FN Thomson Reuters Web of Science™
VR 1.0
PT J
AU Wang, GX
Pandey, R
Karna, SP
AF Wang, Gaoxue
Pandey, Ravindra
Karna, Shashi P.
TI Effects of extrinsic point defects in phosphorene: B, C, N, O, and F
adatoms
SO APPLIED PHYSICS LETTERS
LA English
DT Article
ID LAYER BLACK PHOSPHORUS; FIELD-EFFECT TRANSISTORS; SILICENE; MONOLAYER
AB Phosphorene is emerging as a promising 2D semiconducting material with a direct band gap and high carrier mobility. In this paper, we examine the role of the extrinsic point defects including surface adatoms in modifying the electronic properties of phosphorene using density functional theory. The surface adatoms considered are B, C, N, O, and F with a [He] core electronic configuration. Our calculations show that B and C, with electronegativity close to P, prefer to break the sp 3 bonds of phosphorene and reside at the interstitial sites in the 2D lattice by forming sp 2 like bonds with the native atoms. On the other hand, N, O, and F, which are more electronegative than P, prefer the surface sites by attracting the lone pairs of phosphorene. B, N, and F adsorption will also introduce local magnetic moment to the lattice. Moreover, B, C, N, and F adatoms will modify the band gap of phosphorene, yielding metallic transverse tunneling characters. Oxygen does not modify the band gap of phosphorene, and a diode like tunneling behavior is observed. Our results therefore offer a possible route to tailor the electronic and magnetic properties of phosphorene by the adatom functionalization and provide the physical insights of the environmental sensitivity of phosphorene, which will be helpful to experimentalists in evaluating the performance and aging effects of phosphorene-based electronic devices. (C) 2015 AIP Publishing LLC.
C1 [Wang, Gaoxue; Pandey, Ravindra] Michigan Technol Univ, Dept Phys, Houghton, MI 49931 USA.
[Karna, Shashi P.] US Army Res Lab, Weap & Mat Res Directorate, ATTN RDRL WM, Aberdeen Proving Ground, MD 21005 USA.
RP Wang, GX (reprint author), Michigan Technol Univ, Dept Phys, Houghton, MI 49931 USA.
EM gaoxuew@mtu.edu; pandey@mtu.edu; shashi.p.karna.civ@mail.mil
RI Wang, Gaoxue/C-9492-2017
OI Wang, Gaoxue/0000-0003-2539-3405
FU Army Research Office [W911NF-14-2-0088]
FX The authors are grateful to Dr. S. Gowtham for his support. This
research was partially supported by the Army Research Office through
Grant No. W911NF-14-2-0088. RAMA and Superior, high performance
computing clusters at Michigan Technological University, were used in
obtaining results presented in this paper.
NR 42
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U2 105
PU AMER INST PHYSICS
PI MELVILLE
PA 1305 WALT WHITMAN RD, STE 300, MELVILLE, NY 11747-4501 USA
SN 0003-6951
EI 1077-3118
J9 APPL PHYS LETT
JI Appl. Phys. Lett.
PD APR 27
PY 2015
VL 106
IS 17
AR 173104
DI 10.1063/1.4919389
PG 5
WC Physics, Applied
SC Physics
GA CH2ES
UT WOS:000353839100047
ER
PT J
AU Welkos, SL
Klimko, CP
Kern, SJ
Bearss, JJ
Bozue, JA
Bernhards, RC
Trevino, SR
Waag, DM
Amemiya, K
Worsham, PL
Cote, CK
AF Welkos, Susan L.
Klimko, Christopher P.
Kern, Steven J.
Bearss, Jeremy J.
Bozue, Joel A.
Bernhards, Robert C.
Trevino, Sylvia R.
Waag, David M.
Amemiya, Kei
Worsham, Patricia L.
Cote, Christopher K.
TI Characterization of Burkholderia pseudomallei Strains Using a Murine
Intraperitoneal Infection Model and In Vitro Macrophage Assays
SO PLOS ONE
LA English
DT Article
ID EXPERIMENTAL MELIOIDOSIS; CAPSULAR POLYSACCHARIDE; INTRACELLULAR
SURVIVAL; COLONY MORPHOLOGY; YERSINIA-PESTIS; PULMONARY MELIOIDOSIS;
VIRULENCE FACTORS; B. THAILANDENSIS; RISK-FACTORS; LIPOPOLYSACCHARIDE
AB Burkholderia pseudomallei, the etiologic agent of melioidosis, is a gram-negative facultative intracellular bacterium. This bacterium is endemic in Southeast Asia and Northern Australia and can infect humans and animals by several routes. It has also been estimated to present a considerable risk as a potential biothreat agent. There are currently no effective vaccines for B. pseudomallei, and antibiotic treatment can be hampered by nonspecific symptomology, the high incidence of naturally occurring antibiotic resistant strains, and disease chronicity. Accordingly, there is a concerted effort to better characterize B. pseudomallei and its associated disease. Before novel vaccines and therapeutics can be tested in vivo, a well characterized animal model is essential. Previous work has indicated that mice may be a useful animal model. In order to develop standardized animal models of melioidosis, different strains of bacteria must be isolated, propagated, and characterized. Using a murine intraperitoneal (IP) infection model, we tested the virulence of 11 B. pseudomallei strains. The IP route offers a reproducible way to rank virulence that can be readily reproduced by other laboratories. This infection route is also useful in distinguishing significant differences in strain virulence that may be masked by the exquisite susceptibility associated with other routes of infection (e.g., inhalational). Additionally, there were several pathologic lesions observed in mice following IP infection. These included varisized abscesses in the spleen, liver, and haired skin. This model indicated that commonly used laboratory strains of B. pseudomallei (i.e., K96243 and 1026b) were significantly less virulent as compared to more recently acquired clinical isolates. Additionally, we characterized in vitro strain-associated differences in virulence for macrophages and described a potential inverse relationship between virulence in the IP mouse model of some strains and in the macrophage phagocytosis assay. Strains which were more virulent for mice (e.g., HBPU10304a) were often less virulent in the macrophage assays, as determined by several parameters such as intracellular bacterial replication and host cell cytotoxicity.
C1 [Welkos, Susan L.; Klimko, Christopher P.; Bozue, Joel A.; Bernhards, Robert C.; Trevino, Sylvia R.; Waag, David M.; Amemiya, Kei; Worsham, Patricia L.; Cote, Christopher K.] US Army, Med Res Inst Infect Dis, Bacteriol Div, Frederick, MD 21701 USA.
[Kern, Steven J.] US Army, Med Res Inst Infect Dis, Div Biostat, Frederick, MD USA.
[Bearss, Jeremy J.] US Army, Med Res Inst Infect Dis, Vet Pathol Div, Frederick, MD USA.
RP Cote, CK (reprint author), US Army, Med Res Inst Infect Dis, Bacteriol Div, Frederick, MD 21701 USA.
EM christopher.k.cote.civ@mail.mil
OI Bearss, David/0000-0002-4280-5670
FU Medical Biological Defense Research Program; Defense Threat Reduction
Agency (DTRA)
FX This research was funded by the Medical Biological Defense Research
Program; Defense Threat Reduction Agency (DTRA). The funders had a role
in selecting the bacterial strains which comprised the B. pseudomallei
strain panel examined in this work.
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PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD APR 24
PY 2015
VL 10
IS 4
AR e0124667
DI 10.1371/journal.pone.0124667
PG 24
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA CG6AH
UT WOS:000353376800098
PM 25909629
ER
PT J
AU De Souza, MS
Phanuphak, N
Pinyakorn, S
Trichavaroj, R
Pattanachaiwit, S
Chomchey, N
Fletcher, JL
Kroon, ED
Michael, NL
Phanuphak, P
Kim, JH
Ananworanich, J
AF De Souza, Mark S.
Phanuphak, Nittaya
Pinyakorn, Suteeraporn
Trichavaroj, Rapee
Pattanachaiwit, Supanit
Chomchey, Nitiya
Fletcher, James L.
Kroon, Eugene D.
Michael, Nelson L.
Phanuphak, Praphan
Kim, Jerome H.
Ananworanich, Jintanat
CA SEARCH 010 Study Grp
TI Impact of nucleic acid testing relative to antigen/antibody combination
immunoassay on the detection of acute HIV infection
SO AIDS
LA English
DT Article
DE acute HIV infection; Bangkok; Fiebig; HIV antigen; antibody combination
assay; pooled nucleic acid testing
ID AG/AB COMBO ASSAY; P24 ANTIGEN; TRANSMISSION; RNA; POPULATION;
SENSITIVITY; PERFORMANCE; STRATEGIES; ALGORITHM; SPECIMENS
AB Objective:To assess the addition of HIV nucleic acid testing (NAT) to fourth-generation (4thG) HIV antigen/antibody combination immunoassay in improving detection of acute HIV infection (AHI).Methods:Participants attending a major voluntary counseling and testing site in Thailand were screened for AHI using 4thG HIV antigen/antibody immunoassay and sequential less sensitive HIV antibody immunoassay. Samples nonreactive by 4thG antigen/antibody immunoassay were further screened using pooled NAT to identify additional AHI. HIV infection status was verified following enrollment into an AHI study with follow-up visits and additional diagnostic tests.Results:Among 74334 clients screened for HIV infection, HIV prevalence was 10.9% and the overall incidence of AHI (N=112) was 2.2 per 100 person-years. The inclusion of pooled NAT in the testing algorithm increased the number of acutely infected patients detected, from 81 to 112 (38%), relative to 4thG HIV antigen/antibody immunoassay. Follow-up testing within 5 days of screening marginally improved the 4thG immunoassay detection rate (26%). The median CD4(+) T-cell count at the enrollment visit was 353cells/l and HIV plasma viral load was 598289copies/ml.Conclusion:The incorporation of pooled NAT into the HIV testing algorithm in high-risk populations may be beneficial in the long term. The addition of pooled NAT testing resulted in an increase in screening costs of 22% to identify AHI: from $8.33 per screened patient to $10.16. Risk factors of the testing population should be considered prior to NAT implementation given the additional testing complexity and costs.
C1 [De Souza, Mark S.; Phanuphak, Nittaya; Pinyakorn, Suteeraporn; Chomchey, Nitiya; Fletcher, James L.; Kroon, Eugene D.; Phanuphak, Praphan; Ananworanich, Jintanat] SEARCH, Bangkok, Thailand.
[De Souza, Mark S.; Phanuphak, Nittaya; Pinyakorn, Suteeraporn; Pattanachaiwit, Supanit; Chomchey, Nitiya; Fletcher, James L.; Kroon, Eugene D.; Phanuphak, Praphan] Thai Red Cross AIDS Res Ctr, Bangkok 10330, Thailand.
[De Souza, Mark S.] Cooper Human Syst, Nashua, NH USA.
[Pinyakorn, Suteeraporn; Phanuphak, Praphan] HIV NAT, Bangkok, Thailand.
[Trichavaroj, Rapee; Kroon, Eugene D.] Armed Forces Res Inst Med Sci, Dept Retrovirol, US Component, Bangkok, Thailand.
[Michael, Nelson L.; Kim, Jerome H.; Ananworanich, Jintanat] US Mil HIV Res Program, Bethesda, MD USA.
[Michael, Nelson L.; Kim, Jerome H.] Walter Reed Army Inst Res, Silver Spring, MD USA.
[Ananworanich, Jintanat] Henry M Jackson Fdn Adv Mil Med, Bethesda, MD USA.
RP De Souza, MS (reprint author), Thai Red Cross AIDS Res Ctr, SEARCH, Tower 2,2nd Floor,104 Rajdumri Rd, Bangkok 10330, Thailand.
EM markdes@searchthailand.org
FU US Military HIV Research Program; Walter Reed Army Institute of
Research, Rockville, Maryland [W81XWH-07-2-0067]
FX Funding source: The study was funded by the US Military HIV Research
Program, Walter Reed Army Institute of Research, Rockville, Maryland,
under a cooperative agreement (W81XWH-07-2-0067) between the Henry M.
Jackson Foundation for the Advancement of Military Medicine, Inc., and
the US Department of Defense.
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U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0269-9370
EI 1473-5571
J9 AIDS
JI Aids
PD APR 24
PY 2015
VL 29
IS 7
BP 793
EP 800
DI 10.1097/QAD.0000000000000616
PG 8
WC Immunology; Infectious Diseases; Virology
SC Immunology; Infectious Diseases; Virology
GA CG7FV
UT WOS:000353469000005
PM 25985402
ER
PT J
AU Beske, PH
Scheeler, SM
Adler, M
McNutt, PM
AF Beske, Phillip H.
Scheeler, Stephen M.
Adler, Michael
McNutt, Patrick M.
TI Accelerated intoxication of GABAergic synapses by botulinum neurotoxin A
disinhibits stem cell-derived neuron networks prior to network silencing
SO FRONTIERS IN CELLULAR NEUROSCIENCE
LA English
DT Article
DE botulinum neurotoxin; stem cell-derived neurons; SNAP-25; synaptic
transmission; glutamatergic synapse; GABAergic synapse; botulism
ID IN-VITRO; SEROTYPE-A; SNAP-25; TOXIN; RAT; INHIBITION;
NEUROTRANSMISSION; IDENTIFICATION; THERAPEUTICS; ENDOCYTOSIS
AB Botulinum neurotoxins (BoNTs) are extremely potent toxins that specifically cleave SNARE proteins in peripheral synapses, preventing neurotransmitter release. Neuronal responses to BoNT intoxication are traditionally studied by quantifying SNARE protein cleavage in vitro or monitoring physiological paralysis in vivo. Consequently, the dynamic effects of intoxication on synaptic behaviors are not well-understood. We have reported that mouse embryonic stem cell-derived neurons (ESNs) are highly sensitive to BoNT based on molecular readouts of intoxication. Here we study the time-dependent changes in synapse- and network-level behaviors following addition of BoNT/A to spontaneously active networks of glutamatergic and GABAergic ESNs. Whole-cell patch-clamp recordings indicated that BoNT/A rapidly blocked synaptic neurotransmission, confirming that ESNs replicate the functional pathophysiology responsible for clinical botulism. Quantitation of spontaneous neurotransmission in pharmacologically isolated synapses revealed accelerated silencing of GABAergic synapses compared to glutamatergic synapses, which was consistent with the selective accumulation of cleaved SNAP-25 at GAD1(+) pre-synaptic terminals at early timepoints. Different latencies of intoxication resulted in complex network responses to BoNT/A addition, involving rapid disinhibition of stochastic firing followed by network silencing. Synaptic activity was found to be highly sensitive to SNAP-25 cleavage, reflecting the functional consequences of the localized cleavage of the small subpopulation of SNAP-25 that is engaged in neurotransmitter release in the nerve terminal. Collectively these findings illustrate that use of synaptic function assays in networked neurons cultures offers a novel and highly sensitive approach for mechanistic studies of toxin:neuron interactions and synaptic responses to BoNT.
C1 [Beske, Phillip H.; Scheeler, Stephen M.; Adler, Michael; McNutt, Patrick M.] US Army, Med Res Inst Chem Def, Cellular & Mol Biol Branch, Div Res, Aberdeen Proving Ground, MD 21010 USA.
RP McNutt, PM (reprint author), US Army, Med Res Inst Chem Def, 3100 Ricketts Point Rd, Aberdeen Proving Ground, MD 21010 USA.
EM patrick.m.mcnutt2.civ@mail.mil
OI McNutt, Patrick/0000-0002-5703-4565
FU National Institutes of Health National Institute of Allergy and
Infectious Diseases (IAA) [A0D12058-0001-0000]; Defense Threat Reduction
Agency-Joint Science and Technology Office, Medical ST Division
[CBM.THRTOX.01.10.RC.023, CBM.THRTOX.01.RC.014]; Defense Threat
Reduction Agency-National Research Council Research Associateship Award
FX This work was funded by the National Institutes of Health National
Institute of Allergy and Infectious Diseases (IAA number
A0D12058-0001-0000) and the Defense Threat Reduction Agency-Joint
Science and Technology Office, Medical S&T Division (grant numbers
CBM.THRTOX.01.10.RC.023 and CBM.THRTOX.01.RC.014). This research was
performed while PB held a Defense Threat Reduction Agency-National
Research Council Research Associateship Award.
NR 48
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U1 0
U2 1
PU FRONTIERS RESEARCH FOUNDATION
PI LAUSANNE
PA PO BOX 110, LAUSANNE, 1015, SWITZERLAND
SN 1662-5102
J9 FRONT CELL NEUROSCI
JI Front. Cell. Neurosci.
PD APR 23
PY 2015
VL 9
AR 159
DI 10.3389/fncel.2015.00159
PG 12
WC Neurosciences
SC Neurosciences & Neurology
GA CI5LA
UT WOS:000354796400001
PM 25954159
ER
PT J
AU Read, JA
AF Read, Jeffrey A.
TI In-Situ Studies on the Electrochemical Intercalation of
Hexafluorophosphate Anion in Graphite with Selective Cointercalation of
Solvent
SO JOURNAL OF PHYSICAL CHEMISTRY C
LA English
DT Article
ID REVERSIBLE INTERCALATION; ELECTROLYTES; CELLS; SPECTROSCOPY;
PYROGRAPHITE; FLUORIDES; CARBONATE; OXIDATION; BEHAVIOR; BATTERY
AB Electrochemical cells utilizing graphite intercalation compounds at both electrodes have been proposed as an energy storage technology where the electrolyte salt is split and stored in the electrodes on Charge and reformed on discharge. The anion intercalation compounds of graphite proposed as cathodes in these systems have been studied in electrolytes that are resistant to oxidation at 5 V but that are incompatible with graphite anodes, Recent work has demonstrated that electrolytes based Ion monofluoroethylene carbonate (FEC) and ethylmethyl carbonate (EMC) have superior oxidative stability on graphite cathodes over previously studied electrolytes and form a stable, solid electrolyte interphase (SEI), on graphite anodes that allow for full dual-graphite cells to be evaluated for energy storage applications. There is still a limited understanding as to structure of the anion intercalate formed in these electrolyte systems and the effect of solvent cointercalation on cathode performance. This effort was undertaken using a number of in situ techniques to better characterize the fully intercalated composition as well as to investigate the process of solvent cointercalation: It was shown that a series of stages based on the C24PF6 composition are formed until, upon reaching full charge, the structure approaches a C20PF6 stage I composition with PF6- anion in close contact with the graphite layers and 0.7 molecules of cointercalated solvent. For the first time, we have shown that solvent molecules move with anion during the intercalation/deintercalation process while analysis of fully intercalated crystals demonstrated that there is an unusually strong preference for EMC over FEC to cointercalate in this anion intercalation compound.
C1 US Army, Res Lab, Adelphi, MD 20783 USA.
RP Read, JA (reprint author), US Army, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA.
EM jeffrey.a.read4.civ@mail.mil
FU Army Research Laboratory
FX The author would like to acknowledge Dr. Janet Ho for help with
dilatometry, Dr. Jan Allen for helpful discussion on XRD indexing, Dr.
Kang Xu, and Dr. Arthur Cresce for electrolytes and the US Army Research
Laboratory for financial support.
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U2 59
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 1932-7447
J9 J PHYS CHEM C
JI J. Phys. Chem. C
PD APR 23
PY 2015
VL 119
IS 16
BP 8438
EP 8446
DI 10.1021/jp5115465
PG 9
WC Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science,
Multidisciplinary
SC Chemistry; Science & Technology - Other Topics; Materials Science
GA CG8ZF
UT WOS:000353603500003
ER
PT J
AU Han, SD
Yun, SH
Borodin, O
Seo, DM
Sommer, RD
Young, VG
Henderson, WA
AF Han, Sang-Don
Yun, Sun-Hyun
Borodin, Oleg
Seo, Daniel M.
Sommer, Roger D.
Young, Victor G., Jr.
Henderson, Wesley A.
TI Solvate Structures and Computational/Spectroscopic Characterization of
LiPF6 Electrolytes
SO JOURNAL OF PHYSICAL CHEMISTRY C
LA English
DT Article
ID HIGHLY ASSOCIATED SALTS; RAY CRYSTAL-STRUCTURE; IONIC ASSOCIATION;
LITHIUM HEXAFLUOROPHOSPHATE; VIBRATIONAL FREQUENCIES; MIXTURES;
COMPLEXES; CHEMISTRY; CATION; CARBONATES
AB Raman spectroscopy is a powerful method for identifying ion-ion interactions, but only if the vibrational band signatures for the anion coordination modes can be accurately deciphered. The present study characterizes the PF6- anion P-F Raman symmetric stretching vibrational band for evaluating the PF6-center dot center dot center dot Li+ cation interactions within LiPF6 crystalline solvates to create a characterization tool for liquid electrolytes. To facilitate this, the crystal structures for two new solvates-(G3)(1):LiPF6 and (DEC)(2):LiPF6 with triglyme and diethyl carbonate, respectively-are reported. DFT calculations for Li-PF6 solvates have been used to aid in the assignments. of the spectroscopic signatures. The information,,obtained from this analysis provides key guidance about the ionic,association information which may be obtained from a Raman spectroscopic evaluation of electrolytes containing the LiPF6 salt and aprotic solvents. Of particular note is the overlap of the Raman bands for both solvent-separated ion pair (SSIP) and contact ion pair (CIP) coordination In which the PF6- anions are uncoordinated or coordinated to a single Li+ cation, respectively.
C1 [Han, Sang-Don; Yun, Sun-Hyun; Seo, Daniel M.; Henderson, Wesley A.] N Carolina State Univ, Dept Chem & Biomol Engn, Ion Liquids & Elect Energy Technol ILEET Lab, Raleigh, NC 27695 USA.
[Yun, Sun-Hyun] GIST, Sch Environm Sci & Engn, Gwangju 500712, South Korea.
[Borodin, Oleg] US Army, Electrochem Branch, Res Lab, Adelphi, MD 20783 USA.
[Sommer, Roger D.] N Carolina State Univ, Dept Chem, Xray Struct Facil, Raleigh, NC 27695 USA.
[Young, Victor G., Jr.] Univ Minnesota, Dept Chem, Xray Crystallog Lab, Minneapolis, MN 55455 USA.
[Henderson, Wesley A.] PNNL, Energy & Environm Directorate, Electrochem Mat & Syst Grp, Richland, WA 99352 USA.
RP Borodin, O (reprint author), US Army, Electrochem Branch, Res Lab, Adelphi, MD 20783 USA.
EM oleg.a.borodin.civ@mail.mil; wesley.henderson@pnnl.gov
RI Borodin, Oleg/B-6855-2012
OI Borodin, Oleg/0000-0002-9428-5291
FU U.S. Department of Energy (DOE) Batteries for Advanced Transportation
Technologies (BATT) Program [DE-AC02-05-CH11231]; Department of
Chemistry of North Carolina State University; State of North Carolina
FX The authors wish to express their gratitude to the U.S. Department of
Energy (DOE) Batteries for Advanced Transportation Technologies (BATT)
Program which fully supported the experimental portion of this research
under Award Number DE-AC02-05-CH11231. The authors also wish to thank
the Department of Chemistry of North Carolina State University and the
State of North Carolina for funding the purchase of the Apex2
diffractometer.
NR 41
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U1 2
U2 32
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 1932-7447
J9 J PHYS CHEM C
JI J. Phys. Chem. C
PD APR 23
PY 2015
VL 119
IS 16
BP 8492
EP 8500
DI 10.1021/acs.jpcc.5b00826
PG 9
WC Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science,
Multidisciplinary
SC Chemistry; Science & Technology - Other Topics; Materials Science
GA CG8ZF
UT WOS:000353603500010
ER
PT J
AU Korotchenko, V
Sathunuru, R
Gerena, L
Caridha, D
Li, QG
Kreishman-Deitrick, M
Smith, PL
Lin, AJ
AF Korotchenko, Vasiliy
Sathunuru, Ramadas
Gerena, Lucia
Caridha, Diana
Li, Qigui
Kreishman-Deitrick, Mara
Smith, Philip L.
Lin, Ai J.
TI Antimalarial Activity of 4-Amidinoquinoline and
10-Amidinobenzonaphthyridine Derivatives
SO JOURNAL OF MEDICINAL CHEMISTRY
LA English
DT Article
ID QT-INTERVAL PROLONGATION; PLASMODIUM-FALCIPARUM; CHLOROQUINE-RESISTANCE;
IN-VITRO; 4-AMINOQUINOLINE ANALOGS; HEMOZOIN FORMATION; BETA-HEMATIN;
SIDE-CHAIN; AMODIAQUINE; MALARIA
AB Chloroquine (CQ) has been used as first line malaria therapeutic drug for decades. Emergence of CQ drug-resistant Plasmodium falciparum malaria throughout endemic areas of the world has limited its clinical value. Mefloquine (MQ) has been used as an effective malaria prophylactic drug due to its being long-acting and having a high potency against blood stage P. falciparum (Pf). However, serious CNS toxicity of MQ has compromised its clinical value as a prophylaxis drug. Therefore, new and inexpensive antimalarial drugs with no cross-resistance to CQ or CNS toxicity are urgently needed to combat this deadly human disease. In this study, a series of new 4-amidinoquinoline (4-AMQ) and 10-amidinobenzonaphthyridine (10-AMB) derivatives were designed, prepared, and assessed to search for new therapeutic agents to replace CQ and MQ. The new derivatives displayed high activity in vitro and in vivo, with no cross-resistance to CQ, and none were toxic in mice up to 160 mpk X 3. The best compound shows IC50 < 1 ng/mL against D6, W2 and C235 Pf clones, low inhibitory activity in hERG K+ channel blockage testing, negativity in the Ames test, and 5/5 cure @ <15 mpk X 3 in mice infected with Plasmodium berghei. In addition to these desirable pharmacological profiles, compound 13b, one of the most active compounds, is metabolically stable in both human and mouse liver microsomal preparations and has a plasma t(1/2) of 50 h in mice, which made it a good MQ replacement candidate.
C1 [Korotchenko, Vasiliy; Sathunuru, Ramadas; Gerena, Lucia; Caridha, Diana; Li, Qigui; Kreishman-Deitrick, Mara; Smith, Philip L.; Lin, Ai J.] Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD 20910 USA.
RP Lin, AJ (reprint author), Walter Reed Army Inst Res, Div Expt Therapeut, 503 Robert Grant Ave, Silver Spring, MD 20910 USA.
EM aijeng@aol.com
FU Military Infectious Diseases Research Program, U.S. Army Medical
Research and Materiel Command, Department of Defense, U.S.A [Q282_12_WR]
FX The opinions or assertions contained herein are the private views of the
authors, and are not to be construed as official, or as reflecting true
views of the U.S. Army or the Department of Defense. This research is
supported by Grant No. Q282_12_WR, entitled "Hit to Lead Identification
of NCEs", from the Military Infectious Diseases Research Program, U.S.
Army Medical Research and Materiel Command, Department of Defense,
U.S.A. The authors are grateful to CPT Sean Marcsisin, ThuLan Luong,
Raul Olmeda, and Delaney Hettithantrige for assistance in metabolic
stability studies of the new compounds.
NR 72
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U1 3
U2 14
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0022-2623
EI 1520-4804
J9 J MED CHEM
JI J. Med. Chem.
PD APR 23
PY 2015
VL 58
IS 8
BP 3411
EP 3431
DI 10.1021/jm501809x
PG 21
WC Chemistry, Medicinal
SC Pharmacology & Pharmacy
GA CG8YS
UT WOS:000353602200010
PM 25654185
ER
PT J
AU Strack, OE
Leavy, RB
Brannon, RM
AF Strack, O. E.
Leavy, R. B.
Brannon, R. M.
TI Aleatory uncertainty and scale effects in computational damage models
for failure and fragmentation
SO INTERNATIONAL JOURNAL FOR NUMERICAL METHODS IN ENGINEERING
LA English
DT Article
DE constitutive equations; damage; fracture and fragmentation; fuzzy
probabilistic methods; impact; rate dependence; scale/size effects; mesh
dependence; verification; validation
ID DYNAMIC FRAGMENTATION; BRITTLE MATERIALS; SILICON-CARBIDE;
BORON-CARBIDE; STRAIN RATES; MECHANICS; FRACTURE; STRENGTH; ELEMENT;
IMPACT
AB Stress concentrations near grain boundaries, precipitates, and similar micro-heterogeneities nucleate instabilities leading to macroscale fracture. As it is not practical to model each flaw explicitly, their ensemble effect is modeled statistically. Accounting for this aleatory uncertainty requires smaller specimens (e.g., small finite elements) to have generally higher and more variable strengths, which is necessary for the initial failure probability of a finite domain to be unaffected by its discretization into elements. Localization itself, which might be attributed to constitutive instability, requires realistic numerical perturbations to predict bifurcations such as radial cracking in axisymmetric problems. These perturbations, stemming from microscale heterogeneity, are incorporated in simulations by imposing statistical spatial variability in the parameters of an otherwise conventional (deterministic and scale - independent) damage model. This approach is attractive for its algorithmic simplicity and straightforward calibration from standard strength tests. In addition, it results in virtually no loss of efficiency or robustness relative to deterministic models and accommodates general three - dimensional loading. Despite these advantages, some significant challenges remain and are discussed. However, it is demonstrated that including aleatory uncertainty with associated scale effects significantly improves predictiveness on large - scale computational domains, where it is impractical to resolve each crack or localization zone. Copyright (C) 2014 John Wiley & Sons, Ltd.
C1 [Strack, O. E.] Sandia Natl Labs, Computat Shock & Multiphys, Albuquerque, NM 87185 USA.
[Leavy, R. B.] Army Res Lab, Impact Phys, Aberdeen Proving Ground, MD USA.
[Brannon, R. M.] Univ Utah, Mech Engn, Salt Lake City, UT 84105 USA.
RP Brannon, RM (reprint author), Univ Utah, Mech Engn, Salt Lake City, UT 84105 USA.
EM Rebecca.Brannon@utah.edu
FU US Department of Energy's National Nuclear Security Administration
[DE-AC04-94AL85000, SAND2014-0865J]
FX In addition to administrative, technical, and financial support by
Sandia laboratory managers (especially Tom Pfeifle and Randy Summers)
and Army Research Laboratory managers (especially Bill Bruchey, Scott
Schoenfeld, and Todd Bjerke), funding and support for this work provided
by TACOM Project Manager John Rowe is deeply appreciated. We are
additionally grateful to the following individuals: Rich Becker (for his
2002 unpublished study of the effect of strength perturbations in plane
stress), Tracy Vogler and Lalit Chhabildas (for providing data and
constructive feedback), Richard Jensen and Josh Houskamp (for exercising
the model in Brazilian simulations and beta-testing), Moo Lee and David
Bronowski (for Brazilian and Triaxial testing of SiC-N ceramics), Mike
Veilleux (for Monte Carlo verification testing of the Weibull
perturbations), and Tim Fuller, Mike Wong, and Greg Sharp (for extensive
testing and improvement of the Kayenta model and its implementation in
several host codes). The majority of this research was performed at
Sandia National Laboratories and the Army Research Laboratory, with some
additional support from Schlumberger corporation. Sandia National
Laboratories is a multi-program laboratory managed and operated by
Sandia Corporation, a wholly owned subsidiary of Lockheed Martin
Corporation, for the US Department of Energy's National Nuclear Security
Administration under contract DE-AC04-94AL85000. SAND2014-0865J.
NR 89
TC 2
Z9 2
U1 2
U2 13
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0029-5981
EI 1097-0207
J9 INT J NUMER METH ENG
JI Int. J. Numer. Methods Eng.
PD APR 20
PY 2015
VL 102
IS 3-4
SI SI
BP 468
EP 495
DI 10.1002/nme.4699
PG 28
WC Engineering, Multidisciplinary; Mathematics, Interdisciplinary
Applications
SC Engineering; Mathematics
GA CF6BZ
UT WOS:000352642900014
ER
PT J
AU Kibuuka, H
Berkowitz, NM
Millard, M
Enama, ME
Tindikahwa, A
Sekiziyivu, AB
Costner, P
Sitar, S
Glover, D
Hu, ZH
Joshi, G
Stanley, D
Kunchai, M
Eller, LA
Bailer, RT
Koup, RA
Nabel, GJ
Mascola, JR
Sullivan, NJ
Graham, BS
Roederer, M
Michael, NL
Robb, ML
Ledgerwood, JE
AF Kibuuka, Hannah
Berkowitz, Nina M.
Millard, Monica
Enama, Mary E.
Tindikahwa, Allan
Sekiziyivu, Arthur B.
Costner, Pamela
Sitar, Sandra
Glover, Deline
Hu, Zonghui
Joshi, Gyan
Stanley, Daphne
Kunchai, Meghan
Eller, Leigh Anne
Bailer, Robert T.
Koup, Richard A.
Nabel, Gary J.
Mascola, John R.
Sullivan, Nancy J.
Graham, Barney S.
Roederer, Mario
Michael, Nelson L.
Robb, Merlin L.
Ledgerwood, Julie E.
CA RV 247 Study Team
TI Safety and immunogenicity of Ebola virus and Marburg virus glycoprotein
DNA vaccines assessed separately and concomitantly in healthy Ugandan
adults: a phase 1b, randomised, double-blind, placebo-controlled
clinical trial
SO LANCET
LA English
DT Article
ID NONHUMAN-PRIMATES; NEUTROPENIA; VACCINATION; INFECTION; FEVER
AB Background Ebola virus and Marburg virus cause serious disease outbreaks with high case fatality rates. We aimed to assess the safety and immunogenicity of two investigational DNA vaccines, one (EBO vaccine) encoding Ebola virus Zaire and Sudan glycoproteins and one (MAR) encoding Marburg virus glycoprotein.
Methods RV 247 was a phase 1b, double-blinded, randomised, placebo-controlled clinical trial in Kampala, Uganda to examine the safety and immunogenicity of the EBO and MAR vaccines given individually and concomitantly. Healthy adult volunteers aged 18-50 years were randomly assigned (5: 1) to receive three injections of vaccine or placebo at weeks 0, 4, and 8, with vaccine allocations divided equally between three active vaccine groups: EBO vaccine only, MAR vaccine only, and both vaccines. The primary study objective was to investigate the safety and tolerability of the vaccines, as assessed by local and systemic reactogenicity and adverse events. We also assessed immunogenicity on the basis of antibody responses (ELISA) and T-cell responses (ELISpot and intracellular cytokine staining assays) 4 weeks after the third injection. Participants and investigators were masked to group assignment. Analysis was based on the intention-to-treat principle. This trial is registered at ClinicalTrials.gov, number NCT00997607.
Findings 108 participants were enrolled into the study between Nov 2, 2009, and April 15, 2010. All 108 participants received at least one study injection (including 100 who completed the injection schedule) and were included in safety and tolerability analyses; 107 for whom data were available were included in the immunogenicity analyses. Study injections were well tolerated, with no significant differences in local or systemic reactions between groups. The vaccines elicited antibody and T-cell responses specific to the glycoproteins received and we detected no differences between the separate and concomitant use of the two vaccines. 17 of 30 (57%, 95% CI 37-75) participants in the EBO vaccine group had an antibody response to the Ebola Zaire glycoprotein, as did 14 of 30 (47%, 28-66) in the group that received both vaccines. 15 of 30 (50%, 31-69) participants in the EBO vaccine group had an antibody response to the Ebola Sudan glycoprotein, as did 15 of 30 (50%, 31-69) in the group that received both vaccines. Nine of 29 (31%, 15-51) participants in the MAR vaccine groups had an antibody response to the Marburg glycoprotein, as did seven of 30 (23%, 10-42) in the group that received both vaccines. 19 of 30 (63%, 44-80) participants in the EBO vaccine group had a T-cell response to the Ebola Zaire glycoprotein, as did 10 of 30 (33%, 17-53) in the group that received both vaccines. 13 of 30 (43%, 25-63) participants in the EBO vaccine group had a T-cell response to the Ebola Sudan glycoprotein, as did 10 of 30 (33%, 17-53) in the group that received both vaccines. 15 of 29 (52%, 33-71) participants in the MAR vaccine group had a T-cell response to the Marburg glycoprotein, as did 13 of 30 (43%, 25-63) in the group that received both vaccines.
Interpretation This study is the first Ebola or Marburg vaccine trial done in Africa, and the results show that, given separately or together, both vaccines were well tolerated and elicited antigen-specific humoral and cellular immune responses. These findings have contributed to the accelerated development of more potent Ebola virus vaccines that encode the same wild-type glycoprotein antigens as the EBO vaccine, which are being assessed during the 2014 Ebola virus disease outbreak in west Africa.
C1 [Kibuuka, Hannah; Millard, Monica; Tindikahwa, Allan; Sekiziyivu, Arthur B.] Makerere Univ, Walter Reed Project, Kampala, Uganda.
[Berkowitz, Nina M.; Enama, Mary E.; Costner, Pamela; Sitar, Sandra; Stanley, Daphne; Bailer, Robert T.; Koup, Richard A.; Nabel, Gary J.; Mascola, John R.; Sullivan, Nancy J.; Graham, Barney S.; Roederer, Mario; Ledgerwood, Julie E.] NIAID, Vaccine Res Ctr, NIH, Bethesda, MD 20892 USA.
[Hu, Zonghui] NIAID, Biostat Res Branch, Div Clin Res, NIH, Bethesda, MD 20892 USA.
[Glover, Deline; Eller, Leigh Anne; Michael, Nelson L.; Robb, Merlin L.] US Mil HIV Res Program, Bethesda, MD USA.
[Joshi, Gyan] Frederick Natl Lab Canc Res, Clin Monitoring Res Program, Leidos Biomed Res, Frederick, MD USA.
[Kunchai, Meghan] EMMES Corp, Rockville, MD USA.
[Nabel, Gary J.] Sanofi, Cambridge, MA USA.
[Michael, Nelson L.] Walter Reed Army Inst Res, Silver Spring, MD USA.
RP Ledgerwood, JE (reprint author), NIAID, Vaccine Res Ctr, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA.
EM Ledgerwood@mail.nih.gov
FU US Department of Defense Infectious Disease Clinical Research Program;
US National Institutes of Health Intramural Research Program
FX US Department of Defense Infectious Disease Clinical Research Program
and US National Institutes of Health Intramural Research Program.
NR 33
TC 22
Z9 24
U1 2
U2 25
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0140-6736
EI 1474-547X
J9 LANCET
JI Lancet
PD APR 18
PY 2015
VL 385
IS 9977
BP 1545
EP 1554
DI 10.1016/S0140-6736(14)62385-0
PG 10
WC Medicine, General & Internal
SC General & Internal Medicine
GA CG3ZT
UT WOS:000353220000036
PM 25540891
ER
PT J
AU West, BJ
Turalska, M
Grigolini, P
AF West, B. J.
Turalska, M.
Grigolini, Paolo
TI Fractional calculus ties the microscopic and macroscopic scales of
complex network dynamics
SO NEW JOURNAL OF PHYSICS
LA English
DT Article
DE complex networks; fractional calculus; decision making
ID TRANSITIONS; STATISTICS
AB A two-state, master equation-based decision-making model has been shown to generate phase transitions, to be topologically complex, and to manifest temporal complexity through an inverse power-law probability distribution function in the switching times between the two critical states of consensus. These properties are entailed by the fundamental assumption that the network elements in the decision-making model imperfectly imitate one another. The process of subordination establishes that a single network element can be described by a fractional master equation whose analytic solution yields the observed inverse power-law probability distribution obtained by numerical integration of the two-state master equation to a high degree of accuracy.
C1 [West, B. J.; Turalska, M.] Duke Univ, Dept Phys, Durham, NC 27709 USA.
[West, B. J.] US Army, Res Off, Informat Sci Directorate, Res Triangle Pk, NC 27708 USA.
[Grigolini, Paolo] Univ N Texas, Ctr Nonlinear Sci, Denton, TX 76203 USA.
RP West, BJ (reprint author), Duke Univ, Dept Phys, Durham, NC 27709 USA.
EM bruce.j.west.civ@mail.mil; mat51@phy.duke.edu; grigo@unt.edu
FU US Army Research Office; ARO [W911NF-11-1-0478, W911NF-04-D-0001]; Welch
Foundation [B-1577]
FX The authors would like to thank the US Army Research Office for
supporting this research. P.G. warmly thanks the ARO and the Welch
Foundation for their support through Grants No. W911NF-11-1-0478 and No.
B-1577, respectively. MT thanks the ARO for their support through Grant
No. W911NF-04-D-0001.
NR 35
TC 4
Z9 4
U1 1
U2 9
PU IOP PUBLISHING LTD
PI BRISTOL
PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND
SN 1367-2630
J9 NEW J PHYS
JI New J. Phys.
PD APR 17
PY 2015
VL 17
AR 045009
DI 10.1088/1367-2630/17/4/045009
PG 13
WC Physics, Multidisciplinary
SC Physics
GA CH4SL
UT WOS:000354023100001
ER
PT J
AU Kaplan, JE
Hamm, TE
Forhan, S
Hassani, AS
Bang, G
Weyant, E
Tchuenche, M
Langley, C
Lapidos-Salaiz, I
Bateganya, MH
AF Kaplan, Jonathan E.
Hamm, Tiffany E.
Forhan, Sara
Hassani, Ahmed Saadani
Bang, Gail
Weyant, Emily
Tchuenche, Michel
Langley, Carol
Lapidos-Salaiz, Ilana
Bateganya, Moses H.
TI The Impact of HIV Care and Support Interventions on Key Outcomes in Low-
and Middle-Income Countries: A Literature Review-Introduction
SO JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES
LA English
DT Article
C1 [Kaplan, Jonathan E.; Forhan, Sara; Hassani, Ahmed Saadani; Tchuenche, Michel; Bateganya, Moses H.] Ctr Dis Control & Prevent, Div Global HIV AIDS, Ctr Global Hlth, Atlanta, GA 30333 USA.
[Hamm, Tiffany E.] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD USA.
[Hamm, Tiffany E.] Henry M Jackson Fdn Adv Mil Med, Bethesda, MD USA.
[Bang, Gail; Weyant, Emily] CDC, Div Epidemiol Anal & Lib Serv, Ctr Surveillance Epidemiol & Lab Serv, Atlanta, GA 30333 USA.
[Langley, Carol] US Dept State, Off US Global AIDS Coordinator & Hlth Diplomacy, Washington, DC 20520 USA.
[Lapidos-Salaiz, Ilana] US Agcy Int Dev, Washington, DC 20523 USA.
RP Kaplan, JE (reprint author), Ctr Dis Control & Prevent, Div Global HIV AIDS, Mailstop E-04,1600 Clifton Rd NE, Atlanta, GA 30333 USA.
EM jxk2@cdc.gov
FU US President's Emergency Plan for AIDS Relief (PEPFAR) through the US
Department of State, Office of the US Global AIDS Coordinator and Health
Diplomacy; US Centers for Disease Control and Prevention; US Agency for
International Development; Henry M. Jackson Foundation for the
Advancement of Military Medicine, Inc. [W81XWH-07-2-0067]; US Department
of Defense [W81XWH-07-2-0067]
FX Supported by the US President's Emergency Plan for AIDS Relief (PEPFAR)
through the US Department of State, Office of the US Global AIDS
Coordinator and Health Diplomacy, the US Centers for Disease Control and
Prevention, and the US Agency for International Development, and also
supported through a cooperative agreement (W81XWH-07-2-0067) between The
Henry M. Jackson Foundation for the Advancement of Military Medicine,
Inc. and the US Department of Defense.
NR 7
TC 13
Z9 13
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1525-4135
EI 1077-9450
J9 JAIDS-J ACQ IMM DEF
JI JAIDS
PD APR 15
PY 2015
VL 68
SU 3
BP S253
EP S256
DI 10.1097/QAI.0000000000000495
PG 4
WC Immunology; Infectious Diseases
SC Immunology; Infectious Diseases
GA CH6CN
UT WOS:000354123500001
PM 25768864
ER
PT J
AU Langley, CL
Lapidos-Salaiz, I
Hamm, TE
Bateganya, MH
Firth, J
Wilson, M
Martin, J
Dierberg, K
AF Langley, Carol L.
Lapidos-Salaiz, Ilana
Hamm, Tiffany E.
Bateganya, Moses H.
Firth, Jacqueline
Wilson, Melinda
Martin, Julia
Dierberg, Kerry
TI Prioritizing HIV Care and Support Interventions-Moving From Evidence to
Policy
SO JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES
LA English
DT Article
DE HIV; care; support; policy; LMIC
C1 [Langley, Carol L.; Martin, Julia; Dierberg, Kerry] US Dept State, Off US Global AIDS Coordinator & Hlth Diplomacy S, Washington, DC 20522 USA.
[Lapidos-Salaiz, Ilana; Firth, Jacqueline; Wilson, Melinda] US Agcy Int Dev, Off HIV AIDS, Washington, DC 20523 USA.
[Hamm, Tiffany E.] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD USA.
[Hamm, Tiffany E.] Henry M Jackson Fdn Adv Mil Med, Bethesda, MD USA.
[Bateganya, Moses H.] Ctr Dis Control & Prevent CDC, Div Global HIV AIDS, Ctr Global Hlth, Atlanta, GA USA.
RP Langley, CL (reprint author), US Dept State, Off US Global AIDS Coordinator & Hlth Diplomacy S, SA-22,Room 10300, Washington, DC 20522 USA.
EM langleycl@state.gov
FU US President's Emergency Plan for AIDS Relief (PEPFAR) through the
United States Department of State, Office of the US Global AIDS
Coordinator and Health Diplomacy; US Centers for Disease Control; US
Agency for International Development; Henry M. Jackson Foundation for
the Advancement of Military Medicine, Inc. [W81XWH-07-2-0067]; US
Department of Defense [W81XWH-07-2-0067]
FX Supported by the US President's Emergency Plan for AIDS Relief (PEPFAR)
through the United States Department of State, Office of the US Global
AIDS Coordinator and Health Diplomacy, the US Centers for Disease
Control, and the US Agency for International Development as well as
supported through a cooperative agreement (W81XWH-07-2-0067) between The
Henry M. Jackson Foundation for the Advancement of Military Medicine,
Inc. and the US Department of Defense.
NR 5
TC 1
Z9 1
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1525-4135
EI 1077-9450
J9 JAIDS-J ACQ IMM DEF
JI JAIDS
PD APR 15
PY 2015
VL 68
SU 3
BP S375
EP S378
DI 10.1097/QAI.0000000000000545
PG 4
WC Immunology; Infectious Diseases
SC Immunology; Infectious Diseases
GA CH6CN
UT WOS:000354123500014
PM 25768877
ER
PT J
AU Stabinski, L
O'Connor, S
Barnhart, M
Kahn, RJ
Hamm, TE
AF Stabinski, Lara
O'Connor, Siobhan
Barnhart, Matthew
Kahn, Rebecca J.
Hamm, Tiffany E.
TI Prevalence of HIV and Hepatitis B Virus Co-Infection in Sub-Saharan
Africa and the Potential Impact and Program Feasibility of Hepatitis B
Surface Antigen Screening in Resource-Limited Settings
SO JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES
LA English
DT Article
DE hepatitis B virus; resource-limited setting; hepatitis B surface
antigen; rapid strip assay; HIV; HBV co-infection
ID HUMAN-IMMUNODEFICIENCY-VIRUS; RECEIVING ANTIRETROVIRAL THERAPY; CAMILLE
MEDICAL-CENTER; C VIRAL COINFECTIONS; DAR-ES-SALAAM; INFECTED PATIENTS;
SOUTH-AFRICA; PREGNANT-WOMEN; BURKINA-FASO; POSITIVE PATIENTS
AB Background:Screening people living with HIV for hepatitis B virus (HBV) co-infection is recommended in resource-rich settings to optimize HIV antiretroviral therapy (ART) and mitigate HBV-related liver disease. This review examines the need, feasibility, and impact of screening for HBV in resource-limited settings (RLS).Methods:We searched 6 databases to identify peer-reviewed publications between 2007 and 2013 addressing (1) HIV/HBV co-infection frequency in sub-Saharan Africa (SSA); (2) performance of hepatitis B surface antigen (HBsAg) rapid strip assays (RSAs) in RLS; (3) impact of HBV co-infection on morbidity, mortality, or liver disease progression; and/or (4) impact of HBV-suppressive antiretroviral medications as part of ART on at least one of 5 outcomes (mortality, morbidity, HIV transmission, retention in HIV care, or quality of life). We rated the quality of individual articles and summarized the body of evidence and expected impact of each intervention per outcome addressed.Results:Of 3940 identified studies, 85 were included in the review: 55 addressed HIV/HBV co-infection frequency; 6 described HBsAg RSA performance; and 24 addressed the impact of HIV/HBV co-infection and ART. HIV/HBV frequency in sub-Saharan Africa varied from 0% to >28.4%. RSA performance in RLS showed good, although variable, sensitivity and specificity. Quality of studies ranged from strong to weak. Overall quality of evidence for the impact of HIV/HBV co-infection and ART on morbidity and mortality was fair and good to fair, respectively.Conclusions:Combined, the body of evidence reviewed suggests that HBsAg screening among people living with HIV could have substantial impact on preventing morbidity and mortality among HIV/HBV co-infected individuals in RLS.
C1 [Stabinski, Lara; Kahn, Rebecca J.] US Dept State, Off US Global AIDS Coordinator & Hlth Diplomacy, Washington, DC 20006 USA.
[O'Connor, Siobhan] US Ctr Dis Control & Prevent, Div Viral Hepatitis, Natl Ctr HIV AIDS STD & TB Prevent, Atlanta, GA USA.
[Barnhart, Matthew] US Agcy Int Dev, Off HIV & AIDS, Bur Global Hlth, Washington, DC 20523 USA.
[Hamm, Tiffany E.] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD USA.
[Hamm, Tiffany E.] Henry M Jackson Fdn Adv Mil Med Inc, Bethesda, MD USA.
RP Stabinski, L (reprint author), US Dept State, Off US Global AIDS Coordinator & Hlth Diplomacy, 1800 G St NW,SA-22, Washington, DC 20006 USA.
EM stabinskill@state.gov
FU US President's Emergency Plan for AIDS Relief (PEPFAR) through the
United States Department of State, Office of the US Global AIDS
Coordinator and Health Diplomacy; US Agency for International
Development; US Centers for Disease Control and Prevention; Henry M.
Jackson Foundation for the Advancement of Military Medicine, Inc.
[W81XWH-07-2-0067]; US Department of Defense [W81XWH-07-2-0067]
FX Supported by the US President's Emergency Plan for AIDS Relief (PEPFAR)
through the United States Department of State, Office of the US Global
AIDS Coordinator and Health Diplomacy, the US Agency for International
Development, the US Centers for Disease Control and Prevention, as well
as supported through a cooperative agreement (W81XWH-07-2-0067) between
the Henry M. Jackson Foundation for the Advancement of Military
Medicine, Inc. and the US Department of Defense.
NR 98
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U1 0
U2 6
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1525-4135
EI 1077-9450
J9 JAIDS-J ACQ IMM DEF
JI JAIDS
PD APR 15
PY 2015
VL 68
SU 3
BP S274
EP S285
DI 10.1097/QAI.0000000000000496
PG 12
WC Immunology; Infectious Diseases
SC Immunology; Infectious Diseases
GA CH6CN
UT WOS:000354123500004
PM 25768867
ER
PT J
AU Miller, SL
Aroniadou-Anderjaska, V
Figueiredo, TH
Prager, EM
Almeida-Suhett, CP
Apland, JP
Braga, MFM
AF Miller, Steven L.
Aroniadou-Anderjaska, Vassiliki
Figueiredo, Taiza H.
Prager, Eric M.
Almeida-Suhett, Camila P.
Apland, James P.
Braga, Maria F. M.
TI A rat model of nerve agent exposure applicable to the pediatric
population: The anticonvulsant efficacies of atropine and GluK1
antagonists
SO TOXICOLOGY AND APPLIED PHARMACOLOGY
LA English
DT Article
DE Immature rats; Soman; Seizures; Acetylcholinesterase; Atropine sulfate;
GluK1 antagonists
ID KAINATE RECEPTOR ANTAGONIST; TEMPORAL-LOBE EPILEPSY; BASOLATERAL
AMYGDALA; INDUCED SEIZURES; STATUS EPILEPTICUS; DEVELOPING BRAIN;
IMMATURE BRAIN; ACETYLCHOLINESTERASE ACTIVITY; DEVELOPMENTAL-CHANGES;
SOMAN-EXPOSURE
AB Inhibition of acetylcholinesterase (AChE) after nerve agent exposure induces status epilepticus (SE), which causes brain damage or death. The development of countermeasures appropriate for the pediatric population requires testing of anticonvulsant treatments in immature animals. In the present study, exposure of 21-day-old (P21) rats to different doses of soman, followed by probit analysis, produced an LD50 of 62 mu g/kg. The onset of behaviorally-observed SE was accompanied by a dramatic decrease in brain AChE activity; rats who did not develop SE had significantly less reduction of AChE activity in the basolateral amygdala than rats who developed SE. Atropine sulfate (ATS) at 2 mg/kg, administered 20 min after soman exposure (1.2 x LD50), terminated seizures. ATS at 0.5 mg/kg, given along with an oxime within 1 min after exposure, allowed testing of anticonvulsants at delayed time-points. The AMPA/GluK1 receptor antagonist LY293558, or the specific GluK1 antagonist UBP302, administered 1 h post-exposure, terminated SE. There were no degenerating neurons in soman-exposed P21 rats, but both the amygdala and the hippocampus were smaller than in control rats at 30 and 90 days post-exposure; this pathology was not present in rats treated with LY293558. Behavioral deficits present at 30 days post-exposure, were also prevented by LY293558 treatment. Thus, in immature animals, a single injection of atropine is sufficient to halt nerve agent-induced seizures, if administered timely. Testing anticonvulsants at delayed time-points requires early administration of ATS at a low dose, sufficient to counteract only peripheral toxicity. LY293558 administered 1 h post-exposure, prevents brain pathology and behavioral deficits. Published by Elsevier Inc.
C1 [Miller, Steven L.; Aroniadou-Anderjaska, Vassiliki; Figueiredo, Taiza H.; Prager, Eric M.; Almeida-Suhett, Camila P.; Braga, Maria F. M.] Uniformed Serv Univ Hlth Sci, Dept Anat Physiol & Genet, Bethesda, MD 20814 USA.
[Aroniadou-Anderjaska, Vassiliki; Braga, Maria F. M.] Uniformed Serv Univ Hlth Sci, Dept Psychiat, Bethesda, MD 20814 USA.
[Miller, Steven L.; Aroniadou-Anderjaska, Vassiliki; Prager, Eric M.; Almeida-Suhett, Camila P.; Braga, Maria F. M.] Uniformed Serv Univ Hlth Sci, Program Neurosci, Bethesda, MD 20814 USA.
[Apland, James P.] US Army, Med Res Inst Chem Def, Neurotoxicol Branch, Aberdeen Proving Ground, MD 21010 USA.
RP Braga, MFM (reprint author), Uniformed Serv Univ Hlth Sci, F Edward Hebert Sch Med, Dept Anat Physiol & Genet, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA.
EM stevenmiller17@gmail.com; vanderjaska@usuhs.edu;
taiza.figueiredo.ctr@usuhs.edu; eric.prager683@gmail.com;
camilapalmeida@gmail.com; james.p.apland.civ@mail.mil;
maria.braga@usuhs.edu
RI Prager, Eric/O-1567-2015;
OI Prager, Eric/0000-0002-3810-0985; Miller, Steven/0000-0002-2061-8188
FU CounterACT Program, National Institutes of Health, Office of the
Director; National Institute of Neurologic Disorders and Stroke
[5U01NS058162-07]
FX We thank Dr. Cara H. Olsen for her expert advice on the procedure for
the estimation of LD50. This work was supported by the
CounterACT Program, National Institutes of Health, Office of the
Director and the National Institute of Neurologic Disorders and Stroke
[Grant Number 5U01NS058162-07].
NR 91
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U2 16
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0041-008X
EI 1096-0333
J9 TOXICOL APPL PHARM
JI Toxicol. Appl. Pharmacol.
PD APR 15
PY 2015
VL 284
IS 2
BP 204
EP 216
DI 10.1016/j.taap.2015.02.008
PG 13
WC Pharmacology & Pharmacy; Toxicology
SC Pharmacology & Pharmacy; Toxicology
GA CH2OH
UT WOS:000353864000011
PM 25689173
ER
PT J
AU Akers, KS
Rowan, MP
Niece, KL
Graybill, JC
Mende, K
Chung, KK
Murray, CK
AF Akers, Kevin S.
Rowan, Matthew P.
Niece, Krista L.
Graybill, John C.
Mende, Katrin
Chung, Kevin K.
Murray, Clinton K.
TI Antifungal wound penetration of amphotericin and voriconazole in
combat-related injuries: case report
SO BMC INFECTIOUS DISEASES
LA English
DT Article
DE Invasive fungal infection; Pharmacokinetics; Negative-Pressure Wound
Therapy; NPWT; Effluent
ID INVASIVE FUNGAL-INFECTIONS; B DEOXYCHOLATE; EXPRESSION; PLASMA;
PHARMACOKINETICS; EPIDEMIOLOGY; BATTLEFIELD; BIOMARKERS; CYTOKINE;
REGIMENS
AB Background: Survivors of combat trauma can have long and challenging recoveries, which may be complicated by infection. Invasive fungal infections are a rare but serious complication with limited treatment options. Currently, aggressive surgical debridement is the standard of care, with antifungal agents used adjunctively with uncertain efficacy. Anecdotal evidence suggests that antifungal agents may be ineffective in the absence of surgical debridement, and studies have yet to correlate antifungal concentrations in plasma and wounds.
Case presentation: Here we report the systemic pharmacokinetics and wound effluent antifungal concentrations of five wounds from two male patients, aged 28 and 30 years old who sustained combat-related blast injuries in southern Afghanistan, with proven or possible invasive fungal infection. Our data demonstrate that while voriconazole sufficiently penetrated the wound resulting in detectable effluent levels, free amphotericin B (unbound to plasma) was not present in wound effluent despite sufficient concentrations in circulating plasma. In addition, considerable between-patient and within-patient variability was observed in antifungal pharmacokinetic parameters.
Conclusion: These data highlight the need for further studies evaluating wound penetration of commonly used antifungals and the role for therapeutic drug monitoring in providing optimal care for critically ill and injured war fighters.
C1 [Akers, Kevin S.; Rowan, Matthew P.; Niece, Krista L.; Graybill, John C.; Chung, Kevin K.] US Army, Inst Surg Res, Ft Sam Houston, TX 78234 USA.
[Akers, Kevin S.; Mende, Katrin; Murray, Clinton K.] San Antonio Mil Med Ctr, Dept Med, Infect Dis Serv, Ft Sam Houston, TX 78234 USA.
[Mende, Katrin] Uniformed Serv Univ Hlth Sci, Infect Dis Clin Res Program, Bethesda, MD 20814 USA.
[Chung, Kevin K.; Murray, Clinton K.] Uniformed Serv Univ Hlth Sci, Dept Med, Bethesda, MD 20814 USA.
RP Akers, KS (reprint author), US Army, Inst Surg Res, 3698 Chambers Pass,JBSA, Ft Sam Houston, TX 78234 USA.
EM kevin.s.akers.mil@mail.mil
FU Defense Medical Research & Development Program (DMRDP) Military
Infectious Disease Clinical Trial Award (MID-CTA)
[D_MIDCTA_I_12_J2_299]; U.S. Department of Energy; USAMRMC
FX This study was conducted under a protocol reviewed and approved by the
U.S. Army Medical Research and Materiel Command Institutional Review
Board and in accordance with approved protocols BAMC C.2013.095 and
H-09-059. This work was supported by Defense Medical Research &
Development Program (DMRDP) Military Infectious Disease Clinical Trial
Award (MID-CTA) #D_MIDCTA_I_12_J2_299, and in part by an appointment to
the Postgraduate Research Participation Program at the U.S. Army
Institute of Surgical Research administered by the Oak Ridge Institute
for Science and Education through an interagency agreement between the
U.S. Department of Energy and USAMRMC. A portion of this material was
presented at the 2014 Military Health Systems Research Symposium, Ft.
Lauderdale FL. We gratefully acknowledge the invaluable contributions of
Doug Johnson LVN, Kristie Harnisch RN, Crystal Rosemann RN, Charnae
Williams BS, and the participating research subjects, without whom this
research would not be possible.
NR 32
TC 2
Z9 2
U1 1
U2 2
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1471-2334
J9 BMC INFECT DIS
JI BMC Infect. Dis.
PD APR 15
PY 2015
VL 15
AR 184
DI 10.1186/s12879-015-0918-8
PG 7
WC Infectious Diseases
SC Infectious Diseases
GA CG3PN
UT WOS:000353192200001
PM 25886578
ER
PT J
AU Tachibana, M
Suwanabun, N
Kaneko, O
Iriko, H
Otsuki, H
Sattabongkot, J
Kaneko, A
Herrera, S
Torii, M
Tsuboi, T
AF Tachibana, Mayumi
Suwanabun, Nantavadee
Kaneko, Osamu
Iriko, Hideyuki
Otsuki, Hitoshi
Sattabongkot, Jetsumon
Kaneko, Akira
Herrera, Socrates
Torii, Motomi
Tsuboi, Takafumi
TI Plasmodium vivax gametocyte proteins, Pvs48/45 and Pvs47, induce
transmission-reducing antibodies by DNA immunization
SO VACCINE
LA English
DT Article
DE DNA vaccine; Gametocyte; Malaria; Plasmodium vivax; Polymorphism;
Transmission-blocking vaccine
ID BLOCKING VACCINE CANDIDATES; SURFACE PROTEIN; SEQUENCE POLYMORPHISMS;
TARGET ANTIGENS; HUMAN MALARIA; SEXUAL STAGE; FALCIPARUM; PFS48/45;
PVS25; IMMUNITY
AB Malaria transmission-blocking vaccines (TBV) aim to interfere with the development of the malaria parasite in the mosquito vector, and thus prevent spread of transmission in a community. To date three TBV candidates have been identified in Plasmodium vivax; namely, the gametocyte/gamete protein Pvs230, and the ookinete surface proteins Pvs25 and Pvs28. The Plasmodium falciparum gametocyte/gamete stage proteins Pfs48/45 and Pfs47 have been studied as TBV candidates, and Pfs48/45 shown to induce transmission-blocking antibodies, but the candidacy of their orthologs in P. vivax, Pvs48/45 (PVX_083235) and Pvs47 (PVX_083240), for vivax TBV have not been tested. Herein we investigated whether targeting Pvs48/45 and Pvs47 can inhibit parasite transmission to mosquitoes, using P. vivax isolates obtained in Thailand. Mouse antisera directed against the products from plasmids expressing Pvs48/45 and Pvs47 detected proteins of approximately 45- and 40-kDa, respectively, in the P. vivax gametocyte lysate, by Western blot analysis under non-reducing conditions. In immunofluorescence assays Pvs48/45 was detected predominantly on the surface and Pvs47 was detected in the cytoplasm of gametocytes. Membrane feeding transmission assays demonstrated that anti-Pvs48/45 and -Pvs47 mouse sera significantly reduced the number of P. vivax oocysts developing in the mosquito midgut. Limited amino acid polymorphism of these proteins was observed among 27 P. vivax isolates obtained from Thailand, Vanuatu, and Colombia; suggesting that polymorphism may not be an impediment for the utilization of Pvs48/45 and Pvs47 as TBV antigens. In one Thai isolate we found that the fourth cysteine residue in the Pvs47 cysteine-rich domain (CRD) III (amino acid position 337) is substituted to phenylalanine. However, antibodies targeting Pvs47 CRDI-Ill showed a significant transmission-reducing activity against this isolate, suggesting that this substitution in Pvs47 was not critical for recognition by the generated antibodies. In conclusion, our results indicate that Pvs48/45 and Pvs47 are potential transmission-blocking vaccine candidates of P. vivax. (C) 2015 Elsevier Ltd. All rights reserved.
C1 [Tachibana, Mayumi; Torii, Motomi] Ehime Univ, Proteosci Ctr, Div Mol Parasitol, Toon, Ehime 7910295, Japan.
[Suwanabun, Nantavadee; Sattabongkot, Jetsumon] Armed Forces Res Inst Med Sci, Dept Entomol, Bangkok 10400, Thailand.
[Kaneko, Osamu] Nagasaki Univ, Inst Trop Med NEKKEN, Dept Protozool, Nagasaki 8528523, Japan.
[Iriko, Hideyuki] Kobe Univ, Grad Sch Hlth Sci, Fac Hlth Sci, Dept Parasitol, Kobe, Hyogo 6540142, Japan.
[Otsuki, Hitoshi] Tottori Univ, Div Med Zool, Fac Med, Yonago, Tottori 6838503, Japan.
[Kaneko, Akira] Osaka City Univ, Grad Sch Med, Dept Parasitol, Osaka 5458585, Japan.
[Kaneko, Akira] Karolinska Inst, Dept Microbiol Tumor & Cell Biol, Isl Malaria Grp, SE-17777 Stockholm, Sweden.
[Herrera, Socrates] Malaria Vaccine & Drug Dev Ctr, Cali 25574, Colombia.
[Tsuboi, Takafumi] Ehime Univ, Div Malaria Res, Proteosci Ctr, Matsuyama, Ehime 7908577, Japan.
RP Tsuboi, T (reprint author), Ehime Univ, Div Malaria Res, Proteosci Ctr, Matsuyama, Ehime 7908577, Japan.
EM torii@m.ehime-u.ac.jp; tsuboi.takafumi.mb@ehime-u.ac.jp
FU MEXT KAKENHI [23117008]; JSPS KAKENHI, Japan [26253026, 26670202]; US
NIAID [U19AI089702]
FX We thank the late Prof. Kazuyuki Tanabe, Laboratory of Malariology,
Research Institute for Microbial Diseases, Osaka University, Osaka,
Japan for helpful discussion and comments on the manuscript. We also
thank the staff of the Department of Entomology, Armed Forces Research
Institute of Medical Sciences, Bangkok, Thailand, for their technical
assistance, and Prof. Thomas J. Templeton for the critical reading of
the manuscript. We also thank Vical Inc. for providing the VR1020 DNA
vaccine plasmid and Vaxfectin (R) adjuvant. TT was supported in part by
MEXT KAKENHI (23117008) and JSPS KAKENHI (26253026, 26670202), Japan. SH
was supported by grant US NIAID U19AI089702.
NR 51
TC 7
Z9 8
U1 1
U2 21
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0264-410X
EI 1873-2518
J9 VACCINE
JI Vaccine
PD APR 15
PY 2015
VL 33
IS 16
BP 1901
EP 1908
DI 10.1016/j.vaccine.2015.03.008
PG 8
WC Immunology; Medicine, Research & Experimental
SC Immunology; Research & Experimental Medicine
GA CF6JC
UT WOS:000352662000002
PM 25765968
ER
PT J
AU Guo, JJ
Reddy, KM
Hirata, A
Fujita, T
Gazonas, GA
McCauley, JW
Chen, MW
AF Guo, J. J.
Reddy, K. Madhav
Hirata, A.
Fujita, T.
Gazonas, G. A.
McCauley, J. W.
Chen, M. W.
TI Sample size induced brittle-to-ductile transition of single-crystal
aluminum nitride
SO ACTA MATERIALIA
LA English
DT Article
DE Ceramics; Micropillar; Plastic deformation; Size effect; Transmission
electron microscopy
ID ROOM-TEMPERATURE; MECHANICAL-PROPERTIES; PLASTIC-DEFORMATION;
MICROMETER-SCALE; BORON-CARBIDE; COMPRESSION; CERAMICS; FRACTURE;
STRENGTH; SILICON
AB Ceramics are known to be mechanically hard, chemically inert and electrically insulating for many important applications. However, they usually suffer from brittleness and have moderate strength that strongly depends on their microscopic structure. In this study, we report a size induced brittle-to-ductile transition in single-crystal aluminum nitride (MN). When the specimen diameters are smaller than similar to 3-4 mu m, AlN micropillars show metal-like plastic flow under room-temperature uniaxial compression. The unprecedented plastic strain of similar to 5-10% together with the ultrahigh strength of similar to 6.7 GPa has never been achieved before. Transmission electron microscopy demonstrates that dislocations play a dominant role in the plasticity of the micro-sized AlN. (c) 2015 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
C1 [Guo, J. J.; Reddy, K. Madhav; Hirata, A.; Fujita, T.; Chen, M. W.] Tohoku Univ, WPI Adv Inst Mat Res, Sendai, Miyagi 9808577, Japan.
[Gazonas, G. A.; McCauley, J. W.] US Army, Res Lab, Aberdeen Proving Ground, MD 21005 USA.
RP Chen, MW (reprint author), Tohoku Univ, WPI Adv Inst Mat Res, Sendai, Miyagi 9808577, Japan.
EM mwchen@wpi-aimr.tohoku.ac.jp
RI Fujita, Takeshi/B-1867-2009; Chen, Mingwei/A-4855-2010; Hirata,
Akihiko/A-4850-2010; guo, junjie/I-3189-2012;
OI Fujita, Takeshi/0000-0002-2318-0433; Chen, Mingwei/0000-0002-2850-8872;
guo, junjie/0000-0002-3414-3734; Gazonas, George/0000-0002-2715-016X
FU "World Premier International (WPI) Center Initiative for Atoms,
Molecules and Materials", MEXT, Japan; U.S. Army International
Technology Center Pacific (ITC-PAC) of Tokyo; U. S. Army Research Lab
through Johns Hopkins University
FX This work was supported by "World Premier International (WPI) Center
Initiative for Atoms, Molecules and Materials", MEXT, Japan; U.S. Army
International Technology Center Pacific (ITC-PAC) of Tokyo; and U. S.
Army Research Lab through Johns Hopkins University.
NR 44
TC 1
Z9 1
U1 6
U2 42
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 1359-6454
EI 1873-2453
J9 ACTA MATER
JI Acta Mater.
PD APR 15
PY 2015
VL 88
BP 252
EP 259
DI 10.1016/j.actamat.2015.01.043
PG 8
WC Materials Science, Multidisciplinary; Metallurgy & Metallurgical
Engineering
SC Materials Science; Metallurgy & Metallurgical Engineering
GA CE4KK
UT WOS:000351799300024
ER
PT J
AU Joachim, A
Nilsson, C
Aboud, S
Bakari, M
Lyamuya, EF
Robb, ML
Marovich, MA
Earl, P
Moss, B
Ochsenbauer, C
Wahren, B
Mhalu, F
Sandstrom, E
Biberfeld, G
Ferrari, G
Polonis, VR
AF Joachim, Agricola
Nilsson, Charlotta
Aboud, Said
Bakari, Muhammad
Lyamuya, Eligius F.
Robb, Merlin L.
Marovich, Mary A.
Earl, Patricia
Moss, Bernard
Ochsenbauer, Christina
Wahren, Britta
Mhalu, Fred
Sandstrom, Eric
Biberfeld, Gunnel
Ferrari, Guido
Polonis, Victoria R.
TI Potent Functional Antibody Responses Elicited by HIV-I DNA Priming and
Boosting with Heterologous HIV-1 Recombinant MVA in Healthy Tanzanian
Adults
SO PLOS ONE
LA English
DT Article
ID CELL-MEDIATED CYTOTOXICITY; NEUTRALIZING ANTIBODIES;
MONOCLONAL-ANTIBODIES; RHESUS MACAQUES; PROTECTIVE EFFICACY;
IMMUNE-RESPONSES; VACCINE; VIRUS; INFECTION; CHALLENGE
AB Vaccine-induced HIV antibodies were evaluated in serum samples collected from healthy Tanzanian volunteers participating in a phase I/II placebo-controlled double blind trial using multi-clade, multigene HIV-DNA priming and recombinant modified vaccinia Ankara (HIV-MVA) virus boosting (HIVIS03). The HIV-DNA vaccine contained plasmids expressing HIV-1 gp160 subtypes A, B, C, Rev B, Gag A, B and RTmut B, and the recombinant HIV-MVA boost expressed CRF01_AE HIV-1 Env subtype E and Gag-Pol subtype A. While no neutralizing antibodies were detected using pseudoviruses in the TZM-bl cell assay, this prime-boost vaccination induced neutralizing antibodies in 83% of HIVIS03 vaccinees when a peripheral blood mononuclear cell (PBMC) assay using luciferase reporter-infectious molecular clones (LucR-IMC) was employed. The serum neutralizing activity was significantly (but not completely) reduced upon depletion of natural killer (NK) cells from PBMC (p= 0.006), indicating a role for antibody-mediated Fcy-receptor function. High levels of antibody-dependent cellular cytotoxicity (ADCC)-mediating antibodies against CRF01_AE and/or subtype B were subsequently demonstrated in 97% of the sera of vaccinees. The magnitude of ADCC-mediating antibodies against CM235 CRF01_AE IMC-infected cells correlated with neutralizing antibodies against CM235 in the IMC/PBMC assay. In conclusion, HIV-DNA priming, followed by two HIV-MVA boosts elicited potent ADCC responses in a high proportion of Tanzanian vaccinees. Our findings highlight the potential of HIV-DNA prime HIV-MVA boost vaccines for induction of functional antibody responses and suggest this vaccine regimen and ADCC studies as potentially important new avenues in HIV vaccine development.
C1 [Joachim, Agricola; Aboud, Said; Lyamuya, Eligius F.; Mhalu, Fred] Muhimbili Univ Hlth & Allied Sci, Dept Microbiol & Immunol, Dar Es Salaam, Tanzania.
[Joachim, Agricola; Nilsson, Charlotta; Wahren, Britta; Biberfeld, Gunnel] Karolinska Inst, Dept Microbiol Tumor & Cell Biol, Stockholm, Sweden.
[Nilsson, Charlotta; Biberfeld, Gunnel] Publ Hlth Agcy Sweden, Solna, Sweden.
[Nilsson, Charlotta] Karolinska Inst, Dept Lab Med, Huddinge, Sweden.
[Bakari, Muhammad] Muhimbili Univ Hlth & Allied Sci, Dept Internal Med, Dar Es Salaam, Tanzania.
[Robb, Merlin L.] Henry M Jackson Fdn Adv Mil Med, Mil HIV Res Program, Bethesda, MD USA.
[Marovich, Mary A.; Polonis, Victoria R.] Walter Reed Army Inst Res, Mil HIV Res Program, Silver Spring, MD USA.
[Earl, Patricia; Moss, Bernard] NIAID, NIH, Bethesda, MD 20892 USA.
[Ochsenbauer, Christina] Univ Alabama Birmingham, Dept Med, Birmingham, AL 35294 USA.
[Sandstrom, Eric] Karolinska Inst Sodersjukhuset, Venhalsan, Stockholm, Sweden.
[Ferrari, Guido] Duke Univ, Med Ctr, Dept Surg, Durham, NC 27710 USA.
RP Joachim, A (reprint author), Muhimbili Univ Hlth & Allied Sci, Dept Microbiol & Immunol, Dar Es Salaam, Tanzania.
EM agricolaj@muhas.ac.tz
FU European Union; Swedish International Development Cooperation Agency
(Sida); Swedish Embassy Tanzania; European & Developing Countries
Clinical Trials Partnership (EDCTP) [CT.2006.33111.007]; Regional
HIV/AIDS Team for Africa, Embassy of Sweden, Lusaka [2150012801];
Collaboration for AIDS Vaccine Discovery (CAVD) grant from the Bill &
Melinda Gates Foundation [1032144]; Duke University Center for AIDS
Research (CFAR) [P30 AI64518]; US Military HIV Research program; Walter
Reed Army Institute of Research (WRAIR); Division of Intramural
Research, NIAD, NIH
FX This work was supported by the European Union, the Swedish International
Development Cooperation Agency (Sida),Swedish Embassy Tanzania, the
European & Developing Countries Clinical Trials Partnership (EDCTP,
project code CT.2006.33111.007), and The Regional HIV/AIDS Team for
Africa, Embassy of Sweden, Lusaka, jointly funded by Sweden and Norway
(Sida contribution number 2150012801). Additional support was provided
by the Collaboration for AIDS Vaccine Discovery (CAVD) grant from the
Bill & Melinda Gates Foundation (Grant ID: 1032144), Duke University
Center for AIDS Research (CFAR, grant P30 AI64518), the US Military HIV
Research program, Walter Reed Army Institute of Research (WRAIR) and the
Division of Intramural Research, NIAD, NIH. The funders had no role in
study design, data collection and analysis, decision to publish, or
preparation of the manuscript.
NR 40
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U1 1
U2 4
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD APR 14
PY 2015
VL 10
IS 4
AR e0118486
DI 10.1371/journal.pone.0118486
PG 15
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA CG1EB
UT WOS:000353014700001
PM 25874723
ER
PT J
AU Luk, TS
de Ceglia, D
Liu, S
Keeler, GA
Prasankumar, RP
Vincenti, MA
Scalora, M
Sinclair, MB
Campione, S
AF Luk, Ting S.
de Ceglia, Domenico
Liu, Sheng
Keeler, Gordon A.
Prasankumar, Rohit P.
Vincenti, Maria A.
Scalora, Michael
Sinclair, Michael B.
Campione, Salvatore
TI Enhanced third harmonic generation from the epsilon-near-zero modes of
ultrathin films
SO APPLIED PHYSICS LETTERS
LA English
DT Article
ID 2ND-HARMONIC GENERATION; SURFACE-PLASMONS; 3RD-HARMONIC GENERATION;
WAVE-GUIDES; THIN-FILMS; LIGHT; EMISSION; BOUNDARY; SILICON
AB We experimentally demonstrate efficient third harmonic generation from an indium tin oxide nanofilm (lambda/42 thick) on a glass substrate for a pump wavelength of 1.4 mu m. A conversion efficiency of 3.3 x 10(-6) is achieved by exploiting the field enhancement properties of the epsilon-near-zero mode with an enhancement factor of 200. This nanoscale frequency conversion method is applicable to other plasmonic materials and reststrahlen materials in proximity of the longitudinal optical phonon frequencies. (c) 2015 AIP Publishing LLC.
C1 [Luk, Ting S.; Liu, Sheng; Keeler, Gordon A.; Prasankumar, Rohit P.; Sinclair, Michael B.; Campione, Salvatore] Sandia Natl Labs, Albuquerque, NM 87185 USA.
[Luk, Ting S.; Liu, Sheng; Campione, Salvatore] Sandia Natl Labs, Ctr Integrated Nanotechnol CINT, Albuquerque, NM 87185 USA.
[de Ceglia, Domenico; Vincenti, Maria A.] Natl Res Council AMRDEC, Charles M Bowden Res Lab, Redstone Arsenal, AL 35898 USA.
[Prasankumar, Rohit P.] Los Alamos Natl Lab, Ctr Integrated Nanotechnol CINT LANL, Los Alamos, NM 87545 USA.
[Scalora, Michael] US Army RDECOM, AMRDEC, Charles M Bowden Res Lab, Redstone Arsenal, AL 35898 USA.
RP Luk, TS (reprint author), Sandia Natl Labs, POB 5800, Albuquerque, NM 87185 USA.
EM tsluk@sandia.gov
OI Campione, Salvatore/0000-0003-4655-5485
FU U.S. Department of Energy, Office of Basic Energy Sciences, Division of
Materials Sciences and Engineering; Laboratory Directed Research and
Development program at Sandia National Laboratories; U.S. Department of
Energy's National Nuclear Security Administration [DE-AC04-94AL85000];
U.S. Army Aviation and Missile Research Development and Engineering
Center
FX Portions of this work were supported by the U.S. Department of Energy,
Office of Basic Energy Sciences, Division of Materials Sciences and
Engineering, by the Laboratory Directed Research and Development program
at Sandia National Laboratories, and were performed, in part, at the
Center for Integrated Nanotechnologies, a U.S. Department of Energy,
Office of Basic Energy Sciences user facility. Sandia National
Laboratories is a multi-program laboratory managed and operated by
Sandia Corporation, a wholly owned subsidiary of Lockheed Martin
Corporation, for the U.S. Department of Energy's National Nuclear
Security Administration under Contract No. DE-AC04-94AL85000. This
research was performed while D.d.C. and M.A.V. held a National Research
Council Research Associateship award at the U.S. Army Aviation and
Missile Research Development and Engineering Center.
NR 47
TC 13
Z9 13
U1 4
U2 24
PU AMER INST PHYSICS
PI MELVILLE
PA 1305 WALT WHITMAN RD, STE 300, MELVILLE, NY 11747-4501 USA
SN 0003-6951
EI 1077-3118
J9 APPL PHYS LETT
JI Appl. Phys. Lett.
PD APR 13
PY 2015
VL 106
IS 15
AR 151103
DI 10.1063/1.4917457
PG 5
WC Physics, Applied
SC Physics
GA CG3EK
UT WOS:000353160700003
ER
PT J
AU Sangket, U
Vijasika, S
Noh, H
Chantratita, W
Klungthong, C
Yoon, IK
Fernandez, S
Rutvisuttinunt, W
AF Sangket, Unitsa
Vijasika, Sukanya
Noh, Hasnee
Chantratita, Wasun
Klungthong, Chonticha
Yoon, In Kyu
Fernandez, Stefan
Rutvisuttinunt, Wiriya
TI SNPer: An R Library for Quantitative Variant Analysis on Single
Nucleotide Polymorphisms among Influenza Virus Populations
SO PLOS ONE
LA English
DT Article
ID DNA-SEQUENCING DATA; FRAMEWORK
AB Influenza virus (IFV) can evolve rapidly leading to genetic drifts and shifts resulting in human and animal influenza epidemics and pandemics. The genetic shift that gave rise to the 2009 influenza A/H1N1 pandemic originated from a triple gene reassortment of avian, swine and human IFVs. More minor genetic alterations in genetic drift can lead to influenza drug resistance such as the H274Y mutation associated with oseltamivir resistance. Hence, a rapid tool to detect IFV mutations and the potential emergence of new virulent strains can better prepare us for seasonal influenza outbreaks as well as potential pandemics. Furthermore, identification of specific mutations by closely examining single nucleotide polymorphisms (SNPs) in IFV sequences is essential to classify potential genetic markers associated with potentially dangerous IFV phenotypes. In this study, we developed a novel R library called "SNPer" to analyze quantitative variants in SNPs among IFV subpopulations. The computational SNPer program was applied to three different subpopulations of published IFV genomic information. SNPer queried SNPs data and grouped the SNPs into (1) universal SNPs, (2) likely common SNPs, and (3) unique SNPs. SNPer outperformed manual visualization in terms of time and labor. SNPer took only three seconds with no errors in SNP comparison events compared with 40 hours with errors using manual visualization. The SNPer tool can accelerate the capacity to capture new and potentially dangerous IFV strains to mitigate future influenza outbreaks.
C1 [Sangket, Unitsa; Vijasika, Sukanya; Noh, Hasnee] Prince Songkla Univ, Fac Sci, Dept Mol Biotechnol & Bioinformat, Hat Yai, Thailand.
[Chantratita, Wasun] Mahidol Univ, Ramathibodhi Hosp, Fac Med, Dept Pathol, Bangkok 10700, Thailand.
[Klungthong, Chonticha; Yoon, In Kyu; Fernandez, Stefan; Rutvisuttinunt, Wiriya] Armed Forces Res Inst Med Sci, Dept Virol, Bangkok 10400, Thailand.
RP Sangket, U (reprint author), Prince Songkla Univ, Fac Sci, Dept Mol Biotechnol & Bioinformat, Hat Yai, Thailand.
EM unitsa.s@psu.ac.th
FU Thailand Center of Excellence for Life Sciences (TCELS)
FX This work was funded by Thailand Center of Excellence for Life Sciences
(TCELS). The funders had no role in study design, data collection and
analysis, decision to publish, or preparation of the manuscript.
NR 17
TC 1
Z9 1
U1 2
U2 10
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD APR 13
PY 2015
VL 10
IS 4
AR e0122812
DI 10.1371/journal.pone.0122812
PG 10
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA CF8XK
UT WOS:000352845100105
PM 25876137
ER
PT J
AU Calkins, M
Gates, DEA
Gates, SJ
Golding, WM
AF Calkins, Mathew
Gates, D. E. A.
Gates, S. James, Jr.
Golding, William M.
TI Think different: applying the old macintosh mantra to the computability
of the SUSY auxiliary field problem
SO JOURNAL OF HIGH ENERGY PHYSICS
LA English
DT Article
DE Space-Time Symmetries; Gauge Symmetry; Global Symmetries
ID N-EXTENDED SUPERSYMMETRY; SPINNING PARTICLES; REPRESENTATION; ADINKRAS
AB Starting with valise supermultiplets obtained from 0-branes plus field redefinitions, valise adinkra networks, and the "Garden Algebra," we discuss an architecture for algorithms that (starting from on-shell theories and, through a well-defined computation procedure), search for off-shell completions. We show in one dimension how to directly attack the notorious "off-shell auxiliary field" problem of supersymmetry with algorithms in the adinkra network-world formulation.
C1 [Calkins, Mathew; Gates, D. E. A.; Gates, S. James, Jr.] Univ Maryland, Dept Phys, Ctr String & Particle Theory, College Pk, MD 20742 USA.
[Golding, William M.] US Army, Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA.
RP Calkins, M (reprint author), Univ Maryland, Dept Phys, Ctr String & Particle Theory, College Pk, MD 20742 USA.
EM mathewpcalkins@gmail.com; deagates@terpmail.umd.edu; gatess@wam.umd.edu;
william.m.golding2.civ@mail.mil
FU National Science Foundation [PHY-0354401]; University of Maryland Center
for String & Particle Theory
FX We would like to acknowledge Professors Kevin Iga, Tristan Hubsch, Kory
Stiffler, and Stefan Mendez-Diaz for conversations. This work was
partially supported by the National Science Foundation grant PHY-0354401
and in part by the University of Maryland Center for String & Particle
Theory. Additional acknowledgment is given by M. Calkins and D.E.A.
Gates to the Center for String and Particle Theory, as well as
recognition for their participation in 2013 & 2014 SSTPRS (Student
Summer Theoretical Physics Research Session) programs. The adinkras in
this work were drawn with the aid of T. Hubsch. Finally, SJG wishes to
thank J. H. Schwarz for the introduction to this problem and
encouragement over decades.
NR 27
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PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1029-8479
J9 J HIGH ENERGY PHYS
JI J. High Energy Phys.
PD APR 13
PY 2015
IS 4
AR 056
DI 10.1007/JHEP04(2015)056
PG 25
WC Physics, Particles & Fields
SC Physics
GA CF8EE
UT WOS:000352787800003
ER
PT J
AU Chiara, CJ
Weisshaar, D
Janssens, RVF
Tsunoda, Y
Otsuka, T
Harker, JL
Walters, WB
Recchia, F
Albers, M
Alcorta, M
Bader, VM
Baugher, T
Bazin, D
Berryman, JS
Bertone, PF
Campbell, CM
Carpenter, MP
Chen, J
Crawford, HL
David, HM
Doherty, DT
Gade, A
Hoffman, CR
Honma, M
Kondev, FG
Korichi, A
Langer, C
Larson, N
Lauritsen, T
Liddick, SN
Lunderberg, E
Macchiavelli, AO
Noji, S
Prokop, C
Rogers, AM
Seweryniak, D
Shimizu, N
Stroberg, SR
Suchyta, S
Utsuno, Y
Williams, SJ
Wimmer, K
Zhu, S
AF Chiara, C. J.
Weisshaar, D.
Janssens, R. V. F.
Tsunoda, Y.
Otsuka, T.
Harker, J. L.
Walters, W. B.
Recchia, F.
Albers, M.
Alcorta, M.
Bader, V. M.
Baugher, T.
Bazin, D.
Berryman, J. S.
Bertone, P. F.
Campbell, C. M.
Carpenter, M. P.
Chen, J.
Crawford, H. L.
David, H. M.
Doherty, D. T.
Gade, A.
Hoffman, C. R.
Honma, M.
Kondev, F. G.
Korichi, A.
Langer, C.
Larson, N.
Lauritsen, T.
Liddick, S. N.
Lunderberg, E.
Macchiavelli, A. O.
Noji, S.
Prokop, C.
Rogers, A. M.
Seweryniak, D.
Shimizu, N.
Stroberg, S. R.
Suchyta, S.
Utsuno, Y.
Williams, S. J.
Wimmer, K.
Zhu, S.
TI Identification of deformed intruder states in semi-magic Ni-70
SO PHYSICAL REVIEW C
LA English
DT Article
ID COINCIDENCE DATA SETS; SUBSHELL CLOSURE; ATOMIC-NUCLEI; SHELL-MODEL;
NI-68; ISOTOPES; GRETINA; ARRAY; N=40
AB The structure of semi-magic Ni-70(28)42 was investigated following complementary multinucleon-transfer and secondary fragmentation reactions. Changes to the higher-spin, presumed negative-parity states based on observed gamma-ray coincidence relationships result in better agreement with shell-model calculations using effective interactions in the neutron f(5/2)pg(9/2) model space. The second 2(+) and (4(+)) states, however, can only be successfully described when proton excitations across the Z = 28 shell gap are included. Monte Carlo shell-model calculations suggest that the latter two states are part of a prolate-deformed intruder sequence, establishing an instance of shape coexistence at low excitation energies similar to that observed recently in neighboring Ni-68.
C1 [Chiara, C. J.; Harker, J. L.; Walters, W. B.] Univ Maryland, Dept Chem & Biochem, College Pk, MD 20742 USA.
[Chiara, C. J.; Janssens, R. V. F.; Harker, J. L.; Albers, M.; Alcorta, M.; Bertone, P. F.; Carpenter, M. P.; David, H. M.; Doherty, D. T.; Hoffman, C. R.; Korichi, A.; Lauritsen, T.; Rogers, A. M.; Seweryniak, D.; Zhu, S.] Argonne Natl Lab, Div Phys, Argonne, IL 60439 USA.
[Weisshaar, D.; Otsuka, T.; Recchia, F.; Bader, V. M.; Baugher, T.; Bazin, D.; Berryman, J. S.; Gade, A.; Langer, C.; Larson, N.; Liddick, S. N.; Lunderberg, E.; Noji, S.; Prokop, C.; Stroberg, S. R.; Suchyta, S.; Williams, S. J.; Wimmer, K.] Michigan State Univ, Natl Superconducting Cyclotron Lab, E Lansing, MI 48824 USA.
[Tsunoda, Y.; Otsuka, T.] Univ Tokyo, Dept Phys, Bunkyo Ku, Tokyo 1130033, Japan.
[Otsuka, T.; Shimizu, N.] Univ Tokyo, Ctr Nucl Study, Bunkyo Ku, Tokyo 1130033, Japan.
[Recchia, F.] Univ Padua, Dipartimento Fis & Astron, I-35131 Padua, Italy.
[Bader, V. M.; Baugher, T.; Bazin, D.; Gade, A.; Lunderberg, E.; Stroberg, S. R.] Michigan State Univ, Dept Phys & Astron, E Lansing, MI 48824 USA.
[Campbell, C. M.; Crawford, H. L.; Macchiavelli, A. O.] Univ Calif Berkeley, Lawrence Berkeley Natl Lab, Div Nucl Sci, Berkeley, CA 94720 USA.
[Chen, J.; Kondev, F. G.] Argonne Natl Lab, Nucl Engn Div, Argonne, IL 60439 USA.
[David, H. M.] Univ Edinburgh, Sch Phys & Astron, Edinburgh EH9 3JZ, Midlothian, Scotland.
[Honma, M.] Univ Aizu, Ctr Math Sci, Aizu Wakamatsu, Fukushima 9658580, Japan.
[Korichi, A.] CNRS, IN2P3, CSNSM, F-91405 Orsay, France.
[Langer, C.] Michigan State Univ, Joint Inst Nucl Astrophys, E Lansing, MI 48824 USA.
[Larson, N.; Liddick, S. N.; Prokop, C.; Suchyta, S.] Michigan State Univ, Dept Chem, E Lansing, MI 48824 USA.
[Utsuno, Y.] Japan Atom Energy Agcy, Adv Sci Res Ctr, Tokai, Ibaraki 3191195, Japan.
[Wimmer, K.] Cent Michigan Univ, Dept Phys, Mt Pleasant, MI 48859 USA.
RP Chiara, CJ (reprint author), US Army Res Lab, Adelphi, MD 20783 USA.
RI Carpenter, Michael/E-4287-2015; Gade, Alexandra/A-6850-2008; Alcorta,
Martin/G-7107-2011; OTSUKA, TAKAHARU/G-5072-2014; Hoffman,
Calem/H-4325-2016; Langer, Christoph/L-3422-2016; Larson,
Nicole/S-5997-2016
OI Carpenter, Michael/0000-0002-3237-5734; Gade,
Alexandra/0000-0001-8825-0976; Alcorta, Martin/0000-0002-6217-5004;
Hoffman, Calem/0000-0001-7141-9827; Larson, Nicole/0000-0003-0292-957X
FU US Department of Energy (DOE), Office of Science, Office of Nuclear
Physics [DE-FG02-94ER40834, DE-AC02-06CH11357]; National Science
Foundation [PHY-1102511, PHY-1430152, PHY-0822648]; DOE, National
Nuclear Security Administration [DE-NA0000979]; JSPS [258994]; DOE,
Office of Science; NSF [PHY-1102511]; DOE [DE-AC02-05CH11231]
FX The authors thank J. P. Greene (ANL) for target preparation, I. Y. Lee
(LBNL) and the GRETINA team for their efforts in making the array a
reality, and the ATLAS and NSCL operations staffs. We also thank B. A.
Brown for discussions and for providing the calculations using the
jj44pna interaction. This material is based on work supported by the US
Department of Energy (DOE), Office of Science, Office of Nuclear
Physics, under Grant No. DE-FG02-94ER40834 and Contract No.
DE-AC02-06CH11357; the National Science Foundation under Contract No.
PHY-1102511; and by the DOE, National Nuclear Security Administration,
under Award No. DE-NA0000979. C.L. acknowledges support from JINA-CEE
under Grants No. PHY-1430152 and No. PHY-0822648 of the National Science
Foundation. Y.T. acknowledges JSPS for Research Fellowship No. 258994.
GRETINA was funded by the DOE, Office of Science. Operation of the array
at NSCL was supported by the NSF under Cooperative Agreement No.
PHY-1102511 (NSCL) and DOE under Grant No. DE-AC02-05CH11231 (LBNL).
This research used resources of ANL's ATLAS facility, which is a DOE
Office of Science user facility.
NR 54
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PU AMER PHYSICAL SOC
PI COLLEGE PK
PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA
SN 0556-2813
EI 1089-490X
J9 PHYS REV C
JI Phys. Rev. C
PD APR 13
PY 2015
VL 91
IS 4
AR 044309
DI 10.1103/PhysRevC.91.044309
PG 10
WC Physics, Nuclear
SC Physics
GA CF6SE
UT WOS:000352685700001
ER
PT J
AU Yeh, IC
Lenhart, JL
Rinderspacher, BC
AF Yeh, In-Chul
Lenhart, Joseph L.
Rinderspacher, B. Christopher
TI Molecular Dynamics Simulations of Adsorption of Catechol and Related
Phenolic Compounds to Alumina Surfaces
SO JOURNAL OF PHYSICAL CHEMISTRY C
LA English
DT Article
ID FORCE-FIELD; MYTILUS-EDULIS; ADHESIVE; INTERFACE; PROTEINS; FILMS;
POTENTIALS; POLYMERS; BOEHMITE; MODEL
AB We performed atomistically detailed molecular dynamics simulations to study adsorption behaviors of catechol, which is a key functional group in marine bioadhesives, to two different alumina surfaces in both anhydrous and aqueous conditions. In anhydrous conditions, without competing interactions from water molecules, catechol adsorbed to both hydroxylated and nonhydroxylated alumina surfaces. In aqueous conditions, catechol and several analogous phenolic compounds displaced water molecules and were strongly attracted to the nonhydroxylated alumina surface, which is more hydrophobic. When comparing the phenolic moieties near the hydroxylated alumina surface in aqueous conditions, the catechol molecules displayed the strongest adsorptions mainly through cooperative hydrogen bonding interactions of two neighboring hydroxyl groups with the surface hydroxyl groups of alumina as evidenced by the longer hydrogen bonding lifetimes and the larger number of adsorbed molecules near the surface. Insights gained from this study can be used in design of novel bioadhesives or antifouling surface coatings.
C1 [Yeh, In-Chul; Lenhart, Joseph L.; Rinderspacher, B. Christopher] US Army Res Lab, Macromol Sci & Technol Branch, Mat & Mfg Sci Div, Aberdeen Proving Ground, MD 21005 USA.
RP Rinderspacher, BC (reprint author), US Army Res Lab, Macromol Sci & Technol Branch, Mat & Mfg Sci Div, Aberdeen Proving Ground, MD 21005 USA.
EM berend.c.rinderspacher.civ@mail.mil
FU Postgraduate Research Participation Program at the U.S. Army Research
Laboratory (ARL)
FX This work was supported in part by an appointment to the Postgraduate
Research Participation Program at the U.S. Army Research Laboratory
(ARL) administered by the Oak Ridge Institute for Science and Education
through an interagency agreement between the U.S. Department of Energy
and ARL. The DoD HPC Modernization Office supported this project by
supplying supercomputer time under the Computing Challenge Project CSM.
We thank Drs. Joshua Orlicki and Daniel Knorr for helpful discussions
and comments on our work.
NR 52
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U1 11
U2 57
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 1932-7447
J9 J PHYS CHEM C
JI J. Phys. Chem. C
PD APR 9
PY 2015
VL 119
IS 14
BP 7721
EP 7731
DI 10.1021/jp512780s
PG 11
WC Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science,
Multidisciplinary
SC Chemistry; Science & Technology - Other Topics; Materials Science
GA CF8PC
UT WOS:000352823300019
ER
PT J
AU Childs, JD
Fritz, JM
Wu, SS
Flynn, TW
Wainner, RS
Robertson, EK
Kim, FS
George, SZ
AF Childs, John D.
Fritz, Julie M.
Wu, Samuel S.
Flynn, Timothy W.
Wainner, Robert S.
Robertson, Eric K.
Kim, Forest S.
George, Steven Z.
TI Implications of early and guideline adherent physical therapy for low
back pain on utilization and costs
SO BMC HEALTH SERVICES RESEARCH
LA English
DT Article
DE Guideline adherence; Low back pain; Physical therapy; Timing;
Utilization and costs
ID CLINICAL-PRACTICE GUIDELINE; PRIMARY-CARE; SOCIETY/AMERICAN COLLEGE;
MILITARY PERSONNEL; UNITED-STATES; HEALTH-CARE; DISABILITY; MANAGEMENT;
RADICULOPATHY; EXPENDITURES
AB Background: Initial management decisions following a new episode of low back pain (LBP) are thought to have profound implications for health care utilization and costs. The purpose of this study was to evaluate the impact of early and guideline adherent physical therapy for low back pain on utilization and costs within the Military Health System (MHS).
Methods: Patients presenting to a primary care setting with a new complaint of LBP from January 1, 2007 to December 31, 2009 were identified from the MHS Management Analysis and Reporting Tool. Descriptive statistics, utilization, and costs were examined on the basis of timing of referral to physical therapy and adherence to practice guidelines over a 2-year period. Utilization outcomes (advanced imaging, lumbar injections or surgery, and opioid use) were compared using adjusted odds ratios with 99% confidence intervals. Total LBP-related health care costs over the 2-year follow-up were compared using linear regression models.
Results: 753,450 eligible patients with a primary care visit for LBP between 18-60 years of age were considered. Physical therapy was utilized by 16.3% (n = 122,723) of patients, with 24.0% (n = 17,175) of those receiving early physical therapy that was adherent to recommendations for active treatment. Early referral to guideline adherent physical therapy was associated with significantly lower utilization for all outcomes and 60% lower total LBP-related costs.
Conclusions: The potential for cost savings in the MHS from early guideline adherent physical therapy may be substantial. These results also extend the findings from similar studies in civilian settings by demonstrating an association between early guideline adherent care and utilization and costs in a single payer health system. Future research is necessary to examine which patients with LBP benefit early physical therapy and determine strategies for providing early guideline adherent care.
C1 [Childs, John D.] US Army, Baylor Univ, Army Med Dept Ctr & Sch, Doctoral Program Phys Therapy, Ft Sam Houston, TX 78234 USA.
[Fritz, Julie M.] Univ Utah, Dept Phys Therapy, Salt Lake City, UT 84108 USA.
[Wu, Samuel S.] Univ Florida, Coll Publ Hlth & Hlth Profess, Dept Hlth Serv Res Management & Policy, Gainesville, FL 32610 USA.
[Flynn, Timothy W.; Wainner, Robert S.] South Coll, FIM Sch Phys Therapy, Knoxville, TN 37909 USA.
[Robertson, Eric K.] Univ Texas El Paso, Doctor Phys Therapy Program, El Paso, TX 79968 USA.
[Kim, Forest S.] US Army Baylor, US Army Med Dept Ctr & Sch, MHA MBA Program, San Antonio, TX 78234 USA.
[George, Steven Z.] Univ Florida, Dept Phys Therapy, Brooks PHHP Res Collaborat, Gainesville, FL 32610 USA.
RP Childs, JD (reprint author), US Army, Baylor Univ, Army Med Dept Ctr & Sch, Doctoral Program Phys Therapy, 3151 Scott Rd,Rm 2307,JBSA Ft, Ft Sam Houston, TX 78234 USA.
EM childsjd@gmail.com
FU Texas State University; Air Force Medical Service
FX The authors would like to acknowledge Maurine R. Tapscott, Senior Health
Systems Specialist, Program Analysis & Evaluation, HQ MEDCOM A&E
Division for her efforts in extracting the data and providing the data
dictionary for the data analysis. This study was funded by intramural
grant programs at Texas State University and the Air Force Medical
Service. The funding agencies played no role in the study design, data
collection, analysis, interpretation of data, writing of manuscript, or
decision to submit the manuscript for publication.
NR 29
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Z9 14
U1 0
U2 7
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1472-6963
J9 BMC HEALTH SERV RES
JI BMC Health Serv. Res.
PD APR 9
PY 2015
VL 15
AR 150
DI 10.1186/s12913-015-0830-3
PG 10
WC Health Care Sciences & Services
SC Health Care Sciences & Services
GA CF5OK
UT WOS:000352606400001
PM 25880898
ER
PT J
AU Wang, H
Nandigana, VVR
Jo, KD
Aluru, NR
Timperman, AT
AF Wang, Han
Nandigana, Vishal V. R.
Jo, Kyoo Dong
Aluru, Narayana R.
Timperman, Aaron T.
TI Controlling the Ionic Current Rectification Factor of a
Nanofluidic/Microfluidic Interface with Symmetric Nanocapillary
Interconnects
SO ANALYTICAL CHEMISTRY
LA English
DT Article
ID SINGLE CONICAL NANOPORES; NANOFLUIDIC DIODE; TRANSPORT-PROPERTIES;
DEVICES; MEMBRANE; SYSTEM; CHARGE
AB The current rectification factor can be tailored by changing the degree of asymmetry between the fluid baths on opposite sides of a nanocapillary membrane (NCM). A symmetric device with symmetric fluid baths connected to opposite sides of the NCM did not rectify ionic current; while a NCM connected between fluid baths with a 32-fold difference in cross-sectional area produced a rectification factor of 75. The data suggests that the primary mechanism for the current rectification is the change in cross-sectional area of the fluid baths and the polarity dependent propagation of the enriched and depleted concentration polarization (CP) zones into these regions. An additional contribution to the increasing rectification factor with increasing bath asymmetry appears to be a result of electroconvection in the macropore, with inside diameters (IDs) of 625 and 850-mu m. Power spectral density (PSD) analysis reveals chaotic oscillations that are consistent with electroconvection in the I-t data of the 625 and 850-mu m ID macropore devices. In the ON state, current rectification keeps ionic transport toward the NCM high, increasing the speed of processes like sample enrichment. A simple means is provided to fabricate fluidic diodes with tailored current rectification factors.
C1 [Jo, Kyoo Dong; Timperman, Aaron T.] US Army Corps Engn, Construct Engn Res Lab, Champaign, IL 61826 USA.
[Wang, Han] W Virginia Univ, Dept Chem, Morgantown, WV 26505 USA.
[Nandigana, Vishal V. R.; Aluru, Narayana R.] Univ Illinois, Beckman Inst Adv Sci & Technol, Urbana, IL 61801 USA.
RP Timperman, AT (reprint author), US Army Corps Engn, Construct Engn Res Lab, 2902 Newmark Dr, Champaign, IL 61826 USA.
EM aaron.timperman@usace.army.mil
RI Aluru, N/A-4617-2014
FU U.S. Army Environmental Quality and Installations Basic Research Program
FX This publication represents research that was funded by the U.S. Army
Environmental Quality and Installations Basic Research Program.
NR 38
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Z9 4
U1 2
U2 16
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0003-2700
EI 1520-6882
J9 ANAL CHEM
JI Anal. Chem.
PD APR 7
PY 2015
VL 87
IS 7
BP 3598
EP 3605
DI 10.1021/ac5019638
PG 8
WC Chemistry, Analytical
SC Chemistry
GA CF6ID
UT WOS:000352659500009
PM 25803122
ER
PT J
AU Petrie, JR
Wieland, KA
Timmerwilke, JM
Barron, SC
Burke, RA
Newburgh, GA
Burnette, JE
Fischer, GA
Edelstein, AS
AF Petrie, J. R.
Wieland, K. A.
Timmerwilke, J. M.
Barron, S. C.
Burke, R. A.
Newburgh, G. A.
Burnette, J. E.
Fischer, G. A.
Edelstein, A. S.
TI A multi-state magnetic memory dependent on the permeability of Metglas
SO APPLIED PHYSICS LETTERS
LA English
DT Article
ID BULK METALLIC GLASSES; AMORPHOUS-ALLOYS; CRYSTALLIZATION; EVOLUTION;
BEHAVIOR; KINETICS
AB A three-state magnetic memory was developed based on differences in the magnetic permeability of a soft ferromagnetic media, Metglas 2826MB (Fe40Ni38Mo4B18). By heating bits of a 250 nm thick Metglas film with 70-100 mW of laser power, we were able to tune the local microstructure, and hence, the permeability. Ternary memory states were created by using lower laser power to enhance the initial permeability through localized atomic rearrangement and higher power to reduce the permeability through crystallization. The permeability of the bits was read by detecting variations in an external 32 Oe probe field within 10 mu m of the media via a magnetic tunnel junction read head. Compared to data based on remanent magnetization, these multi-permeability bits have enhanced insensitivity to unexpected field and temperature changes. We found that data was not corrupted after exposure to fields of 1 T or temperatures of 423 K, indicating the effectiveness of this multi-state approach for safely storing large amounts of data. (C) 2015 AIP Publishing LLC.
C1 [Petrie, J. R.; Wieland, K. A.; Timmerwilke, J. M.; Burke, R. A.; Newburgh, G. A.; Fischer, G. A.; Edelstein, A. S.] US Army Res Lab, Adelphi, MD 20783 USA.
[Barron, S. C.] Natl Inst Stand & Technol, Gaithersburg, MD 20899 USA.
[Burnette, J. E.] Spin Transfer Technol, Boston, MA 02110 USA.
RP Petrie, JR (reprint author), US Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA.
NR 33
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U1 1
U2 21
PU AMER INST PHYSICS
PI MELVILLE
PA 1305 WALT WHITMAN RD, STE 300, MELVILLE, NY 11747-4501 USA
SN 0003-6951
EI 1077-3118
J9 APPL PHYS LETT
JI Appl. Phys. Lett.
PD APR 6
PY 2015
VL 106
IS 14
AR 142403
DI 10.1063/1.4917247
PG 4
WC Physics, Applied
SC Physics
GA CF8OF
UT WOS:000352820700023
ER
PT J
AU Vasan, S
Rerks-Ngarm, S
Gilbert, P
Haynes, B
Nitayapan, S
Pitisuttihum, P
Kaewkungwal, J
Excler, JL
Robb, M
Michael, N
Kim, J
O'Connell, R
AF Vasan, Sandhya
Rerks-Ngarm, Supachai
Gilbert, Peter
Haynes, Barton
Nitayapan, Sorachai
Pitisuttihum, Punnee
Kaewkungwal, Jaranit
Excler, Jean-Louis
Robb, Merlin
Michael, Nelson
Kim, Jerome
O'Connell, Robert
TI Letter to the Editor on: The RV144 vaccine regimen was not associated
with enhancement of infection
SO HUMAN VACCINES & IMMUNOTHERAPEUTICS
LA English
DT Letter
ID ALVAC-HIV VCP1521; EFFICACY TRIAL; THAILAND; AIDSVAX
C1 [Vasan, Sandhya; O'Connell, Robert] USAMC AFRIMS, US Mil HIV Res Program, Armed Forces Res Inst Med Sci, US Army Component, Bangkok, Thailand.
[Rerks-Ngarm, Supachai] Minist Publ Hlth, Dept Dis Control, Nonthaburi, Thailand.
[Gilbert, Peter] Fred Hutchinson Canc Res Ctr, Stat Ctr HIV AIDS Res & Prevent, Seattle, WA 98104 USA.
[Haynes, Barton] Duke Univ, Sch Med, Human Vaccine Inst, Durham, NC USA.
[Haynes, Barton] Duke Univ, Sch Med, Dept Med, Durham, NC 27706 USA.
[Haynes, Barton] Duke Univ, Sch Med, Dept Immunol, Durham, NC USA.
[Nitayapan, Sorachai] Armed Forces Res Inst Med Sci, Royal Thai Army Component, Bangkok 10400, Thailand.
[Pitisuttihum, Punnee; Kaewkungwal, Jaranit] Mahidol Univ, Fac Trop Med, Bangkok, Thailand.
[Excler, Jean-Louis; Robb, Merlin; Michael, Nelson; Kim, Jerome] US Mil Res Program, Vaccine Clin Dev, Bethesda, MD USA.
RP O'Connell, R (reprint author), USAMC AFRIMS, US Mil HIV Res Program, Armed Forces Res Inst Med Sci, US Army Component, Bangkok, Thailand.
EM robert.oconnell@afrims.org
NR 7
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U1 1
U2 3
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 2164-5515
EI 2164-554X
J9 HUM VACC IMMUNOTHER
JI Human Vaccines Immunother.
PD APR 3
PY 2015
VL 11
IS 4
BP 1036
EP 1037
DI 10.1080/21645515.2015.1010970
PG 2
WC Biotechnology & Applied Microbiology; Immunology
SC Biotechnology & Applied Microbiology; Immunology
GA CH3WP
UT WOS:000353961900037
PM 25746053
ER
PT J
AU Perliger, A
Zaidise, E
AF Perliger, Arie
Zaidise, Eran
TI The Peculiar Victory of The National Camp in the 2013 Israeli Election
SO ISRAEL AFFAIRS
LA English
DT Article
DE far right; Israeli elections 2013; Israeli right; 19th Knesset; settlers
movement
ID PARTIES
AB This article argues that attempts to characterize the outcome of the elections to the 19th Knesset as a defeat of the Israeli right are misleading. By using a three-dimensional analysis of the ideological makeup of the Knesset, based on the ideological manifestos of the parties, the socio-demographic profiles of Knesset members and analyses of election results utilizing electoral data and socio-demographic data obtained from Israel's Central Bureau of Statistics (CBS), the article claims that the 19th Knesset is no less right-leaning than its predecessor. Hence, contrary to some commentators in both the media and academia, the 2013 elections represent a true landmark for the settlers. For the first time since the movement appeared in the 1970s, it managed to obtain a solid base in the Knesset.
C1 [Perliger, Arie] US Mil Acad, Dept Social Sci, West Point, NY 10996 USA.
[Zaidise, Eran] Western Galilee Coll, Dept Polit Sci, Akko, Israel.
RP Perliger, A (reprint author), US Mil Acad, Dept Social Sci, West Point, NY 10996 USA.
EM aperliger@gmail.com
NR 24
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U1 0
U2 1
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND
SN 1353-7121
EI 1743-9086
J9 ISR AFF
JI Isr. Aff.
PD APR 3
PY 2015
VL 21
IS 2
SI SI
BP 195
EP 208
DI 10.1080/13537121.2015.1008243
PG 14
WC Area Studies
SC Area Studies
GA CD2BT
UT WOS:000350879400002
ER
PT J
AU Guillen, J
Lichiere, J
Rabah, N
Beitzel, BF
Canard, B
Coutard, B
AF Guillen, Jaime
Lichiere, Julie
Rabah, Nadia
Beitzel, Brett F.
Canard, Bruno
Coutard, Bruno
TI Structural and biophysical analysis of sequence insertions in the
Venezuelan Equine Encephalitis Virus macro domain
SO VIRUS RESEARCH
LA English
DT Article
DE Alphavirus; Non-structural protein; Macro domain; Sequence insertion;
Structure; Biophysical studies
ID STRAND RNA-SYNTHESIS; REPLICASE PROTEIN NSP2; SINDBIS-VIRUS;
MINUS-STRAND; NONSTRUCTURAL PROTEIN; IN-VITRO; IDENTIFICATION;
MUTATIONS; CHIKUNGUNYA; PHOSPHORYLATION
AB Random transposon insertions in viral genomes can be used to reveal genomic regions important for virus replication. We used these genomic data to evaluate at the protein level the effect of such insertions on the Venezuelan Equine Encephalitis Virus nsP3 macro domain. The structural analysis showed that transposon insertions occur mainly in loops connecting the secondary structure elements. Some of the insertions leading to a temperature sensitive viral phenotype (ts) are close to the cleavage site between nsP2 and nsP3 or the ADP-ribose binding site, two important functions of the macro domain. Using four mutants mimicking the transposon insertions, we confirmed that these insertions can affect the macro domain properties without disrupting the overall structure of the protein. (C) 2015 Elsevier B.V. All rights reserved.
C1 [Guillen, Jaime; Lichiere, Julie; Rabah, Nadia; Canard, Bruno; Coutard, Bruno] CNRS, AFMB UMR 7257, F-13288 Marseille, France.
[Guillen, Jaime; Lichiere, Julie; Rabah, Nadia; Canard, Bruno; Coutard, Bruno] Aix Marseille Univ, AFMB UMR 7257, F-13288 Marseille 09, France.
[Beitzel, Brett F.] US Army, Ctr Genome Sci, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA.
RP Coutard, B (reprint author), Aix Marseille Univ, AFMB UMR 7257, F-13288 Marseille 09, France.
EM bruno.coutard@afmb.univ-mrs.fr
RI Guillen, Jaime/K-2892-2014
OI Guillen, Jaime/0000-0001-7415-1512
FU European Union [260644]; MEC [BFS-2010-1217]; Intra-European Marie Curie
fellowship [299753]
FX This work was supported by the European Union Seventh Framework
Programme FP7/2007-2013 [Project SILVER Grant 260644]. J.G. was
recipient of a postdoctoral fellowship from MEC (BFS-2010-1217) and an
Intra-European Marie Curie fellowship (FP7-PEOPLE-2011-IEF, no 299753).
NR 42
TC 0
Z9 0
U1 0
U2 2
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0168-1702
EI 1872-7492
J9 VIRUS RES
JI Virus Res.
PD APR 2
PY 2015
VL 201
BP 94
EP 100
DI 10.1016/j.virusres.2015.02.018
PG 7
WC Virology
SC Virology
GA CI8MP
UT WOS:000355026700013
PM 25725151
ER
PT J
AU Maxwell, P
Maciejewski, AA
Siegel, HJ
Potter, J
Smith, J
AF Maxwell, Paul
Maciejewski, Anthony A.
Siegel, Howard Jay
Potter, Jerry
Smith, Jay
TI Dynamic rescheduling heuristics for military village search environments
SO JOURNAL OF DEFENSE MODELING AND SIMULATION-APPLICATIONS METHODOLOGY
TECHNOLOGY-JDMS
LA English
DT Article
DE resource allocation; robustness; stochastic; robust resource allocation;
dynamic rescheduling; village search
ID TRAVELING SALESMAN PROBLEM; VEHICLE-ROUTING PROBLEM;
RESOURCE-ALLOCATION; GENETIC ALGORITHMS; INDEPENDENT TASKS; ROBUSTNESS;
SYSTEMS; MODEL
AB On the modern battlefield cordon and search missions (also known as village searches) are conducted daily. Creating resource allocations that link search teams (e.g. soldiers, robots, unmanned aerial vehicles, military working dogs) to target buildings is difficult and time consuming in the static planning environment and is even more challenging in a time-constrained dynamic environment. Conducting dynamic resource allocation during the execution of a military village search mission is beneficial especially when the time to develop a static plan is limited and hence the quality of the plan is relatively poor. Dynamic heuristics can help improve the static plan because they are able to incorporate current state information that is unavailable prior to mission execution and thus produce more accurate results than static heuristics alone can achieve. There are currently no automated means to create these dynamic resource allocations for military use. Using robustness concepts, this paper proposes and compares dynamic resource allocation heuristics that create mission plans that are resilient against uncertainty in the environment and that save valuable time for military planning staff.
C1 [Maxwell, Paul] US Mil Acad, Dept Elect Engn & Comp Sci, West Point, NY 10996 USA.
[Maciejewski, Anthony A.; Siegel, Howard Jay; Potter, Jerry] Colorado State Univ, Dept Elect & Comp Engn, Ft Collins, CO 80523 USA.
[Smith, Jay] Lagrange Syst Inc, Boulder, CO USA.
RP Maxwell, P (reprint author), US Mil Acad, Dept Elect Engn & Comp Sci, West Point, NY 10996 USA.
EM paul.maxwell@us.army.mil
NR 33
TC 0
Z9 0
U1 0
U2 1
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1548-5129
EI 1557-380X
J9 J DEF MODEL SIMUL-AP
JI J. Def. Model. Simul.-Appl. Methodol. Technol.-JDMS
PD APR
PY 2015
VL 12
IS 2
BP 139
EP 156
DI 10.1177/1548512913518665
PG 18
WC Engineering, Multidisciplinary
SC Engineering
GA CV7YU
UT WOS:000364494100005
ER
PT J
AU Reddy, KR
Beavers, KL
Gordon, S
Harrison, S
Reau, N
Yozviak, J
DeLedinghen, V
Conway, B
Tse, E
Bhore, R
Boparai, N
Hughes, E
Swenson, ES
Yin, PD
AF Reddy, K. Rajender
Beavers, K. L.
Gordon, S.
Harrison, S.
Reau, N.
Yozviak, J.
DeLedinghen, V.
Conway, B.
Tse, E.
Bhore, R.
Boparai, N.
Hughes, E.
Swenson, E. S.
Yin, P. D.
TI EFFECT OF BASELINE FACTORS ON RESPONSE TO THE FIXED-DOSE COMBINATION OF
DACLATASVIR (DCV), ASUNAPREVIR (ASV) AND BECLABUVIR (BCV) IN
NON-CIRRHOTIC PATIENTS WITH HCV GENOTYPE 1 INFECTION
SO JOURNAL OF HEPATOLOGY
LA English
DT Meeting Abstract
CT 50th International Liver Congress of the
European-Association-for-the-Study-of-the-Liver
CY APR 22-26, 2015
CL Vienna, AUSTRIA
SP European Assoc Study Liver
C1 [Reddy, K. Rajender] Univ Penn, Philadelphia, PA 19104 USA.
[Beavers, K. L.] Med Univ S Carolina, Charleston, SC USA.
[Gordon, S.] Henry Ford Hlth Syst, Detroit, MI USA.
[Harrison, S.] Brooke Army Med Ctr, San Antonio, TX USA.
[Reau, N.] Univ Chicago, Med Ctr, Chicago, IL 60637 USA.
[Yozviak, J.] Lehigh Valley Hlth Network, Allentown, PA USA.
[DeLedinghen, V.] Hop Haut Leveque, Pessac, France.
[Conway, B.] Vancouver Infect Dis Ctr, Vancouver, BC, Canada.
[Tse, E.] Royal Adelaide Hosp, Adelaide, SA 5000, Australia.
[Bhore, R.; Boparai, N.; Hughes, E.] Bristol Myers Squibb Res & Dev, Princeton, NJ USA.
[Swenson, E. S.; Yin, P. D.] Bristol Myers Squibb Res & Dev, Wallingford, CT USA.
EM adrienne.tracey@articulatescience.com
NR 0
TC 0
Z9 0
U1 0
U2 0
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0168-8278
EI 1600-0641
J9 J HEPATOL
JI J. Hepatol.
PD APR
PY 2015
VL 62
SU 2
MA P0889
BP S676
EP S677
PG 2
WC Gastroenterology & Hepatology
SC Gastroenterology & Hepatology
GA CT5EL
UT WOS:000362830900085
ER
PT J
AU Audet, G
Quinn, C
Leon, L
AF Audet, Gerald
Quinn, Carrie
Leon, Lisa
TI Point-of-care cTnI Tests Accurately Predict Heat Stroke Severity; Proof
of Concept for a Heat Stroke Field Test
SO FASEB JOURNAL
LA English
DT Meeting Abstract
CT Experimental Biology Meeting
CY MAR 28-APR 01, 2015
CL Boston, MA
SP Amer Assoc Anatomists, Amer Physiol Soc, Amer Soc Biochem & Mol Biol, ASIP, ASN, ASPET
C1 [Audet, Gerald; Quinn, Carrie; Leon, Lisa] US Army Res Inst Environm Med, Thermal Mt Med, Natick, MA USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
EI 1530-6860
J9 FASEB J
JI Faseb J.
PD APR
PY 2015
VL 29
SU 1
MA 993.14
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA CS0BT
UT WOS:000361722707221
ER
PT J
AU Barr, J
Dubick, M
Bowman, P
AF Barr, Johnny
Dubick, Michael
Bowman, Phillip
TI In Vitro Hypoxia/Reoxygenation Modeling of Ischemia/Reperfusion Injury
Using Glucose Oxidase in Human Cells
SO FASEB JOURNAL
LA English
DT Meeting Abstract
CT Experimental Biology Meeting
CY MAR 28-APR 01, 2015
CL Boston, MA
SP Amer Assoc Anatomists, Amer Physiol Soc, Amer Soc Biochem & Mol Biol, ASIP, ASN, ASPET
C1 [Barr, Johnny; Dubick, Michael; Bowman, Phillip] US Army Inst Surg Res, Damage Control Resuscitat, San Antonio, TX USA.
NR 0
TC 0
Z9 0
U1 1
U2 1
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
EI 1530-6860
J9 FASEB J
JI Faseb J.
PD APR
PY 2015
VL 29
SU 1
MA 977.4
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA CS0BT
UT WOS:000361722707071
ER
PT J
AU Boeri, M
Kasten, S
Cerasoli, D
AF Boeri, Michael
Kasten, Shane
Cerasoli, Douglas
TI Inhibition of Human Acetylcholinesterase by Enantiomers of V-Type
Chemical Warfare Nerve Agents and Analogs
SO FASEB JOURNAL
LA English
DT Meeting Abstract
CT Experimental Biology Meeting
CY MAR 28-APR 01, 2015
CL Boston, MA
SP Amer Assoc Anatomists, Amer Physiol Soc, Amer Soc Biochem & Mol Biol, ASIP, ASN, ASPET
C1 [Boeri, Michael; Kasten, Shane; Cerasoli, Douglas] US Army, Med Res Inst Chem Def, Div Res, Arlington, VA USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
EI 1530-6860
J9 FASEB J
JI Faseb J.
PD APR
PY 2015
VL 29
SU 1
MA 721.4
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA CS0BT
UT WOS:000361722701234
ER
PT J
AU Brunelle, A
Blum-Johnston, C
Wee, C
Blood, Q
Wilson, R
Romero, M
Francis, M
Taylor, M
Longo, L
Wilson, S
AF Brunelle, Alexander
Blum-Johnston, Carla
Wee, Chelsea
Blood, Quintin
Wilson, Rachael
Romero, Monica
Francis, Michael
Taylor, Mark
Longo, Lawrence
Wilson, Sean
TI High altitude Gestation and Prenatal Programming of Bradykinin Induced
Pulmonary Endothelial Ca2+ Responses and Arterial Vasorelaxation in
Fetal and Newborn Lamb
SO FASEB JOURNAL
LA English
DT Meeting Abstract
CT Experimental Biology Meeting
CY MAR 28-APR 01, 2015
CL Boston, MA
SP Amer Assoc Anatomists, Amer Physiol Soc, Amer Soc Biochem & Mol Biol, ASIP, ASN, ASPET
C1 [Brunelle, Alexander; Blum-Johnston, Carla; Wee, Chelsea; Blood, Quintin; Wilson, Rachael; Longo, Lawrence; Wilson, Sean] Loma Linda Univ, SOM, Ctr Perinatal Biol, Loma Linda, CA 92350 USA.
[Romero, Monica; Wilson, Sean] Loma Linda Univ, LLUSOM, Adv Imaging & Microscopy Core, Loma Linda, CA 92350 USA.
[Francis, Michael; Taylor, Mark] USA, Coll Med, Physiol, Mobile, AL USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
EI 1530-6860
J9 FASEB J
JI Faseb J.
PD APR
PY 2015
VL 29
SU 1
MA 1051.1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA CS0BT
UT WOS:000361722708126
ER
PT J
AU Cadieux, CL
Wang, HY
Zhang, YC
Koenig, J
Shih, TM
McDonough, J
Koh, J
Cerasoli, D
AF Cadieux, C. Linn
Wang, Haoyu
Zhang, Yuchen
Koenig, Jeffrey
Shih, Tsung-Ming
McDonough, John
Koh, John
Cerasoli, Douglas
TI Phosphonylated Acetylcholinesterase: Probing the Mechanism of a Small
Molecule Reactivator
SO FASEB JOURNAL
LA English
DT Meeting Abstract
CT Experimental Biology Meeting
CY MAR 28-APR 01, 2015
CL Boston, MA
SP Amer Assoc Anatomists, Amer Physiol Soc, Amer Soc Biochem & Mol Biol, ASIP, ASN, ASPET
C1 [Cadieux, C. Linn; Koenig, Jeffrey; Shih, Tsung-Ming; McDonough, John; Cerasoli, Douglas] US Army, Med Res Inst Chem Def, Div Res, Aberdeen Proving Ground, MD 21010 USA.
[Wang, Haoyu; Zhang, Yuchen; Koh, John] Univ Delaware, Dept Chem & Biochem, Newark, DE 19716 USA.
NR 0
TC 0
Z9 0
U1 3
U2 3
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
EI 1530-6860
J9 FASEB J
JI Faseb J.
PD APR
PY 2015
VL 29
SU 1
MA 721.7
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA CS0BT
UT WOS:000361722701237
ER
PT J
AU Dubick, M
Barr, J
Bowman, P
AF Dubick, Michael
Barr, Johnny
Bowman, Phillip
TI Mechanism of Cell Death Induced by in Vitro Hypoxia/Reoxygenation Using
Glucose Oxidase in Human Cells
SO FASEB JOURNAL
LA English
DT Meeting Abstract
CT Experimental Biology Meeting
CY MAR 28-APR 01, 2015
CL Boston, MA
SP Amer Assoc Anatomists, Amer Physiol Soc, Amer Soc Biochem & Mol Biol, ASIP, ASN, ASPET
C1 [Dubick, Michael; Barr, Johnny; Bowman, Phillip] US Army Inst Surg Res, Damage Control Resuscitat, San Antonio, TX USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
EI 1530-6860
J9 FASEB J
JI Faseb J.
PD APR
PY 2015
VL 29
SU 1
MA 977.3
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA CS0BT
UT WOS:000361722707070
ER
PT J
AU Freese, E
Gist, N
Acitelli, R
McConnell, W
Beck, C
Hausman, D
Murrow, J
Cureton, K
Evans, E
AF Freese, Eric
Gist, Nicholas
Acitelli, Rachelle
McConnell, Whitni
Beck, Catherine
Hausman, Dorothy
Murrow, Jonathan
Cureton, Kirk
Evans, Ellen
TI Acute and Chronic Effects of Sprint Interval Training on Postprandial
Lipemia in Women At-Risk for Metabolic Syndrome
SO FASEB JOURNAL
LA English
DT Meeting Abstract
CT Experimental Biology Meeting
CY MAR 28-APR 01, 2015
CL Boston, MA
SP Amer Assoc Anatomists, Amer Physiol Soc, Amer Soc Biochem & Mol Biol, ASIP, ASN, ASPET
C1 [Freese, Eric; Acitelli, Rachelle; McConnell, Whitni; Beck, Catherine; Cureton, Kirk; Evans, Ellen] Univ Georgia, Kinesiol, Athens, GA 30602 USA.
[Gist, Nicholas] US Mil Acad, Phys Educ, West Point, NY 10996 USA.
[Hausman, Dorothy] Univ Georgia, Foods & Nutr, Athens, GA 30602 USA.
[Murrow, Jonathan] Georgia Regents Univ Univ Georgia Med Partnership, Athens, GA USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
EI 1530-6860
J9 FASEB J
JI Faseb J.
PD APR
PY 2015
VL 29
SU 1
MA 1055.7
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA CS0BT
UT WOS:000361722708165
ER
PT J
AU Hinojosa-Laborde, C
Mulligan, J
Grudic, G
Convertino, V
AF Hinojosa-Laborde, Carmen
Mulligan, Jane
Grudic, Greg
Convertino, Victor
TI Comparison of Compensatory Reserve Index during Lower Body Negative
Pressure and Hemorrhage
SO FASEB JOURNAL
LA English
DT Meeting Abstract
CT Experimental Biology Meeting
CY MAR 28-APR 01, 2015
CL Boston, MA
SP Amer Assoc Anatomists, Amer Physiol Soc, Amer Soc Biochem & Mol Biol, ASIP, ASN, ASPET
C1 [Hinojosa-Laborde, Carmen; Convertino, Victor] US Army Inst Surg Res, Tact Combat Casualty Care Res, Ft Sam Houston, TX USA.
[Mulligan, Jane; Grudic, Greg] Flashback Technol Inc, R&D, Boulder, CO USA.
NR 0
TC 0
Z9 0
U1 2
U2 2
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
EI 1530-6860
J9 FASEB J
JI Faseb J.
PD APR
PY 2015
VL 29
SU 1
MA 800.8
PG 2
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA CS0BT
UT WOS:000361722703044
ER
PT J
AU Jahns, L
Stote, K
Madanat, H
Cole, R
AF Jahns, Lisa
Stote, Kim
Madanat, Hala
Cole, Renee
TI Women's Motivations for Eating
SO FASEB JOURNAL
LA English
DT Meeting Abstract
CT Experimental Biology Meeting
CY MAR 28-APR 01, 2015
CL Boston, MA
SP Amer Assoc Anatomists, Amer Physiol Soc, Amer Soc Biochem & Mol Biol, ASIP, ASN, ASPET
C1 [Jahns, Lisa] ARS, GFHNRC, USDA, New York, NY USA.
[Stote, Kim] SUNY Empire State Coll, Hlth Sci, New York, NY USA.
[Madanat, Hala] San Diego State Univ, Grad Sch Publ Hlth, San Diego, CA 92182 USA.
[Cole, Renee] US Army, Mil Nutr Div, Environm Med Res Inst, Washington, DC USA.
NR 0
TC 0
Z9 0
U1 2
U2 2
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
EI 1530-6860
J9 FASEB J
JI Faseb J.
PD APR
PY 2015
VL 29
SU 1
MA 736.20
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA CS0BT
UT WOS:000361722702064
ER
PT J
AU Klemcke, H
Bynum, J
Bowman, P
AF Klemcke, H.
Bynum, J.
Bowman, P.
TI Cardiac mRNA Expression in Inbred Rat Strains Divergent in Survival Time
after Hemorrhage
SO FASEB JOURNAL
LA English
DT Meeting Abstract
CT Experimental Biology Meeting
CY MAR 28-APR 01, 2015
CL Boston, MA
SP Amer Assoc Anatomists, Amer Physiol Soc, Amer Soc Biochem & Mol Biol, ASIP, ASN, ASPET
C1 [Klemcke, H.; Bynum, J.; Bowman, P.] US Army Inst Surg Res, DCR, Ft Sam Houston, TX USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
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J9 FASEB J
JI Faseb J.
PD APR
PY 2015
VL 29
SU 1
MA 665.6
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA CS0BT
UT WOS:000361722700030
ER
PT J
AU Leon, L
Dineen, S
AF Leon, Lisa
Dineen, Shauna
TI Prior Viral Infection Increases Heat Stroke Severity in Mice
SO FASEB JOURNAL
LA English
DT Meeting Abstract
CT Experimental Biology Meeting
CY MAR 28-APR 01, 2015
CL Boston, MA
SP Amer Assoc Anatomists, Amer Physiol Soc, Amer Soc Biochem & Mol Biol, ASIP, ASN, ASPET
C1 [Leon, Lisa; Dineen, Shauna] US Army Res Inst Environm Med, Thermal Mt Med Div, Natick, MA USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
EI 1530-6860
J9 FASEB J
JI Faseb J.
PD APR
PY 2015
VL 29
SU 1
MA 993.10
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA CS0BT
UT WOS:000361722707217
ER
PT J
AU McClung, H
Margolis, L
Murphy, N
Lin, G
Hydren, J
Davis, B
Young, A
Pasiakos, S
AF McClung, Holly
Margolis, Lee
Murphy, Nancy
Lin, Gregory
Hydren, Jay
Davis, Betty
Young, Andrew
Pasiakos, Stefan
TI Net Protein Balance after Load Carriage Exercise is Enhanced by Amino
Acid Supplementation
SO FASEB JOURNAL
LA English
DT Meeting Abstract
CT Experimental Biology Meeting
CY MAR 28-APR 01, 2015
CL Boston, MA
SP Amer Assoc Anatomists, Amer Physiol Soc, Amer Soc Biochem & Mol Biol, ASIP, ASN, ASPET
C1 [McClung, Holly; Margolis, Lee; Murphy, Nancy; Lin, Gregory; Hydren, Jay; Young, Andrew; Pasiakos, Stefan] US Army Res Inst Environm Med, Mil Nutr Div, Natick, MA USA.
[Davis, Betty] US Army Natick Soldier Res Dev & Engn, Combat Feeding Directorate, Natick, MA USA.
RI Hydren, Jay/H-3654-2016
OI Hydren, Jay/0000-0001-9385-8898
NR 0
TC 0
Z9 0
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PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
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J9 FASEB J
JI Faseb J.
PD APR
PY 2015
VL 29
SU 1
MA 742.4
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA CS0BT
UT WOS:000361722702133
ER
PT J
AU Muhie, S
Gautam, A
Chakraborty, N
Hammamieh, R
Meyerhoff, J
Jett, M
AF Muhie, Seid
Gautam, Aarti
Chakraborty, Nabarun
Hammamieh, Rasha
Meyerhoff, James
Jett, Marti
TI Molecular Indicators of Inflammation along Pathological Time-line of
Post-traumatic Stress Disorder
SO FASEB JOURNAL
LA English
DT Meeting Abstract
CT Experimental Biology Meeting
CY MAR 28-APR 01, 2015
CL Boston, MA
SP Amer Assoc Anatomists, Amer Physiol Soc, Amer Soc Biochem & Mol Biol, ASIP, ASN, ASPET
C1 [Muhie, Seid] Frederick Natl Lab Canc Res, Adv Biomed Comp Ctr, Ft Detrick, MD USA.
[Gautam, Aarti; Chakraborty, Nabarun; Meyerhoff, James] Geneva Fdn, Tacoma, WA USA.
[Hammamieh, Rasha; Jett, Marti] US Army, Integrat Syst Biol Program, Ctr Environm Hlth Res, Ft Detrick, MD USA.
NR 0
TC 0
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PU FEDERATION AMER SOC EXP BIOL
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PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
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J9 FASEB J
JI Faseb J.
PD APR
PY 2015
VL 29
SU 1
MA 888.13
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA CS0BT
UT WOS:000361722705074
ER
PT J
AU Paez, R
Romero, M
Dobyns, A
Francis, M
Taylor, M
Longo, L
Wilson, C
Wilson, S
AF Paez, Ricardo
Romero, Monica
Dobyns, Abby
Francis, Michael
Taylor, Mark
Longo, Lawrence
Wilson, Christopher
Wilson, Sean
TI Influence of Maturation on Ca2+ Waveform Modulation by c-AMP and c-GMP
in Pulmonary Arterial Smooth Muscle of Sheep
SO FASEB JOURNAL
LA English
DT Meeting Abstract
CT Experimental Biology Meeting
CY MAR 28-APR 01, 2015
CL Boston, MA
SP Amer Assoc Anatomists, Amer Physiol Soc, Amer Soc Biochem & Mol Biol, ASIP, ASN, ASPET
C1 [Paez, Ricardo; Dobyns, Abby; Longo, Lawrence; Wilson, Christopher; Wilson, Sean] Loma Linda Univ, Sch Med, Ctr Perinatal Biol, Loma Linda, CA USA.
[Romero, Monica; Wilson, Sean] LLUSOM, Adv Imaging & Microscopy Core, Loma Linda, CA USA.
[Francis, Michael; Taylor, Mark] USA, Coll Med, Physiol, Mobile, AL USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
EI 1530-6860
J9 FASEB J
JI Faseb J.
PD APR
PY 2015
VL 29
SU 1
MA 1031.11
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA CS0BT
UT WOS:000361722707457
ER
PT J
AU Pasiakos, S
McClung, H
Murphy, N
Margolis, L
Lin, G
Hydren, J
Davis, B
Young, A
AF Pasiakos, Stefan
McClung, Holly
Murphy, Nancy
Margolis, Lee
Lin, Gregory
Hydren, Jay
Davis, Betty
Young, Andrew
TI Muscle Protein Synthetic Responses to Essential Amino Acid
Supplementation during Load Carriage Exercise
SO FASEB JOURNAL
LA English
DT Meeting Abstract
CT Experimental Biology Meeting
CY MAR 28-APR 01, 2015
CL Boston, MA
SP Amer Assoc Anatomists, Amer Physiol Soc, Amer Soc Biochem & Mol Biol, ASIP, ASN, ASPET
C1 [Pasiakos, Stefan; McClung, Holly; Murphy, Nancy; Margolis, Lee; Lin, Gregory; Hydren, Jay; Young, Andrew] US Army Res Inst Environm Med, Mil Nutr Div, Natick, MA USA.
[Davis, Betty] US Army Natick Soldier Res Dev & Engn Ctr, Combat Feeding Directorate, Natick, MA USA.
RI Hydren, Jay/H-3654-2016
OI Hydren, Jay/0000-0001-9385-8898
NR 0
TC 0
Z9 0
U1 1
U2 1
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
EI 1530-6860
J9 FASEB J
JI Faseb J.
PD APR
PY 2015
VL 29
SU 1
MA 742.3
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA CS0BT
UT WOS:000361722702132
ER
PT J
AU Pierce, L
Kurata, W
Matsumoto, K
Farmer, D
Clark, M
AF Pierce, Lisa
Kurata, Wendy
Matsumoto, Karen
Farmer, Douglas
Clark, Margaret
TI Alterations in Global DNA Methylation/Hydroxymethylation and MicroRNA
Expression in a Rat Model of Gulf War Illness
SO FASEB JOURNAL
LA English
DT Meeting Abstract
CT Experimental Biology Meeting
CY MAR 28-APR 01, 2015
CL Boston, MA
SP Amer Assoc Anatomists, Amer Physiol Soc, Amer Soc Biochem & Mol Biol, ASIP, ASN, ASPET
C1 [Pierce, Lisa; Kurata, Wendy; Matsumoto, Karen; Farmer, Douglas; Clark, Margaret] Tripler Army Med Ctr, Clin Invest, Honolulu, HI 96859 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
EI 1530-6860
J9 FASEB J
JI Faseb J.
PD APR
PY 2015
VL 29
SU 1
MA 814.6
PG 2
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA CS0BT
UT WOS:000361722703217
ER
PT J
AU Quinn, C
Audet, G
Charkoudian, N
Leon, L
AF Quinn, Carrie
Audet, Gerald
Charkoudian, Nisha
Leon, Lisa
TI Cardiovascular Dysregulation during Heat Stroke Recovery in Rats
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [Quinn, Carrie; Audet, Gerald; Charkoudian, Nisha; Leon, Lisa] US Army Res Inst Environm Med, Thermal & Mt Med, Natick, MA USA.
NR 0
TC 0
Z9 0
U1 1
U2 1
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
EI 1530-6860
J9 FASEB J
JI Faseb J.
PD APR
PY 2015
VL 29
SU 1
MA 993.9
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA CS0BT
UT WOS:000361722707216
ER
PT J
AU Smith, T
Wilson, M
Young, A
Montain, S
AF Smith, Tracey
Wilson, Marques
Young, Andrew
Montain, Scott
TI Sleep Restriction Delays Suction Blister Skin Barrier Restoration
SO FASEB JOURNAL
LA English
DT Meeting Abstract
CT Experimental Biology Meeting
CY MAR 28-APR 01, 2015
CL Boston, MA
SP Amer Assoc Anatomists, Amer Physiol Soc, Amer Soc Biochem & Mol Biol, ASIP, ASN, ASPET
C1 [Smith, Tracey; Wilson, Marques; Young, Andrew; Montain, Scott] US Army Res Inst Environm Med, Mil Nutr Div, Natick, MA USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
EI 1530-6860
J9 FASEB J
JI Faseb J.
PD APR
PY 2015
VL 29
SU 1
MA 1037.4
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA CS0BT
UT WOS:000361722708009
ER
PT J
AU Srinivasan, S
Shupp, J
Donohue, D
Hamilton, B
Moffatt, L
Hammamieh, R
Jett, M
AF Srinivasan, Seshamalini
Shupp, Jeffrey
Donohue, Duncan
Hamilton, Brittany
Moffatt, Lauren
Hammamieh, Rasha
Jett, Marti
TI Time-course Characterization of Burn-Induced Coagulopathy using a
Systems Biology Approach
SO FASEB JOURNAL
LA English
DT Meeting Abstract
CT Experimental Biology Meeting
CY MAR 28-APR 01, 2015
CL Boston, MA
SP Amer Assoc Anatomists, Amer Physiol Soc, Amer Soc Biochem & Mol Biol, ASIP, ASN, ASPET
C1 [Srinivasan, Seshamalini; Donohue, Duncan] Geneva Fdn, Integrat Syst Biol, Tacoma, WA 98402 USA.
[Shupp, Jeffrey] Washington Hosp Ctr, Dept Surg, Burn Ctr, MedStar, Washington, DC 20010 USA.
[Shupp, Jeffrey; Hamilton, Brittany; Moffatt, Lauren] MedStar Hlth Res Inst, Firefighters Burn & Surg Res Lab, Washington, DC 20010 USA.
[Hammamieh, Rasha; Jett, Marti] US Army, Ctr Environm Hlth Res, Integrat Syst Biol, Ft Detrick, MD 21702 USA.
NR 0
TC 0
Z9 0
U1 2
U2 2
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
EI 1530-6860
J9 FASEB J
JI Faseb J.
PD APR
PY 2015
VL 29
SU 1
MA 884.61
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA CS0BT
UT WOS:000361722704474
ER
PT J
AU Torres, L
Salgado, C
Valdez, C
Sondeen, J
Dubick, M
Torres, I
AF Torres, Luciana
Salgado, Christi
Valdez, Celina
Sondeen, Jill
Dubick, Michael
Torres Filho, Ivo
TI Protective Function of Endothelial Glycocalyx (EG) during Hemorrhagic
Shock (HS) in Skeletal Muscle: Integration of Systemic and Local
Parameters In Vivo
SO FASEB JOURNAL
LA English
DT Meeting Abstract
CT Experimental Biology Meeting
CY MAR 28-APR 01, 2015
CL Boston, MA
SP Amer Assoc Anatomists, Amer Physiol Soc, Amer Soc Biochem & Mol Biol, ASIP, ASN, ASPET
C1 [Torres, Luciana; Salgado, Christi; Valdez, Celina; Sondeen, Jill; Dubick, Michael; Torres Filho, Ivo] US Army Inst Surg Res, Damage Control Resuscitat, Sam Houston, TX USA.
NR 0
TC 1
Z9 1
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
EI 1530-6860
J9 FASEB J
JI Faseb J.
PD APR
PY 2015
VL 29
SU 1
MA 800.9
PG 2
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA CS0BT
UT WOS:000361722703045
ER
PT J
AU Uyehara, C
Wetstein, P
Ichimura, W
Murata, LA
Sato, A
Hernandez, C
Kajiura, L
AF Uyehara, Catherine
Wetstein, Paul
Ichimura, Wayne
Murata, Lee-Ann
Sato, Aileen
Hernandez, Claudia
Kajiura, Lauren
TI Vasopressin Increases Adrenal Blood Flow in a Pig Model of Hemorrhagic
Shock
SO FASEB JOURNAL
LA English
DT Meeting Abstract
CT Experimental Biology Meeting
CY MAR 28-APR 01, 2015
CL Boston, MA
SP Amer Assoc Anatomists, Amer Physiol Soc, Amer Soc Biochem & Mol Biol, ASIP, ASN, ASPET
C1 [Uyehara, Catherine; Ichimura, Wayne; Murata, Lee-Ann; Sato, Aileen; Hernandez, Claudia; Kajiura, Lauren] Tripler Army Med Ctr, Dept Clin Invest, Honolulu, HI 96859 USA.
[Wetstein, Paul] Tripler Army Med Ctr, Dept Surg, Honolulu, HI 96859 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
EI 1530-6860
J9 FASEB J
JI Faseb J.
PD APR
PY 2015
VL 29
SU 1
MA 968.15
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA CS0BT
UT WOS:000361722706462
ER
PT J
AU Wentz, L
Berry-Caban, C
Eldred, J
Wu, Q
AF Wentz, Laurel
Berry-Caban, Cristobal
Eldred, Jerad
Wu, Qiang
TI Vitamin D Correlation with Testosterone Concentration in US Army Special
Operations Personnel
SO FASEB JOURNAL
LA English
DT Meeting Abstract
CT Experimental Biology Meeting
CY MAR 28-APR 01, 2015
CL Boston, MA
SP Amer Assoc Anatomists, Amer Physiol Soc, Amer Soc Biochem & Mol Biol, ASIP, ASN, ASPET
C1 [Wentz, Laurel; Wu, Qiang] E Carolina Univ, Nutr Sci, Greenville, NC USA.
[Berry-Caban, Cristobal; Eldred, Jerad] Womack Army Med Ctr, Dept Clin Invest, Ft Bragg, NC USA.
NR 0
TC 1
Z9 1
U1 1
U2 1
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
EI 1530-6860
J9 FASEB J
JI Faseb J.
PD APR
PY 2015
VL 29
SU 1
MA 733.5
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA CS0BT
UT WOS:000361722702008
ER
PT J
AU Agarwal, S
Lieberman, H
Fulgoni, V
AF Agarwal, Sanjiv
Lieberman, Harris
Fulgoni, Victor
TI Effects of Moderate Alcohol Intake on Markers of Liver Function in a
Large Representative Sample of the US Population
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [Agarwal, Sanjiv] Nutr NutriSci LLC, East Norriton, PA USA.
[Agarwal, Sanjiv; Fulgoni, Victor] ORISE Oak Ridge Inst Sci & Educ, Belcamp, MD USA.
[Lieberman, Harris] US Army, Environm Med Res Inst, Mil Nutr Div, Natick, MA USA.
[Fulgoni, Victor] Nutr Nutr Impact LLC, Battle Creek, MI USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
EI 1530-6860
J9 FASEB J
JI Faseb J.
PD APR
PY 2015
VL 29
SU 1
MA LB299
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA CR6PV
UT WOS:000361470500297
ER
PT J
AU Bukhari, A
Das, SK
Montain, S
McGraw, S
Lutz, L
Sepowitz, J
Niro, P
Young, A
Roberts, S
AF Bukhari, Asma
Das, Sai Krupa
Montain, Scott
McGraw, Susan
Lutz, Laura
Sepowitz, John
Niro, Philip
Young, Andrew
Roberts, Susan
TI Weight Control Practices in Civilian Dependents of Active Duty Military
Personnel
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [Bukhari, Asma; Montain, Scott; McGraw, Susan; Lutz, Laura; Sepowitz, John; Niro, Philip; Young, Andrew; Roberts, Susan] US Army Res Inst Environm Med, MND, Natick, MA USA.
[Das, Sai Krupa] Tufts Univ, USDA, Energy Metab Lab, JM,HNRCA, Boston, MA 02111 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
EI 1530-6860
J9 FASEB J
JI Faseb J.
PD APR
PY 2015
VL 29
SU 1
MA 595.1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA CR6PV
UT WOS:000361470505061
ER
PT J
AU Darlington, D
Wu, XW
Cap, A
AF Darlington, Daniel
Wu, Xiaowu
Cap, Andrew
TI Coagulopathy after Polytrauma and Hemorrhage in Rats
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [Darlington, Daniel; Wu, Xiaowu; Cap, Andrew] US Army Inst Surg Res, Blood Program, San Antonio, TX USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
EI 1530-6860
J9 FASEB J
JI Faseb J.
PD APR
PY 2015
VL 29
SU 1
MA 641.7
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA CR6PV
UT WOS:000361470505428
ER
PT J
AU Donohue, D
Gautam, A
Ann-Miller, S
Hammamieh, R
Jett, M
AF Donohue, Duncan
Gautam, Aarti
Ann-Miller, Stacy
Hammamieh, Rasha
Jett, Marti
TI Identifying and Correcting RNA Preservation Differences in Human Blood
Samples
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [Donohue, Duncan; Gautam, Aarti; Ann-Miller, Stacy] Geneva Fdn, USACEHR, Tacoma, WA USA.
[Donohue, Duncan; Gautam, Aarti; Ann-Miller, Stacy; Hammamieh, Rasha; Jett, Marti] USACEHR, US Army Med Res & Mat Command, Integrat Syst Biol, Ft Detrick, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
EI 1530-6860
J9 FASEB J
JI Faseb J.
PD APR
PY 2015
VL 29
SU 1
MA 562.20
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA CR6PV
UT WOS:000361470503478
ER
PT J
AU Fulco, C
Dineen, S
Audet, G
Leon, L
AF Fulco, Cameron
Dineen, Shauna
Audet, Gerald
Leon, Lisa
TI Cerebellar HSP70 Remains Elevated During Heat Stroke Recovery despite
Return to Baseline Core Temperature
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [Fulco, Cameron; Dineen, Shauna; Audet, Gerald; Leon, Lisa] US Army Res Inst Environm Med, Thermal Mt Med Div, Natick, MA USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
EI 1530-6860
J9 FASEB J
JI Faseb J.
PD APR
PY 2015
VL 29
SU 1
MA LB673
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA CR6PV
UT WOS:000361470501094
ER
PT J
AU Gaffney-Stomberg, E
Lutz, L
Rood, J
Cable, S
Hughes, J
Pasiakos, S
Young, A
McClung, J
AF Gaffney-Stomberg, Erin
Lutz, Laura
Rood, Jennifer
Cable, Sonya
Hughes, Julie
Pasiakos, Stefan
Young, Andrew
McClung, James
TI Hemoglobin is Positively Associated with Bone Strength in Young Adults
Entering the Military
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [Gaffney-Stomberg, Erin; Lutz, Laura; Hughes, Julie; Pasiakos, Stefan; Young, Andrew; McClung, James] US Army, Environm Med Res Inst, MND MPD, Natick, MA 01760 USA.
[Rood, Jennifer] Pennington Biomed Res Ctr, Baton Rouge, LA 70808 USA.
[Cable, Sonya] Initial Mil Training Ctr Excellence, Ft Eustis, VA USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
EI 1530-6860
J9 FASEB J
JI Faseb J.
PD APR
PY 2015
VL 29
SU 1
MA 263.4
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA CR6PV
UT WOS:000361470502231
ER
PT J
AU Kirkpatrick, M
Sweeney, R
Kasten, S
Ditargiani, R
Cerasoli, D
Otto, T
AF Kirkpatrick, Melanie
Sweeney, Richard
Kasten, Shane
Ditargiani, Robert
Cerasoli, Douglas
Otto, Tamara
TI Use of V-Agent Analogs to Probe the Active Site of Atypical
Butyrylcholinesterase from Oryzias latipes
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [Kirkpatrick, Melanie; Sweeney, Richard; Kasten, Shane; Ditargiani, Robert; Cerasoli, Douglas; Otto, Tamara] US Army, Med Res Inst Chem Def, Res Div, Aberdeen Proving Ground, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
EI 1530-6860
J9 FASEB J
JI Faseb J.
PD APR
PY 2015
VL 29
SU 1
MA 573.6
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA CR6PV
UT WOS:000361470504206
ER
PT J
AU Lieberman, H
Marriott, B
Judelson, D
Glickman, E
Geiselman, P
Giles, G
Mahoney, C
AF Lieberman, Harris
Marriott, Bernadette
Judelson, Daniel
Glickman, Ellen
Geiselman, Paula
Giles, Grace
Mahoney, Caroline
TI Intake of Caffeine from All Sources Including Energy Drinks and Reasons
for Use in US College Students
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [Lieberman, Harris] US Army Res Inst Environm Med, Mil Nutr Div, Natick, MA USA.
[Marriott, Bernadette] Med Univ S Carolina, Dept Med, Charleston, SC 29425 USA.
[Judelson, Daniel] Calif State Univ Fullerton, Dept Kinesiol, Fullerton, CA 92634 USA.
[Glickman, Ellen] Kent State Univ, Dept Exercise Physiol, Kent, OH 44242 USA.
[Geiselman, Paula] Louisiana State Univ, Pennington Biomed Res Ctr, Dept Psychol, Baton Rouge, LA 70808 USA.
[Giles, Grace; Mahoney, Caroline] US Army Natick Soldier RD&E Ctr, Cognit Sci, Natick, MA USA.
NR 0
TC 1
Z9 1
U1 2
U2 10
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
EI 1530-6860
J9 FASEB J
JI Faseb J.
PD APR
PY 2015
VL 29
SU 1
MA 392.1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA CR6PV
UT WOS:000361470503019
ER
PT J
AU Martini, W
Rodriguez, C
Richardson, J
Cap, A
Dubick, M
AF Martini, Wenjun
Rodriguez, Cassandra
Richardson, Jonathan
Cap, Andrew
Dubick, Michael
TI In Vivo Effects of Platelet Apheresis on Oxygen Metabolism in Pigs
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [Martini, Wenjun; Rodriguez, Cassandra; Richardson, Jonathan; Cap, Andrew; Dubick, Michael] US Army Inst Surg Res, Damage Control Dept, Ft Sam Houston, TX USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
EI 1530-6860
J9 FASEB J
JI Faseb J.
PD APR
PY 2015
VL 29
SU 1
MA 641.1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA CR6PV
UT WOS:000361470505422
ER
PT J
AU McClung, J
Gaffney-Stomberg, E
Lutz, L
Rood, J
Cable, S
Pasiakos, S
Young, A
AF McClung, James
Gaffney-Stomberg, Erin
Lutz, Laura
Rood, Jennifer
Cable, Sonya
Pasiakos, Stefan
Young, Andrew
TI Calcium and Vitamin D Supplementation Does Not Affect Iron Status during
Initial Military Training: A Randomized, Double-Blind,
Placebo-Controlled Trial
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [McClung, James; Gaffney-Stomberg, Erin; Lutz, Laura; Pasiakos, Stefan; Young, Andrew] US Army, Environm Med Res Inst, Mil Nutr Div, Natick, MA 01760 USA.
[Rood, Jennifer] Pennington Biomed Res Ctr, Baton Rouge, LA 70808 USA.
[Cable, Sonya] Initial Mil Training Ctr Excellence, Ft Eustis, VA USA.
NR 0
TC 0
Z9 0
U1 0
U2 2
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
EI 1530-6860
J9 FASEB J
JI Faseb J.
PD APR
PY 2015
VL 29
SU 1
MA 263.1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA CR6PV
UT WOS:000361470502228
ER
PT J
AU Montain, S
Johannsen, N
Champagne, C
Marriott, B
Hibbeln, J
Hawes, M
Berry, K
AF Montain, Scott
Johannsen, Neil
Champagne, Catherine
Marriott, Bernadette
Hibbeln, Joseph
Hawes, Michael
Berry, Kevin
TI Influence of Omega-6 HUFA Status on Recovery of Muscle Performance After
Fatiguing Exercise
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [Montain, Scott] US Army, Inst Environm Med, Mil Nutr, Natick, MA 01760 USA.
[Johannsen, Neil; Champagne, Catherine] Pennington Biomed Res Ctr, Dept Nutr, Baton Rouge, LA 70808 USA.
[Marriott, Bernadette] Med Univ S Carolina, Dept Med, Charleston, SC 29425 USA.
[Hibbeln, Joseph] NIAAA, Nutr Neurosci, NIH, Silver Spring, MD USA.
[Hawes, Michael] Owner Belovo Inc, Pinehurst, NC USA.
[Berry, Kevin] Samueli Inst, Mil Med Res, Alexandria, VA USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
EI 1530-6860
J9 FASEB J
JI Faseb J.
PD APR
PY 2015
VL 29
SU 1
MA 598.6
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA CR6PV
UT WOS:000361470505127
ER
PT J
AU Morris, R
Schaffer, B
Lundy, J
Pidcoke, H
Cap, A
Schwacha, M
AF Morris, Rachel
Schaffer, Beverly
Lundy, John
Pidcoke, Heather
Cap, Andrew
Schwacha, Martin
TI Interrelationships Between Platelet Activity and the Immunoinflammatory
Response to Severe Injury
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [Schaffer, Beverly; Lundy, John; Pidcoke, Heather; Cap, Andrew; Schwacha, Martin] US Army Inst Surg Res, Blood Res, Jbsa Ft Sam Houston, TX USA.
[Morris, Rachel; Pidcoke, Heather; Cap, Andrew; Schwacha, Martin] Univ Texas Hlth Sci Ctr San Antonio, Surg, San Antonio, TX 78229 USA.
NR 0
TC 0
Z9 0
U1 2
U2 2
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
EI 1530-6860
J9 FASEB J
JI Faseb J.
PD APR
PY 2015
VL 29
SU 1
MA 641.2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA CR6PV
UT WOS:000361470505423
ER
PT J
AU O'Connor, K
Lieberman, H
Young, A
Montain, S
Scisco, J
Karl, J
AF O'Connor, Kristie
Lieberman, Harris
Young, Andrew
Montain, Scott
Scisco, Jenna
Karl, J.
TI Altered Gut Hormone Secretion Precedes Overeating Following Acute Energy
Deprivation
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [O'Connor, Kristie; Lieberman, Harris; Young, Andrew; Montain, Scott; Scisco, Jenna; Karl, J.] US Army Res Inst Environm Med, MND, Natick, MA USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
EI 1530-6860
J9 FASEB J
JI Faseb J.
PD APR
PY 2015
VL 29
SU 1
MA 594.2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA CR6PV
UT WOS:000361470505049
ER
PT J
AU Shen, C
Romero, M
Brunelle, A
Dobyns, A
Francis, M
Taylor, M
Longo, L
Wilson, C
Wilson, S
AF Shen, Christine
Romero, Monica
Brunelle, Alexander
Dobyns, Abigail
Francis, Michael
Taylor, Mark
Longo, Lawrence
Wilson, Christopher
Wilson, Sean
TI Activation Of L-type Calcium Channels Influences Calcium Waves After
Long-Term Hypoxia And Developmental Maturation
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [Shen, Christine; Brunelle, Alexander; Dobyns, Abigail; Longo, Lawrence; Wilson, Christopher; Wilson, Sean] Loma Linda Univ, Sch Med, Ctr Perinatal Biol, Loma Linda, CA 92350 USA.
[Francis, Michael; Taylor, Mark] USA, Coll Med, Physiol, Washington, DC USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
EI 1530-6860
J9 FASEB J
JI Faseb J.
PD APR
PY 2015
VL 29
SU 1
MA 662.1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA CR6PV
UT WOS:000361470506128
ER
PT J
AU Smith, S
Gregory, J
Zeisel, S
Ueland, P
Gibson, C
Mader, T
Kinchen, J
Ploutz-Snyder, R
Zwart, S
AF Smith, Scott
Gregory, Jesse
Zeisel, Steven
Ueland, Per
Gibson, C.
Mader, Thomas
Kinchen, Jason
Ploutz-Snyder, Robert
Zwart, Sara
TI Vision Issues and Space Flight: Evaluation of One-Carbon Metabolism
Polymorphisms
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [Smith, Scott] NASA, Biomed Res Environ Sci Div, Houston, TX USA.
[Gregory, Jesse] UF, Gainesville, FL USA.
[Zeisel, Steven] UNC, Chapel Hill, NC USA.
[Ueland, Per] Univ Bergen, N-5020 Bergen, Norway.
[Mader, Thomas] US Army, Washington, DC USA.
[Kinchen, Jason] Metabolon, Durham, NC USA.
NR 0
TC 0
Z9 0
U1 1
U2 3
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
EI 1530-6860
J9 FASEB J
JI Faseb J.
PD APR
PY 2015
VL 29
SU 1
MA 134.1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA CR6PV
UT WOS:000361470501477
ER
PT J
AU Wu, XW
Schwacha, M
Dubick, M
Cap, A
Darlington, D
AF Wu, Xiaowu
Schwacha, Martin
Dubick, Michael
Cap, Andrew
Darlington, Daniel
TI Severe Polytrauma Leads to Acute Lung Injury in Rats
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [Wu, Xiaowu; Schwacha, Martin; Dubick, Michael; Cap, Andrew; Darlington, Daniel] US Army Inst Surg Res, Blood Program, San Antonio, TX USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
EI 1530-6860
J9 FASEB J
JI Faseb J.
PD APR
PY 2015
VL 29
SU 1
MA 641.8
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA CR6PV
UT WOS:000361470505429
ER
PT J
AU Stratton, A
Fenderson, J
Kenny, P
Helman, DL
AF Stratton, Amy
Fenderson, Joshua
Kenny, Patrick
Helman, Donald Lee
TI Severe acute hepatitis following intravenous amiodarone : a case report
and review of the literature
SO ACTA GASTRO-ENTEROLOGICA BELGICA
LA English
DT Article
DE amiodarone hepatotoxicity; polysorbate 80; amiodarone hepatitis; severe
acute hepatitis
ID PARENTERAL AMIODARONE; ISCHEMIC HEPATITIS; CAUSALITY ASSESSMENT; ADVERSE
REACTIONS; HEPATOTOXICITY; DRUGS
AB Background and Aims : Hepatotoxic complications of long-term oral amiodarone therapy have been well described; however, liver injury secondary to parenteral infusion of amiodarone is uncommon, potentially fatal, and poorly understood. The hepatotoxicity is thought to result from the diluent polysorbate 80 and not the amiodarone its self. Theories suggest an allergic or immunologic response leading to alterations in the hepatocellular membrane while some propose that ischemia, not a drug reaction, is truly to blame.
Methods : Both the PubMed and Embase databases were searched for cases of acute hepatitis implicating intravenous amiodarone with a total of 25 cases from 1986 to 2012 identified. Each case was then carefully evaluated to determine the connection between parenteral amiodarone and acute hepatotoxicity while assessing for evidence of potential ischemia.
Results : Of the 25 published cases of amiodarone induced acute hepatotoxicity available for review, only 10 provide evidence to conclusively implicate parenteral amiodarone as the etiology. We add the eleventh reported case of parenteral amiodarone induced acute severe hepatitis to the literature and report the most comprehensive review of this topic to date.
Conclusion : There is sufficient evidence to support amiodarone induced acute hepatotoxicity as a unique entity separate from ischemic hepatitis. If suspected, parenteral amiodarone should be discontinued and held indefinitely.
C1 [Stratton, Amy; Fenderson, Joshua; Kenny, Patrick; Helman, Donald Lee] Tripler Army Med Ctr, Dept Internal Med, Honolulu, HI 96859 USA.
[Kenny, Patrick] Tripler Army Med Ctr, Gastroenterol Serv, Honolulu, HI 96859 USA.
[Helman, Donald Lee] Tripler Army Med Ctr, Crit Care & Pulmonol Serv, Honolulu, HI 96859 USA.
RP Stratton, A (reprint author), Tripler Army Med Ctr, DO, 1 Jarrett White Rd, Honolulu, HI 96859 USA.
EM amynstratton@gmail.com
NR 29
TC 1
Z9 1
U1 1
U2 3
PU UNIV CATHOLIQUE LOUVAIN-UCL
PI BRUSSELS
PA CLIN UNIV SAINT LUC, AVE HIPPOCRATE 10, BRUSSELS, B-1200, BELGIUM
SN 0001-5644
J9 ACTA GASTRO-ENT BELG
JI Acta Gastro-Enterol. Belg.
PD APR-JUN
PY 2015
VL 78
IS 2
BP 233
EP 239
PG 7
WC Gastroenterology & Hepatology
SC Gastroenterology & Hepatology
GA CR9EA
UT WOS:000361654800007
PM 26151694
ER
PT J
AU Heston, AH
Schwartz, AL
Justice-Gardiner, H
Hohman, KH
AF Heston, Ann-Hilary
Schwartz, Anna L.
Justice-Gardiner, Haley
Hohman, Katherine H.
TI Addressing Physical Activity Needs of Survivors by Developing a
Community-Based Exercise Program: LIVESTRONG (R) at the YMCA
SO CLINICAL JOURNAL OF ONCOLOGY NURSING
LA English
DT Article
DE exercise; physical activity; LIVESTRONG Foundation; YMCA; community
health services; cancer survivorship
ID CANCER SURVIVORS; GUIDELINES; DIAGNOSIS
AB Background: Although methods of cancer detection and treatment have improved, the side effects of treatment can cause profound debilitation that may linger years after treatment ends. Exercise during and after cancer treatment is safe, and it minimizes many of the deleterious physical and emotional side effects. With this evidence in mind, the LIVESTRONG Foundation and the YMCA of the USA collaborated to develop a community-based physical activity program for survivors, LIVESTRONG (R) at the YMCA.
Objectives: This article provides in-depth information about the development of the LIVESTRONG at the YMCA program and its subsequent spread to meet the physical activity needs of survivors across the country.
Methods: Participating YMCAs engage in regular data collection efforts to track progress on organizational change and program delivery. These efforts include a staff evaluation survey, functional assessment of participants, patient-reported health status assessment, and patient program evaluation.
Findings: From the time of its development, the LIVESTRONG at the YMCA program has served more than 29,000 survivors and trained more than 2,200 LIVESTRONG at the YMCA instructors. A national survey of more than 1,600 program participants demonstrates positive outcomes on health and well-being, as well as intent to continue exercising after the program's end.
C1 [Heston, Ann-Hilary] USA, YMCA, Chron Dis Prevent Programs, Chicago, IL 60606 USA.
[Schwartz, Anna L.] No Arizona Univ, Sch Nursing, Flagstaff, AZ 86011 USA.
[Justice-Gardiner, Haley] March Dimes Texas Chapter, Program Serv, Austin, TX USA.
[Hohman, Katherine H.] USA, YMCA, Qual Improvement, Chicago, IL USA.
RP Heston, AH (reprint author), USA, YMCA, Chron Dis Prevent Programs, Chicago, IL 60606 USA.
EM ann-hilary.heston@ymca.net
NR 16
TC 2
Z9 2
U1 0
U2 2
PU ONCOLOGY NURSING SOC
PI PITTSBURGH
PA 125 ENTERPRISE DR, PITTSBURGH, PA 15275 USA
SN 1092-1095
EI 1538-067X
J9 CLIN J ONCOL NURS
JI Clin. J. Oncol. Nurs.
PD APR
PY 2015
VL 19
IS 2
BP 213
EP 217
DI 10.1188/15.CJON.213-217
PG 5
WC Oncology; Nursing
SC Oncology; Nursing
GA CF3LI
UT WOS:000352449700019
PM 25840387
ER
PT J
AU Wu, J
Yu, P
Susha, AS
Sablon, KA
Chen, HY
Zhou, ZH
Li, HD
Ji, HN
Niu, XB
Govorov, AO
Rogach, AL
Wang, ZMM
AF Wu, Jiang
Yu, Peng
Susha, Andrei S.
Sablon, Kimberly A.
Chen, Haiyuan
Zhou, Zhihua
Li, Handong
Ji, Haining
Niu, Xiaobin
Govorov, Alexander O.
Rogach, Andrey L.
Wang, Zhiming M.
TI Broadband efficiency enhancement in quantum dot solar cells coupled with
multispiked plasmonic nanostars
SO NANO ENERGY
LA English
DT Article
DE Surface plasmon; Nanoparticles; Noble metals; Solar cells; Quantum dots
ID GOLD NANOPARTICLES; OPTICAL-PROPERTIES; AG; TRANSITIONS; GRAPHENE; SIZE
AB We report a significant broadband enhancement of the external quantum efficiency of the quantum dot solar cell by coupling with plasmonic nanostars via a simple and scalable "boiling deposition" technique. The multispiked nanostars provide broadband scattering and absorption cross-sections, which can be engineered to dramatically boost the performance of the solar cells. The localized near field modes of nanostars result in an external quantum efficiency enhancement over 400% for short-wavelength light absorbed in the emitter, while plasmon light scattering causes distinct improvement in quantum efficiency (10-50%) in the long-wavelength region up to 1100 nm. Finite difference time domain method is adopted to explain the origin of the optical absorption enhancement in the quantum dot solar cells. The broadband light concentration by plasmonic nanostars can significantly reduce the amount of quantum dot materials required for a solar cell and provide efficient utilization of the full solar spectrum. (C) 2015 Elsevier Ltd. All rights reserved.
C1 [Wu, Jiang; Yu, Peng; Chen, Haiyuan; Zhou, Zhihua; Li, Handong; Ji, Haining; Niu, Xiaobin; Wang, Zhiming M.] Univ Elect Sci & Technol China, Inst Fundamental & Frontier Sci, Chengdu 610054, Peoples R China.
[Wu, Jiang; Zhou, Zhihua; Li, Handong; Ji, Haining; Niu, Xiaobin; Wang, Zhiming M.] Univ Elect Sci & Technol China, State Key Lab Elect Thin Films & Integrated Devic, Chengdu 610054, Peoples R China.
[Wu, Jiang] UCL, Dept Elect & Elect Engn, London WC1E 7JE, England.
[Susha, Andrei S.; Rogach, Andrey L.] City Univ Hong Kong, Dept Phys & Mat Sci, Hong Kong, Hong Kong, Peoples R China.
[Sablon, Kimberly A.] US Army, Res Lab, Adelphi, MD 20783 USA.
[Govorov, Alexander O.] Ohio Univ, Dept Phys & Astron, Athens, OH 45701 USA.
RP Wang, ZMM (reprint author), Univ Elect Sci & Technol China, Inst Fundamental & Frontier Sci, Chengdu 610054, Peoples R China.
EM zhmwang@uestc.edu.cn
RI Wang, Zhiming/Q-1031-2015; Li, Handong/J-5225-2015; Zhou,
Zhihua/B-7290-2009
OI Zhou, Zhihua/0000-0001-5014-6946
FU Specialized Research Fund for the Doctoral Program of Higher Education
(SRFDP); Research Grants Council Earmarked Research Grants (RGC-ERG)
[M_CityU 102/12]; National Natural Science Foundation of China
[NSFC-61474015]; Fundamental Research Funds for Central Universities
[ZYGX2012J034]
FX J. Wu and P. Yu contributed equally to this work. This work was
supported by the Specialized Research Fund for the Doctoral Program of
Higher Education (SRFDP) and Research Grants Council Earmarked Research
Grants (RGC-ERG) under the Grant M_CityU 102/12, the National Natural
Science Foundation of China through Grant NSFC-61474015, and the
Fundamental Research Funds for Central Universities under the Grant
ZYGX2012J034.
NR 34
TC 21
Z9 21
U1 4
U2 50
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 2211-2855
EI 2211-3282
J9 NANO ENERGY
JI Nano Energy
PD APR
PY 2015
VL 13
BP 827
EP 835
DI 10.1016/j.nanoen.2015.02.012
PG 9
WC Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science,
Multidisciplinary; Physics, Applied
SC Chemistry; Science & Technology - Other Topics; Materials Science;
Physics
GA CN4QI
UT WOS:000358414700084
ER
PT J
AU Netherland, MD
Jones, D
AF Netherland, Michael D.
Jones, Dean
TI Fluridone-Resistant Hydrilla (Hydrilla verticillata) Is Still Dominant
in the Kissimmee Chain of Lakes, FL
SO INVASIVE PLANT SCIENCE AND MANAGEMENT
LA English
DT Article
DE Aquatic herbicide; invasive aquatic plant; submersed aquatic vegetation
ID EURASIAN WATERMILFOIL; PHYTOENE DESATURASE; HERBICIDE RESISTANCE;
ECOLOGICAL FITNESS; FLORIDA; MANAGEMENT; EVOLUTION; SENSITIVITY;
NORFLURAZON; POPULATION
AB The invasive aquatic plant hydrilla rapidly spread through the 28,500 ha Kissimmee Chain of Lakes (KCOL) system in Florida in the late 1980s and early 1990s. Large-scale herbicide treatments with fluridone were initiated in 1993 and resulted in widespread reduction in hydrilla; however, by 2000, sustained use of fluridone resulted in dominance of fluridone-resistant strains of hydrilla throughout these lakes. The last large-scale fluridone applications on the KCOL were conducted in 2004, and in 2012, a sampling effort was initiated to determine the status of fluridone-resistant strains of hydrilla given an 8-yr period with no further selection pressure from fluridone. A total of 260 sites were sampled on the lakes during March, May, September, and December 2012. Plants were returned to the lab and exposed to fluridone at concentrations of 5, 10, and 20 mu g L-1 and a pulse-amplitude-modulated (PAM) fluorometer was utilized to measure fluorescence yield of new shoot tissue growth following a 14-d exposure period. Results indicate that 80 to 90% of the sites sampled on the four lakes of the Kissimmee Chain remain resistant to fluridone. Three distinct patterns of response to fluridone were noted, suggesting that susceptible, moderately tolerant, and highly tolerant strains of hydrilla currently coexist on these lakes. Although fluridone-susceptible plants were present on the KCOL, this study clearly demonstrates that most of the hydrilla remained resistant despite an 8-yr period with no fluridone selection pressure.
C1 [Netherland, Michael D.] US Army, Engn Res & Dev Ctr, Ctr Aquat & Invas Plants, Gainesville, FL 32653 USA.
[Jones, Dean] Univ Florida, Ctr Aquat & Invas Plants, Lake Alfred, FL 33850 USA.
RP Netherland, MD (reprint author), US Army, Engn Res & Dev Ctr, Ctr Aquat & Invas Plants, Gainesville, FL 32653 USA.
EM mdnether@ufl.edu
FU U.S. Army Engineer Aquatic Plant Control Research Program; Environmental
Protection Agency, Osceola County Demonstration Project on Hydrilla and
Hygrophila in the Upper Kissimmee Chain of Lakes, FL [X796433105];
Florida Fish and Wildlife Commission; Bureau of Invasive Plant
Management
FX Support and funding for this project was provided by the U.S. Army
Engineer Aquatic Plant Control Research Program; the Environmental
Protection Agency as part of the Osceola County Demonstration Project on
Hydrilla and Hygrophila in the Upper Kissimmee Chain of Lakes, FL. (EPA
Grant ID: X796433105); and the Florida Fish and Wildlife Commission,
Bureau of Invasive Plant Management. Permission was granted by the Chief
of Engineers to publish this research. The authors thank Erin Canter for
assistance in field collections and laboratory support.
NR 27
TC 1
Z9 1
U1 5
U2 21
PU WEED SCI SOC AMER
PI LAWRENCE
PA 810 EAST 10TH ST, LAWRENCE, KS 66044-8897 USA
SN 1939-7291
EI 1939-747X
J9 INVAS PLANT SCI MANA
JI Invasive Plant Sci. Manag.
PD APR-JUN
PY 2015
VL 8
IS 2
BP 212
EP 218
DI 10.1614/IPSM-D-14-00071.1
PG 7
WC Plant Sciences
SC Plant Sciences
GA CM8HU
UT WOS:000357940900011
ER
PT J
AU Palmqvist, A
Baker, L
Forbes, VE
Gergs, A
von der Kammer, F
Luoma, S
Lutzhoft, HCH
Salinas, E
Sorensen, M
Steevens, J
AF Palmqvist, Annemette
Baker, Leanne
Forbes, Valery E.
Gergs, Andre
von der Kammer, Frank
Luoma, Samuel
Lutzhoft, Hans Christian Holten
Salinas, Edward
Sorensen, Mary
Steevens, Jeffery
TI NANOMATERIAL ENVIRONMENTAL RISK ASSESSMENT
SO INTEGRATED ENVIRONMENTAL ASSESSMENT AND MANAGEMENT
LA English
DT Editorial Material
C1 [Palmqvist, Annemette] Roskilde Univ, Roskilde, Denmark.
[Baker, Leanne] Baylor Univ, Waco, TX 76798 USA.
[Forbes, Valery E.] Univ Nebraska, Lincoln, NE USA.
[Gergs, Andre] Rhein Westfal TH Aachen, Aachen, Germany.
[von der Kammer, Frank] Univ Vienna, A-1010 Vienna, Austria.
[Luoma, Samuel] Univ Calif Davis, Davis, CA 95616 USA.
[Lutzhoft, Hans Christian Holten] Tech Univ Denmark, DK-2800 Lyngby, Denmark.
[Salinas, Edward] BASF SE, Ludwigshafen, Germany.
[Sorensen, Mary] ENVIRON Int Corp, Atlanta, GA USA.
[Steevens, Jeffery] US Army Engineer Res & Dev Ctr, Vicksburg, MS USA.
RP Palmqvist, A (reprint author), Roskilde Univ, Roskilde, Denmark.
EM apalm@ruc.dk
OI Palmqvist, Annemette/0000-0003-3422-0063; Forbes,
Valery/0000-0001-9819-9385
NR 0
TC 2
Z9 2
U1 0
U2 10
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1551-3777
EI 1551-3793
J9 INTEGR ENVIRON ASSES
JI Integr. Environ. Assess. Manag.
PD APR
PY 2015
VL 11
IS 2
BP 333
EP 335
DI 10.1002/ieam.1625
PG 3
WC Environmental Sciences; Toxicology
SC Environmental Sciences & Ecology; Toxicology
GA CL5SG
UT WOS:000357020200020
PM 25820312
ER
PT J
AU Lee, BB
Baumgartner, I
Berlien, P
Bianchini, G
Burrows, P
Gloviczki, P
Huang, Y
Laredo, J
Loose, DA
Markovic, J
Mattassi, R
Parsi, K
Rabe, E
Rosenblatt, M
Shortell, C
Stillo, F
Vaghi, M
Villavicencio, L
Zamboni, P
AF Lee, B. B.
Baumgartner, I.
Berlien, P.
Bianchini, G.
Burrows, P.
Gloviczki, P.
Huang, Y.
Laredo, J.
Loose, D. A.
Markovic, J.
Mattassi, R.
Parsi, K.
Rabe, E.
Rosenblatt, M.
Shortell, C.
Stillo, F.
Vaghi, M.
Villavicencio, L.
Zamboni, P.
TI Diagnosis and Treatment of Venous Malformations Consensus Document of
the International Union of Phlebology (IUP): updated 2013
SO INTERNATIONAL ANGIOLOGY
LA English
DT Article
DE Venous malformations; ISSVA Classification; Hamburg classification
extratruncular and truncular types; Angiographic classification;
Hemolymphatic malformation; Congenital vascular bone syndrome; Marginal
vein; Multidisciplinary approach
ID CONGENITAL VASCULAR MALFORMATIONS; KLIPPEL-TRENAUNAY-SYNDROME; INFERIOR
VENA-CAVA; BUDD-CHIARI-SYNDROME; OF-THE-LITERATURE; ARTERIOVENOUS
SHUNTING MALFORMATION; PULMONARY ARTERIAL-HYPERTENSION; SODIUM
TETRADECYL SULFATE; KASABACH-MERRITT-SYNDROME; ENDOTHELIAL GROWTH-FACTOR
AB Venous malformations (VMs) are the most common vascular developmental anomalies (birth defects). These defects are caused by developmental arrest of the venous system during various stages of embryogenesis. VMs remain a difficult diagnostic and therapeutic challenge due to the wide range of clinical presentations, unpredictable clinical course, erratic response to the. treatment with high recurrence/persistence rates, high morbidity following non-specific conventional treatment, and confusing terminology The Consensus Panel reviewed the recent scientific literature up to the year 2013 to update a previous IUP Consensus (2009) on the same subject. ISSVA Classification with special merits for the differentiation between the congenital vascular malformation (CVM) and vascular tumors was reinforced with an additional review on syndrome-based classification. A "modified" Hamburg classification was adopted to emphasize the importance of extratruncular vs. truncular sub-types of VMs. This incorporated the embryological origin, morphological differences, unique characteristics, prognosis and recurrence rates of VMs based on this embryological classification. The definition and classification of VMs were strengthened with the addition of angiographic data that determines the hemodynamic characteristics, the anatomical pattern of draining veins and hence the risk of complication following sclerotherapy. The hemolymphatic malformations, a combined condition incorporating LMs and other CVMs, were illustrated as a separate topic to differentiate from isolated VMs and to rectify the existing confusion with name-based eponyms such as Klippel-Trenaunay syndrome. Contemporary concepts on VMs were updated with new data including genetic findings linked to the etiology of CVMs and chronic cerebrospinal venous insufficiency. Besides, newly established information on co-agulopathy including the role of D-Dimer was thoroughly reviewed to provide guidelines on investigations and anticoagulation therapy in the management of VMs. Congenital vascular bone syndrome resulting in angio-osteo-hyper/hypotrophy and (lateral) marginal vein was separately reviewed. Background data on arterio-venous malformations was included to differentiate this anomaly from syndrome-based VMs. For the treatment, a new section on laser therapy and also a practical guideline for follow up assessment were added to strengthen the management principle of the multidisciplinary approach. All other therapeutic modalities were thoroughly updated to accommodate a changing concept through the years.
C1 [Lee, B. B.; Laredo, J.] George Washington Univ, Sch Med, Surg, Washington, DC 20037 USA.
[Lee, B. B.; Laredo, J.] George Washington Univ, Sch Med, Dept Surg, Ctr Vein Lymphat & Vasc Malformat,Div Vasc Surg, Washington, DC 20037 USA.
[Markovic, J.; Shortell, C.] Duke Univ, Med Ctr, Div Vasc Surg, Durham, NC USA.
[Berlien, P.] Evangel Elisabeth Klin, Laser & Surg, Berlin, Germany.
[Berlien, P.] Evangel Elisabeth Klin, Dept Lasermed, Berlin, Germany.
[Bianchini, G.; Stillo, F.] IDI Hosp, Div Vasc Surg, Ctr Vasc Anomalies, Rome, Italy.
[Burrows, P.] Med Coll Wisconsin, Radiol, Milwaukee, WI 53226 USA.
[Burrows, P.] Childrens Hosp Wisconsin, Pediat Vasc Intervent, Milwaukee, WI 53201 USA.
[Gloviczki, P.] Mayo Clin, Coll Med, Surg, Rochester, MN USA.
[Gloviczki, P.] Mayo Clin, Div Vasc & Endovasc Surg, Rochester, MN USA.
[Gloviczki, P.] Mayo Clin, Gonda Vasc Ctr, Rochester, MN USA.
[Baumgartner, I.] Univ Hosp Bern, Inselspital, Div Angiol, Swiss Cardiovasc Ctr, Bern, Switzerland.
[Loose, D. A.] Die Facharztklin Hamburg, European Ctr Diag & Treatment Vasc Malformat, Dept Angiol & Vasc Surg, Hamburg, Germany.
[Mattassi, R.] Clin Inst Humanitas Mater Domini, Vasc Surg, Castellanza, Varese, Italy.
[Mattassi, R.] Clin Inst Humanitas Mater Domini, Ctr Vasc Malformat Stefan Belov, Castellanza, Varese, Italy.
[Parsi, K.] St Vincents Hosp, Dept Dermatol, Sydney, NSW 2010, Australia.
[Parsi, K.] Univ New S Wales, St Vincents Ctr Appl Med Res, Dermatol Phlebol & Fluid Mech Res Program, Sydney, NSW, Australia.
[Stillo, F.] IDI Hosp, Vasc Surg, Rome, Italy.
[Rabe, E.] Univ Bonn, Dept Dermatol, Dermatol Phlebol & Dermatol Angiol, D-53105 Bonn, Germany.
[Rosenblatt, M.] Connecticut Image Guided Surg, Fairfield, CT USA.
[Shortell, C.] Duke Univ, Med Ctr, Vasc Residency, Durham, NC USA.
[Shortell, C.] Duke Univ, Med Ctr, Dept Surg, Durham, NC 27710 USA.
[Vaghi, M.] Hosp G Salvini, Dept Vasc Surg, Garbagnate Milanese, Italy.
[Villavicencio, L.] Uniformed Serv Univ Hlth Sci, Dept Surg, Surg, Bethesda, MD 20814 USA.
[Villavicencio, L.] Walter Reed Army Med Ctr, Venous & Lymphat Teaching Clin, Bethesda, MD USA.
[Huang, Y.] Mayo Clin, Div Vasc & Endovasc Surg, Rochester, MN USA.
[Zamboni, P.] Univ Ferrara, Surg, I-44100 Ferrara, Italy.
[Zamboni, P.] Univ Ferrara, Vasc Dis Ctr, I-44100 Ferrara, Italy.
RP Lee, BB (reprint author), George Washington Univ, Sch Med, Surg, 22nd & I St NW,6th Floor, Washington, DC 20037 USA.
NR 368
TC 14
Z9 16
U1 0
U2 5
PU EDIZIONI MINERVA MEDICA
PI TURIN
PA CORSO BRAMANTE 83-85 INT JOURNALS DEPT., 10126 TURIN, ITALY
SN 0392-9590
EI 1827-1839
J9 INT ANGIOL
JI Int. Angiol.
PD APR
PY 2015
VL 34
IS 2
BP 97
EP 149
PG 53
WC Peripheral Vascular Disease
SC Cardiovascular System & Cardiology
GA CM0FQ
UT WOS:000357354200001
PM 24566499
ER
PT J
AU Heine, HS
Hershfield, J
Marchand, C
Miller, L
Halasohoris, S
Purcell, BK
Worsham, PL
AF Heine, Henry S.
Hershfield, Jeremy
Marchand, Charles
Miller, Lynda
Halasohoris, Stephanie
Purcell, Bret K.
Worsham, Patricia L.
TI In Vitro Antibiotic Susceptibilities of Yersinia pestis Determined by
Broth Microdilution following CLSI Methods
SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
LA English
DT Article
ID ANTIMICROBIAL AGENTS; PLAGUE; RESISTANCE; PLASMIDS
AB In vitro susceptibilities to 45 antibiotics were determined for 30 genetically and geographically diverse strains of Yersinia pestis by the broth microdilution method at two temperatures, 28 degrees C and 35 degrees C, following Clinical and Laboratory Standards Institute (CLSI) methods. The Y. pestis strains demonstrated susceptibility to aminoglycosides, quinolones, tetracyclines, beta-lactams, cephalosporins, and carbapenems. Only a 1-well shift was observed for the majority of antibiotics between the two temperatures. Establishing and comparing antibiotic susceptibilities of a diverse but specific set of Y. pestis strains by standardized methods and establishing population ranges and MIC50 and MIC90 values provide reference information for assessing new antibiotic agents and also provide a baseline for use in monitoring any future emergence of resistance.
C1 [Heine, Henry S.; Hershfield, Jeremy; Marchand, Charles; Miller, Lynda; Halasohoris, Stephanie; Purcell, Bret K.; Worsham, Patricia L.] US Army Med Res Inst Infect Dis, Bacteriol Div, Ft Detrick, MD USA.
RP Heine, HS (reprint author), Univ Florida, Coll Med, Dept Med, Inst Therapeut Innovat, Orlando, FL 32816 USA.
EM henry.heine@medicine.ufl.edu
FU Defense Threat Reduction Agency [02-4-2C-013]
FX The research described herein was sponsored by the Defense Threat
Reduction Agency project no. 02-4-2C-013.
NR 19
TC 1
Z9 1
U1 0
U2 6
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0066-4804
EI 1098-6596
J9 ANTIMICROB AGENTS CH
JI Antimicrob. Agents Chemother.
PD APR
PY 2015
VL 59
IS 4
BP 1919
EP 1921
DI 10.1128/AAC.04548-14
PG 3
WC Microbiology; Pharmacology & Pharmacy
SC Microbiology; Pharmacology & Pharmacy
GA CI8BY
UT WOS:000354993700012
PM 25583720
ER
PT J
AU Biron, B
Beck, K
Dyer, D
Mattix, M
Twenhafel, N
Nalca, A
AF Biron, Bethany
Beck, Katie
Dyer, David
Mattix, Marc
Twenhafel, Nancy
Nalca, Aysegul
TI Efficacy of ETI-204 Monoclonal Antibody as an Adjunct Therapy in a New
Zealand White Rabbit Partial Survival Model for Inhalational Anthrax
SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
LA English
DT Article
ID PROTECTIVE ANTIGEN; BACILLUS-ANTHRACIS; POSTEXPOSURE PROPHYLAXIS;
ANIMAL-MODELS; BIOLOGICAL WEAPON; UNITED-STATES; PATHOLOGY;
PATHOGENESIS; INFECTION; TOXIN
AB Inhalational anthrax is characterized by extensive bacteremia and toxemia as well as nonspecific to mild flu-like symptoms, until the onset of hypotension, shock, and mortality. Without treatment, the mortality rate approaches 100%. Antibiotic treatment is not always effective, and alternative treatments are needed, such as monotherapy for antibiotic-resistant inhalational anthrax or as an adjunct therapy in combination with antibiotics. The Bacillus anthracis antitoxin monoclonal antibody (MAb) ETI-204 is a high-affinity chimeric deimmunized antibody which targets the anthrax toxin protective antigen (PA). In this study, a partial protection New Zealand White (NZW) rabbit model was used to evaluate the protective efficacy of the adjunct therapy with the MAb. Following detection of PA in the blood, NZW rabbits were administered either an antibiotic (doxycycline) alone or the antibiotic in conjunction with ETI-204. Survival was evaluated to compare the efficacy of the combination adjunct therapy with that of an antibiotic alone in treating inhalational anthrax. Overall, the results from this study indicate that a subtherapeutic regimen consisting of an antibiotic in combination with an anti-PA MAb results in increased survival compared to the antibiotic alone and would provide an effective therapeutic strategy against symptomatic anthrax in nonvaccinated individuals.
C1 [Biron, Bethany; Beck, Katie; Dyer, David; Nalca, Aysegul] US Army, Med Res Inst Infect Dis, Ctr Aerobiol Sci, Ft Detrick, MD 21702 USA.
[Mattix, Marc; Twenhafel, Nancy] US Army, Med Res Inst Infect Dis, Div Pathol, Ft Detrick, MD 21702 USA.
RP Nalca, A (reprint author), US Army, Med Res Inst Infect Dis, Ctr Aerobiol Sci, Ft Detrick, MD 21702 USA.
EM aysegul.nalca@us.army.mil
FU Office of Biodefense, Research Resources and Translational Research;
National Institute of Allergy and Infectious Diseases; USAMRIID
FX This study was supported by an interagency agreement between the Office
of Biodefense, Research Resources and Translational Research, National
Institute of Allergy and Infectious Diseases, and USAMRIID.
NR 57
TC 5
Z9 5
U1 1
U2 3
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0066-4804
EI 1098-6596
J9 ANTIMICROB AGENTS CH
JI Antimicrob. Agents Chemother.
PD APR
PY 2015
VL 59
IS 4
BP 2206
EP 2214
DI 10.1128/AAC.04593-14
PG 9
WC Microbiology; Pharmacology & Pharmacy
SC Microbiology; Pharmacology & Pharmacy
GA CI8BY
UT WOS:000354993700046
PM 25645849
ER
PT J
AU Waag, DM
AF Waag, David M.
TI Efficacy of Postexposure Therapy against Glanders in Mice
SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
LA English
DT Article
ID BURKHOLDERIA-MALLEI; EXPERIMENTAL MELIOIDOSIS; BALB/C MICE;
PSEUDOMALLEI; SUSCEPTIBILITIES; AGENT
AB Burkholderia mallei, the causative agent of glanders, is a CDC Tier 1 Select Agent for which there is no preventive vaccine and antibiotic therapy is difficult. In this study, we show that a combination of vaccination using killed cellular vaccine and therapy using moxifloxacin, azithromycin, or sulfamethoxazole-trimethoprim can protect BALB/c mice from lethal infection even when given 5 days after infectious challenge. Vaccination only, or antibiotic therapy only, was not efficacious. Although antibiotics evaluated experimentally can protect when given before or 1 day after challenge, this time course is not realistic in the cases of natural infection or biological attack, when the patient seeks treatment after symptoms develop or after a biological attack has been confirmed and the agent has been identified. Antibiotics can be efficacious after a prolonged interval between exposure and treatment, but only if the animals were previously vaccinated.
C1 US Army, Med Res Inst Infect Dis, Bacteriol Div, Ft Detrick, MD 21702 USA.
RP Waag, DM (reprint author), US Army, Med Res Inst Infect Dis, Bacteriol Div, Ft Detrick, MD 21702 USA.
EM david.m.waag.ctr@mail.mil
FU Defense Threat Reduction Agency under USAMRIID project [923678]
FX This research was funded by the Defense Threat Reduction Agency under
USAMRIID project number 923678.
NR 24
TC 0
Z9 0
U1 1
U2 2
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0066-4804
EI 1098-6596
J9 ANTIMICROB AGENTS CH
JI Antimicrob. Agents Chemother.
PD APR
PY 2015
VL 59
IS 4
BP 2236
EP 2241
DI 10.1128/AAC.04801-14
PG 6
WC Microbiology; Pharmacology & Pharmacy
SC Microbiology; Pharmacology & Pharmacy
GA CI8BY
UT WOS:000354993700049
PM 25645854
ER
PT J
AU Potter, BMJ
Xie, LH
Vuong, C
Zhang, J
Zhang, P
Duan, DH
Luong, TLT
Herath, HMTB
Nanayakkara, NPD
Tekwani, BL
Walker, LA
Nolan, CK
Sciotti, RJ
Zottig, VE
Smith, PL
Paris, RM
Read, LT
Li, QG
Pybus, BS
Sousa, JC
Reichard, GA
Marcsisin, SR
AF Potter, Brittney M. J.
Xie, Lisa H.
Vuong, Chau
Zhang, Jing
Zhang, Ping
Duan, Dehui
Luong, Thu-Lan T.
Herath, H. M. T. Bandara
Nanayakkara, N. P. Dhammika
Tekwani, Babu L.
Walker, Larry A.
Nolan, Christina K.
Sciotti, Richard J.
Zottig, Victor E.
Smith, Philip L.
Paris, Robert M.
Read, Lisa T.
Li, Qigui
Pybus, Brandon S.
Sousa, Jason C.
Reichard, Gregory A.
Marcsisin, Sean R.
TI Differential CYP 2D6 Metabolism Alters Primaquine Pharmacokinetics
SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
LA English
DT Article
ID ANTIMALARIAL-DRUG PRIMAQUINE; HUMAN CYTOCHROME-P450 2D6;
PLASMODIUM-VIVAX MALARIA; GENETIC POLYMORPHISMS; RAT ERYTHROCYTES;
5-HYDROXYPRIMAQUINE; 8-AMINOQUINOLINE; TRANSMISSION; TAFENOQUINE
AB Primaquine (PQ) metabolism by the cytochrome P450 (CYP) 2D family of enzymes is required for antimalarial activity in both humans (2D6) and mice (2D). Human CYP 2D6 is highly polymorphic, and decreased CYP 2D6 enzyme activity has been linked to decreased PQ antimalarial activity. Despite the importance of CYP 2D metabolism in PQ efficacy, the exact role that these enzymes play in PQ metabolism and pharmacokinetics has not been extensively studied in vivo. In this study, a series of PQ pharmacokinetic experiments were conducted in mice with differential CYP 2D metabolism characteristics, including wild-type (WT), CYP 2D knockout (KO), and humanized CYP 2D6 (KO/knock-in [KO/KI]) mice. Plasma and liver pharmacokinetic profiles from a single PQ dose (20 mg/kg of body weight) differed significantly among the strains for PQ and carboxy-PQ. Additionally, due to the suspected role of phenolic metabolites in PQ efficacy, these were probed using reference standards. Levels of phenolic metabolites were highest in mice capable of metabolizing CYP 2D6 substrates (WT and KO/KI 2D6 mice). PQ phenolic metabolites were present in different quantities in the two strains, illustrating species-specific differences in PQ metabolism between the human and mouse enzymes. Taking the data together, this report furthers understanding of PQ pharmacokinetics in the context of differential CYP 2D metabolism and has important implications for PQ administration in humans with different levels of CYP 2D6 enzyme activity.
C1 [Potter, Brittney M. J.; Xie, Lisa H.; Vuong, Chau; Zhang, Jing; Zhang, Ping; Duan, Dehui; Luong, Thu-Lan T.; Nolan, Christina K.; Sciotti, Richard J.; Zottig, Victor E.; Smith, Philip L.; Paris, Robert M.; Read, Lisa T.; Li, Qigui; Pybus, Brandon S.; Sousa, Jason C.; Reichard, Gregory A.; Marcsisin, Sean R.] Walter Reed Army Inst Res, Div Expt Therapeut, Mil Malaria Res Program, Silver Spring, MD 20910 USA.
[Herath, H. M. T. Bandara; Nanayakkara, N. P. Dhammika; Tekwani, Babu L.; Walker, Larry A.] Univ Mississippi, Natl Ctr Nat Prod Res, University, MS 38677 USA.
[Tekwani, Babu L.; Walker, Larry A.] Univ Mississippi, Sch Pharm, Dept Pharmacol, University, MS 38677 USA.
RP Marcsisin, SR (reprint author), Walter Reed Army Inst Res, Div Expt Therapeut, Mil Malaria Res Program, Silver Spring, MD 20910 USA.
EM sean.r.marcsisin.mil@mail.mil
FU Joint Warfighter Medical Research Program (JWMRP) [W81XWH1020059,
W81XWH1320026]; Military Infectious Diseases Research Program (MIDRP)
[Q0302_12_WR_CS]
FX This work was supported in part by the Joint Warfighter Medical Research
Program (JWMRP), award no. W81XWH1020059 and W81XWH1320026, and the
Military Infectious Diseases Research Program (MIDRP), project no.
Q0302_12_WR_CS.
NR 27
TC 16
Z9 16
U1 3
U2 11
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0066-4804
EI 1098-6596
J9 ANTIMICROB AGENTS CH
JI Antimicrob. Agents Chemother.
PD APR
PY 2015
VL 59
IS 4
BP 2380
EP 2387
DI 10.1128/AAC.00015-15
PG 8
WC Microbiology; Pharmacology & Pharmacy
SC Microbiology; Pharmacology & Pharmacy
GA CI8BY
UT WOS:000354993700066
PM 25645856
ER
PT J
AU Chamok, NH
Anthony, TK
Weiss, SJ
Ali, M
AF Chamok, Nowrin Hasan
Anthony, Theodore K.
Weiss, Steven J.
Ali, Mohammod
TI Ultrathin UHF Broadband Antenna on a Nonuniform Aperiodic Metasurface
SO IEEE ANTENNAS AND PROPAGATION MAGAZINE
LA English
DT Article
DE Broadband antenna; electromagnetic band gap (EBG); metamaterial;
nonuniform aperiodic (NUA) metasurface
ID EBG GROUND PLANE; DIPOLE ANTENNA; PATCH ANTENNAS; IMPEDANCE; SURFACES;
GAP; SUBSTRATE; BANDWIDTH; DESIGN
AB A new concept to design ultrathin directional broadband antennas using a nonuniform aperiodic metasurface is introduced. The study and design of the NUA metasurface show that, by employing a decreasing taper for both the metasurface patch and their interelement spacing, broad impedance and pattern bandwidths can be attained. Experimental results show that, with a total thickness of 0.04 of the free space wavelength (corresponding to the lowest frequency of operation), an octave bandwidth can be attained, which is significantly larger compared with existing designs on uniform mushroom electromagnetic band-gap structures.
C1 [Chamok, Nowrin Hasan; Ali, Mohammod] Univ S Carolina, Dept Elect Engn, Columbia, SC 29208 USA.
[Anthony, Theodore K.; Weiss, Steven J.] Army Res Lab, Adelphi, MD 20783 USA.
RP Chamok, NH (reprint author), Univ S Carolina, Dept Elect Engn, Columbia, SC 29208 USA.
EM chamok@email.sc.edu; theodore.k.anthony.civ@mail.mil;
steven.j.weiss14.civ@mail.mil; alimo@cec.sc.edu
FU Army Research Office (ARO) [W911NF-12-1-0138]
FX This work was supported in part by the Army Research Office (ARO) under
Grant # W911NF-12-1-0138.
NR 50
TC 3
Z9 3
U1 2
U2 14
PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
PI PISCATAWAY
PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA
SN 1045-9243
EI 1558-4143
J9 IEEE ANTENN PROPAG M
JI IEEE Antennas Propag. Mag.
PD APR
PY 2015
VL 57
IS 2
BP 167
EP 180
DI 10.1109/MAP.2015.2414491
PG 14
WC Engineering, Electrical & Electronic; Telecommunications
SC Engineering; Telecommunications
GA CI7OG
UT WOS:000354952800017
ER
PT J
AU Boling, MC
Nguyen, A
Yau, R
Cameron, KL
Beutler, A
Padua, DA
Marshall, S
AF Boling, M. C.
Nguyen, A.
Yau, R.
Cameron, K. L.
Beutler, A.
Padua, D. A.
Marshall, S.
TI MOVEMENT CHARACTERISTICS ASSOCIATED WITH THE DEVELOPMENT OF CHRONIC KNEE
PAIN
SO OSTEOARTHRITIS AND CARTILAGE
LA English
DT Meeting Abstract
CT World Congress of the Osteoarthritis-Research-Society-International
(OARSI) on Osteoarthritis
CY APR 30-MAY 03, 2015
CL Seattle, WA
SP Osteoarthritis Res Soc Int
C1 [Boling, M. C.] Univ N Florida, Jacksonville, FL USA.
[Nguyen, A.] High Point Univ, High Point, NC USA.
[Yau, R.; Padua, D. A.; Marshall, S.] Univ N Carolina, Chapel Hill, NC USA.
[Cameron, K. L.] Keller Army Hosp, West Point, NY USA.
[Beutler, A.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1063-4584
EI 1522-9653
J9 OSTEOARTHR CARTILAGE
JI Osteoarthritis Cartilage
PD APR
PY 2015
VL 23
SU 2
MA 62
BP A60
EP A61
PG 2
WC Orthopedics; Rheumatology
SC Orthopedics; Rheumatology
GA CI8VC
UT WOS:000355048800095
ER
PT J
AU Padua, DA
Cameron, KL
Beutler, AI
de la Motte, SJ
Kucera, KL
Golightly, YM
Marshall, SW
AF Padua, D. A.
Cameron, K. L.
Beutler, A. I.
de la Motte, S. J.
Kucera, K. L.
Golightly, Y. M.
Marshall, S. W.
TI PROSPECTIVE EVALUATION OF MUSCULOSKELETAL INJURY HISTORY AS PREDICTORS
FOR ANTERIOR CRUCIATE LIGAMENT INJURY RISK: THE JUMP-ACL STUDY
SO OSTEOARTHRITIS AND CARTILAGE
LA English
DT Meeting Abstract
CT World Congress of the Osteoarthritis-Research-Society-International
(OARSI) on Osteoarthritis
CY APR 30-MAY 03, 2015
CL Seattle, WA
SP Osteoarthritis Res Soc Int
C1 [Padua, D. A.; Kucera, K. L.; Golightly, Y. M.; Marshall, S. W.] Univ N Carolina, Chapel Hill, NC USA.
[Cameron, K. L.] Keller Army Hosp, West Point, NY USA.
[Beutler, A. I.; de la Motte, S. J.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA.
NR 0
TC 0
Z9 0
U1 0
U2 4
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1063-4584
EI 1522-9653
J9 OSTEOARTHR CARTILAGE
JI Osteoarthritis Cartilage
PD APR
PY 2015
VL 23
SU 2
MA 261
BP A171
EP A172
PG 2
WC Orthopedics; Rheumatology
SC Orthopedics; Rheumatology
GA CI8VC
UT WOS:000355048800291
ER
PT J
AU Rhee, SY
Blanco, JL
Jordan, MR
Taylor, J
Lemey, P
Varghese, V
Hamers, RL
Bertagnolio, S
de Wit, TR
Aghokeng, AF
Albert, J
Avi, R
Avila-Rios, S
Bessong, PO
Brooks, JI
Boucher, CAB
Brumme, ZL
Busch, MP
Bussmann, H
Chaix, ML
Chin, BS
D'Aquin, TT
De Gascun, CF
Derache, A
Descamps, D
Deshpande, AK
Djoko, CF
Eshleman, SH
Fleury, H
Frange, P
Fujisaki, S
Harrigan, PR
Hattori, J
Holguin, A
Hunt, GM
Ichimura, H
Kaleebu, P
Katzenstein, D
Kiertiburanakul, S
Kim, JH
Kim, SS
Li, YP
Lutsar, I
Morris, L
Ndembi, N
Peng, NGK
Paranjape, RS
Peeters, M
Poljak, M
Price, MA
Ragonnet-Cronin, ML
Reyes-Teran, G
Rolland, M
Sirivichayakul, S
Smith, DM
Soares, MA
Soriano, VV
Ssemwanga, D
Stanojevic, M
Stefani, MA
Sugiura, W
Sungkanuparph, S
Tanuri, A
Tee, KK
Truong, HHM
van de Vijver, DAMC
Vidal, N
Yang, CF
Yang, RG
Yebra, G
Ioannidis, JPA
Vandamme, AM
Shafer, RW
AF Rhee, Soo-Yon
Blanco, Jose Luis
Jordan, Michael R.
Taylor, Jonathan
Lemey, Philippe
Varghese, Vici
Hamers, Raph L.
Bertagnolio, Silvia
de Wit, TobiasF. Rinke
Aghokeng, Avelin F.
Albert, Jan
Avi, Radko
Avila-Rios, Santiago
Bessong, Pascal O.
Brooks, James I.
Boucher, Charles A. B.
Brumme, Zabrina L.
Busch, Michael P.
Bussmann, Hermann
Chaix, Marie-Laure
Chin, Bum Sik
D'Aquin, Toni T.
De Gascun, Cillian F.
Derache, Anne
Descamps, Diane
Deshpande, Alaka K.
Djoko, Cyrille F.
Eshleman, Susan H.
Fleury, Herve
Frange, Pierre
Fujisaki, Seiichiro
Harrigan, P. Richard
Hattori, Junko
Holguin, Africa
Hunt, Gillian M.
Ichimura, Hiroshi
Kaleebu, Pontiano
Katzenstein, David
Kiertiburanakul, Sasisopin
Kim, Jerome H.
Kim, Sung Soon
Li, Yanpeng
Lutsar, Irja
Morris, Lynn
Ndembi, Nicaise
Peng, Kee N. G.
Paranjape, Ramesh S.
Peeters, Martine
Poljak, Mario
Price, Matt A.
Ragonnet-Cronin, Manon L.
Reyes-Teran, Gustavo
Rolland, Morgane
Sirivichayakul, Sunee
Smith, Davey M.
Soares, Marcelo A.
Soriano, Vincent V.
Ssemwanga, Deogratius
Stanojevic, Maja
Stefani, Mariane A.
Sugiura, Wataru
Sungkanuparph, Somnuek
Tanuri, Amilcar
Tee, Kok Keng
Truong, Hong-Ha M.
van de Vijver, David A. M. C.
Vidal, Nicole
Yang, Chunfu
Yang, Rongge
Yebra, Gonzalo
Ioannidis, John P. A.
Vandamme, Anne-Mieke
Shafer, Robert W.
TI Geographic and Temporal Trends in the Molecular Epidemiology and Genetic
Mechanisms of Transmitted HIV-1 Drug Resistance: An Individual-Patient-
and Sequence-Level Meta-Analysis
SO PLOS MEDICINE
LA English
DT Article
ID RESOURCE-LIMITED SETTINGS; OLIGONUCLEOTIDE LIGATION ASSAY;
TREATMENT-NAIVE INDIVIDUALS; SUB-SAHARAN AFRICA; REVERSE-TRANSCRIPTASE;
VIROLOGICAL FAILURE; ANTIRETROVIRAL TREATMENT; TREATMENT PROGRAMS;
META-REGRESSION; SOUTH-AFRICA
AB Background
Regional and subtype-specific mutational patterns of HIV-1 transmitted drug resistance (TDR) are essential for informing first-line antiretroviral (ARV) therapy guidelines and designing diagnostic assays for use in regions where standard genotypic resistance testing is not affordable. We sought to understand the molecular epidemiology of TDR and to identify the HIV-1 drug-resistance mutations responsible for TDR in different regions and virus subtypes.
Methods and Findings
We reviewed all GenBank submissions of HIV-1 reverse transcriptase sequences with or without protease and identified 287 studies published between March 1, 2000, and December 31, 2013, with more than 25 recently or chronically infected ARV-naive individuals. These studies comprised 50,870 individuals from 111 countries. Each set of study sequences was analyzed for phylogenetic clustering and the presence of 93 surveillance drug-resistance mutations (SDRMs). The median overall TDR prevalence in sub-Saharan Africa (SSA), south/southeast Asia (SSEA), upper-income Asian countries, Latin America/Caribbean, Europe, and North America was 2.8%, 2.9%, 5.6%, 7.6%, 9.4%, and 11.5%, respectively. In SSA, there was a yearly 1.09-fold (95% CI: 1.05-1.14) increase in odds of TDR since national ARV scale-up attributable to an increase in non-nucleoside reverse transcriptase inhibitor (NNRTI) resistance. The odds of NNRTI-associated TDR also increased in Latin America/Caribbean (odds ratio [OR] = 1.16; 95% CI: 1.06-1.25), North America (OR = 1.19; 95% CI: 1.12-1.26), Europe (OR = 1.07; 95% CI: 1.01-1.13), and upper-income Asian countries (OR = 1.33; 95% CI: 1.12-1.55). In SSEA, there was no significant change in the odds of TDR since national ARV scale-up (OR = 0.97; 95% CI: 0.92-1.02). An analysis limited to sequences with mixtures at less than 0.5% of their nucleotide positions-a proxy for recent infection-yielded trends comparable to those obtained using the complete dataset. Four NNRTI SDRMs-K101E, K103N, Y181C, and G190A-accounted for > 80% of NNRTI-associated TDR in all regions and subtypes. Sixteen nucleoside reverse transcriptase inhibitor (NRTI) SDRMs accounted for > 69% of NRTI-associated TDR in all regions and subtypes. In SSA and SSEA, 89% of NNRTI SDRMs were associated with high-level resistance to nevirapine or efavirenz, whereas only 27% of NRTI SDRMs were associated with high-level resistance to zidovudine, lamivudine, tenofovir, or abacavir. Of 763 viruses with TDR in SSA and SSEA, 725 (95%) were genetically dissimilar; 38 (5%) formed 19 sequence pairs. Inherent limitations of this study are that some cohorts may not represent the broader regional population and that studies were heterogeneous with respect to duration of infection prior to sampling.
Conclusions
Most TDR strains in SSA and SSEA arose independently, suggesting that ARV regimens with a high genetic barrier to resistance combined with improved patient adherence may mitigate TDR increases by reducing the generation of new ARV-resistant strains. A small number of NNRTI-resistance mutations were responsible for most cases of high-level resistance, suggesting that inexpensive point-mutation assays to detect these mutations may be useful for pre-therapy screening in regions with high levels of TDR. In the context of a public health approach to ARV therapy, a reliable point-of-care genotypic resistance test could identify which patients should receive standard first-line therapy and which should receive a protease-inhibitor-containing regimen.
C1 [Rhee, Soo-Yon; Varghese, Vici; Katzenstein, David; Shafer, Robert W.] Stanford Univ, Dept Med, Stanford, CA 94305 USA.
[Blanco, Jose Luis] Univ Barcelona, Hosp Clin Univ, Inst Invest Biomed August Pi & Sunyer, Barcelona, Spain.
[Jordan, Michael R.] Tufts Univ, Sch Med, Boston, MA 02111 USA.
[Taylor, Jonathan] Stanford Univ, Dept Stat, Stanford, CA 94305 USA.
[Lemey, Philippe; Vandamme, Anne-Mieke] Univ Leuven, KU Leuven, Dept Microbiol & Immunol, Rega Inst Med Res Clin & Epidemiol Virol, Leuven, Belgium.
[Hamers, Raph L.; de Wit, TobiasF. Rinke] Univ Amsterdam, Acad Med Ctr, Dept Global Hlth & Internal Med, NL-1105 AZ Amsterdam, Netherlands.
[Hamers, Raph L.; de Wit, TobiasF. Rinke] Amsterdam Inst Global Hlth & Dev, Amsterdam, Netherlands.
[Bertagnolio, Silvia] WHO, CH-1211 Geneva, Switzerland.
[Aghokeng, Avelin F.] Virol Lab CREMER IMPM, Yaounde, Cameroon.
[Albert, Jan] Karolinska Inst, Dept Microbiol Tumor & Cell Biol, Stockholm, Sweden.
[Albert, Jan] Karolinska Univ Hosp, Dept Clin Microbiol, Stockholm, Sweden.
[Avi, Radko; Lutsar, Irja] Univ Tartu, Dept Microbiol, EE-50090 Tartu, Estonia.
[Avila-Rios, Santiago; Reyes-Teran, Gustavo] Ctr Res Infect Dis, Natl Inst Resp Dis, Mexico City, DF, Mexico.
[Bessong, Pascal O.] Univ Venda, Dept Microbiol, HIV AIDS & Global Hlth Res Programme, Thohoyandou, South Africa.
[Brooks, James I.] Publ Hlth Agcy Canada, Natl HIV & Retrovirol Labs, Ottawa, ON, Canada.
[Boucher, Charles A. B.; van de Vijver, David A. M. C.] Erasmus Univ, Erasmus Med Ctr, Dept Virosci, Rotterdam, Netherlands.
[Brumme, Zabrina L.; Harrigan, P. Richard] British Columbia Ctr Excellence HIV AIDS, Vancouver, BC, Canada.
[Brumme, Zabrina L.] Simon Fraser Univ, Fac Hlth Sci, Burnaby, BC V5A 1S6, Canada.
[Busch, Michael P.] Blood Syst Res Inst, San Francisco, CA USA.
[Bussmann, Hermann] Botswana Harvard AIDS Inst Partnership, Gaborone, Botswana.
[Chaix, Marie-Laure] Univ Paris Diderot, Hop St Louis, Lab Virol, INSERM,U941, Paris, France.
[Chin, Bum Sik] Natl Med Ctr, Ctr Infect Dis, Seoul, South Korea.
[D'Aquin, Toni T.] CIRBA Programme PACCI, Abidjan, Cote Ivoire.
[De Gascun, Cillian F.] Univ Coll Dublin, UCD Natl Virus Reference Lab, Dublin 2, Ireland.
[Derache, Anne] Hop La Pitie Salpetriere, Dept Virol, Paris, France.
[Descamps, Diane] Univ Paris Diderot, Hop Bichat Claude Bernard, AP HP, INSERM,UMR 1137,Lab Virol, Paris, France.
[Deshpande, Alaka K.] Grant Med Coll, Dept Med, Mumbai, Maharashtra, India.
[Deshpande, Alaka K.] Sir Jamshedjee Jeejeebhoy Grp Hosp, Mumbai, Maharashtra, India.
[Djoko, Cyrille F.] EMAT CRESAR, Intendance Round About, Global Viral Cameroon, Yaounde, Cameroon.
[Eshleman, Susan H.] Johns Hopkins Univ, Sch Med, Dept Pathol, Baltimore, MD 21205 USA.
[Fleury, Herve] Univ Bordeaux, Ctr Hosp Univ Bordeaux, CNRS, Lab Virol,UMR 5234, Bordeaux, France.
[Frange, Pierre] Hop Necker Enfants Malad, Dept Microbiol, Paris, France.
[Fujisaki, Seiichiro] Natl Inst Infect Dis, Influenza Virus Res Ctr, Tokyo, Japan.
[Hattori, Junko; Sugiura, Wataru] Nagoya Med Ctr, Natl Hosp Org, Nagoya, Aichi, Japan.
[Holguin, Africa; Yebra, Gonzalo] Hosp Univ Ramon y Cajal, Inst Ramon y Cajal Invest Sanitaria, Dept Microbiol, Madrid, Spain.
[Hunt, Gillian M.; Morris, Lynn] Natl Inst Communicable Dis, Ctr HIV & STIs, Johannesburg, South Africa.
[Ichimura, Hiroshi] Kanazawa Univ, Dept Viral Infect & Int Hlth, Grad Sch Med Sci, Kanazawa, Ishikawa, Japan.
[Kaleebu, Pontiano; Ssemwanga, Deogratius] MRC UVRI Uganda Res Unit AIDS, Entebbe, Uganda.
[Kiertiburanakul, Sasisopin; Sungkanuparph, Somnuek] Mahidol Univ, Ramathibodi Hosp, Fac Med, Bangkok 10400, Thailand.
[Kim, Jerome H.; Rolland, Morgane] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD USA.
[Kim, Sung Soon] Korea Natl Inst Hlth, Div Aids, Osong, Chungcheongbuk, South Korea.
[Li, Yanpeng; Yang, Rongge] Chinese Acad Sci, Wuhan Inst Virol, State Key Lab Virol, Wuhan, Peoples R China.
[Ndembi, Nicaise] Inst Human Virol, Abuja, Nigeria.
[Peng, Kee N. G.; Tee, Kok Keng] Univ Malaya, Fac Med, Dept Med, Kuala Lumpur, Malaysia.
[Paranjape, Ramesh S.] Indian Council Med Res, Natl AIDS Res Inst, Pune, Maharashtra, India.
[Peeters, Martine] INSERM, U1175, UMR 233, Inst Rech Dev, F-34394 Montpellier, France.
[Peeters, Martine] Univ Montpellier, F-34394 Montpellier, France.
[Peeters, Martine] Computat Biol Inst, Montpellier, France.
[Poljak, Mario] Univ Ljubljana, Fac Med, Inst Microbiol, Ljubljana, Slovenia.
[Price, Matt A.] Int AIDS Vaccine Initiat, Dept Med Affairs, New York, NY USA.
[Price, Matt A.] Univ Calif San Francisco, Sch Med, Dept Epidemiol & Biostat, San Francisco, CA USA.
[Ragonnet-Cronin, Manon L.] Univ Edinburgh, Edinburgh, Midlothian, Scotland.
[Sirivichayakul, Sunee] Chulalongkorn Univ, Fac Med, Bangkok 10330, Thailand.
[Smith, Davey M.] Univ Calif San Diego, La Jolla, CA 92093 USA.
[Soares, Marcelo A.; Tanuri, Amilcar] Univ Fed Rio de Janeiro, Rio De Janeiro, Brazil.
[Soriano, Vincent V.] Hosp Carlos III, Dept Infect Dis, Madrid, Spain.
[Stanojevic, Maja] Univ Belgrade, Inst Microbiol & Immunol, Fac Med, Belgrade, Serbia.
[Stefani, Mariane A.] Univ Fed Goias, Goiania, Go, Brazil.
[Truong, Hong-Ha M.] Univ Calif San Francisco, Dept Med, San Francisco, CA USA.
[Vidal, Nicole] Univ Montpellier I, Inst Rech Dev, Montpellier, France.
[Yang, Chunfu] Ctr Dis Control & Prevent, Int Lab Branch, Div Global HIV AIDS, Ctr Global Hlth, Atlanta, GA USA.
[Ioannidis, John P. A.] Stanford Univ, Dept Med, Stanford Prevent Res Ctr, Stanford, CA 94305 USA.
[Ioannidis, John P. A.] Stanford Univ, Meta Res Innovat Ctr Stanford, Stanford, CA 94305 USA.
[Vandamme, Anne-Mieke] Univ Nova Lisboa, Global Hlth & Trop Med, Unidade Microbiol, Inst Higiene Med & Trop, P-1200 Lisbon, Portugal.
RP Rhee, SY (reprint author), Stanford Univ, Dept Med, Stanford, CA 94305 USA.
EM syrhee@stanford.edu
RI lutsar, irja/H-3177-2015; Tee, Kok Keng/A-8148-2008; Vandamme, Anne
Mieke/I-4127-2012;
OI Tee, Kok Keng/0000-0002-7923-5448; Vandamme, Anne
Mieke/0000-0002-6594-2766; , Lynn/0000-0003-3961-7828; Yebra,
Gonzalo/0000-0002-3472-3667
FU NIH [R01 AI068581]; Bill & Melinda Gates Foundation grant; CFAR
[1P30A142853]
FX SYR, VV, and RWS were supported in part from NIH grant R01 AI068581. SYR
and RWS were supported in part from an Bill & Melinda Gates Foundation
grant. MRJ is supported by CFAR grant 1P30A142853. No funding bodies had
any role in study design, data collection and analysis, decision to
publish, or preparation of the manuscript.
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PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1549-1676
J9 PLOS MED
JI PLos Med.
PD APR
PY 2015
VL 12
IS 4
AR e1001810
DI 10.1371/journal.pmed.1001810
PG 29
WC Medicine, General & Internal
SC General & Internal Medicine
GA CI5UQ
UT WOS:000354825700001
PM 25849352
ER
PT J
AU Rigler, M
Buh, J
Hoffmann, MP
Kirste, R
Bobea, M
Mita, S
Gerhold, MD
Collazo, R
Sitar, Z
Zgonik, M
AF Rigler, Martin
Buh, Joze
Hoffmann, Marc P.
Kirste, Ronny
Bobea, Milena
Mita, Seiji
Gerhold, Michael D.
Collazo, Ramon
Sitar, Zlatko
Zgonik, Marko
TI Optical characterization of Al- and N-polar AlN waveguides for
integrated optics
SO APPLIED PHYSICS EXPRESS
LA English
DT Article
ID EFFECTIVE-MEDIUM MODELS; SPECTROSCOPIC ELLIPSOMETRY; REFRACTIVE-INDEXES;
SURFACE-ROUGHNESS; THIN-FILMS; GAN; GENERATION; GROWTH
AB Dispersion of the extraordinary and ordinary refractive indices of Al- and N-polar AlN waveguides is measured by multiple angle-of-incidence and spectroscopic ellipsometry techniques. The polarity-controlled AlN layers are grown by metal-organic chemical vapor deposition on (0001)sapphire substrates. Taking into consideration the different surface morphologies of the Al-and N-polar AlN waveguides, we propose two optical models to describe the measured ellipsometry data. The results indicate that there is no difference between the refractive indices of the AlN grown in opposite directions, which confirms the potential of the AlN lateral polar structures for use in nonlinear optical applications based on quasi phase matching. (C) 2015 The Japan Society of Applied Physics
C1 [Rigler, Martin; Zgonik, Marko] Univ Ljubljana, Fac Math & Phys, Ljubljana 1000, Slovenia.
[Buh, Joze; Zgonik, Marko] Jozef Stefan Inst, Ljubljana 1000, Slovenia.
[Hoffmann, Marc P.; Kirste, Ronny; Bobea, Milena; Collazo, Ramon; Sitar, Zlatko] N Carolina State Univ, Dept Mat Sci & Engn, Raleigh, NC 27606 USA.
[Mita, Seiji] HexaTech Inc, Morrisville, NC 27606 USA.
[Gerhold, Michael D.] Army Res Off, Engn Sci Directorate, Res Triangle Pk, NC 27703 USA.
RP Rigler, M (reprint author), Univ Ljubljana, Fac Math & Phys, Jadranska 19, Ljubljana 1000, Slovenia.
EM martin.rigler@fmf.uni-lj.si
RI Zgonik, Marko/K-9092-2015
OI Zgonik, Marko/0000-0002-2307-8797
FU National Science Foundation [DMR-1108071, DMR-1312582]; Army Research
Laboratory [W911NF-04- D-0003-0014]
FX We acknowledge the CENN Nanocenter for allowing the use of the Accurion
spectroscopic ellipsometer and the FEI focused ion beam. The North
Carolina State University (NCSU) group acknowledges financial support
from the National Science Foundation under contracts DMR-1108071 and
DMR-1312582, and from the Army Research Laboratory (Contract No.
W911NF-04- D-0003-0014, William Clark program monitor).
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PU IOP PUBLISHING LTD
PI BRISTOL
PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND
SN 1882-0778
EI 1882-0786
J9 APPL PHYS EXPRESS
JI Appl. Phys. Express
PD APR
PY 2015
VL 8
IS 4
AR 042603
DI 10.7567/APEX.8.042603
PG 4
WC Physics, Applied
SC Physics
GA CI4DK
UT WOS:000354696900016
ER
PT J
AU Choi, I
Chung, AW
Suscovich, TJ
Rerks-Ngarm, S
Pitisuttithum, P
Nitayaphan, S
Kaewkungwal, J
O'Connell, RJ
Francis, D
Robb, ML
Michael, NL
Kim, JH
Alter, G
Ackerman, ME
Bailey-Kellogg, C
AF Choi, Ickwon
Chung, Amy W.
Suscovich, Todd J.
Rerks-Ngarm, Supachai
Pitisuttithum, Punnee
Nitayaphan, Sorachai
Kaewkungwal, Jaranit
O'Connell, Robert J.
Francis, Donald
Robb, Merlin L.
Michael, Nelson L.
Kim, Jerome H.
Alter, Galit
Ackerman, Margaret E.
Bailey-Kellogg, Chris
TI Machine Learning Methods Enable Predictive Modeling of Antibody Feature:
Function Relationships in RV144 Vaccinees
SO PLOS COMPUTATIONAL BIOLOGY
LA English
DT Article
ID CELL-MEDIATED CYTOTOXICITY; HIV-1/SIV CHIMERIC VIRUS; NEUTRALIZING
ANTIBODIES; DISEASE PROGRESSION; HIGH-THROUGHPUT; EFFICACY TRIAL;
REGRESSION; INFECTION; VACCINATION; PROTECTION
AB The adaptive immune response to vaccination or infection can lead to the production of specific antibodies to neutralize the pathogen or recruit innate immune effector cells for help. The non-neutralizing role of antibodies in stimulating effector cell responses may have been a key mechanism of the protection observed in the RV144 HIV vaccine trial. In an extensive investigation of a rich set of data collected from RV144 vaccine recipients, we here employ machine learning methods to identify and model associations between antibody features (IgG subclass and antigen specificity) and effector function activities (antibody dependent cellular phagocytosis, cellular cytotoxicity, and cytokine release). We demonstrate via cross-validation that classification and regression approaches can effectively use the antibody features to robustly predict qualitative and quantitative functional outcomes. This integration of antibody feature and function data within a machine learning framework provides a new, objective approach to discovering and assessing multivariate immune correlates.
C1 [Choi, Ickwon; Bailey-Kellogg, Chris] Dartmouth Coll, Dept Comp Sci, Hanover, NH 03755 USA.
[Chung, Amy W.; Suscovich, Todd J.; Alter, Galit] Massachusetts Gen Hosp, Ragon Inst, MIT, Boston, MA 02114 USA.
[Chung, Amy W.; Suscovich, Todd J.; Alter, Galit] Harvard, Boston, MA USA.
[Rerks-Ngarm, Supachai] Minist Publ Hlth, Dept Dis Control, Nonthaburi, Thailand.
[Pitisuttithum, Punnee; Kaewkungwal, Jaranit] Mahidol Univ, Fac Trop Med, Bangkok, Thailand.
[Nitayaphan, Sorachai] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand.
[O'Connell, Robert J.] AFRIMS, US Army Med Component, Dept Retrovirol, Bangkok, Thailand.
[Francis, Donald] Global Solut Infect Dis GSID, San Francisco, CA USA.
[Robb, Merlin L.; Michael, Nelson L.; Kim, Jerome H.] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD USA.
[Robb, Merlin L.] US Mil HIV Res Program, Henry Jackson Fdn HIV Program, Bethesda, MD USA.
[Ackerman, Margaret E.] Dartmouth Coll, Thayer Sch Engn, Hanover, NH 03755 USA.
RP Choi, I (reprint author), Dartmouth Coll, Dept Comp Sci, Hanover, NH 03755 USA.
EM cbk@cs.dartmouth.edu
OI Chung, Amy/0000-0003-0020-9704
FU US Military HIV Research Program (MHRP); Collaboration for AIDS Vaccine
Discovery [OPP1032817]; NSF [IIS-0905206]; American Australian
Association; National Health & Medical Research Center [NHMRC
APP1036470]; U.S. Army Medical Research and Material Command (USAMRMC)
[Y1-AI-2642-12]; National Institutes of Allergy and Infectious Diseases
[Y1-AI-2642-12]; Henry M. Jackson Foundation for the Advancement of
Military Medicine, Inc. [W81XWH-07-2-0067]; U.S. Department of Defense
[W81XWH-07-2-0067]; [NIH3R01Al080289-02S1]; [5R01Al080289-03]
FX These studies were supported by the US Military HIV Research Program
(MHRP), the Collaboration for AIDS Vaccine Discovery (OPP1032817:
Leveraging Antibody Effector Function) to MEA, GA, and CBK, and
NIH3R01Al080289-02S1 and 5R01Al080289-03 to GA. IC was supported by NSF
grant IIS-0905206. AWC was supported by the American Australian
Association (Amgen Fellowship) and National Health & Medical Research
Center (NHMRC APP1036470). The work was also supported in part by an
Interagency Agreement Y1-AI-2642-12 between the U.S. Army Medical
Research and Material Command (USAMRMC) and the National Institutes of
Allergy and Infectious Diseases and by a cooperative agreement
(W81XWH-07-2-0067) between the Henry M. Jackson Foundation for the
Advancement of Military Medicine, Inc., and the U.S. Department of
Defense. The funders had no role in study design, data collection and
analysis, decision to publish, or preparation of the manuscript.
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PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1553-734X
EI 1553-7358
J9 PLOS COMPUT BIOL
JI PLoS Comput. Biol.
PD APR
PY 2015
VL 11
IS 4
AR UNSP e1004185
DI 10.1371/journal.pcbi.1004185
PG 20
WC Biochemical Research Methods; Mathematical & Computational Biology
SC Biochemistry & Molecular Biology; Mathematical & Computational Biology
GA CI1PX
UT WOS:000354517600034
PM 25874406
ER
PT J
AU Clark, MP
Nijssen, B
Lundquist, JD
Kavetski, D
Rupp, DE
Woods, RA
Freer, JE
Gutmann, ED
Wood, AW
Brekke, LD
Arnold, JR
Gochis, DJ
Rasmussen, RM
AF Clark, Martyn P.
Nijssen, Bart
Lundquist, Jessica D.
Kavetski, Dmitri
Rupp, David E.
Woods, Ross A.
Freer, Jim E.
Gutmann, Ethan D.
Wood, Andrew W.
Brekke, Levi D.
Arnold, Jeffrey R.
Gochis, David J.
Rasmussen, Roy M.
TI A unified approach for process-based hydrologic modeling: 1. Modeling
concept
SO WATER RESOURCES RESEARCH
LA English
DT Article
DE unified model; scaling behavior; hydrometeorology
ID GENERAL-CIRCULATION MODELS; STORAGE BOUSSINESQ MODEL; PHYSICALLY BASED
MODEL; VARIABLE SOURCE AREAS; TORNE-KALIX BASIN; LAND-SURFACE;
INTERCOMPARISON PROJECT; SUBSURFACE FLOW; HETEROGENEOUS HILLSLOPES;
WATERSHED THERMODYNAMICS
AB This work advances a unified approach to process-based hydrologic modeling to enable controlled and systematic evaluation of multiple model representations (hypotheses) of hydrologic processes and scaling behavior. Our approach, which we term the Structure for Unifying Multiple Modeling Alternatives (SUMMA), formulates a general set of conservation equations, providing the flexibility to experiment with different spatial representations, different flux parameterizations, different model parameter values, and different time stepping schemes. In this paper, we introduce the general approach used in SUMMA, detailing the spatial organization and model simplifications, and how different representations of multiple physical processes can be combined within a single modeling framework. We discuss how SUMMA can be used to systematically pursue the method of multiple working hypotheses in hydrology. In particular, we discuss how SUMMA can help tackle major hydrologic modeling challenges, including defining the appropriate complexity of a model, selecting among competing flux parameterizations, representing spatial variability across a hierarchy of scales, identifying potential improvements in computational efficiency and numerical accuracy as part of the numerical solver, and improving understanding of the various sources of model uncertainty.
C1 [Clark, Martyn P.; Gutmann, Ethan D.; Wood, Andrew W.; Gochis, David J.; Rasmussen, Roy M.] Natl Ctr Atmospher Res, Hydrometeorol Applicat Program, Res Applicat Lab, Boulder, CO 80307 USA.
[Nijssen, Bart; Lundquist, Jessica D.] Univ Washington, Dept Civil & Environm Engn, Seattle, WA 98195 USA.
[Kavetski, Dmitri] Univ Adelaide, Sch Civil Environm & Min Engn, Adelaide, SA, Australia.
[Rupp, David E.] Oregon State Univ, Oregon Climate Change Res Inst, Coll Earth Ocean & Atmospher Sci, Corvallis, OR 97331 USA.
[Woods, Ross A.] Univ Bristol, Fac Engn, Bristol, Avon, England.
[Freer, Jim E.] Univ Bristol, Sch Geog Sci, Bristol, Avon, England.
[Brekke, Levi D.] US Bur Reclamat, Denver, CO 80225 USA.
[Arnold, Jeffrey R.] US Army Corps Engineers, Seattle, WA USA.
RP Clark, MP (reprint author), Natl Ctr Atmospher Res, Hydrometeorol Applicat Program, Res Applicat Lab, POB 3000, Boulder, CO 80307 USA.
EM mclark@ucar.edu
RI Woods, Ross/C-6696-2013; Freer, Jim/C-7335-2009; Clark,
Martyn/A-5560-2015; Rupp, David/G-8171-2014; Nijssen, Bart/B-1013-2012;
Gutmann, Ethan/I-5728-2012
OI Woods, Ross/0000-0002-5732-5979; Clark, Martyn/0000-0002-2186-2625;
Nijssen, Bart/0000-0002-4062-0322; Gutmann, Ethan/0000-0003-4077-3430
FU U.S. Army Corps of Engineers; Bureau of Reclamation through National
Oceanic and Atmospheric Administration (NOAA) Modeling Analysis
Predictions and Projections (MAPP) program [R4310142]; National Science
Foundation [EAR-1215809]
FX We thank David Tarboton, Mary Hill, Michael Barlage, Fei Chen, and David
Lawrence for comments on an earlier draft of this manuscript, and Cindy
Halley-Gotway and Kevin Sampson for their help in producing the figures
for the paper. We thank the three anonymous reviewers and Keith Beven
for their detailed and constructive comments that substantially improved
the manuscript. This work was supported through a contract with the U.S.
Army Corps of Engineers, through a Cooperative Agreement with the Bureau
of Reclamation, through a grant from the National Oceanic and
Atmospheric Administration (NOAA) Modeling Analysis Predictions and
Projections (MAPP) program (R4310142), and through a grant from the
National Science Foundation (EAR-1215809). All of the spatial data used
to create the figures in this paper are available from the lead author
upon request.
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U2 64
PU AMER GEOPHYSICAL UNION
PI WASHINGTON
PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA
SN 0043-1397
EI 1944-7973
J9 WATER RESOUR RES
JI Water Resour. Res.
PD APR
PY 2015
VL 51
IS 4
BP 2498
EP 2514
DI 10.1002/2015WR017198
PG 17
WC Environmental Sciences; Limnology; Water Resources
SC Environmental Sciences & Ecology; Marine & Freshwater Biology; Water
Resources
GA CI4PH
UT WOS:000354733500036
ER
PT J
AU Homeyer, DC
Sanchez, CJ
Mende, K
Beckius, ML
Murray, CK
Wenke, JC
Akers, KS
AF Homeyer, Diane C.
Sanchez, Carlos J.
Mende, Katrin
Beckius, Miriam L.
Murray, Clinton K.
Wenke, Joseph C.
Akers, Kevin S.
TI In Vitro activity of Melaleuca alternifolia (tea tree) oil on
filamentous fungi and toxicity to human cells
SO MEDICAL MYCOLOGY
LA English
DT Article
DE cell viability; cytotoxicity; invasive fungal infection; Melaleuca
alternifolia; tea tree oil
ID RESISTANT STAPHYLOCOCCUS-AUREUS; DONOR SKIN VIABILITY; CUTANEOUS
ASPERGILLOSIS; TOPICAL PREPARATIONS; MAJOR COMPONENTS; FIBROBLAST CELLS;
CONTROLLED-TRIAL; AMPHOTERICIN-B; VORICONAZOLE; TERPINEN-4-OL
AB Invasive fungal wound infections (IFIs) are increasingly reported in trauma patients and cause considerable morbidity and mortality despite standard of care treatment in trauma centers by experienced medical personnel. Topical agents such as oil of melaleuca, also known as tea tree oil (TTO), have been proposed for adjunctive treatment of IFIs. We evaluated the activity of TTO against filamentous fungi associated with IFIs by testing 13 clinical isolates representing nine species via time-kill assay with seven concentrations of TTO (100%, 75%, 50%, 25%, 10%, 5%, and 1%). To ascertain the safety of topical application to wounds, cell viability assays were performed in vitro using human fibroblasts, keratinocytes, osteoblasts, and umbilical vein endothelial cells with 10 concentrations of TTO (75%, 50%, 25%, 10%, 5%, and 10-fold serial dilutions from 1 to 0.0001%) at five time points (5, 15, 30, 60, and 180 min). Compatibility of TTO with explanted porcine tissues was also assessed with eight concentrations of TTO (100%, 75%, 50%, 25%, 10%, 5%, 1%, and 0.1%) at the time points used for cellular assays and at 24 h. The time-kill studies showed that fungicidal activity was variable between isolates. The effect of TTO on cell viability was primarily concentration dependent with significant cytotoxicity at concentrations of >= 10% and >= 50% for cells lines and whole tissue, respectively. Our findings demonstrate that TTO possesses antifungal activity against filamentous fungi associated with IFIs; furthermore that negligible effects on whole tissues, in contrast to individual cells, were observed following exposure to TTO. Collectively, these findings indicate a potential use of TTO as topical treatment of IFIs.
C1 [Homeyer, Diane C.; Mende, Katrin; Murray, Clinton K.; Akers, Kevin S.] San Antonio Mil Med Ctr, Dept Med, Infect Dis Serv, Ft Sam Houston, TX 78234 USA.
[Sanchez, Carlos J.; Wenke, Joseph C.; Akers, Kevin S.] US Army Inst Surg Res, Extrem Trauma & Regenerat Med Task Area, Ft Sam Houston, TX USA.
[Mende, Katrin] Uniformed Serv Univ Hlth Sci, Infect Dis Clin Res Program, Bethesda, MD 20814 USA.
[Beckius, Miriam L.] Brooke Army Med Ctr, Dept Clin Invest, Ft Sam Houston, TX 78234 USA.
RP Homeyer, DC (reprint author), San Antonio Mil Med Ctr, Dept Med, Infect Dis Serv, Ft Sam Houston, TX 78234 USA.
EM dchomeyer@gmail.com
FU Armed Forces Health Surveillance Center; Global Emerging Infections
Surveillance and Response System; Combat Casualty Research Program,
Medical Research and Material Command
FX The views expressed herein are those of the authors and do not reflect
the official policy or position of the Department of the Army,
Department of the Air Force, Department of Defense, or the US
Government. The authors are employees of the US government. This work
was prepared as part of their official duties, and as such, there is no
copyright to be transferred. This work was supported by the Armed Forces
Health Surveillance Center including the Global Emerging Infections
Surveillance and Response System and by intramural funding from the
Combat Casualty Research Program, Medical Research and Material Command
to JCW.
NR 45
TC 1
Z9 1
U1 0
U2 13
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1369-3786
EI 1460-2709
J9 MED MYCOL
JI Med. Mycol.
PD APR
PY 2015
VL 53
IS 3
BP 285
EP 294
DI 10.1093/mmy/myu072
PG 10
WC Infectious Diseases; Mycology; Veterinary Sciences
SC Infectious Diseases; Mycology; Veterinary Sciences
GA CI1VK
UT WOS:000354532800010
PM 25631479
ER
PT J
AU Choi, JH
Greene, WA
Johnson, AJ
Chavko, M
Cleland, JM
McCarron, RM
Wang, HC
AF Choi, Jae Hyek
Greene, Whitney A.
Johnson, Anthony J.
Chavko, Mikulas
Cleland, Jeffery M.
McCarron, Richard M.
Wang, Heuy-Ching
TI Pathophysiology of blast-induced ocular trauma in rats after repeated
exposure to low-level blast overpressure
SO CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
LA English
DT Article
DE apoptosis; blast-induced ocular trauma; blast overpressure; gliosis;
optic neuropathy
ID FIBRILLARY ACIDIC PROTEIN; EXPERIMENTAL RODENT MODEL; GANGLION-CELL
DAMAGE; BRAIN-INJURY; RETINAL DEGENERATION; MOUSE MODEL; EYE;
EXPRESSION; PATTERN; COMBAT
AB BackgroundThe incidence of blast-induced ocular injury has dramatically increased due to advances in weaponry and military tactics. A single exposure to blast overpressure (BOP) has been shown to cause damage to the eye in animal models; however, on the battlefield, military personnel are exposed to BOP multiple times. The effects of repeated exposures to BOP on ocular tissues have not been investigated. The purpose of this study is to characterize the effects of single or repeated exposure on ocular tissues.
MethodsA compressed air shock tube was used to deliver 707KPa BOP to rats, once (single blast overpressure [SBOP]) or once daily for 5 days (repeated blast overpressure [RBOP]). Immunohistochemistry was performed to characterize the pathophysiology of ocular injuries induced by SBOP and RBOP. Apoptosis was determined by quantification activated caspase 3. Gliosis was examined by detection of glial fibrillary acidic protein (GFAP). Inflammation was examined by detection of CD68.
ResultsActivated caspase 3 was detected in ocular tissues from all animals subjected to BOP, while those exposed to RBOP had more activated caspase 3 in the optic nerve than those exposed to SBOP. GFAP was detected in the retinas from all animals subjected to BOP. CD68 was detected in optic nerves from all animals exposed to BOP.
ConclusionSBOP and RBOP induced retinal damage. RBOP caused more apoptosis in the optic nerve than SBOP, suggesting that RBOP causes more severe optic neuropathy than SBOP. SBOP and RBOP caused gliosis in the retina and increased inflammation in the optic nerve.
C1 [Choi, Jae Hyek; Greene, Whitney A.; Johnson, Anthony J.; Cleland, Jeffery M.; Wang, Heuy-Ching] US Army Inst Surg Res, Ocular Trauma Task Area, Jbsa Ft Sam Houston, TX USA.
[Chavko, Mikulas; McCarron, Richard M.] Naval Med Res Ctr, NeuroTrauma Dept, Silver Spring, MD USA.
RP Wang, HC (reprint author), US Army Inst Surg Res, 3698 Chambers Pass Ave,Bldg 3611, San Antonio, TX 78234 USA.
EM heuy-ching.h.wang.civ@mail.mil
FU U.S. Army Military Operational Medicine Research Program (MOMRP);
Clinical Rehabilitative Medicine Research Program (CRMRP)
FX U.S. Army Military Operational Medicine Research Program (MOMRP) and
Clinical Rehabilitative Medicine Research Program (CRMRP).
NR 30
TC 3
Z9 3
U1 3
U2 6
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1442-6404
EI 1442-9071
J9 CLIN EXP OPHTHALMOL
JI Clin. Exp. Ophthalmol.
PD APR
PY 2015
VL 43
IS 3
BP 239
EP 246
DI 10.1111/ceo.12407
PG 8
WC Ophthalmology
SC Ophthalmology
GA CH4RK
UT WOS:000354020400008
PM 25112787
ER
PT J
AU Pasiakos, SM
Margolis, LM
Orr, JS
AF Pasiakos, Stefan M.
Margolis, Lee M.
Orr, Jeb S.
TI Optimized dietary strategies to protect skeletal muscle mass during
periods of unavoidable energy deficit
SO FASEB JOURNAL
LA English
DT Review
DE leucine; military; mTORC1; lean body mass
ID ESSENTIAL AMINO-ACID; RANDOMIZED CONTROLLED-TRIAL; HEALTHY-YOUNG MEN;
GROWTH-FACTOR-I; FAT-FREE MASS; WEIGHT-LOSS; BODY-COMPOSITION;
RESISTANCE EXERCISE; PHYSICAL PERFORMANCE; ENDURANCE EXERCISE
AB Interactions between dietary protein and energy balance on the regulation of human skeletal muscle protein turnover are not well described. A dietary protein intake above the recommended dietary allowance during energy balance typically enhances nitrogen retention and up-regulates muscle protein synthesis, which in turn may promote positive protein balance and skeletal muscle accretion. Recent studies show that during energy deficit, muscle protein synthesis is down-regulated with concomitant increases in ubiquitin proteasome-mediated muscle proteolysis and nitrogen excretion, reflecting the loss of skeletal muscle mass. However, consuming high-protein diets (1.6-2.4 g/kg per day), or high-quality, protein-based meals (15-30 g whey) during energy deficit attenuates intracellular proteolysis, restores muscle protein synthesis, and mitigates skeletal muscle loss. These findings are particularly important for physically active, normal-weight individuals because attenuating the extent to which skeletal muscle mass is lost during energy deficit could prevent decrements in performance, reduce injury risk, and facilitate recovery. This article reviews the relationship between energy status, protein intake, and muscle protein turnover, and explores future research directives designed to protect skeletal muscle mass in physically active, normal-weight adults.
C1 [Pasiakos, Stefan M.; Margolis, Lee M.; Orr, Jeb S.] US Army, Environm Med Res Inst, Mil Nutr Div, Natick, MA 01760 USA.
RP Pasiakos, SM (reprint author), US Army, Environm Med Res Inst, 15 Kansas St,Bldg 42, Natick, MA 01760 USA.
EM stefan.pasiakos@usarmy.mil
RI Pasiakos, Stefan/E-6295-2014;
OI Pasiakos, Stefan/0000-0002-5378-5820; , Lee/0000-0002-0652-1304
FU U.S. Army Medical Research and Material Command
FX The authors thank Dr. Scott J. Montain for his support in the
development of this article. This work was supported by the U.S. Army
Medical Research and Material Command. The opinions or assertions
contained herein are the private views of the authors and are not to be
construed as official or as reflecting the views of the U.S. Army or the
U.S. Department of Defense. Any citations of commercial organizations
and trade names in this report do not constitute an official U.S.
Department of the Army endorsement of approval of the products or
services of these organizations.
NR 119
TC 8
Z9 8
U1 1
U2 15
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
EI 1530-6860
J9 FASEB J
JI Faseb J.
PD APR
PY 2015
VL 29
IS 4
BP 1136
EP 1142
DI 10.1096/fj.14-266890
PG 7
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA CH5ZN
UT WOS:000354115000003
PM 25550460
ER
PT J
AU Lee, JC
Nakama, H
Goebert, D
Alicata, D
AF Lee, June C.
Nakama, Helenna
Goebert, Deborah
Alicata, Daniel
TI Gender differences in reasons for methamphetamine use in an ethnically
diverse population in Hawaii
SO JOURNAL OF SUBSTANCE USE
LA English
DT Article
DE Amphetamine; mental health; sexual behaviours; substance use; women
ID MEN
AB Objectives: This preliminary study examined methamphetamine (MA) use behaviors and motivators for MA use among 46 ethnically diverse participants from an university-affiliated community hospital and narcotics anonymous groups in Hawaii.
Method: Data were collected among 46 participants using an anonymous survey.
Results: Results showed that both women and men use MA primarily to get high and to get more energy. Women were more likely than men to use MA to cope with negative feelings and for increased energy. Men were more likely than women to use MA for sexual reasons and due to peer pressure.
Conclusion: These results suggest that some women may be self-medicating with MA. Studying these behaviors may guide in developing future prevention and treatment strategies.
C1 [Lee, June C.; Goebert, Deborah; Alicata, Daniel] Univ Hawaii, Dept Psychiat, Honolulu, HI 96822 USA.
[Nakama, Helenna] Tripler Army Med Ctr, Dept Behav Hlth, Honolulu, HI USA.
RP Lee, JC (reprint author), 1356 Lusitana St,4th Floor Honolulu, Honolulu, HI 96813 USA.
EM jlee@dop.hawaii.edu
NR 10
TC 0
Z9 0
U1 5
U2 8
PU INFORMA HEALTHCARE
PI NEW YORK
PA 52 VANDERBILT AVE, NEW YORK, NY 10017 USA
SN 1465-9891
EI 1475-9942
J9 J SUBST USE
JI J. Subst. Use
PD APR
PY 2015
VL 20
IS 2
BP 93
EP 96
DI 10.3109/14659891.2013.859753
PG 4
WC Substance Abuse
SC Substance Abuse
GA CH3LN
UT WOS:000353932300003
ER
PT J
AU Pollard, KA
Tran, PK
Letowski, T
AF Pollard, Kimberly A.
Tran, Phuong K.
Letowski, Tomasz
TI The effect of vocal and demographic traits on speech intelligibility
over bone conduction
SO JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA
LA English
DT Article
ID FUNDAMENTAL-FREQUENCY CHARACTERISTICS; ACQUISITION TEST CAT;
INDIVIDUAL-DIFFERENCES; BACKGROUND-NOISE; AGE; SPEAKING; HEARING;
ADULTS; SEX; MICROPHONES
AB Bone conduction (BC) communication systems provide benefits over air conduction systems but are not in widespread use, partly due to problems with speech intelligibility. Contributing factors like device location and background noise have been explored, but little attention has been paid to the role of individual user differences. Because BC signals travel through an individual's skull and facial tissues, demographic factors such as user age, sex, race, or regional origin may influence sound transmission. Vocal traits such as pitch, spectral tilt, jitter, and shimmer may also play a role. Along with microphone placement and background noise, these factors can affect BC speech intelligibility. Eight diverse talkers were recorded with bone microphones on two different skull locations and in different background noise conditions. Twenty-four diverse listeners listened to these samples over BC and completed Modified Rhyme Tests for speech intelligibility. Forehead bone recordings were more intelligible than condyle recordings. In condyle recordings, female talkers, talkers with high fundamental frequency, and talkers in background noise were understood better, as were communications between talkers and listeners of the same regional origin. Listeners' individual traits had no significant effects. Thoughtful application of this knowledge can help improve BC communication for diverse users.
C1 [Pollard, Kimberly A.; Tran, Phuong K.; Letowski, Tomasz] US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA.
RP Pollard, KA (reprint author), US Army Res Lab, 520 Mulberry Point Rd, Aberdeen Proving Ground, MD 21005 USA.
EM kpollard@ucla.edu
FU Oak Ridge Associated Universities postdoctoral fellowship
FX The authors thank Tim Mermagen for developing the MRT software, Paula
Henry and Ashley Foots for hearing screenings and training, and Rachel
Weatherless, Debra Patton, Jeremy Gaston, and Bruce Amrein for helpful
comments. This research was conducted under an Oak Ridge Associated
Universities postdoctoral fellowship to K.A.P.
NR 67
TC 1
Z9 1
U1 0
U2 2
PU ACOUSTICAL SOC AMER AMER INST PHYSICS
PI MELVILLE
PA STE 1 NO 1, 2 HUNTINGTON QUADRANGLE, MELVILLE, NY 11747-4502 USA
SN 0001-4966
EI 1520-8524
J9 J ACOUST SOC AM
JI J. Acoust. Soc. Am.
PD APR
PY 2015
VL 137
IS 4
BP 2060
EP 2069
DI 10.1121/1.4916689
PG 10
WC Acoustics; Audiology & Speech-Language Pathology
SC Acoustics; Audiology & Speech-Language Pathology
GA CG9QV
UT WOS:000353653500060
PM 25920856
ER
PT J
AU Florio, LA
AF Florio, L. A.
TI Dynamic coupling of fluid and structural mechanics for simulating
particle motion and interaction in high speed compressible gas particle
laden flow
SO JOURNAL OF FLUIDS AND STRUCTURES
LA English
DT Article
DE Fluid-structure interaction; Computational fluid dynamics; Finite
element analysis; Particle flow; Two-phase; Plasticity
ID MOVING PARTICLES; HEAT-CONDUCTION; MODEL; COLLISIONS; DEFORMATION;
BEHAVIOR; COMPUTATION; NUMBER
AB In this work, structural finite element analyses of particles moving and interacting within high speed compressible flow are directly coupled to computational fluid dynamics and heat transfer analyses to provide more detailed and improved simulations of particle laden flow under these operating conditions. For a given solid material model, stresses and displacements throughout the solid body are determined with the particle-particle contact following an element to element local spring force model and local fluid induced forces directly calculated from the finite volume flow solution. Plasticity and particle deformation common in such a flow regime can be incorporated in a more rigorous manner than typical discrete element models where structural conditions are not directly modeled. Using the developed techniques, simulations of normal collisions between two I mm radius particles with initial particle velocities of 50-150 m/s are conducted with different levels of pressure driven gas flow moving normal to the initial particle motion for elastic and elastic-plastic with strain hardening based solid material models. In this manner, the relationships between the collision velocity, the material behavior models, and the fluid flow and the particle motion and deformation can be investigated. The elastic-plastic material behavior results in post collision velocities 16-50% of their precollision values while the elastic-based particle collisions nearly regained their initial velocity upon rebound. The elastic-plastic material models produce contact forces less than half of those for elastic collisions, longer contact times, and greater particle deformation. Fluid flow forces affect the particle motion even at high collision speeds regardless of the solid material behavior model. With the elastic models, the collision force varied little with the strength of the gas flow driver. For the elastic-plastic models, the larger particle deformation and the resulting increasingly asymmetric loading lead to growing differences in the collision force magnitudes and directions as the gas flow strength increased. The coupled finite volume flow and finite element structural analyses provide a capability to capture the interdependencies between the interaction of the particles, the particle deformation, the fluid flow and the particle motion. Published by Elsevier Ltd.
C1 US Army ARDEC, Technol Branch, Small Caliber Armaments Div, Picatinny Arsenal, NJ 07806 USA.
RP Florio, LA (reprint author), US Army ARDEC, Technol Branch, Small Caliber Armaments Div, Picatinny Arsenal, NJ 07806 USA.
EM laurie.a.florio.civ@mail.mil
FU ARDEC In-House Laboratory Independent Research Project; DoD High
Performance Computing Modernization Program at ARL; AFRL; ERDC
FX This work was funded by an ARDEC In-House Laboratory Independent
Research Project.; This work was supported in part by a grant of
computer time from the DoD High Performance Computing Modernization
Program at ARL, AFRL, and ERDC.
NR 47
TC 2
Z9 2
U1 0
U2 15
PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
PI LONDON
PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND
SN 0889-9746
J9 J FLUID STRUCT
JI J. Fluids Struct.
PD APR
PY 2015
VL 54
BP 171
EP 201
DI 10.1016/j.jfluidstructs.2014.10.014
PG 31
WC Engineering, Mechanical; Mechanics
SC Engineering; Mechanics
GA CH0SF
UT WOS:000353732000008
ER
PT J
AU Umthong, S
Buaklin, A
Jacquet, A
Sangjun, N
Kerdkaew, R
Patarakul, K
Palaga, T
AF Umthong, Supawadee
Buaklin, Arun
Jacquet, Alain
Sangjun, Noppadol
Kerdkaew, Ruthairat
Patarakul, Kanitha
Palaga, Tanapat
TI Immunogenicity of a DNA and Recombinant Protein Vaccine Combining LipL32
and Loa22 for Leptospirosis Using Chitosan as a Delivery System
SO JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY
LA English
DT Article
DE Leptospirosis; DNA vaccine; chitosan; immunogenicity
ID OUTER-MEMBRANE PROTEINS; T-CELL RESPONSES; TUBERCULOSIS VACCINE;
INTERROGANS; LIPOPROTEIN; INFECTION; IMMUNITY; SEROVAR; PRIME; BOOST
AB Leptospirosis is a worldwide zoonotic disease caused by pathogenic Leptospira, a genus of which more than 250 serovars have been identified. Commercial bacterin vaccines are limited in that they lack both cross-protection against heterologous serovars and long-term protection. This study investigated in mice the immunogenicity of an anti-leptospirosis vaccine, using the outer membrane proteins LipL32 and Loa22 as antigens. The immunogenicity of this vaccine formulation was compared with those induced by vaccines based on LipL32 or Loa22 alone. A DNA-encapsulated chitosan nanoparticle was used for in vivo DNA delivery. Using a unique DNA plasmid expressing both lipL32 and loa22 for vaccination, higher antibody responses were induced than when combining plasmids harboring each gene separately. Therefore, this formulation was used to test the immunogenicity when administered by a heterologous prime (DNA)-boost (protein) immunization regimen. The specific antibody responses against LipL32 (total IgG and IgG1) and Loa22 (IgG1) were higher in mice receiving two antigens in combination than in those vaccinated with a single antigen alone. Although no significant difference in splenic CD4(+) T cell proliferation was observed among all groups of vaccinated mice, splenocytes from mice vaccinated with two antigens exhibited higher interferon-gamma and IL-2 production than when using single antigens alone upon in vitro restimulation. Taken together, the immunogenicity induced by LipL32 and Loa22 antigens in a heterologous prime-boost immunization regimen using chitosan as a DNA delivery system induces higher immune response, and may be useful for developing a better vaccine for leptospirosis.
C1 [Umthong, Supawadee; Kerdkaew, Ruthairat; Patarakul, Kanitha; Palaga, Tanapat] Chulalongkorn Univ, Grad Sch, Interdisciplinary Program Med Microbiol, Bangkok 10330, Thailand.
[Buaklin, Arun; Patarakul, Kanitha] Chulalongkorn Univ, Fac Med, Dept Microbiol, Bangkok 10330, Thailand.
[Buaklin, Arun; Jacquet, Alain; Patarakul, Kanitha; Palaga, Tanapat] Chulalongkorn Univ, Vaccine Res Ctr, Bangkok 10330, Thailand.
[Jacquet, Alain] Chulalongkorn Univ, Fac Med, Dept Med, Bangkok 10330, Thailand.
[Sangjun, Noppadol] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand.
[Palaga, Tanapat] Chulalongkorn Univ, Dept Microbiol, Fac Sci, Bangkok 10330, Thailand.
RP Palaga, T (reprint author), Chulalongkorn Univ, Grad Sch, Interdisciplinary Program Med Microbiol, Bangkok 10330, Thailand.
EM kanitha.pa@chula.ac.th; tanapat.p@chula.ac.th
FU Higher Education Research Promotion; National Research University
Project of Thailand, Office of the Higher Education Commission
[HR1164A2]; Special Task Force for Activating Research (STAR) from the
Centenary Academic Development Project (Chulalongkorn University);
National Research Council of Thailand (NRCT); Research, Development and
Engineering (RD&E) fund through The National Nanotechnology Center
(NANOTEC); National Science and Technology Development Agency (NSTDA),
Thailand [P-10-10454]; Thai Government Stimulus Package 2 under the
Project for the Establishment of Innovative Food and Health Products and
Agriculture [TKK2555]; post-doctoral fellowship (Rachadapisek Sompote
Endowment Fund) from Chulalongkorn University Graduate School;
Development and Promotion of Science and Technology Talents Project
(DPST)
FX This work was supported by the Higher Education Research Promotion and
the National Research University Project of Thailand, Office of the
Higher Education Commission (HR1164A2), the Special Task Force for
Activating Research (STAR) from the Centenary Academic Development
Project (Chulalongkorn University), and the National Research Council of
Thailand (NRCT). The authors would like to acknowledge financial support
from the Research, Development and Engineering (RD&E) fund through The
National Nanotechnology Center (NANOTEC), the National Science and
Technology Development Agency (NSTDA), Thailand (Project No. P-10-10454)
to Chulalongkorn University. The equipment used in this study was
purchased with funds from the Thai Government Stimulus Package 2
(TKK2555) under the Project for the Establishment of Innovative Food and
Health Products and Agriculture. Arun Buaklin was sponsored by a
post-doctoral fellowship (Rachadapisek Sompote Endowment Fund) from
Chulalongkorn University Graduate School. Supawadee Umthong was
supported by the Development and Promotion of Science and Technology
Talents Project (DPST).
NR 40
TC 4
Z9 4
U1 4
U2 12
PU KOREAN SOC MICROBIOLOGY & BIOTECHNOLOGY
PI SEOUL
PA KOREA SCI TECHNOL CENTER #507, 635-4 YEOGSAM-DONG, KANGNAM-GU, SEOUL
135-703, SOUTH KOREA
SN 1017-7825
EI 1738-8872
J9 J MICROBIOL BIOTECHN
JI J. Microbiol. Biotechnol.
PD APR
PY 2015
VL 25
IS 4
BP 526
EP 536
DI 10.4014/jmb.1408.08007
PG 11
WC Biotechnology & Applied Microbiology; Microbiology
SC Biotechnology & Applied Microbiology; Microbiology
GA CG9TW
UT WOS:000353664000015
PM 25348693
ER
PT J
AU Reinke, EN
Bera, S
Diamond, AM
AF Reinke, Emily N.
Bera, Soumen
Diamond, Alan M.
TI Exposure of chronic myelogenous leukemia cells to imatinib results in
the post-transcriptional induction of manganese superoxide dismutase
SO LEUKEMIA & LYMPHOMA
LA English
DT Article
DE CML; MnSOD; innatinib; cell lines
ID CHRONIC MYELOID-LEUKEMIA; CML CELLS; RESISTANCE; CANCER
AB The treatment of chronic myelogenous leukemia (CML) with specific tyrosine kinase inhibitors typically results in clinical success, although therapeutic failure frequently occurs. In order to investigate the biological consequences of treating CML cells with such drugs, we previously reported that the antioxidant selenoprotein glutathione peroxidase-1 (GPx-1) was induced by imatinib in both patient samples and cultured cells. Here, we extend these findings to demonstrate that the treatment of CML cell lines, but not non-CML cells, results in an approximately four-fold increase in the levels of another important antioxidant protein, manganese superoxide dismutase (MnSOD), without altering the steady state levels of the corresponding transcript.
C1 [Reinke, Emily N.; Bera, Soumen; Diamond, Alan M.] Univ Illinois, Pathol, Chicago, IL USA.
RP Reinke, EN (reprint author), US Army Publ Hlth Command, Army Inst Publ Hlth, 5158 Blackhawk Rd ATTN MCHB IP THE, Aberdeen Proving Ground, MD 21010 USA.
EM emily.n.reinke.civ@mail.mil
FU National Institutes of Health (NIH) [R21CA129590]
FX This work was supported by a Grant from the National Institutes of
Health (NIH) #R21CA129590 to A.M.D.
NR 16
TC 0
Z9 0
U1 0
U2 0
PU INFORMA HEALTHCARE
PI LONDON
PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND
SN 1042-8194
EI 1029-2403
J9 LEUKEMIA LYMPHOMA
JI Leuk. Lymphoma
PD APR
PY 2015
VL 56
IS 4
BP 1096
EP 1099
DI 10.3109/10428194.2014.944521
PG 4
WC Oncology; Hematology
SC Oncology; Hematology
GA CG9CT
UT WOS:000353612700042
PM 25039350
ER
PT J
AU Brunye, TT
Mahoney, CR
Taylor, HA
AF Brunye, Tad T.
Mahoney, Caroline R.
Taylor, Holly A.
TI PATHS WITH MORE TURNS ARE PERCEIVED AS LONGER: MISPERCEPTIONS WITH
MAP-BASED AND ABSTRACTED PATH STIMULI
SO PERCEPTUAL AND MOTOR SKILLS
LA English
DT Article
ID SPATIAL MEMORY; COGNITIVE MAPS; DISTANCE COGNITION; TRAVERSED DISTANCE;
GENDER-DIFFERENCES; SEX-DIFFERENCES; PERCEPTION; DISTORTIONS; DIRECTION;
STRATEGIES
AB When navigating, people tend to overestimate distances when routes contain more turns, termed the route-angularity effect. Three experiments examined the source and generality of this effect. The first two experiments examined whether route-angularity effects occur while viewing maps and might be related to sex differences or sense of direction. The third experiment tested whether the route-angularity effect would occur with stimuli devoid of spatial context, reducing influences of environmental experience and visual complexity. In the three experiments, participants (N = 1,552; M = 32.2 yr.; 992 men, 560 women) viewed paths plotted on maps (Exps. 1 and 2) or against a blank background (Exp. 3). The depicted paths were always the same overall length, but varied in the number of turns (from 1 to 7) connecting an origin and destination. Participants were asked to estimate the time to traverse each path (Exp. 1) or the length of each path (Exps. 2 and 3). The Santa Barbara Sense of Direction questionnaire was administered to assess whether overall spatial sense of direction would be negatively related to the magnitude of the route-angularity effect. Repeated-measures analyses of variance (ANOVAs) indicated that paths with more turns elicited estimates of greater distance and travel times, whether they were depicted on maps or blank backgrounds. Linear regressions also indicated that these effects were significantly larger in those with a relatively low sense of direction. The results support the route-angularity effect and extend it to paths plotted on map-based stimuli. Furthermore, because the route-angularity effect was shown with paths plotted against blank backgrounds, route-angularity effects are not specific to understanding environments and may arise at the level of visual perception.
C1 [Brunye, Tad T.; Mahoney, Caroline R.] US Army, Natick Soldier Res Dev & Engn Ctr, Cognit Sci Team, Natick, MA 01760 USA.
[Brunye, Tad T.; Mahoney, Caroline R.; Taylor, Holly A.] Tufts Univ, Dept Psychol, Medford, MA USA.
RP Brunye, TT (reprint author), US Army, NSRDEC, Attn RDNS WSH S,15 Kansas St, Natick, MA 01760 USA.
EM tbruny01@tufts.edu
FU U.S. Army Natick Soldier Research, Development, and Engineering Center
[W911QY13C0012]
FX This work was supported by the U.S. Army Natick Soldier Research,
Development, and Engineering Center (Grant Number W911QY13C0012).
NR 57
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PU AMMONS SCIENTIFIC, LTD
PI MISSOULA
PA PO BOX 9229, MISSOULA, MT 59807-9229 USA
SN 0031-5125
J9 PERCEPT MOTOR SKILL
JI Percept. Mot. Skills
PD APR
PY 2015
VL 120
IS 2
BP 438
EP 461
DI 10.2466/22.PMS.120v11x2
PG 24
WC Psychology, Experimental
SC Psychology
GA CG8OD
UT WOS:000353566700007
PM 25799028
ER
PT J
AU Hurley, KA
Heinrich, VA
Hershfield, JR
Demons, ST
Weibel, DB
AF Hurley, Katherine A.
Heinrich, Victoria A.
Hershfield, Jeremy R.
Demons, Samandra T.
Weibel, Douglas B.
TI Membrane-Targeting DCAP Analogues with Broad-Spectrum Antibiotic
Activity against Pathogenic Bacteria
SO ACS MEDICINAL CHEMISTRY LETTERS
LA English
DT Article
DE Antibiotic; chemotherapeutic; antimicrobial; bacterial membrane;
broad-spectrum activity
ID ESCHERICHIA-COLI; IDENTIFICATION; NOVOBIOCIN; INHIBITORS; GYRASE
AB We performed a structure activity relationship study of 2-((3-(3,6-dichloro-9H-carbazol-9-yl)-2-hydroxypropyl)amino)-2-(hydroxymethyl)propane-1,3-diol (DCAP), which is an antibacterial agent that disrupts the membrane potential and permeability of bacteria. The stereochemistry of DCAP had no effect on the biological activity of DCAP. The aromaticity and electronegativity of the chlorine-substituted carbazole was required for activity, suggesting that its planar and dipolar characteristics orient DCAP in membranes. Increasing the hydrophobicity of the tail region of DCAP enhanced its antibiotic activity. Two DCAP analogues displayed promising antibacterial activity against the BSL-3 pathogens Bacillus anthracis and Francisella tularensis. Codosing DCAP analogues with ampicillin or kanamycin increased their potency. These studies demonstrate that DCAP and its analogues may be a promising scaffold for developing chemotherapeutic agents that bind to bacterial membranes and kill strains of slow-growing or dormant bacteria that cause persistent infections.
C1 [Hurley, Katherine A.; Heinrich, Victoria A.; Weibel, Douglas B.] Univ Wisconsin, Dept Biochem, Madison, WI 53706 USA.
[Weibel, Douglas B.] Univ Wisconsin, Dept Chem, Madison, WI 53706 USA.
[Hershfield, Jeremy R.; Demons, Samandra T.] US Army Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA.
RP Weibel, DB (reprint author), Univ Wisconsin, Dept Biochem, Madison, WI 53706 USA.
EM weibel@biochem.wisc.edu
FU National Institutes of Health [1DP2OD008735]; Human Frontiers Science
Program [RGY0076/2013]; Defense Threat Reduction Agency under USAMRIID
[922141]; American Foundation for Pharmaceutical Education (AFPE)
FX This research was supported by grants from the National Institutes of
Health (1DP2OD008735), the Human Frontiers Science Program
(RGY0076/2013), and Defense Threat Reduction Agency under USAMRIID
(Proj. #922141). K.A.H. acknowledges a fellowship from the American
Foundation for Pharmaceutical Education (AFPE).
NR 25
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PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 1948-5875
J9 ACS MED CHEM LETT
JI ACS Med. Chem. Lett.
PD APR
PY 2015
VL 6
IS 4
BP 466
EP 471
DI 10.1021/acsmedchemlett.5b00024
PG 6
WC Chemistry, Medicinal
SC Pharmacology & Pharmacy
GA CG2IO
UT WOS:000353098300019
PM 25941556
ER
PT J
AU Samy, RP
Thwin, MM
Stiles, BG
Satyanarayana-Jois, S
Chinnathambi, A
Zayed, ME
Alharbi, SA
Siveen, KS
Sikka, S
Kumar, AP
Sethi, G
Lim, LHK
AF Samy, Ramar Perumal
Thwin, Maung Maung
Stiles, Brad G.
Satyanarayana-Jois, Seetharama
Chinnathambi, Arunachalam
Zayed, M. E.
Alharbi, Sulaiman Ali
Siveen, Kodappully Sivaraman
Sikka, Sakshi
Kumar, Alan Prem
Sethi, Gautam
Lim, Lina Hsiu Kim
TI Novel phospholipase A(2) inhibitors from python serum are potent peptide
antibiotics
SO BIOCHIMIE
LA English
DT Article
DE Phospholipase A(2) inhibitory peptide (PLI); Bacteria; Python serum;
Antibacterial; Multi-drug resistance
ID SOFT-TISSUE INFECTIONS; PLATELET-AGGREGATION INHIBITOR; ALTERNATUS
SNAKE-VENOM; GROWTH-FACTOR-BETA; NF-KAPPA-B; ANTIMICROBIAL PEPTIDES;
BOTHROPS-JARARACUSSU; ANTIINFLAMMATORY ACTIVITY; STAPHYLOCOCCUS-AUREUS;
NONVENOMOUS SNAKE
AB Antimicrobial peptides (AMPs) play a vital role in defense against resistant bacteria. In this study, eight different AMPs synthesized from Python reticulatus serum protein were tested for bactericidal activity against various Gram-positive and Gram-negative bacteria (Staphylococcus aureus, Burkholderia pseudomallei (KHW and TES strains), and Proteus vulgaris) using a disc-diffusion method (20 mu g/disc). Among the tested peptides, phospholipase A(2) inhibitory peptide (PIP)-18[59-76], beta-Asp65-PIP[59-67], D-Ala66-PNT.II, and D60,65E-PIP[59-67] displayed the most potent bactericidal activity against all tested pathogens in a dose-dependent manner (100-6.8 mu g/ml), with a remarkable activity noted against S. aureus at 6.8 mu g/ml dose within 6 h of incubation. Determination of minimum inhibitory concentrations (MICs) by a micro-broth dilution method at 100-3.125 mu g/ml revealed that PIP-18[59-76], beta-Asp65-PIP[59-67] and D-Ala66-PNT.II peptides exerted a potent inhibitory effect against S. aureus and B. pseudomallei (KHW) (MICs 3.125 mu g/ml), while a much less inhibitory potency (MICs 12.5 mu g/ml) was noted for beta-Asp65-PIP[59-67] and D-Ala66-PNT.II peptides against B. pseudomallei (TES). Higher doses of peptides had no effect on the other two strains (i.e., Klebsiella pneumoniae and Streptococcus pneumoniae). Overall, PIP-18[59-76] possessed higher antimicrobial activity than that of chloramphenicol (CHL), ceftazidime (CF) and streptomycin (ST) (30 mu g/disc). When the two most active peptides, PIP-18[59-76] and beta-Asp65-PIP[59-67], were applied topically at a 150 mg/kg dose for testing wound healing activity in a mouse model of S. aureus infection, the former accelerates faster wound healing than the latter peptide at 14 days post-treatment. The western blot data suggest that the topical application of peptides (PIP-18 [59-67] and beta-Asp65-PIP[59-67]) modulates NF-kB mediated wound repair in mice with relatively little haemolytic (100-1.56 mu g/ml) and cytotoxic (1000-3.125 mu g/ml) effects evident on human cells in vitro. (C) 2015 Published by Elsevier B.V.
C1 [Samy, Ramar Perumal; Thwin, Maung Maung] Natl Univ Singapore, Venom & Toxin Res Programme, Yong Loo Lin Sch Med, Dept Anat,Natl Univ Hlth Syst, Singapore 117597, Singapore.
[Samy, Ramar Perumal] Natl Univ Singapore, Yong Loo Lin Sch Med, Natl Univ Hlth Syst, Dept Microbiol, Singapore 117597, Singapore.
[Samy, Ramar Perumal; Lim, Lina Hsiu Kim] Natl Univ Singapore, Dept Physiol, NUHS, Ctr Life Sci,Yong Loo Lin Sch Med, Singapore 117456, Singapore.
[Stiles, Brad G.] US Army, Integrated Toxicol Div, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA.
[Stiles, Brad G.] Wilson Coll, Dept Biol, Chambersburg, PA 17201 USA.
[Satyanarayana-Jois, Seetharama] Univ Louisiana Monroe, Dept Basic Pharmaceut Sci, Sch Pharm, Monroe, LA 71291 USA.
[Chinnathambi, Arunachalam; Zayed, M. E.; Alharbi, Sulaiman Ali; Sethi, Gautam] King Saud Univ, Coll Sci, Dept Bot & Microbiol, Riyadh 11451, Saudi Arabia.
[Siveen, Kodappully Sivaraman; Kumar, Alan Prem; Sethi, Gautam] NUS, Dept Pharmacol, Yong Loo Lin Sch Med, Singapore, Singapore.
[Sikka, Sakshi; Kumar, Alan Prem] Canc Sci Inst Singapore, Singapore, Singapore.
[Kumar, Alan Prem] Natl Univ Canc Inst, Singapore, Singapore.
[Kumar, Alan Prem] Curtin Univ, Fac Hlth Sci, Sch Biomed Sci, Bentley, WA, Australia.
[Kumar, Alan Prem] Univ N Texas, Dept Biol Sci, Denton, TX 76203 USA.
RP Samy, RP (reprint author), Natl Univ Singapore, Dept Physiol, NUS Immunol Programme, Ctr Life Sci,Yong Loo Lin Sch Med, Singapore 117456, Singapore.
EM rperumalsamy@yahoo.co.uk
RI Chinnathambi, Arunachalam/E-7808-2016;
OI Chinnathambi, Arunachalam/0000-0002-7126-8421; Lim,
Lina/0000-0002-2935-2275
FU NUHS Bench-to- Bedside-To-Product grant [R-184-000-242-515]; Deanship of
Scientific Research, College of Sciences Research Center, King Saud
University, Kingdom of Saudi under The Visiting Professor Program
FX This work was supported by NUHS Bench-to- Bedside-To-Product grant
(R-184-000-242-515) to GS. GS will also like to thank Deanship of
Scientific Research, College of Sciences Research Center, King Saud
University, Kingdom of Saudi for awarding the Visiting Professorship
under The Visiting Professor Program.
NR 90
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PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI PARIS
PA 23 RUE LINOIS, 75724 PARIS, FRANCE
SN 0300-9084
EI 1638-6183
J9 BIOCHIMIE
JI Biochimie
PD APR
PY 2015
VL 111
BP 30
EP 44
DI 10.1016/j.biochi.2015.01.003
PG 15
WC Biochemistry & Molecular Biology
SC Biochemistry & Molecular Biology
GA CG3KE
UT WOS:000353178300004
PM 25583073
ER
PT J
AU Guevarra, CS
Borke, JL
Stevens, MR
Bisch, FC
Zakhary, I
Messer, R
Gerlach, RC
Elsalanty, ME
AF Guevarra, Chestine S.
Borke, James L.
Stevens, Mark R.
Bisch, Fredrick C.
Zakhary, Ibrahim
Messer, Regina
Gerlach, Robert C.
Elsalanty, Mohammed E.
TI Vascular Alterations in the Sprague-Dawley Rat Mandible During
Intravenous Bisphosphonate Therapy
SO Journal of Oral Implantology
LA English
DT Article
DE bisphosphonate; BRONJ; vascular parameters; rat model; mandible
ID SERUM CTX; ZOLEDRONIC ACID; CANCER-PATIENTS; OSTEONECROSIS; JAWS;
PREVENTION; LESIONS; RISK
AB Long-term use of intravenous bisphosphonates, such as zoledronic acid (zoledronate), has been linked to bisphosphonate-related osteonecrosis of the jaw (BRONJ). Invasive dental surgery seems to trigger the bone necrosis in most cases. To determine the effects of zoledronic acid on the vascular structure of the rat mandible. Extracted of the mandibular first molar in rats that received 2 IV injections of zoledronate (20 mu g/kg), 4 weeks apart. Zoledronate-treated rats (n = 18) were then compared to a control group of untreated rats (n = 18). At the fourth, eighth, and 12th week after molar extraction, 8 rat mandibles from each group were perfused with 35% radiopaque triphenylbismuth in methyl methacrylate via carotid artery perfusion. Mandibles were harvested and examined by micro-CT to assess the spatial and dimensional changes of the vasculature as a result of zoledronate treatment. The micro-CT analysis showed that zoledronic acid-treated rats had blood vessels that were thicker, less connected, and less ordered than control rats that were not exposed to zoledronic acid. This study demonstrated that treatment with zoledronic acid in rats is associated with vascular changes in alveolar bone. Further studies are underway to explore whether these vascular changes contribute to the pathogenesis of BRONJ.
C1 [Guevarra, Chestine S.; Zakhary, Ibrahim; Messer, Regina; Elsalanty, Mohammed E.] Georgia Regents Univ, Dept Oral Biol, Augusta, GA 30912 USA.
[Guevarra, Chestine S.; Bisch, Fredrick C.; Gerlach, Robert C.] US Army, Adv Educ Program Periodont, Ft Gordon, GA USA.
[Borke, James L.] Western Univ Hlth Sci, Coll Dent Med, Pomona, CA USA.
[Stevens, Mark R.] Georgia Regents Univ, Dept Oral & Maxillofacial Surg, Augusta, GA USA.
RP Elsalanty, ME (reprint author), Georgia Regents Univ, Dept Oral Biol, Augusta, GA 30912 USA.
EM melsalanty@gru.edu
FU AO Foundation, Davos, Switzerland; American Academy of Implant Dentistry
(AAID) Research Foundation, Chicago, IL; U.S. Army Advanced Education
Program in Periodontics, Fort Gordon, GA
FX This work was supported by the AO Foundation, Davos, Switzerland (JLB);
the American Academy of Implant Dentistry (AAID) Research Foundation,
Chicago, IL (JLB); and the U.S. Army Advanced Education Program in
Periodontics, Fort Gordon, GA (CSG & JLB). The views expressed in this
article are those of the authors and are not to be construed as official
or as reflecting the views of the U.S. Army or Department of Defense.
NR 22
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PU ALLEN PRESS INC
PI LAWRENCE
PA 810 E 10TH ST, LAWRENCE, KS 66044 USA
SN 0160-6972
EI 1548-1336
J9 J ORAL IMPLANTOL
JI J. Oral Implant.
PD APR
PY 2015
VL 41
IS 2
BP E24
EP E29
DI 10.1563/AAID-JOI-D-13-00074
PG 6
WC Dentistry, Oral Surgery & Medicine
SC Dentistry, Oral Surgery & Medicine
GA CG5BD
UT WOS:000353303000005
PM 24295432
ER
PT J
AU DuMars, T
Bolton, K
Maleku, A
Smith-Osborne, A
AF DuMars, Tyler
Bolton, Kristin
Maleku, Arati
Smith-Osborne, Alexa
TI Training MSSW Students for Military Social Work Practice and Doctoral
Students in Military Resilience Research
SO JOURNAL OF SOCIAL WORK EDUCATION
LA English
DT Article
ID VETERANS; CALL
AB The demand for social workers with military-related practice and research experience exceeds the current supply. To advance military social work education, we developed an interlevel master's of science in social work (MSSW) field practicum and doctoral research practicum that provides military social work field experiences and contributes to doctoral education on military intervention research. Tasked with the primary responsibility of teaching complex resilience concepts to youth participants, the project challenges MSSW students to develop deep knowledge of the material. Assigned the role of project manager of an ongoing intervention study and responsible for performing multiple hands-on research tasks, the project promotes doctoral student research proficiency. Feedback from students suggests that the project supports learning outcomes and enhances motivation to engage in present and future intervention research.
C1 [DuMars, Tyler] US Army, Washington, DC USA.
[Bolton, Kristin] Univ N Carolina Wilmington, Wilmington, NC USA.
[Maleku, Arati; Smith-Osborne, Alexa] Univ Texas Arlington, Ctr Clin Social Work, Arlington, TX 76019 USA.
[Smith-Osborne, Alexa] Univ Texas Arlington, Arlington, TX 76019 USA.
[Smith-Osborne, Alexa] Univ Texas Arlington, Student Vet Project, Arlington, TX 76019 USA.
RP DuMars, T (reprint author), Univ Texas Arlington, Sch Social Work, 211 South Cooper St,Box 19129, Arlington, TX 76019 USA.
EM tyler.d.dumars.mil@mail.mil
NR 30
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Z9 0
U1 1
U2 3
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND
SN 1043-7797
EI 2163-5811
J9 J SOC WORK EDUC
JI J. Soc. Work Educ.
PD APR 1
PY 2015
VL 51
SU 1
SI SI
BP S117
EP S127
DI 10.1080/10437797.2015.1001294
PG 11
WC Education & Educational Research; Social Work
SC Education & Educational Research; Social Work
GA CG7RA
UT WOS:000353500900009
ER
PT J
AU Welch, M
AF Welch, Michael
TI On the Ethics of Torture
SO PUNISHMENT & SOCIETY-INTERNATIONAL JOURNAL OF PENOLOGY
LA English
DT Book Review
C1 [Welch, Michael] Rutgers State Univ, USA, New Brunswick, NJ USA.
[Welch, Michael] Rutgers State Univ, Piscataway, NJ 08855 USA.
RP Welch, M (reprint author), Rutgers State Univ, Piscataway, NJ 08855 USA.
NR 1
TC 1
Z9 1
U1 0
U2 0
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1462-4745
EI 1741-3095
J9 PUNISHM SOC
JI Punishm. Soc.
PD APR
PY 2015
VL 17
IS 2
BP 261
EP 262
DI 10.1177/1462474514536370
PG 2
WC Criminology & Penology
SC Criminology & Penology
GA CG1OL
UT WOS:000353042500007
ER
PT J
AU Wolf, JC
Baumgartner, WA
Blazer, VS
Camus, AC
Engelhardt, JA
Fournie, JW
Frasca, S
Groman, DB
Kent, ML
Khoo, LH
Law, JM
Lombardini, ED
Ruehl-Fehlert, C
Segner, HE
Smith, SA
Spitsbergen, JM
Weber, K
Wolfe, MJ
AF Wolf, Jeffrey C.
Baumgartner, Wes A.
Blazer, Vicki S.
Camus, Alvin C.
Engelhardt, Jeffery A.
Fournie, John W.
Frasca, Salvatore, Jr.
Groman, David B.
Kent, Michael L.
Khoo, Lester H.
Law, Jerry M.
Lombardini, Eric D.
Ruehl-Fehlert, Christine
Segner, Helmut E.
Smith, Stephen A.
Spitsbergen, Jan M.
Weber, Klaus
Wolfe, Marilyn J.
TI Nonlesions, Misdiagnoses, Missed Diagnoses, and Other Interpretive
Challenges in Fish Histopathology Studies: A Guide for Investigators,
Authors, Reviewers, and Readers
SO TOXICOLOGIC PATHOLOGY
LA English
DT Article
DE artifacts; diagnostic accuracy; fish histopathology; nonlesions; tissue
fixation; misdiagnosis
ID TROUT ONCORHYNCHUS-MYKISS; PATHOLOGY WORKING GROUP; RAINBOW-TROUT;
OREOCHROMIS-NILOTICUS; NILE TILAPIA; TOXICITY; CRITERIA; LESIONS; SITE;
GILLS
AB Differentiating salient histopathologic changes from normal anatomic features or tissue artifacts can be decidedly challenging, especially for the novice fish pathologist. As a consequence, findings of questionable accuracy may be reported inadvertently, and the potential negative impacts of publishing inaccurate histopathologic interpretations are not always fully appreciated. The objectives of this article are to illustrate a number of specific morphologic findings in commonly examined fish tissues (e.g., gills, liver, kidney, and gonads) that are frequently either misdiagnosed or underdiagnosed, and to address related issues involving the interpretation of histopathologic data. To enhance the utility of this article as a guide, photomicrographs of normal and abnormal specimens are presented. General recommendations for generating and publishing results from histopathology studies are additionally provided. It is hoped that the furnished information will be a useful resource for manuscript generation, by helping authors, reviewers, and readers to critically assess fish histopathologic data.
C1 [Wolf, Jeffrey C.; Wolfe, Marilyn J.] Expt Pathol Labs Inc, Sterling, VA USA.
[Baumgartner, Wes A.] Coll Vet Med, Dept Pathobiol Populat Med, Mississippi State, MS USA.
[Blazer, Vicki S.] US Geol Survey, Kearneysville, WV USA.
[Camus, Alvin C.] Univ Georgia, Coll Vet Med, Dept Pathol, Athens, GA 30602 USA.
[Engelhardt, Jeffery A.] Expt Pathol Labs Inc, Camarillo, CA USA.
[Fournie, John W.] US EPA, Natl Hlth & Environm Effects Res Lab, Gulf Ecol Div, Gulf Breeze, FL USA.
[Frasca, Salvatore, Jr.] Univ Connecticut, Dept Pathobiol & Vet Sci, Connecticut Vet Med Diagnost Lab, Storrs, CT USA.
[Groman, David B.] Univ Prince Edward Isl, Atlantic Vet Coll, Aquat Diagnost Serv, Charlottetown, PE C1A 4P3, Canada.
[Kent, Michael L.] Oregon State Univ, Dept Microbiol, Corvallis, OR 97331 USA.
[Kent, Michael L.] Oregon State Univ, Dept Biomed Sci, Corvallis, OR 97331 USA.
[Khoo, Lester H.] Mississippi State Univ, Coll Vet Med, Stoneville, MS USA.
[Law, Jerry M.] N Carolina State Univ, Coll Vet Med, Aquat Ecotoxicol, Raleigh, NC USA.
[Lombardini, Eric D.] Armed Forces Res Inst Med Sci, Dept Vet Med, Div Comparat Pathol, Bangkok 10400, Thailand.
[Lombardini, Eric D.] Armed Forces Res Inst Med Sci, Dept Vet Med, Div Vet Med Res, Bangkok 10400, Thailand.
[Ruehl-Fehlert, Christine] Bayer HealthCare, Wuppertal, Germany.
[Segner, Helmut E.] Univ Bern, Ctr Fish & Wildlife Hlth, Bern, Switzerland.
[Smith, Stephen A.] Virginia Tech, Virginia Maryland Reg Coll Vet Med, Blacksburg, VA USA.
[Spitsbergen, Jan M.] Oregon State Univ, Dept Microbiol, Fish Dis Res Grp, Corvallis, OR 97331 USA.
[Weber, Klaus] AnaPath GmbH, Oberbuchsiten, Switzerland.
RP Wolf, JC (reprint author), 45600 Terminal Dr, Sterling, VA 20166 USA.
EM jwolf@epl-inc.com
NR 42
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U1 2
U2 12
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0192-6233
EI 1533-1601
J9 TOXICOL PATHOL
JI Toxicol. Pathol.
PD APR
PY 2015
VL 43
IS 3
BP 297
EP 325
DI 10.1177/0192623314540229
PG 29
WC Pathology; Toxicology
SC Pathology; Toxicology
GA CG3AN
UT WOS:000353148900001
PM 25112278
ER
PT J
AU Faran, ME
Johnson, PL
Ban, P
Shue, T
Weist, MD
AF Faran, Michael E.
Johnson, Patti L.
Ban, Paul
Shue, Tracy
Weist, Mark D.
TI The Evolution of a School Behavioral Health Model in the US Army
SO CHILD AND ADOLESCENT PSYCHIATRIC CLINICS OF NORTH AMERICA
LA English
DT Article
DE School behavioral health; US Army; Child and family behavioral health
system; Military children
ID MILITARY TREATMENT FACILITY; MENTAL-HEALTH; CHILD MALTREATMENT;
DEPLOYMENT; FAMILIES; CARE; SERVICES; YOUTH
AB The US Army has developed an innovative School Behavioral Health (SBH) program, part of the Child and Family Behavioral Health System, a collaborative, consultative behavioral health care model that includes SBH, standardized training of primary care providers in treatment of common behavioral health problems, use of tele-consultation/tele-behavioral health, optimizing community outreach services, and integration with other related behavioral health services. In this article, the needs of military children, adolescents, and families are reviewed, a history of this initiative is presented, key themes are discussed, and next steps in advancing this evolving, innovative system of health care featuring SBH are described.
C1 [Faran, Michael E.; Johnson, Patti L.; Ban, Paul; Shue, Tracy] US Army, Med Command, Child & Family Behav Hlth Off, Tacoma, WA 98431 USA.
[Weist, Mark D.] Univ S Carolina, Dept Psychol, Columbia, SC 29208 USA.
RP Faran, ME (reprint author), US Army, Med Command, Child & Family Behav Hlth Off, 9913-A Madigan Annex, Tacoma, WA 98431 USA.
EM michael.e.faran.civ@mail.mil
NR 41
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PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 1056-4993
EI 1558-0490
J9 CHILD ADOL PSYCH CL
JI Child Adolesc. Psychiatr. N. Am.
PD APR
PY 2015
VL 24
IS 2
BP 415
EP +
DI 10.1016/j.chc.2014.11.008
PG 15
WC Psychiatry
SC Psychiatry
GA CF6IT
UT WOS:000352661100015
PM 25773333
ER
PT J
AU Glynn, AR
Alves, DA
Frick, O
Erwin-Cohen, R
Porter, A
Norris, S
Waag, D
Nalca, A
AF Glynn, Audrey R.
Alves, Derron A.
Frick, Ondraya
Erwin-Cohen, Rebecca
Porter, Aimee
Norris, Sarah
Waag, David
Nalca, Aysegul
TI Comparison of experimental respiratory tularemia in three nonhuman
primate species
SO COMPARATIVE IMMUNOLOGY MICROBIOLOGY AND INFECTIOUS DISEASES
LA English
DT Article
DE Francisella tularensis; Tularemia; Aerosol; Inhalation; Nonhuman
primate; Animal model
ID FRANCISELLA-TULARENSIS; BIOLOGICAL WARFARE; MONKEYS
AB Tularemia is a zoonotic disease caused by Francisella tularensis, which is transmitted to humans most commonly by contact with infected animals, tick bites, or inhalation of aerosolized bacteria. F. tularensis is highly infectious via the aerosol route; inhalation of as few as 10-50 organisms can cause pneumonic tularemia. Left untreated, the pneumonic form has more than >30% case-fatality rate but with early antibiotic intervention can be reduced to 3%. This study compared tularemia disease progression across three species of nonhuman primates [African green monkey (AGM), cynomolgus macaque (CM), and rhesus macaque (RM)] following aerosolized F. tularensis Schu S4 exposure. Groups of the animals exposed to various challenge doses were observed for clinical signs of infection and blood samples were analyzed to characterize the disease pathogenesis. Whereas the AGMs and CMs succumbed to disease following challenge doses of 40 and 32 colony forming units (CFU), respectively, the RM lethal dose was 276,667 CFU. Following all challenge doses that caused disease, the NHPs experienced weight loss, bacteremia, fever as early as 4 days post exposure, and tissue burden. Necrotizing-to-pyogranulomatous lesions were observed most commonly in the lung, lymph nodes, spleen, and bone marrow. Overall, the CM model consistently manifested pathological responses similar to those resulting from inhalation of F. tularensis in humans and thereby most closely emulates human tularemia disease. The RM model displayed a higher tolerance to infection and survived exposures of up to 15,593 CFU of aerosolized F. tularensis. Published by Elsevier Ltd.
C1 [Glynn, Audrey R.; Frick, Ondraya; Erwin-Cohen, Rebecca; Porter, Aimee; Nalca, Aysegul] US Army, Ctr Aerobiol Sci, Med Res Inst Infect Dis, Frederick, MD 21702 USA.
[Alves, Derron A.] US Army, Div Pathol, Med Res Inst Infect Dis, Frederick, MD 21702 USA.
[Norris, Sarah] US Army, Div Biostat, Med Res Inst Infect Dis, Frederick, MD 21702 USA.
[Waag, David] US Army, Bacteriol Div, Med Res Inst Infect Dis, Frederick, MD 21702 USA.
RP Nalca, A (reprint author), US Army, Med Inst Infect Dis, 1425 Porter St, Frederick, MD 21702 USA.
EM aysegul.nalca@us.army.mil
FU Office of Biodefense, Research Resources and Translational Research
(OBRRTR); USAMRIID
FX This study was supported by an interagency agreement between The Office
of Biodefense Research Affairs (OBRA)/National Institute of Allergy and
Infectious Diseases (NIAID) (now known as Office of Biodefense, Research
Resources and Translational Research (OBRRTR) and USAMRIID.
NR 12
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U1 0
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PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0147-9571
EI 1878-1667
J9 COMP IMMUNOL MICROB
JI Comp. Immunol. Microbiol. Infect. Dis.
PD APR
PY 2015
VL 39
BP 13
EP 24
DI 10.1016/j.cimid.2015.01.003
PG 12
WC Immunology; Microbiology; Veterinary Sciences
SC Immunology; Microbiology; Veterinary Sciences
GA CF9VZ
UT WOS:000352916600003
PM 25766142
ER
PT J
AU Mendoza, PA
Clark, MP
Mizukami, N
Newman, AJ
Barlage, M
Gutmann, ED
Rasmussen, RM
Rajagopalan, B
Brekke, LD
Arnold, JR
AF Mendoza, Pablo A.
Clark, Martyn P.
Mizukami, Naoki
Newman, Andrew J.
Barlage, Michael
Gutmann, Ethan D.
Rasmussen, Roy M.
Rajagopalan, Balaji
Brekke, Levi D.
Arnold, Jeffrey R.
TI Effects of Hydrologic Model Choice and Calibration on the Portrayal of
Climate Change Impacts
SO JOURNAL OF HYDROMETEOROLOGY
LA English
DT Article
DE Watersheds; Climate change; Hydrologic cycle; Hydrologic models; Model
comparison; Model evaluation; performance
ID COLORADO RIVER-BASIN; LAND-SURFACE MODEL; WINTER PRECIPITATION;
SPATIAL-RESOLUTION; CHANGE SCENARIOS; WATER-BALANCE; UNITED-STATES;
NORTH-AMERICA; STREAMFLOW; RUNOFF
AB The assessment of climate change impacts on water resources involves several methodological decisions, including choices of global climate models (GCMs), emission scenarios, downscaling techniques, and hydrologic modeling approaches. Among these, hydrologic model structure selection and parameter calibration are particularly relevant and usually have a strong subjective component. The goal of this research is to improve understanding of the role of these decisions on the assessment of the effects of climate change on hydrologic processes. The study is conducted in three basins located in the Colorado headwaters region, using four different hydrologic model structures [PRMS, VIC, Noah LSM, and Noah LSM with multiparameterization options (Noah-MP)]. To better understand the role of parameter estimation, model performance and projected hydrologic changes (i.e., changes in the hydrology obtained from hydrologic models due to climate change) are compared before and after calibration with the University of Arizona shuffled complex evolution (SCE-UA) algorithm. Hydrologic changes are examined via a climate change scenario where the Community Climate System Model (CCSM) change signal is used to perturb the boundary conditions of the Weather Research and Forecasting (WRF) Model configured at 4-km resolution. Substantial intermodel differences (i.e., discrepancies between hydrologic models) in the portrayal of climate change impacts on water resources are demonstrated. Specifically, intermodel differences are larger than the mean signal from the CCSM-WRF climate scenario examined, even after the calibration process. Importantly, traditional single-objective calibration techniques aimed to reduce errors in runoff simulations do not necessarily improve intermodel agreement (i.e., same outputs from different hydrologic models) in projected changes of some hydrological processes such as evapotranspiration or snowpack.
C1 [Mendoza, Pablo A.; Rajagopalan, Balaji] Univ Colorado, Dept Civil Environm & Architectural Engn, Boulder, CO 80309 USA.
[Mendoza, Pablo A.; Rajagopalan, Balaji] Univ Colorado, Cooperat Inst Res Environm Sci, Boulder, CO 80309 USA.
[Mendoza, Pablo A.; Clark, Martyn P.; Mizukami, Naoki; Newman, Andrew J.; Barlage, Michael; Gutmann, Ethan D.; Rasmussen, Roy M.] Natl Ctr Atmospher Res, Res Applicat Lab, Boulder, CO 80307 USA.
[Brekke, Levi D.] US Bur Reclamat, Denver, CO 80225 USA.
[Arnold, Jeffrey R.] US Army Corps Engineers, Seattle, WA USA.
RP Mendoza, PA (reprint author), Univ Colorado, Dept Civil Environm & Architectural Engn, UCB 428, Boulder, CO 80309 USA.
EM pmendoza@colorado.edu
RI Clark, Martyn/A-5560-2015; Rajagopalan, Balaji/A-5383-2013; Gutmann,
Ethan/I-5728-2012
OI Clark, Martyn/0000-0002-2186-2625; Rajagopalan,
Balaji/0000-0002-6883-7240; Gutmann, Ethan/0000-0003-4077-3430
FU Bureau of Reclamation (USBR); U.S. Army Corps of Engineers (USACE);
Cooperative Institute for Research and Environmental Sciences (CIRES)
FX The authors thank Kyoko Ikeda for her help with WRF reanalysis datasets.
We are grateful to Marketa Elsner, Roland Viger, Adam Carheden, and Tor
Mohling for their advice and assistance for setting up the models. We
also thank Olda Rakovec and Mary Hill for their help with the
implementation of DELSA. This study was supported through a cooperative
agreement with the Bureau of Reclamation (USBR), through a contract from
the U.S. Army Corps of Engineers (USACE), and through a graduate
fellowship from the Cooperative Institute for Research and Environmental
Sciences (CIRES).
NR 79
TC 12
Z9 12
U1 8
U2 40
PU AMER METEOROLOGICAL SOC
PI BOSTON
PA 45 BEACON ST, BOSTON, MA 02108-3693 USA
SN 1525-755X
EI 1525-7541
J9 J HYDROMETEOROL
JI J. Hydrometeorol.
PD APR
PY 2015
VL 16
IS 2
BP 762
EP 780
DI 10.1175/JHM-D-14-0104.1
PG 19
WC Meteorology & Atmospheric Sciences
SC Meteorology & Atmospheric Sciences
GA CF7KM
UT WOS:000352735100019
ER
PT J
AU Boghardt, T
AF Boghardt, Thomas
TI Dirty Work? The Use of Nazi Informants by US Army Intelligence in
Postwar Europe
SO JOURNAL OF MILITARY HISTORY
LA English
DT Article
AB After World War II ended in 1945, U.S. Army intelligence agencies, especially the Counter Intelligence Corps, recruited former Nazi officials, war crimes suspects, and war criminals to collect information on communist party and Soviet activities in Europe. While studies have examined individual cases, this article seeks to establish the historical context of the early Cold War that set the framework for this intelligence exploitation. It also weighs the intelligence value of the Army's Nazi informants and reviews recruitment by other American and Allied intelligence services. Finally, it discusses the challenges of using ethical guidelines in recruiting secret agents, during the early Cold War and beyond.
C1 US Army Ctr Mil Hist, Washington, DC 20374 USA.
RP Boghardt, T (reprint author), US Army Ctr Mil Hist, Washington, DC 20374 USA.
NR 106
TC 0
Z9 0
U1 0
U2 1
PU SOC MILITARY HISTORY
PI LEXINGTON
PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA
24450-1600 USA
SN 0899-3718
EI 1543-7795
J9 J MILITARY HIST
JI J. Mil. Hist.
PD APR
PY 2015
VL 79
IS 2
BP 387
EP 422
PG 36
WC History
SC History
GA CF9YA
UT WOS:000352922600005
ER
PT J
AU Donnelly, WM
AF Donnelly, William M.
TI "This 'Horrible Example'": An Extraordinary Case of Absent Without Leave
during the Vietnam War
SO JOURNAL OF MILITARY HISTORY
LA English
DT Article
AB The decision in 1965 to expand the U.S. Army's active force without a reserve mobilization quickly generated massive organizational turbulence. In this environment one unwilling soldier found an extraordinary opportunity to slip away.
C1 US Army Ctr Mil Hist, Washington, DC 20374 USA.
RP Donnelly, WM (reprint author), US Army Ctr Mil Hist, Washington, DC 20374 USA.
NR 22
TC 0
Z9 0
U1 0
U2 0
PU SOC MILITARY HISTORY
PI LEXINGTON
PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA
24450-1600 USA
SN 0899-3718
EI 1543-7795
J9 J MILITARY HIST
JI J. Mil. Hist.
PD APR
PY 2015
VL 79
IS 2
BP 457
EP 466
PG 10
WC History
SC History
GA CF9YA
UT WOS:000352922600007
ER
PT J
AU Connelly, DB
AF Connelly, Donald B.
TI Snow & Steel: The Battle of the Bulge, 1944-45
SO JOURNAL OF MILITARY HISTORY
LA English
DT Book Review
C1 [Connelly, Donald B.] US Army Command & Gen Staff Coll, Ft Leavenworth, KS 66027 USA.
RP Connelly, DB (reprint author), US Army Command & Gen Staff Coll, Ft Leavenworth, KS 66027 USA.
NR 1
TC 0
Z9 0
U1 0
U2 0
PU SOC MILITARY HISTORY
PI LEXINGTON
PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA
24450-1600 USA
SN 0899-3718
EI 1543-7795
J9 J MILITARY HIST
JI J. Mil. Hist.
PD APR
PY 2015
VL 79
IS 2
BP 531
EP 532
PG 2
WC History
SC History
GA CF9YA
UT WOS:000352922600049
ER
PT J
AU Cheppudira, B
Trevino, A
Petz, L
Gibbons, R
Clifford, J
AF Cheppudira, B.
Trevino, A.
Petz, L.
Gibbons, R.
Clifford, J.
TI Anti-nerve growth factor antibody alters morphine tolerance in rats with
and without thermal injury
SO JOURNAL OF PAIN
LA English
DT Meeting Abstract
C1 [Cheppudira, B.; Trevino, A.; Petz, L.; Gibbons, R.; Clifford, J.] US Army Inst Surg Res, San Antonio, TX USA.
NR 0
TC 0
Z9 0
U1 1
U2 2
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 1526-5900
J9 J PAIN
JI J. Pain
PD APR
PY 2015
VL 16
IS 4
SU 1
MA 333
BP S59
EP S59
PG 1
WC Clinical Neurology; Neurosciences
SC Neurosciences & Neurology
GA CF7PK
UT WOS:000352748600235
ER
PT J
AU Clifford, J
Mares, A
Hansen, J
Averitt, D
AF Clifford, J.
Mares, A.
Hansen, J.
Averitt, D.
TI Preemptive local bupivacaine attenuates mechanical and cold allodynia in
a rat model of neuropathic pain
SO JOURNAL OF PAIN
LA English
DT Meeting Abstract
C1 [Clifford, J.; Mares, A.; Hansen, J.; Averitt, D.] US Army Inst Surg Res, Ft Sam Houston, TX USA.
NR 0
TC 0
Z9 0
U1 1
U2 2
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 1526-5900
J9 J PAIN
JI J. Pain
PD APR
PY 2015
VL 16
IS 4
SU 1
MA 327
BP S57
EP S57
PG 1
WC Clinical Neurology; Neurosciences
SC Neurosciences & Neurology
GA CF7PK
UT WOS:000352748600229
ER
PT J
AU Clifford, J
Salas, M
McIntyre, M
Wong, D
AF Clifford, J.
Salas, M.
McIntyre, M.
Wong, D.
TI Tetrodotoxin attenuates thermal hyperalgesia in a rat full thickness
thermal injury pain model
SO JOURNAL OF PAIN
LA English
DT Meeting Abstract
C1 [Clifford, J.; Salas, M.; McIntyre, M.; Wong, D.] US Army Inst Surg Res, San Antonio, TX USA.
NR 0
TC 0
Z9 0
U1 2
U2 5
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 1526-5900
J9 J PAIN
JI J. Pain
PD APR
PY 2015
VL 16
IS 4
SU 1
MA 276
BP S45
EP S45
PG 1
WC Clinical Neurology; Neurosciences
SC Neurosciences & Neurology
GA CF7PK
UT WOS:000352748600178
ER
PT J
AU Nyland, J
McLean, S
Averitt, D
AF Nyland, J.
McLean, S.
Averitt, D.
TI Combined serotonin and norepinephrine reuptake inhibition reduces the
effects of stress on post-injury pain behaviors in a rat model of burn
injury
SO JOURNAL OF PAIN
LA English
DT Meeting Abstract
C1 [Nyland, J.; McLean, S.; Averitt, D.] US Army Inst Surg Res, San Antonio, TX USA.
RI Nyland, Jennifer/J-8329-2015
OI Nyland, Jennifer/0000-0002-4549-3617
NR 0
TC 0
Z9 0
U1 0
U2 1
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 1526-5900
J9 J PAIN
JI J. Pain
PD APR
PY 2015
VL 16
IS 4
SU 1
MA 362
BP S66
EP S66
PG 1
WC Clinical Neurology; Neurosciences
SC Neurosciences & Neurology
GA CF7PK
UT WOS:000352748600264
ER
PT J
AU Nyland, J
Escolas, S
Rauschendorfer, C
Aden, J
Young, A
Chung, K
AF Nyland, J.
Escolas, S.
Rauschendorfer, C.
Aden, J.
Young, A.
Chung, K.
TI Preparing for disaster: analgesic needs for mass burn casualties
SO JOURNAL OF PAIN
LA English
DT Meeting Abstract
C1 [Nyland, J.; Escolas, S.; Rauschendorfer, C.; Aden, J.; Young, A.; Chung, K.] US Army Inst Surg Res, San Antonio, TX USA.
RI Nyland, Jennifer/J-8329-2015
OI Nyland, Jennifer/0000-0002-4549-3617
NR 0
TC 0
Z9 0
U1 0
U2 1
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 1526-5900
J9 J PAIN
JI J. Pain
PD APR
PY 2015
VL 16
IS 4
SU 1
MA 191
BP S23
EP S23
PG 1
WC Clinical Neurology; Neurosciences
SC Neurosciences & Neurology
GA CF7PK
UT WOS:000352748600093
ER
PT J
AU David, IN
Thompson, T
Wolfenstine, J
Allen, JL
Sakamoto, J
AF David, Isabel N.
Thompson, Travis
Wolfenstine, Jeff
Allen, Jan L.
Sakamoto, Jeff
TI Microstructure and Li-Ion Conductivity of Hot- Pressed Cubic
Li7La3Zr2O12
SO JOURNAL OF THE AMERICAN CERAMIC SOCIETY
LA English
DT Article
ID SODIUM BETA-ALUMINA; SOLID ELECTROLYTES; GRAIN-BOUNDARY; ENERGY-STORAGE;
LITHIUM; STABILITY; CERAMICS; BATTERY; AL; TEMPERATURE
AB The effect of hot-pressing temperature on the microstructure and Li-ion transport of Al-doped, cubic Li7La3Zr2O12 (LLZO) was investigated. At fixed pressure (62MPa), the relative density was 86%, 97%, and 99% when hot-pressing at 900 degrees C, 1000 degrees C, and 1100 degrees C, respectively. Electrochemical impedance spectroscopy showed that the percent grain-boundary resistance decreased with increasing hot-pressing temperature. Hot pressing at 1100 degrees C resulted in a total conductivity of 0.37mS/cm at room temperature where the grain boundaries contributed to 8% of the total resistance; one of the lowest grain-boundary resistances reported. We believe hot pressing is an appealing technique to minimize grain-boundary resistance and enable correlations between LLZO composition and bulk ionic conductivity.
C1 [David, Isabel N.; Thompson, Travis; Sakamoto, Jeff] Michigan State Univ, Dept Chem Engn & Mat Sci, E Lansing, MI 48824 USA.
[Wolfenstine, Jeff; Allen, Jan L.] Army Res Lab, RDRL SED C, Adelphi, MD 20783 USA.
RP Sakamoto, J (reprint author), Michigan State Univ, Dept Chem Engn & Mat Sci, E Lansing, MI 48824 USA.
EM jsakamot@egr.msu.edu
FU Tank and Automotive Research and Development Engineering Center in
Warren, MI; U.S. Army Research Office [W911NF-13-1-0475]; U.S. Army
Research Laboratory (ARL)
FX ID, TT, and JS would like to acknowledge the support from the Tank and
Automotive Research and Development Engineering Center in Warren, MI and
the U.S. Army Research Office, grant W911NF-13-1-0475. JW and JLA would
like to acknowledge support of the U.S. Army Research Laboratory (ARL).
NR 38
TC 11
Z9 11
U1 21
U2 85
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0002-7820
EI 1551-2916
J9 J AM CERAM SOC
JI J. Am. Ceram. Soc.
PD APR
PY 2015
VL 98
IS 4
BP 1209
EP 1214
DI 10.1111/jace.13455
PG 6
WC Materials Science, Ceramics
SC Materials Science
GA CF5ZD
UT WOS:000352635100028
ER
PT J
AU Duarte, FJ
Taylor, TS
AF Duarte, F. J.
Taylor, Travis S.
TI Quantum entanglement physics secures space-to-space interferometric
communications
SO LASER FOCUS WORLD
LA English
DT Article
ID INTERFERENCE
AB Interferometric optical communications can potentially lead to robust, secure, and naturally encrypted long-distance laser communications in space by taking advantage of the underlying physics of quantum entanglement.
C1 [Duarte, F. J.] Interferometr Opt, Rochester, NY 14604 USA.
[Duarte, F. J.] Univ New Mexico, ECE, Albuquerque, NM 87131 USA.
[Taylor, Travis S.] US Army Space & Missile Def Command, Huntsville, AL USA.
RP Duarte, FJ (reprint author), Interferometr Opt, Rochester, NY 14604 USA.
EM opticsjournal@gmail.com
NR 22
TC 2
Z9 2
U1 3
U2 5
PU PENNWELL PUBL CO
PI NASHUA
PA 98 SPIT BROOK RD, NASHUA, NH 03062-2801 USA
SN 1043-8092
J9 LASER FOCUS WORLD
JI Laser Focus World
PD APR
PY 2015
VL 51
IS 4
BP 54
EP 58
PG 5
WC Optics
SC Optics
GA CG2IZ
UT WOS:000353099400016
ER
PT J
AU Nang, RN
Monahan, F
Diehl, GB
French, D
AF Nang, Roberto N.
Monahan, Felicia
Diehl, Glendon B.
French, Daniel
TI A Qualitative Content Analysis of Global Health Engagements in
Peacekeeping and Stability Operations Institute's Stability Operations
Lessons Learned and Information Management System
SO MILITARY MEDICINE
LA English
DT Article
AB Many institutions collect reports in databases to make important lessons-learned available to their members. The Uniformed Services University of the Health Sciences collaborated with the Peacekeeping and Stability Operations Institute to conduct a descriptive and qualitative analysis of global health engagements (GHEs) contained in the Stability Operations Lessons Learned and Information Management System (SOLLIMS). This study used a summative qualitative content analysis approach involving six steps: (1) a comprehensive search; (2) two-stage reading and screening process to identify first-hand, health-related records; (3) qualitative and quantitative data analysis using MAXQDA, a software program; (4) a word cloud to illustrate word frequencies and interrelationships; (5) coding of individual themes and validation of the coding scheme; and (6) identification of relationships in the data and overarching lessons-learned. The individual codes with the most number of text segments coded included: planning, personnel, interorganizational coordination, communication/information sharing, and resources/supplies. When compared to the Department of Defense's (DoD's) evolving GHE principles and capabilities, the SOLLIMS coding scheme appeared to align well with the list of GHE capabilities developed by the Department of Defense Global Health Working Group. The results of this study will inform practitioners of global health and encourage additional qualitative analysis of other lessons-learned databases.
C1 [Nang, Roberto N.] Uniformed Serv Univ Hlth Sci, Dept Preventat Med & Biometr, Bethesda, MD 20814 USA.
[Monahan, Felicia; Diehl, Glendon B.] Uniformed Serv Univ Hlth Sci, Ctr Disaster & Humanitarian Assistance Med, Rockville, MD 20852 USA.
[French, Daniel] US Army War Coll, US Army Peacekeeping & Stabil Operat Inst, Carlisle, PA 17013 USA.
RP Nang, RN (reprint author), Uniformed Serv Univ Hlth Sci, Dept Preventat Med & Biometr, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA.
FU Office of the Assistant Secretary of Defense for Health Affairs
FX We gratefully acknowledge the help and assistance of Dr. Gerald Quinnan
(USUHS); David Mosinski (PKSOI); Emily LaMarsh and Drs. Solomon Major,
Charles Beadling, Edwin Burkett (USUHS) and the Department of Defense
Global Health Working Group for their permission to use their list of
Global Health Engagement Capabilities. This research project was funded
by the M.O.D.E.L. Grant from the Office of the Assistant Secretary of
Defense for Health Affairs.
NR 16
TC 1
Z9 1
U1 1
U2 7
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
EI 1930-613X
J9 MIL MED
JI Milit. Med.
PD APR
PY 2015
VL 180
IS 4
BP 409
EP 418
DI 10.7205/MILMED-D-14-00387
PG 10
WC Medicine, General & Internal
SC General & Internal Medicine
GA CF6UJ
UT WOS:000352691600008
PM 25826346
ER
PT J
AU Niles, SE
Balazs, GC
Cawley, C
Bosse, M
Mackenzie, E
Li, YZ
Andersen, RC
AF Niles, Sarah E.
Balazs, George C.
Cawley, Christina
Bosse, Michael
Mackenzie, Ellen
Li, Yaunzhang
Andersen, Romney C.
TI Translating Research Into Practice: Is Evidence-Based Medicine Being
Practiced in Military-Relevant Orthopedic Trauma?
SO MILITARY MEDICINE
LA English
DT Article
ID OPERATION ENDURING FREEDOM; TIBIA FRACTURES; FEMORAL-NECK; AMPUTATION;
INJURIES; DIAGNOSIS; OUTCOMES; WOUNDS
AB Orthopedic trauma remains one of the most survivable battlefield injuries seen in modern conflicts. Translating research into practice is a critical bridge that permits surgeons to further optimize medical outcomes. Orthopedic surgeons serving in the military may treat little to no trauma in their stateside practice. In conflict zones, however, the majority of their patients will have traumatic injuries. Determining risk factors for nonevidence-based practice can help identify provider knowledge gaps, which can then be targeted before deployment. Surveys were developed which sought to identify factors contributing to continued medical education and practice, as well as scenario-based questions on military-relevant orthopedic trauma. Analysis of 188 survey respondents revealed that providers with military service and less than 10 years of practice are optimally bridging research into military-relevant orthopedic trauma practice.
C1 [Niles, Sarah E.; Balazs, George C.; Andersen, Romney C.] Walter Reed Natl Mil Med Ctr, Dept Orthoped, Bethesda, MD 20889 USA.
[Balazs, George C.; Andersen, Romney C.] Uniformed Serv Univ Hlth Sci, F Edward Hebert Sch Med, Bethesda, MD 20814 USA.
[Cawley, Christina] Lebanon Vet Affairs Med Ctr, Lebanon, PA 17042 USA.
[Bosse, Michael] Carolinas Med Ctr, Dept Orthoped Surg, Charlotte, NC 28262 USA.
[Mackenzie, Ellen] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Hlth Policy & Management, Baltimore, MD 21205 USA.
[Li, Yaunzhang] Walter Reed Army Inst Res, Silver Spring, MD 20910 USA.
RP Niles, SE (reprint author), Walter Reed Natl Mil Med Ctr, Dept Orthoped, 8901 Wisconsin Ave, Bethesda, MD 20889 USA.
RI Balazs, George/I-3202-2016
OI Balazs, George/0000-0003-2822-2986
FU Geneva Foundation [W81XWH-08-2-0085]
FX This study was funded by the Geneva Foundation (grant no.
W81XWH-08-2-0085).
NR 14
TC 0
Z9 0
U1 1
U2 1
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
EI 1930-613X
J9 MIL MED
JI Milit. Med.
PD APR
PY 2015
VL 180
IS 4
BP 445
EP 453
DI 10.7205/MILMED-D-14-00296
PG 9
WC Medicine, General & Internal
SC General & Internal Medicine
GA CF6UJ
UT WOS:000352691600012
PM 25826350
ER
PT J
AU Mysliwiec, V
Capaldi, VF
Gill, J
Baxter, T
O'Reilly, BM
Matsangas, P
Roth, BJ
AF Mysliwiec, Vincent
Capaldi, Vincent F., II
Gill, Jessica
Baxter, Tristin
O'Reilly, Brian M.
Matsangas, Panagiotis
Roth, Bernard J.
TI Adherence to Positive Airway Pressure Therapy in US Military Personnel
With Sleep Apnea Improves Sleepiness, Sleep Quality, and Depressive
Symptoms
SO MILITARY MEDICINE
LA English
DT Article
ID POSTTRAUMATIC-STRESS-DISORDER; MOTOR-VEHICLE COLLISIONS; TRAUMATIC
BRAIN-INJURY; CPAP ADHERENCE; NASAL CPAP; DAYTIME SLEEPINESS;
CONTROLLED-TRIAL; OF-LIFE; ADULTS; AFGHANISTAN
AB Objectives: Obstructive sleep apnea (OSA) is frequently diagnosed in U.S. military personnel. OSA is associated with sleepiness, poor sleep quality, and service-related illnesses of insomnia, depression, post-traumatic stress disorder, and traumatic brain injury. Methods: Observational study of active duty military personnel with OSA and adherence to positive airway pressure (PAP) assessed with smart chip technology. Results: 58 men with mean age 36.2 +/- 7.7 years, mean body mass index 31.4 +/- 3.7 with mean apnea-hypopnea index (AHI) 19.1 +/- 19.0 are reported. 23 (39.7%) participants were adherent to PAP, and 35 (60.3%) were nonadherent. No significant differences in baseline demographics, apnea-hypopnea index, service-related illnesses, or clinical instrument scores. Military personnel adherent to PAP had significantly improved sleepiness (p = 0.007), sleep quality (p = 0.013), depressive symptoms (p = 0.01), energy/fatigue (p = 0.027), and emotional well-being (p = 0.024). Participants with moderate-severe OSA were more likely to be in the adherent group when compared with participants diagnosed with mild OSA. Conclusions: Military personnel with OSA have low adherence to PAP. Adherence is associated with improved depressive symptoms, sleepiness, sleep quality, energy/fatigue, emotional well-being, and social functioning. Future research should focus on interventions to improve the management of OSA in military personnel.
C1 [Mysliwiec, Vincent; Baxter, Tristin; O'Reilly, Brian M.; Roth, Bernard J.] Madigan Army Med Ctr, Dept Pulm Sleep Med Crit Care, Tacoma, WA 98431 USA.
[Capaldi, Vincent F., II] Walter Reed Army Inst Res, Silver Spring, MD 20910 USA.
[Gill, Jessica] NIH, Bethesda, MD 20892 USA.
[Matsangas, Panagiotis] US Navy, Postgrad Sch, Dept Operat Res, Monterey, CA 93943 USA.
RP Mysliwiec, V (reprint author), Madigan Army Med Ctr, Dept Pulm Sleep Med Crit Care, 9040A Fitzsimmons Ave, Tacoma, WA 98431 USA.
FU Center for Neuroscience and Regenerative Medicine [60855]
FX The authors thank Angela Mysliwiec, MD, Madigan Army Medical Center, for
editing assistance and review of the manuscript. Dr. Angela Mysliwiec
did not receive compensation for her contributions. This study was
supported, in part, by grant no. 60855 from the Center for Neuroscience
and Regenerative Medicine.
NR 55
TC 2
Z9 2
U1 0
U2 6
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
EI 1930-613X
J9 MIL MED
JI Milit. Med.
PD APR
PY 2015
VL 180
IS 4
BP 475
EP 482
DI 10.7205/MILMED-D-14-00197
PG 8
WC Medicine, General & Internal
SC General & Internal Medicine
GA CF6UJ
UT WOS:000352691600016
PM 25826354
ER
PT J
AU Schierkolk, A
AF Schierkolk, Andrea
TI This Dust Was Once the Man: Commemorating the 150th Anniversary of
Lincoln's Last Hours
SO MILITARY MEDICINE
LA English
DT Editorial Material
C1 US Army, Med Res & Mat Command, Natl Museum Hlth & Med, Silver Spring, MD 20910 USA.
RP Schierkolk, A (reprint author), US Army, Med Res & Mat Command, Natl Museum Hlth & Med, 2500 Linden Lane, Silver Spring, MD 20910 USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
EI 1930-613X
J9 MIL MED
JI Milit. Med.
PD APR
PY 2015
VL 180
IS 4
BP 483
EP 484
DI 10.7205/MILMED-D-14-00637
PG 2
WC Medicine, General & Internal
SC General & Internal Medicine
GA CF6UJ
UT WOS:000352691600017
PM 25826355
ER
PT J
AU DeLacy, BG
Miller, OD
Hsu, CW
Zander, Z
Lacey, S
Yagloski, R
Fountain, AW
Valdes, E
Anquillare, E
Soljacic, M
Johnson, SG
Joannopoulos, JD
AF DeLacy, Brendan G.
Miller, Owen D.
Hsu, Chia Wei
Zander, Zachary
Lacey, Steven
Yagloski, Raymond
Fountain, Augustus W.
Valdes, Erica
Anquillare, Emma
Soljacic, Mann
Johnson, Steven G.
Joannopoulos, John D.
TI Coherent Plasmon-Exciton Coupling in Silver Platelet-J-aggregate
Nanocomposites
SO NANO LETTERS
LA English
DT Article
DE Plexcitons; plasmons; excitons; J-aggregates
ID FANO RESONANCES; COMPOSITE NANOPARTICLES; INDUCED TRANSPARENCY;
ABSORPTION; SYSTEMS; ENHANCEMENT; NANOPRISMS; DYNAMICS; SPECTRA; AU
AB Hybrid nanostructures that couple plasmon and exciton resonances generate hybridized energy states, called plexcitons, which may result in unusual light-matter interactions. We report the formation of a transparency dip in the visible spectra of colloidal suspensions containing silver nanoplatelets and a cyanine dye, 1,1'-diethyl-2,2'-cyanine iodide (PIC). PIC was electrostatically adsorbed onto the surface of silver nanoplatelet core particles, forming an outer J-aggregate shell. This core-shell architecture provided a framework for coupling the plasmon resonance of the silver nanoplatelet core with the exciton resonance of the J-aggregate shell. The sizes and aspect ratios of the silver nanoplatelets were controlled to ensure the overlap of the plasmon and exciton resonances. As a measure of the plasmon-exciton coupling strength in the system, the experimentally observed transparency dips correspond to a Rabi splitting energy of 207 meV, among the highest reported for colloidal nanoparticles. The optical properties of the silver platelet-J-aggregate nanocomposites were supported numerically and analytically by the boundary-element method and temporal coupled-mode theory, respectively. Our theoretical predictions and experimental results confirm the presence of a transparency dip for the silver nanoplatelet core J-aggregate shell structures. Additionally, the numerical and analytical calculations indicate that the observed transparencies are dominated by the coupling of absorptive resonances, as opposed to the coupling of scattering resonances. Hence, we describe the suppressed extinction in this study as an induced transparency rather than a Fano resonance.
C1 [DeLacy, Brendan G.; Zander, Zachary; Lacey, Steven; Yagloski, Raymond; Fountain, Augustus W.; Valdes, Erica] US Army Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA.
[Miller, Owen D.; Johnson, Steven G.] MIT, Dept Math, Cambridge, MA 02139 USA.
[Hsu, Chia Wei; Anquillare, Emma; Soljacic, Mann; Joannopoulos, John D.] MIT, Dept Phys, Cambridge, MA 02139 USA.
[Hsu, Chia Wei] Harvard Univ, Dept Phys, Cambridge, MA 02138 USA.
RP DeLacy, BG (reprint author), US Army Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA.
EM brendan.g.delacy.civ@mail.mil
RI Hsu, Chia Wei/G-5486-2011
OI Hsu, Chia Wei/0000-0002-9609-7155
FU Department of the Army Basic Research Program; Edgewood Chemical
Biological Center; U.S. Army Research Office through the Institute for
Soldier Nanotechnologies [W911NF-13-D-0001]
FX This research was funded by the Department of the Army Basic Research
Program and sponsored by the Edgewood Chemical Biological Center.
Support was also provided by the U.S. Army Research Office through the
Institute for Soldier Nanotechnologies under Contract No.
W911NF-13-D-0001.
NR 41
TC 22
Z9 22
U1 14
U2 80
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 1530-6984
EI 1530-6992
J9 NANO LETT
JI Nano Lett.
PD APR
PY 2015
VL 15
IS 4
BP 2588
EP 2593
DI 10.1021/acs.nanolett.5b00157
PG 6
WC Chemistry, Multidisciplinary; Chemistry, Physical; Nanoscience &
Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied;
Physics, Condensed Matter
SC Chemistry; Science & Technology - Other Topics; Materials Science;
Physics
GA CF7QA
UT WOS:000352750200056
PM 25723653
ER
PT J
AU Sweeney, LM
Sommerville, DR
Channel, SR
Sharits, BC
Gargas, NM
Gut, CP
AF Sweeney, Lisa M.
Sommerville, Douglas R.
Channel, Stephen R.
Sharits, Brian C.
Gargas, Nathan M.
Gut, Chester P., Jr.
TI Evaluating the validity and applicable domain of the toxic load model:
Impact of concentration vs. time profile on inhalation lethality of
hydrogen cyanide
SO REGULATORY TOXICOLOGY AND PHARMACOLOGY
LA English
DT Article
DE Hydrogen cyanide; Nose-only inhalation; Acute lethality; Non-constant
concentrations; Pulsed exposures; Toxic load model
ID EXPOSURE; RATS; KINETICS
AB The ten Berge model (or "toxic load" model) is often used to estimate the acute toxicity for varying combinations of inhaled concentration and duration. Expressed as C-n x t = toxic load (TL), TLs are assumed constant for various combinations of concentration (C) and time (t). Experimental data in a recent acute inhalation study of rats exposed to time-varying concentrations of hydrogen cyanide (HCN) supported the validity of the toxic load model except under very brief, discontinuous, high concentration exposures. In the present investigation, experiments were conducted to extend the evaluation of the applicable domain of the model for acute lethality of HCN in the rat (cumulative exposure range of 2900 11,000 ppm min). The lethality of HCN over very short (<5 min) durations of high concentrations did not conform to the toxic load model. A value of n = 1.57 was determined for uninterrupted exposures min. For 30-min exposures, the presence or absence of a gap between two exposure pulses of different concentrations, the relative duration, relative height, and the ordering of the pulses (low then high, vs. high then low) did not appear to have a meaningful impact on the toxic load required for median lethality. (C) 2015 Elsevier Inc. All rights reserved.
C1 [Sweeney, Lisa M.] Henry M Jackson Fdn Adv Mil Med, Naval Med Res Unit Dayton, Wright Patterson AFB, OH 45433 USA.
[Sommerville, Douglas R.] US Army, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA.
[Channel, Stephen R.] Leidos, Linton, IN 47441 USA.
[Sharits, Brian C.; Gargas, Nathan M.; Gut, Chester P., Jr.] CAMRIS, Naval Med Res Unit Dayton, Wright Patterson AFB, OH 45433 USA.
RP Sweeney, LM (reprint author), Henry M Jackson Fdn Adv Mil Med, Naval Med Res Unit Dayton, Wright Patterson AFB, OH 45433 USA.
EM lisa.sweeney.3.ctr@us.af.mil
FU Defense Threat Reduction Agency [H1107]
FX This work was supported by the Defense Threat Reduction Agency. Dr.
Sweeney, Mr. Sharits, Mr. Gargas and Mr. Gut's efforts were conducted
under Work Unit Number H1107.
NR 26
TC 3
Z9 3
U1 2
U2 13
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0273-2300
EI 1096-0295
J9 REGUL TOXICOL PHARM
JI Regul. Toxicol. Pharmacol.
PD APR
PY 2015
VL 71
IS 3
BP 571
EP 584
DI 10.1016/j.yrtph.2015.02.015
PG 14
WC Medicine, Legal; Pharmacology & Pharmacy; Toxicology
SC Legal Medicine; Pharmacology & Pharmacy; Toxicology
GA CF8PG
UT WOS:000352823800023
PM 25720732
ER
PT J
AU Gordon, WO
Peterson, GW
Durke, EM
AF Gordon, Wesley O.
Peterson, Gregory W.
Durke, Erin M.
TI Reduced Chemical Warfare Agent Sorption in Polyurethane-Painted Surfaces
via Plasma-Enhanced Chemical Vapor Deposition of Perfluoroalkanes
SO ACS APPLIED MATERIALS & INTERFACES
LA English
DT Article
DE chemical warfare agent resistance; plasma treatment; paint; polyurethane
ID COATINGS; FILMS
AB Perfluoralkalation via plasma chemical vapor deposition has been used to improve hydrophobicity of surfaces. We have investigated this technique to improve the resistance of commercial polyurethane coatings to chemicals, such as chemical warfare agents. The reported results indicate the surface treatment minimizes the spread of agent droplets and the sorption of agent into the coating. The improvement in resistance is likely due to reduction of the coating's surface free energy via fluorine incorporation, but may also have contributing effects from surface morphology changes. The data indicates that plasma-based surface modifications may have utility in improving chemical resistance of commercial coatings.
C1 [Gordon, Wesley O.; Peterson, Gregory W.] US Army Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA.
[Durke, Erin M.] Excet Inc, Springfield, VA 22151 USA.
RP Gordon, WO (reprint author), US Army Edgewood Chem Biol Ctr, 5183 Blackhawk Rd, Aberdeen Proving Ground, MD 21010 USA.
EM wesley.o.gordon.civ@mail.mil
FU Joint Science and Technology Office for Chemical Biological Defense
FX This work was supported by the Joint Science and Technology Office for
Chemical Biological Defense. The authors also thank Prof. John Morris at
Virginia Tech for collecting the SEM data, as well as Patrick Riley,
Janlyn Eikenberg, and Stefanie Quinones of Leidos, Inc. for performing
testing at ECBC. Matthew Shue at ECBC is also acknowledged for
supporting this work.
NR 15
TC 2
Z9 2
U1 2
U2 13
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 1944-8244
J9 ACS APPL MATER INTER
JI ACS Appl. Mater. Interfaces
PD APR 1
PY 2015
VL 7
IS 12
BP 6402
EP 6405
DI 10.1021/acsami.5b00790
PG 4
WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary
SC Science & Technology - Other Topics; Materials Science
GA CF0PM
UT WOS:000352246700006
PM 25775244
ER
PT J
AU Seehusen, DA
Grogan, SP
AF Seehusen, Dean A.
Grogan, Scott P.
TI Magnesium Sulfate for Prevention of Preterit Birth
SO AMERICAN FAMILY PHYSICIAN
LA English
DT Editorial Material
C1 [Seehusen, Dean A.; Grogan, Scott P.] Dwight D Eisenhower Army Med Ctr, Ft Gordon, GA 30905 USA.
RP Seehusen, DA (reprint author), Dwight D Eisenhower Army Med Ctr, Ft Gordon, GA 30905 USA.
NR 5
TC 0
Z9 0
U1 0
U2 0
PU AMER ACAD FAMILY PHYSICIANS
PI KANSAS CITY
PA 8880 WARD PARKWAY, KANSAS CITY, MO 64114-2797 USA
SN 0002-838X
EI 1532-0650
J9 AM FAM PHYSICIAN
JI Am. Fam. Physician
PD APR 1
PY 2015
VL 91
IS 7
BP 444
EP 445
PG 2
WC Primary Health Care; Medicine, General & Internal
SC General & Internal Medicine
GA CE8UM
UT WOS:000352119600006
PM 25884743
ER
PT J
AU Perkins, ZB
Yet, B
Glasgow, S
Cole, E
Marsh, W
Brohi, K
Rasmussen, TE
Tai, NRM
AF Perkins, Z. B.
Yet, B.
Glasgow, S.
Cole, E.
Marsh, W.
Brohi, K.
Rasmussen, T. E.
Tai, N. R. M.
TI Meta-analysis of prognostic factors for amputation following surgical
repair of lower extremity vascular trauma
SO BRITISH JOURNAL OF SURGERY
LA English
DT Review
ID POPLITEAL ARTERY TRAUMA; DAMAGE CONTROL RESUSCITATION; OPEN TIBIAL
FRACTURES; LIMB SALVAGE; MANGLED EXTREMITY; KNEE DISLOCATION;
NATIONAL-TRAUMA; MAJOR TRAUMA; DATA-BANK; SYSTEMATIC REVIEWS
AB Background: Lower extremity vascular trauma (LEVT) is a major cause of amputation. A clear understanding of prognostic factors for amputation is important to inform surgical decision-making, patient counselling and risk stratification. The aim was to develop an understanding of prognostic factors for amputation following surgical repair of LEVT.
Methods: A systematic review was conducted to identify potential prognostic factors. Bayesian meta-analysis was used to calculate an absolute (pooled proportion) and relative (pooled odds ratio, OR) measure of the amputation risk for each factor.
Results: Forty-five studies, totalling 3187 discrete LEVT repairs, were included. The overall amputation rate was 10.0 (95 per cent credible interval 7.4 to 13.1) per cent. Significant prognostic factors for secondary amputation included: associated major soft tissue injury (26 versus 8 per cent for no soft tissue injury; OR 5.80), compartment syndrome (28 versus 6 per cent; OR 5.11), multiple arterial injuries (18 versus 9 per cent; OR4.85), duration of ischaemia exceeding 6 h (24 versus 5 per cent; OR4.40), associated fracture (14 versus 2 per cent; OR 4.30), mechanism of injury (blast 19 per cent, blunt 16 per cent, penetrating 5 per cent), anatomical site of injury (iliac 18 per cent, popliteal 14 per cent, tibial 10 per cent, femoral 4 per cent), age over 55 years (16 versus 9 per cent; OR 3.03) and sex (men 7 per cent versus women 8 per cent; OR 0.64). Shock and nerve or venous injuries were not significant prognostic factors for secondary amputation.
Conclusion: A significant proportion of patients who undergo lower extremity vascular trauma repair will require secondary amputation. This meta-analysis describes significant prognostic factors needed to inform surgical judgement, risk assessment and patient counselling.
C1 [Perkins, Z. B.; Glasgow, S.; Cole, E.; Brohi, K.; Tai, N. R. M.] Univ London, Ctr Trauma Sci, London, England.
[Yet, B.; Marsh, W.] Univ London, Dept Comp Sci, London, England.
[Tai, N. R. M.] Royal Ctr Def Med, Acad Dept Mil Surg & Trauma, Birmingham, W Midlands, England.
[Rasmussen, T. E.] US Army Med Res & Mat Command, Ft Detrick, MD USA.
RP Perkins, ZB (reprint author), Royal London Hosp, Ctr Trauma Sci, London E1 1BB, England.
EM zane.perkins@nhs.net
RI Marsh, David/A-3213-2016;
OI Marsh, David/0000-0003-0212-6363; Perkins, Zane/0000-0003-4807-8803;
Yet, Barbaros/0000-0003-4058-2677
NR 93
TC 2
Z9 2
U1 2
U2 8
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0007-1323
EI 1365-2168
J9 BRIT J SURG
JI Br. J. Surg.
PD APR
PY 2015
VL 102
IS 5
BP 436
EP 450
DI 10.1002/bjs.9689
PG 15
WC Surgery
SC Surgery
GA CE9AE
UT WOS:000352134800002
PM 25706113
ER
PT J
AU Stanley, JK
Lotufo, GR
Biedenbach, JM
Chappell, P
Gust, KA
AF Stanley, Jacob K.
Lotufo, Guilherme R.
Biedenbach, James M.
Chappell, Pornsawan
Gust, Kurt A.
TI TOXICITY OF THE CONVENTIONAL ENERGETICS TNT AND RDX RELATIVE TO NEW
INSENSITIVE MUNITIONS CONSTITUENTS DNAN AND NTO IN RANA PIPIENS TADPOLES
SO ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY
LA English
DT Article
DE Amphibians; Munitions constituents; Aquatic toxicology; Behavioral
toxicology
ID COMPOUND; 2,4,6-TRINITROTOLUENE; 2,4-DINITROANISOLE
AB An initiative within the US military is targeting the replacement of traditional munitions constituents with insensitive munitions to reduce risk of accidental detonation. The purpose of the present study was to comparatively assess toxicity of the traditional munitions constituents 2,4,6-trinitrotoluene (TNT) and 1,3,5-trinitroperhydro-1,3,5-triazine (RDX) with the new insensitive munitions constituents 2,4-dinitroanisole (DNAN) and 3-nitro-1,2,4-triazol-5-one (NTO). The following exposure durations were performed with Rana pipiens (leopard frog) tadpoles: TNT and DNAN, 96h and 28d; RDX, 10 d and 28d; NTO, 28 d. The 96-h 50% lethal concentration (LC50) values and 95% confidence intervals for TNT and DNAN were 4.4mg/L (4.2mg/L, 4. 7mg/L) and 24.3mg/L (21.3mg/L, 27.6mg/L), respectively. No significant impacts on survival were observed in the 10-d exposure to RDX up to 25.3mg/L. Effects on tadpole swimming distance were observed with a lowest-observed-effect concentration (LOEC) of 5.9mg/L RDX. In the 28-d exposures, the LOECs for survival for TNT, DNAN, and NTO were 0.003mg/L, 2.4mg/L, and 5.0mg/L, respectively. No significant mortality was observed in the RDX chronic 28-d exposure up to the highest treatment level tested of 28.0mg/L. Neither tadpole developmental stage nor growth was significantly affected in any of the 28-d exposures. Rana pipiens were very sensitive to chronic TNT exposure, with an LOEC 3 orders of magnitude lower than those for insensitive munitions constituents DNAN and NTO. Environ Toxicol Chem 2015;34:873-879. (c) 2015 SETAC
C1 [Stanley, Jacob K.; Lotufo, Guilherme R.; Biedenbach, James M.; Gust, Kurt A.] US Army Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA.
[Chappell, Pornsawan] Badger Tech Serv, Vicksburg, MS USA.
RP Stanley, JK (reprint author), US Army Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA.
EM jacob.k.stanley@us.army.mil
FU US Army's Environmental Quality Technology Basic Research Program
FX Permission was granted by the Chief of Engineers to publish this
material. This work was supported by the US Army's Environmental Quality
Technology Basic Research Program (E. Ferguson, Technical Director). The
authors thank B. Winstead of BAE Systems for help with obtaining
insensitive munitions compounds.
NR 37
TC 2
Z9 2
U1 3
U2 34
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0730-7268
EI 1552-8618
J9 ENVIRON TOXICOL CHEM
JI Environ. Toxicol. Chem.
PD APR
PY 2015
VL 34
IS 4
BP 873
EP 879
DI 10.1002/etc.2890
PG 7
WC Environmental Sciences; Toxicology
SC Environmental Sciences & Ecology; Toxicology
GA CE8NY
UT WOS:000352101100024
PM 25586961
ER
PT J
AU Lotufo, GR
Biedenbach, JM
Sims, JG
Chappell, P
Stanley, JK
Gust, KA
AF Lotufo, Guilherme R.
Biedenbach, James M.
Sims, Jerre G.
Chappell, Pornsawan
Stanley, Jacob K.
Gust, Kurt A.
TI BIOACCUMULATION KINETICS OF THE CONVENTIONAL ENERGETICS TNT AND RDX
RELATIVE TO INSENSITIVE MUNITIONS CONSTITUENTS DNAN AND NTO IN RANA
PIPIENS TADPOLES
SO ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY
LA English
DT Article
DE Amphibians; Bioconcentration; Energetics; Toxicokinetics
ID CATFISH ICTALURUS-PUNCTATUS; FRESH-WATER AMPHIPODS; ORGANIC-CHEMICALS;
EXPLOSIVE COMPOUNDS; AQUATIC ORGANISMS; TOXICITY; 2,4,6-TRINITROTOLUENE;
TOXICOKINETICS; ACCUMULATION; 2,4-DINITROANISOLE
AB The manufacturing of explosives and their loading, assembling, and packing into munitions for use in testing on training sites or battlefields has resulted in contamination of terrestrial and aquatic sites that may pose risk to populations of sensitive species. The bioaccumulative potential of the conventional explosives 2,4,6-trinitrotoluene (TNT) and hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) and of the insensitive munitions (i.e., less shock sensitive) compound 2,4-dinitroanisole (DNAN) were assessed using the Northern leopard frog, Rana pipiens. Trinitrotoluene entering the organism was readily biotransformed to aminodinitrotoluenes, whereas no transformation products were measured for RDX or DNAN. Uptake clearance rates were relatively slow and similar among compounds (1.32-2.19L kg(-1) h(-1)). Upon transfer to uncontaminated water, elimination rate was very fast, resulting in the prediction of fast time to approach steady state (5h or less) and short elimination half-lives (1.2h or less). A preliminary bioconcentration factor of 0.25L kg(-1) was determined for the insensitive munitions compound 3-nitro-1,2,4-trizole-5-one (NTO) indicating negligible bioaccumulative potential. Because of the rapid elimination rate for explosives, tadpoles inhabiting contaminated areas are expected to experience harmful effects only if under constant exposure conditions given that body burdens can rapidly depurate preventing tissue concentrations from persisting at levels that may cause detrimental biological effects. Environ Toxicol Chem 2015;34:880-886. (c) 2014 SETAC
C1 [Lotufo, Guilherme R.; Biedenbach, James M.; Sims, Jerre G.; Stanley, Jacob K.; Gust, Kurt A.] US Army Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA.
[Chappell, Pornsawan] Badger Tech Serv, San Antonio, TX USA.
RP Lotufo, GR (reprint author), US Army Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA.
EM guilherme.lotufo@usace.army.mil
FU US Army's Environmental Quality Technology Basic Research Program
FX Permission was granted by the Chief of Engineers to publish this
material. This work was supported by the US Army's Environmental Quality
Technology Basic Research Program (E. Ferguson). The authors thank B.
Winstead of BAE Systems for help with obtaining insensitive munitions
compounds.
NR 43
TC 1
Z9 1
U1 5
U2 30
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0730-7268
EI 1552-8618
J9 ENVIRON TOXICOL CHEM
JI Environ. Toxicol. Chem.
PD APR
PY 2015
VL 34
IS 4
BP 880
EP 886
DI 10.1002/etc.2863
PG 7
WC Environmental Sciences; Toxicology
SC Environmental Sciences & Ecology; Toxicology
GA CE8NY
UT WOS:000352101100025
PM 25524181
ER
PT J
AU Yaede, JR
McBride, JH
Nelson, ST
Park, CB
Flores, JA
Turnbull, SJ
Tingey, DG
Jacobsen, RT
Dong, CD
Gardner, NL
AF Yaede, Johnathan R.
McBride, John H.
Nelson, Stephen T.
Park, Choon B.
Flores, Joshua A.
Turnbull, Stephen J.
Tingey, David G.
Jacobsen, Rae T.
Dong, Corey D.
Gardner, Nicole L.
TI A geophysical strategy for measuring the thickness of the critical zone
developed over basalt lavas
SO GEOSPHERE
LA English
DT Article
ID SHEAR-WAVE VELOCITY; SURFACE-WAVES; MULTICHANNEL ANALYSIS; WEATHERING
RATES; HAWAII; MASW; EVOLUTION; EROSION; CLIMATE; DEPTH
AB Estimates of the thickness variation in lateritic weathering profiles ( LWPs) are important in tropical areas underlain by young basalt lavas like those found in Hawaii. Seismic shear-wave velocity data were obtained by a new application of multichannel analysis of surface waves ( MASW) to map variations in the LWP and to derive the downward rate of advance of the weathering front in basaltic lavas. The MASW technique proved highly capable of imaging the internal structure and base of the critical zone, as confirmed by borehole data and direct field measurements. Profile thickness thus obtained, rapidly and without drilling, has applications to engineering and geochemical studies. The rate of advance of the weathering front derived from MASW in Oahu ranged from 0.010 m/ka to 0.026 m/ka in mesic zones (similar to 1500 mm/a rainfall), whereas an area with similar to 800 mm/a revealed rates from 0.005 m/ka to 0.011 m/ka. These rates are comparable to those derived from recent solute-based mass balance studies of ground and surface water. Conventional P-wave seismic reflection did not perform as well for detecting boundaries due to a gradational seismic velocity structure within the weathering profile. Shear-wave velocity models showed internal variations that may be caused by textural differences in parental lava flows. Limitations in imaging depth were overcome by innovative experiment designs. Increasing source-receiver offsets and merging surface-wave dispersion curves allowed for a more objective derivation of velocity-frequency relations. Further improvements were made from a recently developed form of the combined active and passive source technique. These advances allowed for more detailed and deeper imaging of the subsurface with greater confidence. Velocity models derived from MASW can thus describe the LWP in terms of depth and variability in stiffness.
C1 [Yaede, Johnathan R.; McBride, John H.; Nelson, Stephen T.; Flores, Joshua A.; Tingey, David G.; Jacobsen, Rae T.; Dong, Corey D.; Gardner, Nicole L.] Brigham Young Univ, Dept Geol Sci, Provo, UT 84602 USA.
[Park, Choon B.] Pk Seism LLC, Shelton, CT 06484 USA.
[Turnbull, Stephen J.] US Army, Waterways Expt Stn, Coastal & Hydraul Lab Engineer & Res & Dev Ctr, Vicksburg, MS 39180 USA.
RP Yaede, JR (reprint author), Brigham Young Univ, Dept Geol Sci, Provo, UT 84602 USA.
FU College of Physical and Mathematical Sciences at Brigham Young
University; Landmark (Halliburton) University Grant Program
FX This research was supported in part by funding from the College of
Physical and Mathematical Sciences at Brigham Young University. Data
processing and visualization were made possible by a generous software
grant from the Landmark (Halliburton) University Grant Program. We thank
Michael F. Weber and students from Brigham Young University-Hawaii for
their assistance in the field work.
NR 50
TC 1
Z9 1
U1 2
U2 13
PU GEOLOGICAL SOC AMER, INC
PI BOULDER
PA PO BOX 9140, BOULDER, CO 80301-9140 USA
SN 1553-040X
J9 GEOSPHERE
JI Geosphere
PD APR
PY 2015
VL 11
IS 2
BP 514
EP 532
DI 10.1130/GES01142.1
PG 19
WC Geosciences, Multidisciplinary
SC Geology
GA CF0GO
UT WOS:000352221400015
ER
PT J
AU Freese, EC
Gist, NH
Acitelli, RM
McConnell, WJ
Beck, CD
Hausman, DB
Murrow, JR
Cureton, KJ
Evans, EM
AF Freese, Eric C.
Gist, Nicholas H.
Acitelli, Rachelle M.
McConnell, Whitni J.
Beck, Catherine D.
Hausman, Dorothy B.
Murrow, Jonathan R.
Cureton, Kirk J.
Evans, Ellen M.
TI Acute and chronic effects of sprint interval exercise on postprandial
lipemia in women at-risk for the metabolic syndrome
SO JOURNAL OF APPLIED PHYSIOLOGY
LA English
DT Article
DE triglycerides; interval exercise; meal challenge; exercise training
ID LIPASE GENE-EXPRESSION; HUMAN SKELETAL-MUSCLE; HIGH-FAT MEAL; RESISTANCE
EXERCISE; MODERATE EXERCISE; INTENSITY; ENDURANCE; ADAPTATIONS; MEN;
TRIGLYCERIDE
AB Individuals diagnosed with the metabolic syndrome (MetS) exhibit elevated postprandial lipemia (PPL). The aims of this investigation were to determine 1) if an acute bout of sprint interval training (SIT) attenuates PPL; and 2) if the attenuation of PPL following 6 wk of SIT is magnified compared with a single session of SIT prior to training in women at-risk for MetS (n = 45; 30-65 yr). Women were randomized to SIT (n = 22) or a nonexercise control (n = 23; CON) for 6 wk. Postprandial responses to a high-fat meal challenge (HFMC) were assessed in the CON group before (B-HFMC) and after (Post-HFMC) without prior exercise and in the SIT group at baseline (B-HFMC) without prior exercise, after an acute bout of SIT (four 30-s all-out sprints with 4-min recovery) prior to (Pre-HFMC), and after the 6-wk intervention (Post-HFMC). Responses to the HFMC were assessed by collecting venous blood samples in the fasted state and at 0, 30, 60, 120, and 180 min postprandial. Compared with baseline, an acute bout of SIT before (Pre-HFMC) and after the 6-wk intervention (PostHFMC) significantly attenuated fasted TG (P < 0.05; 16.6% and 12.3%, respectively) and postprandial area under the curve (13.1% and 9.7%, respectively; tAUC) TG responses. There was no difference in fasted or tAUC TG responses between Pre-HFMC and Post-HFMC. SIT is an effective mode of exercise to reduce fasted and postprandial TG concentrations in women at-risk for MetS. Six weeks of SIT does not magnify the attenuation of PPL in response to a single session of SIT.
C1 [Freese, Eric C.; Gist, Nicholas H.; Acitelli, Rachelle M.; McConnell, Whitni J.; Beck, Catherine D.; Cureton, Kirk J.; Evans, Ellen M.] Univ Georgia, Dept Kinesiol, Athens, GA 30602 USA.
[Gist, Nicholas H.] US Mil Acad, Dept Phys Educ, West Point, NY 10996 USA.
[Hausman, Dorothy B.] Univ Georgia, Dept Foods & Nutr, Athens, GA 30602 USA.
[Murrow, Jonathan R.] Univ Georgia Med Partnership, Georgia Regents Univ, Athens, GA USA.
RP Freese, EC (reprint author), Univ Georgia, Ramsey Ctr, Dept Kinesiol, 330 River Rd, Athens, GA 30602 USA.
EM efreese2@gmail.com
FU Egg Nutrition Center
FX This trial was funded by the Egg Nutrition Center.
NR 43
TC 3
Z9 3
U1 0
U2 7
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 8750-7587
EI 1522-1601
J9 J APPL PHYSIOL
JI J. Appl. Physiol.
PD APR 1
PY 2015
VL 118
IS 7
BP 872
EP 879
DI 10.1152/japplphysiol.00380.2014
PG 8
WC Physiology; Sport Sciences
SC Physiology; Sport Sciences
GA CE9CM
UT WOS:000352141200011
PM 25593284
ER
PT J
AU Feldman, J
Hanrahan, BM
Misra, S
Fan, XZ
Waits, CM
Mitcheson, PD
Ghodssi, R
AF Feldman, Jeremy
Hanrahan, Brendan Michael
Misra, Saswat
Fan, Xiao Zhu
Waits, Christopher Mike
Mitcheson, Paul D.
Ghodssi, Reza
TI Vibration-Based Diagnostics for Rotary MEMS
SO JOURNAL OF MICROELECTROMECHANICAL SYSTEMS
LA English
DT Article
DE Non-destructive testing; rotating machine measurement; rotating machine
stability; vibration measurement
ID ROLLING ELEMENT BEARINGS; BALL-BEARINGS; MODEL; DEFECTS; EROSION;
IMPACT; SOUND
AB This paper demonstrates the use of low-cost off-the-shelf (OTS) microelectromechanical system (MEMS) technology to perform vibration-based in situ monitoring, diagnostics, and characterization of a MEMS microball bearing supported radial air turbine platform. A multimodal software suite for platform automation and sensor monitoring is demonstrated using a three-level heuristic software suite and sensor network. The vibration diagnostic methods used in the platform have applications in rotary microsystems for the early detection of failure, fault diagnosis, and integrated diagnostic systems for feedback-based optimization to increase device performance, reliability, and operational lifetimes. The studied rotary microdevice used a dual OTS accelerometer configuration for dual range parallel redundant vibration analysis. The sensor suite has been used to monitor and detect multiple operational parameters measured optimally in time or frequency domains such as rotor instability, imbalance, wobble, and system resonance. This paper will lay the framework for active diagnostics in future MEMS devices through integrated systems.
C1 [Feldman, Jeremy; Misra, Saswat; Fan, Xiao Zhu; Ghodssi, Reza] Univ Maryland, Dept Elect & Comp Engn, Syst Res Inst, College Pk, MD 20742 USA.
[Hanrahan, Brendan Michael] Univ Maryland, Dept Mat Sci & Engn, College Pk, MD 20742 USA.
[Waits, Christopher Mike] US Army Res Lab, Adelphi, MD 20783 USA.
[Mitcheson, Paul D.] Univ London Imperial Coll Sci Technol & Med, Dept Elect & Elect Engn, London SW7 2AZ, England.
RP Feldman, J (reprint author), Univ Maryland, Dept Elect & Comp Engn, Syst Res Inst, College Pk, MD 20742 USA.
EM jerplane@gmail.com; brendan.m.hanrahan.ctr@mail.mil;
smisra8@terpmail.umd.edu; xiaozfan@gmail.com;
christopher.m.waits.civ@mail.mil; paul.mitcheson@imperial.ac.uk;
ghodssi@umd.edu
FU U.S. National Science Foundation [0901411]
FX This work was supported by the U.S. National Science Foundation under
Award 0901411.
NR 33
TC 1
Z9 1
U1 3
U2 22
PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
PI PISCATAWAY
PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA
SN 1057-7157
EI 1941-0158
J9 J MICROELECTROMECH S
JI J. Microelectromech. Syst.
PD APR
PY 2015
VL 24
IS 2
BP 289
EP 299
DI 10.1109/JMEMS.2014.2383171
PG 11
WC Engineering, Electrical & Electronic; Nanoscience & Nanotechnology;
Instruments & Instrumentation; Physics, Applied
SC Engineering; Science & Technology - Other Topics; Instruments &
Instrumentation; Physics
GA CF1BI
UT WOS:000352278200007
ER
PT J
AU Tragord, BS
Bui-Mansfield, LT
Croy, T
Shaffer, SW
AF Tragord, Bradley S.
Bui-Mansfield, Liem T.
Croy, Theodore
Shaffer, Scott W.
TI Suprascapular Neuropathy After Distal Clavicle Resection and
Coracoclavicular Ligament Reconstruction: A Resident's Case Problem
SO JOURNAL OF ORTHOPAEDIC & SPORTS PHYSICAL THERAPY
LA English
DT Article
DE acromioclavicular joint; electromyography; infraspinatus; nerve injury;
scapula
ID EXCISION; COMPLICATIONS; METAANALYSIS; DIAGNOSIS; ACCURACY; TEARS; MRI
AB STUDY DESIGN: Resident's case problem.
BACKGROUND: Acromioclavicular joint pathology is reported to be present in up to 30% of all patients complaining of shoulder dysfunction. The operative approach to treating acromioclavicular joint disease often includes a distal clavicle excision and, in circumstances of acromioclavicular joint instability, reconstruction of the coracoclavicular and/or the acromioclavicular ligament. Surgical complications for these procedures are rare, but potentially include suprascapular neuropathy secondary to the course of the suprascapular nerve posterior to the clavicle prior to entering the supraspinatus fossa.
DIAGNOSIS: A 28-year-old Caucasian woman reported directly to an outpatient physical therapy clinic with a complaint of right shoulder weakness. Three years prior, the patient underwent a distal clavicle excision and coracoclavicular ligament reconstruction. A detailed examination, including diagnostic imaging, identified infraspinatus atrophy and weakness, increasing the suspicion for suprascapular nerve injury. Electromyography was ordered to confirm the clinical and imaging diagnosis of suprascapular neuropathy and to rule out other nerve lesions, especially considering the selective atrophy of the infraspinatus muscle without mechanical explanation.
DISCUSSION: The clinical decision making and systematic use of diagnostic testing resulted in identifying a rare case of suprascapular neuropathy, selective to the infraspinatus, in a patient who previously underwent a distal clavicle excision and coracoclavicular ligament reconstruction. Without a spinoglenoid cyst or other suprascapular nerve lesion identified on advanced imaging, it is likely that the suprascapular neuropathy identified in this case was related to the Surgical procedure.
C1 [Tragord, Bradley S.] Brooke Army Med Ctr, US Army Baylor Univ Doctoral Fellowship Orthopaed, Ft Sam Houston, TX 78234 USA.
[Bui-Mansfield, Liem T.] Brooke Army Med Ctr, Uniformed Serv Univ Hlth Sci, Ft Sam Houston, TX 78234 USA.
[Croy, Theodore; Shaffer, Scott W.] US Army Baylor Doctoral Program Phys Therapy, Ft Sam Houston, TX USA.
RP Tragord, BS (reprint author), Brooke Army Med Ctr, Dept Rehabil, Phys Therapy Serv, Bldg 1179, Ft Sam Houston, TX 78234 USA.
EM bradley.s.tragord.mil@mail.mil
NR 21
TC 1
Z9 1
U1 1
U2 3
PU J O S P T,
PI ALEXANDRIA
PA 1111 NORTH FAIRFAX ST, STE 100, ALEXANDRIA, VA 22314-1436 USA
SN 0190-6011
J9 J ORTHOP SPORT PHYS
JI J. Orthop. Sports Phys. Ther.
PD APR
PY 2015
VL 45
IS 4
BP 299
EP 305
DI 10.2519/jospt.2015.5416
PG 7
WC Orthopedics; Rehabilitation; Sport Sciences
SC Orthopedics; Rehabilitation; Sport Sciences
GA CE9RE
UT WOS:000352180300009
PM 25579694
ER
PT J
AU Beers, LR
Mabry, LM
Sullivan, RT
AF Beers, Lauren R.
Mabry, Lance M.
Sullivan, Robert T.
TI Osseous Fragment in a Patient With Knee Pain
SO JOURNAL OF ORTHOPAEDIC & SPORTS PHYSICAL THERAPY
LA English
DT Editorial Material
C1 [Beers, Lauren R.] US Army Baylor Univ, Doctoral Program Phys Therapy, Ft Sam Houston, TX 78234 USA.
RP Beers, LR (reprint author), US Army Baylor Univ, Doctoral Program Phys Therapy, Ft Sam Houston, TX 78234 USA.
NR 1
TC 0
Z9 0
U1 0
U2 0
PU J O S P T,
PI ALEXANDRIA
PA 1111 NORTH FAIRFAX ST, STE 100, ALEXANDRIA, VA 22314-1436 USA
SN 0190-6011
J9 J ORTHOP SPORT PHYS
JI J. Orthop. Sports Phys. Ther.
PD APR
PY 2015
VL 45
IS 4
BP 323
EP 323
PG 1
WC Orthopedics; Rehabilitation; Sport Sciences
SC Orthopedics; Rehabilitation; Sport Sciences
GA CE9RE
UT WOS:000352180300012
PM 25827125
ER
PT J
AU Agha, M
Augustine, B
Lovich, JE
Delaney, D
Sinervo, B
Murphy, MO
Ennen, JR
Briggs, JR
Cooper, R
Price, SJ
AF Agha, Mickey
Augustine, Benjamin
Lovich, Jeffrey E.
Delaney, David
Sinervo, Barry
Murphy, Mason O.
Ennen, Joshua R.
Briggs, Jessica R.
Cooper, Robert
Price, Steven J.
TI Using motion-sensor camera technology to infer seasonal activity and
thermal niche of the desert tortoise (Gopherus agassizii)
SO JOURNAL OF THERMAL BIOLOGY
LA English
DT Article
DE Resource Selection Functions; Desert southwest; Climate change; Normal
mixture models; Wildlife management
ID WIND-ENERGY FACILITY; GENERALIZED ESTIMATING EQUATIONS; AKAIKES
INFORMATION CRITERION; TURTLE PSEUDEMYS-SCRIPTA; BASKING BEHAVIOR;
BODY-TEMPERATURE; SOUTHERN CALIFORNIA; CLIMATIC VARIATION; WILDLIFE
RESEARCH; ACTIVITY PATTERNS
AB Understanding the relationships between environmental variables and wildlife activity is an important part of effective management. The desert tortoise (Gopherus agassizii), an imperiled species of arid environments in the southwest US, may have increasingly restricted windows for activity due to current warming trends. In summer 2013, we deployed 48 motion sensor cameras at the entrances of tortoise burrows to investigate the effects of temperature, sex, and day of the year on the activity of desert tortoises. Using generalized estimating equations, we found that the relative probability of activity was associated with temperature (linear and quadratic), sex, and day of the year. Sex effects showed that male tortoises are generally more active than female tortoises. Temperature had a quadratic effect, indicating that tortoise activity was heightened at a range of temperatures. In addition, we found significant support for interactions between sex and day of the year, and sex and temperature as predictors of the probability of activity. Using our models, we were able to estimate air temperatures and times (days and hours) that were associated with maximum activity during the study. Because tortoise activity is constrained by environmental conditions such as temperature, it is increasingly vital to conduct studies on how tortoises vary their activity throughout the Sonoran Desert to better understand the effects of a changing climate. (C) 2015 Elsevier Ltd. All rights reserved.
C1 [Agha, Mickey; Price, Steven J.] Univ Kentucky, Dept Forestry, Lexington, KY 40546 USA.
[Augustine, Benjamin] Virginia Tech, Dept Fish & Wildlife Conservat, Blacksburg, VA 24061 USA.
[Lovich, Jeffrey E.] US Geol Survey, Southwest Biol Sci Ctr, Flagstaff, AZ 86001 USA.
[Delaney, David] US Army, Construct Engn Res Lab, Champaign, IL 61826 USA.
[Sinervo, Barry; Cooper, Robert] Univ Calif Santa Cruz, Dept Ecol & Evolutionary Biol, Santa Cruz, CA 95064 USA.
[Murphy, Mason O.] Univ Kentucky, Dept Biol, Lexington, KY 40546 USA.
[Ennen, Joshua R.] Tennessee Aquarium Conservat Inst, Chattanooga, TN 37402 USA.
[Briggs, Jessica R.] Colorado State Univ, Warner Coll Nat Resources, Ft Collins, CO 80523 USA.
RP Price, SJ (reprint author), Univ Kentucky, Dept Forestry, Lexington, KY 40546 USA.
EM mickey.agha@uky.edu; ben.augustine@uky.edu; jeffrey_lovich@usgs.gov;
David.Delaney@usace.army.mil; lizardrps@gmail.com; mason.murphy@uky.edu;
jre@tnaqua.org; jessiebriggs13@gmail.com; rdcooper408@gmail.com;
steven.price@uky.edu
OI Lovich, Jeffrey/0000-0002-7789-2831; Agha, Mickey/0000-0003-0961-8344
FU California Energy Commission-Public Interest Energy Research Program
[500-09-020]; Bureau of Land Management; University of Kentucky -
Department of Forestry; California Desert Managers Group; Desert Legacy
Fund of the California Desert Research Program
FX Our research at the site has been supported at various times by the
California Energy Commission-Public Interest Energy Research Program
(Contract # 500-09-020), the Bureau of Land Management, the University
of Kentucky - Department of Forestry, the California Desert Managers
Group, and the Desert Legacy Fund of the California Desert Research
Program. Research was conducted under permits from the United States
Fish and Wildlife Service, California Department of Fish and Wildlife,
and the Bureau of Land Management. We acknowledge B. Todd of the
University of California, Davis, R. Huey of the University of
Washington, and anonymous peer reviewers for valuable comments and
critical reading of earlier versions of the manuscript. Special thanks
are given to A. Muth of the Boyd Deep Canyon Desert Research Center of
the University of California, Riverside, for providing accommodations
during our research. Any use of trade, product, or firm names is for
descriptive purposes only and does not imply endorsement by the U.S.
Government.
NR 94
TC 2
Z9 2
U1 6
U2 31
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4565
J9 J THERM BIOL
JI J. Therm. Biol.
PD APR-MAY
PY 2015
VL 49-50
BP 119
EP 126
DI 10.1016/j.jtherbio.2015.02.009
PG 8
WC Biology; Zoology
SC Life Sciences & Biomedicine - Other Topics; Zoology
GA CE7RJ
UT WOS:000352039200015
PM 25774035
ER
PT J
AU Hourani, L
Bray, R
Williams, J
Wilk, J
Hoge, C
AF Hourani, Laurel
Bray, Robert
Williams, Jason
Wilk, Joshua
Hoge, Charles
TI Gender Differences in Posttraumatic Stress Disorder and Help-Seeking in
the US Army
SO JOURNAL OF WOMENS HEALTH
LA English
DT Meeting Abstract
C1 [Hourani, Laurel; Bray, Robert; Williams, Jason] RTI Int, Virginia Beach, VA USA.
[Wilk, Joshua; Hoge, Charles] Walter Reed Army Inst Res, Silver Spring, MD USA.
NR 0
TC 0
Z9 0
U1 1
U2 3
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1540-9996
EI 1931-843X
J9 J WOMENS HEALTH
JI J. Womens Health
PD APR 1
PY 2015
VL 24
IS 4
MA P48
BP 20
EP 20
PG 1
WC Public, Environmental & Occupational Health; Medicine, General &
Internal; Obstetrics & Gynecology; Women's Studies
SC Public, Environmental & Occupational Health; General & Internal
Medicine; Obstetrics & Gynecology; Women's Studies
GA CF5YE
UT WOS:000352632500049
ER
PT J
AU Camacho, M
Teixeira, J
Abdullatif, J
Acevedo, JL
Certal, V
Capasso, R
Powell, NB
AF Camacho, Macario
Teixeira, Jeffrey
Abdullatif, Jose
Acevedo, Jason L.
Certal, Victor
Capasso, Robson
Powell, Nelson B.
TI Maxillomandibular Advancement and Tracheostomy for Morbidly Obese
Obstructive Sleep Apnea: A Systematic Review and Meta-analysis
SO OTOLARYNGOLOGY-HEAD AND NECK SURGERY
LA English
DT Review
DE obstructive sleep apnea; sleep apnea syndromes; tracheostomy;
maxillomandibular advancement; morbid obesity
ID POSITIVE AIRWAY PRESSURE; TERM-FOLLOW-UP; MAXILLOFACIAL SURGERY;
SURGICAL-TREATMENT; ELECTIVE TRACHEOSTOMY; ALTERNATIVE TREATMENT;
ORTHOGNATHIC SURGERY; PICKWICKIAN-SYNDROME; CONSECUTIVE PATIENTS;
COMPUTED-TOMOGRAPHY
AB Objective The objective of this study is to systematically review polysomnography data and sleepiness in morbidly obese (body mass index [BMI] 40 kg/m(2)) patients with obstructive sleep apnea (OSA) treated with either a maxillomandibular advancement (MMA) or a tracheostomy and to evaluate the outcomes.
Data Sources MEDLINE, Scopus, Web of Science, and the Cochrane Library.
Review Methods A search was performed from inception through April 8, 2014, in each database.
Results Six maxillomandibular advancement studies (34 patients, age 42.42 9.13 years, mean BMI 44.88 +/- 4.28 kg/m(2)) and 6 tracheostomy studies (14 patients, age 52.21 +/- 10.40 years, mean BMI 47.93 +/- 7.55 kg/m(2)) reported individual patient data. The pre- and post-MMA means +/- SDs for apnea-hypopnea indices were 86.18 +/- 33.25/h and 9.16 +/- 7.89/h (P < .00001), and lowest oxygen saturations were 66.58% +/- 16.41% and 87.03% +/- 5.90% (P < .00001), respectively. Sleepiness following MMA decreased in all 5 patients for whom it was reported. The pre- and posttracheostomy mean +/- SD values for apnea indices were 64.43 +/- 41.35/h and 1.73 +/- 2.68/h (P = .0086), oxygen desaturation indices were 69.20 +/- 26.10/h and 41.38 +/- 36.28/h (P = .22), and lowest oxygen saturations were 55.17% +/- 16.46% and 79.83% +/- 4.36% (P = .011), respectively. Two studies reported outcomes for Epworth Sleepiness Scale for 5 patients, with mean +/- SD values of 18.80 +/- 4.02 before tracheostomy and 2.80 +/- 2.77 after tracheostomy (P = .0034).
Conclusion Data for MMA and tracheostomy as treatment for morbidly obese, adult OSA patients are significantly limited. We caution surgeons about drawing definitive conclusions from these limited studies; higher level studies are needed.
C1 [Camacho, Macario] Stanford Hosp & Clin, Sleep Med Div, Redwood City, CA USA.
[Teixeira, Jeffrey] US Army, Dept Otolaryngol Head & Neck Surg, Walter Reed Natl Mil Med Ctr, Bethesda, MD USA.
[Abdullatif, Jose] Hosp Bernardino Rivadavia, Dept Otorhinolaryngol, Buenos Aires, DF, Argentina.
[Acevedo, Jason L.] US Army, Dept Otolaryngol Head & Neck Surg, Reynolds Army Community Hosp, Ft Sill, OK USA.
[Certal, Victor] Hosp CUF, Sleep Med Ctr, Dept Otorhinolaryngol, Oporto, Portugal.
[Certal, Victor] Univ Porto, CINTESIS Ctr Res Hlth Technol & Informat Syst, P-4100 Oporto, Portugal.
[Capasso, Robson] Stanford Univ, Med Ctr, Dept Otolaryngol Head & Neck Surg, Sleep Surg Div, Stanford, CA 94305 USA.
[Powell, Nelson B.] Stanford Hosp & Clin, Dept Otolaryngol Head & Neck Surg, Sleep Surg Div, Stanford, CA USA.
RP Camacho, M (reprint author), US Army, Stanford Hosp & Clin, Sleep Med Div, 2nd Floor,450 Broadway St, Redwood City, CA 94063 USA.
EM drcamachoent@yahoo.com
RI FMUP, CINTESIS/C-6631-2014;
OI FMUP, CINTESIS/0000-0001-7248-2086; Certal, Victor/0000-0002-1904-9504;
Camacho, Macario/0000-0001-9200-9085
FU American Academy of Otolaryngology-Head and Neck Surgery
FX The American Academy of Otolaryngology-Head and Neck Surgery provided
support for this manuscript as the first author participated as an
AAO-HNS Cochrane Scholar and attended the 2013 Cochrane Colloquium.
NR 156
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Z9 6
U1 0
U2 7
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 0194-5998
EI 1097-6817
J9 OTOLARYNG HEAD NECK
JI Otolaryngol. Head Neck Surg.
PD APR
PY 2015
VL 152
IS 4
BP 619
EP 630
DI 10.1177/0194599814568284
PG 12
WC Otorhinolaryngology; Surgery
SC Otorhinolaryngology; Surgery
GA CF5ET
UT WOS:000352580000013
PM 25644497
ER
PT J
AU Camacho, M
Kushida, CA
Capasso, R
AF Camacho, Macario
Kushida, Clete A.
Capasso, Robson
TI 2-Year Sleep Surgery and Medicine Fellowships for Otolaryngologists
SO OTOLARYNGOLOGY-HEAD AND NECK SURGERY
LA English
DT Letter
C1 [Camacho, Macario] Tripler Army Med Ctr, Div Sleep Surg & Med, Otolaryngol Head & Neck Surg, Honolulu, HI 96859 USA.
[Kushida, Clete A.] Stanford Hosp & Clin, Dept Psychiat, Div Sleep Med, Redwood City, CA USA.
[Capasso, Robson] Stanford Univ, Med Ctr, Sleep Surg Div, Dept Otolaryngol Head & Neck Surg, Stanford, CA 94305 USA.
RP Camacho, M (reprint author), Tripler Army Med Ctr, Div Sleep Surg & Med, Otolaryngol Head & Neck Surg, Honolulu, HI 96859 USA.
OI Camacho, Macario/0000-0001-9200-9085
NR 1
TC 0
Z9 0
U1 0
U2 0
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 0194-5998
EI 1097-6817
J9 OTOLARYNG HEAD NECK
JI Otolaryngol. Head Neck Surg.
PD APR
PY 2015
VL 152
IS 4
BP 766
EP 767
DI 10.1177/0194599815574258
PG 2
WC Otorhinolaryngology; Surgery
SC Otorhinolaryngology; Surgery
GA CF5ET
UT WOS:000352580000038
PM 25833930
ER
PT J
AU Smith, IM
Beech, ZKM
Lundy, JB
Bowley, DM
AF Smith, Iain M.
Beech, Zine K. M.
Lundy, Jonathan B.
Bowley, Douglas M.
TI A Prospective Observational Study of Abdominal Injury Management in
Contemporary Military Operations Damage Control Laparotomy Is Associated
With High Survivability and Low Rates of Fecal Diversion
SO ANNALS OF SURGERY
LA English
DT Article
DE abdominal injury; anastomosis; battlefield injury; damage control
laparotomy; war surgery
ID COLON INJURIES; SEVERITY SCORE; IRAQI-FREEDOM; CONTROL SURGERY; CONTROL
RESUSCITATION; REQUIRING RESECTION; DELAYED ANASTOMOSIS; COMBAT
CASUALTIES; TRAUMA PATIENTS; PRIMARY REPAIR
AB Objective: This study describes the cause, management, and outcomes of abdominal injury in a mature deployed military trauma system, with particular focus on damage control, hollow visceral injury (HVI), and stoma utilization.
Background: Damage control laparotomy (DCL) is established in military and civilian practice. However, optimal management of HVI during military DCL remains controversial.
Methods: We studied abdominal trauma managed over 5 months at the Joint Force Combat Support Hospital, Camp Bastion, Afghanistan (Role 3). Data included demographics, wounding mechanism, injuries sustained, prehospital times, location of first laparotomy (Role 3 or forward), use of DCL or definitive laparotomy, subsequent surgical details, resource utilization, complications, and mortality.
Results: Ninety-four of 636 trauma patients (15%) underwent laparotomy. Military injury mechanisms dominated [44 gunshot wounds (47%), 44 blast (47%), and 6 blunt trauma (6%)]. Seventy-two of 94 patients (77%) underwent DCL. Four patients were palliated. Seventy of 94 (74%) sustained HVI; 44 of 70 (63%) had colonic injury. Repair or resection with anastomosis was performed in 59 of 67 therapeutically managed HVI patients (88%). Six patients were managed with fecal diversion, and 6 patients were evacuated with discontinuous bowel. Anastomotic leaks occurred in 4 of 56 HVI patients (7%) with known outcomes. Median New Injury Severity Score for DCL patients was 29 (interquartile range: 18-41) versus 19.5 (interquartile range: 12-34) for patients undergoing definitive laparotomy (P = 0.016). Overall mortality was 15 of 94 (16%).
Conclusions: Damage control is now used routinely for battlefield abdominal trauma. In a well-practiced Combat Support Hospital, this strategy is associated with low mortality and infrequent fecal diversion.
C1 [Smith, Iain M.] 202 Midlands Field Hosp, Birmingham, W Midlands, England.
[Smith, Iain M.] NIHR Surg Reconstruct & Microbiol Res Ctr, Birmingham, W Midlands, England.
[Smith, Iain M.; Bowley, Douglas M.] Royal Ctr Def Med, Birmingham, W Midlands, England.
[Lundy, Jonathan B.] US Army, Inst Surg Res, Houston, TX USA.
RP Bowley, DM (reprint author), Queen Elizabeth Hosp, Royal Ctr Def Med, Birmingham B15 2TH, W Midlands, England.
EM doug.bowley@heartofengland.nhs.uk
NR 70
TC 6
Z9 6
U1 0
U2 4
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0003-4932
EI 1528-1140
J9 ANN SURG
JI Ann. Surg.
PD APR
PY 2015
VL 261
IS 4
BP 765
EP 773
DI 10.1097/SLA.0000000000000657
PG 9
WC Surgery
SC Surgery
GA CE2VV
UT WOS:000351679500047
PM 24646559
ER
PT J
AU Luu, S
Cruz-Mora, J
Setlow, B
Feeherry, FE
Doona, CJ
Setlow, P
AF Luu, Stephanie
Cruz-Mora, Jose
Setlow, Barbara
Feeherry, Florence E.
Doona, Christopher J.
Setlow, Peter
TI The Effects of Heat Activation on Bacillus Spore Germination, with
Nutrients or under High Pressure, with or without Various Germination
Proteins
SO APPLIED AND ENVIRONMENTAL MICROBIOLOGY
LA English
DT Article
ID SUBTILIS SPORES; DIPICOLINIC ACID; INNER MEMBRANE; STEAROTHERMOPHILUS
SPORES; THERMAL STERILIZATION; CLOSTRIDIUM-BOTULINUM; FOOD QUALITY;
RECEPTORS; RESISTANCE; INACTIVATION
AB Nutrient germination of spores of Bacillus species occurs through germinant receptors (GRs) in spores' inner membrane (IM) in a process stimulated by sublethal heat activation. Bacillus subtilis spores maximum germination rates via different GRs required different 75 degrees C heat activation times: 15 min for L-valine germination via the GerA GR and 4 h for germination with the L-asparagine-glucose-fructose-K+ mixture via the GerB and GerK GRs, with GerK requiring the most heat activation. In some cases, optimal heat activation decreased nutrient concentrations for half-maximal germination rates. Germination of spores via various GRs by high pressure (HP) of 150 MPa exhibited heat activation requirements similar to those of nutrient germination, and the loss of the GerD protein, required for optimal GR function, did not eliminate heat activation requirements for maximal germination rates. These results are consistent with heat activation acting primarily on GRs. However, (i) heat activation had no effects on GR or GerD protein conformation, as probed by biotinylation by an external reagent; (ii) spores prepared at low and high temperatures that affect spores' IM properties exhibited large differences in heat activation requirements for nutrient germination; and (iii) spore germination by 550 MPa of HP was also affected by heat activation, but the effects were relatively GR independent. The last results are consistent with heat activation affecting spores' IM and only indirectly affecting GRs. The 150- and 550-MPa HP germinations of Bacillus amyloliquefaciens spores, a potential surrogate for Clostridium botulinum spores in HP treatments of foods, were also stimulated by heat activation.
C1 [Luu, Stephanie; Cruz-Mora, Jose; Setlow, Barbara; Setlow, Peter] UConn Hlth, Dept Mol Biol & Biophys, Farmington, CT 06030 USA.
[Feeherry, Florence E.; Doona, Christopher J.] US Army, Natick Soldier RD&E Ctr, Warfighter Directorate, Natick, MA USA.
RP Setlow, P (reprint author), UConn Hlth, Dept Mol Biol & Biophys, Farmington, CT 06030 USA.
EM setlow@nso2.uchc.edu
FU Department of Defense Multi-Disciplinary Research Initiative through the
U.S. Army Research Laboratory; U.S. Army Research Office
[W911NF-09-1-0286]
FX This communication is based upon work supported by a Department of
Defense Multi-Disciplinary Research Initiative through the U.S. Army
Research Laboratory and the U.S. Army Research Office under contract
number W911NF-09-1-0286.
NR 59
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U1 1
U2 24
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0099-2240
EI 1098-5336
J9 APPL ENVIRON MICROB
JI Appl. Environ. Microbiol.
PD APR
PY 2015
VL 81
IS 8
BP 2927
EP 2938
DI 10.1128/AEM.00193-15
PG 12
WC Biotechnology & Applied Microbiology; Microbiology
SC Biotechnology & Applied Microbiology; Microbiology
GA CE5BE
UT WOS:000351843900029
PM 25681191
ER
PT J
AU Chow, BJW
Small, G
Yam, Y
Chen, L
McPherson, R
Achenbach, S
Al-Mallah, M
Berman, DS
Budoff, MJ
Cademartiri, F
Callister, TQ
Chang, HJ
Cheng, VY
Chinnaiyan, K
Cury, R
Delago, A
Dunning, A
Feuchtner, G
Hadamitzky, M
Hausleiter, J
Karlsberg, RP
Kaufmann, PA
Kim, YJ
Leipsic, J
LaBounty, T
Lin, F
Maffei, E
Ralf, GL
Shaw, LJ
Villines, TC
Min, JK
AF Chow, Benjamin J. W.
Small, Gary
Yam, Yeung
Chen, Li
McPherson, Ruth
Achenbach, Stephan
Al-Mallah, Mouaz
Berman, Daniel S.
Budoff, Matthew J.
Cademartiri, Filippo
Callister, Tracy Q.
Chang, Hyuk-Jae
Cheng, Victor Y.
Chinnaiyan, Kavitha
Cury, Ricardo
Delago, Augustin
Dunning, Allison
Feuchtner, Gundrun
Hadamitzky, Martin
Hausleiter, Joerg
Karlsberg, Ronald P.
Kaufmann, Philipp A.
Kim, Yong-Jin
Leipsic, Jonathon
LaBounty, Troy
Lin, Fay
Maffei, Erica
Ralf, Gilbert L.
Shaw, Leslee J.
Villines, Todd C.
Min, James K.
CA CONFIRM Investigators
TI Prognostic and Therapeutic Implications of Statin and Aspirin Therapy in
Individuals With Nonobstructive Coronary Artery Disease Results From the
CONFIRM (Coronary CT Angiography Evaluation For Clinical Outcomes: An
International Multicenter Registry) Registry
SO ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
LA English
DT Article
DE aspirin; coronary angiography; coronary atherosclerosis; mortality;
prognosis; statin
ID ALL-CAUSE MORTALITY; RANDOMIZED CONTROLLED-TRIAL; BEAM
COMPUTED-TOMOGRAPHY; LIFE-STYLE BEHAVIORS; HEART-DISEASE; CARDIOVASCULAR
EVENTS; PRIMARY PREVENTION; HYPERTENSIVE PATIENTS; DIAGNOSTIC-ACCURACY;
CHOLESTEROL LEVELS
AB Objective-We sought to examine the risk of mortality associated with nonobstructive coronary artery disease (CAD) and to determine the impact of baseline statin and aspirin use on mortality.
Approach and Results-Coronary computed tomographic angiography permits direct visualization of nonobstructive CAD. To date, the prognostic implications of nonobstructive CAD and the potential benefit of directing therapy based on nonobstructive CAD have not been carefully examined. A total of 27 125 consecutive patients who underwent computed tomographic angiography (12 enrolling centers and 6 countries) were prospectively entered into the COronary CT Angiography EvaluatioN For Clinical Outcomes: An InteRnational Multicenter (CONFIRM) registry. Patients, without history of previous CAD or obstructive CAD, for whom baseline statin and aspirin use was available were analyzed. Each coronary segment was classified as normal or nonobstructive CAD (1%-49% stenosis). Patients were followed up for a median of 27.2 months for all-cause mortality. The study comprised 10 418 patients (5712 normal and 4706 with nonobstructive CAD). In multivariable analyses, patients with nonobstructive CAD had a 6% (95% confidence interval, 1%-12%) higher risk of mortality for each additional segment with nonobstructive plaque (P= 0.021). Baseline statin use was associated with a reduced risk of mortality (hazard ratio, 0.44; 95% confidence interval, 0.28-0.68; P= 0.0003), a benefit that was present for individuals with nonobstructive CAD (hazard ratio, 0.32; 95% confidence interval, 0.190.55; P< 0.001) but not for those without plaque (hazard ratio, 0.66; 95% confidence interval, 0.30-1.43; P= 0.287). When stratified by National Cholesterol Education Program/Adult Treatment Program III, no mortality benefit was observed in individuals without plaque. Aspirin use was not associated with mortality benefit, irrespective of the status of plaque.
Conclusions-The presence and extent of nonobstructive CAD predicted mortality. Baseline statin therapy was associated with a significant reduction in mortality for individuals with nonobstructive CAD but not for individuals without CAD.
C1 [Chow, Benjamin J. W.; Small, Gary; Yam, Yeung; Chen, Li; McPherson, Ruth] Univ Ottawa, Inst Heart, Dept Med Cardiol, Ottawa, ON, Canada.
[Achenbach, Stephan] Univ Erlangen Nurnberg, Dept Med, D-91054 Erlangen, Germany.
[Al-Mallah, Mouaz] Wayne State Univ, Dept Med, Henry Ford Hosp, Detroit, MI 48202 USA.
[Berman, Daniel S.; Cheng, Victor Y.; LaBounty, Troy] Cedars Sinai Med Ctr, Dept Imaging, Los Angeles, CA 90048 USA.
[Budoff, Matthew J.] Harbor Univ Calif, Los Angeles Med Ctr, Dept Med, Los Angeles, CA USA.
[Cademartiri, Filippo; Maffei, Erica] Giovanni XXIII Hosp, Dept Radiol, Monastier Di Treviso, Italy.
[Cademartiri, Filippo; Maffei, Erica] Erasmus MC, Dept Radiol, Rotterdam, Netherlands.
[Callister, Tracy Q.] Tennessee Heart & Vasc Inst, Hendersonville, NC USA.
[Chang, Hyuk-Jae] Severance Cardiovasc Hosp, Div Cardiol, Seoul, South Korea.
[Chinnaiyan, Kavitha] William Beaumont Hosp, Royal Oak, MI USA.
[Cury, Ricardo] Baptist Cardiac & Vasc Inst, Miami, FL USA.
[Delago, Augustin] Capitol Cardiol Associates, Albany, NY USA.
[Dunning, Allison] New York Presbyterian Hosp, Dept Publ Hlth, New York, NY 10021 USA.
[Lin, Fay] New York Presbyterian Hosp, Dept Med & Radiol, New York, NY 10021 USA.
[Min, James K.] New York Presbyterian Hosp, Dept Radiol, New York, NY 10021 USA.
Weill Cornell Med Coll, New York, NY USA.
[Feuchtner, Gundrun] Med Univ Innsbruck, Dept Radiol, A-6020 Innsbruck, Austria.
[Hadamitzky, Martin; Hausleiter, Joerg] Tech Univ Munich, Div Cardiol, D-80290 Munich, Germany.
[Karlsberg, Ronald P.] Cardiovasc Med Grp, Los Angeles, CA USA.
[Kaufmann, Philipp A.] Univ Zurich Hosp, Cardiac Imaging, CH-8091 Zurich, Switzerland.
[Kim, Yong-Jin] Seoul Natl Univ Hosp, Seoul 110744, South Korea.
[Leipsic, Jonathon] Univ British Columbia, Dept Med & Radiol, Vancouver, BC V5Z 1M9, Canada.
[Ralf, Gilbert L.] William Beaumont Hosp, Dept Cardiol, Royal Oak, MI USA.
[Shaw, Leslee J.] Emory Univ, Sch Med, Dept Med, Atlanta, GA USA.
[Villines, Todd C.] Walter Reed Army Med Ctr, Dept Med, Washington, DC 20307 USA.
RP Min, JK (reprint author), New York Presbyterian Hosp, Weill Cornell Med Coll, 413 E 69th St,Suite 108, New York, NY 10021 USA.
EM jkm2001@med.cornell.edu
RI Maffei, Erica/J-2370-2016; Cademartiri, Filippo/H-7336-2015
OI Maffei, Erica/0000-0002-0388-4433; Cademartiri,
Filippo/0000-0002-0579-3279
FU Heart Lung and Blood Institute of the National Institutes of Health
[1R01HL115150, R0HL118019]; Leading Foreign Research Institute,
Recruitment Program through the National Research Foundation of Korea
(NRF) - Ministry of Science, ICT & Future Planning (MSIP) [2012027176];
Dalio Institute of Cardiovascular Imaging; Michael Wolk Foundation
FX Research reported in this publication was supported by the Heart Lung
and Blood Institute of the National Institutes of Health under award
numbers 1R01HL115150 and R011HL118019. The content is solely the
responsibility of the authors and does not necessarily represent the
official views of the National Institutes of Health. This research was
also supported by Leading Foreign Research Institute, Recruitment
Program through the National Research Foundation of Korea (NRF) funded
by the Ministry of Science, ICT & Future Planning (MSIP; 2012027176).
This study was also funded, in part, by a generous gift from the Dalio
Institute of Cardiovascular Imaging and the Michael Wolk Foundation.
NR 37
TC 19
Z9 19
U1 3
U2 8
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1079-5642
EI 1524-4636
J9 ARTERIOSCL THROM VAS
JI Arterioscler. Thromb. Vasc. Biol.
PD APR
PY 2015
VL 35
IS 4
BP 981
EP U271
DI 10.1161/ATVBAHA.114.304351
PG 12
WC Hematology; Peripheral Vascular Disease
SC Hematology; Cardiovascular System & Cardiology
GA CE3EQ
UT WOS:000351709200030
PM 25676000
ER
PT J
AU Arwady, MA
Bawo, L
Hunter, JC
Massaquoi, M
Matanock, A
Dahn, B
Ayscue, P
Nyenswah, T
Forrester, JD
Hensley, LE
Monroe, B
Schoepp, RJ
Chen, TH
Schaecher, KE
George, T
Rouse, E
Schafer, IJ
Pillai, SK
De Cock, KM
AF Arwady, M. Allison
Bawo, Luke
Hunter, Jennifer C.
Massaquoi, Moses
Matanock, Almea
Dahn, Bernice
Ayscue, Patrick
Nyenswah, Tolbert
Forrester, Joseph D.
Hensley, Lisa E.
Monroe, Benjamin
Schoepp, Randal J.
Chen, Tai-Ho
Schaecher, Kurt E.
George, Thomas
Rouse, Edward
Schafer, Ilana J.
Pillai, Satish K.
De Cock, Kevin M.
TI Evolution of Ebola Virus Disease from Exotic Infection to Global Health
Priority, Liberia, Mid-2014
SO EMERGING INFECTIOUS DISEASES
LA English
DT Article
AB Over the span of a few weeks during July and August 2014, events in West Africa changed perceptions of Ebola virus disease (EVD) from an exotic tropical disease to a priority for global health security. We describe observations during that time of a field team from the Centers for Disease Control and Prevention and personnel of the Liberian Ministry of Health and Social Welfare. We outline the early epidemiology of EVD within Liberia, including the practical limitations on surveillance and the effect on the country's health care system, such as infections among health care workers. During this time, priorities included strengthening EVD surveillance; establishing safe settings for EVD patient care (and considering alternative isolation and care models when Ebola Treatment Units were overwhelmed); improving infection control practices; establishing an incident management system; and working with Liberian airport authorities to implement EVD screening of departing passengers.
C1 [Arwady, M. Allison; Hunter, Jennifer C.; Matanock, Almea; Ayscue, Patrick; Forrester, Joseph D.; Monroe, Benjamin; Chen, Tai-Ho; George, Thomas; Rouse, Edward; Schafer, Ilana J.; Pillai, Satish K.; De Cock, Kevin M.] Ctr Dis Control & Prevent, Atlanta, GA 30329 USA.
[Bawo, Luke; Massaquoi, Moses; Dahn, Bernice; Nyenswah, Tolbert] Minist Hlth & Social Welf, Monrovia, Liberia.
[Hensley, Lisa E.] Natl Inst Hlth, Bethesda, MD USA.
[Schoepp, Randal J.; Schaecher, Kurt E.] US Army Med Res Inst Infect Dis, Frederick, MD USA.
RP Arwady, MA (reprint author), Ctr Dis Control & Prevent, 1600 Clifton Rd NE,Mailstop E92, Atlanta, GA 30329 USA.
EM xdr3@cdc.gov
NR 5
TC 13
Z9 14
U1 3
U2 52
PU CENTERS DISEASE CONTROL
PI ATLANTA
PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA
SN 1080-6040
EI 1080-6059
J9 EMERG INFECT DIS
JI Emerg. Infect. Dis
PD APR
PY 2015
VL 21
IS 4
BP 578
EP 584
DI 10.3201/eid2104.141940
PG 7
WC Immunology; Infectious Diseases
SC Immunology; Infectious Diseases
GA CE2NK
UT WOS:000351652100004
PM 25811176
ER
PT J
AU Estenoz, S
Bush, E
AF Estenoz, Shannon
Bush, Eric
TI Everglades Restoration Science and Decision-Making in the Face of
Climate Change: A Management Perspective
SO ENVIRONMENTAL MANAGEMENT
LA English
DT Article
DE Everglades; Everglades restoration; Climate change; Science and
decision-making; Large-scale ecosystem restoration
AB Managers were invited to attend the two-day "Predicting Ecological Changes in the Florida Everglades in a Future Climate Scenario" workshop and to participate in discussion and panel sessions. This paper provides a management perspective on the technical presentations presented at the workshop, identifying information of particular interest to Everglades restoration decision-making. In addition, the paper highlights the points related to science and decision-making that emerged from the discussion sessions and provides thoughts for future discussion in a follow-up forum. Particular focus is dedicated to the importance of and challenges associated with integrating science and decision-making. In addition, the paper offers a management perspective on the uncertainties of climate science and the implications they have for influencing Everglades restoration decision-making. The authors propose that on the one hand, even given uncertainties associated with predicting the ecological response to climate change, there remains a scientific consensus that Everglades restoration is generally on the right track. On the other hand, uncertainty can be a significant barrier to climate science influencing the implementation of restoration and adaptive management programs.
C1 [Estenoz, Shannon] US Dept Interior, Off Everglades Restorat Initiat, Davie, FL 33314 USA.
[Bush, Eric] US Army Corps Engineers, Planning & Policy Div, Jacksonville, FL USA.
RP Estenoz, S (reprint author), US Dept Interior, Off Everglades Restorat Initiat, Davie, FL 33314 USA.
EM shannon_estenoz@ios.doi.gov; eric.l.bush@usace.army.mil
NR 19
TC 3
Z9 3
U1 1
U2 15
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0364-152X
EI 1432-1009
J9 ENVIRON MANAGE
JI Environ. Manage.
PD APR
PY 2015
VL 55
IS 4
BP 876
EP 883
DI 10.1007/s00267-015-0452-x
PG 8
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA CE4ZD
UT WOS:000351838300010
PM 25790777
ER
PT J
AU Cole, WC
Balent, EM
Masella, PC
Kajiura, LN
Matsumoto, KW
Pierce, LM
AF Cole, William C.
Balent, Eric M.
Masella, Pamela C.
Kajiura, Lauren N.
Matsumoto, Karen W.
Pierce, Lisa M.
TI An experimental comparison of the effects of bacterial colonization on
biologic and synthetic meshes
SO HERNIA
LA English
DT Article
DE Ventral hernia; Contaminated field; Biologic mesh; Synthetic mesh;
Staphylococcus aureus; Escherichia coli
ID VENTRAL HERNIA REPAIR; ABDOMINAL-WALL RECONSTRUCTION; IN-VIVO;
INCISIONAL HERNIA; DEFECTS; MATRIX; COLLAGEN; OUTCOMES; FIELDS
AB Biologic meshes are being used with increasing frequency to repair contaminated abdominal wall defects despite high long-term recurrence and infection rates associated with their use. Recent clinical reports describing the success of lightweight, macroporous synthetic meshes in contaminated ventral hernia repairs have led some surgeons to challenge the belief that synthetics are contraindicated in contaminated fields. We aimed to determine whether a frequently used biologic mesh (Strattice(TM)) is more resistant to bacterial colonization than macroporous synthetic mesh (Parietex(TM) Progrip(TM)) after inoculation with two common pathogens.
Rats (n = 48) were implanted subcutaneously with Strattice(TM) or Progrip(TM). Meshes were inoculated with sterile saline or a suspension containing 10(6) colony-forming units of Staphylococcus aureus or Escherichia coli prior to wound closure (n = 8 per subgroup). Meshes were explanted at 4 weeks and underwent microbiologic and histologic analyses.
Progrip(TM) demonstrated superior bacterial clearance compared to Strattice(TM) (E. coli, 88 vs. 17 % clearance, p = 0.03; S. aureus, 75 vs. 50 %, p = 0.61; combined bacterial strains, 81 vs. 36 %, p = 0.02; respectively). In the Strattice(TM) group, severely degraded meshes were observed in 100 % of animals inoculated with E. coli (but 0 % inoculated with S. aureus). In contrast, all Progrip(TM) meshes remained intact regardless of inoculum. Scores for neovascularization were higher in the synthetic group irrespective of contamination (p < 0.05).
Biologic meshes may not be more resistant to bacterial colonization than reduced-weight synthetics, and their resistance may differ in response to different pathogens. The routine use of biologics in contaminated ventral hernia repair should be questioned, particularly in the presence of E. coli.
C1 [Cole, William C.; Balent, Eric M.; Masella, Pamela C.] Tripler Army Med Ctr, Dept Gen Surg, Honolulu, HI 96859 USA.
[Kajiura, Lauren N.; Matsumoto, Karen W.; Pierce, Lisa M.] Tripler Army Med Ctr, Dept Clin Invest, Honolulu, HI 96859 USA.
RP Pierce, LM (reprint author), Tripler Army Med Ctr, Dept Clin Invest, 1 Jarrett White Rd, Honolulu, HI 96859 USA.
EM lisa.m.pierce.civ@mail.mil
FU Department of Clinical Investigation at Tripler Army Medical Center
FX This work was supported using internal funds from the Department of
Clinical Investigation at Tripler Army Medical Center. The Strattice
(TM) and Progrip (TM) mesh materials used in this study were purchased
by the authors' institution.
NR 27
TC 9
Z9 9
U1 1
U2 3
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1265-4906
EI 1248-9204
J9 HERNIA
JI Hernia
PD APR
PY 2015
VL 19
IS 2
BP 197
EP 205
DI 10.1007/s10029-014-1290-0
PG 9
WC Surgery
SC Surgery
GA CE3BS
UT WOS:000351699800005
PM 25081838
ER
PT J
AU Herrera, CJ
Owens, GP
AF Herrera, Catherine J.
Owens, Gina P.
TI Multicultural Personality and Posttraumatic Stress in US Service Members
SO JOURNAL OF CLINICAL PSYCHOLOGY
LA English
DT Article
DE military; posttraumatic stress disorder; multicultural personality
characteristics; Iraq and Afghanistan
ID MENTAL-HEALTH PROBLEMS; QUESTIONNAIRE; IRAQ; AFGHANISTAN; RESILIENCE;
VALIDITY; COMBAT; PTSD; CARE
AB ObjectiveModern military missions place numerous demands on service members, including tactical, personal, and cultural challenges. The purpose of this study was to explore how domains of multicultural personality (cultural empathy, open-mindedness, social initiative, emotional stability, and flexibility) and combat exposure relate to posttraumatic stress disorder (PTSD) in service members.
MethodParticipants (N = 163) completed the Multicultural Personality Questionnaire, Combat Exposure Scale, and PTSD Checklist-Military as part of an online survey. The majority of participants were Caucasian (87%), mean age was 33 years, and all were deployed at least once to Iraq or Afghanistan
ResultsRegression results indicated that higher levels of combat exposure and open-mindedness and lower levels of flexibility and emotional stability were significant predictors of higher PTSD severity. The interactions between combat exposure and flexibility and combat exposure and openness were also significant.
ConclusionHigher levels of flexibility and emotional stability seem particularly important in their association with lower PTSD severity for service members. (C) 2014 Wiley Periodicals, Inc.
C1 [Herrera, Catherine J.] JFK Special Warfare Ctr & Sch, Ft Bragg, NC USA.
[Owens, Gina P.] Univ Tennessee, Knoxville, TN 37996 USA.
RP Owens, GP (reprint author), Univ Tennessee, Dept Psychol, 1404 Circle Dr, Knoxville, TN 37996 USA.
EM gowens4@utk.edu
NR 29
TC 1
Z9 1
U1 0
U2 8
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0021-9762
EI 1097-4679
J9 J CLIN PSYCHOL
JI J. Clin. Psychol.
PD APR
PY 2015
VL 71
IS 4
BP 323
EP 333
DI 10.1002/jclp.22138
PG 11
WC Psychology, Clinical
SC Psychology
GA CE2VT
UT WOS:000351679300004
PM 25534149
ER
PT J
AU Rushing, TW
Howard, IL
AF Rushing, Timothy W.
Howard, Isaac L.
TI Prediction of soil deformation beneath temporary airfield matting
systems based on full-scale testing
SO JOURNAL OF TERRAMECHANICS
LA English
DT Article
DE Airfield mat; Full-scale test; Subgrade deformation; Aluminum mat; Mat;
Structural mat; Temporary pavement
AB This paper presents results from full-scale evaluations of an aluminum structural mat system with regard to carrying heavy aircraft across graded, but unimproved, soil with California Bearing Ratios (CBRs) of 6, 10, 15, 25, and 100. The objective was to determine relationships among soil deformation rate, the mat's flexural modulus, the number of applied passes, and the underlying soil's CBR. Current prevailing performance prediction models for aluminum mat systems are based on full-scale tests using historic aircraft loads over soils having a CBR of 4 that were never validated for soils with higher CBR values. Full-scale test results presented herein demonstrated the inability of current models to accurately predict mat permanent deformation. Strong correlations were found between measured and predicted data across the entire spectrum of soil CBRs. These relationships can be used to noticeably improve the accuracy of performance prediction models. An empirical equation was developed to reasonably predict subgrade deformation for any number of passes and soil CBR for the loading and mat system tested. Published by Elsevier Ltd. on behalf of ISTVS.
C1 [Rushing, Timothy W.] US Army ERDC, Vicksburg, MS 39180 USA.
[Rushing, Timothy W.; Howard, Isaac L.] Dept Civil & Environm Engn, Mississippi State, MS 39762 USA.
RP Rushing, TW (reprint author), US Army ERDC, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA.
EM Timothy.W.Rushing@usace.army.mil; ILHoward@cee.msstate.edu
FU Air Force Civil Engineer Center (AFCEC); Geotechnical and Structures
Laboratory, US Army ERDC
FX The full-scale experiments and resulting data presented in this paper
were obtained from research conducted at the US Army ERDC, Geotechnical
Laboratory, Airfields and Pavements Branch with funds provided by the
Air Force Civil Engineer Center (AFCEC). The sponsor determined the
scope of the study but did not assist in data collection, analysis, or
writing. The support of AFCEC and ERDC personnel is gratefully
acknowledged. Permission to publish this work was granted by the
Director, Geotechnical and Structures Laboratory, US Army ERDC.
NR 22
TC 2
Z9 2
U1 2
U2 8
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0022-4898
EI 1879-1204
J9 J TERRAMECHANICS
JI J. Terramech.
PD APR
PY 2015
VL 58
BP 1
EP 9
DI 10.1016/j.jterra.2014.12.004
PG 9
WC Engineering, Environmental
SC Engineering
GA CE4KT
UT WOS:000351800200001
ER
PT J
AU Raymond, JB
Jayakumar, P
AF Raymond, Joseph B.
Jayakumar, Paramsothy
TI The shearing edge of tracked vehicle - Soil interactions in path
clearing applications utilizing Multi-Body Dynamics modeling &
simulation
SO JOURNAL OF TERRAMECHANICS
LA English
DT Article
DE Terramechanics; Soft-soil mobility; Coulomb soil theory; Tracked vehicle
mobility; Design comparison; Terzaghi passive soil failure; Flail route
clearance implement; Roller-rake route clearance implement
AB Tracked vehicle soil interactions were modeled and analyzed to compare the mobility of two notional path clearing implements pushed by a tracked vehicle. This exploration assesses the capabilities and limitations of the state-of-the-art in tracked vehicle dynamics modeling and simulation over soft-soil terrain. Unique modeling and simulation methods to stretch the capability of the current state-of-the-art contribute to the overall discussion. One path clearing implement was a roller and rake combination. The other was a quickly rotating flail system that cleared a definitive path by impacting and flinging the soil away. Geotechnical forcing functions implemented Coulomb's lateral earth pressure theory and Terzaghi passive soil failure models to compute the forces at the soft-soil implement interfaces. Coulomb theory was reimagined to account for anomalies present when modeling the flail, mainly its arced motion and non-semi-infinite soil resistance zone. The path-clearing implements were simulated over discrete events and compared by means of load and acceleration time histories. The discrete events include side-slopes, grades, half-rounds, potholes, cross country terrain, and 'V' shaped ditches (V-ditch). Overall, the flail system experienced lower peak loads at the interface brackets and lower peak accelerations at the vehicle's center of gravity than the roller-rake system. Published by Elsevier Ltd. on behalf of ISTVS.
C1 [Raymond, Joseph B.; Jayakumar, Paramsothy] US Army TARDEC, Warren, MI 48092 USA.
RP Raymond, JB (reprint author), US Army TARDEC, Mail Stop 157,6501 E 11 Mile Rd, Warren, MI 48092 USA.
EM joseph.b.raymond.civ@mail.mil
NR 8
TC 1
Z9 1
U1 5
U2 18
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0022-4898
EI 1879-1204
J9 J TERRAMECHANICS
JI J. Terramech.
PD APR
PY 2015
VL 58
BP 39
EP 50
DI 10.1016/j.jterra.2014.12.003
PG 12
WC Engineering, Environmental
SC Engineering
GA CE4KT
UT WOS:000351800200004
ER
PT J
AU Diaz-Alvarez, H
Picucci, JR
McKenna, MH
Lampo, RG
AF Diaz-Alvarez, Henry
Picucci, Jenifer R.
McKenna, Mihan House
Lampo, Richard G.
TI Structural response of a recycled thermoplastic lumber bridge under
civilian and military loads
SO JOURNAL OF THERMOPLASTIC COMPOSITE MATERIALS
LA English
DT Article
DE Thermoplastic bridge; recycled plastic; bridge load rating; military
load classification (MLC); finite element model; bridge load test
AB The U.S. Army Engineer Research and Development Center (ERDC) executed a load test and verification simulation on a novel thermoplastic composite bridge, T-8518, located on Tuckers Road in Camp Mackall, North Carolina. The bridge was made with 94% recycled plastic material, primarily recycled high-density polyethylene. An M1 Abrams battle tank and a loaded dump truck were used as a live load to determine the appropriate military load classification (MLC) and civilian load rating for the bridge superstructure. The bridge was designed to support the M1 Abrams battle tank with a gross weight of 63.5 tones to replace a dilapidated timber bridge that, because of its condition, was limited to a maximum load of 4.26 tones. A finite element analysis (FEA) of the entire superstructure based on the load test results indicated that the bridge exceeded design specifications and performed in a normal linear-elastic manner with relatively small viscoelastic responses for all loads.
C1 [Diaz-Alvarez, Henry; Picucci, Jenifer R.; McKenna, Mihan House] US Army Engineer Res & Dev Ctr, Geotech & Struct Lab, Vicksburg, MS 39180 USA.
[Lampo, Richard G.] US Army Engineer Res & Dev Ctr, Construct Engn Res Lab, Champaign, IL USA.
RP Diaz-Alvarez, H (reprint author), US Army Engineer Res & Dev Ctr, Geotech & Struct Lab, Vicksburg, MS 39180 USA.
EM henry.diaz-Alvarez@usace.army.mil
NR 10
TC 2
Z9 2
U1 1
U2 4
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 0892-7057
EI 1530-7980
J9 J THERMOPLAST COMPOS
JI J. Thermoplast. Compos. Mater.
PD APR
PY 2015
VL 28
IS 4
BP 461
EP 478
DI 10.1177/0892705713486127
PG 18
WC Materials Science, Composites
SC Materials Science
GA CE6KV
UT WOS:000351946200002
ER
PT J
AU Kheirabadi, BS
Valdez-Delgado, KK
Terrazas, LB
Miranda, N
Dubick, MA
AF Kheirabadi, Bijan S.
Valdez-Delgado, Krystal K.
Terrazas, Lrasema B.
Miranda, Nahir
Dubick, Michael A.
TI Is limited prehospital resuscitation with plasma more beneficial than
using a synthetic colloid? An experimental study in rabbits with
parenchymal bleeding
SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY
LA English
DT Article
DE Prehospital resuscitation; plasma; albumin; Hextend; uncontrolled
hemorrhage; rabbit
ID TRAUMATIC BRAIN-INJURY; FREEZE-DRIED PLASMA; BLOOD-TRANSFUSIONS
STRATEGIES; DAMAGE CONTROL RESUSCITATION; INTENSIVE-CARE-UNIT; LAST 60
YEARS; FLUID RESUSCITATION; DILUTIONAL COAGULOPATHY; INCREASING
HEMORRHAGE; ALBUMIN RESUSCITATION
AB BACKGROUND: Reports of survival benefits of early transfusion of plasma with red blood cells (1: 1 ratio) in trauma patients suggest that plasma may be a better fluid to replace Hextend for battlefield resuscitation. We studied possible advantages of prehospital resuscitation with plasma compared with Hextend or albumin in a model of uncontrolled hemorrhage.
METHODS: Male New Zealand white rabbits (3.3 +/- 0.1 kg) were anesthetized, instrumented, and subjected to a splenic injury with uncontrolled bleeding. Ten minutes after injury (mean arterial pressure [MAP] < 40 mm Hg), the rabbits received small and equal volumes (15 mL/kg) of rabbit plasma (n = 10), Hextend (n = 10), or 5% human albumin (n = 9) or no fluid. Fluids were administered in two bolus injections (20 minutes apart) and targeted to a MAP of 65 mm Hg. Animals were monitored for 2.5 hours or until death, and their blood losses were measured. Arterial blood samples were collected at different times and analyzed for ABG, CBC, and coagulation tests.
RESULTS: There were no differences in baseline measures among groups. Splenic injury caused similar hemorrhages (9.1 +/- 0.4 mL/kg at 10 minutes) and decreased MAP in all subjects. Subsequent resuscitation initiated additional bleeding. At 60 minutes after injury (20 minutes after resuscitation), longer activated partial thromboplastin time and lower fibrinogen concentrations were apparent compared with baseline values with differences among groups. Thrombelastography analysis indicated faster and stronger clot formation with plasma and albumin resuscitation than with Hextend use. Shock indices were increased in all groups, but smaller changes were measured in the albumin group. Total blood loss did not differ among resuscitated rabbits but was higher (p < 0.05) than among nonresuscitated animals. Survival rates were 11% (untreated), 40% (Hextend and plasma), and 89% (albumin, p < 0.05).
CONCLUSION: Resuscitation with plasma or albumin better preserved coagulation function than did Hextend. However, despite these improvements, plasma resuscitation did not reduce blood loss or improve survival, while albumin administration seemed beneficial. Copyright (C) 2015 Wolters Kluwer Health, Inc. All rights reserved.
C1 [Kheirabadi, Bijan S.; Valdez-Delgado, Krystal K.; Terrazas, Lrasema B.; Miranda, Nahir; Dubick, Michael A.] US Army Inst Surg Res, Jbsa Ft Sam Houston, TX USA.
RP Kheirabadi, BS (reprint author), 3650 Chambers Pass,BHT2,Bldg 3610, Ft Sam Houston, TX 78234 USA.
EM Bijan.s.kheirabadi.civ@mail.mil
FU US Army Medical Research and Materiel Command
FX The authors have no conflict of interest to report. The funding for this
work was provided the US Army Medical Research and Materiel Command.
NR 41
TC 4
Z9 4
U1 0
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 2163-0755
EI 2163-0763
J9 J TRAUMA ACUTE CARE
JI J. Trauma Acute Care Surg.
PD APR
PY 2015
VL 78
IS 4
BP 752
EP 759
DI 10.1097/TA.0000000000000591
PG 8
WC Critical Care Medicine; Surgery
SC General & Internal Medicine; Surgery
GA CE8EJ
UT WOS:000352074000014
PM 25807404
ER
PT J
AU Walker, MR
Babikian, S
Ernest, AJ
Koch, TS
Lustik, MB
Rooks, VJ
McMann, LP
AF Walker, Marc R.
Babikian, Sarkis
Ernest, Alexander J.
Koch, Troy S.
Lustik, Michael B.
Rooks, Veronica J.
McMann, Leah P.
TI Sonographic Evaluation of Hydronephrosis in the Pediatric Population Is
Well-Tempered Sonography Necessary?
SO JOURNAL OF ULTRASOUND IN MEDICINE
LA English
DT Article
DE anteroposterior diameter; hydration; pediatric ultrasound; prenatal
hydronephrosis; Society for Fetal Urology grade; sonography
ID URETEROPELVIC JUNCTION OBSTRUCTION; DIAGNOSTIC-ACCURACY; RENOGRAPHY;
DIURESIS; CHILDREN; VOLUME
AB Objectives-Standardized protocols exist for diuretic renography. There are no specific guidelines regarding hydration before renal sonography. This study assessed the importance of the hydration status by sonographic measurements of the anteroposterior diameter and its effect on Society for Fetal Urology (SFU) hydronephrosis grading.
Methods-Children aged 6 weeks to 16 years (mean age, 22 months) with unilateral SFU grade 3 or 4 hydronephrosis requiring diuretic renal scintigraphy were recruited to undergo prehydration and posthydration renal sonography. Hydrated diuretic renal scintigraphy, or "well-tempered" renography, was then performed. Renal sonograms were reviewed by a blinded pediatric radiologist and pediatric urologist. Two-sided statistical tests assessed whether SFU grades and the anteroposterior diameter changed significantly after hydration.
Results-Among 67 kidneys, the pediatric urologist (L.P.M.) and pediatric radiologist (V.J.R) reported no SFU grade change in 45 (67%) and 52(78%) kidneys after hydration. In kidneys that changed, the posthydration grade was more likely to be higher. This difference was statistically significant (14 of 22 and 13 of 15 differences were higher grades after hydration for L.P.M. and V.J.R., respectively; P=.06; P=.007). Most kidneys that changed-with hydration differed by only 1 SFU grade. Differences greater than 1 grade were seen in 5 control kidneys, which increased from SFU grade 0 to 2. The mean anteroposterior diameter increased significantly between prehydration and posthydration sonography for both hydronephrotic kidneys (1.46 versus 1.72 cm; P<.001) and control kidneys (0.22 versus 0.39 cm; P=.019), but did not correlate with increased SFU grades.
Conclusions-Hydration does have a substantial effect on the anteroposterior diameter, but it does not correlate with a substantial effect on the SFU grade; therefore, well-tempered sonography seems unnecessary.
C1 [Walker, Marc R.; Ernest, Alexander J.; McMann, Leah P.] Tripler Army Med Ctr, Dept Surg, Urol Serv, Honolulu, HI 96859 USA.
[Babikian, Sarkis; Koch, Troy S.; Rooks, Veronica J.] Tripler Army Med Ctr, Pediat Radiol Serv, Dept Radiol, Honolulu, HI 96859 USA.
[Lustik, Michael B.] Tripler Army Med Ctr, Dept Clin Invest, Honolulu, HI 96859 USA.
RP Walker, MR (reprint author), Tripler Army Med Ctr, Dept Surg, Urol Serv, 1 Jarrett White Rd, Honolulu, HI 96859 USA.
EM walkmr@gmail.com
NR 14
TC 1
Z9 2
U1 1
U2 2
PU AMER INST ULTRASOUND MEDICINE
PI LAUREL
PA SUBSCRIPTION DEPT, 14750 SWEITZER LANE, STE 100, LAUREL, MD 20707-5906
USA
SN 0278-4297
EI 1550-9613
J9 J ULTRAS MED
JI J. Ultrasound Med.
PD APR
PY 2015
VL 34
IS 4
BP 655
EP 662
DI 10.7863/ultra.34.4.655
PG 8
WC Acoustics; Radiology, Nuclear Medicine & Medical Imaging
SC Acoustics; Radiology, Nuclear Medicine & Medical Imaging
GA CE9RP
UT WOS:000352181400013
PM 25792581
ER
PT J
AU Matheny, RW
Riddle-Kottke, MA
Leandry, LA
Lynch, CM
Abdalla, MN
Geddis, AV
Piper, DR
Zhao, JJ
AF Matheny, Ronald W., Jr.
Riddle-Kottke, Melissa A.
Leandry, Luis A.
Lynch, Christine M.
Abdalla, Mary N.
Geddis, Alyssa V.
Piper, David R.
Zhao, Jean J.
TI Role of Phosphoinositide 3-OH Kinase p110 beta in Skeletal Myogenesis
SO MOLECULAR AND CELLULAR BIOLOGY
LA English
DT Article
ID MYOSIN HEAVY-CHAIN; PHOSPHATIDYLINOSITOL 3-KINASE; MUSCLE
DIFFERENTIATION; METABOLIC-REGULATION; P110-ALPHA ISOFORM;
GENE-TRANSCRIPTION; PI3K P110-ALPHA; SATELLITE CELLS; DRUG DISCOVERY;
GROWTH
AB Phosphoinositide 3-OH kinase (PI3K) regulates a number of developmental and physiologic processes in skeletal muscle; however, the contributions of individual PI3K p110 catalytic subunits to these processes are not well-defined. To address this question, we investigated the role of the 110-kDa PI3K catalytic subunit beta (p110 beta) in myogenesis and metabolism. In C2C12 cells, pharmacological inhibition of p110 beta delayed differentiation. We next generated mice with conditional deletion of p110 beta in skeletal muscle (p110 beta muscle knockout [ p110 beta-mKO] mice). While young p110 beta-mKO mice possessed a lower quadriceps mass and exhibited less strength than control littermates, no differences in muscle mass or strength were observed between genotypes in old mice. However, old p110 beta-mKO mice were less glucose tolerant than old control mice. Overexpression of p110 beta accelerated differentiation in C2C12 cells and primary human myoblasts through an Akt-dependent mechanism, while expression of kinase-inactive p110 beta had the opposite effect. p110 beta overexpression was unable to promote myoblast differentiation under conditions of p110 beta inhibition, but expression of p110 beta was able to promote differentiation under conditions of p110 beta inhibition. These findings reveal a role for p110 beta during myogenesis and demonstrate that long-term reduction of skeletal muscle p110 beta impairs whole-body glucose tolerance without affecting skeletal muscle size or strength in old mice.
C1 [Matheny, Ronald W., Jr.; Riddle-Kottke, Melissa A.; Leandry, Luis A.; Lynch, Christine M.; Abdalla, Mary N.; Geddis, Alyssa V.] US Army Res Inst Environm Med, Mil Performance Div, Natick, MA 01760 USA.
[Piper, David R.] Thermo Fisher Sci, Life Sci Solut, Biosci Div, Madison, WI USA.
[Zhao, Jean J.] Harvard Univ, Sch Med, Dana Farber Canc Inst, Dept Canc Biol, Boston, MA 02115 USA.
[Zhao, Jean J.] Harvard Univ, Sch Med, Dept Biol Chem & Mol Pharmacol, Boston, MA 02115 USA.
RP Matheny, RW (reprint author), US Army Res Inst Environm Med, Mil Performance Div, Natick, MA 01760 USA.
EM ronald.w.matheny.civ@mail.mil
FU Research Area Directorate III; Medical Research and Materiel Command;
NIH [R01 CA172461-02, U24-DK092993]; U.S. Army Research Institute of
Environmental Medicine
FX This work was supported by funding from Research Area Directorate III,
Medical Research and Materiel Command (to R.W.M.), and by NIH grants R01
CA172461-02 (to J.J.Z.) and U24-DK092993 (University of California,
Davis, Mouse Metabolic Phenotyping Center). C.M.L., A.V.G., and M.N.A.
were supported by appointments to the Postgraduate Research
Participation Program at the U.S. Army Research Institute of
Environmental Medicine, administered by the Oak Ridge Institute for
Science and Education through an interagency agreement between the U.S.
Department of Energy and the U.S. Army Medical Research and Materiel
Command.
NR 59
TC 6
Z9 6
U1 0
U2 6
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0270-7306
EI 1098-5549
J9 MOL CELL BIOL
JI Mol. Cell. Biol.
PD APR
PY 2015
VL 35
IS 7
BP 1182
EP 1196
DI 10.1128/MCB.00550-14
PG 15
WC Biochemistry & Molecular Biology; Cell Biology
SC Biochemistry & Molecular Biology; Cell Biology
GA CE3PG
UT WOS:000351739200009
PM 25605332
ER
PT J
AU Tritsch, AM
Bland, CM
Hatzigeorgiou, C
Sweeney, LB
Phillips, M
AF Tritsch, Adam M.
Bland, Christopher M.
Hatzigeorgiou, Christos
Sweeney, Lori B.
Phillips, Michael
TI A Retrospective Review of the Medical Management of Hypertension and
Diabetes Mellitus Following Sleeve Gastrectomy
SO OBESITY SURGERY
LA English
DT Article
DE Sleeve gastrectomy; Hypertension; Diabetes mellitus; Obesity; Medical
management
ID GASTRIC BYPASS; TYPE-2; SURGERY
AB Bariatric surgery is being performed with increasing frequency in the USA as a definitive treatment for morbid obesity and associated comorbidities. Management strategies of type 2 diabetes mellitus (T2DM) and hypertension (HTN) medications in sleeve gastrectomy (SG) patients postoperatively are unclear, specifically in the immediate postoperative period and 6 months following surgery.
From 01 June 2010 to 30 June 2011, at a single military medical facility, a retrospective review of 88 consecutive SG patients was conducted to examine the postoperative medical management of HTN and T2DM. Patient's HTN and T2DM medication regimens were evaluated for 6 months postoperatively. Categorical data was analyzed using chi-square, and continuous data was compared using the Student t test. Statistical analyses were completed with Stata, version 12.
Fifty patients were prescribed an average of 2.21 HTN medications at baseline which was reduced to an average of 1.23 (p < 0.01) medications per patient at 1 month. Twenty-four patients received an average of 1.41 oral T2DM medications with a reduction to 0.70 (p < 0.01) on average at 1 month postoperatively. Medication changes persisted throughout the 6-month follow-up. Among T2DM patients requiring insulin therapy, the mean insulin dose was 42.1 units reduced to 16.8 units immediately postoperatively (p < 0.01) which persisted at 1 month. At 6 months, the mean insulin dose was 13.3 units.
Medication adjustments for HTN and T2DM made immediately in the postoperative period following SG persisted throughout the 6-month follow-up period and in some patients, required further adjustments.
C1 [Tritsch, Adam M.; Bland, Christopher M.; Hatzigeorgiou, Christos; Sweeney, Lori B.; Phillips, Michael] Eisenhower Army Med Ctr, Ft Gordon, GA 30905 USA.
RP Tritsch, AM (reprint author), Eisenhower Army Med Ctr, 300 Hosp Rd, Ft Gordon, GA 30905 USA.
EM adam.m.tritsch.mil@mail.mil; chris.bland@us.army.mil;
Christos.hatzigeorgiou.mil@mail.mil; slowdiabetes@gmail.com;
michael.d.phillips182.mil@mail.mil
NR 11
TC 4
Z9 5
U1 1
U2 37
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0960-8923
EI 1708-0428
J9 OBES SURG
JI Obes. Surg.
PD APR
PY 2015
VL 25
IS 4
BP 642
EP 647
DI 10.1007/s11695-014-1375-y
PG 6
WC Surgery
SC Surgery
GA CE4AD
UT WOS:000351771500007
PM 25656260
ER
PT J
AU Kragh, JF
Dubick, MA
Aden, JK
McKeague, AL
Rasmussen, TE
Baer, DG
Blackbourne, LH
AF Kragh, John F., Jr.
Dubick, Michael A.
Aden, James K.
McKeague, Anne L.
Rasmussen, Todd E.
Baer, David G.
Blackbourne, Lorne H.
TI US MILITARY USE OF TOURNIQUETS FROM 2001 TO 2010
SO PREHOSPITAL EMERGENCY CARE
LA English
DT Article
DE emergency medical services; resuscitation; shock; first aid; medical
device
ID MAJOR LIMB TRAUMA; WAR
AB Objective. This study was conducted to associate tourniquet use and survival in casualty care over a decade of war in order to provide evidence to emergency medical personnel for the implementation and efficacy of tourniquet use in a large trauma system. Methods. This survey is a retrospective review of data extracted from a trauma registry. The decade (2001-2010) outcome trend analysis of tourniquet use in the current wars was made in order to associate tourniquet use and survival in an observational cohort design. Results. Of 4,297 casualties with extremity trauma in the total study, 30% (1,272/4,297) had tourniquet use and 70% (3,025/4,297) did not. For all 4,297 casualties, the proportion of casualties with severe or critical extremity Abbreviated Injury Scales (AIS) increased during the years surveyed (p < 0.0001); the mean annual Injury Severity Score (ISS) rose from 13 to 21. Tourniquet use increased during the decade by almost tenfold from 4 to nearly 40% (p < 0.0001). Survival for casualties with isolated extremity injury varied by injury severity; the survival rate for AIS 3 (serious) was 98%, the rate for AIS 4 (severe) was 76%, and the rate for AIS 5 (critical) was 0%. Survival rates increased for casualties with injuries amenable to tourniquets but decreased for extremity injuries too proximal for tourniquets. Conclusions. Average injury severity increased during the decade of war for casualties with extremity injury. Both tourniquet use rates and casualty survival rates rose when injuries were amenable to tourniquets.
C1 [Kragh, John F., Jr.; Aden, James K.; Baer, David G.] USAISR, Ft Sam Houston, TX 78234 USA.
[Kragh, John F., Jr.] Uniformed Serv Univ Hlth Sci, F Edward Hebert Sch Med, Bethesda, MD 20814 USA.
[Dubick, Michael A.] USAISR, ATTN MCMR USZ, Damage Control Resuscitat, Ft Sam Houston, TX 78234 USA.
RP Kragh, JF (reprint author), US Army, Inst Surg Res, Damage Control Resuscitat, 3650 Chambers Pass,Bldg BHT2 Room 222-4, Ft Sam Houston, TX 78234 USA.
EM john.f.kragh.civ@mail.mil; michael.a.dubick.civ@mail.mil;
James.k.aden2.civ@mail.mil; todd.e.rasmussen.mil@mail.mil;
david.g.baer.civ@mail.mil; lorne.h.blackbourne.mil@mail.mil
FU USAISR funds; Defense Health Program [201105]
FX This project was funded with internal USAISR funds, and the Defense
Health Program (Proposal 201105: Operational system management and
post-market surveillance of hemorrhage control devices used in medical
care of U.S. servicepersons in the current war).
NR 9
TC 6
Z9 6
U1 0
U2 1
PU INFORMA HEALTHCARE
PI LONDON
PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND
SN 1090-3127
EI 1545-0066
J9 PREHOSP EMERG CARE
JI Prehosp. Emerg. Care
PD APR-JUN
PY 2015
VL 19
IS 2
BP 184
EP 190
DI 10.3109/10903127.2014.964892
PG 7
WC Emergency Medicine; Public, Environmental & Occupational Health
SC Emergency Medicine; Public, Environmental & Occupational Health
GA CE6LS
UT WOS:000351948500002
PM 25420089
ER
PT J
AU Clinton, TR
Weinstock, MT
Jacobsen, MT
Szabo-Fresnais, N
Pandya, MJ
Whitby, FG
Herbert, AS
Prugar, LI
McKinnon, R
Hill, CP
Welch, BD
Dye, JM
Eckert, DM
Kay, MS
AF Clinton, Tracy R.
Weinstock, Matthew T.
Jacobsen, Michael T.
Szabo-Fresnais, Nicolas
Pandya, Maya J.
Whitby, Frank G.
Herbert, Andrew S.
Prugar, Laura I.
McKinnon, Rena
Hill, Christopher P.
Welch, Brett D.
Dye, John M.
Eckert, Debra M.
Kay, Michael S.
TI Design and characterization of ebolavirus GP prehairpin intermediate
mimics as drug targets
SO PROTEIN SCIENCE
LA English
DT Article
DE ebolavirus; filovirus entry; ebolavirus GP2; prehairpin intermediate;
designed coiled coil; N-trimer; phage display; mirror-image phage
display
ID IMMUNODEFICIENCY-VIRUS TYPE-1; D-PEPTIDE INHIBITORS; HUMAN
MONOCLONAL-ANTIBODY; VIRAL MEMBRANE-FUSION; NIEMANN-PICK C1; HIV-1 GP41;
ENVELOPE GLYCOPROTEIN; COILED-COIL; POSTEXPOSURE PROTECTION;
NONHUMAN-PRIMATES
AB Ebolaviruses are highly lethal filoviruses that cause hemorrhagic fever in humans and nonhuman primates. With no approved treatments or preventatives, the development of an anti-ebolavirus therapy to protect against natural infections and potential weaponization is an urgent global health need. Here, we describe the design, biophysical characterization, and validation of peptide mimics of the ebolavirus N-trimer, a highly conserved region of the GP2 fusion protein, to be used as targets to develop broad-spectrum inhibitors of ebolavirus entry. The N-trimer region of GP2 is 90% identical across all ebolavirus species and forms a critical part of the prehairpin intermediate that is exposed during viral entry. Specifically, we fused designed coiled coils to the N-trimer to present it as a soluble trimeric coiled coil as it appears during membrane fusion. Circular dichroism, sedimentation equilibrium, and X-ray crystallography analyses reveal the helical, trimeric structure of the designed N-trimer mimic targets. Surface plasmon resonance studies validate that the N-trimer mimic binds its native ligand, the C-peptide region of GP2. The longest N-trimer mimic also inhibits virus entry, thereby confirming binding of the C-peptide region during viral entry and the presence of a vulnerable prehairpin intermediate. Using phage display as a model system, we validate the suitability of the N-trimer mimics as drug screening targets. Finally, we describe the foundational work to use the N-trimer mimics as targets in mirror-image phage display, which will be used to identify D-peptide inhibitors of ebolavirus entry.
PDB Code(s):
C1 [Clinton, Tracy R.; Weinstock, Matthew T.; Jacobsen, Michael T.; Szabo-Fresnais, Nicolas; Pandya, Maya J.; Whitby, Frank G.; Hill, Christopher P.; Eckert, Debra M.; Kay, Michael S.] Univ Utah, Sch Med, Dept Biochem, Salt Lake City, UT 84112 USA.
[Szabo-Fresnais, Nicolas] Univ Utah, Sch Med, Dept Internal Med, Cardiol Sect, Salt Lake City, UT 84112 USA.
[Herbert, Andrew S.; Prugar, Laura I.; Dye, John M.] US Army, Med Res Inst Infect Dis, Frederick, MD 21702 USA.
[McKinnon, Rena; Welch, Brett D.] Navigen Inc, D Peptide Res Div, Salt Lake City, UT 84108 USA.
RP Eckert, DM (reprint author), Univ Utah, Sch Med, Dept Biochem, 15 N Med Dr East,Rm 4100, Salt Lake City, UT 84112 USA.
EM deckert@biochem.utah.edu; kay@biochem.utah.edu
FU University of Utah; NIH [AI102347, GM82545]; U.S. Air Force; U.S.
Department of Energy, Office of Science, Office of Basic Energy
Sciences; DOE Office of Biological and Environmental Research; NIH,
NIGMS
FX We thank Hyung Kim and Dennis Winge for amino acid analysis. We also
thank Yu-Chan Chen, Andrew Steiner, Ruei-Lin Hsu, and Niladri Sinha for
help with molecular biology, protein purification, and preliminary
characterization of the N-trimer mimics and C-peptides. For help with
peptide synthesis and purification, we thank Maritza Quintero and Dasha
Pruss, and we thank Matthew Movsesian for assistance and advice. This
research was funded by a University of Utah Funding Incentive Seed grant
to D.M.E. and M.S.K., NIH grant AI102347 to B.D.W. and M.S.K, and NIH
grant GM82545 to D.M.E. and C.P.H.. We thank the U.S. Air Force for
support of T.R.C.. Portions of this research were carried out at the
Stanford Synchrotron Radiation Light Source, (SSRL), which is supported
by the U.S. Department of Energy, Office of Science, Office of Basic
Energy Sciences. The SSRL Structural Molecular Biology Program is
supported by the DOE Office of Biological and Environmental Research,
and by the NIH, NIGMS. Opinions, conclusions, interpretations, and
recommendations are those of the authors and are not necessarily
endorsed by the U.S. Army, U.S. Air Force, the NIH or NIGMS. The mention
of trade names or commercial products does not constitute endorsement or
recommendation for use by the Department of the Army, the Department of
Defense, or the U.S. Air Force.
NR 76
TC 8
Z9 8
U1 2
U2 19
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0961-8368
EI 1469-896X
J9 PROTEIN SCI
JI Protein Sci.
PD APR
PY 2015
VL 24
IS 4
BP 446
EP 463
DI 10.1002/pro.2578
PG 18
WC Biochemistry & Molecular Biology
SC Biochemistry & Molecular Biology
GA CE5KR
UT WOS:000351873400003
PM 25287718
ER
PT J
AU Henein, NA
Ma, Z
Huang, SQ
Bryzik, W
Glidewell, J
AF Henein, Naeim A.
Ma, Zheng
Huang, Shengqiang
Bryzik, Walter
Glidewell, John
TI In Situ Wear Measuring Technique in Engine Cylinders
SO TRIBOLOGY & LUBRICATION TECHNOLOGY
LA English
DT Article
DE Automotive Tribology; Internal Combustion Engines, Gas; Wear and
Failure; Surface Roughness
ID RING WEAR; LINERS; BORES
AB An in situ wear probe was developed to measure the rate of cylinder liner wear and its roughness at the top ring reversal point where severe wear can occur The wear probe can be removed from the cylinder block and replaced without the need for engine disassembly The wear probe is scanned at a laser stylus surface measuring station where its topography and wear are analyzed. The engine used is a single-cylinder, air-cooled gasoline engine. A sample of the surface properties and analysis is given. Experimental data are given for the wear rate and different roughness parameters and their variation over the first few hours of the break-in period.
C1 [Henein, Naeim A.; Ma, Zheng] Wayne State Univ, Detroit, MI 48202 USA.
[Huang, Shengqiang] Caterpillar Inc, Peoria, IL 61629 USA.
[Bryzik, Walter] US Army TARDEC, Warren, MI USA.
[Glidewell, John] Ford Motor Co, Dearborn, MI 48121 USA.
RP Henein, NA (reprint author), Wayne State Univ, Detroit, MI 48202 USA.
FU U.S. Army National Automotive Center; TARDEC, Warren, MI
FX The sponsorship, technical and financial support of U.S. Army National
Automotive Center and TARDEC, Warren, MI, are acknowledged.
NR 17
TC 0
Z9 0
U1 1
U2 5
PU SOC TRIBOLOGISTS & LUBRICATION ENGINEERS
PI PARK RIDGE
PA 840 BUSSE HIGHWAY, PARK RIDGE, IL 60068 USA
SN 1545-858X
J9 TRIBOL LUBR TECHNOL
JI Tribol. Lubr. Technol.
PD APR
PY 2015
VL 71
IS 4
BP 46
EP 53
PG 8
WC Engineering, Mechanical
SC Engineering
GA CE4DD
UT WOS:000351780100012
ER
PT J
AU Leelawiwat, W
Rutvisuttinunt, W
Arroyo, M
Mueanpai, F
Kongpechsatit, O
Chonwattana, W
Chaikummao, S
de Souza, M
vanGriensven, F
McNicholl, JM
Curlin, ME
AF Leelawiwat, Wanna
Rutvisuttinunt, Wiriya
Arroyo, Miguel
Mueanpai, Famui
Kongpechsatit, Oranuch
Chonwattana, Wannee
Chaikummao, Supaporn
de Souza, Mark
vanGriensven, Frits
McNicholl, Janet M.
Curlin, Marcel E.
TI Increasing HIV-1 Molecular Complexity Among Men Who Have Sex with Men in
Bangkok
SO AIDS RESEARCH AND HUMAN RETROVIRUSES
LA English
DT Article
ID INJECTING DRUG-USERS; CIRCULATING RECOMBINANT FORM; TYPE-1 SUBTYPE E;
NEUTRALIZING ANTIBODIES; NORTHERN THAILAND; GENETIC DIVERSITY;
INFECTION; EPIDEMIOLOGY; CHINA; MSM
AB In Thailand, new HIV-1 infections are largely concentrated in certain risk groups such as men who have sex with men (MSM), where annual incidence may be as high as 12% per year. The paucity of information on the molecular epidemiology of HIV-1 in Thai MSM limits progress in understanding the epidemic and developing new prevention methods. We evaluated HIV-1 subtypes in seroincident and seroprevalent HIV-1-infected men enrolled in the Bangkok MSM Cohort Study (BMCS) between 2006 and 2011. We characterized HIV-1 subtype in 231 seroprevalent and 194 seroincident subjects using the multihybridization assay (MHA). Apparent dual infections, recombinant strains, and isolates found to be nontypeable by MHA were further characterized by targeted genomic sequencing. Most subjects were infected with HIV-1 CRF01_AE (82%), followed by infections with recombinants (11%, primarily CRF01_AE/B recombinants), subtype B (5%), and dual infections (2%). More than 11 distinct chimeric patterns were observed among CRF01B_AE/B recombinants, most involving recombination within integrase. A significant increase in the proportion of nontypeable strains was observed among seroincident MSM between 2006 and 2011. CRF01_AE and subtype B were the most and least common infecting strains, respectively. The predominance of CRF01_AE among HIV-1 infections in Thai MSM participating in the BMCS parallels trends observed in Thai heterosexuals and injecting drug users. The presence of complex recombinants and a significant rise in nontypeable strains suggest ongoing changes in the genetic makeup of the HIV-1 epidemic in Thailand, which may pose challenges for HIV-1 prevention efforts and vaccine development.
C1 [Leelawiwat, Wanna; Mueanpai, Famui; Kongpechsatit, Oranuch; Chonwattana, Wannee; Chaikummao, Supaporn; vanGriensven, Frits; McNicholl, Janet M.; Curlin, Marcel E.] Thailand MOPH US CDC Collaborat, Nonthaburi 11000, Thailand.
[Rutvisuttinunt, Wiriya; Arroyo, Miguel] Armed Forces Res Inst Med Sci, Dept Retrovirol, Bangkok 10400, Thailand.
[de Souza, Mark] Thai Red Cross AIDS Res Ctr, SEARCH Thailand, Bangkok, Thailand.
[vanGriensven, Frits; McNicholl, Janet M.; Curlin, Marcel E.] Ctr Dis Control & Prevent, Div HIV AIDS Prevent, Atlanta, GA USA.
RP Leelawiwat, W (reprint author), Thailand MOPH US CDC Collaborat, DMSC Bldg 2,Tivanon Rd, Nonthaburi 11000, Thailand.
EM wannal@cdc.gov
OI Arroyo, Miguel/0000-0001-7416-8867
FU U.S. military HIV-1 Research; Henry M. Jackson Foundation
FX The authors would like to thank the participants in this study, and
acknowledge the support and funding from the U.S. military HIV-1
Research and the Henry M. Jackson Foundation. We also thank Viseth
Ngauy, Vatcharin Assawadarachai, Kultida Poltavee, Hathairat Savadsuk,
and Suwittra Chaemchuen of the Armed Forces Research Institute of
Medical Sciences, Thailand for their support of this study; Sodsai
Tovanabutra, Gustavo Kijak, Eric Sander-Buell, Morgane Rolland, Francine
McCutcheon, and Jerome Kim of the U.S. Military HIV Research Program for
their technical and intellectual input; Jaray Tongtoyai, Atittaya
Sangiamkittikul, Punneeporn Wasinrapee, Natthaga Sakulploy, Kusuma
Auethavoranan, and Wanna Suwanaphan of the Thai MOPH US-CDC
Collaboration (TUC) laboratory for processing and testing all the
samples; Sarika Pattanasin, Boonyos Raengsakulrach, and Chonticha
Kittinunvorakoon for helpful advice; and the remaining members of our
collaborative study group.
NR 53
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U1 0
U2 0
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0889-2229
EI 1931-8405
J9 AIDS RES HUM RETROV
JI Aids Res. Hum. Retrovir.
PD APR 1
PY 2015
VL 31
IS 4
BP 393
EP 400
DI 10.1089/aid.2014.0139
PG 8
WC Immunology; Infectious Diseases; Virology
SC Immunology; Infectious Diseases; Virology
GA CE5JR
UT WOS:000351869400007
PM 25366819
ER
PT J
AU Harrison, SA
AF Harrison, Stephen A.
TI Nonalcoholic Fatty Liver Disease and Fibrosis Progression: The Good, the
Bad, and the Unknown
SO CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
LA English
DT Editorial Material
ID FOLLOW-UP; ASSOCIATION; DIAGNOSIS; RISK
C1 Brooke Army Med Ctr, Dept Med, Div Gastroenterol, Houston, TX 78234 USA.
RP Harrison, SA (reprint author), Brooke Army Med Ctr, Dept Med, Div Gastroenterol, Houston, TX 78234 USA.
NR 13
TC 2
Z9 2
U1 0
U2 1
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1542-3565
EI 1542-7714
J9 CLIN GASTROENTEROL H
JI Clin. Gastroenterol. Hepatol.
PD APR
PY 2015
VL 13
IS 4
BP 655
EP 657
DI 10.1016/j.cgh.2014.11.024
PG 3
WC Gastroenterology & Hepatology
SC Gastroenterology & Hepatology
GA CD7UL
UT WOS:000351299300010
PM 25478921
ER
PT J
AU Leon, LR
Bouchama, A
AF Leon, Lisa R.
Bouchama, Abderrezak
TI Heat Stroke
SO COMPREHENSIVE PHYSIOLOGY
LA English
DT Article
ID TUMOR-NECROSIS-FACTOR; WHOLE-BODY HYPERTHERMIA; DISSEMINATED
INTRAVASCULAR COAGULATION; ACUTE KIDNEY INJURY; PREOPTIC THERMOSENSITIVE
NEURONS; HUMAN THERMOREGULATORY RESPONSES; SYSTEMIC INFLAMMATORY
RESPONSE; MONOCYTE PROCOAGULANT ACTIVITY; MUSCLE SARCOPLASMIC-RETICULUM;
ACUTE MYOCARDIAL-INFARCTION
AB Heat stroke is a life-threatening condition clinically diagnosed as a severe elevation in body temperature with central nervous system dysfunction that often includes combativeness, delirium, seizures, and coma. Classic heat stroke primarily occurs in immunocompromised individuals during annual heat waves. Exertional heat stroke is observed in young fit individuals performing strenuous physical activity in hot or temperature environments. Long-term consequences of heat stroke are thought to be due to a systemic inflammatory response syndrome. This article provides a comprehensive review of recent advances in the identification of risk factors that predispose to heat stroke, the role of endotoxin and cytokines in mediation of multi-organ damage, the incidence of hypothermia and fever during heat stroke recovery, clinical biomarkers of organ damage severity, and protective cooling strategies. Risk factors include environmental factors, medications, drug use, compromised health status, and genetic conditions. The role of endotoxin and cytokines is discussed in the framework of research conducted over 30 years ago that requires reassessment to more clearly identify the role of these factors in the systemic inflammatory response syndrome. We challenge the notion that hypothalamic damage is responsible for thermoregulatory disturbances during heat stroke recovery and highlight recent advances in our understanding of the regulated nature of these responses. The need for more sensitive clinical biomarkers of organ damage is examined. Conventional and emerging cooling methods are discussed with reference to protection against peripheral organ damage and selective brain cooling. Published 2015.
C1 [Leon, Lisa R.] US Army Res Inst Environm Med, Natick, MA 01760 USA.
[Bouchama, Abderrezak] King Saud Bin Abdulaziz Univ Hlth Sci, King Abdullah Int Med Res Ctr, Dept Expt Med, King Abdulaziz Med City,Minist Natl Guard Hlth Af, Riyadh, Saudi Arabia.
RP Leon, LR (reprint author), US Army Res Inst Environm Med, Natick, MA 01760 USA.
EM lisa.r.leon.civ@mail.mil
NR 420
TC 13
Z9 17
U1 6
U2 31
PU JOHN WILEY & SONS INC
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN, NJ 07030 USA
SN 2040-4603
J9 COMPR PHYSIOL
JI Compr. Physiol.
PD APR
PY 2015
VL 5
IS 2
BP 611
EP 647
DI 10.1002/cphy.c140017
PG 37
WC Physiology
SC Physiology
GA CE0JT
UT WOS:000351491000006
PM 25880507
ER
PT J
AU Cho, JH
AF Cho, Jin-Hee
TI Tradeoffs between Trust and Survivability for Mission Effectiveness in
Tactical Networks
SO IEEE TRANSACTIONS ON CYBERNETICS
LA English
DT Article
DE Group trust; mean time to mission failure (MTTMF); mission
effectiveness; survivability; tactical network; trust; trust threshold
ID ASPIRATION; LEVEL; COMMUNICATION; MANAGEMENT; COLLUSION
AB In a military tactical network, maintaining trust among members in a mission group is critical to successful mission completion. However, maintaining high trust among group members in a resource-restricted tactical environment detrimentally reduces system lifetime, which may lead to mission failure or low mission effectiveness. In this paper, we aim to investigate the relationships between group trust and system lifetime [i.e., survivability measuring mean time to mission failure (MTTMF)] and to capture mission effectiveness achieved by the mission group based on the tradeoff between these two goals. We employ a composite trust capturing various angles of trust concept derived from communication, information, and social networks. We take a game theoretic approach using the so called Aoyagi's game theory, enforcing nodes to exhibit desirable behavior based on reward or penalty given by the system. In designing reward/penalty mechanisms, we adopt the concept of aspiration level, defining success or failure based on a goal set by the system, and prove there exists an optimal trust threshold maximizing both MTTMF(i.e., system lifetime/survivability) and group trust. We devised a mission effectiveness metric based on both the metrics having conflicting goals. We developed an analytical model using Stochastic Petri Nets, and validated the analytical results with simulation results. We conducted comparative performance analysis of the variations of the proposed scheme with respect to a node's decision nature (i.e., rational versus altruistic) and trust threshold policy (static versus dynamic) in resource-constrained tactical environments.
C1 US Army Res Lab, Computat & Informat Sci Directorate, Adelphi, MD 20783 USA.
RP Cho, JH (reprint author), US Army Res Lab, Computat & Informat Sci Directorate, Adelphi, MD 20783 USA.
EM jinhee.cho@us.army.mil
FU Department of Defense (DoD) through office of the Assistant Secretary of
Defense for Research and Engineering (ASD R E)
FX This work was supported by the Department of Defense (DoD) through the
office of the Assistant Secretary of Defense for Research and
Engineering (ASD R& E). The views and opinions of the author(s) do not
reflect those of the DoD or ASD R& E. This paper was recommended by
Associate Editor J. Liu.
NR 34
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Z9 1
U1 1
U2 7
PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
PI PISCATAWAY
PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA
SN 2168-2267
EI 2168-2275
J9 IEEE T CYBERNETICS
JI IEEE T. Cybern.
PD APR
PY 2015
VL 45
IS 4
BP 754
EP 766
DI 10.1109/TCYB.2014.2335744
PG 13
WC Computer Science, Artificial Intelligence; Computer Science, Cybernetics
SC Computer Science
GA CE0BL
UT WOS:000351467400013
PM 25069134
ER
PT J
AU Cloutier, R
Sauser, B
Bone, M
Taylor, A
AF Cloutier, Robert
Sauser, Brian
Bone, Mary
Taylor, Andrew
TI Transitioning Systems Thinking to Model-Based Systems Engineering:
Systemigrams to SysML Models
SO IEEE TRANSACTIONS ON SYSTEMS MAN CYBERNETICS-SYSTEMS
LA English
DT Article
DE Model-based systems engineering (MBSE); SysML; systemigram; systems
thinking
ID MANAGEMENT
AB A fundamental challenge for system engineers is to capture a problem with an effective model or framework and then facilitate transferring the information of that captured problem to practical systems engineering tools and methods. The early problem definition phase requires an application of systems thinking with adequate modeling tools and methods. Then, the later problem definition phase and early system architecting phase requires transferring the captured problem to systems engineering tools and methods through emerging techniques such as model-based systems engineering (MBSE) using SysML (MBSE is the practice of using a modeling tools to capture systems engineering diagrams). This paper presents a method for capturing a problem through systemigrams and the Boardman soft systems methodology and then directly translating the systemigrams into SysML diagrams. With MBSE increasing in usage, this method could provide a time savings opportunity during model development along with the possibility of lowering information distortion or loss that can occur during transformation of systems thinking to systems engineering activities. This paper includes a case study which demonstrates how the proposed approach was applied on a problem being considered by the U.S. Army-Contingency Basing for Small Combat Units. Finally, this paper will provide the conclusion on the development of the method and describe future research directions that can allow systems thinking and MBSE to function in a congruent methodology.
C1 [Cloutier, Robert; Bone, Mary] Stevens Inst Technol, Hoboken, NJ 07030 USA.
[Sauser, Brian] Univ N Texas, Denton, TX 76203 USA.
[Taylor, Andrew] US Army Natick Soldier Res, Ctr Dev & Engn, Natick, MA 01760 USA.
RP Sauser, B (reprint author), Univ N Texas, Denton, TX 76203 USA.
EM brian.sauser@unt.edu
FU Systems Engineering Research Center (SERC); University Affiliated
Research Center
FX This work was supported by the Systems Engineering Research Center
(SERC). SERC is a federally funded University Affiliated Research Center
managed by the Stevens Institute of Technology. This paper was
recommended by Associate Editor K. W. Hipel.
NR 41
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Z9 0
U1 5
U2 23
PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
PI PISCATAWAY
PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA
SN 2168-2216
J9 IEEE T SYST MAN CY-S
JI IEEE Trans. Syst. Man Cybern. -Syst.
PD APR
PY 2015
VL 45
IS 4
BP 662
EP 674
DI 10.1109/TSMC.2014.2379657
PG 13
WC Automation & Control Systems; Computer Science, Cybernetics
SC Automation & Control Systems; Computer Science
GA CE1BH
UT WOS:000351545900010
ER
PT J
AU Crowell, TA
Berry, SA
Fleishman, JA
LaRue, RW
Korthuis, PT
Nijhawan, AE
Moore, RD
Gebo, KA
AF Crowell, Trevor A.
Berry, Stephen A.
Fleishman, John A.
LaRue, Richard W.
Korthuis, Philip T.
Nijhawan, Ank E.
Moore, Richard D.
Gebo, Kelly A.
CA HIV Res Network
TI Impact of Hepatitis Coinfection on Healthcare Utilization Among Persons
Living With HIV
SO JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES
LA English
DT Article
DE HIV; hepatitis B virus; hepatitis C virus; mental health; healthcare
utilization; hospitalization
ID C VIRUS-INFECTION; ACTIVE ANTIRETROVIRAL THERAPY; UNITED-STATES;
HEPATOCELLULAR-CARCINOMA; HOSPITALIZATION RATES; MULTICENTER COHORT;
VIRAL-HEPATITIS; NATURAL-HISTORY; HCV INFECTION; MORTALITY
AB Hepatitis B virus (HBV) and hepatitis C virus (HCV) coinfection are increasingly important sources of morbidity among HIV-infected persons. We determined associations between hepatitis coinfection and healthcare utilization among HIV-infected adults at 4 US sites during 2006-2011. Outpatient HIV visits did not differ by hepatitis serostatus and decreased over time. Mental health visits were more common among HIV/HCV coinfected persons than among HIV monoinfected persons [incidence rate ratio (IRR): 1.27, 95% confidence interval (CI): 1.08 to 1.50]. Hospitalization rates were higher among all hepatitis-infected groups than among HIV monoinfected (HIV/HBV: IRR: 1.23, 95% CI: 1.05 to 1.44; HIV/HCV: IRR: 1.22, 95% CI: 1.10 to 1.36; HIV/HBV/HCV: IRR: 1.31, 95% CI: 1.02 to 1.68). These findings may inform the design of clinical services and allocation of resources.
C1 [Crowell, Trevor A.; Berry, Stephen A.; LaRue, Richard W.; Moore, Richard D.; Gebo, Kelly A.] Johns Hopkins Univ, Sch Med, Dept Med, Div Infect Dis, Baltimore, MD 21205 USA.
[Fleishman, John A.] Agcy Healthcare Res & Qual, Ctr Financing Access & Cost Trends, Rockville, MD USA.
[Korthuis, Philip T.] Oregon Hlth & Sci Univ, Dept Med, Div Gen Internal Med & Geriatr, Portland, OR 97201 USA.
[Nijhawan, Ank E.] Univ Texas SW Med Ctr Dallas, Dept Internal Med, Div Infect Dis, Dallas, TX 75390 USA.
RP Crowell, TA (reprint author), Walter Reed Army Inst Res, US Mil HIV Res Program, 6720-A Rockledge Dr,Suite 400, Bethesda, MD 20817 USA.
EM tcrowell@hivresearch.org
FU Agency for Healthcare Research and Quality [HHSA290201100007C]; Health
Resources and Services Administration [HHSH250201200008C]; National
Institute of Allergy and Infectious Diseases [K23 AI084854]; National
Center for Advancing Translational Sciences [KL2TR001103]; Tibotec
FX Supported by the Agency for Healthcare Research and Quality
(HHSA290201100007C), the Health Resources and Services Administration
(HHSH250201200008C), the National Institute of Allergy and Infectious
Diseases (K23 AI084854), and the National Center for Advancing
Translational Sciences (KL2TR001103).; K.A.G. has been a consultant to
Tibotec and BMS and received research funding from Tibotec. The
remaining authors have no conflicts of interest to disclose.
NR 37
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U1 0
U2 4
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1525-4135
EI 1077-9450
J9 JAIDS-J ACQ IMM DEF
JI JAIDS
PD APR 1
PY 2015
VL 68
IS 4
BP 425
EP 431
PG 7
WC Immunology; Infectious Diseases
SC Immunology; Infectious Diseases
GA CE1RC
UT WOS:000351588600014
PM 25559601
ER
PT J
AU Ananworanich, J
Sirivichayakul, S
Pinyakorn, S
Crowell, TA
Trichavaroj, R
Weerayingyong, J
Chomchey, N
Fletcher, JLK
van Griensven, F
Phanuphak, P
Robb, ML
Michael, NL
Kim, JH
Phanuphak, N
AF Ananworanich, Jintanat
Sirivichayakul, Sunee
Pinyakorn, Suteeraporn
Crowell, Trevor A.
Trichavaroj, Rapee
Weerayingyong, Jessica
Chomchey, Nitiya
Fletcher, James L. K.
van Griensven, Frits
Phanuphak, Praphan
Robb, Merlin L.
Michael, Nelson L.
Kim, Jerome H.
Phanuphak, Nittaya
CA SEARCH RV 254 Study Grp
TI High Prevalence of Transmitted Drug Resistance in Acute HIV-Infected
Thai Men Who Have Sex With Men
SO JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES
LA English
DT Article
DE transmitted drug resistance; acute HIV; Thailand; men who have sex with
men
ID RESOURCE-LIMITED SETTINGS; ANTIRETROVIRAL THERAPY;
REVERSE-TRANSCRIPTASE; NAIVE INDIVIDUALS; SCALING-UP; MUTATIONS;
SURVEILLANCE; MULTICENTER; EPIDEMIC; BANGKOK
AB As use of antiretroviral therapy in Thailand increases, so does the potential for transmission of drug-resistant HIV. We describe the prevalence of WHO surveillance drug resistance mutations among 120 subjects who underwent genotypic testing during acute HIV infection in Bangkok, Thailand. In this cohort of predominantly men who have sex with men, we observed an overall transmitted drug resistance prevalence of 9.2%, including nucleoside/nucleotide analog reverse transcriptase inhibitor 5.0%, nonnucleoside analog reverse transcriptase inhibitor 3.4%, and protease inhibitor 3.4%. These prevalence estimates are higher than previous reports of transmitted drug resistance in Thailand. Baseline drug resistance testing may be warranted, particularly among men who have sex with men.
C1 [Ananworanich, Jintanat; Crowell, Trevor A.; Robb, Merlin L.; Michael, Nelson L.; Kim, Jerome H.] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD USA.
[Ananworanich, Jintanat; Crowell, Trevor A.; Robb, Merlin L.] Henry M Jackson Fdn Adv Mil Med, Bethesda, MD USA.
[Ananworanich, Jintanat; Pinyakorn, Suteeraporn; Weerayingyong, Jessica; Chomchey, Nitiya; Fletcher, James L. K.; Phanuphak, Praphan; Kim, Jerome H.; Phanuphak, Nittaya] SEARCH Thailand, Bangkok, Thailand.
[Sirivichayakul, Sunee; Pinyakorn, Suteeraporn; Chomchey, Nitiya; Fletcher, James L. K.; van Griensven, Frits; Phanuphak, Praphan; Phanuphak, Nittaya] Thai Red Cross AIDS Res Ctr, Bangkok, Thailand.
[Sirivichayakul, Sunee] Chulalongkorn Univ, Fac Med, Dept Med, Bangkok 10330, Thailand.
[Trichavaroj, Rapee] Armed Forces Res Inst Med Sci, US Component, Dept Retrovirol, Bangkok 10400, Thailand.
RP Ananworanich, J (reprint author), Walter Reed Army Inst Res, US Mil HIV Res Program, 6720A Rockledge Dr,Suite 400, Bethesda, MD 20817 USA.
EM jananworanich@hivresearch.org
FU Henry M. Jackson Foundation for the Advancement of Military Medicine,
Inc [W81XWH-07-2-0067, W81XWH-11-2-0174]; US Department of the Army
[W81XWH-07-2-0067, W81XWH-11-2-0174]; Thai Red Cross AIDS Research
Center
FX Supported by cooperative agreements (W81XWH-07-2-0067 and
W81XWH-11-2-0174) between The Henry M. Jackson Foundation for the
Advancement of Military Medicine, Inc, and the US Department of the Army
and by an intramural grant from the Thai Red Cross AIDS Research Center.
The US Army Medical Research Acquisition Activity, 820 Chandler Street,
Fort Detrick, MD 21702-5014, is the awarding and administering
acquisition office for the cooperative agreement. Antiretroviral therapy
was supported by the Thai Government Pharmaceutical Organization,
Gilead, Merck, and Pfizer.
NR 38
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Z9 4
U1 0
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1525-4135
EI 1077-9450
J9 JAIDS-J ACQ IMM DEF
JI JAIDS
PD APR 1
PY 2015
VL 68
IS 4
BP 481
EP 485
PG 5
WC Immunology; Infectious Diseases
SC Immunology; Infectious Diseases
GA CE1RC
UT WOS:000351588600022
PM 25559593
ER
PT J
AU Burns, JW
Quartana, PJ
Bruehl, S
Janssen, I
Dugan, SA
Appelhans, B
Matthews, KA
Kravitz, HM
AF Burns, John W.
Quartana, Phillip J.
Bruehl, Stephen
Janssen, Imke
Dugan, Sheila A.
Appelhans, Bradley
Matthews, Karen A.
Kravitz, Howard M.
TI Chronic pain, body mass index and cardiovascular disease risk factors:
tests of moderation, unique and shared relationships in the Study of
Women's Health Across the Nation (SWAN)
SO JOURNAL OF BEHAVIORAL MEDICINE
LA English
DT Article
DE Persistent pain; BMI; CVD risk factors; Moderation
ID RESTING BLOOD-PRESSURE; REPORTING CHRONIC PAIN; CHRONIC SPINAL PAIN;
GENERAL-POPULATION; MUSCULOSKELETAL PAIN; REGULATORY SYSTEMS; METABOLIC
SYNDROME; PHYSICAL-ACTIVITY; HEART-DISEASE; UNITED-STATES
AB Chronic pain may be related to cardiovascular disease (CVD) risk. The current study examined whether persistent bodily pain was related to cardiovascular disease risk factors, whether these effects were moderated by body mass index (BMI), and, if not, whether chronic pain accounted for unique variance in CVD risk factors. Participants were women (N = 2,135) in the Study of Women's Health Across the Nation. A high pain frequency variable (high pain in 0 through 4 assessments) was coded to reflect the frequency of high levels of bodily pain across the first 3 years of the study. Six CVD risk factors and BMI were measured at follow-up year 3. High pain frequency and BMI were correlated significantly with risk factors, although effects for the former were small. Hierarchical multiple regressions revealed high pain frequency x BMI interactions for 5 of 6 CVD risk factors. Dissecting the interactions revealed a similar pattern across 4 risk factors: for women with normal BMI, there was a "dose-response" in which increasing frequency of high pain revealed increasingly worse CVD risk factor levels, whereas for women with obese BMI, high pain frequency was unrelated to risk factors. For obese women, increasing frequency of high pain was associated with higher blood glucose. Although BMI is a well-established CVD risk factor, evaluation of CVD risk level may be improved by considering the incidence of persistent pain, particularly in normal weight women (BMI < 25 kg/m(2)) lower BMI.
C1 [Burns, John W.; Janssen, Imke; Dugan, Sheila A.; Appelhans, Bradley; Kravitz, Howard M.] Rush Univ, Dept Behav Sci, Med Ctr, Chicago, IL 60612 USA.
[Quartana, Phillip J.] Walter Reed Army Inst Res, Silver Spring, MD USA.
[Bruehl, Stephen] Vanderbilt Univ, Med Ctr, Nashville, TN USA.
[Matthews, Karen A.] Univ Pittsburgh, Sch Med, Pittsburgh, PA USA.
RP Burns, JW (reprint author), Rush Univ, Dept Behav Sci, Med Ctr, 1645 W Jackson Blvd, Chicago, IL 60612 USA.
EM John_burns@rush.edu
FU National Institutes of Health (NIH), DHHS, through the National
Institute on Aging (NIA); National Institute of Nursing Research (NINR);
NIH Office of Research on Women's Health (ORWH) [U01NR004061,
U01AG012505, U01AG012535, U01AG012531, U01AG012539, U01AG012546,
U01AG012553, U01AG012554, U01AG012495]
FX The data used in this study are derived from The Study of Women's Health
Across the Nation (SWAN). Grant support for SWAN is from the National
Institutes of Health (NIH), DHHS, through the National Institute on
Aging (NIA), the National Institute of Nursing Research (NINR) and the
NIH Office of Research on Women's Health (ORWH) (Grants U01NR004061;
U01AG012505, U01AG012535, U01AG012531, U01AG012539, U01AG012546,
U01AG012553, U01AG012554, U01AG012495). The content of this manuscript
is solely the responsibility of the authors and does not necessarily
represent the official views of the NIA, NINR, ORWH or the NIH. The
opinions or assertions contained herein are the private views of the
authors, and are not to be construed as official, or as reflecting true
views, of the Department of the Army or the Department of Defense.
NR 46
TC 3
Z9 3
U1 2
U2 3
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0160-7715
EI 1573-3521
J9 J BEHAV MED
JI J. Behav. Med.
PD APR
PY 2015
VL 38
IS 2
BP 372
EP 383
DI 10.1007/s10865-014-9608-z
PG 12
WC Psychology, Clinical
SC Psychology
GA CD5NV
UT WOS:000351135900018
PM 25427423
ER
PT J
AU Pal, S
Dauner, AL
Valks, A
Forshey, BM
Long, KC
Thaisomboonsuk, B
Sierra, G
Picos, V
Talmage, S
Morrison, AC
Halsey, ES
Comach, G
Yasuda, C
Loeffelholz, M
Jarman, RG
Fernandez, S
An, US
Kochel, TJ
Jasper, LE
Wu, SJL
AF Pal, Subhamoy
Dauner, Allison L.
Valks, Andrea
Forshey, Brett M.
Long, Kanya C.
Thaisomboonsuk, Butsaya
Sierra, Gloria
Picos, Victor
Talmage, Sara
Morrison, Amy C.
Halsey, Eric S.
Comach, Guillermo
Yasuda, Chadwick
Loeffelholz, Michael
Jarman, Richard G.
Fernandez, Stefan
An, Ung Sam
Kochel, Tadeusz J.
Jasper, Louis E.
Wu, Shuenn-Jue L.
TI Multicountry Prospective Clinical Evaluation of Two Enzyme-Linked
Immunosorbent Assays and Two Rapid Diagnostic Tests for Diagnosing
Dengue Fever
SO JOURNAL OF CLINICAL MICROBIOLOGY
LA English
DT Article
ID IMMUNOGLOBULIN-M; VIRUS-INFECTION; CAPTURE ELISA; IMMUNOCHROMATOGRAPHIC
TEST; CELL-CULTURES; NS1 ANTIGEN; ANTIBODY; ACCURACY; IDENTIFICATION;
SENSITIVITY
AB We evaluated four dengue diagnostic devices from Alere, including the SD Bioline Dengue Duo (nonstructural [NS] 1 Ag and IgG/IgM), the Panbio Dengue Duo Cassette (IgM/IgG) rapid diagnostic tests (RDTs), and the Panbio dengue IgM and IgG capture enzyme-linked immunosorbent assays (ELISAs) in a prospective, controlled, multicenter study in Peru, Venezuela, Cambodia, and the United States, using samples from 1,021 febrile individuals. Archived, well-characterized samples from an additional 135 febrile individuals from Thailand were also used. Reference testing was performed on all samples using an algorithm involving virus isolation, in-house IgM and IgG capture ELISAs, and plaque reduction neutralization tests (PRNT) to determine the infection status of the individual. The primary endpoints were the clinical sensitivities and specificities of these devices. The SD Bioline Dengue Duo had an overall sensitivity of 87.3% (95% confidence interval [CI], 84.1 to 90.2%) and specificity of 86.8% (95% CI, 83.9 to 89.3%) during the first 14 days post-symptom onset (p.s.o.). The Panbio Dengue Duo Cassette demonstrated a sensitivity of 92.1% (87.8 to 95.2%) and specificity of 62.2% (54.5 to 69.5%) during days 4 to 14 p.s.o. The Panbio IgM capture ELISA had a sensitivity of 87.6% (82.7 to 91.4%) and specificity of 88.1% (82.2 to 92.6%) during days 4 to 14 p.s.o. Finally, the Panbio IgG capture ELISA had a sensitivity of 69.6% (62.1 to 76.4%) and a specificity of 88.4% (82.6 to 92.8%) during days 4 to 14 p.s.o. for identification of secondary dengue infections. This multicountry prospective study resulted in reliable real-world performance data that will facilitate data-driven laboratory test choices for managing patient care during dengue outbreaks.
C1 [Pal, Subhamoy; Dauner, Allison L.; Kochel, Tadeusz J.; Wu, Shuenn-Jue L.] Naval Med Res Ctr, Silver Spring, MD 20910 USA.
[Valks, Andrea] Alere, Brisbane, Qld, Australia.
[Forshey, Brett M.; Long, Kanya C.; Morrison, Amy C.; Halsey, Eric S.] US Naval Med Res Unit 6, Lima, Peru.
[Sierra, Gloria; Picos, Victor; Comach, Guillermo] Univ Carabobo BIOMED UC, Lab Reg Diagnost & Invest Dengue & Otras Enfermed, Inst Invest Biomed, Maracay, Venezuela.
[Yasuda, Chadwick] US Naval Med Res Unit 2, Phnom Penh, Cambodia.
[Talmage, Sara; Loeffelholz, Michael] Univ Texas Med Branch, Galveston, TX 77555 USA.
[Long, Kanya C.; Morrison, Amy C.] Univ Calif Davis, Davis, CA 95616 USA.
[Jarman, Richard G.] Walter Reed Army Inst Res, Silver Spring, MD USA.
[Thaisomboonsuk, Butsaya; Fernandez, Stefan] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand.
[Jasper, Louis E.] US Army Med Mat Dev Act, Frederick, MD USA.
[An, Ung Sam] Natl Inst Publ Hlth, Phnom Penh, Cambodia.
RP Pal, S (reprint author), Naval Med Res Ctr, Silver Spring, MD 20910 USA.
EM subhamoy.pal.ctr@mail.mil
RI Pal, Subhamoy/A-9526-2015;
OI Pal, Subhamoy/0000-0003-0133-8444; Dauner, Allison/0000-0001-7346-7355
FU Military Infectious Diseases Research Program [L0091_07_NM,
L010011_09_NM, L0185_10_NM, L0186_10_NM, L0257_12_NM, L0262_12_NM];
[6000.RAD1.L.A1220]
FX This work was funded by the Military Infectious Diseases Research
Program, proposal numbers L0091_07_NM, L010011_09_NM, L0185_10_NM,
L0186_10_NM, L0257_12_NM, and L0262_12_NM. The work was supported by
Work Unit Number 6000.RAD1.L.A1220.
NR 58
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Z9 5
U1 0
U2 1
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0095-1137
EI 1098-660X
J9 J CLIN MICROBIOL
JI J. Clin. Microbiol.
PD APR
PY 2015
VL 53
IS 4
BP 1092
EP 1102
DI 10.1128/JCM.03042-14
PG 11
WC Microbiology
SC Microbiology
GA CD8QA
UT WOS:000351359500008
PM 25588659
ER
PT J
AU Milillo, M
Kwak, YI
Snesrud, E
Waterman, PE
Lesho, E
McGann, P
AF Milillo, Michael
Kwak, Yoon I.
Snesrud, Erik
Waterman, Paige E.
Lesho, Emil
McGann, Patrick
TI Correction for Milillo et al., Rapid and Simultaneous Detection of
bla(KPC) and bla(NDM) by Use of Multiplex Real-Time PCR (vol 51, pg
1247, 2013)
SO JOURNAL OF CLINICAL MICROBIOLOGY
LA English
DT Correction
C1 [Milillo, Michael; Kwak, Yoon I.; Snesrud, Erik; Waterman, Paige E.; Lesho, Emil; McGann, Patrick] Walter Reed Army Inst Res, Multidrug Resistant Organism Repository & Surveil, Silver Spring, MD 20910 USA.
RP Milillo, M (reprint author), Walter Reed Army Inst Res, Multidrug Resistant Organism Repository & Surveil, Silver Spring, MD 20910 USA.
NR 1
TC 0
Z9 0
U1 0
U2 2
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0095-1137
EI 1098-660X
J9 J CLIN MICROBIOL
JI J. Clin. Microbiol.
PD APR
PY 2015
VL 53
IS 4
BP 1460
EP 1460
DI 10.1128/JCM.00373-15
PG 1
WC Microbiology
SC Microbiology
GA CD8QA
UT WOS:000351359500077
PM 25788716
ER
PT J
AU Schlussel, AT
Lustik, MB
Johnson, EK
Maykel, JA
Champagne, BJ
Goldberg, JE
Steele, SR
AF Schlussel, Andrew T.
Lustik, Michael B.
Johnson, Eric K.
Maykel, Justin A.
Champagne, Brad J.
Goldberg, Joel E.
Steele, Scott R.
TI Do the Advantages of a Minimally Invasive Approach Remain in Complex
Colorectal Procedures? A Nationwide Comparison
SO DISEASES OF THE COLON & RECTUM
LA English
DT Article
DE Laparoscopy; Population database; Postoperative complications; Total
abdominal colectomy; Transverse colectomy
ID OPEN COLECTOMY; COLON-CANCER; LAPAROSCOPIC COLECTOMY; ASSISTED
RESECTION; TERM OUTCOMES; CLASICC TRIAL; CARE; DISPARITIES
AB BACKGROUND: Since the introduction of laparoscopic colectomy, experience and technology continue to improve. Although accepted for many colorectal conditions, its use and outcomes in complex procedures are less understood.
OBJECTIVE: The purpose of this work was to compare the perioperative outcomes of laparoscopic transverse colectomy and total abdominal colectomy (study group) with an open approach (comparative group) and the more established laparoscopic right, left, and sigmoid colectomies (control group).
DESIGN: This was a retrospective review of the Nationwide Inpatient Sample (2008-2011) of all patients undergoing elective right, left, sigmoid, total, or transverse colectomy as identified by International Classification of Diseases, Ninth Revision, Clinical Modification procedure codes. Risk-adjusted 30-day outcomes were assessed using regression modeling accounting for patient characteristics, comorbidities, and surgical procedures.
SETTINGS: The study included a national sample from a population database.
PATIENTS: There were 45,771 admissions: 2946 in the study group, 36,949 in the control group, and 5876 in the open comparative group.
MAIN OUTCOME MEASURES: Mortality was the primary outcome. Secondary outcomes included in-hospital complications, length of stay, and hospital charges.
RESULTS: The patients were predominantly white (73%), had private insurance (64%), and underwent surgery at urban centers (92%). Mortality was similar between the study and control groups (0.42% vs 0.51%; p = 0.52), with a higher complication rate in the study group (19% vs 14%; p < 0.01). The study group was also associated with a lower mortality rate compared with the open group (0.51% vs 2.20%; p < 0.01), which remained consistent after adjusting for covariates (OR, 0.38 [95% CI, 0.20-0.71]; p < 0.01). The study group had fewer complications overall compared with the open group (19% vs 27%; p < 0.01) and a shorter median length of stay (4.6 vs 6.3 days; p < 0.01).
LIMITATIONS: This was a retrospective study using an administrative database.
CONCLUSIONS: A laparoscopic approach for total abdominal and transverse colectomies has similar mortality rates and slightly higher complications than the more established laparoscopic colectomy procedures and improved perioperative outcomes when compared with an open technique (see Video, Supplemental Digital Content 1, http://links.lww.com/DCR/A178).
C1 [Schlussel, Andrew T.] Tripler Army Med Ctr, Dept Surg, Honolulu, HI 96859 USA.
[Lustik, Michael B.] Tripler Army Med Ctr, Dept Clin Invest, Honolulu, HI 96859 USA.
[Johnson, Eric K.; Steele, Scott R.] Madigan Army Med Ctr, Dept Surg, Ft Lewis, WA USA.
[Maykel, Justin A.] Univ Massachusetts, Mem Med Ctr, Div Colorectal Surg, Worcester, MA 01605 USA.
[Champagne, Brad J.] Univ Hosp Case Med Ctr, Dept Surg, Div Colorectal Surg, Cleveland, OH USA.
[Goldberg, Joel E.] Harvard Univ, Brigham & Womens Hosp, Sect Colorectal Surg, Sch Med, Boston, MA 02115 USA.
RP Steele, SR (reprint author), Madigan Army Med Ctr, 9040 Jackson Ave, Puyallup, WA 98433 USA.
EM harkersteele@mac.com
NR 24
TC 4
Z9 4
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0012-3706
EI 1530-0358
J9 DIS COLON RECTUM
JI Dis. Colon Rectum
PD APR
PY 2015
VL 58
IS 4
BP 431
EP 443
DI 10.1097/DCR.0000000000000325
PG 13
WC Gastroenterology & Hepatology; Surgery
SC Gastroenterology & Hepatology; Surgery
GA CD3IX
UT WOS:000350972900017
PM 25751800
ER
PT J
AU Massey, TC
AF Massey, T. Chris
TI Locally constrained nodal connectivity refinement procedures for
unstructured triangular finite element meshes
SO ENGINEERING WITH COMPUTERS
LA English
DT Article
DE Unstructured triangular mesh; Mesh quality; Nodal connectivity
AB This paper presents specific procedures for locally refining nodal connectivity of two-dimensional unstructured triangular meshes to improve the quality of the mesh as well as to increase solution accuracy and computational speed. Details of the procedure are outlined along with a discussion of similar work, and an example problem from hydrodynamics is shown.
C1 US Army Corps Engineers, Engn Res & Dev Ctr, Coastal & Hydraul Lab, Vicksburg, MS 39180 USA.
RP Massey, TC (reprint author), US Army Corps Engineers, Engn Res & Dev Ctr, Coastal & Hydraul Lab, Vicksburg, MS 39180 USA.
EM Chris.Massey@usace.army.mil
FU NRL
FX Portions of this work were initially performed while the author was
employed at the Oceanography Division of the Naval Research Laboratory
(NRL) and the remainder was completed at the U.S. Army Corps of
Engineers, Engineer Research and Development Center as part of the
Coastal Storm Modeling System Work Unit of the Flood and Coastal
Research program. The author would like to thank Ben Holladay, an NRL
STEP student at the time, for his efforts with some of the initial
Matlab coding and testing inside of MeshGUI and to acknowledge the
support of Dr. Cheryl Ann Blain of NRL in helping to fund some of the
initial work that is included in MeshGUI. The author would especially
like to thank the reviewers for their time, effort and useful comments
in preparing this paper.
NR 11
TC 0
Z9 0
U1 0
U2 1
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0177-0667
EI 1435-5663
J9 ENG COMPUT-GERMANY
JI Eng. Comput.
PD APR
PY 2015
VL 31
IS 2
BP 375
EP 386
DI 10.1007/s00366-014-0357-y
PG 12
WC Computer Science, Interdisciplinary Applications; Engineering,
Mechanical
SC Computer Science; Engineering
GA CD6MT
UT WOS:000351203900012
ER
PT J
AU Rush, JK
Astur, N
Scott, S
Kelly, DM
Sawyer, JR
Warner, WC
AF Rush, Jeremy K.
Astur, Nelson
Scott, Stephanie
Kelly, Derek M.
Sawyer, Jeffrey R.
Warner, William C., Jr.
TI Use of Magnetic Resonance Imaging in the Evaluation of Spondylolysis
SO JOURNAL OF PEDIATRIC ORTHOPAEDICS
LA English
DT Article
DE spondylolysis; adolescents; diagnosis; MRI; CT
ID LUMBAR PARS INTERARTICULARIS; LOW-BACK-PAIN; COMPUTED-TOMOGRAPHY;
STRESS-FRACTURES; NATURAL-HISTORY; FOLLOW-UP; SPONDYLOLISTHESIS; MRI;
ADOLESCENTS; CHILDREN
AB Background: In early studies, magnetic resonance imaging (MRI) had low sensitivity and positive predictive value in the evaluation of the pars interarticularis pathology; however, more recent reports have suggested an expanded role for MRI. The purpose of the present study was to evaluate the effectiveness of MRI in the diagnosis of pars injuries and compare it to computed tomography (CT), which was used as the reference "gold standard" for the detection of fractures.
Methods: The radiographic and clinic data of 93 adolescents and young adults with a presumptive diagnosis of spondylolysis based upon history and clinic examination were reviewed. Only 26 patients who had MRI and CT images obtained within 30 days of each other were included. All images were reviewed by a fellowship-trained musculoskeletal radiologist and fellowship-trained pediatric orthopaedist.
Results: Overall, 39 individual pars lesions (stress reaction or fracture) were identified. MRI was effective in identifying 36 pars lesions. MRI identified 11 lesions in 9 patients with negative CT. Seven of these lesions were stress reactions (grade 1), whereas 4 were frank fractures. Three pars injuries were noted on CT while the MRI was negative.
Conclusions: MRI is an effective method (92% sensitivity) for detecting pars injuries. It can detect stress reactions when a fracture is not visible on CT scan, allowing early treatment of these prelysis lesions. The 92% sensitivity of MRI is comparable with that of other diagnostic modalities such as bone scan, with the advantage of no radiation exposure. MRI should be strongly considered as the advanced imaging modality of choice in the evaluation of patients with suspected spondylolysis.
C1 [Rush, Jeremy K.] Ft Sam, Brooke Army Med Ctr, Houston, TX USA.
[Astur, Nelson; Scott, Stephanie; Kelly, Derek M.; Sawyer, Jeffrey R.; Warner, William C., Jr.] Univ Tennessee, Dept Orthopaed Surg, Le Bonheur Childrens Hosp, Campbell Clin, Memphis, TN 38138 USA.
RP Warner, WC (reprint author), Univ Tennessee, Dept Orthopaed Surg, Le Bonheur Childrens Hosp, Campbell Clin, 1400 S Germantown Rd Germantown, Memphis, TN 38138 USA.
EM wcwarner@comcast.net
RI Astur, Nelson/F-3267-2015
OI Astur, Nelson/0000-0002-2608-2118
NR 25
TC 3
Z9 3
U1 6
U2 22
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0271-6798
EI 1539-2570
J9 J PEDIATR ORTHOPED
JI J. Pediatr. Orthop.
PD APR-MAY
PY 2015
VL 35
IS 3
BP 271
EP 275
PG 5
WC Orthopedics; Pediatrics
SC Orthopedics; Pediatrics
GA CD2HF
UT WOS:000350895500011
PM 24978120
ER
PT J
AU Mrozek, RA
Leighliter, B
Gold, CS
Beringer, IR
Yu, JH
VanLandingham, MR
Moy, P
Foster, MH
Lenhart, JL
AF Mrozek, Randy A.
Leighliter, Brad
Gold, Christopher S.
Beringer, Ian R.
Yu, Jian H.
VanLandingham, Mark R.
Moy, Paul
Foster, Mark H.
Lenhart, Joseph L.
TI The relationship between mechanical properties and ballistic penetration
depth in a viscoelastic gel
SO JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
LA English
DT Article
ID PRESSURE-SENSITIVE ADHESIVES; THERMOPLASTIC ELASTOMER GELS; TRIBLOCK
COPOLYMER GELS; DOUBLE-NETWORK GELS; POLYMER GELS; GELATIN; IMPACT;
TEMPERATURE; RHEOLOGY; BEHAVIOR
AB The fundamental material response of a viscoelastic material when impacted by a ballistic projectile has important implication for the defense, law enforcement, and medical communities particularly for the evaluation of protective systems. In this paper, we systematically vary the modulus and toughness of a synthetic polymer gel to determine their respective influence on the velocity-dependent penetration of a spherical projectile. The polymer gels were characterized using tensile, compression, and rheological testing taking special care to address the unique challenges associated with obtaining high fidelity mechanical data on highly conformal materials. The depth of penetration data was accurately described using the elastic Froude number for viscoelastic gels ranging in Young's modulus from similar to 60 to 630 kPa. The minimum velocity of penetration was determined to scale with the gel toughness divided by the gel modulus, a qualitative estimate for the zone of deformation size scale upon impact. We anticipate that this work will provide insight into the critical material factors that control ballistic penetration behavior in soft materials and aid in the design and development of new ballistic testing media. Published by Elsevier Ltd.
C1 [Mrozek, Randy A.; Leighliter, Brad; Gold, Christopher S.; Beringer, Ian R.; Yu, Jian H.; VanLandingham, Mark R.; Moy, Paul; Foster, Mark H.; Lenhart, Joseph L.] US Army Res Lab, Aberdeen, MD 21005 USA.
RP Mrozek, RA (reprint author), US Army Res Lab, Aberdeen, MD 21005 USA.
EM randy.a.mrozek.civ@mail.mil; jospeh.l.lenhart.civ@mail.mil
NR 32
TC 4
Z9 4
U1 6
U2 38
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1751-6161
EI 1878-0180
J9 J MECH BEHAV BIOMED
JI J. Mech. Behav. Biomed. Mater.
PD APR
PY 2015
VL 44
BP 109
EP 120
DI 10.1016/j.jmbbm.2015.01.001
PG 12
WC Engineering, Biomedical; Materials Science, Biomaterials
SC Engineering; Materials Science
GA CD1LK
UT WOS:000350836200012
PM 25637822
ER
PT J
AU Bates, ME
Fox-Lent, C
Seymour, L
Wender, BA
Linkov, I
AF Bates, Matthew E.
Fox-Lent, Cate
Seymour, Linda
Wender, Ben A.
Linkov, Igor
TI Life cycle assessment for dredged sediment placement strategies
SO SCIENCE OF THE TOTAL ENVIRONMENT
LA English
DT Article
DE Life-cycle assessment; Dredging; Sediments; Beneficial use; Long Island
Sound
ID MULTICRITERIA DECISION-ANALYSIS; REMEDIATION
AB Dredging to maintain navigable waterways is important for supporting trade and economic sustainability. Dredged sediments are removed from the waterways and then must be managed in a way that meets regulatory standards and properly balances management costs and risks. Selection of a best management alternative often results in stakeholder conflict regarding tradeoffs between local environmental impacts associated with less expensive alternatives (e.g., open water placement), more expensive measures that require sediment disposal in constructed facilities far away (e.g., landfills), or beneficial uses that may be perceived as risky (e.g., beach nourishment or island creation). Current sediment-placement decisions often focus on local and immediate environmental effects from the sediment itself, ignoring a variety of distributed and long-term effects from transportation and placement activities. These extended effects have implications for climate change, resource consumption, and environmental and human health, which may be meaningful topics for many stakeholders not currently considered. Life-Cycle Assessment (LCA) provides a systematic and quantitative method for accounting for this wider range of impacts and benefits across all sediment management project stages and time horizons. This paper applies a cradle-to-use LCA to dredged-sediment placement through a comparative analysis of potential upland, open water, and containment-island placement alternatives in the Long Island Sound region of NY/CT. Results suggest that, in cases dealing with uncontaminated sediments, upland placement may be the most environmentally burdensome alternative, per ton-kilometer of placed material, due to the emissions associated with diesel fuel combustion and electricity production and consumption required for the extra handling and transportation. These results can be traded-off with the ecosystem impacts of the sediments themselves in a decision-making framework. Published by Elsevier B.V.
C1 [Bates, Matthew E.; Fox-Lent, Cate; Linkov, Igor] US Army Corps Engineers, Engineer Res & Dev Ctr, Environm Lab, Concord, MA 01742 USA.
[Seymour, Linda] MIT, Dept Civil & Environm Engn, Cambridge, MA 02139 USA.
[Wender, Ben A.] Arizona State Univ, Sch Sustainable Engn & Built Environm, Phoenix, AZ 85004 USA.
RP Bates, ME (reprint author), US Army Corps Engineers, Engineer Res & Dev Ctr, Environm Lab, 696 Virginia Rd, Concord, MA 01742 USA.
EM Matthew.E.Bates@usace.army.mil; Catherine.Fox-Lent@usace.army.mil;
lseymour@mit.edu; bwender@asu.edu; Igor.Linkov@usace.army.mil
FU USACE Dredging Operations and Environmental Research program
FX The authors acknowledge funding from the USACE Dredging Operations and
Environmental Research program. The authors thank Dr. Todd Bridges as
program manager and Mary Hwang for her formatting assistance. Permission
to publish this work was granted by the USACE Chief of Engineers.
NR 28
TC 5
Z9 5
U1 8
U2 37
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0048-9697
EI 1879-1026
J9 SCI TOTAL ENVIRON
JI Sci. Total Environ.
PD APR 1
PY 2015
VL 511
BP 309
EP 318
DI 10.1016/j.scitotenv.2014.11.003
PG 10
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA CC6YC
UT WOS:000350513900032
PM 25553545
ER
PT J
AU Chapman, ED
Hearn, AR
Singer, GP
Brostoff, WN
LaCivita, PE
Klimley, AP
AF Chapman, Eric D.
Hearn, Alex R.
Singer, Gabriel P.
Brostoff, William N.
LaCivita, Peter E.
Klimley, A. Peter
TI Movements of steelhead (Oncorhynchus mykiss) smolts migrating through
the San Francisco Bay Estuary
SO ENVIRONMENTAL BIOLOGY OF FISHES
LA English
DT Article
DE Steelhead; Migration; Tide; Acoustic telemetry; Sacramento River; San
Francisco Bay Estuary
ID JUVENILE STEELHEAD; CHINOOK SALMON; RIVER; SURVIVAL; HATCHERY;
CALIFORNIA; TELEMETRY; PATTERNS; BEHAVIOR; COLUMBIA
AB We used acoustic telemetry to monitor the out-migration of 1,000 steelhead smolts (Oncorhynchus mykiss) through the San Francisco Bay Estuary during spring of 2009 and 2010. The smolts transited the estuary rapidly (2-4 days) and utilized flows in the main channel during their migration. Fewer smolts were detected in marinas, tributaries and other shallow areas surrounding the estuary. Many of the smolts made repeated upriver and downriver movements that were related to the tidal flow, moving upstream during flood tides and downstream during ebb tides. These results show that steelhead smolts migrating from the Sacramento River transit rapidly through the lower reaches and do not use the estuary for feeding, rearing, or smoltification purposes.
C1 [Chapman, Eric D.; Hearn, Alex R.; Singer, Gabriel P.; Klimley, A. Peter] Univ Calif Davis, Dept Wildlife Fish & Conservat Biol, Davis, CA 95616 USA.
[Brostoff, William N.; LaCivita, Peter E.] US Army Corps Engineers, San Francisco, CA 94103 USA.
RP Chapman, ED (reprint author), Univ Calif Davis, Dept Wildlife Fish & Conservat Biol, 1331 Acad Surge,One Shields Ave, Davis, CA 95616 USA.
EM edchapman@ucdavis.edu
FU US Army Corps of Engineers, San Francisco District
FX This study was funded by the US Army Corps of Engineers, San Francisco
District to provide information to the Long Term Management Strategy for
fish movements in San Francisco Bay relative to dredging and dredged
material placement operations. The research presented in this manuscript
was conducted under a protocol that was reviewed and approved by the
University of California Davis Institutional Animal Care and Use
Committee (IUCAC). The authors would like to thank Chuck Morton and
Charlotte Cashin for scheduling boat time and assisting on the Caltrans
vessel with the maintenance of the monitors deployed on bridges. We
greatly appreciate the help from everyone at the UC Davis Biotelemetry
Laboratory (Mike Thomas, Denise Tu, Michelle Buckhorn, Anna Steel and
Jamilynn Poletto) for volunteering their time to assist with the
surgical implantation of the tags and for assistance in maintaining the
arrays. We would also like to thank Arnold Ammann and Cyril Michel at
the Santa Cruz office of the NMFS for maintaining the database. Thanks
to Kurt Brown, Scott Hamelberg and Kevin Niemala at the Coleman National
Fish Hatchery.
NR 29
TC 0
Z9 0
U1 1
U2 14
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0378-1909
EI 1573-5133
J9 ENVIRON BIOL FISH
JI Environ. Biol. Fishes
PD APR
PY 2015
VL 98
IS 4
BP 1069
EP 1080
DI 10.1007/s10641-014-0341-9
PG 12
WC Ecology; Marine & Freshwater Biology
SC Environmental Sciences & Ecology; Marine & Freshwater Biology
GA CC7RY
UT WOS:000350567300009
ER
PT J
AU Min, KS
Ryan, PM
AF Min, Kyong S.
Ryan, Paul M.
TI Arthroscopic Allograft Cartilage Transfer for Osteochondral Defects of
the Talus
SO ARTHROSCOPY TECHNIQUES
LA English
DT Article
ID LESIONS; TRANSPLANTATION
AB Arthroscopic treatment of osteochondral defects is well established but has had mixed results in larger lesions and revision operations. Particulated allograft cartilage transfer may provide an arthroscopic option for lesions that would otherwise have been treated through open approaches or osteotomies. The procedure is performed under noninvasive distraction with standard arthroscopic portals.
C1 [Min, Kyong S.] Brian Allgood Army Community Hosp, Seoul, South Korea.
[Ryan, Paul M.] Tripler Army Med Ctr, Honolulu, HI 96859 USA.
RP Min, KS (reprint author), Alpha Co, Brian Allgood Army Community Hosp, 121st CSH,Unit 15244,Box 437, APO, AP 96205 USA.
EM kyong.s.min@gmail.com
NR 5
TC 1
Z9 1
U1 0
U2 1
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 2212-6287
J9 ARTHROSC TEC
JI Arthrosc. Tec.
PD APR
PY 2015
VL 4
IS 2
BP E175
EP E178
DI 10.1016/j.eats.2015.01.003
PG 4
WC Orthopedics
SC Orthopedics
GA DU5AX
UT WOS:000382225400015
PM 26052496
ER
PT J
AU Peltzer, J
Lund, K
Lataillade, JJ
AF Peltzer, Juliette
Lund, Kyle
Lataillade, Jean-Jacques
TI Paracrine properties of Mesenchymal Stromal Cells
SO BULLETIN DE L ACADEMIE NATIONALE DE MEDECINE
LA French
DT Article
DE MESENCHYMAL STROMAL CELLS; CELL- AND TISSUE-BASED THERAPY; Exo-SOMES
ID THERAPY POSITION STATEMENT; HEMATOPOIETIC STEM-CELLS; SUPPRESS
T-LYMPHOCYTE; ACUTE LUNG INJURY; BONE-MARROW; INTERNATIONAL-SOCIETY;
IN-VITRO; SECRETION; MICROVESICLES; INFLAMMATION
AB Mesenchymal stromal cells are multipotent cells found in a large number of adult tissues. Their ability to participate in the repair of these damaged tissues is the origin of the enthusiasm that they elicit in the field of cell therapy. It gradually became apparent that their ability to change a pathological environment is more related to their ability to modulate the behavior of other cell types than their capacity of differentiation. Recent years have expanded the scope of our knowledge about their way of communication with their environment but also the amount of information that they receive from this environment. In this brief review, we will present some of the mechanisms by which sMSCs can communicate remotely with other cell types and how it currently appears possible to direct the secretion pattern of these cells
C1 [Peltzer, Juliette; Lund, Kyle; Lataillade, Jean-Jacques] IRBA, Dept Soutien Med Chirurg Forces, Unite Therapie Cellulaire & Reparat Tissulaire, BP 73, F-91223 Bretigny Sur Orge, France.
[Peltzer, Juliette; Lund, Kyle; Lataillade, Jean-Jacques] Ctr Transfus Sanguine Armees, F-92141 Clamart, France.
[Lund, Kyle] US Army, Med Res & Mat Command, Ft Detrick, MD 21702 USA.
RP Peltzer, J (reprint author), IRBA, Dept Soutien Med Chirurg Forces, Unite Therapie Cellulaire & Reparat Tissulaire, BP 73, F-91223 Bretigny Sur Orge, France.
NR 50
TC 0
Z9 0
U1 1
U2 1
PU ELSEVIER MASSON SAS EDITEUR
PI ISSY LES MOULINEAUX CEDEX
PA 62, RUE CAMILLE DESMOULINS, ISSY LES MOULINEAUX CEDEX, 92442, FRANCE
SN 0001-4079
J9 B ACAD NAT MED PARIS
JI Bull. Acad. Natl. Med.
PD APR-MAY
PY 2015
VL 199
IS 4-5
BP 501
EP 514
PG 14
WC Medicine, General & Internal
SC General & Internal Medicine
GA DQ7JW
UT WOS:000379384200005
PM 27509668
ER
PT J
AU Bodhidatta, L
Abente, E
Neesanant, P
Nakjarung, K
Sirichote, P
Bunyarakyothin, G
Vithayasai, N
Mason, CJ
AF Bodhidatta, Ladaporn
Abente, Eugenio
Neesanant, Pimmnapar
Nakjarung, Kaewkanya
Sirichote, Pantip
Bunyarakyothin, Gaysorn
Vithayasai, Niyada
Mason, Carl J.
TI Molecular Epidemiology and Genotype Distribution of Noroviruses in
Children in Thailand From 2004 to 2010: A Multi-Site Study
SO JOURNAL OF MEDICAL VIROLOGY
LA English
DT Article
DE pediatric; diarrhea; surveillance
ID NORWALK-LIKE VIRUSES; ACUTE GASTROENTERITIS; GENETIC DIVERSITY;
UNITED-STATES; CHIANG-MAI; VACCINE DEVELOPMENT; OUTBREAKS; SAPOVIRUS;
EMERGENCE; VARIANTS
AB This study identified norovirus in children presenting with acute gastroenteritis and determined the capsid genotypes of the circulating norovirus strains in multiple regions in Thailand during October 2004 to December 2006 and March 2008 to August 2010. A total of 7,420 stool samples were collected from both cases (3621) and controls (3799). The stool samples were screened by two real-time RT-PCR assays to detect genogroup I and genogroup II noroviruses. Norovirus-positive samples were identified in 516 cases (14.3%) and 181 controls (4.8%) with more than half of norovirus positive samples from 7-24 months old children. Positive samples were sequenced and genotyped for the capsid gene. GII.4 was the genotype observed most frequently (56.4%) followed by GII.3 (28.2%). Five peaks of infection were observed, with predominant capsid genotypes that alternated during the surveillance periods between GII.4 and GII.3. Analyses of positive samples showed variation in genotype from each region as well as from different study periods. This emphasizes the importance of multi-site studies to investigate norovirus epidemiology. Additionally, the observed regional and temporal variations suggest that a systematic nation-wide surveillance effort in Thailand is needed to track the continually changing norovirus epidemiology. J. Med. Virol. 87:664-674, 2015. (c) 2015 Wiley Periodicals, Inc.
C1 [Bodhidatta, Ladaporn; Abente, Eugenio; Neesanant, Pimmnapar; Nakjarung, Kaewkanya; Mason, Carl J.] Armed Forces Res Inst Med Sci, Dept Enter Dis, Bangkok 10400, Thailand.
[Sirichote, Pantip; Bunyarakyothin, Gaysorn] Minist Publ Hlth, Dept Med Sci, Nonthaburi, Thailand.
[Vithayasai, Niyada] Queen Sirikit Natl Inst Child Hlth, Bangkok, Thailand.
RP Bodhidatta, L (reprint author), Armed Forces Res Inst Med Sci, Dept Enter Dis, 315-6 Rajvithi Rd, Bangkok 10400, Thailand.
EM LadapornB@afrims.org
OI MASON, CARL/0000-0002-3676-2811; Abente, Eugenio/0000-0002-3390-2786
FU Armed Forces Health Surveillance Center, Division of Global Emerging
Infections Surveillance and Response System (AFHSC-GEIS) [AFHSC-GEIS]
FX Grant sponsor: Armed Forces Health Surveillance Center, Division of
Global Emerging Infections Surveillance and Response System
(AFHSC-GEIS); Grant number: AFHSC-GEIS.
NR 59
TC 8
Z9 8
U1 0
U2 4
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0146-6615
EI 1096-9071
J9 J MED VIROL
JI J. Med. Virol.
PD APR
PY 2015
VL 87
IS 4
BP 664
EP 674
DI 10.1002/jmv.24108
PG 11
WC Virology
SC Virology
GA CB0EX
UT WOS:000349299500017
PM 25649836
ER
PT J
AU Champagne, V
Helfritch, D
AF Champagne, V.
Helfritch, D.
TI Critical Assessment 11: Structural repairs by cold spray
SO MATERIALS SCIENCE AND TECHNOLOGY
LA English
DT Article
DE Cold spray; Repair; Critical assessment; Aircraft; Dimensional
restoration; Damage; Wear; Corrosion; Remanufacturing
ID DEPOSITION; COATINGS
AB The deposition of material by cold spray is a relatively new technology. It is often applied to coating applications but can be used for the repair of defects in and damage to metal structures. The use of cold spray for repair is often favoured because, unlike thermal spray methods, cold spray does not bring about heat related damage to the component under repair. The status of the technology and the barriers to widespread commercial application are assessed. The types of repair that have been made with cold spray are discussed, and the unique features of cold spray that permit successful repairs are demonstrated.
C1 [Champagne, V.] US Army, Res Lab, Aberdeen Proving Ground, MD USA.
[Helfritch, D.] TKC Global, Hearndon, VA 20171 USA.
RP Helfritch, D (reprint author), TKC Global, Hearndon, VA 20171 USA.
EM Dennis.Helfritch@tkcglobal.com
NR 35
TC 9
Z9 9
U1 2
U2 25
PU MANEY PUBLISHING
PI LEEDS
PA STE 1C, JOSEPHS WELL, HANOVER WALK, LEEDS LS3 1AB, W YORKS, ENGLAND
SN 0267-0836
EI 1743-2847
J9 MATER SCI TECH-LOND
JI Mater. Sci. Technol.
PD APR
PY 2015
VL 31
IS 6
BP 627
EP 634
DI 10.1179/1743284714Y.0000000723
PG 8
WC Materials Science, Multidisciplinary; Metallurgy & Metallurgical
Engineering
SC Materials Science; Metallurgy & Metallurgical Engineering
GA AZ6QE
UT WOS:000348343000001
ER
PT J
AU Day, JB
Basavanna, U
AF Day, J. B.
Basavanna, U.
TI Magnetic bead based immuno-detection of Listeria monocytogenes and
Listeria ivanovii from infant formula and leafy green vegetables using
the Bio-Plex suspension array system
SO FOOD MICROBIOLOGY
LA English
DT Article
DE Listeria; Detection; Foods; Macrophage; Bio-Plex
ID REAL-TIME PCR; ESCHERICHIA-COLI O157-H7; CELL-CULTURE METHOD; TO-EAT
FOODS; UNITED-STATES; EPIDEMIC LISTERIOSIS; SUBSEQUENT DETECTION;
OUTBREAK; SALMONELLA; VIRULENCE
AB Listeriosis, a disease contracted via the consumption of foods contaminated with pathogenic Listeria species, can produce severe symptoms and high mortality in susceptible people and animals. The development of molecular methods and immuno-based techniques for detection of pathogenic Listeria in foods has been challenging due to the presence of assay inhibiting food components. In this study, we utilize a macrophage cell culture system for the isolation and enrichment of Listeria monocytogenes and Listeria ivanovii from infant formula and leafy green vegetables for subsequent identification using the Luminex xMAP technique. Macrophage monolayers were exposed to infant formula, lettuce and celery contaminated with L. monocytogenes or L. ivanovii. Magnetic microspheres conjugated to Listeria specific antibody were used to capture Listeria from infected macrophages and then analyzed using the Bio-Plex 200 analyzer. As few as 10 CFU/mL or g of L. monocytogenes was detected in all foods tested. The detection limit for L. ivanovii was 10 CFU/mL in infant formula and 100 CFU/g in leafy greens. Microsphere bound Listeria obtained from infected macrophage lysates could also be isolated on selective media for subsequent confirmatory identification. This method presumptively identifies L. monocytogenes and L. ivanovii from infant formula, lettuce and celery in less than 28 h with confirmatory identifications completed in less than 48 h. Published by Elsevier Ltd.
C1 [Day, J. B.] US FDA, Ctr Food Safety & Appl Nutr, College Pk, MD 20740 USA.
[Basavanna, U.] US Army, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA.
RP Day, JB (reprint author), US FDA, Ctr Food Safety & Appl Nutr, 5100 Paint Branch Pkwy, College Pk, MD 20740 USA.
EM james.day@fda.hhs.gov
NR 56
TC 5
Z9 5
U1 4
U2 57
PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
PI LONDON
PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND
SN 0740-0020
EI 1095-9998
J9 FOOD MICROBIOL
JI Food Microbiol.
PD APR
PY 2015
VL 46
BP 564
EP 572
DI 10.1016/j.fm.2014.09.020
PG 9
WC Biotechnology & Applied Microbiology; Food Science & Technology;
Microbiology
SC Biotechnology & Applied Microbiology; Food Science & Technology;
Microbiology
GA AW0OM
UT WOS:000345992200070
PM 25475329
ER
PT J
AU Buonora, JE
Yarnell, AM
Lazarus, RC
Mousseau, M
Latour, LL
Rizoli, SB
Baker, AJ
Rhind, SG
Diaz-Arrastia, R
Mueller, GP
AF Buonora, John E.
Yarnell, Angela M.
Lazarus, Rachel C.
Mousseau, Michael
Latour, Lawrence L.
Rizoli, Sandro B.
Baker, Andrew J.
Rhind, Shawn G.
Diaz-Arrastia, Ramon
Mueller, Gregory P.
TI Multivariate analysis of traumatic brain injury: development of an
assessment score
SO FRONTIERS IN NEUROLOGY
LA English
DT Article
DE biomarkers; assessment score; human; mild traumatic brain injury;
multivariate analysis
ID C-TERMINAL HYDROLASE; FIBRILLARY ACIDIC PROTEIN; NEURON-SPECIFIC
ENOLASE; CREATINE-KINASE-BB; MILD HEAD-INJURY; SERUM-LEVELS;
CEREBROSPINAL-FLUID; NEUROTROPHIC FACTOR; OXIDATIVE STRESS; ICE HOCKEY
AB Important challenges for the diagnosis and monitoring of mild traumatic brain injury (mTBI) include the development of plasma biomarkers for assessing neurologic injury, monitoring pathogenesis, and predicting vulnerability for the development of untoward neurologic outcomes. While several biomarker proteins have shown promise in this regard, used individually, these candidates lack adequate sensitivity and/or specificity for making a definitive diagnosis or identifying those at risk of subsequent pathology. The objective for this study was to evaluate a panel of six recognized and novel biomarker candidates for the assessment of TB I in adult patients. The biomarkers studied were selected on the basis of their relative brain-specificities and potentials to reflect distinct features of TBI mechanisms including (1) neuronal damage assessed by neuron-specific enolase (NSE) and brain derived neurotrophic factor (BDNF); (2) oxidative stress assessed by peroxiredoxin 6 (PRDX6); (3) glial damage and gliosis assessed by glial fibrillary acidic protein and S100 calcium binding protein beta (S100b); (4) immune activation assessed by monocyte chemoattractant protein 1/chemokine (C-C motif) ligand 2 (MCP1/CCL2); and (5) disruption of the intercellular adhesion apparatus assessed by intercellular adhesion protein-5 (ICAM-5). The combined fold-changes in plasma levels of PRDX6, S100b, MCP1, NSE, and BDNF resulted in the formulation of a TBI assessment score that identified mTBI with a receiver operating characteristic (ROC) area under the curve of 0.97, when compared to healthy controls. This research demonstrates that a profile of biomarker responses can be used to formulate a diagnostic score that is sensitive for the detection of mTBI. Ideally, this multivariate assessment strategy will be refined with additional biomarkers that can effectively assess the spectrum of TBI and identify those at particular risk for developing neuropathologies as consequence of a mTBI event.
C1 [Buonora, John E.; Lazarus, Rachel C.; Mousseau, Michael; Mueller, Gregory P.] Uniformed Serv Univ Hlth Sci, Dept Anat Physiol & Genet, Bethesda, MD 20814 USA.
[Buonora, John E.] US Army, Grad Program Anesthesia Nursing, Acad Hlth Sci, Ft Sam Houston, TX USA.
[Yarnell, Angela M.] Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci Res, Behav Biol Branch, Silver Spring, MD USA.
[Latour, Lawrence L.] NINDS, Stroke Branch, Bethesda, MD 20892 USA.
[Latour, Lawrence L.; Rhind, Shawn G.] Toronto Res Ctr, Def Res & Dev Canada, Toronto, ON, Canada.
[Rizoli, Sandro B.; Baker, Andrew J.] Univ Toronto, St Michaels Hosp, Dept Anesthesia, Keenan Res Ctr,Li Ka Shing Knowledge Inst, Toronto, ON, Canada.
[Rizoli, Sandro B.; Baker, Andrew J.] Univ Toronto, St Michaels Hosp, Dept Surg, Keenan Res Ctr,Li Ka Shing Knowledge Inst, Toronto, ON, Canada.
[Rizoli, Sandro B.; Baker, Andrew J.] Univ Toronto, St Michaels Hosp, Dept Crit Care Med, Keenan Res Ctr,Li Ka Shing Knowledge Inst, Toronto, ON, Canada.
[Baker, Andrew J.] Univ Toronto, Cara Phelan Ctr Trauma Res, Brain Injury Lab, Keenan Res Ctr,Li Ka Shing Knowledge Inst, Toronto, ON, Canada.
[Diaz-Arrastia, Ramon] Uniformed Serv Univ Hlth Sci, Ctr Neurosci & Regenerat Med, Bethesda, MD 20814 USA.
RP Mueller, GP (reprint author), Uniformed Serv Univ Hlth Sci USU, Dept Anat Physiol & Genet, Room C2117,4301 Jones Bridge Rd, Bethesda, MD 20814 USA.
EM gregory.mueller@usuhs.edu
FU Defense Medical Research and Development; Center for Neuroscience and
Regenerative Medicine; TriService Nursing Research Program Grant
[HT9404-12-1-TS13]; Department of National Defense of Canada (DND)
through the Technology Investment Fund (TIF) program
FX Principle source of funding was provided by a grant from the Defense
Medical Research and Development, the Center for Neuroscience and
Regenerative Medicine and the TriService Nursing Research Program Grant
# HT9404-12-1-TS13. The authors also gratefully acknowledge the support
of the Department of National Defense of Canada (DND) through the
Technology Investment Fund (TIF) program. We also would like to
acknowledge Mr. James Freedy for his contribution to the development of
the single and multiplex assay platforms; Ms. Maria Shiu and Mr. Alex Di
Battista for their technical assistance with sample collection and
processing. The opinions expressed here are those of the author(s), and
are not necessarily representative of those of the Uniformed Services
University of the Health Sciences (USUHS), the United States Army and/or
the Department of Defense, USA.
NR 67
TC 7
Z9 7
U1 0
U2 1
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA PO BOX 110, EPFL INNOVATION PARK, BUILDING I, LAUSANNE, 1015,
SWITZERLAND
SN 1664-2295
J9 FRONT NEUROL
JI Front. Neurol.
PD MAR 30
PY 2015
VL 6
AR UNSP 68
DI 10.3389/fneur.2015.00068
PG 11
WC Clinical Neurology; Neurosciences
SC Neurosciences & Neurology
GA CU8EV
UT WOS:000363775100001
PM 25870583
ER
PT J
AU Hunsawong, T
Sunintaboon, P
Warit, S
Thaisomboonsuk, B
Jarman, RG
Yoon, IK
Ubol, S
Fernandez, S
AF Hunsawong, Taweewun
Sunintaboon, Panya
Warit, Saradee
Thaisomboonsuk, Butsaya
Jarman, Richard G.
Yoon, In-Kyu
Ubol, Sukathida
Fernandez, Stefan
TI A novel dengue virus serotype-2 nanovaccine induces robust humoral and
cell-mediated immunity in mice
SO VACCINE
LA English
DT Article
DE Dengue virus; Dengue nanovaccine; Nanoparticle-based vaccine;
Immunostimulatory effect; Swiss albino mice
ID ENVELOPE DOMAIN III; ANTIBODY-RESPONSE; DENDRITIC CELL; T-CELLS;
VACCINE; NANOPARTICLES; INFECTION; ANTIGEN; INDUCTION; EFFICACY
AB Dengue virus (DENV), a member of the Flaviviridae family, can be transmitted to humans through the bite of infected Aedes mosquitoes. The incidence of dengue has increased worldwide over the past few decades. Inadequate vector control, changing global ecology, increased urbanization, and faster global travel are factors enhancing the rapid spread of the virus and its vector. In the absence of specific antiviral treatments, the search for a safe and effective vaccine grows more imperative. Many strategies have been utilized to develop dengue vaccines. Here, we demonstrate the immunogenic properties of a novel dengue nanovaccine (DNV), composed of ultraviolet radiation (UV)-inactivated DENV-2, which has been loaded into the nanopartides containing chitosan/Mycobacterium bovis Bacillus Calmette-Guerin cell wall components (CS/BCG-NPs). We investigated the immunogenicity of DNV in a Swiss albino mouse model. Inoculation with various concentrations of vaccine (0.3, 1, 3 and 10 mu g/dose) with three doses, 15-day apart, induced strong anti-dengue IgM and IgG antibodies in the mouse serum along with neutralizing antibody against DENV-2 reference strain (16681), a clinical-isolate strain (00745/10) and the mouse-adapted New Guinea-C (NGC) strain. Cytokine and chemokine secretion in the serum of DNV-immunized mice showed elevated levels of IFN-gamma, IL-2, IL-5, IL-12p40, IL-12p70, IL-17, eotaxin and RANTES, all of which have varying immune functions. Furthermore, we observed a DNV dose-dependent increase in the frequencies of IFN-gamma-producing CD4(+) and CD8(+) T cells after in vitro stimulation of nucleated cells. Based on these findings, DNV has the potential to become a candidate dengue vaccine. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
C1 [Hunsawong, Taweewun; Ubol, Sukathida] Mahidol Univ, Fac Sci, Dept Microbiol, Bangkok 10700, Thailand.
[Hunsawong, Taweewun; Thaisomboonsuk, Butsaya; Yoon, In-Kyu; Fernandez, Stefan] Armed Force Res Inst Med Sci, Dept Virol, Bangkok, Thailand.
[Sunintaboon, Panya] Mahidol Univ, Fac Sci, Dept Chem, Bangkok 10400, Thailand.
[Warit, Saradee] Natl Sci & Technol Dev Agcy, Natl Ctr Genet Engn & Biotechnol, TB Res Lab, Pathum Thani, Thailand.
[Jarman, Richard G.] Walter Reed Army Inst Res, Viral Dis Branch, Bethesda, MD USA.
RP Ubol, S (reprint author), USAMC AFRIMS, Dept Virol, 315-6 Ratchavithi Rd Payathai, Bangkok, Thailand.
EM sukathida.ubo@mahidol.ac.th; Stafan.Fernandez@afrims.org
NR 61
TC 5
Z9 5
U1 3
U2 13
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0264-410X
EI 1873-2518
J9 VACCINE
JI Vaccine
PD MAR 30
PY 2015
VL 33
IS 14
BP 1702
EP 1710
DI 10.1016/j.vaccine.2015.02.016
PG 9
WC Immunology; Medicine, Research & Experimental
SC Immunology; Research & Experimental Medicine
GA CF6JA
UT WOS:000352661800009
PM 25701315
ER
PT J
AU Ward, CL
Sanchez, CJ
Pollot, BE
Romano, DR
Hardy, SK
Becerra, SC
Rathbone, CR
Wenke, JC
AF Ward, Catherine L.
Sanchez, Carlos J., Jr.
Pollot, Beth E.
Romano, Desiree R.
Hardy, Sharanda K.
Becerra, Sandra C.
Rathbone, Christopher R.
Wenke, Joseph C.
TI Soluble factors from biofilms of wound pathogens modulate human bone
marrow-derived stromal cell differentiation, migration, angiogenesis,
and cytokine secretion
SO BMC MICROBIOLOGY
LA English
DT Article
DE Staphylococcus aureus; Pseudomonas aeruginosa; Biofilm; Mesenchymal
stromal cells; Wound healing; Differentiation; Angiogenesis
ID MESENCHYMAL STEM-CELLS; TOLL-LIKE RECEPTORS; TNF-ALPHA; IN-VITRO;
ANTIMICROBIAL PEPTIDE; EXPRESSION; LL-37; KERATINOCYTES; INFLAMMATION;
FIBROBLASTS
AB Background: Chronic, non-healing wounds are often characterized by the persistence of bacteria within biofilms - aggregations of cells encased within a self-produced polysaccharide matrix. Biofilm bacteria exhibit unique characteristics from planktonic, or culture-grown, bacterial phenotype, including diminished responses to antimicrobial therapy and persistence against host immune responses. Mesenchymal stromal cells (MSCs) are host cells characterized by their multifunctional ability to undergo differentiation into multiple cell types and modulation of host-immune responses by secreting factors that promote wound healing. While these characteristics make MSCs an attractive therapeutic for wounds, these pro-healing activities may be differentially influenced in the context of an infection (i.e., biofilm related infections) within chronic wounds. Herein, we evaluated the effect of soluble factors derived from biofilms of clinical isolates of Staphylococcus aureus and Pseudomonas aeruginosa on the viability, differentiation, and paracrine activity of human MSCs to evaluate the influence of biofilms on MSC activity in vitro.
Results: Exposure of MSCs to biofilm-conditioned medias of S. aureus and P. aeruginosa resulted in reductions in cell viability, in part due to activation of apoptosis. Similarly, exposure to soluble factors from biofilms was also observed to diminish the migration ability of cells and to hinder multi-lineage differentiation of MSCs. In contrast to these findings, exposure of MSCs to soluble factors from biofilms resulted in significant increases in the release of paracrine factors involved in inflammation and wound healing.
Conclusions: Collectively, these findings demonstrate that factors produced by biofilms can negatively impact the intrinsic properties of MSCs, in particular limiting the migratory and differentiation capacity of MSCs. Consequently, these studies suggest use/application of stem-cell therapies in the context of infection may have a limited therapeutic effect.
C1 [Ward, Catherine L.; Sanchez, Carlos J., Jr.; Pollot, Beth E.; Romano, Desiree R.; Hardy, Sharanda K.; Becerra, Sandra C.; Rathbone, Christopher R.; Wenke, Joseph C.] US Army, Inst Surg Res, Dept Extrem Trauma & Regenerat Med, San Antonio, TX 78234 USA.
RP Ward, CL (reprint author), US Army, Inst Surg Res, Dept Extrem Trauma & Regenerat Med, San Antonio, TX 78234 USA.
EM catherine.l.ward.vol@mail.mil
FU Combat Casualty Care Research Program, Medical Research and Materiel
Command; Post-doctoral Research Associate Fellowship through the
National Academy of Sciences
FX This work was supported by intramural funding from the Combat Casualty
Care Research Program, Medical Research and Materiel Command to JCW. CLW
and CJS are supported by a Post-doctoral Research Associate Fellowship
through the National Academy of Sciences.
NR 58
TC 8
Z9 8
U1 1
U2 14
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1471-2180
J9 BMC MICROBIOL
JI BMC Microbiol.
PD MAR 28
PY 2015
VL 15
AR 75
DI 10.1186/s12866-015-0412-x
PG 14
WC Microbiology
SC Microbiology
GA CE5VW
UT WOS:000351904800001
PM 25886581
ER
PT J
AU Akber, A
Reed, MW
Walker, PM
Litvinov, YA
Lane, GJ
Kibedi, T
Blaum, K
Bosch, F
Brandau, C
Carroll, JJ
Cullen, DM
Cullen, IJ
Deo, AY
Detwiler, B
Dimopoulou, C
Dracoulis, GD
Farinon, F
Geissel, H
Haettner, E
Heil, M
Kempley, RS
Knobel, R
Kozhuharov, C
Kurcewicz, J
Kuzminchuk, N
Litvinov, S
Liu, Z
Mao, R
Nociforo, C
Nolden, F
Plass, WR
Podolyak, Z
Prochazka, A
Scheidenberger, C
Shubina, D
Steck, M
Stohlker, T
Sun, B
Swan, TPD
Trees, G
Weick, H
Winckler, N
Winkler, M
Woods, PJ
Yamaguchi, T
AF Akber, A.
Reed, M. W.
Walker, P. M.
Litvinov, Yu. A.
Lane, G. J.
Kibedi, T.
Blaum, K.
Bosch, F.
Brandau, C.
Carroll, J. J.
Cullen, D. M.
Cullen, I. J.
Deo, A. Y.
Detwiler, B.
Dimopoulou, C.
Dracoulis, G. D.
Farinon, F.
Geissel, H.
Haettner, E.
Heil, M.
Kempley, R. S.
Knoebel, R.
Kozhuharov, C.
Kurcewicz, J.
Kuzminchuk, N.
Litvinov, S.
Liu, Z.
Mao, R.
Nociforo, C.
Nolden, F.
Plass, W. R.
Podolyak, Zs.
Prochazka, A.
Scheidenberger, C.
Shubina, D.
Steck, M.
Stoehlker, Th.
Sun, B.
Swan, T. P. D.
Trees, G.
Weick, H.
Winckler, N.
Winkler, M.
Woods, P. J.
Yamaguchi, T.
TI Increased isomeric lifetime of hydrogen-like Os-192m
SO PHYSICAL REVIEW C
LA English
DT Article
ID SCHOTTKY MASS-SPECTROMETRY; HEAVY-ION STORAGE; CONVERSION COEFFICIENTS;
COOLER RING; ESR; DEPENDENCE; NUCLEI; TRAPS; STATE; FRS
AB An excited metastable nuclear state of Os-192 in a hydrogen-like charge state has been studied for the first time. It was populated in projectile fragmentation of a Au-197 beam on a Be-9 target with the UNILAC-SIS accelerators at GSI. Fragmentation products in the region of interest were passed through the fragment separator and injected into the experimental storage ring (ESR). Cooling of the injected beam particles enabled Schottky mass spectrometry to be performed. Analysis shows the lifetime of the state to be considerably longer than that of the neutral ion [tau(neut) = 8.5(14) s]; this change is attributed to hindrance of internal conversion in hydrogen-like Os-192. Calculations have been performed to estimate the lifetime, and the result has been compared with that measured experimentally. There is good agreement between the expected [tau(H-like) = 13.0(24) s] and measured lifetimes (tau(rest) = 15.1(-1.3)(+1.5) s) from the internal decay of Os-192m. This provides a test for the reliability of the values obtained from internal conversion coefficient calculations in highly ionized systems and is the first measurement of its kind to be performed using the ESR setup.
C1 [Akber, A.; Reed, M. W.; Lane, G. J.; Kibedi, T.; Dracoulis, G. D.] Australian Natl Univ, Dept Nucl Phys, RSPE, Canberra, ACT 0200, Australia.
[Walker, P. M.; Cullen, I. J.; Deo, A. Y.; Kempley, R. S.; Podolyak, Zs.; Swan, T. P. D.] Univ Surrey, Dept Phys, Guildford GU2 7XH, Surrey, England.
[Litvinov, Yu. A.; Blaum, K.; Shubina, D.; Winckler, N.] Max Planck Inst Kernphys, D-69117 Heidelberg, Germany.
[Litvinov, Yu. A.; Bosch, F.; Dimopoulou, C.; Farinon, F.; Geissel, H.; Heil, M.; Knoebel, R.; Kozhuharov, C.; Kurcewicz, J.; Kuzminchuk, N.; Litvinov, S.; Nociforo, C.; Nolden, F.; Plass, W. R.; Prochazka, A.; Scheidenberger, C.; Steck, M.; Stoehlker, Th.; Weick, H.; Winckler, N.; Winkler, M.] GSI Helmholtzzentrum Schwerionenforsch, D-64291 Darmstadt, Germany.
[Brandau, C.] ExtreMe Matter Inst EMMI, D-64291 Darmstadt, Germany.
[Brandau, C.] GSI Helmholtzzentrum Schwerionenforsch, Div Res, D-64291 Darmstadt, Germany.
[Brandau, C.] Univ Giessen, Inst Atom & Mol Phys, D-35392 Giessen, Germany.
[Carroll, J. J.] US Army Res Lab, Adelphi, MD 20783 USA.
[Cullen, D. M.] Univ Manchester, Sch Phys & Astron, Schuster Lab, Manchester M13 9PL, Lancs, England.
[Detwiler, B.; Trees, G.] Youngstown State Univ, Youngstown, OH 44555 USA.
[Geissel, H.; Haettner, E.; Plass, W. R.; Scheidenberger, C.] Univ Giessen, Inst Phys 2, D-35392 Giessen, Germany.
[Liu, Z.; Woods, P. J.] Univ Edinburgh, Sch Phys & Astron, Edinburgh EH9 3JZ, Midlothian, Scotland.
[Mao, R.] Chinese Acad Sci, Inst Modern Phys, Lanzhou 730000, Peoples R China.
[Stoehlker, Th.] Heidelberg Univ, Inst Phys, D-69120 Heidelberg, Germany.
[Sun, B.] Beihaug Univ, Sch Phys & Nucl Energy Engn, Beijing 100191, Peoples R China.
[Yamaguchi, T.] Saitama Univ, Grad Sch Sci & Engn, Saitama 3388570, Japan.
RP Akber, A (reprint author), Australian Natl Univ, Dept Nucl Phys, RSPE, GPO Box 4, Canberra, ACT 0200, Australia.
RI Lane, Gregory/A-7570-2011; Sun, Baohua/C-6823-2009
OI Lane, Gregory/0000-0003-2244-182X; Sun, Baohua/0000-0001-9868-5711
FU UK STFC, DTRA(YSU) [HDTRA1-08-1-0014]; Australian Research Council
[FT10010099]; BMBF [06GI911I, 06GI7127/05P12R6FAN]; Helmholtz Alliance
[HA216/EMMI]; international Max Planck Research School for Precision
Test of Fundamental Symmetries at MPIK; NECT; NSFC [11105010]; BMBF
Grant in the framework of the Internationale Zusammenarbeit in Bildung
und Forschung; Helmholtz/CAS Joint Research Group HCJRG [HCJRG-108];
Japan Society for the Promotion of Science [A19204023]; [WTZ 01DO12012]
FX The authors are grateful to the accelerator team for their excellent
contribution. This work has been supported by the UK STFC, DTRA(YSU)
under Contract No. HDTRA1-08-1-0014, and the Australian Research Council
(Grant No. FT10010099). C. Brandau was supported by BMBF (Contract
06GI911I and 06GI7127/05P12R6FAN) and by the Helmholtz Alliance
HA216/EMMI. D. Shubina is supported by the international Max Planck
Research School for Precision Test of Fundamental Symmetries at MPIK. B.
Sun is partially supported by NECT and NSFC 11105010 and by the BMBF
Grant in the framework of the Internationale Zusammenarbeit in Bildung
und Forschung. Yu. A. Litvinov was supported by WTZ 01DO12012 and
Helmholtz/CAS Joint Research Group HCJRG (Group No. HCJRG-108). T.
Yamaguchi is grateful for a grant-in-aid for scientific research No.
A19204023 by the Japan Society for the Promotion of Science.
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PU AMER PHYSICAL SOC
PI COLLEGE PK
PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA
SN 2469-9985
EI 2469-9993
J9 PHYS REV C
JI Phys. Rev. C
PD MAR 27
PY 2015
VL 91
IS 3
AR 031301
DI 10.1103/PhysRevC.91.031301
PG 4
WC Physics, Nuclear
SC Physics
GA CE3NL
UT WOS:000351733200001
ER
PT J
AU Masters, BC
Garvin, TP
Mitsingas, CM
Ford, KB
Marsh, CP
AF Masters, B. C.
Garvin, T. P.
Mitsingas, C. M.
Ford, K. B.
Marsh, C. P.
TI Design and manufacture of a microchannel plasma reactor by CNC milling
SO MICROELECTRONIC ENGINEERING
LA English
DT Article
DE Plasma discharge; Microchannel; Microfluidics; Micro milling
ID MICROPLASMA; DEVICES; BENDS; FLOW
AB Microcavity plasma devices show promise for controlled plasma chemistry. However, these devices are typically made through processes that are difficult to scale up. We present the design and characterization of a microchannel system suitable for the study of microplasmas. The channel was created with a micro-mill CNC machine that allows for quick device manufacturing. The channel is characterized using scanning electron microscopy and profilometry. Finally, we use recently published models of flow in a microchannel with bends to elucidate pressure conditions throughout the channel. Future work will encompass characterization of plasma conditions. (C) 2015 Published by Elsevier B.V.
C1 [Masters, B. C.; Mitsingas, C. M.; Ford, K. B.; Marsh, C. P.] US Army Corps Engineers, Engn Res & Dev Ctr, Construct Engn Res Lab, Champaign, IL 61822 USA.
[Garvin, T. P.] Univ Illinois, Dept Mech Sci & Engn, Urbana, IL 61801 USA.
[Masters, B. C.; Marsh, C. P.] Univ Illinois, Dept Nucl Plasma & Radiol Engn, Urbana, IL 61801 USA.
RP Masters, BC (reprint author), US Army Corps Engineers, Engn Res & Dev Ctr, Construct Engn Res Lab, 2902 Newmark Dr, Champaign, IL 61822 USA.
EM bcmaster@illinois.edu
FU Army Corps of Engineers through US Army Research, Development, Test &
Evaluation (RDT&E) Program Element [T23]; Basic Research/Military
Construction [10-55]; Fundamental Investigation of Microplasma Gas
Reactions at Atmospheric Pressures
FX The authors would like to thank Professor S. G. Kapoor (Department of
MechSE, University of Illinois) for allowing the use of the micro CNC
machine. This investigation was funded by the Army Corps of Engineers
through US Army Research, Development, Test & Evaluation (RDT&E) Program
Element T23, "Basic Research/Military Construction"; Project 10-55,
"Fundamental Investigation of Microplasma Gas Reactions at Atmospheric
Pressures." This research was supported in part by an appointment to the
Postgraduate Research Participation Program at the US Army Engineer
Research and Development Center, Construction Engineering Research
Laboratory, administered by the Oak Ridge Institute for Science and
Education (ORISE) through an interagency agreement between the US
Department of Energy and US Army ERDC-CERL. This work was carried out in
part in the Frederick Seitz Materials Research Laboratory Central
Research Facilities, University of Illinois at Urbana-Champaign.
NR 13
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PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0167-9317
EI 1873-5568
J9 MICROELECTRON ENG
JI Microelectron. Eng.
PD MAR 25
PY 2015
VL 136
BP 51
EP 56
DI 10.1016/j.mee.2015.03.052
PG 6
WC Engineering, Electrical & Electronic; Nanoscience & Nanotechnology;
Optics; Physics, Applied
SC Engineering; Science & Technology - Other Topics; Optics; Physics
GA CI8LI
UT WOS:000355023400010
ER
PT J
AU Lai, LL
Davey, R
Beck, A
Xu, YX
Suffredini, AF
Palmore, T
Kabbani, S
Rogers, S
Kobinger, G
Alimonti, J
Link, CJ
Rubinson, L
Stroher, U
Wolcott, M
Dorman, W
Uyeki, TM
Feldmann, H
Lane, HC
Mulligan, MJ
AF Lai, Lilin
Davey, Richard
Beck, Allison
Xu, Yongxian
Suffredini, Anthony F.
Palmore, Tara
Kabbani, Sarah
Rogers, Susan
Kobinger, Gary
Alimonti, Judie
Link, Charles J., Jr.
Rubinson, Lewis
Stroeher, Ute
Wolcott, Mark
Dorman, William
Uyeki, Timothy M.
Feldmann, Heinz
Lane, H. Clifford
Mulligan, Mark J.
TI Emergency Postexposure Vaccination With Vesicular Stomatitis
Virus-Vectored Ebola Vaccine After Needlestick
SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
LA English
DT Article
ID NONHUMAN-PRIMATES; MONOCLONAL-ANTIBODIES; PROTECTION; INFECTION; FEVER
AB IMPORTANCE Safe and effective vaccines and drugs are needed for the prevention and treatment of Ebola virus disease, including following a potentially high-risk exposure such as a needlestick.
OBJECTIVE To assess response to postexposure vaccination in a health care worker who was exposed to the Ebola virus.
DESIGN AND SETTING Case report of a physician who experienced a needlestick while working in an Ebola treatment unit in Sierra Leone on September 26, 2014. Medical evacuation to the United States was rapidly initiated. Given the concern about potentially lethal Ebola virus disease, the patient was offered, and provided his consent for, postexposure vaccination with an experimental vaccine available through an emergency Investigational New Drug application. He was vaccinated on September 28, 2014.
INTERVENTIONS The vaccine used was VSV Delta G-ZEBOV, a replicating, attenuated, recombinant vesicular stomatitis virus (serotype Indiana) whose surface glycoprotein gene was replaced by the Zaire Ebola virus glycoprotein gene. This vaccine has entered a clinical trial for the prevention of Ebola in West Africa.
RESULTS The vaccine was administered 43 hours after the needlestick occurred. Fever and moderate to severe symptoms developed 12 hours after vaccination and diminished over 3 to 4 days. The real-time reverse transcription polymerase chain reaction results were transiently positive for vesicular stomatitis virus nucleoprotein gene and Ebola virus glycoprotein gene (both included in the vaccine) but consistently negative for Ebola virus nucleoprotein gene (not in the vaccine). Early postvaccination cytokine secretion and T lymphocyte and plasmablast activation were detected. Subsequently, Ebola virus glycoprotein-specific antibodies and T cells became detectable, but antibodies against Ebola viral matrix protein 40 (not in the vaccine) were not detected.
CONCLUSIONS AND RELEVANCE It is unknown if VSV Delta G-ZEBOV is safe or effective for postexposure vaccination in humans who have experienced a high-risk occupational exposure to the Ebola virus, such as a needlestick. In this patient, postexposure vaccination with VSV Delta G-ZEBOV induced a self-limited febrile syndrome that was associated with transient detection of the recombinant vesicular stomatitis vaccine virus in blood. Strong innate and Ebola-specific adaptive immune responses were detected after vaccination. The clinical syndrome and laboratory evidence were consistent with vaccination response, and no evidence of Ebola virus infection was detected.
C1 [Lai, Lilin; Beck, Allison; Xu, Yongxian; Kabbani, Sarah; Rogers, Susan; Mulligan, Mark J.] Emory Univ, Sch Med, Dept Med, Emory Vaccine Ctr,Div Infect Dis,Hope Clin, Atlanta, GA USA.
[Davey, Richard; Suffredini, Anthony F.; Palmore, Tara; Lane, H. Clifford] NIAID, Div Clin Res, Ctr Clin, NIH, Bethesda, MD 20892 USA.
[Kobinger, Gary; Alimonti, Judie] Publ Hlth Agcy Canada, Natl Lab Zoonot Dis & Special Pathogens, Winnipeg, MB, Canada.
[Link, Charles J., Jr.] NewLink Genet Corp, Ames, IA USA.
[Rubinson, Lewis] Univ Maryland, Sch Med, Div Trauma Crit Care, R Adams Cowley Shock Trauma Ctr, Baltimore, MD 21201 USA.
[Stroeher, Ute; Uyeki, Timothy M.] US Ctr Dis Control & Prevent, Atlanta, GA USA.
[Wolcott, Mark; Dorman, William] US Army, Diagnost Syst Div, Med Res Inst Infect Dis, Frederick, MD USA.
[Feldmann, Heinz] NIAID, Div Intramural Res, Virol Lab, NIH, Hamilton, MT USA.
RP Mulligan, MJ (reprint author), Emory Univ, Hope Clin, Emory Vaccine Ctr, 500 Irvin Ct,Ste 200, Decatur, GA 30030 USA.
EM mark.mulligan@emory.edu
FU Georgia Research Alliance and Emory University; National Center for
Advancing Translational Sciences of the National Institutes of Health
[UL1TR000454]; Emory Vaccinology Training Program under the National
Institute of Allergy and Infectious Diseases, National Institutes of
Health [T32AI074492]; National Institute of Allergy and Infectious
Diseases Intramural Research Program at the National Institutes of
Health
FX This work was supported in part by the Georgia Research Alliance and
Emory University (Dr Mulligan); the National Center for Advancing
Translational Sciences of the National Institutes of Health (award
UL1TR000454); the Emory Vaccinology Training Program under the National
Institute of Allergy and Infectious Diseases, National Institutes of
Health (T32AI074492 awarded to Drs Kabbani and Mulligan); and the
National Institute of Allergy and Infectious Diseases Intramural
Research Program at the National Institutes of Health.
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PU AMER MEDICAL ASSOC
PI CHICAGO
PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA
SN 0098-7484
EI 1538-3598
J9 JAMA-J AM MED ASSOC
JI JAMA-J. Am. Med. Assoc.
PD MAR 24
PY 2015
VL 313
IS 12
BP 1249
EP 1255
DI 10.1001/jama.2015.1995
PG 7
WC Medicine, General & Internal
SC General & Internal Medicine
GA CD9RJ
UT WOS:000351435500024
PM 25742465
ER
PT J
AU Collier, ZA
Kennedy, AJ
Poda, AR
Cuddy, MF
Moser, RD
MacCuspie, RI
Harmon, A
Plourde, K
Haines, CD
Steevens, JA
AF Collier, Zachary A.
Kennedy, Alan J.
Poda, Aimee R.
Cuddy, Michael F.
Moser, Robert D.
MacCuspie, Robert I.
Harmon, Ashley
Plourde, Kenton
Haines, Christopher D.
Steevens, Jeffery A.
TI Tiered guidance for risk-informed environmental health and safety
testing of nanotechnologies
SO JOURNAL OF NANOPARTICLE RESEARCH
LA English
DT Article
DE Nano; Environmental health and safety; Release; Hazard; Risk; Regulatory
ID ECOTOXICITY TEST METHODS; SILVER NANOPARTICLES; DAPHNIA-MAGNA;
SURFACE-AREA; CATEGORIZATION FRAMEWORK; ENGINEERED NANOMATERIALS;
CONSUMER PRODUCTS; AQUATIC ORGANISMS; CARBON NANOTUBES; OXIDATIVE STRESS
AB Provided the rapid emergence of novel technologies containing engineered nanomaterials, there is a need to better understand the potential environmental, health, and safety effects of nanotechnologies before wide-scale deployment. However, the unique properties of nanomaterials and uncertainty regarding applicable test methods have led to a lack of consensus regarding the collection and evaluation of data related to hazard and exposure potentials. Often, overly conservative approaches to characterization and data collection result in prolonged, unfocused, or irrelevant testing, which increases costs and delays deployment. In this paper, we provide a novel testing guidance framework for determining whether a nanotechnology has the potential to release material with nano-specific parameters that pose a risk to humans or the environment. The framework considers methods to categorize nanotechnologies by their structure and within their relevant-use scenarios to inform testing in a time-and resource-limited reality. Based on the precedent of dredged sediment testing, a five-tiered approach is proposed in which opportunities are presented to conclude testing once sufficient risk-related information has been collected, or that the technology in question does not require nano-specific scrutiny. A series of screening stages are suggested, covering relevant aspects including size, surface area, distribution, unique behaviors, and release potential. The tiered, adaptive guidance approach allows users to concentrate on collecting the most relevant data, thus accelerating technology deployment while minimizing risk.
C1 [Collier, Zachary A.; Kennedy, Alan J.; Poda, Aimee R.; Cuddy, Michael F.; Moser, Robert D.; Harmon, Ashley; Plourde, Kenton; Steevens, Jeffery A.] US Army Engn Res & Dev Ctr, Vicksburg, MS 39180 USA.
[MacCuspie, Robert I.] Florida Polytech Univ, Lakeland, FL 33805 USA.
[Haines, Christopher D.] US Army Armament Res Dev & Engn Ctr, Picatinny Arsenal, NJ 07806 USA.
RP Kennedy, AJ (reprint author), US Army Engn Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA.
EM alan.j.kennedy@usace.army.mil
RI Poda, Aimee/K-1905-2012
FU Army Environmental Quality and Installations (EQI) Technology Research
Program
FX Permission was granted by the US Army Corps of Engineers, Chief of
Engineers to publish this material. The views expressed in this article
are solely those of the authors and do not reflect the official policies
or positions of the Department of Army, the Department of Defense, or
any other department or agency of the U.S. government. Mention of trade
names or commercial products does not constitute endorsement or
recommendation for use. This work was funded through the Army
Environmental Quality and Installations (EQI) Technology Research
Program (Dr. Elizabeth Ferguson, Technical Director) for the U.S Army
Engineer Research and Development Center (ERDC).
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PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 1388-0764
EI 1572-896X
J9 J NANOPART RES
JI J. Nanopart. Res.
PD MAR 21
PY 2015
VL 17
IS 3
AR 155
DI 10.1007/s11051-015-2943-3
PG 21
WC Chemistry, Multidisciplinary; Nanoscience & Nanotechnology; Materials
Science, Multidisciplinary
SC Chemistry; Science & Technology - Other Topics; Materials Science
GA CI8JE
UT WOS:000355017800001
ER
PT J
AU Guo, W
Kirste, R
Bryan, Z
Bryan, I
Gerhold, M
Collazo, R
Sitar, Z
AF Guo, Wei
Kirste, Ronny
Bryan, Zachary
Bryan, Isaac
Gerhold, Michael
Collazo, Ramon
Sitar, Zlatko
TI Nanostructure surface patterning of GaN thin films and application to
AlGaN/AlN multiple quantum wells: A way towards light extraction
efficiency enhancement of III-nitride based light emitting diodes
SO JOURNAL OF APPLIED PHYSICS
LA English
DT Article
ID ANODIC POROUS ALUMINA; PHOTONIC CRYSTAL; GROWTH; LEDS; ALN
AB Enhanced light extraction efficiency was demonstrated on nanostructure patterned GaN and AlGaN/AlN Multiple-Quantum-Well (MQW) structures using mass production techniques including natural lithography and interference lithography with feature size as small as 100 nm. Periodic nanostructures showed higher light extraction efficiency and modified emission profile compared to non-periodic structures based on integral reflection and angular-resolved transmission measurement. Light extraction mechanism of macroscopic and microscopic nanopatterning is discussed, and the advantage of using periodic nanostructure patterning is provided. An enhanced photoluminescence emission intensity was observed on nanostructure patterned AlGaN/AlN MQW compared to as-grown structure, demonstrating a large-scale and mass-producible pathway to higher light extraction efficiency in deep-ultra-violet light-emitting diodes. (C) 2015 AIP Publishing LLC.
C1 [Guo, Wei; Kirste, Ronny; Bryan, Zachary; Bryan, Isaac; Collazo, Ramon; Sitar, Zlatko] N Carolina State Univ, Dept Mat Sci & Engn, Raleigh, NC 27695 USA.
[Gerhold, Michael] Army Res Off, Engn Sci Directorate, Res Triangle Pk, NC 27703 USA.
RP Guo, W (reprint author), N Carolina State Univ, Dept Mat Sci & Engn, Box 7907, Raleigh, NC 27695 USA.
EM wguo2@ncsu.edu
FU NSF [DMR-1108071, DMR-1312582]; ARO [W911NF-04-D-0003]; ARL
[W911QX-10-C-0027]
FX The authors would like to acknowledge partial financial support from the
NSF (DMR-1108071 and DMR-1312582), ARO (W911NF-04-D-0003), and ARL
(W911QX-10-C-0027). The authors would like to thank Dr. Jinqiao Xie of
HexaTech (currently at TriQuint Semiconductor) for initial fruitful
discussions. All of the AlN wafers used for growth of MQWs were supplied
by HexaTech, Inc., Morrisville, North Carolina, www.hexatechinc.com.
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PU AMER INST PHYSICS
PI MELVILLE
PA 1305 WALT WHITMAN RD, STE 300, MELVILLE, NY 11747-4501 USA
SN 0021-8979
EI 1089-7550
J9 J APPL PHYS
JI J. Appl. Phys.
PD MAR 21
PY 2015
VL 117
IS 11
AR 113107
DI 10.1063/1.4915903
PG 8
WC Physics, Applied
SC Physics
GA CE1WZ
UT WOS:000351604900022
ER
PT J
AU Engler, RJM
Nelson, MR
Collins, LC
Spooner, C
Hemann, BA
Gibbs, BT
Atwood, JE
Howard, RS
Chang, AS
Cruser, DL
Gates, DG
Vernalis, MN
Lengkeek, MS
McClenathan, BM
Jaffe, AS
Cooper, LT
Black, S
Carlson, C
Wilson, C
Davis, RL
AF Engler, Renata J. M.
Nelson, Michael R.
Collins, Limone C., Jr.
Spooner, Christina
Hemann, Brian A.
Gibbs, Barnett T.
Atwood, J. Edwin
Howard, Robin S.
Chang, Audrey S.
Cruser, Daniel L.
Gates, Daniel G.
Vernalis, Marina N.
Lengkeek, Marguerite S.
McClenathan, Bruce M.
Jaffe, Allan S.
Cooper, Leslie T.
Black, Steve
Carlson, Christopher
Wilson, Christopher
Davis, Robert L.
TI A Prospective Study of the Incidence of Myocarditis/Pericarditis and New
Onset Cardiac Symptoms following Smallpox and Influenza Vaccination
SO PLOS ONE
LA English
DT Article
ID INDUCED MYOCARDIAL-ISCHEMIA; LONG-TERM MORTALITY; TROPONIN-T; ADVERSE
EVENTS; UNITED-STATES; GENERAL-POPULATION; RISK; ELEVATION; EXERCISE;
RECOMMENDATIONS
AB Background
Although myocarditis/pericarditis (MP) has been identified as an adverse event following smallpox vaccine (SPX), the prospective incidence of this reaction and new onset cardiac symptoms, including possible subclinical injury, has not been prospectively defined.
Purpose
The study's primary objective was to determine the prospective incidence of new onset cardiac symptoms, clinical and possible subclinical MP in temporal association with immunization.
Methods
New onset cardiac symptoms, clinical MP and cardiac specific troponin T (cTnT) elevations following SPX (above individual baseline values) were measured in a multi-center prospective, active surveillance cohort study of healthy subjects receiving either smallpox vaccine or trivalent influenza vaccine (TIV).
Results
New onset chest pain, dyspnea, and/or palpitations occurred in 10.6% of SPX-vaccinees and 2.6% of TIV-vaccinees within 30 days of immunization (relative risk (RR) 4.0, 95% CI: 1.7-9.3). Among the 1081 SPX-vaccinees with complete follow-up, 4 Caucasian males were diagnosed with probable myocarditis and 1 female with suspected pericarditis. This indicates a post-SPX incidence rate more than 200-times higher than the pre-SPX background population surveillance rate of myocarditis/pericarditis (RR 214, 95% CI 65-558). Additionally, 31 SPX-vaccinees without specific cardiac symptoms were found to have over 2-fold increases in cTnT (>99th percentile) from baseline (pre-SPX) during the window of risk for clinical myocarditis/pericarditis and meeting a proposed case definition for possible subclinical myocarditis. This rate is 60-times higher than the incidence rate of overt clinical cases. No clinical or possible subclinical myocarditis cases were identified in the TIV-vaccinated group.
Conclusions
Passive surveillance significantly underestimates the true incidence of myocarditis/pericarditis after smallpox immunization. Evidence of subclinical transient cardiac muscle injury post-vaccinia immunization is a finding that requires further study to include long-term outcomes surveillance. Active safety surveillance is needed to identify adverse events that are not well understood or previously recognized.
C1 [Engler, Renata J. M.; Collins, Limone C., Jr.; Spooner, Christina] Walter Reed Natl Mil Med Ctr, Immunizat Healthcare Branch, Def Hlth Agcy, Mil Vaccine Agcy Vaccine Healthcare Ctr Network, Bethesda, MD 20889 USA.
[Engler, Renata J. M.; Nelson, Michael R.] Uniformed Serv Univ Hlth Sci, Dept Med & Pediat, Bethesda, MD 20814 USA.
[Nelson, Michael R.] Walter Reed Natl Mil Med Ctr, Allergy Immunol Immunizat, Bethesda, MD USA.
[Hemann, Brian A.; Gibbs, Barnett T.; Atwood, J. Edwin] Walter Reed Natl Mil Med Ctr, Dept Med, Serv Cardiol, Bethesda, MD USA.
[Hemann, Brian A.; Gibbs, Barnett T.; Atwood, J. Edwin] Uniformed Serv Univ Hlth Sci, Dept Med, Bethesda, MD 20814 USA.
[Howard, Robin S.; Chang, Audrey S.] Walter Reed Natl Mil Med Ctr, Dept Res Programs, Bethesda, MD USA.
[Cruser, Daniel L.] Vassar Bros Med Ctr, Dept Pathol, Poughkeepsie, NY USA.
[Gates, Daniel G.] Ft Belvoir Community Hosp, Serv Cardiol, Ft Belvoir, VA USA.
[Vernalis, Marina N.] Walter Reed Natl Mil Med Ctr, Integrated Cardiac Hlth Project, Bethesda, MD USA.
[Lengkeek, Marguerite S.] Allergy & Asthma Care Ctr, Chantilly, VA USA.
[McClenathan, Bruce M.] Womack Army Med Ctr, Def Hlth Agcy, Immunizat Healthcare Branch, Mil Vaccine Agcy Vaccine Healthcare Ctr Network, Ft Bragg, NC USA.
[Jaffe, Allan S.; Cooper, Leslie T.] Mayo Clin, Div Cardiovasc Dis, Rochester, MN USA.
[Black, Steve] Cincinnati Childrens Hosp Ctr Global Hlth, Cincinnati, OH USA.
[Carlson, Christopher] Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Seattle, WA 98104 USA.
[Wilson, Christopher] Univ Washington, Dept Immunol, Seattle, WA 98195 USA.
[Davis, Robert L.] Univ Tennessee, Ctr Hlth Sci, Ctr Biomed Informat, Memphis, TN 38163 USA.
[Davis, Robert L.] Oak Ridge Natl Lab, Oak Ridge, TN USA.
RP Engler, RJM (reprint author), Walter Reed Natl Mil Med Ctr, Immunizat Healthcare Branch, Def Hlth Agcy, Mil Vaccine Agcy Vaccine Healthcare Ctr Network, Bethesda, MD 20889 USA.
EM renata.engler@gmail.com
FU Centers for Disease Control and Prevention [200-2002-00732]; National
Institute of Allergy and Infectious Disease Population Genetics Program
[N01 AI40069]; Federal funds from the National Institute of Allergies
and Infectious Diseases, National Institutes of Health, Department of
Health and Human Services [HHSN272201000024C]
FX This study was supported by the Vaccine Healthcare Centers Network and
Allergy-Immunology, Walter Reed Army Medical Center (Bethesda,
MD)/Military Vaccine Agency, Office of the Army Surgeon General,
Clinical Immunization Safety Assessment Network (Atlanta, GA)
(subcontract with America's Health Insurance Plans under contract
200-2002-00732 from the Centers for Disease Control and Prevention),
National Institute of Allergy and Infectious Disease Population Genetics
Program (N01 AI40069). This project has been funded in part with Federal
funds from the National Institute of Allergies and Infectious Diseases,
National Institutes of Health, Department of Health and Human Services,
under Contract No. HHSN272201000024C. The funders had no role in study
design, data collection and analysis, decision to publish, or
preparation of the manuscript.
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U1 0
U2 6
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD MAR 20
PY 2015
VL 10
IS 3
AR e0118283
DI 10.1371/journal.pone.0118283
PG 18
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA CE8IA
UT WOS:000352084200018
PM 25793705
ER
PT J
AU Warfield, KL
Dye, JM
Wells, JB
Unfer, RC
Holtsberg, FW
Shulenin, S
Vu, H
Swenson, DL
Bavari, S
Aman, MJ
AF Warfield, Kelly L.
Dye, John M.
Wells, Jay B.
Unfer, Robert C.
Holtsberg, Frederick W.
Shulenin, Sergey
Vu, Hong
Swenson, Dana L.
Bavari, Sina
Aman, M. Javad
TI Homologous and Heterologous Protection of Nonhuman Primates by Ebola and
Sudan Virus-Like Particles
SO PLOS ONE
LA English
DT Article
ID MARBURG VIRUSES; INSECT CELLS; GUINEA-PIGS; INFECTION; VACCINE;
CHALLENGE; ANTIBODIES; IMMUNIZATION; RESPONSES; MUCOSAL
AB Filoviruses cause hemorrhagic fever resulting in significant morbidity and mortality in humans. Several vaccine platforms that include multiple virus-vectored approaches and virus-like particles (VLPs) have shown efficacy in nonhuman primates. Previous studies have shown protection of cynomolgus macaques against homologous infection for Ebola virus (EBOV) and Marburg virus (MARV) following a three-dose vaccine regimen of EBOV or MARV VLPs, as well as heterologous protection against Ravn Virus (RAVV) following vaccination with MARV VLPs. The objectives of the current studies were to determine the minimum number of vaccine doses required for protection (using EBOV as the test system) and then demonstrate protection against Sudan virus (SUDV) and Tai Forest virus (TAFV). Using the EBOV nonhuman primate model, we show that one or two doses of VLP vaccine can confer protection from lethal infection. VLPs containing the SUDV glycoprotein, nucleoprotein and VP40 matrix protein provide complete protection against lethal SUDV infection in macaques. Finally, we demonstrate protective efficacy mediated by EBOV, but not SUDV, VLPs against TAFV; this is the first demonstration of complete cross-filovirus protection using a single component heterologous vaccine within the Ebolavirus genus. Along with our previous results, this observation provides strong evidence that it will be possible to develop and administer a broad-spectrum VLP-based vaccine that will protect against multiple filoviruses by combining only three EBOV, SUDV and MARV components.
C1 [Warfield, Kelly L.; Unfer, Robert C.; Holtsberg, Frederick W.; Shulenin, Sergey; Vu, Hong; Aman, M. Javad] Integrated Biotherapeut Inc, Gaithersburg, MD USA.
[Dye, John M.; Wells, Jay B.; Swenson, Dana L.; Bavari, Sina] US Army Med Res Inst Infect Dis, Ft Detrick, MD USA.
RP Warfield, KL (reprint author), Unither Virol LLC, Silver Spring, MD 20910 USA.
EM kwarfield@unithervirology.com
FU Federal funds from the National Institute of Allergy and Infectious
Diseases, National Institutes of Health, Department of Health and Human
Services [HHSN272200800055C]; Defense Threat Reduction Agency JSTO-CBD;
Medical Research and Material Command; Integrated Biotherapeutics
FX This project has been funded in part with Federal funds from the
National Institute of Allergy and Infectious Diseases, National
Institutes of Health, Department of Health and Human Services, under
Contract No. HHSN272200800055C to MJA (IBT) and support from the Defense
Threat Reduction Agency JSTO-CBD and the Medical Research and Material
Command to JMD and SB (USAMRIID). Integrated Biotherapeutics provided
support in the form of salaries for authors KLW, RCU, FWH, SS, HV, and
MJA but did not have any additional role in the study design, data
collection and analysis, decision to publish, or preparation of the
manuscript. The specific roles of these authors are articulated in the
'author contributions' section.
NR 42
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U1 1
U2 12
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD MAR 20
PY 2015
VL 10
IS 3
AR e0118881
DI 10.1371/journal.pone.0118881
PG 16
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA CE8IA
UT WOS:000352084200043
PM 25793502
ER
PT J
AU Amani, M
Burke, RA
Proie, RM
Dubey, M
AF Amani, Matin
Burke, Robert A.
Proie, Robert M.
Dubey, Madan
TI Flexible integrated circuits and multifunctional electronics based on
single atomic layers of MoS2 and graphene
SO NANOTECHNOLOGY
LA English
DT Article
DE flexible electronics; integrated circuits; MoS2; graphene;
heterostructures
ID FIELD-EFFECT TRANSISTORS; CHEMICAL-VAPOR-DEPOSITION; CARBON NANOTUBE;
MONOLAYER; FILMS; GROWTH
AB Two-dimensional materials, such as graphene and its analogues, have been investigated by numerous researchers for high performance flexible and conformal electronic systems, because they offer the ultimate level of thickness scaling, atomically smooth surfaces and high crystalline quality. Here, we use layer-by-layer transfer of large area molybdenum disulphide (MoS2) and graphene grown by chemical vapor deposition (CVD) to demonstrate electronics on flexible polyimide (PI) substrates. On the same PI substrate, we are able to simultaneously fabricate MoS2 based logic, non-volatile memory cells with graphene floating gates, photo-detectors and MoS2 transistors with tunable source and drain contacts. We are also able to demonstrate that these flexible heterostructure devices have very high electronic performance, comparable to four point measurements taken on SiO2 substrates, with on/off ratios > 10(7) and field effect mobilities as high as 16.4 cm(2) V-1 s(-1). Additionally, the heterojunctions show high optoelectronic sensitivity and were operated as photodetectors with responsivities over 30 AW(-1). Through local gating of the individual graphene/MoS2 contacts, we are able to tune the contact resistance over the range of 322-1210 ohm mm for each contact, by modulating the graphene work function. This leads to devices with tunable and multifunctional performance that can be implemented in a conformable platform.
C1 [Amani, Matin; Burke, Robert A.; Proie, Robert M.; Dubey, Madan] US Army, Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA.
RP Amani, M (reprint author), Univ Calif Berkeley, Elect Engn & Comp Sci, Berkeley, CA 94720 USA.
EM madan.dubey.civ@mail.mil
FU US Army Research Lab (ARL)
FX The authors acknowledge the support of the US Army Research Lab (ARL)
Director's Strategic Initiative (DSI) program on interfaces in stacked
2D atomic layered materials. The authors would also like to thank Dr
Pani Varanasi of the Army Research Office for his in-depth technical
discussion on 2D atomic layers R and D. The views and conclusions
contained in this document are those of the authors and should not be
interpreted as representing the official policies, either expressed or
implied, of the ARL or the US Government. The US Government is
authorized to reproduce or distribute reprints for Government purposes
notwithstanding any copyright notation herein.
NR 34
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U1 11
U2 194
PU IOP PUBLISHING LTD
PI BRISTOL
PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND
SN 0957-4484
EI 1361-6528
J9 NANOTECHNOLOGY
JI Nanotechnology
PD MAR 20
PY 2015
VL 26
IS 11
AR 115202
DI 10.1088/0957-4484/26/11/115202
PG 8
WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary;
Physics, Applied
SC Science & Technology - Other Topics; Materials Science; Physics
GA CC7SO
UT WOS:000350568900005
PM 25709100
ER
PT J
AU Kim, H
Wu, FX
Lee, JT
Nitta, N
Lin, HT
Oschatz, M
Cho, WI
Kaskel, S
Borodin, O
Yushin, G
AF Kim, Hyea
Wu, Feixiang
Lee, Jung Tae
Nitta, Naoki
Lin, Huan-Ting
Oschatz, Martin
Cho, Won Il
Kaskel, Stefan
Borodin, Oleg
Yushin, Gleb
TI In Situ Formation of Protective Coatings on Sulfur Cathodes in Lithium
Batteries with LiFSI-Based Organic Electrolytes
SO ADVANCED ENERGY MATERIALS
LA English
DT Article
DE dissolution; cathodes; batteries; electrolytes; protective coatings
ID LI-S BATTERIES; RECHARGEABLE BATTERIES; PERFORMANCE; CARBON; CELLS;
STABILITY; SALT; TEMPERATURE; PARTICLES; CAPACITY
AB Development of sulfur cathodes with 100% coulombic efficiency (CE) and good cycle stability remains challenging due to the polysulfide dissolution in electrolytes. Here, it is demonstrated that electrochemical reduction of lithium bis(fluorosulfonyl)imide (LiFSI) based electrolytes at a potential close to the sulfur cathode operation forms in situ protective coating on both cathode and anode surfaces. Quantum chemistry studies suggest the coating formation is initiated by the FSI(-F) anion radicals generated during electrolyte reduction. Such a reduction additionally results in the formation of LiF. Accelerated cycle stability tests at 60 degrees C in a very simple electrolyte (LiFSI in dimethoxyethane with no additives) show an average CE approaching 100.0% over 1000 cycles with a capacity decay less than 0.013% per cycle after stabilization. Such a remarkable performance suggests a great promise of both an in situ formation of protective solid electrolyte coatings to avoid unwanted side reactions and the use of a LiFSI salt for this purpose.
C1 [Kim, Hyea; Wu, Feixiang; Lee, Jung Tae; Nitta, Naoki; Lin, Huan-Ting; Yushin, Gleb] Georgia Inst Technol, Sch Mat Sci & Engn, Atlanta, GA 30332 USA.
[Kim, Hyea] Sila Nanotechnol Inc, Atlanta, GA 30332 USA.
[Wu, Feixiang] Cent S Univ, Sch Met & Environm, Changsha 410083, Hunan, Peoples R China.
[Oschatz, Martin; Kaskel, Stefan] Tech Univ Dresden, Dept Inorgan Chem, D-01069 Dresden, Germany.
[Cho, Won Il] Korea Inst Sci & Technol, Ctr Energy Convergence, Seoul 130650, South Korea.
[Borodin, Oleg] Army Res Lab, Electrochem Branch, Adelphi, MD 20783 USA.
RP Yushin, G (reprint author), Georgia Inst Technol, Sch Mat Sci & Engn, Atlanta, GA 30332 USA.
EM yushin@gatech.edu
RI Oschatz, Martin/B-1239-2015; Yushin, Gleb/B-4529-2013; Borodin,
Oleg/B-6855-2012;
OI Yushin, Gleb/0000-0002-3274-9265; Borodin, Oleg/0000-0002-9428-5291;
Kaskel, Stefan/0000-0003-4572-0303
FU US Army Research Office [W911NF-12-1-0259]; Energy Efficiency &
Resources program of the Korea Institute of Energy Technology Evaluation
and Planning (KETEP) - Korea government Ministry of Knowledge Economy
[20118510010030]; project "Nanomaterials for future generation Lithium
Sulphur batteries" ("MaLiSu")
FX Different aspects of this work were supported by the US Army Research
Office (grant W911NF-12-1-0259) and by the Energy Efficiency & Resources
program of the Korea Institute of Energy Technology Evaluation and
Planning (KETEP) funded by the Korea government Ministry of Knowledge
Economy (grant 20118510010030). The authors from Dresden University of
Technology gratefully acknowledge financial support by the project
"Nanomaterials for future generation Lithium Sulphur batteries"
("MaLiSu").
NR 40
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U1 26
U2 193
PU WILEY-V C H VERLAG GMBH
PI WEINHEIM
PA BOSCHSTRASSE 12, D-69469 WEINHEIM, GERMANY
SN 1614-6832
EI 1614-6840
J9 ADV ENERGY MATER
JI Adv. Energy Mater.
PD MAR 18
PY 2015
VL 5
IS 6
AR 1401792
DI 10.1002/aenm.201401792
PG 8
WC Chemistry, Physical; Energy & Fuels; Materials Science,
Multidisciplinary; Physics, Applied; Physics, Condensed Matter
SC Chemistry; Energy & Fuels; Materials Science; Physics
GA CE1ZZ
UT WOS:000351613200016
ER
PT J
AU Bradfute, SB
Anthony, SM
Stuthman, KS
Ayithan, N
Tailor, P
Shaia, CI
Bray, M
Ozato, K
Bavari, S
AF Bradfute, Steven B.
Anthony, Scott M.
Stuthman, Kelly S.
Ayithan, Natarajan
Tailor, Prafullakumar
Shaia, Carl I.
Bray, Mike
Ozato, Keiko
Bavari, Sina
TI Mechanisms of Immunity in Post-Exposure Vaccination against Ebola Virus
Infection
SO PLOS ONE
LA English
DT Article
ID PROTECTS NONHUMAN-PRIMATES; T-CELL RESPONSES; MARBURG HEMORRHAGIC-FEVER;
DENDRITIC CELLS; GUINEA-PIGS; CRYPTOCOCCUS-NEOFORMANS; FILOVIRUS
INFECTION; MOUSE MODEL; PATHOGENESIS; ANTIBODIES
AB Ebolaviruses can cause severe hemorrhagic fever that is characterized by rapid viral replication, coagulopathy, inflammation, and high lethality rates. Although there is no clinically proven vaccine or treatment for Ebola virus infection, a virus-like particle (VLP) vaccine is effective in mice, guinea pigs, and non-human primates when given pre-infection. In this work, we report that VLPs protect Ebola virus-infected mice when given 24 hours post-infection. Analysis of cytokine expression in serum revealed a decrease in pro-inflammatory cytokine and chemokine levels in mice given VLPs post-exposure compared to infected, untreated mice. Using knockout mice, we show that VLP-mediated post-exposure protection requires perforin, B cells, macrophages, conventional dendritic cells (cDCs), and either CD4+ or CD8+ T cells. Protection was Ebola virus-specific, as marburgvirus VLPs did not protect Ebola virus-infected mice. Increased antibody production in VLP-treated mice correlated with protection, and macrophages were required for this increased production. However, NK cells, IFN-gamma, and TNF-alpha were not required for post-exposure-mediated protection. These data suggest that a non-replicating Ebola virus vaccine can provide post-exposure protection and that the mechanisms of immune protection in this setting require both increased antibody production and generation of cytotoxic T cells.
C1 [Bradfute, Steven B.; Anthony, Scott M.; Stuthman, Kelly S.; Shaia, Carl I.; Bavari, Sina] US Army Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA.
[Ayithan, Natarajan; Ozato, Keiko] NICHHD, Lab Mol Growth Regulat, NIH, Bethesda, MD 20892 USA.
[Tailor, Prafullakumar] Natl Inst Immunol, New Delhi 110067, India.
[Bray, Mike] NIAID, Div Clin Res, NIH, Bethesda, MD 20892 USA.
RP Bavari, S (reprint author), US Army Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA.
EM sina.bavari.civ@mail.mil
FU Defense Threat Reduction Agency [1.1C003_08_RD_B]
FX This work was supported by a grant from the Defense Threat Reduction
Agency to SB (1.1C003_08_RD_B). The funders had no role in study design,
data collection and analysis, decision to publish, or preparation of the
manuscript.
NR 69
TC 3
Z9 3
U1 0
U2 15
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD MAR 18
PY 2015
VL 10
IS 3
AR UNSP e0118434
DI 10.1371/journal.pone.0118434
PG 21
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA CE9BN
UT WOS:000352138500034
PM 25785602
ER
PT J
AU Carr, W
Yarnell, AM
Ong, R
Walilko, T
Kamimori, GH
da Silva, U
McCarron, RM
LoPresti, ML
AF Carr, Walter
Yarnell, Angela M.
Ong, Ricardo
Walilko, Timothy
Kamimori, Gary H.
da Silva, Uade
McCarron, Richard M.
LoPresti, Matthew L.
TI Ubiquitin carboxy-terminal hydrolase-L1 as a serum neurotrauma biomarker
for exposure to occupational low-level blast
SO FRONTIERS IN NEUROLOGY
LA English
DT Article
DE biomarker; blast; military; neurotrauma; breacher
ID TRAUMATIC BRAIN-INJURY; NEUROPSYCHOLOGICAL ASSESSMENT METRICS;
CEREBROSPINAL-FLUID; ACUTE CONCUSSION; MILD; DISORDERS; SYMPTOMS; BLOOD;
L1
AB Repeated exposure to low-level blast is a characteristic of a few select occupations and there is concern that such occupational exposures present risk for traumatic brain injury. These occupations include specialized military and law enforcement units that employ controlled detonation of explosive charges for the purpose of tactical entry into secured structures. The concern for negative effects from blast exposure is based on rates of operator self-reported headache, sleep disturbance, working memory impairment, and other concussion-like symptoms. A challenge in research on this topic has been the need for improved assessment tools to empirically evaluate the risk associated with repeated exposure to blast overpressure levels commonly considered to be too low in magnitude to cause acute injury. Evaluation of serum-based neurotrauma biomarkers provides an objective measure that is logistically feasible for use in field training environments. Among candidate biomarkers, ubiquitin carboxy-terminal hydrolase-L1 (UCH-L1) has some empirical support and was evaluated in this study. We used daily blood draws to examine acute change in UCH-L1 among 108 healthy military personnel who were exposed to repeated low-level blast across a 2-week period. These research volunteers also wore pressure sensors to record blast exposures, wrist actigraphs to monitor sleep patterns, and completed daily behavioral assessments of symptomology, postural stability, and neurocognitive function. UCH-L1 levels were elevated as a function of participating in the 2-week training with explosives, but the correlation of UCH-L1 elevation and blast magnitude was weak and inconsistent. Also, UCH-L1 elevations did not correlate with deficits in behavioral measures. These results provide some support for including UCH-L1 as a measure of central nervous system effects from exposure to low-level blast. However, the weak relation observed suggests that additional indicators of blast effect are needed.
C1 [Carr, Walter; Yarnell, Angela M.; Kamimori, Gary H.; LoPresti, Matthew L.] Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci, Silver Spring, MD 20910 USA.
[Ong, Ricardo] US Army Special Forces Command, Ft Bragg, NC USA.
[Walilko, Timothy] Appl Res Associates Inc, Littleton, CO USA.
[da Silva, Uade; McCarron, Richard M.] Walter Reed Army Inst Res, NeuroTrauma Dept, Silver Spring, MD 20910 USA.
RP Carr, W (reprint author), Walter Reed Army Inst Res, Dept Behav Biol, Ctr Mil Psychiat & Neurosci, 503 Robert Grant Ave, Silver Spring, MD 20910 USA.
EM walter.s.carr.mil@mail.mil
FU US Army Medical Research and Materiel Command; US Navy Bureau of
Medicine; US Army Special Operations Command; US Army Engineer School
FX This work was supported by the US Army Medical Research and Materiel
Command and the US Navy Bureau of Medicine. We thank the members of the
study team who helped collect and process the data: SGT Ashlie
Strickland-Mangano, SGT Benjamin Joiner, SPC George Adams, SSG Kelly
McWhirter, SGT Shawn McLoughlin, SSG Dominic Prankienas, SGT Robert
Catalano, SGT Reginald Acklin, HM3 Eric Cho, Luke Aurich, Dan Welsh,
Brandon Peterson, Zach Gates, Stephanie Eonta, Carmen Contreras-Sesvold,
and David Miles. We also thank the leadership from the US Army Special
Operations Command and US Army Engineer School for their support and the
Soldiers of the units studied for their service to our nation and their
participation in the study.
NR 39
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U1 1
U2 2
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA PO BOX 110, EPFL INNOVATION PARK, BUILDING I, LAUSANNE, 1015,
SWITZERLAND
SN 1664-2295
J9 FRONT NEUROL
JI Front. Neurol.
PD MAR 16
PY 2015
VL 6
AR UNSP 49
DI 10.3389/fneur.2015.00049
PG 11
WC Clinical Neurology; Neurosciences
SC Neurosciences & Neurology
GA CU8CX
UT WOS:000363769900002
PM 25852633
ER
PT J
AU Morimont, P
Batchinsky, A
Lambermont, B
AF Morimont, Philippe
Batchinsky, Andriy
Lambermont, Bernard
TI Update on the role of extracorporeal CO2 removal as an adjunct to
mechanical ventilation in ARDS
SO CRITICAL CARE
LA English
DT Review
ID RESPIRATORY-DISTRESS-SYNDROME; CARBON-DIOXIDE REMOVAL; INDUCED LUNG
INJURY; POSITIVE-PRESSURE VENTILATION; TIDAL VOLUME REDUCTION;
PERMISSIVE HYPERCAPNIA; LIFE-SUPPORT; 6 ML/KG; ACIDOSIS; FAILURE
AB This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency Medicine 2015 and co-published as a series in Critical Care. Other articles in the series can be found online at http://ccforum.com/series/annualupdate2015. Further information about the Annual Update in Intensive Care and Emergency Medicine is available from http://www.springer.com/series/8901.
C1 [Morimont, Philippe; Lambermont, Bernard] Univ Hosp Liege, Dept Internal Med, Med & Coronary Intens Care Unit, Liege, Belgium.
[Batchinsky, Andriy] US Army Inst Surg Res, Battlefield Hlth & Trauma Res Inst, San Antonio, TX USA.
RP Morimont, P (reprint author), Univ Hosp Liege, Dept Internal Med, Med & Coronary Intens Care Unit, Liege, Belgium.
EM ph.morimont@chu.ulg.ac.be
FU Maquet
FX PM and BL have received supply of equipment (CO2 removal device, medical
disposables) and funding by Maquet for an experimental study on
extracorporeal CO2 removal theapy in 2013 and 2014. PM and AB have
received travel and lodging support for conferences.
NR 48
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Z9 5
U1 0
U2 1
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1466-609X
EI 1364-8535
J9 CRIT CARE
JI Crit. Care
PD MAR 16
PY 2015
VL 19
AR 117
DI 10.1186/s13054-015-0799-7
PG 7
WC Critical Care Medicine
SC General & Internal Medicine
GA CE7PE
UT WOS:000352033000001
PM 25888428
ER
PT J
AU Saguil, A
Fargo, M
Grogan, S
AF Saguil, Aaron
Fargo, Matthew
Grogan, Scott
TI Diagnosis and Management of Kawasaki Disease
SO AMERICAN FAMILY PHYSICIAN
LA English
DT Article
ID CORONARY-ARTERY ABNORMALITIES; EPIDEMIOLOGY; EFFICACY; PREVALENCE;
INFLIXIMAB; CHILDREN; THERAPY; HEALTH
AB Kawasaki disease is an acute, systemic vasculitis that predominantly affects patients younger than five years. It represents the most prominent cause of acquired coronary artery disease in childhood. In the United States, 19 per 100,000 children younger than five years are hospitalized with Kawasaki disease annually. According to U.S. and Japanese guidelines, Kawasaki disease is a clinical diagnosis. Classic (typical) Kawasaki disease is diagnosed based on the presence of a fever lasting five or more days, accompanied by four out of five findings: bilateral conjunctival injection, oral changes such as cracked and erythematous lips and strawberry tongue, cervical lymphadenopathy, extremity changes such as erythema or palm and sole desquamation, and polymorphous rash. Incomplete (atypical) Kawasaki disease occurs in persons with fever lasting five or more days and with two or three of these findings. Transthoracic echocardiography is the diagnostic imaging modality of choice to screen for coronary aneurysms, although other techniques are being evaluated for diagnosis and management. Treatment for acute disease is intravenous immunoglobulin and aspirin. If there is no response to treatment, patients are given a second dose of intravenous immunoglobulin with or without corticosteroids or other adjunctive treatments. The presence and severity of coronary aneurysms and obstruction at diagnosis determine treatment options and the need, periodicity, and intensity of long-term cardiovascular monitoring for potential atherosclerosis. Copyright (C) 2015 American Academy of Family Physicians.
C1 [Saguil, Aaron] Uniformed Serv Univ Hlth Sci, F Edward Hebert Sch Med, Recruitment & Admiss, Bethesda, MD 20814 USA.
[Fargo, Matthew] Dwight D Eisenhower Army Med Ctr, Family Med Residency Program, Ft Gordon, GA USA.
[Grogan, Scott] Dwight D Eisenhower Army Med Ctr, Family Med Residency Program, Fac Dev & Res, Ft Gordon, GA USA.
RP Saguil, A (reprint author), Dewitt Army Community Hosp, 9501 Farrell Rd, Ft Belvoir, VA 22060 USA.
EM aaron.saguil@usuhs.edu
NR 28
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Z9 1
U1 1
U2 7
PU AMER ACAD FAMILY PHYSICIANS
PI KANSAS CITY
PA 8880 WARD PARKWAY, KANSAS CITY, MO 64114-2797 USA
SN 0002-838X
EI 1532-0650
J9 AM FAM PHYSICIAN
JI Am. Fam. Physician
PD MAR 15
PY 2015
VL 91
IS 6
BP 365
EP 371
PG 7
WC Primary Health Care; Medicine, General & Internal
SC General & Internal Medicine
GA CD8GO
UT WOS:000351333400008
PM 25822554
ER
PT J
AU Gauer, RL
Semidey, MJ
AF Gauer, Robert L.
Semidey, Michael J.
TI Diagnosis and Treatment of Temporomandibular Disorders
SO AMERICAN FAMILY PHYSICIAN
LA English
DT Article
ID RANDOMIZED CONTROLLED-TRIALS; BOTULINUM-TOXIN; FACIAL-PAIN; INTERNAL
DERANGEMENT; PHYSICAL-THERAPY; CLINICAL-TRIAL; OROFACIAL PAIN; JOINT
PAIN; MANAGEMENT; ACUPUNCTURE
AB Temporomandibular disorders (TMD) are a heterogeneous group of musculoskeletal and neuromuscular conditions involving the temporomandibular joint complex, and surrounding musculature and osseous components. TMD affects up to 15% of adults, with a peak incidence at 20 to 40 years of age. TMD is classified as intra-articular or extra-articular. Common symptoms include jaw pain or dysfunction, earache, headache, and facial pain. The etiology of TMD is multifactorial and includes biologic, environmental, social, emotional, and cognitive triggers. Diagnosis is most often based on history and physical examination. Diagnostic imaging may be beneficial when malocclusion or intra-articular abnormalities are suspected. Most patients improve with a combination of noninvasive therapies, including patient education, self-care, cognitive behavior therapy, pharmacotherapy, physical therapy, and occlusal devices. Nonsteroidal anti-inflammatory drugs and muscle relaxants are recommended initially, and benzodiazepines or antidepressants may be added for chronic cases. Referral to an oral and maxillofacial surgeon is indicated for refractory cases. Copyright (C) 2015 American Academy of Family Physicians.
C1 [Gauer, Robert L.; Semidey, Michael J.] Womack Army Med Ctr, Ft Bragg, NC 28310 USA.
RP Gauer, RL (reprint author), Womack Army Med Ctr, Riley Rd,Bldg 4-2817, Ft Bragg, NC 28310 USA.
EM robertgauer@yahoo.com
NR 64
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Z9 4
U1 2
U2 14
PU AMER ACAD FAMILY PHYSICIANS
PI KANSAS CITY
PA 8880 WARD PARKWAY, KANSAS CITY, MO 64114-2797 USA
SN 0002-838X
EI 1532-0650
J9 AM FAM PHYSICIAN
JI Am. Fam. Physician
PD MAR 15
PY 2015
VL 91
IS 6
BP 378
EP 386
PG 9
WC Primary Health Care; Medicine, General & Internal
SC General & Internal Medicine
GA CD8GO
UT WOS:000351333400010
PM 25822556
ER
PT J
AU Short, N
Hu, SW
Gurram, P
Gurton, K
Chan, A
AF Short, Nathaniel
Hu, Shuowen
Gurram, Prudhvi
Gurton, Kristan
Chan, Alex
TI Improving cross-modal face recognition using polarimetric imaging
SO OPTICS LETTERS
LA English
DT Article
AB We investigate the performance of polarimetric imaging in the long-wave infrared (LWIR) spectrum for cross-modal face recognition. For this work, polarimetric imagery is generated as stacks of three components: the conventional thermal intensity image (referred to as S-0), and the two Stokes images, S-1 and S-2, which contain combinations of different polarizations. The proposed face recognition algorithm extracts and combines local gradient magnitude and orientation information from S-0, S-1, and S-2 to generate a robust feature set that is well-suited for cross-modal face recognition. Initial results show that polarimetric LWIR-to-visible face recognition achieves an 18% increase in Rank-1 identification rate compared to conventional LWIR-to-visible face recognition. We conclude that a substantial improvement in automatic face recognition performance can be achieved by exploiting the polarization-state of radiance, as compared to using conventional thermal imagery. (C) 2015 Optical Society of America
C1 [Short, Nathaniel; Hu, Shuowen; Gurram, Prudhvi; Gurton, Kristan; Chan, Alex] US Army Res Lab, Adelphi, MD 20783 USA.
[Short, Nathaniel] Booz Allen & Hamilton Inc, Mclean, VA 22102 USA.
[Gurram, Prudhvi] MBO Partners, Herndon, VA 20171 USA.
RP Short, N (reprint author), US Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA.
EM nathaniel.j.short2.ctr@mail.mil
NR 10
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PU OPTICAL SOC AMER
PI WASHINGTON
PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA
SN 0146-9592
EI 1539-4794
J9 OPT LETT
JI Opt. Lett.
PD MAR 15
PY 2015
VL 40
IS 6
BP 882
EP 885
DI 10.1364/OL.40.000882
PG 4
WC Optics
SC Optics
GA CD4MI
UT WOS:000351056500009
PM 25768137
ER
PT J
AU Johnson, JB
Gelvin, AB
Duvoy, P
Schaefer, GL
Poole, G
Horton, GD
AF Johnson, Jerome B.
Gelvin, Arthur B.
Duvoy, Paul
Schaefer, Garry L.
Poole, Garry
Horton, Glenn D.
TI Performance characteristics of a new electronic snow water equivalent
sensor in different climates
SO HYDROLOGICAL PROCESSES
LA English
DT Article
DE snow water equivalent; electronic sensor; hydrology; field measurements;
snow pillow
AB The US Army ERDC CRREL and the US Department of Agriculture Natural Resources Conservation Service developed a square electronic snow water equivalent (e-SWE) sensor as an alternative to using fluid-filled snow pillows to measure SWE. The sensors consist of a centre panel to measure SWE and eight outer panels to buffer edge stress concentrations. Seven 3m square e-SWE sensors were installed in five different climate zones. During the 2011-2012 winter, 1.8 and 1.2m square e-SWE sensors were installed and operated in Oregon. With the exception of New York State and Newfoundland, the e-SWE sensors accurately measured SWE, with R-2 values between the sensor and manual SWE measurements of between 0.86 and 0.98. The e-SWE sensor at Hogg Pass, Oregon, accurately measured SWE during the past 8years of operations. In the thin, icy snow of New York during midwinter 2008-2009, the e-SWE sensors overmeasured SWE because of edge stress concentrations associated with strong icy layers and a shallow snow cover. The New York e-SWE sensors' measurement accuracy improved in spring 2009 and further improved during the 2011-2012 winter with operating experience. At Santiam Junction, measured SWE from the 1.8 and 1.2m square e-SWE sensors agreed well with the snow pillow, 3m square e-SWE sensor, and manual SWE measurements until February 2013, when dust and gravel blew onto the testing area resulting in anomalous measurements. (c) 2014 The Authors. Hydrological Processes published by John Wiley & Sons Ltd.
C1 [Johnson, Jerome B.; Duvoy, Paul] Univ Alaska Fairbanks, Inst Northern Engn, Fairbanks, AK 99775 USA.
[Gelvin, Arthur B.] US Army ERDC Cold Reg Res & Engn Lab, Ft Wainwright, AK 99703 USA.
[Schaefer, Garry L.] Nat Resources Conservat Serv, USDA, Portland, OR 97232 USA.
[Poole, Garry] Newfoundland & Labrador Hydro, St John, NF A1B 4K7, Canada.
[Horton, Glenn D.] New York City Environm Protect, Grahamsville, NY 12740 USA.
RP Johnson, JB (reprint author), Univ Alaska Fairbanks, Inst Northern Engn, POB 755910, Fairbanks, AK 99775 USA.
EM jerome.b.johnson@alaska.edu
FU USDA NRCS; Institute of Northern Engineering, University of Alaska
Fairbanks
FX This work was supported by the USDA NRCS and the Institute of Northern
Engineering, University of Alaska Fairbanks. We gratefully acknowledge
the SnowNet project (http://www.ipysnow.net/) for using their
preliminary SWE data for Barrow and Imnavait.
NR 30
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U1 1
U2 5
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0885-6087
EI 1099-1085
J9 HYDROL PROCESS
JI Hydrol. Process.
PD MAR 15
PY 2015
VL 29
IS 6
BP 1418
EP 1433
DI 10.1002/hyp.10211
PG 16
WC Water Resources
SC Water Resources
GA CC7LD
UT WOS:000350548100047
ER
PT J
AU Tao, L
Cinquanta, E
Chiappe, D
Grazianetti, C
Fanciulli, M
Dubey, M
Molle, A
Akinwande, D
AF Tao, Li
Cinquanta, Eugenio
Chiappe, Daniele
Grazianetti, Carlo
Fanciulli, Marco
Dubey, Madan
Molle, Alessandro
Akinwande, Deji
TI Silicene field-effect transistors operating at room temperature
SO NATURE NANOTECHNOLOGY
LA English
DT Article
ID ELECTRONIC-PROPERTIES; AG(111); NANORIBBONS; GRAPHENE; LAYERS
AB Free-standing silicene, a silicon analogue of graphene, has a buckled honeycomb lattice(1) and, because of its Dirac bandstructure(2,3) combined with its sensitive surface, offers the potential for a widely tunable two-dimensional monolayer, where external fields and interface interactions can be exploited to influence fundamental properties such as bandgap(4) and band character(5) for future nanoelectronic devices(6,7). The quantum spin Hall effect(3), chiral superconductivity(8), giant magnetoresistance(9) and various exotic field-dependent states7 have been predicted in monolayer silicene. Despite recent progress regarding the epitaxial synthesis of silicene(8-10) and investigation of its electronic properties(11,13-15), to date there has been no report of experimental silicene devices because of its air stability issue(16). Here, we report a silicene field-effect transistor, corroborating theoretical expectations regarding its ambipolar Dirac charge transport(17), with a measured roomtemperature mobility of similar to 100 cm(2) V-1 s(-1) attributed to acoustic phonon-limited transport(18) and grain boundary scattering. These results are enabled by a growth-transfer-fabrication process that we have devised-silicene encapsulated delamination with native electrodes. This approach addresses a major challenge for material preservation of silicene during transfer and device fabrication and is applicable to other air-sensitive two-dimensional materials such as germanene(2-4) and phosphorene(19,20). Silicene's allotropic affinity with bulk silicon and its low-temperature synthesis compared with graphene or alternative two-dimensional semiconductors suggest a more direct integration with ubiquitous semiconductor technology.
C1 [Tao, Li; Akinwande, Deji] Univ Texas Austin, Microelect Res Ctr, Austin, TX 78758 USA.
[Cinquanta, Eugenio; Chiappe, Daniele; Grazianetti, Carlo; Fanciulli, Marco; Molle, Alessandro] IMM CNR, Lab MDM, I-20864 Agrate Brianza, Italy.
[Dubey, Madan] US Army Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20723 USA.
RP Molle, A (reprint author), IMM CNR, Lab MDM, Via C Olivetti 2, I-20864 Agrate Brianza, Italy.
EM alessandro.molle@mdm.imm.cnr.it; deji@ece.utexas.edu
RI Tao, Li/D-3622-2012; Fanciulli, Marco/J-9940-2013; Molle,
Alessandro/D-8952-2013; Cinquanta, Eugenio/J-7747-2016
OI Grazianetti, Carlo/0000-0003-0060-9804; Tao, Li/0000-0001-6055-6068;
Fanciulli, Marco/0000-0003-2951-0859; Molle,
Alessandro/0000-0002-3860-4120; Cinquanta, Eugenio/0000-0002-4721-5215
FU Army Research Office [W911NF-13-1-0364]; Southwest Academy of
Nanoelectronics (SWAN) centre - Semiconductor Research Corporation
(SRC); Future and Emerging Technologies (FET) programme within the
Seventh Framework Program for Research of the European Commission (FET)
[270749]; TI/Jack Kilby Faculty Fellowship
FX This work is supported in part by the Army Research Office (contract
W911NF-13-1-0364), the Southwest Academy of Nanoelectronics (SWAN)
centre sponsored by the Semiconductor Research Corporation (SRC) and the
Future and Emerging Technologies (FET) programme within the Seventh
Framework Program for Research of the European Commission (FET-Open
grant number 270749, '2D-Nanolattices' project). D.A. acknowledges the
TI/Jack Kilby Faculty Fellowship. The authors thank A. Nayak and J.
Wozniak of Texas Advanced Computing Centre (TACC) for their help with
the three-dimensional rendering of Figure 1.
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PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1748-3387
EI 1748-3395
J9 NAT NANOTECHNOL
JI Nat. Nanotechnol.
PD MAR 15
PY 2015
VL 10
IS 3
BP 227
EP 231
DI 10.1038/NNANO.2014.325
PG 5
WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary
SC Science & Technology - Other Topics; Materials Science
GA CD0YG
UT WOS:000350799700012
PM 25643256
ER
PT J
AU Hanrahan, B
Misra, S
Waits, CM
Ghodssi, R
AF Hanrahan, Brendan
Misra, Saswat
Waits, C. Mike
Ghodssi, Reza
TI Wear mechanisms in microfabricated ball bearing systems
SO WEAR
LA English
DT Article
DE Rolling friction; Micro-abrasion; Galling; Bearings; Surface analysis
ID MICROBALL BEARINGS; PHASE-TRANSFORMATIONS; SILICON; FRICTION; MEMS;
LUBRICATION; INDENTATION; TEMPERATURE; DESIGN
AB Microfabricated ball bearings have been demonstrated successfully in a number of microsystems, although a complete understanding of their tribological properties remains elusive. This paper investigates the wear mechanisms for a microfabricated ball bearing platform that includes silicon and thin-film coated silicon raceway/steel ball materials systems. Adhesion of ball material, found to be the primary wear mechanism, is universally present in all tested materials systems. Volumetric adhesive wear rates are observed between 4 x 10(-4) and 4 x 10(-5) mu m(3)/mN.rev. Pressured-induced phase changes take place in the contact areas of the bare silicon raceways, observed with Raman spectroscopy. An understanding of the wear mechanisms within microfabricated ball bearings will help optimize operational parameters and materials systems for long-term reliability. (C) 2015 Elsevier B.V. All rights reserved.
C1 [Hanrahan, Brendan] Univ Maryland, Mat Sci & Engn Dept, College Pk, MD 20704 USA.
[Misra, Saswat; Ghodssi, Reza] Univ Maryland, Syst Res Inst, Elect & Comp Engn Dept, College Pk, MD 20704 USA.
[Waits, C. Mike] US Army, Res Lab, Adelphi, MD 20783 USA.
RP Ghodssi, R (reprint author), Univ Maryland, Syst Res Inst, Elect & Comp Engn Dept, 2173 AV Williams Bldg, College Pk, MD 20704 USA.
EM ghodssi@umd.edu
FU U.S. National Science Foundation [0901411]
FX This work was supported by the U.S. National Science Foundation under
award No. 0901411. We would also like to acknowledge the Maryland
Nanocenter and the U.S. Army Research Laboratory Cleanroom Staff.
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PU ELSEVIER SCIENCE SA
PI LAUSANNE
PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND
SN 0043-1648
EI 1873-2577
J9 WEAR
JI Wear
PD MAR 15
PY 2015
VL 326
BP 1
EP 9
DI 10.1016/j.wear.2014.12.032
PG 9
WC Engineering, Mechanical; Materials Science, Multidisciplinary
SC Engineering; Materials Science
GA CD2VP
UT WOS:000350937400001
ER
PT J
AU Palomino, JM
Tran, DT
Kareh, AR
Miller, CA
Gardner, JMV
Dong, H
Oliver, SRJ
AF Palomino, Jessica M.
Tran, Dat T.
Kareh, Ana R.
Miller, Christopher A.
Gardner, Joshua M. V.
Dong, Hong
Oliver, Scott R. J.
TI Zirconia-silica based mesoporous desulfurization adsorbents
SO JOURNAL OF POWER SOURCES
LA English
DT Article
DE Mesoporous silica; Desulfurization; JP-8 jet fuel; Adsorbents
ID DEEP DESULFURIZATION; ADSORPTIVE DESULFURIZATION; SELECTIVE ADSORPTION;
JET FUEL; ROOM-TEMPERATURE; PARTICLE-SIZE; DIESEL FUEL; CATALYSTS;
GASOLINE; SULFUR
AB We report a series of mesoporous silicate sorbent materials templated by long-chain primary alkyl-amines that display record level of desulfurization of the jet fuel JP-8. Pure silica frameworks and those with a Si:Zr synthesis molar ratio ranging from 44:1 to 11:1 were investigated. The optimum sorbent was identified as dodecylamine-templated silica-zirconia synthesized from a gel with Si:Zr molar ratio of 15:1. With an optimized silver loading of 11 wt.%, a saturation adsorption capacity of 39.4 mgS g(-1) and a silver efficiency of 1.21 moIS mol Ag-1 were observed for JP-8. This sorbent displayed exceptional regenerability, maintaining 86% of its initial capacity in model fuel after solvent regeneration with diethyl ether. Low-cost, portable and reusable sorbents for the desulfurization of JP-8 jet fuel are needed to make solid oxide fuel cells (SOFCs) a reality for military power needs. SOFCs require ultra-low sulfur content fuel, which traditional desulfurization methods cannot achieve. (C) 2014 Elsevier B.V. All rights reserved.
C1 [Palomino, Jessica M.; Kareh, Ana R.; Miller, Christopher A.; Gardner, Joshua M. V.; Oliver, Scott R. J.] Univ Calif Santa Cruz, Dept Chem & Biochem, Santa Cruz, CA 95064 USA.
[Tran, Dat T.] US Army, Res Lab, Adelphi, MD 20783 USA.
[Dong, Hong] US Army, Res Lab, Aberdeen Proving Ground, MD 21005 USA.
RP Tran, DT (reprint author), Univ Calif Santa Cruz, Dept Chem & Biochem, Santa Cruz, CA 95064 USA.
EM dat.t.tran4.civ@mail.mil; soliver@ucsc.edu
OI Vecchione Gardner, Joshua/0000-0003-4386-0628
FU DOD ARL [W911NF-12-2-0005]
FX This work was supported by DOD ARL, Contract No. W911NF-12-2-0005. We
acknowledge Dr. Tom Yuzvinsky for image acquisition and the W.M. Keck
Center for Nanoscale Optofluidics at UC Santa Cruz for use of the FEI
Quanta 3D Dualbeam microscope.
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U2 44
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-7753
EI 1873-2755
J9 J POWER SOURCES
JI J. Power Sources
PD MAR 15
PY 2015
VL 278
BP 141
EP 148
DI 10.1016/j.jpowsour.2014.12.043
PG 8
WC Chemistry, Physical; Electrochemistry; Energy & Fuels; Materials
Science, Multidisciplinary
SC Chemistry; Electrochemistry; Energy & Fuels; Materials Science
GA CC2NH
UT WOS:000350181400018
ER
PT J
AU Kalambate, PK
Dar, RA
Karna, SP
Srivastava, AK
AF Kalambate, Pramod K.
Dar, Riyaz A.
Karna, Shashi P.
Srivastava, Ashwini K.
TI High performance supercapacitor based on graphene-silver
nanoparticles-polypyrrole nanocomposite coated on glassy carbon
electrode (vol 276, pg 262, 2014)
SO JOURNAL OF POWER SOURCES
LA English
DT Correction
C1 [Kalambate, Pramod K.; Dar, Riyaz A.; Srivastava, Ashwini K.] Univ Mumbai, Dept Chem, Bombay 400098, Maharashtra, India.
[Karna, Shashi P.] US Army Res Lab, Weap & Mat Res Directorate, ATTN RDRL WM, Aberdeen Proving Ground, MD 21005 USA.
RP Srivastava, AK (reprint author), Univ Mumbai, Dept Chem, Bombay 400098, Maharashtra, India.
EM aksrivastava@chem.mu.ac.in
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U1 10
U2 76
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-7753
EI 1873-2755
J9 J POWER SOURCES
JI J. Power Sources
PD MAR 15
PY 2015
VL 278
BP 828
EP 828
DI 10.1016/j.jpowsour.2014.12.114
PG 1
WC Chemistry, Physical; Electrochemistry; Energy & Fuels; Materials
Science, Multidisciplinary
SC Chemistry; Electrochemistry; Energy & Fuels; Materials Science
GA CC2NH
UT WOS:000350181400099
ER
PT J
AU Whipps, GT
Ertin, E
Moses, RL
AF Whipps, Gene T.
Ertin, Emre
Moses, Randolph L.
TI Distributed Detection of Binary Decisions with Collisions in a Large,
Random Network
SO IEEE TRANSACTIONS ON SIGNAL PROCESSING
LA English
DT Article
DE Binary sensors; distributed detection; local vote; point process; random
access; random sensor network
ID SENSOR NETWORKS
AB We consider the problem of distributed detection in a large network of sensors. A random number of sensor nodes are randomly deployed. Sensor nodes perform local detection tests and communicate detections over a multiple-access channel to a fusion center. The fusion center can recognize both successful communications and communication collisions in the channel. We derive decision rules for both perfect communications and a delay-constrained communications protocol, and show that each are functions of count statistics only. We derive analytical expressions that characterize the performance of the system in terms of detection performance. We analyze performance with respect to sensor density and with respect to communications delay. Simulation examples validate theoretical predictions with numerical results. We show that the detection performance improves with network density despite increasing communication collisions. In addition, we show that detection performance using the protocol model, with imperfect communications, rapidly converges to the perfect communications case as the number of communication slots increase.
C1 [Whipps, Gene T.] US Army Res Lab, Adelphi, MD 20783 USA.
[Whipps, Gene T.; Ertin, Emre; Moses, Randolph L.] Ohio State Univ, Dept Elect & Comp Engn, Columbus, OH 43210 USA.
RP Whipps, GT (reprint author), US Army Res Lab, Adelphi, MD 20783 USA.
EM whipps.8@osu.edu; ertin.1@osu.edu; moses.2@osu.edu
FU U.S. Army Research Laboratory; ARO [W911NF-11-1-0391]
FX Date of publication February 06, 2015; date of current version February
13, 2015. The associate editor coordinating the review of this
manuscript and approving it for publication was. The research reported
here was partially supported by the U.S. Army Research Laboratory and by
a grant from ARO, W911NF-11-1-0391.
NR 13
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U1 0
U2 2
PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
PI PISCATAWAY
PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA
SN 1053-587X
EI 1941-0476
J9 IEEE T SIGNAL PROCES
JI IEEE Trans. Signal Process.
PD MAR 15
PY 2015
VL 63
IS 6
BP 1477
EP 1489
DI 10.1109/TSP.2015.2398843
PG 13
WC Engineering, Electrical & Electronic
SC Engineering
GA CC0SL
UT WOS:000350046600010
ER
PT J
AU Query, PR
AF Query, Patrick R.
TI Never Let Me Go and the Horizons of the Novel
SO CRITIQUE-STUDIES IN CONTEMPORARY FICTION
LA English
DT Article
DE Never Let Me Go; the novel; Kazuo Ishiguro; Jose Ortega y Gasset;
acceptance
AB This essay examines Kazuo Ishiguro's Never Let Me Go as a metaphor for novel reading. It addresses in particular the main characters' abiding and troubling acceptance of their circumstances. It uses the theories of Jose Ortega y Gasset and Walter Benjamin to build the argument that, by thematizing acceptance, Never Let Me Go demonstrates the reader's own nearly automatic practice of assenting to the created world of a novel.
C1 US Mil Acad, West Point, NY 10996 USA.
RP Query, PR (reprint author), US Mil Acad, West Point, NY 10996 USA.
NR 12
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U1 0
U2 11
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND
SN 0011-1619
EI 1939-9138
J9 CRITIQUE-ST CONTEMP
JI Crit.-Stud. Contemp. Fiction
PD MAR 15
PY 2015
VL 56
IS 2
BP 155
EP 172
DI 10.1080/00111619.2013.868339
PG 18
WC Literature
SC Literature
GA CC0PA
UT WOS:000350036800003
ER
PT J
AU Ghoshal, A
Ayers, J
Gurvich, M
Urban, M
Bordick, N
AF Ghoshal, Anindya
Ayers, James
Gurvich, Mark
Urban, Michael
Bordick, Nathaniel
TI Experimental investigations in embedded sensing of composite components
in aerospace vehicles
SO COMPOSITES PART B-ENGINEERING
LA English
DT Article
DE Laminated composites; Polymer matrix composites (PMCs); Non-destructive
testing; Delamination; Optical properties/techniques
ID DELAMINATION DETECTION; FIBEROPTIC SENSORS; GRATING SENSORS; PATCHES;
IMPACT
AB This paper summarizes the experimental investigations for smart embedded sensing in rotorcraft composite components. The overall objective of this effort was to develop smart embedded sensor technologies for condition based maintenance (CBM) for composite components in army rotorcraft. This paper presents the results of experimental investigations related to development and maturation of different types of embedded sensing solutions for structural health monitoring of composite components including Fiber Bragg Grating (FBG) sensors, phased and discrete piezoelectric sensor arrays. A discussion is provided relative to embedment of optical fibers into composites, and the results from embedded FBG sensors in a rotorcraft flexbeam subcomponent test specimen with seeded delamination subjected to dynamic loading. Likewise, results are analyzed of surface mounted phased array and embedded smart piezoelectric sensors in the flexbeam subcomponent test specimen with embedded delamination, subjected to fatigue cyclic loading. The paper also summarizes the lessons learned from efforts to nucleate and propagate delamination within composite components under dynamic cyclic loading. Published by Elsevier Ltd.
C1 [Ghoshal, Anindya] US Army, Res Lab, Vehicle Technol Directorate, Aberdeen Proving Ground, MD 21005 USA.
[Ayers, James] Honeywell Aerosp, Mech Syst Struct & Dynam, Phoenix, AZ 85034 USA.
[Gurvich, Mark] United Technol Res Ctr, E Hartford, CT 06105 USA.
[Urban, Michael] Sikorsky Aircraft Corp, Stratford, CT 06615 USA.
[Bordick, Nathaniel] Army Aviat Appl Technol Directorate, Ft Eustis, VA 23604 USA.
RP Ghoshal, A (reprint author), US Army, Res Lab, Vehicle Technol Directorate, Aberdeen Proving Ground, MD 21005 USA.
EM anindya.ghoshal.civ@mail.mil
FU [W911W6-08-2-0002]
FX This research is partially funded by the Government under Agreement No.
W911W6-08-2-0002. The US Government is authorized to reproduce and
distribute reprints for Government purposes notwithstanding any
copyright notation thereon. The views and conclusions contained in this
document are those of the authors and should not be interpreted as
representing the official policies, either expressed or implied, of the
Aviation Applied Technology Directorate or the US Government.
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PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1359-8368
EI 1879-1069
J9 COMPOS PART B-ENG
JI Compos. Pt. B-Eng.
PD MAR 15
PY 2015
VL 71
BP 52
EP 62
DI 10.1016/j.compositesb.2014.10.050
PG 11
WC Engineering, Multidisciplinary; Materials Science, Composites
SC Engineering; Materials Science
GA CA4QG
UT WOS:000348889100007
ER
PT J
AU Bhoomiboonchoo, P
Nisalak, A
Chansatiporn, N
Yoon, IK
Kalayanarooj, S
Thipayamongkolgul, M
Endy, T
Rothman, AL
Green, S
Srikiatkhachorn, A
Buddhari, D
Mammen, P
Gibbons, RV
AF Bhoomiboonchoo, Piraya
Nisalak, Ananda
Chansatiporn, Natkamol
Yoon, In-Kyu
Kalayanarooj, Siripen
Thipayamongkolgul, Mathuros
Endy, Timothy
Rothman, Alan L.
Green, Sharone
Srikiatkhachorn, Anon
Buddhari, Darunee
Mammen, Mammen P.
Gibbons, Robert V.
TI Sequential dengue virus infections detected in active and passive
surveillance programs in Thailand, 1994-2010
SO BMC PUBLIC HEALTH
LA English
DT Article
ID PRIMARY-SCHOOL CHILDREN; HEMORRHAGIC-FEVER; SHOCK SYNDROME;
TIME-INTERVAL; KAMPHAENG PHET; ETHNIC THAIS; DISEASE; PROTECTION;
MOSQUITOS; RISK
AB Background: The effect of prior dengue virus (DENV) exposure on subsequent heterologous infection can be beneficial or detrimental depending on many factors including timing of infection. We sought to evaluate this effect by examining a large database of DENV infections captured by both active and passive surveillance encompassing a wide clinical spectrum of disease.
Methods: We evaluated datasets from 17 years of hospital-based passive surveillance and nine years of cohort studies, including clinical and subclinical DENV infections, to assess the outcomes of sequential heterologous infections. Chi square or Fisher's exact test was used to compare proportions of infection outcomes such as disease severity; ANOVA was used for continuous variables. Multivariate logistic regression was used to assess risk factors for infection outcomes.
Results: Of 38,740 DENV infections, two or more infections were detected in 502 individuals; 14 had three infections. The mean ages at the time of the first and second detected infections were 7.6 +/- 3.0 and 11.2 +/- 3.0 years. The shortest time between sequential infections was 66 days. A longer time interval between sequential infections was associated with dengue hemorrhagic fever (DHF) in the second detected infection (OR 1.3, 95% CI 1.2-1.4). All possible sequential serotype pairs were observed among 201 subjects with DHF at the second detected infection, except DENV-4 followed by DENV-3. Among DENV infections detected in cohort subjects by active study surveillance and subsequent non-study hospital-based passive surveillance, hospitalization at the first detected infection increased the likelihood of hospitalization at the second detected infection.
Conclusions: Increasing time between sequential DENV infections was associated with greater severity of the second detected infection, supporting the role of heterotypic immunity in both protection and enhancement. Hospitalization was positively associated between the first and second detected infections, suggesting a possible predisposition in some individuals to more severe dengue disease.
C1 [Bhoomiboonchoo, Piraya; Nisalak, Ananda; Yoon, In-Kyu; Buddhari, Darunee] Armed Forces Res Inst Med Sci, Dept Virol, Bangkok 10400, Thailand.
[Bhoomiboonchoo, Piraya; Chansatiporn, Natkamol; Thipayamongkolgul, Mathuros] Mahidol Univ, Fac Publ Hlth, Bangkok 10700, Thailand.
[Kalayanarooj, Siripen] Queen Sirikit Natl Inst Child Hlth, Bangkok, Thailand.
[Endy, Timothy] SUNY Syracuse, Dept Infect Dis, Syracuse, NY USA.
[Rothman, Alan L.] Univ Rhode Isl, Providence, RI 02908 USA.
[Green, Sharone; Srikiatkhachorn, Anon] Univ Massachusetts, Sch Med, Div Infect Dis & Immunol, Worcester, MA USA.
[Mammen, Mammen P.] Vical Inc, San Diego, CA USA.
[Gibbons, Robert V.] US Army, Inst Surg Res, San Antonio, TX USA.
RP Bhoomiboonchoo, P (reprint author), Armed Forces Res Inst Med Sci, Dept Virol, Bangkok 10400, Thailand.
EM augurivicky@gmail.com
FU NIAID NIH HHS [P01 AI034533]
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PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1471-2458
J9 BMC PUBLIC HEALTH
JI BMC Public Health
PD MAR 14
PY 2015
VL 15
AR 250
DI 10.1186/s12889-015-1590-z
PG 10
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA CD8KY
UT WOS:000351345000001
PM 25886528
ER
PT J
AU Xu, BL
Gonella, G
DeLacy, BG
Dai, HL
AF Xu, Bolei
Gonella, Grazia
DeLacy, Brendan G.
Dai, Hai-Lung
TI Adsorption of Anionic Thiols on Silver Nanoparticles
SO JOURNAL OF PHYSICAL CHEMISTRY C
LA English
DT Article
ID SELF-ASSEMBLED MONOLAYERS; OPTICAL 2ND-HARMONIC GENERATION; NONLINEAR
LIGHT-SCATTERING; GOLD NANOPARTICLES; PARTICLE-SIZE; FREE-ENERGY;
SURFACE; AU(111); NANOSTRUCTURES; ALKANETHIOLS
AB The adsorption of negatively charged 3-mercaptopropanesulfonate (MPS) on the surface of citrate stabilized Ag thartopartides in water is investigated using colloidal particle Surface sensitive techniques. The adsorption of this negatively charged thiol appears to be qualitatively different from that of neutral thiols and highlights the importance of repulsive interactions of electrostatic and aerie origins pertaining to charged thicilS. For the charged MPS thiol, the adsorption process occurs in two phases. At low Surface coverage, the intermolecular repialsiolleis negligible and the adsorption is dominated by the formation of the S-Ag bond, MPS molecules need to overcome an activation energy barrier (7.5 +/- 0.9) kcal/mol with an associated free energy change Delta G(ads) = -(14.3 +/- 0.3) kcal/mol and behave similar to neutrkthiols. On the other hand, at high surface coverage Where the repulsive interactions among MPS molecules cannot be neglected, the adsorption is Characterized by a higher E-a = (12.4 0.5) kcal/mol and lower Delta G(ads) = -(7.4 +/- 0.1) kcal/mol.
C1 [Xu, Bolei; Gonella, Grazia; Dai, Hai-Lung] Temple Univ, Dept Chem, Philadelphia, PA 19122 USA.
[DeLacy, Brendan G.] US Army Edgewood Chem Biol Ctr, Res & Technol Directorate, Aberdeen Proving Ground, MD 21010 USA.
RP Gonella, G (reprint author), Max Planck Inst Polymer Res, Ackermannweg 10, D-55128 Mainz, Germany.
EM gonella@mpip-mainz.mpg.de
RI Gonella, Grazia/K-3464-2012; Xu, Bolei/O-8493-2016
OI Xu, Bolei/0000-0001-5352-0139
FU STC through Edgewood Chemical Biological Center Research and Technology
Directorate [13-01-9030-003, W911SR-10-D0010]; AFOSR [FA-9550-08-1-0092]
FX This work was supported by the STC 13-01-9030-003 grant (through the
Edgewood Chemical Biological Center Research and Technology Directorate
Task Order W911SR-10-D0010). We acknowledge AFOSR for providing the
equipment for the nonlinear light scattering experiment through grant
FA-9550-08-1-0092. We thank Ms. Samantha L. Shumlas for assistance with
the TEM, Prof. S. L. Wunder for the use of the DLS instrument, Prof. B.
Wayland for the use of the spectrophotometer, and Prof. E. Borguet for
useful discussions.
NR 50
TC 3
Z9 3
U1 2
U2 25
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 1932-7447
J9 J PHYS CHEM C
JI J. Phys. Chem. C
PD MAR 12
PY 2015
VL 119
IS 10
BP 5454
EP 5461
DI 10.1021/jp511997w
PG 8
WC Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science,
Multidisciplinary
SC Chemistry; Science & Technology - Other Topics; Materials Science
GA CD6HB
UT WOS:000351189100024
ER
PT J
AU Mait, JN
Mahalanobis, A
Neifeld, MA
Athale, RA
AF Mait, Joseph N.
Mahalanobis, Abhijit
Neifeld, Mark A.
Athale, Ravindra A.
TI Compressive Sensing Focus Issue: introduction
SO APPLIED OPTICS
LA English
DT Editorial Material
C1 [Mait, Joseph N.] US Army Res Lab, RDRL D, Adelphi, MD 20783 USA.
[Mahalanobis, Abhijit] Lockheed Martin Corp, Orlando, FL 32819 USA.
[Neifeld, Mark A.] Univ Arizona, Dept Elect & Comp Engn, Tucson, AZ 85721 USA.
[Athale, Ravindra A.] Off Naval Res, Arlington, VA 22203 USA.
RP Mait, JN (reprint author), US Army Res Lab, RDRL D, 2800 Powder Mill Rd, Adelphi, MD 20783 USA.
EM joseph.n.mait2.civ@mail.mil
NR 2
TC 1
Z9 1
U1 2
U2 8
PU OPTICAL SOC AMER
PI WASHINGTON
PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA
SN 1559-128X
EI 2155-3165
J9 APPL OPTICS
JI Appl. Optics
PD MAR 10
PY 2015
VL 54
IS 8
BP CS1
EP CS3
DI 10.1364/AO.54.000CS1
PG 3
WC Optics
SC Optics
GA CC9AE
UT WOS:000350658900004
PM 25968401
ER
PT J
AU Glaros, TG
Blancett, CD
Bell, TM
Natesan, M
Ulrich, RG
AF Glaros, Trevor G.
Blancett, Candace D.
Bell, Todd M.
Natesan, Mohan
Ulrich, Robert G.
TI Serum biomarkers of Burkholderia mallei infection elucidated by
proteomic imaging of skin and lung abscesses
SO CLINICAL PROTEOMICS
LA English
DT Article
DE Imaging mass spectrometry; Biomarker; Burkholderia mallei; Burkholderia
pseudomallei; Laser capture microdissection; LC-MS/MS; Protein
microarray; Glanders; Melioidosis; GroEL; Calprotectin; Formalin-fixed
paraffin embedded tissue; FFPE
ID FORMALDEHYDE-INDUCED MODIFICATIONS; HEAT-SHOCK PROTEINS;
MASS-SPECTROMETRY; GLANDERS; GROEL; IDENTIFICATION; PEPTIDES;
PSEUDOMALLEI; VACCINATION; SAMPLES
AB Background: The bacterium Burkholderia mallei is the etiological agent of glanders, a highly contagious, often fatal zoonotic infectious disease that is also a biodefense concern. Clinical laboratory assays that analyze blood or other biological fluids are the highest priority because these specimens can be collected with minimal risk to the patient. However, progress in developing sensitive assays for monitoring B. mallei infection is hampered by a shortage of useful biomarkers.
Results: Reasoning that there should be a strong correlation between the proteomes of infected tissues and circulating serum, we employed imaging mass spectrometry (IMS) of thin-sectioned tissues from Chlorocebus aethiops (African green) monkeys infected with B. mallei to localize host and pathogen proteins that were associated with abscesses. Using laser-capture microdissection of specific regions identified by IMS and histology within the tissue sections, a more extensive proteomic analysis was performed by a technique that combined the physical separation capabilities of liquid chromatography (LC) with the sensitive mass analysis capabilities of mass spectrometry (LC-MS/MS). By examining standard formalin-fixed, paraffin-embedded tissue sections, this strategy resulted in the identification of several proteins that were associated with lung and skin abscesses, including the host protein calprotectin and the pathogen protein GroEL. Elevated levels of calprotectin detected by ELISA and antibody responses to GroEL, measured by a microarray of the bacterial proteome, were subsequently detected in the sera of C. aethiops, Macaca mulatta, and Macaca fascicularis primates infected with B. mallei.
Conclusions: Our results demonstrate that a combination of multidimensional MS analysis of traditional histology specimens with high-content protein microarrays can be used to discover lead pairs of host-pathogen biomarkers of infection that are identifiable in biological fluids.
C1 [Glaros, Trevor G.; Natesan, Mohan; Ulrich, Robert G.] USAMRIID, Mol & Translat Sci, Frederick, MD 21702 USA.
[Blancett, Candace D.; Bell, Todd M.] US Army, Pathol, Med Res Inst Infect Dis, Frederick, MD 21702 USA.
RP Ulrich, RG (reprint author), USAMRIID, Mol & Translat Sci, Frederick, MD 21702 USA.
EM rulrich@bhsai.org
FU Defense Threat Reduction Agency [CB3498]
FX This project was supported in part by contract CB3498 (RGU) from the
Defense Threat Reduction Agency and by appointment of TGG to the
Research Participation Program for the U.S. Army Medical Research and
Materiel Command, administered through an agreement with the U.S.
Department of Energy.
NR 32
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U1 4
U2 5
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1542-6416
EI 1559-0275
J9 CLIN PROTEOM
JI Clin. Proteom.
PD MAR 10
PY 2015
VL 12
AR 7
DI 10.1186/s12014-015-9079-4
PG 14
WC Biochemical Research Methods
SC Biochemistry & Molecular Biology
GA DF2XB
UT WOS:000371206600001
PM 26034464
ER
PT J
AU Cahill, JP
Okusaga, O
Zhou, WM
Menyuk, CR
Carter, GM
AF Cahill, James P.
Okusaga, Olukayode
Zhou, Weimin
Menyuk, Curtis R.
Carter, Gary M.
TI Superlinear growth of Rayleigh scattering-induced intensity noise in
single-mode fibers
SO OPTICS EXPRESS
LA English
DT Article
ID OPTICAL-FIBERS; BACKSCATTERING; AMPLIFIERS
AB Rayleigh scattering generates intensity noise close to an optical carrier that propagates in a single-mode optical fiber. This noise degrades the performance of optoelectronic oscillators and RF-photonic links. When using a broad linewidth laser, we previously found that the intensity noise power scales linearly with optical power and fiber length, which is consistent with guided entropy mode Rayleigh scattering (GEMRS), a third order nonlinear scattering process, in the spontaneous limit. In this work, we show that this behavior changes significantly with the use of a narrow linewidth laser. Using a narrow linewidth laser, we measured the bandwidth of the intensity noise plateau to be 10 kHz. We found that the scattered noise power scales superlinearly with fiber length up to lengths of 10 km in the frequency range of 500 Hz to 10 kHz, while it scales linearly in the frequency range of 10 Hz to 100 Hz. These results suggest that the Rayleigh-scattering-induced intensity noise cannot be explained by third-order nonlinear scattering in the spontaneous limit, as previously hypothesized. (C) 2015 Optical Society of America
C1 [Cahill, James P.; Okusaga, Olukayode; Zhou, Weimin] US Army, Res Lab, Adelphi, MD 20783 USA.
[Cahill, James P.; Menyuk, Curtis R.; Carter, Gary M.] Univ Maryland, Dept Comp Sci & Elect Engn, Baltimore, MD 21250 USA.
RP Cahill, JP (reprint author), US Army, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA.
EM james.p.cahill.ctr@us.army.mil
NR 18
TC 7
Z9 7
U1 1
U2 7
PU OPTICAL SOC AMER
PI WASHINGTON
PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA
SN 1094-4087
J9 OPT EXPRESS
JI Opt. Express
PD MAR 9
PY 2015
VL 23
IS 5
BP 6400
EP 6407
DI 10.1364/OE.23.006400
PG 8
WC Optics
SC Optics
GA CD2BL
UT WOS:000350878500089
PM 25836860
ER
PT J
AU Stack, DT
Lee, PJ
Quraishi, Q
AF Stack, Daniel T.
Lee, Patricia J.
Quraishi, Qudsia
TI Simple and efficient absorption filter for single photons from a cold
atom quantum memory
SO OPTICS EXPRESS
LA English
DT Article
ID COMMUNICATION; ENSEMBLES; ENTANGLEMENT; VAPOR; LIGHT
AB The ability to filter unwanted light signals is critical to the operation of quantum memories based on neutral atom ensembles. Here we demonstrate an efficient frequency filter which uses a vapor cell filled with Rb-85 and a buffer gas to attenuate both residual laser light and noise photons by nearly two orders of magnitude with little loss to the single photons associated with our cold Rb-87 quantum memory. This simple, passive filter provides an additional 18 dB attenuation of our pump laser and erroneous spontaneous emissions for every 1 dB loss of the single photon signal. We show that the addition of a frequency filter increases the non-classical correlations and the retrieval efficiency of our quantum memory by approximate to 35%. (C) 2015 Optical Society of America
C1 [Stack, Daniel T.; Lee, Patricia J.; Quraishi, Qudsia] US Army, Res Lab, Quantum Sci Grp, Adelphi, MD 20783 USA.
RP Quraishi, Q (reprint author), US Army, Res Lab, Quantum Sci Grp, Adelphi, MD 20783 USA.
EM qudsia.quraishi.civ@mail.mil
FU Army Research Laboratory
FX We would like thank N. Solmeyer, D. Matsukevich, and A. Gorshkov for
discussions on the quantum memory and P. Kunz for discussions on the
vapor cell. DS is an Oak Ridge Associated Universities (ORAU)
postdoctoral fellow. Research was sponsored by the Army Research
Laboratory. The views and conclusions contained in this document are
those of the Authors and should not be interpreted as representing the
official policies, either expressed or implied, of the Army Research
Laboratory or the U.S. Government. The U.S. Government is authorized to
reproduce and distribute reprints for Government purposes
notwithstanding any copyright notation herein.
NR 28
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U1 2
U2 16
PU OPTICAL SOC AMER
PI WASHINGTON
PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA
SN 1094-4087
J9 OPT EXPRESS
JI Opt. Express
PD MAR 9
PY 2015
VL 23
IS 5
BP 6822
EP 6832
DI 10.1364/OE.23.006822
PG 11
WC Optics
SC Optics
GA CD2BL
UT WOS:000350878500130
PM 25836902
ER
PT J
AU Jennings, NA
AF Jennings, Nathan A.
TI Texas Ranger Auxiliaries: Double-Edged Sword of the Campaign for
Northern Mexico, 1846-1848
SO SMALL WARS AND INSURGENCIES
LA English
DT Article
DE counterguerrilla warfare; Mexican War; Texas Rangers; Texas Devils;
Monterrey; Maj. Gen. Zachary Taylor; Federacion Hill
AB This essay explores how federalized Texas Rangers, in the form of scout companies and larger mounted rifle regiments, provided controversial, and ultimately cost-effective, versatility to the US Army during its campaign in Northern Mexico between 1846 and 1848. It argues that their contributions centered on three tactical tasks that enhanced the invading army's maneuvers: reconnaissance, direct assault, and counterguerrilla patrolling. Each of these actions reflected a distinctive skill-set at which the auxiliaries excelled, marking them as exceptionally multifunctional assets. The Texans' augmentation coincided with, and was necessitated by, the evolving stages of the war in Northern Mexico, beginning with the American army's initial invasion, then transitioning to the assault on Monterrey, and finally ending with a troubled occupation where the rangers' brutality both enabled and undermined American pacification efforts.
C1 US Mil Acad, West Point, NY 10996 USA.
RP Jennings, NA (reprint author), US Mil Acad, West Point, NY 10996 USA.
EM nathan.jennings@us.army.mil
NR 49
TC 0
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U1 0
U2 1
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND
SN 0959-2318
EI 1743-9558
J9 SMALL WAR INSUR
JI Small War Insur.
PD MAR 4
PY 2015
VL 26
IS 2
BP 313
EP 334
DI 10.1080/09592318.2015.1007560
PG 22
WC International Relations
SC International Relations
GA CI1CI
UT WOS:000354477900006
ER
PT J
AU Sivasuthan, S
Karthik, VU
Rahunanthan, A
Jayakumar, P
Thyagarajan, RS
Udpa, L
Hoole, SRH
AF Sivasuthan, S.
Karthik, V. U.
Rahunanthan, A.
Jayakumar, P.
Thyagarajan, R. S.
Udpa, Lalita
Hoole, S. R. H.
TI A Script-Based, Parameterized Finite Element Mesh for Design and NDE on
a GPU
SO IETE TECHNICAL REVIEW
LA English
DT Article
DE Optimization; NDE; Finite elements; GPU
ID GRAPHICS PROCESSING UNITS; ELECTROMAGNETIC DEVICES; OPTIMIZATION;
IMPLEMENTATION; COMPUTATION; ALGORITHMS
AB Finite element mesh generators exist in the public domain, a few even based on a parametric device description. The typical mesh generator requires some man-machine interaction to define the points and boundary conditions, and does not work for non-stop optimization iterations for which we need a mesh dynamically evolving through the iterations with optimization variables as changing parameters. Such mesh generators as do exist are rare, commercial, and not easily available to researchers except at great cost and never with the code to modify them to suit individual needs. We take a regular open source mesh generator and write a script-based interface as open source to run non-stop for optimization. We then use it to create a non-destructive evaluation system for army ground vehicles' defect characterization and use it equally for machine design. A simple scheme of averaging neighbour heights gives us a smooth geometry without having to use Bezier curves. The mesh runs on the central processing unit but finite element optimization is on the graphics processing unit for speed and practicable testing times.
C1 [Sivasuthan, S.; Karthik, V. U.; Udpa, Lalita; Hoole, S. R. H.] Michigan State Univ, Dept Elect & Comp Engn, E Lansing, MI 48823 USA.
[Rahunanthan, A.] Edinboro Univ, Dept Math & Comp Sci, Edinboro, PA 16444 USA.
[Jayakumar, P.; Thyagarajan, R. S.] US Army Tank Automot Res Dev & Engn Ctr, Warren, MI 48397 USA.
RP Sivasuthan, S (reprint author), Michigan State Univ, Dept Elect & Comp Engn, E Lansing, MI 48823 USA.
EM sivasuth@msu.edu; uthayaku@msu.edu; rahunanthana@gmail.com;
paramsothy.jayakumar.civ@mail.mil; ravi.s.thyagarajan.civ@mail.mil;
udpal@msu.edu; srhhoole@gmail.com
FU US Army's TARDEC [W911NF-11-D-0001]
FX Funded in part by the US Army's TARDEC [contract number
W911NF-11-D-0001].
NR 41
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U1 1
U2 3
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
SN 0256-4602
EI 0974-5971
J9 IETE TECH REV
JI IETE Tech. Rev.
PD MAR 4
PY 2015
VL 32
IS 2
BP 94
EP 103
DI 10.1080/02564602.2014.983192
PG 10
WC Engineering, Electrical & Electronic; Telecommunications
SC Engineering; Telecommunications
GA CE5AS
UT WOS:000351842700003
ER
PT J
AU Gao, T
Han, FD
Zhu, YJ
Suo, LM
Luo, C
Xu, K
Wang, CS
AF Gao, Tao
Han, Fudong
Zhu, Yujie
Suo, Liumin
Luo, Chao
Xu, Kang
Wang, Chunsheng
TI Hybrid Mg2+/Li+ Battery with Long Cycle Life and High Rate Capability
SO ADVANCED ENERGY MATERIALS
LA English
DT Article
DE daniel cells; dendrite-free magnesium anodes; electrolyte-compatible
cathodes; high reversibility; mixed-ion electrolytes
ID RECHARGEABLE MAGNESIUM BATTERIES; ELECTROLYTE-SOLUTIONS; CURRENT
COLLECTORS; CATHODE MATERIALS; MG BATTERIES; DEPOSITION; CHALLENGE;
STABILITY; CHEMISTRY; PROGRESS
C1 [Gao, Tao; Han, Fudong; Zhu, Yujie; Suo, Liumin; Luo, Chao; Wang, Chunsheng] Univ Maryland, Dept Chem & Biomol Engn, College Pk, MD 20740 USA.
[Xu, Kang] US Army Res Lab, Electrochem Branch, Power & Energy Div, Sensor & Electron Devices Directorate, Adelphi, MD 20783 USA.
RP Wang, CS (reprint author), Univ Maryland, Dept Chem & Biomol Engn, College Pk, MD 20740 USA.
EM cswang@umd.edu
RI Wang, Chunsheng/H-5767-2011
OI Wang, Chunsheng/0000-0002-8626-6381
FU DoE ARPA-E [DEAR0000389]; Maryland NanoCenter, NispLab; NSF as a MRSEC
Shared Experimental Facility
FX This work was supported by DoE ARPA-E (DEAR0000389). The authors
acknowledge the support of the Maryland NanoCenter and its NispLab. The
NispLab is supported in part by the NSF as a MRSEC Shared Experimental
Facility.
NR 34
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Z9 17
U1 19
U2 161
PU WILEY-V C H VERLAG GMBH
PI WEINHEIM
PA BOSCHSTRASSE 12, D-69469 WEINHEIM, GERMANY
SN 1614-6832
EI 1614-6840
J9 ADV ENERGY MATER
JI Adv. Energy Mater.
PD MAR 4
PY 2015
VL 5
IS 5
AR 1401507
DI 10.1002/aenm.201401507
PG 5
WC Chemistry, Physical; Energy & Fuels; Materials Science,
Multidisciplinary; Physics, Applied; Physics, Condensed Matter
SC Chemistry; Energy & Fuels; Materials Science; Physics
GA CD0IP
UT WOS:000350754800011
ER
PT J
AU Hawkins, AD
Thornton, C
Kennedy, AJ
Bu, KX
Cizdziel, J
Jones, BW
Steevens, JA
Willett, KL
AF Hawkins, Adam D.
Thornton, Cammi
Kennedy, Alan J.
Bu, Kaixuan
Cizdziel, James
Jones, Bradley W.
Steevens, Jeffery A.
Willett, Kristine L.
TI Gill Histopathologies Following Exposure to Nanosilver or Silver Nitrate
SO JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES
LA English
DT Article
ID TROUT ONCORHYNCHUS-MYKISS; RAINBOW-TROUT; DISSOLVED SILVER;
DAPHNIA-MAGNA; FISH GILL; TOXICITY; NANOPARTICLES; WATER; FRESH;
ZEBRAFISH
AB Fish gill is the site for many crucial physiological functions. It is among the first sites of xenobiotic exposure, and gill histopathological alterations may be detected soon after toxicant exposure. Silver (Ag) is one of the most toxic metals to aquatic organisms mainly due to its ability to disrupt ionic regulation. The goal of this study was to determine the effect of ionic and nanoscale Ag on fathead minnow gills by examining gill histology and Na+/K+-ATPase immunoreactivity. Fathead minnows were exposed to two measured concentrations of silver nitrate (AgNO3: 1.3 or 3.7 mu g/L as Ag+), citrate silver nanoparticles (citrate-AgNP: 15 or 39 mu g/L), and polyvinylpyrrolidone-AgNP (PVP-AgNP) (AgNP: 11 or 50 mu g/L). Circulatory disturbances were the most prevalent gill alterations detected and were significantly increased in all Ag treatment groups compared to control. AgNO3 (1.3 mu g/L) was the only treatment that significantly elevated the number of total mucous goblet cells present. In all other Ag treatments, the percent of degenerated goblet cells was significantly increased compared to control. When the sum of all histopathological abnormalities (weighted index) was calculated, all Ag groups displayed a significantly higher index, with citrate-AgNP having the highest toxicity (index of 10 +/- 0.32 versus 2.4 +/- 0.6 in controls). Gill Na+/K+-ATPase immunoreactivity was decreased by Ag. These results indicated that both AgNO3 and AgNP created similar disruptions in gill structure and ionic regulation, possibly due to the ionic Ag portion of each treatment.
C1 [Hawkins, Adam D.; Thornton, Cammi; Willett, Kristine L.] Univ Mississippi, Sch Pharm, Dept BioMol Sci, University, MS 38677 USA.
[Hawkins, Adam D.; Thornton, Cammi; Willett, Kristine L.] Univ Mississippi, Sch Pharm, Environm Toxicol Res Program, University, MS 38677 USA.
[Kennedy, Alan J.; Steevens, Jeffery A.] US Army Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS USA.
[Bu, Kaixuan; Cizdziel, James] Univ Mississippi, Dept Chem, University, MS 38677 USA.
[Jones, Bradley W.] Univ Mississippi, Dept Biol, University, MS 38677 USA.
RP Willett, KL (reprint author), Univ Mississippi, Sch Pharm, Dept BioMol Sci, 305 Faser Hall,Box 1848, University, MS 38677 USA.
EM kwillett@olemiss.edu
FU U.S. Army Environmental Quality and Technology Program
FX We thank Catherine Freeland, Frank Booc, and Khalid Alharthy for
assistance with water changes, feedings, and dissections. Dr. Alvin C.
Camus (University of Georgia) provided suggestions related to gill
histopathology. Ashley Harmon (U.S. Army ERDC) performed measurements of
particles in TEM images. This research was supported by the U.S. Army
Environmental Quality and Technology Program (Dr. Elizabeth Ferguson,
Technical Director). Permission was granted by the Chief of Engineers to
publish this information.
NR 55
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U1 0
U2 22
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1528-7394
EI 1087-2620
J9 J TOXICOL ENV HEAL A
JI J. Toxicol. Env. Health Part A
PD MAR 4
PY 2015
VL 78
IS 5
BP 301
EP 315
DI 10.1080/15287394.2014.971386
PG 15
WC Environmental Sciences; Public, Environmental & Occupational Health;
Toxicology
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
Health; Toxicology
GA CC4CN
UT WOS:000350298500002
PM 25734626
ER
PT J
AU Patil, RR
Turgman-Cohen, S
Srogl, J
Kiserow, D
Genzer, J
AF Patil, Rohan R.
Turgman-Cohen, Salomon
Srogl, Jiri
Kiserow, Douglas
Genzer, Jan
TI On-Demand Degrafting and the Study of Molecular Weight and Grafting
Density of Poly(methyl methacrylate) Brushes on Flat Silica Substrates
SO LANGMUIR
LA English
DT Article
ID TRANSFER RADICAL POLYMERIZATION; WELL-DEFINED POLYMER;
COMPUTER-SIMULATION; SURFACE; ATRP; INITIATOR; FRICTION; ADSORPTION;
MONOLAYERS; THICKNESS
AB We report on degrafting of surface-anchored poly(methyl methacrylate) (PMMA) brushes from flat silica-based substrates using tetrabutylammonium fluoride (TBAF) and determining their molecular weight distribution (MWD) using size exclusion chromatography (SEC). The grafted PMMA layer was synthesized using surface-initiated atom transfer radical polymerization (SI-ATRP) of MMA for polymerization times ranging from 6 to 24 h. X-ray photoelectron spectroscopy, ellipsometry, and time-of-flight secondary ion mass spectrometry were employed in tandem to characterize the degrafting process. The SEC eluograms were fit to various polymer distributions, namely Zimm-Schulz, ATRP in continuous stirred tank reactor, Wesslau, Schulz-Flory, and Smith et al. The ATRP model gives the best fit to the experimental data. The dry PMMA brush thickness and the number-average molecular weight (obtained from the MWD) suggest that the grafting density of the PMMA grafts is independent of polymerization time, indicating well-controlled/living growth of MMA. The observed polydispersity index (PDI) was higher than that generally observed in bulk grown polymers under similar conditions, indicating an effect due to chain confinement and crowding. We detect small but noticeable dependence of the polymer brush grafting density on the inhibitor/catalyst ratio. Higher inhibitor/catalyst ratio offers better control with lower early terminations, which results in a small increase in the apparent grafting density of the chains.
C1 [Patil, Rohan R.; Srogl, Jiri; Kiserow, Douglas; Genzer, Jan] N Carolina State Univ, Dept Chem & Biomol Engn, Raleigh, NC 27695 USA.
[Turgman-Cohen, Salomon] Kettering Univ, Dept Chem Engn, Flint, MI 48504 USA.
[Kiserow, Douglas] US Army, Res Off, Res Triangle Pk, NC 27709 USA.
RP Genzer, J (reprint author), N Carolina State Univ, Dept Chem & Biomol Engn, Raleigh, NC 27695 USA.
EM jan_genzer@ncsu.edu
FU National Science Foundation [DMR-0906572]; Army Research Office under
their Staff Research Program [W911NF-04-D-0003-0016]
FX The work was supported by the National Science Foundation (Grant
DMR-0906572) and the Army Research Office under their Staff Research
Program (Grant no. W911NF-04-D-0003-0016).
NR 53
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U1 11
U2 83
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0743-7463
J9 LANGMUIR
JI Langmuir
PD MAR 3
PY 2015
VL 31
IS 8
BP 2372
EP 2381
DI 10.1021/la5044766
PG 10
WC Chemistry, Multidisciplinary; Chemistry, Physical; Materials Science,
Multidisciplinary
SC Chemistry; Materials Science
GA CC8II
UT WOS:000350611300016
PM 25654273
ER
PT J
AU Flinker, A
Korzeniewska, A
Shestyuk, AY
Franaszczuk, PJ
Dronkers, NF
Knight, RT
Crone, NE
AF Flinker, Adeen
Korzeniewska, Anna
Shestyuk, Avgusta Y.
Franaszczuk, Piotr J.
Dronkers, Nina F.
Knight, Robert T.
Crone, Nathan E.
TI Redefining the role of Broca's area in speech
SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF
AMERICA
LA English
DT Article
DE Broca; speech; ECoG
ID WORD PRODUCTION COMPONENTS; EVENT-RELATED CAUSALITY; TEMPORAL
SIGNATURES; AUDITORY-CORTEX; GAMMA ACTIVITY; LANGUAGE; BRAIN;
INFORMATION; DYNAMICS; APHASIA
AB For over a century neuroscientists have debated the dynamics by which human cortical language networks allow words to be spoken. Although it is widely accepted that Broca's area in the left inferior frontal gyrus plays an important role in this process, it was not possible, until recently, to detail the timing of its recruitment relative to other language areas, nor how it interacts with these areas during word production. Using direct cortical surface recordings in neurosurgical patients, we studied the evolution of activity in cortical neuronal populations, as well as the Granger causal interactions between them. We found that, during the cued production of words, a temporal cascade of neural activity proceeds from sensory representations of words in temporal cortex to their corresponding articulatory gestures in motor cortex. Broca's area mediates this cascade through reciprocal interactions with temporal and frontal motor regions. Contrary to classic notions of the role of Broca's area in speech, while motor cortex is activated during spoken responses, Broca's area is surprisingly silent. Moreover, when novel strings of articulatory gestures must be produced in response to non-word stimuli, neural activity is enhanced in Broca's area, but not in motor cortex. These unique data provide evidence that Broca's area coordinates the transformation of information across large-scale cortical networks involved in spoken word production. In this role, Broca's area formulates an appropriate articulatory code to be implemented by motor cortex.
C1 [Flinker, Adeen; Shestyuk, Avgusta Y.; Knight, Robert T.] Univ Calif Berkeley, Helen Wills Neurosci Inst, Berkeley, CA 94720 USA.
[Korzeniewska, Anna; Franaszczuk, Piotr J.; Crone, Nathan E.] Johns Hopkins Univ, Sch Med, Dept Neurol Cognit Neurophysiol, Baltimore, MD 21287 USA.
[Korzeniewska, Anna; Franaszczuk, Piotr J.; Crone, Nathan E.] Johns Hopkins Univ, Sch Med, Brain Machine Interface Lab, Baltimore, MD 21287 USA.
[Franaszczuk, Piotr J.] US Army, Res Lab, Human Res & Engn Directorate, Aberdeen Proving Ground, MD 21005 USA.
[Dronkers, Nina F.] VA Northern Calif Hlth Care Syst, Ctr Aphasia & Related Disorders, Martinez, CA 94553 USA.
[Dronkers, Nina F.] Univ Calif Davis, Dept Neurol, Davis, CA 95817 USA.
[Knight, Robert T.] Univ Calif Berkeley, Dept Psychol, Berkeley, CA 94720 USA.
RP Flinker, A (reprint author), Univ Calif Berkeley, Helen Wills Neurosci Inst, Berkeley, CA 94720 USA.
EM adeen.f@gmail.com
RI Franaszczuk, Piotr/B-6532-2008
OI Franaszczuk, Piotr/0000-0002-5166-4224
FU National Institute of Neurological Disorders and Stroke (NINDS)
[NS40596]; Nielsen Corporation; NIH [2R37NS21135]; NINDS [F31NS065656];
National Institute of Mental Health [F32MH075317]; VA CSR&D Research
Career Scientist Award
FX This work was supported by the National Institute of Neurological
Disorders and Stroke (NINDS) Grant NS40596 (to N.E.C.), the Nielsen
Corporation and the NIH Grant 2R37NS21135 (to R.T.K.), NINDS Grant
F31NS065656 (to A. F.), a VA CSR&D Research Career Scientist Award (to
N.F.D), and the National Institute of Mental Health Grant F32MH075317
(to A.Y.S).
NR 37
TC 20
Z9 20
U1 5
U2 41
PU NATL ACAD SCIENCES
PI WASHINGTON
PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA
SN 0027-8424
J9 P NATL ACAD SCI USA
JI Proc. Natl. Acad. Sci. U. S. A.
PD MAR 3
PY 2015
VL 112
IS 9
BP 2871
EP 2875
DI 10.1073/pnas.1414491112
PG 5
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA CC3DK
UT WOS:000350224900068
PM 25730850
ER
PT J
AU Voronin, Y
Zinszner, H
Karg, C
Brooks, K
Coombs, R
Hural, J
Holt, R
Fast, P
Allen, M
Busch, M
Fruth, U
Golding, H
Khurana, S
Mulenga, J
Peel, S
Schito, M
Voronin, Y
Barnabas, N
Bentsen, C
Graham, B
Gray, G
Levin, A
McCluskey, M
O'Connell, R
Snow, B
Ware, M
AF Voronin, Yegor
Zinszner, Helene
Karg, Carissa
Brooks, Katie
Coombs, Robert
Hural, John
Holt, Renee
Fast, Pat
Allen, Mary
Busch, Michael
Fruth, Ulrich
Golding, Hana
Khurana, Surender
Mulenga, Joseph
Peel, Sheila
Schito, Marco
Voronin, Yegor
Barnabas, Nomampondo
Bentsen, Christopher
Graham, Barney
Gray, Glenda
Levin, Andrew
McCluskey, Margaret
O'Connell, Robert
Snow, Bill
Ware, Mark
CA VISR Working Grp Global HIV Vaccin
TI HIV vaccine-induced sero-reactivity: A challenge for trial participants,
researchers, and physicians
SO VACCINE
LA English
DT Review
DE HIV; Vaccine; Vaccine-induced sero-positivity; Vaccine-induced
sero-reactivity; VISR; VISP
ID DIFFERENTIAL-DIAGNOSIS; GENERATED ANTIBODIES; SEROPOSITIVITY;
INFECTIONS; RECIPIENTS; ASSAY; FACE
AB Antibody-inducing vaccines are a major focus in the preventive HIV vaccine field. Because the most common tests for HIV infection rely on detecting antibodies to HIV, they may also detect antibodies induced by a candidate HIV vaccine. The detection of vaccine-induced antibodies to HIV by serological tests is most commonly referred to as vaccine-induced sero-reactivity (VISR). VISR can be misinterpreted as a sign of HIV infection in a healthy study participant. In a participant who has developed vaccine-induced antibodies, accurate diagnosis of HIV infection (or lack thereof) may require specialized tests and algorithms (differential testing) that are usually not available in community settings. Organizations sponsoring clinical testing of preventive HIV vaccine candidates have an ethical obligation not only to inform healthy volunteers about the potential problems associated with participating in a clinical trial but also to help manage any resulting issues. This article explores the scope of VISR-related issues that become increasingly prevalent as the search for an effective HIV vaccine continues and will be paramount once a preventive vaccine is deployed. We also describe ways in which organizations conducting HIV vaccine trials have addressed these issues and outline areas where more work is needed. (C) 2014 The Authors. Published by Elsevier Ltd.
C1 [Voronin, Yegor; Zinszner, Helene; Voronin, Yegor; Snow, Bill] Global HIV Vaccine Enterprise, New York, NY 10003 USA.
[Karg, Carissa; Brooks, Katie; Hural, John; Holt, Renee] HIV Vaccine Trials Network, Seattle, WA USA.
[Coombs, Robert] Univ Washington, Seattle, WA 98195 USA.
[Fast, Pat] Int AIDS Vaccine Initiat, New York, NY USA.
[Allen, Mary] NIAID, NIH, Bethesda, MD 20892 USA.
[Busch, Michael] Blood Syst Res Inst, San Francisco, CA USA.
[Fruth, Ulrich] WHO, CH-1211 Geneva, Switzerland.
[Golding, Hana] Food & Drug Adm, Bethesda, MD USA.
[Mulenga, Joseph] Zambia Natl Blood Transfus Serv, Lusaka, Zambia.
[Peel, Sheila; O'Connell, Robert] Mil HIV Res Program, Silver Spring, MD USA.
[Schito, Marco] Mil Med Inc, Div Henry M Jackson Fdn Adv, HJF DAIDS, Bethesda, MD USA.
[Barnabas, Nomampondo; Gray, Glenda] Perinatal HIV Res Unit, Johannesburg, South Africa.
[Bentsen, Christopher] Biorad Labs, Redmond, WA USA.
[Graham, Barney] NIAID, Vaccine Res Ctr, NIH, Bethesda, MD 20892 USA.
[Levin, Andrew] Immunetics Inc, Boston, MA USA.
[McCluskey, Margaret] US Agcy Int Dev, Washington, DC 20523 USA.
[O'Connell, Robert] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand.
[Ware, Mark] Clinton Hlth Access Initiat, Edinburgh, Midlothian, Scotland.
RP Voronin, Y (reprint author), Global HIV Vaccine Enterprise, New York, NY 10003 USA.
FU Federal funds from the National Institute of Allergy and Infectious
Diseases, National Institutes of Health, Department of Health and Human
Services [HHSN272200800014C]; United States Agency for International
Development (USAID)
FX We would like to thank all participants of the March 2013 meeting
"Vaccine-Induced Sero-Reactivity/Sero-Positivity", whose opinions
greatly influenced the content of this article. For a complete list of
participants and the meeting report, visit
http://www.vaccineenterprise.org/content/timely-topic-VISP. This project
has been funded in part with Federal funds from the National Institute
of Allergy and Infectious Diseases, National Institutes of Health,
Department of Health and Human Services, under Contract No.
HHSN272200800014C. IAVI's work is made possible by generous support from
many donors, including the United States Agency for International
Development (USAID). A full list of IAVI donors is available at
www.iavi.org.
NR 30
TC 2
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U1 0
U2 6
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0264-410X
EI 1873-2518
J9 VACCINE
JI Vaccine
PD MAR 3
PY 2015
VL 33
IS 10
BP 1243
EP 1249
DI 10.1016/j.vaccine.2014.10.040
PG 7
WC Immunology; Medicine, Research & Experimental
SC Immunology; Research & Experimental Medicine
GA CC1EI
UT WOS:000350083600005
ER
PT J
AU Jasuja, H
Peterson, GW
Decoste, JB
Browe, MA
Walton, KS
AF Jasuja, Himanshu
Peterson, Gregory W.
Decoste, Jared B.
Browe, Matthew A.
Walton, Krista S.
TI Evaluation of MOFs for air purification and air quality control
applications: Ammonia removal from air
SO CHEMICAL ENGINEERING SCIENCE
LA English
DT Article
DE Ammonia; Adsorption; Metal-organic frameworks; Stability; Air
purification; UiO-66
ID METAL-ORGANIC FRAMEWORKS; LIGAND FUNCTIONALIZATION; ADSORPTION;
STABILITY
AB UiO-66 is a Zr-based MOF that is being highly investigated for a wide variety of small molecule gas separations since it possess unprecedented thermal, chemical, and mechanical stability. In this work, we have investigated the performance of various functionalized variations of UiO-66 (UiO-66-OH, UiO-66-(OH)(2), UiO-66-NO2, UiO-66-NH2, UiO-66-SO3H, and UiO-66-(COOH)(2)) towards ammonia removal from air. Functionalized UiO-66 analogs have been synthesized solvothermally and characterized using ammonia breakthrough measurements under dry and humid (80% RH) air conditions along with powder X-ray diffraction (PXRD) patterns and results from BET modeling of N-2 adsorption isotherms. Counter to chemical intuition, our study demonstrates that the ammonia capacities of UiO-66-SO3H and UiO-66-(COOH)(2) are lower than UiO-66-OH and UiO-66-NH2. This is due to significant reduction in the framework porosity (surface area and pore volume) upon functionalization with bulky functional groups such as -COOH and -SO3H. The -OH group is the least bulky functional group considered in the work and interacts favorably with ammonia. UiO-66-OH has a capacity of similar to 5.7 mmol/g for ammonia under dry conditions which is very close to the ammonia removal goal of 0.1 g/g MOF (or similar to 6 mmol/g). However, we observed a decrease in the ammonia capacities of functionalized UiO-66 variations under humid conditions due to competition between water and ammonia molecules for adsorption on the active sites. Overall, balancing the water adsorption behavior and high selectivity and high capacity for ammonia is crucial to developing new adsorbents for ammonia removal from air. (C) 2014 Elsevier Ltd. All rights reserved.
C1 [Jasuja, Himanshu; Walton, Krista S.] Georgia Inst Technol, Sch Chem & Biomol Engn, Atlanta, GA 30332 USA.
[Peterson, Gregory W.; Browe, Matthew A.] US Army, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA.
[Decoste, Jared B.] Leidos Inc, Gunpowder, MD 21010 USA.
RP Walton, KS (reprint author), Georgia Inst Technol, Sch Chem & Biomol Engn, 311 Ferst Dr NW, Atlanta, GA 30332 USA.
EM krista.walton@chbe.gatech.edu
FU Army Research Office PECASE Award [W911NF-10-1-0079, W911NF-10-1-0076]
FX This material is based upon work supported by Army Research Office
PECASE Award W911NF-10-1-0079 and Contract W911NF-10-1-0076.
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U1 21
U2 172
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0009-2509
EI 1873-4405
J9 CHEM ENG SCI
JI Chem. Eng. Sci.
PD MAR 3
PY 2015
VL 124
BP 118
EP 124
DI 10.1016/j.ces.2014.08.050
PG 7
WC Engineering, Chemical
SC Engineering
GA CB2HF
UT WOS:000349447000013
ER
PT J
AU Ivashchenko, VI
Veprek, S
Argon, AS
Turchi, PEA
Gorb, L
Hill, F
Leszczynski, J
AF Ivashchenko, V. I.
Veprek, S.
Argon, A. S.
Turchi, P. E. A.
Gorb, L.
Hill, F.
Leszczynski, J.
TI First-principles quantum molecular calculations of structural and
mechanical properties of TiN/SiNx heterostructures, and the achievable
hardness of the nc-TiN/SiNx nanocomposites
SO THIN SOLID FILMS
LA English
DT Article
DE Superhard nanocomposites; TiN/SiNx heterostructures; First-principles
molecular dynamics; Thermal stability; Stress-strain relations; Ideal
strength; Achievable hardness
ID STRONGEST SIZE; COATINGS; ORIGIN; NC-TIN/A-SI3N4; MICROSTRUCTURE;
NANOSTRUCTURE; DEFORMATION; ENHANCEMENT; IMPURITIES; NITRIDE
AB TiN/SiNx heterostructures with one monolayer of the interfacial SiNx have been investigated in the framework of first-principles molecular dynamics calculations in the temperature range of 0 to 1400 K with subsequent static relaxation. The atomic configurations, thermal stability and stress-strain relations have been calculated. Among the heterostructures studied, only the TiN(111)/SiN/TiN(111) and TiN(111)/Si2N3/TiN(111) ones are thermally stable. Upon tensile load, decohesion occurs between the Ti-N bonds adjacent to the SiNx interfacial layer for TiN(001)/SiN/TiN(001) and TiN(111)/Si2N3/TiN(111) heterostructures, and inside the TiN slab for TiN(001)/Si3N4/TiN(001) and TiN(110)/SiN/TiN(110) ones. Upon shear, failure occurs in TiN near the interfaces in all the heterostructures, except for the TiN(001)/Si3N4/TiN(001) one, for which the plastic flow occurs inside the TiN slab. Based on these results we estimate the maximum achievable hardness of nc-TiN/Si3N4 nanocomposites free of impurities to be about 170 GPa. (C) 2015 Elsevier B.V. All rights reserved.
C1 [Ivashchenko, V. I.] Natl Acad Sci Ukraine, Inst Problems Mat Sci, UA-03142 Kiev, Ukraine.
[Veprek, S.] Tech Univ Munich, Dept Chem, D-85747 Garching, Germany.
[Argon, A. S.] MIT, Dept Mech Engn, Cambridge, MA 02139 USA.
[Turchi, P. E. A.] Lawrence Livermore Natl Lab, L 352, Livermore, CA 94551 USA.
[Gorb, L.] Badger Tech Serv LLC, Vicksburg, MS 39180 USA.
[Gorb, L.; Hill, F.] US Army, Erdc, Vicksburg, MS 39180 USA.
[Leszczynski, J.] Jackson State Univ, Interdisciplinary Ctr Nanotox, Dept Chem & Biochem, Jackson, MS 39217 USA.
RP Veprek, S (reprint author), Tech Univ Munich, Dept Chem, Lichtenbergstr 4, D-85747 Garching, Germany.
EM ivash@ipms.kiev.ua; stan.veprek@lrz.tum.de
RI Veprek, Stan/C-1248-2008
OI Veprek, Stan/0000-0002-6016-3093
FU STCU [5964]; U.S. Department of Energy by the Lawrence Livermore
National Laboratory, Office of Science [DE-AC52-07NA27344]; Summer
Institute at Jackson State University; company SHM; Mechanical
Engineering Department at MIT
FX This work was supported by the STCU contract, No. 5964. The work of P.T.
was performed under the auspices of the U.S. Department of Energy by the
Lawrence Livermore National Laboratory, Office of Science under contract
No. DE-AC52-07NA27344. The authors are grateful to the directorate of
the Summer Institute at Jackson State University for financial support
and the opportunity to perform large-scale calculations. S.V. thanks the
company SHM for financial support. A. S. A. acknowledges support from
the Mechanical Engineering Department at MIT. Our thanks are due to Dr.
Maritza Veprek-Heijman for valuable comments to the manuscript.
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U1 2
U2 30
PU ELSEVIER SCIENCE SA
PI LAUSANNE
PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND
SN 0040-6090
J9 THIN SOLID FILMS
JI Thin Solid Films
PD MAR 2
PY 2015
VL 578
BP 83
EP 92
DI 10.1016/j.tsf.2015.02.013
PG 10
WC Materials Science, Multidisciplinary; Materials Science, Coatings &
Films; Physics, Applied; Physics, Condensed Matter
SC Materials Science; Physics
GA CE2XX
UT WOS:000351686500013
ER
PT J
AU Aurell, J
Gullett, BK
Tabor, D
Williams, RK
Mitchell, W
Kemme, MR
AF Aurell, Johanna
Gullett, Brian K.
Tabor, Dennis
Williams, Ryan K.
Mitchell, William
Kemme, Michael R.
TI Aerostat-based sampling of emissions from open burning and open
detonation of military ordnance
SO JOURNAL OF HAZARDOUS MATERIALS
LA English
DT Article
DE Munitions; Emission factors; Open burning; Open detonation; Static
firing
ID PCDD/PCDF
AB Emissions from open detonation (OD), open burning (OB), and static firing (SF) of obsolete military munitions were collected using an aerostat-lofted sampling instrument maneuvered into the plumes with remotely controlled tether winches. PM2.5, PM10, metals, volatile organic compounds (VOCs), energetics, and polyaromatic hydrocarbons (PAHs) were characterized from 121 trials of three different munitions (Composition B (hereafter, "Comp B"), V453, V548), 152 trials of five different propellants (M31A1E1, M26, SPCF, Arc 451, 452A), and 12 trials with static firing of ammonium perchlorate-containing Sparrow rocket motors. Sampling was conducted with operational charge sizes and under open area conditions to determine emission levels representative of actual disposal practices. The successful application of the tethered aerostat and sampling instruments demonstrated the ability to sample for and determine the first ever emission factors for static firing of rocket motors and buried and metal-cased OD, as well as the first measurements of PM2.5 for OB and for surface OD. Published by Elsevier B.V.
C1 [Aurell, Johanna; Gullett, Brian K.; Tabor, Dennis] US EPA, Off Res & Dev, Natl Risk Management Res Lab, Res Triangle Pk, NC 27711 USA.
[Williams, Ryan K.] US Dept Def, Joint Munit Command, Logist Integrat Directorate, Engn & Demil Technol Off,AMSJM LIB T, Tulsa, OK 74501 USA.
[Mitchell, William] William Mitchell Bill Mitchell & Associates LLC, Durham, NC 27713 USA.
[Kemme, Michael R.] US Army Engn Res & Dev Ctr, Construct Engn Res Lab, Attn CEERD CN E, Champaign, IL 61826 USA.
RP Gullett, BK (reprint author), US EPA, Off Res & Dev, Natl Risk Management Res Lab, Res Triangle Pk, NC 27711 USA.
EM aurell.johanna@epa.gov; gullett.brian@epa.gov; tabor.dennis@epa.gov;
ryan.k.williams.civ@mail.mil; mitcbill@gmail.com;
michael.r.kemme@usace.army.mil
FU Strategic Environmental Research and Development Program; U.S. EPA; U.S.
EPA/NRMRL
FX This work was funded by the Strategic Environmental Research and
Development Program and U.S. EPA. Technical advisors included Keith
Clift, U.S. Army; Randy Cramer, Naval Ordnance Safety and Security
Activity; Eric Erickson, Naval Air Warfare Center-Weapons Division,
China Lake; Tony Livingston, Joint Munitions Command; GeorgeThompson,
Chemical Compliance System, Inc. This research was performed while
Johanna Aurell held a National Research Council Research Associateship
Award at the U.S. EPA/NRMRL. The views expressed in this article are
those of the authors and do not necessarily represent the views or
policies of the U.S. EPA.
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U1 4
U2 22
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0304-3894
EI 1873-3336
J9 J HAZARD MATER
JI J. Hazard. Mater.
PD MAR 2
PY 2015
VL 284
BP 108
EP 120
DI 10.1016/j.jhazmat.2014.10.029
PG 13
WC Engineering, Environmental; Engineering, Civil; Environmental Sciences
SC Engineering; Environmental Sciences & Ecology
GA AY4YX
UT WOS:000347581900014
PM 25463224
ER
PT J
AU Crum-Cianflone, NF
Wang, X
Weintrob, A
Lalani, T
Bavaro, M
Okulicz, JF
Mende, K
Ellis, M
Agan, BK
AF Crum-Cianflone, Nancy F.
Wang, Xun
Weintrob, Amy
Lalani, Tahaniyat
Bavaro, Mary
Okulicz, Jason F.
Mende, Katrin
Ellis, Michael
Agan, Brian K.
TI Specific Behaviors Predict Staphylococcus aureus Colonization and Skin
and Soft Tissue Infections Among Human Immunodeficiency Virus-Infected
Persons
SO OPEN FORUM INFECTIOUS DISEASES
LA English
DT Article
DE behaviors; colonization; HIV; human immunodeficiency virus; MRSA; risk
factors; skin and soft tissue infections; Staphylococcus aureus
ID METHICILLIN-RESISTANT; RISK-FACTORS; NASAL CARRIAGE; HIV-INFECTION; MRSA
INFECTIONS; HEALTHY-ADULTS; DRUG-USERS; PREVALENCE; ASSOCIATION;
OUTPATIENTS
AB Background. Few data exist on the incidence and risk factors of Staphylococcus aureus colonization and skin and soft tissue infections (SSTIs) among patients infected with human immunodeficiency virus (HIV).
Methods. Over a 2-year period, we prospectively evaluated adults infected with HIV for incident S aureus colonization at 5 body sites and SSTIs. Cox proportional hazard models using time-updated covariates were performed.
Results. Three hundred twenty-two participants had a median age of 42 years (interquartile range, 32-49), an HIV duration of 9.4 years (2.7-17.4), and 58% were on highly active antiretroviral therapy (HAART). Overall, 102 patients (32%) became colonized with S aureus with an incidence rate of 20.6 (95% confidence interval [CI], 16.8-25.0) per 100 person-years [PYs]. Predictors of colonization in the final multivariable model included illicit drug use (hazard ratios [HR], 4.26; 95% CI, 1.33-13.69) and public gym use (HR 1.66, 95% CI, 1.04-2.66), whereas antibacterial soap use was protective (HR, 0.50; 95% CI, 0.32-0.78). In a separate model, perigenital colonization was associated with recent syphilis infection (HR, 4.63; 95% CI, 1.01-21.42). Fifteen percent of participants developed an SSTI (incidence rate of 9.4 cases [95% CI, 6.8-12.7] per 100 PYs). Risk factors for an SSTI included incident S aureus colonization (HR 2.52; 95% CI, 1.35-4.69), public shower use (HR, 2.59; 95% CI, 1.48-4.56), and hospitalization (HR 3.54; 95% CI, 1.67-7.53). The perigenital location for S aureus colonization was predictive of SSTIs. Human immunodeficiency virus-related factors (CD4 count, HIV RNA level, and HAART) were not associated with colonization or SSTIs.
Conclusions. Specific behaviors, but not HIV-related factors, are predictors of colonization and SSTIs. Behavioral modifications may be the most important strategies in preventing S aureus colonization and SSTIs among persons infected with HIV.
C1 [Crum-Cianflone, Nancy F.; Wang, Xun; Weintrob, Amy; Lalani, Tahaniyat; Bavaro, Mary; Okulicz, Jason F.; Mende, Katrin; Agan, Brian K.] Uniformed Serv Univ Hlth Sci, Infect Dis Clin Res Program, Bethesda, MD 20814 USA.
[Ellis, Michael] Uniformed Serv Univ Hlth Sci, Dept Med, Bethesda, MD 20814 USA.
[Crum-Cianflone, Nancy F.; Bavaro, Mary] Naval Med Ctr San Diego, Infect Dis Clin, San Diego, CA 92134 USA.
[Wang, Xun; Mende, Katrin; Agan, Brian K.] Henry M Jackson Fdn Adv Mil Med, Bethesda, MD USA.
[Weintrob, Amy] Walter Reed Army Med Ctr, Infect Dis Clin, Washington, DC 20307 USA.
[Lalani, Tahaniyat] Naval Med Ctr Portsmouth, Infect Dis Clin, Portsmouth, VA USA.
RP Crum-Cianflone, NF (reprint author), Naval Med Ctr San Diego, Clin Invest Dept KCA, 34800 Bob Wilson Dr,Ste 5, San Diego, CA 92134 USA.
EM nancy32red@yahoo.com
NR 41
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U1 2
U2 2
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 2328-8957
J9 OPEN FORUM INFECT DI
JI Open Forum Infect. Dis.
PD SPR
PY 2015
VL 2
IS 2
DI 10.1093/ofid/ofv034
PG 8
WC Infectious Diseases
SC Infectious Diseases
GA CX6BM
UT WOS:000365786200007
ER
PT J
AU Wang, HK
Haynes, R
Huang, HZ
Dong, LT
Atluri, SN
AF Wang, Hai-Kun
Haynes, Robert
Huang, Hong-Zhong
Dong, Leiting
Atluri, Satya N.
TI The Use of High-Performance Fatigue Mechanics and the Extended
Kalman/Particle Filters, for Diagnostics and Prognostics of Aircraft
Structures
SO CMES-COMPUTER MODELING IN ENGINEERING & SCIENCES
LA English
DT Article
DE Diagnostics and prognostics; fatigue mechanics; extended Kalman filter;
particle filter
ID ANALYSES SGBEM-FEM; ALTERNATING METHOD; SURFACE CRACKS; FRACTURE; GROWTH
AB In this paper, we propose an approach for diagnostics and prognostics of damaged aircraft structures, by combing high-performance fatigue mechanics with filtering theories. Fast & accurate deterministic analyses of fatigue crack propagations are carried out, by using the Finite Element Alternating Method (FEAM) for computing SIFs, and by using the newly developed Moving Least Squares (MLS) law for computing fatigue crack growth rates. Such algorithms for simulating fatigue crack propagations are embedded in the computer program Safe-Flaw, which is called upon as a subroutine within the probabilistic framework of filter theories. Both the extended Kalman as well as particle filters are applied in this study, to obtain the statistically optimal and semi-optimal estimates of crack lengths, from a series of noisy measurements of crack-lengths over time. For the specific problem, a simple modification to the particle filter, which can drastically reduce the computational burden, is also proposed. Based on the results of such diagnostic analyses, the prognostics of aerospace structures are thereafter achieved, to estimate the probabilistic distribution of the remaining useful life. By using a simple example of a single-crack near a fastener hole, we demonstrate the concept and effectiveness of the proposed framework. This paper thus forms the scientific foundation for the recently proposed concepts of VRAMS (Virtual Risk-Informed Agile Maneuver Sustainment) and Digital Twins of aerospace vehicles.
C1 [Wang, Hai-Kun; Huang, Hong-Zhong] Univ Elect Sci & Technol China, Sch Mech Elect & Ind Engn, Chengdu, Peoples R China.
[Wang, Hai-Kun; Dong, Leiting; Atluri, Satya N.] Univ Calif Irvine, Ctr Aerosp Res & Educ, Irvine, CA 92697 USA.
[Haynes, Robert] US Army Res Lab, Vehicle Technol Directorate, Adelphi, MD 20783 USA.
RP Dong, LT (reprint author), Univ Calif Irvine, Ctr Aerosp Res & Educ, Irvine, CA 92697 USA.
EM dong.leiting@gmail.com
RI Dong, Leiting /D-7970-2013
OI Dong, Leiting /0000-0003-1460-1846
FU Vehicle Technology Division of the Army Research Labs
FX This work, was supported by Vehicle Technology Division of the Army
Research Labs. The support and encouragement of Dy Le and Jaret Riddick
are thankfully acknowledged.
NR 20
TC 4
Z9 4
U1 1
U2 4
PU TECH SCIENCE PRESS
PI NORCROSS
PA 6825 JIMMY CARTER BLVD, STE 1850, NORCROSS, GA 30071 USA
SN 1526-1492
EI 1526-1506
J9 CMES-COMP MODEL ENG
JI CMES-Comp. Model. Eng. Sci.
PD MAR
PY 2015
VL 105
IS 1
BP 1
EP 24
PG 24
WC Engineering, Multidisciplinary; Mathematics, Interdisciplinary
Applications
SC Engineering; Mathematics
GA CT4TQ
UT WOS:000362800600001
ER
PT J
AU Vongsawan, AA
Kapatral, V
Vaisvil, B
Burd, H
Serichantalergs, O
Venkatesan, MM
Mason, CJ
AF Vongsawan, Ajchara A.
Kapatral, Vinayak
Vaisvil, Benjamin
Burd, Henry
Serichantalergs, Oralak
Venkatesan, Malabi M.
Mason, Carl J.
TI The genome of Shigella dysenteriae strain Sd1617 comparison to
representative strains in evaluating pathogenesis
SO FEMS MICROBIOLOGY LETTERS
LA English
DT Article
DE Shigella dysenteriae; genome; comparison
ID SHIGA-BACILLUS DYSENTERY; LOCUS PATHOGENICITY ISLAND; ESCHERICHIA-COLI;
CENTRAL-AMERICA; FLEXNERI 2A; O-ANTIGEN; SECRETION SYSTEMS; IN-VITRO;
PROTEIN; SEQUENCE
AB We sequenced and analyzed Shigella dysenteriae strain Sd1617 serotype 1 that is widely used as model strain for vaccine design, trials and research. A combination of next-generation sequencing platforms and assembly yielded two contigs representing a chromosome size of 4.34 Mb and the large virulence plasmid of 177 kb. This genome sequence is compared with other Shigella genomes in order to understand gene complexity and pathogenic factors.
C1 [Vongsawan, Ajchara A.; Serichantalergs, Oralak; Mason, Carl J.] Armed Forces Res Inst Med Sci, Dept Enter Dis, Bangkok 10400, Thailand.
[Kapatral, Vinayak; Vaisvil, Benjamin; Burd, Henry] Igenbio Inc, Chicago, IL 60607 USA.
[Venkatesan, Malabi M.] Walter Reed Army Inst Res, Div Bacterial & Rickettsial Dis, Silver Spring, MD 20910 USA.
RP Vongsawan, AA (reprint author), Armed Forces Res Inst Med Sci, Dept Enter Dis, 315-6 Rajvithi Rd, Bangkok 10400, Thailand.
EM ajcharataa@gmail.com
FU National Institute of Allergy and Infectious Diseases (NIAID) under IAA
[Y1-AI-4906-03]; US Army Medical Research and Materiel Command
(USAM-RMC)
FX This work was supported by the National Institute of Allergy and
Infectious Diseases (NIAID), under IAA # Y1-AI-4906-03, and by the US
Army Medical Research and Materiel Command (USAM-RMC).
NR 47
TC 2
Z9 2
U1 0
U2 0
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0378-1097
EI 1574-6968
J9 FEMS MICROBIOL LETT
JI FEMS Microbiol. Lett.
PD MAR
PY 2015
VL 362
IS 5
AR fnv011
DI 10.1093/femsle/fnv011
PG 8
WC Microbiology
SC Microbiology
GA CL3XN
UT WOS:000356885500012
ER
PT J
AU Ursano, RJ
Kessler, RC
Heeringa, SG
Cox, KL
Naifeh, JA
Fullerton, CS
Sampson, NA
Kao, TC
Aliaga, PA
Vegella, P
Mash, HH
Buckley, C
Colpe, LJ
Schoenbaum, M
Stein, MB
AF Ursano, Robert J.
Kessler, Ronald C.
Heeringa, Steven G.
Cox, Kenneth L.
Naifeh, James A.
Fullerton, Carol S.
Sampson, Nancy A.
Kao, Tzu-Cheg
Aliaga, Pablo A.
Vegella, Patti
Mash, Holly Herberman
Buckley, Christina
Colpe, Lisa J.
Schoenbaum, Michael
Stein, Murray B.
CA Army STARRS Collaborators
TI Nonfatal Suicidal Behaviors in US Army Administrative Records,
2004-2009: Results from the Army Study to Assess Risk and Resilience in
Servicemembers (Army STARRS)
SO PSYCHIATRY-INTERPERSONAL AND BIOLOGICAL PROCESSES
LA English
DT Article
ID MENTAL-DISORDERS; MILITARY; SOLDIERS; HOSPITALIZATIONS; SURVEILLANCE;
AFGHANISTAN; PREVALENCE; DEPRESSION; ADMISSIONS; INJURY
AB Objective: Although the U.S. Army suicide rate is known to have risen sharply over the past decade, information about medically documented, nonfatal suicidal behaviors is far more limited. Here we examine trends and sociodemographic correlates of suicide attempts, suspicious injuries, and suicide ideation among regular Army soldiers. Methods: Data come from the Army Study to Assess Risk and Resilience in Servicemembers (Army STARRS) Historical Administrative Data Study (HADS), which integrates administrative records for all soldiers on active duty during the years 2004 through 2009 (n = 1.66 million). Results: We identified 21,740 unique regular Army soldiers with a nonfatal suicidal event documented at some point during the HADS study period. There were substantial increases in the annual incidence rates of suicide attempts (179-400/100,000 person-years) and suicide ideation (557-830/100,000 person-years), but not suspicious injuries. Using hierarchical classification rules to identify the first instance of each soldier's most severe behavior, we found increased risk of all outcomes among those who were female, non-Hispanic White, never married, lower-ranking enlisted, less educated, and of younger age when entering Army service. These sociodemographic associations significantly differed across outcomes, despite some patterns that appear similar. Conclusion: Results provide a broad overview of nonfatal suicidal trends in the U.S. Army during 2004 through 2009 and demonstrate that integration of multiple administrative data systems enriches analysis of the predictors of such events.
C1 [Ursano, Robert J.; Naifeh, James A.; Fullerton, Carol S.; Aliaga, Pablo A.; Vegella, Patti; Mash, Holly Herberman; Buckley, Christina] Uniformed Serv Univ Hlth Sci, Dept Psychiat, Ctr Study Traumat Stress, Bethesda, MD 20814 USA.
[Kao, Tzu-Cheg] Uniformed Serv Univ Hlth Sci, Dept Prevent Med & Biometr, Bethesda, MD 20814 USA.
[Kessler, Ronald C.; Sampson, Nancy A.] Harvard Univ, Sch Med, Dept Hlth Care Policy, Boston, MA 02115 USA.
[Heeringa, Steven G.] Univ Michigan, Inst Social Res, Ann Arbor, MI USA.
[Cox, Kenneth L.] US Army Publ Hlth Command, Aberdeen Proving Ground, MD USA.
[Stein, Murray B.] Univ Calif San Diego, Dept Psychiat, La Jolla, CA 92093 USA.
[Stein, Murray B.] Univ Calif San Diego, Dept Family & Prevent Med, La Jolla, CA 92093 USA.
[Colpe, Lisa J.] Univ Calif San Diego, La Jolla, CA 92093 USA.
[Colpe, Lisa J.] VA San Diego Healthcare Syst, La Jolla, CA USA.
[Colpe, Lisa J.; Schoenbaum, Michael] NIMH, Bethesda, MD 20892 USA.
RP Ursano, RJ (reprint author), Uniformed Serv Univ Hlth Sci, Dept Psychiat, 4310 Jones Bridge Rd, Bethesda, MD 20814 USA.
EM robert.ursano@usuhs.edu
RI Wessely, Simon/A-8713-2008
FU Department of the Army; U.S. Department of Health and Human Services,
National Institutes of Health/National Institute of Mental Health
(NIH/NIMH) [U01MH087981]
FX Army STARRS was sponsored by the Department of the Army and funded under
cooperative agreement number U01MH087981 with the U.S. Department of
Health and Human Services, National Institutes of Health/National
Institute of Mental Health (NIH/NIMH). The contents are solely the
responsibility of the authors and do not necessarily represent the views
of the Department of Health and Human Services, NIMH, the Department of
the Army, or the Department of Defense. The Army STARRS Team consists of
Co Principal Investigators: Robert J. Ursano, MD (Uniformed Services
University of the Health Sciences), and Murray B. Stein, MD, MPH
(University of California San Diego and VA San Diego Healthcare System);
Site Principal Investigators: Steven Heeringa, PhD (University of
Michigan), and Ronald C. Kessler, PhD (Harvard Medical School); National
Institute of Mental Health (NIMH) collaborating scientists: Lisa J.
Colpe, PhD, MPH, and Michael Schoenbaum, PhD; Army liaisons/consultants:
COL Steven Cersovsky, MD, MPH (USAPHC), and Kenneth Cox, MD, MPH
(USAPHC); other team members: Pablo A. Aliaga, MA (Uniformed Services
University of the Health Sciences); COL David M. Benedek, MD (Uniformed
Services University of the Health Sciences); K. Nikki Benevides, MA
(Uniformed Services University of the Health Sciences); Susan Borja, PhD
(NIMH); Evelyn J. Bromet, PhD (Stony Brook University School of
Medicine); Gregory G. Brown, PhD (University of California San Diego);
Christina Buckley, BA (Uniformed Services University of the Health
Sciences); Laura Campbell-Sills, PhD (University of California San
Diego); Catherine L. Dempsey, PhD, MPH (Uniformed Services University of
the Health Sciences); Carol S. Fullerton, PhD (Uniformed Services
University of the Health Sciences); Nancy Gebler, MA (University of
Michigan); Robert K. Gifford, PhD (Uniformed Services University of the
Health Sciences); Stephen E. Gilman, ScD (Harvard School of Public
Health); Marjan G. Holloway, PhD (Uniformed Services University of the
Health Sciences); Paul E. Hurwitz, MPH (Uniformed Services University of
the Health Sciences); Sonia Jain, PhD (University of California San
Diego); Tzu-Cheg Kao, PhD (Uniformed Services University of the Health
Sciences); Karestan C. Koenen, PhD (Columbia University); Lisa
Lewandowski-Romps, PhD (University of Michigan); Holly Herberman Mash,
PhD (Uniformed Services University of the Health Sciences); James E.
McCarroll, PhD, MPH (Uniformed Services University of the Health
Sciences); James A. Naifeh, PhD (Uniformed Services University of the
Health Sciences); Tsz Hin Hinz Ng, MPH (Uniformed Services University of
the Health Sciences); Matthew K. Nock, PhD (Harvard University); Rema
Raman, PhD (University of California San Diego); Holly J. Ramsawh, PhD
(Uniformed Services University of the Health Sciences); Anthony Joseph
Rosellini, PhD (Harvard Medical School); Nancy A. Sampson, BA (Harvard
Medical School); LCDR Patcho Santiago, MD, MPH (Uniformed Services
University of the Health Sciences); Michaelle Scanlon, MBA (NINTH);
Jordan W. Smoller, MD, ScD (Harvard Medical School); Amy Street, PhD
(Boston University School of Medicine and VA Boston Healthcare System);
Michael L. Thomas, PhD (University of California San Diego); Patti L.
Vegella, MS, MA (Uniformed Services University of the Health Sciences);
Leming Wang, MS (Uniformed Services University of the Health Sciences);
Christina L. Wassel, PhD (University of Pittsburgh); Simon Wessely,
FMedSci (King's College London); Hongyan Wu, MPH (Uniformed Services
University of the Health Sciences); LTC Gary H.; Wynn, MD (Uniformed
Services University of the Health Sciences); Bailey G. Zhang, MS
(Uniformed Services University of the Health Sciences); and Alan M.
Zaslavsky, PhD (Harvard Medical School).
NR 50
TC 4
Z9 4
U1 1
U2 5
PU GUILFORD PUBLICATIONS INC
PI NEW YORK
PA 370 SEVENTH AVE, SUITE 1200, NEW YORK, NY 10001-1020 USA
SN 0033-2747
J9 PSYCHIATRY
JI Psychiatry-Interpers. Biol. Process.
PD SPR
PY 2015
VL 78
IS 1
BP 1
EP 21
DI 10.1080/00332747.2015.1006512
PG 21
WC Psychiatry
SC Psychiatry
GA CK6DN
UT WOS:000356318800001
PM 26168022
ER
PT J
AU Burmeister, DM
Becerra, S
Laborde, A
Natesan, S
Christy, RJ
AF Burmeister, D. M.
Becerra, S.
Laborde, A.
Natesan, S.
Christy, R. J.
TI PEGYLATED FIBRIN HYDROGELS FOR DELIVERY OF ADIPOSE-DERIVED STEM CELLS TO
DEEP-PARTIAL THICKNESS BURN WOUNDS
SO WOUND REPAIR AND REGENERATION
LA English
DT Meeting Abstract
C1 [Burmeister, D. M.; Becerra, S.; Laborde, A.; Natesan, S.; Christy, R. J.] US Army Inst Surg Res, Ft Sam Houston, TX USA.
NR 0
TC 0
Z9 0
U1 1
U2 2
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1067-1927
EI 1524-475X
J9 WOUND REPAIR REGEN
JI Wound Repair Regen.
PD MAR-APR
PY 2015
VL 23
IS 2
BP A17
EP A17
PG 1
WC Cell Biology; Dermatology; Medicine, Research & Experimental; Surgery
SC Cell Biology; Dermatology; Research & Experimental Medicine; Surgery
GA CK7YE
UT WOS:000356452000018
ER
PT J
AU Natesan, S
Baker, BA
Coronado, RE
Christy, RJ
AF Natesan, S.
Baker, B. A.
Coronado, R. E.
Christy, R. J.
TI HUMAN BLOOD PLASMA-DECELLULARIZED ADIPOSE TISSUE COMPOSITE WITH
MESENCHYMAL STEM CELLS CREATES A VASCULARIZED DERMAL SUBSTITUTE
SO WOUND REPAIR AND REGENERATION
LA English
DT Meeting Abstract
C1 [Natesan, S.; Baker, B. A.; Coronado, R. E.; Christy, R. J.] US Army Inst Surg Res, San Antionio, TX USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1067-1927
EI 1524-475X
J9 WOUND REPAIR REGEN
JI Wound Repair Regen.
PD MAR-APR
PY 2015
VL 23
IS 2
BP A33
EP A33
PG 1
WC Cell Biology; Dermatology; Medicine, Research & Experimental; Surgery
SC Cell Biology; Dermatology; Research & Experimental Medicine; Surgery
GA CK7YE
UT WOS:000356452000093
ER
PT J
AU Roy, D
Kowalczewski, C
Burmeister, D
Isaac, K
Burnett, L
Tomblyn, S
Christy, R
AF Roy, D.
Kowalczewski, C.
Burmeister, D.
Isaac, K.
Burnett, L.
Tomblyn, S.
Christy, R.
TI ANTIBIOTIC-LOADED KERATIN HYDROGELS PREVENT INFECTION IN A PORCINE
PARTIAL-THICKNESS THERMAL BURN
SO WOUND REPAIR AND REGENERATION
LA English
DT Meeting Abstract
C1 [Roy, D.; Kowalczewski, C.; Burmeister, D.; Isaac, K.; Christy, R.] US Army Inst Surg Res, Ft Sam Houston, TX USA.
[Roy, D.; Kowalczewski, C.; Burnett, L.; Tomblyn, S.] KeraNetics LLC, Winston Salem, NC USA.
RI Saul, Justin/I-1765-2016
NR 0
TC 0
Z9 0
U1 0
U2 2
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1067-1927
EI 1524-475X
J9 WOUND REPAIR REGEN
JI Wound Repair Regen.
PD MAR-APR
PY 2015
VL 23
IS 2
BP A37
EP A37
PG 1
WC Cell Biology; Dermatology; Medicine, Research & Experimental; Surgery
SC Cell Biology; Dermatology; Research & Experimental Medicine; Surgery
GA CK7YE
UT WOS:000356452000112
ER
PT J
AU Wehmeyer, JL
Friedrich, E
Natesan, S
Christy, R
AF Wehmeyer, J. L.
Friedrich, E.
Natesan, S.
Christy, R.
TI SCCO2-TREATED AMNIOTIC MEMBRANE-BASED EPITHELIAL SUBSTITUTE FOR
CUTANEOUS WOUND HEALING
SO WOUND REPAIR AND REGENERATION
LA English
DT Meeting Abstract
C1 [Wehmeyer, J. L.; Natesan, S.; Christy, R.] US Army Inst Surg Res, San Antonio, TX USA.
[Friedrich, E.] Carnegie Mellon, Pittsburgh, PA USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1067-1927
EI 1524-475X
J9 WOUND REPAIR REGEN
JI Wound Repair Regen.
PD MAR-APR
PY 2015
VL 23
IS 2
BP A44
EP A44
PG 1
WC Cell Biology; Dermatology; Medicine, Research & Experimental; Surgery
SC Cell Biology; Dermatology; Research & Experimental Medicine; Surgery
GA CK7YE
UT WOS:000356452000145
ER
PT J
AU Yen, NT
Liu, W
Hanh, HD
Chang, NY
Duong, TN
Gibbons, RV
Marks, F
Thu, NA
Hong, NM
Park, JK
Tuan, PA
Nisalak, A
Clemens, JD
Xu, ZY
AF Nguyen Thu Yen
Liu, Wei
Hoang Duc Hanh
Na Yoon Chang
Tran Nhu Duong
Gibbons, Robert V.
Marks, Florian
Nghiem Anh Thu
Nguyen Minh Hong
Park, Jin Kyung
Tuan, Pham Anh
Nisalak, Ananda
Clemens, John D.
Xu, Zhi-yi
TI A Model Immunization Programme to Control Japanese Encephalitis in Viet
Nam
SO JOURNAL OF HEALTH POPULATION AND NUTRITION
LA English
DT Article
DE Demonstration project; Effectiveness study; Immunization; Japanese
encephalitis; Vaccines
ID CEREBROSPINAL-FLUID; EPIDEMIOLOGY; VIRUS
AB In Viet Nam, an inactivated, mouse brain-derived vaccine for Japanese encephalitis (JE) has been given exclusively to <= 5 years old children in 3 paediatric doses since 1997. However, JE incidence remained high, especially among children aged 5-9 years. We conducted a model JE immunization programme to assess the feasibility and impact of JE vaccine administered to 1-9 year(s) children in 3 standard-dose regimen: paediatric doses for children aged < 3 years and adult doses for those aged >= 3 years. Of the targeted children, 96.2% were immunized with >= 2 doses of the vaccine. Compared to the national immunization programme, JE incidence rate declined sharply in districts with the model programme (11.32 to 0.87 per 100,000 in pre- versus post-vaccination period). The rate of reduction was most significant in the 5-9 years age-group. We recommend a policy change to include 5-9 years old children in the catch-up immunization campaign and administer a 4th dose to those aged 5-9 years, who had received 3 doses of the vaccine during the first 2-3 years of life.
C1 [Nguyen Thu Yen; Tran Nhu Duong; Nghiem Anh Thu; Nguyen Minh Hong; Tuan, Pham Anh] NIHE, Hanoi, Vietnam.
[Liu, Wei; Na Yoon Chang; Marks, Florian; Park, Jin Kyung; Clemens, John D.; Xu, Zhi-yi] Int Vaccine Inst, Seoul 151818, South Korea.
[Hoang Duc Hanh] Prevent Med Ctr, Hanoi, HaTay Province, Vietnam.
[Nisalak, Ananda] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand.
[Xu, Zhi-yi] Fudan Univ, Sch Publ Hlth, Dept Epidemiol, Shanghai 200433, Peoples R China.
RP Liu, W (reprint author), Int Vaccine Inst, Dept Translat Res, Seoul, South Korea.
EM wei_liu@post.harvard.edu
FU Korean International Cooperation Agency (KOICA) [2003-001]
FX Financial support for this project was provided by the Korean
International Cooperation Agency (KOICA) by contract no. 2003-001. The
authors thank colleagues from HaTay Provincial Hospital, and Hanoi
National Pediatric Hospital for their participation and contribution in
the investigation. We thank doctors working at the commune health
centres in HaTay for their help with the mass immunization campaign.
NR 15
TC 0
Z9 0
U1 0
U2 0
PU ICDDR B
PI DHAKA
PA MOHAKHALI, 1212 DHAKA, BANGLADESH
SN 1606-0997
EI 2072-1315
J9 J HEALTH POPUL NUTR
JI J. Heatlh Popul. Nutr.
PD MAR
PY 2015
VL 33
IS 1
BP 207
EP 213
PG 7
WC Environmental Sciences; Public, Environmental & Occupational Health
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
Health
GA CJ2AI
UT WOS:000355286100021
PM 25995736
ER
PT J
AU Yoon, EJ
Chabane, YN
Goussard, S
Snesrud, E
Courvalin, P
De, E
Grillot-Courvalin, C
AF Yoon, Eun-Jeong
Chabane, Yassine Nait
Goussard, Sylvie
Snesrud, Erik
Courvalin, Patrice
De, Emmanuelle
Grillot-Courvalin, Catherine
TI Contribution of Resistance-Nodulation-Cell Division Efflux Systems to
Antibiotic Resistance and Biofilm Formation in Acinetobacter baumannii
SO MBIO
LA English
DT Article
ID GRAM-NEGATIVE BACTERIA; MULTIDRUG-RESISTANCE; GENOME SEQUENCE; MULTIPLE
ANTIBIOTICS; ESCHERICHIA-COLI; ABIOTIC SURFACES; VIBRIO-CHOLERAE;
SUICIDE VECTOR; PUMPS; ADEIJK
AB Acinetobacter baumannii is a nosocomial pathogen of increasing importance due to its multiple resistance to antibiotics and ability to survive in the hospital environment linked to its capacity to form biofilms. To fully characterize the contribution of AdeABC, AdeFGH, and AdeIJK resistance-nodulation-cell division (RND)-type efflux systems to acquired and intrinsic resistance, we constructed, from an entirely sequenced susceptible A. baumannii strain, a set of isogenic mutants overexpressing each system following introduction of a point mutation in their cognate regulator or a deletion for the pump by allelic replacement. Pairwise comparison of every derivative with the parental strain indicated that AdeABC and AdeFGH are tightly regulated and contribute to acquisition of antibiotic resistance when overproduced. AdeABC had a broad substrate range, including beta-lactams, fluoroquinolones, tetracyclines-tigecycline, macrolides-lincosamides, and chloramphenicol, and conferred clinical resistance to aminoglycosides. Importantly, when combined with enzymatic resistance to carbapenems and aminoglycosides, this pump contributed in a synergistic fashion to the level of resistance of the host. In contrast, AdeIJK was expressed constitutively and was responsible for intrinsic resistance to the same major drug classes as AdeABC as well as antifolates and fusidic acid. Surprisingly, overproduction of AdeABC and AdeIJK altered bacterial membrane composition, resulting in decreased biofilm formation but not motility. Natural transformation and plasmid transfer were diminished in recipients overproducing AdeABC. It thus appears that alteration in the expression of efflux systems leads to multiple changes in the relationship between the host and its environment, in addition to antibiotic resistance.
IMPORTANCE Increased expression of chromosomal genes for RND-type efflux systems plays a major role in bacterial multidrug resistance. Acinetobacter baumannii has recently emerged as an important human pathogen responsible for epidemics of hospital-acquired infections. Besides its remarkable ability to horizontally acquire resistance determinants, it has a broad intrinsic resistance due to low membrane permeability, endogenous resistance genes, and antibiotic efflux. The study of isogenic mutants from a susceptible A. baumannii clinical isolate overproducing or deleted for each of the three major RND-type pumps demonstrated their major contribution to intrinsic resistance and to the synergism between overproduction of an efflux system and acquisition of a resistance gene. We have also shown that modulation of expression of the structural genes for the efflux systems results in numerous alterations in membrane-associated cellular functions, in particular, in a decrease in biofilm formation and resistance gene acquisition.
C1 [Yoon, Eun-Jeong; Goussard, Sylvie; Courvalin, Patrice; Grillot-Courvalin, Catherine] Inst Pasteur, Unite Agents Antibacteriens, Paris, France.
[Chabane, Yassine Nait; De, Emmanuelle] Univ Rouen, Lab Polymeres, Biopolymeres, Surfaces,UMR 6270, Mont St Aignan, France.
[Chabane, Yassine Nait; De, Emmanuelle] Univ Rouen, IRIB, FR CNRS 3038, Mont St Aignan, France.
[Snesrud, Erik] Walter Reed Army Inst Res, Multidrug Resistant Organism Repository & Surveil, Silver Spring, MD USA.
RP Grillot-Courvalin, C (reprint author), Inst Pasteur, Unite Agents Antibacteriens, Paris, France.
EM ccourval@pasteur.fr
FU Reckitt-Benckiser
FX E.-J.Y. was supported by an unrestricted grant from Reckitt-Benckiser.
NR 60
TC 21
Z9 22
U1 3
U2 15
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 2150-7511
J9 MBIO
JI mBio
PD MAR-APR
PY 2015
VL 6
IS 2
AR e00309-15
DI 10.1128/mBio.00309-15
PG 13
WC Microbiology
SC Microbiology
GA CJ2KE
UT WOS:000355312400100
ER
PT J
AU Goodson, LP
AF Goodson, Larry P.
TI The US and Afghanistan after 2014
SO ASIAN SURVEY
LA English
DT Article
DE Afghanistan; US interests, policies, and strategies; Great Game;
Taliban; insurgency
AB The attacks of 9/11 spurred the U.S. to pursue national security interests in Afghanistan through expensive, overlapping strategies. The Afghan War helped elicit changes in the region that produced new American interests there. Because of a modern "Great Game" between regional and global actors in and around Afghanistan, the U.S. cannot afford to withdraw from the region.
C1 US Army War Coll, Middle East Studies, Carlisle, PA 17013 USA.
RP Goodson, LP (reprint author), US Army War Coll, Middle East Studies, Carlisle, PA 17013 USA.
EM larry.p.goodson.civ@mail.mil
NR 35
TC 0
Z9 0
U1 1
U2 5
PU UNIV CALIFORNIA PRESS
PI OAKLAND
PA 155 GRAND AVE, SUITE 400, OAKLAND, CA 94612-3758 USA
SN 0004-4687
EI 1533-838X
J9 ASIAN SURV
JI Asian Surv.
PD MAR-APR
PY 2015
VL 55
IS 2
BP 249
EP 272
DI 10.1525/AS.2.015.55.2.249
PG 24
WC Area Studies
SC Area Studies
GA CI3RE
UT WOS:000354664300002
ER
PT J
AU Baral, SD
Ketende, S
Schwartz, S
Orazulike, I
Ugoh, K
Peel, SA
Ake, J
Blattner, W
Charurat, M
AF Baral, Stefan D.
Ketende, Sosthenes
Schwartz, Sheree
Orazulike, Ifeanyi
Ugoh, Kelechi
Peel, Sheila A.
Ake, Julie
Blattner, William
Charurat, Manhattan
CA TRUST Study Grp
TI Evaluating Respondent-Driven Sampling as an Implementation Tool for
Universal Coverage of Antiretroviral Studies Among Men Who Have Sex With
Men Living With HIV
SO JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES
LA English
DT Article
DE Antiretroviral treatment; HIV; men who have sex with men; Nigeria;
Africa; Respondent-driven sampling
ID TRANSGENDER WOMEN; UNITED-STATES; BLACK-MEN; PREVENTION; TRANSMISSION;
INFECTION; EPIDEMIOLOGY; POPULATIONS; CHALLENGES; INITIATION
AB Introduction: The TRUST model based on experimental and observational data posits that integration of HIV prevention and universal coverage of antiretroviral treatment at a trusted community venue provides a framework for achieving effective reduction in HIV-related morbidity and mortality among men who have sex with men (MSM) living with HIV, as well as reducing HIV incidence. The analyses presented here evaluate the utility of respondent-driven sampling as an implementation tool for engaging MSM in the TRUST intervention.
Methods: The TRUST integrated prevention and treatment model was established at a trusted community center serving MSM in Abuja, Nigeria. Five seeds have resulted in 3-26 waves of accrual between March 2013 and August 2014, with results presented here characterizing HIV burden and engagement in HIV care for 722 men across study recruitment waves. For analytic purposes, the waves were collapsed into 5 groups: 4 equally spaced (0-4, 5-9, 10-14, and 15-19) and 1 ranging from the 20th to the 26th wave with significance assessed using Pearson chi(2) test.
Results: In earlier waves, MSM were more likely to have reported testing for HIV (82.9% in waves 0-4, 47.7% in waves 20-26; P < 0.01). In addition, biologically confirmed HIV prevalence decreased from an average of 59.1% to 42.9% (P < 0.05) in later waves. In earlier waves, about 80% of participants correctly reported their HIV status as compared with less than 25% in the later waves (P < 0.01). Finally, participants reporting being on ART decreased from 50% to 22.2% in later waves (P < 0.01).
Conclusions: Implementation science studies focused on demonstrating impact of universal HIV treatment programs among people living with HIV necessitate different accrual methods than those focused on preventing HIV acquisition. Here, respondent-driven sampling was shown to be an efficient method for reaching marginalized populations of MSM living with HIV in Nigeria, and engaging them in universal HIV treatment services.
C1 [Baral, Stefan D.; Ketende, Sosthenes; Schwartz, Sheree] JHSPH, Key Populat Program, Ctr Publ Hlth & Human Rights, Dept Epidemiol, Baltimore, MD USA.
[Orazulike, Ifeanyi] ICARH, Abuja, Nigeria.
[Ugoh, Kelechi] Improving Mens Hlth Initiat, Abuja, Nigeria.
[Peel, Sheila A.; Ake, Julie] US Mil HIV Res Project, Silver Spring, MD USA.
[Peel, Sheila A.; Ake, Julie] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD USA.
[Blattner, William; Charurat, Manhattan] Univ Maryland, Div Epidemiol & Prevent, Baltimore, MD 21201 USA.
RP Baral, SD (reprint author), E7146,615 N Wolfe St, Baltimore, MD 21205 USA.
EM sbaral@jhu.edu
FU US National Institutes of Health [R01MH099001-01]; US Military HIV
Research Program [W81XWH-07-2-0067]; Fogarty AITRP [D43TW01041];
HHS/Centers for Disease Control and Prevention (CDC), Global AIDS
Program [U2G IPS000651]; IHVN; Johns Hopkins University Center for AIDS
Research [P30AI094189]
FX Supported by the US National Institutes of Health under award number
R01MH099001-01. This study is also supported by funds from the US
Military HIV Research Program (Grant No. W81XWH-07-2-0067), Fogarty
AITRP (D43TW01041), and the President's Emergency Plan for AIDS Relief
through cooperative agreement U2G IPS000651 from the HHS/Centers for
Disease Control and Prevention (CDC), Global AIDS Program with IHVN.
Support provided to SB by the Johns Hopkins University Center for AIDS
Research (P30AI094189).
NR 39
TC 8
Z9 8
U1 1
U2 5
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1525-4135
EI 1077-9450
J9 JAIDS-J ACQ IMM DEF
JI JAIDS
PD MAR 1
PY 2015
VL 68
SU 2
BP S107
EP S113
PG 7
WC Immunology; Infectious Diseases
SC Immunology; Infectious Diseases
GA CH6CJ
UT WOS:000354123100006
PM 25723974
ER
PT J
AU Abuzneid, AS
Sobh, T
Faezipour, M
Mahmood, A
James, J
AF Abuzneid, Abdel-Shakour
Sobh, Tarek
Faezipour, Miad
Mahmood, Ausif
James, John
TI Fortified Anonymous Communication Protocol for Location Privacy in WSN:
A Modular Approach
SO SENSORS
LA English
DT Article
DE WSN; anonymity; privacy; source location privacy; sink privacy;
contextual privacy; routing privacy; temporal privacy; traffic privacy;
observability; safety period
ID WIRELESS SENSOR NETWORKS; INTERNET; THINGS
AB Wireless sensor network (WSN) consists of many hosts called sensors. These sensors can sense a phenomenon (motion, temperature, humidity, average, max, min, etc.) and represent what they sense in a form of data. There are many applications for WSNs including object tracking and monitoring where in most of the cases these objects need protection. In these applications, data privacy itself might not be as important as the privacy of source location. In addition to the source location privacy, sink location privacy should also be provided. Providing an efficient end-to-end privacy solution would be a challenging task to achieve due to the open nature of the WSN. The key schemes needed for end-to-end location privacy are anonymity, observability, capture likelihood, and safety period. We extend this work to allow for countermeasures against multi-local and global adversaries. We present a network model protected against a sophisticated threat model: passive /active and local/multi-local/global attacks. This work provides a solution for end-to-end anonymity and location privacy as well. We will introduce a framework called fortified anonymous communication (FAC) protocol for WSN.
C1 [Abuzneid, Abdel-Shakour; Sobh, Tarek; Faezipour, Miad; Mahmood, Ausif] Univ Bridgeport, Comp Sci & Engn Dept, Bridgeport, CT 06604 USA.
[James, John] US Mil Acad, Dept Elect Engn & Comp Sci, West Point, NY 10996 USA.
RP Abuzneid, AS (reprint author), Univ Bridgeport, Comp Sci & Engn Dept, Bridgeport, CT 06604 USA.
EM abuzneid@bridgeport.edu; sobh@bridgeport.edu; mfaezipo@bridgeport.edu;
Mahmood@bridgeport.edu; john.james@usma.edu
NR 49
TC 5
Z9 5
U1 1
U2 18
PU MDPI AG
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1424-8220
J9 SENSORS-BASEL
JI Sensors
PD MAR
PY 2015
VL 15
IS 3
BP 5820
EP 5864
DI 10.3390/s150305820
PG 45
WC Chemistry, Analytical; Electrochemistry; Instruments & Instrumentation
SC Chemistry; Electrochemistry; Instruments & Instrumentation
GA CH6QK
UT WOS:000354160900064
PM 25763649
ER
PT J
AU Lim, R
AF Lim, Robert
TI Comment on: Laparoscopic sleeve gastrectomy in patients over 60 years:
impact of age on weight loss and co-morbidity improvement
SO SURGERY FOR OBESITY AND RELATED DISEASES
LA English
DT Editorial Material
C1 Tripler Army Med Ctr, Dept Surg, Honolulu, HI 96859 USA.
RP Lim, R (reprint author), Tripler Army Med Ctr, Dept Surg, Honolulu, HI 96859 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1550-7289
EI 1878-7533
J9 SURG OBES RELAT DIS
JI Surg. Obes. Relat. Dis.
PD MAR-APR
PY 2015
VL 11
IS 2
BP 301
EP 302
PG 2
WC Surgery
SC Surgery
GA CI0HU
UT WOS:000354418500009
PM 25066160
ER
PT J
AU Theiling, CH
Janvrin, JA
Hendrickson, J
AF Theiling, Charles H.
Janvrin, Jeffrey A.
Hendrickson, Jon
TI Upper Mississippi River restoration: implementation, monitoring, and
learning since 1986
SO RESTORATION ECOLOGY
LA English
DT Article
DE adaptive management; backwater; habitat suitability model; island;
wetland
ID CONNECTIVITY; MANAGEMENT; FISH; POPULATION; BACKWATERS; WATERFOWL;
ILLINOIS; HABITAT; SYSTEM; OXYGEN
AB Upper Mississippi River Restoration (UMRR) was implemented to monitor environmental status and trends and restore degraded habitat. There was little experience conducting restoration in large rivers, and engineering and ecological integration evolved through project implementation. Loss of depth in backwaters and side channels, excessive biological oxygen demand, increased currents, and low water temperatures were common symptoms of backwater eutrophication that were primary objectives for implementing UMRR. Biological outcome monitoring was initially funded for six projects using the most common methods to restore aquatic and wetland habitat. UMRR island construction occurred as four generations of learning. Current plans represent a comprehensive restoration approach including: physical process modeling (i.e. hydraulic and wind-wave modeling) of existing conditions and alternative restoration measures. Habitat Rehabilitation and Enhancement Projects, fish response monitoring validated winter habitat suitability models. Long term fish population monitoring indicates sustainable recovery, and now population interaction among restored lakes is under investigation. Isolated wetland management in Illinois River backwater lakes can achieve bottom consolidation that promotes emergent wetland habitat response that migratory waterfowl exploit in large numbers. Adult fish movement between the river and management units is restricted to flood stage or through control structures and post-project movements into the lake for overwintering were not apparent. The lack of Illinois River overwintering habitat is shown by an abundance of young fish and few older fish in status and trends monitoring. Upper Mississippi River System ecosystem restoration practitioners have implemented ecosystem restoration science and practice in a manner that exemplifies the best intent of adaptive management.
C1 [Theiling, Charles H.] US Army, Corps Engineers, Rock Isl, IL 61204 USA.
[Janvrin, Jeffrey A.] Wisconsin Dept Nat Resources, La Crosse, WI 54601 USA.
[Hendrickson, Jon] US Army, Corps Engineers, St Paul, MN 55101 USA.
RP Theiling, CH (reprint author), US Army, Corps Engineers, Rock Isl, IL 61204 USA.
EM charles.h.theiling@usace.army.mil
FU U.S. Army Corps of Engineers, Upper Mississippi River Restoration
FX U.S. Army Corps of Engineers, Upper Mississippi River Restoration has
supported restoration, monitoring, and science for over 25 years and
contributed financial support for this review.
NR 49
TC 6
Z9 6
U1 5
U2 33
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1061-2971
EI 1526-100X
J9 RESTOR ECOL
JI Restor. Ecol.
PD MAR
PY 2015
VL 23
IS 2
BP 157
EP 166
DI 10.1111/rec.12170
PG 10
WC Ecology
SC Environmental Sciences & Ecology
GA CH3WU
UT WOS:000353962500009
ER
PT J
AU Nottage, D
Corns, S
Soylemezoglu, A
Kinnevan, K
AF Nottage, Dustin
Corns, Steven
Soylemezoglu, Ahmet
Kinnevan, Kurt
TI A SysML Framework for Modeling Contingency Basing
SO SYSTEMS ENGINEERING
LA English
DT Article
DE model-based systems engineering; OMG SysML; contingency basing
AB Contingency basing presents a planner with numerous design decisions driven by multiple design criteria such as the number of soldiers, base permanency, base location, and other factors. The operational environment of the base is not static either; design requirements change as the mission changes. In this work, we introduce a model-based systems engineering approach to elicit design and operational needs while dealing with the design complexity of constructing a contingency base. The model includes the key facility types that can make a contingency base, interactions between facility types, and required utilities for each facility type. The model elements are kept at an abstract level so the details can be altered as required by the customer needs. Pairing the model with an external analysis tool allows for quick development and testing. Properties of the facility types can be altered either in the model or the analysis tool, and reflected in both. Using the model-based systems engineering concepts of reusability, these elements can be saved and re-used in future base designs allowing for a rapid and adaptable design process. In addition, the sharing of information visually with Object Management Group's Systems Modeling Language (TM) diagrams enhances the ability to collaborate with nonengineering subject matter experts within the design domain. By graphically showing the conditions and layout of the proposed contingency base, Department of Defense personnel not trained in modeling and simulation were able to interact with the engineering designs and identify gaps in the proposed architecture. (C) 2015 Wiley Periodicals, Inc.
C1 [Nottage, Dustin; Corns, Steven] Missouri Univ Sci & Technol, Engn Management & Syst Engn, Rolla, MO 65409 USA.
[Soylemezoglu, Ahmet; Kinnevan, Kurt] Engineer Res & Dev Ctr, Construct Engn Res Lab, Champaign, IL 61826 USA.
RP Corns, S (reprint author), Missouri Univ Sci & Technol, Engn Management & Syst Engn, 223 EMGT Bldg, Rolla, MO 65409 USA.
EM cornss@mst.edu
NR 33
TC 0
Z9 0
U1 2
U2 13
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1098-1241
EI 1520-6858
J9 SYSTEMS ENG
JI Syst. Eng.
PD MAR
PY 2015
VL 18
IS 2
BP 162
EP 177
DI 10.1002/sys.21297
PG 16
WC Engineering, Industrial; Operations Research & Management Science
SC Engineering; Operations Research & Management Science
GA CI3AQ
UT WOS:000354620200004
ER
PT J
AU Steele, SR
Varma, MG
Prichard, D
Bharucha, AE
Vogler, SA
Erdogan, A
Rao, SSC
Lowry, AC
Lange, EO
Hall, GM
Bleier, JIS
Senagore, AJ
Maykel, J
Chan, SY
Paquette, IM
Audett, MC
Bastawrous, A
Umamaheswaran, P
Fleshman, JW
Caton, G
O'Brien, BS
Nelson, JM
Steiner, A
Garely, A
Noor, N
Desrosiers, L
Kelley, R
Jacobson, NS
Rahimi, S
AF Steele, Scott R.
Varma, Madhulika G.
Prichard, David
Bharucha, Adil E.
Vogler, Sarah A.
Erdogan, Askin
Rao, Satish S. C.
Lowry, Ann C.
Lange, Erin O.
Hall, Glen M.
Bleier, Joshua I. S.
Senagore, Anthony J.
Maykel, Justin
Chan, Sook Y.
Paquette, Ian M.
Audett, Marie C.
Bastawrous, Amir
Umamaheswaran, Preetha
Fleshman, James W.
Caton, Gentry
O'Brien, Brendan S.
Nelson, Jeffery M.
Steiner, Ari
Garely, Alan
Noor, Nabila
Desrosiers, Laurephile
Kelley, Robert
Jacobson, Nina S.
Rahimi, Salma
TI The evolution of evaluation and management of urinary or fecal
incontinence and pelvic organ prolapse
SO CURRENT PROBLEMS IN SURGERY
LA English
DT Review
ID LAPAROSCOPIC VENTRAL RECTOPEXY; EXTERNAL RECTAL PROLAPSE; PERINEAL
STAPLED PROLAPSE; QUALITY-OF-LIFE; POSTERIOR VAGINAL COMPARTMENT;
COST-EFFECTIVENESS ANALYSIS; SACRAL NERVE-STIMULATION; LONG-TERM;
SURGICAL-MANAGEMENT; ABDOMINAL RECTOPEXY
C1 [Steele, Scott R.] Uniformed Serv Univ Hlth Sci, Surg, Ft Lewis, WA 98433 USA.
[Steele, Scott R.] Madigan Army Med Ctr, Colon & Rectal Surg, Ft Lewis, WA USA.
[Varma, Madhulika G.] Univ Calif San Francisco, Sect Colorectal Surg, San Francisco, CA 94143 USA.
[Prichard, David] Mayo Clin, GI Motil, Rochester, MN USA.
[Bharucha, Adil E.] Mayo Clin, Med, Rochester, MN USA.
[Vogler, Sarah A.] Univ Minnesota, Surg, Edina, MN USA.
[Erdogan, Askin] Georgia Regents Univ, Augusta, GA USA.
[Rao, Satish S. C.] Georgia Regents Univ, Digest Hlth Ctr, Augusta, GA USA.
[Lowry, Ann C.] Univ Minnesota, Surg, St Paul, MN 55108 USA.
[Lange, Erin O.] Univ Washington, Surg, Seattle, WA 98195 USA.
[Hall, Glen M.] Case Western Reserve Univ, Cleveland, OH 44106 USA.
[Bleier, Joshua I. S.] Univ Penn, Perelman Sch Med, Surg, Philadelphia, PA 19104 USA.
[Senagore, Anthony J.] Case Western Reserve Univ, Sch Med, Dept Surg, Cleveland, OH 44106 USA.
[Maykel, Justin; Chan, Sook Y.] Univ Massachusetts, Mem Med Ctr, Dept Surg, Worcester, MA 01605 USA.
[Paquette, Ian M.] Univ Cincinnati, Coll Med, Dept Surg, Surg, Cincinnati, OH USA.
[Audett, Marie C.] Univ Cincinnati, Coll Med, Dept Surg, Cincinnati, OH USA.
[Umamaheswaran, Preetha] Swedish Med Ctr, Colon & Rectal Surg, Seattle, WA USA.
[Fleshman, James W.] Baylor Univ, Med Ctr, Dept Surg, Dallas, TX 75246 USA.
[Caton, Gentry] Baylor Univ, Med Ctr, Colon & Rectal Surg, Dallas, TX USA.
[O'Brien, Brendan S.] US Navy, Med Corps, LT, Dept Surg,Walter Reed Natl Mil Med Ctr, Washington, DC USA.
[Nelson, Jeffery M.] US Army, COL, MC, Dept Surg,Walter Reed Natl Mil Med Ctr, Bethesda, MD USA.
[Steiner, Ari] South Nassau Commun Hosp, Radiol, Oceanside, NY USA.
[Garely, Alan] Icahn Sch Med Mt Sinai, Obstet Gynecol & Reprod Med, New York, NY 10029 USA.
[Noor, Nabila] Icahn Sch Med Mt Sinai, Obstet & Gynecol, New York, NY 10029 USA.
[Desrosiers, Laurephile; Kelley, Robert; Jacobson, Nina S.] Icahn Sch Med Mt Sinai, Female Pelv Med & Reconstruct Surg, New York, NY 10029 USA.
[Rahimi, Salma] Mt Sinai Hosp, Obstet & Gynecol, New York, NY 10029 USA.
RP Steele, SR (reprint author), Uniformed Serv Univ Hlth Sci, Surg, Ft Lewis, WA 98433 USA.
NR 163
TC 3
Z9 3
U1 0
U2 6
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0011-3840
EI 1535-6337
J9 CURR PROB SURG
JI Curr. Probl. Surg.
PD MAR
PY 2015
VL 52
IS 3
BP 92
EP 136
DI 10.1067/j.cpsurg.2015.02.001
PG 45
WC Surgery
SC Surgery
GA CH5KC
UT WOS:000354073500002
PM 25933741
ER
PT J
AU Jain, RB
AF Jain, Ram B.
TI Association of arsenic exposure with smoking, alcohol, and caffeine
consumption: Data from NHANES 2005-2010
SO ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
LA English
DT Article
DE Gender; Age; Race/ethnicity; Arsenobetaine; Dimethylarsonic acid
ID CARDIOVASCULAR-DISEASE; DRINKING-WATER; RISK; CANCER; POPULATION;
CIGARETTES; TOBACCO; BANGLADESH; SPECIATION; WORKERS
AB Association of arsenic exposure with smoking, alcohol, and caffeine consumption was investigated. Data from National Health and Nutrition Examination Survey for the years 2005-2010 were used for this investigation. Urinary levels of total arsenic (UAS) and dimethylarsonic acid (UDMA) were evaluated for children aged 6-12 years and adolescents and adults aged >= 12 years. Urinary levels of arsenobetaine (UAB) were evaluated for adolescents and adults only. Regression models were fitted for log transformed values of UAB, UAS, and UDMA. For the models for children, however, gender, race/ethnicity, SES, and fish/shell fish consumption during the last 30 days were the only independent variables that were included in the models. Nonsmokers were found to have higher levels of UAS and UDMA than smokers. Elevated levels of UAB, UAS, and UDMA were associated with higher amounts of daily alcohol consumption. The associations were in the opposite direction for daily caffeine consumption. Females were found to have statistically significantly lower adjusted levels of UDMA than males for those aged >= 12 years. Irrespective of age, those with unclassified race/ethnicity had the highest levels of UAB, UAS, and UDMA and non-Hispanic whites had the lowest levels. Adolescents had the higher levels of UAB, UAS, and UDMA than adults. Higher SES was associated with higher levels of UAB, UAS, and UDMA among adolescents and adults. Irrespective of age, fish consumption was associated with higher levels of UAB, UAS, and UDMA. Published by Elsevier B.V.
C1 [Jain, Ram B.] Womack Army Med Ctr, Ft Bragg, NC 28310 USA.
[Jain, Ram B.] Empiristat Inc, Mt Airy, MD USA.
RP Jain, RB (reprint author), Womack Army Med Ctr, Dept Clin Invest, Ft Bragg, NC 28310 USA.
EM ram.b.jain.ctr@mail.mil
NR 28
TC 2
Z9 2
U1 2
U2 5
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1382-6689
EI 1872-7077
J9 ENVIRON TOXICOL PHAR
JI Environ. Toxicol. Pharmacol.
PD MAR
PY 2015
VL 39
IS 2
BP 651
EP 658
DI 10.1016/j.etap.2015.01.011
PG 8
WC Environmental Sciences; Pharmacology & Pharmacy; Toxicology
SC Environmental Sciences & Ecology; Pharmacology & Pharmacy; Toxicology
GA CH3KP
UT WOS:000353929900020
PM 25682010
ER
PT J
AU Jain, RB
AF Jain, Ram B.
TI Levels of caffeine and its metabolites among US smokers and nonsmokers
SO ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
LA English
DT Article
DE Caffeine intake; Race/ethnicity; Smoking; CYP1A2
ID TYPE-2 DIABETES-MELLITUS; DOSE-RESPONSE METAANALYSIS; COFFEE
CONSUMPTION; BLOOD-PRESSURE; PARKINSONS-DISEASE; PROSPECTIVE COHORT;
LIVER-CIRRHOSIS; CYP1A2 ACTIVITY; HEART-DISEASE; RISK
AB Data from National Health and Nutrition Examination Survey for the years 2009-2010 were used to estimate the levels of caffeine and 14 of its metabolite among U.S. smokers and nonsmokers after adjustments were made for other factors that affect observed caffeine levels. In this study, when adjusted for daily caffeine intake, adjusted levels (AGM) of caffeine and its metabolites were not found to be statistically significantly different between smokers and nonsmokers. AGMs for caffeine and all of its metabolites were found to be statistically significantly higher (p < 0.01) among females aged >= 12 years than males. For caffeine, 1,3-dimethylxanthine, and 1,7-dimethylxanthine, those aged >= 20 years had statistically significantly higher (p < 0.01) AGM than those aged 12-19 years but the reverse was true for 7-methylxanthine and 3,7-dimethylxanthine (p <= 0.02). The order of the AGMs by race/ethnicity was non-Hispanic whites > Hispanics > non-Hispanic blacks and most of the differences were statistically significant, at least between non-Hispanic whites and non-Hispanic blacks (p < 0.01). In general, there was a statistically significant positive association between the levels of caffeine and its metabolites and body mass index as well as daily caffeine intake. However, the levels of 7-methylxanthine were negatively associated with body mass index. (C) 2015 Elsevier B.V. All rights reserved.
C1 [Jain, Ram B.] Womack Army Med Ctr, Ft Bragg, NC 28310 USA.
[Jain, Ram B.] Empiristat Inc, Mt Airy, MD USA.
RP Jain, RB (reprint author), Womack Army Med Ctr, Dept Clin Invest, 2817 Reilly Rd, Ft Bragg, NC 28310 USA.
EM ram.b.jain.ctr@mail.mil
NR 44
TC 0
Z9 0
U1 1
U2 6
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1382-6689
EI 1872-7077
J9 ENVIRON TOXICOL PHAR
JI Environ. Toxicol. Pharmacol.
PD MAR
PY 2015
VL 39
IS 2
BP 773
EP 786
DI 10.1016/j.etap.2015.02.002
PG 14
WC Environmental Sciences; Pharmacology & Pharmacy; Toxicology
SC Environmental Sciences & Ecology; Pharmacology & Pharmacy; Toxicology
GA CH3KP
UT WOS:000353929900034
PM 25733129
ER
PT J
AU Chan, MK
Krebs, MO
Cox, D
Guest, P
Yolked, R
Rahmoune, H
Rothermundt, M
Steiner, J
Leweke, FM
Van Beveren, NJM
Niebuhr, DW
Webers, NS
Cowan, DN
Suarez-Pinilla, P
Crespo-Facorro, B
Mam-Lam-Fook, C
Bourgin, J
Wenstrup, RJ
Kaldate, RR
Cooper, JD
Bahn, S
AF Chan, Man Kuan
Krebs, Marie Odile
Cox, David
Guest, Paul
Yolken, Robert
Rahmoune, Hassan
Rothermundt, Matthias
Steiner, Johann
Leweke, F. Markus
Van Beveren, Nico J. M.
Niebuhr, David W.
Webers, Natalya S.
Cowan, David N.
Suarez-Pinilla, Paula
Crespo-Facorro, Benedicto
Mam-Lam-Fook, Celia
Bourgin, Julie
Wenstrup, Richard J.
Kaldate, Rajesh R.
Cooper, Jason D.
Bahn, Sabine
TI DEVELOPMENT OF A BLOOD-BASED MOLECULAR BIOMARKER TEST FOR IDENTIFICATION
OF SCHIZOPHRENIA PRIOR TO DISEASE ONSET
SO SCHIZOPHRENIA BULLETIN
LA English
DT Meeting Abstract
CT 15th International Congress on Schizophrenia Research (ICOSR)
CY MAR 28-APR 01, 2015
CL Colorado Springs, CO
C1 [Chan, Man Kuan; Cox, David; Guest, Paul; Rahmoune, Hassan; Cooper, Jason D.; Bahn, Sabine] Univ Cambridge, Dept Chem Engn & Biotechnol, Cambridge, England.
[Krebs, Marie Odile; Mam-Lam-Fook, Celia; Bourgin, Julie] Univ Paris 05, Sorbonne Cite, INSERM, Lab Physiopathol Malad Psychiat, Paris, France.
[Yolken, Robert] Johns Hopkins Univ, Sch Med, Baltimore, MD USA.
[Rothermundt, Matthias] Univ Munster, D-48149 Munster, Germany.
[Steiner, Johann] Univ Magdeburg, Dept Psychiat, D-39106 Magdeburg, Germany.
[Leweke, F. Markus] Heidelberg Univ, Cent Inst Mental Hlth, Med Fac Mannheim, Mannheim, Germany.
[Van Beveren, Nico J. M.] Erasmus MC, Dept Neurosci, Rotterdam, Netherlands.
[Niebuhr, David W.; Webers, Natalya S.; Cowan, David N.] Walter Reed Army Inst Res, Silver Spring, MD USA.
[Suarez-Pinilla, Paula; Crespo-Facorro, Benedicto] Univ Cantabria, IDIVAL, CIBERSAM, Univ Hosp Marques Valdecilla, E-39005 Santander, Spain.
[Wenstrup, Richard J.; Kaldate, Rajesh R.] Myriad Genet Labs, Salt Lake City, UT USA.
[Krebs, Marie Odile; Mam-Lam-Fook, Celia; Bourgin, Julie] Serv Hosp Univ, Hopt St Anne, Ctr Evaluat Jeunes Adultes & Adolescents CJAAD, Fac Med Paris Descartes, Paris, France.
[Rothermundt, Matthias] Evangel Klinikum Niederrhein, Oberhausen, Germany.
NR 0
TC 0
Z9 0
U1 0
U2 4
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0586-7614
EI 1745-1701
J9 SCHIZOPHRENIA BULL
JI Schizophr. Bull.
PD MAR
PY 2015
VL 41
SU 1
MA 2085255
BP S13
EP S13
PG 1
WC Psychiatry
SC Psychiatry
GA CG8HO
UT WOS:000353548200034
ER
PT J
AU Sethi, J
Palit, R
Carroll, JJ
Karamian, S
Saha, S
Biswas, S
Naik, Z
Trivedi, T
Litz, MS
Datta, P
Chattopadhyay, S
Donthi, R
Garg, U
Jadhav, S
Jain, HC
Kumar, S
Mehta, D
Naidu, BS
Bhat, GH
Sheikh, JA
Sihotra, S
Walker, PM
AF Sethi, J.
Palit, R.
Carroll, J. J.
Karamian, S.
Saha, S.
Biswas, S.
Naik, Z.
Trivedi, T.
Litz, M. S.
Datta, P.
Chattopadhyay, S.
Donthi, R.
Garg, U.
Jadhav, S.
Jain, H. C.
Kumar, S.
Mehta, D.
Naidu, B. S.
Bhat, G. H.
Sheikh, J. A.
Sihotra, S.
Walker, P. M.
TI SPECTROSCOPY OF THE LOW-LYING STATES NEAR THE HIGH SPIN ISOMER IN Ag-108
SO ACTA PHYSICA POLONICA B
LA English
DT Article; Proceedings Paper
CT Zakopane Conference on Nuclear Physics - Extremes of the Nuclear
Landscape
CY AUG 31-SEP 07, 2014
CL Zakopane, POLAND
AB A comprehensive study of the low-lying states of Ag-108, near the isomeric state at E-i = 110 keV with J(pi) = 6(+) and T-1/2 = 438 y, has been presented. Spectroscopy of these states has been carried out using the reaction Mo-100(B-11, 3n gamma)Ag-108 at 39 MeV beam energy using INGA. The multipolarities and electromagnetic nature of the transitions have been assigned based on the angular correlation and polarization measurements. The experimentally identified states have been compared to the results of the Projected Hartree-Fock calculations to understand the configurations involved in these states.
C1 [Sethi, J.; Palit, R.; Saha, S.; Biswas, S.; Trivedi, T.; Donthi, R.; Jadhav, S.; Jain, H. C.; Naidu, B. S.] Tata Inst Fundamental Res, Bombay 400005, Maharashtra, India.
[Carroll, J. J.; Litz, M. S.] US Army Res Lab, Adelphi, MD 20783 USA.
[Karamian, S.] Joint Inst Nucl Res, Dubna 141980, Russia.
[Naik, Z.] Sambalpur Univ, Sambalpur 768019, India.
[Datta, P.] Ananda Mohan Coll, Kolkata 700009, India.
[Chattopadhyay, S.] Saha Inst Nucl Phys, Kolkata 700064, India.
[Garg, U.] Univ Notre Dame, Notre Dame, IN 46556 USA.
[Kumar, S.] Univ Delhi, Delhi 110007, India.
[Mehta, D.; Sihotra, S.] Panjab Univ, Chandigarh 160014, India.
[Bhat, G. H.; Sheikh, J. A.] Univ Kashmir, Dept Phys, Srinagar 190006, Jammu & Kashmir, India.
[Walker, P. M.] Univ Surrey, Dept Phys, Guildford GU2 7XH, Surrey, England.
RP Sethi, J (reprint author), Tata Inst Fundamental Res, Homi Bhabha Rd, Bombay 400005, Maharashtra, India.
RI Palit, Rudrajyoti/F-5185-2012
FU Department of Science and Technology, Government of India
[IR/S2/PF-03/2003-II]
FX The authors would like to thank the members of INGA PICC and INGA
Collaboration and the accelerator staff at TIFR-BARC Pelletron-LINAC
Facility. This work was partially supported by the Department of Science
and Technology, Government of India (Grant No. IR/S2/PF-03/2003-II).
NR 10
TC 1
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U1 0
U2 1
PU WYDAWNICTWO UNIWERSYTETU JAGIELLONSKIEGO
PI KRAKOW
PA UL GRODZKA 26, KRAKOW, 31044, POLAND
SN 0587-4254
EI 1509-5770
J9 ACTA PHYS POL B
JI Acta Phys. Pol. B
PD MAR
PY 2015
VL 46
IS 3
BP 703
EP 707
DI 10.5506/APhysPolB.46.703
PG 5
WC Physics, Multidisciplinary
SC Physics
GA CG8NR
UT WOS:000353565500054
ER
PT J
AU Terrill, WA
AF Terrill, W. Andrew
TI Iran's Strategy for Saving Asad
SO MIDDLE EAST JOURNAL
LA English
DT Article
AB For decades, Iran has supported the regime of Bashar al-Asad in Syria with military advisors, weapons, and both diplomatic and financial support due to Tehran's belief that a pro-Iranian government in Syria is a core national interest. In this regard, cooperation with Damascus has provided Tehran with a number of strategic advantages, which it is loath to surrender. More recently, the Iranians have also come to view Syria as a vital ally against the threat of the Islamic State in Iraq and al-Sham (ISIS). In this environment, the Islamic Republic will likely continue to bolster the Asad regime even if the Syrian civil war continues for years.
C1 US Army War Coll, Strateg Studies Inst, Carlisle, PA 17013 USA.
RP Terrill, WA (reprint author), US Army War Coll, Strateg Studies Inst, Carlisle, PA 17013 USA.
NR 81
TC 0
Z9 0
U1 6
U2 16
PU MIDDLE EAST INST
PI WASHINGTON
PA 1761 N ST NW, CIRCULATION DEPT, WASHINGTON, DC 20036-2882 USA
SN 0026-3141
EI 1940-3461
J9 MIDDLE EAST J
JI Middle East J.
PD SPR
PY 2015
VL 69
IS 2
BP 222
EP 236
DI 10.3751/69.2.13
PG 15
WC Area Studies
SC Area Studies
GA CH1PY
UT WOS:000353795000004
ER
PT J
AU Haight, DJ
Esposito, ER
Wilken, JM
AF Haight, Derek J.
Esposito, Elizabeth Russell
Wilken, Jason M.
TI Biomechanics of uphill walking using custom ankle-foot orthoses of three
different stiffnesses
SO GAIT & POSTURE
LA English
DT Article
DE Incline; IDEO; Ankle brace; Gait; Limb salvage; Military
ID ENERGY-COST; SLOPED SURFACES; STROKE SUBJECTS; GAIT; LOCOMOTION;
REHABILITATION; INDIVIDUALS; PERFORMANCE; KINEMATICS; PARAMETERS
AB Ankle-foot orthoses (AFOs) can provide support and improve walking ability in individuals with plantarflexor weakness. Passive-dynamic AFO stiffness can be optimized for over-ground walking, however little research exists for uphill walking, when plantarflexor contributions are key. Purpose: Compare uphill walking biomechanics (1) between dynamic AFO users and able-bodied control subjects. (2) between injured and sound limbs (3) across different AFO stiffnesses. Methods: Twelve patients with unilateral limb-salvage and twelve matched, able-bodied controls underwent biomechanical gait analysis when walking up a 10 degrees incline. Three AFO stiffnesses were tested in the patient group: Nominal (clinically prescribed), Compliant (20% less stiff), and Stiff (20% more stiff). Results and discussion: AFO users experienced less ankle motion and power generation, lower knee extensor moments, and greater hip flexion and power generation than controls during uphill walking. Despite these deviations, they walked at equivalent self-selected velocities and stride lengths. Asymmetries were present at the ankle and knee with decreased ankle motion and power, and lower knee extensor moments on the AFO limb. Stiffer AFOs increased knee joint flexion but a 40% range in AFO stiffness had few other effects on gait. Therefore, a wide range of clinically prescribed AFO stiffnesses may adequately assist uphill walking. Published by Elsevier B.V.
C1 [Haight, Derek J.; Esposito, Elizabeth Russell; Wilken, Jason M.] Brooke Army Med Ctr, Dept Orthopaed & Rehabil, Ctr Intrepid, Ft Sam Houston, TX 78234 USA.
RP Esposito, ER (reprint author), Brooke Army Med Ctr, Dept Orthopaed & Rehabil, Ctr Intrepid, Ft Sam Houston, TX 78234 USA.
EM erussell.kin@gmail.com
OI Wilken, Jason/0000-0002-5556-7667
FU Center for Rehabilitation Sciences Research Department of Physical
Medicine and Rehabilitation, Uniformed Services University of Health
Sciences, Bethesda, MD
FX The authors acknowledge Nicole Harper and Dr. Richard Neptune at the
University of Texas for strut manufacturing and testing. Support was
provided by the Center for Rehabilitation Sciences Research Department
of Physical Medicine and Rehabilitation, Uniformed Services University
of Health Sciences, Bethesda, MD.
NR 29
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Z9 4
U1 2
U2 13
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
IRELAND
SN 0966-6362
EI 1879-2219
J9 GAIT POSTURE
JI Gait Posture
PD MAR
PY 2015
VL 41
IS 3
BP 750
EP 756
DI 10.1016/j.gaitpost.2015.01.001
PG 7
WC Neurosciences; Orthopedics; Sport Sciences
SC Neurosciences & Neurology; Orthopedics; Sport Sciences
GA CG3WB
UT WOS:000353209200002
PM 25743775
ER
PT J
AU Platteborze, P
Matos, R
Gidvany-Diaz, V
Wilhelms, K
AF Platteborze, Peter
Matos, Renee
Gidvany-Diaz, Vinod
Wilhelms, Kelly
TI An Unexpected Emergency Request for Glucose-6-Phosphate Dehydrogenase
Testing in a 9-Year-Old African American Boy
SO LABMEDICINE
LA English
DT Article
DE deficiency; glucose-6-phosphate dehydrogenase; leukemia; rasburicase;
tumor lysis syndrome; uric acid
ID TUMOR LYSIS SYNDROME; METHEMOGLOBINEMIA; RASBURICASE; DEFICIENCY;
MANAGEMENT
AB Patient: 9-year-old African American male.
Chief Complaint: Recently diagnosed with acute lymphoblastic leukemia (ALL) after investigation into a large anterior mediastinal mass causing airway compression.
History of Present Illness: The day before the unexpected urgent glucose-6-phosphate dehydrogenase (136PD) request, the patient was diagnosed with an aggressive form of leukemia and a significant tumor mass causing airway compression. A computed tomography (CT) scan indicated potential renal involvement. Based on this information and the size of the mass, the patient was referred for immediate chemotherapy. However, there was a concern that he could develop tumor lysis syndrome (TLS) during treatment. To avoid this condition, the pediatric intensive care unit (ICU) sought to pretreat the child with rasburicase, which led to the emergency G6PD request.
Previous Medical History: Unknown.
Family History: Largely unknown, but no apparent chronic diseases.
Physical Examination Findings: Three weeks of progressively worsening lymphadenopathy, coughing, night sweats, mild hepatosplenomegaly, and breathing difficulty when supine. The patient arrived at the medical center for airway management and had a temperature of 36.1 degrees C; blood pressure, 120/87 mmHg; pulse, 115 bpm; respiratory rate, 22 breaths per minute, with labored breathing but normal O-2 saturation while upright and awake, in room air.
Principle Laboratory Findings: Table 1.
C1 [Platteborze, Peter; Wilhelms, Kelly] Brooke Army Med Ctr, Dept Pathol & Area Lab Serv, San Antonio, TX 78234 USA.
[Matos, Renee; Gidvany-Diaz, Vinod] Brooke Army Med Ctr, Dept Pediat, San Antonio, TX USA.
RP Platteborze, P (reprint author), Brooke Army Med Ctr, Dept Pathol & Area Lab Serv, San Antonio, TX 78234 USA.
NR 10
TC 0
Z9 0
U1 1
U2 3
PU AMER SOC CLINICAL PATHOLOGY
PI CHICAGO
PA 2100 W HARRISON ST, CHICAGO, IL 60612 USA
SN 0007-5027
EI 1943-7730
J9 LABMEDICINE
JI Labmedicine
PD SPR
PY 2015
VL 46
IS 2
BP 150
EP 152
DI 10.1309/LMEEC680QNEHOGIF
PG 3
WC Medical Laboratory Technology
SC Medical Laboratory Technology
GA CG3MR
UT WOS:000353184800010
PM 25918195
ER
PT J
AU Lyke, J
Christodoulou, CG
Vera, A
Edwards, AH
AF Lyke, James
Christodoulou, Christos G.
Vera, Alonzo
Edwards, Art H.
TI Special Issue on Reconfigurable Systems: Foundations
SO PROCEEDINGS OF THE IEEE
LA English
DT Editorial Material
C1 [Lyke, James] US Air Force, Washington, DC USA.
[Lyke, James] AFRL, Space Vehicles Directorate AFRL RV, Kirtland AFB, NM USA.
[Lyke, James] AIAA, Washington, DC USA.
[Lyke, James] AIAA Comp Syst Tech Comm, Washington, DC USA.
[Christodoulou, Christos G.] Univ New Mexico, Dept Elect & Comp Engn, Albuquerque, NM 87131 USA.
[Christodoulou, Christos G.] Univ New Mexico, Albuquerque, NM 87131 USA.
[Christodoulou, Christos G.] Univ New Mexico, COSMIAC Configurable Space Microsyst Innovat & Ap, Albuquerque, NM 87131 USA.
[Edwards, Art H.] Air Force Res Lab, Space Vehicles Directorate, Wright Patterson AFB, OH USA.
[Edwards, Art H.] Westinghouse Elect, Cranberry Township, PA USA.
[Edwards, Art H.] Univ N Carolina, Charlotte, NC 28223 USA.
[Edwards, Art H.] Army Res Lab, Adelphi, MD USA.
[Edwards, Art H.] Air Force Res Lab, Wright Patterson AFB, OH USA.
RP Lyke, J (reprint author), AFRL Space Elect Branch, Space Vehicles Directorate, Wright Patterson AFB, OH 45433 USA.
NR 0
TC 0
Z9 0
U1 1
U2 5
PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
PI PISCATAWAY
PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA
SN 0018-9219
EI 1558-2256
J9 P IEEE
JI Proc. IEEE
PD MAR
PY 2015
VL 103
IS 3
SI SI
BP 287
EP 290
DI 10.1109/JPROC.2015.2399071
PG 4
WC Engineering, Electrical & Electronic
SC Engineering
GA CG2QH
UT WOS:000353119000002
ER
PT J
AU Lai, WC
Ogden, FL
Steinke, RC
Talbot, CA
AF Lai, Wencong
Ogden, Fred L.
Steinke, Robert C.
Talbot, Cary A.
TI An efficient and guaranteed stable numerical method for continuous
modeling of infiltration and redistribution with a shallow dynamic water
table
SO WATER RESOURCES RESEARCH
LA English
DT Article
DE infiltration and redistribution; vadose zone modeling; stable and mass
conservative
ID GREEN-AMPT INFILTRATION; RICHARDS EQUATION; POROUS-MEDIA; SOIL-WATER;
FLOW
AB We have developed a one-dimensional numerical method to simulate infiltration and redistribution in the presence of a shallow dynamic water table. This method builds upon the Green-Ampt infiltration with Redistribution (GAR) model and incorporates features from the Talbot-Ogden (T-O) infiltration and redistribution method in a discretized moisture content domain. The redistribution scheme is more physically meaningful than the capillary weighted redistribution scheme in the T-O method. Groundwater dynamics are considered in this new method instead of hydrostatic groundwater front. It is also computationally more efficient than the T-O method. Motion of water in the vadose zone due to infiltration, redistribution, and interactions with capillary groundwater are described by ordinary differential equations. Numerical solutions to these equations are computationally less expensive than solutions of the highly nonlinear Richards' (1931) partial differential equation. We present results from numerical tests on 11 soil types using multiple rain pulses with different boundary conditions, with and without a shallow water table and compare against the numerical solution of Richards' equation (RE). Results from the new method are in satisfactory agreement with RE solutions in term of ponding time, deponding time, infiltration rate, and cumulative infiltrated depth. The new method, which we call GARTO can be used as an alternative to the RE for 1-D coupled surface and groundwater models in general situations with homogeneous soils with dynamic water table. The GARTO method represents a significant advance in simulating groundwater surface water interactions because it very closely matches the RE solution while being computationally efficient, with guaranteed mass conservation, and no stability limitations that can affect RE solvers in the case of a near-surface water table.
C1 [Lai, Wencong; Ogden, Fred L.; Steinke, Robert C.] Univ Wyoming, Dept Civil & Architectural Engn, Laramie, WY 82071 USA.
[Talbot, Cary A.] US Army Corps Engineers Engineer Res & Dev Ctr, Coastal & Hydraul Lab, Vicksburg, MS USA.
RP Lai, WC (reprint author), Univ Wyoming, Dept Civil & Architectural Engn, Laramie, WY 82071 USA.
EM wlai@uwyo.edu
FU US National Science Foundation, EPSCoR program [EPS-1135483]; CI-WATER
project
FX This research was funded by the US National Science Foundation, EPSCoR
program, through cooperative agreement EPS-1135483 to the University of
Wyoming and the CI-WATER project. Simulation data and results are
available from the authors upon request. The authors thank three
anonymous reviewers and two editors for their helpful comments and
suggestions.
NR 26
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Z9 3
U1 2
U2 17
PU AMER GEOPHYSICAL UNION
PI WASHINGTON
PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA
SN 0043-1397
EI 1944-7973
J9 WATER RESOUR RES
JI Water Resour. Res.
PD MAR
PY 2015
VL 51
IS 3
BP 1514
EP 1528
DI 10.1002/2014WR016487
PG 15
WC Environmental Sciences; Limnology; Water Resources
SC Environmental Sciences & Ecology; Marine & Freshwater Biology; Water
Resources
GA CG3DU
UT WOS:000353158800008
ER
PT J
AU McCoy, JR
Mendoza, JM
Spik, KW
Badger, C
Gomez, AF
Schmaljohn, CS
Sardesai, NY
Broderick, KE
AF McCoy, Jay R.
Mendoza, Janess M.
Spik, Kristin W.
Badger, Catherine
Gomez, Alan F.
Schmaljohn, Connie S.
Sardesai, Niranjan Y.
Broderick, Kate E.
TI A multi-head intradermal electroporation device allows for tailored and
increased dose DNA vaccine delivery to the skin
SO HUMAN VACCINES & IMMUNOTHERAPEUTICS
LA English
DT Article
DE dermal; DNA vaccine; electroporation; multi-agent; noninvasive;
tolerable
ID IN-VIVO ELECTROPORATION; IMMUNE-RESPONSES; NEUTRALIZING ANTIBODY;
NONHUMAN-PRIMATES; CODON USAGE; VIRUS; IMMUNOGENICITY; CHALLENGE; MODEL;
IMMUNIZATION
AB The identification of an effective and tolerable delivery method is a necessity for the success of DNA vaccines in the clinic. This article describes the development and validation of a multi-headed intradermal electroporation device which would be applicable for delivering multiple DNA vaccine plasmids simultaneously but spatially separated. Reporter gene plasmids expressing green and red fluorescent proteins were used to demonstrate the impact of spatial separation on DNA delivery to increase the number of transfected cells and avoid interference through visible expression patterns. To investigate the impact of plasmid interference on immunogenicity, a disease target was investigated where issues with multi-valent vaccines had been previously described. DNA-based Hantaan and Puumala virus vaccines were delivered separately or as a combination and the effect of multi-valence was determined by appropriate assays. While a negative impact was observed for both antigenic vaccines when delivered together, these effects were mitigated when the vaccine was delivered using the multi-head device. We also demonstrate how the multi-head device facilitates higher dose delivery to the skin resulting in improved immune responses. This new multi-head platform device is an efficient, tolerable and non-invasive method to deliver multiple plasmid DNA constructs simultaneously allowing the tailoring of delivery sites for combination vaccines. Additionally, this device would allow the delivery of multi-plasmid vaccine formulations without risk of impacted immune responses through interference. Such a low-cost, easy to use device platform for the delivery of multi-agent DNA vaccines would have direct applications by the military and healthcare sectors for mass vaccination purposes.
C1 [McCoy, Jay R.; Mendoza, Janess M.; Gomez, Alan F.; Sardesai, Niranjan Y.; Broderick, Kate E.] Inovio Pharmaceut Inc, Blue Bell, PA 19462 USA.
[Spik, Kristin W.; Badger, Catherine; Schmaljohn, Connie S.] US Army Med Res Inst Infect Dis, Ft Detrick, MD USA.
RP Broderick, KE (reprint author), Inovio Pharmaceut Inc, Blue Bell, PA 19462 USA.
EM kbroderick@inovio.com
RI bebarta, vikhyat/K-3476-2015
FU Department of Defense SBIR [W81XWH-11-C-0051]
FX This work was supported in part by a Department of Defense SBIR grant
(Phase I and Phase II) number W81XWH-11-C-0051.
NR 41
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Z9 0
U1 2
U2 4
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 2164-5515
EI 2164-554X
J9 HUM VACC IMMUNOTHER
JI Human Vaccines Immunother.
PD MAR
PY 2015
VL 11
IS 3
BP 746
EP 754
DI 10.4161/21645515.2014.978223
PG 9
WC Biotechnology & Applied Microbiology; Immunology
SC Biotechnology & Applied Microbiology; Immunology
GA CF5SA
UT WOS:000352616100037
PM 25839221
ER
PT J
AU Balaban, E
Saxena, A
Narasimhan, S
Roychoudhury, I
Koopmans, M
Ott, C
Goebel, K
AF Balaban, Edward
Saxena, Abhinav
Narasimhan, Sriram
Roychoudhury, Indranil
Koopmans, Michael
Ott, Carl
Goebel, Kai
TI Prognostic Health-Management System Development for Electromechanical
Actuators
SO JOURNAL OF AEROSPACE INFORMATION SYSTEMS
LA English
DT Article
ID FLIGHT
AB Electromechanical actuators have been gaining increased acceptance as safety-critical actuation devices in the next generation of aircraft and spacecraft. The aerospace manufacturers are not ready, however, to completely embrace electromechanical actuators for all applications due to apprehension with regard to some of the more critical fault modes. This work aims to help address these concerns by developing and testing a prognostic health-management system that diagnoses electromechanical actuator faults and employs prognostic algorithms to track fault progression and predict the actuator's remaining useful life. The diagnostic algorithm is implemented using a combined model-based and data-driven reasoner. The prognostic algorithm, implemented using Gaussian process regression, estimates the remaining life of the faulted component. The paper also covers the selection of fault modes for coverage and methods developed for fault injection. Validation experiments were conducted in both laboratory and flight conditions using a flyable electromechanical actuator test stand. The stand allows test actuators to be subjected to realistic environmental and operating conditions while providing the capability to safely inject and monitor propagation of various fault modes. The paper covers both diagnostic and prognostic run-to-failure experiments, conducted in laboratory and flight conditions for several types of faults. The experiments demonstrated robust fault diagnosis on the selected set of component and sensor faults and high-accuracy predictions of failure time in prognostic scenarios.
C1 [Balaban, Edward; Goebel, Kai] NASA, Ames Res Ctr, Intelligent Syst Div, Discovery & Syst Hlth Area, Moffett Field, CA 94035 USA.
[Saxena, Abhinav; Roychoudhury, Indranil] NASA, Ames Res Ctr, SGT Inc, Intelligent Syst Div,Discovery & Syst Hlth Area, Moffett Field, CA 94035 USA.
[Narasimhan, Sriram] Univ Calif Santa Cruz, NASA, Ames Res Ctr, Intelligent Syst Div,Discovery & Syst Hlth Area, Moffett Field, CA 94035 USA.
[Ott, Carl] Tesla Motors, Palo Alto, CA 94035 USA.
[Ott, Carl] NASA, Ames Res Ctr, US Army, Aviat Dev Directorate, Moffett Field, CA 94035 USA.
RP Balaban, E (reprint author), NASA, Ames Res Ctr, Intelligent Syst Div, Discovery & Syst Hlth Area, MS 269-4, Moffett Field, CA 94035 USA.
EM edward.balaban@nasa.gov; abhinav.saxena@nasa.gov;
sriram.narasimhan@nasa.gov; indranil.roychoudhury@nasa.gov;
michael.t.koopmans@gmail.com; carl.r.ott.mil@mail.mil;
kai.goebel@nasa.gov
FU NASA
FX The funding for this work was provided by the NASA Aviation Safety
Program, Integrated Vehicle Health Management and Systemwide Safety
Assurance Technologies projects. We would like to thank our colleagues
at NASA Ames Research Center for both their help with this research and
in preparation of the manuscript. A special thanks goes to Catlin
Mattheis and Austin Lawrence, who helped to create the original Flyable
electromechanical actuator (FLEA) testbed prototype while at California
Polytechnic State University. Steven Braddom, formerly of the U.S. Army
Aeroflightdynamics (AFFD) Directorate Flight Projects Office, provided
steadfast support for the initial UH-60 flight tests. The flight tests
would also not have been possible without the support of AFFD engineers,
technicians, and pilots (Casey Blaskowski, Gary Leong, Gary Fayaud,
Ellazar Barrientos, Richard Huber, Jay Fletcher, Juan Saucedo, Scott
Miller, Ernie Moralez, Munro Dearing, Randall Watson, and Samuel
Caires). We also express our gratitude to Steven Fletcher, Bruce Felt,
Pete Chaplin, Phillip Jensen, and Minh Wong for their assistance in
fabricating the various components of the FLEA.
NR 38
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Z9 7
U1 2
U2 17
PU AMER INST AERONAUTICS ASTRONAUTICS
PI RESTON
PA 1801 ALEXANDER BELL DRIVE, STE 500, RESTON, VA 22091-4344 USA
SN 1940-3151
EI 2327-3097
J9 J AEROSP INFORM SYST
JI J. Aerosp. Inf. Syst.
PD MAR
PY 2015
VL 12
IS 3
BP 329
EP 344
DI 10.2514/1.I010171
PG 16
WC Engineering, Aerospace
SC Engineering
GA CF8DH
UT WOS:000352785300003
ER
PT J
AU Hermann, LL
Gupta, SB
Manoff, SB
Kalayanarooj, S
Gibbons, RV
Coller, BAG
AF Hermann, Laura L.
Gupta, Swati B.
Manoff, Susan B.
Kalayanarooj, Siripen
Gibbons, Robert V.
Coller, Beth-Ann G.
TI Advances in the understanding, management, and prevention of dengue
SO JOURNAL OF CLINICAL VIROLOGY
LA English
DT Article
DE Dengue; Treatment; Diagnosis; Vaccine; Epidemiology
ID HEALTHY ADULT VOLUNTEERS; PLACEBO-CONTROLLED TRIAL; ANTIBODY-DEPENDENT
ENHANCEMENT; CROSS-REACTIVE ANTIBODIES; TYPE-4 VACCINE CANDIDATE;
BLOOD-FEEDING SUCCESS; ENVELOPE DOMAIN III; T-CELL RESPONSES;
VIRUS-INFECTION; AEDES-AEGYPTI
AB Dengue causes more human morbidity globally than any other vector-borne viral disease. Recent research has led to improved epidemiological methods that predict disease burden and factors involved in transmission, a better understanding of immune responses in infection, and enhanced animal models. In addition, a number of control measures, including preventative vaccines, are in clinical trials. However, significant gaps remain, including the need for better surveillance in large parts of the world, methods to predict which individuals will develop severe disease, and immunologic correlates of protection against dengue illness. During the next decade, dengue will likely expand its geographic reach and become an increasing burden on health resources in affected areas. Licensed vaccines and antiviral agents are needed in order to effectively control dengue and limit disease. (C) 2014 Elsevier B.V. All rights reserved.
C1 [Hermann, Laura L.] Univ Toronto, Dept Med, Toronto, ON, Canada.
[Hermann, Laura L.; Gibbons, Robert V.] Armed Forces Res Inst Med Sci, Dept Virol, Bangkok 10400, Thailand.
[Gupta, Swati B.; Manoff, Susan B.; Coller, Beth-Ann G.] Merck & Co Inc, N Wales, PA 19454 USA.
[Kalayanarooj, Siripen] Queen Sirikit Natl Inst Child Hlth, Bangkok, Thailand.
RP Coller, BAG (reprint author), Merck & Co Inc, 351 North Sumneytown Pike, N Wales, PA 19454 USA.
EM beth-ann.coller@merck.com
FU Canadian Institutes of Health Research Fellowship
FX Laura Hermann was supported by a Canadian Institutes of Health Research
Fellowship. Swati Gupta, Susan Manoff, and Beth-Ann Coller are the
Employees of Merck Research Laboratories.
NR 138
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U1 0
U2 13
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1386-6532
EI 1873-5967
J9 J CLIN VIROL
JI J. Clin. Virol.
PD MAR
PY 2015
VL 64
BP 153
EP 159
DI 10.1016/j.jcv.2014.08.031
PG 7
WC Virology
SC Virology
GA CF0ZP
UT WOS:000352273600026
PM 25453329
ER
PT J
AU Arnold, F
DeMallie, I
Florence, L
Kashinski, DO
AF Arnold, F.
DeMallie, I.
Florence, L.
Kashinski, D. O.
TI Method for collecting thermocouple data via secured shell over a
wireless local area network in real time
SO REVIEW OF SCIENTIFIC INSTRUMENTS
LA English
DT Article
AB This manuscript addresses the design, hardware details, construction, and programming of an apparatus allowing an experimenter to monitor and record high-temperature thermocouple measurements of dynamic systems in real time. The apparatus uses wireless network technology to bridge the gap between a dynamic (moving) sample frame and the static laboratory frame. Our design is a custom solution applied to samples that rotate through large angular displacements where hard-wired and typical slip-ring solutions are not practical because of noise considerations. The apparatus consists of a Raspberry PI mini-Linux computer, an Arduino micro-controller, an Ocean Controls thermocouple multiplexer shield, and k-type thermocouples.
C1 [Arnold, F.; DeMallie, I.; Florence, L.; Kashinski, D. O.] US Mil Acad, Photon Res Ctr, West Point, NY 10996 USA.
RP Arnold, F (reprint author), US Mil Acad, Photon Res Ctr, West Point, NY 10996 USA.
EM david.kashinski@usma.edu
FU USMA; Army Research Office [ARO 64793-PH]; High Energy Laser Joint
Technology Office [HEL-JTO 248-8212]
FX D.O.K., L.F., I.D., and F.A. acknowledge support from USMA. D.O.K. and
L.F. also acknowledge support from the Army Research Office Grant No.
ARO 64793-PH and the High Energy Laser Joint Technology Office Grant No.
HEL-JTO 248-8212.
NR 10
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U1 1
U2 17
PU AMER INST PHYSICS
PI MELVILLE
PA 1305 WALT WHITMAN RD, STE 300, MELVILLE, NY 11747-4501 USA
SN 0034-6748
EI 1089-7623
J9 REV SCI INSTRUM
JI Rev. Sci. Instrum.
PD MAR
PY 2015
VL 86
IS 3
AR 035112
DI 10.1063/1.4915490
PG 5
WC Instruments & Instrumentation; Physics, Applied
SC Instruments & Instrumentation; Physics
GA CE9ZD
UT WOS:000352201400077
PM 25832280
ER
PT J
AU Stewart, JB
Pecora, C
AF Stewart, Joel B.
Pecora, Collin
TI Explosively driven air blast in a conical shock tube
SO REVIEW OF SCIENTIFIC INSTRUMENTS
LA English
DT Article
AB Explosively driven shock tubes present challenges in terms of safety concerns and expensive upkeep of test facilities but provide more realistic approximations to the air blast resulting from free-field detonations than those provided by gas-driven shock tubes. Likewise, the geometry of conical shock tubes can naturally approximate a sector cut from a spherically symmetric blast, leading to a better agreement with the blast profiles of free-field detonations when compared to those provided by shock tubes employing constant cross sections. The work presented in this article documents the design, fabrication, and testing of an explosively driven conical shock tube whose goal was to closely replicate the blast profile seen from a larger, free-field detonation. By constraining the blast through a finite area, large blasts (which can add significant damage and safety constraints) can be simulated using smaller explosive charges. The experimental data presented herein show that a close approximation to the free-field air blast profile due to a 1.5 lb charge of C4 at 76 in. can be achieved by using a 0.032 lb charge in a 76-in.-long conical shock tube (which translates to an amplification factor of nearly 50). Modeling and simulation tools were used extensively in designing this shock tube to minimize expensive fabrication costs.
C1 [Stewart, Joel B.; Pecora, Collin] US Army, Res Lab, Aberdeen Proving Ground, MD 21005 USA.
RP Stewart, JB (reprint author), US Army, Res Lab, Aberdeen Proving Ground, MD 21005 USA.
EM joel.b.stewart2.civ@mail.mil; collin.r.pecora.civ@mail.mil
OI Stewart, Joel/0000-0002-3059-4917
FU ARL's Survivability and Lethality Analysis Directorate
FX Ms. Rachel Ehlers initiated our investigation into explosively driven
shock tubes and the authors would like to acknowledge her direction and
enthusiasm throughout this program. Dr. Barrie Homan and Dr. Scott
Kukuck were solicited for numerous technical discussions throughout the
program's planning and execution and their input is greatly appreciated.
Dr. Homan also operated the class 4 copper vapor laser, which was used
to illuminate some of the experiments detailed in this article. Dr. Andy
Anderson and Dr. Ed Kokko of LLNL and Dr. Richard Becker of ARL provided
helpful advice concerning the ALE3D calculations. The authors would like
to acknowledge Mr. Eric Wilson, the test director for the shock tube
experimental program, for his attention to detail and ensuring that the
experimental series ran smoothly. Mr. Jason Pierce and Mr. Jason Garvey
were instrumental in setting up the diagnostic equipment in the
experiments and collecting the data accurately and efficiently. The
authors are also grateful to the ARL shops (particularly, Mr. Bobby
Hall, Mr. David Weyand, and Mr. Dennis Hash) for fabricating the shock
tube and stand, along with the explosive centering devices. Finally, the
authors would like to acknowledge Mr. Pat Gillich of ARL's Survivability
and Lethality Analysis Directorate for providing overall guidance and
financial support and for identifying the critical need to evaluate the
blast effects on personnel protective equipment in a controlled manner.
NR 9
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U1 0
U2 5
PU AMER INST PHYSICS
PI MELVILLE
PA 1305 WALT WHITMAN RD, STE 300, MELVILLE, NY 11747-4501 USA
SN 0034-6748
EI 1089-7623
J9 REV SCI INSTRUM
JI Rev. Sci. Instrum.
PD MAR
PY 2015
VL 86
IS 3
AR 035108
DI 10.1063/1.4914898
PG 9
WC Instruments & Instrumentation; Physics, Applied
SC Instruments & Instrumentation; Physics
GA CE9ZD
UT WOS:000352201400073
PM 25832276
ER
PT J
AU Jiang, HQ
Radtke, PJ
Weiskittel, AR
Coulston, JW
Guertin, PJ
AF Jiang, Huiquan
Radtke, Philip J.
Weiskittel, Aaron R.
Coulston, John W.
Guertin, Patrick J.
TI Climate- and soil-based models of site productivity in eastern US tree
species
SO CANADIAN JOURNAL OF FOREST RESEARCH
LA English
DT Article
DE bootstrap; climate change; climate envelope models; random forest;
regression trees; site index
ID WESTERN UNITED-STATES; FOREST INVENTORY; INDEX; PINE; PREDICTION;
VARIABLES; REGRESSION; SPRUCE; PLANTATIONS; STANDS
AB As concerns rise over potential effects of greenhouse gas related climate change on terrestrial ecosystems, forest managers require growth and yield modeling capabilities responsive to changing climate conditions. Our goal was to develop prediction models of site index for eastern US forest tree species with climate and soil properties as predictors for use in predicting potential responses of forest productivity to climate change. Species-specific site index data from the USDA Forest Service Forest Inventory and Analysis (FIA) program were linked to contemporary climate data and soil properties mapped in the USDA Soil Survey Geographic (SSURGO) database. Random forest regression tree based ensemble prediction models of site index were constructed based on 37 climate-related and 15 soil attributes. In addition to a species-specific site index, aggregate models were developed for species grouped into two broad categories: conifer (softwood) and hardwood (broadleaved) species groups. Species-specific models based on climate and soil predictors explained the most variation in site index of any models tested (R-2 = 62.5%, RMSE = 3.2 m). Comparable results were found when grouping species into conifer and hardwood groups (R-2 = 63.9%, RMSE = 4.6 m for conifers; R-2 = 35.9%, RMSE = 4.2 m for hardwoods). Model predictions based on multiple global circulation models (GCMs) and Intergovernmental Panel on Climate Change (IPCC) development scenarios were tested for statistical significance using bootstrap resampling methods. Results showed significant increases over the 21st century in mean site index for conifers between +0.5 and +2.4 m. Over the same time period, mean hardwood site index showed decreases of as much as -1.7 m for the scenarios tested. The results demonstrate the utility of using climate and soils data in predicting site index across a large geographic region, and the potential of climate change to alter forest productivity in the eastern US. Additional investigation is needed to interpret spatial patterns and ecological relationships related to predictions from this type of model.
C1 [Jiang, Huiquan; Radtke, Philip J.] Virginia Tech, Forest Resources & Environm Conservat, Blacksburg, VA 24061 USA.
[Weiskittel, Aaron R.] Univ Maine, Sch Forest Resources, Orono, ME 04469 USA.
[Coulston, John W.] ARS, USDA, Knoxville, TN 37919 USA.
[Guertin, Patrick J.] US Army Engn Res & Dev Ctr, Construct Engn Res Lab, Champaign, IL 61826 USA.
RP Radtke, PJ (reprint author), Virginia Tech, Forest Resources & Environm Conservat, Blacksburg, VA 24061 USA.
EM pradtke@vt.edu
OI Radtke, Philip/0000-0002-8921-8406
FU U.S. Department of the Army; Southern Appalachian Mountains (SAM)
Cooperative Ecosystem Studies Unit (CESU)
FX This research was supported with funding from the U.S. Department of the
Army in cooperation with the Southern Appalachian Mountains (SAM)
Cooperative Ecosystem Studies Unit (CESU).
NR 74
TC 2
Z9 3
U1 4
U2 23
PU CANADIAN SCIENCE PUBLISHING, NRC RESEARCH PRESS
PI OTTAWA
PA 65 AURIGA DR, SUITE 203, OTTAWA, ON K2E 7W6, CANADA
SN 0045-5067
EI 1208-6037
J9 CAN J FOREST RES
JI Can. J. For. Res.
PD MAR
PY 2015
VL 45
IS 3
BP 325
EP 342
DI 10.1139/cjfr-2014-0054
PG 18
WC Forestry
SC Forestry
GA CF0CX
UT WOS:000352211400011
ER
PT J
AU Meyers, RE
Deacon, KS
AF Meyers, Ronald E.
Deacon, Keith S.
TI Space-Time Quantum Imaging
SO ENTROPY
LA English
DT Article
ID COHERENCE
AB We report on an experimental and theoretical investigation of quantum imaging where the images are stored in both space and time. Ghost images of remote objects are produced with either one or two beams of chaotic laser light generated by a rotating ground glass and two sensors measuring the reference field and bucket field at different space-time points. We further observe that the ghost images translate depending on the time delay between the sensor measurements. The ghost imaging experiments are performed both with and without turbulence. A discussion of the physics of the space-time imaging is presented in terms of quantum nonlocal two-photon analysis to support the experimental results. The theoretical model includes certain phase factors of the rotating ground glass. These experiments demonstrated a means to investigate the time and space aspects of ghost imaging and showed that ghost imaging contains more information per measured photon than was previously recognized where multiple ghost images are stored within the same ghost imaging data sets. This suggests new pathways to explore quantum information stored not only in multi-photon coincidence information but also in time delayed multi-photon interference. The research is applicable to making enhanced space-time quantum images and videos of moving objects where the images are stored in both space and time.
C1 [Meyers, Ronald E.; Deacon, Keith S.] US Army Res Lab, Adelphi, MD 20783 USA.
RP Meyers, RE (reprint author), US Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA.
EM ronald.e.meyers6.civ@mail.mil; keith.s.deacon.civ@mail.mil
FU U.S. Army Research Laboratory
FX R.E. Meyers and K.S. Deacon thank the U.S. Army Research Laboratory for
support. The authors would also like to thank A. Tunick, P. Hemmer, Y.
Shih and S. Karmakar for helpful discussions.
NR 38
TC 1
Z9 1
U1 4
U2 16
PU MDPI AG
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1099-4300
J9 ENTROPY-SWITZ
JI Entropy
PD MAR
PY 2015
VL 17
IS 3
BP 1508
EP 1534
DI 10.3390/e17031508
PG 27
WC Physics, Multidisciplinary
SC Physics
GA CF5QR
UT WOS:000352612500037
ER
PT J
AU Hampton, SE
Moore, MV
Ozersky, T
Stanley, EH
Polashenski, CM
Galloway, AWE
AF Hampton, Stephanie E.
Moore, Marianne V.
Ozersky, Tedy
Stanley, Emily H.
Polashenski, Christopher M.
Galloway, Aaron W. E.
TI Heating up a cold subject: prospects for under-ice plankton research in
lakes
SO JOURNAL OF PLANKTON RESEARCH
LA English
DT Article
DE winter; ice; plankton; trophic interactions; nutritional quality; state
transitions
ID ARCTIC SEA-ICE; FRESH-WATER LAKES; CLIMATE-CHANGE;
AULACOSEIRA-BAICALENSIS; TROPHIC DYNAMICS; FATTY-ACIDS; SNOW COVER;
PEG-MODEL; BAIKAL; PHYTOPLANKTON
AB Long-term patterns and drivers of ecosystem structure may be misunderstood if knowledge of an ecosystem is derived primarily from a single season, a situation common in many temperate lakes where the role of winter has been less studied. In lakes, avoidance of winter research has been especially pronounced for those that experience winter ice, but critical ecological processes can take place under ice. Even when obscured by snow, ice transmitting as little as 2% incident light can allow relatively high rates of photosynthesis, and winter trophic interactions may have year-round repercussions. Here, we offer a suite of research questions that require attention, in order to build a mature understanding of seasonal plankton dynamics in lakes. Specifically, we ask freshwater ecologists to consider the extent to which abundance and nutrition of winter primary productivity supports consumers under the ice, reorganizes food webs, and how long the effects of winter trophic dynamics extend throughout the year. In addition, we recognize some critical gaps in knowledge about physical and biogeochemical conditions at the time of ice-off. Worldwide shortening in ice duration lends imperative to under-ice studies, in order to more fully understand changes in ecosystem structure and function that may already be underway.
C1 [Hampton, Stephanie E.; Galloway, Aaron W. E.] Washington State Univ, Ctr Environm Res Educ & Outreach, Pullman, WA 99164 USA.
[Moore, Marianne V.] Wellesley Coll, Dept Biol Sci, Wellesley, MA 02481 USA.
[Ozersky, Tedy] Univ Minnesota, Large Lakes Observ, Duluth, MN 55812 USA.
[Stanley, Emily H.] Univ Wisconsin, Dept Zool, Madison, WI 53706 USA.
[Stanley, Emily H.] Univ Wisconsin, Ctr Limnol, Madison, WI 53706 USA.
[Polashenski, Christopher M.] US Army, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA.
RP Hampton, SE (reprint author), Washington State Univ, Ctr Environm Res Educ & Outreach, Pullman, WA 99164 USA.
EM s.hampton@wsu.edu
OI Hampton, Stephanie/0000-0003-2389-4249
FU National Science Foundation (NSF DEB) [1431428, 1136637]; Washington
State University
FX Funding was provided by the National Science Foundation (NSF DEB
#1431428; NSF DEB #1136637) and Washington State University.
NR 66
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U1 4
U2 33
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0142-7873
EI 1464-3774
J9 J PLANKTON RES
JI J. Plankton Res.
PD MAR-APR
PY 2015
VL 37
IS 2
BP 277
EP 284
DI 10.1093/plankt/fbv002
PG 8
WC Marine & Freshwater Biology; Oceanography
SC Marine & Freshwater Biology; Oceanography
GA CF3ZK
UT WOS:000352487600001
ER
PT J
AU Memisevic, V
Zavaljevski, N
Rajagopala, SV
Kwon, K
Pieper, R
DeShazer, D
Reifman, J
Wallqvist, A
AF Memisevic, Vesna
Zavaljevski, Nela
Rajagopala, Seesandra V.
Kwon, Keehwan
Pieper, Rembert
DeShazer, David
Reifman, Jaques
Wallqvist, Anders
TI Mining Host-Pathogen Protein Interactions to Characterize Burkholderia
mallei Infectivity Mechanisms
SO PLOS COMPUTATIONAL BIOLOGY
LA English
DT Article
ID NETWORK ALIGNMENT; MOONLIGHTING PROTEINS; BACTERIAL VIRULENCE; GLOBAL
ALIGNMENT; IN-VIVO; PSEUDOMALLEI; SECRETION; STRATEGIES; BIOCONDUCTOR;
MELIOIDOSIS
AB Burkholderia pathogenicity relies on protein virulence factors to control and promote bacterial internalization, survival, and replication within eukaryotic host cells. We recently used yeast two-hybrid (Y2H) screening to identify a small set of novel Burkholderia proteins that were shown to attenuate disease progression in an aerosol infection animal model using the virulent Burkholderia mallei ATCC 23344 strain. Here, we performed an extended analysis of primarily nine B. mallei virulence factors and their interactions with human proteins to map out how the bacteria can influence and alter host processes and pathways. Specifically, we employed topological analyses to assess the connectivity patterns of targeted host proteins, identify modules of pathogen-interacting host proteins linked to processes promoting infectivity, and evaluate the effect of crosstalk among the identified host protein modules. Overall, our analysis showed that the targeted host proteins generally had a large number of interacting partners and interacted with other host proteins that were also targeted by B. mallei proteins. We also introduced a novel Host-Pathogen Interaction Alignment (HPIA) algorithm and used it to explore similarities between host-pathogen interactions of B. mallei, Yersinia pestis, and Salmonella enterica. We inferred putative roles of B. mallei proteins based on the roles of their aligned Y. pestis and S. enterica partners and showed that up to 73% of the predicted roles matched existing annotations. A key insight into Burkholderia pathogenicity derived from these analyses of Y2H host-pathogen interactions is the identification of eukaryotic-specific targeted cellular mechanisms, including the ubiquitination degradation system and the use of the focal adhesion pathway as a fulcrum for transmitting mechanical forces and regulatory signals. This provides the mechanisms to modulate and adapt the host-cell environment for the successful establishment of host infections and intracellular spread.
C1 [Memisevic, Vesna; Zavaljevski, Nela; Reifman, Jaques; Wallqvist, Anders] US Army Med Res & Mat Command, Dept Def, Biotechnol High Performance Comp Software Applica, Telemed & Adv Technol Res Ctr, Ft Detrick, MD 21702 USA.
[Rajagopala, Seesandra V.; Kwon, Keehwan; Pieper, Rembert] J Craig Venter Inst, Rockville, MD USA.
[DeShazer, David] US Army Med Res Inst Infect Dis, Bacteriol Div, Ft Detrick, MD USA.
RP Memisevic, V (reprint author), US Army Med Res & Mat Command, Dept Def, Biotechnol High Performance Comp Software Applica, Telemed & Adv Technol Res Ctr, Ft Detrick, MD 21702 USA.
EM jaques.reifman.civ@mail.mil
OI wallqvist, anders/0000-0002-9775-7469; Rajagopala,
Seesandra/0000-0001-7176-5770
FU U.S. Defense Threat Reduction Agency [CBS.MEDBIO.02.10.BH.021]; U.S.
Army Medical Research and Materiel Command as part of the U.S. Army's
Network Science Initiative
FX This work was supported by the U.S. Defense Threat Reduction
Agency(www.dtra.mil; award number CBS.MEDBIO.02.10.BH.021) and by the
U.S. Army Medical Research and Materiel Command (mrmc.amedd.army.mil) as
part of the U.S. Army's Network Science Initiative. The funders had no
role in study design, data collection and analysis, decision to publish,
or preparation of the manuscript.
NR 65
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Z9 5
U1 4
U2 12
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1553-734X
EI 1553-7358
J9 PLOS COMPUT BIOL
JI PLoS Comput. Biol.
PD MAR
PY 2015
VL 11
IS 3
AR UNSP e1004088
DI 10.1371/journal.pcbi.1004088
PG 28
WC Biochemical Research Methods; Mathematical & Computational Biology
SC Biochemistry & Molecular Biology; Mathematical & Computational Biology
GA CE9XB
UT WOS:000352195700014
PM 25738731
ER
PT J
AU Adler, AB
Williams, J
McGurk, D
Moss, A
Bliese, PD
AF Adler, Amy B.
Williams, Jason
McGurk, Dennis
Moss, Andrew
Bliese, Paul D.
TI Resilience Training with Soldiers during Basic Combat Training:
Randomisation by Platoon
SO APPLIED PSYCHOLOGY-HEALTH AND WELL BEING
LA English
DT Article
DE Basic Combat Training; group randomised trial; resilience
ID PSYCHOLOGICAL ADJUSTMENT; DEPRESSIVE SYMPTOMS; IRAQ RANDOMIZATION; NAVY
RECRUITS; INTERVENTIONS; PERCEPTIONS; ADAPTATION; VALIDATION;
PREVENTION; MILITARY
AB Background: Resilience Training has the potential to mitigate mental health symptoms when provided during initial military training. Methods: The present study examined the impact of Resilience Training on US soldier well-being and attitudes during Basic Combat Training. Platoons were randomly assigned to Resilience Training or Military History provided during the first few days of Basic Combat Training. Surveys were conducted at baseline, post-intervention, and 3, 6, and 9 weeks. Results: The sample resulted in a total of 1,939 soldiers who completed at least the baseline and one follow-up survey. There were no significant differences between conditions in terms of depression symptoms, anxiety symptoms, or sleep problems. However, while anxiety decreased in both conditions, the rate of decrease was faster in the Resilience Training condition. In contrast, Resilience Training had a slower rate of increase in group cohesion over time than the Military History condition. In addition, Resilience Training was associated with greater confidence in helping others and received more positive ratings than Military History. Conclusions: Findings demonstrate that the brief Resilience Training studied here may have some utility in supporting mental health and peer support but may not benefit unit climate.
C1 [Adler, Amy B.] US Army Med Res Unit Europe, Sembach, Germany.
[Williams, Jason] Res Triangle Inst, Res Triangle Pk, NC USA.
[McGurk, Dennis] Mil Operat Med Res Program, Med Res & Mat Command, Frederick, MD USA.
[Moss, Andrew] Australian Army, Mental Hlth & Psychol, Canberra, ACT, Australia.
[Bliese, Paul D.] Walter Reed Army Inst Res, Silver Spring, MD USA.
RP Adler, AB (reprint author), Ctr Mil Psychiat & Neurosci, Walter Reed Army Inst Res, Mil Psychiat Branch, Silver Spring, MD 20910 USA.
EM amy.b.adler.civ@mail.mil
FU Research Triangle Institute (RTI)
FX We thank Michael Wood, Michael Rinehart, Michael Hagan, Tracy Johnson,
Victor Martinez, Rachel Eckford, Angela Salvi, Steven Terry, Julie
Merrill, Louis Csoka, Tom Powers, Sonya Cable, Stephanie Muraca, and the
Research Triangle Institute (RTI) for their research support in the US
and David Morton, Stephanie Hodson, and Andrew Cohn for their research
support in the Australian Defence Force. The views expressed in this
article are those of the authors and do not necessarily represent the
official policy or position of the US Army Medical Command or the
Australian Defence Force.
NR 44
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U1 4
U2 12
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1758-0846
EI 1758-0854
J9 APPL PSYCHOL-HLTH WE
JI Appl. Psychol.-Health Well Being
PD MAR
PY 2015
VL 7
IS 1
BP 85
EP 107
DI 10.1111/aphw.12040
PG 23
WC Psychology, Applied
SC Psychology
GA CE5AC
UT WOS:000351841000006
PM 25641899
ER
PT J
AU Attatippaholkun, W
Pankhong, P
Nisalak, A
Kalayanarooj, S
AF Attatippaholkun, Watcharee
Pankhong, Panyupa
Nisalak, Ananda
Kalayanarooj, Smpen
TI Evolutionary relationship of 5 '-untranslated regions among Thai
dengue-3 viruses, Bangkok isolates, during 24 year-evolution
SO ASIAN PACIFIC JOURNAL OF TROPICAL MEDICINE
LA English
DT Article
DE Thai dengue-3 viruses; Evolutionary relationship; 5 ' untranslated
regions; 24 Year-evolution
ID RNA SECONDARY STRUCTURES; VIRAL REPLICATION; CODING REGION; GENOME;
PREDICTION; INFECTION; SEQUENCES; ELEMENTS
AB Objective: To study evolutionary relationship of the 5'untranslated regions (5'UTRs) in low passage dengue3 viruses (DEN3) isolated from hospitalized children with different clinical manifestations in Bangkok during 24 year-evolution (1977-2000) comparing to the DEN3 prototype (H87). Methods: The 5'UTRs of these Thai DEN3 and the H87 prototype were amplified by RT-PCR and sequenced. Their multiple sequence alignments were done by Codon Code Aligner v 4.0.4 software and their RNA secondary structures were predicted by MFOLD software. Replication of five Thai DEN3 candidates comparing to the H87 prototype were done in human (HepG2) and the mosquito (C6/36) cell lines. Results: Among these Thai DEN3, the completely identical sequences of their first 89 nucleotides, their high-order secondary structure of 5'UTRs and three SNPs including the predominant C90T, and two minor SNPs including A109G and A112G were found. The C90T of Thai DEN3, Bangkok isolates was shown predominantly before 1977. Five Thai DEN3 candidates with the predominant C90T were shown to replicate in human (HepG2) and the mosquito (C6/36) cell lines better than the H87 prototype. However, their highly conserved sequences as well as SNPs of the 5'UTR did not appear to correlate with their disease severity in human. Conclusions: Our findings highlighted evolutionary relationship of the completely identical 89 nucleotide sequence. the high-order secondary structure and the predominant C90T of the 5'UTR of these Thai DEN3 during 24 year-evolution further suggesting to be their genetic markers and magic targets for future research on antiviral therapy as well as vaccine approaches of Thai DEN3.
C1 [Attatippaholkun, Watcharee; Pankhong, Panyupa] Mahidol Univ, Fac Med Technol, Dept Clin Chem, Bangkok 10700, Thailand.
[Nisalak, Ananda] US Army Med Component, Armed Forces Res Inst Med Sci, Dept Virol, Bangkok 10400, Thailand.
[Kalayanarooj, Smpen] Queen Sirikit Natl Inst Child Hlth, Bangkok 10400, Thailand.
RP Attatippaholkun, W (reprint author), Mahidol Univ, Fac Med Technol, Dept Clin Chem, Bangkok 10700, Thailand.
EM mtwap@mahidol.ac.th
FU Program in Science and Technology Cooperation [493-5600-G-00-3461]
FX This work was supported by two research grants of Associate Professor
Dr. W. Attatippaholkun: Grant No.493-5600-G-00-3461, Program in Science
and Technology Cooperation. Human Capacity Development, Bureau for
Global Programs. Field Support and Research, US Agency for International
Development. Washington, DC and The Royal Golden Jubilee-Ph.D Program,
Thailand Research Fund, Thailand. The authors would like to thank Dr.
Bruce L. Innis, Dr. David W.Vaughn, Dr. Mammen P. Mammen, Jr. and Dr.
Timothy P. Endy for kindly providing all these Thai DEN3 isolates
studied in this project, which were maintained at Department of
Virology, The US Army Medical Component, Armed Forces Research Institute
of Medical Sciences (USAMC-AFRIMS), Bangkok, Thailand. Cell culture
analysis was supported by Professor Dr. David B. Weiner's laboratory,
University of Pennsylvania. Philadelphia, PA.
NR 34
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Z9 0
U1 0
U2 3
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1995-7645
J9 ASIAN PAC J TROP MED
JI Asian Pac. J. Trop. Med.
PD MAR
PY 2015
VL 8
IS 3
BP 176
EP 184
DI 10.1016/S1995-7645(14)60311-4
PG 9
WC Public, Environmental & Occupational Health; Tropical Medicine
SC Public, Environmental & Occupational Health; Tropical Medicine
GA CE5QW
UT WOS:000351891700002
PM 25902157
ER
PT J
AU Strandenes, G
Hervig, TA
Bjerkvig, CK
Williams, S
Eliassen, HS
Fosse, TK
Torvanger, H
Cap, AP
AF Strandenes, Geir
Hervig, Tor A.
Bjerkvig, Christopher K.
Williams, Steve
Eliassen, Hakon S.
Fosse, Theodor K.
Torvanger, Hans
Cap, Andrew P.
TI The Lost Art of Whole Blood Transfusion in Austere Environments
SO CURRENT SPORTS MEDICINE REPORTS
LA English
DT Review
ID IRREVERSIBLE HEMORRHAGIC SHOCK; DAMAGE CONTROL RESUSCITATION; TRAUMA
PATIENTS; IMPROVED SURVIVAL; OXYGEN DEFICIT; REQUIREMENT; MORTALITY;
PLATELETS; PRESSURE; PLASMA
AB The optimal resuscitation fluid for uncontrolled bleeding and hemorrhagic shock in both pre- and in-hospital settings has been an ongoing controversy for decades. Hemorrhage continues to be a major cause of death in both the civilian and military trauma population, and survival depends on adequacy of hemorrhage control and resuscitation between onset of bleeding and arrival at a medical treatment facility. The terms far-forward and austere are defined, respectively, as the environment where professional health care providers normally do not operate and a setting in which basic equipment and capabilities necessary for resuscitation are often not available. The relative austerity of a treatment setting may be a function of timing rather than just location, as life-saving interventions must be performed quickly before hemorrhagic shock becomes irreversible. Fresh whole blood transfusions in the field may be a feasible life-saving procedure when facing significant hemorrhage.
C1 [Strandenes, Geir] Norwegian Naval Special Operat Commando, Bergen, Norway.
[Strandenes, Geir; Hervig, Tor A.; Eliassen, Hakon S.] Haukeland Hosp, Dept Immunol & Transfus Med, N-5021 Bergen, Norway.
[Bjerkvig, Christopher K.; Fosse, Theodor K.; Torvanger, Hans] Haukeland Hosp, Dept Anesthesia & Intens Care, N-5021 Bergen, Norway.
[Williams, Steve] Med Operat Royal Caribbean Cruises Ltd, Miami, FL USA.
[Cap, Andrew P.] US Army, Inst Surg Res, Joint Base San Antonio F, TX USA.
RP Strandenes, G (reprint author), Haukeland Hosp, Dept Immunol & Transfus Med, N-5021 Bergen, Norway.
EM geir@docfish.no
NR 29
TC 1
Z9 1
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1537-890X
EI 1537-8918
J9 CURR SPORT MED REP
JI Curr. Sport. Med. Rep.
PD MAR-APR
PY 2015
VL 14
IS 2
BP 129
EP 134
DI 10.1249/JSR.0000000000000130
PG 6
WC Sport Sciences
SC Sport Sciences
GA CE2BS
UT WOS:000351618400014
PM 25757009
ER
PT J
AU Bar-Cohen, A
Matin, K
Jankowski, N
Sharar, D
AF Bar-Cohen, Avram
Matin, Kaiser
Jankowski, Nicholas
Sharar, Darin
TI Two-Phase Thermal Ground Planes: Technology Development and Parametric
Results
SO JOURNAL OF ELECTRONIC PACKAGING
LA English
DT Article
ID HIGH-HEAT-FLUX
AB Defense Advanced Research Project Agency's (DARPA's) thermal ground plane (TGP) effort was aimed at combining the advantages of vapor chambers or two-dimensional (2D) heat pipes and solid conductors by building thin, high effective thermal conductivity, flat heat pipes out of materials with thermal expansion coefficients that match current electronic devices. In addition to the temperature uniformity and minimal load-driven temperature variations associated with such two phase systems, in their defined parametric space, flat heat pipes are particularly attractive for Department of Defense and commercial systems because they offer a passive, reliable, light-weight, and low-cost path for transferring heat away from high power dissipative components. However, the difference in thermal expansion coefficients between silicon or ceramic microelectronic components and metallic vapor chambers, as well as the need for a planar, chip-size attachment surface for these devices, has limited the use of commercial of the shelf flat heat pipes in this role. The primary TGP goal was to achieve extreme lateral thermal conductivity, in the range of 10 kW/mK-20 kW/mK or approximately 25-50 times higher than copper and 10 times higher than synthetic diamond, with a thickness of 1 mm or less.
C1 [Bar-Cohen, Avram] DARPA, MTO, Arlington, VA 22203 USA.
[Matin, Kaiser] Syst Planning Corp, Arlington, VA 22201 USA.
[Jankowski, Nicholas] US Army Res Lab, Adelphi, MD 20783 USA.
[Sharar, Darin] Gen Tech Serv LLC, Wall Township, NJ 07719 USA.
RP Bar-Cohen, A (reprint author), DARPA, MTO, 675 North Randolph St, Arlington, VA 22203 USA.
EM abc@darpa.mil; kaiser.matin.ctr@darpa.mil;
Nicholas.Jankowski@us.army.mil; darin.j.sharar.ctr@mail.mil
FU DARPA's TGP program [BAA 7-36]
FX The authors want to acknowledge Dr. Thomas Kenny (former PM/MTO) for his
efforts in defining, initiating and guiding the early stages of DARPA's
TGP program, under BAA 7-36. We also want to thank Dr. Kristen Bloschock
currently at Lockheed Martin Corporation and the principal investigators
of the DARPA TGP program: Q. Cai from Teledyne, Scott Miller from GE,
David Altmen from Raytheon, Larry Greenberg from NG, Y. Sungtaek Ju from
UCLA, Albert Pisano from UC-Berkeley, Carl Meinhart from UCSB, and Y. C.
Lee from the University of Colorado-Boulder, for their contributions to
this paper.
NR 29
TC 5
Z9 5
U1 2
U2 9
PU ASME
PI NEW YORK
PA TWO PARK AVE, NEW YORK, NY 10016-5990 USA
SN 1043-7398
EI 1528-9044
J9 J ELECTRON PACKAGING
JI J. Electron. Packag.
PD MAR
PY 2015
VL 137
IS 1
AR 010801
DI 10.1115/1.4028890
PG 9
WC Engineering, Electrical & Electronic; Engineering, Mechanical
SC Engineering
GA CE2JR
UT WOS:000351642400001
ER
PT J
AU Ernst, M
Habtour, E
Dasgupta, A
Pohland, M
Robeson, M
Paulus, M
AF Ernst, Matthew
Habtour, Ed
Dasgupta, Abhijit
Pohland, Michael
Robeson, Mark
Paulus, Mark
TI Comparison of Electronic Component Durability Under Uniaxial and
Multiaxial Random Vibrations
SO JOURNAL OF ELECTRONIC PACKAGING
LA English
DT Article
DE multiaxial; nonlinear; vibration; fatigue; simultaneous loading
AB Multiaxial and uniaxial vibration experiments were conducted in order to study the differences in failure modes and fatigue life for the two types of excitation. An electrodynamic (ED) shaker capable of controlled vibration in six degrees of freedom (DOF) was employed for the experiments. The test specimen consisted of six large inductors insertion mounted on a printed wiring board (PWB). Average damage accumulation rate (DAR) in the inductor leads was measured for random excitations in-plane, out-of-plane, and both directions simultaneously. Under simultaneous multiaxial excitation, the average DAR was found to be 2.2 times greater than the sum of the in-plane and out-of-plane DARs. The conclusion was that multiple-step sequential uniaxial testing may significantly overestimate the durability of large/heavy structures with high center of mass in a multiaxial dynamic environment. Additionally, a test method utilizing uniaxial vibration along a direction other than the principal directions of the structure was examined. This method was found to have significant limitations, but showed better agreement with simultaneous multiaxial vibration experiments.
C1 [Ernst, Matthew] Johns Hopkins Univ, Appl Phys Lab, Laurel, MD 20723 USA.
[Habtour, Ed] US Army Res Lab, Vehicle Technol Directorate, Aberdeen Proving Ground, MD 21005 USA.
[Dasgupta, Abhijit] Univ Maryland, Ctr Adv Life Cycle Engn, College Pk, MD 20742 USA.
[Pohland, Michael] US Army Mat Syst Act Anal, Aberdeen Proving Ground, MD 21005 USA.
[Robeson, Mark] US Armys Aviat Dev Directorate Ft Eustis, Ft Eustis, VA 23604 USA.
[Paulus, Mark] Naval Undersea Warfare Ctr, Keyport, WA 98345 USA.
RP Ernst, M (reprint author), Johns Hopkins Univ, Appl Phys Lab, Johns Hopkins Rd, Laurel, MD 20723 USA.
EM ernstm@gmail.com; ed.m.habtour.civ@mail.mil; dasgupta@umd.edu;
michael.f.pohland.civ@mail.mil; mark.e.robeson.civ@mail.mil;
mark.paulus@navy.mil
OI Habtour, Ed/0000-0002-9083-9285
FU Center for Advanced Life Cycle Engineering (CALCE) at the University of
Maryland; U.S. Army Research Laboratory; University of Maryland, College
Park, MD; Naval Undersea Warfare Center
FX This research effort was funded by the sponsors of the Center for
Advanced Life Cycle Engineering (CALCE) at the University of Maryland
and was further supported by a Collaborative Research and Development
Agreement (CRADA) between the U.S. Army Research Laboratory and the
University of Maryland, College Park, MD. We gratefully acknowledge the
continual support of Naval Undersea Warfare Center and for the unique
MDOF test setup provided by TEAM Inc. and Data Physics Inc.
NR 19
TC 4
Z9 4
U1 0
U2 14
PU ASME
PI NEW YORK
PA TWO PARK AVE, NEW YORK, NY 10016-5990 USA
SN 1043-7398
EI 1528-9044
J9 J ELECTRON PACKAGING
JI J. Electron. Packag.
PD MAR
PY 2015
VL 137
IS 1
AR 011009
DI 10.1115/1.4028516
PG 8
WC Engineering, Electrical & Electronic; Engineering, Mechanical
SC Engineering
GA CE2JR
UT WOS:000351642400010
ER
PT J
AU Fresconi, F
DeSpirito, J
Celmins, I
AF Fresconi, Frank
DeSpirito, James
Celmins, Ilmars
TI Flight Performance of a Small Diameter Munition with a Rotating Wing
Actuator
SO JOURNAL OF SPACECRAFT AND ROCKETS
LA English
DT Article
ID NAVIER-STOKES PREDICTIONS; CONTROLLED PROJECTILES; JET INTERACTION;
STABILITY; GUIDANCE
AB Future enhanced lethal effects at the infantry squad level likely include precision guided technologies. The focus of this study is maneuvering projectiles launched from man-portable weapon systems. Anovel guided projectile concept is proposed for achieving control authority requirements in the challenging environment of low-dynamic pressure, small size, high launch loads, spin stabilization, and low cost. This new maneuver concept is based on a rotating wing actuator. Experimental and advanced computational aerodynamics techniques were applied. Aerodynamic models and projectile flight mechanics were derived to enable flight simulation. Assessment of ballistic delivery accuracy, based on physics-based models of the delivery process, was undertaken to quantify control authority requirements. Maneuvering flight simulations demonstrated that this concept affords enough course correction to compensate for ballistic delivery errors.
C1 [Fresconi, Frank] US Army Res Lab, Weap & Mat Res Directorate, Precis & Guided Flight Dynam, RDRL WML E, Aberdeen Proving Ground, MD 21005 USA.
[DeSpirito, James; Celmins, Ilmars] US Army Res Lab, Weap & Mat Res Directorate, RDRL WML E, Aberdeen Proving Ground, MD 21005 USA.
RP Fresconi, F (reprint author), US Army Res Lab, Weap & Mat Res Directorate, Precis & Guided Flight Dynam, RDRL WML E, Aberdeen Proving Ground, MD 21005 USA.
FU U.S. Department of Defense (DoD)
FX The authors are grateful to the scientists, engineers, and technicians
from the Edgewood Chemical and Biological Center at the Aberdeen Proving
Ground for conducting wind-tunnel experiments. This work was performed
in part by a grant of high-performance computing time from the U.S.
Department of Defense (DoD) High Performance Computing Modernization
Program Supercompting Resource Centers at the U.S. Air Force Research
Laboratory, Wright-Paterson Air Force Base, OH; the U.S. Army Research
Laboratory, Aberdeen Proving Ground, MD; and the U.S. Army Engineer
Research and Development Center, Vicksburg, MS.
NR 36
TC 0
Z9 0
U1 1
U2 4
PU AMER INST AERONAUTICS ASTRONAUTICS
PI RESTON
PA 1801 ALEXANDER BELL DRIVE, STE 500, RESTON, VA 22091-4344 USA
SN 0022-4650
EI 1533-6794
J9 J SPACECRAFT ROCKETS
JI J. Spacecr. Rockets
PD MAR
PY 2015
VL 52
IS 2
BP 305
EP 319
DI 10.2514/1.A32931
PG 15
WC Engineering, Aerospace
SC Engineering
GA CE2CS
UT WOS:000351621400001
ER
PT J
AU Frank, RM
Parada, SA
Mascarenhas, R
Romeo, AA
AF Frank, Rachel M.
Parada, Stephen A.
Mascarenhas, Randy
Romeo, Anthony A.
TI When Allografts Fail for Instability Surgery-What to Do?
SO OPERATIVE TECHNIQUES IN SPORTS MEDICINE
LA English
DT Article
DE shoulder instability; allograft; revision stabilization; bone
augmentation
ID HILL-SACHS LESION; GLENOID BONE LOSS; ANTERIOR GLENOHUMERAL INSTABILITY;
PERIPROSTHETIC JOINT INFECTIONS; OSTEOCHONDRAL ALLOGRAFTS;
OSTEOARTICULAR ALLOGRAFT; SHOULDER ARTHROPLASTY; FOLLOW-UP;
RECONSTRUCTION; MANAGEMENT
AB The glenohumeral joint is a highly congruous articulation that is dependent on the osseous integrity of both the glenoid rim and the humeral head. Disruptions in the bony architecture of either surface occur in up to 100% of shoulders in the setting of recurrent anterior shoulder instability. Unrecognized, as well as underappreciated, glenoid bone loss in the setting of glenohumeral instability is especially problematic. As bone loss approaches 20% or more of the glenoid surface area, surgical strategies tend to incorporate a bony reconstruction, with either an autograft or an allograft. Similarly, bone defects of greater than 25%-30% of the humeral head tend to warrant surgical treatment; although often in this setting, reconstruction of the glenoid restores smooth articulation with the humeral head, despite the defect, and no further treatment is required. Although short-term outcomes following allograft reconstruction of the glenohumeral joint are encouraging, given the relatively few medium- and long-term reports available, it is difficult to draw conclusions as to how these procedures fare over time. Cases of recurrent instability despite appropriate allograft reconstruction exist, and surgical options are typically salvage-type procedures, limited to revision allograft reconstruction or arthroplasty. This review focuses on the indications for allograft reconstruction of the glenohumeral joint, definition of and workup of patients experiencing recurrent instability following allograft augmentation, and treatment options for these difficult patients. A treatment algorithm summarizing the authors recommended management of these patients has also been provided. (C) 2015 Elsevier Inc. All rights reserved.
C1 [Frank, Rachel M.; Mascarenhas, Randy; Romeo, Anthony A.] Rush Univ, Med Ctr, Dept Orthopaed Surg, Chicago, IL 60612 USA.
[Parada, Stephen A.] Uniformed Serv Univ Hlth Sci, Eisenhower Army Med Ctr, Dept Orthopaed, Ft Gordon, GA USA.
RP Frank, RM (reprint author), Rush Univ, Med Ctr, Dept Orthopaed Surg, 1611 W Harrison St Suite 200, Chicago, IL 60612 USA.
EM rmfrank3@gmail.com
OI Romeo, Anthony/0000-0003-4848-3411
NR 48
TC 0
Z9 0
U1 1
U2 1
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 1060-1872
EI 1557-9794
J9 OPER TECHN SPORT MED
JI Oper. Tech. Sports Med.
PD MAR
PY 2015
VL 23
IS 1
BP 43
EP 51
DI 10.1053/j.otsm.2014.10.002
PG 9
WC Sport Sciences; Surgery
SC Sport Sciences; Surgery
GA CE4FN
UT WOS:000351786600007
ER
PT J
AU DeRosa, R
Lustik, MB
Stackhouse, DA
McMann, LP
AF DeRosa, Raffaella
Lustik, Michael B.
Stackhouse, Danielle A.
McMann, Leah P.
TI Impact of the 2012 American Urological Association Vasectomy Guidelines
on Postvasectomy Outcomes in a Military Population
SO UROLOGY
LA English
DT Article
ID SEMEN ANALYSIS; SPERM; CANCER; NUMBER; RATES; TIME; MEN
AB OBJECTIVE To evaluate the impact of the 2012 American Urological Association vasectomy guidelines on postvasectomy clinical outcomes in a highly mobile military cohort and compare these outcomes with those of civilian counterparts.
METHODS The records of service members who underwent vasectomy between January 2008 and December 2013 and provided at least 1 postvasectomy semen analysis (PVSA) were analyzed in the context of the 2012 guidelines. Time to occlusive success, repeat PVSAs and vasectomies, and health care cost savings were compared between our prior definition of vasectomy success, which required azoospermia, and the 2012 criteria, which included rare nonmotile sperm.
RESULTS Of the 1623 men who underwent vasectomy, 738 men (45%) failed to submit a PVSA, leaving 895 men (55%) who provided at least 1 PVSA. A total of 1084 PVSAs were obtained in these men, who had a mean age of 37 +/- 6 years. Defining success as azoospermia on first PVSA resulted in a sterility rate of 69%. After application of the 2012 guidelines, 845 patients (94%) achieved sterility by the first PVSA and more patients achieved sterility 60 days from vasectomy (96% vs 72%; P < .001). Inclusion of rare nonmotile sperm in our definition of success would have allowed 228 men to forego a second PVSA and prevented 2 (0.002%) unnecessary vasectomies, a savings of $6297.
CONCLUSION PVSA compliance in our military cohort was similar to that of civilian counterparts. The American Urological Association vasectomy guidelines have the potential to decrease the number of repeat vasectomies and laboratory tests, improve the documented success rate, and increase follow-up compliance when applied to a military population. Published by Elsevier Inc.
C1 [DeRosa, Raffaella] Tripler Army Med Ctr, Div Urol, Dept Surg, Honolulu, HI 96859 USA.
Tripler Army Med Ctr, Dept Clin Invest, Honolulu, HI 96859 USA.
RP DeRosa, R (reprint author), Tripler Army Med Ctr, Div Urol, Dept Surg, 1 Jarrett White Rd, Honolulu, HI 96859 USA.
EM Raffaella.Derosa.mil@mail.mil
NR 19
TC 2
Z9 2
U1 0
U2 1
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0090-4295
EI 1527-9995
J9 UROLOGY
JI Urology
PD MAR
PY 2015
VL 85
IS 3
BP 505
EP 510
DI 10.1016/j.urology.2014.11.010
PG 6
WC Urology & Nephrology
SC Urology & Nephrology
GA CE6JJ
UT WOS:000351942400011
PM 25559727
ER
PT J
AU Corbin, C
AF Corbin, Christophe
TI Universities in France: functioning and issues
SO FRENCH REVIEW
LA French
DT Book Review
C1 [Corbin, Christophe] US Mil Acad, West Point, NY 10996 USA.
RP Corbin, C (reprint author), US Mil Acad, West Point, NY 10996 USA.
NR 1
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC TEACHERS FRENCH
PI CARBONDALE
PA MAILCODE 4510, SOUTHERN ILLINOIS UNIV, CARBONDALE, IL 62901-4510 USA
SN 0016-111X
EI 2329-7131
J9 FR REV
JI Fr. Rev.
PD MAR
PY 2015
VL 88
IS 3
BP 237
EP 238
PG 2
WC Literature, Romance
SC Literature
GA CC8JB
UT WOS:000350613300048
ER
PT J
AU Yerry, JA
Kuehn, D
Finkel, AG
AF Yerry, Juanita A.
Kuehn, Devon
Finkel, Alan G.
TI Onabotulinum Toxin A for the Treatment of Headache in Service Members
With a History of Mild Traumatic Brain Injury: A Cohort Study
SO HEADACHE
LA English
DT Article
DE traumatic brain injury; botulinum toxin; military; headache; migraine;
chronic migraine
ID POSTTRAUMATIC-STRESS-DISORDER; BOTULINUM TOXIN; US SOLDIERS; CHRONIC
MIGRAINE; DOUBLE-BLIND; CERVICOGENIC HEADACHE; NUMMULAR HEADACHE;
PROPHYLACTIC TREATMENT; INTERNATIONAL BURDEN; MILITARY PERSONNEL
AB ObjectivePost-traumatic headache (PTH) of the migraine type is a common complication of mild traumatic brain injury (including blast injuries) in active duty service members. Persistent and near-daily headache occur. Usual preventive medications may have unacceptable side effects. Anecdotal reports suggest that onabotulinum toxin A (OBA) might be an effective treatment in these patients.
MethodsThis study is a real-time retrospective consecutive case series of all patients treated with OBA at the Concussion Care Clinic of Womack Army Medical Center, Ft. Bragg, NC, between August 2008 and August 2012. Clinical treatment and pharmacy records were corroborated with the electronic medical records in the Armed Forces Health Longitudinal Technology Application to determine demographics, current headache and treatment characteristics, and clinical and occupational outcomes.
ResultsSixty-four subjects (63 male) with mean age of 31.3 +/- 7.5 (range 20-59) years were evaluated and treated. Blast injuries were most common (n=36; 56.3%) and 7 patients (11%) reported a prior history of headache. Most patients (36; 56.3%) described more than 1 headache type and 48 (75%) patients had continuous pain. The most prevalent treating diagnosis was mixed continuous headache with migraine features on more than 15 days per month (n=26; 40.6%). The mean time from injury to the first injections was 10.8 +/- 21.9 (1-96) months. Forty (62.5%) patients received the Food and Drug Administration-approved chronic migraine injection protocol. Forty-one (64%) patients reported being better. Two patients discontinued for side effects. Twenty-seven (41%) remained on active duty.
ConclusionsWe demonstrate that active duty military patients with headaches related to concussions may benefit from treatment with OBA. Further studies are indicated.
C1 [Yerry, Juanita A.; Kuehn, Devon; Finkel, Alan G.] Womack Army Med Ctr, Dept Brain Injury Med, Ft Bragg, NC USA.
[Finkel, Alan G.] Def & Vet Brain Injury Ctr, Silver Spring, MD USA.
[Finkel, Alan G.] Carolina Headache Inst, Chapel Hill, NC USA.
RP Finkel, AG (reprint author), Carolina Headache Inst, Headache Med, 6114 Fayetteville Rd, Durham, NC 27713 USA.
EM finkela@chi09.com
FU Defense and Veteran Brain Injury Centers
FX One of the authors (AF) received salary support from the Defense and
Veteran Brain Injury Centers in the conduct of this study and
preparation of the manuscript. The views expressed herein are those of
the presenters and do not reflect the official policy of the Department
of the Army, Department of Defense, or the U.S. Government.
NR 71
TC 11
Z9 11
U1 1
U2 2
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0017-8748
EI 1526-4610
J9 HEADACHE
JI Headache
PD MAR
PY 2015
VL 55
IS 3
BP 395
EP 406
DI 10.1111/head.12495
PG 12
WC Clinical Neurology
SC Neurosciences & Neurology
GA CD6AS
UT WOS:000351171200004
PM 25644249
ER
PT J
AU Dietlein, CR
Bedair, SS
Pulskamp, JS
Meyer, CD
Polcawich, RG
AF Dietlein, Charles R.
Bedair, Sarah S.
Pulskamp, Jeffrey S.
Meyer, Christopher D.
Polcawich, Ronald G.
TI Microfabricated Thick-Cu PZT-MEMS Millimeter-Wave Topologies and Devices
SO IEEE MICROWAVE AND WIRELESS COMPONENTS LETTERS
LA English
DT Article
DE MEMS; microfabrication; millimeter-wave; phase shifters; PZT; switches;
transmission lines
ID INDUCTORS
AB This letter reports the design, fabrication, and performance of millimeter-wave transmission lines and devices in a tri-layer thick-copper (Cu) process. Beneath the Cu layers is a low-voltage lead zirconium titanate (PZT) MEMS stackup atop a nitride membrane, on high-resistivity silicon. The 10 mu m thick Cu layers enable several transmission-line topologies, and the PZT-MEMS functionality enables tunability. We designed transmission lines and un-optimized noncontact distributed MEMS transmission line (DMTL) phase shifters for 75-110 GHz, and present static measurements here. Simulation and measurements are in close agreement, with measured CPW line loss 0.15 dB greater than simulated (0.27 dB/mm at 95 GHz). Excess loss is attributed to Cu roughness, conductivity, and membrane/strap supports. Measured noncontact DMTL phase shifters exhibit a mean of 40 degrees/dB when intrinsic line loss is subtracted.
C1 [Dietlein, Charles R.; Bedair, Sarah S.; Pulskamp, Jeffrey S.; Meyer, Christopher D.; Polcawich, Ronald G.] US Army Res Lab, Adelphi, MD 20783 USA.
RP Dietlein, CR (reprint author), US Army Res Lab, Adelphi, MD 20783 USA.
EM charles.r.dietlein.civ@mail.mil
NR 10
TC 1
Z9 1
U1 1
U2 9
PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
PI PISCATAWAY
PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA
SN 1531-1309
EI 1558-1764
J9 IEEE MICROW WIREL CO
JI IEEE Microw. Wirel. Compon. Lett.
PD MAR
PY 2015
VL 25
IS 3
BP 163
EP 165
DI 10.1109/LMWC.2015.2391993
PG 3
WC Engineering, Electrical & Electronic
SC Engineering
GA CE0AG
UT WOS:000351463200007
ER
PT J
AU Hamed, AM
Jayakumar, P
Letherwood, MD
Gorsich, DJ
Recuero, AM
Shabana, AA
AF Hamed, Ashraf M.
Jayakumar, Paramsothy
Letherwood, Michael D.
Gorsich, David J.
Recuero, Antonio M.
Shabana, Ahmed A.
TI Ideal Compliant Joints and Integration of Computer Aided Design and
Analysis
SO JOURNAL OF COMPUTATIONAL AND NONLINEAR DYNAMICS
LA English
DT Article
DE compliant joints; tracked vehicle; flexible multibody systems; finite
element; ANCF; closed loop chains; I-CAD-A
ID NODAL COORDINATE FORMULATION; MULTIBODY TRACKED VEHICLES; SPATIAL
DYNAMICS; DEFORMABLE BEAM; FLOATING FRAME; ELEMENT; EQUATIONS;
CONSTRAINTS; FORCES
AB This paper discusses fundamental issues related to the integration of computer aided design and analysis (I-CAD-A) by introducing a new class of ideal compliant joints that account for the distributed inertia and elasticity. The absolute nodal coordinate formulation (ANCF) degrees of freedom are used in order to capture modes of deformation that cannot be captured using existing formulations. The ideal compliant joints developed can be formulated, for the most part, using linear algebraic equations, allowing for the elimination of the dependent variables at a preprocessing stage, thereby significantly reducing the problem dimension and array storage needed. Furthermore, the constraint equations are automatically satisfied at the position, velocity, and acceleration levels. When using the proposed approach to model large scale chain systems, differences in computational efficiency between the augmented formulation and the recursive methods are eliminated, and the central processing unit (CPU) times resulting from the use of the two formulations become similar regardless of the complexity of the system. The elimination of the joint constraint equations and the associated dependent variables also contribute to the solution of a fundamental singularity problem encountered in the analysis of closed loop chains and mechanisms by eliminating the need to repeatedly change the chain or mechanism independent coordinates. It is shown that the concept of the knot multiplicity used in computational geometry methods, such as B-spline and NURBS (nonuniform rational B-spline), to control the degree of continuity at the breakpoints is not suited for the formulation of many ideal compliant joints. As explained in this paper, this issue is closely related to the inability of B-spline and NURBS to model structural discontinuities. Another contribution of this paper is demonstrating that large deformation ANCF finite elements can be effective, in some multibody systems (MBS) applications, in solving small deformation problems. This is demonstrated using a heavily constrained tracked vehicle with flexible-link chains. Without using the proposed approach, modeling such a complex system with flexible links can be very challenging. The analysis presented in this paper also demonstrates that adding significant model details does not necessarily imply increasing the complexity of the MBS algorithm.
C1 [Hamed, Ashraf M.; Recuero, Antonio M.; Shabana, Ahmed A.] Univ Illinois, Dept Mech & Ind Engn, Chicago, IL 60607 USA.
[Jayakumar, Paramsothy; Letherwood, Michael D.; Gorsich, David J.] US Army RDECOM TARDEC, Warren, MI 48397 USA.
RP Hamed, AM (reprint author), Univ Illinois, Dept Mech & Ind Engn, 842 West Taylor St, Chicago, IL 60607 USA.
FU U.S. Army Tank-Automotive Research, Development and Engineering Center
(TARDEC) [W911NF-07-D-0001]; Computational Dynamics Inc.
FX This research was supported, in part, by the U.S. Army Tank-Automotive
Research, Development and Engineering Center (TARDEC) (Contract No.
W911NF-07-D-0001), and by Computational Dynamics Inc.
NR 38
TC 4
Z9 4
U1 1
U2 16
PU ASME
PI NEW YORK
PA TWO PARK AVE, NEW YORK, NY 10016-5990 USA
SN 1555-1423
EI 1555-1415
J9 J COMPUT NONLIN DYN
JI J. Comput. Nonlinear Dyn.
PD MAR
PY 2015
VL 10
IS 2
AR 021015
DI 10.1115/1.4027999
PG 14
WC Engineering, Mechanical; Mechanics
SC Engineering; Mechanics
GA CD8MQ
UT WOS:000351349700015
ER
PT J
AU Pasiakos, SM
AF Pasiakos, Stefan M.
TI Metabolic Advantages of Higher Protein Diets and Benefits of Dairy Foods
on Weight Management, Glycemic Regulation, and Bone
SO JOURNAL OF FOOD SCIENCE
LA English
DT Article
DE body weight; bone; branched-chain amino acids; casein; muscle; whey
ID RANDOMIZED CONTROLLED-TRIAL; CONVENTIONAL HIGH-CARBOHYDRATE; RESTING
ENERGY-EXPENDITURE; CONTROLLED CLINICAL-TRIALS; OBESE PREMENOPAUSAL
WOMEN; FAT-FREE MASS; BODY-COMPOSITION; SKELETAL-MUSCLE; LOSS
MAINTENANCE; RESISTANCE EXERCISE
AB The Inst. of Medicine and World Health Organization have determined that 0.8 to 0.83 g protein center dot kg(-1)center dot d(-1) is the quantity of protein required to establish nitrogen balance in nearly all healthy individuals. However, consuming higher protein diets may be metabolically advantageous, particularly for overweight and obese adults attempting weight loss, and for physically active individuals such as athletes and military personnel. Studies have demonstrated that higher protein diets may spare lean body mass during weight loss, promote weight management, enhance glycemic regulation, and increase intestinal calcium absorption, which may result in long-term improvements in bone health. The extent to which higher protein diets are beneficial is largely attributed to the digestive and absorptive properties, and also to the essential amino acid (EAA) content of the protein. Proteins that are rapidly digested and absorbed likely contribute to the metabolic advantages conferred by consuming higher protein diets. The EAA profiles, as well as the digestive and absorptive properties of dairy proteins, such as whey protein and casein, are particularly advantageous because they facilitate a rapid, robust, and sustained delivery of EAAs to the periphery. This article reviews the scientific literature assessing metabolic advantages associated with higher protein diets on weight management, glycemic regulation, and bone, with emphasis given to studies evaluating the potential benefits associated with dairy.
C1 US Army Res Inst Environm Med, Mil Nutr Div, Natick, MA 01760 USA.
RP Pasiakos, SM (reprint author), US Army Res Inst Environm Med, Mil Nutr Div, Natick, MA 01760 USA.
EM stefan.pasiakos@us.army.mil
RI Pasiakos, Stefan/E-6295-2014
OI Pasiakos, Stefan/0000-0002-5378-5820
FU U.S. Army Medical Research and Material Command; Dairy Management Inc.
FX This work was supported by the U.S. Army Medical Research and Material
Command. The author has received funding from Dairy Management Inc. for
work not related to this project. No other conflicts of interest exist.
NR 119
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U2 41
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0022-1147
EI 1750-3841
J9 J FOOD SCI
JI J. Food Sci.
PD MAR
PY 2015
VL 80
SU 1
BP A2
EP A7
DI 10.1111/1750-3841.12804
PG 6
WC Food Science & Technology
SC Food Science & Technology
GA CD6UM
UT WOS:000351225100002
PM 25757894
ER
PT J
AU Melching, CS
Liang, J
Fleer, L
Wethington, D
AF Melching, Charles S.
Liang, Jin
Fleer, Lauren
Wethington, David
TI Modeling the water quality impacts of the separation of the Great Lakes
and Mississippi River basins for invasive species control
SO JOURNAL OF GREAT LAKES RESEARCH
LA English
DT Article
DE Dissolved oxygen; Nutrients; Water quality modeling; Lake Michigan;
Invasive species
ID OXYGEN
AB In 1900, the Chicago Sanitary and Ship Canal (CSSC) was opened to reverse the flow of the Chicago River and divert wastewater away from Lake Michigan and toward the Mississippi River. This reversal has been a public health success, but the CSSC and other components of the Chicago Area Waterway System (CAWS) have become conduits for invasive species to move between the Great Lakes and Mississippi River basins. The Great Lakes and Mississippi River Interbasin Study evaluated methods to prevent the migration of invasive species between the basins. The DUFLOW model was adapted to simulate water quality in the CAWS. This model is used to simulate conditions in the CAWS for the No Project (NP), Lakefront Separation (LS), and Midsystem Separation (MS) alternatives. Three representative water years (wet year, dry year, and normal year) are considered to compare the dissolved oxygen (DO) results and pollutant loads to Lake Michigan for the alternatives. The LS alternative results in large increases in noncompliance with DO standards with increases greater than 1000 h for several locations. The MS alternative results in large increases in noncompliance with DO standards in the waterways made stagnant by the placement of barriers with the Calumet-Sag Channel experiencing increases greater than 1000 h for nearly all locations evaluated. The loads to Lake Michigan for the MS alternative are greatly increased compared to the NP alternative with even the dry year modeled yielding loads of nitrogen, phosphorus, and chloride, 5.7, 0.73, and 150 million kg, respectively. (C) 2014 International Association for Great Lakes Research. Published by Elsevier B.V. All rights reserved.
C1 [Melching, Charles S.] Private Consultant, Greenfield, WI 53221 USA.
[Liang, Jin] Marquette Univ, Dept Civil Construct & Environm Engn, Milwaukee, WI 53201 USA.
[Fleer, Lauren; Wethington, David] US Army Corps Engn, Chicago, IL 60604 USA.
RP Melching, CS (reprint author), Private Consultant, 4030 W Edgerton Ave, Greenfield, WI 53221 USA.
EM steve.melching17@gmail.com
FU USGS [G11AP20226]; USACE [W912P6-12-0047]
FX The project described in this report was supported by Grant/Cooperative
Agreement Number G11AP20226 from the USGS and Contract Number
W912P6-12-0047 from the USACE. The contents of this report are solely
the responsibility of the authors and do not necessarily represent the
official views of the USGS or USACE. Mention of trade names or
commercial products in this report does not constitute their endorsement
by the U.S. Government.
NR 28
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U1 3
U2 19
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0380-1330
J9 J GREAT LAKES RES
JI J. Gt. Lakes Res.
PD MAR
PY 2015
VL 41
IS 1
BP 87
EP 98
DI 10.1016/j.jglr.2014.11.009
PG 12
WC Environmental Sciences; Limnology; Marine & Freshwater Biology
SC Environmental Sciences & Ecology; Marine & Freshwater Biology
GA CE2NA
UT WOS:000351651100009
ER
PT J
AU Whitehurst, SV
Lockrow, EG
Lendvay, TS
Propst, AM
Dunlow, SG
Rosemeyer, CJ
Gobern, JM
White, LW
Skinner, A
Buller, JL
AF Whitehurst, Sabrina V.
Lockrow, Ernest G.
Lendvay, Thomas S.
Propst, Anthony M.
Dunlow, Susan G.
Rosemeyer, Christopher J.
Gobern, Joseph M.
White, Lee W.
Skinner, Anna
Buller, Jerome L.
TI Comparison of Two Simulation Systems to Support Robotic-Assisted
Surgical Training: A Pilot Study (Swine Model)
SO JOURNAL OF MINIMALLY INVASIVE GYNECOLOGY
LA English
DT Article
DE da Vinci Surgical System; dV-Trainer; Robotic surgery; Simulation;
Virtual reality
ID LAPAROSCOPIC SURGERY; PERFORMANCE; VALIDATION; SKILLS; TOOL
AB Objective: To compare the efficacy of simulation-based training between the Mimic dV- Trainer and traditional dry lab da Vinci robot training.
Design: A prospective randomized study analyzing the performance of 20 robotics-naive participants. Participants were enrolled in an online da Vinci Intuitive Surgical didactic training module, followed by training in use of the da Vinci standard surgical robot. Spatial ability tests were performed as well. Participants were randomly assigned to 1 of 2 training conditions: performance of 3 Fundamentals of Laparoscopic Surgery dry lab tasks using the da Vinci or performance of 4 dV-Trainer tasks. Participants in both groups performed all tasks to empirically establish proficiency criterion. Participants then performed the transfer task, a cystotomy closure using the daVinci robot on a live animal (swine) model. The performance of robotic tasks was blindly assessed by a panel of experienced surgeons using objective tracking data and using the validated Global Evaluative Assessment of Robotic Surgery (GEARS), a structured assessment tool.
Results: No statistically significant difference in surgeon performance was found between the 2 training conditions, dV-Trainer and da Vinci robot. Analysis of a 95% confidence interval for the difference in means (-0.803 to 0.543) indicated that the 2 methods are unlikely to differ to an extent that would be clinically meaningful.
Conclusion: Based on the results of this study, a curriculum on the dV- Trainer was shown to be comparable to traditional da Vinci robot training. Therefore, we have identified that training on a virtual reality system may be an alternative to live animal training for future robotic surgeons. Published by Elsevier Inc. on behalf of AAGL.
C1 [Whitehurst, Sabrina V.; Dunlow, Susan G.; Gobern, Joseph M.] Walter Reed Natl Mil Med Ctr, Dept Obstet & Gynecol, Bethesda, MD USA.
[Lockrow, Ernest G.; Propst, Anthony M.; Buller, Jerome L.] Uniformed Serv Univ Hlth Sci, Dept Obstet & Gynecol, Bethesda, MD 20814 USA.
[Lendvay, Thomas S.] Seattle Childrens Hosp, Dept Urol, Seattle, WA USA.
[Rosemeyer, Christopher J.] Tripler Army Med Ctr, Dept Obstet & Gynecol, Honolulu, HI 96859 USA.
[White, Lee W.] Univ Washington, Dept Bioengn, Seattle, WA 98195 USA.
[Skinner, Anna] Anthotronix, Silver Spring, MD USA.
RP Lockrow, EG (reprint author), Uniformed Serv Univ Hlth Sci, Dept Obstet & Gynecol, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA.
EM ernest.lockrow@usuhs.edu
FU AMEDD Advanced Medical Technology Initiative under the Medical Research
and Material Command, Telemedicine and Advanced Technology Research
Center
FX Funding was provided by a research grant from the AMEDD Advanced Medical
Technology Initiative under the Medical Research and Material Command,
Telemedicine and Advanced Technology Research Center. The opinions or
assertions contained herein are the private views of the authors and are
not to be construed as official or as reflecting the views of the US
Department of the Army, Department of the Navy, Department of the Air
Force, or Department of Defense.
NR 14
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U1 0
U2 4
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1553-4650
EI 1553-4669
J9 J MINIM INVAS GYN
JI J. Mimim. Invasive Gynecol.
PD MAR-APR
PY 2015
VL 22
IS 3
BP 483
EP 488
DI 10.1016/j.jmig.2014.12.160
PG 6
WC Obstetrics & Gynecology
SC Obstetrics & Gynecology
GA CE0FZ
UT WOS:000351481200028
PM 25543068
ER
PT J
AU Brooks, JR
Kerick, SE
McDowell, K
AF Brooks, Justin R.
Kerick, Scott E.
McDowell, Kaleb
TI Novel Measure of Driver and Vehicle Interaction Demonstrates Transient
Changes Related to Alerting
SO JOURNAL OF MOTOR BEHAVIOR
LA English
DT Article
DE alerting; driving behavior; sensorimotor transformation; steering wheel;
time on task; visuomotor
ID AUDITORY WARNING SIGNALS; VIGILANCE DECREMENT; STEERING CONTROL;
FATIGUE; DROWSINESS; ATTENTION; TASK; EEG; MINDLESSNESS; PERFORMANCE
AB Driver behavior and vehicle-road kinematics have been shown to change over prolonged periods of driving; however, the interaction between these two indices has not been examined. Here we develop a measure that examines how drivers turn the steering wheel relative to heading error velocity, which the authors call the relative steering wheel compensation (RSWC). The RSWC transiently changes on a short time scale coincident with a verbal query embedded within the study paradigm. In contrast, more traditional variables are dynamic over longer time scales consistent with previous research. The results suggest drivers alter their behavioral output (steering wheel correction) relative to sensory input (vehicle heading error velocity) on a distinct temporal scale and may reflect an interaction of alerting and control.
C1 [Brooks, Justin R.; Kerick, Scott E.; McDowell, Kaleb] Army Res Lab, Human Res & Engn Directorate, Aberdeen Proving Ground, MD 21005 USA.
[Brooks, Justin R.] Univ Maryland, Sch Med, Dept Med, College Pk, MD USA.
RP Brooks, JR (reprint author), Army Res Lab, Human Res & Engn Directorate, Attn RDRL HRS C, Aberdeen Proving Ground, MD 21005 USA.
EM jrybrooks@gmail.com
FU U.S. Department of the Army; Oak Ridge Associated Universities; Army
Research Laboratory [W911NF-12-2-0019]
FX This work was funded by the U.S. Department of the Army and Oak Ridge
Associated Universities. Research was sponsored by the Army Research
Laboratory and was accomplished under Cooperative Agreement Number
W911NF-12-2-0019. The views and conclusions contained in this document
are those of the authors and should not be interpreted as representing
official policies, either expressed or implied, of the Army Research
Laboratory or the U.S. Government. The U.S. Government is authorized to
reproduce and distribute reprints for Government purposes
notwithstanding any copyright notation herein.
NR 37
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U1 4
U2 13
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND
SN 0022-2895
EI 1940-1027
J9 J MOTOR BEHAV
JI J. Mot. Behav.
PD MAR-APR
PY 2015
VL 47
IS 2
BP 106
EP 116
DI 10.1080/00222895.2014.959887
PG 11
WC Neurosciences; Psychology; Psychology, Experimental; Sport Sciences
SC Neurosciences & Neurology; Psychology; Sport Sciences
GA CD8MO
UT WOS:000351349500006
PM 25356659
ER
PT J
AU Hagen, L
Hebert, JJ
Dekanich, J
Koppenhaver, S
AF Hagen, Lindsey
Hebert, Jeffrey J.
Dekanich, Joel
Koppenhaver, Shane
TI The Effect of Elastic Therapeutic Taping on Back Extensor Muscle
Endurance in Patients With Low Back Pain: A Randomized, Controlled,
Crossover Trial
SO JOURNAL OF ORTHOPAEDIC & SPORTS PHYSICAL THERAPY
LA English
DT Article
DE Biering-Sorensen test; lumbar spine; paraspinals
ID RELIABILITY; DISABILITY; VALIDITY; SCALE
AB STUDY DESIGN: Randomized, controlled, crossover trial.
OBJECTIVES: To examine the effects of elastic therapeutic taping (ETT) applied to the lumbar paraspinal region on back muscle endurance (BME) compared to no tape or a rigid therapeutic taping (RTT) procedure in individuals with nonspecific low back pain.
BACKGROUND: Elastic therapeutic taping is an increasingly popular intervention for clinicians who treat patients with low back pain. However, no studies have investigated the effect of ETT on back extensor muscle performance in a symptomatic population.
METHODS: We measured BME in 16 patients (mean +/- SD age, 44.8 +/- 10.4 years; 44% female) with nonspecific low back pain. Back muscle endurance was measured using the Biering-Sorensen test under 3 different conditions: ETT, no tape, and RTT. For the ETT condition, the tape was applied over the paraspinal muscles according to the Kinesio Tex taping protocol. The RTT condition consisted of the same tape configuration but using nonelastic athletic tape. All participants received each testing condition in random order, with 1 to 3 days between each condition. Differences in BME between the 3 testing conditions were explored with repeated-measures analyses of variance.
RESULTS: There were no differences in BME between ETT and RTT, or between the RTT and no-tape conditions. The difference in BME between the ETT and no-tape conditions was statistically significant (mean difference, 20.7 seconds; 95% confidence interval: 6.8, 34.5; P = .006) but within the threshold of measurement error.
CONCLUSION: Back muscle endurance was higher with ETT applied over the paraspinal musculature when compared to a no-tape condition. However, the magnitude of difference did not exceed measurement error. There was no difference in BME when using elastic or rigid therapeutic tape.
C1 [Hagen, Lindsey] Broadway Phys Therapy & Sports Rehabil, Portland, OR USA.
[Hebert, Jeffrey J.; Koppenhaver, Shane] Murdoch Univ, Sch Psychol & Exercise Sci, Murdoch, WA 6150, Australia.
[Dekanich, Joel] Vail Integrat Med Grp, Edwards, CO USA.
[Koppenhaver, Shane] US Army Baylor Univ Doctoral Program Phys Therapy, Ft Sam Houston, TX USA.
RP Hagen, L (reprint author), 3016 Northeast Broadway, Portland, OR 97232 USA.
EM lindseyfitch6@gmail.com
OI Hebert, Jeffrey/0000-0002-6959-325X
NR 17
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U1 1
U2 17
PU J O S P T,
PI ALEXANDRIA
PA 1111 NORTH FAIRFAX ST, STE 100, ALEXANDRIA, VA 22314-1436 USA
SN 0190-6011
J9 J ORTHOP SPORT PHYS
JI J. Orthop. Sports Phys. Ther.
PD MAR
PY 2015
VL 45
IS 3
BP 215
EP 219
DI 10.2519/jospt.2015.5177
PG 5
WC Orthopedics; Rehabilitation; Sport Sciences
SC Orthopedics; Rehabilitation; Sport Sciences
GA CD7EI
UT WOS:000351253200010
PM 25679343
ER
PT J
AU Flautt, W
Westrick, R
AF Flautt, Warren
Westrick, Richard
TI Cervical Myelopathy in a Special Operations Soldier
SO JOURNAL OF ORTHOPAEDIC & SPORTS PHYSICAL THERAPY
LA English
DT Editorial Material
C1 [Flautt, Warren] US Army Special Operat Command, Rehabil Program THOR3, Stuttgart, Germany.
[Westrick, Richard] US Army Res Inst Environm Med, Environm Med Branch, Natick, MA USA.
RP Flautt, W (reprint author), US Army Special Operat Command, Rehabil Program THOR3, Stuttgart, Germany.
NR 0
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U2 0
PU J O S P T,
PI ALEXANDRIA
PA 1111 NORTH FAIRFAX ST, STE 100, ALEXANDRIA, VA 22314-1436 USA
SN 0190-6011
J9 J ORTHOP SPORT PHYS
JI J. Orthop. Sports Phys. Ther.
PD MAR
PY 2015
VL 45
IS 3
BP 233
EP 233
DI 10.2519/jospt.2015.0403
PG 1
WC Orthopedics; Rehabilitation; Sport Sciences
SC Orthopedics; Rehabilitation; Sport Sciences
GA CD7EI
UT WOS:000351253200012
PM 25726697
ER
PT J
AU Hack, DC
AF Hack, Dallas C.
TI Foreword
SO MILITARY MEDICINE
LA English
DT Editorial Material
C1 US Army Med Res & Mat Command, Combat Casualty Care Res Program Chair, Joint Program Comm 6, Ft Detrick, MD 21702 USA.
RP Hack, DC (reprint author), US Army Med Res & Mat Command, Combat Casualty Care Res Program Chair, Joint Program Comm 6, Ft Detrick, MD 21702 USA.
NR 0
TC 0
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U1 0
U2 0
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
EI 1930-613X
J9 MIL MED
JI Milit. Med.
PD MAR
PY 2015
VL 180
IS 3
SU S
BP 1
EP 1
DI 10.7205/MILMED-D-14-00648
PG 1
WC Medicine, General & Internal
SC General & Internal Medicine
GA CD3OQ
UT WOS:000350988500001
PM 25747620
ER
PT J
AU Doll, BA
AF Doll, Bruce A.
TI Untitled
SO MILITARY MEDICINE
LA English
DT Editorial Material
C1 [Doll, Bruce A.] US Army Med Res & Mat Command, Ft Detrick, MD 21702 USA.
[Doll, Bruce A.] US Army Med Res & Mat Command, Def Hlth Agcy, Res Dev & Acquisit Directorate, Ft Detrick, MD 21702 USA.
RP Doll, BA (reprint author), US Army Med Res & Mat Command, 810 Schreider St, Ft Detrick, MD 21702 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
EI 1930-613X
J9 MIL MED
JI Milit. Med.
PD MAR
PY 2015
VL 180
IS 3
SU S
BP 2
EP 3
DI 10.7205/MILMED-D-14-00658
PG 2
WC Medicine, General & Internal
SC General & Internal Medicine
GA CD3OQ
UT WOS:000350988500002
PM 25747621
ER
PT J
AU Reilly, PA
Hatzfeld, JJ
AF Reilly, Patricia A.
Hatzfeld, Jennifer J.
TI 2013 Military Health System Research Symposium Supplement: Issue
Overview
SO MILITARY MEDICINE
LA English
DT Editorial Material
C1 [Reilly, Patricia A.] US Army Med Res & Mat Command, Off Principal Assistant Acquisit, Ft Detrick, MD 21702 USA.
[Hatzfeld, Jennifer J.] Combat Casualty Care Res Program, Joint Program Comm 6, Ft Detrick, MD 21702 USA.
RP Reilly, PA (reprint author), US Army Med Res & Mat Command, Off Principal Assistant Acquisit, 810 Schreider St, Ft Detrick, MD 21702 USA.
NR 0
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U1 0
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PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
EI 1930-613X
J9 MIL MED
JI Milit. Med.
PD MAR
PY 2015
VL 180
IS 3
SU S
BP 4
EP 7
DI 10.7205/MILMED-D-14-00672
PG 4
WC Medicine, General & Internal
SC General & Internal Medicine
GA CD3OQ
UT WOS:000350988500003
PM 25747622
ER
PT J
AU Dukes, S
Tourtillott, B
Bryant, D
Carter, K
McNair, S
Maupin, G
Tamminga, C
AF Dukes, Susan
Tourtillott, Brandon
Bryant, Devin
Carter, Kristina
McNair, Shanelle
Maupin, Genny
Tamminga, Cindy
TI Finishing What Was Started: An Analysis of Theater Research Conducted
From 2010 to 2012
SO MILITARY MEDICINE
LA English
DT Article; Proceedings Paper
CT Military Health Systems Research Symposium (MHSRS)
CY AUG 13-16, 2012
CL Fort Lauderdale, FL
AB The Joint Combat Casualty Research Team (JC2RT) is part of the human research protection regulatory system implemented in 2005 to oversee the conduct of research in a deployed military combatant command. In 2010, SharePoint, a web-based tool, was established to track study documents. This study conducted by JC2RT no. 13 describes characteristics of research studies under the purview of the JC2RT from 2010 through 2012. Of the 83 research studies reviewed, 34% were completed, 32% were not completed, and 34% were still in progress. Target sample sizes ranged from 12 to 70,000, with 96% of the research studying U.S. military members. The design of 61% of the studies was prospective, 20% surveys, and 14% retrospective reviews. Approximately one-half of the studies were conducted at single sites. Eighty-four percent of the studies that finished an institutional review board (IRB) were completed, whereas a large number of studies never made it to IRB approval. Even after studies have gone through the rigorous process of scientific review and IRB approval some continue to struggle for years to be completed in the theater of operations. The JC2RT is committed to helping facilitate the ethical conduct of research during war.
C1 [Bryant, Devin] HQ USPACOM, Camp H M Smith, HI 96861 USA.
[Carter, Kristina] Navy Environm & Preventat Med Unit, San Diego, CA 92136 USA.
[McNair, Shanelle] US Army Inst Surg Res, Ft Sam Houston, TX 78234 USA.
[Tamminga, Cindy] Naval Med Res Ctr, Silver Spring, MD 20910 USA.
RP Dukes, S (reprint author), 711 Human Performance Wing,2510 5th St Bldg 840s, Wright Patterson AFB, OH 45433 USA.
FU USCENTCOM; U.S. Army Medical Research and Materiel Command IRB; U.S.
Army Institute of Surgical Research
FX The authors acknowledge the support of USCENTCOM, U.S. Army Medical
Research and Materiel Command IRB, U.S. Army Institute of Surgical
Research, previous JC2RT team members, and Elizabeth Krech.
NR 4
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U1 0
U2 3
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
EI 1930-613X
J9 MIL MED
JI Milit. Med.
PD MAR
PY 2015
VL 180
IS 3
SU S
BP 8
EP 13
DI 10.7205/MILMED-D-14-00393
PG 6
WC Medicine, General & Internal
SC General & Internal Medicine
GA CD3OQ
UT WOS:000350988500004
PM 25747623
ER
PT J
AU Petz, LN
Tyner, S
Barnard, E
Ervin, A
Mora, A
Clifford, J
Fowler, M
Bebarta, VS
AF Petz, Lawrence N.
Tyner, Stuart
Barnard, Ed
Ervin, Alicia
Mora, Alex
Clifford, John
Fowler, Marcie
Bebarta, Vikhyat S.
TI Prehospital and En Route Analgesic Use in the Combat Setting: A
Prospectively Designed, Multicenter, Observational Study
SO MILITARY MEDICINE
LA English
DT Article; Proceedings Paper
CT Military Health Systems Research Symposium (MHSRS)
CY AUG 13-16, 2012
CL Fort Lauderdale, FL
ID PAIN MANAGEMENT; TRAUMA ANALGESIA; CASUALTY CARE; KETAMINE; BATTLEFIELD;
MORPHINE; RELIEF; IRAQ; WAR
AB Background: Combat injuries result in acute, severe pain. Early use of analgesia after injury is known to be beneficial. Studies on prehospital analgesia in combat are limited and no prospectively designed study has reported the use of analgesics in the prehospital and en route care setting. Our objective was to describe the current use of prehospital analgesia in the combat setting. Methods: This prospectively designed, multicenter, observational, prehospital combat study was undertaken at medical treatment facilities (MTF) in Afghanistan between October 2012 and September 2013. It formed part of a larger study aimed at describing the use of lifesaving interventions in combat. On arrival at the MTF, trained on-site investigators enrolled eligible patients and completed standardized data capture forms, which included the name, dose, and route of administration of all prehospital analgesics, and the type of provider who administered the drug. Physiological data were retrospectively ascribed as soon as practicable. The study was prospectively approved by the Brooke Army Medical Center institutional review board. Results: Data were collected on 228 patients, with 305 analgesia administrations recorded. The predominant mechanism of injury was blast (50%), followed by penetrating (41%), and blunt (9%). The most common analgesic used was ketamine, followed by morphine. A combination of analgesics was given to 29% of patients; the most common combination was ketamine and morphine. Intravenous delivery was the most commonly used route (55%). Patients transported by the UK Medical Emergency Response Team (MERT) or U.S. Air Medical Evacuation (Dust-off) team were more likely to receive ketamine than those evacuated by U.S. Pararescue Jumpers (Pedro). Patients transported by Medical Emergency Response Team or Pedro were more likely to receive more than 1 drug. Patients who received only ketamine had a higher pulse rate (p < 0.005) and lower systolic blood pressure (p = 0.01) than other groups, and patients that received hydromorphone had a lower respiratory rate (p = 0.04). Conclusions: In our prospectively designed, multicenter, observational, prehospital combat study, ketamine was the most commonly used analgesic drug. The most frequently observed combination of drugs was ketamine and morphine. The intravenous route was used for 55% of drug administrations.
C1 [Petz, Lawrence N.; Clifford, John; Fowler, Marcie] US Army Inst Surg Res, San Antonio Mil Med Ctr, Battlefield Pain Management, Jbsa Ft Sam Houston, TX 78234 USA.
[Barnard, Ed; Ervin, Alicia; Mora, Alex; Bebarta, Vikhyat S.] US Army Inst Surg Res, San Antonio Mil Med Ctr, Air Force En Route Care Res Ctr, Jbsa Ft Sam Houston, TX 78234 USA.
[Tyner, Stuart] US Army Inst Surg Res, San Antonio Mil Med Ctr, Dept Emergency Med, Jbsa Ft Sam Houston, TX 78234 USA.
[Barnard, Ed] Inst Naval Med, Alverstoke PO12 2DL, England.
RP Petz, LN (reprint author), US Army Inst Surg Res, San Antonio Mil Med Ctr, Battlefield Pain Management, 3698 Chambers Pass, Jbsa Ft Sam Houston, TX 78234 USA.
RI bebarta, vikhyat/K-3476-2015
FU Air Force Medical Support Agency [EM-I-12-005]
FX This study was funded by Air Force Medical Support Agency (EM-I-12-005).
We thank the current and former members of the on-site Joint Combat
Casualty Research Team that helped to collect critical data to make this
study possible and John Jones of USAISR for statistical analysis
assistance.
NR 30
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PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
EI 1930-613X
J9 MIL MED
JI Milit. Med.
PD MAR
PY 2015
VL 180
IS 3
SU S
BP 14
EP 18
DI 10.7205/MILMED-D-14-00383
PG 5
WC Medicine, General & Internal
SC General & Internal Medicine
GA CD3OQ
UT WOS:000350988500005
PM 25747624
ER
PT J
AU Hinojosa-Laborde, C
Aden, JK
Goei, KA
Convertino, VA
AF Hinojosa-Laborde, Carmen
Aden, James K.
Goei, Kathleen A.
Convertino, Victor A.
TI Evidence for a Higher Risk of Hypovolemia-Induced Hemodynamic
Instability in Females: Implications for Decision Support During
Prehospital Triage
SO MILITARY MEDICINE
LA English
DT Article; Proceedings Paper
CT Military Health Systems Research Symposium (MHSRS)
CY AUG 13-16, 2012
CL Fort Lauderdale, FL
ID BODY NEGATIVE-PRESSURE; ORTHOSTATIC TOLERANCE; GENDER-DIFFERENCES;
CARDIOVASCULAR-RESPONSES; WOMEN; MODEL; SHOCK; HUMANS; LBNP; MEN
AB Lower body negative pressure (LBNP) simulates hemorrhage, and tolerance to LBNP (time to presyncope [TTP]) is indicative of tolerance to blood loss. The purpose of this study was to predict TTP based on demographic characteristics (sex, age, height, and body mass index) and physiological variables (heart rate [HR], systolic arterial pressure, diastolic arterial pressure [DAP], pulse pressure, stroke volume, total peripheral resistance [TPR], and baroreflex sensitivity [BRS]) at baseline, and during 2 levels of LBNP (-15, -30 mm Hg). Multiple linear regression analysis was used to create a model to predict TTP (range: 670 to 2516 seconds, n = 187) based on demographic characteristics and physiological variables changes (Delta) from baseline to -30 mm Hg LBNP. The prediction model revealed that TTP (seconds) = 1667.5 + (5.1 x Age) + (61.1 x Sex) - (21.5 x Delta HR) + (55.3 x Delta DAP) - (88.2 + Delta TPR) - (4.9 x Delta BRS). Most significantly, our analysis demonstrated a lesser survival trajectory for females given the same rate and magnitude of hemorrhage compared to males. Young age and female sex are predictors of low tolerance to blood loss, and should be considered for early triage in the prehospital setting.
C1 [Hinojosa-Laborde, Carmen; Aden, James K.; Convertino, Victor A.] US Army Inst Surg Res, Jbsa Ft Sam Houston, TX 78234 USA.
[Goei, Kathleen A.] Univ Incarnate Word, San Antonio, TX 78209 USA.
RP Hinojosa-Laborde, C (reprint author), US Army Inst Surg Res, 3698 Chambers Pass, Jbsa Ft Sam Houston, TX 78234 USA.
FU U.S. Army Medical Research and Materiel Command Combat Casualty Care
Research Program
FX This research was supported by funding from the U.S. Army Medical
Research and Materiel Command Combat Casualty Care Research Program.
NR 29
TC 0
Z9 0
U1 0
U2 2
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
EI 1930-613X
J9 MIL MED
JI Milit. Med.
PD MAR
PY 2015
VL 180
IS 3
SU S
BP 19
EP 23
DI 10.7205/MILMED-D-14-00394
PG 5
WC Medicine, General & Internal
SC General & Internal Medicine
GA CD3OQ
UT WOS:000350988500006
PM 25747625
ER
PT J
AU Mitchell, TA
Wallum, TE
Becker, TE
Aden, JK
Bailey, JA
Blackbourne, LH
White, CE
AF Mitchell, Thomas A.
Wallum, Timothy E.
Becker, Tyson E.
Aden, James K.
Bailey, Jeffrey A.
Blackbourne, Lorne H.
White, Christopher E.
TI Nonoperative Management of Splenic Injury in Combat: 2002-2012
SO MILITARY MEDICINE
LA English
DT Article; Proceedings Paper
CT Military Health Systems Research Symposium (MHSRS)
CY AUG 13-16, 2012
CL Fort Lauderdale, FL
ID TRAUMA
AB Background: Selective nonoperative management of combat-related blunt splenic injury (BSI) is controversial. We evaluated the impact of the November 2008 blunt abdominal trauma clinical practice guideline that permitted selective nonoperative management of some patients with radiological suggestion of hemoperitoneum on implementation of nonoperative management (NOM) of splenic injury in austere environments. Methods: Retrospective evaluation of patients with splenic injuries from November 2002 through January 2012 in Iraq and Afghanistan was performed. International Classification of Diseases, 9th Revision, Clinical Modification procedure codes identified patients as laparotomy with splenectomy, or NOM. Delayed operative management had no operative intervention at earlier North American Treaty Organization (NATO) medical treatment facilities (MTFs), and had a definitive intervention at a latter NATO MTFs. Intra-abdominal complications and overall mortality were juxtaposed. Results: A total of 433 patients had splenic injuries from 2002 to 2012. Initial NOM of BSI from 2002 to 2008 compared to 2009-2012 was 44.1% and 47.2%, respectively (p = 0.75). Delayed operative management and NOM completion had intra-abdominal complication and mortality rates of 38.1% and 9.1% (p < 0.01), and 6.3% and 8.1% (p = 0.77). Conclusions: Despite high-energy explosive injuries, NATO Role II MTFs radiological constraints and limited medical resources, hemodynamically normal patients with BSI and low abdominal abbreviated injury scores underwent NOM in austere environments.
C1 [Mitchell, Thomas A.; Becker, Tyson E.; Blackbourne, Lorne H.; White, Christopher E.] US Mil Gen Surg, San Antonio Mil Med Ctr, San Antonio, TX 78234 USA.
[Wallum, Timothy E.; Aden, James K.; Bailey, Jeffrey A.] US Army Inst Surg Res, Jbsa Ft Sam Houston, TX 78234 USA.
RP Mitchell, TA (reprint author), US Mil Gen Surg, San Antonio Mil Med Ctr, 3851 Roger Brooke Dr 3600, San Antonio, TX 78234 USA.
NR 9
TC 0
Z9 0
U1 1
U2 1
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
EI 1930-613X
J9 MIL MED
JI Milit. Med.
PD MAR
PY 2015
VL 180
IS 3
SU S
BP 29
EP 32
DI 10.7205/MILMED-D-14-00411
PG 4
WC Medicine, General & Internal
SC General & Internal Medicine
GA CD3OQ
UT WOS:000350988500008
PM 25747627
ER
PT J
AU Mitchell, TA
Waldrep, KB
Sams, VG
Wallum, TE
Blackbourne, LH
White, CE
AF Mitchell, Thomas A.
Waldrep, Kevin B.
Sams, Valerie G.
Wallum, Timothy E.
Blackbourne, Lorne H.
White, Christopher E.
TI An 8-Year Review of Operation Enduring Freedom and Operation Iraqi
Freedom Resuscitative Thoracotomies
SO MILITARY MEDICINE
LA English
DT Article; Proceedings Paper
CT Military Health Systems Research Symposium (MHSRS)
CY AUG 13-16, 2012
CL Fort Lauderdale, FL
ID TRAUMA
AB Background: Appropriate indications for resuscitative thoracotomy (RT) in an austere environment continue to evolve; the aim of this study was to determine survival and to analyze demographics of survivors within U.S. military personnel undergoing RT. Methods: A retrospective review was performed of all U.S. soldiers who underwent thoracotomy in theater during Operation Iraqi Freedom and Operation Enduring Freedom. After individualized review, patients in extremis or who lost pulses and had their thoracotomy performed within 10 minutes of arrival to the emergency department were included. The primary outcome was survival at final hospital discharge, and secondary outcomes included demographics associated with survival. Results: Between January 2003 and May 2010, 81 U.S. military personnel met inclusion criteria for RT in theater. As low as 6.7% (3/45) of patients receiving prehospital cardiopulmonary resuscitation were alive at final hospital discharge. Survival from RT after explosive/blast injury, penetrating (gunshot wound), and blunt trauma were 16.3% (8/49), 0% (0/28), and 0% (0/4), respectively. Patients with primary explosive/blast extremity trauma undergoing RT had a survival of 27.3% (6/22). Higher initial oxygen saturations, larger volume of crystalloids and blood products infused, and higher extremity abbreviated injury score were all associated with survival. Conclusions: Combat casualties who present pulseless or in extremis who were injured as a result of an explosive/blast injury mechanism resulting in a primary extremity injury may have a survival benefit from undergoing a RT in an austere environment.
C1 [Mitchell, Thomas A.; Waldrep, Kevin B.; Sams, Valerie G.; Blackbourne, Lorne H.; White, Christopher E.] US Mil Gen Surg, San Antonio Mil Med Ctr, San Antonio, TX 78234 USA.
[Wallum, Timothy E.] US Army Inst Surg Res, Jbsa Ft Sam Houston, TX 78234 USA.
RP Mitchell, TA (reprint author), US Mil Gen Surg, San Antonio Mil Med Ctr, 3851 Roger Brooke Dr 3600, San Antonio, TX 78234 USA.
FU U.S. Military
FX The authors acknowledge the Department of Defense Trauma Registry and
the Patient Administration Systems and Biostatistics Activity for
providing data for this study. We also thank Ms. Alison Ramsey for her
assistance with critical editing. The authors would like to disclose
that no external funds were used to finance this project, and the U.S.
Military was solely responsible for funding this research.
NR 13
TC 2
Z9 2
U1 0
U2 0
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
EI 1930-613X
J9 MIL MED
JI Milit. Med.
PD MAR
PY 2015
VL 180
IS 3
SU S
BP 33
EP 36
DI 10.7205/MILMED-D-14-00440
PG 4
WC Medicine, General & Internal
SC General & Internal Medicine
GA CD3OQ
UT WOS:000350988500009
PM 25747628
ER
PT J
AU Waters, JA
Lundy, JB
Aden, JK
Sine, CR
Buel, AR
Henderson, JL
Stewart, IJ
Cannon, JW
Batchinsky, A
Cancio, LC
Chung, KK
AF Waters, J. Alan
Lundy, Jonathan B.
Aden, James K.
Sine, Christy R.
Buel, Allison R.
Henderson, Jonathan L.
Stewart, Ian J.
Cannon, Jeremy W.
Batchinsky, Andriy
Cancio, Leopoldo C.
Chung, Kevin K.
TI A Comparison of Acute Respiratory Distress Syndrome Outcomes Between
Military and Civilian Burn Patients
SO MILITARY MEDICINE
LA English
DT Article; Proceedings Paper
CT Military Health Systems Research Symposium (MHSRS)
CY AUG 13-16, 2012
CL Fort Lauderdale, FL
ID INHALATION INJURY; THERMAL-INJURY; MORTALITY; SCORE; PROBABILITY;
VICTIMS; DEATH; RISK; AGE
AB Background: The objective of this report was to compare the prevalence of acute respiratory distress syndrome (ARDS) and associated mortality between military service members with burns sustained during or in support of combat operations and civilian burn patients treated at a single burn center. Methods: Demographic and physiologic data were collected retrospectively on mechanically ventilated military and civilian patients admitted to our burn intensive care unit between January 2003 and December 2011. Patients with ARDS were identified and categorized as mild, moderate, or severe using the Berlin criteria. Demographics and clinical outcomes were compared. After initial comparison, propensity matching was performed and mortality compared. Results: A total of 891 burn patients required mechanical ventilation during the study period; 291 military and 600 civilian. The prevalence of ARDS was 34% (n = 304) for the entire cohort, 33% (n = 96) for military, and 35% (n = 208) for civilians (p = 0.55). For the entire cohort, despite more severe injury burden, military patients had a significantly lower overall mortality (17% vs. 28%; p = 0.0002) as well as ARDS mortality (33 vs. 48%, p = 0.02) when compared to civilians. This difference was not significant after propensity matching based on age. Conclusion: In a retrospective cohort study, burned military patients on mechanical ventilation had a significantly lower overall and ARDS mortality despite larger burns and more severe injury when compared to civilian burn patients. This difference appears to be largely because of age.
C1 [Waters, J. Alan; Lundy, Jonathan B.; Aden, James K.; Batchinsky, Andriy; Cancio, Leopoldo C.; Chung, Kevin K.] US Army Inst Surg Res, Ft Sam Houston, TX 78234 USA.
[Sine, Christy R.; Buel, Allison R.; Henderson, Jonathan L.; Stewart, Ian J.; Cannon, Jeremy W.] San Antonio Mil Med Ctr, Dept Med, Ft Sam Houston, TX 78234 USA.
[Chung, Kevin K.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA.
RP Waters, JA (reprint author), US Army Inst Surg Res, 3698 Chambers Pass Rd,Suite B, Ft Sam Houston, TX 78234 USA.
FU Clinical Trials for Burns and Trauma Task Area, U.S. Army Institute of
Surgical Research
FX K.K.C. contributed to the original conception of the study. S.M.B.,
A.R.B., C.R.S., I.J.S., and J.L.H. performed the data extraction and
management. J.K.A., J.A.W., and K.K.C. performed the data analysis and
created the charts and figures. J.A.W. and J. B. L. wrote the
manuscript. I.J.S., J.W.C., A.B., L.C.C. and K.K.C. critically reviewed
the manuscript. K.K.C. directed the study team and approved the final
manuscript. Funding for this study was provided by the Clinical Trials
for Burns and Trauma Task Area, U.S. Army Institute of Surgical
Research.
NR 17
TC 3
Z9 3
U1 0
U2 0
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
EI 1930-613X
J9 MIL MED
JI Milit. Med.
PD MAR
PY 2015
VL 180
IS 3
SU S
BP 56
EP 59
DI 10.7205/MILMED-D-14-00390
PG 4
WC Medicine, General & Internal
SC General & Internal Medicine
GA CD3OQ
UT WOS:000350988500013
PM 25747632
ER
PT J
AU Schauer, SG
Bellamy, MA
Mabry, RL
Bebarta, VS
AF Schauer, Steven G.
Bellamy, Michael A.
Mabry, Robert L.
Bebarta, Vikhyat S.
TI A Comparison of the Incidence of Cricothyrotomy in the Deployed Setting
to the Emergency Department at a Level 1 Military Trauma Center: A
Descriptive Analysis
SO MILITARY MEDICINE
LA English
DT Article; Proceedings Paper
CT Military Health Systems Research Symposium (MHSRS)
CY AUG 13-16, 2012
CL Fort Lauderdale, FL
ID SURGICAL CRICOTHYROIDOTOMY; MEDICINE RESIDENCY; AIRWAY MANAGEMENT;
INTUBATION; SUCCESS; SKILLS
AB Airway management is a critical skill of emergency medicine physicians and prehospital providers. Airway compromise is the cause of 1.8% of battlefield deaths. Cricothyrotomy is a critical, lifesaving procedure. In this study, we conducted a retrospective descriptive analysis comparing the incidence of cricothyrotomies in the deployed setting versus the incidence in a military level 1 trauma center emergency department (ED) setting in San Antonio, Texas. The deployed/in-theater procedures were performed from September 2007 to July 2009. The ED procedures were performed from April 2010 to February 2012. Over these study periods, 28 cricothyrotomies were performed in the deployed setting against a backdrop of 11,492 trauma admissions compared to 4 cricothyrotomies performed during 2,741 trauma admissions in the ED setting. The per admission incidence of deployed cricothyrotomies was 0.24% versus an incidence of 0.15% in the ED (p = 0.46). We conclude that this rare, lifesaving procedure is performed more often in the deployed setting than the ED, but this difference was not statistically significant.
C1 [Schauer, Steven G.] Bayne Jones Army Community Hosp, Ft Polk, LA 71459 USA.
[Bellamy, Michael A.] Martin Army Community Hosp, Ft Benning, GA 31905 USA.
[Mabry, Robert L.] San Antonio Mil Med Ctr, Ft Sam Houston, TX 78234 USA.
[Bebarta, Vikhyat S.] US Army Inst Surg Res, Ft Sam Houston, TX 78234 USA.
RP Schauer, SG (reprint author), Bayne Jones Army Community Hosp, 1585 3rd St, Ft Polk, LA 71459 USA.
RI bebarta, vikhyat/K-3476-2015
NR 20
TC 2
Z9 2
U1 0
U2 1
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
EI 1930-613X
J9 MIL MED
JI Milit. Med.
PD MAR
PY 2015
VL 180
IS 3
SU S
BP 60
EP 63
DI 10.7205/MILMED-D-14-00384
PG 4
WC Medicine, General & Internal
SC General & Internal Medicine
GA CD3OQ
UT WOS:000350988500014
PM 25747633
ER
PT J
AU Martini, WZ
Deguzman, R
Rodriguez, CM
Guerra, J
Martini, AK
Pusateri, AE
Dubick, MA
AF Martini, Wenjun Z.
Deguzman, Rodolfo
Rodriguez, Cassandra M.
Guerra, Jessica
Martini, Angela K.
Pusateri, Anthony E.
Dubick, Michael A.
TI Effect of Ibuprofen Dose on Platelet Aggregation and Coagulation in
Blood Samples From Pigs
SO MILITARY MEDICINE
LA English
DT Article; Proceedings Paper
CT Military Health Systems Research Symposium (MHSRS)
CY AUG 13-16, 2012
CL Fort Lauderdale, FL
ID LIVER-DISEASE; OVERDOSE; TRAUMA; PLASMA
AB Introduction: Ibuprofen is commonly used by Soldiers in the deployed environment. This study investigated its dose-effects on in vitro coagulation. Methods: Blood samples were collected from 4 normal healthy pigs and were processed to make platelet-adjusted (100 x 10(3)/mu L) blood samples. Ibuprofen was added to the samples at doses of 0 mu g/mL (control), recommended oral dose (163 mu g/mL, 1 x), 2 x, 4 x, 8 x, 10 x, 12 x, 16 x, and 20 x. Arachidonic acid or collagen-stimulated platelet aggregation was assessed at 15 minutes after the addition of ibuprofen. Coagulation was assessed with measurements of prothrombin time (PT) and activated partial thromboplastin time (aPTT), and thrombelastography by Rotem. Results: A robust inhibition of ibuprofen on arachidonic acid-induced platelet aggregation was observed at all doses tested. Collagen-stimulated platelet aggregation was inhibited to 71% +/- 5% and 10% +/- 5% of the control values at ibuprofen doses of 4 x and 20 x, respectively (both p < 0.05). No changes were observed in PT at any dose, but aPTT was prolonged at dose of 16 x and 20 x. Rotem measurements of coagulation time, clot formation time, maximum clot firmness, and A10 were compromised at dose 16 x and 20 x (all p < 0.05). Conclusion: Ibuprofen inhibited platelet aggregation at recommended doses, but did not compromise aPTT or coagulation profile until at 16 times the recommended doses and higher. Further effort is needed to clarify whether there are different dose-responses between human and pig blood samples in trauma situations.
C1 [Martini, Wenjun Z.; Deguzman, Rodolfo; Rodriguez, Cassandra M.; Guerra, Jessica; Dubick, Michael A.] US Army Inst Surg Res, Ft Sam Houston, TX 78234 USA.
[Martini, Angela K.] Rice Univ, Houston, TX 77251 USA.
[Pusateri, Anthony E.] US Army Med Res & Mat Command, Ft Detrick, MD 21702 USA.
RP Martini, WZ (reprint author), US Army Inst Surg Res, 3698 Chambers Pass, Ft Sam Houston, TX 78234 USA.
FU Laboratory Support Section at the U.S. Army Institute of Surgical
Research; U.S. Army Medical Research and Materiel Command
FX We appreciate the support received from the Laboratory Support Section
at the U.S. Army Institute of Surgical Research in coagulation
measurements. We thank Mr. John Jones for his assistance with
statistical analysis. This study was supported by the U.S. Army Medical
Research and Materiel Command.
NR 35
TC 1
Z9 1
U1 1
U2 2
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
EI 1930-613X
J9 MIL MED
JI Milit. Med.
PD MAR
PY 2015
VL 180
IS 3
SU S
BP 80
EP 85
DI 10.7205/MILMED-D-14-00395
PG 6
WC Medicine, General & Internal
SC General & Internal Medicine
GA CD3OQ
UT WOS:000350988500018
PM 25747637
ER
PT J
AU Dinos, ME
Borke, JL
Swiec, GD
McPherson, JC
Goodin, JL
Chuang, AH
AF Dinos, Michael E.
Borke, James L.
Swiec, Gary D.
McPherson, James C., III
Goodin, Jeremy L.
Chuang, Augustine H.
TI In Vitro Study of the Adverse Effect of Nicotine and Physical Strain on
Human Gingival Fibroblasts as a Model of the Healing of Wounds Commonly
Found in the Military
SO MILITARY MEDICINE
LA English
DT Article; Proceedings Paper
CT Military Health Systems Research Symposium (MHSRS)
CY AUG 13-16, 2012
CL Fort Lauderdale, FL
ID SMOOTH-MUSCLE-CELLS; TOBACCO PROMOTION; CYCLIC STRETCH; OSTEOBLASTS;
ATTACHMENT; EXPRESSION; SMOKING; INVITRO; MECHANOTRANSDUCTION; PERSONNEL
AB Background: Significant adverse effects on fibroblast growth and metabolism are observed with nicotine. We investigated the synergistic effects of nicotine and cyclical mechanical strain (CMS) on human gingival fibroblasts (HGFs) in a wound-healing model. Methods: HGFs were isolated and grown in Dulbecco's modified Eagle's medium. Three-millimeter wounds were created on a confluent cell monolayer grown in a media containing 0, 1, 2, or 4 mM nicotine, with or without CMS. The applied deformation regimen remains constant for 6 days. On days 1, 2, 4, and 6, the cells were stained with hematoxylin and eosin Y for the evaluation of wound repopulation. Results: The application of CMS alone demonstrates a biphasic response, with an initial stimulatory effect on wound repopulation (days 1-2) and less repopulation during the later phase (days 4-6). The addition of nicotine clearly demonstrated a time and inverse dose-dependent relationship on wound repopulation, with no effect during the early phase and reduced wound repopulation during the later phase. Conclusions: Initial treatment of HGF wounds with CMS resulted in faster wound repopulation regardless of nicotine presence. By day 6, wound healing of HGF exposed to both nicotine and CMS is delayed. These findings suggest that CMS and nicotine may affect fibroblasts and delay wound healing at other sites in the body as well.
C1 [Dinos, Michael E.; Swiec, Gary D.] Tingay Dent Clin, Ft Gordon, GA 30905 USA.
[McPherson, James C., III; Goodin, Jeremy L.; Chuang, Augustine H.] DD Eisenhower Army Med Ctr, Dept Clin Invest, Ft Gordon, GA 30905 USA.
[Borke, James L.] Western Univ Hlth Sci, Coll Dent Med, Pomona, CA 91766 USA.
RP Dinos, ME (reprint author), Tingay Dent Clin, 320 East Hosp Rd,Bldg 320, Ft Gordon, GA 30905 USA.
NR 37
TC 1
Z9 2
U1 2
U2 6
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
EI 1930-613X
J9 MIL MED
JI Milit. Med.
PD MAR
PY 2015
VL 180
IS 3
SU S
BP 86
EP 91
DI 10.7205/MILMED-D-14-00382
PG 6
WC Medicine, General & Internal
SC General & Internal Medicine
GA CD3OQ
UT WOS:000350988500019
PM 25747638
ER
PT J
AU Hwang, JI
Chuang, AH
Sidow, SJ
McNally, K
Goodin, JL
McPherson, JC
AF Hwang, Jae I.
Chuang, Augustine H.
Sidow, Stephanie J.
McNally, Kathleen
Goodin, Jeremy L.
McPherson, James C., III
TI The Effectiveness of Endodontic Solvents to Remove Endodontic Sealers
SO MILITARY MEDICINE
LA English
DT Article; Proceedings Paper
CT Military Health Systems Research Symposium (MHSRS)
CY AUG 13-16, 2012
CL Fort Lauderdale, FL
ID PROTAPER UNIVERSAL RETREATMENT; ROOT-CANAL RETREATMENT; GUTTA-PERCHA;
SETTING TIMES; EFFICACY; INSTRUMENTATION; CHLOROFORM; READINESS; ROTARY;
FILES
AB Dental emergencies negatively affect troop readiness, especially during combat. Endodontic retreatment, when required, is especially challenging when the removal of endodontic sealer is required. In this study, we investigated the effectiveness of synthetic endodontic solvents to remove endodontic sealers. Fifty capillary tubes (2.7 mm ID x 22 mm L), each filled to 15 mm with either Roth 801, AH Plus, MetaSEAL, or gutta-percha, were stored at 75% humidity for 14 days at 37 degrees C. Ten capillary tubes containing each sealer were treated with either chloroform, xylene, EndoSolv R, EndoSolv E, or no solvent, and then penetrated with D3 ProTaper Universal Retreatment file on the same day. The time for the file to penetrate the length of each sealer was recorded, and the data statistically analyzed. Roth 801 failed to set and was not tested. The file took 3.4 +/- 0.1, 4.8 +/- 0.3, 5.7 +/- 0.4, 4.5 +/- 0.2, and 10.6 +/- 1.0 seconds (mean +/- SD) to penetrate gutta-percha using chloroform, xylene, EndoSolv R, EndoSolv E, or no solvent, respectively, and was performed by one endodontic resident at one sitting. The time for penetration of gutta-percha with any solvent was significantly faster (p <= 0.05) than for AH Plus or MetaSEAL. The time for AH Plus ranged from 23.1 +/- 1.0 to 81.5 +/- 4.5 seconds. The time for MetaSEAL ranged from 97.2 +/- 6.1 to > 180 seconds. EndoSolv E was the most effective solvent for AH Plus. It took significantly more time to remove MetaSEAL than AH Plus, regardless of the solvent used. Our study indicated that the use of the proper endodontic solvent makes complete removal of a sealer much more effective during retreatment.
C1 [Hwang, Jae I.; Sidow, Stephanie J.; McNally, Kathleen] Tingay Army Dent Clin, Ft Gordon, GA 30905 USA.
[Chuang, Augustine H.; Goodin, Jeremy L.; McPherson, James C., III] DD Eisenhower Army Med Ctr, Dept Clin Invest, Ft Gordon, GA 30905 USA.
RP Hwang, JI (reprint author), Tingay Army Dent Clin, 320 East Hosp Rd,Bldg 320, Ft Gordon, GA 30905 USA.
NR 25
TC 0
Z9 0
U1 1
U2 5
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
EI 1930-613X
J9 MIL MED
JI Milit. Med.
PD MAR
PY 2015
VL 180
IS 3
SU S
BP 92
EP 95
DI 10.7205/MILMED-D-14-00379
PG 4
WC Medicine, General & Internal
SC General & Internal Medicine
GA CD3OQ
UT WOS:000350988500020
PM 25747639
ER
PT J
AU Lattimore, MR
AF Lattimore, Morris R.
TI Brief Report: A Hypothetical Construct Based on Limited Data Visual
System Recovery After Refractive Surgery
SO MILITARY MEDICINE
LA English
DT Article; Proceedings Paper
CT Military Health Systems Research Symposium (MHSRS)
CY AUG 13-16, 2012
CL Fort Lauderdale, FL
ID PLASTICITY
AB Laser refractive surgery, involving the computer-controlled application of a 193-nm beam of excimer laser "light," is utilized to resculpt the central cornea, thus reducing its apical thickness. On casual inspection, this simple matter of removing or excising a specific amount of central corneal avascular tissue is a smooth, seamless alteration with few apparent secondary issues or sequelae. Normal postoperative recovery is typically gauged by the recovery of high-contrast visual acuity to the same (or better) degree as was previously obtained with a spectacle correction. However, although this is an acceptable means of determining operative success, it is not indicative of the complex challenges imposed upon the neurosensory system. The secondarily imposed strain upon the visual system, regarding the return to its pre-existing visual line-of-sight organization occurs only by bringing multiple adaptations into subtle and seamless play. This process is initiated and completed in a relatively short time period, such that most patients (but not all) are not even marginally aware of the challenges imposed to the visual system. This article is meant to probe those system challenges, serving to highlight this postoperative plasticity, seeking to gain a broader understanding and appreciation of the perceptual range of the visual recovery process.
C1 US Army Aeromed Res Lab, Ft Rucker, AL 36362 USA.
RP Lattimore, MR (reprint author), US Army Aeromed Res Lab, 6901 Farrell Rd, Ft Rucker, AL 36362 USA.
FU Naval Refractive Surgery Research Program at the Naval Regional Medical
Center-San Diego (NRMC-SD)
FX A special thank you is submitted to the Balboa Medical Center clinical
and scientific staff, and to the Navy Health Research Laboratory
research staff. Their gracious voluntary acceptance of my presence into
their fold was an unexpected additional benefit to my Joint Research
assignment. Data were gathered under the fiscal auspices of the Naval
Refractive Surgery Research Program at the Naval Regional Medical
Center-San Diego (NRMC-SD); this analytical report stems from a Medical
Research and Materiel Command-Intra-Laboratory In-house Research
(MRMC-ILIR) award to the U.S. Army Aeromedical Research Laboratory
(USAARL).
NR 19
TC 0
Z9 0
U1 0
U2 2
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
EI 1930-613X
J9 MIL MED
JI Milit. Med.
PD MAR
PY 2015
VL 180
IS 3
SU S
BP 187
EP 190
DI 10.7205/MILMED-D-14-00409
PG 4
WC Medicine, General & Internal
SC General & Internal Medicine
GA CD3OQ
UT WOS:000350988500032
PM 25747651
ER
PT J
AU Bowles, SV
Pollock, LD
Moore, M
Wadsworth, SM
Cato, C
Dekle, JW
Meyer, SW
Shriver, A
Mueller, B
Stephens, M
Seidler, DA
Sheldon, J
Picano, J
Finch, W
Morales, R
Blochberger, S
Kleiman, ME
Thompson, D
Bates, MJ
AF Bowles, Stephen V.
Pollock, Liz Davenport
Moore, Monique
Wadsworth, Shelley MacDermid
Cato, Colanda
Dekle, Judith Ward
Meyer, Sonia Wei
Shriver, Amber
Mueller, Bill
Stephens, Mark
Seidler, Dustin A.
Sheldon, Joseph
Picano, James
Finch, Wanda
Morales, Ricardo
Blochberger, Sean
Kleiman, Matthew E.
Thompson, Daniel
Bates, Mark J.
TI Total Force Fitness: The Military Family Fitness Model
SO MILITARY MEDICINE
LA English
DT Article
ID POSTTRAUMATIC STRESS SYMPTOMS; OPERATION DESERT-STORM; RELATIONSHIP
SATISFACTION; EMOTIONAL INTELLIGENCE; CIRCUMPLEX MODEL; SERVICE MEMBERS;
PTSD SYMPTOMS; MENTAL-HEALTH; WORK-FAMILY; RESILIENCE
AB The military lifestyle can create formidable challenges for military families. This article describes the Military Family Fitness Model (MFFM), a comprehensive model aimed at enhancing family fitness and resilience across the life span. This model is intended for use by Service members, their families, leaders, and health care providers but also has broader applications for all families. The MFFM has three core components: (1) family demands, (2) resources (including individual resources, family resources, and external resources), and (3) family outcomes (including related metrics). The MFFM proposes that resources from the individual, family, and external areas promote fitness, bolster resilience, and foster well-being for the family. The MFFM highlights each resource level for the purpose of improving family fitness and resilience over time. The MFFM both builds on existing family strengths and encourages the development of new family strengths through resource-acquiring behaviors. The purpose of this article is to (1) expand the military's Total Force Fitness (TFF) intent as it relates to families and (2) offer a family fitness model. This article will summarize relevant evidence, provide supportive theory, describe the model, and proffer metrics that support the dimensions of this model.
C1 [Bowles, Stephen V.; Blochberger, Sean] Natl Def Univ, Eisenhower Sch, Washington, DC 20319 USA.
[Pollock, Liz Davenport] Uniformed Serv Univ Hlth Sci, Dept Mil & Emergency Med, Human Performance Resource Ctr, Bethesda, MD 20814 USA.
[Moore, Monique; Cato, Colanda; Finch, Wanda; Bates, Mark J.] Def Ctr Excellence Psychol Hlth, Silver Spring, MD 20910 USA.
[Moore, Monique; Cato, Colanda; Finch, Wanda; Bates, Mark J.] Def Ctr Traumat Brain Injury, Silver Spring, MD 20910 USA.
[Wadsworth, Shelley MacDermid] Purdue Univ, Mil Family Res Inst, W Lafayette, IN 47907 USA.
[Dekle, Judith Ward] Dept Def Mil & Community Family Policy, Washington, DC 20301 USA.
[Meyer, Sonia Wei] Beijing Univ Aeronaut & Astronaut, Beijing 100083, Peoples R China.
[Shriver, Amber] George Mason Univ, Dept Psychol, Fairfax, VA 22030 USA.
[Mueller, Bill] Human Syst Integrat Directorate, Wright Patterson AFB, OH 45433 USA.
[Stephens, Mark] Uniformed Serv Univ Hlth Sci, Dept Family Med, Bethesda, MD 20814 USA.
[Seidler, Dustin A.] So Illinois Univ, Dept Psychol, Carbondale, IL 62901 USA.
[Sheldon, Joseph] Off Religious Affairs J1, Washington, DC 20318 USA.
[Picano, James] Northern Calif Hlth Care Syst, Dept Vet Affairs, Martinez, CA 94553 USA.
[Morales, Ricardo] US Army Cadet Command, San Antonio, TX 78204 USA.
[Kleiman, Matthew E.] US Coast Guard, Behav Hlth Serv Div, Washington, DC 20593 USA.
[Thompson, Daniel] Warrior Transit Unit, Ft Bragg, NC 28310 USA.
RP Bowles, SV (reprint author), Natl Def Univ, Eisenhower Sch, 408 4th Ave, Washington, DC 20319 USA.
NR 114
TC 2
Z9 2
U1 5
U2 9
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
EI 1930-613X
J9 MIL MED
JI Milit. Med.
PD MAR
PY 2015
VL 180
IS 3
BP 246
EP 258
DI 10.7205/MILMED-D-13-00416
PG 13
WC Medicine, General & Internal
SC General & Internal Medicine
GA CD3OI
UT WOS:000350987700008
PM 25735013
ER
PT J
AU Roy, TC
Piva, SR
Christiansen, BC
Lesher, JD
Doyle, PM
Waring, RM
Irrgang, JJ
Moore, CG
Brininger, TL
Sharp, MA
AF Roy, Tanja C.
Piva, Sara R.
Christiansen, Bryan C.
Lesher, Jonathan D.
Doyle, Peter M.
Waring, Rachel M.
Irrgang, James J.
Moore, Charity G.
Brininger, Teresa L.
Sharp, Marilyn A.
TI Description of Musculoskeletal Injuries Occurring in Female Soldiers
Deployed to Afghanistan
SO MILITARY MEDICINE
LA English
DT Article
ID LOW-BACK-PAIN; OPERATION IRAQI FREEDOM; BRIGADE COMBAT TEAM;
TRAINING-RELATED INJURIES; RISK-FACTORS; ENDURING FREEDOM; US ARMY;
PHYSICAL THERAPIST; PROSPECTIVE COHORT; OUTPATIENT VISITS
AB Each year musculoskeletal injuries (MSIs) result in thousands of lost duty days and medical discharges. Women represent 15% of the Army and have higher incidence of injury than male soldiers; studies that have investigated MSIs in deployed women are lacking. Therefore, the purpose of this prospective cohort study was to investigate MSIs in women during a 9-month deployment to Afghanistan. Participants were recruited from three Brigade Combat Teams. Participants completed a demographic survey before deployment and a second survey on occupational demands and MSIs after deployment. Of the 160 women, 57 (36%) suffered 78 MSIs resulting in 1,642 days of limited duty, a median of 7 days per MSI, losing 10% of the available duty time to MSIs. Most injuries affected the knee (24%) or low back (18%). Soldiers attributed the majority of injuries (27%) to physical training and trips/falls (17%). Of the MSIs, 93% caused limitations to physical training and 76% resulted in large limitations to occupational tasks. Most MSIs (41%) resolved within 3 weeks and most (37%) occurred before the fourth month of deployment. Prevention measures should target knee and low back injuries. Physical training should be further investigated to discover modifications capable of reducing injuries.
C1 [Roy, Tanja C.; Piva, Sara R.; Irrgang, James J.] Univ Pittsburgh, Sch Hlth & Rehabil Sci, Pittsburgh, PA 15260 USA.
[Christiansen, Bryan C.] 101st Airborne Div, Airborne Brigade Combat Team 1, Campbell, KY 42223 USA.
[Lesher, Jonathan D.; Doyle, Peter M.] 173rd Airborne Brigade Combat Team, APO, AE 09630 USA.
[Waring, Rachel M.] 10th Mt Div, Brigade Combat Team 2, Ft Drum, NY 13602 USA.
[Moore, Charity G.] Univ Pittsburgh, Ctr Res Hlth Care, Ctr Data, Dept Med,Sch Med, Pittsburgh, PA 15213 USA.
[Brininger, Teresa L.] Med Res & Mat Command, Ft Detrick, MD 21702 USA.
[Sharp, Marilyn A.] US Army Res Inst Environm Med, Natick, MA 01760 USA.
RP Roy, TC (reprint author), Univ Pittsburgh, Sch Hlth & Rehabil Sci, 4028 Forbes Tower, Pittsburgh, PA 15260 USA.
FU U.S. Army Medical Research and Materiel Command under Task Area S
FX We thank the soldiers from the 173rd Airborne Brigade Combat Team
(ABCT); the 1st ABCT, 101st Airborne Division; and the 2nd BCT, 10th
Mountain Light Infantry Division for all of their assistance in making
this study possible. This research was funded by U.S. Army Medical
Research and Materiel Command under Task Area S.
NR 53
TC 2
Z9 2
U1 1
U2 4
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
EI 1930-613X
J9 MIL MED
JI Milit. Med.
PD MAR
PY 2015
VL 180
IS 3
BP 269
EP 275
DI 10.7205/MILMED-D-14-00365
PG 7
WC Medicine, General & Internal
SC General & Internal Medicine
GA CD3OI
UT WOS:000350987700011
PM 25735016
ER
PT J
AU Weidlich, CP
Ugarriza, DN
AF Weidlich, Christopher P.
Ugarriza, Doris N.
TI A Pilot Study Examining the Impact of Care Provider Support Program on
Resiliency, Coping, and Compassion Fatigue in Military Health Care
Providers
SO MILITARY MEDICINE
LA English
DT Article
ID POSTTRAUMATIC-STRESS-DISORDER; WORK; AFGHANISTAN; DEPRESSION;
DEPLOYMENT; VETERANS; IRAQ
AB Objectives: The Care Provider Support Program (CPSP) was created as a way to improve the resiliency of military health care providers. The purpose of this pilot study was to update what is currently known about the resiliency, coping, and compassion fatigue of military and civilian registered nurses, licensed practical nurses (LPNs), and medics who treat wounded Soldiers and whether these factors can be improved over a sustained period of time. Methods: A prospective cohort pilot study was implemented to investigate the long-term effects of CPSP training on military and civilian nurses, LPNs, and medics (n = 93) at an Army Medical Center utilizing the Connor-Davidson Resilience Scale, the Ways of Coping Questionnaire, and Professional Quality of Life Questionnaire. Twenty-eight participants returned follow-up questionnaires. Results: CPSP was significant in reducing burnout as measured by the Professional Quality of Life questionnaire, leading to decreased compassion fatigue. CPSP training did not affect resiliency scores on the Connor-Davidson resilience scale or coping scores as measured by the Ways of Coping Questionnaire. Conclusions: on the basis of the results of this study, CPSP training was effective in reducing burnout, which often leads to decreased compassion fatigue in a group of military and civilian registered nurses, LPNs, and medics.
C1 [Weidlich, Christopher P.] Joint Base San Antonio, Ctr Nursing Sci & Clin Inquiry, Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA.
[Ugarriza, Doris N.] Univ Miami, Sch Nursing & Hlth Studies, Coral Gables, FL 33126 USA.
RP Weidlich, CP (reprint author), Joint Base San Antonio, Ctr Nursing Sci & Clin Inquiry, Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA.
FU TriService Nursing Research Program (TSNRP) [HT9404-12-1-TS17]
FX We thank Dr. Doris Ugarriza, Dr. Daniel Santisteban, Dr. Karina
Gattamorta, Dr. Leigh McGraw, and Ms. Marlene Martin who contributed to
this study. Additionally, we thank the TriService Nursing Research
Program (TSNRP) for funding this study. TriService Nursing Research
Program (TSNRP) grant (HT9404-12-1-TS17) was awarded to the funding of
the study.
NR 29
TC 3
Z9 3
U1 5
U2 16
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
EI 1930-613X
J9 MIL MED
JI Milit. Med.
PD MAR
PY 2015
VL 180
IS 3
BP 290
EP 295
DI 10.7205/MILMED-D-14-00216
PG 6
WC Medicine, General & Internal
SC General & Internal Medicine
GA CD3OI
UT WOS:000350987700014
PM 25735019
ER
PT J
AU Shackelford, SA
Fowler, M
Schultz, K
Summers, A
Galvagno, SM
Gross, KR
Mabry, RL
Bailey, JA
Kotwal, RS
Butler, FK
AF Shackelford, Stacy A.
Fowler, Marcie
Schultz, Keith
Summers, Angela
Galvagno, Samuel M.
Gross, Kirby R.
Mabry, Robert L.
Bailey, Jeffrey A.
Kotwal, Russ S.
Butler, Frank K.
TI Prehospital Pain Medication Use by U.S. Forces in Afghanistan
SO MILITARY MEDICINE
LA English
DT Article
ID COMBAT CASUALTY CARE; POSTTRAUMATIC-STRESS-DISORDER; KETAMINE;
MANAGEMENT; TRAUMA; BATTLEFIELD; EXPERIENCE; OPERATIONS; FENTANYL;
EFFICACY
AB We report the results of a process improvement initiative to examine the current use and safety of prehospital pain medications by U.S. Forces in Afghanistan. Prehospital pain medication data were prospectively collected on 309 casualties evacuated from point of injury (POI) to surgical hospitals from October 2012 to March 2013. Vital signs obtained from POI and flight medics and on arrival to surgical hospitals were compared using one-way analysis of variance test. 119 casualties (39%) received pain medication during POI care and 283 (92%) received pain medication during tactical evacuation (TACEVAC). Morphine and oral transmucosal fentanyl citrate were the most commonly used pain medications during POI care, whereas ketamine and fentanyl predominated during TACEVAC. Ketamine was associated with increase in systolic blood pressure compared to morphine (+7 +/- 17 versus -3 +/- 14 mm Hg, p = 0.04). There was no difference in vital signs on arrival to the hospital between casualties who received no pain medication, morphine, fentanyl, or ketamine during TACEVAC. In this convenience sample, fentanyl and ketamine were as safe as morphine for prehospital use within the dose ranges administered. Future efforts to improve battlefield pain control should focus on improved delivery of pain control at POI and the role of combination therapies.
C1 [Shackelford, Stacy A.] Univ Maryland, Med Ctr, Ctr Sustainment Trauma & Readiness Skills, R Adams Cowley Shock Trauma Ctr, Baltimore, MD 21201 USA.
[Fowler, Marcie; Gross, Kirby R.; Mabry, Robert L.; Bailey, Jeffrey A.; Kotwal, Russ S.; Butler, Frank K.] US Army Inst Surg Res, Joint Trauma Syst, Ft Sam Houston, TX 78234 USA.
[Schultz, Keith] 81 Med Operat Squadron, Keesler AFB, MS 39534 USA.
[Summers, Angela] 212 Combat Support Hosp, Miesau Ad, Germany.
[Galvagno, Samuel M.] Univ Maryland, Med Ctr, Dept Anesthesiol, Baltimore, MD 21201 USA.
RP Shackelford, SA (reprint author), Univ Maryland, Med Ctr, Ctr Sustainment Trauma & Readiness Skills, R Adams Cowley Shock Trauma Ctr, 22 S Greene St, Baltimore, MD 21201 USA.
NR 30
TC 2
Z9 2
U1 4
U2 6
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
EI 1930-613X
J9 MIL MED
JI Milit. Med.
PD MAR
PY 2015
VL 180
IS 3
BP 304
EP 309
DI 10.7205/MILMED-D-14-00257
PG 6
WC Medicine, General & Internal
SC General & Internal Medicine
GA CD3OI
UT WOS:000350987700016
PM 25735021
ER
PT J
AU Noe, A
AF Noe, Adrianne
TI The Material Culture of Military Medicine
SO MILITARY MEDICINE
LA English
DT Editorial Material
C1 US Army Med Res & Materiel Command, Natl Museum Hlth & Med, Silver Spring, MD 20910 USA.
RP Noe, A (reprint author), US Army Med Res & Materiel Command, Natl Museum Hlth & Med, 2500 Linden Lane, Silver Spring, MD 20910 USA.
NR 2
TC 0
Z9 0
U1 1
U2 2
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
EI 1930-613X
J9 MIL MED
JI Milit. Med.
PD MAR
PY 2015
VL 180
IS 3
BP 361
EP 362
DI 10.7205/MILMED-D-14-00549
PG 2
WC Medicine, General & Internal
SC General & Internal Medicine
GA CD3OI
UT WOS:000350987700025
PM 25735030
ER
PT J
AU Dumayas, GL
Capo-Aponte, JE
AF Dumayas, Grace Lea
Capo-Aponte, Jose E.
TI Case Report: Waardenburg Syndrome
SO MILITARY MEDICINE
LA English
DT Article
ID SYNDROME TYPE-I; SYNDROME TYPE-2; GENE; DEFINITION; MUTATIONS;
ANOMALIES; DIAGNOSIS; DELETIONS; CRITERIA
AB Purpose: A case of Waardenburg syndrome type 1 is described and relevant literature is reviewed to raise awareness about this rare syndrome, including the classification of each subtype and the differentiating clinical manifestations. Case Report: A 44-year-old African-American female presented for a routine evaluation with hearing loss, dystopia canthorum (W index = 2.74), and almost complete gray hair. In addition, she presented with heterochromia irides, different fundus pigmentation between eyes. The patient did not have any upper limbs defect, cranial skeletal abnormalities, or intestinal disorders. Conclusion: Facial abnormalities and a white forelock are prominent features difficult to overlook during a routine ophthalmological examination. A careful medical history in patients with suspected Waardenburg syndrome is important to accurately classify this rare condition and to identify potential systemic implications associated to each subtype. The associated systemic complications can be addressed and managed through referral to the appropriate subspecialties.
C1 [Dumayas, Grace Lea] Northeastern State Univ Oklahoma, Coll Optometry, Tahlequah, OK 74464 USA.
[Capo-Aponte, Jose E.] Womack Army Med Ctr, Dept Optometry, Ft Bragg, NC 28310 USA.
RP Dumayas, GL (reprint author), Northeastern State Univ Oklahoma, Coll Optometry, 1001 North Grand Ave, Tahlequah, OK 74464 USA.
NR 39
TC 0
Z9 0
U1 1
U2 5
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
EI 1930-613X
J9 MIL MED
JI Milit. Med.
PD MAR
PY 2015
VL 180
IS 3
BP E381
EP E387
DI 10.7205/MILMED-D-14-00430
PG 7
WC Medicine, General & Internal
SC General & Internal Medicine
GA CD3OI
UT WOS:000350987700006
PM 25735036
ER
PT J
AU Plackett, TP
Naeem, M
AF Plackett, Timothy P.
Naeem, Mohammad
TI Percutaneous CT-Guided Drainage of a Postoperative Intra-Abdominal
Abscess in a Combat Environment
SO MILITARY MEDICINE
LA English
DT Article
ID DEEP PELVIC ABSCESSES; IN-VITRO; CATHETERS
AB Combat medical care results in limited resource availability, which can prompt creativity in treatment of otherwise common conditions. A postoperative intra-abdominal abscess is not an uncommon occurrence following traumatic hollow viscous injury in the deployed environment, but treatment is often limited to surgical drainage only. Herein, we describe a novel use of a dual-lumen central venous catheter to obtain percutaneous drainage of a postoperative intra-abdominal abscess.
C1 [Plackett, Timothy P.] Womack Army Med Ctr, Dept Surg, Ft Bragg, NC 28307 USA.
[Naeem, Mohammad] Landstuhl Reg Med Ctr, Dept Radiol, D-66849 Landstuhl, Germany.
RP Plackett, TP (reprint author), Womack Army Med Ctr, Dept Surg, 2817 Reilly Rd, Ft Bragg, NC 28307 USA.
NR 9
TC 0
Z9 0
U1 0
U2 0
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
EI 1930-613X
J9 MIL MED
JI Milit. Med.
PD MAR
PY 2015
VL 180
IS 3
BP E375
EP E377
DI 10.7205/MILMED-D-14-00423
PG 3
WC Medicine, General & Internal
SC General & Internal Medicine
GA CD3OI
UT WOS:000350987700004
PM 25735034
ER
PT J
AU Gillespie, WT
AF Gillespie, William T., Jr.
TI The Green and the Gray: The Irish in the Confederate States of America
SO REVIEWS IN AMERICAN HISTORY
LA English
DT Book Review
C1 [Gillespie, William T., Jr.] US Mil Acad, West Point, NY USA.
RP Gillespie, WT (reprint author), Armstrong Atlantic State Univ, Mil Hist World Civilizat & Geog Courses, Savannah, GA 31419 USA.
NR 4
TC 0
Z9 0
U1 0
U2 0
PU JOHNS HOPKINS UNIV PRESS
PI BALTIMORE
PA JOURNALS PUBLISHING DIVISION, 2715 NORTH CHARLES ST, BALTIMORE, MD
21218-4363 USA
SN 0048-7511
EI 1080-6628
J9 REV AM HIST
JI Rev. Am. Hist.
PD MAR
PY 2015
VL 43
IS 1
BP 70
EP 76
PG 7
WC History
SC History
GA CD8EH
UT WOS:000351327500015
ER
PT J
AU Rossi, CA
Kearney, BJ
Olschner, SP
Williams, PL
Robinson, CG
Heinrich, ML
Zovanyi, AM
Ingram, MF
Norwood, DA
Schoepp, RJ
AF Rossi, Cynthia A.
Kearney, Brian J.
Olschner, Scott P.
Williams, Priscilla L.
Robinson, Camenzind G.
Heinrich, Megan L.
Zovanyi, Ashley M.
Ingram, Michael F.
Norwood, David A.
Schoepp, Randal J.
TI Evaluation of ViroCyt((R)) Virus Counter for Rapid Filovirus
Quantitation
SO VIRUSES-BASEL
LA English
DT Article
ID TRANSMISSION ELECTRON-MICROSCOPY; EBOLA-VIRUS; QUANTIFICATION;
ENUMERATION; INFECTION; DESIGN; ASSAYS
AB Development and evaluation of medical countermeasures for diagnostics, vaccines, and therapeutics requires production of standardized, reproducible, and well characterized virus preparations. For filoviruses this includes plaque assay for quantitation of infectious virus, transmission electron microscopy (TEM) for morphology and quantitation of virus particles, and real-time reverse transcription PCR for quantitation of viral RNA (qRT-PCR). The ViroCyt((R)) Virus Counter (VC) 2100 (ViroCyt, Boulder, CO, USA) is a flow-based instrument capable of quantifying virus particles in solution. Using a proprietary combination of fluorescent dyes that stain both nucleic acid and protein in a single 30 min step, rapid, reproducible, and cost-effective quantification of filovirus particles was demonstrated. Using a seed stock of Ebola virus variant Kikwit, the linear range of the instrument was determined to be 2.8E+06 to 1.0E+09 virus particles per mL with coefficient of variation ranging from 9.4% to 31.5% for samples tested in triplicate. VC particle counts for various filovirus stocks were within one log of TEM particle counts. A linear relationship was established between the plaque assay, qRT-PCR, and the VC. VC results significantly correlated with both plaque assay and qRT-PCR. These results demonstrated that the VC is an easy, fast, and consistent method to quantify filoviruses in stock preparations.
C1 [Rossi, Cynthia A.; Kearney, Brian J.; Olschner, Scott P.; Williams, Priscilla L.; Heinrich, Megan L.; Zovanyi, Ashley M.; Ingram, Michael F.; Norwood, David A.; Schoepp, Randal J.] US Army Med Res Inst Infect Dis, Diagnost Syst Div, Ft Detrick, MD 21702 USA.
[Robinson, Camenzind G.] US Army Med Res Inst Infect Dis, Div Pathol, Ft Detrick, MD 21702 USA.
RP Rossi, CA (reprint author), US Army Med Res Inst Infect Dis, Diagnost Syst Div, Ft Detrick, MD 21702 USA.
EM cynthia.a.rossi.civ@mail.mil; brian.j.kearney.civ@mail.mil;
scott.p.olschner.civ@mail.mil; priscilla.l.williams4.ctr@mail.mil;
robinsonc@janelia.hhmi.org; mheinrich7295@gmail.com; azovanyi@gmail.com;
michael.f.ingram.mil@mail.mil; david.a.norwood.civ@mail.mil;
randal.j.schoepp.civ@mail.mil
FU Joint Executive Office; Critical Reagents Program; Medical
Countermeasure Systems-Joint Vaccine Acquisition Program [1143605]
FX This study was supported by the Joint Executive Office, Critical
Reagents Program and Medical Countermeasure Systems-Joint Vaccine
Acquisition Program (1143605).
NR 22
TC 8
Z9 8
U1 1
U2 2
PU MDPI AG
PI BASEL
PA POSTFACH, CH-4005 BASEL, SWITZERLAND
SN 1999-4915
J9 VIRUSES-BASEL
JI Viruses-Basel
PD MAR
PY 2015
VL 7
IS 3
BP 857
EP 872
DI 10.3390/v7030857
PG 16
WC Virology
SC Virology
GA CE6JP
UT WOS:000351943000001
PM 25710889
ER
PT J
AU Bebarta, VS
Garrett, N
Boudreau, S
Castaneda, M
AF Bebarta, Vikhyat S.
Garrett, Normalynn
Boudreau, Susan
Castaneda, Maria
TI A Prospective, Randomized Trial of Intravenous Hydroxocobalamin Versus
Whole Blood Transfusion Compared to No Treatment for Class III
Hemorrhagic Shock Resuscitation in a Prehospital Swine Model
SO ACADEMIC EMERGENCY MEDICINE
LA English
DT Article
ID TRAUMA-ASSOCIATED COAGULOPATHY; PLACEBO-CONTROLLED MULTICENTER; ARGININE
HYDROCHLORIDE 546C88; ACUTE CYANIDE TOXICITY; SUS-SCROFA MODEL;
NITRIC-OXIDE; FLUID RESUSCITATION; UNCONTROLLED HEMORRHAGE;
DOUBLE-BLIND; SODIUM THIOSULFATE
AB ObjectivesThe objective was to compare systolic blood pressure (sBP) over time in swine that have had 30% of their blood volume removed (Class III shock) and treated with intravenous (IV) whole blood or IV hydroxocobalamin, compared to nontreated control animals.
MethodsThirty swine (45 to 55kg) were anesthetized, intubated, and instrumented with continuous femoral and pulmonary artery pressure monitoring. Animals were hemorrhaged a total of 20 mL/kg over a 20-minute period. Five minutes after hemorrhage, animals were randomly assigned to receive 150 mg/kg IV hydroxocobalamin solubilized in 180 mL of saline, 500 mL of whole blood, or no treatment. Animals were monitored for 60 minutes thereafter. A sample size of 10 animals per group was determined based on a power of 80% and an alpha of 0.05 to detect an effect size of at least a 0.25 difference (>1 standard deviation) in mean sBP between groups. sBP values were analyzed using repeated-measures analysis of variance (RANOVA). Secondary outcome data were analyzed using repeated-measures multivariate analysis of variance (RMANOVA).
ResultsThere were no significant differences between hemodynamic parameters of IV hydroxocobalamin versus whole blood versus control group at baseline (MANOVA; Wilks' lambda; p=0.868) or immediately posthemorrhage (mean sBP= 47mm Hg vs. 41mm Hg vs. 37mm Hg; mean arterial pressure= 39mm Hg vs. 28mm Hg vs. 34mm Hg; mean serum lactate= 1.2mmol/L vs. 1.4mmol/L vs. 1.4mmol/L; MANOVA; Wilks' lambda; p=0.348). The outcome RANOVA model detected a significant difference by time between groups (p<0.001). Specifically, 10minutes after treatment, treated animals showed a significant increase in mean sBP compared to nontreated animals (mean sBP= 76.3mm Hg vs. 85.7mm Hg vs. 51.1mm Hg; p<0.001). RMANOVA modeling of the secondary data detected a significant difference in mean arterial pressure, heart rate, and serum lactate (p<0.001). Similar to sBP, 10minutes after treatment, treated animals showed a significant increase in mean arterial pressure compared to nontreated animals (mean arterial pressure= 67.7mm Hg vs. 61.4mm Hg vs. 40.5mm Hg). By 10minutes, mean heart rate was significantly slower in treated animals compared to nontreated animals (mean heart rate= 97.3 beats/min vs. 95.2 beats/min vs. 129.5 beats/min; p<0.05). Serum lactate, an early predictor of shock, continued to rise in the control group, whereas it did not in treated animals. Thirty minutes after treatment, serum lactate values of treated animals were significantly lower compared to nontreated animals (p<0.05). This trend continued throughout the 60-minute observation period such that 60-minute values for lactate were 1.4mmol/L versus 1.1mmol/L versus 3.8mmol/L. IV hydroxocobalamin produced a statistically significant increase in systemic vascular resistance compared to control, but not whole blood, with a concomitant decrease in cardiac output.
ConclusionsIntravenous hydroxocobalamin was more effective than no treatment and as effective as whole blood transfusion, in reversing hypotension and inhibiting rises in serum lactate in this prehospital, controlled, Class III swine hemorrhage model. (C) 2015 by the Society for Academic Emergency Medicine
C1 [Bebarta, Vikhyat S.; Garrett, Normalynn; Boudreau, Susan; Castaneda, Maria] San Antonio Mil Med Ctr, CREST Res Program, Dept Emergency Med, San Antonio, TX 78234 USA.
[Bebarta, Vikhyat S.] US Army, Enroute Care Res Ctr, Inst Surg Res, San Antonio, TX USA.
RP Bebarta, VS (reprint author), San Antonio Mil Med Ctr, CREST Res Program, Dept Emergency Med, San Antonio, TX 78234 USA.
EM vikbebarta@yahoo.com
RI bebarta, vikhyat/K-3476-2015
FU U.S. Air Force Office of the Surgeon General
FX The U.S. Air Force Office of the Surgeon General funded this study. No
other funding was used. The views expressed in this article are those of
the authors and do not reflect the official policy or position of the
Department of the U.S. Air Force, Department of Defense, or the U.S.
government. The author have no potential conflicts of interest to
report.
NR 70
TC 0
Z9 0
U1 0
U2 3
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1069-6563
EI 1553-2712
J9 ACAD EMERG MED
JI Acad. Emerg. Med.
PD MAR
PY 2015
VL 22
IS 3
SI SI
BP 321
EP 330
DI 10.1111/acem.12605
PG 10
WC Emergency Medicine
SC Emergency Medicine
GA CD3MA
UT WOS:000350981500009
PM 25731610
ER
PT J
AU Gunay, F
Alten, B
Simsek, F
Aldemir, A
Linton, YM
AF Gunay, Filiz
Alten, Bulent
Simsek, Fatih
Aldemir, Adnan
Linton, Yvonne-Marie
TI Barcoding Turkish Culex mosquitoes to facilitate arbovirus vector
incrimination studies reveals hidden diversity and new potential vectors
SO ACTA TROPICA
LA English
DT Article
DE DNA barcoding; Culex; Arbovirus; Vector; New records; Turkey
ID WEST-NILE-VIRUS; ST-LOUIS ENCEPHALITIS; DIPTERA-CULICIDAE; JAPANESE
ENCEPHALITIS; VERTICAL TRANSMISSION; MODESTUS FICALBI; SINDBIS VIRUS;
GETAH VIRUS; TURKEY; CIRCULATION
AB As a precursor to planned arboviral vector incrimination studies, an integrated systematics approach was adopted using morphology and DNA barcoding to examine the Culex fauna present in Turkey. The mitochondrial COI gene (658 bp) were sequenced from 185 specimens collected across 11 Turkish provinces, as well as from colony material.
Although by morphology only 9 species were recognised, DNA barcoding recovered 13 distinct species including: Cx. (Barraudius) modestus, Cx. (Culex) laticinctus, Cx. (Cux.) mimeticus, Cx. (Cux.) perexiguus, Cx. (Cux.) pipiens, Cx. (Cux.) pipiens form molestus, Cx. (Cux.) quinquefasciatus, Cx. (Cux.) theilen, Cx. (Cux.) torrentium, Cx. (Cux.) tritaeniorhynchus and Cx. (Maillotia) hortensis. The taxon formerly identified as Cx. (Neoculex) territans was shown to comprise two distinct species, neither of which correspond to Cx. territans s.s. These include Cx. (Neo.) impudicus and another uncertain species, which may be Cx. (Neo.) europaeus or Cx. (Neo.) martinii (herein =Cx. (Neo.) sp. 1). Detailed examination of the Pipiens Group revealed Cx. pipiens, Cx. pipiens f. molestus and the widespread presence of the highly efficient West Nile virus vector Cx. quinquefasciatus for the first time. Four new country records are reported, increasing the Culex of Turkey to 15 recognised species and Cx. pipiens f. molestus. Anew taxonomic checklist is provided, annotated with respective vector competencies for transmission of arboviruses. (C) 2014 The Authors. Published by Elsevier B.V.
C1 [Gunay, Filiz; Alten, Bulent] Hacettepe Univ, Fac Sci, Dept Biol, Ecol Sect,ESRL Labs, TR-06800 Beytepe, Turkey.
[Simsek, Fatih] Adnan Menderes Univ, Fac Sci & Literature, Dept Biol, Div Ecol, TR-09010 Kepez Aydin, Turkey.
[Aldemir, Adnan] Kafkas Univ, Fac Sci & Literature, Dept Biol, TR-36100 Kars, Turkey.
[Linton, Yvonne-Marie] Walter Reed Army Inst Res, Entomol Branch, Silver Spring, MD USA.
[Linton, Yvonne-Marie] Smithsonian Inst, Museum Support Ctr, Walter Reed Biosystemat Unit, Suitland, MD 20746 USA.
[Linton, Yvonne-Marie] Smithsonian Inst, Natl Museum Nat Hist, Dept Entomol, Washington, DC 20560 USA.
[Linton, Yvonne-Marie] Uniformed Serv Univ Hlth Sci, Fac Preventat Med & Biometr, Bethesda, MD 20814 USA.
RP Linton, YM (reprint author), Walter Reed Army Inst Res, Entomol, Walter Reed Biosystemat Unit, Smithsonian Inst Museum Support Ctr, MRC-534,4210 Silver Hill Rd, Suitland, MD 20746 USA.
EM gunayf@gmail.com; kaynas@hacettepe.edu.tr; fsimsek@adu.edu.tr;
LintonY@si.edu
FU EU SYNTHESYS programme at the Natural History Museum, London;
AFHSC-GEIS-Global Emerging Infections Surveillance and Response System,
a Division of the Armed Forces Health Surveillance Center [PO327_14_WR];
EU [FP7-261504]; National Research Council (NRC) Research Associateship
Award at the Walter Reed Army Institute of Research
FX This study forms part of the PhD study of FG, and contributes to the
wider objectives of the global Mosquito Barcoding Initiative (MBI),
headed by YML and R.C. Wilkerson (Walter Reed Biosystematics Unit). We
are thankful to Ms Hilal Bedir for assisting FG and YML in the field in
August 2011 and to Dr Berna Demirci (both of Kafkas University, Kars,
Turkey) for donations of Culex specimens. Some data reported in this
manuscript was generated during a training period for FG funded through
the EU SYNTHESYS programme at the Natural History Museum, London, with
the remainder generated at the Laboratory of Analytical Biology,
Smthsonian Institution, Washington, USA. Data was analysed and prepared
for publication while YML, BA and FG held a project grant from
AFHSC-GEIS-Global Emerging Infections Surveillance and Response System,
a Division of the Armed Forces Health Surveillance Center (Project Grant
Award PO327_14_WR to YML). Field studies were supported by EU grant
FP7-261504 EDENext and is catalogued by the EDENext Steering Committee
as EDENext-269. This manuscript was prepared whilst YML held a National
Research Council (NRC) Research Associateship Award at the Walter Reed
Army Institute of Research. The material to be published reflects the
views of the authors and should not be construed to represent those of
the US Department of the Army or the US Department of Defense.
NR 83
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U2 14
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0001-706X
EI 1873-6254
J9 ACTA TROP
JI Acta Trop.
PD MAR
PY 2015
VL 143
BP 112
EP 120
DI 10.1016/j.actatropica.2014.10.013
PG 9
WC Parasitology; Tropical Medicine
SC Parasitology; Tropical Medicine
GA CC7DB
UT WOS:000350526800016
PM 25446171
ER
PT J
AU Braun, MM
Barstow, CH
Pyzocha, NJ
AF Braun, Michael M.
Barstow, Craig H.
Pyzocha, Natasha J.
TI Diagnosis and Management of Sodium Disorders: Hyponatremia and
Hypernatremia
SO AMERICAN FAMILY PHYSICIAN
LA English
DT Article
ID CLINICAL-PRACTICE GUIDELINE; HEART-FAILURE; CARDIAC-SURGERY; TOLVAPTAN;
MORTALITY; RISK; ASSOCIATION; ANTAGONIST; MORBIDITY; EXCRETION
AB Hyponatremia and hypernatremia are common findings in the inpatient and outpatient settings. Sodium disorders are associated with an increased risk of morbidity and mortality. Plasma osmolality plays a critical role in the pathophysiology and treatment of sodium disorders. Hyponatremia and hypernatremia are classified based on volume status (hypovolemia, euvolemia, and hypervolemia). Sodium disorders are diagnosed by findings from the history, physical examination, laboratory studies, and evaluation of volume status. Treatment is based on symptoms and underlying causes. In general, hyponatremia is treated with fluid restriction (in the setting of euvolemia), isotonic saline (in hypovolemia), and diuresis (in hypervolemia). A combination of these therapies may be needed based on the presentation. Hypertonic saline is used to treat severe symptomatic hyponatremia. Medications such as vaptans may have a role in the treatment of euvolemic and hypervolemic hyponatremia. The treatment of hypernatremia involves correcting the underlying cause and correcting the free water deficit. Copyright (C) 2015 American Academy of Family Physicians.
C1 [Braun, Michael M.; Pyzocha, Natasha J.] Madigan Army Med Ctr, Family Med Residency, Tacoma, WA 98431 USA.
[Barstow, Craig H.] Womack Army Med Ctr, Family Med Residency, Ft Bragg, NC USA.
RP Braun, MM (reprint author), Madigan Army Med Ctr, Family Med Residency, 9040 Fitzsimmons Dr, Tacoma, WA 98431 USA.
EM michael.m.braun.civ@mail.mil
NR 37
TC 3
Z9 3
U1 3
U2 12
PU AMER ACAD FAMILY PHYSICIANS
PI KANSAS CITY
PA 8880 WARD PARKWAY, KANSAS CITY, MO 64114-2797 USA
SN 0002-838X
EI 1532-0650
J9 AM FAM PHYSICIAN
JI Am. Fam. Physician
PD MAR 1
PY 2015
VL 91
IS 5
BP 299
EP 307
PG 9
WC Primary Health Care; Medicine, General & Internal
SC General & Internal Medicine
GA CC7HZ
UT WOS:000350539600007
PM 25822386
ER
PT J
AU Soonsawat, A
Resident, P
Ellison, J
Ahmed, I
AF Soonsawat, Anothai
Resident, Psychiatry
Ellison, James
Ahmed, Iqbal
TI Physician with Cognitive Impairment
SO AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY
LA English
DT Meeting Abstract
CT Annual Meeting of the American-Association-for-Geriatric-Psychiatry
CY MAR 27-30, 2015
CL New Orleans, LA
SP Amer Assoc Geriatr Psychiat
C1 [Resident, Psychiatry] Harvard South Shore Psychiat Residency Program, Brockton, MA USA.
[Resident, Psychiatry] VA Boston Healthcare Syst, Boston, MA USA.
[Ellison, James] McLean Hosp, Belmont, MA 02178 USA.
[Ahmed, Iqbal] Tripler Army Med Ctr, Honolulu, HI 96859 USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1064-7481
EI 1545-7214
J9 AM J GERIAT PSYCHIAT
JI Am. J. Geriatr. Psychiatr.
PD MAR
PY 2015
VL 23
IS 3
SU S
MA EI 66
BP S131
EP S132
PG 3
WC Geriatrics & Gerontology; Gerontology; Psychiatry
SC Geriatrics & Gerontology; Psychiatry
GA CD1IV
UT WOS:000350829500126
ER
PT J
AU Kragh, JF
Nam, JJ
Berry, KA
Mase, VJ
Aden, JK
Walters, TJ
Dubick, MA
Baer, DG
Wade, CE
Blackbourne, LH
AF Kragh, John F.
Nam, Jason J.
Berry, Keith A.
Mase, Vincent J., Jr.
Aden, James K., III
Walters, Thomas J.
Dubick, Michael A.
Baer, David G.
Wade, Charles E.
Blackbourne, Lorne H.
TI Transfusion for Shock in US Military War Casualties With and Without
Tourniquet Use
SO ANNALS OF EMERGENCY MEDICINE
LA English
DT Article
ID MAJOR LIMB TRAUMA; WOUNDS; CARE
AB Study objective: We assess whether emergency tourniquet use for transfused war casualties admitted to military hospitals is associated with survival.
Methods: A retrospective review of trauma registry data was made of US casualties in Afghanistan and Iraq. Patients with major limb trauma, transfusion, and tourniquet use were compared with similar patients who did not receive tourniquet use. A propensity-matching analysis was performed by stratifying for injury type and severity by tourniquet-use status. Additionally, direct comparison without propensity matching was made between tourniquet use and no-tourniquet use groups.
Results: There were 720 casualties in the tourniquet use and 693 in the no-tourniquet use groups. Of the 1,413 casualties, 66%(928) also had nonextremity injury. Casualties with tourniquet use had worse signs of hemorrhagic shock (admission base deficit, admission hemoglobin, admission pulse, and transfusion units required) than those without. Survival rates were similar between the 2 groups (1% difference; 95% confidence interval 2.5% to 4.2%), but casualties who received tourniquets had worse shock and received more blood products. In propensity-matched casualties, survival rates were not different (2% difference; 95% confidence interval 6.7% to 2.7%) between the 2 groups.
Conclusion: Tourniquet use was associated with worse shock and more transfusion requirements among hospital-admitted casualties, yet those who received tourniquets had survival rates similar to those of comparable, transfused casualties who did not receive tourniquets.
C1 [Kragh, John F.; Dubick, Michael A.] JBSA Ft Sam, Damage Control Resuscitat, Houston, TX 78234 USA.
[Aden, James K., III; Walters, Thomas J.; Baer, David G.] JBSA Ft Sam, US Army, Inst Surg Res, Houston, TX USA.
[Kragh, John F.] Uniformed Serv Univ Hlth Sci, F Edward Hebert Sch Med, Bethesda, MD 20814 USA.
[Nam, Jason J.] Walter Reed Natl Mil Med Ctr, Bethesda, MD USA.
[Berry, Keith A.] Penn State Univ, Milton S Hershey Med Ctr, Hershey, PA 17033 USA.
[Mase, Vincent J., Jr.] Brian Allgood Army Community Hosp, Seoul, South Korea.
[Wade, Charles E.] Univ Texas Houston, Med Sch Houston, Houston, TX USA.
[Blackbourne, Lorne H.] JBSA Ft Sam, San Antonio Mil Med Ctr, Houston, TX USA.
RP Kragh, JF (reprint author), JBSA Ft Sam, Damage Control Resuscitat, Houston, TX 78234 USA.
EM john.f.kragh.civ@mail.mil
FU USAISR funds; Defense Health Program [201105]
FX By Annals policy, all authors are required to disclose any and all
commercial, financial, and other relationships in any way related to the
subject of this article as per ICMJE conflict of interest guidelines
(see www.icmje.org). This project was funded with internal USAISR funds
and the Defense Health Program (proposal 201105).
NR 12
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Z9 12
U1 0
U2 5
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0196-0644
J9 ANN EMERG MED
JI Ann. Emerg. Med.
PD MAR
PY 2015
VL 65
IS 3
BP 290
EP 296
DI 10.1016/j.annemergmed.2014.10.021
PG 7
WC Emergency Medicine
SC Emergency Medicine
GA CC9QN
UT WOS:000350705800013
PM 25458979
ER
PT J
AU Hammond, RT
AF Hammond, Richard T.
TI Negative mass
SO EUROPEAN JOURNAL OF PHYSICS
LA English
DT Article
DE negative mass; general relativity; string theory
ID GENERAL-RELATIVITY; SUPERNOVAE; WORMHOLES; REVERSAL; UNIVERSE
AB Some physical aspects of negative mass are examined. Several unusual properties, such as the ability of negative mass to penetrate any armor, are analysed. Other surprising effects include the bizarre system of negative mass chasing positive mass, naked singularities and the violation of cosmic cen-sorship, wormholes, and quantum mechanical results as well. In addition, a brief look into the implications for strings is given.
C1 [Hammond, Richard T.] Univ N Carolina, Dept Phys, Chapel Hill, NC 27599 USA.
[Hammond, Richard T.] Army Res Off, Res Triangle Pk, NC USA.
RP Hammond, RT (reprint author), Univ N Carolina, Dept Phys, Chapel Hill, NC 27599 USA.
EM rhammond@email.unc.edu
NR 28
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U1 1
U2 8
PU IOP PUBLISHING LTD
PI BRISTOL
PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND
SN 0143-0807
EI 1361-6404
J9 EUR J PHYS
JI Eur. J. Phys.
PD MAR
PY 2015
VL 36
IS 2
AR 025005
DI 10.1088/0143-0807/36/2/025005
PG 11
WC Education, Scientific Disciplines; Physics, Multidisciplinary
SC Education & Educational Research; Physics
GA CD1YI
UT WOS:000350870200005
ER
PT J
AU Smith, TJ
Hill, KK
Xie, G
Foley, BT
Williamson, CHD
Foster, JT
Johnson, SL
Chertkov, O
Teshima, H
Gibbons, HS
Johnsky, LA
Karavis, MA
Smith, LA
AF Smith, Theresa J.
Hill, Karen K.
Xie, Gary
Foley, Brian T.
Williamson, Charles H. D.
Foster, Jeffrey T.
Johnson, Shannon L.
Chertkov, Olga
Teshima, Hazuki
Gibbons, Henry S.
Johnsky, Lauren A.
Karavis, Mark A.
Smith, Leonard A.
TI Genomic sequences of six botulinum neurotoxin-producing strains
representing three clostridial species illustrate the mobility and
diversity of botulinum neurotoxin genes
SO INFECTION GENETICS AND EVOLUTION
LA English
DT Article
DE Clostridium botulinum; Clostridium argentinense; Clostridium baratii;
Botulinum neurotoxin
ID INFANT BOTULISM; UNITED-STATES; COMPLEX GENES; TOXIN; CLUSTERS; PLASMID;
IDENTIFICATION; PERFORMANCE; ANNOTATION; ALGORITHMS
AB The whole genomes for six botulinum neurotoxin-producing clostridial strains were sequenced to provide references for under-represented toxin types, bivalent strains or unusual toxin complexes associated with a bont gene. The strains include three Clostridium botulinum Group I strains (CDC 297, CDC 1436, and Prevot 594), a Group II C. botulinum strain (Eklund 202F), a Group IV Clostridium argentinense strain (CDC 2741), and a Group V Clostridium baratii strain (Sullivan). Comparisons of the Group I genomic sequences revealed close relationships and conservation of toxin gene locations with previously published Group I C. botulinum genomes. The bont/F6 gene of strain Eklund 202F was determined to be a chimeric toxin gene composed of bont/F1 and bont/F2. The serotype G strain CDC 2741 remained unfinished in 20 contigs with the bont/G located within a 1.15 Mb contig, indicating a possible chromosomal location for this toxin gene. Within the genome of C. baratii Sullivan strain, direct repeats of IS1182 insertion sequence (IS) elements were identified flanking the bont/F7 toxin complex that may be the mechanism of bont insertion into C. baratii. Highlights of the six strains are described and release of their genomic sequences will allow further study of unusual neurotoxin-producing clostridial strains. Published by Elsevier B.V.
C1 [Smith, Theresa J.] US Army Med Res Inst Infect Dis, Mol & Translat Sci Div, Ft Detrick, MD 21702 USA.
[Hill, Karen K.; Xie, Gary; Johnson, Shannon L.; Chertkov, Olga; Teshima, Hazuki] Los Alamos Natl Lab, Biosci Div, Los Alamos, NM 87545 USA.
[Foley, Brian T.] Los Alamos Natl Lab, Div Theoret, Los Alamos, NM 87545 USA.
[Williamson, Charles H. D.; Foster, Jeffrey T.] No Arizona Univ, Ctr Microbial Genet & Genom, Flagstaff, AZ 86011 USA.
[Gibbons, Henry S.; Johnsky, Lauren A.; Karavis, Mark A.] Edgewood Chem Biol Ctr, Biosci Div, Aberdeen Proving Ground, MD 21010 USA.
[Smith, Leonard A.] US Army Med Res Inst Infect Dis, US Army Med Res & Mat Command, Med Countermeasures Technol, Ft Detrick, MD 21702 USA.
RP Smith, TJ (reprint author), US Army Med Res Inst Infect Dis, Mol & Translat Sci Div, 1425 Porter St, Ft Detrick, MD 21702 USA.
EM theresa.j.smith.civ@mail.mil
OI Foley, Brian/0000-0002-1086-0296; Foster, Jeffrey/0000-0001-8235-8564;
xie, gary/0000-0002-9176-924X
FU Department of Homeland Security, Science and Technology Directorate;
National Institute of Allergy and Infectious Diseases [U01AI056493]
FX Funding for this research was provided by the Department of Homeland
Security, Science and Technology Directorate and also supported by
U01AI056493 from the National Institute of Allergy and Infectious
Diseases. The content is solely the responsibility of the authors and
does not necessarily represent the official views of the National
Institute of Allergy and Infectious Diseases or the National Institutes
of Health. We also thank the Department of Energy Joint Genome Institute
for their support in providing technical assistance and facilities for
DNA sequencing. Opinions, interpretations, conclusions and
recommendations are those of the authors and not necessarily endorsed by
the U.S. Army.
NR 63
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U1 1
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PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1567-1348
EI 1567-7257
J9 INFECT GENET EVOL
JI Infect. Genet. Evol.
PD MAR
PY 2015
VL 30
BP 102
EP 113
DI 10.1016/j.meegid.2014.12.002
PG 12
WC Infectious Diseases
SC Infectious Diseases
GA CC7CN
UT WOS:000350525400015
PM 25489752
ER
PT J
AU Brown, TS
Jacob, CG
Silva, JC
Takala-Harrison, S
Djimde, A
Dondorp, AM
Fukuda, M
Noedl, H
Nyunt, MM
Kyaw, MP
Mayxay, M
Hien, TT
Plowe, CV
Cummings, MP
AF Brown, Tyler S.
Jacob, Christopher G.
Silva, Joana C.
Takala-Harrison, Shannon
Djimde, Abdoulaye
Dondorp, Arjen M.
Fukuda, Mark
Noedl, Harald
Nyunt, Myaing Myaing
Kyaw, Myat Phone
Mayxay, Mayfong
Tran Tinh Hien
Plowe, Christopher V.
Cummings, Michael P.
TI Plasmodium falciparum field isolates from areas of repeated emergence of
drug resistant malaria show no evidence of hypermutator phenotype
SO INFECTION GENETICS AND EVOLUTION
LA English
DT Article
DE Plasmodium falciparum; Drug resistance; Artemisinin; Mutation rate;
Molecular evolution
ID MUTATIONS; RATES; RECOMBINATION; CLEARANCE; DIVERSITY; ORIGINS; MAMMALS;
SPREAD; MAP
AB Multiple transcontinental waves of drug resistance in Plasmodium falciparum have originated in Southeast Asia before spreading westward, first into the rest of Asia and then to sub-Saharan Africa. In vitro studies have suggested that hypermutator P. falciparum parasites may exist in Southeast Asia and that an increased rate of acquisition of new mutations in these parasites may explain the repeated emergence of drug resistance in Southeast Asia. This study is the first to test the hypermutator hypothesis using field isolates. Using genome-wide SNP data from human P. falciparum infections in Southeast Asia and West Africa and a test for relative rate differences we found no evidence of increased relative substitution rates in P. falciparum isolates from Southeast Asia. Instead, we found significantly increased substitution rates in Mali and Bangladesh populations relative to those in populations from Southeast Asia. Additionally we found no association between increased relative substitution rates and parasite clearance following treatment with artemisinin derivatives. (C) 2015 Elsevier B.V. All rights reserved.
C1 [Djimde, Abdoulaye] Univ Sci Technol & Technol Bamako, Fac Med & Pharmacy, Dept Epidemiol Parasit Dis, Malaria Res & Training Ctr, Bamako, Mali.
[Dondorp, Arjen M.] Mahidol Univ, Fac Trop Med, Mahidol Oxford Trop Med Res Unit, Bangkok, Thailand.
[Dondorp, Arjen M.] Univ Oxford, Churchill Hosp, Nuffield Dept Med, Ctr Trop Med, Oxford, England.
[Brown, Tyler S.; Jacob, Christopher G.; Takala-Harrison, Shannon; Nyunt, Myaing Myaing; Plowe, Christopher V.] Univ Maryland, Sch Med, Howard Hughes Med Inst, Ctr Vaccine Dev, Baltimore, MD 21201 USA.
[Noedl, Harald] Med Univ Vienna, Austria & Malaria Res Initiat Bandarban, Inst Specif Prophylaxis & Trop Med, Bandarban, Bangladesh.
[Silva, Joana C.] Univ Maryland, Sch Med, Inst Genome Sci, Baltimore, MD 21201 USA.
[Silva, Joana C.] Univ Maryland, Sch Med, Dept Microbiol & Immunol, Baltimore, MD 21201 USA.
[Mayxay, Mayfong] Mahosot Hosp, Microbiol Lab, Lao Oxford Mahosot Hosp Wellcome Trust Res Unit L, Viangchan, Laos.
[Mayxay, Mayfong] Univ Hlth Sci, Fac Postgrad Studies, Viangchan, Laos.
[Fukuda, Mark] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand.
[Cummings, Michael P.] Univ Maryland, Ctr Bioinformat & Computat Biol, Lab Mol Evolut, College Pk, MD 20742 USA.
[Kyaw, Myat Phone] Dept Med Res Lower Myanmar, Yangon, Myanmar.
[Tran Tinh Hien] Univ Oxford, Clin Res Unit Vietnam OUCRU, Ctr Trop Med, Ho Chi Minh City, Vietnam.
[Brown, Tyler S.] Johns Hopkins Univ, Sch Med, Baltimore, MD USA.
RP Cummings, MP (reprint author), Univ Maryland, College Pk, MD 20742 USA.
EM mike@umiacs.umd.edu
FU National Institute of Allergy and Infectious Diseases [R03AI101680,
R01AI101713, U19AI10820]; Howard Hughes Medical Institute
FX We thank the Malaria Programme staff at the Wellcome Trust Sanger
Institute, including Dominic Kwiatkowski, Olivo Miotto, Bronwyn
Maclnnis, Daniel Mead, Eleanor Drury, Susana Campino, Magnus Mankse, and
James Stalker, who generated the whole genome sequencing data. In
addition, we thank Dr. Timothy O'Connor for his constructive feedback on
the manuscript. This work was supported by grants R03AI101680 (C.V.P.)
and R01AI101713 (S.T.-H.) and U19AI10820 (J.C.S., C.V.P) from the
National Institute of Allergy and Infectious Diseases and by the Howard
Hughes Medical Institute. T.S.B. was a Howard Hughes Medical Institute
Medical Research Fellow.
NR 32
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U1 1
U2 6
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1567-1348
EI 1567-7257
J9 INFECT GENET EVOL
JI Infect. Genet. Evol.
PD MAR
PY 2015
VL 30
BP 318
EP 322
DI 10.1016/j.meegid.2014.12.010
PG 5
WC Infectious Diseases
SC Infectious Diseases
GA CC7CN
UT WOS:000350525400040
PM 25514047
ER
PT J
AU Zasowski, E
Bland, CM
Tam, VH
Lodise, TP
AF Zasowski, Evan
Bland, Christopher M.
Tam, Vincent H.
Lodise, Thomas P.
TI Identification of optimal renal dosage adjustments for high-dose
extended-infusion cefepime dosing regimens in hospitalized patients
SO JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
LA English
DT Article
DE antibiotic therapy; Monte Carlo simulations; pharmacodynamics;
pharmacokinetics
ID BETA-LACTAM ANTIBIOTICS; CRITICALLY-ILL PATIENTS;
PSEUDOMONAS-AERUGINOSA; PROLONGED-INFUSION; PHARMACODYNAMICS;
PHARMACOKINETICS; INFECTIONS; IMPAIRMENT; MORTALITY
AB Objectives: The objective of this study was to identify optimal renal dose adjustments for 2 g of cefepime every 8 h as a 3 h infusion where the probability of target attainment was optimized and drug accumulation was minimal.
Methods: Embedded with a population pharmacokinetic model derived in a population of hospitalized patients with varying degrees of renal function, a series of 5000-subject Monte Carlo simulations using ADAPT 5 were performed for 3 h infusions of 2 g every 6, 8, 12 and 24 h. To assess exposure profiles across various levels of renal function, the estimated CLCR was fixed at values between 20 and 150 mL/min. For each regimen examined, the fraction of simulated subjects who achieved free drug concentrations in excess of the MIC for >= 60% of the dosing interval (60% fT>MIC) at the various CLCR levels was determined and this information was used to identify optimal renal dose adjustments without profound drug exposure.
Results: In the Monte Carlo simulations, modification of the parent regimen (2 g every 8 h) to 2 g every 6 h for CLCR >120 mL/min and extension of the dosing interval to every 12 and 24 h at CLCR of 60 and 20 mL/min, respectively, provided favourable probability of target attainment profiles without profound drug exposure.
Conclusions: The findings from this study identified renal dose alteration regimens that yielded favourable pharmacodynamic profiles without excessive drug exposure. As these findings were based on mathematical models, they should be validated in the clinical arena.
C1 [Zasowski, Evan; Lodise, Thomas P.] Albany Coll Pharm & Hlth Sci, Albany, NY 12208 USA.
[Bland, Christopher M.] Dwight D Eisenhower Army Med Ctr, Ft Gordon, GA USA.
[Tam, Vincent H.] Univ Houston, Coll Pharm, Houston, TX 77030 USA.
RP Lodise, TP (reprint author), Albany Coll Pharm & Hlth Sci, Albany, NY 12208 USA.
EM thomas.lodise@acphs.edu
NR 21
TC 4
Z9 4
U1 1
U2 4
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0305-7453
EI 1460-2091
J9 J ANTIMICROB CHEMOTH
JI J. Antimicrob. Chemother.
PD MAR
PY 2015
VL 70
IS 3
BP 877
EP 881
DI 10.1093/jac/dku435
PG 5
WC Infectious Diseases; Microbiology; Pharmacology & Pharmacy
SC Infectious Diseases; Microbiology; Pharmacology & Pharmacy
GA CC2ZV
UT WOS:000350214700033
PM 25381169
ER
PT J
AU Gaydos, SJ
Kelley, AM
Grandizio, CM
Athy, JR
Walters, PL
AF Gaydos, Steven J.
Kelley, Amanda M.
Grandizio, Catherine M.
Athy, Jeremy R.
Walters, P. Lynne
TI COMPARISON OF THE EFFECTS OF KETAMINE AND MORPHINE ON PERFORMANCE OF
REPRESENTATIVE MILITARY TASKS
SO JOURNAL OF EMERGENCY MEDICINE
LA English
DT Article
DE prehospital care; military medicine; soldier skills
ID LOW-DOSE KETAMINE; PAIN MANAGEMENT; CARE; OPIOIDS; MEMORY; ADULTS; TRIAL
AB Background: When providing care under combat or hostile conditions, it may be necessary for a casualty to remain engaged in military tasks after being wounded. Prehospital care under other remote, austere conditions may be similar, whereby an individual may be forced to continue purposeful actions despite traumatic injury. Given the adverse side-effect profile of intramuscular (i.m.) morphine, alternative analgesics and routes of administration are of interest. Ketamine may be of value in this capacity. Objectives: To delineate performance decrements in basic soldier tasks comparing the effects of the standard battlefield analgesic (10 mg i.m. morphine) with 25 mg i.m. ketamine. Methods: Representative military skills and risk propensity were tested in 48 healthy volunteers without pain stimuli in a double-blind, placebo-controlled, crossover design. Results: Overall, participants reported more symptoms associated with ketamine vs. morphine and placebo, chiefly dizziness, poor concentration, and feelings of happiness. Performance decrements on ketamine, when present, manifested as slower performance times rather than procedural errors. Conclusions: Participants were more symptomatic with ketamine, yet the soldier skills were largely resistant to performance decrements, suggesting that a trained task skill (autonomous phase) remains somewhat resilient to the drugged state at this dosage. The performance decrements with ketamine may represent the subjects' adoption of a cautious posture, as suggested by risk propensity testing whereby the subject is aware of impairment, trading speed for preservation of task accuracy. These results will help to inform the casualty care community regarding appropriate use of ketamine as an alternative or opioid-sparing battlefield analgesic. Published by Elsevier Inc.
C1 [Gaydos, Steven J.; Kelley, Amanda M.; Grandizio, Catherine M.; Athy, Jeremy R.; Walters, P. Lynne] US Army Aeromed Res Lab, Ft Rucker, AL 36362 USA.
RP Gaydos, SJ (reprint author), US Army Aeromed Res Lab, Warfighter Performance & Hlth Div, 6901 Farrell Rd, Ft Rucker, AL 36362 USA.
FU U.S. Army Medical Research and Materiel Command's Combat Casualty Care
Research Program; U.S. Army Combat Casualty Care Research Program
FX The authors would like to acknowledge the dedication and professionalism
of the research staff of the War-fighter Health Division, U.S. Army
Aeromedical Research Laboratory, for their contributions to this
project. This study was funded by the U.S. Army Medical Research and
Materiel Command's Combat Casualty Care Research Program. A detailed
technical report of this study is available by contacting the USAARL
Science Information Center at 334-255-6907. The study was approved by
the U.S. Army Medical Research and Materiel Command Office of Research
Protections Institutional Review Board. There are no financial or other
relationships that may be perceived as a conflict of interest. This
study was sponsored by the U.S. Army Combat Casualty Care Research
Program.
NR 35
TC 1
Z9 1
U1 1
U2 4
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0736-4679
EI 1090-1280
J9 J EMERG MED
JI J. Emerg. Med.
PD MAR
PY 2015
VL 48
IS 3
BP 313
EP 324
DI 10.1016/j.jemermed.2014.06.047
PG 12
WC Emergency Medicine
SC Emergency Medicine
GA CC7XH
UT WOS:000350581300014
PM 25271185
ER
PT J
AU Malone, CA
AF Malone, Christina A.
TI Photographic Analyses Using Skin Detail of the Hand: A Methodology and
Evaluation
SO JOURNAL OF FORENSIC SCIENCES
LA English
DT Article
DE forensic science; image analysis; photographic comparison; human
identification; skin manifestations; skin pigmentation
AB Skin features have been employed by law enforcement agencies for suspect and victim identification. Comparisons of hand have arisen in casework where images have been submitted where a face was not present but a hand was visible. This research utilizes a collection of 128 hands from employees of the U.S. Army Criminal Investigation Laboratory to examine the frequency and distribution of skin detail on the dorsal surface of the hand. To assess the location of features, the hand was segmented into 14 regions using readily discernible anatomical landmarks. Overall, 2618 pigmented lesions and 92 scars or injuries were documented. When comparing the regions with one another, Regions 1-10 had fewer pigmented lesions than Regions 11-14. There was no pattern to the distribution of scars throughout the regions. The findings presented a foundation for one possible method that may differentiate hands based on the frequency and distribution of such features.
C1 [Malone, Christina A.] US Army, Criminal Invest Lab, Digital Evidence, Def Forens Sci Ctr, Forest Pk, GA 30297 USA.
RP Malone, CA (reprint author), US Army, Criminal Invest Lab, Digital Evidence, 4930 N 31st St, Forest Pk, GA 30297 USA.
EM christina.a.malone.civ@mail.mil
NR 12
TC 3
Z9 3
U1 0
U2 3
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0022-1198
EI 1556-4029
J9 J FORENSIC SCI
JI J. Forensic Sci.
PD MAR
PY 2015
VL 60
IS 2
BP 326
EP 330
DI 10.1111/1556-4029.12670
PG 5
WC Medicine, Legal
SC Legal Medicine
GA CD0LM
UT WOS:000350764300007
PM 25443598
ER
PT J
AU Pasiakos, SM
Lieberman, HR
Fulgoni, VL
AF Pasiakos, Stefan M.
Lieberman, Harris R.
Fulgoni, Victor L., III
TI Higher-Protein Diets Are Associated with Higher HDL Cholesterol and
Lower BMI and Waist Circumference in US Adults
SO JOURNAL OF NUTRITION
LA English
DT Article
DE recommended dietary allowance; body mass index; waist circumference;
high-density lipoprotein; NHANES
ID RANDOMIZED CONTROLLED-TRIALS; LOW-CARBOHYDRATE DIETS; LOW-FAT DIETS;
WEIGHT-LOSS; BODY-COMPOSITION; RISK-FACTORS; AMINO-ACIDS; BLOOD-LIPIDS;
OBESE ADULTS; WOMEN
AB Background: Protein intake above the RDA attenuates cardiometabolic risk in overweight and obese adults during weight loss. However, the cardiometabolic consequences of consuming higher-protein diets in free-living adults have not been determined.
Objective: This study examined usual protein intake [g/kg body weight (BW)] patterns stratified by weight status and their associations with cardiometabolic risk using data from the NHANES, 2001-2010 (n = 23,876 adults >= 19 y of age).
Methods: Linear and decile trends for association of usual protein intake with cardiometabolic risk factors including blood pressure, glucose, insulin, cholesterol, and triglycerides were determined with use of models that controlled for age, sex, ethnicity, physical activity, poverty-income ratio, energy intake (kcal/d), carbohydrate (g/kg BW) and total fat (g/kg BW) intake, body mass index (BMI), and waist circumference.
Results: Usual protein intake varied across deciles from 0.69 +/- 0.004 to 1.51 +/- 0.009 g/kg BW (means +/- SEs). Usual protein intake was inversely associated with BMI (-0.47 kg/m(2) per decile and -4.54 kg/m(2) per g/kg BW) and waist circumference (-0.53 cm per decile and -2.45 cm per g/kg BW), whereas a positive association was observed between protein intake and HDL cholesterol (0.01 mmol/L per decile and 0.14 mmol/L per g/kg BW, P < 0.00125).
Conclusions: Americans of all body weights typically consume protein in excess of the RDA. Higher-protein diets are associated with lower BMI and waist circumference and higher HDL cholesterol compared to protein intakes at RDA levels. Our data suggest that Americans who consume dietary protein between 1.0 and 1.5 g/kg BW potentially have a lower risk of developing cardiometabolic disease.
C1 [Pasiakos, Stefan M.; Lieberman, Harris R.] US Army Res Inst Environm Med, Mil Nutr Div, Natick, MA 01760 USA.
[Fulgoni, Victor L., III] Oak Ridge Inst Sci & Educ, Oak Ridge, TN USA.
[Fulgoni, Victor L., III] Nutr Impact LLC, Battle Creek, MI USA.
RP Pasiakos, SM (reprint author), US Army Res Inst Environm Med, Mil Nutr Div, Natick, MA 01760 USA.
EM stefan.pasiakos@us.army.mil
RI Pasiakos, Stefan/E-6295-2014
OI Pasiakos, Stefan/0000-0002-5378-5820
FU US Army Military Research and Materiel Command; Department of Defense
Center Alliance for Dietary Supplements Research
FX Supported by the US Army Military Research and Materiel Command and the
Department of Defense Center Alliance for Dietary Supplements Research.
NR 50
TC 5
Z9 5
U1 3
U2 15
PU AMER SOC NUTRITION-ASN
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0022-3166
EI 1541-6100
J9 J NUTR
JI J. Nutr.
PD MAR
PY 2015
VL 145
IS 3
BP 605
EP 614
DI 10.3945/jn.114.205203
PG 10
WC Nutrition & Dietetics
SC Nutrition & Dietetics
GA CC5RM
UT WOS:000350420400031
PM 25733478
ER
PT J
AU Hu, SW
Choi, J
Chan, AL
Schwartz, WR
AF Hu, Shuowen
Choi, Jonghyun
Chan, Alex L.
Schwartz, William Robson
TI Thermal-to-visible face recognition using partial least squares
SO JOURNAL OF THE OPTICAL SOCIETY OF AMERICA A-OPTICS IMAGE SCIENCE AND
VISION
LA English
DT Article
ID LIGHT IMAGES; IR
AB Although visible face recognition has been an active area of research for several decades, cross-modal face recognition has only been explored by the biometrics community relatively recently. Thermal-to-visible face recognition is one of the most difficult cross-modal face recognition challenges, because of the difference in phenomenology between the thermal and visible imaging modalities. We address the cross-modal recognition problem using a partial least squares (PLS) regression-based approach consisting of preprocessing, feature extraction, and PLS model building. The preprocessing and feature extraction stages are designed to reduce the modality gap between the thermal and visible facial signatures, and facilitate the subsequent one-vs-all PLS-based model building. We incorporate multi-modal information into the PLS model building stage to enhance cross-modal recognition. The performance of the proposed recognition algorithm is evaluated on three challenging datasets containing visible and thermal imagery acquired under different experimental scenarios: time-lapse, physical tasks, mental tasks, and subject-to-camera range. These scenarios represent difficult challenges relevant to real-world applications. We demonstrate that the proposed method performs robustly for the examined scenarios. (C) 2015 Optical Society of America
C1 [Hu, Shuowen; Chan, Alex L.] US Army Res Lab, Adelphi, MD 20783 USA.
[Choi, Jonghyun] Univ Maryland, College Pk, MD 20742 USA.
[Schwartz, William Robson] Univ Fed Minas Gerais, BR-31270901 Belo Horizonte, MG, Brazil.
RP Hu, SW (reprint author), US Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA.
EM shuowen.hu.civ@mail.mil
FU Brazilian National Research Council-CNPq [477457/2013-4]; Minas Gerais
Research Foundation-FAPEMIG [APQ-01806-13]
FX The authors would like to thank the sponsors of this project for their
guidance, Dr. Julie Skipper for sharing the WSRI data-set, and Dr.
Kenneth Byrd for the NVESD dataset collection effort. W. R. Schwartz
would like to thank the Brazilian National Research Council-CNPq (Grant
# 477457/2013-4) and the Minas Gerais Research Foundation-FAPEMIG (Grant
APQ-01806-13).
NR 36
TC 14
Z9 14
U1 2
U2 7
PU OPTICAL SOC AMER
PI WASHINGTON
PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA
SN 1084-7529
EI 1520-8532
J9 J OPT SOC AM A
JI J. Opt. Soc. Am. A-Opt. Image Sci. Vis.
PD MAR 1
PY 2015
VL 32
IS 3
BP 431
EP 442
DI 10.1364/JOSAA.32.000431
PG 12
WC Optics
SC Optics
GA CC9BP
UT WOS:000350662800010
PM 26366654
ER
PT J
AU Proffitt, A
Faulconer, R
Kreishman, P
Graybill, S
Craig, D
AF Proffitt, Adrian
Faulconer, R.
Kreishman, P.
Graybill, S.
Craig, D.
TI An unusual cause of peritonitis in a deployed environment
SO JOURNAL OF THE ROYAL ARMY MEDICAL CORPS
LA English
DT Article
ID FAMILIAL MEDITERRANEAN FEVER; PREVALENCE
AB Acute abdominal pain is a common presenting complaint to both primary and secondary care, and is a frequent cause of hospital admission among deployed personnel. Identification of generalised peritonism on abdominal examination is a classical indicator of intra-abdominal pathology that may warrant exploratory laparotomy. Negative findings at laparotomy should serve as a diagnostic prompt to consider other non-surgical mimics of an acute abdomen.
C1 [Proffitt, Adrian] Univ Hosp North Staffordshire, Dept Med, Acute Internal Med ST3, Stoke On Trent ST4 6QG, Staffs, England.
[Faulconer, R.] Russells Hall Hosp, Dept Surg, Gen & Vasc Surg ST5, Dudley, W Midlands, England.
[Kreishman, P.] Womack Mil Med Ctr, Dept Surg, Ft Bragg, NC USA.
[Graybill, S.] San Antonio Mil Med Ctr, Dept Internal Med, Ft Sam Houston, TX USA.
[Craig, D.] James Cook Univ Hosp, Dept Gastroenterol, Middlesbrough, N Yorkshire, England.
RP Proffitt, A (reprint author), Univ Hosp North Staffordshire, Dept Med, Stoke On Trent ST4 6QG, Staffs, England.
EM adrianproffitt@doctors.org.uk
NR 9
TC 0
Z9 0
U1 0
U2 0
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 0035-8665
EI 2052-0468
J9 J ROY ARMY MED CORPS
JI J. R. Army Med. Corps
PD MAR
PY 2015
VL 161
IS 1
BP 69
EP 70
DI 10.1136/jramc-2013-000185
PG 2
WC Medicine, General & Internal
SC General & Internal Medicine
GA CC7VB
UT WOS:000350575400016
PM 24254746
ER
PT J
AU Kim, SW
Melby, JA
Nadal-Caraballo, NC
Ratcliff, J
AF Kim, Seung-Woo
Melby, Jeffrey A.
Nadal-Caraballo, Norberto C.
Ratcliff, Jay
TI A time-dependent surrogate model for storm surge prediction based on an
artificial neural network using high-fidelity synthetic hurricane
modeling
SO NATURAL HAZARDS
LA English
DT Article
DE Time-dependent surrogate model; Artificial neural network; Storm surge;
High-fidelity model
ID SEA-LEVEL VARIATIONS; SWAN PLUS ADCIRC; WAVE; HARBOR
AB Expedient prediction of storm surge is required for emergency managers to make critical decisions for evacuation, structure closure, and other emergency responses. However, time-dependent storm surge models do not exist for fast and accurate prediction in very short periods on the order of seconds to minutes. In this paper, a time-dependent surrogate model of storm surge is developed based on an artificial neural network with synthetic simulations of hurricanes. The neural network between six input hurricane parameters and one target parameter, storm surge, is trained by a feedforward backpropagation algorithm at each of 92 uniform time steps spanning 45.5 h for each storm. The basis data consist of 446 tropical storms developed from a joint probability model that was based on historical tropical storm activity in the Gulf of Mexico. Each of the 446 storms was modeled at high fidelity using a coupled storm surge and nearshore wave model. Storm surge is predicted by the 92 trained networks for approaching hurricane climatological and track parameters in a few seconds. Furthermore, the developed surrogate model is validated with measured data and high-fidelity simulations of two historical hurricanes at four points in southern Louisiana. In general, the neural networks at or near the boundary between land and ocean are well trained and model predictions are of similar accuracy to the basis modeling suites. Networks based on modeling results from complex inland locations are relatively poorly trained.
C1 [Kim, Seung-Woo] Dynam Solut LLC, Hydraul & Hydrodynam Grp, Knoxville, TN 37919 USA.
[Melby, Jeffrey A.; Nadal-Caraballo, Norberto C.; Ratcliff, Jay] US Army Engineer Res & Dev Ctr, Coastal & Hydraul Lab, Vicksburg, MS 39180 USA.
RP Melby, JA (reprint author), US Army Engineer Res & Dev Ctr, Coastal & Hydraul Lab, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA.
EM jeffrey.a.melby@usace.army.mil
FU US Army Corps of Engineers, Engineer Research and Development Center,
Coastal and Hydraulics Laboratory; National Research Foundation of Korea
(NRF) - Ministry of Education, Science and Technology
[2012R1A6A3A03038355]
FX This work was done under contract with the US Army Corps of Engineers,
Engineer Research and Development Center, Coastal and Hydraulics
Laboratory and was also supported by Basic Science Research Program
through the National Research Foundation of Korea (NRF) funded by the
Ministry of Education, Science and Technology (No. 2012R1A6A3A03038355).
In particular, the contribution of Prof. Casey Dietrich in providing the
high-fidelity simulations and precious comments is greatly appreciated.
NR 39
TC 1
Z9 1
U1 2
U2 7
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0921-030X
EI 1573-0840
J9 NAT HAZARDS
JI Nat. Hazards
PD MAR
PY 2015
VL 76
IS 1
BP 565
EP 585
DI 10.1007/s11069-014-1508-6
PG 21
WC Geosciences, Multidisciplinary; Meteorology & Atmospheric Sciences;
Water Resources
SC Geology; Meteorology & Atmospheric Sciences; Water Resources
GA CC4LZ
UT WOS:000350326200029
ER
PT J
AU Heimann, DC
Morris, DM
Gemeinhardt, TR
AF Heimann, D. C.
Morris, D. M.
Gemeinhardt, T. R.
TI NUTRIENT CONTRIBUTIONS FROM ALLUVIAL SOILS ASSOCIATED WITH THE
RESTORATION OF SHALLOW WATER HABITAT IN THE LOWER MISSOURI RIVER
SO RIVER RESEARCH AND APPLICATIONS
LA English
DT Article
DE shallow water habitat; side-channel chutes; Missouri River; river
restoration; alluvial soils
ID MISSISSIPPI RIVER; DAM REMOVAL; LOUISIANA; HYPOXIA
AB The Missouri River has been extensively altered as the result of channelization, bank stabilization, and the construction of six main stem reservoirs. In response to the resultant habitat loss, the US Army Corps of Engineers was tasked with restoring approximately 8100ha of shallow water habitat (SWH), in part, for the benefit of the endangered pallid sturgeon (Scaphirhynchus albus). Construction of off-channel habitats involves the removal and disposal of excavated alluvium either by direct discharge into the river or by secondary erosion, which raised concerns regarding the introduction of sediment and associated nutrients into the Missouri River. Soils from nine side-channel chutes were sampled to represent nutrient concentrations from habitat restoration activities. Soils from 12 historically undisturbed sites were also sampled to represent reference conditions in the Missouri River flood plain. The results of this study indicate that nutrient characteristics of soils from selected SWH locations generally are similar to those of historically undisturbed soils. The estimated mass of total phosphorus from chutes accounted for 1.9% of Missouri River and 0.5% of Mississippi River total phosphorus loads during the 1993-2012 analysis period. The mass of nitrate, the constituent most closely related to gulf hypoxia, was 0.01% or less of the Missouri and Mississippi River nitrate loads. Sediment volumes from the chutes accounted for 3.1 and 1.5% of total suspended loads from the Missouri and Mississippi Rivers. Overall, the introduced sediment from side-channel chute construction associated with SWH restoration accounts for a small portion of total nutrient and sediment transport in the Missouri and Mississippi Rivers. Published 2014. This article is a U.S. Government work and is in the public domain in the USA. River Research and Applications published by John Wiley & Sons, Ltd.
C1 [Heimann, D. C.] US Geol Survey, Lees Summit, MO USA.
[Morris, D. M.; Gemeinhardt, T. R.] US Army Corps Engineers, Missouri River Water Qual Program, Kansas City, MO 64106 USA.
RP Morris, DM (reprint author), US Army Corps Engineers, Missouri River Water Qual Program, Kansas City, MO 64106 USA.
EM dane.m.morris@usace.army.mil
FU USACE, Kansas City District
FX This study was conducted with a financial support from the USACE, Kansas
City District. We would like to thank the Kansas City District Drill
Crew and Palmerton & Parrish, Inc. for their valuable help in collecting
soil samples. For GIS analyses, orthophotograph analyses, and
bathymetric survey data collection, the authors gratefully acknowledge
Tracy Brown, Lisa Hook, Shahrzad Jalili, and Ben Johnson (USACE).
Finally, for providing a technical review of the report, the authors
gratefully acknowledge Chance Bitner (USACE) and Kyle Juracek (USGS).
Reference to trade names does not imply endorsement by the US
Government. All product names and trademarks cited are the property of
their respective owners. The findings of this report are not to be
construed as an official Department of Army position unless so
designated by other authorized documents.
NR 44
TC 1
Z9 1
U1 3
U2 10
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1535-1459
EI 1535-1467
J9 RIVER RES APPL
JI River Res. Appl.
PD MAR
PY 2015
VL 31
IS 3
BP 323
EP 334
DI 10.1002/rra.2742
PG 12
WC Environmental Sciences; Water Resources
SC Environmental Sciences & Ecology; Water Resources
GA CD4LQ
UT WOS:000351054600006
ER
PT J
AU Hickey, JT
Newbold, SJ
Warner, AT
AF Hickey, J. T.
Newbold, S. J.
Warner, A. T.
TI HEC-RPT - SOFTWARE FOR FACILITATING DEVELOPMENT OF RIVER MANAGEMENT
ALTERNATIVES
SO RIVER RESEARCH AND APPLICATIONS
LA English
DT Article
DE HEC-RPT; Regime Prescription Tool; water resources planning;
collaborative modelling; environmental flows
ID WATER MANAGEMENT; SYSTEM
AB The Regime Prescription Tool (RPT) is a software program designed to help groups of scientists, engineers, and water managers access hydrologic data and draft flow recommendations while formulating different ways to manage rivers. It is a communications tool and contributes in the early stages of planning by formalizing ideas and expert knowledge into a structure easily visualized and considered in more detailed analytical tools. Applying RPT helps organize and focus group conversations that seek to create consensus-based alternatives for water management. This paper introduces the software and its role in water resources planning. An RPT application used in the definition of environmental flows for the McKenzie River, Oregon, USA, is presented. Copyright (c) 2014 John Wiley & Sons, Ltd.
C1 [Hickey, J. T.] USACE, Hydrol Engn Ctr, Inst Water Resources, Davis, CA 95616 USA.
[Newbold, S. J.] Resource Management Associates, Fairfield, CA USA.
[Warner, A. T.] Nature Conservancy, North Amer Freshwater Program, University Pk, PA USA.
RP Hickey, JT (reprint author), USACE, Hydrol Engn Ctr, Inst Water Resources, 609 Second St, Davis, CA 95616 USA.
EM john.t.hickey@usace.army.mil
FU cooperative of Corps District offices
FX Development of RPT was initially partnered by The Nature Conservancy,
and the Portland District and HEC of the US Army Corps of Engineers.
Mary Karen Scullion, Brad Bird, and Bruce Duffe, Portland District, were
instrumental in commencing this project. Since then, RPT has been
supported through a model maintenance programme sponsored by a
cooperative of Corps District offices. The Nature Conservancy
(www.nature.org) contributed to design and has led several applications
of RPT. Software coding was performed by Resource Management Associates,
Inc. (www.rmanet.com). The McKenzie River Environmental Flows Workshop
was led by Leslie Bach, The Nature Conservancy, Karl Morgenstern, Eugene
Water and Electric Board, and John Risley, USGS. Application of RPT was
prepared and conducted by John Risley.
NR 32
TC 1
Z9 1
U1 0
U2 4
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1535-1459
EI 1535-1467
J9 RIVER RES APPL
JI River Res. Appl.
PD MAR
PY 2015
VL 31
IS 3
BP 392
EP 401
DI 10.1002/rra.2745
PG 10
WC Environmental Sciences; Water Resources
SC Environmental Sciences & Ecology; Water Resources
GA CD4LQ
UT WOS:000351054600011
ER
PT J
AU Svensson, SP
Crowne, FJ
Hier, HS
Sarney, WL
Beck, WA
Lin, Y
Donetsky, D
Suchalkin, S
Belenky, G
AF Svensson, S. P.
Crowne, F. J.
Hier, H. S.
Sarney, W. L.
Beck, W. A.
Lin, Y.
Donetsky, D.
Suchalkin, S.
Belenky, G.
TI Background and interface electron populations in InAs0.58Sb0.42
SO SEMICONDUCTOR SCIENCE AND TECHNOLOGY
LA English
DT Article
DE InAsSb; Hall-effect; doping
ID TRANSPORT-PROPERTIES; QUANTUM-WELLS; PHOTODIODES; SURFACES; DONORS
AB The unintentional background electron population and associated interface and surface conductivity in a heterostructure of InAs0.58Sb0.42 with a bandgap of 0.144 eV and AlInSb was studied with multi-carrier Hall-effect analysis. A free electron bulk concentration at 77 K was found with a density of 2.4 x 10(15) cm(-3) and mobility of 140 000 cm(2) V(-1)s(-1). A surface electron accumulation layer was observed with a density of 5.5 x 10(11) cm(-2) and mobility of 4500 cm(2)V(-1)s(-1) that is consistent with predictions of surface Fermi level pinning. Another accumulation layer was identified at the interface with the AlInSb of 4 x 10(11) cm(-2) with a mobility of 37 000 cm(2) V(-1)s(-1). The origin of the defects and the implications for device structures are discussed.
C1 [Svensson, S. P.; Crowne, F. J.; Hier, H. S.; Sarney, W. L.; Beck, W. A.] US Army, Res Lab, Adelphi, MD 20783 USA.
[Lin, Y.; Donetsky, D.; Suchalkin, S.; Belenky, G.] SUNY Stony Brook, Dept Elect & Comp Engn, Stony Brook, NY 11794 USA.
RP Svensson, SP (reprint author), US Army, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA.
EM stefan.p.svensson.civ@mail.mil
OI LIN, YOUXI/0000-0002-9092-2302
FU US Army Research Office [W911NF1220057]; US National Science Foundation
[DMR1160843]
FX Part of this work was supported by the US Army Research Office through
award W911NF1220057 and by the US National Science Foundation through
grant DMR1160843.
NR 26
TC 4
Z9 4
U1 5
U2 19
PU IOP PUBLISHING LTD
PI BRISTOL
PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND
SN 0268-1242
EI 1361-6641
J9 SEMICOND SCI TECH
JI Semicond. Sci. Technol.
PD MAR
PY 2015
VL 30
IS 3
AR 035018
DI 10.1088/0268-1242/30/3/035018
PG 5
WC Engineering, Electrical & Electronic; Materials Science,
Multidisciplinary; Physics, Condensed Matter
SC Engineering; Materials Science; Physics
GA CC8PU
UT WOS:000350631400019
ER
PT J
AU Srinivas, U
Nasrabadi, NM
Monga, V
AF Srinivas, Umamahesh
Nasrabadi, Nasser M.
Monga, Vishal
TI Graph-Based Sensor Fusion for Classification of Transient Acoustic
Signals
SO IEEE TRANSACTIONS ON CYBERNETICS
LA English
DT Article
DE Acoustic signal classification; discriminative graphs; multiple
measurements; symbolic features
ID SUPPORT VECTOR MACHINES; MULTISENSOR DATA FUSION; DISTRIBUTIONS;
RECOGNITION; RETRIEVAL; NETWORKS; MODELS
AB Advances in acoustic sensing have enabled the simultaneous acquisition of multiple measurements of the same physical event via co-located acoustic sensors. We exploit the inherent correlation among such multiple measurements for acoustic signal classification, to identify the launch/impact of munition (i.e., rockets, mortars). Specifically, we propose a probabilistic graphical model framework that can explicitly learn the class conditional correlations between the cepstral features extracted from these different measurements. Additionally, we employ symbolic dynamic filtering-based features, which offer improvements over the traditional cepstral features in terms of robustness to signal distortions. Experiments on real acoustic data sets show that our proposed algorithm outperforms conventional classifiers as well as the recently proposed joint sparsity models for multisensor acoustic classification. Additionally our proposed algorithm is less sensitive to insufficiency in training samples compared to competing approaches.
C1 [Srinivas, Umamahesh; Monga, Vishal] Penn State Univ, Dept Elect Engn, University Pk, PA 16802 USA.
[Nasrabadi, Nasser M.] US Army Res Lab, Adelphi, MD 20783 USA.
RP Srinivas, U (reprint author), Penn State Univ, Dept Elect Engn, University Pk, PA 16802 USA.
EM usrinivas@ieee.org; vmonga@engr.psu.edu
FU Office of Naval Research [N00014-12-1-0765]
FX The work of U. Srinivas and V. Monga was supported by the Office of
Naval Research under Grant N00014-12-1-0765.
NR 39
TC 1
Z9 1
U1 0
U2 5
PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
PI PISCATAWAY
PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA
SN 2168-2267
EI 2168-2275
J9 IEEE T CYBERNETICS
JI IEEE T. Cybern.
PD MAR
PY 2015
VL 45
IS 3
BP 576
EP 587
DI 10.1109/TCYB.2014.2331284
PG 12
WC Computer Science, Artificial Intelligence; Computer Science, Cybernetics
SC Computer Science
GA CC2AN
UT WOS:000350146900019
PM 25014986
ER
PT J
AU Darwish, A
Bayba, AJ
Hung, HA
AF Darwish, Ali
Bayba, Andrew J.
Hung, Hingloi Alfred
TI Channel Temperature Analysis of GaN HEMTs With Nonlinear Thermal
Conductivity
SO IEEE TRANSACTIONS ON ELECTRON DEVICES
LA English
DT Article
DE AlGaN; gallium nitride (GaN); HEMT; nonlinear thermal conductivity;
reliability; thermal resistance; wide bandgap
ID ALGAN/GAN HEMTS; BOUNDARY RESISTANCE; THIN-FILMS; DEVICES; TRANSISTORS;
MICROSCOPY; SUBSTRATE; GANHEMTS; CRYSTALS
AB This paper presents an enhanced, closed-form expression for the thermal resistance, and thus, the channel temperature of AlGaN/gallium nitride (GaN) HEMTs, including the effect of the temperature-dependent thermal conductivity of GaN and SiC or Si substrates. In addition, the expression accounts for temperature increase across the die-attach. The model's validity is verified by comparing it with experimental observations. The model results also compare favorably with those from finite-element numerical simulations across the various device geometric and material parameters. The model provides a more accurate channel temperature than that from a constant thermal conductivity assumption; this is particularly significant for GaN/Si HEMTs where the temperature rise is higher than in GaN/SiC. The model is especially useful for device and monolithic microwave integrated circuit designers in the thermal assessment of their device design iterations against required performance for their specific applications.
C1 [Darwish, Ali; Bayba, Andrew J.; Hung, Hingloi Alfred] US Army Res Lab, Adelphi, MD 20783 USA.
RP Darwish, A (reprint author), US Army Res Lab, Adelphi, MD 20783 USA.
EM darwish@alum.mit.edu; andrew.j.bayba.civ@mail.mil; hahung@alum.mit.edu
NR 37
TC 9
Z9 9
U1 7
U2 45
PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
PI PISCATAWAY
PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA
SN 0018-9383
EI 1557-9646
J9 IEEE T ELECTRON DEV
JI IEEE Trans. Electron Devices
PD MAR
PY 2015
VL 62
IS 3
BP 840
EP 846
DI 10.1109/TED.2015.2396035
PG 7
WC Engineering, Electrical & Electronic; Physics, Applied
SC Engineering; Physics
GA CC4OF
UT WOS:000350332000023
ER
PT J
AU D'Onofrio, MJ
Schlett, CD
Millar, EV
Cui, T
Lanier, JB
Law, NN
Tribble, DR
Ellis, MW
AF D'Onofrio, Michael J.
Schlett, Carey D.
Millar, Eugene V.
Cui, Tianyuan
Lanier, Jeffrey B.
Law, Natasha N.
Tribble, David R.
Ellis, Michael W.
TI Reduction in Acute Gastroenteritis among Military Trainees: Secondary
Effects of a Hygiene-based Cluster-Randomized Trial for Skin and Soft
Tissue Infection Prevention
SO INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY
LA English
DT Editorial Material
C1 [D'Onofrio, Michael J.] Walter Reed Army Inst Res, Silver Spring, MD USA.
[Schlett, Carey D.; Millar, Eugene V.; Cui, Tianyuan; Law, Natasha N.; Tribble, David R.] Uniformed Serv Univ Hlth Sci, Infect Dis Clin Res Program, Bethesda, MD 20814 USA.
[Lanier, Jeffrey B.] Martin Army Community Hosp, Ft Benning, GA USA.
[Ellis, Michael W.] Uniformed Serv Univ Hlth Sci, Dept Med, Bethesda, MD 20814 USA.
RP Millar, EV (reprint author), Uniformed Serv Univ Hlth Sci, Infect Dis Clin Res Program, Dept Prevent Med & Biometr, 11300 Rockville Pike,Suite 1211, Rockville, MD 20852 USA.
EM emillar@idcrp.org
FU NIAID NIH HHS [Y1-AI-5072]]
NR 6
TC 1
Z9 1
U1 0
U2 0
PU CAMBRIDGE UNIV PRESS
PI NEW YORK
PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA
SN 0899-823X
EI 1559-6834
J9 INFECT CONT HOSP EP
JI Infect. Control Hosp. Epidemiol.
PD MAR
PY 2015
VL 36
IS 3
BP 358
EP 360
DI 10.1017/ice.2014.65
PG 3
WC Public, Environmental & Occupational Health; Infectious Diseases
SC Public, Environmental & Occupational Health; Infectious Diseases
GA CC2DW
UT WOS:000350156300019
PM 25695181
ER
PT J
AU Kittikraisak, W
Suntarattiwong, P
Levy, J
Fernandez, S
Dawood, FS
Olsen, SJ
Chotpitayasunondh, T
AF Kittikraisak, Wanitchaya
Suntarattiwong, Piyarat
Levy, Jens
Fernandez, Stefan
Dawood, Fatimah S.
Olsen, Sonja J.
Chotpitayasunondh, Tawee
TI Influenza vaccination coverage and effectiveness in young children in
Thailand, 2011-2013
SO INFLUENZA AND OTHER RESPIRATORY VIRUSES
LA English
DT Article
DE Influenza; vaccination; coverage; effectiveness; Thailand; children
ID AGED 6-23 MONTHS; LABORATORY-CONFIRMED INFLUENZA; UNITED-STATES; SEASON;
IMMUNIZATION; EFFICACY; HOSPITALIZATION; OUTPATIENT; COMMUNITY; VACCINES
AB BackgroundSince 2009, Thailand has recommended influenza vaccine for children aged 6months through 2years, but no estimates of influenza vaccine coverage or effectiveness are available for this target group.
MethodsDuring August 2011-May 2013, high-risk and healthy children aged 36months were enrolled in a 2-year prospective cohort study. Parents were contacted weekly about acute respiratory illness (ARI) in their child. Ill children had combined nasal and throat swabs tested for influenza viruses by real-time reverse transcription-polymerase chain reaction. Influenza vaccination status was verified with vaccination cards. The Cox proportional hazards approach was used to estimate hazard ratios. Vaccine effectiveness (VE) was estimated as 100% x (1-hazard ratio).
ResultsDuring 2011-2013, 968 children were enrolled (median age, 103months); 948 (979%) had a vaccination record and were included. Of these, 394 (416%) had 1 medical conditions. Vaccination coverage for the 2011-2012 and 2012-2013 seasons was 293% (93/317) and 300% (197/656), respectively. In 2011-2012, there were 213 ARI episodes, of which 10 (46%) were influenza positive (23 per 1000 vaccinated and 38 per 1000 unvaccinated child-weeks). The VE was 55% (95% confidence interval [CI], -72, 88). In 2012-2013, there were 846 ARIs, of which 52 (62%) were influenza positive (18 per 1000 vaccinated and 45 per 1000 unvaccinated child-weeks). The VE was 64% (CI, 13%, 85%).
ConclusionInfluenza vaccination coverage among young children in Thailand was low, although vaccination was moderately effective. Continued efforts are needed to increase influenza vaccination coverage and evaluate VE among young children in Thailand.
C1 [Kittikraisak, Wanitchaya; Levy, Jens; Olsen, Sonja J.] Thailand Minist Publ Hlth US Ctr Dis Control & Pr, Influenza Program, Nonthaburi, Thailand.
[Suntarattiwong, Piyarat; Chotpitayasunondh, Tawee] Minist Publ Hlth, Queen Sirikit Natl Inst Child Hlth, Bangkok, Thailand.
[Fernandez, Stefan] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand.
[Dawood, Fatimah S.; Olsen, Sonja J.] US Ctr Dis Control & Prevent, Influenza Div, Atlanta, GA USA.
RP Kittikraisak, W (reprint author), Minist Publ Hlth, Thailand MOPH US CDC Collaborat, DDC Bldg 7,Tiwanon Rd, Nonthaburi 11000, Thailand.
EM glr9@cdc.gov
FU U.S. Centers for Disease Control and Prevention [5U01GH000152]
FX This project was funded by U.S. Centers for Disease Control and
Prevention through cooperative agreement 5U01GH000152. All authors have
no financial relationships relevant to this article to disclose.
NR 43
TC 6
Z9 6
U1 2
U2 3
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1750-2640
EI 1750-2659
J9 INFLUENZA OTHER RESP
JI Influenza Other Respir. Viruses
PD MAR
PY 2015
VL 9
IS 2
BP 85
EP 93
DI 10.1111/irv.12302
PG 9
WC Infectious Diseases; Virology
SC Infectious Diseases; Virology
GA CC4TQ
UT WOS:000350347100005
PM 25557920
ER
PT J
AU Ivany, CG
Hoge, CW
AF Ivany, Christopher G.
Hoge, Charles W.
TI Adverse Childhood Experiences and Military Service
SO JAMA PSYCHIATRY
LA English
DT Letter
C1 [Ivany, Christopher G.; Hoge, Charles W.] Behav Hlth Div, Off Army Surg Gen, Falls Church, VA USA.
[Hoge, Charles W.] Walter Reed Army Inst Res, Ctr Psychiat & Neurosci, Silver Spring, MD 20910 USA.
RP Hoge, CW (reprint author), Walter Reed Army Inst Res, Ctr Psychiat & Neurosci, 503 Robert Grant Ave, Silver Spring, MD 20910 USA.
EM charles.hoge@us.army.mil
NR 5
TC 2
Z9 2
U1 0
U2 1
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA
SN 2168-622X
EI 2168-6238
J9 JAMA PSYCHIAT
JI JAMA Psychiatry
PD MAR
PY 2015
VL 72
IS 3
BP 296
EP 296
PG 1
WC Psychiatry
SC Psychiatry
GA CC7UJ
UT WOS:000350573600015
PM 25738692
ER
PT J
AU Jelis, E
Clemente, M
Kerwien, S
Ravindra, NM
Hespos, MR
AF Jelis, Elias
Clemente, Matthew
Kerwien, Stacey
Ravindra, Nuggehalli M.
Hespos, Michael R.
TI Metallurgical and Mechanical Evaluation of 4340 Steel Produced by Direct
Metal Laser Sintering
SO JOM
LA English
DT Article
ID MICROSTRUCTURAL FEATURES; FATIGUE BEHAVIOR; POWDERS; ALLOY
AB Direct metal laser sintering (DMLS) was used to produce high-strength low-alloy 4340 steel specimens. Mechanical and metallurgical analyses were performed on the specimens to determine the samples with the highest strengths and the least porosity. The optimal process parameters were thus defined based on the corresponding experimental conditions. Additionally, the effects of fabricating specimens with both virgin and recycled powders were studied. Scanning electron microscopy and electron-dispersive spectroscopy were performed on both types of powders to determine the starting morphology and composition. The initial tensile results are promising, suggesting that DMLS can produce specimens equal in strength to wrought materials. However, there is evidence of cracking on several of the heat-treated tensile specimens that is unexplained. Several theories point to disturbances in the build chamber environment that went undetected while the specimens were being fabricated.
C1 [Jelis, Elias; Clemente, Matthew; Kerwien, Stacey; Hespos, Michael R.] US Army ARDEC, Picatinny Arsenal, NJ 07806 USA.
[Jelis, Elias; Ravindra, Nuggehalli M.] New Jersey Inst Technol, Interdisciplinary Program Mat Sci & Engn, Newark, NJ 07102 USA.
RP Jelis, E (reprint author), US Army ARDEC, Picatinny Arsenal, NJ 07806 USA.
EM nmravindra@gmail.com
FU SMART Fellowship by US Department of Defense
FX Elias Jelis acknowledges with thanks the award of the SMART Fellowship
by the US Department of Defense.
NR 28
TC 5
Z9 5
U1 4
U2 16
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1047-4838
EI 1543-1851
J9 JOM-US
JI JOM
PD MAR
PY 2015
VL 67
IS 3
BP 582
EP 589
DI 10.1007/s11837-014-1273-8
PG 8
WC Materials Science, Multidisciplinary; Metallurgy & Metallurgical
Engineering; Mineralogy; Mining & Mineral Processing
SC Materials Science; Metallurgy & Metallurgical Engineering; Mineralogy;
Mining & Mineral Processing
GA CC3ID
UT WOS:000350239400015
ER
PT J
AU Housman, KJ
Swift, AT
Oyler, JM
AF Housman, Kathleen J.
Swift, Austin T.
Oyler, Jonathan M.
TI Fragmentation Pathways and Structural Characterization of 14 Nerve Agent
Compounds by Electrospray Ionization Tandem Mass Spectrometry
SO JOURNAL OF ANALYTICAL TOXICOLOGY
LA English
DT Article
ID CHEMICAL WARFARE AGENTS; LIQUID-CHROMATOGRAPHY; ION-TRAP; HYDROLYSIS
PRODUCTS; VX; VERIFICATION; SOIL; SARIN; PHASE; SOMAN
AB Organophosphate nerve agents (OPNAs) are some of the most widely used and proliferated chemical warfare agents. As evidenced by recent events in Syria, these compounds remain a serious military and terrorist threat to human health because of their toxicity and the ease with which they can be used, produced and stored. There are over 2,000 known, scheduled compounds derived from common parent structures with many more possible. To address medical, forensic, attribution, remediation and other requirements, laboratory systems have been established to provide the capability to analyze 'unknown' samples for the presence of these compounds. Liquid chromatography/mass spectrometric methods have been validated and are routinely used in the analysis of samples for a very limited number of these compounds, but limited data exist characterizing the electrospray ionization (ESI) and mass spectrometric fragmentation pathways of the compound families. This report describes results from direct infusion ESI/MS, ESI/MS2 and ESI/MS3 analysis of 14 G and V agents, the major OPNA families, using an AB Sciex 4000 QTrap. Using a range of conditions, spectra were acquired and characteristic fragments identified. The results demonstrated that the reproducible and predictable fragmentation of these compounds by ESI/MS, ESI/MS2 and ESI/MS3 can be used to describe systematic fragmentation pathways specific to compound structural class. These fragmentation pathways, in turn, may be useful as a predictive tool in the analysis of samples by screening and confirmatory laboratories to identify related compounds for which authentic standards are not readily available.
C1 [Housman, Kathleen J.; Swift, Austin T.; Oyler, Jonathan M.] US Army, Med Res Inst Chem Def, Aberdeen Proving Ground, MD 21010 USA.
RP Oyler, JM (reprint author), US Army, Med Res Inst Chem Def, 3100 Ricketts Point Rd, Aberdeen Proving Ground, MD 21010 USA.
EM jonathan.m.oyler.civ@mail.mil
FU Defense Threat Reduction Agency-Joint Science and Technology Office,
Medical ST Division
FX The views expressed in this article are those of the author(s) and do
not reflect the official policy of the Department of Army, Department of
Defense or the U.S. Government. This research was supported by the
Defense Threat Reduction Agency-Joint Science and Technology Office,
Medical S&T Division.
NR 23
TC 3
Z9 3
U1 3
U2 44
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0146-4760
EI 1945-2403
J9 J ANAL TOXICOL
JI J. Anal. Toxicol.
PD MAR
PY 2015
VL 39
IS 2
BP 96
EP 105
DI 10.1093/jat/bku135
PG 10
WC Chemistry, Analytical; Toxicology
SC Chemistry; Toxicology
GA CC3BL
UT WOS:000350219100003
PM 25519457
ER
PT J
AU Chan, RK
Aden, J
Wu, J
Hale, RG
Renz, EM
Wolf, SE
AF Chan, Rodney K.
Aden, James
Wu, Jesse
Hale, Robert G.
Renz, Evan M.
Wolf, Steven E.
TI Operative Utilization Following Severe Combat-Related Burns
SO JOURNAL OF BURN CARE & RESEARCH
LA English
DT Article
ID SKIN; SURGEONS; WAR
AB The goal of burn surgical therapy is to minimize mortality and to return survivors to their preinjury state. Prompt removal of the burn eschar, early durable coverage, and late corrections of functional deformities are the basic surgical principles. The operative burden, while presumed to be substantial and significant, is neither well described nor quantified. The burn registry at the U.S. Institute of Surgical Research Burn Center was queried from March 2003 to August 2011 for all active duty burn admissions; active duty subjects were chosen to eliminate subject follow-up as a significant variable. Subject demographics including age, sex, branch of service, injury type, injury severity score, transfusion, allograft use, length of stay, mechanism of injury, and survival were tabulated as were their percentage TBSA, specific body region involvement, and nature and dates of operations performed. Univariate analysis and multiple logistic regressions were performed to determine independent factors which predict early and late operative burden. In the 8-year study period, 864 active duty patients were admitted to the burn center. Among them, 569 (66%) were operative in nature. The operations that were performed during acute hospitalization were 62%, while the remaining 38% were performed following discharge. A linear relationship exists between TBSA and the number of acute operations with an average of one acute operation required per 5% TBSA. No direct relationships however were found between TBSA and the number of reconstructive operations. Based on multiple logistic regression, battle vs nonbattle (odds ratio [OR], 0.559; 95% confidence interval [CI], 0.298-1.050; P = .0706), injury severity score (OR, 1.021; 95% CI, 1.003-1.039; P = .0222), intensive care unit length of stay (OR, 1.076; 95% CI, 1.053-1.099; P .0001), allograft use (OR, 2.610; 95% CI, 1.472-4.628; P = .0010), and TBSA of the trunk (OR, 0.982; 95% CI, 0.965-1.000; P = .0439) (but not overall TBSA) were associated with a high acute operative burden. Battle vs nonbattle (OR, 0.546; 95% CI, 0.360-0.829; P = .0045), and TBSA of the upper extremities (OR, 1.008; 95% CI, 1.002-1.013; P = .0042) were noted to be significant variables in predicting late reconstruction operations. The operative burden of burn, not previously well characterized, consists of operations performed during as well as after the initial hospitalization. While injury severity and truncal involvement are significant determinants of acute surgical therapy, the presence of upper extremity burns is a significant determinant of reconstruction following discharge.
C1 [Chan, Rodney K.; Aden, James; Renz, Evan M.] US Army Inst Surg Res, Ft Sam Houston, TX 78234 USA.
[Chan, Rodney K.; Wu, Jesse; Hale, Robert G.] US Army Inst Surg Res, Dent & Trauma Res Detachment, Ft Sam Houston, TX USA.
[Wolf, Steven E.] Univ Texas SW Med Ctr Dallas, Burn Ctr, Dallas, TX 75390 USA.
RP Chan, RK (reprint author), US Army Inst Surg Res, Ft Sam Houston, TX 78234 USA.
NR 20
TC 1
Z9 1
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1559-047X
EI 1559-0488
J9 J BURN CARE RES
JI J. Burn Care Res.
PD MAR-APR
PY 2015
VL 36
IS 2
BP 287
EP 296
DI 10.1097/BCR.0000000000000132
PG 10
WC Emergency Medicine; Dermatology; Surgery
SC Emergency Medicine; Dermatology; Surgery
GA CC5JO
UT WOS:000350395100024
PM 25102231
ER
PT J
AU Hutchenson, KD
Conner, RB
Johnson, LB
Bennett, HH
Simms, JE
Yule, DE
AF Hutchenson, Kevin D.
Conner, Ray B.
Johnson, Lars B.
Bennett, Hollis H., Jr.
Simms, Janet E.
Yule, Don E.
TI Evaluation and Current Results of the Seismic Acoustic Impact Monitoring
Assessment (SAIMA) System
SO JOURNAL OF ENVIRONMENTAL AND ENGINEERING GEOPHYSICS
LA English
DT Article
AB For the past several years, Quantum Technology Sciences (QTSI) and U.S. Army Engineering Research and Development Center (ERDC) have been developing a system to actively sustain present and future artillery ranges at zero unexploded ordnance (UXO) gains. With the Department of Defense (DoD) using over two million high-explosive (HE) munitions per year with a significant fraction as UXO, reducing costly range remediation and environmental restoration efforts will offer significant savings. The developed Seismic Acoustic Impact Monitoring Assessment (SAIMA) system is not designed for past ranges, but as a complementary technology to detect, locate within two meters, and classify UXO in near realtime to aid existing cleanup technologies.
Feasibility and descriptions of system components have been previously provided (VanDeMark et al., 2009, 2010, 2013). The current system is composed of multiple buried seismic arrays encircling a mortar or artillery impact area, communications from the arrays to a central processing station, and a processing unit that employs an algorithm suite based in the seismology and statistical analysis disciplines to detect, locate, and classify the HE or UXO impact.
Recent deployments of the SAIMA system have demonstrated hardware maturity and algorithm refinements to nearly enable the goal of locations within two meters. A field deployment at Ft. Sill, Oklahoma, in June 2012 demonstrated acoustic locations at a large range (QTSI, 2012). Subsequent systems tests with five arrays using a synthetic UXO source (kinetic source only; no acoustic phases) on a small field (80 m by 80 m) resolved locations within 0.5 m of ground truth with coverage ellipses at 0.1 m(2) (time and azimuth). On a small mortar field, approximately 365 m by 480 m, simulated UXO (inert rounds) were located within an average mislocation distance of 4.1 m and confidence ellipses on the order of 5.8 m by 3.8 m. Scheduled field testing in the near future will validate the system.
C1 [Hutchenson, Kevin D.; Conner, Ray B.; Johnson, Lars B.] Quantum Technol Sci, Cocoa Beach, FL 32931 USA.
[Bennett, Hollis H., Jr.; Simms, Janet E.; Yule, Don E.] US Army, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA.
RP Hutchenson, KD (reprint author), Quantum Technol Sci, 1980 N Atlantic Ave,Suite 201, Cocoa Beach, FL 32931 USA.
NR 12
TC 0
Z9 0
U1 1
U2 4
PU ENVIRONMENTAL ENGINEERING GEOPHYSICAL SOC
PI DENVER
PA 1720 SOUTH BELLAIRE, STE 110, DENVER, CO 80222-433 USA
SN 1083-1363
J9 J ENVIRON ENG GEOPH
JI J. Environ. Eng. Geophys.
PD MAR
PY 2015
VL 20
IS 1
BP 89
EP 100
DI 10.2113/JEEG20.1.89
PG 12
WC Geochemistry & Geophysics; Engineering, Geological
SC Geochemistry & Geophysics; Engineering
GA CC8IQ
UT WOS:000350612100008
ER
PT J
AU Takala-Harrison, S
Jacob, CG
Arze, C
Cummings, MP
Silva, JC
Dondorp, AM
Fukuda, MM
Hien, TT
Mayxay, M
Noedl, H
Nosten, F
Kyaw, MP
Nhien, NTT
Imwong, M
Bethell, D
Se, Y
Lon, C
Tyner, SD
Saunders, DL
Ariey, F
Mercereau-Puijalon, O
Menard, D
Newton, PN
Khanthavong, M
Hongvanthong, B
Starzengruber, P
Fuehrer, HP
Swoboda, P
Khan, WA
Phyo, AP
Nyunt, MM
Nyunt, MH
Brown, TS
Adams, M
Pepin, CS
Bailey, J
Tan, JC
Ferdig, MT
Clark, TG
Miotto, O
MacInnis, B
Kwiatkowski, DP
White, NJ
Ringwald, P
Plowe, CV
AF Takala-Harrison, Shannon
Jacob, Christopher G.
Arze, Cesar
Cummings, Michael P.
Silva, Joana C.
Dondorp, Arjen M.
Fukuda, Mark M.
Tran Tinh Hien
Mayxay, Mayfong
Noedl, Harald
Nosten, Francois
Kyaw, Myat P.
Nguyen Thanh Thuy Nhien
Imwong, Mallika
Bethell, Delia
Se, Youry
Lon, Chanthap
Tyner, Stuart D.
Saunders, David L.
Ariey, Frederic
Mercereau-Puijalon, Odile
Menard, Didier
Newton, Paul N.
Khanthavong, Maniphone
Hongvanthong, Bouasy
Starzengruber, Peter
Fuehrer, Hans-Peter
Swoboda, Paul
Khan, Wasif A.
Phyo, Aung Pyae
Nyunt, Myaing M.
Nyunt, Myat H.
Brown, Tyler S.
Adams, Matthew
Pepin, Christopher S.
Bailey, Jason
Tan, John C.
Ferdig, Michael T.
Clark, Taane G.
Miotto, Olivo
MacInnis, Bronwyn
Kwiatkowski, Dominic P.
White, Nicholas J.
Ringwald, Pascal
Plowe, Christopher V.
TI Independent Emergence of Artemisinin Resistance Mutations Among
Plasmodium falciparum in Southeast Asia
SO JOURNAL OF INFECTIOUS DISEASES
LA English
DT Article
DE malaria; artemisinin resistance; Southeast Asia; Plasmodium falciparum;
kelch
ID PARASITE CLEARANCE; WESTERN CAMBODIA; MALARIA; ASSOCIATION; PROVINCE;
PYRIMETHAMINE; NETWORKS; SPREAD
AB Background. The emergence of artemisinin-resistant Plasmodium falciparum in Southeast Asia threatens malaria treatment efficacy. Mutations in a kelch protein encoded on P. falciparum chromosome 13 (K13) have been associated with resistance in vitro and in field samples from Cambodia.
Methods. P. falciparum infections from artesunate efficacy trials in Bangladesh, Cambodia, Laos, Myanmar, and Vietnam were genotyped at 33 716 genome-wide single-nucleotide polymorphisms (SNPs). Linear mixed models were used to test associations between parasite genotypes and parasite clearance half-lives following artesunate treatment. K13 mutations were tested for association with artemisinin resistance, and extended haplotypes on chromosome 13 were examined to determine whether mutations arose focally and spread or whether they emerged independently.
Results. The presence of nonreference K13 alleles was associated with prolonged parasite clearance half-life (P = 1.97 x 10(-12)). Parasites with a mutation in any of the K13 kelch domains displayed longer parasite clearance half-lives than parasites with wild-type alleles. Haplotype analysis revealed both population-specific emergence of mutations and independent emergence of the same mutation in different geographic areas.
Conclusions. K13 appears to be a major determinant of artemisinin resistance throughout Southeast Asia. While we found some evidence of spreading resistance, there was no evidence of resistance moving westward from Cambodia into Myanmar.
C1 [Takala-Harrison, Shannon; Jacob, Christopher G.; Nyunt, Myaing M.; Brown, Tyler S.; Adams, Matthew; Pepin, Christopher S.; Bailey, Jason; Plowe, Christopher V.] Univ Maryland, Sch Med, Ctr Vaccine Dev, Howard Hughes Med Inst, Baltimore, MD 21201 USA.
[Arze, Cesar; Silva, Joana C.] Univ Maryland, Sch Med, Inst Genome Sci, Baltimore, MD 21201 USA.
[Cummings, Michael P.] Univ Maryland, Ctr Bioinformat & Computat Biol, College Pk, MD 20742 USA.
[Tan, John C.] Roche NimbleGen, Res & Dev, Madison, WI USA.
[Ferdig, Michael T.] Univ Notre Dame, Dept Biol Sci, Eck Inst Global Hlth, Indiana, PA USA.
[Dondorp, Arjen M.; Nosten, Francois; Phyo, Aung Pyae; Miotto, Olivo; White, Nicholas J.] Mahidol Univ, Fac Trop Med, Mahidol Oxford Trop Med Res Unit, Bangkok, Thailand.
[Imwong, Mallika] Mahidol Univ, Fac Trop Med, Dept Mol Trop Med & Genet, Bangkok, Thailand.
[Fukuda, Mark M.; Bethell, Delia; Tyner, Stuart D.; Saunders, David L.] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand.
[Phyo, Aung Pyae] Mahidol Univ, Fac Trop Med, Shoklo Malaria Res Unit, Mae Sot, Thailand.
[Phyo, Aung Pyae] Mahidol Univ, Fac Trop Med, Mahidol Oxford Trop Med Res Unit, Mae Sot, Thailand.
[Tran Tinh Hien; Nguyen Thanh Thuy Nhien] Oxford Univ Clin Res Unit, Ctr Trop Med, Ho Chi Minh City, Vietnam.
[Mayxay, Mayfong; Newton, Paul N.] Mahosot Hosp, Microbiol Lab, Lao Oxford Mahosot Hosp Wellcome Trust Res Unit, Viangchan, Laos.
[Mayxay, Mayfong] Univ Hlth Sci, Fac Postgrad Studies, Viangchan, Laos.
[Mayxay, Mayfong] Univ Hlth Sci, Fac Postgrad Studies, Viangchan, Laos.
[Khanthavong, Maniphone; Hongvanthong, Bouasy] Ctr Malariol Parasitol & Entomol, Viangchan, Laos.
[Nosten, Francois; Newton, Paul N.] Univ Oxford, Nuffield Dept Med, Ctr Trop Med, Hinxton, Cambs, England.
[Miotto, Olivo; Kwiatkowski, Dominic P.] Univ Oxford, MRC Ctr Genom & Global Hlth, Hinxton, Cambs, England.
[Miotto, Olivo; Kwiatkowski, Dominic P.] Wellcome Trust Sanger Inst, Hinxton, Cambs, England.
[Clark, Taane G.] London Sch Hyg & Trop Med, Fac Epidemiol & Populat Hlth, Hinxton, Cambs, England.
[Clark, Taane G.] London Sch Hyg & Trop Med, Fac Infect & Trop Dis, Hinxton, Cambs, England.
[Miotto, Olivo; MacInnis, Bronwyn; Kwiatkowski, Dominic P.] Wellcome Trust Sanger Inst, Malaria Programme, Hinxton, Cambs, England.
[Noedl, Harald; Starzengruber, Peter; Fuehrer, Hans-Peter; Swoboda, Paul] Med Univ Vienna, Inst Specif Prophylaxis & Trop Med, Vienna, Austria.
[Kyaw, Myat P.; Nyunt, Myat H.] Dept Med Res Lower Myanmar, Yangon, Myanmar.
[Se, Youry; Lon, Chanthap] Armed Forces Res Inst Med Sci, Phnom Penh, Cambodia.
[Menard, Didier] Inst Pasteur Cambodge, Malaria Mol Epidemiol Unit, Phnom Penh, Cambodia.
[Ariey, Frederic] Inst Pasteur, Parasitol & Mycol Dept, GGIV Unit, Paris, France.
[Mercereau-Puijalon, Odile] Inst Pasteur, Parasite Mol Immunol Unit, Paris, France.
[Khan, Wasif A.] Int Ctr Diarrhoeal Dis Res, Dhaka 1000, Bangladesh.
[Ringwald, Pascal] WHO, Global Malaria Programme, Drug Resistance & Containment Unit, CH-1211 Geneva, Switzerland.
RP Takala-Harrison, S (reprint author), Univ Maryland, Sch Med, Ctr Vaccine Dev, 685 W Baltimore St,HSF1-480, Baltimore, MD 21201 USA.
EM stakala@medicine.umaryland.edu
RI Ferdig, Michael/C-6627-2016;
OI Miotto, Olivo/0000-0001-8060-6771; Kwiatkowski,
Dominic/0000-0002-5023-0176; Pyae Phyo, Aung/0000-0002-0383-9624
FU National Institute of Allergy and Infectious Diseases at the National
Institutes of Health [R01AI101713, U19AI10820]; World Health
Organization Global Malaria Programme; Doris Duke Charitable Foundation;
Howard Hughes Medical Institute; Wellcome Trust through Wellcome Trust
Sanger Institute [098051]; Wellcome Trust Centre for Human Genetics
[090532/Z/09/Z]; Resource Centre for Genomic Epidemiology of Malaria
[090770/Z/09/Z]; Wellcome Trust Mahidol University Oxford Tropical
Medicine Research Programme through Wellcome Trust; Centre for Genomics
and Global Health, through the Medical Research Council [G0600718]
FX This work was supported by the National Institute of Allergy and
Infectious Diseases at the National Institutes of Health (grant
R01AI101713 to S.T.-H. and grant U19AI10820.), the World Health
Organization Global Malaria Programme, the Doris Duke Charitable
Foundation, and the Howard Hughes Medical Institute, for genomic
analyses; the Wellcome Trust, through core funding of the Wellcome Trust
Sanger Institute (grant 098051), for sequencing analyses; the Wellcome
Trust Centre for Human Genetics (grant 090532/Z/09/Z), the Resource
Centre for Genomic Epidemiology of Malaria (grant 090770/Z/09/Z), and
the Wellcome Trust Mahidol University Oxford Tropical Medicine Research
Programme, through core funding from the Wellcome Trust; and the Centre
for Genomics and Global Health, through the Medical Research Council
(grant G0600718).
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PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0022-1899
EI 1537-6613
J9 J INFECT DIS
JI J. Infect. Dis.
PD MAR 1
PY 2015
VL 211
IS 5
BP 670
EP 679
DI 10.1093/infdis/jiu491
PG 10
WC Immunology; Infectious Diseases; Microbiology
SC Immunology; Infectious Diseases; Microbiology
GA CC3CL
UT WOS:000350222000002
PM 25180241
ER
PT J
AU Hruby, A
Hill, OT
Bulathsinhala, L
McKinnon, CJ
Montain, SJ
Young, AJ
Smith, TJ
AF Hruby, Adela
Hill, Owen T.
Bulathsinhala, Lakmini
McKinnon, Craig J.
Montain, Scott J.
Young, Andrew J.
Smith, Tracey J.
TI Trends in Overweight and Obesity in Soldiers Entering the US Army,
1989-2012
SO OBESITY
LA English
DT Article
ID WEIGHT CONTROL PROGRAM; RECRUIT MOTIVATION; MILITARY PERSONNEL;
UNITED-STATES; PREDICTORS; ENLISTMENT; ATTRITION; EPIDEMIC; STRENGTH
AB ObjectiveThe US Army recruits new soldiers from an increasingly obese civilian population. The change in weight status at entry into the Army between 1989 and 2012 and the demographic characteristics associated with overweight/obesity at entry were examined.
Methods1,741,070 unique individuals with complete sex, age, and anthropometric information contributed data to linear and logistic regressions examining time trends and associations between demographic characteristics and overweight/obesity.
ResultsThe prevalence of overweight (body mass index 25-<30 kg/m(2)) generally increased, from 25.8% (1989) to 37.2% (2012), peaking at 37.9% (2011). The prevalence of obesity (body mass index 30 kg/m(2)) also increased from 5.6% (1989) to 8.0% (2012), peaking at 12.3% (2009); 2005-2009 annual prevalence exceeded 10%. The most consistent demographic characteristics predicting overweight/obesity were male sex, older age, Hispanic or Asian/Pacific Island race/ethnicity, and being married. There were no distinct geographic trends.
ConclusionsThe US Army is not immune to the US obesity epidemic. Demographic characteristics associated with being overweight or obese should be considered when developing military-sponsored weight management programs for new soldiers.
C1 [Hruby, Adela; Montain, Scott J.; Young, Andrew J.; Smith, Tracey J.] US Army Res Inst Environm Med, Mil Nutr Div, Natick, MA 01760 USA.
[Hruby, Adela] Harvard Univ, Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA.
[Hill, Owen T.; Bulathsinhala, Lakmini; McKinnon, Craig J.] US Army Res Inst Environm Med, Mil Performance Div, Natick, MA USA.
[Hill, Owen T.] Ft Sam, Ctr Intrepid, Houston, TX USA.
RP Smith, TJ (reprint author), US Army Res Inst Environm Med, Mil Nutr Div, Natick, MA 01760 USA.
EM tracey.smith10.civ@mail.mil
FU Postgraduate Research Participation Program at the US Army Medical
Research Institute of Environmental Medicine
FX Dr. Hruby's contribution to this research was supported by an
appointment to the Postgraduate Research Participation Program at the US
Army Medical Research Institute of Environmental Medicine administered
by the Oak Ridge Institute for Science and Education through an
interagency agreement between the US Department of Energy and USAMRMC.
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PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1930-7381
EI 1930-739X
J9 OBESITY
JI Obesity
PD MAR
PY 2015
VL 23
IS 3
BP 662
EP 670
DI 10.1002/oby.20978
PG 9
WC Endocrinology & Metabolism; Nutrition & Dietetics
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA CC3LG
UT WOS:000350249700023
PM 25611465
ER
PT J
AU Stevens, JR
Pfannenstiel, TJ
AF Stevens, Jayne R.
Pfannenstiel, Travis J.
TI The Otologist's Tuning Fork Examination-Are You Striking It Correctly?
SO OTOLARYNGOLOGY-HEAD AND NECK SURGERY
LA English
DT Article
DE tuning fork; fundamental frequency; scanning vibrometer
AB Objective To determine if the manner in which a tuning fork is activated affects its vibrational response.
Study Design Diagnostic test assessment.
Setting Hearing Center of Excellence laboratory.
Subjects and Methods A Polytec OFV-5000 scanning vibrometer was used to measure the vibrational response of 256-Hz, 512-Hz, and 1024-Hz tuning forks after activation. The tuning forks were activated to varying intensities by striking 4 unique surfaces: the head, palm, a metal surface, and a wood table.
Results The fundamental frequency of the individual tuning fork was the dominant observed frequency in all testing scenarios. Additional nonharmonic frequencies were noted when the 256-Hz and 512-Hz tuning forks were struck off metal and wooden surfaces.
Conclusions Additional nonfundamental sound frequencies produced secondary to striking a tuning fork off a metal object or a wooden table could affect clinical tuning fork examination and complicate decisions regarding surgical candidacy.
C1 [Stevens, Jayne R.; Pfannenstiel, Travis J.] Brooke Army Med Ctr, Dept Otolaryngol Head & Neck Surg, San Antonio, TX USA.
RP Stevens, JR (reprint author), Brooke Army Med Ctr, Dept Otolaryngol Head & Neck Surg, MCHE SDT Otolaryngol, 3551 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA.
EM jayne.r.stevens@gmail.com
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PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 0194-5998
EI 1097-6817
J9 OTOLARYNG HEAD NECK
JI Otolaryngol. Head Neck Surg.
PD MAR
PY 2015
VL 152
IS 3
BP 477
EP 479
DI 10.1177/0194599814559697
PG 3
WC Otorhinolaryngology; Surgery
SC Otorhinolaryngology; Surgery
GA CC6LS
UT WOS:000350477100015
PM 25475500
ER
PT J
AU Sanders, ME
Peterson, JA
AF Sanders, Mary E.
Peterson, James A.
TI More Than a Name on the Wall Reflections on a Life Well Lived
SO ACSMS HEALTH & FITNESS JOURNAL
LA English
DT Editorial Material
C1 [Sanders, Mary E.] Univ Nevada, Sch Med, Div Wellness & Weight Management, Reno, NV 89557 USA.
[Sanders, Mary E.] Univ Nevada, Sch Publ Hlth, Reno, NV 89557 USA.
[Peterson, James A.] US Mil Acad, Phys Educ, West Point, NY USA.
RP Sanders, ME (reprint author), Univ Nevada, Sch Med, Div Wellness & Weight Management, Reno, NV 89557 USA.
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PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1091-5397
EI 1536-593X
J9 ACSMS HEALTH FIT J
JI ACSMS Health Fit. J.
PD MAR-APR
PY 2015
VL 19
IS 2
BP 27
EP 29
PG 3
WC Sport Sciences
SC Sport Sciences
GA CC2BN
UT WOS:000350149700007
ER
PT J
AU Tran, DD
Littlefield, PD
AF Tran, Daniel D.
Littlefield, Philip D.
TI Late presentation of subcutaneous emphysema and pneumomediastinum
following elective tonsillectomy
SO AMERICAN JOURNAL OF OTOLARYNGOLOGY
LA English
DT Article
ID ADENOTONSILLECTOMY; COMPLICATION
AB Subcutaneous emphysema and pneumomediastinum are rare complications following elective tonsillectomy. Although the mechanism of injury is unclear, air is thought to enter through either the buccopharyngeal mucosa during surgery or via alveolar rupture during positive pressure ventilation. Patients typically present immediately after surgery or upon anesthesia emergence. We describe a case of delayed pneumomediastinum in a 30 year-old female who presented 4 days after surgery. With only one other case described, we review the literature and remind the reader to be cognizant of this late complication. Published by Elsevier Inc.
C1 [Tran, Daniel D.] Tripler Army Med Ctr, US Army, Dept Otolaryngol, Honolulu, HI USA.
[Littlefield, Philip D.] Tripler Army Med Ctr, US Army, Honolulu, HI USA.
RP Tran, DD (reprint author), Tripler Army Med Ctr, 1 Jarrett White Rd, Honolulu, HI 96859 USA.
EM daniel.d.tran.mil@mail.mil
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PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0196-0709
EI 1532-818X
J9 AM J OTOLARYNG
JI Am. J. Otolaryngol.
PD MAR-APR
PY 2015
VL 36
IS 2
BP 299
EP 302
DI 10.1016/j.amjoto.2014.10.034
PG 4
WC Otorhinolaryngology
SC Otorhinolaryngology
GA CB9FJ
UT WOS:000349937100037
PM 25480365
ER
PT J
AU Tati, S
Ko, BJ
Cao, G
Swami, A
La Porta, TF
AF Tati, Srikar
Ko, Bong Jun
Cao, Guohong
Swami, Ananthram
La Porta, Thomas F.
TI Adaptive Algorithms for Diagnosing Large-Scale Failures in Computer
Networks
SO IEEE TRANSACTIONS ON PARALLEL AND DISTRIBUTED SYSTEMS
LA English
DT Article
DE Fault diagnosis; large-scale failures; incomplete information; clustered
failures
ID LOCALIZATION
AB We propose a greedy algorithm, Cluster-MAX-COVERAGE (CMC), to efficiently diagnose large-scale clustered failures. We primarily address the challenge of determining faults with incomplete symptoms. CMC makes novel use of both positive and negative symptoms to output a hypothesis list with a low number of false negatives and false positives quickly. CMC requires reports from about half as many nodes as other existing algorithms to determine failures with 100 percent accuracy. Moreover, CMC accomplishes this gain significantly faster (sometimes by two orders of magnitude) than an algorithm that matches its accuracy. When there are fewer positive and negative symptoms at a reporting node, CMC performs much better than existing algorithms. We also propose an adaptive algorithm called Adaptive-MAX-COVERAGE (AMC) that performs efficiently during both independent and clustered failures. During a series of failures that include both independent and clustered, AMC results in a reduced number of false negatives and false positives.
C1 [Tati, Srikar; Cao, Guohong; La Porta, Thomas F.] Penn State Univ, Inst Networking & Secur Res, University Pk, PA 16802 USA.
[Ko, Bong Jun] IBM Corp, TJ Watson Res Ctr, Hawthorne, NY 10532 USA.
[Swami, Ananthram] Army Res Lab, Adelphi, MD USA.
RP Tati, S (reprint author), Penn State Univ, Inst Networking & Secur Res, University Pk, PA 16802 USA.
EM tati@cse.psu.edu; bongjun_ko@us.ibm.com; gcao@cse.psu.edu;
ananthram.swami.civ@mail.mil; tlp@cse.psu.edu
FU US Army Research Laboratory; United Kingdom Ministry of Defence; Defense
Threat Reduction Agency [HDTRA1-10-1-0085]; [W911NF-06-3-0001]
FX The authors acknowledge the inputs of Daniel Kifer. This research was
sponsored by the US Army Research Laboratory and the United Kingdom
Ministry of Defence, and was accomplished under Agreement Number
W911NF-06-3-0001. The views and conclusions contained in this document
are those of the author(s) and should not be interpreted as representing
the official policies, either expressed or implied, of the US Army
Research Laboratory, the US Government, the United Kingdom Ministry of
Defence or the United Kingdom Government. The US and the United Kingdom
Governments are authorized to reproduce and distribute reprints for
Government purposes notwithstanding any copyright notation hereon. This
work was supported in part by the Defense Threat Reduction Agency under
Grant HDTRA1-10-1-0085.
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PU IEEE COMPUTER SOC
PI LOS ALAMITOS
PA 10662 LOS VAQUEROS CIRCLE, PO BOX 3014, LOS ALAMITOS, CA 90720-1314 USA
SN 1045-9219
EI 1558-2183
J9 IEEE T PARALL DISTR
JI IEEE Trans. Parallel Distrib. Syst.
PD MAR
PY 2015
VL 26
IS 3
BP 646
EP 656
DI 10.1109/TPDS.2014.2311814
PG 11
WC Computer Science, Theory & Methods; Engineering, Electrical & Electronic
SC Computer Science; Engineering
GA CB6XG
UT WOS:000349769500003
ER
PT J
AU Chow, YL
Pavone, M
Sadler, BM
Carpin, S
AF Chow, Yin-Lam
Pavone, Marco
Sadler, Brian M.
Carpin, Stefano
TI Trading Safety Versus Performance: Rapid Deployment of Robotic Swarms
With Robust Performance Constraints
SO JOURNAL OF DYNAMIC SYSTEMS MEASUREMENT AND CONTROL-TRANSACTIONS OF THE
ASME
LA English
DT Article
ID COVERAGE
AB In this paper, we consider a stochastic deployment problem, where a robotic swarm is tasked with the objective of positioning at least one robot at each of a set of pre-assigned targets while meeting a temporal deadline. Travel times and failure rates are stochastic but related, inasmuch as failure rates increase with speed. To maximize chances of success while meeting the deadline, a control strategy has therefore to balance safety and performance. Our approach is to cast the problem within the theory of constrained Markov decision processes (CMDPs), whereby we seek to compute policies that maximize the probability of successful deployment while ensuring that the expected duration of the task is bounded by a given deadline. To account for uncertainties in the problem parameters, we consider a robust formulation and we propose efficient solution algorithms, which are of independent interest. Numerical experiments confirming our theoretical results are presented and discussed.
C1 [Chow, Yin-Lam] Stanford Univ, Inst Computat & Math Engn, Stanford, CA 94305 USA.
[Pavone, Marco] Stanford Univ, Dept Aeronaut & Astronaut, Stanford, CA 94305 USA.
[Sadler, Brian M.] Army Res Lab, Adelphi, MD 20783 USA.
[Carpin, Stefano] Univ Calif, Sch Engn, Merced, CA 95343 USA.
RP Chow, YL (reprint author), Stanford Univ, Inst Computat & Math Engn, Stanford, CA 94305 USA.
EM ychow@stanford.edu; pavone@stanford.edu; brian.m.sadler6.civ@mail.mil;
scarpin@ucmerced.edu
FU ARL [MAST-SUPP-13-6-CNC]
FX Stefano Carpin is partially supported by ARL under Contract
MAST-SUPP-13-6-CNC. Any opinions, findings, and conclusions or
recommendations expressed in these materials are those of the authors
and should not be interpreted as representing the official policies,
either expressly or implied, of the funding agencies of the U.S.
Government.
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PU ASME
PI NEW YORK
PA TWO PARK AVE, NEW YORK, NY 10016-5990 USA
SN 0022-0434
EI 1528-9028
J9 J DYN SYST-T ASME
JI J. Dyn. Syst. Meas. Control-Trans. ASME
PD MAR
PY 2015
VL 137
IS 3
SI SI
AR 031005
DI 10.1115/1.4028117
PG 11
WC Automation & Control Systems; Instruments & Instrumentation
SC Automation & Control Systems; Instruments & Instrumentation
GA CB6RO
UT WOS:000349754500007
ER
PT J
AU Kaldy, JE
Shafer, DJ
Magoun, AD
AF Kaldy, James E.
Shafer, Deborah J.
Magoun, A. Dale
TI Duration of temperature exposure controls growth of Zostera japonica:
Implications for zonation and colonization
SO JOURNAL OF EXPERIMENTAL MARINE BIOLOGY AND ECOLOGY
LA English
DT Article
DE Introduced seagrass; Pulsed temperature; Zonation control; Zostera
japonica
ID MARINA L.; VERTICAL-DISTRIBUTION; HALODULE-WRIGHTII; TEMPORAL PATTERNS;
PACIFIC-NORTHWEST; SEAGRASS; BAY; WASHINGTON; SEEDLINGS; DYNAMICS
AB At least two seagrass congeners in the genus Zostera are found along the Pacific Coast of North America: native Zostera marina L and the non-native Zostera japonica Aschers. & Graebn. Efforts to understand the drivers behind the expanding colonization of Z. japonica have led to interest in the biology and ecology of this species. In most locations where they co-occur, these species exhibit a disjunct vertical zonation. We experimentally consider the influence of pulsed temperature effects on Z. japonica growth as a driver of vertical zonation. In mesocosm tanks seagrass planting units were cycled from ambient to treatment temperatures (8, 20, 32 degrees C) of variable duration (2, 6, 12, 24 h) each day for 10 d and then growth was assessed. Leaf elongation and growth rates exhibited strong, statistically significant relationships with increasing duration of exposure to 20 degrees C. Plants exposed to continuous 20 degrees C temperatures grew 2.5 times faster than plants exposed to 20 degrees C for 2 h. Likewise, plants exposed to continuous 8 degrees C temperatures grew 2.5 times slower than plants at 8 degrees C for 2 h. Plants exposed to 32 degrees C maintained fairly constant growth and elongation rates regardless of the duration of exposure. Field data indicate that Z. japonica and Z. marina experience different thermal regimes in the same estuary. We suggest that intertidal zonation patterns of Z. japonica in North America are predominantly driven by seagrass temperature responses; increased duration of exposure to cold water temperatures appears to limit expansion of the Z. japonica bed lower boundary to the mid-intertidal. Additionally, we recognize characteristics that may be useful to identifying systems susceptible to colonization. Published by Elsevier B.V.
C1 [Kaldy, James E.] US EPA, Western Ecol Div, Newport, OR 97365 USA.
[Shafer, Deborah J.] US Army Corps Engn, Engn Res & Dev Ctr, Vicksburg, MS 39180 USA.
[Magoun, A. Dale] Appl Res & Anal Inc, Tallulah, LA 71284 USA.
RP Kaldy, JE (reprint author), US EPA, Western Ecol Div, 2111 SE Marine Sci Dr, Newport, OR 97365 USA.
EM kaldy.jim@epa.gov
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PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0022-0981
EI 1879-1697
J9 J EXP MAR BIOL ECOL
JI J. Exp. Mar. Biol. Ecol.
PD MAR
PY 2015
VL 464
BP 68
EP 74
PG 7
WC Ecology; Marine & Freshwater Biology
SC Environmental Sciences & Ecology; Marine & Freshwater Biology
GA CB6IK
UT WOS:000349730500009
ER
PT J
AU Videen, G
Sun, WB
Kocifaj, M
Kai, KJ
Kawamoto, K
Horvath, H
Mishchenko, M
AF Videen, Gorden
Sun, Wenbo
Kocifaj, Miroslav
Kai, Kenji
Kawamoto, Kazuaki
Horvath, Helmuth
Mishchenko, Michael
TI Topical issue on optical particle characterization and remote sensing of
the atmosphere: Part II
SO JOURNAL OF QUANTITATIVE SPECTROSCOPY & RADIATIVE TRANSFER
LA English
DT Editorial Material
ID 3-DIMENSIONAL DATA ASSIMILATION; SURFACE PRESSURE MEASUREMENTS;
ABSORPTION RADAR SYSTEM; LIGHT-SCATTERING; VALIDATION; MORPHOLOGY;
AEROSOLS; IMPACT; LIDAR; DUST
C1 [Videen, Gorden] INTA, Madrid 28850, Spain.
[Videen, Gorden] Univ Cantabria, Fac Ciencias, Dept Fis Aplicada, Grp Opt, E-39005 Santander, Spain.
[Videen, Gorden] US Army Res Lab, Adelphi, MD 20783 USA.
[Videen, Gorden] Space Sci Inst, Boulder, CO 80301 USA.
[Sun, Wenbo] Sci Syst & Applicat Inc, Hampton, VA 23666 USA.
[Kocifaj, Miroslav] Slovak Acad Sci, Bratislava 84503, Slovakia.
[Kai, Kenji] Nagoya Univ, Chikusa Ku, Nagoya, Aichi 4648601, Japan.
[Kawamoto, Kazuaki] Nagasaki Univ, Fac Environm Studies, Nagasaki 852, Japan.
[Horvath, Helmuth] Univ Vienna, Dept Phys, A-1090 Vienna, Austria.
[Mishchenko, Michael] NASA, Goddard Inst Space Studies, New York, NY 10025 USA.
RP Videen, G (reprint author), INTA, Ctra Ajalvir Km 4, Madrid 28850, Spain.
EM gorden.w.videen.civ@mail.mil
RI Mishchenko, Michael/D-4426-2012
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PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0022-4073
EI 1879-1352
J9 J QUANT SPECTROSC RA
JI J. Quant. Spectrosc. Radiat. Transf.
PD MAR
PY 2015
VL 153
SI SI
BP 1
EP 3
DI 10.1016/j.jqsrt.2015.01.005
PG 3
WC Optics; Spectroscopy
SC Optics; Spectroscopy
GA CB8MH
UT WOS:000349883200001
ER
PT J
AU Wang, CJ
Pan, YL
Hill, SC
Redding, B
AF Wang, Chuji
Pan, Yong-Le
Hill, Steven C.
Redding, Brandon
TI Photophoretic trapping-Raman spectroscopy for single pollens and fungal
spores trapped in air
SO JOURNAL OF QUANTITATIVE SPECTROSCOPY & RADIATIVE TRANSFER
LA English
DT Article
DE Optical trapping; Raman spectroscopy; Bioaerosols; Pollen; Fungal
spores; Single particle trapped in air
ID FLUORESCENCE-SPECTRUM ANALYZER; AIRBORNE BIOLOGICAL PARTICLES; RELEVANT
MICROORGANISMS; ATMOSPHERIC BIOAEROSOLS; ABSORBING PARTICLES; RADIATION
PRESSURE; AEROSOL-PARTICLES; AQUEOUS-SOLUTION; BACTERIAL-CELLS;
IDENTIFICATION
AB Photophoretic trapping-Raman spectroscopy (PTRS) is a new technique for measuring Raman spectra of particles that are held in air using photophoretic forces. It was initially demonstrated with Raman spectra of strongly-absorbing carbon nanoparticles (Pan et al. [44] (Opt Express 2012)). In the present paper we report the first demonstration of the use of PTRS to measure Raman spectra of absorbing and weakly-absorbing bioaerosol particles (pollens and spores). Raman spectra of three pollens and one smut spore in a size range of 6.2-41.8 mu m illuminated at 488 nm are shown. Quality spectra were obtained in the Raman shift range of 1600-3400 cm(-1) in this exploratory study. Distinguishable Raman scattering signals with one or a few clear Raman peaks for all four aerosol particles were observed within the wavenumber region 2940-3030 cm(-1). Peaks in this region are consistent with previous reports of Raman peaks in the 1600-3400 cm(-1) range for pollens and spores excited at 514 nm measured by a conventional Raman spectrometer. Noise in the spectra, the fluorescence background, and the weak Raman signals in most of the 1600-3400 cm(-1) region make some of the spectral features barely discernable or not discernable for these bioaerosols except the strong signal within 2940-3030 cm(-1). Up to five bands are identified in the three pollens and only two bands appear in the fungal spore, but this may be because the fungal spore is so much smaller than any of the pollens. The fungal spore signal relative to the air-nitrogen Raman band is approximately 10 times smaller than that ratio for the pollens. The five bands are tentatively assigned to the CH2 symmetric stretch at 2948 cm(-1), CH2 Fermi resonance stretch at 2970 cm(-1), CH3 symmetric stretch at 2990 cm(-1), CH3 out-of-plane end asymmetric stretch at 3010 cm(-1), and unsaturated = CH stretch at 3028 cm(-1). The two dominant bands of the up-to-five Raman bands in the 2940-3030 cm(-1) region have a consistent band spacing of 25 cm(-1) in all four aerosols. Finally we discuss improvements to the PTRS that should provide a system which can trap a higher fraction of particle types and obtain Raman spectra over a larger range (e.g., 200-3600 cm(-1)) than those achieved here. Published by Elsevier Ltd.
C1 [Wang, Chuji; Pan, Yong-Le; Hill, Steven C.; Redding, Brandon] US Army Res Lab, Adelphi, MD 20783 USA.
[Wang, Chuji] Mississippi State Univ, Starkville, MS 39759 USA.
RP Pan, YL (reprint author), US Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA.
EM yongle.pan.civ@mail.mil
FU Defense Threat Reduction Agency (DTRA) [HDTRA136477, HDTRA1310184]; US
Army Research Laboratory mission funds; US Army Research Office
[W911NF-13-1-0429, W911NF-13-1-0297]
FX This research was supported by the Defense Threat Reduction Agency
(DTRA) under Contract number HDTRA136477 and HDTRA1310184, US Army
Research Laboratory mission funds, and US Army Research Office Grants
W911NF-13-1-0429 and W911NF-13-1-0297.
NR 63
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U1 2
U2 31
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0022-4073
EI 1879-1352
J9 J QUANT SPECTROSC RA
JI J. Quant. Spectrosc. Radiat. Transf.
PD MAR
PY 2015
VL 153
SI SI
BP 4
EP 12
DI 10.1016/j.jqsrt.2014.11.004
PG 9
WC Optics; Spectroscopy
SC Optics; Spectroscopy
GA CB8MH
UT WOS:000349883200002
ER
PT J
AU Ratnesar-Shumate, S
Pan, YL
Hill, SC
Kinahan, S
Corson, E
Eshbaugh, J
Santarpia, JL
AF Ratnesar-Shumate, Shanna
Pan, Yong-Le
Hill, Steven C.
Kinahan, Sean
Corson, Elizabeth
Eshbaugh, Jonathan
Santarpia, Joshua L.
TI Fluorescence spectra and biological activity of aerosolized bacillus
spores and MS2 bacteriophage exposed to ozone at different relative
humidities in a rotating drum
SO JOURNAL OF QUANTITATIVE SPECTROSCOPY & RADIATIVE TRANSFER
LA English
DT Article
DE Bioaerosols; Spectroscopy; Bacillus; Bacteriophage; Ozone; Relative
humidity
ID REAL-TIME MEASUREMENT; OPEN-AIR; BIOAEROSOLS; EXCITATION; WAVELENGTH;
PARTICLES; PROTEINS; MODEL; DNA
AB Biological aerosols (bioaerosols) released into the environment may undergo physical and chemical transformations when exposed to atmospheric constituents such as solar irradiation, reactive oxygenated species, ozone, free radicals, water vapor and pollutants. Aging experiments were performed in a rotating drum chamber subjecting bioaerosols, Bacillus thuringiensis Al Hakam (BtAH) spores and MS2 bacteriophages to ozone at 0 and 150 ppb, and relative humidities (RH) at 10%, 50%, and 80+%. Fluorescence spectra and intensities of the aerosols as a function of time in the reaction chamber were measured with a single particle fluorescence spectrometer (SPFS) and an Ultra-Violet Aerodynamic Particle Sizer (R) Spectrometer (UV-APS). Losses in biological activity were measured by culture and quantitative polymerase chain reaction (q-PCR) assay. For both types of aerosols the largest change in fluorescence emission was between 280 and 400 nm when excited at 263 nm followed by fluorescence emission between 380 and 700 nm when excited at 351 nm. The fluorescence for both BtAH and MS2 were observed to decrease significantly at high ozone concentration and high RH when excited at 263 nm excitation. The decreases in 263 nm excited fluorescence are indicative of hydrolysis and oxidation of tryptophan in the aerosols. Fluorescence measured with the UV-APS (355-nm excitation) increased with time for both BtAH and MS2 aerosols. A two log loss of MS2 bacteriophage infectivity was observed in the presence of ozone at similar to 50% and 80% RH when measured by culture and normalized for physical losses by q-PCR. Viability of BtAH spores after exposure could not be measured due to the loss of genomic material during experiments, suggesting degradation of extracelluar DNA attributable to oxidation. The results of these studies indicate that the physical and biological properties of bioaerosols change significantly after exposure to ozone and water vapor. (c) 2014 The Authors. Published by Elsevier Ltd.
C1 [Ratnesar-Shumate, Shanna; Kinahan, Sean; Corson, Elizabeth; Eshbaugh, Jonathan] Johns Hopkins Univ, Appl Phys Lab, Laurel, MD USA.
[Ratnesar-Shumate, Shanna; Santarpia, Joshua L.] Univ Maryland Baltimore Cty, Baltimore, MD 21250 USA.
[Pan, Yong-Le; Hill, Steven C.] US Army Res Lab, Adelphi, MD 20783 USA.
[Santarpia, Joshua L.] Sandia Natl Labs, Albuquerque, NM 87123 USA.
RP Santarpia, JL (reprint author), Sandia Natl Labs, 1515 Eubank SE, Albuquerque, NM 87123 USA.
EM jsantar@sandia.gov
FU Defense Threat Reduction Agency
FX The authors would like to thank Dr. Sari Paikoff at the Defense Threat
Reduction Agency for providing the funding for this research.
NR 32
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U1 4
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PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0022-4073
EI 1879-1352
J9 J QUANT SPECTROSC RA
JI J. Quant. Spectrosc. Radiat. Transf.
PD MAR
PY 2015
VL 153
SI SI
BP 13
EP 28
DI 10.1016/j.jqsrt.2014.10.003
PG 16
WC Optics; Spectroscopy
SC Optics; Spectroscopy
GA CB8MH
UT WOS:000349883200003
ER
PT J
AU Bianchini, A
Gonzalez, CR
AF Bianchini, Alessandra
Gonzalez, Carlos R.
TI Reformulation of the Design Procedure for Aggregate-Surfaced Airfield
Pavements
SO JOURNAL OF TRANSPORTATION ENGINEERING
LA English
DT Article
DE Unsurfaced pavement; Design procedure; Airfield pavement; Frohlich
stress distribution
AB During military contingency operations, aircraft are required to land, taxi, and takeoff on unpaved surfaces. In some cases, operational time limitations do not allow for the construction of paved surfaces to establish airfield operations. The original flexible pavement design procedure for paved surfaces, which is based on the California Bearing Ratio (CBR) and the -factor (Alpha-factor), was extended and applied to the design and evaluation of aggregate-surfaced pavements. With the reformulation of the CBR-Alpha for the design of flexible pavements, efforts were also directed at defining a new equation for the design of aggregate-surfaced airfields. This paper focuses on the development of a new CBR-Beta procedure for the design and evaluation of aggregate-surfaced airfields. Data from previous studies conducted on aggregate-surfaced full-scale test sections were used for this purpose. The new performance curve proposed in this paper for aggregate-surfaced airfields has the same format as the equation that was proposed and accepted for flexible pavements.
C1 [Bianchini, Alessandra] Air Force Civil Engn Ctr AFCEC CXAE, Tyndall AFB, FL 32403 USA.
[Bianchini, Alessandra; Gonzalez, Carlos R.] US Army, Engn Res & Dev Ctr, Vicksburg, MS 39180 USA.
RP Bianchini, A (reprint author), Air Force Civil Engn Ctr AFCEC CXAE, 139 Barnes Dr,Suite 2, Tyndall AFB, FL 32403 USA.
EM Alessandra.Bianchini@us.af.mil; carlos.r.gonzalez@usace.army.mil
NR 15
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Z9 0
U1 2
U2 9
PU ASCE-AMER SOC CIVIL ENGINEERS
PI RESTON
PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA
SN 0733-947X
EI 1943-5436
J9 J TRANSP ENG
JI J. Transp. Eng.
PD MAR
PY 2015
VL 141
IS 3
AR 04014086
DI 10.1061/(ASCE)TE.1943-5436.0000752
PG 12
WC Engineering, Civil; Transportation Science & Technology
SC Engineering; Transportation
GA CB7YT
UT WOS:000349845500005
ER
PT J
AU Williams, SG
Collen, J
Orr, N
Holley, AB
Lettieri, CJ
AF Williams, Scott G.
Collen, Jacob
Orr, Nicholas
Holley, Aaron B.
Lettieri, Christopher J.
TI Sleep disorders in combat-related PTSD
SO SLEEP AND BREATHING
LA English
DT Article
DE Combat related sleep disorder; Insomnia; Obstructive sleep apnea;
Sleep-disordered breathing; Post-traumatic stress disorder
ID POSTTRAUMATIC-STRESS-DISORDER; SEXUAL-ASSAULT SURVIVORS; MILITARY
PERSONNEL; CRIME VICTIMS; FIRE EVACUEES; SYMPTOMS; APNEA; VETERANS;
INSOMNIA; DISTURBANCE
AB We sought to assess the rate of sleep complaints and sleep disorders among active duty soldiers with deployment-related PTSD and to determine whether any clinical features differentiated those with sleep disorders.
Retrospective review of consecutive soldiers diagnosed with PTSD. We recorded subjective measures of sleep and polysomnographic data. We compared clinical and demographic variables including psychoactive medication use, psychiatric comorbidity, and combat-related traumatic injury with the presence of sleep disorders.
One hundred thirty patients were included (91.5 % male, mean age of 35.1 +/- 10.6 years, mean body mass index (BMI) 28.9 +/- 4.4 Kg/m(2)). About 88.5 % had comorbid depression, with the majority (96.2 %) taking psychoactive medications (mean 3.4 +/- 1.6 medications per patient). Over half of the cohort suffered combat-related traumatic physical injuries (54.6 %). The obstructive sleep apnea syndrome (OSAS) was diagnosed in 67.3 % (80 % of the cohort underwent polysomnography), with a mean apnea hypopnea index of 24.1 +/- 22.8 events/hour and a mean oxygen saturation nadir of 84.2 +/- 5.7 %. OSAS was significantly more common in the non-injured soldiers (72.9 vs. 38.0 %, p < 0.001). In multivariate analysis, absence of physical injury showed a trend towards predicting OSAS.
Sleep complaints are common among soldiers with PTSD. We observed significantly higher rates of OSAS among those without physical injuries, raising the possibility that underlying sleep-disordered breathing is a risk factor for the development of PTSD. This potential association requires further validation.
C1 [Williams, Scott G.] Womack Army Med Ctr, Ft Bragg, NC USA.
[Collen, Jacob] San Antonio Mil Med Ctr, Pulm Dis Serv, Houston, TX 78234 USA.
[Orr, Nicholas] Walter Reed Natl Mil Med Ctr, Dept Cardiol, Bethesda, MD USA.
[Holley, Aaron B.; Lettieri, Christopher J.] Walter Reed Natl Mil Med Ctr, Bethesda, MD USA.
[Williams, Scott G.; Holley, Aaron B.; Lettieri, Christopher J.] Uniformed Serv Univ Hlth Sci, Dept Med, Bethesda, MD 20814 USA.
RP Collen, J (reprint author), San Antonio Mil Med Ctr, Pulm Dis Serv, 3551 Roger Brooke Dr, Houston, TX 78234 USA.
EM jacob.f.collen.mil@mail.mil
NR 59
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Z9 7
U1 3
U2 11
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1520-9512
EI 1522-1709
J9 SLEEP BREATH
JI Sleep Breath.
PD MAR
PY 2015
VL 19
IS 1
BP 175
EP 182
DI 10.1007/s11325-014-0984-y
PG 8
WC Clinical Neurology; Respiratory System
SC Neurosciences & Neurology; Respiratory System
GA CB9WG
UT WOS:000349983900033
PM 24752303
ER
PT J
AU Witkowski, S
Trujillo, LT
Sherman, SM
Carter, P
Matthews, MD
Schnyer, DM
AF Witkowski, Sarah
Trujillo, Logan T.
Sherman, Stephanie M.
Carter, Patricia
Matthews, Michael D.
Schnyer, David M.
TI An examination of the association between chronic sleep restriction and
electrocortical arousal in college students
SO CLINICAL NEUROPHYSIOLOGY
LA English
DT Article
DE Chronic sleep restriction; PVT; ERP; EEG; Actigraphy; Circadian rhythms
ID MILD COGNITIVE IMPAIRMENT; CIRCADIAN-RHYTHMS; SUSTAINED ATTENTION;
PERFORMANCE DECREMENTS; ALZHEIMERS-DISEASE; DEPRIVATION; VIGILANCE;
ACTIGRAPHY; POTENTIALS; EEG
AB Objective: The deleterious neurocognitive effects of laboratory-controlled short-term sleep deprivation are well-known. The present study investigated neurocognitive changes arising from chronic sleep restriction outside the laboratory.
Methods: Sleep patterns of 24 undergraduates were tracked via actigraphy across a 15-week semester. At the semester beginning, at a midpoint, and a week before finals, students performed the Psychomotor Vigilance Test (PVT) and cortical arousal was measured via event-related potentials (ERP) and resting state electroencephalography (EEG).
Results: Average daily sleep decreased between Session 1 and Sessions 2 and 3. Calculated circadian rhythm measures indicated nighttime movement increased and sleep quality decreased from Sessions 1 and 2 to Session 3. Parallel to the sleep/activity measures, PVT reaction time increased between Session 1 and Sessions 2 and 3 and resting state alpha EEG reactivity magnitude and PVT-evoked P3 ERP amplitude decreased between Session 1 and Sessions 2 and 3. Cross-sectional regressions showed PVT reaction time was negatively associated with average daily sleep, alpha reactivity, and P3 changes; sleep/circadian measures were associated with alpha reactivity and/or P3 changes.
Conclusions: Small, but persistent sleep deficits reduced cortical arousal and impaired vigilant attention.
Significance: Chronic sleep restriction impacts neurocognition in a manner similar to laboratory controlled sleep deprivation. (C) 2014 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.
C1 [Witkowski, Sarah; Trujillo, Logan T.; Sherman, Stephanie M.; Schnyer, David M.] Univ Texas Austin, Dept Psychol, Austin, TX 78712 USA.
[Carter, Patricia] Univ Texas Austin, Sch Nursing, Austin, TX 78712 USA.
[Matthews, Michael D.] US Mil Acad, Dept Behav Sci & Leadership, West Point, NY USA.
RP Witkowski, S (reprint author), Univ Texas Austin, Dept Psychol, 108 E Dean Keaton,Stop A8000, Austin, TX 78712 USA.
EM Sadie.witkowski@utexas.edu
OI Witkowski, Sarah/0000-0002-9140-3088
FU Army Grant via The Center for Strategic and Innovative Technologies at
UT-Austin [W911NF-07-2-0023]; Chief of Staff of the Army
FX This research was funded by Army Grant W911NF-07-2-0023 via The Center
for Strategic and Innovative Technologies at UT-Austin and Chief of
Staff of the Army - Grant to West Point's Network Science Center.
NR 64
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U2 18
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
IRELAND
SN 1388-2457
EI 1872-8952
J9 CLIN NEUROPHYSIOL
JI Clin. Neurophysiol.
PD MAR
PY 2015
VL 126
IS 3
BP 549
EP 557
DI 10.1016/j.clinph.2014.06.026
PG 9
WC Clinical Neurology; Neurosciences
SC Neurosciences & Neurology
GA CB4RX
UT WOS:000349616700018
PM 25043966
ER
PT J
AU Pidcoke, HF
Cap, AP
AF Pidcoke, Heather F.
Cap, Andrew P.
TI Refrigerated Platelets for the Treatment of Acute Bleeding: A Review of
the Literature and Reexamination of Current Standards: Reply
SO SHOCK
LA English
DT Letter
C1 [Pidcoke, Heather F.; Cap, Andrew P.] US Army, Inst Surg Res, San Antonio, TX 78234 USA.
RP Pidcoke, HF (reprint author), US Army, Inst Surg Res, San Antonio, TX 78234 USA.
NR 3
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U1 0
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1073-2322
EI 1540-0514
J9 SHOCK
JI Shock
PD MAR
PY 2015
VL 43
IS 3
BP 298
EP +
DI 10.1097/SHK.0000000000000299
PG 3
WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease
SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System
& Cardiology
GA CB1UE
UT WOS:000349412700016
PM 26091026
ER
PT J
AU Beck, Z
Matyas, GR
Alving, CR
AF Beck, Zoltan
Matyas, Gary R.
Alving, Carl R.
TI Detection of liposomal cholesterol and monophosphoryl lipid A by QS-21
saponin and Limulus polyphemus amebocyte lysate
SO BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
LA English
DT Article
DE Liposomal model membranes; Lipid bilayer heterogeneity; Cholesterol;
QS-21 saponin; Monophosphotyl lipid A; Limulus amebocyte lysate
ID PHOSPHATIDYLCHOLINE-CHOLESTEROL; PHOSPHOLIPID-VESICLES;
BIOLOGICAL-MEMBRANES; UNILAMELLAR VESICLES; ADJUVANT SYSTEMS; MODEL
MEMBRANES; RICH DOMAINS; EXCHANGE; BILAYERS; VACCINE
AB Liposomes containing cholesterol (Chol) have long been used as an important membrane system for modeling the complex interactions of Chol with adjacent phospholipids or other lipids in a membrane environment. In this study we utilize a probe composed of QS-21, a saponin molecule that recognizes liposomal Chol and causes hemolysis of erythrocytes. The interaction of QS-21 with liposomal Chol results in a stable formulation which, after injection into the tissues of an animal, lacks toxic effects of QS-21 on neighboring cells that contain Chol, such as erythrocytes. Here we have used liposomes containing different saturated phospholipid fatty acyl groups and Chol, with or without monophosphoryl lipid A (MPLA), as model membranes. QS-21 is then employed as a probe to study the interactions of liposomal lipids on the visibility of membrane Chol. We demonstrate that changes either in the mole fraction of Chol in liposomes, or with different chain lengths of phospholipid fatty acyl groups, can have a substantial impact on the detection of Chol by the QS-21. We further show that liposomal MPLA can partially inhibit detection of the liposomal Chol by QS-21. The Limulus amebocyte lysate assay is used for binding to and detection of MPLA. Previous work has demonstrated that sequestration of MPLA into the liposomal lipid bilayer can block detection by the Limulus assay, but the binding site on the MPLA to which the Limulus protein binds is unknown. Changes in liposomal Chol concentration and phospholipid fatty acyl chain length influenced the detection of the liposome-embedded MPLA. Published by Elsevier B.V.
C1 [Beck, Zoltan] Henry M Jackson Fdn Adv Mil Med, US Mil HIV Res Program, Bethesda, MD 20817 USA.
[Beck, Zoltan; Matyas, Gary R.; Alving, Carl R.] Walter Reed Army Inst Res, US Mil HIV Res Program, Lab Adjuvant & Antigen Res, Silver Spring, MD 20910 USA.
RP Alving, CR (reprint author), Walter Reed Army Inst Res, US Mil HIV Res Program, Lab Adjuvant & Antigen Res, 503 Robert Grant Ave, Silver Spring, MD 20910 USA.
EM calving@hivresearch.org
OI Matyas, Gary/0000-0002-2074-2373
FU Henry M. Jackson Foundation [W81XWH-11-2-0174]; U.S. Army Medical
Research and Materiel Command (MRMC)
FX This work was supported through a Cooperative Agreement
(W81XWH-11-2-0174) between the Henry M. Jackson Foundation for the
Advancement of Military Medicine and the U.S. Army Medical Research and
Materiel Command (MRMC). The authors thank Mr. Christopher Spiridon for
technical assistance. The views expressed in this article are those of
the authors and do not necessarily reflect the official policy of the
Department of the Army, Department of Defense, or the U.S. Government
NR 59
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U1 2
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PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0005-2736
EI 0006-3002
J9 BBA-BIOMEMBRANES
JI Biochim. Biophys. Acta-Biomembr.
PD MAR
PY 2015
VL 1848
IS 3
BP 775
EP 780
DI 10.1016/j.bbamem.2014.12.005
PG 6
WC Biochemistry & Molecular Biology; Biophysics
SC Biochemistry & Molecular Biology; Biophysics
GA CB4FB
UT WOS:000349582500004
PM 25511587
ER
PT J
AU Chen, L
Chen, J
Lebensohn, RA
Ji, YZ
Heo, TW
Bhattacharyya, S
Chang, K
Mathaudhu, S
Liu, ZK
Chen, LQ
AF Chen, L.
Chen, J.
Lebensohn, R. A.
Ji, Y. Z.
Heo, T. W.
Bhattacharyya, S.
Chang, K.
Mathaudhu, S.
Liu, Z. K.
Chen, L. -Q.
TI An integrated fast Fourier transform-based phase-field and crystal
plasticity approach to model recrystallization of three dimensional
polycrystals
SO COMPUTER METHODS IN APPLIED MECHANICS AND ENGINEERING
LA English
DT Article
DE Phase-field method; Crystal plasticity; Grain growth; Recrystallization
ID STATIC RECRYSTALLIZATION; ELASTIC INHOMOGENEITY; NONLINEAR COMPOSITES;
CELLULAR-AUTOMATON; NUMERICAL-METHOD; SUBGRAIN GROWTH; SIMULATION;
EVOLUTION; MICROSTRUCTURE; KINETICS
AB A fast Fourier transform (FFT) based computational approach integrating phase-field method (PFM) and crystal plasticity (CP) is proposed to model recrystallization of plastically deformed polycrystals in three dimensions (3-D). CP at the grain level is employed as the constitutive description to predict the inhomogeneous distribution of strain and stress fields after plastic deformation of a polycrystalline aggregate while the kinetics of recrystallization is obtained employing a PFM in the plastically deformed grain structure. The elasto-viscoplastic equilibrium is guaranteed during each step of temporal phase-field evolution. Static recrystallization involving plasticity during grain growth is employed as an example to demonstrate the proposed computational framework. The simulated recrystallization kinetics is compared using the classical Johnson-Mehl-Avrami-Kolmogorov (JMAK) theory. This study also gives us a new computational pathway to explore the plasticity-driven evolution of 3D microstructures. Published by Elsevier B.V.
C1 [Chen, L.; Ji, Y. Z.; Heo, T. W.; Bhattacharyya, S.; Chang, K.; Liu, Z. K.; Chen, L. -Q.] Penn State Univ, Dept Mat Sci & Engn, University Pk, PA 16802 USA.
[Chen, J.] Penn State Univ, Altoona Coll, Dept Engn, Altoona, PA 16601 USA.
[Lebensohn, R. A.] Los Alamos Natl Lab, Mat Sci & Technol Div, Los Alamos, NM 87845 USA.
[Mathaudhu, S.] US Army Res Off, Div Mat Sci, Res Triangle Pk, NC 27709 USA.
RP Chen, L (reprint author), Penn State Univ, Dept Mat Sci & Engn, University Pk, PA 16802 USA.
EM luc28@psu.edu
RI Mathaudhu, Suveen/B-4192-2009; Lebensohn, Ricardo/A-2494-2008; Liu,
Zi-Kui/A-8196-2009;
OI Lebensohn, Ricardo/0000-0002-3152-9105; Liu, Zi-Kui/0000-0003-3346-3696;
Chen, Lei/0000-0002-3053-7373
FU Center for Computational Materials Design (CCMD); National Science
Foundation (NSF) Industry/University Cooperative Research Center at Penn
State [IIP-1034965]; Georgia Tech [IIP-1034968]
FX This work is funded by the Center for Computational Materials Design
(CCMD), a joint National Science Foundation (NSF) Industry/University
Cooperative Research Center at Penn State (IIP-1034965) and Georgia Tech
(IIP-1034968).
NR 49
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Z9 12
U1 10
U2 47
PU ELSEVIER SCIENCE SA
PI LAUSANNE
PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND
SN 0045-7825
EI 1879-2138
J9 COMPUT METHOD APPL M
JI Comput. Meth. Appl. Mech. Eng.
PD MAR 1
PY 2015
VL 285
BP 829
EP 848
DI 10.1016/j.cma.2014.12.007
PG 20
WC Engineering, Multidisciplinary; Mathematics, Interdisciplinary
Applications; Mechanics
SC Engineering; Mathematics; Mechanics
GA CB4ZR
UT WOS:000349637700036
ER
PT J
AU O'Bryan, TA
Rini, EA
Okulicz, JF
Messner, O
Ganesan, A
Lalani, T
Bavaro, MF
O'Connell, RJ
Agan, BK
Landrum, ML
AF O'Bryan, T. A.
Rini, E. A.
Okulicz, J. F.
Messner, O.
Ganesan, A.
Lalani, T.
Bavaro, M. F.
O'Connell, R. J.
Agan, B. K.
Landrum, M. L.
TI HIV viraemia during hepatitis B vaccination shortens the duration of
protective antibody levels
SO HIV MEDICINE
LA English
DT Article
DE antibody; hepatitis B; HIV; vaccine; viraemia
ID INFECTED ADULT PATIENTS; US MILITARY COHORT; IMMUNE MEMORY; T-CELL;
VIRUS; PERSISTENCE; INDIVIDUALS; RESPONSES; CHILDREN; RECOMMENDATIONS
AB ObjectivesIndividuals with HIV infection often have early waning of protective antibody following hepatitis B virus (HBV) vaccination. HIV viraemia at the time of vaccination may limit the durability of serum anti-HBV surface antibody (HBsAb) levels. We investigated the relationship of HIV plasma viral load (VL) and duration of HBsAb among vaccinees enrolled in the US Military HIV Natural History Study.
MethodsWe included in the study participants who had no history of prior HBV infection, who had received all HBV vaccine doses after HIV diagnosis, and who had demonstrated an initial vaccine response, defined as HBsAb 10IU/L. Responders were retrospectively followed with serial HBV serology from the time of the last vaccine dose until the development of waning (HBsAb <10IU/L) or the last HBsAb measurement. Time to and risk for waning were evaluated with Kaplan-Meier survival methods and Cox proportional hazards models, respectively.
ResultsA total of 186 initial vaccine responders were identified. During 570 person-years of observation, HBsAb waned in 52 of 186 participants (28%). The cumulative proportion maintaining HBsAb 10IU/L was 83% at 2 years and 56% at 5 years. Participants with an undetectable VL [hazard ratio (HR) 0.37; 95% confidence interval (CI) 0.18-0.76] or with detectable VL of 10000 copies/mL (HR 0.46; 95% CI 0.21-1.00) had reduced risk of waning. Other factors including age, number of vaccine doses, CD4 count, and receipt of highly active antiretroviral therapy (HAART) were not significantly associated with risk of waning HBsAb.
ConclusionsUndetectable or low HIV VL at the time of HBV vaccination is associated with greater durability of vaccine response in patients with HIV infection.
C1 [O'Bryan, T. A.; Messner, O.; Ganesan, A.; Lalani, T.; Agan, B. K.; Landrum, M. L.] Uniformed Serv Univ Hlth Sci, Infect Dis Clin Res Program, Bethesda, MD 20814 USA.
[O'Bryan, T. A.; Rini, E. A.; Okulicz, J. F.; Landrum, M. L.] San Antonio Mil Med Ctr, Ft Sam Houston, TX USA.
[Ganesan, A.] Walter Reed Natl Mil Med Ctr, Bethesda, MD USA.
[Lalani, T.] Naval Med Ctr, Portsmouth, VA USA.
[Bavaro, M. F.] Naval Med Ctr, San Diego, CA USA.
[O'Connell, R. J.] Walter Reed Army Inst Res, Silver Spring, MD USA.
RP O'Bryan, TA (reprint author), San Antonio Mil Med Ctr, Infect Dis Serv, 3551 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA.
EM thomas.a.obryan2.ctr@mail.mil
OI Agan, Brian/0000-0002-5114-1669
FU Infectious Disease Clinical Research Program (IDCRP), a Department of
Defense (DoD) programme through the Uniformed Services University of the
Health Sciences; National Institute of Allergy and Infectious Diseases,
National Institutes of Health (NIH) [Y1-AI-5072]
FX Support for this work was provided by the Infectious Disease Clinical
Research Program (IDCRP), a Department of Defense (DoD) programme
executed through the Uniformed Services University of the Health
Sciences. This project has been funded in whole, or in part, with
federal funds from the National Institute of Allergy and Infectious
Diseases, National Institutes of Health (NIH), under Inter-Agency
Agreement Y1-AI-5072. The content of this publication is the sole
responsibility of the authors and does not necessarily reflect the views
or policies of the NIH or the Department of Health and Human Services,
the DoD or the Departments of the Army, Navy or Air Force. Mention of
trade names, commercial products, or organizations does not imply
endorsement by the US Government.
NR 33
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U1 0
U2 3
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1464-2662
EI 1468-1293
J9 HIV MED
JI HIV Med.
PD MAR
PY 2015
VL 16
IS 3
BP 161
EP 167
DI 10.1111/hiv.12189
PG 7
WC Infectious Diseases
SC Infectious Diseases
GA CB2CR
UT WOS:000349434800003
PM 25586899
ER
PT J
AU Street, AE
Gilman, SE
Rosellini, AJ
Stein, MB
Bromet, EJ
Cox, KL
Colpe, LJ
Fullerton, CS
Gruber, MJ
Heeringa, SG
Lewandowski-Romps, L
Little, RJA
Naifeh, JA
Nock, MK
Sampson, NA
Schoenbaum, M
Ursano, RJ
Zaslavsky, AM
Kessler, RC
AF Street, A. E.
Gilman, S. E.
Rosellini, A. J.
Stein, M. B.
Bromet, E. J.
Cox, K. L.
Colpe, L. J.
Fullerton, C. S.
Gruber, M. J.
Heeringa, S. G.
Lewandowski-Romps, L.
Little, R. J. A.
Naifeh, J. A.
Nock, M. K.
Sampson, N. A.
Schoenbaum, M.
Ursano, R. J.
Zaslavsky, A. M.
Kessler, R. C.
CA Army STARRS Collaborators
TI Understanding the elevated suicide risk of female soldiers during
deployments
SO PSYCHOLOGICAL MEDICINE
LA English
DT Article
DE Army; Army STARRS; epidemiology; gender; military; risk factors; suicide
ID SERVICEMEMBERS ARMY STARRS; MENTAL-HEALTH; GENDER-DIFFERENCES; OEF/OIF
VETERANS; UNITED-STATES; US ARMY; MILITARY PERSONNEL; COMBAT DEPLOYMENT;
SEXUAL-HARASSMENT; RESILIENCE
AB Background. The Army Study to Assess Risk and Resilience in Servicemembers (Army STARRS) has found that the proportional elevation in the US Army enlisted soldier suicide rate during deployment (compared with the never-deployed or previously deployed) is significantly higher among women than men, raising the possibility of gender differences in the adverse psychological effects of deployment.
Method. Person-month survival models based on a consolidated administrative database for active duty enlisted Regular Army soldiers in 2004-2009 (n = 975 057) were used to characterize the gender x deployment interaction predicting suicide. Four explanatory hypotheses were explored involving the proportion of females in each soldier's occupation, the proportion of same-gender soldiers in each soldier's unit, whether the soldier reported sexual assault victimization in the previous 12 months, and the soldier's pre-deployment history of treated mental/behavioral disorders.
Results. The suicide rate of currently deployed women (14.0/100 000 person-years) was 3.1-3.5 times the rates of other (i.e. never-deployed/previously deployed) women. The suicide rate of currently deployed men (22.6/100 000 personyears) was 0.9-1.2 times the rates of other men. The adjusted (for time trends, sociodemographics, and Army career variables) female: male odds ratio comparing the suicide rates of currently deployed v. other women v. men was 2.8 (95% confidence interval 1.1-6.8), became 2.4 after excluding soldiers with Direct Combat Arms occupations, and remained elevated (in the range 1.9-2.8) after adjusting for the hypothesized explanatory variables.
Conclusions. These results are valuable in excluding otherwise plausible hypotheses for the elevated suicide rate of deployed women and point to the importance of expanding future research on the psychological challenges of deployment for women.
C1 [Street, A. E.] VA Boston Healthcare Syst, Natl Ctr PTSD, Boston, MA USA.
[Street, A. E.] Boston Univ, Sch Med, Dept Psychiat, Boston, MA 02118 USA.
[Gilman, S. E.] Harvard Univ, Sch Publ Hlth, Dept Social & Behav Sci, Boston, MA 02115 USA.
[Gilman, S. E.] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA.
[Rosellini, A. J.; Gruber, M. J.; Sampson, N. A.; Zaslavsky, A. M.; Kessler, R. C.] Harvard Univ, Sch Med, Dept Hlth Care Policy, Boston, MA 02115 USA.
[Stein, M. B.] Univ Calif San Diego, Dept Psychiat, La Jolla, CA 92093 USA.
[Stein, M. B.] Univ Calif San Diego, Dept Family & Prevent Med, La Jolla, CA 92093 USA.
[Stein, M. B.] VA San Diego Healthcare Syst, San Diego, CA USA.
[Bromet, E. J.] SUNY Stony Brook, Sch Med, Dept Psychiat, Stony Brook, NY 11794 USA.
[Cox, K. L.] US Army Publ Hlth Command, Aberdeen Proving Ground, MD USA.
[Colpe, L. J.] NIMH, Div Serv & Intervent Res, Bethesda, MD 20892 USA.
[Fullerton, C. S.; Naifeh, J. A.; Ursano, R. J.] Uniformed Serv Univ Hlth Sci, Dept Psychiat, Sch Med, Ctr Study Traumat Stress, Bethesda, MD 20814 USA.
[Heeringa, S. G.; Lewandowski-Romps, L.] Univ Michigan, Inst Social Res, Ann Arbor, MI USA.
[Little, R. J. A.] Univ Michigan, Dept Biostat, Ann Arbor, MI 48109 USA.
[Nock, M. K.] Harvard Univ, Dept Psychol, Cambridge, MA 02138 USA.
[Schoenbaum, M.] NIMH, Off Sci Policy Planning & Commun, Bethesda, MD 20892 USA.
RP Kessler, RC (reprint author), Harvard Univ, Sch Med, Dept Hlth Care Policy, 180 Longwood Ave, Boston, MA 02115 USA.
EM kessler@hcp.med.harvard.edu
RI Gilman, Stephen/E-7632-2010
OI Gilman, Stephen/0000-0002-8331-6419
FU Department of the Army; US Department of Health and Human Services,
National Institutes of Health, National Institute of Mental Health
(NIH/NIMH) [U01MH087981]
FX Army STARRS was sponsored by the Department of the Army and funded under
cooperative agreement number U01MH087981 with the US Department of
Health and Human Services, National Institutes of Health, National
Institute of Mental Health (NIH/NIMH). The contents are solely the
responsibility of the authors and do not necessarily represent the views
of the Department of Health and Human Services, NIMH, the Department of
the Army, or the DoD. Co-principal investigators are: Robert J. Ursano,
MD (Uniformed Services University of the Health Sciences) and Murray B.
Stein, MD, MPH (University of California San Diego and VA San Diego
Healthcare System). Site principal investigators are: Steven Heeringa,
PhD (University of Michigan) and Ronald C. Kessler, PhD (Harvard Medical
School). NIMH collaborating scientists are: Lisa J. Colpe, PhD, MPH and
Michael Schoenbaum, PhD. Army liaisons/consultants are: Col. Steven
Cersovsky, MD, MPH (US Army Public Health Command; USAPHC); Kenneth Cox,
MD, MPH (USAPHC). Other team members: Pablo A. Aliaga, MA (Uniformed
Services University of the Health Sciences); Col. David M. Benedek, MD
(Uniformed Services University of the Health Sciences); Susan Borja, PhD
(NIMH); Gregory G. Brown, PhD (University of California San Diego);
Laura Campbell-Sills, PhD (University of California San Diego);
Catherine L. Dempsey, PhD, MPH (Uniformed Services University of the
Health Sciences); Richard Frank, PhD (Harvard Medical School); Carol S.
Fullerton, PhD (Uniformed Services University of the Health Sciences);
Nancy Gebler, MA (University of Michigan); Robert K. Gifford, PhD
(Uniformed Services University of the Health Sciences); Stephen E.
Gilman, ScD (Harvard School of Public Health); Marjan G. Holloway, PhD
(Uniformed Services University of the Health Sciences); Paul E. Hurwitz,
MPH (Uniformed Services University of the Health Sciences); Sonia Jain,
PhD (University of California San Diego); Tzu-Cheg Kao, PhD (Uniformed
Services University of the Health Sciences); Karestan C. Koenen, PhD
(Columbia University); Lisa Lewandowski-Romps, PhD (University of
Michigan); Holly Herberman Mash, PhD (Uniformed Services University of
the Health Sciences); James E. McCarroll, PhD, MPH (Uniformed Services
University of the Health Sciences); Katie A. McLaughlin, PhD (Harvard
Medical School); James A. Naifeh, PhD (Uniformed Services University of
the Health Sciences); Matthew K. Nock, PhD (Harvard University); Rema
Raman, PhD (University of California San Diego); Sherri Rose, PhD
(Harvard Medical School); Anthony Joseph Rosellini, PhD (Harvard Medical
School); Nancy A. Sampson, BA (Harvard Medical School); LCDR Patcho
Santiago, MD, MPH (Uniformed Services University of the Health
Sciences); Michaelle Scanlon, MBA (NIMH); Jordan Smoller, MD, ScD
(Harvard Medical School); Michael L. Thomas, PhD (University of
California San Diego); Patti L. Vegella, MS, MA (Uniformed Services
University of the Health Sciences); Christina Wassel, PhD (University of
Pittsburgh); and Alan M. Zaslavsky, PhD (Harvard Medical School). A
complete list of Army STARRS publications can be found at
http://www.ARMYSTARRS.org. As a cooperative agreement, scientists
employed by NIMH (L. J. Colpe and M. Schoenbaum) and Army
liaisons/consultants (Col. Steven Cersovsky, MD, MPH USAPHC and Kenneth
Cox, MD, MPH USAPHC) collaborated to develop the study protocol and data
collection instruments, supervise data collection, plan and supervise
data analyses, interpret results, and prepare reports.; Although a draft
of this manuscript was submitted to the Army and NIMH for review and
comment prior to submission, this was with the understanding that
comments would be no more than advisory.
NR 46
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U2 18
PU CAMBRIDGE UNIV PRESS
PI NEW YORK
PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA
SN 0033-2917
EI 1469-8978
J9 PSYCHOL MED
JI Psychol. Med.
PD MAR
PY 2015
VL 45
IS 4
BP 717
EP 726
DI 10.1017/S003329171400258X
PG 10
WC Psychology, Clinical; Psychiatry; Psychology
SC Psychology; Psychiatry
GA CB4SR
UT WOS:000349618900004
PM 25359554
ER
PT J
AU Lieberman, HR
Thompson, LA
Caruso, CM
Niro, PJ
Mahoney, CR
McClung, JP
Caron, GR
AF Lieberman, Harris R.
Thompson, Lauren A.
Caruso, Christina M.
Niro, Philip J.
Mahoney, Caroline R.
McClung, James P.
Caron, Gregory R.
TI The catecholamine neurotransmitter precursor tyrosine increases anger
during exposure to severe psychological stress
SO PSYCHOPHARMACOLOGY
LA English
DT Article
DE Mood; Cortisol; Amino acid; Norepinephrine; Dopamine; SERE;
Interrogation; Military
ID COGNITIVE PERFORMANCE; SALIVARY CORTISOL; NEUROPEPTIDE-Y; UNCONTROLLABLE
STRESS; SLEEP-DEPRIVATION; MOTOR-PERFORMANCE; ADRENAL-FUNCTION;
WORKING-MEMORY; COLD-EXPOSURE; MOOD
AB Acute stress produces behavioral and physiological changes modulated by central catecholamines (CA). Stress increases CA activity, and depletion of CA stores reduces responses to stress. Increasing CA activity by administration of the dietary amino acid CA precursor tyrosine may increase responsiveness to stress. This study determined whether tyrosine enhances the ability of humans to respond to severe stress.
Severe psychological stress was generated during training at Survival, Evasion, Resistance, and Escape (SERE) School. The acute stressor consisted of two mock interrogations conducted during several days of simulated captivity. Seventy-eight healthy male and female military personnel participated in this double-blind, between-subjects study, in which they received either tyrosine (300 mg/kg, N = 36) or placebo (N = 36). Tyrosine (or placebo) was administered in food bars in two doses of 150 mg/kg each approximately 60 min before each mock interrogation. Mood (Profile of Mood States), saliva cortisol, and heart rate (HR) were assessed prior to stress exposure during a week of academic training preceding mock captivity and immediately following the mock interrogations.
The severe stress produced robust effects on mood (i.e., increased tension, depression, anger, fatigue, vigor, and confusion; p < .001), cortisol, and HR (p < .001). Tyrosine increased anger (p = .002, ANOVA treatment condition by test session interaction) during stress but had no other effects.
Tyrosine did not alter most subjective or physiological responses to severe acute stress, but it increased ratings of anger. The modest increase in anger may be an adaptive emotional response in stressful environments.
C1 [Lieberman, Harris R.; Thompson, Lauren A.; Caruso, Christina M.; Niro, Philip J.; McClung, James P.] US Army Res Inst Environm Med, Mil Nutr Div, Natick, MA 01760 USA.
[Mahoney, Caroline R.] US Army Natick Soldier Res Dev & Engn Ctr, Natick, MA 01760 USA.
[Caron, Gregory R.] SERE EAST, Ctr Secur Forces, Brunswick, ME 04011 USA.
RP Lieberman, HR (reprint author), US Army Res Inst Environm Med, Mil Nutr Div, Kansas St, Natick, MA 01760 USA.
EM harris.lieberman@us.army.mil
FU US Army Medical Research and Materiel Command
FX The authors wish to acknowledge the volunteers that participated in the
present study as well as the staff at the US Navy SERE School in
Brunswick, ME, for allowing access to their students and facilities. The
authors would also like to thank Jack Briggs and Paul Maguire for their
assistance with the development and preparation of the food bars used in
this study and Phil Karl, Tony Rogers, Mike Stanger, and Brooke Green
for their assistance with data collection. The opinions or assertions
contained herein are the private views of the authors and are not to be
construed as official or as reflecting the views of the US Army or
Department of Defense. Human subjects participated in these studies
after giving their free and informed voluntary consent. The
investigators have adhered to the policies for the protection of human
subjects as prescribed in Army Regulation 70-25, and the research was
conducted in adherence with the provisions of 32 CFR Part 219. Citations
of commercial organizations and trade names in this report do not
constitute an official US Department of the Army endorsement or approval
of the products or services of these organizations. This study was
supported by the US Army Medical Research and Materiel Command.
NR 64
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U2 11
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0033-3158
EI 1432-2072
J9 PSYCHOPHARMACOLOGY
JI Psychopharmacology
PD MAR
PY 2015
VL 232
IS 5
BP 943
EP 951
DI 10.1007/s00213-014-3727-7
PG 9
WC Neurosciences; Pharmacology & Pharmacy; Psychiatry
SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry
GA CB1HD
UT WOS:000349377000011
PM 25220844
ER
PT J
AU Muhandiramge, D
Udeoji, DU
Biswas, OS
Bharadwaj, P
Black, LZ
Mulholland, KA
Moschella, C
Schwarz, ER
AF Muhandiramge, Demian
Udeoji, Dioma U.
Biswas, Olivia S.
Bharadwaj, Parag
Black, Leila Z.
Mulholland, Karen Angelus
Moschella, Concetta
Schwarz, Ernst R.
TI Palliative care issues in heart transplant candidates
SO CURRENT OPINION IN SUPPORTIVE AND PALLIATIVE CARE
LA English
DT Review
DE chronic heart failure; heart transplant; palliative care; quality of
life
ID QUALITY-OF-LIFE; CONTROLLED-TRIAL; FAILURE PATIENTS; DISEASE;
BREATHLESSNESS; ASSOCIATION; PERCEPTIONS; MANAGEMENT; SERVICES; PAIN
AB Purpose of review
Heart failure is a serious condition and equivalent to malignant disease in terms of symptoms burden and mortality. Presently, only a comparatively small number of heart failure patients receive specialized palliative care. A literature search was conducted with the terms, palliative care and heart failure, using the electronic databases of PubMed and MEDLINE.
Recent findings
Nine-hundred and five articles were reviewed and of those, 78 articles discussed clinical trials in palliative care and heart failure. A complex set of management tools and strategies were used and recommended, including but not limited to lifestyle modification, exercise programs, pain and sleep disorder management, and support in end-of-life care. Limited data are available of using palliative care in heart transplant candidates prior to transplant surgery.
Summary
Diminishing quality of life prevails throughout the course of chronic heart failure. Therefore, palliative care should be integrated into heart failure management. Heart transplant candidates may benefit from early palliative care involvement independent of the clinical course and outcome. Because of gaps in current scientific literature on palliative care, end-of-life care, and hospice care and the services rendered, further research is necessary to encourage healthcare professionals to introduce palliative care as an early resource in chronic disease progression.
C1 [Muhandiramge, Demian; Udeoji, Dioma U.; Biswas, Olivia S.; Bharadwaj, Parag; Black, Leila Z.; Mulholland, Karen Angelus; Moschella, Concetta; Schwarz, Ernst R.] DSMI, Beverly Hills, CA USA.
[Muhandiramge, Demian; Udeoji, Dioma U.; Biswas, Olivia S.; Bharadwaj, Parag; Black, Leila Z.; Mulholland, Karen Angelus; Moschella, Concetta; Schwarz, Ernst R.] Cedars Sinai Med Ctr, Los Angeles, CA 90048 USA.
[Muhandiramge, Demian; Udeoji, Dioma U.; Biswas, Olivia S.; Bharadwaj, Parag; Black, Leila Z.; Mulholland, Karen Angelus; Moschella, Concetta; Schwarz, Ernst R.] St Joseph Hosp, USA, Chicago, IL USA.
RP Schwarz, ER (reprint author), Cedars Sinai Med Ctr, 8631 West Third St,Ste 1017 East Tower, Los Angeles, CA 90048 USA.
EM dr.ernstschwarz@gmail.com
NR 64
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U1 0
U2 6
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1751-4258
EI 1751-4266
J9 CURR OPIN SUPPORT PA
JI Curr. Opin Support Palliat. Car.
PD MAR
PY 2015
VL 9
IS 1
BP 5
EP 13
DI 10.1097/SPC.0000000000000112
PG 9
WC Health Care Sciences & Services
SC Health Care Sciences & Services
GA CA3UF
UT WOS:000348831600002
PM 25588206
ER
PT J
AU Suedel, BC
Clarke, JU
Wilkens, J
Lutz, CH
Clarke, DG
AF Suedel, Burton C.
Clarke, Joan U.
Wilkens, Justin
Lutz, Charles H.
Clarke, Douglas G.
TI The Effects of a Simulated Suspended Sediment Plume on Eastern Oyster
(Crassostrea virginica) Survival, Growth, and Condition
SO ESTUARIES AND COASTS
LA English
DT Article
DE Toxicity; Environmental windows; Dredging; James River; Condition index
ID SOFT-SHELL CLAM; MERCENARIA-MERCENARIA; VALVE GAPE; FOOD AVAILABILITY;
FEEDING-BEHAVIOR; BIVALVE BEHAVIOR; WATER-FLOW; MUSSELS; PREDATION;
TRANSPORT
AB Bottom sediments are resuspended into the water column during dredging operations. These resuspended sediments are an often cited concern used to justify restrictions applied to dredging schedules in many areas of the USA. One example of a temporal restriction, commonly referred to as an environmental window, involves dredging schedules in the James River, Virginia, because of potential impacts on the eastern oyster (Crassostrea virginica Gmelin). Yet, effects' data are lacking to understand the effects of suspended sediments to C. virginica. To address this data gap, we performed a laboratory study mimicking sediment resuspension during annual dredging operations in the James River. Field-collected oysters were exposed for 7 days under flow-through conditions to 0, 100, 250, and 500-mg/L total suspended solids (TSS) in a unique exposure system where oyster movements could be electronically monitored. Endpoints analyzed were survival, percent of time open, total number of shell movements, weight change, and condition index. Data indicated no significant effects of suspended sediment on these endpoints after 7 days of exposure. Weight change in oysters attached vertically to monitor their movements was significantly less than in oysters not monitored in every treatment. No significant differences in condition index, an indicator of oyster growth sensitive to environmental pollutants, were observed among treatments measured 30 days postexposure. Correlations performed for each treatment among monitored oyster endpoints found significant negative associations between number of movements and percent open in the 100, 250, and 500-mg/L TSS treatments and in all treatments combined. These data will help reduce the uncertainty surrounding the effects of suspended sediments on C. virginica.
C1 [Suedel, Burton C.; Clarke, Joan U.; Wilkens, Justin; Lutz, Charles H.; Clarke, Douglas G.] US Army Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA.
RP Suedel, BC (reprint author), US Army Engineer Res & Dev Ctr, Environm Lab, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA.
EM burton.suedel@usace.army.mil
FU Dredging Operations and Environmental Research Program
FX We thank Tom Kellum of W.E. Kellum, Inc. for the field collection of the
oysters. We thank Roger Mann of the Virginia Institute of Marine
Sciences (VIMS) for reviewing an earlier version of the paper. We thank
Sarah O'Haire of the Norfolk District Corps of Engineers for
coordinating sediment collection and Melissa Southworth of the VIMS for
providing holding facilities and for performing condition index
measurements. This research was funded by the Dredging Operations and
Environmental Research Program, Todd Bridges, Program Manager.
Permission was granted by the Chief of Engineers to publish this
material.
NR 69
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Z9 1
U1 3
U2 24
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1559-2723
EI 1559-2731
J9 ESTUAR COAST
JI Estuaries Coasts
PD MAR
PY 2015
VL 38
IS 2
BP 578
EP 589
DI 10.1007/s12237-014-9835-0
PG 12
WC Environmental Sciences; Marine & Freshwater Biology
SC Environmental Sciences & Ecology; Marine & Freshwater Biology
GA CA3EN
UT WOS:000348789300014
ER
PT J
AU Salzer, WL
Jones, TL
Devidas, M
Dreyer, ZE
Gore, L
Winick, NJ
Sung, L
Raetz, E
Loh, ML
Wang, CY
De Lorenzo, P
Valsecchi, MG
Pieters, R
Carroll, WL
Hunger, SP
Hilden, JM
Brown, P
AF Salzer, Wanda L.
Jones, Tamekia L.
Devidas, Meenakshi
Dreyer, ZoAnn E.
Gore, Lia
Winick, Naomi J.
Sung, Lillian
Raetz, Elizabeth
Loh, Mignon L.
Wang, Cindy Y.
De Lorenzo, Paola
Valsecchi, Maria Grazia
Pieters, Rob
Carroll, William L.
Hunger, Stephen P.
Hilden, Joanne M.
Brown, Patrick
TI Decreased Induction Morbidity and Mortality Following Modification to
Induction Therapy in Infants With Acute Lymphoblastic Leukemia Enrolled
on AALL0631: A Report From the Children's Oncology Group
SO PEDIATRIC BLOOD & CANCER
LA English
DT Article
DE infant acute lymphoblastic leukemia; mortality
ID FARBER-CANCER-INSTITUTE; STANDARD-RISK; CHILDHOOD-LEUKEMIA; CONSECUTIVE
TRIALS; PROGNOSTIC-FACTORS; IMPROVED SURVIVAL; RANDOMIZED-TRIAL;
DEXAMETHASONE; EXPERIENCE; PROTOCOL
AB BackgroundInfants with acute lymphoblastic leukemia (ALL) have a poor prognosis. Intensification of therapy has resulted in fewer relapses but increased early deaths, resulting in failure to improve survival.
ProcedureAALL0631 is a Phase 3 study for infants (<366 days of age) with newly diagnosed ALL. Induction initially (Cohort 1) consisted of 3 weeks of therapy based on COG P9407. Due to excessive early mortality, induction was amended to a less intensive 5 weeks of therapy based on Interfant-99. Additionally, enhanced supportive care guidelines were incorporated with hospitalization during induction until evidence of marrow recovery and recommendations for prevention/treatment of infections (Cohort 2).
ResultsInduction mortality was significantly lower for patients in Cohort 2 (2/123, 1.6%) versus Cohort 1 (4/26, 15.4%; P=0.009). All induction deaths were infection related except one due to progressive disease (Cohort 2). Sterile site infections were lower for patients in Cohort 2 (24/123, 19.5%) versus Cohort 1 (15/26, 57.7%; P=0.0002), with a significantly lower rate of Gram positive infections during induction for patients in Cohort 2, P=0.0002. No clinically significant differences in grades 3-5 non-infectious toxicities were observed between the two cohorts. Higher complete response rates were observed at end induction intensification for Cohort 2 (week 9, 94/100, 94%) versus Cohort 1 (week 7, 17/25, 68%; P=0.0.0012).
ConclusionDe-intensification of induction therapy and enhanced supportive care guidelines significantly decreased induction mortality and sterile site infections, without decreasing complete remission rates. Pediatr Blood Cancer 2015;62:414-418. (c) 2014 Wiley Periodicals, Inc.
C1 [Salzer, Wanda L.] US Army Med Res & Mat Command, Ft Detrick, MD USA.
[Jones, Tamekia L.; Devidas, Meenakshi] Univ Florida, Coll Med, Dept Biostat, Gainesville, FL USA.
[Jones, Tamekia L.; Devidas, Meenakshi] Univ Florida, Coll Publ Hlth & Hlth Profess, Dept Biostat, Gainesville, FL USA.
[Dreyer, ZoAnn E.] Baylor Coll Med, Texas Childrens Canc Ctr, Houston, TX 77030 USA.
[Gore, Lia; Hunger, Stephen P.; Hilden, Joanne M.] Univ Colorado Sch Med, Childrens Hosp Colorado, Aurora, CO USA.
[Winick, Naomi J.] Univ Texas Southwestern Sch Med, Div Pediat Hematol Oncol, Dallas, TX USA.
[Sung, Lillian] Hosp Sick Children, Div Haematol Oncol, Toronto, ON M5G 1X8, Canada.
[Raetz, Elizabeth] Univ Utah, Dept Pediat, Salt Lake City, UT USA.
[Raetz, Elizabeth] Univ Utah, Huntsman Canc Inst, Salt Lake City, UT USA.
[Loh, Mignon L.] Univ Calif San Francisco, Dept Pediat, San Francisco, CA USA.
[Wang, Cindy Y.] Univ Florida, Childrens Oncol Grp, Stat & Data Ctr, Gainesville, FL USA.
[De Lorenzo, Paola] Univ Milano Bicocca, Interfant Trial Data Ctr, Pediat Clin, Monza, Italy.
[De Lorenzo, Paola; Valsecchi, Maria Grazia] Univ Milano Bicocca, Dept Hlth Sci, Monza, Italy.
[Pieters, Rob] Erasmus MC Sophia Childrens Hosp, Princess Maxima Ctr Pediat Oncol, Rotterdam, Netherlands.
[Carroll, William L.] New York Univ Canc Inst, New York, NY USA.
[Brown, Patrick] Johns Hopkins Univ, Baltimore, MD USA.
RP Salzer, WL (reprint author), 1077 Patchel St, Ft Detrick, MD 21702 USA.
EM wanda.l.salzer.mil@mail.mil
FU National Institutes of Health [CA13539, CA98543]
FX Grant sponsor: National Institutes of Health; Grant number: CA13539 and
CA98543
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U1 1
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PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1545-5009
EI 1545-5017
J9 PEDIATR BLOOD CANCER
JI Pediatr. Blood Cancer
PD MAR
PY 2015
VL 62
IS 3
BP 414
EP 418
DI 10.1002/pbc.25311
PG 5
WC Oncology; Hematology; Pediatrics
SC Oncology; Hematology; Pediatrics
GA CA4BU
UT WOS:000348850100008
PM 25407157
ER
PT J
AU Chambers, C
Luo, CY
Tong, M
Yang, YR
Saxena, A
AF Chambers, Carolyn
Luo, Chunyuan
Tong, Min
Yang, Yerie
Saxena, Ashima
TI Probing the role of amino acids in oxime-mediated reactivation of nerve
agent-inhibited human acetylcholinesterase
SO TOXICOLOGY IN VITRO
LA English
DT Article
DE Human AChE mutants; Nerve agents; Oximes; Reactivation; In vitro study;
Site-directed mutagenesis
ID ORGANOPHOSPHORUS COMPOUNDS; CHOLINESTERASES; MECHANISM; VARIANTS;
RESIDUES; KINETICS; BIOLOGY; HI-6
AB In this study, we employed site-directed mutagenesis to understand the role of amino acids in the gorge in oxime-induced reactivation of nerve agent-inhibited human (Hu) acetylcholinesterase (AChE). The organophosphorus (OP) nerve agents studied included GA (tabun), GB (sarin), GF (cyclosarin), VX, and VR. The kinetics of reactivation were examined using both the mono-pyridinium oxime 2-PAM and bis-pyridinium oximes MMB4, HI-6, and HLo-7. The second-order reactivation rate constants were used to compare reactivation of nerve agent-inhibited wild-type (WT) and mutant enzymes. Residues including Y72, Y124 and W286 were found to play important roles in reactivation by bis-pyridinium, but not by mono-pyridinium oximes. Residue Y124 also was found to play a key role in reactivation by HI-6 and HLo-7, while E202 was important for reactivation by all oximes. Residue substitutions of F295 by Leu and Y337 by Ala showed enhanced reactivation by bis-pyridinium oximes MMB4, HI-6, and HLo-7, possibly by providing more accessibility of the OP moiety associated at the active-site serine to the oxime. These results are similar to those observed previously with bovine AChE and demonstrate that there is significant similarity between human and bovine AChEs with regard to oxime reactivation. Published by Elsevier Ltd.
C1 [Chambers, Carolyn; Luo, Chunyuan; Tong, Min; Yang, Yerie; Saxena, Ashima] Walter Reed Army Inst Res, Div Biochem, Silver Spring, MD 20910 USA.
[Saxena, Ashima] US Mil, HIV Res Program, Walter Reed Army Inst Res, Silver Spring, MD 20910 USA.
RP Saxena, A (reprint author), US Mil, HIV Res Program, Walter Reed Army Inst Res, Silver Spring, MD 20910 USA.
EM ashima.saxena@us.army.mil
FU Defense Threat Reduction Agency-Joint Science and Technology Office,
Medical Science and Technology Division
FX We wish to thank Dr. Oksana Lockridge of the University of Nebraska for
providing the plasmid carrying the full length cDNA sequence of Hu AChE,
and Richard Sweeney for the schematic representation of AChE. The views
expressed in this manuscript are those of the author(s) and do not
reflect the official policy of the Department of Army, Department of
Defense, or the U.S. Government. This research was supported by the
Defense Threat Reduction Agency-Joint Science and Technology Office,
Medical Science and Technology Division.
NR 34
TC 4
Z9 4
U1 3
U2 23
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0887-2333
J9 TOXICOL IN VITRO
JI Toxicol. Vitro
PD MAR
PY 2015
VL 29
IS 2
BP 408
EP 414
DI 10.1016/j.tiv.2014.11.001
PG 7
WC Toxicology
SC Toxicology
GA CA0RW
UT WOS:000348625200017
PM 25451328
ER
PT J
AU Dubick, MA
Barr, JL
Keen, CL
Atkins, JL
AF Dubick, Michael A.
Barr, Johnny L.
Keen, Carl L.
Atkins, James L.
TI Ceruloplasmin and Hypoferremia: Studies in Burn and Non-Burn Trauma
Patients
SO ANTIOXIDANTS
LA English
DT Article
DE ceruloplasmin; ferroxidase; iron status; oxidant stress; burn; trauma
ID RECOMBINANT-HUMAN-ERYTHROPOIETIN; RESPIRATORY-DISTRESS-SYNDROME; PARTIAL
THROMBOPLASTIN TIME; ACUTE LUNG INJURY; SMOKE-INHALATION;
IRON-METABOLISM; INFLAMMATORY RESPONSE; HYPERCOAGULABLE STATE;
HEMORRHAGIC-SHOCK; PROTHROMBIN TIME
AB Objective: Normal iron handling appears to be disrupted in critically ill patients leading to hypoferremia that may contribute to systemic inflammation. Ceruloplasmin (Cp), an acute phase reactant protein that can convert ferrous iron to its less reactive ferric form facilitating binding to ferritin, has ferroxidase activity that is important to iron handling. Genetic absence of Cp decreases iron export resulting in iron accumulation in many organs. The objective of this study was to characterize iron metabolism and Cp activity in burn and non-burn trauma patients to determine if changes in Cp activity are a potential contributor to the observed hypoferremia. Material and Methods: Under Brooke Army Medical Center Institutional Review Board approved protocols, serum or plasma was collected from burn and non-burn trauma patients on admission to the ICU and at times up to 14 days and measured for indices of iron status, Cp protein and oxidase activity and cytokines. Results: Burn patients showed evidence of anemia and normal or elevated ferritin levels. Plasma Cp oxidase activity in burn and trauma patients were markedly lower than controls on admission and increased to control levels by day 3, particularly in burn patients. Plasma cytokines were elevated throughout the 14 days study along with evidence of an oxidative stress. No significant differences in soluble transferrin receptor were noted among groups on admission, but levels in burn patients were lower than controls for the first 5 days after injury. Conclusion: This study further established the hypoferremia and inflammation associated with burns and trauma. To our knowledge, this is the first study to show an early decrease in Cp oxidase activity in burn and non-burn trauma patients. The results support the hypothesis that transient loss of Cp activity contributes to hypoferremia and inflammation. Further studies are warranted to determine if decreased Cp activity increases the risk of iron-induced injury following therapeutic interventions such as transfusions with blood that has undergone prolonged storage in trauma resuscitation.
C1 [Dubick, Michael A.; Barr, Johnny L.] US Army, Inst Surg Res, 3698 Chambers Pass, JBSA Ft Sam Houston, TX 78234 USA.
[Keen, Carl L.] Univ Calif Davis, Dept Nutr & Internal Med, Davis, CA 95616 USA.
[Atkins, James L.] Walter Reed Army Inst Res, Silver Spring, MD 20910 USA.
RP Dubick, MA (reprint author), US Army, Inst Surg Res, 3698 Chambers Pass, JBSA Ft Sam Houston, TX 78234 USA.
EM michael.a.dubick.civ@mail.mil; Johnny.l.barr.civ@mail.mil;
clkeen@ucdavis.edu; jim.atkins.w@gmail.com
NR 57
TC 0
Z9 0
U1 1
U2 1
PU MDPI AG
PI BASEL
PA POSTFACH, CH-4005 BASEL, SWITZERLAND
SN 2076-3921
J9 ANTIOXIDANTS
JI Antioxidants
PD MAR
PY 2015
VL 4
IS 1
BP 153
EP 169
DI 10.3390/antiox4010153
PG 17
WC Chemistry, Medicinal
SC Pharmacology & Pharmacy
GA DG0XO
UT WOS:000371789500009
PM 26785343
ER
PT J
AU Kearney, SP
Mosca, VS
AF Kearney, Sean P.
Mosca, Vincent S.
TI Selective hemiepiphyseodesis for patellar instability with associated
genu valgum
SO JOURNAL OF ORTHOPAEDICS
LA English
DT Article
DE Patellar instability; Genu valgum; Epiphyseodesis; Guided growth
ID MEDIAL PATELLOFEMORAL LIGAMENT; DISLOCATION; CHILDREN; RECONSTRUCTION;
KNEE; REALIGNMENT; VARUM; PAIN
AB Background/Aims: Patellar instability limits activity and promotes arthritis. Correcting genu valgum with selective hemiepiphyseodesis can treat patellar instability.
Methods: We retrospectively reviewed 26 knees with patellar instability and associated genu valgum that underwent hemiepiphyseodesis.
Results: Average anatomic lateral distal femoral angle (aLDFA) significantly corrected. Symptoms improved in all patients. All competitive athletes returned to sports. One complication occurred.
Conclusions: In genu valgum, the patella seeks an abnormal mechanical axis, resulting in patellar instability. By correcting the mechanical axis with hemiepiphyseodesis, patellar instability symptoms improve and patients return to sports. Complications are rare. Selective hemiepiphyseodesis is recommended when treating patellar instability with associated genu valgum. Copyright (C) 2015, Professor P K Surendran Memorial Education Foundation. Publishing Services by Reed Elsevier India Pvt. Ltd. All rights reserved.
C1 [Kearney, Sean P.] Womack Army Med Ctr, Dept Orthoped & Rehabil, Ft Bragg, NC 28310 USA.
[Mosca, Vincent S.] Seattle Childrens Hosp, Orthopaed Adm W 7706, Seattle, WA 98105 USA.
RP Kearney, SP (reprint author), Womack Army Med Ctr, Dept Orthoped & Rehabil, Ft Bragg, NC 28310 USA.
EM spkearney1@gmail.com
NR 29
TC 0
Z9 0
U1 0
U2 1
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0972-978X
J9 J ORTHOP
JI J. Orthop.
PD MAR
PY 2015
VL 12
IS 1
BP 17
EP 22
DI 10.1016/j.jor.2015.01.005
PG 6
WC Orthopedics
SC Orthopedics
GA DY9DX
UT WOS:000385434900004
PM 25829756
ER
PT J
AU Walling, K
AF Walling, Karl
TI American Force: Dangers, Delusions, and Dilemmas of National Security
SO NAVAL WAR COLLEGE REVIEW
LA English
DT Book Review
C1 [Walling, Karl] US Army, Adelphi, MD USA.
[Walling, Karl] Naval War Coll, Newport, RI USA.
NR 1
TC 0
Z9 0
U1 0
U2 0
PU US NAVAL WAR COLL
PI NEWPORT
PA 686 CUSHING RD, NEWPORT, RI 02841 USA
SN 0028-1484
J9 NAV WAR COLL REV
JI Nav. War Coll. Rev.
PD SPR
PY 2015
VL 68
IS 2
BP 131
EP 133
PG 3
WC International Relations
SC International Relations
GA DP3ZM
UT WOS:000378435000010
ER
PT J
AU Fischer, RA
Valente, JJ
Guilfoyle, MP
AF Fischer, Richard A.
Valente, Jonathon J.
Guilfoyle, Michael P.
TI SPRING MIGRANT USE OF NATIVE AND SALTCEDAR-DOMINATED RIPARIAN AREAS
ALONG THE LOWER COLORADO RIVER IN ARIZONA
SO SOUTHWESTERN NATURALIST
LA English
DT Article
ID SOUTHWESTERN UNITED-STATES; MIGRATORY SONGBIRD; LANDBIRD MIGRATION;
STOPOVER HABITAT; TAMARIX; BIRDS; PHYSIOGNOMY; COMMUNITIES; POPULATIONS;
FLORISTICS
AB Riparian systems in the western United States provide essential stopover habitat to en-route migrant birds, and there is concern that the invasion and dominance of saltcedar (Tamarix) in many areas may inhibit use by some species. However, evidence from recent studies is challenging the widely held belief that invasive plants universally reduce habitat quality. Moreover, where many studies have compared avian use of riparian habitats dominated by saltcedar with those comprised primarily of native trees, few have investigated how birds use shrub communities, which are becoming more prevalent in western riparian zones because of widespread hydrologic modifications. We compared spring migrant use of 125-m sections of riparian habitat dominated by five different habitat types in southwestern Arizona in 2006 and 2007. We found that migrant abundance, species richness, and community assemblages were all influenced by the composition of riparian vegetation. Habitats completely dominated by saltcedar supported fewer migrants and migrant species than any other habitat type, but the presence of small amounts of native vegetation as a part of the overall riparian plant community greatly bolstered habitat use. Habitats dominated by native shrubs tended to support the greatest total migrant abundance, total species richness, and abundance of many individual species. Our findings suggest that riparian areas dominated by saltcedar are avoided by many western migrant species and have relatively low value as stopover habitat. In places where this species is a predominant component of the riparian plant community, restoration of at least a portion of native riparian vegetation may be effective for encouraging use by stopover migrants.
C1 [Fischer, Richard A.; Valente, Jonathon J.; Guilfoyle, Michael P.] US Army, Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA.
RP Valente, JJ (reprint author), Oregon State Univ, Dept Forest Ecosyst & Soc, Corvallis, OR 97333 USA.
EM Jonathon.J.Valente@gmail.com
FU Department of Defense's Strategic Environmental Research and Development
Program [RC-1439]
FX We thank S.A. Gauthreaux Jr. for assistance in analyzing radar data, M.
D. Kaller for providing advice regarding statistical analyses, and N.
Volpe and G. Emmanuelli for translating the abstract. We also thank M.
T. Auer, C. Cordy, A. Larned, and J. McCabe for their assistance in the
field. This research was funded by the Department of Defense's Strategic
Environmental Research and Development Program as project RC-1439.
NR 37
TC 0
Z9 0
U1 3
U2 7
PU SOUTHWESTERN ASSOC NATURALISTS
PI SAN MARCOS
PA SOUTHWEST TEXAS STATE UNIV, DEPT BIOLOGY, 601 UNIVERSITY DR, SAN MARCOS,
TX 78666 USA
SN 0038-4909
EI 1943-6262
J9 SOUTHWEST NAT
JI Southw. Natural.
PD MAR
PY 2015
VL 60
IS 1
BP 6
EP 14
DI 10.1894/MCG-06.1
PG 9
WC Biodiversity Conservation; Ecology
SC Biodiversity & Conservation; Environmental Sciences & Ecology
GA DE8NQ
UT WOS:000370893200002
ER
PT J
AU Schill, JF
Holthoff, EL
Pellegrino, PM
AF Schill, John F.
Holthoff, Ellen L.
Pellegrino, Paul M.
TI Predicting the Resonant Frequency of Photoacoustic Cells With Side
Branches
SO IEEE SENSORS JOURNAL
LA English
DT Article
DE Acoustic resonance; photoacoustic cell; photoacoustic spectroscopy;
cylindrical tube with side branch
ID QUANTUM CASCADE LASER; SPECTROSCOPY
AB A theoretical method for predicting the resonant frequencies of acoustic resonators with side branches is introduced. This method is successfully extended to microelectromechanical-scale photoacoustic cell resonators with complex side branch structures. Resonant frequencies are calculated to within a few percent of experimental results. The effect of the side branch hole diameter on the resonant frequency is also demonstrated.
C1 [Schill, John F.; Holthoff, Ellen L.; Pellegrino, Paul M.] US Army Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA.
RP Schill, JF (reprint author), US Army Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA.
EM john.f.schill.civ@mail.mil; ellen.l.holthoff.civ@mail.mil;
paul.m.pellegrino.civ@mail.mil
NR 8
TC 3
Z9 3
U1 0
U2 19
PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
PI PISCATAWAY
PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA
SN 1530-437X
EI 1558-1748
J9 IEEE SENS J
JI IEEE Sens. J.
PD MAR
PY 2015
VL 15
IS 3
BP 1336
EP 1337
DI 10.1109/JSEN.2014.2369254
PG 2
WC Engineering, Electrical & Electronic; Instruments & Instrumentation;
Physics, Applied
SC Engineering; Instruments & Instrumentation; Physics
GA AX1ZS
UT WOS:000346743600004
ER
PT J
AU Wang, ZY
Nasrabadi, NM
Huang, TS
AF Wang, Zhangyang
Nasrabadi, Nasser M.
Huang, Thomas S.
TI Semisupervised Hyperspectral Classification Using Task-Driven Dictionary
Learning With Laplacian Regularization
SO IEEE TRANSACTIONS ON GEOSCIENCE AND REMOTE SENSING
LA English
DT Article
DE Bilevel optimization; hyperspectral image classification; semisupervised
learning; sparse coding; spatial Laplacian regularization; task-driven
dictionary learning
ID SUPPORT VECTOR MACHINES; IMAGE CLASSIFICATION; SPARSE-REPRESENTATION;
K-SVD
AB We present a semisupervised method for single-pixel classification of hyperspectral images. The proposed method is designed to address the special problematic characteristics of hyperspectral images, namely, high dimensionality of hyperspectral pixels, lack of labeled samples, and spatial variability of spectral signatures. To alleviate these problems, the proposed method features the following components. First, being a semisupervised approach, it exploits the wealth of unlabeled samples in the image by evaluating the confidence probability of the predicted labels, for each unlabeled sample. Second, we propose to jointly optimize the classifier parameters and the dictionary atoms by a task-driven formulation, to ensure that the learned features (sparse codes) are optimal for the trained classifier. Finally, it incorporates spatial information through adding a Laplacian smoothness regularization to the output of the classifier, rather than the sparse codes, making the spatial constraint more flexible. The proposed method is compared with a few comparable methods for classification of several popular data sets, and it produces significantly better classification results.
C1 [Wang, Zhangyang; Huang, Thomas S.] Univ Illinois, Dept Elect & Comp Engn, Beckman Inst, Champaign, IL 61801 USA.
[Nasrabadi, Nasser M.] US Army Res Lab, Adelphi, MD 20783 USA.
RP Wang, ZY (reprint author), Univ Illinois, Dept Elect & Comp Engn, Beckman Inst, Champaign, IL 61801 USA.
FU U.S. Army Research Laboratory; U.S. Army Research Office
[W911NF-09-1-0383]
FX The work was supported by the U.S. Army Research Laboratory and the U.S.
Army Research Office under Grant W911NF-09-1-0383.
NR 41
TC 6
Z9 6
U1 1
U2 44
PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
PI PISCATAWAY
PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA
SN 0196-2892
EI 1558-0644
J9 IEEE T GEOSCI REMOTE
JI IEEE Trans. Geosci. Remote Sensing
PD MAR
PY 2015
VL 53
IS 3
BP 1161
EP 1173
DI 10.1109/TGRS.2014.2335177
PG 13
WC Geochemistry & Geophysics; Engineering, Electrical & Electronic; Remote
Sensing; Imaging Science & Photographic Technology
SC Geochemistry & Geophysics; Engineering; Remote Sensing; Imaging Science
& Photographic Technology
GA AR9MZ
UT WOS:000343900600003
ER
PT J
AU Romeiser, R
Graber, HC
Caruso, MJ
Jensen, RE
Walker, DT
Cox, AT
AF Romeiser, Roland
Graber, Hans C.
Caruso, Michael J.
Jensen, Robert E.
Walker, David T.
Cox, Andrew T.
TI A New Approach to Ocean Wave Parameter Estimates From C-Band ScanSAR
Images
SO IEEE TRANSACTIONS ON GEOSCIENCE AND REMOTE SENSING
LA English
DT Article
DE Image analysis; remote sensing; synthetic aperture radar (SAR); waves;
wind
ID SYNTHETIC-APERTURE RADAR; BACKSCATTERING CROSS-SECTION; A SATELLITE
SCATTEROMETER; COMPOSITE SURFACE MODEL; SAR IMAGERY; WIND VECTOR;
SPECTRUM; POLARIZATION; INVERSION; PERFORMANCE
AB Because of their large swath widths of about 400-500 km, the ScanSAR modes of RADARSAT-1 and -2 and of the Advanced SAR (ASAR) system on Envisat have been the preferred modes of operation for hurricane and typhoon observations and similar applications. While C-band ScanSAR images have been demonstrated to be well suitable for wind retrievals, ocean wave retrievals are a more challenging problem: Because of the limited spatial resolution of 100 m (RADARSAT) / 150 m (Envisat), only long waves can get imaged directly, and many images of tropical storm scenarios do not exhibit clear signatures of any waves in large areas. The interpretation of wave patterns that exist in an image is difficult because of the imaging mechanism's nonlinearities. We think we have found a promising new technique for wave parameter retrievals from C-band ScanSAR images, which determines peak wavelengths and directions from image spectra where possible but uses an empirically determined relation to estimate significant wave heights (SWHs) from local mean image intensities, which is similar to the method used for wind retrievals. This way, it is possible to obtain SWH estimates for the entire image and to account for the contributions of subresolution-scale waves. We explain how the algorithm works and how the empirical SWH model function has been determined from a set of hurricane images from RADARSAT-1 and reference wave spectra from a numerical wave model. The first independent test with a set of RADARSAT-2 and Envisat images from the 2010 Impact of Typhoons on the Ocean in the Pacific (ITOP) experiment reveals a few weaknesses but essentially confirms the feasibility of the concept.
C1 [Romeiser, Roland] Univ Miami, Rosenstiel Sch Marine & Atmospher Sci, Dept Ocean Sci, Miami, FL 33149 USA.
[Graber, Hans C.] Univ Miami, Dept Ocean Sci, Miami, FL 33177 USA.
[Graber, Hans C.; Caruso, Michael J.] Univ Miami, Rosenstiel Sch Marine & Atmospher Sci, Ctr Southeastern Trop Adv Remote Sensing, Miami, FL 33177 USA.
[Jensen, Robert E.] US Army Corps Engineers, Coastal & Hydraul Lab, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA.
[Walker, David T.] SRI Int, Ann Arbor, MI 48105 USA.
[Cox, Andrew T.] Oceanweather Inc, Cos Cob, CT 06807 USA.
RP Romeiser, R (reprint author), Univ Miami, Rosenstiel Sch Marine & Atmospher Sci, Dept Ocean Sci, 4600 Rickenbacker Causeway, Miami, FL 33149 USA.
EM rromeiser@rsmas.miami.edu; hgraber@rsmas.miami.edu;
mcaruso@rsmas.miami.edu; Robert.E.Jensen@erdc.dren.mil;
david.walker@sri.com; andrewc@oceanweather.com
FU U.S. Office of Naval Research (ONR) [N00014-08-1-0581]; ONR
[N00014-09-C-0530]
FX This work was supported by the U.S. Office of Naval Research (ONR) under
Grant N00014-08-1-0581. The work of D. T. Walker was supported by the
ONR under Grant N00014-09-C-0530.
NR 55
TC 4
Z9 4
U1 2
U2 30
PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
PI PISCATAWAY
PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA
SN 0196-2892
EI 1558-0644
J9 IEEE T GEOSCI REMOTE
JI IEEE Trans. Geosci. Remote Sensing
PD MAR
PY 2015
VL 53
IS 3
BP 1320
EP 1345
DI 10.1109/TGRS.2014.2337663
PG 26
WC Geochemistry & Geophysics; Engineering, Electrical & Electronic; Remote
Sensing; Imaging Science & Photographic Technology
SC Geochemistry & Geophysics; Engineering; Remote Sensing; Imaging Science
& Photographic Technology
GA AR9MZ
UT WOS:000343900600016
ER
PT J
AU Barnes, TA
Kaminski, JW
Borodin, O
Miller, TF
AF Barnes, Taylor A.
Kaminski, Jakub W.
Borodin, Oleg
Miller, Thomas F., III
TI Ab lnitio Characterization of the Electrochemical Stability and
Solvation Properties of Condensed-Phase Ethylene Carbonate and Dimethyl
Carbonate Mixtures
SO JOURNAL OF PHYSICAL CHEMISTRY C
LA English
DT Article
ID DENSITY-FUNCTIONAL-THEORY; LITHIUM-ION BATTERIES; ORGANIC
ELECTROLYTE-SOLUTIONS; INITIO MOLECULAR-DYNAMICS; TRANSFER
EXCITED-STATES; MANY-BODY EXPANSION; PROPYLENE CARBONATE; OXIDATION
POTENTIALS; NONAQUEOUS ELECTROLYTES; QUANTUM-CHEMISTRY
AB A central challenge in the refinement of lithium-ion batteries is to control cathode-induced oxidative decomposition of electrolyte solvents, such as ethylene carbonate (EC) and dimethyl carbonate (DMC). We study the oxidation potentials of neat EC, neat DMC, and 1:1 mixtures of EC and DMC using the newly developed projection-based embedding method, which we demonstrate to be capable of correcting qualitative inaccuracies in the electronic densities and ionization energies obtained from conventional Kohn-Sham density functional theory (DFT) methods. Our wave function-in-DFT embedding approach enables accurate calculation of the vertical ionization energy (IE) of individual molecules at the CCSD(T) level of theory while explicitly accounting for the solvent using a combination of DFT and molecular mechanics interactions. We find that the ensemble-averaged distributions of vertical IEs are consistent with a linear response interpretation of the statistics of the solvent configurations, enabling determination of both the intrinsic oxidation potential of the solvents and the corresponding solvent reorganization energies. Interestingly, we reveal that large contributions to the solvation properties of DMC originate from quadrupolar interactions, resulting in a much larger solvent reorganization energy than that predicted using simple dielectric continuum models. Demonstration that the solvation properties of EC and DMC are governed by fundamentally different intermolecular interactions provides insight into key aspects of lithium-ion batteries, with relevance to electrolyte decomposition processes, solidelectrolyte interphase formation, and the local solvation environment of lithium cations.
C1 [Barnes, Taylor A.; Miller, Thomas F., III] CALTECH, Div Chem & Chem Engn, Pasadena, CA 91125 USA.
[Kaminski, Jakub W.] Univ Calif Los Angeles, Dept Math, Los Angeles, CA 90095 USA.
[Borodin, Oleg] US Army Res Lab, Electrochem Branch, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA.
RP Miller, TF (reprint author), CALTECH, Div Chem & Chem Engn, Pasadena, CA 91125 USA.
EM tfm@caltech.edu
RI Borodin, Oleg/B-6855-2012
OI Borodin, Oleg/0000-0002-9428-5291
FU Office of Naval Research (ONR) [N00014-10-1-0884]; U.S. Army Research
Laboratory; U.S. Army Research Office (USARO) [W911NF-10-1-0202]
FX This work is supported by the Office of Naval Research (ONR) under Grant
No. N00014-10-1-0884 and by the U.S. Army Research Laboratory and the
U.S. Army Research Office (USARO) under Grant No. W911NF-10-1-0202.
Computing resources were provided by the National Energy Research
Scientific Computing Center (NERSC) (DE-AC02-05CH11231).
NR 138
TC 19
Z9 19
U1 3
U2 51
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 1932-7447
J9 J PHYS CHEM C
JI J. Phys. Chem. C
PD FEB 26
PY 2015
VL 119
IS 8
BP 3865
EP 3880
DI 10.1021/jp510882g
PG 16
WC Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science,
Multidisciplinary
SC Chemistry; Science & Technology - Other Topics; Materials Science
GA CC4NE
UT WOS:000350329300001
ER
PT J
AU Ayithan, N
Bradfute, SB
Anthony, SM
Stuthman, KS
Bavari, S
Bray, M
Ozato, K
AF Ayithan, Natarajan
Bradfute, Steven B.
Anthony, Scott M.
Stuthman, Kelly S.
Bavari, Sina
Bray, Mike
Ozato, Keiko
TI Virus-Like Particles Activate Type I Interferon Pathways to Facilitate
Post-Exposure Protection against Ebola Virus Infection
SO PLOS ONE
LA English
DT Article
ID NF-KAPPA-B; DENDRITIC CELLS REQUIRES; TOLL-LIKE RECEPTOR; FILOVIRUS
INFECTION; REGULATORY FACTOR-8; HEMORRHAGIC-FEVER; INFLAMMASOME
ACTIVATION; CYTOKINE EXPRESSION; NEGATIVE REGULATION; IMMUNE-RESPONSES
AB Ebola virus (EBOV) causes a severe hemorrhagic disease with high fatality. Virus-like particles (VLPs) are a promising vaccine candidate against EBOV. We recently showed that VLPs protect mice from lethal EBOV infection when given before or after viral infection. To elucidate pathways through which VLPs confer post-exposure protection, we investigated the role of type I interferon (IFN) signaling. We found that VLPs lead to accelerated induction of IFN stimulated genes (ISGs) in liver and spleen of wild type mice, but not in Ifnar(-/-)mice. Accordingly, EBOV infected Ifnar(-/-)mice, unlike wild type mice succumbed to death even after VLP treatment. The ISGs induced in wild type mice included anti-viral proteins and negative feedback factors known to restrict viral replication and excessive inflammatory responses. Importantly, proinflammatory cytokine/chemokine expression was much higher in WT mice without VLPs than mice treated with VLPs. In EBOV infected Ifnar(-/-)mice, however, uninhibited viral replication and elevated proinflammatory factor expression ensued, irrespective of VLP treatment, supporting the view that type I IFN signaling helps to limit viral replication and attenuate inflammatory responses. Further analyses showed that VLP protection requires the transcription factor, IRF8 known to amplify type I IFN signaling in dendritic cells and macrophages, the probable sites of initial EBOV infection. Together, this study indicates that VLPs afford post-exposure protection by promoting expeditious initiation of type I IFN signaling in the host.
C1 [Ayithan, Natarajan; Ozato, Keiko] NICHHD, Program Genom Differentiat, NIH, Bethesda, MD 20892 USA.
[Bradfute, Steven B.; Anthony, Scott M.; Stuthman, Kelly S.; Bavari, Sina] US Army, Med Inst Infect Dis, Ft Detrick, MD USA.
[Bray, Mike] NIAID, Integrated Res Facil, NIH, Ft Detrick, MD USA.
RP Ozato, K (reprint author), NICHHD, Program Genom Differentiat, NIH, Bethesda, MD 20892 USA.
EM ozatok@nih.gov
FU Intramural Program of NICHD; Trans-NIH FDA intramural Bio-defense
Program, NIH
FX This work was supported by the Intramural Program of NICHD and the
Trans-NIH FDA intramural Bio-defense Program, NIH. The funders had no
role in study design, data collection and analysis, decision to publish,
or preparation of the manuscript.
NR 58
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PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD FEB 26
PY 2015
VL 10
IS 2
AR UNSP e0118345
DI 10.1371/journal.pone.0118345
PG 17
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA CC2ZH
UT WOS:000350213200048
PM 25719445
ER
PT J
AU Huang, YM
Rueda, LM
AF Huang, Yiau-Min
Rueda, Leopoldo M.
TI Pictorial Keys to the Species of the Subgenera Albuginosus and
Aedimorphus (Grjebinei and Apicoannulatus Groups) of the Genus Aedes
Meigen in the Afrotropical Region (Diptera: Culicidae)
SO ZOOTAXA
LA English
DT Article
DE Culicidae; mosquitoes; identification key; Africa
ID ALLIED TAXA DIPTERA; LIFE STAGES; MORPHOLOGICAL DATA; AEDINI DIPTERA;
CLASSIFICATION; PHYLOGENY; OCHLEROTATUS
AB Nine species of the subgenus Albuginosus, one species of the subgenus Aedimorphus Grjebinei Group and two species of the subgenus Aedimorphus Apicoannulatus Group of the genus Aedes Meigen in the Afrotropical Region are treated in three pictorial keys based on diagnostic morphological features.
C1 [Huang, Yiau-Min] Smithsonian Inst, Dept Entomol, Washington, DC 20013 USA.
[Rueda, Leopoldo M.] Walter Reed Army Inst Res, Walter Reed Biosystemat Unit, Entomol Branch, Silver Spring, MD 20910 USA.
RP Huang, YM (reprint author), Smithsonian Inst, Dept Entomol, POB 37012,MSC C1109,MRC 534, Washington, DC 20013 USA.
EM huangy@si.edu; ruedapol@si.edu
NR 27
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U1 0
U2 2
PU MAGNOLIA PRESS
PI AUCKLAND
PA PO BOX 41383, AUCKLAND, ST LUKES 1030, NEW ZEALAND
SN 1175-5326
EI 1175-5334
J9 ZOOTAXA
JI Zootaxa
PD FEB 26
PY 2015
VL 3925
IS 1
BP 25
EP 36
PG 12
WC Zoology
SC Zoology
GA CB9VN
UT WOS:000349981700002
PM 25781728
ER
PT J
AU Shen, J
Yin, W
Kondoh, K
Jones, TL
Kecskes, LJ
Yarmolenko, SN
Wei, Q
AF Shen, J.
Yin, W.
Kondoh, K.
Jones, Tyrone L.
Kecskes, L. J.
Yarmolenko, S. N.
Wei, Q.
TI Mechanical behavior of a lanthanum-doped magnesium alloy at different
strain rates
SO MATERIALS SCIENCE AND ENGINEERING A-STRUCTURAL MATERIALS PROPERTIES
MICROSTRUCTURE AND PROCESSING
LA English
DT Article
DE Mg alloy; Mechanical properties; Adiabatic shear band (ASB); Strain rate
sensitivity (SRS); High strain rate behavior
ID SOLIDIFICATION POWDER-METALLURGY; SEVERE PLASTIC-DEFORMATION;
SINGLE-CRYSTAL MAGNESIUM; HIGH-PRESSURE TORSION; ELEVATED-TEMPERATURES;
ROOM-TEMPERATURE; MICROSTRUCTURAL EVOLUTION; MATRIX COMPOSITES;
ULTRAFINE GRAIN; NONBASAL SLIP
AB The mechanical behavior of a lanthanum doped Mg alloy, AZXE7111, (Mg-7Al-1Zn-1Ca-1La, all in wt%) extruded at different temperatures has been investigated under both quasi-static (strain rate similar to 1 x 10(-3) s(-1)) and dynamic (strain rate similar to 4 x 10(3) s(-1)) compressive loading. Comparison has been made against the experimental results of two conventional Mg alloys, AZ91E and WE43. It was observed via transmission electron microscopy (TEM) that the nanoscale intermetallic compounds of Al2Ca and Al11La3, have presumably formed during the hot extrusion process. These compounds are believed to contribute significantly to the strength by reducing the grain size and acting as dislocation barriers. Additionally, twinning has been considered as the main mechanism for the higher strain hardening rate at high strain rates than that at low strain rates. It has been found that the ultimate strength of the alloy is only similar to 10% higher at dynamic loading rate than at quasi-static loading rate. Localized micro-shear fracture was observed and adiabatic shear mode was suggested by further examination of dynamically loaded specimens. The shear localization is further discussed in detail and it is suggested that reduced strain hardening rate is responsible for shear localization and subsequent fracture at both low and high strain rates. (C) 2014 Elsevier B.V. All rights reserved.
C1 [Shen, J.; Yin, W.; Wei, Q.] Univ N Carolina, Dept Mech Engn, Charlotte, NC 28223 USA.
[Shen, J.] Northwestern Polytech Univ, Sch Aeronaut, Xian 710072, Peoples R China.
[Kondoh, K.] Osaka Univ, Joining & Welding Res Inst, Osaka 5670047, Japan.
[Jones, Tyrone L.; Kecskes, L. J.] US Army Res Lab, WMRD, Aberdeen Proving Ground, MD 21005 USA.
[Yarmolenko, S. N.] N Carolina Agr & Tech State Univ, Dept Mech Engn, NSF ERC, Greensboro, NC 27411 USA.
RP Wei, Q (reprint author), Univ N Carolina, Dept Mech Engn, Charlotte, NC 28223 USA.
EM qwei@uncc.edu
RI Wei, Qiuming/B-7579-2008; Shen, Jianghua/C-2586-2013; Yarmolenko,
Sergey/E-6819-2017
OI Shen, Jianghua/0000-0003-1017-0698;
FU U.S. Army Research Laboratory [W911QX-08-0073]; China Scholarship
Council; National Natural Science Foundation of China [10932008]; 111
Project [B07050]
FX This work is supported by U.S. Army Research Laboratory under Contract
no. W911QX-08-0073. J. H. Shen would like to acknowledge the financial
support from China Scholarship Council, National Natural Science
Foundation of China (No. 10932008) and the 111 Project (No. B07050).
NR 79
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U1 3
U2 28
PU ELSEVIER SCIENCE SA
PI LAUSANNE
PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND
SN 0921-5093
EI 1873-4936
J9 MAT SCI ENG A-STRUCT
JI Mater. Sci. Eng. A-Struct. Mater. Prop. Microstruct. Process.
PD FEB 25
PY 2015
VL 626
BP 108
EP 121
DI 10.1016/j.msea.2014.12.061
PG 14
WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary;
Metallurgy & Metallurgical Engineering
SC Science & Technology - Other Topics; Materials Science; Metallurgy &
Metallurgical Engineering
GA CC2QI
UT WOS:000350189300015
ER
PT J
AU Farrington, HL
Edwards, CE
Guan, X
Carr, MR
Baerwaldt, K
Lance, RF
AF Farrington, Heather L.
Edwards, Christine E.
Guan, Xin
Carr, Matthew R.
Baerwaldt, Kelly
Lance, Richard F.
TI Mitochondrial Genome Sequencing and Development of Genetic Markers for
the Detection of DNA of Invasive Bighead and Silver Carp
(Hypophthalmichthys nobilis and H. molitrix) in Environmental Water
Samples from the United States
SO PLOS ONE
LA English
DT Article
ID EDNA; INFORMATION; PERSISTENCE
AB Invasive Asian bighead and silver carp (Hypophthalmichthys nobilis and H. molitrix) pose a substantial threat to North American aquatic ecosystems. Recently, environmental DNA (eDNA), genetic material shed by organisms into their environment that can be detected by non-invasive sampling strategies and genetic assays, has gained recognition as a tool for tracking the invasion front of these species toward the Great Lakes. The goal of this study was to develop new species-specific conventional PCR (cPCR) and quantitative (qPCR) markers for detection of these species in North American surface waters. We first generated complete mitochondrial genome sequences from 33 bighead and 29 silver carp individuals collected throughout their introduced range. These sequences were aligned with those from other common and closely related fish species from the Illinois River watershed to identify and design new species-specific markers for the detection of bighead and silver carp DNA in environmental water samples. We then tested these genetic markers in the laboratory for species-specificity and sensitivity. Newly developed markers performed well in field trials, did not have any false positive detections, and many markers had much higher detection rates and sensitivity compared to the markers currently used in eDNA surveillance programs. We also explored the use of multiple genetic markers to determine whether it would improve detection rates, results of which showed that using multiple highly sensitive markers should maximize detection rates in environmental samples. The new markers developed in this study greatly expand the number of species-specific genetic markers available to track the invasion front of bighead and silver carp and will improve the resolution of these assays. Additionally, the use of the qPCR markers developed in this study may reduce sample processing time and cost of eDNA monitoring for these species.
C1 [Farrington, Heather L.; Edwards, Christine E.; Guan, Xin; Carr, Matthew R.; Lance, Richard F.] United States Army, Engn Res & Dev Ctr, Environm Lab, Vicksburg, MS 39183 USA.
[Baerwaldt, Kelly] United States Army, Corps Engn, Rock Isl, IL USA.
RP Lance, RF (reprint author), United States Army, Engn Res & Dev Ctr, Environm Lab, Vicksburg, MS 39183 USA.
EM richard.f.lance@usace.army.mil
OI Edwards, Christine/0000-0001-8837-4872
FU Asian Carp Regional Coordinating Committee
FX Funding for this project was provided to KB and RFL by the Asian Carp
Regional Coordinating Committee (http://asiancarp.us). The funder had no
role in study design, data collection and analysis, decision to publish,
or preparation of the manuscript.
NR 34
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U1 9
U2 51
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD FEB 23
PY 2015
VL 10
IS 2
AR e0117803
DI 10.1371/journal.pone.0117803
PG 17
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA CC9BI
UT WOS:000350662100119
PM 25706532
ER
PT J
AU Johnston, SC
Briese, T
Bell, TM
Pratt, WD
Shamblin, JD
Esham, HL
Donnelly, GC
Johnson, JC
Hensley, LE
Lipkin, WI
Honko, AN
AF Johnston, Sara C.
Briese, Thomas
Bell, Todd M.
Pratt, William D.
Shamblin, Joshua D.
Esham, Heather L.
Donnelly, Ginger C.
Johnson, Joshua C.
Hensley, Lisa E.
Lipkin, W. Ian
Honko, Anna N.
TI Detailed Analysis of the African Green Monkey Model of Nipah Virus
Disease
SO PLOS ONE
LA English
DT Article
ID ENCEPHALITIS OUTBREAK; FLYING-FOXES; TRANSMISSION; HENIPAVIRUS;
INFECTION; BANGLADESH; PATHOLOGY; MALAYSIA; HENDRA; BATS
AB Henipaviruses are implicated in severe and frequently fatal pneumonia and encephalitis in humans. There are no approved vaccines or treatments available for human use, and testing of candidates requires the use of well-characterized animal models that mimic human disease. We performed a comprehensive and statistically-powered evaluation of the African green monkey model to define parameters critical to disease progression and the extent to which they correlate with human disease. African green monkeys were inoculated by the intratracheal route with 2.5x10(4) plaque forming units of the Malaysia strain of Nipah virus. Physiological data captured using telemetry implants and assessed in conjunction with clinical pathology were consistent with shock, and histopathology confirmed widespread tissue involvement associated with systemic vasculitis in animals that succumbed to acute disease. In addition, relapse encephalitis was identified in 100% of animals that survived beyond the acute disease phase. Our data suggest that disease progression in the African green monkey is comparable to the variable outcome of Nipah virus infection in humans.
C1 [Johnston, Sara C.; Pratt, William D.; Shamblin, Joshua D.; Esham, Heather L.; Donnelly, Ginger C.; Johnson, Joshua C.; Hensley, Lisa E.; Lipkin, W. Ian; Honko, Anna N.] US Army, Med Res Inst Infect Dis, Div Virol, Ft Detrick, MD 21702 USA.
[Briese, Thomas] Columbia Univ, Mailman Sch Publ Hlth, Ctr Infect & Immun, New York, NY USA.
[Bell, Todd M.] US Army, Med Res Inst Infect Dis, Div Pathol, Ft Detrick, MD 21702 USA.
RP Honko, AN (reprint author), Natl Inst Allergy & Infect Dis, Integrated Res Facil, 8200 Res Plaza, Ft Detrick, MD 21702 USA.
EM anna.honko@nih.gov
OI Johnson, Joshua/0000-0002-5677-3841; Honko, Anna/0000-0001-9165-148X
FU Northeast Biodefense Center [AI57158]; USAMRIID [1882367]
FX This work was supported by AI57158 (Northeast Biodefense Center) and
performed under USAMRIID project number 1882367. The funders had no role
in study design, data collection and analysis, decision to publish, or
preparation of the manuscript.
NR 30
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U1 0
U2 11
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD FEB 23
PY 2015
VL 10
IS 2
AR e0117817
DI 10.1371/journal.pone.0117817
PG 24
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA CC9BI
UT WOS:000350662100120
PM 25706617
ER
PT J
AU Sawe, FK
Obiero, E
Yegon, P
Langat, RC
Aoko, A
Tarus, J
Kiptoo, I
Langat, RK
Maswai, J
Bii, M
Khamadi, S
Shikuku, KP
Close, N
Sinei, S
Shaffer, DN
AF Sawe, Fredrick K.
Obiero, Eunice
Yegon, Peter
Langat, Rither C.
Aoko, Appolonia
Tarus, Jemutai
Kiptoo, Ignatius
Langat, Raphael K.
Maswai, Jonah
Bii, Margaret
Khamadi, Samoel
Shikuku, Kibet P.
Close, Nicole
Sinei, Samuel
Shaffer, Douglas N.
TI Kericho CLinic-Based ART Diagnostic Evaluation (CLADE): Design, Accrual,
and Baseline Characteristics of a Randomized Controlled Trial Conducted
in Predominately Rural, District-Level, HIV Clinics of Kenya
SO PLOS ONE
LA English
DT Article
ID ANTIRETROVIRAL TREATMENT FAILURE; VIRAL LOAD; COLLABORATIVE ANALYSIS;
VIROLOGICAL FAILURE; SOUTH-AFRICA; CELL COUNT; THERAPY; ROUTINE; COHORT;
ADULTS
AB Background
Prospective clinical trial data regarding routine HIV-1 viral load (VL) monitoring of antiretroviral therapy (ART) in non-research clinics of Sub-Saharan Africa are needed for policy makers.
Methods
CLinic-based ART Diagnostic Evaluation (CLADE) is a randomized, controlled trial (RCT) evaluating feasibility, superiority, and cost-effectiveness of routine VL vs. standard of care (clinical and immunological) monitoring in adults initiating dual nucleoside reverse transcriptase inhibitor (NRTI)+non-NRTI ART. Participants were randomized (1:1) at 7 predominately rural, non-research, district-level clinics of western Kenya. Descriptive statistics present accrual patterns and baseline cohort characteristics.
Results
Over 15 months, 820 adults enrolled at 7 sites with 86-152 enrolled per site. Monthly site enrollment ranged from 2-92 participants. Full (100%) informed consent compliance was independently documented. Half (49.9%) had HIV diagnosed through voluntary counseling and testing. Study arms were similar: mostly females (57.6%) aged 37.6 (SD = 9.0) years with low CD4 (166 [SD = 106]) cells/m(3)). Notable proportions had WHO Stage III or IV disease (28.7%), BMI < 18.5 kg/m(2) (23.1%), and a history of tuberculosis (5.6%) or were receiving tuberculosis treatment (8.2%) at ART initiation. In the routine VL arm, 407/409 (99.5%) received baseline VL (234,577 SD = 151,055 copies/ml). All participants received lamivudine; 49.8% started zidovudine followed by 38.4% stavudine and 11.8% tenofovir; and, 64.4% received nevirapine as nNRTI (35.6% efavirenz).
Conclusions
A RCT can be enrolled successfully in rural, non-research, resource limited, district-level clinics in western Kenya. Many adults presenting for ART have advanced HIV/AIDS, emphasizing the importance of universal HIV testing and linkage-to-care campaigns.
C1 [Sawe, Fredrick K.; Yegon, Peter; Langat, Rither C.; Aoko, Appolonia; Tarus, Jemutai; Kiptoo, Ignatius; Langat, Raphael K.; Maswai, Jonah; Bii, Margaret; Khamadi, Samoel; Shikuku, Kibet P.; Sinei, Samuel; Shaffer, Douglas N.] Kenya Govt Med Res Ctr, Walter Reed Project, Kericho, Kenya.
[Sawe, Fredrick K.; Shaffer, Douglas N.] US Mil HIV Res Program, Walter Reed Army Inst Res, Silver Spring, MD USA.
[Sawe, Fredrick K.] Henry M Jackson Fdn Adv Mil Med, Rockville, MD USA.
[Obiero, Eunice] Kenya Minist Publ Hlth & Sanitat, Kericho Dist Hosp, Kericho, Kenya.
[Yegon, Peter; Langat, Rither C.; Aoko, Appolonia; Tarus, Jemutai; Langat, Raphael K.; Maswai, Jonah; Bii, Margaret; Khamadi, Samoel; Sinei, Samuel] HJF Med Res Int Inc, Kericho, Kenya.
[Close, Nicole] EmpiriStat, Mt Airy, MD USA.
RP Sawe, FK (reprint author), Kenya Govt Med Res Ctr, Walter Reed Project, Kericho, Kenya.
EM Fredrick.Sawe@usamru-k.org
FU U.S. Office of the Global AIDS Coordinator [KE-07-0044]; Henry M.
Jackson Foundation for the Advancement of Military Medicine, Inc.
[W81XWH-07-2-0067]; U.S. Department of Defense (DOD) [W81XWH-07-2-0067,
W81XWH-07-2-0065]; Kenya Medical Research Institute [W81XWH-07-2-0065]
FX The Clinic-based ART Diagnostic Evaluation (CLADE) trial is sponsored by
the U.S. Office of the Global AIDS Coordinator (#KE-07-0044). This work
was also supported by a cooperative agreement (W81XWH-07-2-0067) between
the Henry M. Jackson Foundation for the Advancement of Military
Medicine, Inc., and the U.S. Department of Defense (DOD). Funding was
also received through a cooperative agreement (W81XWH-07-2-0065) between
the Kenya Medical Research Institute and the U.S. Department of Defense
(DOD). The funders had no role in study design, data collection and
analysis, decision to publish, or preparation of the manuscript.
NR 39
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PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD FEB 23
PY 2015
VL 10
IS 2
AR e0116299
DI 10.1371/journal.pone.0116299
PG 15
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA CC9BI
UT WOS:000350662100030
PM 25706652
ER
PT J
AU Shurtleff, AC
Whitehouse, CA
Ward, MD
Cazares, LH
Bavari, S
AF Shurtleff, Amy C.
Whitehouse, Chris A.
Ward, Michael D.
Cazares, Lisa H.
Bavari, Sina
TI Pre-symptomatic diagnosis and treatment of filovirus diseases
SO FRONTIERS IN MICROBIOLOGY
LA English
DT Review
DE Ebola; Marburg; diagnostics; therapeutics; zoonosis
ID EBOLA HEMORRHAGIC-FEVER; MEDIATED ISOTHERMAL AMPLIFICATION;
STOMATITIS-VIRUS VECTORS; NONHUMAN-PRIMATES; MARBURG VIRUS; RHESUS
MACAQUES; POSTEXPOSURE PROTECTION; CYNOMOLGUS MACAQUES; MORPHOLINO
OLIGOMERS; FAVIPIRAVIR T-705
AB Filoviruses are virulent human pathogens which cause severe illness with high case fatality rates and for which there are no available FDA-approved vaccines or therapeutics. Diagnostic tools including antibody- and molecular-based assays, mass spectrometry, and next-generation sequencing are continually under development. Assays using the polymerase chain reaction (PCR) have become the mainstay for the detection of filoviruses in outbreak settings. In many cases, real-time reverse transcriptase-PCR allows for the detection of filoviruses to be carried out with minimal manipulation and equipment and can provide results in less than 2 h. In cases of novel, highly diverse filoviruses, random-primed pyrosequencing approaches have proved useful. Ideally, diagnostic tests would allow for diagnosis of filovirus infection as early as possible after infection, either before symptoms begin, in the event of a known exposure or epidemiologic outbreak, or post-symptomatically. If tests could provide an early definitive diagnosis, then this information may be used to inform the choice of possible therapeutics. Several exciting new candidate therapeutics have been described recently; molecules that have therapeutic activity when administered to animal models of infection several days post-exposure, once signs of disease have begun. The latest data for candidate nucleoside analogs, small interfering RNA (siRNA) molecules, phosphorodiamidate (PMO) molecules, as well as antibody and blood-product therapeutics and therapeutic vaccines are discussed. For filovirus researchers and government agencies interested in making treatments available for a nation's defense as well as its general public, having the right diagnostic tools to identify filovirus infections, as well as a panel of available therapeutics for treatment when needed, is a high priority. Additional research in both areas is required for ultimate success, but significant progress is being made to reach these goals.
C1 [Shurtleff, Amy C.; Whitehouse, Chris A.; Ward, Michael D.; Cazares, Lisa H.; Bavari, Sina] US Army, Med Res Inst Infect Dis, Mol & Translat Sci Div, Ft Detrick, MD 21702 USA.
RP Bavari, S (reprint author), US Army, Med Res Inst Infect Dis, Mol & Translat Sci Div, 1425 Porter St, Ft Detrick, MD 21702 USA.
EM sina.bavari.civ@mail.mil
FU US Defense Threat Reduction Agency; Medical Countermeasures Systems
FX Opinions, interpretations, conclusions and recommendations are those of
the authors and are not necessarily endorsed by the US Army. The authors
would like to acknowledge funding from the US Defense Threat Reduction
Agency and Medical Countermeasures Systems. We also thank Trevor
Johnston for contributing the illustration of the man wearing a
biocontainment suit used in Figure 1.
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U1 1
U2 20
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA PO BOX 110, EPFL INNOVATION PARK, BUILDING I, LAUSANNE, 1015,
SWITZERLAND
SN 1664-302X
J9 FRONT MICROBIOL
JI Front. Microbiol.
PD FEB 20
PY 2015
VL 6
AR 108
DI 10.3389/fmicb.2015.00108
PG 13
WC Microbiology
SC Microbiology
GA CC4GT
UT WOS:000350311100001
PM 25750638
ER
PT J
AU Mc Aninch, IM
Palmese, GR
Lenhart, JL
La Scala, JJ
AF Mc Aninch, Ian M.
Palmese, Giuseppe R.
Lenhart, Joseph L.
La Scala, John J.
TI Epoxy-Amine Networks with Varying Epoxy Polydispersity
SO JOURNAL OF APPLIED POLYMER SCIENCE
LA English
DT Article
DE glass transition; mechanical properties; properties and
characterization; resins; thermosets
ID THERMAL-EXPANSION; FRACTURE-TOUGHNESS; RESINS; BEHAVIOR;
VISCOELASTICITY; COEFFICIENT; MECHANISMS; WEIGHTS; BLENDS
AB Solid, high molecular weight DGEBA-based epoxies were blended with high purity liquid DGEBA to create several resins with equivalent epoxy equivalent weights, but with polydispersity indices (PDIs) ranging from 3 to over 10. The resins were cured with a stoichiometric amount of polyetheramine and compared to a nonblended epoxy with PDI of 1.8. Modulus, glass transition temperatures, and molecular weight between cross-links were measured using dynamic mechanical analysis. Coefficients of thermal expansion (CTE) were measured and used to extend room temperature density measurements as a function of temperature. Fracture properties were also measured. Overall, the increased polydispersity has almost negligible effect, with the main difference occurring in the slope of the glassy CTE, with more polydisperse epoxies having a slower increase in CTE. In comparison to previous work where bimodal amines were blended with DGEBA, we conclude that epoxy resins are far more sensitive to distributions in the flexible portion, rather than the more rigid one. (c) 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015, 132, 41503.
C1 [Mc Aninch, Ian M.; La Scala, John J.] US Army, Res Lab, Attn RDRL WMM C, Aberdeen Proving Ground, MD 21005 USA.
[Mc Aninch, Ian M.; Palmese, Giuseppe R.] Drexel Univ, Dept Chem & Biol Engn, Philadelphia, PA 19104 USA.
[Lenhart, Joseph L.] US Army, Res Lab, Attn RDRL WMM G, Aberdeen Proving Ground, MD 21005 USA.
RP La Scala, JJ (reprint author), US Army, Res Lab, Attn RDRL WMM C, Aberdeen Proving Ground, MD 21005 USA.
EM john.j.lascala.civ@mail.mil
OI McAninch, Ian/0000-0002-9190-2936
FU US Army Research Laboratory under the Army Materials Center of
Excellence Program [W911NF-06-2-0013]; Oak Ridge Institute for Science
and Education
FX This research was supported in part by an appointment to the Student
Research Participation Program at the U.S. Army Research Laboratory
administered by the Oak Ridge Institute for Science and Education
through an interagency agreement between the U.S. Department of Energy
and USARL. Additional support was provided by the US Army Research
Laboratory under the Army Materials Center of Excellence Program,
Contract W911NF-06-2-0013.
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U1 1
U2 48
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0021-8995
EI 1097-4628
J9 J APPL POLYM SCI
JI J. Appl. Polym. Sci.
PD FEB 20
PY 2015
VL 132
IS 8
AR 41503
DI 10.1002/app.41503
PG 9
WC Polymer Science
SC Polymer Science
GA AU3LK
UT WOS:000345514500017
ER
PT J
AU Li, Z
Borodin, O
Smith, GD
Bedrov, D
AF Li, Zhe
Borodin, Oleg
Smith, Grant D.
Bedrov, Dmitry
TI Effect of Organic Solvents on Li+ Ion Solvation and Transport in Ionic
Liquid Electrolytes: A Molecular Dynamics Simulation Study
SO JOURNAL OF PHYSICAL CHEMISTRY B
LA English
DT Article
ID N-PROPYLPYRROLIDINIUM BIS(TRIFLUOROMETHANESULFONYL)IMIDE; LITHIUM ION;
ETHYLENE CARBONATE; SALT MIXTURES; RAMAN; ACETONITRILE; ASSOCIATION;
BATTERIES; CONDUCTIVITY; COORDINATION
AB Molecular dynamics simulations of N-methyl-N-propylpyrrolidinium (pyr(13)) bis(trifluoromethanesulfonyl)imide (Ntf(2)) ionic liquid [pyr(13)][Ntf(2)] doped with [Li][Ntf(2)] salt and mixed with acetonitrile (AN) and ethylene carbonate (EC) organic solvents were conducted using polarizable force field. Structural and transport properties of ionic liquid electrolytes (ILEs) with 20 and 40 mol % of organic solvents have been investigated and compared to properties of neat ILEs. Addition of AN and EC solvents to ILEs resulted in the partial displacement of the Ntf2 anions from the Li+ first coordination shell by EC and AN and shifting the LiNtf(2) coordination from bidentate to monodentate. The presence of organic solvents in ILE has increased the ion mobility, with the largest effect observed for the Li+ cation. The Li+ conductivity has doubled with addition of 40 mol % of AN. The Li(+)NNtf(2) residence times were dramatically reduced with addition of solvents, indicating an increasing contribution from structural diffusion of the Li+ cations.
C1 [Li, Zhe; Bedrov, Dmitry] Univ Utah, Dept Mat Sci & Engn, Salt Lake City, UT 84112 USA.
[Borodin, Oleg] Army Res Lab, Electrochem Branch, Adelphi, MD 20783 USA.
[Smith, Grant D.; Bedrov, Dmitry] Wasatch Mol Inc, Salt Lake City, UT 84103 USA.
RP Bedrov, D (reprint author), Univ Utah, Dept Mat Sci & Engn, 122 South Cent Campus Dr,Room 304, Salt Lake City, UT 84112 USA.
EM d.bedrov@utah.edu
RI li, zhe/C-9603-2014; Borodin, Oleg/B-6855-2012
OI Borodin, Oleg/0000-0002-9428-5291
FU U.S. Department of Energy [DE-AC02-05CH11231 on PO No. 6838611]; Army
Research Laboratory [W911NF-12-2-0023]
FX The authors are grateful for financial support of this work by the U.S.
Department of Energy through Grant DE-AC02-05CH11231 on PO No. 6838611
to University of Utah and by the Army Research Laboratory under
Cooperative Agreement Number W911NF-12-2-0023. The views and conclusions
contained in this document are those of the authors and should not be
interpreted as representing the official policies, either expressed or
implied, of the Army Research Laboratory or the U.S. Government.
NR 52
TC 10
Z9 10
U1 7
U2 75
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 1520-6106
J9 J PHYS CHEM B
JI J. Phys. Chem. B
PD FEB 19
PY 2015
VL 119
IS 7
BP 3085
EP 3096
DI 10.1021/jp510644k
PG 12
WC Chemistry, Physical
SC Chemistry
GA CB9HJ
UT WOS:000349942300031
PM 25592777
ER
PT J
AU Waagen, A
Verma, G
Chan, K
Swami, A
D'Souza, R
AF Waagen, Alex
Verma, Gunjan
Chan, Kevin
Swami, Ananthram
D'Souza, Raissa
TI Effect of zealotry in high-dimensional opinion dynamics models
SO PHYSICAL REVIEW E
LA English
DT Article
ID IMPACT
AB Most of the work on opinion dynamics models focuses on the case of two or three opinion types. We consider the case of an arbitrary number of opinions in the mean field case of the naming game model in which it is assumed the population is infinite and all individuals are neighbors. A particular challenge of the naming game model is that the number of variables, which corresponds to the number of possible sets of opinions, grows exponentially with the number of possible opinions. We present a method for generating mean field dynamical equations for the general case of k opinions. We calculate the steady states in two important special cases in arbitrarily high dimension: the case in which there exist zealots of only one type, and the case in which there are an equal number of zealots for each opinion. We show that in these special cases a phase transition occurs at critical values pc of the parameter p describing the fraction of zealots. In the former case, the critical value determines the threshold value beyond which it is not possible for the opinion with no zealots to be held by more nodes than the opinion with zealots, and this point remains fixed regardless of dimension. In the latter case, the critical point pc is the threshold value beyond which a stalemate between all k opinions is guaranteed, and we show that it decays precisely as a lognormal curve in k.
C1 [Waagen, Alex; D'Souza, Raissa] Univ Calif Davis, Davis, CA 95616 USA.
[Verma, Gunjan; Chan, Kevin; Swami, Ananthram] US Army Res Lab, Adelphi, MD 20783 USA.
[D'Souza, Raissa] Santa Fe Inst, Santa Fe, NM 87501 USA.
RP Waagen, A (reprint author), Univ Calif Davis, Davis, CA 95616 USA.
FU U.S. Army Research Laboratory [W911NF-09-2-0053]; U.S. Army Research
Office under MURI [W911NF-13-1-0340]
FX We gratefully acknowledge support from the U.S. Army Research Laboratory
under Cooperative Agreement No. W911NF-09-2-0053 (Network Science CTA)
and from the U.S. Army Research Office under MURI Award No.
W911NF-13-1-0340. The views and conclusions contained in this document
are those of the authors and should not be interpreted as representing
the official policies, either expressed or implied, of the Army Research
Laboratory or the U.S. Government.
NR 26
TC 12
Z9 12
U1 3
U2 14
PU AMER PHYSICAL SOC
PI COLLEGE PK
PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA
SN 1539-3755
EI 1550-2376
J9 PHYS REV E
JI Phys. Rev. E
PD FEB 18
PY 2015
VL 91
IS 2
AR 022811
DI 10.1103/PhysRevE.91.022811
PG 10
WC Physics, Fluids & Plasmas; Physics, Mathematical
SC Physics
GA CC3TV
UT WOS:000350273900008
PM 25768556
ER
PT J
AU Duy, J
Koehler, JW
Honko, AN
Minogue, TD
AF Duy, Janice
Koehler, Jeffrey W.
Honko, Anna N.
Minogue, Timothy D.
TI Optimized microRNA purification from TRIzol-treated plasma
SO BMC GENOMICS
LA English
DT Article
DE microRNA; TRIzol; Ebola virus; RNA extraction; Plasma; Biomarker;
RT-PCR; Nonhuman primate
ID CIRCULATING MICRORNAS; BLOOD; EXTRACTION; EXPRESSION; MIRNAS;
QUANTIFICATION; PCR; RNA; CHALLENGES; BIOMARKERS
AB Background: MicroRNAs (miRNAs) represent new and potentially informative diagnostic targets for disease detection and prognosis. However, little work exists documenting the effect of TRIzol, a common viral inactivation and nucleic acid extraction reagent, on miRNA purification. Here, we developed an optimized protocol for miRNA extraction from plasma samples by evaluating five different RNA extraction kits, TRIzol phase separation, purification additives, and initial plasma sample volume. This method was then used for downstream profiling of plasma miRNAs found in archived samples from one nonhuman primate (NHP) experimentally challenged with Ebola virus by the aerosol route.
Results: Comparison of real-time RT-PCR results for spiked-in and endogenous miRNA sequences determined extraction efficiencies from five different RNA purification kits. These experiments showed that 50 mu L plasma processed using the QIAGEN miRNeasy Mini Kit with 5 mu g of glycogen as a co-precipitant yielded the highest recovery of endogenous miRNAs. Using this optimized protocol, miRNAs from archived plasma samples of one rhesus macaque challenged with aerosolized Ebola virus was profiled using a targeted real-time PCR array. A total of 519 of the 752 unique miRNAs assayed were present in the plasma samples at day 0 and day 7 (time of death) post-exposure. Statistical analyses revealed 25 sequences significantly up- or down-regulated between day 0 and day 7 post infection, validating the utility of the extraction method for plasma miRNA profiling.
Conclusions: This study contributes to the knowledgebase of circulating miRNA extraction methods and expands on the potential applications of cell-free miRNA profiling for diagnostics and pathogenesis studies. Specifically, we optimized an extraction protocol for miRNAs from TRIzol-inactivated plasma samples that can be used for highly pathogenic viruses.
C1 [Duy, Janice; Koehler, Jeffrey W.; Minogue, Timothy D.] US Army, Diagnost Syst Div, Res Inst Infect Dis, Frederick, MD 21701 USA.
[Honko, Anna N.] NIAID, Integrated Res Facil, NIH, Frederick, MD 21701 USA.
[Honko, Anna N.] US Army, Virol Div, Med Inst Infect Dis, Frederick, MD 21701 USA.
RP Minogue, TD (reprint author), US Army, Diagnost Syst Div, Res Inst Infect Dis, 1425 Porter St, Frederick, MD 21701 USA.
EM timothy.d.minogue.civ@mail.mil
OI Honko, Anna/0000-0001-9165-148X; Koehler, Jeffrey/0000-0003-3225-6599
FU Defense Threat Reduction Agency (DTRA) under USAMRIID project [1442078]
FX The authors would like to thank USAMRIID Veterinary Medicine Corps for
blood samples from healthy nonhuman primates, and Dr. Samuel Dickson for
his help with statistical analyses. Research was conducted under an
IACUC approved protocol in compliance with the Animal Welfare Act, PHS
Policy, and other Federal statutes and regulations relating to animals
and experiments involving animals. The facility where this research was
conducted is accredited by the Association for Assessment and
Accreditation of Laboratory Animal Care, International and adheres to
principles stated in the Guide for the Care and Use of Laboratory
Animals, National Research Council, 2011. This research was funded by
the Defense Threat Reduction Agency (DTRA) under USAMRIID project number
1442078. The opinions, interpretations, conclusions, and recommendations
contained herein are those of the authors and are not necessarily
endorsed by the U.S. Army.
NR 44
TC 4
Z9 4
U1 4
U2 16
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1471-2164
J9 BMC GENOMICS
JI BMC Genomics
PD FEB 18
PY 2015
VL 16
AR 95
DI 10.1186/s12864-015-1299-5
PG 9
WC Biotechnology & Applied Microbiology; Genetics & Heredity
SC Biotechnology & Applied Microbiology; Genetics & Heredity
GA CC2GP
UT WOS:000350163500002
PM 25765146
ER
PT J
AU Tannenbaum, LV
Oosterbroek, LN
Caro-Riano, H
AF Tannenbaum, Lawrence V.
Oosterbroek, Leila N.
Caro-Riano, Harling
TI Compromised Chemical Toxicity in Year-Weathered Soils: Implications for
Compromised Toxicity Factors
SO HUMAN AND ECOLOGICAL RISK ASSESSMENT
LA English
DT Article
DE 2, 4-dinitrotoluene; risk; toxicity; soil; toxicity factor; lead;
weathering
ID BIOAVAILABILITY; SEQUESTRATION; DDT; PHENANTHRENE; DIELDRIN; RISK; RDX;
HMX
AB With contaminated terrestrial sites always being multiple decades old before they first submit to health risk assessments for humans and ecological receptors, there is great opportunity for soils to elicit markedly lesser chemical toxicity than would be expected. Soil aging and weathering foster various physico-chemical processes that reduce the toxic potency or bioavailability of sequestered chemicals. Because only brand new and unadulterated chemicals with seemingly maximum potencies are used in animal dosing that supports toxicity factor derivation, measured chemical concentrations in soil can be misleading, producing exaggerated risk and hazard outcomes. We sought to determine the extent to which toxicity reduction occurs in experimentally amended soils, working with large soil volumes exposed to the unimpeded ambient condition for a calendar year. A broad toxicity testing matrix for two chemicals (i.e., multiple test species, endpoints, effect level concentrations, and soil types), found species' responses in contaminated soils to be indistinguishable from those in control soil 80% and 98% of the time for the inorganic and organic compounds used, respectively; a case in point was lead with a soil concentration of 11,000mg/kg. The results suggest that incorporating a toxicity reduction term is an indispensable task when deriving toxicity factors.
C1 [Tannenbaum, Lawrence V.] Publ Hlth Command, Army Inst Publ Hlth, Aberdeen Proving Ground, MD USA.
[Oosterbroek, Leila N.; Caro-Riano, Harling] HydroQual Labs Ltd, Calgary, AB, Canada.
RP Tannenbaum, LV (reprint author), US Army Publ Hlth Command, MCHB IP REH, Bldg 1675, Apg Ea, MD 21010 USA.
EM lawrence.v.tannenbaum.civ@mail.mil
FU U.S. Army Environmental Command
FX The authors thank the U.S. Army Environmental Command (Mr. Jim Daniel)
for funding this study.
NR 24
TC 0
Z9 0
U1 1
U2 2
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1080-7039
EI 1549-7860
J9 HUM ECOL RISK ASSESS
JI Hum. Ecol. Risk Assess.
PD FEB 17
PY 2015
VL 21
IS 2
BP 375
EP 396
DI 10.1080/10807039.2014.916550
PG 22
WC Biodiversity Conservation; Environmental Sciences
SC Biodiversity & Conservation; Environmental Sciences & Ecology
GA AQ1DF
UT WOS:000342520900006
ER
PT J
AU Lee, BG
Dupuis, N
Pepeljugoski, P
Schares, L
Budd, R
Bickford, JR
Schow, CL
AF Lee, Benjamin G.
Dupuis, Nicolas
Pepeljugoski, Petar
Schares, Laurent
Budd, Russell
Bickford, Justin R.
Schow, Clint L.
TI Silicon Photonic Switch Fabrics in Computer Communications Systems
SO JOURNAL OF LIGHTWAVE TECHNOLOGY
LA English
DT Article
DE Multiprocessor interconnection networks; optical switch; silicon
photonics
ID NETWORKS-ON-CHIP; SEMICONDUCTOR OPTICAL AMPLIFIERS; ELECTROOPTIC SWITCH;
ULTRA-COMPACT; OUTPUT-POWER; INTERCONNECTION; INTEGRATION; ROUTER;
LASER; TRANSMISSION
AB We discuss silicon photonic switch fabric designs that target data-intensive computing networks, reviewing recent results, and projecting future performance goals. We analyze the achievements of demonstrated hardware in terms of switching time, footprint, crosstalk, and power consumption, concluding that the most crucial metric to improve upon is net loss. We propose integrating semiconductor optical amplifiers into the switch fabric using either flip-chip or wafer-bonding technology, and investigate its potential merits alongside several challenges in implementation. Furthermore, we explore the dominant causes of crosstalk, and discuss manners for reducing it. We perform switch simulations that project a 7-dB reduction in crosstalk, when using a push-pull, rather than a single-ended phase shifter drive scheme. We also evaluate crosstalk effects on transmission performance using a full-link model that incorporates multiple crosstalk-accumulating photonic switch hops. The study demonstrates the degree to which crosstalk may degrade signal integrity after just a few occurrences. Finally, a comparison of four topologies highlights tradeoffs in physical-layer design and scheduling complexity, illustrating the scales that may be accomplished with the simplest topologies, and the device improvements required to achieve the more robust architectures.
C1 [Lee, Benjamin G.; Dupuis, Nicolas; Pepeljugoski, Petar; Schares, Laurent; Budd, Russell; Schow, Clint L.] IBM Corp, Thomas J Watson Res Ctr, Yorktown Hts, NY 10598 USA.
[Bickford, Justin R.] US Army Res Lab, Adelphi Lab Ctr, Adelphi, MD 20783 USA.
RP Lee, BG (reprint author), IBM Corp, Thomas J Watson Res Ctr, Yorktown Hts, NY 10598 USA.
EM bglee@us.ibm.com; ndupuis@us.ibm.com; petarp@us.ibm.com;
schares@us.ibm.com; rbudd@us.ibm.com; justin.r.bickford.civ@mail.mil;
cschow@us.ibm.com
FU Defense Advanced Research Projects Agency; Army Research Laboratory
[W911NF-12-2-0051]
FX This work was supported by the Defense Advanced Research Projects Agency
and the Army Research Laboratory under Contract W911NF-12-2-0051. The
views, opinions, and/or findings contained in this article are those of
the authors and should not be interpreted as representing the official
views or policies, either expressed or implied, of DARPA or the
Department of Defense. Approved for public release, distribution
unlimited.
NR 52
TC 17
Z9 17
U1 1
U2 16
PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
PI PISCATAWAY
PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA
SN 0733-8724
EI 1558-2213
J9 J LIGHTWAVE TECHNOL
JI J. Lightwave Technol.
PD FEB 15
PY 2015
VL 33
IS 4
SI SI
BP 768
EP 777
DI 10.1109/JLT.2014.2371616
PG 10
WC Engineering, Electrical & Electronic; Optics; Telecommunications
SC Engineering; Optics; Telecommunications
GA CC3BC
UT WOS:000350218100007
ER
PT J
AU Earwood, JS
Thompson, TD
AF Earwood, John Scott
Thompson, Timothy Daniel
TI Hemoptysis: Evaluation and Management
SO AMERICAN FAMILY PHYSICIAN
LA English
DT Article
ID MASSIVE HEMOPTYSIS; TUBERCULOSIS; PREDICTION; DIAGNOSIS
AB Hemoptysis is the expectoration of blood from the lung parenchyma or airways. The initial step in the evaluation is determining the origin of bleeding. Pseudohemoptysis is identified through the history and physical examination. In adults, acute respiratory tract infections (e.g., bronchitis, pneumonia), bronchiectasis, asthma, chronic obstructive pulmonary disease, and malignancy are the most common causes. Tuberculosis is a major cause of hemoptysis in endemic regions of the world. Although tuberculosis rates are low in the United States, they are increased in persons who are homeless or who were born in other countries; consideration for testing should be made on an individual basis. Hemodynamic instability, abnormal gas exchange, cardiopulmonary comorbidities, and lesions at high risk of massive bleeding warrant inpatient evaluation. Chest radiography is recommended as the initial diagnostic test for hemodynamically stable patients with hemoptysis. Further evaluation with computed tomography with or without bronchoscopy is recommended in patients with massive hemoptysis, those with abnormal radiographic findings, and those with risk factors for malignancy despite normal radiographic findings. Copyright (C) 2015 American Academy of Family Physicians.
C1 [Earwood, John Scott] Dwight D Eisenhower Army Med Ctr, Family Med Residency Program, Ft Gordon, GA 30905 USA.
[Earwood, John Scott] Dwight D Eisenhower Army Med Ctr, Family Med Residency Program, Dept Family Med, Ft Gordon, GA 30905 USA.
[Thompson, Timothy Daniel] Mendoza Clin, Ft Bliss, TX USA.
RP Earwood, JS (reprint author), Dwight D Eisenhower Army Med Ctr, 300 Hosp Dr, Ft Gordon, GA 30905 USA.
EM john.s.earwood.civ@mail.mil
NR 18
TC 3
Z9 3
U1 1
U2 7
PU AMER ACAD FAMILY PHYSICIANS
PI KANSAS CITY
PA 8880 WARD PARKWAY, KANSAS CITY, MO 64114-2797 USA
SN 0002-838X
EI 1532-0650
J9 AM FAM PHYSICIAN
JI Am. Fam. Physician
PD FEB 15
PY 2015
VL 91
IS 4
BP 243
EP 249
PG 7
WC Primary Health Care; Medicine, General & Internal
SC General & Internal Medicine
GA CC0GY
UT WOS:000350015000005
PM 25955625
ER
PT J
AU Lahiri, D
Karp, J
Keshri, AK
Zhang, C
Dulikravich, GS
Kecskes, LJ
Agarwal, A
AF Lahiri, Debrupa
Karp, Jeffrey
Keshri, Anup K.
Zhang, Cheng
Dulikravich, George S.
Kecskes, Laszlo J.
Agarwal, Arvind
TI Scratch induced deformation behavior of hafnium based bulk metallic
glass at multiple load scales
SO JOURNAL OF NON-CRYSTALLINE SOLIDS
LA English
DT Article
DE Bulk metallic glass; Hafnium; Multi-scale scratch behavior; Shear band
structure; Free volume; Strain hardening
ID MECHANICAL-BEHAVIOR; AMORPHOUS-ALLOYS; ROOM-TEMPERATURE;
WEAR-RESISTANCE; FORMING ABILITY; STRAIN-RATE; NANO-SCALE; INDENTATION;
NANOCRYSTALLIZATION; CRYSTALLIZATION
AB The scratch induced deformation behavior of Hafnium based bulk metallic glass (BMG) at micro- and macro-load scales is reported in this study. The micro-scratch deals with a normal load range of 1000-8000 mu N, whereas the macro-scale scratches are made with a normal load reaching up to 5 N. Increase in the load beyond 2000 mu N changes the deformation mechanism from plowing to fracture and chipping. The plastic strain is mostly accommodated by shear band formation with a significant amount of free volume generation. A change in the strain rate helps in the nucleation of shear bands and prevents fracture and chipping in the case of micro-scratches made at ramp loading as compared to constant load. Higher strain rate and heat generation in the track causes increased strain hardening in macro-scratch, which could be attributed to increased probability of nano-crystallization. Complex shear band structure is evolved during scratching, which is attributed to the mixed type of loading, consisting of compressive normal load and lateral shear load across scratch-track. (C) 2014 Elsevier B.V. All rights reserved.
C1 [Lahiri, Debrupa; Karp, Jeffrey; Keshri, Anup K.; Zhang, Cheng; Agarwal, Arvind] Florida Int Univ, Nanomech & Nanotribol Lab, Miami, FL 33174 USA.
[Dulikravich, George S.] Florida Int Univ, MAIDROC, Miami, FL 33174 USA.
[Kecskes, Laszlo J.] US Army, Res Lab, Aberdeen Proving Ground, MD 21005 USA.
RP Agarwal, A (reprint author), Florida Int Univ, Nanomech & Nanotribol Lab, Miami, FL 33174 USA.
EM agarwala@fiu.edu
FU US Army Research Office [W911NF-06-1-0328]
FX AA and DL acknowledge support of AMERI at FIU, in maintaining and
providing the research facilities. The authors acknowledge the help from
Prof. Todd C. Hufnagel at Johns Hopkins University for synthesizing Hf
based BMG samples. GSD and M also acknowledge the research grant
W911NF-06-1-0328 from US Army Research Office.
NR 35
TC 0
Z9 0
U1 4
U2 16
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0022-3093
EI 1873-4812
J9 J NON-CRYST SOLIDS
JI J. Non-Cryst. Solids
PD FEB 15
PY 2015
VL 410
BP 118
EP 126
DI 10.1016/j.jnoncrysol.2014.12.010
PG 9
WC Materials Science, Ceramics; Materials Science, Multidisciplinary
SC Materials Science
GA CB6HA
UT WOS:000349726900019
ER
PT J
AU Paris, DH
Chattopadhyay, S
Jiang, J
Nawtaisong, P
Lee, JS
Tan, E
Dela Cruz, E
Burgos, J
Abalos, R
Blacksell, SD
Lombardini, E
Turner, GD
Day, NPJ
Richards, AL
AF Paris, Daniel H.
Chattopadhyay, Suchismita
Jiang, Ju
Nawtaisong, Pruksa
Lee, John S.
Tan, Esterlina
Dela Cruz, Eduardo
Burgos, Jasmin
Abalos, Rodolfo
Blacksell, Stuart D.
Lombardini, Eric
Turner, Gareth D.
Day, Nicholas P. J.
Richards, Allen L.
TI A Nonhuman Primate Scrub Typhus Model: Protective Immune Responses
Induced by pKarp47 DNA Vaccination in Cynomolgus Macaques
SO JOURNAL OF IMMUNOLOGY
LA English
DT Article
ID ENCEPHALITIS-VIRUS REPLICON; SILVERED LEAF MONKEYS;
RICKETTSIA-TSUTSUGAMUSHI; ORIENTIA-TSUTSUGAMUSHI; PRESBYTIS-CRISTATUS;
MACACA-FASCICULARIS; GAMMA-INTERFERON; GUINEA-PIGS; INFECTION; VACCINES
AB We developed an intradermal (ID) challenge cynomolgus macaque (Macaca fascicularis) model of scrub typhus, the leading cause of treatable undifferentiated febrile illness in tropical Asia, caused by the obligate intracellular bacterium, Orientia tsutsugamushi. A well-characterized animal model is required for the development of clinically relevant diagnostic assays and evaluation of therapeutic agents and candidate vaccines. We investigated scrub typhus disease pathophysiology and evaluated two O. tsutsugamushi 47-kDa, Ag-based candidate vaccines, a DNA plasmid vaccine (pKarp47), and a virus-vectored vaccine (Kp47/47-Venezuelan equine encephalitis virus replicon particle) for safety, immunogenicity, and efficacy against homologous ID challenge with O. tsutsugamushi Karp. Control cynomolgus macaques developed fever, classic eschars, lymphadenopathy, bacteremia, altered liver function, increased WBC counts, pathogen-specific Ab (IgM and IgG), and cell-mediated immune responses. Vaccinated macaques receiving the DNA plasmid pKarp47 vaccine had significantly increased O. tsutsugamushi-specific, IFN-gamma-producing PBMCs (p = 0.04), reduced eschar frequency and bacteremia duration (p <= 0.01), delayed bacteremia onset (p < 0.05), reduced circulating bacterial biomass (p = 0.01), and greater reduction of liver transaminase levels (p < 0.03) than controls. This study demonstrates a vaccine-induced immune response capable of conferring sterile immunity against high-dose homologous ID challenge of O. tsutsugamushi in a nonhuman primate model, and it provides insight into cell-mediated immune control of O. tsutsugamushi and dissemination dynamics, highlights the importance of bacteremia indices for evaluation of both natural and vaccine-induced immune responses, and importantly, to our knowledge, has determined the first phenotypic correlates of immune protection in scrub typhus. We conclude that this model is suitable for detailed investigations into vaccine-induced immune responses and correlates of immunity for scrub typhus.
C1 [Paris, Daniel H.; Nawtaisong, Pruksa; Blacksell, Stuart D.; Turner, Gareth D.; Day, Nicholas P. J.] Mahidol Univ, Fac Trop Med, Mahidol Oxford Trop Med Res Unit, Bangkok 10400, Thailand.
[Paris, Daniel H.; Blacksell, Stuart D.; Turner, Gareth D.; Day, Nicholas P. J.] Univ Oxford, Nuffield Dept Clin Med, Ctr Trop Med & Global Hlth, Oxford OX3 7FZ, England.
[Chattopadhyay, Suchismita; Jiang, Ju; Richards, Allen L.] Naval Med Res Ctr, Viral & Rickettsial Dis Dept, Silver Spring, MD 20910 USA.
[Lee, John S.] Walter Reed Army Inst Res, Div Entomol, Silver Spring, MD 20910 USA.
[Tan, Esterlina; Dela Cruz, Eduardo; Burgos, Jasmin; Abalos, Rodolfo] Leonard Wood Mem Inst, Cebu 6000, Philippines.
[Lombardini, Eric] Armed Forces Med Res Inst Sci, Dept Vet Med, Bangkok 10400, Thailand.
[Richards, Allen L.] Uniformed Serv Univ Hlth Sci, Dept Prevent Med & Biometr, Bethesda, MD 20814 USA.
RP Paris, DH (reprint author), Mahidol Univ, Fac Trop Med, Mahidol Oxford Trop Med Res Unit, 3rd Floor,60th Anniversary Chalermprakiat Bldg, Bangkok 10400, Thailand.
EM parigi@tropmedres.ac
OI Blacksell, Stuart/0000-0001-6576-726X; PARIS, Daniel/0000-0003-4743-5987
FU Department of Defense, Military Infectious Diseases Research Program
Work Unit [6000.RAD1.J.A0310]; Wellcome Trust of Great Britain
[089275/Z/09/Z]; Wellcome Trust Clinical Research Training Fellowship
[078990/Z/06/Z]
FX This work was supported by the Department of Defense, Military
Infectious Diseases Research Program Work Unit 6000.RAD1.J.A0310, the
Wellcome Trust of Great Britain (Grant 089275/Z/09/Z), and a Wellcome
Trust Clinical Research Training Fellowship (Grant 078990/Z/06/Z to
D.H.P.).
NR 65
TC 6
Z9 6
U1 0
U2 5
PU AMER ASSOC IMMUNOLOGISTS
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0022-1767
EI 1550-6606
J9 J IMMUNOL
JI J. Immunol.
PD FEB 15
PY 2015
VL 194
IS 4
BP 1702
EP 1716
DI 10.4049/jimmunol.1402244
PG 15
WC Immunology
SC Immunology
GA CB2MP
UT WOS:000349462000034
PM 25601925
ER
PT J
AU Middlemas, S
Fang, ZZ
Fan, P
AF Middlemas, Scott
Fang, Z. Zak
Fan, Peng
TI Life cycle assessment comparison of emerging and traditional Titanium
dioxide manufacturing processes
SO JOURNAL OF CLEANER PRODUCTION
LA English
DT Article
DE Titanium dioxide; Energy analysis; LCA; Chloride process; Sulfate
process; Altairnano process
ID SODIUM-HYDROXIDE; SLAG; DECOMPOSITION; PIGMENT; ILMENITE; CELLS; METAL
AB Titanium dioxide (TiO2) is used as pigment in a wide variety of domestic and industrial applications, and is becoming an increasingly valuable nanomaterial. TiO2 is manufactured by the traditional sulfate process or high temperature chloride process. Several hydrometallurgical processes for manufacturing TiO2 have recently emerged to reduce the environmental impact of TiO2 production. A new process is reported that features alkaline roasting of titania slag (ARTS), with subsequent washing, leaching, solvent extraction, hydrolysis, and calcination stages, and implements the recycling and regeneration of alkaline and acid process streams to minimize waste generation. A virtual ARTS processing plant is described in detail and is used to conduct an LCA comparison with the sulfate, chloride, and Altairnano processes. The cumulative energy demand (CED) and total CO2 emissions for the ARTS process are 92.6 MJ/kg TiO2 and 7.47 kg CO2/kg TiO2, respectively, which compares favorably with the traditional and Altairnano processes. (C) 2014 Elsevier Ltd. All rights reserved.
C1 [Middlemas, Scott; Fang, Z. Zak; Fan, Peng] Univ Utah, Dept Met Engn, Salt Lake City, UT 84112 USA.
[Middlemas, Scott] US Army Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA.
RP Middlemas, S (reprint author), US Army Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA.
EM scott.middlemas.ctr@mail.mil
OI Middlemas, Scott/0000-0003-0133-7126
FU US Department of Energy; Office of Energy Efficiency and Renewable
Energy [DE-EE003476]; U.S. Army Research Laboratory (ARL)
FX The US Department of Energy and the Office of Energy Efficiency and
Renewable Energy is acknowledged for funding this research
(DE-EE003476). The authors also thank Rio Tinto Iron and Titanium for
providing raw materials for the experimental portion of this study. The
authors would also like to acknowledge Mike Lefler, Matt Ludwig,
Prashant Bagri, Brent Randall, and Randy Crossman for their assistance
in the development of the process flow sheet. S.M. would like to
acknowledge support from the U.S. Army Research Laboratory (ARL)
administered by the Oak Ridge Institute for Science and Education
through an interagency agreement between the U.S. Department of Energy
and ARL.
NR 50
TC 5
Z9 6
U1 5
U2 45
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0959-6526
EI 1879-1786
J9 J CLEAN PROD
JI J. Clean Prod.
PD FEB 15
PY 2015
VL 89
BP 137
EP 147
DI 10.1016/j.jclepro.2014.11.019
PG 11
WC GREEN & SUSTAINABLE SCIENCE & TECHNOLOGY; Engineering, Environmental;
Environmental Sciences
SC Science & Technology - Other Topics; Engineering; Environmental Sciences
& Ecology
GA CA5TH
UT WOS:000348970200014
ER
PT J
AU Kalambate, PK
Dar, RA
Karna, SP
Srivastava, AK
AF Kalambate, Pramod K.
Dar, Riyaz A.
Karna, Shashi P.
Srivastava, Ashwini K.
TI High performance supercapacitor based on graphene-silver
nanoparticles-polypyrrole nanocomposite coated on glassy carbon
electrode
SO JOURNAL OF POWER SOURCES
LA English
DT Article
DE Graphene; Silver nanoparticles; Polypyrrole; Supercapacitor; Energy
density
ID CONDUCTING-POLYMER; ELECTROCHEMICAL SUPERCAPACITORS; OXIDE/POLYPYRROLE
COMPOSITE; ENERGY-STORAGE; POLYANILINE; NANOTUBES; DENSITY; OXIDE;
FABRICATION; CAPACITANCE
AB In the current study, we present a new hybrid material of double layer capacitive material graphene (GNS), pseudo capacitive polypyrrole (PPY) and highly conducting silver nanoparticles (AgNPs). Graphene/Silver nanoparticles/polypyrrole (GNS/AgNPs/PPY) composite has been synthesized by in situ oxidative polymerization of pyrrole in the presence of GNS and AgNPs. The different mass concentrations of AgNPs were utilized to improve the capacitive performance of supercapacitor. Characterization of the electrode material has been carried out by X-ray diffraction, Raman spectroscopy, Thermal methods, Scanning electron microscopy (SEM) and Transmission electron microscopy. SEM images showed that PPY nanoparticles uniformly coated on graphene sheets along with AgNPs. Electrochemical characterization of the electrode surface has been carried out by means of cyclic voltammetry, galvanostatic charge/discharge and electrochemical impedance spectroscopy. Remarkably, GNS/AgNPs/PPY exhibits specific capacitance of 450 F g(-1) at current density of 0.9 mA g(-1), which is far better than GNS/PPY (288 F g(-1)), AgNPs/PPY (216 F g(-1)) and PPY (153 F g(-1)). Furthermore, GNS/AgNPs/PPY shows high charge discharge reversibility and retaining over 92.0% of its initial value after 1000 cycles. The cyclic stability of the composite is improved due to the synergistic effect of GNS, AgNPs and PPY. (C) 2014 Elsevier B.V. All rights reserved.
C1 [Kalambate, Pramod K.; Dar, Riyaz A.; Srivastava, Ashwini K.] Univ Mumbai, Dept Chem, Bombay 400098, Maharashtra, India.
[Karna, Shashi P.] US Army, Res Lab, Weap & Mat Res Directorate, ATTN RDRL WM, Aberdeen Proving Ground, MD 21005 USA.
RP Srivastava, AK (reprint author), Univ Mumbai, Dept Chem, Bombay 400098, Maharashtra, India.
EM aksrivastava@chem.mu.ac.in
OI Dar, Riyaz/0000-0002-4494-0702
FU US Army International Technology Center, Pacific Asia Countries, Tokyo,
Japan [FA2386-12-1-4086]
FX This research was funded by the US Army International Technology Center,
Pacific Asia Countries, Tokyo, Japan through contract number
FA2386-12-1-4086.
NR 48
TC 28
Z9 28
U1 24
U2 227
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-7753
EI 1873-2755
J9 J POWER SOURCES
JI J. Power Sources
PD FEB 15
PY 2015
VL 276
BP 262
EP 270
DI 10.1016/j.jpowsour.2014.11.130
PG 9
WC Chemistry, Physical; Electrochemistry; Energy & Fuels; Materials
Science, Multidisciplinary
SC Chemistry; Electrochemistry; Energy & Fuels; Materials Science
GA CA2OJ
UT WOS:000348747200035
ER
PT J
AU Clayton, JD
Knap, J
AF Clayton, J. D.
Knap, J.
TI Phase field modeling of directional fracture in anisotropic polycrystals
SO COMPUTATIONAL MATERIALS SCIENCE
LA English
DT Article
DE Phase field; Fracture; Polycrystal; Anisotropy; Energy minimization
ID BRITTLE-FRACTURE; NUMERICAL EXPERIMENTS; HCP METALS; GRAIN-SIZE;
DEFORMATION; SOLIDS; ZINC; FRAGMENTATION; SIMULATION; PLASTICITY
AB A phase field theory for modeling deformation and fracture of single crystals, polycrystals, and grain boundaries is developed. Anisotropies of elastic coefficients and fracture surface energy are addressed, the latter enabling favorable cleavage on intrinsically weak planes in crystals. An order parameter increases in value as damage accumulates in an element of material. The shear elastic coefficients deteriorate with cumulative damage regardless of local strain state, while the effective bulk modulus degrades only under tensile volumetric deformation. Governing equations and boundary conditions are derived using variational methods. An incremental energy minimization approach is used to predict equilibrium crack morphologies in finite element simulations of deforming polycrystals. Thin layers of material, representative of glassy second phases near grain boundaries, are assigned possibly different properties than surrounding crystals. Results of simulations of polycrystals subjected to tensile loading are reported, with base properties representative of silicon carbide or zinc. Key findings include (i) a tendency for intergranular over transgranular fracture as the grain boundary surface energy is reduced or as cleavage anisotropy is increased and (ii) an increase in overall ductility and strength, the latter similar to Hall-Petch scaling, as the absolute size of the polycrystal is reduced while holding the ratio of phase field regularization length to grain size fixed. Published by Elsevier B.V.
C1 [Clayton, J. D.] US Army, Impact Phys RDRL WMP C, Res Lab, Aberdeen Proving Ground, MD 21005 USA.
[Knap, J.] US Army, Computat Sci RDRL CIH C, Res Lab, Aberdeen Proving Ground, MD 21005 USA.
RP Clayton, JD (reprint author), US Army, Impact Phys RDRL WMP C, Res Lab, Aberdeen Proving Ground, MD 21005 USA.
EM john.d.clayton1.civ@mail.mil; jaroslaw.knap.civ@mail.mil
RI Clayton, John/C-7760-2009
NR 57
TC 7
Z9 7
U1 7
U2 46
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0927-0256
EI 1879-0801
J9 COMP MATER SCI
JI Comput. Mater. Sci.
PD FEB 15
PY 2015
VL 98
BP 158
EP 169
DI 10.1016/j.commatsci.2014.11.009
PG 12
WC Materials Science, Multidisciplinary
SC Materials Science
GA AX1WC
UT WOS:000346733000025
ER
PT J
AU Rivas, M
Vyas, V
Carter, A
Veronick, J
Khan, Y
Kolosov, OV
Polcawich, RG
Huey, BD
AF Rivas, Manuel
Vyas, Varun
Carter, Aliya
Veronick, James
Khan, Yusuf
Kolosov, Oleg V.
Polcawich, Ronald G.
Huey, Bryan D.
TI Nanoscale mapping of in situ actuating microelectromechanical systems
with AFM
SO JOURNAL OF MATERIALS RESEARCH
LA English
DT Article
ID QUARTZ TUNING FORK; ADAPTIVE OPTICS; MEMS TECHNOLOGY; DYNAMIC-BEHAVIOR;
SHEAR-FORCE; THIN-FILMS; SENSOR; MICROSCOPY; DEVICES; MICROFLUIDICS
AB Microelectromechanical systems (MEMS) are increasingly at our fingertips. To understand and thereby improve their performance, especially given their ever-decreasing sizes, it is crucial to measure their functionality in situ. Atomic force microscopy (AFM) is well suited for such studies, allowing nanoscale lateral and vertical resolution of static displacements, as well as mapping of the dynamic response of these physically actuating microsystems. In this work, the vibration of a tuning fork based viscosity sensor is mapped and compared to model experiments in air, liquid, and a curing collagen gel. The switching response of a MEMS switch with nanosecond time-scale activation is also monitored - including mapping resonances of the driving microcantilever and the displacement of an overhanging contact structure in response to periodic pulsing. Such nanoscale in situ AFM investigations of MEMS can be crucial for enhancing modeling, design, and the ultimate performance of these increasingly important and sophisticated devices.
C1 [Rivas, Manuel; Vyas, Varun; Carter, Aliya; Huey, Bryan D.] Univ Connecticut, Dept Mat Sci & Engn, Storrs, CT 06269 USA.
[Veronick, James; Khan, Yusuf] Univ Connecticut, Dept Orthopaed Surg, Ctr Hlth, Farmington, CT 06030 USA.
[Kolosov, Oleg V.] Univ Lancaster, Dept Phys, Lancaster LA1 4YB, England.
[Polcawich, Ronald G.] US Army Res Lab, Micro & Nano Elect Mat & Devices Branch, Adelphi, MD 20783 USA.
RP Huey, BD (reprint author), Univ Connecticut, Dept Mat Sci & Engn, Storrs, CT 06269 USA.
EM bhuey@ims.uconn.edu
RI Kolosov, Oleg/D-3815-2013;
OI Kolosov, Oleg/0000-0003-3278-9643; Huey, Bryan/0000-0002-1441-1180
FU Northeast LSAMP Bridge to the Doctorate (BD) program, NSF [EHR 1249283];
University of Connecticut Provosts fund; EPSRC [EP/K023373/1]; Lancaster
University; DOD:PECASE
FX Support for MR is provided by the Northeast LSAMP Bridge to the
Doctorate (BD) program, NSF:EHR 1249283; for VV, JV, YK, and BDH by the
University of Connecticut Provosts fund; for OVK from Lancaster
University and EPSRC grant EP/K023373/1; and for RP from DOD:PECASE.
MEMS specimens are gratefully acknowledged from Jeffrey S. Pulskamp and
Robert M. Proie, ARL.
NR 68
TC 0
Z9 0
U1 4
U2 16
PU CAMBRIDGE UNIV PRESS
PI NEW YORK
PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA
SN 0884-2914
EI 2044-5326
J9 J MATER RES
JI J. Mater. Res.
PD FEB 14
PY 2015
VL 30
IS 3
BP 429
EP 441
DI 10.1557/jmr.2014.353
PG 13
WC Materials Science, Multidisciplinary
SC Materials Science
GA CB9TO
UT WOS:000349976100012
ER
PT J
AU Alem, F
Yao, K
Lane, D
Calvert, V
Petricoin, EE
Kramer, L
Hale, ML
Bavari, S
Panchal, RG
Hakami, RM
AF Alem, Farhang
Yao, Kuan
Lane, Douglas
Calvert, Valerie
Petricoin, Emanuel E.
Kramer, Liana
Hale, Martha L.
Bavari, Sina
Panchal, Rekha G.
Hakami, Ramin M.
TI Host response during Yersinia pestis infection of human bronchial
epithelial cells involves negative regulation of autophagy and suggests
a modulation of survival-related and cellular growth pathways
SO FRONTIERS IN MICROBIOLOGY
LA English
DT Article
DE RPMA; Yersinia pestis; host response; signaling pathways; apoptosis and
autophagy; phosphorylation changes; cell growth; proteomics
ID MURINE PERITONEAL-MACROPHAGES; SIGNAL-TRANSDUCTION PATHWAYS;
PROTEIN-KINASE-A; NF-KAPPA-B; INDUCED APOPTOSIS; C-MYC; TRANSCRIPTION
FACTOR; MORPHOLOGICAL-CHANGES; MAMMALIAN-CELLS; III SECRETION
AB Yersinia pestis (Yp) causes the re-emerging disease plague, and is classified by the CDC and NIAID as a highest priority (Category A) pathogen. Currently, there is no approved human vaccine available and advances in early diagnostics and effective therapeutics are urgently needed. A deep understanding of the mechanisms of host response to Yp infection can significantly advance these three areas. We employed the Reverse Phase Protein Microarray (RPMA) technology to reveal the dynamic states of either protein level changes or phosphorylation changes associated with kinase-driven signaling pathways during host cell response to Yp infection. RPMA allowed quantitative profiling of changes in the intracellular communication network of human lung epithelial cells at different times post infection and in response to different treatment conditions, which included infection with the virulent Yp strain CO92, infection with a derivative avirulent strain CO92 (Pgm-, Pst-), treatment with heat inactivated CO92, and treatment with LPS. Responses to a total of 111 validated antibodies were profiled, leading to discovery of 12 novel protein hits. The RPMA analysis also identified several protein hits previously reported in the context of Yp infection. Furthermore, the results validated several proteins previously reported in the context of infection with other Yersinia species or implicated for potential relevance through recombinant protein and cell transfection studies. The RPMA results point to strong modulation of survival/apoptosis and cell growth pathways during early host response and also suggest a model of negative regulation of the autophagy pathway. We find significant cytoplasmic localization of p53 and reduced LC3-I to LC3-II conversion in response to Yp infection, consistent with negative regulation of autophagy. These studies allow for a deeper understanding of the pathogenesis mechanisms and the discovery of innovative approaches for prevention, early diagnosis, and treatment of plague.
C1 [Alem, Farhang; Yao, Kuan; Kramer, Liana; Hakami, Ramin M.] George Mason Univ, Natl Ctr Biodefense & Infect Dis, Manassas, VA 20110 USA.
[Alem, Farhang; Yao, Kuan; Kramer, Liana; Hakami, Ramin M.] George Mason Univ, Sch Syst Biol, Manassas, VA 20110 USA.
[Lane, Douglas; Hale, Martha L.; Bavari, Sina; Panchal, Rekha G.] US Army Med Res Inst Infect Dis, Frederick, MD USA.
[Calvert, Valerie; Petricoin, Emanuel E.] George Mason Univ, Sch Syst Biol, Ctr Appl Prote & Mol Med, Manassas, VA USA.
RP Hakami, RM (reprint author), George Mason Univ, Natl Ctr Biodefense & Infect Dis, 10650 Pyramid Pl, Manassas, VA 20110 USA.
EM rhakami@gmu.edu
FU U.S. Army Medical Research and Materiel Command [W81XWH-11-P-0310];
George Mason University
FX This work was supported by funding awarded by the U.S. Army Medical
Research and Materiel Command (W81XWH-11-P-0310) and George Mason
University to Ramin M. Hakami.
NR 93
TC 2
Z9 2
U1 0
U2 7
PU FRONTIERS RESEARCH FOUNDATION
PI LAUSANNE
PA PO BOX 110, LAUSANNE, 1015, SWITZERLAND
SN 1664-302X
J9 FRONT MICROBIOL
JI Front. Microbiol.
PD FEB 13
PY 2015
VL 6
AR 50
DI 10.3389/fmicb.2015.00050
PG 14
WC Microbiology
SC Microbiology
GA CC3AM
UT WOS:000350216500001
PM 25762983
ER
PT J
AU Liu, RF
Yu, XP
Wallqvist, A
AF Liu, Ruifeng
Yu, Xueping
Wallqvist, Anders
TI Data-driven identification of structural alerts for mitigating the risk
of drug-induced human liver injuries
SO JOURNAL OF CHEMINFORMATICS
LA English
DT Article
DE Drug-induced liver injury; Hepatotoxicity; Structure alert;
Bioactivation; Reactive metabolite
ID STRUCTURE-TOXICITY RELATIONSHIPS; HOSPITALIZED-PATIENTS; HEPATOTOXICITY;
BIOACTIVATION; METABOLISM; PROGRESS
AB Background: The use of structural alerts to de-prioritize compounds with undesirable features as drug candidates has been gaining in popularity. Hundreds of molecular structural moieties have been proposed as structural alerts. An emerging issue is that strict application of these alerts will result in a significant reduction of the chemistry space for new drug discovery, as more than half of the oral drugs on the market match at least one of the alerts. To mitigate this issue, we propose to apply a rigorous statistical analysis to derive/validate structural alerts before use.
Method: To derive human liver toxicity structural alerts, we retrieved all small-molecule entries from LiverTox, a U.S. National Institutes of Health online resource for information on human liver injuries induced by prescription and over-the-counter drugs and dietary supplements. We classified the compounds into hepatotoxic, nonhepatotoxic, and possible hepatotoxic classes, and performed detailed statistical analyses to identify molecular structural fragments highly enriched in the hepatotoxic class beyond random distribution as structural alerts for human liver injuries.
Results: We identified 12 molecular fragments present in multiple marketed drugs that one can consider as common "drug-like" fragments, yet they are strongly associated with drug-induced human liver injuries. Thus, these fragments may be considered as robust hepatotoxicity structural alerts suitable for use in drug discovery screening programs.
Conclusions: The use of structural alerts has contributed to the identification of many compounds with potential toxicity issues in modern drug discovery. However, with a large number of structural alerts published to date without proper validation, application of these alerts may restrict the chemistry space and prevent discovery of valuable drugs. To mitigate this issue, we showed how to use statistical analyses to develop a small, robust, and broadly applicable set of structural alerts.
C1 [Liu, Ruifeng; Yu, Xueping; Wallqvist, Anders] US Army, Med Res & Mat Command, Telemed & Adv Technol Res Ctr, Software Applicat Inst,Dept Def Biotechnol High P, Ft Detrick, MD 21702 USA.
RP Liu, RF (reprint author), US Army, Med Res & Mat Command, Telemed & Adv Technol Res Ctr, Software Applicat Inst,Dept Def Biotechnol High P, 2405 Whittier Dr, Ft Detrick, MD 21702 USA.
EM rliu@bhsai.org; awallqvist@bhsai.org
OI wallqvist, anders/0000-0002-9775-7469
FU U.S. Army Medical Research and Materiel Command (Ft. Detrick, MD), U.S.
Army's Network Science Initiative; Defense Threat Reduction Agency grant
[CBCall14-CBS-05-2-0007]
FX The authors were supported by the U.S. Army Medical Research and
Materiel Command (Ft. Detrick, MD) as part of the U.S. Army's Network
Science Initiative, and by the Defense Threat Reduction Agency grant
CBCall14-CBS-05-2-0007. The opinions and assertions contained herein are
the private views of the authors and are not to be construed as official
or as reflecting the views of the U.S. Army or of the U.S. Department of
Defense. This paper has been approved for public release with unlimited
distribution.
NR 24
TC 6
Z9 6
U1 3
U2 6
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1758-2946
J9 J CHEMINFORMATICS
JI J. Cheminformatics
PD FEB 11
PY 2015
VL 7
AR 4
DI 10.1186/s13321-015-0053-y
PG 8
WC Chemistry, Multidisciplinary; Computer Science, Information Systems;
Computer Science, Interdisciplinary Applications
SC Chemistry; Computer Science
GA CC5XS
UT WOS:000350438900001
PM 25717346
ER
PT J
AU Masser, KA
Knorr, DB
Hindenlang, MD
Yu, JH
Richardson, AD
Strawhecker, KE
Beyer, FL
Lenhart, JL
AF Masser, Kevin A.
Knorr, Daniel B., Jr.
Hindenlang, Mark D.
Yu, Jian H.
Richardson, Adam D.
Strawhecker, Kenneth E.
Beyer, Frederick L.
Lenhart, Joseph L.
TI Relating structure and chain dynamics to ballistic performance in
transparent epoxy networks exhibiting nanometer scale heterogeneity
SO POLYMER
LA English
DT Article
DE Polymer networks; Nanoscale heterogeneity; Nanostructure
ID X-RAY-SCATTERING; SMALL-ANGLE SCATTERING; HIGH-STRAIN RATES;
MOLECULAR-WEIGHT; SEGMENTED POLYURETHANES; RELAXATION PROCESSES; PHASE
INVERSION; BEHAVIOR; BLENDS; MORPHOLOGY
AB The ballistic performance was examined for a series of broad glass transition temperature epoxy formulations consisting of a di-epoxy monomer crosslinked with bi-modal mixtures of both a rigid, low molecular weight diamine and a flexible, high molecular weight diamine. Interestingly, the resins did not macro-phase separate during cure, but exhibited structural and dynamic heterogeneity on a length scale of a few nanometers, as confirmed by X-ray scattering, dynamic mechanical analysis, modulus-mapped atomic force microscopy, and broadband dielectric spectroscopy. The nano-structured resins were optically transparent and demonstrated a nearly 300% increase in ballistic energy dissipation relative to the neat resins, as well as when compared to epoxy formulations composed of similar bi-modal blends that exhibited a macro-phase separated structure. The ballistic performance is found to be insensitive to sub-glass transition temperature (T-g) relaxations, but appears to be dependent on both the nano-structure and the Vogel temperature of the high T-g component. The study demonstrates a new class of transparent protective materials composed of rigid and flexible components with a fine scale heterogeneous structure. Published by Elsevier Ltd.
C1 [Masser, Kevin A.; Knorr, Daniel B., Jr.; Hindenlang, Mark D.; Yu, Jian H.; Richardson, Adam D.; Strawhecker, Kenneth E.; Beyer, Frederick L.; Lenhart, Joseph L.] US Army, Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA.
RP Lenhart, JL (reprint author), US Army, Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA.
EM Joseph.l.lenhart.civ@mail.mil
FU ORISE Postdoctoral Research Program; Army Research Laboratory
FX MDH and ADR acknowledge the ORISE Postdoctoral Research Program and the
Army Research Laboratory for funding. The authors thank Ian McAninch for
providing infrared data on the neat epoxy materials.
NR 59
TC 6
Z9 6
U1 5
U2 41
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0032-3861
EI 1873-2291
J9 POLYMER
JI Polymer
PD FEB 10
PY 2015
VL 58
BP 96
EP 106
DI 10.1016/j.polymer.2014.12.027
PG 11
WC Polymer Science
SC Polymer Science
GA CB4II
UT WOS:000349591000013
ER
PT J
AU Sirk, TW
Karim, M
Khare, KS
Lenhart, JL
Andzelm, JW
Khare, R
AF Sirk, Timothy W.
Karim, Mir
Khare, Ketan S.
Lenhart, Joseph L.
Andzelm, Jan W.
Khare, Rajesh
TI Bi-modal polymer networks: Composition-dependent trends in thermal,
volumetric and structural properties from molecular dynamics simulation
SO POLYMER
LA English
DT Article
DE Molecular dynamics; Mixed network; Glass transition
ID CROSS-LINKED EPOXY; GLASS-TRANSITION; EFFICIENT GENERATION; AM1-BCC
MODEL; FORCE-FIELD; TEMPERATURE; BEHAVIOR; LIQUIDS; RESINS
AB Thermal and volumetric properties of mixed epoxy networks were characterized with molecular dynamics simulation. Atomistically detailed models of epoxy networks of diglycidyl ether of bisphenol (DGEBA) cured with stoichiometric binary mixtures of a flexible cross-linker poly(oxypropylene) diamine (POP) and a stiff cross-linker 4,4 '-methylenebis(cyclohexylamine) (MCA), having molecular weights of 1987 and 210 g/mol respectively, were prepared. Epoxy networks formed by five different compositions of the cross-linkers ranging from pure POP to pure MCA were constructed, and a network topology analysis was carried out to verify that each network chain was connected to all other chains by a path of bonded molecules. The glass transition temperature (T-g), coefficient of volume thermal expansion (CVTE), heat capacity and thermal conductivity of these network structures were determined as a function of the network composition. The simulated values of these properties are compared with predictions from theories, empirical correlations and experiments from the literature. In general, it is observed that an increase in the mass fraction of MCA leads to an increase in the T-g and a decrease in the CVTE; furthermore, the breadth of the transition as exhibited by the change in the specific volume, CVTE, and heat capacity increases with an increase in the MCA content. The differences in the flexibility of the network components were analyzed using a number of quantitative measures. Using these results, a molecular mechanism is proposed for the observation of the network composition dependence of the breadth of the glass transition in these systems. (C) 2015 Elsevier Ltd. All rights reserved.
C1 [Sirk, Timothy W.; Lenhart, Joseph L.; Andzelm, Jan W.] US Army Res Lab, Macromol Sci & Technol Branch, Aberdeen Proving Ground, MD USA.
[Karim, Mir; Khare, Ketan S.; Khare, Rajesh] Texas Tech Univ, Dept Chem Engn, Lubbock, TX 79409 USA.
RP Sirk, TW (reprint author), TKC Global, 2100 Muir Way, Bel Air, MD 21015 USA.
EM tim.sirk@us.army.mil; rajesh.khare@ttu.edu
RI Khare, Ketan/C-6074-2012; Khare, Rajesh/J-2079-2014
OI Khare, Ketan/0000-0002-5487-5553; Khare, Rajesh/0000-0002-8859-766X
FU U.S. Army/Battelle Memorial Institute [US0010000287704]; U.S. Army
Research Laboratory [W911QX-14-C-0016]
FX The authors thank Sindee Simon for insightful discussions on the
temperature dependence of the heat capacity. The work of MK, KSK, and RK
was supported by U.S. Army/Battelle Memorial Institute contract number
US0010000287704. The research reported in this document was also
performed in connection with contract/instrument W911QX-14-C-0016 with
the U.S. Army Research Laboratory.
NR 45
TC 7
Z9 7
U1 2
U2 29
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0032-3861
EI 1873-2291
J9 POLYMER
JI Polymer
PD FEB 10
PY 2015
VL 58
BP 199
EP 208
DI 10.1016/j.polymer.2014.12.057
PG 10
WC Polymer Science
SC Polymer Science
GA CB4II
UT WOS:000349591000025
ER
PT J
AU Zhang, ZL
Sun, BW
Johnson, BE
AF Zhang, Zhonglong
Sun, Bowen
Johnson, Billy E.
TI Integration of a benthic sediment diagenesis module into the two
dimensional hydrodynamic and water quality model - CE-QUAL-W2
SO ECOLOGICAL MODELLING
LA English
DT Review
DE CE-QUAL-W2; Water quality; Sediment oxygen demand; Nutrient release;
Organic matter; Sediment diagenesis
AB Current CE-QUAL-W2 mainly simulates hydrodynamics and eutrophication processes in the water column. The benthic sediment processes and sediment-water interactions have been neglected or very much simplified using zero-order and first-order rates. In this study a benthic sediment diagenesis module was developed and integrated into CE-QUAL-W2. Enhanced CE-QUAL-W2 was capable of simulating the dynamic releases of ammonium, nitrate, phosphorus, dissolved silica and dissolved methane from the sediment to the overlying water, as well as benthic sediment oxygen demand. The oxidation of sulfides is included for salt water sediments. The ability of CE-QUAL-W2 model to correctly predict sediment-water nutrient fluxes and sediment oxygen demand was evaluated against SedFlux and CE-QUAL-ICM models through a series of case studies. These case studies were chosen for representing various sedimentation and environmental conditions. The simulated sediment-water nutrient fluxes and sediment oxygen demand over time were generally in good agreement with these two model results for all data sets. The effect of benthic sediment diffusive thickness, particle mixing coefficients on nutrient releases from sediments and sediment oxygen demand were examined. Enhanced CE-QUAL-W2 model was also applied to the Lower Minnesota River for further evaluating its performance. This paper presents the sediment diagenesis module development, validation tests and application of the enhanced CE-QUAL-W2 model. (C) 2014 Elsevier B.V. All rights reserved.
C1 [Zhang, Zhonglong] US Army, Engineer Res & Dev Ctr, Environm Lab, BTS, Vicksburg, MS 39180 USA.
[Sun, Bowen] Tianjin Univ, State Key Lab Hydraul Engn Simulat & Safety, Tianjin 300072, Peoples R China.
[Johnson, Billy E.] US Army, Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA.
RP Zhang, ZL (reprint author), US Army, Engineer Res & Dev Ctr, Environm Lab, BTS, Vicksburg, MS 39180 USA.
EM zhonglong.zhang@erdc.dren.mil
NR 15
TC 3
Z9 3
U1 4
U2 29
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0304-3800
EI 1872-7026
J9 ECOL MODEL
JI Ecol. Model.
PD FEB 10
PY 2015
VL 297
BP 213
EP 231
DI 10.1016/j.ecolmodel.2014.10.025
PG 19
WC Ecology
SC Environmental Sciences & Ecology
GA CB1ZA
UT WOS:000349425300023
ER
PT J
AU Redding, B
Hill, SC
Alexson, D
Wang, CJ
Pan, YL
AF Redding, Brandon
Hill, Steven C.
Alexson, Dimitri
Wang, Chuji
Pan, Yong-Le
TI Photophoretic trapping of airborne particles using ultraviolet
illumination
SO OPTICS EXPRESS
LA English
DT Article
ID AIR; MANIPULATION; BACTERIA; FORCES; MOTION; BEAMS; MODEL
AB We demonstrate photophoretic trapping of micron-sized absorbing particles in air using pulsed and continuous-wave (CW) ultraviolet laser illumination at wavelengths of 351 nm and 244 nm. We compared the particle trapping dynamics in two trapping geometries consisting of a hollow optical cone formed by light propagating either with or against gravity. This comparison allowed us to isolate the influence of the photophoretic force from the radiative pressure and the convective forces. We found that the absorbing spherical particles tested experienced a positive photophoretic force, whereas the spatially irregular, non-spherical particles tested experienced a negative photophoretic force. By using two trapping geometries, both spherical and non-spherical absorbing particles could be trapped and held securely in place. The position of the trapped particles exhibited a standard deviation of less than 1 mu m over 20 seconds. Moreover, by operating in the UV and deep-UV where the majority of airborne materials are absorptive, the system was able to trap a wide range of particle types. Such a general purpose optical trap could enable on-line characterization of airborne particles when coupled with interrogation techniques such as Raman spectroscopy. (C) 2015 Optical Society of America
C1 [Redding, Brandon; Hill, Steven C.; Alexson, Dimitri; Wang, Chuji; Pan, Yong-Le] US Army, Res Lab, Adelphi, MD 20783 USA.
[Wang, Chuji] Mississippi State Univ, Starkville, MS 39759 USA.
RP Pan, YL (reprint author), US Army, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA.
EM yongle.pan.civ@mail.mil
FU Defense Threat Reduction Agency (DTRA) [HDTRA136477, HDTRA1310184]; US
Army Research Laboratory mission funds; [W911NF-12-2-0019]
FX This research was supported by the Defense Threat Reduction Agency
(DTRA) under contract number HDTRA136477 and HDTRA1310184, US Army
Research Laboratory mission funds, and under Cooperative Agreement
Number W911NF-12-2-0019.
NR 30
TC 7
Z9 7
U1 4
U2 21
PU OPTICAL SOC AMER
PI WASHINGTON
PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA
SN 1094-4087
J9 OPT EXPRESS
JI Opt. Express
PD FEB 9
PY 2015
VL 23
IS 3
BP 3630
EP 3639
DI 10.1364/OE.23.003630
PG 10
WC Optics
SC Optics
GA CB5SV
UT WOS:000349688800172
PM 25836215
ER
PT J
AU Foran, CM
Baker, KM
Grosso, NR
Linkov, I
AF Foran, Christy M.
Baker, Kelsie M.
Grosso, Nancy R.
Linkov, Igor
TI An Enhanced Adaptive Management Approach for Remediation of Legacy
Mercury in the South River
SO PLOS ONE
LA English
DT Article
AB Uncertainties about future conditions and the effects of chosen actions, as well as increasing resource scarcity, have been driving forces in the utilization of adaptive management strategies. However, many applications of adaptive management have been criticized for a number of shortcomings, including a limited ability to learn from actions and a lack of consideration of stakeholder objectives. To address these criticisms, we supplement existing adaptive management approaches with a decision-analytical approach that first informs the initial selection of management alternatives and then allows for periodic re-evaluation or phased implementation of management alternatives based on monitoring information and incorporation of stakeholder values. We describe the application of this enhanced adaptive management (EAM) framework to compare remedial alternatives for mercury in the South River, based on an understanding of the loading and behavior of mercury in the South River near Waynesboro, VA. The outcomes show that the ranking of remedial alternatives is influenced by uncertainty in the mercury loading model, by the relative importance placed on different criteria, and by cost estimates. The process itself demonstrates that a decision model can link project performance criteria, decision-maker preferences, environmental models, and short- and long-term monitoring information with management choices to help shape a remediation approach that provides useful information for adaptive, incremental implementation.
C1 [Foran, Christy M.; Linkov, Igor] US Army Corps Engineers New England Dist, US States Army Engineer Res & Dev Ctr, Duty Stn, Concord, MA 01742 USA.
[Baker, Kelsie M.] US States Army Engineer Res & Dev Ctr, Concord, MA 01742 USA.
[Grosso, Nancy R.] DuPont Corp, Remediat Grp, Wilmington, DE 19805 USA.
RP Linkov, I (reprint author), US Army Corps Engineers New England Dist, US States Army Engineer Res & Dev Ctr, Duty Stn, Concord, MA 01742 USA.
EM Igor.Linkov@usace.army.mil
FU USACE through Cooperative Research and Development Agreement (CRADA);
DuPont
FX This study was funded by DuPont and USACE through Cooperative Research
and Development Agreement (CRADA). One author, Nancy Grosso, has an
affiliation to the commercial funders of this research study (DuPont).
The funders had no role in study design, data collection and analysis,
decision to publish, or preparation of the manuscript.
NR 22
TC 2
Z9 2
U1 0
U2 17
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD FEB 9
PY 2015
VL 10
IS 2
AR e0117140
DI 10.1371/journal.pone.0117140
PG 15
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA CA7UO
UT WOS:000349123100019
PM 25665032
ER
PT J
AU Ratto-Kim, S
de Souza, MS
Currier, JR
Karasavvas, N
Sidney, J
Rolland, M
Valencia-Micolta, A
Madnote, S
Sette, A
Nitayaphan, S
Pitisuttuthum, P
Kaewkungwal, J
Rerks-Ngarm, S
O'Connell, R
Michael, N
Robb, ML
Marovich, M
Kim, JH
AF Ratto-Kim, Silvia
de Souza, Mark S.
Currier, Jeffrey R.
Karasavvas, Nicos
Sidney, John
Rolland, Morgane
Valencia-Micolta, Anais
Madnote, Sirinan
Sette, Alessandro
Nitayaphan, Sorachai
Pitisuttuthum, Punnee
Kaewkungwal, Jaranit
Rerks-Ngarm, Supachai
O'Connell, Robert
Michael, Nelson
Robb, Merlin L.
Marovich, Mary
Kim, Jerome H.
TI Identification of Immunodominant CD4-Restricted Epitopes Co-Located with
Antibody Binding Sites in Individuals Vaccinated with ALVAC-HIV and
AIDSVAX B/E
SO PLOS ONE
LA English
DT Article
ID IMMUNODEFICIENCY-VIRUS TYPE-1; THAI ADULTS; SUBTYPE-B; TRIAL; V2;
IMMUNOGENICITY; EFFICACY; ENVELOPE; SAFETY; LOOP
AB We performed fine epitope mapping of the CD4+ responses in the ALVAC-HIV-AIDSVAX B/E prime-boost regimen in the Thai Phase III trial (RV144). Non-transformed Env-specific T cell lines established from RV144 vaccinees were used to determine the fine epitope mapping of the V2 and C1 responses and the HLA class II restriction. Data showed that there are two CD4+ epitopes contained within the V2 loop: one encompassing the alpha 4 beta 7 integrin binding site (AA179-181) and the other nested between two previously described genetic sieve signatures (AA169, AA181). There was no correlation between the frequencies of CD4+ fine epitope responses and binding antibody.
C1 [Ratto-Kim, Silvia; Currier, Jeffrey R.; Rolland, Morgane; Valencia-Micolta, Anais; Michael, Nelson; Robb, Merlin L.; Kim, Jerome H.] Walter Reed Army Inst Res, United States Mil HIV Res Program, Silver Spring, MD 20910 USA.
[de Souza, Mark S.; Karasavvas, Nicos; Madnote, Sirinan; O'Connell, Robert] US Army Med Component, Armed Forces Res Inst Med Sci, United States Mil HIV Res Program, Bangkok, Thailand.
[Sidney, John; Sette, Alessandro] La Jolla Inst Allergy & Immunol, La Jolla, CA 92037 USA.
[Nitayaphan, Sorachai] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand.
[Pitisuttuthum, Punnee] Mahidol Univ, Fac Trop Med, Vaccine Trials Ctr, Bangkok 10400, Thailand.
[Kaewkungwal, Jaranit] Mahidol Univ, Fac Trop Med, Ctr Excellence Biomed & Publ Hlth Informat, Bangkok 11000, Thailand.
[Rerks-Ngarm, Supachai] Minist Publ Hlth, Dept Dis Control, Nonthaburi 11000, Thailand.
[Marovich, Mary] NIH, Off AIDS Res, Bethesda, MD 20892 USA.
RP Ratto-Kim, S (reprint author), Walter Reed Army Inst Res, United States Mil HIV Res Program, Silver Spring, MD 20910 USA.
EM sratto-kim@hivresearch.org
FU Henry M. Jackson Foundation [W81XWH-07-2-0067]; U.S. Department of
Defense
FX This work was funded by the cooperative agreement (W81XWH-07-2-0067)
between the Henry M. Jackson Foundation for the Advancement of Military
Medicine and the U.S. Department of Defense. The funders had no role in
study design, data collection and analysis, decision to publish, or
preparation of the manuscript. The views expressed herein are those of
the authors and should not be construed to represent the positions of
the U.S. Army or Department of Defense.
NR 16
TC 5
Z9 5
U1 0
U2 16
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD FEB 9
PY 2015
VL 10
IS 2
AR e0115582
DI 10.1371/journal.pone.0115582
PG 9
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA CA7UO
UT WOS:000349123100004
PM 25665096
ER
PT J
AU Cao, Q
Thawait, G
Gang, GJ
Zbijewski, W
Reigel, T
Brown, T
Corner, B
Demehri, S
Siewerdsen, JH
AF Cao, Qian
Thawait, Gaurav
Gang, Grace J.
Zbijewski, Wojciech
Reigel, Thomas
Brown, Tyler
Corner, Brian
Demehri, Shadpour
Siewerdsen, Jeffrey H.
TI Characterization of 3D joint space morphology using an electrostatic
model (with application to osteoarthritis)
SO PHYSICS IN MEDICINE AND BIOLOGY
LA English
DT Article
DE joint space; computed tomography; electrostatics; arthritis; modeling;
knee; bone
ID BEAM CT SYSTEM; OPTIMIZATION; EXTREMITY
AB Joint space morphology can be indicative of the risk, presence, progression, and/or treatment response of disease or trauma. We describe a novel methodology of characterizing joint space morphology in high-resolution 3D images (e.g. cone-beam CT (CBCT)) using a model based on elementary electrostatics that overcomes a variety of basic limitations of existing 2D and 3D methods. The method models each surface of a joint as a conductor at fixed electrostatic potential and characterizes the intra-articular space in terms of the electric field lines resulting from the solution of Gauss' Law and the Laplace equation. As a test case, the method was applied to discrimination of healthy and osteoarthritic subjects (N = 39) in 3D images of the knee acquired on an extremity CBCT system. The method demonstrated improved diagnostic performance (area under the receiver operating characteristic curve, AUC > 0.98) compared to simpler methods of quantitative measurement and qualitative image-based assessment by three expert musculoskeletal radiologists (AUC = 0.87, p-value = 0.007). The method is applicable to simple (e.g. the knee or elbow) or multi-axial joints (e.g. the wrist or ankle) and may provide a useful means of quantitatively assessing a variety of joint pathologies.
C1 [Cao, Qian; Gang, Grace J.; Zbijewski, Wojciech; Reigel, Thomas; Siewerdsen, Jeffrey H.] Johns Hopkins Univ, Dept Biomed Engn, Baltimore, MD 21218 USA.
[Thawait, Gaurav; Demehri, Shadpour; Siewerdsen, Jeffrey H.] Johns Hopkins Univ, Russell H Morgan Dept Radiol, Baltimore, MD USA.
[Brown, Tyler; Corner, Brian] US Army Natick Soldier Res, Ctr Dev & Engn, Natick, MA USA.
RP Cao, Q (reprint author), Johns Hopkins Univ, Dept Biomed Engn, Baltimore, MD 21218 USA.
EM jeff.siewerdsen@jhu.edu
FU [NIH-R21-AR-062293]
FX This research was supported by NIH-R21-AR-062293 and collaboration with
the US Army Natick Soldier Research, Development, and Engineering
Center. The authors thank Dr J Yorkston and Dr N Packard (Carestream
Health) for their support on this project, Yifu Ding and Bisakha Ray
(Department of Biomedical Engineering, Johns Hopkins University) for
early investigation of the electrostatic model, and Sureerat
Reaungamornrat (Department of Computer Science, Johns Hopkins
University) for valuable discussion of image segmentation methods.
Clinical studies were performed with assistance provided by Dr John
Carrino (clinical expertise and image interpretation), Dr Mahadevappa
Mahesh (medical physics radiation and image quality tests), Ms Shannon
Comes, Ms Martha DeCarlo, Ms Paula Frank, Ms Janet McCormack, and Mr
Anthony Petruccy (Russell H Morgan Department of Radiology, Johns
Hopkins Hospital).
NR 22
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Z9 6
U1 0
U2 1
PU IOP PUBLISHING LTD
PI BRISTOL
PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND
SN 0031-9155
EI 1361-6560
J9 PHYS MED BIOL
JI Phys. Med. Biol.
PD FEB 7
PY 2015
VL 60
IS 3
BP 947
EP 960
DI 10.1088/0031-9155/60/3/947
PG 14
WC Engineering, Biomedical; Radiology, Nuclear Medicine & Medical Imaging
SC Engineering; Radiology, Nuclear Medicine & Medical Imaging
GA CB2EB
UT WOS:000349438400007
PM 25575100
ER
PT J
AU Sherwin, JS
Gaston, JR
AF Sherwin, Jason Samuel
Gaston, Jeremy Rodney
TI Experience Does Not Equal Expertise in Recognizing Infrequent Incoming
Gunfire: Neural Markers for Experience and Task Expertise at Peak
Behavioral Performance
SO PLOS ONE
LA English
DT Article
ID PERCEPTUAL DECISION-MAKING; ELECTROMAGNETIC TOMOGRAPHY LORETA; BRAIN;
FMRI; EEG; NEGATIVITY; ERP
AB For a soldier, decisions to use force can happen rapidly and sometimes lead to undesired consequences. In many of these situations, there is a rapid assessment by the shooter that recognizes a threat and responds to it with return fire. But the neural processes underlying these rapid decisions are largely unknown, especially amongst those with extensive weapons experience and expertise. In this paper, we investigate differences in weapons experts and non-experts during an incoming gunfire detection task. Specifically, we analyzed the electroencephalography (EEG) of eleven expert marksmen/soldiers and eleven non-experts while they listened to an audio scene consisting of a sequence of incoming and non-incoming gunfire events. Subjects were tasked with identifying each event as quickly as possible and committing their choice via a motor response. Contrary to our hypothesis, experts did not have significantly better behavioral performance or faster response time than novices. Rather, novices indicated trends of better behavioral performance than experts. These group differences were more dramatic in the EEG correlates of incoming gunfire detection. Using machine learning, we found condition-discriminating EEG activity among novices showing greater magnitude and covering longer periods than those found in experts. We also compared group-level source reconstruction on the maximum discriminating neural correlates and found that each group uses different neural structures to perform the task. From condition-discriminating EEG and source localization, we found that experts perceive more categorical overlap between incoming and non-incoming gunfire. Consequently, the experts did not perform as well behaviorally as the novices. We explain these unexpected group differences as a consequence of experience with gunfire not being equivalent to expertise in recognizing incoming gunfire.
C1 [Sherwin, Jason Samuel] Suny Downstate Med Ctr, Dept Ophthalmol, Brooklyn, NY 11203 USA.
[Sherwin, Jason Samuel; Gaston, Jeremy Rodney] US Army Res Lab, Human Res & Engn Directorate, Aberdeen Proving Ground, MD USA.
RP Sherwin, JS (reprint author), Suny Downstate Med Ctr, Dept Ophthalmol, Brooklyn, NY 11203 USA.
EM jason.sherwin@downstate.edu
FU U.S. Army Research Office [W911NF-11-1-0219]; U.S. Army Research
Laboratory
FX This work was supported by a grant from the U.S. Army Research Office
(W911NF-11-1-0219) and in part by an appointment to the U.S. Army
Research Laboratory Postdoctoral Fellowship Program administered by the
Oak Ridge Associated Universities through a contract with the U.S. Army
Research Laboratory.
NR 31
TC 0
Z9 0
U1 0
U2 11
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD FEB 6
PY 2015
VL 10
IS 2
AR e0115629
DI 10.1371/journal.pone.0115629
PG 24
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA CB2GK
UT WOS:000349444900026
PM 25658335
ER
PT J
AU Hammamieh, R
Chakraborty, N
Lin, YX
Shupp, JW
Miller, SA
Morris, S
Jett, M
AF Hammamieh, Rasha
Chakraborty, Nabarun
Lin, Yixin
Shupp, Jeffrey W.
Miller, Stacy-Ann
Morris, Sam
Jett, Marti
TI Characterization of the interaction of staphylococcal enterotoxin B with
CD1d expressed in human renal proximal tubule epithelial cells
SO BMC MICROBIOLOGY
LA English
DT Article
ID T-CELLS; SUPERANTIGEN GENES; IMMUNE-SYSTEM; CUTTING EDGE; TOXIC-SHOCK;
NKT CELLS; AUREUS; KIDNEY; IMMUNOASSAY; ACTIVATION
AB Background: Participation of renal cells in the pathogenesis of staphylococcal enterotoxin B (SEB) is critical for late cleansing and sequestration of the antigens facilitated by CD1d mediated antigen sensing and recognition. This is a noted deviation from the typical antigen recognition process that recruits the major histocompatibility complex class II (MHC II) molecules. The immunological importance of CD1d is underscored by its influences on the performances of natural killer T-cells and thereby mediates the innate and adaptive immune systems.
Results: Using diffraction-based dotReady (TM) immunoassays, the present study showed that SEB directly and specifically conjugated to CD1d. The specificity of the conjugation between SEB and CD1d expressed on human renal proximal tubule epithelial cells (RPTEC) was further established by selective inhibition of CD1d prior to its exposure to SEB. We found that SEB induced the expression of CD1d on the cell surface prompting a rapid conjugation between them. The mRNA transcripts encoding CD1d remained elevated potentially after completing the antigen cleansing process.
Conclusion: Molecular targets associated with the delayed pathogenic response have essential therapeutic values. Particularly in the event of bioterrorism, the caregivers are typically able to intervene much later than the toxic exposures. Given circumstances mandate a paradigm shift from the conventional therapeutic strategy that counts on targeting the host markers responding to the early assault of pathogens. We demonstrated the role of CD1d in the late stage of pathogen recognition and cleansing, and thereby underscored its clinical potential in treating bioweaponizable antigens, such as Staphylococcal enterotoxin B (SEB).
C1 [Hammamieh, Rasha; Chakraborty, Nabarun; Miller, Stacy-Ann; Jett, Marti] US Army, Ctr Environm Hlth Res Ft Detrick, Ft Detrick, MD 21702 USA.
[Lin, Yixin; Morris, Sam] Axela Inc, Toronto, ON M9W 1B3, Canada.
[Shupp, Jeffrey W.] Washington Hosp Ctr, Dept Surg, Burn Ctr, Washington, DC 20010 USA.
RP Hammamieh, R (reprint author), US Army, Ctr Environm Hlth Res Ft Detrick, 568 Doughten Dr, Ft Detrick, MD 21702 USA.
EM Rasha.Hammamieh1.civ@mail.mil
FU DTRA: Host Factors [CB3293]; Shock-Inducing Bioagents
FX Authors like to acknowledge the insightful contribution from the
internal editor Dr. Julia Scheerer. RH, NC, SM and MJ like to
acknowledge the funding from DTRA: CB3293-Host Factors and
Shock-Inducing Bioagents.
NR 60
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Z9 0
U1 0
U2 3
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1471-2180
J9 BMC MICROBIOL
JI BMC Microbiol.
PD FEB 4
PY 2015
VL 15
AR 12
DI 10.1186/s12866-015-0344-5
PG 10
WC Microbiology
SC Microbiology
GA CB0VW
UT WOS:000349346800002
PM 25649790
ER
PT J
AU Rapp, PE
Keyser, DO
Albano, A
Hernandez, R
Gibson, DB
Zambon, RA
Hairston, WD
Hughes, JD
Krystal, A
Nichols, AS
AF Rapp, Paul E.
Keyser, David O.
Albano, Alfonso
Hernandez, Rene
Gibson, Douglas B.
Zambon, Robert A.
Hairston, W. David
Hughes, John D.
Krystal, Andrew
Nichols, Andrew S.
TI Traumatic brain injury detection using electrophysiological methods
SO FRONTIERS IN HUMAN NEUROSCIENCE
LA English
DT Review
DE event-related potentials; EEG; traumatic brain injury; gEEG; non-linear
dynamical analysis
ID CLOSED-HEAD-INJURY; EVENT-RELATED POTENTIALS; GRAPH-THEORETICAL
ANALYSIS; TEST-RETEST RELIABILITY; SMALL-WORLD NETWORKS;
ATTENTION-DEFICIT/HYPERACTIVITY DISORDER; INTRACLASS
CORRELATION-COEFFICIENTS; MILD COGNITIVE IMPAIRMENT; MAJOR DEPRESSIVE
DISORDER; AUDITORY ODDBALL TASK
AB Measuring neuronal activity with electrophysiological methods may be useful in detecting neurological dysfunctions, such as mild traumatic brain injury (mTBI). This approach may be particularly valuable for rapid detection in at-risk populations including military service members and athletes. Electrophysiological methods, such as quantitative electroencephalography (gEEG) and recording event-related potentials (ERPs) may be promising; however, the field is nascent and significant controversy exists on the efficacy and accuracy of the approaches as diagnostic tools. For example, the specific measures derived from an electroencephalogram (EEG) that are most suitable as markers of dysfunction have not been clearly established. A study was conducted to summarize and evaluate the statistical rigor of evidence on the overall utility of gEEG as an mTBI detection tool. The analysis evaluated gEEG measures/parameters that may be most suitable as fieldable diagnostic tools, identified other types of EEG measures and analysis methods of promise, recommended specific measures and analysis methods for further development as mTBI detection tools, identified research gaps in the field, and recommended future research and development thrust areas. The gEEG study group formed the following conclusions: (1) Individual gEEG measures provide limited diagnostic utility for mTBI. However, many measures can be important features of gEEG discriminant functions, which do show significant promise as mTBI detection tools. (2) ERPs offer utility in mTBI detection. In fact, evidence indicates that ERPs can identify abnormalities in cases where EEGs alone are non-disclosing. (3)The standard mathematical procedures used in the characterization of mTBI EEGs should be expanded to incorporate newer methods of analysis including non-linear dynamical analysis, complexity measures, analysis of causal interactions, graph theory, and information dynamics. (4) Reports of high specificity in gEEG evaluations of TBI must be interpreted with care. High specificities have been reported in carefully constructed clinical studies in which healthy controls were compared against a carefully selected TBI population. The published literature indicates, however, that similar abnormalities in gEEG measures are observed in other neuropsychiatric disorders. While it may be possible to distinguish a clinical patient from a healthy control participant with this technology, these measures are unlikely to discriminate between, for example, major depressive disorder, bipolar disorder, or TBI. The specificities observed in these clinical studies may well be lost in real world clinical practice. (5)The absence of specificity does not preclude clinical utility. The possibility of use as a longitudinal measure of treatment response remains. However, efficacy as a longitudinal clinical measure does require acceptable test-retest reliability. To date, very few test retest reliability studies have been published with gEEG data obtained from TBI patients or from healthy controls. This is a particular concern because high variability is a known characteristic of the injured central nervous system.
C1 [Rapp, Paul E.; Keyser, David O.] Uniformed Serv Univ Hlth Sci, Sch Med, Bethesda, MD 20814 USA.
[Albano, Alfonso] Bryn Mawr Coll, Bryn Mawr, PA 19010 USA.
[Hernandez, Rene] US Navy, Bur Med & Surg, Frederick, MD USA.
[Gibson, Douglas B.] US Army, Res Inst, Ft Belvoir, VA USA.
[Zambon, Robert A.; Nichols, Andrew S.] Booz Allen Hamilton Inc, Mclean, VA USA.
[Hairston, W. David] US Army, Res Lab, Aberdeen, MD USA.
[Hughes, John D.] Naval Med Res Ctr, Silver Spring, MD USA.
[Krystal, Andrew] Duke Univ, Durham, NC USA.
RP Keyser, DO (reprint author), Uniformed Serv Univ Hlth Sci, Dept Mil & Emergency Med, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA.
EM david.keyser@usuhs.edu
OI lechner, courtlen/0000-0001-8929-6407; Hairston, W.
David/0000-0003-4432-8430
FU Combat Casualty Care Research Program (CCCRP) of the U.S. Army Medical
Research & Materiel Command (USAMRMC); Traumatic Injury Research Program
of the Uniformed Services University of the Health Sciences; Defense
Medical Research and Development Program; United States Marine Corps
Systems Command
FX The opinions and assertions contained herein are the private opinions of
the authors and are not to be construed as official or reflecting the
views of the United Sates Navy, Department of Defense nor the US
Government. This research effort was supported by the Combat Casualty
Care Research Program (CCCRP) of the U.S. Army Medical Research &
Materiel Command (USAMRMC). Paul E. Rapp and David O. Keyser would like
to acknowledge support from the Traumatic Injury Research Program of the
Uniformed Services University of the Health Sciences, from the Defense
Medical Research and Development Program and from the United States
Marine Corps Systems Command. Drs. John D. Hughes and Rene Hernandez are
military service members. This work was prepared as part of their
official duties. Title 17 U.S.C. 105 provides that "Copyright protection
under this title is not available for any work of the United States
Government." Title 17 U.S.C. 101 defines a U.S. Government work as a
work prepared by a military service member or employee of the U.S.
Government as part of that person's official duties.
NR 397
TC 8
Z9 9
U1 4
U2 29
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA PO BOX 110, EPFL INNOVATION PARK, BUILDING I, LAUSANNE, 1015,
SWITZERLAND
SN 1662-5161
J9 FRONT HUM NEUROSCI
JI Front. Hum. Neurosci.
PD FEB 4
PY 2015
VL 9
AR 11
DI 10.3389/fnhum.2015.00011
PG 32
WC Neurosciences; Psychology
SC Neurosciences & Neurology; Psychology
GA CA4ZX
UT WOS:000348917700001
PM 25698950
ER
PT J
AU Li, XY
Deng, ZQD
Brown, RS
Fu, T
Martinez, JJ
McMichael, GA
Skalski, JR
Townsend, RL
Trumbo, BA
Ahmann, ML
Renholds, JF
AF Li, Xinya
Deng, Zhiqun D.
Brown, Richard S.
Fu, Tao
Martinez, Jayson J.
McMichael, Geoffrey A.
Skalski, John R.
Townsend, Richard L.
Trumbo, Bradly A.
Ahmann, Martin L.
Renholds, Jon F.
TI Migration depth and residence time of juvenile salmonids in the forebays
of hydropower dams prior to passage through turbines or juvenile bypass
systems: implications for turbine-passage survival
SO CONSERVATION PHYSIOLOGY
LA English
DT Article
DE Acclimation depth; acoustic telemetry; juvenile salmonid; migration
depth; three-dimensional tracking; turbine passage
ID ACOUSTIC TELEMETRY SYSTEM; DIEL VERTICAL MIGRATION; HYDROTURBINE
PASSAGE; ANTIPREDATION WINDOW; SOCKEYE-SALMON; INSTRUMENTATION;
BAROTRAUMA; TRACKING; DESIGN
AB Little is known about the three-dimensional depth distributions in rivers of individually marked fish that are in close proximity to hydropower facilities. Knowledge of the depth distributions of fish approaching dams can be used to understand how vulnerable fish are to injuries such as barotrauma as they pass through dams. To predict the possibility of barotrauma injury caused by pressure changes during turbine passage, it is necessary to understand fish behaviour relative to acclimation depth in dam forebays as they approach turbines. A guiding study was conducted using high-resolution three-dimensional tracking results of salmonids implanted with Juvenile Salmon Acoustic Telemetry System transmitters to investigate the depth distributions of subyearling and yearling Chinook salmon (Oncorhynchus tshawytscha) and juvenile steelhead (Oncorhynchus mykiss) passing two dams on the Snake River in Washington State. Multiple approaches were evaluated to describe the depth at which fish were acclimated, and statistical analyses were performed on large data sets extracted from similar to 28 000 individually tagged fish during 2012 and 2013. Our study identified patterns of depth distributions of juvenile salmonids in forebays prior to passage through turbines or juvenile bypass systems. This research indicates that the median depth at which juvenile salmonids approached turbines ranged from 2.8 to 12.2 m, with the depths varying by species/life history, year, location (which dam) and diel period (between day and night). One of the most enlightening findings was the difference in dam passage associated with the diel period. The amount of time that turbine-passed fish spent in the immediate forebay prior to entering the powerhouse was much lower during the night than during the day. This research will allow scientists to understand turbine-passage survival better and enable them to assess more accurately the effects of dam passage on juvenile salmon survival.
C1 [Li, Xinya; Deng, Zhiqun D.; Fu, Tao; Martinez, Jayson J.] Pacific NW Natl Lab, Hydrol Grp, 3320 Innovat Blvd,POB 999,MSIN K9-33, Richland, WA 99352 USA.
[Brown, Richard S.; McMichael, Geoffrey A.] Pacific NW Natl Lab, Ecol Grp, Richland, WA 99352 USA.
[Skalski, John R.; Townsend, Richard L.] Univ Washington, Sch Aquat & Fishery Sci, Seattle, WA 98101 USA.
[Trumbo, Bradly A.; Ahmann, Martin L.; Renholds, Jon F.] US Army Corps Engineers, Walla Walla, WA 99362 USA.
RP Deng, ZQD (reprint author), Pacific NW Natl Lab, Hydrol Grp, 3320 Innovat Blvd,POB 999,MSIN K9-33, Richland, WA 99352 USA.
EM zhiqun.deng@pnnl.gov
RI Deng, Daniel/A-9536-2011
OI Deng, Daniel/0000-0002-8300-8766
FU US Army Corps of Engineers, Walla Walla District
FX This work was supported by the US Army Corps of Engineers, Walla Walla
District.
NR 33
TC 0
Z9 0
U1 10
U2 13
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 2051-1434
J9 CONSERV PHYSIOL
JI Conserv. Physiol.
PD FEB 3
PY 2015
VL 3
AR cou064
DI 10.1093/conphys/cou064
PG 17
WC Biodiversity Conservation; Ecology; Environmental Sciences; Physiology
SC Biodiversity & Conservation; Environmental Sciences & Ecology;
Physiology
GA DK8QV
UT WOS:000375194200001
PM 27293685
ER
PT J
AU Welkos, S
Bozue, J
Twenhafel, N
Cote, C
AF Welkos, Susan
Bozue, Joel
Twenhafel, Nancy
Cote, Christopher
TI Animal Models for the Pathogenesis, Treatment, and Prevention of
Infection by Bacillus anthracis
SO MICROBIOLOGY SPECTRUM
LA English
DT Article
ID EXPERIMENTAL INHALATION ANTHRAX; RECOMBINANT PROTECTIVE ANTIGEN; AEROSOL
CHALLENGE MODEL; EXPERIMENTAL RESPIRATORY ANTHRAX; HUMAN
MONOCLONAL-ANTIBODY; LETHAL FACTOR COMPONENTS; IIA PHOSPHOLIPASE A(2);
ZEALAND WHITE-RABBITS; AFRICAN-GREEN MONKEY; AMES STRAIN SPORES
AB This article reviews the characteristics of the major animal models utilized for studies on Bacillus anthracis and highlights their contributions to understanding the pathogenesis and host responses to anthrax and its treatment and prevention. Advantages and drawbacks associated with each model, to include the major models (murine, guinea pig, rabbit, nonhuman primate, and rat), and other less frequently utilized models, are discussed. Although the three principal forms of anthrax are addressed, the main focus of this review is on models for inhalational anthrax. The selection of an animal model for study is often not straightforward and is dependent on the specific aims of the research or test. No single animal species provides complete equivalence to humans; however, each species, when used appropriately, can contribute to a more complete understanding of anthrax and its etiologic agent.
C1 [Welkos, Susan; Bozue, Joel; Cote, Christopher] US Army Med Res Inst Infect Dis, Bacteriol Div, Frederick, MD 21702 USA.
[Twenhafel, Nancy] US Army Med Res Inst Infect Dis, Pathol Div, Frederick, MD 21702 USA.
RP Welkos, S (reprint author), US Army Med Res Inst Infect Dis, Bacteriol Div, Frederick, MD 21702 USA.
EM susan.welkos@us.army.mil
NR 389
TC 0
Z9 0
U1 2
U2 3
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
EI 2165-0497
J9 MICROBIOL SPECTR
JI Microbiol. Spectr.
PD FEB
PY 2015
VL 3
IS 1
AR TBS-0001-2012
DI 10.1128/microbiolspec.TBS-0001-2012
PG 38
WC Microbiology
SC Microbiology
GA CU2DI
UT WOS:000363332500017
PM 26104551
ER
PT J
AU Hubbard, K
Beske, P
Lyman, M
McNutt, P
AF Hubbard, Kyle
Beske, Phillip
Lyman, Megan
McNutt, Patrick
TI Functional Evaluation of Biological Neurotoxins in Networked Cultures of
Stem Cell-derived Central Nervous System Neurons
SO JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
LA English
DT Article
DE Neuroscience; Issue 96; embryonic stem cells; stem cell-derived neurons;
botulinum neurotoxin detection; electrophysiology; synapse; neuronal
networks; glutamatergic synapse; GABAergic synapse
ID BOTULINUM NEUROTOXIN; NEUROMUSCULAR-JUNCTION; IN-VIVO; DERIVATION;
IDENTIFICATION; MOUSE
AB Therapeutic and mechanistic studies of the presynaptically targeted clostridial neurotoxins (CNTs) have been limited by the need for a scalable, cell-based model that produces functioning synapses and undergoes physiological responses to intoxication. Here we describe a simple and robust method to efficiently differentiate murine embryonic stem cells (ESCs) into defined lineages of synaptically active, networked neurons. Following an 8 day differentiation protocol, mouse embryonic stem cell-derived neurons (ESNs) rapidly express and compartmentalize neurotypic proteins, form neuronal morphologies and develop intrinsic electrical responses. By 18 days after differentiation (DIV 18), ESNs exhibit active glutamatergic and gamma-aminobutyric acid (GABA)ergic synapses and emergent network behaviors characterized by an excitatory: inhibitory balance. To determine whether intoxication with CNTs functionally antagonizes synaptic neurotransmission, thereby replicating the in vivo pathophysiology that is responsible for clinical manifestations of botulism or tetanus, whole-cell patch clamp electrophysiology was used to quantify spontaneous miniature excitatory post-synaptic currents (mEPSCs) in ESNs exposed to tetanus neurotoxin (TeNT) or botulinum neurotoxin (BoNT) serotypes / A-/G. In all cases, ESNs exhibited near-complete loss of synaptic activity within 20 hr. Intoxicated neurons remained viable, as demonstrated by unchanged resting membrane potentials and intrinsic electrical responses. To further characterize the sensitivity of this approach, dose-dependent effects of intoxication on synaptic activity were measured 20 hr after addition of BoNT/A. Intoxication with 0.005 mu M BoNT/A resulted in a significant decrement in mEPSCs, with a median inhibitory concentration (IC50) of 0.013 mu M. Comparisons of median doses indicate that functional measurements of synaptic inhibition are faster, more specific and more sensitive than SNARE cleavage assays or the mouse lethality assay. These data validate the use of synaptically coupled, stem cell-derived neurons for the highly specific and sensitive detection of CNTs.
C1 [Hubbard, Kyle; Beske, Phillip; Lyman, Megan; McNutt, Patrick] US Army, Med Res Inst Chem Def, Div Res, Cellular Mol Biol Branch, Aberdeen Proving Ground, MD 21010 USA.
RP Hubbard, K (reprint author), US Army, Med Res Inst Chem Def, Div Res, Cellular Mol Biol Branch, Aberdeen Proving Ground, MD 21010 USA.
EM kyle.s.hubbard.ctr@mail.mil
OI McNutt, Patrick/0000-0002-5703-4565
FU National Institutes of Health National Institute of Allergy and
Infectious Diseases [AOD12058-0001-0000]; Defense Threat Reduction
Agency - Joint Science and Technology Office, Medical ST Division
[CBM.THRTOX.01.10.RC.023, CBM.THRTOX.01.RC.014]
FX This work was funded by the National Institutes of Health National
Institute of Allergy and Infectious Diseases (IAA number
AOD12058-0001-0000) and the Defense Threat Reduction Agency - Joint
Science and Technology Office, Medical S&T Division (grant numbers
CBM.THRTOX.01.10.RC.023 and CBM.THRTOX.01.RC.014). This research was
performed while P.B. held a Defense Threat Reduction Agency-National
Research Council Research Associateship Award and K.H. held a National
Research Council Research Associateship Award. We thank Angela Adkins
and Kaylie Tuznik (USAMRICD) for technical assistance; and Cindy Kronman
(USAMRICD) for editorial assistance. The views expressed in this article
are those of the authors and do not reflect the official policy of the
Department of Army, Department of Defense, or the U.S. Government.
NR 20
TC 0
Z9 0
U1 0
U2 1
PU JOURNAL OF VISUALIZED EXPERIMENTS
PI CAMBRIDGE
PA 1 ALEWIFE CENTER, STE 200, CAMBRIDGE, MA 02140 USA
SN 1940-087X
J9 JOVE-J VIS EXP
JI J. Vis. Exp.
PD FEB
PY 2015
IS 96
AR e52361
DI 10.3791/52361
PG 10
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA CR7MH
UT WOS:000361533700028
ER
PT J
AU Muniz, A
Ramesh, KR
Greene, WA
Choi, JH
Wang, HC
AF Muniz, Alberto
Ramesh, Kaini R.
Greene, Whitney A.
Choi, Jae-Hyek
Wang, Heuy-Ching
TI Deriving Retinal Pigment Epithelium (RPE) from Induced Pluripotent Stem
(iPS) Cells by Different Sizes of Embryoid Bodies
SO JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
LA English
DT Article
DE Stem Cell Biology; Issue 96; Induced pluripotent stem (iPS) cells;
retinal pigment epithelium (RPE); retinal pigment epithelium derived
from induced pluripotent stem (iPS-RPE) cells; tissue engineering;
embryoid bodies (EBs)
ID HUMAN BLASTOCYSTS; IN-VITRO; LINES
AB Pluripotent stem cells possess the ability to proliferate indefinitely and to differentiate into almost any cell type. Additionally, the development of techniques to reprogram somatic cells into induced pluripotent stem (iPS) cells has generated interest and excitement towards the possibility of customized personal regenerative medicine. However, the efficiency of stem cell differentiation towards a desired lineage remains low. The purpose of this study is to describe a protocol to derive retinal pigment epithelium (RPE) from iPS cells (iPS-RPE) by applying a tissue engineering approach to generate homogenous populations of embryoid bodies (EBs), a common intermediate during in vitro differentiation. The protocol applies the formation of specific size of EBs using microwell plate technology. The methods for identifying protein and gene markers of RPE by immunocytochemistry and reverse-transcription polymerase chain reaction (RT-PCR) are also explained. Finally, the efficiency of differentiation in different sizes of EBs monitored by fluorescence-activated cell sorting (FACS) analysis of RPE markers is described. These techniques will facilitate the differentiation of iPS cells into RPE for future applications.
C1 [Muniz, Alberto; Ramesh, Kaini R.; Greene, Whitney A.; Choi, Jae-Hyek; Wang, Heuy-Ching] US Army Inst Surg Res, Ocular Trauma, Ft Sam Houston, TX 78234 USA.
RP Wang, HC (reprint author), US Army Inst Surg Res, Ocular Trauma, Ft Sam Houston, TX 78234 USA.
EM heuy-ching.h.wang.civ@mail.mil
FU U.S. Army Clinical Rehabilitative Medicine Research Program (CRMRP);
Military Operational Medicine Research Program (MOMRP)
FX The opinions or assertions contained herein are the private views of the
authors and are not to be construed as official or as reflecting the
views of the Department of the Army or the Department of Defense. This
research was performed while the authors Alberto Muniz, Ramesh R Kaini,
Whitney A Greene and Jae-Hyek Choi held a National Research Council
Postdoctoral Research Associateship at the USAISR. This work was
supported by U.S. Army Clinical Rehabilitative Medicine Research Program
(CRMRP) and Military Operational Medicine Research Program (MOMRP).
NR 23
TC 0
Z9 0
U1 0
U2 1
PU JOURNAL OF VISUALIZED EXPERIMENTS
PI CAMBRIDGE
PA 1 ALEWIFE CENTER, STE 200, CAMBRIDGE, MA 02140 USA
SN 1940-087X
J9 JOVE-J VIS EXP
JI J. Vis. Exp.
PD FEB
PY 2015
IS 96
AR e52262
DI 10.3791/52262
PG 10
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA CR7MH
UT WOS:000361533700018
ER
PT J
AU Wu, JC
Rose, LF
Christy, RJ
Leung, KP
Chan, RK
AF Wu, Jesse C.
Rose, Lloyd F.
Christy, Robert J.
Leung, Kai P.
Chan, Rodney K.
TI Full-Thickness Thermal Injury Delays Wound Closure in a Murine Model
SO ADVANCES IN WOUND CARE
LA English
DT Article
ID CIRCULATING ANGIOGENIC CELLS; GROWTH-FACTOR; ISCHEMIA-REPERFUSION;
DIABETIC MOUSE; MICE; FIBROBLASTS; BURNS; CONTRACTION; MOBILIZATION;
SCAFFOLDS
AB Objective: The contemporary treatment of a full-thickness burn consists of early eschar excision followed by immediate closure of the open wound using autologous skin. However, most animal models study burn wound healing with the persistence of the burn eschar. Our goal is to characterize a murine model of burn eschar excision to study wound closure kinetics.
Approach: C57BL/6 male mice were divided into three groups: contact burn, scald burn, or unburned control. Mice were burned at 80 degrees C for 5, 10, or 20 s. After 2 days, the eschar was excised and wound closure was documented until postexcision day 13. Biopsies were examined for structural morphology and a-smooth muscle actin. In a subsequent interval-excision experiment (80 degrees C scald for 10 s), the burn eschar was excised after 5 or 10 days postburn to determine the effect of a prolonged inflammatory focus.
Results: Histology of both contact and scald burns revealed characteristics of a full-thickness injury marked by collagen coagulation and tissue necrosis. Excision at 2 days after a 20-s burn from either scald or contact showed significant delay in wound closure. Interval excision of the eschar, 5 or 10 days postburn, also showed significant delay in wound closure. Both interval-excision groups showed prolonged inflammation and increased myofibroblasts.
Innovation and Conclusions: We have described the kinetics of wound closure in a murine model of a full-thickness burn excision. Both contact and scald full-thickness burn resulted in significantly delayed wound closure. In addition, prolonged interval-excision of the eschar appeared to increase and prolong inflammation.
C1 [Wu, Jesse C.; Rose, Lloyd F.; Leung, Kai P.; Chan, Rodney K.] US Army Inst Surg Res, Dent & Trauma Res Detachment, Ft Sam Houston, TX USA.
[Wu, Jesse C.; Rose, Lloyd F.; Christy, Robert J.; Leung, Kai P.; Chan, Rodney K.] US Army Inst Surg Res, Ft Sam Houston, TX USA.
RP Wu, JC (reprint author), US Army Inst Surg Res, Dent & Trauma Res Detachment, 3650 Chambers Pass, Jbsa Ft Sam Houston, TX 78234 USA.
EM jesse.c.wu.ctr@mail.mil
NR 35
TC 2
Z9 2
U1 0
U2 1
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 2162-1918
EI 2162-1934
J9 ADV WOUND CARE
JI Adv. Wound Care
PD FEB
PY 2015
VL 4
IS 2
BP 83
EP 91
DI 10.1089/wound.2014.0570
PG 9
WC Dermatology
SC Dermatology
GA CL8XP
UT WOS:000357257800002
ER
PT J
AU Plackett, TP
Lynn, DC
Zagol, BR
Malone, BA
Detro, JF
Seery, JM
Deveaux, PG
Sawyer, EM
Ellison, RW
AF Plackett, Timothy P.
Lynn, David C.
Zagol, Bradley R.
Malone, Bryan A.
Detro, John F.
Seery, Jason M.
Deveaux, Peter G.
Sawyer, Elizabeth M.
Ellison, Richard W.
TI Isolated Perivesicular Hematoma After Military Parachuting
SO AEROSPACE MEDICINE AND HUMAN PERFORMANCE
LA English
DT Article
DE military; occupational health; parachuting; hematoma; injury; urinary
bladder
ID URBAN COWBOY SYNDROME; INJURIES
AB BACKGROUND: Isolated perivesicular hematomas are uncommonly described and not an injury typically reported in the literature after parachuting or skydiving.
CASE REPORT: Herein, we described a series of three patients with isolated perivesicular hematomas sustained after military parachuting. All three patients were managed nonoperatively after a somewhat prolonged hospital course. Despite the lack of orthopedic injuries, all required physical therapy consultation and required an assisting device to aide with ambulation at the time of discharge. For all three individuals, follow-up imaging months after the injury demonstrated a continued presence of the hematoma. Clinically, the patients continued to have ambulatory and urological difficulties for several months after their injury.
DISCUSSION: This injury pattern is uncommonly reported in the literature. An appropriate index of suspicion must be maintained or there may be a delay in diagnosis. Management of these injuries requires coordinated care between the trauma service, urology, and physical therapy.
C1 Womack Army Med Ctr, Forward Surg Team 240, Ft Bragg, NC USA.
Univ Louisville, Louisville, KY 40292 USA.
RP Plackett, TP (reprint author), Loyola Univ, Med Ctr, Dept Surg, 2160 S First Ave, Maywood, IL 60153 USA.
EM tplacke78@gmail.com
NR 15
TC 0
Z9 0
U1 1
U2 1
PU AEROSPACE MEDICAL ASSOC
PI ALEXANDRIA
PA 320 S HENRY ST, ALEXANDRIA, VA 22314-3579 USA
SN 2375-6314
EI 2375-6322
J9 AEROSP MED HUM PERF
JI Aerosp. Med.Hum. Perform.
PD FEB
PY 2015
VL 86
IS 2
BP 136
EP 139
DI 10.3357/AMHP.4146.2015
PG 4
WC Biophysics; Public, Environmental & Occupational Health; Medicine,
Research & Experimental
SC Biophysics; Public, Environmental & Occupational Health; Research &
Experimental Medicine
GA CM0AG
UT WOS:000357340000011
PM 25946739
ER
PT J
AU Sund, CJ
Liu, SC
Germane, KL
Servinsky, MD
Gerlach, ES
Hurley, MM
AF Sund, Christian J.
Liu, Sanchao
Germane, Katherine L.
Servinsky, Matthew D.
Gerlach, Elliot S.
Hurley, Margaret M.
TI Phosphoketolase flux in Clostridium acetobutylicum during growth on
L-arabinose
SO MICROBIOLOGY-SGM
LA English
DT Article
ID GENOME-SCALE MODEL; METABOLIC NETWORK; TRANSCRIPTIONAL REGULATION;
ALCOHOL FERMENTATION; ELECTRON FLOW; IN-SILICO; PATHWAY; CULTURE;
SYSTEMS; SOLVENTOGENESIS
AB Clostridium acetobutylicum's metabolic pathways have been studied for decades due to its metabolic diversity and industrial value, yet many details of its metabolism continue to emerge. The flux through the recently discovered pentose phosphoketolase pathway (PKP) in C. acetobutylicum has been determined for growth on xylose but transcriptional analysis indicated the pathway may have a greater contribution to arabinose metabolism. To elucidate the role of xylulose-5-phosphate/fructose-6-phosphate phosphoketolase (XFP), and the PKP in C. acetobutylicum, experimental and computational metabolic isotope analyses were performed under growth conditions of glucose or varying concentrations of xylose and arabinose. A positional bias in labelling between carbons 2 and 4 of butyrate was found and posited to be due to an enzyme isotope effect of the thiolase enzyme. A correction for the positional bias was applied, which resulted in reduction of residual error. Comparisons between model solutions with low residual error indicated flux through each of the two XFP reactions was variable, while the combined flux of the reactions remained relatively constant. PKP utilization increased with increasing xylose concentration and this trend was further pronounced during growth on arabinose. Mutation of the gene encoding XFP almost completely abolished flux through the PKP during growth on arabinose and resulted in decreased acetate/butyrate ratios. Greater flux through the PKP during growth on arabinose when compared with xylose indicated the pathway's primary role in C. acetobutylicum is arabinose metabolism.
C1 [Sund, Christian J.; Servinsky, Matthew D.] US Army Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA.
[Liu, Sanchao; Gerlach, Elliot S.] Fed Staffing Resources, Annapolis, MD 21401 USA.
[Germane, Katherine L.] Oak Ridge Associated Univ, Belcamp, MD 21017 USA.
[Hurley, Margaret M.] US Army Res Lab, RDRL WML B, Aberdeen Proving Ground, MD 21005 USA.
RP Hurley, MM (reprint author), US Army Res Lab, RDRL WML B, 4600 Deer Creek Loop, Aberdeen Proving Ground, MD 21005 USA.
EM margaret.m.hurley.civ@mail.mil
NR 44
TC 2
Z9 2
U1 2
U2 9
PU SOC GENERAL MICROBIOLOGY
PI READING
PA MARLBOROUGH HOUSE, BASINGSTOKE RD, SPENCERS WOODS, READING RG7 1AG,
BERKS, ENGLAND
SN 1350-0872
J9 MICROBIOL-SGM
JI Microbiology-(UK)
PD FEB
PY 2015
VL 161
BP 430
EP 440
DI 10.1099/mic.0.00008
PN 2
PG 11
WC Microbiology
SC Microbiology
GA CL0QR
UT WOS:000356647800019
PM 25481877
ER
PT J
AU Kang, BH
Racicot, K
Pilkenton, SJ
Kwon, YI
Apostolidis, E
AF Kang, Bou-Hee
Racicot, Kenneth
Pilkenton, Sarah J.
Kwon, Young-In
Apostolidis, Emmanouil
TI Blueberry extract inhibits carbohydrate-hydrolyzing enzymes and these
inhibitory activities are not proanthocyanidin dependent
SO JOURNAL OF THE KOREAN SOCIETY FOR APPLIED BIOLOGICAL CHEMISTRY
LA English
DT Article
DE Alpha-glucosidase inhibition; Blueberry; Maltase inhibition;
Proanthocyanidins; Sucrase inhibition
ID ANTIOXIDANT CAPACITY; CANCER CELLS; IN-VITRO; QUANTIFICATION;
HYPERTENSION; MANAGEMENT; PATHWAY; GROWTH; RED
AB This study investigates the carbohydrate-hydrolyzing inhibitory potential of blueberry extract on carbohydrate-hydrolyzing enzymes and evaluates if the inhibitory activity is proanthocyanidin (PAC) or lower molecular weight phenolic dependent. Freeze-dried blueberry powder was extracted using acetone and subjected to C-18 extraction (BAE). Low-molecular weight phenolics (BAE-LMW) and PACs (BAE-PAC) were separated from BAE with gel filtration chromatography using LH-20 column. Total phenolic content, PAC content, and phenolic profiles using HPLC, as well as rat a-glucosidase, sucrase, and maltase inhibitory activities, were determined for all samples. The rat alpha-glucosidase inhibitory activity of BAE (IC50 0.390 mg/mL TP basis) was enhanced in BAELMW (IC50 0.242 mg/mL TP basis) and reduced in BAEPAC (IC50 0.915 mg/mL TP basis). Similar trends were observed with maltase and sucrase inhibitory activities. Our findings suggest that blueberry acetone extract has inhibitory activity on carbohydrate-hydrolyzing enzymes and this effect is dependent on LMWs rather than PAC.
C1 [Kang, Bou-Hee; Pilkenton, Sarah J.; Apostolidis, Emmanouil] Framingham State Univ, Dept Chem & Food Sci, Framingham, MA 01702 USA.
[Racicot, Kenneth] US Army, Natick Soldier Res Engn Ctr, Natick, MA 01760 USA.
[Kwon, Young-In] Hannam Univ, Dept Food & Nutr, Taejon, South Korea.
RP Apostolidis, E (reprint author), Framingham State Univ, Dept Chem & Food Sci, Framingham, MA 01702 USA.
EM bouheekang@gmail.com; kenneth.racicot.civ@mail.mil;
spilkenton@framingham.edu; youngk@hnu.kr; eapostolidis@framingham.edu
FU 6.2 Applied Research project area "Technologies for Nutrient/Novel
Delivery Systems'' from the NSRDEC Combat Feeding Directorate
FX This research was funded by the 6.2 Applied Research project area
"Technologies for Nutrient/Novel Delivery Systems'' from the NSRDEC
Combat Feeding Directorate.
NR 25
TC 1
Z9 1
U1 7
U2 17
PU KOREAN SOC APPLIED BIOLOGICAL CHEMISTRY
PI KANGNAM-GU
PA RM 803, KOREA SCIENCE & TECHNOLOGY CENTER, 635-4 YEOGSAM-DONG,
KANGNAM-GU, SEOUL 135-703, SOUTH KOREA
SN 1738-2203
EI 2234-344X
J9 J KOREAN SOC APPL BI
JI J. Korean Soc. Appl. Biol. Chem.
PD FEB
PY 2015
VL 58
IS 1
BP 127
EP 136
DI 10.1007/s13765-015-0001-6
PG 10
WC Food Science & Technology
SC Food Science & Technology
GA CH9KO
UT WOS:000354354700018
ER
PT J
AU Krakauer, T
AF Krakauer, Teresa
TI Sulfasalazine Attenuates Staphylococcal Enterotoxin B-Induced Immune
Responses
SO TOXINS
LA English
DT Article
ID TOXIC-SHOCK-SYNDROME; FACTOR-KAPPA-B; HUMAN T-CELLS; MONONUCLEAR-CELLS;
SUPERANTIGENS; RELEASE; CYTOKINES; TISSUE; BLOOD
AB Staphylococcal enterotoxin B (SEB) and related exotoxins are important virulence factors produced by Staphylococcus aureus as they cause human diseases such as food poisoning and toxic shock. These toxins bind directly to cells of the immune system resulting in hyperactivation of both T lymphocytes and monocytes/macrophages. The excessive release of proinflammatory cytokines from these cells mediates the toxic effects of SEB. This study examined the inhibitory activities of an anti-inflammatory drug, sulfasalazine, on SEB-stimulated human peripheral blood mononuclear cells (PBMC). Sulfasalazine dose-dependently inhibited tumor necrosis factor alpha, interleukin 1 (IL-1) beta, IL-2, IL-6, interferon gamma (IFN gamma), and various chemotactic cytokines from SEB-stimulated human PBMC. Sulfasalazine also potently blocked SEB-induced T cell proliferation and NF kappa B activation. These results suggest that sulfasalazine might be useful in mitigating the toxic effects of SEB by blocking SEB-induced host inflammatory cascade and signaling pathways.
C1 US Army, Dept Immunol, Mol Translat Sci Div, Med Res Inst Infect Dis, Frederick, MD 21702 USA.
RP Krakauer, T (reprint author), US Army, Dept Immunol, Mol Translat Sci Div, Med Res Inst Infect Dis, Frederick, MD 21702 USA.
EM Teresa.krakauer@us.army.mil
FU DTRA under USAMRIID [1321180]
FX This research was funded by DTRA under USAMRIID project number 1321180.
Opinions, interpretations, conclusions, and recommendations are those of
the author and are not necessarily endorsed by the U.S. Army.
NR 24
TC 2
Z9 2
U1 2
U2 4
PU MDPI AG
PI BASEL
PA POSTFACH, CH-4005 BASEL, SWITZERLAND
SN 2072-6651
J9 TOXINS
JI Toxins
PD FEB
PY 2015
VL 7
IS 2
BP 553
EP 559
DI 10.3390/toxins7020553
PG 7
WC Toxicology
SC Toxicology
GA CH3YP
UT WOS:000353967500020
PM 25688664
ER
PT J
AU Fadel, TR
Steevens, JA
Thomas, TA
Linkov, I
AF Fadel, Tarek R.
Steevens, Jeffery A.
Thomas, Treye A.
Linkov, Igor
TI The challenges of nanotechnology risk management
SO NANO TODAY
LA English
DT Article
DE Risk management; Risk assessment; Decision analysis; Policy;
Nanomaterials; Regulations
AB Recent developments in the design of advanced materials have furthered interest in the commercialization of new technologies. Central to this rapid technology revolution is the consideration of the potential environmental, health, and safety (EHS) risks associated with nanomaterials. Risk assessment has been proposed as a primary method to evaluate EHS risk and decision making, where risk assessment practitioners seek to understand what can go wrong, its likelihood of occurrence, and the ultimate consequences if it should arise. Here, we outlined recent efforts geared toward risk assessment for nanotechnologies and nanomaterials, and discuss the challenges associated with providing accurate risk information to policymakers and regulators. Risk assessment that includes analytical approaches will provide decision makers with adaptive guidance regarding how to balance risks with technological benefits and costs, communicate those trade-offs, and change nanomaterial design toward sustainable nanotechnology. Published by Elsevier Ltd.
C1 [Fadel, Tarek R.] ITRI Inc, Linthicum, MD USA.
[Steevens, Jeffery A.; Linkov, Igor] US Army, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA.
[Thomas, Treye A.] Consumer Prod Safety Commiss, Bethesda, MD USA.
RP Linkov, I (reprint author), US Army, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA.
EM Igor.Linkov@usace.army.mil
OI Fadel, Tarek/0000-0002-8416-5157
NR 13
TC 8
Z9 9
U1 2
U2 22
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1748-0132
EI 1878-044X
J9 NANO TODAY
JI Nano Today
PD FEB
PY 2015
VL 10
IS 1
BP 6
EP 10
DI 10.1016/j.nantod.2014.09.008
PG 5
WC Chemistry, Multidisciplinary; Nanoscience & Nanotechnology; Materials
Science, Multidisciplinary
SC Chemistry; Science & Technology - Other Topics; Materials Science
GA CH2PK
UT WOS:000353866900005
ER
PT J
AU Kraemer, WJ
Gordon, SE
Fragala, MS
Bush, JA
Szivak, TK
Flanagan, SD
Hooper, DR
Looney, DP
Triplett, NT
DuPont, WH
Dziados, JE
Marchitelli, LJ
Patton, JF
AF Kraemer, William J.
Gordon, Scott E.
Fragala, Maren S.
Bush, Jill A.
Szivak, Tunde K.
Flanagan, Shawn D.
Hooper, David R.
Looney, David P.
Triplett, N. Travis
DuPont, Wiliam H.
Dziados, Joseph E.
Marchitelli, Louis J.
Patton, John F.
TI The effects of exercise training programs on plasma concentrations of
proenkephalin Peptide F and catecholamines
SO PEPTIDES
LA English
DT Article
DE Proenkephalins; Opioid peptides; Epinephrine; Norepinephrine; Resistance
training; Endurance training
ID ADRENAL-MEDULLA; OPIOID PEPTIDE; ENKEPHALIN; RESPONSES; CELLS; RELEASE;
SECRETION; STORAGE; BLOOD
AB To determine if exercise training alters the pattern and magnitude of plasma concentrations of proenkephalin Peptide F and epinephrine, plasma proenkephalin [107-140] Peptide F-ir and cate-cholamines were examined pre-training (T-1), and after 4-(T-2), 8-(T-3), and 12-weeks (T-4) of training. 26 healthy men were matched and randomly assigned to one of three groups: heavy resistance strength training (Strength, n = 9), high intensity endurance training (Endurance, n = 8), or both training modalities combined (Combined, n = 9). Blood was collected using a syringe with a cannula inserted into a superficial arm vein with samples collected at rest, after each 7 min stage and 5 and 15 min into recovery. With training, all groups observed shifted plasma Peptide F responses to graded exercise, where significant increases were observed at lower exercise intensities. Increases in plasma epinephrine with exercise were observed in all groups. The Combined group saw increases at 25% at T-3 and for 50% at T-2, T-3, and T-4 which was higher than T-1. The Endurance group demonstrated increases for 50% at T-1, T-2, T-3 but not at T-4. The plasma epinephrine response to graded exercise was reduced in the Strength group. Increases in plasma norepinephrine above rest were observed starting at 50%. The Strength group demonstrated a significant reduction in norepinephrine observed at 100% at T-3 and T-4. Peptide F and catecholamines responses to graded exercise can be altered by different types of physical exercise training. Simultaneous high intensity training may produce adrenal medulla exhaustion when compared to single mode training. (C) 2015 Elsevier Inc. All rights reserved.
C1 [Kraemer, William J.; Szivak, Tunde K.; Flanagan, Shawn D.; Hooper, David R.; DuPont, Wiliam H.] Ohio State Univ, Dept Human Sci, Columbus, OH 43210 USA.
[Gordon, Scott E.] Univ N Carolina, Dept Kinesiol, Charlotte, NC 28223 USA.
[Dziados, Joseph E.; Marchitelli, Louis J.; Patton, John F.] US Army, Environm Med Res Inst, Exercise Physiol Div, Natick, MA 01760 USA.
[Bush, Jill A.] Coll New Jersey, Dept Hlth & Exercise Sci, Ewing, NJ 08618 USA.
[Fragala, Maren S.] Quest Diagnost, Sports & Human Performance Diagnost, Athlete Hlth & Performance, Madison, NJ 07940 USA.
[Looney, David P.] Univ Connecticut, Dept Kinesiol, Storrs, CT 06269 USA.
[Triplett, N. Travis] Appalachian State Univ, Dept Hlth & Exercise Sci, Boone, NC 28608 USA.
RP Kraemer, WJ (reprint author), Ohio State Univ, Dept Human Sci, A054 PAES Bldg,305W 17th Ave, Columbus, OH 43210 USA.
EM kraemer.44@osu.edu
FU Department of Defense
FX The authors thank a dedicate group of subjects show made this project
possible and colleagues at USARIEM who contributed to this project's
completion. This project was funded by internal laboratory funds from
the Department of Defense to the Exercise Physiology Division. Also, to
Dr James Vogel for his vision and support and who propelled the
accomplishments of the Division as then Director of the Exercise
Physiology Division at the USARIEM. The views, opinions, and/or findings
contained in this report are those of the author(s) and should not be
construed as an official Department of the U.S. Army position, policy,
or decision, unless so designated by other official documentation.
NR 33
TC 5
Z9 5
U1 0
U2 3
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0196-9781
EI 1873-5169
J9 PEPTIDES
JI Peptides
PD FEB
PY 2015
VL 64
BP 74
EP 81
DI 10.1016/j.peptides.2015.01.001
PG 8
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism;
Pharmacology & Pharmacy
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism;
Pharmacology & Pharmacy
GA CF8KM
UT WOS:000352808100012
PM 25582563
ER
PT J
AU Michener, LA
Kardouni, JR
Sousa, CO
Ely, JM
AF Michener, Lori A.
Kardouni, Joseph R.
Sousa, Catarina O.
Ely, Jacqueline M.
TI Validation of a sham comparator for thoracic spinal manipulation in
patients with shoulder pain
SO MANUAL THERAPY
LA English
DT Article
DE Sham; Rotator cuff; Thoracic spinal manipulation; Validity
ID ROTATOR CUFF TENDINOPATHY; IMPINGEMENT SYNDROME; MUSCULOSKELETAL PAIN;
RATING-SCALE; THERAPY; PHYSIOTHERAPY; RELIABILITY; MECHANISMS; TRIAL
AB The evidence to guide use of spinal manipulative therapy (SMT) for patients with shoulder pain is limited. A validated sham comparator is needed to ascertain the unique effects of SMT. We investigated the plausibility of a thoracic sham-SMT comparator for SMT in patients with shoulder pain. Participants (n = 56) with subacromial impingement syndrome were randomized to thoracic SMT or a sham-SMT. An examiner blinded to group assignment took measures pre- and post-treatment of shoulder active range of motion (AROM) and perceived effects of the assigned intervention. Treatment consisted of six upper, middle and lower thoracic SMT or sham-SMT. The sham-SMT was identical to the SMT, except no thrust was applied. Believability as an active treatment was measured post-treatment. Believability as an active treatment was not different between groups (chi(2) = 2.19; p = 0.15). Perceptions of effects were not different between groups at pre-treatment (t = 0.12; p = 0.90) or post-treatment (t = 0.40; p = 0.69), and demonstrated equivalency with 95% confidence between groups at pre- and post-treatment. There was no significant change in shoulder flexion in either group over time, or in the sham-SMT for internal rotation (p > 0.05). The SMT group had an increase of 6.49 degrees in internal rotation over time (p = 0.04). The thoracic sham-SMT of this study is a plausible comparator for SMT in patients with shoulder pain. The sham-SMT was believable as an active treatment, perceived as having equal beneficial effects both when verbally described and after familiarization with the treatment, and has an inert effect on shoulder AROM. This comparator can be considered for used in clinical trials investigating thoracic SMT. (C) 2014 Elsevier Ltd. All rights reserved.
C1 [Michener, Lori A.] Univ So Calif, Div Biokinesiol & Phys Therapy, Los Angeles, CA 90089 USA.
[Kardouni, Joseph R.] US Army, Environm Med Res Inst, Natick, MA 01760 USA.
[Sousa, Catarina O.] Univ Fed Rio Grande do Norte, Fac Ciencias Saude Trairi, Santa Cruz, RN, Brazil.
[Ely, Jacqueline M.] Riverside Hlth Syst, Newport News, VA 23607 USA.
RP Michener, LA (reprint author), Univ So Calif, Div Biokinesiol & Phys Therapy, 1540 E Alcazar St,CHP 155, Los Angeles, CA 90089 USA.
EM lmichene@usc.edu
FU NCATS NIH HHS [UL1 TR000058]
NR 30
TC 5
Z9 5
U1 0
U2 0
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 1356-689X
EI 1532-2769
J9 MANUAL THER
JI Man. Ther.
PD FEB
PY 2015
VL 20
IS 1
BP 171
EP 175
DI 10.1016/j.math.2014.08.008
PG 5
WC Rehabilitation
SC Rehabilitation
GA CF7WV
UT WOS:000352768000027
PM 25261090
ER
PT J
AU Daddis, GA
AF Daddis, Gregory A.
TI When Soldiers Fall: How Americans Have Confronted Combat Losses from
World War I to Afghanistan
SO AMERICAN HISTORICAL REVIEW
LA English
DT Book Review
C1 [Daddis, Gregory A.] US Mil Acad, West Point, NY 10996 USA.
RP Daddis, GA (reprint author), US Mil Acad, West Point, NY 10996 USA.
NR 1
TC 0
Z9 0
U1 0
U2 0
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0002-8762
EI 1937-5239
J9 AM HIST REV
JI Am. Hist. Rev.
PD FEB
PY 2015
VL 120
IS 1
BP 276
EP 277
PG 3
WC History
SC History
GA CE8GM
UT WOS:000352079900108
ER
PT J
AU Smith, TJ
Wilson, MA
Young, AJ
Montain, SJ
AF Smith, Tracey J.
Wilson, Marques A.
Young, Andrew J.
Montain, Scott J.
TI A suction blister model reliably assesses skin barrier restoration and
immune response
SO JOURNAL OF IMMUNOLOGICAL METHODS
LA English
DT Article
DE Suction blister; Immune function; Inflammation
ID PROINFLAMMATORY CYTOKINE PRODUCTION; RESPIRATORY-INFECTIONS; STRESS
AB Skin wound healing models can be used to detect changes in immune function in response to interventions. This study used a test-retest format to assess the reliability of a skin suction blister procedure for quantitatively evaluating human immune function in repeated measures type studies. Up to eight suction blisters (similar to 30 mm(2)) were induced via suction on each participant's left and right forearm (randomized order; blister session 1 and 2), separated by approximately one week. Fluid was sampled from each blister, and the top layer of each blister was removed to reveal up to eight skin wounds. Fluid from each wound was collected 4, 7 and 24 h after blisters were induced, and proinflammatory cytokines were measured. Transepidermal water loss (TEWL), to assess skin barrier recovery, was measured daily at each wound site until values were within 90% of baseline values (i.e., unbroken skin). Sleep, stress and inflammation (i.e., factors that affect wound healing and immune function), preceding the blister induction, were assessed via activity monitors (Actical, Philips Respironics, Murrysville, Pennsylvania), the Perceived Stress Scale (PSS) and C-reactive protein (CRP), respectively. Area-under-the-curve and TEWL, between blister session 1 and 2, were compared using Pearson correlations and partial correlations (controlling for average nightly sleep, PSS scores and CRP). The suction blister method was considered reliable for assessing immune response and skin barrier recovery if correlation coefficients reached 0.7. Volunteers (n = 16; 12 M; 4 F) were 23 +/- 5 years [mean +/- SD]. Time to skin 'larder restoration was 4.9 +/- 0.8 and 4.8 +/- 0.9 days for sessions 1 and 2, respectively. Correlation coefficients for skin barrier restoration, IL-6, IL-8 and MIP-1 alpha were 0.9 (P < 0.0001), 0.7 (P = 0.008) and 0.9 (P < 0.0001), respectively. When average nightly sleep, PSS scores and CRP (i.e., percent difference between sessions 1 and 2) were taken into consideration, correlations in immune response between sessions 1 and 2 were improved for IL-8 (0.8, P = 0.002) and TNF-alpha (0.7, P = 0.02). The skin suction blister method is sufficiently reliable for assessing skin barrier restoration and immune responsiveness. This data can be used to determine sample sizes for cross-sectional or repeated-measures types of studies testing the impact of various stressors on immune response, and/or the efficacy of interventions to mitigate decrements in immune response to stress. Published by Elsevier B.V.
C1 [Smith, Tracey J.; Wilson, Marques A.; Young, Andrew J.; Montain, Scott J.] US Army, Environm Med Res Inst, Mil Nutr Div, Natick, MA 01760 USA.
RP Smith, TJ (reprint author), US Army, Environm Med Res Inst, 15 Kansas St,Bldg 42, Natick, MA 01760 USA.
NR 15
TC 2
Z9 2
U1 1
U2 3
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0022-1759
EI 1872-7905
J9 J IMMUNOL METHODS
JI J. Immunol. Methods
PD FEB
PY 2015
VL 417
BP 124
EP 130
DI 10.1016/j.jim.2015.01.002
PG 7
WC Biochemical Research Methods; Immunology
SC Biochemistry & Molecular Biology; Immunology
GA CE7UE
UT WOS:000352046500014
PM 25585263
ER
PT J
AU Young, DA
Novy, BB
Zeller, GG
Hale, R
Hart, TC
Truelove, EL
AF Young, Douglas A.
Novy, Brian B.
Zeller, Gregory G.
Hale, Robert
Hart, Thomas C.
Truelove, Edmond L.
CA American Dental Association On Sci
TI The American Dental Association Caries Classification System for
Clinical Practice A report of the American Dental Association Council on
Scientific Affairs
SO JOURNAL OF THE AMERICAN DENTAL ASSOCIATION
LA English
DT Article
DE Caries classification system; caries lesion classification; caries
location; caries extent; caries activity; caries management
ID RISK-ASSESSMENT; APPROXIMAL SURFACES; CARIOUS LESIONS; ORAL-HEALTH;
MANAGEMENT; RELIABILITY; INDEX; MODEL
AB Background. The caries lesion, the most commonly observed sign of dental caries disease, is the cumulative result of an imbalance in the dynamic demineralization and remineralization process that causes a net mineral loss over time. A classification system to categorize the location, site of origin, extent, and when possible, activity level of caries lesions consistently over time is necessary to determine which clinical treatments and therapeutic interventions are appropriate to control and treat these lesions.
Methods. In 2008, the American Dental Association (ADA) convened a group of experts to develop an easy-to-implement caries classification system. The ADA Council on Scientific Affairs subsequently compiled information from these discussions to create the ADA Caries Classification System (CCS) presented in this article.
Conclusions. The ADA CCS offers clinicians the capability to capture the spectrum of caries disease presentations ranging from clinically unaffected (sound) tooth structure to noncavitated initial lesions to extensively cavitated advanced lesions. The ADA CCS supports a broad range of clinical management options necessary to treat both noncavitated and cavitated caries lesions.
Practical Implications. The ADA CCS is available for implementation in clinical practice to evaluate its usability, reliability, and validity. Feedback from clinical practitioners and researchers will allow system improvement. Use of the ADA CCS will offer standardized data that can be used to improve the scientific rationale for the treatment of all stages of caries disease.
C1 [Young, Douglas A.] Univ Pacific, Dept Dent Practice, San Francisco, CA USA.
[Novy, Brian B.] Loma Linda Univ, Dept Restorat Dent, Loma Linda, CA 92350 USA.
[Zeller, Gregory G.] Univ Kentucky, Coll Dent, Oral Hlth Practice, Lexington, KY USA.
[Hale, Robert] US Army Inst Surg Res, San Antonio, TX USA.
[Hart, Thomas C.] Univ Illinois, Coll Dent, Dept Periodont, Chicago, IL USA.
[Truelove, Edmond L.] Univ Washington, Sch Dent, Dept Oral Med, Seattle, WA 98195 USA.
RP Truelove, EL (reprint author), Univ Washington, Dept Oral Med, 1959 Pacific St, Seattle, WA 98195 USA.
EM edmondt@uw.edu
NR 38
TC 11
Z9 13
U1 0
U2 4
PU AMER DENTAL ASSOC
PI CHICAGO
PA 211 E CHICAGO AVE, CHICAGO, IL 60611 USA
SN 0002-8177
EI 1943-4723
J9 J AM DENT ASSOC
JI J. Am. Dent. Assoc.
PD FEB
PY 2015
VL 146
IS 2
BP 79
EP 86
DI 10.1016/j.adaj.2014.11.018
PG 8
WC Dentistry, Oral Surgery & Medicine
SC Dentistry, Oral Surgery & Medicine
GA CE9GM
UT WOS:000352152100010
PM 25637205
ER
PT J
AU Edlefsen, PT
Rolland, M
Hertz, T
Tovanabutra, S
Gartland, AJ
Decamp, AC
Magaret, CA
Ahmed, H
Gottardo, R
Juraska, M
Mccoy, C
Larsen, BB
Sanders-Buell, E
Carrico, C
Menis, S
Bose, M
Arroyo, MA
O'Connell, RJ
Nitayaphan, S
Pitisuttithum, P
Kaewkungwal, J
Rerks-Ngarm, S
Robb, ML
Kirys, T
Georgiev, IS
Kwong, PD
Scheffler, K
Pond, SLK
Carlson, JM
Michael, NL
Schief, WR
Mullins, JI
Kim, JH
Gilbert, PB
AF Edlefsen, Paul T.
Rolland, Morgane
Hertz, Tomer
Tovanabutra, Sodsai
Gartland, Andrew J.
decamp, Allan C.
Magaret, Craig A.
Ahmed, Hasan
Gottardo, Raphael
Juraska, Michal
McCoy, Connor
Larsen, Brendan B.
Sanders-Buell, Eric
Carrico, Chris
Menis, Sergey
Bose, Meera
Arroyo, Miguel A.
O'Connell, Robert J.
Nitayaphan, Sorachai
Pitisuttithum, Punnee
Kaewkungwal, Jaranit
Rerks-Ngarm, Supachai
Robb, Merlin L.
Kirys, Tatsiana
Georgiev, Ivelin S.
Kwong, Peter D.
Scheffler, Konrad
Pond, Sergei L. Kosakovsky
Carlson, Jonathan M.
Michael, Nelson L.
Schief, William R.
Mullins, James I.
Kim, Jerome H.
Gilbert, Peter B.
CA RV144 Sequencing Team
TI Comprehensive Sieve Analysis of Breakthrough HIV-1 Sequences in the
RV144 Vaccine Efficacy Trial
SO PLOS COMPUTATIONAL BIOLOGY
LA English
DT Article
ID COMPETING RISKS; PEPTIDE BINDING; CELL RESPONSES; SUBTYPE-B; PROTEIN;
ENVELOPE; NEUTRALIZATION; EPITOPES; ESCAPE; GP120
AB The RV144 clinical trial showed the partial efficacy of a vaccine regimen with an estimated vaccine efficacy (VE) of 31% for protecting low-risk Thai volunteers against acquisition of HIV-1. The impact of vaccine-induced immune responses can be investigated through sieve analysis of HIV-1 breakthrough infections (infected vaccine and placebo recipients). A V1/V2-targeted comparison of the genomes of HIV-1 breakthrough viruses identified two V2 amino acid sites that differed between the vaccine and placebo groups. Here we extended the V1/V2 analysis to the entire HIV-1 genome using an array of methods based on individual sites, k-mers and genes/proteins. We identified 56 amino acid sites or "signatures" and 119 k-mers that differed between the vaccine and placebo groups. Of those, 19 sites and 38 k-mers were located in the regions comprising the RV144 vaccine (Env-gp120, Gag, and Pro). The nine signature sites in Env-gp120 were significantly enriched for known antibody-associated sites (p = 0.0021). In particular, site 317 in the third variable loop (V3) overlapped with a hotspot of antibody recognition, and sites 369 and 424 were linked to CD4 binding site neutralization. The identified signature sites significantly covaried with other sites across the genome (mean = 32.1) more than did non-signature sites (mean = 0.9) (p < 0.0001), suggesting functional and/or structural relevance of the signature sites. Since signature sites were not preferentially restricted to the vaccine immunogens and because most of the associations were insignificant following correction for multiple testing, we predict that few of the genetic differences are strongly linked to the RV144 vaccine-induced immune pressure. In addition to presenting results of the first complete-genome analysis of the breakthrough infections in the RV144 trial, this work describes a set of statistical methods and tools applicable to analysis of breakthrough infection genomes in general vaccine efficacy trials for diverse pathogens.
C1 [Edlefsen, Paul T.; Hertz, Tomer; Gartland, Andrew J.; decamp, Allan C.; Magaret, Craig A.; Ahmed, Hasan; Gottardo, Raphael; Juraska, Michal; McCoy, Connor; Gilbert, Peter B.] Fred Hutchinson Canc Res Ctr, Vaccine & Infect Dis Div, Seattle, WA 98104 USA.
[Rolland, Morgane; Tovanabutra, Sodsai; Sanders-Buell, Eric; Bose, Meera; Robb, Merlin L.; Michael, Nelson L.; Kim, Jerome H.] US Mil HIV Res Program, Silver Spring, MD USA.
[Hertz, Tomer] Ben Gurion Univ Negev, Fac Hlth Sci, Shraga Segal Dept Microbiol Immunol & Genet, IL-84105 Beer Sheva, Israel.
[Hertz, Tomer] Ben Gurion Univ Negev, Natl Inst Biotechnol Negev, IL-84105 Beer Sheva, Israel.
[Larsen, Brendan B.; Mullins, James I.] Univ Washington, Dept Microbiol, Seattle, WA 98195 USA.
[Carrico, Chris; Menis, Sergey; Schief, William R.] Univ Washington, Dept Biochem, Seattle, WA 98195 USA.
[Carrico, Chris; Menis, Sergey; Schief, William R.] Scripps Res Inst, IAVI Neutralizing Antibody Ctr, La Jolla, CA 92037 USA.
[Carrico, Chris; Menis, Sergey; Schief, William R.] Scripps Res Inst, Dept Immunol & Microbial Sci, La Jolla, CA 92037 USA.
[Arroyo, Miguel A.; Nitayaphan, Sorachai; Kaewkungwal, Jaranit] AFRIMS, Royal Thai Army Component, Bangkok, Thailand.
[O'Connell, Robert J.] AFRIMS, US Army Component, Bangkok, Thailand.
[Pitisuttithum, Punnee] Mahidol Univ, Fac Trop Med, Bangkok, Thailand.
[Rerks-Ngarm, Supachai] Thai Minist Publ Hlth, CDC Dept, Nonthaburi, Thailand.
[Kirys, Tatsiana; Georgiev, Ivelin S.; Kwong, Peter D.] NIAID, Vaccine Res Ctr, NIH, Bethesda, MD 20892 USA.
[Scheffler, Konrad; Pond, Sergei L. Kosakovsky] Univ Calif San Diego, Dept Med, La Jolla, CA 92093 USA.
[Carlson, Jonathan M.] Microsoft Res, eSience Res Grp, Redmond, WA USA.
[Schief, William R.] Ragon Inst MGH MIT & Harvard, Cambridge, MA 02139 USA.
RP Edlefsen, PT (reprint author), Fred Hutchinson Canc Res Ctr, Vaccine & Infect Dis Div, 1124 Columbia St, Seattle, WA 98104 USA.
EM pedlefse@fredhutch.org
RI Hertz, Tomer/S-5744-2016
OI Hertz, Tomer/0000-0002-0561-1578
FU U.S. Army Medical Research and Material Command (USAMRMC)
[Y1-AI-2642-12]; National Institutes of Allergy and Infectious Diseases;
Department of Veterans Affairs, Veterans Health Administration, Office
of Research and development; Henry M. Jackson Foundation for the
Advancement of Military Medicine, Inc. [W81XWH-07-2-0067]; U.S.
Department of Defense (DOD) [W81XWH-07-2-0067]; Vaccine Research Center,
NIAID/NIH; NIH [2R37AI05465-11]
FX This study was supported in part by an Interagency Agreement
Y1-AI-2642-12 between U.S. Army Medical Research and Material Command
(USAMRMC), the National Institutes of Allergy and Infectious Diseases,
and by the Department of Veterans Affairs, Veterans Health
Administration, Office of Research and development. This work was also
supported by a cooperative agreement (W81XWH-07-2-0067) between the
Henry M. Jackson Foundation for the Advancement of Military Medicine,
Inc., and the U.S. Department of Defense (DOD). Additional support was
provided by Intramural funding of the Vaccine Research Center, NIAID/NIH
and to PBG through the NIH grant 2R37AI05465-11. The content is solely
the responsibility of the authors and does not necessarily represent the
official views of the U.S. Department of Health and Human Services,
National Institute for Allergy and Infectious Diseases, the Department
of the Army, the Department of Defense, or the Department of Veterans
Affairs. The funders had no role in study design, data collection and
analysis, decision to publish, or preparation of the manuscript.
NR 57
TC 12
Z9 12
U1 1
U2 10
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1553-734X
EI 1553-7358
J9 PLOS COMPUT BIOL
JI PLoS Comput. Biol.
PD FEB
PY 2015
VL 11
IS 2
AR UNSP e1003973
DI 10.1371/journal.pcbi.1003973
PG 37
WC Biochemical Research Methods; Mathematical & Computational Biology
SC Biochemistry & Molecular Biology; Mathematical & Computational Biology
GA CE8GX
UT WOS:000352081000005
PM 25646817
ER
PT J
AU Iiames, JS
Congalton, RG
Lewis, TE
Pilant, AN
AF Iiames, John S.
Congalton, Russell G.
Lewis, Timothy E.
Pilant, Andrew N.
TI Uncertainty Analysis in the Creation of a Fine-Resolution Leaf Area
Index (LAI) Reference Map for Validation of Moderate Resolution LAI
Products
SO REMOTE SENSING
LA English
DT Article
ID PINUS-TAEDA L.; LOBLOLLY-PINE; ACCURACY ASSESSMENT; UNITED-STATES; IMAGE
CLASSIFICATION; VEGETATION INDEXES; GROWTH; STANDS; FERTILIZATION;
FORESTS
AB The validation process for a moderate resolution leaf area index (LAI) product (i.e., MODIS) involves the creation of a high spatial resolution LAI reference map (Lai-RM), which when scaled to the moderate LAI resolution (i.e., > 1 km) allows for comparison and analysis with this LAI product. This research addresses two major sources of uncertainty in the creation of the LAI-RM: (1) the uncertainty associated with the indirect in situ optical measurements of southeastern United States needle-leaf LAI and (2) the uncertainty in the process of classifying land cover (LC). Uncertainty within the loblolly pine (Pinus taeda) in situ data collection was highest for the assessment of the plant area index (PAI), L-e (27.2%), and the woody-to-total ratio, alpha, (30.6%). The needle-to-shoot ratio, lambda(E), and the element clumping index, omega(E), contributed 14.9% and 9.3%, respectively, to the uncertainty in the calculation of LAI. Combining LC differences (3.4%) with the uncertainty within the loblolly pine component resulted in doubling the LAI-RM variability (sigma = 0.50 to sigma = 0.97) at the 1 km(2) validation site located in Appomattox, Virginia, USA.
C1 [Iiames, John S.; Pilant, Andrew N.] US EPA, Res Triangle Pk, NC 27711 USA.
[Congalton, Russell G.] Univ New Hampshire, Dept Nat Resources & Environm, Durham, NH 03824 USA.
[Lewis, Timothy E.] US Army Corps Engn, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA.
RP Iiames, JS (reprint author), US EPA, 109 TW Alexander Dr MD E243-05, Res Triangle Pk, NC 27711 USA.
EM iiames.john@epa.gov; russ.congalton@unh.edu;
timothy.e.lewis@usace.army.mil; pilant.drew@epa.gov
NR 62
TC 2
Z9 2
U1 3
U2 8
PU MDPI AG
PI BASEL
PA POSTFACH, CH-4005 BASEL, SWITZERLAND
SN 2072-4292
J9 REMOTE SENS-BASEL
JI Remote Sens.
PD FEB
PY 2015
VL 7
IS 2
BP 1397
EP 1421
DI 10.3390/rs70201397
PG 25
WC Remote Sensing
SC Remote Sensing
GA CF2TQ
UT WOS:000352400900012
ER
PT J
AU Ivins, BJ
Lange, RT
Cole, WR
Kane, R
Schwab, KA
Iverson, GL
AF Ivins, Brian J.
Lange, Rael T.
Cole, Wesley R.
Kane, Robert
Schwab, Karen A.
Iverson, Grant L.
TI Using Base Rates of Low Scores to Interpret the ANAM4 TBI-MIL Battery
Following Mild Traumatic Brain Injury
SO ARCHIVES OF CLINICAL NEUROPSYCHOLOGY
LA English
DT Article
DE Mild traumatic brain injury; Cognitive testing; Military; Low scores;
Base rates
ID HEALTHY OLDER-ADULTS; NEUROPSYCHOLOGICAL TEST-PERFORMANCE; COGNITIVE
IMPAIRMENT; MEMORY SCORES; VALIDATION; DIAGNOSIS; CRITERIA; TESTS
AB Base rates of low ANAM4 TBI-MIL scores were calculated in a convenience sample of 733 healthy male active duty soldiers using available military reference values for the following cutoffs: <= 2nd percentile (2 SDs), <= 5th percentile, <10th percentile, and <16th percentile (1 SD). Rates of low scores were also calculated in 56 active duty male soldiers who sustained an mTBI an average of 23 days (SD = 36.1) prior. 22.0% of the healthy sample and 51.8% of the mTBI sample had two or more scores below 1 SD (i.e., 16th percentile). 18.8% of the healthy sample and 44.6% of the mTBI sample had one or more scores <= 5th percentile. Rates of low scores in the healthy sample were influenced by cutoffs and race/ethnicity. Importantly, some healthy soldiers obtain at least one low score on ANAM4. These base rate analyses can improve the methodology for interpreting ANAM4 performance in clinical practice and research.
C1 [Ivins, Brian J.; Schwab, Karen A.] Def & Vet Brain Injury Ctr, Headquarters, Div Res, Silver Spring, MD 20910 USA.
[Ivins, Brian J.; Lange, Rael T.; Cole, Wesley R.] GDIT, Fairfax, VA USA.
[Lange, Rael T.; Iverson, Grant L.] Walter Reed Natl Mil Med Ctr, Def & Vet Brain Injury Ctr, Bethesda, MD USA.
[Lange, Rael T.] Univ British Columbia, Vancouver, BC V5Z 1M9, Canada.
[Cole, Wesley R.] Womack Army Med Ctr, Def & Vet Brain Injury Ctr, Ft Bragg, NC USA.
[Kane, Robert] Georgetown Univ, Washington, DC USA.
[Schwab, Karen A.] ARK Solut Inc, Reston, AR USA.
[Iverson, Grant L.] Harvard Univ, Sch Med, Dept Phys Med & Rehabil,Red Sox Fdn, Spaulding Rehabil Hosp,Massachusetts Gen Hosp,Spo, Boston, MA USA.
[Iverson, Grant L.] Massachusetts Gen Hosp, Home Base Program, Boston, MA 02114 USA.
RP Ivins, BJ (reprint author), Def & Vet Brain Injury Ctr, 1335 East West Highway,Suite 6-100, Silver Spring, MD 20910 USA.
EM brian.j.ivins.ctr@mail.mil
NR 38
TC 1
Z9 1
U1 0
U2 2
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0887-6177
EI 1873-5843
J9 ARCH CLIN NEUROPSYCH
JI Arch. Clin. Neuropsychol.
PD FEB
PY 2015
VL 30
IS 1
BP 26
EP 38
DI 10.1093/arclin/acu072
PG 13
WC Psychology, Clinical; Psychology
SC Psychology
GA CE6BA
UT WOS:000351919400003
PM 25526791
ER
PT J
AU Lester, PB
Taylor, LC
Hawkins, SA
Landry, L
AF Lester, Paul B.
Taylor, Lauren C.
Hawkins, Stacy Ann
Landry, Lisa
TI Current Directions in Military Health-care Provider Resilience
SO CURRENT PSYCHIATRY REPORTS
LA English
DT Article
DE Military; Resilience; Mental health; Provider; Compassion fatigue;
Burnout; PTSD; Depression; Development; Training
ID SECONDARY TRAUMATIC STRESS; PROFESSIONALS; DEPLOYMENT; BURNOUT
AB After more than a decade of war, the US military continues to place significant emphasis on psychological health and resilience. While research and programs that focus on the broader military community's resilience continue to emerge, less is known about and until recently little focus has been placed on military medical provider resilience. In this article, we review the literature on military medical provider resilience, provide an overview of the programmatic and technological advances designed to sustain and develop military medical provider resilience, and finally offer recommendations for future research.
C1 [Lester, Paul B.; Taylor, Lauren C.; Hawkins, Stacy Ann] Army Analyt Grp, Res Facilitat Lab, Monterey, CA 93940 USA.
[Landry, Lisa] US Army Med Dept Ctr & Sch, Dept Behav Hlth Sci, Ft Sam Houston, TX USA.
RP Lester, PB (reprint author), Army Analyt Grp, Res Facilitat Lab, Monterey, CA 93940 USA.
EM paul.b.lester.mil@mail.mil; lauren.c.taylor4.ctr@mail.mil;
Stacy.a.hawkins5.ctr@mail.mil; susan.landry.civ@mail.mil
NR 23
TC 0
Z9 0
U1 2
U2 5
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1523-3812
EI 1535-1645
J9 CURR PSYCHIAT REP
JI Curr. Psychiatry Rep.
PD FEB
PY 2015
VL 17
IS 2
AR 6
DI 10.1007/s11920-014-0539-8
PG 7
WC Psychiatry
SC Psychiatry
GA CD6XC
UT WOS:000351232700006
PM 25617036
ER
PT J
AU Panero, WR
Pigott, JS
Reaman, DM
Kabbes, JE
Liu, ZX
AF Panero, Wendy R.
Pigott, Jeffrey S.
Reaman, Daniel M.
Kabbes, Jason E.
Liu, Zhenxian
TI Dry (Mg,Fe)SiO3 perovskite in the Earth's lower mantle
SO JOURNAL OF GEOPHYSICAL RESEARCH-SOLID EARTH
LA English
DT Article
DE perovskite; mantle; water; melting; viscosity
ID MAGNESIUM-SILICATE PEROVSKITE; NOMINALLY ANHYDROUS MINERALS;
TOTAL-ENERGY CALCULATIONS; WATER STORAGE CAPACITY; WAVE BASIS-SET;
TRANSITION-ZONE; HIGH-PRESSURE; HYDROUS RINGWOODITE; MGSIO3 PEROVSKITE;
SINGLE-CRYSTAL
AB Combined synthesis experiments and first-principles calculations show that MgSiO3-perovskite with minor Al or Fe does not incorporate significant OH under lower mantle conditions. Perovskite, stishovite, and residual melt were synthesized from natural Bamble enstatite samples (Mg/(Fe+Mg)=0.89 and 0.93; Al2O3<0.1wt % with 35 and 2065ppm weight H2O, respectively) in the laser-heated diamond anvil cell at 1600-2000K and 25-65GPa. Combined Fourier transform infrared spectroscopy, X-ray diffraction, and ex situ transmission electron microscopy analysis demonstrates little difference in the resulting perovskite as a function of initial water content. Four distinct OH vibrational stretching bands are evident upon cooling below 100K (3576, 3378, 3274, and 3078cm(-1)), suggesting four potential bonding sites for OH in perovskite with a maximum water content of 220ppm weight H2O, and likely no more than 10ppm weight H2O. Complementary, Fe-free, first-principles calculations predict multiple potential bonding sites for hydrogen in perovskite, each with significant solution enthalpy (0.2eV/defect). We calculate that perovskite can dissolve less than 37ppm weight H2O (400ppm H/Si) at the top of the lower mantle, decreasing to 31ppm weight H2O (340ppm H/Si) at 125GPa and 3000K in the absence of a melt or fluid phase. We propose that these results resolve a long-standing debate of the perovskite melting curve and explain the order-of-magnitude increase in viscosity from upper to lower mantle.
C1 [Panero, Wendy R.; Pigott, Jeffrey S.; Kabbes, Jason E.] Ohio State Univ, Sch Earth Sci, Columbus, OH 43210 USA.
[Reaman, Daniel M.] US Army Res Lab, RDRL WMRD, Aberdeen, MD USA.
[Liu, Zhenxian] Carnegie Inst Sci, Geophys Lab, Washington, DC USA.
RP Panero, WR (reprint author), Ohio State Univ, Sch Earth Sci, Columbus, OH 43210 USA.
EM panero.1@osu.edu
RI Panero, Wendy/C-9602-2009
FU NSF EAR [09-55647]; Ohio Supercomputer Center [PAS0238-1]; COMPRES, the
Consortium for Materials Properties Research in Earth Sciences under NSF
[EAR 06-49658]; U.S. Department of Energy, Office of Science, Office of
Basic Energy Sciences [DE-AC02-98CH10886]
FX This work was supported by NSF EAR 09-55647 to WRP. Calculations were
performed on the Ohio Supercomputer Center with award PAS0238-1. Thanks
to Lars Stixrude and Abby Kavner for useful discussions, Tao Zhou for
the loan of the Janis cryostat, and assistance from Cameron Begg, Daniel
Huber, Billy Eymold, and Henk Colijn. The use of the U2A and X17C
beamlines at the National Synchrotron Light Source beamline is supported
by COMPRES, the Consortium for Materials Properties Research in Earth
Sciences under NSF cooperative agreement EAR 06-49658 and by the U.S.
Department of Energy, Office of Science, Office of Basic Energy
Sciences, under contract DE-AC02-98CH10886.
NR 81
TC 8
Z9 9
U1 4
U2 34
PU AMER GEOPHYSICAL UNION
PI WASHINGTON
PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA
SN 2169-9313
EI 2169-9356
J9 J GEOPHYS RES-SOL EA
JI J. Geophys. Res.-Solid Earth
PD FEB
PY 2015
VL 120
IS 2
BP 894
EP 908
DI 10.1002/2014JB011397
PG 15
WC Geochemistry & Geophysics
SC Geochemistry & Geophysics
GA CE0BD
UT WOS:000351466000015
ER
PT J
AU Bocan, TM
Panchal, RG
Bavari, S
AF Bocan, Thomas M.
Panchal, Rekha G.
Bavari, Sina
TI Applications of In Vivo Imaging in the Evaluation of the Pathophysiology
of Viral and Bacterial Infections and in Development of Countermeasures
to BSL3/4 Pathogens
SO MOLECULAR IMAGING AND BIOLOGY
LA English
DT Review
DE In vivo imaging; MRI; PET; SPECT; CT; Optical; Ultrasound; BSL3/4
pathogens
ID POSITRON-EMISSION-TOMOGRAPHY; VIRUS THYMIDINE KINASE; REPORTER GENE;
BURKHOLDERIA-PSEUDOMALLEI; MYCOBACTERIUM-TUBERCULOSIS; PLAQUE
INFLAMMATION; PET; MICE; THERAPY; EXPRESSION
AB While preclinical and clinical imaging have been applied to drug discovery/development and characterization of disease pathology, few examples exist where imaging has been used to evaluate infectious agents or countermeasures to biosafety level (BSL)3/4 threat agents. Viruses engineered with reporter constructs, i.e., enzymes and receptors, which are amenable to detection by positron emission tomography (PET), single photon emission tomography (SPECT), or magnetic resonance imaging (MRI) have been used to evaluate the biodistribution of viruses containing specific therapeutic or gene transfer payloads. Bioluminescence and nuclear approaches involving engineered reporters, direct labeling of bacteria with radiotracers, or tracking bacteria through their constitutively expressed thymidine kinase have been utilized to characterize viral and bacterial pathogens post-infection. Most PET, SPECT, CT, or MRI approaches have focused on evaluating host responses to the pathogens such as inflammation, brain neurochemistry, and structural changes and on assessing the biodistribution of radiolabeled drugs. Imaging has the potential when applied preclinically to the development of countermeasures against BSL3/4 threat agents to address the following: (1) presence, biodistribution, and time course of infection in the presence or absence of drug; (2) binding of the therapeutic to the target; and (3) expression of a pharmacologic effect either related to drug mechanism, efficacy, or safety. Preclinical imaging could potentially provide real-time dynamic tools to characterize the pathogen and animal model and for developing countermeasures under the U.S. FDA Animal Rule provision with high confidence of success and clinical benefit.
C1 [Bocan, Thomas M.; Panchal, Rekha G.; Bavari, Sina] US Army, Med Res Inst Infect Dis, Mol & Translat Sci, Ft Detrick, MD 21702 USA.
[Bocan, Thomas M.] Geneva Fdn, Tacoma, WA 98402 USA.
RP Bocan, TM (reprint author), US Army, Med Res Inst Infect Dis, Mol & Translat Sci, 1425 Porter St, Ft Detrick, MD 21702 USA.
EM Thomas.m.bocan.ctr@mail.mil
FU Geneva Foundation
FX We would like to acknowledge Mr. William F. Discher for his assistance
in drawing the two figures and Dr. Jennifer Ojeda for her scientific
input into the preparation of Fig. 2. Funding was provided by The Geneva
Foundation.
NR 98
TC 1
Z9 1
U1 2
U2 7
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1536-1632
EI 1860-2002
J9 MOL IMAGING BIOL
JI Mol. Imaging. Biol.
PD FEB
PY 2015
VL 17
IS 1
BP 4
EP 17
DI 10.1007/s11307-014-0759-7
PG 14
WC Radiology, Nuclear Medicine & Medical Imaging
SC Radiology, Nuclear Medicine & Medical Imaging
GA CD4YV
UT WOS:000351093700002
PM 25008802
ER
PT J
AU Piekiel, NW
Morris, CJ
Churaman, WA
Cunningham, ME
Lunking, DM
Currano, LJ
AF Piekiel, Nicholas W.
Morris, Christopher J.
Churaman, Wayne A.
Cunningham, Michael E.
Lunking, David M.
Currano, Luke J.
TI Combustion and Material Characterization of Highly Tunable On-Chip
Energetic Porous Silicon
SO PROPELLANTS EXPLOSIVES PYROTECHNICS
LA English
DT Article
DE Porous silicon; On-chip energetic materials; Tunable combustion; Sodium
perchlorate
ID EXPLOSIVE DEVICES; MICROCHANNELS; THERMITE; FILMS
AB We present a comprehensive investigation into the tunable combustion of on-chip porous silicon energetic materials. The exothermic reaction occurs between high surface area nanoscale porous silicon and a solution-deposited sodium perchlorate oxidizer that penetrates each pore. The resulting burn rates spanned three orders of magnitude, from 5.2 to 1950ms(-1). Material properties of the porous silicon films were characterized using gas adsorption porosimetry, SEM, and profilometry, over specific surface areas between 191 and 901m(2)g(-1), and porosities between 49 and 80%. Combustion events were characterized using high speed imaging and bomb calorimetry. Results revealed that combustion depended on several material properties including surface area and porosity of the porous silicon substrate, with the peak flame speed occurring at 895m(2)g(-1) specific surface area, 3.32nm pore size, and 72% porosity. Measured heat of combustion increased with porosity over the range of 65-75%, up to 22.5kJg(-1) of porous silicon at 75% porosity. These measurements along with gravimetric determinations of oxidizer pore loading suggest that the system was typically fuel rich, with macroscopic morphology and porous silicon film mechanical integrity generally limiting the realistic range of porosity values to less than stoichiometric conditions.
C1 [Piekiel, Nicholas W.; Morris, Christopher J.; Churaman, Wayne A.; Cunningham, Michael E.; Lunking, David M.] US Army Res Lab, Sensors & Elect Devices Directorate, Adelphi, MD 20783 USA.
[Currano, Luke J.] Johns Hopkins Univ, Appl Phys Lab, Laurel, MD 20723 USA.
RP Piekiel, NW (reprint author), US Army Res Lab, Sensors & Elect Devices Directorate, Adelphi, MD 20783 USA.
EM nicholas.piekiel.ctr@mail.mil
FU Oak Ridge Associated Universities (ORAU)
FX The authors would like to thank Collin Becker for useful discussions
throughout this work, and Brian Isaacson for assistance in sample
fabrication. We would also like to thank Oak Ridge Associated
Universities (ORAU) for funding for this project.
NR 39
TC 8
Z9 8
U1 1
U2 28
PU WILEY-V C H VERLAG GMBH
PI WEINHEIM
PA POSTFACH 101161, 69451 WEINHEIM, GERMANY
SN 0721-3115
EI 1521-4087
J9 PROPELL EXPLOS PYROT
JI Propellants Explos. Pyrotech.
PD FEB
PY 2015
VL 40
IS 1
BP 16
EP 26
DI 10.1002/prep.201400140
PG 11
WC Chemistry, Applied; Engineering, Chemical
SC Chemistry; Engineering
GA CC7LS
UT WOS:000350549700004
ER
PT J
AU Edla, S
Reisner, AT
Liu, JB
Convertino, VA
Carter, R
Reifman, J
AF Edla, Shwetha
Reisner, Andrew T.
Liu, Jianbo
Convertino, Victor A.
Carter, Robert, III
Reifman, Jaques
TI Is heart rate variability better than routine vital signs for
prehospital identification of major hemorrhage?
SO AMERICAN JOURNAL OF EMERGENCY MEDICINE
LA English
DT Article
ID TRAUMA PATIENTS; LIFESAVING INTERVENTIONS; PERIOD VARIABILITY; RATE
COMPLEXITY; COMBAT CASUALTIES; RATE RESPONSE; PREDICTION; MORTALITY;
TRANSPORT; CAUTIONS
AB Objective: During initial assessment of trauma patients, metrics of heart rate variability (HRV) have been associated with high- risk clinical conditions. Yet, despite numerous studies, the potential of HRV to improve clinical outcomes remains unclear. Our objectivewas to evaluate whether HRV metrics provide additional diagnostic information, beyond routine vital signs, for making a specific clinical assessment: identification of hemorrhaging patients who receive packed red blood cell (PRBC) transfusion.
Methods: Adult prehospital trauma patients were analyzed retrospectively, excluding those who lacked a complete set of reliable vital signs and a clean electrocardiogram for computation of HRV metrics. We also excluded patients who did not survive to admission. The primary outcome was hemorrhagic injury plus different PRBC transfusion volumes. We performed multivariate regression analysis using HRV metrics and routine vital signs to test the hypothesis that HRV metrics could improve the diagnosis of hemorrhagic injury plus PRBC transfusion vs routine vital signs alone.
Results: As univariate predictors, HRV metrics in a data set of 402 subjects had comparable areas under receiver operating characteristic curves compared with routine vital signs. In multivariate regression models containing routine vital signs, HRV parameters were significant (P<.05) but yielded areas under receiver operating characteristic curves with minimal, nonsignificant improvements (+0.00 to +0.05).
Conclusions: A novel diagnostic test should improve diagnostic thinking and allowfor better decision making in a significant fraction of cases. Our findings do not support that HRV metrics add value over routine vital signs in terms of prehospital identification of hemorrhaging patients who receive PRBC transfusion. Published by Elsevier Inc.
C1 [Edla, Shwetha; Liu, Jianbo; Reifman, Jaques] US Army, Med Res & Mat Command, Telemed & Adv Technol Res Ctr, Software Applicat Inst,Dept Def Biotechnol High P, Ft Detrick, MD 21702 USA.
[Reisner, Andrew T.] Massachusetts Gen Hosp, Dept Emergency Med, Boston, MA 02114 USA.
[Convertino, Victor A.; Carter, Robert, III] US Army, Inst Surg Res, Ft Sam Houston, TX 78234 USA.
RP Reifman, J (reprint author), US Army, Med Res & Mat Command, Telemed & Adv Technol Res Ctr, ATTN MCMR TT,Software Applicat Inst,Dept Def Biot, 504 Scott St, Ft Detrick, MD 21702 USA.
EM jaques.reifman.civ@mail.mil
FU US Department of Defense Medical Research and Development Program
[D10_I_AR_J6_773]; Combat Casualty Care Research Area Directorate of the
US Army Medical Research and Materiel Command, Fort Detrick, MD, USA
FX This work was supported by the US Department of Defense Medical Research
and Development Program (grant no. D10_I_AR_J6_773) and by the Combat
Casualty Care Research Area Directorate of the US Army Medical Research
and Materiel Command, Fort Detrick, MD, USA. The study sponsors did not
have any role in the study design, data collection, analysis and
interpretation of data, report writing, or the decision to submit the
article for publication. The opinions and assertions contained herein
are the private views of the authors and are not to be construed as
official or as reflecting the views of the US Army or of the US
Department of Defense. This article has been approved for public release
with unlimited distribution.
NR 42
TC 2
Z9 2
U1 0
U2 0
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0735-6757
EI 1532-8171
J9 AM J EMERG MED
JI Am. J. Emerg. Med.
PD FEB
PY 2015
VL 33
IS 2
BP 254
EP 261
DI 10.1016/j.ajem.2014.11.046
PG 8
WC Emergency Medicine
SC Emergency Medicine
GA CC6AW
UT WOS:000350447900022
PM 25534122
ER
PT J
AU Larentzos, JP
Rice, BM
Byrd, EFC
Weingarten, NS
Lill, JV
AF Larentzos, James P.
Rice, Betsy M.
Byrd, Edward F. C.
Weingarten, N. Scott
Lill, James V.
TI Parameterizing Complex Reactive Force Fields Using Multiple Objective
Evolutionary Strategies (MOES). Part 1: ReaxFF Models for
Cyclotrimethylene Trinitramine (RDX) and 1,1-Diamino-2,2-dinitroethene
(FOX-7)
SO JOURNAL OF CHEMICAL THEORY AND COMPUTATION
LA English
DT Article
ID MOLECULAR-DYNAMICS SIMULATIONS; NEURAL-NETWORKS; THERMAL-DECOMPOSITION;
MULTIOBJECTIVE OPTIMIZATION; INTERMOLECULAR INTERACTIONS; ALGORITHMS;
HYDROCARBONS; STATE; SILICON; CARBON
AB ReaxFF (van Duin, A.C.T.; Dasgupta, S.; Lorant, F.; Goddard, W.A. J. Phys. Chem. A, 2001, 105, 9396-9409) reactive potentials are parametrized for cyclotrimethylene trinitramine (RDX) and 1,1-diamino-2,2-dinitroethene (FOX-7) in a novel application combining data envelopment analysis and a modern self-adaptive evolutionary algorithm to optimize multiple objectives simultaneously and map the entire family of solutions. In order to correct the poor crystallographic parameters predicted by ReaxFF using its base parametrization (Strachan, A.; van Duin, A. C. T.; Chakraborty, D.; Dasgupta S.; Goddard, W. A. Phys. Rev. Lett., 2003, 91, 098301), we augmented the existing training set data used for parametrization with additional (SAPT)DFT calculations of RDX and FOX-7 dimer interactions. By adjusting a small subset of the ReaxFF parameters that govern long-range interactions, the evolutionary algorithm approach converges on a family of solutions that best describe crystallographic parameters through simultaneous optimization of the objective functions. Molecular dynamics calculations of RDX and FOX-7 are conducted to assess the quality of the force fields, resulting in parametrizations that improve the overall prediction of the crystal structures.
C1 [Larentzos, James P.] US Army Res Lab, Engil Corp, High Technol Serv Grp, Aberdeen Proving Ground, MD 21005 USA.
[Rice, Betsy M.; Byrd, Edward F. C.; Weingarten, N. Scott] US Army Res Lab, Energet Mat Sci Branch, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA.
[Lill, James V.] US Air Force Res Lab, Engil Corp, High Technol Serv Grp, Wright Patterson AFB, OH 45433 USA.
RP Weingarten, NS (reprint author), US Army Res Lab, Energet Mat Sci Branch, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA.
EM neil.s.weingarten.civ@mail.mil
FU Department of Defense HPCMP Software Application Institute for
Multiscale Reactive Modeling of Insensitive Munitions
FX The authors acknowledge Dr. Anthony Yau for insightful discussions
regarding ReaxFF and his help in developing the MOES software.
Additionally, the authors gratefully acknowledge Prof. Adri van Duin of
Penn State University who generously provided a copy of his reac program
that served as the basis for the ReaxFF training set used by MOBS and
who offered guidance through numerous insightful discussions. The
authors also thank Dr. Shawn Brown of the Pittsburgh Supercomputing
Center who performed the initial MPI parallelization of MOBS. The
authors acknowledge the computational resources and PETTT software
support from the DoD High Performance Computing Modernization Program
(HPCMP). The HPCMP provided the supercomputing resources under a
Computing Challenge Project entitled, "Construction of Accurate Reactive
Potentials for Large Scale Molecular Dynamics Simulations." This time
was made available at the DoD Supercomputing Resource Centers at the
U.S. Army Research Laboratory, Air Force Research Laboratory, and
Engineer Research and Development Center. The authors acknowledge
support by the Department of Defense HPCMP Software Application
Institute for Multiscale Reactive Modeling of Insensitive Munitions.
NR 59
TC 10
Z9 10
U1 3
U2 40
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 1549-9618
EI 1549-9626
J9 J CHEM THEORY COMPUT
JI J. Chem. Theory Comput.
PD FEB
PY 2015
VL 11
IS 2
BP 381
EP 391
DI 10.1021/ct500788c
PG 11
WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical
SC Chemistry; Physics
GA CB9EI
UT WOS:000349934400003
PM 26580902
ER
PT J
AU Rice, BM
Larentzos, JP
Byrd, EFC
Weingarten, NS
AF Rice, Betsy M.
Larentzos, James P.
Byrd, Edward F. C.
Weingarten, N. Scott
TI Parameterizing Complex Reactive Force Fields Using Multiple Objective
Evolutionary Strategies (MOES): Part 2: Transferability of ReaxFF Models
to C-H-N-O Energetic Materials
SO JOURNAL OF CHEMICAL THEORY AND COMPUTATION
LA English
DT Article
ID MULTIOBJECTIVE DECISION-MAKING; POST-PARETO OPTIMALITY;
CRYSTAL-STRUCTURE; MOLECULAR-DYNAMICS; SIMULATIONS;
1,3,5-TRIAMINO-2,4,6-TRINITROBENZENE
AB The Multiple Objective Evolutionary Strategies (MOES) algorithm was used to parametrize force fields having the form of the reactive models ReaxFF (van Duin, A. C. T.; Dasgupta, S.; Lorant, F.; Goddard, W. A. J. Phys. Chem. A 2001, 105, 9396) and ReaxFF-lg (Liu, L.; Liu, Y.; Zybin, S. V.; Sun, H.; Goddard, W. A. J. Phys. Chem. A 2011, 115, 11016) in an attempt to produce equal or superior ambient state crystallographic structural results for cyclotrimethylene trinitramine (RDX). Promising candidates were then subjected to molecular dynamics simulations of five other well-known conventional energetic materials to assess the degree of transferability of the models. Two models generated through the MOES search were shown to have performance better than or as good as ReaxFF-lg in describing the six energetic systems modeled. This study shows that MOES is an effective and efficient method to develop complex force fields.
C1 [Rice, Betsy M.; Byrd, Edward F. C.; Weingarten, N. Scott] US Army Res Lab, Energet Mat Sci Branch, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA.
[Larentzos, James P.] US Army Res Lab, Engil Corp, High Technol Serv Grp, Aberdeen Proving Ground, MD 21005 USA.
RP Weingarten, NS (reprint author), US Army Res Lab, Energet Mat Sci Branch, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA.
EM neil.s.weingarten.civ@mail.mil
FU Department of Defense (DOD) High Performance Computing Modernization
Program (HCPMP) Software Application Institute for Multiscale Reactive
Modeling of Insensitive Munitions; DOD HPCMP Challenge award
FX This research was supported by the Department of Defense (DOD) High
Performance Computing Modernization Program (HCPMP) Software Application
Institute for Multiscale Reactive Modeling of Insensitive Munitions and
a DOD HPCMP Challenge award. All calculations were performed on the DOD
Supercomputer Resource Centers at ARL, ERDC, AFRL, and MHPCC.
NR 27
TC 9
Z9 9
U1 2
U2 33
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 1549-9618
EI 1549-9626
J9 J CHEM THEORY COMPUT
JI J. Chem. Theory Comput.
PD FEB
PY 2015
VL 11
IS 2
BP 392
EP 405
DI 10.1021/ct5007899
PG 14
WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical
SC Chemistry; Physics
GA CB9EI
UT WOS:000349934400004
PM 26580903
ER
PT J
AU Elward, JM
Chakraborty, A
AF Elward, Jennifer M.
Chakraborty, Arindam
TI Effect of Heterojunction on Exciton Binding Energy and Electron-Hole
Recombination Probability in CdSe/ZnS Quantum Dots
SO JOURNAL OF CHEMICAL THEORY AND COMPUTATION
LA English
DT Article
ID SENSITIZED SOLAR-CELLS; LIGHT-EMITTING-DIODES; DENSITY-FUNCTIONAL
THEORY; CHARGE SEPARATION; MULTIEXCITON GENERATION; HYDROGEN GENERATION;
MAGNETIC-FIELDS; SEMICONDUCTOR NANOCRYSTALS; OPTICAL RECTIFICATION;
COMPUTATIONAL METHODS
AB Presence of heterojunctions is important for generation of free charge carriers and the dissociation of bound electronhole pairs in semiconductor nanoparticles. This work presents a theoretical investigation of the effect of core/shell heterojunction on electronhole interaction in CdSe/ZnS quantum dots. The excitonic wave function in the CdSe/ZnS dots was calculated using the electronhole explicitly correlated HartreeFock (eh-XCHF) method and the effect of successive addition of the ZnS shell on exciton binding energy, electronhole recombination probability, and the electronhole separation distance was investigated. It was found that the scaling of all the three quantities as a function of dot diameter did not follow conventional volume scaling laws of core-only dots, and the scaling laws were significantly altered due to the presence of the heterojunction. The spatial localization of the quasiparticles in the core/shell quantum dot was analyzed by calculating the 1-particle reduced density from the eh-XCHF wave function and partitioning the density spatially into core and shell regions. It was found that in the 15 nm CdSe/ZnS dot, the relative probability of the electron localization in the shell region was higher than the hole by a factor of 3. The degree of spatial localization of the quasiparticles was found to depend strongly on the initial size of the CdSe core in the core/shell quantum dot. It was found that a reduction in the CdSe core diameter by a factor of 1.7 resulted in an enhancement of the preferential localization of the electron in the shell region by a factor of 11.3. The results demonstrate that large CdSe/ZnS quantum dots with a small CdSe core have the necessary characteristics for efficient exciton dissociation and generation of free charge carriers.
C1 [Elward, Jennifer M.] Army Res Lab, Aberdeen, MD 21005 USA.
[Chakraborty, Arindam] Syracuse Univ, Dept Chem, Syracuse, NY 13244 USA.
RP Chakraborty, A (reprint author), Syracuse Univ, Dept Chem, Syracuse, NY 13244 USA.
EM archakra@syr.edu
FU Syracuse University; National Science Foundation (NSF) CAREER
[CHE-1349892]; National Science Foundation [ACI-1053575]
FX We gratefully acknowledge financial support from Syracuse University and
National Science Foundation (NSF) CAREER Award CHE-1349892. This work
also used the Extreme Science and Engineering Discovery Environment
(XSEDE), which is supported by National Science Foundation grant number
ACI-1053575.
NR 138
TC 4
Z9 4
U1 5
U2 30
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 1549-9618
EI 1549-9626
J9 J CHEM THEORY COMPUT
JI J. Chem. Theory Comput.
PD FEB
PY 2015
VL 11
IS 2
BP 462
EP 471
DI 10.1021/ct500548x
PG 10
WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical
SC Chemistry; Physics
GA CB9EI
UT WOS:000349934400010
PM 26580906
ER
PT J
AU Qian, JF
Henderson, WA
Xu, W
Bhattacharya, P
Engelhard, M
Borodin, O
Zhang, JG
AF Qian, Jiangfeng
Henderson, Wesley A.
Xu, Wu
Bhattacharya, Priyanka
Engelhard, Mark
Borodin, Oleg
Zhang, Ji-Guang
TI High rate and stable cycling of lithium metal anode
SO NATURE COMMUNICATIONS
LA English
DT Article
ID ELECTROLYTE-SOLUTIONS; RECHARGEABLE BATTERIES; IONIC LIQUIDS;
ELECTROCHEMICAL PROPERTIES; CARBONATE SOLVENTS; APROTIC-SOLVENTS; SALT
ELECTROLYTE; PHASE-BEHAVIOR; STABILITY; MECHANISM
AB Lithium metal is an ideal battery anode. However, dendrite growth and limited Coulombic efficiency during cycling have prevented its practical application in rechargeable batteries. Herein, we report that the use of highly concentrated electrolytes composed of ether solvents and the lithium bis(fluorosulfonyl) imide salt enables the high-rate cycling of a lithium metal anode at high Coulombic efficiency (up to 99.1%) without dendrite growth. With 4M lithium bis(fluorosulfonyl) imide in 1,2-dimethoxyethane as the electrolyte, a lithium|lithium cell can be cycled at 10mA cm(-2) for more than 6,000 cycles, and a copper|lithium cell can be cycled at 4mA cm(-2) for more than 1,000 cycles with an average Coulombic efficiency of 98.4%. These excellent performances can be attributed to the increased solvent coordination and increased availability of lithium ion concentration in the electrolyte. Further development of this electrolyte may enable practical applications for lithium metal anode in rechargeable batteries.
C1 [Qian, Jiangfeng; Henderson, Wesley A.; Xu, Wu; Zhang, Ji-Guang] Joint Ctr Energy Storage Res, Argonne, IL 60439 USA.
[Qian, Jiangfeng; Henderson, Wesley A.; Xu, Wu; Bhattacharya, Priyanka; Zhang, Ji-Guang] Pacific NW Natl Lab, Energy & Environm Directorate, Richland, WA 99352 USA.
[Engelhard, Mark] Pacific NW Natl Lab, Environm & Mol Sci Lab, Richland, WA 99352 USA.
[Borodin, Oleg] US Army Res Lab, Sensor & Elect Devices Directorate, Electrochem Branch, Adelphi, MD 20783 USA.
RP Zhang, JG (reprint author), Joint Ctr Energy Storage Res, Argonne, IL 60439 USA.
EM jiguang.zhang@pnnl.gov
RI Borodin, Oleg/B-6855-2012;
OI Borodin, Oleg/0000-0002-9428-5291; Engelhard, Mark/0000-0002-5543-0812;
Xu, Wu/0000-0002-2685-8684
FU Joint Center for Energy Storage Research; Energy Innovation Hub - U.S.
Department of Energy (DOE), Office of Science, Basic Energy Sciences;
DOE's Office of Biological and Environmental Research (BER); Linus
Pauling distinguished Postdoctoral Fellowship of PNNL; U.S. Army
Research Laboratory; DOE [DE-AC05-76RLO1830]
FX This work was supported as part of the Joint Center for Energy Storage
Research, an Energy Innovation Hub funded by the U.S. Department of
Energy (DOE), Office of Science, Basic Energy Sciences. The SEM and XPS
characterizations were conducted in the William R. Wiley Environmental
Molecular Sciences Laboratory (EMSL)-a national scientific user facility
located at PNNL that is sponsored by the DOE's Office of Biological and
Environmental Research (BER). P.B. and O.B. gratefully acknowledged
supports from the Linus Pauling distinguished Postdoctoral Fellowship of
PNNL and U.S. Army Research Laboratory, respectively. PNNL is operated
by Battelle for the DOE under Contract DE-AC05-76RLO1830. We thank Mark
Bowden of EMSL for his help on XRD measurement and Dr Masashi Yukitake
of Nippon Shokubai for supplying the LiFSI salt without charge.
NR 43
TC 123
Z9 123
U1 88
U2 442
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 2041-1723
J9 NAT COMMUN
JI Nat. Commun.
PD FEB
PY 2015
VL 6
AR 6362
DI 10.1038/ncomms7362
PG 9
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA CC4BL
UT WOS:000350295600001
PM 25698340
ER
PT J
AU Patil, RR
Turgman-Cohen, S
Srogl, J
Kiserow, D
Genzer, J
AF Patil, Rohan R.
Turgman-Cohen, Salomon
Srogl, Jiri
Kiserow, Douglas
Genzer, Jan
TI Direct Measurement of Molecular Weight and Grafting Density by
Controlled and Quantitative Degrafting of Surface-Anchored Poly(methyl
methacrylate)
SO ACS MACRO LETTERS
LA English
DT Article
ID CONTROLLED RADICAL POLYMERIZATION; COMPUTER-SIMULATION; FLAT SURFACES;
BRUSHES; ADSORPTION; BULK; ATRP
AB We report on quantitative determination of the molecular weight distribution (MWD) and grafting density (sigma(P)) of polymer assemblies grown by controlled radical polymerization from flat substrates as a function of polymerization time and the ratio between the inhibitor and catalyst species. Specifically, we grow poly(methyl methacrylate) (PMMA) brushes on flat silica-based surfaces by surface-initiated atom transfer radical polymerization (SI-ATRP), cleave the PMMA grafts quantitatively using tetrabutyl ammonium fluoride (TBAF), and analyze their MWD by size exclusion chromatography equipped with a high-sensitivity differential refractive index detector. The polymer growth and degrafting processes are followed by ellipsometry, X-ray photoelectron spectroscopy, and time-of-flight secondary ion mass spectrometry. The sigma(P) is independent of polymerization time and increases with increasing SI-ATRP inhibitor/catalyst ratio. Specifically, sigma(P) increases from 0.48 +/- 0.06 to 0.58 +/- 0.06 chains/nm(2) as the inhibitor/catalyst molar ratio increases from 0 to 0.015, respectively, providing evidence that high inhibitor/catalyst ratio offers better control of the SI-ATRP reaction, by lowering number of terminations, and leading to denser PMMA brush assemblies.
C1 [Patil, Rohan R.; Srogl, Jiri; Kiserow, Douglas; Genzer, Jan] N Carolina State Univ, Dept Chem & Biomol Engn, Raleigh, NC 27695 USA.
[Turgman-Cohen, Salomon] Kettering Univ, Dept Chem Engn, Flint, MI 48504 USA.
[Kiserow, Douglas] US Army Res Off, Res Triangle Pk, NC 27709 USA.
RP Genzer, J (reprint author), N Carolina State Univ, Dept Chem & Biomol Engn, Raleigh, NC 27695 USA.
EM jan_genzer@ncsu.edu
FU National Science Foundation [DMR-0906572]; Army Research Office under
Staff Research Program [W911NF-04-D-0003-0016]
FX The work was supported by the National Science Foundation (Grant no.
DMR-0906572) and the Army Research Office under their Staff Research
Program (Grant no. W911NF-04-D-0003-0016).
NR 29
TC 7
Z9 7
U1 9
U2 42
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 2161-1653
J9 ACS MACRO LETT
JI ACS Macro Lett.
PD FEB
PY 2015
VL 4
IS 2
BP 251
EP 254
DI 10.1021/mz5007188
PG 4
WC Polymer Science
SC Polymer Science
GA CB7NM
UT WOS:000349814100022
ER
PT J
AU Fresconi, F
Celmins, I
Silton, S
Costello, M
AF Fresconi, Frank
Celmins, Ilmars
Silton, Sidra
Costello, Mark
TI High maneuverability projectile flight using low cost components
SO AEROSPACE SCIENCE AND TECHNOLOGY
LA English
DT Article
DE Projectile; Guided flight; High maneuverability; Low cost
ID MISSILE AUTOPILOT DESIGN; GUIDANCE
AB This paper examines the problem of enhancing maneuverability of gun-launched munitions utilizing low cost technologies. Two ideas are proposed for reducing cost: (1) designing algorithms that reduce the sensor or actuator burden, and (2) performing high fidelity modeling and simulation of the entire system with realistic data input. The fundamental theory underpinning guided projectile flight systems, including nonlinear equations of motion for projectile flight, aerodynamic modeling, actuator dynamics, and measurement modeling, is outlined. Manipulation of these nonlinear models into linear system models enables airframe stability investigation and flight control design. A basic framework for low cost guidance, navigation, and control (GNC) of high maneuverability projectiles is formulated. Theory was implemented in simulation and exercised for a guided projectile system. Results support the hypothesis that algorithms can compensate for poor actuator performance and identified critical trade study parameters. Monte Carlo analysis indicated that the cost associated with measurements of a threshold accuracy rather than actuation technologies prescribes guided system performance. Published by Elsevier Masson SAS.
C1 [Fresconi, Frank; Celmins, Ilmars; Silton, Sidra] US Army Res Lab, Aberdeen Proving Ground, MD 21015 USA.
[Costello, Mark] Georgia Inst Technol, Atlanta, GA 30332 USA.
RP Fresconi, F (reprint author), US Army Res Lab, Aberdeen Proving Ground, MD 21015 USA.
EM frank.e.fresconi.civ@mail.mil
NR 21
TC 3
Z9 3
U1 0
U2 10
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI PARIS
PA 23 RUE LINOIS, 75724 PARIS, FRANCE
SN 1270-9638
EI 1626-3219
J9 AEROSP SCI TECHNOL
JI Aerosp. Sci. Technol.
PD FEB
PY 2015
VL 41
BP 175
EP 188
DI 10.1016/j.ast.2014.12.007
PG 14
WC Engineering, Aerospace
SC Engineering
GA CC1AR
UT WOS:000350073900021
ER
PT J
AU Gentili, RJ
Bradberry, TJ
Oh, H
Costanzo, ME
Kerick, SE
Contreras-Vidal, JL
Hatfield, BD
AF Gentili, Rodolphe J.
Bradberry, Trent J.
Oh, Hyuk
Costanzo, Michelle E.
Kerick, Scott E.
Contreras-Vidal, Jose L.
Hatfield, Bradley D.
TI Evolution of cerebral cortico-cortical communication during visuomotor
adaptation to a cognitive-motor executive challenge
SO BIOLOGICAL PSYCHOLOGY
LA English
DT Article
DE Cortico-cortical communications; Visuomotor adaptation learning; Frontal
executive; Electroencephalography; Arm movement; Frequency bands
ID ERROR-RELATED NEGATIVITY; HIGH-RESOLUTION EEG;
HEMISPHERIC-SPECIALIZATION; BIMANUAL MOVEMENTS; CORTICAL DYNAMICS;
NEURAL EFFICIENCY; SKILLED MARKSMEN; PHASE SYNCHRONY; WORKING-MEMORY;
FRONTAL-CORTEX
AB Cortical dynamics were examined during a cognitive-motor adaptation task that required inhibition of a familiar motor plan. EEG coherence between the motor planning (Fz) and left hemispheric region was progressively reduced over trials (low-beta, high-beta, gamma bands) along with faster, straighter reaching movements during both planning and execution. The major reduction in coherence (delta, low/high-theta, low/high-alpha bands) between Fz and the left prefrontal region during both movement planning and execution suggests gradual disengagement of frontal executive following its initial role in the suppression of established visuomotor maps. Also, change in the directionality of phase lags (delta, high-alpha, high-beta, gamma bands) reflects a progressive shift from feedback to feedforward motor control. The reduction of cortico-cortical communication, particularly in the frontal region, and the strategic feedback/feedforward mode shift translated as higher quality motor performance. This study extends our understanding of the role of frontal executive beyond purely cognitive tasks to cognitive-motor tasks. (C) 2014 Elsevier B.V. All rights reserved.
C1 [Gentili, Rodolphe J.; Oh, Hyuk; Hatfield, Bradley D.] Univ Maryland, Sch Publ Hlth, Dept Kinesiol, College Pk, MD 20742 USA.
[Gentili, Rodolphe J.; Oh, Hyuk; Costanzo, Michelle E.; Hatfield, Bradley D.] Univ Maryland, Grad Program Neurosci & Cognit Sci, College Pk, MD 20742 USA.
[Gentili, Rodolphe J.] Univ Maryland, Maryland Robot Ctr, College Pk, MD 20742 USA.
[Bradberry, Trent J.] Metron Inc, Reston, VA USA.
[Kerick, Scott E.] US Army Res Lab, Adelphi, MD USA.
[Contreras-Vidal, Jose L.] Univ Houston, Dept Elect & Comp Engn, Lab Noninvas Brain Machine Interface Syst, Houston, TX USA.
[Hatfield, Bradley D.] Univ Maryland, Sch Publ Hlth, Ctr Aging, College Pk, MD 20742 USA.
RP Gentili, RJ (reprint author), Univ Maryland, Sch Publ Hlth, Dept Kinesiol, Motor Neurosci Lab, Bldg 255, College Pk, MD 20742 USA.
EM rodolphe@umd.edu
FU La Fondation Motrice, Paris, France
FX R.J. Gentili was supported by La Fondation Motrice, Paris, France.
NR 74
TC 3
Z9 3
U1 0
U2 8
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0301-0511
EI 1873-6246
J9 BIOL PSYCHOL
JI Biol. Psychol.
PD FEB
PY 2015
VL 105
BP 51
EP 65
DI 10.1016/j.biopsycho.2014.12.003
PG 15
WC Psychology, Biological; Behavioral Sciences; Psychology; Psychology,
Experimental
SC Psychology; Behavioral Sciences
GA CB8WH
UT WOS:000349912100006
PM 25530479
ER
PT J
AU Spieker, EA
Sbrocco, T
Theim, KR
Maurer, D
Johnson, D
Bryant, E
Bakalar, JL
Schvey, NA
Ress, R
Seehusen, D
Klein, DA
Stice, E
Yanovski, JA
Chan, L
Gentry, S
Ellsworth, C
Hill, JW
Tanofsky-Kraff, M
Stephens, MB
AF Spieker, Elena A.
Sbrocco, Tracy
Theim, Kelly R.
Maurer, Douglas
Johnson, Dawn
Bryant, Edny
Bakalar, Jennifer L.
Schvey, Natasha A.
Ress, Rachel
Seehusen, Dean
Klein, David A.
Stice, Eric
Yanovski, Jack A.
Chan, Linda
Gentry, Shari
Ellsworth, Carol
Hill, Joanne W.
Tanofsky-Kraff, Marian
Stephens, Mark B.
TI Preventing Obesity in the Military Community (POMC): The Development of
a Clinical Trials Research Network
SO INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
LA English
DT Article
ID RANDOMIZED EFFICACY TRIAL; EATING-DISORDER; ADULT OBESITY; INTERPERSONAL
PSYCHOTHERAPY; DESERT-STORM; HIGH-RISK; METABOLIC SYNDROME; ADOLESCENT
GIRLS; WEIGHT-GAIN; BODY-WEIGHT
AB Obesity impacts the U.S. military by affecting the health and readiness of active duty service members and their families. Preventing Obesity in Military Communities (POMC) is a comprehensive research program within Patient Centered Medical Homes (PCMHs) in three Military Training Facilities. This paper describes three pilot randomized controlled trials that target critical high risk periods for unhealthy weight gain from birth to young adulthood: (1) pregnancy and early infancy (POMC-Mother-Baby), (2) adolescence (POMC-Adolescent), and (3) the first tour of duty after boot camp (POMC-Early Career). Each study employs a two-group randomized treatment or prevention program with follow up. POMC offers a unique opportunity to bring together research and clinical expertise in obesity prevention to develop state-of-the-art programs within PCMHs in Military Training Facilities. This research builds on existing infrastructure that is expected to have immediate clinical benefits to DoD and far-reaching potential for ongoing collaborative work. POMC may offer an economical approach for widespread obesity prevention, from conception to young adulthood, in the U.S. military as well as in civilian communities.
C1 [Spieker, Elena A.; Maurer, Douglas] Madigan Army Med Ctr, Dept Family Med, Tacoma, WA 98431 USA.
[Spieker, Elena A.; Sbrocco, Tracy; Theim, Kelly R.; Johnson, Dawn; Bryant, Edny; Bakalar, Jennifer L.; Schvey, Natasha A.; Ress, Rachel; Tanofsky-Kraff, Marian] Uniformed Serv Univ Hlth Sci, Dept Med & Clin Psychol, Bethesda, MD 20814 USA.
[Spieker, Elena A.; Theim, Kelly R.; Bakalar, Jennifer L.; Schvey, Natasha A.; Ress, Rachel] Henry M Jackson Fdn Adv Mil Med Inc, Bethesda, MD 20817 USA.
[Seehusen, Dean] Dept Family & Community Med, Ft Gordon, GA 30905 USA.
[Klein, David A.] Ft Belvoir Community Hosp, Dept Family Med, Ft Belvoir, VA 22060 USA.
[Stice, Eric] Oregon Res Inst, Eugene, OR 97403 USA.
[Yanovski, Jack A.; Tanofsky-Kraff, Marian] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Sect Growth & Obes, Program Dev Endocrinol & Genet, NIH,DHHS, Bethesda, MD 20892 USA.
[Chan, Linda] Naval Hosp Camp Lejeune, Dept Obstet & Gynecol, Camp Lejeune, NC 28547 USA.
[Gentry, Shari; Ellsworth, Carol] Naval Hosp Camp Lejeune, Dept Family Med, Camp Lejeune, NC 28547 USA.
[Hill, Joanne W.] Naval Hosp Camp Lejeune, Dept Res, Camp Lejeune, NC 28547 USA.
[Stephens, Mark B.] Uniformed Serv Univ Hlth Sci, Dept Family Med, Bethesda, MD 20814 USA.
RP Sbrocco, T (reprint author), Uniformed Serv Univ Hlth Sci, Dept Med & Clin Psychol, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA.
EM elena.a.spieker.ctr@mail.mil; tracy.sbrocco@usuhs.edu;
kelly.theim.ctr@usuhs.edu; douglas.m.maurer.mil@mail.mil;
dawn.johnson@usuhs.edu; edny.joseph@usuhs.edu;
Jennifer.bakalar@usuhs.edu; natasha.schvey.ctr@usuhs.edu;
rachel.ress.ctr@usuhs.edu; Dean.A.Seehusen.mil@health.mil;
david.a.klein26.mil@mail.mil; estice@ori.org; yanovskj@mail.nih.gov;
Linda.Chan@med.navy.mil; shari.gentry@med.navy.mil;
carol.ellsworth@med.navy.mil; Joanne.Hill@med.navy.mil;
marian.tanofsky-kraff@usuhs.edu; mark.stephens@usuhs.edu
OI Yanovski, Jack/0000-0001-8542-1637
FU Uniformed Services University [USUHS72NC-01]; NICHD [Z1aHD00641];
[F172NC-02]
FX Research support provided by a grant from the Uniformed Services
University (USUHS72NC-01) to Tracy Sbrocco and intramural support from
NICHD (Z1aHD00641) to Jack A. Yanovski, a Commissioned Officer in the
United States Public Health Service. This manuscript was developed
within the scope of work for the Henry M. Jackson Foundation for the
Advancement of Military Medicine, Inc., by authors Elena A. Spieker,
Kelly R. Theim supported by grant F172NC-02.
NR 57
TC 3
Z9 3
U1 2
U2 5
PU MDPI AG
PI BASEL
PA POSTFACH, CH-4005 BASEL, SWITZERLAND
SN 1660-4601
J9 INT J ENV RES PUB HE
JI Int. J. Environ. Res. Public Health
PD FEB
PY 2015
VL 12
IS 2
BP 1174
EP 1195
DI 10.3390/ijerph120201174
PG 22
WC Environmental Sciences; Public, Environmental & Occupational Health
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
Health
GA CC2XZ
UT WOS:000350209800008
PM 25648176
ER
PT J
AU Camacho, M
Zaghi, S
Certal, V
Abdullatif, J
Means, C
Acevedo, J
Liu, S
Brietzke, SE
Kushida, CA
Capasso, R
AF Camacho, Macario
Zaghi, Soroush
Certal, Victor
Abdullatif, Jose
Means, Casey
Acevedo, Jason
Liu, Stanley
Brietzke, Scott E.
Kushida, Clete A.
Capasso, Robson
TI Inferior Turbinate Classification System, Grades 1 to 4: Development and
Validation Study
SO LARYNGOSCOPE
LA English
DT Article
DE Turbinates; classification; nose; validation; hypertrophy
ID OBSTRUCTIVE SLEEP-APNEA; TONSILLAR SIZE; REDUCTION; KAPPA; HYPERTROPHY;
AGREEMENT
AB Objectives/Hypothesis: To develop a validated inferior turbinate grading scale.
Study Design: Development and validation study.
Methods: Phase 1 development (alpha test) consisted of a proposal of 10 different inferior turbinate grading scales (>1,000 clinic patients). Phase 2 validation (beta test) utilized 10 providers grading 27 standardized endoscopic photos of inferior turbinates using two different classification systems. Phase 3 validation (pilot study) consisted of 100 live consecutive clinic patients (n=200 inferior turbinates) who were each prospectively graded by 18 different combinations of two independent raters, and grading was repeated by each of the same two raters, two separate times for each patient.
Results: In the development phase, 25% (grades 1-4) and 33% (grades 1-4) were the most useful systems. In the validation phase, the 25% classification system was found to be the best balance between potential clinical utility and ability to grade; the photo grading demonstrated a Cohen's kappa (kappa) = 0.4671 +/- 0.0082 (moderate inter-rater agreement). Live-patient grading with the 25% classification system demonstrated an overall inter-rater reliability of 71.5% (95% confidence interval [CI]: 64.8-77.3), with overall substantial agreement (kappa = 0.704 +/- 0.028). Intrarater reliability was 91.5% (95% CI: 88.7-94.3). Distribution for the 200 inferior turbinates was as follows: 25% quartile = grade 1, 50% quartile (median) = grade 2, 75% quartile = grade 3, and 90% quartile = grade 4. Mean turbinate size was 2.22 (95% CI: 2.07-2.34; standard deviation 1.02). Categorical kappa was as follows: grade 1, 0.8541 +/- 0.0289; grade 2, 0.7310 +/- 0.0289; grade 3, 0.6997 +/- 0.0289, and grade 4, 0.7760 +/- 0.0289.
Conclusions: The 25% (grades 1-4) inferior turbinate classification system is a validated grading scale with high intra-rater and inter-rater reliability. This system can facilitate future research by tracking the effect of interventions on inferior turbinates.
C1 [Camacho, Macario] Stanford Outpatient Med Ctr, Sleep Med Div, Dept Psychiat, Redwood City, CA USA.
[Zaghi, Soroush] Univ Calif Los Angeles, Dept Head & Neck Surg, Los Angeles, CA USA.
[Certal, Victor] Hosp Lusiadas, Dept Otorhinolaryngol, Oporto, Portugal.
[Certal, Victor] Univ Porto, CINTESIS Ctr Res Hlth Technol & Informat Syst, P-4100 Oporto, Portugal.
[Abdullatif, Jose] Hosp Bernardino Rivadavia, Dept Otorhinolaryngol, Buenos Aires, DF, Argentina.
[Means, Casey] Stanford Sch Med, Stanford, CA USA.
[Abdullatif, Jose] Reynolds Army Community Hosp, Ft Sill, OK USA.
[Liu, Stanley] Stanford Univ, Med Ctr, Sleep Surg Div, Dept Otolaryngol Head & Neck Surg, Stanford, CA 94305 USA.
[Brietzke, Scott E.] Walter Reed Natl Mil Med Ctr, Dept Otolaryngol Head & Neck Surg, Bethesda, MD USA.
[Kushida, Clete A.] Stanford Hosp & Clin, Div Sleep Med, Dept Psychiat, Redwood City, CA 94063 USA.
[Capasso, Robson] Stanford Univ, Med Ctr, Sleep Surg Div, Dept Otolaryngol Head & Neck Surg, Stanford, CA 94305 USA.
RP Camacho, M (reprint author), Stanford Hosp & Clin, Stanford Outpatient Med Ctr, Sleep Med Div, Dept Psychiat, 2nd Floor,450 Broadway St, Redwood City, CA 94063 USA.
EM drcamachoent@yahoo.com
RI FMUP, CINTESIS/C-6631-2014;
OI FMUP, CINTESIS/0000-0001-7248-2086; Certal, Victor/0000-0002-1904-9504;
Camacho, Macario/0000-0001-9200-9085
NR 22
TC 14
Z9 14
U1 0
U2 1
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0023-852X
EI 1531-4995
J9 LARYNGOSCOPE
JI Laryngoscope
PD FEB
PY 2015
VL 125
IS 2
BP 296
EP 302
DI 10.1002/lary.24923
PG 7
WC Medicine, Research & Experimental; Otorhinolaryngology
SC Research & Experimental Medicine; Otorhinolaryngology
GA CB9SS
UT WOS:000349973400016
PM 25215619
ER
PT J
AU Baldwin, KM
Ehrenberg, PK
Geretz, A
Prentice, HA
Nitayaphan, S
Rerks-Ngarm, S
Kaewkungwal, J
Pitisuttithum, P
O'Connell, RJ
Kim, JH
Thomas, R
AF Baldwin, K. M.
Ehrenberg, P. K.
Geretz, A.
Prentice, H. A.
Nitayaphan, S.
Rerks-Ngarm, S.
Kaewkungwal, J.
Pitisuttithum, P.
O'Connell, R. J.
Kim, J. H.
Thomas, R.
TI HLA class II diversity in HIV-1 uninfected individuals from the placebo
arm of the RV144 Thai vaccine efficacy trial
SO TISSUE ANTIGENS
LA English
DT Article
DE HIV-1; Human leukocyte antigen; HLA-DPB1; HLA-DQB1; HLA-DRB1; RV144
ID HAPLOTYPE FREQUENCIES; ANTIBODY-RESPONSE; ALLELES; POPULATION; HLA-DRB1;
ANTIGEN; POLYMORPHISM; MOLECULES; INFECTION; GENES
AB The RV144 HIV vaccine trial in Thailand elicited antibody responses to the envelope of HIV-1, which correlated significantly with the risk of HIV-1 acquisition. Human leukocyte antigen (HLA) class II molecules are essential in antigen presentation to CD4 T cells for activation of B cells to produce antibodies. We genotyped the classical HLA-DRB1, DQB1, and DPB1 genes in 450 individuals from the placebo arm of the RV144 study to determine the background allele and haplotype frequencies of these genes in this cohort. High-resolution 4 and 6-digit class II HLA typing data was generated using sequencing-based methods. The observed diversity for the HLA loci was 33 HLA-DRB1, 15 HLA-DQB1, and 26 HLA-DPB1 alleles. Common alleles with frequencies greater than 10% were DRB1*07:01, DRB1*09:01, DRB1*12:02, DRB1*15:02, DQB1*02:01/02, DQB1*03:01, DQB1*03:03, DQB1*05:01, DQB1*05:02, DPB1*04:01:01, DPB1*05:01:01, and DPB1*13:01:01. We identified 28 rare alleles with frequencies of less than 1% in the Thai individuals. Ambiguity for HLA-DPB1*28:01 in exon 2 was resolved to DPB1*296:01 by next-generation sequencing of all exons. Multi-locus haplotypes including HLA class I and II loci were reported in this study. This is the first comprehensive report of allele and haplotype frequencies of all three HLA class II genes from a Thai population. A high-resolution genotyping method such as next-generation sequencing avoids missing rare alleles and resolves ambiguous calls. The HLA class II genotyping data generated in this study will be beneficial not only for future disease association/vaccine efficacy studies related to the RV144 study, but also for similar studies in other diseases in the Thai population, as well as population genetics and transplantation studies.
C1 [Baldwin, K. M.; Ehrenberg, P. K.; Geretz, A.; Kim, J. H.; Thomas, R.] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD 20910 USA.
[Baldwin, K. M.; Geretz, A.; Prentice, H. A.; Thomas, R.] Henry M Jackson Fdn Adv Mil Med, Bethesda, MD USA.
[Nitayaphan, S.; O'Connell, R. J.] AFRIMS, US Army Med Component, Dept Retrovirol, Bangkok, Thailand.
[Rerks-Ngarm, S.] Minist Publ Hlth, Dept Dis Control, Nonthaburi, Thailand.
[Kaewkungwal, J.] Mahidol Univ, Fac Trop Med, Ctr Excellence Biomed & Publ Hlth Informat BIOPHI, Bangkok, Thailand.
[Pitisuttithum, P.] Mahidol Univ, Fac Trop Med, Vaccine Trials Ctr, Bangkok, Thailand.
RP Thomas, R (reprint author), Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD 20910 USA.
EM rthomas@hivresearch.org
FU Henry M. Jackson Foundation for the Advancement of Military Medicine,
Inc. [W81XWH-07-2-0067]; U.S. Department of Defense (DOD)
[W81XWH-07-2-0067]; U.S. National Institute of Allergy and Infectious
Disease
FX This work was supported by a cooperative agreement (W81XWH-07-2-0067)
between the Henry M. Jackson Foundation for the Advancement of Military
Medicine, Inc., and the U.S. Department of Defense (DOD). This research
was funded, in part, by the U.S. National Institute of Allergy and
Infectious Disease. The views expressed are those of the authors and
should not be construed to represent the positions of the U.S. Army or
the DOD. We would like to thank Dr. Richard Apps (NCI-Frederick) for the
helpful comments.
NR 31
TC 2
Z9 2
U1 0
U2 3
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0001-2815
EI 1399-0039
J9 TISSUE ANTIGENS
JI Tissue Antigens
PD FEB
PY 2015
VL 85
IS 2
BP 117
EP 126
DI 10.1111/tan.12507
PG 10
WC Cell Biology; Immunology; Pathology
SC Cell Biology; Immunology; Pathology
GA CA6OH
UT WOS:000349033700005
PM 25626602
ER
PT J
AU Eichfeld, SM
Hossain, L
Lin, YC
Piasecki, AF
Kupp, B
Birdwell, AG
Burke, RA
Lu, N
Peng, X
Li, J
Azcatl, A
McDonnell, S
Wallace, RM
Kim, MJ
Mayer, TS
Redwing, JM
Robinson, JA
AF Eichfeld, Sarah M.
Hossain, Lorraine
Lin, Yu-Chuan
Piasecki, Aleksander F.
Kupp, Benjamin
Birdwell, A. Glen
Burke, Robert A.
Lu, Ning
Peng, Xin
Li, Jie
Azcatl, Angelica
McDonnell, Stephen
Wallace, Robert M.
Kim, Moon J.
Mayer, Theresa S.
Redwing, Joan M.
Robinson, Joshua A.
TI Highly Scalable, Atomically Thin WSe2 Grown via Metal-Organic Chemical
Vapor Deposition
SO ACS NANO
LA English
DT Article
DE tungsten diselenide; WSe2; metal organic chemical vapor deposition
(MOCVD); transition-metal dichalcogenide; graphene; synthesis;
two-dimensional (2D) materials
ID SINGLE-LAYER; TUNGSTEN DISELENIDE; MONOLAYER MOS2; FILMS; WS2;
HETEROSTRUCTURES; SHEETS; MONO; DICHALCOGENIDES; DISULFIDES
AB Tungsten diselenide (WSe2) is a two-dimensional material that is of interest for next-generation electronic and optoelectronic devices due to its direct bandgap of 1.65 eV in the monolayer form and excellent transport properties. However, technologies based on this 2D material cannot be realized without a scalable synthesis process. Here, we demonstrate the first scalable synthesis of large-area, mono and few-layer WSe2 via metalorganic chemical vapor deposition using tungsten hexacarbonyl (W(CO)(6)) and dimethylselenium ((CH3)(2)Se). In addition to being intrinsically scalable, this technique allows for the precise control of the vapor-phase chemistry, which is unobtainable using more traditional oxide vaporization routes. We show that temperature, pressure, Se:W ratio, and substrate choice have a strong impact on the ensuing atomic layer structure, with optimized conditions yielding >8 mu m size domains. Raman spectroscopy, atomic force microscopy (AFM), and cross-sectional transmission electron microscopy (TEM) confirm crystalline monoto-multilayer WSe2 is achievable. Finally, TEM and vertical current/voltage transport provide evidence that a pristine van der Waals gap exists in WSe2/graphene heterostructures.
C1 [Eichfeld, Sarah M.; Hossain, Lorraine; Lin, Yu-Chuan; Piasecki, Aleksander F.; Kupp, Benjamin; Redwing, Joan M.; Robinson, Joshua A.] Penn State Univ, Dept Mat Sci & Engn, University Pk, PA 16802 USA.
[Eichfeld, Sarah M.; Hossain, Lorraine; Lin, Yu-Chuan; Piasecki, Aleksander F.; Kupp, Benjamin; Mayer, Theresa S.; Redwing, Joan M.; Robinson, Joshua A.] Penn State Univ, Ctr Two Dimens & Layered Mat, University Pk, PA 16802 USA.
[Li, Jie; Mayer, Theresa S.] Penn State Univ, Dept Elect Engn, University Pk, PA 16802 USA.
[Lu, Ning; Peng, Xin; Azcatl, Angelica; McDonnell, Stephen; Wallace, Robert M.; Kim, Moon J.] Univ Texas Dallas, Dept Mat Sci & Engn, Richardson, TX 75080 USA.
[Birdwell, A. Glen; Burke, Robert A.] US Army Res Lab, Adelphi, MD 20783 USA.
RP Robinson, JA (reprint author), Penn State Univ, Dept Mat Sci & Engn, University Pk, PA 16802 USA.
EM jrobinson@psu.edu
RI Lu, Ning/H-2351-2012; McDonnell, Stephen/E-1868-2011; Kim,
Moon/A-2297-2010; Wallace, Robert/A-5283-2008
OI McDonnell, Stephen/0000-0001-9173-2060; Wallace,
Robert/0000-0001-5566-4806
FU Center for Low Energy Systems Technology (LEAST), one of six centers -
STARnet phase of the Focus Center Research Program (FCRP); Semiconductor
Research Corporation (SRC) program - MARCO; DARPA; Southwest Academy on
Nanoelectronics (SWAN); SRC center - Nanoelectronics Research
Initiative; NIST; National Science Foundation [ECS-0335765]
FX We thank N. R. Glavin and A. A. Voevodin of the Nanoelectronic Materials
Branch, Air Force Research Laboratory, Wright-Patterson AFB, Dayton, OH,
for providing BN/sapphire substrates for synthesis. The work at Penn
State and UT Dallas was supported by the Center for Low Energy Systems
Technology (LEAST), one of six centers supported by the STARnet phase of
the Focus Center Research Program (FCRP), a Semiconductor Research
Corporation (SRC) program sponsored by MARCO and DARPA. Work at UT
Dallas was also supported by the Southwest Academy on Nanoelectronics
(SWAN), a SRC center sponsored by the Nanoelectronics Research
Initiative and NIST. The work at the U.S. Army Research Laboratory (ARL)
was supported by the Director's Strategic Initiative (DSI) program on
interfaces in stacked 2D atomic layered materials. Device fabrication
was partially supported by the Pennsylvania State University Materials
Research Institute Nanofabrication Laboratory and the National Science
Foundation Cooperative Agreement No. ECS-0335765.
NR 49
TC 41
Z9 41
U1 26
U2 226
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 1936-0851
EI 1936-086X
J9 ACS NANO
JI ACS Nano
PD FEB
PY 2015
VL 9
IS 2
BP 2080
EP 2087
DI 10.1021/nn5073286
PG 8
WC Chemistry, Multidisciplinary; Chemistry, Physical; Nanoscience &
Nanotechnology; Materials Science, Multidisciplinary
SC Chemistry; Science & Technology - Other Topics; Materials Science
GA CB9GR
UT WOS:000349940500104
PM 25625184
ER
PT J
AU Ranade, R
Li, VC
Heard, WF
AF Ranade, Ravi
Li, Victor C.
Heard, William F.
TI Tensile Rate Effects in High Strength-High Ductility Concrete
SO CEMENT AND CONCRETE RESEARCH
LA English
DT Article
DE Strain effect; Mechanical properties; Micromechanics; High-performance
concrete; Composite
ID ENGINEERED CEMENTITIOUS COMPOSITES; STRAIN-RATE; COMPRESSIVE BEHAVIOR;
FRACTURE; IMPACT; MODEL
AB Researchers at the University of Michigan have recently developed a new class of concrete, named High Strength-High Ductility Concrete (HSHDC), which possesses exceptional combination of compressive strength (>150 MPa) and tensile ductility (>3%) under quasi-static loads. The structural applications of HSHDC for withstanding extreme events, such as hurricanes, earthquakes, impacts, and blasts, require an understanding of its dynamic behavior at high strain rates. This research experimentally investigates the effects of strain rate (from 10(-4)/s to 10/s) on the composite tensile properties and the micro-scale fiber/matrix interaction properties of HSHDC. A micromechanics-based scale-linking model is used to analytically explain the composite-scale rate effects based on the micro-scale rate effects. Due to the unique interactions between the Polyethylene fibers and densely packed ultra-high strength matrix of HSHDC, novel rate effects are revealed, which are expected to be foundational for the future development of this class of materials for improving infrastructure resilience. (C) 2014 Elsevier Ltd. All rights reserved.
C1 [Ranade, Ravi] SUNY Buffalo, Dept Civil Struct & Environm Engn, Inst Bridge Engn, Buffalo, NY 14260 USA.
[Li, Victor C.] Univ Michigan, Dept Civil & Environm Engn, Ann Arbor, MI 48109 USA.
[Heard, William F.] US Army, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA.
RP Li, VC (reprint author), Univ Michigan, Dept Civil & Environm Engn, 2350 Hayward St, Ann Arbor, MI 48109 USA.
EM vcli@umich.edu
RI Ranade, Ravi/I-6387-2013;
OI Ranade, Ravi/0000-0001-6030-8371; Li, Victor/0000-0002-8678-3493
FU U.S. Army ERDC, Vicksburg, MS [W912HZ-08-C-0056]
FX This research at the University of Michigan was supported by a research
contract (W912HZ-08-C-0056) from the U.S. Army ERDC, Vicksburg, MS.
Helpful discussions with T. Rushing, T. Slawson, B. Williams, and J.
Davis of ERDC are gratefully acknowledged. The authors also acknowledge
the material suppliers Honeywell, Lafarge, US Silica, Elkem, and WR
Grace, for providing materials for this research. Permission to publish
was granted by the Director, Geotechnical and Structures Laboratory at
ERDC.
NR 46
TC 6
Z9 6
U1 8
U2 35
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0008-8846
EI 1873-3948
J9 CEMENT CONCRETE RES
JI Cem. Concr. Res.
PD FEB
PY 2015
VL 68
BP 94
EP 104
DI 10.1016/j.cemconres.2014.11.005
PG 11
WC Construction & Building Technology; Materials Science, Multidisciplinary
SC Construction & Building Technology; Materials Science
GA CB4BE
UT WOS:000349572400009
ER
PT J
AU Ouedraogo, AL
Bastiaens, GJH
Tiono, AB
Guelbeogo, WM
Kobylinski, KC
Ouedraogo, A
Barry, A
Bougouma, EC
Nebie, I
San Ouattara, M
Lanke, KHW
Fleckenstein, L
Sauerwein, RW
Slater, HC
Churcher, TS
Sirima, SB
Drakeley, C
Bousema, T
AF Ouedraogo, Andre Lin
Bastiaens, Guido J. H.
Tiono, Alfred B.
Guelbeogo, Wamdaogo M.
Kobylinski, Kevin C.
Ouedraogo, Alphonse
Barry, Aissata
Bougouma, Edith C.
Nebie, Issa
San Ouattara, Maurice
Lanke, Kjerstin H. W.
Fleckenstein, Lawrence
Sauerwein, Robert W.
Slater, Hannah C.
Churcher, Thomas S.
Sirima, Sodiomon B.
Drakeley, Chris
Bousema, Teun
TI Efficacy and Safety of the Mosquitocidal Drug Ivermectin to Prevent
Malaria Transmission After Treatment: A Double-Blind, Randomized,
Clinical Trial
SO CLINICAL INFECTIOUS DISEASES
LA English
DT Article
DE falciparum; gametocyte; transmission; survivorship; sporogony
ID PLASMODIUM-FALCIPARUM MALARIA; ARTEMETHER-LUMEFANTRINE; MASS TREATMENT;
ONCHOCERCIASIS; PRIMAQUINE; CHILDREN; PLASMA; ASSAY
AB Background. Artemisinin combination therapy effectively clears asexual malaria parasites and immature gametocytes but does not prevent posttreatment malaria transmission. Ivermectin (IVM) may reduce malaria transmission by killing mosquitoes that take blood meals from IVM-treated humans.
Methods. In this double-blind, placebo-controlled trial, 120 asymptomatic Plasmodium falciparum parasite carriers were randomized to receive artemether-lumefantrine (AL) plus placebo or AL plus a single or repeated dose (200 mu g/kg) of ivermectin (AL-IVM1 and AL-IVM2, respectively). Mosquito membrane feeding was performed 1, 3, and 7 days after initiation of treatment to determine Anopheles gambiae and Anopheles funestus survival and infection rates.
Results. The AL-IVM combination was well tolerated. IVM resulted in a 4- to 7-fold increased mortality in mosquitoes feeding 1 day after IVM(P < .001). Day 7 IVM plasma levels were positively associated with body mass index (r = 0.57, P < .001) and were higher in female participants (P = .003), for whom An. gambiae mosquito mortality was increased until 7 days after a single dose of IVM (hazard rate ratio, 1.34 [95% confidence interval, 1.07-1.69]; P = .012). Although we found no evidence that IVM reduced Plasmodium infection rates among surviving mosquitoes, the mosquitocidal effect of AL-IVM1 and AL-IVM2 resulted in 27% and 35% reductions, respectively, in estimated malaria transmission potential during the first week after initiation of treatment.
Conclusions. We conclude that IVM can be safely given in combination with AL and can reduce the likelihood of malaria transmission by reducing the life span of feeding mosquitoes.
C1 [Ouedraogo, Andre Lin; Tiono, Alfred B.; Guelbeogo, Wamdaogo M.; Ouedraogo, Alphonse; Barry, Aissata; Bougouma, Edith C.; Nebie, Issa; San Ouattara, Maurice; Sirima, Sodiomon B.] Ctr Natl Rech & Format Paludisme, Dept Biomed Sci, Ouagadougou, Burkina Faso.
[Bastiaens, Guido J. H.; Lanke, Kjerstin H. W.; Sauerwein, Robert W.; Bousema, Teun] Radboud Univ Nijmegen Med Ctr, Dept Med Microbiol, NL-6500 HB Nijmegen, Netherlands.
[Kobylinski, Kevin C.] Walter Reed Army Inst Res, Entomol Branch, Silver Spring, MD USA.
[Kobylinski, Kevin C.] Armed Forces Res Inst Med Sci, Entomol Dept, Bangkok 10400, Thailand.
[Fleckenstein, Lawrence] Univ Iowa, Coll Pharm, Iowa City, IA 52242 USA.
[Slater, Hannah C.; Churcher, Thomas S.] Univ London Imperial Coll Sci Technol & Med, MRC Ctr Outbreak Anal & Modelling, London SW7 2AZ, England.
[Drakeley, Chris; Bousema, Teun] London Sch Hyg & Trop Med, Dept Immunol & Infect, London, England.
RP Bousema, T (reprint author), Radboud Univ Nijmegen Med Ctr, Dept Med Microbiol, Geert Grootepl Zuid 26-28, NL-6500 HB Nijmegen, Netherlands.
EM teun.bousema@radboudumc.nl
RI Sauerwein, Robert/C-8519-2013; Bousema, Teun/N-3574-2014; Bastiaens,
Guido/P-6642-2015;
OI Slater, Hannah/0000-0003-4291-7899; Churcher, Thomas/0000-0002-8442-0525
FU Bill & Melinda Gates Foundation [OPP1034789]; Radboud University Medical
Center
FX This work was supported by the Bill & Melinda Gates Foundation (grant
number OPP1034789) and by the Radboud University Medical Center (Radboud
Hypatia Track). Novartis provided the artemether-lumefantrine.
NR 27
TC 13
Z9 13
U1 3
U2 7
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 1058-4838
EI 1537-6591
J9 CLIN INFECT DIS
JI Clin. Infect. Dis.
PD FEB 1
PY 2015
VL 60
IS 3
BP 357
EP 365
DI 10.1093/cid/ciu797
PG 9
WC Immunology; Infectious Diseases; Microbiology
SC Immunology; Infectious Diseases; Microbiology
GA CB6UG
UT WOS:000349761600013
PM 25414262
ER
PT J
AU Casali, JG
Robinette, MB
AF Casali, John G.
Robinette, Martin B.
TI Effects of user training with electronically-modulated sound
transmission hearing protectors and the open ear on horizontal
localization ability
SO INTERNATIONAL JOURNAL OF AUDIOLOGY
LA English
DT Article
DE Auditory learning; sensory adaptation; localization; hearing protection;
electronically modulated; warfighter; interaural level differences;
interaural time differences; TCAPS; active HPDs
ID ADAPTATION; COORDINATION; FIELD
AB Objective: To determine if training with electronically-modulated hearing protection (EMHP) and the open ear results in auditory learning on a horizontal localization task. Design: Baseline localization testing was conducted in three listening conditions (open-ear, in-the-ear (ITE) EMHP, and over-the-ear (OTE) EMHP). Participants then wore either an ITE or OTE EMHP for 12, almost daily, one-hour training sessions. After training was complete, participants again underwent localization testing in all three listening conditions. A computer with a custom software and hardware interface presented localization sounds and collected participant responses. Study sample: Twelve participants were recruited from the student population at Virginia Tech. Audiometric requirements were 35 dBHL at 500, 1000, and 2000 Hz bilaterally, and 55 dBHL at 4000 Hz in at least one ear. Results: Pre-training localization performance with an ITE or OTE EMHP was worse than open-ear performance. After training with any given listening condition, including open-ear, performance in that listening condition improved, in part from a practice effect. However, post-training localization performance showed near equal performance between the open-ear and training EMHP. Auditory learning occurred for the training EMHP, but not for the non-training EMHP; that is, there was no significant training crossover effect between the ITE and the OTE devices. Conclusion: It is evident from this study that auditory learning (improved horizontal localization performance) occurred with the EMHP for which training was performed. However, performance improvements found with the training EMHP were not realized in the non-training EMHP. Furthermore, localization performance in the open-ear condition also benefitted from training on the task.
C1 [Casali, John G.] Virginia Polytech Inst & State Univ, Auditory Syst Lab, Virginia Tech, Blacksburg, VA 24061 USA.
[Robinette, Martin B.] US Army Publ Hlth Command, Aberdeen Proving Ground, MD USA.
RP Casali, JG (reprint author), Virginia Tech, Auditory Syst Lab, 250 Durham Hall, Blacksburg, VA 24061 USA.
EM jcasali@exchange.vt.edu
FU Office of Naval Research
FX The authors are grateful for the funding provided by the Office of Naval
Research, Kurt Yankaskas, Contract Technical Officer, and to Doug
Brungart of Walter Reed National Military Medical Center, for technical
assistance.
NR 21
TC 2
Z9 2
U1 0
U2 1
PU INFORMA HEALTHCARE
PI LONDON
PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND
SN 1499-2027
EI 1708-8186
J9 INT J AUDIOL
JI Int. J. Audiol.
PD FEB
PY 2015
VL 54
SU 1
BP S37
EP S45
DI 10.3109/14992027.2014.973538
PG 9
WC Audiology & Speech-Language Pathology; Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Otorhinolaryngology
GA CB5MF
UT WOS:000349670800006
PM 25549166
ER
PT J
AU Fresconi, F
Rogers, J
AF Fresconi, Frank
Rogers, Jonathan
TI Flight Control of a Small-Diameter Spin-Stabilized Projectile Using
Imager Feedback
SO JOURNAL OF GUIDANCE CONTROL AND DYNAMICS
LA English
DT Article
ID ORIENTATION ESTIMATOR; GUIDANCE; MISSILE; SENSORS
AB Small-diameter gun-launched projectiles pose a challenging platform on which to implement closed-loop guidance and control. This paper presents a novel imager-based guidance and control algorithm for small-diameter spin-stabilized projectiles. The control law is specifically formulated to rely on feedback only from a strapdown detector and roll angle sensors. Following introduction of the projectile nonlinear dynamic model, an integrated guidance and control algorithm is presented in which control commands are computed directly from detector feedback using a gain-scheduled proportional control. Time-varying controller gains are derived through a surrogate modeling approach, and controller performance is further enhanced through use of an observer that filters unwanted angular motion components from detector feedback. Example closed-loop flight simulations demonstrate performance of the proposed control system, and MonteCarlo analysis shows a factor of 2 accuracy improvement for the closed-loop system over ballistic flight. Results indicate that delivery system improvements are achievable in small, gyroscopically stabilized projectiles containing low-cost guidance elements using the proposed integrated guidance and control approach.
C1 S Army Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA.
Georgia Inst Technol, Sch Mech Engn, Atlanta, GA 30332 USA.
[Fresconi, Frank] US Army Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA.
[Rogers, Jonathan] Georgia Inst Technol, Sch Mech Engn, Atlanta, GA 30332 USA.
RP Fresconi, F (reprint author), US Army Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA.
NR 34
TC 0
Z9 1
U1 3
U2 15
PU AMER INST AERONAUTICS ASTRONAUTICS
PI RESTON
PA 1801 ALEXANDER BELL DRIVE, STE 500, RESTON, VA 22091-4344 USA
SN 0731-5090
EI 1533-3884
J9 J GUID CONTROL DYNAM
JI J. Guid. Control Dyn.
PD FEB
PY 2015
VL 38
IS 2
BP 181
EP 191
DI 10.2514/1.G000815
PG 11
WC Engineering, Aerospace; Instruments & Instrumentation
SC Engineering; Instruments & Instrumentation
GA CB1DW
UT WOS:000349368000001
ER
PT J
AU Klett, H
Rodriguez-Fernandez, M
Dineen, S
Leon, LR
Timmer, J
Doyle, FJ
AF Klett, Hagen
Rodriguez-Fernandez, Maria
Dineen, Shauna
Leon, Lisa R.
Timmer, Jens
Doyle, Francis J., III
TI Modeling the inflammatory response in the hypothalamus ensuing heat
stroke: Iterative cycle of model calibration, identifiability analysis,
experimental design and data collection
SO MATHEMATICAL BIOSCIENCES
LA English
DT Article
DE Heat stroke; Hypothalamus; Mathematical modeling; Optimal experimental
design; Bayesian
ID TUMOR-NECROSIS-FACTOR; FACTOR-ALPHA; INTERLEUKIN-6; EXPRESSION; FEVER;
ACTIVATION; MECHANISMS; CYTOKINES; BIOLOGY; SYSTEMS
AB Heat Stroke (HS) is a life-threatening illness caused by prolonged exposure to heat that causes severe hyperthermia and nervous system abnormalities. The long term consequences of HS are poorly understood and deeper insight is required to find possible treatment strategies. Elevated pro- and anti-inflammatory cytokines during HS recovery suggest to play a major role in the immune response. In this study, we developed a mathematical model to understand the interactions and dynamics of cytokines in the hypothalamus, the main thermoregulatory center in the brain. Uncertainty and identifiability analysis of the calibrated model parameters revealed non-identifiable parameters due to the limited amount of data. To overcome the lack of identifiability of the parameters, an iterative cycle of optimal experimental design, data collection, re-calibration and model reduction was applied and further informative experiments were suggested. Additionally, a new method of approximating the prior distribution of the parameters for Bayesian optimal experimental design based on the profile likelihood is presented. (C) 2014 Elsevier Inc. All rights reserved.
C1 [Klett, Hagen; Rodriguez-Fernandez, Maria; Doyle, Francis J., III] Univ Calif Santa Barbara, Dept Chem Engn, Santa Barbara, CA 93106 USA.
[Dineen, Shauna; Leon, Lisa R.] US Army Res Inst Environm Med, Thermal & Mt Med Div, Natick, MA USA.
[Klett, Hagen; Timmer, Jens] Univ Freiburg, Inst Phys, D-79106 Freiburg, Germany.
[Timmer, Jens] Univ Freiburg, BIOSS Ctr Biol Signalling Studies, D-79106 Freiburg, Germany.
RP Rodriguez-Fernandez, M (reprint author), Univ Calif Santa Barbara, Dept Chem Engn, Santa Barbara, CA 93106 USA.
EM maria.rodriguez.fernan@gmail.com
RI Rodriguez-Fernandez, Maria/I-7193-2016
OI Rodriguez-Fernandez, Maria/0000-0003-1966-2920
FU U.S. Army Research Office [W911NF-09-0001]
FX This work was supported in part by the Institute for Collaborative
Biotechnologies through Grant W911NF-09-0001 from the U.S. Army Research
Office.
NR 39
TC 0
Z9 0
U1 0
U2 7
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0025-5564
EI 1879-3134
J9 MATH BIOSCI
JI Math. Biosci.
PD FEB
PY 2015
VL 260
SI SI
BP 35
EP 46
DI 10.1016/j.mbs.2014.07.011
PG 12
WC Biology; Mathematical & Computational Biology
SC Life Sciences & Biomedicine - Other Topics; Mathematical & Computational
Biology
GA CB4CF
UT WOS:000349575100007
PM 25119202
ER
PT J
AU Lacey, SD
Wan, JY
Cresce, AV
Russell, SM
Dai, JQ
Bao, WZ
Xu, K
Hu, LB
AF Lacey, Steven D.
Wan, Jiayu
Cresce, Arthur von Wald
Russell, Selena M.
Dai, Jiaqi
Bao, Wenzhong
Xu, Kang
Hu, Liangbing
TI Atomic Force Microscopy Studies on Molybdenum Disulfide Flakes as
Sodium-Ion Anodes
SO NANO LETTERS
LA English
DT Article
DE In situ AFM; MoS2; wrinkling; SEI; sodium-ion battery; microbattery
ID SOLID-ELECTROLYTE INTERPHASE; TRANSITION-METAL DICHALCOGENIDES; IN-SITU;
LITHIUM INTERCALATION; BATTERY APPLICATIONS; CARBON NANOFIBERS; MOS2
NANOSHEETS; INSERTION; PERFORMANCE; LIQUID
AB A microscale battery comprised of mechanically exfoliated molybdenum disulfide (MoS2) flakes with copper connections and a sodium metal reference was created and investigated as an intercalation model using in situ atomic force microscopy in a dry room environment. While an ethylene carbonate-based electrolyte with a low vapor pressure allowed topographical observations in an open cell configuration, the planar microbattery was used to conduct in situ measurements to understand the structural changes and the concomitant solid electrolyte interphase (SEI) formation at the nanoscale. Topographical observations demonstrated permanent wrinkling behavior of MoS2 electrodes upon sodiation at 0.4 V. SEI formation occurred quickly on both flake edges and planes at voltages before sodium intercalation. Force spectroscopy measurements provided quantitative data on the SEI thickness for MoS2 electrodes in sodium-ion batteries for the first time.
C1 [Lacey, Steven D.; Wan, Jiayu; Dai, Jiaqi; Bao, Wenzhong; Hu, Liangbing] Univ Maryland, Dept Mat Sci & Engn, College Pk, MD 20742 USA.
[Cresce, Arthur von Wald; Russell, Selena M.; Xu, Kang] US Army Res Lab, Electrochem Branch, Power & Energy Div, Sensor & Electron Devices Directorate, Adelphi, MD 20783 USA.
RP Hu, LB (reprint author), Univ Maryland, Dept Mat Sci & Engn, College Pk, MD 20742 USA.
EM binghu@umd.edu
RI Bao, Wenzhong/B-2453-2012; Hu, Liangbing/N-6660-2013
OI Bao, Wenzhong/0000-0002-3871-467X;
FU NSF [CBET-1335979/1335944]; Department of Energy Applied Battery
Research (DOE-ABR) Program; U.S. Army Research Laboratory
FX We acknowledge the support from NSF CBET-1335979/1335944. Partial
financial support from Department of Energy Applied Battery Research
(DOE-ABR) Program is appreciated. S.R. was supported by an appointment
to the U.S. Army Research Laboratory Postdoctoral Fellowship Program
administered by the Oak Ridge Associated Universities through a
cooperative agreement with the U.S. Army Research Laboratory.
NR 38
TC 28
Z9 28
U1 23
U2 217
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 1530-6984
EI 1530-6992
J9 NANO LETT
JI Nano Lett.
PD FEB
PY 2015
VL 15
IS 2
BP 1018
EP 1024
DI 10.1021/nl503871s
PG 7
WC Chemistry, Multidisciplinary; Chemistry, Physical; Nanoscience &
Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied;
Physics, Condensed Matter
SC Chemistry; Science & Technology - Other Topics; Materials Science;
Physics
GA CB4DI
UT WOS:000349578000033
PM 25549278
ER
PT J
AU Lien, DH
Kang, JS
Amani, M
Chen, K
Tosun, M
Wang, HP
Roy, T
Eggleston, MS
Wu, MC
Dubey, M
Lee, SC
He, JH
Javey, A
AF Lien, Der-Hsien
Kang, Jeong Seuk
Amani, Matin
Chen, Kevin
Tosun, Mahmut
Wang, Hsin-Ping
Roy, Tania
Eggleston, Michael S.
Wu, Ming C.
Dubey, Madan
Lee, Si-Chen
He, Jr-Hau
Javey, Ali
TI Engineering Light Outcoupling in 2D Materials
SO NANO LETTERS
LA English
DT Article
DE 2D materials; light outcoupling; substrate interference;
photoluminescence; Raman
ID RAMAN-SPECTROSCOPY; LAYER MOS2; GRAPHENE; WSE2; PHOTOLUMINESCENCE;
EMISSION; DIODES; ENERGY; FILMS
AB When light is incident on 2D transition metal dichalcogenides (TMDCs), it engages in multiple reflections within underlying substrates, producing interferences that lead to enhancement or attenuation of the incoming and outgoing strength of light. Here, we report a simple method to engineer the light outcoupling in semiconducting TMDCs by modulating their dielectric surroundings. We show that by modulating the thicknesses of underlying substrates and capping layers, the interference caused by substrate can significantly enhance the light absorption and emission of WSe2, resulting in a similar to 11 times increase in Raman signal and a similar to 30 times increase in the photoluminescence (PL) intensity of WSe2. On the basis of the interference model, we also propose a strategy to control the photonic and optoelectronic properties of thin-layer WSe2. This work demonstrates the utilization of outcoupling engineering in 2D materials and offers a new route toward the realization of novel optoelectronic devices, such as 2D LEDs and solar cells.
C1 [Lien, Der-Hsien; Kang, Jeong Seuk; Amani, Matin; Chen, Kevin; Tosun, Mahmut; Wang, Hsin-Ping; Roy, Tania; Eggleston, Michael S.; Wu, Ming C.; Javey, Ali] Univ Calif Berkeley, Berkeley, CA 94720 USA.
[Lien, Der-Hsien; Kang, Jeong Seuk; Amani, Matin; Chen, Kevin; Tosun, Mahmut; Wang, Hsin-Ping; Roy, Tania; Javey, Ali] Univ Calif Berkeley, Lawrence Berkeley Natl Lab, Div Mat Sci, Berkeley, CA 94720 USA.
[Lien, Der-Hsien; Wang, Hsin-Ping; He, Jr-Hau] KAUST, Comp Elect & Math Sci & Engn CEMSE Div, Thuwal 239556900, Saudi Arabia.
[Lien, Der-Hsien; Wang, Hsin-Ping; Lee, Si-Chen] Natl Taiwan Univ, Inst Elect Engn, Dept Elect Engn, Taipei 10617, Taiwan.
[Dubey, Madan] US Army Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA.
RP He, JH (reprint author), KAUST, Comp Elect & Math Sci & Engn CEMSE Div, Thuwal 239556900, Saudi Arabia.
EM jrhau.he@kaust.edu.sa; ajavey@eecs.berkeley.edu
RI He, Jr-Hau/B-5141-2011; Javey, Ali/B-4818-2013
OI He, Jr-Hau/0000-0003-1886-9241;
NR 27
TC 25
Z9 25
U1 6
U2 85
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 1530-6984
EI 1530-6992
J9 NANO LETT
JI Nano Lett.
PD FEB
PY 2015
VL 15
IS 2
BP 1356
EP 1361
DI 10.1021/nl504632u
PG 6
WC Chemistry, Multidisciplinary; Chemistry, Physical; Nanoscience &
Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied;
Physics, Condensed Matter
SC Chemistry; Science & Technology - Other Topics; Materials Science;
Physics
GA CB4DI
UT WOS:000349578000085
PM 25602462
ER
PT J
AU Karl, JP
Thompson, LA
Niro, PJ
Margolis, LM
McClung, JP
Cao, JJ
Whigham, LD
Combs, GF
Young, AJ
Lieberman, HR
Pasiakos, SM
AF Karl, J. Philip
Thompson, Lauren A.
Niro, Philip J.
Margolis, Lee M.
McClung, James P.
Cao, Jay J.
Whigham, Leah D.
Combs, Gerald F., Jr.
Young, Andrew J.
Lieberman, Harris R.
Pasiakos, Stefan M.
TI Transient decrements in mood during energy deficit are independent of
dietary protein-to-carbohydrate ratio
SO PHYSIOLOGY & BEHAVIOR
LA English
DT Article
DE Macronutrient composition; Neurotransmitter precursor; Weight loss;
Cognition; Sleep; Recommended dietary allowance
ID SUBJECTIVE SLEEP QUALITY; WEIGHT-LOSS; COGNITIVE PERFORMANCE; OBESE
WOMEN; BRAIN; TRIAL; RESTRICTION; MAINTENANCE; OVERWEIGHT; PRECURSOR
AB Energy deficit and dietary macronutrient intake are thought to independently modulate cognition, mood and sleep. To what extent manipulating the dietary ratio of protein-to-carbohydrate affects mood, cognition and sleep during short-term energy deficit is undetermined. Using a randomized, block design, 39 non-obese young adults (21 +/- 1 years, BMI 25 +/- 1 kg/m(2)) consumed diets containing 0.8 g, 1.6 g or 2.4 g protein per kg body weight per day for 31 days. Carbohydrate intake was reduced to accommodate higher protein intakes while dietary fat was maintained at 30% of total energy intake. Cognitive performance, mood, self-reported sleep quality, and plasma amino add concentrations were periodically assessed during a 10-day energy balance period and a subsequent 21 -day, 40% energy deficit period. Anger, tension and total mood disturbance increased during the initial ten days of energy deficit (P < 0.05), but by the end of the energy deficit returned to levels not different from those measured during energy balance. No effects of dietary protein-to-carbohydrate ratio on cognitive performance, mood or self-reported sleep quality were observed during energy balance or energy deficit. Thus, high-protein, low-carbohydrate, moderate-fat diets do not appear to benefit or impair cognition, mood or sleep in non-obese adults during energy deficit. These findings suggest that energy deficit may initially be psychologically difficult for non-obese individuals attempting to lose weight, but that these changes are transient. Employing strategies that alleviate decrements in mood during this initial period of adaptation may help sustain weight loss efforts. Published by Elsevier Inc.
C1 [Karl, J. Philip; Thompson, Lauren A.; Niro, Philip J.; Margolis, Lee M.; McClung, James P.; Young, Andrew J.; Lieberman, Harris R.; Pasiakos, Stefan M.] US Army, Mil Nutr Div, Environm Med Res Inst, Natick, MA 01760 USA.
[Cao, Jay J.; Combs, Gerald F., Jr.] ARS, Grand Forks Human Nutr Res Ctr, USDA, Grand Forks, ND 58203 USA.
[Whigham, Leah D.] Paso del Norte Inst Hlth Living, El Paso, TX 79968 USA.
RP Pasiakos, SM (reprint author), US Army, Environm Med Res Inst, 15 Kansas St,Bldg 42, Natick, MA 01760 USA.
EM james.p.karl@us.army.mil; lauren.a.thompson@us.army.mil;
philip.niro@us.army.mil; lee.m.margolis.ctr@mail.mil;
james.p.mcclung8.civ@mail.mil; jay.cao@ars.usda.gov; ldwhigham@utep.edu;
gerald.combs@ars.usda.gov; andrew.j.young.civ@mail.mil;
harris.lieberman@us.army.mil; stefan.pasiakos@us.army.mil
RI Pasiakos, Stefan/E-6295-2014; Biguzzi, Felipe/E-4724-2015;
OI Pasiakos, Stefan/0000-0002-5378-5820; Karl, J.
Philip/0000-0002-5871-2241; , Lee/0000-0002-0652-1304; Whigham,
Leah/0000-0002-5376-8967
FU U.S. Army Medical Research and Material Command; U.S. Department of
Agriculture, Agricultural Research Service [58-1950-7-707]
FX The U.S. Army Medical Research and Material Command and the U.S.
Department of Agriculture, Agricultural Research Service, under
agreement No. 58-1950-7-707.
NR 44
TC 1
Z9 1
U1 4
U2 14
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0031-9384
J9 PHYSIOL BEHAV
JI Physiol. Behav.
PD FEB
PY 2015
VL 139
BP 524
EP 531
DI 10.1016/j.physbeh.2014.11.068
PG 8
WC Psychology, Biological; Behavioral Sciences
SC Psychology; Behavioral Sciences
GA CB4BY
UT WOS:000349574400072
PM 25479571
ER
PT J
AU Edillo, FE
Halasa, YA
Largo, FM
Erasmo, JNV
Amoin, NB
Alera, MTP
Yoon, IK
Alcantara, AC
Shepard, DS
AF Edillo, Frances E.
Halasa, Yara A.
Largo, Francisco M.
Erasmo, Jonathan Neil V.
Amoin, Naomi B.
Alera, Maria Theresa P.
Yoon, In-Kyu
Alcantara, Arturo C.
Shepard, Donald S.
TI Economic Cost and Burden of Dengue in the Philippines
SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
LA English
DT Article
ID SOUTHEAST-ASIA; DISEASE BURDEN; CHILDREN; AMERICA; ILLNESS; VIRUSES
AB Dengue, the world's most important mosquito-borne viral disease, is endemic in the Philippines. During 2008-2012, the country's Department of Health reported an annual average of 117,065 dengue cases, placing the country fourth in dengue burden in southeast Asia. This study estimates the country's annual number of dengue episodes and their economic cost. Our comparison of cases between active and passive surveillance in Punta Princesa, Cebu City yielded an expansion factor of 7.2, close to the predicted value (7.0) based on the country's health system. We estimated an annual average of 842,867 clinically diagnosed dengue cases, with direct medical costs (in 2012 US dollars) of $345 million ($3.26 per capita). This is 54% higher than an earlier estimate without Philippines-specific costs. Ambulatory settings treated 35% of cases (representing 10% of direct costs), whereas inpatient hospitals served 65% of cases (representing 90% of direct costs). The economic burden of dengue in the Philippines is substantial.
C1 [Edillo, Frances E.; Amoin, Naomi B.] Univ San Carlos, Dept Biol, Cebu, Philippines.
Brandeis Univ, Waltham, MA 02454 USA.
[Largo, Francisco M.] Univ San Carlos, Dept Econ, Cebu, Philippines.
Dept Hlth Reg 7, Cebu, Philippines.
[Alera, Maria Theresa P.] Philippine Armed Forces Res Inst Med Sci, Virol Res Unit, Cebu, Philippines.
[Yoon, In-Kyu] Armed Forces Res Inst Med Sci, Dept Virol, Bangkok 10400, Thailand.
[Alcantara, Arturo C.] Philippine Hlth Insurance Corp, Manila, Philippines.
RP Shepard, DS (reprint author), Brandeis Univ, Schneider Inst Hlth Policy, Heller Sch, MS 035, Waltham, MA 02454 USA.
EM feedillo@usc.edu.ph; yara@brandeis.edu; fmlargo@gmail.com;
jneilverasmo@yahoo.com; naomiamoin@yahoo.com;
mariatheresa.alera@afrims.org; yooni@afrims.org;
art.alcantara@gmail.com; shepard@brandeis.edu
FU Sanofi Pasteur, Inc.; Armed Forces Health Surveillance Center-Global
Emerging Infections Surveillance and Response System
FX This work was funded by a research agreement from Sanofi Pasteur, Inc.
to Brandeis University. The Punta Princesa cohort study was funded by
the Armed Forces Health Surveillance Center-Global Emerging Infections
Surveillance and Response System.
NR 39
TC 10
Z9 10
U1 0
U2 2
PU AMER SOC TROP MED & HYGIENE
PI MCLEAN
PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA
SN 0002-9637
EI 1476-1645
J9 AM J TROP MED HYG
JI Am. J. Trop. Med. Hyg.
PD FEB
PY 2015
VL 92
IS 2
BP 360
EP 366
DI 10.4269/ajtmh.14-0139
PG 7
WC Public, Environmental & Occupational Health; Tropical Medicine
SC Public, Environmental & Occupational Health; Tropical Medicine
GA CA6ZC
UT WOS:000349065400032
PM 25510723
ER
PT J
AU Filone, CM
Dower, K
Cowley, GS
Hensley, LE
Connor, JH
AF Filone, Claire Marie
Dower, Ken
Cowley, Glenn S.
Hensley, Lisa E.
Connor, John H.
TI Probing the Virus Host Interaction in High Containment: An Approach
Using Pooled Short Hairpin RNA
SO ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES
LA English
DT Article
ID NIEMANN-PICK C1; HIGH-THROUGHPUT; VACCINIA VIRUS; EBOLA VIRUSES; CORE
PROTEIN; IN-VITRO; CELLS; IDENTIFICATION; SCREEN; GENE
AB The study of viruses in high containment offers unique challenges for technology-intense approaches. These approaches include high-throughput screening for small-molecule antivirals and genetic perturbation-based screens for host factors required for viral replication. Here, we describe the use of whole-genome scale pooled short hairpin RNA (shRNA) libraries to screen for host factors necessary for viral infection at BSL2, and the transition of this technique into the BSL4 environment. Pooled screening provides a unique way to circumvent many of the technological challenges associated with other high-throughput screening approaches in high containment. Our pooled screening approach identified host factors involved in the replication of orthopoxviruses (Vaccinia and Monkeypox) and filoviruses (Ebola and Marburg) under conditions that enable straightforward screen-to-follow-up approaches.
C1 [Filone, Claire Marie; Dower, Ken; Connor, John H.] Boston Univ, Sch Med, Natl Emerging Infect Dis Lab, Boston, MA 02118 USA.
[Cowley, Glenn S.] Broad Inst, Cambridge, MA USA.
[Hensley, Lisa E.] US Army Med Res Inst Infect Dis, Ft Detrick, MD USA.
RP Connor, JH (reprint author), Boston Univ, Sch Med, Natl Emerging Infect Dis Lab, 620 Albany St, Boston, MA 02118 USA.
EM jhconnor@bu.edu
OI Connor, John/0000-0002-8867-7256
FU Postgraduate Research Participation Program; U.S. Army Research and
Medical Command [5T32AI089673-04]; SPARC grant from the Broad Institute;
[R03 MH094169]
FX The authors would like to thank the Boston University Flow Cytometry
Core Facility, especially Anna Belkina, for assistance with the cell
sorting experiment analysis. They would also like to acknowledge the
cell sorting staff at the MIT Koch Institute for sorting the VACV
screen. They would like to thank Monica Ogg and Kenny Lin for training
and assistance in high containment. C.M.F. was supported by the
Postgraduate Research Participation Program and the U.S. Army Research
and Medical Command administered by the Oak Ridge Institute for Science
and Education (ORISE) and training grant 5T32AI089673-04. This work was
also supported by a SPARC grant from the Broad Institute and in part by
R03 MH094169 to J.H.C.
NR 42
TC 0
Z9 0
U1 0
U2 1
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1540-658X
EI 1557-8127
J9 ASSAY DRUG DEV TECHN
JI ASSAY DRUG DEV. TECHNOL.
PD FEB 1
PY 2015
VL 13
IS 1
BP 34
EP 43
DI 10.1089/adt.2014.613
PG 10
WC Biochemical Research Methods; Pharmacology & Pharmacy
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy
GA CB7RL
UT WOS:000349824900005
PM 25646658
ER
PT J
AU Azimi, N
Xue, Z
Hua, LB
Takoudis, C
Zhang, SS
Zhang, ZC
AF Azimi, Nasim
Xue, Zheng
Hua, Libo
Takoudis, Christos
Zhang, Shengshui
Zhang, Zhengcheng
TI Additive Effect on the Electrochemical Performance of Lithium-Sulfur
Battery
SO ELECTROCHIMICA ACTA
LA English
DT Article
DE Electrolyte; LiDFOB additive; Silicon-based electrolyte; Coulombic
efficiency; Lithium-sulfur batteries
ID LI-S BATTERIES; DISCHARGE PERFORMANCE; LIQUID ELECTROLYTE; GRAPHENE
OXIDE; COMPOSITE; CELL; CATHODE; CHARGE
AB Lithium difluoro(oxalato) borate (LiDFOB) was investigated as an electrolyte additive for the Li-S battery. This additive was identified to be an efficient electrolyte additive to suppress the polysulfide shuttling effect existing in the conventional Li-S chemistry. To detect the positive impact of the new additive, oligo (ethylene glycol) functionalized silane was employed as the electrolyte solvent due to its high solvation capability with the lithium polysulfides. The electrochemical results and the SEM data of Li-S battery using the new electrolyte confirmed the role of the LiDFOB as a critical component to eliminate the shuttling of the dissolved polysulfides thus enabling a high coulombic efficiency. (C) 2014 Elsevier Ltd. All rights reserved.
C1 [Azimi, Nasim; Xue, Zheng; Hua, Libo; Zhang, Zhengcheng] Argonne Natl Lab, Chem Sci & Engn Div, Argonne, IL 60439 USA.
[Azimi, Nasim; Takoudis, Christos] Univ Illinois, Dept Chem Engn, Chicago, IL 60607 USA.
[Azimi, Nasim; Takoudis, Christos] Univ Illinois, Dept Bioengn, Chicago, IL 60607 USA.
[Zhang, Shengshui] US Army Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA.
RP Zhang, ZC (reprint author), Argonne Natl Lab, Chem Sci & Engn Div, 9700 S Cass Ave, Argonne, IL 60439 USA.
EM zzhang@anl.gov
RI Zhang, Sheng/A-4456-2012
OI Zhang, Sheng/0000-0003-4435-4110
FU Vehicle Technologies Office, U.S. Department of Energy; UChicago
Argonne, LLC [DE-AC02-06CH11357]
FX This research is supported by the Vehicle Technologies Office, U.S.
Department of Energy. Argonne, a U.S. Department of Energy laboratory,
is operated by UChicago Argonne, LLC under contract DE-AC02-06CH11357.
Z.Z. would like to thank Prof. Donghai Wang from Pennsylvania State
University for the technical discussions.
NR 35
TC 8
Z9 8
U1 14
U2 97
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0013-4686
EI 1873-3859
J9 ELECTROCHIM ACTA
JI Electrochim. Acta
PD FEB 1
PY 2015
VL 154
BP 205
EP 210
DI 10.1016/j.electacta.2014.12.041
PG 6
WC Electrochemistry
SC Electrochemistry
GA CB3RR
UT WOS:000349546500027
ER
PT J
AU Frankenstein, S
Stevens, M
Scott, C
AF Frankenstein, Susan
Stevens, Maria
Scott, Constance
TI Ingestion of Simulated SMAP L3 Soil Moisture Data into Military Maneuver
Planning
SO JOURNAL OF HYDROMETEOROLOGY
LA English
DT Article
ID CONE INDEX; LAND; ASSIMILATION
AB This paper uses simulated SMAP level-3 (L3) soil moisture data to calculate soil strength directly and compares the results against the current Noah Land Information System-based climatology approach. Based on the availability of data, three sites were chosen for the study: Cheorwon, South Korea; Laboue, Lebanon; and Asham, Nigeria. The simulated SMAP satellite data are representative of May conditions. For all three regions, this is best represented by the "average" soil moisture used in the current climatology approach. The cumulative distribution frequency of the two soil moisture sources indicates good agreement at Asham, Nigeria; mixed agreement at Cheorwon, South Korea; and no agreement at Laboue, Lebanon. Soil strengths and resulting vehicle speeds for a High Mobility Multipurpose Wheeled Vehicle (HMMWV) M1097 were calculated based on the Harmonized World Soil Database soil types used by the two soil moisture sources, as well as with a finer-resolution National Geospatial-Intelligence Agency product. Better agreement was found in soil strengths using the finer-resolution soil product. Finally, fairly large differences in soil moisture become muted in the speed calculations even when all factors except soil strength, slope, and vehicle performance are neglected. It is expected that the 0.04 volumetric uncertainty in the final SMAP L3 soil moisture product will have the greatest effect at low vehicle speeds. Field measurements of soil moisture and strength as well as soil type are needed to verify the results.
C1 [Frankenstein, Susan; Scott, Constance] US Army Corps Engineers, Engn Res & Dev Ctr, Cold Regions Res & Engn Lab, Hanover, NH USA.
[Stevens, Maria] US Army Corps Engineers, Engn Res & Dev Ctr, Geotechn & Struct Lab, Vicksburg, MS USA.
RP Frankenstein, S (reprint author), Erdc, CRREL, 72 Lyme Rd, Hanover, NH 03755 USA.
EM susan.frankenstein@usace.army.mil
FU Army 6.2 applied research program GeoEnabled Multi-Modal Situation
Awareness-Targets and Terrain Simulation (GEMS-T2S)
FX This study was funded by the Army 6.2 applied research program
GeoEnabled Multi-Modal Situation Awareness-Targets and Terrain
Simulation (GEMS-T2S). Recognition also goes to the SMAP Early Adopter
Program.
NR 37
TC 1
Z9 1
U1 1
U2 9
PU AMER METEOROLOGICAL SOC
PI BOSTON
PA 45 BEACON ST, BOSTON, MA 02108-3693 USA
SN 1525-755X
EI 1525-7541
J9 J HYDROMETEOROL
JI J. Hydrometeorol.
PD FEB
PY 2015
VL 16
IS 1
BP 427
EP 440
DI 10.1175/JHM-D-14-0032.1
PG 14
WC Meteorology & Atmospheric Sciences
SC Meteorology & Atmospheric Sciences
GA CB1DR
UT WOS:000349367500028
ER
PT J
AU Taheri, S
Sandu, C
Taheri, S
Pinto, E
Gorsich, D
AF Taheri, Sh.
Sandu, C.
Taheri, S.
Pinto, E.
Gorsich, D.
TI A technical survey on Terramechanics models for tire-terrain interaction
used in modeling and simulation of wheeled vehicles
SO JOURNAL OF TERRAMECHANICS
LA English
DT Review
DE Wheeled vehicle; Terramechanics; Off-road; Deformable terrain; Tire
model; Soil; Parameterization; Mobility
ID DISTINCT ELEMENT METHOD; TYRE-SOIL INTERACTION; SOFT SOIL; CONTACT;
DYNAMICS; MOBILITY; PERFORMANCES; COMPACTION; RESISTANCE
AB Accurate and efficient tire models for deformable terrain operations are essential for performing vehicle simulations. A direct application of an on-road tire model to simulate tire behavior on a deformable terrain such as soft soil is not possible. The methods for modeling and evaluation of performance of the wheeled vehicles on deformable terrains are influenced by different terrain properties in addition to design and operational parameters. These methods are ranged from very simple empirical methods to highly complex finite element methods. This survey covers the most used models that have been developed for wheeled vehicles in off-road applications. The emphasize is on the models that have made a significant contribution in advancement of techniques for characterizing soil, tire, soil tire interaction, experimental analysis, model parameterization and model validation. A description is given for selected studies to familiarize the reader with the general terminologies, formulations and modeling approaches. More importantly, two summary tables are given for three groups of models in which the overall features of each model are reviewed and compared to other models. These tables can be used to understand the general picture of the available techniques, and facilitate selecting the appropriate model for future applications. (C) 2014 ISTVS. Published by Elsevier Ltd. All rights reserved.
C1 [Taheri, Sh.; Sandu, C.; Taheri, S.; Pinto, E.] Virginia Tech, Dept Mech Engn, Blacksburg, VA 24061 USA.
[Gorsich, D.] US Army, TARDEC, Warren, MI USA.
RP Taheri, S (reprint author), Virginia Tech, Dept Mech Engn, Blacksburg, VA 24061 USA.
EM taheri@vt.edu
FU Automotive Research Center (ARC), a U.S. Army Center of Excellence
FX This work has been partially funded by the Automotive Research Center
(ARC), a U.S. Army Center of Excellence for Modeling and Simulation of
Ground Vehicles.
NR 113
TC 10
Z9 13
U1 7
U2 27
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0022-4898
EI 1879-1204
J9 J TERRAMECHANICS
JI J. Terramech.
PD FEB
PY 2015
VL 57
BP 1
EP 22
DI 10.1016/j.jterra.2014.08.003
PG 22
WC Engineering, Environmental
SC Engineering
GA CB1ZK
UT WOS:000349426300001
ER
PT J
AU Braun, L
Sawyer, T
Smith, K
Hsu, A
Behrens, M
Chan, D
Hutchinson, J
Lu, D
Singh, R
Reyes, J
Lopreiato, J
AF Braun, LoRanee
Sawyer, Taylor
Smith, Kathleen
Hsu, Angela
Behrens, Melinda
Chan, Debora
Hutchinson, Jeffrey
Lu, Downing
Singh, Raman
Reyes, Joel
Lopreiato, Joseph
TI Retention of Pediatric Resuscitation Performance After a
Simulation-Based Mastery Learning Session: A Multicenter Randomized
Trial
SO PEDIATRIC CRITICAL CARE MEDICINE
LA English
DT Article
DE degradation; master learning; resuscitation; retention; simulation
ID ADVANCED LIFE-SUPPORT; INTENSIVE-CARE-UNIT; DELIBERATE PRACTICE; PATIENT
OUTCOMES; RESIDENTS; SKILLS; EDUCATION
AB Objectives: Using simulation-based mastery learning, residents can be trained to achieve a predefined performance standard in resuscitation. After mastery is achieved, performance degradation occurs over time. Prior investigations have shown performance retention of 12-14 months following intensive simulation-based mastery learning sessions. We sought to investigate the duration of mastery-level resuscitation performance retention after a single 1- to 2-hour simulation-based mastery learning session.
Design: Randomized, prospective trial.
Setting: Medical simulation laboratory.
Subjects: Convenience sample of 42 pediatric residents.
Interventions: Baseline resuscitation performance was determined on four standardized simulation scenarios. After determination of baseline performance, each resident repeated each scenario, as needed, until mastery-level performance was achieved. Residents were then randomized and retested 2, 4, or 6 months later. Statistical analysis on scores at baseline and retesting were used to determine performances changes from baseline and performance retention over time.
Measurements and Main Results: Forty-two residents participated in the study (12 in 2 mo group, 14 in 4 mo group, and 16 in 6 mo group). At baseline, postgraduate year-3 residents performed better than postgraduate year-1 residents (p = 0.003). Overall performance on each of the four scenarios improved at retesting. The percent of residents maintaining mastery-level performance showed a significant linear decline (p = 0.039), with a drop at each retesting interval; 92% retained mastery at 2 months, 71% at 4 months, and 56% at 6 months. There was no difference in retention between postgraduate year-1, postgraduate year-2, and postgraduate year-3 residents (p = 0.14).
Conclusions: Residents displayed significant improvements in resuscitation performance after a single simulation-based mastery learning session, but performance declined over time, with less than 60% retaining mastery-level performance at 6 months. Our results suggest that relatively frequent refresher training is needed after a single simulation-based mastery learning session. Additional research is needed to determine the duration of performance retention following any specific simulation-based mastery learning intervention.
C1 [Braun, LoRanee; Smith, Kathleen; Behrens, Melinda] Madigan Army Med Ctr, Tacoma, WA 98431 USA.
[Sawyer, Taylor; Hsu, Angela; Chan, Debora] Tripler Army Med Ctr, Honolulu, HI 96859 USA.
[Hutchinson, Jeffrey; Lu, Downing; Lopreiato, Joseph] Walter Reed Natl Mil Med Ctr, Bethesda, MD USA.
[Singh, Raman; Reyes, Joel] San Antonio Uniformed Serv Hlth Educ Consortium, San Antonio, TX USA.
RP Braun, L (reprint author), Madigan Army Med Ctr, Tacoma, WA 98431 USA.
EM loranee.e.braun.mil@mail.mil
NR 21
TC 3
Z9 3
U1 0
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1529-7535
EI 1947-3893
J9 PEDIATR CRIT CARE ME
JI Pediatr. Crit. Care Med.
PD FEB
PY 2015
VL 16
IS 2
BP 131
EP 138
DI 10.1097/PCC.0000000000000315
PG 8
WC Critical Care Medicine; Pediatrics
SC General & Internal Medicine; Pediatrics
GA CB1KZ
UT WOS:000349387600011
PM 25647122
ER
PT J
AU Soonwera, M
Phasornkusolsill, S
AF Soonwera, Mayura
Phasornkusolsill, Siriporn
TI Efficacy of Thai herbal essential oils as green repellent against
mosquito vectors
SO ACTA TROPICA
LA English
DT Article
DE Repellency; Cananga odorata oil; Cymbopogon citratus oil; Aedes aegypti;
Culex quinquefasciatus
ID AEDES
AB Repellency activity of Thai essential oils derived from ylang ylang (Cananga odorata (Lamk.) Hook.f. & Thomson: Annonaceae) and lemongrass (Cymbopogon citratus (DC.) Stapf: Poaceae) were tested against two mosquito vectors, Aedes aegypti (L.) and Culex quinquefasciatus (Say). There were compared with two chemical repellents (DEET 20% w/w; Sketolene Shield(R) and IR3535, ethyl butylacetylaminopropionate 12.5% w/w; Johnson's Baby Clear Lotion Anti-Mosquito(R)). Each herbal repellent was applied in three diluents; coconut oil, soybean oil and olive oil at 0.33 mu l/cm(2) on the forearm of volunteers. All herbal repellent exhibited higher repellent activity than IR3535 12.5% w/w, but lower repellent activity than DEET 20% w/w. The Cananga odorata oil in coconut oil exhibited excellent activity with 98.9% protection from bites of A. aegypti for 88.7 +/- 10.4 min. In addition, Cymbopogon citratus in olive oil showed excellent activity with 98.8% protection from bites of Culex quinquefasciatus for 170.0 +/- 9.0 min. While, DEET 20% w/w gave protection for 155.0 +/- 7.1-182.0 +/- 12.2 min and 98.5% protection from bites of two mosquito species. However, all herbal repellent provided lower repellency activity (97.4-98.9% protection for 10.5-88.7 min) against Aedes aegypti than Culex quinquefasciatus (98.3-99.2% protection for 60-170 min). Our data exhibited that Cananga odorata oil and Cymbopogon citratus oil are suitable to be used as green repellents for mosquito control, which are safe for humans, domestic animals and environmental friendly. (C) 2014 Elsevier B.V. All rights reserved.
C1 [Soonwera, Mayura] King Mongkuts Inst Technol Ladkrabang, Fac Agr Technol, Plant Prod Technol Sect, Bangkok 10520, Thailand.
[Phasornkusolsill, Siriporn] US Army, Med Component, Armed Forces Res Inst Med Sci, Dept Entomol, Bangkok 10400, Thailand.
RP Phasornkusolsill, S (reprint author), US Army, Med Component, Armed Forces Res Inst Med Sci, Dept Entomol, Bangkok 10400, Thailand.
EM msiriporn@hotmail.com
FU Faculty of Agricultural Technology, King Mongkut's Institute of
Technology Ladkrabang (KMITL), Bangkok, Thailand
FX The authors are highly grateful to Faculty of Agricultural Technology,
King Mongkut's Institute of Technology Ladkrabang (KMITL), Bangkok,
Thailand for providing financial assistance to carry out this study.
Grateful thanks are due to the volunteers from Plant Production
Technology Section, Faculty of Agricultural Technology, KMITL for their
assistance in repellent tests. Thanks are extended to plant taxonomist
of Faculty of Agricultural Technology, KMITL for herbal identification.
The standard disclaimer that the findings/conclusions reflect the
efforts and opinions of the authors and not of the US Army or AFRIMS or
the Department of Entomology.
NR 20
TC 3
Z9 3
U1 6
U2 24
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0001-706X
EI 1873-6254
J9 ACTA TROP
JI Acta Trop.
PD FEB
PY 2015
VL 142
BP 127
EP 130
DI 10.1016/j.actatropica.2014.11.010
PG 4
WC Parasitology; Tropical Medicine
SC Parasitology; Tropical Medicine
GA CA8UU
UT WOS:000349197200019
PM 25438256
ER
PT J
AU Reiter, MJ
Schwope, RB
Bui-Mansfield, LT
Lisanti, CJ
Glasgow, SC
AF Reiter, Michael J.
Schwope, Ryan B.
Bui-Mansfield, Liem T.
Lisanti, Christopher J.
Glasgow, Sean C.
TI Surgical Management of Retrorectal Lesions: What the Radiologist Needs
to Know
SO AMERICAN JOURNAL OF ROENTGENOLOGY
LA English
DT Review
DE CT; MRI; presacral; retrorectal
ID EXTRAMEDULLARY HEMATOPOIESIS; RETROPERITONEAL FIBROSIS; PRESACRAL
TUMORS; IMAGING FINDINGS; TAILGUT CYSTS; ADULTS; SPACE; CT; BIOPSY;
MASSES
AB OBJECTIVE. The purpose of this article is to highlight the most salient imaging features of retrorectal masses with regard to surgical planning, preoperative biopsy, and identification of nonneoplastic mimickers of malignancy.
CONCLUSION. Retrorectal tumors are associated with high morbidity. CT and MRI aid in preoperative planning because surgical resection is the treatment of choice for both benign and malignant entities. Radiologists need to understand the operative techniques currently used for retrorectal tumors because the first attempt at excision is the best chance for complete resection and optimal outcome.
C1 [Reiter, Michael J.; Schwope, Ryan B.; Bui-Mansfield, Liem T.; Lisanti, Christopher J.] Brooke Army Med Ctr, Dept Radiol, San Antonio, TX 78234 USA.
[Glasgow, Sean C.] Brooke Army Med Ctr, Dept Surg, San Antonio, TX USA.
RP Reiter, MJ (reprint author), Brooke Army Med Ctr, Dept Radiol, 3551 Roger Brooke Dr, San Antonio, TX 78234 USA.
EM mikereiter13@yahoo.com
NR 36
TC 2
Z9 2
U1 0
U2 0
PU AMER ROENTGEN RAY SOC
PI RESTON
PA 1891 PRESTON WHITE DR, SUBSCRIPTION FULFILLMENT, RESTON, VA 22091 USA
SN 0361-803X
EI 1546-3141
J9 AM J ROENTGENOL
JI Am. J. Roentgenol.
PD FEB
PY 2015
VL 204
IS 2
BP 386
EP 395
DI 10.2214/AJR.14.12791
PG 10
WC Radiology, Nuclear Medicine & Medical Imaging
SC Radiology, Nuclear Medicine & Medical Imaging
GA CA1DD
UT WOS:000348652300044
PM 25615762
ER
PT J
AU Bui-Mansfield, LT
Chen, DC
O'Brien, SD
AF Bui-Mansfield, Liem T.
Chen, Dillon C.
O'Brien, Seth D.
TI Accuracy of Ultrasound of Musculoskeletal Soft-Tissue Tumors
SO AMERICAN JOURNAL OF ROENTGENOLOGY
LA English
DT Letter
ID MASSES
C1 [Bui-Mansfield, Liem T.; Chen, Dillon C.; O'Brien, Seth D.] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA.
RP Bui-Mansfield, LT (reprint author), Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA.
NR 4
TC 2
Z9 2
U1 0
U2 0
PU AMER ROENTGEN RAY SOC
PI RESTON
PA 1891 PRESTON WHITE DR, SUBSCRIPTION FULFILLMENT, RESTON, VA 22091 USA
SN 0361-803X
EI 1546-3141
J9 AM J ROENTGENOL
JI Am. J. Roentgenol.
PD FEB
PY 2015
VL 204
IS 2
BP W218
EP W218
DI 10.2214/AJR.14.13335
PG 1
WC Radiology, Nuclear Medicine & Medical Imaging
SC Radiology, Nuclear Medicine & Medical Imaging
GA CA1DD
UT WOS:000348652300017
PM 25615787
ER
PT J
AU Williams, KS
Labukas, JP
Rodriguez-Santiago, V
Andzelm, JW
AF Williams, Kristen S.
Labukas, Joseph P.
Rodriguez-Santiago, Victor
Andzelm, Jan W.
TI First Principles Modeling of Water Dissociation on Mg(0001) and
Development of a Mg Surface Pourbaix Diagram
SO CORROSION
LA English
DT Article
DE magnesium; modeling; potential-pH diagram; thermodynamics; water
ID DENSITY-FUNCTIONAL THEORY; EARTH METAL-IONS; DOPED MG(0001);
HYDROGENATION MECHANISM; 1ST-PRINCIPLES CALCULATIONS;
ELECTRONIC-STRUCTURE; OXYGEN REDUCTION; AB-INITIO; MAGNESIUM; MOLECULES
AB Density functional theory (DFT) was used to study water dissociation on the Mg(0001) surface. The metal/water interface was modeled with a supercell approach, consisting of an extended metal surface coupled to an implicit solvent medium. Several electrochemical reactions were studied on the Mg surface, and it was found that dissociation of adsorbed water is thermodynamically favorable, and that the Mg(0001) surface has multiple 'active sites' that can accommodate adsorbed hydroxyl groups (*OH). This is similar to previous first principles findings of oxygen adsorption on Mg(0001). It was also found that the local structure of an adsorbed hydroxyl monolayer mimics that of the crystal structure of brucite, Mg(OH)(2). Lastly, DFT-calculated reaction enthalpies were used to reproduce the bulk Mg Pourbaix diagram, and Pourbaix's formalism was extended to develop a theoretical Mg surface Pourbaix diagram. From this, it was shown that the enthalpy of hydroxylation of Mg(0001) becomes more negative with increasing surface coverage of *OH groups. This indicates that the presence of adsorbed *OH species provides an energetic driving force for water dissociation on Mg(0001). Furthermore, the corrosive region of the Mg Pourbaix diagram can be suppressed if *OH adsorption is limited to certain low-energy active sites, where they form a stable hydroxide surface.
C1 [Williams, Kristen S.; Labukas, Joseph P.; Rodriguez-Santiago, Victor; Andzelm, Jan W.] US Army Res Lab, Mat & Mfg Sci Div, Aberdeen Proving Ground, MD 21005 USA.
RP Williams, KS (reprint author), US Army Res Lab, RDRL WMM G 4600 Deer Creek Loop, Aberdeen Proving Ground, MD 21005 USA.
EM kristen.s.williams7.ctr@mail.mil
FU U.S. Department of Energy; USARL
FX K.W. and V.R.S. are supported in part by an appointment to the
Postgraduate Research Participation Program at the U.S. Army Research
Laboratory, administered by the Oak Ridge Institute for Science and
Education through an interagency agreement between the U.S. Department
of Energy and USARL. This work was also supported in part by a grant of
computer time from the DoD High Performance Computing Modernization
Program at the U.S. Air Force Research Laboratory DoD Supercomputing
Resource Center.
NR 81
TC 5
Z9 5
U1 15
U2 47
PU NATL ASSOC CORROSION ENG
PI HOUSTON
PA 1440 SOUTH CREEK DRIVE, HOUSTON, TX 77084-4906 USA
SN 0010-9312
EI 1938-159X
J9 CORROSION
JI Corrosion
PD FEB
PY 2015
VL 71
IS 2
BP 209
EP 223
DI 10.5006/1322
PG 15
WC Materials Science, Multidisciplinary; Metallurgy & Metallurgical
Engineering
SC Materials Science; Metallurgy & Metallurgical Engineering
GA CA6IP
UT WOS:000349015600009
ER
PT J
AU Kennedy, AJ
Laird, JG
Lounds, C
Gong, P
Barker, ND
Brasfield, SM
Russell, AL
Johnson, MS
AF Kennedy, Alan J.
Laird, Jennifer G.
Lounds, Chris
Gong, Ping
Barker, Natalie D.
Brasfield, Sandra M.
Russell, Amber L.
Johnson, Mark S.
TI INTER- AND INTRASPECIES CHEMICAL SENSITIVITY: A CASE STUDY USING
2,4-DINITROANISOLE
SO ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY
LA English
DT Article
DE Dinitroanisole; Dinitrophenol; Toxicity; Insensitive munition; Species
sensitivity
ID INSENSITIVE MUNITIONS COMPOUND; SPECIES SENSITIVITY; DAPHNIA-MAGNA;
DNAN; CONSTITUENTS; TOXICITY; MS
AB Insensitive munitions offer increased safety because of their insensitivity to unintended detonation relative to historically used formulations such as 2,4,6-trinitrotoluene (TNT). Dinitroanisole (DNAN) is an insensitive munition constituent, and its solubility and stability warrant investigations of potential toxicological hazard related to manufacturing discharges and training ranges. Although ecotoxicology data are available for other insensitive munition constituents, few data are available for DNAN. In the present study, acute and chronic exposures of a fish (Pimephales promelas) and 2 cladocerans (Ceriodaphnia dubia, Daphnia pulex) were conducted. The 50% lethal concentration (LC50) values of DNAN ranged from 14.2mg/L to 42.0mg/L, depending on species. In chronic exposures, fish survival (LC50=10.0mg/L) was more sensitive than cladoceran survival (LC50=13.7 to >24.2mg/L). However, cladoceran reproduction was equally or more sensitive to DNAN (50% inhibition values 2.7-10.6mg/L, depending on species) than fish endpoints. Daphnia pulex was the most sensitive species, with only slight differences between the 3 populations tested. Although the aquatic toxicity of DNAN was lower than previously reported in the literature for TNT, future research is needed to determine the potential synergistic toxicity of all the constituents in insensitive munition mixtures and the implications of photo-oxidation. Environ Toxicol Chem 2014;9999:1-10. (c) 2014 SETAC
C1 [Kennedy, Alan J.; Laird, Jennifer G.; Brasfield, Sandra M.] US Army Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA.
[Lounds, Chris; Gong, Ping; Barker, Natalie D.; Russell, Amber L.] Badger Tech Serv, San Antonio, TX USA.
[Johnson, Mark S.] US Army Inst Publ Hlth, Aberdeen Proving Ground, MD USA.
RP Kennedy, AJ (reprint author), US Army Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA.
EM Alan.J.Kennedy@usace.army.mil
FU Army Environmental Quality Technology Basic Research Program (US Army
Engineer Research and Development Center); Strategic Environmental
Research and Development Program [ER 2223]
FX This work was funded by the Army Environmental Quality Technology Basic
Research Program (US Army Engineer Research and Development Center, E.
Ferguson, Technical Director) and the Strategic Environmental Research
and Development Program (Project ER 2223). We appreciate J. Smith and J.
Chappell (US Army Engineer Research and Development Center) for HPLC
analysis and D. Morrow (US Army Institute of Public Health) for gas
chromatography analysis. We thank H. Webb and A. Beckerman for donating
D. pulex for our internal cultures. We appreciate constructive comments
from 2 internal (J. Stanley, J. Johnson) and 4 anonymous reviewers.
Permission was granted by the chief of engineers to publish this
information.
NR 40
TC 3
Z9 3
U1 3
U2 25
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0730-7268
EI 1552-8618
J9 ENVIRON TOXICOL CHEM
JI Environ. Toxicol. Chem.
PD FEB
PY 2015
VL 34
IS 2
BP 402
EP 411
DI 10.1002/etc.2819
PG 10
WC Environmental Sciences; Toxicology
SC Environmental Sciences & Ecology; Toxicology
GA CA6BU
UT WOS:000348994200023
PM 25476794
ER
PT J
AU Ledford, CJW
Canzona, MR
Seehusen, DA
Cafferty, LA
Schmidt, ME
Huang, JC
Villagran, MM
AF Ledford, Christy J. W.
Canzona, Mollie R.
Seehusen, Dean A.
Cafferty, Lauren A.
Schmidt, Monica E.
Huang, Joseph C.
Villagran, Melinda M.
TI Differences in Physician Communication When Patients Ask Versus Tell
About Religion/Spirituality: A Pilot Study
SO FAMILY MEDICINE
LA English
DT Article
ID MEDICAL ENCOUNTERS; SPIRITUALITY; PARTICIPATION; RELIGION;
CONSULTATIONS; CARE; BELIEFS
AB BACKGROUND AND OBJECTIVES: Research suggests that physicians should pursue spiritual issues and that patients desire to discuss religion/spirituality (R/S) in medical encounters. This study explored the differences in physician communication in response to patient inquiry or disclosure of R/S and hypothesizes that physician communication will differ when patients disclose R/S as contrasted to inquire about R/S.
METHODS: Family physicians and family medicine resident physicians were recruited from a family medicine department at a community hospital (n=27). An objective structured clinical examination, with a standardized patient encounter, was used to expose the participants to a conversation regarding R/S. Participants were assigned, by alternating clustered assignment, to two conditions: patient disclosure of R/S or patient inquiry about physician R/S. The primary outcome measure was physician response, specifically physician-control, partnership-building, and supportive-talk messages.
RESULTS: When the patient asks questions about R/S, physicians communicate more control messages and less supportive talk messages than when the patient discloses information about R/S.
CONCLUSIONS: Training physicians to anticipate and respond to patient disclosure and inquiry will increase the likelihood they can enact patient-centered strategies. These methods should focus on teaching residents how to be sensitive to the R/S context of their patients and to recognize their own intuitive reactions to patient communication in that context.
C1 [Ledford, Christy J. W.] Univ Hlth Sci, Dept Family Med, Uniformed Serv, Bethesda, MD 20815 USA.
[Canzona, Mollie R.] George Mason Univ, Fairfax, VA 22030 USA.
[Seehusen, Dean A.] Eisenhower Army Med Ctr, Dept Family & Community Med, Ft Gordon, GA USA.
[Schmidt, Monica E.; Huang, Joseph C.] Ft Belvoir Community Hosp, Dept Family Med, Ft Belvoir, VA USA.
[Cafferty, Lauren A.; Villagran, Melinda M.] Texas State Univ San Marcos, San Marcos, TX USA.
RP Ledford, CJW (reprint author), Univ Hlth Sci, Dept Family Med, Uniformed Serv, Bethesda, MD 20815 USA.
EM christian.ledford@usuhs.edu
FU Fort Belvoir Community Hospital Department of Clinical Investigations
FX Ethical approval was granted by Fort Belvoir Community Hospital
Department of Clinical Investigations.
NR 34
TC 2
Z9 3
U1 1
U2 4
PU SOC TEACHERS FAMILY MEDICINE
PI LEAWOOD
PA 11400 TOMAHAWK CREEK PARKWAY, STE 540, LEAWOOD, KS 66207 USA
SN 0742-3225
EI 1938-3800
J9 FAM MED
JI Fam. Med.
PD FEB
PY 2015
VL 47
IS 2
BP 138
EP 142
PG 5
WC Primary Health Care; Medicine, General & Internal
SC General & Internal Medicine
GA CA9WS
UT WOS:000349276100009
PM 25646987
ER
PT J
AU Cole, DM
AF Cole, David M.
TI Laboratory observations of frictional sliding of individual contacts in
geologic materials
SO GRANULAR MATTER
LA English
DT Article
DE Contact mechanics; Friction; Experiments; Granular media; Coefficient of
friction
ID INITIAL FRICTION; ROUGH SURFACES; ROCK FRICTION; MECHANICS;
MICROMECHANICS; COEFFICIENT
AB This paper gives the results of grain-to-grain sliding friction experiments on several naturally occurring geologic materials and two manufactured materials. The materials include quartz sands with mean grain size ranging from 0.14 to 3 mm, crushed and ball milled gneiss with mm, magnesite (limestone) with mm, and Caicos ooids with mm. The reference materials include manufactured glass beads ( and 1.0 mm) and spheres of a synthetic material (Delrin, and 5.08 mm). The experiments involved normal loads that ranged from 0.46 to 20 N, depending on material, and the subsequent application of an increasing shear force at a loading rate of 1 . This work contributes to the goal of providing high-fidelity contact models for use in discrete element simulations of naturally occurring granular materials. The results presented here provide a picture of shear force-displacement behavior up to and through the onset of macroscopic sliding. For natural materials with relatively rough surfaces, the coefficient of friction ranged from 0.1 to 0.9 at normal force levels N, but tended to converge to a narrower range (0.24-0.62) at higher levels. Grains with low surface roughness (glass beads, synthetic material and the 3-mm-diameter sand), on the other hand, exhibited a trend of decreasing with increasing , with terminal values in the range of 0.1-0.2 for N. This behavior is explained in terms of the relationship between the normal force and the true area of contact. Additionally, observations of free sliding observed under cyclic shear loading are reported.
C1 Engn Res & Dev Ctr, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA.
RP Cole, DM (reprint author), Engn Res & Dev Ctr, Cold Reg Res & Engn Lab, 72 Lyme Rd, Hanover, NH 03755 USA.
EM David.M.Cole@usace.army.mil
FU ERDC's Military Engineering Basic Research Program
FX The author gratefully acknowledges the financial support of ERDC's
Military Engineering Basic Research Program. This work was made possible
by the excellent technical support of Douglas Punt, William Burch and
John Gagnon of ERDC-CRREL. Helpful comments on the manuscript from Dr.
Mark Hopkins of ERDC-CRREL are gratefully acknowledged.
NR 32
TC 2
Z9 2
U1 0
U2 11
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1434-5021
EI 1434-7636
J9 GRANUL MATTER
JI Granul. Matter
PD FEB
PY 2015
VL 17
IS 1
BP 95
EP 110
DI 10.1007/s10035-014-0526-0
PG 16
WC Materials Science, Multidisciplinary; Mechanics; Physics, Applied
SC Materials Science; Mechanics; Physics
GA CA6ND
UT WOS:000349030100008
ER
PT J
AU Crawford, KW
Wakabi, S
Magala, F
Kibuuka, H
Liu, M
Hamm, TE
AF Crawford, K. W.
Wakabi, S.
Magala, F.
Kibuuka, H.
Liu, M.
Hamm, T. E.
TI Evaluation of treatment outcomes for patients on first-line regimens in
US President's Emergency Plan for AIDS Relief (PEPFAR) clinics in
Uganda: predictors of virological and immunological response from RV288
analyses
SO HIV MEDICINE
LA English
DT Article
DE first-line regimen; sub-Saharan Africa; treatment outcomes; Uganda; US
President's Emergency Plan for AIDS Relief (PEPFAR); virological
suppression
ID HUMAN-IMMUNODEFICIENCY-VIRUS; T-CELL RECOVERY; ACTIVE ANTIRETROVIRAL
THERAPY; HIV-INFECTED PATIENTS; TOTAL LYMPHOCYTE COUNT; REFERENCE
RANGES; IMMUNE ACTIVATION; DRUG-RESISTANCE; VIRAL LOAD; ADULTS
AB ObjectivesViral load (VL) monitoring is recommended, but seldom performed, in resource-constrained countries. RV288 is a US President's Emergency Plan for AIDS Relief (PEPFAR) basic programme evaluation to determine the proportion of patients on treatment who are virologically suppressed and to identify predictors of virological suppression and recovery of CD4 cell count. Analyses from Uganda are presented here.
MethodsIn this cross-sectional, observational study, patients on first-line antiretroviral therapy (ART) (efavirenz or nevirapine+zidovudine/lamivudine) from Kayunga District Hospital and Kagulamira Health Center were randomly selected for a study visit that included determination of viral load (HIV-1 RNA), CD4 cell count and clinical chemistry tests. Subjects were recruited by time on treatment: 6-12, 13-24 or >24 months. Logistic regression modelling identified predictors of virological suppression. Linear regression modelling identified predictors of CD4 cell count recovery on ART.
ResultsWe found that 85.2% of 325 subjects were virologically suppressed (viral load<47 HIV-1 RNA copies/ml). There was no difference in the proportion of virologically suppressed subjects by time on treatment, yet CD4 counts were higher in each successive stratum. Women had higher median CD4 counts than men overall (406 vs. 294 cells/L, respectively; P<0.0001) and in each time-on-treatment stratum. In a multivariate logistic regression model, predictors of virological suppression included efavirenz use [odds ratio (OR) 0.47; 95% confidence interval (CI) 0.22-1.02; P=0.057], lower cost of clinic visits (OR 0.815; 95% CI 0.66-1.00; P=0.05), improvement in CD4 percentage (OR 1.06; 95% CI 1.014-1.107; P=0.009), and care at Kayunga vs.Kangulamira (OR 0.47; 95% CI 0.23-0.92; P=0.035). In a multivariate linear regression model of covariates associated with CD4 count recovery, time on highly active antiretroviral therapy (ART) (P<0.0001), patient satisfaction with care (P=0.038), improvements in total lymphocyte count (P<0.0001) and haemoglobin concentration (P=0.05) were positively associated, whereas age at start of ART (P=0.0045) was negatively associated with this outcome.
ConclusionsHigh virological suppression rates are achievable on first-line ART in Uganda. The odds of virological suppression were positively associated with efavirenz use and improvements in CD4 cell percentage and total lymphocyte count and negatively associated with the cost of travel to the clinic. CD4 cell reconstitution was positively associated with CD4 count at study visit, time on ART, satisfaction with care at clinic, haemoglobin concentration and total lymphocyte count and negatively associated with age.
C1 [Crawford, K. W.; Liu, M.; Hamm, T. E.] Walter Reed Army Inst Res, Global Hlth Programs, US Mil HIV Res Program MHRP, Bethesda, MD USA.
[Crawford, K. W.; Liu, M.; Hamm, T. E.] Henry M Jackson Fdn Adv Mil Med, Bethesda, MD USA.
[Wakabi, S.; Magala, F.; Kibuuka, H.] Makerere Univ, Walter Reed Program, Kampala, Uganda.
RP Crawford, KW (reprint author), 100 Seaton Pl NW,First floor, Washington, DC 20001 USA.
EM kwcrawford1@gmail.com
FU Henry M. Jackson Foundation for the Advancement of Military Medicine,
Inc. [W81XWH-07-2-0067]; US Department of Defense (DoD)
[W81XWH-07-2-0067]; US President's Emergency Plan for AIDS Relief
(PEPFAR)
FX This work was supported by a cooperative agreement (W81XWH-07-2-0067)
between the Henry M. Jackson Foundation for the Advancement of Military
Medicine, Inc., and the US Department of Defense (DoD). This research
was funded, in part, by the US President's Emergency Plan for AIDS
Relief (PEPFAR). The views expressed are those of the authors and should
not be construed to represent the positions of the US Army or DoD.
NR 56
TC 8
Z9 8
U1 1
U2 2
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1464-2662
EI 1468-1293
J9 HIV MED
JI HIV Med.
PD FEB
PY 2015
VL 16
IS 2
BP 95
EP 104
DI 10.1111/hiv.12177
PG 10
WC Infectious Diseases
SC Infectious Diseases
GA CA2AW
UT WOS:000348712300004
PM 25124078
ER
PT J
AU von Schweinitz, BA
De Lorenzo, RA
Cuenca, PJ
Anschutz, RL
Allen, PB
AF von Schweinitz, Benjamin A.
De Lorenzo, Robert A.
Cuenca, Peter J.
Anschutz, Richard L.
Allen, Paul B.
TI Does a non-invasive hemoglobin monitor correlate with a venous blood
sample in the acutely ill?
SO INTERNAL AND EMERGENCY MEDICINE
LA English
DT Article
DE Point-of-care; Hemoglobin; Analysis; Emergency care; Human
ID PULSE CO-OXIMETRY; ACCURACY; SURGERY; CARE; HEMOCUE(R); SPHB
AB Non-invasive hemoglobin measuring technology has potential for rapid, portable, and accurate way of providing identification of blood loss or anemia. Our objective is to determine if this technology is reliable in critically ill patients presenting to the Emergency Department. Prospective cross-sectional observational study was done at an urban level-one trauma center, 135 subjects were conveniently sampled, suspected of having active bleeding, sepsis, or other critically ill condition. Non-invasive measurements with Masimo (Irvine, CA, USA) Radical-7 and Rad-57 hemoglobin monitors were compared with the Beckman-Coulter LH-550 (Brea, CA, USA) clinical laboratory blood cell analyzer. The primary outcome was the relationship of the non-invasive device to the clinical laboratory results. Secondary evaluations included the effect of pulse rate, systolic BP, respiratory rate, temperature, capillary refill, skin color, nail condition, extremity movement. The Radical-7 was able to capture reading in 78 % (88/113) of subjects, and the Rad-57 in 65 % (71/110) of subjects. The correlation (R-2) of the device Hb was 0.69 and 0.67 (p < 00.01) for the Radical-7 and Rad-57, respectively. The coefficient of variation for the Radical-7 was 18 %, and for the Rad57 it was 13 %. Univariate analysis shows none of the observed factors is associated with the difference values between the device Hb and laboratory Hb. Our results show that Radical-7 and Rad-57 devices do not report readings in 29 % of patients and accuracy is significantly lower than reported by the manufacturer with over 50 % of readings falling outside of +/- A 1 g/dL. We determined that none of the several potential factors examined are associated with the degree of device accuracy.
C1 [von Schweinitz, Benjamin A.; Cuenca, Peter J.; Anschutz, Richard L.; Allen, Paul B.] San Antonio Mil Med Ctr, Dept Emergency Med, Jbsa Ft Sam Houston, TX 78234 USA.
[von Schweinitz, Benjamin A.] San Antonio Uniformed Serv Hlth Educ Consortium, Jbsa Ft Sam Houston, TX 78234 USA.
[De Lorenzo, Robert A.] US Army Inst Surg Res, Tact Combat Casualty Care Res Program, Jbsa Ft Sam Houston, TX 78234 USA.
[De Lorenzo, Robert A.; Cuenca, Peter J.] Univ Texas Hlth Sci Ctr San Antonio, Dept Emergency Med, San Antonio, TX 78229 USA.
RP von Schweinitz, BA (reprint author), San Antonio Uniformed Serv Hlth Educ Consortium, 3551 Roger Brooke Dr, Jbsa Ft Sam Houston, TX 78234 USA.
EM Benjamin.vonschweinitz@gmail.com; Robert.A.DeLorenzo.mil@mail.mil
FU Telemedicine and Advance Technology Research Center, US Army Medical
Research and Material Command, Fort Detrick, MD, USA
FX This study was supported by a grant from the Telemedicine and Advance
Technology Research Center, US Army Medical Research and Material
Command, Fort Detrick, MD 21702 USA. Thanks to James K. Aden, PhD for
his thoughtful statistical analysis. Special thanks to Olivia E.
Dominguez and Vanessa N. Ellis for their tireless efforts as research
technicians.
NR 19
TC 3
Z9 3
U1 1
U2 2
PU SPRINGER-VERLAG ITALIA SRL
PI MILAN
PA VIA DECEMBRIO, 28, MILAN, 20137, ITALY
SN 1828-0447
EI 1970-9366
J9 INTERN EMERG MED
JI Intern. Emerg. Med.
PD FEB
PY 2015
VL 10
IS 1
BP 55
EP 61
DI 10.1007/s11739-014-1129-9
PG 7
WC Medicine, General & Internal
SC General & Internal Medicine
GA CA6BK
UT WOS:000348993200010
PM 25322853
ER
PT J
AU Sajo, E
Wallace, W
Lumley, A
Heimbuch, B
Donahue, K
Nielsen, B
Owens, J
Wander, J
AF Sajo, Erno
Wallace, William
Lumley, April
Heimbuch, Brian
Donahue, Kristian
Nielsen, Bruce
Owens, Jeffery
Wander, Joseph
TI Capture of aerosolized spores from air streams impinging onto fabrics
SO JOURNAL OF AEROSOL SCIENCE
LA English
DT Article
DE Aerosol; Airlock; Boundary layer; Deposition; Modeling; Spores
ID DEPOSITION; RECOVERY; SURFACES; DRY
AB The zero-volume airlock concept minimizes the volume of air in and transiting through the airlock by effusing air from the clean area through spaces between deformable air bladders. An individual transiting through the airlock into a shelter displaces the bladders and creates ephemeral regions of varying dimensions and air velocities, which affect deposition and reaerosolization of particles. Properties of the aerosols and bladder surfaces are also influences, so the airlock may be treated to shed or retain particles and possibly to promote decontamination of them; the uniform material determines the protection from or exposure to these particles that the wearer experiences. To initiate evolution of a predictive computational model for the deposition and disposition of airborne particles in an airlock, this study presents measurements of deposition rates of Bacillus atrophaeus spores, a common simulant for anthrax spores, on a variety of fabrics as a function of airspeed and angle of incidence at similar to 22 degrees C and similar to 55% RH in a laboratory-scale aerosol tunnel. A computational model using inert surface properties consistently underpredicted experimental results by a factor of 2-10, suggesting that the variation in results across the test panel can be exploited to generate empirical parameters that can be substituted into the model to improve its predictive capability. Factors and possible approaches to computational descriptions are considered. Published by Elsevier Ltd.
C1 [Sajo, Erno] Univ Massachusetts, Dept Phys, Lowell, MA 01854 USA.
[Wallace, William; Lumley, April; Heimbuch, Brian] Appl Res Associates Inc, Panama City, FL 32401 USA.
[Donahue, Kristian] US Army, RDECOM, Natick, MA 01760 USA.
[Nielsen, Bruce] Air Force Res Lab, Tyndall AFB, FL 32403 USA.
[Owens, Jeffery; Wander, Joseph] Air Force Civil Engineer Ctr, Tyndall AFB, FL 32403 USA.
RP Wander, J (reprint author), Air Force Civil Engineer Ctr, Tyndall AFB, FL 32403 USA.
EM joseph.wander@us.af.mil
FU Defense Threat Reduction Agency [CA08PRO0002]
FX The authors thank Warwick Mills for providing the test fabrics via the
Army Natick Soldier RD&E Center, Karen Farrington for the
high-magnification EM images, and the Defense Threat Reduction Agency
for funding this effort as part of Project CA08PRO0002, Reactive Airlock
Technologies for Collective Protection Applications. The literature
searches that support this effort were performed by staff of the
Technical Information Center at Tyndall AFB, for whose assistance we are
greatly appreciative.
NR 22
TC 1
Z9 1
U1 0
U2 5
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0021-8502
EI 1879-1964
J9 J AEROSOL SCI
JI J. Aerosol. Sci.
PD FEB
PY 2015
VL 80
BP 75
EP 85
DI 10.1016/j.jaerosci.2014.10.010
PG 11
WC Engineering, Chemical; Engineering, Mechanical; Environmental Sciences;
Meteorology & Atmospheric Sciences
SC Engineering; Environmental Sciences & Ecology; Meteorology & Atmospheric
Sciences
GA CA8TD
UT WOS:000349192900006
ER
PT J
AU Colombo, CJ
Stachura, M
Wood, E
George, A
Broughton, R
AF Colombo, C. J.
Stachura, M.
Wood, E.
George, A.
Broughton, R.
TI AUTOMATED URINE FLOW RATE AND VOLUME MEASUREMENT: VALIDATION OF A NOVEL
SYSTEM
SO JOURNAL OF INVESTIGATIVE MEDICINE
LA English
DT Meeting Abstract
CT Southern Regional Meeting of the
American-Federation-for-Medical-Research
CY FEB 26-28, 2015
CL New Orleans, LA
SP Amer Federat Med Res
C1 [Colombo, C. J.; George, A.; Broughton, R.] Dwight D Eisenhower Army Med Ctr, Ft Gordon, GA USA.
[Stachura, M.; Wood, E.] Georgia Regents Univ, Augusta, GA USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1081-5589
EI 1708-8267
J9 J INVEST MED
JI J. Invest. Med.
PD FEB
PY 2015
VL 63
IS 2
MA 148
BP 367
EP 367
PG 1
WC Medicine, General & Internal; Medicine, Research & Experimental
SC General & Internal Medicine; Research & Experimental Medicine
GA CA0GM
UT WOS:000348595000159
ER
PT J
AU Rudy, RQ
Smith, GL
DeVoe, DL
Polcawich, RG
AF Rudy, Ryan Q.
Smith, Gabriel L.
DeVoe, Don L.
Polcawich, Ronald G.
TI Millimeter-Scale Traveling Wave Rotary Ultrasonic Motors
SO JOURNAL OF MICROELECTROMECHANICAL SYSTEMS
LA English
DT Article
DE Micromotors; piezoelectric films; traveling wave devices; PZT ceramics
ID PZT
AB Bidirectional rotary motion of a millimeter-scale traveling wave ultrasonic motor is demonstrated using solution-deposited thin-film lead zirconate titanate and wafer-scale microelectromechanical system fabrication techniques. Rotation speeds of a motor 3 mm in diameter have been characterized up to 2000 r/min as a function of voltage, phase, and frequency, with power consumption less than 4 mW. Frequency characterization shows no nonlinear behavior, while phase characterization shows that motion can be generated with a single source drive. Furthermore, imprint in the piezoelectric response was exploited to achieve higher speeds, starting voltages lower than 4 V, and demonstration of a 2-mm diameter motor up to 1730 r/min. Design and fabrication of the motors are also presented. [2013-0032]
C1 [Rudy, Ryan Q.; Smith, Gabriel L.; Polcawich, Ronald G.] US Army Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA.
[Rudy, Ryan Q.; DeVoe, Don L.] Univ Maryland, Dept Mech Engn, College Pk, MD 20742 USA.
RP Rudy, RQ (reprint author), US Army Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA.
EM ryan.q.rudy.ctr@mail.mil; gabriel.l.smith.12.civ@mail.mil; ddev@umd.edu;
ronald.g.polcawich.civ@mail.mil
RI DeVoe, Don/A-2891-2011
OI DeVoe, Don/0000-0002-7740-9993
FU Science, Mathematics, and Research for Transformation (SMART) Program
FX The work of R. Q. Rudy was supported by the Science, Mathematics, and
Research for Transformation (SMART) Program. Subject Editor K. F.
Bohringer.
NR 23
TC 5
Z9 5
U1 11
U2 41
PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
PI PISCATAWAY
PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA
SN 1057-7157
EI 1941-0158
J9 J MICROELECTROMECH S
JI J. Microelectromech. Syst.
PD FEB
PY 2015
VL 24
IS 1
BP 108
EP 114
DI 10.1109/JMEMS.2014.2317778
PG 7
WC Engineering, Electrical & Electronic; Nanoscience & Nanotechnology;
Instruments & Instrumentation; Physics, Applied
SC Engineering; Science & Technology - Other Topics; Instruments &
Instrumentation; Physics
GA CA8JG
UT WOS:000349164300014
ER
PT J
AU Scott, AM
Burns, EA
Lafferty, BJ
Hill, FC
AF Scott, Andrea Michalkova
Burns, Elizabeth A.
Lafferty, Brandon J.
Hill, Frances C.
TI Theoretical predictions of thermodynamic parameters of adsorption of
nitrogen containing environmental contaminants on kaolinite
SO JOURNAL OF MOLECULAR MODELING
LA English
DT Article
DE Binding; Clay; Distribution; Modeling; Nitroaromatic
ID DENSITY-FUNCTIONAL THEORY; SPACE GAUSSIAN PSEUDOPOTENTIALS; AB-INITIO;
CLAY-MINERALS; SUBSTITUTED NITROBENZENES; ORGANOCHLORINE PESTICIDES;
NITROAROMATIC EXPLOSIVES; NONCOVALENT INTERACTIONS; CARBONACEOUS
MATERIALS; SILICA SURFACES
AB In this study thermodynamic parameters of adsorption of nitrogen containing environmental contaminants ( NCCs, 2,4,6, trinitrotoluene (TNT), 2,4-dinitrotoluene (DNT), 2,4-dinitroanisole (DNAN), and 3-one-1,2,4-triazol-5-one (NTO)) interacting with the tetrahedral and octahedral surfaces of kaolinite were predicted. Adsorption complexes were investigated using a density functional theory and both periodic and cluster approach. The complexes, modeled using the periodic boundary conditions approach, were fully optimized at the BLYP-D2 level to obtain the structures and adsorption energies. The relaxed kaolinite-NCCs structures were used to prepare cluster models to calculate thermodynamic parameters and partition coefficients at the M06-2X-D3 and BLYP-D2 levels from the gas phase. The entropy effect on the Gibbs free energies of adsorption of NCCS on kaolinite was also studied and compared with available experimental data. The results showed that in all calculated models, the NCCs molecules are physisorbed and they favor a parallel orientation toward both kaolinite surfaces. It was found that all calculated NCCs compounds are more stable on the octahedral than on the tetrahedral surface of kaolinite. The Gibbs free energies and partition coefficients were also predicted for interactions of NCCs with Na-kaolinite from aqueous solution. Calculations revealed adsorption of NCCs is effective from the gas phase on both cation free kaolinite surfaces and on Na-kaolinite from aqueous solution at room temperature. Theoretical data were validated against experimental results, and the reasons for small differences between calculated and measured partition coefficients are discussed.
C1 [Scott, Andrea Michalkova; Lafferty, Brandon J.; Hill, Frances C.] US Army Engn Res & Dev Ctr ERDC, Vicksburg, MS 39180 USA.
[Burns, Elizabeth A.] Badger Tech Serv LLC, Vicksburg, MS 39180 USA.
RP Scott, AM (reprint author), US Army Engn Res & Dev Ctr ERDC, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA.
EM andrea.m.scott@usace.army.mil
FU Environmental Quality Technology Program of the United States Army Corps
of Engineers by the US Army ERDC
FX This work was facilitated by support from the High Performance Computing
Distributed Shared Resource Center at the ERDC (Vicksburg, MS). The use
of trade, product, or firm names in this report is for descriptive
purposes only and does not imply endorsement by the U.S. Government.
Results in this study were funded and obtained from research conducted
under the Environmental Quality Technology Program of the United States
Army Corps of Engineers by the US Army ERDC. Permission was granted by
the Chief of Engineers to publish this information. The findings of this
report are not to be construed as an official Department of the Army
position unless so designated by other authorized documents.
NR 87
TC 2
Z9 2
U1 1
U2 18
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1610-2940
EI 0948-5023
J9 J MOL MODEL
JI J. Mol. Model.
PD FEB
PY 2015
VL 21
IS 2
AR 21
DI 10.1007/s00894-015-2577-5
PG 16
WC Biochemistry & Molecular Biology; Biophysics; Chemistry,
Multidisciplinary; Computer Science, Interdisciplinary Applications
SC Biochemistry & Molecular Biology; Biophysics; Chemistry; Computer
Science
GA CA5XO
UT WOS:000348981900002
PM 25620422
ER
PT J
AU Penn-Barwell, JG
Baker, B
Wenke, JC
AF Penn-Barwell, Jowan G.
Baker, Brett
Wenke, Joseph C.
TI Local Bismuth Thiols Potentiate Antibiotics and Reduce Infection in a
Contaminated Open Fracture Model
SO JOURNAL OF ORTHOPAEDIC TRAUMA
LA English
DT Article
DE open fractures; infection; injury; biofilm; antibiotics; debridement;
wounds; bismuth thiols; orthopaedic medical device; osteosynthesis;
bismuth
ID PSEUDOMONAS-AERUGINOSA; IN-VITRO; POLYURETHANE SCAFFOLDS; ANTIBACTERIAL
ACTIVITY; SEGMENTAL DEFECT; RAT FEMUR; BIOFILMS; WOUNDS; COMBAT;
POLYSACCHARIDE
AB Objective: This proof-of-concept study tested the hypothesis that combining bismuth thiols (BTs) with systemic antibiotics will more effectively reduce infection in an animal model of contaminated open fracture than systemic antibiotics alone.
Methods: An implant-stabilized segmental defect rat model was contaminated with Staphylococcus aureus and then treated with surgical debridement 6 hours after injury and 3 days of systemic cefazolin. A single dose of BTs suspended in a hydrogel was administered to the wound immediately after debridement. After 14 days, the bone and implant were harvested for microbiological analysis.
Results: A single local dose of 0.05 mg of BT (MB-8-2), when combined with systemically administered cefazolin, decreased infection, without any noticeable local or systemic toxicity, from 60% to 10% (P = 0.002), with only 0.02% of the recovered bacteria quantity of the cefazolin-only group (P < 0.001). Higher doses were less effective and caused side-effects.
Conclusions: BTs administered locally to infected open fracture wounds at an appropriate dose potentiate the effect of systemically administered antibiotics and reduce infection rate and bacteria quantity associated with bone and orthopaedic implants. Local delivery of BTs is a promising strategy for increasing the efficacy of systemically administered antibiotics in preventing and treating infections of open fractures.
C1 [Penn-Barwell, Jowan G.; Wenke, Joseph C.] US Army, Inst Surg Res, Extrem Trauma Bone Grp, San Antonio, TX 78234 USA.
[Penn-Barwell, Jowan G.] Royal Ctr Def Med, Acad Dept Mil Surg & Trauma, Birmingham, W Midlands, England.
[Baker, Brett] Microbion Biosci Corp, Bozeman, MT USA.
RP Wenke, JC (reprint author), US Army, Inst Surg Res, Extrem Trauma Bone Grp, 3698 Chambers Pass, Ft Sam Houston, TX 78234 USA.
EM joseph.c.wenke.civ@mail.mil
NR 38
TC 1
Z9 2
U1 1
U2 7
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0890-5339
EI 1531-2291
J9 J ORTHOP TRAUMA
JI J. Orthop. Trauma
PD FEB
PY 2015
VL 29
IS 2
BP E73
EP E78
PG 6
WC Orthopedics; Sport Sciences
SC Orthopedics; Sport Sciences
GA CA3TH
UT WOS:000348828500011
PM 24978943
ER
PT J
AU Song, DJ
Cook, JB
Krul, KP
Bottoni, CR
Rowles, DJ
Shaha, SH
Tokish, JM
AF Song, Daniel J.
Cook, Jay B.
Krul, Kevin P.
Bottoni, Craig R.
Rowles, Douglas J.
Shaha, Steve H.
Tokish, John M.
TI High frequency of posterior and combined shoulder instability in young
active patients
SO JOURNAL OF SHOULDER AND ELBOW SURGERY
LA English
DT Article
DE Shoulder instability; posterior shoulder instability; combined shoulder
instability
ID GLENOID LABRUM; CIRCUMFERENTIAL LESIONS; ARTHROSCOPIC REPAIR; FOLLOW-UP;
MANAGEMENT; DIAGNOSIS; PATHOLOGY; MRI
AB Objective: The purpose of this study was to describe the epidemiology and demographics of surgically treated shoulder instability stratified by direction. We hypothesized that there would be an increased frequency of posterior and combined shoulder instability in our population compared with published literature. Secondarily, we assessed preoperative magnetic resonance imaging (MRI) reports to determine how accurately they detected the pathology addressed at surgery.
Materials and methods: A retrospective review was conducted at a single facility during a 46-month period. The study included all patients who underwent an operative intervention for shoulder instability. The instability in each case was characterized as isolated anterior, isolated posterior, or combined, according to pathologic findings confirmed at arthroscopy. The findings were retrospectively compared with official MRI reports to determine the accuracy of MRI in characterizing the clinically and operatively confirmed diagnosis.
Results: A consecutive series of 231 patients (221 men, 10 women) underwent stabilization for shoulder instability over 46 months. Patients were a mean age of 26.0 years. There were 132 patients (57.1%) with isolated anterior instability, 56 (24.2%) with isolated posterior instability, and 43 18.6%) with combined instability. Overall, MRI findings completely characterized the clinical diagnosis and arthroscopic pathology in 149 of 219 patients (68.0%).
Conclusion: The rate of posterior and combined instability in an active population is more common than has been previously reported, making up more than 40% of operatively treated instability, including a previously unreported incidence of 19% for combined instabilities. In addition, MRI was often incomplete or inaccurate in detecting the pathology eventually treated at surgery. Published by Elsevier Inc. on behalf of Journal of Shoulder and Elbow Surgery Board of Trustees.
C1 [Song, Daniel J.] Landstuhl Reg Med Ctr, Orthopaed Surg Serv, D-09180 Landstuhl, Germany.
[Cook, Jay B.; Krul, Kevin P.; Bottoni, Craig R.; Rowles, Douglas J.; Tokish, John M.] Tripler Army Med Ctr, Orthoped Surg Serv, Honolulu, HI 96859 USA.
[Shaha, Steve H.] Univ Utah, Ctr Publ Policy & Adm, Salt Lake City, UT USA.
[Shaha, Steve H.] Allscripts, Chicago, IL USA.
[Tokish, John M.] Steadman Hawkins Clin Carolinas, Greenville, SC USA.
RP Song, DJ (reprint author), Landstuhl Reg Med Ctr, Orthopaed Surg Serv, CMR 402 Box 445,APO,AE, D-09180 Landstuhl, Germany.
EM song_daniel@hotmail.com
NR 23
TC 8
Z9 8
U1 0
U2 1
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1058-2746
J9 J SHOULDER ELB SURG
JI J. Shoulder Elbow Surg.
PD FEB
PY 2015
VL 24
IS 2
BP 186
EP 190
DI 10.1016/j.jse.2014.06.053
PG 5
WC Orthopedics; Sport Sciences; Surgery
SC Orthopedics; Sport Sciences; Surgery
GA AY7DJ
UT WOS:000347721200010
PM 25219471
ER
PT J
AU Swab, JJ
Tice, J
Wereszczak, AA
Kraft, RH
AF Swab, Jeffrey J.
Tice, Jason
Wereszczak, Andrew A.
Kraft, Reuben H.
TI Fracture Toughness of Advanced Structural Ceramics: Applying ASTM C1421
SO JOURNAL OF THE AMERICAN CERAMIC SOCIETY
LA English
DT Article
ID TOUGHENED SILICON-NITRIDE; SUBCRITICAL CRACK-GROWTH;
EDGE-PRECRACKED-BEAM; R-CURVE BEHAVIOR; SURFACE-CRACK; FLEXURE METHOD;
RESISTANCE; ALUMINA; SHAPE; SIZE
AB The three methods of determining the quasi-static Mode I fracture toughness (K-Ic) (surface crack in flexureSC, single-edge precracked beamPB, and chevron-notched beamVB) found in ASTM C1421 were applied to a variety of advanced ceramic materials. All three methods produced valid and comparable K-Ic values for the Al2O3, SiC, Si3N4, and SiAlON ceramics examined. However, not all methods could successfully be applied to B4C, ZrO2, and WC ceramics due to a variety of material factors. The coarse-grained microstructure of one B4C hindered the ability to observe and measure the precracks generated in the SC and PB methods while the transformation toughening in the ZrO2 prevented the formation of the SC and PB precracks and thus made it impossible to use either method on this ceramic. The high strength and elastic modulus of the WC made it impossible to achieve stable crack growth using the VB method because the specimen stored a tremendous amount of energy prior to fracture. Even though these methods have passed the rigors of the standardization process there are still some issues to be resolved when the methods are applied to certain classes of ceramics. It is recommended that, when appropriate, at least two of these methods be employed to determine the K-Ic, especially when a new or unfamiliar ceramic is being evaluated.
C1 [Swab, Jeffrey J.; Tice, Jason; Kraft, Reuben H.] Army Res Lab, Aberdeen Proving Ground, MD 21005 USA.
[Wereszczak, Andrew A.] Oak Ridge Natl Lab, Oak Ridge, TN 37831 USA.
[Tice, Jason] Univ Maryland Baltimore Cty, Baltimore, MD 21228 USA.
[Tice, Jason; Kraft, Reuben H.] Harford Community Coll, Bel Air, MD USA.
RP Swab, JJ (reprint author), Army Res Lab, Aberdeen Proving Ground, MD 21005 USA.
EM jeffrey.j.swab.civ@mail.mil
RI Wereszczak, Andrew/I-7310-2016
OI Wereszczak, Andrew/0000-0002-8344-092X
FU US Army Research Laboratory (USARL)
FX Work performed while an undergraduate student at the University of
Maryland Baltimore County and with support by an appointment to the
Research Participation Program at the US Army Research Laboratory
(USARL) administered by the Oak Ridge Institute for Science and
Education through an interagency agreement between USARL and the US
Department of Energy.
NR 31
TC 1
Z9 1
U1 1
U2 30
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0002-7820
EI 1551-2916
J9 J AM CERAM SOC
JI J. Am. Ceram. Soc.
PD FEB
PY 2015
VL 98
IS 2
BP 607
EP 615
DI 10.1111/jace.13293
PG 9
WC Materials Science, Ceramics
SC Materials Science
GA CA1HC
UT WOS:000348662400040
ER
PT J
AU Edwards, MJ
Lustik, MB
Clark, ME
Creamer, KM
Tuggle, D
AF Edwards, Mary J.
Lustik, Michael B.
Clark, Margaret E.
Creamer, Kevin M.
Tuggle, David
TI The effects of balanced blood component resuscitation and crystalloid
administration in pediatric trauma patients requiring transfusion in
Afghanistan and Iraq 2002 to 2012
SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY
LA English
DT Article
DE Pediatric; hemorrhage; resuscitation; crystalloid; transfusion
ID MASSIVE TRANSFUSION; WHOLE-BLOOD; INJURIES; CHILDREN; THERAPY; PROMMTT
AB BACKGROUND: Component balanced resuscitation and avoidance of crystalloids in traumatically injured adults requiring massive transfusion are beneficial. Evidence for children is lacking.
METHODS: After institutional review board approval was obtained, the Department of Defense Trauma Database identified 1,311 injured children 14 years or younger requiring transfusion after an injury and admitted to a deployed US military hospital from 2002 to 2012. Logistic regression determined risk factors for high-volume (>= 40 mL/kg) or massive (>= 70 mL/kg) transfusions. The effects of crystalloid and balanced component resuscitation in the first 24 hours were assessed.
RESULTS: Nine hundred seven patients had recorded data sufficient for analysis. Two hundred twenty-four children received high-volume transfusion, and 77 received massive transfusions. Mortality was significantly higher for massive transfusions and high-volume transfusions than others (25% vs. 10% and 19% vs. 9%, respectively). Age of less than 4 years, penetrating injury, and Injury Severity Score (ISS) greater than 15 were associated with high-volume transfusions; an ISS greater than 15 and penetrating injury were associated with massive transfusions. Increased crystalloid administration showed a significant positive association with hospital days and intensive care unit days for both massive and high-volume transfusions, as well as a significant positive association with increased ventilator days in patients with high-volume transfusions. Balanced component resuscitation was not associated with improved measured outcomes and was independently associated with a higher mortality when all transfused patients were considered.
CONCLUSION: In this cohort, heavy reliance on crystalloid for resuscitation had an adverse effect on outcomes. Balanced component resuscitation did not improve outcomes and was associated with higher mortality when all transfused patients were considered. Further study is needed regarding efficacy and clinical triggers for the implementation of massive transfusion in children. (Copyright (C) 2015 Wolters Kluwer Health, Inc. All rights reserved.)
LEVEL OF EVIDENCE: Prognostic study, level IV.
C1 [Edwards, Mary J.] San Antonio Mil Med Ctr, Dept Surg, San Antonio, TX 78234 USA.
[Tuggle, David] UT Southwestern, Dept Trauma, Dell Childrens Med Ctr, Austin, TX USA.
[Lustik, Michael B.] Tripler Army Med Ctr, Dept Clin Invest, Honolulu, HI 96859 USA.
[Clark, Margaret E.] Tripler Army Med Ctr, Dept Surg, Honolulu, HI 96859 USA.
[Creamer, Kevin M.] Childrens Natl Med Ctr, Hospitalist Div, Washington, DC 20010 USA.
RP Edwards, MJ (reprint author), San Antonio Mil Med Ctr, Dept Surg, 3551 Roger Brooke Dr, San Antonio, TX 78234 USA.
EM mary.j.edwards.mil@mail.mil
NR 20
TC 2
Z9 2
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 2163-0755
EI 2163-0763
J9 J TRAUMA ACUTE CARE
JI J. Trauma Acute Care Surg.
PD FEB
PY 2015
VL 78
IS 2
BP 330
EP 335
DI 10.1097/TA.0000000000000469
PG 6
WC Critical Care Medicine; Surgery
SC General & Internal Medicine; Surgery
GA CA3TF
UT WOS:000348828300017
PM 25757119
ER
PT J
AU Roy, TC
Ritland, BM
Sharp, MA
AF Roy, Tanja C.
Ritland, Bradley M.
Sharp, Marilyn A.
TI A Description of Injuries in Men and Women While Serving in Afghanistan
SO MILITARY MEDICINE
LA English
DT Article
ID LOW-BACK-PAIN; OPERATIONS IRAQI FREEDOM; FEMALE ARMY TRAINEES;
RISK-FACTORS; ENDURING FREEDOM; PHYSICAL-FITNESS; US ARMY; CONSTRUCTION
ENGINEERS; OUTPATIENT VISITS; TRAINING-PROGRAM
AB Musculoskeletal injuries (MSIs) are the most common cause of ambulatory visits in the deployed setting. Research done on deployed populations have focused mostly on men. The purpose of this retrospective cohort study was to describe physical demands and MSIs among male and female soldiers in a Brigade Combat Team during a 12-month deployment to Afghanistan. Data on occupational tasks and injuries were collected from the infantry and brigade support battalions. Out of 57 women, 22 had MSIs (39%) and for the 536 men, 120 (22%) had MSIs resulting in limited duty. The average limited duty was 7.5 and 13 days/injury for women and men, respectively. The most commonly injured body region for the men was the low back (32%) and the low back (22%) and foot and ankle (22%) for women. The activity associated with MSI for women was physical training (25%) and for men it was contact with the enemy (23%). Physically demanding duties, more distance walked, and heavier average load and objects lifted all increased the risk of injury in women. Only lifting heavier weights increased the risk in men. The women appear to have less tolerance to physically demanding work such than their male counterparts.
C1 [Roy, Tanja C.; Ritland, Bradley M.; Sharp, Marilyn A.] US Army, Environm Med Res Inst, Natick, MA 01760 USA.
RP Roy, TC (reprint author), US Army, Environm Med Res Inst, 15 Kansas St, Natick, MA 01760 USA.
FU Soldiers of the Infantry Battalion [4/23]; Brigade Support Battalion,
Fort Lewis, Washington; U.S. Army Medical Research and Materiel Command
under Task Area S
FX The authors would like to thank the Soldiers of the 4/23 Infantry
Battalion and 402nd Brigade Support Battalion, Fort Lewis, Washington,
for their support and assistance with this study. This research was
funded by the U.S. Army Medical Research and Materiel Command under Task
Area S.
NR 34
TC 3
Z9 3
U1 1
U2 3
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
EI 1930-613X
J9 MIL MED
JI Milit. Med.
PD FEB
PY 2015
VL 180
IS 2
BP 126
EP 131
DI 10.7205/MILMED-D-14-00321
PG 6
WC Medicine, General & Internal
SC General & Internal Medicine
GA CA7MR
UT WOS:000349101900002
PM 25643377
ER
PT J
AU Chandrasekera, RM
Lesho, EP
Chukwuma, U
Cummings, JF
Waterman, PE
AF Chandrasekera, Ruvani M.
Lesho, Emil P.
Chukwuma, Uzo
Cummings, James F.
Waterman, Paige E.
TI The State of Antimicrobial Resistance Surveillance in the Military
Health System: A Review of Improvements Made in the Last 10 Years and
Remaining Surveillance Gaps
SO MILITARY MEDICINE
LA English
DT Review
ID METALLO-BETA-LACTAMASE; ANTIBIOTIC-RESISTANCE; ACINETOBACTER-BAUMANNII;
CARBAPENEM-RESISTANT; PROVIDENCIA-STUARTII; STAPHYLOCOCCUS-AUREUS;
KLEBSIELLA-PNEUMONIAE; ROUTINE SURVEILLANCE; WOUND INFECTIONS; CLINICAL
ISOLATE
AB During a military public health laboratory symposium held in 1999, concerns were raised that the military health system lacked a standardized antimicrobial resistance (AMR) surveillance system that allowed comparison of data across sites, investigation of trends, and understanding of resistance mechanisms. The purpose of this review was to assess if current AMR activities in the military health system have addressed the aforementioned gaps. It was determined that much progress has already been made within the Department of Defense with respect to monitoring and understanding AMR through initiatives such as the Antimicrobial Resistance Monitoring and Research Program-a strong Department of Defense-wide surveillance program. These surveillance efforts can be made more robust through harmonization of testing and reporting structures across military treatment facilities, and by encouraging military treatment facility participation.
C1 [Chandrasekera, Ruvani M.; Cummings, James F.; Waterman, Paige E.] Armed Forces Hlth Surveillance Ctr, Silver Spring, MD 20910 USA.
[Lesho, Emil P.] Walter Reed Army Inst Res, Multidrug Resistant Organism Rep & Surveillance N, Silver Spring, MD 20910 USA.
[Chukwuma, Uzo] Navy & Marine Corps Public Hlth Ctr, EpiData Ctr, Portsmouth, VA 23708 USA.
RP Chandrasekera, RM (reprint author), Armed Forces Hlth Surveillance Ctr, 503 Robert Grant Ave, Silver Spring, MD 20910 USA.
NR 46
TC 1
Z9 1
U1 2
U2 4
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
EI 1930-613X
J9 MIL MED
JI Milit. Med.
PD FEB
PY 2015
VL 180
IS 2
BP 145
EP 150
DI 10.7205/MILMED-D-14-00297
PG 6
WC Medicine, General & Internal
SC General & Internal Medicine
GA CA7MR
UT WOS:000349101900006
PM 25643381
ER
PT J
AU Kim, HC
Takhampunya, R
Tippayachai, B
Chong, ST
Park, JY
Kim, MS
Seo, HJ
Yeh, JY
Lee, WJ
Lee, DK
Klein, TA
AF Kim, Heung Chul
Takhampunya, Ratree
Tippayachai, Bousaraporn
Chong, Sung-Tae
Park, Jee-Yong
Kim, Myung-Soon
Seo, Hyun-Ji
Yeh, Jung-Yong
Lee, Won-Ja
Lee, Dong-Kyu
Klein, Terry A.
TI Japanese Encephalitis Virus in Culicine Mosquitoes (Diptera: Culicidae)
of the Republic of Korea, 2008-2010
SO MILITARY MEDICINE
LA English
DT Article
ID SOUTH-KOREA; GENOTYPE V; INFECTION; SURVEILLANCE; TRANSMISSION;
IMMUNIZATION; AMERICANS; THAILAND; ANTIBODY; FUTURE
AB A total of 150,805 culicine female mosquitoes were captured by Mosquito Magnet, black light, and New Jersey light traps, and at resting collections in the Republic of Korea from 2008 to 2010 as part of the U. S. Forces Korea malaria and Japanese surveillance programs. Mosquitoes were identified and culicine mosquitoes placed in pools of up to 30 mosquitoes each, by species and date of collection, and screened for flaviviruses using a reverse transcription-polymerase chain reaction assay. A total of 98/6,845 (1.4%) pools were positive by reverse transcription-polymerase chain reaction for Japanese encephalitis virus (JEV). A total of 92/2,031 (4.5%) pools of Culex tritaeniorhynchus were positive for JEV and accounted for 93.9% (92/98) of all JEV positive pools. A total of 4/804 (0.5%) and 2/175 (1.1%) pools of C. pipiens and C. bitaeniorhynchus, respectively, were positive for JEV. The JEV maximum likelihood estimations (estimated number of viral RNA positive mosquitoes per 1,000) for C. tritaeniorhynchus, C. bitaeniorhynchus, and C. pipiens were 1.71, 1.02, and 0.36 respectively. JEV is a severe health threat for local populations and of significant concern for nonimmune (unvaccinated) U.S. soldiers, civilians, and family members deployed to the Republic of Korea.
C1 [Takhampunya, Ratree; Tippayachai, Bousaraporn] Armed Forces Res Inst Med Sci, Dept Entomol, Bangkok 10400, Thailand.
[Park, Jee-Yong; Kim, Myung-Soon; Seo, Hyun-Ji] Anim & Plant Quarantine Agcy, Foreign Anim Dis Div, Anyang 430824, Gyeonggi, South Korea.
[Yeh, Jung-Yong] Univ Incheon, Coll Life Sci & Bioengn, Div Life Sci, Inchon 406772, South Korea.
[Lee, Won-Ja] Korea Ctr Dis Control & Prevent, NIH, Chungbuk 363951, South Korea.
[Lee, Dong-Kyu] Kosin Univ, Dept Hlth & Environm, Pusan 606701, South Korea.
[Klein, Terry A.] Publ Hlth Command Reg Pacific, Camp Zama, Japan.
[Klein, Terry A.] Force Hlth Protect & Prevent Med, Seoul, South Korea.
RP Kim, HC (reprint author), 5th Med Detachment, Seoul, South Korea.
FU Armed Forces Health Surveillance Center-Global Emerging Infections
Surveillance and Response System (AFHSC-GEIS), Silver Spring, MD;
Foreign Animal Disease Division, Animal and Plant Quarantine Agency,
Anyang, Gyeonggi Province, ROK; Korea National Institute of Health;
Korea Centers for Disease Control and Prevention, Osong, Chungcheongbuk
Province, ROK; Armed Forces Research Institute of Medical Sciences,
Bangkok, Thailand
FX We thank COL Hee-Choon S. Lee, Chief, Force Health Protection and
Preventive Medicine, 65th Medical Brigade, for his support. Special
thanks to Mr. Dong-Chan Kim (Daeseongdong village mayor), the ROK Army
Commander, and ROK Army soldiers at JSA (provide security for
Daeseongdong), for their assistance in mosquito collections. This work
was funded by the Armed Forces Health Surveillance Center-Global
Emerging Infections Surveillance and Response System (AFHSC-GEIS),
Silver Spring, MD, the Foreign Animal Disease Division, Animal and Plant
Quarantine Agency, Anyang, Gyeonggi Province, ROK, the Korea National
Institute of Health, the Korea Centers for Disease Control and
Prevention, Osong, Chungcheongbuk Province, ROK, and the Armed Forces
Research Institute of Medical Sciences, Bangkok, Thailand.
NR 56
TC 2
Z9 2
U1 0
U2 3
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
EI 1930-613X
J9 MIL MED
JI Milit. Med.
PD FEB
PY 2015
VL 180
IS 2
BP 158
EP 167
DI 10.7205/MILMED-D-14-00206
PG 10
WC Medicine, General & Internal
SC General & Internal Medicine
GA CA7MR
UT WOS:000349101900008
PM 25643383
ER
PT J
AU Walsh, DV
Capo-Aponte, JE
Jorgensen-Wagers, K
Temme, LA
Goodrich, G
Sosa, J
Riggs, DW
AF Walsh, David V.
Capo-Aponte, Jose E.
Jorgensen-Wagers, Kendra
Temme, Leonard A.
Goodrich, Gregory
Sosa, Josue
Riggs, Daniel W.
TI Visual Field Dysfunctions in Warfighters During Different Stages
Following Blast and Nonblast mTBI
SO MILITARY MEDICINE
LA English
DT Article
ID TRAUMATIC BRAIN-INJURY; DOUBLING TECHNOLOGY PERIMETRY;
NEUROOPHTHALMOLOGICAL FINDINGS; HEAD TRAUMA; FREQUENCY; REHABILITATION;
POPULATION; IMPAIRMENT; EYE
AB Objectives: Traumatic brain injury (TBI) is the leading injury coming out of the past decades' two major military conflicts, with mild TBI (mTBI) being the most commonly diagnosed form. The aim of this study was to assess the frequency and types of visual field (VF) defects seen at different testing stages following nonblast and blast-induced mTBI. Methods: A comprehensive retrospective review was performed on 500 electronic health records for military personnel sustaining an mTBI during deployment, of which 166 patients were tested with both confrontation VF and 30-2 Humphrey Matrix Frequency Doubling Technology (FDT) perimetry. Results: Scatter defects (48%) were the most predominantly found deficits in both blast and nonblast mTBI injury mechanisms and over postinjury test time frames. Confrontation VF was shown to be a poor qualitative predictor of VF defect. A profound decrease in VF sensitivity was noted in comparison to previously reported FDT normative data. Finally, a significant trend of decreasing VF defects was seen over time, indicating the potential usage of FDT as a visual biomarker for monitoring mTBI recovery. Conclusions: The findings of this study highlight the importance of performing threshold perimeter testing in those who have suffered an mTBI or concussion-like event.
C1 [Walsh, David V.; Capo-Aponte, Jose E.; Temme, Leonard A.; Sosa, Josue; Riggs, Daniel W.] US Army Aeromed Res Lab, Sensory Res Div, Visual Sci Branch, Ft Rucker, AL 36362 USA.
[Capo-Aponte, Jose E.] Womack Army Med Ctr, Dept Optometry, Ft Bragg, NC 28310 USA.
[Jorgensen-Wagers, Kendra] Landstuhl Reg Med Ctr, Traumat Brain Injury Clin, D-09180 Landstuhl, Germany.
[Goodrich, Gregory] Vet Affairs Palo Alto Hlth Care Syst, Psychol Serv & Western Blind Rehabil Ctr, Menlo Pk, CA 94025 USA.
RP Walsh, DV (reprint author), US Army Aeromed Res Lab, Sensory Res Div, Visual Sci Branch, 6901 Farrel Rd, Ft Rucker, AL 36362 USA.
FU Military Operational Medicine Research Program of the U.S. Army Medical
Research and Materiel Command
FX This research was funded by the Military Operational Medicine Research
Program of the U.S. Army Medical Research and Materiel Command.
NR 44
TC 2
Z9 2
U1 4
U2 5
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
EI 1930-613X
J9 MIL MED
JI Milit. Med.
PD FEB
PY 2015
VL 180
IS 2
BP 178
EP 185
DI 10.7205/MILMED-D-14-00230
PG 8
WC Medicine, General & Internal
SC General & Internal Medicine
GA CA7MR
UT WOS:000349101900010
PM 25643385
ER
PT J
AU Eckard, T
Lopez, J
Kaus, A
Aden, J
AF Eckard, Timothy
Lopez, Joseph
Kaus, Anna
Aden, James
TI Home Exercise Program Compliance of Service Members in the Deployed
Environment: An Observational Cohort Study
SO MILITARY MEDICINE
LA English
DT Article
ID LOW-BACK-PAIN; REHABILITATION; ADHERENCE; ADULTS
AB Background: Home exercise programs (HEP) are an integral part of any physical therapy treatment plan, but are especially important in theater. The primary aim of this study was to determine if the number of exercises prescribed in a HEP was associated with compliance rate of Service Members (SM) in theater with a secondary aim of determining variables associated with compliance and noncompliance. Materials/Methods: Subjects were 155 deployed SM undergoing physical therapy in Iraq and Afghanistan. Clinical evaluation and prescription of a HEP were performed. Pathologic, demographic, and treatment data were obtained. Subjects returned to the clinic 1 week later to demonstrate their HEP. Subjects' performance of each prescribed exercise was rated on a 12-point scale to quantify compliance. Results: 2 variables were found to be significantly associated with rate of compliance. These were the number of exercises prescribed (p = 0.02) and if a subject left the base at least once per week (p = 0.01). Conclusions: SM prescribed 4 or more exercises had a lower rate of compliance than those prescribed 2 or fewer. SM who left the base at least once per week also had a lower rate of compliance.
C1 [Eckard, Timothy] US Army Hlth Ctr, Phys Therapy Dept, Vicenza, Italy.
[Lopez, Joseph] Blanchfield Army Community Hosp, Phys Therapy Dept, Ft Campbell, KY 42223 USA.
[Kaus, Anna] Brooke Army Med Ctr, Phys Therapy Dept, Ft Sam Houston, TX 78234 USA.
[Aden, James] US Army, Inst Surg Res, Dept Stat & Epidemiol, Ft Sam Houston, TX 78234 USA.
RP Eckard, T (reprint author), US Army Hlth Ctr, Phys Therapy Dept, Vicenza, Italy.
NR 15
TC 2
Z9 2
U1 0
U2 9
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
EI 1930-613X
J9 MIL MED
JI Milit. Med.
PD FEB
PY 2015
VL 180
IS 2
BP 186
EP 191
DI 10.7205/MILMED-D-14-00306
PG 6
WC Medicine, General & Internal
SC General & Internal Medicine
GA CA7MR
UT WOS:000349101900011
PM 25643386
ER
PT J
AU Oh, RC
Arter, JL
Tiglao, SM
Larson, SL
AF Oh, Robert C.
Arter, Joel L.
Tiglao, Samuel M.
Larson, Shane L.
TI Exertional Rhabdomyolysis: A Case Series of 30 Hospitalized Patients
SO MILITARY MEDICINE
LA English
DT Article
ID SERUM CREATINE-KINASE
AB Introduction: Exertional rhabdomyolysis is a clinical entity of significant muscle breakdown in the setting of exercise. However, clinical course and discharge criteria, once hospitalized, are poorly described. We describe 30 cases of exertional rhabdomyolysis and their hospital course. Methods: Thirty hospitalized cases with ICD-9 code of 722.88 (rhabdomyolysis) as the primary diagnosis were reviewed from 2010 to 2012. We excluded those with associated trauma, toxin, and heat illnesses. Results: The average length of stay was 3.6 days (range: 1-8 days). Length of stay correlated significantly with peak creatine kinase (CK) levels. The mean admission CK was 61,391 U/L (range 697-233,180 U/L). The mean discharge CK was 23,865 U/L with a wide range (1,410-94,665 U/L). Six cases (20%) had evidence of acute kidney injury, but most had serum creatinine (Cr) < 1.7 mg/dL. One had a peak Cr of 4.8 mg/dL. Higher serum Cr levels correlated significantly with lower CK levels. Twenty-nine out of 30 patients were discharged when CKs downtrended. Conclusion: Higher peak CK levels predicted longer length of stay. Higher serum Cr significantly correlated with lower CK levels. There did not appear to be any threshold CK for admission or discharge, however, all but one patient were discharged after CK downtrended.
C1 [Oh, Robert C.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA.
[Arter, Joel L.] US Army Hlth Clin Schofield Barracks, Schofield Barracks, HI 96786 USA.
[Tiglao, Samuel M.] Tripler Army Med Ctr, Dept Family Med, Honolulu, HI 96859 USA.
RP Oh, RC (reprint author), Uniformed Serv Univ Hlth Sci, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA.
NR 15
TC 5
Z9 5
U1 0
U2 0
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
EI 1930-613X
J9 MIL MED
JI Milit. Med.
PD FEB
PY 2015
VL 180
IS 2
BP 201
EP 207
DI 10.7205/MILMED-D-14-00274
PG 7
WC Medicine, General & Internal
SC General & Internal Medicine
GA CA7MR
UT WOS:000349101900013
PM 25643388
ER
PT J
AU Wojcik, BE
Curley, KC
Szeszel-Fedorowicz, W
Stein, CR
Humphrey, RJ
AF Wojcik, Barbara E.
Curley, Kenneth C.
Szeszel-Fedorowicz, Wioletta
Stein, Catherine R.
Humphrey, Rebecca J.
TI Spinal Injury Hospitalizations Among US Army Soldiers Deployed to Iraq
and Afghanistan
SO MILITARY MEDICINE
LA English
DT Article
ID TRAUMATIC BRAIN-INJURY; IMPROVISED EXPLOSIVE DEVICE; COMBAT CASUALTY
CARE; MILITARY PERSONNEL; CORD INJURIES; FREEDOM; WARTIME; WOUNDS;
DEATH; BLAST
AB This retrospective study examined spinal-related hospitalizations of U.S. Army soldiers deployed to Afghanistan and Iraq. Spinal cord injuries (SCI) and vertebral column injuries (VCI) were identified using International Classification of Disease, 9th Revision, Clinical Modification diagnosis codes. In our study, spinal hospitalizations represented 8.2% of total injury admissions. Risk factors for SCI and VCI incidences were determined using Poisson regression. Lack of previous deployment experience increased risk of having SCI by 33% and VCI by 24% in Iraq (similar increases, but not statistically significant in Afghanistan). Male soldiers had 4.85 times higher risk for SCI in Iraq and 69% higher risk in Afghanistan than female soldiers. In Afghanistan, almost 60% of spinal episodes included traumatic brain injury (TBI), compared to about 40% in Iraq. In both theaters, mild TBI accounted for more than 50% of all TBI-spinal episodes. Sixteen percent of SCI inpatient episodes in Afghanistan and 13% in Iraq were associated with paralysis, with median bed days of 46 and 33 days compared to a median of 6 days in both theaters for nonparalysis spinal injuries. The mortality rate was 2.5 times lower in Afghanistan than in Iraq.
C1 [Wojcik, Barbara E.; Szeszel-Fedorowicz, Wioletta; Stein, Catherine R.; Humphrey, Rebecca J.] Ctr US Army Med Dept Strateg Studies, Ft Sam Houston, TX 78234 USA.
[Curley, Kenneth C.] US Army Med Res & Mat Command, Combat Casualty Care Directorate RAD2, Ft Detrick, MD 21702 USA.
RP Wojcik, BE (reprint author), Ctr US Army Med Dept Strateg Studies, 2478 Stanley Rd Suite 47, Ft Sam Houston, TX 78234 USA.
NR 36
TC 1
Z9 1
U1 0
U2 1
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
EI 1930-613X
J9 MIL MED
JI Milit. Med.
PD FEB
PY 2015
VL 180
IS 2
BP 216
EP 223
DI 10.7205/MILMED-D-14-000061
PG 8
WC Medicine, General & Internal
SC General & Internal Medicine
GA CA7MR
UT WOS:000349101900015
PM 25643390
ER
PT J
AU Cutter, L
AF Cutter, Laura
TI The Unusual Case of Private George Lemon
SO MILITARY MEDICINE
LA English
DT Editorial Material
C1 US Army Med Res & Mat Command, Amer Registry Pathol, Natl Museum Hlth & Med, Silver Spring, MD 20910 USA.
RP Cutter, L (reprint author), US Army Med Res & Mat Command, Amer Registry Pathol, Natl Museum Hlth & Med, 2500 Linden Lane, Silver Spring, MD 20910 USA.
NR 1
TC 0
Z9 0
U1 0
U2 0
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
EI 1930-613X
J9 MIL MED
JI Milit. Med.
PD FEB
PY 2015
VL 180
IS 2
BP 241
EP 242
DI 10.7205/MILMED-D-14-00522
PG 2
WC Medicine, General & Internal
SC General & Internal Medicine
GA CA7MR
UT WOS:000349101900019
PM 25643394
ER
PT J
AU Liu, JM
Pattanaik, S
Yao, JH
Dwyer, AJ
Pickhardt, PJ
Choi, JR
Summers, RM
AF Liu, Jiamin
Pattanaik, Sanket
Yao, Jianhua
Dwyer, Andrew J.
Pickhardt, Perry J.
Choi, J. Richard
Summers, Ronald M.
TI Associations Among Pericolonic Fat, Visceral Fat, and Colorectal Polyps
on CT Colonography
SO OBESITY
LA English
DT Article
DE colonic polyps; CT; colon; CT; virtual imaging; pericolonic fat
measurement; visceral fat measurement
ID ADIPOSE-TISSUE; CANCER; COLONOSCOPY; OBESITY; COLON; RISK
AB ObjectiveTo determine the association between pericolonic fat and colorectal polyps using CT colonography (CTC).
MethodsA total of 1169 patients who underwent CTC and optical colonoscopy on the same day were assessed. Pericolonic fat was measured on CTC in a band surrounding the colon. Visceral adipose tissue volume was measured at the L2-L3 levels. Student's t-tests, odds ratio, logistic regression, binomial statistics, and weighted kappa were performed to ascertain associations with the incidence of colorectal polyps.
ResultsPericolonic fat volume fractions (PFVF) were 61.511.0% versus 58.1 +/- 11.5%, 61.6 +/- 11.1% versus 58.7 +/- 11.5%, and 62.4 +/- 10.6% versus 58.8 +/- 11.5% for patients with and without any polyps, adenomatous polyps, and hyperplastic polyps, respectively (P<0.0001). Similar trends were observed when examining visceral fat volume fractions (VFVF). When patients were ordered by quintiles of PFVF or VFVF, there were 2.49-, 2.19-, and 2.39-fold increases in odds ratio for the presence of any polyp, adenomatous polyps, or hyperplastic polyps from the first to the fifth quintile for PFVF and 1.92-, 2.00-, and 1.71-fold increases in odds ratio for VFVF. Polyps tended to occur more commonly in parts of the colon that had more PFVF than the spatially adjusted average for patients in the highest quintile of VFVF.
ConclusionsPericolonic fat accumulations, like visceral fat, are correlated with an increased risk of adenomatous and hyperplastic polyps.
C1 [Liu, Jiamin; Pattanaik, Sanket; Yao, Jianhua; Dwyer, Andrew J.; Summers, Ronald M.] NIH, Imaging Biomarkers & Comp Aided Diag Lab, Ctr Clin, Bethesda, MD 20892 USA.
[Pickhardt, Perry J.] Univ Wisconsin, Dept Radiol, Sch Med, Clin Sci Ctr E3 311, Madison, WI 53706 USA.
[Choi, J. Richard] Walter Reed Army Med Ctr, Washington, DC 20307 USA.
RP Summers, RM (reprint author), NIH, Imaging Biomarkers & Comp Aided Diag Lab, Ctr Clin, Bldg 10, Bethesda, MD 20892 USA.
EM rms@nih.gov
FU Intramural Research Program of the National Institutes of Health,
Clinical Center
FX Intramural Research Program of the National Institutes of Health,
Clinical Center.
NR 25
TC 2
Z9 2
U1 1
U2 2
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1930-7381
EI 1930-739X
J9 OBESITY
JI Obesity
PD FEB
PY 2015
VL 23
IS 2
BP 408
EP 414
DI 10.1002/oby.20987
PG 7
WC Endocrinology & Metabolism; Nutrition & Dietetics
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA CA6QN
UT WOS:000349040400024
PM 25558027
ER
PT J
AU Tamburello, RN
Herrmann, JW
AF Tamburello, Robert N.
Herrmann, Jeffrey W.
TI A simulation-based approach to determine the evaluation adequacy of
system-of-systems operational test configurations
SO PROCEEDINGS OF THE INSTITUTION OF MECHANICAL ENGINEERS PART O-JOURNAL OF
RISK AND RELIABILITY
LA English
DT Article
DE System-of-systems; reliability; operational test; test configuration;
stochastic simulation; Monte Carlo; evaluation adequacy; test and
evaluation; reliability test program planning
AB A system-of-systems is defined as a set or arrangement of systems that results from independent systems integrated into a larger system that delivers unique capabilities. Given practical resource constraints, it is rare that the full-field configuration of the system-of-systems can be exercised during an operational reliability demonstration test. However, as we consider various potential operational test configurations for a given system-of-systems during the reliability test program planning process, it is critical to understand how testing a configuration that is smaller than the full-field configuration decreases the adequacy of the test by reducing the accuracy of the system-of-systems' reliability estimate that is based on the test results. Thus, it is useful to assess the adequacy of potential system-of-systems' operational test configurations before adopting one. We present a novel simulation-based method that can be employed to assess the adequacy of a given test configuration for any type of system-of-systems. To illustrate how this simulation-based method can be used to aid in the identification of the best alternative from among a group of potential operational test configuration alternatives, we include an example application using a notional air defense system-of-systems. Trade-offs with respect to cost, schedule, and accuracy are addressed within the context of this application.
C1 [Tamburello, Robert N.] US Army, Evaluat Ctr, Aberdeen Proving Ground, MD 21005 USA.
[Herrmann, Jeffrey W.] Univ Maryland, Dept Mech Engn, Syst Res Inst, College Pk, MD 20742 USA.
RP Tamburello, RN (reprint author), US Army, Evaluat Ctr, 2202 Aberdeen Blvd,ATTN 2nd Floor ISMED, Aberdeen Proving Ground, MD 21005 USA.
EM robert.n.tamburello.civ@mail.mil
NR 10
TC 0
Z9 0
U1 0
U2 3
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1748-006X
EI 1748-0078
J9 P I MECH ENG O-J RIS
JI Proc. Inst. Mech. Eng. Part O-J. Risk Reliab.
PD FEB
PY 2015
VL 229
IS 1
BP 46
EP 51
DI 10.1177/1748006X14549394
PG 6
WC Engineering, Multidisciplinary; Engineering, Industrial; Operations
Research & Management Science
SC Engineering; Operations Research & Management Science
GA CA9DU
UT WOS:000349221400005
ER
PT J
AU Cooper, CL
Bavari, S
AF Cooper, Christopher L.
Bavari, Sina
TI A race for an Ebola vaccine: promises and obstacles
SO TRENDS IN MICROBIOLOGY
LA English
DT Editorial Material
DE Ebola; vaccine; FDA clinical trial; immune correlates; durable immunity
ID VIRUS; IMMUNITY
AB While several impeding factors have limited Ebola vaccine development, the current epidemic has provided a surge which may lead to a record pace for a vaccine against Ebola. Consequently, multiple FDA trials are currently underway using two promising vaccine platforms; one has recently demonstrated durable immunity within non-human primates.
C1 [Cooper, Christopher L.; Bavari, Sina] US Army, Med Res Inst Infect Dis, Mol & Translat Sci, Ft Detrick, MD 21702 USA.
RP Bavari, S (reprint author), US Army, Med Res Inst Infect Dis, Mol & Translat Sci, Ft Detrick, MD 21702 USA.
EM sina.bavari.civ@mail.mil
NR 10
TC 10
Z9 10
U1 0
U2 21
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0966-842X
EI 1878-4380
J9 TRENDS MICROBIOL
JI Trends Microbiol.
PD FEB
PY 2015
VL 23
IS 2
BP 65
EP 66
DI 10.1016/j.tim.2014.12.005
PG 2
WC Biochemistry & Molecular Biology; Microbiology
SC Biochemistry & Molecular Biology; Microbiology
GA CB3AS
UT WOS:000349500700001
PM 25535021
ER
PT J
AU Fuller, ME
Hatzinger, PB
Condee, CW
Andaya, C
Vainberg, S
Michalsen, MM
Crocker, FH
Indest, KJ
Jung, CM
Eaton, H
Istok, JD
AF Fuller, Mark E.
Hatzinger, Paul B.
Condee, Charles W.
Andaya, Christina
Vainberg, Simon
Michalsen, Mandy M.
Crocker, Fiona H.
Indest, Karl J.
Jung, Carina M.
Eaton, Hillary
Istok, Jonathan D.
TI Laboratory evaluation of bioaugmentation for aerobic treatment of RDX in
groundwater
SO BIODEGRADATION
LA English
DT Article
DE RDX; Bioaugmentation; Bacterial transport; Degradation
ID SP STRAIN DN22; HEXAHYDRO-1,3,5-TRINITRO-1,3,5-TRIAZINE RDX; EXPLOSIVE
HEXAHYDRO-1,3,5-TRINITRO-1,3,5-TRIAZINE; BACTERIAL TRANSPORT; INTACT
CORES; RHODOCOCCUS; DEGRADATION; GORDONIA; BIODEGRADATION;
MINERALIZATION
AB The potential for bioaugmentation with aerobic explosive degrading bacteria to remediate hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) contaminated aquifers was demonstrated. Repacked aquifer sediment columns were used to examine the transport and RDX degradation capacity of the known RDX degrading bacterial strains Gordonia sp. KTR9 (modified with a kanamycin resistance gene) Pseudomonas fluorescens I-C, and a kanamycin resistant transconjugate Rhodococcus jostii RHA1 pGKT2:Km(+). All three strains were transported through the columns and eluted ahead of the conservative bromide tracer, although the total breakthrough varied by strain. The introduced cells responded to biostimulation with fructose (18 mg L-1, 0.1 mM) by degrading dissolved RDX (0.5 mg L-1, 2.3 A mu M). The strains retained RDX-degrading activity for at least 6 months following periods of starvation when no fructose was supplied to the column. Post-experiment analysis of the soil indicated that the residual cells were distributed along the length of the column. When the strains were grown to densities relevant for field-scale application, the cells remained viable and able to degrade RDX for at least 3 months when stored at 4 A degrees C. These results indicate that bioaugmentation may be a viable option for treating RDX in large dilute aerobic plumes.
C1 [Fuller, Mark E.; Hatzinger, Paul B.; Condee, Charles W.; Andaya, Christina; Vainberg, Simon] CB&I Fed Serv, Lawrenceville, NJ 08648 USA.
[Michalsen, Mandy M.] US Army Corps Engineers, Engn Design Branch, Seattle, WA 98134 USA.
[Crocker, Fiona H.; Indest, Karl J.; Jung, Carina M.] US Army Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA.
[Eaton, Hillary] Embry Riddle Aeronaut Univ, Dept Phys, Prescott, AZ 86301 USA.
[Istok, Jonathan D.] Oregon State Univ, Sch Civil & Construct Engn, Corvallis, OR 97331 USA.
RP Fuller, ME (reprint author), CB&I Fed Serv, 17 Princess Rd, Lawrenceville, NJ 08648 USA.
EM mark.fuller@cbifederalservices.com
FU Environmental Security Technology Certification Program (ESTCP)
[W912DW-12-C-0029]
FX This project was supported by the Environmental Security Technology
Certification Program (ESTCP) under contract W912DW-12-C-0029. Views,
opinions, and/or findings contained in this report are those of the
author(s) and should not be construed as an official Department of
Defense position or decision unless so designated by other official
documentation.
NR 40
TC 3
Z9 3
U1 1
U2 23
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0923-9820
EI 1572-9729
J9 BIODEGRADATION
JI Biodegradation
PD FEB
PY 2015
VL 26
IS 1
BP 77
EP 89
DI 10.1007/s10532-014-9717-y
PG 13
WC Biotechnology & Applied Microbiology
SC Biotechnology & Applied Microbiology
GA AZ8DL
UT WOS:000348444900007
PM 25503243
ER
PT J
AU Lesho, EP
Clifford, RJ
Chukwuma, U
Kwak, YI
Maneval, M
Neumann, C
Xie, S
Nielsen, LE
Julius, MD
McGann, P
Waterman, PE
AF Lesho, Emil P.
Clifford, Robert J.
Chukwuma, Uzo
Kwak, Yoon I.
Maneval, Mark
Neumann, Charlotte
Xie, Suji
Nielsen, Lindsey E.
Julius, Michael D.
McGann, Patrick
Waterman, Paige E.
TI Carbapenem-resistant Enterobacteriaceae and the correlation between
carbapenem and fluoroquinolone usage and resistance in the US military
health system
SO DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
LA English
DT Article
DE Antibiotic use; Antibiotic consumption; Healthcare network; Carbapenem
resistance
ID KLEBSIELLA-PNEUMONIAE; UNITED-STATES; ANTIBIOTIC USAGE; CARE FACILITIES;
K.-PNEUMONIAE; GLOBAL SPREAD; RISK-FACTORS; INFECTIONS; SURVEILLANCE;
BLOOD
AB Whether carbapenem or fluoroquinolone usage is correlated with carbapenem-resistant Enterobacteriaceae (CRE) has not been investigated at the level of an entire US nationwide managed health care system. We analyzed 75 million person-years of surveillance and 1,969,315 cultures from all 266 hospitals in the geographically dispersed US military health system. Incidences of CRE remained under 1 case per 100,000 person-years. Incidences of CRE increased relative to 2005 baseline levels in 3 of 7 subsequent years, then decreased in 2012 (P < 0.05). Incident proportions of carbapenem resistance (CR) differed significantly among years, geographical regions, and bacterial species. Although use and resistance strongly correlated (R > 0.80) for several "drug-bug" combinations, none were significant at the national or facility level. One exception was that inpatient consumption of fluoroquinolones was significantly correlated (P = 0.0007) with CR in Escherichia coli when data from the major referral centers of the Southern and Northern regions were combined. Published by Elsevier Inc.
C1 [Lesho, Emil P.; Clifford, Robert J.; Kwak, Yoon I.; Nielsen, Lindsey E.; Julius, Michael D.; McGann, Patrick; Waterman, Paige E.] Walter Reed Army Inst Res, Multidrugresistant Organism Repositoty & Surveill, Silver Spring, MD 20910 USA.
[Chukwuma, Uzo; Neumann, Charlotte] Navy & Marine Corps Public Hlth Ctr, EpiData Ctr Dept, Portsmouth, VA USA.
[Maneval, Mark; Xie, Suji] US Army, Pharmacovigilance Ctr, Falls Church, VA USA.
RP Lesho, EP (reprint author), Walter Reed Army Inst Res, Multidrugresistant Organism Repositoty & Surveill, Silver Spring, MD 20910 USA.
EM carolinelesho@yahoo.com
FU US Army Medical Command; Armed Forces Health Surveillance Center-Global
Emerging Infections Surveillance and Response System
FX This work was supported by the US Army Medical Command and the Armed
Forces Health Surveillance Center-Global Emerging Infections
Surveillance and Response System, who had no role in the collection or
analysis of data, nor the preparation of the manuscript.
NR 39
TC 1
Z9 1
U1 0
U2 5
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0732-8893
EI 1879-0070
J9 DIAGN MICR INFEC DIS
JI Diagn. Microbiol. Infect. Dis.
PD FEB
PY 2015
VL 81
IS 2
BP 119
EP 125
DI 10.1016/j.diagmicrobio.2014.09.017
PG 7
WC Infectious Diseases; Microbiology
SC Infectious Diseases; Microbiology
GA AZ8WD
UT WOS:000348491500010
PM 25497458
ER
PT J
AU Anders, MA
Lenahan, PM
Cochrane, CJ
Lelis, AJ
AF Anders, Mark A.
Lenahan, Patrick M.
Cochrane, Corey J.
Lelis, Aivars J.
TI Relationship Between the 4H-SiC/SiO2 Interface Structure and Electronic
Properties Explored by Electrically Detected Magnetic Resonance
SO IEEE TRANSACTIONS ON ELECTRON DEVICES
LA English
DT Article
DE 4H-silicon carbide (4H-SiC) MOSFET; defects; interface; magnetic
resonance
ID CHARGE-PUMPING MEASUREMENTS; CHANNEL MOBILITY; NITRIC-OXIDE; MOSFETS;
NITRIDATION; SILICON
AB In this paper, an exceptionally sensitive form of electron paramagnetic resonance called electrically detected magnetic resonance (EDMR) is utilized to investigate performance limiting imperfections at and very near the interface of 4H-silicon carbide MOSFETs. EDMR measurements are made over an extremely wide range of frequencies, 16 GHz-350 MHz. Multiple interface/near interface defects are identified and strong evidence for significant disorder at the interface region is presented.
C1 [Anders, Mark A.; Lenahan, Patrick M.] Penn State Univ, Dept Engn Sci & Mech, University Pk, PA 16801 USA.
[Cochrane, Corey J.] Penn State Univ, University Pk, PA 16801 USA.
[Lelis, Aivars J.] US Army Res Lab, Adelphi, MD 20783 USA.
RP Anders, MA (reprint author), Penn State Univ, Dept Engn Sci & Mech, University Pk, PA 16801 USA.
EM maa5297@psu.edu; pmlesm@engr.psu.edu; corey.j.cochrane@jpl.nasa.gov;
aivars.j.lelis.civ@mail.mil
FU U.S. Army Research Laboratory, Adelphi, MD, USA; U.S. Department of
Defense, Washington, DC, USA
FX This work was supported in part by the U.S. Army Research Laboratory,
Adelphi, MD, USA, and in part by the U.S. Department of Defense,
Washington, DC, USA. The review of this paper was arranged by Editor N.
Ohtani.
NR 31
TC 4
Z9 4
U1 2
U2 35
PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
PI PISCATAWAY
PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA
SN 0018-9383
EI 1557-9646
J9 IEEE T ELECTRON DEV
JI IEEE Trans. Electron Devices
PD FEB
PY 2015
VL 62
IS 2
BP 301
EP 308
DI 10.1109/TED.2014.2364722
PG 8
WC Engineering, Electrical & Electronic; Physics, Applied
SC Engineering; Physics
GA AZ7FZ
UT WOS:000348386100008
ER
PT J
AU Lelis, AJ
Green, R
Habersat, DB
El, M
AF Lelis, Aivars J.
Green, Ron
Habersat, Daniel B.
El, Mooro
TI Basic Mechanisms of Threshold-Voltage Instability and Implications for
Reliability Testing of SiC MOSFETs
SO IEEE TRANSACTIONS ON ELECTRON DEVICES
LA English
DT Article
DE Oxide trap; power MOSFET; reliability; silicon carbide (SiC); threshold
voltage
ID HIGH-TEMPERATURE RELIABILITY; CHARGE-PUMPING MEASUREMENTS; POWER
MOSFETS; MOS DEVICES; STRESS; DEPENDENCE; DMOSFET; TRAPS; STABILITY;
ISSUES
AB A review of the basic mechanisms affecting the stability of the threshold voltage in response to a bias-temperature stress is presented in terms of the charging and activation of near-interfacial oxide traps. An activation energy of approximately 1.1 eV was calculated based on new experimental results. Implications of these factors, including the recovery of some bias-temperature stress-activated defects, for improved device reliability testing are discussed.
C1 [Lelis, Aivars J.; Green, Ron; Habersat, Daniel B.; El, Mooro] US Army Res Lab, Adelphi, MD 20783 USA.
RP Lelis, AJ (reprint author), US Army Res Lab, Adelphi, MD 20783 USA.
EM aivars.j.lelis.civ@mail.mil; ronald.green39.civ@mail.mil;
daniel.b.habersat.civ@mail.mil; mooro.i.el.civ@mail.mil
NR 51
TC 23
Z9 23
U1 12
U2 64
PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
PI PISCATAWAY
PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA
SN 0018-9383
EI 1557-9646
J9 IEEE T ELECTRON DEV
JI IEEE Trans. Electron Devices
PD FEB
PY 2015
VL 62
IS 2
BP 316
EP 323
DI 10.1109/TED.2014.2356172
PG 8
WC Engineering, Electrical & Electronic; Physics, Applied
SC Engineering; Physics
GA AZ7FZ
UT WOS:000348386100010
ER
PT J
AU Indest, KJ
Eberly, JO
Ringelberg, DB
Hancock, DE
AF Indest, Karl J.
Eberly, Jed O.
Ringelberg, David B.
Hancock, Dawn E.
TI The effects of putative lipase and wax ester
synthase/acyl-CoA:diacylglycerol acyltransferase gene knockouts on
triacylglycerol accumulation in Gordonia sp KTR9
SO JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY
LA English
DT Article
DE Triacyglycerol; Lipase; WS/DGAT; Gordonia
ID RHODOCOCCUS-OPACUS PD630; SP STRAIN ADP1; CHLAMYDOMONAS-REINHARDTII;
DIACYLGLYCEROL ACYLTRANSFERASE; MYCOBACTERIUM-TUBERCULOSIS;
ESCHERICHIA-COLI; COENZYME-A; IDENTIFICATION; BIOSYNTHESIS; METABOLISM
AB Previously, we demonstrated triacylglycerol (TAG) accumulation and the in vivo ability to catalyze esters from exogenous short chain alcohol sources in Gordonia sp. strain KTR9. In this study, we investigated the effects that putative lipase (KTR9_0186) and wax ester synthase/acyl-CoA:diacylglycerol acyltransferase (WS/DGAT; KTR9_3844) gene knockouts had on TAG accumulation. Gene disruption of KTR9_0186 resulted in a twofold increase in TAG content in nitrogen starved cells. Lipase mutants subjected to carbon starvation, following nitrogen starvation, retained 75 % more TAGs and retained pigmentation. Transcriptome expression data confirmed the deletion of KTR9_0186 and identified the up-regulation of key genes involved in fatty acid degradation, a likely compensatory mechanism for reduced TAG mobilization. In vitro assays with purified KTR9_3844 demonstrated WS/DGAT activity with short chain alcohols and C16 and C18 fatty acid Co-As. Collectively, these results indicate that Gordonia sp. KTR9 has a suitable tractable genetic background for TAG production as well as the enzymatic capacity to catalyze fatty acid esters from short chain alcohols.
C1 [Indest, Karl J.; Eberly, Jed O.; Hancock, Dawn E.] US Army Engineer Res & Dev Ctr, Environm Lab, CEERD EP P, Vicksburg, MS 39180 USA.
[Ringelberg, David B.] US Army Engineer Res & Dev Ctr, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA.
RP Indest, KJ (reprint author), US Army Engineer Res & Dev Ctr, Environm Lab, CEERD EP P, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA.
EM indestk@wes.army.mil
FU US Army Engineer Research and Development Center's Basic Research
Program [10-50]
FX This research was funded through the US Army Engineer Research and
Development Center's Basic Research Program (Project 10-50, K. J.
Indest). Views, opinions and/or findings contained herein are those of
the authors and should not be construed as an official Department of the
Army position or decision unless so designated by other official
documentation.
NR 30
TC 1
Z9 1
U1 4
U2 19
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1367-5435
EI 1476-5535
J9 J IND MICROBIOL BIOT
JI J. Ind. Microbiol. Biotechnol.
PD FEB
PY 2015
VL 42
IS 2
BP 219
EP 227
DI 10.1007/s10295-014-1552-y
PG 9
WC Biotechnology & Applied Microbiology
SC Biotechnology & Applied Microbiology
GA AZ7RT
UT WOS:000348416300007
PM 25487758
ER
PT J
AU Perry, J
Stankorb, SM
Salgueiro, M
AF Perry, Jeffery
Stankorb, Susan M.
Salgueiro, Marybeth
TI Microbial Contamination of Enteral Feeding Products in Thermoneutral and
Hyperthermal ICU Environments
SO NUTRITION IN CLINICAL PRACTICE
LA English
DT Article
DE nutritional support; food safety; food contamination; intensive care
units; burns; enteral formulas; enteral nutrition
ID BACTERIAL-CONTAMINATION; BURN PATIENTS; AMBIENT-TEMPERATURE; NUTRITION;
EPIDEMIOLOGY; INJURY; CARE
AB Background: Temperature is known to affect bacterial growth, but current safety recommendations for enteral formula are based on studies conducted in thermoneutral environments, which are not representative of select burn intensive care units (ICUs) that are kept therapeutically hyperthermal. This project evaluated microbial growth in 3 enteral feeding systems: closed, open, and open with modular additives (modular tube feeding [MTF]) exposed to 2 different environments. Procedures: Product for each of the 3 systems was prepared and hung in both a thermoneutral (23.3 degrees C) and a hyperthermal (32.5 degrees C) ICU room. At baseline, 4 hours, and 8 hours, samples were plated and incubated overnight and the number of colony-forming units (CFUs) counted. Findings: In the thermoneutral and hyperthermal environments, there was no evidence of microbial growth in the open or closed feeding systems at any time point. The MTF exhibited baseline contamination with a median of 10 CFUs (95% CI, 8-16) and significant growth over time to 54 CFUs (95% CI, 20-230) by 8 hours in the thermoneutral setting. In the hyperthermal environment, the MTF showed baseline contamination of 390 CFUs (95% CI, 40-1600) and significant growth over time, with 30% of samples exhibiting contamination levels exceeding Food and Drug Administration standards by 4 hours and CFUs being too numerous to count by 8 hours. Conclusion: CFUs in enteral formula did not differ between open and closed feeding systems in either environment for up to 8 hours; however, the addition of modulars to open systems may result in an unacceptable risk of contamination in hyperthermal environments.
C1 [Perry, Jeffery; Stankorb, Susan M.; Salgueiro, Marybeth] Mil Baylor Grad Program Nutr, Jbsa Ft Sam Houston, TX USA.
[Perry, Jeffery; Stankorb, Susan M.; Salgueiro, Marybeth] Brooke Army Med Ctr, San Antonio, TX 78217 USA.
RP Stankorb, SM (reprint author), Brooke Army Med Ctr, 4254 Hilton Head St, San Antonio, TX 78217 USA.
EM susan.stankorb.mil@mail.mil
FU Department of Clinical Investigations, Brooke Army Medical Center
FX This project was funded by the Department of Clinical Investigations,
Brooke Army Medical Center.
NR 27
TC 1
Z9 1
U1 1
U2 4
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0884-5336
EI 1941-2452
J9 NUTR CLIN PRACT
JI Nutr. Clin. Pract.
PD FEB
PY 2015
VL 30
IS 1
BP 128
EP 133
DI 10.1177/0884533614541680
PG 6
WC Nutrition & Dietetics
SC Nutrition & Dietetics
GA AZ7CO
UT WOS:000348376200015
PM 25118176
ER
PT J
AU Scibora, LM
Buchwald, H
Petit, MA
Hughes, J
Ikramuddin, S
AF Scibora, Lesley M.
Buchwald, Henry
Petit, Moira A.
Hughes, Julie
Ikramuddin, Sayeed
TI Bone Strength Is Preserved Following Bariatric Surgery
SO OBESITY SURGERY
LA English
DT Article
DE Bariatric surgery; Morbid obesity; Bone; Bone mineral density; Bone
strength; Peripheral quantitative computed tomography (pQCT)
ID GASTRIC BYPASS-SURGERY; OBESE PREMENOPAUSAL WOMEN; X-RAY ABSORPTIOMETER;
QUALITY-OF-LIFE; WEIGHT-LOSS; BODY-COMPOSITION; FAT MASS;
PHYSICAL-ACTIVITY; MINERAL DENSITY; HIP FRACTURE
AB There is an increasing concern that bariatric surgery results in excessive bone loss as demonstrated by studies that use areal bone mineral density (aBMD) outcomes by dual energy X-ray absorptiometry (DXA). Thus, we explored the effect of bariatric surgery on bone mechanical strength.
Bone strength and body composition outcomes were measured in 21 adults (age 45.3 years; BMI 45.7 kg/m(2)) at baseline (pre-surgery) and 3, 6, and 12 months post-surgery. Bone geometry, density and strength were assessed by peripheral quantitative computed tomography (pQCT) at the distal (4 %) sites of the radius and tibia and at the midshaft sites of the tibia (66 %) and radius (50 %). Participants were divided into tertiles (high, medium, and low) of percentage weight loss at 6 months post-surgery.
Participants in all three tertiles lost significant body weight by 6 months post-surgery (mean loss -5 to -30 %, all p < 0.05). At 6 months, all tertiles lost significant fat mass (-9 to -51 %, all p < 0.05), but only the high tertile lost significant fat-free mass (-8 %, p < 0.05). Despite a slight increase in tibia bone strength (SSIp) at 3 months (+1.1 %, p < 0.05), estimates of bone strength at the radius and tibia sites did not change at later post-surgical time points regardless of weight loss.
Contrary to DXA-based aBMD outcomes in the current literature, these results suggest that bone strength was preserved up to 12 months following bariatric surgery. Future longer-term studies exploring bone strength and geometry are needed to confirm these findings.
C1 [Scibora, Lesley M.] Univ Minnesota, Sch Kinesiol, Minneapolis, MN 55455 USA.
[Buchwald, Henry; Ikramuddin, Sayeed] Univ Minnesota, Dept Surg, VCRC, Minneapolis, MN 55455 USA.
[Petit, Moira A.] Activ8 LLC, St Paul, MN 55105 USA.
[Hughes, Julie] US Army, Inst Environm Med, Mil Performance Div, Natick, MA 01760 USA.
[Scibora, Lesley M.] Univ St Thomas, Hlth & Human Performance Dept, St Paul, MN 55105 USA.
RP Scibora, LM (reprint author), Univ St Thomas, Hlth & Human Performance Dept, 2115 Summit Ave,Mail 4004, St Paul, MN 55105 USA.
EM l.scibora@stthomas.edu; buchw001@umn.edu; moira@activ8-u.com;
julie.m.hughes17.ctr@mail.mil; ikram003@umn.edu
FU Minnesota Obesity Consortium
FX This project was supported by a grant from the Minnesota Obesity
Consortium.
NR 40
TC 1
Z9 1
U1 0
U2 7
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0960-8923
EI 1708-0428
J9 OBES SURG
JI Obes. Surg.
PD FEB
PY 2015
VL 25
IS 2
BP 263
EP 270
DI 10.1007/s11695-014-1341-8
PG 8
WC Surgery
SC Surgery
GA AZ3ER
UT WOS:000348111000010
PM 24972685
ER
PT J
AU Jain, RB
AF Jain, Ram B.
TI Serum cotinine and urinary
4-(methylnitrosamino)-1-(3-pyridyl)-1-butanonol levels among
non-Hispanic Asian American smokers and nonsmokers as compared to other
race/ethnicities: Data from NHANES 2011-2012
SO CHEMOSPHERE
LA English
DT Article
DE Asian American; Race/ethnicity; Second hand smoke; Smoking biomarkers
ID DAILY CIGARETTE SMOKERS; METABOLISM; NICOTINE
AB The objective of this study was to evaluate serum cotinine and total urinary 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanonol (NNAL) levels from a nationally representative sample of non-Hispanic Asian Americans as compared with other racial/ethnic groups. Data from the latest National Health and Nutrition Examination Survey for the years 2011-2012 were used for this purpose. The total sample size used was 4580. Regression models were fitted to estimate serum cotinine and urinary NNAL levels for smokers and nonsmokers aged 20 years and older adjusted for other factors that affect these levels. For nonsmokers, exposure to second hand smoke at home was associated with about 30 times higher serum cotinine levels when compared to those without such exposure (0.717 ng mL(-1) vs. 0.024 ng mL(-1), p < 0.01). NNAL levels among nonsmokers with second hand smoke exposure at home were about twenty times what they were in those without such exposure (9 pg mL(-1) vs. 109 pg mL(-1), p < 0.01). As compared to other racial/ethnic groups, the lowest adjusted serum cotinine levels occurred in non-Hispanic Asian smokers (92.6 ng mL(-1)) and Hispanics (84.5 ng mL(-1)) as compared to non-Hispanic whites (143.8 ng mL(-1)) and non-Hispanic blacks (158.4 ng mL(-1)). Urinary NNAL levels for smokers were in the order: non-Hispanic Asian (0.121 ng mL(-1)) < non-Hispanic blacks (0.139 ng mL(-1)) < Hispanics (0.201 ng mL(-1)) < non-Hispanic whites (0.234 ng mL(-1)). Compared to non-Hispanic whites, non-Hispanic blacks had substantially higher levels of serum cotinine but substantially lower levels of urinary NNAL irrespective of smoking status thus pointing towards differences in elimination kinetics of nicotine/cotinine and NNAL. (C) 2014 Elsevier Ltd. All rights reserved.
C1 [Jain, Ram B.] Womack Army Med Ctr, Ft Bragg, NC 28310 USA.
[Jain, Ram B.] Empiristat Inc, Mt Airy, MD USA.
RP Jain, RB (reprint author), Womack Army Med Ctr, Dept Clin Invest, Ft Bragg, NC 28310 USA.
EM ram.b.jain.ctr@mail.mil
NR 16
TC 4
Z9 4
U1 3
U2 6
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0045-6535
EI 1879-1298
J9 CHEMOSPHERE
JI Chemosphere
PD FEB
PY 2015
VL 120
BP 584
EP 591
DI 10.1016/j.chemosphere.2014.09.069
PG 8
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA AZ1MN
UT WOS:000348003200081
PM 25462301
ER
PT J
AU Klungthong, C
Manasatienkij, W
Phonpakobsin, T
Chinnawirotpisan, P
Rodpradit, P
Hussem, K
Thaisomboonsuk, B
Ong-ajchaowlerd, P
Nisalak, A
Kalayanarooj, S
Buddhari, D
Gibbons, RV
Jarman, RG
Yoon, IK
Fernandez, S
AF Klungthong, Chonticha
Manasatienkij, Wudtichai
Phonpakobsin, Thipwipha
Chinnawirotpisan, Piyawan
Rodpradit, Prinyada
Hussem, Kittinun
Thaisomboonsuk, Butsaya
Ong-ajchaowlerd, Prapapun
Nisalak, Ananda
Kalayanarooj, Siripen
Buddhari, Darunee
Gibbons, Robert V.
Jarman, Richard G.
Yoon, In-Kyu
Fernandez, Stefan
TI Monitoring and improving the sensitivity of dengue nested RT-PCR used in
longitudinal surveillance in Thailand
SO JOURNAL OF CLINICAL VIROLOGY
LA English
DT Article
DE Dengue virus; RT-PCR; Dengue surveillance
ID REVERSE-TRANSCRIPTASE PCR; POLYMERASE-CHAIN-REACTION; VIRUS SEROTYPE 4;
INFECTION; CIRCULATION; BANGKOK; SAMPLES; ASSAY
AB Background: AFRIMS longitudinal dengue surveillance in Thailand depends on the nested RT-PCR and the dengue IgM/IgG ELISA.
Objective: To examine and improve the sensitivity of the nested RT-PCR using a panel of archived samples collected during dengue surveillance.
Study design: A retrospective analysis of 16,454 dengue IgM/IgG ELISA positive cases collected between 2000 and 2013 was done to investigate the sensitivity of the nested RT-PCR. From these cases, 318 acute serum specimens or extracted RNA, previously found to be negative by the nested RT-PCR, were tested using TaqMan real-time RT-PCR (TaqMan rRT-PCR). To improve the sensitivity of nested RT-PCR, we designed a new primer based on nucleotide sequences from contemporary strains found to be positive by the TaqMan rRT-PCR. Sensitivity of the new nested PCR was calculated using a panel of 87 samples collected during 2011-2013.
Results and conclusion: The percentage of dengue IgM/IgG ELISA positive cases that were negative by the nested RT-PCR varied from 17% to 42% for all serotypes depending on the year. Using TaqMan rRT-PCR, dengue RNA was detected in 194 (61%) of the 318 acute sera or extracted RNA previously found to be negative by the nested RT-PCR. The newly designed DENV-1 specific primer increased the sensitivity of DENV-1 detection by the nested RT-PCR from 48% to 88%, and of all 4 serotypes from 73% to 87%. These findings demonstrate the impact of genetic diversity and signal erosion on the sensitivity of PCR-based methods. Published by Elsevier B.V.
C1 [Klungthong, Chonticha; Manasatienkij, Wudtichai; Phonpakobsin, Thipwipha; Chinnawirotpisan, Piyawan; Rodpradit, Prinyada; Hussem, Kittinun; Thaisomboonsuk, Butsaya; Ong-ajchaowlerd, Prapapun; Nisalak, Ananda; Buddhari, Darunee; Yoon, In-Kyu; Fernandez, Stefan] Armed Forces Res Inst Med Sci, Dept Virol, Bangkok 10400, Thailand.
[Kalayanarooj, Siripen] Queen Sin kit Natl Inst Child Hlth, Bangkok, Thailand.
[Jarman, Richard G.] Walter Reed Army Inst Res, Viral Dis Branch, Silver Spring, MD USA.
[Gibbons, Robert V.] US Army Inst Surg Res, JBSA Ft Sam Houston, TX USA.
RP Klungthong, C (reprint author), Armed Forces Res Inst Med Sci, 315-6 Rajvithi Rd, Bangkok 10400, Thailand.
EM Chontichak@afrims.org
FU United States Army Medical Research and Materiel Command (Fort Detrick,
Frederick, MD)
FX This work was supported by the United States Army Medical Research and
Materiel Command (Fort Detrick, Frederick, MD).
NR 32
TC 1
Z9 1
U1 2
U2 4
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1386-6532
EI 1873-5967
J9 J CLIN VIROL
JI J. Clin. Virol.
PD FEB
PY 2015
VL 63
BP 25
EP 31
DI 10.1016/j.jcv.2014.12.009
PG 7
WC Virology
SC Virology
GA AZ2BT
UT WOS:000348040300005
PM 25600599
ER
PT J
AU Johnston, SC
Johnson, JC
Stonier, SW
Lin, KL
Kisalu, NK
Hensley, LE
Rimoin, AW
AF Johnston, Sara C.
Johnson, Joshua C.
Stonier, Spencer W.
Lin, Kenny L.
Kisalu, Neville K.
Hensley, Lisa E.
Rimoin, Anne W.
TI Cytokine modulation correlates with severity of monkeypox disease in
humans
SO JOURNAL OF CLINICAL VIROLOGY
LA English
DT Article
DE Orthopoxvirus; Monkeypox; Cytokine; Cytokine storm; Regulatory T cell
ID REGULATORY T-CELLS; VACCINIA VIRUS-INFECTION; MYASTHENIA-GRAVIS;
SMALLPOX; SUPPRESSION; FOXP3(+); EXPRESSION; EXPANSION; RESPONSES;
INHIBIT
AB Background: Human monkeypox is a zoonotic disease endemic to parts of Africa. Similar to other orthopoxviruses, virus and host have considerable interactions through immunomodulation. These interactions likely drive the establishment of a productive infection and disease progression, resulting in the range of disease presentations and case fatality rates observed for members of the Orthopoxvirus genus.
Objectives: Much of our understanding about the immune response to orthopoxvirus infection comes from either in vitro or in vivo studies performed in small animals or non-human primates. Here, we conducted a detailed assessment of cytokine responses to monkeypox virus using serum from acutely ill humans collected during monkeypox active disease surveillance (2005-2007) in the Democratic Republic of the Congo.
Study design: Nineteen serum samples that were from patients with confirmed monkeypox virus infections were selected for cytokine profiling. Cytokine profiling was performed on the Bio-Rad Bioplex 100 system using a 30-plex human cytokine panel.
Results: Cytokine profiling revealed elevated cytokine concentrations in all samples. Overproduction of certain cytokines (interleukin [IL]-2R, IL-10, and granulocyte macrophage-colony stimulating factor were observed in patients with serious disease (defined as >250 lesions based on the World Health Organization scoring system).
Conclusions: The data suggest that cytokine modulation affects monkeypox disease severity in humans. (C) 2014 Elsevier B.V. All rights reserved.
C1 [Johnston, Sara C.; Johnson, Joshua C.; Stonier, Spencer W.; Lin, Kenny L.; Hensley, Lisa E.] US Army, Med Res Inst Infect Dis, Div Virol, Ft Detrick, MD 21702 USA.
[Kisalu, Neville K.] Univ Calif Los Angeles, Dept Microbiol Immunol & Mol Genet, Los Angeles, CA 90095 USA.
[Rimoin, Anne W.] Univ Calif Los Angeles, Sch Publ Hlth, Dept Epidemiol, Los Angeles, CA 90024 USA.
RP Rimoin, AW (reprint author), 650 Charles E Young Dr South,CHS 71-279B, Los Angeles, CA 90095 USA.
EM arimoin@ucla.edu
OI Johnson, Joshua/0000-0002-5677-3841
FU Defense Threat Reduction Agency [195726]
FX This work was supported by the Defense Threat Reduction Agency [Project
#195726]. Opinions, interpretations, conclusions, and recommendations
are those of the author and are not necessarily endorsed by the U.S.
Army.
NR 24
TC 2
Z9 2
U1 0
U2 5
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1386-6532
EI 1873-5967
J9 J CLIN VIROL
JI J. Clin. Virol.
PD FEB
PY 2015
VL 63
BP 42
EP 45
DI 10.1016/j.jcv.2014.12.001
PG 4
WC Virology
SC Virology
GA AZ2BT
UT WOS:000348040300009
PM 25600603
ER
PT J
AU Jia, ZZ
Sun, J
Dobbs, H
King, J
AF Jia, Zhenzhong
Sun, Jing
Dobbs, Herb
King, Joel
TI Feasibility study of solid oxide fuel cell engines integrated with
sprinter gas turbines: Modeling, design and control
SO JOURNAL OF POWER SOURCES
LA English
DT Article
DE Solid oxide fuel cell (SOFC); Gas turbine (GT); Load following; Design;
Control analysis
ID CONTROL STRATEGY; HYBRID SYSTEMS; POWER-PLANT; PERFORMANCE; OPERATION
AB Conventional recuperating solid oxide fuel cell (SOFC)/gas turbine (GT) system suffers from its poor dynamic capability and load following performance. To meet the fast, safe and efficient load following requirements for mobile applications, a sprinter SOFC/GT system concept is proposed in this paper. In the proposed system, an SOFC stack operating at fairly constant temperature provides the baseline power with high efficiency while the fast dynamic capability of the GT-generator is fully explored for fast dynamic load following. System design and control studies have been conducted by using an SOFC/GT system model consisting of experimentally-verified component models. In particular, through analysis of the steady-state simulation results, an SOFC operation strategy is proposed to maintain fairly constant SOFC power (less than 2% power variation) and temperature (less than 2 K temperature variation) over the entire load range. A system design procedure well-suited to the proposed system has also been developed to help determining component sizes and the reference steady-state operation line. In addition, control analysis has been studied for both steady-state and transient operations. Simulation results suggest that the proposed system holds the promise to achieve fast and safe transient operations by taking full advantage of the fast dynamics of the GT-generator. (C) 2014 Elsevier B.V. All rights reserved.
C1 [Jia, Zhenzhong; Sun, Jing] Univ Michigan, Dept Naval Architecture & Marine Engn NAME, Ann Arbor, MI 48109 USA.
[Dobbs, Herb; King, Joel] US Army TARDEC, Nonprimary Power Syst Team, Warren, MI 48397 USA.
RP Jia, ZZ (reprint author), Univ Michigan, Dept Naval Architecture & Marine Engn NAME, Ann Arbor, MI 48109 USA.
EM zhenzjia@umich.edu; jingsun@umich.edu
FU Automotive Research Center (US Army TARDEC)
FX The authors would like to acknowledge the Automotive Research Center (US
Army TARDEC) for the support of this research.
NR 39
TC 4
Z9 4
U1 0
U2 20
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-7753
EI 1873-2755
J9 J POWER SOURCES
JI J. Power Sources
PD FEB 1
PY 2015
VL 275
BP 111
EP 125
DI 10.1016/j.jpowsour.2014.10.203
PG 15
WC Chemistry, Physical; Electrochemistry; Energy & Fuels; Materials
Science, Multidisciplinary
SC Chemistry; Electrochemistry; Energy & Fuels; Materials Science
GA AZ2UT
UT WOS:000348088400017
ER
PT J
AU Taylor, S
Bigl, S
Packer, B
AF Taylor, Susan
Bigl, Susan
Packer, Bonnie
TI Condition of in situ unexploded ordnance
SO SCIENCE OF THE TOTAL ENVIRONMENT
LA English
DT Article
DE Unexploded ordnance; Explosives; Soil sampling; Pitting corrosion;
Oxidation
ID RANGES
AB Unexploded ordnance (UXO) become point contamination sources when their casings fail and their explosive fill dissolve. To determine the modes of failure, we documented the condition of UXO found on military training ranges and sampled soils for explosives beneath 42 in situ UXO. We found that oxidation caused the metal UXO casings to swell and fail catastrophically. Unlike previous work, pitting of the metal casings was not found to be an important release route for explosives. Of the 42 UXO sampled, eight were leaking explosives into the soil and of these, four had perforated or cracked casings, three were corroded and one was a partially detonated round. We estimated a surface density of 74 UXO per hectare for a subset of UXO sampled. We used the relative concentrations of explosives and their transformation products in the soil to determine if the explosives had recently dissolved or were from past military training. Published by Elsevier B.V.
C1 [Taylor, Susan; Bigl, Susan] US Army, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA.
[Packer, Bonnie] ARNG ILE C, Arlington, VA 22204 USA.
RP Taylor, S (reprint author), US Army, Cold Reg Res & Engn Lab, 72 Lyme Rd, Hanover, NH 03755 USA.
EM Susan.Taylor@usace.army.mil
FU U.S. Army Environmental Command; CH2MHill Inc.
FX The authors thank the U.S. Army Environmental Command for funding this
work and Kim Watts the project managers. We thank Jim Hug and
Christopher Graber, our unexploded ordnance team, for keeping us safe.
Thanks to Michael and Marianne Walsh for suggesting sampling locations
in Alaska. We appreciate the support provided by personnel with CH2MHill
Inc., responsible for remediating the Vieques Naval Training Range, in
particular Philip Fitzwater, Tim Garretson, and Billy Capstick. We thank
Madeline Riviera, the Navy coordinator at Vieques, for providing access
to range records and Jae Yun, the Parsons site manager who helped us
with access to the San Luis Obispo, CA site. Finally, this paper was
substantially improved by the comments provided to us by three anonymous
reviewers.
NR 21
TC 3
Z9 3
U1 0
U2 7
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0048-9697
EI 1879-1026
J9 SCI TOTAL ENVIRON
JI Sci. Total Environ.
PD FEB 1
PY 2015
VL 505
BP 762
EP 769
DI 10.1016/j.scitotenv.2014.10.059
PG 8
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA AY6CJ
UT WOS:000347654900077
PM 25461079
ER
PT J
AU Boedihardjo, AP
Lu, CT
Chen, F
AF Boedihardjo, Arnold P.
Lu, Chang-Tien
Chen, Feng
TI Fast adaptive kernel density estimator for data streams
SO KNOWLEDGE AND INFORMATION SYSTEMS
LA English
DT Article
DE Data mining; Data streams; Kernel density estimation
AB The probability density function (PDF) is an effective data model for a variety of stream mining tasks. As such, accurate estimates of the PDF are essential to reducing the uncertainties and errors associated with mining results. The nonparametric adaptive kernel density estimator (AKDE) provides accurate, robust, and asymptotically consistent estimates of a PDF. However, due to AKDE's extensive computational requirements, it cannot be directly applied to the data stream environment. This paper describes the development of an AKDE approximation approach that heeds the constraints of the data stream environment and supports efficient processing of multiple queries. To this end, this work proposes (1) the concept of local regions to provide a partition-based variable bandwidth to capture local density structures and enhance estimation quality; (2) a suite of linear-pass methods to construct the local regions and kernel objects online; (3) an efficient multiple queries evaluation algorithm; (4) a set of approximate techniques to increase the throughput of multiple density queries processing; and (5) a fixed-size memory time-based sliding window that updates the kernel objects in linear time. Comprehensive experiments were conducted with real-world and synthetic data sets to validate the effectiveness and efficiency of the approach.
C1 [Boedihardjo, Arnold P.] US Army Corps Engineers, Alexandria, VA 22315 USA.
[Lu, Chang-Tien] Virginia Tech, Dept Comp Sci, Falls Church, VA USA.
[Chen, Feng] Carnegie Melon Univ, Dept Comp Sci, Pittsburgh, PA USA.
RP Boedihardjo, AP (reprint author), US Army Corps Engineers, Alexandria, VA 22315 USA.
EM arnold.p.boedihardjo@usace.army.mil; ctlu@vt.edu; fchen1@andrew.cmu.edu
NR 35
TC 1
Z9 1
U1 0
U2 11
PU SPRINGER LONDON LTD
PI LONDON
PA 236 GRAYS INN RD, 6TH FLOOR, LONDON WC1X 8HL, ENGLAND
SN 0219-1377
EI 0219-3116
J9 KNOWL INF SYST
JI Knowl. Inf. Syst.
PD FEB
PY 2015
VL 42
IS 2
BP 285
EP 317
DI 10.1007/s10115-013-0712-0
PG 33
WC Computer Science, Artificial Intelligence; Computer Science, Information
Systems
SC Computer Science
GA AY8AH
UT WOS:000347776300002
ER
PT J
AU Prager, EM
Figueiredo, TH
Long, RP
Aroniadou-Anderjaska, V
Apland, JP
Braga, MFM
AF Prager, Eric M.
Figueiredo, Taiza H.
Long, Robert P., II
Aroniadou-Anderjaska, Vassiliki
Apland, James P.
Braga, Maria F. M.
TI LY293558 prevents soman-induced pathophysiological alterations in the
basolateral amygdala and the development of anxiety
SO NEUROPHARMACOLOGY
LA English
DT Article
DE Soman; LY293558; Basolateral amygdala; Anxiety; Long-term potentiation;
Paired-pulse ratio
ID POSTTRAUMATIC-STRESS-DISORDER; ORGANOPHOSPHORUS NERVE AGENTS; RECEPTOR
ANTAGONIST LY293558; INDUCED SEIZURE ACTIVITY; LONG-TERM POTENTIATION;
STATUS EPILEPTICUS; GABA(A) RECEPTORS; ACOUSTIC STARTLE;
ELECTRICAL-STIMULATION; KAINATE RECEPTORS
AB Exposure to nerve agents can cause brain damage due to prolonged seizure activity, producing long-term behavioral deficits. We have previously shown that LY293558, a GluK1/AMPA receptor antagonist, is a very effective anticonvulsant and neuroprotectant against nerve agent exposure. In the present study, we examined whether the protection against nerve agent-induced seizures and neuropathology conferred by LY293558 translates into protection against pathophysiological alterations in the basolateral amygdala (BLA) and the development of anxiety, which is the most prevalent behavioral deficit resulting from exposure. LY293558 (15 mg/1