (BMI < 25 kg/m(2)) lower BMI. C1 [Burns, John W.; Janssen, Imke; Dugan, Sheila A.; Appelhans, Bradley; Kravitz, Howard M.] Rush Univ, Dept Behav Sci, Med Ctr, Chicago, IL 60612 USA. [Quartana, Phillip J.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Bruehl, Stephen] Vanderbilt Univ, Med Ctr, Nashville, TN USA. [Matthews, Karen A.] Univ Pittsburgh, Sch Med, Pittsburgh, PA USA. RP Burns, JW (reprint author), Rush Univ, Dept Behav Sci, Med Ctr, 1645 W Jackson Blvd, Chicago, IL 60612 USA. EM John_burns@rush.edu FU National Institutes of Health (NIH), DHHS, through the National Institute on Aging (NIA); National Institute of Nursing Research (NINR); NIH Office of Research on Women's Health (ORWH) [U01NR004061, U01AG012505, U01AG012535, U01AG012531, U01AG012539, U01AG012546, U01AG012553, U01AG012554, U01AG012495] FX The data used in this study are derived from The Study of Women's Health Across the Nation (SWAN). Grant support for SWAN is from the National Institutes of Health (NIH), DHHS, through the National Institute on Aging (NIA), the National Institute of Nursing Research (NINR) and the NIH Office of Research on Women's Health (ORWH) (Grants U01NR004061; U01AG012505, U01AG012535, U01AG012531, U01AG012539, U01AG012546, U01AG012553, U01AG012554, U01AG012495). The content of this manuscript is solely the responsibility of the authors and does not necessarily represent the official views of the NIA, NINR, ORWH or the NIH. The opinions or assertions contained herein are the private views of the authors, and are not to be construed as official, or as reflecting true views, of the Department of the Army or the Department of Defense. NR 46 TC 3 Z9 3 U1 2 U2 3 PU SPRINGER/PLENUM PUBLISHERS PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0160-7715 EI 1573-3521 J9 J BEHAV MED JI J. Behav. Med. PD APR PY 2015 VL 38 IS 2 BP 372 EP 383 DI 10.1007/s10865-014-9608-z PG 12 WC Psychology, Clinical SC Psychology GA CD5NV UT WOS:000351135900018 PM 25427423 ER PT J AU Pal, S Dauner, AL Valks, A Forshey, BM Long, KC Thaisomboonsuk, B Sierra, G Picos, V Talmage, S Morrison, AC Halsey, ES Comach, G Yasuda, C Loeffelholz, M Jarman, RG Fernandez, S An, US Kochel, TJ Jasper, LE Wu, SJL AF Pal, Subhamoy Dauner, Allison L. Valks, Andrea Forshey, Brett M. Long, Kanya C. Thaisomboonsuk, Butsaya Sierra, Gloria Picos, Victor Talmage, Sara Morrison, Amy C. Halsey, Eric S. Comach, Guillermo Yasuda, Chadwick Loeffelholz, Michael Jarman, Richard G. Fernandez, Stefan An, Ung Sam Kochel, Tadeusz J. Jasper, Louis E. Wu, Shuenn-Jue L. TI Multicountry Prospective Clinical Evaluation of Two Enzyme-Linked Immunosorbent Assays and Two Rapid Diagnostic Tests for Diagnosing Dengue Fever SO JOURNAL OF CLINICAL MICROBIOLOGY LA English DT Article ID IMMUNOGLOBULIN-M; VIRUS-INFECTION; CAPTURE ELISA; IMMUNOCHROMATOGRAPHIC TEST; CELL-CULTURES; NS1 ANTIGEN; ANTIBODY; ACCURACY; IDENTIFICATION; SENSITIVITY AB We evaluated four dengue diagnostic devices from Alere, including the SD Bioline Dengue Duo (nonstructural [NS] 1 Ag and IgG/IgM), the Panbio Dengue Duo Cassette (IgM/IgG) rapid diagnostic tests (RDTs), and the Panbio dengue IgM and IgG capture enzyme-linked immunosorbent assays (ELISAs) in a prospective, controlled, multicenter study in Peru, Venezuela, Cambodia, and the United States, using samples from 1,021 febrile individuals. Archived, well-characterized samples from an additional 135 febrile individuals from Thailand were also used. Reference testing was performed on all samples using an algorithm involving virus isolation, in-house IgM and IgG capture ELISAs, and plaque reduction neutralization tests (PRNT) to determine the infection status of the individual. The primary endpoints were the clinical sensitivities and specificities of these devices. The SD Bioline Dengue Duo had an overall sensitivity of 87.3% (95% confidence interval [CI], 84.1 to 90.2%) and specificity of 86.8% (95% CI, 83.9 to 89.3%) during the first 14 days post-symptom onset (p.s.o.). The Panbio Dengue Duo Cassette demonstrated a sensitivity of 92.1% (87.8 to 95.2%) and specificity of 62.2% (54.5 to 69.5%) during days 4 to 14 p.s.o. The Panbio IgM capture ELISA had a sensitivity of 87.6% (82.7 to 91.4%) and specificity of 88.1% (82.2 to 92.6%) during days 4 to 14 p.s.o. Finally, the Panbio IgG capture ELISA had a sensitivity of 69.6% (62.1 to 76.4%) and a specificity of 88.4% (82.6 to 92.8%) during days 4 to 14 p.s.o. for identification of secondary dengue infections. This multicountry prospective study resulted in reliable real-world performance data that will facilitate data-driven laboratory test choices for managing patient care during dengue outbreaks. C1 [Pal, Subhamoy; Dauner, Allison L.; Kochel, Tadeusz J.; Wu, Shuenn-Jue L.] Naval Med Res Ctr, Silver Spring, MD 20910 USA. [Valks, Andrea] Alere, Brisbane, Qld, Australia. [Forshey, Brett M.; Long, Kanya C.; Morrison, Amy C.; Halsey, Eric S.] US Naval Med Res Unit 6, Lima, Peru. [Sierra, Gloria; Picos, Victor; Comach, Guillermo] Univ Carabobo BIOMED UC, Lab Reg Diagnost & Invest Dengue & Otras Enfermed, Inst Invest Biomed, Maracay, Venezuela. [Yasuda, Chadwick] US Naval Med Res Unit 2, Phnom Penh, Cambodia. [Talmage, Sara; Loeffelholz, Michael] Univ Texas Med Branch, Galveston, TX 77555 USA. [Long, Kanya C.; Morrison, Amy C.] Univ Calif Davis, Davis, CA 95616 USA. [Jarman, Richard G.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Thaisomboonsuk, Butsaya; Fernandez, Stefan] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Jasper, Louis E.] US Army Med Mat Dev Act, Frederick, MD USA. [An, Ung Sam] Natl Inst Publ Hlth, Phnom Penh, Cambodia. RP Pal, S (reprint author), Naval Med Res Ctr, Silver Spring, MD 20910 USA. EM subhamoy.pal.ctr@mail.mil RI Pal, Subhamoy/A-9526-2015; OI Pal, Subhamoy/0000-0003-0133-8444; Dauner, Allison/0000-0001-7346-7355 FU Military Infectious Diseases Research Program [L0091_07_NM, L010011_09_NM, L0185_10_NM, L0186_10_NM, L0257_12_NM, L0262_12_NM]; [6000.RAD1.L.A1220] FX This work was funded by the Military Infectious Diseases Research Program, proposal numbers L0091_07_NM, L010011_09_NM, L0185_10_NM, L0186_10_NM, L0257_12_NM, and L0262_12_NM. The work was supported by Work Unit Number 6000.RAD1.L.A1220. NR 58 TC 5 Z9 5 U1 0 U2 1 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0095-1137 EI 1098-660X J9 J CLIN MICROBIOL JI J. Clin. Microbiol. PD APR PY 2015 VL 53 IS 4 BP 1092 EP 1102 DI 10.1128/JCM.03042-14 PG 11 WC Microbiology SC Microbiology GA CD8QA UT WOS:000351359500008 PM 25588659 ER PT J AU Milillo, M Kwak, YI Snesrud, E Waterman, PE Lesho, E McGann, P AF Milillo, Michael Kwak, Yoon I. Snesrud, Erik Waterman, Paige E. Lesho, Emil McGann, Patrick TI Correction for Milillo et al., Rapid and Simultaneous Detection of bla(KPC) and bla(NDM) by Use of Multiplex Real-Time PCR (vol 51, pg 1247, 2013) SO JOURNAL OF CLINICAL MICROBIOLOGY LA English DT Correction C1 [Milillo, Michael; Kwak, Yoon I.; Snesrud, Erik; Waterman, Paige E.; Lesho, Emil; McGann, Patrick] Walter Reed Army Inst Res, Multidrug Resistant Organism Repository & Surveil, Silver Spring, MD 20910 USA. RP Milillo, M (reprint author), Walter Reed Army Inst Res, Multidrug Resistant Organism Repository & Surveil, Silver Spring, MD 20910 USA. NR 1 TC 0 Z9 0 U1 0 U2 2 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0095-1137 EI 1098-660X J9 J CLIN MICROBIOL JI J. Clin. Microbiol. PD APR PY 2015 VL 53 IS 4 BP 1460 EP 1460 DI 10.1128/JCM.00373-15 PG 1 WC Microbiology SC Microbiology GA CD8QA UT WOS:000351359500077 PM 25788716 ER PT J AU Schlussel, AT Lustik, MB Johnson, EK Maykel, JA Champagne, BJ Goldberg, JE Steele, SR AF Schlussel, Andrew T. Lustik, Michael B. Johnson, Eric K. Maykel, Justin A. Champagne, Brad J. Goldberg, Joel E. Steele, Scott R. TI Do the Advantages of a Minimally Invasive Approach Remain in Complex Colorectal Procedures? A Nationwide Comparison SO DISEASES OF THE COLON & RECTUM LA English DT Article DE Laparoscopy; Population database; Postoperative complications; Total abdominal colectomy; Transverse colectomy ID OPEN COLECTOMY; COLON-CANCER; LAPAROSCOPIC COLECTOMY; ASSISTED RESECTION; TERM OUTCOMES; CLASICC TRIAL; CARE; DISPARITIES AB BACKGROUND: Since the introduction of laparoscopic colectomy, experience and technology continue to improve. Although accepted for many colorectal conditions, its use and outcomes in complex procedures are less understood. OBJECTIVE: The purpose of this work was to compare the perioperative outcomes of laparoscopic transverse colectomy and total abdominal colectomy (study group) with an open approach (comparative group) and the more established laparoscopic right, left, and sigmoid colectomies (control group). DESIGN: This was a retrospective review of the Nationwide Inpatient Sample (2008-2011) of all patients undergoing elective right, left, sigmoid, total, or transverse colectomy as identified by International Classification of Diseases, Ninth Revision, Clinical Modification procedure codes. Risk-adjusted 30-day outcomes were assessed using regression modeling accounting for patient characteristics, comorbidities, and surgical procedures. SETTINGS: The study included a national sample from a population database. PATIENTS: There were 45,771 admissions: 2946 in the study group, 36,949 in the control group, and 5876 in the open comparative group. MAIN OUTCOME MEASURES: Mortality was the primary outcome. Secondary outcomes included in-hospital complications, length of stay, and hospital charges. RESULTS: The patients were predominantly white (73%), had private insurance (64%), and underwent surgery at urban centers (92%). Mortality was similar between the study and control groups (0.42% vs 0.51%; p = 0.52), with a higher complication rate in the study group (19% vs 14%; p < 0.01). The study group was also associated with a lower mortality rate compared with the open group (0.51% vs 2.20%; p < 0.01), which remained consistent after adjusting for covariates (OR, 0.38 [95% CI, 0.20-0.71]; p < 0.01). The study group had fewer complications overall compared with the open group (19% vs 27%; p < 0.01) and a shorter median length of stay (4.6 vs 6.3 days; p < 0.01). LIMITATIONS: This was a retrospective study using an administrative database. CONCLUSIONS: A laparoscopic approach for total abdominal and transverse colectomies has similar mortality rates and slightly higher complications than the more established laparoscopic colectomy procedures and improved perioperative outcomes when compared with an open technique (see Video, Supplemental Digital Content 1, http://links.lww.com/DCR/A178). C1 [Schlussel, Andrew T.] Tripler Army Med Ctr, Dept Surg, Honolulu, HI 96859 USA. [Lustik, Michael B.] Tripler Army Med Ctr, Dept Clin Invest, Honolulu, HI 96859 USA. [Johnson, Eric K.; Steele, Scott R.] Madigan Army Med Ctr, Dept Surg, Ft Lewis, WA USA. [Maykel, Justin A.] Univ Massachusetts, Mem Med Ctr, Div Colorectal Surg, Worcester, MA 01605 USA. [Champagne, Brad J.] Univ Hosp Case Med Ctr, Dept Surg, Div Colorectal Surg, Cleveland, OH USA. [Goldberg, Joel E.] Harvard Univ, Brigham & Womens Hosp, Sect Colorectal Surg, Sch Med, Boston, MA 02115 USA. RP Steele, SR (reprint author), Madigan Army Med Ctr, 9040 Jackson Ave, Puyallup, WA 98433 USA. EM harkersteele@mac.com NR 24 TC 4 Z9 4 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0012-3706 EI 1530-0358 J9 DIS COLON RECTUM JI Dis. Colon Rectum PD APR PY 2015 VL 58 IS 4 BP 431 EP 443 DI 10.1097/DCR.0000000000000325 PG 13 WC Gastroenterology & Hepatology; Surgery SC Gastroenterology & Hepatology; Surgery GA CD3IX UT WOS:000350972900017 PM 25751800 ER PT J AU Massey, TC AF Massey, T. Chris TI Locally constrained nodal connectivity refinement procedures for unstructured triangular finite element meshes SO ENGINEERING WITH COMPUTERS LA English DT Article DE Unstructured triangular mesh; Mesh quality; Nodal connectivity AB This paper presents specific procedures for locally refining nodal connectivity of two-dimensional unstructured triangular meshes to improve the quality of the mesh as well as to increase solution accuracy and computational speed. Details of the procedure are outlined along with a discussion of similar work, and an example problem from hydrodynamics is shown. C1 US Army Corps Engineers, Engn Res & Dev Ctr, Coastal & Hydraul Lab, Vicksburg, MS 39180 USA. RP Massey, TC (reprint author), US Army Corps Engineers, Engn Res & Dev Ctr, Coastal & Hydraul Lab, Vicksburg, MS 39180 USA. EM Chris.Massey@usace.army.mil FU NRL FX Portions of this work were initially performed while the author was employed at the Oceanography Division of the Naval Research Laboratory (NRL) and the remainder was completed at the U.S. Army Corps of Engineers, Engineer Research and Development Center as part of the Coastal Storm Modeling System Work Unit of the Flood and Coastal Research program. The author would like to thank Ben Holladay, an NRL STEP student at the time, for his efforts with some of the initial Matlab coding and testing inside of MeshGUI and to acknowledge the support of Dr. Cheryl Ann Blain of NRL in helping to fund some of the initial work that is included in MeshGUI. The author would especially like to thank the reviewers for their time, effort and useful comments in preparing this paper. NR 11 TC 0 Z9 0 U1 0 U2 1 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0177-0667 EI 1435-5663 J9 ENG COMPUT-GERMANY JI Eng. Comput. PD APR PY 2015 VL 31 IS 2 BP 375 EP 386 DI 10.1007/s00366-014-0357-y PG 12 WC Computer Science, Interdisciplinary Applications; Engineering, Mechanical SC Computer Science; Engineering GA CD6MT UT WOS:000351203900012 ER PT J AU Rush, JK Astur, N Scott, S Kelly, DM Sawyer, JR Warner, WC AF Rush, Jeremy K. Astur, Nelson Scott, Stephanie Kelly, Derek M. Sawyer, Jeffrey R. Warner, William C., Jr. TI Use of Magnetic Resonance Imaging in the Evaluation of Spondylolysis SO JOURNAL OF PEDIATRIC ORTHOPAEDICS LA English DT Article DE spondylolysis; adolescents; diagnosis; MRI; CT ID LUMBAR PARS INTERARTICULARIS; LOW-BACK-PAIN; COMPUTED-TOMOGRAPHY; STRESS-FRACTURES; NATURAL-HISTORY; FOLLOW-UP; SPONDYLOLISTHESIS; MRI; ADOLESCENTS; CHILDREN AB Background: In early studies, magnetic resonance imaging (MRI) had low sensitivity and positive predictive value in the evaluation of the pars interarticularis pathology; however, more recent reports have suggested an expanded role for MRI. The purpose of the present study was to evaluate the effectiveness of MRI in the diagnosis of pars injuries and compare it to computed tomography (CT), which was used as the reference "gold standard" for the detection of fractures. Methods: The radiographic and clinic data of 93 adolescents and young adults with a presumptive diagnosis of spondylolysis based upon history and clinic examination were reviewed. Only 26 patients who had MRI and CT images obtained within 30 days of each other were included. All images were reviewed by a fellowship-trained musculoskeletal radiologist and fellowship-trained pediatric orthopaedist. Results: Overall, 39 individual pars lesions (stress reaction or fracture) were identified. MRI was effective in identifying 36 pars lesions. MRI identified 11 lesions in 9 patients with negative CT. Seven of these lesions were stress reactions (grade 1), whereas 4 were frank fractures. Three pars injuries were noted on CT while the MRI was negative. Conclusions: MRI is an effective method (92% sensitivity) for detecting pars injuries. It can detect stress reactions when a fracture is not visible on CT scan, allowing early treatment of these prelysis lesions. The 92% sensitivity of MRI is comparable with that of other diagnostic modalities such as bone scan, with the advantage of no radiation exposure. MRI should be strongly considered as the advanced imaging modality of choice in the evaluation of patients with suspected spondylolysis. C1 [Rush, Jeremy K.] Ft Sam, Brooke Army Med Ctr, Houston, TX USA. [Astur, Nelson; Scott, Stephanie; Kelly, Derek M.; Sawyer, Jeffrey R.; Warner, William C., Jr.] Univ Tennessee, Dept Orthopaed Surg, Le Bonheur Childrens Hosp, Campbell Clin, Memphis, TN 38138 USA. RP Warner, WC (reprint author), Univ Tennessee, Dept Orthopaed Surg, Le Bonheur Childrens Hosp, Campbell Clin, 1400 S Germantown Rd Germantown, Memphis, TN 38138 USA. EM wcwarner@comcast.net RI Astur, Nelson/F-3267-2015 OI Astur, Nelson/0000-0002-2608-2118 NR 25 TC 3 Z9 3 U1 6 U2 22 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0271-6798 EI 1539-2570 J9 J PEDIATR ORTHOPED JI J. Pediatr. Orthop. PD APR-MAY PY 2015 VL 35 IS 3 BP 271 EP 275 PG 5 WC Orthopedics; Pediatrics SC Orthopedics; Pediatrics GA CD2HF UT WOS:000350895500011 PM 24978120 ER PT J AU Mrozek, RA Leighliter, B Gold, CS Beringer, IR Yu, JH VanLandingham, MR Moy, P Foster, MH Lenhart, JL AF Mrozek, Randy A. Leighliter, Brad Gold, Christopher S. Beringer, Ian R. Yu, Jian H. VanLandingham, Mark R. Moy, Paul Foster, Mark H. Lenhart, Joseph L. TI The relationship between mechanical properties and ballistic penetration depth in a viscoelastic gel SO JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS LA English DT Article ID PRESSURE-SENSITIVE ADHESIVES; THERMOPLASTIC ELASTOMER GELS; TRIBLOCK COPOLYMER GELS; DOUBLE-NETWORK GELS; POLYMER GELS; GELATIN; IMPACT; TEMPERATURE; RHEOLOGY; BEHAVIOR AB The fundamental material response of a viscoelastic material when impacted by a ballistic projectile has important implication for the defense, law enforcement, and medical communities particularly for the evaluation of protective systems. In this paper, we systematically vary the modulus and toughness of a synthetic polymer gel to determine their respective influence on the velocity-dependent penetration of a spherical projectile. The polymer gels were characterized using tensile, compression, and rheological testing taking special care to address the unique challenges associated with obtaining high fidelity mechanical data on highly conformal materials. The depth of penetration data was accurately described using the elastic Froude number for viscoelastic gels ranging in Young's modulus from similar to 60 to 630 kPa. The minimum velocity of penetration was determined to scale with the gel toughness divided by the gel modulus, a qualitative estimate for the zone of deformation size scale upon impact. We anticipate that this work will provide insight into the critical material factors that control ballistic penetration behavior in soft materials and aid in the design and development of new ballistic testing media. Published by Elsevier Ltd. C1 [Mrozek, Randy A.; Leighliter, Brad; Gold, Christopher S.; Beringer, Ian R.; Yu, Jian H.; VanLandingham, Mark R.; Moy, Paul; Foster, Mark H.; Lenhart, Joseph L.] US Army Res Lab, Aberdeen, MD 21005 USA. RP Mrozek, RA (reprint author), US Army Res Lab, Aberdeen, MD 21005 USA. EM randy.a.mrozek.civ@mail.mil; jospeh.l.lenhart.civ@mail.mil NR 32 TC 4 Z9 4 U1 6 U2 38 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1751-6161 EI 1878-0180 J9 J MECH BEHAV BIOMED JI J. Mech. Behav. Biomed. Mater. PD APR PY 2015 VL 44 BP 109 EP 120 DI 10.1016/j.jmbbm.2015.01.001 PG 12 WC Engineering, Biomedical; Materials Science, Biomaterials SC Engineering; Materials Science GA CD1LK UT WOS:000350836200012 PM 25637822 ER PT J AU Bates, ME Fox-Lent, C Seymour, L Wender, BA Linkov, I AF Bates, Matthew E. Fox-Lent, Cate Seymour, Linda Wender, Ben A. Linkov, Igor TI Life cycle assessment for dredged sediment placement strategies SO SCIENCE OF THE TOTAL ENVIRONMENT LA English DT Article DE Life-cycle assessment; Dredging; Sediments; Beneficial use; Long Island Sound ID MULTICRITERIA DECISION-ANALYSIS; REMEDIATION AB Dredging to maintain navigable waterways is important for supporting trade and economic sustainability. Dredged sediments are removed from the waterways and then must be managed in a way that meets regulatory standards and properly balances management costs and risks. Selection of a best management alternative often results in stakeholder conflict regarding tradeoffs between local environmental impacts associated with less expensive alternatives (e.g., open water placement), more expensive measures that require sediment disposal in constructed facilities far away (e.g., landfills), or beneficial uses that may be perceived as risky (e.g., beach nourishment or island creation). Current sediment-placement decisions often focus on local and immediate environmental effects from the sediment itself, ignoring a variety of distributed and long-term effects from transportation and placement activities. These extended effects have implications for climate change, resource consumption, and environmental and human health, which may be meaningful topics for many stakeholders not currently considered. Life-Cycle Assessment (LCA) provides a systematic and quantitative method for accounting for this wider range of impacts and benefits across all sediment management project stages and time horizons. This paper applies a cradle-to-use LCA to dredged-sediment placement through a comparative analysis of potential upland, open water, and containment-island placement alternatives in the Long Island Sound region of NY/CT. Results suggest that, in cases dealing with uncontaminated sediments, upland placement may be the most environmentally burdensome alternative, per ton-kilometer of placed material, due to the emissions associated with diesel fuel combustion and electricity production and consumption required for the extra handling and transportation. These results can be traded-off with the ecosystem impacts of the sediments themselves in a decision-making framework. Published by Elsevier B.V. C1 [Bates, Matthew E.; Fox-Lent, Cate; Linkov, Igor] US Army Corps Engineers, Engineer Res & Dev Ctr, Environm Lab, Concord, MA 01742 USA. [Seymour, Linda] MIT, Dept Civil & Environm Engn, Cambridge, MA 02139 USA. [Wender, Ben A.] Arizona State Univ, Sch Sustainable Engn & Built Environm, Phoenix, AZ 85004 USA. RP Bates, ME (reprint author), US Army Corps Engineers, Engineer Res & Dev Ctr, Environm Lab, 696 Virginia Rd, Concord, MA 01742 USA. EM Matthew.E.Bates@usace.army.mil; Catherine.Fox-Lent@usace.army.mil; lseymour@mit.edu; bwender@asu.edu; Igor.Linkov@usace.army.mil FU USACE Dredging Operations and Environmental Research program FX The authors acknowledge funding from the USACE Dredging Operations and Environmental Research program. The authors thank Dr. Todd Bridges as program manager and Mary Hwang for her formatting assistance. Permission to publish this work was granted by the USACE Chief of Engineers. NR 28 TC 5 Z9 5 U1 8 U2 37 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0048-9697 EI 1879-1026 J9 SCI TOTAL ENVIRON JI Sci. Total Environ. PD APR 1 PY 2015 VL 511 BP 309 EP 318 DI 10.1016/j.scitotenv.2014.11.003 PG 10 WC Environmental Sciences SC Environmental Sciences & Ecology GA CC6YC UT WOS:000350513900032 PM 25553545 ER PT J AU Chapman, ED Hearn, AR Singer, GP Brostoff, WN LaCivita, PE Klimley, AP AF Chapman, Eric D. Hearn, Alex R. Singer, Gabriel P. Brostoff, William N. LaCivita, Peter E. Klimley, A. Peter TI Movements of steelhead (Oncorhynchus mykiss) smolts migrating through the San Francisco Bay Estuary SO ENVIRONMENTAL BIOLOGY OF FISHES LA English DT Article DE Steelhead; Migration; Tide; Acoustic telemetry; Sacramento River; San Francisco Bay Estuary ID JUVENILE STEELHEAD; CHINOOK SALMON; RIVER; SURVIVAL; HATCHERY; CALIFORNIA; TELEMETRY; PATTERNS; BEHAVIOR; COLUMBIA AB We used acoustic telemetry to monitor the out-migration of 1,000 steelhead smolts (Oncorhynchus mykiss) through the San Francisco Bay Estuary during spring of 2009 and 2010. The smolts transited the estuary rapidly (2-4 days) and utilized flows in the main channel during their migration. Fewer smolts were detected in marinas, tributaries and other shallow areas surrounding the estuary. Many of the smolts made repeated upriver and downriver movements that were related to the tidal flow, moving upstream during flood tides and downstream during ebb tides. These results show that steelhead smolts migrating from the Sacramento River transit rapidly through the lower reaches and do not use the estuary for feeding, rearing, or smoltification purposes. C1 [Chapman, Eric D.; Hearn, Alex R.; Singer, Gabriel P.; Klimley, A. Peter] Univ Calif Davis, Dept Wildlife Fish & Conservat Biol, Davis, CA 95616 USA. [Brostoff, William N.; LaCivita, Peter E.] US Army Corps Engineers, San Francisco, CA 94103 USA. RP Chapman, ED (reprint author), Univ Calif Davis, Dept Wildlife Fish & Conservat Biol, 1331 Acad Surge,One Shields Ave, Davis, CA 95616 USA. EM edchapman@ucdavis.edu FU US Army Corps of Engineers, San Francisco District FX This study was funded by the US Army Corps of Engineers, San Francisco District to provide information to the Long Term Management Strategy for fish movements in San Francisco Bay relative to dredging and dredged material placement operations. The research presented in this manuscript was conducted under a protocol that was reviewed and approved by the University of California Davis Institutional Animal Care and Use Committee (IUCAC). The authors would like to thank Chuck Morton and Charlotte Cashin for scheduling boat time and assisting on the Caltrans vessel with the maintenance of the monitors deployed on bridges. We greatly appreciate the help from everyone at the UC Davis Biotelemetry Laboratory (Mike Thomas, Denise Tu, Michelle Buckhorn, Anna Steel and Jamilynn Poletto) for volunteering their time to assist with the surgical implantation of the tags and for assistance in maintaining the arrays. We would also like to thank Arnold Ammann and Cyril Michel at the Santa Cruz office of the NMFS for maintaining the database. Thanks to Kurt Brown, Scott Hamelberg and Kevin Niemala at the Coleman National Fish Hatchery. NR 29 TC 0 Z9 0 U1 1 U2 14 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0378-1909 EI 1573-5133 J9 ENVIRON BIOL FISH JI Environ. Biol. Fishes PD APR PY 2015 VL 98 IS 4 BP 1069 EP 1080 DI 10.1007/s10641-014-0341-9 PG 12 WC Ecology; Marine & Freshwater Biology SC Environmental Sciences & Ecology; Marine & Freshwater Biology GA CC7RY UT WOS:000350567300009 ER PT J AU Min, KS Ryan, PM AF Min, Kyong S. Ryan, Paul M. TI Arthroscopic Allograft Cartilage Transfer for Osteochondral Defects of the Talus SO ARTHROSCOPY TECHNIQUES LA English DT Article ID LESIONS; TRANSPLANTATION AB Arthroscopic treatment of osteochondral defects is well established but has had mixed results in larger lesions and revision operations. Particulated allograft cartilage transfer may provide an arthroscopic option for lesions that would otherwise have been treated through open approaches or osteotomies. The procedure is performed under noninvasive distraction with standard arthroscopic portals. C1 [Min, Kyong S.] Brian Allgood Army Community Hosp, Seoul, South Korea. [Ryan, Paul M.] Tripler Army Med Ctr, Honolulu, HI 96859 USA. RP Min, KS (reprint author), Alpha Co, Brian Allgood Army Community Hosp, 121st CSH,Unit 15244,Box 437, APO, AP 96205 USA. EM kyong.s.min@gmail.com NR 5 TC 1 Z9 1 U1 0 U2 1 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 2212-6287 J9 ARTHROSC TEC JI Arthrosc. Tec. PD APR PY 2015 VL 4 IS 2 BP E175 EP E178 DI 10.1016/j.eats.2015.01.003 PG 4 WC Orthopedics SC Orthopedics GA DU5AX UT WOS:000382225400015 PM 26052496 ER PT J AU Peltzer, J Lund, K Lataillade, JJ AF Peltzer, Juliette Lund, Kyle Lataillade, Jean-Jacques TI Paracrine properties of Mesenchymal Stromal Cells SO BULLETIN DE L ACADEMIE NATIONALE DE MEDECINE LA French DT Article DE MESENCHYMAL STROMAL CELLS; CELL- AND TISSUE-BASED THERAPY; Exo-SOMES ID THERAPY POSITION STATEMENT; HEMATOPOIETIC STEM-CELLS; SUPPRESS T-LYMPHOCYTE; ACUTE LUNG INJURY; BONE-MARROW; INTERNATIONAL-SOCIETY; IN-VITRO; SECRETION; MICROVESICLES; INFLAMMATION AB Mesenchymal stromal cells are multipotent cells found in a large number of adult tissues. Their ability to participate in the repair of these damaged tissues is the origin of the enthusiasm that they elicit in the field of cell therapy. It gradually became apparent that their ability to change a pathological environment is more related to their ability to modulate the behavior of other cell types than their capacity of differentiation. Recent years have expanded the scope of our knowledge about their way of communication with their environment but also the amount of information that they receive from this environment. In this brief review, we will present some of the mechanisms by which sMSCs can communicate remotely with other cell types and how it currently appears possible to direct the secretion pattern of these cells C1 [Peltzer, Juliette; Lund, Kyle; Lataillade, Jean-Jacques] IRBA, Dept Soutien Med Chirurg Forces, Unite Therapie Cellulaire & Reparat Tissulaire, BP 73, F-91223 Bretigny Sur Orge, France. [Peltzer, Juliette; Lund, Kyle; Lataillade, Jean-Jacques] Ctr Transfus Sanguine Armees, F-92141 Clamart, France. [Lund, Kyle] US Army, Med Res & Mat Command, Ft Detrick, MD 21702 USA. RP Peltzer, J (reprint author), IRBA, Dept Soutien Med Chirurg Forces, Unite Therapie Cellulaire & Reparat Tissulaire, BP 73, F-91223 Bretigny Sur Orge, France. NR 50 TC 0 Z9 0 U1 1 U2 1 PU ELSEVIER MASSON SAS EDITEUR PI ISSY LES MOULINEAUX CEDEX PA 62, RUE CAMILLE DESMOULINS, ISSY LES MOULINEAUX CEDEX, 92442, FRANCE SN 0001-4079 J9 B ACAD NAT MED PARIS JI Bull. Acad. Natl. Med. PD APR-MAY PY 2015 VL 199 IS 4-5 BP 501 EP 514 PG 14 WC Medicine, General & Internal SC General & Internal Medicine GA DQ7JW UT WOS:000379384200005 PM 27509668 ER PT J AU Bodhidatta, L Abente, E Neesanant, P Nakjarung, K Sirichote, P Bunyarakyothin, G Vithayasai, N Mason, CJ AF Bodhidatta, Ladaporn Abente, Eugenio Neesanant, Pimmnapar Nakjarung, Kaewkanya Sirichote, Pantip Bunyarakyothin, Gaysorn Vithayasai, Niyada Mason, Carl J. TI Molecular Epidemiology and Genotype Distribution of Noroviruses in Children in Thailand From 2004 to 2010: A Multi-Site Study SO JOURNAL OF MEDICAL VIROLOGY LA English DT Article DE pediatric; diarrhea; surveillance ID NORWALK-LIKE VIRUSES; ACUTE GASTROENTERITIS; GENETIC DIVERSITY; UNITED-STATES; CHIANG-MAI; VACCINE DEVELOPMENT; OUTBREAKS; SAPOVIRUS; EMERGENCE; VARIANTS AB This study identified norovirus in children presenting with acute gastroenteritis and determined the capsid genotypes of the circulating norovirus strains in multiple regions in Thailand during October 2004 to December 2006 and March 2008 to August 2010. A total of 7,420 stool samples were collected from both cases (3621) and controls (3799). The stool samples were screened by two real-time RT-PCR assays to detect genogroup I and genogroup II noroviruses. Norovirus-positive samples were identified in 516 cases (14.3%) and 181 controls (4.8%) with more than half of norovirus positive samples from 7-24 months old children. Positive samples were sequenced and genotyped for the capsid gene. GII.4 was the genotype observed most frequently (56.4%) followed by GII.3 (28.2%). Five peaks of infection were observed, with predominant capsid genotypes that alternated during the surveillance periods between GII.4 and GII.3. Analyses of positive samples showed variation in genotype from each region as well as from different study periods. This emphasizes the importance of multi-site studies to investigate norovirus epidemiology. Additionally, the observed regional and temporal variations suggest that a systematic nation-wide surveillance effort in Thailand is needed to track the continually changing norovirus epidemiology. J. Med. Virol. 87:664-674, 2015. (c) 2015 Wiley Periodicals, Inc. C1 [Bodhidatta, Ladaporn; Abente, Eugenio; Neesanant, Pimmnapar; Nakjarung, Kaewkanya; Mason, Carl J.] Armed Forces Res Inst Med Sci, Dept Enter Dis, Bangkok 10400, Thailand. [Sirichote, Pantip; Bunyarakyothin, Gaysorn] Minist Publ Hlth, Dept Med Sci, Nonthaburi, Thailand. [Vithayasai, Niyada] Queen Sirikit Natl Inst Child Hlth, Bangkok, Thailand. RP Bodhidatta, L (reprint author), Armed Forces Res Inst Med Sci, Dept Enter Dis, 315-6 Rajvithi Rd, Bangkok 10400, Thailand. EM LadapornB@afrims.org OI MASON, CARL/0000-0002-3676-2811; Abente, Eugenio/0000-0002-3390-2786 FU Armed Forces Health Surveillance Center, Division of Global Emerging Infections Surveillance and Response System (AFHSC-GEIS) [AFHSC-GEIS] FX Grant sponsor: Armed Forces Health Surveillance Center, Division of Global Emerging Infections Surveillance and Response System (AFHSC-GEIS); Grant number: AFHSC-GEIS. NR 59 TC 8 Z9 8 U1 0 U2 4 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0146-6615 EI 1096-9071 J9 J MED VIROL JI J. Med. Virol. PD APR PY 2015 VL 87 IS 4 BP 664 EP 674 DI 10.1002/jmv.24108 PG 11 WC Virology SC Virology GA CB0EX UT WOS:000349299500017 PM 25649836 ER PT J AU Champagne, V Helfritch, D AF Champagne, V. Helfritch, D. TI Critical Assessment 11: Structural repairs by cold spray SO MATERIALS SCIENCE AND TECHNOLOGY LA English DT Article DE Cold spray; Repair; Critical assessment; Aircraft; Dimensional restoration; Damage; Wear; Corrosion; Remanufacturing ID DEPOSITION; COATINGS AB The deposition of material by cold spray is a relatively new technology. It is often applied to coating applications but can be used for the repair of defects in and damage to metal structures. The use of cold spray for repair is often favoured because, unlike thermal spray methods, cold spray does not bring about heat related damage to the component under repair. The status of the technology and the barriers to widespread commercial application are assessed. The types of repair that have been made with cold spray are discussed, and the unique features of cold spray that permit successful repairs are demonstrated. C1 [Champagne, V.] US Army, Res Lab, Aberdeen Proving Ground, MD USA. [Helfritch, D.] TKC Global, Hearndon, VA 20171 USA. RP Helfritch, D (reprint author), TKC Global, Hearndon, VA 20171 USA. EM Dennis.Helfritch@tkcglobal.com NR 35 TC 9 Z9 9 U1 2 U2 25 PU MANEY PUBLISHING PI LEEDS PA STE 1C, JOSEPHS WELL, HANOVER WALK, LEEDS LS3 1AB, W YORKS, ENGLAND SN 0267-0836 EI 1743-2847 J9 MATER SCI TECH-LOND JI Mater. Sci. Technol. PD APR PY 2015 VL 31 IS 6 BP 627 EP 634 DI 10.1179/1743284714Y.0000000723 PG 8 WC Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Materials Science; Metallurgy & Metallurgical Engineering GA AZ6QE UT WOS:000348343000001 ER PT J AU Day, JB Basavanna, U AF Day, J. B. Basavanna, U. TI Magnetic bead based immuno-detection of Listeria monocytogenes and Listeria ivanovii from infant formula and leafy green vegetables using the Bio-Plex suspension array system SO FOOD MICROBIOLOGY LA English DT Article DE Listeria; Detection; Foods; Macrophage; Bio-Plex ID REAL-TIME PCR; ESCHERICHIA-COLI O157-H7; CELL-CULTURE METHOD; TO-EAT FOODS; UNITED-STATES; EPIDEMIC LISTERIOSIS; SUBSEQUENT DETECTION; OUTBREAK; SALMONELLA; VIRULENCE AB Listeriosis, a disease contracted via the consumption of foods contaminated with pathogenic Listeria species, can produce severe symptoms and high mortality in susceptible people and animals. The development of molecular methods and immuno-based techniques for detection of pathogenic Listeria in foods has been challenging due to the presence of assay inhibiting food components. In this study, we utilize a macrophage cell culture system for the isolation and enrichment of Listeria monocytogenes and Listeria ivanovii from infant formula and leafy green vegetables for subsequent identification using the Luminex xMAP technique. Macrophage monolayers were exposed to infant formula, lettuce and celery contaminated with L. monocytogenes or L. ivanovii. Magnetic microspheres conjugated to Listeria specific antibody were used to capture Listeria from infected macrophages and then analyzed using the Bio-Plex 200 analyzer. As few as 10 CFU/mL or g of L. monocytogenes was detected in all foods tested. The detection limit for L. ivanovii was 10 CFU/mL in infant formula and 100 CFU/g in leafy greens. Microsphere bound Listeria obtained from infected macrophage lysates could also be isolated on selective media for subsequent confirmatory identification. This method presumptively identifies L. monocytogenes and L. ivanovii from infant formula, lettuce and celery in less than 28 h with confirmatory identifications completed in less than 48 h. Published by Elsevier Ltd. C1 [Day, J. B.] US FDA, Ctr Food Safety & Appl Nutr, College Pk, MD 20740 USA. [Basavanna, U.] US Army, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. RP Day, JB (reprint author), US FDA, Ctr Food Safety & Appl Nutr, 5100 Paint Branch Pkwy, College Pk, MD 20740 USA. EM james.day@fda.hhs.gov NR 56 TC 5 Z9 5 U1 4 U2 57 PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD PI LONDON PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND SN 0740-0020 EI 1095-9998 J9 FOOD MICROBIOL JI Food Microbiol. PD APR PY 2015 VL 46 BP 564 EP 572 DI 10.1016/j.fm.2014.09.020 PG 9 WC Biotechnology & Applied Microbiology; Food Science & Technology; Microbiology SC Biotechnology & Applied Microbiology; Food Science & Technology; Microbiology GA AW0OM UT WOS:000345992200070 PM 25475329 ER PT J AU Buonora, JE Yarnell, AM Lazarus, RC Mousseau, M Latour, LL Rizoli, SB Baker, AJ Rhind, SG Diaz-Arrastia, R Mueller, GP AF Buonora, John E. Yarnell, Angela M. Lazarus, Rachel C. Mousseau, Michael Latour, Lawrence L. Rizoli, Sandro B. Baker, Andrew J. Rhind, Shawn G. Diaz-Arrastia, Ramon Mueller, Gregory P. TI Multivariate analysis of traumatic brain injury: development of an assessment score SO FRONTIERS IN NEUROLOGY LA English DT Article DE biomarkers; assessment score; human; mild traumatic brain injury; multivariate analysis ID C-TERMINAL HYDROLASE; FIBRILLARY ACIDIC PROTEIN; NEURON-SPECIFIC ENOLASE; CREATINE-KINASE-BB; MILD HEAD-INJURY; SERUM-LEVELS; CEREBROSPINAL-FLUID; NEUROTROPHIC FACTOR; OXIDATIVE STRESS; ICE HOCKEY AB Important challenges for the diagnosis and monitoring of mild traumatic brain injury (mTBI) include the development of plasma biomarkers for assessing neurologic injury, monitoring pathogenesis, and predicting vulnerability for the development of untoward neurologic outcomes. While several biomarker proteins have shown promise in this regard, used individually, these candidates lack adequate sensitivity and/or specificity for making a definitive diagnosis or identifying those at risk of subsequent pathology. The objective for this study was to evaluate a panel of six recognized and novel biomarker candidates for the assessment of TB I in adult patients. The biomarkers studied were selected on the basis of their relative brain-specificities and potentials to reflect distinct features of TBI mechanisms including (1) neuronal damage assessed by neuron-specific enolase (NSE) and brain derived neurotrophic factor (BDNF); (2) oxidative stress assessed by peroxiredoxin 6 (PRDX6); (3) glial damage and gliosis assessed by glial fibrillary acidic protein and S100 calcium binding protein beta (S100b); (4) immune activation assessed by monocyte chemoattractant protein 1/chemokine (C-C motif) ligand 2 (MCP1/CCL2); and (5) disruption of the intercellular adhesion apparatus assessed by intercellular adhesion protein-5 (ICAM-5). The combined fold-changes in plasma levels of PRDX6, S100b, MCP1, NSE, and BDNF resulted in the formulation of a TBI assessment score that identified mTBI with a receiver operating characteristic (ROC) area under the curve of 0.97, when compared to healthy controls. This research demonstrates that a profile of biomarker responses can be used to formulate a diagnostic score that is sensitive for the detection of mTBI. Ideally, this multivariate assessment strategy will be refined with additional biomarkers that can effectively assess the spectrum of TBI and identify those at particular risk for developing neuropathologies as consequence of a mTBI event. C1 [Buonora, John E.; Lazarus, Rachel C.; Mousseau, Michael; Mueller, Gregory P.] Uniformed Serv Univ Hlth Sci, Dept Anat Physiol & Genet, Bethesda, MD 20814 USA. [Buonora, John E.] US Army, Grad Program Anesthesia Nursing, Acad Hlth Sci, Ft Sam Houston, TX USA. [Yarnell, Angela M.] Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci Res, Behav Biol Branch, Silver Spring, MD USA. [Latour, Lawrence L.] NINDS, Stroke Branch, Bethesda, MD 20892 USA. [Latour, Lawrence L.; Rhind, Shawn G.] Toronto Res Ctr, Def Res & Dev Canada, Toronto, ON, Canada. [Rizoli, Sandro B.; Baker, Andrew J.] Univ Toronto, St Michaels Hosp, Dept Anesthesia, Keenan Res Ctr,Li Ka Shing Knowledge Inst, Toronto, ON, Canada. [Rizoli, Sandro B.; Baker, Andrew J.] Univ Toronto, St Michaels Hosp, Dept Surg, Keenan Res Ctr,Li Ka Shing Knowledge Inst, Toronto, ON, Canada. [Rizoli, Sandro B.; Baker, Andrew J.] Univ Toronto, St Michaels Hosp, Dept Crit Care Med, Keenan Res Ctr,Li Ka Shing Knowledge Inst, Toronto, ON, Canada. [Baker, Andrew J.] Univ Toronto, Cara Phelan Ctr Trauma Res, Brain Injury Lab, Keenan Res Ctr,Li Ka Shing Knowledge Inst, Toronto, ON, Canada. [Diaz-Arrastia, Ramon] Uniformed Serv Univ Hlth Sci, Ctr Neurosci & Regenerat Med, Bethesda, MD 20814 USA. RP Mueller, GP (reprint author), Uniformed Serv Univ Hlth Sci USU, Dept Anat Physiol & Genet, Room C2117,4301 Jones Bridge Rd, Bethesda, MD 20814 USA. EM gregory.mueller@usuhs.edu FU Defense Medical Research and Development; Center for Neuroscience and Regenerative Medicine; TriService Nursing Research Program Grant [HT9404-12-1-TS13]; Department of National Defense of Canada (DND) through the Technology Investment Fund (TIF) program FX Principle source of funding was provided by a grant from the Defense Medical Research and Development, the Center for Neuroscience and Regenerative Medicine and the TriService Nursing Research Program Grant # HT9404-12-1-TS13. The authors also gratefully acknowledge the support of the Department of National Defense of Canada (DND) through the Technology Investment Fund (TIF) program. We also would like to acknowledge Mr. James Freedy for his contribution to the development of the single and multiplex assay platforms; Ms. Maria Shiu and Mr. Alex Di Battista for their technical assistance with sample collection and processing. The opinions expressed here are those of the author(s), and are not necessarily representative of those of the Uniformed Services University of the Health Sciences (USUHS), the United States Army and/or the Department of Defense, USA. NR 67 TC 7 Z9 7 U1 0 U2 1 PU FRONTIERS MEDIA SA PI LAUSANNE PA PO BOX 110, EPFL INNOVATION PARK, BUILDING I, LAUSANNE, 1015, SWITZERLAND SN 1664-2295 J9 FRONT NEUROL JI Front. Neurol. PD MAR 30 PY 2015 VL 6 AR UNSP 68 DI 10.3389/fneur.2015.00068 PG 11 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA CU8EV UT WOS:000363775100001 PM 25870583 ER PT J AU Hunsawong, T Sunintaboon, P Warit, S Thaisomboonsuk, B Jarman, RG Yoon, IK Ubol, S Fernandez, S AF Hunsawong, Taweewun Sunintaboon, Panya Warit, Saradee Thaisomboonsuk, Butsaya Jarman, Richard G. Yoon, In-Kyu Ubol, Sukathida Fernandez, Stefan TI A novel dengue virus serotype-2 nanovaccine induces robust humoral and cell-mediated immunity in mice SO VACCINE LA English DT Article DE Dengue virus; Dengue nanovaccine; Nanoparticle-based vaccine; Immunostimulatory effect; Swiss albino mice ID ENVELOPE DOMAIN III; ANTIBODY-RESPONSE; DENDRITIC CELL; T-CELLS; VACCINE; NANOPARTICLES; INFECTION; ANTIGEN; INDUCTION; EFFICACY AB Dengue virus (DENV), a member of the Flaviviridae family, can be transmitted to humans through the bite of infected Aedes mosquitoes. The incidence of dengue has increased worldwide over the past few decades. Inadequate vector control, changing global ecology, increased urbanization, and faster global travel are factors enhancing the rapid spread of the virus and its vector. In the absence of specific antiviral treatments, the search for a safe and effective vaccine grows more imperative. Many strategies have been utilized to develop dengue vaccines. Here, we demonstrate the immunogenic properties of a novel dengue nanovaccine (DNV), composed of ultraviolet radiation (UV)-inactivated DENV-2, which has been loaded into the nanopartides containing chitosan/Mycobacterium bovis Bacillus Calmette-Guerin cell wall components (CS/BCG-NPs). We investigated the immunogenicity of DNV in a Swiss albino mouse model. Inoculation with various concentrations of vaccine (0.3, 1, 3 and 10 mu g/dose) with three doses, 15-day apart, induced strong anti-dengue IgM and IgG antibodies in the mouse serum along with neutralizing antibody against DENV-2 reference strain (16681), a clinical-isolate strain (00745/10) and the mouse-adapted New Guinea-C (NGC) strain. Cytokine and chemokine secretion in the serum of DNV-immunized mice showed elevated levels of IFN-gamma, IL-2, IL-5, IL-12p40, IL-12p70, IL-17, eotaxin and RANTES, all of which have varying immune functions. Furthermore, we observed a DNV dose-dependent increase in the frequencies of IFN-gamma-producing CD4(+) and CD8(+) T cells after in vitro stimulation of nucleated cells. Based on these findings, DNV has the potential to become a candidate dengue vaccine. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). C1 [Hunsawong, Taweewun; Ubol, Sukathida] Mahidol Univ, Fac Sci, Dept Microbiol, Bangkok 10700, Thailand. [Hunsawong, Taweewun; Thaisomboonsuk, Butsaya; Yoon, In-Kyu; Fernandez, Stefan] Armed Force Res Inst Med Sci, Dept Virol, Bangkok, Thailand. [Sunintaboon, Panya] Mahidol Univ, Fac Sci, Dept Chem, Bangkok 10400, Thailand. [Warit, Saradee] Natl Sci & Technol Dev Agcy, Natl Ctr Genet Engn & Biotechnol, TB Res Lab, Pathum Thani, Thailand. [Jarman, Richard G.] Walter Reed Army Inst Res, Viral Dis Branch, Bethesda, MD USA. RP Ubol, S (reprint author), USAMC AFRIMS, Dept Virol, 315-6 Ratchavithi Rd Payathai, Bangkok, Thailand. EM sukathida.ubo@mahidol.ac.th; Stafan.Fernandez@afrims.org NR 61 TC 5 Z9 5 U1 3 U2 13 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X EI 1873-2518 J9 VACCINE JI Vaccine PD MAR 30 PY 2015 VL 33 IS 14 BP 1702 EP 1710 DI 10.1016/j.vaccine.2015.02.016 PG 9 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA CF6JA UT WOS:000352661800009 PM 25701315 ER PT J AU Ward, CL Sanchez, CJ Pollot, BE Romano, DR Hardy, SK Becerra, SC Rathbone, CR Wenke, JC AF Ward, Catherine L. Sanchez, Carlos J., Jr. Pollot, Beth E. Romano, Desiree R. Hardy, Sharanda K. Becerra, Sandra C. Rathbone, Christopher R. Wenke, Joseph C. TI Soluble factors from biofilms of wound pathogens modulate human bone marrow-derived stromal cell differentiation, migration, angiogenesis, and cytokine secretion SO BMC MICROBIOLOGY LA English DT Article DE Staphylococcus aureus; Pseudomonas aeruginosa; Biofilm; Mesenchymal stromal cells; Wound healing; Differentiation; Angiogenesis ID MESENCHYMAL STEM-CELLS; TOLL-LIKE RECEPTORS; TNF-ALPHA; IN-VITRO; ANTIMICROBIAL PEPTIDE; EXPRESSION; LL-37; KERATINOCYTES; INFLAMMATION; FIBROBLASTS AB Background: Chronic, non-healing wounds are often characterized by the persistence of bacteria within biofilms - aggregations of cells encased within a self-produced polysaccharide matrix. Biofilm bacteria exhibit unique characteristics from planktonic, or culture-grown, bacterial phenotype, including diminished responses to antimicrobial therapy and persistence against host immune responses. Mesenchymal stromal cells (MSCs) are host cells characterized by their multifunctional ability to undergo differentiation into multiple cell types and modulation of host-immune responses by secreting factors that promote wound healing. While these characteristics make MSCs an attractive therapeutic for wounds, these pro-healing activities may be differentially influenced in the context of an infection (i.e., biofilm related infections) within chronic wounds. Herein, we evaluated the effect of soluble factors derived from biofilms of clinical isolates of Staphylococcus aureus and Pseudomonas aeruginosa on the viability, differentiation, and paracrine activity of human MSCs to evaluate the influence of biofilms on MSC activity in vitro. Results: Exposure of MSCs to biofilm-conditioned medias of S. aureus and P. aeruginosa resulted in reductions in cell viability, in part due to activation of apoptosis. Similarly, exposure to soluble factors from biofilms was also observed to diminish the migration ability of cells and to hinder multi-lineage differentiation of MSCs. In contrast to these findings, exposure of MSCs to soluble factors from biofilms resulted in significant increases in the release of paracrine factors involved in inflammation and wound healing. Conclusions: Collectively, these findings demonstrate that factors produced by biofilms can negatively impact the intrinsic properties of MSCs, in particular limiting the migratory and differentiation capacity of MSCs. Consequently, these studies suggest use/application of stem-cell therapies in the context of infection may have a limited therapeutic effect. C1 [Ward, Catherine L.; Sanchez, Carlos J., Jr.; Pollot, Beth E.; Romano, Desiree R.; Hardy, Sharanda K.; Becerra, Sandra C.; Rathbone, Christopher R.; Wenke, Joseph C.] US Army, Inst Surg Res, Dept Extrem Trauma & Regenerat Med, San Antonio, TX 78234 USA. RP Ward, CL (reprint author), US Army, Inst Surg Res, Dept Extrem Trauma & Regenerat Med, San Antonio, TX 78234 USA. EM catherine.l.ward.vol@mail.mil FU Combat Casualty Care Research Program, Medical Research and Materiel Command; Post-doctoral Research Associate Fellowship through the National Academy of Sciences FX This work was supported by intramural funding from the Combat Casualty Care Research Program, Medical Research and Materiel Command to JCW. CLW and CJS are supported by a Post-doctoral Research Associate Fellowship through the National Academy of Sciences. NR 58 TC 8 Z9 8 U1 1 U2 14 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1471-2180 J9 BMC MICROBIOL JI BMC Microbiol. PD MAR 28 PY 2015 VL 15 AR 75 DI 10.1186/s12866-015-0412-x PG 14 WC Microbiology SC Microbiology GA CE5VW UT WOS:000351904800001 PM 25886581 ER PT J AU Akber, A Reed, MW Walker, PM Litvinov, YA Lane, GJ Kibedi, T Blaum, K Bosch, F Brandau, C Carroll, JJ Cullen, DM Cullen, IJ Deo, AY Detwiler, B Dimopoulou, C Dracoulis, GD Farinon, F Geissel, H Haettner, E Heil, M Kempley, RS Knobel, R Kozhuharov, C Kurcewicz, J Kuzminchuk, N Litvinov, S Liu, Z Mao, R Nociforo, C Nolden, F Plass, WR Podolyak, Z Prochazka, A Scheidenberger, C Shubina, D Steck, M Stohlker, T Sun, B Swan, TPD Trees, G Weick, H Winckler, N Winkler, M Woods, PJ Yamaguchi, T AF Akber, A. Reed, M. W. Walker, P. M. Litvinov, Yu. A. Lane, G. J. Kibedi, T. Blaum, K. Bosch, F. Brandau, C. Carroll, J. J. Cullen, D. M. Cullen, I. J. Deo, A. Y. Detwiler, B. Dimopoulou, C. Dracoulis, G. D. Farinon, F. Geissel, H. Haettner, E. Heil, M. Kempley, R. S. Knoebel, R. Kozhuharov, C. Kurcewicz, J. Kuzminchuk, N. Litvinov, S. Liu, Z. Mao, R. Nociforo, C. Nolden, F. Plass, W. R. Podolyak, Zs. Prochazka, A. Scheidenberger, C. Shubina, D. Steck, M. Stoehlker, Th. Sun, B. Swan, T. P. D. Trees, G. Weick, H. Winckler, N. Winkler, M. Woods, P. J. Yamaguchi, T. TI Increased isomeric lifetime of hydrogen-like Os-192m SO PHYSICAL REVIEW C LA English DT Article ID SCHOTTKY MASS-SPECTROMETRY; HEAVY-ION STORAGE; CONVERSION COEFFICIENTS; COOLER RING; ESR; DEPENDENCE; NUCLEI; TRAPS; STATE; FRS AB An excited metastable nuclear state of Os-192 in a hydrogen-like charge state has been studied for the first time. It was populated in projectile fragmentation of a Au-197 beam on a Be-9 target with the UNILAC-SIS accelerators at GSI. Fragmentation products in the region of interest were passed through the fragment separator and injected into the experimental storage ring (ESR). Cooling of the injected beam particles enabled Schottky mass spectrometry to be performed. Analysis shows the lifetime of the state to be considerably longer than that of the neutral ion [tau(neut) = 8.5(14) s]; this change is attributed to hindrance of internal conversion in hydrogen-like Os-192. Calculations have been performed to estimate the lifetime, and the result has been compared with that measured experimentally. There is good agreement between the expected [tau(H-like) = 13.0(24) s] and measured lifetimes (tau(rest) = 15.1(-1.3)(+1.5) s) from the internal decay of Os-192m. This provides a test for the reliability of the values obtained from internal conversion coefficient calculations in highly ionized systems and is the first measurement of its kind to be performed using the ESR setup. C1 [Akber, A.; Reed, M. W.; Lane, G. J.; Kibedi, T.; Dracoulis, G. D.] Australian Natl Univ, Dept Nucl Phys, RSPE, Canberra, ACT 0200, Australia. [Walker, P. M.; Cullen, I. J.; Deo, A. Y.; Kempley, R. S.; Podolyak, Zs.; Swan, T. P. D.] Univ Surrey, Dept Phys, Guildford GU2 7XH, Surrey, England. [Litvinov, Yu. A.; Blaum, K.; Shubina, D.; Winckler, N.] Max Planck Inst Kernphys, D-69117 Heidelberg, Germany. [Litvinov, Yu. A.; Bosch, F.; Dimopoulou, C.; Farinon, F.; Geissel, H.; Heil, M.; Knoebel, R.; Kozhuharov, C.; Kurcewicz, J.; Kuzminchuk, N.; Litvinov, S.; Nociforo, C.; Nolden, F.; Plass, W. R.; Prochazka, A.; Scheidenberger, C.; Steck, M.; Stoehlker, Th.; Weick, H.; Winckler, N.; Winkler, M.] GSI Helmholtzzentrum Schwerionenforsch, D-64291 Darmstadt, Germany. [Brandau, C.] ExtreMe Matter Inst EMMI, D-64291 Darmstadt, Germany. [Brandau, C.] GSI Helmholtzzentrum Schwerionenforsch, Div Res, D-64291 Darmstadt, Germany. [Brandau, C.] Univ Giessen, Inst Atom & Mol Phys, D-35392 Giessen, Germany. [Carroll, J. J.] US Army Res Lab, Adelphi, MD 20783 USA. [Cullen, D. M.] Univ Manchester, Sch Phys & Astron, Schuster Lab, Manchester M13 9PL, Lancs, England. [Detwiler, B.; Trees, G.] Youngstown State Univ, Youngstown, OH 44555 USA. [Geissel, H.; Haettner, E.; Plass, W. R.; Scheidenberger, C.] Univ Giessen, Inst Phys 2, D-35392 Giessen, Germany. [Liu, Z.; Woods, P. J.] Univ Edinburgh, Sch Phys & Astron, Edinburgh EH9 3JZ, Midlothian, Scotland. [Mao, R.] Chinese Acad Sci, Inst Modern Phys, Lanzhou 730000, Peoples R China. [Stoehlker, Th.] Heidelberg Univ, Inst Phys, D-69120 Heidelberg, Germany. [Sun, B.] Beihaug Univ, Sch Phys & Nucl Energy Engn, Beijing 100191, Peoples R China. [Yamaguchi, T.] Saitama Univ, Grad Sch Sci & Engn, Saitama 3388570, Japan. RP Akber, A (reprint author), Australian Natl Univ, Dept Nucl Phys, RSPE, GPO Box 4, Canberra, ACT 0200, Australia. RI Lane, Gregory/A-7570-2011; Sun, Baohua/C-6823-2009 OI Lane, Gregory/0000-0003-2244-182X; Sun, Baohua/0000-0001-9868-5711 FU UK STFC, DTRA(YSU) [HDTRA1-08-1-0014]; Australian Research Council [FT10010099]; BMBF [06GI911I, 06GI7127/05P12R6FAN]; Helmholtz Alliance [HA216/EMMI]; international Max Planck Research School for Precision Test of Fundamental Symmetries at MPIK; NECT; NSFC [11105010]; BMBF Grant in the framework of the Internationale Zusammenarbeit in Bildung und Forschung; Helmholtz/CAS Joint Research Group HCJRG [HCJRG-108]; Japan Society for the Promotion of Science [A19204023]; [WTZ 01DO12012] FX The authors are grateful to the accelerator team for their excellent contribution. This work has been supported by the UK STFC, DTRA(YSU) under Contract No. HDTRA1-08-1-0014, and the Australian Research Council (Grant No. FT10010099). C. Brandau was supported by BMBF (Contract 06GI911I and 06GI7127/05P12R6FAN) and by the Helmholtz Alliance HA216/EMMI. D. Shubina is supported by the international Max Planck Research School for Precision Test of Fundamental Symmetries at MPIK. B. Sun is partially supported by NECT and NSFC 11105010 and by the BMBF Grant in the framework of the Internationale Zusammenarbeit in Bildung und Forschung. Yu. A. Litvinov was supported by WTZ 01DO12012 and Helmholtz/CAS Joint Research Group HCJRG (Group No. HCJRG-108). T. Yamaguchi is grateful for a grant-in-aid for scientific research No. A19204023 by the Japan Society for the Promotion of Science. NR 26 TC 5 Z9 5 U1 2 U2 21 PU AMER PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 2469-9985 EI 2469-9993 J9 PHYS REV C JI Phys. Rev. C PD MAR 27 PY 2015 VL 91 IS 3 AR 031301 DI 10.1103/PhysRevC.91.031301 PG 4 WC Physics, Nuclear SC Physics GA CE3NL UT WOS:000351733200001 ER PT J AU Masters, BC Garvin, TP Mitsingas, CM Ford, KB Marsh, CP AF Masters, B. C. Garvin, T. P. Mitsingas, C. M. Ford, K. B. Marsh, C. P. TI Design and manufacture of a microchannel plasma reactor by CNC milling SO MICROELECTRONIC ENGINEERING LA English DT Article DE Plasma discharge; Microchannel; Microfluidics; Micro milling ID MICROPLASMA; DEVICES; BENDS; FLOW AB Microcavity plasma devices show promise for controlled plasma chemistry. However, these devices are typically made through processes that are difficult to scale up. We present the design and characterization of a microchannel system suitable for the study of microplasmas. The channel was created with a micro-mill CNC machine that allows for quick device manufacturing. The channel is characterized using scanning electron microscopy and profilometry. Finally, we use recently published models of flow in a microchannel with bends to elucidate pressure conditions throughout the channel. Future work will encompass characterization of plasma conditions. (C) 2015 Published by Elsevier B.V. C1 [Masters, B. C.; Mitsingas, C. M.; Ford, K. B.; Marsh, C. P.] US Army Corps Engineers, Engn Res & Dev Ctr, Construct Engn Res Lab, Champaign, IL 61822 USA. [Garvin, T. P.] Univ Illinois, Dept Mech Sci & Engn, Urbana, IL 61801 USA. [Masters, B. C.; Marsh, C. P.] Univ Illinois, Dept Nucl Plasma & Radiol Engn, Urbana, IL 61801 USA. RP Masters, BC (reprint author), US Army Corps Engineers, Engn Res & Dev Ctr, Construct Engn Res Lab, 2902 Newmark Dr, Champaign, IL 61822 USA. EM bcmaster@illinois.edu FU Army Corps of Engineers through US Army Research, Development, Test & Evaluation (RDT&E) Program Element [T23]; Basic Research/Military Construction [10-55]; Fundamental Investigation of Microplasma Gas Reactions at Atmospheric Pressures FX The authors would like to thank Professor S. G. Kapoor (Department of MechSE, University of Illinois) for allowing the use of the micro CNC machine. This investigation was funded by the Army Corps of Engineers through US Army Research, Development, Test & Evaluation (RDT&E) Program Element T23, "Basic Research/Military Construction"; Project 10-55, "Fundamental Investigation of Microplasma Gas Reactions at Atmospheric Pressures." This research was supported in part by an appointment to the Postgraduate Research Participation Program at the US Army Engineer Research and Development Center, Construction Engineering Research Laboratory, administered by the Oak Ridge Institute for Science and Education (ORISE) through an interagency agreement between the US Department of Energy and US Army ERDC-CERL. This work was carried out in part in the Frederick Seitz Materials Research Laboratory Central Research Facilities, University of Illinois at Urbana-Champaign. NR 13 TC 1 Z9 1 U1 2 U2 21 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0167-9317 EI 1873-5568 J9 MICROELECTRON ENG JI Microelectron. Eng. PD MAR 25 PY 2015 VL 136 BP 51 EP 56 DI 10.1016/j.mee.2015.03.052 PG 6 WC Engineering, Electrical & Electronic; Nanoscience & Nanotechnology; Optics; Physics, Applied SC Engineering; Science & Technology - Other Topics; Optics; Physics GA CI8LI UT WOS:000355023400010 ER PT J AU Lai, LL Davey, R Beck, A Xu, YX Suffredini, AF Palmore, T Kabbani, S Rogers, S Kobinger, G Alimonti, J Link, CJ Rubinson, L Stroher, U Wolcott, M Dorman, W Uyeki, TM Feldmann, H Lane, HC Mulligan, MJ AF Lai, Lilin Davey, Richard Beck, Allison Xu, Yongxian Suffredini, Anthony F. Palmore, Tara Kabbani, Sarah Rogers, Susan Kobinger, Gary Alimonti, Judie Link, Charles J., Jr. Rubinson, Lewis Stroeher, Ute Wolcott, Mark Dorman, William Uyeki, Timothy M. Feldmann, Heinz Lane, H. Clifford Mulligan, Mark J. TI Emergency Postexposure Vaccination With Vesicular Stomatitis Virus-Vectored Ebola Vaccine After Needlestick SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION LA English DT Article ID NONHUMAN-PRIMATES; MONOCLONAL-ANTIBODIES; PROTECTION; INFECTION; FEVER AB IMPORTANCE Safe and effective vaccines and drugs are needed for the prevention and treatment of Ebola virus disease, including following a potentially high-risk exposure such as a needlestick. OBJECTIVE To assess response to postexposure vaccination in a health care worker who was exposed to the Ebola virus. DESIGN AND SETTING Case report of a physician who experienced a needlestick while working in an Ebola treatment unit in Sierra Leone on September 26, 2014. Medical evacuation to the United States was rapidly initiated. Given the concern about potentially lethal Ebola virus disease, the patient was offered, and provided his consent for, postexposure vaccination with an experimental vaccine available through an emergency Investigational New Drug application. He was vaccinated on September 28, 2014. INTERVENTIONS The vaccine used was VSV Delta G-ZEBOV, a replicating, attenuated, recombinant vesicular stomatitis virus (serotype Indiana) whose surface glycoprotein gene was replaced by the Zaire Ebola virus glycoprotein gene. This vaccine has entered a clinical trial for the prevention of Ebola in West Africa. RESULTS The vaccine was administered 43 hours after the needlestick occurred. Fever and moderate to severe symptoms developed 12 hours after vaccination and diminished over 3 to 4 days. The real-time reverse transcription polymerase chain reaction results were transiently positive for vesicular stomatitis virus nucleoprotein gene and Ebola virus glycoprotein gene (both included in the vaccine) but consistently negative for Ebola virus nucleoprotein gene (not in the vaccine). Early postvaccination cytokine secretion and T lymphocyte and plasmablast activation were detected. Subsequently, Ebola virus glycoprotein-specific antibodies and T cells became detectable, but antibodies against Ebola viral matrix protein 40 (not in the vaccine) were not detected. CONCLUSIONS AND RELEVANCE It is unknown if VSV Delta G-ZEBOV is safe or effective for postexposure vaccination in humans who have experienced a high-risk occupational exposure to the Ebola virus, such as a needlestick. In this patient, postexposure vaccination with VSV Delta G-ZEBOV induced a self-limited febrile syndrome that was associated with transient detection of the recombinant vesicular stomatitis vaccine virus in blood. Strong innate and Ebola-specific adaptive immune responses were detected after vaccination. The clinical syndrome and laboratory evidence were consistent with vaccination response, and no evidence of Ebola virus infection was detected. C1 [Lai, Lilin; Beck, Allison; Xu, Yongxian; Kabbani, Sarah; Rogers, Susan; Mulligan, Mark J.] Emory Univ, Sch Med, Dept Med, Emory Vaccine Ctr,Div Infect Dis,Hope Clin, Atlanta, GA USA. [Davey, Richard; Suffredini, Anthony F.; Palmore, Tara; Lane, H. Clifford] NIAID, Div Clin Res, Ctr Clin, NIH, Bethesda, MD 20892 USA. [Kobinger, Gary; Alimonti, Judie] Publ Hlth Agcy Canada, Natl Lab Zoonot Dis & Special Pathogens, Winnipeg, MB, Canada. [Link, Charles J., Jr.] NewLink Genet Corp, Ames, IA USA. [Rubinson, Lewis] Univ Maryland, Sch Med, Div Trauma Crit Care, R Adams Cowley Shock Trauma Ctr, Baltimore, MD 21201 USA. [Stroeher, Ute; Uyeki, Timothy M.] US Ctr Dis Control & Prevent, Atlanta, GA USA. [Wolcott, Mark; Dorman, William] US Army, Diagnost Syst Div, Med Res Inst Infect Dis, Frederick, MD USA. [Feldmann, Heinz] NIAID, Div Intramural Res, Virol Lab, NIH, Hamilton, MT USA. RP Mulligan, MJ (reprint author), Emory Univ, Hope Clin, Emory Vaccine Ctr, 500 Irvin Ct,Ste 200, Decatur, GA 30030 USA. EM mark.mulligan@emory.edu FU Georgia Research Alliance and Emory University; National Center for Advancing Translational Sciences of the National Institutes of Health [UL1TR000454]; Emory Vaccinology Training Program under the National Institute of Allergy and Infectious Diseases, National Institutes of Health [T32AI074492]; National Institute of Allergy and Infectious Diseases Intramural Research Program at the National Institutes of Health FX This work was supported in part by the Georgia Research Alliance and Emory University (Dr Mulligan); the National Center for Advancing Translational Sciences of the National Institutes of Health (award UL1TR000454); the Emory Vaccinology Training Program under the National Institute of Allergy and Infectious Diseases, National Institutes of Health (T32AI074492 awarded to Drs Kabbani and Mulligan); and the National Institute of Allergy and Infectious Diseases Intramural Research Program at the National Institutes of Health. NR 20 TC 32 Z9 33 U1 0 U2 45 PU AMER MEDICAL ASSOC PI CHICAGO PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA SN 0098-7484 EI 1538-3598 J9 JAMA-J AM MED ASSOC JI JAMA-J. Am. Med. Assoc. PD MAR 24 PY 2015 VL 313 IS 12 BP 1249 EP 1255 DI 10.1001/jama.2015.1995 PG 7 WC Medicine, General & Internal SC General & Internal Medicine GA CD9RJ UT WOS:000351435500024 PM 25742465 ER PT J AU Collier, ZA Kennedy, AJ Poda, AR Cuddy, MF Moser, RD MacCuspie, RI Harmon, A Plourde, K Haines, CD Steevens, JA AF Collier, Zachary A. Kennedy, Alan J. Poda, Aimee R. Cuddy, Michael F. Moser, Robert D. MacCuspie, Robert I. Harmon, Ashley Plourde, Kenton Haines, Christopher D. Steevens, Jeffery A. TI Tiered guidance for risk-informed environmental health and safety testing of nanotechnologies SO JOURNAL OF NANOPARTICLE RESEARCH LA English DT Article DE Nano; Environmental health and safety; Release; Hazard; Risk; Regulatory ID ECOTOXICITY TEST METHODS; SILVER NANOPARTICLES; DAPHNIA-MAGNA; SURFACE-AREA; CATEGORIZATION FRAMEWORK; ENGINEERED NANOMATERIALS; CONSUMER PRODUCTS; AQUATIC ORGANISMS; CARBON NANOTUBES; OXIDATIVE STRESS AB Provided the rapid emergence of novel technologies containing engineered nanomaterials, there is a need to better understand the potential environmental, health, and safety effects of nanotechnologies before wide-scale deployment. However, the unique properties of nanomaterials and uncertainty regarding applicable test methods have led to a lack of consensus regarding the collection and evaluation of data related to hazard and exposure potentials. Often, overly conservative approaches to characterization and data collection result in prolonged, unfocused, or irrelevant testing, which increases costs and delays deployment. In this paper, we provide a novel testing guidance framework for determining whether a nanotechnology has the potential to release material with nano-specific parameters that pose a risk to humans or the environment. The framework considers methods to categorize nanotechnologies by their structure and within their relevant-use scenarios to inform testing in a time-and resource-limited reality. Based on the precedent of dredged sediment testing, a five-tiered approach is proposed in which opportunities are presented to conclude testing once sufficient risk-related information has been collected, or that the technology in question does not require nano-specific scrutiny. A series of screening stages are suggested, covering relevant aspects including size, surface area, distribution, unique behaviors, and release potential. The tiered, adaptive guidance approach allows users to concentrate on collecting the most relevant data, thus accelerating technology deployment while minimizing risk. C1 [Collier, Zachary A.; Kennedy, Alan J.; Poda, Aimee R.; Cuddy, Michael F.; Moser, Robert D.; Harmon, Ashley; Plourde, Kenton; Steevens, Jeffery A.] US Army Engn Res & Dev Ctr, Vicksburg, MS 39180 USA. [MacCuspie, Robert I.] Florida Polytech Univ, Lakeland, FL 33805 USA. [Haines, Christopher D.] US Army Armament Res Dev & Engn Ctr, Picatinny Arsenal, NJ 07806 USA. RP Kennedy, AJ (reprint author), US Army Engn Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM alan.j.kennedy@usace.army.mil RI Poda, Aimee/K-1905-2012 FU Army Environmental Quality and Installations (EQI) Technology Research Program FX Permission was granted by the US Army Corps of Engineers, Chief of Engineers to publish this material. The views expressed in this article are solely those of the authors and do not reflect the official policies or positions of the Department of Army, the Department of Defense, or any other department or agency of the U.S. government. Mention of trade names or commercial products does not constitute endorsement or recommendation for use. This work was funded through the Army Environmental Quality and Installations (EQI) Technology Research Program (Dr. Elizabeth Ferguson, Technical Director) for the U.S Army Engineer Research and Development Center (ERDC). NR 117 TC 4 Z9 4 U1 3 U2 21 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 1388-0764 EI 1572-896X J9 J NANOPART RES JI J. Nanopart. Res. PD MAR 21 PY 2015 VL 17 IS 3 AR 155 DI 10.1007/s11051-015-2943-3 PG 21 WC Chemistry, Multidisciplinary; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary SC Chemistry; Science & Technology - Other Topics; Materials Science GA CI8JE UT WOS:000355017800001 ER PT J AU Guo, W Kirste, R Bryan, Z Bryan, I Gerhold, M Collazo, R Sitar, Z AF Guo, Wei Kirste, Ronny Bryan, Zachary Bryan, Isaac Gerhold, Michael Collazo, Ramon Sitar, Zlatko TI Nanostructure surface patterning of GaN thin films and application to AlGaN/AlN multiple quantum wells: A way towards light extraction efficiency enhancement of III-nitride based light emitting diodes SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID ANODIC POROUS ALUMINA; PHOTONIC CRYSTAL; GROWTH; LEDS; ALN AB Enhanced light extraction efficiency was demonstrated on nanostructure patterned GaN and AlGaN/AlN Multiple-Quantum-Well (MQW) structures using mass production techniques including natural lithography and interference lithography with feature size as small as 100 nm. Periodic nanostructures showed higher light extraction efficiency and modified emission profile compared to non-periodic structures based on integral reflection and angular-resolved transmission measurement. Light extraction mechanism of macroscopic and microscopic nanopatterning is discussed, and the advantage of using periodic nanostructure patterning is provided. An enhanced photoluminescence emission intensity was observed on nanostructure patterned AlGaN/AlN MQW compared to as-grown structure, demonstrating a large-scale and mass-producible pathway to higher light extraction efficiency in deep-ultra-violet light-emitting diodes. (C) 2015 AIP Publishing LLC. C1 [Guo, Wei; Kirste, Ronny; Bryan, Zachary; Bryan, Isaac; Collazo, Ramon; Sitar, Zlatko] N Carolina State Univ, Dept Mat Sci & Engn, Raleigh, NC 27695 USA. [Gerhold, Michael] Army Res Off, Engn Sci Directorate, Res Triangle Pk, NC 27703 USA. RP Guo, W (reprint author), N Carolina State Univ, Dept Mat Sci & Engn, Box 7907, Raleigh, NC 27695 USA. EM wguo2@ncsu.edu FU NSF [DMR-1108071, DMR-1312582]; ARO [W911NF-04-D-0003]; ARL [W911QX-10-C-0027] FX The authors would like to acknowledge partial financial support from the NSF (DMR-1108071 and DMR-1312582), ARO (W911NF-04-D-0003), and ARL (W911QX-10-C-0027). The authors would like to thank Dr. Jinqiao Xie of HexaTech (currently at TriQuint Semiconductor) for initial fruitful discussions. All of the AlN wafers used for growth of MQWs were supplied by HexaTech, Inc., Morrisville, North Carolina, www.hexatechinc.com. NR 38 TC 2 Z9 2 U1 4 U2 38 PU AMER INST PHYSICS PI MELVILLE PA 1305 WALT WHITMAN RD, STE 300, MELVILLE, NY 11747-4501 USA SN 0021-8979 EI 1089-7550 J9 J APPL PHYS JI J. Appl. Phys. PD MAR 21 PY 2015 VL 117 IS 11 AR 113107 DI 10.1063/1.4915903 PG 8 WC Physics, Applied SC Physics GA CE1WZ UT WOS:000351604900022 ER PT J AU Engler, RJM Nelson, MR Collins, LC Spooner, C Hemann, BA Gibbs, BT Atwood, JE Howard, RS Chang, AS Cruser, DL Gates, DG Vernalis, MN Lengkeek, MS McClenathan, BM Jaffe, AS Cooper, LT Black, S Carlson, C Wilson, C Davis, RL AF Engler, Renata J. M. Nelson, Michael R. Collins, Limone C., Jr. Spooner, Christina Hemann, Brian A. Gibbs, Barnett T. Atwood, J. Edwin Howard, Robin S. Chang, Audrey S. Cruser, Daniel L. Gates, Daniel G. Vernalis, Marina N. Lengkeek, Marguerite S. McClenathan, Bruce M. Jaffe, Allan S. Cooper, Leslie T. Black, Steve Carlson, Christopher Wilson, Christopher Davis, Robert L. TI A Prospective Study of the Incidence of Myocarditis/Pericarditis and New Onset Cardiac Symptoms following Smallpox and Influenza Vaccination SO PLOS ONE LA English DT Article ID INDUCED MYOCARDIAL-ISCHEMIA; LONG-TERM MORTALITY; TROPONIN-T; ADVERSE EVENTS; UNITED-STATES; GENERAL-POPULATION; RISK; ELEVATION; EXERCISE; RECOMMENDATIONS AB Background Although myocarditis/pericarditis (MP) has been identified as an adverse event following smallpox vaccine (SPX), the prospective incidence of this reaction and new onset cardiac symptoms, including possible subclinical injury, has not been prospectively defined. Purpose The study's primary objective was to determine the prospective incidence of new onset cardiac symptoms, clinical and possible subclinical MP in temporal association with immunization. Methods New onset cardiac symptoms, clinical MP and cardiac specific troponin T (cTnT) elevations following SPX (above individual baseline values) were measured in a multi-center prospective, active surveillance cohort study of healthy subjects receiving either smallpox vaccine or trivalent influenza vaccine (TIV). Results New onset chest pain, dyspnea, and/or palpitations occurred in 10.6% of SPX-vaccinees and 2.6% of TIV-vaccinees within 30 days of immunization (relative risk (RR) 4.0, 95% CI: 1.7-9.3). Among the 1081 SPX-vaccinees with complete follow-up, 4 Caucasian males were diagnosed with probable myocarditis and 1 female with suspected pericarditis. This indicates a post-SPX incidence rate more than 200-times higher than the pre-SPX background population surveillance rate of myocarditis/pericarditis (RR 214, 95% CI 65-558). Additionally, 31 SPX-vaccinees without specific cardiac symptoms were found to have over 2-fold increases in cTnT (>99th percentile) from baseline (pre-SPX) during the window of risk for clinical myocarditis/pericarditis and meeting a proposed case definition for possible subclinical myocarditis. This rate is 60-times higher than the incidence rate of overt clinical cases. No clinical or possible subclinical myocarditis cases were identified in the TIV-vaccinated group. Conclusions Passive surveillance significantly underestimates the true incidence of myocarditis/pericarditis after smallpox immunization. Evidence of subclinical transient cardiac muscle injury post-vaccinia immunization is a finding that requires further study to include long-term outcomes surveillance. Active safety surveillance is needed to identify adverse events that are not well understood or previously recognized. C1 [Engler, Renata J. M.; Collins, Limone C., Jr.; Spooner, Christina] Walter Reed Natl Mil Med Ctr, Immunizat Healthcare Branch, Def Hlth Agcy, Mil Vaccine Agcy Vaccine Healthcare Ctr Network, Bethesda, MD 20889 USA. [Engler, Renata J. M.; Nelson, Michael R.] Uniformed Serv Univ Hlth Sci, Dept Med & Pediat, Bethesda, MD 20814 USA. [Nelson, Michael R.] Walter Reed Natl Mil Med Ctr, Allergy Immunol Immunizat, Bethesda, MD USA. [Hemann, Brian A.; Gibbs, Barnett T.; Atwood, J. Edwin] Walter Reed Natl Mil Med Ctr, Dept Med, Serv Cardiol, Bethesda, MD USA. [Hemann, Brian A.; Gibbs, Barnett T.; Atwood, J. Edwin] Uniformed Serv Univ Hlth Sci, Dept Med, Bethesda, MD 20814 USA. [Howard, Robin S.; Chang, Audrey S.] Walter Reed Natl Mil Med Ctr, Dept Res Programs, Bethesda, MD USA. [Cruser, Daniel L.] Vassar Bros Med Ctr, Dept Pathol, Poughkeepsie, NY USA. [Gates, Daniel G.] Ft Belvoir Community Hosp, Serv Cardiol, Ft Belvoir, VA USA. [Vernalis, Marina N.] Walter Reed Natl Mil Med Ctr, Integrated Cardiac Hlth Project, Bethesda, MD USA. [Lengkeek, Marguerite S.] Allergy & Asthma Care Ctr, Chantilly, VA USA. [McClenathan, Bruce M.] Womack Army Med Ctr, Def Hlth Agcy, Immunizat Healthcare Branch, Mil Vaccine Agcy Vaccine Healthcare Ctr Network, Ft Bragg, NC USA. [Jaffe, Allan S.; Cooper, Leslie T.] Mayo Clin, Div Cardiovasc Dis, Rochester, MN USA. [Black, Steve] Cincinnati Childrens Hosp Ctr Global Hlth, Cincinnati, OH USA. [Carlson, Christopher] Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Seattle, WA 98104 USA. [Wilson, Christopher] Univ Washington, Dept Immunol, Seattle, WA 98195 USA. [Davis, Robert L.] Univ Tennessee, Ctr Hlth Sci, Ctr Biomed Informat, Memphis, TN 38163 USA. [Davis, Robert L.] Oak Ridge Natl Lab, Oak Ridge, TN USA. RP Engler, RJM (reprint author), Walter Reed Natl Mil Med Ctr, Immunizat Healthcare Branch, Def Hlth Agcy, Mil Vaccine Agcy Vaccine Healthcare Ctr Network, Bethesda, MD 20889 USA. EM renata.engler@gmail.com FU Centers for Disease Control and Prevention [200-2002-00732]; National Institute of Allergy and Infectious Disease Population Genetics Program [N01 AI40069]; Federal funds from the National Institute of Allergies and Infectious Diseases, National Institutes of Health, Department of Health and Human Services [HHSN272201000024C] FX This study was supported by the Vaccine Healthcare Centers Network and Allergy-Immunology, Walter Reed Army Medical Center (Bethesda, MD)/Military Vaccine Agency, Office of the Army Surgeon General, Clinical Immunization Safety Assessment Network (Atlanta, GA) (subcontract with America's Health Insurance Plans under contract 200-2002-00732 from the Centers for Disease Control and Prevention), National Institute of Allergy and Infectious Disease Population Genetics Program (N01 AI40069). This project has been funded in part with Federal funds from the National Institute of Allergies and Infectious Diseases, National Institutes of Health, Department of Health and Human Services, under Contract No. HHSN272201000024C. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 50 TC 5 Z9 5 U1 0 U2 6 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD MAR 20 PY 2015 VL 10 IS 3 AR e0118283 DI 10.1371/journal.pone.0118283 PG 18 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA CE8IA UT WOS:000352084200018 PM 25793705 ER PT J AU Warfield, KL Dye, JM Wells, JB Unfer, RC Holtsberg, FW Shulenin, S Vu, H Swenson, DL Bavari, S Aman, MJ AF Warfield, Kelly L. Dye, John M. Wells, Jay B. Unfer, Robert C. Holtsberg, Frederick W. Shulenin, Sergey Vu, Hong Swenson, Dana L. Bavari, Sina Aman, M. Javad TI Homologous and Heterologous Protection of Nonhuman Primates by Ebola and Sudan Virus-Like Particles SO PLOS ONE LA English DT Article ID MARBURG VIRUSES; INSECT CELLS; GUINEA-PIGS; INFECTION; VACCINE; CHALLENGE; ANTIBODIES; IMMUNIZATION; RESPONSES; MUCOSAL AB Filoviruses cause hemorrhagic fever resulting in significant morbidity and mortality in humans. Several vaccine platforms that include multiple virus-vectored approaches and virus-like particles (VLPs) have shown efficacy in nonhuman primates. Previous studies have shown protection of cynomolgus macaques against homologous infection for Ebola virus (EBOV) and Marburg virus (MARV) following a three-dose vaccine regimen of EBOV or MARV VLPs, as well as heterologous protection against Ravn Virus (RAVV) following vaccination with MARV VLPs. The objectives of the current studies were to determine the minimum number of vaccine doses required for protection (using EBOV as the test system) and then demonstrate protection against Sudan virus (SUDV) and Tai Forest virus (TAFV). Using the EBOV nonhuman primate model, we show that one or two doses of VLP vaccine can confer protection from lethal infection. VLPs containing the SUDV glycoprotein, nucleoprotein and VP40 matrix protein provide complete protection against lethal SUDV infection in macaques. Finally, we demonstrate protective efficacy mediated by EBOV, but not SUDV, VLPs against TAFV; this is the first demonstration of complete cross-filovirus protection using a single component heterologous vaccine within the Ebolavirus genus. Along with our previous results, this observation provides strong evidence that it will be possible to develop and administer a broad-spectrum VLP-based vaccine that will protect against multiple filoviruses by combining only three EBOV, SUDV and MARV components. C1 [Warfield, Kelly L.; Unfer, Robert C.; Holtsberg, Frederick W.; Shulenin, Sergey; Vu, Hong; Aman, M. Javad] Integrated Biotherapeut Inc, Gaithersburg, MD USA. [Dye, John M.; Wells, Jay B.; Swenson, Dana L.; Bavari, Sina] US Army Med Res Inst Infect Dis, Ft Detrick, MD USA. RP Warfield, KL (reprint author), Unither Virol LLC, Silver Spring, MD 20910 USA. EM kwarfield@unithervirology.com FU Federal funds from the National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Health and Human Services [HHSN272200800055C]; Defense Threat Reduction Agency JSTO-CBD; Medical Research and Material Command; Integrated Biotherapeutics FX This project has been funded in part with Federal funds from the National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Health and Human Services, under Contract No. HHSN272200800055C to MJA (IBT) and support from the Defense Threat Reduction Agency JSTO-CBD and the Medical Research and Material Command to JMD and SB (USAMRIID). Integrated Biotherapeutics provided support in the form of salaries for authors KLW, RCU, FWH, SS, HV, and MJA but did not have any additional role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. The specific roles of these authors are articulated in the 'author contributions' section. NR 42 TC 12 Z9 12 U1 1 U2 12 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD MAR 20 PY 2015 VL 10 IS 3 AR e0118881 DI 10.1371/journal.pone.0118881 PG 16 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA CE8IA UT WOS:000352084200043 PM 25793502 ER PT J AU Amani, M Burke, RA Proie, RM Dubey, M AF Amani, Matin Burke, Robert A. Proie, Robert M. Dubey, Madan TI Flexible integrated circuits and multifunctional electronics based on single atomic layers of MoS2 and graphene SO NANOTECHNOLOGY LA English DT Article DE flexible electronics; integrated circuits; MoS2; graphene; heterostructures ID FIELD-EFFECT TRANSISTORS; CHEMICAL-VAPOR-DEPOSITION; CARBON NANOTUBE; MONOLAYER; FILMS; GROWTH AB Two-dimensional materials, such as graphene and its analogues, have been investigated by numerous researchers for high performance flexible and conformal electronic systems, because they offer the ultimate level of thickness scaling, atomically smooth surfaces and high crystalline quality. Here, we use layer-by-layer transfer of large area molybdenum disulphide (MoS2) and graphene grown by chemical vapor deposition (CVD) to demonstrate electronics on flexible polyimide (PI) substrates. On the same PI substrate, we are able to simultaneously fabricate MoS2 based logic, non-volatile memory cells with graphene floating gates, photo-detectors and MoS2 transistors with tunable source and drain contacts. We are also able to demonstrate that these flexible heterostructure devices have very high electronic performance, comparable to four point measurements taken on SiO2 substrates, with on/off ratios > 10(7) and field effect mobilities as high as 16.4 cm(2) V-1 s(-1). Additionally, the heterojunctions show high optoelectronic sensitivity and were operated as photodetectors with responsivities over 30 AW(-1). Through local gating of the individual graphene/MoS2 contacts, we are able to tune the contact resistance over the range of 322-1210 ohm mm for each contact, by modulating the graphene work function. This leads to devices with tunable and multifunctional performance that can be implemented in a conformable platform. C1 [Amani, Matin; Burke, Robert A.; Proie, Robert M.; Dubey, Madan] US Army, Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA. RP Amani, M (reprint author), Univ Calif Berkeley, Elect Engn & Comp Sci, Berkeley, CA 94720 USA. EM madan.dubey.civ@mail.mil FU US Army Research Lab (ARL) FX The authors acknowledge the support of the US Army Research Lab (ARL) Director's Strategic Initiative (DSI) program on interfaces in stacked 2D atomic layered materials. The authors would also like to thank Dr Pani Varanasi of the Army Research Office for his in-depth technical discussion on 2D atomic layers R and D. The views and conclusions contained in this document are those of the authors and should not be interpreted as representing the official policies, either expressed or implied, of the ARL or the US Government. The US Government is authorized to reproduce or distribute reprints for Government purposes notwithstanding any copyright notation herein. NR 34 TC 11 Z9 11 U1 11 U2 194 PU IOP PUBLISHING LTD PI BRISTOL PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND SN 0957-4484 EI 1361-6528 J9 NANOTECHNOLOGY JI Nanotechnology PD MAR 20 PY 2015 VL 26 IS 11 AR 115202 DI 10.1088/0957-4484/26/11/115202 PG 8 WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied SC Science & Technology - Other Topics; Materials Science; Physics GA CC7SO UT WOS:000350568900005 PM 25709100 ER PT J AU Kim, H Wu, FX Lee, JT Nitta, N Lin, HT Oschatz, M Cho, WI Kaskel, S Borodin, O Yushin, G AF Kim, Hyea Wu, Feixiang Lee, Jung Tae Nitta, Naoki Lin, Huan-Ting Oschatz, Martin Cho, Won Il Kaskel, Stefan Borodin, Oleg Yushin, Gleb TI In Situ Formation of Protective Coatings on Sulfur Cathodes in Lithium Batteries with LiFSI-Based Organic Electrolytes SO ADVANCED ENERGY MATERIALS LA English DT Article DE dissolution; cathodes; batteries; electrolytes; protective coatings ID LI-S BATTERIES; RECHARGEABLE BATTERIES; PERFORMANCE; CARBON; CELLS; STABILITY; SALT; TEMPERATURE; PARTICLES; CAPACITY AB Development of sulfur cathodes with 100% coulombic efficiency (CE) and good cycle stability remains challenging due to the polysulfide dissolution in electrolytes. Here, it is demonstrated that electrochemical reduction of lithium bis(fluorosulfonyl)imide (LiFSI) based electrolytes at a potential close to the sulfur cathode operation forms in situ protective coating on both cathode and anode surfaces. Quantum chemistry studies suggest the coating formation is initiated by the FSI(-F) anion radicals generated during electrolyte reduction. Such a reduction additionally results in the formation of LiF. Accelerated cycle stability tests at 60 degrees C in a very simple electrolyte (LiFSI in dimethoxyethane with no additives) show an average CE approaching 100.0% over 1000 cycles with a capacity decay less than 0.013% per cycle after stabilization. Such a remarkable performance suggests a great promise of both an in situ formation of protective solid electrolyte coatings to avoid unwanted side reactions and the use of a LiFSI salt for this purpose. C1 [Kim, Hyea; Wu, Feixiang; Lee, Jung Tae; Nitta, Naoki; Lin, Huan-Ting; Yushin, Gleb] Georgia Inst Technol, Sch Mat Sci & Engn, Atlanta, GA 30332 USA. [Kim, Hyea] Sila Nanotechnol Inc, Atlanta, GA 30332 USA. [Wu, Feixiang] Cent S Univ, Sch Met & Environm, Changsha 410083, Hunan, Peoples R China. [Oschatz, Martin; Kaskel, Stefan] Tech Univ Dresden, Dept Inorgan Chem, D-01069 Dresden, Germany. [Cho, Won Il] Korea Inst Sci & Technol, Ctr Energy Convergence, Seoul 130650, South Korea. [Borodin, Oleg] Army Res Lab, Electrochem Branch, Adelphi, MD 20783 USA. RP Yushin, G (reprint author), Georgia Inst Technol, Sch Mat Sci & Engn, Atlanta, GA 30332 USA. EM yushin@gatech.edu RI Oschatz, Martin/B-1239-2015; Yushin, Gleb/B-4529-2013; Borodin, Oleg/B-6855-2012; OI Yushin, Gleb/0000-0002-3274-9265; Borodin, Oleg/0000-0002-9428-5291; Kaskel, Stefan/0000-0003-4572-0303 FU US Army Research Office [W911NF-12-1-0259]; Energy Efficiency & Resources program of the Korea Institute of Energy Technology Evaluation and Planning (KETEP) - Korea government Ministry of Knowledge Economy [20118510010030]; project "Nanomaterials for future generation Lithium Sulphur batteries" ("MaLiSu") FX Different aspects of this work were supported by the US Army Research Office (grant W911NF-12-1-0259) and by the Energy Efficiency & Resources program of the Korea Institute of Energy Technology Evaluation and Planning (KETEP) funded by the Korea government Ministry of Knowledge Economy (grant 20118510010030). The authors from Dresden University of Technology gratefully acknowledge financial support by the project "Nanomaterials for future generation Lithium Sulphur batteries" ("MaLiSu"). NR 40 TC 32 Z9 32 U1 26 U2 193 PU WILEY-V C H VERLAG GMBH PI WEINHEIM PA BOSCHSTRASSE 12, D-69469 WEINHEIM, GERMANY SN 1614-6832 EI 1614-6840 J9 ADV ENERGY MATER JI Adv. Energy Mater. PD MAR 18 PY 2015 VL 5 IS 6 AR 1401792 DI 10.1002/aenm.201401792 PG 8 WC Chemistry, Physical; Energy & Fuels; Materials Science, Multidisciplinary; Physics, Applied; Physics, Condensed Matter SC Chemistry; Energy & Fuels; Materials Science; Physics GA CE1ZZ UT WOS:000351613200016 ER PT J AU Bradfute, SB Anthony, SM Stuthman, KS Ayithan, N Tailor, P Shaia, CI Bray, M Ozato, K Bavari, S AF Bradfute, Steven B. Anthony, Scott M. Stuthman, Kelly S. Ayithan, Natarajan Tailor, Prafullakumar Shaia, Carl I. Bray, Mike Ozato, Keiko Bavari, Sina TI Mechanisms of Immunity in Post-Exposure Vaccination against Ebola Virus Infection SO PLOS ONE LA English DT Article ID PROTECTS NONHUMAN-PRIMATES; T-CELL RESPONSES; MARBURG HEMORRHAGIC-FEVER; DENDRITIC CELLS; GUINEA-PIGS; CRYPTOCOCCUS-NEOFORMANS; FILOVIRUS INFECTION; MOUSE MODEL; PATHOGENESIS; ANTIBODIES AB Ebolaviruses can cause severe hemorrhagic fever that is characterized by rapid viral replication, coagulopathy, inflammation, and high lethality rates. Although there is no clinically proven vaccine or treatment for Ebola virus infection, a virus-like particle (VLP) vaccine is effective in mice, guinea pigs, and non-human primates when given pre-infection. In this work, we report that VLPs protect Ebola virus-infected mice when given 24 hours post-infection. Analysis of cytokine expression in serum revealed a decrease in pro-inflammatory cytokine and chemokine levels in mice given VLPs post-exposure compared to infected, untreated mice. Using knockout mice, we show that VLP-mediated post-exposure protection requires perforin, B cells, macrophages, conventional dendritic cells (cDCs), and either CD4+ or CD8+ T cells. Protection was Ebola virus-specific, as marburgvirus VLPs did not protect Ebola virus-infected mice. Increased antibody production in VLP-treated mice correlated with protection, and macrophages were required for this increased production. However, NK cells, IFN-gamma, and TNF-alpha were not required for post-exposure-mediated protection. These data suggest that a non-replicating Ebola virus vaccine can provide post-exposure protection and that the mechanisms of immune protection in this setting require both increased antibody production and generation of cytotoxic T cells. C1 [Bradfute, Steven B.; Anthony, Scott M.; Stuthman, Kelly S.; Shaia, Carl I.; Bavari, Sina] US Army Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. [Ayithan, Natarajan; Ozato, Keiko] NICHHD, Lab Mol Growth Regulat, NIH, Bethesda, MD 20892 USA. [Tailor, Prafullakumar] Natl Inst Immunol, New Delhi 110067, India. [Bray, Mike] NIAID, Div Clin Res, NIH, Bethesda, MD 20892 USA. RP Bavari, S (reprint author), US Army Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. EM sina.bavari.civ@mail.mil FU Defense Threat Reduction Agency [1.1C003_08_RD_B] FX This work was supported by a grant from the Defense Threat Reduction Agency to SB (1.1C003_08_RD_B). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 69 TC 3 Z9 3 U1 0 U2 15 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD MAR 18 PY 2015 VL 10 IS 3 AR UNSP e0118434 DI 10.1371/journal.pone.0118434 PG 21 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA CE9BN UT WOS:000352138500034 PM 25785602 ER PT J AU Carr, W Yarnell, AM Ong, R Walilko, T Kamimori, GH da Silva, U McCarron, RM LoPresti, ML AF Carr, Walter Yarnell, Angela M. Ong, Ricardo Walilko, Timothy Kamimori, Gary H. da Silva, Uade McCarron, Richard M. LoPresti, Matthew L. TI Ubiquitin carboxy-terminal hydrolase-L1 as a serum neurotrauma biomarker for exposure to occupational low-level blast SO FRONTIERS IN NEUROLOGY LA English DT Article DE biomarker; blast; military; neurotrauma; breacher ID TRAUMATIC BRAIN-INJURY; NEUROPSYCHOLOGICAL ASSESSMENT METRICS; CEREBROSPINAL-FLUID; ACUTE CONCUSSION; MILD; DISORDERS; SYMPTOMS; BLOOD; L1 AB Repeated exposure to low-level blast is a characteristic of a few select occupations and there is concern that such occupational exposures present risk for traumatic brain injury. These occupations include specialized military and law enforcement units that employ controlled detonation of explosive charges for the purpose of tactical entry into secured structures. The concern for negative effects from blast exposure is based on rates of operator self-reported headache, sleep disturbance, working memory impairment, and other concussion-like symptoms. A challenge in research on this topic has been the need for improved assessment tools to empirically evaluate the risk associated with repeated exposure to blast overpressure levels commonly considered to be too low in magnitude to cause acute injury. Evaluation of serum-based neurotrauma biomarkers provides an objective measure that is logistically feasible for use in field training environments. Among candidate biomarkers, ubiquitin carboxy-terminal hydrolase-L1 (UCH-L1) has some empirical support and was evaluated in this study. We used daily blood draws to examine acute change in UCH-L1 among 108 healthy military personnel who were exposed to repeated low-level blast across a 2-week period. These research volunteers also wore pressure sensors to record blast exposures, wrist actigraphs to monitor sleep patterns, and completed daily behavioral assessments of symptomology, postural stability, and neurocognitive function. UCH-L1 levels were elevated as a function of participating in the 2-week training with explosives, but the correlation of UCH-L1 elevation and blast magnitude was weak and inconsistent. Also, UCH-L1 elevations did not correlate with deficits in behavioral measures. These results provide some support for including UCH-L1 as a measure of central nervous system effects from exposure to low-level blast. However, the weak relation observed suggests that additional indicators of blast effect are needed. C1 [Carr, Walter; Yarnell, Angela M.; Kamimori, Gary H.; LoPresti, Matthew L.] Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci, Silver Spring, MD 20910 USA. [Ong, Ricardo] US Army Special Forces Command, Ft Bragg, NC USA. [Walilko, Timothy] Appl Res Associates Inc, Littleton, CO USA. [da Silva, Uade; McCarron, Richard M.] Walter Reed Army Inst Res, NeuroTrauma Dept, Silver Spring, MD 20910 USA. RP Carr, W (reprint author), Walter Reed Army Inst Res, Dept Behav Biol, Ctr Mil Psychiat & Neurosci, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM walter.s.carr.mil@mail.mil FU US Army Medical Research and Materiel Command; US Navy Bureau of Medicine; US Army Special Operations Command; US Army Engineer School FX This work was supported by the US Army Medical Research and Materiel Command and the US Navy Bureau of Medicine. We thank the members of the study team who helped collect and process the data: SGT Ashlie Strickland-Mangano, SGT Benjamin Joiner, SPC George Adams, SSG Kelly McWhirter, SGT Shawn McLoughlin, SSG Dominic Prankienas, SGT Robert Catalano, SGT Reginald Acklin, HM3 Eric Cho, Luke Aurich, Dan Welsh, Brandon Peterson, Zach Gates, Stephanie Eonta, Carmen Contreras-Sesvold, and David Miles. We also thank the leadership from the US Army Special Operations Command and US Army Engineer School for their support and the Soldiers of the units studied for their service to our nation and their participation in the study. NR 39 TC 1 Z9 1 U1 1 U2 2 PU FRONTIERS MEDIA SA PI LAUSANNE PA PO BOX 110, EPFL INNOVATION PARK, BUILDING I, LAUSANNE, 1015, SWITZERLAND SN 1664-2295 J9 FRONT NEUROL JI Front. Neurol. PD MAR 16 PY 2015 VL 6 AR UNSP 49 DI 10.3389/fneur.2015.00049 PG 11 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA CU8CX UT WOS:000363769900002 PM 25852633 ER PT J AU Morimont, P Batchinsky, A Lambermont, B AF Morimont, Philippe Batchinsky, Andriy Lambermont, Bernard TI Update on the role of extracorporeal CO2 removal as an adjunct to mechanical ventilation in ARDS SO CRITICAL CARE LA English DT Review ID RESPIRATORY-DISTRESS-SYNDROME; CARBON-DIOXIDE REMOVAL; INDUCED LUNG INJURY; POSITIVE-PRESSURE VENTILATION; TIDAL VOLUME REDUCTION; PERMISSIVE HYPERCAPNIA; LIFE-SUPPORT; 6 ML/KG; ACIDOSIS; FAILURE AB This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency Medicine 2015 and co-published as a series in Critical Care. Other articles in the series can be found online at http://ccforum.com/series/annualupdate2015. Further information about the Annual Update in Intensive Care and Emergency Medicine is available from http://www.springer.com/series/8901. C1 [Morimont, Philippe; Lambermont, Bernard] Univ Hosp Liege, Dept Internal Med, Med & Coronary Intens Care Unit, Liege, Belgium. [Batchinsky, Andriy] US Army Inst Surg Res, Battlefield Hlth & Trauma Res Inst, San Antonio, TX USA. RP Morimont, P (reprint author), Univ Hosp Liege, Dept Internal Med, Med & Coronary Intens Care Unit, Liege, Belgium. EM ph.morimont@chu.ulg.ac.be FU Maquet FX PM and BL have received supply of equipment (CO2 removal device, medical disposables) and funding by Maquet for an experimental study on extracorporeal CO2 removal theapy in 2013 and 2014. PM and AB have received travel and lodging support for conferences. NR 48 TC 4 Z9 5 U1 0 U2 1 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1466-609X EI 1364-8535 J9 CRIT CARE JI Crit. Care PD MAR 16 PY 2015 VL 19 AR 117 DI 10.1186/s13054-015-0799-7 PG 7 WC Critical Care Medicine SC General & Internal Medicine GA CE7PE UT WOS:000352033000001 PM 25888428 ER PT J AU Saguil, A Fargo, M Grogan, S AF Saguil, Aaron Fargo, Matthew Grogan, Scott TI Diagnosis and Management of Kawasaki Disease SO AMERICAN FAMILY PHYSICIAN LA English DT Article ID CORONARY-ARTERY ABNORMALITIES; EPIDEMIOLOGY; EFFICACY; PREVALENCE; INFLIXIMAB; CHILDREN; THERAPY; HEALTH AB Kawasaki disease is an acute, systemic vasculitis that predominantly affects patients younger than five years. It represents the most prominent cause of acquired coronary artery disease in childhood. In the United States, 19 per 100,000 children younger than five years are hospitalized with Kawasaki disease annually. According to U.S. and Japanese guidelines, Kawasaki disease is a clinical diagnosis. Classic (typical) Kawasaki disease is diagnosed based on the presence of a fever lasting five or more days, accompanied by four out of five findings: bilateral conjunctival injection, oral changes such as cracked and erythematous lips and strawberry tongue, cervical lymphadenopathy, extremity changes such as erythema or palm and sole desquamation, and polymorphous rash. Incomplete (atypical) Kawasaki disease occurs in persons with fever lasting five or more days and with two or three of these findings. Transthoracic echocardiography is the diagnostic imaging modality of choice to screen for coronary aneurysms, although other techniques are being evaluated for diagnosis and management. Treatment for acute disease is intravenous immunoglobulin and aspirin. If there is no response to treatment, patients are given a second dose of intravenous immunoglobulin with or without corticosteroids or other adjunctive treatments. The presence and severity of coronary aneurysms and obstruction at diagnosis determine treatment options and the need, periodicity, and intensity of long-term cardiovascular monitoring for potential atherosclerosis. Copyright (C) 2015 American Academy of Family Physicians. C1 [Saguil, Aaron] Uniformed Serv Univ Hlth Sci, F Edward Hebert Sch Med, Recruitment & Admiss, Bethesda, MD 20814 USA. [Fargo, Matthew] Dwight D Eisenhower Army Med Ctr, Family Med Residency Program, Ft Gordon, GA USA. [Grogan, Scott] Dwight D Eisenhower Army Med Ctr, Family Med Residency Program, Fac Dev & Res, Ft Gordon, GA USA. RP Saguil, A (reprint author), Dewitt Army Community Hosp, 9501 Farrell Rd, Ft Belvoir, VA 22060 USA. EM aaron.saguil@usuhs.edu NR 28 TC 1 Z9 1 U1 1 U2 7 PU AMER ACAD FAMILY PHYSICIANS PI KANSAS CITY PA 8880 WARD PARKWAY, KANSAS CITY, MO 64114-2797 USA SN 0002-838X EI 1532-0650 J9 AM FAM PHYSICIAN JI Am. Fam. Physician PD MAR 15 PY 2015 VL 91 IS 6 BP 365 EP 371 PG 7 WC Primary Health Care; Medicine, General & Internal SC General & Internal Medicine GA CD8GO UT WOS:000351333400008 PM 25822554 ER PT J AU Gauer, RL Semidey, MJ AF Gauer, Robert L. Semidey, Michael J. TI Diagnosis and Treatment of Temporomandibular Disorders SO AMERICAN FAMILY PHYSICIAN LA English DT Article ID RANDOMIZED CONTROLLED-TRIALS; BOTULINUM-TOXIN; FACIAL-PAIN; INTERNAL DERANGEMENT; PHYSICAL-THERAPY; CLINICAL-TRIAL; OROFACIAL PAIN; JOINT PAIN; MANAGEMENT; ACUPUNCTURE AB Temporomandibular disorders (TMD) are a heterogeneous group of musculoskeletal and neuromuscular conditions involving the temporomandibular joint complex, and surrounding musculature and osseous components. TMD affects up to 15% of adults, with a peak incidence at 20 to 40 years of age. TMD is classified as intra-articular or extra-articular. Common symptoms include jaw pain or dysfunction, earache, headache, and facial pain. The etiology of TMD is multifactorial and includes biologic, environmental, social, emotional, and cognitive triggers. Diagnosis is most often based on history and physical examination. Diagnostic imaging may be beneficial when malocclusion or intra-articular abnormalities are suspected. Most patients improve with a combination of noninvasive therapies, including patient education, self-care, cognitive behavior therapy, pharmacotherapy, physical therapy, and occlusal devices. Nonsteroidal anti-inflammatory drugs and muscle relaxants are recommended initially, and benzodiazepines or antidepressants may be added for chronic cases. Referral to an oral and maxillofacial surgeon is indicated for refractory cases. Copyright (C) 2015 American Academy of Family Physicians. C1 [Gauer, Robert L.; Semidey, Michael J.] Womack Army Med Ctr, Ft Bragg, NC 28310 USA. RP Gauer, RL (reprint author), Womack Army Med Ctr, Riley Rd,Bldg 4-2817, Ft Bragg, NC 28310 USA. EM robertgauer@yahoo.com NR 64 TC 4 Z9 4 U1 2 U2 14 PU AMER ACAD FAMILY PHYSICIANS PI KANSAS CITY PA 8880 WARD PARKWAY, KANSAS CITY, MO 64114-2797 USA SN 0002-838X EI 1532-0650 J9 AM FAM PHYSICIAN JI Am. Fam. Physician PD MAR 15 PY 2015 VL 91 IS 6 BP 378 EP 386 PG 9 WC Primary Health Care; Medicine, General & Internal SC General & Internal Medicine GA CD8GO UT WOS:000351333400010 PM 25822556 ER PT J AU Short, N Hu, SW Gurram, P Gurton, K Chan, A AF Short, Nathaniel Hu, Shuowen Gurram, Prudhvi Gurton, Kristan Chan, Alex TI Improving cross-modal face recognition using polarimetric imaging SO OPTICS LETTERS LA English DT Article AB We investigate the performance of polarimetric imaging in the long-wave infrared (LWIR) spectrum for cross-modal face recognition. For this work, polarimetric imagery is generated as stacks of three components: the conventional thermal intensity image (referred to as S-0), and the two Stokes images, S-1 and S-2, which contain combinations of different polarizations. The proposed face recognition algorithm extracts and combines local gradient magnitude and orientation information from S-0, S-1, and S-2 to generate a robust feature set that is well-suited for cross-modal face recognition. Initial results show that polarimetric LWIR-to-visible face recognition achieves an 18% increase in Rank-1 identification rate compared to conventional LWIR-to-visible face recognition. We conclude that a substantial improvement in automatic face recognition performance can be achieved by exploiting the polarization-state of radiance, as compared to using conventional thermal imagery. (C) 2015 Optical Society of America C1 [Short, Nathaniel; Hu, Shuowen; Gurram, Prudhvi; Gurton, Kristan; Chan, Alex] US Army Res Lab, Adelphi, MD 20783 USA. [Short, Nathaniel] Booz Allen & Hamilton Inc, Mclean, VA 22102 USA. [Gurram, Prudhvi] MBO Partners, Herndon, VA 20171 USA. RP Short, N (reprint author), US Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM nathaniel.j.short2.ctr@mail.mil NR 10 TC 5 Z9 5 U1 1 U2 8 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 0146-9592 EI 1539-4794 J9 OPT LETT JI Opt. Lett. PD MAR 15 PY 2015 VL 40 IS 6 BP 882 EP 885 DI 10.1364/OL.40.000882 PG 4 WC Optics SC Optics GA CD4MI UT WOS:000351056500009 PM 25768137 ER PT J AU Johnson, JB Gelvin, AB Duvoy, P Schaefer, GL Poole, G Horton, GD AF Johnson, Jerome B. Gelvin, Arthur B. Duvoy, Paul Schaefer, Garry L. Poole, Garry Horton, Glenn D. TI Performance characteristics of a new electronic snow water equivalent sensor in different climates SO HYDROLOGICAL PROCESSES LA English DT Article DE snow water equivalent; electronic sensor; hydrology; field measurements; snow pillow AB The US Army ERDC CRREL and the US Department of Agriculture Natural Resources Conservation Service developed a square electronic snow water equivalent (e-SWE) sensor as an alternative to using fluid-filled snow pillows to measure SWE. The sensors consist of a centre panel to measure SWE and eight outer panels to buffer edge stress concentrations. Seven 3m square e-SWE sensors were installed in five different climate zones. During the 2011-2012 winter, 1.8 and 1.2m square e-SWE sensors were installed and operated in Oregon. With the exception of New York State and Newfoundland, the e-SWE sensors accurately measured SWE, with R-2 values between the sensor and manual SWE measurements of between 0.86 and 0.98. The e-SWE sensor at Hogg Pass, Oregon, accurately measured SWE during the past 8years of operations. In the thin, icy snow of New York during midwinter 2008-2009, the e-SWE sensors overmeasured SWE because of edge stress concentrations associated with strong icy layers and a shallow snow cover. The New York e-SWE sensors' measurement accuracy improved in spring 2009 and further improved during the 2011-2012 winter with operating experience. At Santiam Junction, measured SWE from the 1.8 and 1.2m square e-SWE sensors agreed well with the snow pillow, 3m square e-SWE sensor, and manual SWE measurements until February 2013, when dust and gravel blew onto the testing area resulting in anomalous measurements. (c) 2014 The Authors. Hydrological Processes published by John Wiley & Sons Ltd. C1 [Johnson, Jerome B.; Duvoy, Paul] Univ Alaska Fairbanks, Inst Northern Engn, Fairbanks, AK 99775 USA. [Gelvin, Arthur B.] US Army ERDC Cold Reg Res & Engn Lab, Ft Wainwright, AK 99703 USA. [Schaefer, Garry L.] Nat Resources Conservat Serv, USDA, Portland, OR 97232 USA. [Poole, Garry] Newfoundland & Labrador Hydro, St John, NF A1B 4K7, Canada. [Horton, Glenn D.] New York City Environm Protect, Grahamsville, NY 12740 USA. RP Johnson, JB (reprint author), Univ Alaska Fairbanks, Inst Northern Engn, POB 755910, Fairbanks, AK 99775 USA. EM jerome.b.johnson@alaska.edu FU USDA NRCS; Institute of Northern Engineering, University of Alaska Fairbanks FX This work was supported by the USDA NRCS and the Institute of Northern Engineering, University of Alaska Fairbanks. We gratefully acknowledge the SnowNet project (http://www.ipysnow.net/) for using their preliminary SWE data for Barrow and Imnavait. NR 30 TC 1 Z9 1 U1 1 U2 5 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0885-6087 EI 1099-1085 J9 HYDROL PROCESS JI Hydrol. Process. PD MAR 15 PY 2015 VL 29 IS 6 BP 1418 EP 1433 DI 10.1002/hyp.10211 PG 16 WC Water Resources SC Water Resources GA CC7LD UT WOS:000350548100047 ER PT J AU Tao, L Cinquanta, E Chiappe, D Grazianetti, C Fanciulli, M Dubey, M Molle, A Akinwande, D AF Tao, Li Cinquanta, Eugenio Chiappe, Daniele Grazianetti, Carlo Fanciulli, Marco Dubey, Madan Molle, Alessandro Akinwande, Deji TI Silicene field-effect transistors operating at room temperature SO NATURE NANOTECHNOLOGY LA English DT Article ID ELECTRONIC-PROPERTIES; AG(111); NANORIBBONS; GRAPHENE; LAYERS AB Free-standing silicene, a silicon analogue of graphene, has a buckled honeycomb lattice(1) and, because of its Dirac bandstructure(2,3) combined with its sensitive surface, offers the potential for a widely tunable two-dimensional monolayer, where external fields and interface interactions can be exploited to influence fundamental properties such as bandgap(4) and band character(5) for future nanoelectronic devices(6,7). The quantum spin Hall effect(3), chiral superconductivity(8), giant magnetoresistance(9) and various exotic field-dependent states7 have been predicted in monolayer silicene. Despite recent progress regarding the epitaxial synthesis of silicene(8-10) and investigation of its electronic properties(11,13-15), to date there has been no report of experimental silicene devices because of its air stability issue(16). Here, we report a silicene field-effect transistor, corroborating theoretical expectations regarding its ambipolar Dirac charge transport(17), with a measured roomtemperature mobility of similar to 100 cm(2) V-1 s(-1) attributed to acoustic phonon-limited transport(18) and grain boundary scattering. These results are enabled by a growth-transfer-fabrication process that we have devised-silicene encapsulated delamination with native electrodes. This approach addresses a major challenge for material preservation of silicene during transfer and device fabrication and is applicable to other air-sensitive two-dimensional materials such as germanene(2-4) and phosphorene(19,20). Silicene's allotropic affinity with bulk silicon and its low-temperature synthesis compared with graphene or alternative two-dimensional semiconductors suggest a more direct integration with ubiquitous semiconductor technology. C1 [Tao, Li; Akinwande, Deji] Univ Texas Austin, Microelect Res Ctr, Austin, TX 78758 USA. [Cinquanta, Eugenio; Chiappe, Daniele; Grazianetti, Carlo; Fanciulli, Marco; Molle, Alessandro] IMM CNR, Lab MDM, I-20864 Agrate Brianza, Italy. [Dubey, Madan] US Army Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20723 USA. RP Molle, A (reprint author), IMM CNR, Lab MDM, Via C Olivetti 2, I-20864 Agrate Brianza, Italy. EM alessandro.molle@mdm.imm.cnr.it; deji@ece.utexas.edu RI Tao, Li/D-3622-2012; Fanciulli, Marco/J-9940-2013; Molle, Alessandro/D-8952-2013; Cinquanta, Eugenio/J-7747-2016 OI Grazianetti, Carlo/0000-0003-0060-9804; Tao, Li/0000-0001-6055-6068; Fanciulli, Marco/0000-0003-2951-0859; Molle, Alessandro/0000-0002-3860-4120; Cinquanta, Eugenio/0000-0002-4721-5215 FU Army Research Office [W911NF-13-1-0364]; Southwest Academy of Nanoelectronics (SWAN) centre - Semiconductor Research Corporation (SRC); Future and Emerging Technologies (FET) programme within the Seventh Framework Program for Research of the European Commission (FET) [270749]; TI/Jack Kilby Faculty Fellowship FX This work is supported in part by the Army Research Office (contract W911NF-13-1-0364), the Southwest Academy of Nanoelectronics (SWAN) centre sponsored by the Semiconductor Research Corporation (SRC) and the Future and Emerging Technologies (FET) programme within the Seventh Framework Program for Research of the European Commission (FET-Open grant number 270749, '2D-Nanolattices' project). D.A. acknowledges the TI/Jack Kilby Faculty Fellowship. The authors thank A. Nayak and J. Wozniak of Texas Advanced Computing Centre (TACC) for their help with the three-dimensional rendering of Figure 1. NR 34 TC 280 Z9 287 U1 87 U2 462 PU NATURE PUBLISHING GROUP PI LONDON PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND SN 1748-3387 EI 1748-3395 J9 NAT NANOTECHNOL JI Nat. Nanotechnol. PD MAR 15 PY 2015 VL 10 IS 3 BP 227 EP 231 DI 10.1038/NNANO.2014.325 PG 5 WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary SC Science & Technology - Other Topics; Materials Science GA CD0YG UT WOS:000350799700012 PM 25643256 ER PT J AU Hanrahan, B Misra, S Waits, CM Ghodssi, R AF Hanrahan, Brendan Misra, Saswat Waits, C. Mike Ghodssi, Reza TI Wear mechanisms in microfabricated ball bearing systems SO WEAR LA English DT Article DE Rolling friction; Micro-abrasion; Galling; Bearings; Surface analysis ID MICROBALL BEARINGS; PHASE-TRANSFORMATIONS; SILICON; FRICTION; MEMS; LUBRICATION; INDENTATION; TEMPERATURE; DESIGN AB Microfabricated ball bearings have been demonstrated successfully in a number of microsystems, although a complete understanding of their tribological properties remains elusive. This paper investigates the wear mechanisms for a microfabricated ball bearing platform that includes silicon and thin-film coated silicon raceway/steel ball materials systems. Adhesion of ball material, found to be the primary wear mechanism, is universally present in all tested materials systems. Volumetric adhesive wear rates are observed between 4 x 10(-4) and 4 x 10(-5) mu m(3)/mN.rev. Pressured-induced phase changes take place in the contact areas of the bare silicon raceways, observed with Raman spectroscopy. An understanding of the wear mechanisms within microfabricated ball bearings will help optimize operational parameters and materials systems for long-term reliability. (C) 2015 Elsevier B.V. All rights reserved. C1 [Hanrahan, Brendan] Univ Maryland, Mat Sci & Engn Dept, College Pk, MD 20704 USA. [Misra, Saswat; Ghodssi, Reza] Univ Maryland, Syst Res Inst, Elect & Comp Engn Dept, College Pk, MD 20704 USA. [Waits, C. Mike] US Army, Res Lab, Adelphi, MD 20783 USA. RP Ghodssi, R (reprint author), Univ Maryland, Syst Res Inst, Elect & Comp Engn Dept, 2173 AV Williams Bldg, College Pk, MD 20704 USA. EM ghodssi@umd.edu FU U.S. National Science Foundation [0901411] FX This work was supported by the U.S. National Science Foundation under award No. 0901411. We would also like to acknowledge the Maryland Nanocenter and the U.S. Army Research Laboratory Cleanroom Staff. NR 35 TC 4 Z9 4 U1 5 U2 42 PU ELSEVIER SCIENCE SA PI LAUSANNE PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND SN 0043-1648 EI 1873-2577 J9 WEAR JI Wear PD MAR 15 PY 2015 VL 326 BP 1 EP 9 DI 10.1016/j.wear.2014.12.032 PG 9 WC Engineering, Mechanical; Materials Science, Multidisciplinary SC Engineering; Materials Science GA CD2VP UT WOS:000350937400001 ER PT J AU Palomino, JM Tran, DT Kareh, AR Miller, CA Gardner, JMV Dong, H Oliver, SRJ AF Palomino, Jessica M. Tran, Dat T. Kareh, Ana R. Miller, Christopher A. Gardner, Joshua M. V. Dong, Hong Oliver, Scott R. J. TI Zirconia-silica based mesoporous desulfurization adsorbents SO JOURNAL OF POWER SOURCES LA English DT Article DE Mesoporous silica; Desulfurization; JP-8 jet fuel; Adsorbents ID DEEP DESULFURIZATION; ADSORPTIVE DESULFURIZATION; SELECTIVE ADSORPTION; JET FUEL; ROOM-TEMPERATURE; PARTICLE-SIZE; DIESEL FUEL; CATALYSTS; GASOLINE; SULFUR AB We report a series of mesoporous silicate sorbent materials templated by long-chain primary alkyl-amines that display record level of desulfurization of the jet fuel JP-8. Pure silica frameworks and those with a Si:Zr synthesis molar ratio ranging from 44:1 to 11:1 were investigated. The optimum sorbent was identified as dodecylamine-templated silica-zirconia synthesized from a gel with Si:Zr molar ratio of 15:1. With an optimized silver loading of 11 wt.%, a saturation adsorption capacity of 39.4 mgS g(-1) and a silver efficiency of 1.21 moIS mol Ag-1 were observed for JP-8. This sorbent displayed exceptional regenerability, maintaining 86% of its initial capacity in model fuel after solvent regeneration with diethyl ether. Low-cost, portable and reusable sorbents for the desulfurization of JP-8 jet fuel are needed to make solid oxide fuel cells (SOFCs) a reality for military power needs. SOFCs require ultra-low sulfur content fuel, which traditional desulfurization methods cannot achieve. (C) 2014 Elsevier B.V. All rights reserved. C1 [Palomino, Jessica M.; Kareh, Ana R.; Miller, Christopher A.; Gardner, Joshua M. V.; Oliver, Scott R. J.] Univ Calif Santa Cruz, Dept Chem & Biochem, Santa Cruz, CA 95064 USA. [Tran, Dat T.] US Army, Res Lab, Adelphi, MD 20783 USA. [Dong, Hong] US Army, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Tran, DT (reprint author), Univ Calif Santa Cruz, Dept Chem & Biochem, Santa Cruz, CA 95064 USA. EM dat.t.tran4.civ@mail.mil; soliver@ucsc.edu OI Vecchione Gardner, Joshua/0000-0003-4386-0628 FU DOD ARL [W911NF-12-2-0005] FX This work was supported by DOD ARL, Contract No. W911NF-12-2-0005. We acknowledge Dr. Tom Yuzvinsky for image acquisition and the W.M. Keck Center for Nanoscale Optofluidics at UC Santa Cruz for use of the FEI Quanta 3D Dualbeam microscope. NR 32 TC 8 Z9 9 U1 6 U2 44 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0378-7753 EI 1873-2755 J9 J POWER SOURCES JI J. Power Sources PD MAR 15 PY 2015 VL 278 BP 141 EP 148 DI 10.1016/j.jpowsour.2014.12.043 PG 8 WC Chemistry, Physical; Electrochemistry; Energy & Fuels; Materials Science, Multidisciplinary SC Chemistry; Electrochemistry; Energy & Fuels; Materials Science GA CC2NH UT WOS:000350181400018 ER PT J AU Kalambate, PK Dar, RA Karna, SP Srivastava, AK AF Kalambate, Pramod K. Dar, Riyaz A. Karna, Shashi P. Srivastava, Ashwini K. TI High performance supercapacitor based on graphene-silver nanoparticles-polypyrrole nanocomposite coated on glassy carbon electrode (vol 276, pg 262, 2014) SO JOURNAL OF POWER SOURCES LA English DT Correction C1 [Kalambate, Pramod K.; Dar, Riyaz A.; Srivastava, Ashwini K.] Univ Mumbai, Dept Chem, Bombay 400098, Maharashtra, India. [Karna, Shashi P.] US Army Res Lab, Weap & Mat Res Directorate, ATTN RDRL WM, Aberdeen Proving Ground, MD 21005 USA. RP Srivastava, AK (reprint author), Univ Mumbai, Dept Chem, Bombay 400098, Maharashtra, India. EM aksrivastava@chem.mu.ac.in NR 1 TC 2 Z9 2 U1 10 U2 76 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0378-7753 EI 1873-2755 J9 J POWER SOURCES JI J. Power Sources PD MAR 15 PY 2015 VL 278 BP 828 EP 828 DI 10.1016/j.jpowsour.2014.12.114 PG 1 WC Chemistry, Physical; Electrochemistry; Energy & Fuels; Materials Science, Multidisciplinary SC Chemistry; Electrochemistry; Energy & Fuels; Materials Science GA CC2NH UT WOS:000350181400099 ER PT J AU Whipps, GT Ertin, E Moses, RL AF Whipps, Gene T. Ertin, Emre Moses, Randolph L. TI Distributed Detection of Binary Decisions with Collisions in a Large, Random Network SO IEEE TRANSACTIONS ON SIGNAL PROCESSING LA English DT Article DE Binary sensors; distributed detection; local vote; point process; random access; random sensor network ID SENSOR NETWORKS AB We consider the problem of distributed detection in a large network of sensors. A random number of sensor nodes are randomly deployed. Sensor nodes perform local detection tests and communicate detections over a multiple-access channel to a fusion center. The fusion center can recognize both successful communications and communication collisions in the channel. We derive decision rules for both perfect communications and a delay-constrained communications protocol, and show that each are functions of count statistics only. We derive analytical expressions that characterize the performance of the system in terms of detection performance. We analyze performance with respect to sensor density and with respect to communications delay. Simulation examples validate theoretical predictions with numerical results. We show that the detection performance improves with network density despite increasing communication collisions. In addition, we show that detection performance using the protocol model, with imperfect communications, rapidly converges to the perfect communications case as the number of communication slots increase. C1 [Whipps, Gene T.] US Army Res Lab, Adelphi, MD 20783 USA. [Whipps, Gene T.; Ertin, Emre; Moses, Randolph L.] Ohio State Univ, Dept Elect & Comp Engn, Columbus, OH 43210 USA. RP Whipps, GT (reprint author), US Army Res Lab, Adelphi, MD 20783 USA. EM whipps.8@osu.edu; ertin.1@osu.edu; moses.2@osu.edu FU U.S. Army Research Laboratory; ARO [W911NF-11-1-0391] FX Date of publication February 06, 2015; date of current version February 13, 2015. The associate editor coordinating the review of this manuscript and approving it for publication was. The research reported here was partially supported by the U.S. Army Research Laboratory and by a grant from ARO, W911NF-11-1-0391. NR 13 TC 3 Z9 3 U1 0 U2 2 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1053-587X EI 1941-0476 J9 IEEE T SIGNAL PROCES JI IEEE Trans. Signal Process. PD MAR 15 PY 2015 VL 63 IS 6 BP 1477 EP 1489 DI 10.1109/TSP.2015.2398843 PG 13 WC Engineering, Electrical & Electronic SC Engineering GA CC0SL UT WOS:000350046600010 ER PT J AU Query, PR AF Query, Patrick R. TI Never Let Me Go and the Horizons of the Novel SO CRITIQUE-STUDIES IN CONTEMPORARY FICTION LA English DT Article DE Never Let Me Go; the novel; Kazuo Ishiguro; Jose Ortega y Gasset; acceptance AB This essay examines Kazuo Ishiguro's Never Let Me Go as a metaphor for novel reading. It addresses in particular the main characters' abiding and troubling acceptance of their circumstances. It uses the theories of Jose Ortega y Gasset and Walter Benjamin to build the argument that, by thematizing acceptance, Never Let Me Go demonstrates the reader's own nearly automatic practice of assenting to the created world of a novel. C1 US Mil Acad, West Point, NY 10996 USA. RP Query, PR (reprint author), US Mil Acad, West Point, NY 10996 USA. NR 12 TC 0 Z9 0 U1 0 U2 11 PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND SN 0011-1619 EI 1939-9138 J9 CRITIQUE-ST CONTEMP JI Crit.-Stud. Contemp. Fiction PD MAR 15 PY 2015 VL 56 IS 2 BP 155 EP 172 DI 10.1080/00111619.2013.868339 PG 18 WC Literature SC Literature GA CC0PA UT WOS:000350036800003 ER PT J AU Ghoshal, A Ayers, J Gurvich, M Urban, M Bordick, N AF Ghoshal, Anindya Ayers, James Gurvich, Mark Urban, Michael Bordick, Nathaniel TI Experimental investigations in embedded sensing of composite components in aerospace vehicles SO COMPOSITES PART B-ENGINEERING LA English DT Article DE Laminated composites; Polymer matrix composites (PMCs); Non-destructive testing; Delamination; Optical properties/techniques ID DELAMINATION DETECTION; FIBEROPTIC SENSORS; GRATING SENSORS; PATCHES; IMPACT AB This paper summarizes the experimental investigations for smart embedded sensing in rotorcraft composite components. The overall objective of this effort was to develop smart embedded sensor technologies for condition based maintenance (CBM) for composite components in army rotorcraft. This paper presents the results of experimental investigations related to development and maturation of different types of embedded sensing solutions for structural health monitoring of composite components including Fiber Bragg Grating (FBG) sensors, phased and discrete piezoelectric sensor arrays. A discussion is provided relative to embedment of optical fibers into composites, and the results from embedded FBG sensors in a rotorcraft flexbeam subcomponent test specimen with seeded delamination subjected to dynamic loading. Likewise, results are analyzed of surface mounted phased array and embedded smart piezoelectric sensors in the flexbeam subcomponent test specimen with embedded delamination, subjected to fatigue cyclic loading. The paper also summarizes the lessons learned from efforts to nucleate and propagate delamination within composite components under dynamic cyclic loading. Published by Elsevier Ltd. C1 [Ghoshal, Anindya] US Army, Res Lab, Vehicle Technol Directorate, Aberdeen Proving Ground, MD 21005 USA. [Ayers, James] Honeywell Aerosp, Mech Syst Struct & Dynam, Phoenix, AZ 85034 USA. [Gurvich, Mark] United Technol Res Ctr, E Hartford, CT 06105 USA. [Urban, Michael] Sikorsky Aircraft Corp, Stratford, CT 06615 USA. [Bordick, Nathaniel] Army Aviat Appl Technol Directorate, Ft Eustis, VA 23604 USA. RP Ghoshal, A (reprint author), US Army, Res Lab, Vehicle Technol Directorate, Aberdeen Proving Ground, MD 21005 USA. EM anindya.ghoshal.civ@mail.mil FU [W911W6-08-2-0002] FX This research is partially funded by the Government under Agreement No. W911W6-08-2-0002. The US Government is authorized to reproduce and distribute reprints for Government purposes notwithstanding any copyright notation thereon. The views and conclusions contained in this document are those of the authors and should not be interpreted as representing the official policies, either expressed or implied, of the Aviation Applied Technology Directorate or the US Government. NR 42 TC 4 Z9 4 U1 5 U2 33 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1359-8368 EI 1879-1069 J9 COMPOS PART B-ENG JI Compos. Pt. B-Eng. PD MAR 15 PY 2015 VL 71 BP 52 EP 62 DI 10.1016/j.compositesb.2014.10.050 PG 11 WC Engineering, Multidisciplinary; Materials Science, Composites SC Engineering; Materials Science GA CA4QG UT WOS:000348889100007 ER PT J AU Bhoomiboonchoo, P Nisalak, A Chansatiporn, N Yoon, IK Kalayanarooj, S Thipayamongkolgul, M Endy, T Rothman, AL Green, S Srikiatkhachorn, A Buddhari, D Mammen, P Gibbons, RV AF Bhoomiboonchoo, Piraya Nisalak, Ananda Chansatiporn, Natkamol Yoon, In-Kyu Kalayanarooj, Siripen Thipayamongkolgul, Mathuros Endy, Timothy Rothman, Alan L. Green, Sharone Srikiatkhachorn, Anon Buddhari, Darunee Mammen, Mammen P. Gibbons, Robert V. TI Sequential dengue virus infections detected in active and passive surveillance programs in Thailand, 1994-2010 SO BMC PUBLIC HEALTH LA English DT Article ID PRIMARY-SCHOOL CHILDREN; HEMORRHAGIC-FEVER; SHOCK SYNDROME; TIME-INTERVAL; KAMPHAENG PHET; ETHNIC THAIS; DISEASE; PROTECTION; MOSQUITOS; RISK AB Background: The effect of prior dengue virus (DENV) exposure on subsequent heterologous infection can be beneficial or detrimental depending on many factors including timing of infection. We sought to evaluate this effect by examining a large database of DENV infections captured by both active and passive surveillance encompassing a wide clinical spectrum of disease. Methods: We evaluated datasets from 17 years of hospital-based passive surveillance and nine years of cohort studies, including clinical and subclinical DENV infections, to assess the outcomes of sequential heterologous infections. Chi square or Fisher's exact test was used to compare proportions of infection outcomes such as disease severity; ANOVA was used for continuous variables. Multivariate logistic regression was used to assess risk factors for infection outcomes. Results: Of 38,740 DENV infections, two or more infections were detected in 502 individuals; 14 had three infections. The mean ages at the time of the first and second detected infections were 7.6 +/- 3.0 and 11.2 +/- 3.0 years. The shortest time between sequential infections was 66 days. A longer time interval between sequential infections was associated with dengue hemorrhagic fever (DHF) in the second detected infection (OR 1.3, 95% CI 1.2-1.4). All possible sequential serotype pairs were observed among 201 subjects with DHF at the second detected infection, except DENV-4 followed by DENV-3. Among DENV infections detected in cohort subjects by active study surveillance and subsequent non-study hospital-based passive surveillance, hospitalization at the first detected infection increased the likelihood of hospitalization at the second detected infection. Conclusions: Increasing time between sequential DENV infections was associated with greater severity of the second detected infection, supporting the role of heterotypic immunity in both protection and enhancement. Hospitalization was positively associated between the first and second detected infections, suggesting a possible predisposition in some individuals to more severe dengue disease. C1 [Bhoomiboonchoo, Piraya; Nisalak, Ananda; Yoon, In-Kyu; Buddhari, Darunee] Armed Forces Res Inst Med Sci, Dept Virol, Bangkok 10400, Thailand. [Bhoomiboonchoo, Piraya; Chansatiporn, Natkamol; Thipayamongkolgul, Mathuros] Mahidol Univ, Fac Publ Hlth, Bangkok 10700, Thailand. [Kalayanarooj, Siripen] Queen Sirikit Natl Inst Child Hlth, Bangkok, Thailand. [Endy, Timothy] SUNY Syracuse, Dept Infect Dis, Syracuse, NY USA. [Rothman, Alan L.] Univ Rhode Isl, Providence, RI 02908 USA. [Green, Sharone; Srikiatkhachorn, Anon] Univ Massachusetts, Sch Med, Div Infect Dis & Immunol, Worcester, MA USA. [Mammen, Mammen P.] Vical Inc, San Diego, CA USA. [Gibbons, Robert V.] US Army, Inst Surg Res, San Antonio, TX USA. RP Bhoomiboonchoo, P (reprint author), Armed Forces Res Inst Med Sci, Dept Virol, Bangkok 10400, Thailand. EM augurivicky@gmail.com FU NIAID NIH HHS [P01 AI034533] NR 37 TC 11 Z9 11 U1 0 U2 9 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1471-2458 J9 BMC PUBLIC HEALTH JI BMC Public Health PD MAR 14 PY 2015 VL 15 AR 250 DI 10.1186/s12889-015-1590-z PG 10 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA CD8KY UT WOS:000351345000001 PM 25886528 ER PT J AU Xu, BL Gonella, G DeLacy, BG Dai, HL AF Xu, Bolei Gonella, Grazia DeLacy, Brendan G. Dai, Hai-Lung TI Adsorption of Anionic Thiols on Silver Nanoparticles SO JOURNAL OF PHYSICAL CHEMISTRY C LA English DT Article ID SELF-ASSEMBLED MONOLAYERS; OPTICAL 2ND-HARMONIC GENERATION; NONLINEAR LIGHT-SCATTERING; GOLD NANOPARTICLES; PARTICLE-SIZE; FREE-ENERGY; SURFACE; AU(111); NANOSTRUCTURES; ALKANETHIOLS AB The adsorption of negatively charged 3-mercaptopropanesulfonate (MPS) on the surface of citrate stabilized Ag thartopartides in water is investigated using colloidal particle Surface sensitive techniques. The adsorption of this negatively charged thiol appears to be qualitatively different from that of neutral thiols and highlights the importance of repulsive interactions of electrostatic and aerie origins pertaining to charged thicilS. For the charged MPS thiol, the adsorption process occurs in two phases. At low Surface coverage, the intermolecular repialsiolleis negligible and the adsorption is dominated by the formation of the S-Ag bond, MPS molecules need to overcome an activation energy barrier (7.5 +/- 0.9) kcal/mol with an associated free energy change Delta G(ads) = -(14.3 +/- 0.3) kcal/mol and behave similar to neutrkthiols. On the other hand, at high surface coverage Where the repulsive interactions among MPS molecules cannot be neglected, the adsorption is Characterized by a higher E-a = (12.4 0.5) kcal/mol and lower Delta G(ads) = -(7.4 +/- 0.1) kcal/mol. C1 [Xu, Bolei; Gonella, Grazia; Dai, Hai-Lung] Temple Univ, Dept Chem, Philadelphia, PA 19122 USA. [DeLacy, Brendan G.] US Army Edgewood Chem Biol Ctr, Res & Technol Directorate, Aberdeen Proving Ground, MD 21010 USA. RP Gonella, G (reprint author), Max Planck Inst Polymer Res, Ackermannweg 10, D-55128 Mainz, Germany. EM gonella@mpip-mainz.mpg.de RI Gonella, Grazia/K-3464-2012; Xu, Bolei/O-8493-2016 OI Xu, Bolei/0000-0001-5352-0139 FU STC through Edgewood Chemical Biological Center Research and Technology Directorate [13-01-9030-003, W911SR-10-D0010]; AFOSR [FA-9550-08-1-0092] FX This work was supported by the STC 13-01-9030-003 grant (through the Edgewood Chemical Biological Center Research and Technology Directorate Task Order W911SR-10-D0010). We acknowledge AFOSR for providing the equipment for the nonlinear light scattering experiment through grant FA-9550-08-1-0092. We thank Ms. Samantha L. Shumlas for assistance with the TEM, Prof. S. L. Wunder for the use of the DLS instrument, Prof. B. Wayland for the use of the spectrophotometer, and Prof. E. Borguet for useful discussions. NR 50 TC 3 Z9 3 U1 2 U2 25 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1932-7447 J9 J PHYS CHEM C JI J. Phys. Chem. C PD MAR 12 PY 2015 VL 119 IS 10 BP 5454 EP 5461 DI 10.1021/jp511997w PG 8 WC Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary SC Chemistry; Science & Technology - Other Topics; Materials Science GA CD6HB UT WOS:000351189100024 ER PT J AU Mait, JN Mahalanobis, A Neifeld, MA Athale, RA AF Mait, Joseph N. Mahalanobis, Abhijit Neifeld, Mark A. Athale, Ravindra A. TI Compressive Sensing Focus Issue: introduction SO APPLIED OPTICS LA English DT Editorial Material C1 [Mait, Joseph N.] US Army Res Lab, RDRL D, Adelphi, MD 20783 USA. [Mahalanobis, Abhijit] Lockheed Martin Corp, Orlando, FL 32819 USA. [Neifeld, Mark A.] Univ Arizona, Dept Elect & Comp Engn, Tucson, AZ 85721 USA. [Athale, Ravindra A.] Off Naval Res, Arlington, VA 22203 USA. RP Mait, JN (reprint author), US Army Res Lab, RDRL D, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM joseph.n.mait2.civ@mail.mil NR 2 TC 1 Z9 1 U1 2 U2 8 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1559-128X EI 2155-3165 J9 APPL OPTICS JI Appl. Optics PD MAR 10 PY 2015 VL 54 IS 8 BP CS1 EP CS3 DI 10.1364/AO.54.000CS1 PG 3 WC Optics SC Optics GA CC9AE UT WOS:000350658900004 PM 25968401 ER PT J AU Glaros, TG Blancett, CD Bell, TM Natesan, M Ulrich, RG AF Glaros, Trevor G. Blancett, Candace D. Bell, Todd M. Natesan, Mohan Ulrich, Robert G. TI Serum biomarkers of Burkholderia mallei infection elucidated by proteomic imaging of skin and lung abscesses SO CLINICAL PROTEOMICS LA English DT Article DE Imaging mass spectrometry; Biomarker; Burkholderia mallei; Burkholderia pseudomallei; Laser capture microdissection; LC-MS/MS; Protein microarray; Glanders; Melioidosis; GroEL; Calprotectin; Formalin-fixed paraffin embedded tissue; FFPE ID FORMALDEHYDE-INDUCED MODIFICATIONS; HEAT-SHOCK PROTEINS; MASS-SPECTROMETRY; GLANDERS; GROEL; IDENTIFICATION; PEPTIDES; PSEUDOMALLEI; VACCINATION; SAMPLES AB Background: The bacterium Burkholderia mallei is the etiological agent of glanders, a highly contagious, often fatal zoonotic infectious disease that is also a biodefense concern. Clinical laboratory assays that analyze blood or other biological fluids are the highest priority because these specimens can be collected with minimal risk to the patient. However, progress in developing sensitive assays for monitoring B. mallei infection is hampered by a shortage of useful biomarkers. Results: Reasoning that there should be a strong correlation between the proteomes of infected tissues and circulating serum, we employed imaging mass spectrometry (IMS) of thin-sectioned tissues from Chlorocebus aethiops (African green) monkeys infected with B. mallei to localize host and pathogen proteins that were associated with abscesses. Using laser-capture microdissection of specific regions identified by IMS and histology within the tissue sections, a more extensive proteomic analysis was performed by a technique that combined the physical separation capabilities of liquid chromatography (LC) with the sensitive mass analysis capabilities of mass spectrometry (LC-MS/MS). By examining standard formalin-fixed, paraffin-embedded tissue sections, this strategy resulted in the identification of several proteins that were associated with lung and skin abscesses, including the host protein calprotectin and the pathogen protein GroEL. Elevated levels of calprotectin detected by ELISA and antibody responses to GroEL, measured by a microarray of the bacterial proteome, were subsequently detected in the sera of C. aethiops, Macaca mulatta, and Macaca fascicularis primates infected with B. mallei. Conclusions: Our results demonstrate that a combination of multidimensional MS analysis of traditional histology specimens with high-content protein microarrays can be used to discover lead pairs of host-pathogen biomarkers of infection that are identifiable in biological fluids. C1 [Glaros, Trevor G.; Natesan, Mohan; Ulrich, Robert G.] USAMRIID, Mol & Translat Sci, Frederick, MD 21702 USA. [Blancett, Candace D.; Bell, Todd M.] US Army, Pathol, Med Res Inst Infect Dis, Frederick, MD 21702 USA. RP Ulrich, RG (reprint author), USAMRIID, Mol & Translat Sci, Frederick, MD 21702 USA. EM rulrich@bhsai.org FU Defense Threat Reduction Agency [CB3498] FX This project was supported in part by contract CB3498 (RGU) from the Defense Threat Reduction Agency and by appointment of TGG to the Research Participation Program for the U.S. Army Medical Research and Materiel Command, administered through an agreement with the U.S. Department of Energy. NR 32 TC 2 Z9 2 U1 4 U2 5 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1542-6416 EI 1559-0275 J9 CLIN PROTEOM JI Clin. Proteom. PD MAR 10 PY 2015 VL 12 AR 7 DI 10.1186/s12014-015-9079-4 PG 14 WC Biochemical Research Methods SC Biochemistry & Molecular Biology GA DF2XB UT WOS:000371206600001 PM 26034464 ER PT J AU Cahill, JP Okusaga, O Zhou, WM Menyuk, CR Carter, GM AF Cahill, James P. Okusaga, Olukayode Zhou, Weimin Menyuk, Curtis R. Carter, Gary M. TI Superlinear growth of Rayleigh scattering-induced intensity noise in single-mode fibers SO OPTICS EXPRESS LA English DT Article ID OPTICAL-FIBERS; BACKSCATTERING; AMPLIFIERS AB Rayleigh scattering generates intensity noise close to an optical carrier that propagates in a single-mode optical fiber. This noise degrades the performance of optoelectronic oscillators and RF-photonic links. When using a broad linewidth laser, we previously found that the intensity noise power scales linearly with optical power and fiber length, which is consistent with guided entropy mode Rayleigh scattering (GEMRS), a third order nonlinear scattering process, in the spontaneous limit. In this work, we show that this behavior changes significantly with the use of a narrow linewidth laser. Using a narrow linewidth laser, we measured the bandwidth of the intensity noise plateau to be 10 kHz. We found that the scattered noise power scales superlinearly with fiber length up to lengths of 10 km in the frequency range of 500 Hz to 10 kHz, while it scales linearly in the frequency range of 10 Hz to 100 Hz. These results suggest that the Rayleigh-scattering-induced intensity noise cannot be explained by third-order nonlinear scattering in the spontaneous limit, as previously hypothesized. (C) 2015 Optical Society of America C1 [Cahill, James P.; Okusaga, Olukayode; Zhou, Weimin] US Army, Res Lab, Adelphi, MD 20783 USA. [Cahill, James P.; Menyuk, Curtis R.; Carter, Gary M.] Univ Maryland, Dept Comp Sci & Elect Engn, Baltimore, MD 21250 USA. RP Cahill, JP (reprint author), US Army, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM james.p.cahill.ctr@us.army.mil NR 18 TC 7 Z9 7 U1 1 U2 7 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1094-4087 J9 OPT EXPRESS JI Opt. Express PD MAR 9 PY 2015 VL 23 IS 5 BP 6400 EP 6407 DI 10.1364/OE.23.006400 PG 8 WC Optics SC Optics GA CD2BL UT WOS:000350878500089 PM 25836860 ER PT J AU Stack, DT Lee, PJ Quraishi, Q AF Stack, Daniel T. Lee, Patricia J. Quraishi, Qudsia TI Simple and efficient absorption filter for single photons from a cold atom quantum memory SO OPTICS EXPRESS LA English DT Article ID COMMUNICATION; ENSEMBLES; ENTANGLEMENT; VAPOR; LIGHT AB The ability to filter unwanted light signals is critical to the operation of quantum memories based on neutral atom ensembles. Here we demonstrate an efficient frequency filter which uses a vapor cell filled with Rb-85 and a buffer gas to attenuate both residual laser light and noise photons by nearly two orders of magnitude with little loss to the single photons associated with our cold Rb-87 quantum memory. This simple, passive filter provides an additional 18 dB attenuation of our pump laser and erroneous spontaneous emissions for every 1 dB loss of the single photon signal. We show that the addition of a frequency filter increases the non-classical correlations and the retrieval efficiency of our quantum memory by approximate to 35%. (C) 2015 Optical Society of America C1 [Stack, Daniel T.; Lee, Patricia J.; Quraishi, Qudsia] US Army, Res Lab, Quantum Sci Grp, Adelphi, MD 20783 USA. RP Quraishi, Q (reprint author), US Army, Res Lab, Quantum Sci Grp, Adelphi, MD 20783 USA. EM qudsia.quraishi.civ@mail.mil FU Army Research Laboratory FX We would like thank N. Solmeyer, D. Matsukevich, and A. Gorshkov for discussions on the quantum memory and P. Kunz for discussions on the vapor cell. DS is an Oak Ridge Associated Universities (ORAU) postdoctoral fellow. Research was sponsored by the Army Research Laboratory. The views and conclusions contained in this document are those of the Authors and should not be interpreted as representing the official policies, either expressed or implied, of the Army Research Laboratory or the U.S. Government. The U.S. Government is authorized to reproduce and distribute reprints for Government purposes notwithstanding any copyright notation herein. NR 28 TC 3 Z9 3 U1 2 U2 16 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1094-4087 J9 OPT EXPRESS JI Opt. Express PD MAR 9 PY 2015 VL 23 IS 5 BP 6822 EP 6832 DI 10.1364/OE.23.006822 PG 11 WC Optics SC Optics GA CD2BL UT WOS:000350878500130 PM 25836902 ER PT J AU Jennings, NA AF Jennings, Nathan A. TI Texas Ranger Auxiliaries: Double-Edged Sword of the Campaign for Northern Mexico, 1846-1848 SO SMALL WARS AND INSURGENCIES LA English DT Article DE counterguerrilla warfare; Mexican War; Texas Rangers; Texas Devils; Monterrey; Maj. Gen. Zachary Taylor; Federacion Hill AB This essay explores how federalized Texas Rangers, in the form of scout companies and larger mounted rifle regiments, provided controversial, and ultimately cost-effective, versatility to the US Army during its campaign in Northern Mexico between 1846 and 1848. It argues that their contributions centered on three tactical tasks that enhanced the invading army's maneuvers: reconnaissance, direct assault, and counterguerrilla patrolling. Each of these actions reflected a distinctive skill-set at which the auxiliaries excelled, marking them as exceptionally multifunctional assets. The Texans' augmentation coincided with, and was necessitated by, the evolving stages of the war in Northern Mexico, beginning with the American army's initial invasion, then transitioning to the assault on Monterrey, and finally ending with a troubled occupation where the rangers' brutality both enabled and undermined American pacification efforts. C1 US Mil Acad, West Point, NY 10996 USA. RP Jennings, NA (reprint author), US Mil Acad, West Point, NY 10996 USA. EM nathan.jennings@us.army.mil NR 49 TC 0 Z9 0 U1 0 U2 1 PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND SN 0959-2318 EI 1743-9558 J9 SMALL WAR INSUR JI Small War Insur. PD MAR 4 PY 2015 VL 26 IS 2 BP 313 EP 334 DI 10.1080/09592318.2015.1007560 PG 22 WC International Relations SC International Relations GA CI1CI UT WOS:000354477900006 ER PT J AU Sivasuthan, S Karthik, VU Rahunanthan, A Jayakumar, P Thyagarajan, RS Udpa, L Hoole, SRH AF Sivasuthan, S. Karthik, V. U. Rahunanthan, A. Jayakumar, P. Thyagarajan, R. S. Udpa, Lalita Hoole, S. R. H. TI A Script-Based, Parameterized Finite Element Mesh for Design and NDE on a GPU SO IETE TECHNICAL REVIEW LA English DT Article DE Optimization; NDE; Finite elements; GPU ID GRAPHICS PROCESSING UNITS; ELECTROMAGNETIC DEVICES; OPTIMIZATION; IMPLEMENTATION; COMPUTATION; ALGORITHMS AB Finite element mesh generators exist in the public domain, a few even based on a parametric device description. The typical mesh generator requires some man-machine interaction to define the points and boundary conditions, and does not work for non-stop optimization iterations for which we need a mesh dynamically evolving through the iterations with optimization variables as changing parameters. Such mesh generators as do exist are rare, commercial, and not easily available to researchers except at great cost and never with the code to modify them to suit individual needs. We take a regular open source mesh generator and write a script-based interface as open source to run non-stop for optimization. We then use it to create a non-destructive evaluation system for army ground vehicles' defect characterization and use it equally for machine design. A simple scheme of averaging neighbour heights gives us a smooth geometry without having to use Bezier curves. The mesh runs on the central processing unit but finite element optimization is on the graphics processing unit for speed and practicable testing times. C1 [Sivasuthan, S.; Karthik, V. U.; Udpa, Lalita; Hoole, S. R. H.] Michigan State Univ, Dept Elect & Comp Engn, E Lansing, MI 48823 USA. [Rahunanthan, A.] Edinboro Univ, Dept Math & Comp Sci, Edinboro, PA 16444 USA. [Jayakumar, P.; Thyagarajan, R. S.] US Army Tank Automot Res Dev & Engn Ctr, Warren, MI 48397 USA. RP Sivasuthan, S (reprint author), Michigan State Univ, Dept Elect & Comp Engn, E Lansing, MI 48823 USA. EM sivasuth@msu.edu; uthayaku@msu.edu; rahunanthana@gmail.com; paramsothy.jayakumar.civ@mail.mil; ravi.s.thyagarajan.civ@mail.mil; udpal@msu.edu; srhhoole@gmail.com FU US Army's TARDEC [W911NF-11-D-0001] FX Funded in part by the US Army's TARDEC [contract number W911NF-11-D-0001]. NR 41 TC 3 Z9 3 U1 1 U2 3 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 0256-4602 EI 0974-5971 J9 IETE TECH REV JI IETE Tech. Rev. PD MAR 4 PY 2015 VL 32 IS 2 BP 94 EP 103 DI 10.1080/02564602.2014.983192 PG 10 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA CE5AS UT WOS:000351842700003 ER PT J AU Gao, T Han, FD Zhu, YJ Suo, LM Luo, C Xu, K Wang, CS AF Gao, Tao Han, Fudong Zhu, Yujie Suo, Liumin Luo, Chao Xu, Kang Wang, Chunsheng TI Hybrid Mg2+/Li+ Battery with Long Cycle Life and High Rate Capability SO ADVANCED ENERGY MATERIALS LA English DT Article DE daniel cells; dendrite-free magnesium anodes; electrolyte-compatible cathodes; high reversibility; mixed-ion electrolytes ID RECHARGEABLE MAGNESIUM BATTERIES; ELECTROLYTE-SOLUTIONS; CURRENT COLLECTORS; CATHODE MATERIALS; MG BATTERIES; DEPOSITION; CHALLENGE; STABILITY; CHEMISTRY; PROGRESS C1 [Gao, Tao; Han, Fudong; Zhu, Yujie; Suo, Liumin; Luo, Chao; Wang, Chunsheng] Univ Maryland, Dept Chem & Biomol Engn, College Pk, MD 20740 USA. [Xu, Kang] US Army Res Lab, Electrochem Branch, Power & Energy Div, Sensor & Electron Devices Directorate, Adelphi, MD 20783 USA. RP Wang, CS (reprint author), Univ Maryland, Dept Chem & Biomol Engn, College Pk, MD 20740 USA. EM cswang@umd.edu RI Wang, Chunsheng/H-5767-2011 OI Wang, Chunsheng/0000-0002-8626-6381 FU DoE ARPA-E [DEAR0000389]; Maryland NanoCenter, NispLab; NSF as a MRSEC Shared Experimental Facility FX This work was supported by DoE ARPA-E (DEAR0000389). The authors acknowledge the support of the Maryland NanoCenter and its NispLab. The NispLab is supported in part by the NSF as a MRSEC Shared Experimental Facility. NR 34 TC 17 Z9 17 U1 19 U2 161 PU WILEY-V C H VERLAG GMBH PI WEINHEIM PA BOSCHSTRASSE 12, D-69469 WEINHEIM, GERMANY SN 1614-6832 EI 1614-6840 J9 ADV ENERGY MATER JI Adv. Energy Mater. PD MAR 4 PY 2015 VL 5 IS 5 AR 1401507 DI 10.1002/aenm.201401507 PG 5 WC Chemistry, Physical; Energy & Fuels; Materials Science, Multidisciplinary; Physics, Applied; Physics, Condensed Matter SC Chemistry; Energy & Fuels; Materials Science; Physics GA CD0IP UT WOS:000350754800011 ER PT J AU Hawkins, AD Thornton, C Kennedy, AJ Bu, KX Cizdziel, J Jones, BW Steevens, JA Willett, KL AF Hawkins, Adam D. Thornton, Cammi Kennedy, Alan J. Bu, Kaixuan Cizdziel, James Jones, Bradley W. Steevens, Jeffery A. Willett, Kristine L. TI Gill Histopathologies Following Exposure to Nanosilver or Silver Nitrate SO JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES LA English DT Article ID TROUT ONCORHYNCHUS-MYKISS; RAINBOW-TROUT; DISSOLVED SILVER; DAPHNIA-MAGNA; FISH GILL; TOXICITY; NANOPARTICLES; WATER; FRESH; ZEBRAFISH AB Fish gill is the site for many crucial physiological functions. It is among the first sites of xenobiotic exposure, and gill histopathological alterations may be detected soon after toxicant exposure. Silver (Ag) is one of the most toxic metals to aquatic organisms mainly due to its ability to disrupt ionic regulation. The goal of this study was to determine the effect of ionic and nanoscale Ag on fathead minnow gills by examining gill histology and Na+/K+-ATPase immunoreactivity. Fathead minnows were exposed to two measured concentrations of silver nitrate (AgNO3: 1.3 or 3.7 mu g/L as Ag+), citrate silver nanoparticles (citrate-AgNP: 15 or 39 mu g/L), and polyvinylpyrrolidone-AgNP (PVP-AgNP) (AgNP: 11 or 50 mu g/L). Circulatory disturbances were the most prevalent gill alterations detected and were significantly increased in all Ag treatment groups compared to control. AgNO3 (1.3 mu g/L) was the only treatment that significantly elevated the number of total mucous goblet cells present. In all other Ag treatments, the percent of degenerated goblet cells was significantly increased compared to control. When the sum of all histopathological abnormalities (weighted index) was calculated, all Ag groups displayed a significantly higher index, with citrate-AgNP having the highest toxicity (index of 10 +/- 0.32 versus 2.4 +/- 0.6 in controls). Gill Na+/K+-ATPase immunoreactivity was decreased by Ag. These results indicated that both AgNO3 and AgNP created similar disruptions in gill structure and ionic regulation, possibly due to the ionic Ag portion of each treatment. C1 [Hawkins, Adam D.; Thornton, Cammi; Willett, Kristine L.] Univ Mississippi, Sch Pharm, Dept BioMol Sci, University, MS 38677 USA. [Hawkins, Adam D.; Thornton, Cammi; Willett, Kristine L.] Univ Mississippi, Sch Pharm, Environm Toxicol Res Program, University, MS 38677 USA. [Kennedy, Alan J.; Steevens, Jeffery A.] US Army Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS USA. [Bu, Kaixuan; Cizdziel, James] Univ Mississippi, Dept Chem, University, MS 38677 USA. [Jones, Bradley W.] Univ Mississippi, Dept Biol, University, MS 38677 USA. RP Willett, KL (reprint author), Univ Mississippi, Sch Pharm, Dept BioMol Sci, 305 Faser Hall,Box 1848, University, MS 38677 USA. EM kwillett@olemiss.edu FU U.S. Army Environmental Quality and Technology Program FX We thank Catherine Freeland, Frank Booc, and Khalid Alharthy for assistance with water changes, feedings, and dissections. Dr. Alvin C. Camus (University of Georgia) provided suggestions related to gill histopathology. Ashley Harmon (U.S. Army ERDC) performed measurements of particles in TEM images. This research was supported by the U.S. Army Environmental Quality and Technology Program (Dr. Elizabeth Ferguson, Technical Director). Permission was granted by the Chief of Engineers to publish this information. NR 55 TC 2 Z9 2 U1 0 U2 22 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA SN 1528-7394 EI 1087-2620 J9 J TOXICOL ENV HEAL A JI J. Toxicol. Env. Health Part A PD MAR 4 PY 2015 VL 78 IS 5 BP 301 EP 315 DI 10.1080/15287394.2014.971386 PG 15 WC Environmental Sciences; Public, Environmental & Occupational Health; Toxicology SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health; Toxicology GA CC4CN UT WOS:000350298500002 PM 25734626 ER PT J AU Patil, RR Turgman-Cohen, S Srogl, J Kiserow, D Genzer, J AF Patil, Rohan R. Turgman-Cohen, Salomon Srogl, Jiri Kiserow, Douglas Genzer, Jan TI On-Demand Degrafting and the Study of Molecular Weight and Grafting Density of Poly(methyl methacrylate) Brushes on Flat Silica Substrates SO LANGMUIR LA English DT Article ID TRANSFER RADICAL POLYMERIZATION; WELL-DEFINED POLYMER; COMPUTER-SIMULATION; SURFACE; ATRP; INITIATOR; FRICTION; ADSORPTION; MONOLAYERS; THICKNESS AB We report on degrafting of surface-anchored poly(methyl methacrylate) (PMMA) brushes from flat silica-based substrates using tetrabutylammonium fluoride (TBAF) and determining their molecular weight distribution (MWD) using size exclusion chromatography (SEC). The grafted PMMA layer was synthesized using surface-initiated atom transfer radical polymerization (SI-ATRP) of MMA for polymerization times ranging from 6 to 24 h. X-ray photoelectron spectroscopy, ellipsometry, and time-of-flight secondary ion mass spectrometry were employed in tandem to characterize the degrafting process. The SEC eluograms were fit to various polymer distributions, namely Zimm-Schulz, ATRP in continuous stirred tank reactor, Wesslau, Schulz-Flory, and Smith et al. The ATRP model gives the best fit to the experimental data. The dry PMMA brush thickness and the number-average molecular weight (obtained from the MWD) suggest that the grafting density of the PMMA grafts is independent of polymerization time, indicating well-controlled/living growth of MMA. The observed polydispersity index (PDI) was higher than that generally observed in bulk grown polymers under similar conditions, indicating an effect due to chain confinement and crowding. We detect small but noticeable dependence of the polymer brush grafting density on the inhibitor/catalyst ratio. Higher inhibitor/catalyst ratio offers better control with lower early terminations, which results in a small increase in the apparent grafting density of the chains. C1 [Patil, Rohan R.; Srogl, Jiri; Kiserow, Douglas; Genzer, Jan] N Carolina State Univ, Dept Chem & Biomol Engn, Raleigh, NC 27695 USA. [Turgman-Cohen, Salomon] Kettering Univ, Dept Chem Engn, Flint, MI 48504 USA. [Kiserow, Douglas] US Army, Res Off, Res Triangle Pk, NC 27709 USA. RP Genzer, J (reprint author), N Carolina State Univ, Dept Chem & Biomol Engn, Raleigh, NC 27695 USA. EM jan_genzer@ncsu.edu FU National Science Foundation [DMR-0906572]; Army Research Office under their Staff Research Program [W911NF-04-D-0003-0016] FX The work was supported by the National Science Foundation (Grant DMR-0906572) and the Army Research Office under their Staff Research Program (Grant no. W911NF-04-D-0003-0016). NR 53 TC 16 Z9 16 U1 11 U2 83 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0743-7463 J9 LANGMUIR JI Langmuir PD MAR 3 PY 2015 VL 31 IS 8 BP 2372 EP 2381 DI 10.1021/la5044766 PG 10 WC Chemistry, Multidisciplinary; Chemistry, Physical; Materials Science, Multidisciplinary SC Chemistry; Materials Science GA CC8II UT WOS:000350611300016 PM 25654273 ER PT J AU Flinker, A Korzeniewska, A Shestyuk, AY Franaszczuk, PJ Dronkers, NF Knight, RT Crone, NE AF Flinker, Adeen Korzeniewska, Anna Shestyuk, Avgusta Y. Franaszczuk, Piotr J. Dronkers, Nina F. Knight, Robert T. Crone, Nathan E. TI Redefining the role of Broca's area in speech SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA LA English DT Article DE Broca; speech; ECoG ID WORD PRODUCTION COMPONENTS; EVENT-RELATED CAUSALITY; TEMPORAL SIGNATURES; AUDITORY-CORTEX; GAMMA ACTIVITY; LANGUAGE; BRAIN; INFORMATION; DYNAMICS; APHASIA AB For over a century neuroscientists have debated the dynamics by which human cortical language networks allow words to be spoken. Although it is widely accepted that Broca's area in the left inferior frontal gyrus plays an important role in this process, it was not possible, until recently, to detail the timing of its recruitment relative to other language areas, nor how it interacts with these areas during word production. Using direct cortical surface recordings in neurosurgical patients, we studied the evolution of activity in cortical neuronal populations, as well as the Granger causal interactions between them. We found that, during the cued production of words, a temporal cascade of neural activity proceeds from sensory representations of words in temporal cortex to their corresponding articulatory gestures in motor cortex. Broca's area mediates this cascade through reciprocal interactions with temporal and frontal motor regions. Contrary to classic notions of the role of Broca's area in speech, while motor cortex is activated during spoken responses, Broca's area is surprisingly silent. Moreover, when novel strings of articulatory gestures must be produced in response to non-word stimuli, neural activity is enhanced in Broca's area, but not in motor cortex. These unique data provide evidence that Broca's area coordinates the transformation of information across large-scale cortical networks involved in spoken word production. In this role, Broca's area formulates an appropriate articulatory code to be implemented by motor cortex. C1 [Flinker, Adeen; Shestyuk, Avgusta Y.; Knight, Robert T.] Univ Calif Berkeley, Helen Wills Neurosci Inst, Berkeley, CA 94720 USA. [Korzeniewska, Anna; Franaszczuk, Piotr J.; Crone, Nathan E.] Johns Hopkins Univ, Sch Med, Dept Neurol Cognit Neurophysiol, Baltimore, MD 21287 USA. [Korzeniewska, Anna; Franaszczuk, Piotr J.; Crone, Nathan E.] Johns Hopkins Univ, Sch Med, Brain Machine Interface Lab, Baltimore, MD 21287 USA. [Franaszczuk, Piotr J.] US Army, Res Lab, Human Res & Engn Directorate, Aberdeen Proving Ground, MD 21005 USA. [Dronkers, Nina F.] VA Northern Calif Hlth Care Syst, Ctr Aphasia & Related Disorders, Martinez, CA 94553 USA. [Dronkers, Nina F.] Univ Calif Davis, Dept Neurol, Davis, CA 95817 USA. [Knight, Robert T.] Univ Calif Berkeley, Dept Psychol, Berkeley, CA 94720 USA. RP Flinker, A (reprint author), Univ Calif Berkeley, Helen Wills Neurosci Inst, Berkeley, CA 94720 USA. EM adeen.f@gmail.com RI Franaszczuk, Piotr/B-6532-2008 OI Franaszczuk, Piotr/0000-0002-5166-4224 FU National Institute of Neurological Disorders and Stroke (NINDS) [NS40596]; Nielsen Corporation; NIH [2R37NS21135]; NINDS [F31NS065656]; National Institute of Mental Health [F32MH075317]; VA CSR&D Research Career Scientist Award FX This work was supported by the National Institute of Neurological Disorders and Stroke (NINDS) Grant NS40596 (to N.E.C.), the Nielsen Corporation and the NIH Grant 2R37NS21135 (to R.T.K.), NINDS Grant F31NS065656 (to A. F.), a VA CSR&D Research Career Scientist Award (to N.F.D), and the National Institute of Mental Health Grant F32MH075317 (to A.Y.S). NR 37 TC 20 Z9 20 U1 5 U2 41 PU NATL ACAD SCIENCES PI WASHINGTON PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA SN 0027-8424 J9 P NATL ACAD SCI USA JI Proc. Natl. Acad. Sci. U. S. A. PD MAR 3 PY 2015 VL 112 IS 9 BP 2871 EP 2875 DI 10.1073/pnas.1414491112 PG 5 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA CC3DK UT WOS:000350224900068 PM 25730850 ER PT J AU Voronin, Y Zinszner, H Karg, C Brooks, K Coombs, R Hural, J Holt, R Fast, P Allen, M Busch, M Fruth, U Golding, H Khurana, S Mulenga, J Peel, S Schito, M Voronin, Y Barnabas, N Bentsen, C Graham, B Gray, G Levin, A McCluskey, M O'Connell, R Snow, B Ware, M AF Voronin, Yegor Zinszner, Helene Karg, Carissa Brooks, Katie Coombs, Robert Hural, John Holt, Renee Fast, Pat Allen, Mary Busch, Michael Fruth, Ulrich Golding, Hana Khurana, Surender Mulenga, Joseph Peel, Sheila Schito, Marco Voronin, Yegor Barnabas, Nomampondo Bentsen, Christopher Graham, Barney Gray, Glenda Levin, Andrew McCluskey, Margaret O'Connell, Robert Snow, Bill Ware, Mark CA VISR Working Grp Global HIV Vaccin TI HIV vaccine-induced sero-reactivity: A challenge for trial participants, researchers, and physicians SO VACCINE LA English DT Review DE HIV; Vaccine; Vaccine-induced sero-positivity; Vaccine-induced sero-reactivity; VISR; VISP ID DIFFERENTIAL-DIAGNOSIS; GENERATED ANTIBODIES; SEROPOSITIVITY; INFECTIONS; RECIPIENTS; ASSAY; FACE AB Antibody-inducing vaccines are a major focus in the preventive HIV vaccine field. Because the most common tests for HIV infection rely on detecting antibodies to HIV, they may also detect antibodies induced by a candidate HIV vaccine. The detection of vaccine-induced antibodies to HIV by serological tests is most commonly referred to as vaccine-induced sero-reactivity (VISR). VISR can be misinterpreted as a sign of HIV infection in a healthy study participant. In a participant who has developed vaccine-induced antibodies, accurate diagnosis of HIV infection (or lack thereof) may require specialized tests and algorithms (differential testing) that are usually not available in community settings. Organizations sponsoring clinical testing of preventive HIV vaccine candidates have an ethical obligation not only to inform healthy volunteers about the potential problems associated with participating in a clinical trial but also to help manage any resulting issues. This article explores the scope of VISR-related issues that become increasingly prevalent as the search for an effective HIV vaccine continues and will be paramount once a preventive vaccine is deployed. We also describe ways in which organizations conducting HIV vaccine trials have addressed these issues and outline areas where more work is needed. (C) 2014 The Authors. Published by Elsevier Ltd. C1 [Voronin, Yegor; Zinszner, Helene; Voronin, Yegor; Snow, Bill] Global HIV Vaccine Enterprise, New York, NY 10003 USA. [Karg, Carissa; Brooks, Katie; Hural, John; Holt, Renee] HIV Vaccine Trials Network, Seattle, WA USA. [Coombs, Robert] Univ Washington, Seattle, WA 98195 USA. [Fast, Pat] Int AIDS Vaccine Initiat, New York, NY USA. [Allen, Mary] NIAID, NIH, Bethesda, MD 20892 USA. [Busch, Michael] Blood Syst Res Inst, San Francisco, CA USA. [Fruth, Ulrich] WHO, CH-1211 Geneva, Switzerland. [Golding, Hana] Food & Drug Adm, Bethesda, MD USA. [Mulenga, Joseph] Zambia Natl Blood Transfus Serv, Lusaka, Zambia. [Peel, Sheila; O'Connell, Robert] Mil HIV Res Program, Silver Spring, MD USA. [Schito, Marco] Mil Med Inc, Div Henry M Jackson Fdn Adv, HJF DAIDS, Bethesda, MD USA. [Barnabas, Nomampondo; Gray, Glenda] Perinatal HIV Res Unit, Johannesburg, South Africa. [Bentsen, Christopher] Biorad Labs, Redmond, WA USA. [Graham, Barney] NIAID, Vaccine Res Ctr, NIH, Bethesda, MD 20892 USA. [Levin, Andrew] Immunetics Inc, Boston, MA USA. [McCluskey, Margaret] US Agcy Int Dev, Washington, DC 20523 USA. [O'Connell, Robert] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Ware, Mark] Clinton Hlth Access Initiat, Edinburgh, Midlothian, Scotland. RP Voronin, Y (reprint author), Global HIV Vaccine Enterprise, New York, NY 10003 USA. FU Federal funds from the National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Health and Human Services [HHSN272200800014C]; United States Agency for International Development (USAID) FX We would like to thank all participants of the March 2013 meeting "Vaccine-Induced Sero-Reactivity/Sero-Positivity", whose opinions greatly influenced the content of this article. For a complete list of participants and the meeting report, visit http://www.vaccineenterprise.org/content/timely-topic-VISP. This project has been funded in part with Federal funds from the National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Health and Human Services, under Contract No. HHSN272200800014C. IAVI's work is made possible by generous support from many donors, including the United States Agency for International Development (USAID). A full list of IAVI donors is available at www.iavi.org. NR 30 TC 2 Z9 2 U1 0 U2 6 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X EI 1873-2518 J9 VACCINE JI Vaccine PD MAR 3 PY 2015 VL 33 IS 10 BP 1243 EP 1249 DI 10.1016/j.vaccine.2014.10.040 PG 7 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA CC1EI UT WOS:000350083600005 ER PT J AU Jasuja, H Peterson, GW Decoste, JB Browe, MA Walton, KS AF Jasuja, Himanshu Peterson, Gregory W. Decoste, Jared B. Browe, Matthew A. Walton, Krista S. TI Evaluation of MOFs for air purification and air quality control applications: Ammonia removal from air SO CHEMICAL ENGINEERING SCIENCE LA English DT Article DE Ammonia; Adsorption; Metal-organic frameworks; Stability; Air purification; UiO-66 ID METAL-ORGANIC FRAMEWORKS; LIGAND FUNCTIONALIZATION; ADSORPTION; STABILITY AB UiO-66 is a Zr-based MOF that is being highly investigated for a wide variety of small molecule gas separations since it possess unprecedented thermal, chemical, and mechanical stability. In this work, we have investigated the performance of various functionalized variations of UiO-66 (UiO-66-OH, UiO-66-(OH)(2), UiO-66-NO2, UiO-66-NH2, UiO-66-SO3H, and UiO-66-(COOH)(2)) towards ammonia removal from air. Functionalized UiO-66 analogs have been synthesized solvothermally and characterized using ammonia breakthrough measurements under dry and humid (80% RH) air conditions along with powder X-ray diffraction (PXRD) patterns and results from BET modeling of N-2 adsorption isotherms. Counter to chemical intuition, our study demonstrates that the ammonia capacities of UiO-66-SO3H and UiO-66-(COOH)(2) are lower than UiO-66-OH and UiO-66-NH2. This is due to significant reduction in the framework porosity (surface area and pore volume) upon functionalization with bulky functional groups such as -COOH and -SO3H. The -OH group is the least bulky functional group considered in the work and interacts favorably with ammonia. UiO-66-OH has a capacity of similar to 5.7 mmol/g for ammonia under dry conditions which is very close to the ammonia removal goal of 0.1 g/g MOF (or similar to 6 mmol/g). However, we observed a decrease in the ammonia capacities of functionalized UiO-66 variations under humid conditions due to competition between water and ammonia molecules for adsorption on the active sites. Overall, balancing the water adsorption behavior and high selectivity and high capacity for ammonia is crucial to developing new adsorbents for ammonia removal from air. (C) 2014 Elsevier Ltd. All rights reserved. C1 [Jasuja, Himanshu; Walton, Krista S.] Georgia Inst Technol, Sch Chem & Biomol Engn, Atlanta, GA 30332 USA. [Peterson, Gregory W.; Browe, Matthew A.] US Army, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. [Decoste, Jared B.] Leidos Inc, Gunpowder, MD 21010 USA. RP Walton, KS (reprint author), Georgia Inst Technol, Sch Chem & Biomol Engn, 311 Ferst Dr NW, Atlanta, GA 30332 USA. EM krista.walton@chbe.gatech.edu FU Army Research Office PECASE Award [W911NF-10-1-0079, W911NF-10-1-0076] FX This material is based upon work supported by Army Research Office PECASE Award W911NF-10-1-0079 and Contract W911NF-10-1-0076. NR 34 TC 23 Z9 23 U1 21 U2 172 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0009-2509 EI 1873-4405 J9 CHEM ENG SCI JI Chem. Eng. Sci. PD MAR 3 PY 2015 VL 124 BP 118 EP 124 DI 10.1016/j.ces.2014.08.050 PG 7 WC Engineering, Chemical SC Engineering GA CB2HF UT WOS:000349447000013 ER PT J AU Ivashchenko, VI Veprek, S Argon, AS Turchi, PEA Gorb, L Hill, F Leszczynski, J AF Ivashchenko, V. I. Veprek, S. Argon, A. S. Turchi, P. E. A. Gorb, L. Hill, F. Leszczynski, J. TI First-principles quantum molecular calculations of structural and mechanical properties of TiN/SiNx heterostructures, and the achievable hardness of the nc-TiN/SiNx nanocomposites SO THIN SOLID FILMS LA English DT Article DE Superhard nanocomposites; TiN/SiNx heterostructures; First-principles molecular dynamics; Thermal stability; Stress-strain relations; Ideal strength; Achievable hardness ID STRONGEST SIZE; COATINGS; ORIGIN; NC-TIN/A-SI3N4; MICROSTRUCTURE; NANOSTRUCTURE; DEFORMATION; ENHANCEMENT; IMPURITIES; NITRIDE AB TiN/SiNx heterostructures with one monolayer of the interfacial SiNx have been investigated in the framework of first-principles molecular dynamics calculations in the temperature range of 0 to 1400 K with subsequent static relaxation. The atomic configurations, thermal stability and stress-strain relations have been calculated. Among the heterostructures studied, only the TiN(111)/SiN/TiN(111) and TiN(111)/Si2N3/TiN(111) ones are thermally stable. Upon tensile load, decohesion occurs between the Ti-N bonds adjacent to the SiNx interfacial layer for TiN(001)/SiN/TiN(001) and TiN(111)/Si2N3/TiN(111) heterostructures, and inside the TiN slab for TiN(001)/Si3N4/TiN(001) and TiN(110)/SiN/TiN(110) ones. Upon shear, failure occurs in TiN near the interfaces in all the heterostructures, except for the TiN(001)/Si3N4/TiN(001) one, for which the plastic flow occurs inside the TiN slab. Based on these results we estimate the maximum achievable hardness of nc-TiN/Si3N4 nanocomposites free of impurities to be about 170 GPa. (C) 2015 Elsevier B.V. All rights reserved. C1 [Ivashchenko, V. I.] Natl Acad Sci Ukraine, Inst Problems Mat Sci, UA-03142 Kiev, Ukraine. [Veprek, S.] Tech Univ Munich, Dept Chem, D-85747 Garching, Germany. [Argon, A. S.] MIT, Dept Mech Engn, Cambridge, MA 02139 USA. [Turchi, P. E. A.] Lawrence Livermore Natl Lab, L 352, Livermore, CA 94551 USA. [Gorb, L.] Badger Tech Serv LLC, Vicksburg, MS 39180 USA. [Gorb, L.; Hill, F.] US Army, Erdc, Vicksburg, MS 39180 USA. [Leszczynski, J.] Jackson State Univ, Interdisciplinary Ctr Nanotox, Dept Chem & Biochem, Jackson, MS 39217 USA. RP Veprek, S (reprint author), Tech Univ Munich, Dept Chem, Lichtenbergstr 4, D-85747 Garching, Germany. EM ivash@ipms.kiev.ua; stan.veprek@lrz.tum.de RI Veprek, Stan/C-1248-2008 OI Veprek, Stan/0000-0002-6016-3093 FU STCU [5964]; U.S. Department of Energy by the Lawrence Livermore National Laboratory, Office of Science [DE-AC52-07NA27344]; Summer Institute at Jackson State University; company SHM; Mechanical Engineering Department at MIT FX This work was supported by the STCU contract, No. 5964. The work of P.T. was performed under the auspices of the U.S. Department of Energy by the Lawrence Livermore National Laboratory, Office of Science under contract No. DE-AC52-07NA27344. The authors are grateful to the directorate of the Summer Institute at Jackson State University for financial support and the opportunity to perform large-scale calculations. S.V. thanks the company SHM for financial support. A. S. A. acknowledges support from the Mechanical Engineering Department at MIT. Our thanks are due to Dr. Maritza Veprek-Heijman for valuable comments to the manuscript. NR 61 TC 5 Z9 6 U1 2 U2 30 PU ELSEVIER SCIENCE SA PI LAUSANNE PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND SN 0040-6090 J9 THIN SOLID FILMS JI Thin Solid Films PD MAR 2 PY 2015 VL 578 BP 83 EP 92 DI 10.1016/j.tsf.2015.02.013 PG 10 WC Materials Science, Multidisciplinary; Materials Science, Coatings & Films; Physics, Applied; Physics, Condensed Matter SC Materials Science; Physics GA CE2XX UT WOS:000351686500013 ER PT J AU Aurell, J Gullett, BK Tabor, D Williams, RK Mitchell, W Kemme, MR AF Aurell, Johanna Gullett, Brian K. Tabor, Dennis Williams, Ryan K. Mitchell, William Kemme, Michael R. TI Aerostat-based sampling of emissions from open burning and open detonation of military ordnance SO JOURNAL OF HAZARDOUS MATERIALS LA English DT Article DE Munitions; Emission factors; Open burning; Open detonation; Static firing ID PCDD/PCDF AB Emissions from open detonation (OD), open burning (OB), and static firing (SF) of obsolete military munitions were collected using an aerostat-lofted sampling instrument maneuvered into the plumes with remotely controlled tether winches. PM2.5, PM10, metals, volatile organic compounds (VOCs), energetics, and polyaromatic hydrocarbons (PAHs) were characterized from 121 trials of three different munitions (Composition B (hereafter, "Comp B"), V453, V548), 152 trials of five different propellants (M31A1E1, M26, SPCF, Arc 451, 452A), and 12 trials with static firing of ammonium perchlorate-containing Sparrow rocket motors. Sampling was conducted with operational charge sizes and under open area conditions to determine emission levels representative of actual disposal practices. The successful application of the tethered aerostat and sampling instruments demonstrated the ability to sample for and determine the first ever emission factors for static firing of rocket motors and buried and metal-cased OD, as well as the first measurements of PM2.5 for OB and for surface OD. Published by Elsevier B.V. C1 [Aurell, Johanna; Gullett, Brian K.; Tabor, Dennis] US EPA, Off Res & Dev, Natl Risk Management Res Lab, Res Triangle Pk, NC 27711 USA. [Williams, Ryan K.] US Dept Def, Joint Munit Command, Logist Integrat Directorate, Engn & Demil Technol Off,AMSJM LIB T, Tulsa, OK 74501 USA. [Mitchell, William] William Mitchell Bill Mitchell & Associates LLC, Durham, NC 27713 USA. [Kemme, Michael R.] US Army Engn Res & Dev Ctr, Construct Engn Res Lab, Attn CEERD CN E, Champaign, IL 61826 USA. RP Gullett, BK (reprint author), US EPA, Off Res & Dev, Natl Risk Management Res Lab, Res Triangle Pk, NC 27711 USA. EM aurell.johanna@epa.gov; gullett.brian@epa.gov; tabor.dennis@epa.gov; ryan.k.williams.civ@mail.mil; mitcbill@gmail.com; michael.r.kemme@usace.army.mil FU Strategic Environmental Research and Development Program; U.S. EPA; U.S. EPA/NRMRL FX This work was funded by the Strategic Environmental Research and Development Program and U.S. EPA. Technical advisors included Keith Clift, U.S. Army; Randy Cramer, Naval Ordnance Safety and Security Activity; Eric Erickson, Naval Air Warfare Center-Weapons Division, China Lake; Tony Livingston, Joint Munitions Command; GeorgeThompson, Chemical Compliance System, Inc. This research was performed while Johanna Aurell held a National Research Council Research Associateship Award at the U.S. EPA/NRMRL. The views expressed in this article are those of the authors and do not necessarily represent the views or policies of the U.S. EPA. NR 28 TC 1 Z9 1 U1 4 U2 22 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0304-3894 EI 1873-3336 J9 J HAZARD MATER JI J. Hazard. Mater. PD MAR 2 PY 2015 VL 284 BP 108 EP 120 DI 10.1016/j.jhazmat.2014.10.029 PG 13 WC Engineering, Environmental; Engineering, Civil; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA AY4YX UT WOS:000347581900014 PM 25463224 ER PT J AU Crum-Cianflone, NF Wang, X Weintrob, A Lalani, T Bavaro, M Okulicz, JF Mende, K Ellis, M Agan, BK AF Crum-Cianflone, Nancy F. Wang, Xun Weintrob, Amy Lalani, Tahaniyat Bavaro, Mary Okulicz, Jason F. Mende, Katrin Ellis, Michael Agan, Brian K. TI Specific Behaviors Predict Staphylococcus aureus Colonization and Skin and Soft Tissue Infections Among Human Immunodeficiency Virus-Infected Persons SO OPEN FORUM INFECTIOUS DISEASES LA English DT Article DE behaviors; colonization; HIV; human immunodeficiency virus; MRSA; risk factors; skin and soft tissue infections; Staphylococcus aureus ID METHICILLIN-RESISTANT; RISK-FACTORS; NASAL CARRIAGE; HIV-INFECTION; MRSA INFECTIONS; HEALTHY-ADULTS; DRUG-USERS; PREVALENCE; ASSOCIATION; OUTPATIENTS AB Background. Few data exist on the incidence and risk factors of Staphylococcus aureus colonization and skin and soft tissue infections (SSTIs) among patients infected with human immunodeficiency virus (HIV). Methods. Over a 2-year period, we prospectively evaluated adults infected with HIV for incident S aureus colonization at 5 body sites and SSTIs. Cox proportional hazard models using time-updated covariates were performed. Results. Three hundred twenty-two participants had a median age of 42 years (interquartile range, 32-49), an HIV duration of 9.4 years (2.7-17.4), and 58% were on highly active antiretroviral therapy (HAART). Overall, 102 patients (32%) became colonized with S aureus with an incidence rate of 20.6 (95% confidence interval [CI], 16.8-25.0) per 100 person-years [PYs]. Predictors of colonization in the final multivariable model included illicit drug use (hazard ratios [HR], 4.26; 95% CI, 1.33-13.69) and public gym use (HR 1.66, 95% CI, 1.04-2.66), whereas antibacterial soap use was protective (HR, 0.50; 95% CI, 0.32-0.78). In a separate model, perigenital colonization was associated with recent syphilis infection (HR, 4.63; 95% CI, 1.01-21.42). Fifteen percent of participants developed an SSTI (incidence rate of 9.4 cases [95% CI, 6.8-12.7] per 100 PYs). Risk factors for an SSTI included incident S aureus colonization (HR 2.52; 95% CI, 1.35-4.69), public shower use (HR, 2.59; 95% CI, 1.48-4.56), and hospitalization (HR 3.54; 95% CI, 1.67-7.53). The perigenital location for S aureus colonization was predictive of SSTIs. Human immunodeficiency virus-related factors (CD4 count, HIV RNA level, and HAART) were not associated with colonization or SSTIs. Conclusions. Specific behaviors, but not HIV-related factors, are predictors of colonization and SSTIs. Behavioral modifications may be the most important strategies in preventing S aureus colonization and SSTIs among persons infected with HIV. C1 [Crum-Cianflone, Nancy F.; Wang, Xun; Weintrob, Amy; Lalani, Tahaniyat; Bavaro, Mary; Okulicz, Jason F.; Mende, Katrin; Agan, Brian K.] Uniformed Serv Univ Hlth Sci, Infect Dis Clin Res Program, Bethesda, MD 20814 USA. [Ellis, Michael] Uniformed Serv Univ Hlth Sci, Dept Med, Bethesda, MD 20814 USA. [Crum-Cianflone, Nancy F.; Bavaro, Mary] Naval Med Ctr San Diego, Infect Dis Clin, San Diego, CA 92134 USA. [Wang, Xun; Mende, Katrin; Agan, Brian K.] Henry M Jackson Fdn Adv Mil Med, Bethesda, MD USA. [Weintrob, Amy] Walter Reed Army Med Ctr, Infect Dis Clin, Washington, DC 20307 USA. [Lalani, Tahaniyat] Naval Med Ctr Portsmouth, Infect Dis Clin, Portsmouth, VA USA. RP Crum-Cianflone, NF (reprint author), Naval Med Ctr San Diego, Clin Invest Dept KCA, 34800 Bob Wilson Dr,Ste 5, San Diego, CA 92134 USA. EM nancy32red@yahoo.com NR 41 TC 2 Z9 2 U1 2 U2 2 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 2328-8957 J9 OPEN FORUM INFECT DI JI Open Forum Infect. Dis. PD SPR PY 2015 VL 2 IS 2 DI 10.1093/ofid/ofv034 PG 8 WC Infectious Diseases SC Infectious Diseases GA CX6BM UT WOS:000365786200007 ER PT J AU Wang, HK Haynes, R Huang, HZ Dong, LT Atluri, SN AF Wang, Hai-Kun Haynes, Robert Huang, Hong-Zhong Dong, Leiting Atluri, Satya N. TI The Use of High-Performance Fatigue Mechanics and the Extended Kalman/Particle Filters, for Diagnostics and Prognostics of Aircraft Structures SO CMES-COMPUTER MODELING IN ENGINEERING & SCIENCES LA English DT Article DE Diagnostics and prognostics; fatigue mechanics; extended Kalman filter; particle filter ID ANALYSES SGBEM-FEM; ALTERNATING METHOD; SURFACE CRACKS; FRACTURE; GROWTH AB In this paper, we propose an approach for diagnostics and prognostics of damaged aircraft structures, by combing high-performance fatigue mechanics with filtering theories. Fast & accurate deterministic analyses of fatigue crack propagations are carried out, by using the Finite Element Alternating Method (FEAM) for computing SIFs, and by using the newly developed Moving Least Squares (MLS) law for computing fatigue crack growth rates. Such algorithms for simulating fatigue crack propagations are embedded in the computer program Safe-Flaw, which is called upon as a subroutine within the probabilistic framework of filter theories. Both the extended Kalman as well as particle filters are applied in this study, to obtain the statistically optimal and semi-optimal estimates of crack lengths, from a series of noisy measurements of crack-lengths over time. For the specific problem, a simple modification to the particle filter, which can drastically reduce the computational burden, is also proposed. Based on the results of such diagnostic analyses, the prognostics of aerospace structures are thereafter achieved, to estimate the probabilistic distribution of the remaining useful life. By using a simple example of a single-crack near a fastener hole, we demonstrate the concept and effectiveness of the proposed framework. This paper thus forms the scientific foundation for the recently proposed concepts of VRAMS (Virtual Risk-Informed Agile Maneuver Sustainment) and Digital Twins of aerospace vehicles. C1 [Wang, Hai-Kun; Huang, Hong-Zhong] Univ Elect Sci & Technol China, Sch Mech Elect & Ind Engn, Chengdu, Peoples R China. [Wang, Hai-Kun; Dong, Leiting; Atluri, Satya N.] Univ Calif Irvine, Ctr Aerosp Res & Educ, Irvine, CA 92697 USA. [Haynes, Robert] US Army Res Lab, Vehicle Technol Directorate, Adelphi, MD 20783 USA. RP Dong, LT (reprint author), Univ Calif Irvine, Ctr Aerosp Res & Educ, Irvine, CA 92697 USA. EM dong.leiting@gmail.com RI Dong, Leiting /D-7970-2013 OI Dong, Leiting /0000-0003-1460-1846 FU Vehicle Technology Division of the Army Research Labs FX This work, was supported by Vehicle Technology Division of the Army Research Labs. The support and encouragement of Dy Le and Jaret Riddick are thankfully acknowledged. NR 20 TC 4 Z9 4 U1 1 U2 4 PU TECH SCIENCE PRESS PI NORCROSS PA 6825 JIMMY CARTER BLVD, STE 1850, NORCROSS, GA 30071 USA SN 1526-1492 EI 1526-1506 J9 CMES-COMP MODEL ENG JI CMES-Comp. Model. Eng. Sci. PD MAR PY 2015 VL 105 IS 1 BP 1 EP 24 PG 24 WC Engineering, Multidisciplinary; Mathematics, Interdisciplinary Applications SC Engineering; Mathematics GA CT4TQ UT WOS:000362800600001 ER PT J AU Vongsawan, AA Kapatral, V Vaisvil, B Burd, H Serichantalergs, O Venkatesan, MM Mason, CJ AF Vongsawan, Ajchara A. Kapatral, Vinayak Vaisvil, Benjamin Burd, Henry Serichantalergs, Oralak Venkatesan, Malabi M. Mason, Carl J. TI The genome of Shigella dysenteriae strain Sd1617 comparison to representative strains in evaluating pathogenesis SO FEMS MICROBIOLOGY LETTERS LA English DT Article DE Shigella dysenteriae; genome; comparison ID SHIGA-BACILLUS DYSENTERY; LOCUS PATHOGENICITY ISLAND; ESCHERICHIA-COLI; CENTRAL-AMERICA; FLEXNERI 2A; O-ANTIGEN; SECRETION SYSTEMS; IN-VITRO; PROTEIN; SEQUENCE AB We sequenced and analyzed Shigella dysenteriae strain Sd1617 serotype 1 that is widely used as model strain for vaccine design, trials and research. A combination of next-generation sequencing platforms and assembly yielded two contigs representing a chromosome size of 4.34 Mb and the large virulence plasmid of 177 kb. This genome sequence is compared with other Shigella genomes in order to understand gene complexity and pathogenic factors. C1 [Vongsawan, Ajchara A.; Serichantalergs, Oralak; Mason, Carl J.] Armed Forces Res Inst Med Sci, Dept Enter Dis, Bangkok 10400, Thailand. [Kapatral, Vinayak; Vaisvil, Benjamin; Burd, Henry] Igenbio Inc, Chicago, IL 60607 USA. [Venkatesan, Malabi M.] Walter Reed Army Inst Res, Div Bacterial & Rickettsial Dis, Silver Spring, MD 20910 USA. RP Vongsawan, AA (reprint author), Armed Forces Res Inst Med Sci, Dept Enter Dis, 315-6 Rajvithi Rd, Bangkok 10400, Thailand. EM ajcharataa@gmail.com FU National Institute of Allergy and Infectious Diseases (NIAID) under IAA [Y1-AI-4906-03]; US Army Medical Research and Materiel Command (USAM-RMC) FX This work was supported by the National Institute of Allergy and Infectious Diseases (NIAID), under IAA # Y1-AI-4906-03, and by the US Army Medical Research and Materiel Command (USAM-RMC). NR 47 TC 2 Z9 2 U1 0 U2 0 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 0378-1097 EI 1574-6968 J9 FEMS MICROBIOL LETT JI FEMS Microbiol. Lett. PD MAR PY 2015 VL 362 IS 5 AR fnv011 DI 10.1093/femsle/fnv011 PG 8 WC Microbiology SC Microbiology GA CL3XN UT WOS:000356885500012 ER PT J AU Ursano, RJ Kessler, RC Heeringa, SG Cox, KL Naifeh, JA Fullerton, CS Sampson, NA Kao, TC Aliaga, PA Vegella, P Mash, HH Buckley, C Colpe, LJ Schoenbaum, M Stein, MB AF Ursano, Robert J. Kessler, Ronald C. Heeringa, Steven G. Cox, Kenneth L. Naifeh, James A. Fullerton, Carol S. Sampson, Nancy A. Kao, Tzu-Cheg Aliaga, Pablo A. Vegella, Patti Mash, Holly Herberman Buckley, Christina Colpe, Lisa J. Schoenbaum, Michael Stein, Murray B. CA Army STARRS Collaborators TI Nonfatal Suicidal Behaviors in US Army Administrative Records, 2004-2009: Results from the Army Study to Assess Risk and Resilience in Servicemembers (Army STARRS) SO PSYCHIATRY-INTERPERSONAL AND BIOLOGICAL PROCESSES LA English DT Article ID MENTAL-DISORDERS; MILITARY; SOLDIERS; HOSPITALIZATIONS; SURVEILLANCE; AFGHANISTAN; PREVALENCE; DEPRESSION; ADMISSIONS; INJURY AB Objective: Although the U.S. Army suicide rate is known to have risen sharply over the past decade, information about medically documented, nonfatal suicidal behaviors is far more limited. Here we examine trends and sociodemographic correlates of suicide attempts, suspicious injuries, and suicide ideation among regular Army soldiers. Methods: Data come from the Army Study to Assess Risk and Resilience in Servicemembers (Army STARRS) Historical Administrative Data Study (HADS), which integrates administrative records for all soldiers on active duty during the years 2004 through 2009 (n = 1.66 million). Results: We identified 21,740 unique regular Army soldiers with a nonfatal suicidal event documented at some point during the HADS study period. There were substantial increases in the annual incidence rates of suicide attempts (179-400/100,000 person-years) and suicide ideation (557-830/100,000 person-years), but not suspicious injuries. Using hierarchical classification rules to identify the first instance of each soldier's most severe behavior, we found increased risk of all outcomes among those who were female, non-Hispanic White, never married, lower-ranking enlisted, less educated, and of younger age when entering Army service. These sociodemographic associations significantly differed across outcomes, despite some patterns that appear similar. Conclusion: Results provide a broad overview of nonfatal suicidal trends in the U.S. Army during 2004 through 2009 and demonstrate that integration of multiple administrative data systems enriches analysis of the predictors of such events. C1 [Ursano, Robert J.; Naifeh, James A.; Fullerton, Carol S.; Aliaga, Pablo A.; Vegella, Patti; Mash, Holly Herberman; Buckley, Christina] Uniformed Serv Univ Hlth Sci, Dept Psychiat, Ctr Study Traumat Stress, Bethesda, MD 20814 USA. [Kao, Tzu-Cheg] Uniformed Serv Univ Hlth Sci, Dept Prevent Med & Biometr, Bethesda, MD 20814 USA. [Kessler, Ronald C.; Sampson, Nancy A.] Harvard Univ, Sch Med, Dept Hlth Care Policy, Boston, MA 02115 USA. [Heeringa, Steven G.] Univ Michigan, Inst Social Res, Ann Arbor, MI USA. [Cox, Kenneth L.] US Army Publ Hlth Command, Aberdeen Proving Ground, MD USA. [Stein, Murray B.] Univ Calif San Diego, Dept Psychiat, La Jolla, CA 92093 USA. [Stein, Murray B.] Univ Calif San Diego, Dept Family & Prevent Med, La Jolla, CA 92093 USA. [Colpe, Lisa J.] Univ Calif San Diego, La Jolla, CA 92093 USA. [Colpe, Lisa J.] VA San Diego Healthcare Syst, La Jolla, CA USA. [Colpe, Lisa J.; Schoenbaum, Michael] NIMH, Bethesda, MD 20892 USA. RP Ursano, RJ (reprint author), Uniformed Serv Univ Hlth Sci, Dept Psychiat, 4310 Jones Bridge Rd, Bethesda, MD 20814 USA. EM robert.ursano@usuhs.edu RI Wessely, Simon/A-8713-2008 FU Department of the Army; U.S. Department of Health and Human Services, National Institutes of Health/National Institute of Mental Health (NIH/NIMH) [U01MH087981] FX Army STARRS was sponsored by the Department of the Army and funded under cooperative agreement number U01MH087981 with the U.S. Department of Health and Human Services, National Institutes of Health/National Institute of Mental Health (NIH/NIMH). The contents are solely the responsibility of the authors and do not necessarily represent the views of the Department of Health and Human Services, NIMH, the Department of the Army, or the Department of Defense. The Army STARRS Team consists of Co Principal Investigators: Robert J. Ursano, MD (Uniformed Services University of the Health Sciences), and Murray B. Stein, MD, MPH (University of California San Diego and VA San Diego Healthcare System); Site Principal Investigators: Steven Heeringa, PhD (University of Michigan), and Ronald C. Kessler, PhD (Harvard Medical School); National Institute of Mental Health (NIMH) collaborating scientists: Lisa J. Colpe, PhD, MPH, and Michael Schoenbaum, PhD; Army liaisons/consultants: COL Steven Cersovsky, MD, MPH (USAPHC), and Kenneth Cox, MD, MPH (USAPHC); other team members: Pablo A. Aliaga, MA (Uniformed Services University of the Health Sciences); COL David M. Benedek, MD (Uniformed Services University of the Health Sciences); K. Nikki Benevides, MA (Uniformed Services University of the Health Sciences); Susan Borja, PhD (NIMH); Evelyn J. Bromet, PhD (Stony Brook University School of Medicine); Gregory G. Brown, PhD (University of California San Diego); Christina Buckley, BA (Uniformed Services University of the Health Sciences); Laura Campbell-Sills, PhD (University of California San Diego); Catherine L. Dempsey, PhD, MPH (Uniformed Services University of the Health Sciences); Carol S. Fullerton, PhD (Uniformed Services University of the Health Sciences); Nancy Gebler, MA (University of Michigan); Robert K. Gifford, PhD (Uniformed Services University of the Health Sciences); Stephen E. Gilman, ScD (Harvard School of Public Health); Marjan G. Holloway, PhD (Uniformed Services University of the Health Sciences); Paul E. Hurwitz, MPH (Uniformed Services University of the Health Sciences); Sonia Jain, PhD (University of California San Diego); Tzu-Cheg Kao, PhD (Uniformed Services University of the Health Sciences); Karestan C. Koenen, PhD (Columbia University); Lisa Lewandowski-Romps, PhD (University of Michigan); Holly Herberman Mash, PhD (Uniformed Services University of the Health Sciences); James E. McCarroll, PhD, MPH (Uniformed Services University of the Health Sciences); James A. Naifeh, PhD (Uniformed Services University of the Health Sciences); Tsz Hin Hinz Ng, MPH (Uniformed Services University of the Health Sciences); Matthew K. Nock, PhD (Harvard University); Rema Raman, PhD (University of California San Diego); Holly J. Ramsawh, PhD (Uniformed Services University of the Health Sciences); Anthony Joseph Rosellini, PhD (Harvard Medical School); Nancy A. Sampson, BA (Harvard Medical School); LCDR Patcho Santiago, MD, MPH (Uniformed Services University of the Health Sciences); Michaelle Scanlon, MBA (NINTH); Jordan W. Smoller, MD, ScD (Harvard Medical School); Amy Street, PhD (Boston University School of Medicine and VA Boston Healthcare System); Michael L. Thomas, PhD (University of California San Diego); Patti L. Vegella, MS, MA (Uniformed Services University of the Health Sciences); Leming Wang, MS (Uniformed Services University of the Health Sciences); Christina L. Wassel, PhD (University of Pittsburgh); Simon Wessely, FMedSci (King's College London); Hongyan Wu, MPH (Uniformed Services University of the Health Sciences); LTC Gary H.; Wynn, MD (Uniformed Services University of the Health Sciences); Bailey G. Zhang, MS (Uniformed Services University of the Health Sciences); and Alan M. Zaslavsky, PhD (Harvard Medical School). NR 50 TC 4 Z9 4 U1 1 U2 5 PU GUILFORD PUBLICATIONS INC PI NEW YORK PA 370 SEVENTH AVE, SUITE 1200, NEW YORK, NY 10001-1020 USA SN 0033-2747 J9 PSYCHIATRY JI Psychiatry-Interpers. Biol. Process. PD SPR PY 2015 VL 78 IS 1 BP 1 EP 21 DI 10.1080/00332747.2015.1006512 PG 21 WC Psychiatry SC Psychiatry GA CK6DN UT WOS:000356318800001 PM 26168022 ER PT J AU Burmeister, DM Becerra, S Laborde, A Natesan, S Christy, RJ AF Burmeister, D. M. Becerra, S. Laborde, A. Natesan, S. Christy, R. J. TI PEGYLATED FIBRIN HYDROGELS FOR DELIVERY OF ADIPOSE-DERIVED STEM CELLS TO DEEP-PARTIAL THICKNESS BURN WOUNDS SO WOUND REPAIR AND REGENERATION LA English DT Meeting Abstract C1 [Burmeister, D. M.; Becerra, S.; Laborde, A.; Natesan, S.; Christy, R. J.] US Army Inst Surg Res, Ft Sam Houston, TX USA. NR 0 TC 0 Z9 0 U1 1 U2 2 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1067-1927 EI 1524-475X J9 WOUND REPAIR REGEN JI Wound Repair Regen. PD MAR-APR PY 2015 VL 23 IS 2 BP A17 EP A17 PG 1 WC Cell Biology; Dermatology; Medicine, Research & Experimental; Surgery SC Cell Biology; Dermatology; Research & Experimental Medicine; Surgery GA CK7YE UT WOS:000356452000018 ER PT J AU Natesan, S Baker, BA Coronado, RE Christy, RJ AF Natesan, S. Baker, B. A. Coronado, R. E. Christy, R. J. TI HUMAN BLOOD PLASMA-DECELLULARIZED ADIPOSE TISSUE COMPOSITE WITH MESENCHYMAL STEM CELLS CREATES A VASCULARIZED DERMAL SUBSTITUTE SO WOUND REPAIR AND REGENERATION LA English DT Meeting Abstract C1 [Natesan, S.; Baker, B. A.; Coronado, R. E.; Christy, R. J.] US Army Inst Surg Res, San Antionio, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1067-1927 EI 1524-475X J9 WOUND REPAIR REGEN JI Wound Repair Regen. PD MAR-APR PY 2015 VL 23 IS 2 BP A33 EP A33 PG 1 WC Cell Biology; Dermatology; Medicine, Research & Experimental; Surgery SC Cell Biology; Dermatology; Research & Experimental Medicine; Surgery GA CK7YE UT WOS:000356452000093 ER PT J AU Roy, D Kowalczewski, C Burmeister, D Isaac, K Burnett, L Tomblyn, S Christy, R AF Roy, D. Kowalczewski, C. Burmeister, D. Isaac, K. Burnett, L. Tomblyn, S. Christy, R. TI ANTIBIOTIC-LOADED KERATIN HYDROGELS PREVENT INFECTION IN A PORCINE PARTIAL-THICKNESS THERMAL BURN SO WOUND REPAIR AND REGENERATION LA English DT Meeting Abstract C1 [Roy, D.; Kowalczewski, C.; Burmeister, D.; Isaac, K.; Christy, R.] US Army Inst Surg Res, Ft Sam Houston, TX USA. [Roy, D.; Kowalczewski, C.; Burnett, L.; Tomblyn, S.] KeraNetics LLC, Winston Salem, NC USA. RI Saul, Justin/I-1765-2016 NR 0 TC 0 Z9 0 U1 0 U2 2 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1067-1927 EI 1524-475X J9 WOUND REPAIR REGEN JI Wound Repair Regen. PD MAR-APR PY 2015 VL 23 IS 2 BP A37 EP A37 PG 1 WC Cell Biology; Dermatology; Medicine, Research & Experimental; Surgery SC Cell Biology; Dermatology; Research & Experimental Medicine; Surgery GA CK7YE UT WOS:000356452000112 ER PT J AU Wehmeyer, JL Friedrich, E Natesan, S Christy, R AF Wehmeyer, J. L. Friedrich, E. Natesan, S. Christy, R. TI SCCO2-TREATED AMNIOTIC MEMBRANE-BASED EPITHELIAL SUBSTITUTE FOR CUTANEOUS WOUND HEALING SO WOUND REPAIR AND REGENERATION LA English DT Meeting Abstract C1 [Wehmeyer, J. L.; Natesan, S.; Christy, R.] US Army Inst Surg Res, San Antonio, TX USA. [Friedrich, E.] Carnegie Mellon, Pittsburgh, PA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1067-1927 EI 1524-475X J9 WOUND REPAIR REGEN JI Wound Repair Regen. PD MAR-APR PY 2015 VL 23 IS 2 BP A44 EP A44 PG 1 WC Cell Biology; Dermatology; Medicine, Research & Experimental; Surgery SC Cell Biology; Dermatology; Research & Experimental Medicine; Surgery GA CK7YE UT WOS:000356452000145 ER PT J AU Yen, NT Liu, W Hanh, HD Chang, NY Duong, TN Gibbons, RV Marks, F Thu, NA Hong, NM Park, JK Tuan, PA Nisalak, A Clemens, JD Xu, ZY AF Nguyen Thu Yen Liu, Wei Hoang Duc Hanh Na Yoon Chang Tran Nhu Duong Gibbons, Robert V. Marks, Florian Nghiem Anh Thu Nguyen Minh Hong Park, Jin Kyung Tuan, Pham Anh Nisalak, Ananda Clemens, John D. Xu, Zhi-yi TI A Model Immunization Programme to Control Japanese Encephalitis in Viet Nam SO JOURNAL OF HEALTH POPULATION AND NUTRITION LA English DT Article DE Demonstration project; Effectiveness study; Immunization; Japanese encephalitis; Vaccines ID CEREBROSPINAL-FLUID; EPIDEMIOLOGY; VIRUS AB In Viet Nam, an inactivated, mouse brain-derived vaccine for Japanese encephalitis (JE) has been given exclusively to <= 5 years old children in 3 paediatric doses since 1997. However, JE incidence remained high, especially among children aged 5-9 years. We conducted a model JE immunization programme to assess the feasibility and impact of JE vaccine administered to 1-9 year(s) children in 3 standard-dose regimen: paediatric doses for children aged < 3 years and adult doses for those aged >= 3 years. Of the targeted children, 96.2% were immunized with >= 2 doses of the vaccine. Compared to the national immunization programme, JE incidence rate declined sharply in districts with the model programme (11.32 to 0.87 per 100,000 in pre- versus post-vaccination period). The rate of reduction was most significant in the 5-9 years age-group. We recommend a policy change to include 5-9 years old children in the catch-up immunization campaign and administer a 4th dose to those aged 5-9 years, who had received 3 doses of the vaccine during the first 2-3 years of life. C1 [Nguyen Thu Yen; Tran Nhu Duong; Nghiem Anh Thu; Nguyen Minh Hong; Tuan, Pham Anh] NIHE, Hanoi, Vietnam. [Liu, Wei; Na Yoon Chang; Marks, Florian; Park, Jin Kyung; Clemens, John D.; Xu, Zhi-yi] Int Vaccine Inst, Seoul 151818, South Korea. [Hoang Duc Hanh] Prevent Med Ctr, Hanoi, HaTay Province, Vietnam. [Nisalak, Ananda] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Xu, Zhi-yi] Fudan Univ, Sch Publ Hlth, Dept Epidemiol, Shanghai 200433, Peoples R China. RP Liu, W (reprint author), Int Vaccine Inst, Dept Translat Res, Seoul, South Korea. EM wei_liu@post.harvard.edu FU Korean International Cooperation Agency (KOICA) [2003-001] FX Financial support for this project was provided by the Korean International Cooperation Agency (KOICA) by contract no. 2003-001. The authors thank colleagues from HaTay Provincial Hospital, and Hanoi National Pediatric Hospital for their participation and contribution in the investigation. We thank doctors working at the commune health centres in HaTay for their help with the mass immunization campaign. NR 15 TC 0 Z9 0 U1 0 U2 0 PU ICDDR B PI DHAKA PA MOHAKHALI, 1212 DHAKA, BANGLADESH SN 1606-0997 EI 2072-1315 J9 J HEALTH POPUL NUTR JI J. Heatlh Popul. Nutr. PD MAR PY 2015 VL 33 IS 1 BP 207 EP 213 PG 7 WC Environmental Sciences; Public, Environmental & Occupational Health SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health GA CJ2AI UT WOS:000355286100021 PM 25995736 ER PT J AU Yoon, EJ Chabane, YN Goussard, S Snesrud, E Courvalin, P De, E Grillot-Courvalin, C AF Yoon, Eun-Jeong Chabane, Yassine Nait Goussard, Sylvie Snesrud, Erik Courvalin, Patrice De, Emmanuelle Grillot-Courvalin, Catherine TI Contribution of Resistance-Nodulation-Cell Division Efflux Systems to Antibiotic Resistance and Biofilm Formation in Acinetobacter baumannii SO MBIO LA English DT Article ID GRAM-NEGATIVE BACTERIA; MULTIDRUG-RESISTANCE; GENOME SEQUENCE; MULTIPLE ANTIBIOTICS; ESCHERICHIA-COLI; ABIOTIC SURFACES; VIBRIO-CHOLERAE; SUICIDE VECTOR; PUMPS; ADEIJK AB Acinetobacter baumannii is a nosocomial pathogen of increasing importance due to its multiple resistance to antibiotics and ability to survive in the hospital environment linked to its capacity to form biofilms. To fully characterize the contribution of AdeABC, AdeFGH, and AdeIJK resistance-nodulation-cell division (RND)-type efflux systems to acquired and intrinsic resistance, we constructed, from an entirely sequenced susceptible A. baumannii strain, a set of isogenic mutants overexpressing each system following introduction of a point mutation in their cognate regulator or a deletion for the pump by allelic replacement. Pairwise comparison of every derivative with the parental strain indicated that AdeABC and AdeFGH are tightly regulated and contribute to acquisition of antibiotic resistance when overproduced. AdeABC had a broad substrate range, including beta-lactams, fluoroquinolones, tetracyclines-tigecycline, macrolides-lincosamides, and chloramphenicol, and conferred clinical resistance to aminoglycosides. Importantly, when combined with enzymatic resistance to carbapenems and aminoglycosides, this pump contributed in a synergistic fashion to the level of resistance of the host. In contrast, AdeIJK was expressed constitutively and was responsible for intrinsic resistance to the same major drug classes as AdeABC as well as antifolates and fusidic acid. Surprisingly, overproduction of AdeABC and AdeIJK altered bacterial membrane composition, resulting in decreased biofilm formation but not motility. Natural transformation and plasmid transfer were diminished in recipients overproducing AdeABC. It thus appears that alteration in the expression of efflux systems leads to multiple changes in the relationship between the host and its environment, in addition to antibiotic resistance. IMPORTANCE Increased expression of chromosomal genes for RND-type efflux systems plays a major role in bacterial multidrug resistance. Acinetobacter baumannii has recently emerged as an important human pathogen responsible for epidemics of hospital-acquired infections. Besides its remarkable ability to horizontally acquire resistance determinants, it has a broad intrinsic resistance due to low membrane permeability, endogenous resistance genes, and antibiotic efflux. The study of isogenic mutants from a susceptible A. baumannii clinical isolate overproducing or deleted for each of the three major RND-type pumps demonstrated their major contribution to intrinsic resistance and to the synergism between overproduction of an efflux system and acquisition of a resistance gene. We have also shown that modulation of expression of the structural genes for the efflux systems results in numerous alterations in membrane-associated cellular functions, in particular, in a decrease in biofilm formation and resistance gene acquisition. C1 [Yoon, Eun-Jeong; Goussard, Sylvie; Courvalin, Patrice; Grillot-Courvalin, Catherine] Inst Pasteur, Unite Agents Antibacteriens, Paris, France. [Chabane, Yassine Nait; De, Emmanuelle] Univ Rouen, Lab Polymeres, Biopolymeres, Surfaces,UMR 6270, Mont St Aignan, France. [Chabane, Yassine Nait; De, Emmanuelle] Univ Rouen, IRIB, FR CNRS 3038, Mont St Aignan, France. [Snesrud, Erik] Walter Reed Army Inst Res, Multidrug Resistant Organism Repository & Surveil, Silver Spring, MD USA. RP Grillot-Courvalin, C (reprint author), Inst Pasteur, Unite Agents Antibacteriens, Paris, France. EM ccourval@pasteur.fr FU Reckitt-Benckiser FX E.-J.Y. was supported by an unrestricted grant from Reckitt-Benckiser. NR 60 TC 21 Z9 22 U1 3 U2 15 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 2150-7511 J9 MBIO JI mBio PD MAR-APR PY 2015 VL 6 IS 2 AR e00309-15 DI 10.1128/mBio.00309-15 PG 13 WC Microbiology SC Microbiology GA CJ2KE UT WOS:000355312400100 ER PT J AU Goodson, LP AF Goodson, Larry P. TI The US and Afghanistan after 2014 SO ASIAN SURVEY LA English DT Article DE Afghanistan; US interests, policies, and strategies; Great Game; Taliban; insurgency AB The attacks of 9/11 spurred the U.S. to pursue national security interests in Afghanistan through expensive, overlapping strategies. The Afghan War helped elicit changes in the region that produced new American interests there. Because of a modern "Great Game" between regional and global actors in and around Afghanistan, the U.S. cannot afford to withdraw from the region. C1 US Army War Coll, Middle East Studies, Carlisle, PA 17013 USA. RP Goodson, LP (reprint author), US Army War Coll, Middle East Studies, Carlisle, PA 17013 USA. EM larry.p.goodson.civ@mail.mil NR 35 TC 0 Z9 0 U1 1 U2 5 PU UNIV CALIFORNIA PRESS PI OAKLAND PA 155 GRAND AVE, SUITE 400, OAKLAND, CA 94612-3758 USA SN 0004-4687 EI 1533-838X J9 ASIAN SURV JI Asian Surv. PD MAR-APR PY 2015 VL 55 IS 2 BP 249 EP 272 DI 10.1525/AS.2.015.55.2.249 PG 24 WC Area Studies SC Area Studies GA CI3RE UT WOS:000354664300002 ER PT J AU Baral, SD Ketende, S Schwartz, S Orazulike, I Ugoh, K Peel, SA Ake, J Blattner, W Charurat, M AF Baral, Stefan D. Ketende, Sosthenes Schwartz, Sheree Orazulike, Ifeanyi Ugoh, Kelechi Peel, Sheila A. Ake, Julie Blattner, William Charurat, Manhattan CA TRUST Study Grp TI Evaluating Respondent-Driven Sampling as an Implementation Tool for Universal Coverage of Antiretroviral Studies Among Men Who Have Sex With Men Living With HIV SO JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES LA English DT Article DE Antiretroviral treatment; HIV; men who have sex with men; Nigeria; Africa; Respondent-driven sampling ID TRANSGENDER WOMEN; UNITED-STATES; BLACK-MEN; PREVENTION; TRANSMISSION; INFECTION; EPIDEMIOLOGY; POPULATIONS; CHALLENGES; INITIATION AB Introduction: The TRUST model based on experimental and observational data posits that integration of HIV prevention and universal coverage of antiretroviral treatment at a trusted community venue provides a framework for achieving effective reduction in HIV-related morbidity and mortality among men who have sex with men (MSM) living with HIV, as well as reducing HIV incidence. The analyses presented here evaluate the utility of respondent-driven sampling as an implementation tool for engaging MSM in the TRUST intervention. Methods: The TRUST integrated prevention and treatment model was established at a trusted community center serving MSM in Abuja, Nigeria. Five seeds have resulted in 3-26 waves of accrual between March 2013 and August 2014, with results presented here characterizing HIV burden and engagement in HIV care for 722 men across study recruitment waves. For analytic purposes, the waves were collapsed into 5 groups: 4 equally spaced (0-4, 5-9, 10-14, and 15-19) and 1 ranging from the 20th to the 26th wave with significance assessed using Pearson chi(2) test. Results: In earlier waves, MSM were more likely to have reported testing for HIV (82.9% in waves 0-4, 47.7% in waves 20-26; P < 0.01). In addition, biologically confirmed HIV prevalence decreased from an average of 59.1% to 42.9% (P < 0.05) in later waves. In earlier waves, about 80% of participants correctly reported their HIV status as compared with less than 25% in the later waves (P < 0.01). Finally, participants reporting being on ART decreased from 50% to 22.2% in later waves (P < 0.01). Conclusions: Implementation science studies focused on demonstrating impact of universal HIV treatment programs among people living with HIV necessitate different accrual methods than those focused on preventing HIV acquisition. Here, respondent-driven sampling was shown to be an efficient method for reaching marginalized populations of MSM living with HIV in Nigeria, and engaging them in universal HIV treatment services. C1 [Baral, Stefan D.; Ketende, Sosthenes; Schwartz, Sheree] JHSPH, Key Populat Program, Ctr Publ Hlth & Human Rights, Dept Epidemiol, Baltimore, MD USA. [Orazulike, Ifeanyi] ICARH, Abuja, Nigeria. [Ugoh, Kelechi] Improving Mens Hlth Initiat, Abuja, Nigeria. [Peel, Sheila A.; Ake, Julie] US Mil HIV Res Project, Silver Spring, MD USA. [Peel, Sheila A.; Ake, Julie] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD USA. [Blattner, William; Charurat, Manhattan] Univ Maryland, Div Epidemiol & Prevent, Baltimore, MD 21201 USA. RP Baral, SD (reprint author), E7146,615 N Wolfe St, Baltimore, MD 21205 USA. EM sbaral@jhu.edu FU US National Institutes of Health [R01MH099001-01]; US Military HIV Research Program [W81XWH-07-2-0067]; Fogarty AITRP [D43TW01041]; HHS/Centers for Disease Control and Prevention (CDC), Global AIDS Program [U2G IPS000651]; IHVN; Johns Hopkins University Center for AIDS Research [P30AI094189] FX Supported by the US National Institutes of Health under award number R01MH099001-01. This study is also supported by funds from the US Military HIV Research Program (Grant No. W81XWH-07-2-0067), Fogarty AITRP (D43TW01041), and the President's Emergency Plan for AIDS Relief through cooperative agreement U2G IPS000651 from the HHS/Centers for Disease Control and Prevention (CDC), Global AIDS Program with IHVN. Support provided to SB by the Johns Hopkins University Center for AIDS Research (P30AI094189). NR 39 TC 8 Z9 8 U1 1 U2 5 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1525-4135 EI 1077-9450 J9 JAIDS-J ACQ IMM DEF JI JAIDS PD MAR 1 PY 2015 VL 68 SU 2 BP S107 EP S113 PG 7 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA CH6CJ UT WOS:000354123100006 PM 25723974 ER PT J AU Abuzneid, AS Sobh, T Faezipour, M Mahmood, A James, J AF Abuzneid, Abdel-Shakour Sobh, Tarek Faezipour, Miad Mahmood, Ausif James, John TI Fortified Anonymous Communication Protocol for Location Privacy in WSN: A Modular Approach SO SENSORS LA English DT Article DE WSN; anonymity; privacy; source location privacy; sink privacy; contextual privacy; routing privacy; temporal privacy; traffic privacy; observability; safety period ID WIRELESS SENSOR NETWORKS; INTERNET; THINGS AB Wireless sensor network (WSN) consists of many hosts called sensors. These sensors can sense a phenomenon (motion, temperature, humidity, average, max, min, etc.) and represent what they sense in a form of data. There are many applications for WSNs including object tracking and monitoring where in most of the cases these objects need protection. In these applications, data privacy itself might not be as important as the privacy of source location. In addition to the source location privacy, sink location privacy should also be provided. Providing an efficient end-to-end privacy solution would be a challenging task to achieve due to the open nature of the WSN. The key schemes needed for end-to-end location privacy are anonymity, observability, capture likelihood, and safety period. We extend this work to allow for countermeasures against multi-local and global adversaries. We present a network model protected against a sophisticated threat model: passive /active and local/multi-local/global attacks. This work provides a solution for end-to-end anonymity and location privacy as well. We will introduce a framework called fortified anonymous communication (FAC) protocol for WSN. C1 [Abuzneid, Abdel-Shakour; Sobh, Tarek; Faezipour, Miad; Mahmood, Ausif] Univ Bridgeport, Comp Sci & Engn Dept, Bridgeport, CT 06604 USA. [James, John] US Mil Acad, Dept Elect Engn & Comp Sci, West Point, NY 10996 USA. RP Abuzneid, AS (reprint author), Univ Bridgeport, Comp Sci & Engn Dept, Bridgeport, CT 06604 USA. EM abuzneid@bridgeport.edu; sobh@bridgeport.edu; mfaezipo@bridgeport.edu; Mahmood@bridgeport.edu; john.james@usma.edu NR 49 TC 5 Z9 5 U1 1 U2 18 PU MDPI AG PI BASEL PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND SN 1424-8220 J9 SENSORS-BASEL JI Sensors PD MAR PY 2015 VL 15 IS 3 BP 5820 EP 5864 DI 10.3390/s150305820 PG 45 WC Chemistry, Analytical; Electrochemistry; Instruments & Instrumentation SC Chemistry; Electrochemistry; Instruments & Instrumentation GA CH6QK UT WOS:000354160900064 PM 25763649 ER PT J AU Lim, R AF Lim, Robert TI Comment on: Laparoscopic sleeve gastrectomy in patients over 60 years: impact of age on weight loss and co-morbidity improvement SO SURGERY FOR OBESITY AND RELATED DISEASES LA English DT Editorial Material C1 Tripler Army Med Ctr, Dept Surg, Honolulu, HI 96859 USA. RP Lim, R (reprint author), Tripler Army Med Ctr, Dept Surg, Honolulu, HI 96859 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1550-7289 EI 1878-7533 J9 SURG OBES RELAT DIS JI Surg. Obes. Relat. Dis. PD MAR-APR PY 2015 VL 11 IS 2 BP 301 EP 302 PG 2 WC Surgery SC Surgery GA CI0HU UT WOS:000354418500009 PM 25066160 ER PT J AU Theiling, CH Janvrin, JA Hendrickson, J AF Theiling, Charles H. Janvrin, Jeffrey A. Hendrickson, Jon TI Upper Mississippi River restoration: implementation, monitoring, and learning since 1986 SO RESTORATION ECOLOGY LA English DT Article DE adaptive management; backwater; habitat suitability model; island; wetland ID CONNECTIVITY; MANAGEMENT; FISH; POPULATION; BACKWATERS; WATERFOWL; ILLINOIS; HABITAT; SYSTEM; OXYGEN AB Upper Mississippi River Restoration (UMRR) was implemented to monitor environmental status and trends and restore degraded habitat. There was little experience conducting restoration in large rivers, and engineering and ecological integration evolved through project implementation. Loss of depth in backwaters and side channels, excessive biological oxygen demand, increased currents, and low water temperatures were common symptoms of backwater eutrophication that were primary objectives for implementing UMRR. Biological outcome monitoring was initially funded for six projects using the most common methods to restore aquatic and wetland habitat. UMRR island construction occurred as four generations of learning. Current plans represent a comprehensive restoration approach including: physical process modeling (i.e. hydraulic and wind-wave modeling) of existing conditions and alternative restoration measures. Habitat Rehabilitation and Enhancement Projects, fish response monitoring validated winter habitat suitability models. Long term fish population monitoring indicates sustainable recovery, and now population interaction among restored lakes is under investigation. Isolated wetland management in Illinois River backwater lakes can achieve bottom consolidation that promotes emergent wetland habitat response that migratory waterfowl exploit in large numbers. Adult fish movement between the river and management units is restricted to flood stage or through control structures and post-project movements into the lake for overwintering were not apparent. The lack of Illinois River overwintering habitat is shown by an abundance of young fish and few older fish in status and trends monitoring. Upper Mississippi River System ecosystem restoration practitioners have implemented ecosystem restoration science and practice in a manner that exemplifies the best intent of adaptive management. C1 [Theiling, Charles H.] US Army, Corps Engineers, Rock Isl, IL 61204 USA. [Janvrin, Jeffrey A.] Wisconsin Dept Nat Resources, La Crosse, WI 54601 USA. [Hendrickson, Jon] US Army, Corps Engineers, St Paul, MN 55101 USA. RP Theiling, CH (reprint author), US Army, Corps Engineers, Rock Isl, IL 61204 USA. EM charles.h.theiling@usace.army.mil FU U.S. Army Corps of Engineers, Upper Mississippi River Restoration FX U.S. Army Corps of Engineers, Upper Mississippi River Restoration has supported restoration, monitoring, and science for over 25 years and contributed financial support for this review. NR 49 TC 6 Z9 6 U1 5 U2 33 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1061-2971 EI 1526-100X J9 RESTOR ECOL JI Restor. Ecol. PD MAR PY 2015 VL 23 IS 2 BP 157 EP 166 DI 10.1111/rec.12170 PG 10 WC Ecology SC Environmental Sciences & Ecology GA CH3WU UT WOS:000353962500009 ER PT J AU Nottage, D Corns, S Soylemezoglu, A Kinnevan, K AF Nottage, Dustin Corns, Steven Soylemezoglu, Ahmet Kinnevan, Kurt TI A SysML Framework for Modeling Contingency Basing SO SYSTEMS ENGINEERING LA English DT Article DE model-based systems engineering; OMG SysML; contingency basing AB Contingency basing presents a planner with numerous design decisions driven by multiple design criteria such as the number of soldiers, base permanency, base location, and other factors. The operational environment of the base is not static either; design requirements change as the mission changes. In this work, we introduce a model-based systems engineering approach to elicit design and operational needs while dealing with the design complexity of constructing a contingency base. The model includes the key facility types that can make a contingency base, interactions between facility types, and required utilities for each facility type. The model elements are kept at an abstract level so the details can be altered as required by the customer needs. Pairing the model with an external analysis tool allows for quick development and testing. Properties of the facility types can be altered either in the model or the analysis tool, and reflected in both. Using the model-based systems engineering concepts of reusability, these elements can be saved and re-used in future base designs allowing for a rapid and adaptable design process. In addition, the sharing of information visually with Object Management Group's Systems Modeling Language (TM) diagrams enhances the ability to collaborate with nonengineering subject matter experts within the design domain. By graphically showing the conditions and layout of the proposed contingency base, Department of Defense personnel not trained in modeling and simulation were able to interact with the engineering designs and identify gaps in the proposed architecture. (C) 2015 Wiley Periodicals, Inc. C1 [Nottage, Dustin; Corns, Steven] Missouri Univ Sci & Technol, Engn Management & Syst Engn, Rolla, MO 65409 USA. [Soylemezoglu, Ahmet; Kinnevan, Kurt] Engineer Res & Dev Ctr, Construct Engn Res Lab, Champaign, IL 61826 USA. RP Corns, S (reprint author), Missouri Univ Sci & Technol, Engn Management & Syst Engn, 223 EMGT Bldg, Rolla, MO 65409 USA. EM cornss@mst.edu NR 33 TC 0 Z9 0 U1 2 U2 13 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1098-1241 EI 1520-6858 J9 SYSTEMS ENG JI Syst. Eng. PD MAR PY 2015 VL 18 IS 2 BP 162 EP 177 DI 10.1002/sys.21297 PG 16 WC Engineering, Industrial; Operations Research & Management Science SC Engineering; Operations Research & Management Science GA CI3AQ UT WOS:000354620200004 ER PT J AU Steele, SR Varma, MG Prichard, D Bharucha, AE Vogler, SA Erdogan, A Rao, SSC Lowry, AC Lange, EO Hall, GM Bleier, JIS Senagore, AJ Maykel, J Chan, SY Paquette, IM Audett, MC Bastawrous, A Umamaheswaran, P Fleshman, JW Caton, G O'Brien, BS Nelson, JM Steiner, A Garely, A Noor, N Desrosiers, L Kelley, R Jacobson, NS Rahimi, S AF Steele, Scott R. Varma, Madhulika G. Prichard, David Bharucha, Adil E. Vogler, Sarah A. Erdogan, Askin Rao, Satish S. C. Lowry, Ann C. Lange, Erin O. Hall, Glen M. Bleier, Joshua I. S. Senagore, Anthony J. Maykel, Justin Chan, Sook Y. Paquette, Ian M. Audett, Marie C. Bastawrous, Amir Umamaheswaran, Preetha Fleshman, James W. Caton, Gentry O'Brien, Brendan S. Nelson, Jeffery M. Steiner, Ari Garely, Alan Noor, Nabila Desrosiers, Laurephile Kelley, Robert Jacobson, Nina S. Rahimi, Salma TI The evolution of evaluation and management of urinary or fecal incontinence and pelvic organ prolapse SO CURRENT PROBLEMS IN SURGERY LA English DT Review ID LAPAROSCOPIC VENTRAL RECTOPEXY; EXTERNAL RECTAL PROLAPSE; PERINEAL STAPLED PROLAPSE; QUALITY-OF-LIFE; POSTERIOR VAGINAL COMPARTMENT; COST-EFFECTIVENESS ANALYSIS; SACRAL NERVE-STIMULATION; LONG-TERM; SURGICAL-MANAGEMENT; ABDOMINAL RECTOPEXY C1 [Steele, Scott R.] Uniformed Serv Univ Hlth Sci, Surg, Ft Lewis, WA 98433 USA. [Steele, Scott R.] Madigan Army Med Ctr, Colon & Rectal Surg, Ft Lewis, WA USA. [Varma, Madhulika G.] Univ Calif San Francisco, Sect Colorectal Surg, San Francisco, CA 94143 USA. [Prichard, David] Mayo Clin, GI Motil, Rochester, MN USA. [Bharucha, Adil E.] Mayo Clin, Med, Rochester, MN USA. [Vogler, Sarah A.] Univ Minnesota, Surg, Edina, MN USA. [Erdogan, Askin] Georgia Regents Univ, Augusta, GA USA. [Rao, Satish S. C.] Georgia Regents Univ, Digest Hlth Ctr, Augusta, GA USA. [Lowry, Ann C.] Univ Minnesota, Surg, St Paul, MN 55108 USA. [Lange, Erin O.] Univ Washington, Surg, Seattle, WA 98195 USA. [Hall, Glen M.] Case Western Reserve Univ, Cleveland, OH 44106 USA. [Bleier, Joshua I. S.] Univ Penn, Perelman Sch Med, Surg, Philadelphia, PA 19104 USA. [Senagore, Anthony J.] Case Western Reserve Univ, Sch Med, Dept Surg, Cleveland, OH 44106 USA. [Maykel, Justin; Chan, Sook Y.] Univ Massachusetts, Mem Med Ctr, Dept Surg, Worcester, MA 01605 USA. [Paquette, Ian M.] Univ Cincinnati, Coll Med, Dept Surg, Surg, Cincinnati, OH USA. [Audett, Marie C.] Univ Cincinnati, Coll Med, Dept Surg, Cincinnati, OH USA. [Umamaheswaran, Preetha] Swedish Med Ctr, Colon & Rectal Surg, Seattle, WA USA. [Fleshman, James W.] Baylor Univ, Med Ctr, Dept Surg, Dallas, TX 75246 USA. [Caton, Gentry] Baylor Univ, Med Ctr, Colon & Rectal Surg, Dallas, TX USA. [O'Brien, Brendan S.] US Navy, Med Corps, LT, Dept Surg,Walter Reed Natl Mil Med Ctr, Washington, DC USA. [Nelson, Jeffery M.] US Army, COL, MC, Dept Surg,Walter Reed Natl Mil Med Ctr, Bethesda, MD USA. [Steiner, Ari] South Nassau Commun Hosp, Radiol, Oceanside, NY USA. [Garely, Alan] Icahn Sch Med Mt Sinai, Obstet Gynecol & Reprod Med, New York, NY 10029 USA. [Noor, Nabila] Icahn Sch Med Mt Sinai, Obstet & Gynecol, New York, NY 10029 USA. [Desrosiers, Laurephile; Kelley, Robert; Jacobson, Nina S.] Icahn Sch Med Mt Sinai, Female Pelv Med & Reconstruct Surg, New York, NY 10029 USA. [Rahimi, Salma] Mt Sinai Hosp, Obstet & Gynecol, New York, NY 10029 USA. RP Steele, SR (reprint author), Uniformed Serv Univ Hlth Sci, Surg, Ft Lewis, WA 98433 USA. NR 163 TC 3 Z9 3 U1 0 U2 6 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0011-3840 EI 1535-6337 J9 CURR PROB SURG JI Curr. Probl. Surg. PD MAR PY 2015 VL 52 IS 3 BP 92 EP 136 DI 10.1067/j.cpsurg.2015.02.001 PG 45 WC Surgery SC Surgery GA CH5KC UT WOS:000354073500002 PM 25933741 ER PT J AU Jain, RB AF Jain, Ram B. TI Association of arsenic exposure with smoking, alcohol, and caffeine consumption: Data from NHANES 2005-2010 SO ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY LA English DT Article DE Gender; Age; Race/ethnicity; Arsenobetaine; Dimethylarsonic acid ID CARDIOVASCULAR-DISEASE; DRINKING-WATER; RISK; CANCER; POPULATION; CIGARETTES; TOBACCO; BANGLADESH; SPECIATION; WORKERS AB Association of arsenic exposure with smoking, alcohol, and caffeine consumption was investigated. Data from National Health and Nutrition Examination Survey for the years 2005-2010 were used for this investigation. Urinary levels of total arsenic (UAS) and dimethylarsonic acid (UDMA) were evaluated for children aged 6-12 years and adolescents and adults aged >= 12 years. Urinary levels of arsenobetaine (UAB) were evaluated for adolescents and adults only. Regression models were fitted for log transformed values of UAB, UAS, and UDMA. For the models for children, however, gender, race/ethnicity, SES, and fish/shell fish consumption during the last 30 days were the only independent variables that were included in the models. Nonsmokers were found to have higher levels of UAS and UDMA than smokers. Elevated levels of UAB, UAS, and UDMA were associated with higher amounts of daily alcohol consumption. The associations were in the opposite direction for daily caffeine consumption. Females were found to have statistically significantly lower adjusted levels of UDMA than males for those aged >= 12 years. Irrespective of age, those with unclassified race/ethnicity had the highest levels of UAB, UAS, and UDMA and non-Hispanic whites had the lowest levels. Adolescents had the higher levels of UAB, UAS, and UDMA than adults. Higher SES was associated with higher levels of UAB, UAS, and UDMA among adolescents and adults. Irrespective of age, fish consumption was associated with higher levels of UAB, UAS, and UDMA. Published by Elsevier B.V. C1 [Jain, Ram B.] Womack Army Med Ctr, Ft Bragg, NC 28310 USA. [Jain, Ram B.] Empiristat Inc, Mt Airy, MD USA. RP Jain, RB (reprint author), Womack Army Med Ctr, Dept Clin Invest, Ft Bragg, NC 28310 USA. EM ram.b.jain.ctr@mail.mil NR 28 TC 2 Z9 2 U1 2 U2 5 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1382-6689 EI 1872-7077 J9 ENVIRON TOXICOL PHAR JI Environ. Toxicol. Pharmacol. PD MAR PY 2015 VL 39 IS 2 BP 651 EP 658 DI 10.1016/j.etap.2015.01.011 PG 8 WC Environmental Sciences; Pharmacology & Pharmacy; Toxicology SC Environmental Sciences & Ecology; Pharmacology & Pharmacy; Toxicology GA CH3KP UT WOS:000353929900020 PM 25682010 ER PT J AU Jain, RB AF Jain, Ram B. TI Levels of caffeine and its metabolites among US smokers and nonsmokers SO ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY LA English DT Article DE Caffeine intake; Race/ethnicity; Smoking; CYP1A2 ID TYPE-2 DIABETES-MELLITUS; DOSE-RESPONSE METAANALYSIS; COFFEE CONSUMPTION; BLOOD-PRESSURE; PARKINSONS-DISEASE; PROSPECTIVE COHORT; LIVER-CIRRHOSIS; CYP1A2 ACTIVITY; HEART-DISEASE; RISK AB Data from National Health and Nutrition Examination Survey for the years 2009-2010 were used to estimate the levels of caffeine and 14 of its metabolite among U.S. smokers and nonsmokers after adjustments were made for other factors that affect observed caffeine levels. In this study, when adjusted for daily caffeine intake, adjusted levels (AGM) of caffeine and its metabolites were not found to be statistically significantly different between smokers and nonsmokers. AGMs for caffeine and all of its metabolites were found to be statistically significantly higher (p < 0.01) among females aged >= 12 years than males. For caffeine, 1,3-dimethylxanthine, and 1,7-dimethylxanthine, those aged >= 20 years had statistically significantly higher (p < 0.01) AGM than those aged 12-19 years but the reverse was true for 7-methylxanthine and 3,7-dimethylxanthine (p <= 0.02). The order of the AGMs by race/ethnicity was non-Hispanic whites > Hispanics > non-Hispanic blacks and most of the differences were statistically significant, at least between non-Hispanic whites and non-Hispanic blacks (p < 0.01). In general, there was a statistically significant positive association between the levels of caffeine and its metabolites and body mass index as well as daily caffeine intake. However, the levels of 7-methylxanthine were negatively associated with body mass index. (C) 2015 Elsevier B.V. All rights reserved. C1 [Jain, Ram B.] Womack Army Med Ctr, Ft Bragg, NC 28310 USA. [Jain, Ram B.] Empiristat Inc, Mt Airy, MD USA. RP Jain, RB (reprint author), Womack Army Med Ctr, Dept Clin Invest, 2817 Reilly Rd, Ft Bragg, NC 28310 USA. EM ram.b.jain.ctr@mail.mil NR 44 TC 0 Z9 0 U1 1 U2 6 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1382-6689 EI 1872-7077 J9 ENVIRON TOXICOL PHAR JI Environ. Toxicol. Pharmacol. PD MAR PY 2015 VL 39 IS 2 BP 773 EP 786 DI 10.1016/j.etap.2015.02.002 PG 14 WC Environmental Sciences; Pharmacology & Pharmacy; Toxicology SC Environmental Sciences & Ecology; Pharmacology & Pharmacy; Toxicology GA CH3KP UT WOS:000353929900034 PM 25733129 ER PT J AU Chan, MK Krebs, MO Cox, D Guest, P Yolked, R Rahmoune, H Rothermundt, M Steiner, J Leweke, FM Van Beveren, NJM Niebuhr, DW Webers, NS Cowan, DN Suarez-Pinilla, P Crespo-Facorro, B Mam-Lam-Fook, C Bourgin, J Wenstrup, RJ Kaldate, RR Cooper, JD Bahn, S AF Chan, Man Kuan Krebs, Marie Odile Cox, David Guest, Paul Yolken, Robert Rahmoune, Hassan Rothermundt, Matthias Steiner, Johann Leweke, F. Markus Van Beveren, Nico J. M. Niebuhr, David W. Webers, Natalya S. Cowan, David N. Suarez-Pinilla, Paula Crespo-Facorro, Benedicto Mam-Lam-Fook, Celia Bourgin, Julie Wenstrup, Richard J. Kaldate, Rajesh R. Cooper, Jason D. Bahn, Sabine TI DEVELOPMENT OF A BLOOD-BASED MOLECULAR BIOMARKER TEST FOR IDENTIFICATION OF SCHIZOPHRENIA PRIOR TO DISEASE ONSET SO SCHIZOPHRENIA BULLETIN LA English DT Meeting Abstract CT 15th International Congress on Schizophrenia Research (ICOSR) CY MAR 28-APR 01, 2015 CL Colorado Springs, CO C1 [Chan, Man Kuan; Cox, David; Guest, Paul; Rahmoune, Hassan; Cooper, Jason D.; Bahn, Sabine] Univ Cambridge, Dept Chem Engn & Biotechnol, Cambridge, England. [Krebs, Marie Odile; Mam-Lam-Fook, Celia; Bourgin, Julie] Univ Paris 05, Sorbonne Cite, INSERM, Lab Physiopathol Malad Psychiat, Paris, France. [Yolken, Robert] Johns Hopkins Univ, Sch Med, Baltimore, MD USA. [Rothermundt, Matthias] Univ Munster, D-48149 Munster, Germany. [Steiner, Johann] Univ Magdeburg, Dept Psychiat, D-39106 Magdeburg, Germany. [Leweke, F. Markus] Heidelberg Univ, Cent Inst Mental Hlth, Med Fac Mannheim, Mannheim, Germany. [Van Beveren, Nico J. M.] Erasmus MC, Dept Neurosci, Rotterdam, Netherlands. [Niebuhr, David W.; Webers, Natalya S.; Cowan, David N.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Suarez-Pinilla, Paula; Crespo-Facorro, Benedicto] Univ Cantabria, IDIVAL, CIBERSAM, Univ Hosp Marques Valdecilla, E-39005 Santander, Spain. [Wenstrup, Richard J.; Kaldate, Rajesh R.] Myriad Genet Labs, Salt Lake City, UT USA. [Krebs, Marie Odile; Mam-Lam-Fook, Celia; Bourgin, Julie] Serv Hosp Univ, Hopt St Anne, Ctr Evaluat Jeunes Adultes & Adolescents CJAAD, Fac Med Paris Descartes, Paris, France. [Rothermundt, Matthias] Evangel Klinikum Niederrhein, Oberhausen, Germany. NR 0 TC 0 Z9 0 U1 0 U2 4 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 0586-7614 EI 1745-1701 J9 SCHIZOPHRENIA BULL JI Schizophr. Bull. PD MAR PY 2015 VL 41 SU 1 MA 2085255 BP S13 EP S13 PG 1 WC Psychiatry SC Psychiatry GA CG8HO UT WOS:000353548200034 ER PT J AU Sethi, J Palit, R Carroll, JJ Karamian, S Saha, S Biswas, S Naik, Z Trivedi, T Litz, MS Datta, P Chattopadhyay, S Donthi, R Garg, U Jadhav, S Jain, HC Kumar, S Mehta, D Naidu, BS Bhat, GH Sheikh, JA Sihotra, S Walker, PM AF Sethi, J. Palit, R. Carroll, J. J. Karamian, S. Saha, S. Biswas, S. Naik, Z. Trivedi, T. Litz, M. S. Datta, P. Chattopadhyay, S. Donthi, R. Garg, U. Jadhav, S. Jain, H. C. Kumar, S. Mehta, D. Naidu, B. S. Bhat, G. H. Sheikh, J. A. Sihotra, S. Walker, P. M. TI SPECTROSCOPY OF THE LOW-LYING STATES NEAR THE HIGH SPIN ISOMER IN Ag-108 SO ACTA PHYSICA POLONICA B LA English DT Article; Proceedings Paper CT Zakopane Conference on Nuclear Physics - Extremes of the Nuclear Landscape CY AUG 31-SEP 07, 2014 CL Zakopane, POLAND AB A comprehensive study of the low-lying states of Ag-108, near the isomeric state at E-i = 110 keV with J(pi) = 6(+) and T-1/2 = 438 y, has been presented. Spectroscopy of these states has been carried out using the reaction Mo-100(B-11, 3n gamma)Ag-108 at 39 MeV beam energy using INGA. The multipolarities and electromagnetic nature of the transitions have been assigned based on the angular correlation and polarization measurements. The experimentally identified states have been compared to the results of the Projected Hartree-Fock calculations to understand the configurations involved in these states. C1 [Sethi, J.; Palit, R.; Saha, S.; Biswas, S.; Trivedi, T.; Donthi, R.; Jadhav, S.; Jain, H. C.; Naidu, B. S.] Tata Inst Fundamental Res, Bombay 400005, Maharashtra, India. [Carroll, J. J.; Litz, M. S.] US Army Res Lab, Adelphi, MD 20783 USA. [Karamian, S.] Joint Inst Nucl Res, Dubna 141980, Russia. [Naik, Z.] Sambalpur Univ, Sambalpur 768019, India. [Datta, P.] Ananda Mohan Coll, Kolkata 700009, India. [Chattopadhyay, S.] Saha Inst Nucl Phys, Kolkata 700064, India. [Garg, U.] Univ Notre Dame, Notre Dame, IN 46556 USA. [Kumar, S.] Univ Delhi, Delhi 110007, India. [Mehta, D.; Sihotra, S.] Panjab Univ, Chandigarh 160014, India. [Bhat, G. H.; Sheikh, J. A.] Univ Kashmir, Dept Phys, Srinagar 190006, Jammu & Kashmir, India. [Walker, P. M.] Univ Surrey, Dept Phys, Guildford GU2 7XH, Surrey, England. RP Sethi, J (reprint author), Tata Inst Fundamental Res, Homi Bhabha Rd, Bombay 400005, Maharashtra, India. RI Palit, Rudrajyoti/F-5185-2012 FU Department of Science and Technology, Government of India [IR/S2/PF-03/2003-II] FX The authors would like to thank the members of INGA PICC and INGA Collaboration and the accelerator staff at TIFR-BARC Pelletron-LINAC Facility. This work was partially supported by the Department of Science and Technology, Government of India (Grant No. IR/S2/PF-03/2003-II). NR 10 TC 1 Z9 1 U1 0 U2 1 PU WYDAWNICTWO UNIWERSYTETU JAGIELLONSKIEGO PI KRAKOW PA UL GRODZKA 26, KRAKOW, 31044, POLAND SN 0587-4254 EI 1509-5770 J9 ACTA PHYS POL B JI Acta Phys. Pol. B PD MAR PY 2015 VL 46 IS 3 BP 703 EP 707 DI 10.5506/APhysPolB.46.703 PG 5 WC Physics, Multidisciplinary SC Physics GA CG8NR UT WOS:000353565500054 ER PT J AU Terrill, WA AF Terrill, W. Andrew TI Iran's Strategy for Saving Asad SO MIDDLE EAST JOURNAL LA English DT Article AB For decades, Iran has supported the regime of Bashar al-Asad in Syria with military advisors, weapons, and both diplomatic and financial support due to Tehran's belief that a pro-Iranian government in Syria is a core national interest. In this regard, cooperation with Damascus has provided Tehran with a number of strategic advantages, which it is loath to surrender. More recently, the Iranians have also come to view Syria as a vital ally against the threat of the Islamic State in Iraq and al-Sham (ISIS). In this environment, the Islamic Republic will likely continue to bolster the Asad regime even if the Syrian civil war continues for years. C1 US Army War Coll, Strateg Studies Inst, Carlisle, PA 17013 USA. RP Terrill, WA (reprint author), US Army War Coll, Strateg Studies Inst, Carlisle, PA 17013 USA. NR 81 TC 0 Z9 0 U1 6 U2 16 PU MIDDLE EAST INST PI WASHINGTON PA 1761 N ST NW, CIRCULATION DEPT, WASHINGTON, DC 20036-2882 USA SN 0026-3141 EI 1940-3461 J9 MIDDLE EAST J JI Middle East J. PD SPR PY 2015 VL 69 IS 2 BP 222 EP 236 DI 10.3751/69.2.13 PG 15 WC Area Studies SC Area Studies GA CH1PY UT WOS:000353795000004 ER PT J AU Haight, DJ Esposito, ER Wilken, JM AF Haight, Derek J. Esposito, Elizabeth Russell Wilken, Jason M. TI Biomechanics of uphill walking using custom ankle-foot orthoses of three different stiffnesses SO GAIT & POSTURE LA English DT Article DE Incline; IDEO; Ankle brace; Gait; Limb salvage; Military ID ENERGY-COST; SLOPED SURFACES; STROKE SUBJECTS; GAIT; LOCOMOTION; REHABILITATION; INDIVIDUALS; PERFORMANCE; KINEMATICS; PARAMETERS AB Ankle-foot orthoses (AFOs) can provide support and improve walking ability in individuals with plantarflexor weakness. Passive-dynamic AFO stiffness can be optimized for over-ground walking, however little research exists for uphill walking, when plantarflexor contributions are key. Purpose: Compare uphill walking biomechanics (1) between dynamic AFO users and able-bodied control subjects. (2) between injured and sound limbs (3) across different AFO stiffnesses. Methods: Twelve patients with unilateral limb-salvage and twelve matched, able-bodied controls underwent biomechanical gait analysis when walking up a 10 degrees incline. Three AFO stiffnesses were tested in the patient group: Nominal (clinically prescribed), Compliant (20% less stiff), and Stiff (20% more stiff). Results and discussion: AFO users experienced less ankle motion and power generation, lower knee extensor moments, and greater hip flexion and power generation than controls during uphill walking. Despite these deviations, they walked at equivalent self-selected velocities and stride lengths. Asymmetries were present at the ankle and knee with decreased ankle motion and power, and lower knee extensor moments on the AFO limb. Stiffer AFOs increased knee joint flexion but a 40% range in AFO stiffness had few other effects on gait. Therefore, a wide range of clinically prescribed AFO stiffnesses may adequately assist uphill walking. Published by Elsevier B.V. C1 [Haight, Derek J.; Esposito, Elizabeth Russell; Wilken, Jason M.] Brooke Army Med Ctr, Dept Orthopaed & Rehabil, Ctr Intrepid, Ft Sam Houston, TX 78234 USA. RP Esposito, ER (reprint author), Brooke Army Med Ctr, Dept Orthopaed & Rehabil, Ctr Intrepid, Ft Sam Houston, TX 78234 USA. EM erussell.kin@gmail.com OI Wilken, Jason/0000-0002-5556-7667 FU Center for Rehabilitation Sciences Research Department of Physical Medicine and Rehabilitation, Uniformed Services University of Health Sciences, Bethesda, MD FX The authors acknowledge Nicole Harper and Dr. Richard Neptune at the University of Texas for strut manufacturing and testing. Support was provided by the Center for Rehabilitation Sciences Research Department of Physical Medicine and Rehabilitation, Uniformed Services University of Health Sciences, Bethesda, MD. NR 29 TC 4 Z9 4 U1 2 U2 13 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0966-6362 EI 1879-2219 J9 GAIT POSTURE JI Gait Posture PD MAR PY 2015 VL 41 IS 3 BP 750 EP 756 DI 10.1016/j.gaitpost.2015.01.001 PG 7 WC Neurosciences; Orthopedics; Sport Sciences SC Neurosciences & Neurology; Orthopedics; Sport Sciences GA CG3WB UT WOS:000353209200002 PM 25743775 ER PT J AU Platteborze, P Matos, R Gidvany-Diaz, V Wilhelms, K AF Platteborze, Peter Matos, Renee Gidvany-Diaz, Vinod Wilhelms, Kelly TI An Unexpected Emergency Request for Glucose-6-Phosphate Dehydrogenase Testing in a 9-Year-Old African American Boy SO LABMEDICINE LA English DT Article DE deficiency; glucose-6-phosphate dehydrogenase; leukemia; rasburicase; tumor lysis syndrome; uric acid ID TUMOR LYSIS SYNDROME; METHEMOGLOBINEMIA; RASBURICASE; DEFICIENCY; MANAGEMENT AB Patient: 9-year-old African American male. Chief Complaint: Recently diagnosed with acute lymphoblastic leukemia (ALL) after investigation into a large anterior mediastinal mass causing airway compression. History of Present Illness: The day before the unexpected urgent glucose-6-phosphate dehydrogenase (136PD) request, the patient was diagnosed with an aggressive form of leukemia and a significant tumor mass causing airway compression. A computed tomography (CT) scan indicated potential renal involvement. Based on this information and the size of the mass, the patient was referred for immediate chemotherapy. However, there was a concern that he could develop tumor lysis syndrome (TLS) during treatment. To avoid this condition, the pediatric intensive care unit (ICU) sought to pretreat the child with rasburicase, which led to the emergency G6PD request. Previous Medical History: Unknown. Family History: Largely unknown, but no apparent chronic diseases. Physical Examination Findings: Three weeks of progressively worsening lymphadenopathy, coughing, night sweats, mild hepatosplenomegaly, and breathing difficulty when supine. The patient arrived at the medical center for airway management and had a temperature of 36.1 degrees C; blood pressure, 120/87 mmHg; pulse, 115 bpm; respiratory rate, 22 breaths per minute, with labored breathing but normal O-2 saturation while upright and awake, in room air. Principle Laboratory Findings: Table 1. C1 [Platteborze, Peter; Wilhelms, Kelly] Brooke Army Med Ctr, Dept Pathol & Area Lab Serv, San Antonio, TX 78234 USA. [Matos, Renee; Gidvany-Diaz, Vinod] Brooke Army Med Ctr, Dept Pediat, San Antonio, TX USA. RP Platteborze, P (reprint author), Brooke Army Med Ctr, Dept Pathol & Area Lab Serv, San Antonio, TX 78234 USA. NR 10 TC 0 Z9 0 U1 1 U2 3 PU AMER SOC CLINICAL PATHOLOGY PI CHICAGO PA 2100 W HARRISON ST, CHICAGO, IL 60612 USA SN 0007-5027 EI 1943-7730 J9 LABMEDICINE JI Labmedicine PD SPR PY 2015 VL 46 IS 2 BP 150 EP 152 DI 10.1309/LMEEC680QNEHOGIF PG 3 WC Medical Laboratory Technology SC Medical Laboratory Technology GA CG3MR UT WOS:000353184800010 PM 25918195 ER PT J AU Lyke, J Christodoulou, CG Vera, A Edwards, AH AF Lyke, James Christodoulou, Christos G. Vera, Alonzo Edwards, Art H. TI Special Issue on Reconfigurable Systems: Foundations SO PROCEEDINGS OF THE IEEE LA English DT Editorial Material C1 [Lyke, James] US Air Force, Washington, DC USA. [Lyke, James] AFRL, Space Vehicles Directorate AFRL RV, Kirtland AFB, NM USA. [Lyke, James] AIAA, Washington, DC USA. [Lyke, James] AIAA Comp Syst Tech Comm, Washington, DC USA. [Christodoulou, Christos G.] Univ New Mexico, Dept Elect & Comp Engn, Albuquerque, NM 87131 USA. [Christodoulou, Christos G.] Univ New Mexico, Albuquerque, NM 87131 USA. [Christodoulou, Christos G.] Univ New Mexico, COSMIAC Configurable Space Microsyst Innovat & Ap, Albuquerque, NM 87131 USA. [Edwards, Art H.] Air Force Res Lab, Space Vehicles Directorate, Wright Patterson AFB, OH USA. [Edwards, Art H.] Westinghouse Elect, Cranberry Township, PA USA. [Edwards, Art H.] Univ N Carolina, Charlotte, NC 28223 USA. [Edwards, Art H.] Army Res Lab, Adelphi, MD USA. [Edwards, Art H.] Air Force Res Lab, Wright Patterson AFB, OH USA. RP Lyke, J (reprint author), AFRL Space Elect Branch, Space Vehicles Directorate, Wright Patterson AFB, OH 45433 USA. NR 0 TC 0 Z9 0 U1 1 U2 5 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0018-9219 EI 1558-2256 J9 P IEEE JI Proc. IEEE PD MAR PY 2015 VL 103 IS 3 SI SI BP 287 EP 290 DI 10.1109/JPROC.2015.2399071 PG 4 WC Engineering, Electrical & Electronic SC Engineering GA CG2QH UT WOS:000353119000002 ER PT J AU Lai, WC Ogden, FL Steinke, RC Talbot, CA AF Lai, Wencong Ogden, Fred L. Steinke, Robert C. Talbot, Cary A. TI An efficient and guaranteed stable numerical method for continuous modeling of infiltration and redistribution with a shallow dynamic water table SO WATER RESOURCES RESEARCH LA English DT Article DE infiltration and redistribution; vadose zone modeling; stable and mass conservative ID GREEN-AMPT INFILTRATION; RICHARDS EQUATION; POROUS-MEDIA; SOIL-WATER; FLOW AB We have developed a one-dimensional numerical method to simulate infiltration and redistribution in the presence of a shallow dynamic water table. This method builds upon the Green-Ampt infiltration with Redistribution (GAR) model and incorporates features from the Talbot-Ogden (T-O) infiltration and redistribution method in a discretized moisture content domain. The redistribution scheme is more physically meaningful than the capillary weighted redistribution scheme in the T-O method. Groundwater dynamics are considered in this new method instead of hydrostatic groundwater front. It is also computationally more efficient than the T-O method. Motion of water in the vadose zone due to infiltration, redistribution, and interactions with capillary groundwater are described by ordinary differential equations. Numerical solutions to these equations are computationally less expensive than solutions of the highly nonlinear Richards' (1931) partial differential equation. We present results from numerical tests on 11 soil types using multiple rain pulses with different boundary conditions, with and without a shallow water table and compare against the numerical solution of Richards' equation (RE). Results from the new method are in satisfactory agreement with RE solutions in term of ponding time, deponding time, infiltration rate, and cumulative infiltrated depth. The new method, which we call GARTO can be used as an alternative to the RE for 1-D coupled surface and groundwater models in general situations with homogeneous soils with dynamic water table. The GARTO method represents a significant advance in simulating groundwater surface water interactions because it very closely matches the RE solution while being computationally efficient, with guaranteed mass conservation, and no stability limitations that can affect RE solvers in the case of a near-surface water table. C1 [Lai, Wencong; Ogden, Fred L.; Steinke, Robert C.] Univ Wyoming, Dept Civil & Architectural Engn, Laramie, WY 82071 USA. [Talbot, Cary A.] US Army Corps Engineers Engineer Res & Dev Ctr, Coastal & Hydraul Lab, Vicksburg, MS USA. RP Lai, WC (reprint author), Univ Wyoming, Dept Civil & Architectural Engn, Laramie, WY 82071 USA. EM wlai@uwyo.edu FU US National Science Foundation, EPSCoR program [EPS-1135483]; CI-WATER project FX This research was funded by the US National Science Foundation, EPSCoR program, through cooperative agreement EPS-1135483 to the University of Wyoming and the CI-WATER project. Simulation data and results are available from the authors upon request. The authors thank three anonymous reviewers and two editors for their helpful comments and suggestions. NR 26 TC 3 Z9 3 U1 2 U2 17 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA SN 0043-1397 EI 1944-7973 J9 WATER RESOUR RES JI Water Resour. Res. PD MAR PY 2015 VL 51 IS 3 BP 1514 EP 1528 DI 10.1002/2014WR016487 PG 15 WC Environmental Sciences; Limnology; Water Resources SC Environmental Sciences & Ecology; Marine & Freshwater Biology; Water Resources GA CG3DU UT WOS:000353158800008 ER PT J AU McCoy, JR Mendoza, JM Spik, KW Badger, C Gomez, AF Schmaljohn, CS Sardesai, NY Broderick, KE AF McCoy, Jay R. Mendoza, Janess M. Spik, Kristin W. Badger, Catherine Gomez, Alan F. Schmaljohn, Connie S. Sardesai, Niranjan Y. Broderick, Kate E. TI A multi-head intradermal electroporation device allows for tailored and increased dose DNA vaccine delivery to the skin SO HUMAN VACCINES & IMMUNOTHERAPEUTICS LA English DT Article DE dermal; DNA vaccine; electroporation; multi-agent; noninvasive; tolerable ID IN-VIVO ELECTROPORATION; IMMUNE-RESPONSES; NEUTRALIZING ANTIBODY; NONHUMAN-PRIMATES; CODON USAGE; VIRUS; IMMUNOGENICITY; CHALLENGE; MODEL; IMMUNIZATION AB The identification of an effective and tolerable delivery method is a necessity for the success of DNA vaccines in the clinic. This article describes the development and validation of a multi-headed intradermal electroporation device which would be applicable for delivering multiple DNA vaccine plasmids simultaneously but spatially separated. Reporter gene plasmids expressing green and red fluorescent proteins were used to demonstrate the impact of spatial separation on DNA delivery to increase the number of transfected cells and avoid interference through visible expression patterns. To investigate the impact of plasmid interference on immunogenicity, a disease target was investigated where issues with multi-valent vaccines had been previously described. DNA-based Hantaan and Puumala virus vaccines were delivered separately or as a combination and the effect of multi-valence was determined by appropriate assays. While a negative impact was observed for both antigenic vaccines when delivered together, these effects were mitigated when the vaccine was delivered using the multi-head device. We also demonstrate how the multi-head device facilitates higher dose delivery to the skin resulting in improved immune responses. This new multi-head platform device is an efficient, tolerable and non-invasive method to deliver multiple plasmid DNA constructs simultaneously allowing the tailoring of delivery sites for combination vaccines. Additionally, this device would allow the delivery of multi-plasmid vaccine formulations without risk of impacted immune responses through interference. Such a low-cost, easy to use device platform for the delivery of multi-agent DNA vaccines would have direct applications by the military and healthcare sectors for mass vaccination purposes. C1 [McCoy, Jay R.; Mendoza, Janess M.; Gomez, Alan F.; Sardesai, Niranjan Y.; Broderick, Kate E.] Inovio Pharmaceut Inc, Blue Bell, PA 19462 USA. [Spik, Kristin W.; Badger, Catherine; Schmaljohn, Connie S.] US Army Med Res Inst Infect Dis, Ft Detrick, MD USA. RP Broderick, KE (reprint author), Inovio Pharmaceut Inc, Blue Bell, PA 19462 USA. EM kbroderick@inovio.com RI bebarta, vikhyat/K-3476-2015 FU Department of Defense SBIR [W81XWH-11-C-0051] FX This work was supported in part by a Department of Defense SBIR grant (Phase I and Phase II) number W81XWH-11-C-0051. NR 41 TC 0 Z9 0 U1 2 U2 4 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA SN 2164-5515 EI 2164-554X J9 HUM VACC IMMUNOTHER JI Human Vaccines Immunother. PD MAR PY 2015 VL 11 IS 3 BP 746 EP 754 DI 10.4161/21645515.2014.978223 PG 9 WC Biotechnology & Applied Microbiology; Immunology SC Biotechnology & Applied Microbiology; Immunology GA CF5SA UT WOS:000352616100037 PM 25839221 ER PT J AU Balaban, E Saxena, A Narasimhan, S Roychoudhury, I Koopmans, M Ott, C Goebel, K AF Balaban, Edward Saxena, Abhinav Narasimhan, Sriram Roychoudhury, Indranil Koopmans, Michael Ott, Carl Goebel, Kai TI Prognostic Health-Management System Development for Electromechanical Actuators SO JOURNAL OF AEROSPACE INFORMATION SYSTEMS LA English DT Article ID FLIGHT AB Electromechanical actuators have been gaining increased acceptance as safety-critical actuation devices in the next generation of aircraft and spacecraft. The aerospace manufacturers are not ready, however, to completely embrace electromechanical actuators for all applications due to apprehension with regard to some of the more critical fault modes. This work aims to help address these concerns by developing and testing a prognostic health-management system that diagnoses electromechanical actuator faults and employs prognostic algorithms to track fault progression and predict the actuator's remaining useful life. The diagnostic algorithm is implemented using a combined model-based and data-driven reasoner. The prognostic algorithm, implemented using Gaussian process regression, estimates the remaining life of the faulted component. The paper also covers the selection of fault modes for coverage and methods developed for fault injection. Validation experiments were conducted in both laboratory and flight conditions using a flyable electromechanical actuator test stand. The stand allows test actuators to be subjected to realistic environmental and operating conditions while providing the capability to safely inject and monitor propagation of various fault modes. The paper covers both diagnostic and prognostic run-to-failure experiments, conducted in laboratory and flight conditions for several types of faults. The experiments demonstrated robust fault diagnosis on the selected set of component and sensor faults and high-accuracy predictions of failure time in prognostic scenarios. C1 [Balaban, Edward; Goebel, Kai] NASA, Ames Res Ctr, Intelligent Syst Div, Discovery & Syst Hlth Area, Moffett Field, CA 94035 USA. [Saxena, Abhinav; Roychoudhury, Indranil] NASA, Ames Res Ctr, SGT Inc, Intelligent Syst Div,Discovery & Syst Hlth Area, Moffett Field, CA 94035 USA. [Narasimhan, Sriram] Univ Calif Santa Cruz, NASA, Ames Res Ctr, Intelligent Syst Div,Discovery & Syst Hlth Area, Moffett Field, CA 94035 USA. [Ott, Carl] Tesla Motors, Palo Alto, CA 94035 USA. [Ott, Carl] NASA, Ames Res Ctr, US Army, Aviat Dev Directorate, Moffett Field, CA 94035 USA. RP Balaban, E (reprint author), NASA, Ames Res Ctr, Intelligent Syst Div, Discovery & Syst Hlth Area, MS 269-4, Moffett Field, CA 94035 USA. EM edward.balaban@nasa.gov; abhinav.saxena@nasa.gov; sriram.narasimhan@nasa.gov; indranil.roychoudhury@nasa.gov; michael.t.koopmans@gmail.com; carl.r.ott.mil@mail.mil; kai.goebel@nasa.gov FU NASA FX The funding for this work was provided by the NASA Aviation Safety Program, Integrated Vehicle Health Management and Systemwide Safety Assurance Technologies projects. We would like to thank our colleagues at NASA Ames Research Center for both their help with this research and in preparation of the manuscript. A special thanks goes to Catlin Mattheis and Austin Lawrence, who helped to create the original Flyable electromechanical actuator (FLEA) testbed prototype while at California Polytechnic State University. Steven Braddom, formerly of the U.S. Army Aeroflightdynamics (AFFD) Directorate Flight Projects Office, provided steadfast support for the initial UH-60 flight tests. The flight tests would also not have been possible without the support of AFFD engineers, technicians, and pilots (Casey Blaskowski, Gary Leong, Gary Fayaud, Ellazar Barrientos, Richard Huber, Jay Fletcher, Juan Saucedo, Scott Miller, Ernie Moralez, Munro Dearing, Randall Watson, and Samuel Caires). We also express our gratitude to Steven Fletcher, Bruce Felt, Pete Chaplin, Phillip Jensen, and Minh Wong for their assistance in fabricating the various components of the FLEA. NR 38 TC 5 Z9 7 U1 2 U2 17 PU AMER INST AERONAUTICS ASTRONAUTICS PI RESTON PA 1801 ALEXANDER BELL DRIVE, STE 500, RESTON, VA 22091-4344 USA SN 1940-3151 EI 2327-3097 J9 J AEROSP INFORM SYST JI J. Aerosp. Inf. Syst. PD MAR PY 2015 VL 12 IS 3 BP 329 EP 344 DI 10.2514/1.I010171 PG 16 WC Engineering, Aerospace SC Engineering GA CF8DH UT WOS:000352785300003 ER PT J AU Hermann, LL Gupta, SB Manoff, SB Kalayanarooj, S Gibbons, RV Coller, BAG AF Hermann, Laura L. Gupta, Swati B. Manoff, Susan B. Kalayanarooj, Siripen Gibbons, Robert V. Coller, Beth-Ann G. TI Advances in the understanding, management, and prevention of dengue SO JOURNAL OF CLINICAL VIROLOGY LA English DT Article DE Dengue; Treatment; Diagnosis; Vaccine; Epidemiology ID HEALTHY ADULT VOLUNTEERS; PLACEBO-CONTROLLED TRIAL; ANTIBODY-DEPENDENT ENHANCEMENT; CROSS-REACTIVE ANTIBODIES; TYPE-4 VACCINE CANDIDATE; BLOOD-FEEDING SUCCESS; ENVELOPE DOMAIN III; T-CELL RESPONSES; VIRUS-INFECTION; AEDES-AEGYPTI AB Dengue causes more human morbidity globally than any other vector-borne viral disease. Recent research has led to improved epidemiological methods that predict disease burden and factors involved in transmission, a better understanding of immune responses in infection, and enhanced animal models. In addition, a number of control measures, including preventative vaccines, are in clinical trials. However, significant gaps remain, including the need for better surveillance in large parts of the world, methods to predict which individuals will develop severe disease, and immunologic correlates of protection against dengue illness. During the next decade, dengue will likely expand its geographic reach and become an increasing burden on health resources in affected areas. Licensed vaccines and antiviral agents are needed in order to effectively control dengue and limit disease. (C) 2014 Elsevier B.V. All rights reserved. C1 [Hermann, Laura L.] Univ Toronto, Dept Med, Toronto, ON, Canada. [Hermann, Laura L.; Gibbons, Robert V.] Armed Forces Res Inst Med Sci, Dept Virol, Bangkok 10400, Thailand. [Gupta, Swati B.; Manoff, Susan B.; Coller, Beth-Ann G.] Merck & Co Inc, N Wales, PA 19454 USA. [Kalayanarooj, Siripen] Queen Sirikit Natl Inst Child Hlth, Bangkok, Thailand. RP Coller, BAG (reprint author), Merck & Co Inc, 351 North Sumneytown Pike, N Wales, PA 19454 USA. EM beth-ann.coller@merck.com FU Canadian Institutes of Health Research Fellowship FX Laura Hermann was supported by a Canadian Institutes of Health Research Fellowship. Swati Gupta, Susan Manoff, and Beth-Ann Coller are the Employees of Merck Research Laboratories. NR 138 TC 10 Z9 11 U1 0 U2 13 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1386-6532 EI 1873-5967 J9 J CLIN VIROL JI J. Clin. Virol. PD MAR PY 2015 VL 64 BP 153 EP 159 DI 10.1016/j.jcv.2014.08.031 PG 7 WC Virology SC Virology GA CF0ZP UT WOS:000352273600026 PM 25453329 ER PT J AU Arnold, F DeMallie, I Florence, L Kashinski, DO AF Arnold, F. DeMallie, I. Florence, L. Kashinski, D. O. TI Method for collecting thermocouple data via secured shell over a wireless local area network in real time SO REVIEW OF SCIENTIFIC INSTRUMENTS LA English DT Article AB This manuscript addresses the design, hardware details, construction, and programming of an apparatus allowing an experimenter to monitor and record high-temperature thermocouple measurements of dynamic systems in real time. The apparatus uses wireless network technology to bridge the gap between a dynamic (moving) sample frame and the static laboratory frame. Our design is a custom solution applied to samples that rotate through large angular displacements where hard-wired and typical slip-ring solutions are not practical because of noise considerations. The apparatus consists of a Raspberry PI mini-Linux computer, an Arduino micro-controller, an Ocean Controls thermocouple multiplexer shield, and k-type thermocouples. C1 [Arnold, F.; DeMallie, I.; Florence, L.; Kashinski, D. O.] US Mil Acad, Photon Res Ctr, West Point, NY 10996 USA. RP Arnold, F (reprint author), US Mil Acad, Photon Res Ctr, West Point, NY 10996 USA. EM david.kashinski@usma.edu FU USMA; Army Research Office [ARO 64793-PH]; High Energy Laser Joint Technology Office [HEL-JTO 248-8212] FX D.O.K., L.F., I.D., and F.A. acknowledge support from USMA. D.O.K. and L.F. also acknowledge support from the Army Research Office Grant No. ARO 64793-PH and the High Energy Laser Joint Technology Office Grant No. HEL-JTO 248-8212. NR 10 TC 1 Z9 1 U1 1 U2 17 PU AMER INST PHYSICS PI MELVILLE PA 1305 WALT WHITMAN RD, STE 300, MELVILLE, NY 11747-4501 USA SN 0034-6748 EI 1089-7623 J9 REV SCI INSTRUM JI Rev. Sci. Instrum. PD MAR PY 2015 VL 86 IS 3 AR 035112 DI 10.1063/1.4915490 PG 5 WC Instruments & Instrumentation; Physics, Applied SC Instruments & Instrumentation; Physics GA CE9ZD UT WOS:000352201400077 PM 25832280 ER PT J AU Stewart, JB Pecora, C AF Stewart, Joel B. Pecora, Collin TI Explosively driven air blast in a conical shock tube SO REVIEW OF SCIENTIFIC INSTRUMENTS LA English DT Article AB Explosively driven shock tubes present challenges in terms of safety concerns and expensive upkeep of test facilities but provide more realistic approximations to the air blast resulting from free-field detonations than those provided by gas-driven shock tubes. Likewise, the geometry of conical shock tubes can naturally approximate a sector cut from a spherically symmetric blast, leading to a better agreement with the blast profiles of free-field detonations when compared to those provided by shock tubes employing constant cross sections. The work presented in this article documents the design, fabrication, and testing of an explosively driven conical shock tube whose goal was to closely replicate the blast profile seen from a larger, free-field detonation. By constraining the blast through a finite area, large blasts (which can add significant damage and safety constraints) can be simulated using smaller explosive charges. The experimental data presented herein show that a close approximation to the free-field air blast profile due to a 1.5 lb charge of C4 at 76 in. can be achieved by using a 0.032 lb charge in a 76-in.-long conical shock tube (which translates to an amplification factor of nearly 50). Modeling and simulation tools were used extensively in designing this shock tube to minimize expensive fabrication costs. C1 [Stewart, Joel B.; Pecora, Collin] US Army, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Stewart, JB (reprint author), US Army, Res Lab, Aberdeen Proving Ground, MD 21005 USA. EM joel.b.stewart2.civ@mail.mil; collin.r.pecora.civ@mail.mil OI Stewart, Joel/0000-0002-3059-4917 FU ARL's Survivability and Lethality Analysis Directorate FX Ms. Rachel Ehlers initiated our investigation into explosively driven shock tubes and the authors would like to acknowledge her direction and enthusiasm throughout this program. Dr. Barrie Homan and Dr. Scott Kukuck were solicited for numerous technical discussions throughout the program's planning and execution and their input is greatly appreciated. Dr. Homan also operated the class 4 copper vapor laser, which was used to illuminate some of the experiments detailed in this article. Dr. Andy Anderson and Dr. Ed Kokko of LLNL and Dr. Richard Becker of ARL provided helpful advice concerning the ALE3D calculations. The authors would like to acknowledge Mr. Eric Wilson, the test director for the shock tube experimental program, for his attention to detail and ensuring that the experimental series ran smoothly. Mr. Jason Pierce and Mr. Jason Garvey were instrumental in setting up the diagnostic equipment in the experiments and collecting the data accurately and efficiently. The authors are also grateful to the ARL shops (particularly, Mr. Bobby Hall, Mr. David Weyand, and Mr. Dennis Hash) for fabricating the shock tube and stand, along with the explosive centering devices. Finally, the authors would like to acknowledge Mr. Pat Gillich of ARL's Survivability and Lethality Analysis Directorate for providing overall guidance and financial support and for identifying the critical need to evaluate the blast effects on personnel protective equipment in a controlled manner. NR 9 TC 0 Z9 0 U1 0 U2 5 PU AMER INST PHYSICS PI MELVILLE PA 1305 WALT WHITMAN RD, STE 300, MELVILLE, NY 11747-4501 USA SN 0034-6748 EI 1089-7623 J9 REV SCI INSTRUM JI Rev. Sci. Instrum. PD MAR PY 2015 VL 86 IS 3 AR 035108 DI 10.1063/1.4914898 PG 9 WC Instruments & Instrumentation; Physics, Applied SC Instruments & Instrumentation; Physics GA CE9ZD UT WOS:000352201400073 PM 25832276 ER PT J AU Jiang, HQ Radtke, PJ Weiskittel, AR Coulston, JW Guertin, PJ AF Jiang, Huiquan Radtke, Philip J. Weiskittel, Aaron R. Coulston, John W. Guertin, Patrick J. TI Climate- and soil-based models of site productivity in eastern US tree species SO CANADIAN JOURNAL OF FOREST RESEARCH LA English DT Article DE bootstrap; climate change; climate envelope models; random forest; regression trees; site index ID WESTERN UNITED-STATES; FOREST INVENTORY; INDEX; PINE; PREDICTION; VARIABLES; REGRESSION; SPRUCE; PLANTATIONS; STANDS AB As concerns rise over potential effects of greenhouse gas related climate change on terrestrial ecosystems, forest managers require growth and yield modeling capabilities responsive to changing climate conditions. Our goal was to develop prediction models of site index for eastern US forest tree species with climate and soil properties as predictors for use in predicting potential responses of forest productivity to climate change. Species-specific site index data from the USDA Forest Service Forest Inventory and Analysis (FIA) program were linked to contemporary climate data and soil properties mapped in the USDA Soil Survey Geographic (SSURGO) database. Random forest regression tree based ensemble prediction models of site index were constructed based on 37 climate-related and 15 soil attributes. In addition to a species-specific site index, aggregate models were developed for species grouped into two broad categories: conifer (softwood) and hardwood (broadleaved) species groups. Species-specific models based on climate and soil predictors explained the most variation in site index of any models tested (R-2 = 62.5%, RMSE = 3.2 m). Comparable results were found when grouping species into conifer and hardwood groups (R-2 = 63.9%, RMSE = 4.6 m for conifers; R-2 = 35.9%, RMSE = 4.2 m for hardwoods). Model predictions based on multiple global circulation models (GCMs) and Intergovernmental Panel on Climate Change (IPCC) development scenarios were tested for statistical significance using bootstrap resampling methods. Results showed significant increases over the 21st century in mean site index for conifers between +0.5 and +2.4 m. Over the same time period, mean hardwood site index showed decreases of as much as -1.7 m for the scenarios tested. The results demonstrate the utility of using climate and soils data in predicting site index across a large geographic region, and the potential of climate change to alter forest productivity in the eastern US. Additional investigation is needed to interpret spatial patterns and ecological relationships related to predictions from this type of model. C1 [Jiang, Huiquan; Radtke, Philip J.] Virginia Tech, Forest Resources & Environm Conservat, Blacksburg, VA 24061 USA. [Weiskittel, Aaron R.] Univ Maine, Sch Forest Resources, Orono, ME 04469 USA. [Coulston, John W.] ARS, USDA, Knoxville, TN 37919 USA. [Guertin, Patrick J.] US Army Engn Res & Dev Ctr, Construct Engn Res Lab, Champaign, IL 61826 USA. RP Radtke, PJ (reprint author), Virginia Tech, Forest Resources & Environm Conservat, Blacksburg, VA 24061 USA. EM pradtke@vt.edu OI Radtke, Philip/0000-0002-8921-8406 FU U.S. Department of the Army; Southern Appalachian Mountains (SAM) Cooperative Ecosystem Studies Unit (CESU) FX This research was supported with funding from the U.S. Department of the Army in cooperation with the Southern Appalachian Mountains (SAM) Cooperative Ecosystem Studies Unit (CESU). NR 74 TC 2 Z9 3 U1 4 U2 23 PU CANADIAN SCIENCE PUBLISHING, NRC RESEARCH PRESS PI OTTAWA PA 65 AURIGA DR, SUITE 203, OTTAWA, ON K2E 7W6, CANADA SN 0045-5067 EI 1208-6037 J9 CAN J FOREST RES JI Can. J. For. Res. PD MAR PY 2015 VL 45 IS 3 BP 325 EP 342 DI 10.1139/cjfr-2014-0054 PG 18 WC Forestry SC Forestry GA CF0CX UT WOS:000352211400011 ER PT J AU Meyers, RE Deacon, KS AF Meyers, Ronald E. Deacon, Keith S. TI Space-Time Quantum Imaging SO ENTROPY LA English DT Article ID COHERENCE AB We report on an experimental and theoretical investigation of quantum imaging where the images are stored in both space and time. Ghost images of remote objects are produced with either one or two beams of chaotic laser light generated by a rotating ground glass and two sensors measuring the reference field and bucket field at different space-time points. We further observe that the ghost images translate depending on the time delay between the sensor measurements. The ghost imaging experiments are performed both with and without turbulence. A discussion of the physics of the space-time imaging is presented in terms of quantum nonlocal two-photon analysis to support the experimental results. The theoretical model includes certain phase factors of the rotating ground glass. These experiments demonstrated a means to investigate the time and space aspects of ghost imaging and showed that ghost imaging contains more information per measured photon than was previously recognized where multiple ghost images are stored within the same ghost imaging data sets. This suggests new pathways to explore quantum information stored not only in multi-photon coincidence information but also in time delayed multi-photon interference. The research is applicable to making enhanced space-time quantum images and videos of moving objects where the images are stored in both space and time. C1 [Meyers, Ronald E.; Deacon, Keith S.] US Army Res Lab, Adelphi, MD 20783 USA. RP Meyers, RE (reprint author), US Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM ronald.e.meyers6.civ@mail.mil; keith.s.deacon.civ@mail.mil FU U.S. Army Research Laboratory FX R.E. Meyers and K.S. Deacon thank the U.S. Army Research Laboratory for support. The authors would also like to thank A. Tunick, P. Hemmer, Y. Shih and S. Karmakar for helpful discussions. NR 38 TC 1 Z9 1 U1 4 U2 16 PU MDPI AG PI BASEL PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND SN 1099-4300 J9 ENTROPY-SWITZ JI Entropy PD MAR PY 2015 VL 17 IS 3 BP 1508 EP 1534 DI 10.3390/e17031508 PG 27 WC Physics, Multidisciplinary SC Physics GA CF5QR UT WOS:000352612500037 ER PT J AU Hampton, SE Moore, MV Ozersky, T Stanley, EH Polashenski, CM Galloway, AWE AF Hampton, Stephanie E. Moore, Marianne V. Ozersky, Tedy Stanley, Emily H. Polashenski, Christopher M. Galloway, Aaron W. E. TI Heating up a cold subject: prospects for under-ice plankton research in lakes SO JOURNAL OF PLANKTON RESEARCH LA English DT Article DE winter; ice; plankton; trophic interactions; nutritional quality; state transitions ID ARCTIC SEA-ICE; FRESH-WATER LAKES; CLIMATE-CHANGE; AULACOSEIRA-BAICALENSIS; TROPHIC DYNAMICS; FATTY-ACIDS; SNOW COVER; PEG-MODEL; BAIKAL; PHYTOPLANKTON AB Long-term patterns and drivers of ecosystem structure may be misunderstood if knowledge of an ecosystem is derived primarily from a single season, a situation common in many temperate lakes where the role of winter has been less studied. In lakes, avoidance of winter research has been especially pronounced for those that experience winter ice, but critical ecological processes can take place under ice. Even when obscured by snow, ice transmitting as little as 2% incident light can allow relatively high rates of photosynthesis, and winter trophic interactions may have year-round repercussions. Here, we offer a suite of research questions that require attention, in order to build a mature understanding of seasonal plankton dynamics in lakes. Specifically, we ask freshwater ecologists to consider the extent to which abundance and nutrition of winter primary productivity supports consumers under the ice, reorganizes food webs, and how long the effects of winter trophic dynamics extend throughout the year. In addition, we recognize some critical gaps in knowledge about physical and biogeochemical conditions at the time of ice-off. Worldwide shortening in ice duration lends imperative to under-ice studies, in order to more fully understand changes in ecosystem structure and function that may already be underway. C1 [Hampton, Stephanie E.; Galloway, Aaron W. E.] Washington State Univ, Ctr Environm Res Educ & Outreach, Pullman, WA 99164 USA. [Moore, Marianne V.] Wellesley Coll, Dept Biol Sci, Wellesley, MA 02481 USA. [Ozersky, Tedy] Univ Minnesota, Large Lakes Observ, Duluth, MN 55812 USA. [Stanley, Emily H.] Univ Wisconsin, Dept Zool, Madison, WI 53706 USA. [Stanley, Emily H.] Univ Wisconsin, Ctr Limnol, Madison, WI 53706 USA. [Polashenski, Christopher M.] US Army, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. RP Hampton, SE (reprint author), Washington State Univ, Ctr Environm Res Educ & Outreach, Pullman, WA 99164 USA. EM s.hampton@wsu.edu OI Hampton, Stephanie/0000-0003-2389-4249 FU National Science Foundation (NSF DEB) [1431428, 1136637]; Washington State University FX Funding was provided by the National Science Foundation (NSF DEB #1431428; NSF DEB #1136637) and Washington State University. NR 66 TC 13 Z9 13 U1 4 U2 33 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 0142-7873 EI 1464-3774 J9 J PLANKTON RES JI J. Plankton Res. PD MAR-APR PY 2015 VL 37 IS 2 BP 277 EP 284 DI 10.1093/plankt/fbv002 PG 8 WC Marine & Freshwater Biology; Oceanography SC Marine & Freshwater Biology; Oceanography GA CF3ZK UT WOS:000352487600001 ER PT J AU Memisevic, V Zavaljevski, N Rajagopala, SV Kwon, K Pieper, R DeShazer, D Reifman, J Wallqvist, A AF Memisevic, Vesna Zavaljevski, Nela Rajagopala, Seesandra V. Kwon, Keehwan Pieper, Rembert DeShazer, David Reifman, Jaques Wallqvist, Anders TI Mining Host-Pathogen Protein Interactions to Characterize Burkholderia mallei Infectivity Mechanisms SO PLOS COMPUTATIONAL BIOLOGY LA English DT Article ID NETWORK ALIGNMENT; MOONLIGHTING PROTEINS; BACTERIAL VIRULENCE; GLOBAL ALIGNMENT; IN-VIVO; PSEUDOMALLEI; SECRETION; STRATEGIES; BIOCONDUCTOR; MELIOIDOSIS AB Burkholderia pathogenicity relies on protein virulence factors to control and promote bacterial internalization, survival, and replication within eukaryotic host cells. We recently used yeast two-hybrid (Y2H) screening to identify a small set of novel Burkholderia proteins that were shown to attenuate disease progression in an aerosol infection animal model using the virulent Burkholderia mallei ATCC 23344 strain. Here, we performed an extended analysis of primarily nine B. mallei virulence factors and their interactions with human proteins to map out how the bacteria can influence and alter host processes and pathways. Specifically, we employed topological analyses to assess the connectivity patterns of targeted host proteins, identify modules of pathogen-interacting host proteins linked to processes promoting infectivity, and evaluate the effect of crosstalk among the identified host protein modules. Overall, our analysis showed that the targeted host proteins generally had a large number of interacting partners and interacted with other host proteins that were also targeted by B. mallei proteins. We also introduced a novel Host-Pathogen Interaction Alignment (HPIA) algorithm and used it to explore similarities between host-pathogen interactions of B. mallei, Yersinia pestis, and Salmonella enterica. We inferred putative roles of B. mallei proteins based on the roles of their aligned Y. pestis and S. enterica partners and showed that up to 73% of the predicted roles matched existing annotations. A key insight into Burkholderia pathogenicity derived from these analyses of Y2H host-pathogen interactions is the identification of eukaryotic-specific targeted cellular mechanisms, including the ubiquitination degradation system and the use of the focal adhesion pathway as a fulcrum for transmitting mechanical forces and regulatory signals. This provides the mechanisms to modulate and adapt the host-cell environment for the successful establishment of host infections and intracellular spread. C1 [Memisevic, Vesna; Zavaljevski, Nela; Reifman, Jaques; Wallqvist, Anders] US Army Med Res & Mat Command, Dept Def, Biotechnol High Performance Comp Software Applica, Telemed & Adv Technol Res Ctr, Ft Detrick, MD 21702 USA. [Rajagopala, Seesandra V.; Kwon, Keehwan; Pieper, Rembert] J Craig Venter Inst, Rockville, MD USA. [DeShazer, David] US Army Med Res Inst Infect Dis, Bacteriol Div, Ft Detrick, MD USA. RP Memisevic, V (reprint author), US Army Med Res & Mat Command, Dept Def, Biotechnol High Performance Comp Software Applica, Telemed & Adv Technol Res Ctr, Ft Detrick, MD 21702 USA. EM jaques.reifman.civ@mail.mil OI wallqvist, anders/0000-0002-9775-7469; Rajagopala, Seesandra/0000-0001-7176-5770 FU U.S. Defense Threat Reduction Agency [CBS.MEDBIO.02.10.BH.021]; U.S. Army Medical Research and Materiel Command as part of the U.S. Army's Network Science Initiative FX This work was supported by the U.S. Defense Threat Reduction Agency(www.dtra.mil; award number CBS.MEDBIO.02.10.BH.021) and by the U.S. Army Medical Research and Materiel Command (mrmc.amedd.army.mil) as part of the U.S. Army's Network Science Initiative. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 65 TC 5 Z9 5 U1 4 U2 12 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1553-734X EI 1553-7358 J9 PLOS COMPUT BIOL JI PLoS Comput. Biol. PD MAR PY 2015 VL 11 IS 3 AR UNSP e1004088 DI 10.1371/journal.pcbi.1004088 PG 28 WC Biochemical Research Methods; Mathematical & Computational Biology SC Biochemistry & Molecular Biology; Mathematical & Computational Biology GA CE9XB UT WOS:000352195700014 PM 25738731 ER PT J AU Adler, AB Williams, J McGurk, D Moss, A Bliese, PD AF Adler, Amy B. Williams, Jason McGurk, Dennis Moss, Andrew Bliese, Paul D. TI Resilience Training with Soldiers during Basic Combat Training: Randomisation by Platoon SO APPLIED PSYCHOLOGY-HEALTH AND WELL BEING LA English DT Article DE Basic Combat Training; group randomised trial; resilience ID PSYCHOLOGICAL ADJUSTMENT; DEPRESSIVE SYMPTOMS; IRAQ RANDOMIZATION; NAVY RECRUITS; INTERVENTIONS; PERCEPTIONS; ADAPTATION; VALIDATION; PREVENTION; MILITARY AB Background: Resilience Training has the potential to mitigate mental health symptoms when provided during initial military training. Methods: The present study examined the impact of Resilience Training on US soldier well-being and attitudes during Basic Combat Training. Platoons were randomly assigned to Resilience Training or Military History provided during the first few days of Basic Combat Training. Surveys were conducted at baseline, post-intervention, and 3, 6, and 9 weeks. Results: The sample resulted in a total of 1,939 soldiers who completed at least the baseline and one follow-up survey. There were no significant differences between conditions in terms of depression symptoms, anxiety symptoms, or sleep problems. However, while anxiety decreased in both conditions, the rate of decrease was faster in the Resilience Training condition. In contrast, Resilience Training had a slower rate of increase in group cohesion over time than the Military History condition. In addition, Resilience Training was associated with greater confidence in helping others and received more positive ratings than Military History. Conclusions: Findings demonstrate that the brief Resilience Training studied here may have some utility in supporting mental health and peer support but may not benefit unit climate. C1 [Adler, Amy B.] US Army Med Res Unit Europe, Sembach, Germany. [Williams, Jason] Res Triangle Inst, Res Triangle Pk, NC USA. [McGurk, Dennis] Mil Operat Med Res Program, Med Res & Mat Command, Frederick, MD USA. [Moss, Andrew] Australian Army, Mental Hlth & Psychol, Canberra, ACT, Australia. [Bliese, Paul D.] Walter Reed Army Inst Res, Silver Spring, MD USA. RP Adler, AB (reprint author), Ctr Mil Psychiat & Neurosci, Walter Reed Army Inst Res, Mil Psychiat Branch, Silver Spring, MD 20910 USA. EM amy.b.adler.civ@mail.mil FU Research Triangle Institute (RTI) FX We thank Michael Wood, Michael Rinehart, Michael Hagan, Tracy Johnson, Victor Martinez, Rachel Eckford, Angela Salvi, Steven Terry, Julie Merrill, Louis Csoka, Tom Powers, Sonya Cable, Stephanie Muraca, and the Research Triangle Institute (RTI) for their research support in the US and David Morton, Stephanie Hodson, and Andrew Cohn for their research support in the Australian Defence Force. The views expressed in this article are those of the authors and do not necessarily represent the official policy or position of the US Army Medical Command or the Australian Defence Force. NR 44 TC 2 Z9 3 U1 4 U2 12 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1758-0846 EI 1758-0854 J9 APPL PSYCHOL-HLTH WE JI Appl. Psychol.-Health Well Being PD MAR PY 2015 VL 7 IS 1 BP 85 EP 107 DI 10.1111/aphw.12040 PG 23 WC Psychology, Applied SC Psychology GA CE5AC UT WOS:000351841000006 PM 25641899 ER PT J AU Attatippaholkun, W Pankhong, P Nisalak, A Kalayanarooj, S AF Attatippaholkun, Watcharee Pankhong, Panyupa Nisalak, Ananda Kalayanarooj, Smpen TI Evolutionary relationship of 5 '-untranslated regions among Thai dengue-3 viruses, Bangkok isolates, during 24 year-evolution SO ASIAN PACIFIC JOURNAL OF TROPICAL MEDICINE LA English DT Article DE Thai dengue-3 viruses; Evolutionary relationship; 5 ' untranslated regions; 24 Year-evolution ID RNA SECONDARY STRUCTURES; VIRAL REPLICATION; CODING REGION; GENOME; PREDICTION; INFECTION; SEQUENCES; ELEMENTS AB Objective: To study evolutionary relationship of the 5'untranslated regions (5'UTRs) in low passage dengue3 viruses (DEN3) isolated from hospitalized children with different clinical manifestations in Bangkok during 24 year-evolution (1977-2000) comparing to the DEN3 prototype (H87). Methods: The 5'UTRs of these Thai DEN3 and the H87 prototype were amplified by RT-PCR and sequenced. Their multiple sequence alignments were done by Codon Code Aligner v 4.0.4 software and their RNA secondary structures were predicted by MFOLD software. Replication of five Thai DEN3 candidates comparing to the H87 prototype were done in human (HepG2) and the mosquito (C6/36) cell lines. Results: Among these Thai DEN3, the completely identical sequences of their first 89 nucleotides, their high-order secondary structure of 5'UTRs and three SNPs including the predominant C90T, and two minor SNPs including A109G and A112G were found. The C90T of Thai DEN3, Bangkok isolates was shown predominantly before 1977. Five Thai DEN3 candidates with the predominant C90T were shown to replicate in human (HepG2) and the mosquito (C6/36) cell lines better than the H87 prototype. However, their highly conserved sequences as well as SNPs of the 5'UTR did not appear to correlate with their disease severity in human. Conclusions: Our findings highlighted evolutionary relationship of the completely identical 89 nucleotide sequence. the high-order secondary structure and the predominant C90T of the 5'UTR of these Thai DEN3 during 24 year-evolution further suggesting to be their genetic markers and magic targets for future research on antiviral therapy as well as vaccine approaches of Thai DEN3. C1 [Attatippaholkun, Watcharee; Pankhong, Panyupa] Mahidol Univ, Fac Med Technol, Dept Clin Chem, Bangkok 10700, Thailand. [Nisalak, Ananda] US Army Med Component, Armed Forces Res Inst Med Sci, Dept Virol, Bangkok 10400, Thailand. [Kalayanarooj, Smpen] Queen Sirikit Natl Inst Child Hlth, Bangkok 10400, Thailand. RP Attatippaholkun, W (reprint author), Mahidol Univ, Fac Med Technol, Dept Clin Chem, Bangkok 10700, Thailand. EM mtwap@mahidol.ac.th FU Program in Science and Technology Cooperation [493-5600-G-00-3461] FX This work was supported by two research grants of Associate Professor Dr. W. Attatippaholkun: Grant No.493-5600-G-00-3461, Program in Science and Technology Cooperation. Human Capacity Development, Bureau for Global Programs. Field Support and Research, US Agency for International Development. Washington, DC and The Royal Golden Jubilee-Ph.D Program, Thailand Research Fund, Thailand. The authors would like to thank Dr. Bruce L. Innis, Dr. David W.Vaughn, Dr. Mammen P. Mammen, Jr. and Dr. Timothy P. Endy for kindly providing all these Thai DEN3 isolates studied in this project, which were maintained at Department of Virology, The US Army Medical Component, Armed Forces Research Institute of Medical Sciences (USAMC-AFRIMS), Bangkok, Thailand. Cell culture analysis was supported by Professor Dr. David B. Weiner's laboratory, University of Pennsylvania. Philadelphia, PA. NR 34 TC 0 Z9 0 U1 0 U2 3 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1995-7645 J9 ASIAN PAC J TROP MED JI Asian Pac. J. Trop. Med. PD MAR PY 2015 VL 8 IS 3 BP 176 EP 184 DI 10.1016/S1995-7645(14)60311-4 PG 9 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA CE5QW UT WOS:000351891700002 PM 25902157 ER PT J AU Strandenes, G Hervig, TA Bjerkvig, CK Williams, S Eliassen, HS Fosse, TK Torvanger, H Cap, AP AF Strandenes, Geir Hervig, Tor A. Bjerkvig, Christopher K. Williams, Steve Eliassen, Hakon S. Fosse, Theodor K. Torvanger, Hans Cap, Andrew P. TI The Lost Art of Whole Blood Transfusion in Austere Environments SO CURRENT SPORTS MEDICINE REPORTS LA English DT Review ID IRREVERSIBLE HEMORRHAGIC SHOCK; DAMAGE CONTROL RESUSCITATION; TRAUMA PATIENTS; IMPROVED SURVIVAL; OXYGEN DEFICIT; REQUIREMENT; MORTALITY; PLATELETS; PRESSURE; PLASMA AB The optimal resuscitation fluid for uncontrolled bleeding and hemorrhagic shock in both pre- and in-hospital settings has been an ongoing controversy for decades. Hemorrhage continues to be a major cause of death in both the civilian and military trauma population, and survival depends on adequacy of hemorrhage control and resuscitation between onset of bleeding and arrival at a medical treatment facility. The terms far-forward and austere are defined, respectively, as the environment where professional health care providers normally do not operate and a setting in which basic equipment and capabilities necessary for resuscitation are often not available. The relative austerity of a treatment setting may be a function of timing rather than just location, as life-saving interventions must be performed quickly before hemorrhagic shock becomes irreversible. Fresh whole blood transfusions in the field may be a feasible life-saving procedure when facing significant hemorrhage. C1 [Strandenes, Geir] Norwegian Naval Special Operat Commando, Bergen, Norway. [Strandenes, Geir; Hervig, Tor A.; Eliassen, Hakon S.] Haukeland Hosp, Dept Immunol & Transfus Med, N-5021 Bergen, Norway. [Bjerkvig, Christopher K.; Fosse, Theodor K.; Torvanger, Hans] Haukeland Hosp, Dept Anesthesia & Intens Care, N-5021 Bergen, Norway. [Williams, Steve] Med Operat Royal Caribbean Cruises Ltd, Miami, FL USA. [Cap, Andrew P.] US Army, Inst Surg Res, Joint Base San Antonio F, TX USA. RP Strandenes, G (reprint author), Haukeland Hosp, Dept Immunol & Transfus Med, N-5021 Bergen, Norway. EM geir@docfish.no NR 29 TC 1 Z9 1 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1537-890X EI 1537-8918 J9 CURR SPORT MED REP JI Curr. Sport. Med. Rep. PD MAR-APR PY 2015 VL 14 IS 2 BP 129 EP 134 DI 10.1249/JSR.0000000000000130 PG 6 WC Sport Sciences SC Sport Sciences GA CE2BS UT WOS:000351618400014 PM 25757009 ER PT J AU Bar-Cohen, A Matin, K Jankowski, N Sharar, D AF Bar-Cohen, Avram Matin, Kaiser Jankowski, Nicholas Sharar, Darin TI Two-Phase Thermal Ground Planes: Technology Development and Parametric Results SO JOURNAL OF ELECTRONIC PACKAGING LA English DT Article ID HIGH-HEAT-FLUX AB Defense Advanced Research Project Agency's (DARPA's) thermal ground plane (TGP) effort was aimed at combining the advantages of vapor chambers or two-dimensional (2D) heat pipes and solid conductors by building thin, high effective thermal conductivity, flat heat pipes out of materials with thermal expansion coefficients that match current electronic devices. In addition to the temperature uniformity and minimal load-driven temperature variations associated with such two phase systems, in their defined parametric space, flat heat pipes are particularly attractive for Department of Defense and commercial systems because they offer a passive, reliable, light-weight, and low-cost path for transferring heat away from high power dissipative components. However, the difference in thermal expansion coefficients between silicon or ceramic microelectronic components and metallic vapor chambers, as well as the need for a planar, chip-size attachment surface for these devices, has limited the use of commercial of the shelf flat heat pipes in this role. The primary TGP goal was to achieve extreme lateral thermal conductivity, in the range of 10 kW/mK-20 kW/mK or approximately 25-50 times higher than copper and 10 times higher than synthetic diamond, with a thickness of 1 mm or less. C1 [Bar-Cohen, Avram] DARPA, MTO, Arlington, VA 22203 USA. [Matin, Kaiser] Syst Planning Corp, Arlington, VA 22201 USA. [Jankowski, Nicholas] US Army Res Lab, Adelphi, MD 20783 USA. [Sharar, Darin] Gen Tech Serv LLC, Wall Township, NJ 07719 USA. RP Bar-Cohen, A (reprint author), DARPA, MTO, 675 North Randolph St, Arlington, VA 22203 USA. EM abc@darpa.mil; kaiser.matin.ctr@darpa.mil; Nicholas.Jankowski@us.army.mil; darin.j.sharar.ctr@mail.mil FU DARPA's TGP program [BAA 7-36] FX The authors want to acknowledge Dr. Thomas Kenny (former PM/MTO) for his efforts in defining, initiating and guiding the early stages of DARPA's TGP program, under BAA 7-36. We also want to thank Dr. Kristen Bloschock currently at Lockheed Martin Corporation and the principal investigators of the DARPA TGP program: Q. Cai from Teledyne, Scott Miller from GE, David Altmen from Raytheon, Larry Greenberg from NG, Y. Sungtaek Ju from UCLA, Albert Pisano from UC-Berkeley, Carl Meinhart from UCSB, and Y. C. Lee from the University of Colorado-Boulder, for their contributions to this paper. NR 29 TC 5 Z9 5 U1 2 U2 9 PU ASME PI NEW YORK PA TWO PARK AVE, NEW YORK, NY 10016-5990 USA SN 1043-7398 EI 1528-9044 J9 J ELECTRON PACKAGING JI J. Electron. Packag. PD MAR PY 2015 VL 137 IS 1 AR 010801 DI 10.1115/1.4028890 PG 9 WC Engineering, Electrical & Electronic; Engineering, Mechanical SC Engineering GA CE2JR UT WOS:000351642400001 ER PT J AU Ernst, M Habtour, E Dasgupta, A Pohland, M Robeson, M Paulus, M AF Ernst, Matthew Habtour, Ed Dasgupta, Abhijit Pohland, Michael Robeson, Mark Paulus, Mark TI Comparison of Electronic Component Durability Under Uniaxial and Multiaxial Random Vibrations SO JOURNAL OF ELECTRONIC PACKAGING LA English DT Article DE multiaxial; nonlinear; vibration; fatigue; simultaneous loading AB Multiaxial and uniaxial vibration experiments were conducted in order to study the differences in failure modes and fatigue life for the two types of excitation. An electrodynamic (ED) shaker capable of controlled vibration in six degrees of freedom (DOF) was employed for the experiments. The test specimen consisted of six large inductors insertion mounted on a printed wiring board (PWB). Average damage accumulation rate (DAR) in the inductor leads was measured for random excitations in-plane, out-of-plane, and both directions simultaneously. Under simultaneous multiaxial excitation, the average DAR was found to be 2.2 times greater than the sum of the in-plane and out-of-plane DARs. The conclusion was that multiple-step sequential uniaxial testing may significantly overestimate the durability of large/heavy structures with high center of mass in a multiaxial dynamic environment. Additionally, a test method utilizing uniaxial vibration along a direction other than the principal directions of the structure was examined. This method was found to have significant limitations, but showed better agreement with simultaneous multiaxial vibration experiments. C1 [Ernst, Matthew] Johns Hopkins Univ, Appl Phys Lab, Laurel, MD 20723 USA. [Habtour, Ed] US Army Res Lab, Vehicle Technol Directorate, Aberdeen Proving Ground, MD 21005 USA. [Dasgupta, Abhijit] Univ Maryland, Ctr Adv Life Cycle Engn, College Pk, MD 20742 USA. [Pohland, Michael] US Army Mat Syst Act Anal, Aberdeen Proving Ground, MD 21005 USA. [Robeson, Mark] US Armys Aviat Dev Directorate Ft Eustis, Ft Eustis, VA 23604 USA. [Paulus, Mark] Naval Undersea Warfare Ctr, Keyport, WA 98345 USA. RP Ernst, M (reprint author), Johns Hopkins Univ, Appl Phys Lab, Johns Hopkins Rd, Laurel, MD 20723 USA. EM ernstm@gmail.com; ed.m.habtour.civ@mail.mil; dasgupta@umd.edu; michael.f.pohland.civ@mail.mil; mark.e.robeson.civ@mail.mil; mark.paulus@navy.mil OI Habtour, Ed/0000-0002-9083-9285 FU Center for Advanced Life Cycle Engineering (CALCE) at the University of Maryland; U.S. Army Research Laboratory; University of Maryland, College Park, MD; Naval Undersea Warfare Center FX This research effort was funded by the sponsors of the Center for Advanced Life Cycle Engineering (CALCE) at the University of Maryland and was further supported by a Collaborative Research and Development Agreement (CRADA) between the U.S. Army Research Laboratory and the University of Maryland, College Park, MD. We gratefully acknowledge the continual support of Naval Undersea Warfare Center and for the unique MDOF test setup provided by TEAM Inc. and Data Physics Inc. NR 19 TC 4 Z9 4 U1 0 U2 14 PU ASME PI NEW YORK PA TWO PARK AVE, NEW YORK, NY 10016-5990 USA SN 1043-7398 EI 1528-9044 J9 J ELECTRON PACKAGING JI J. Electron. Packag. PD MAR PY 2015 VL 137 IS 1 AR 011009 DI 10.1115/1.4028516 PG 8 WC Engineering, Electrical & Electronic; Engineering, Mechanical SC Engineering GA CE2JR UT WOS:000351642400010 ER PT J AU Fresconi, F DeSpirito, J Celmins, I AF Fresconi, Frank DeSpirito, James Celmins, Ilmars TI Flight Performance of a Small Diameter Munition with a Rotating Wing Actuator SO JOURNAL OF SPACECRAFT AND ROCKETS LA English DT Article ID NAVIER-STOKES PREDICTIONS; CONTROLLED PROJECTILES; JET INTERACTION; STABILITY; GUIDANCE AB Future enhanced lethal effects at the infantry squad level likely include precision guided technologies. The focus of this study is maneuvering projectiles launched from man-portable weapon systems. Anovel guided projectile concept is proposed for achieving control authority requirements in the challenging environment of low-dynamic pressure, small size, high launch loads, spin stabilization, and low cost. This new maneuver concept is based on a rotating wing actuator. Experimental and advanced computational aerodynamics techniques were applied. Aerodynamic models and projectile flight mechanics were derived to enable flight simulation. Assessment of ballistic delivery accuracy, based on physics-based models of the delivery process, was undertaken to quantify control authority requirements. Maneuvering flight simulations demonstrated that this concept affords enough course correction to compensate for ballistic delivery errors. C1 [Fresconi, Frank] US Army Res Lab, Weap & Mat Res Directorate, Precis & Guided Flight Dynam, RDRL WML E, Aberdeen Proving Ground, MD 21005 USA. [DeSpirito, James; Celmins, Ilmars] US Army Res Lab, Weap & Mat Res Directorate, RDRL WML E, Aberdeen Proving Ground, MD 21005 USA. RP Fresconi, F (reprint author), US Army Res Lab, Weap & Mat Res Directorate, Precis & Guided Flight Dynam, RDRL WML E, Aberdeen Proving Ground, MD 21005 USA. FU U.S. Department of Defense (DoD) FX The authors are grateful to the scientists, engineers, and technicians from the Edgewood Chemical and Biological Center at the Aberdeen Proving Ground for conducting wind-tunnel experiments. This work was performed in part by a grant of high-performance computing time from the U.S. Department of Defense (DoD) High Performance Computing Modernization Program Supercompting Resource Centers at the U.S. Air Force Research Laboratory, Wright-Paterson Air Force Base, OH; the U.S. Army Research Laboratory, Aberdeen Proving Ground, MD; and the U.S. Army Engineer Research and Development Center, Vicksburg, MS. NR 36 TC 0 Z9 0 U1 1 U2 4 PU AMER INST AERONAUTICS ASTRONAUTICS PI RESTON PA 1801 ALEXANDER BELL DRIVE, STE 500, RESTON, VA 22091-4344 USA SN 0022-4650 EI 1533-6794 J9 J SPACECRAFT ROCKETS JI J. Spacecr. Rockets PD MAR PY 2015 VL 52 IS 2 BP 305 EP 319 DI 10.2514/1.A32931 PG 15 WC Engineering, Aerospace SC Engineering GA CE2CS UT WOS:000351621400001 ER PT J AU Frank, RM Parada, SA Mascarenhas, R Romeo, AA AF Frank, Rachel M. Parada, Stephen A. Mascarenhas, Randy Romeo, Anthony A. TI When Allografts Fail for Instability Surgery-What to Do? SO OPERATIVE TECHNIQUES IN SPORTS MEDICINE LA English DT Article DE shoulder instability; allograft; revision stabilization; bone augmentation ID HILL-SACHS LESION; GLENOID BONE LOSS; ANTERIOR GLENOHUMERAL INSTABILITY; PERIPROSTHETIC JOINT INFECTIONS; OSTEOCHONDRAL ALLOGRAFTS; OSTEOARTICULAR ALLOGRAFT; SHOULDER ARTHROPLASTY; FOLLOW-UP; RECONSTRUCTION; MANAGEMENT AB The glenohumeral joint is a highly congruous articulation that is dependent on the osseous integrity of both the glenoid rim and the humeral head. Disruptions in the bony architecture of either surface occur in up to 100% of shoulders in the setting of recurrent anterior shoulder instability. Unrecognized, as well as underappreciated, glenoid bone loss in the setting of glenohumeral instability is especially problematic. As bone loss approaches 20% or more of the glenoid surface area, surgical strategies tend to incorporate a bony reconstruction, with either an autograft or an allograft. Similarly, bone defects of greater than 25%-30% of the humeral head tend to warrant surgical treatment; although often in this setting, reconstruction of the glenoid restores smooth articulation with the humeral head, despite the defect, and no further treatment is required. Although short-term outcomes following allograft reconstruction of the glenohumeral joint are encouraging, given the relatively few medium- and long-term reports available, it is difficult to draw conclusions as to how these procedures fare over time. Cases of recurrent instability despite appropriate allograft reconstruction exist, and surgical options are typically salvage-type procedures, limited to revision allograft reconstruction or arthroplasty. This review focuses on the indications for allograft reconstruction of the glenohumeral joint, definition of and workup of patients experiencing recurrent instability following allograft augmentation, and treatment options for these difficult patients. A treatment algorithm summarizing the authors recommended management of these patients has also been provided. (C) 2015 Elsevier Inc. All rights reserved. C1 [Frank, Rachel M.; Mascarenhas, Randy; Romeo, Anthony A.] Rush Univ, Med Ctr, Dept Orthopaed Surg, Chicago, IL 60612 USA. [Parada, Stephen A.] Uniformed Serv Univ Hlth Sci, Eisenhower Army Med Ctr, Dept Orthopaed, Ft Gordon, GA USA. RP Frank, RM (reprint author), Rush Univ, Med Ctr, Dept Orthopaed Surg, 1611 W Harrison St Suite 200, Chicago, IL 60612 USA. EM rmfrank3@gmail.com OI Romeo, Anthony/0000-0003-4848-3411 NR 48 TC 0 Z9 0 U1 1 U2 1 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 1060-1872 EI 1557-9794 J9 OPER TECHN SPORT MED JI Oper. Tech. Sports Med. PD MAR PY 2015 VL 23 IS 1 BP 43 EP 51 DI 10.1053/j.otsm.2014.10.002 PG 9 WC Sport Sciences; Surgery SC Sport Sciences; Surgery GA CE4FN UT WOS:000351786600007 ER PT J AU DeRosa, R Lustik, MB Stackhouse, DA McMann, LP AF DeRosa, Raffaella Lustik, Michael B. Stackhouse, Danielle A. McMann, Leah P. TI Impact of the 2012 American Urological Association Vasectomy Guidelines on Postvasectomy Outcomes in a Military Population SO UROLOGY LA English DT Article ID SEMEN ANALYSIS; SPERM; CANCER; NUMBER; RATES; TIME; MEN AB OBJECTIVE To evaluate the impact of the 2012 American Urological Association vasectomy guidelines on postvasectomy clinical outcomes in a highly mobile military cohort and compare these outcomes with those of civilian counterparts. METHODS The records of service members who underwent vasectomy between January 2008 and December 2013 and provided at least 1 postvasectomy semen analysis (PVSA) were analyzed in the context of the 2012 guidelines. Time to occlusive success, repeat PVSAs and vasectomies, and health care cost savings were compared between our prior definition of vasectomy success, which required azoospermia, and the 2012 criteria, which included rare nonmotile sperm. RESULTS Of the 1623 men who underwent vasectomy, 738 men (45%) failed to submit a PVSA, leaving 895 men (55%) who provided at least 1 PVSA. A total of 1084 PVSAs were obtained in these men, who had a mean age of 37 +/- 6 years. Defining success as azoospermia on first PVSA resulted in a sterility rate of 69%. After application of the 2012 guidelines, 845 patients (94%) achieved sterility by the first PVSA and more patients achieved sterility 60 days from vasectomy (96% vs 72%; P < .001). Inclusion of rare nonmotile sperm in our definition of success would have allowed 228 men to forego a second PVSA and prevented 2 (0.002%) unnecessary vasectomies, a savings of $6297. CONCLUSION PVSA compliance in our military cohort was similar to that of civilian counterparts. The American Urological Association vasectomy guidelines have the potential to decrease the number of repeat vasectomies and laboratory tests, improve the documented success rate, and increase follow-up compliance when applied to a military population. Published by Elsevier Inc. C1 [DeRosa, Raffaella] Tripler Army Med Ctr, Div Urol, Dept Surg, Honolulu, HI 96859 USA. Tripler Army Med Ctr, Dept Clin Invest, Honolulu, HI 96859 USA. RP DeRosa, R (reprint author), Tripler Army Med Ctr, Div Urol, Dept Surg, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM Raffaella.Derosa.mil@mail.mil NR 19 TC 2 Z9 2 U1 0 U2 1 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0090-4295 EI 1527-9995 J9 UROLOGY JI Urology PD MAR PY 2015 VL 85 IS 3 BP 505 EP 510 DI 10.1016/j.urology.2014.11.010 PG 6 WC Urology & Nephrology SC Urology & Nephrology GA CE6JJ UT WOS:000351942400011 PM 25559727 ER PT J AU Corbin, C AF Corbin, Christophe TI Universities in France: functioning and issues SO FRENCH REVIEW LA French DT Book Review C1 [Corbin, Christophe] US Mil Acad, West Point, NY 10996 USA. RP Corbin, C (reprint author), US Mil Acad, West Point, NY 10996 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC TEACHERS FRENCH PI CARBONDALE PA MAILCODE 4510, SOUTHERN ILLINOIS UNIV, CARBONDALE, IL 62901-4510 USA SN 0016-111X EI 2329-7131 J9 FR REV JI Fr. Rev. PD MAR PY 2015 VL 88 IS 3 BP 237 EP 238 PG 2 WC Literature, Romance SC Literature GA CC8JB UT WOS:000350613300048 ER PT J AU Yerry, JA Kuehn, D Finkel, AG AF Yerry, Juanita A. Kuehn, Devon Finkel, Alan G. TI Onabotulinum Toxin A for the Treatment of Headache in Service Members With a History of Mild Traumatic Brain Injury: A Cohort Study SO HEADACHE LA English DT Article DE traumatic brain injury; botulinum toxin; military; headache; migraine; chronic migraine ID POSTTRAUMATIC-STRESS-DISORDER; BOTULINUM TOXIN; US SOLDIERS; CHRONIC MIGRAINE; DOUBLE-BLIND; CERVICOGENIC HEADACHE; NUMMULAR HEADACHE; PROPHYLACTIC TREATMENT; INTERNATIONAL BURDEN; MILITARY PERSONNEL AB ObjectivePost-traumatic headache (PTH) of the migraine type is a common complication of mild traumatic brain injury (including blast injuries) in active duty service members. Persistent and near-daily headache occur. Usual preventive medications may have unacceptable side effects. Anecdotal reports suggest that onabotulinum toxin A (OBA) might be an effective treatment in these patients. MethodsThis study is a real-time retrospective consecutive case series of all patients treated with OBA at the Concussion Care Clinic of Womack Army Medical Center, Ft. Bragg, NC, between August 2008 and August 2012. Clinical treatment and pharmacy records were corroborated with the electronic medical records in the Armed Forces Health Longitudinal Technology Application to determine demographics, current headache and treatment characteristics, and clinical and occupational outcomes. ResultsSixty-four subjects (63 male) with mean age of 31.3 +/- 7.5 (range 20-59) years were evaluated and treated. Blast injuries were most common (n=36; 56.3%) and 7 patients (11%) reported a prior history of headache. Most patients (36; 56.3%) described more than 1 headache type and 48 (75%) patients had continuous pain. The most prevalent treating diagnosis was mixed continuous headache with migraine features on more than 15 days per month (n=26; 40.6%). The mean time from injury to the first injections was 10.8 +/- 21.9 (1-96) months. Forty (62.5%) patients received the Food and Drug Administration-approved chronic migraine injection protocol. Forty-one (64%) patients reported being better. Two patients discontinued for side effects. Twenty-seven (41%) remained on active duty. ConclusionsWe demonstrate that active duty military patients with headaches related to concussions may benefit from treatment with OBA. Further studies are indicated. C1 [Yerry, Juanita A.; Kuehn, Devon; Finkel, Alan G.] Womack Army Med Ctr, Dept Brain Injury Med, Ft Bragg, NC USA. [Finkel, Alan G.] Def & Vet Brain Injury Ctr, Silver Spring, MD USA. [Finkel, Alan G.] Carolina Headache Inst, Chapel Hill, NC USA. RP Finkel, AG (reprint author), Carolina Headache Inst, Headache Med, 6114 Fayetteville Rd, Durham, NC 27713 USA. EM finkela@chi09.com FU Defense and Veteran Brain Injury Centers FX One of the authors (AF) received salary support from the Defense and Veteran Brain Injury Centers in the conduct of this study and preparation of the manuscript. The views expressed herein are those of the presenters and do not reflect the official policy of the Department of the Army, Department of Defense, or the U.S. Government. NR 71 TC 11 Z9 11 U1 1 U2 2 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0017-8748 EI 1526-4610 J9 HEADACHE JI Headache PD MAR PY 2015 VL 55 IS 3 BP 395 EP 406 DI 10.1111/head.12495 PG 12 WC Clinical Neurology SC Neurosciences & Neurology GA CD6AS UT WOS:000351171200004 PM 25644249 ER PT J AU Dietlein, CR Bedair, SS Pulskamp, JS Meyer, CD Polcawich, RG AF Dietlein, Charles R. Bedair, Sarah S. Pulskamp, Jeffrey S. Meyer, Christopher D. Polcawich, Ronald G. TI Microfabricated Thick-Cu PZT-MEMS Millimeter-Wave Topologies and Devices SO IEEE MICROWAVE AND WIRELESS COMPONENTS LETTERS LA English DT Article DE MEMS; microfabrication; millimeter-wave; phase shifters; PZT; switches; transmission lines ID INDUCTORS AB This letter reports the design, fabrication, and performance of millimeter-wave transmission lines and devices in a tri-layer thick-copper (Cu) process. Beneath the Cu layers is a low-voltage lead zirconium titanate (PZT) MEMS stackup atop a nitride membrane, on high-resistivity silicon. The 10 mu m thick Cu layers enable several transmission-line topologies, and the PZT-MEMS functionality enables tunability. We designed transmission lines and un-optimized noncontact distributed MEMS transmission line (DMTL) phase shifters for 75-110 GHz, and present static measurements here. Simulation and measurements are in close agreement, with measured CPW line loss 0.15 dB greater than simulated (0.27 dB/mm at 95 GHz). Excess loss is attributed to Cu roughness, conductivity, and membrane/strap supports. Measured noncontact DMTL phase shifters exhibit a mean of 40 degrees/dB when intrinsic line loss is subtracted. C1 [Dietlein, Charles R.; Bedair, Sarah S.; Pulskamp, Jeffrey S.; Meyer, Christopher D.; Polcawich, Ronald G.] US Army Res Lab, Adelphi, MD 20783 USA. RP Dietlein, CR (reprint author), US Army Res Lab, Adelphi, MD 20783 USA. EM charles.r.dietlein.civ@mail.mil NR 10 TC 1 Z9 1 U1 1 U2 9 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1531-1309 EI 1558-1764 J9 IEEE MICROW WIREL CO JI IEEE Microw. Wirel. Compon. Lett. PD MAR PY 2015 VL 25 IS 3 BP 163 EP 165 DI 10.1109/LMWC.2015.2391993 PG 3 WC Engineering, Electrical & Electronic SC Engineering GA CE0AG UT WOS:000351463200007 ER PT J AU Hamed, AM Jayakumar, P Letherwood, MD Gorsich, DJ Recuero, AM Shabana, AA AF Hamed, Ashraf M. Jayakumar, Paramsothy Letherwood, Michael D. Gorsich, David J. Recuero, Antonio M. Shabana, Ahmed A. TI Ideal Compliant Joints and Integration of Computer Aided Design and Analysis SO JOURNAL OF COMPUTATIONAL AND NONLINEAR DYNAMICS LA English DT Article DE compliant joints; tracked vehicle; flexible multibody systems; finite element; ANCF; closed loop chains; I-CAD-A ID NODAL COORDINATE FORMULATION; MULTIBODY TRACKED VEHICLES; SPATIAL DYNAMICS; DEFORMABLE BEAM; FLOATING FRAME; ELEMENT; EQUATIONS; CONSTRAINTS; FORCES AB This paper discusses fundamental issues related to the integration of computer aided design and analysis (I-CAD-A) by introducing a new class of ideal compliant joints that account for the distributed inertia and elasticity. The absolute nodal coordinate formulation (ANCF) degrees of freedom are used in order to capture modes of deformation that cannot be captured using existing formulations. The ideal compliant joints developed can be formulated, for the most part, using linear algebraic equations, allowing for the elimination of the dependent variables at a preprocessing stage, thereby significantly reducing the problem dimension and array storage needed. Furthermore, the constraint equations are automatically satisfied at the position, velocity, and acceleration levels. When using the proposed approach to model large scale chain systems, differences in computational efficiency between the augmented formulation and the recursive methods are eliminated, and the central processing unit (CPU) times resulting from the use of the two formulations become similar regardless of the complexity of the system. The elimination of the joint constraint equations and the associated dependent variables also contribute to the solution of a fundamental singularity problem encountered in the analysis of closed loop chains and mechanisms by eliminating the need to repeatedly change the chain or mechanism independent coordinates. It is shown that the concept of the knot multiplicity used in computational geometry methods, such as B-spline and NURBS (nonuniform rational B-spline), to control the degree of continuity at the breakpoints is not suited for the formulation of many ideal compliant joints. As explained in this paper, this issue is closely related to the inability of B-spline and NURBS to model structural discontinuities. Another contribution of this paper is demonstrating that large deformation ANCF finite elements can be effective, in some multibody systems (MBS) applications, in solving small deformation problems. This is demonstrated using a heavily constrained tracked vehicle with flexible-link chains. Without using the proposed approach, modeling such a complex system with flexible links can be very challenging. The analysis presented in this paper also demonstrates that adding significant model details does not necessarily imply increasing the complexity of the MBS algorithm. C1 [Hamed, Ashraf M.; Recuero, Antonio M.; Shabana, Ahmed A.] Univ Illinois, Dept Mech & Ind Engn, Chicago, IL 60607 USA. [Jayakumar, Paramsothy; Letherwood, Michael D.; Gorsich, David J.] US Army RDECOM TARDEC, Warren, MI 48397 USA. RP Hamed, AM (reprint author), Univ Illinois, Dept Mech & Ind Engn, 842 West Taylor St, Chicago, IL 60607 USA. FU U.S. Army Tank-Automotive Research, Development and Engineering Center (TARDEC) [W911NF-07-D-0001]; Computational Dynamics Inc. FX This research was supported, in part, by the U.S. Army Tank-Automotive Research, Development and Engineering Center (TARDEC) (Contract No. W911NF-07-D-0001), and by Computational Dynamics Inc. NR 38 TC 4 Z9 4 U1 1 U2 16 PU ASME PI NEW YORK PA TWO PARK AVE, NEW YORK, NY 10016-5990 USA SN 1555-1423 EI 1555-1415 J9 J COMPUT NONLIN DYN JI J. Comput. Nonlinear Dyn. PD MAR PY 2015 VL 10 IS 2 AR 021015 DI 10.1115/1.4027999 PG 14 WC Engineering, Mechanical; Mechanics SC Engineering; Mechanics GA CD8MQ UT WOS:000351349700015 ER PT J AU Pasiakos, SM AF Pasiakos, Stefan M. TI Metabolic Advantages of Higher Protein Diets and Benefits of Dairy Foods on Weight Management, Glycemic Regulation, and Bone SO JOURNAL OF FOOD SCIENCE LA English DT Article DE body weight; bone; branched-chain amino acids; casein; muscle; whey ID RANDOMIZED CONTROLLED-TRIAL; CONVENTIONAL HIGH-CARBOHYDRATE; RESTING ENERGY-EXPENDITURE; CONTROLLED CLINICAL-TRIALS; OBESE PREMENOPAUSAL WOMEN; FAT-FREE MASS; BODY-COMPOSITION; SKELETAL-MUSCLE; LOSS MAINTENANCE; RESISTANCE EXERCISE AB The Inst. of Medicine and World Health Organization have determined that 0.8 to 0.83 g protein center dot kg(-1)center dot d(-1) is the quantity of protein required to establish nitrogen balance in nearly all healthy individuals. However, consuming higher protein diets may be metabolically advantageous, particularly for overweight and obese adults attempting weight loss, and for physically active individuals such as athletes and military personnel. Studies have demonstrated that higher protein diets may spare lean body mass during weight loss, promote weight management, enhance glycemic regulation, and increase intestinal calcium absorption, which may result in long-term improvements in bone health. The extent to which higher protein diets are beneficial is largely attributed to the digestive and absorptive properties, and also to the essential amino acid (EAA) content of the protein. Proteins that are rapidly digested and absorbed likely contribute to the metabolic advantages conferred by consuming higher protein diets. The EAA profiles, as well as the digestive and absorptive properties of dairy proteins, such as whey protein and casein, are particularly advantageous because they facilitate a rapid, robust, and sustained delivery of EAAs to the periphery. This article reviews the scientific literature assessing metabolic advantages associated with higher protein diets on weight management, glycemic regulation, and bone, with emphasis given to studies evaluating the potential benefits associated with dairy. C1 US Army Res Inst Environm Med, Mil Nutr Div, Natick, MA 01760 USA. RP Pasiakos, SM (reprint author), US Army Res Inst Environm Med, Mil Nutr Div, Natick, MA 01760 USA. EM stefan.pasiakos@us.army.mil RI Pasiakos, Stefan/E-6295-2014 OI Pasiakos, Stefan/0000-0002-5378-5820 FU U.S. Army Medical Research and Material Command; Dairy Management Inc. FX This work was supported by the U.S. Army Medical Research and Material Command. The author has received funding from Dairy Management Inc. for work not related to this project. No other conflicts of interest exist. NR 119 TC 5 Z9 5 U1 2 U2 41 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0022-1147 EI 1750-3841 J9 J FOOD SCI JI J. Food Sci. PD MAR PY 2015 VL 80 SU 1 BP A2 EP A7 DI 10.1111/1750-3841.12804 PG 6 WC Food Science & Technology SC Food Science & Technology GA CD6UM UT WOS:000351225100002 PM 25757894 ER PT J AU Melching, CS Liang, J Fleer, L Wethington, D AF Melching, Charles S. Liang, Jin Fleer, Lauren Wethington, David TI Modeling the water quality impacts of the separation of the Great Lakes and Mississippi River basins for invasive species control SO JOURNAL OF GREAT LAKES RESEARCH LA English DT Article DE Dissolved oxygen; Nutrients; Water quality modeling; Lake Michigan; Invasive species ID OXYGEN AB In 1900, the Chicago Sanitary and Ship Canal (CSSC) was opened to reverse the flow of the Chicago River and divert wastewater away from Lake Michigan and toward the Mississippi River. This reversal has been a public health success, but the CSSC and other components of the Chicago Area Waterway System (CAWS) have become conduits for invasive species to move between the Great Lakes and Mississippi River basins. The Great Lakes and Mississippi River Interbasin Study evaluated methods to prevent the migration of invasive species between the basins. The DUFLOW model was adapted to simulate water quality in the CAWS. This model is used to simulate conditions in the CAWS for the No Project (NP), Lakefront Separation (LS), and Midsystem Separation (MS) alternatives. Three representative water years (wet year, dry year, and normal year) are considered to compare the dissolved oxygen (DO) results and pollutant loads to Lake Michigan for the alternatives. The LS alternative results in large increases in noncompliance with DO standards with increases greater than 1000 h for several locations. The MS alternative results in large increases in noncompliance with DO standards in the waterways made stagnant by the placement of barriers with the Calumet-Sag Channel experiencing increases greater than 1000 h for nearly all locations evaluated. The loads to Lake Michigan for the MS alternative are greatly increased compared to the NP alternative with even the dry year modeled yielding loads of nitrogen, phosphorus, and chloride, 5.7, 0.73, and 150 million kg, respectively. (C) 2014 International Association for Great Lakes Research. Published by Elsevier B.V. All rights reserved. C1 [Melching, Charles S.] Private Consultant, Greenfield, WI 53221 USA. [Liang, Jin] Marquette Univ, Dept Civil Construct & Environm Engn, Milwaukee, WI 53201 USA. [Fleer, Lauren; Wethington, David] US Army Corps Engn, Chicago, IL 60604 USA. RP Melching, CS (reprint author), Private Consultant, 4030 W Edgerton Ave, Greenfield, WI 53221 USA. EM steve.melching17@gmail.com FU USGS [G11AP20226]; USACE [W912P6-12-0047] FX The project described in this report was supported by Grant/Cooperative Agreement Number G11AP20226 from the USGS and Contract Number W912P6-12-0047 from the USACE. The contents of this report are solely the responsibility of the authors and do not necessarily represent the official views of the USGS or USACE. Mention of trade names or commercial products in this report does not constitute their endorsement by the U.S. Government. NR 28 TC 1 Z9 1 U1 3 U2 19 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0380-1330 J9 J GREAT LAKES RES JI J. Gt. Lakes Res. PD MAR PY 2015 VL 41 IS 1 BP 87 EP 98 DI 10.1016/j.jglr.2014.11.009 PG 12 WC Environmental Sciences; Limnology; Marine & Freshwater Biology SC Environmental Sciences & Ecology; Marine & Freshwater Biology GA CE2NA UT WOS:000351651100009 ER PT J AU Whitehurst, SV Lockrow, EG Lendvay, TS Propst, AM Dunlow, SG Rosemeyer, CJ Gobern, JM White, LW Skinner, A Buller, JL AF Whitehurst, Sabrina V. Lockrow, Ernest G. Lendvay, Thomas S. Propst, Anthony M. Dunlow, Susan G. Rosemeyer, Christopher J. Gobern, Joseph M. White, Lee W. Skinner, Anna Buller, Jerome L. TI Comparison of Two Simulation Systems to Support Robotic-Assisted Surgical Training: A Pilot Study (Swine Model) SO JOURNAL OF MINIMALLY INVASIVE GYNECOLOGY LA English DT Article DE da Vinci Surgical System; dV-Trainer; Robotic surgery; Simulation; Virtual reality ID LAPAROSCOPIC SURGERY; PERFORMANCE; VALIDATION; SKILLS; TOOL AB Objective: To compare the efficacy of simulation-based training between the Mimic dV- Trainer and traditional dry lab da Vinci robot training. Design: A prospective randomized study analyzing the performance of 20 robotics-naive participants. Participants were enrolled in an online da Vinci Intuitive Surgical didactic training module, followed by training in use of the da Vinci standard surgical robot. Spatial ability tests were performed as well. Participants were randomly assigned to 1 of 2 training conditions: performance of 3 Fundamentals of Laparoscopic Surgery dry lab tasks using the da Vinci or performance of 4 dV-Trainer tasks. Participants in both groups performed all tasks to empirically establish proficiency criterion. Participants then performed the transfer task, a cystotomy closure using the daVinci robot on a live animal (swine) model. The performance of robotic tasks was blindly assessed by a panel of experienced surgeons using objective tracking data and using the validated Global Evaluative Assessment of Robotic Surgery (GEARS), a structured assessment tool. Results: No statistically significant difference in surgeon performance was found between the 2 training conditions, dV-Trainer and da Vinci robot. Analysis of a 95% confidence interval for the difference in means (-0.803 to 0.543) indicated that the 2 methods are unlikely to differ to an extent that would be clinically meaningful. Conclusion: Based on the results of this study, a curriculum on the dV- Trainer was shown to be comparable to traditional da Vinci robot training. Therefore, we have identified that training on a virtual reality system may be an alternative to live animal training for future robotic surgeons. Published by Elsevier Inc. on behalf of AAGL. C1 [Whitehurst, Sabrina V.; Dunlow, Susan G.; Gobern, Joseph M.] Walter Reed Natl Mil Med Ctr, Dept Obstet & Gynecol, Bethesda, MD USA. [Lockrow, Ernest G.; Propst, Anthony M.; Buller, Jerome L.] Uniformed Serv Univ Hlth Sci, Dept Obstet & Gynecol, Bethesda, MD 20814 USA. [Lendvay, Thomas S.] Seattle Childrens Hosp, Dept Urol, Seattle, WA USA. [Rosemeyer, Christopher J.] Tripler Army Med Ctr, Dept Obstet & Gynecol, Honolulu, HI 96859 USA. [White, Lee W.] Univ Washington, Dept Bioengn, Seattle, WA 98195 USA. [Skinner, Anna] Anthotronix, Silver Spring, MD USA. RP Lockrow, EG (reprint author), Uniformed Serv Univ Hlth Sci, Dept Obstet & Gynecol, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA. EM ernest.lockrow@usuhs.edu FU AMEDD Advanced Medical Technology Initiative under the Medical Research and Material Command, Telemedicine and Advanced Technology Research Center FX Funding was provided by a research grant from the AMEDD Advanced Medical Technology Initiative under the Medical Research and Material Command, Telemedicine and Advanced Technology Research Center. The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the US Department of the Army, Department of the Navy, Department of the Air Force, or Department of Defense. NR 14 TC 6 Z9 6 U1 0 U2 4 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1553-4650 EI 1553-4669 J9 J MINIM INVAS GYN JI J. Mimim. Invasive Gynecol. PD MAR-APR PY 2015 VL 22 IS 3 BP 483 EP 488 DI 10.1016/j.jmig.2014.12.160 PG 6 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA CE0FZ UT WOS:000351481200028 PM 25543068 ER PT J AU Brooks, JR Kerick, SE McDowell, K AF Brooks, Justin R. Kerick, Scott E. McDowell, Kaleb TI Novel Measure of Driver and Vehicle Interaction Demonstrates Transient Changes Related to Alerting SO JOURNAL OF MOTOR BEHAVIOR LA English DT Article DE alerting; driving behavior; sensorimotor transformation; steering wheel; time on task; visuomotor ID AUDITORY WARNING SIGNALS; VIGILANCE DECREMENT; STEERING CONTROL; FATIGUE; DROWSINESS; ATTENTION; TASK; EEG; MINDLESSNESS; PERFORMANCE AB Driver behavior and vehicle-road kinematics have been shown to change over prolonged periods of driving; however, the interaction between these two indices has not been examined. Here we develop a measure that examines how drivers turn the steering wheel relative to heading error velocity, which the authors call the relative steering wheel compensation (RSWC). The RSWC transiently changes on a short time scale coincident with a verbal query embedded within the study paradigm. In contrast, more traditional variables are dynamic over longer time scales consistent with previous research. The results suggest drivers alter their behavioral output (steering wheel correction) relative to sensory input (vehicle heading error velocity) on a distinct temporal scale and may reflect an interaction of alerting and control. C1 [Brooks, Justin R.; Kerick, Scott E.; McDowell, Kaleb] Army Res Lab, Human Res & Engn Directorate, Aberdeen Proving Ground, MD 21005 USA. [Brooks, Justin R.] Univ Maryland, Sch Med, Dept Med, College Pk, MD USA. RP Brooks, JR (reprint author), Army Res Lab, Human Res & Engn Directorate, Attn RDRL HRS C, Aberdeen Proving Ground, MD 21005 USA. EM jrybrooks@gmail.com FU U.S. Department of the Army; Oak Ridge Associated Universities; Army Research Laboratory [W911NF-12-2-0019] FX This work was funded by the U.S. Department of the Army and Oak Ridge Associated Universities. Research was sponsored by the Army Research Laboratory and was accomplished under Cooperative Agreement Number W911NF-12-2-0019. The views and conclusions contained in this document are those of the authors and should not be interpreted as representing official policies, either expressed or implied, of the Army Research Laboratory or the U.S. Government. The U.S. Government is authorized to reproduce and distribute reprints for Government purposes notwithstanding any copyright notation herein. NR 37 TC 0 Z9 0 U1 4 U2 13 PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND SN 0022-2895 EI 1940-1027 J9 J MOTOR BEHAV JI J. Mot. Behav. PD MAR-APR PY 2015 VL 47 IS 2 BP 106 EP 116 DI 10.1080/00222895.2014.959887 PG 11 WC Neurosciences; Psychology; Psychology, Experimental; Sport Sciences SC Neurosciences & Neurology; Psychology; Sport Sciences GA CD8MO UT WOS:000351349500006 PM 25356659 ER PT J AU Hagen, L Hebert, JJ Dekanich, J Koppenhaver, S AF Hagen, Lindsey Hebert, Jeffrey J. Dekanich, Joel Koppenhaver, Shane TI The Effect of Elastic Therapeutic Taping on Back Extensor Muscle Endurance in Patients With Low Back Pain: A Randomized, Controlled, Crossover Trial SO JOURNAL OF ORTHOPAEDIC & SPORTS PHYSICAL THERAPY LA English DT Article DE Biering-Sorensen test; lumbar spine; paraspinals ID RELIABILITY; DISABILITY; VALIDITY; SCALE AB STUDY DESIGN: Randomized, controlled, crossover trial. OBJECTIVES: To examine the effects of elastic therapeutic taping (ETT) applied to the lumbar paraspinal region on back muscle endurance (BME) compared to no tape or a rigid therapeutic taping (RTT) procedure in individuals with nonspecific low back pain. BACKGROUND: Elastic therapeutic taping is an increasingly popular intervention for clinicians who treat patients with low back pain. However, no studies have investigated the effect of ETT on back extensor muscle performance in a symptomatic population. METHODS: We measured BME in 16 patients (mean +/- SD age, 44.8 +/- 10.4 years; 44% female) with nonspecific low back pain. Back muscle endurance was measured using the Biering-Sorensen test under 3 different conditions: ETT, no tape, and RTT. For the ETT condition, the tape was applied over the paraspinal muscles according to the Kinesio Tex taping protocol. The RTT condition consisted of the same tape configuration but using nonelastic athletic tape. All participants received each testing condition in random order, with 1 to 3 days between each condition. Differences in BME between the 3 testing conditions were explored with repeated-measures analyses of variance. RESULTS: There were no differences in BME between ETT and RTT, or between the RTT and no-tape conditions. The difference in BME between the ETT and no-tape conditions was statistically significant (mean difference, 20.7 seconds; 95% confidence interval: 6.8, 34.5; P = .006) but within the threshold of measurement error. CONCLUSION: Back muscle endurance was higher with ETT applied over the paraspinal musculature when compared to a no-tape condition. However, the magnitude of difference did not exceed measurement error. There was no difference in BME when using elastic or rigid therapeutic tape. C1 [Hagen, Lindsey] Broadway Phys Therapy & Sports Rehabil, Portland, OR USA. [Hebert, Jeffrey J.; Koppenhaver, Shane] Murdoch Univ, Sch Psychol & Exercise Sci, Murdoch, WA 6150, Australia. [Dekanich, Joel] Vail Integrat Med Grp, Edwards, CO USA. [Koppenhaver, Shane] US Army Baylor Univ Doctoral Program Phys Therapy, Ft Sam Houston, TX USA. RP Hagen, L (reprint author), 3016 Northeast Broadway, Portland, OR 97232 USA. EM lindseyfitch6@gmail.com OI Hebert, Jeffrey/0000-0002-6959-325X NR 17 TC 0 Z9 0 U1 1 U2 17 PU J O S P T, PI ALEXANDRIA PA 1111 NORTH FAIRFAX ST, STE 100, ALEXANDRIA, VA 22314-1436 USA SN 0190-6011 J9 J ORTHOP SPORT PHYS JI J. Orthop. Sports Phys. Ther. PD MAR PY 2015 VL 45 IS 3 BP 215 EP 219 DI 10.2519/jospt.2015.5177 PG 5 WC Orthopedics; Rehabilitation; Sport Sciences SC Orthopedics; Rehabilitation; Sport Sciences GA CD7EI UT WOS:000351253200010 PM 25679343 ER PT J AU Flautt, W Westrick, R AF Flautt, Warren Westrick, Richard TI Cervical Myelopathy in a Special Operations Soldier SO JOURNAL OF ORTHOPAEDIC & SPORTS PHYSICAL THERAPY LA English DT Editorial Material C1 [Flautt, Warren] US Army Special Operat Command, Rehabil Program THOR3, Stuttgart, Germany. [Westrick, Richard] US Army Res Inst Environm Med, Environm Med Branch, Natick, MA USA. RP Flautt, W (reprint author), US Army Special Operat Command, Rehabil Program THOR3, Stuttgart, Germany. NR 0 TC 0 Z9 0 U1 0 U2 0 PU J O S P T, PI ALEXANDRIA PA 1111 NORTH FAIRFAX ST, STE 100, ALEXANDRIA, VA 22314-1436 USA SN 0190-6011 J9 J ORTHOP SPORT PHYS JI J. Orthop. Sports Phys. Ther. PD MAR PY 2015 VL 45 IS 3 BP 233 EP 233 DI 10.2519/jospt.2015.0403 PG 1 WC Orthopedics; Rehabilitation; Sport Sciences SC Orthopedics; Rehabilitation; Sport Sciences GA CD7EI UT WOS:000351253200012 PM 25726697 ER PT J AU Hack, DC AF Hack, Dallas C. TI Foreword SO MILITARY MEDICINE LA English DT Editorial Material C1 US Army Med Res & Mat Command, Combat Casualty Care Res Program Chair, Joint Program Comm 6, Ft Detrick, MD 21702 USA. RP Hack, DC (reprint author), US Army Med Res & Mat Command, Combat Casualty Care Res Program Chair, Joint Program Comm 6, Ft Detrick, MD 21702 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD MAR PY 2015 VL 180 IS 3 SU S BP 1 EP 1 DI 10.7205/MILMED-D-14-00648 PG 1 WC Medicine, General & Internal SC General & Internal Medicine GA CD3OQ UT WOS:000350988500001 PM 25747620 ER PT J AU Doll, BA AF Doll, Bruce A. TI Untitled SO MILITARY MEDICINE LA English DT Editorial Material C1 [Doll, Bruce A.] US Army Med Res & Mat Command, Ft Detrick, MD 21702 USA. [Doll, Bruce A.] US Army Med Res & Mat Command, Def Hlth Agcy, Res Dev & Acquisit Directorate, Ft Detrick, MD 21702 USA. RP Doll, BA (reprint author), US Army Med Res & Mat Command, 810 Schreider St, Ft Detrick, MD 21702 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD MAR PY 2015 VL 180 IS 3 SU S BP 2 EP 3 DI 10.7205/MILMED-D-14-00658 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA CD3OQ UT WOS:000350988500002 PM 25747621 ER PT J AU Reilly, PA Hatzfeld, JJ AF Reilly, Patricia A. Hatzfeld, Jennifer J. TI 2013 Military Health System Research Symposium Supplement: Issue Overview SO MILITARY MEDICINE LA English DT Editorial Material C1 [Reilly, Patricia A.] US Army Med Res & Mat Command, Off Principal Assistant Acquisit, Ft Detrick, MD 21702 USA. [Hatzfeld, Jennifer J.] Combat Casualty Care Res Program, Joint Program Comm 6, Ft Detrick, MD 21702 USA. RP Reilly, PA (reprint author), US Army Med Res & Mat Command, Off Principal Assistant Acquisit, 810 Schreider St, Ft Detrick, MD 21702 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD MAR PY 2015 VL 180 IS 3 SU S BP 4 EP 7 DI 10.7205/MILMED-D-14-00672 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA CD3OQ UT WOS:000350988500003 PM 25747622 ER PT J AU Dukes, S Tourtillott, B Bryant, D Carter, K McNair, S Maupin, G Tamminga, C AF Dukes, Susan Tourtillott, Brandon Bryant, Devin Carter, Kristina McNair, Shanelle Maupin, Genny Tamminga, Cindy TI Finishing What Was Started: An Analysis of Theater Research Conducted From 2010 to 2012 SO MILITARY MEDICINE LA English DT Article; Proceedings Paper CT Military Health Systems Research Symposium (MHSRS) CY AUG 13-16, 2012 CL Fort Lauderdale, FL AB The Joint Combat Casualty Research Team (JC2RT) is part of the human research protection regulatory system implemented in 2005 to oversee the conduct of research in a deployed military combatant command. In 2010, SharePoint, a web-based tool, was established to track study documents. This study conducted by JC2RT no. 13 describes characteristics of research studies under the purview of the JC2RT from 2010 through 2012. Of the 83 research studies reviewed, 34% were completed, 32% were not completed, and 34% were still in progress. Target sample sizes ranged from 12 to 70,000, with 96% of the research studying U.S. military members. The design of 61% of the studies was prospective, 20% surveys, and 14% retrospective reviews. Approximately one-half of the studies were conducted at single sites. Eighty-four percent of the studies that finished an institutional review board (IRB) were completed, whereas a large number of studies never made it to IRB approval. Even after studies have gone through the rigorous process of scientific review and IRB approval some continue to struggle for years to be completed in the theater of operations. The JC2RT is committed to helping facilitate the ethical conduct of research during war. C1 [Bryant, Devin] HQ USPACOM, Camp H M Smith, HI 96861 USA. [Carter, Kristina] Navy Environm & Preventat Med Unit, San Diego, CA 92136 USA. [McNair, Shanelle] US Army Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Tamminga, Cindy] Naval Med Res Ctr, Silver Spring, MD 20910 USA. RP Dukes, S (reprint author), 711 Human Performance Wing,2510 5th St Bldg 840s, Wright Patterson AFB, OH 45433 USA. FU USCENTCOM; U.S. Army Medical Research and Materiel Command IRB; U.S. Army Institute of Surgical Research FX The authors acknowledge the support of USCENTCOM, U.S. Army Medical Research and Materiel Command IRB, U.S. Army Institute of Surgical Research, previous JC2RT team members, and Elizabeth Krech. NR 4 TC 0 Z9 0 U1 0 U2 3 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD MAR PY 2015 VL 180 IS 3 SU S BP 8 EP 13 DI 10.7205/MILMED-D-14-00393 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA CD3OQ UT WOS:000350988500004 PM 25747623 ER PT J AU Petz, LN Tyner, S Barnard, E Ervin, A Mora, A Clifford, J Fowler, M Bebarta, VS AF Petz, Lawrence N. Tyner, Stuart Barnard, Ed Ervin, Alicia Mora, Alex Clifford, John Fowler, Marcie Bebarta, Vikhyat S. TI Prehospital and En Route Analgesic Use in the Combat Setting: A Prospectively Designed, Multicenter, Observational Study SO MILITARY MEDICINE LA English DT Article; Proceedings Paper CT Military Health Systems Research Symposium (MHSRS) CY AUG 13-16, 2012 CL Fort Lauderdale, FL ID PAIN MANAGEMENT; TRAUMA ANALGESIA; CASUALTY CARE; KETAMINE; BATTLEFIELD; MORPHINE; RELIEF; IRAQ; WAR AB Background: Combat injuries result in acute, severe pain. Early use of analgesia after injury is known to be beneficial. Studies on prehospital analgesia in combat are limited and no prospectively designed study has reported the use of analgesics in the prehospital and en route care setting. Our objective was to describe the current use of prehospital analgesia in the combat setting. Methods: This prospectively designed, multicenter, observational, prehospital combat study was undertaken at medical treatment facilities (MTF) in Afghanistan between October 2012 and September 2013. It formed part of a larger study aimed at describing the use of lifesaving interventions in combat. On arrival at the MTF, trained on-site investigators enrolled eligible patients and completed standardized data capture forms, which included the name, dose, and route of administration of all prehospital analgesics, and the type of provider who administered the drug. Physiological data were retrospectively ascribed as soon as practicable. The study was prospectively approved by the Brooke Army Medical Center institutional review board. Results: Data were collected on 228 patients, with 305 analgesia administrations recorded. The predominant mechanism of injury was blast (50%), followed by penetrating (41%), and blunt (9%). The most common analgesic used was ketamine, followed by morphine. A combination of analgesics was given to 29% of patients; the most common combination was ketamine and morphine. Intravenous delivery was the most commonly used route (55%). Patients transported by the UK Medical Emergency Response Team (MERT) or U.S. Air Medical Evacuation (Dust-off) team were more likely to receive ketamine than those evacuated by U.S. Pararescue Jumpers (Pedro). Patients transported by Medical Emergency Response Team or Pedro were more likely to receive more than 1 drug. Patients who received only ketamine had a higher pulse rate (p < 0.005) and lower systolic blood pressure (p = 0.01) than other groups, and patients that received hydromorphone had a lower respiratory rate (p = 0.04). Conclusions: In our prospectively designed, multicenter, observational, prehospital combat study, ketamine was the most commonly used analgesic drug. The most frequently observed combination of drugs was ketamine and morphine. The intravenous route was used for 55% of drug administrations. C1 [Petz, Lawrence N.; Clifford, John; Fowler, Marcie] US Army Inst Surg Res, San Antonio Mil Med Ctr, Battlefield Pain Management, Jbsa Ft Sam Houston, TX 78234 USA. [Barnard, Ed; Ervin, Alicia; Mora, Alex; Bebarta, Vikhyat S.] US Army Inst Surg Res, San Antonio Mil Med Ctr, Air Force En Route Care Res Ctr, Jbsa Ft Sam Houston, TX 78234 USA. [Tyner, Stuart] US Army Inst Surg Res, San Antonio Mil Med Ctr, Dept Emergency Med, Jbsa Ft Sam Houston, TX 78234 USA. [Barnard, Ed] Inst Naval Med, Alverstoke PO12 2DL, England. RP Petz, LN (reprint author), US Army Inst Surg Res, San Antonio Mil Med Ctr, Battlefield Pain Management, 3698 Chambers Pass, Jbsa Ft Sam Houston, TX 78234 USA. RI bebarta, vikhyat/K-3476-2015 FU Air Force Medical Support Agency [EM-I-12-005] FX This study was funded by Air Force Medical Support Agency (EM-I-12-005). We thank the current and former members of the on-site Joint Combat Casualty Research Team that helped to collect critical data to make this study possible and John Jones of USAISR for statistical analysis assistance. NR 30 TC 1 Z9 2 U1 1 U2 2 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD MAR PY 2015 VL 180 IS 3 SU S BP 14 EP 18 DI 10.7205/MILMED-D-14-00383 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA CD3OQ UT WOS:000350988500005 PM 25747624 ER PT J AU Hinojosa-Laborde, C Aden, JK Goei, KA Convertino, VA AF Hinojosa-Laborde, Carmen Aden, James K. Goei, Kathleen A. Convertino, Victor A. TI Evidence for a Higher Risk of Hypovolemia-Induced Hemodynamic Instability in Females: Implications for Decision Support During Prehospital Triage SO MILITARY MEDICINE LA English DT Article; Proceedings Paper CT Military Health Systems Research Symposium (MHSRS) CY AUG 13-16, 2012 CL Fort Lauderdale, FL ID BODY NEGATIVE-PRESSURE; ORTHOSTATIC TOLERANCE; GENDER-DIFFERENCES; CARDIOVASCULAR-RESPONSES; WOMEN; MODEL; SHOCK; HUMANS; LBNP; MEN AB Lower body negative pressure (LBNP) simulates hemorrhage, and tolerance to LBNP (time to presyncope [TTP]) is indicative of tolerance to blood loss. The purpose of this study was to predict TTP based on demographic characteristics (sex, age, height, and body mass index) and physiological variables (heart rate [HR], systolic arterial pressure, diastolic arterial pressure [DAP], pulse pressure, stroke volume, total peripheral resistance [TPR], and baroreflex sensitivity [BRS]) at baseline, and during 2 levels of LBNP (-15, -30 mm Hg). Multiple linear regression analysis was used to create a model to predict TTP (range: 670 to 2516 seconds, n = 187) based on demographic characteristics and physiological variables changes (Delta) from baseline to -30 mm Hg LBNP. The prediction model revealed that TTP (seconds) = 1667.5 + (5.1 x Age) + (61.1 x Sex) - (21.5 x Delta HR) + (55.3 x Delta DAP) - (88.2 + Delta TPR) - (4.9 x Delta BRS). Most significantly, our analysis demonstrated a lesser survival trajectory for females given the same rate and magnitude of hemorrhage compared to males. Young age and female sex are predictors of low tolerance to blood loss, and should be considered for early triage in the prehospital setting. C1 [Hinojosa-Laborde, Carmen; Aden, James K.; Convertino, Victor A.] US Army Inst Surg Res, Jbsa Ft Sam Houston, TX 78234 USA. [Goei, Kathleen A.] Univ Incarnate Word, San Antonio, TX 78209 USA. RP Hinojosa-Laborde, C (reprint author), US Army Inst Surg Res, 3698 Chambers Pass, Jbsa Ft Sam Houston, TX 78234 USA. FU U.S. Army Medical Research and Materiel Command Combat Casualty Care Research Program FX This research was supported by funding from the U.S. Army Medical Research and Materiel Command Combat Casualty Care Research Program. NR 29 TC 0 Z9 0 U1 0 U2 2 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD MAR PY 2015 VL 180 IS 3 SU S BP 19 EP 23 DI 10.7205/MILMED-D-14-00394 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA CD3OQ UT WOS:000350988500006 PM 25747625 ER PT J AU Mitchell, TA Wallum, TE Becker, TE Aden, JK Bailey, JA Blackbourne, LH White, CE AF Mitchell, Thomas A. Wallum, Timothy E. Becker, Tyson E. Aden, James K. Bailey, Jeffrey A. Blackbourne, Lorne H. White, Christopher E. TI Nonoperative Management of Splenic Injury in Combat: 2002-2012 SO MILITARY MEDICINE LA English DT Article; Proceedings Paper CT Military Health Systems Research Symposium (MHSRS) CY AUG 13-16, 2012 CL Fort Lauderdale, FL ID TRAUMA AB Background: Selective nonoperative management of combat-related blunt splenic injury (BSI) is controversial. We evaluated the impact of the November 2008 blunt abdominal trauma clinical practice guideline that permitted selective nonoperative management of some patients with radiological suggestion of hemoperitoneum on implementation of nonoperative management (NOM) of splenic injury in austere environments. Methods: Retrospective evaluation of patients with splenic injuries from November 2002 through January 2012 in Iraq and Afghanistan was performed. International Classification of Diseases, 9th Revision, Clinical Modification procedure codes identified patients as laparotomy with splenectomy, or NOM. Delayed operative management had no operative intervention at earlier North American Treaty Organization (NATO) medical treatment facilities (MTFs), and had a definitive intervention at a latter NATO MTFs. Intra-abdominal complications and overall mortality were juxtaposed. Results: A total of 433 patients had splenic injuries from 2002 to 2012. Initial NOM of BSI from 2002 to 2008 compared to 2009-2012 was 44.1% and 47.2%, respectively (p = 0.75). Delayed operative management and NOM completion had intra-abdominal complication and mortality rates of 38.1% and 9.1% (p < 0.01), and 6.3% and 8.1% (p = 0.77). Conclusions: Despite high-energy explosive injuries, NATO Role II MTFs radiological constraints and limited medical resources, hemodynamically normal patients with BSI and low abdominal abbreviated injury scores underwent NOM in austere environments. C1 [Mitchell, Thomas A.; Becker, Tyson E.; Blackbourne, Lorne H.; White, Christopher E.] US Mil Gen Surg, San Antonio Mil Med Ctr, San Antonio, TX 78234 USA. [Wallum, Timothy E.; Aden, James K.; Bailey, Jeffrey A.] US Army Inst Surg Res, Jbsa Ft Sam Houston, TX 78234 USA. RP Mitchell, TA (reprint author), US Mil Gen Surg, San Antonio Mil Med Ctr, 3851 Roger Brooke Dr 3600, San Antonio, TX 78234 USA. NR 9 TC 0 Z9 0 U1 1 U2 1 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD MAR PY 2015 VL 180 IS 3 SU S BP 29 EP 32 DI 10.7205/MILMED-D-14-00411 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA CD3OQ UT WOS:000350988500008 PM 25747627 ER PT J AU Mitchell, TA Waldrep, KB Sams, VG Wallum, TE Blackbourne, LH White, CE AF Mitchell, Thomas A. Waldrep, Kevin B. Sams, Valerie G. Wallum, Timothy E. Blackbourne, Lorne H. White, Christopher E. TI An 8-Year Review of Operation Enduring Freedom and Operation Iraqi Freedom Resuscitative Thoracotomies SO MILITARY MEDICINE LA English DT Article; Proceedings Paper CT Military Health Systems Research Symposium (MHSRS) CY AUG 13-16, 2012 CL Fort Lauderdale, FL ID TRAUMA AB Background: Appropriate indications for resuscitative thoracotomy (RT) in an austere environment continue to evolve; the aim of this study was to determine survival and to analyze demographics of survivors within U.S. military personnel undergoing RT. Methods: A retrospective review was performed of all U.S. soldiers who underwent thoracotomy in theater during Operation Iraqi Freedom and Operation Enduring Freedom. After individualized review, patients in extremis or who lost pulses and had their thoracotomy performed within 10 minutes of arrival to the emergency department were included. The primary outcome was survival at final hospital discharge, and secondary outcomes included demographics associated with survival. Results: Between January 2003 and May 2010, 81 U.S. military personnel met inclusion criteria for RT in theater. As low as 6.7% (3/45) of patients receiving prehospital cardiopulmonary resuscitation were alive at final hospital discharge. Survival from RT after explosive/blast injury, penetrating (gunshot wound), and blunt trauma were 16.3% (8/49), 0% (0/28), and 0% (0/4), respectively. Patients with primary explosive/blast extremity trauma undergoing RT had a survival of 27.3% (6/22). Higher initial oxygen saturations, larger volume of crystalloids and blood products infused, and higher extremity abbreviated injury score were all associated with survival. Conclusions: Combat casualties who present pulseless or in extremis who were injured as a result of an explosive/blast injury mechanism resulting in a primary extremity injury may have a survival benefit from undergoing a RT in an austere environment. C1 [Mitchell, Thomas A.; Waldrep, Kevin B.; Sams, Valerie G.; Blackbourne, Lorne H.; White, Christopher E.] US Mil Gen Surg, San Antonio Mil Med Ctr, San Antonio, TX 78234 USA. [Wallum, Timothy E.] US Army Inst Surg Res, Jbsa Ft Sam Houston, TX 78234 USA. RP Mitchell, TA (reprint author), US Mil Gen Surg, San Antonio Mil Med Ctr, 3851 Roger Brooke Dr 3600, San Antonio, TX 78234 USA. FU U.S. Military FX The authors acknowledge the Department of Defense Trauma Registry and the Patient Administration Systems and Biostatistics Activity for providing data for this study. We also thank Ms. Alison Ramsey for her assistance with critical editing. The authors would like to disclose that no external funds were used to finance this project, and the U.S. Military was solely responsible for funding this research. NR 13 TC 2 Z9 2 U1 0 U2 0 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD MAR PY 2015 VL 180 IS 3 SU S BP 33 EP 36 DI 10.7205/MILMED-D-14-00440 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA CD3OQ UT WOS:000350988500009 PM 25747628 ER PT J AU Waters, JA Lundy, JB Aden, JK Sine, CR Buel, AR Henderson, JL Stewart, IJ Cannon, JW Batchinsky, A Cancio, LC Chung, KK AF Waters, J. Alan Lundy, Jonathan B. Aden, James K. Sine, Christy R. Buel, Allison R. Henderson, Jonathan L. Stewart, Ian J. Cannon, Jeremy W. Batchinsky, Andriy Cancio, Leopoldo C. Chung, Kevin K. TI A Comparison of Acute Respiratory Distress Syndrome Outcomes Between Military and Civilian Burn Patients SO MILITARY MEDICINE LA English DT Article; Proceedings Paper CT Military Health Systems Research Symposium (MHSRS) CY AUG 13-16, 2012 CL Fort Lauderdale, FL ID INHALATION INJURY; THERMAL-INJURY; MORTALITY; SCORE; PROBABILITY; VICTIMS; DEATH; RISK; AGE AB Background: The objective of this report was to compare the prevalence of acute respiratory distress syndrome (ARDS) and associated mortality between military service members with burns sustained during or in support of combat operations and civilian burn patients treated at a single burn center. Methods: Demographic and physiologic data were collected retrospectively on mechanically ventilated military and civilian patients admitted to our burn intensive care unit between January 2003 and December 2011. Patients with ARDS were identified and categorized as mild, moderate, or severe using the Berlin criteria. Demographics and clinical outcomes were compared. After initial comparison, propensity matching was performed and mortality compared. Results: A total of 891 burn patients required mechanical ventilation during the study period; 291 military and 600 civilian. The prevalence of ARDS was 34% (n = 304) for the entire cohort, 33% (n = 96) for military, and 35% (n = 208) for civilians (p = 0.55). For the entire cohort, despite more severe injury burden, military patients had a significantly lower overall mortality (17% vs. 28%; p = 0.0002) as well as ARDS mortality (33 vs. 48%, p = 0.02) when compared to civilians. This difference was not significant after propensity matching based on age. Conclusion: In a retrospective cohort study, burned military patients on mechanical ventilation had a significantly lower overall and ARDS mortality despite larger burns and more severe injury when compared to civilian burn patients. This difference appears to be largely because of age. C1 [Waters, J. Alan; Lundy, Jonathan B.; Aden, James K.; Batchinsky, Andriy; Cancio, Leopoldo C.; Chung, Kevin K.] US Army Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Sine, Christy R.; Buel, Allison R.; Henderson, Jonathan L.; Stewart, Ian J.; Cannon, Jeremy W.] San Antonio Mil Med Ctr, Dept Med, Ft Sam Houston, TX 78234 USA. [Chung, Kevin K.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. RP Waters, JA (reprint author), US Army Inst Surg Res, 3698 Chambers Pass Rd,Suite B, Ft Sam Houston, TX 78234 USA. FU Clinical Trials for Burns and Trauma Task Area, U.S. Army Institute of Surgical Research FX K.K.C. contributed to the original conception of the study. S.M.B., A.R.B., C.R.S., I.J.S., and J.L.H. performed the data extraction and management. J.K.A., J.A.W., and K.K.C. performed the data analysis and created the charts and figures. J.A.W. and J. B. L. wrote the manuscript. I.J.S., J.W.C., A.B., L.C.C. and K.K.C. critically reviewed the manuscript. K.K.C. directed the study team and approved the final manuscript. Funding for this study was provided by the Clinical Trials for Burns and Trauma Task Area, U.S. Army Institute of Surgical Research. NR 17 TC 3 Z9 3 U1 0 U2 0 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD MAR PY 2015 VL 180 IS 3 SU S BP 56 EP 59 DI 10.7205/MILMED-D-14-00390 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA CD3OQ UT WOS:000350988500013 PM 25747632 ER PT J AU Schauer, SG Bellamy, MA Mabry, RL Bebarta, VS AF Schauer, Steven G. Bellamy, Michael A. Mabry, Robert L. Bebarta, Vikhyat S. TI A Comparison of the Incidence of Cricothyrotomy in the Deployed Setting to the Emergency Department at a Level 1 Military Trauma Center: A Descriptive Analysis SO MILITARY MEDICINE LA English DT Article; Proceedings Paper CT Military Health Systems Research Symposium (MHSRS) CY AUG 13-16, 2012 CL Fort Lauderdale, FL ID SURGICAL CRICOTHYROIDOTOMY; MEDICINE RESIDENCY; AIRWAY MANAGEMENT; INTUBATION; SUCCESS; SKILLS AB Airway management is a critical skill of emergency medicine physicians and prehospital providers. Airway compromise is the cause of 1.8% of battlefield deaths. Cricothyrotomy is a critical, lifesaving procedure. In this study, we conducted a retrospective descriptive analysis comparing the incidence of cricothyrotomies in the deployed setting versus the incidence in a military level 1 trauma center emergency department (ED) setting in San Antonio, Texas. The deployed/in-theater procedures were performed from September 2007 to July 2009. The ED procedures were performed from April 2010 to February 2012. Over these study periods, 28 cricothyrotomies were performed in the deployed setting against a backdrop of 11,492 trauma admissions compared to 4 cricothyrotomies performed during 2,741 trauma admissions in the ED setting. The per admission incidence of deployed cricothyrotomies was 0.24% versus an incidence of 0.15% in the ED (p = 0.46). We conclude that this rare, lifesaving procedure is performed more often in the deployed setting than the ED, but this difference was not statistically significant. C1 [Schauer, Steven G.] Bayne Jones Army Community Hosp, Ft Polk, LA 71459 USA. [Bellamy, Michael A.] Martin Army Community Hosp, Ft Benning, GA 31905 USA. [Mabry, Robert L.] San Antonio Mil Med Ctr, Ft Sam Houston, TX 78234 USA. [Bebarta, Vikhyat S.] US Army Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Schauer, SG (reprint author), Bayne Jones Army Community Hosp, 1585 3rd St, Ft Polk, LA 71459 USA. RI bebarta, vikhyat/K-3476-2015 NR 20 TC 2 Z9 2 U1 0 U2 1 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD MAR PY 2015 VL 180 IS 3 SU S BP 60 EP 63 DI 10.7205/MILMED-D-14-00384 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA CD3OQ UT WOS:000350988500014 PM 25747633 ER PT J AU Martini, WZ Deguzman, R Rodriguez, CM Guerra, J Martini, AK Pusateri, AE Dubick, MA AF Martini, Wenjun Z. Deguzman, Rodolfo Rodriguez, Cassandra M. Guerra, Jessica Martini, Angela K. Pusateri, Anthony E. Dubick, Michael A. TI Effect of Ibuprofen Dose on Platelet Aggregation and Coagulation in Blood Samples From Pigs SO MILITARY MEDICINE LA English DT Article; Proceedings Paper CT Military Health Systems Research Symposium (MHSRS) CY AUG 13-16, 2012 CL Fort Lauderdale, FL ID LIVER-DISEASE; OVERDOSE; TRAUMA; PLASMA AB Introduction: Ibuprofen is commonly used by Soldiers in the deployed environment. This study investigated its dose-effects on in vitro coagulation. Methods: Blood samples were collected from 4 normal healthy pigs and were processed to make platelet-adjusted (100 x 10(3)/mu L) blood samples. Ibuprofen was added to the samples at doses of 0 mu g/mL (control), recommended oral dose (163 mu g/mL, 1 x), 2 x, 4 x, 8 x, 10 x, 12 x, 16 x, and 20 x. Arachidonic acid or collagen-stimulated platelet aggregation was assessed at 15 minutes after the addition of ibuprofen. Coagulation was assessed with measurements of prothrombin time (PT) and activated partial thromboplastin time (aPTT), and thrombelastography by Rotem. Results: A robust inhibition of ibuprofen on arachidonic acid-induced platelet aggregation was observed at all doses tested. Collagen-stimulated platelet aggregation was inhibited to 71% +/- 5% and 10% +/- 5% of the control values at ibuprofen doses of 4 x and 20 x, respectively (both p < 0.05). No changes were observed in PT at any dose, but aPTT was prolonged at dose of 16 x and 20 x. Rotem measurements of coagulation time, clot formation time, maximum clot firmness, and A10 were compromised at dose 16 x and 20 x (all p < 0.05). Conclusion: Ibuprofen inhibited platelet aggregation at recommended doses, but did not compromise aPTT or coagulation profile until at 16 times the recommended doses and higher. Further effort is needed to clarify whether there are different dose-responses between human and pig blood samples in trauma situations. C1 [Martini, Wenjun Z.; Deguzman, Rodolfo; Rodriguez, Cassandra M.; Guerra, Jessica; Dubick, Michael A.] US Army Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Martini, Angela K.] Rice Univ, Houston, TX 77251 USA. [Pusateri, Anthony E.] US Army Med Res & Mat Command, Ft Detrick, MD 21702 USA. RP Martini, WZ (reprint author), US Army Inst Surg Res, 3698 Chambers Pass, Ft Sam Houston, TX 78234 USA. FU Laboratory Support Section at the U.S. Army Institute of Surgical Research; U.S. Army Medical Research and Materiel Command FX We appreciate the support received from the Laboratory Support Section at the U.S. Army Institute of Surgical Research in coagulation measurements. We thank Mr. John Jones for his assistance with statistical analysis. This study was supported by the U.S. Army Medical Research and Materiel Command. NR 35 TC 1 Z9 1 U1 1 U2 2 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD MAR PY 2015 VL 180 IS 3 SU S BP 80 EP 85 DI 10.7205/MILMED-D-14-00395 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA CD3OQ UT WOS:000350988500018 PM 25747637 ER PT J AU Dinos, ME Borke, JL Swiec, GD McPherson, JC Goodin, JL Chuang, AH AF Dinos, Michael E. Borke, James L. Swiec, Gary D. McPherson, James C., III Goodin, Jeremy L. Chuang, Augustine H. TI In Vitro Study of the Adverse Effect of Nicotine and Physical Strain on Human Gingival Fibroblasts as a Model of the Healing of Wounds Commonly Found in the Military SO MILITARY MEDICINE LA English DT Article; Proceedings Paper CT Military Health Systems Research Symposium (MHSRS) CY AUG 13-16, 2012 CL Fort Lauderdale, FL ID SMOOTH-MUSCLE-CELLS; TOBACCO PROMOTION; CYCLIC STRETCH; OSTEOBLASTS; ATTACHMENT; EXPRESSION; SMOKING; INVITRO; MECHANOTRANSDUCTION; PERSONNEL AB Background: Significant adverse effects on fibroblast growth and metabolism are observed with nicotine. We investigated the synergistic effects of nicotine and cyclical mechanical strain (CMS) on human gingival fibroblasts (HGFs) in a wound-healing model. Methods: HGFs were isolated and grown in Dulbecco's modified Eagle's medium. Three-millimeter wounds were created on a confluent cell monolayer grown in a media containing 0, 1, 2, or 4 mM nicotine, with or without CMS. The applied deformation regimen remains constant for 6 days. On days 1, 2, 4, and 6, the cells were stained with hematoxylin and eosin Y for the evaluation of wound repopulation. Results: The application of CMS alone demonstrates a biphasic response, with an initial stimulatory effect on wound repopulation (days 1-2) and less repopulation during the later phase (days 4-6). The addition of nicotine clearly demonstrated a time and inverse dose-dependent relationship on wound repopulation, with no effect during the early phase and reduced wound repopulation during the later phase. Conclusions: Initial treatment of HGF wounds with CMS resulted in faster wound repopulation regardless of nicotine presence. By day 6, wound healing of HGF exposed to both nicotine and CMS is delayed. These findings suggest that CMS and nicotine may affect fibroblasts and delay wound healing at other sites in the body as well. C1 [Dinos, Michael E.; Swiec, Gary D.] Tingay Dent Clin, Ft Gordon, GA 30905 USA. [McPherson, James C., III; Goodin, Jeremy L.; Chuang, Augustine H.] DD Eisenhower Army Med Ctr, Dept Clin Invest, Ft Gordon, GA 30905 USA. [Borke, James L.] Western Univ Hlth Sci, Coll Dent Med, Pomona, CA 91766 USA. RP Dinos, ME (reprint author), Tingay Dent Clin, 320 East Hosp Rd,Bldg 320, Ft Gordon, GA 30905 USA. NR 37 TC 1 Z9 2 U1 2 U2 6 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD MAR PY 2015 VL 180 IS 3 SU S BP 86 EP 91 DI 10.7205/MILMED-D-14-00382 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA CD3OQ UT WOS:000350988500019 PM 25747638 ER PT J AU Hwang, JI Chuang, AH Sidow, SJ McNally, K Goodin, JL McPherson, JC AF Hwang, Jae I. Chuang, Augustine H. Sidow, Stephanie J. McNally, Kathleen Goodin, Jeremy L. McPherson, James C., III TI The Effectiveness of Endodontic Solvents to Remove Endodontic Sealers SO MILITARY MEDICINE LA English DT Article; Proceedings Paper CT Military Health Systems Research Symposium (MHSRS) CY AUG 13-16, 2012 CL Fort Lauderdale, FL ID PROTAPER UNIVERSAL RETREATMENT; ROOT-CANAL RETREATMENT; GUTTA-PERCHA; SETTING TIMES; EFFICACY; INSTRUMENTATION; CHLOROFORM; READINESS; ROTARY; FILES AB Dental emergencies negatively affect troop readiness, especially during combat. Endodontic retreatment, when required, is especially challenging when the removal of endodontic sealer is required. In this study, we investigated the effectiveness of synthetic endodontic solvents to remove endodontic sealers. Fifty capillary tubes (2.7 mm ID x 22 mm L), each filled to 15 mm with either Roth 801, AH Plus, MetaSEAL, or gutta-percha, were stored at 75% humidity for 14 days at 37 degrees C. Ten capillary tubes containing each sealer were treated with either chloroform, xylene, EndoSolv R, EndoSolv E, or no solvent, and then penetrated with D3 ProTaper Universal Retreatment file on the same day. The time for the file to penetrate the length of each sealer was recorded, and the data statistically analyzed. Roth 801 failed to set and was not tested. The file took 3.4 +/- 0.1, 4.8 +/- 0.3, 5.7 +/- 0.4, 4.5 +/- 0.2, and 10.6 +/- 1.0 seconds (mean +/- SD) to penetrate gutta-percha using chloroform, xylene, EndoSolv R, EndoSolv E, or no solvent, respectively, and was performed by one endodontic resident at one sitting. The time for penetration of gutta-percha with any solvent was significantly faster (p <= 0.05) than for AH Plus or MetaSEAL. The time for AH Plus ranged from 23.1 +/- 1.0 to 81.5 +/- 4.5 seconds. The time for MetaSEAL ranged from 97.2 +/- 6.1 to > 180 seconds. EndoSolv E was the most effective solvent for AH Plus. It took significantly more time to remove MetaSEAL than AH Plus, regardless of the solvent used. Our study indicated that the use of the proper endodontic solvent makes complete removal of a sealer much more effective during retreatment. C1 [Hwang, Jae I.; Sidow, Stephanie J.; McNally, Kathleen] Tingay Army Dent Clin, Ft Gordon, GA 30905 USA. [Chuang, Augustine H.; Goodin, Jeremy L.; McPherson, James C., III] DD Eisenhower Army Med Ctr, Dept Clin Invest, Ft Gordon, GA 30905 USA. RP Hwang, JI (reprint author), Tingay Army Dent Clin, 320 East Hosp Rd,Bldg 320, Ft Gordon, GA 30905 USA. NR 25 TC 0 Z9 0 U1 1 U2 5 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD MAR PY 2015 VL 180 IS 3 SU S BP 92 EP 95 DI 10.7205/MILMED-D-14-00379 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA CD3OQ UT WOS:000350988500020 PM 25747639 ER PT J AU Lattimore, MR AF Lattimore, Morris R. TI Brief Report: A Hypothetical Construct Based on Limited Data Visual System Recovery After Refractive Surgery SO MILITARY MEDICINE LA English DT Article; Proceedings Paper CT Military Health Systems Research Symposium (MHSRS) CY AUG 13-16, 2012 CL Fort Lauderdale, FL ID PLASTICITY AB Laser refractive surgery, involving the computer-controlled application of a 193-nm beam of excimer laser "light," is utilized to resculpt the central cornea, thus reducing its apical thickness. On casual inspection, this simple matter of removing or excising a specific amount of central corneal avascular tissue is a smooth, seamless alteration with few apparent secondary issues or sequelae. Normal postoperative recovery is typically gauged by the recovery of high-contrast visual acuity to the same (or better) degree as was previously obtained with a spectacle correction. However, although this is an acceptable means of determining operative success, it is not indicative of the complex challenges imposed upon the neurosensory system. The secondarily imposed strain upon the visual system, regarding the return to its pre-existing visual line-of-sight organization occurs only by bringing multiple adaptations into subtle and seamless play. This process is initiated and completed in a relatively short time period, such that most patients (but not all) are not even marginally aware of the challenges imposed to the visual system. This article is meant to probe those system challenges, serving to highlight this postoperative plasticity, seeking to gain a broader understanding and appreciation of the perceptual range of the visual recovery process. C1 US Army Aeromed Res Lab, Ft Rucker, AL 36362 USA. RP Lattimore, MR (reprint author), US Army Aeromed Res Lab, 6901 Farrell Rd, Ft Rucker, AL 36362 USA. FU Naval Refractive Surgery Research Program at the Naval Regional Medical Center-San Diego (NRMC-SD) FX A special thank you is submitted to the Balboa Medical Center clinical and scientific staff, and to the Navy Health Research Laboratory research staff. Their gracious voluntary acceptance of my presence into their fold was an unexpected additional benefit to my Joint Research assignment. Data were gathered under the fiscal auspices of the Naval Refractive Surgery Research Program at the Naval Regional Medical Center-San Diego (NRMC-SD); this analytical report stems from a Medical Research and Materiel Command-Intra-Laboratory In-house Research (MRMC-ILIR) award to the U.S. Army Aeromedical Research Laboratory (USAARL). NR 19 TC 0 Z9 0 U1 0 U2 2 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD MAR PY 2015 VL 180 IS 3 SU S BP 187 EP 190 DI 10.7205/MILMED-D-14-00409 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA CD3OQ UT WOS:000350988500032 PM 25747651 ER PT J AU Bowles, SV Pollock, LD Moore, M Wadsworth, SM Cato, C Dekle, JW Meyer, SW Shriver, A Mueller, B Stephens, M Seidler, DA Sheldon, J Picano, J Finch, W Morales, R Blochberger, S Kleiman, ME Thompson, D Bates, MJ AF Bowles, Stephen V. Pollock, Liz Davenport Moore, Monique Wadsworth, Shelley MacDermid Cato, Colanda Dekle, Judith Ward Meyer, Sonia Wei Shriver, Amber Mueller, Bill Stephens, Mark Seidler, Dustin A. Sheldon, Joseph Picano, James Finch, Wanda Morales, Ricardo Blochberger, Sean Kleiman, Matthew E. Thompson, Daniel Bates, Mark J. TI Total Force Fitness: The Military Family Fitness Model SO MILITARY MEDICINE LA English DT Article ID POSTTRAUMATIC STRESS SYMPTOMS; OPERATION DESERT-STORM; RELATIONSHIP SATISFACTION; EMOTIONAL INTELLIGENCE; CIRCUMPLEX MODEL; SERVICE MEMBERS; PTSD SYMPTOMS; MENTAL-HEALTH; WORK-FAMILY; RESILIENCE AB The military lifestyle can create formidable challenges for military families. This article describes the Military Family Fitness Model (MFFM), a comprehensive model aimed at enhancing family fitness and resilience across the life span. This model is intended for use by Service members, their families, leaders, and health care providers but also has broader applications for all families. The MFFM has three core components: (1) family demands, (2) resources (including individual resources, family resources, and external resources), and (3) family outcomes (including related metrics). The MFFM proposes that resources from the individual, family, and external areas promote fitness, bolster resilience, and foster well-being for the family. The MFFM highlights each resource level for the purpose of improving family fitness and resilience over time. The MFFM both builds on existing family strengths and encourages the development of new family strengths through resource-acquiring behaviors. The purpose of this article is to (1) expand the military's Total Force Fitness (TFF) intent as it relates to families and (2) offer a family fitness model. This article will summarize relevant evidence, provide supportive theory, describe the model, and proffer metrics that support the dimensions of this model. C1 [Bowles, Stephen V.; Blochberger, Sean] Natl Def Univ, Eisenhower Sch, Washington, DC 20319 USA. [Pollock, Liz Davenport] Uniformed Serv Univ Hlth Sci, Dept Mil & Emergency Med, Human Performance Resource Ctr, Bethesda, MD 20814 USA. [Moore, Monique; Cato, Colanda; Finch, Wanda; Bates, Mark J.] Def Ctr Excellence Psychol Hlth, Silver Spring, MD 20910 USA. [Moore, Monique; Cato, Colanda; Finch, Wanda; Bates, Mark J.] Def Ctr Traumat Brain Injury, Silver Spring, MD 20910 USA. [Wadsworth, Shelley MacDermid] Purdue Univ, Mil Family Res Inst, W Lafayette, IN 47907 USA. [Dekle, Judith Ward] Dept Def Mil & Community Family Policy, Washington, DC 20301 USA. [Meyer, Sonia Wei] Beijing Univ Aeronaut & Astronaut, Beijing 100083, Peoples R China. [Shriver, Amber] George Mason Univ, Dept Psychol, Fairfax, VA 22030 USA. [Mueller, Bill] Human Syst Integrat Directorate, Wright Patterson AFB, OH 45433 USA. [Stephens, Mark] Uniformed Serv Univ Hlth Sci, Dept Family Med, Bethesda, MD 20814 USA. [Seidler, Dustin A.] So Illinois Univ, Dept Psychol, Carbondale, IL 62901 USA. [Sheldon, Joseph] Off Religious Affairs J1, Washington, DC 20318 USA. [Picano, James] Northern Calif Hlth Care Syst, Dept Vet Affairs, Martinez, CA 94553 USA. [Morales, Ricardo] US Army Cadet Command, San Antonio, TX 78204 USA. [Kleiman, Matthew E.] US Coast Guard, Behav Hlth Serv Div, Washington, DC 20593 USA. [Thompson, Daniel] Warrior Transit Unit, Ft Bragg, NC 28310 USA. RP Bowles, SV (reprint author), Natl Def Univ, Eisenhower Sch, 408 4th Ave, Washington, DC 20319 USA. NR 114 TC 2 Z9 2 U1 5 U2 9 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD MAR PY 2015 VL 180 IS 3 BP 246 EP 258 DI 10.7205/MILMED-D-13-00416 PG 13 WC Medicine, General & Internal SC General & Internal Medicine GA CD3OI UT WOS:000350987700008 PM 25735013 ER PT J AU Roy, TC Piva, SR Christiansen, BC Lesher, JD Doyle, PM Waring, RM Irrgang, JJ Moore, CG Brininger, TL Sharp, MA AF Roy, Tanja C. Piva, Sara R. Christiansen, Bryan C. Lesher, Jonathan D. Doyle, Peter M. Waring, Rachel M. Irrgang, James J. Moore, Charity G. Brininger, Teresa L. Sharp, Marilyn A. TI Description of Musculoskeletal Injuries Occurring in Female Soldiers Deployed to Afghanistan SO MILITARY MEDICINE LA English DT Article ID LOW-BACK-PAIN; OPERATION IRAQI FREEDOM; BRIGADE COMBAT TEAM; TRAINING-RELATED INJURIES; RISK-FACTORS; ENDURING FREEDOM; US ARMY; PHYSICAL THERAPIST; PROSPECTIVE COHORT; OUTPATIENT VISITS AB Each year musculoskeletal injuries (MSIs) result in thousands of lost duty days and medical discharges. Women represent 15% of the Army and have higher incidence of injury than male soldiers; studies that have investigated MSIs in deployed women are lacking. Therefore, the purpose of this prospective cohort study was to investigate MSIs in women during a 9-month deployment to Afghanistan. Participants were recruited from three Brigade Combat Teams. Participants completed a demographic survey before deployment and a second survey on occupational demands and MSIs after deployment. Of the 160 women, 57 (36%) suffered 78 MSIs resulting in 1,642 days of limited duty, a median of 7 days per MSI, losing 10% of the available duty time to MSIs. Most injuries affected the knee (24%) or low back (18%). Soldiers attributed the majority of injuries (27%) to physical training and trips/falls (17%). Of the MSIs, 93% caused limitations to physical training and 76% resulted in large limitations to occupational tasks. Most MSIs (41%) resolved within 3 weeks and most (37%) occurred before the fourth month of deployment. Prevention measures should target knee and low back injuries. Physical training should be further investigated to discover modifications capable of reducing injuries. C1 [Roy, Tanja C.; Piva, Sara R.; Irrgang, James J.] Univ Pittsburgh, Sch Hlth & Rehabil Sci, Pittsburgh, PA 15260 USA. [Christiansen, Bryan C.] 101st Airborne Div, Airborne Brigade Combat Team 1, Campbell, KY 42223 USA. [Lesher, Jonathan D.; Doyle, Peter M.] 173rd Airborne Brigade Combat Team, APO, AE 09630 USA. [Waring, Rachel M.] 10th Mt Div, Brigade Combat Team 2, Ft Drum, NY 13602 USA. [Moore, Charity G.] Univ Pittsburgh, Ctr Res Hlth Care, Ctr Data, Dept Med,Sch Med, Pittsburgh, PA 15213 USA. [Brininger, Teresa L.] Med Res & Mat Command, Ft Detrick, MD 21702 USA. [Sharp, Marilyn A.] US Army Res Inst Environm Med, Natick, MA 01760 USA. RP Roy, TC (reprint author), Univ Pittsburgh, Sch Hlth & Rehabil Sci, 4028 Forbes Tower, Pittsburgh, PA 15260 USA. FU U.S. Army Medical Research and Materiel Command under Task Area S FX We thank the soldiers from the 173rd Airborne Brigade Combat Team (ABCT); the 1st ABCT, 101st Airborne Division; and the 2nd BCT, 10th Mountain Light Infantry Division for all of their assistance in making this study possible. This research was funded by U.S. Army Medical Research and Materiel Command under Task Area S. NR 53 TC 2 Z9 2 U1 1 U2 4 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD MAR PY 2015 VL 180 IS 3 BP 269 EP 275 DI 10.7205/MILMED-D-14-00365 PG 7 WC Medicine, General & Internal SC General & Internal Medicine GA CD3OI UT WOS:000350987700011 PM 25735016 ER PT J AU Weidlich, CP Ugarriza, DN AF Weidlich, Christopher P. Ugarriza, Doris N. TI A Pilot Study Examining the Impact of Care Provider Support Program on Resiliency, Coping, and Compassion Fatigue in Military Health Care Providers SO MILITARY MEDICINE LA English DT Article ID POSTTRAUMATIC-STRESS-DISORDER; WORK; AFGHANISTAN; DEPRESSION; DEPLOYMENT; VETERANS; IRAQ AB Objectives: The Care Provider Support Program (CPSP) was created as a way to improve the resiliency of military health care providers. The purpose of this pilot study was to update what is currently known about the resiliency, coping, and compassion fatigue of military and civilian registered nurses, licensed practical nurses (LPNs), and medics who treat wounded Soldiers and whether these factors can be improved over a sustained period of time. Methods: A prospective cohort pilot study was implemented to investigate the long-term effects of CPSP training on military and civilian nurses, LPNs, and medics (n = 93) at an Army Medical Center utilizing the Connor-Davidson Resilience Scale, the Ways of Coping Questionnaire, and Professional Quality of Life Questionnaire. Twenty-eight participants returned follow-up questionnaires. Results: CPSP was significant in reducing burnout as measured by the Professional Quality of Life questionnaire, leading to decreased compassion fatigue. CPSP training did not affect resiliency scores on the Connor-Davidson resilience scale or coping scores as measured by the Ways of Coping Questionnaire. Conclusions: on the basis of the results of this study, CPSP training was effective in reducing burnout, which often leads to decreased compassion fatigue in a group of military and civilian registered nurses, LPNs, and medics. C1 [Weidlich, Christopher P.] Joint Base San Antonio, Ctr Nursing Sci & Clin Inquiry, Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. [Ugarriza, Doris N.] Univ Miami, Sch Nursing & Hlth Studies, Coral Gables, FL 33126 USA. RP Weidlich, CP (reprint author), Joint Base San Antonio, Ctr Nursing Sci & Clin Inquiry, Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. FU TriService Nursing Research Program (TSNRP) [HT9404-12-1-TS17] FX We thank Dr. Doris Ugarriza, Dr. Daniel Santisteban, Dr. Karina Gattamorta, Dr. Leigh McGraw, and Ms. Marlene Martin who contributed to this study. Additionally, we thank the TriService Nursing Research Program (TSNRP) for funding this study. TriService Nursing Research Program (TSNRP) grant (HT9404-12-1-TS17) was awarded to the funding of the study. NR 29 TC 3 Z9 3 U1 5 U2 16 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD MAR PY 2015 VL 180 IS 3 BP 290 EP 295 DI 10.7205/MILMED-D-14-00216 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA CD3OI UT WOS:000350987700014 PM 25735019 ER PT J AU Shackelford, SA Fowler, M Schultz, K Summers, A Galvagno, SM Gross, KR Mabry, RL Bailey, JA Kotwal, RS Butler, FK AF Shackelford, Stacy A. Fowler, Marcie Schultz, Keith Summers, Angela Galvagno, Samuel M. Gross, Kirby R. Mabry, Robert L. Bailey, Jeffrey A. Kotwal, Russ S. Butler, Frank K. TI Prehospital Pain Medication Use by U.S. Forces in Afghanistan SO MILITARY MEDICINE LA English DT Article ID COMBAT CASUALTY CARE; POSTTRAUMATIC-STRESS-DISORDER; KETAMINE; MANAGEMENT; TRAUMA; BATTLEFIELD; EXPERIENCE; OPERATIONS; FENTANYL; EFFICACY AB We report the results of a process improvement initiative to examine the current use and safety of prehospital pain medications by U.S. Forces in Afghanistan. Prehospital pain medication data were prospectively collected on 309 casualties evacuated from point of injury (POI) to surgical hospitals from October 2012 to March 2013. Vital signs obtained from POI and flight medics and on arrival to surgical hospitals were compared using one-way analysis of variance test. 119 casualties (39%) received pain medication during POI care and 283 (92%) received pain medication during tactical evacuation (TACEVAC). Morphine and oral transmucosal fentanyl citrate were the most commonly used pain medications during POI care, whereas ketamine and fentanyl predominated during TACEVAC. Ketamine was associated with increase in systolic blood pressure compared to morphine (+7 +/- 17 versus -3 +/- 14 mm Hg, p = 0.04). There was no difference in vital signs on arrival to the hospital between casualties who received no pain medication, morphine, fentanyl, or ketamine during TACEVAC. In this convenience sample, fentanyl and ketamine were as safe as morphine for prehospital use within the dose ranges administered. Future efforts to improve battlefield pain control should focus on improved delivery of pain control at POI and the role of combination therapies. C1 [Shackelford, Stacy A.] Univ Maryland, Med Ctr, Ctr Sustainment Trauma & Readiness Skills, R Adams Cowley Shock Trauma Ctr, Baltimore, MD 21201 USA. [Fowler, Marcie; Gross, Kirby R.; Mabry, Robert L.; Bailey, Jeffrey A.; Kotwal, Russ S.; Butler, Frank K.] US Army Inst Surg Res, Joint Trauma Syst, Ft Sam Houston, TX 78234 USA. [Schultz, Keith] 81 Med Operat Squadron, Keesler AFB, MS 39534 USA. [Summers, Angela] 212 Combat Support Hosp, Miesau Ad, Germany. [Galvagno, Samuel M.] Univ Maryland, Med Ctr, Dept Anesthesiol, Baltimore, MD 21201 USA. RP Shackelford, SA (reprint author), Univ Maryland, Med Ctr, Ctr Sustainment Trauma & Readiness Skills, R Adams Cowley Shock Trauma Ctr, 22 S Greene St, Baltimore, MD 21201 USA. NR 30 TC 2 Z9 2 U1 4 U2 6 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD MAR PY 2015 VL 180 IS 3 BP 304 EP 309 DI 10.7205/MILMED-D-14-00257 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA CD3OI UT WOS:000350987700016 PM 25735021 ER PT J AU Noe, A AF Noe, Adrianne TI The Material Culture of Military Medicine SO MILITARY MEDICINE LA English DT Editorial Material C1 US Army Med Res & Materiel Command, Natl Museum Hlth & Med, Silver Spring, MD 20910 USA. RP Noe, A (reprint author), US Army Med Res & Materiel Command, Natl Museum Hlth & Med, 2500 Linden Lane, Silver Spring, MD 20910 USA. NR 2 TC 0 Z9 0 U1 1 U2 2 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD MAR PY 2015 VL 180 IS 3 BP 361 EP 362 DI 10.7205/MILMED-D-14-00549 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA CD3OI UT WOS:000350987700025 PM 25735030 ER PT J AU Dumayas, GL Capo-Aponte, JE AF Dumayas, Grace Lea Capo-Aponte, Jose E. TI Case Report: Waardenburg Syndrome SO MILITARY MEDICINE LA English DT Article ID SYNDROME TYPE-I; SYNDROME TYPE-2; GENE; DEFINITION; MUTATIONS; ANOMALIES; DIAGNOSIS; DELETIONS; CRITERIA AB Purpose: A case of Waardenburg syndrome type 1 is described and relevant literature is reviewed to raise awareness about this rare syndrome, including the classification of each subtype and the differentiating clinical manifestations. Case Report: A 44-year-old African-American female presented for a routine evaluation with hearing loss, dystopia canthorum (W index = 2.74), and almost complete gray hair. In addition, she presented with heterochromia irides, different fundus pigmentation between eyes. The patient did not have any upper limbs defect, cranial skeletal abnormalities, or intestinal disorders. Conclusion: Facial abnormalities and a white forelock are prominent features difficult to overlook during a routine ophthalmological examination. A careful medical history in patients with suspected Waardenburg syndrome is important to accurately classify this rare condition and to identify potential systemic implications associated to each subtype. The associated systemic complications can be addressed and managed through referral to the appropriate subspecialties. C1 [Dumayas, Grace Lea] Northeastern State Univ Oklahoma, Coll Optometry, Tahlequah, OK 74464 USA. [Capo-Aponte, Jose E.] Womack Army Med Ctr, Dept Optometry, Ft Bragg, NC 28310 USA. RP Dumayas, GL (reprint author), Northeastern State Univ Oklahoma, Coll Optometry, 1001 North Grand Ave, Tahlequah, OK 74464 USA. NR 39 TC 0 Z9 0 U1 1 U2 5 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD MAR PY 2015 VL 180 IS 3 BP E381 EP E387 DI 10.7205/MILMED-D-14-00430 PG 7 WC Medicine, General & Internal SC General & Internal Medicine GA CD3OI UT WOS:000350987700006 PM 25735036 ER PT J AU Plackett, TP Naeem, M AF Plackett, Timothy P. Naeem, Mohammad TI Percutaneous CT-Guided Drainage of a Postoperative Intra-Abdominal Abscess in a Combat Environment SO MILITARY MEDICINE LA English DT Article ID DEEP PELVIC ABSCESSES; IN-VITRO; CATHETERS AB Combat medical care results in limited resource availability, which can prompt creativity in treatment of otherwise common conditions. A postoperative intra-abdominal abscess is not an uncommon occurrence following traumatic hollow viscous injury in the deployed environment, but treatment is often limited to surgical drainage only. Herein, we describe a novel use of a dual-lumen central venous catheter to obtain percutaneous drainage of a postoperative intra-abdominal abscess. C1 [Plackett, Timothy P.] Womack Army Med Ctr, Dept Surg, Ft Bragg, NC 28307 USA. [Naeem, Mohammad] Landstuhl Reg Med Ctr, Dept Radiol, D-66849 Landstuhl, Germany. RP Plackett, TP (reprint author), Womack Army Med Ctr, Dept Surg, 2817 Reilly Rd, Ft Bragg, NC 28307 USA. NR 9 TC 0 Z9 0 U1 0 U2 0 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD MAR PY 2015 VL 180 IS 3 BP E375 EP E377 DI 10.7205/MILMED-D-14-00423 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA CD3OI UT WOS:000350987700004 PM 25735034 ER PT J AU Gillespie, WT AF Gillespie, William T., Jr. TI The Green and the Gray: The Irish in the Confederate States of America SO REVIEWS IN AMERICAN HISTORY LA English DT Book Review C1 [Gillespie, William T., Jr.] US Mil Acad, West Point, NY USA. RP Gillespie, WT (reprint author), Armstrong Atlantic State Univ, Mil Hist World Civilizat & Geog Courses, Savannah, GA 31419 USA. NR 4 TC 0 Z9 0 U1 0 U2 0 PU JOHNS HOPKINS UNIV PRESS PI BALTIMORE PA JOURNALS PUBLISHING DIVISION, 2715 NORTH CHARLES ST, BALTIMORE, MD 21218-4363 USA SN 0048-7511 EI 1080-6628 J9 REV AM HIST JI Rev. Am. Hist. PD MAR PY 2015 VL 43 IS 1 BP 70 EP 76 PG 7 WC History SC History GA CD8EH UT WOS:000351327500015 ER PT J AU Rossi, CA Kearney, BJ Olschner, SP Williams, PL Robinson, CG Heinrich, ML Zovanyi, AM Ingram, MF Norwood, DA Schoepp, RJ AF Rossi, Cynthia A. Kearney, Brian J. Olschner, Scott P. Williams, Priscilla L. Robinson, Camenzind G. Heinrich, Megan L. Zovanyi, Ashley M. Ingram, Michael F. Norwood, David A. Schoepp, Randal J. TI Evaluation of ViroCyt((R)) Virus Counter for Rapid Filovirus Quantitation SO VIRUSES-BASEL LA English DT Article ID TRANSMISSION ELECTRON-MICROSCOPY; EBOLA-VIRUS; QUANTIFICATION; ENUMERATION; INFECTION; DESIGN; ASSAYS AB Development and evaluation of medical countermeasures for diagnostics, vaccines, and therapeutics requires production of standardized, reproducible, and well characterized virus preparations. For filoviruses this includes plaque assay for quantitation of infectious virus, transmission electron microscopy (TEM) for morphology and quantitation of virus particles, and real-time reverse transcription PCR for quantitation of viral RNA (qRT-PCR). The ViroCyt((R)) Virus Counter (VC) 2100 (ViroCyt, Boulder, CO, USA) is a flow-based instrument capable of quantifying virus particles in solution. Using a proprietary combination of fluorescent dyes that stain both nucleic acid and protein in a single 30 min step, rapid, reproducible, and cost-effective quantification of filovirus particles was demonstrated. Using a seed stock of Ebola virus variant Kikwit, the linear range of the instrument was determined to be 2.8E+06 to 1.0E+09 virus particles per mL with coefficient of variation ranging from 9.4% to 31.5% for samples tested in triplicate. VC particle counts for various filovirus stocks were within one log of TEM particle counts. A linear relationship was established between the plaque assay, qRT-PCR, and the VC. VC results significantly correlated with both plaque assay and qRT-PCR. These results demonstrated that the VC is an easy, fast, and consistent method to quantify filoviruses in stock preparations. C1 [Rossi, Cynthia A.; Kearney, Brian J.; Olschner, Scott P.; Williams, Priscilla L.; Heinrich, Megan L.; Zovanyi, Ashley M.; Ingram, Michael F.; Norwood, David A.; Schoepp, Randal J.] US Army Med Res Inst Infect Dis, Diagnost Syst Div, Ft Detrick, MD 21702 USA. [Robinson, Camenzind G.] US Army Med Res Inst Infect Dis, Div Pathol, Ft Detrick, MD 21702 USA. RP Rossi, CA (reprint author), US Army Med Res Inst Infect Dis, Diagnost Syst Div, Ft Detrick, MD 21702 USA. EM cynthia.a.rossi.civ@mail.mil; brian.j.kearney.civ@mail.mil; scott.p.olschner.civ@mail.mil; priscilla.l.williams4.ctr@mail.mil; robinsonc@janelia.hhmi.org; mheinrich7295@gmail.com; azovanyi@gmail.com; michael.f.ingram.mil@mail.mil; david.a.norwood.civ@mail.mil; randal.j.schoepp.civ@mail.mil FU Joint Executive Office; Critical Reagents Program; Medical Countermeasure Systems-Joint Vaccine Acquisition Program [1143605] FX This study was supported by the Joint Executive Office, Critical Reagents Program and Medical Countermeasure Systems-Joint Vaccine Acquisition Program (1143605). NR 22 TC 8 Z9 8 U1 1 U2 2 PU MDPI AG PI BASEL PA POSTFACH, CH-4005 BASEL, SWITZERLAND SN 1999-4915 J9 VIRUSES-BASEL JI Viruses-Basel PD MAR PY 2015 VL 7 IS 3 BP 857 EP 872 DI 10.3390/v7030857 PG 16 WC Virology SC Virology GA CE6JP UT WOS:000351943000001 PM 25710889 ER PT J AU Bebarta, VS Garrett, N Boudreau, S Castaneda, M AF Bebarta, Vikhyat S. Garrett, Normalynn Boudreau, Susan Castaneda, Maria TI A Prospective, Randomized Trial of Intravenous Hydroxocobalamin Versus Whole Blood Transfusion Compared to No Treatment for Class III Hemorrhagic Shock Resuscitation in a Prehospital Swine Model SO ACADEMIC EMERGENCY MEDICINE LA English DT Article ID TRAUMA-ASSOCIATED COAGULOPATHY; PLACEBO-CONTROLLED MULTICENTER; ARGININE HYDROCHLORIDE 546C88; ACUTE CYANIDE TOXICITY; SUS-SCROFA MODEL; NITRIC-OXIDE; FLUID RESUSCITATION; UNCONTROLLED HEMORRHAGE; DOUBLE-BLIND; SODIUM THIOSULFATE AB ObjectivesThe objective was to compare systolic blood pressure (sBP) over time in swine that have had 30% of their blood volume removed (Class III shock) and treated with intravenous (IV) whole blood or IV hydroxocobalamin, compared to nontreated control animals. MethodsThirty swine (45 to 55kg) were anesthetized, intubated, and instrumented with continuous femoral and pulmonary artery pressure monitoring. Animals were hemorrhaged a total of 20 mL/kg over a 20-minute period. Five minutes after hemorrhage, animals were randomly assigned to receive 150 mg/kg IV hydroxocobalamin solubilized in 180 mL of saline, 500 mL of whole blood, or no treatment. Animals were monitored for 60 minutes thereafter. A sample size of 10 animals per group was determined based on a power of 80% and an alpha of 0.05 to detect an effect size of at least a 0.25 difference (>1 standard deviation) in mean sBP between groups. sBP values were analyzed using repeated-measures analysis of variance (RANOVA). Secondary outcome data were analyzed using repeated-measures multivariate analysis of variance (RMANOVA). ResultsThere were no significant differences between hemodynamic parameters of IV hydroxocobalamin versus whole blood versus control group at baseline (MANOVA; Wilks' lambda; p=0.868) or immediately posthemorrhage (mean sBP= 47mm Hg vs. 41mm Hg vs. 37mm Hg; mean arterial pressure= 39mm Hg vs. 28mm Hg vs. 34mm Hg; mean serum lactate= 1.2mmol/L vs. 1.4mmol/L vs. 1.4mmol/L; MANOVA; Wilks' lambda; p=0.348). The outcome RANOVA model detected a significant difference by time between groups (p<0.001). Specifically, 10minutes after treatment, treated animals showed a significant increase in mean sBP compared to nontreated animals (mean sBP= 76.3mm Hg vs. 85.7mm Hg vs. 51.1mm Hg; p<0.001). RMANOVA modeling of the secondary data detected a significant difference in mean arterial pressure, heart rate, and serum lactate (p<0.001). Similar to sBP, 10minutes after treatment, treated animals showed a significant increase in mean arterial pressure compared to nontreated animals (mean arterial pressure= 67.7mm Hg vs. 61.4mm Hg vs. 40.5mm Hg). By 10minutes, mean heart rate was significantly slower in treated animals compared to nontreated animals (mean heart rate= 97.3 beats/min vs. 95.2 beats/min vs. 129.5 beats/min; p<0.05). Serum lactate, an early predictor of shock, continued to rise in the control group, whereas it did not in treated animals. Thirty minutes after treatment, serum lactate values of treated animals were significantly lower compared to nontreated animals (p<0.05). This trend continued throughout the 60-minute observation period such that 60-minute values for lactate were 1.4mmol/L versus 1.1mmol/L versus 3.8mmol/L. IV hydroxocobalamin produced a statistically significant increase in systemic vascular resistance compared to control, but not whole blood, with a concomitant decrease in cardiac output. ConclusionsIntravenous hydroxocobalamin was more effective than no treatment and as effective as whole blood transfusion, in reversing hypotension and inhibiting rises in serum lactate in this prehospital, controlled, Class III swine hemorrhage model. (C) 2015 by the Society for Academic Emergency Medicine C1 [Bebarta, Vikhyat S.; Garrett, Normalynn; Boudreau, Susan; Castaneda, Maria] San Antonio Mil Med Ctr, CREST Res Program, Dept Emergency Med, San Antonio, TX 78234 USA. [Bebarta, Vikhyat S.] US Army, Enroute Care Res Ctr, Inst Surg Res, San Antonio, TX USA. RP Bebarta, VS (reprint author), San Antonio Mil Med Ctr, CREST Res Program, Dept Emergency Med, San Antonio, TX 78234 USA. EM vikbebarta@yahoo.com RI bebarta, vikhyat/K-3476-2015 FU U.S. Air Force Office of the Surgeon General FX The U.S. Air Force Office of the Surgeon General funded this study. No other funding was used. The views expressed in this article are those of the authors and do not reflect the official policy or position of the Department of the U.S. Air Force, Department of Defense, or the U.S. government. The author have no potential conflicts of interest to report. NR 70 TC 0 Z9 0 U1 0 U2 3 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1069-6563 EI 1553-2712 J9 ACAD EMERG MED JI Acad. Emerg. Med. PD MAR PY 2015 VL 22 IS 3 SI SI BP 321 EP 330 DI 10.1111/acem.12605 PG 10 WC Emergency Medicine SC Emergency Medicine GA CD3MA UT WOS:000350981500009 PM 25731610 ER PT J AU Gunay, F Alten, B Simsek, F Aldemir, A Linton, YM AF Gunay, Filiz Alten, Bulent Simsek, Fatih Aldemir, Adnan Linton, Yvonne-Marie TI Barcoding Turkish Culex mosquitoes to facilitate arbovirus vector incrimination studies reveals hidden diversity and new potential vectors SO ACTA TROPICA LA English DT Article DE DNA barcoding; Culex; Arbovirus; Vector; New records; Turkey ID WEST-NILE-VIRUS; ST-LOUIS ENCEPHALITIS; DIPTERA-CULICIDAE; JAPANESE ENCEPHALITIS; VERTICAL TRANSMISSION; MODESTUS FICALBI; SINDBIS VIRUS; GETAH VIRUS; TURKEY; CIRCULATION AB As a precursor to planned arboviral vector incrimination studies, an integrated systematics approach was adopted using morphology and DNA barcoding to examine the Culex fauna present in Turkey. The mitochondrial COI gene (658 bp) were sequenced from 185 specimens collected across 11 Turkish provinces, as well as from colony material. Although by morphology only 9 species were recognised, DNA barcoding recovered 13 distinct species including: Cx. (Barraudius) modestus, Cx. (Culex) laticinctus, Cx. (Cux.) mimeticus, Cx. (Cux.) perexiguus, Cx. (Cux.) pipiens, Cx. (Cux.) pipiens form molestus, Cx. (Cux.) quinquefasciatus, Cx. (Cux.) theilen, Cx. (Cux.) torrentium, Cx. (Cux.) tritaeniorhynchus and Cx. (Maillotia) hortensis. The taxon formerly identified as Cx. (Neoculex) territans was shown to comprise two distinct species, neither of which correspond to Cx. territans s.s. These include Cx. (Neo.) impudicus and another uncertain species, which may be Cx. (Neo.) europaeus or Cx. (Neo.) martinii (herein =Cx. (Neo.) sp. 1). Detailed examination of the Pipiens Group revealed Cx. pipiens, Cx. pipiens f. molestus and the widespread presence of the highly efficient West Nile virus vector Cx. quinquefasciatus for the first time. Four new country records are reported, increasing the Culex of Turkey to 15 recognised species and Cx. pipiens f. molestus. Anew taxonomic checklist is provided, annotated with respective vector competencies for transmission of arboviruses. (C) 2014 The Authors. Published by Elsevier B.V. C1 [Gunay, Filiz; Alten, Bulent] Hacettepe Univ, Fac Sci, Dept Biol, Ecol Sect,ESRL Labs, TR-06800 Beytepe, Turkey. [Simsek, Fatih] Adnan Menderes Univ, Fac Sci & Literature, Dept Biol, Div Ecol, TR-09010 Kepez Aydin, Turkey. [Aldemir, Adnan] Kafkas Univ, Fac Sci & Literature, Dept Biol, TR-36100 Kars, Turkey. [Linton, Yvonne-Marie] Walter Reed Army Inst Res, Entomol Branch, Silver Spring, MD USA. [Linton, Yvonne-Marie] Smithsonian Inst, Museum Support Ctr, Walter Reed Biosystemat Unit, Suitland, MD 20746 USA. [Linton, Yvonne-Marie] Smithsonian Inst, Natl Museum Nat Hist, Dept Entomol, Washington, DC 20560 USA. [Linton, Yvonne-Marie] Uniformed Serv Univ Hlth Sci, Fac Preventat Med & Biometr, Bethesda, MD 20814 USA. RP Linton, YM (reprint author), Walter Reed Army Inst Res, Entomol, Walter Reed Biosystemat Unit, Smithsonian Inst Museum Support Ctr, MRC-534,4210 Silver Hill Rd, Suitland, MD 20746 USA. EM gunayf@gmail.com; kaynas@hacettepe.edu.tr; fsimsek@adu.edu.tr; LintonY@si.edu FU EU SYNTHESYS programme at the Natural History Museum, London; AFHSC-GEIS-Global Emerging Infections Surveillance and Response System, a Division of the Armed Forces Health Surveillance Center [PO327_14_WR]; EU [FP7-261504]; National Research Council (NRC) Research Associateship Award at the Walter Reed Army Institute of Research FX This study forms part of the PhD study of FG, and contributes to the wider objectives of the global Mosquito Barcoding Initiative (MBI), headed by YML and R.C. Wilkerson (Walter Reed Biosystematics Unit). We are thankful to Ms Hilal Bedir for assisting FG and YML in the field in August 2011 and to Dr Berna Demirci (both of Kafkas University, Kars, Turkey) for donations of Culex specimens. Some data reported in this manuscript was generated during a training period for FG funded through the EU SYNTHESYS programme at the Natural History Museum, London, with the remainder generated at the Laboratory of Analytical Biology, Smthsonian Institution, Washington, USA. Data was analysed and prepared for publication while YML, BA and FG held a project grant from AFHSC-GEIS-Global Emerging Infections Surveillance and Response System, a Division of the Armed Forces Health Surveillance Center (Project Grant Award PO327_14_WR to YML). Field studies were supported by EU grant FP7-261504 EDENext and is catalogued by the EDENext Steering Committee as EDENext-269. This manuscript was prepared whilst YML held a National Research Council (NRC) Research Associateship Award at the Walter Reed Army Institute of Research. The material to be published reflects the views of the authors and should not be construed to represent those of the US Department of the Army or the US Department of Defense. NR 83 TC 4 Z9 4 U1 4 U2 14 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0001-706X EI 1873-6254 J9 ACTA TROP JI Acta Trop. PD MAR PY 2015 VL 143 BP 112 EP 120 DI 10.1016/j.actatropica.2014.10.013 PG 9 WC Parasitology; Tropical Medicine SC Parasitology; Tropical Medicine GA CC7DB UT WOS:000350526800016 PM 25446171 ER PT J AU Braun, MM Barstow, CH Pyzocha, NJ AF Braun, Michael M. Barstow, Craig H. Pyzocha, Natasha J. TI Diagnosis and Management of Sodium Disorders: Hyponatremia and Hypernatremia SO AMERICAN FAMILY PHYSICIAN LA English DT Article ID CLINICAL-PRACTICE GUIDELINE; HEART-FAILURE; CARDIAC-SURGERY; TOLVAPTAN; MORTALITY; RISK; ASSOCIATION; ANTAGONIST; MORBIDITY; EXCRETION AB Hyponatremia and hypernatremia are common findings in the inpatient and outpatient settings. Sodium disorders are associated with an increased risk of morbidity and mortality. Plasma osmolality plays a critical role in the pathophysiology and treatment of sodium disorders. Hyponatremia and hypernatremia are classified based on volume status (hypovolemia, euvolemia, and hypervolemia). Sodium disorders are diagnosed by findings from the history, physical examination, laboratory studies, and evaluation of volume status. Treatment is based on symptoms and underlying causes. In general, hyponatremia is treated with fluid restriction (in the setting of euvolemia), isotonic saline (in hypovolemia), and diuresis (in hypervolemia). A combination of these therapies may be needed based on the presentation. Hypertonic saline is used to treat severe symptomatic hyponatremia. Medications such as vaptans may have a role in the treatment of euvolemic and hypervolemic hyponatremia. The treatment of hypernatremia involves correcting the underlying cause and correcting the free water deficit. Copyright (C) 2015 American Academy of Family Physicians. C1 [Braun, Michael M.; Pyzocha, Natasha J.] Madigan Army Med Ctr, Family Med Residency, Tacoma, WA 98431 USA. [Barstow, Craig H.] Womack Army Med Ctr, Family Med Residency, Ft Bragg, NC USA. RP Braun, MM (reprint author), Madigan Army Med Ctr, Family Med Residency, 9040 Fitzsimmons Dr, Tacoma, WA 98431 USA. EM michael.m.braun.civ@mail.mil NR 37 TC 3 Z9 3 U1 3 U2 12 PU AMER ACAD FAMILY PHYSICIANS PI KANSAS CITY PA 8880 WARD PARKWAY, KANSAS CITY, MO 64114-2797 USA SN 0002-838X EI 1532-0650 J9 AM FAM PHYSICIAN JI Am. Fam. Physician PD MAR 1 PY 2015 VL 91 IS 5 BP 299 EP 307 PG 9 WC Primary Health Care; Medicine, General & Internal SC General & Internal Medicine GA CC7HZ UT WOS:000350539600007 PM 25822386 ER PT J AU Soonsawat, A Resident, P Ellison, J Ahmed, I AF Soonsawat, Anothai Resident, Psychiatry Ellison, James Ahmed, Iqbal TI Physician with Cognitive Impairment SO AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY LA English DT Meeting Abstract CT Annual Meeting of the American-Association-for-Geriatric-Psychiatry CY MAR 27-30, 2015 CL New Orleans, LA SP Amer Assoc Geriatr Psychiat C1 [Resident, Psychiatry] Harvard South Shore Psychiat Residency Program, Brockton, MA USA. [Resident, Psychiatry] VA Boston Healthcare Syst, Boston, MA USA. [Ellison, James] McLean Hosp, Belmont, MA 02178 USA. [Ahmed, Iqbal] Tripler Army Med Ctr, Honolulu, HI 96859 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1064-7481 EI 1545-7214 J9 AM J GERIAT PSYCHIAT JI Am. J. Geriatr. Psychiatr. PD MAR PY 2015 VL 23 IS 3 SU S MA EI 66 BP S131 EP S132 PG 3 WC Geriatrics & Gerontology; Gerontology; Psychiatry SC Geriatrics & Gerontology; Psychiatry GA CD1IV UT WOS:000350829500126 ER PT J AU Kragh, JF Nam, JJ Berry, KA Mase, VJ Aden, JK Walters, TJ Dubick, MA Baer, DG Wade, CE Blackbourne, LH AF Kragh, John F. Nam, Jason J. Berry, Keith A. Mase, Vincent J., Jr. Aden, James K., III Walters, Thomas J. Dubick, Michael A. Baer, David G. Wade, Charles E. Blackbourne, Lorne H. TI Transfusion for Shock in US Military War Casualties With and Without Tourniquet Use SO ANNALS OF EMERGENCY MEDICINE LA English DT Article ID MAJOR LIMB TRAUMA; WOUNDS; CARE AB Study objective: We assess whether emergency tourniquet use for transfused war casualties admitted to military hospitals is associated with survival. Methods: A retrospective review of trauma registry data was made of US casualties in Afghanistan and Iraq. Patients with major limb trauma, transfusion, and tourniquet use were compared with similar patients who did not receive tourniquet use. A propensity-matching analysis was performed by stratifying for injury type and severity by tourniquet-use status. Additionally, direct comparison without propensity matching was made between tourniquet use and no-tourniquet use groups. Results: There were 720 casualties in the tourniquet use and 693 in the no-tourniquet use groups. Of the 1,413 casualties, 66%(928) also had nonextremity injury. Casualties with tourniquet use had worse signs of hemorrhagic shock (admission base deficit, admission hemoglobin, admission pulse, and transfusion units required) than those without. Survival rates were similar between the 2 groups (1% difference; 95% confidence interval 2.5% to 4.2%), but casualties who received tourniquets had worse shock and received more blood products. In propensity-matched casualties, survival rates were not different (2% difference; 95% confidence interval 6.7% to 2.7%) between the 2 groups. Conclusion: Tourniquet use was associated with worse shock and more transfusion requirements among hospital-admitted casualties, yet those who received tourniquets had survival rates similar to those of comparable, transfused casualties who did not receive tourniquets. C1 [Kragh, John F.; Dubick, Michael A.] JBSA Ft Sam, Damage Control Resuscitat, Houston, TX 78234 USA. [Aden, James K., III; Walters, Thomas J.; Baer, David G.] JBSA Ft Sam, US Army, Inst Surg Res, Houston, TX USA. [Kragh, John F.] Uniformed Serv Univ Hlth Sci, F Edward Hebert Sch Med, Bethesda, MD 20814 USA. [Nam, Jason J.] Walter Reed Natl Mil Med Ctr, Bethesda, MD USA. [Berry, Keith A.] Penn State Univ, Milton S Hershey Med Ctr, Hershey, PA 17033 USA. [Mase, Vincent J., Jr.] Brian Allgood Army Community Hosp, Seoul, South Korea. [Wade, Charles E.] Univ Texas Houston, Med Sch Houston, Houston, TX USA. [Blackbourne, Lorne H.] JBSA Ft Sam, San Antonio Mil Med Ctr, Houston, TX USA. RP Kragh, JF (reprint author), JBSA Ft Sam, Damage Control Resuscitat, Houston, TX 78234 USA. EM john.f.kragh.civ@mail.mil FU USAISR funds; Defense Health Program [201105] FX By Annals policy, all authors are required to disclose any and all commercial, financial, and other relationships in any way related to the subject of this article as per ICMJE conflict of interest guidelines (see www.icmje.org). This project was funded with internal USAISR funds and the Defense Health Program (proposal 201105). NR 12 TC 12 Z9 12 U1 0 U2 5 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0196-0644 J9 ANN EMERG MED JI Ann. Emerg. Med. PD MAR PY 2015 VL 65 IS 3 BP 290 EP 296 DI 10.1016/j.annemergmed.2014.10.021 PG 7 WC Emergency Medicine SC Emergency Medicine GA CC9QN UT WOS:000350705800013 PM 25458979 ER PT J AU Hammond, RT AF Hammond, Richard T. TI Negative mass SO EUROPEAN JOURNAL OF PHYSICS LA English DT Article DE negative mass; general relativity; string theory ID GENERAL-RELATIVITY; SUPERNOVAE; WORMHOLES; REVERSAL; UNIVERSE AB Some physical aspects of negative mass are examined. Several unusual properties, such as the ability of negative mass to penetrate any armor, are analysed. Other surprising effects include the bizarre system of negative mass chasing positive mass, naked singularities and the violation of cosmic cen-sorship, wormholes, and quantum mechanical results as well. In addition, a brief look into the implications for strings is given. C1 [Hammond, Richard T.] Univ N Carolina, Dept Phys, Chapel Hill, NC 27599 USA. [Hammond, Richard T.] Army Res Off, Res Triangle Pk, NC USA. RP Hammond, RT (reprint author), Univ N Carolina, Dept Phys, Chapel Hill, NC 27599 USA. EM rhammond@email.unc.edu NR 28 TC 0 Z9 0 U1 1 U2 8 PU IOP PUBLISHING LTD PI BRISTOL PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND SN 0143-0807 EI 1361-6404 J9 EUR J PHYS JI Eur. J. Phys. PD MAR PY 2015 VL 36 IS 2 AR 025005 DI 10.1088/0143-0807/36/2/025005 PG 11 WC Education, Scientific Disciplines; Physics, Multidisciplinary SC Education & Educational Research; Physics GA CD1YI UT WOS:000350870200005 ER PT J AU Smith, TJ Hill, KK Xie, G Foley, BT Williamson, CHD Foster, JT Johnson, SL Chertkov, O Teshima, H Gibbons, HS Johnsky, LA Karavis, MA Smith, LA AF Smith, Theresa J. Hill, Karen K. Xie, Gary Foley, Brian T. Williamson, Charles H. D. Foster, Jeffrey T. Johnson, Shannon L. Chertkov, Olga Teshima, Hazuki Gibbons, Henry S. Johnsky, Lauren A. Karavis, Mark A. Smith, Leonard A. TI Genomic sequences of six botulinum neurotoxin-producing strains representing three clostridial species illustrate the mobility and diversity of botulinum neurotoxin genes SO INFECTION GENETICS AND EVOLUTION LA English DT Article DE Clostridium botulinum; Clostridium argentinense; Clostridium baratii; Botulinum neurotoxin ID INFANT BOTULISM; UNITED-STATES; COMPLEX GENES; TOXIN; CLUSTERS; PLASMID; IDENTIFICATION; PERFORMANCE; ANNOTATION; ALGORITHMS AB The whole genomes for six botulinum neurotoxin-producing clostridial strains were sequenced to provide references for under-represented toxin types, bivalent strains or unusual toxin complexes associated with a bont gene. The strains include three Clostridium botulinum Group I strains (CDC 297, CDC 1436, and Prevot 594), a Group II C. botulinum strain (Eklund 202F), a Group IV Clostridium argentinense strain (CDC 2741), and a Group V Clostridium baratii strain (Sullivan). Comparisons of the Group I genomic sequences revealed close relationships and conservation of toxin gene locations with previously published Group I C. botulinum genomes. The bont/F6 gene of strain Eklund 202F was determined to be a chimeric toxin gene composed of bont/F1 and bont/F2. The serotype G strain CDC 2741 remained unfinished in 20 contigs with the bont/G located within a 1.15 Mb contig, indicating a possible chromosomal location for this toxin gene. Within the genome of C. baratii Sullivan strain, direct repeats of IS1182 insertion sequence (IS) elements were identified flanking the bont/F7 toxin complex that may be the mechanism of bont insertion into C. baratii. Highlights of the six strains are described and release of their genomic sequences will allow further study of unusual neurotoxin-producing clostridial strains. Published by Elsevier B.V. C1 [Smith, Theresa J.] US Army Med Res Inst Infect Dis, Mol & Translat Sci Div, Ft Detrick, MD 21702 USA. [Hill, Karen K.; Xie, Gary; Johnson, Shannon L.; Chertkov, Olga; Teshima, Hazuki] Los Alamos Natl Lab, Biosci Div, Los Alamos, NM 87545 USA. [Foley, Brian T.] Los Alamos Natl Lab, Div Theoret, Los Alamos, NM 87545 USA. [Williamson, Charles H. D.; Foster, Jeffrey T.] No Arizona Univ, Ctr Microbial Genet & Genom, Flagstaff, AZ 86011 USA. [Gibbons, Henry S.; Johnsky, Lauren A.; Karavis, Mark A.] Edgewood Chem Biol Ctr, Biosci Div, Aberdeen Proving Ground, MD 21010 USA. [Smith, Leonard A.] US Army Med Res Inst Infect Dis, US Army Med Res & Mat Command, Med Countermeasures Technol, Ft Detrick, MD 21702 USA. RP Smith, TJ (reprint author), US Army Med Res Inst Infect Dis, Mol & Translat Sci Div, 1425 Porter St, Ft Detrick, MD 21702 USA. EM theresa.j.smith.civ@mail.mil OI Foley, Brian/0000-0002-1086-0296; Foster, Jeffrey/0000-0001-8235-8564; xie, gary/0000-0002-9176-924X FU Department of Homeland Security, Science and Technology Directorate; National Institute of Allergy and Infectious Diseases [U01AI056493] FX Funding for this research was provided by the Department of Homeland Security, Science and Technology Directorate and also supported by U01AI056493 from the National Institute of Allergy and Infectious Diseases. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institute of Allergy and Infectious Diseases or the National Institutes of Health. We also thank the Department of Energy Joint Genome Institute for their support in providing technical assistance and facilities for DNA sequencing. Opinions, interpretations, conclusions and recommendations are those of the authors and not necessarily endorsed by the U.S. Army. NR 63 TC 20 Z9 20 U1 1 U2 9 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1567-1348 EI 1567-7257 J9 INFECT GENET EVOL JI Infect. Genet. Evol. PD MAR PY 2015 VL 30 BP 102 EP 113 DI 10.1016/j.meegid.2014.12.002 PG 12 WC Infectious Diseases SC Infectious Diseases GA CC7CN UT WOS:000350525400015 PM 25489752 ER PT J AU Brown, TS Jacob, CG Silva, JC Takala-Harrison, S Djimde, A Dondorp, AM Fukuda, M Noedl, H Nyunt, MM Kyaw, MP Mayxay, M Hien, TT Plowe, CV Cummings, MP AF Brown, Tyler S. Jacob, Christopher G. Silva, Joana C. Takala-Harrison, Shannon Djimde, Abdoulaye Dondorp, Arjen M. Fukuda, Mark Noedl, Harald Nyunt, Myaing Myaing Kyaw, Myat Phone Mayxay, Mayfong Tran Tinh Hien Plowe, Christopher V. Cummings, Michael P. TI Plasmodium falciparum field isolates from areas of repeated emergence of drug resistant malaria show no evidence of hypermutator phenotype SO INFECTION GENETICS AND EVOLUTION LA English DT Article DE Plasmodium falciparum; Drug resistance; Artemisinin; Mutation rate; Molecular evolution ID MUTATIONS; RATES; RECOMBINATION; CLEARANCE; DIVERSITY; ORIGINS; MAMMALS; SPREAD; MAP AB Multiple transcontinental waves of drug resistance in Plasmodium falciparum have originated in Southeast Asia before spreading westward, first into the rest of Asia and then to sub-Saharan Africa. In vitro studies have suggested that hypermutator P. falciparum parasites may exist in Southeast Asia and that an increased rate of acquisition of new mutations in these parasites may explain the repeated emergence of drug resistance in Southeast Asia. This study is the first to test the hypermutator hypothesis using field isolates. Using genome-wide SNP data from human P. falciparum infections in Southeast Asia and West Africa and a test for relative rate differences we found no evidence of increased relative substitution rates in P. falciparum isolates from Southeast Asia. Instead, we found significantly increased substitution rates in Mali and Bangladesh populations relative to those in populations from Southeast Asia. Additionally we found no association between increased relative substitution rates and parasite clearance following treatment with artemisinin derivatives. (C) 2015 Elsevier B.V. All rights reserved. C1 [Djimde, Abdoulaye] Univ Sci Technol & Technol Bamako, Fac Med & Pharmacy, Dept Epidemiol Parasit Dis, Malaria Res & Training Ctr, Bamako, Mali. [Dondorp, Arjen M.] Mahidol Univ, Fac Trop Med, Mahidol Oxford Trop Med Res Unit, Bangkok, Thailand. [Dondorp, Arjen M.] Univ Oxford, Churchill Hosp, Nuffield Dept Med, Ctr Trop Med, Oxford, England. [Brown, Tyler S.; Jacob, Christopher G.; Takala-Harrison, Shannon; Nyunt, Myaing Myaing; Plowe, Christopher V.] Univ Maryland, Sch Med, Howard Hughes Med Inst, Ctr Vaccine Dev, Baltimore, MD 21201 USA. [Noedl, Harald] Med Univ Vienna, Austria & Malaria Res Initiat Bandarban, Inst Specif Prophylaxis & Trop Med, Bandarban, Bangladesh. [Silva, Joana C.] Univ Maryland, Sch Med, Inst Genome Sci, Baltimore, MD 21201 USA. [Silva, Joana C.] Univ Maryland, Sch Med, Dept Microbiol & Immunol, Baltimore, MD 21201 USA. [Mayxay, Mayfong] Mahosot Hosp, Microbiol Lab, Lao Oxford Mahosot Hosp Wellcome Trust Res Unit L, Viangchan, Laos. [Mayxay, Mayfong] Univ Hlth Sci, Fac Postgrad Studies, Viangchan, Laos. [Fukuda, Mark] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Cummings, Michael P.] Univ Maryland, Ctr Bioinformat & Computat Biol, Lab Mol Evolut, College Pk, MD 20742 USA. [Kyaw, Myat Phone] Dept Med Res Lower Myanmar, Yangon, Myanmar. [Tran Tinh Hien] Univ Oxford, Clin Res Unit Vietnam OUCRU, Ctr Trop Med, Ho Chi Minh City, Vietnam. [Brown, Tyler S.] Johns Hopkins Univ, Sch Med, Baltimore, MD USA. RP Cummings, MP (reprint author), Univ Maryland, College Pk, MD 20742 USA. EM mike@umiacs.umd.edu FU National Institute of Allergy and Infectious Diseases [R03AI101680, R01AI101713, U19AI10820]; Howard Hughes Medical Institute FX We thank the Malaria Programme staff at the Wellcome Trust Sanger Institute, including Dominic Kwiatkowski, Olivo Miotto, Bronwyn Maclnnis, Daniel Mead, Eleanor Drury, Susana Campino, Magnus Mankse, and James Stalker, who generated the whole genome sequencing data. In addition, we thank Dr. Timothy O'Connor for his constructive feedback on the manuscript. This work was supported by grants R03AI101680 (C.V.P.) and R01AI101713 (S.T.-H.) and U19AI10820 (J.C.S., C.V.P) from the National Institute of Allergy and Infectious Diseases and by the Howard Hughes Medical Institute. T.S.B. was a Howard Hughes Medical Institute Medical Research Fellow. NR 32 TC 9 Z9 9 U1 1 U2 6 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1567-1348 EI 1567-7257 J9 INFECT GENET EVOL JI Infect. Genet. Evol. PD MAR PY 2015 VL 30 BP 318 EP 322 DI 10.1016/j.meegid.2014.12.010 PG 5 WC Infectious Diseases SC Infectious Diseases GA CC7CN UT WOS:000350525400040 PM 25514047 ER PT J AU Zasowski, E Bland, CM Tam, VH Lodise, TP AF Zasowski, Evan Bland, Christopher M. Tam, Vincent H. Lodise, Thomas P. TI Identification of optimal renal dosage adjustments for high-dose extended-infusion cefepime dosing regimens in hospitalized patients SO JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY LA English DT Article DE antibiotic therapy; Monte Carlo simulations; pharmacodynamics; pharmacokinetics ID BETA-LACTAM ANTIBIOTICS; CRITICALLY-ILL PATIENTS; PSEUDOMONAS-AERUGINOSA; PROLONGED-INFUSION; PHARMACODYNAMICS; PHARMACOKINETICS; INFECTIONS; IMPAIRMENT; MORTALITY AB Objectives: The objective of this study was to identify optimal renal dose adjustments for 2 g of cefepime every 8 h as a 3 h infusion where the probability of target attainment was optimized and drug accumulation was minimal. Methods: Embedded with a population pharmacokinetic model derived in a population of hospitalized patients with varying degrees of renal function, a series of 5000-subject Monte Carlo simulations using ADAPT 5 were performed for 3 h infusions of 2 g every 6, 8, 12 and 24 h. To assess exposure profiles across various levels of renal function, the estimated CLCR was fixed at values between 20 and 150 mL/min. For each regimen examined, the fraction of simulated subjects who achieved free drug concentrations in excess of the MIC for >= 60% of the dosing interval (60% fT>MIC) at the various CLCR levels was determined and this information was used to identify optimal renal dose adjustments without profound drug exposure. Results: In the Monte Carlo simulations, modification of the parent regimen (2 g every 8 h) to 2 g every 6 h for CLCR >120 mL/min and extension of the dosing interval to every 12 and 24 h at CLCR of 60 and 20 mL/min, respectively, provided favourable probability of target attainment profiles without profound drug exposure. Conclusions: The findings from this study identified renal dose alteration regimens that yielded favourable pharmacodynamic profiles without excessive drug exposure. As these findings were based on mathematical models, they should be validated in the clinical arena. C1 [Zasowski, Evan; Lodise, Thomas P.] Albany Coll Pharm & Hlth Sci, Albany, NY 12208 USA. [Bland, Christopher M.] Dwight D Eisenhower Army Med Ctr, Ft Gordon, GA USA. [Tam, Vincent H.] Univ Houston, Coll Pharm, Houston, TX 77030 USA. RP Lodise, TP (reprint author), Albany Coll Pharm & Hlth Sci, Albany, NY 12208 USA. EM thomas.lodise@acphs.edu NR 21 TC 4 Z9 4 U1 1 U2 4 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 0305-7453 EI 1460-2091 J9 J ANTIMICROB CHEMOTH JI J. Antimicrob. Chemother. PD MAR PY 2015 VL 70 IS 3 BP 877 EP 881 DI 10.1093/jac/dku435 PG 5 WC Infectious Diseases; Microbiology; Pharmacology & Pharmacy SC Infectious Diseases; Microbiology; Pharmacology & Pharmacy GA CC2ZV UT WOS:000350214700033 PM 25381169 ER PT J AU Gaydos, SJ Kelley, AM Grandizio, CM Athy, JR Walters, PL AF Gaydos, Steven J. Kelley, Amanda M. Grandizio, Catherine M. Athy, Jeremy R. Walters, P. Lynne TI COMPARISON OF THE EFFECTS OF KETAMINE AND MORPHINE ON PERFORMANCE OF REPRESENTATIVE MILITARY TASKS SO JOURNAL OF EMERGENCY MEDICINE LA English DT Article DE prehospital care; military medicine; soldier skills ID LOW-DOSE KETAMINE; PAIN MANAGEMENT; CARE; OPIOIDS; MEMORY; ADULTS; TRIAL AB Background: When providing care under combat or hostile conditions, it may be necessary for a casualty to remain engaged in military tasks after being wounded. Prehospital care under other remote, austere conditions may be similar, whereby an individual may be forced to continue purposeful actions despite traumatic injury. Given the adverse side-effect profile of intramuscular (i.m.) morphine, alternative analgesics and routes of administration are of interest. Ketamine may be of value in this capacity. Objectives: To delineate performance decrements in basic soldier tasks comparing the effects of the standard battlefield analgesic (10 mg i.m. morphine) with 25 mg i.m. ketamine. Methods: Representative military skills and risk propensity were tested in 48 healthy volunteers without pain stimuli in a double-blind, placebo-controlled, crossover design. Results: Overall, participants reported more symptoms associated with ketamine vs. morphine and placebo, chiefly dizziness, poor concentration, and feelings of happiness. Performance decrements on ketamine, when present, manifested as slower performance times rather than procedural errors. Conclusions: Participants were more symptomatic with ketamine, yet the soldier skills were largely resistant to performance decrements, suggesting that a trained task skill (autonomous phase) remains somewhat resilient to the drugged state at this dosage. The performance decrements with ketamine may represent the subjects' adoption of a cautious posture, as suggested by risk propensity testing whereby the subject is aware of impairment, trading speed for preservation of task accuracy. These results will help to inform the casualty care community regarding appropriate use of ketamine as an alternative or opioid-sparing battlefield analgesic. Published by Elsevier Inc. C1 [Gaydos, Steven J.; Kelley, Amanda M.; Grandizio, Catherine M.; Athy, Jeremy R.; Walters, P. Lynne] US Army Aeromed Res Lab, Ft Rucker, AL 36362 USA. RP Gaydos, SJ (reprint author), US Army Aeromed Res Lab, Warfighter Performance & Hlth Div, 6901 Farrell Rd, Ft Rucker, AL 36362 USA. FU U.S. Army Medical Research and Materiel Command's Combat Casualty Care Research Program; U.S. Army Combat Casualty Care Research Program FX The authors would like to acknowledge the dedication and professionalism of the research staff of the War-fighter Health Division, U.S. Army Aeromedical Research Laboratory, for their contributions to this project. This study was funded by the U.S. Army Medical Research and Materiel Command's Combat Casualty Care Research Program. A detailed technical report of this study is available by contacting the USAARL Science Information Center at 334-255-6907. The study was approved by the U.S. Army Medical Research and Materiel Command Office of Research Protections Institutional Review Board. There are no financial or other relationships that may be perceived as a conflict of interest. This study was sponsored by the U.S. Army Combat Casualty Care Research Program. NR 35 TC 1 Z9 1 U1 1 U2 4 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0736-4679 EI 1090-1280 J9 J EMERG MED JI J. Emerg. Med. PD MAR PY 2015 VL 48 IS 3 BP 313 EP 324 DI 10.1016/j.jemermed.2014.06.047 PG 12 WC Emergency Medicine SC Emergency Medicine GA CC7XH UT WOS:000350581300014 PM 25271185 ER PT J AU Malone, CA AF Malone, Christina A. TI Photographic Analyses Using Skin Detail of the Hand: A Methodology and Evaluation SO JOURNAL OF FORENSIC SCIENCES LA English DT Article DE forensic science; image analysis; photographic comparison; human identification; skin manifestations; skin pigmentation AB Skin features have been employed by law enforcement agencies for suspect and victim identification. Comparisons of hand have arisen in casework where images have been submitted where a face was not present but a hand was visible. This research utilizes a collection of 128 hands from employees of the U.S. Army Criminal Investigation Laboratory to examine the frequency and distribution of skin detail on the dorsal surface of the hand. To assess the location of features, the hand was segmented into 14 regions using readily discernible anatomical landmarks. Overall, 2618 pigmented lesions and 92 scars or injuries were documented. When comparing the regions with one another, Regions 1-10 had fewer pigmented lesions than Regions 11-14. There was no pattern to the distribution of scars throughout the regions. The findings presented a foundation for one possible method that may differentiate hands based on the frequency and distribution of such features. C1 [Malone, Christina A.] US Army, Criminal Invest Lab, Digital Evidence, Def Forens Sci Ctr, Forest Pk, GA 30297 USA. RP Malone, CA (reprint author), US Army, Criminal Invest Lab, Digital Evidence, 4930 N 31st St, Forest Pk, GA 30297 USA. EM christina.a.malone.civ@mail.mil NR 12 TC 3 Z9 3 U1 0 U2 3 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0022-1198 EI 1556-4029 J9 J FORENSIC SCI JI J. Forensic Sci. PD MAR PY 2015 VL 60 IS 2 BP 326 EP 330 DI 10.1111/1556-4029.12670 PG 5 WC Medicine, Legal SC Legal Medicine GA CD0LM UT WOS:000350764300007 PM 25443598 ER PT J AU Pasiakos, SM Lieberman, HR Fulgoni, VL AF Pasiakos, Stefan M. Lieberman, Harris R. Fulgoni, Victor L., III TI Higher-Protein Diets Are Associated with Higher HDL Cholesterol and Lower BMI and Waist Circumference in US Adults SO JOURNAL OF NUTRITION LA English DT Article DE recommended dietary allowance; body mass index; waist circumference; high-density lipoprotein; NHANES ID RANDOMIZED CONTROLLED-TRIALS; LOW-CARBOHYDRATE DIETS; LOW-FAT DIETS; WEIGHT-LOSS; BODY-COMPOSITION; RISK-FACTORS; AMINO-ACIDS; BLOOD-LIPIDS; OBESE ADULTS; WOMEN AB Background: Protein intake above the RDA attenuates cardiometabolic risk in overweight and obese adults during weight loss. However, the cardiometabolic consequences of consuming higher-protein diets in free-living adults have not been determined. Objective: This study examined usual protein intake [g/kg body weight (BW)] patterns stratified by weight status and their associations with cardiometabolic risk using data from the NHANES, 2001-2010 (n = 23,876 adults >= 19 y of age). Methods: Linear and decile trends for association of usual protein intake with cardiometabolic risk factors including blood pressure, glucose, insulin, cholesterol, and triglycerides were determined with use of models that controlled for age, sex, ethnicity, physical activity, poverty-income ratio, energy intake (kcal/d), carbohydrate (g/kg BW) and total fat (g/kg BW) intake, body mass index (BMI), and waist circumference. Results: Usual protein intake varied across deciles from 0.69 +/- 0.004 to 1.51 +/- 0.009 g/kg BW (means +/- SEs). Usual protein intake was inversely associated with BMI (-0.47 kg/m(2) per decile and -4.54 kg/m(2) per g/kg BW) and waist circumference (-0.53 cm per decile and -2.45 cm per g/kg BW), whereas a positive association was observed between protein intake and HDL cholesterol (0.01 mmol/L per decile and 0.14 mmol/L per g/kg BW, P < 0.00125). Conclusions: Americans of all body weights typically consume protein in excess of the RDA. Higher-protein diets are associated with lower BMI and waist circumference and higher HDL cholesterol compared to protein intakes at RDA levels. Our data suggest that Americans who consume dietary protein between 1.0 and 1.5 g/kg BW potentially have a lower risk of developing cardiometabolic disease. C1 [Pasiakos, Stefan M.; Lieberman, Harris R.] US Army Res Inst Environm Med, Mil Nutr Div, Natick, MA 01760 USA. [Fulgoni, Victor L., III] Oak Ridge Inst Sci & Educ, Oak Ridge, TN USA. [Fulgoni, Victor L., III] Nutr Impact LLC, Battle Creek, MI USA. RP Pasiakos, SM (reprint author), US Army Res Inst Environm Med, Mil Nutr Div, Natick, MA 01760 USA. EM stefan.pasiakos@us.army.mil RI Pasiakos, Stefan/E-6295-2014 OI Pasiakos, Stefan/0000-0002-5378-5820 FU US Army Military Research and Materiel Command; Department of Defense Center Alliance for Dietary Supplements Research FX Supported by the US Army Military Research and Materiel Command and the Department of Defense Center Alliance for Dietary Supplements Research. NR 50 TC 5 Z9 5 U1 3 U2 15 PU AMER SOC NUTRITION-ASN PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 0022-3166 EI 1541-6100 J9 J NUTR JI J. Nutr. PD MAR PY 2015 VL 145 IS 3 BP 605 EP 614 DI 10.3945/jn.114.205203 PG 10 WC Nutrition & Dietetics SC Nutrition & Dietetics GA CC5RM UT WOS:000350420400031 PM 25733478 ER PT J AU Hu, SW Choi, J Chan, AL Schwartz, WR AF Hu, Shuowen Choi, Jonghyun Chan, Alex L. Schwartz, William Robson TI Thermal-to-visible face recognition using partial least squares SO JOURNAL OF THE OPTICAL SOCIETY OF AMERICA A-OPTICS IMAGE SCIENCE AND VISION LA English DT Article ID LIGHT IMAGES; IR AB Although visible face recognition has been an active area of research for several decades, cross-modal face recognition has only been explored by the biometrics community relatively recently. Thermal-to-visible face recognition is one of the most difficult cross-modal face recognition challenges, because of the difference in phenomenology between the thermal and visible imaging modalities. We address the cross-modal recognition problem using a partial least squares (PLS) regression-based approach consisting of preprocessing, feature extraction, and PLS model building. The preprocessing and feature extraction stages are designed to reduce the modality gap between the thermal and visible facial signatures, and facilitate the subsequent one-vs-all PLS-based model building. We incorporate multi-modal information into the PLS model building stage to enhance cross-modal recognition. The performance of the proposed recognition algorithm is evaluated on three challenging datasets containing visible and thermal imagery acquired under different experimental scenarios: time-lapse, physical tasks, mental tasks, and subject-to-camera range. These scenarios represent difficult challenges relevant to real-world applications. We demonstrate that the proposed method performs robustly for the examined scenarios. (C) 2015 Optical Society of America C1 [Hu, Shuowen; Chan, Alex L.] US Army Res Lab, Adelphi, MD 20783 USA. [Choi, Jonghyun] Univ Maryland, College Pk, MD 20742 USA. [Schwartz, William Robson] Univ Fed Minas Gerais, BR-31270901 Belo Horizonte, MG, Brazil. RP Hu, SW (reprint author), US Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM shuowen.hu.civ@mail.mil FU Brazilian National Research Council-CNPq [477457/2013-4]; Minas Gerais Research Foundation-FAPEMIG [APQ-01806-13] FX The authors would like to thank the sponsors of this project for their guidance, Dr. Julie Skipper for sharing the WSRI data-set, and Dr. Kenneth Byrd for the NVESD dataset collection effort. W. R. Schwartz would like to thank the Brazilian National Research Council-CNPq (Grant # 477457/2013-4) and the Minas Gerais Research Foundation-FAPEMIG (Grant APQ-01806-13). NR 36 TC 14 Z9 14 U1 2 U2 7 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1084-7529 EI 1520-8532 J9 J OPT SOC AM A JI J. Opt. Soc. Am. A-Opt. Image Sci. Vis. PD MAR 1 PY 2015 VL 32 IS 3 BP 431 EP 442 DI 10.1364/JOSAA.32.000431 PG 12 WC Optics SC Optics GA CC9BP UT WOS:000350662800010 PM 26366654 ER PT J AU Proffitt, A Faulconer, R Kreishman, P Graybill, S Craig, D AF Proffitt, Adrian Faulconer, R. Kreishman, P. Graybill, S. Craig, D. TI An unusual cause of peritonitis in a deployed environment SO JOURNAL OF THE ROYAL ARMY MEDICAL CORPS LA English DT Article ID FAMILIAL MEDITERRANEAN FEVER; PREVALENCE AB Acute abdominal pain is a common presenting complaint to both primary and secondary care, and is a frequent cause of hospital admission among deployed personnel. Identification of generalised peritonism on abdominal examination is a classical indicator of intra-abdominal pathology that may warrant exploratory laparotomy. Negative findings at laparotomy should serve as a diagnostic prompt to consider other non-surgical mimics of an acute abdomen. C1 [Proffitt, Adrian] Univ Hosp North Staffordshire, Dept Med, Acute Internal Med ST3, Stoke On Trent ST4 6QG, Staffs, England. [Faulconer, R.] Russells Hall Hosp, Dept Surg, Gen & Vasc Surg ST5, Dudley, W Midlands, England. [Kreishman, P.] Womack Mil Med Ctr, Dept Surg, Ft Bragg, NC USA. [Graybill, S.] San Antonio Mil Med Ctr, Dept Internal Med, Ft Sam Houston, TX USA. [Craig, D.] James Cook Univ Hosp, Dept Gastroenterol, Middlesbrough, N Yorkshire, England. RP Proffitt, A (reprint author), Univ Hosp North Staffordshire, Dept Med, Stoke On Trent ST4 6QG, Staffs, England. EM adrianproffitt@doctors.org.uk NR 9 TC 0 Z9 0 U1 0 U2 0 PU BMJ PUBLISHING GROUP PI LONDON PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND SN 0035-8665 EI 2052-0468 J9 J ROY ARMY MED CORPS JI J. R. Army Med. Corps PD MAR PY 2015 VL 161 IS 1 BP 69 EP 70 DI 10.1136/jramc-2013-000185 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA CC7VB UT WOS:000350575400016 PM 24254746 ER PT J AU Kim, SW Melby, JA Nadal-Caraballo, NC Ratcliff, J AF Kim, Seung-Woo Melby, Jeffrey A. Nadal-Caraballo, Norberto C. Ratcliff, Jay TI A time-dependent surrogate model for storm surge prediction based on an artificial neural network using high-fidelity synthetic hurricane modeling SO NATURAL HAZARDS LA English DT Article DE Time-dependent surrogate model; Artificial neural network; Storm surge; High-fidelity model ID SEA-LEVEL VARIATIONS; SWAN PLUS ADCIRC; WAVE; HARBOR AB Expedient prediction of storm surge is required for emergency managers to make critical decisions for evacuation, structure closure, and other emergency responses. However, time-dependent storm surge models do not exist for fast and accurate prediction in very short periods on the order of seconds to minutes. In this paper, a time-dependent surrogate model of storm surge is developed based on an artificial neural network with synthetic simulations of hurricanes. The neural network between six input hurricane parameters and one target parameter, storm surge, is trained by a feedforward backpropagation algorithm at each of 92 uniform time steps spanning 45.5 h for each storm. The basis data consist of 446 tropical storms developed from a joint probability model that was based on historical tropical storm activity in the Gulf of Mexico. Each of the 446 storms was modeled at high fidelity using a coupled storm surge and nearshore wave model. Storm surge is predicted by the 92 trained networks for approaching hurricane climatological and track parameters in a few seconds. Furthermore, the developed surrogate model is validated with measured data and high-fidelity simulations of two historical hurricanes at four points in southern Louisiana. In general, the neural networks at or near the boundary between land and ocean are well trained and model predictions are of similar accuracy to the basis modeling suites. Networks based on modeling results from complex inland locations are relatively poorly trained. C1 [Kim, Seung-Woo] Dynam Solut LLC, Hydraul & Hydrodynam Grp, Knoxville, TN 37919 USA. [Melby, Jeffrey A.; Nadal-Caraballo, Norberto C.; Ratcliff, Jay] US Army Engineer Res & Dev Ctr, Coastal & Hydraul Lab, Vicksburg, MS 39180 USA. RP Melby, JA (reprint author), US Army Engineer Res & Dev Ctr, Coastal & Hydraul Lab, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM jeffrey.a.melby@usace.army.mil FU US Army Corps of Engineers, Engineer Research and Development Center, Coastal and Hydraulics Laboratory; National Research Foundation of Korea (NRF) - Ministry of Education, Science and Technology [2012R1A6A3A03038355] FX This work was done under contract with the US Army Corps of Engineers, Engineer Research and Development Center, Coastal and Hydraulics Laboratory and was also supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (No. 2012R1A6A3A03038355). In particular, the contribution of Prof. Casey Dietrich in providing the high-fidelity simulations and precious comments is greatly appreciated. NR 39 TC 1 Z9 1 U1 2 U2 7 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0921-030X EI 1573-0840 J9 NAT HAZARDS JI Nat. Hazards PD MAR PY 2015 VL 76 IS 1 BP 565 EP 585 DI 10.1007/s11069-014-1508-6 PG 21 WC Geosciences, Multidisciplinary; Meteorology & Atmospheric Sciences; Water Resources SC Geology; Meteorology & Atmospheric Sciences; Water Resources GA CC4LZ UT WOS:000350326200029 ER PT J AU Heimann, DC Morris, DM Gemeinhardt, TR AF Heimann, D. C. Morris, D. M. Gemeinhardt, T. R. TI NUTRIENT CONTRIBUTIONS FROM ALLUVIAL SOILS ASSOCIATED WITH THE RESTORATION OF SHALLOW WATER HABITAT IN THE LOWER MISSOURI RIVER SO RIVER RESEARCH AND APPLICATIONS LA English DT Article DE shallow water habitat; side-channel chutes; Missouri River; river restoration; alluvial soils ID MISSISSIPPI RIVER; DAM REMOVAL; LOUISIANA; HYPOXIA AB The Missouri River has been extensively altered as the result of channelization, bank stabilization, and the construction of six main stem reservoirs. In response to the resultant habitat loss, the US Army Corps of Engineers was tasked with restoring approximately 8100ha of shallow water habitat (SWH), in part, for the benefit of the endangered pallid sturgeon (Scaphirhynchus albus). Construction of off-channel habitats involves the removal and disposal of excavated alluvium either by direct discharge into the river or by secondary erosion, which raised concerns regarding the introduction of sediment and associated nutrients into the Missouri River. Soils from nine side-channel chutes were sampled to represent nutrient concentrations from habitat restoration activities. Soils from 12 historically undisturbed sites were also sampled to represent reference conditions in the Missouri River flood plain. The results of this study indicate that nutrient characteristics of soils from selected SWH locations generally are similar to those of historically undisturbed soils. The estimated mass of total phosphorus from chutes accounted for 1.9% of Missouri River and 0.5% of Mississippi River total phosphorus loads during the 1993-2012 analysis period. The mass of nitrate, the constituent most closely related to gulf hypoxia, was 0.01% or less of the Missouri and Mississippi River nitrate loads. Sediment volumes from the chutes accounted for 3.1 and 1.5% of total suspended loads from the Missouri and Mississippi Rivers. Overall, the introduced sediment from side-channel chute construction associated with SWH restoration accounts for a small portion of total nutrient and sediment transport in the Missouri and Mississippi Rivers. Published 2014. This article is a U.S. Government work and is in the public domain in the USA. River Research and Applications published by John Wiley & Sons, Ltd. C1 [Heimann, D. C.] US Geol Survey, Lees Summit, MO USA. [Morris, D. M.; Gemeinhardt, T. R.] US Army Corps Engineers, Missouri River Water Qual Program, Kansas City, MO 64106 USA. RP Morris, DM (reprint author), US Army Corps Engineers, Missouri River Water Qual Program, Kansas City, MO 64106 USA. EM dane.m.morris@usace.army.mil FU USACE, Kansas City District FX This study was conducted with a financial support from the USACE, Kansas City District. We would like to thank the Kansas City District Drill Crew and Palmerton & Parrish, Inc. for their valuable help in collecting soil samples. For GIS analyses, orthophotograph analyses, and bathymetric survey data collection, the authors gratefully acknowledge Tracy Brown, Lisa Hook, Shahrzad Jalili, and Ben Johnson (USACE). Finally, for providing a technical review of the report, the authors gratefully acknowledge Chance Bitner (USACE) and Kyle Juracek (USGS). Reference to trade names does not imply endorsement by the US Government. All product names and trademarks cited are the property of their respective owners. The findings of this report are not to be construed as an official Department of Army position unless so designated by other authorized documents. NR 44 TC 1 Z9 1 U1 3 U2 10 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1535-1459 EI 1535-1467 J9 RIVER RES APPL JI River Res. Appl. PD MAR PY 2015 VL 31 IS 3 BP 323 EP 334 DI 10.1002/rra.2742 PG 12 WC Environmental Sciences; Water Resources SC Environmental Sciences & Ecology; Water Resources GA CD4LQ UT WOS:000351054600006 ER PT J AU Hickey, JT Newbold, SJ Warner, AT AF Hickey, J. T. Newbold, S. J. Warner, A. T. TI HEC-RPT - SOFTWARE FOR FACILITATING DEVELOPMENT OF RIVER MANAGEMENT ALTERNATIVES SO RIVER RESEARCH AND APPLICATIONS LA English DT Article DE HEC-RPT; Regime Prescription Tool; water resources planning; collaborative modelling; environmental flows ID WATER MANAGEMENT; SYSTEM AB The Regime Prescription Tool (RPT) is a software program designed to help groups of scientists, engineers, and water managers access hydrologic data and draft flow recommendations while formulating different ways to manage rivers. It is a communications tool and contributes in the early stages of planning by formalizing ideas and expert knowledge into a structure easily visualized and considered in more detailed analytical tools. Applying RPT helps organize and focus group conversations that seek to create consensus-based alternatives for water management. This paper introduces the software and its role in water resources planning. An RPT application used in the definition of environmental flows for the McKenzie River, Oregon, USA, is presented. Copyright (c) 2014 John Wiley & Sons, Ltd. C1 [Hickey, J. T.] USACE, Hydrol Engn Ctr, Inst Water Resources, Davis, CA 95616 USA. [Newbold, S. J.] Resource Management Associates, Fairfield, CA USA. [Warner, A. T.] Nature Conservancy, North Amer Freshwater Program, University Pk, PA USA. RP Hickey, JT (reprint author), USACE, Hydrol Engn Ctr, Inst Water Resources, 609 Second St, Davis, CA 95616 USA. EM john.t.hickey@usace.army.mil FU cooperative of Corps District offices FX Development of RPT was initially partnered by The Nature Conservancy, and the Portland District and HEC of the US Army Corps of Engineers. Mary Karen Scullion, Brad Bird, and Bruce Duffe, Portland District, were instrumental in commencing this project. Since then, RPT has been supported through a model maintenance programme sponsored by a cooperative of Corps District offices. The Nature Conservancy (www.nature.org) contributed to design and has led several applications of RPT. Software coding was performed by Resource Management Associates, Inc. (www.rmanet.com). The McKenzie River Environmental Flows Workshop was led by Leslie Bach, The Nature Conservancy, Karl Morgenstern, Eugene Water and Electric Board, and John Risley, USGS. Application of RPT was prepared and conducted by John Risley. NR 32 TC 1 Z9 1 U1 0 U2 4 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1535-1459 EI 1535-1467 J9 RIVER RES APPL JI River Res. Appl. PD MAR PY 2015 VL 31 IS 3 BP 392 EP 401 DI 10.1002/rra.2745 PG 10 WC Environmental Sciences; Water Resources SC Environmental Sciences & Ecology; Water Resources GA CD4LQ UT WOS:000351054600011 ER PT J AU Svensson, SP Crowne, FJ Hier, HS Sarney, WL Beck, WA Lin, Y Donetsky, D Suchalkin, S Belenky, G AF Svensson, S. P. Crowne, F. J. Hier, H. S. Sarney, W. L. Beck, W. A. Lin, Y. Donetsky, D. Suchalkin, S. Belenky, G. TI Background and interface electron populations in InAs0.58Sb0.42 SO SEMICONDUCTOR SCIENCE AND TECHNOLOGY LA English DT Article DE InAsSb; Hall-effect; doping ID TRANSPORT-PROPERTIES; QUANTUM-WELLS; PHOTODIODES; SURFACES; DONORS AB The unintentional background electron population and associated interface and surface conductivity in a heterostructure of InAs0.58Sb0.42 with a bandgap of 0.144 eV and AlInSb was studied with multi-carrier Hall-effect analysis. A free electron bulk concentration at 77 K was found with a density of 2.4 x 10(15) cm(-3) and mobility of 140 000 cm(2) V(-1)s(-1). A surface electron accumulation layer was observed with a density of 5.5 x 10(11) cm(-2) and mobility of 4500 cm(2)V(-1)s(-1) that is consistent with predictions of surface Fermi level pinning. Another accumulation layer was identified at the interface with the AlInSb of 4 x 10(11) cm(-2) with a mobility of 37 000 cm(2) V(-1)s(-1). The origin of the defects and the implications for device structures are discussed. C1 [Svensson, S. P.; Crowne, F. J.; Hier, H. S.; Sarney, W. L.; Beck, W. A.] US Army, Res Lab, Adelphi, MD 20783 USA. [Lin, Y.; Donetsky, D.; Suchalkin, S.; Belenky, G.] SUNY Stony Brook, Dept Elect & Comp Engn, Stony Brook, NY 11794 USA. RP Svensson, SP (reprint author), US Army, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM stefan.p.svensson.civ@mail.mil OI LIN, YOUXI/0000-0002-9092-2302 FU US Army Research Office [W911NF1220057]; US National Science Foundation [DMR1160843] FX Part of this work was supported by the US Army Research Office through award W911NF1220057 and by the US National Science Foundation through grant DMR1160843. NR 26 TC 4 Z9 4 U1 5 U2 19 PU IOP PUBLISHING LTD PI BRISTOL PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND SN 0268-1242 EI 1361-6641 J9 SEMICOND SCI TECH JI Semicond. Sci. Technol. PD MAR PY 2015 VL 30 IS 3 AR 035018 DI 10.1088/0268-1242/30/3/035018 PG 5 WC Engineering, Electrical & Electronic; Materials Science, Multidisciplinary; Physics, Condensed Matter SC Engineering; Materials Science; Physics GA CC8PU UT WOS:000350631400019 ER PT J AU Srinivas, U Nasrabadi, NM Monga, V AF Srinivas, Umamahesh Nasrabadi, Nasser M. Monga, Vishal TI Graph-Based Sensor Fusion for Classification of Transient Acoustic Signals SO IEEE TRANSACTIONS ON CYBERNETICS LA English DT Article DE Acoustic signal classification; discriminative graphs; multiple measurements; symbolic features ID SUPPORT VECTOR MACHINES; MULTISENSOR DATA FUSION; DISTRIBUTIONS; RECOGNITION; RETRIEVAL; NETWORKS; MODELS AB Advances in acoustic sensing have enabled the simultaneous acquisition of multiple measurements of the same physical event via co-located acoustic sensors. We exploit the inherent correlation among such multiple measurements for acoustic signal classification, to identify the launch/impact of munition (i.e., rockets, mortars). Specifically, we propose a probabilistic graphical model framework that can explicitly learn the class conditional correlations between the cepstral features extracted from these different measurements. Additionally, we employ symbolic dynamic filtering-based features, which offer improvements over the traditional cepstral features in terms of robustness to signal distortions. Experiments on real acoustic data sets show that our proposed algorithm outperforms conventional classifiers as well as the recently proposed joint sparsity models for multisensor acoustic classification. Additionally our proposed algorithm is less sensitive to insufficiency in training samples compared to competing approaches. C1 [Srinivas, Umamahesh; Monga, Vishal] Penn State Univ, Dept Elect Engn, University Pk, PA 16802 USA. [Nasrabadi, Nasser M.] US Army Res Lab, Adelphi, MD 20783 USA. RP Srinivas, U (reprint author), Penn State Univ, Dept Elect Engn, University Pk, PA 16802 USA. EM usrinivas@ieee.org; vmonga@engr.psu.edu FU Office of Naval Research [N00014-12-1-0765] FX The work of U. Srinivas and V. Monga was supported by the Office of Naval Research under Grant N00014-12-1-0765. NR 39 TC 1 Z9 1 U1 0 U2 5 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 2168-2267 EI 2168-2275 J9 IEEE T CYBERNETICS JI IEEE T. Cybern. PD MAR PY 2015 VL 45 IS 3 BP 576 EP 587 DI 10.1109/TCYB.2014.2331284 PG 12 WC Computer Science, Artificial Intelligence; Computer Science, Cybernetics SC Computer Science GA CC2AN UT WOS:000350146900019 PM 25014986 ER PT J AU Darwish, A Bayba, AJ Hung, HA AF Darwish, Ali Bayba, Andrew J. Hung, Hingloi Alfred TI Channel Temperature Analysis of GaN HEMTs With Nonlinear Thermal Conductivity SO IEEE TRANSACTIONS ON ELECTRON DEVICES LA English DT Article DE AlGaN; gallium nitride (GaN); HEMT; nonlinear thermal conductivity; reliability; thermal resistance; wide bandgap ID ALGAN/GAN HEMTS; BOUNDARY RESISTANCE; THIN-FILMS; DEVICES; TRANSISTORS; MICROSCOPY; SUBSTRATE; GANHEMTS; CRYSTALS AB This paper presents an enhanced, closed-form expression for the thermal resistance, and thus, the channel temperature of AlGaN/gallium nitride (GaN) HEMTs, including the effect of the temperature-dependent thermal conductivity of GaN and SiC or Si substrates. In addition, the expression accounts for temperature increase across the die-attach. The model's validity is verified by comparing it with experimental observations. The model results also compare favorably with those from finite-element numerical simulations across the various device geometric and material parameters. The model provides a more accurate channel temperature than that from a constant thermal conductivity assumption; this is particularly significant for GaN/Si HEMTs where the temperature rise is higher than in GaN/SiC. The model is especially useful for device and monolithic microwave integrated circuit designers in the thermal assessment of their device design iterations against required performance for their specific applications. C1 [Darwish, Ali; Bayba, Andrew J.; Hung, Hingloi Alfred] US Army Res Lab, Adelphi, MD 20783 USA. RP Darwish, A (reprint author), US Army Res Lab, Adelphi, MD 20783 USA. EM darwish@alum.mit.edu; andrew.j.bayba.civ@mail.mil; hahung@alum.mit.edu NR 37 TC 9 Z9 9 U1 7 U2 45 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0018-9383 EI 1557-9646 J9 IEEE T ELECTRON DEV JI IEEE Trans. Electron Devices PD MAR PY 2015 VL 62 IS 3 BP 840 EP 846 DI 10.1109/TED.2015.2396035 PG 7 WC Engineering, Electrical & Electronic; Physics, Applied SC Engineering; Physics GA CC4OF UT WOS:000350332000023 ER PT J AU D'Onofrio, MJ Schlett, CD Millar, EV Cui, T Lanier, JB Law, NN Tribble, DR Ellis, MW AF D'Onofrio, Michael J. Schlett, Carey D. Millar, Eugene V. Cui, Tianyuan Lanier, Jeffrey B. Law, Natasha N. Tribble, David R. Ellis, Michael W. TI Reduction in Acute Gastroenteritis among Military Trainees: Secondary Effects of a Hygiene-based Cluster-Randomized Trial for Skin and Soft Tissue Infection Prevention SO INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY LA English DT Editorial Material C1 [D'Onofrio, Michael J.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Schlett, Carey D.; Millar, Eugene V.; Cui, Tianyuan; Law, Natasha N.; Tribble, David R.] Uniformed Serv Univ Hlth Sci, Infect Dis Clin Res Program, Bethesda, MD 20814 USA. [Lanier, Jeffrey B.] Martin Army Community Hosp, Ft Benning, GA USA. [Ellis, Michael W.] Uniformed Serv Univ Hlth Sci, Dept Med, Bethesda, MD 20814 USA. RP Millar, EV (reprint author), Uniformed Serv Univ Hlth Sci, Infect Dis Clin Res Program, Dept Prevent Med & Biometr, 11300 Rockville Pike,Suite 1211, Rockville, MD 20852 USA. EM emillar@idcrp.org FU NIAID NIH HHS [Y1-AI-5072]] NR 6 TC 1 Z9 1 U1 0 U2 0 PU CAMBRIDGE UNIV PRESS PI NEW YORK PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA SN 0899-823X EI 1559-6834 J9 INFECT CONT HOSP EP JI Infect. Control Hosp. Epidemiol. PD MAR PY 2015 VL 36 IS 3 BP 358 EP 360 DI 10.1017/ice.2014.65 PG 3 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA CC2DW UT WOS:000350156300019 PM 25695181 ER PT J AU Kittikraisak, W Suntarattiwong, P Levy, J Fernandez, S Dawood, FS Olsen, SJ Chotpitayasunondh, T AF Kittikraisak, Wanitchaya Suntarattiwong, Piyarat Levy, Jens Fernandez, Stefan Dawood, Fatimah S. Olsen, Sonja J. Chotpitayasunondh, Tawee TI Influenza vaccination coverage and effectiveness in young children in Thailand, 2011-2013 SO INFLUENZA AND OTHER RESPIRATORY VIRUSES LA English DT Article DE Influenza; vaccination; coverage; effectiveness; Thailand; children ID AGED 6-23 MONTHS; LABORATORY-CONFIRMED INFLUENZA; UNITED-STATES; SEASON; IMMUNIZATION; EFFICACY; HOSPITALIZATION; OUTPATIENT; COMMUNITY; VACCINES AB BackgroundSince 2009, Thailand has recommended influenza vaccine for children aged 6months through 2years, but no estimates of influenza vaccine coverage or effectiveness are available for this target group. MethodsDuring August 2011-May 2013, high-risk and healthy children aged 36months were enrolled in a 2-year prospective cohort study. Parents were contacted weekly about acute respiratory illness (ARI) in their child. Ill children had combined nasal and throat swabs tested for influenza viruses by real-time reverse transcription-polymerase chain reaction. Influenza vaccination status was verified with vaccination cards. The Cox proportional hazards approach was used to estimate hazard ratios. Vaccine effectiveness (VE) was estimated as 100% x (1-hazard ratio). ResultsDuring 2011-2013, 968 children were enrolled (median age, 103months); 948 (979%) had a vaccination record and were included. Of these, 394 (416%) had 1 medical conditions. Vaccination coverage for the 2011-2012 and 2012-2013 seasons was 293% (93/317) and 300% (197/656), respectively. In 2011-2012, there were 213 ARI episodes, of which 10 (46%) were influenza positive (23 per 1000 vaccinated and 38 per 1000 unvaccinated child-weeks). The VE was 55% (95% confidence interval [CI], -72, 88). In 2012-2013, there were 846 ARIs, of which 52 (62%) were influenza positive (18 per 1000 vaccinated and 45 per 1000 unvaccinated child-weeks). The VE was 64% (CI, 13%, 85%). ConclusionInfluenza vaccination coverage among young children in Thailand was low, although vaccination was moderately effective. Continued efforts are needed to increase influenza vaccination coverage and evaluate VE among young children in Thailand. C1 [Kittikraisak, Wanitchaya; Levy, Jens; Olsen, Sonja J.] Thailand Minist Publ Hlth US Ctr Dis Control & Pr, Influenza Program, Nonthaburi, Thailand. [Suntarattiwong, Piyarat; Chotpitayasunondh, Tawee] Minist Publ Hlth, Queen Sirikit Natl Inst Child Hlth, Bangkok, Thailand. [Fernandez, Stefan] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Dawood, Fatimah S.; Olsen, Sonja J.] US Ctr Dis Control & Prevent, Influenza Div, Atlanta, GA USA. RP Kittikraisak, W (reprint author), Minist Publ Hlth, Thailand MOPH US CDC Collaborat, DDC Bldg 7,Tiwanon Rd, Nonthaburi 11000, Thailand. EM glr9@cdc.gov FU U.S. Centers for Disease Control and Prevention [5U01GH000152] FX This project was funded by U.S. Centers for Disease Control and Prevention through cooperative agreement 5U01GH000152. All authors have no financial relationships relevant to this article to disclose. NR 43 TC 6 Z9 6 U1 2 U2 3 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1750-2640 EI 1750-2659 J9 INFLUENZA OTHER RESP JI Influenza Other Respir. Viruses PD MAR PY 2015 VL 9 IS 2 BP 85 EP 93 DI 10.1111/irv.12302 PG 9 WC Infectious Diseases; Virology SC Infectious Diseases; Virology GA CC4TQ UT WOS:000350347100005 PM 25557920 ER PT J AU Ivany, CG Hoge, CW AF Ivany, Christopher G. Hoge, Charles W. TI Adverse Childhood Experiences and Military Service SO JAMA PSYCHIATRY LA English DT Letter C1 [Ivany, Christopher G.; Hoge, Charles W.] Behav Hlth Div, Off Army Surg Gen, Falls Church, VA USA. [Hoge, Charles W.] Walter Reed Army Inst Res, Ctr Psychiat & Neurosci, Silver Spring, MD 20910 USA. RP Hoge, CW (reprint author), Walter Reed Army Inst Res, Ctr Psychiat & Neurosci, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM charles.hoge@us.army.mil NR 5 TC 2 Z9 2 U1 0 U2 1 PU AMER MEDICAL ASSOC PI CHICAGO PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA SN 2168-622X EI 2168-6238 J9 JAMA PSYCHIAT JI JAMA Psychiatry PD MAR PY 2015 VL 72 IS 3 BP 296 EP 296 PG 1 WC Psychiatry SC Psychiatry GA CC7UJ UT WOS:000350573600015 PM 25738692 ER PT J AU Jelis, E Clemente, M Kerwien, S Ravindra, NM Hespos, MR AF Jelis, Elias Clemente, Matthew Kerwien, Stacey Ravindra, Nuggehalli M. Hespos, Michael R. TI Metallurgical and Mechanical Evaluation of 4340 Steel Produced by Direct Metal Laser Sintering SO JOM LA English DT Article ID MICROSTRUCTURAL FEATURES; FATIGUE BEHAVIOR; POWDERS; ALLOY AB Direct metal laser sintering (DMLS) was used to produce high-strength low-alloy 4340 steel specimens. Mechanical and metallurgical analyses were performed on the specimens to determine the samples with the highest strengths and the least porosity. The optimal process parameters were thus defined based on the corresponding experimental conditions. Additionally, the effects of fabricating specimens with both virgin and recycled powders were studied. Scanning electron microscopy and electron-dispersive spectroscopy were performed on both types of powders to determine the starting morphology and composition. The initial tensile results are promising, suggesting that DMLS can produce specimens equal in strength to wrought materials. However, there is evidence of cracking on several of the heat-treated tensile specimens that is unexplained. Several theories point to disturbances in the build chamber environment that went undetected while the specimens were being fabricated. C1 [Jelis, Elias; Clemente, Matthew; Kerwien, Stacey; Hespos, Michael R.] US Army ARDEC, Picatinny Arsenal, NJ 07806 USA. [Jelis, Elias; Ravindra, Nuggehalli M.] New Jersey Inst Technol, Interdisciplinary Program Mat Sci & Engn, Newark, NJ 07102 USA. RP Jelis, E (reprint author), US Army ARDEC, Picatinny Arsenal, NJ 07806 USA. EM nmravindra@gmail.com FU SMART Fellowship by US Department of Defense FX Elias Jelis acknowledges with thanks the award of the SMART Fellowship by the US Department of Defense. NR 28 TC 5 Z9 5 U1 4 U2 16 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1047-4838 EI 1543-1851 J9 JOM-US JI JOM PD MAR PY 2015 VL 67 IS 3 BP 582 EP 589 DI 10.1007/s11837-014-1273-8 PG 8 WC Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering; Mineralogy; Mining & Mineral Processing SC Materials Science; Metallurgy & Metallurgical Engineering; Mineralogy; Mining & Mineral Processing GA CC3ID UT WOS:000350239400015 ER PT J AU Housman, KJ Swift, AT Oyler, JM AF Housman, Kathleen J. Swift, Austin T. Oyler, Jonathan M. TI Fragmentation Pathways and Structural Characterization of 14 Nerve Agent Compounds by Electrospray Ionization Tandem Mass Spectrometry SO JOURNAL OF ANALYTICAL TOXICOLOGY LA English DT Article ID CHEMICAL WARFARE AGENTS; LIQUID-CHROMATOGRAPHY; ION-TRAP; HYDROLYSIS PRODUCTS; VX; VERIFICATION; SOIL; SARIN; PHASE; SOMAN AB Organophosphate nerve agents (OPNAs) are some of the most widely used and proliferated chemical warfare agents. As evidenced by recent events in Syria, these compounds remain a serious military and terrorist threat to human health because of their toxicity and the ease with which they can be used, produced and stored. There are over 2,000 known, scheduled compounds derived from common parent structures with many more possible. To address medical, forensic, attribution, remediation and other requirements, laboratory systems have been established to provide the capability to analyze 'unknown' samples for the presence of these compounds. Liquid chromatography/mass spectrometric methods have been validated and are routinely used in the analysis of samples for a very limited number of these compounds, but limited data exist characterizing the electrospray ionization (ESI) and mass spectrometric fragmentation pathways of the compound families. This report describes results from direct infusion ESI/MS, ESI/MS2 and ESI/MS3 analysis of 14 G and V agents, the major OPNA families, using an AB Sciex 4000 QTrap. Using a range of conditions, spectra were acquired and characteristic fragments identified. The results demonstrated that the reproducible and predictable fragmentation of these compounds by ESI/MS, ESI/MS2 and ESI/MS3 can be used to describe systematic fragmentation pathways specific to compound structural class. These fragmentation pathways, in turn, may be useful as a predictive tool in the analysis of samples by screening and confirmatory laboratories to identify related compounds for which authentic standards are not readily available. C1 [Housman, Kathleen J.; Swift, Austin T.; Oyler, Jonathan M.] US Army, Med Res Inst Chem Def, Aberdeen Proving Ground, MD 21010 USA. RP Oyler, JM (reprint author), US Army, Med Res Inst Chem Def, 3100 Ricketts Point Rd, Aberdeen Proving Ground, MD 21010 USA. EM jonathan.m.oyler.civ@mail.mil FU Defense Threat Reduction Agency-Joint Science and Technology Office, Medical ST Division FX The views expressed in this article are those of the author(s) and do not reflect the official policy of the Department of Army, Department of Defense or the U.S. Government. This research was supported by the Defense Threat Reduction Agency-Joint Science and Technology Office, Medical S&T Division. NR 23 TC 3 Z9 3 U1 3 U2 44 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0146-4760 EI 1945-2403 J9 J ANAL TOXICOL JI J. Anal. Toxicol. PD MAR PY 2015 VL 39 IS 2 BP 96 EP 105 DI 10.1093/jat/bku135 PG 10 WC Chemistry, Analytical; Toxicology SC Chemistry; Toxicology GA CC3BL UT WOS:000350219100003 PM 25519457 ER PT J AU Chan, RK Aden, J Wu, J Hale, RG Renz, EM Wolf, SE AF Chan, Rodney K. Aden, James Wu, Jesse Hale, Robert G. Renz, Evan M. Wolf, Steven E. TI Operative Utilization Following Severe Combat-Related Burns SO JOURNAL OF BURN CARE & RESEARCH LA English DT Article ID SKIN; SURGEONS; WAR AB The goal of burn surgical therapy is to minimize mortality and to return survivors to their preinjury state. Prompt removal of the burn eschar, early durable coverage, and late corrections of functional deformities are the basic surgical principles. The operative burden, while presumed to be substantial and significant, is neither well described nor quantified. The burn registry at the U.S. Institute of Surgical Research Burn Center was queried from March 2003 to August 2011 for all active duty burn admissions; active duty subjects were chosen to eliminate subject follow-up as a significant variable. Subject demographics including age, sex, branch of service, injury type, injury severity score, transfusion, allograft use, length of stay, mechanism of injury, and survival were tabulated as were their percentage TBSA, specific body region involvement, and nature and dates of operations performed. Univariate analysis and multiple logistic regressions were performed to determine independent factors which predict early and late operative burden. In the 8-year study period, 864 active duty patients were admitted to the burn center. Among them, 569 (66%) were operative in nature. The operations that were performed during acute hospitalization were 62%, while the remaining 38% were performed following discharge. A linear relationship exists between TBSA and the number of acute operations with an average of one acute operation required per 5% TBSA. No direct relationships however were found between TBSA and the number of reconstructive operations. Based on multiple logistic regression, battle vs nonbattle (odds ratio [OR], 0.559; 95% confidence interval [CI], 0.298-1.050; P = .0706), injury severity score (OR, 1.021; 95% CI, 1.003-1.039; P = .0222), intensive care unit length of stay (OR, 1.076; 95% CI, 1.053-1.099; P .0001), allograft use (OR, 2.610; 95% CI, 1.472-4.628; P = .0010), and TBSA of the trunk (OR, 0.982; 95% CI, 0.965-1.000; P = .0439) (but not overall TBSA) were associated with a high acute operative burden. Battle vs nonbattle (OR, 0.546; 95% CI, 0.360-0.829; P = .0045), and TBSA of the upper extremities (OR, 1.008; 95% CI, 1.002-1.013; P = .0042) were noted to be significant variables in predicting late reconstruction operations. The operative burden of burn, not previously well characterized, consists of operations performed during as well as after the initial hospitalization. While injury severity and truncal involvement are significant determinants of acute surgical therapy, the presence of upper extremity burns is a significant determinant of reconstruction following discharge. C1 [Chan, Rodney K.; Aden, James; Renz, Evan M.] US Army Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Chan, Rodney K.; Wu, Jesse; Hale, Robert G.] US Army Inst Surg Res, Dent & Trauma Res Detachment, Ft Sam Houston, TX USA. [Wolf, Steven E.] Univ Texas SW Med Ctr Dallas, Burn Ctr, Dallas, TX 75390 USA. RP Chan, RK (reprint author), US Army Inst Surg Res, Ft Sam Houston, TX 78234 USA. NR 20 TC 1 Z9 1 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1559-047X EI 1559-0488 J9 J BURN CARE RES JI J. Burn Care Res. PD MAR-APR PY 2015 VL 36 IS 2 BP 287 EP 296 DI 10.1097/BCR.0000000000000132 PG 10 WC Emergency Medicine; Dermatology; Surgery SC Emergency Medicine; Dermatology; Surgery GA CC5JO UT WOS:000350395100024 PM 25102231 ER PT J AU Hutchenson, KD Conner, RB Johnson, LB Bennett, HH Simms, JE Yule, DE AF Hutchenson, Kevin D. Conner, Ray B. Johnson, Lars B. Bennett, Hollis H., Jr. Simms, Janet E. Yule, Don E. TI Evaluation and Current Results of the Seismic Acoustic Impact Monitoring Assessment (SAIMA) System SO JOURNAL OF ENVIRONMENTAL AND ENGINEERING GEOPHYSICS LA English DT Article AB For the past several years, Quantum Technology Sciences (QTSI) and U.S. Army Engineering Research and Development Center (ERDC) have been developing a system to actively sustain present and future artillery ranges at zero unexploded ordnance (UXO) gains. With the Department of Defense (DoD) using over two million high-explosive (HE) munitions per year with a significant fraction as UXO, reducing costly range remediation and environmental restoration efforts will offer significant savings. The developed Seismic Acoustic Impact Monitoring Assessment (SAIMA) system is not designed for past ranges, but as a complementary technology to detect, locate within two meters, and classify UXO in near realtime to aid existing cleanup technologies. Feasibility and descriptions of system components have been previously provided (VanDeMark et al., 2009, 2010, 2013). The current system is composed of multiple buried seismic arrays encircling a mortar or artillery impact area, communications from the arrays to a central processing station, and a processing unit that employs an algorithm suite based in the seismology and statistical analysis disciplines to detect, locate, and classify the HE or UXO impact. Recent deployments of the SAIMA system have demonstrated hardware maturity and algorithm refinements to nearly enable the goal of locations within two meters. A field deployment at Ft. Sill, Oklahoma, in June 2012 demonstrated acoustic locations at a large range (QTSI, 2012). Subsequent systems tests with five arrays using a synthetic UXO source (kinetic source only; no acoustic phases) on a small field (80 m by 80 m) resolved locations within 0.5 m of ground truth with coverage ellipses at 0.1 m(2) (time and azimuth). On a small mortar field, approximately 365 m by 480 m, simulated UXO (inert rounds) were located within an average mislocation distance of 4.1 m and confidence ellipses on the order of 5.8 m by 3.8 m. Scheduled field testing in the near future will validate the system. C1 [Hutchenson, Kevin D.; Conner, Ray B.; Johnson, Lars B.] Quantum Technol Sci, Cocoa Beach, FL 32931 USA. [Bennett, Hollis H., Jr.; Simms, Janet E.; Yule, Don E.] US Army, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Hutchenson, KD (reprint author), Quantum Technol Sci, 1980 N Atlantic Ave,Suite 201, Cocoa Beach, FL 32931 USA. NR 12 TC 0 Z9 0 U1 1 U2 4 PU ENVIRONMENTAL ENGINEERING GEOPHYSICAL SOC PI DENVER PA 1720 SOUTH BELLAIRE, STE 110, DENVER, CO 80222-433 USA SN 1083-1363 J9 J ENVIRON ENG GEOPH JI J. Environ. Eng. Geophys. PD MAR PY 2015 VL 20 IS 1 BP 89 EP 100 DI 10.2113/JEEG20.1.89 PG 12 WC Geochemistry & Geophysics; Engineering, Geological SC Geochemistry & Geophysics; Engineering GA CC8IQ UT WOS:000350612100008 ER PT J AU Takala-Harrison, S Jacob, CG Arze, C Cummings, MP Silva, JC Dondorp, AM Fukuda, MM Hien, TT Mayxay, M Noedl, H Nosten, F Kyaw, MP Nhien, NTT Imwong, M Bethell, D Se, Y Lon, C Tyner, SD Saunders, DL Ariey, F Mercereau-Puijalon, O Menard, D Newton, PN Khanthavong, M Hongvanthong, B Starzengruber, P Fuehrer, HP Swoboda, P Khan, WA Phyo, AP Nyunt, MM Nyunt, MH Brown, TS Adams, M Pepin, CS Bailey, J Tan, JC Ferdig, MT Clark, TG Miotto, O MacInnis, B Kwiatkowski, DP White, NJ Ringwald, P Plowe, CV AF Takala-Harrison, Shannon Jacob, Christopher G. Arze, Cesar Cummings, Michael P. Silva, Joana C. Dondorp, Arjen M. Fukuda, Mark M. Tran Tinh Hien Mayxay, Mayfong Noedl, Harald Nosten, Francois Kyaw, Myat P. Nguyen Thanh Thuy Nhien Imwong, Mallika Bethell, Delia Se, Youry Lon, Chanthap Tyner, Stuart D. Saunders, David L. Ariey, Frederic Mercereau-Puijalon, Odile Menard, Didier Newton, Paul N. Khanthavong, Maniphone Hongvanthong, Bouasy Starzengruber, Peter Fuehrer, Hans-Peter Swoboda, Paul Khan, Wasif A. Phyo, Aung Pyae Nyunt, Myaing M. Nyunt, Myat H. Brown, Tyler S. Adams, Matthew Pepin, Christopher S. Bailey, Jason Tan, John C. Ferdig, Michael T. Clark, Taane G. Miotto, Olivo MacInnis, Bronwyn Kwiatkowski, Dominic P. White, Nicholas J. Ringwald, Pascal Plowe, Christopher V. TI Independent Emergence of Artemisinin Resistance Mutations Among Plasmodium falciparum in Southeast Asia SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article DE malaria; artemisinin resistance; Southeast Asia; Plasmodium falciparum; kelch ID PARASITE CLEARANCE; WESTERN CAMBODIA; MALARIA; ASSOCIATION; PROVINCE; PYRIMETHAMINE; NETWORKS; SPREAD AB Background. The emergence of artemisinin-resistant Plasmodium falciparum in Southeast Asia threatens malaria treatment efficacy. Mutations in a kelch protein encoded on P. falciparum chromosome 13 (K13) have been associated with resistance in vitro and in field samples from Cambodia. Methods. P. falciparum infections from artesunate efficacy trials in Bangladesh, Cambodia, Laos, Myanmar, and Vietnam were genotyped at 33 716 genome-wide single-nucleotide polymorphisms (SNPs). Linear mixed models were used to test associations between parasite genotypes and parasite clearance half-lives following artesunate treatment. K13 mutations were tested for association with artemisinin resistance, and extended haplotypes on chromosome 13 were examined to determine whether mutations arose focally and spread or whether they emerged independently. Results. The presence of nonreference K13 alleles was associated with prolonged parasite clearance half-life (P = 1.97 x 10(-12)). Parasites with a mutation in any of the K13 kelch domains displayed longer parasite clearance half-lives than parasites with wild-type alleles. Haplotype analysis revealed both population-specific emergence of mutations and independent emergence of the same mutation in different geographic areas. Conclusions. K13 appears to be a major determinant of artemisinin resistance throughout Southeast Asia. While we found some evidence of spreading resistance, there was no evidence of resistance moving westward from Cambodia into Myanmar. C1 [Takala-Harrison, Shannon; Jacob, Christopher G.; Nyunt, Myaing M.; Brown, Tyler S.; Adams, Matthew; Pepin, Christopher S.; Bailey, Jason; Plowe, Christopher V.] Univ Maryland, Sch Med, Ctr Vaccine Dev, Howard Hughes Med Inst, Baltimore, MD 21201 USA. [Arze, Cesar; Silva, Joana C.] Univ Maryland, Sch Med, Inst Genome Sci, Baltimore, MD 21201 USA. [Cummings, Michael P.] Univ Maryland, Ctr Bioinformat & Computat Biol, College Pk, MD 20742 USA. [Tan, John C.] Roche NimbleGen, Res & Dev, Madison, WI USA. [Ferdig, Michael T.] Univ Notre Dame, Dept Biol Sci, Eck Inst Global Hlth, Indiana, PA USA. [Dondorp, Arjen M.; Nosten, Francois; Phyo, Aung Pyae; Miotto, Olivo; White, Nicholas J.] Mahidol Univ, Fac Trop Med, Mahidol Oxford Trop Med Res Unit, Bangkok, Thailand. [Imwong, Mallika] Mahidol Univ, Fac Trop Med, Dept Mol Trop Med & Genet, Bangkok, Thailand. [Fukuda, Mark M.; Bethell, Delia; Tyner, Stuart D.; Saunders, David L.] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Phyo, Aung Pyae] Mahidol Univ, Fac Trop Med, Shoklo Malaria Res Unit, Mae Sot, Thailand. [Phyo, Aung Pyae] Mahidol Univ, Fac Trop Med, Mahidol Oxford Trop Med Res Unit, Mae Sot, Thailand. [Tran Tinh Hien; Nguyen Thanh Thuy Nhien] Oxford Univ Clin Res Unit, Ctr Trop Med, Ho Chi Minh City, Vietnam. [Mayxay, Mayfong; Newton, Paul N.] Mahosot Hosp, Microbiol Lab, Lao Oxford Mahosot Hosp Wellcome Trust Res Unit, Viangchan, Laos. [Mayxay, Mayfong] Univ Hlth Sci, Fac Postgrad Studies, Viangchan, Laos. [Mayxay, Mayfong] Univ Hlth Sci, Fac Postgrad Studies, Viangchan, Laos. [Khanthavong, Maniphone; Hongvanthong, Bouasy] Ctr Malariol Parasitol & Entomol, Viangchan, Laos. [Nosten, Francois; Newton, Paul N.] Univ Oxford, Nuffield Dept Med, Ctr Trop Med, Hinxton, Cambs, England. [Miotto, Olivo; Kwiatkowski, Dominic P.] Univ Oxford, MRC Ctr Genom & Global Hlth, Hinxton, Cambs, England. [Miotto, Olivo; Kwiatkowski, Dominic P.] Wellcome Trust Sanger Inst, Hinxton, Cambs, England. [Clark, Taane G.] London Sch Hyg & Trop Med, Fac Epidemiol & Populat Hlth, Hinxton, Cambs, England. [Clark, Taane G.] London Sch Hyg & Trop Med, Fac Infect & Trop Dis, Hinxton, Cambs, England. [Miotto, Olivo; MacInnis, Bronwyn; Kwiatkowski, Dominic P.] Wellcome Trust Sanger Inst, Malaria Programme, Hinxton, Cambs, England. [Noedl, Harald; Starzengruber, Peter; Fuehrer, Hans-Peter; Swoboda, Paul] Med Univ Vienna, Inst Specif Prophylaxis & Trop Med, Vienna, Austria. [Kyaw, Myat P.; Nyunt, Myat H.] Dept Med Res Lower Myanmar, Yangon, Myanmar. [Se, Youry; Lon, Chanthap] Armed Forces Res Inst Med Sci, Phnom Penh, Cambodia. [Menard, Didier] Inst Pasteur Cambodge, Malaria Mol Epidemiol Unit, Phnom Penh, Cambodia. [Ariey, Frederic] Inst Pasteur, Parasitol & Mycol Dept, GGIV Unit, Paris, France. [Mercereau-Puijalon, Odile] Inst Pasteur, Parasite Mol Immunol Unit, Paris, France. [Khan, Wasif A.] Int Ctr Diarrhoeal Dis Res, Dhaka 1000, Bangladesh. [Ringwald, Pascal] WHO, Global Malaria Programme, Drug Resistance & Containment Unit, CH-1211 Geneva, Switzerland. RP Takala-Harrison, S (reprint author), Univ Maryland, Sch Med, Ctr Vaccine Dev, 685 W Baltimore St,HSF1-480, Baltimore, MD 21201 USA. EM stakala@medicine.umaryland.edu RI Ferdig, Michael/C-6627-2016; OI Miotto, Olivo/0000-0001-8060-6771; Kwiatkowski, Dominic/0000-0002-5023-0176; Pyae Phyo, Aung/0000-0002-0383-9624 FU National Institute of Allergy and Infectious Diseases at the National Institutes of Health [R01AI101713, U19AI10820]; World Health Organization Global Malaria Programme; Doris Duke Charitable Foundation; Howard Hughes Medical Institute; Wellcome Trust through Wellcome Trust Sanger Institute [098051]; Wellcome Trust Centre for Human Genetics [090532/Z/09/Z]; Resource Centre for Genomic Epidemiology of Malaria [090770/Z/09/Z]; Wellcome Trust Mahidol University Oxford Tropical Medicine Research Programme through Wellcome Trust; Centre for Genomics and Global Health, through the Medical Research Council [G0600718] FX This work was supported by the National Institute of Allergy and Infectious Diseases at the National Institutes of Health (grant R01AI101713 to S.T.-H. and grant U19AI10820.), the World Health Organization Global Malaria Programme, the Doris Duke Charitable Foundation, and the Howard Hughes Medical Institute, for genomic analyses; the Wellcome Trust, through core funding of the Wellcome Trust Sanger Institute (grant 098051), for sequencing analyses; the Wellcome Trust Centre for Human Genetics (grant 090532/Z/09/Z), the Resource Centre for Genomic Epidemiology of Malaria (grant 090770/Z/09/Z), and the Wellcome Trust Mahidol University Oxford Tropical Medicine Research Programme, through core funding from the Wellcome Trust; and the Centre for Genomics and Global Health, through the Medical Research Council (grant G0600718). NR 29 TC 99 Z9 102 U1 7 U2 39 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0022-1899 EI 1537-6613 J9 J INFECT DIS JI J. Infect. Dis. PD MAR 1 PY 2015 VL 211 IS 5 BP 670 EP 679 DI 10.1093/infdis/jiu491 PG 10 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA CC3CL UT WOS:000350222000002 PM 25180241 ER PT J AU Hruby, A Hill, OT Bulathsinhala, L McKinnon, CJ Montain, SJ Young, AJ Smith, TJ AF Hruby, Adela Hill, Owen T. Bulathsinhala, Lakmini McKinnon, Craig J. Montain, Scott J. Young, Andrew J. Smith, Tracey J. TI Trends in Overweight and Obesity in Soldiers Entering the US Army, 1989-2012 SO OBESITY LA English DT Article ID WEIGHT CONTROL PROGRAM; RECRUIT MOTIVATION; MILITARY PERSONNEL; UNITED-STATES; PREDICTORS; ENLISTMENT; ATTRITION; EPIDEMIC; STRENGTH AB ObjectiveThe US Army recruits new soldiers from an increasingly obese civilian population. The change in weight status at entry into the Army between 1989 and 2012 and the demographic characteristics associated with overweight/obesity at entry were examined. Methods1,741,070 unique individuals with complete sex, age, and anthropometric information contributed data to linear and logistic regressions examining time trends and associations between demographic characteristics and overweight/obesity. ResultsThe prevalence of overweight (body mass index 25-<30 kg/m(2)) generally increased, from 25.8% (1989) to 37.2% (2012), peaking at 37.9% (2011). The prevalence of obesity (body mass index 30 kg/m(2)) also increased from 5.6% (1989) to 8.0% (2012), peaking at 12.3% (2009); 2005-2009 annual prevalence exceeded 10%. The most consistent demographic characteristics predicting overweight/obesity were male sex, older age, Hispanic or Asian/Pacific Island race/ethnicity, and being married. There were no distinct geographic trends. ConclusionsThe US Army is not immune to the US obesity epidemic. Demographic characteristics associated with being overweight or obese should be considered when developing military-sponsored weight management programs for new soldiers. C1 [Hruby, Adela; Montain, Scott J.; Young, Andrew J.; Smith, Tracey J.] US Army Res Inst Environm Med, Mil Nutr Div, Natick, MA 01760 USA. [Hruby, Adela] Harvard Univ, Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA. [Hill, Owen T.; Bulathsinhala, Lakmini; McKinnon, Craig J.] US Army Res Inst Environm Med, Mil Performance Div, Natick, MA USA. [Hill, Owen T.] Ft Sam, Ctr Intrepid, Houston, TX USA. RP Smith, TJ (reprint author), US Army Res Inst Environm Med, Mil Nutr Div, Natick, MA 01760 USA. EM tracey.smith10.civ@mail.mil FU Postgraduate Research Participation Program at the US Army Medical Research Institute of Environmental Medicine FX Dr. Hruby's contribution to this research was supported by an appointment to the Postgraduate Research Participation Program at the US Army Medical Research Institute of Environmental Medicine administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the US Department of Energy and USAMRMC. NR 29 TC 4 Z9 4 U1 0 U2 5 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1930-7381 EI 1930-739X J9 OBESITY JI Obesity PD MAR PY 2015 VL 23 IS 3 BP 662 EP 670 DI 10.1002/oby.20978 PG 9 WC Endocrinology & Metabolism; Nutrition & Dietetics SC Endocrinology & Metabolism; Nutrition & Dietetics GA CC3LG UT WOS:000350249700023 PM 25611465 ER PT J AU Stevens, JR Pfannenstiel, TJ AF Stevens, Jayne R. Pfannenstiel, Travis J. TI The Otologist's Tuning Fork Examination-Are You Striking It Correctly? SO OTOLARYNGOLOGY-HEAD AND NECK SURGERY LA English DT Article DE tuning fork; fundamental frequency; scanning vibrometer AB Objective To determine if the manner in which a tuning fork is activated affects its vibrational response. Study Design Diagnostic test assessment. Setting Hearing Center of Excellence laboratory. Subjects and Methods A Polytec OFV-5000 scanning vibrometer was used to measure the vibrational response of 256-Hz, 512-Hz, and 1024-Hz tuning forks after activation. The tuning forks were activated to varying intensities by striking 4 unique surfaces: the head, palm, a metal surface, and a wood table. Results The fundamental frequency of the individual tuning fork was the dominant observed frequency in all testing scenarios. Additional nonharmonic frequencies were noted when the 256-Hz and 512-Hz tuning forks were struck off metal and wooden surfaces. Conclusions Additional nonfundamental sound frequencies produced secondary to striking a tuning fork off a metal object or a wooden table could affect clinical tuning fork examination and complicate decisions regarding surgical candidacy. C1 [Stevens, Jayne R.; Pfannenstiel, Travis J.] Brooke Army Med Ctr, Dept Otolaryngol Head & Neck Surg, San Antonio, TX USA. RP Stevens, JR (reprint author), Brooke Army Med Ctr, Dept Otolaryngol Head & Neck Surg, MCHE SDT Otolaryngol, 3551 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM jayne.r.stevens@gmail.com NR 4 TC 0 Z9 0 U1 0 U2 1 PU SAGE PUBLICATIONS LTD PI LONDON PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND SN 0194-5998 EI 1097-6817 J9 OTOLARYNG HEAD NECK JI Otolaryngol. Head Neck Surg. PD MAR PY 2015 VL 152 IS 3 BP 477 EP 479 DI 10.1177/0194599814559697 PG 3 WC Otorhinolaryngology; Surgery SC Otorhinolaryngology; Surgery GA CC6LS UT WOS:000350477100015 PM 25475500 ER PT J AU Sanders, ME Peterson, JA AF Sanders, Mary E. Peterson, James A. TI More Than a Name on the Wall Reflections on a Life Well Lived SO ACSMS HEALTH & FITNESS JOURNAL LA English DT Editorial Material C1 [Sanders, Mary E.] Univ Nevada, Sch Med, Div Wellness & Weight Management, Reno, NV 89557 USA. [Sanders, Mary E.] Univ Nevada, Sch Publ Hlth, Reno, NV 89557 USA. [Peterson, James A.] US Mil Acad, Phys Educ, West Point, NY USA. RP Sanders, ME (reprint author), Univ Nevada, Sch Med, Div Wellness & Weight Management, Reno, NV 89557 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1091-5397 EI 1536-593X J9 ACSMS HEALTH FIT J JI ACSMS Health Fit. J. PD MAR-APR PY 2015 VL 19 IS 2 BP 27 EP 29 PG 3 WC Sport Sciences SC Sport Sciences GA CC2BN UT WOS:000350149700007 ER PT J AU Tran, DD Littlefield, PD AF Tran, Daniel D. Littlefield, Philip D. TI Late presentation of subcutaneous emphysema and pneumomediastinum following elective tonsillectomy SO AMERICAN JOURNAL OF OTOLARYNGOLOGY LA English DT Article ID ADENOTONSILLECTOMY; COMPLICATION AB Subcutaneous emphysema and pneumomediastinum are rare complications following elective tonsillectomy. Although the mechanism of injury is unclear, air is thought to enter through either the buccopharyngeal mucosa during surgery or via alveolar rupture during positive pressure ventilation. Patients typically present immediately after surgery or upon anesthesia emergence. We describe a case of delayed pneumomediastinum in a 30 year-old female who presented 4 days after surgery. With only one other case described, we review the literature and remind the reader to be cognizant of this late complication. Published by Elsevier Inc. C1 [Tran, Daniel D.] Tripler Army Med Ctr, US Army, Dept Otolaryngol, Honolulu, HI USA. [Littlefield, Philip D.] Tripler Army Med Ctr, US Army, Honolulu, HI USA. RP Tran, DD (reprint author), Tripler Army Med Ctr, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM daniel.d.tran.mil@mail.mil NR 15 TC 2 Z9 2 U1 0 U2 0 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0196-0709 EI 1532-818X J9 AM J OTOLARYNG JI Am. J. Otolaryngol. PD MAR-APR PY 2015 VL 36 IS 2 BP 299 EP 302 DI 10.1016/j.amjoto.2014.10.034 PG 4 WC Otorhinolaryngology SC Otorhinolaryngology GA CB9FJ UT WOS:000349937100037 PM 25480365 ER PT J AU Tati, S Ko, BJ Cao, G Swami, A La Porta, TF AF Tati, Srikar Ko, Bong Jun Cao, Guohong Swami, Ananthram La Porta, Thomas F. TI Adaptive Algorithms for Diagnosing Large-Scale Failures in Computer Networks SO IEEE TRANSACTIONS ON PARALLEL AND DISTRIBUTED SYSTEMS LA English DT Article DE Fault diagnosis; large-scale failures; incomplete information; clustered failures ID LOCALIZATION AB We propose a greedy algorithm, Cluster-MAX-COVERAGE (CMC), to efficiently diagnose large-scale clustered failures. We primarily address the challenge of determining faults with incomplete symptoms. CMC makes novel use of both positive and negative symptoms to output a hypothesis list with a low number of false negatives and false positives quickly. CMC requires reports from about half as many nodes as other existing algorithms to determine failures with 100 percent accuracy. Moreover, CMC accomplishes this gain significantly faster (sometimes by two orders of magnitude) than an algorithm that matches its accuracy. When there are fewer positive and negative symptoms at a reporting node, CMC performs much better than existing algorithms. We also propose an adaptive algorithm called Adaptive-MAX-COVERAGE (AMC) that performs efficiently during both independent and clustered failures. During a series of failures that include both independent and clustered, AMC results in a reduced number of false negatives and false positives. C1 [Tati, Srikar; Cao, Guohong; La Porta, Thomas F.] Penn State Univ, Inst Networking & Secur Res, University Pk, PA 16802 USA. [Ko, Bong Jun] IBM Corp, TJ Watson Res Ctr, Hawthorne, NY 10532 USA. [Swami, Ananthram] Army Res Lab, Adelphi, MD USA. RP Tati, S (reprint author), Penn State Univ, Inst Networking & Secur Res, University Pk, PA 16802 USA. EM tati@cse.psu.edu; bongjun_ko@us.ibm.com; gcao@cse.psu.edu; ananthram.swami.civ@mail.mil; tlp@cse.psu.edu FU US Army Research Laboratory; United Kingdom Ministry of Defence; Defense Threat Reduction Agency [HDTRA1-10-1-0085]; [W911NF-06-3-0001] FX The authors acknowledge the inputs of Daniel Kifer. This research was sponsored by the US Army Research Laboratory and the United Kingdom Ministry of Defence, and was accomplished under Agreement Number W911NF-06-3-0001. The views and conclusions contained in this document are those of the author(s) and should not be interpreted as representing the official policies, either expressed or implied, of the US Army Research Laboratory, the US Government, the United Kingdom Ministry of Defence or the United Kingdom Government. The US and the United Kingdom Governments are authorized to reproduce and distribute reprints for Government purposes notwithstanding any copyright notation hereon. This work was supported in part by the Defense Threat Reduction Agency under Grant HDTRA1-10-1-0085. NR 16 TC 1 Z9 1 U1 1 U2 4 PU IEEE COMPUTER SOC PI LOS ALAMITOS PA 10662 LOS VAQUEROS CIRCLE, PO BOX 3014, LOS ALAMITOS, CA 90720-1314 USA SN 1045-9219 EI 1558-2183 J9 IEEE T PARALL DISTR JI IEEE Trans. Parallel Distrib. Syst. PD MAR PY 2015 VL 26 IS 3 BP 646 EP 656 DI 10.1109/TPDS.2014.2311814 PG 11 WC Computer Science, Theory & Methods; Engineering, Electrical & Electronic SC Computer Science; Engineering GA CB6XG UT WOS:000349769500003 ER PT J AU Chow, YL Pavone, M Sadler, BM Carpin, S AF Chow, Yin-Lam Pavone, Marco Sadler, Brian M. Carpin, Stefano TI Trading Safety Versus Performance: Rapid Deployment of Robotic Swarms With Robust Performance Constraints SO JOURNAL OF DYNAMIC SYSTEMS MEASUREMENT AND CONTROL-TRANSACTIONS OF THE ASME LA English DT Article ID COVERAGE AB In this paper, we consider a stochastic deployment problem, where a robotic swarm is tasked with the objective of positioning at least one robot at each of a set of pre-assigned targets while meeting a temporal deadline. Travel times and failure rates are stochastic but related, inasmuch as failure rates increase with speed. To maximize chances of success while meeting the deadline, a control strategy has therefore to balance safety and performance. Our approach is to cast the problem within the theory of constrained Markov decision processes (CMDPs), whereby we seek to compute policies that maximize the probability of successful deployment while ensuring that the expected duration of the task is bounded by a given deadline. To account for uncertainties in the problem parameters, we consider a robust formulation and we propose efficient solution algorithms, which are of independent interest. Numerical experiments confirming our theoretical results are presented and discussed. C1 [Chow, Yin-Lam] Stanford Univ, Inst Computat & Math Engn, Stanford, CA 94305 USA. [Pavone, Marco] Stanford Univ, Dept Aeronaut & Astronaut, Stanford, CA 94305 USA. [Sadler, Brian M.] Army Res Lab, Adelphi, MD 20783 USA. [Carpin, Stefano] Univ Calif, Sch Engn, Merced, CA 95343 USA. RP Chow, YL (reprint author), Stanford Univ, Inst Computat & Math Engn, Stanford, CA 94305 USA. EM ychow@stanford.edu; pavone@stanford.edu; brian.m.sadler6.civ@mail.mil; scarpin@ucmerced.edu FU ARL [MAST-SUPP-13-6-CNC] FX Stefano Carpin is partially supported by ARL under Contract MAST-SUPP-13-6-CNC. Any opinions, findings, and conclusions or recommendations expressed in these materials are those of the authors and should not be interpreted as representing the official policies, either expressly or implied, of the funding agencies of the U.S. Government. NR 30 TC 2 Z9 2 U1 1 U2 9 PU ASME PI NEW YORK PA TWO PARK AVE, NEW YORK, NY 10016-5990 USA SN 0022-0434 EI 1528-9028 J9 J DYN SYST-T ASME JI J. Dyn. Syst. Meas. Control-Trans. ASME PD MAR PY 2015 VL 137 IS 3 SI SI AR 031005 DI 10.1115/1.4028117 PG 11 WC Automation & Control Systems; Instruments & Instrumentation SC Automation & Control Systems; Instruments & Instrumentation GA CB6RO UT WOS:000349754500007 ER PT J AU Kaldy, JE Shafer, DJ Magoun, AD AF Kaldy, James E. Shafer, Deborah J. Magoun, A. Dale TI Duration of temperature exposure controls growth of Zostera japonica: Implications for zonation and colonization SO JOURNAL OF EXPERIMENTAL MARINE BIOLOGY AND ECOLOGY LA English DT Article DE Introduced seagrass; Pulsed temperature; Zonation control; Zostera japonica ID MARINA L.; VERTICAL-DISTRIBUTION; HALODULE-WRIGHTII; TEMPORAL PATTERNS; PACIFIC-NORTHWEST; SEAGRASS; BAY; WASHINGTON; SEEDLINGS; DYNAMICS AB At least two seagrass congeners in the genus Zostera are found along the Pacific Coast of North America: native Zostera marina L and the non-native Zostera japonica Aschers. & Graebn. Efforts to understand the drivers behind the expanding colonization of Z. japonica have led to interest in the biology and ecology of this species. In most locations where they co-occur, these species exhibit a disjunct vertical zonation. We experimentally consider the influence of pulsed temperature effects on Z. japonica growth as a driver of vertical zonation. In mesocosm tanks seagrass planting units were cycled from ambient to treatment temperatures (8, 20, 32 degrees C) of variable duration (2, 6, 12, 24 h) each day for 10 d and then growth was assessed. Leaf elongation and growth rates exhibited strong, statistically significant relationships with increasing duration of exposure to 20 degrees C. Plants exposed to continuous 20 degrees C temperatures grew 2.5 times faster than plants exposed to 20 degrees C for 2 h. Likewise, plants exposed to continuous 8 degrees C temperatures grew 2.5 times slower than plants at 8 degrees C for 2 h. Plants exposed to 32 degrees C maintained fairly constant growth and elongation rates regardless of the duration of exposure. Field data indicate that Z. japonica and Z. marina experience different thermal regimes in the same estuary. We suggest that intertidal zonation patterns of Z. japonica in North America are predominantly driven by seagrass temperature responses; increased duration of exposure to cold water temperatures appears to limit expansion of the Z. japonica bed lower boundary to the mid-intertidal. Additionally, we recognize characteristics that may be useful to identifying systems susceptible to colonization. Published by Elsevier B.V. C1 [Kaldy, James E.] US EPA, Western Ecol Div, Newport, OR 97365 USA. [Shafer, Deborah J.] US Army Corps Engn, Engn Res & Dev Ctr, Vicksburg, MS 39180 USA. [Magoun, A. Dale] Appl Res & Anal Inc, Tallulah, LA 71284 USA. RP Kaldy, JE (reprint author), US EPA, Western Ecol Div, 2111 SE Marine Sci Dr, Newport, OR 97365 USA. EM kaldy.jim@epa.gov NR 36 TC 5 Z9 5 U1 10 U2 42 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0022-0981 EI 1879-1697 J9 J EXP MAR BIOL ECOL JI J. Exp. Mar. Biol. Ecol. PD MAR PY 2015 VL 464 BP 68 EP 74 PG 7 WC Ecology; Marine & Freshwater Biology SC Environmental Sciences & Ecology; Marine & Freshwater Biology GA CB6IK UT WOS:000349730500009 ER PT J AU Videen, G Sun, WB Kocifaj, M Kai, KJ Kawamoto, K Horvath, H Mishchenko, M AF Videen, Gorden Sun, Wenbo Kocifaj, Miroslav Kai, Kenji Kawamoto, Kazuaki Horvath, Helmuth Mishchenko, Michael TI Topical issue on optical particle characterization and remote sensing of the atmosphere: Part II SO JOURNAL OF QUANTITATIVE SPECTROSCOPY & RADIATIVE TRANSFER LA English DT Editorial Material ID 3-DIMENSIONAL DATA ASSIMILATION; SURFACE PRESSURE MEASUREMENTS; ABSORPTION RADAR SYSTEM; LIGHT-SCATTERING; VALIDATION; MORPHOLOGY; AEROSOLS; IMPACT; LIDAR; DUST C1 [Videen, Gorden] INTA, Madrid 28850, Spain. [Videen, Gorden] Univ Cantabria, Fac Ciencias, Dept Fis Aplicada, Grp Opt, E-39005 Santander, Spain. [Videen, Gorden] US Army Res Lab, Adelphi, MD 20783 USA. [Videen, Gorden] Space Sci Inst, Boulder, CO 80301 USA. [Sun, Wenbo] Sci Syst & Applicat Inc, Hampton, VA 23666 USA. [Kocifaj, Miroslav] Slovak Acad Sci, Bratislava 84503, Slovakia. [Kai, Kenji] Nagoya Univ, Chikusa Ku, Nagoya, Aichi 4648601, Japan. [Kawamoto, Kazuaki] Nagasaki Univ, Fac Environm Studies, Nagasaki 852, Japan. [Horvath, Helmuth] Univ Vienna, Dept Phys, A-1090 Vienna, Austria. [Mishchenko, Michael] NASA, Goddard Inst Space Studies, New York, NY 10025 USA. RP Videen, G (reprint author), INTA, Ctra Ajalvir Km 4, Madrid 28850, Spain. EM gorden.w.videen.civ@mail.mil RI Mishchenko, Michael/D-4426-2012 NR 31 TC 1 Z9 1 U1 5 U2 20 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0022-4073 EI 1879-1352 J9 J QUANT SPECTROSC RA JI J. Quant. Spectrosc. Radiat. Transf. PD MAR PY 2015 VL 153 SI SI BP 1 EP 3 DI 10.1016/j.jqsrt.2015.01.005 PG 3 WC Optics; Spectroscopy SC Optics; Spectroscopy GA CB8MH UT WOS:000349883200001 ER PT J AU Wang, CJ Pan, YL Hill, SC Redding, B AF Wang, Chuji Pan, Yong-Le Hill, Steven C. Redding, Brandon TI Photophoretic trapping-Raman spectroscopy for single pollens and fungal spores trapped in air SO JOURNAL OF QUANTITATIVE SPECTROSCOPY & RADIATIVE TRANSFER LA English DT Article DE Optical trapping; Raman spectroscopy; Bioaerosols; Pollen; Fungal spores; Single particle trapped in air ID FLUORESCENCE-SPECTRUM ANALYZER; AIRBORNE BIOLOGICAL PARTICLES; RELEVANT MICROORGANISMS; ATMOSPHERIC BIOAEROSOLS; ABSORBING PARTICLES; RADIATION PRESSURE; AEROSOL-PARTICLES; AQUEOUS-SOLUTION; BACTERIAL-CELLS; IDENTIFICATION AB Photophoretic trapping-Raman spectroscopy (PTRS) is a new technique for measuring Raman spectra of particles that are held in air using photophoretic forces. It was initially demonstrated with Raman spectra of strongly-absorbing carbon nanoparticles (Pan et al. [44] (Opt Express 2012)). In the present paper we report the first demonstration of the use of PTRS to measure Raman spectra of absorbing and weakly-absorbing bioaerosol particles (pollens and spores). Raman spectra of three pollens and one smut spore in a size range of 6.2-41.8 mu m illuminated at 488 nm are shown. Quality spectra were obtained in the Raman shift range of 1600-3400 cm(-1) in this exploratory study. Distinguishable Raman scattering signals with one or a few clear Raman peaks for all four aerosol particles were observed within the wavenumber region 2940-3030 cm(-1). Peaks in this region are consistent with previous reports of Raman peaks in the 1600-3400 cm(-1) range for pollens and spores excited at 514 nm measured by a conventional Raman spectrometer. Noise in the spectra, the fluorescence background, and the weak Raman signals in most of the 1600-3400 cm(-1) region make some of the spectral features barely discernable or not discernable for these bioaerosols except the strong signal within 2940-3030 cm(-1). Up to five bands are identified in the three pollens and only two bands appear in the fungal spore, but this may be because the fungal spore is so much smaller than any of the pollens. The fungal spore signal relative to the air-nitrogen Raman band is approximately 10 times smaller than that ratio for the pollens. The five bands are tentatively assigned to the CH2 symmetric stretch at 2948 cm(-1), CH2 Fermi resonance stretch at 2970 cm(-1), CH3 symmetric stretch at 2990 cm(-1), CH3 out-of-plane end asymmetric stretch at 3010 cm(-1), and unsaturated = CH stretch at 3028 cm(-1). The two dominant bands of the up-to-five Raman bands in the 2940-3030 cm(-1) region have a consistent band spacing of 25 cm(-1) in all four aerosols. Finally we discuss improvements to the PTRS that should provide a system which can trap a higher fraction of particle types and obtain Raman spectra over a larger range (e.g., 200-3600 cm(-1)) than those achieved here. Published by Elsevier Ltd. C1 [Wang, Chuji; Pan, Yong-Le; Hill, Steven C.; Redding, Brandon] US Army Res Lab, Adelphi, MD 20783 USA. [Wang, Chuji] Mississippi State Univ, Starkville, MS 39759 USA. RP Pan, YL (reprint author), US Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM yongle.pan.civ@mail.mil FU Defense Threat Reduction Agency (DTRA) [HDTRA136477, HDTRA1310184]; US Army Research Laboratory mission funds; US Army Research Office [W911NF-13-1-0429, W911NF-13-1-0297] FX This research was supported by the Defense Threat Reduction Agency (DTRA) under Contract number HDTRA136477 and HDTRA1310184, US Army Research Laboratory mission funds, and US Army Research Office Grants W911NF-13-1-0429 and W911NF-13-1-0297. NR 63 TC 8 Z9 8 U1 2 U2 31 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0022-4073 EI 1879-1352 J9 J QUANT SPECTROSC RA JI J. Quant. Spectrosc. Radiat. Transf. PD MAR PY 2015 VL 153 SI SI BP 4 EP 12 DI 10.1016/j.jqsrt.2014.11.004 PG 9 WC Optics; Spectroscopy SC Optics; Spectroscopy GA CB8MH UT WOS:000349883200002 ER PT J AU Ratnesar-Shumate, S Pan, YL Hill, SC Kinahan, S Corson, E Eshbaugh, J Santarpia, JL AF Ratnesar-Shumate, Shanna Pan, Yong-Le Hill, Steven C. Kinahan, Sean Corson, Elizabeth Eshbaugh, Jonathan Santarpia, Joshua L. TI Fluorescence spectra and biological activity of aerosolized bacillus spores and MS2 bacteriophage exposed to ozone at different relative humidities in a rotating drum SO JOURNAL OF QUANTITATIVE SPECTROSCOPY & RADIATIVE TRANSFER LA English DT Article DE Bioaerosols; Spectroscopy; Bacillus; Bacteriophage; Ozone; Relative humidity ID REAL-TIME MEASUREMENT; OPEN-AIR; BIOAEROSOLS; EXCITATION; WAVELENGTH; PARTICLES; PROTEINS; MODEL; DNA AB Biological aerosols (bioaerosols) released into the environment may undergo physical and chemical transformations when exposed to atmospheric constituents such as solar irradiation, reactive oxygenated species, ozone, free radicals, water vapor and pollutants. Aging experiments were performed in a rotating drum chamber subjecting bioaerosols, Bacillus thuringiensis Al Hakam (BtAH) spores and MS2 bacteriophages to ozone at 0 and 150 ppb, and relative humidities (RH) at 10%, 50%, and 80+%. Fluorescence spectra and intensities of the aerosols as a function of time in the reaction chamber were measured with a single particle fluorescence spectrometer (SPFS) and an Ultra-Violet Aerodynamic Particle Sizer (R) Spectrometer (UV-APS). Losses in biological activity were measured by culture and quantitative polymerase chain reaction (q-PCR) assay. For both types of aerosols the largest change in fluorescence emission was between 280 and 400 nm when excited at 263 nm followed by fluorescence emission between 380 and 700 nm when excited at 351 nm. The fluorescence for both BtAH and MS2 were observed to decrease significantly at high ozone concentration and high RH when excited at 263 nm excitation. The decreases in 263 nm excited fluorescence are indicative of hydrolysis and oxidation of tryptophan in the aerosols. Fluorescence measured with the UV-APS (355-nm excitation) increased with time for both BtAH and MS2 aerosols. A two log loss of MS2 bacteriophage infectivity was observed in the presence of ozone at similar to 50% and 80% RH when measured by culture and normalized for physical losses by q-PCR. Viability of BtAH spores after exposure could not be measured due to the loss of genomic material during experiments, suggesting degradation of extracelluar DNA attributable to oxidation. The results of these studies indicate that the physical and biological properties of bioaerosols change significantly after exposure to ozone and water vapor. (c) 2014 The Authors. Published by Elsevier Ltd. C1 [Ratnesar-Shumate, Shanna; Kinahan, Sean; Corson, Elizabeth; Eshbaugh, Jonathan] Johns Hopkins Univ, Appl Phys Lab, Laurel, MD USA. [Ratnesar-Shumate, Shanna; Santarpia, Joshua L.] Univ Maryland Baltimore Cty, Baltimore, MD 21250 USA. [Pan, Yong-Le; Hill, Steven C.] US Army Res Lab, Adelphi, MD 20783 USA. [Santarpia, Joshua L.] Sandia Natl Labs, Albuquerque, NM 87123 USA. RP Santarpia, JL (reprint author), Sandia Natl Labs, 1515 Eubank SE, Albuquerque, NM 87123 USA. EM jsantar@sandia.gov FU Defense Threat Reduction Agency FX The authors would like to thank Dr. Sari Paikoff at the Defense Threat Reduction Agency for providing the funding for this research. NR 32 TC 4 Z9 4 U1 4 U2 23 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0022-4073 EI 1879-1352 J9 J QUANT SPECTROSC RA JI J. Quant. Spectrosc. Radiat. Transf. PD MAR PY 2015 VL 153 SI SI BP 13 EP 28 DI 10.1016/j.jqsrt.2014.10.003 PG 16 WC Optics; Spectroscopy SC Optics; Spectroscopy GA CB8MH UT WOS:000349883200003 ER PT J AU Bianchini, A Gonzalez, CR AF Bianchini, Alessandra Gonzalez, Carlos R. TI Reformulation of the Design Procedure for Aggregate-Surfaced Airfield Pavements SO JOURNAL OF TRANSPORTATION ENGINEERING LA English DT Article DE Unsurfaced pavement; Design procedure; Airfield pavement; Frohlich stress distribution AB During military contingency operations, aircraft are required to land, taxi, and takeoff on unpaved surfaces. In some cases, operational time limitations do not allow for the construction of paved surfaces to establish airfield operations. The original flexible pavement design procedure for paved surfaces, which is based on the California Bearing Ratio (CBR) and the -factor (Alpha-factor), was extended and applied to the design and evaluation of aggregate-surfaced pavements. With the reformulation of the CBR-Alpha for the design of flexible pavements, efforts were also directed at defining a new equation for the design of aggregate-surfaced airfields. This paper focuses on the development of a new CBR-Beta procedure for the design and evaluation of aggregate-surfaced airfields. Data from previous studies conducted on aggregate-surfaced full-scale test sections were used for this purpose. The new performance curve proposed in this paper for aggregate-surfaced airfields has the same format as the equation that was proposed and accepted for flexible pavements. C1 [Bianchini, Alessandra] Air Force Civil Engn Ctr AFCEC CXAE, Tyndall AFB, FL 32403 USA. [Bianchini, Alessandra; Gonzalez, Carlos R.] US Army, Engn Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Bianchini, A (reprint author), Air Force Civil Engn Ctr AFCEC CXAE, 139 Barnes Dr,Suite 2, Tyndall AFB, FL 32403 USA. EM Alessandra.Bianchini@us.af.mil; carlos.r.gonzalez@usace.army.mil NR 15 TC 0 Z9 0 U1 2 U2 9 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 0733-947X EI 1943-5436 J9 J TRANSP ENG JI J. Transp. Eng. PD MAR PY 2015 VL 141 IS 3 AR 04014086 DI 10.1061/(ASCE)TE.1943-5436.0000752 PG 12 WC Engineering, Civil; Transportation Science & Technology SC Engineering; Transportation GA CB7YT UT WOS:000349845500005 ER PT J AU Williams, SG Collen, J Orr, N Holley, AB Lettieri, CJ AF Williams, Scott G. Collen, Jacob Orr, Nicholas Holley, Aaron B. Lettieri, Christopher J. TI Sleep disorders in combat-related PTSD SO SLEEP AND BREATHING LA English DT Article DE Combat related sleep disorder; Insomnia; Obstructive sleep apnea; Sleep-disordered breathing; Post-traumatic stress disorder ID POSTTRAUMATIC-STRESS-DISORDER; SEXUAL-ASSAULT SURVIVORS; MILITARY PERSONNEL; CRIME VICTIMS; FIRE EVACUEES; SYMPTOMS; APNEA; VETERANS; INSOMNIA; DISTURBANCE AB We sought to assess the rate of sleep complaints and sleep disorders among active duty soldiers with deployment-related PTSD and to determine whether any clinical features differentiated those with sleep disorders. Retrospective review of consecutive soldiers diagnosed with PTSD. We recorded subjective measures of sleep and polysomnographic data. We compared clinical and demographic variables including psychoactive medication use, psychiatric comorbidity, and combat-related traumatic injury with the presence of sleep disorders. One hundred thirty patients were included (91.5 % male, mean age of 35.1 +/- 10.6 years, mean body mass index (BMI) 28.9 +/- 4.4 Kg/m(2)). About 88.5 % had comorbid depression, with the majority (96.2 %) taking psychoactive medications (mean 3.4 +/- 1.6 medications per patient). Over half of the cohort suffered combat-related traumatic physical injuries (54.6 %). The obstructive sleep apnea syndrome (OSAS) was diagnosed in 67.3 % (80 % of the cohort underwent polysomnography), with a mean apnea hypopnea index of 24.1 +/- 22.8 events/hour and a mean oxygen saturation nadir of 84.2 +/- 5.7 %. OSAS was significantly more common in the non-injured soldiers (72.9 vs. 38.0 %, p < 0.001). In multivariate analysis, absence of physical injury showed a trend towards predicting OSAS. Sleep complaints are common among soldiers with PTSD. We observed significantly higher rates of OSAS among those without physical injuries, raising the possibility that underlying sleep-disordered breathing is a risk factor for the development of PTSD. This potential association requires further validation. C1 [Williams, Scott G.] Womack Army Med Ctr, Ft Bragg, NC USA. [Collen, Jacob] San Antonio Mil Med Ctr, Pulm Dis Serv, Houston, TX 78234 USA. [Orr, Nicholas] Walter Reed Natl Mil Med Ctr, Dept Cardiol, Bethesda, MD USA. [Holley, Aaron B.; Lettieri, Christopher J.] Walter Reed Natl Mil Med Ctr, Bethesda, MD USA. [Williams, Scott G.; Holley, Aaron B.; Lettieri, Christopher J.] Uniformed Serv Univ Hlth Sci, Dept Med, Bethesda, MD 20814 USA. RP Collen, J (reprint author), San Antonio Mil Med Ctr, Pulm Dis Serv, 3551 Roger Brooke Dr, Houston, TX 78234 USA. EM jacob.f.collen.mil@mail.mil NR 59 TC 7 Z9 7 U1 3 U2 11 PU SPRINGER HEIDELBERG PI HEIDELBERG PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY SN 1520-9512 EI 1522-1709 J9 SLEEP BREATH JI Sleep Breath. PD MAR PY 2015 VL 19 IS 1 BP 175 EP 182 DI 10.1007/s11325-014-0984-y PG 8 WC Clinical Neurology; Respiratory System SC Neurosciences & Neurology; Respiratory System GA CB9WG UT WOS:000349983900033 PM 24752303 ER PT J AU Witkowski, S Trujillo, LT Sherman, SM Carter, P Matthews, MD Schnyer, DM AF Witkowski, Sarah Trujillo, Logan T. Sherman, Stephanie M. Carter, Patricia Matthews, Michael D. Schnyer, David M. TI An examination of the association between chronic sleep restriction and electrocortical arousal in college students SO CLINICAL NEUROPHYSIOLOGY LA English DT Article DE Chronic sleep restriction; PVT; ERP; EEG; Actigraphy; Circadian rhythms ID MILD COGNITIVE IMPAIRMENT; CIRCADIAN-RHYTHMS; SUSTAINED ATTENTION; PERFORMANCE DECREMENTS; ALZHEIMERS-DISEASE; DEPRIVATION; VIGILANCE; ACTIGRAPHY; POTENTIALS; EEG AB Objective: The deleterious neurocognitive effects of laboratory-controlled short-term sleep deprivation are well-known. The present study investigated neurocognitive changes arising from chronic sleep restriction outside the laboratory. Methods: Sleep patterns of 24 undergraduates were tracked via actigraphy across a 15-week semester. At the semester beginning, at a midpoint, and a week before finals, students performed the Psychomotor Vigilance Test (PVT) and cortical arousal was measured via event-related potentials (ERP) and resting state electroencephalography (EEG). Results: Average daily sleep decreased between Session 1 and Sessions 2 and 3. Calculated circadian rhythm measures indicated nighttime movement increased and sleep quality decreased from Sessions 1 and 2 to Session 3. Parallel to the sleep/activity measures, PVT reaction time increased between Session 1 and Sessions 2 and 3 and resting state alpha EEG reactivity magnitude and PVT-evoked P3 ERP amplitude decreased between Session 1 and Sessions 2 and 3. Cross-sectional regressions showed PVT reaction time was negatively associated with average daily sleep, alpha reactivity, and P3 changes; sleep/circadian measures were associated with alpha reactivity and/or P3 changes. Conclusions: Small, but persistent sleep deficits reduced cortical arousal and impaired vigilant attention. Significance: Chronic sleep restriction impacts neurocognition in a manner similar to laboratory controlled sleep deprivation. (C) 2014 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved. C1 [Witkowski, Sarah; Trujillo, Logan T.; Sherman, Stephanie M.; Schnyer, David M.] Univ Texas Austin, Dept Psychol, Austin, TX 78712 USA. [Carter, Patricia] Univ Texas Austin, Sch Nursing, Austin, TX 78712 USA. [Matthews, Michael D.] US Mil Acad, Dept Behav Sci & Leadership, West Point, NY USA. RP Witkowski, S (reprint author), Univ Texas Austin, Dept Psychol, 108 E Dean Keaton,Stop A8000, Austin, TX 78712 USA. EM Sadie.witkowski@utexas.edu OI Witkowski, Sarah/0000-0002-9140-3088 FU Army Grant via The Center for Strategic and Innovative Technologies at UT-Austin [W911NF-07-2-0023]; Chief of Staff of the Army FX This research was funded by Army Grant W911NF-07-2-0023 via The Center for Strategic and Innovative Technologies at UT-Austin and Chief of Staff of the Army - Grant to West Point's Network Science Center. NR 64 TC 2 Z9 2 U1 2 U2 18 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 1388-2457 EI 1872-8952 J9 CLIN NEUROPHYSIOL JI Clin. Neurophysiol. PD MAR PY 2015 VL 126 IS 3 BP 549 EP 557 DI 10.1016/j.clinph.2014.06.026 PG 9 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA CB4RX UT WOS:000349616700018 PM 25043966 ER PT J AU Pidcoke, HF Cap, AP AF Pidcoke, Heather F. Cap, Andrew P. TI Refrigerated Platelets for the Treatment of Acute Bleeding: A Review of the Literature and Reexamination of Current Standards: Reply SO SHOCK LA English DT Letter C1 [Pidcoke, Heather F.; Cap, Andrew P.] US Army, Inst Surg Res, San Antonio, TX 78234 USA. RP Pidcoke, HF (reprint author), US Army, Inst Surg Res, San Antonio, TX 78234 USA. NR 3 TC 1 Z9 1 U1 0 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1073-2322 EI 1540-0514 J9 SHOCK JI Shock PD MAR PY 2015 VL 43 IS 3 BP 298 EP + DI 10.1097/SHK.0000000000000299 PG 3 WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System & Cardiology GA CB1UE UT WOS:000349412700016 PM 26091026 ER PT J AU Beck, Z Matyas, GR Alving, CR AF Beck, Zoltan Matyas, Gary R. Alving, Carl R. TI Detection of liposomal cholesterol and monophosphoryl lipid A by QS-21 saponin and Limulus polyphemus amebocyte lysate SO BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES LA English DT Article DE Liposomal model membranes; Lipid bilayer heterogeneity; Cholesterol; QS-21 saponin; Monophosphotyl lipid A; Limulus amebocyte lysate ID PHOSPHATIDYLCHOLINE-CHOLESTEROL; PHOSPHOLIPID-VESICLES; BIOLOGICAL-MEMBRANES; UNILAMELLAR VESICLES; ADJUVANT SYSTEMS; MODEL MEMBRANES; RICH DOMAINS; EXCHANGE; BILAYERS; VACCINE AB Liposomes containing cholesterol (Chol) have long been used as an important membrane system for modeling the complex interactions of Chol with adjacent phospholipids or other lipids in a membrane environment. In this study we utilize a probe composed of QS-21, a saponin molecule that recognizes liposomal Chol and causes hemolysis of erythrocytes. The interaction of QS-21 with liposomal Chol results in a stable formulation which, after injection into the tissues of an animal, lacks toxic effects of QS-21 on neighboring cells that contain Chol, such as erythrocytes. Here we have used liposomes containing different saturated phospholipid fatty acyl groups and Chol, with or without monophosphoryl lipid A (MPLA), as model membranes. QS-21 is then employed as a probe to study the interactions of liposomal lipids on the visibility of membrane Chol. We demonstrate that changes either in the mole fraction of Chol in liposomes, or with different chain lengths of phospholipid fatty acyl groups, can have a substantial impact on the detection of Chol by the QS-21. We further show that liposomal MPLA can partially inhibit detection of the liposomal Chol by QS-21. The Limulus amebocyte lysate assay is used for binding to and detection of MPLA. Previous work has demonstrated that sequestration of MPLA into the liposomal lipid bilayer can block detection by the Limulus assay, but the binding site on the MPLA to which the Limulus protein binds is unknown. Changes in liposomal Chol concentration and phospholipid fatty acyl chain length influenced the detection of the liposome-embedded MPLA. Published by Elsevier B.V. C1 [Beck, Zoltan] Henry M Jackson Fdn Adv Mil Med, US Mil HIV Res Program, Bethesda, MD 20817 USA. [Beck, Zoltan; Matyas, Gary R.; Alving, Carl R.] Walter Reed Army Inst Res, US Mil HIV Res Program, Lab Adjuvant & Antigen Res, Silver Spring, MD 20910 USA. RP Alving, CR (reprint author), Walter Reed Army Inst Res, US Mil HIV Res Program, Lab Adjuvant & Antigen Res, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM calving@hivresearch.org OI Matyas, Gary/0000-0002-2074-2373 FU Henry M. Jackson Foundation [W81XWH-11-2-0174]; U.S. Army Medical Research and Materiel Command (MRMC) FX This work was supported through a Cooperative Agreement (W81XWH-11-2-0174) between the Henry M. Jackson Foundation for the Advancement of Military Medicine and the U.S. Army Medical Research and Materiel Command (MRMC). The authors thank Mr. Christopher Spiridon for technical assistance. The views expressed in this article are those of the authors and do not necessarily reflect the official policy of the Department of the Army, Department of Defense, or the U.S. Government NR 59 TC 7 Z9 7 U1 2 U2 17 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0005-2736 EI 0006-3002 J9 BBA-BIOMEMBRANES JI Biochim. Biophys. Acta-Biomembr. PD MAR PY 2015 VL 1848 IS 3 BP 775 EP 780 DI 10.1016/j.bbamem.2014.12.005 PG 6 WC Biochemistry & Molecular Biology; Biophysics SC Biochemistry & Molecular Biology; Biophysics GA CB4FB UT WOS:000349582500004 PM 25511587 ER PT J AU Chen, L Chen, J Lebensohn, RA Ji, YZ Heo, TW Bhattacharyya, S Chang, K Mathaudhu, S Liu, ZK Chen, LQ AF Chen, L. Chen, J. Lebensohn, R. A. Ji, Y. Z. Heo, T. W. Bhattacharyya, S. Chang, K. Mathaudhu, S. Liu, Z. K. Chen, L. -Q. TI An integrated fast Fourier transform-based phase-field and crystal plasticity approach to model recrystallization of three dimensional polycrystals SO COMPUTER METHODS IN APPLIED MECHANICS AND ENGINEERING LA English DT Article DE Phase-field method; Crystal plasticity; Grain growth; Recrystallization ID STATIC RECRYSTALLIZATION; ELASTIC INHOMOGENEITY; NONLINEAR COMPOSITES; CELLULAR-AUTOMATON; NUMERICAL-METHOD; SUBGRAIN GROWTH; SIMULATION; EVOLUTION; MICROSTRUCTURE; KINETICS AB A fast Fourier transform (FFT) based computational approach integrating phase-field method (PFM) and crystal plasticity (CP) is proposed to model recrystallization of plastically deformed polycrystals in three dimensions (3-D). CP at the grain level is employed as the constitutive description to predict the inhomogeneous distribution of strain and stress fields after plastic deformation of a polycrystalline aggregate while the kinetics of recrystallization is obtained employing a PFM in the plastically deformed grain structure. The elasto-viscoplastic equilibrium is guaranteed during each step of temporal phase-field evolution. Static recrystallization involving plasticity during grain growth is employed as an example to demonstrate the proposed computational framework. The simulated recrystallization kinetics is compared using the classical Johnson-Mehl-Avrami-Kolmogorov (JMAK) theory. This study also gives us a new computational pathway to explore the plasticity-driven evolution of 3D microstructures. Published by Elsevier B.V. C1 [Chen, L.; Ji, Y. Z.; Heo, T. W.; Bhattacharyya, S.; Chang, K.; Liu, Z. K.; Chen, L. -Q.] Penn State Univ, Dept Mat Sci & Engn, University Pk, PA 16802 USA. [Chen, J.] Penn State Univ, Altoona Coll, Dept Engn, Altoona, PA 16601 USA. [Lebensohn, R. A.] Los Alamos Natl Lab, Mat Sci & Technol Div, Los Alamos, NM 87845 USA. [Mathaudhu, S.] US Army Res Off, Div Mat Sci, Res Triangle Pk, NC 27709 USA. RP Chen, L (reprint author), Penn State Univ, Dept Mat Sci & Engn, University Pk, PA 16802 USA. EM luc28@psu.edu RI Mathaudhu, Suveen/B-4192-2009; Lebensohn, Ricardo/A-2494-2008; Liu, Zi-Kui/A-8196-2009; OI Lebensohn, Ricardo/0000-0002-3152-9105; Liu, Zi-Kui/0000-0003-3346-3696; Chen, Lei/0000-0002-3053-7373 FU Center for Computational Materials Design (CCMD); National Science Foundation (NSF) Industry/University Cooperative Research Center at Penn State [IIP-1034965]; Georgia Tech [IIP-1034968] FX This work is funded by the Center for Computational Materials Design (CCMD), a joint National Science Foundation (NSF) Industry/University Cooperative Research Center at Penn State (IIP-1034965) and Georgia Tech (IIP-1034968). NR 49 TC 12 Z9 12 U1 10 U2 47 PU ELSEVIER SCIENCE SA PI LAUSANNE PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND SN 0045-7825 EI 1879-2138 J9 COMPUT METHOD APPL M JI Comput. Meth. Appl. Mech. Eng. PD MAR 1 PY 2015 VL 285 BP 829 EP 848 DI 10.1016/j.cma.2014.12.007 PG 20 WC Engineering, Multidisciplinary; Mathematics, Interdisciplinary Applications; Mechanics SC Engineering; Mathematics; Mechanics GA CB4ZR UT WOS:000349637700036 ER PT J AU O'Bryan, TA Rini, EA Okulicz, JF Messner, O Ganesan, A Lalani, T Bavaro, MF O'Connell, RJ Agan, BK Landrum, ML AF O'Bryan, T. A. Rini, E. A. Okulicz, J. F. Messner, O. Ganesan, A. Lalani, T. Bavaro, M. F. O'Connell, R. J. Agan, B. K. Landrum, M. L. TI HIV viraemia during hepatitis B vaccination shortens the duration of protective antibody levels SO HIV MEDICINE LA English DT Article DE antibody; hepatitis B; HIV; vaccine; viraemia ID INFECTED ADULT PATIENTS; US MILITARY COHORT; IMMUNE MEMORY; T-CELL; VIRUS; PERSISTENCE; INDIVIDUALS; RESPONSES; CHILDREN; RECOMMENDATIONS AB ObjectivesIndividuals with HIV infection often have early waning of protective antibody following hepatitis B virus (HBV) vaccination. HIV viraemia at the time of vaccination may limit the durability of serum anti-HBV surface antibody (HBsAb) levels. We investigated the relationship of HIV plasma viral load (VL) and duration of HBsAb among vaccinees enrolled in the US Military HIV Natural History Study. MethodsWe included in the study participants who had no history of prior HBV infection, who had received all HBV vaccine doses after HIV diagnosis, and who had demonstrated an initial vaccine response, defined as HBsAb 10IU/L. Responders were retrospectively followed with serial HBV serology from the time of the last vaccine dose until the development of waning (HBsAb <10IU/L) or the last HBsAb measurement. Time to and risk for waning were evaluated with Kaplan-Meier survival methods and Cox proportional hazards models, respectively. ResultsA total of 186 initial vaccine responders were identified. During 570 person-years of observation, HBsAb waned in 52 of 186 participants (28%). The cumulative proportion maintaining HBsAb 10IU/L was 83% at 2 years and 56% at 5 years. Participants with an undetectable VL [hazard ratio (HR) 0.37; 95% confidence interval (CI) 0.18-0.76] or with detectable VL of 10000 copies/mL (HR 0.46; 95% CI 0.21-1.00) had reduced risk of waning. Other factors including age, number of vaccine doses, CD4 count, and receipt of highly active antiretroviral therapy (HAART) were not significantly associated with risk of waning HBsAb. ConclusionsUndetectable or low HIV VL at the time of HBV vaccination is associated with greater durability of vaccine response in patients with HIV infection. C1 [O'Bryan, T. A.; Messner, O.; Ganesan, A.; Lalani, T.; Agan, B. K.; Landrum, M. L.] Uniformed Serv Univ Hlth Sci, Infect Dis Clin Res Program, Bethesda, MD 20814 USA. [O'Bryan, T. A.; Rini, E. A.; Okulicz, J. F.; Landrum, M. L.] San Antonio Mil Med Ctr, Ft Sam Houston, TX USA. [Ganesan, A.] Walter Reed Natl Mil Med Ctr, Bethesda, MD USA. [Lalani, T.] Naval Med Ctr, Portsmouth, VA USA. [Bavaro, M. F.] Naval Med Ctr, San Diego, CA USA. [O'Connell, R. J.] Walter Reed Army Inst Res, Silver Spring, MD USA. RP O'Bryan, TA (reprint author), San Antonio Mil Med Ctr, Infect Dis Serv, 3551 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM thomas.a.obryan2.ctr@mail.mil OI Agan, Brian/0000-0002-5114-1669 FU Infectious Disease Clinical Research Program (IDCRP), a Department of Defense (DoD) programme through the Uniformed Services University of the Health Sciences; National Institute of Allergy and Infectious Diseases, National Institutes of Health (NIH) [Y1-AI-5072] FX Support for this work was provided by the Infectious Disease Clinical Research Program (IDCRP), a Department of Defense (DoD) programme executed through the Uniformed Services University of the Health Sciences. This project has been funded in whole, or in part, with federal funds from the National Institute of Allergy and Infectious Diseases, National Institutes of Health (NIH), under Inter-Agency Agreement Y1-AI-5072. The content of this publication is the sole responsibility of the authors and does not necessarily reflect the views or policies of the NIH or the Department of Health and Human Services, the DoD or the Departments of the Army, Navy or Air Force. Mention of trade names, commercial products, or organizations does not imply endorsement by the US Government. NR 33 TC 2 Z9 2 U1 0 U2 3 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1464-2662 EI 1468-1293 J9 HIV MED JI HIV Med. PD MAR PY 2015 VL 16 IS 3 BP 161 EP 167 DI 10.1111/hiv.12189 PG 7 WC Infectious Diseases SC Infectious Diseases GA CB2CR UT WOS:000349434800003 PM 25586899 ER PT J AU Street, AE Gilman, SE Rosellini, AJ Stein, MB Bromet, EJ Cox, KL Colpe, LJ Fullerton, CS Gruber, MJ Heeringa, SG Lewandowski-Romps, L Little, RJA Naifeh, JA Nock, MK Sampson, NA Schoenbaum, M Ursano, RJ Zaslavsky, AM Kessler, RC AF Street, A. E. Gilman, S. E. Rosellini, A. J. Stein, M. B. Bromet, E. J. Cox, K. L. Colpe, L. J. Fullerton, C. S. Gruber, M. J. Heeringa, S. G. Lewandowski-Romps, L. Little, R. J. A. Naifeh, J. A. Nock, M. K. Sampson, N. A. Schoenbaum, M. Ursano, R. J. Zaslavsky, A. M. Kessler, R. C. CA Army STARRS Collaborators TI Understanding the elevated suicide risk of female soldiers during deployments SO PSYCHOLOGICAL MEDICINE LA English DT Article DE Army; Army STARRS; epidemiology; gender; military; risk factors; suicide ID SERVICEMEMBERS ARMY STARRS; MENTAL-HEALTH; GENDER-DIFFERENCES; OEF/OIF VETERANS; UNITED-STATES; US ARMY; MILITARY PERSONNEL; COMBAT DEPLOYMENT; SEXUAL-HARASSMENT; RESILIENCE AB Background. The Army Study to Assess Risk and Resilience in Servicemembers (Army STARRS) has found that the proportional elevation in the US Army enlisted soldier suicide rate during deployment (compared with the never-deployed or previously deployed) is significantly higher among women than men, raising the possibility of gender differences in the adverse psychological effects of deployment. Method. Person-month survival models based on a consolidated administrative database for active duty enlisted Regular Army soldiers in 2004-2009 (n = 975 057) were used to characterize the gender x deployment interaction predicting suicide. Four explanatory hypotheses were explored involving the proportion of females in each soldier's occupation, the proportion of same-gender soldiers in each soldier's unit, whether the soldier reported sexual assault victimization in the previous 12 months, and the soldier's pre-deployment history of treated mental/behavioral disorders. Results. The suicide rate of currently deployed women (14.0/100 000 person-years) was 3.1-3.5 times the rates of other (i.e. never-deployed/previously deployed) women. The suicide rate of currently deployed men (22.6/100 000 personyears) was 0.9-1.2 times the rates of other men. The adjusted (for time trends, sociodemographics, and Army career variables) female: male odds ratio comparing the suicide rates of currently deployed v. other women v. men was 2.8 (95% confidence interval 1.1-6.8), became 2.4 after excluding soldiers with Direct Combat Arms occupations, and remained elevated (in the range 1.9-2.8) after adjusting for the hypothesized explanatory variables. Conclusions. These results are valuable in excluding otherwise plausible hypotheses for the elevated suicide rate of deployed women and point to the importance of expanding future research on the psychological challenges of deployment for women. C1 [Street, A. E.] VA Boston Healthcare Syst, Natl Ctr PTSD, Boston, MA USA. [Street, A. E.] Boston Univ, Sch Med, Dept Psychiat, Boston, MA 02118 USA. [Gilman, S. E.] Harvard Univ, Sch Publ Hlth, Dept Social & Behav Sci, Boston, MA 02115 USA. [Gilman, S. E.] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA. [Rosellini, A. J.; Gruber, M. J.; Sampson, N. A.; Zaslavsky, A. M.; Kessler, R. C.] Harvard Univ, Sch Med, Dept Hlth Care Policy, Boston, MA 02115 USA. [Stein, M. B.] Univ Calif San Diego, Dept Psychiat, La Jolla, CA 92093 USA. [Stein, M. B.] Univ Calif San Diego, Dept Family & Prevent Med, La Jolla, CA 92093 USA. [Stein, M. B.] VA San Diego Healthcare Syst, San Diego, CA USA. [Bromet, E. J.] SUNY Stony Brook, Sch Med, Dept Psychiat, Stony Brook, NY 11794 USA. [Cox, K. L.] US Army Publ Hlth Command, Aberdeen Proving Ground, MD USA. [Colpe, L. J.] NIMH, Div Serv & Intervent Res, Bethesda, MD 20892 USA. [Fullerton, C. S.; Naifeh, J. A.; Ursano, R. J.] Uniformed Serv Univ Hlth Sci, Dept Psychiat, Sch Med, Ctr Study Traumat Stress, Bethesda, MD 20814 USA. [Heeringa, S. G.; Lewandowski-Romps, L.] Univ Michigan, Inst Social Res, Ann Arbor, MI USA. [Little, R. J. A.] Univ Michigan, Dept Biostat, Ann Arbor, MI 48109 USA. [Nock, M. K.] Harvard Univ, Dept Psychol, Cambridge, MA 02138 USA. [Schoenbaum, M.] NIMH, Off Sci Policy Planning & Commun, Bethesda, MD 20892 USA. RP Kessler, RC (reprint author), Harvard Univ, Sch Med, Dept Hlth Care Policy, 180 Longwood Ave, Boston, MA 02115 USA. EM kessler@hcp.med.harvard.edu RI Gilman, Stephen/E-7632-2010 OI Gilman, Stephen/0000-0002-8331-6419 FU Department of the Army; US Department of Health and Human Services, National Institutes of Health, National Institute of Mental Health (NIH/NIMH) [U01MH087981] FX Army STARRS was sponsored by the Department of the Army and funded under cooperative agreement number U01MH087981 with the US Department of Health and Human Services, National Institutes of Health, National Institute of Mental Health (NIH/NIMH). The contents are solely the responsibility of the authors and do not necessarily represent the views of the Department of Health and Human Services, NIMH, the Department of the Army, or the DoD. Co-principal investigators are: Robert J. Ursano, MD (Uniformed Services University of the Health Sciences) and Murray B. Stein, MD, MPH (University of California San Diego and VA San Diego Healthcare System). Site principal investigators are: Steven Heeringa, PhD (University of Michigan) and Ronald C. Kessler, PhD (Harvard Medical School). NIMH collaborating scientists are: Lisa J. Colpe, PhD, MPH and Michael Schoenbaum, PhD. Army liaisons/consultants are: Col. Steven Cersovsky, MD, MPH (US Army Public Health Command; USAPHC); Kenneth Cox, MD, MPH (USAPHC). Other team members: Pablo A. Aliaga, MA (Uniformed Services University of the Health Sciences); Col. David M. Benedek, MD (Uniformed Services University of the Health Sciences); Susan Borja, PhD (NIMH); Gregory G. Brown, PhD (University of California San Diego); Laura Campbell-Sills, PhD (University of California San Diego); Catherine L. Dempsey, PhD, MPH (Uniformed Services University of the Health Sciences); Richard Frank, PhD (Harvard Medical School); Carol S. Fullerton, PhD (Uniformed Services University of the Health Sciences); Nancy Gebler, MA (University of Michigan); Robert K. Gifford, PhD (Uniformed Services University of the Health Sciences); Stephen E. Gilman, ScD (Harvard School of Public Health); Marjan G. Holloway, PhD (Uniformed Services University of the Health Sciences); Paul E. Hurwitz, MPH (Uniformed Services University of the Health Sciences); Sonia Jain, PhD (University of California San Diego); Tzu-Cheg Kao, PhD (Uniformed Services University of the Health Sciences); Karestan C. Koenen, PhD (Columbia University); Lisa Lewandowski-Romps, PhD (University of Michigan); Holly Herberman Mash, PhD (Uniformed Services University of the Health Sciences); James E. McCarroll, PhD, MPH (Uniformed Services University of the Health Sciences); Katie A. McLaughlin, PhD (Harvard Medical School); James A. Naifeh, PhD (Uniformed Services University of the Health Sciences); Matthew K. Nock, PhD (Harvard University); Rema Raman, PhD (University of California San Diego); Sherri Rose, PhD (Harvard Medical School); Anthony Joseph Rosellini, PhD (Harvard Medical School); Nancy A. Sampson, BA (Harvard Medical School); LCDR Patcho Santiago, MD, MPH (Uniformed Services University of the Health Sciences); Michaelle Scanlon, MBA (NIMH); Jordan Smoller, MD, ScD (Harvard Medical School); Michael L. Thomas, PhD (University of California San Diego); Patti L. Vegella, MS, MA (Uniformed Services University of the Health Sciences); Christina Wassel, PhD (University of Pittsburgh); and Alan M. Zaslavsky, PhD (Harvard Medical School). A complete list of Army STARRS publications can be found at http://www.ARMYSTARRS.org. As a cooperative agreement, scientists employed by NIMH (L. J. Colpe and M. Schoenbaum) and Army liaisons/consultants (Col. Steven Cersovsky, MD, MPH USAPHC and Kenneth Cox, MD, MPH USAPHC) collaborated to develop the study protocol and data collection instruments, supervise data collection, plan and supervise data analyses, interpret results, and prepare reports.; Although a draft of this manuscript was submitted to the Army and NIMH for review and comment prior to submission, this was with the understanding that comments would be no more than advisory. NR 46 TC 9 Z9 9 U1 4 U2 18 PU CAMBRIDGE UNIV PRESS PI NEW YORK PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA SN 0033-2917 EI 1469-8978 J9 PSYCHOL MED JI Psychol. Med. PD MAR PY 2015 VL 45 IS 4 BP 717 EP 726 DI 10.1017/S003329171400258X PG 10 WC Psychology, Clinical; Psychiatry; Psychology SC Psychology; Psychiatry GA CB4SR UT WOS:000349618900004 PM 25359554 ER PT J AU Lieberman, HR Thompson, LA Caruso, CM Niro, PJ Mahoney, CR McClung, JP Caron, GR AF Lieberman, Harris R. Thompson, Lauren A. Caruso, Christina M. Niro, Philip J. Mahoney, Caroline R. McClung, James P. Caron, Gregory R. TI The catecholamine neurotransmitter precursor tyrosine increases anger during exposure to severe psychological stress SO PSYCHOPHARMACOLOGY LA English DT Article DE Mood; Cortisol; Amino acid; Norepinephrine; Dopamine; SERE; Interrogation; Military ID COGNITIVE PERFORMANCE; SALIVARY CORTISOL; NEUROPEPTIDE-Y; UNCONTROLLABLE STRESS; SLEEP-DEPRIVATION; MOTOR-PERFORMANCE; ADRENAL-FUNCTION; WORKING-MEMORY; COLD-EXPOSURE; MOOD AB Acute stress produces behavioral and physiological changes modulated by central catecholamines (CA). Stress increases CA activity, and depletion of CA stores reduces responses to stress. Increasing CA activity by administration of the dietary amino acid CA precursor tyrosine may increase responsiveness to stress. This study determined whether tyrosine enhances the ability of humans to respond to severe stress. Severe psychological stress was generated during training at Survival, Evasion, Resistance, and Escape (SERE) School. The acute stressor consisted of two mock interrogations conducted during several days of simulated captivity. Seventy-eight healthy male and female military personnel participated in this double-blind, between-subjects study, in which they received either tyrosine (300 mg/kg, N = 36) or placebo (N = 36). Tyrosine (or placebo) was administered in food bars in two doses of 150 mg/kg each approximately 60 min before each mock interrogation. Mood (Profile of Mood States), saliva cortisol, and heart rate (HR) were assessed prior to stress exposure during a week of academic training preceding mock captivity and immediately following the mock interrogations. The severe stress produced robust effects on mood (i.e., increased tension, depression, anger, fatigue, vigor, and confusion; p < .001), cortisol, and HR (p < .001). Tyrosine increased anger (p = .002, ANOVA treatment condition by test session interaction) during stress but had no other effects. Tyrosine did not alter most subjective or physiological responses to severe acute stress, but it increased ratings of anger. The modest increase in anger may be an adaptive emotional response in stressful environments. C1 [Lieberman, Harris R.; Thompson, Lauren A.; Caruso, Christina M.; Niro, Philip J.; McClung, James P.] US Army Res Inst Environm Med, Mil Nutr Div, Natick, MA 01760 USA. [Mahoney, Caroline R.] US Army Natick Soldier Res Dev & Engn Ctr, Natick, MA 01760 USA. [Caron, Gregory R.] SERE EAST, Ctr Secur Forces, Brunswick, ME 04011 USA. RP Lieberman, HR (reprint author), US Army Res Inst Environm Med, Mil Nutr Div, Kansas St, Natick, MA 01760 USA. EM harris.lieberman@us.army.mil FU US Army Medical Research and Materiel Command FX The authors wish to acknowledge the volunteers that participated in the present study as well as the staff at the US Navy SERE School in Brunswick, ME, for allowing access to their students and facilities. The authors would also like to thank Jack Briggs and Paul Maguire for their assistance with the development and preparation of the food bars used in this study and Phil Karl, Tony Rogers, Mike Stanger, and Brooke Green for their assistance with data collection. The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the US Army or Department of Defense. Human subjects participated in these studies after giving their free and informed voluntary consent. The investigators have adhered to the policies for the protection of human subjects as prescribed in Army Regulation 70-25, and the research was conducted in adherence with the provisions of 32 CFR Part 219. Citations of commercial organizations and trade names in this report do not constitute an official US Department of the Army endorsement or approval of the products or services of these organizations. This study was supported by the US Army Medical Research and Materiel Command. NR 64 TC 2 Z9 2 U1 1 U2 11 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0033-3158 EI 1432-2072 J9 PSYCHOPHARMACOLOGY JI Psychopharmacology PD MAR PY 2015 VL 232 IS 5 BP 943 EP 951 DI 10.1007/s00213-014-3727-7 PG 9 WC Neurosciences; Pharmacology & Pharmacy; Psychiatry SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry GA CB1HD UT WOS:000349377000011 PM 25220844 ER PT J AU Muhandiramge, D Udeoji, DU Biswas, OS Bharadwaj, P Black, LZ Mulholland, KA Moschella, C Schwarz, ER AF Muhandiramge, Demian Udeoji, Dioma U. Biswas, Olivia S. Bharadwaj, Parag Black, Leila Z. Mulholland, Karen Angelus Moschella, Concetta Schwarz, Ernst R. TI Palliative care issues in heart transplant candidates SO CURRENT OPINION IN SUPPORTIVE AND PALLIATIVE CARE LA English DT Review DE chronic heart failure; heart transplant; palliative care; quality of life ID QUALITY-OF-LIFE; CONTROLLED-TRIAL; FAILURE PATIENTS; DISEASE; BREATHLESSNESS; ASSOCIATION; PERCEPTIONS; MANAGEMENT; SERVICES; PAIN AB Purpose of review Heart failure is a serious condition and equivalent to malignant disease in terms of symptoms burden and mortality. Presently, only a comparatively small number of heart failure patients receive specialized palliative care. A literature search was conducted with the terms, palliative care and heart failure, using the electronic databases of PubMed and MEDLINE. Recent findings Nine-hundred and five articles were reviewed and of those, 78 articles discussed clinical trials in palliative care and heart failure. A complex set of management tools and strategies were used and recommended, including but not limited to lifestyle modification, exercise programs, pain and sleep disorder management, and support in end-of-life care. Limited data are available of using palliative care in heart transplant candidates prior to transplant surgery. Summary Diminishing quality of life prevails throughout the course of chronic heart failure. Therefore, palliative care should be integrated into heart failure management. Heart transplant candidates may benefit from early palliative care involvement independent of the clinical course and outcome. Because of gaps in current scientific literature on palliative care, end-of-life care, and hospice care and the services rendered, further research is necessary to encourage healthcare professionals to introduce palliative care as an early resource in chronic disease progression. C1 [Muhandiramge, Demian; Udeoji, Dioma U.; Biswas, Olivia S.; Bharadwaj, Parag; Black, Leila Z.; Mulholland, Karen Angelus; Moschella, Concetta; Schwarz, Ernst R.] DSMI, Beverly Hills, CA USA. [Muhandiramge, Demian; Udeoji, Dioma U.; Biswas, Olivia S.; Bharadwaj, Parag; Black, Leila Z.; Mulholland, Karen Angelus; Moschella, Concetta; Schwarz, Ernst R.] Cedars Sinai Med Ctr, Los Angeles, CA 90048 USA. [Muhandiramge, Demian; Udeoji, Dioma U.; Biswas, Olivia S.; Bharadwaj, Parag; Black, Leila Z.; Mulholland, Karen Angelus; Moschella, Concetta; Schwarz, Ernst R.] St Joseph Hosp, USA, Chicago, IL USA. RP Schwarz, ER (reprint author), Cedars Sinai Med Ctr, 8631 West Third St,Ste 1017 East Tower, Los Angeles, CA 90048 USA. EM dr.ernstschwarz@gmail.com NR 64 TC 2 Z9 2 U1 0 U2 6 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1751-4258 EI 1751-4266 J9 CURR OPIN SUPPORT PA JI Curr. Opin Support Palliat. Car. PD MAR PY 2015 VL 9 IS 1 BP 5 EP 13 DI 10.1097/SPC.0000000000000112 PG 9 WC Health Care Sciences & Services SC Health Care Sciences & Services GA CA3UF UT WOS:000348831600002 PM 25588206 ER PT J AU Suedel, BC Clarke, JU Wilkens, J Lutz, CH Clarke, DG AF Suedel, Burton C. Clarke, Joan U. Wilkens, Justin Lutz, Charles H. Clarke, Douglas G. TI The Effects of a Simulated Suspended Sediment Plume on Eastern Oyster (Crassostrea virginica) Survival, Growth, and Condition SO ESTUARIES AND COASTS LA English DT Article DE Toxicity; Environmental windows; Dredging; James River; Condition index ID SOFT-SHELL CLAM; MERCENARIA-MERCENARIA; VALVE GAPE; FOOD AVAILABILITY; FEEDING-BEHAVIOR; BIVALVE BEHAVIOR; WATER-FLOW; MUSSELS; PREDATION; TRANSPORT AB Bottom sediments are resuspended into the water column during dredging operations. These resuspended sediments are an often cited concern used to justify restrictions applied to dredging schedules in many areas of the USA. One example of a temporal restriction, commonly referred to as an environmental window, involves dredging schedules in the James River, Virginia, because of potential impacts on the eastern oyster (Crassostrea virginica Gmelin). Yet, effects' data are lacking to understand the effects of suspended sediments to C. virginica. To address this data gap, we performed a laboratory study mimicking sediment resuspension during annual dredging operations in the James River. Field-collected oysters were exposed for 7 days under flow-through conditions to 0, 100, 250, and 500-mg/L total suspended solids (TSS) in a unique exposure system where oyster movements could be electronically monitored. Endpoints analyzed were survival, percent of time open, total number of shell movements, weight change, and condition index. Data indicated no significant effects of suspended sediment on these endpoints after 7 days of exposure. Weight change in oysters attached vertically to monitor their movements was significantly less than in oysters not monitored in every treatment. No significant differences in condition index, an indicator of oyster growth sensitive to environmental pollutants, were observed among treatments measured 30 days postexposure. Correlations performed for each treatment among monitored oyster endpoints found significant negative associations between number of movements and percent open in the 100, 250, and 500-mg/L TSS treatments and in all treatments combined. These data will help reduce the uncertainty surrounding the effects of suspended sediments on C. virginica. C1 [Suedel, Burton C.; Clarke, Joan U.; Wilkens, Justin; Lutz, Charles H.; Clarke, Douglas G.] US Army Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA. RP Suedel, BC (reprint author), US Army Engineer Res & Dev Ctr, Environm Lab, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM burton.suedel@usace.army.mil FU Dredging Operations and Environmental Research Program FX We thank Tom Kellum of W.E. Kellum, Inc. for the field collection of the oysters. We thank Roger Mann of the Virginia Institute of Marine Sciences (VIMS) for reviewing an earlier version of the paper. We thank Sarah O'Haire of the Norfolk District Corps of Engineers for coordinating sediment collection and Melissa Southworth of the VIMS for providing holding facilities and for performing condition index measurements. This research was funded by the Dredging Operations and Environmental Research Program, Todd Bridges, Program Manager. Permission was granted by the Chief of Engineers to publish this material. NR 69 TC 1 Z9 1 U1 3 U2 24 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1559-2723 EI 1559-2731 J9 ESTUAR COAST JI Estuaries Coasts PD MAR PY 2015 VL 38 IS 2 BP 578 EP 589 DI 10.1007/s12237-014-9835-0 PG 12 WC Environmental Sciences; Marine & Freshwater Biology SC Environmental Sciences & Ecology; Marine & Freshwater Biology GA CA3EN UT WOS:000348789300014 ER PT J AU Salzer, WL Jones, TL Devidas, M Dreyer, ZE Gore, L Winick, NJ Sung, L Raetz, E Loh, ML Wang, CY De Lorenzo, P Valsecchi, MG Pieters, R Carroll, WL Hunger, SP Hilden, JM Brown, P AF Salzer, Wanda L. Jones, Tamekia L. Devidas, Meenakshi Dreyer, ZoAnn E. Gore, Lia Winick, Naomi J. Sung, Lillian Raetz, Elizabeth Loh, Mignon L. Wang, Cindy Y. De Lorenzo, Paola Valsecchi, Maria Grazia Pieters, Rob Carroll, William L. Hunger, Stephen P. Hilden, Joanne M. Brown, Patrick TI Decreased Induction Morbidity and Mortality Following Modification to Induction Therapy in Infants With Acute Lymphoblastic Leukemia Enrolled on AALL0631: A Report From the Children's Oncology Group SO PEDIATRIC BLOOD & CANCER LA English DT Article DE infant acute lymphoblastic leukemia; mortality ID FARBER-CANCER-INSTITUTE; STANDARD-RISK; CHILDHOOD-LEUKEMIA; CONSECUTIVE TRIALS; PROGNOSTIC-FACTORS; IMPROVED SURVIVAL; RANDOMIZED-TRIAL; DEXAMETHASONE; EXPERIENCE; PROTOCOL AB BackgroundInfants with acute lymphoblastic leukemia (ALL) have a poor prognosis. Intensification of therapy has resulted in fewer relapses but increased early deaths, resulting in failure to improve survival. ProcedureAALL0631 is a Phase 3 study for infants (<366 days of age) with newly diagnosed ALL. Induction initially (Cohort 1) consisted of 3 weeks of therapy based on COG P9407. Due to excessive early mortality, induction was amended to a less intensive 5 weeks of therapy based on Interfant-99. Additionally, enhanced supportive care guidelines were incorporated with hospitalization during induction until evidence of marrow recovery and recommendations for prevention/treatment of infections (Cohort 2). ResultsInduction mortality was significantly lower for patients in Cohort 2 (2/123, 1.6%) versus Cohort 1 (4/26, 15.4%; P=0.009). All induction deaths were infection related except one due to progressive disease (Cohort 2). Sterile site infections were lower for patients in Cohort 2 (24/123, 19.5%) versus Cohort 1 (15/26, 57.7%; P=0.0002), with a significantly lower rate of Gram positive infections during induction for patients in Cohort 2, P=0.0002. No clinically significant differences in grades 3-5 non-infectious toxicities were observed between the two cohorts. Higher complete response rates were observed at end induction intensification for Cohort 2 (week 9, 94/100, 94%) versus Cohort 1 (week 7, 17/25, 68%; P=0.0.0012). ConclusionDe-intensification of induction therapy and enhanced supportive care guidelines significantly decreased induction mortality and sterile site infections, without decreasing complete remission rates. Pediatr Blood Cancer 2015;62:414-418. (c) 2014 Wiley Periodicals, Inc. C1 [Salzer, Wanda L.] US Army Med Res & Mat Command, Ft Detrick, MD USA. [Jones, Tamekia L.; Devidas, Meenakshi] Univ Florida, Coll Med, Dept Biostat, Gainesville, FL USA. [Jones, Tamekia L.; Devidas, Meenakshi] Univ Florida, Coll Publ Hlth & Hlth Profess, Dept Biostat, Gainesville, FL USA. [Dreyer, ZoAnn E.] Baylor Coll Med, Texas Childrens Canc Ctr, Houston, TX 77030 USA. [Gore, Lia; Hunger, Stephen P.; Hilden, Joanne M.] Univ Colorado Sch Med, Childrens Hosp Colorado, Aurora, CO USA. [Winick, Naomi J.] Univ Texas Southwestern Sch Med, Div Pediat Hematol Oncol, Dallas, TX USA. [Sung, Lillian] Hosp Sick Children, Div Haematol Oncol, Toronto, ON M5G 1X8, Canada. [Raetz, Elizabeth] Univ Utah, Dept Pediat, Salt Lake City, UT USA. [Raetz, Elizabeth] Univ Utah, Huntsman Canc Inst, Salt Lake City, UT USA. [Loh, Mignon L.] Univ Calif San Francisco, Dept Pediat, San Francisco, CA USA. [Wang, Cindy Y.] Univ Florida, Childrens Oncol Grp, Stat & Data Ctr, Gainesville, FL USA. [De Lorenzo, Paola] Univ Milano Bicocca, Interfant Trial Data Ctr, Pediat Clin, Monza, Italy. [De Lorenzo, Paola; Valsecchi, Maria Grazia] Univ Milano Bicocca, Dept Hlth Sci, Monza, Italy. [Pieters, Rob] Erasmus MC Sophia Childrens Hosp, Princess Maxima Ctr Pediat Oncol, Rotterdam, Netherlands. [Carroll, William L.] New York Univ Canc Inst, New York, NY USA. [Brown, Patrick] Johns Hopkins Univ, Baltimore, MD USA. RP Salzer, WL (reprint author), 1077 Patchel St, Ft Detrick, MD 21702 USA. EM wanda.l.salzer.mil@mail.mil FU National Institutes of Health [CA13539, CA98543] FX Grant sponsor: National Institutes of Health; Grant number: CA13539 and CA98543 NR 25 TC 3 Z9 4 U1 1 U2 3 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1545-5009 EI 1545-5017 J9 PEDIATR BLOOD CANCER JI Pediatr. Blood Cancer PD MAR PY 2015 VL 62 IS 3 BP 414 EP 418 DI 10.1002/pbc.25311 PG 5 WC Oncology; Hematology; Pediatrics SC Oncology; Hematology; Pediatrics GA CA4BU UT WOS:000348850100008 PM 25407157 ER PT J AU Chambers, C Luo, CY Tong, M Yang, YR Saxena, A AF Chambers, Carolyn Luo, Chunyuan Tong, Min Yang, Yerie Saxena, Ashima TI Probing the role of amino acids in oxime-mediated reactivation of nerve agent-inhibited human acetylcholinesterase SO TOXICOLOGY IN VITRO LA English DT Article DE Human AChE mutants; Nerve agents; Oximes; Reactivation; In vitro study; Site-directed mutagenesis ID ORGANOPHOSPHORUS COMPOUNDS; CHOLINESTERASES; MECHANISM; VARIANTS; RESIDUES; KINETICS; BIOLOGY; HI-6 AB In this study, we employed site-directed mutagenesis to understand the role of amino acids in the gorge in oxime-induced reactivation of nerve agent-inhibited human (Hu) acetylcholinesterase (AChE). The organophosphorus (OP) nerve agents studied included GA (tabun), GB (sarin), GF (cyclosarin), VX, and VR. The kinetics of reactivation were examined using both the mono-pyridinium oxime 2-PAM and bis-pyridinium oximes MMB4, HI-6, and HLo-7. The second-order reactivation rate constants were used to compare reactivation of nerve agent-inhibited wild-type (WT) and mutant enzymes. Residues including Y72, Y124 and W286 were found to play important roles in reactivation by bis-pyridinium, but not by mono-pyridinium oximes. Residue Y124 also was found to play a key role in reactivation by HI-6 and HLo-7, while E202 was important for reactivation by all oximes. Residue substitutions of F295 by Leu and Y337 by Ala showed enhanced reactivation by bis-pyridinium oximes MMB4, HI-6, and HLo-7, possibly by providing more accessibility of the OP moiety associated at the active-site serine to the oxime. These results are similar to those observed previously with bovine AChE and demonstrate that there is significant similarity between human and bovine AChEs with regard to oxime reactivation. Published by Elsevier Ltd. C1 [Chambers, Carolyn; Luo, Chunyuan; Tong, Min; Yang, Yerie; Saxena, Ashima] Walter Reed Army Inst Res, Div Biochem, Silver Spring, MD 20910 USA. [Saxena, Ashima] US Mil, HIV Res Program, Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. RP Saxena, A (reprint author), US Mil, HIV Res Program, Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. EM ashima.saxena@us.army.mil FU Defense Threat Reduction Agency-Joint Science and Technology Office, Medical Science and Technology Division FX We wish to thank Dr. Oksana Lockridge of the University of Nebraska for providing the plasmid carrying the full length cDNA sequence of Hu AChE, and Richard Sweeney for the schematic representation of AChE. The views expressed in this manuscript are those of the author(s) and do not reflect the official policy of the Department of Army, Department of Defense, or the U.S. Government. This research was supported by the Defense Threat Reduction Agency-Joint Science and Technology Office, Medical Science and Technology Division. NR 34 TC 4 Z9 4 U1 3 U2 23 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0887-2333 J9 TOXICOL IN VITRO JI Toxicol. Vitro PD MAR PY 2015 VL 29 IS 2 BP 408 EP 414 DI 10.1016/j.tiv.2014.11.001 PG 7 WC Toxicology SC Toxicology GA CA0RW UT WOS:000348625200017 PM 25451328 ER PT J AU Dubick, MA Barr, JL Keen, CL Atkins, JL AF Dubick, Michael A. Barr, Johnny L. Keen, Carl L. Atkins, James L. TI Ceruloplasmin and Hypoferremia: Studies in Burn and Non-Burn Trauma Patients SO ANTIOXIDANTS LA English DT Article DE ceruloplasmin; ferroxidase; iron status; oxidant stress; burn; trauma ID RECOMBINANT-HUMAN-ERYTHROPOIETIN; RESPIRATORY-DISTRESS-SYNDROME; PARTIAL THROMBOPLASTIN TIME; ACUTE LUNG INJURY; SMOKE-INHALATION; IRON-METABOLISM; INFLAMMATORY RESPONSE; HYPERCOAGULABLE STATE; HEMORRHAGIC-SHOCK; PROTHROMBIN TIME AB Objective: Normal iron handling appears to be disrupted in critically ill patients leading to hypoferremia that may contribute to systemic inflammation. Ceruloplasmin (Cp), an acute phase reactant protein that can convert ferrous iron to its less reactive ferric form facilitating binding to ferritin, has ferroxidase activity that is important to iron handling. Genetic absence of Cp decreases iron export resulting in iron accumulation in many organs. The objective of this study was to characterize iron metabolism and Cp activity in burn and non-burn trauma patients to determine if changes in Cp activity are a potential contributor to the observed hypoferremia. Material and Methods: Under Brooke Army Medical Center Institutional Review Board approved protocols, serum or plasma was collected from burn and non-burn trauma patients on admission to the ICU and at times up to 14 days and measured for indices of iron status, Cp protein and oxidase activity and cytokines. Results: Burn patients showed evidence of anemia and normal or elevated ferritin levels. Plasma Cp oxidase activity in burn and trauma patients were markedly lower than controls on admission and increased to control levels by day 3, particularly in burn patients. Plasma cytokines were elevated throughout the 14 days study along with evidence of an oxidative stress. No significant differences in soluble transferrin receptor were noted among groups on admission, but levels in burn patients were lower than controls for the first 5 days after injury. Conclusion: This study further established the hypoferremia and inflammation associated with burns and trauma. To our knowledge, this is the first study to show an early decrease in Cp oxidase activity in burn and non-burn trauma patients. The results support the hypothesis that transient loss of Cp activity contributes to hypoferremia and inflammation. Further studies are warranted to determine if decreased Cp activity increases the risk of iron-induced injury following therapeutic interventions such as transfusions with blood that has undergone prolonged storage in trauma resuscitation. C1 [Dubick, Michael A.; Barr, Johnny L.] US Army, Inst Surg Res, 3698 Chambers Pass, JBSA Ft Sam Houston, TX 78234 USA. [Keen, Carl L.] Univ Calif Davis, Dept Nutr & Internal Med, Davis, CA 95616 USA. [Atkins, James L.] Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. RP Dubick, MA (reprint author), US Army, Inst Surg Res, 3698 Chambers Pass, JBSA Ft Sam Houston, TX 78234 USA. EM michael.a.dubick.civ@mail.mil; Johnny.l.barr.civ@mail.mil; clkeen@ucdavis.edu; jim.atkins.w@gmail.com NR 57 TC 0 Z9 0 U1 1 U2 1 PU MDPI AG PI BASEL PA POSTFACH, CH-4005 BASEL, SWITZERLAND SN 2076-3921 J9 ANTIOXIDANTS JI Antioxidants PD MAR PY 2015 VL 4 IS 1 BP 153 EP 169 DI 10.3390/antiox4010153 PG 17 WC Chemistry, Medicinal SC Pharmacology & Pharmacy GA DG0XO UT WOS:000371789500009 PM 26785343 ER PT J AU Kearney, SP Mosca, VS AF Kearney, Sean P. Mosca, Vincent S. TI Selective hemiepiphyseodesis for patellar instability with associated genu valgum SO JOURNAL OF ORTHOPAEDICS LA English DT Article DE Patellar instability; Genu valgum; Epiphyseodesis; Guided growth ID MEDIAL PATELLOFEMORAL LIGAMENT; DISLOCATION; CHILDREN; RECONSTRUCTION; KNEE; REALIGNMENT; VARUM; PAIN AB Background/Aims: Patellar instability limits activity and promotes arthritis. Correcting genu valgum with selective hemiepiphyseodesis can treat patellar instability. Methods: We retrospectively reviewed 26 knees with patellar instability and associated genu valgum that underwent hemiepiphyseodesis. Results: Average anatomic lateral distal femoral angle (aLDFA) significantly corrected. Symptoms improved in all patients. All competitive athletes returned to sports. One complication occurred. Conclusions: In genu valgum, the patella seeks an abnormal mechanical axis, resulting in patellar instability. By correcting the mechanical axis with hemiepiphyseodesis, patellar instability symptoms improve and patients return to sports. Complications are rare. Selective hemiepiphyseodesis is recommended when treating patellar instability with associated genu valgum. Copyright (C) 2015, Professor P K Surendran Memorial Education Foundation. Publishing Services by Reed Elsevier India Pvt. Ltd. All rights reserved. C1 [Kearney, Sean P.] Womack Army Med Ctr, Dept Orthoped & Rehabil, Ft Bragg, NC 28310 USA. [Mosca, Vincent S.] Seattle Childrens Hosp, Orthopaed Adm W 7706, Seattle, WA 98105 USA. RP Kearney, SP (reprint author), Womack Army Med Ctr, Dept Orthoped & Rehabil, Ft Bragg, NC 28310 USA. EM spkearney1@gmail.com NR 29 TC 0 Z9 0 U1 0 U2 1 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0972-978X J9 J ORTHOP JI J. Orthop. PD MAR PY 2015 VL 12 IS 1 BP 17 EP 22 DI 10.1016/j.jor.2015.01.005 PG 6 WC Orthopedics SC Orthopedics GA DY9DX UT WOS:000385434900004 PM 25829756 ER PT J AU Walling, K AF Walling, Karl TI American Force: Dangers, Delusions, and Dilemmas of National Security SO NAVAL WAR COLLEGE REVIEW LA English DT Book Review C1 [Walling, Karl] US Army, Adelphi, MD USA. [Walling, Karl] Naval War Coll, Newport, RI USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU US NAVAL WAR COLL PI NEWPORT PA 686 CUSHING RD, NEWPORT, RI 02841 USA SN 0028-1484 J9 NAV WAR COLL REV JI Nav. War Coll. Rev. PD SPR PY 2015 VL 68 IS 2 BP 131 EP 133 PG 3 WC International Relations SC International Relations GA DP3ZM UT WOS:000378435000010 ER PT J AU Fischer, RA Valente, JJ Guilfoyle, MP AF Fischer, Richard A. Valente, Jonathon J. Guilfoyle, Michael P. TI SPRING MIGRANT USE OF NATIVE AND SALTCEDAR-DOMINATED RIPARIAN AREAS ALONG THE LOWER COLORADO RIVER IN ARIZONA SO SOUTHWESTERN NATURALIST LA English DT Article ID SOUTHWESTERN UNITED-STATES; MIGRATORY SONGBIRD; LANDBIRD MIGRATION; STOPOVER HABITAT; TAMARIX; BIRDS; PHYSIOGNOMY; COMMUNITIES; POPULATIONS; FLORISTICS AB Riparian systems in the western United States provide essential stopover habitat to en-route migrant birds, and there is concern that the invasion and dominance of saltcedar (Tamarix) in many areas may inhibit use by some species. However, evidence from recent studies is challenging the widely held belief that invasive plants universally reduce habitat quality. Moreover, where many studies have compared avian use of riparian habitats dominated by saltcedar with those comprised primarily of native trees, few have investigated how birds use shrub communities, which are becoming more prevalent in western riparian zones because of widespread hydrologic modifications. We compared spring migrant use of 125-m sections of riparian habitat dominated by five different habitat types in southwestern Arizona in 2006 and 2007. We found that migrant abundance, species richness, and community assemblages were all influenced by the composition of riparian vegetation. Habitats completely dominated by saltcedar supported fewer migrants and migrant species than any other habitat type, but the presence of small amounts of native vegetation as a part of the overall riparian plant community greatly bolstered habitat use. Habitats dominated by native shrubs tended to support the greatest total migrant abundance, total species richness, and abundance of many individual species. Our findings suggest that riparian areas dominated by saltcedar are avoided by many western migrant species and have relatively low value as stopover habitat. In places where this species is a predominant component of the riparian plant community, restoration of at least a portion of native riparian vegetation may be effective for encouraging use by stopover migrants. C1 [Fischer, Richard A.; Valente, Jonathon J.; Guilfoyle, Michael P.] US Army, Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA. RP Valente, JJ (reprint author), Oregon State Univ, Dept Forest Ecosyst & Soc, Corvallis, OR 97333 USA. EM Jonathon.J.Valente@gmail.com FU Department of Defense's Strategic Environmental Research and Development Program [RC-1439] FX We thank S.A. Gauthreaux Jr. for assistance in analyzing radar data, M. D. Kaller for providing advice regarding statistical analyses, and N. Volpe and G. Emmanuelli for translating the abstract. We also thank M. T. Auer, C. Cordy, A. Larned, and J. McCabe for their assistance in the field. This research was funded by the Department of Defense's Strategic Environmental Research and Development Program as project RC-1439. NR 37 TC 0 Z9 0 U1 3 U2 7 PU SOUTHWESTERN ASSOC NATURALISTS PI SAN MARCOS PA SOUTHWEST TEXAS STATE UNIV, DEPT BIOLOGY, 601 UNIVERSITY DR, SAN MARCOS, TX 78666 USA SN 0038-4909 EI 1943-6262 J9 SOUTHWEST NAT JI Southw. Natural. PD MAR PY 2015 VL 60 IS 1 BP 6 EP 14 DI 10.1894/MCG-06.1 PG 9 WC Biodiversity Conservation; Ecology SC Biodiversity & Conservation; Environmental Sciences & Ecology GA DE8NQ UT WOS:000370893200002 ER PT J AU Schill, JF Holthoff, EL Pellegrino, PM AF Schill, John F. Holthoff, Ellen L. Pellegrino, Paul M. TI Predicting the Resonant Frequency of Photoacoustic Cells With Side Branches SO IEEE SENSORS JOURNAL LA English DT Article DE Acoustic resonance; photoacoustic cell; photoacoustic spectroscopy; cylindrical tube with side branch ID QUANTUM CASCADE LASER; SPECTROSCOPY AB A theoretical method for predicting the resonant frequencies of acoustic resonators with side branches is introduced. This method is successfully extended to microelectromechanical-scale photoacoustic cell resonators with complex side branch structures. Resonant frequencies are calculated to within a few percent of experimental results. The effect of the side branch hole diameter on the resonant frequency is also demonstrated. C1 [Schill, John F.; Holthoff, Ellen L.; Pellegrino, Paul M.] US Army Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA. RP Schill, JF (reprint author), US Army Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA. EM john.f.schill.civ@mail.mil; ellen.l.holthoff.civ@mail.mil; paul.m.pellegrino.civ@mail.mil NR 8 TC 3 Z9 3 U1 0 U2 19 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1530-437X EI 1558-1748 J9 IEEE SENS J JI IEEE Sens. J. PD MAR PY 2015 VL 15 IS 3 BP 1336 EP 1337 DI 10.1109/JSEN.2014.2369254 PG 2 WC Engineering, Electrical & Electronic; Instruments & Instrumentation; Physics, Applied SC Engineering; Instruments & Instrumentation; Physics GA AX1ZS UT WOS:000346743600004 ER PT J AU Wang, ZY Nasrabadi, NM Huang, TS AF Wang, Zhangyang Nasrabadi, Nasser M. Huang, Thomas S. TI Semisupervised Hyperspectral Classification Using Task-Driven Dictionary Learning With Laplacian Regularization SO IEEE TRANSACTIONS ON GEOSCIENCE AND REMOTE SENSING LA English DT Article DE Bilevel optimization; hyperspectral image classification; semisupervised learning; sparse coding; spatial Laplacian regularization; task-driven dictionary learning ID SUPPORT VECTOR MACHINES; IMAGE CLASSIFICATION; SPARSE-REPRESENTATION; K-SVD AB We present a semisupervised method for single-pixel classification of hyperspectral images. The proposed method is designed to address the special problematic characteristics of hyperspectral images, namely, high dimensionality of hyperspectral pixels, lack of labeled samples, and spatial variability of spectral signatures. To alleviate these problems, the proposed method features the following components. First, being a semisupervised approach, it exploits the wealth of unlabeled samples in the image by evaluating the confidence probability of the predicted labels, for each unlabeled sample. Second, we propose to jointly optimize the classifier parameters and the dictionary atoms by a task-driven formulation, to ensure that the learned features (sparse codes) are optimal for the trained classifier. Finally, it incorporates spatial information through adding a Laplacian smoothness regularization to the output of the classifier, rather than the sparse codes, making the spatial constraint more flexible. The proposed method is compared with a few comparable methods for classification of several popular data sets, and it produces significantly better classification results. C1 [Wang, Zhangyang; Huang, Thomas S.] Univ Illinois, Dept Elect & Comp Engn, Beckman Inst, Champaign, IL 61801 USA. [Nasrabadi, Nasser M.] US Army Res Lab, Adelphi, MD 20783 USA. RP Wang, ZY (reprint author), Univ Illinois, Dept Elect & Comp Engn, Beckman Inst, Champaign, IL 61801 USA. FU U.S. Army Research Laboratory; U.S. Army Research Office [W911NF-09-1-0383] FX The work was supported by the U.S. Army Research Laboratory and the U.S. Army Research Office under Grant W911NF-09-1-0383. NR 41 TC 6 Z9 6 U1 1 U2 44 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0196-2892 EI 1558-0644 J9 IEEE T GEOSCI REMOTE JI IEEE Trans. Geosci. Remote Sensing PD MAR PY 2015 VL 53 IS 3 BP 1161 EP 1173 DI 10.1109/TGRS.2014.2335177 PG 13 WC Geochemistry & Geophysics; Engineering, Electrical & Electronic; Remote Sensing; Imaging Science & Photographic Technology SC Geochemistry & Geophysics; Engineering; Remote Sensing; Imaging Science & Photographic Technology GA AR9MZ UT WOS:000343900600003 ER PT J AU Romeiser, R Graber, HC Caruso, MJ Jensen, RE Walker, DT Cox, AT AF Romeiser, Roland Graber, Hans C. Caruso, Michael J. Jensen, Robert E. Walker, David T. Cox, Andrew T. TI A New Approach to Ocean Wave Parameter Estimates From C-Band ScanSAR Images SO IEEE TRANSACTIONS ON GEOSCIENCE AND REMOTE SENSING LA English DT Article DE Image analysis; remote sensing; synthetic aperture radar (SAR); waves; wind ID SYNTHETIC-APERTURE RADAR; BACKSCATTERING CROSS-SECTION; A SATELLITE SCATTEROMETER; COMPOSITE SURFACE MODEL; SAR IMAGERY; WIND VECTOR; SPECTRUM; POLARIZATION; INVERSION; PERFORMANCE AB Because of their large swath widths of about 400-500 km, the ScanSAR modes of RADARSAT-1 and -2 and of the Advanced SAR (ASAR) system on Envisat have been the preferred modes of operation for hurricane and typhoon observations and similar applications. While C-band ScanSAR images have been demonstrated to be well suitable for wind retrievals, ocean wave retrievals are a more challenging problem: Because of the limited spatial resolution of 100 m (RADARSAT) / 150 m (Envisat), only long waves can get imaged directly, and many images of tropical storm scenarios do not exhibit clear signatures of any waves in large areas. The interpretation of wave patterns that exist in an image is difficult because of the imaging mechanism's nonlinearities. We think we have found a promising new technique for wave parameter retrievals from C-band ScanSAR images, which determines peak wavelengths and directions from image spectra where possible but uses an empirically determined relation to estimate significant wave heights (SWHs) from local mean image intensities, which is similar to the method used for wind retrievals. This way, it is possible to obtain SWH estimates for the entire image and to account for the contributions of subresolution-scale waves. We explain how the algorithm works and how the empirical SWH model function has been determined from a set of hurricane images from RADARSAT-1 and reference wave spectra from a numerical wave model. The first independent test with a set of RADARSAT-2 and Envisat images from the 2010 Impact of Typhoons on the Ocean in the Pacific (ITOP) experiment reveals a few weaknesses but essentially confirms the feasibility of the concept. C1 [Romeiser, Roland] Univ Miami, Rosenstiel Sch Marine & Atmospher Sci, Dept Ocean Sci, Miami, FL 33149 USA. [Graber, Hans C.] Univ Miami, Dept Ocean Sci, Miami, FL 33177 USA. [Graber, Hans C.; Caruso, Michael J.] Univ Miami, Rosenstiel Sch Marine & Atmospher Sci, Ctr Southeastern Trop Adv Remote Sensing, Miami, FL 33177 USA. [Jensen, Robert E.] US Army Corps Engineers, Coastal & Hydraul Lab, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. [Walker, David T.] SRI Int, Ann Arbor, MI 48105 USA. [Cox, Andrew T.] Oceanweather Inc, Cos Cob, CT 06807 USA. RP Romeiser, R (reprint author), Univ Miami, Rosenstiel Sch Marine & Atmospher Sci, Dept Ocean Sci, 4600 Rickenbacker Causeway, Miami, FL 33149 USA. EM rromeiser@rsmas.miami.edu; hgraber@rsmas.miami.edu; mcaruso@rsmas.miami.edu; Robert.E.Jensen@erdc.dren.mil; david.walker@sri.com; andrewc@oceanweather.com FU U.S. Office of Naval Research (ONR) [N00014-08-1-0581]; ONR [N00014-09-C-0530] FX This work was supported by the U.S. Office of Naval Research (ONR) under Grant N00014-08-1-0581. The work of D. T. Walker was supported by the ONR under Grant N00014-09-C-0530. NR 55 TC 4 Z9 4 U1 2 U2 30 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0196-2892 EI 1558-0644 J9 IEEE T GEOSCI REMOTE JI IEEE Trans. Geosci. Remote Sensing PD MAR PY 2015 VL 53 IS 3 BP 1320 EP 1345 DI 10.1109/TGRS.2014.2337663 PG 26 WC Geochemistry & Geophysics; Engineering, Electrical & Electronic; Remote Sensing; Imaging Science & Photographic Technology SC Geochemistry & Geophysics; Engineering; Remote Sensing; Imaging Science & Photographic Technology GA AR9MZ UT WOS:000343900600016 ER PT J AU Barnes, TA Kaminski, JW Borodin, O Miller, TF AF Barnes, Taylor A. Kaminski, Jakub W. Borodin, Oleg Miller, Thomas F., III TI Ab lnitio Characterization of the Electrochemical Stability and Solvation Properties of Condensed-Phase Ethylene Carbonate and Dimethyl Carbonate Mixtures SO JOURNAL OF PHYSICAL CHEMISTRY C LA English DT Article ID DENSITY-FUNCTIONAL-THEORY; LITHIUM-ION BATTERIES; ORGANIC ELECTROLYTE-SOLUTIONS; INITIO MOLECULAR-DYNAMICS; TRANSFER EXCITED-STATES; MANY-BODY EXPANSION; PROPYLENE CARBONATE; OXIDATION POTENTIALS; NONAQUEOUS ELECTROLYTES; QUANTUM-CHEMISTRY AB A central challenge in the refinement of lithium-ion batteries is to control cathode-induced oxidative decomposition of electrolyte solvents, such as ethylene carbonate (EC) and dimethyl carbonate (DMC). We study the oxidation potentials of neat EC, neat DMC, and 1:1 mixtures of EC and DMC using the newly developed projection-based embedding method, which we demonstrate to be capable of correcting qualitative inaccuracies in the electronic densities and ionization energies obtained from conventional Kohn-Sham density functional theory (DFT) methods. Our wave function-in-DFT embedding approach enables accurate calculation of the vertical ionization energy (IE) of individual molecules at the CCSD(T) level of theory while explicitly accounting for the solvent using a combination of DFT and molecular mechanics interactions. We find that the ensemble-averaged distributions of vertical IEs are consistent with a linear response interpretation of the statistics of the solvent configurations, enabling determination of both the intrinsic oxidation potential of the solvents and the corresponding solvent reorganization energies. Interestingly, we reveal that large contributions to the solvation properties of DMC originate from quadrupolar interactions, resulting in a much larger solvent reorganization energy than that predicted using simple dielectric continuum models. Demonstration that the solvation properties of EC and DMC are governed by fundamentally different intermolecular interactions provides insight into key aspects of lithium-ion batteries, with relevance to electrolyte decomposition processes, solidelectrolyte interphase formation, and the local solvation environment of lithium cations. C1 [Barnes, Taylor A.; Miller, Thomas F., III] CALTECH, Div Chem & Chem Engn, Pasadena, CA 91125 USA. [Kaminski, Jakub W.] Univ Calif Los Angeles, Dept Math, Los Angeles, CA 90095 USA. [Borodin, Oleg] US Army Res Lab, Electrochem Branch, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA. RP Miller, TF (reprint author), CALTECH, Div Chem & Chem Engn, Pasadena, CA 91125 USA. EM tfm@caltech.edu RI Borodin, Oleg/B-6855-2012 OI Borodin, Oleg/0000-0002-9428-5291 FU Office of Naval Research (ONR) [N00014-10-1-0884]; U.S. Army Research Laboratory; U.S. Army Research Office (USARO) [W911NF-10-1-0202] FX This work is supported by the Office of Naval Research (ONR) under Grant No. N00014-10-1-0884 and by the U.S. Army Research Laboratory and the U.S. Army Research Office (USARO) under Grant No. W911NF-10-1-0202. Computing resources were provided by the National Energy Research Scientific Computing Center (NERSC) (DE-AC02-05CH11231). NR 138 TC 19 Z9 19 U1 3 U2 51 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1932-7447 J9 J PHYS CHEM C JI J. Phys. Chem. C PD FEB 26 PY 2015 VL 119 IS 8 BP 3865 EP 3880 DI 10.1021/jp510882g PG 16 WC Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary SC Chemistry; Science & Technology - Other Topics; Materials Science GA CC4NE UT WOS:000350329300001 ER PT J AU Ayithan, N Bradfute, SB Anthony, SM Stuthman, KS Bavari, S Bray, M Ozato, K AF Ayithan, Natarajan Bradfute, Steven B. Anthony, Scott M. Stuthman, Kelly S. Bavari, Sina Bray, Mike Ozato, Keiko TI Virus-Like Particles Activate Type I Interferon Pathways to Facilitate Post-Exposure Protection against Ebola Virus Infection SO PLOS ONE LA English DT Article ID NF-KAPPA-B; DENDRITIC CELLS REQUIRES; TOLL-LIKE RECEPTOR; FILOVIRUS INFECTION; REGULATORY FACTOR-8; HEMORRHAGIC-FEVER; INFLAMMASOME ACTIVATION; CYTOKINE EXPRESSION; NEGATIVE REGULATION; IMMUNE-RESPONSES AB Ebola virus (EBOV) causes a severe hemorrhagic disease with high fatality. Virus-like particles (VLPs) are a promising vaccine candidate against EBOV. We recently showed that VLPs protect mice from lethal EBOV infection when given before or after viral infection. To elucidate pathways through which VLPs confer post-exposure protection, we investigated the role of type I interferon (IFN) signaling. We found that VLPs lead to accelerated induction of IFN stimulated genes (ISGs) in liver and spleen of wild type mice, but not in Ifnar(-/-)mice. Accordingly, EBOV infected Ifnar(-/-)mice, unlike wild type mice succumbed to death even after VLP treatment. The ISGs induced in wild type mice included anti-viral proteins and negative feedback factors known to restrict viral replication and excessive inflammatory responses. Importantly, proinflammatory cytokine/chemokine expression was much higher in WT mice without VLPs than mice treated with VLPs. In EBOV infected Ifnar(-/-)mice, however, uninhibited viral replication and elevated proinflammatory factor expression ensued, irrespective of VLP treatment, supporting the view that type I IFN signaling helps to limit viral replication and attenuate inflammatory responses. Further analyses showed that VLP protection requires the transcription factor, IRF8 known to amplify type I IFN signaling in dendritic cells and macrophages, the probable sites of initial EBOV infection. Together, this study indicates that VLPs afford post-exposure protection by promoting expeditious initiation of type I IFN signaling in the host. C1 [Ayithan, Natarajan; Ozato, Keiko] NICHHD, Program Genom Differentiat, NIH, Bethesda, MD 20892 USA. [Bradfute, Steven B.; Anthony, Scott M.; Stuthman, Kelly S.; Bavari, Sina] US Army, Med Inst Infect Dis, Ft Detrick, MD USA. [Bray, Mike] NIAID, Integrated Res Facil, NIH, Ft Detrick, MD USA. RP Ozato, K (reprint author), NICHHD, Program Genom Differentiat, NIH, Bethesda, MD 20892 USA. EM ozatok@nih.gov FU Intramural Program of NICHD; Trans-NIH FDA intramural Bio-defense Program, NIH FX This work was supported by the Intramural Program of NICHD and the Trans-NIH FDA intramural Bio-defense Program, NIH. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 58 TC 6 Z9 6 U1 2 U2 13 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD FEB 26 PY 2015 VL 10 IS 2 AR UNSP e0118345 DI 10.1371/journal.pone.0118345 PG 17 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA CC2ZH UT WOS:000350213200048 PM 25719445 ER PT J AU Huang, YM Rueda, LM AF Huang, Yiau-Min Rueda, Leopoldo M. TI Pictorial Keys to the Species of the Subgenera Albuginosus and Aedimorphus (Grjebinei and Apicoannulatus Groups) of the Genus Aedes Meigen in the Afrotropical Region (Diptera: Culicidae) SO ZOOTAXA LA English DT Article DE Culicidae; mosquitoes; identification key; Africa ID ALLIED TAXA DIPTERA; LIFE STAGES; MORPHOLOGICAL DATA; AEDINI DIPTERA; CLASSIFICATION; PHYLOGENY; OCHLEROTATUS AB Nine species of the subgenus Albuginosus, one species of the subgenus Aedimorphus Grjebinei Group and two species of the subgenus Aedimorphus Apicoannulatus Group of the genus Aedes Meigen in the Afrotropical Region are treated in three pictorial keys based on diagnostic morphological features. C1 [Huang, Yiau-Min] Smithsonian Inst, Dept Entomol, Washington, DC 20013 USA. [Rueda, Leopoldo M.] Walter Reed Army Inst Res, Walter Reed Biosystemat Unit, Entomol Branch, Silver Spring, MD 20910 USA. RP Huang, YM (reprint author), Smithsonian Inst, Dept Entomol, POB 37012,MSC C1109,MRC 534, Washington, DC 20013 USA. EM huangy@si.edu; ruedapol@si.edu NR 27 TC 1 Z9 1 U1 0 U2 2 PU MAGNOLIA PRESS PI AUCKLAND PA PO BOX 41383, AUCKLAND, ST LUKES 1030, NEW ZEALAND SN 1175-5326 EI 1175-5334 J9 ZOOTAXA JI Zootaxa PD FEB 26 PY 2015 VL 3925 IS 1 BP 25 EP 36 PG 12 WC Zoology SC Zoology GA CB9VN UT WOS:000349981700002 PM 25781728 ER PT J AU Shen, J Yin, W Kondoh, K Jones, TL Kecskes, LJ Yarmolenko, SN Wei, Q AF Shen, J. Yin, W. Kondoh, K. Jones, Tyrone L. Kecskes, L. J. Yarmolenko, S. N. Wei, Q. TI Mechanical behavior of a lanthanum-doped magnesium alloy at different strain rates SO MATERIALS SCIENCE AND ENGINEERING A-STRUCTURAL MATERIALS PROPERTIES MICROSTRUCTURE AND PROCESSING LA English DT Article DE Mg alloy; Mechanical properties; Adiabatic shear band (ASB); Strain rate sensitivity (SRS); High strain rate behavior ID SOLIDIFICATION POWDER-METALLURGY; SEVERE PLASTIC-DEFORMATION; SINGLE-CRYSTAL MAGNESIUM; HIGH-PRESSURE TORSION; ELEVATED-TEMPERATURES; ROOM-TEMPERATURE; MICROSTRUCTURAL EVOLUTION; MATRIX COMPOSITES; ULTRAFINE GRAIN; NONBASAL SLIP AB The mechanical behavior of a lanthanum doped Mg alloy, AZXE7111, (Mg-7Al-1Zn-1Ca-1La, all in wt%) extruded at different temperatures has been investigated under both quasi-static (strain rate similar to 1 x 10(-3) s(-1)) and dynamic (strain rate similar to 4 x 10(3) s(-1)) compressive loading. Comparison has been made against the experimental results of two conventional Mg alloys, AZ91E and WE43. It was observed via transmission electron microscopy (TEM) that the nanoscale intermetallic compounds of Al2Ca and Al11La3, have presumably formed during the hot extrusion process. These compounds are believed to contribute significantly to the strength by reducing the grain size and acting as dislocation barriers. Additionally, twinning has been considered as the main mechanism for the higher strain hardening rate at high strain rates than that at low strain rates. It has been found that the ultimate strength of the alloy is only similar to 10% higher at dynamic loading rate than at quasi-static loading rate. Localized micro-shear fracture was observed and adiabatic shear mode was suggested by further examination of dynamically loaded specimens. The shear localization is further discussed in detail and it is suggested that reduced strain hardening rate is responsible for shear localization and subsequent fracture at both low and high strain rates. (C) 2014 Elsevier B.V. All rights reserved. C1 [Shen, J.; Yin, W.; Wei, Q.] Univ N Carolina, Dept Mech Engn, Charlotte, NC 28223 USA. [Shen, J.] Northwestern Polytech Univ, Sch Aeronaut, Xian 710072, Peoples R China. [Kondoh, K.] Osaka Univ, Joining & Welding Res Inst, Osaka 5670047, Japan. [Jones, Tyrone L.; Kecskes, L. J.] US Army Res Lab, WMRD, Aberdeen Proving Ground, MD 21005 USA. [Yarmolenko, S. N.] N Carolina Agr & Tech State Univ, Dept Mech Engn, NSF ERC, Greensboro, NC 27411 USA. RP Wei, Q (reprint author), Univ N Carolina, Dept Mech Engn, Charlotte, NC 28223 USA. EM qwei@uncc.edu RI Wei, Qiuming/B-7579-2008; Shen, Jianghua/C-2586-2013; Yarmolenko, Sergey/E-6819-2017 OI Shen, Jianghua/0000-0003-1017-0698; FU U.S. Army Research Laboratory [W911QX-08-0073]; China Scholarship Council; National Natural Science Foundation of China [10932008]; 111 Project [B07050] FX This work is supported by U.S. Army Research Laboratory under Contract no. W911QX-08-0073. J. H. Shen would like to acknowledge the financial support from China Scholarship Council, National Natural Science Foundation of China (No. 10932008) and the 111 Project (No. B07050). NR 79 TC 2 Z9 2 U1 3 U2 28 PU ELSEVIER SCIENCE SA PI LAUSANNE PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND SN 0921-5093 EI 1873-4936 J9 MAT SCI ENG A-STRUCT JI Mater. Sci. Eng. A-Struct. Mater. Prop. Microstruct. Process. PD FEB 25 PY 2015 VL 626 BP 108 EP 121 DI 10.1016/j.msea.2014.12.061 PG 14 WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Science & Technology - Other Topics; Materials Science; Metallurgy & Metallurgical Engineering GA CC2QI UT WOS:000350189300015 ER PT J AU Farrington, HL Edwards, CE Guan, X Carr, MR Baerwaldt, K Lance, RF AF Farrington, Heather L. Edwards, Christine E. Guan, Xin Carr, Matthew R. Baerwaldt, Kelly Lance, Richard F. TI Mitochondrial Genome Sequencing and Development of Genetic Markers for the Detection of DNA of Invasive Bighead and Silver Carp (Hypophthalmichthys nobilis and H. molitrix) in Environmental Water Samples from the United States SO PLOS ONE LA English DT Article ID EDNA; INFORMATION; PERSISTENCE AB Invasive Asian bighead and silver carp (Hypophthalmichthys nobilis and H. molitrix) pose a substantial threat to North American aquatic ecosystems. Recently, environmental DNA (eDNA), genetic material shed by organisms into their environment that can be detected by non-invasive sampling strategies and genetic assays, has gained recognition as a tool for tracking the invasion front of these species toward the Great Lakes. The goal of this study was to develop new species-specific conventional PCR (cPCR) and quantitative (qPCR) markers for detection of these species in North American surface waters. We first generated complete mitochondrial genome sequences from 33 bighead and 29 silver carp individuals collected throughout their introduced range. These sequences were aligned with those from other common and closely related fish species from the Illinois River watershed to identify and design new species-specific markers for the detection of bighead and silver carp DNA in environmental water samples. We then tested these genetic markers in the laboratory for species-specificity and sensitivity. Newly developed markers performed well in field trials, did not have any false positive detections, and many markers had much higher detection rates and sensitivity compared to the markers currently used in eDNA surveillance programs. We also explored the use of multiple genetic markers to determine whether it would improve detection rates, results of which showed that using multiple highly sensitive markers should maximize detection rates in environmental samples. The new markers developed in this study greatly expand the number of species-specific genetic markers available to track the invasion front of bighead and silver carp and will improve the resolution of these assays. Additionally, the use of the qPCR markers developed in this study may reduce sample processing time and cost of eDNA monitoring for these species. C1 [Farrington, Heather L.; Edwards, Christine E.; Guan, Xin; Carr, Matthew R.; Lance, Richard F.] United States Army, Engn Res & Dev Ctr, Environm Lab, Vicksburg, MS 39183 USA. [Baerwaldt, Kelly] United States Army, Corps Engn, Rock Isl, IL USA. RP Lance, RF (reprint author), United States Army, Engn Res & Dev Ctr, Environm Lab, Vicksburg, MS 39183 USA. EM richard.f.lance@usace.army.mil OI Edwards, Christine/0000-0001-8837-4872 FU Asian Carp Regional Coordinating Committee FX Funding for this project was provided to KB and RFL by the Asian Carp Regional Coordinating Committee (http://asiancarp.us). The funder had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 34 TC 1 Z9 1 U1 9 U2 51 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD FEB 23 PY 2015 VL 10 IS 2 AR e0117803 DI 10.1371/journal.pone.0117803 PG 17 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA CC9BI UT WOS:000350662100119 PM 25706532 ER PT J AU Johnston, SC Briese, T Bell, TM Pratt, WD Shamblin, JD Esham, HL Donnelly, GC Johnson, JC Hensley, LE Lipkin, WI Honko, AN AF Johnston, Sara C. Briese, Thomas Bell, Todd M. Pratt, William D. Shamblin, Joshua D. Esham, Heather L. Donnelly, Ginger C. Johnson, Joshua C. Hensley, Lisa E. Lipkin, W. Ian Honko, Anna N. TI Detailed Analysis of the African Green Monkey Model of Nipah Virus Disease SO PLOS ONE LA English DT Article ID ENCEPHALITIS OUTBREAK; FLYING-FOXES; TRANSMISSION; HENIPAVIRUS; INFECTION; BANGLADESH; PATHOLOGY; MALAYSIA; HENDRA; BATS AB Henipaviruses are implicated in severe and frequently fatal pneumonia and encephalitis in humans. There are no approved vaccines or treatments available for human use, and testing of candidates requires the use of well-characterized animal models that mimic human disease. We performed a comprehensive and statistically-powered evaluation of the African green monkey model to define parameters critical to disease progression and the extent to which they correlate with human disease. African green monkeys were inoculated by the intratracheal route with 2.5x10(4) plaque forming units of the Malaysia strain of Nipah virus. Physiological data captured using telemetry implants and assessed in conjunction with clinical pathology were consistent with shock, and histopathology confirmed widespread tissue involvement associated with systemic vasculitis in animals that succumbed to acute disease. In addition, relapse encephalitis was identified in 100% of animals that survived beyond the acute disease phase. Our data suggest that disease progression in the African green monkey is comparable to the variable outcome of Nipah virus infection in humans. C1 [Johnston, Sara C.; Pratt, William D.; Shamblin, Joshua D.; Esham, Heather L.; Donnelly, Ginger C.; Johnson, Joshua C.; Hensley, Lisa E.; Lipkin, W. Ian; Honko, Anna N.] US Army, Med Res Inst Infect Dis, Div Virol, Ft Detrick, MD 21702 USA. [Briese, Thomas] Columbia Univ, Mailman Sch Publ Hlth, Ctr Infect & Immun, New York, NY USA. [Bell, Todd M.] US Army, Med Res Inst Infect Dis, Div Pathol, Ft Detrick, MD 21702 USA. RP Honko, AN (reprint author), Natl Inst Allergy & Infect Dis, Integrated Res Facil, 8200 Res Plaza, Ft Detrick, MD 21702 USA. EM anna.honko@nih.gov OI Johnson, Joshua/0000-0002-5677-3841; Honko, Anna/0000-0001-9165-148X FU Northeast Biodefense Center [AI57158]; USAMRIID [1882367] FX This work was supported by AI57158 (Northeast Biodefense Center) and performed under USAMRIID project number 1882367. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 30 TC 2 Z9 2 U1 0 U2 11 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD FEB 23 PY 2015 VL 10 IS 2 AR e0117817 DI 10.1371/journal.pone.0117817 PG 24 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA CC9BI UT WOS:000350662100120 PM 25706617 ER PT J AU Sawe, FK Obiero, E Yegon, P Langat, RC Aoko, A Tarus, J Kiptoo, I Langat, RK Maswai, J Bii, M Khamadi, S Shikuku, KP Close, N Sinei, S Shaffer, DN AF Sawe, Fredrick K. Obiero, Eunice Yegon, Peter Langat, Rither C. Aoko, Appolonia Tarus, Jemutai Kiptoo, Ignatius Langat, Raphael K. Maswai, Jonah Bii, Margaret Khamadi, Samoel Shikuku, Kibet P. Close, Nicole Sinei, Samuel Shaffer, Douglas N. TI Kericho CLinic-Based ART Diagnostic Evaluation (CLADE): Design, Accrual, and Baseline Characteristics of a Randomized Controlled Trial Conducted in Predominately Rural, District-Level, HIV Clinics of Kenya SO PLOS ONE LA English DT Article ID ANTIRETROVIRAL TREATMENT FAILURE; VIRAL LOAD; COLLABORATIVE ANALYSIS; VIROLOGICAL FAILURE; SOUTH-AFRICA; CELL COUNT; THERAPY; ROUTINE; COHORT; ADULTS AB Background Prospective clinical trial data regarding routine HIV-1 viral load (VL) monitoring of antiretroviral therapy (ART) in non-research clinics of Sub-Saharan Africa are needed for policy makers. Methods CLinic-based ART Diagnostic Evaluation (CLADE) is a randomized, controlled trial (RCT) evaluating feasibility, superiority, and cost-effectiveness of routine VL vs. standard of care (clinical and immunological) monitoring in adults initiating dual nucleoside reverse transcriptase inhibitor (NRTI)+non-NRTI ART. Participants were randomized (1:1) at 7 predominately rural, non-research, district-level clinics of western Kenya. Descriptive statistics present accrual patterns and baseline cohort characteristics. Results Over 15 months, 820 adults enrolled at 7 sites with 86-152 enrolled per site. Monthly site enrollment ranged from 2-92 participants. Full (100%) informed consent compliance was independently documented. Half (49.9%) had HIV diagnosed through voluntary counseling and testing. Study arms were similar: mostly females (57.6%) aged 37.6 (SD = 9.0) years with low CD4 (166 [SD = 106]) cells/m(3)). Notable proportions had WHO Stage III or IV disease (28.7%), BMI < 18.5 kg/m(2) (23.1%), and a history of tuberculosis (5.6%) or were receiving tuberculosis treatment (8.2%) at ART initiation. In the routine VL arm, 407/409 (99.5%) received baseline VL (234,577 SD = 151,055 copies/ml). All participants received lamivudine; 49.8% started zidovudine followed by 38.4% stavudine and 11.8% tenofovir; and, 64.4% received nevirapine as nNRTI (35.6% efavirenz). Conclusions A RCT can be enrolled successfully in rural, non-research, resource limited, district-level clinics in western Kenya. Many adults presenting for ART have advanced HIV/AIDS, emphasizing the importance of universal HIV testing and linkage-to-care campaigns. C1 [Sawe, Fredrick K.; Yegon, Peter; Langat, Rither C.; Aoko, Appolonia; Tarus, Jemutai; Kiptoo, Ignatius; Langat, Raphael K.; Maswai, Jonah; Bii, Margaret; Khamadi, Samoel; Shikuku, Kibet P.; Sinei, Samuel; Shaffer, Douglas N.] Kenya Govt Med Res Ctr, Walter Reed Project, Kericho, Kenya. [Sawe, Fredrick K.; Shaffer, Douglas N.] US Mil HIV Res Program, Walter Reed Army Inst Res, Silver Spring, MD USA. [Sawe, Fredrick K.] Henry M Jackson Fdn Adv Mil Med, Rockville, MD USA. [Obiero, Eunice] Kenya Minist Publ Hlth & Sanitat, Kericho Dist Hosp, Kericho, Kenya. [Yegon, Peter; Langat, Rither C.; Aoko, Appolonia; Tarus, Jemutai; Langat, Raphael K.; Maswai, Jonah; Bii, Margaret; Khamadi, Samoel; Sinei, Samuel] HJF Med Res Int Inc, Kericho, Kenya. [Close, Nicole] EmpiriStat, Mt Airy, MD USA. RP Sawe, FK (reprint author), Kenya Govt Med Res Ctr, Walter Reed Project, Kericho, Kenya. EM Fredrick.Sawe@usamru-k.org FU U.S. Office of the Global AIDS Coordinator [KE-07-0044]; Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. [W81XWH-07-2-0067]; U.S. Department of Defense (DOD) [W81XWH-07-2-0067, W81XWH-07-2-0065]; Kenya Medical Research Institute [W81XWH-07-2-0065] FX The Clinic-based ART Diagnostic Evaluation (CLADE) trial is sponsored by the U.S. Office of the Global AIDS Coordinator (#KE-07-0044). This work was also supported by a cooperative agreement (W81XWH-07-2-0067) between the Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., and the U.S. Department of Defense (DOD). Funding was also received through a cooperative agreement (W81XWH-07-2-0065) between the Kenya Medical Research Institute and the U.S. Department of Defense (DOD). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 39 TC 0 Z9 0 U1 0 U2 2 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD FEB 23 PY 2015 VL 10 IS 2 AR e0116299 DI 10.1371/journal.pone.0116299 PG 15 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA CC9BI UT WOS:000350662100030 PM 25706652 ER PT J AU Shurtleff, AC Whitehouse, CA Ward, MD Cazares, LH Bavari, S AF Shurtleff, Amy C. Whitehouse, Chris A. Ward, Michael D. Cazares, Lisa H. Bavari, Sina TI Pre-symptomatic diagnosis and treatment of filovirus diseases SO FRONTIERS IN MICROBIOLOGY LA English DT Review DE Ebola; Marburg; diagnostics; therapeutics; zoonosis ID EBOLA HEMORRHAGIC-FEVER; MEDIATED ISOTHERMAL AMPLIFICATION; STOMATITIS-VIRUS VECTORS; NONHUMAN-PRIMATES; MARBURG VIRUS; RHESUS MACAQUES; POSTEXPOSURE PROTECTION; CYNOMOLGUS MACAQUES; MORPHOLINO OLIGOMERS; FAVIPIRAVIR T-705 AB Filoviruses are virulent human pathogens which cause severe illness with high case fatality rates and for which there are no available FDA-approved vaccines or therapeutics. Diagnostic tools including antibody- and molecular-based assays, mass spectrometry, and next-generation sequencing are continually under development. Assays using the polymerase chain reaction (PCR) have become the mainstay for the detection of filoviruses in outbreak settings. In many cases, real-time reverse transcriptase-PCR allows for the detection of filoviruses to be carried out with minimal manipulation and equipment and can provide results in less than 2 h. In cases of novel, highly diverse filoviruses, random-primed pyrosequencing approaches have proved useful. Ideally, diagnostic tests would allow for diagnosis of filovirus infection as early as possible after infection, either before symptoms begin, in the event of a known exposure or epidemiologic outbreak, or post-symptomatically. If tests could provide an early definitive diagnosis, then this information may be used to inform the choice of possible therapeutics. Several exciting new candidate therapeutics have been described recently; molecules that have therapeutic activity when administered to animal models of infection several days post-exposure, once signs of disease have begun. The latest data for candidate nucleoside analogs, small interfering RNA (siRNA) molecules, phosphorodiamidate (PMO) molecules, as well as antibody and blood-product therapeutics and therapeutic vaccines are discussed. For filovirus researchers and government agencies interested in making treatments available for a nation's defense as well as its general public, having the right diagnostic tools to identify filovirus infections, as well as a panel of available therapeutics for treatment when needed, is a high priority. Additional research in both areas is required for ultimate success, but significant progress is being made to reach these goals. C1 [Shurtleff, Amy C.; Whitehouse, Chris A.; Ward, Michael D.; Cazares, Lisa H.; Bavari, Sina] US Army, Med Res Inst Infect Dis, Mol & Translat Sci Div, Ft Detrick, MD 21702 USA. RP Bavari, S (reprint author), US Army, Med Res Inst Infect Dis, Mol & Translat Sci Div, 1425 Porter St, Ft Detrick, MD 21702 USA. EM sina.bavari.civ@mail.mil FU US Defense Threat Reduction Agency; Medical Countermeasures Systems FX Opinions, interpretations, conclusions and recommendations are those of the authors and are not necessarily endorsed by the US Army. The authors would like to acknowledge funding from the US Defense Threat Reduction Agency and Medical Countermeasures Systems. We also thank Trevor Johnston for contributing the illustration of the man wearing a biocontainment suit used in Figure 1. NR 114 TC 5 Z9 5 U1 1 U2 20 PU FRONTIERS MEDIA SA PI LAUSANNE PA PO BOX 110, EPFL INNOVATION PARK, BUILDING I, LAUSANNE, 1015, SWITZERLAND SN 1664-302X J9 FRONT MICROBIOL JI Front. Microbiol. PD FEB 20 PY 2015 VL 6 AR 108 DI 10.3389/fmicb.2015.00108 PG 13 WC Microbiology SC Microbiology GA CC4GT UT WOS:000350311100001 PM 25750638 ER PT J AU Mc Aninch, IM Palmese, GR Lenhart, JL La Scala, JJ AF Mc Aninch, Ian M. Palmese, Giuseppe R. Lenhart, Joseph L. La Scala, John J. TI Epoxy-Amine Networks with Varying Epoxy Polydispersity SO JOURNAL OF APPLIED POLYMER SCIENCE LA English DT Article DE glass transition; mechanical properties; properties and characterization; resins; thermosets ID THERMAL-EXPANSION; FRACTURE-TOUGHNESS; RESINS; BEHAVIOR; VISCOELASTICITY; COEFFICIENT; MECHANISMS; WEIGHTS; BLENDS AB Solid, high molecular weight DGEBA-based epoxies were blended with high purity liquid DGEBA to create several resins with equivalent epoxy equivalent weights, but with polydispersity indices (PDIs) ranging from 3 to over 10. The resins were cured with a stoichiometric amount of polyetheramine and compared to a nonblended epoxy with PDI of 1.8. Modulus, glass transition temperatures, and molecular weight between cross-links were measured using dynamic mechanical analysis. Coefficients of thermal expansion (CTE) were measured and used to extend room temperature density measurements as a function of temperature. Fracture properties were also measured. Overall, the increased polydispersity has almost negligible effect, with the main difference occurring in the slope of the glassy CTE, with more polydisperse epoxies having a slower increase in CTE. In comparison to previous work where bimodal amines were blended with DGEBA, we conclude that epoxy resins are far more sensitive to distributions in the flexible portion, rather than the more rigid one. (c) 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015, 132, 41503. C1 [Mc Aninch, Ian M.; La Scala, John J.] US Army, Res Lab, Attn RDRL WMM C, Aberdeen Proving Ground, MD 21005 USA. [Mc Aninch, Ian M.; Palmese, Giuseppe R.] Drexel Univ, Dept Chem & Biol Engn, Philadelphia, PA 19104 USA. [Lenhart, Joseph L.] US Army, Res Lab, Attn RDRL WMM G, Aberdeen Proving Ground, MD 21005 USA. RP La Scala, JJ (reprint author), US Army, Res Lab, Attn RDRL WMM C, Aberdeen Proving Ground, MD 21005 USA. EM john.j.lascala.civ@mail.mil OI McAninch, Ian/0000-0002-9190-2936 FU US Army Research Laboratory under the Army Materials Center of Excellence Program [W911NF-06-2-0013]; Oak Ridge Institute for Science and Education FX This research was supported in part by an appointment to the Student Research Participation Program at the U.S. Army Research Laboratory administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the U.S. Department of Energy and USARL. Additional support was provided by the US Army Research Laboratory under the Army Materials Center of Excellence Program, Contract W911NF-06-2-0013. NR 30 TC 2 Z9 2 U1 1 U2 48 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0021-8995 EI 1097-4628 J9 J APPL POLYM SCI JI J. Appl. Polym. Sci. PD FEB 20 PY 2015 VL 132 IS 8 AR 41503 DI 10.1002/app.41503 PG 9 WC Polymer Science SC Polymer Science GA AU3LK UT WOS:000345514500017 ER PT J AU Li, Z Borodin, O Smith, GD Bedrov, D AF Li, Zhe Borodin, Oleg Smith, Grant D. Bedrov, Dmitry TI Effect of Organic Solvents on Li+ Ion Solvation and Transport in Ionic Liquid Electrolytes: A Molecular Dynamics Simulation Study SO JOURNAL OF PHYSICAL CHEMISTRY B LA English DT Article ID N-PROPYLPYRROLIDINIUM BIS(TRIFLUOROMETHANESULFONYL)IMIDE; LITHIUM ION; ETHYLENE CARBONATE; SALT MIXTURES; RAMAN; ACETONITRILE; ASSOCIATION; BATTERIES; CONDUCTIVITY; COORDINATION AB Molecular dynamics simulations of N-methyl-N-propylpyrrolidinium (pyr(13)) bis(trifluoromethanesulfonyl)imide (Ntf(2)) ionic liquid [pyr(13)][Ntf(2)] doped with [Li][Ntf(2)] salt and mixed with acetonitrile (AN) and ethylene carbonate (EC) organic solvents were conducted using polarizable force field. Structural and transport properties of ionic liquid electrolytes (ILEs) with 20 and 40 mol % of organic solvents have been investigated and compared to properties of neat ILEs. Addition of AN and EC solvents to ILEs resulted in the partial displacement of the Ntf2 anions from the Li+ first coordination shell by EC and AN and shifting the LiNtf(2) coordination from bidentate to monodentate. The presence of organic solvents in ILE has increased the ion mobility, with the largest effect observed for the Li+ cation. The Li+ conductivity has doubled with addition of 40 mol % of AN. The Li(+)NNtf(2) residence times were dramatically reduced with addition of solvents, indicating an increasing contribution from structural diffusion of the Li+ cations. C1 [Li, Zhe; Bedrov, Dmitry] Univ Utah, Dept Mat Sci & Engn, Salt Lake City, UT 84112 USA. [Borodin, Oleg] Army Res Lab, Electrochem Branch, Adelphi, MD 20783 USA. [Smith, Grant D.; Bedrov, Dmitry] Wasatch Mol Inc, Salt Lake City, UT 84103 USA. RP Bedrov, D (reprint author), Univ Utah, Dept Mat Sci & Engn, 122 South Cent Campus Dr,Room 304, Salt Lake City, UT 84112 USA. EM d.bedrov@utah.edu RI li, zhe/C-9603-2014; Borodin, Oleg/B-6855-2012 OI Borodin, Oleg/0000-0002-9428-5291 FU U.S. Department of Energy [DE-AC02-05CH11231 on PO No. 6838611]; Army Research Laboratory [W911NF-12-2-0023] FX The authors are grateful for financial support of this work by the U.S. Department of Energy through Grant DE-AC02-05CH11231 on PO No. 6838611 to University of Utah and by the Army Research Laboratory under Cooperative Agreement Number W911NF-12-2-0023. The views and conclusions contained in this document are those of the authors and should not be interpreted as representing the official policies, either expressed or implied, of the Army Research Laboratory or the U.S. Government. NR 52 TC 10 Z9 10 U1 7 U2 75 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1520-6106 J9 J PHYS CHEM B JI J. Phys. Chem. B PD FEB 19 PY 2015 VL 119 IS 7 BP 3085 EP 3096 DI 10.1021/jp510644k PG 12 WC Chemistry, Physical SC Chemistry GA CB9HJ UT WOS:000349942300031 PM 25592777 ER PT J AU Waagen, A Verma, G Chan, K Swami, A D'Souza, R AF Waagen, Alex Verma, Gunjan Chan, Kevin Swami, Ananthram D'Souza, Raissa TI Effect of zealotry in high-dimensional opinion dynamics models SO PHYSICAL REVIEW E LA English DT Article ID IMPACT AB Most of the work on opinion dynamics models focuses on the case of two or three opinion types. We consider the case of an arbitrary number of opinions in the mean field case of the naming game model in which it is assumed the population is infinite and all individuals are neighbors. A particular challenge of the naming game model is that the number of variables, which corresponds to the number of possible sets of opinions, grows exponentially with the number of possible opinions. We present a method for generating mean field dynamical equations for the general case of k opinions. We calculate the steady states in two important special cases in arbitrarily high dimension: the case in which there exist zealots of only one type, and the case in which there are an equal number of zealots for each opinion. We show that in these special cases a phase transition occurs at critical values pc of the parameter p describing the fraction of zealots. In the former case, the critical value determines the threshold value beyond which it is not possible for the opinion with no zealots to be held by more nodes than the opinion with zealots, and this point remains fixed regardless of dimension. In the latter case, the critical point pc is the threshold value beyond which a stalemate between all k opinions is guaranteed, and we show that it decays precisely as a lognormal curve in k. C1 [Waagen, Alex; D'Souza, Raissa] Univ Calif Davis, Davis, CA 95616 USA. [Verma, Gunjan; Chan, Kevin; Swami, Ananthram] US Army Res Lab, Adelphi, MD 20783 USA. [D'Souza, Raissa] Santa Fe Inst, Santa Fe, NM 87501 USA. RP Waagen, A (reprint author), Univ Calif Davis, Davis, CA 95616 USA. FU U.S. Army Research Laboratory [W911NF-09-2-0053]; U.S. Army Research Office under MURI [W911NF-13-1-0340] FX We gratefully acknowledge support from the U.S. Army Research Laboratory under Cooperative Agreement No. W911NF-09-2-0053 (Network Science CTA) and from the U.S. Army Research Office under MURI Award No. W911NF-13-1-0340. The views and conclusions contained in this document are those of the authors and should not be interpreted as representing the official policies, either expressed or implied, of the Army Research Laboratory or the U.S. Government. NR 26 TC 12 Z9 12 U1 3 U2 14 PU AMER PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 1539-3755 EI 1550-2376 J9 PHYS REV E JI Phys. Rev. E PD FEB 18 PY 2015 VL 91 IS 2 AR 022811 DI 10.1103/PhysRevE.91.022811 PG 10 WC Physics, Fluids & Plasmas; Physics, Mathematical SC Physics GA CC3TV UT WOS:000350273900008 PM 25768556 ER PT J AU Duy, J Koehler, JW Honko, AN Minogue, TD AF Duy, Janice Koehler, Jeffrey W. Honko, Anna N. Minogue, Timothy D. TI Optimized microRNA purification from TRIzol-treated plasma SO BMC GENOMICS LA English DT Article DE microRNA; TRIzol; Ebola virus; RNA extraction; Plasma; Biomarker; RT-PCR; Nonhuman primate ID CIRCULATING MICRORNAS; BLOOD; EXTRACTION; EXPRESSION; MIRNAS; QUANTIFICATION; PCR; RNA; CHALLENGES; BIOMARKERS AB Background: MicroRNAs (miRNAs) represent new and potentially informative diagnostic targets for disease detection and prognosis. However, little work exists documenting the effect of TRIzol, a common viral inactivation and nucleic acid extraction reagent, on miRNA purification. Here, we developed an optimized protocol for miRNA extraction from plasma samples by evaluating five different RNA extraction kits, TRIzol phase separation, purification additives, and initial plasma sample volume. This method was then used for downstream profiling of plasma miRNAs found in archived samples from one nonhuman primate (NHP) experimentally challenged with Ebola virus by the aerosol route. Results: Comparison of real-time RT-PCR results for spiked-in and endogenous miRNA sequences determined extraction efficiencies from five different RNA purification kits. These experiments showed that 50 mu L plasma processed using the QIAGEN miRNeasy Mini Kit with 5 mu g of glycogen as a co-precipitant yielded the highest recovery of endogenous miRNAs. Using this optimized protocol, miRNAs from archived plasma samples of one rhesus macaque challenged with aerosolized Ebola virus was profiled using a targeted real-time PCR array. A total of 519 of the 752 unique miRNAs assayed were present in the plasma samples at day 0 and day 7 (time of death) post-exposure. Statistical analyses revealed 25 sequences significantly up- or down-regulated between day 0 and day 7 post infection, validating the utility of the extraction method for plasma miRNA profiling. Conclusions: This study contributes to the knowledgebase of circulating miRNA extraction methods and expands on the potential applications of cell-free miRNA profiling for diagnostics and pathogenesis studies. Specifically, we optimized an extraction protocol for miRNAs from TRIzol-inactivated plasma samples that can be used for highly pathogenic viruses. C1 [Duy, Janice; Koehler, Jeffrey W.; Minogue, Timothy D.] US Army, Diagnost Syst Div, Res Inst Infect Dis, Frederick, MD 21701 USA. [Honko, Anna N.] NIAID, Integrated Res Facil, NIH, Frederick, MD 21701 USA. [Honko, Anna N.] US Army, Virol Div, Med Inst Infect Dis, Frederick, MD 21701 USA. RP Minogue, TD (reprint author), US Army, Diagnost Syst Div, Res Inst Infect Dis, 1425 Porter St, Frederick, MD 21701 USA. EM timothy.d.minogue.civ@mail.mil OI Honko, Anna/0000-0001-9165-148X; Koehler, Jeffrey/0000-0003-3225-6599 FU Defense Threat Reduction Agency (DTRA) under USAMRIID project [1442078] FX The authors would like to thank USAMRIID Veterinary Medicine Corps for blood samples from healthy nonhuman primates, and Dr. Samuel Dickson for his help with statistical analyses. Research was conducted under an IACUC approved protocol in compliance with the Animal Welfare Act, PHS Policy, and other Federal statutes and regulations relating to animals and experiments involving animals. The facility where this research was conducted is accredited by the Association for Assessment and Accreditation of Laboratory Animal Care, International and adheres to principles stated in the Guide for the Care and Use of Laboratory Animals, National Research Council, 2011. This research was funded by the Defense Threat Reduction Agency (DTRA) under USAMRIID project number 1442078. The opinions, interpretations, conclusions, and recommendations contained herein are those of the authors and are not necessarily endorsed by the U.S. Army. NR 44 TC 4 Z9 4 U1 4 U2 16 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1471-2164 J9 BMC GENOMICS JI BMC Genomics PD FEB 18 PY 2015 VL 16 AR 95 DI 10.1186/s12864-015-1299-5 PG 9 WC Biotechnology & Applied Microbiology; Genetics & Heredity SC Biotechnology & Applied Microbiology; Genetics & Heredity GA CC2GP UT WOS:000350163500002 PM 25765146 ER PT J AU Tannenbaum, LV Oosterbroek, LN Caro-Riano, H AF Tannenbaum, Lawrence V. Oosterbroek, Leila N. Caro-Riano, Harling TI Compromised Chemical Toxicity in Year-Weathered Soils: Implications for Compromised Toxicity Factors SO HUMAN AND ECOLOGICAL RISK ASSESSMENT LA English DT Article DE 2, 4-dinitrotoluene; risk; toxicity; soil; toxicity factor; lead; weathering ID BIOAVAILABILITY; SEQUESTRATION; DDT; PHENANTHRENE; DIELDRIN; RISK; RDX; HMX AB With contaminated terrestrial sites always being multiple decades old before they first submit to health risk assessments for humans and ecological receptors, there is great opportunity for soils to elicit markedly lesser chemical toxicity than would be expected. Soil aging and weathering foster various physico-chemical processes that reduce the toxic potency or bioavailability of sequestered chemicals. Because only brand new and unadulterated chemicals with seemingly maximum potencies are used in animal dosing that supports toxicity factor derivation, measured chemical concentrations in soil can be misleading, producing exaggerated risk and hazard outcomes. We sought to determine the extent to which toxicity reduction occurs in experimentally amended soils, working with large soil volumes exposed to the unimpeded ambient condition for a calendar year. A broad toxicity testing matrix for two chemicals (i.e., multiple test species, endpoints, effect level concentrations, and soil types), found species' responses in contaminated soils to be indistinguishable from those in control soil 80% and 98% of the time for the inorganic and organic compounds used, respectively; a case in point was lead with a soil concentration of 11,000mg/kg. The results suggest that incorporating a toxicity reduction term is an indispensable task when deriving toxicity factors. C1 [Tannenbaum, Lawrence V.] Publ Hlth Command, Army Inst Publ Hlth, Aberdeen Proving Ground, MD USA. [Oosterbroek, Leila N.; Caro-Riano, Harling] HydroQual Labs Ltd, Calgary, AB, Canada. RP Tannenbaum, LV (reprint author), US Army Publ Hlth Command, MCHB IP REH, Bldg 1675, Apg Ea, MD 21010 USA. EM lawrence.v.tannenbaum.civ@mail.mil FU U.S. Army Environmental Command FX The authors thank the U.S. Army Environmental Command (Mr. Jim Daniel) for funding this study. NR 24 TC 0 Z9 0 U1 1 U2 2 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA SN 1080-7039 EI 1549-7860 J9 HUM ECOL RISK ASSESS JI Hum. Ecol. Risk Assess. PD FEB 17 PY 2015 VL 21 IS 2 BP 375 EP 396 DI 10.1080/10807039.2014.916550 PG 22 WC Biodiversity Conservation; Environmental Sciences SC Biodiversity & Conservation; Environmental Sciences & Ecology GA AQ1DF UT WOS:000342520900006 ER PT J AU Lee, BG Dupuis, N Pepeljugoski, P Schares, L Budd, R Bickford, JR Schow, CL AF Lee, Benjamin G. Dupuis, Nicolas Pepeljugoski, Petar Schares, Laurent Budd, Russell Bickford, Justin R. Schow, Clint L. TI Silicon Photonic Switch Fabrics in Computer Communications Systems SO JOURNAL OF LIGHTWAVE TECHNOLOGY LA English DT Article DE Multiprocessor interconnection networks; optical switch; silicon photonics ID NETWORKS-ON-CHIP; SEMICONDUCTOR OPTICAL AMPLIFIERS; ELECTROOPTIC SWITCH; ULTRA-COMPACT; OUTPUT-POWER; INTERCONNECTION; INTEGRATION; ROUTER; LASER; TRANSMISSION AB We discuss silicon photonic switch fabric designs that target data-intensive computing networks, reviewing recent results, and projecting future performance goals. We analyze the achievements of demonstrated hardware in terms of switching time, footprint, crosstalk, and power consumption, concluding that the most crucial metric to improve upon is net loss. We propose integrating semiconductor optical amplifiers into the switch fabric using either flip-chip or wafer-bonding technology, and investigate its potential merits alongside several challenges in implementation. Furthermore, we explore the dominant causes of crosstalk, and discuss manners for reducing it. We perform switch simulations that project a 7-dB reduction in crosstalk, when using a push-pull, rather than a single-ended phase shifter drive scheme. We also evaluate crosstalk effects on transmission performance using a full-link model that incorporates multiple crosstalk-accumulating photonic switch hops. The study demonstrates the degree to which crosstalk may degrade signal integrity after just a few occurrences. Finally, a comparison of four topologies highlights tradeoffs in physical-layer design and scheduling complexity, illustrating the scales that may be accomplished with the simplest topologies, and the device improvements required to achieve the more robust architectures. C1 [Lee, Benjamin G.; Dupuis, Nicolas; Pepeljugoski, Petar; Schares, Laurent; Budd, Russell; Schow, Clint L.] IBM Corp, Thomas J Watson Res Ctr, Yorktown Hts, NY 10598 USA. [Bickford, Justin R.] US Army Res Lab, Adelphi Lab Ctr, Adelphi, MD 20783 USA. RP Lee, BG (reprint author), IBM Corp, Thomas J Watson Res Ctr, Yorktown Hts, NY 10598 USA. EM bglee@us.ibm.com; ndupuis@us.ibm.com; petarp@us.ibm.com; schares@us.ibm.com; rbudd@us.ibm.com; justin.r.bickford.civ@mail.mil; cschow@us.ibm.com FU Defense Advanced Research Projects Agency; Army Research Laboratory [W911NF-12-2-0051] FX This work was supported by the Defense Advanced Research Projects Agency and the Army Research Laboratory under Contract W911NF-12-2-0051. The views, opinions, and/or findings contained in this article are those of the authors and should not be interpreted as representing the official views or policies, either expressed or implied, of DARPA or the Department of Defense. Approved for public release, distribution unlimited. NR 52 TC 17 Z9 17 U1 1 U2 16 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0733-8724 EI 1558-2213 J9 J LIGHTWAVE TECHNOL JI J. Lightwave Technol. PD FEB 15 PY 2015 VL 33 IS 4 SI SI BP 768 EP 777 DI 10.1109/JLT.2014.2371616 PG 10 WC Engineering, Electrical & Electronic; Optics; Telecommunications SC Engineering; Optics; Telecommunications GA CC3BC UT WOS:000350218100007 ER PT J AU Earwood, JS Thompson, TD AF Earwood, John Scott Thompson, Timothy Daniel TI Hemoptysis: Evaluation and Management SO AMERICAN FAMILY PHYSICIAN LA English DT Article ID MASSIVE HEMOPTYSIS; TUBERCULOSIS; PREDICTION; DIAGNOSIS AB Hemoptysis is the expectoration of blood from the lung parenchyma or airways. The initial step in the evaluation is determining the origin of bleeding. Pseudohemoptysis is identified through the history and physical examination. In adults, acute respiratory tract infections (e.g., bronchitis, pneumonia), bronchiectasis, asthma, chronic obstructive pulmonary disease, and malignancy are the most common causes. Tuberculosis is a major cause of hemoptysis in endemic regions of the world. Although tuberculosis rates are low in the United States, they are increased in persons who are homeless or who were born in other countries; consideration for testing should be made on an individual basis. Hemodynamic instability, abnormal gas exchange, cardiopulmonary comorbidities, and lesions at high risk of massive bleeding warrant inpatient evaluation. Chest radiography is recommended as the initial diagnostic test for hemodynamically stable patients with hemoptysis. Further evaluation with computed tomography with or without bronchoscopy is recommended in patients with massive hemoptysis, those with abnormal radiographic findings, and those with risk factors for malignancy despite normal radiographic findings. Copyright (C) 2015 American Academy of Family Physicians. C1 [Earwood, John Scott] Dwight D Eisenhower Army Med Ctr, Family Med Residency Program, Ft Gordon, GA 30905 USA. [Earwood, John Scott] Dwight D Eisenhower Army Med Ctr, Family Med Residency Program, Dept Family Med, Ft Gordon, GA 30905 USA. [Thompson, Timothy Daniel] Mendoza Clin, Ft Bliss, TX USA. RP Earwood, JS (reprint author), Dwight D Eisenhower Army Med Ctr, 300 Hosp Dr, Ft Gordon, GA 30905 USA. EM john.s.earwood.civ@mail.mil NR 18 TC 3 Z9 3 U1 1 U2 7 PU AMER ACAD FAMILY PHYSICIANS PI KANSAS CITY PA 8880 WARD PARKWAY, KANSAS CITY, MO 64114-2797 USA SN 0002-838X EI 1532-0650 J9 AM FAM PHYSICIAN JI Am. Fam. Physician PD FEB 15 PY 2015 VL 91 IS 4 BP 243 EP 249 PG 7 WC Primary Health Care; Medicine, General & Internal SC General & Internal Medicine GA CC0GY UT WOS:000350015000005 PM 25955625 ER PT J AU Lahiri, D Karp, J Keshri, AK Zhang, C Dulikravich, GS Kecskes, LJ Agarwal, A AF Lahiri, Debrupa Karp, Jeffrey Keshri, Anup K. Zhang, Cheng Dulikravich, George S. Kecskes, Laszlo J. Agarwal, Arvind TI Scratch induced deformation behavior of hafnium based bulk metallic glass at multiple load scales SO JOURNAL OF NON-CRYSTALLINE SOLIDS LA English DT Article DE Bulk metallic glass; Hafnium; Multi-scale scratch behavior; Shear band structure; Free volume; Strain hardening ID MECHANICAL-BEHAVIOR; AMORPHOUS-ALLOYS; ROOM-TEMPERATURE; WEAR-RESISTANCE; FORMING ABILITY; STRAIN-RATE; NANO-SCALE; INDENTATION; NANOCRYSTALLIZATION; CRYSTALLIZATION AB The scratch induced deformation behavior of Hafnium based bulk metallic glass (BMG) at micro- and macro-load scales is reported in this study. The micro-scratch deals with a normal load range of 1000-8000 mu N, whereas the macro-scale scratches are made with a normal load reaching up to 5 N. Increase in the load beyond 2000 mu N changes the deformation mechanism from plowing to fracture and chipping. The plastic strain is mostly accommodated by shear band formation with a significant amount of free volume generation. A change in the strain rate helps in the nucleation of shear bands and prevents fracture and chipping in the case of micro-scratches made at ramp loading as compared to constant load. Higher strain rate and heat generation in the track causes increased strain hardening in macro-scratch, which could be attributed to increased probability of nano-crystallization. Complex shear band structure is evolved during scratching, which is attributed to the mixed type of loading, consisting of compressive normal load and lateral shear load across scratch-track. (C) 2014 Elsevier B.V. All rights reserved. C1 [Lahiri, Debrupa; Karp, Jeffrey; Keshri, Anup K.; Zhang, Cheng; Agarwal, Arvind] Florida Int Univ, Nanomech & Nanotribol Lab, Miami, FL 33174 USA. [Dulikravich, George S.] Florida Int Univ, MAIDROC, Miami, FL 33174 USA. [Kecskes, Laszlo J.] US Army, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Agarwal, A (reprint author), Florida Int Univ, Nanomech & Nanotribol Lab, Miami, FL 33174 USA. EM agarwala@fiu.edu FU US Army Research Office [W911NF-06-1-0328] FX AA and DL acknowledge support of AMERI at FIU, in maintaining and providing the research facilities. The authors acknowledge the help from Prof. Todd C. Hufnagel at Johns Hopkins University for synthesizing Hf based BMG samples. GSD and M also acknowledge the research grant W911NF-06-1-0328 from US Army Research Office. NR 35 TC 0 Z9 0 U1 4 U2 16 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0022-3093 EI 1873-4812 J9 J NON-CRYST SOLIDS JI J. Non-Cryst. Solids PD FEB 15 PY 2015 VL 410 BP 118 EP 126 DI 10.1016/j.jnoncrysol.2014.12.010 PG 9 WC Materials Science, Ceramics; Materials Science, Multidisciplinary SC Materials Science GA CB6HA UT WOS:000349726900019 ER PT J AU Paris, DH Chattopadhyay, S Jiang, J Nawtaisong, P Lee, JS Tan, E Dela Cruz, E Burgos, J Abalos, R Blacksell, SD Lombardini, E Turner, GD Day, NPJ Richards, AL AF Paris, Daniel H. Chattopadhyay, Suchismita Jiang, Ju Nawtaisong, Pruksa Lee, John S. Tan, Esterlina Dela Cruz, Eduardo Burgos, Jasmin Abalos, Rodolfo Blacksell, Stuart D. Lombardini, Eric Turner, Gareth D. Day, Nicholas P. J. Richards, Allen L. TI A Nonhuman Primate Scrub Typhus Model: Protective Immune Responses Induced by pKarp47 DNA Vaccination in Cynomolgus Macaques SO JOURNAL OF IMMUNOLOGY LA English DT Article ID ENCEPHALITIS-VIRUS REPLICON; SILVERED LEAF MONKEYS; RICKETTSIA-TSUTSUGAMUSHI; ORIENTIA-TSUTSUGAMUSHI; PRESBYTIS-CRISTATUS; MACACA-FASCICULARIS; GAMMA-INTERFERON; GUINEA-PIGS; INFECTION; VACCINES AB We developed an intradermal (ID) challenge cynomolgus macaque (Macaca fascicularis) model of scrub typhus, the leading cause of treatable undifferentiated febrile illness in tropical Asia, caused by the obligate intracellular bacterium, Orientia tsutsugamushi. A well-characterized animal model is required for the development of clinically relevant diagnostic assays and evaluation of therapeutic agents and candidate vaccines. We investigated scrub typhus disease pathophysiology and evaluated two O. tsutsugamushi 47-kDa, Ag-based candidate vaccines, a DNA plasmid vaccine (pKarp47), and a virus-vectored vaccine (Kp47/47-Venezuelan equine encephalitis virus replicon particle) for safety, immunogenicity, and efficacy against homologous ID challenge with O. tsutsugamushi Karp. Control cynomolgus macaques developed fever, classic eschars, lymphadenopathy, bacteremia, altered liver function, increased WBC counts, pathogen-specific Ab (IgM and IgG), and cell-mediated immune responses. Vaccinated macaques receiving the DNA plasmid pKarp47 vaccine had significantly increased O. tsutsugamushi-specific, IFN-gamma-producing PBMCs (p = 0.04), reduced eschar frequency and bacteremia duration (p <= 0.01), delayed bacteremia onset (p < 0.05), reduced circulating bacterial biomass (p = 0.01), and greater reduction of liver transaminase levels (p < 0.03) than controls. This study demonstrates a vaccine-induced immune response capable of conferring sterile immunity against high-dose homologous ID challenge of O. tsutsugamushi in a nonhuman primate model, and it provides insight into cell-mediated immune control of O. tsutsugamushi and dissemination dynamics, highlights the importance of bacteremia indices for evaluation of both natural and vaccine-induced immune responses, and importantly, to our knowledge, has determined the first phenotypic correlates of immune protection in scrub typhus. We conclude that this model is suitable for detailed investigations into vaccine-induced immune responses and correlates of immunity for scrub typhus. C1 [Paris, Daniel H.; Nawtaisong, Pruksa; Blacksell, Stuart D.; Turner, Gareth D.; Day, Nicholas P. J.] Mahidol Univ, Fac Trop Med, Mahidol Oxford Trop Med Res Unit, Bangkok 10400, Thailand. [Paris, Daniel H.; Blacksell, Stuart D.; Turner, Gareth D.; Day, Nicholas P. J.] Univ Oxford, Nuffield Dept Clin Med, Ctr Trop Med & Global Hlth, Oxford OX3 7FZ, England. [Chattopadhyay, Suchismita; Jiang, Ju; Richards, Allen L.] Naval Med Res Ctr, Viral & Rickettsial Dis Dept, Silver Spring, MD 20910 USA. [Lee, John S.] Walter Reed Army Inst Res, Div Entomol, Silver Spring, MD 20910 USA. [Tan, Esterlina; Dela Cruz, Eduardo; Burgos, Jasmin; Abalos, Rodolfo] Leonard Wood Mem Inst, Cebu 6000, Philippines. [Lombardini, Eric] Armed Forces Med Res Inst Sci, Dept Vet Med, Bangkok 10400, Thailand. [Richards, Allen L.] Uniformed Serv Univ Hlth Sci, Dept Prevent Med & Biometr, Bethesda, MD 20814 USA. RP Paris, DH (reprint author), Mahidol Univ, Fac Trop Med, Mahidol Oxford Trop Med Res Unit, 3rd Floor,60th Anniversary Chalermprakiat Bldg, Bangkok 10400, Thailand. EM parigi@tropmedres.ac OI Blacksell, Stuart/0000-0001-6576-726X; PARIS, Daniel/0000-0003-4743-5987 FU Department of Defense, Military Infectious Diseases Research Program Work Unit [6000.RAD1.J.A0310]; Wellcome Trust of Great Britain [089275/Z/09/Z]; Wellcome Trust Clinical Research Training Fellowship [078990/Z/06/Z] FX This work was supported by the Department of Defense, Military Infectious Diseases Research Program Work Unit 6000.RAD1.J.A0310, the Wellcome Trust of Great Britain (Grant 089275/Z/09/Z), and a Wellcome Trust Clinical Research Training Fellowship (Grant 078990/Z/06/Z to D.H.P.). NR 65 TC 6 Z9 6 U1 0 U2 5 PU AMER ASSOC IMMUNOLOGISTS PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 0022-1767 EI 1550-6606 J9 J IMMUNOL JI J. Immunol. PD FEB 15 PY 2015 VL 194 IS 4 BP 1702 EP 1716 DI 10.4049/jimmunol.1402244 PG 15 WC Immunology SC Immunology GA CB2MP UT WOS:000349462000034 PM 25601925 ER PT J AU Middlemas, S Fang, ZZ Fan, P AF Middlemas, Scott Fang, Z. Zak Fan, Peng TI Life cycle assessment comparison of emerging and traditional Titanium dioxide manufacturing processes SO JOURNAL OF CLEANER PRODUCTION LA English DT Article DE Titanium dioxide; Energy analysis; LCA; Chloride process; Sulfate process; Altairnano process ID SODIUM-HYDROXIDE; SLAG; DECOMPOSITION; PIGMENT; ILMENITE; CELLS; METAL AB Titanium dioxide (TiO2) is used as pigment in a wide variety of domestic and industrial applications, and is becoming an increasingly valuable nanomaterial. TiO2 is manufactured by the traditional sulfate process or high temperature chloride process. Several hydrometallurgical processes for manufacturing TiO2 have recently emerged to reduce the environmental impact of TiO2 production. A new process is reported that features alkaline roasting of titania slag (ARTS), with subsequent washing, leaching, solvent extraction, hydrolysis, and calcination stages, and implements the recycling and regeneration of alkaline and acid process streams to minimize waste generation. A virtual ARTS processing plant is described in detail and is used to conduct an LCA comparison with the sulfate, chloride, and Altairnano processes. The cumulative energy demand (CED) and total CO2 emissions for the ARTS process are 92.6 MJ/kg TiO2 and 7.47 kg CO2/kg TiO2, respectively, which compares favorably with the traditional and Altairnano processes. (C) 2014 Elsevier Ltd. All rights reserved. C1 [Middlemas, Scott; Fang, Z. Zak; Fan, Peng] Univ Utah, Dept Met Engn, Salt Lake City, UT 84112 USA. [Middlemas, Scott] US Army Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. RP Middlemas, S (reprint author), US Army Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. EM scott.middlemas.ctr@mail.mil OI Middlemas, Scott/0000-0003-0133-7126 FU US Department of Energy; Office of Energy Efficiency and Renewable Energy [DE-EE003476]; U.S. Army Research Laboratory (ARL) FX The US Department of Energy and the Office of Energy Efficiency and Renewable Energy is acknowledged for funding this research (DE-EE003476). The authors also thank Rio Tinto Iron and Titanium for providing raw materials for the experimental portion of this study. The authors would also like to acknowledge Mike Lefler, Matt Ludwig, Prashant Bagri, Brent Randall, and Randy Crossman for their assistance in the development of the process flow sheet. S.M. would like to acknowledge support from the U.S. Army Research Laboratory (ARL) administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the U.S. Department of Energy and ARL. NR 50 TC 5 Z9 6 U1 5 U2 45 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0959-6526 EI 1879-1786 J9 J CLEAN PROD JI J. Clean Prod. PD FEB 15 PY 2015 VL 89 BP 137 EP 147 DI 10.1016/j.jclepro.2014.11.019 PG 11 WC GREEN & SUSTAINABLE SCIENCE & TECHNOLOGY; Engineering, Environmental; Environmental Sciences SC Science & Technology - Other Topics; Engineering; Environmental Sciences & Ecology GA CA5TH UT WOS:000348970200014 ER PT J AU Kalambate, PK Dar, RA Karna, SP Srivastava, AK AF Kalambate, Pramod K. Dar, Riyaz A. Karna, Shashi P. Srivastava, Ashwini K. TI High performance supercapacitor based on graphene-silver nanoparticles-polypyrrole nanocomposite coated on glassy carbon electrode SO JOURNAL OF POWER SOURCES LA English DT Article DE Graphene; Silver nanoparticles; Polypyrrole; Supercapacitor; Energy density ID CONDUCTING-POLYMER; ELECTROCHEMICAL SUPERCAPACITORS; OXIDE/POLYPYRROLE COMPOSITE; ENERGY-STORAGE; POLYANILINE; NANOTUBES; DENSITY; OXIDE; FABRICATION; CAPACITANCE AB In the current study, we present a new hybrid material of double layer capacitive material graphene (GNS), pseudo capacitive polypyrrole (PPY) and highly conducting silver nanoparticles (AgNPs). Graphene/Silver nanoparticles/polypyrrole (GNS/AgNPs/PPY) composite has been synthesized by in situ oxidative polymerization of pyrrole in the presence of GNS and AgNPs. The different mass concentrations of AgNPs were utilized to improve the capacitive performance of supercapacitor. Characterization of the electrode material has been carried out by X-ray diffraction, Raman spectroscopy, Thermal methods, Scanning electron microscopy (SEM) and Transmission electron microscopy. SEM images showed that PPY nanoparticles uniformly coated on graphene sheets along with AgNPs. Electrochemical characterization of the electrode surface has been carried out by means of cyclic voltammetry, galvanostatic charge/discharge and electrochemical impedance spectroscopy. Remarkably, GNS/AgNPs/PPY exhibits specific capacitance of 450 F g(-1) at current density of 0.9 mA g(-1), which is far better than GNS/PPY (288 F g(-1)), AgNPs/PPY (216 F g(-1)) and PPY (153 F g(-1)). Furthermore, GNS/AgNPs/PPY shows high charge discharge reversibility and retaining over 92.0% of its initial value after 1000 cycles. The cyclic stability of the composite is improved due to the synergistic effect of GNS, AgNPs and PPY. (C) 2014 Elsevier B.V. All rights reserved. C1 [Kalambate, Pramod K.; Dar, Riyaz A.; Srivastava, Ashwini K.] Univ Mumbai, Dept Chem, Bombay 400098, Maharashtra, India. [Karna, Shashi P.] US Army, Res Lab, Weap & Mat Res Directorate, ATTN RDRL WM, Aberdeen Proving Ground, MD 21005 USA. RP Srivastava, AK (reprint author), Univ Mumbai, Dept Chem, Bombay 400098, Maharashtra, India. EM aksrivastava@chem.mu.ac.in OI Dar, Riyaz/0000-0002-4494-0702 FU US Army International Technology Center, Pacific Asia Countries, Tokyo, Japan [FA2386-12-1-4086] FX This research was funded by the US Army International Technology Center, Pacific Asia Countries, Tokyo, Japan through contract number FA2386-12-1-4086. NR 48 TC 28 Z9 28 U1 24 U2 227 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0378-7753 EI 1873-2755 J9 J POWER SOURCES JI J. Power Sources PD FEB 15 PY 2015 VL 276 BP 262 EP 270 DI 10.1016/j.jpowsour.2014.11.130 PG 9 WC Chemistry, Physical; Electrochemistry; Energy & Fuels; Materials Science, Multidisciplinary SC Chemistry; Electrochemistry; Energy & Fuels; Materials Science GA CA2OJ UT WOS:000348747200035 ER PT J AU Clayton, JD Knap, J AF Clayton, J. D. Knap, J. TI Phase field modeling of directional fracture in anisotropic polycrystals SO COMPUTATIONAL MATERIALS SCIENCE LA English DT Article DE Phase field; Fracture; Polycrystal; Anisotropy; Energy minimization ID BRITTLE-FRACTURE; NUMERICAL EXPERIMENTS; HCP METALS; GRAIN-SIZE; DEFORMATION; SOLIDS; ZINC; FRAGMENTATION; SIMULATION; PLASTICITY AB A phase field theory for modeling deformation and fracture of single crystals, polycrystals, and grain boundaries is developed. Anisotropies of elastic coefficients and fracture surface energy are addressed, the latter enabling favorable cleavage on intrinsically weak planes in crystals. An order parameter increases in value as damage accumulates in an element of material. The shear elastic coefficients deteriorate with cumulative damage regardless of local strain state, while the effective bulk modulus degrades only under tensile volumetric deformation. Governing equations and boundary conditions are derived using variational methods. An incremental energy minimization approach is used to predict equilibrium crack morphologies in finite element simulations of deforming polycrystals. Thin layers of material, representative of glassy second phases near grain boundaries, are assigned possibly different properties than surrounding crystals. Results of simulations of polycrystals subjected to tensile loading are reported, with base properties representative of silicon carbide or zinc. Key findings include (i) a tendency for intergranular over transgranular fracture as the grain boundary surface energy is reduced or as cleavage anisotropy is increased and (ii) an increase in overall ductility and strength, the latter similar to Hall-Petch scaling, as the absolute size of the polycrystal is reduced while holding the ratio of phase field regularization length to grain size fixed. Published by Elsevier B.V. C1 [Clayton, J. D.] US Army, Impact Phys RDRL WMP C, Res Lab, Aberdeen Proving Ground, MD 21005 USA. [Knap, J.] US Army, Computat Sci RDRL CIH C, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Clayton, JD (reprint author), US Army, Impact Phys RDRL WMP C, Res Lab, Aberdeen Proving Ground, MD 21005 USA. EM john.d.clayton1.civ@mail.mil; jaroslaw.knap.civ@mail.mil RI Clayton, John/C-7760-2009 NR 57 TC 7 Z9 7 U1 7 U2 46 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0927-0256 EI 1879-0801 J9 COMP MATER SCI JI Comput. Mater. Sci. PD FEB 15 PY 2015 VL 98 BP 158 EP 169 DI 10.1016/j.commatsci.2014.11.009 PG 12 WC Materials Science, Multidisciplinary SC Materials Science GA AX1WC UT WOS:000346733000025 ER PT J AU Rivas, M Vyas, V Carter, A Veronick, J Khan, Y Kolosov, OV Polcawich, RG Huey, BD AF Rivas, Manuel Vyas, Varun Carter, Aliya Veronick, James Khan, Yusuf Kolosov, Oleg V. Polcawich, Ronald G. Huey, Bryan D. TI Nanoscale mapping of in situ actuating microelectromechanical systems with AFM SO JOURNAL OF MATERIALS RESEARCH LA English DT Article ID QUARTZ TUNING FORK; ADAPTIVE OPTICS; MEMS TECHNOLOGY; DYNAMIC-BEHAVIOR; SHEAR-FORCE; THIN-FILMS; SENSOR; MICROSCOPY; DEVICES; MICROFLUIDICS AB Microelectromechanical systems (MEMS) are increasingly at our fingertips. To understand and thereby improve their performance, especially given their ever-decreasing sizes, it is crucial to measure their functionality in situ. Atomic force microscopy (AFM) is well suited for such studies, allowing nanoscale lateral and vertical resolution of static displacements, as well as mapping of the dynamic response of these physically actuating microsystems. In this work, the vibration of a tuning fork based viscosity sensor is mapped and compared to model experiments in air, liquid, and a curing collagen gel. The switching response of a MEMS switch with nanosecond time-scale activation is also monitored - including mapping resonances of the driving microcantilever and the displacement of an overhanging contact structure in response to periodic pulsing. Such nanoscale in situ AFM investigations of MEMS can be crucial for enhancing modeling, design, and the ultimate performance of these increasingly important and sophisticated devices. C1 [Rivas, Manuel; Vyas, Varun; Carter, Aliya; Huey, Bryan D.] Univ Connecticut, Dept Mat Sci & Engn, Storrs, CT 06269 USA. [Veronick, James; Khan, Yusuf] Univ Connecticut, Dept Orthopaed Surg, Ctr Hlth, Farmington, CT 06030 USA. [Kolosov, Oleg V.] Univ Lancaster, Dept Phys, Lancaster LA1 4YB, England. [Polcawich, Ronald G.] US Army Res Lab, Micro & Nano Elect Mat & Devices Branch, Adelphi, MD 20783 USA. RP Huey, BD (reprint author), Univ Connecticut, Dept Mat Sci & Engn, Storrs, CT 06269 USA. EM bhuey@ims.uconn.edu RI Kolosov, Oleg/D-3815-2013; OI Kolosov, Oleg/0000-0003-3278-9643; Huey, Bryan/0000-0002-1441-1180 FU Northeast LSAMP Bridge to the Doctorate (BD) program, NSF [EHR 1249283]; University of Connecticut Provosts fund; EPSRC [EP/K023373/1]; Lancaster University; DOD:PECASE FX Support for MR is provided by the Northeast LSAMP Bridge to the Doctorate (BD) program, NSF:EHR 1249283; for VV, JV, YK, and BDH by the University of Connecticut Provosts fund; for OVK from Lancaster University and EPSRC grant EP/K023373/1; and for RP from DOD:PECASE. MEMS specimens are gratefully acknowledged from Jeffrey S. Pulskamp and Robert M. Proie, ARL. NR 68 TC 0 Z9 0 U1 4 U2 16 PU CAMBRIDGE UNIV PRESS PI NEW YORK PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA SN 0884-2914 EI 2044-5326 J9 J MATER RES JI J. Mater. Res. PD FEB 14 PY 2015 VL 30 IS 3 BP 429 EP 441 DI 10.1557/jmr.2014.353 PG 13 WC Materials Science, Multidisciplinary SC Materials Science GA CB9TO UT WOS:000349976100012 ER PT J AU Alem, F Yao, K Lane, D Calvert, V Petricoin, EE Kramer, L Hale, ML Bavari, S Panchal, RG Hakami, RM AF Alem, Farhang Yao, Kuan Lane, Douglas Calvert, Valerie Petricoin, Emanuel E. Kramer, Liana Hale, Martha L. Bavari, Sina Panchal, Rekha G. Hakami, Ramin M. TI Host response during Yersinia pestis infection of human bronchial epithelial cells involves negative regulation of autophagy and suggests a modulation of survival-related and cellular growth pathways SO FRONTIERS IN MICROBIOLOGY LA English DT Article DE RPMA; Yersinia pestis; host response; signaling pathways; apoptosis and autophagy; phosphorylation changes; cell growth; proteomics ID MURINE PERITONEAL-MACROPHAGES; SIGNAL-TRANSDUCTION PATHWAYS; PROTEIN-KINASE-A; NF-KAPPA-B; INDUCED APOPTOSIS; C-MYC; TRANSCRIPTION FACTOR; MORPHOLOGICAL-CHANGES; MAMMALIAN-CELLS; III SECRETION AB Yersinia pestis (Yp) causes the re-emerging disease plague, and is classified by the CDC and NIAID as a highest priority (Category A) pathogen. Currently, there is no approved human vaccine available and advances in early diagnostics and effective therapeutics are urgently needed. A deep understanding of the mechanisms of host response to Yp infection can significantly advance these three areas. We employed the Reverse Phase Protein Microarray (RPMA) technology to reveal the dynamic states of either protein level changes or phosphorylation changes associated with kinase-driven signaling pathways during host cell response to Yp infection. RPMA allowed quantitative profiling of changes in the intracellular communication network of human lung epithelial cells at different times post infection and in response to different treatment conditions, which included infection with the virulent Yp strain CO92, infection with a derivative avirulent strain CO92 (Pgm-, Pst-), treatment with heat inactivated CO92, and treatment with LPS. Responses to a total of 111 validated antibodies were profiled, leading to discovery of 12 novel protein hits. The RPMA analysis also identified several protein hits previously reported in the context of Yp infection. Furthermore, the results validated several proteins previously reported in the context of infection with other Yersinia species or implicated for potential relevance through recombinant protein and cell transfection studies. The RPMA results point to strong modulation of survival/apoptosis and cell growth pathways during early host response and also suggest a model of negative regulation of the autophagy pathway. We find significant cytoplasmic localization of p53 and reduced LC3-I to LC3-II conversion in response to Yp infection, consistent with negative regulation of autophagy. These studies allow for a deeper understanding of the pathogenesis mechanisms and the discovery of innovative approaches for prevention, early diagnosis, and treatment of plague. C1 [Alem, Farhang; Yao, Kuan; Kramer, Liana; Hakami, Ramin M.] George Mason Univ, Natl Ctr Biodefense & Infect Dis, Manassas, VA 20110 USA. [Alem, Farhang; Yao, Kuan; Kramer, Liana; Hakami, Ramin M.] George Mason Univ, Sch Syst Biol, Manassas, VA 20110 USA. [Lane, Douglas; Hale, Martha L.; Bavari, Sina; Panchal, Rekha G.] US Army Med Res Inst Infect Dis, Frederick, MD USA. [Calvert, Valerie; Petricoin, Emanuel E.] George Mason Univ, Sch Syst Biol, Ctr Appl Prote & Mol Med, Manassas, VA USA. RP Hakami, RM (reprint author), George Mason Univ, Natl Ctr Biodefense & Infect Dis, 10650 Pyramid Pl, Manassas, VA 20110 USA. EM rhakami@gmu.edu FU U.S. Army Medical Research and Materiel Command [W81XWH-11-P-0310]; George Mason University FX This work was supported by funding awarded by the U.S. Army Medical Research and Materiel Command (W81XWH-11-P-0310) and George Mason University to Ramin M. Hakami. NR 93 TC 2 Z9 2 U1 0 U2 7 PU FRONTIERS RESEARCH FOUNDATION PI LAUSANNE PA PO BOX 110, LAUSANNE, 1015, SWITZERLAND SN 1664-302X J9 FRONT MICROBIOL JI Front. Microbiol. PD FEB 13 PY 2015 VL 6 AR 50 DI 10.3389/fmicb.2015.00050 PG 14 WC Microbiology SC Microbiology GA CC3AM UT WOS:000350216500001 PM 25762983 ER PT J AU Liu, RF Yu, XP Wallqvist, A AF Liu, Ruifeng Yu, Xueping Wallqvist, Anders TI Data-driven identification of structural alerts for mitigating the risk of drug-induced human liver injuries SO JOURNAL OF CHEMINFORMATICS LA English DT Article DE Drug-induced liver injury; Hepatotoxicity; Structure alert; Bioactivation; Reactive metabolite ID STRUCTURE-TOXICITY RELATIONSHIPS; HOSPITALIZED-PATIENTS; HEPATOTOXICITY; BIOACTIVATION; METABOLISM; PROGRESS AB Background: The use of structural alerts to de-prioritize compounds with undesirable features as drug candidates has been gaining in popularity. Hundreds of molecular structural moieties have been proposed as structural alerts. An emerging issue is that strict application of these alerts will result in a significant reduction of the chemistry space for new drug discovery, as more than half of the oral drugs on the market match at least one of the alerts. To mitigate this issue, we propose to apply a rigorous statistical analysis to derive/validate structural alerts before use. Method: To derive human liver toxicity structural alerts, we retrieved all small-molecule entries from LiverTox, a U.S. National Institutes of Health online resource for information on human liver injuries induced by prescription and over-the-counter drugs and dietary supplements. We classified the compounds into hepatotoxic, nonhepatotoxic, and possible hepatotoxic classes, and performed detailed statistical analyses to identify molecular structural fragments highly enriched in the hepatotoxic class beyond random distribution as structural alerts for human liver injuries. Results: We identified 12 molecular fragments present in multiple marketed drugs that one can consider as common "drug-like" fragments, yet they are strongly associated with drug-induced human liver injuries. Thus, these fragments may be considered as robust hepatotoxicity structural alerts suitable for use in drug discovery screening programs. Conclusions: The use of structural alerts has contributed to the identification of many compounds with potential toxicity issues in modern drug discovery. However, with a large number of structural alerts published to date without proper validation, application of these alerts may restrict the chemistry space and prevent discovery of valuable drugs. To mitigate this issue, we showed how to use statistical analyses to develop a small, robust, and broadly applicable set of structural alerts. C1 [Liu, Ruifeng; Yu, Xueping; Wallqvist, Anders] US Army, Med Res & Mat Command, Telemed & Adv Technol Res Ctr, Software Applicat Inst,Dept Def Biotechnol High P, Ft Detrick, MD 21702 USA. RP Liu, RF (reprint author), US Army, Med Res & Mat Command, Telemed & Adv Technol Res Ctr, Software Applicat Inst,Dept Def Biotechnol High P, 2405 Whittier Dr, Ft Detrick, MD 21702 USA. EM rliu@bhsai.org; awallqvist@bhsai.org OI wallqvist, anders/0000-0002-9775-7469 FU U.S. Army Medical Research and Materiel Command (Ft. Detrick, MD), U.S. Army's Network Science Initiative; Defense Threat Reduction Agency grant [CBCall14-CBS-05-2-0007] FX The authors were supported by the U.S. Army Medical Research and Materiel Command (Ft. Detrick, MD) as part of the U.S. Army's Network Science Initiative, and by the Defense Threat Reduction Agency grant CBCall14-CBS-05-2-0007. The opinions and assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the U.S. Army or of the U.S. Department of Defense. This paper has been approved for public release with unlimited distribution. NR 24 TC 6 Z9 6 U1 3 U2 6 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1758-2946 J9 J CHEMINFORMATICS JI J. Cheminformatics PD FEB 11 PY 2015 VL 7 AR 4 DI 10.1186/s13321-015-0053-y PG 8 WC Chemistry, Multidisciplinary; Computer Science, Information Systems; Computer Science, Interdisciplinary Applications SC Chemistry; Computer Science GA CC5XS UT WOS:000350438900001 PM 25717346 ER PT J AU Masser, KA Knorr, DB Hindenlang, MD Yu, JH Richardson, AD Strawhecker, KE Beyer, FL Lenhart, JL AF Masser, Kevin A. Knorr, Daniel B., Jr. Hindenlang, Mark D. Yu, Jian H. Richardson, Adam D. Strawhecker, Kenneth E. Beyer, Frederick L. Lenhart, Joseph L. TI Relating structure and chain dynamics to ballistic performance in transparent epoxy networks exhibiting nanometer scale heterogeneity SO POLYMER LA English DT Article DE Polymer networks; Nanoscale heterogeneity; Nanostructure ID X-RAY-SCATTERING; SMALL-ANGLE SCATTERING; HIGH-STRAIN RATES; MOLECULAR-WEIGHT; SEGMENTED POLYURETHANES; RELAXATION PROCESSES; PHASE INVERSION; BEHAVIOR; BLENDS; MORPHOLOGY AB The ballistic performance was examined for a series of broad glass transition temperature epoxy formulations consisting of a di-epoxy monomer crosslinked with bi-modal mixtures of both a rigid, low molecular weight diamine and a flexible, high molecular weight diamine. Interestingly, the resins did not macro-phase separate during cure, but exhibited structural and dynamic heterogeneity on a length scale of a few nanometers, as confirmed by X-ray scattering, dynamic mechanical analysis, modulus-mapped atomic force microscopy, and broadband dielectric spectroscopy. The nano-structured resins were optically transparent and demonstrated a nearly 300% increase in ballistic energy dissipation relative to the neat resins, as well as when compared to epoxy formulations composed of similar bi-modal blends that exhibited a macro-phase separated structure. The ballistic performance is found to be insensitive to sub-glass transition temperature (T-g) relaxations, but appears to be dependent on both the nano-structure and the Vogel temperature of the high T-g component. The study demonstrates a new class of transparent protective materials composed of rigid and flexible components with a fine scale heterogeneous structure. Published by Elsevier Ltd. C1 [Masser, Kevin A.; Knorr, Daniel B., Jr.; Hindenlang, Mark D.; Yu, Jian H.; Richardson, Adam D.; Strawhecker, Kenneth E.; Beyer, Frederick L.; Lenhart, Joseph L.] US Army, Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. RP Lenhart, JL (reprint author), US Army, Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. EM Joseph.l.lenhart.civ@mail.mil FU ORISE Postdoctoral Research Program; Army Research Laboratory FX MDH and ADR acknowledge the ORISE Postdoctoral Research Program and the Army Research Laboratory for funding. The authors thank Ian McAninch for providing infrared data on the neat epoxy materials. NR 59 TC 6 Z9 6 U1 5 U2 41 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0032-3861 EI 1873-2291 J9 POLYMER JI Polymer PD FEB 10 PY 2015 VL 58 BP 96 EP 106 DI 10.1016/j.polymer.2014.12.027 PG 11 WC Polymer Science SC Polymer Science GA CB4II UT WOS:000349591000013 ER PT J AU Sirk, TW Karim, M Khare, KS Lenhart, JL Andzelm, JW Khare, R AF Sirk, Timothy W. Karim, Mir Khare, Ketan S. Lenhart, Joseph L. Andzelm, Jan W. Khare, Rajesh TI Bi-modal polymer networks: Composition-dependent trends in thermal, volumetric and structural properties from molecular dynamics simulation SO POLYMER LA English DT Article DE Molecular dynamics; Mixed network; Glass transition ID CROSS-LINKED EPOXY; GLASS-TRANSITION; EFFICIENT GENERATION; AM1-BCC MODEL; FORCE-FIELD; TEMPERATURE; BEHAVIOR; LIQUIDS; RESINS AB Thermal and volumetric properties of mixed epoxy networks were characterized with molecular dynamics simulation. Atomistically detailed models of epoxy networks of diglycidyl ether of bisphenol (DGEBA) cured with stoichiometric binary mixtures of a flexible cross-linker poly(oxypropylene) diamine (POP) and a stiff cross-linker 4,4 '-methylenebis(cyclohexylamine) (MCA), having molecular weights of 1987 and 210 g/mol respectively, were prepared. Epoxy networks formed by five different compositions of the cross-linkers ranging from pure POP to pure MCA were constructed, and a network topology analysis was carried out to verify that each network chain was connected to all other chains by a path of bonded molecules. The glass transition temperature (T-g), coefficient of volume thermal expansion (CVTE), heat capacity and thermal conductivity of these network structures were determined as a function of the network composition. The simulated values of these properties are compared with predictions from theories, empirical correlations and experiments from the literature. In general, it is observed that an increase in the mass fraction of MCA leads to an increase in the T-g and a decrease in the CVTE; furthermore, the breadth of the transition as exhibited by the change in the specific volume, CVTE, and heat capacity increases with an increase in the MCA content. The differences in the flexibility of the network components were analyzed using a number of quantitative measures. Using these results, a molecular mechanism is proposed for the observation of the network composition dependence of the breadth of the glass transition in these systems. (C) 2015 Elsevier Ltd. All rights reserved. C1 [Sirk, Timothy W.; Lenhart, Joseph L.; Andzelm, Jan W.] US Army Res Lab, Macromol Sci & Technol Branch, Aberdeen Proving Ground, MD USA. [Karim, Mir; Khare, Ketan S.; Khare, Rajesh] Texas Tech Univ, Dept Chem Engn, Lubbock, TX 79409 USA. RP Sirk, TW (reprint author), TKC Global, 2100 Muir Way, Bel Air, MD 21015 USA. EM tim.sirk@us.army.mil; rajesh.khare@ttu.edu RI Khare, Ketan/C-6074-2012; Khare, Rajesh/J-2079-2014 OI Khare, Ketan/0000-0002-5487-5553; Khare, Rajesh/0000-0002-8859-766X FU U.S. Army/Battelle Memorial Institute [US0010000287704]; U.S. Army Research Laboratory [W911QX-14-C-0016] FX The authors thank Sindee Simon for insightful discussions on the temperature dependence of the heat capacity. The work of MK, KSK, and RK was supported by U.S. Army/Battelle Memorial Institute contract number US0010000287704. The research reported in this document was also performed in connection with contract/instrument W911QX-14-C-0016 with the U.S. Army Research Laboratory. NR 45 TC 7 Z9 7 U1 2 U2 29 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0032-3861 EI 1873-2291 J9 POLYMER JI Polymer PD FEB 10 PY 2015 VL 58 BP 199 EP 208 DI 10.1016/j.polymer.2014.12.057 PG 10 WC Polymer Science SC Polymer Science GA CB4II UT WOS:000349591000025 ER PT J AU Zhang, ZL Sun, BW Johnson, BE AF Zhang, Zhonglong Sun, Bowen Johnson, Billy E. TI Integration of a benthic sediment diagenesis module into the two dimensional hydrodynamic and water quality model - CE-QUAL-W2 SO ECOLOGICAL MODELLING LA English DT Review DE CE-QUAL-W2; Water quality; Sediment oxygen demand; Nutrient release; Organic matter; Sediment diagenesis AB Current CE-QUAL-W2 mainly simulates hydrodynamics and eutrophication processes in the water column. The benthic sediment processes and sediment-water interactions have been neglected or very much simplified using zero-order and first-order rates. In this study a benthic sediment diagenesis module was developed and integrated into CE-QUAL-W2. Enhanced CE-QUAL-W2 was capable of simulating the dynamic releases of ammonium, nitrate, phosphorus, dissolved silica and dissolved methane from the sediment to the overlying water, as well as benthic sediment oxygen demand. The oxidation of sulfides is included for salt water sediments. The ability of CE-QUAL-W2 model to correctly predict sediment-water nutrient fluxes and sediment oxygen demand was evaluated against SedFlux and CE-QUAL-ICM models through a series of case studies. These case studies were chosen for representing various sedimentation and environmental conditions. The simulated sediment-water nutrient fluxes and sediment oxygen demand over time were generally in good agreement with these two model results for all data sets. The effect of benthic sediment diffusive thickness, particle mixing coefficients on nutrient releases from sediments and sediment oxygen demand were examined. Enhanced CE-QUAL-W2 model was also applied to the Lower Minnesota River for further evaluating its performance. This paper presents the sediment diagenesis module development, validation tests and application of the enhanced CE-QUAL-W2 model. (C) 2014 Elsevier B.V. All rights reserved. C1 [Zhang, Zhonglong] US Army, Engineer Res & Dev Ctr, Environm Lab, BTS, Vicksburg, MS 39180 USA. [Sun, Bowen] Tianjin Univ, State Key Lab Hydraul Engn Simulat & Safety, Tianjin 300072, Peoples R China. [Johnson, Billy E.] US Army, Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA. RP Zhang, ZL (reprint author), US Army, Engineer Res & Dev Ctr, Environm Lab, BTS, Vicksburg, MS 39180 USA. EM zhonglong.zhang@erdc.dren.mil NR 15 TC 3 Z9 3 U1 4 U2 29 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0304-3800 EI 1872-7026 J9 ECOL MODEL JI Ecol. Model. PD FEB 10 PY 2015 VL 297 BP 213 EP 231 DI 10.1016/j.ecolmodel.2014.10.025 PG 19 WC Ecology SC Environmental Sciences & Ecology GA CB1ZA UT WOS:000349425300023 ER PT J AU Redding, B Hill, SC Alexson, D Wang, CJ Pan, YL AF Redding, Brandon Hill, Steven C. Alexson, Dimitri Wang, Chuji Pan, Yong-Le TI Photophoretic trapping of airborne particles using ultraviolet illumination SO OPTICS EXPRESS LA English DT Article ID AIR; MANIPULATION; BACTERIA; FORCES; MOTION; BEAMS; MODEL AB We demonstrate photophoretic trapping of micron-sized absorbing particles in air using pulsed and continuous-wave (CW) ultraviolet laser illumination at wavelengths of 351 nm and 244 nm. We compared the particle trapping dynamics in two trapping geometries consisting of a hollow optical cone formed by light propagating either with or against gravity. This comparison allowed us to isolate the influence of the photophoretic force from the radiative pressure and the convective forces. We found that the absorbing spherical particles tested experienced a positive photophoretic force, whereas the spatially irregular, non-spherical particles tested experienced a negative photophoretic force. By using two trapping geometries, both spherical and non-spherical absorbing particles could be trapped and held securely in place. The position of the trapped particles exhibited a standard deviation of less than 1 mu m over 20 seconds. Moreover, by operating in the UV and deep-UV where the majority of airborne materials are absorptive, the system was able to trap a wide range of particle types. Such a general purpose optical trap could enable on-line characterization of airborne particles when coupled with interrogation techniques such as Raman spectroscopy. (C) 2015 Optical Society of America C1 [Redding, Brandon; Hill, Steven C.; Alexson, Dimitri; Wang, Chuji; Pan, Yong-Le] US Army, Res Lab, Adelphi, MD 20783 USA. [Wang, Chuji] Mississippi State Univ, Starkville, MS 39759 USA. RP Pan, YL (reprint author), US Army, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM yongle.pan.civ@mail.mil FU Defense Threat Reduction Agency (DTRA) [HDTRA136477, HDTRA1310184]; US Army Research Laboratory mission funds; [W911NF-12-2-0019] FX This research was supported by the Defense Threat Reduction Agency (DTRA) under contract number HDTRA136477 and HDTRA1310184, US Army Research Laboratory mission funds, and under Cooperative Agreement Number W911NF-12-2-0019. NR 30 TC 7 Z9 7 U1 4 U2 21 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1094-4087 J9 OPT EXPRESS JI Opt. Express PD FEB 9 PY 2015 VL 23 IS 3 BP 3630 EP 3639 DI 10.1364/OE.23.003630 PG 10 WC Optics SC Optics GA CB5SV UT WOS:000349688800172 PM 25836215 ER PT J AU Foran, CM Baker, KM Grosso, NR Linkov, I AF Foran, Christy M. Baker, Kelsie M. Grosso, Nancy R. Linkov, Igor TI An Enhanced Adaptive Management Approach for Remediation of Legacy Mercury in the South River SO PLOS ONE LA English DT Article AB Uncertainties about future conditions and the effects of chosen actions, as well as increasing resource scarcity, have been driving forces in the utilization of adaptive management strategies. However, many applications of adaptive management have been criticized for a number of shortcomings, including a limited ability to learn from actions and a lack of consideration of stakeholder objectives. To address these criticisms, we supplement existing adaptive management approaches with a decision-analytical approach that first informs the initial selection of management alternatives and then allows for periodic re-evaluation or phased implementation of management alternatives based on monitoring information and incorporation of stakeholder values. We describe the application of this enhanced adaptive management (EAM) framework to compare remedial alternatives for mercury in the South River, based on an understanding of the loading and behavior of mercury in the South River near Waynesboro, VA. The outcomes show that the ranking of remedial alternatives is influenced by uncertainty in the mercury loading model, by the relative importance placed on different criteria, and by cost estimates. The process itself demonstrates that a decision model can link project performance criteria, decision-maker preferences, environmental models, and short- and long-term monitoring information with management choices to help shape a remediation approach that provides useful information for adaptive, incremental implementation. C1 [Foran, Christy M.; Linkov, Igor] US Army Corps Engineers New England Dist, US States Army Engineer Res & Dev Ctr, Duty Stn, Concord, MA 01742 USA. [Baker, Kelsie M.] US States Army Engineer Res & Dev Ctr, Concord, MA 01742 USA. [Grosso, Nancy R.] DuPont Corp, Remediat Grp, Wilmington, DE 19805 USA. RP Linkov, I (reprint author), US Army Corps Engineers New England Dist, US States Army Engineer Res & Dev Ctr, Duty Stn, Concord, MA 01742 USA. EM Igor.Linkov@usace.army.mil FU USACE through Cooperative Research and Development Agreement (CRADA); DuPont FX This study was funded by DuPont and USACE through Cooperative Research and Development Agreement (CRADA). One author, Nancy Grosso, has an affiliation to the commercial funders of this research study (DuPont). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 22 TC 2 Z9 2 U1 0 U2 17 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD FEB 9 PY 2015 VL 10 IS 2 AR e0117140 DI 10.1371/journal.pone.0117140 PG 15 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA CA7UO UT WOS:000349123100019 PM 25665032 ER PT J AU Ratto-Kim, S de Souza, MS Currier, JR Karasavvas, N Sidney, J Rolland, M Valencia-Micolta, A Madnote, S Sette, A Nitayaphan, S Pitisuttuthum, P Kaewkungwal, J Rerks-Ngarm, S O'Connell, R Michael, N Robb, ML Marovich, M Kim, JH AF Ratto-Kim, Silvia de Souza, Mark S. Currier, Jeffrey R. Karasavvas, Nicos Sidney, John Rolland, Morgane Valencia-Micolta, Anais Madnote, Sirinan Sette, Alessandro Nitayaphan, Sorachai Pitisuttuthum, Punnee Kaewkungwal, Jaranit Rerks-Ngarm, Supachai O'Connell, Robert Michael, Nelson Robb, Merlin L. Marovich, Mary Kim, Jerome H. TI Identification of Immunodominant CD4-Restricted Epitopes Co-Located with Antibody Binding Sites in Individuals Vaccinated with ALVAC-HIV and AIDSVAX B/E SO PLOS ONE LA English DT Article ID IMMUNODEFICIENCY-VIRUS TYPE-1; THAI ADULTS; SUBTYPE-B; TRIAL; V2; IMMUNOGENICITY; EFFICACY; ENVELOPE; SAFETY; LOOP AB We performed fine epitope mapping of the CD4+ responses in the ALVAC-HIV-AIDSVAX B/E prime-boost regimen in the Thai Phase III trial (RV144). Non-transformed Env-specific T cell lines established from RV144 vaccinees were used to determine the fine epitope mapping of the V2 and C1 responses and the HLA class II restriction. Data showed that there are two CD4+ epitopes contained within the V2 loop: one encompassing the alpha 4 beta 7 integrin binding site (AA179-181) and the other nested between two previously described genetic sieve signatures (AA169, AA181). There was no correlation between the frequencies of CD4+ fine epitope responses and binding antibody. C1 [Ratto-Kim, Silvia; Currier, Jeffrey R.; Rolland, Morgane; Valencia-Micolta, Anais; Michael, Nelson; Robb, Merlin L.; Kim, Jerome H.] Walter Reed Army Inst Res, United States Mil HIV Res Program, Silver Spring, MD 20910 USA. [de Souza, Mark S.; Karasavvas, Nicos; Madnote, Sirinan; O'Connell, Robert] US Army Med Component, Armed Forces Res Inst Med Sci, United States Mil HIV Res Program, Bangkok, Thailand. [Sidney, John; Sette, Alessandro] La Jolla Inst Allergy & Immunol, La Jolla, CA 92037 USA. [Nitayaphan, Sorachai] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Pitisuttuthum, Punnee] Mahidol Univ, Fac Trop Med, Vaccine Trials Ctr, Bangkok 10400, Thailand. [Kaewkungwal, Jaranit] Mahidol Univ, Fac Trop Med, Ctr Excellence Biomed & Publ Hlth Informat, Bangkok 11000, Thailand. [Rerks-Ngarm, Supachai] Minist Publ Hlth, Dept Dis Control, Nonthaburi 11000, Thailand. [Marovich, Mary] NIH, Off AIDS Res, Bethesda, MD 20892 USA. RP Ratto-Kim, S (reprint author), Walter Reed Army Inst Res, United States Mil HIV Res Program, Silver Spring, MD 20910 USA. EM sratto-kim@hivresearch.org FU Henry M. Jackson Foundation [W81XWH-07-2-0067]; U.S. Department of Defense FX This work was funded by the cooperative agreement (W81XWH-07-2-0067) between the Henry M. Jackson Foundation for the Advancement of Military Medicine and the U.S. Department of Defense. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. The views expressed herein are those of the authors and should not be construed to represent the positions of the U.S. Army or Department of Defense. NR 16 TC 5 Z9 5 U1 0 U2 16 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD FEB 9 PY 2015 VL 10 IS 2 AR e0115582 DI 10.1371/journal.pone.0115582 PG 9 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA CA7UO UT WOS:000349123100004 PM 25665096 ER PT J AU Cao, Q Thawait, G Gang, GJ Zbijewski, W Reigel, T Brown, T Corner, B Demehri, S Siewerdsen, JH AF Cao, Qian Thawait, Gaurav Gang, Grace J. Zbijewski, Wojciech Reigel, Thomas Brown, Tyler Corner, Brian Demehri, Shadpour Siewerdsen, Jeffrey H. TI Characterization of 3D joint space morphology using an electrostatic model (with application to osteoarthritis) SO PHYSICS IN MEDICINE AND BIOLOGY LA English DT Article DE joint space; computed tomography; electrostatics; arthritis; modeling; knee; bone ID BEAM CT SYSTEM; OPTIMIZATION; EXTREMITY AB Joint space morphology can be indicative of the risk, presence, progression, and/or treatment response of disease or trauma. We describe a novel methodology of characterizing joint space morphology in high-resolution 3D images (e.g. cone-beam CT (CBCT)) using a model based on elementary electrostatics that overcomes a variety of basic limitations of existing 2D and 3D methods. The method models each surface of a joint as a conductor at fixed electrostatic potential and characterizes the intra-articular space in terms of the electric field lines resulting from the solution of Gauss' Law and the Laplace equation. As a test case, the method was applied to discrimination of healthy and osteoarthritic subjects (N = 39) in 3D images of the knee acquired on an extremity CBCT system. The method demonstrated improved diagnostic performance (area under the receiver operating characteristic curve, AUC > 0.98) compared to simpler methods of quantitative measurement and qualitative image-based assessment by three expert musculoskeletal radiologists (AUC = 0.87, p-value = 0.007). The method is applicable to simple (e.g. the knee or elbow) or multi-axial joints (e.g. the wrist or ankle) and may provide a useful means of quantitatively assessing a variety of joint pathologies. C1 [Cao, Qian; Gang, Grace J.; Zbijewski, Wojciech; Reigel, Thomas; Siewerdsen, Jeffrey H.] Johns Hopkins Univ, Dept Biomed Engn, Baltimore, MD 21218 USA. [Thawait, Gaurav; Demehri, Shadpour; Siewerdsen, Jeffrey H.] Johns Hopkins Univ, Russell H Morgan Dept Radiol, Baltimore, MD USA. [Brown, Tyler; Corner, Brian] US Army Natick Soldier Res, Ctr Dev & Engn, Natick, MA USA. RP Cao, Q (reprint author), Johns Hopkins Univ, Dept Biomed Engn, Baltimore, MD 21218 USA. EM jeff.siewerdsen@jhu.edu FU [NIH-R21-AR-062293] FX This research was supported by NIH-R21-AR-062293 and collaboration with the US Army Natick Soldier Research, Development, and Engineering Center. The authors thank Dr J Yorkston and Dr N Packard (Carestream Health) for their support on this project, Yifu Ding and Bisakha Ray (Department of Biomedical Engineering, Johns Hopkins University) for early investigation of the electrostatic model, and Sureerat Reaungamornrat (Department of Computer Science, Johns Hopkins University) for valuable discussion of image segmentation methods. Clinical studies were performed with assistance provided by Dr John Carrino (clinical expertise and image interpretation), Dr Mahadevappa Mahesh (medical physics radiation and image quality tests), Ms Shannon Comes, Ms Martha DeCarlo, Ms Paula Frank, Ms Janet McCormack, and Mr Anthony Petruccy (Russell H Morgan Department of Radiology, Johns Hopkins Hospital). NR 22 TC 6 Z9 6 U1 0 U2 1 PU IOP PUBLISHING LTD PI BRISTOL PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND SN 0031-9155 EI 1361-6560 J9 PHYS MED BIOL JI Phys. Med. Biol. PD FEB 7 PY 2015 VL 60 IS 3 BP 947 EP 960 DI 10.1088/0031-9155/60/3/947 PG 14 WC Engineering, Biomedical; Radiology, Nuclear Medicine & Medical Imaging SC Engineering; Radiology, Nuclear Medicine & Medical Imaging GA CB2EB UT WOS:000349438400007 PM 25575100 ER PT J AU Sherwin, JS Gaston, JR AF Sherwin, Jason Samuel Gaston, Jeremy Rodney TI Experience Does Not Equal Expertise in Recognizing Infrequent Incoming Gunfire: Neural Markers for Experience and Task Expertise at Peak Behavioral Performance SO PLOS ONE LA English DT Article ID PERCEPTUAL DECISION-MAKING; ELECTROMAGNETIC TOMOGRAPHY LORETA; BRAIN; FMRI; EEG; NEGATIVITY; ERP AB For a soldier, decisions to use force can happen rapidly and sometimes lead to undesired consequences. In many of these situations, there is a rapid assessment by the shooter that recognizes a threat and responds to it with return fire. But the neural processes underlying these rapid decisions are largely unknown, especially amongst those with extensive weapons experience and expertise. In this paper, we investigate differences in weapons experts and non-experts during an incoming gunfire detection task. Specifically, we analyzed the electroencephalography (EEG) of eleven expert marksmen/soldiers and eleven non-experts while they listened to an audio scene consisting of a sequence of incoming and non-incoming gunfire events. Subjects were tasked with identifying each event as quickly as possible and committing their choice via a motor response. Contrary to our hypothesis, experts did not have significantly better behavioral performance or faster response time than novices. Rather, novices indicated trends of better behavioral performance than experts. These group differences were more dramatic in the EEG correlates of incoming gunfire detection. Using machine learning, we found condition-discriminating EEG activity among novices showing greater magnitude and covering longer periods than those found in experts. We also compared group-level source reconstruction on the maximum discriminating neural correlates and found that each group uses different neural structures to perform the task. From condition-discriminating EEG and source localization, we found that experts perceive more categorical overlap between incoming and non-incoming gunfire. Consequently, the experts did not perform as well behaviorally as the novices. We explain these unexpected group differences as a consequence of experience with gunfire not being equivalent to expertise in recognizing incoming gunfire. C1 [Sherwin, Jason Samuel] Suny Downstate Med Ctr, Dept Ophthalmol, Brooklyn, NY 11203 USA. [Sherwin, Jason Samuel; Gaston, Jeremy Rodney] US Army Res Lab, Human Res & Engn Directorate, Aberdeen Proving Ground, MD USA. RP Sherwin, JS (reprint author), Suny Downstate Med Ctr, Dept Ophthalmol, Brooklyn, NY 11203 USA. EM jason.sherwin@downstate.edu FU U.S. Army Research Office [W911NF-11-1-0219]; U.S. Army Research Laboratory FX This work was supported by a grant from the U.S. Army Research Office (W911NF-11-1-0219) and in part by an appointment to the U.S. Army Research Laboratory Postdoctoral Fellowship Program administered by the Oak Ridge Associated Universities through a contract with the U.S. Army Research Laboratory. NR 31 TC 0 Z9 0 U1 0 U2 11 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD FEB 6 PY 2015 VL 10 IS 2 AR e0115629 DI 10.1371/journal.pone.0115629 PG 24 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA CB2GK UT WOS:000349444900026 PM 25658335 ER PT J AU Hammamieh, R Chakraborty, N Lin, YX Shupp, JW Miller, SA Morris, S Jett, M AF Hammamieh, Rasha Chakraborty, Nabarun Lin, Yixin Shupp, Jeffrey W. Miller, Stacy-Ann Morris, Sam Jett, Marti TI Characterization of the interaction of staphylococcal enterotoxin B with CD1d expressed in human renal proximal tubule epithelial cells SO BMC MICROBIOLOGY LA English DT Article ID T-CELLS; SUPERANTIGEN GENES; IMMUNE-SYSTEM; CUTTING EDGE; TOXIC-SHOCK; NKT CELLS; AUREUS; KIDNEY; IMMUNOASSAY; ACTIVATION AB Background: Participation of renal cells in the pathogenesis of staphylococcal enterotoxin B (SEB) is critical for late cleansing and sequestration of the antigens facilitated by CD1d mediated antigen sensing and recognition. This is a noted deviation from the typical antigen recognition process that recruits the major histocompatibility complex class II (MHC II) molecules. The immunological importance of CD1d is underscored by its influences on the performances of natural killer T-cells and thereby mediates the innate and adaptive immune systems. Results: Using diffraction-based dotReady (TM) immunoassays, the present study showed that SEB directly and specifically conjugated to CD1d. The specificity of the conjugation between SEB and CD1d expressed on human renal proximal tubule epithelial cells (RPTEC) was further established by selective inhibition of CD1d prior to its exposure to SEB. We found that SEB induced the expression of CD1d on the cell surface prompting a rapid conjugation between them. The mRNA transcripts encoding CD1d remained elevated potentially after completing the antigen cleansing process. Conclusion: Molecular targets associated with the delayed pathogenic response have essential therapeutic values. Particularly in the event of bioterrorism, the caregivers are typically able to intervene much later than the toxic exposures. Given circumstances mandate a paradigm shift from the conventional therapeutic strategy that counts on targeting the host markers responding to the early assault of pathogens. We demonstrated the role of CD1d in the late stage of pathogen recognition and cleansing, and thereby underscored its clinical potential in treating bioweaponizable antigens, such as Staphylococcal enterotoxin B (SEB). C1 [Hammamieh, Rasha; Chakraborty, Nabarun; Miller, Stacy-Ann; Jett, Marti] US Army, Ctr Environm Hlth Res Ft Detrick, Ft Detrick, MD 21702 USA. [Lin, Yixin; Morris, Sam] Axela Inc, Toronto, ON M9W 1B3, Canada. [Shupp, Jeffrey W.] Washington Hosp Ctr, Dept Surg, Burn Ctr, Washington, DC 20010 USA. RP Hammamieh, R (reprint author), US Army, Ctr Environm Hlth Res Ft Detrick, 568 Doughten Dr, Ft Detrick, MD 21702 USA. EM Rasha.Hammamieh1.civ@mail.mil FU DTRA: Host Factors [CB3293]; Shock-Inducing Bioagents FX Authors like to acknowledge the insightful contribution from the internal editor Dr. Julia Scheerer. RH, NC, SM and MJ like to acknowledge the funding from DTRA: CB3293-Host Factors and Shock-Inducing Bioagents. NR 60 TC 0 Z9 0 U1 0 U2 3 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1471-2180 J9 BMC MICROBIOL JI BMC Microbiol. PD FEB 4 PY 2015 VL 15 AR 12 DI 10.1186/s12866-015-0344-5 PG 10 WC Microbiology SC Microbiology GA CB0VW UT WOS:000349346800002 PM 25649790 ER PT J AU Rapp, PE Keyser, DO Albano, A Hernandez, R Gibson, DB Zambon, RA Hairston, WD Hughes, JD Krystal, A Nichols, AS AF Rapp, Paul E. Keyser, David O. Albano, Alfonso Hernandez, Rene Gibson, Douglas B. Zambon, Robert A. Hairston, W. David Hughes, John D. Krystal, Andrew Nichols, Andrew S. TI Traumatic brain injury detection using electrophysiological methods SO FRONTIERS IN HUMAN NEUROSCIENCE LA English DT Review DE event-related potentials; EEG; traumatic brain injury; gEEG; non-linear dynamical analysis ID CLOSED-HEAD-INJURY; EVENT-RELATED POTENTIALS; GRAPH-THEORETICAL ANALYSIS; TEST-RETEST RELIABILITY; SMALL-WORLD NETWORKS; ATTENTION-DEFICIT/HYPERACTIVITY DISORDER; INTRACLASS CORRELATION-COEFFICIENTS; MILD COGNITIVE IMPAIRMENT; MAJOR DEPRESSIVE DISORDER; AUDITORY ODDBALL TASK AB Measuring neuronal activity with electrophysiological methods may be useful in detecting neurological dysfunctions, such as mild traumatic brain injury (mTBI). This approach may be particularly valuable for rapid detection in at-risk populations including military service members and athletes. Electrophysiological methods, such as quantitative electroencephalography (gEEG) and recording event-related potentials (ERPs) may be promising; however, the field is nascent and significant controversy exists on the efficacy and accuracy of the approaches as diagnostic tools. For example, the specific measures derived from an electroencephalogram (EEG) that are most suitable as markers of dysfunction have not been clearly established. A study was conducted to summarize and evaluate the statistical rigor of evidence on the overall utility of gEEG as an mTBI detection tool. The analysis evaluated gEEG measures/parameters that may be most suitable as fieldable diagnostic tools, identified other types of EEG measures and analysis methods of promise, recommended specific measures and analysis methods for further development as mTBI detection tools, identified research gaps in the field, and recommended future research and development thrust areas. The gEEG study group formed the following conclusions: (1) Individual gEEG measures provide limited diagnostic utility for mTBI. However, many measures can be important features of gEEG discriminant functions, which do show significant promise as mTBI detection tools. (2) ERPs offer utility in mTBI detection. In fact, evidence indicates that ERPs can identify abnormalities in cases where EEGs alone are non-disclosing. (3)The standard mathematical procedures used in the characterization of mTBI EEGs should be expanded to incorporate newer methods of analysis including non-linear dynamical analysis, complexity measures, analysis of causal interactions, graph theory, and information dynamics. (4) Reports of high specificity in gEEG evaluations of TBI must be interpreted with care. High specificities have been reported in carefully constructed clinical studies in which healthy controls were compared against a carefully selected TBI population. The published literature indicates, however, that similar abnormalities in gEEG measures are observed in other neuropsychiatric disorders. While it may be possible to distinguish a clinical patient from a healthy control participant with this technology, these measures are unlikely to discriminate between, for example, major depressive disorder, bipolar disorder, or TBI. The specificities observed in these clinical studies may well be lost in real world clinical practice. (5)The absence of specificity does not preclude clinical utility. The possibility of use as a longitudinal measure of treatment response remains. However, efficacy as a longitudinal clinical measure does require acceptable test-retest reliability. To date, very few test retest reliability studies have been published with gEEG data obtained from TBI patients or from healthy controls. This is a particular concern because high variability is a known characteristic of the injured central nervous system. C1 [Rapp, Paul E.; Keyser, David O.] Uniformed Serv Univ Hlth Sci, Sch Med, Bethesda, MD 20814 USA. [Albano, Alfonso] Bryn Mawr Coll, Bryn Mawr, PA 19010 USA. [Hernandez, Rene] US Navy, Bur Med & Surg, Frederick, MD USA. [Gibson, Douglas B.] US Army, Res Inst, Ft Belvoir, VA USA. [Zambon, Robert A.; Nichols, Andrew S.] Booz Allen Hamilton Inc, Mclean, VA USA. [Hairston, W. David] US Army, Res Lab, Aberdeen, MD USA. [Hughes, John D.] Naval Med Res Ctr, Silver Spring, MD USA. [Krystal, Andrew] Duke Univ, Durham, NC USA. RP Keyser, DO (reprint author), Uniformed Serv Univ Hlth Sci, Dept Mil & Emergency Med, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA. EM david.keyser@usuhs.edu OI lechner, courtlen/0000-0001-8929-6407; Hairston, W. David/0000-0003-4432-8430 FU Combat Casualty Care Research Program (CCCRP) of the U.S. Army Medical Research & Materiel Command (USAMRMC); Traumatic Injury Research Program of the Uniformed Services University of the Health Sciences; Defense Medical Research and Development Program; United States Marine Corps Systems Command FX The opinions and assertions contained herein are the private opinions of the authors and are not to be construed as official or reflecting the views of the United Sates Navy, Department of Defense nor the US Government. This research effort was supported by the Combat Casualty Care Research Program (CCCRP) of the U.S. Army Medical Research & Materiel Command (USAMRMC). Paul E. Rapp and David O. Keyser would like to acknowledge support from the Traumatic Injury Research Program of the Uniformed Services University of the Health Sciences, from the Defense Medical Research and Development Program and from the United States Marine Corps Systems Command. Drs. John D. Hughes and Rene Hernandez are military service members. This work was prepared as part of their official duties. Title 17 U.S.C. 105 provides that "Copyright protection under this title is not available for any work of the United States Government." Title 17 U.S.C. 101 defines a U.S. Government work as a work prepared by a military service member or employee of the U.S. Government as part of that person's official duties. NR 397 TC 8 Z9 9 U1 4 U2 29 PU FRONTIERS MEDIA SA PI LAUSANNE PA PO BOX 110, EPFL INNOVATION PARK, BUILDING I, LAUSANNE, 1015, SWITZERLAND SN 1662-5161 J9 FRONT HUM NEUROSCI JI Front. Hum. Neurosci. PD FEB 4 PY 2015 VL 9 AR 11 DI 10.3389/fnhum.2015.00011 PG 32 WC Neurosciences; Psychology SC Neurosciences & Neurology; Psychology GA CA4ZX UT WOS:000348917700001 PM 25698950 ER PT J AU Li, XY Deng, ZQD Brown, RS Fu, T Martinez, JJ McMichael, GA Skalski, JR Townsend, RL Trumbo, BA Ahmann, ML Renholds, JF AF Li, Xinya Deng, Zhiqun D. Brown, Richard S. Fu, Tao Martinez, Jayson J. McMichael, Geoffrey A. Skalski, John R. Townsend, Richard L. Trumbo, Bradly A. Ahmann, Martin L. Renholds, Jon F. TI Migration depth and residence time of juvenile salmonids in the forebays of hydropower dams prior to passage through turbines or juvenile bypass systems: implications for turbine-passage survival SO CONSERVATION PHYSIOLOGY LA English DT Article DE Acclimation depth; acoustic telemetry; juvenile salmonid; migration depth; three-dimensional tracking; turbine passage ID ACOUSTIC TELEMETRY SYSTEM; DIEL VERTICAL MIGRATION; HYDROTURBINE PASSAGE; ANTIPREDATION WINDOW; SOCKEYE-SALMON; INSTRUMENTATION; BAROTRAUMA; TRACKING; DESIGN AB Little is known about the three-dimensional depth distributions in rivers of individually marked fish that are in close proximity to hydropower facilities. Knowledge of the depth distributions of fish approaching dams can be used to understand how vulnerable fish are to injuries such as barotrauma as they pass through dams. To predict the possibility of barotrauma injury caused by pressure changes during turbine passage, it is necessary to understand fish behaviour relative to acclimation depth in dam forebays as they approach turbines. A guiding study was conducted using high-resolution three-dimensional tracking results of salmonids implanted with Juvenile Salmon Acoustic Telemetry System transmitters to investigate the depth distributions of subyearling and yearling Chinook salmon (Oncorhynchus tshawytscha) and juvenile steelhead (Oncorhynchus mykiss) passing two dams on the Snake River in Washington State. Multiple approaches were evaluated to describe the depth at which fish were acclimated, and statistical analyses were performed on large data sets extracted from similar to 28 000 individually tagged fish during 2012 and 2013. Our study identified patterns of depth distributions of juvenile salmonids in forebays prior to passage through turbines or juvenile bypass systems. This research indicates that the median depth at which juvenile salmonids approached turbines ranged from 2.8 to 12.2 m, with the depths varying by species/life history, year, location (which dam) and diel period (between day and night). One of the most enlightening findings was the difference in dam passage associated with the diel period. The amount of time that turbine-passed fish spent in the immediate forebay prior to entering the powerhouse was much lower during the night than during the day. This research will allow scientists to understand turbine-passage survival better and enable them to assess more accurately the effects of dam passage on juvenile salmon survival. C1 [Li, Xinya; Deng, Zhiqun D.; Fu, Tao; Martinez, Jayson J.] Pacific NW Natl Lab, Hydrol Grp, 3320 Innovat Blvd,POB 999,MSIN K9-33, Richland, WA 99352 USA. [Brown, Richard S.; McMichael, Geoffrey A.] Pacific NW Natl Lab, Ecol Grp, Richland, WA 99352 USA. [Skalski, John R.; Townsend, Richard L.] Univ Washington, Sch Aquat & Fishery Sci, Seattle, WA 98101 USA. [Trumbo, Bradly A.; Ahmann, Martin L.; Renholds, Jon F.] US Army Corps Engineers, Walla Walla, WA 99362 USA. RP Deng, ZQD (reprint author), Pacific NW Natl Lab, Hydrol Grp, 3320 Innovat Blvd,POB 999,MSIN K9-33, Richland, WA 99352 USA. EM zhiqun.deng@pnnl.gov RI Deng, Daniel/A-9536-2011 OI Deng, Daniel/0000-0002-8300-8766 FU US Army Corps of Engineers, Walla Walla District FX This work was supported by the US Army Corps of Engineers, Walla Walla District. NR 33 TC 0 Z9 0 U1 10 U2 13 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 2051-1434 J9 CONSERV PHYSIOL JI Conserv. Physiol. PD FEB 3 PY 2015 VL 3 AR cou064 DI 10.1093/conphys/cou064 PG 17 WC Biodiversity Conservation; Ecology; Environmental Sciences; Physiology SC Biodiversity & Conservation; Environmental Sciences & Ecology; Physiology GA DK8QV UT WOS:000375194200001 PM 27293685 ER PT J AU Welkos, S Bozue, J Twenhafel, N Cote, C AF Welkos, Susan Bozue, Joel Twenhafel, Nancy Cote, Christopher TI Animal Models for the Pathogenesis, Treatment, and Prevention of Infection by Bacillus anthracis SO MICROBIOLOGY SPECTRUM LA English DT Article ID EXPERIMENTAL INHALATION ANTHRAX; RECOMBINANT PROTECTIVE ANTIGEN; AEROSOL CHALLENGE MODEL; EXPERIMENTAL RESPIRATORY ANTHRAX; HUMAN MONOCLONAL-ANTIBODY; LETHAL FACTOR COMPONENTS; IIA PHOSPHOLIPASE A(2); ZEALAND WHITE-RABBITS; AFRICAN-GREEN MONKEY; AMES STRAIN SPORES AB This article reviews the characteristics of the major animal models utilized for studies on Bacillus anthracis and highlights their contributions to understanding the pathogenesis and host responses to anthrax and its treatment and prevention. Advantages and drawbacks associated with each model, to include the major models (murine, guinea pig, rabbit, nonhuman primate, and rat), and other less frequently utilized models, are discussed. Although the three principal forms of anthrax are addressed, the main focus of this review is on models for inhalational anthrax. The selection of an animal model for study is often not straightforward and is dependent on the specific aims of the research or test. No single animal species provides complete equivalence to humans; however, each species, when used appropriately, can contribute to a more complete understanding of anthrax and its etiologic agent. C1 [Welkos, Susan; Bozue, Joel; Cote, Christopher] US Army Med Res Inst Infect Dis, Bacteriol Div, Frederick, MD 21702 USA. [Twenhafel, Nancy] US Army Med Res Inst Infect Dis, Pathol Div, Frederick, MD 21702 USA. RP Welkos, S (reprint author), US Army Med Res Inst Infect Dis, Bacteriol Div, Frederick, MD 21702 USA. EM susan.welkos@us.army.mil NR 389 TC 0 Z9 0 U1 2 U2 3 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA EI 2165-0497 J9 MICROBIOL SPECTR JI Microbiol. Spectr. PD FEB PY 2015 VL 3 IS 1 AR TBS-0001-2012 DI 10.1128/microbiolspec.TBS-0001-2012 PG 38 WC Microbiology SC Microbiology GA CU2DI UT WOS:000363332500017 PM 26104551 ER PT J AU Hubbard, K Beske, P Lyman, M McNutt, P AF Hubbard, Kyle Beske, Phillip Lyman, Megan McNutt, Patrick TI Functional Evaluation of Biological Neurotoxins in Networked Cultures of Stem Cell-derived Central Nervous System Neurons SO JOVE-JOURNAL OF VISUALIZED EXPERIMENTS LA English DT Article DE Neuroscience; Issue 96; embryonic stem cells; stem cell-derived neurons; botulinum neurotoxin detection; electrophysiology; synapse; neuronal networks; glutamatergic synapse; GABAergic synapse ID BOTULINUM NEUROTOXIN; NEUROMUSCULAR-JUNCTION; IN-VIVO; DERIVATION; IDENTIFICATION; MOUSE AB Therapeutic and mechanistic studies of the presynaptically targeted clostridial neurotoxins (CNTs) have been limited by the need for a scalable, cell-based model that produces functioning synapses and undergoes physiological responses to intoxication. Here we describe a simple and robust method to efficiently differentiate murine embryonic stem cells (ESCs) into defined lineages of synaptically active, networked neurons. Following an 8 day differentiation protocol, mouse embryonic stem cell-derived neurons (ESNs) rapidly express and compartmentalize neurotypic proteins, form neuronal morphologies and develop intrinsic electrical responses. By 18 days after differentiation (DIV 18), ESNs exhibit active glutamatergic and gamma-aminobutyric acid (GABA)ergic synapses and emergent network behaviors characterized by an excitatory: inhibitory balance. To determine whether intoxication with CNTs functionally antagonizes synaptic neurotransmission, thereby replicating the in vivo pathophysiology that is responsible for clinical manifestations of botulism or tetanus, whole-cell patch clamp electrophysiology was used to quantify spontaneous miniature excitatory post-synaptic currents (mEPSCs) in ESNs exposed to tetanus neurotoxin (TeNT) or botulinum neurotoxin (BoNT) serotypes / A-/G. In all cases, ESNs exhibited near-complete loss of synaptic activity within 20 hr. Intoxicated neurons remained viable, as demonstrated by unchanged resting membrane potentials and intrinsic electrical responses. To further characterize the sensitivity of this approach, dose-dependent effects of intoxication on synaptic activity were measured 20 hr after addition of BoNT/A. Intoxication with 0.005 mu M BoNT/A resulted in a significant decrement in mEPSCs, with a median inhibitory concentration (IC50) of 0.013 mu M. Comparisons of median doses indicate that functional measurements of synaptic inhibition are faster, more specific and more sensitive than SNARE cleavage assays or the mouse lethality assay. These data validate the use of synaptically coupled, stem cell-derived neurons for the highly specific and sensitive detection of CNTs. C1 [Hubbard, Kyle; Beske, Phillip; Lyman, Megan; McNutt, Patrick] US Army, Med Res Inst Chem Def, Div Res, Cellular Mol Biol Branch, Aberdeen Proving Ground, MD 21010 USA. RP Hubbard, K (reprint author), US Army, Med Res Inst Chem Def, Div Res, Cellular Mol Biol Branch, Aberdeen Proving Ground, MD 21010 USA. EM kyle.s.hubbard.ctr@mail.mil OI McNutt, Patrick/0000-0002-5703-4565 FU National Institutes of Health National Institute of Allergy and Infectious Diseases [AOD12058-0001-0000]; Defense Threat Reduction Agency - Joint Science and Technology Office, Medical ST Division [CBM.THRTOX.01.10.RC.023, CBM.THRTOX.01.RC.014] FX This work was funded by the National Institutes of Health National Institute of Allergy and Infectious Diseases (IAA number AOD12058-0001-0000) and the Defense Threat Reduction Agency - Joint Science and Technology Office, Medical S&T Division (grant numbers CBM.THRTOX.01.10.RC.023 and CBM.THRTOX.01.RC.014). This research was performed while P.B. held a Defense Threat Reduction Agency-National Research Council Research Associateship Award and K.H. held a National Research Council Research Associateship Award. We thank Angela Adkins and Kaylie Tuznik (USAMRICD) for technical assistance; and Cindy Kronman (USAMRICD) for editorial assistance. The views expressed in this article are those of the authors and do not reflect the official policy of the Department of Army, Department of Defense, or the U.S. Government. NR 20 TC 0 Z9 0 U1 0 U2 1 PU JOURNAL OF VISUALIZED EXPERIMENTS PI CAMBRIDGE PA 1 ALEWIFE CENTER, STE 200, CAMBRIDGE, MA 02140 USA SN 1940-087X J9 JOVE-J VIS EXP JI J. Vis. Exp. PD FEB PY 2015 IS 96 AR e52361 DI 10.3791/52361 PG 10 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA CR7MH UT WOS:000361533700028 ER PT J AU Muniz, A Ramesh, KR Greene, WA Choi, JH Wang, HC AF Muniz, Alberto Ramesh, Kaini R. Greene, Whitney A. Choi, Jae-Hyek Wang, Heuy-Ching TI Deriving Retinal Pigment Epithelium (RPE) from Induced Pluripotent Stem (iPS) Cells by Different Sizes of Embryoid Bodies SO JOVE-JOURNAL OF VISUALIZED EXPERIMENTS LA English DT Article DE Stem Cell Biology; Issue 96; Induced pluripotent stem (iPS) cells; retinal pigment epithelium (RPE); retinal pigment epithelium derived from induced pluripotent stem (iPS-RPE) cells; tissue engineering; embryoid bodies (EBs) ID HUMAN BLASTOCYSTS; IN-VITRO; LINES AB Pluripotent stem cells possess the ability to proliferate indefinitely and to differentiate into almost any cell type. Additionally, the development of techniques to reprogram somatic cells into induced pluripotent stem (iPS) cells has generated interest and excitement towards the possibility of customized personal regenerative medicine. However, the efficiency of stem cell differentiation towards a desired lineage remains low. The purpose of this study is to describe a protocol to derive retinal pigment epithelium (RPE) from iPS cells (iPS-RPE) by applying a tissue engineering approach to generate homogenous populations of embryoid bodies (EBs), a common intermediate during in vitro differentiation. The protocol applies the formation of specific size of EBs using microwell plate technology. The methods for identifying protein and gene markers of RPE by immunocytochemistry and reverse-transcription polymerase chain reaction (RT-PCR) are also explained. Finally, the efficiency of differentiation in different sizes of EBs monitored by fluorescence-activated cell sorting (FACS) analysis of RPE markers is described. These techniques will facilitate the differentiation of iPS cells into RPE for future applications. C1 [Muniz, Alberto; Ramesh, Kaini R.; Greene, Whitney A.; Choi, Jae-Hyek; Wang, Heuy-Ching] US Army Inst Surg Res, Ocular Trauma, Ft Sam Houston, TX 78234 USA. RP Wang, HC (reprint author), US Army Inst Surg Res, Ocular Trauma, Ft Sam Houston, TX 78234 USA. EM heuy-ching.h.wang.civ@mail.mil FU U.S. Army Clinical Rehabilitative Medicine Research Program (CRMRP); Military Operational Medicine Research Program (MOMRP) FX The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the Department of the Army or the Department of Defense. This research was performed while the authors Alberto Muniz, Ramesh R Kaini, Whitney A Greene and Jae-Hyek Choi held a National Research Council Postdoctoral Research Associateship at the USAISR. This work was supported by U.S. Army Clinical Rehabilitative Medicine Research Program (CRMRP) and Military Operational Medicine Research Program (MOMRP). NR 23 TC 0 Z9 0 U1 0 U2 1 PU JOURNAL OF VISUALIZED EXPERIMENTS PI CAMBRIDGE PA 1 ALEWIFE CENTER, STE 200, CAMBRIDGE, MA 02140 USA SN 1940-087X J9 JOVE-J VIS EXP JI J. Vis. Exp. PD FEB PY 2015 IS 96 AR e52262 DI 10.3791/52262 PG 10 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA CR7MH UT WOS:000361533700018 ER PT J AU Wu, JC Rose, LF Christy, RJ Leung, KP Chan, RK AF Wu, Jesse C. Rose, Lloyd F. Christy, Robert J. Leung, Kai P. Chan, Rodney K. TI Full-Thickness Thermal Injury Delays Wound Closure in a Murine Model SO ADVANCES IN WOUND CARE LA English DT Article ID CIRCULATING ANGIOGENIC CELLS; GROWTH-FACTOR; ISCHEMIA-REPERFUSION; DIABETIC MOUSE; MICE; FIBROBLASTS; BURNS; CONTRACTION; MOBILIZATION; SCAFFOLDS AB Objective: The contemporary treatment of a full-thickness burn consists of early eschar excision followed by immediate closure of the open wound using autologous skin. However, most animal models study burn wound healing with the persistence of the burn eschar. Our goal is to characterize a murine model of burn eschar excision to study wound closure kinetics. Approach: C57BL/6 male mice were divided into three groups: contact burn, scald burn, or unburned control. Mice were burned at 80 degrees C for 5, 10, or 20 s. After 2 days, the eschar was excised and wound closure was documented until postexcision day 13. Biopsies were examined for structural morphology and a-smooth muscle actin. In a subsequent interval-excision experiment (80 degrees C scald for 10 s), the burn eschar was excised after 5 or 10 days postburn to determine the effect of a prolonged inflammatory focus. Results: Histology of both contact and scald burns revealed characteristics of a full-thickness injury marked by collagen coagulation and tissue necrosis. Excision at 2 days after a 20-s burn from either scald or contact showed significant delay in wound closure. Interval excision of the eschar, 5 or 10 days postburn, also showed significant delay in wound closure. Both interval-excision groups showed prolonged inflammation and increased myofibroblasts. Innovation and Conclusions: We have described the kinetics of wound closure in a murine model of a full-thickness burn excision. Both contact and scald full-thickness burn resulted in significantly delayed wound closure. In addition, prolonged interval-excision of the eschar appeared to increase and prolong inflammation. C1 [Wu, Jesse C.; Rose, Lloyd F.; Leung, Kai P.; Chan, Rodney K.] US Army Inst Surg Res, Dent & Trauma Res Detachment, Ft Sam Houston, TX USA. [Wu, Jesse C.; Rose, Lloyd F.; Christy, Robert J.; Leung, Kai P.; Chan, Rodney K.] US Army Inst Surg Res, Ft Sam Houston, TX USA. RP Wu, JC (reprint author), US Army Inst Surg Res, Dent & Trauma Res Detachment, 3650 Chambers Pass, Jbsa Ft Sam Houston, TX 78234 USA. EM jesse.c.wu.ctr@mail.mil NR 35 TC 2 Z9 2 U1 0 U2 1 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 2162-1918 EI 2162-1934 J9 ADV WOUND CARE JI Adv. Wound Care PD FEB PY 2015 VL 4 IS 2 BP 83 EP 91 DI 10.1089/wound.2014.0570 PG 9 WC Dermatology SC Dermatology GA CL8XP UT WOS:000357257800002 ER PT J AU Plackett, TP Lynn, DC Zagol, BR Malone, BA Detro, JF Seery, JM Deveaux, PG Sawyer, EM Ellison, RW AF Plackett, Timothy P. Lynn, David C. Zagol, Bradley R. Malone, Bryan A. Detro, John F. Seery, Jason M. Deveaux, Peter G. Sawyer, Elizabeth M. Ellison, Richard W. TI Isolated Perivesicular Hematoma After Military Parachuting SO AEROSPACE MEDICINE AND HUMAN PERFORMANCE LA English DT Article DE military; occupational health; parachuting; hematoma; injury; urinary bladder ID URBAN COWBOY SYNDROME; INJURIES AB BACKGROUND: Isolated perivesicular hematomas are uncommonly described and not an injury typically reported in the literature after parachuting or skydiving. CASE REPORT: Herein, we described a series of three patients with isolated perivesicular hematomas sustained after military parachuting. All three patients were managed nonoperatively after a somewhat prolonged hospital course. Despite the lack of orthopedic injuries, all required physical therapy consultation and required an assisting device to aide with ambulation at the time of discharge. For all three individuals, follow-up imaging months after the injury demonstrated a continued presence of the hematoma. Clinically, the patients continued to have ambulatory and urological difficulties for several months after their injury. DISCUSSION: This injury pattern is uncommonly reported in the literature. An appropriate index of suspicion must be maintained or there may be a delay in diagnosis. Management of these injuries requires coordinated care between the trauma service, urology, and physical therapy. C1 Womack Army Med Ctr, Forward Surg Team 240, Ft Bragg, NC USA. Univ Louisville, Louisville, KY 40292 USA. RP Plackett, TP (reprint author), Loyola Univ, Med Ctr, Dept Surg, 2160 S First Ave, Maywood, IL 60153 USA. EM tplacke78@gmail.com NR 15 TC 0 Z9 0 U1 1 U2 1 PU AEROSPACE MEDICAL ASSOC PI ALEXANDRIA PA 320 S HENRY ST, ALEXANDRIA, VA 22314-3579 USA SN 2375-6314 EI 2375-6322 J9 AEROSP MED HUM PERF JI Aerosp. Med.Hum. Perform. PD FEB PY 2015 VL 86 IS 2 BP 136 EP 139 DI 10.3357/AMHP.4146.2015 PG 4 WC Biophysics; Public, Environmental & Occupational Health; Medicine, Research & Experimental SC Biophysics; Public, Environmental & Occupational Health; Research & Experimental Medicine GA CM0AG UT WOS:000357340000011 PM 25946739 ER PT J AU Sund, CJ Liu, SC Germane, KL Servinsky, MD Gerlach, ES Hurley, MM AF Sund, Christian J. Liu, Sanchao Germane, Katherine L. Servinsky, Matthew D. Gerlach, Elliot S. Hurley, Margaret M. TI Phosphoketolase flux in Clostridium acetobutylicum during growth on L-arabinose SO MICROBIOLOGY-SGM LA English DT Article ID GENOME-SCALE MODEL; METABOLIC NETWORK; TRANSCRIPTIONAL REGULATION; ALCOHOL FERMENTATION; ELECTRON FLOW; IN-SILICO; PATHWAY; CULTURE; SYSTEMS; SOLVENTOGENESIS AB Clostridium acetobutylicum's metabolic pathways have been studied for decades due to its metabolic diversity and industrial value, yet many details of its metabolism continue to emerge. The flux through the recently discovered pentose phosphoketolase pathway (PKP) in C. acetobutylicum has been determined for growth on xylose but transcriptional analysis indicated the pathway may have a greater contribution to arabinose metabolism. To elucidate the role of xylulose-5-phosphate/fructose-6-phosphate phosphoketolase (XFP), and the PKP in C. acetobutylicum, experimental and computational metabolic isotope analyses were performed under growth conditions of glucose or varying concentrations of xylose and arabinose. A positional bias in labelling between carbons 2 and 4 of butyrate was found and posited to be due to an enzyme isotope effect of the thiolase enzyme. A correction for the positional bias was applied, which resulted in reduction of residual error. Comparisons between model solutions with low residual error indicated flux through each of the two XFP reactions was variable, while the combined flux of the reactions remained relatively constant. PKP utilization increased with increasing xylose concentration and this trend was further pronounced during growth on arabinose. Mutation of the gene encoding XFP almost completely abolished flux through the PKP during growth on arabinose and resulted in decreased acetate/butyrate ratios. Greater flux through the PKP during growth on arabinose when compared with xylose indicated the pathway's primary role in C. acetobutylicum is arabinose metabolism. C1 [Sund, Christian J.; Servinsky, Matthew D.] US Army Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA. [Liu, Sanchao; Gerlach, Elliot S.] Fed Staffing Resources, Annapolis, MD 21401 USA. [Germane, Katherine L.] Oak Ridge Associated Univ, Belcamp, MD 21017 USA. [Hurley, Margaret M.] US Army Res Lab, RDRL WML B, Aberdeen Proving Ground, MD 21005 USA. RP Hurley, MM (reprint author), US Army Res Lab, RDRL WML B, 4600 Deer Creek Loop, Aberdeen Proving Ground, MD 21005 USA. EM margaret.m.hurley.civ@mail.mil NR 44 TC 2 Z9 2 U1 2 U2 9 PU SOC GENERAL MICROBIOLOGY PI READING PA MARLBOROUGH HOUSE, BASINGSTOKE RD, SPENCERS WOODS, READING RG7 1AG, BERKS, ENGLAND SN 1350-0872 J9 MICROBIOL-SGM JI Microbiology-(UK) PD FEB PY 2015 VL 161 BP 430 EP 440 DI 10.1099/mic.0.00008 PN 2 PG 11 WC Microbiology SC Microbiology GA CL0QR UT WOS:000356647800019 PM 25481877 ER PT J AU Kang, BH Racicot, K Pilkenton, SJ Kwon, YI Apostolidis, E AF Kang, Bou-Hee Racicot, Kenneth Pilkenton, Sarah J. Kwon, Young-In Apostolidis, Emmanouil TI Blueberry extract inhibits carbohydrate-hydrolyzing enzymes and these inhibitory activities are not proanthocyanidin dependent SO JOURNAL OF THE KOREAN SOCIETY FOR APPLIED BIOLOGICAL CHEMISTRY LA English DT Article DE Alpha-glucosidase inhibition; Blueberry; Maltase inhibition; Proanthocyanidins; Sucrase inhibition ID ANTIOXIDANT CAPACITY; CANCER CELLS; IN-VITRO; QUANTIFICATION; HYPERTENSION; MANAGEMENT; PATHWAY; GROWTH; RED AB This study investigates the carbohydrate-hydrolyzing inhibitory potential of blueberry extract on carbohydrate-hydrolyzing enzymes and evaluates if the inhibitory activity is proanthocyanidin (PAC) or lower molecular weight phenolic dependent. Freeze-dried blueberry powder was extracted using acetone and subjected to C-18 extraction (BAE). Low-molecular weight phenolics (BAE-LMW) and PACs (BAE-PAC) were separated from BAE with gel filtration chromatography using LH-20 column. Total phenolic content, PAC content, and phenolic profiles using HPLC, as well as rat a-glucosidase, sucrase, and maltase inhibitory activities, were determined for all samples. The rat alpha-glucosidase inhibitory activity of BAE (IC50 0.390 mg/mL TP basis) was enhanced in BAELMW (IC50 0.242 mg/mL TP basis) and reduced in BAEPAC (IC50 0.915 mg/mL TP basis). Similar trends were observed with maltase and sucrase inhibitory activities. Our findings suggest that blueberry acetone extract has inhibitory activity on carbohydrate-hydrolyzing enzymes and this effect is dependent on LMWs rather than PAC. C1 [Kang, Bou-Hee; Pilkenton, Sarah J.; Apostolidis, Emmanouil] Framingham State Univ, Dept Chem & Food Sci, Framingham, MA 01702 USA. [Racicot, Kenneth] US Army, Natick Soldier Res Engn Ctr, Natick, MA 01760 USA. [Kwon, Young-In] Hannam Univ, Dept Food & Nutr, Taejon, South Korea. RP Apostolidis, E (reprint author), Framingham State Univ, Dept Chem & Food Sci, Framingham, MA 01702 USA. EM bouheekang@gmail.com; kenneth.racicot.civ@mail.mil; spilkenton@framingham.edu; youngk@hnu.kr; eapostolidis@framingham.edu FU 6.2 Applied Research project area "Technologies for Nutrient/Novel Delivery Systems'' from the NSRDEC Combat Feeding Directorate FX This research was funded by the 6.2 Applied Research project area "Technologies for Nutrient/Novel Delivery Systems'' from the NSRDEC Combat Feeding Directorate. NR 25 TC 1 Z9 1 U1 7 U2 17 PU KOREAN SOC APPLIED BIOLOGICAL CHEMISTRY PI KANGNAM-GU PA RM 803, KOREA SCIENCE & TECHNOLOGY CENTER, 635-4 YEOGSAM-DONG, KANGNAM-GU, SEOUL 135-703, SOUTH KOREA SN 1738-2203 EI 2234-344X J9 J KOREAN SOC APPL BI JI J. Korean Soc. Appl. Biol. Chem. PD FEB PY 2015 VL 58 IS 1 BP 127 EP 136 DI 10.1007/s13765-015-0001-6 PG 10 WC Food Science & Technology SC Food Science & Technology GA CH9KO UT WOS:000354354700018 ER PT J AU Krakauer, T AF Krakauer, Teresa TI Sulfasalazine Attenuates Staphylococcal Enterotoxin B-Induced Immune Responses SO TOXINS LA English DT Article ID TOXIC-SHOCK-SYNDROME; FACTOR-KAPPA-B; HUMAN T-CELLS; MONONUCLEAR-CELLS; SUPERANTIGENS; RELEASE; CYTOKINES; TISSUE; BLOOD AB Staphylococcal enterotoxin B (SEB) and related exotoxins are important virulence factors produced by Staphylococcus aureus as they cause human diseases such as food poisoning and toxic shock. These toxins bind directly to cells of the immune system resulting in hyperactivation of both T lymphocytes and monocytes/macrophages. The excessive release of proinflammatory cytokines from these cells mediates the toxic effects of SEB. This study examined the inhibitory activities of an anti-inflammatory drug, sulfasalazine, on SEB-stimulated human peripheral blood mononuclear cells (PBMC). Sulfasalazine dose-dependently inhibited tumor necrosis factor alpha, interleukin 1 (IL-1) beta, IL-2, IL-6, interferon gamma (IFN gamma), and various chemotactic cytokines from SEB-stimulated human PBMC. Sulfasalazine also potently blocked SEB-induced T cell proliferation and NF kappa B activation. These results suggest that sulfasalazine might be useful in mitigating the toxic effects of SEB by blocking SEB-induced host inflammatory cascade and signaling pathways. C1 US Army, Dept Immunol, Mol Translat Sci Div, Med Res Inst Infect Dis, Frederick, MD 21702 USA. RP Krakauer, T (reprint author), US Army, Dept Immunol, Mol Translat Sci Div, Med Res Inst Infect Dis, Frederick, MD 21702 USA. EM Teresa.krakauer@us.army.mil FU DTRA under USAMRIID [1321180] FX This research was funded by DTRA under USAMRIID project number 1321180. Opinions, interpretations, conclusions, and recommendations are those of the author and are not necessarily endorsed by the U.S. Army. NR 24 TC 2 Z9 2 U1 2 U2 4 PU MDPI AG PI BASEL PA POSTFACH, CH-4005 BASEL, SWITZERLAND SN 2072-6651 J9 TOXINS JI Toxins PD FEB PY 2015 VL 7 IS 2 BP 553 EP 559 DI 10.3390/toxins7020553 PG 7 WC Toxicology SC Toxicology GA CH3YP UT WOS:000353967500020 PM 25688664 ER PT J AU Fadel, TR Steevens, JA Thomas, TA Linkov, I AF Fadel, Tarek R. Steevens, Jeffery A. Thomas, Treye A. Linkov, Igor TI The challenges of nanotechnology risk management SO NANO TODAY LA English DT Article DE Risk management; Risk assessment; Decision analysis; Policy; Nanomaterials; Regulations AB Recent developments in the design of advanced materials have furthered interest in the commercialization of new technologies. Central to this rapid technology revolution is the consideration of the potential environmental, health, and safety (EHS) risks associated with nanomaterials. Risk assessment has been proposed as a primary method to evaluate EHS risk and decision making, where risk assessment practitioners seek to understand what can go wrong, its likelihood of occurrence, and the ultimate consequences if it should arise. Here, we outlined recent efforts geared toward risk assessment for nanotechnologies and nanomaterials, and discuss the challenges associated with providing accurate risk information to policymakers and regulators. Risk assessment that includes analytical approaches will provide decision makers with adaptive guidance regarding how to balance risks with technological benefits and costs, communicate those trade-offs, and change nanomaterial design toward sustainable nanotechnology. Published by Elsevier Ltd. C1 [Fadel, Tarek R.] ITRI Inc, Linthicum, MD USA. [Steevens, Jeffery A.; Linkov, Igor] US Army, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. [Thomas, Treye A.] Consumer Prod Safety Commiss, Bethesda, MD USA. RP Linkov, I (reprint author), US Army, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. EM Igor.Linkov@usace.army.mil OI Fadel, Tarek/0000-0002-8416-5157 NR 13 TC 8 Z9 9 U1 2 U2 22 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1748-0132 EI 1878-044X J9 NANO TODAY JI Nano Today PD FEB PY 2015 VL 10 IS 1 BP 6 EP 10 DI 10.1016/j.nantod.2014.09.008 PG 5 WC Chemistry, Multidisciplinary; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary SC Chemistry; Science & Technology - Other Topics; Materials Science GA CH2PK UT WOS:000353866900005 ER PT J AU Kraemer, WJ Gordon, SE Fragala, MS Bush, JA Szivak, TK Flanagan, SD Hooper, DR Looney, DP Triplett, NT DuPont, WH Dziados, JE Marchitelli, LJ Patton, JF AF Kraemer, William J. Gordon, Scott E. Fragala, Maren S. Bush, Jill A. Szivak, Tunde K. Flanagan, Shawn D. Hooper, David R. Looney, David P. Triplett, N. Travis DuPont, Wiliam H. Dziados, Joseph E. Marchitelli, Louis J. Patton, John F. TI The effects of exercise training programs on plasma concentrations of proenkephalin Peptide F and catecholamines SO PEPTIDES LA English DT Article DE Proenkephalins; Opioid peptides; Epinephrine; Norepinephrine; Resistance training; Endurance training ID ADRENAL-MEDULLA; OPIOID PEPTIDE; ENKEPHALIN; RESPONSES; CELLS; RELEASE; SECRETION; STORAGE; BLOOD AB To determine if exercise training alters the pattern and magnitude of plasma concentrations of proenkephalin Peptide F and epinephrine, plasma proenkephalin [107-140] Peptide F-ir and cate-cholamines were examined pre-training (T-1), and after 4-(T-2), 8-(T-3), and 12-weeks (T-4) of training. 26 healthy men were matched and randomly assigned to one of three groups: heavy resistance strength training (Strength, n = 9), high intensity endurance training (Endurance, n = 8), or both training modalities combined (Combined, n = 9). Blood was collected using a syringe with a cannula inserted into a superficial arm vein with samples collected at rest, after each 7 min stage and 5 and 15 min into recovery. With training, all groups observed shifted plasma Peptide F responses to graded exercise, where significant increases were observed at lower exercise intensities. Increases in plasma epinephrine with exercise were observed in all groups. The Combined group saw increases at 25% at T-3 and for 50% at T-2, T-3, and T-4 which was higher than T-1. The Endurance group demonstrated increases for 50% at T-1, T-2, T-3 but not at T-4. The plasma epinephrine response to graded exercise was reduced in the Strength group. Increases in plasma norepinephrine above rest were observed starting at 50%. The Strength group demonstrated a significant reduction in norepinephrine observed at 100% at T-3 and T-4. Peptide F and catecholamines responses to graded exercise can be altered by different types of physical exercise training. Simultaneous high intensity training may produce adrenal medulla exhaustion when compared to single mode training. (C) 2015 Elsevier Inc. All rights reserved. C1 [Kraemer, William J.; Szivak, Tunde K.; Flanagan, Shawn D.; Hooper, David R.; DuPont, Wiliam H.] Ohio State Univ, Dept Human Sci, Columbus, OH 43210 USA. [Gordon, Scott E.] Univ N Carolina, Dept Kinesiol, Charlotte, NC 28223 USA. [Dziados, Joseph E.; Marchitelli, Louis J.; Patton, John F.] US Army, Environm Med Res Inst, Exercise Physiol Div, Natick, MA 01760 USA. [Bush, Jill A.] Coll New Jersey, Dept Hlth & Exercise Sci, Ewing, NJ 08618 USA. [Fragala, Maren S.] Quest Diagnost, Sports & Human Performance Diagnost, Athlete Hlth & Performance, Madison, NJ 07940 USA. [Looney, David P.] Univ Connecticut, Dept Kinesiol, Storrs, CT 06269 USA. [Triplett, N. Travis] Appalachian State Univ, Dept Hlth & Exercise Sci, Boone, NC 28608 USA. RP Kraemer, WJ (reprint author), Ohio State Univ, Dept Human Sci, A054 PAES Bldg,305W 17th Ave, Columbus, OH 43210 USA. EM kraemer.44@osu.edu FU Department of Defense FX The authors thank a dedicate group of subjects show made this project possible and colleagues at USARIEM who contributed to this project's completion. This project was funded by internal laboratory funds from the Department of Defense to the Exercise Physiology Division. Also, to Dr James Vogel for his vision and support and who propelled the accomplishments of the Division as then Director of the Exercise Physiology Division at the USARIEM. The views, opinions, and/or findings contained in this report are those of the author(s) and should not be construed as an official Department of the U.S. Army position, policy, or decision, unless so designated by other official documentation. NR 33 TC 5 Z9 5 U1 0 U2 3 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0196-9781 EI 1873-5169 J9 PEPTIDES JI Peptides PD FEB PY 2015 VL 64 BP 74 EP 81 DI 10.1016/j.peptides.2015.01.001 PG 8 WC Biochemistry & Molecular Biology; Endocrinology & Metabolism; Pharmacology & Pharmacy SC Biochemistry & Molecular Biology; Endocrinology & Metabolism; Pharmacology & Pharmacy GA CF8KM UT WOS:000352808100012 PM 25582563 ER PT J AU Michener, LA Kardouni, JR Sousa, CO Ely, JM AF Michener, Lori A. Kardouni, Joseph R. Sousa, Catarina O. Ely, Jacqueline M. TI Validation of a sham comparator for thoracic spinal manipulation in patients with shoulder pain SO MANUAL THERAPY LA English DT Article DE Sham; Rotator cuff; Thoracic spinal manipulation; Validity ID ROTATOR CUFF TENDINOPATHY; IMPINGEMENT SYNDROME; MUSCULOSKELETAL PAIN; RATING-SCALE; THERAPY; PHYSIOTHERAPY; RELIABILITY; MECHANISMS; TRIAL AB The evidence to guide use of spinal manipulative therapy (SMT) for patients with shoulder pain is limited. A validated sham comparator is needed to ascertain the unique effects of SMT. We investigated the plausibility of a thoracic sham-SMT comparator for SMT in patients with shoulder pain. Participants (n = 56) with subacromial impingement syndrome were randomized to thoracic SMT or a sham-SMT. An examiner blinded to group assignment took measures pre- and post-treatment of shoulder active range of motion (AROM) and perceived effects of the assigned intervention. Treatment consisted of six upper, middle and lower thoracic SMT or sham-SMT. The sham-SMT was identical to the SMT, except no thrust was applied. Believability as an active treatment was measured post-treatment. Believability as an active treatment was not different between groups (chi(2) = 2.19; p = 0.15). Perceptions of effects were not different between groups at pre-treatment (t = 0.12; p = 0.90) or post-treatment (t = 0.40; p = 0.69), and demonstrated equivalency with 95% confidence between groups at pre- and post-treatment. There was no significant change in shoulder flexion in either group over time, or in the sham-SMT for internal rotation (p > 0.05). The SMT group had an increase of 6.49 degrees in internal rotation over time (p = 0.04). The thoracic sham-SMT of this study is a plausible comparator for SMT in patients with shoulder pain. The sham-SMT was believable as an active treatment, perceived as having equal beneficial effects both when verbally described and after familiarization with the treatment, and has an inert effect on shoulder AROM. This comparator can be considered for used in clinical trials investigating thoracic SMT. (C) 2014 Elsevier Ltd. All rights reserved. C1 [Michener, Lori A.] Univ So Calif, Div Biokinesiol & Phys Therapy, Los Angeles, CA 90089 USA. [Kardouni, Joseph R.] US Army, Environm Med Res Inst, Natick, MA 01760 USA. [Sousa, Catarina O.] Univ Fed Rio Grande do Norte, Fac Ciencias Saude Trairi, Santa Cruz, RN, Brazil. [Ely, Jacqueline M.] Riverside Hlth Syst, Newport News, VA 23607 USA. RP Michener, LA (reprint author), Univ So Calif, Div Biokinesiol & Phys Therapy, 1540 E Alcazar St,CHP 155, Los Angeles, CA 90089 USA. EM lmichene@usc.edu FU NCATS NIH HHS [UL1 TR000058] NR 30 TC 5 Z9 5 U1 0 U2 0 PU CHURCHILL LIVINGSTONE PI EDINBURGH PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE, LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND SN 1356-689X EI 1532-2769 J9 MANUAL THER JI Man. Ther. PD FEB PY 2015 VL 20 IS 1 BP 171 EP 175 DI 10.1016/j.math.2014.08.008 PG 5 WC Rehabilitation SC Rehabilitation GA CF7WV UT WOS:000352768000027 PM 25261090 ER PT J AU Daddis, GA AF Daddis, Gregory A. TI When Soldiers Fall: How Americans Have Confronted Combat Losses from World War I to Afghanistan SO AMERICAN HISTORICAL REVIEW LA English DT Book Review C1 [Daddis, Gregory A.] US Mil Acad, West Point, NY 10996 USA. RP Daddis, GA (reprint author), US Mil Acad, West Point, NY 10996 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 0002-8762 EI 1937-5239 J9 AM HIST REV JI Am. Hist. Rev. PD FEB PY 2015 VL 120 IS 1 BP 276 EP 277 PG 3 WC History SC History GA CE8GM UT WOS:000352079900108 ER PT J AU Smith, TJ Wilson, MA Young, AJ Montain, SJ AF Smith, Tracey J. Wilson, Marques A. Young, Andrew J. Montain, Scott J. TI A suction blister model reliably assesses skin barrier restoration and immune response SO JOURNAL OF IMMUNOLOGICAL METHODS LA English DT Article DE Suction blister; Immune function; Inflammation ID PROINFLAMMATORY CYTOKINE PRODUCTION; RESPIRATORY-INFECTIONS; STRESS AB Skin wound healing models can be used to detect changes in immune function in response to interventions. This study used a test-retest format to assess the reliability of a skin suction blister procedure for quantitatively evaluating human immune function in repeated measures type studies. Up to eight suction blisters (similar to 30 mm(2)) were induced via suction on each participant's left and right forearm (randomized order; blister session 1 and 2), separated by approximately one week. Fluid was sampled from each blister, and the top layer of each blister was removed to reveal up to eight skin wounds. Fluid from each wound was collected 4, 7 and 24 h after blisters were induced, and proinflammatory cytokines were measured. Transepidermal water loss (TEWL), to assess skin barrier recovery, was measured daily at each wound site until values were within 90% of baseline values (i.e., unbroken skin). Sleep, stress and inflammation (i.e., factors that affect wound healing and immune function), preceding the blister induction, were assessed via activity monitors (Actical, Philips Respironics, Murrysville, Pennsylvania), the Perceived Stress Scale (PSS) and C-reactive protein (CRP), respectively. Area-under-the-curve and TEWL, between blister session 1 and 2, were compared using Pearson correlations and partial correlations (controlling for average nightly sleep, PSS scores and CRP). The suction blister method was considered reliable for assessing immune response and skin barrier recovery if correlation coefficients reached 0.7. Volunteers (n = 16; 12 M; 4 F) were 23 +/- 5 years [mean +/- SD]. Time to skin 'larder restoration was 4.9 +/- 0.8 and 4.8 +/- 0.9 days for sessions 1 and 2, respectively. Correlation coefficients for skin barrier restoration, IL-6, IL-8 and MIP-1 alpha were 0.9 (P < 0.0001), 0.7 (P = 0.008) and 0.9 (P < 0.0001), respectively. When average nightly sleep, PSS scores and CRP (i.e., percent difference between sessions 1 and 2) were taken into consideration, correlations in immune response between sessions 1 and 2 were improved for IL-8 (0.8, P = 0.002) and TNF-alpha (0.7, P = 0.02). The skin suction blister method is sufficiently reliable for assessing skin barrier restoration and immune responsiveness. This data can be used to determine sample sizes for cross-sectional or repeated-measures types of studies testing the impact of various stressors on immune response, and/or the efficacy of interventions to mitigate decrements in immune response to stress. Published by Elsevier B.V. C1 [Smith, Tracey J.; Wilson, Marques A.; Young, Andrew J.; Montain, Scott J.] US Army, Environm Med Res Inst, Mil Nutr Div, Natick, MA 01760 USA. RP Smith, TJ (reprint author), US Army, Environm Med Res Inst, 15 Kansas St,Bldg 42, Natick, MA 01760 USA. NR 15 TC 2 Z9 2 U1 1 U2 3 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0022-1759 EI 1872-7905 J9 J IMMUNOL METHODS JI J. Immunol. Methods PD FEB PY 2015 VL 417 BP 124 EP 130 DI 10.1016/j.jim.2015.01.002 PG 7 WC Biochemical Research Methods; Immunology SC Biochemistry & Molecular Biology; Immunology GA CE7UE UT WOS:000352046500014 PM 25585263 ER PT J AU Young, DA Novy, BB Zeller, GG Hale, R Hart, TC Truelove, EL AF Young, Douglas A. Novy, Brian B. Zeller, Gregory G. Hale, Robert Hart, Thomas C. Truelove, Edmond L. CA American Dental Association On Sci TI The American Dental Association Caries Classification System for Clinical Practice A report of the American Dental Association Council on Scientific Affairs SO JOURNAL OF THE AMERICAN DENTAL ASSOCIATION LA English DT Article DE Caries classification system; caries lesion classification; caries location; caries extent; caries activity; caries management ID RISK-ASSESSMENT; APPROXIMAL SURFACES; CARIOUS LESIONS; ORAL-HEALTH; MANAGEMENT; RELIABILITY; INDEX; MODEL AB Background. The caries lesion, the most commonly observed sign of dental caries disease, is the cumulative result of an imbalance in the dynamic demineralization and remineralization process that causes a net mineral loss over time. A classification system to categorize the location, site of origin, extent, and when possible, activity level of caries lesions consistently over time is necessary to determine which clinical treatments and therapeutic interventions are appropriate to control and treat these lesions. Methods. In 2008, the American Dental Association (ADA) convened a group of experts to develop an easy-to-implement caries classification system. The ADA Council on Scientific Affairs subsequently compiled information from these discussions to create the ADA Caries Classification System (CCS) presented in this article. Conclusions. The ADA CCS offers clinicians the capability to capture the spectrum of caries disease presentations ranging from clinically unaffected (sound) tooth structure to noncavitated initial lesions to extensively cavitated advanced lesions. The ADA CCS supports a broad range of clinical management options necessary to treat both noncavitated and cavitated caries lesions. Practical Implications. The ADA CCS is available for implementation in clinical practice to evaluate its usability, reliability, and validity. Feedback from clinical practitioners and researchers will allow system improvement. Use of the ADA CCS will offer standardized data that can be used to improve the scientific rationale for the treatment of all stages of caries disease. C1 [Young, Douglas A.] Univ Pacific, Dept Dent Practice, San Francisco, CA USA. [Novy, Brian B.] Loma Linda Univ, Dept Restorat Dent, Loma Linda, CA 92350 USA. [Zeller, Gregory G.] Univ Kentucky, Coll Dent, Oral Hlth Practice, Lexington, KY USA. [Hale, Robert] US Army Inst Surg Res, San Antonio, TX USA. [Hart, Thomas C.] Univ Illinois, Coll Dent, Dept Periodont, Chicago, IL USA. [Truelove, Edmond L.] Univ Washington, Sch Dent, Dept Oral Med, Seattle, WA 98195 USA. RP Truelove, EL (reprint author), Univ Washington, Dept Oral Med, 1959 Pacific St, Seattle, WA 98195 USA. EM edmondt@uw.edu NR 38 TC 11 Z9 13 U1 0 U2 4 PU AMER DENTAL ASSOC PI CHICAGO PA 211 E CHICAGO AVE, CHICAGO, IL 60611 USA SN 0002-8177 EI 1943-4723 J9 J AM DENT ASSOC JI J. Am. Dent. Assoc. PD FEB PY 2015 VL 146 IS 2 BP 79 EP 86 DI 10.1016/j.adaj.2014.11.018 PG 8 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA CE9GM UT WOS:000352152100010 PM 25637205 ER PT J AU Edlefsen, PT Rolland, M Hertz, T Tovanabutra, S Gartland, AJ Decamp, AC Magaret, CA Ahmed, H Gottardo, R Juraska, M Mccoy, C Larsen, BB Sanders-Buell, E Carrico, C Menis, S Bose, M Arroyo, MA O'Connell, RJ Nitayaphan, S Pitisuttithum, P Kaewkungwal, J Rerks-Ngarm, S Robb, ML Kirys, T Georgiev, IS Kwong, PD Scheffler, K Pond, SLK Carlson, JM Michael, NL Schief, WR Mullins, JI Kim, JH Gilbert, PB AF Edlefsen, Paul T. Rolland, Morgane Hertz, Tomer Tovanabutra, Sodsai Gartland, Andrew J. decamp, Allan C. Magaret, Craig A. Ahmed, Hasan Gottardo, Raphael Juraska, Michal McCoy, Connor Larsen, Brendan B. Sanders-Buell, Eric Carrico, Chris Menis, Sergey Bose, Meera Arroyo, Miguel A. O'Connell, Robert J. Nitayaphan, Sorachai Pitisuttithum, Punnee Kaewkungwal, Jaranit Rerks-Ngarm, Supachai Robb, Merlin L. Kirys, Tatsiana Georgiev, Ivelin S. Kwong, Peter D. Scheffler, Konrad Pond, Sergei L. Kosakovsky Carlson, Jonathan M. Michael, Nelson L. Schief, William R. Mullins, James I. Kim, Jerome H. Gilbert, Peter B. CA RV144 Sequencing Team TI Comprehensive Sieve Analysis of Breakthrough HIV-1 Sequences in the RV144 Vaccine Efficacy Trial SO PLOS COMPUTATIONAL BIOLOGY LA English DT Article ID COMPETING RISKS; PEPTIDE BINDING; CELL RESPONSES; SUBTYPE-B; PROTEIN; ENVELOPE; NEUTRALIZATION; EPITOPES; ESCAPE; GP120 AB The RV144 clinical trial showed the partial efficacy of a vaccine regimen with an estimated vaccine efficacy (VE) of 31% for protecting low-risk Thai volunteers against acquisition of HIV-1. The impact of vaccine-induced immune responses can be investigated through sieve analysis of HIV-1 breakthrough infections (infected vaccine and placebo recipients). A V1/V2-targeted comparison of the genomes of HIV-1 breakthrough viruses identified two V2 amino acid sites that differed between the vaccine and placebo groups. Here we extended the V1/V2 analysis to the entire HIV-1 genome using an array of methods based on individual sites, k-mers and genes/proteins. We identified 56 amino acid sites or "signatures" and 119 k-mers that differed between the vaccine and placebo groups. Of those, 19 sites and 38 k-mers were located in the regions comprising the RV144 vaccine (Env-gp120, Gag, and Pro). The nine signature sites in Env-gp120 were significantly enriched for known antibody-associated sites (p = 0.0021). In particular, site 317 in the third variable loop (V3) overlapped with a hotspot of antibody recognition, and sites 369 and 424 were linked to CD4 binding site neutralization. The identified signature sites significantly covaried with other sites across the genome (mean = 32.1) more than did non-signature sites (mean = 0.9) (p < 0.0001), suggesting functional and/or structural relevance of the signature sites. Since signature sites were not preferentially restricted to the vaccine immunogens and because most of the associations were insignificant following correction for multiple testing, we predict that few of the genetic differences are strongly linked to the RV144 vaccine-induced immune pressure. In addition to presenting results of the first complete-genome analysis of the breakthrough infections in the RV144 trial, this work describes a set of statistical methods and tools applicable to analysis of breakthrough infection genomes in general vaccine efficacy trials for diverse pathogens. C1 [Edlefsen, Paul T.; Hertz, Tomer; Gartland, Andrew J.; decamp, Allan C.; Magaret, Craig A.; Ahmed, Hasan; Gottardo, Raphael; Juraska, Michal; McCoy, Connor; Gilbert, Peter B.] Fred Hutchinson Canc Res Ctr, Vaccine & Infect Dis Div, Seattle, WA 98104 USA. [Rolland, Morgane; Tovanabutra, Sodsai; Sanders-Buell, Eric; Bose, Meera; Robb, Merlin L.; Michael, Nelson L.; Kim, Jerome H.] US Mil HIV Res Program, Silver Spring, MD USA. [Hertz, Tomer] Ben Gurion Univ Negev, Fac Hlth Sci, Shraga Segal Dept Microbiol Immunol & Genet, IL-84105 Beer Sheva, Israel. [Hertz, Tomer] Ben Gurion Univ Negev, Natl Inst Biotechnol Negev, IL-84105 Beer Sheva, Israel. [Larsen, Brendan B.; Mullins, James I.] Univ Washington, Dept Microbiol, Seattle, WA 98195 USA. [Carrico, Chris; Menis, Sergey; Schief, William R.] Univ Washington, Dept Biochem, Seattle, WA 98195 USA. [Carrico, Chris; Menis, Sergey; Schief, William R.] Scripps Res Inst, IAVI Neutralizing Antibody Ctr, La Jolla, CA 92037 USA. [Carrico, Chris; Menis, Sergey; Schief, William R.] Scripps Res Inst, Dept Immunol & Microbial Sci, La Jolla, CA 92037 USA. [Arroyo, Miguel A.; Nitayaphan, Sorachai; Kaewkungwal, Jaranit] AFRIMS, Royal Thai Army Component, Bangkok, Thailand. [O'Connell, Robert J.] AFRIMS, US Army Component, Bangkok, Thailand. [Pitisuttithum, Punnee] Mahidol Univ, Fac Trop Med, Bangkok, Thailand. [Rerks-Ngarm, Supachai] Thai Minist Publ Hlth, CDC Dept, Nonthaburi, Thailand. [Kirys, Tatsiana; Georgiev, Ivelin S.; Kwong, Peter D.] NIAID, Vaccine Res Ctr, NIH, Bethesda, MD 20892 USA. [Scheffler, Konrad; Pond, Sergei L. Kosakovsky] Univ Calif San Diego, Dept Med, La Jolla, CA 92093 USA. [Carlson, Jonathan M.] Microsoft Res, eSience Res Grp, Redmond, WA USA. [Schief, William R.] Ragon Inst MGH MIT & Harvard, Cambridge, MA 02139 USA. RP Edlefsen, PT (reprint author), Fred Hutchinson Canc Res Ctr, Vaccine & Infect Dis Div, 1124 Columbia St, Seattle, WA 98104 USA. EM pedlefse@fredhutch.org RI Hertz, Tomer/S-5744-2016 OI Hertz, Tomer/0000-0002-0561-1578 FU U.S. Army Medical Research and Material Command (USAMRMC) [Y1-AI-2642-12]; National Institutes of Allergy and Infectious Diseases; Department of Veterans Affairs, Veterans Health Administration, Office of Research and development; Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. [W81XWH-07-2-0067]; U.S. Department of Defense (DOD) [W81XWH-07-2-0067]; Vaccine Research Center, NIAID/NIH; NIH [2R37AI05465-11] FX This study was supported in part by an Interagency Agreement Y1-AI-2642-12 between U.S. Army Medical Research and Material Command (USAMRMC), the National Institutes of Allergy and Infectious Diseases, and by the Department of Veterans Affairs, Veterans Health Administration, Office of Research and development. This work was also supported by a cooperative agreement (W81XWH-07-2-0067) between the Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., and the U.S. Department of Defense (DOD). Additional support was provided by Intramural funding of the Vaccine Research Center, NIAID/NIH and to PBG through the NIH grant 2R37AI05465-11. The content is solely the responsibility of the authors and does not necessarily represent the official views of the U.S. Department of Health and Human Services, National Institute for Allergy and Infectious Diseases, the Department of the Army, the Department of Defense, or the Department of Veterans Affairs. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 57 TC 12 Z9 12 U1 1 U2 10 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1553-734X EI 1553-7358 J9 PLOS COMPUT BIOL JI PLoS Comput. Biol. PD FEB PY 2015 VL 11 IS 2 AR UNSP e1003973 DI 10.1371/journal.pcbi.1003973 PG 37 WC Biochemical Research Methods; Mathematical & Computational Biology SC Biochemistry & Molecular Biology; Mathematical & Computational Biology GA CE8GX UT WOS:000352081000005 PM 25646817 ER PT J AU Iiames, JS Congalton, RG Lewis, TE Pilant, AN AF Iiames, John S. Congalton, Russell G. Lewis, Timothy E. Pilant, Andrew N. TI Uncertainty Analysis in the Creation of a Fine-Resolution Leaf Area Index (LAI) Reference Map for Validation of Moderate Resolution LAI Products SO REMOTE SENSING LA English DT Article ID PINUS-TAEDA L.; LOBLOLLY-PINE; ACCURACY ASSESSMENT; UNITED-STATES; IMAGE CLASSIFICATION; VEGETATION INDEXES; GROWTH; STANDS; FERTILIZATION; FORESTS AB The validation process for a moderate resolution leaf area index (LAI) product (i.e., MODIS) involves the creation of a high spatial resolution LAI reference map (Lai-RM), which when scaled to the moderate LAI resolution (i.e., > 1 km) allows for comparison and analysis with this LAI product. This research addresses two major sources of uncertainty in the creation of the LAI-RM: (1) the uncertainty associated with the indirect in situ optical measurements of southeastern United States needle-leaf LAI and (2) the uncertainty in the process of classifying land cover (LC). Uncertainty within the loblolly pine (Pinus taeda) in situ data collection was highest for the assessment of the plant area index (PAI), L-e (27.2%), and the woody-to-total ratio, alpha, (30.6%). The needle-to-shoot ratio, lambda(E), and the element clumping index, omega(E), contributed 14.9% and 9.3%, respectively, to the uncertainty in the calculation of LAI. Combining LC differences (3.4%) with the uncertainty within the loblolly pine component resulted in doubling the LAI-RM variability (sigma = 0.50 to sigma = 0.97) at the 1 km(2) validation site located in Appomattox, Virginia, USA. C1 [Iiames, John S.; Pilant, Andrew N.] US EPA, Res Triangle Pk, NC 27711 USA. [Congalton, Russell G.] Univ New Hampshire, Dept Nat Resources & Environm, Durham, NH 03824 USA. [Lewis, Timothy E.] US Army Corps Engn, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Iiames, JS (reprint author), US EPA, 109 TW Alexander Dr MD E243-05, Res Triangle Pk, NC 27711 USA. EM iiames.john@epa.gov; russ.congalton@unh.edu; timothy.e.lewis@usace.army.mil; pilant.drew@epa.gov NR 62 TC 2 Z9 2 U1 3 U2 8 PU MDPI AG PI BASEL PA POSTFACH, CH-4005 BASEL, SWITZERLAND SN 2072-4292 J9 REMOTE SENS-BASEL JI Remote Sens. PD FEB PY 2015 VL 7 IS 2 BP 1397 EP 1421 DI 10.3390/rs70201397 PG 25 WC Remote Sensing SC Remote Sensing GA CF2TQ UT WOS:000352400900012 ER PT J AU Ivins, BJ Lange, RT Cole, WR Kane, R Schwab, KA Iverson, GL AF Ivins, Brian J. Lange, Rael T. Cole, Wesley R. Kane, Robert Schwab, Karen A. Iverson, Grant L. TI Using Base Rates of Low Scores to Interpret the ANAM4 TBI-MIL Battery Following Mild Traumatic Brain Injury SO ARCHIVES OF CLINICAL NEUROPSYCHOLOGY LA English DT Article DE Mild traumatic brain injury; Cognitive testing; Military; Low scores; Base rates ID HEALTHY OLDER-ADULTS; NEUROPSYCHOLOGICAL TEST-PERFORMANCE; COGNITIVE IMPAIRMENT; MEMORY SCORES; VALIDATION; DIAGNOSIS; CRITERIA; TESTS AB Base rates of low ANAM4 TBI-MIL scores were calculated in a convenience sample of 733 healthy male active duty soldiers using available military reference values for the following cutoffs: <= 2nd percentile (2 SDs), <= 5th percentile, <10th percentile, and <16th percentile (1 SD). Rates of low scores were also calculated in 56 active duty male soldiers who sustained an mTBI an average of 23 days (SD = 36.1) prior. 22.0% of the healthy sample and 51.8% of the mTBI sample had two or more scores below 1 SD (i.e., 16th percentile). 18.8% of the healthy sample and 44.6% of the mTBI sample had one or more scores <= 5th percentile. Rates of low scores in the healthy sample were influenced by cutoffs and race/ethnicity. Importantly, some healthy soldiers obtain at least one low score on ANAM4. These base rate analyses can improve the methodology for interpreting ANAM4 performance in clinical practice and research. C1 [Ivins, Brian J.; Schwab, Karen A.] Def & Vet Brain Injury Ctr, Headquarters, Div Res, Silver Spring, MD 20910 USA. [Ivins, Brian J.; Lange, Rael T.; Cole, Wesley R.] GDIT, Fairfax, VA USA. [Lange, Rael T.; Iverson, Grant L.] Walter Reed Natl Mil Med Ctr, Def & Vet Brain Injury Ctr, Bethesda, MD USA. [Lange, Rael T.] Univ British Columbia, Vancouver, BC V5Z 1M9, Canada. [Cole, Wesley R.] Womack Army Med Ctr, Def & Vet Brain Injury Ctr, Ft Bragg, NC USA. [Kane, Robert] Georgetown Univ, Washington, DC USA. [Schwab, Karen A.] ARK Solut Inc, Reston, AR USA. [Iverson, Grant L.] Harvard Univ, Sch Med, Dept Phys Med & Rehabil,Red Sox Fdn, Spaulding Rehabil Hosp,Massachusetts Gen Hosp,Spo, Boston, MA USA. [Iverson, Grant L.] Massachusetts Gen Hosp, Home Base Program, Boston, MA 02114 USA. RP Ivins, BJ (reprint author), Def & Vet Brain Injury Ctr, 1335 East West Highway,Suite 6-100, Silver Spring, MD 20910 USA. EM brian.j.ivins.ctr@mail.mil NR 38 TC 1 Z9 1 U1 0 U2 2 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 0887-6177 EI 1873-5843 J9 ARCH CLIN NEUROPSYCH JI Arch. Clin. Neuropsychol. PD FEB PY 2015 VL 30 IS 1 BP 26 EP 38 DI 10.1093/arclin/acu072 PG 13 WC Psychology, Clinical; Psychology SC Psychology GA CE6BA UT WOS:000351919400003 PM 25526791 ER PT J AU Lester, PB Taylor, LC Hawkins, SA Landry, L AF Lester, Paul B. Taylor, Lauren C. Hawkins, Stacy Ann Landry, Lisa TI Current Directions in Military Health-care Provider Resilience SO CURRENT PSYCHIATRY REPORTS LA English DT Article DE Military; Resilience; Mental health; Provider; Compassion fatigue; Burnout; PTSD; Depression; Development; Training ID SECONDARY TRAUMATIC STRESS; PROFESSIONALS; DEPLOYMENT; BURNOUT AB After more than a decade of war, the US military continues to place significant emphasis on psychological health and resilience. While research and programs that focus on the broader military community's resilience continue to emerge, less is known about and until recently little focus has been placed on military medical provider resilience. In this article, we review the literature on military medical provider resilience, provide an overview of the programmatic and technological advances designed to sustain and develop military medical provider resilience, and finally offer recommendations for future research. C1 [Lester, Paul B.; Taylor, Lauren C.; Hawkins, Stacy Ann] Army Analyt Grp, Res Facilitat Lab, Monterey, CA 93940 USA. [Landry, Lisa] US Army Med Dept Ctr & Sch, Dept Behav Hlth Sci, Ft Sam Houston, TX USA. RP Lester, PB (reprint author), Army Analyt Grp, Res Facilitat Lab, Monterey, CA 93940 USA. EM paul.b.lester.mil@mail.mil; lauren.c.taylor4.ctr@mail.mil; Stacy.a.hawkins5.ctr@mail.mil; susan.landry.civ@mail.mil NR 23 TC 0 Z9 0 U1 2 U2 5 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1523-3812 EI 1535-1645 J9 CURR PSYCHIAT REP JI Curr. Psychiatry Rep. PD FEB PY 2015 VL 17 IS 2 AR 6 DI 10.1007/s11920-014-0539-8 PG 7 WC Psychiatry SC Psychiatry GA CD6XC UT WOS:000351232700006 PM 25617036 ER PT J AU Panero, WR Pigott, JS Reaman, DM Kabbes, JE Liu, ZX AF Panero, Wendy R. Pigott, Jeffrey S. Reaman, Daniel M. Kabbes, Jason E. Liu, Zhenxian TI Dry (Mg,Fe)SiO3 perovskite in the Earth's lower mantle SO JOURNAL OF GEOPHYSICAL RESEARCH-SOLID EARTH LA English DT Article DE perovskite; mantle; water; melting; viscosity ID MAGNESIUM-SILICATE PEROVSKITE; NOMINALLY ANHYDROUS MINERALS; TOTAL-ENERGY CALCULATIONS; WATER STORAGE CAPACITY; WAVE BASIS-SET; TRANSITION-ZONE; HIGH-PRESSURE; HYDROUS RINGWOODITE; MGSIO3 PEROVSKITE; SINGLE-CRYSTAL AB Combined synthesis experiments and first-principles calculations show that MgSiO3-perovskite with minor Al or Fe does not incorporate significant OH under lower mantle conditions. Perovskite, stishovite, and residual melt were synthesized from natural Bamble enstatite samples (Mg/(Fe+Mg)=0.89 and 0.93; Al2O3<0.1wt % with 35 and 2065ppm weight H2O, respectively) in the laser-heated diamond anvil cell at 1600-2000K and 25-65GPa. Combined Fourier transform infrared spectroscopy, X-ray diffraction, and ex situ transmission electron microscopy analysis demonstrates little difference in the resulting perovskite as a function of initial water content. Four distinct OH vibrational stretching bands are evident upon cooling below 100K (3576, 3378, 3274, and 3078cm(-1)), suggesting four potential bonding sites for OH in perovskite with a maximum water content of 220ppm weight H2O, and likely no more than 10ppm weight H2O. Complementary, Fe-free, first-principles calculations predict multiple potential bonding sites for hydrogen in perovskite, each with significant solution enthalpy (0.2eV/defect). We calculate that perovskite can dissolve less than 37ppm weight H2O (400ppm H/Si) at the top of the lower mantle, decreasing to 31ppm weight H2O (340ppm H/Si) at 125GPa and 3000K in the absence of a melt or fluid phase. We propose that these results resolve a long-standing debate of the perovskite melting curve and explain the order-of-magnitude increase in viscosity from upper to lower mantle. C1 [Panero, Wendy R.; Pigott, Jeffrey S.; Kabbes, Jason E.] Ohio State Univ, Sch Earth Sci, Columbus, OH 43210 USA. [Reaman, Daniel M.] US Army Res Lab, RDRL WMRD, Aberdeen, MD USA. [Liu, Zhenxian] Carnegie Inst Sci, Geophys Lab, Washington, DC USA. RP Panero, WR (reprint author), Ohio State Univ, Sch Earth Sci, Columbus, OH 43210 USA. EM panero.1@osu.edu RI Panero, Wendy/C-9602-2009 FU NSF EAR [09-55647]; Ohio Supercomputer Center [PAS0238-1]; COMPRES, the Consortium for Materials Properties Research in Earth Sciences under NSF [EAR 06-49658]; U.S. Department of Energy, Office of Science, Office of Basic Energy Sciences [DE-AC02-98CH10886] FX This work was supported by NSF EAR 09-55647 to WRP. Calculations were performed on the Ohio Supercomputer Center with award PAS0238-1. Thanks to Lars Stixrude and Abby Kavner for useful discussions, Tao Zhou for the loan of the Janis cryostat, and assistance from Cameron Begg, Daniel Huber, Billy Eymold, and Henk Colijn. The use of the U2A and X17C beamlines at the National Synchrotron Light Source beamline is supported by COMPRES, the Consortium for Materials Properties Research in Earth Sciences under NSF cooperative agreement EAR 06-49658 and by the U.S. Department of Energy, Office of Science, Office of Basic Energy Sciences, under contract DE-AC02-98CH10886. NR 81 TC 8 Z9 9 U1 4 U2 34 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA SN 2169-9313 EI 2169-9356 J9 J GEOPHYS RES-SOL EA JI J. Geophys. Res.-Solid Earth PD FEB PY 2015 VL 120 IS 2 BP 894 EP 908 DI 10.1002/2014JB011397 PG 15 WC Geochemistry & Geophysics SC Geochemistry & Geophysics GA CE0BD UT WOS:000351466000015 ER PT J AU Bocan, TM Panchal, RG Bavari, S AF Bocan, Thomas M. Panchal, Rekha G. Bavari, Sina TI Applications of In Vivo Imaging in the Evaluation of the Pathophysiology of Viral and Bacterial Infections and in Development of Countermeasures to BSL3/4 Pathogens SO MOLECULAR IMAGING AND BIOLOGY LA English DT Review DE In vivo imaging; MRI; PET; SPECT; CT; Optical; Ultrasound; BSL3/4 pathogens ID POSITRON-EMISSION-TOMOGRAPHY; VIRUS THYMIDINE KINASE; REPORTER GENE; BURKHOLDERIA-PSEUDOMALLEI; MYCOBACTERIUM-TUBERCULOSIS; PLAQUE INFLAMMATION; PET; MICE; THERAPY; EXPRESSION AB While preclinical and clinical imaging have been applied to drug discovery/development and characterization of disease pathology, few examples exist where imaging has been used to evaluate infectious agents or countermeasures to biosafety level (BSL)3/4 threat agents. Viruses engineered with reporter constructs, i.e., enzymes and receptors, which are amenable to detection by positron emission tomography (PET), single photon emission tomography (SPECT), or magnetic resonance imaging (MRI) have been used to evaluate the biodistribution of viruses containing specific therapeutic or gene transfer payloads. Bioluminescence and nuclear approaches involving engineered reporters, direct labeling of bacteria with radiotracers, or tracking bacteria through their constitutively expressed thymidine kinase have been utilized to characterize viral and bacterial pathogens post-infection. Most PET, SPECT, CT, or MRI approaches have focused on evaluating host responses to the pathogens such as inflammation, brain neurochemistry, and structural changes and on assessing the biodistribution of radiolabeled drugs. Imaging has the potential when applied preclinically to the development of countermeasures against BSL3/4 threat agents to address the following: (1) presence, biodistribution, and time course of infection in the presence or absence of drug; (2) binding of the therapeutic to the target; and (3) expression of a pharmacologic effect either related to drug mechanism, efficacy, or safety. Preclinical imaging could potentially provide real-time dynamic tools to characterize the pathogen and animal model and for developing countermeasures under the U.S. FDA Animal Rule provision with high confidence of success and clinical benefit. C1 [Bocan, Thomas M.; Panchal, Rekha G.; Bavari, Sina] US Army, Med Res Inst Infect Dis, Mol & Translat Sci, Ft Detrick, MD 21702 USA. [Bocan, Thomas M.] Geneva Fdn, Tacoma, WA 98402 USA. RP Bocan, TM (reprint author), US Army, Med Res Inst Infect Dis, Mol & Translat Sci, 1425 Porter St, Ft Detrick, MD 21702 USA. EM Thomas.m.bocan.ctr@mail.mil FU Geneva Foundation FX We would like to acknowledge Mr. William F. Discher for his assistance in drawing the two figures and Dr. Jennifer Ojeda for her scientific input into the preparation of Fig. 2. Funding was provided by The Geneva Foundation. NR 98 TC 1 Z9 1 U1 2 U2 7 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1536-1632 EI 1860-2002 J9 MOL IMAGING BIOL JI Mol. Imaging. Biol. PD FEB PY 2015 VL 17 IS 1 BP 4 EP 17 DI 10.1007/s11307-014-0759-7 PG 14 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA CD4YV UT WOS:000351093700002 PM 25008802 ER PT J AU Piekiel, NW Morris, CJ Churaman, WA Cunningham, ME Lunking, DM Currano, LJ AF Piekiel, Nicholas W. Morris, Christopher J. Churaman, Wayne A. Cunningham, Michael E. Lunking, David M. Currano, Luke J. TI Combustion and Material Characterization of Highly Tunable On-Chip Energetic Porous Silicon SO PROPELLANTS EXPLOSIVES PYROTECHNICS LA English DT Article DE Porous silicon; On-chip energetic materials; Tunable combustion; Sodium perchlorate ID EXPLOSIVE DEVICES; MICROCHANNELS; THERMITE; FILMS AB We present a comprehensive investigation into the tunable combustion of on-chip porous silicon energetic materials. The exothermic reaction occurs between high surface area nanoscale porous silicon and a solution-deposited sodium perchlorate oxidizer that penetrates each pore. The resulting burn rates spanned three orders of magnitude, from 5.2 to 1950ms(-1). Material properties of the porous silicon films were characterized using gas adsorption porosimetry, SEM, and profilometry, over specific surface areas between 191 and 901m(2)g(-1), and porosities between 49 and 80%. Combustion events were characterized using high speed imaging and bomb calorimetry. Results revealed that combustion depended on several material properties including surface area and porosity of the porous silicon substrate, with the peak flame speed occurring at 895m(2)g(-1) specific surface area, 3.32nm pore size, and 72% porosity. Measured heat of combustion increased with porosity over the range of 65-75%, up to 22.5kJg(-1) of porous silicon at 75% porosity. These measurements along with gravimetric determinations of oxidizer pore loading suggest that the system was typically fuel rich, with macroscopic morphology and porous silicon film mechanical integrity generally limiting the realistic range of porosity values to less than stoichiometric conditions. C1 [Piekiel, Nicholas W.; Morris, Christopher J.; Churaman, Wayne A.; Cunningham, Michael E.; Lunking, David M.] US Army Res Lab, Sensors & Elect Devices Directorate, Adelphi, MD 20783 USA. [Currano, Luke J.] Johns Hopkins Univ, Appl Phys Lab, Laurel, MD 20723 USA. RP Piekiel, NW (reprint author), US Army Res Lab, Sensors & Elect Devices Directorate, Adelphi, MD 20783 USA. EM nicholas.piekiel.ctr@mail.mil FU Oak Ridge Associated Universities (ORAU) FX The authors would like to thank Collin Becker for useful discussions throughout this work, and Brian Isaacson for assistance in sample fabrication. We would also like to thank Oak Ridge Associated Universities (ORAU) for funding for this project. NR 39 TC 8 Z9 8 U1 1 U2 28 PU WILEY-V C H VERLAG GMBH PI WEINHEIM PA POSTFACH 101161, 69451 WEINHEIM, GERMANY SN 0721-3115 EI 1521-4087 J9 PROPELL EXPLOS PYROT JI Propellants Explos. Pyrotech. PD FEB PY 2015 VL 40 IS 1 BP 16 EP 26 DI 10.1002/prep.201400140 PG 11 WC Chemistry, Applied; Engineering, Chemical SC Chemistry; Engineering GA CC7LS UT WOS:000350549700004 ER PT J AU Edla, S Reisner, AT Liu, JB Convertino, VA Carter, R Reifman, J AF Edla, Shwetha Reisner, Andrew T. Liu, Jianbo Convertino, Victor A. Carter, Robert, III Reifman, Jaques TI Is heart rate variability better than routine vital signs for prehospital identification of major hemorrhage? SO AMERICAN JOURNAL OF EMERGENCY MEDICINE LA English DT Article ID TRAUMA PATIENTS; LIFESAVING INTERVENTIONS; PERIOD VARIABILITY; RATE COMPLEXITY; COMBAT CASUALTIES; RATE RESPONSE; PREDICTION; MORTALITY; TRANSPORT; CAUTIONS AB Objective: During initial assessment of trauma patients, metrics of heart rate variability (HRV) have been associated with high- risk clinical conditions. Yet, despite numerous studies, the potential of HRV to improve clinical outcomes remains unclear. Our objectivewas to evaluate whether HRV metrics provide additional diagnostic information, beyond routine vital signs, for making a specific clinical assessment: identification of hemorrhaging patients who receive packed red blood cell (PRBC) transfusion. Methods: Adult prehospital trauma patients were analyzed retrospectively, excluding those who lacked a complete set of reliable vital signs and a clean electrocardiogram for computation of HRV metrics. We also excluded patients who did not survive to admission. The primary outcome was hemorrhagic injury plus different PRBC transfusion volumes. We performed multivariate regression analysis using HRV metrics and routine vital signs to test the hypothesis that HRV metrics could improve the diagnosis of hemorrhagic injury plus PRBC transfusion vs routine vital signs alone. Results: As univariate predictors, HRV metrics in a data set of 402 subjects had comparable areas under receiver operating characteristic curves compared with routine vital signs. In multivariate regression models containing routine vital signs, HRV parameters were significant (P<.05) but yielded areas under receiver operating characteristic curves with minimal, nonsignificant improvements (+0.00 to +0.05). Conclusions: A novel diagnostic test should improve diagnostic thinking and allowfor better decision making in a significant fraction of cases. Our findings do not support that HRV metrics add value over routine vital signs in terms of prehospital identification of hemorrhaging patients who receive PRBC transfusion. Published by Elsevier Inc. C1 [Edla, Shwetha; Liu, Jianbo; Reifman, Jaques] US Army, Med Res & Mat Command, Telemed & Adv Technol Res Ctr, Software Applicat Inst,Dept Def Biotechnol High P, Ft Detrick, MD 21702 USA. [Reisner, Andrew T.] Massachusetts Gen Hosp, Dept Emergency Med, Boston, MA 02114 USA. [Convertino, Victor A.; Carter, Robert, III] US Army, Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Reifman, J (reprint author), US Army, Med Res & Mat Command, Telemed & Adv Technol Res Ctr, ATTN MCMR TT,Software Applicat Inst,Dept Def Biot, 504 Scott St, Ft Detrick, MD 21702 USA. EM jaques.reifman.civ@mail.mil FU US Department of Defense Medical Research and Development Program [D10_I_AR_J6_773]; Combat Casualty Care Research Area Directorate of the US Army Medical Research and Materiel Command, Fort Detrick, MD, USA FX This work was supported by the US Department of Defense Medical Research and Development Program (grant no. D10_I_AR_J6_773) and by the Combat Casualty Care Research Area Directorate of the US Army Medical Research and Materiel Command, Fort Detrick, MD, USA. The study sponsors did not have any role in the study design, data collection, analysis and interpretation of data, report writing, or the decision to submit the article for publication. The opinions and assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the US Army or of the US Department of Defense. This article has been approved for public release with unlimited distribution. NR 42 TC 2 Z9 2 U1 0 U2 0 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0735-6757 EI 1532-8171 J9 AM J EMERG MED JI Am. J. Emerg. Med. PD FEB PY 2015 VL 33 IS 2 BP 254 EP 261 DI 10.1016/j.ajem.2014.11.046 PG 8 WC Emergency Medicine SC Emergency Medicine GA CC6AW UT WOS:000350447900022 PM 25534122 ER PT J AU Larentzos, JP Rice, BM Byrd, EFC Weingarten, NS Lill, JV AF Larentzos, James P. Rice, Betsy M. Byrd, Edward F. C. Weingarten, N. Scott Lill, James V. TI Parameterizing Complex Reactive Force Fields Using Multiple Objective Evolutionary Strategies (MOES). Part 1: ReaxFF Models for Cyclotrimethylene Trinitramine (RDX) and 1,1-Diamino-2,2-dinitroethene (FOX-7) SO JOURNAL OF CHEMICAL THEORY AND COMPUTATION LA English DT Article ID MOLECULAR-DYNAMICS SIMULATIONS; NEURAL-NETWORKS; THERMAL-DECOMPOSITION; MULTIOBJECTIVE OPTIMIZATION; INTERMOLECULAR INTERACTIONS; ALGORITHMS; HYDROCARBONS; STATE; SILICON; CARBON AB ReaxFF (van Duin, A.C.T.; Dasgupta, S.; Lorant, F.; Goddard, W.A. J. Phys. Chem. A, 2001, 105, 9396-9409) reactive potentials are parametrized for cyclotrimethylene trinitramine (RDX) and 1,1-diamino-2,2-dinitroethene (FOX-7) in a novel application combining data envelopment analysis and a modern self-adaptive evolutionary algorithm to optimize multiple objectives simultaneously and map the entire family of solutions. In order to correct the poor crystallographic parameters predicted by ReaxFF using its base parametrization (Strachan, A.; van Duin, A. C. T.; Chakraborty, D.; Dasgupta S.; Goddard, W. A. Phys. Rev. Lett., 2003, 91, 098301), we augmented the existing training set data used for parametrization with additional (SAPT)DFT calculations of RDX and FOX-7 dimer interactions. By adjusting a small subset of the ReaxFF parameters that govern long-range interactions, the evolutionary algorithm approach converges on a family of solutions that best describe crystallographic parameters through simultaneous optimization of the objective functions. Molecular dynamics calculations of RDX and FOX-7 are conducted to assess the quality of the force fields, resulting in parametrizations that improve the overall prediction of the crystal structures. C1 [Larentzos, James P.] US Army Res Lab, Engil Corp, High Technol Serv Grp, Aberdeen Proving Ground, MD 21005 USA. [Rice, Betsy M.; Byrd, Edward F. C.; Weingarten, N. Scott] US Army Res Lab, Energet Mat Sci Branch, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. [Lill, James V.] US Air Force Res Lab, Engil Corp, High Technol Serv Grp, Wright Patterson AFB, OH 45433 USA. RP Weingarten, NS (reprint author), US Army Res Lab, Energet Mat Sci Branch, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. EM neil.s.weingarten.civ@mail.mil FU Department of Defense HPCMP Software Application Institute for Multiscale Reactive Modeling of Insensitive Munitions FX The authors acknowledge Dr. Anthony Yau for insightful discussions regarding ReaxFF and his help in developing the MOES software. Additionally, the authors gratefully acknowledge Prof. Adri van Duin of Penn State University who generously provided a copy of his reac program that served as the basis for the ReaxFF training set used by MOBS and who offered guidance through numerous insightful discussions. The authors also thank Dr. Shawn Brown of the Pittsburgh Supercomputing Center who performed the initial MPI parallelization of MOBS. The authors acknowledge the computational resources and PETTT software support from the DoD High Performance Computing Modernization Program (HPCMP). The HPCMP provided the supercomputing resources under a Computing Challenge Project entitled, "Construction of Accurate Reactive Potentials for Large Scale Molecular Dynamics Simulations." This time was made available at the DoD Supercomputing Resource Centers at the U.S. Army Research Laboratory, Air Force Research Laboratory, and Engineer Research and Development Center. The authors acknowledge support by the Department of Defense HPCMP Software Application Institute for Multiscale Reactive Modeling of Insensitive Munitions. NR 59 TC 10 Z9 10 U1 3 U2 40 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1549-9618 EI 1549-9626 J9 J CHEM THEORY COMPUT JI J. Chem. Theory Comput. PD FEB PY 2015 VL 11 IS 2 BP 381 EP 391 DI 10.1021/ct500788c PG 11 WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical SC Chemistry; Physics GA CB9EI UT WOS:000349934400003 PM 26580902 ER PT J AU Rice, BM Larentzos, JP Byrd, EFC Weingarten, NS AF Rice, Betsy M. Larentzos, James P. Byrd, Edward F. C. Weingarten, N. Scott TI Parameterizing Complex Reactive Force Fields Using Multiple Objective Evolutionary Strategies (MOES): Part 2: Transferability of ReaxFF Models to C-H-N-O Energetic Materials SO JOURNAL OF CHEMICAL THEORY AND COMPUTATION LA English DT Article ID MULTIOBJECTIVE DECISION-MAKING; POST-PARETO OPTIMALITY; CRYSTAL-STRUCTURE; MOLECULAR-DYNAMICS; SIMULATIONS; 1,3,5-TRIAMINO-2,4,6-TRINITROBENZENE AB The Multiple Objective Evolutionary Strategies (MOES) algorithm was used to parametrize force fields having the form of the reactive models ReaxFF (van Duin, A. C. T.; Dasgupta, S.; Lorant, F.; Goddard, W. A. J. Phys. Chem. A 2001, 105, 9396) and ReaxFF-lg (Liu, L.; Liu, Y.; Zybin, S. V.; Sun, H.; Goddard, W. A. J. Phys. Chem. A 2011, 115, 11016) in an attempt to produce equal or superior ambient state crystallographic structural results for cyclotrimethylene trinitramine (RDX). Promising candidates were then subjected to molecular dynamics simulations of five other well-known conventional energetic materials to assess the degree of transferability of the models. Two models generated through the MOES search were shown to have performance better than or as good as ReaxFF-lg in describing the six energetic systems modeled. This study shows that MOES is an effective and efficient method to develop complex force fields. C1 [Rice, Betsy M.; Byrd, Edward F. C.; Weingarten, N. Scott] US Army Res Lab, Energet Mat Sci Branch, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. [Larentzos, James P.] US Army Res Lab, Engil Corp, High Technol Serv Grp, Aberdeen Proving Ground, MD 21005 USA. RP Weingarten, NS (reprint author), US Army Res Lab, Energet Mat Sci Branch, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. EM neil.s.weingarten.civ@mail.mil FU Department of Defense (DOD) High Performance Computing Modernization Program (HCPMP) Software Application Institute for Multiscale Reactive Modeling of Insensitive Munitions; DOD HPCMP Challenge award FX This research was supported by the Department of Defense (DOD) High Performance Computing Modernization Program (HCPMP) Software Application Institute for Multiscale Reactive Modeling of Insensitive Munitions and a DOD HPCMP Challenge award. All calculations were performed on the DOD Supercomputer Resource Centers at ARL, ERDC, AFRL, and MHPCC. NR 27 TC 9 Z9 9 U1 2 U2 33 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1549-9618 EI 1549-9626 J9 J CHEM THEORY COMPUT JI J. Chem. Theory Comput. PD FEB PY 2015 VL 11 IS 2 BP 392 EP 405 DI 10.1021/ct5007899 PG 14 WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical SC Chemistry; Physics GA CB9EI UT WOS:000349934400004 PM 26580903 ER PT J AU Elward, JM Chakraborty, A AF Elward, Jennifer M. Chakraborty, Arindam TI Effect of Heterojunction on Exciton Binding Energy and Electron-Hole Recombination Probability in CdSe/ZnS Quantum Dots SO JOURNAL OF CHEMICAL THEORY AND COMPUTATION LA English DT Article ID SENSITIZED SOLAR-CELLS; LIGHT-EMITTING-DIODES; DENSITY-FUNCTIONAL THEORY; CHARGE SEPARATION; MULTIEXCITON GENERATION; HYDROGEN GENERATION; MAGNETIC-FIELDS; SEMICONDUCTOR NANOCRYSTALS; OPTICAL RECTIFICATION; COMPUTATIONAL METHODS AB Presence of heterojunctions is important for generation of free charge carriers and the dissociation of bound electronhole pairs in semiconductor nanoparticles. This work presents a theoretical investigation of the effect of core/shell heterojunction on electronhole interaction in CdSe/ZnS quantum dots. The excitonic wave function in the CdSe/ZnS dots was calculated using the electronhole explicitly correlated HartreeFock (eh-XCHF) method and the effect of successive addition of the ZnS shell on exciton binding energy, electronhole recombination probability, and the electronhole separation distance was investigated. It was found that the scaling of all the three quantities as a function of dot diameter did not follow conventional volume scaling laws of core-only dots, and the scaling laws were significantly altered due to the presence of the heterojunction. The spatial localization of the quasiparticles in the core/shell quantum dot was analyzed by calculating the 1-particle reduced density from the eh-XCHF wave function and partitioning the density spatially into core and shell regions. It was found that in the 15 nm CdSe/ZnS dot, the relative probability of the electron localization in the shell region was higher than the hole by a factor of 3. The degree of spatial localization of the quasiparticles was found to depend strongly on the initial size of the CdSe core in the core/shell quantum dot. It was found that a reduction in the CdSe core diameter by a factor of 1.7 resulted in an enhancement of the preferential localization of the electron in the shell region by a factor of 11.3. The results demonstrate that large CdSe/ZnS quantum dots with a small CdSe core have the necessary characteristics for efficient exciton dissociation and generation of free charge carriers. C1 [Elward, Jennifer M.] Army Res Lab, Aberdeen, MD 21005 USA. [Chakraborty, Arindam] Syracuse Univ, Dept Chem, Syracuse, NY 13244 USA. RP Chakraborty, A (reprint author), Syracuse Univ, Dept Chem, Syracuse, NY 13244 USA. EM archakra@syr.edu FU Syracuse University; National Science Foundation (NSF) CAREER [CHE-1349892]; National Science Foundation [ACI-1053575] FX We gratefully acknowledge financial support from Syracuse University and National Science Foundation (NSF) CAREER Award CHE-1349892. This work also used the Extreme Science and Engineering Discovery Environment (XSEDE), which is supported by National Science Foundation grant number ACI-1053575. NR 138 TC 4 Z9 4 U1 5 U2 30 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1549-9618 EI 1549-9626 J9 J CHEM THEORY COMPUT JI J. Chem. Theory Comput. PD FEB PY 2015 VL 11 IS 2 BP 462 EP 471 DI 10.1021/ct500548x PG 10 WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical SC Chemistry; Physics GA CB9EI UT WOS:000349934400010 PM 26580906 ER PT J AU Qian, JF Henderson, WA Xu, W Bhattacharya, P Engelhard, M Borodin, O Zhang, JG AF Qian, Jiangfeng Henderson, Wesley A. Xu, Wu Bhattacharya, Priyanka Engelhard, Mark Borodin, Oleg Zhang, Ji-Guang TI High rate and stable cycling of lithium metal anode SO NATURE COMMUNICATIONS LA English DT Article ID ELECTROLYTE-SOLUTIONS; RECHARGEABLE BATTERIES; IONIC LIQUIDS; ELECTROCHEMICAL PROPERTIES; CARBONATE SOLVENTS; APROTIC-SOLVENTS; SALT ELECTROLYTE; PHASE-BEHAVIOR; STABILITY; MECHANISM AB Lithium metal is an ideal battery anode. However, dendrite growth and limited Coulombic efficiency during cycling have prevented its practical application in rechargeable batteries. Herein, we report that the use of highly concentrated electrolytes composed of ether solvents and the lithium bis(fluorosulfonyl) imide salt enables the high-rate cycling of a lithium metal anode at high Coulombic efficiency (up to 99.1%) without dendrite growth. With 4M lithium bis(fluorosulfonyl) imide in 1,2-dimethoxyethane as the electrolyte, a lithium|lithium cell can be cycled at 10mA cm(-2) for more than 6,000 cycles, and a copper|lithium cell can be cycled at 4mA cm(-2) for more than 1,000 cycles with an average Coulombic efficiency of 98.4%. These excellent performances can be attributed to the increased solvent coordination and increased availability of lithium ion concentration in the electrolyte. Further development of this electrolyte may enable practical applications for lithium metal anode in rechargeable batteries. C1 [Qian, Jiangfeng; Henderson, Wesley A.; Xu, Wu; Zhang, Ji-Guang] Joint Ctr Energy Storage Res, Argonne, IL 60439 USA. [Qian, Jiangfeng; Henderson, Wesley A.; Xu, Wu; Bhattacharya, Priyanka; Zhang, Ji-Guang] Pacific NW Natl Lab, Energy & Environm Directorate, Richland, WA 99352 USA. [Engelhard, Mark] Pacific NW Natl Lab, Environm & Mol Sci Lab, Richland, WA 99352 USA. [Borodin, Oleg] US Army Res Lab, Sensor & Elect Devices Directorate, Electrochem Branch, Adelphi, MD 20783 USA. RP Zhang, JG (reprint author), Joint Ctr Energy Storage Res, Argonne, IL 60439 USA. EM jiguang.zhang@pnnl.gov RI Borodin, Oleg/B-6855-2012; OI Borodin, Oleg/0000-0002-9428-5291; Engelhard, Mark/0000-0002-5543-0812; Xu, Wu/0000-0002-2685-8684 FU Joint Center for Energy Storage Research; Energy Innovation Hub - U.S. Department of Energy (DOE), Office of Science, Basic Energy Sciences; DOE's Office of Biological and Environmental Research (BER); Linus Pauling distinguished Postdoctoral Fellowship of PNNL; U.S. Army Research Laboratory; DOE [DE-AC05-76RLO1830] FX This work was supported as part of the Joint Center for Energy Storage Research, an Energy Innovation Hub funded by the U.S. Department of Energy (DOE), Office of Science, Basic Energy Sciences. The SEM and XPS characterizations were conducted in the William R. Wiley Environmental Molecular Sciences Laboratory (EMSL)-a national scientific user facility located at PNNL that is sponsored by the DOE's Office of Biological and Environmental Research (BER). P.B. and O.B. gratefully acknowledged supports from the Linus Pauling distinguished Postdoctoral Fellowship of PNNL and U.S. Army Research Laboratory, respectively. PNNL is operated by Battelle for the DOE under Contract DE-AC05-76RLO1830. We thank Mark Bowden of EMSL for his help on XRD measurement and Dr Masashi Yukitake of Nippon Shokubai for supplying the LiFSI salt without charge. NR 43 TC 123 Z9 123 U1 88 U2 442 PU NATURE PUBLISHING GROUP PI LONDON PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND SN 2041-1723 J9 NAT COMMUN JI Nat. Commun. PD FEB PY 2015 VL 6 AR 6362 DI 10.1038/ncomms7362 PG 9 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA CC4BL UT WOS:000350295600001 PM 25698340 ER PT J AU Patil, RR Turgman-Cohen, S Srogl, J Kiserow, D Genzer, J AF Patil, Rohan R. Turgman-Cohen, Salomon Srogl, Jiri Kiserow, Douglas Genzer, Jan TI Direct Measurement of Molecular Weight and Grafting Density by Controlled and Quantitative Degrafting of Surface-Anchored Poly(methyl methacrylate) SO ACS MACRO LETTERS LA English DT Article ID CONTROLLED RADICAL POLYMERIZATION; COMPUTER-SIMULATION; FLAT SURFACES; BRUSHES; ADSORPTION; BULK; ATRP AB We report on quantitative determination of the molecular weight distribution (MWD) and grafting density (sigma(P)) of polymer assemblies grown by controlled radical polymerization from flat substrates as a function of polymerization time and the ratio between the inhibitor and catalyst species. Specifically, we grow poly(methyl methacrylate) (PMMA) brushes on flat silica-based surfaces by surface-initiated atom transfer radical polymerization (SI-ATRP), cleave the PMMA grafts quantitatively using tetrabutyl ammonium fluoride (TBAF), and analyze their MWD by size exclusion chromatography equipped with a high-sensitivity differential refractive index detector. The polymer growth and degrafting processes are followed by ellipsometry, X-ray photoelectron spectroscopy, and time-of-flight secondary ion mass spectrometry. The sigma(P) is independent of polymerization time and increases with increasing SI-ATRP inhibitor/catalyst ratio. Specifically, sigma(P) increases from 0.48 +/- 0.06 to 0.58 +/- 0.06 chains/nm(2) as the inhibitor/catalyst molar ratio increases from 0 to 0.015, respectively, providing evidence that high inhibitor/catalyst ratio offers better control of the SI-ATRP reaction, by lowering number of terminations, and leading to denser PMMA brush assemblies. C1 [Patil, Rohan R.; Srogl, Jiri; Kiserow, Douglas; Genzer, Jan] N Carolina State Univ, Dept Chem & Biomol Engn, Raleigh, NC 27695 USA. [Turgman-Cohen, Salomon] Kettering Univ, Dept Chem Engn, Flint, MI 48504 USA. [Kiserow, Douglas] US Army Res Off, Res Triangle Pk, NC 27709 USA. RP Genzer, J (reprint author), N Carolina State Univ, Dept Chem & Biomol Engn, Raleigh, NC 27695 USA. EM jan_genzer@ncsu.edu FU National Science Foundation [DMR-0906572]; Army Research Office under Staff Research Program [W911NF-04-D-0003-0016] FX The work was supported by the National Science Foundation (Grant no. DMR-0906572) and the Army Research Office under their Staff Research Program (Grant no. W911NF-04-D-0003-0016). NR 29 TC 7 Z9 7 U1 9 U2 42 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 2161-1653 J9 ACS MACRO LETT JI ACS Macro Lett. PD FEB PY 2015 VL 4 IS 2 BP 251 EP 254 DI 10.1021/mz5007188 PG 4 WC Polymer Science SC Polymer Science GA CB7NM UT WOS:000349814100022 ER PT J AU Fresconi, F Celmins, I Silton, S Costello, M AF Fresconi, Frank Celmins, Ilmars Silton, Sidra Costello, Mark TI High maneuverability projectile flight using low cost components SO AEROSPACE SCIENCE AND TECHNOLOGY LA English DT Article DE Projectile; Guided flight; High maneuverability; Low cost ID MISSILE AUTOPILOT DESIGN; GUIDANCE AB This paper examines the problem of enhancing maneuverability of gun-launched munitions utilizing low cost technologies. Two ideas are proposed for reducing cost: (1) designing algorithms that reduce the sensor or actuator burden, and (2) performing high fidelity modeling and simulation of the entire system with realistic data input. The fundamental theory underpinning guided projectile flight systems, including nonlinear equations of motion for projectile flight, aerodynamic modeling, actuator dynamics, and measurement modeling, is outlined. Manipulation of these nonlinear models into linear system models enables airframe stability investigation and flight control design. A basic framework for low cost guidance, navigation, and control (GNC) of high maneuverability projectiles is formulated. Theory was implemented in simulation and exercised for a guided projectile system. Results support the hypothesis that algorithms can compensate for poor actuator performance and identified critical trade study parameters. Monte Carlo analysis indicated that the cost associated with measurements of a threshold accuracy rather than actuation technologies prescribes guided system performance. Published by Elsevier Masson SAS. C1 [Fresconi, Frank; Celmins, Ilmars; Silton, Sidra] US Army Res Lab, Aberdeen Proving Ground, MD 21015 USA. [Costello, Mark] Georgia Inst Technol, Atlanta, GA 30332 USA. RP Fresconi, F (reprint author), US Army Res Lab, Aberdeen Proving Ground, MD 21015 USA. EM frank.e.fresconi.civ@mail.mil NR 21 TC 3 Z9 3 U1 0 U2 10 PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER PI PARIS PA 23 RUE LINOIS, 75724 PARIS, FRANCE SN 1270-9638 EI 1626-3219 J9 AEROSP SCI TECHNOL JI Aerosp. Sci. Technol. PD FEB PY 2015 VL 41 BP 175 EP 188 DI 10.1016/j.ast.2014.12.007 PG 14 WC Engineering, Aerospace SC Engineering GA CC1AR UT WOS:000350073900021 ER PT J AU Gentili, RJ Bradberry, TJ Oh, H Costanzo, ME Kerick, SE Contreras-Vidal, JL Hatfield, BD AF Gentili, Rodolphe J. Bradberry, Trent J. Oh, Hyuk Costanzo, Michelle E. Kerick, Scott E. Contreras-Vidal, Jose L. Hatfield, Bradley D. TI Evolution of cerebral cortico-cortical communication during visuomotor adaptation to a cognitive-motor executive challenge SO BIOLOGICAL PSYCHOLOGY LA English DT Article DE Cortico-cortical communications; Visuomotor adaptation learning; Frontal executive; Electroencephalography; Arm movement; Frequency bands ID ERROR-RELATED NEGATIVITY; HIGH-RESOLUTION EEG; HEMISPHERIC-SPECIALIZATION; BIMANUAL MOVEMENTS; CORTICAL DYNAMICS; NEURAL EFFICIENCY; SKILLED MARKSMEN; PHASE SYNCHRONY; WORKING-MEMORY; FRONTAL-CORTEX AB Cortical dynamics were examined during a cognitive-motor adaptation task that required inhibition of a familiar motor plan. EEG coherence between the motor planning (Fz) and left hemispheric region was progressively reduced over trials (low-beta, high-beta, gamma bands) along with faster, straighter reaching movements during both planning and execution. The major reduction in coherence (delta, low/high-theta, low/high-alpha bands) between Fz and the left prefrontal region during both movement planning and execution suggests gradual disengagement of frontal executive following its initial role in the suppression of established visuomotor maps. Also, change in the directionality of phase lags (delta, high-alpha, high-beta, gamma bands) reflects a progressive shift from feedback to feedforward motor control. The reduction of cortico-cortical communication, particularly in the frontal region, and the strategic feedback/feedforward mode shift translated as higher quality motor performance. This study extends our understanding of the role of frontal executive beyond purely cognitive tasks to cognitive-motor tasks. (C) 2014 Elsevier B.V. All rights reserved. C1 [Gentili, Rodolphe J.; Oh, Hyuk; Hatfield, Bradley D.] Univ Maryland, Sch Publ Hlth, Dept Kinesiol, College Pk, MD 20742 USA. [Gentili, Rodolphe J.; Oh, Hyuk; Costanzo, Michelle E.; Hatfield, Bradley D.] Univ Maryland, Grad Program Neurosci & Cognit Sci, College Pk, MD 20742 USA. [Gentili, Rodolphe J.] Univ Maryland, Maryland Robot Ctr, College Pk, MD 20742 USA. [Bradberry, Trent J.] Metron Inc, Reston, VA USA. [Kerick, Scott E.] US Army Res Lab, Adelphi, MD USA. [Contreras-Vidal, Jose L.] Univ Houston, Dept Elect & Comp Engn, Lab Noninvas Brain Machine Interface Syst, Houston, TX USA. [Hatfield, Bradley D.] Univ Maryland, Sch Publ Hlth, Ctr Aging, College Pk, MD 20742 USA. RP Gentili, RJ (reprint author), Univ Maryland, Sch Publ Hlth, Dept Kinesiol, Motor Neurosci Lab, Bldg 255, College Pk, MD 20742 USA. EM rodolphe@umd.edu FU La Fondation Motrice, Paris, France FX R.J. Gentili was supported by La Fondation Motrice, Paris, France. NR 74 TC 3 Z9 3 U1 0 U2 8 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0301-0511 EI 1873-6246 J9 BIOL PSYCHOL JI Biol. Psychol. PD FEB PY 2015 VL 105 BP 51 EP 65 DI 10.1016/j.biopsycho.2014.12.003 PG 15 WC Psychology, Biological; Behavioral Sciences; Psychology; Psychology, Experimental SC Psychology; Behavioral Sciences GA CB8WH UT WOS:000349912100006 PM 25530479 ER PT J AU Spieker, EA Sbrocco, T Theim, KR Maurer, D Johnson, D Bryant, E Bakalar, JL Schvey, NA Ress, R Seehusen, D Klein, DA Stice, E Yanovski, JA Chan, L Gentry, S Ellsworth, C Hill, JW Tanofsky-Kraff, M Stephens, MB AF Spieker, Elena A. Sbrocco, Tracy Theim, Kelly R. Maurer, Douglas Johnson, Dawn Bryant, Edny Bakalar, Jennifer L. Schvey, Natasha A. Ress, Rachel Seehusen, Dean Klein, David A. Stice, Eric Yanovski, Jack A. Chan, Linda Gentry, Shari Ellsworth, Carol Hill, Joanne W. Tanofsky-Kraff, Marian Stephens, Mark B. TI Preventing Obesity in the Military Community (POMC): The Development of a Clinical Trials Research Network SO INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH LA English DT Article ID RANDOMIZED EFFICACY TRIAL; EATING-DISORDER; ADULT OBESITY; INTERPERSONAL PSYCHOTHERAPY; DESERT-STORM; HIGH-RISK; METABOLIC SYNDROME; ADOLESCENT GIRLS; WEIGHT-GAIN; BODY-WEIGHT AB Obesity impacts the U.S. military by affecting the health and readiness of active duty service members and their families. Preventing Obesity in Military Communities (POMC) is a comprehensive research program within Patient Centered Medical Homes (PCMHs) in three Military Training Facilities. This paper describes three pilot randomized controlled trials that target critical high risk periods for unhealthy weight gain from birth to young adulthood: (1) pregnancy and early infancy (POMC-Mother-Baby), (2) adolescence (POMC-Adolescent), and (3) the first tour of duty after boot camp (POMC-Early Career). Each study employs a two-group randomized treatment or prevention program with follow up. POMC offers a unique opportunity to bring together research and clinical expertise in obesity prevention to develop state-of-the-art programs within PCMHs in Military Training Facilities. This research builds on existing infrastructure that is expected to have immediate clinical benefits to DoD and far-reaching potential for ongoing collaborative work. POMC may offer an economical approach for widespread obesity prevention, from conception to young adulthood, in the U.S. military as well as in civilian communities. C1 [Spieker, Elena A.; Maurer, Douglas] Madigan Army Med Ctr, Dept Family Med, Tacoma, WA 98431 USA. [Spieker, Elena A.; Sbrocco, Tracy; Theim, Kelly R.; Johnson, Dawn; Bryant, Edny; Bakalar, Jennifer L.; Schvey, Natasha A.; Ress, Rachel; Tanofsky-Kraff, Marian] Uniformed Serv Univ Hlth Sci, Dept Med & Clin Psychol, Bethesda, MD 20814 USA. [Spieker, Elena A.; Theim, Kelly R.; Bakalar, Jennifer L.; Schvey, Natasha A.; Ress, Rachel] Henry M Jackson Fdn Adv Mil Med Inc, Bethesda, MD 20817 USA. [Seehusen, Dean] Dept Family & Community Med, Ft Gordon, GA 30905 USA. [Klein, David A.] Ft Belvoir Community Hosp, Dept Family Med, Ft Belvoir, VA 22060 USA. [Stice, Eric] Oregon Res Inst, Eugene, OR 97403 USA. [Yanovski, Jack A.; Tanofsky-Kraff, Marian] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Sect Growth & Obes, Program Dev Endocrinol & Genet, NIH,DHHS, Bethesda, MD 20892 USA. [Chan, Linda] Naval Hosp Camp Lejeune, Dept Obstet & Gynecol, Camp Lejeune, NC 28547 USA. [Gentry, Shari; Ellsworth, Carol] Naval Hosp Camp Lejeune, Dept Family Med, Camp Lejeune, NC 28547 USA. [Hill, Joanne W.] Naval Hosp Camp Lejeune, Dept Res, Camp Lejeune, NC 28547 USA. [Stephens, Mark B.] Uniformed Serv Univ Hlth Sci, Dept Family Med, Bethesda, MD 20814 USA. RP Sbrocco, T (reprint author), Uniformed Serv Univ Hlth Sci, Dept Med & Clin Psychol, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA. EM elena.a.spieker.ctr@mail.mil; tracy.sbrocco@usuhs.edu; kelly.theim.ctr@usuhs.edu; douglas.m.maurer.mil@mail.mil; dawn.johnson@usuhs.edu; edny.joseph@usuhs.edu; Jennifer.bakalar@usuhs.edu; natasha.schvey.ctr@usuhs.edu; rachel.ress.ctr@usuhs.edu; Dean.A.Seehusen.mil@health.mil; david.a.klein26.mil@mail.mil; estice@ori.org; yanovskj@mail.nih.gov; Linda.Chan@med.navy.mil; shari.gentry@med.navy.mil; carol.ellsworth@med.navy.mil; Joanne.Hill@med.navy.mil; marian.tanofsky-kraff@usuhs.edu; mark.stephens@usuhs.edu OI Yanovski, Jack/0000-0001-8542-1637 FU Uniformed Services University [USUHS72NC-01]; NICHD [Z1aHD00641]; [F172NC-02] FX Research support provided by a grant from the Uniformed Services University (USUHS72NC-01) to Tracy Sbrocco and intramural support from NICHD (Z1aHD00641) to Jack A. Yanovski, a Commissioned Officer in the United States Public Health Service. This manuscript was developed within the scope of work for the Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., by authors Elena A. Spieker, Kelly R. Theim supported by grant F172NC-02. NR 57 TC 3 Z9 3 U1 2 U2 5 PU MDPI AG PI BASEL PA POSTFACH, CH-4005 BASEL, SWITZERLAND SN 1660-4601 J9 INT J ENV RES PUB HE JI Int. J. Environ. Res. Public Health PD FEB PY 2015 VL 12 IS 2 BP 1174 EP 1195 DI 10.3390/ijerph120201174 PG 22 WC Environmental Sciences; Public, Environmental & Occupational Health SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health GA CC2XZ UT WOS:000350209800008 PM 25648176 ER PT J AU Camacho, M Zaghi, S Certal, V Abdullatif, J Means, C Acevedo, J Liu, S Brietzke, SE Kushida, CA Capasso, R AF Camacho, Macario Zaghi, Soroush Certal, Victor Abdullatif, Jose Means, Casey Acevedo, Jason Liu, Stanley Brietzke, Scott E. Kushida, Clete A. Capasso, Robson TI Inferior Turbinate Classification System, Grades 1 to 4: Development and Validation Study SO LARYNGOSCOPE LA English DT Article DE Turbinates; classification; nose; validation; hypertrophy ID OBSTRUCTIVE SLEEP-APNEA; TONSILLAR SIZE; REDUCTION; KAPPA; HYPERTROPHY; AGREEMENT AB Objectives/Hypothesis: To develop a validated inferior turbinate grading scale. Study Design: Development and validation study. Methods: Phase 1 development (alpha test) consisted of a proposal of 10 different inferior turbinate grading scales (>1,000 clinic patients). Phase 2 validation (beta test) utilized 10 providers grading 27 standardized endoscopic photos of inferior turbinates using two different classification systems. Phase 3 validation (pilot study) consisted of 100 live consecutive clinic patients (n=200 inferior turbinates) who were each prospectively graded by 18 different combinations of two independent raters, and grading was repeated by each of the same two raters, two separate times for each patient. Results: In the development phase, 25% (grades 1-4) and 33% (grades 1-4) were the most useful systems. In the validation phase, the 25% classification system was found to be the best balance between potential clinical utility and ability to grade; the photo grading demonstrated a Cohen's kappa (kappa) = 0.4671 +/- 0.0082 (moderate inter-rater agreement). Live-patient grading with the 25% classification system demonstrated an overall inter-rater reliability of 71.5% (95% confidence interval [CI]: 64.8-77.3), with overall substantial agreement (kappa = 0.704 +/- 0.028). Intrarater reliability was 91.5% (95% CI: 88.7-94.3). Distribution for the 200 inferior turbinates was as follows: 25% quartile = grade 1, 50% quartile (median) = grade 2, 75% quartile = grade 3, and 90% quartile = grade 4. Mean turbinate size was 2.22 (95% CI: 2.07-2.34; standard deviation 1.02). Categorical kappa was as follows: grade 1, 0.8541 +/- 0.0289; grade 2, 0.7310 +/- 0.0289; grade 3, 0.6997 +/- 0.0289, and grade 4, 0.7760 +/- 0.0289. Conclusions: The 25% (grades 1-4) inferior turbinate classification system is a validated grading scale with high intra-rater and inter-rater reliability. This system can facilitate future research by tracking the effect of interventions on inferior turbinates. C1 [Camacho, Macario] Stanford Outpatient Med Ctr, Sleep Med Div, Dept Psychiat, Redwood City, CA USA. [Zaghi, Soroush] Univ Calif Los Angeles, Dept Head & Neck Surg, Los Angeles, CA USA. [Certal, Victor] Hosp Lusiadas, Dept Otorhinolaryngol, Oporto, Portugal. [Certal, Victor] Univ Porto, CINTESIS Ctr Res Hlth Technol & Informat Syst, P-4100 Oporto, Portugal. [Abdullatif, Jose] Hosp Bernardino Rivadavia, Dept Otorhinolaryngol, Buenos Aires, DF, Argentina. [Means, Casey] Stanford Sch Med, Stanford, CA USA. [Abdullatif, Jose] Reynolds Army Community Hosp, Ft Sill, OK USA. [Liu, Stanley] Stanford Univ, Med Ctr, Sleep Surg Div, Dept Otolaryngol Head & Neck Surg, Stanford, CA 94305 USA. [Brietzke, Scott E.] Walter Reed Natl Mil Med Ctr, Dept Otolaryngol Head & Neck Surg, Bethesda, MD USA. [Kushida, Clete A.] Stanford Hosp & Clin, Div Sleep Med, Dept Psychiat, Redwood City, CA 94063 USA. [Capasso, Robson] Stanford Univ, Med Ctr, Sleep Surg Div, Dept Otolaryngol Head & Neck Surg, Stanford, CA 94305 USA. RP Camacho, M (reprint author), Stanford Hosp & Clin, Stanford Outpatient Med Ctr, Sleep Med Div, Dept Psychiat, 2nd Floor,450 Broadway St, Redwood City, CA 94063 USA. EM drcamachoent@yahoo.com RI FMUP, CINTESIS/C-6631-2014; OI FMUP, CINTESIS/0000-0001-7248-2086; Certal, Victor/0000-0002-1904-9504; Camacho, Macario/0000-0001-9200-9085 NR 22 TC 14 Z9 14 U1 0 U2 1 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0023-852X EI 1531-4995 J9 LARYNGOSCOPE JI Laryngoscope PD FEB PY 2015 VL 125 IS 2 BP 296 EP 302 DI 10.1002/lary.24923 PG 7 WC Medicine, Research & Experimental; Otorhinolaryngology SC Research & Experimental Medicine; Otorhinolaryngology GA CB9SS UT WOS:000349973400016 PM 25215619 ER PT J AU Baldwin, KM Ehrenberg, PK Geretz, A Prentice, HA Nitayaphan, S Rerks-Ngarm, S Kaewkungwal, J Pitisuttithum, P O'Connell, RJ Kim, JH Thomas, R AF Baldwin, K. M. Ehrenberg, P. K. Geretz, A. Prentice, H. A. Nitayaphan, S. Rerks-Ngarm, S. Kaewkungwal, J. Pitisuttithum, P. O'Connell, R. J. Kim, J. H. Thomas, R. TI HLA class II diversity in HIV-1 uninfected individuals from the placebo arm of the RV144 Thai vaccine efficacy trial SO TISSUE ANTIGENS LA English DT Article DE HIV-1; Human leukocyte antigen; HLA-DPB1; HLA-DQB1; HLA-DRB1; RV144 ID HAPLOTYPE FREQUENCIES; ANTIBODY-RESPONSE; ALLELES; POPULATION; HLA-DRB1; ANTIGEN; POLYMORPHISM; MOLECULES; INFECTION; GENES AB The RV144 HIV vaccine trial in Thailand elicited antibody responses to the envelope of HIV-1, which correlated significantly with the risk of HIV-1 acquisition. Human leukocyte antigen (HLA) class II molecules are essential in antigen presentation to CD4 T cells for activation of B cells to produce antibodies. We genotyped the classical HLA-DRB1, DQB1, and DPB1 genes in 450 individuals from the placebo arm of the RV144 study to determine the background allele and haplotype frequencies of these genes in this cohort. High-resolution 4 and 6-digit class II HLA typing data was generated using sequencing-based methods. The observed diversity for the HLA loci was 33 HLA-DRB1, 15 HLA-DQB1, and 26 HLA-DPB1 alleles. Common alleles with frequencies greater than 10% were DRB1*07:01, DRB1*09:01, DRB1*12:02, DRB1*15:02, DQB1*02:01/02, DQB1*03:01, DQB1*03:03, DQB1*05:01, DQB1*05:02, DPB1*04:01:01, DPB1*05:01:01, and DPB1*13:01:01. We identified 28 rare alleles with frequencies of less than 1% in the Thai individuals. Ambiguity for HLA-DPB1*28:01 in exon 2 was resolved to DPB1*296:01 by next-generation sequencing of all exons. Multi-locus haplotypes including HLA class I and II loci were reported in this study. This is the first comprehensive report of allele and haplotype frequencies of all three HLA class II genes from a Thai population. A high-resolution genotyping method such as next-generation sequencing avoids missing rare alleles and resolves ambiguous calls. The HLA class II genotyping data generated in this study will be beneficial not only for future disease association/vaccine efficacy studies related to the RV144 study, but also for similar studies in other diseases in the Thai population, as well as population genetics and transplantation studies. C1 [Baldwin, K. M.; Ehrenberg, P. K.; Geretz, A.; Kim, J. H.; Thomas, R.] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD 20910 USA. [Baldwin, K. M.; Geretz, A.; Prentice, H. A.; Thomas, R.] Henry M Jackson Fdn Adv Mil Med, Bethesda, MD USA. [Nitayaphan, S.; O'Connell, R. J.] AFRIMS, US Army Med Component, Dept Retrovirol, Bangkok, Thailand. [Rerks-Ngarm, S.] Minist Publ Hlth, Dept Dis Control, Nonthaburi, Thailand. [Kaewkungwal, J.] Mahidol Univ, Fac Trop Med, Ctr Excellence Biomed & Publ Hlth Informat BIOPHI, Bangkok, Thailand. [Pitisuttithum, P.] Mahidol Univ, Fac Trop Med, Vaccine Trials Ctr, Bangkok, Thailand. RP Thomas, R (reprint author), Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD 20910 USA. EM rthomas@hivresearch.org FU Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. [W81XWH-07-2-0067]; U.S. Department of Defense (DOD) [W81XWH-07-2-0067]; U.S. National Institute of Allergy and Infectious Disease FX This work was supported by a cooperative agreement (W81XWH-07-2-0067) between the Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., and the U.S. Department of Defense (DOD). This research was funded, in part, by the U.S. National Institute of Allergy and Infectious Disease. The views expressed are those of the authors and should not be construed to represent the positions of the U.S. Army or the DOD. We would like to thank Dr. Richard Apps (NCI-Frederick) for the helpful comments. NR 31 TC 2 Z9 2 U1 0 U2 3 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0001-2815 EI 1399-0039 J9 TISSUE ANTIGENS JI Tissue Antigens PD FEB PY 2015 VL 85 IS 2 BP 117 EP 126 DI 10.1111/tan.12507 PG 10 WC Cell Biology; Immunology; Pathology SC Cell Biology; Immunology; Pathology GA CA6OH UT WOS:000349033700005 PM 25626602 ER PT J AU Eichfeld, SM Hossain, L Lin, YC Piasecki, AF Kupp, B Birdwell, AG Burke, RA Lu, N Peng, X Li, J Azcatl, A McDonnell, S Wallace, RM Kim, MJ Mayer, TS Redwing, JM Robinson, JA AF Eichfeld, Sarah M. Hossain, Lorraine Lin, Yu-Chuan Piasecki, Aleksander F. Kupp, Benjamin Birdwell, A. Glen Burke, Robert A. Lu, Ning Peng, Xin Li, Jie Azcatl, Angelica McDonnell, Stephen Wallace, Robert M. Kim, Moon J. Mayer, Theresa S. Redwing, Joan M. Robinson, Joshua A. TI Highly Scalable, Atomically Thin WSe2 Grown via Metal-Organic Chemical Vapor Deposition SO ACS NANO LA English DT Article DE tungsten diselenide; WSe2; metal organic chemical vapor deposition (MOCVD); transition-metal dichalcogenide; graphene; synthesis; two-dimensional (2D) materials ID SINGLE-LAYER; TUNGSTEN DISELENIDE; MONOLAYER MOS2; FILMS; WS2; HETEROSTRUCTURES; SHEETS; MONO; DICHALCOGENIDES; DISULFIDES AB Tungsten diselenide (WSe2) is a two-dimensional material that is of interest for next-generation electronic and optoelectronic devices due to its direct bandgap of 1.65 eV in the monolayer form and excellent transport properties. However, technologies based on this 2D material cannot be realized without a scalable synthesis process. Here, we demonstrate the first scalable synthesis of large-area, mono and few-layer WSe2 via metalorganic chemical vapor deposition using tungsten hexacarbonyl (W(CO)(6)) and dimethylselenium ((CH3)(2)Se). In addition to being intrinsically scalable, this technique allows for the precise control of the vapor-phase chemistry, which is unobtainable using more traditional oxide vaporization routes. We show that temperature, pressure, Se:W ratio, and substrate choice have a strong impact on the ensuing atomic layer structure, with optimized conditions yielding >8 mu m size domains. Raman spectroscopy, atomic force microscopy (AFM), and cross-sectional transmission electron microscopy (TEM) confirm crystalline monoto-multilayer WSe2 is achievable. Finally, TEM and vertical current/voltage transport provide evidence that a pristine van der Waals gap exists in WSe2/graphene heterostructures. C1 [Eichfeld, Sarah M.; Hossain, Lorraine; Lin, Yu-Chuan; Piasecki, Aleksander F.; Kupp, Benjamin; Redwing, Joan M.; Robinson, Joshua A.] Penn State Univ, Dept Mat Sci & Engn, University Pk, PA 16802 USA. [Eichfeld, Sarah M.; Hossain, Lorraine; Lin, Yu-Chuan; Piasecki, Aleksander F.; Kupp, Benjamin; Mayer, Theresa S.; Redwing, Joan M.; Robinson, Joshua A.] Penn State Univ, Ctr Two Dimens & Layered Mat, University Pk, PA 16802 USA. [Li, Jie; Mayer, Theresa S.] Penn State Univ, Dept Elect Engn, University Pk, PA 16802 USA. [Lu, Ning; Peng, Xin; Azcatl, Angelica; McDonnell, Stephen; Wallace, Robert M.; Kim, Moon J.] Univ Texas Dallas, Dept Mat Sci & Engn, Richardson, TX 75080 USA. [Birdwell, A. Glen; Burke, Robert A.] US Army Res Lab, Adelphi, MD 20783 USA. RP Robinson, JA (reprint author), Penn State Univ, Dept Mat Sci & Engn, University Pk, PA 16802 USA. EM jrobinson@psu.edu RI Lu, Ning/H-2351-2012; McDonnell, Stephen/E-1868-2011; Kim, Moon/A-2297-2010; Wallace, Robert/A-5283-2008 OI McDonnell, Stephen/0000-0001-9173-2060; Wallace, Robert/0000-0001-5566-4806 FU Center for Low Energy Systems Technology (LEAST), one of six centers - STARnet phase of the Focus Center Research Program (FCRP); Semiconductor Research Corporation (SRC) program - MARCO; DARPA; Southwest Academy on Nanoelectronics (SWAN); SRC center - Nanoelectronics Research Initiative; NIST; National Science Foundation [ECS-0335765] FX We thank N. R. Glavin and A. A. Voevodin of the Nanoelectronic Materials Branch, Air Force Research Laboratory, Wright-Patterson AFB, Dayton, OH, for providing BN/sapphire substrates for synthesis. The work at Penn State and UT Dallas was supported by the Center for Low Energy Systems Technology (LEAST), one of six centers supported by the STARnet phase of the Focus Center Research Program (FCRP), a Semiconductor Research Corporation (SRC) program sponsored by MARCO and DARPA. Work at UT Dallas was also supported by the Southwest Academy on Nanoelectronics (SWAN), a SRC center sponsored by the Nanoelectronics Research Initiative and NIST. The work at the U.S. Army Research Laboratory (ARL) was supported by the Director's Strategic Initiative (DSI) program on interfaces in stacked 2D atomic layered materials. Device fabrication was partially supported by the Pennsylvania State University Materials Research Institute Nanofabrication Laboratory and the National Science Foundation Cooperative Agreement No. ECS-0335765. NR 49 TC 41 Z9 41 U1 26 U2 226 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1936-0851 EI 1936-086X J9 ACS NANO JI ACS Nano PD FEB PY 2015 VL 9 IS 2 BP 2080 EP 2087 DI 10.1021/nn5073286 PG 8 WC Chemistry, Multidisciplinary; Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary SC Chemistry; Science & Technology - Other Topics; Materials Science GA CB9GR UT WOS:000349940500104 PM 25625184 ER PT J AU Ranade, R Li, VC Heard, WF AF Ranade, Ravi Li, Victor C. Heard, William F. TI Tensile Rate Effects in High Strength-High Ductility Concrete SO CEMENT AND CONCRETE RESEARCH LA English DT Article DE Strain effect; Mechanical properties; Micromechanics; High-performance concrete; Composite ID ENGINEERED CEMENTITIOUS COMPOSITES; STRAIN-RATE; COMPRESSIVE BEHAVIOR; FRACTURE; IMPACT; MODEL AB Researchers at the University of Michigan have recently developed a new class of concrete, named High Strength-High Ductility Concrete (HSHDC), which possesses exceptional combination of compressive strength (>150 MPa) and tensile ductility (>3%) under quasi-static loads. The structural applications of HSHDC for withstanding extreme events, such as hurricanes, earthquakes, impacts, and blasts, require an understanding of its dynamic behavior at high strain rates. This research experimentally investigates the effects of strain rate (from 10(-4)/s to 10/s) on the composite tensile properties and the micro-scale fiber/matrix interaction properties of HSHDC. A micromechanics-based scale-linking model is used to analytically explain the composite-scale rate effects based on the micro-scale rate effects. Due to the unique interactions between the Polyethylene fibers and densely packed ultra-high strength matrix of HSHDC, novel rate effects are revealed, which are expected to be foundational for the future development of this class of materials for improving infrastructure resilience. (C) 2014 Elsevier Ltd. All rights reserved. C1 [Ranade, Ravi] SUNY Buffalo, Dept Civil Struct & Environm Engn, Inst Bridge Engn, Buffalo, NY 14260 USA. [Li, Victor C.] Univ Michigan, Dept Civil & Environm Engn, Ann Arbor, MI 48109 USA. [Heard, William F.] US Army, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Li, VC (reprint author), Univ Michigan, Dept Civil & Environm Engn, 2350 Hayward St, Ann Arbor, MI 48109 USA. EM vcli@umich.edu RI Ranade, Ravi/I-6387-2013; OI Ranade, Ravi/0000-0001-6030-8371; Li, Victor/0000-0002-8678-3493 FU U.S. Army ERDC, Vicksburg, MS [W912HZ-08-C-0056] FX This research at the University of Michigan was supported by a research contract (W912HZ-08-C-0056) from the U.S. Army ERDC, Vicksburg, MS. Helpful discussions with T. Rushing, T. Slawson, B. Williams, and J. Davis of ERDC are gratefully acknowledged. The authors also acknowledge the material suppliers Honeywell, Lafarge, US Silica, Elkem, and WR Grace, for providing materials for this research. Permission to publish was granted by the Director, Geotechnical and Structures Laboratory at ERDC. NR 46 TC 6 Z9 6 U1 8 U2 35 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0008-8846 EI 1873-3948 J9 CEMENT CONCRETE RES JI Cem. Concr. Res. PD FEB PY 2015 VL 68 BP 94 EP 104 DI 10.1016/j.cemconres.2014.11.005 PG 11 WC Construction & Building Technology; Materials Science, Multidisciplinary SC Construction & Building Technology; Materials Science GA CB4BE UT WOS:000349572400009 ER PT J AU Ouedraogo, AL Bastiaens, GJH Tiono, AB Guelbeogo, WM Kobylinski, KC Ouedraogo, A Barry, A Bougouma, EC Nebie, I San Ouattara, M Lanke, KHW Fleckenstein, L Sauerwein, RW Slater, HC Churcher, TS Sirima, SB Drakeley, C Bousema, T AF Ouedraogo, Andre Lin Bastiaens, Guido J. H. Tiono, Alfred B. Guelbeogo, Wamdaogo M. Kobylinski, Kevin C. Ouedraogo, Alphonse Barry, Aissata Bougouma, Edith C. Nebie, Issa San Ouattara, Maurice Lanke, Kjerstin H. W. Fleckenstein, Lawrence Sauerwein, Robert W. Slater, Hannah C. Churcher, Thomas S. Sirima, Sodiomon B. Drakeley, Chris Bousema, Teun TI Efficacy and Safety of the Mosquitocidal Drug Ivermectin to Prevent Malaria Transmission After Treatment: A Double-Blind, Randomized, Clinical Trial SO CLINICAL INFECTIOUS DISEASES LA English DT Article DE falciparum; gametocyte; transmission; survivorship; sporogony ID PLASMODIUM-FALCIPARUM MALARIA; ARTEMETHER-LUMEFANTRINE; MASS TREATMENT; ONCHOCERCIASIS; PRIMAQUINE; CHILDREN; PLASMA; ASSAY AB Background. Artemisinin combination therapy effectively clears asexual malaria parasites and immature gametocytes but does not prevent posttreatment malaria transmission. Ivermectin (IVM) may reduce malaria transmission by killing mosquitoes that take blood meals from IVM-treated humans. Methods. In this double-blind, placebo-controlled trial, 120 asymptomatic Plasmodium falciparum parasite carriers were randomized to receive artemether-lumefantrine (AL) plus placebo or AL plus a single or repeated dose (200 mu g/kg) of ivermectin (AL-IVM1 and AL-IVM2, respectively). Mosquito membrane feeding was performed 1, 3, and 7 days after initiation of treatment to determine Anopheles gambiae and Anopheles funestus survival and infection rates. Results. The AL-IVM combination was well tolerated. IVM resulted in a 4- to 7-fold increased mortality in mosquitoes feeding 1 day after IVM(P < .001). Day 7 IVM plasma levels were positively associated with body mass index (r = 0.57, P < .001) and were higher in female participants (P = .003), for whom An. gambiae mosquito mortality was increased until 7 days after a single dose of IVM (hazard rate ratio, 1.34 [95% confidence interval, 1.07-1.69]; P = .012). Although we found no evidence that IVM reduced Plasmodium infection rates among surviving mosquitoes, the mosquitocidal effect of AL-IVM1 and AL-IVM2 resulted in 27% and 35% reductions, respectively, in estimated malaria transmission potential during the first week after initiation of treatment. Conclusions. We conclude that IVM can be safely given in combination with AL and can reduce the likelihood of malaria transmission by reducing the life span of feeding mosquitoes. C1 [Ouedraogo, Andre Lin; Tiono, Alfred B.; Guelbeogo, Wamdaogo M.; Ouedraogo, Alphonse; Barry, Aissata; Bougouma, Edith C.; Nebie, Issa; San Ouattara, Maurice; Sirima, Sodiomon B.] Ctr Natl Rech & Format Paludisme, Dept Biomed Sci, Ouagadougou, Burkina Faso. [Bastiaens, Guido J. H.; Lanke, Kjerstin H. W.; Sauerwein, Robert W.; Bousema, Teun] Radboud Univ Nijmegen Med Ctr, Dept Med Microbiol, NL-6500 HB Nijmegen, Netherlands. [Kobylinski, Kevin C.] Walter Reed Army Inst Res, Entomol Branch, Silver Spring, MD USA. [Kobylinski, Kevin C.] Armed Forces Res Inst Med Sci, Entomol Dept, Bangkok 10400, Thailand. [Fleckenstein, Lawrence] Univ Iowa, Coll Pharm, Iowa City, IA 52242 USA. [Slater, Hannah C.; Churcher, Thomas S.] Univ London Imperial Coll Sci Technol & Med, MRC Ctr Outbreak Anal & Modelling, London SW7 2AZ, England. [Drakeley, Chris; Bousema, Teun] London Sch Hyg & Trop Med, Dept Immunol & Infect, London, England. RP Bousema, T (reprint author), Radboud Univ Nijmegen Med Ctr, Dept Med Microbiol, Geert Grootepl Zuid 26-28, NL-6500 HB Nijmegen, Netherlands. EM teun.bousema@radboudumc.nl RI Sauerwein, Robert/C-8519-2013; Bousema, Teun/N-3574-2014; Bastiaens, Guido/P-6642-2015; OI Slater, Hannah/0000-0003-4291-7899; Churcher, Thomas/0000-0002-8442-0525 FU Bill & Melinda Gates Foundation [OPP1034789]; Radboud University Medical Center FX This work was supported by the Bill & Melinda Gates Foundation (grant number OPP1034789) and by the Radboud University Medical Center (Radboud Hypatia Track). Novartis provided the artemether-lumefantrine. NR 27 TC 13 Z9 13 U1 3 U2 7 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 1058-4838 EI 1537-6591 J9 CLIN INFECT DIS JI Clin. Infect. Dis. PD FEB 1 PY 2015 VL 60 IS 3 BP 357 EP 365 DI 10.1093/cid/ciu797 PG 9 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA CB6UG UT WOS:000349761600013 PM 25414262 ER PT J AU Casali, JG Robinette, MB AF Casali, John G. Robinette, Martin B. TI Effects of user training with electronically-modulated sound transmission hearing protectors and the open ear on horizontal localization ability SO INTERNATIONAL JOURNAL OF AUDIOLOGY LA English DT Article DE Auditory learning; sensory adaptation; localization; hearing protection; electronically modulated; warfighter; interaural level differences; interaural time differences; TCAPS; active HPDs ID ADAPTATION; COORDINATION; FIELD AB Objective: To determine if training with electronically-modulated hearing protection (EMHP) and the open ear results in auditory learning on a horizontal localization task. Design: Baseline localization testing was conducted in three listening conditions (open-ear, in-the-ear (ITE) EMHP, and over-the-ear (OTE) EMHP). Participants then wore either an ITE or OTE EMHP for 12, almost daily, one-hour training sessions. After training was complete, participants again underwent localization testing in all three listening conditions. A computer with a custom software and hardware interface presented localization sounds and collected participant responses. Study sample: Twelve participants were recruited from the student population at Virginia Tech. Audiometric requirements were 35 dBHL at 500, 1000, and 2000 Hz bilaterally, and 55 dBHL at 4000 Hz in at least one ear. Results: Pre-training localization performance with an ITE or OTE EMHP was worse than open-ear performance. After training with any given listening condition, including open-ear, performance in that listening condition improved, in part from a practice effect. However, post-training localization performance showed near equal performance between the open-ear and training EMHP. Auditory learning occurred for the training EMHP, but not for the non-training EMHP; that is, there was no significant training crossover effect between the ITE and the OTE devices. Conclusion: It is evident from this study that auditory learning (improved horizontal localization performance) occurred with the EMHP for which training was performed. However, performance improvements found with the training EMHP were not realized in the non-training EMHP. Furthermore, localization performance in the open-ear condition also benefitted from training on the task. C1 [Casali, John G.] Virginia Polytech Inst & State Univ, Auditory Syst Lab, Virginia Tech, Blacksburg, VA 24061 USA. [Robinette, Martin B.] US Army Publ Hlth Command, Aberdeen Proving Ground, MD USA. RP Casali, JG (reprint author), Virginia Tech, Auditory Syst Lab, 250 Durham Hall, Blacksburg, VA 24061 USA. EM jcasali@exchange.vt.edu FU Office of Naval Research FX The authors are grateful for the funding provided by the Office of Naval Research, Kurt Yankaskas, Contract Technical Officer, and to Doug Brungart of Walter Reed National Military Medical Center, for technical assistance. NR 21 TC 2 Z9 2 U1 0 U2 1 PU INFORMA HEALTHCARE PI LONDON PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND SN 1499-2027 EI 1708-8186 J9 INT J AUDIOL JI Int. J. Audiol. PD FEB PY 2015 VL 54 SU 1 BP S37 EP S45 DI 10.3109/14992027.2014.973538 PG 9 WC Audiology & Speech-Language Pathology; Otorhinolaryngology SC Audiology & Speech-Language Pathology; Otorhinolaryngology GA CB5MF UT WOS:000349670800006 PM 25549166 ER PT J AU Fresconi, F Rogers, J AF Fresconi, Frank Rogers, Jonathan TI Flight Control of a Small-Diameter Spin-Stabilized Projectile Using Imager Feedback SO JOURNAL OF GUIDANCE CONTROL AND DYNAMICS LA English DT Article ID ORIENTATION ESTIMATOR; GUIDANCE; MISSILE; SENSORS AB Small-diameter gun-launched projectiles pose a challenging platform on which to implement closed-loop guidance and control. This paper presents a novel imager-based guidance and control algorithm for small-diameter spin-stabilized projectiles. The control law is specifically formulated to rely on feedback only from a strapdown detector and roll angle sensors. Following introduction of the projectile nonlinear dynamic model, an integrated guidance and control algorithm is presented in which control commands are computed directly from detector feedback using a gain-scheduled proportional control. Time-varying controller gains are derived through a surrogate modeling approach, and controller performance is further enhanced through use of an observer that filters unwanted angular motion components from detector feedback. Example closed-loop flight simulations demonstrate performance of the proposed control system, and MonteCarlo analysis shows a factor of 2 accuracy improvement for the closed-loop system over ballistic flight. Results indicate that delivery system improvements are achievable in small, gyroscopically stabilized projectiles containing low-cost guidance elements using the proposed integrated guidance and control approach. C1 S Army Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. Georgia Inst Technol, Sch Mech Engn, Atlanta, GA 30332 USA. [Fresconi, Frank] US Army Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. [Rogers, Jonathan] Georgia Inst Technol, Sch Mech Engn, Atlanta, GA 30332 USA. RP Fresconi, F (reprint author), US Army Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. NR 34 TC 0 Z9 1 U1 3 U2 15 PU AMER INST AERONAUTICS ASTRONAUTICS PI RESTON PA 1801 ALEXANDER BELL DRIVE, STE 500, RESTON, VA 22091-4344 USA SN 0731-5090 EI 1533-3884 J9 J GUID CONTROL DYNAM JI J. Guid. Control Dyn. PD FEB PY 2015 VL 38 IS 2 BP 181 EP 191 DI 10.2514/1.G000815 PG 11 WC Engineering, Aerospace; Instruments & Instrumentation SC Engineering; Instruments & Instrumentation GA CB1DW UT WOS:000349368000001 ER PT J AU Klett, H Rodriguez-Fernandez, M Dineen, S Leon, LR Timmer, J Doyle, FJ AF Klett, Hagen Rodriguez-Fernandez, Maria Dineen, Shauna Leon, Lisa R. Timmer, Jens Doyle, Francis J., III TI Modeling the inflammatory response in the hypothalamus ensuing heat stroke: Iterative cycle of model calibration, identifiability analysis, experimental design and data collection SO MATHEMATICAL BIOSCIENCES LA English DT Article DE Heat stroke; Hypothalamus; Mathematical modeling; Optimal experimental design; Bayesian ID TUMOR-NECROSIS-FACTOR; FACTOR-ALPHA; INTERLEUKIN-6; EXPRESSION; FEVER; ACTIVATION; MECHANISMS; CYTOKINES; BIOLOGY; SYSTEMS AB Heat Stroke (HS) is a life-threatening illness caused by prolonged exposure to heat that causes severe hyperthermia and nervous system abnormalities. The long term consequences of HS are poorly understood and deeper insight is required to find possible treatment strategies. Elevated pro- and anti-inflammatory cytokines during HS recovery suggest to play a major role in the immune response. In this study, we developed a mathematical model to understand the interactions and dynamics of cytokines in the hypothalamus, the main thermoregulatory center in the brain. Uncertainty and identifiability analysis of the calibrated model parameters revealed non-identifiable parameters due to the limited amount of data. To overcome the lack of identifiability of the parameters, an iterative cycle of optimal experimental design, data collection, re-calibration and model reduction was applied and further informative experiments were suggested. Additionally, a new method of approximating the prior distribution of the parameters for Bayesian optimal experimental design based on the profile likelihood is presented. (C) 2014 Elsevier Inc. All rights reserved. C1 [Klett, Hagen; Rodriguez-Fernandez, Maria; Doyle, Francis J., III] Univ Calif Santa Barbara, Dept Chem Engn, Santa Barbara, CA 93106 USA. [Dineen, Shauna; Leon, Lisa R.] US Army Res Inst Environm Med, Thermal & Mt Med Div, Natick, MA USA. [Klett, Hagen; Timmer, Jens] Univ Freiburg, Inst Phys, D-79106 Freiburg, Germany. [Timmer, Jens] Univ Freiburg, BIOSS Ctr Biol Signalling Studies, D-79106 Freiburg, Germany. RP Rodriguez-Fernandez, M (reprint author), Univ Calif Santa Barbara, Dept Chem Engn, Santa Barbara, CA 93106 USA. EM maria.rodriguez.fernan@gmail.com RI Rodriguez-Fernandez, Maria/I-7193-2016 OI Rodriguez-Fernandez, Maria/0000-0003-1966-2920 FU U.S. Army Research Office [W911NF-09-0001] FX This work was supported in part by the Institute for Collaborative Biotechnologies through Grant W911NF-09-0001 from the U.S. Army Research Office. NR 39 TC 0 Z9 0 U1 0 U2 7 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0025-5564 EI 1879-3134 J9 MATH BIOSCI JI Math. Biosci. PD FEB PY 2015 VL 260 SI SI BP 35 EP 46 DI 10.1016/j.mbs.2014.07.011 PG 12 WC Biology; Mathematical & Computational Biology SC Life Sciences & Biomedicine - Other Topics; Mathematical & Computational Biology GA CB4CF UT WOS:000349575100007 PM 25119202 ER PT J AU Lacey, SD Wan, JY Cresce, AV Russell, SM Dai, JQ Bao, WZ Xu, K Hu, LB AF Lacey, Steven D. Wan, Jiayu Cresce, Arthur von Wald Russell, Selena M. Dai, Jiaqi Bao, Wenzhong Xu, Kang Hu, Liangbing TI Atomic Force Microscopy Studies on Molybdenum Disulfide Flakes as Sodium-Ion Anodes SO NANO LETTERS LA English DT Article DE In situ AFM; MoS2; wrinkling; SEI; sodium-ion battery; microbattery ID SOLID-ELECTROLYTE INTERPHASE; TRANSITION-METAL DICHALCOGENIDES; IN-SITU; LITHIUM INTERCALATION; BATTERY APPLICATIONS; CARBON NANOFIBERS; MOS2 NANOSHEETS; INSERTION; PERFORMANCE; LIQUID AB A microscale battery comprised of mechanically exfoliated molybdenum disulfide (MoS2) flakes with copper connections and a sodium metal reference was created and investigated as an intercalation model using in situ atomic force microscopy in a dry room environment. While an ethylene carbonate-based electrolyte with a low vapor pressure allowed topographical observations in an open cell configuration, the planar microbattery was used to conduct in situ measurements to understand the structural changes and the concomitant solid electrolyte interphase (SEI) formation at the nanoscale. Topographical observations demonstrated permanent wrinkling behavior of MoS2 electrodes upon sodiation at 0.4 V. SEI formation occurred quickly on both flake edges and planes at voltages before sodium intercalation. Force spectroscopy measurements provided quantitative data on the SEI thickness for MoS2 electrodes in sodium-ion batteries for the first time. C1 [Lacey, Steven D.; Wan, Jiayu; Dai, Jiaqi; Bao, Wenzhong; Hu, Liangbing] Univ Maryland, Dept Mat Sci & Engn, College Pk, MD 20742 USA. [Cresce, Arthur von Wald; Russell, Selena M.; Xu, Kang] US Army Res Lab, Electrochem Branch, Power & Energy Div, Sensor & Electron Devices Directorate, Adelphi, MD 20783 USA. RP Hu, LB (reprint author), Univ Maryland, Dept Mat Sci & Engn, College Pk, MD 20742 USA. EM binghu@umd.edu RI Bao, Wenzhong/B-2453-2012; Hu, Liangbing/N-6660-2013 OI Bao, Wenzhong/0000-0002-3871-467X; FU NSF [CBET-1335979/1335944]; Department of Energy Applied Battery Research (DOE-ABR) Program; U.S. Army Research Laboratory FX We acknowledge the support from NSF CBET-1335979/1335944. Partial financial support from Department of Energy Applied Battery Research (DOE-ABR) Program is appreciated. S.R. was supported by an appointment to the U.S. Army Research Laboratory Postdoctoral Fellowship Program administered by the Oak Ridge Associated Universities through a cooperative agreement with the U.S. Army Research Laboratory. NR 38 TC 28 Z9 28 U1 23 U2 217 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1530-6984 EI 1530-6992 J9 NANO LETT JI Nano Lett. PD FEB PY 2015 VL 15 IS 2 BP 1018 EP 1024 DI 10.1021/nl503871s PG 7 WC Chemistry, Multidisciplinary; Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied; Physics, Condensed Matter SC Chemistry; Science & Technology - Other Topics; Materials Science; Physics GA CB4DI UT WOS:000349578000033 PM 25549278 ER PT J AU Lien, DH Kang, JS Amani, M Chen, K Tosun, M Wang, HP Roy, T Eggleston, MS Wu, MC Dubey, M Lee, SC He, JH Javey, A AF Lien, Der-Hsien Kang, Jeong Seuk Amani, Matin Chen, Kevin Tosun, Mahmut Wang, Hsin-Ping Roy, Tania Eggleston, Michael S. Wu, Ming C. Dubey, Madan Lee, Si-Chen He, Jr-Hau Javey, Ali TI Engineering Light Outcoupling in 2D Materials SO NANO LETTERS LA English DT Article DE 2D materials; light outcoupling; substrate interference; photoluminescence; Raman ID RAMAN-SPECTROSCOPY; LAYER MOS2; GRAPHENE; WSE2; PHOTOLUMINESCENCE; EMISSION; DIODES; ENERGY; FILMS AB When light is incident on 2D transition metal dichalcogenides (TMDCs), it engages in multiple reflections within underlying substrates, producing interferences that lead to enhancement or attenuation of the incoming and outgoing strength of light. Here, we report a simple method to engineer the light outcoupling in semiconducting TMDCs by modulating their dielectric surroundings. We show that by modulating the thicknesses of underlying substrates and capping layers, the interference caused by substrate can significantly enhance the light absorption and emission of WSe2, resulting in a similar to 11 times increase in Raman signal and a similar to 30 times increase in the photoluminescence (PL) intensity of WSe2. On the basis of the interference model, we also propose a strategy to control the photonic and optoelectronic properties of thin-layer WSe2. This work demonstrates the utilization of outcoupling engineering in 2D materials and offers a new route toward the realization of novel optoelectronic devices, such as 2D LEDs and solar cells. C1 [Lien, Der-Hsien; Kang, Jeong Seuk; Amani, Matin; Chen, Kevin; Tosun, Mahmut; Wang, Hsin-Ping; Roy, Tania; Eggleston, Michael S.; Wu, Ming C.; Javey, Ali] Univ Calif Berkeley, Berkeley, CA 94720 USA. [Lien, Der-Hsien; Kang, Jeong Seuk; Amani, Matin; Chen, Kevin; Tosun, Mahmut; Wang, Hsin-Ping; Roy, Tania; Javey, Ali] Univ Calif Berkeley, Lawrence Berkeley Natl Lab, Div Mat Sci, Berkeley, CA 94720 USA. [Lien, Der-Hsien; Wang, Hsin-Ping; He, Jr-Hau] KAUST, Comp Elect & Math Sci & Engn CEMSE Div, Thuwal 239556900, Saudi Arabia. [Lien, Der-Hsien; Wang, Hsin-Ping; Lee, Si-Chen] Natl Taiwan Univ, Inst Elect Engn, Dept Elect Engn, Taipei 10617, Taiwan. [Dubey, Madan] US Army Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA. RP He, JH (reprint author), KAUST, Comp Elect & Math Sci & Engn CEMSE Div, Thuwal 239556900, Saudi Arabia. EM jrhau.he@kaust.edu.sa; ajavey@eecs.berkeley.edu RI He, Jr-Hau/B-5141-2011; Javey, Ali/B-4818-2013 OI He, Jr-Hau/0000-0003-1886-9241; NR 27 TC 25 Z9 25 U1 6 U2 85 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1530-6984 EI 1530-6992 J9 NANO LETT JI Nano Lett. PD FEB PY 2015 VL 15 IS 2 BP 1356 EP 1361 DI 10.1021/nl504632u PG 6 WC Chemistry, Multidisciplinary; Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied; Physics, Condensed Matter SC Chemistry; Science & Technology - Other Topics; Materials Science; Physics GA CB4DI UT WOS:000349578000085 PM 25602462 ER PT J AU Karl, JP Thompson, LA Niro, PJ Margolis, LM McClung, JP Cao, JJ Whigham, LD Combs, GF Young, AJ Lieberman, HR Pasiakos, SM AF Karl, J. Philip Thompson, Lauren A. Niro, Philip J. Margolis, Lee M. McClung, James P. Cao, Jay J. Whigham, Leah D. Combs, Gerald F., Jr. Young, Andrew J. Lieberman, Harris R. Pasiakos, Stefan M. TI Transient decrements in mood during energy deficit are independent of dietary protein-to-carbohydrate ratio SO PHYSIOLOGY & BEHAVIOR LA English DT Article DE Macronutrient composition; Neurotransmitter precursor; Weight loss; Cognition; Sleep; Recommended dietary allowance ID SUBJECTIVE SLEEP QUALITY; WEIGHT-LOSS; COGNITIVE PERFORMANCE; OBESE WOMEN; BRAIN; TRIAL; RESTRICTION; MAINTENANCE; OVERWEIGHT; PRECURSOR AB Energy deficit and dietary macronutrient intake are thought to independently modulate cognition, mood and sleep. To what extent manipulating the dietary ratio of protein-to-carbohydrate affects mood, cognition and sleep during short-term energy deficit is undetermined. Using a randomized, block design, 39 non-obese young adults (21 +/- 1 years, BMI 25 +/- 1 kg/m(2)) consumed diets containing 0.8 g, 1.6 g or 2.4 g protein per kg body weight per day for 31 days. Carbohydrate intake was reduced to accommodate higher protein intakes while dietary fat was maintained at 30% of total energy intake. Cognitive performance, mood, self-reported sleep quality, and plasma amino add concentrations were periodically assessed during a 10-day energy balance period and a subsequent 21 -day, 40% energy deficit period. Anger, tension and total mood disturbance increased during the initial ten days of energy deficit (P < 0.05), but by the end of the energy deficit returned to levels not different from those measured during energy balance. No effects of dietary protein-to-carbohydrate ratio on cognitive performance, mood or self-reported sleep quality were observed during energy balance or energy deficit. Thus, high-protein, low-carbohydrate, moderate-fat diets do not appear to benefit or impair cognition, mood or sleep in non-obese adults during energy deficit. These findings suggest that energy deficit may initially be psychologically difficult for non-obese individuals attempting to lose weight, but that these changes are transient. Employing strategies that alleviate decrements in mood during this initial period of adaptation may help sustain weight loss efforts. Published by Elsevier Inc. C1 [Karl, J. Philip; Thompson, Lauren A.; Niro, Philip J.; Margolis, Lee M.; McClung, James P.; Young, Andrew J.; Lieberman, Harris R.; Pasiakos, Stefan M.] US Army, Mil Nutr Div, Environm Med Res Inst, Natick, MA 01760 USA. [Cao, Jay J.; Combs, Gerald F., Jr.] ARS, Grand Forks Human Nutr Res Ctr, USDA, Grand Forks, ND 58203 USA. [Whigham, Leah D.] Paso del Norte Inst Hlth Living, El Paso, TX 79968 USA. RP Pasiakos, SM (reprint author), US Army, Environm Med Res Inst, 15 Kansas St,Bldg 42, Natick, MA 01760 USA. EM james.p.karl@us.army.mil; lauren.a.thompson@us.army.mil; philip.niro@us.army.mil; lee.m.margolis.ctr@mail.mil; james.p.mcclung8.civ@mail.mil; jay.cao@ars.usda.gov; ldwhigham@utep.edu; gerald.combs@ars.usda.gov; andrew.j.young.civ@mail.mil; harris.lieberman@us.army.mil; stefan.pasiakos@us.army.mil RI Pasiakos, Stefan/E-6295-2014; Biguzzi, Felipe/E-4724-2015; OI Pasiakos, Stefan/0000-0002-5378-5820; Karl, J. Philip/0000-0002-5871-2241; , Lee/0000-0002-0652-1304; Whigham, Leah/0000-0002-5376-8967 FU U.S. Army Medical Research and Material Command; U.S. Department of Agriculture, Agricultural Research Service [58-1950-7-707] FX The U.S. Army Medical Research and Material Command and the U.S. Department of Agriculture, Agricultural Research Service, under agreement No. 58-1950-7-707. NR 44 TC 1 Z9 1 U1 4 U2 14 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0031-9384 J9 PHYSIOL BEHAV JI Physiol. Behav. PD FEB PY 2015 VL 139 BP 524 EP 531 DI 10.1016/j.physbeh.2014.11.068 PG 8 WC Psychology, Biological; Behavioral Sciences SC Psychology; Behavioral Sciences GA CB4BY UT WOS:000349574400072 PM 25479571 ER PT J AU Edillo, FE Halasa, YA Largo, FM Erasmo, JNV Amoin, NB Alera, MTP Yoon, IK Alcantara, AC Shepard, DS AF Edillo, Frances E. Halasa, Yara A. Largo, Francisco M. Erasmo, Jonathan Neil V. Amoin, Naomi B. Alera, Maria Theresa P. Yoon, In-Kyu Alcantara, Arturo C. Shepard, Donald S. TI Economic Cost and Burden of Dengue in the Philippines SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID SOUTHEAST-ASIA; DISEASE BURDEN; CHILDREN; AMERICA; ILLNESS; VIRUSES AB Dengue, the world's most important mosquito-borne viral disease, is endemic in the Philippines. During 2008-2012, the country's Department of Health reported an annual average of 117,065 dengue cases, placing the country fourth in dengue burden in southeast Asia. This study estimates the country's annual number of dengue episodes and their economic cost. Our comparison of cases between active and passive surveillance in Punta Princesa, Cebu City yielded an expansion factor of 7.2, close to the predicted value (7.0) based on the country's health system. We estimated an annual average of 842,867 clinically diagnosed dengue cases, with direct medical costs (in 2012 US dollars) of $345 million ($3.26 per capita). This is 54% higher than an earlier estimate without Philippines-specific costs. Ambulatory settings treated 35% of cases (representing 10% of direct costs), whereas inpatient hospitals served 65% of cases (representing 90% of direct costs). The economic burden of dengue in the Philippines is substantial. C1 [Edillo, Frances E.; Amoin, Naomi B.] Univ San Carlos, Dept Biol, Cebu, Philippines. Brandeis Univ, Waltham, MA 02454 USA. [Largo, Francisco M.] Univ San Carlos, Dept Econ, Cebu, Philippines. Dept Hlth Reg 7, Cebu, Philippines. [Alera, Maria Theresa P.] Philippine Armed Forces Res Inst Med Sci, Virol Res Unit, Cebu, Philippines. [Yoon, In-Kyu] Armed Forces Res Inst Med Sci, Dept Virol, Bangkok 10400, Thailand. [Alcantara, Arturo C.] Philippine Hlth Insurance Corp, Manila, Philippines. RP Shepard, DS (reprint author), Brandeis Univ, Schneider Inst Hlth Policy, Heller Sch, MS 035, Waltham, MA 02454 USA. EM feedillo@usc.edu.ph; yara@brandeis.edu; fmlargo@gmail.com; jneilverasmo@yahoo.com; naomiamoin@yahoo.com; mariatheresa.alera@afrims.org; yooni@afrims.org; art.alcantara@gmail.com; shepard@brandeis.edu FU Sanofi Pasteur, Inc.; Armed Forces Health Surveillance Center-Global Emerging Infections Surveillance and Response System FX This work was funded by a research agreement from Sanofi Pasteur, Inc. to Brandeis University. The Punta Princesa cohort study was funded by the Armed Forces Health Surveillance Center-Global Emerging Infections Surveillance and Response System. NR 39 TC 10 Z9 10 U1 0 U2 2 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 EI 1476-1645 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD FEB PY 2015 VL 92 IS 2 BP 360 EP 366 DI 10.4269/ajtmh.14-0139 PG 7 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA CA6ZC UT WOS:000349065400032 PM 25510723 ER PT J AU Filone, CM Dower, K Cowley, GS Hensley, LE Connor, JH AF Filone, Claire Marie Dower, Ken Cowley, Glenn S. Hensley, Lisa E. Connor, John H. TI Probing the Virus Host Interaction in High Containment: An Approach Using Pooled Short Hairpin RNA SO ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES LA English DT Article ID NIEMANN-PICK C1; HIGH-THROUGHPUT; VACCINIA VIRUS; EBOLA VIRUSES; CORE PROTEIN; IN-VITRO; CELLS; IDENTIFICATION; SCREEN; GENE AB The study of viruses in high containment offers unique challenges for technology-intense approaches. These approaches include high-throughput screening for small-molecule antivirals and genetic perturbation-based screens for host factors required for viral replication. Here, we describe the use of whole-genome scale pooled short hairpin RNA (shRNA) libraries to screen for host factors necessary for viral infection at BSL2, and the transition of this technique into the BSL4 environment. Pooled screening provides a unique way to circumvent many of the technological challenges associated with other high-throughput screening approaches in high containment. Our pooled screening approach identified host factors involved in the replication of orthopoxviruses (Vaccinia and Monkeypox) and filoviruses (Ebola and Marburg) under conditions that enable straightforward screen-to-follow-up approaches. C1 [Filone, Claire Marie; Dower, Ken; Connor, John H.] Boston Univ, Sch Med, Natl Emerging Infect Dis Lab, Boston, MA 02118 USA. [Cowley, Glenn S.] Broad Inst, Cambridge, MA USA. [Hensley, Lisa E.] US Army Med Res Inst Infect Dis, Ft Detrick, MD USA. RP Connor, JH (reprint author), Boston Univ, Sch Med, Natl Emerging Infect Dis Lab, 620 Albany St, Boston, MA 02118 USA. EM jhconnor@bu.edu OI Connor, John/0000-0002-8867-7256 FU Postgraduate Research Participation Program; U.S. Army Research and Medical Command [5T32AI089673-04]; SPARC grant from the Broad Institute; [R03 MH094169] FX The authors would like to thank the Boston University Flow Cytometry Core Facility, especially Anna Belkina, for assistance with the cell sorting experiment analysis. They would also like to acknowledge the cell sorting staff at the MIT Koch Institute for sorting the VACV screen. They would like to thank Monica Ogg and Kenny Lin for training and assistance in high containment. C.M.F. was supported by the Postgraduate Research Participation Program and the U.S. Army Research and Medical Command administered by the Oak Ridge Institute for Science and Education (ORISE) and training grant 5T32AI089673-04. This work was also supported by a SPARC grant from the Broad Institute and in part by R03 MH094169 to J.H.C. NR 42 TC 0 Z9 0 U1 0 U2 1 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1540-658X EI 1557-8127 J9 ASSAY DRUG DEV TECHN JI ASSAY DRUG DEV. TECHNOL. PD FEB 1 PY 2015 VL 13 IS 1 BP 34 EP 43 DI 10.1089/adt.2014.613 PG 10 WC Biochemical Research Methods; Pharmacology & Pharmacy SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy GA CB7RL UT WOS:000349824900005 PM 25646658 ER PT J AU Azimi, N Xue, Z Hua, LB Takoudis, C Zhang, SS Zhang, ZC AF Azimi, Nasim Xue, Zheng Hua, Libo Takoudis, Christos Zhang, Shengshui Zhang, Zhengcheng TI Additive Effect on the Electrochemical Performance of Lithium-Sulfur Battery SO ELECTROCHIMICA ACTA LA English DT Article DE Electrolyte; LiDFOB additive; Silicon-based electrolyte; Coulombic efficiency; Lithium-sulfur batteries ID LI-S BATTERIES; DISCHARGE PERFORMANCE; LIQUID ELECTROLYTE; GRAPHENE OXIDE; COMPOSITE; CELL; CATHODE; CHARGE AB Lithium difluoro(oxalato) borate (LiDFOB) was investigated as an electrolyte additive for the Li-S battery. This additive was identified to be an efficient electrolyte additive to suppress the polysulfide shuttling effect existing in the conventional Li-S chemistry. To detect the positive impact of the new additive, oligo (ethylene glycol) functionalized silane was employed as the electrolyte solvent due to its high solvation capability with the lithium polysulfides. The electrochemical results and the SEM data of Li-S battery using the new electrolyte confirmed the role of the LiDFOB as a critical component to eliminate the shuttling of the dissolved polysulfides thus enabling a high coulombic efficiency. (C) 2014 Elsevier Ltd. All rights reserved. C1 [Azimi, Nasim; Xue, Zheng; Hua, Libo; Zhang, Zhengcheng] Argonne Natl Lab, Chem Sci & Engn Div, Argonne, IL 60439 USA. [Azimi, Nasim; Takoudis, Christos] Univ Illinois, Dept Chem Engn, Chicago, IL 60607 USA. [Azimi, Nasim; Takoudis, Christos] Univ Illinois, Dept Bioengn, Chicago, IL 60607 USA. [Zhang, Shengshui] US Army Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA. RP Zhang, ZC (reprint author), Argonne Natl Lab, Chem Sci & Engn Div, 9700 S Cass Ave, Argonne, IL 60439 USA. EM zzhang@anl.gov RI Zhang, Sheng/A-4456-2012 OI Zhang, Sheng/0000-0003-4435-4110 FU Vehicle Technologies Office, U.S. Department of Energy; UChicago Argonne, LLC [DE-AC02-06CH11357] FX This research is supported by the Vehicle Technologies Office, U.S. Department of Energy. Argonne, a U.S. Department of Energy laboratory, is operated by UChicago Argonne, LLC under contract DE-AC02-06CH11357. Z.Z. would like to thank Prof. Donghai Wang from Pennsylvania State University for the technical discussions. NR 35 TC 8 Z9 8 U1 14 U2 97 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0013-4686 EI 1873-3859 J9 ELECTROCHIM ACTA JI Electrochim. Acta PD FEB 1 PY 2015 VL 154 BP 205 EP 210 DI 10.1016/j.electacta.2014.12.041 PG 6 WC Electrochemistry SC Electrochemistry GA CB3RR UT WOS:000349546500027 ER PT J AU Frankenstein, S Stevens, M Scott, C AF Frankenstein, Susan Stevens, Maria Scott, Constance TI Ingestion of Simulated SMAP L3 Soil Moisture Data into Military Maneuver Planning SO JOURNAL OF HYDROMETEOROLOGY LA English DT Article ID CONE INDEX; LAND; ASSIMILATION AB This paper uses simulated SMAP level-3 (L3) soil moisture data to calculate soil strength directly and compares the results against the current Noah Land Information System-based climatology approach. Based on the availability of data, three sites were chosen for the study: Cheorwon, South Korea; Laboue, Lebanon; and Asham, Nigeria. The simulated SMAP satellite data are representative of May conditions. For all three regions, this is best represented by the "average" soil moisture used in the current climatology approach. The cumulative distribution frequency of the two soil moisture sources indicates good agreement at Asham, Nigeria; mixed agreement at Cheorwon, South Korea; and no agreement at Laboue, Lebanon. Soil strengths and resulting vehicle speeds for a High Mobility Multipurpose Wheeled Vehicle (HMMWV) M1097 were calculated based on the Harmonized World Soil Database soil types used by the two soil moisture sources, as well as with a finer-resolution National Geospatial-Intelligence Agency product. Better agreement was found in soil strengths using the finer-resolution soil product. Finally, fairly large differences in soil moisture become muted in the speed calculations even when all factors except soil strength, slope, and vehicle performance are neglected. It is expected that the 0.04 volumetric uncertainty in the final SMAP L3 soil moisture product will have the greatest effect at low vehicle speeds. Field measurements of soil moisture and strength as well as soil type are needed to verify the results. C1 [Frankenstein, Susan; Scott, Constance] US Army Corps Engineers, Engn Res & Dev Ctr, Cold Regions Res & Engn Lab, Hanover, NH USA. [Stevens, Maria] US Army Corps Engineers, Engn Res & Dev Ctr, Geotechn & Struct Lab, Vicksburg, MS USA. RP Frankenstein, S (reprint author), Erdc, CRREL, 72 Lyme Rd, Hanover, NH 03755 USA. EM susan.frankenstein@usace.army.mil FU Army 6.2 applied research program GeoEnabled Multi-Modal Situation Awareness-Targets and Terrain Simulation (GEMS-T2S) FX This study was funded by the Army 6.2 applied research program GeoEnabled Multi-Modal Situation Awareness-Targets and Terrain Simulation (GEMS-T2S). Recognition also goes to the SMAP Early Adopter Program. NR 37 TC 1 Z9 1 U1 1 U2 9 PU AMER METEOROLOGICAL SOC PI BOSTON PA 45 BEACON ST, BOSTON, MA 02108-3693 USA SN 1525-755X EI 1525-7541 J9 J HYDROMETEOROL JI J. Hydrometeorol. PD FEB PY 2015 VL 16 IS 1 BP 427 EP 440 DI 10.1175/JHM-D-14-0032.1 PG 14 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA CB1DR UT WOS:000349367500028 ER PT J AU Taheri, S Sandu, C Taheri, S Pinto, E Gorsich, D AF Taheri, Sh. Sandu, C. Taheri, S. Pinto, E. Gorsich, D. TI A technical survey on Terramechanics models for tire-terrain interaction used in modeling and simulation of wheeled vehicles SO JOURNAL OF TERRAMECHANICS LA English DT Review DE Wheeled vehicle; Terramechanics; Off-road; Deformable terrain; Tire model; Soil; Parameterization; Mobility ID DISTINCT ELEMENT METHOD; TYRE-SOIL INTERACTION; SOFT SOIL; CONTACT; DYNAMICS; MOBILITY; PERFORMANCES; COMPACTION; RESISTANCE AB Accurate and efficient tire models for deformable terrain operations are essential for performing vehicle simulations. A direct application of an on-road tire model to simulate tire behavior on a deformable terrain such as soft soil is not possible. The methods for modeling and evaluation of performance of the wheeled vehicles on deformable terrains are influenced by different terrain properties in addition to design and operational parameters. These methods are ranged from very simple empirical methods to highly complex finite element methods. This survey covers the most used models that have been developed for wheeled vehicles in off-road applications. The emphasize is on the models that have made a significant contribution in advancement of techniques for characterizing soil, tire, soil tire interaction, experimental analysis, model parameterization and model validation. A description is given for selected studies to familiarize the reader with the general terminologies, formulations and modeling approaches. More importantly, two summary tables are given for three groups of models in which the overall features of each model are reviewed and compared to other models. These tables can be used to understand the general picture of the available techniques, and facilitate selecting the appropriate model for future applications. (C) 2014 ISTVS. Published by Elsevier Ltd. All rights reserved. C1 [Taheri, Sh.; Sandu, C.; Taheri, S.; Pinto, E.] Virginia Tech, Dept Mech Engn, Blacksburg, VA 24061 USA. [Gorsich, D.] US Army, TARDEC, Warren, MI USA. RP Taheri, S (reprint author), Virginia Tech, Dept Mech Engn, Blacksburg, VA 24061 USA. EM taheri@vt.edu FU Automotive Research Center (ARC), a U.S. Army Center of Excellence FX This work has been partially funded by the Automotive Research Center (ARC), a U.S. Army Center of Excellence for Modeling and Simulation of Ground Vehicles. NR 113 TC 10 Z9 13 U1 7 U2 27 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0022-4898 EI 1879-1204 J9 J TERRAMECHANICS JI J. Terramech. PD FEB PY 2015 VL 57 BP 1 EP 22 DI 10.1016/j.jterra.2014.08.003 PG 22 WC Engineering, Environmental SC Engineering GA CB1ZK UT WOS:000349426300001 ER PT J AU Braun, L Sawyer, T Smith, K Hsu, A Behrens, M Chan, D Hutchinson, J Lu, D Singh, R Reyes, J Lopreiato, J AF Braun, LoRanee Sawyer, Taylor Smith, Kathleen Hsu, Angela Behrens, Melinda Chan, Debora Hutchinson, Jeffrey Lu, Downing Singh, Raman Reyes, Joel Lopreiato, Joseph TI Retention of Pediatric Resuscitation Performance After a Simulation-Based Mastery Learning Session: A Multicenter Randomized Trial SO PEDIATRIC CRITICAL CARE MEDICINE LA English DT Article DE degradation; master learning; resuscitation; retention; simulation ID ADVANCED LIFE-SUPPORT; INTENSIVE-CARE-UNIT; DELIBERATE PRACTICE; PATIENT OUTCOMES; RESIDENTS; SKILLS; EDUCATION AB Objectives: Using simulation-based mastery learning, residents can be trained to achieve a predefined performance standard in resuscitation. After mastery is achieved, performance degradation occurs over time. Prior investigations have shown performance retention of 12-14 months following intensive simulation-based mastery learning sessions. We sought to investigate the duration of mastery-level resuscitation performance retention after a single 1- to 2-hour simulation-based mastery learning session. Design: Randomized, prospective trial. Setting: Medical simulation laboratory. Subjects: Convenience sample of 42 pediatric residents. Interventions: Baseline resuscitation performance was determined on four standardized simulation scenarios. After determination of baseline performance, each resident repeated each scenario, as needed, until mastery-level performance was achieved. Residents were then randomized and retested 2, 4, or 6 months later. Statistical analysis on scores at baseline and retesting were used to determine performances changes from baseline and performance retention over time. Measurements and Main Results: Forty-two residents participated in the study (12 in 2 mo group, 14 in 4 mo group, and 16 in 6 mo group). At baseline, postgraduate year-3 residents performed better than postgraduate year-1 residents (p = 0.003). Overall performance on each of the four scenarios improved at retesting. The percent of residents maintaining mastery-level performance showed a significant linear decline (p = 0.039), with a drop at each retesting interval; 92% retained mastery at 2 months, 71% at 4 months, and 56% at 6 months. There was no difference in retention between postgraduate year-1, postgraduate year-2, and postgraduate year-3 residents (p = 0.14). Conclusions: Residents displayed significant improvements in resuscitation performance after a single simulation-based mastery learning session, but performance declined over time, with less than 60% retaining mastery-level performance at 6 months. Our results suggest that relatively frequent refresher training is needed after a single simulation-based mastery learning session. Additional research is needed to determine the duration of performance retention following any specific simulation-based mastery learning intervention. C1 [Braun, LoRanee; Smith, Kathleen; Behrens, Melinda] Madigan Army Med Ctr, Tacoma, WA 98431 USA. [Sawyer, Taylor; Hsu, Angela; Chan, Debora] Tripler Army Med Ctr, Honolulu, HI 96859 USA. [Hutchinson, Jeffrey; Lu, Downing; Lopreiato, Joseph] Walter Reed Natl Mil Med Ctr, Bethesda, MD USA. [Singh, Raman; Reyes, Joel] San Antonio Uniformed Serv Hlth Educ Consortium, San Antonio, TX USA. RP Braun, L (reprint author), Madigan Army Med Ctr, Tacoma, WA 98431 USA. EM loranee.e.braun.mil@mail.mil NR 21 TC 3 Z9 3 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1529-7535 EI 1947-3893 J9 PEDIATR CRIT CARE ME JI Pediatr. Crit. Care Med. PD FEB PY 2015 VL 16 IS 2 BP 131 EP 138 DI 10.1097/PCC.0000000000000315 PG 8 WC Critical Care Medicine; Pediatrics SC General & Internal Medicine; Pediatrics GA CB1KZ UT WOS:000349387600011 PM 25647122 ER PT J AU Soonwera, M Phasornkusolsill, S AF Soonwera, Mayura Phasornkusolsill, Siriporn TI Efficacy of Thai herbal essential oils as green repellent against mosquito vectors SO ACTA TROPICA LA English DT Article DE Repellency; Cananga odorata oil; Cymbopogon citratus oil; Aedes aegypti; Culex quinquefasciatus ID AEDES AB Repellency activity of Thai essential oils derived from ylang ylang (Cananga odorata (Lamk.) Hook.f. & Thomson: Annonaceae) and lemongrass (Cymbopogon citratus (DC.) Stapf: Poaceae) were tested against two mosquito vectors, Aedes aegypti (L.) and Culex quinquefasciatus (Say). There were compared with two chemical repellents (DEET 20% w/w; Sketolene Shield(R) and IR3535, ethyl butylacetylaminopropionate 12.5% w/w; Johnson's Baby Clear Lotion Anti-Mosquito(R)). Each herbal repellent was applied in three diluents; coconut oil, soybean oil and olive oil at 0.33 mu l/cm(2) on the forearm of volunteers. All herbal repellent exhibited higher repellent activity than IR3535 12.5% w/w, but lower repellent activity than DEET 20% w/w. The Cananga odorata oil in coconut oil exhibited excellent activity with 98.9% protection from bites of A. aegypti for 88.7 +/- 10.4 min. In addition, Cymbopogon citratus in olive oil showed excellent activity with 98.8% protection from bites of Culex quinquefasciatus for 170.0 +/- 9.0 min. While, DEET 20% w/w gave protection for 155.0 +/- 7.1-182.0 +/- 12.2 min and 98.5% protection from bites of two mosquito species. However, all herbal repellent provided lower repellency activity (97.4-98.9% protection for 10.5-88.7 min) against Aedes aegypti than Culex quinquefasciatus (98.3-99.2% protection for 60-170 min). Our data exhibited that Cananga odorata oil and Cymbopogon citratus oil are suitable to be used as green repellents for mosquito control, which are safe for humans, domestic animals and environmental friendly. (C) 2014 Elsevier B.V. All rights reserved. C1 [Soonwera, Mayura] King Mongkuts Inst Technol Ladkrabang, Fac Agr Technol, Plant Prod Technol Sect, Bangkok 10520, Thailand. [Phasornkusolsill, Siriporn] US Army, Med Component, Armed Forces Res Inst Med Sci, Dept Entomol, Bangkok 10400, Thailand. RP Phasornkusolsill, S (reprint author), US Army, Med Component, Armed Forces Res Inst Med Sci, Dept Entomol, Bangkok 10400, Thailand. EM msiriporn@hotmail.com FU Faculty of Agricultural Technology, King Mongkut's Institute of Technology Ladkrabang (KMITL), Bangkok, Thailand FX The authors are highly grateful to Faculty of Agricultural Technology, King Mongkut's Institute of Technology Ladkrabang (KMITL), Bangkok, Thailand for providing financial assistance to carry out this study. Grateful thanks are due to the volunteers from Plant Production Technology Section, Faculty of Agricultural Technology, KMITL for their assistance in repellent tests. Thanks are extended to plant taxonomist of Faculty of Agricultural Technology, KMITL for herbal identification. The standard disclaimer that the findings/conclusions reflect the efforts and opinions of the authors and not of the US Army or AFRIMS or the Department of Entomology. NR 20 TC 3 Z9 3 U1 6 U2 24 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0001-706X EI 1873-6254 J9 ACTA TROP JI Acta Trop. PD FEB PY 2015 VL 142 BP 127 EP 130 DI 10.1016/j.actatropica.2014.11.010 PG 4 WC Parasitology; Tropical Medicine SC Parasitology; Tropical Medicine GA CA8UU UT WOS:000349197200019 PM 25438256 ER PT J AU Reiter, MJ Schwope, RB Bui-Mansfield, LT Lisanti, CJ Glasgow, SC AF Reiter, Michael J. Schwope, Ryan B. Bui-Mansfield, Liem T. Lisanti, Christopher J. Glasgow, Sean C. TI Surgical Management of Retrorectal Lesions: What the Radiologist Needs to Know SO AMERICAN JOURNAL OF ROENTGENOLOGY LA English DT Review DE CT; MRI; presacral; retrorectal ID EXTRAMEDULLARY HEMATOPOIESIS; RETROPERITONEAL FIBROSIS; PRESACRAL TUMORS; IMAGING FINDINGS; TAILGUT CYSTS; ADULTS; SPACE; CT; BIOPSY; MASSES AB OBJECTIVE. The purpose of this article is to highlight the most salient imaging features of retrorectal masses with regard to surgical planning, preoperative biopsy, and identification of nonneoplastic mimickers of malignancy. CONCLUSION. Retrorectal tumors are associated with high morbidity. CT and MRI aid in preoperative planning because surgical resection is the treatment of choice for both benign and malignant entities. Radiologists need to understand the operative techniques currently used for retrorectal tumors because the first attempt at excision is the best chance for complete resection and optimal outcome. C1 [Reiter, Michael J.; Schwope, Ryan B.; Bui-Mansfield, Liem T.; Lisanti, Christopher J.] Brooke Army Med Ctr, Dept Radiol, San Antonio, TX 78234 USA. [Glasgow, Sean C.] Brooke Army Med Ctr, Dept Surg, San Antonio, TX USA. RP Reiter, MJ (reprint author), Brooke Army Med Ctr, Dept Radiol, 3551 Roger Brooke Dr, San Antonio, TX 78234 USA. EM mikereiter13@yahoo.com NR 36 TC 2 Z9 2 U1 0 U2 0 PU AMER ROENTGEN RAY SOC PI RESTON PA 1891 PRESTON WHITE DR, SUBSCRIPTION FULFILLMENT, RESTON, VA 22091 USA SN 0361-803X EI 1546-3141 J9 AM J ROENTGENOL JI Am. J. Roentgenol. PD FEB PY 2015 VL 204 IS 2 BP 386 EP 395 DI 10.2214/AJR.14.12791 PG 10 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA CA1DD UT WOS:000348652300044 PM 25615762 ER PT J AU Bui-Mansfield, LT Chen, DC O'Brien, SD AF Bui-Mansfield, Liem T. Chen, Dillon C. O'Brien, Seth D. TI Accuracy of Ultrasound of Musculoskeletal Soft-Tissue Tumors SO AMERICAN JOURNAL OF ROENTGENOLOGY LA English DT Letter ID MASSES C1 [Bui-Mansfield, Liem T.; Chen, Dillon C.; O'Brien, Seth D.] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. RP Bui-Mansfield, LT (reprint author), Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. NR 4 TC 2 Z9 2 U1 0 U2 0 PU AMER ROENTGEN RAY SOC PI RESTON PA 1891 PRESTON WHITE DR, SUBSCRIPTION FULFILLMENT, RESTON, VA 22091 USA SN 0361-803X EI 1546-3141 J9 AM J ROENTGENOL JI Am. J. Roentgenol. PD FEB PY 2015 VL 204 IS 2 BP W218 EP W218 DI 10.2214/AJR.14.13335 PG 1 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA CA1DD UT WOS:000348652300017 PM 25615787 ER PT J AU Williams, KS Labukas, JP Rodriguez-Santiago, V Andzelm, JW AF Williams, Kristen S. Labukas, Joseph P. Rodriguez-Santiago, Victor Andzelm, Jan W. TI First Principles Modeling of Water Dissociation on Mg(0001) and Development of a Mg Surface Pourbaix Diagram SO CORROSION LA English DT Article DE magnesium; modeling; potential-pH diagram; thermodynamics; water ID DENSITY-FUNCTIONAL THEORY; EARTH METAL-IONS; DOPED MG(0001); HYDROGENATION MECHANISM; 1ST-PRINCIPLES CALCULATIONS; ELECTRONIC-STRUCTURE; OXYGEN REDUCTION; AB-INITIO; MAGNESIUM; MOLECULES AB Density functional theory (DFT) was used to study water dissociation on the Mg(0001) surface. The metal/water interface was modeled with a supercell approach, consisting of an extended metal surface coupled to an implicit solvent medium. Several electrochemical reactions were studied on the Mg surface, and it was found that dissociation of adsorbed water is thermodynamically favorable, and that the Mg(0001) surface has multiple 'active sites' that can accommodate adsorbed hydroxyl groups (*OH). This is similar to previous first principles findings of oxygen adsorption on Mg(0001). It was also found that the local structure of an adsorbed hydroxyl monolayer mimics that of the crystal structure of brucite, Mg(OH)(2). Lastly, DFT-calculated reaction enthalpies were used to reproduce the bulk Mg Pourbaix diagram, and Pourbaix's formalism was extended to develop a theoretical Mg surface Pourbaix diagram. From this, it was shown that the enthalpy of hydroxylation of Mg(0001) becomes more negative with increasing surface coverage of *OH groups. This indicates that the presence of adsorbed *OH species provides an energetic driving force for water dissociation on Mg(0001). Furthermore, the corrosive region of the Mg Pourbaix diagram can be suppressed if *OH adsorption is limited to certain low-energy active sites, where they form a stable hydroxide surface. C1 [Williams, Kristen S.; Labukas, Joseph P.; Rodriguez-Santiago, Victor; Andzelm, Jan W.] US Army Res Lab, Mat & Mfg Sci Div, Aberdeen Proving Ground, MD 21005 USA. RP Williams, KS (reprint author), US Army Res Lab, RDRL WMM G 4600 Deer Creek Loop, Aberdeen Proving Ground, MD 21005 USA. EM kristen.s.williams7.ctr@mail.mil FU U.S. Department of Energy; USARL FX K.W. and V.R.S. are supported in part by an appointment to the Postgraduate Research Participation Program at the U.S. Army Research Laboratory, administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the U.S. Department of Energy and USARL. This work was also supported in part by a grant of computer time from the DoD High Performance Computing Modernization Program at the U.S. Air Force Research Laboratory DoD Supercomputing Resource Center. NR 81 TC 5 Z9 5 U1 15 U2 47 PU NATL ASSOC CORROSION ENG PI HOUSTON PA 1440 SOUTH CREEK DRIVE, HOUSTON, TX 77084-4906 USA SN 0010-9312 EI 1938-159X J9 CORROSION JI Corrosion PD FEB PY 2015 VL 71 IS 2 BP 209 EP 223 DI 10.5006/1322 PG 15 WC Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Materials Science; Metallurgy & Metallurgical Engineering GA CA6IP UT WOS:000349015600009 ER PT J AU Kennedy, AJ Laird, JG Lounds, C Gong, P Barker, ND Brasfield, SM Russell, AL Johnson, MS AF Kennedy, Alan J. Laird, Jennifer G. Lounds, Chris Gong, Ping Barker, Natalie D. Brasfield, Sandra M. Russell, Amber L. Johnson, Mark S. TI INTER- AND INTRASPECIES CHEMICAL SENSITIVITY: A CASE STUDY USING 2,4-DINITROANISOLE SO ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY LA English DT Article DE Dinitroanisole; Dinitrophenol; Toxicity; Insensitive munition; Species sensitivity ID INSENSITIVE MUNITIONS COMPOUND; SPECIES SENSITIVITY; DAPHNIA-MAGNA; DNAN; CONSTITUENTS; TOXICITY; MS AB Insensitive munitions offer increased safety because of their insensitivity to unintended detonation relative to historically used formulations such as 2,4,6-trinitrotoluene (TNT). Dinitroanisole (DNAN) is an insensitive munition constituent, and its solubility and stability warrant investigations of potential toxicological hazard related to manufacturing discharges and training ranges. Although ecotoxicology data are available for other insensitive munition constituents, few data are available for DNAN. In the present study, acute and chronic exposures of a fish (Pimephales promelas) and 2 cladocerans (Ceriodaphnia dubia, Daphnia pulex) were conducted. The 50% lethal concentration (LC50) values of DNAN ranged from 14.2mg/L to 42.0mg/L, depending on species. In chronic exposures, fish survival (LC50=10.0mg/L) was more sensitive than cladoceran survival (LC50=13.7 to >24.2mg/L). However, cladoceran reproduction was equally or more sensitive to DNAN (50% inhibition values 2.7-10.6mg/L, depending on species) than fish endpoints. Daphnia pulex was the most sensitive species, with only slight differences between the 3 populations tested. Although the aquatic toxicity of DNAN was lower than previously reported in the literature for TNT, future research is needed to determine the potential synergistic toxicity of all the constituents in insensitive munition mixtures and the implications of photo-oxidation. Environ Toxicol Chem 2014;9999:1-10. (c) 2014 SETAC C1 [Kennedy, Alan J.; Laird, Jennifer G.; Brasfield, Sandra M.] US Army Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA. [Lounds, Chris; Gong, Ping; Barker, Natalie D.; Russell, Amber L.] Badger Tech Serv, San Antonio, TX USA. [Johnson, Mark S.] US Army Inst Publ Hlth, Aberdeen Proving Ground, MD USA. RP Kennedy, AJ (reprint author), US Army Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA. EM Alan.J.Kennedy@usace.army.mil FU Army Environmental Quality Technology Basic Research Program (US Army Engineer Research and Development Center); Strategic Environmental Research and Development Program [ER 2223] FX This work was funded by the Army Environmental Quality Technology Basic Research Program (US Army Engineer Research and Development Center, E. Ferguson, Technical Director) and the Strategic Environmental Research and Development Program (Project ER 2223). We appreciate J. Smith and J. Chappell (US Army Engineer Research and Development Center) for HPLC analysis and D. Morrow (US Army Institute of Public Health) for gas chromatography analysis. We thank H. Webb and A. Beckerman for donating D. pulex for our internal cultures. We appreciate constructive comments from 2 internal (J. Stanley, J. Johnson) and 4 anonymous reviewers. Permission was granted by the chief of engineers to publish this information. NR 40 TC 3 Z9 3 U1 3 U2 25 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0730-7268 EI 1552-8618 J9 ENVIRON TOXICOL CHEM JI Environ. Toxicol. Chem. PD FEB PY 2015 VL 34 IS 2 BP 402 EP 411 DI 10.1002/etc.2819 PG 10 WC Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA CA6BU UT WOS:000348994200023 PM 25476794 ER PT J AU Ledford, CJW Canzona, MR Seehusen, DA Cafferty, LA Schmidt, ME Huang, JC Villagran, MM AF Ledford, Christy J. W. Canzona, Mollie R. Seehusen, Dean A. Cafferty, Lauren A. Schmidt, Monica E. Huang, Joseph C. Villagran, Melinda M. TI Differences in Physician Communication When Patients Ask Versus Tell About Religion/Spirituality: A Pilot Study SO FAMILY MEDICINE LA English DT Article ID MEDICAL ENCOUNTERS; SPIRITUALITY; PARTICIPATION; RELIGION; CONSULTATIONS; CARE; BELIEFS AB BACKGROUND AND OBJECTIVES: Research suggests that physicians should pursue spiritual issues and that patients desire to discuss religion/spirituality (R/S) in medical encounters. This study explored the differences in physician communication in response to patient inquiry or disclosure of R/S and hypothesizes that physician communication will differ when patients disclose R/S as contrasted to inquire about R/S. METHODS: Family physicians and family medicine resident physicians were recruited from a family medicine department at a community hospital (n=27). An objective structured clinical examination, with a standardized patient encounter, was used to expose the participants to a conversation regarding R/S. Participants were assigned, by alternating clustered assignment, to two conditions: patient disclosure of R/S or patient inquiry about physician R/S. The primary outcome measure was physician response, specifically physician-control, partnership-building, and supportive-talk messages. RESULTS: When the patient asks questions about R/S, physicians communicate more control messages and less supportive talk messages than when the patient discloses information about R/S. CONCLUSIONS: Training physicians to anticipate and respond to patient disclosure and inquiry will increase the likelihood they can enact patient-centered strategies. These methods should focus on teaching residents how to be sensitive to the R/S context of their patients and to recognize their own intuitive reactions to patient communication in that context. C1 [Ledford, Christy J. W.] Univ Hlth Sci, Dept Family Med, Uniformed Serv, Bethesda, MD 20815 USA. [Canzona, Mollie R.] George Mason Univ, Fairfax, VA 22030 USA. [Seehusen, Dean A.] Eisenhower Army Med Ctr, Dept Family & Community Med, Ft Gordon, GA USA. [Schmidt, Monica E.; Huang, Joseph C.] Ft Belvoir Community Hosp, Dept Family Med, Ft Belvoir, VA USA. [Cafferty, Lauren A.; Villagran, Melinda M.] Texas State Univ San Marcos, San Marcos, TX USA. RP Ledford, CJW (reprint author), Univ Hlth Sci, Dept Family Med, Uniformed Serv, Bethesda, MD 20815 USA. EM christian.ledford@usuhs.edu FU Fort Belvoir Community Hospital Department of Clinical Investigations FX Ethical approval was granted by Fort Belvoir Community Hospital Department of Clinical Investigations. NR 34 TC 2 Z9 3 U1 1 U2 4 PU SOC TEACHERS FAMILY MEDICINE PI LEAWOOD PA 11400 TOMAHAWK CREEK PARKWAY, STE 540, LEAWOOD, KS 66207 USA SN 0742-3225 EI 1938-3800 J9 FAM MED JI Fam. Med. PD FEB PY 2015 VL 47 IS 2 BP 138 EP 142 PG 5 WC Primary Health Care; Medicine, General & Internal SC General & Internal Medicine GA CA9WS UT WOS:000349276100009 PM 25646987 ER PT J AU Cole, DM AF Cole, David M. TI Laboratory observations of frictional sliding of individual contacts in geologic materials SO GRANULAR MATTER LA English DT Article DE Contact mechanics; Friction; Experiments; Granular media; Coefficient of friction ID INITIAL FRICTION; ROUGH SURFACES; ROCK FRICTION; MECHANICS; MICROMECHANICS; COEFFICIENT AB This paper gives the results of grain-to-grain sliding friction experiments on several naturally occurring geologic materials and two manufactured materials. The materials include quartz sands with mean grain size ranging from 0.14 to 3 mm, crushed and ball milled gneiss with mm, magnesite (limestone) with mm, and Caicos ooids with mm. The reference materials include manufactured glass beads ( and 1.0 mm) and spheres of a synthetic material (Delrin, and 5.08 mm). The experiments involved normal loads that ranged from 0.46 to 20 N, depending on material, and the subsequent application of an increasing shear force at a loading rate of 1 . This work contributes to the goal of providing high-fidelity contact models for use in discrete element simulations of naturally occurring granular materials. The results presented here provide a picture of shear force-displacement behavior up to and through the onset of macroscopic sliding. For natural materials with relatively rough surfaces, the coefficient of friction ranged from 0.1 to 0.9 at normal force levels N, but tended to converge to a narrower range (0.24-0.62) at higher levels. Grains with low surface roughness (glass beads, synthetic material and the 3-mm-diameter sand), on the other hand, exhibited a trend of decreasing with increasing , with terminal values in the range of 0.1-0.2 for N. This behavior is explained in terms of the relationship between the normal force and the true area of contact. Additionally, observations of free sliding observed under cyclic shear loading are reported. C1 Engn Res & Dev Ctr, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. RP Cole, DM (reprint author), Engn Res & Dev Ctr, Cold Reg Res & Engn Lab, 72 Lyme Rd, Hanover, NH 03755 USA. EM David.M.Cole@usace.army.mil FU ERDC's Military Engineering Basic Research Program FX The author gratefully acknowledges the financial support of ERDC's Military Engineering Basic Research Program. This work was made possible by the excellent technical support of Douglas Punt, William Burch and John Gagnon of ERDC-CRREL. Helpful comments on the manuscript from Dr. Mark Hopkins of ERDC-CRREL are gratefully acknowledged. NR 32 TC 2 Z9 2 U1 0 U2 11 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1434-5021 EI 1434-7636 J9 GRANUL MATTER JI Granul. Matter PD FEB PY 2015 VL 17 IS 1 BP 95 EP 110 DI 10.1007/s10035-014-0526-0 PG 16 WC Materials Science, Multidisciplinary; Mechanics; Physics, Applied SC Materials Science; Mechanics; Physics GA CA6ND UT WOS:000349030100008 ER PT J AU Crawford, KW Wakabi, S Magala, F Kibuuka, H Liu, M Hamm, TE AF Crawford, K. W. Wakabi, S. Magala, F. Kibuuka, H. Liu, M. Hamm, T. E. TI Evaluation of treatment outcomes for patients on first-line regimens in US President's Emergency Plan for AIDS Relief (PEPFAR) clinics in Uganda: predictors of virological and immunological response from RV288 analyses SO HIV MEDICINE LA English DT Article DE first-line regimen; sub-Saharan Africa; treatment outcomes; Uganda; US President's Emergency Plan for AIDS Relief (PEPFAR); virological suppression ID HUMAN-IMMUNODEFICIENCY-VIRUS; T-CELL RECOVERY; ACTIVE ANTIRETROVIRAL THERAPY; HIV-INFECTED PATIENTS; TOTAL LYMPHOCYTE COUNT; REFERENCE RANGES; IMMUNE ACTIVATION; DRUG-RESISTANCE; VIRAL LOAD; ADULTS AB ObjectivesViral load (VL) monitoring is recommended, but seldom performed, in resource-constrained countries. RV288 is a US President's Emergency Plan for AIDS Relief (PEPFAR) basic programme evaluation to determine the proportion of patients on treatment who are virologically suppressed and to identify predictors of virological suppression and recovery of CD4 cell count. Analyses from Uganda are presented here. MethodsIn this cross-sectional, observational study, patients on first-line antiretroviral therapy (ART) (efavirenz or nevirapine+zidovudine/lamivudine) from Kayunga District Hospital and Kagulamira Health Center were randomly selected for a study visit that included determination of viral load (HIV-1 RNA), CD4 cell count and clinical chemistry tests. Subjects were recruited by time on treatment: 6-12, 13-24 or >24 months. Logistic regression modelling identified predictors of virological suppression. Linear regression modelling identified predictors of CD4 cell count recovery on ART. ResultsWe found that 85.2% of 325 subjects were virologically suppressed (viral load<47 HIV-1 RNA copies/ml). There was no difference in the proportion of virologically suppressed subjects by time on treatment, yet CD4 counts were higher in each successive stratum. Women had higher median CD4 counts than men overall (406 vs. 294 cells/L, respectively; P<0.0001) and in each time-on-treatment stratum. In a multivariate logistic regression model, predictors of virological suppression included efavirenz use [odds ratio (OR) 0.47; 95% confidence interval (CI) 0.22-1.02; P=0.057], lower cost of clinic visits (OR 0.815; 95% CI 0.66-1.00; P=0.05), improvement in CD4 percentage (OR 1.06; 95% CI 1.014-1.107; P=0.009), and care at Kayunga vs.Kangulamira (OR 0.47; 95% CI 0.23-0.92; P=0.035). In a multivariate linear regression model of covariates associated with CD4 count recovery, time on highly active antiretroviral therapy (ART) (P<0.0001), patient satisfaction with care (P=0.038), improvements in total lymphocyte count (P<0.0001) and haemoglobin concentration (P=0.05) were positively associated, whereas age at start of ART (P=0.0045) was negatively associated with this outcome. ConclusionsHigh virological suppression rates are achievable on first-line ART in Uganda. The odds of virological suppression were positively associated with efavirenz use and improvements in CD4 cell percentage and total lymphocyte count and negatively associated with the cost of travel to the clinic. CD4 cell reconstitution was positively associated with CD4 count at study visit, time on ART, satisfaction with care at clinic, haemoglobin concentration and total lymphocyte count and negatively associated with age. C1 [Crawford, K. W.; Liu, M.; Hamm, T. E.] Walter Reed Army Inst Res, Global Hlth Programs, US Mil HIV Res Program MHRP, Bethesda, MD USA. [Crawford, K. W.; Liu, M.; Hamm, T. E.] Henry M Jackson Fdn Adv Mil Med, Bethesda, MD USA. [Wakabi, S.; Magala, F.; Kibuuka, H.] Makerere Univ, Walter Reed Program, Kampala, Uganda. RP Crawford, KW (reprint author), 100 Seaton Pl NW,First floor, Washington, DC 20001 USA. EM kwcrawford1@gmail.com FU Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. [W81XWH-07-2-0067]; US Department of Defense (DoD) [W81XWH-07-2-0067]; US President's Emergency Plan for AIDS Relief (PEPFAR) FX This work was supported by a cooperative agreement (W81XWH-07-2-0067) between the Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., and the US Department of Defense (DoD). This research was funded, in part, by the US President's Emergency Plan for AIDS Relief (PEPFAR). The views expressed are those of the authors and should not be construed to represent the positions of the US Army or DoD. NR 56 TC 8 Z9 8 U1 1 U2 2 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1464-2662 EI 1468-1293 J9 HIV MED JI HIV Med. PD FEB PY 2015 VL 16 IS 2 BP 95 EP 104 DI 10.1111/hiv.12177 PG 10 WC Infectious Diseases SC Infectious Diseases GA CA2AW UT WOS:000348712300004 PM 25124078 ER PT J AU von Schweinitz, BA De Lorenzo, RA Cuenca, PJ Anschutz, RL Allen, PB AF von Schweinitz, Benjamin A. De Lorenzo, Robert A. Cuenca, Peter J. Anschutz, Richard L. Allen, Paul B. TI Does a non-invasive hemoglobin monitor correlate with a venous blood sample in the acutely ill? SO INTERNAL AND EMERGENCY MEDICINE LA English DT Article DE Point-of-care; Hemoglobin; Analysis; Emergency care; Human ID PULSE CO-OXIMETRY; ACCURACY; SURGERY; CARE; HEMOCUE(R); SPHB AB Non-invasive hemoglobin measuring technology has potential for rapid, portable, and accurate way of providing identification of blood loss or anemia. Our objective is to determine if this technology is reliable in critically ill patients presenting to the Emergency Department. Prospective cross-sectional observational study was done at an urban level-one trauma center, 135 subjects were conveniently sampled, suspected of having active bleeding, sepsis, or other critically ill condition. Non-invasive measurements with Masimo (Irvine, CA, USA) Radical-7 and Rad-57 hemoglobin monitors were compared with the Beckman-Coulter LH-550 (Brea, CA, USA) clinical laboratory blood cell analyzer. The primary outcome was the relationship of the non-invasive device to the clinical laboratory results. Secondary evaluations included the effect of pulse rate, systolic BP, respiratory rate, temperature, capillary refill, skin color, nail condition, extremity movement. The Radical-7 was able to capture reading in 78 % (88/113) of subjects, and the Rad-57 in 65 % (71/110) of subjects. The correlation (R-2) of the device Hb was 0.69 and 0.67 (p < 00.01) for the Radical-7 and Rad-57, respectively. The coefficient of variation for the Radical-7 was 18 %, and for the Rad57 it was 13 %. Univariate analysis shows none of the observed factors is associated with the difference values between the device Hb and laboratory Hb. Our results show that Radical-7 and Rad-57 devices do not report readings in 29 % of patients and accuracy is significantly lower than reported by the manufacturer with over 50 % of readings falling outside of +/- A 1 g/dL. We determined that none of the several potential factors examined are associated with the degree of device accuracy. C1 [von Schweinitz, Benjamin A.; Cuenca, Peter J.; Anschutz, Richard L.; Allen, Paul B.] San Antonio Mil Med Ctr, Dept Emergency Med, Jbsa Ft Sam Houston, TX 78234 USA. [von Schweinitz, Benjamin A.] San Antonio Uniformed Serv Hlth Educ Consortium, Jbsa Ft Sam Houston, TX 78234 USA. [De Lorenzo, Robert A.] US Army Inst Surg Res, Tact Combat Casualty Care Res Program, Jbsa Ft Sam Houston, TX 78234 USA. [De Lorenzo, Robert A.; Cuenca, Peter J.] Univ Texas Hlth Sci Ctr San Antonio, Dept Emergency Med, San Antonio, TX 78229 USA. RP von Schweinitz, BA (reprint author), San Antonio Uniformed Serv Hlth Educ Consortium, 3551 Roger Brooke Dr, Jbsa Ft Sam Houston, TX 78234 USA. EM Benjamin.vonschweinitz@gmail.com; Robert.A.DeLorenzo.mil@mail.mil FU Telemedicine and Advance Technology Research Center, US Army Medical Research and Material Command, Fort Detrick, MD, USA FX This study was supported by a grant from the Telemedicine and Advance Technology Research Center, US Army Medical Research and Material Command, Fort Detrick, MD 21702 USA. Thanks to James K. Aden, PhD for his thoughtful statistical analysis. Special thanks to Olivia E. Dominguez and Vanessa N. Ellis for their tireless efforts as research technicians. NR 19 TC 3 Z9 3 U1 1 U2 2 PU SPRINGER-VERLAG ITALIA SRL PI MILAN PA VIA DECEMBRIO, 28, MILAN, 20137, ITALY SN 1828-0447 EI 1970-9366 J9 INTERN EMERG MED JI Intern. Emerg. Med. PD FEB PY 2015 VL 10 IS 1 BP 55 EP 61 DI 10.1007/s11739-014-1129-9 PG 7 WC Medicine, General & Internal SC General & Internal Medicine GA CA6BK UT WOS:000348993200010 PM 25322853 ER PT J AU Sajo, E Wallace, W Lumley, A Heimbuch, B Donahue, K Nielsen, B Owens, J Wander, J AF Sajo, Erno Wallace, William Lumley, April Heimbuch, Brian Donahue, Kristian Nielsen, Bruce Owens, Jeffery Wander, Joseph TI Capture of aerosolized spores from air streams impinging onto fabrics SO JOURNAL OF AEROSOL SCIENCE LA English DT Article DE Aerosol; Airlock; Boundary layer; Deposition; Modeling; Spores ID DEPOSITION; RECOVERY; SURFACES; DRY AB The zero-volume airlock concept minimizes the volume of air in and transiting through the airlock by effusing air from the clean area through spaces between deformable air bladders. An individual transiting through the airlock into a shelter displaces the bladders and creates ephemeral regions of varying dimensions and air velocities, which affect deposition and reaerosolization of particles. Properties of the aerosols and bladder surfaces are also influences, so the airlock may be treated to shed or retain particles and possibly to promote decontamination of them; the uniform material determines the protection from or exposure to these particles that the wearer experiences. To initiate evolution of a predictive computational model for the deposition and disposition of airborne particles in an airlock, this study presents measurements of deposition rates of Bacillus atrophaeus spores, a common simulant for anthrax spores, on a variety of fabrics as a function of airspeed and angle of incidence at similar to 22 degrees C and similar to 55% RH in a laboratory-scale aerosol tunnel. A computational model using inert surface properties consistently underpredicted experimental results by a factor of 2-10, suggesting that the variation in results across the test panel can be exploited to generate empirical parameters that can be substituted into the model to improve its predictive capability. Factors and possible approaches to computational descriptions are considered. Published by Elsevier Ltd. C1 [Sajo, Erno] Univ Massachusetts, Dept Phys, Lowell, MA 01854 USA. [Wallace, William; Lumley, April; Heimbuch, Brian] Appl Res Associates Inc, Panama City, FL 32401 USA. [Donahue, Kristian] US Army, RDECOM, Natick, MA 01760 USA. [Nielsen, Bruce] Air Force Res Lab, Tyndall AFB, FL 32403 USA. [Owens, Jeffery; Wander, Joseph] Air Force Civil Engineer Ctr, Tyndall AFB, FL 32403 USA. RP Wander, J (reprint author), Air Force Civil Engineer Ctr, Tyndall AFB, FL 32403 USA. EM joseph.wander@us.af.mil FU Defense Threat Reduction Agency [CA08PRO0002] FX The authors thank Warwick Mills for providing the test fabrics via the Army Natick Soldier RD&E Center, Karen Farrington for the high-magnification EM images, and the Defense Threat Reduction Agency for funding this effort as part of Project CA08PRO0002, Reactive Airlock Technologies for Collective Protection Applications. The literature searches that support this effort were performed by staff of the Technical Information Center at Tyndall AFB, for whose assistance we are greatly appreciative. NR 22 TC 1 Z9 1 U1 0 U2 5 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0021-8502 EI 1879-1964 J9 J AEROSOL SCI JI J. Aerosol. Sci. PD FEB PY 2015 VL 80 BP 75 EP 85 DI 10.1016/j.jaerosci.2014.10.010 PG 11 WC Engineering, Chemical; Engineering, Mechanical; Environmental Sciences; Meteorology & Atmospheric Sciences SC Engineering; Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences GA CA8TD UT WOS:000349192900006 ER PT J AU Colombo, CJ Stachura, M Wood, E George, A Broughton, R AF Colombo, C. J. Stachura, M. Wood, E. George, A. Broughton, R. TI AUTOMATED URINE FLOW RATE AND VOLUME MEASUREMENT: VALIDATION OF A NOVEL SYSTEM SO JOURNAL OF INVESTIGATIVE MEDICINE LA English DT Meeting Abstract CT Southern Regional Meeting of the American-Federation-for-Medical-Research CY FEB 26-28, 2015 CL New Orleans, LA SP Amer Federat Med Res C1 [Colombo, C. J.; George, A.; Broughton, R.] Dwight D Eisenhower Army Med Ctr, Ft Gordon, GA USA. [Stachura, M.; Wood, E.] Georgia Regents Univ, Augusta, GA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1081-5589 EI 1708-8267 J9 J INVEST MED JI J. Invest. Med. PD FEB PY 2015 VL 63 IS 2 MA 148 BP 367 EP 367 PG 1 WC Medicine, General & Internal; Medicine, Research & Experimental SC General & Internal Medicine; Research & Experimental Medicine GA CA0GM UT WOS:000348595000159 ER PT J AU Rudy, RQ Smith, GL DeVoe, DL Polcawich, RG AF Rudy, Ryan Q. Smith, Gabriel L. DeVoe, Don L. Polcawich, Ronald G. TI Millimeter-Scale Traveling Wave Rotary Ultrasonic Motors SO JOURNAL OF MICROELECTROMECHANICAL SYSTEMS LA English DT Article DE Micromotors; piezoelectric films; traveling wave devices; PZT ceramics ID PZT AB Bidirectional rotary motion of a millimeter-scale traveling wave ultrasonic motor is demonstrated using solution-deposited thin-film lead zirconate titanate and wafer-scale microelectromechanical system fabrication techniques. Rotation speeds of a motor 3 mm in diameter have been characterized up to 2000 r/min as a function of voltage, phase, and frequency, with power consumption less than 4 mW. Frequency characterization shows no nonlinear behavior, while phase characterization shows that motion can be generated with a single source drive. Furthermore, imprint in the piezoelectric response was exploited to achieve higher speeds, starting voltages lower than 4 V, and demonstration of a 2-mm diameter motor up to 1730 r/min. Design and fabrication of the motors are also presented. [2013-0032] C1 [Rudy, Ryan Q.; Smith, Gabriel L.; Polcawich, Ronald G.] US Army Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA. [Rudy, Ryan Q.; DeVoe, Don L.] Univ Maryland, Dept Mech Engn, College Pk, MD 20742 USA. RP Rudy, RQ (reprint author), US Army Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA. EM ryan.q.rudy.ctr@mail.mil; gabriel.l.smith.12.civ@mail.mil; ddev@umd.edu; ronald.g.polcawich.civ@mail.mil RI DeVoe, Don/A-2891-2011 OI DeVoe, Don/0000-0002-7740-9993 FU Science, Mathematics, and Research for Transformation (SMART) Program FX The work of R. Q. Rudy was supported by the Science, Mathematics, and Research for Transformation (SMART) Program. Subject Editor K. F. Bohringer. NR 23 TC 5 Z9 5 U1 11 U2 41 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1057-7157 EI 1941-0158 J9 J MICROELECTROMECH S JI J. Microelectromech. Syst. PD FEB PY 2015 VL 24 IS 1 BP 108 EP 114 DI 10.1109/JMEMS.2014.2317778 PG 7 WC Engineering, Electrical & Electronic; Nanoscience & Nanotechnology; Instruments & Instrumentation; Physics, Applied SC Engineering; Science & Technology - Other Topics; Instruments & Instrumentation; Physics GA CA8JG UT WOS:000349164300014 ER PT J AU Scott, AM Burns, EA Lafferty, BJ Hill, FC AF Scott, Andrea Michalkova Burns, Elizabeth A. Lafferty, Brandon J. Hill, Frances C. TI Theoretical predictions of thermodynamic parameters of adsorption of nitrogen containing environmental contaminants on kaolinite SO JOURNAL OF MOLECULAR MODELING LA English DT Article DE Binding; Clay; Distribution; Modeling; Nitroaromatic ID DENSITY-FUNCTIONAL THEORY; SPACE GAUSSIAN PSEUDOPOTENTIALS; AB-INITIO; CLAY-MINERALS; SUBSTITUTED NITROBENZENES; ORGANOCHLORINE PESTICIDES; NITROAROMATIC EXPLOSIVES; NONCOVALENT INTERACTIONS; CARBONACEOUS MATERIALS; SILICA SURFACES AB In this study thermodynamic parameters of adsorption of nitrogen containing environmental contaminants ( NCCs, 2,4,6, trinitrotoluene (TNT), 2,4-dinitrotoluene (DNT), 2,4-dinitroanisole (DNAN), and 3-one-1,2,4-triazol-5-one (NTO)) interacting with the tetrahedral and octahedral surfaces of kaolinite were predicted. Adsorption complexes were investigated using a density functional theory and both periodic and cluster approach. The complexes, modeled using the periodic boundary conditions approach, were fully optimized at the BLYP-D2 level to obtain the structures and adsorption energies. The relaxed kaolinite-NCCs structures were used to prepare cluster models to calculate thermodynamic parameters and partition coefficients at the M06-2X-D3 and BLYP-D2 levels from the gas phase. The entropy effect on the Gibbs free energies of adsorption of NCCS on kaolinite was also studied and compared with available experimental data. The results showed that in all calculated models, the NCCs molecules are physisorbed and they favor a parallel orientation toward both kaolinite surfaces. It was found that all calculated NCCs compounds are more stable on the octahedral than on the tetrahedral surface of kaolinite. The Gibbs free energies and partition coefficients were also predicted for interactions of NCCs with Na-kaolinite from aqueous solution. Calculations revealed adsorption of NCCs is effective from the gas phase on both cation free kaolinite surfaces and on Na-kaolinite from aqueous solution at room temperature. Theoretical data were validated against experimental results, and the reasons for small differences between calculated and measured partition coefficients are discussed. C1 [Scott, Andrea Michalkova; Lafferty, Brandon J.; Hill, Frances C.] US Army Engn Res & Dev Ctr ERDC, Vicksburg, MS 39180 USA. [Burns, Elizabeth A.] Badger Tech Serv LLC, Vicksburg, MS 39180 USA. RP Scott, AM (reprint author), US Army Engn Res & Dev Ctr ERDC, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM andrea.m.scott@usace.army.mil FU Environmental Quality Technology Program of the United States Army Corps of Engineers by the US Army ERDC FX This work was facilitated by support from the High Performance Computing Distributed Shared Resource Center at the ERDC (Vicksburg, MS). The use of trade, product, or firm names in this report is for descriptive purposes only and does not imply endorsement by the U.S. Government. Results in this study were funded and obtained from research conducted under the Environmental Quality Technology Program of the United States Army Corps of Engineers by the US Army ERDC. Permission was granted by the Chief of Engineers to publish this information. The findings of this report are not to be construed as an official Department of the Army position unless so designated by other authorized documents. NR 87 TC 2 Z9 2 U1 1 U2 18 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1610-2940 EI 0948-5023 J9 J MOL MODEL JI J. Mol. Model. PD FEB PY 2015 VL 21 IS 2 AR 21 DI 10.1007/s00894-015-2577-5 PG 16 WC Biochemistry & Molecular Biology; Biophysics; Chemistry, Multidisciplinary; Computer Science, Interdisciplinary Applications SC Biochemistry & Molecular Biology; Biophysics; Chemistry; Computer Science GA CA5XO UT WOS:000348981900002 PM 25620422 ER PT J AU Penn-Barwell, JG Baker, B Wenke, JC AF Penn-Barwell, Jowan G. Baker, Brett Wenke, Joseph C. TI Local Bismuth Thiols Potentiate Antibiotics and Reduce Infection in a Contaminated Open Fracture Model SO JOURNAL OF ORTHOPAEDIC TRAUMA LA English DT Article DE open fractures; infection; injury; biofilm; antibiotics; debridement; wounds; bismuth thiols; orthopaedic medical device; osteosynthesis; bismuth ID PSEUDOMONAS-AERUGINOSA; IN-VITRO; POLYURETHANE SCAFFOLDS; ANTIBACTERIAL ACTIVITY; SEGMENTAL DEFECT; RAT FEMUR; BIOFILMS; WOUNDS; COMBAT; POLYSACCHARIDE AB Objective: This proof-of-concept study tested the hypothesis that combining bismuth thiols (BTs) with systemic antibiotics will more effectively reduce infection in an animal model of contaminated open fracture than systemic antibiotics alone. Methods: An implant-stabilized segmental defect rat model was contaminated with Staphylococcus aureus and then treated with surgical debridement 6 hours after injury and 3 days of systemic cefazolin. A single dose of BTs suspended in a hydrogel was administered to the wound immediately after debridement. After 14 days, the bone and implant were harvested for microbiological analysis. Results: A single local dose of 0.05 mg of BT (MB-8-2), when combined with systemically administered cefazolin, decreased infection, without any noticeable local or systemic toxicity, from 60% to 10% (P = 0.002), with only 0.02% of the recovered bacteria quantity of the cefazolin-only group (P < 0.001). Higher doses were less effective and caused side-effects. Conclusions: BTs administered locally to infected open fracture wounds at an appropriate dose potentiate the effect of systemically administered antibiotics and reduce infection rate and bacteria quantity associated with bone and orthopaedic implants. Local delivery of BTs is a promising strategy for increasing the efficacy of systemically administered antibiotics in preventing and treating infections of open fractures. C1 [Penn-Barwell, Jowan G.; Wenke, Joseph C.] US Army, Inst Surg Res, Extrem Trauma Bone Grp, San Antonio, TX 78234 USA. [Penn-Barwell, Jowan G.] Royal Ctr Def Med, Acad Dept Mil Surg & Trauma, Birmingham, W Midlands, England. [Baker, Brett] Microbion Biosci Corp, Bozeman, MT USA. RP Wenke, JC (reprint author), US Army, Inst Surg Res, Extrem Trauma Bone Grp, 3698 Chambers Pass, Ft Sam Houston, TX 78234 USA. EM joseph.c.wenke.civ@mail.mil NR 38 TC 1 Z9 2 U1 1 U2 7 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0890-5339 EI 1531-2291 J9 J ORTHOP TRAUMA JI J. Orthop. Trauma PD FEB PY 2015 VL 29 IS 2 BP E73 EP E78 PG 6 WC Orthopedics; Sport Sciences SC Orthopedics; Sport Sciences GA CA3TH UT WOS:000348828500011 PM 24978943 ER PT J AU Song, DJ Cook, JB Krul, KP Bottoni, CR Rowles, DJ Shaha, SH Tokish, JM AF Song, Daniel J. Cook, Jay B. Krul, Kevin P. Bottoni, Craig R. Rowles, Douglas J. Shaha, Steve H. Tokish, John M. TI High frequency of posterior and combined shoulder instability in young active patients SO JOURNAL OF SHOULDER AND ELBOW SURGERY LA English DT Article DE Shoulder instability; posterior shoulder instability; combined shoulder instability ID GLENOID LABRUM; CIRCUMFERENTIAL LESIONS; ARTHROSCOPIC REPAIR; FOLLOW-UP; MANAGEMENT; DIAGNOSIS; PATHOLOGY; MRI AB Objective: The purpose of this study was to describe the epidemiology and demographics of surgically treated shoulder instability stratified by direction. We hypothesized that there would be an increased frequency of posterior and combined shoulder instability in our population compared with published literature. Secondarily, we assessed preoperative magnetic resonance imaging (MRI) reports to determine how accurately they detected the pathology addressed at surgery. Materials and methods: A retrospective review was conducted at a single facility during a 46-month period. The study included all patients who underwent an operative intervention for shoulder instability. The instability in each case was characterized as isolated anterior, isolated posterior, or combined, according to pathologic findings confirmed at arthroscopy. The findings were retrospectively compared with official MRI reports to determine the accuracy of MRI in characterizing the clinically and operatively confirmed diagnosis. Results: A consecutive series of 231 patients (221 men, 10 women) underwent stabilization for shoulder instability over 46 months. Patients were a mean age of 26.0 years. There were 132 patients (57.1%) with isolated anterior instability, 56 (24.2%) with isolated posterior instability, and 43 18.6%) with combined instability. Overall, MRI findings completely characterized the clinical diagnosis and arthroscopic pathology in 149 of 219 patients (68.0%). Conclusion: The rate of posterior and combined instability in an active population is more common than has been previously reported, making up more than 40% of operatively treated instability, including a previously unreported incidence of 19% for combined instabilities. In addition, MRI was often incomplete or inaccurate in detecting the pathology eventually treated at surgery. Published by Elsevier Inc. on behalf of Journal of Shoulder and Elbow Surgery Board of Trustees. C1 [Song, Daniel J.] Landstuhl Reg Med Ctr, Orthopaed Surg Serv, D-09180 Landstuhl, Germany. [Cook, Jay B.; Krul, Kevin P.; Bottoni, Craig R.; Rowles, Douglas J.; Tokish, John M.] Tripler Army Med Ctr, Orthoped Surg Serv, Honolulu, HI 96859 USA. [Shaha, Steve H.] Univ Utah, Ctr Publ Policy & Adm, Salt Lake City, UT USA. [Shaha, Steve H.] Allscripts, Chicago, IL USA. [Tokish, John M.] Steadman Hawkins Clin Carolinas, Greenville, SC USA. RP Song, DJ (reprint author), Landstuhl Reg Med Ctr, Orthopaed Surg Serv, CMR 402 Box 445,APO,AE, D-09180 Landstuhl, Germany. EM song_daniel@hotmail.com NR 23 TC 8 Z9 8 U1 0 U2 1 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 1058-2746 J9 J SHOULDER ELB SURG JI J. Shoulder Elbow Surg. PD FEB PY 2015 VL 24 IS 2 BP 186 EP 190 DI 10.1016/j.jse.2014.06.053 PG 5 WC Orthopedics; Sport Sciences; Surgery SC Orthopedics; Sport Sciences; Surgery GA AY7DJ UT WOS:000347721200010 PM 25219471 ER PT J AU Swab, JJ Tice, J Wereszczak, AA Kraft, RH AF Swab, Jeffrey J. Tice, Jason Wereszczak, Andrew A. Kraft, Reuben H. TI Fracture Toughness of Advanced Structural Ceramics: Applying ASTM C1421 SO JOURNAL OF THE AMERICAN CERAMIC SOCIETY LA English DT Article ID TOUGHENED SILICON-NITRIDE; SUBCRITICAL CRACK-GROWTH; EDGE-PRECRACKED-BEAM; R-CURVE BEHAVIOR; SURFACE-CRACK; FLEXURE METHOD; RESISTANCE; ALUMINA; SHAPE; SIZE AB The three methods of determining the quasi-static Mode I fracture toughness (K-Ic) (surface crack in flexureSC, single-edge precracked beamPB, and chevron-notched beamVB) found in ASTM C1421 were applied to a variety of advanced ceramic materials. All three methods produced valid and comparable K-Ic values for the Al2O3, SiC, Si3N4, and SiAlON ceramics examined. However, not all methods could successfully be applied to B4C, ZrO2, and WC ceramics due to a variety of material factors. The coarse-grained microstructure of one B4C hindered the ability to observe and measure the precracks generated in the SC and PB methods while the transformation toughening in the ZrO2 prevented the formation of the SC and PB precracks and thus made it impossible to use either method on this ceramic. The high strength and elastic modulus of the WC made it impossible to achieve stable crack growth using the VB method because the specimen stored a tremendous amount of energy prior to fracture. Even though these methods have passed the rigors of the standardization process there are still some issues to be resolved when the methods are applied to certain classes of ceramics. It is recommended that, when appropriate, at least two of these methods be employed to determine the K-Ic, especially when a new or unfamiliar ceramic is being evaluated. C1 [Swab, Jeffrey J.; Tice, Jason; Kraft, Reuben H.] Army Res Lab, Aberdeen Proving Ground, MD 21005 USA. [Wereszczak, Andrew A.] Oak Ridge Natl Lab, Oak Ridge, TN 37831 USA. [Tice, Jason] Univ Maryland Baltimore Cty, Baltimore, MD 21228 USA. [Tice, Jason; Kraft, Reuben H.] Harford Community Coll, Bel Air, MD USA. RP Swab, JJ (reprint author), Army Res Lab, Aberdeen Proving Ground, MD 21005 USA. EM jeffrey.j.swab.civ@mail.mil RI Wereszczak, Andrew/I-7310-2016 OI Wereszczak, Andrew/0000-0002-8344-092X FU US Army Research Laboratory (USARL) FX Work performed while an undergraduate student at the University of Maryland Baltimore County and with support by an appointment to the Research Participation Program at the US Army Research Laboratory (USARL) administered by the Oak Ridge Institute for Science and Education through an interagency agreement between USARL and the US Department of Energy. NR 31 TC 1 Z9 1 U1 1 U2 30 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0002-7820 EI 1551-2916 J9 J AM CERAM SOC JI J. Am. Ceram. Soc. PD FEB PY 2015 VL 98 IS 2 BP 607 EP 615 DI 10.1111/jace.13293 PG 9 WC Materials Science, Ceramics SC Materials Science GA CA1HC UT WOS:000348662400040 ER PT J AU Edwards, MJ Lustik, MB Clark, ME Creamer, KM Tuggle, D AF Edwards, Mary J. Lustik, Michael B. Clark, Margaret E. Creamer, Kevin M. Tuggle, David TI The effects of balanced blood component resuscitation and crystalloid administration in pediatric trauma patients requiring transfusion in Afghanistan and Iraq 2002 to 2012 SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY LA English DT Article DE Pediatric; hemorrhage; resuscitation; crystalloid; transfusion ID MASSIVE TRANSFUSION; WHOLE-BLOOD; INJURIES; CHILDREN; THERAPY; PROMMTT AB BACKGROUND: Component balanced resuscitation and avoidance of crystalloids in traumatically injured adults requiring massive transfusion are beneficial. Evidence for children is lacking. METHODS: After institutional review board approval was obtained, the Department of Defense Trauma Database identified 1,311 injured children 14 years or younger requiring transfusion after an injury and admitted to a deployed US military hospital from 2002 to 2012. Logistic regression determined risk factors for high-volume (>= 40 mL/kg) or massive (>= 70 mL/kg) transfusions. The effects of crystalloid and balanced component resuscitation in the first 24 hours were assessed. RESULTS: Nine hundred seven patients had recorded data sufficient for analysis. Two hundred twenty-four children received high-volume transfusion, and 77 received massive transfusions. Mortality was significantly higher for massive transfusions and high-volume transfusions than others (25% vs. 10% and 19% vs. 9%, respectively). Age of less than 4 years, penetrating injury, and Injury Severity Score (ISS) greater than 15 were associated with high-volume transfusions; an ISS greater than 15 and penetrating injury were associated with massive transfusions. Increased crystalloid administration showed a significant positive association with hospital days and intensive care unit days for both massive and high-volume transfusions, as well as a significant positive association with increased ventilator days in patients with high-volume transfusions. Balanced component resuscitation was not associated with improved measured outcomes and was independently associated with a higher mortality when all transfused patients were considered. CONCLUSION: In this cohort, heavy reliance on crystalloid for resuscitation had an adverse effect on outcomes. Balanced component resuscitation did not improve outcomes and was associated with higher mortality when all transfused patients were considered. Further study is needed regarding efficacy and clinical triggers for the implementation of massive transfusion in children. (Copyright (C) 2015 Wolters Kluwer Health, Inc. All rights reserved.) LEVEL OF EVIDENCE: Prognostic study, level IV. C1 [Edwards, Mary J.] San Antonio Mil Med Ctr, Dept Surg, San Antonio, TX 78234 USA. [Tuggle, David] UT Southwestern, Dept Trauma, Dell Childrens Med Ctr, Austin, TX USA. [Lustik, Michael B.] Tripler Army Med Ctr, Dept Clin Invest, Honolulu, HI 96859 USA. [Clark, Margaret E.] Tripler Army Med Ctr, Dept Surg, Honolulu, HI 96859 USA. [Creamer, Kevin M.] Childrens Natl Med Ctr, Hospitalist Div, Washington, DC 20010 USA. RP Edwards, MJ (reprint author), San Antonio Mil Med Ctr, Dept Surg, 3551 Roger Brooke Dr, San Antonio, TX 78234 USA. EM mary.j.edwards.mil@mail.mil NR 20 TC 2 Z9 2 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 2163-0755 EI 2163-0763 J9 J TRAUMA ACUTE CARE JI J. Trauma Acute Care Surg. PD FEB PY 2015 VL 78 IS 2 BP 330 EP 335 DI 10.1097/TA.0000000000000469 PG 6 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA CA3TF UT WOS:000348828300017 PM 25757119 ER PT J AU Roy, TC Ritland, BM Sharp, MA AF Roy, Tanja C. Ritland, Bradley M. Sharp, Marilyn A. TI A Description of Injuries in Men and Women While Serving in Afghanistan SO MILITARY MEDICINE LA English DT Article ID LOW-BACK-PAIN; OPERATIONS IRAQI FREEDOM; FEMALE ARMY TRAINEES; RISK-FACTORS; ENDURING FREEDOM; PHYSICAL-FITNESS; US ARMY; CONSTRUCTION ENGINEERS; OUTPATIENT VISITS; TRAINING-PROGRAM AB Musculoskeletal injuries (MSIs) are the most common cause of ambulatory visits in the deployed setting. Research done on deployed populations have focused mostly on men. The purpose of this retrospective cohort study was to describe physical demands and MSIs among male and female soldiers in a Brigade Combat Team during a 12-month deployment to Afghanistan. Data on occupational tasks and injuries were collected from the infantry and brigade support battalions. Out of 57 women, 22 had MSIs (39%) and for the 536 men, 120 (22%) had MSIs resulting in limited duty. The average limited duty was 7.5 and 13 days/injury for women and men, respectively. The most commonly injured body region for the men was the low back (32%) and the low back (22%) and foot and ankle (22%) for women. The activity associated with MSI for women was physical training (25%) and for men it was contact with the enemy (23%). Physically demanding duties, more distance walked, and heavier average load and objects lifted all increased the risk of injury in women. Only lifting heavier weights increased the risk in men. The women appear to have less tolerance to physically demanding work such than their male counterparts. C1 [Roy, Tanja C.; Ritland, Bradley M.; Sharp, Marilyn A.] US Army, Environm Med Res Inst, Natick, MA 01760 USA. RP Roy, TC (reprint author), US Army, Environm Med Res Inst, 15 Kansas St, Natick, MA 01760 USA. FU Soldiers of the Infantry Battalion [4/23]; Brigade Support Battalion, Fort Lewis, Washington; U.S. Army Medical Research and Materiel Command under Task Area S FX The authors would like to thank the Soldiers of the 4/23 Infantry Battalion and 402nd Brigade Support Battalion, Fort Lewis, Washington, for their support and assistance with this study. This research was funded by the U.S. Army Medical Research and Materiel Command under Task Area S. NR 34 TC 3 Z9 3 U1 1 U2 3 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD FEB PY 2015 VL 180 IS 2 BP 126 EP 131 DI 10.7205/MILMED-D-14-00321 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA CA7MR UT WOS:000349101900002 PM 25643377 ER PT J AU Chandrasekera, RM Lesho, EP Chukwuma, U Cummings, JF Waterman, PE AF Chandrasekera, Ruvani M. Lesho, Emil P. Chukwuma, Uzo Cummings, James F. Waterman, Paige E. TI The State of Antimicrobial Resistance Surveillance in the Military Health System: A Review of Improvements Made in the Last 10 Years and Remaining Surveillance Gaps SO MILITARY MEDICINE LA English DT Review ID METALLO-BETA-LACTAMASE; ANTIBIOTIC-RESISTANCE; ACINETOBACTER-BAUMANNII; CARBAPENEM-RESISTANT; PROVIDENCIA-STUARTII; STAPHYLOCOCCUS-AUREUS; KLEBSIELLA-PNEUMONIAE; ROUTINE SURVEILLANCE; WOUND INFECTIONS; CLINICAL ISOLATE AB During a military public health laboratory symposium held in 1999, concerns were raised that the military health system lacked a standardized antimicrobial resistance (AMR) surveillance system that allowed comparison of data across sites, investigation of trends, and understanding of resistance mechanisms. The purpose of this review was to assess if current AMR activities in the military health system have addressed the aforementioned gaps. It was determined that much progress has already been made within the Department of Defense with respect to monitoring and understanding AMR through initiatives such as the Antimicrobial Resistance Monitoring and Research Program-a strong Department of Defense-wide surveillance program. These surveillance efforts can be made more robust through harmonization of testing and reporting structures across military treatment facilities, and by encouraging military treatment facility participation. C1 [Chandrasekera, Ruvani M.; Cummings, James F.; Waterman, Paige E.] Armed Forces Hlth Surveillance Ctr, Silver Spring, MD 20910 USA. [Lesho, Emil P.] Walter Reed Army Inst Res, Multidrug Resistant Organism Rep & Surveillance N, Silver Spring, MD 20910 USA. [Chukwuma, Uzo] Navy & Marine Corps Public Hlth Ctr, EpiData Ctr, Portsmouth, VA 23708 USA. RP Chandrasekera, RM (reprint author), Armed Forces Hlth Surveillance Ctr, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. NR 46 TC 1 Z9 1 U1 2 U2 4 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD FEB PY 2015 VL 180 IS 2 BP 145 EP 150 DI 10.7205/MILMED-D-14-00297 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA CA7MR UT WOS:000349101900006 PM 25643381 ER PT J AU Kim, HC Takhampunya, R Tippayachai, B Chong, ST Park, JY Kim, MS Seo, HJ Yeh, JY Lee, WJ Lee, DK Klein, TA AF Kim, Heung Chul Takhampunya, Ratree Tippayachai, Bousaraporn Chong, Sung-Tae Park, Jee-Yong Kim, Myung-Soon Seo, Hyun-Ji Yeh, Jung-Yong Lee, Won-Ja Lee, Dong-Kyu Klein, Terry A. TI Japanese Encephalitis Virus in Culicine Mosquitoes (Diptera: Culicidae) of the Republic of Korea, 2008-2010 SO MILITARY MEDICINE LA English DT Article ID SOUTH-KOREA; GENOTYPE V; INFECTION; SURVEILLANCE; TRANSMISSION; IMMUNIZATION; AMERICANS; THAILAND; ANTIBODY; FUTURE AB A total of 150,805 culicine female mosquitoes were captured by Mosquito Magnet, black light, and New Jersey light traps, and at resting collections in the Republic of Korea from 2008 to 2010 as part of the U. S. Forces Korea malaria and Japanese surveillance programs. Mosquitoes were identified and culicine mosquitoes placed in pools of up to 30 mosquitoes each, by species and date of collection, and screened for flaviviruses using a reverse transcription-polymerase chain reaction assay. A total of 98/6,845 (1.4%) pools were positive by reverse transcription-polymerase chain reaction for Japanese encephalitis virus (JEV). A total of 92/2,031 (4.5%) pools of Culex tritaeniorhynchus were positive for JEV and accounted for 93.9% (92/98) of all JEV positive pools. A total of 4/804 (0.5%) and 2/175 (1.1%) pools of C. pipiens and C. bitaeniorhynchus, respectively, were positive for JEV. The JEV maximum likelihood estimations (estimated number of viral RNA positive mosquitoes per 1,000) for C. tritaeniorhynchus, C. bitaeniorhynchus, and C. pipiens were 1.71, 1.02, and 0.36 respectively. JEV is a severe health threat for local populations and of significant concern for nonimmune (unvaccinated) U.S. soldiers, civilians, and family members deployed to the Republic of Korea. C1 [Takhampunya, Ratree; Tippayachai, Bousaraporn] Armed Forces Res Inst Med Sci, Dept Entomol, Bangkok 10400, Thailand. [Park, Jee-Yong; Kim, Myung-Soon; Seo, Hyun-Ji] Anim & Plant Quarantine Agcy, Foreign Anim Dis Div, Anyang 430824, Gyeonggi, South Korea. [Yeh, Jung-Yong] Univ Incheon, Coll Life Sci & Bioengn, Div Life Sci, Inchon 406772, South Korea. [Lee, Won-Ja] Korea Ctr Dis Control & Prevent, NIH, Chungbuk 363951, South Korea. [Lee, Dong-Kyu] Kosin Univ, Dept Hlth & Environm, Pusan 606701, South Korea. [Klein, Terry A.] Publ Hlth Command Reg Pacific, Camp Zama, Japan. [Klein, Terry A.] Force Hlth Protect & Prevent Med, Seoul, South Korea. RP Kim, HC (reprint author), 5th Med Detachment, Seoul, South Korea. FU Armed Forces Health Surveillance Center-Global Emerging Infections Surveillance and Response System (AFHSC-GEIS), Silver Spring, MD; Foreign Animal Disease Division, Animal and Plant Quarantine Agency, Anyang, Gyeonggi Province, ROK; Korea National Institute of Health; Korea Centers for Disease Control and Prevention, Osong, Chungcheongbuk Province, ROK; Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand FX We thank COL Hee-Choon S. Lee, Chief, Force Health Protection and Preventive Medicine, 65th Medical Brigade, for his support. Special thanks to Mr. Dong-Chan Kim (Daeseongdong village mayor), the ROK Army Commander, and ROK Army soldiers at JSA (provide security for Daeseongdong), for their assistance in mosquito collections. This work was funded by the Armed Forces Health Surveillance Center-Global Emerging Infections Surveillance and Response System (AFHSC-GEIS), Silver Spring, MD, the Foreign Animal Disease Division, Animal and Plant Quarantine Agency, Anyang, Gyeonggi Province, ROK, the Korea National Institute of Health, the Korea Centers for Disease Control and Prevention, Osong, Chungcheongbuk Province, ROK, and the Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand. NR 56 TC 2 Z9 2 U1 0 U2 3 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD FEB PY 2015 VL 180 IS 2 BP 158 EP 167 DI 10.7205/MILMED-D-14-00206 PG 10 WC Medicine, General & Internal SC General & Internal Medicine GA CA7MR UT WOS:000349101900008 PM 25643383 ER PT J AU Walsh, DV Capo-Aponte, JE Jorgensen-Wagers, K Temme, LA Goodrich, G Sosa, J Riggs, DW AF Walsh, David V. Capo-Aponte, Jose E. Jorgensen-Wagers, Kendra Temme, Leonard A. Goodrich, Gregory Sosa, Josue Riggs, Daniel W. TI Visual Field Dysfunctions in Warfighters During Different Stages Following Blast and Nonblast mTBI SO MILITARY MEDICINE LA English DT Article ID TRAUMATIC BRAIN-INJURY; DOUBLING TECHNOLOGY PERIMETRY; NEUROOPHTHALMOLOGICAL FINDINGS; HEAD TRAUMA; FREQUENCY; REHABILITATION; POPULATION; IMPAIRMENT; EYE AB Objectives: Traumatic brain injury (TBI) is the leading injury coming out of the past decades' two major military conflicts, with mild TBI (mTBI) being the most commonly diagnosed form. The aim of this study was to assess the frequency and types of visual field (VF) defects seen at different testing stages following nonblast and blast-induced mTBI. Methods: A comprehensive retrospective review was performed on 500 electronic health records for military personnel sustaining an mTBI during deployment, of which 166 patients were tested with both confrontation VF and 30-2 Humphrey Matrix Frequency Doubling Technology (FDT) perimetry. Results: Scatter defects (48%) were the most predominantly found deficits in both blast and nonblast mTBI injury mechanisms and over postinjury test time frames. Confrontation VF was shown to be a poor qualitative predictor of VF defect. A profound decrease in VF sensitivity was noted in comparison to previously reported FDT normative data. Finally, a significant trend of decreasing VF defects was seen over time, indicating the potential usage of FDT as a visual biomarker for monitoring mTBI recovery. Conclusions: The findings of this study highlight the importance of performing threshold perimeter testing in those who have suffered an mTBI or concussion-like event. C1 [Walsh, David V.; Capo-Aponte, Jose E.; Temme, Leonard A.; Sosa, Josue; Riggs, Daniel W.] US Army Aeromed Res Lab, Sensory Res Div, Visual Sci Branch, Ft Rucker, AL 36362 USA. [Capo-Aponte, Jose E.] Womack Army Med Ctr, Dept Optometry, Ft Bragg, NC 28310 USA. [Jorgensen-Wagers, Kendra] Landstuhl Reg Med Ctr, Traumat Brain Injury Clin, D-09180 Landstuhl, Germany. [Goodrich, Gregory] Vet Affairs Palo Alto Hlth Care Syst, Psychol Serv & Western Blind Rehabil Ctr, Menlo Pk, CA 94025 USA. RP Walsh, DV (reprint author), US Army Aeromed Res Lab, Sensory Res Div, Visual Sci Branch, 6901 Farrel Rd, Ft Rucker, AL 36362 USA. FU Military Operational Medicine Research Program of the U.S. Army Medical Research and Materiel Command FX This research was funded by the Military Operational Medicine Research Program of the U.S. Army Medical Research and Materiel Command. NR 44 TC 2 Z9 2 U1 4 U2 5 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD FEB PY 2015 VL 180 IS 2 BP 178 EP 185 DI 10.7205/MILMED-D-14-00230 PG 8 WC Medicine, General & Internal SC General & Internal Medicine GA CA7MR UT WOS:000349101900010 PM 25643385 ER PT J AU Eckard, T Lopez, J Kaus, A Aden, J AF Eckard, Timothy Lopez, Joseph Kaus, Anna Aden, James TI Home Exercise Program Compliance of Service Members in the Deployed Environment: An Observational Cohort Study SO MILITARY MEDICINE LA English DT Article ID LOW-BACK-PAIN; REHABILITATION; ADHERENCE; ADULTS AB Background: Home exercise programs (HEP) are an integral part of any physical therapy treatment plan, but are especially important in theater. The primary aim of this study was to determine if the number of exercises prescribed in a HEP was associated with compliance rate of Service Members (SM) in theater with a secondary aim of determining variables associated with compliance and noncompliance. Materials/Methods: Subjects were 155 deployed SM undergoing physical therapy in Iraq and Afghanistan. Clinical evaluation and prescription of a HEP were performed. Pathologic, demographic, and treatment data were obtained. Subjects returned to the clinic 1 week later to demonstrate their HEP. Subjects' performance of each prescribed exercise was rated on a 12-point scale to quantify compliance. Results: 2 variables were found to be significantly associated with rate of compliance. These were the number of exercises prescribed (p = 0.02) and if a subject left the base at least once per week (p = 0.01). Conclusions: SM prescribed 4 or more exercises had a lower rate of compliance than those prescribed 2 or fewer. SM who left the base at least once per week also had a lower rate of compliance. C1 [Eckard, Timothy] US Army Hlth Ctr, Phys Therapy Dept, Vicenza, Italy. [Lopez, Joseph] Blanchfield Army Community Hosp, Phys Therapy Dept, Ft Campbell, KY 42223 USA. [Kaus, Anna] Brooke Army Med Ctr, Phys Therapy Dept, Ft Sam Houston, TX 78234 USA. [Aden, James] US Army, Inst Surg Res, Dept Stat & Epidemiol, Ft Sam Houston, TX 78234 USA. RP Eckard, T (reprint author), US Army Hlth Ctr, Phys Therapy Dept, Vicenza, Italy. NR 15 TC 2 Z9 2 U1 0 U2 9 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD FEB PY 2015 VL 180 IS 2 BP 186 EP 191 DI 10.7205/MILMED-D-14-00306 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA CA7MR UT WOS:000349101900011 PM 25643386 ER PT J AU Oh, RC Arter, JL Tiglao, SM Larson, SL AF Oh, Robert C. Arter, Joel L. Tiglao, Samuel M. Larson, Shane L. TI Exertional Rhabdomyolysis: A Case Series of 30 Hospitalized Patients SO MILITARY MEDICINE LA English DT Article ID SERUM CREATINE-KINASE AB Introduction: Exertional rhabdomyolysis is a clinical entity of significant muscle breakdown in the setting of exercise. However, clinical course and discharge criteria, once hospitalized, are poorly described. We describe 30 cases of exertional rhabdomyolysis and their hospital course. Methods: Thirty hospitalized cases with ICD-9 code of 722.88 (rhabdomyolysis) as the primary diagnosis were reviewed from 2010 to 2012. We excluded those with associated trauma, toxin, and heat illnesses. Results: The average length of stay was 3.6 days (range: 1-8 days). Length of stay correlated significantly with peak creatine kinase (CK) levels. The mean admission CK was 61,391 U/L (range 697-233,180 U/L). The mean discharge CK was 23,865 U/L with a wide range (1,410-94,665 U/L). Six cases (20%) had evidence of acute kidney injury, but most had serum creatinine (Cr) < 1.7 mg/dL. One had a peak Cr of 4.8 mg/dL. Higher serum Cr levels correlated significantly with lower CK levels. Twenty-nine out of 30 patients were discharged when CKs downtrended. Conclusion: Higher peak CK levels predicted longer length of stay. Higher serum Cr significantly correlated with lower CK levels. There did not appear to be any threshold CK for admission or discharge, however, all but one patient were discharged after CK downtrended. C1 [Oh, Robert C.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [Arter, Joel L.] US Army Hlth Clin Schofield Barracks, Schofield Barracks, HI 96786 USA. [Tiglao, Samuel M.] Tripler Army Med Ctr, Dept Family Med, Honolulu, HI 96859 USA. RP Oh, RC (reprint author), Uniformed Serv Univ Hlth Sci, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA. NR 15 TC 5 Z9 5 U1 0 U2 0 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD FEB PY 2015 VL 180 IS 2 BP 201 EP 207 DI 10.7205/MILMED-D-14-00274 PG 7 WC Medicine, General & Internal SC General & Internal Medicine GA CA7MR UT WOS:000349101900013 PM 25643388 ER PT J AU Wojcik, BE Curley, KC Szeszel-Fedorowicz, W Stein, CR Humphrey, RJ AF Wojcik, Barbara E. Curley, Kenneth C. Szeszel-Fedorowicz, Wioletta Stein, Catherine R. Humphrey, Rebecca J. TI Spinal Injury Hospitalizations Among US Army Soldiers Deployed to Iraq and Afghanistan SO MILITARY MEDICINE LA English DT Article ID TRAUMATIC BRAIN-INJURY; IMPROVISED EXPLOSIVE DEVICE; COMBAT CASUALTY CARE; MILITARY PERSONNEL; CORD INJURIES; FREEDOM; WARTIME; WOUNDS; DEATH; BLAST AB This retrospective study examined spinal-related hospitalizations of U.S. Army soldiers deployed to Afghanistan and Iraq. Spinal cord injuries (SCI) and vertebral column injuries (VCI) were identified using International Classification of Disease, 9th Revision, Clinical Modification diagnosis codes. In our study, spinal hospitalizations represented 8.2% of total injury admissions. Risk factors for SCI and VCI incidences were determined using Poisson regression. Lack of previous deployment experience increased risk of having SCI by 33% and VCI by 24% in Iraq (similar increases, but not statistically significant in Afghanistan). Male soldiers had 4.85 times higher risk for SCI in Iraq and 69% higher risk in Afghanistan than female soldiers. In Afghanistan, almost 60% of spinal episodes included traumatic brain injury (TBI), compared to about 40% in Iraq. In both theaters, mild TBI accounted for more than 50% of all TBI-spinal episodes. Sixteen percent of SCI inpatient episodes in Afghanistan and 13% in Iraq were associated with paralysis, with median bed days of 46 and 33 days compared to a median of 6 days in both theaters for nonparalysis spinal injuries. The mortality rate was 2.5 times lower in Afghanistan than in Iraq. C1 [Wojcik, Barbara E.; Szeszel-Fedorowicz, Wioletta; Stein, Catherine R.; Humphrey, Rebecca J.] Ctr US Army Med Dept Strateg Studies, Ft Sam Houston, TX 78234 USA. [Curley, Kenneth C.] US Army Med Res & Mat Command, Combat Casualty Care Directorate RAD2, Ft Detrick, MD 21702 USA. RP Wojcik, BE (reprint author), Ctr US Army Med Dept Strateg Studies, 2478 Stanley Rd Suite 47, Ft Sam Houston, TX 78234 USA. NR 36 TC 1 Z9 1 U1 0 U2 1 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD FEB PY 2015 VL 180 IS 2 BP 216 EP 223 DI 10.7205/MILMED-D-14-000061 PG 8 WC Medicine, General & Internal SC General & Internal Medicine GA CA7MR UT WOS:000349101900015 PM 25643390 ER PT J AU Cutter, L AF Cutter, Laura TI The Unusual Case of Private George Lemon SO MILITARY MEDICINE LA English DT Editorial Material C1 US Army Med Res & Mat Command, Amer Registry Pathol, Natl Museum Hlth & Med, Silver Spring, MD 20910 USA. RP Cutter, L (reprint author), US Army Med Res & Mat Command, Amer Registry Pathol, Natl Museum Hlth & Med, 2500 Linden Lane, Silver Spring, MD 20910 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD FEB PY 2015 VL 180 IS 2 BP 241 EP 242 DI 10.7205/MILMED-D-14-00522 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA CA7MR UT WOS:000349101900019 PM 25643394 ER PT J AU Liu, JM Pattanaik, S Yao, JH Dwyer, AJ Pickhardt, PJ Choi, JR Summers, RM AF Liu, Jiamin Pattanaik, Sanket Yao, Jianhua Dwyer, Andrew J. Pickhardt, Perry J. Choi, J. Richard Summers, Ronald M. TI Associations Among Pericolonic Fat, Visceral Fat, and Colorectal Polyps on CT Colonography SO OBESITY LA English DT Article DE colonic polyps; CT; colon; CT; virtual imaging; pericolonic fat measurement; visceral fat measurement ID ADIPOSE-TISSUE; CANCER; COLONOSCOPY; OBESITY; COLON; RISK AB ObjectiveTo determine the association between pericolonic fat and colorectal polyps using CT colonography (CTC). MethodsA total of 1169 patients who underwent CTC and optical colonoscopy on the same day were assessed. Pericolonic fat was measured on CTC in a band surrounding the colon. Visceral adipose tissue volume was measured at the L2-L3 levels. Student's t-tests, odds ratio, logistic regression, binomial statistics, and weighted kappa were performed to ascertain associations with the incidence of colorectal polyps. ResultsPericolonic fat volume fractions (PFVF) were 61.511.0% versus 58.1 +/- 11.5%, 61.6 +/- 11.1% versus 58.7 +/- 11.5%, and 62.4 +/- 10.6% versus 58.8 +/- 11.5% for patients with and without any polyps, adenomatous polyps, and hyperplastic polyps, respectively (P<0.0001). Similar trends were observed when examining visceral fat volume fractions (VFVF). When patients were ordered by quintiles of PFVF or VFVF, there were 2.49-, 2.19-, and 2.39-fold increases in odds ratio for the presence of any polyp, adenomatous polyps, or hyperplastic polyps from the first to the fifth quintile for PFVF and 1.92-, 2.00-, and 1.71-fold increases in odds ratio for VFVF. Polyps tended to occur more commonly in parts of the colon that had more PFVF than the spatially adjusted average for patients in the highest quintile of VFVF. ConclusionsPericolonic fat accumulations, like visceral fat, are correlated with an increased risk of adenomatous and hyperplastic polyps. C1 [Liu, Jiamin; Pattanaik, Sanket; Yao, Jianhua; Dwyer, Andrew J.; Summers, Ronald M.] NIH, Imaging Biomarkers & Comp Aided Diag Lab, Ctr Clin, Bethesda, MD 20892 USA. [Pickhardt, Perry J.] Univ Wisconsin, Dept Radiol, Sch Med, Clin Sci Ctr E3 311, Madison, WI 53706 USA. [Choi, J. Richard] Walter Reed Army Med Ctr, Washington, DC 20307 USA. RP Summers, RM (reprint author), NIH, Imaging Biomarkers & Comp Aided Diag Lab, Ctr Clin, Bldg 10, Bethesda, MD 20892 USA. EM rms@nih.gov FU Intramural Research Program of the National Institutes of Health, Clinical Center FX Intramural Research Program of the National Institutes of Health, Clinical Center. NR 25 TC 2 Z9 2 U1 1 U2 2 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1930-7381 EI 1930-739X J9 OBESITY JI Obesity PD FEB PY 2015 VL 23 IS 2 BP 408 EP 414 DI 10.1002/oby.20987 PG 7 WC Endocrinology & Metabolism; Nutrition & Dietetics SC Endocrinology & Metabolism; Nutrition & Dietetics GA CA6QN UT WOS:000349040400024 PM 25558027 ER PT J AU Tamburello, RN Herrmann, JW AF Tamburello, Robert N. Herrmann, Jeffrey W. TI A simulation-based approach to determine the evaluation adequacy of system-of-systems operational test configurations SO PROCEEDINGS OF THE INSTITUTION OF MECHANICAL ENGINEERS PART O-JOURNAL OF RISK AND RELIABILITY LA English DT Article DE System-of-systems; reliability; operational test; test configuration; stochastic simulation; Monte Carlo; evaluation adequacy; test and evaluation; reliability test program planning AB A system-of-systems is defined as a set or arrangement of systems that results from independent systems integrated into a larger system that delivers unique capabilities. Given practical resource constraints, it is rare that the full-field configuration of the system-of-systems can be exercised during an operational reliability demonstration test. However, as we consider various potential operational test configurations for a given system-of-systems during the reliability test program planning process, it is critical to understand how testing a configuration that is smaller than the full-field configuration decreases the adequacy of the test by reducing the accuracy of the system-of-systems' reliability estimate that is based on the test results. Thus, it is useful to assess the adequacy of potential system-of-systems' operational test configurations before adopting one. We present a novel simulation-based method that can be employed to assess the adequacy of a given test configuration for any type of system-of-systems. To illustrate how this simulation-based method can be used to aid in the identification of the best alternative from among a group of potential operational test configuration alternatives, we include an example application using a notional air defense system-of-systems. Trade-offs with respect to cost, schedule, and accuracy are addressed within the context of this application. C1 [Tamburello, Robert N.] US Army, Evaluat Ctr, Aberdeen Proving Ground, MD 21005 USA. [Herrmann, Jeffrey W.] Univ Maryland, Dept Mech Engn, Syst Res Inst, College Pk, MD 20742 USA. RP Tamburello, RN (reprint author), US Army, Evaluat Ctr, 2202 Aberdeen Blvd,ATTN 2nd Floor ISMED, Aberdeen Proving Ground, MD 21005 USA. EM robert.n.tamburello.civ@mail.mil NR 10 TC 0 Z9 0 U1 0 U2 3 PU SAGE PUBLICATIONS LTD PI LONDON PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND SN 1748-006X EI 1748-0078 J9 P I MECH ENG O-J RIS JI Proc. Inst. Mech. Eng. Part O-J. Risk Reliab. PD FEB PY 2015 VL 229 IS 1 BP 46 EP 51 DI 10.1177/1748006X14549394 PG 6 WC Engineering, Multidisciplinary; Engineering, Industrial; Operations Research & Management Science SC Engineering; Operations Research & Management Science GA CA9DU UT WOS:000349221400005 ER PT J AU Cooper, CL Bavari, S AF Cooper, Christopher L. Bavari, Sina TI A race for an Ebola vaccine: promises and obstacles SO TRENDS IN MICROBIOLOGY LA English DT Editorial Material DE Ebola; vaccine; FDA clinical trial; immune correlates; durable immunity ID VIRUS; IMMUNITY AB While several impeding factors have limited Ebola vaccine development, the current epidemic has provided a surge which may lead to a record pace for a vaccine against Ebola. Consequently, multiple FDA trials are currently underway using two promising vaccine platforms; one has recently demonstrated durable immunity within non-human primates. C1 [Cooper, Christopher L.; Bavari, Sina] US Army, Med Res Inst Infect Dis, Mol & Translat Sci, Ft Detrick, MD 21702 USA. RP Bavari, S (reprint author), US Army, Med Res Inst Infect Dis, Mol & Translat Sci, Ft Detrick, MD 21702 USA. EM sina.bavari.civ@mail.mil NR 10 TC 10 Z9 10 U1 0 U2 21 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0966-842X EI 1878-4380 J9 TRENDS MICROBIOL JI Trends Microbiol. PD FEB PY 2015 VL 23 IS 2 BP 65 EP 66 DI 10.1016/j.tim.2014.12.005 PG 2 WC Biochemistry & Molecular Biology; Microbiology SC Biochemistry & Molecular Biology; Microbiology GA CB3AS UT WOS:000349500700001 PM 25535021 ER PT J AU Fuller, ME Hatzinger, PB Condee, CW Andaya, C Vainberg, S Michalsen, MM Crocker, FH Indest, KJ Jung, CM Eaton, H Istok, JD AF Fuller, Mark E. Hatzinger, Paul B. Condee, Charles W. Andaya, Christina Vainberg, Simon Michalsen, Mandy M. Crocker, Fiona H. Indest, Karl J. Jung, Carina M. Eaton, Hillary Istok, Jonathan D. TI Laboratory evaluation of bioaugmentation for aerobic treatment of RDX in groundwater SO BIODEGRADATION LA English DT Article DE RDX; Bioaugmentation; Bacterial transport; Degradation ID SP STRAIN DN22; HEXAHYDRO-1,3,5-TRINITRO-1,3,5-TRIAZINE RDX; EXPLOSIVE HEXAHYDRO-1,3,5-TRINITRO-1,3,5-TRIAZINE; BACTERIAL TRANSPORT; INTACT CORES; RHODOCOCCUS; DEGRADATION; GORDONIA; BIODEGRADATION; MINERALIZATION AB The potential for bioaugmentation with aerobic explosive degrading bacteria to remediate hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) contaminated aquifers was demonstrated. Repacked aquifer sediment columns were used to examine the transport and RDX degradation capacity of the known RDX degrading bacterial strains Gordonia sp. KTR9 (modified with a kanamycin resistance gene) Pseudomonas fluorescens I-C, and a kanamycin resistant transconjugate Rhodococcus jostii RHA1 pGKT2:Km(+). All three strains were transported through the columns and eluted ahead of the conservative bromide tracer, although the total breakthrough varied by strain. The introduced cells responded to biostimulation with fructose (18 mg L-1, 0.1 mM) by degrading dissolved RDX (0.5 mg L-1, 2.3 A mu M). The strains retained RDX-degrading activity for at least 6 months following periods of starvation when no fructose was supplied to the column. Post-experiment analysis of the soil indicated that the residual cells were distributed along the length of the column. When the strains were grown to densities relevant for field-scale application, the cells remained viable and able to degrade RDX for at least 3 months when stored at 4 A degrees C. These results indicate that bioaugmentation may be a viable option for treating RDX in large dilute aerobic plumes. C1 [Fuller, Mark E.; Hatzinger, Paul B.; Condee, Charles W.; Andaya, Christina; Vainberg, Simon] CB&I Fed Serv, Lawrenceville, NJ 08648 USA. [Michalsen, Mandy M.] US Army Corps Engineers, Engn Design Branch, Seattle, WA 98134 USA. [Crocker, Fiona H.; Indest, Karl J.; Jung, Carina M.] US Army Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA. [Eaton, Hillary] Embry Riddle Aeronaut Univ, Dept Phys, Prescott, AZ 86301 USA. [Istok, Jonathan D.] Oregon State Univ, Sch Civil & Construct Engn, Corvallis, OR 97331 USA. RP Fuller, ME (reprint author), CB&I Fed Serv, 17 Princess Rd, Lawrenceville, NJ 08648 USA. EM mark.fuller@cbifederalservices.com FU Environmental Security Technology Certification Program (ESTCP) [W912DW-12-C-0029] FX This project was supported by the Environmental Security Technology Certification Program (ESTCP) under contract W912DW-12-C-0029. Views, opinions, and/or findings contained in this report are those of the author(s) and should not be construed as an official Department of Defense position or decision unless so designated by other official documentation. NR 40 TC 3 Z9 3 U1 1 U2 23 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0923-9820 EI 1572-9729 J9 BIODEGRADATION JI Biodegradation PD FEB PY 2015 VL 26 IS 1 BP 77 EP 89 DI 10.1007/s10532-014-9717-y PG 13 WC Biotechnology & Applied Microbiology SC Biotechnology & Applied Microbiology GA AZ8DL UT WOS:000348444900007 PM 25503243 ER PT J AU Lesho, EP Clifford, RJ Chukwuma, U Kwak, YI Maneval, M Neumann, C Xie, S Nielsen, LE Julius, MD McGann, P Waterman, PE AF Lesho, Emil P. Clifford, Robert J. Chukwuma, Uzo Kwak, Yoon I. Maneval, Mark Neumann, Charlotte Xie, Suji Nielsen, Lindsey E. Julius, Michael D. McGann, Patrick Waterman, Paige E. TI Carbapenem-resistant Enterobacteriaceae and the correlation between carbapenem and fluoroquinolone usage and resistance in the US military health system SO DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE LA English DT Article DE Antibiotic use; Antibiotic consumption; Healthcare network; Carbapenem resistance ID KLEBSIELLA-PNEUMONIAE; UNITED-STATES; ANTIBIOTIC USAGE; CARE FACILITIES; K.-PNEUMONIAE; GLOBAL SPREAD; RISK-FACTORS; INFECTIONS; SURVEILLANCE; BLOOD AB Whether carbapenem or fluoroquinolone usage is correlated with carbapenem-resistant Enterobacteriaceae (CRE) has not been investigated at the level of an entire US nationwide managed health care system. We analyzed 75 million person-years of surveillance and 1,969,315 cultures from all 266 hospitals in the geographically dispersed US military health system. Incidences of CRE remained under 1 case per 100,000 person-years. Incidences of CRE increased relative to 2005 baseline levels in 3 of 7 subsequent years, then decreased in 2012 (P < 0.05). Incident proportions of carbapenem resistance (CR) differed significantly among years, geographical regions, and bacterial species. Although use and resistance strongly correlated (R > 0.80) for several "drug-bug" combinations, none were significant at the national or facility level. One exception was that inpatient consumption of fluoroquinolones was significantly correlated (P = 0.0007) with CR in Escherichia coli when data from the major referral centers of the Southern and Northern regions were combined. Published by Elsevier Inc. C1 [Lesho, Emil P.; Clifford, Robert J.; Kwak, Yoon I.; Nielsen, Lindsey E.; Julius, Michael D.; McGann, Patrick; Waterman, Paige E.] Walter Reed Army Inst Res, Multidrugresistant Organism Repositoty & Surveill, Silver Spring, MD 20910 USA. [Chukwuma, Uzo; Neumann, Charlotte] Navy & Marine Corps Public Hlth Ctr, EpiData Ctr Dept, Portsmouth, VA USA. [Maneval, Mark; Xie, Suji] US Army, Pharmacovigilance Ctr, Falls Church, VA USA. RP Lesho, EP (reprint author), Walter Reed Army Inst Res, Multidrugresistant Organism Repositoty & Surveill, Silver Spring, MD 20910 USA. EM carolinelesho@yahoo.com FU US Army Medical Command; Armed Forces Health Surveillance Center-Global Emerging Infections Surveillance and Response System FX This work was supported by the US Army Medical Command and the Armed Forces Health Surveillance Center-Global Emerging Infections Surveillance and Response System, who had no role in the collection or analysis of data, nor the preparation of the manuscript. NR 39 TC 1 Z9 1 U1 0 U2 5 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0732-8893 EI 1879-0070 J9 DIAGN MICR INFEC DIS JI Diagn. Microbiol. Infect. Dis. PD FEB PY 2015 VL 81 IS 2 BP 119 EP 125 DI 10.1016/j.diagmicrobio.2014.09.017 PG 7 WC Infectious Diseases; Microbiology SC Infectious Diseases; Microbiology GA AZ8WD UT WOS:000348491500010 PM 25497458 ER PT J AU Anders, MA Lenahan, PM Cochrane, CJ Lelis, AJ AF Anders, Mark A. Lenahan, Patrick M. Cochrane, Corey J. Lelis, Aivars J. TI Relationship Between the 4H-SiC/SiO2 Interface Structure and Electronic Properties Explored by Electrically Detected Magnetic Resonance SO IEEE TRANSACTIONS ON ELECTRON DEVICES LA English DT Article DE 4H-silicon carbide (4H-SiC) MOSFET; defects; interface; magnetic resonance ID CHARGE-PUMPING MEASUREMENTS; CHANNEL MOBILITY; NITRIC-OXIDE; MOSFETS; NITRIDATION; SILICON AB In this paper, an exceptionally sensitive form of electron paramagnetic resonance called electrically detected magnetic resonance (EDMR) is utilized to investigate performance limiting imperfections at and very near the interface of 4H-silicon carbide MOSFETs. EDMR measurements are made over an extremely wide range of frequencies, 16 GHz-350 MHz. Multiple interface/near interface defects are identified and strong evidence for significant disorder at the interface region is presented. C1 [Anders, Mark A.; Lenahan, Patrick M.] Penn State Univ, Dept Engn Sci & Mech, University Pk, PA 16801 USA. [Cochrane, Corey J.] Penn State Univ, University Pk, PA 16801 USA. [Lelis, Aivars J.] US Army Res Lab, Adelphi, MD 20783 USA. RP Anders, MA (reprint author), Penn State Univ, Dept Engn Sci & Mech, University Pk, PA 16801 USA. EM maa5297@psu.edu; pmlesm@engr.psu.edu; corey.j.cochrane@jpl.nasa.gov; aivars.j.lelis.civ@mail.mil FU U.S. Army Research Laboratory, Adelphi, MD, USA; U.S. Department of Defense, Washington, DC, USA FX This work was supported in part by the U.S. Army Research Laboratory, Adelphi, MD, USA, and in part by the U.S. Department of Defense, Washington, DC, USA. The review of this paper was arranged by Editor N. Ohtani. NR 31 TC 4 Z9 4 U1 2 U2 35 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0018-9383 EI 1557-9646 J9 IEEE T ELECTRON DEV JI IEEE Trans. Electron Devices PD FEB PY 2015 VL 62 IS 2 BP 301 EP 308 DI 10.1109/TED.2014.2364722 PG 8 WC Engineering, Electrical & Electronic; Physics, Applied SC Engineering; Physics GA AZ7FZ UT WOS:000348386100008 ER PT J AU Lelis, AJ Green, R Habersat, DB El, M AF Lelis, Aivars J. Green, Ron Habersat, Daniel B. El, Mooro TI Basic Mechanisms of Threshold-Voltage Instability and Implications for Reliability Testing of SiC MOSFETs SO IEEE TRANSACTIONS ON ELECTRON DEVICES LA English DT Article DE Oxide trap; power MOSFET; reliability; silicon carbide (SiC); threshold voltage ID HIGH-TEMPERATURE RELIABILITY; CHARGE-PUMPING MEASUREMENTS; POWER MOSFETS; MOS DEVICES; STRESS; DEPENDENCE; DMOSFET; TRAPS; STABILITY; ISSUES AB A review of the basic mechanisms affecting the stability of the threshold voltage in response to a bias-temperature stress is presented in terms of the charging and activation of near-interfacial oxide traps. An activation energy of approximately 1.1 eV was calculated based on new experimental results. Implications of these factors, including the recovery of some bias-temperature stress-activated defects, for improved device reliability testing are discussed. C1 [Lelis, Aivars J.; Green, Ron; Habersat, Daniel B.; El, Mooro] US Army Res Lab, Adelphi, MD 20783 USA. RP Lelis, AJ (reprint author), US Army Res Lab, Adelphi, MD 20783 USA. EM aivars.j.lelis.civ@mail.mil; ronald.green39.civ@mail.mil; daniel.b.habersat.civ@mail.mil; mooro.i.el.civ@mail.mil NR 51 TC 23 Z9 23 U1 12 U2 64 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0018-9383 EI 1557-9646 J9 IEEE T ELECTRON DEV JI IEEE Trans. Electron Devices PD FEB PY 2015 VL 62 IS 2 BP 316 EP 323 DI 10.1109/TED.2014.2356172 PG 8 WC Engineering, Electrical & Electronic; Physics, Applied SC Engineering; Physics GA AZ7FZ UT WOS:000348386100010 ER PT J AU Indest, KJ Eberly, JO Ringelberg, DB Hancock, DE AF Indest, Karl J. Eberly, Jed O. Ringelberg, David B. Hancock, Dawn E. TI The effects of putative lipase and wax ester synthase/acyl-CoA:diacylglycerol acyltransferase gene knockouts on triacylglycerol accumulation in Gordonia sp KTR9 SO JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY LA English DT Article DE Triacyglycerol; Lipase; WS/DGAT; Gordonia ID RHODOCOCCUS-OPACUS PD630; SP STRAIN ADP1; CHLAMYDOMONAS-REINHARDTII; DIACYLGLYCEROL ACYLTRANSFERASE; MYCOBACTERIUM-TUBERCULOSIS; ESCHERICHIA-COLI; COENZYME-A; IDENTIFICATION; BIOSYNTHESIS; METABOLISM AB Previously, we demonstrated triacylglycerol (TAG) accumulation and the in vivo ability to catalyze esters from exogenous short chain alcohol sources in Gordonia sp. strain KTR9. In this study, we investigated the effects that putative lipase (KTR9_0186) and wax ester synthase/acyl-CoA:diacylglycerol acyltransferase (WS/DGAT; KTR9_3844) gene knockouts had on TAG accumulation. Gene disruption of KTR9_0186 resulted in a twofold increase in TAG content in nitrogen starved cells. Lipase mutants subjected to carbon starvation, following nitrogen starvation, retained 75 % more TAGs and retained pigmentation. Transcriptome expression data confirmed the deletion of KTR9_0186 and identified the up-regulation of key genes involved in fatty acid degradation, a likely compensatory mechanism for reduced TAG mobilization. In vitro assays with purified KTR9_3844 demonstrated WS/DGAT activity with short chain alcohols and C16 and C18 fatty acid Co-As. Collectively, these results indicate that Gordonia sp. KTR9 has a suitable tractable genetic background for TAG production as well as the enzymatic capacity to catalyze fatty acid esters from short chain alcohols. C1 [Indest, Karl J.; Eberly, Jed O.; Hancock, Dawn E.] US Army Engineer Res & Dev Ctr, Environm Lab, CEERD EP P, Vicksburg, MS 39180 USA. [Ringelberg, David B.] US Army Engineer Res & Dev Ctr, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. RP Indest, KJ (reprint author), US Army Engineer Res & Dev Ctr, Environm Lab, CEERD EP P, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM indestk@wes.army.mil FU US Army Engineer Research and Development Center's Basic Research Program [10-50] FX This research was funded through the US Army Engineer Research and Development Center's Basic Research Program (Project 10-50, K. J. Indest). Views, opinions and/or findings contained herein are those of the authors and should not be construed as an official Department of the Army position or decision unless so designated by other official documentation. NR 30 TC 1 Z9 1 U1 4 U2 19 PU SPRINGER HEIDELBERG PI HEIDELBERG PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY SN 1367-5435 EI 1476-5535 J9 J IND MICROBIOL BIOT JI J. Ind. Microbiol. Biotechnol. PD FEB PY 2015 VL 42 IS 2 BP 219 EP 227 DI 10.1007/s10295-014-1552-y PG 9 WC Biotechnology & Applied Microbiology SC Biotechnology & Applied Microbiology GA AZ7RT UT WOS:000348416300007 PM 25487758 ER PT J AU Perry, J Stankorb, SM Salgueiro, M AF Perry, Jeffery Stankorb, Susan M. Salgueiro, Marybeth TI Microbial Contamination of Enteral Feeding Products in Thermoneutral and Hyperthermal ICU Environments SO NUTRITION IN CLINICAL PRACTICE LA English DT Article DE nutritional support; food safety; food contamination; intensive care units; burns; enteral formulas; enteral nutrition ID BACTERIAL-CONTAMINATION; BURN PATIENTS; AMBIENT-TEMPERATURE; NUTRITION; EPIDEMIOLOGY; INJURY; CARE AB Background: Temperature is known to affect bacterial growth, but current safety recommendations for enteral formula are based on studies conducted in thermoneutral environments, which are not representative of select burn intensive care units (ICUs) that are kept therapeutically hyperthermal. This project evaluated microbial growth in 3 enteral feeding systems: closed, open, and open with modular additives (modular tube feeding [MTF]) exposed to 2 different environments. Procedures: Product for each of the 3 systems was prepared and hung in both a thermoneutral (23.3 degrees C) and a hyperthermal (32.5 degrees C) ICU room. At baseline, 4 hours, and 8 hours, samples were plated and incubated overnight and the number of colony-forming units (CFUs) counted. Findings: In the thermoneutral and hyperthermal environments, there was no evidence of microbial growth in the open or closed feeding systems at any time point. The MTF exhibited baseline contamination with a median of 10 CFUs (95% CI, 8-16) and significant growth over time to 54 CFUs (95% CI, 20-230) by 8 hours in the thermoneutral setting. In the hyperthermal environment, the MTF showed baseline contamination of 390 CFUs (95% CI, 40-1600) and significant growth over time, with 30% of samples exhibiting contamination levels exceeding Food and Drug Administration standards by 4 hours and CFUs being too numerous to count by 8 hours. Conclusion: CFUs in enteral formula did not differ between open and closed feeding systems in either environment for up to 8 hours; however, the addition of modulars to open systems may result in an unacceptable risk of contamination in hyperthermal environments. C1 [Perry, Jeffery; Stankorb, Susan M.; Salgueiro, Marybeth] Mil Baylor Grad Program Nutr, Jbsa Ft Sam Houston, TX USA. [Perry, Jeffery; Stankorb, Susan M.; Salgueiro, Marybeth] Brooke Army Med Ctr, San Antonio, TX 78217 USA. RP Stankorb, SM (reprint author), Brooke Army Med Ctr, 4254 Hilton Head St, San Antonio, TX 78217 USA. EM susan.stankorb.mil@mail.mil FU Department of Clinical Investigations, Brooke Army Medical Center FX This project was funded by the Department of Clinical Investigations, Brooke Army Medical Center. NR 27 TC 1 Z9 1 U1 1 U2 4 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0884-5336 EI 1941-2452 J9 NUTR CLIN PRACT JI Nutr. Clin. Pract. PD FEB PY 2015 VL 30 IS 1 BP 128 EP 133 DI 10.1177/0884533614541680 PG 6 WC Nutrition & Dietetics SC Nutrition & Dietetics GA AZ7CO UT WOS:000348376200015 PM 25118176 ER PT J AU Scibora, LM Buchwald, H Petit, MA Hughes, J Ikramuddin, S AF Scibora, Lesley M. Buchwald, Henry Petit, Moira A. Hughes, Julie Ikramuddin, Sayeed TI Bone Strength Is Preserved Following Bariatric Surgery SO OBESITY SURGERY LA English DT Article DE Bariatric surgery; Morbid obesity; Bone; Bone mineral density; Bone strength; Peripheral quantitative computed tomography (pQCT) ID GASTRIC BYPASS-SURGERY; OBESE PREMENOPAUSAL WOMEN; X-RAY ABSORPTIOMETER; QUALITY-OF-LIFE; WEIGHT-LOSS; BODY-COMPOSITION; FAT MASS; PHYSICAL-ACTIVITY; MINERAL DENSITY; HIP FRACTURE AB There is an increasing concern that bariatric surgery results in excessive bone loss as demonstrated by studies that use areal bone mineral density (aBMD) outcomes by dual energy X-ray absorptiometry (DXA). Thus, we explored the effect of bariatric surgery on bone mechanical strength. Bone strength and body composition outcomes were measured in 21 adults (age 45.3 years; BMI 45.7 kg/m(2)) at baseline (pre-surgery) and 3, 6, and 12 months post-surgery. Bone geometry, density and strength were assessed by peripheral quantitative computed tomography (pQCT) at the distal (4 %) sites of the radius and tibia and at the midshaft sites of the tibia (66 %) and radius (50 %). Participants were divided into tertiles (high, medium, and low) of percentage weight loss at 6 months post-surgery. Participants in all three tertiles lost significant body weight by 6 months post-surgery (mean loss -5 to -30 %, all p < 0.05). At 6 months, all tertiles lost significant fat mass (-9 to -51 %, all p < 0.05), but only the high tertile lost significant fat-free mass (-8 %, p < 0.05). Despite a slight increase in tibia bone strength (SSIp) at 3 months (+1.1 %, p < 0.05), estimates of bone strength at the radius and tibia sites did not change at later post-surgical time points regardless of weight loss. Contrary to DXA-based aBMD outcomes in the current literature, these results suggest that bone strength was preserved up to 12 months following bariatric surgery. Future longer-term studies exploring bone strength and geometry are needed to confirm these findings. C1 [Scibora, Lesley M.] Univ Minnesota, Sch Kinesiol, Minneapolis, MN 55455 USA. [Buchwald, Henry; Ikramuddin, Sayeed] Univ Minnesota, Dept Surg, VCRC, Minneapolis, MN 55455 USA. [Petit, Moira A.] Activ8 LLC, St Paul, MN 55105 USA. [Hughes, Julie] US Army, Inst Environm Med, Mil Performance Div, Natick, MA 01760 USA. [Scibora, Lesley M.] Univ St Thomas, Hlth & Human Performance Dept, St Paul, MN 55105 USA. RP Scibora, LM (reprint author), Univ St Thomas, Hlth & Human Performance Dept, 2115 Summit Ave,Mail 4004, St Paul, MN 55105 USA. EM l.scibora@stthomas.edu; buchw001@umn.edu; moira@activ8-u.com; julie.m.hughes17.ctr@mail.mil; ikram003@umn.edu FU Minnesota Obesity Consortium FX This project was supported by a grant from the Minnesota Obesity Consortium. NR 40 TC 1 Z9 1 U1 0 U2 7 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0960-8923 EI 1708-0428 J9 OBES SURG JI Obes. Surg. PD FEB PY 2015 VL 25 IS 2 BP 263 EP 270 DI 10.1007/s11695-014-1341-8 PG 8 WC Surgery SC Surgery GA AZ3ER UT WOS:000348111000010 PM 24972685 ER PT J AU Jain, RB AF Jain, Ram B. TI Serum cotinine and urinary 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanonol levels among non-Hispanic Asian American smokers and nonsmokers as compared to other race/ethnicities: Data from NHANES 2011-2012 SO CHEMOSPHERE LA English DT Article DE Asian American; Race/ethnicity; Second hand smoke; Smoking biomarkers ID DAILY CIGARETTE SMOKERS; METABOLISM; NICOTINE AB The objective of this study was to evaluate serum cotinine and total urinary 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanonol (NNAL) levels from a nationally representative sample of non-Hispanic Asian Americans as compared with other racial/ethnic groups. Data from the latest National Health and Nutrition Examination Survey for the years 2011-2012 were used for this purpose. The total sample size used was 4580. Regression models were fitted to estimate serum cotinine and urinary NNAL levels for smokers and nonsmokers aged 20 years and older adjusted for other factors that affect these levels. For nonsmokers, exposure to second hand smoke at home was associated with about 30 times higher serum cotinine levels when compared to those without such exposure (0.717 ng mL(-1) vs. 0.024 ng mL(-1), p < 0.01). NNAL levels among nonsmokers with second hand smoke exposure at home were about twenty times what they were in those without such exposure (9 pg mL(-1) vs. 109 pg mL(-1), p < 0.01). As compared to other racial/ethnic groups, the lowest adjusted serum cotinine levels occurred in non-Hispanic Asian smokers (92.6 ng mL(-1)) and Hispanics (84.5 ng mL(-1)) as compared to non-Hispanic whites (143.8 ng mL(-1)) and non-Hispanic blacks (158.4 ng mL(-1)). Urinary NNAL levels for smokers were in the order: non-Hispanic Asian (0.121 ng mL(-1)) < non-Hispanic blacks (0.139 ng mL(-1)) < Hispanics (0.201 ng mL(-1)) < non-Hispanic whites (0.234 ng mL(-1)). Compared to non-Hispanic whites, non-Hispanic blacks had substantially higher levels of serum cotinine but substantially lower levels of urinary NNAL irrespective of smoking status thus pointing towards differences in elimination kinetics of nicotine/cotinine and NNAL. (C) 2014 Elsevier Ltd. All rights reserved. C1 [Jain, Ram B.] Womack Army Med Ctr, Ft Bragg, NC 28310 USA. [Jain, Ram B.] Empiristat Inc, Mt Airy, MD USA. RP Jain, RB (reprint author), Womack Army Med Ctr, Dept Clin Invest, Ft Bragg, NC 28310 USA. EM ram.b.jain.ctr@mail.mil NR 16 TC 4 Z9 4 U1 3 U2 6 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0045-6535 EI 1879-1298 J9 CHEMOSPHERE JI Chemosphere PD FEB PY 2015 VL 120 BP 584 EP 591 DI 10.1016/j.chemosphere.2014.09.069 PG 8 WC Environmental Sciences SC Environmental Sciences & Ecology GA AZ1MN UT WOS:000348003200081 PM 25462301 ER PT J AU Klungthong, C Manasatienkij, W Phonpakobsin, T Chinnawirotpisan, P Rodpradit, P Hussem, K Thaisomboonsuk, B Ong-ajchaowlerd, P Nisalak, A Kalayanarooj, S Buddhari, D Gibbons, RV Jarman, RG Yoon, IK Fernandez, S AF Klungthong, Chonticha Manasatienkij, Wudtichai Phonpakobsin, Thipwipha Chinnawirotpisan, Piyawan Rodpradit, Prinyada Hussem, Kittinun Thaisomboonsuk, Butsaya Ong-ajchaowlerd, Prapapun Nisalak, Ananda Kalayanarooj, Siripen Buddhari, Darunee Gibbons, Robert V. Jarman, Richard G. Yoon, In-Kyu Fernandez, Stefan TI Monitoring and improving the sensitivity of dengue nested RT-PCR used in longitudinal surveillance in Thailand SO JOURNAL OF CLINICAL VIROLOGY LA English DT Article DE Dengue virus; RT-PCR; Dengue surveillance ID REVERSE-TRANSCRIPTASE PCR; POLYMERASE-CHAIN-REACTION; VIRUS SEROTYPE 4; INFECTION; CIRCULATION; BANGKOK; SAMPLES; ASSAY AB Background: AFRIMS longitudinal dengue surveillance in Thailand depends on the nested RT-PCR and the dengue IgM/IgG ELISA. Objective: To examine and improve the sensitivity of the nested RT-PCR using a panel of archived samples collected during dengue surveillance. Study design: A retrospective analysis of 16,454 dengue IgM/IgG ELISA positive cases collected between 2000 and 2013 was done to investigate the sensitivity of the nested RT-PCR. From these cases, 318 acute serum specimens or extracted RNA, previously found to be negative by the nested RT-PCR, were tested using TaqMan real-time RT-PCR (TaqMan rRT-PCR). To improve the sensitivity of nested RT-PCR, we designed a new primer based on nucleotide sequences from contemporary strains found to be positive by the TaqMan rRT-PCR. Sensitivity of the new nested PCR was calculated using a panel of 87 samples collected during 2011-2013. Results and conclusion: The percentage of dengue IgM/IgG ELISA positive cases that were negative by the nested RT-PCR varied from 17% to 42% for all serotypes depending on the year. Using TaqMan rRT-PCR, dengue RNA was detected in 194 (61%) of the 318 acute sera or extracted RNA previously found to be negative by the nested RT-PCR. The newly designed DENV-1 specific primer increased the sensitivity of DENV-1 detection by the nested RT-PCR from 48% to 88%, and of all 4 serotypes from 73% to 87%. These findings demonstrate the impact of genetic diversity and signal erosion on the sensitivity of PCR-based methods. Published by Elsevier B.V. C1 [Klungthong, Chonticha; Manasatienkij, Wudtichai; Phonpakobsin, Thipwipha; Chinnawirotpisan, Piyawan; Rodpradit, Prinyada; Hussem, Kittinun; Thaisomboonsuk, Butsaya; Ong-ajchaowlerd, Prapapun; Nisalak, Ananda; Buddhari, Darunee; Yoon, In-Kyu; Fernandez, Stefan] Armed Forces Res Inst Med Sci, Dept Virol, Bangkok 10400, Thailand. [Kalayanarooj, Siripen] Queen Sin kit Natl Inst Child Hlth, Bangkok, Thailand. [Jarman, Richard G.] Walter Reed Army Inst Res, Viral Dis Branch, Silver Spring, MD USA. [Gibbons, Robert V.] US Army Inst Surg Res, JBSA Ft Sam Houston, TX USA. RP Klungthong, C (reprint author), Armed Forces Res Inst Med Sci, 315-6 Rajvithi Rd, Bangkok 10400, Thailand. EM Chontichak@afrims.org FU United States Army Medical Research and Materiel Command (Fort Detrick, Frederick, MD) FX This work was supported by the United States Army Medical Research and Materiel Command (Fort Detrick, Frederick, MD). NR 32 TC 1 Z9 1 U1 2 U2 4 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1386-6532 EI 1873-5967 J9 J CLIN VIROL JI J. Clin. Virol. PD FEB PY 2015 VL 63 BP 25 EP 31 DI 10.1016/j.jcv.2014.12.009 PG 7 WC Virology SC Virology GA AZ2BT UT WOS:000348040300005 PM 25600599 ER PT J AU Johnston, SC Johnson, JC Stonier, SW Lin, KL Kisalu, NK Hensley, LE Rimoin, AW AF Johnston, Sara C. Johnson, Joshua C. Stonier, Spencer W. Lin, Kenny L. Kisalu, Neville K. Hensley, Lisa E. Rimoin, Anne W. TI Cytokine modulation correlates with severity of monkeypox disease in humans SO JOURNAL OF CLINICAL VIROLOGY LA English DT Article DE Orthopoxvirus; Monkeypox; Cytokine; Cytokine storm; Regulatory T cell ID REGULATORY T-CELLS; VACCINIA VIRUS-INFECTION; MYASTHENIA-GRAVIS; SMALLPOX; SUPPRESSION; FOXP3(+); EXPRESSION; EXPANSION; RESPONSES; INHIBIT AB Background: Human monkeypox is a zoonotic disease endemic to parts of Africa. Similar to other orthopoxviruses, virus and host have considerable interactions through immunomodulation. These interactions likely drive the establishment of a productive infection and disease progression, resulting in the range of disease presentations and case fatality rates observed for members of the Orthopoxvirus genus. Objectives: Much of our understanding about the immune response to orthopoxvirus infection comes from either in vitro or in vivo studies performed in small animals or non-human primates. Here, we conducted a detailed assessment of cytokine responses to monkeypox virus using serum from acutely ill humans collected during monkeypox active disease surveillance (2005-2007) in the Democratic Republic of the Congo. Study design: Nineteen serum samples that were from patients with confirmed monkeypox virus infections were selected for cytokine profiling. Cytokine profiling was performed on the Bio-Rad Bioplex 100 system using a 30-plex human cytokine panel. Results: Cytokine profiling revealed elevated cytokine concentrations in all samples. Overproduction of certain cytokines (interleukin [IL]-2R, IL-10, and granulocyte macrophage-colony stimulating factor were observed in patients with serious disease (defined as >250 lesions based on the World Health Organization scoring system). Conclusions: The data suggest that cytokine modulation affects monkeypox disease severity in humans. (C) 2014 Elsevier B.V. All rights reserved. C1 [Johnston, Sara C.; Johnson, Joshua C.; Stonier, Spencer W.; Lin, Kenny L.; Hensley, Lisa E.] US Army, Med Res Inst Infect Dis, Div Virol, Ft Detrick, MD 21702 USA. [Kisalu, Neville K.] Univ Calif Los Angeles, Dept Microbiol Immunol & Mol Genet, Los Angeles, CA 90095 USA. [Rimoin, Anne W.] Univ Calif Los Angeles, Sch Publ Hlth, Dept Epidemiol, Los Angeles, CA 90024 USA. RP Rimoin, AW (reprint author), 650 Charles E Young Dr South,CHS 71-279B, Los Angeles, CA 90095 USA. EM arimoin@ucla.edu OI Johnson, Joshua/0000-0002-5677-3841 FU Defense Threat Reduction Agency [195726] FX This work was supported by the Defense Threat Reduction Agency [Project #195726]. Opinions, interpretations, conclusions, and recommendations are those of the author and are not necessarily endorsed by the U.S. Army. NR 24 TC 2 Z9 2 U1 0 U2 5 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1386-6532 EI 1873-5967 J9 J CLIN VIROL JI J. Clin. Virol. PD FEB PY 2015 VL 63 BP 42 EP 45 DI 10.1016/j.jcv.2014.12.001 PG 4 WC Virology SC Virology GA AZ2BT UT WOS:000348040300009 PM 25600603 ER PT J AU Jia, ZZ Sun, J Dobbs, H King, J AF Jia, Zhenzhong Sun, Jing Dobbs, Herb King, Joel TI Feasibility study of solid oxide fuel cell engines integrated with sprinter gas turbines: Modeling, design and control SO JOURNAL OF POWER SOURCES LA English DT Article DE Solid oxide fuel cell (SOFC); Gas turbine (GT); Load following; Design; Control analysis ID CONTROL STRATEGY; HYBRID SYSTEMS; POWER-PLANT; PERFORMANCE; OPERATION AB Conventional recuperating solid oxide fuel cell (SOFC)/gas turbine (GT) system suffers from its poor dynamic capability and load following performance. To meet the fast, safe and efficient load following requirements for mobile applications, a sprinter SOFC/GT system concept is proposed in this paper. In the proposed system, an SOFC stack operating at fairly constant temperature provides the baseline power with high efficiency while the fast dynamic capability of the GT-generator is fully explored for fast dynamic load following. System design and control studies have been conducted by using an SOFC/GT system model consisting of experimentally-verified component models. In particular, through analysis of the steady-state simulation results, an SOFC operation strategy is proposed to maintain fairly constant SOFC power (less than 2% power variation) and temperature (less than 2 K temperature variation) over the entire load range. A system design procedure well-suited to the proposed system has also been developed to help determining component sizes and the reference steady-state operation line. In addition, control analysis has been studied for both steady-state and transient operations. Simulation results suggest that the proposed system holds the promise to achieve fast and safe transient operations by taking full advantage of the fast dynamics of the GT-generator. (C) 2014 Elsevier B.V. All rights reserved. C1 [Jia, Zhenzhong; Sun, Jing] Univ Michigan, Dept Naval Architecture & Marine Engn NAME, Ann Arbor, MI 48109 USA. [Dobbs, Herb; King, Joel] US Army TARDEC, Nonprimary Power Syst Team, Warren, MI 48397 USA. RP Jia, ZZ (reprint author), Univ Michigan, Dept Naval Architecture & Marine Engn NAME, Ann Arbor, MI 48109 USA. EM zhenzjia@umich.edu; jingsun@umich.edu FU Automotive Research Center (US Army TARDEC) FX The authors would like to acknowledge the Automotive Research Center (US Army TARDEC) for the support of this research. NR 39 TC 4 Z9 4 U1 0 U2 20 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0378-7753 EI 1873-2755 J9 J POWER SOURCES JI J. Power Sources PD FEB 1 PY 2015 VL 275 BP 111 EP 125 DI 10.1016/j.jpowsour.2014.10.203 PG 15 WC Chemistry, Physical; Electrochemistry; Energy & Fuels; Materials Science, Multidisciplinary SC Chemistry; Electrochemistry; Energy & Fuels; Materials Science GA AZ2UT UT WOS:000348088400017 ER PT J AU Taylor, S Bigl, S Packer, B AF Taylor, Susan Bigl, Susan Packer, Bonnie TI Condition of in situ unexploded ordnance SO SCIENCE OF THE TOTAL ENVIRONMENT LA English DT Article DE Unexploded ordnance; Explosives; Soil sampling; Pitting corrosion; Oxidation ID RANGES AB Unexploded ordnance (UXO) become point contamination sources when their casings fail and their explosive fill dissolve. To determine the modes of failure, we documented the condition of UXO found on military training ranges and sampled soils for explosives beneath 42 in situ UXO. We found that oxidation caused the metal UXO casings to swell and fail catastrophically. Unlike previous work, pitting of the metal casings was not found to be an important release route for explosives. Of the 42 UXO sampled, eight were leaking explosives into the soil and of these, four had perforated or cracked casings, three were corroded and one was a partially detonated round. We estimated a surface density of 74 UXO per hectare for a subset of UXO sampled. We used the relative concentrations of explosives and their transformation products in the soil to determine if the explosives had recently dissolved or were from past military training. Published by Elsevier B.V. C1 [Taylor, Susan; Bigl, Susan] US Army, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. [Packer, Bonnie] ARNG ILE C, Arlington, VA 22204 USA. RP Taylor, S (reprint author), US Army, Cold Reg Res & Engn Lab, 72 Lyme Rd, Hanover, NH 03755 USA. EM Susan.Taylor@usace.army.mil FU U.S. Army Environmental Command; CH2MHill Inc. FX The authors thank the U.S. Army Environmental Command for funding this work and Kim Watts the project managers. We thank Jim Hug and Christopher Graber, our unexploded ordnance team, for keeping us safe. Thanks to Michael and Marianne Walsh for suggesting sampling locations in Alaska. We appreciate the support provided by personnel with CH2MHill Inc., responsible for remediating the Vieques Naval Training Range, in particular Philip Fitzwater, Tim Garretson, and Billy Capstick. We thank Madeline Riviera, the Navy coordinator at Vieques, for providing access to range records and Jae Yun, the Parsons site manager who helped us with access to the San Luis Obispo, CA site. Finally, this paper was substantially improved by the comments provided to us by three anonymous reviewers. NR 21 TC 3 Z9 3 U1 0 U2 7 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0048-9697 EI 1879-1026 J9 SCI TOTAL ENVIRON JI Sci. Total Environ. PD FEB 1 PY 2015 VL 505 BP 762 EP 769 DI 10.1016/j.scitotenv.2014.10.059 PG 8 WC Environmental Sciences SC Environmental Sciences & Ecology GA AY6CJ UT WOS:000347654900077 PM 25461079 ER PT J AU Boedihardjo, AP Lu, CT Chen, F AF Boedihardjo, Arnold P. Lu, Chang-Tien Chen, Feng TI Fast adaptive kernel density estimator for data streams SO KNOWLEDGE AND INFORMATION SYSTEMS LA English DT Article DE Data mining; Data streams; Kernel density estimation AB The probability density function (PDF) is an effective data model for a variety of stream mining tasks. As such, accurate estimates of the PDF are essential to reducing the uncertainties and errors associated with mining results. The nonparametric adaptive kernel density estimator (AKDE) provides accurate, robust, and asymptotically consistent estimates of a PDF. However, due to AKDE's extensive computational requirements, it cannot be directly applied to the data stream environment. This paper describes the development of an AKDE approximation approach that heeds the constraints of the data stream environment and supports efficient processing of multiple queries. To this end, this work proposes (1) the concept of local regions to provide a partition-based variable bandwidth to capture local density structures and enhance estimation quality; (2) a suite of linear-pass methods to construct the local regions and kernel objects online; (3) an efficient multiple queries evaluation algorithm; (4) a set of approximate techniques to increase the throughput of multiple density queries processing; and (5) a fixed-size memory time-based sliding window that updates the kernel objects in linear time. Comprehensive experiments were conducted with real-world and synthetic data sets to validate the effectiveness and efficiency of the approach. C1 [Boedihardjo, Arnold P.] US Army Corps Engineers, Alexandria, VA 22315 USA. [Lu, Chang-Tien] Virginia Tech, Dept Comp Sci, Falls Church, VA USA. [Chen, Feng] Carnegie Melon Univ, Dept Comp Sci, Pittsburgh, PA USA. RP Boedihardjo, AP (reprint author), US Army Corps Engineers, Alexandria, VA 22315 USA. EM arnold.p.boedihardjo@usace.army.mil; ctlu@vt.edu; fchen1@andrew.cmu.edu NR 35 TC 1 Z9 1 U1 0 U2 11 PU SPRINGER LONDON LTD PI LONDON PA 236 GRAYS INN RD, 6TH FLOOR, LONDON WC1X 8HL, ENGLAND SN 0219-1377 EI 0219-3116 J9 KNOWL INF SYST JI Knowl. Inf. Syst. PD FEB PY 2015 VL 42 IS 2 BP 285 EP 317 DI 10.1007/s10115-013-0712-0 PG 33 WC Computer Science, Artificial Intelligence; Computer Science, Information Systems SC Computer Science GA AY8AH UT WOS:000347776300002 ER PT J AU Prager, EM Figueiredo, TH Long, RP Aroniadou-Anderjaska, V Apland, JP Braga, MFM AF Prager, Eric M. Figueiredo, Taiza H. Long, Robert P., II Aroniadou-Anderjaska, Vassiliki Apland, James P. Braga, Maria F. M. TI LY293558 prevents soman-induced pathophysiological alterations in the basolateral amygdala and the development of anxiety SO NEUROPHARMACOLOGY LA English DT Article DE Soman; LY293558; Basolateral amygdala; Anxiety; Long-term potentiation; Paired-pulse ratio ID POSTTRAUMATIC-STRESS-DISORDER; ORGANOPHOSPHORUS NERVE AGENTS; RECEPTOR ANTAGONIST LY293558; INDUCED SEIZURE ACTIVITY; LONG-TERM POTENTIATION; STATUS EPILEPTICUS; GABA(A) RECEPTORS; ACOUSTIC STARTLE; ELECTRICAL-STIMULATION; KAINATE RECEPTORS AB Exposure to nerve agents can cause brain damage due to prolonged seizure activity, producing long-term behavioral deficits. We have previously shown that LY293558, a GluK1/AMPA receptor antagonist, is a very effective anticonvulsant and neuroprotectant against nerve agent exposure. In the present study, we examined whether the protection against nerve agent-induced seizures and neuropathology conferred by LY293558 translates into protection against pathophysiological alterations in the basolateral amygdala (BLA) and the development of anxiety, which is the most prevalent behavioral deficit resulting from exposure. LY293558 (15 mg/1