FN Thomson Reuters Web of Science™
VR 1.0
PT J
AU Borodin, O
Olguin, M
Jow, TR
Spear, C
Knap, J
Leiter, K
AF Borodin, Oleg
Olguin, Marco
Jow, T. Richard
Spear, Carrie
Knap, Jaroslaw
Leiter, Kenneth
TI Oxidation stability and decomposition reactions of battery electrolytes
and additives in bulk and at interfaces
SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
LA English
DT Meeting Abstract
CT 248th National Meeting of the American-Chemical-Society (ACS)
CY AUG 10-14, 2014
CL San Francisco, CA
SP Amer Chem Soc
C1 [Borodin, Oleg; Olguin, Marco; Jow, T. Richard] Army Res Lab, Adelphi, MD 20789 USA.
[Spear, Carrie; Knap, Jaroslaw; Leiter, Kenneth] US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA.
EM olegutah@gmail.com
RI Borodin, Oleg/B-6855-2012
OI Borodin, Oleg/0000-0002-9428-5291
NR 0
TC 0
Z9 0
U1 0
U2 2
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0065-7727
J9 ABSTR PAP AM CHEM S
JI Abstr. Pap. Am. Chem. Soc.
PD AUG 10
PY 2014
VL 248
MA 130-COMP
PG 1
WC Chemistry, Multidisciplinary
SC Chemistry
GA CA8JN
UT WOS:000349165104369
ER
PT J
AU Chudomel, JM
Shi, JM
Forsythe, EW
AF Chudomel, J. Matthew
Shi, Jianmin
Forsythe, Eric W.
TI Synthesis of a class of efficient blue photoluminescent molecules based
on a benzotriimidazole core
SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
LA English
DT Meeting Abstract
CT 248th National Meeting of the American-Chemical-Society (ACS)
CY AUG 10-14, 2014
CL San Francisco, CA
SP Amer Chem Soc
C1 [Chudomel, J. Matthew; Shi, Jianmin; Forsythe, Eric W.] US Army Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA.
EM jchudome@gmail.com
NR 0
TC 0
Z9 0
U1 1
U2 2
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0065-7727
J9 ABSTR PAP AM CHEM S
JI Abstr. Pap. Am. Chem. Soc.
PD AUG 10
PY 2014
VL 248
MA 830-ORGN
PG 1
WC Chemistry, Multidisciplinary
SC Chemistry
GA CA8KC
UT WOS:000349167403395
ER
PT J
AU Garcia-Reyero, N
Habib, T
Villeneuve, D
Escalon, L
Ankley, G
Perkins, E
AF Garcia-Reyero, Natalia
Habib, Tanwir
Villeneuve, Daniel
Escalon, Lynn
Ankley, Gerald
Perkins, Edward
TI Systems approach to detect and evaluate contaminants of emerging concern
in the Great Lakes
SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
LA English
DT Meeting Abstract
CT 248th National Meeting of the American-Chemical-Society (ACS)
CY AUG 10-14, 2014
CL San Francisco, CA
SP Amer Chem Soc
C1 [Garcia-Reyero, Natalia] Mississippi State Univ, Inst Genom Biocomp & Biotechnol, Starkville, MS 39759 USA.
[Habib, Tanwir] Badger Tech Serv, San Antonio, TX USA.
[Villeneuve, Daniel; Ankley, Gerald] US EPA, Natl Hlth & Environm Effects Res Lab, Duluth, MN USA.
[Escalon, Lynn; Perkins, Edward] US Army Engn Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA.
EM nvinas@igbb.msstate.edu
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0065-7727
J9 ABSTR PAP AM CHEM S
JI Abstr. Pap. Am. Chem. Soc.
PD AUG 10
PY 2014
VL 248
MA 9-ENVR
PG 1
WC Chemistry, Multidisciplinary
SC Chemistry
GA CA8JN
UT WOS:000349165105454
ER
PT J
AU Golius, A
Isayev, O
Gorb, L
Hill, FC
Leszczynski, J
AF Golius, Anastasiia
Isayev, Olexander
Gorb, Leonid
Hill, Frances C.
Leszczynski, Jerzy
TI Energetic compounds as environmental contaminants: Theoretical studies
SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
LA English
DT Meeting Abstract
CT 248th National Meeting of the American-Chemical-Society (ACS)
CY AUG 10-14, 2014
CL San Francisco, CA
SP Amer Chem Soc
C1 [Golius, Anastasiia; Leszczynski, Jerzy] Jackson State Univ, Dept Chem & Biochem, Jackson, MS 39217 USA.
[Isayev, Olexander] Univ N Carolina, UNC Eshelman Sch Pharm, Div Chem Biol & Med Chem, Chapel Hill, NC USA.
[Gorb, Leonid] Badger Tech Serv LLC, Vicksburg, MS USA.
[Hill, Frances C.] US Army Engineer Res & Dev Ctr, Vicksburg, MS USA.
EM anastasia@icnanotox.org
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0065-7727
J9 ABSTR PAP AM CHEM S
JI Abstr. Pap. Am. Chem. Soc.
PD AUG 10
PY 2014
VL 248
MA 118-TOXI
PG 1
WC Chemistry, Multidisciplinary
SC Chemistry
GA CA8KC
UT WOS:000349167406270
ER
PT J
AU Haskins, J
Bennett, WR
Hernandez-Lugo, DM
Wu, J
Borodin, O
Monk, JD
Bauschlicher, CW
Lawson, J
AF Haskins, Justin
Bennett, William R.
Hernandez-Lugo, Dione M.
Wu, James
Borodin, Oleg
Monk, Joshua D.
Bauschlicher, Charles W.
Lawson, John
TI Investigation of structure and transport in Li-doped ionic liquid
electrolytes: [pyr14][TFSI], [pyr13][FSI], and [EMIM][BF4]
SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
LA English
DT Meeting Abstract
CT 248th National Meeting of the American-Chemical-Society (ACS)
CY AUG 10-14, 2014
CL San Francisco, CA
SP Amer Chem Soc
C1 [Haskins, Justin; Monk, Joshua D.; Bauschlicher, Charles W.; Lawson, John] NASA, Ames Res Ctr, Moffett Field, CA 94035 USA.
[Bennett, William R.; Hernandez-Lugo, Dione M.; Wu, James] NASA, Glenn Res Ctr, Cleveland, OH 44135 USA.
[Borodin, Oleg] US Army Res Lab, Adelphi, MD 20783 USA.
EM justin.b.haskins@nasa.gov
RI Borodin, Oleg/B-6855-2012
OI Borodin, Oleg/0000-0002-9428-5291
NR 0
TC 0
Z9 0
U1 1
U2 3
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0065-7727
J9 ABSTR PAP AM CHEM S
JI Abstr. Pap. Am. Chem. Soc.
PD AUG 10
PY 2014
VL 248
MA 629-PHYS
PG 1
WC Chemistry, Multidisciplinary
SC Chemistry
GA CA8KC
UT WOS:000349167404333
ER
PT J
AU Hu, FS
LaScala, J
Sadler, J
Palmese, G
AF Hu, Fengshuo
LaScala, John
Sadler, Joshua
Palmese, Giuseppe
TI Synthesis and characterization of thermosetting furan-based epoxy
systems
SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
LA English
DT Meeting Abstract
CT 248th National Meeting of the American-Chemical-Society (ACS)
CY AUG 10-14, 2014
CL San Francisco, CA
SP Amer Chem Soc
C1 [Hu, Fengshuo; Palmese, Giuseppe] Drexel Univ, Dept Chem & Biol Engn, Philadelphia, PA 19104 USA.
[LaScala, John; Sadler, Joshua] Army Res Labs, Aberdeen Proving Ground, MD 21005 USA.
EM fh83@drexel.edu
NR 0
TC 0
Z9 0
U1 4
U2 4
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0065-7727
J9 ABSTR PAP AM CHEM S
JI Abstr. Pap. Am. Chem. Soc.
PD AUG 10
PY 2014
VL 248
MA 742-POLY
PG 1
WC Chemistry, Multidisciplinary
SC Chemistry
GA CA8KC
UT WOS:000349167406031
ER
PT J
AU Lambeth, RH
Jackson, A
Beyer, F
AF Lambeth, Robert H.
Jackson, Aaron
Beyer, Frederick
TI Model metallo-supramolecular crosslinked polymers with tunable
properties
SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
LA English
DT Meeting Abstract
CT 248th National Meeting of the American-Chemical-Society (ACS)
CY AUG 10-14, 2014
CL San Francisco, CA
SP Amer Chem Soc
C1 [Lambeth, Robert H.; Jackson, Aaron; Beyer, Frederick] ARL, Aberdeen Proving Ground, MD 21921 USA.
EM robert.h.lambeth2.civ@mail.mil
NR 0
TC 0
Z9 0
U1 1
U2 1
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0065-7727
J9 ABSTR PAP AM CHEM S
JI Abstr. Pap. Am. Chem. Soc.
PD AUG 10
PY 2014
VL 248
MA 46-POLY
PG 1
WC Chemistry, Multidisciplinary
SC Chemistry
GA CA8KC
UT WOS:000349167405182
ER
PT J
AU O'Neil, J
Lewis, EA
Lum, JS
AF O'Neil, Jacklyn
Lewis, Emily A.
Lum, June S.
TI Increased participation of younger chemists into YCC and Northeastern
Section activities and the tangential opportunity for chemistry
education
SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
LA English
DT Meeting Abstract
CT 248th National Meeting of the American-Chemical-Society (ACS)
CY AUG 10-14, 2014
CL San Francisco, CA
SP Amer Chem Soc
C1 [O'Neil, Jacklyn] Alkermes, Dept Pharmaceut Chem & Formulat, Waltham, MA 02451 USA.
[Lewis, Emily A.] Tufts Univ, Dept Chem, Medford, MA 02155 USA.
[Lum, June S.] US Army Natick Soldier Res, Ctr Dev & Engn, Natick, MA 01760 USA.
[O'Neil, Jacklyn; Lewis, Emily A.; Lum, June S.] Northeastern Sect Younger Chem Comm, Boston, MA USA.
EM jacklyn.oneil@alkermes.com
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0065-7727
J9 ABSTR PAP AM CHEM S
JI Abstr. Pap. Am. Chem. Soc.
PD AUG 10
PY 2014
VL 248
MA 113-CHED
PG 1
WC Chemistry, Multidisciplinary
SC Chemistry
GA CA8JN
UT WOS:000349165102763
ER
PT J
AU Perkins, EJ
Habib, T
Escalon, L
Villenueve, DL
Ankley, GT
Garcia-Reyero, N
AF Perkins, Edward J.
Habib, Tanwir
Escalon, Lynn
Villenueve, Daniel L.
Ankley, Gerald T.
Garcia-Reyero, Natalia
TI Inference of chemicals that cause biological effects in treated pulp and
paper mill effluent using gene expression in caged fathead minnows
SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
LA English
DT Meeting Abstract
CT 248th National Meeting of the American-Chemical-Society (ACS)
CY AUG 10-14, 2014
CL San Francisco, CA
SP Amer Chem Soc
C1 [Perkins, Edward J.; Escalon, Lynn] US Army Engn Res & Dev Ctr, Vicksburg, MS 39180 USA.
[Habib, Tanwir] Badger Tech Serv, San Antonio, TX 78216 USA.
[Villenueve, Daniel L.; Ankley, Gerald T.] US EPA, Natl Hlth & Environm Effects Res Lab, Duluth, MN 55802 USA.
[Garcia-Reyero, Natalia] Mississippi State Univ, Gen Biocomp & Biotechnol 1Inst, Starkville, MS 39762 USA.
EM edward.j.perkins@usace.army.mil
NR 0
TC 0
Z9 0
U1 1
U2 3
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0065-7727
J9 ABSTR PAP AM CHEM S
JI Abstr. Pap. Am. Chem. Soc.
PD AUG 10
PY 2014
VL 248
MA 7-ENVR
PG 1
WC Chemistry, Multidisciplinary
SC Chemistry
GA CA8JN
UT WOS:000349165105452
ER
PT J
AU Peterson, GW
DeCoste, JB
AF Peterson, Gregory W.
DeCoste, Jared B.
TI Mesoporosity development in Zr-based metal-organic frameworks via plasma
etching
SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
LA English
DT Meeting Abstract
CT 248th National Meeting of the American-Chemical-Society (ACS)
CY AUG 10-14, 2014
CL San Francisco, CA
SP Amer Chem Soc
C1 [Peterson, Gregory W.] US Army, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA.
[DeCoste, Jared B.] Leidos Inc, Gundpowder, MD 21010 USA.
EM gregory.w.peterson.civ@mail.mil
NR 0
TC 0
Z9 0
U1 1
U2 1
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0065-7727
J9 ABSTR PAP AM CHEM S
JI Abstr. Pap. Am. Chem. Soc.
PD AUG 10
PY 2014
VL 248
MA 442-INOR
PG 1
WC Chemistry, Multidisciplinary
SC Chemistry
GA CA8KC
UT WOS:000349167401105
ER
PT J
AU Schroeder, A
Ankley, G
Berninger, J
LaLone, C
Cavallin, J
Durhan, E
Eid, E
Garcia-Reyero, N
Hughes, M
Jensen, K
Kahl, M
Makynen, E
Perkins, E
Stevens, K
Villeneuve, D
AF Schroeder, Anthony
Ankley, Gerald
Berninger, Jason
LaLone, Carlie
Cavallin, Jenna
Durhan, Elizabeth
Eid, Evan
Garcia-Reyero, Natalia
Hughes, Megan
Jensen, Kathy
Kahl, Michael
Makynen, Elizabeth
Perkins, Ed
Stevens, Kyle
Villeneuve, Dan
TI Integration of analytical and biological measurements for assessing the
effects of contaminants present at Great Lakes areas of concern
SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
LA English
DT Meeting Abstract
CT 248th National Meeting of the American-Chemical-Society (ACS)
CY AUG 10-14, 2014
CL San Francisco, CA
SP Amer Chem Soc
C1 [Schroeder, Anthony; LaLone, Carlie] Univ Minnesota, Water Resources Ctr, St Paul, MN 55108 USA.
[Schroeder, Anthony; Ankley, Gerald; LaLone, Carlie; Durhan, Elizabeth; Eid, Evan; Hughes, Megan; Jensen, Kathy; Kahl, Michael; Makynen, Elizabeth; Villeneuve, Dan] US EPA, Midcontinent Ecol Div, Duluth, MN 55804 USA.
[Garcia-Reyero, Natalia] Mississippi State Univ, Inst Genom Biocomp & Biotechnol, Starkville, MS USA.
[Perkins, Ed] US Army Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS USA.
EM schroeder.anthony@epa.gov
RI Berninger, Jason/O-2401-2016
OI Berninger, Jason/0000-0003-3045-7899
NR 0
TC 0
Z9 0
U1 0
U2 3
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0065-7727
J9 ABSTR PAP AM CHEM S
JI Abstr. Pap. Am. Chem. Soc.
PD AUG 10
PY 2014
VL 248
MA 668-ENVR
PG 1
WC Chemistry, Multidisciplinary
SC Chemistry
GA CA8JN
UT WOS:000349165106211
ER
PT J
AU Siraj, N
Das, S
Hasan, FS
Kiruri, LW
Gall, KES
Warner, IM
AF Siraj, Noureen
Das, Susmita
Hasan, Farhana S.
Kiruri, Lucy W.
Gall, Karen E. Steege
Warner, Isiah M.
TI Anomalous S-2 emission from carbazole-based GUMBOS
SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
LA English
DT Meeting Abstract
CT 248th National Meeting of the American-Chemical-Society (ACS)
CY AUG 10-14, 2014
CL San Francisco, CA
SP Amer Chem Soc
C1 [Siraj, Noureen; Das, Susmita; Hasan, Farhana S.; Kiruri, Lucy W.; Warner, Isiah M.] Louisiana State Univ, Baton Rouge, LA 70803 USA.
[Gall, Karen E. Steege] USA, HORIBA Sci, Philadelphia, PA 08820 USA.
EM nsiraj@lsu.edu
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0065-7727
J9 ABSTR PAP AM CHEM S
JI Abstr. Pap. Am. Chem. Soc.
PD AUG 10
PY 2014
VL 248
MA 61-PHYS
PG 1
WC Chemistry, Multidisciplinary
SC Chemistry
GA CA8KC
UT WOS:000349167403666
ER
PT J
AU Thompson, T
Wolfenstine, J
Allen, J
Johannes, M
Huq, A
Sakamoto, J
AF Thompson, Travis
Wolfenstine, Jeff
Allen, Jan
Johannes, Michelle
Huq, Ashfia
Sakamoto, Jeff
TI Tetragonal vs. cubic phase stability in Al - free Ta doped Li7La3Zr2O12
garnet Li ion solid electrolyte
SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
LA English
DT Meeting Abstract
CT 248th National Meeting of the American-Chemical-Society (ACS)
CY AUG 10-14, 2014
CL San Francisco, CA
SP Amer Chem Soc
C1 [Thompson, Travis; Sakamoto, Jeff] Michigan State Univ, Dept Chem Engn & Mat Sci, E Lansing, MI 48824 USA.
[Wolfenstine, Jeff; Allen, Jan] Army Res Lab, RDRL SED C, Adelphi, MD 20783 USA.
[Johannes, Michelle] Naval Res Lab, Ctr Computat Mat Sci, Anacostia, VA USA.
[Huq, Ashfia] Oak Ridge Natl Lab, Spallat Neutron Source, Oak Ridge, TN USA.
EM trthompson378@gmail.com
NR 0
TC 0
Z9 0
U1 2
U2 4
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0065-7727
J9 ABSTR PAP AM CHEM S
JI Abstr. Pap. Am. Chem. Soc.
PD AUG 10
PY 2014
VL 248
MA 561-ENFL
PG 1
WC Chemistry, Multidisciplinary
SC Chemistry
GA CA8JN
UT WOS:000349165105368
ER
PT J
AU Torres, OB
Jalah, R
Rice, KC
Li, FY
Antoline, JFG
Iyer, MR
Cheng, KJ
Jacobson, AE
Beck, Z
Alving, CR
Matyas, GR
AF Torres, Oscar B.
Jalah, Rashmi
Rice, Kenner C.
Li, Fuying
Antoline, Joshua F. G.
Iyer, Malliga R.
Cheng, Kejun
Jacobson, Arthur E.
Beck, Zoltan
Alving, Carl R.
Matyas, Gary R.
TI Development of a vaccine for the treatment of heroin addiction:
Determination of the optimal heroin hapten-carrier density
SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
LA English
DT Meeting Abstract
CT 248th National Meeting of the American-Chemical-Society (ACS)
CY AUG 10-14, 2014
CL San Francisco, CA
SP Amer Chem Soc
C1 [Torres, Oscar B.; Jalah, Rashmi; Beck, Zoltan; Alving, Carl R.; Matyas, Gary R.] US Mil HIV Res Program, Walter Reed Army Inst Res, Lab Adjuvant & Antigen Res, Silver Spring, MD 20910 USA.
[Rice, Kenner C.; Li, Fuying; Antoline, Joshua F. G.; Cheng, Kejun; Jacobson, Arthur E.] NIDA, Dept Hlth & Human Serv, Drug Design & Synth Sect, Chem Biol Res Branch, Bethesda, MD 20892 USA.
[Rice, Kenner C.; Li, Fuying; Antoline, Joshua F. G.; Iyer, Malliga R.; Cheng, Kejun; Jacobson, Arthur E.] NIAAA, NIH, Bethesda, MD 20892 USA.
[Torres, Oscar B.; Jalah, Rashmi; Beck, Zoltan] US Mil HIV Res Program, Henry M Jackson Fdn Adv Mil Med, Bethesda, MD 20817 USA.
EM otorres@hivresearch.org
NR 0
TC 0
Z9 0
U1 0
U2 1
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0065-7727
J9 ABSTR PAP AM CHEM S
JI Abstr. Pap. Am. Chem. Soc.
PD AUG 10
PY 2014
VL 248
MA 428-MEDI
PG 1
WC Chemistry, Multidisciplinary
SC Chemistry
GA CA8KC
UT WOS:000349167402224
ER
PT J
AU Tran, DT
Rong, C
AF Tran, Dat T.
Rong, Charles
TI Desulfurization of H2S using porous ZnO-based materials as sorbents
SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
LA English
DT Meeting Abstract
CT 248th National Meeting of the American-Chemical-Society (ACS)
CY AUG 10-14, 2014
CL San Francisco, CA
SP Amer Chem Soc
C1 [Tran, Dat T.; Rong, Charles] US Army Res Lab, Sensor & Electron Devices Directorate, Adelphi, MD 20783 USA.
EM dat.t.tran4.civ@mail.mil
NR 0
TC 0
Z9 0
U1 0
U2 1
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0065-7727
J9 ABSTR PAP AM CHEM S
JI Abstr. Pap. Am. Chem. Soc.
PD AUG 10
PY 2014
VL 248
MA 306-ENFL
PG 1
WC Chemistry, Multidisciplinary
SC Chemistry
GA CA8JN
UT WOS:000349165105144
ER
PT J
AU Taylor, DE
AF Taylor, DeCarlos E.
TI Pressure dependent elastic constants of alpha and gamma
cyclotrimethylene trinitramine: A quantum mechanical study
SO JOURNAL OF APPLIED PHYSICS
LA English
DT Article
ID SOLID NITROMETHANE; CRYSTAL-STRUCTURE; MONTE-CARLO; RDX; SIMULATIONS;
STRAIN; HMX
AB The elastic constants of the alpha and gamma polymorphs of cyclotrimethylene trinitramine (RDX) have been computed using dispersion corrected density functional theory (DFT). The DFT results validate the values obtained in several experiments using ultrasonic and impulsive stimulated thermal scattering techniques and disagree with those obtained using Brillouin scattering which, in general, exceed the other experimental and theoretical results. Compressibility diagrams at zero pressure are presented for the ab, ac, and bc crystallographic planes, and the anisotropic linear compressibility within the ac plane of alpha-RDX at 0 GPa, observed using ultrasonic and impulsive stimulated thermal scattering measurements, is verified using DFT. The pressure dependence of the elastic constants of alpha-RDX (0-4 GPa) and gamma-RDX (4-8 GPa) is also presented.
C1 US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA.
RP Taylor, DE (reprint author), US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA.
EM decarlos.e.taylor.civ@mail.mil
NR 29
TC 8
Z9 8
U1 2
U2 22
PU AMER INST PHYSICS
PI MELVILLE
PA 1305 WALT WHITMAN RD, STE 300, MELVILLE, NY 11747-4501 USA
SN 0021-8979
EI 1089-7550
J9 J APPL PHYS
JI J. Appl. Phys.
PD AUG 7
PY 2014
VL 116
IS 5
AR 053513
DI 10.1063/1.4891999
PG 9
WC Physics, Applied
SC Physics
GA AO2TM
UT WOS:000341178900021
ER
PT J
AU Whitney, JB
Hill, AL
Sanisetty, S
Penaloza-MacMaster, P
Liu, JY
Shetty, M
Parenteau, L
Cabral, C
Shields, J
Blackmore, S
Smith, JY
Brinkman, AL
Peter, LE
Mathew, SI
Smith, KM
Borducchi, EN
Rosenbloom, DIS
Lewis, MG
Hattersley, J
Li, B
Hesselgesser, J
Geleziunas, R
Robb, ML
Kim, JH
Michael, NL
Barouch, DH
AF Whitney, James B.
Hill, Alison L.
Sanisetty, Srisowmya
Penaloza-MacMaster, Pablo
Liu, Jinyan
Shetty, Mayuri
Parenteau, Lily
Cabral, Crystal
Shields, Jennifer
Blackmore, Stephen
Smith, Jeffrey Y.
Brinkman, Amanda L.
Peter, Lauren E.
Mathew, Sheeba I.
Smith, Kaitlin M.
Borducchi, Erica N.
Rosenbloom, Daniel I. S.
Lewis, Mark G.
Hattersley, Jillian
Li, Bei
Hesselgesser, Joseph
Geleziunas, Romas
Robb, Merlin L.
Kim, Jerome H.
Michael, Nelson L.
Barouch, Dan H.
TI Rapid seeding of the viral reservoir prior to SIV viraemia in rhesus
monkeys
SO NATURE
LA English
DT Article
ID IMMUNODEFICIENCY VIRUS-INFECTION; ACTIVE ANTIRETROVIRAL THERAPY; HIV-1
INFECTION; LATENT INFECTION; REPLICATION; VACCINE; PREVENTION;
INITIATION; DYNAMICS; DEPENDS
AB The viral reservoir represents a critical challenge for human immunodeficiency virus type 1 (HIV-1) eradication strategies(1-5). However, it remains unclear when and where the viral reservoir is seeded during acute infection and the extent to which it is susceptible to early anti-retroviral therapy (ART). Here we show that the viral reservoir is seeded rapidly after mucosal simian immunodeficiency virus (SIV) infection of rhesus monkeys and before systemic viraemia. We initiated suppressive ART in groups of monkeys on days 3, 7, 10 and 14 after intrarectal SIVMAC251 infection. Treatment with ART on day 3 blocked the emergence of viral RNA and proviral DNA in peripheral blood and also substantially reduced levels of proviral DNA in lymph nodes and gastrointestinal mucosa as compared with treatment at later time points. In addition, treatment on day 3 abrogated the induction of SIV-specific humoral and cellular immune responses. Nevertheless, after discontinuation of ART following 24 weeks of fully suppressive therapy, virus rebounded in all animals, although the monkeys that were treated on day 3 exhibited a delayed viral rebound as compared with those treated on days 7, 10 and 14. The time to viral rebound correlated with total viraemia during acute infection and with proviral DNA at the time of ART discontinuation. These data demonstrate that the viral reservoir is seeded rapidly after intrarectal SIV infection of rhesus monkeys, during the 'eclipse' phase, and before detectable viraemia. This strikingly early seeding of the refractory viral reservoir raises important new challenges for HIV-1 eradication strategies.
C1 [Whitney, James B.; Sanisetty, Srisowmya; Penaloza-MacMaster, Pablo; Liu, Jinyan; Shetty, Mayuri; Parenteau, Lily; Cabral, Crystal; Shields, Jennifer; Blackmore, Stephen; Smith, Jeffrey Y.; Brinkman, Amanda L.; Peter, Lauren E.; Mathew, Sheeba I.; Smith, Kaitlin M.; Borducchi, Erica N.; Barouch, Dan H.] Harvard Univ, Beth Israel Deaconess Med Ctr, Sch Med, Ctr Virol & Vaccine Res, Boston, MA 02215 USA.
[Whitney, James B.; Barouch, Dan H.] Ragon Inst MGH MIT & Harvard, Cambridge, MA 02139 USA.
[Hill, Alison L.; Rosenbloom, Daniel I. S.] Harvard Univ, Program Evolutionary Dynam, Cambridge, MA 02138 USA.
[Lewis, Mark G.] Bioqual, Rockville, MD 20852 USA.
[Hattersley, Jillian; Li, Bei; Hesselgesser, Joseph; Geleziunas, Romas] Gilead Sci Inc, Foster City, CA 94404 USA.
[Robb, Merlin L.; Kim, Jerome H.; Michael, Nelson L.] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD 20910 USA.
RP Barouch, DH (reprint author), Harvard Univ, Beth Israel Deaconess Med Ctr, Sch Med, Ctr Virol & Vaccine Res, Boston, MA 02215 USA.
EM dbarouch@bidmc.harvard.edu
FU US Army Medical Research and Material Command; US Military HIV Research
Program; Henry M. Jackson Foundation for the Advancement of Military
Medicine [W81XWH-07-2-0067, W81XWH-11-2-0174]; NIH [AI060354, AI078526,
AI084794, AI095985, AI096040, AI100645]; Ragon Institute of MGH, MIT and
Harvard
FX We thank M. Pensiero, M. Marovich, C. Dieffenbach, W. Wagner, C.
Gittens, J. Yalley-Ogunro, M. Nowak, R. Siliciano, D. Persaud, S. Deeks,
N. Chomont, J. Ananworanich, L. Picker, F. Stephens, R. Hamel, K. Kelly
and L. Dunne for advice, assistance and reagents. The
SIVMAC239 peptides were obtained from the National Institutes
of Health (NIH) AIDS Research and Reference Reagent Program. We
acknowledge support from the US Army Medical Research and Material
Command and the US Military HIV Research Program through its cooperative
agreement with the Henry M. Jackson Foundation for the Advancement of
Military Medicine (W81XWH-07-2-0067, W81XWH-11-2-0174); the NIH
(AI060354, AI078526, AI084794, AI095985, AI096040, AI100645); and the
Ragon Institute of MGH, MIT and Harvard. The views expressed in this
manuscript are those of the authors and do not represent the official
views of the Department of the Army or the Department of Defense.
NR 28
TC 128
Z9 132
U1 6
U2 27
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0028-0836
EI 1476-4687
J9 NATURE
JI Nature
PD AUG 7
PY 2014
VL 512
IS 7512
BP 74
EP +
DI 10.1038/nature13594
PG 15
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA AM5NX
UT WOS:000339908000034
PM 25042999
ER
PT J
AU Bozue, J
Cote, CK
Chance, T
Kugelman, J
Kern, SJ
Kijek, TK
Jenkins, A
Mou, S
Moody, K
Fritz, D
Robinson, CG
Bell, T
Worsham, P
AF Bozue, Joel
Cote, Christopher K.
Chance, Taylor
Kugelman, Jeffrey
Kern, Steven J.
Kijek, Todd K.
Jenkins, Amy
Mou, Sherry
Moody, Krishna
Fritz, David
Robinson, Camenzind G.
Bell, Todd
Worsham, Patricia
TI A Yersinia pestis tat Mutant Is Attenuated in Bubonic and Small-Aerosol
Pneumonic Challenge Models of Infection but Not As Attenuated by
Intranasal Challenge
SO PLOS ONE
LA English
DT Article
ID ARGININE TRANSLOCATION SYSTEM; PROTEIN-TRANSPORT SYSTEM;
ESCHERICHIA-COLI; SIGNAL PEPTIDE; V-ANTIGEN; PLASMINOGEN-ACTIVATOR;
PSEUDOMONAS-SYRINGAE; REGULATORY PROTEIN; BIOFILM FORMATION; PLAGUE
VACCINE
AB Bacterial proteins destined for the Tat pathway are folded before crossing the inner membrane and are typically identified by an N-terminal signal peptide containing a twin arginine motif. Translocation by the Tat pathway is dependent on the products of genes which encode proteins possessing the binding site of the signal peptide and mediating the actual translocation event. In the fully virulent CO92 strain of Yersinia pestis, the tatA gene was deleted. The mutant was assayed for loss of virulence through various in vitro and in vivo assays. Deletion of the tatA gene resulted in several consequences for the mutant as compared to wild-type. Cell morphology of the mutant bacteria was altered and demonstrated a more elongated form. In addition, while cultures of the mutant strain were able to produce a biofilm, we observed a loss of adhesion of the mutant biofilm structure compared to the biofilm produced by the wild-type strain. Immuno-electron microscopy revealed a partial disruption of the F1 antigen on the surface of the mutant. The virulence of the Delta tatA mutant was assessed in various murine models of plague. The mutant was severely attenuated in the bubonic model with full virulence restored by complementation with the native gene. After small-particle aerosol challenge in a pneumonic model of infection, the mutant was also shown to be attenuated. In contrast, when mice were challenged intranasally with the mutant, very little difference in the LD50 was observed between wild-type and mutant strains. However, an increased time-to- death and delay in bacterial dissemination was observed in mice infected with the Delta tatA mutant as compared to the parent strain. Collectively, these findings demonstrate an essential role for the Tat pathway in the virulence of Y. pestis in bubonic and small-aerosol pneumonic infection but less important role for intranasal challenge.
C1 [Bozue, Joel; Cote, Christopher K.; Kijek, Todd K.; Jenkins, Amy; Mou, Sherry; Moody, Krishna; Fritz, David; Worsham, Patricia] US Army, Med Res Inst Infect Dis, Bacteriol Div, Ft Detrick, MD 21702 USA.
[Chance, Taylor; Robinson, Camenzind G.; Bell, Todd] US Army, Med Res Inst Infect Dis, Div Pathol, Ft Detrick, MD 21702 USA.
[Kugelman, Jeffrey] US Army, Med Res Inst Infect Dis, Ctr Genome Sci, Ft Detrick, MD 21702 USA.
[Kern, Steven J.] US Army, Med Res Inst Infect Dis, Off Res Support, Ft Detrick, MD 21702 USA.
RP Bozue, J (reprint author), US Army, Med Res Inst Infect Dis, Bacteriol Div, Ft Detrick, MD 21702 USA.
EM joel.a.bozue@us.army.mil
FU Defense Threat Reduction Agency JSTO-CBD [923698]
FX The research described herein was sponsored by the Defense Threat
Reduction Agency JSTO-CBD (project number 923698). The funders had no
role in study design, data collection and analysis, decision to publish,
or preparation of the manuscript.
NR 94
TC 0
Z9 0
U1 0
U2 7
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD AUG 7
PY 2014
VL 9
IS 8
AR e104524
DI 10.1371/journal.pone.0104524
PG 18
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA AM6SB
UT WOS:000339993900072
PM 25101850
ER
PT J
AU Rhon, DI
Boyles, RB
Cleland, JA
AF Rhon, Daniel I.
Boyles, Robert B.
Cleland, Joshua A.
TI One-Year Outcome of Subacromial Corticosteroid Injection Compared With
Manual Physical Therapy for the Management of the Unilateral Shoulder
Impingement Syndrome
SO ANNALS OF INTERNAL MEDICINE
LA English
DT Article
ID RANDOMIZED CONTROLLED-TRIAL; PAIN INTENSITY MEASUREMENT; ROTATOR CUFF
TENDINITIS; FEAR-AVOIDANCE BELIEFS; QUALITY-OF-LIFE; GENERAL-PRACTICE;
PRIMARY-CARE; CLINICAL-TRIAL; PATIENT CHARACTERISTICS; MANIPULATIVE
THERAPY
AB Background: Corticosteroid injections (CSIs) and physical therapy are used to treat patients with the shoulder impingement syndrome (SIS) but have never been directly compared.
Objective: To compare the effectiveness of 2 common nonsurgical treatments for SIS.
Design: Randomized, single-blind, comparative-effectiveness, parallel-group trial. (ClinicalTrials.gov: NCT01190891)
Setting: Military hospital-based outpatient clinic in the United States.
Patients: 104 patients aged 18 to 65 years with unilateral SIS between June 2010 and March 2012.
Intervention: Random assignment into 2 groups: 40-mg triamcinolone acetonide subacromial CSI versus 6 sessions of manual physical therapy.
Measurements: The primary outcome was change in Shoulder Pain and Disability Index scores at 1 year. Secondary outcomes included the Global Rating of Change scores, the Numeric Pain Rating Scale scores, and 1-year health care use.
Results: Both groups demonstrated approximately 50% improvement in Shoulder Pain and Disability Index scores maintained through 1 year; however, the mean difference between groups was not significant (1.5% [95% CI, -6.3% to 9.4%]). Both groups showed improvements in Global Rating of Change scale and pain rating scores, but between-group differences in scores for the Global Rating of Change scale (0 [CI, -2 to 1]) and pain rating (0.4 [CI, -0.5 to 1.2]) were not significant. During the 1-year follow-up, patients receiving CSI had more SIS-related visits to their primary care provider (60% vs. 37%) and required additional steroid injections (38% vs. 20%), and 19% needed physical therapy. Transient pain from the CSI was the only adverse event reported.
Limitation: The study occurred at 1 center with patients referred to physical therapy.
Conclusion: Both groups experienced significant improvement. The manual physical therapy group used less 1-year SIS-related health care resources than the CSI group.
C1 Madigan Army Med, Tacoma, WA USA.
Univ Puget Sound, Tacoma, WA 98416 USA.
Franklin Pierce Univ, Manchester, NH USA.
RP Rhon, DI (reprint author), Brooke Army Med Ctr, Ctr Intrepid, 3551 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA.
FU Cardon Rehabilitation Products through the American Academy of
Orthopaedic Manual Physical Therapists
FX Primary Funding Source: Cardon Rehabilitation Products through the
American Academy of Orthopaedic Manual Physical Therapists.
NR 74
TC 18
Z9 18
U1 4
U2 17
PU AMER COLL PHYSICIANS
PI PHILADELPHIA
PA INDEPENDENCE MALL WEST 6TH AND RACE ST, PHILADELPHIA, PA 19106-1572 USA
SN 0003-4819
EI 1539-3704
J9 ANN INTERN MED
JI Ann. Intern. Med.
PD AUG 5
PY 2014
VL 161
IS 3
BP 161
EP U108
DI 10.7326/M13-2199
PG 10
WC Medicine, General & Internal
SC General & Internal Medicine
GA AN3KH
UT WOS:000340486000001
PM 25089860
ER
PT J
AU West, AL
Griep, MH
Cole, DP
Karna, SP
AF West, Abby L.
Griep, Mark H.
Cole, Daniel P.
Karna, Shashi P.
TI DNase 1 Retains Endodeoxyribonuclease Activity Following Gold
Nanocluster Synthesis
SO ANALYTICAL CHEMISTRY
LA English
DT Article
ID REAL-TIME PCR; HIGHLY FLUORESCENT; DIRECTED SYNTHESIS; QUANTUM DOTS;
CONTAMINATION; SAMPLES; AGENTS; GLUTATHIONE; CLUSTERS
AB Here we present the synthesis of the enzyme DNase 1 stabilized gold nanoclusters (DNase 1:AuNCs) with core size consisting of either 8 or 25 atoms. The DNase 1:Au8NCs exhibit blue fluorescence whereas the DNase 1:Au25NCs are red emitting. In addition to the intense fluorescence emission, the synthesized DNase 1:AuNC hybrid retains the native functionality of the protein, allowing simultaneous detection and digestion of DNA with a detection limit of 2 mu g/mL. The DNase 1:AuNCs could be conveniently employed as efficient and fast sensors to augment the current time-consuming DNA contamination analysis techniques.
C1 [West, Abby L.; Griep, Mark H.; Karna, Shashi P.] US Army Res Lab, Weap & Mat Res Directorate, ATTN RDRL WM, Aberdeen, MD 21005 USA.
[Cole, Daniel P.] US Army Res Lab, Vehicle Technol Directorate, ATTN RDRL VT, Aberdeen, MD 21005 USA.
RP West, AL (reprint author), US Army Res Lab, Weap & Mat Res Directorate, ATTN RDRL WM, 4600 Deer Creek Loop, Aberdeen, MD 21005 USA.
EM abby.west2.ctr@mail.mil
FU Maryland NanoCenter; NispLab; U.S. Army Research Laboratory [NNL09AA00A]
FX The authors thank V. Rodriguez Santiago for the X-ray photoelectron
spectroscopy. For transmission electron microscopy (TEM) analysis, we
acknowledge the support of the Maryland NanoCenter and its NispLab. The
NispLab is supported in part by the NSF as a MRSEC Shared Experimental
Facility. The authors also thank M. Sellers and J. Martin for aid and
input on this work. A. West acknowledges the receipt of an ARL-ORAU
Postdoctoral Associateship. D.P.C. is a contractor to the U.S. Army
Research Laboratory under contract NNL09AA00A.
NR 27
TC 12
Z9 12
U1 5
U2 72
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0003-2700
EI 1520-6882
J9 ANAL CHEM
JI Anal. Chem.
PD AUG 5
PY 2014
VL 86
IS 15
BP 7377
EP 7382
DI 10.1021/ac5005794
PG 6
WC Chemistry, Analytical
SC Chemistry
GA AM7XD
UT WOS:000340081100035
PM 24999001
ER
PT J
AU Pamplin, JC
Cancio, LC
AF Pamplin, Jeremy C.
Cancio, Leopoldo C.
TI The Power of Suggestion
SO RESPIRATORY CARE
LA English
DT Editorial Material
C1 [Pamplin, Jeremy C.; Cancio, Leopoldo C.] US Army Inst Surg Res, Joint Base San Antonio, Ft Sam Houston, TX 78234 USA.
RP Pamplin, JC (reprint author), US Army Inst Surg Res, Joint Base San Antonio, Ft Sam Houston, TX 78234 USA.
NR 4
TC 0
Z9 0
U1 0
U2 0
PU DAEDALUS ENTERPRISES INC
PI IRVING
PA 9425 N MAC ARTHUR BLVD, STE 100, IRVING, TX 75063-4706 USA
SN 0020-1324
EI 1943-3654
J9 RESP CARE
JI Respir. Care
PD AUG
PY 2014
VL 59
IS 8
BP 1310
EP 1311
DI 10.4187/respcare.03498
PG 2
WC Critical Care Medicine; Respiratory System
SC General & Internal Medicine; Respiratory System
GA CA8VV
UT WOS:000349199900020
PM 25233519
ER
PT J
AU Zaghloul, AI
Bird, TS
Bernhard, JT
AF Zaghloul, Amir I.
Bird, Trevor S.
Bernhard, Jennifer T.
TI Guest Editorial Special Issue on Antenna Design and Integration in Smart
Sensors
SO IEEE SENSORS JOURNAL
LA English
DT Editorial Material
C1 [Zaghloul, Amir I.] US Army Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA.
[Zaghloul, Amir I.] Virginia Tech, Dept Elect & Comp Engn, Blacksburg, VA 24061 USA.
[Bird, Trevor S.] Macquarie Univ, Dept Engn, Sydney, NSW 2109, Australia.
[Bernhard, Jennifer T.] Univ Illinois, Dept Elect & Comp Engn, Urbana, IL 61801 USA.
RP Zaghloul, AI (reprint author), US Army Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA.
EM amir.i.zaghloul.civ@mail.mil; ts.bird@ieee.org; jbernhar@illinois.edu
OI Bernhard, Jennifer/0000-0002-0929-387X
NR 0
TC 0
Z9 0
U1 0
U2 3
PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
PI PISCATAWAY
PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA
SN 1530-437X
EI 1558-1748
J9 IEEE SENS J
JI IEEE Sens. J.
PD AUG
PY 2014
VL 14
IS 8
BP 2405
EP 2405
DI 10.1109/JSEN.2014.2333571
PG 1
WC Engineering, Electrical & Electronic; Instruments & Instrumentation;
Physics, Applied
SC Engineering; Instruments & Instrumentation; Physics
GA AY0XL
UT WOS:000347317600001
ER
PT J
AU Lesho, EP
Waterman, PE
Chukwuma, U
McAuliffe, K
Neumann, C
Julius, MD
Crouch, H
Chandrasekera, R
English, JF
Clifford, RJ
Kester, KE
AF Lesho, Emil P.
Waterman, Paige E.
Chukwuma, Uzo
McAuliffe, Kathryn
Neumann, Charlotte
Julius, Michael D.
Crouch, Helen
Chandrasekera, Ruvani
English, Judith F.
Clifford, Robert J.
Kester, Kent E.
TI The Antimicrobial Resistance Monitoring and Research (ARMoR) Program:
The US Department of Defense Response to Escalating Antimicrobial
Resistance
SO CLINICAL INFECTIOUS DISEASES
LA English
DT Editorial Material
DE antimicrobial resistance; surveillance; infection prevention; Department
of Defense
ID METALLO-BETA-LACTAMASE; STAPHYLOCOCCUS-AUREUS; PROVIDENCIA-STUARTII;
ACINETOBACTER-BAUMANNII; SURVEILLANCE NETWORK; CLINICAL ISOLATE;
UNITED-STATES; BLA(NDM-1); SEQUENCE; EPIDEMIOLOGY
AB Responding to escalating antimicrobial resistance (AMR), the US Department of Defense implemented an enterprise-wide collaboration, the Antimicrobial Resistance Monitoring and Research Program, to aid in infection prevention and control. It consists of a network of epidemiologists, bioinformaticists, microbiology researchers, policy makers, hospital-based infection preventionists, and healthcare providers who collaborate to collect relevant AMR data, conduct centralized molecular characterization, and use AMR characterization feedback to implement appropriate infection prevention and control measures and influence policy. A particularly concerning type of AMR, carbapenem-resistant Enterobacteriaceae, significantly declined after the program was launched. Similarly, there have been no further reports or outbreaks of another concerning type of AMR, colistin resistance in Acinetobacter, in the Department of Defense since the program was initiated. However, bacteria containing AMR-encoding genes are increasing. To update program stakeholders and other healthcare systems facing such challenges, we describe the processes and impact of the program.
C1 [Lesho, Emil P.; Waterman, Paige E.; Julius, Michael D.; Clifford, Robert J.] Walter Reed Army Inst Res, Multidrug Resistant Organism Repository & Surveil, Silver Spring, MD USA.
[Waterman, Paige E.; Chandrasekera, Ruvani] Global Emerging Infect Surveillance & Response Sy, Armed Forces Hlth Surveillance Ctr, Silver Spring, MD USA.
[Lesho, Emil P.; Waterman, Paige E.; Kester, Kent E.] Uniformed Serv Univ Hlth Sci, F Edward Hebert Sch Med, Bethesda, MD 20814 USA.
[Chukwuma, Uzo; McAuliffe, Kathryn; Neumann, Charlotte] Navy & Marine Corps Publ Hlth, EpiData Ctr Dept, Portsmouth, VA USA.
[Crouch, Helen] Brooke Army Med Ctr, San Antonio, TX USA.
[English, Judith F.] Navy Bur Med & Surg, Falls Church, VA USA.
RP Lesho, EP (reprint author), 503 Robert Grant Ave, Silver Spring, MD 20910 USA.
EM p.lesho.mil@mail.mil
OI Chandrasekera, Ruvani/0000-0002-6251-2154
NR 33
TC 14
Z9 14
U1 1
U2 6
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 1058-4838
EI 1537-6591
J9 CLIN INFECT DIS
JI Clin. Infect. Dis.
PD AUG 1
PY 2014
VL 59
IS 3
BP 390
EP 397
DI 10.1093/cid/ciu319
PG 8
WC Immunology; Infectious Diseases; Microbiology
SC Immunology; Infectious Diseases; Microbiology
GA AQ6KG
UT WOS:000342919700011
PM 24795331
ER
PT J
AU Webster, MA
Rigor, IG
Nghiem, SV
Kurtz, NT
Farrell, SL
Perovich, DK
Sturm, M
AF Webster, Melinda A.
Rigor, Ignatius G.
Nghiem, Son V.
Kurtz, Nathan T.
Farrell, Sinead L.
Perovich, Donald K.
Sturm, Matthew
TI Interdecadal changes in snow depth on Arctic sea ice
SO JOURNAL OF GEOPHYSICAL RESEARCH-OCEANS
LA English
DT Article
ID THERMAL-CONDUCTIVITY; THICKNESS; PRODUCTS
AB Snow plays a key role in the growth and decay of Arctic sea ice. In winter, it insulates sea ice from cold air temperatures, slowing sea ice growth. From spring to summer, the albedo of snow determines how much insolation is absorbed by the sea ice and underlying ocean, impacting ice melt processes. Knowledge of the contemporary snow depth distribution is essential for estimating sea ice thickness and volume, and for understanding and modeling sea ice thermodynamics in the changing Arctic. This study assesses spring snow depth distribution on Arctic sea ice using airborne radar observations from Operation IceBridge for 2009-2013. Data were validated using coordinated in situ measurements taken in March 2012 during the Bromine, Ozone, and Mercury Experiment (BROMEX) field campaign. We find a correlation of 0.59 and root-mean-square error of 5.8 cm between the airborne and in situ data. Using this relationship and Ice-Bridge snow thickness products, we compared the recent results with data from the 1937, 1954-1991 Soviet drifting ice stations. The comparison shows thinning of the snowpack, from 35.1 +/- 9.4 to 22.2 +/- 1.9 cm in the western Arctic, and from 32.8 +/- 9.4 to 14.5 +/- 1.9 cm in the Beaufort and Chukchi seas. These changes suggest a snow depth decline of 37 +/- 29% in the western Arctic and 56 +/- 33% in the Beaufort and Chukchi seas. Thinning is negatively correlated with the delayed onset of sea ice freezeup during autumn.
C1 [Webster, Melinda A.; Rigor, Ignatius G.] Univ Washington, Appl Phys Lab, Polar Sci Ctr, Seattle, WA 98105 USA.
[Nghiem, Son V.] CALTECH, Jet Prop Lab, Pasadena, CA USA.
[Kurtz, Nathan T.; Farrell, Sinead L.] NASA, Goddard Space Flight Ctr, Hydrospher & Biospher Sci Lab, Greenbelt, MD 20771 USA.
[Farrell, Sinead L.] Univ Maryland, Earth Syst Sci Interdisciplinary Ctr, College Pk, MD 20742 USA.
[Perovich, Donald K.] US Army Corps Engineers, Engn Res & Dev Ctr, Cold Reg Res & Engn Lab, Hanover, NH USA.
[Sturm, Matthew] Univ Alaska Fairbanks, Inst Geophys, Fairbanks, AK 99775 USA.
RP Webster, MA (reprint author), Univ Washington, Appl Phys Lab, Polar Sci Ctr, Seattle, WA 98105 USA.
EM melindaw@uw.edu
RI Farrell, Sinead/F-5586-2010
OI Farrell, Sinead/0000-0003-3222-2751
FU NASA Cryospheric Sciences Program
FX Snow data from the 2012 BROMEX field campaign are available upon
request. Meteorological data are available at
http://www.esrl.noaa.gov/gmd/dv/. The IceBridge quick-look and standard
snow depth products are available at https://nsidc.org/data/docs
/daac/icebridge/evaluation_products/sea-ice-freeboard-snowdepththickness
-quicklook-index.html and http://nsidc. org/data/idcsi2.html. The Soviet
station snow data are available at http://dx.doi.org/10.7265/N5MS3QNJ.
Ice Mass Balance buoy data are available at
http://IMB.crrel.usace.army.mil. The sea ice freezeup product from
passive microwave satellite data is available at
http://neptune.gsfc.nasa.gov/csb/index.php? section=54. This research
was supported by the National Aeronautics and Space Administration
(NASA), and by contributors to the U.S. Interagency Arctic Buoy Program,
which include the U.S. Coast Guard, NAVO, NIC, NOAA, NSF, and ONR. This
is JISAO contribution 2225. The research carried out at the Jet
Propulsion Laboratory, California Institute of Technology, was supported
by the NASA Cryospheric Sciences Program. We thank Jacqueline A.
Richter-Menge of the U.S. Army Cold Regions Research and Engineering
Laboratory for the planning and coordination of the IceBridge flight
operation with the BROMEX field campaign, and Stephen Warren for helpful
discussions. We thank UMIAQ, the Barrow whaling community, and the
Barrow Arctic Science Consortium for their assistance in the BROMEX
field campaign.
NR 42
TC 27
Z9 28
U1 4
U2 29
PU AMER GEOPHYSICAL UNION
PI WASHINGTON
PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA
SN 2169-9275
EI 2169-9291
J9 J GEOPHYS RES-OCEANS
JI J. Geophys. Res.-Oceans
PD AUG
PY 2014
VL 119
IS 8
BP 5395
EP 5406
DI 10.1002/2014JC009985
PG 12
WC Oceanography
SC Oceanography
GA AQ1CR
UT WOS:000342519500039
ER
PT J
AU Hoge, CW
Warner, CH
Castro, CA
AF Hoge, Charles W.
Warner, Christopher H.
Castro, Carl A.
TI Mental Health and the Army
SO JAMA PSYCHIATRY
LA English
DT Letter
ID ASSESS RISK; RESILIENCE; SOLDIERS; STARRS; PREVALENCE; BEHAVIOR; SUICIDE
C1 [Hoge, Charles W.] Walter Reed Army Inst Res, Ctr Psychiat & Neurosci, Silver Spring, MD 20910 USA.
[Warner, Christopher H.] 101st Airborne Div, Ft Campbell, KY USA.
[Castro, Carl A.] Univ So Calif, Sch Social Work, Los Angeles, CA 90089 USA.
RP Hoge, CW (reprint author), Walter Reed Army Inst Res, Ctr Psychiat & Neurosci, Silver Spring, MD 20910 USA.
EM charles.hoge@us.army.mil
NR 9
TC 5
Z9 5
U1 2
U2 4
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA
SN 2168-622X
EI 2168-6238
J9 JAMA PSYCHIAT
JI JAMA Psychiatry
PD AUG
PY 2014
VL 71
IS 8
BP 965
EP 966
PG 2
WC Psychiatry
SC Psychiatry
GA AP0SP
UT WOS:000341774600016
PM 25102900
ER
PT J
AU Hackman, RM
Aggarwal, BB
Applebaum, RS
White, RWD
Dubick, MA
Heber, D
Ito, T
Johnson, GH
Keen, CL
Winters, BL
Stohs, SJ
AF Hackman, Robert M.
Aggarwal, Bharat B.
Applebaum, Rhona S.
White, Ralph W. deVere
Dubick, Michael A.
Heber, David
Ito, Toshinori
Johnson, Guy H.
Keen, Carl L.
Winters, Barbara L.
Stohs, Sidney J.
TI Forecasting Nutrition Research in 2020
SO JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION
LA English
DT Editorial Material
DE clinical nutrition; obesity; microbiome; gene expression; nutrition
education; public health
ID PROCESSED FOODS; OBESITY; HEALTH; CANCER; ADULTS
C1 [Hackman, Robert M.; Keen, Carl L.] Univ Calif Davis, Dept Nutr, Davis, CA 95616 USA.
[Keen, Carl L.] Univ Calif Davis, Dept Internal Med, Davis, CA 95616 USA.
[Aggarwal, Bharat B.] Univ Texas MD Anderson Canc Ctr, Dept Expt Therapeut, Houston, TX 77030 USA.
[Applebaum, Rhona S.] Coca Cola Co, Atlanta, GA USA.
[White, Ralph W. deVere] Dept Urol, Sacramento, CA USA.
[White, Ralph W. deVere] UC Davis Comprehens Canc Ctr, Sacramento, CA USA.
[Dubick, Michael A.] US Army, Inst Surg Res, San Antonio, TX USA.
[Heber, David] Univ Calif Los Angeles, Dept Med, Los Angeles, CA 90024 USA.
[Heber, David] Univ Calif Los Angeles, Dept Publ Hlth, Los Angeles, CA USA.
[Ito, Toshinori] Osaka Univ, Grad Sch Med, Dept Complementary & Alternat Med, Osaka, Japan.
[Johnson, Guy H.] Nutr Solut Inc, Minneapolis, MN USA.
[Winters, Barbara L.] Campbell Soup Co, Camden, NJ USA.
[Stohs, Sidney J.] Creighton Univ, Sch Pharm & Hlth Profess, Omaha, NE 68178 USA.
RP Hackman, RM (reprint author), Univ Calif Davis, Dept Nutr, 1 Shields Ave,3135 Meyer Hall, Davis, CA 95616 USA.
EM rmhackman@ucdavis.edu
RI Aggarwal, Bharat/G-3388-2013
NR 32
TC 1
Z9 1
U1 0
U2 13
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND
SN 0731-5724
EI 1541-1087
J9 J AM COLL NUTR
JI J. Am. Coll. Nutr.
PD AUG
PY 2014
VL 33
IS 4
BP 340
EP 346
DI 10.1080/07315724.2014.943113
PG 7
WC Nutrition & Dietetics
SC Nutrition & Dietetics
GA AP5SV
UT WOS:000342139900010
PM 25144361
ER
PT J
AU Blackburn, JK
Skrypnyk, A
Bagamian, KH
Nikolich, MP
Bezymennyi, M
Skrypnyk, V
AF Blackburn, Jason K.
Skrypnyk, Artem
Bagamian, Karoun H.
Nikolich, Mikeljon P.
Bezymennyi, Maksym
Skrypnyk, Valeriy
TI Anthrax in a Backyard Domestic Dog in Ukraine: A Case Report
SO VECTOR-BORNE AND ZOONOTIC DISEASES
LA English
DT Article
DE Dogs; Anthrax; Bacillus anthracis; Ukraine; Surveillance
ID NATIONAL-PARK
AB Anthrax has been reported in domestic and wild dogs throughout much of the world. Generally, canids are considered resistant to anthrax, although there are several reports of anthrax deaths in both wild and domestic canid populations. Prior to 2012, anthrax had not been reported in dogs in Ukraine, despite a long history in livestock and wildlife. An outbreak involving at least one cow and one dog was reported from a backyard setting in southern Ukraine in August of 2012. Laboratory results and epizootic data were compiled from official investigation reports of regional and state veterinary services involved in the case response. A single dog died after being fed meat and bones from an illegally slaughtered heifer that died of anthrax 5 days earlier. On the evening of the dog's death, the dog refused food or water; however, there were no other clinical signs. Laboratory tests of dog tissue included traditional bacteriology for Bacillus anthracis, a small rodent bioassay for virulence, and immunoprecipitation tests (IPT). IPT was positive, viable B. anthracis colonies were cultured, and a bioassay confirmed virulence. This was the first confirmed case of canid anthrax in Ukraine. This case report serves to remind veterinary officials that anthrax can affect a wide number of species. We advise surveillance systems remain flexible and include animals that might not otherwise be tested.
C1 [Blackburn, Jason K.; Bagamian, Karoun H.] Univ Florida, Dept Geog, Spatial Epidemiol & Ecol Res Lab, Gainesville, FL 32611 USA.
[Blackburn, Jason K.; Bagamian, Karoun H.] Univ Florida, Emerging Pathogens Inst, Gainesville, FL 32611 USA.
[Skrypnyk, Artem] Black & Veatch Special Projects Corp, Kiev, Ukraine.
[Nikolich, Mikeljon P.] Walter Reed Army Inst Res, Silver Spring, MD USA.
[Bezymennyi, Maksym; Skrypnyk, Valeriy] State Sci Control Inst Biotechnol & Strains Micro, Kiev, Ukraine.
RP Blackburn, JK (reprint author), Univ Florida, Dept Geog, Spatial Epidemiol & Ecol Res Lab, 3141 Turlington Hall, Gainesville, FL 32611 USA.
EM jkblackburn@ufl.edu
FU US Defense Threat Reduction Agency's (DTRA) Cooperative Biological
Engagement Program in Ukraine under the UP-2 Project
FX This case study was funded by the US Defense Threat Reduction Agency's
(DTRA) Cooperative Biological Engagement Program in Ukraine under the
UP-2 Project. G. Glass provided insights and comments that greatly
strengthened this manuscript.
NR 10
TC 2
Z9 2
U1 1
U2 6
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1530-3667
EI 1557-7759
J9 VECTOR-BORNE ZOONOT
JI Vector-Borne Zoonotic Dis.
PD AUG
PY 2014
VL 14
IS 8
BP 615
EP 617
DI 10.1089/vbz.2013.1519
PG 3
WC Public, Environmental & Occupational Health; Infectious Diseases
SC Public, Environmental & Occupational Health; Infectious Diseases
GA AP5VM
UT WOS:000342146800012
PM 25072993
ER
PT J
AU De Lorenzo, RA
Ward, JA
Jordan, BS
Hanson, CE
AF De Lorenzo, Robert A.
Ward, John A.
Jordan, Bryan S.
Hanson, Chris E.
TI Relationships of Intraosseous and Systemic Pressure Waveforms in a Swine
Model
SO ACADEMIC EMERGENCY MEDICINE
LA English
DT Article
ID BONE-MARROW; BLOOD-PRESSURE; INFUSION
AB Background Despite some focus on the use of intraosseous (IO) catheters to obtain laboratory samples, very little is known about the potential for obtaining other forms of clinical data. Largely unstudied is the relationship between IO pressures (IOPs) and systemic hemodynamic pressures such as mean arterial pressure (MAP) and central venous pressures (CVP). Objectives The objective was to explore the relationship between hemodynamic parameters (blood pressures) measured through an IO catheter and intravascular catheters placed in the arterial and central venous circulation. Methods Eight pigs (Sus scrofa) weighing 30 to 45kg were sedated with a short-acting agent, intubated with a cuffed endotracheal tube, and anesthetized with 2% to 3% isoflurane. Intravascular catheters were placed into the femoral or carotid artery and the femoral or jugular vein for MAP and CVP measurements. IO catheters, 15mm for the sternum and 25mm for the long bones, were placed percutaneously into the proximal tibia, proximal femur, proximal humerus, right proximal ulna, and/or sternum. Pressures were recorded during normotension, hypotension, and hypertension. Results Averaged across all eight animals, the means (ranges) for baseline systemic pressures were as follows: MAP=66.5 (55.6 to 76.7) mmHg, tibia IOP=17.4 (9.3 to 34.5) mmHg, femur IOP =18.4 (3.3 to 33.1) mmHg, humerus IOP=15.7 (2.8 to 28.9) mmHg, ulna IOP=16.0 (7.9 to 25.6) mmHg, sternum IOP=5.7 (-0.5 to 47.9) mmHg, and CVP=2.7mmHg (-3.3 to 7.9) mmHg. The best median correlation occurred between femur IOP and mean MAP (r=0.65). The four highest correlations between IOP and MAP were associated with mean femur IOP. Only one IO site had a correlation coefficient over 0.50 for CVP. The long bones tended to correlate better with the MAP and the sternum tended to correlate better with the CVP. Nonlinearity was observed in the actively rising pressure phases, which can be explained by a hysteresis model. Conclusions The relationship between IOP and MAP or CVP is variable by site, with the MAP and CVP tending to be estimated by the femur and sternum, respectively. The relationship to actively rising pressures is nonlinear and a hysteresis model is proposed to explain the phase change. Further experimentation is needed to refine the IOP relationship to the MAP and CVP and assess the potential of these measurements to provide clinically relevant information.
C1 [De Lorenzo, Robert A.; Jordan, Bryan S.] US Army Inst Surg Res, Tact Combat Casualty Care Res Program, Ft Sam Houston, TX 78234 USA.
[Ward, John A.] Brooke Army Med Ctr, Dept Clin Invest, Ft Sam Houston, TX 78234 USA.
[Hanson, Chris E.] Dept Def Vet Serv Act, Ft Sam Houston, TX USA.
RP De Lorenzo, RA (reprint author), US Army Inst Surg Res, Tact Combat Casualty Care Res Program, Ft Sam Houston, TX 78234 USA.
EM robert.a.delorenzo.mil@mail.mil
FU Telemedicine and Technology Research Center, Ft. Detrick, MD
FX Funding was provided by a grant from the Telemedicine and Technology
Research Center, Ft. Detrick, MD.
NR 15
TC 0
Z9 0
U1 0
U2 4
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1069-6563
EI 1553-2712
J9 ACAD EMERG MED
JI Acad. Emerg. Med.
PD AUG
PY 2014
VL 21
IS 8
BP 899
EP 904
DI 10.1111/acem.12432
PG 6
WC Emergency Medicine
SC Emergency Medicine
GA AO8YC
UT WOS:000341640800010
PM 25154326
ER
PT J
AU Bandera, BC
Burgess, P
Strode, M
Sparks, P
Amin, A
AF Bandera, Bradley C.
Burgess, Pamela
Strode, Matthew
Sparks, Preston
Amin, Asna
TI Fatal Ischemic Proctitis in a Patient with a History of an Aortobi-iliac
Interposition Graft
SO AMERICAN SURGEON
LA English
DT Article
C1 [Bandera, Bradley C.; Burgess, Pamela; Strode, Matthew; Sparks, Preston; Amin, Asna] Dwight D Eisenhower Army Med Ctr, Dept Gen Surg, Ft Gordon, GA USA.
RP Bandera, BC (reprint author), Dwight D Eisenhower Army Med Ctr, 300 Hosp Rd, Ft Gordon, GA 30905 USA.
EM b.bandera07@comcast.net
NR 2
TC 0
Z9 0
U1 0
U2 0
PU SOUTHEASTERN SURGICAL CONGRESS
PI CUMMING
PA 115 SAMARITAN DR, #200, CUMMING, GA 30040-2354 USA
SN 0003-1348
EI 1555-9823
J9 AM SURGEON
JI Am. Surg.
PD AUG
PY 2014
VL 80
IS 8
BP E234
EP E235
PG 2
WC Surgery
SC Surgery
GA AP1FL
UT WOS:000341812500008
PM 25105378
ER
PT J
AU Burgess, P
Bandera, B
Rozelle, C
AF Burgess, Pamela
Bandera, Bradley
Rozelle, Christopher
TI Multifocal Glomangioma of the Gallbladder
SO AMERICAN SURGEON
LA English
DT Article
ID GLOMUS TUMORS
C1 [Burgess, Pamela; Bandera, Bradley; Rozelle, Christopher] Dwight D Eisenhower Army Med Ctr, Ft Gordon, GA 30905 USA.
RP Burgess, P (reprint author), Dwight D Eisenhower Army Med Ctr, 300 E Hosp Rd, Ft Gordon, GA 30905 USA.
EM pamela.l.burgess5.mil@mail.mil
NR 4
TC 0
Z9 0
U1 0
U2 0
PU SOUTHEASTERN SURGICAL CONGRESS
PI CUMMING
PA 115 SAMARITAN DR, #200, CUMMING, GA 30040-2354 USA
SN 0003-1348
EI 1555-9823
J9 AM SURGEON
JI Am. Surg.
PD AUG
PY 2014
VL 80
IS 8
BP E218
EP E220
PG 3
WC Surgery
SC Surgery
GA AP1FL
UT WOS:000341812500002
PM 25105372
ER
PT J
AU Venditto, VJ
Wieczorek, L
Molnar, S
Teque, F
Landucci, G
Watson, DS
Forthal, D
Polonis, VR
Levy, JA
Szoka, FC
AF Venditto, Vincent J.
Wieczorek, Lindsay
Molnar, Sebastian
Teque, Fernando
Landucci, Gary
Watson, Douglas S.
Forthal, Donald
Polonis, Victoria R.
Levy, Jay A.
Szoka, Francis C., Jr.
TI Chemically Modified Peptides Based on the Membrane-Proximal External
Region of the HIV-1 Envelope Induce High-Titer, Epitope-Specific
Nonneutralizing Antibodies in Rabbits
SO CLINICAL AND VACCINE IMMUNOLOGY
LA English
DT Article
ID IMMUNODEFICIENCY-VIRUS TYPE-1; BROADLY NEUTRALIZING ANTIBODIES; HUMAN
MONOCLONAL-ANTIBODIES; STRUCTURAL BASIS; 2F5-LIKE ANTIBODIES; IMMUNOGEN
DESIGN; GP41; VACCINE; CELL; 2F5
AB Broadly neutralizing monoclonal antibodies (bNAbs) 2F5 and 4E10 bind to the membrane proximal external region (MPER) of gp41 and also cross-react with phospholipids. In this study, we investigated if chemical modifications on the MPER adjacent to 2F5 and 4E10 epitopes using mimetics of inflammation-associated posttranslational modifications to induce 2F5- and 4E10-like bNAbs can break tolerance. We synthesized a series of chemically modified peptides spanning the MPER. The serine, threonine, and tyrosine residues in the peptides were modified with sulfate, phosphate, or nitrate moieties and presented in liposomes for rabbit immunizations. All immunizations resulted in high antisera titers directed toward both the modified and unmodified immunogens. Tyrosine modification was observed to significantly suppress antiepitope responses. Sera with strong anti-gp140 titers were purified by affinity chromatography toward the MPER peptide and found to possess a higher affinity toward the MPER than did the bNAbs 2F5 and 4E10. Modest neutralization was observed in the H9 neutralization assay, but neutralization was not observed in the TZM-bl cell or peripheral blood mononuclear cell (PBMC) neutralization assay platforms. Although neutralizing antibodies were not induced by this approach, we conclude that chemical modifications can increase the immune responses to poorly immunogenic antigens, suggesting that chemical modification in an appropriate immunization protocol should be explored further as an HIV-1 vaccine strategy.
C1 [Venditto, Vincent J.; Watson, Douglas S.; Szoka, Francis C., Jr.] Univ Calif San Francisco, Sch Pharm, Dept Bioengn, San Francisco, CA 94143 USA.
[Venditto, Vincent J.; Watson, Douglas S.; Szoka, Francis C., Jr.] Univ Calif San Francisco, Sch Pharm, Dept Therapeut Sci, San Francisco, CA 94143 USA.
[Wieczorek, Lindsay; Molnar, Sebastian; Polonis, Victoria R.] Walter Reed Army Inst Res, Lab Vaccine Immunol, Mil HIV Res Program, Silver Spring, MD USA.
[Wieczorek, Lindsay; Molnar, Sebastian] Henry M Jackson Fdn, Bethesda, MD USA.
[Teque, Fernando; Levy, Jay A.] Univ Calif San Francisco, Dept Med, San Francisco, CA 94143 USA.
[Landucci, Gary; Forthal, Donald] Univ Calif Irvine, Dept Med, Div Infect Dis, Irvine, CA 92717 USA.
RP Szoka, FC (reprint author), Univ Calif San Francisco, Sch Pharm, Dept Bioengn, San Francisco, CA 94143 USA.
EM szoka@cgl.ucsf.edu
FU NIH [R01 GM061851, R21 AI093135, HHSN27201100016C]; U.S. Army Medical
Research and Material Command [DAMD17-93-V-3004]; Henry M. Jackson
Foundation; Division of AIDS, NIAID, NIH; NIAID, NIH [F32AI095062]
FX This work was supported by NIH grants R01 GM061851, R21 AI093135, and
HHSN27201100016C and by cooperative agreement DAMD17-93-V-3004 between
the U.S. Army Medical Research and Material Command, the Henry M.
Jackson Foundation, and the Division of AIDS, NIAID, NIH. V. J. Venditto
was supported by Ruth L. Kirschstein National Research Service Award
F32AI095062 from the NIAID, NIH.
NR 44
TC 5
Z9 5
U1 2
U2 10
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 1556-6811
EI 1556-679X
J9 CLIN VACCINE IMMUNOL
JI Clin. Vaccine Immunol.
PD AUG
PY 2014
VL 21
IS 8
BP 1086
EP 1093
DI 10.1128/CVI.00320-14
PG 8
WC Immunology; Infectious Diseases; Microbiology
SC Immunology; Infectious Diseases; Microbiology
GA AO8SH
UT WOS:000341624000008
PM 24872518
ER
PT J
AU Mudhasani, R
Kota, KP
Retterer, C
Tran, JP
Whitehouse, CA
Bavari, S
AF Mudhasani, Rajini
Kota, Krishna P.
Retterer, Cary
Tran, Julie P.
Whitehouse, Chris A.
Bavari, Sina
TI High Content Image-Based Screening of a Protease Inhibitor Library
Reveals Compounds Broadly Active against Rift Valley Fever Virus and
Other Highly Pathogenic RNA Viruses
SO PLOS NEGLECTED TROPICAL DISEASES
LA English
DT Article
ID CYTOPLASMIC TAILS; DENGUE VIRUS; GLYCOPROTEINS; PCR; MICROTUBULES;
EXPRESSION; INFECTION; EPIDEMIC; DISEASE; MITOSIS
AB High content image-based screening was developed as an approach to test a protease inhibitor small molecule library for antiviral activity against Rift Valley fever virus (RVFV) and to determine their mechanism of action. RVFV is the causative agent of severe disease of humans and animals throughout Africa and the Arabian Peninsula. Of the 849 compounds screened, 34 compounds exhibited >= 50% inhibition against RVFV. All of the hit compounds could be classified into 4 distinct groups based on their unique chemical backbone. Some of the compounds also showed broad antiviral activity against several highly pathogenic RNA viruses including Ebola, Marburg, Venezuela equine encephalitis, and Lassa viruses. Four hit compounds (C795-0925, D011-2120, F694-1532 and G202-0362), which were most active against RVFV and showed broad-spectrum antiviral activity, were selected for further evaluation for their cytotoxicity, dose response profile, and mode of action using classical virological methods and high-content imaging analysis. Time-of-addition assays in RVFV infections suggested that D011-2120 and G202-0362 targeted virus egress, while C795-0925 and F694-1532 inhibited virus replication. We showed that D011-2120 exhibited its antiviral effects by blocking microtubule polymerization, thereby disrupting the Golgi complex and inhibiting viral trafficking to the plasma membrane during virus egress. While G202-0362 also affected virus egress, it appears to do so by a different mechanism, namely by blocking virus budding from the trans Golgi. F694-1532 inhibited viral replication, but also appeared to inhibit overall cellular gene expression. However, G202-0362 and C795-0925 did not alter any of the morphological features that we examined and thus may prove to be good candidates for antiviral drug development. Overall this work demonstrates that high-content image analysis can be used to screen chemical libraries for new antivirals and to determine their mechanism of action and any possible deleterious effects on host cellular biology.
C1 [Mudhasani, Rajini; Kota, Krishna P.; Retterer, Cary; Tran, Julie P.; Whitehouse, Chris A.; Bavari, Sina] US Army Med Res Inst Infect Dis, Mol & Translat Sci Div, Frederick, MD 21702 USA.
RP Mudhasani, R (reprint author), US Army Med Res Inst Infect Dis, Mol & Translat Sci Div, Frederick, MD 21702 USA.
EM sina.bavari.civ@mail.mil
FU Defense Threat Reduction Agency (DTRA), Joint Science and Technology
Office for Chem Bio Defense [JSTO-CBM.THRV.01.10.RD.19]
FX This study was supported by funding from the Defense Threat Reduction
Agency (DTRA), Joint Science and Technology Office for Chem Bio Defense
(JSTO-CBM.THRV.01.10.RD.19) to SB. The funders had no role in study
design, data collection and analysis, decision to publish, or
preparation of the manuscript.
NR 37
TC 11
Z9 12
U1 1
U2 17
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1935-2735
J9 PLOS NEGLECT TROP D
JI Plos Neglect. Trop. Dis.
PD AUG
PY 2014
VL 8
IS 8
AR e3095
DI 10.1371/journal.pntd.0003095
PG 16
WC Infectious Diseases; Parasitology; Tropical Medicine
SC Infectious Diseases; Parasitology; Tropical Medicine
GA AO8AN
UT WOS:000341574700056
PM 25144302
ER
PT J
AU Myint, KSA
Kipar, A
Jarman, RG
Gibbons, RV
Perng, GC
Flanagan, B
Mongkolsirichaikul, D
Van Gessel, Y
Solomon, T
AF Myint, Khin Saw Aye
Kipar, Anja
Jarman, Richard G.
Gibbons, Robert V.
Perng, Guey Chuen
Flanagan, Brian
Mongkolsirichaikul, Duangrat
Van Gessel, Yvonne
Solomon, Tom
TI Neuropathogenesis of Japanese Encephalitis in a Primate Model
SO PLOS NEGLECTED TROPICAL DISEASES
LA English
DT Article
ID CENTRAL-NERVOUS-SYSTEM; VIRUS INFECTION; NEURONAL DEATH; MICROGLIAL
ACTIVATION; NITRIC-OXIDE; IN-VITRO; T-CELLS; APOPTOSIS; ANTIGEN;
MACROPHAGES
AB Background: Japanese encephalitis (JE) is a major cause of mortality and morbidity for which there is no treatment. In addition to direct viral cytopathology, the inflammatory response is postulated to contribute to the pathogenesis. Our goal was to determine the contribution of bystander effects and inflammatory mediators to neuronal cell death.
Methodology/Principal Findings: Material from a macaque model was used to characterize the inflammatory response and cytopathic effects of JE virus (JEV). Intranasal JEV infection induced a non-suppurative encephalitis, dominated by perivascular, infiltrates of mostly T cells, alongside endothelial cell activation, vascular damage and blood brain barrier (BBB) leakage; in the adjacent parenchyma there was macrophage infiltration, astrocyte and microglia activation. JEV antigen was mostly in neurons, but there was no correlation between intensity of viral infection and degree of inflammatory response. Apoptotic cell death occurred in both infected and non-infected neurons. Interferon-a, which is a microglial activator, was also expressed by both. Tumour Necrosis Factor-a, inducible nitric oxide synthase and nitrotyrosine were expressed by microglial cells, astrocytes and macrophages. The same cells expressed matrix metalloproteinase (MMP)-2 whilst MMP-9 was expressed by neurons.
Conclusions/Significance: The results are consistent with JEV inducing neuronal apoptotic death and release of cytokines that initiate microglial activation and release of pro-inflammatory and apoptotic mediators with subsequent apoptotic death of both infected and uninfected neurons. Activation of astrocytes, microglial and endothelial cells likely contributes to inflammatory cell recruitment and BBB breakdown. It appears that neuronal apoptotic death and activation of microglial cells and astrocytes play a crucial role in the pathogenesis of JE.
C1 [Myint, Khin Saw Aye; Jarman, Richard G.; Gibbons, Robert V.; Mongkolsirichaikul, Duangrat; Van Gessel, Yvonne] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand.
[Myint, Khin Saw Aye; Solomon, Tom] Univ Liverpool, Inst Infect & Global Hlth, NIHR Hlth Protect Res Unit Emerging & Zoonot Infe, Brain Infect Grp, Liverpool L69 3BX, Merseyside, England.
[Myint, Khin Saw Aye; Solomon, Tom] Univ Liverpool, Walton Ctr NHS Fdn Trust, Liverpool L69 3BX, Merseyside, England.
[Kipar, Anja] Univ Liverpool, Sch Vet Sci, Liverpool L69 3BX, Merseyside, England.
[Kipar, Anja] Univ Liverpool, Dept Infect Biol, Inst Global Hlth, Liverpool L69 3BX, Merseyside, England.
[Perng, Guey Chuen] Emory Univ, Sch Med, Emory Vaccine Ctr, Atlanta, GA USA.
[Perng, Guey Chuen] Natl Cheng Kung Univ, Coll Med, Dept Microbiol & Immunol, Tainan 70101, Taiwan.
[Perng, Guey Chuen] Natl Cheng Kung Univ, Ctr Infect Dis & Signal Res, Tainan 70101, Taiwan.
[Flanagan, Brian] Univ Liverpool, Dept Clin Infect Microbiol & Immunol, Inst Infect & Global Hlth, Liverpool L69 3BX, Merseyside, England.
RP Myint, KSA (reprint author), Eijkman Inst, Emerging Virus Res Lab, Jakarta, Indonesia.
EM tsolomon@liverpool.ac.uk
RI Kipar, Anja/L-7214-2014;
OI Perng, Oscar/0000-0001-7510-4486; Solomon, Tom/0000-0001-7266-6547
FU U.S. Army Medical Research and Materiel Command
FX This work was supported by the U.S. Army Medical Research and Materiel
Command. The funders had no role in study design, data collection and
analysis, decision to publish, or preparation of the manuscript.
NR 42
TC 10
Z9 11
U1 1
U2 7
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1935-2735
J9 PLOS NEGLECT TROP D
JI Plos Neglect. Trop. Dis.
PD AUG
PY 2014
VL 8
IS 8
AR e2980
DI 10.1371/journal.pntd.0002980
PG 11
WC Infectious Diseases; Parasitology; Tropical Medicine
SC Infectious Diseases; Parasitology; Tropical Medicine
GA AO8AN
UT WOS:000341574700003
PM 25102067
ER
PT J
AU Whitehorn, J
Yacoub, S
Anders, KL
Macareo, LR
Cassetti, MC
Van, VCN
Shi, PY
Wills, B
Simmons, CP
AF Whitehorn, James
Yacoub, Sophie
Anders, Katherine L.
Macareo, Louis R.
Cassetti, M. Cristina
Vinh Chau Nguyen Van
Shi, Pei-Yong
Wills, Bridget
Simmons, Cameron P.
TI Dengue Therapeutics, Chemoprophylaxis, and Allied Tools: State of the
Art and Future Directions
SO PLOS NEGLECTED TROPICAL DISEASES
LA English
DT Review
ID PLACEBO-CONTROLLED TRIAL; RANDOMIZED CONTROLLED-TRIAL; VIRUS-INFECTION;
SHOCK SYNDROME; SEVERE THROMBOCYTOPENIA; PLATELET TRANSFUSION;
DOUBLE-BLIND; ENDOTHELIAL FUNCTION; PROTECTIVE EFFICACY;
FALCIPARUM-MALARIA
AB Dengue is the most common arboviral disease of humans. There is an unmet need for a therapeutic intervention that reduces the duration and severity of dengue symptoms and diminishes the likelihood of severe complications. To this end, there are active discovery efforts in industry and academia to develop interventions, with a focus on small molecule inhibitors of dengue virus replication that are suitable for therapy or chemoprophylaxis. Advancements in animal models of dengue virus infection together with the possibility of a dengue human infection model have further enhanced the platform for dengue drug discovery. Whilst drug discovery efforts gestate, there are ongoing clinical research designed to benefit today's patients, including trials of supportive care interventions, and descriptive studies that should improve the ability of clinicians to make an accurate diagnosis early in the illness course and to identify patients most at risk of progression to severe disease. This review provides a state of the art summary of dengue drug discovery, clinical trials, and supportive allied research and reflects discussions at the 2nd International Dengue Therapeutics Workshop held in Ho Chi Minh City, Vietnam, in December 2013.
C1 [Whitehorn, James] London Sch Hyg & Trop Med, Dept Clin Res, London WC1, England.
[Whitehorn, James; Yacoub, Sophie; Anders, Katherine L.; Wills, Bridget; Simmons, Cameron P.] Univ Oxford, Clin Res Unit, Hosp Trop Dis, Ho Chi Minh City, Vietnam.
[Yacoub, Sophie] Univ London Imperial Coll Sci Technol & Med, Dept Med, London, England.
[Macareo, Louis R.] US Army Med Component, Armed Forces Res Inst Med Sci, Bangkok, Thailand.
[Cassetti, M. Cristina] NIAID, Bethesda, MD 20892 USA.
[Vinh Chau Nguyen Van] Hosp Trop Dis, Ho Chi Minh City, Vietnam.
[Shi, Pei-Yong] Novartis Inst Trop Dis, Singapore, Singapore.
[Wills, Bridget; Simmons, Cameron P.] Univ Oxford, Ctr Trop Med, Oxford, England.
[Simmons, Cameron P.] Univ Melbourne, Dept Microbiol & Immunol, Parkville, Vic 3052, Australia.
RP Whitehorn, J (reprint author), London Sch Hyg & Trop Med, Dept Clin Res, London WC1, England.
EM csimmons@oucru.org
OI Simmons, Cameron P./0000-0002-9039-7392
FU Wellcome Trust of the United Kingdom [097430/Z/11/Z, 100562/Z/12/Z];
National Health and Medical Research Council, Australia (NHMRC)
[1047282]; National Medical Research Council in Singapore
FX JW and SY are supported by fellowships from the Wellcome Trust of the
United Kingdom (grants 097430/Z/11/Z and 100562/Z/12/Z respectively).
CPS is supported by the National Health and Medical Research Council,
Australia (NHMRC ID: 1047282). PYS was partially supported by the TCR
flagship "STOP Dengue'' program from National Medical Research Council
in Singapore. The funders had no role in study design, data collection
and analysis, decision to publish, or preparation of the manuscript.
NR 71
TC 17
Z9 18
U1 0
U2 11
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1935-2735
J9 PLOS NEGLECT TROP D
JI Plos Neglect. Trop. Dis.
PD AUG
PY 2014
VL 8
IS 8
AR e3025
DI 10.1371/journal.pntd.0003025
PG 6
WC Infectious Diseases; Parasitology; Tropical Medicine
SC Infectious Diseases; Parasitology; Tropical Medicine
GA AO8AN
UT WOS:000341574700018
PM 25166493
ER
PT J
AU Carbone, JW
Pasiakos, SM
Vislocky, LM
Anderson, JM
Rodriguez, NR
AF Carbone, John W.
Pasiakos, Stefan M.
Vislocky, Lisa M.
Anderson, Jeffrey M.
Rodriguez, Nancy R.
TI Effects of short-term energy deficit on muscle protein breakdown and
intramuscular proteolysis in normal-weight young adults
SO APPLIED PHYSIOLOGY NUTRITION AND METABOLISM-PHYSIOLOGIE APPLIQUEE
NUTRITION ET METABOLISME
LA English
DT Article
DE proteolysis; ubiquitin; weight loss; caspase-3; aerobic exercise; energy
deficit; fractional breakdown rate
ID GASTRIC-CANCER PATIENTS; INCREASED LEUCINE FLUX; HUMAN SKELETAL-MUSCLE;
FAT-FREE MASS; ENDURANCE EXERCISE; DIETARY-PROTEIN; POSTMENOPAUSAL
WOMEN; RESISTANCE EXERCISE; PROTEASOME ACTIVITY; BODY-COMPOSITION
AB The effects of short-term energy deficit (ED) on direct measures of muscle proteolysis and the intracellular mechanisms by which muscle proteins are degraded at rest and following aerobic exercise are not well described. This study evaluated the effects of a short-term diet-induced ED, on muscle fractional breakdown rate (FBR), intramuscular 26S proteasome activity, caspase-3 activation, and PSMA2 and MAFbx expression at rest, in the postabsorptive state, and following a single bout of moderate aerobic exercise (45 min at 65% peak oxygen uptake). Six men and 4 women participated in two 10-day diet interventions: weight maintenance (WM) followed by ED (80% estimated energy requirements). Dietary protein (1.5 g.kg(-1).day(-1)) intake was constant for WM and ED. Mixed muscle FBR, proteasome activity, and intracellular proteolytic factor expression were measured using stable isotope methodology, fluorescent enzyme activity assays, and Western blotting, respectively. Overall, FBR and caspase-3 activation increased 60% and 11%, respectively, in response to ED (P < 0.05), but were not influenced by exercise. During ED, 26S proteasome alpha-subunit PSMA2 expression was 25% higher (P < 0.05) after exercise compared with rest. Exercise did not influence PSMA2 expression during WM, and MAFbx expression and 26S proteasome activity were not affected by ED or exercise. These data illustrate the effects of short-term, moderate ED on muscle protein degradation. In the context of skeletal muscle integrity during weight loss interventions, this work demonstrates a need for further investigations aimed at mitigating muscle loss associated with energy deficit imposed for intentional reduction of total body weight.
C1 [Carbone, John W.] Eastern Michigan Univ, Sch Hlth Sci, Ypsilanti, MI 48197 USA.
[Pasiakos, Stefan M.] US Army, Environm Med Res Inst, Natick, MA 01760 USA.
[Vislocky, Lisa M.; Rodriguez, Nancy R.] Univ Connecticut, Dept Nutr Sci, Storrs, CT 06269 USA.
[Anderson, Jeffrey M.] Univ Connecticut, Dept Kinesiol, Storrs, CT 06269 USA.
RP Carbone, JW (reprint author), Eastern Michigan Univ, Sch Hlth Sci, 312 Marshall Bldg, Ypsilanti, MI 48197 USA.
EM jcarbon2@emich.edu
RI Pasiakos, Stefan/E-6295-2014
OI Pasiakos, Stefan/0000-0002-5378-5820
NR 59
TC 3
Z9 3
U1 0
U2 7
PU CANADIAN SCIENCE PUBLISHING, NRC RESEARCH PRESS
PI OTTAWA
PA 65 AURIGA DR, SUITE 203, OTTAWA, ON K2E 7W6, CANADA
SN 1715-5312
EI 1715-5320
J9 APPL PHYSIOL NUTR ME
JI Appl. Physiol. Nutr. Metab.
PD AUG
PY 2014
VL 39
IS 8
BP 960
EP 968
DI 10.1139/apnm-2013-0433
PG 9
WC Nutrition & Dietetics; Physiology; Sport Sciences
SC Nutrition & Dietetics; Physiology; Sport Sciences
GA AO7VC
UT WOS:000341559700013
PM 24945715
ER
PT J
AU Wang, D
Abdelzaher, T
Kaplan, L
AF Wang, Dong
Abdelzaher, Tarek
Kaplan, Lance
TI Surrogate Mobile Sensing
SO IEEE COMMUNICATIONS MAGAZINE
LA English
DT Article
AB The proliferation of smart phones with sensing capabilities motivates exploring the applicability limits of (phone-based) mobile sensing. While a phone can directly measure variables such as location, acceleration, and orientation, other interesting quantities one may want to measure have higher-level semantics that a phone does not directly recognize. For example, one might want to map parking lots that are free after hours, or restaurants that are popular after midnight. How can we measure such higher-level logical quantities using sensors on phones? Techniques that address this question fall in the broad area of surrogate sensing, defined as inferring high-level logical quantities by measuring weaker surrogates. The surrogates in question are variables that can be sensed using a phone, but are only weakly related to the original high-level logical quantities one is really after. The key challenge is to exploit appropriate aggregation techniques that leverage the availability of large numbers of phones to overcome the poor quality of individual surrogates. Recently, significant advances have been made in understanding the quality limits of surrogate sensing. This article overviews the main ideas and insights underlying these advances.
C1 [Wang, Dong] Univ Notre Dame, Notre Dame, IN 46556 USA.
[Abdelzaher, Tarek] Univ Illinois, Urbana, IL USA.
[Kaplan, Lance] US Army, Res Lab, Kansas City, KS USA.
RP Wang, D (reprint author), Univ Notre Dame, Dept Comp Sci & Engn, Notre Dame, IN 46556 USA.
EM zaher@cs.uiuc.edu
FU Army Research Laboratory [W911NF-09-2-0053]; DTRA [HDTRA1-10-1-0120];
NSF [CNS 10-59294, CNS 10-35736]
FX Research reported in this article was sponsored by the Army Research
Laboratory and was accomplished under Cooperative Agreement
W911NF-09-2-0053, DTRA grant HDTRA1-10-1-0120, and NSF grants CNS
10-59294 and CNS 10-35736. The views and conclusions contained in this
document are those of the authors and should not be interpreted as
representing the official policies, either expressed or implied, of the
Army Research Laboratory or the U.S. Government. The U.S. Government is
authorized to reproduce and distribute reprints for Government purposes
notwithstanding any copyright notation here on.
NR 12
TC 8
Z9 8
U1 0
U2 7
PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
PI PISCATAWAY
PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA
SN 0163-6804
EI 1558-1896
J9 IEEE COMMUN MAG
JI IEEE Commun. Mag.
PD AUG
PY 2014
VL 52
IS 8
BP 36
EP 41
PG 6
WC Engineering, Electrical & Electronic; Telecommunications
SC Engineering; Telecommunications
GA AO7IX
UT WOS:000341527800005
ER
PT J
AU Lawson, K
Bayne, SB
Lacouture, S
Cheng, L
O'Brien, H
Ogunniyi, A
Scozzie, C
AF Lawson, Kevin
Bayne, Stephen B.
Lacouture, Shelby
Cheng, Lin
O'Brien, Heather
Ogunniyi, Aderinto
Scozzie, Charles
TI Safe Operating Area and Long-Term Reliability of 9-kV Silicon Carbide
PNPN Super Gate Turn-Off Thyristors
SO IEEE ELECTRON DEVICE LETTERS
LA English
DT Article
DE Electronic devices; life testing; semiconductor devices; semiconductor
device reliability; semiconductor device testing; SGTO; silicon carbide;
safe operating area; power semiconductor switches; thyristors; wide band
gap semiconductors
ID DEVICES
AB One of the major requirements for adoption of new silicon carbide (SiC) super gate turn-off thyristors (SGTOs) into high-energy applications is to verify the safe operating area and long-term reliability capabilities of these devices. In this letter, we have developed a unique high-energy testing system that can evaluate the performance limitations with respect to lifetime capabilities of the 9 kV, 1 cm(2), SGTOs at ultrahigh pulsed current levels from 1 to 3.5 kA. The test system produces square current pulses with a user specified current amplitude and a 100-mu s pulsewidth at a maximum repetition rate of 1 shot/s (>0.1% duty cycle). A lifetime safe operating area with respect to maximum pulsed current was then established that these 1 cm(2), 9 kV, SiC SGTOs can perform reliably without significant degradation at pulsed current levels up to 2.0 kA. At current levels above 2.0 kA shifts in the on-state voltage are observed probably due to device over-heating at such high current levels and having not enough time to fully dissipate the heat between any two shots, which results in the device rapidly deteriorating due to increased on-state losses ultimately leading to premature failure.
C1 [Lawson, Kevin; Bayne, Stephen B.; Lacouture, Shelby] Texas Tech Univ, Ctr Pulsed Power & Power Elect, Lubbock, TX 79409 USA.
[Cheng, Lin] Cree Inc, Durham, NC 27703 USA.
[O'Brien, Heather; Ogunniyi, Aderinto; Scozzie, Charles] US Army, Res Lab, Adelphi, MD 20783 USA.
RP Lawson, K (reprint author), Texas Tech Univ, Ctr Pulsed Power & Power Elect, Lubbock, TX 79409 USA.
EM kevin.lawson@ttu.edu
FU U.S. Army Research Laboratory, Adelphi, MD, USA
FX This work was supported by the U.S. Army Research Laboratory, Adelphi,
MD, USA. The review of this letter was arranged by Editor W. T. Ng.
NR 11
TC 6
Z9 6
U1 0
U2 14
PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
PI PISCATAWAY
PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA
SN 0741-3106
EI 1558-0563
J9 IEEE ELECTR DEVICE L
JI IEEE Electron Device Lett.
PD AUG
PY 2014
VL 35
IS 8
BP 862
EP 864
DI 10.1109/LED.2014.2329795
PG 3
WC Engineering, Electrical & Electronic
SC Engineering
GA AO7ZY
UT WOS:000341573000018
ER
PT J
AU Pulskamp, JS
Bedair, SS
Polcawich, RG
Meyer, CD
Kierzewski, I
Maack, B
AF Pulskamp, Jeffrey S.
Bedair, Sarah S.
Polcawich, Ronald G.
Meyer, Christopher D.
Kierzewski, Iain
Maack, Bryan
TI High-Q and Capacitance Ratio Multilayer Metal-on-Piezoelectric RF MEMS
Varactors
SO IEEE ELECTRON DEVICE LETTERS
LA English
DT Article
DE Microelectromechanical devices; microwave devices; capacitors; tunable
devices; piezoelectric devices
ID ACTUATION
AB This letter documents the design and characterization of integrated and continuously tuned, radio frequency multilayer metal noncontact varactors with low-power, large-displacement, thin-film lead zirconate titanate (PZT) actuators. The devices, with capacitances in the 0.019-0.23-pF range, achieved high quality factors at the maximum capacitance state (Q = 100 at 8.7 GHz) and tuning ratios as high as 11.6: 1 at 20 V actuation with nW-power consumption. The devices utilize three electroplated copper (Cu) layers (similar to 10 mu m per layer) directly fabricated on PZT microelectromechanical system actuators.
C1 [Pulskamp, Jeffrey S.; Bedair, Sarah S.; Polcawich, Ronald G.; Meyer, Christopher D.; Kierzewski, Iain; Maack, Bryan] US Army, Res Lab, Adelphi, MD 20783 USA.
RP Pulskamp, JS (reprint author), US Army, Res Lab, Adelphi, MD 20783 USA.
EM jeffrey.s.pulskamp.civ@mail.mil
NR 16
TC 4
Z9 4
U1 0
U2 12
PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
PI PISCATAWAY
PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA
SN 0741-3106
EI 1558-0563
J9 IEEE ELECTR DEVICE L
JI IEEE Electron Device Lett.
PD AUG
PY 2014
VL 35
IS 8
BP 871
EP 873
DI 10.1109/LED.2014.2327611
PG 3
WC Engineering, Electrical & Electronic
SC Engineering
GA AO7ZY
UT WOS:000341573000021
ER
PT J
AU Brungart, DS
Sheffield, BM
Kubli, LR
AF Brungart, Douglas S.
Sheffield, Benjamin M.
Kubli, Lina R.
TI Development of a test battery for evaluating speech perception in
complex listening environments
SO JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA
LA English
DT Article
ID HEARING-IMPAIRED SUBJECTS; IN-NOISE TEST; ARTICULATION INDEX; CONSONANT
RECOGNITION; INTELLIGIBILITY; TALKERS; MASKING; BENEFIT
AB In the real world, spoken communication occurs in complex environments that involve audiovisual speech cues, spatially separated sound sources, reverberant listening spaces, and other complicating factors that influence speech understanding. However, most clinical tools for assessing speech perception are based on simplified listening environments that do not reflect the complexities of real-world listening. In this study, speech materials from the QuickSIN speech-in-noise test by Killion, Niquette, Gudmundsen, Revit, and Banerjee [J. Acoust. Soc. Am. 116, 2395-2405 (2004)] were modified to simulate eight listening conditions spanning the range of auditory environments listeners encounter in everyday life. The standard QuickSIN test method was used to estimate 50% speech reception thresholds (SRT50) in each condition. A method of adjustment procedure was also used to obtain subjective estimates of the lowest signal-to-noise ratio (SNR) where the listeners were able to understand 100% of the speech (SRT100) and the highest SNR where they could detect the speech but could not understand any of the words (SRT0). The results show that the modified materials maintained most of the efficiency of the QuickSIN test procedure while capturing performance differences across listening conditions comparable to those reported in previous studies that have examined the effects of audiovisual cues, binaural cues, room reverberation, and time compression on the intelligibility of speech.
C1 [Brungart, Douglas S.; Sheffield, Benjamin M.; Kubli, Lina R.] Walter Reed Natl Mil Med Ctr, Bethesda, MD 20889 USA.
[Sheffield, Benjamin M.; Kubli, Lina R.] US Army Publ Hlth Command, Bethesda, MD 20889 USA.
RP Brungart, DS (reprint author), Walter Reed Natl Mil Med Ctr, 8901 Wisconsin Ave, Bethesda, MD 20889 USA.
EM douglas.s.brungart.civ@health.mil
FU Army Hearing Program; Defense Medical Research and Development Program
[D61_I_10_J8_261]
FX Portions of this work were funded by the Army Hearing Program and a
grant from Defense Medical Research and Development Program (Proposal
Number D61_I_10_J8_261). The views expressed in this article are those
of the authors and do not necessarily reflect the official policy or
position of the Department of the Army, the Department of the Navy, the
Department of the Air Force, the Department of Defense, nor the U.S.
Government.
NR 22
TC 2
Z9 2
U1 1
U2 14
PU ACOUSTICAL SOC AMER AMER INST PHYSICS
PI MELVILLE
PA STE 1 NO 1, 2 HUNTINGTON QUADRANGLE, MELVILLE, NY 11747-4502 USA
SN 0001-4966
EI 1520-8524
J9 J ACOUST SOC AM
JI J. Acoust. Soc. Am.
PD AUG
PY 2014
VL 136
IS 2
BP 777
EP 790
DI 10.1121/1.4887440
PG 14
WC Acoustics; Audiology & Speech-Language Pathology
SC Acoustics; Audiology & Speech-Language Pathology
GA AO2TE
UT WOS:000341178100055
PM 25096112
ER
PT J
AU Carlson, LA
Ferguson, DP
Kenefick, RW
AF Carlson, Lara A.
Ferguson, David P.
Kenefick, Robert W.
TI Physiological strain of stock car drivers during competitive racing
SO JOURNAL OF THERMAL BIOLOGY
LA English
DT Article
DE Thermoregulation; Motorsports athletes; NASCAR; Speedway
ID HEAT-STRESS; UNCOMPENSABLE HEAT; BLOOD-PRESSURE; STROKE VOLUME;
PERFORMANCE; RESPONSES; BODY; ACCELERATION; HYPERTHERMIA; TEMPERATURE
AB Heat strain experienced by motorsport athletes competing in National Association for Stock Car Automobile Racing (NASCAR) may be significant enough to impair performance or even result in a life-threatening accident. There is a need to carefully quantify heat strain during actual NASCAR race competitions in order to faithfully represent the magnitude of the problem and conceptualize future mitigation practices. The purpose of this investigation was to quantify the thermoregulatory and physiological strain associated with competitive stock car driving. Eight male stock car drivers (29.0 +/- 10.0 yr; 176.2 +/- 3.3 cm, 80.6 +/- 15.7 kg) participated in sanctioned stock car races. Physiological measurements included intestinal core (T-c) and skin (T-sk) temperatures, heart rate (HR), blood pressure, and body mass before and after completion of the race. Pre-race T-c was 38.1 +/- 0.1 degrees C which increased to 38.6 +/- 0.2 degrees C post-race (p=0.001). T-sk increased from 36.1 +/- 0.2 degrees C pre-race to 37.3 +/- 0.3 degrees C post-race (p=0.001) whereas the core-to-skin temperature gradient decreased from a pre-race value of 2.0 +/- 0.3 degrees C to 1.3 +/- 0.3 degrees C post-race (p=0.005). HRs post-race were 80 +/- 0.1% of the drivers' age-predicted maximum HR. Physiological Strain Index (PSI) post-race was 4.9, which indicates moderate strain. Drivers' thermal sensation based on the ASHRAE Scale increased from 1.3 +/- 0.5 to 2.8 +/- 0.4, and their perception of exertion (RPE) responses also increased from 8.4 +/- 1.6 to 13.9 +/- 1.8 after competition. Heat strain associated with competitive stock car racing is significant. These findings suggest the need for heat mitigation practices and provide evidence that motorsport should consider strategies to become heat acclimatized to better meet the thermoregulatory and cardiovascular challenges of motorsport competition. (C) 2014 Elsevier Ltd. All rights reserved.
C1 [Carlson, Lara A.] Univ New England, Biddeford, ME 04005 USA.
[Ferguson, David P.] Baylor Coll Med, Childrens Nutr Res Ctr, Houston, TX 77030 USA.
[Kenefick, Robert W.] US Army, Environm Med Res Inst, Natick, MA 01760 USA.
RP Carlson, LA (reprint author), Univ New England, 11 Hills Beach Rd, Biddeford, ME 04005 USA.
EM lcarlson@une.edu; David.Ferguson@bcm.edu; Robert.Kenefick@us.army.mil
NR 35
TC 1
Z9 1
U1 1
U2 10
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4565
J9 J THERM BIOL
JI J. Therm. Biol.
PD AUG
PY 2014
VL 44
BP 20
EP 26
DI 10.1016/j.jtherbio.2014.06.001
PG 7
WC Biology; Zoology
SC Life Sciences & Biomedicine - Other Topics; Zoology
GA AO6QZ
UT WOS:000341477900004
PM 25086969
ER
PT J
AU Najmaei, S
Amani, M
Chin, ML
Liu, Z
Birdwell, AG
O'Regan, TP
Ajayan, PM
Dubey, M
Lou, J
AF Najmaei, Sina
Amani, Matin
Chin, Matthew L.
Liu, Zheng
Birdwell, A. Glen
O'Regan, Terrance P.
Ajayan, Pulickel M.
Dubey, Madan
Lou, Jun
TI Electrical Transport Properties of Polycrystalline Monolayer Molybdenum
Disulfide
SO ACS NANO
LA English
DT Article
DE two-dimensional materials; MoS2; polycrystallinity; grain boundaries;
electronic transport
ID CHEMICAL-VAPOR-DEPOSITION; FIELD-EFFECT TRANSISTORS; MOS2 ATOMIC LAYERS;
GRAIN-BOUNDARIES; LARGE-AREA; VALLEY POLARIZATION; PHASE GROWTH;
GRAPHENE; FILMS
AB Semiconducting MoS2 monolayers have shown many promising electrical properties, and the inevitable polycrystallinity in synthetic, large-area films renders understanding the effect of structural defects, such as grain boundaries (GBs, or line-defects in two-dimensional materials), essential. In this work, we first examine the role of GBs in the electrical transport properties of MoS2 monolayers with varying line-defect densities. We reveal a systematic degradation of electrical characteristics as the line-defect density increases. The two common MoS2 GB types and their specific roles are further examined, and we find that only tilt GBs have a considerable effect on the MoS2 electrical properties. By examining the electronic states and sources of disorder using temperature-dependent transport studies, we adopt the Anderson model for disordered systems to explain the observed transport behaviors in different temperature regimes. Our results elucidate the roles played by GBs in different scenarios and give insights into their underlying scattering mechanisms.
C1 [Najmaei, Sina; Liu, Zheng; Ajayan, Pulickel M.; Lou, Jun] Rice Univ, Dept Mat Sci & NanoEngn, Houston, TX 77005 USA.
[Amani, Matin; Chin, Matthew L.; Birdwell, A. Glen; O'Regan, Terrance P.; Dubey, Madan] US Army Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20723 USA.
RP Dubey, M (reprint author), US Army Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20723 USA.
EM jlou@rice.edu
RI Liu, Zheng/C-1813-2014
OI Liu, Zheng/0000-0002-8825-7198
FU Welch Foundation [C-1716]; NSF [DMR-1327093]; U.S. Army Research Office
(MURI) [W911NF-11-1-0362]; U.S. Office of Naval Research (MURI)
[N000014-09-1-1066]; Nanoelectronics Research Corporation [S201006];
National Science Foundation [DMR-0938330]; Singapore National Research
Foundation under NRF RF [NRF-RF2013-08]; Nanyang Technological
University [M4081137.070]
FX This work was supported by the Welch Foundation (Grant No. C-1716), the
NSF (Grant No. DMR-1327093), the U.S. Army Research Office (MURI Grant
No. W911NF-11-1-0362), the U.S. Office of Naval Research (MURI Grant No.
N000014-09-1-1066), and the Nanoelectronics Research Corporation
contract S201006. This research was also supported in part by the
National Science Foundation through Grant No. DMR-0938330. M.D., M.A.,
M.L.C., A.G.B., and T.P.O. acknowledge the support of the ARL Director's
Strategic Initiative (DSI) program on interfaces in stacked 2D atomic
layered materials. The authors would also like to thank Dr. Pani
Varanasi, ARO for his in-depth technical discussion on 2D atomic layer
R&D. The views and conclusions contained in this document are those of
the authors and should not be interpreted as representing the official
policies, either expressed or implied, of the ARL or the U.S. Government
This work was also supported by the Singapore National Research
Foundation under NRF RF Award No. NRF-RF2013-08, the start-up funding
from Nanyang Technological University (M4081137.070).
NR 28
TC 28
Z9 28
U1 9
U2 121
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 1936-0851
EI 1936-086X
J9 ACS NANO
JI ACS Nano
PD AUG
PY 2014
VL 8
IS 8
BP 7930
EP 7937
DI 10.1021/nn501701a
PG 8
WC Chemistry, Multidisciplinary; Chemistry, Physical; Nanoscience &
Nanotechnology; Materials Science, Multidisciplinary
SC Chemistry; Science & Technology - Other Topics; Materials Science
GA AO0IM
UT WOS:000340992300038
PM 25019978
ER
PT J
AU Kellicut, DC
Kuncir, EJ
Williamson, HM
Masella, PC
Nielsen, PE
AF Kellicut, Dwight C.
Kuncir, Eric J.
Williamson, Hope M.
Masella, Pamela C.
Nielsen, Peter E.
TI Surgical Team Assessment Training: improving surgical teams during
deployment
SO AMERICAN JOURNAL OF SURGERY
LA English
DT Article
DE Simulation; Trauma training; TeamSTEPPS
ID OPERATING-ROOM; COMMUNICATION; CARE; COLLABORATION; DELIVERY; AVIATION;
OUTCOMES; SAFETY; TRIAL
AB BACKGROUND: Simulation and team training are accepted as critical patient safety strategies to improve team performance and can help achieve better outcomes. Standardized and realistic drills conducted by skilled physicians and nurses who demonstrate consistent use of principles which enhance communication and teamwork increase the likelihood of improved clinical outcomes.
METHODS: Two, 4-member surgeon/nurse teams traveled to 8 Army surgical resuscitation medical treatment facilities in Iraq during July and August 2011. At each site, a new program called Surgical Team Assessment Training was introduced and implemented to 220 military personnel. Two multi-patient scenarios were designed to test resuscitative and operating room medical decision-making, communication, and co-ordination of care. In addition, 2 hours of didactic instruction emphasized principles of TeamSTEPPS applied to emergency and operating rooms during care of patients with multiple, complex traumatic injuries. Anonymous surveys were completed by participants following the training.
RESULTS: Participants were significantly more likely to rate this training as very helpful following training compared with their opinion before participation (53% vs 37%, P < .05). Seventy-seven percent felt that it would improve overall patient outcomes, 78% said it would likely contribute to saving lives in combat, and 98% felt it should be provided to military Emergency Medicine and Surgical residents.
CONCLUSIONS: Surgical Team Assessment Training can be successfully implemented in an austere, hostile environment and improve trauma team function by incorporating simulation training models and TeamSTEPPs concepts. Expansion of this program for predeployment and resident training is currently under investigation based on the extremely positive responses. Published by Elsevier Inc.
C1 [Kellicut, Dwight C.; Masella, Pamela C.] Tripler Army Med Ctr, Honolulu, HI 96859 USA.
[Kuncir, Eric J.] Naval Med Ctr San Diego, San Diego, CA USA.
[Williamson, Hope M.] 86th Combat Support Hosp, Ft Campbell, KY USA.
[Nielsen, Peter E.] Madigan Army Med Ctr, Tacoma, WA 98431 USA.
RP Kellicut, DC (reprint author), Tripler Army Med Ctr, 1 Jarrett White Rd, Honolulu, HI 96859 USA.
EM dwight.c.kellicut.mil@mail.mil
OI Kuncir, Eric/0000-0001-6548-8308
NR 19
TC 3
Z9 3
U1 1
U2 10
PU EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC
PI BRIDGEWATER
PA 685 ROUTE 202-206 STE 3, BRIDGEWATER, NJ 08807 USA
SN 0002-9610
EI 1879-1883
J9 AM J SURG
JI Am. J. Surg.
PD AUG
PY 2014
VL 208
IS 2
BP 275
EP 283
DI 10.1016/j.amjsurg.2014.03.008
PG 9
WC Surgery
SC Surgery
GA AO2KC
UT WOS:000341149400019
PM 24946726
ER
PT J
AU Ma, L
He, T
Leung, KK
Swami, A
Towsley, D
AF Ma, Liang
He, Ting
Leung, Kin K.
Swami, Ananthram
Towsley, Don
TI Inferring Link Metrics From End-To-End Path Measurements:
Identifiability and Monitor Placement
SO IEEE-ACM TRANSACTIONS ON NETWORKING
LA English
DT Article
DE Identifiability condition; linear algebraic model; monitor placement;
network tomography
ID NETWORK TOMOGRAPHY; DELAY; INFERENCE
AB We investigate the problem of identifying individual link metrics in a communication network from end-to-end path measurements, under the assumption that linkmetrics are additive and constant. To uniquely identify the link metrics, the number of linearly independent measurement paths must equal the number of links. Our contribution is to characterize this condition in terms of the network topology and the number/placement of monitors, under the constraint that measurement paths must be cycle-free. Our main results are: 1) it is generally impossible to identify all the link metrics by using two monitors; 2) nevertheless, metrics of all the interior links not incident to any monitor are identifiable by two monitors if the topology satisfies a set of necessary and sufficient connectivity conditions; 3) these conditions naturally extend to a necessary and sufficient condition for identifying all the link metrics using three or more monitors. We show that these conditions not only facilitate efficient identifiability tests, but also enable an efficient algorithm to place the minimum number of monitors in order to identify all link metrics. Our evaluations on both random and real topologies show that the proposed algorithm achieves identifiability using a much smaller number of monitors than a baseline solution.
C1 [Ma, Liang; Leung, Kin K.] Univ London Imperial Coll Sci Technol & Med, London SW7 2BT, England.
[He, Ting] IBM TJ Watson Res Ctr, Yorktown Hts, NY 10598 USA.
[Swami, Ananthram] Army Res Lab, Adelphi, MD 20783 USA.
[Towsley, Don] Univ Massachusetts, Amherst, MA 01003 USA.
RP Ma, L (reprint author), Univ London Imperial Coll Sci Technol & Med, London SW7 2BT, England.
EM l.ma10@imperial.ac.uk; the@us.ibm.com; kin.leung@imperial.ac.uk;
a.swami@ieee.org; towsley@cs.umass.edu
FU U.S. Army Research Laboratory; U.K. Ministry of Defence
[W911NF-06-3-0001]
FX This work was supported in part by the U.S. Army Research Laboratory and
the U.K. Ministry of Defence and was accomplished under Agreement No.
W911NF-06-3-0001. The views and conclusions contained in this document
are those of the authors and should not be interpreted as representing
the official policies, either expressed or implied, of the U.S. Army
Research Laboratory, the U.S. Government, the U.K. Ministry of Defence,
or the U.K. Government. The U.S. and U.K. Governments are authorized to
reproduce and distribute reprints for Government purposes
notwithstanding any copyright notation hereon.
NR 39
TC 4
Z9 4
U1 0
U2 1
PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
PI PISCATAWAY
PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA
SN 1063-6692
EI 1558-2566
J9 IEEE ACM T NETWORK
JI IEEE-ACM Trans. Netw.
PD AUG
PY 2014
VL 22
IS 4
BP 1351
EP 1368
DI 10.1109/TNET.2014.2328668
PG 18
WC Computer Science, Hardware & Architecture; Computer Science, Theory &
Methods; Engineering, Electrical & Electronic; Telecommunications
SC Computer Science; Engineering; Telecommunications
GA AN9RA
UT WOS:000340944200025
ER
PT J
AU Toblin, RL
Quartana, PJ
Riviere, LA
Walper, KC
Hoge, CW
AF Toblin, Robin L.
Quartana, Phillip J.
Riviere, Lyndon A.
Walper, Kristina Clarke
Hoge, Charles W.
TI Chronic Pain and Opioid Use in US Soldiers After Combat Deployment
SO JAMA INTERNAL MEDICINE
LA English
DT Letter
C1 [Toblin, Robin L.; Quartana, Phillip J.; Riviere, Lyndon A.; Walper, Kristina Clarke; Hoge, Charles W.] Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci, Silver Spring, MD USA.
[Toblin, Robin L.] US PHS, Commissioned Corps, Rockville, MD USA.
RP Toblin, RL (reprint author), US PHS, Commissioned Corps, 503 Robert Grant Ave, Silver Spring, MD 20910 USA.
EM robin.l.toblin.mil@mail.mil
NR 6
TC 18
Z9 18
U1 0
U2 1
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA
SN 2168-6106
EI 2168-6114
J9 JAMA INTERN MED
JI JAMA Intern. Med.
PD AUG
PY 2014
VL 174
IS 8
BP 1400
EP 1401
DI 10.1001/jamainternmed.2014.2726
PG 3
WC Medicine, General & Internal
SC General & Internal Medicine
GA AN2WP
UT WOS:000340447000042
PM 24978399
ER
PT J
AU Jonas, WB
Schoomaker, EB
AF Jonas, Wayne B.
Schoomaker, Eric B.
TI Pain and Opioids in the Military: We Must Do Better
SO JAMA INTERNAL MEDICINE
LA English
DT Editorial Material
C1 [Jonas, Wayne B.] Samueli Inst, Alexandria, VA USA.
[Schoomaker, Eric B.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA.
RP Jonas, WB (reprint author), US Army, Samueli Inst, 1737 King St,Ste 600, Alexandria, VA 22314 USA.
EM wjonas@siib.org
NR 8
TC 3
Z9 3
U1 0
U2 0
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA
SN 2168-6106
EI 2168-6114
J9 JAMA INTERN MED
JI JAMA Intern. Med.
PD AUG
PY 2014
VL 174
IS 8
BP 1402
EP 1403
DI 10.1001/jamainternmed.2014.2114
PG 2
WC Medicine, General & Internal
SC General & Internal Medicine
GA AN2WP
UT WOS:000340447000043
PM 24978149
ER
PT J
AU Ingalls, N
Zonies, D
Bailey, JA
Martin, KD
Iddins, BO
Carlton, PK
Hanseman, D
Branson, R
Dorlac, W
Johannigman, J
AF Ingalls, Nichole
Zonies, David
Bailey, Jeffrey A.
Martin, Kathleen D.
Iddins, Bart O.
Carlton, Paul K.
Hanseman, Dennis
Branson, Richard
Dorlac, Warren
Johannigman, Jay
TI A Review of the First 10 Years of Critical Care Aeromedical Transport
During Operation Iraqi Freedom and Operation Enduring Freedom The
Importance of Evacuation Timing
SO JAMA SURGERY
LA English
DT Review
ID COMBAT CASUALTY CARE
AB IMPORTANCE Advances in the care of the injured patient are perhaps the only benefit of military conflict. One of the unique aspects of the military medical care system that emerged during Operation Iraqi Freedom and Operation Enduring Freedom has been the opportunity to apply existing civilian trauma system standards to the provision of combat casualty care across an evolving theater of operations.
OBJECTIVES To identify differences in mortality for soldiers undergoing early and rapid evacuation from the combat theater and to evaluate the capabilities of the Critical Care Air Transport Team (CCATT) and Joint Theater Trauma Registry databases to provide adequate data to support future initiatives for improvement of performance.
DESIGN, SETTING, AND PARTICIPANTS Retrospective review of CCATT records and the Joint Theater Trauma Registry from September 11, 2001, to December 31, 2010, for the in-theater military medicine health system, including centers in Iraq, Afghanistan, and Germany. Of 2899 CCATT transport records, those for 975 individuals had all the required data elements.
EXPOSURE Rapid evacuation by the CCATT.
MAIN OUTCOMES AND MEASURES Survival as a function of time from injury to arrival at the role IV facility at Landstuhl Regional Medical Center.
RESULTS The patient cohort demonstrated a mean Injury Severity Score of 23.7 and an overall 30-day mortality of 2.1%. Mortality en route was less than 0.02%. Statistically significant differences between survivors and decedents with respect to the Injury Severity Score (mean [SD], 23.4 [12.4] vs 37.7 [16.5]; P <.001), cumulative volume of blood transfused among the patients in each group who received a transfusion (P < .001), worst base deficit (mean [SD], -3.4 [5.0] vs -7.8 [6.9]; P = .02), and worst international normalized ratio (median [interquartile range], 1.2 [1.0-1.4] vs 1.4 [1.1-2.2]; P = .03) were observed. We found no statistically significant difference between survivors and decedents with respect to time from injury to arrival at definitive care.
CONCLUSIONS AND RELEVANCE Rapid movement of critically injured casualties within hours of wounding appears to be effective, with a minimal mortality incurred during movement and overall 30-day mortality. We found no association between the duration of time from wounding to arrival at Landstuhl Regional Medical Center with respect to mortality.
C1 [Ingalls, Nichole] Univ Nevada, Nellis AFB, Dept Surg, Las Vegas, NV 89154 USA.
[Zonies, David] Landsthul Reg Med Ctr, Crit Care Program, Kaiserslautern, Germany.
[Bailey, Jeffrey A.] US Army Inst Surg Res, Joint Trauma Syst, Ft Sam Houston, TX USA.
[Martin, Kathleen D.] Landstuhl Reg Med Ctr, Trauma Program, Kaiserslautern, Germany.
[Iddins, Bart O.] Headquarters Air Mobil Command, Scott AFB, IL USA.
[Carlton, Paul K.] US Dept HHS, Off Surg Gen, Washington, DC 20201 USA.
[Hanseman, Dennis; Branson, Richard; Dorlac, Warren; Johannigman, Jay] Univ Cincinnati, Dept Surg, Div Trauma & Crit Care, Cincinnati, OH 45267 USA.
RP Johannigman, J (reprint author), Univ Cincinnati, Dept Surg, Div Trauma & Crit Care, 231 Albert SabinWay,Mail Locat 0558, Cincinnati, OH 45267 USA.
EM jay.johannigman@uc.edu
FU Department of Surgery, University of Cincinnati
FX This study was supported by internal funding from the Department of
Surgery, University of Cincinnati.
NR 15
TC 15
Z9 15
U1 0
U2 5
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA
SN 2168-6254
EI 2168-6262
J9 JAMA SURG
JI JAMA Surg.
PD AUG
PY 2014
VL 149
IS 8
BP 807
EP 813
DI 10.1001/jamasurg.2014.621
PG 7
WC Surgery
SC Surgery
GA AN8DZ
UT WOS:000340834300013
PM 25074327
ER
PT J
AU Scott, AM
Burns, EA
Hill, FC
AF Scott, Andrea Michalkova
Burns, Elizabeth A.
Hill, Frances C.
TI Theoretical study of adsorption of nitrogen-containing environmental
contaminants on kaolinite surfaces
SO JOURNAL OF MOLECULAR MODELING
LA English
DT Article
DE Cluster models; M06-2X; Aqueous solution; Mineral
ID MINNESOTA DENSITY FUNCTIONALS; CLAY-MINERALS; NONCOVALENT INTERACTIONS;
AB-INITIO; SUBSTITUTED NITROBENZENES; NITROAROMATIC EXPLOSIVES;
THERMOCHEMICAL KINETICS; MECHANISMS; 1,3,5-TRINITROBENZENE;
2,4-DINITROTOLUENE
AB The adsorption of nitrogen-containing compounds (NCCs) including 2,4,6-trinitrotoluene (TNT), 2,4-dinitrotoluene (DNT), 2,4-dinitroanisole (DNAN), and 3-nitro-1,2,4-triazol-5-one (NTO) on kaolinite surfaces was investigated. The M06-2X and M06-2X-D3 density functionals were applied with the cluster approximation. Several different positions of NCCs relative to the adsorption sites of kaolinite were examined, including NCCs in perpendicular and parallel orientation toward both surface models of kaolinite. The binding between the target molecules and kaolinite surfaces was analyzed and bond energies were calculated applying the atoms in molecules (AIM) method. All NCCs were found to prefer a parallel orientation toward both kaolinite surfaces, and were bound more strongly to the octahedral than to the tetrahedral site. TNT exhibited the strongest interaction with the octahedral surface and DNAN with the tetrahedral surface of kaolinite. Hydrogen bonding was shown to be the dominant non-covalent interaction for NCCs interacting with the octahedral surface of kaolinite with a small stabilizing effect of dispersion interactions. In the case of adsorption on the tetrahedral surface, kaolonite-NCC binding was shown to be governed by the balance between hydrogen bonds and dispersion forces. The presence of water as a solvent leads to a significant decrease in the adsorption strength for all studied NCCs interacting with both kaolinite surfaces.
C1 [Scott, Andrea Michalkova; Hill, Frances C.] US Army Engn Res & Dev Ctr ERDC, Vicksburg, MS 39180 USA.
[Burns, Elizabeth A.] Badger Tech Serv LLC, Vicksburg, MS 39180 USA.
RP Scott, AM (reprint author), US Army Engn Res & Dev Ctr ERDC, Vicksburg, MS 39180 USA.
EM andrea.m.scott@usace.army.mil
FU High Performance Computing Major Shared Resource Center at the Engineer
Research and Development Center (ERDC, Vicksburg, MS); Environmental
Quality Technology Program of the United States Army Corps of Engineers,
US Army ERDC
FX This work was facilitated by support from the High Performance Computing
Major Shared Resource Center at the Engineer Research and Development
Center (ERDC, Vicksburg, MS). The use of trade, product, or firm names
in this report is for descriptive purposes only and does not imply
endorsement by the US Government. Results in this study were funded and
obtained from research conducted under the Environmental Quality
Technology Program of the United States Army Corps of Engineers by the
US Army ERDC. Permission was granted by the Chief of Engineers to
publish this information. The findings of this report are not to be
construed as an official Department of the Army position unless so
designated by other authorized documents.
NR 48
TC 4
Z9 4
U1 3
U2 25
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1610-2940
EI 0948-5023
J9 J MOL MODEL
JI J. Mol. Model.
PD AUG
PY 2014
VL 20
IS 8
AR 2373
DI 10.1007/s00894-014-2373-7
PG 13
WC Biochemistry & Molecular Biology; Biophysics; Chemistry,
Multidisciplinary; Computer Science, Interdisciplinary Applications
SC Biochemistry & Molecular Biology; Biophysics; Chemistry; Computer
Science
GA AN8QR
UT WOS:000340869400044
PM 25031081
ER
PT J
AU Balent, E
Edwards, M
Lustik, M
Martin, P
AF Balent, Eric
Edwards, Mary
Lustik, Michael
Martin, Paul
TI Caudal anesthesia with sedation for inguinal hernia repair in high risk
neonates
SO JOURNAL OF PEDIATRIC SURGERY
LA English
DT Article
DE Inguinal hernia; Neonate; Caudal; Regional
ID FRENCH-LANGUAGE SOCIETY; POSTOPERATIVE APNEA; PREMATURE-INFANTS; PRETERM
INFANTS; GENERAL-ANESTHESIA; SPINAL-ANESTHESIA; PEDIATRIC
ANESTHESIOLOGISTS; REGIONAL ANESTHESIA; EPIDEMIOLOGY; CHILDREN
AB Background/Purpose: The use of caudal anesthesia with sedation (CAS) has theoretical benefits over general anesthesia (GA) in high risk neonates undergoing inguinal hernia repair. This benefit has not been established in clinical studies. We compare outcomes of these two approaches at a single institution.
Methods: A retrospective review was performed of all neonates and preterm infants undergoing inguinal hernia over an 8 year period.
Results: Of 71 infants meeting inclusion criteria, 50 underwent repair with caudal block and systemic sedation, and 21 with general anesthesia. Minor incidents of respiratory depression requiring non invasive interventions were common in the first 24 h post operatively (24% for CAS, 14% with GA), 4% of patients receiving CAS had a respiratory complication which prolonged their hospital stay beyond 24 h post operation. Both required conversion to general anesthesia. Statistically significant differences between the two groups were lacking in terms of preoperative risk and post operative outcome.
Conclusions: CAS is a safe, effective anesthetic option for high risk neonates undergoing inguinal hernia repair. Patients requiring conversion to GA from CAS may be at increased risk for complications. Large, randomized trials are needed to determine any benefit over GA. Published by Elsevier Inc.
C1 [Balent, Eric; Edwards, Mary; Martin, Paul] Tripler Army Med Ctr, Dept Surg, Honolulu, HI 96859 USA.
[Lustik, Michael] Tripler Army Med Ctr, Dept Clin Invest, Honolulu, HI 96859 USA.
RP Edwards, M (reprint author), Tripler Army Med Ctr, 1 Jarrett White Rd, Honolulu, HI 96859 USA.
EM mary.j.edwards@us.army.mil
NR 19
TC 3
Z9 3
U1 0
U2 1
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0022-3468
EI 1531-5037
J9 J PEDIATR SURG
JI J. Pediatr. Surg.
PD AUG
PY 2014
VL 49
IS 8
BP 1304
EP 1307
DI 10.1016/j.jpedsurg.2013.11.005
PG 4
WC Pediatrics; Surgery
SC Pediatrics; Surgery
GA AN0EM
UT WOS:000340256200022
PM 25092095
ER
PT J
AU Jensen, PR
Simpson, D
AF Jensen, Peter R.
Simpson, Duncan
TI A Qualitative Analysis of the Experience and Impact of Killing in
Hand-to-Hand Combat
SO JOURNAL OF TRAUMATIC STRESS
LA English
DT Article
ID MENTAL-HEALTH SYMPTOMS; WAR VETERANS; IRAQ; AFGHANISTAN; PTSD;
STRESSORS; CARE
AB A growing body of research suggests that killing during military combat is closely associated with posttraumatic stress disorder (PTSD), as well as a number of other adverse mental health related conditions (e.g., dissociative experiences, violent behavior, functional impairment). This article provides first-person perspectives on the experiences and impact of killing by service members with the goal of expanding our understanding of the impact of taking a life during war. In audio-recorded phenomenological interviews, 9 service members described their experiences and the subsequent impact of killing during hand-to-hand combat. A description, supported by participant quotations, was constructed to represent the participants' experiences. Results suggest the experience and aftermath of taking a life in hand-to-hand combat was disturbing, psychologically stressful, and necessitated some form of coping after the event. Service members who killed in hand-to-hand combat viewed their actions as necessary to preserve their life and that killing in hand-to-hand combat was more emotionally taxing than killing by shooting. Our findings may help to improve providers' understanding of service members' first-person experiences of killing in hand-to-hand combat and thus provide the basis for the development of a connected and genuine relationship with such military clients.
C1 [Jensen, Peter R.] Univ Tennessee, Dept Kinesiol Recreat & Sport Studies, Knoxville, TN USA.
[Simpson, Duncan] Barry Univ, Sch Human Performance & Leisure Sci HPLS, Miami Shores, FL USA.
RP Jensen, PR (reprint author), US Mil Acad, Ctr Enhanced Performance, Jefferson Hall,1st Floor, West Point, NY 10996 USA.
EM pete.jensen1@us.army.mil
NR 25
TC 1
Z9 1
U1 0
U2 13
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0894-9867
EI 1573-6598
J9 J TRAUMA STRESS
JI J. Trauma Stress
PD AUG
PY 2014
VL 27
IS 4
BP 468
EP 473
DI 10.1002/jts.21938
PG 6
WC Psychology, Clinical; Psychiatry
SC Psychology; Psychiatry
GA AO2ZQ
UT WOS:000341198000012
PM 25158640
ER
PT J
AU Hakre, S
Arteaga, GB
Nunez, AE
Arambu, N
Aumakhan, B
Liu, M
Peel, SA
Pascale, JM
Scott, PT
AF Hakre, Shilpa
Arteaga, Griselda B.
Nunez, Aurelio E.
Arambu, Nelson
Aumakhan, Bulbulgul
Liu, Michelle
Peel, Sheila A.
Pascale, Juan M.
Scott, Paul T.
CA Panama HIV EPI Grp
TI Prevalence of HIV, Syphilis, and Other Sexually Transmitted Infections
among MSM from Three Cities in Panama
SO JOURNAL OF URBAN HEALTH-BULLETIN OF THE NEW YORK ACADEMY OF MEDICINE
LA English
DT Article
DE HIV; Syphilis; Sexually transmitted diseases; Sexual behavior;
Respondent-driven sampling; Sampling hidden populations; Panama
ID HIDDEN POPULATIONS; RESPONDENT; MEN; SEX; SURVEILLANCE; COUNTRIES; RISK
AB Respondent-driven sampling (RDS) was used to conduct a biobehavioral survey among men who have sex with men (MSM) in three cities in the Republic of Panama. We estimated the prevalence of HIV, syphilis, and other sexually transmitted infections (STIs), sociodemographic characteristics, and sexual risk behaviors. Among 603 MSM recruited, RDS-adjusted seroprevalences (95 % confidence intervals) were: HIV-David 6.6 % (2.2-11.4 %), Panama 29.4 % (19.7-39.7 %), and Colon 32.6 % (18.0-47.8 %); active syphilis-David 16.0 % (8.9-24.2 %), Panama 24.7 % (16.7-32.9 %), Colon 31.6 % (14.8-47.5 %); resolved HBV infection-David 10.0 % (4.8-16.8 %), Panama 29.4 % (20.0-38.3 %), and Colon 40.6 % (21.9-54.4 %); herpes simplex virus type 2-David 38.4 % (27.9-48.9 %), Panama 62.6 % (52.8-71.0 %), and Colon 72.9 % (57.4-85.8 %). At least a third of MSM in each city self-identified as heterosexual or bisexual. HIV prevalence is concentrated among MSM. Preventive interventions should focus on increasing HIV and syphilis testing, and increasing promotion of condom awareness and use.
C1 [Hakre, Shilpa; Liu, Michelle] Henry M Jackson Fdn Adv Mil Med, US Mil HIV Res Program, Bethesda, MD USA.
[Arteaga, Griselda B.; Pascale, Juan M.] Inst Conmemorat Gorgas Estudios Salud, Panama City, Panama.
[Arteaga, Griselda B.; Pascale, Juan M.] Univ Panama, Sch Med, Panama City, Panama.
[Nunez, Aurelio E.] Minist Hlth, Natl HIV AIDS & STI Control Program, Panama City, Panama.
[Arambu, Nelson] Del Valle Univ Guatemala, Guatemala City, Guatemala.
[Aumakhan, Bulbulgul] Minist Hlth, Natl Ctr Communicable Dis, Ulaanbaatar, Mongol Peo Rep.
[Peel, Sheila A.] Walter Reed Army Inst Res, US Mil HIV Res Program, HIV Diagnost & Reference Lab, Rockville, MD USA.
[Scott, Paul T.] Walter Reed Army Inst Res, Dept Epidemiol & Threat Assessment, US Mil HIV Res Program, Rockville, MD USA.
RP Hakre, S (reprint author), US Mil HIV Res Program, 6720-A Rockledge Dr,Suite 400, Bethesda, MD 20817 USA.
EM shakre@hivresearch.org
FU Henry M. Jackson Foundation for the Advancement of Military Medicine,
Inc. [W81XWH-07-2-0067]; U.S. Department of Defense [W81XWH-07-2-0067];
National Council for Science and Technology, Panama [COL-08-059]
FX The work was funded by a cooperative agreement (W81XWH-07-2-0067)
between the Henry M. Jackson Foundation for the Advancement of Military
Medicine, Inc., and the U.S. Department of Defense, and a grant
(COL-08-059) from the National Council for Science and Technology,
Panama.
NR 22
TC 3
Z9 3
U1 0
U2 1
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1099-3460
EI 1468-2869
J9 J URBAN HEALTH
JI J. Urban Health
PD AUG
PY 2014
VL 91
IS 4
BP 793
EP 808
DI 10.1007/s11524-014-9885-4
PG 16
WC Public, Environmental & Occupational Health; Medicine, General &
Internal
SC Public, Environmental & Occupational Health; General & Internal Medicine
GA AN6AH
UT WOS:000340674900015
PM 24927712
ER
PT J
AU Chen, D
Yen, M
Lin, P
Groff, S
Lampo, R
McInerney, M
Ryan, J
AF Chen, Dong
Yen, Max
Lin, Paul
Groff, Steve
Lampo, Richard
McInerney, Michael
Ryan, Jeffrey
TI A Corrosion Sensor for Monitoring the Early-Stage Environmental
Corrosion of A36 Carbon Steel
SO MATERIALS
LA English
DT Article
DE carbon steel; chloride; X-ray diffraction; rust; corrosion monitoring
ID CHLORIDE-INDUCED CORROSION; ALTERNATING-CURRENT; REINFORCING STEEL;
MILD-STEEL; IRON; REDUCTION; CONCRETE; RUST
AB An innovative prototype sensor containing A36 carbon steel as a capacitor was explored to monitor early-stage corrosion. The sensor detected the changes of the surface- rather than the bulk- property and morphology of A36 during corrosion. Thus it was more sensitive than the conventional electrical resistance corrosion sensors. After being soaked in an aerated 0.2 M NaCl solution, the sensor's normalized electrical resistance (R/R-0) decreased continuously from 1.0 to 0.74 with the extent of corrosion. Meanwhile, the sensor's normalized capacitance (C/C-0) increased continuously from 1.0 to 1.46. X-ray diffraction result indicates that the iron rust on A36 had crystals of lepidocrocite and magnetite.
C1 [Chen, Dong; Yen, Max; Lin, Paul; Groff, Steve] Indiana Univ Purdue Univ, Coll Engn Technol & Comp Sci, Ft Wayne, IN 46805 USA.
[Lampo, Richard; McInerney, Michael; Ryan, Jeffrey] US Army Engn Res & Dev Ctr, Construct Engn Res Lab, Champaign, IL 61826 USA.
RP Chen, D (reprint author), Indiana Univ Purdue Univ, Coll Engn Technol & Comp Sci, 2101 E Coliseum Blvd, Ft Wayne, IN 46805 USA.
EM chend@ipfw.edu; yens@ipfw.edu; lin@ipfw.edu; groff.steve@gmail.com;
Richard.G.Lampo@usace.army.mil; Michael.K.McInerney@usace.army.mil;
Jeffrey.P.Ryan@usace.army.mil
FU US Army Engineer Research and Development Centre, Construction
Engineering Research Laboratory [W9132T-10-2-0056]
FX The research project was funded by the US Army Engineer Research and
Development Centre, Construction Engineering Research Laboratory through
the contract of W9132T-10-2-0056. The authors also thank Robert Tilbury
and Mengwei Li for their help for this project. XRD was performed in the
Argast Family Instrumentation and Analysis Lab at the Indiana
University-Purdue University Fort Wayne.
NR 36
TC 4
Z9 4
U1 1
U2 14
PU MDPI AG
PI BASEL
PA POSTFACH, CH-4005 BASEL, SWITZERLAND
SN 1996-1944
J9 MATERIALS
JI Materials
PD AUG
PY 2014
VL 7
IS 8
BP 5746
EP 5760
DI 10.3390/ma7085746
PG 15
WC Materials Science, Multidisciplinary
SC Materials Science
GA AO3EC
UT WOS:000341210400023
ER
PT J
AU Rasmussen, TE
Reilly, PA
Baer, DG
AF Rasmussen, Todd E.
Reilly, Patricia A.
Baer, David G.
TI Why Military Medical Research?
SO MILITARY MEDICINE
LA English
DT Editorial Material
ID TRAUMA SYSTEM; LESSONS; EVENTS
C1 [Rasmussen, Todd E.] US Combat Casualty Care Res Program, Ft Detrick, MD 21702 USA.
[Reilly, Patricia A.] US Army Med Res & Mat Command, Ft Detrick, MD 21702 USA.
[Baer, David G.] US Army Inst Surg Res, Ft Sam Houston, TX 78234 USA.
RP Rasmussen, TE (reprint author), US Combat Casualty Care Res Program, 722 Doughten St,Room 3, Ft Detrick, MD 21702 USA.
NR 9
TC 6
Z9 6
U1 0
U2 0
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
EI 1930-613X
J9 MIL MED
JI Milit. Med.
PD AUG
PY 2014
VL 179
IS 8
SU S
SI SI
BP 1
EP 2
DI 10.7205/MILMED-D-14-00245
PG 2
WC Medicine, General & Internal
SC General & Internal Medicine
GA AN7UP
UT WOS:000340806800002
PM 25102540
ER
PT J
AU Hack, DC
AF Hack, Dallas C.
TI MEETING WARFIGHTER MEDICAL CHALLENGES Proceedings of the 2012 Military
Health System Research Symposium Foreword
SO MILITARY MEDICINE
LA English
DT Editorial Material
C1 [Hack, Dallas C.] Combat Casualty Care Res Program, Ft Detrick, MD USA.
[Hack, Dallas C.] US Army Med Res & Mat Command, Ft Detrick, MD USA.
RP Hack, DC (reprint author), US Army Med Res & Mat Command, 504 Scott St,Bldg 810, Ft Detrick, MD 21702 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
EI 1930-613X
J9 MIL MED
JI Milit. Med.
PD AUG
PY 2014
VL 179
IS 8
SU S
SI SI
BP II
EP II
DI 10.7205/MILMED-D-14-00243
PG 1
WC Medicine, General & Internal
SC General & Internal Medicine
GA AN7UP
UT WOS:000340806800001
PM 25102553
ER
PT J
AU Reilly, PA
AF Reilly, Patricia A.
TI The Military Health System Research Symposium: A Short Retrospective
SO MILITARY MEDICINE
LA English
DT Editorial Material
C1 US Army Med Res & Mat Command, Ft Detrick, MD 21702 USA.
RP Reilly, PA (reprint author), US Army Med Res & Mat Command, 504 Scott St,Bldg 810, Ft Detrick, MD 21702 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
EI 1930-613X
J9 MIL MED
JI Milit. Med.
PD AUG
PY 2014
VL 179
IS 8
SU S
SI SI
BP 3
EP 3
DI 10.7205/MILMED-D-14-00242
PG 1
WC Medicine, General & Internal
SC General & Internal Medicine
GA AN7UP
UT WOS:000340806800003
PM 25102541
ER
PT J
AU Wang, HCH
Choi, JH
Greene, WA
Plamper, ML
Cortez, HE
Chavko, M
Li, YS
Lucca, JJD
Johnson, AJ
AF Wang, Heuy-Ching Hetty
Choi, Jae-Hyek
Greene, Whitney A.
Plamper, Mark L.
Cortez, Hector E.
Chavko, Mikulas
Li, Yansong
Lucca, Jurandir J. Dalle
Johnson, Anthony J.
TI Pathophysiology of Blast-Induced Ocular Trauma With Apoptosis in the
Retina and Optic Nerve
SO MILITARY MEDICINE
LA English
DT Article
ID OPERATION-IRAQI-FREEDOM; INJURIES
AB Background: Blast-induced ocular trauma is a frequent cause of morbidity for survivors of improvised explosive devices. Blast overpressure (BOP) of 120 +/- 7 KPa has been shown to cause damage to lungs, brain, and gut in a rat model; however, the effects of BOP on ocular tissues have not been characterized. To elucidate the pathophysiology of blast-induced ocular trauma, ocular tissues from rats subjected to blast were examined for evidence of apoptosis by the detection of activated caspase 3 and TUNEL assay in their ocular tissues. Methods: A compressed air shock tube was used to deliver 120 7 KPa of BOP for duration of 2 msec to the right side of the rats.-Rats were then euthanized at specific time points after blast exposure (3 hours, 24 hours, 48 hours). Ocular tissues were processed for immunohistochemistry to detect activated caspase 3 and TUNEL assay. Tissues were evaluated for relative levels of positive signal as compared to nonblast exposed controls. Results: Activated caspase 3 was detected in the optic nerve, ganglion layer, and inner nuclear layer post blast exposure. At 24 and 48 hours, the inner nuclear layer from the right side had more cells with activated caspase 3. In the optic nerve, the highest levels of activated caspase 3 were detected on the right side at 24 hours post blast. Conclusion: BOP of 120 7 KPa induces optic neuropathy and retinal damage. In both the optic nerve and retina, caspase 3 was activated in the right and left sides following blast exposure. The results of this study reveal that blast exposure induces apoptosis in both the optic nerve and retinal tissues.
C1 [Wang, Heuy-Ching Hetty; Choi, Jae-Hyek; Greene, Whitney A.; Plamper, Mark L.; Cortez, Hector E.; Johnson, Anthony J.] US Army Inst Surg Res, Ocular Trauma Task Area, Jbsa Fort Sam Houston, TX 78234 USA.
[Chavko, Mikulas] US Naval Med Res Ctr, NeuroTrauma Dept, Silver Spring, MD 20910 USA.
[Li, Yansong; Lucca, Jurandir J. Dalle] US Army Inst Surg Res, Immunomodulat Trauma Program, Jbsa Fort Sam Houston, TX 78234 USA.
RP Wang, HCH (reprint author), US Army Inst Surg Res, Ocular Trauma Task Area, 3698 Chambers Pass,Bldg 3611, Jbsa Fort Sam Houston, TX 78234 USA.
FU National Research Council; U.S. Army Military Operational Medicine
Research Program; Clinical and Rehabilitative Medicine Research Program;
Defense Medical Research and Development Program
FX H-CW participated in study design, sample acquisition, contributed to
data interpretation, and provided experimental supplies, equipment, and
critical input into the article. J-HC participated in sample
acquisition, processing, and analysis of data. WAG contributed to data
interpretation, data acquisition, and drafted the article. MLP and HEC
participated in sample acquisition, processing, and data acquisition. MC
participated in study design and sample acquisition. YL participated in
sample acquisition. JJDL participated in study design and sample
acquisition. AJJ provided critical input into the article. All authors
read and approved the final article. The authors J-HC and WAG are
supported by the National Research Council Postdoctoral Fellowship. This
work was supported by U.S. Army Military Operational Medicine Research
Program, Clinical and Rehabilitative Medicine Research Program, and
Defense Medical Research and Development Program.
NR 14
TC 4
Z9 5
U1 3
U2 7
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
EI 1930-613X
J9 MIL MED
JI Milit. Med.
PD AUG
PY 2014
VL 179
IS 8
SU S
SI SI
BP 34
EP 40
DI 10.7205/MILMED-D-13-00504
PG 7
WC Medicine, General & Internal
SC General & Internal Medicine
GA AN7UP
UT WOS:000340806800009
PM 25102547
ER
PT J
AU McGhee, LL
Maani, CV
Garza, TH
Slater, TM
Petz, LN
Fowler, M
AF McGhee, Laura L.
Maani, Christopher V.
Garza, Thomas H.
Slater, Terry M.
Petz, Lawrence N.
Fowler, Marcie
TI The Intraoperative Administration of Ketamine to Burned US Service
Members Does Not Increase the Incidence of Post-Traumatic Stress
Disorder
SO MILITARY MEDICINE
LA English
DT Article
ID PAIN MANAGEMENT; INJURY PAIN; ANALGESIA; MORPHINE; IRAQ; AFGHANISTAN;
ANESTHESIA; TRAUMA; CARE; PREVALENCE
AB Aim: Patients with severe burns typically undergo multiple surgeries, and ketamine is often used as part of the multimodal anesthetic regimen during such surgeries. The anesthetic ketamine is an N-methyl-D-aspartate receptor antagonist that also provides analgesia at subanesthetic doses, but the psychoactive side effects of ketamine have caused concern about its potential psychological effects on a combat-wounded population. Post-traumatic stress disorder (PTSD) affects approximately 30% of burned U.S. service members injured in Operation Iraqi Freedom/Operation Enduring Freedom. A preliminary analysis by our research group reported that patients who received perioperative ketamine had a significantly lower prevalence of PTSD than those injured service members who did not receive ketamine. We have now expanded this research to examine the relationship between ketamine and PTSD development in a much larger population. Methods: A retrospective analysis on data from service members being treated for burns at the San Antonio Military Medical Center was conducted. Collected data included drugs received, injury severity score (ISS), total body surface area (TBSA) burned, length of hospital stay (LOS), number of intensive care unit days, number of surgeries, and PTSD Checklist-Military (PCL-M) scores and administration dates. Subjects were grouped based on intraoperative receipt of ketamine, and the groups were compared. The groups were binary for ketamine (yes or no), and dose of ketamine administered was not included in data analyses. Propensity score matching based on ISS and TBSA was performed to control for individual differences in burn severity. Results: Two hundred eighty-nine burned U.S. service members received the PCL-M at least 30 days after injury. Of these subjects, 189 received intraoperative ketamine, and 100 did not. Despite significantly greater injuries, as evidenced by significantly higher TBSA burned and ISS (p < 0.01), patients who received ketamine did not screen positive for PTSD at a different rate than those patients who did not (24% vs. 26.98%, p = 0.582). Patients receiving intraoperative ketamine also underwent a significantly greater number of surgeries, spent more time in the hospital, spent more days in the ICU, and received more morphine equivalent units (p < 0.0001). Propensity score matching based on ISS and TBSA resulted in a total subject number of 130. In the matched samples, subjects who received ketamine still underwent significantly more surgeries and experienced longer hospital stays (p < 0.0001). Again, there was no statistically significant difference in the incidence of a positive screen for PTSD based upon the receipt of ketamine (28% vs. 26.15%, p = 0.843). Conclusions: Ketamine is often used in burn patients to reduce opioid usage and decrease the hemodynamic and respiratory side effects. Although this study does not show a benefit of ketamine on PTSD development that was identified in previous work with a smaller sample number, it does support the conclusion that ketamine does not increase PTSD development in burned service members.
C1 [McGhee, Laura L.; Garza, Thomas H.; Slater, Terry M.; Petz, Lawrence N.; Fowler, Marcie] US Army Inst Surg Res, Ft Sam Houston, TX 78239 USA.
[Maani, Christopher V.] Brooke Army Med Ctr, Dept Anesthesia & Operat Serv, Ft Sam Houston, TX 78234 USA.
RP McGhee, LL (reprint author), US Army Inst Surg Res, 3698 Chambers Pass,Bldg 3611, Ft Sam Houston, TX 78239 USA.
FU U.S. Army Institute of Surgical Research Battlefield Pain Control Task
Area; U.S. Army Medical Research and Materiel Command Combat Casualty
Program; Clinical and Rehabilitative Medicine Research Program
FX The authors acknowledge Mr. John Jones, USAISR statistician, for
assistance in statistical analyses and data interpretation. This study
was funded by the U.S. Army Institute of Surgical Research Battlefield
Pain Control Task Area and the U.S. Army Medical Research and Materiel
Command Combat Casualty and Clinical and Rehabilitative Medicine
Research Programs.
NR 41
TC 4
Z9 5
U1 1
U2 6
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
EI 1930-613X
J9 MIL MED
JI Milit. Med.
PD AUG
PY 2014
VL 179
IS 8
SU S
SI SI
BP 41
EP 46
DI 10.7205/MILMED-D-13-00481
PG 6
WC Medicine, General & Internal
SC General & Internal Medicine
GA AN7UP
UT WOS:000340806800010
PM 25102548
ER
PT J
AU Langworthy, MJ
Nelson, F
Owens, BD
AF Langworthy, Michael J.
Nelson, Fred
Owens, Brett D.
TI Viscosupplementation for Treating Osteoarthritis in the Military
Population
SO MILITARY MEDICINE
LA English
DT Review
ID NONSTEROIDAL ANTIINFLAMMATORY DRUGS; RANDOMIZED CONTROLLED-TRIAL;
ANTERIOR CRUCIATE LIGAMENT; KNEE OSTEOARTHRITIS; HYALURONIC-ACID; HYLAN
G-F-20; INTRAARTICULAR HYALURONAN; CARTILAGE DEGRADATION; OARSI
RECOMMENDATIONS; METABOLIC SYNDROME
AB Military personnel have a greater risk of developing osteoarthritis (OA) than the general population. OA is a chronic, painful, and debilitating disease with a high cost burden. Compared with the general population, a higher prevalence of post-traumatic OA has been reported in the military. Using recent literature, we aim to improve the understanding of post-traumatic OA, with an exploration of the pathophysiology of OA. Our review encompasses the current treatment modalities for alleviating the pain from OA with a focus on viscosupplementation. A multimodal approach may be beneficial for the relief of OA pain and improvement of function in military personnel with early OA, and may lower the cost burden.
C1 [Langworthy, Michael J.] Southcoast Hlth Syst, New Bedford, MA 02740 USA.
[Nelson, Fred] Henry Ford Hosp, Dept Orthopaed, San Clemente, CA 92672 USA.
[Owens, Brett D.] Keller Army Hosp, USUHS, West Point, NY 10996 USA.
RP Langworthy, MJ (reprint author), Southcoast Hlth Syst, 101 Page St, New Bedford, MA 02740 USA.
FU Sanofi Biosurgery
FX Medical writing support was provided by Susan Bijur, PhD of Precise
Publications, LLC, which was funded by Sanofi Biosurgery.
NR 54
TC 0
Z9 0
U1 0
U2 6
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
EI 1930-613X
J9 MIL MED
JI Milit. Med.
PD AUG
PY 2014
VL 179
IS 8
BP 815
EP 820
DI 10.7205/MILMED-D-14-00052
PG 6
WC Medicine, General & Internal
SC General & Internal Medicine
GA AN7UO
UT WOS:000340806700002
PM 25102523
ER
PT J
AU Dabbs, C
Watkins, EY
Fink, DS
Eick-Cost, A
Milliken, AM
AF Dabbs, Clifton
Watkins, Eren Youmans
Fink, David S.
Eick-Cost, Angelia
Milliken, Amy M.
TI Opiate-Related Dependence/Abuse and PTSD Exposure Among the
Active-Component US Military, 2001 to 2008
SO MILITARY MEDICINE
LA English
DT Article
ID POSTTRAUMATIC-STRESS-DISORDER; PERSIAN-GULF-WAR; SUBSTANCE USE
DISORDERS; MENTAL-HEALTH PROBLEMS; DRUG DISORDERS; VETERANS; IRAQ;
AFGHANISTAN; ILLNESS; ABUSE
AB Background: Over the past 5 years, diagnoses for opiate abuse or dependency and post-traumatic stress disorder (PTSD) have increased across all U.S. military services. Moreover, in the United States, opiate prescription dependence and abuse has now surpassed all other illicit drugs of abuse with the exception of marijuana. Some research indicates that PTSD is predictive of substance dependence and abuse, while other research suggests that substance dependence and abuse may lead to events that trigger PTSD. This dichotomy has not been extensively explored within a military population. Methods: Using conditional multiple logistic regression analysis, a matched case control study with 18,606 active-component U.S. military service members was conducted to examine the relationship between opiate dependence or abuse and PTSD. Results: Among the 18,606 service members included in the analysis, 21% were cases and 79% were controls. Thirteen percent of service members with substance dependence or abuse diagnosis had a prior PTSD diagnosis compared to 1% of controls. After, adjusting for sociodemographic and military characteristics, the odds of having a prior diagnosis of PTSD was 28 (95% CI: 21.24-37.78) times greater for service members with opiate abuse/dependency compared to controls. Conclusion: These findings suggest active duty military personnel diagnosed with PTSD should be closely monitored to reduce the likelihood of future morbidity because of opiate dependence or abuse.
C1 [Dabbs, Clifton] Walter Reed Army Inst Res, Dept Prevent Med, Bel Air, MD 21015 USA.
[Watkins, Eren Youmans; Fink, David S.; Milliken, Amy M.] Army Inst Publ Hlth, Behav & Social Hlth Outcomes Program, Aberdeen Proving Ground, MD 21010 USA.
[Eick-Cost, Angelia] Armed Forces Hlth Surveillance Ctr, Silver Spring, MD 21090 USA.
RP Dabbs, C (reprint author), Walter Reed Army Inst Res, Dept Prevent Med, 621 Derringer, Bel Air, MD 21015 USA.
NR 42
TC 2
Z9 2
U1 3
U2 13
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
EI 1930-613X
J9 MIL MED
JI Milit. Med.
PD AUG
PY 2014
VL 179
IS 8
BP 885
EP 890
DI 10.7205/MILMED-D-14-00012
PG 6
WC Medicine, General & Internal
SC General & Internal Medicine
GA AN7UO
UT WOS:000340806700010
PM 25102531
ER
PT J
AU Walker, MR
Kallingal, GJS
Musser, JE
Folen, R
Stetz, MC
Clark, JY
AF Walker, Marc R.
Kallingal, George J. S.
Musser, John E.
Folen, Raymond
Stetz, Melba C.
Clark, Joseph Y.
TI Treatment Efficacy of Virtual Reality Distraction in the Reduction of
Pain and Anxiety During Cystoscopy
SO MILITARY MEDICINE
LA English
DT Article
ID FLEXIBLE CYSTOSCOPY
AB Objective: Assessment of virtual reality (VR) distraction for alleviating pain and anxiety during flexible cystoscopy. Cystoscopy is a common ambulatory procedure performed in Urology and can be associated with moderate pain and anxiety. Sophisticated distraction techniques are not used with cystoscopy and VR has not been studied for this procedure. We designed a prospective, randomized, controlled trial assessing the efficacy of VR for alleviating pain and anxiety during flexible cystoscopy. Methods: Adult men referred for cystoscopy were randomized into a control or VR group. Subjects were given preprocedure and postprocedure questionnaires addressing anxiety, pain, and time spent thinking about pain. Vitals signs and galvanic skin monitors were used as objective measures. The control group underwent routine cystoscopy and the VR group underwent cystoscopy with VR. Physicians answered a postprocedure questionnaire assessing the difficulty of the exam. All questionnaires used a visual analog score for assessment. Results: 23 patients enrolled in the control group and 22 in the VR group. Mean scores and Student's t-test were employed to analyze the data. No data endpoints showed a statistically significant difference between the 2 groups. Conclusions: We concluded no benefit to VR distraction mitigating pain in male patients during cystoscopy.
C1 [Walker, Marc R.; Kallingal, George J. S.; Musser, John E.; Folen, Raymond; Stetz, Melba C.; Clark, Joseph Y.] Tripler Army Med Ctr, Honolulu, HI 96850 USA.
RP Walker, MR (reprint author), Tripler Army Med Ctr, 1 Jarrett White Rd, Honolulu, HI 96850 USA.
NR 14
TC 2
Z9 2
U1 1
U2 6
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
EI 1930-613X
J9 MIL MED
JI Milit. Med.
PD AUG
PY 2014
VL 179
IS 8
BP 891
EP 896
DI 10.7205/MlLMED-D-13-00343
PG 6
WC Medicine, General & Internal
SC General & Internal Medicine
GA AN7UO
UT WOS:000340806700011
PM 25102532
ER
PT J
AU Piche, BM
Stankorb, SM
Salgueiro, M
AF Piche, Brittney M.
Stankorb, Susan M.
Salgueiro, Marybeth
TI Attitudes, Beliefs, and Behaviors of Active Duty Soldiers Attending the
ArmyMOVE! Weight Management Program
SO MILITARY MEDICINE
LA English
DT Article
ID SELF-PERCEPTION; US ARMY; OVERWEIGHT; OBESITY; CONSUMPTION; PREVALENCE;
EXERCISE; FITNESS; WOMEN
AB Introduction: The objective of this study was to assess the attitudes, beliefs, and behaviors of Active Duty Soldiers attending the ArmyMOVE! (AM!) weight management program at three locations in Texas. Methods: A 40-question survey on weight-loss attitudes, beliefs, and behaviors was administered to participants before receiving the AM! education. Results: The response rate was 82.8% (n = 312). The sample was predominantly obese (64.3%), male (81.7%), and enlisted (95.3%). Only 30% were able to correctly identify their weight status using body mass index. The majority felt that weight standards were achievable (47%) and were confident in their ability to make diet (88.8%) and exercise (87.5%) changes; though most felt the tape test was not an accurate measure of body composition (71.5%). Soldiers reported using suboptimal weight-loss behaviors including diet pills (48.7%), sweat suits/saunas (44.9%), fasting (45.3%), and herbal supplements (31.1%), whereas the majority were not achieving proven recommendations for weight loss including adequate fruit (57%) and vegetable (93%) intake and adequate sleep duration (80%). Conclusion: This survey demonstrated AM! participants are using suboptimal methods of weight loss, few are following the Army Surgeon General's guidelines for nutrition and sleep, and an increased intensity of the AM! program is desired by the participants.
C1 [Piche, Brittney M.; Stankorb, Susan M.; Salgueiro, Marybeth] Brooke Army Med Ctr, Dept Med Nutr, Ft Sam Houston, TX 78234 USA.
RP Piche, BM (reprint author), Brooke Army Med Ctr, Dept Med Nutr, 3551 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA.
NR 37
TC 1
Z9 1
U1 1
U2 2
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
EI 1930-613X
J9 MIL MED
JI Milit. Med.
PD AUG
PY 2014
VL 179
IS 8
BP 906
EP 912
DI 10.7205/MILMED-D-13-00498
PG 7
WC Medicine, General & Internal
SC General & Internal Medicine
GA AN7UO
UT WOS:000340806700014
PM 25102535
ER
PT J
AU Boyle, EW
AF Boyle, Eric W.
TI World War I Medical Films and Photography
SO MILITARY MEDICINE
LA English
DT Editorial Material
C1 US Army Med Res & Mat Command, Natl Museum Hlth & Med, Silver Spring, MD 20910 USA.
RP Boyle, EW (reprint author), US Army Med Res & Mat Command, Natl Museum Hlth & Med, 2500 Linden Lane, Silver Spring, MD 20910 USA.
NR 3
TC 0
Z9 0
U1 0
U2 3
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
EI 1930-613X
J9 MIL MED
JI Milit. Med.
PD AUG
PY 2014
VL 179
IS 8
BP 933
EP 934
DI 10.7205/MILMED-D-14-00186
PG 2
WC Medicine, General & Internal
SC General & Internal Medicine
GA AN7UO
UT WOS:000340806700018
PM 25102539
ER
PT J
AU Wu, ZZ
Han, XG
Zheng, JX
Wei, Y
Qiao, RM
Shen, F
Dai, JQ
Hu, LB
Xu, K
Lin, Y
Yang, WL
Pan, F
AF Wu, Zhongzhen
Han, Xiaogang
Zheng, Jiaxin
Wei, Yi
Qiao, Ruimin
Shen, Fei
Dai, Jiaqi
Hu, Liangbing
Xu, Kang
Lin, Yuan
Yang, Wanli
Pan, Feng
TI Depolarized and Fully Active Cathode Based on Li(Ni0.5Co0.2Mn0.3)O-2
Embedded in Carbon Nanotube Network for Advanced Batteries
SO NANO LETTERS
LA English
DT Article
DE Depolarization; fill-active cathode; low functionalized CNT; NCM523;
capacity; delithiation kinetic
ID LITHIUM-ION BATTERIES; ELECTRODES; LINI1/3CO1/3MN1/3O2; PERFORMANCE;
CHEMISTRY; GRAPHITE
AB Improving battery capacity and power is a daunting challenge, and in Li-ion batteries positive electrodes often set the limitation on both properties. Layered transition-metal oxides have. served as the mainstream cathode materials for high-energy batteries due to their large theoretical capacity (similar to 280 mAh/g). Here we report a significant enhancement of cathode capacity utilization through a novel concept of material design. By embedding Li(Ni0.5Co0.2Mn0.3)O-2 in the single wall carbon nanotube (CNT) network, we created a composite in which all components are electrochemically active. Long-term charge/discharge stability was obtained between 3.0 and 4.8 V, and both Li(Ni0.5Co0.2Mn0.3)O-2 and CNT contribute to the overall reversible capacity by 250 and 50 mAh/g, respectively. The observed improvement causes significant depolarization within the electrodes through the CNT network system. Additionally, the depolarization provides the ideal template to understand the solid reaction mechanism of Li(Ni0.5Co0.2Mn0.3)O-2 by demonstrating well-defined two-stage delithiation kinetics consistent with first-principle calculations, which would be otherwise impossible. These results deliver new insights on both practical designs and fundamental understandings of battery cathodes.
C1 [Wu, Zhongzhen; Zheng, Jiaxin; Wei, Yi; Lin, Yuan; Pan, Feng] Peking Univ, Shenzhen Grad Sch, Sch Adv Mat, Shenzhen 518055, Peoples R China.
[Han, Xiaogang; Shen, Fei; Dai, Jiaqi; Hu, Liangbing] Univ Maryland, Dept Mat Sci & Engn, College Pk, MD 20742 USA.
[Qiao, Ruimin; Yang, Wanli] Univ Calif Berkeley, Lawrence Berkeley Natl Lab, Adv Light Source, Berkeley, CA 94720 USA.
[Xu, Kang] US Army Res Lab, Adelphi, MD 20783 USA.
RP Pan, F (reprint author), Peking Univ, Shenzhen Grad Sch, Sch Adv Mat, Shenzhen 518055, Peoples R China.
EM panfeng@pkusz.edu.cn
RI Yang, Wanli/D-7183-2011; Qiao, Ruimin/E-9023-2013; Hu,
Liangbing/N-6660-2013; Han, Xiaogang/D-6430-2015; lin, yuan/G-9390-2013
OI Yang, Wanli/0000-0003-0666-8063; Han, Xiaogang/0000-0002-4785-6506; lin,
yuan/0000-0003-3410-3588
FU Shenzhen Science and Technology Research [ZDSY20130331145131323,
SGLH20120928095706623, CXZZ20120829172325895, JCYJ20120614150338154];
ShenZhen National SuperComputing Center
FX This work was financially supported jointly by Shenzhen Science and
Technology Research Grant (No. ZDSY20130331145131323,
SGLH20120928095706623, CXZZ20120829172325895, and
JCYJ20120614150338154). Additionally, we acknowledge the support of
ShenZhen National SuperComputing Center and Daikin America who provided
gratis the baseline high voltage electrolyte (without HFiP).
NR 33
TC 33
Z9 33
U1 15
U2 143
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 1530-6984
EI 1530-6992
J9 NANO LETT
JI Nano Lett.
PD AUG
PY 2014
VL 14
IS 8
BP 4700
EP 4706
DI 10.1021/nl5018139
PG 7
WC Chemistry, Multidisciplinary; Chemistry, Physical; Nanoscience &
Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied;
Physics, Condensed Matter
SC Chemistry; Science & Technology - Other Topics; Materials Science;
Physics
GA AN2WH
UT WOS:000340446200078
PM 24979204
ER
PT J
AU Lazarus, N
Meyer, CD
Bedair, SS
Nochetto, H
Kierzewski, IM
AF Lazarus, N.
Meyer, C. D.
Bedair, S. S.
Nochetto, H.
Kierzewski, I. M.
TI Multilayer liquid metal stretchable inductors
SO SMART MATERIALS AND STRUCTURES
LA English
DT Article
DE inductors; stretchable electronics; liquid metal; galinstan; fluidics
ID SPIRAL INDUCTORS; ELECTRONICS; CONDUCTORS; GOLD
AB Liquid metals are ideally suited for creating low resistance traces able to undergo large mechanical strains. In this work, multilayer fluidic channels in soft silicone are used to create two inductor topologies, a solenoid and a double planar coil, based on the liquid metal galinstan. Electromechanical models were developed for the inductance upon stretching for each inductor, finding that the double planar coil has lower strain sensitivity in each direction than the solenoid. A three turn double planar coil and six turn solenoid, with unstretched inductances of approximately 250 nH and 55 nH respectively, were fabricated and tested using custom tensile and compressive strain testing setups and compared with the analytical model. The double planar coil was found to increase in inductance when stretched in either in-plane axes, with a measured rise of approximately 40% for 100% strain. The solenoid decreased in inductance by 24% for 100% strain along the core direction, and increased by 50% for the same strain along the core width.
C1 [Lazarus, N.] US Army Res Lab, Oak Ridge Assoc Univ Fellowship Program, Adelphi, MD 20783 USA.
[Meyer, C. D.; Bedair, S. S.] US Army Res Lab, Sensors & Elect Devices Directorate, Adelphi, MD 20783 USA.
[Nochetto, H.; Kierzewski, I. M.] Gen Tech Serv LLC, Trenton, NJ 07719 USA.
RP Lazarus, N (reprint author), US Army Res Lab, Oak Ridge Assoc Univ Fellowship Program, 2800 Powder Mill Rd, Adelphi, MD 20783 USA.
EM nathan.lazarus2.ctr@mail.mil
FU Army Research Laboratory
FX This work was sponsored by the Army Research Laboratory and was
accomplished under Cooperative Agreement Number W911NF-12-2-0019. The
views and conclusions contained in this document are those of the
authors and should not be interpreted as representing the official
policies, either expressed or implied, of the Army Research Laboratory
or the US Government. The US Government is authorized to reproduce and
distribute reprints for Government purposes notwithstanding any
copyright notation herein.
NR 27
TC 10
Z9 10
U1 4
U2 15
PU IOP PUBLISHING LTD
PI BRISTOL
PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND
SN 0964-1726
EI 1361-665X
J9 SMART MATER STRUCT
JI Smart Mater. Struct.
PD AUG
PY 2014
VL 23
IS 8
AR 085036
DI 10.1088/0964-1726/23/8/085036
PG 10
WC Instruments & Instrumentation; Materials Science, Multidisciplinary
SC Instruments & Instrumentation; Materials Science
GA AO0SH
UT WOS:000341021600036
ER
PT J
AU Pruitt, BA
AF Pruitt, Basil A., Jr.
TI Reflection Evolution of the Field over Seven Decades
SO SURGICAL CLINICS OF NORTH AMERICA
LA English
DT Article
DE Burns; Fluid resuscitation; Inhalation injury; Burn wound care;
Metabolic response to injury; Organization of burn care and research
ID INHALATION INJURY; THERMAL-INJURY; BURN PATIENTS; SMOKE-INHALATION;
GROWTH-HORMONE; CHILDREN; CATECHOLAMINES; RESUSCITATION; MORTALITY;
PROGRESS
AB Marked expansion of physiologic understanding and the improvement of burn patient outcomes have resulted from multidisciplinary clinical/laboratory research programs at burn centers in the United States and elsewhere.
C1 [Pruitt, Basil A., Jr.] US Army, Inst Surg Res, Ft Sam Houston, TX 78234 USA.
RP Pruitt, BA (reprint author), Univ Texas Hlth Sci Ctr San Antonio, Dept Surg, 7703 Floyd Curl Dr, San Antonio, TX 78229 USA.
EM pruitt@uthscsa.edu
NR 53
TC 1
Z9 1
U1 0
U2 4
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0039-6109
EI 1558-3171
J9 SURG CLIN N AM
JI Surg. Clin.-North Am.
PD AUG
PY 2014
VL 94
IS 4
BP 721
EP +
DI 10.1016/j.suc.2014.05.001
PG 21
WC Surgery
SC Surgery
GA AO2CN
UT WOS:000341123200003
PM 25085084
ER
PT J
AU Cancio, LC
AF Cancio, Leopoldo C.
TI Initial Assessment and Fluid Resuscitation of Burn Patients
SO SURGICAL CLINICS OF NORTH AMERICA
LA English
DT Article
DE Burns; Inhalation injury; Resuscitation
ID SMOKE-INHALATION INJURY; THERMAL-INJURY; MILITARY CASUALTIES; OUTCOMES
AB For the physician or surgeon practicing outside the confines of a burn center, initial assessment and fluid resuscitation will encompass most of his or her exposure to patients with severe burns. The importance of this phase of care should not be underestimated. This article provides a review of how to perform initial resuscitation of patients with significant burns and/or inhalation injury, while arranging for transfer to a regional burn center.
C1 US Army, Inst Surg Res, JBSA, Med Corps, Ft Sam Houston, TX 78234 USA.
RP Cancio, LC (reprint author), US Army, Inst Surg Res, JBSA, Med Corps, 3698 Chambers Pass, Ft Sam Houston, TX 78234 USA.
EM divego99@gmail.com
FU Percussionaire, Inc.
FX The author is a coinventor of Burn Resuscitation Decision Support
Software (Burn Navigator), which has been licensed by the US Army to
Arcos, Inc. for commercial production. The author has assigned his
rights to the US Army, but would receive a small percentage of any
royalties. He has received payment for travel expenses from
Percussionaire, Inc.
NR 36
TC 5
Z9 5
U1 0
U2 5
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0039-6109
EI 1558-3171
J9 SURG CLIN N AM
JI Surg. Clin.-North Am.
PD AUG
PY 2014
VL 94
IS 4
BP 741
EP +
DI 10.1016/j.suc.2014.05.003
PG 15
WC Surgery
SC Surgery
GA AO2CN
UT WOS:000341123200004
PM 25085085
ER
PT J
AU Ivashchenko, VI
Veprek, S
Turchi, PEA
Shevchenko, VI
Leszczynski, J
Gorb, L
Hill, F
AF Ivashchenko, V. I.
Veprek, S.
Turchi, P. E. A.
Shevchenko, V. I.
Leszczynski, J.
Gorb, L.
Hill, F.
TI First-principles molecular dynamics investigation of thermal and
mechanical stability of the TiN(001)/AlN and ZrN(001)/AIN
heterostructures
SO THIN SOLID FILMS
LA English
DT Article
DE Superhard TiN- and ZrN-based heterostructures; Nanocomposites;
First-principles molecular dynamics; Dynamic stability; Ideal strength;
Stress-strain relationships
ID AB-INITIO; COATINGS; DECOMPOSITION; PSEUDOPOTENTIALS; TI1-XALXN; SYSTEM;
ALN
AB First-principles quantum molecular dynamics investigations of TiN(001)/AlN and ZrN(001)/AIN heterostructures with one and two monolayers (1 ML and 2 ML) of AIN interfacial layers were carried out in the temperature range of 0-1400 K with subsequent static relaxation. It is shown that the epitaxially stabilized cubic B1-AIN interfacial layers are preserved in all TiN(001)/AIN heterostructures over the whole temperature range. In the ZrN(001)/AlN heterostructures, the B1-AIN(001) interfacial layer exists at 0 K, but it transforms into a distorted one at 10 K consisting of tetrahedral AlN4, octahedral AIN6, and AIN5 units. The thermal stability of the interfaces was investigated by studying the phonon dynamic stability of the B1-AlN phase with different lattice parameters. The calculations showed that the B1-AIN interface should be unstable in ZrN(001)/AIN heterostructures and nanocomposites, and in those based on transition metal nitrides with lattice parameters larger than 4.4 A. Electronic band structure calculations showed that energy gap forms around the Fermi energy for all interfaces. The formation of the interfacial AIN layer in TiN and ZrN crystals reduces their ideal tensile and shear strengths. Upon tensile load, decohesion occurs between Ti (Zr) and N atoms adjacent to the 1 MLAIN interfacial layer, whereas in the case of 2 ML AIN it occurs inside the TiN and ZrN slabs. The experimentally reported strength enhancement in the TiN/AIN and ZrN/AlN heterostructures is attributed to impeding effect of the interfacial layer on the plastic flow. (C) 2014 Elsevier B.V. All rights reserved.
C1 [Ivashchenko, V. I.; Shevchenko, V. I.] Natl Acad Sci Ukraine, Inst Problems Mat Sci, UA-03142 Kiev, Ukraine.
[Veprek, S.] Tech Univ Munich, Dept Chem, D-85747 Garching, Germany.
[Turchi, P. E. A.] Lawrence Livermore Natl Lab L 352, Livermore, CA 94551 USA.
[Leszczynski, J.; Gorb, L.] Jackson State Univ, Interdisciplinary Ctr Nanotox, Dept Chem & Biochem, Jackson, MS 39217 USA.
[Gorb, L.; Hill, F.] US Army ERDC, Vicksburg, MS 39180 USA.
RP Ivashchenko, VI (reprint author), Natl Acad Sci Ukraine, Inst Problems Mat Sci, Krzhyzhanosky Str 3, UA-03142 Kiev, Ukraine.
EM ivash@ipms.kiev.ua; stan.veprek@lrz.tum.de
RI Veprek, Stan/C-1248-2008
OI Veprek, Stan/0000-0002-6016-3093
FU STCU [5539]; U.S. Department of Energy; Lawrence Livermore National
Laboratory [DE-AC52-07NA27344]
FX This work was supported by the STCU contract no. 5539. The work of P.T.
was performed under the auspices of the U.S. Department of Energy by the
Lawrence Livermore National Laboratory under contract no.
DE-AC52-07NA27344. The authors are grateful to the directorate of the
Summery Institute at Jackson State University for financial support and
the possibility to perform large-scale calculations. S.V. thanks SHM
Company
NR 37
TC 4
Z9 4
U1 3
U2 33
PU ELSEVIER SCIENCE SA
PI LAUSANNE
PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND
SN 0040-6090
J9 THIN SOLID FILMS
JI Thin Solid Films
PD AUG 1
PY 2014
VL 564
BP 284
EP 293
DI 10.1016/j.tsf.2014.05.036
PG 10
WC Materials Science, Multidisciplinary; Materials Science, Coatings &
Films; Physics, Applied; Physics, Condensed Matter
SC Materials Science; Physics
GA AN8KD
UT WOS:000340852200039
ER
PT J
AU Crawford, KW
Wakabi, S
Kibuuka, H
Magala, F
Keshinro, B
Okoye, I
Akintunde, E
Hamm, TE
AF Crawford, Keith W.
Wakabi, Salim
Kibuuka, Hannah
Magala, Fred
Keshinro, Babajide
Okoye, Ifeanyi
Akintunde, Ezekiel
Hamm, Tiffany E.
TI Short Communication: East Meets West: A Description of HIV-1 Drug
Resistance Mutation Patterns of Patients Failing First Line Therapy in
PEPFAR Clinics from Uganda and Nigeria
SO AIDS RESEARCH AND HUMAN RETROVIRUSES
LA English
DT Article
ID ANTIRETROVIRAL THERAPY; REVERSE-TRANSCRIPTASE; VIROLOGICAL RESPONSE;
GENOTYPIC RESISTANCE; FAILURE; TYPE-1; SUSCEPTIBILITY; INDIVIDUALS;
PREDICTORS; EMERGENCE
AB HIV-1 viral load (VL) monitoring is recommended but seldom performed in resource-constrained countries. An evaluation of patients receiving first-line antiretroviral therapy in a multicountry PEPFAR program (RV288) was performed to determine the rates and predictors of virologic suppression. Resistance data from treatment failures are available from Uganda and Nigeria. Each country enrolled 325 subjects into this cross-sectional study. Subjects on first-line therapy were randomly selected for HIV RNA testing (viral load). Regimens included efavirenz or nevirapine with zidovudine/lamivudine or tenofovir/lamivudine. VL was determined from plasma using the Roche COBAS TaqMan HIV-1 Test, High Pure System v1.0 (47 copies/ml). Genotypic resistance testing was performed on samples with VL > 1,000 copies/ml. From Uganda, 85% of subjects were undetectable while 7%(23/325) had VL > 1,000 copies/ml. The HIV-1 subtype distribution was as follows: A = 47.6%, C = 14.3%, and D = 38.1%. No resistance mutations were found in 14% of subjects. All subjects with resistance had the M184V mutation. Of subjects failing a zidovudine regimen less than 1 year, 88% (7/8) had no thymidine analogue mutations (TAMs), compared to 50% (4/8) failing greater than 1 year. Four subjects (25%) hadmore than two mutations from the TAM-1pathway (41L, 210W, 215Y). In Nigeria, 82% were undetectable while 14% (45/325) had VL > 1,000 copies/ml. HIV-1 subtype distribution was as follows: 62.8% = CRF02_AG, 34% = pure G, and 2.8% = A. Of the 35 genotyped subjects, 14% (5/35) had no resistance mutations. Of the remainder, 10% (3/30) had no nucleoside analogue mutations while 33% (10/30) had only M184V along with nonnucleoside reverse transcriptase inhibitor (NNRTI) mutations. Forty percent (10/25) of subjects on zidovudine failed without TAMs. Another 25% (5/25) of subjects failing on zidovudine had more than two TAM-1 mutations. Individuals failing first-line antiretroviral therapy (ART) may retain sensitivity to one or more nucleoside analogues from the regimen. Knowledge of drug resistance patterns allow for selection of drugs that can be recycled in future regimens. Accumulation of resistance mutations may compromise future treatment options.
C1 [Crawford, Keith W.; Hamm, Tiffany E.] Walter Reed Army Inst Res, Global Hlth Programs, US Mil HIV Res Program MHRP, Bethesda, MD 20817 USA.
[Wakabi, Salim; Kibuuka, Hannah; Magala, Fred] MUWRP, Kampala, Uganda.
[Keshinro, Babajide; Okoye, Ifeanyi; Akintunde, Ezekiel] Nigeria Walter Reed Program, Abuja, Nigeria.
RP Crawford, KW (reprint author), Walter Reed Army Inst Res, Global Hlth Programs, US Mil HIV Res Program MHRP, 6720A Rockledge Dr,Suite 400, Bethesda, MD 20817 USA.
EM kwcrawford1@gmail.com
FU Henry M. Jackson Foundation for the Advancement of Military Medicine,
Inc. [W81XWH-07-2-0067]; U.S. Department of Defense (DoD)
[W81XWH-07-2-0067]
FX This work was supported by a cooperative agreement (W81XWH-07-2-0067)
between the Henry M. Jackson Foundation for the Advancement of Military
Medicine, Inc. and the U.S. Department of Defense (DoD). The views
expressed are those of the authors and should not be construed to
represent the positions of the U.S. Army or DoD.
NR 19
TC 1
Z9 1
U1 0
U2 3
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0889-2229
EI 1931-8405
J9 AIDS RES HUM RETROV
JI Aids Res. Hum. Retrovir.
PD AUG
PY 2014
VL 30
IS 8
BP 796
EP 799
DI 10.1089/aid.2013.0294
PG 4
WC Immunology; Infectious Diseases; Virology
SC Immunology; Infectious Diseases; Virology
GA AN4DX
UT WOS:000340538900011
PM 24798614
ER
PT J
AU Marks, CE
Glen, AG
Robinson, MW
Leemis, LM
AF Marks, Christopher E.
Glen, Andrew G.
Robinson, Matthew W.
Leemis, Lawrence M.
TI Applying Bootstrap Methods to System Reliability
SO AMERICAN STATISTICIAN
LA English
DT Article
DE Bias; Bootstrapping; Parametric lifetime distributions
AB We present a fully enumerated bootstrap method to find the empirical system lifetime distribution for a coherent system modeled by a reliability block diagram. Given failure data for individual components of a coherent system, the bootstrap empirical system lifetime distribution derived here will be free of resampling error. We further derive distribution-free expressions for the bias associated with the bootstrap method for estimating the mean system lifetimes of parallel and series systems with statistically identical components. We show that bootstrapping underestimates the mean system lifetime for parallel systems and overestimates the mean system lifetime for series systems, although both bootstrap estimates are asymptotically unbiased. The expressions for the bias are evaluated for several popular parametric lifetime distributions. Supplementary materials for this article are available online.
C1 [Marks, Christopher E.; Glen, Andrew G.] US Mil Acad, West Point, NY 10996 USA.
[Robinson, Matthew W.] US Army, Washington, DC USA.
[Leemis, Lawrence M.] Coll William & Mary, Dept Math, Williamsburg, VA 23187 USA.
RP Marks, CE (reprint author), US Mil Acad, West Point, NY 10996 USA.
EM cemarks@nps.edu; Andrew.Glen.1984@gmail.com; mthw.wm.robinson@gmail.com;
leemis@math.wm.edu
NR 10
TC 0
Z9 3
U1 0
U2 3
PU AMER STATISTICAL ASSOC
PI ALEXANDRIA
PA 732 N WASHINGTON ST, ALEXANDRIA, VA 22314-1943 USA
SN 0003-1305
EI 1537-2731
J9 AM STAT
JI Am. Stat.
PD AUG
PY 2014
VL 68
IS 3
BP 174
EP 182
DI 10.1080/00031305.2014.928232
PG 9
WC Statistics & Probability
SC Mathematics
GA AN2NQ
UT WOS:000340423000005
ER
PT J
AU Harmon, AR
Kennedy, AJ
Poda, AR
Bednar, AJ
Chappell, MA
Steevens, JA
AF Harmon, Ashley R.
Kennedy, Alan J.
Poda, Aimee R.
Bednar, Anthony J.
Chappell, Mark A.
Steevens, Jeffery A.
TI DETERMINATION OF NANOSILVER DISSOLUTION KINETICS AND TOXICITY IN AN
ENVIRONMENTALLY RELEVANT AQUEOUS MEDIUM
SO ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY
LA English
DT Article
DE Silver nanoparticles; Dissolution kinetics; Ionic strength; Ecotoxicity
effects
ID COATED SILVER NANOPARTICLES; ION-RELEASE KINETICS; AGGREGATION KINETICS;
BEHAVIOR; ECOTOXICITY; DISPERSION; STABILITY; EXPOSURE; NANOMATERIALS;
MODEL
AB Assessing the dissolution of silver nanoparticles (AgNPs) in laboratory test media and in the aquatic environment is critical for determining toxicity. In the present study, the ion-release kinetics for 20-nm, 50-nm, and 80-nm AgNPs in environmentally relevant freshwaters with different electrical conductivity values (30 mu S/cm, 150 mu S/cm) were examined and related to the associated impact on Daphnia magna. The acute toxicity of the AgNP suspensions to D. magna was assessed after 0 d and 7 d of interaction time between the particles and test media. When 48-h lethal median concentrations were expressed as total silver, D. magna was more sensitive to AgNPs suspended in low ionic strength media relative to higher ionic strength media, with the exception of 50-nm AgNPs suspended in the 150-mu S/cm medium. A 3.3-fold increase in hydrodynamic diameter measured by dynamic light scattering and field flow fractionation was observed over time for 20-nm particles in the 150-mS/cm medium, but only a small increase in aggregation size for 50-nm and 80-nm particles (1.4-fold and 1.2-fold increase, respectively) was observed. At a lower conductivity of 30 mu S/cm, a 1.7-fold, 1.0-fold, and 1.2-fold increase in aggregation size was observed in the 20-nm, 50-nm, and 80-nm particles, respectively. Thus, the impact of higher conductivity test media on increased aggregation and decreased toxicity (after 7 d) was relatively greater for the smaller (20-nm) AgNP higher compared to the 50-80 nm AgNPs. Environ Toxicol Chem 2014; 33: 1783-1791. Published 2014 Wiley Periodicals, Inc. This article is a US Government work and, as such, is in the public domain in the United States of America.
C1 [Harmon, Ashley R.; Kennedy, Alan J.; Poda, Aimee R.; Bednar, Anthony J.; Chappell, Mark A.; Steevens, Jeffery A.] US Army Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA.
RP Harmon, AR (reprint author), US Army Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA.
EM ashley.harmon@usace.army.mil
RI Poda, Aimee/K-1905-2012
NR 36
TC 9
Z9 9
U1 3
U2 43
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0730-7268
EI 1552-8618
J9 ENVIRON TOXICOL CHEM
JI Environ. Toxicol. Chem.
PD AUG
PY 2014
VL 33
IS 8
BP 1783
EP 1791
DI 10.1002/etc.2616
PG 9
WC Environmental Sciences; Toxicology
SC Environmental Sciences & Ecology; Toxicology
GA AN4DD
UT WOS:000340536900016
PM 24753094
ER
PT J
AU Bruns, I
Lucas, D
Pinho, S
Ahmed, J
Lambert, M
Kunisaki, Y
Scheiermann, C
Poncz, M
Bergmann, A
Frenette, P
AF Bruns, Ingmar
Lucas, Daniel
Pinho, Sandra
Ahmed, Jalal
Lambert, Michele
Kunisaki, Yuya
Scheiermann, Christoph
Poncz, Mortimer
Bergmann, Aviv
Frenette, Paul
TI MEGAKARYOCYTES REGULATE HEMATOPOIETIC STEM CELL QUIESCENCE VIA CXCL4
SECRETION
SO EXPERIMENTAL HEMATOLOGY
LA English
DT Meeting Abstract
CT 43rd Annual Scientific Meeting of the
International-Society-for-Experimental-Hematology (ISEH)
CY AUG 21-24, 2014
CL Montreal, CANADA
SP Int Soc Expt Hematol
C1 [Bergmann, Aviv] AECOM, Dept Syst & Computat Biol, New York, NY USA.
[Bruns, Ingmar; Lucas, Daniel; Pinho, Sandra; Ahmed, Jalal; Kunisaki, Yuya; Scheiermann, Christoph; Frenette, Paul] AECOM, Ruth L & David S Gottesman Inst Stem Cell & Regen, New York, NY USA.
[Lambert, Michele; Poncz, Mortimer] USA, Childrens Hosp Philadelphia, Dept Med, Philadelphia, PA USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0301-472X
EI 1873-2399
J9 EXP HEMATOL
JI Exp. Hematol.
PD AUG
PY 2014
VL 42
IS 8
SU 1
MA O1025
BP S18
EP S18
PG 1
WC Hematology; Medicine, Research & Experimental
SC Hematology; Research & Experimental Medicine
GA AN1LF
UT WOS:000340344300053
ER
PT J
AU Wang, D
Al Amin, MT
Abdelzaher, T
Roth, D
Voss, CR
Kaplan, LM
Tratz, S
Laoudi, J
Briesch, D
AF Wang, Dong
Al Amin, Md Tanvir
Abdelzaher, Tarek
Roth, Dan
Voss, Clare R.
Kaplan, Lance M.
Tratz, Stephen
Laoudi, Jamal
Briesch, Douglas
TI Provenance-Assisted Classification in Social Networks
SO IEEE JOURNAL OF SELECTED TOPICS IN SIGNAL PROCESSING
LA English
DT Article
DE Social signals; classification; uncertain provenance; maximum likelihood
estimation; expectation maximization; signal feature extraction
ID EM ALGORITHM
AB Signal feature extraction and classification are two common tasks in the signal processing literature. This paper investigates the use of source identities as a common mechanism for enhancing the classification accuracy of social signals. We define social signals as outputs, such as microblog entries, geotags, or uploaded images, contributed by users in a social network. Many classification tasks can be defined on such outputs. For example, one may want to identify the dialect of a microblog contributed by an author, or classify information referred to in a user's tweet as true or false. While the design of such classifiers is application-specific, social signals share in common one key property: they are augmented by the explicit identity of the source. This motivates investigating whether or not knowing the source of each signal (in addition to exploiting signal features) allows the classification accuracy to be improved. We call it provenance-assisted classification. This paper answers the above question affirmatively, demonstrating how source identities can improve classification accuracy, and derives confidence bounds to quantify the accuracy of results. Evaluation is performed in two real-world contexts: (i) fact-finding that classifies microblog entries into true and false, and (ii) language classification of tweets issued by a set of possibly multi-lingual speakers. We also carry out extensive simulation experiments to further evaluate the performance of the proposed classification scheme over different problem dimensions. The results show that provenance features significantly improve classification accuracy of social signals, even when no information is known about the sources (besides their ID). This observation offers a general mechanism for enhancing classification results in social networks.
C1 [Wang, Dong; Al Amin, Md Tanvir; Abdelzaher, Tarek; Roth, Dan] Univ Illinois, Dept Comp Sci, Urbana, IL 61801 USA.
[Voss, Clare R.; Kaplan, Lance M.; Tratz, Stephen; Laoudi, Jamal; Briesch, Douglas] US Army Res Lab, Adelphi, MD 20783 USA.
RP Wang, D (reprint author), Univ Illinois, Dept Comp Sci, Urbana, IL 61801 USA.
EM dwang24@illinois.edu; maamin2@illinois.edu; zaher@illinois.edu;
danr@illinois.edu; clare.r.voss.civ@mail.mil;
lance.m.kaplan.civ@mail.mil; stephen.c.tratz.civ@mail.mil;
jamal.laoudi.ctr@mail.mil; douglas.m.briesch.civ@mail.mil
FU Army Research Laboratory; [W911NF-09-2-0053]
FX This work was supported by the Army Research Laboratory and was
accomplished under Cooperative Agreement Number W911NF-09-2-0053. The
guest editor coordinating the review of this manuscript and approving it
for publication was Prof. Vikram Krishnamurthy.
NR 27
TC 5
Z9 5
U1 0
U2 3
PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
PI PISCATAWAY
PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA
SN 1932-4553
EI 1941-0484
J9 IEEE J-STSP
JI IEEE J. Sel. Top. Signal Process.
PD AUG
PY 2014
VL 8
IS 4
BP 624
EP 637
DI 10.1109/JSTSP.2014.2311586
PG 14
WC Engineering, Electrical & Electronic
SC Engineering
GA AN4AB
UT WOS:000340528900011
ER
PT J
AU Liao, DH
AF Liao, DaHan
TI Scattering and Imaging of Nonlinearly Loaded Antenna Structures in
Half-Space Environments
SO IEEE TRANSACTIONS ON ANTENNAS AND PROPAGATION
LA English
DT Article
DE Computational electromagnetics; harmonic balance; linear and nonlinear
electromagnetic scattering; method-of-moments; multistatic radar
imaging; radiowave propagation; remote sensing; subspace-based imaging
ID MULTIPLE SIGNAL CLASSIFICATION; MOM-AOM APPROACH; FREQUENCY-DOMAIN;
TRANSIENT-RESPONSE; EXTENDED TARGETS; HARMONIC RADAR; WIRE; ALGORITHMS;
SYSTEMS; ARRAYS
AB The electromagnetic scattering responses of nonlinearly loaded antenna structures excited by single-tone or multi-tone incident fields are considered in the frequency domain by employing a combination of the method-of-moments and a harmonic balance technique. Subsequently, standoff detection and localization of the scatterers in the presence of a half space is demonstrated with a subspace imaging procedure by exploiting the steady-state, multistatic harmonic scattering responses collected over an aspect-limited aperture. The attenuation rates of the harmonic scattered fields as a function of sensing range are investigated. The Green's function vector in the imaging functional is derived efficiently with the application of second-order-accurate asymptotic propagation techniques, and near-field imaging performance for single and multiple targets is also examined in the presence of noise and linear clutter. This study is intended to provide an analysis and simulation framework needed to facilitate the development of a complementary nonlinear detection capability for an existing near-ground, forward-looking linear imaging radar system.
C1 US Army Res Lab, Adelphi, MD 20783 USA.
RP Liao, DH (reprint author), US Army Res Lab, Adelphi, MD 20783 USA.
EM dahan.liao.civ@mail.mil
NR 39
TC 1
Z9 1
U1 0
U2 3
PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
PI PISCATAWAY
PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA
SN 0018-926X
EI 1558-2221
J9 IEEE T ANTENN PROPAG
JI IEEE Trans. Antennas Propag.
PD AUG
PY 2014
VL 62
IS 8
BP 4230
EP 4240
DI 10.1109/TAP.2014.2322875
PG 11
WC Engineering, Electrical & Electronic; Telecommunications
SC Engineering; Telecommunications
GA AN2XV
UT WOS:000340450200035
ER
PT J
AU Brozena, A
Buchanan, JH
Miles, RW
Williams, BR
Hulet, MS
AF Brozena, Ann
Buchanan, James H.
Miles, Ronald W., Jr.
Williams, Barry R.
Hulet, Melissa S.
TI Vapor Pressure of Triethyl and Tri-n-Propyl Phosphates and Diethyl
Malonate
SO JOURNAL OF CHEMICAL AND ENGINEERING DATA
LA English
DT Article
ID ORGANOPHOSPHORUS COMPOUNDS; TRIALKYL PHOSPHITES; CHEMICAL CONSTITUTION;
PHOSPHORUS PENTOXIDE; CHLORAMINE-T; PART I; ESTERS; ACIDS;
PHOSPHORYLATION; REACTIVITY
AB Triethyl phosphate (TEPO, CAS No. 78-40-0), tri-n-propyl phosphate (TPPO, CAS No. 513-08-6), and diethyl malonate (DEM, CAS No. 105-53-3) are of considerable interest to the chemical defense community as nontoxic simulants for toxic chemical warfare agents. Vapor pressure data have been measured for TEPO at T = (271.25 to 480.15) K, for TPPO at T = (263.15 to 527.61) K, and for DEM at T = (265.15 to 471.25) K using a variety of standard methods that have been modified as necessary. The new data extend the range of vapor pressure data previously reported in the literature for each of the title compounds to subambient temperatures and to lower pressures by approximately 3 orders of magnitude for TEPO, 5 orders of magnitude for TPPO, and 1 order of magnitude for DEM. Vapor pressure data and derived properties, including volatility and temperature-dependent heats of vaporization are reported for TEPO, TPPO, and DEM along with comparisons to chemical warfare agent materials.
C1 [Brozena, Ann; Buchanan, James H.; Miles, Ronald W., Jr.] US Army Res Dev & Engn Command, Edgewood Chem Biol Ctr, Aberdeen, MD 21010 USA.
[Williams, Barry R.; Hulet, Melissa S.] Leidos Corp, Gunpowder, MD 21010 USA.
RP Brozena, A (reprint author), US Army Res Dev & Engn Command, Edgewood Chem Biol Ctr, Aberdeen, MD 21010 USA.
EM ann.brozena.civ@mail.mil
NR 98
TC 2
Z9 2
U1 2
U2 14
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0021-9568
J9 J CHEM ENG DATA
JI J. Chem. Eng. Data
PD AUG
PY 2014
VL 59
IS 8
BP 2649
EP 2659
DI 10.1021/je500428d
PG 11
WC Thermodynamics; Chemistry, Multidisciplinary; Engineering, Chemical
SC Thermodynamics; Chemistry; Engineering
GA AN2UR
UT WOS:000340442000038
ER
PT J
AU Pelaez, M
Susin, C
Lee, J
Fiorini, T
Bisch, FC
Dixon, DR
McPherson, JC
Buxton, AN
Wikesjo, UME
AF Pelaez, Manuel
Susin, Cristiano
Lee, Jaebum
Fiorini, Tiago
Bisch, Frederick C.
Dixon, Douglas R.
McPherson, James C., III
Buxton, Amanda N.
Wikesjo, Ulf M. E.
TI Effect of rhBMP-2 dose on bone formation/maturation in a rat
critical-size calvarial defect model
SO JOURNAL OF CLINICAL PERIODONTOLOGY
LA English
DT Article
DE animal models; BMP-2; bone formation; bone maturation; calvarial bone;
dose
ID RICH PLASMA PREPARATION; MORPHOGENETIC PROTEIN-2; RIDGE AUGMENTATION;
RADIOGRAPHIC OBSERVATIONS; REGENERATION; IMPLANTS; CARRIER; SYSTEM; DOGS
AB Background: Application of recombinant human bone morphogenetic protein-2 (rhBMP-2) has been associated with significant adverse events in craniofacial settings, including swelling and seroma formation. Recent work has demonstrated an inverse relationship between bone formation/maturation and rhBMP-2 dose, frequency/severity of adverse events increasing with rising dose.
Objective: The objective of this study was to determine the most effective dose for rhBMP-2 soak-loaded onto an absorbable collagen sponge (ACS) carrier for bone formation/maturation using an established defect model.
Methods: One hundred sixty-eight outbred male Sprague-Dawley rats, age 11-13 weeks, weight 325-375 g randomized into seven groups of 24 subdivided into groups of eight, were used to provide radiographic and light microscopy observations of bone formation/maturation and aberrant healing events at 2, 4 and 8 weeks following application of rhBMP-2/ACS into critical-size, (sic)8-mm, through-through, calvarial osteotomy defects for a dose of 1.25, 2.5, 5.0, 10.0 and 20.0 mu g rhBMP-2/defect, or serve as ACS or sham-surgery controls.
Results: rhBMP-2 dosages >= 2.5 mu g/defect showed histological defect closure >90% within 2 weeks, and complete resolution within 4 weeks. Adverse healing events including swelling, excessive bone formation or seroma formation could not be determined with certainty in this defect model. Notably ACS control sites showed complete defect closure at the 8-week healing interval.
Conclusions: rhBMP-2/ACS accelerates local bone formation in the rat criticalsize through-through calvarial defect model once reaching an osteoinductive dose threshold. This threshold may already be reached at a 1.25-/2.5-mu g dose in this model. No further enhancement to bone formation/maturation may be observed adding rhBMP-2 above the 2.5-mu g dose. The 1.25-20.0 mu g dose range did not invoke appreciable aberrant healing events.
C1 [Pelaez, Manuel; Susin, Cristiano; Lee, Jaebum; Fiorini, Tiago; Wikesjo, Ulf M. E.] Georgia Regents Univ, Coll Dent Med, LAPCR, Augusta, GA 30912 USA.
[Pelaez, Manuel] US Army Dent Act, Ft Bragg, NC USA.
[Fiorini, Tiago] Fed Univ, Sch Dent, Sect Periodontol, Porto Alegre, RS, Brazil.
[Bisch, Frederick C.] US Army Adv Educ Program Periodont, Ft Gordon, GA USA.
[Dixon, Douglas R.] US Army Dent Act, West Point, NY USA.
[McPherson, James C., III] US Army, Dept Clin Invest, Ft Gordon, GA USA.
[Buxton, Amanda N.] Medtron Spine & Biol, Memphis, TN USA.
RP Wikesjo, UME (reprint author), Georgia Regents Univ, Coll Dent Med, LAPCR, 1120 Fifteenth St,GC 4265, Augusta, GA 30912 USA.
EM uwikesjo@gru.edu
RI Wikesjo, Ulf/A-4159-2009; Susin, Cristiano/B-9822-2008
OI Wikesjo, Ulf/0000-0003-1607-0583;
FU Medtronic Spine & Biologics, Memphis, TN, USA; Nobel Biocare AG
FX This study was supported in part by a grant from Medtronic Spine &
Biologics, Memphis, TN, USA. Drs. Cristiano Susin, Jaebum Lee and Ulf M.
E. Wikesjo are supported by a grant from Nobel Biocare AG. Dr. Amanda N.
Buxton is an employee of Medtronic Spine & Biologics. All other authors
claim no conflict of interest. The opinions expressed in this article do
not represent the views of the US Department of Defense, the Department
of the Army or the US Army Dental Corps. Use of any commercial products
in this project does not imply endorsement by the US Government.
NR 33
TC 10
Z9 10
U1 2
U2 5
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0303-6979
EI 1600-051X
J9 J CLIN PERIODONTOL
JI J. Clin. Periodontol.
PD AUG
PY 2014
VL 41
IS 8
BP 827
EP 836
DI 10.1111/jcpe.12270
PG 10
WC Dentistry, Oral Surgery & Medicine
SC Dentistry, Oral Surgery & Medicine
GA AN4FI
UT WOS:000340542600012
PM 24807100
ER
PT J
AU Ferguson, JB
Tabandeh-Khorshid, M
Mantas, JC
Rohatgi, PK
Cho, K
Kim, CS
AF Ferguson, J. B.
Tabandeh-Khorshid, Meysam
Mantas, John C.
Rohatgi, Pradeep K.
Cho, Kyu
Kim, Chang-Soo
TI Predicting the Effect of Pouring Temperature on the Crystallite Density,
Remelting, and Crystal Growth Kinetics in the Solidification of Aluminum
Alloys
SO METALLURGICAL AND MATERIALS TRANSACTIONS B-PROCESS METALLURGY AND
MATERIALS PROCESSING SCIENCE
LA English
DT Article
ID GRAIN-REFINEMENT; SIZE
AB In the present work, we developed an analytical model to describe the effect of pouring temperature on the crystallite density, remelting, growth kinetics, and the resultant final grain size for aluminum (Al)-based alloys synthesized using gravity casting. The model predicts that there are three regimes of pouring temperature/grain size-related behavior: (i) at low superheats, grain size is small and relatively constant; (ii) at intermediate levels of superheat, there appears to be a transitional behavior where grain size increases in a rapid, non-linear fashion; and (iii) at high superheats, grain size increases linearly with increasing temperature. This general pattern is expected to be shifted upward as distance from the bottom of the casting increases, which is likely a result of the slower cooling rates and/or longer solidification times with increasing distance from the bottom of the casting. To validate the model, a set of experiments has been conducted using Al-Cu and Al-Si alloys (i.e., Al-3.0 wt pct Cu, Al-4.5 wt pct Cu, and Al-A356.2 alloys), and the experimental measurements showed consistent results with theoretical predictions.
C1 [Ferguson, J. B.; Tabandeh-Khorshid, Meysam; Mantas, John C.; Rohatgi, Pradeep K.; Kim, Chang-Soo] Univ Wisconsin, Mat Sci & Engn Dept, Milwaukee, WI 53211 USA.
[Cho, Kyu] US Army Res Lab, Weap & Mat Res Directorate, Aberdeen, MD 21005 USA.
RP Ferguson, JB (reprint author), Univ Wisconsin, Mat Sci & Engn Dept, 3200 N Cramer St, Milwaukee, WI 53211 USA.
EM kimcs@uwm.edu
FU U.S. Army Research Laboratory [W911NF-08-2-0014]
FX This material is based upon work supported by the U.S. Army Research
Laboratory under Cooperative Agreement No. W911NF-08-2-0014. The views,
opinions, and conclusions made in this document are those of the authors
and should not be interpreted as representing the official policies,
either expressed or implied, of Army Research Laboratory or the U. S.
Government. The U. S. Government is authorized to reproduce and
distribute reprints for Government purposes notwithstanding any
copyright notation herein.
NR 15
TC 2
Z9 3
U1 2
U2 12
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1073-5615
EI 1543-1916
J9 METALL MATER TRANS B
JI Metall. Mater. Trans. B-Proc. Metall. Mater. Proc. Sci.
PD AUG
PY 2014
VL 45
IS 4
BP 1407
EP 1417
DI 10.1007/s11663-014-0044-9
PG 11
WC Materials Science, Multidisciplinary; Metallurgy & Metallurgical
Engineering
SC Materials Science; Metallurgy & Metallurgical Engineering
GA AN1SV
UT WOS:000340364800026
ER
PT J
AU Jiang, RZ
Tran, DT
McClure, JP
Chu, D
AF Jiang, Rongzhong
Tran, Dat T.
McClure, Joshua P.
Chu, Deryn
TI A Class of (Pd-Ni-P) Electrocatalysts for the Ethanol Oxidation Reaction
in Alkaline Media
SO ACS CATALYSIS
LA English
DT Article
DE Pd-Ni-P catalyst; ethanol electrooxidation; direct ethanol fuel cells;
kinetics and mechanisms of EOR; substitutional/interstitial alloy
ID OXYGEN REDUCTION REACTION; FORMIC-ACID ELECTROOXIDATION; ALCOHOL
FUEL-CELLS; METHANOL ELECTROOXIDATION; ANODE CATALYSTS; NANOPARTICLES;
PERFORMANCE; NANOALLOY; PALLADIUM; TEMPLATE
AB A class of Pd-Ni-P electrocatalysts are prepared for the ethanol electrooxidation reaction (EOR). X-ray diffraction and transmission electron microscope reveal that the synthesized Pd-Ni-P catalyst possesses a more amorphous structure with smaller particle sizes when compared with a Pd-Ni sample without P and a control Pd black (Pd-blk) sample. The Pd-Ni-P catalyst contains double the number of electrocatalytically active sites (12.03%) compared with the Pd-Ni (6.04%) and Pd-blk (5.12%) samples. For the EOR, the Pd-Ni-P catalyst has the lowest onset potential (-0.88 V vs SCE), the most negative peak potential (-0.27 V vs SCE), and the highest EOR activity in 0.1 M KOH solution. Moreover, a 110 mV decrease in overpotential is observed for the EOR on the Pd-Ni-P catalyst compared with the Pd-blk catalyst. A Tafel slope of 60 mV/dec at low polarization potentials (<-0.76 V vs SCE) was obtained for EOR at a Pd-Ni-P-coated electrode with a reaction rate constant of 2.8 x 10(-4) cm.S-1.M-1 at -0.3 V vs SCE in KOH media. Finally, we find that the electrooxidation of ethanol on the Pd-Ni-P catalyst undergoes a 4-electron process to acetate.
C1 [Jiang, Rongzhong; Tran, Dat T.; McClure, Joshua P.; Chu, Deryn] US Army Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA.
RP Jiang, RZ (reprint author), US Army Res Lab, Sensors & Electron Devices Directorate, 2800 Powder Mill Rd, Adelphi, MD 20783 USA.
EM Rongzhong.jiang.civ@mail.mil
FU U.S. Department of the Army; U.S. Army Materiel Command
FX The authors would like to thank Dr. Panju Shang at University of
Maryland for assisting TEM analysis. Thanks to Dr. Cynthia Lundgren for
helpful discussions. Finally, thanks to the U.S. Department of the Army
and U.S. Army Materiel Command for supporting this work.
NR 45
TC 31
Z9 31
U1 10
U2 113
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 2155-5435
J9 ACS CATAL
JI ACS Catal.
PD AUG
PY 2014
VL 4
IS 8
BP 2577
EP 2586
DI 10.1021/cs500462z
PG 10
WC Chemistry, Physical
SC Chemistry
GA AM6OF
UT WOS:000339983800020
ER
PT J
AU Ganem, VJ
Mora, A
Varney, SM
Bebarta, VS
AF Ganem, V. J.
Mora, A.
Varney, S. M.
Bebarta, V. S.
TI An analysis of opioid prescribing practices for non-chronic pain by
emergency department providers
SO CLINICAL TOXICOLOGY
LA English
DT Meeting Abstract
DE Opioid; Non-chronic Pain; Emergency Department
C1 [Ganem, V. J.; Varney, S. M.; Bebarta, V. S.] San Antonio Mil Med Ctr, San Antonio, TX USA.
[Mora, A.] US Army Inst Surg Res, San Antonio, TX USA.
RI Bebarta, Vikhyat/M-1513-2015; bebarta, vikhyat/K-3476-2015
NR 0
TC 0
Z9 0
U1 0
U2 1
PU INFORMA HEALTHCARE
PI NEW YORK
PA 52 VANDERBILT AVE, NEW YORK, NY 10017 USA
SN 1556-3650
EI 1556-9519
J9 CLIN TOXICOL
JI Clin. Toxicol.
PD AUG
PY 2014
VL 52
IS 7
MA 234
BP 788
EP 788
PG 1
WC Toxicology
SC Toxicology
GA AN0UE
UT WOS:000340298700240
ER
PT J
AU Smith, ML
Nichols, DC
Underwood, P
Fuller, Z
Moser, MA
LoDico, C
Gorelick, DA
Newmeyer, MN
Concheiro, M
Huestis, MA
AF Smith, Michael L.
Nichols, Daniel C.
Underwood, Paula
Fuller, Zachary
Moser, Matthew A.
LoDico, Charles
Gorelick, David A.
Newmeyer, Matthew N.
Concheiro, Marta
Huestis, Marilyn A.
TI Morphine and codeine concentrations in human urine following controlled
poppy seeds administration of known opiate content
SO FORENSIC SCIENCE INTERNATIONAL
LA English
DT Article
DE Poppy seeds; Urine; Morphine; Codeine; Controlled dose
ID 6-ACETYLMORPHINE; CONSUMPTION
AB Opiates are an important component for drug testing due to their high abuse potential. Proper urine opiate interpretation includes ruling out poppy seed ingestion; however, detailed elimination studies after controlled poppy seed administration with known morphine and codeine doses are not available. Therefore, we investigated urine opiate pharmacokinetics after controlled oral administration of uncooked poppy seeds with known morphine and codeine content. Participants were administered two 45 g oral poppy seed doses 8 h apart, each containing 15.7 mg morphine and 3 mg codeine. Urine was collected ad libitum up to 32 h after the first dose. Specimens were analyzed with the Roche Opiates II immunoassay at 2000 and 300 mu g/L cutoffs, and the ThermoFisher CEDIA (R) heroin metabolite (6-acetylmorphine, 6-AM) and Lin-Zhi 6-AM immunoassays with 10 mu g/L cutoffs to determine if poppy seed ingestion could produce positive results in these heroin marker assays. In addition, all specimens were quantified for morphine and codeine by GC/MS. Participants (N = 22) provided 391 urine specimens over 32 h following dosing; 26.6% and 83.4% were positive for morphine at 2000 and 300 mu g/L GC/MS cutoffs, respectively. For the 19 subjects who completed the study, morphine concentrations ranged from <300 to 7522 mu g/L with a median peak concentration of 5239 mu g/L. The median first morphine-positive urine sample at 2000 mu g/L cutoff concentration occurred at 6.6 h (1.2-12.1), with the last positive from 2.6 to 18 h after the second dose. No specimens were positive for codeine at a cutoff concentration of 2000 mu g/L, but 20.2% exceeded 300 mu g/L, with peak concentrations of 658 mu g/L (284-1540). The Roche Opiates II immunoassay had efficiencies greater than 96% for the 2000 and 300 mu g/L cutoffs. The CEDIA 6-AM immunoassay had a specificity of 91%, while the Lin-Zhi assay had no false positive results. These data provide valuable information for interpreting urine opiate results. (C) 2014 Published by Elsevier Ireland Ltd.
C1 [Smith, Michael L.; Nichols, Daniel C.; Underwood, Paula; Fuller, Zachary; Moser, Matthew A.] US Army, Forens Toxicol Drug Testing Lab, Ft George G Meade, MD USA.
[LoDico, Charles] Dept Hlth & Human Serv, Abuse Mental Hlth Serv Adm, Div Workplace Programs, Rockville, MD USA.
[Gorelick, David A.; Newmeyer, Matthew N.; Concheiro, Marta; Huestis, Marilyn A.] NIDA, Intramural Res Program, NIH, Baltimore, MD 21224 USA.
[Gorelick, David A.] Univ Maryland, Sch Med, Dept Psychiat, Baltimore, MD 21201 USA.
[Newmeyer, Matthew N.] Univ Maryland, Toxicol Program, Baltimore, MD 21201 USA.
RP Huestis, MA (reprint author), NIDA, Intramural Res Program, NIH, 251 Bayview Blvd,Suite 200,Rm O5A-721, Baltimore, MD 21224 USA.
EM mhuestis@intra.nida.nih.gov
OI Concheiro, Marta/0000-0002-3858-1280; Newmeyer,
Matthew/0000-0002-0653-1553
FU Intramural Research Program of the National Institutes of Health,
National Institute on Drug Abuse; Division of Workplace Programs,
Substance Abuse Mental Health Services Administration, USA
FX This work was supported by the Intramural Research Program of the
National Institutes of Health, National Institute on Drug Abuse and the
Division of Workplace Programs, Substance Abuse Mental Health Services
Administration, USA. The opinions in this article are those of the
authors and do not necessarily reflect the views of the United States
Department of Army or Department of Defense.
NR 15
TC 8
Z9 8
U1 0
U2 33
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
IRELAND
SN 0379-0738
EI 1872-6283
J9 FORENSIC SCI INT
JI Forensic Sci.Int.
PD AUG
PY 2014
VL 241
BP 87
EP 90
DI 10.1016/j.forsciint.2014.04.042
PG 4
WC Medicine, Legal
SC Legal Medicine
GA AM7KU
UT WOS:000340046700018
PM 24887324
ER
PT J
AU Lu, Z
Wang, WY
Wang, C
AF Lu, Zhuo
Wang, Wenye
Wang, Cliff
TI Modeling, Evaluation and Detection of Jamming Attacks in Time-Critical
Wireless Applications
SO IEEE TRANSACTIONS ON MOBILE COMPUTING
LA English
DT Article
DE Performance modeling; wireless network; time-critical messaging; jamming
attack detection; smart grid applications
ID SERVICE ATTACKS; NETWORKS; COMMUNICATION
AB Recently, wireless networking for emerging cyber-physical systems, in particular the smart grid, has been drawing increasing attention in that it has broad applications for time-critical message delivery among electronic devices on physical infrastructures. However, the shared nature of wireless channels unavoidably exposes the messages in transit to jamming attacks, which broadcast radio interference to affect the network availability of electronic equipments. An important, yet open research question is how to model and detect jamming attacks in such wireless networks, where communication traffic is more time-critical than that in conventional data-service networks, such as cellular and WiFi networks. In this paper, we aim at modeling and detecting jamming attacks against time-critical wireless networks with applications to the smart grid. In contrast to communication networks where packets-oriented metrics, such as packet loss and throughput are used to measure the network performance, we introduce a new metric, message invalidation ratio, to quantify the performance of time-critical applications. Our modeling approach is inspired by the similarity between the behavior of a jammer who attempts to disrupt the delivery of a time-critical message and the behavior of a gambler who intends to win a gambling game. Therefore, by gambling-based modeling and real-time experiments, we find that there exists a phase transition phenomenon for successful time-critical message delivery under a variety of jamming attacks. That is, as the probability that a packet is jammed increases from 0 to 1, the message invalidation ratio first increases slightly, then increases dramatically to 1. Based on analytical and experimental results, we design the Jamming Attack Detection based on Estimation (JADE) scheme to achieve robust jamming detection, and implement JADE in a wireless network for power substations in the smart grid.
C1 [Lu, Zhuo; Wang, Wenye] N Carolina State Univ, Dept Elect & Comp Engn, Raleigh, NC 27695 USA.
[Wang, Cliff] Army Res Off, Res Triangle Pk, NC 27709 USA.
RP Lu, Z (reprint author), N Carolina State Univ, Dept Elect & Comp Engn, Raleigh, NC 27695 USA.
EM zlu3@ncsu.edu; wwang@ncsu.edu; cliff.wang@us.army.mil
FU Army Research Office (ARO) staff research [W911NF-07-R-0001-05]; Defense
Threat Reduction Agency (DTRA) research [HDTRA1-08-1-0024]
FX The work was supported by the Army Research Office (ARO) staff research
grant W911NF-07-R-0001-05 and the Defense Threat Reduction Agency (DTRA)
research grant HDTRA1-08-1-0024. An earlier version of the work was
published in IEEE INFOCOM 2011.
NR 31
TC 10
Z9 10
U1 3
U2 21
PU IEEE COMPUTER SOC
PI LOS ALAMITOS
PA 10662 LOS VAQUEROS CIRCLE, PO BOX 3014, LOS ALAMITOS, CA 90720-1314 USA
SN 1536-1233
EI 1558-0660
J9 IEEE T MOBILE COMPUT
JI IEEE. Trans. Mob. Comput.
PD AUG
PY 2014
VL 13
IS 8
BP 1746
EP 1759
DI 10.1109/TMC.2013.146
PG 14
WC Computer Science, Information Systems; Telecommunications
SC Computer Science; Telecommunications
GA AM8EM
UT WOS:000340104100008
ER
PT J
AU Krueger, CA
Wenke, JC
AF Krueger, Chad A.
Wenke, Joseph C.
TI Initial injury severity and social factors determine ability to deploy
after combat-related amputation
SO INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
LA English
DT Article
DE Amputee deployment; Amputee activity; Amputee level of function; Mangled
extremity; Amputation
ID LOWER-EXTREMITY TRAUMA; LOWER-LIMB AMPUTATION; PHYSICAL-ACTIVITY;
AMPUTEES; PARTICIPATION; RETURN; SALVAGE; WORK; DISABILITY; METAANALYSIS
AB Objective: While many recent publications have examined the ability of amputees to return to active duty, it remains largely unknown why few amputees deploy after amputation and many amputees do not. The purpose of this study is to examine what predictor(s) exist for whether or not an amputee will deploy after sustaining a combat-related amputation.
Methods: All U. S. Service members who sustained major extremity amputations from September 2001 through July 2011 were analysed. Amputation level(s), mechanism of injury, time interval to amputation, age, rank, Physical Evaluation Board (PEB) disposition and ability to deploy after amputation were determined.
Results: Deployment information after amputation was obtained for 953 amputees. There were 47 (5%) amputees who deployed. There were no significant differences amongst service branches for the deployment of amputees (p > 0.2). Amputees who underwent their amputation on the same day of their injury were significantly less likely to deploy after amputation than those who had their amputation on the day of injury (p = .01). Deployed amputees had significantly lower Injury Severity Scores than amputees who did not deploy (15.98 vs 20.87, p < 0.01) and officers were significantly (p < .01) more likely to deploy and the average age of amputees who deployed was significantly higher than those who did not (27.5 vs 25.1, p < .01). Lastly, those amputees who sustained a transtibial amputation were significantly more likely to deploy than all other amputation levels (p < .01). Nine out of 19 (47%) Special Forces amputees were able to deploy.
Discussion: The vast majority of amputees do not able to deploy after undergoing amputation. The main predictors of deploying after sustaining a combat-related amputation appear to be: sustaining a transtibial amputation, being of senior rank or age and being a member of the Special Forces. Many of these factors appear to be non-treatment related and highlight the importance that individual and social factors play in the recovery of severe injuries. Published by Elsevier Ltd.
C1 [Krueger, Chad A.] San Antonio Mil Med Ctr, Ft Sam Houston, TX USA.
[Wenke, Joseph C.] US Army Inst Surg Res, Ft Sam Houston, TX USA.
RP Krueger, CA (reprint author), Brooke Army Med Ctr, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA.
EM chad.a.krueger4.mil@mail.mil; joseph.c.wenke.civ@mail.mil
NR 33
TC 3
Z9 3
U1 4
U2 14
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0020-1383
EI 1879-0267
J9 INJURY
JI Injury-Int. J. Care Inj.
PD AUG
PY 2014
VL 45
IS 8
BP 1231
EP 1235
DI 10.1016/j.injury.2014.02.008
PG 5
WC Critical Care Medicine; Emergency Medicine; Orthopedics; Surgery
SC General & Internal Medicine; Emergency Medicine; Orthopedics; Surgery
GA AN0MU
UT WOS:000340279500016
PM 24613612
ER
PT J
AU Rao, PM
Walter, TR
Sankar, B
Subhash, G
Yen, CF
AF Rao, Prabhakar M.
Walter, Timothy R.
Sankar, Bhavani
Subhash, Ghatu
Yen, Chian F.
TI Analysis of failure modes in three-dimensional woven composites
subjected to quasi-static indentation
SO JOURNAL OF COMPOSITE MATERIALS
LA English
DT Article
DE 3D Woven composites; indentation mechanics; anisotropic yielding;
failure modes; delamination cracking
ID LOW-VELOCITY IMPACT; TEXTILE COMPOSITES; BINARY MODEL; DAMAGE; 2D;
DELAMINATION; RESISTANCE; STRENGTH; BEHAVIOR; STRESS
AB Finite element models are developed to predict potential failure initiation sites and associated failure modes in S2-Glass/SC15 three-dimensional (3D) woven composites under quasi-static indentation. As part of this modeling effort, experimental micrographs of the composite specimen obtained from a previous experimental study(1,2) are analyzed. In conjunction with these micrographs, model outcomes demonstrate the ability of warp weavers or through-thickness Z-yarns to shield inter-laminar cracks. Quasi-static indentation is modeled as a contact interaction between a rigid cylindrical indenter and a deformable S2-Glass/SC15 3D woven composite laminate using ABAQUS (R). Tow elements are modeled as transversely isotropic elastic-plastic material entities, whereas the inter-tow matrix is modeled as an isotropic elastic-plastic material. Through-thickness failure modes are predicted based on the Tsai-Hill criterion. Contour maps of these failure modes point to the location and corresponding damage initiation mode within the material. Experimentally obtained micrographs 1,2 are then analyzed on the basis of these contour maps, thereby serving to validate the modeling methodology. The effect of Z-yarns is demonstrated with the aid of two-dimensional plane strain linear elastic fracture mechanics analysis. Crack shielding abilities of the Z-yarns manifest as the variation of strain energy release rate as a function of crack length and location. In the vicinity of a Z-yarn, the energy release rate decreases precipitously, indicating the inability of the crack to penetrate the Z-yarns.
C1 [Rao, Prabhakar M.] United Technol Res Ctr, Solid Mech Grp, Dept Phys Sci, E Hartford, CT 06108 USA.
[Walter, Timothy R.; Sankar, Bhavani; Subhash, Ghatu] Univ Florida, Dept Mech & Aerosp Engn, Gainesville, FL USA.
[Yen, Chian F.] US Army, Res Lab, Aberdeen Proving Ground, MD USA.
RP Rao, PM (reprint author), United Technol Res Ctr, Solid Mech Grp, Dept Phys Sci, 411 Silver Lane,MS 129-73, E Hartford, CT 06108 USA.
EM raomp@utrc.utc.com
RI Walter, Thomas/K-4857-2015
FU United States Army Research Office [W911NF-08-1-0120]; United States
Army Research Laboratory (ARL)
FX The funding for this work was provided by the United States Army
Research Office (Grant number W911NF-08-1-0120), with Dr Bruce LaMattina
as the Program Manager and the United States Army Research Laboratory
(ARL). The authors are grateful for the financial support.
NR 35
TC 0
Z9 0
U1 1
U2 20
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 0021-9983
EI 1530-793X
J9 J COMPOS MATER
JI J. Compos Mater.
PD AUG
PY 2014
VL 48
IS 20
BP 2473
EP 2491
DI 10.1177/0021998313499950
PG 19
WC Materials Science, Composites
SC Materials Science
GA AM9ND
UT WOS:000340207400004
ER
PT J
AU Jordan, JB
Naito, CJ
Haque, BZ
AF Jordan, Joseph B.
Naito, Clay J.
Haque, Bazle Z. (Gama)
TI Quasi-static, low-velocity impact and ballistic impact behavior of plain
weave E-glass/phenolic composites
SO JOURNAL OF COMPOSITE MATERIALS
LA English
DT Article
DE Material properties; low-velocity impact (LVI); E-glass/phenolic;
ballistic limit; depth of penetration
ID PENETRATION
AB Quasi-static, low-velocity impact (LVI) and ballistic impact loading conditions were used to find the material properties and dynamic responses of E-glass/phenolic composites. Standard American Society for Testing and Materials (ASTM) tests were used to find the density, Poisson's ratio, tensile, compressive and shear strengths, and the elastic and shear moduli of the material. The quasi-static punch shear and crush strength tests were used to find the punch shear and crush strengths of the material. LVI tests were conducted to obtain force versus time curves for various loading conditions. Ballistic testing was conducted using a right circular cylinder (RCC) to find the V-50 ballistic limit and the depth of penetration of the RCC at various impact velocities. The experimental results of this investigation can be used for structural design and to validate numerical solutions for both LVI and ballistic impact events.
C1 [Jordan, Joseph B.] US Army, Engn Res & Dev Ctr, Survivabil Engn Branch, APO, AE USA.
[Naito, Clay J.] Lehigh Univ, Dept Civil Engn, Bethlehem, PA USA.
[Haque, Bazle Z. (Gama)] UD CCM, Newark, DE USA.
RP Jordan, JB (reprint author), US Army, Engn Res & Dev Ctr, APO, AE 09630 USA.
EM joseph.b.jordan@usace.army.mil
OI Naito, Clay/0000-0003-3835-8131
NR 25
TC 3
Z9 3
U1 2
U2 9
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 0021-9983
EI 1530-793X
J9 J COMPOS MATER
JI J. Compos Mater.
PD AUG
PY 2014
VL 48
IS 20
BP 2505
EP 2516
DI 10.1177/0021998313499952
PG 12
WC Materials Science, Composites
SC Materials Science
GA AM9ND
UT WOS:000340207400006
ER
PT J
AU Hairston, WD
Whitaker, KW
Ries, AJ
Vettel, JM
Bradford, JC
Kerick, SE
McDowell, K
AF Hairston, W. David
Whitaker, Keith W.
Ries, Anthony J.
Vettel, Jean M.
Bradford, J. Cortney
Kerick, Scott E.
McDowell, Kaleb
TI Usability of four commercially-oriented EEG systems
SO JOURNAL OF NEURAL ENGINEERING
LA English
DT Article
DE EEG; neuroimaging; system comparison; real-world
ID WIRELESS EEG; WALKING; CLASSIFICATION; ELECTRODE; SIGNALS; MOBILE
AB Electroencephalography ( EEG) holds promise as a neuroimaging technology that can be used to understand how the human brain functions in real-world, operational settings while individuals move freely in perceptually-rich environments. In recent years, several EEG systems have been developed that aim to increase the usability of the neuroimaging technology in real-world settings. Here, the usability of three wireless EEG systems from different companies are compared to a conventional wired EEG system, BioSemi's ActiveTwo, which serves as an established laboratory-grade 'gold standard' baseline. The wireless systems compared include Advanced Brain Monitoring's B-Alert X10, Emotiv Systems' EPOC and the 2009 version of QUASAR's Dry Sensor Interface 10-20. The design of each wireless system is discussed in relation to its impact on the system's usability as a potential real-world neuroimaging system. Evaluations are based on having participants complete a series of cognitive tasks while wearing each of the EEG acquisition systems. This report focuses on the system design, usability factors and participant comfort issues that arise during the experimental sessions. In particular, the EEG systems are assessed on five design elements: adaptability of the system for differing head sizes, subject comfort and preference, variance in scalp locations for the recording electrodes, stability of the electrical connection between the scalp and electrode, and timing integration between the EEG system, the stimulus presentation computer and other external events.
C1 [Hairston, W. David; Whitaker, Keith W.; Ries, Anthony J.; Vettel, Jean M.; Bradford, J. Cortney; Kerick, Scott E.; McDowell, Kaleb] US Army Res Lab, Human Res & Engn Directorate, Translat Neurosci Branch, Aberdeen Proving Ground, MD 21001 USA.
[Bradford, J. Cortney] Univ Michigan, Sch Kinesiol, Human Neuromech Lab, Ann Arbor, MI 48109 USA.
RP Hairston, WD (reprint author), US Army Res Lab, Human Res & Engn Directorate, Translat Neurosci Branch, Aberdeen Proving Ground, MD 21001 USA.
EM william.d.hairston4.civ@mail.mil
OI Hairston, W. David/0000-0003-4432-8430
NR 40
TC 19
Z9 19
U1 3
U2 40
PU IOP PUBLISHING LTD
PI BRISTOL
PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND
SN 1741-2560
EI 1741-2552
J9 J NEURAL ENG
JI J. Neural Eng.
PD AUG
PY 2014
VL 11
IS 4
AR 046018
DI 10.1088/1741-2560/11/4/046018
PG 14
WC Engineering, Biomedical; Neurosciences
SC Engineering; Neurosciences & Neurology
GA AM7KS
UT WOS:000340046500018
ER
PT J
AU Jangraw, DC
Wang, J
Lance, BJ
Chang, SF
Sajda, P
AF Jangraw, David C.
Wang, Jun
Lance, Brent J.
Chang, Shih-Fu
Sajda, Paul
TI Neurally and ocularly informed graph-based models for searching 3D
environments
SO JOURNAL OF NEURAL ENGINEERING
LA English
DT Article
DE brain-computer interface; EEG; eye tracking; pupillometry; computer
vision
ID BRAIN-COMPUTER INTERFACE; INDEPENDENT COMPONENT ANALYSIS;
FIXATION-RELATED POTENTIALS; EYE-MOVEMENTS; VISUAL-SEARCH; PUPIL SIZE;
EEG; TRACKING; ARTIFACT; VISION
AB Objective. As we move through an environment, we are constantly making assessments, judgments and decisions about the things we encounter. Some are acted upon immediately, but many more become mental notes or fleeting impressions-our implicit 'labeling' of the world. In this paper, we use physiological correlates of this labeling to construct a hybrid brain-computer interface (hBCI) system for efficient navigation of a 3D environment. Approach. First, we record electroencephalographic (EEG), saccadic and pupillary data from subjects as they move through a small part of a 3D virtual city under free-viewing conditions. Using machine learning, we integrate the neural and ocular signals evoked by the objects they encounter to infer which ones are of subjective interest to them. These inferred labels are propagated through a large computer vision graph of objects in the city, using semi-supervised learning to identify other, unseen objects that are visually similar to the labeled ones. Finally, the system plots an efficient route to help the subjects visit the 'similar' objects it identifies. Main results. We show that by exploiting the subjects' implicit labeling to find objects of interest instead of exploring naively, the median search precision is increased from 25% to 97%, and the median subject need only travel 40% of the distance to see 84% of the objects of interest. We also find that the neural and ocular signals contribute in a complementary fashion to the classifiers' inference of subjects' implicit labeling. Significance. In summary, we show that neural and ocular signals reflecting subjective assessment of objects in a 3D environment can be used to inform a graph-based learning model of that environment, resulting in an hBCI system that improves navigation and information delivery specific to the user's interests.
C1 [Jangraw, David C.; Sajda, Paul] Columbia Univ, Dept Biomed Engn, New York, NY 10027 USA.
[Wang, Jun; Chang, Shih-Fu; Sajda, Paul] Columbia Univ, Dept Elect Engn, New York, NY 10027 USA.
[Lance, Brent J.] US Army, Res Lab, Translat Neurosci Branch, Human Res & Engn Directorate, Aberdeen Proving Ground, MD 21001 USA.
[Chang, Shih-Fu] Columbia Univ, Dept Comp Sci, New York, NY 10027 USA.
[Sajda, Paul] Columbia Univ, Dept Radiol, New York, NY 10027 USA.
RP Jangraw, DC (reprint author), Columbia Univ, Dept Biomed Engn, New York, NY 10027 USA.
EM psajda@columbia.edu
FU Army Research Laboratory [W911NF-10-2-0022]
FX The authors would like to thank Ansh Johri and Meron Gribetz for their
invaluable work refining the virtual environments and developing the
route traversal scripts. Research was sponsored by the Army Research
Laboratory and was accomplished under Cooperative Agreement Number
W911NF-10-2-0022. The views and conclusions contained in this document
are those of the authors and should not be interpreted as representing
the official policies, either expressed or implied, of the Army Research
Laboratory of the US Government. The US Government is authorized to
reproduce and distribute reprints for Government purposes
notwithstanding any copyright notation herein.
NR 54
TC 8
Z9 8
U1 3
U2 14
PU IOP PUBLISHING LTD
PI BRISTOL
PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND
SN 1741-2560
EI 1741-2552
J9 J NEURAL ENG
JI J. Neural Eng.
PD AUG
PY 2014
VL 11
IS 4
AR 046003
DI 10.1088/1741-2560/11/4/046003
PG 12
WC Engineering, Biomedical; Neurosciences
SC Engineering; Neurosciences & Neurology
GA AM7KS
UT WOS:000340046500003
PM 24891496
ER
PT J
AU Davis, JS
Satahoo, SS
Butler, FK
Dermer, H
Naranjo, D
Julien, K
Van Haren, RM
Namias, N
Blackbourne, LH
Schulman, CI
AF Davis, James S.
Satahoo, Shevonne S.
Butler, Frank K.
Dermer, Harrison
Naranjo, Daniel
Julien, Katherina
Van Haren, Robert M.
Namias, Nicholas
Blackbourne, Lorne H.
Schulman, Carl I.
TI An analysis of prehospital deaths: Who can we save?
SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY
LA English
DT Article
DE Death; wounds and injuries; emergency medical services; trauma
ID OPERATION-IRAQI-FREEDOM; COMBAT CASUALTY CARE; MAJOR LIMB TRAUMA;
TOURNIQUET USE; PREVENTABLE DEATH; RURAL STATE; MORTALITY; BATTLEFIELD;
OUTCOMES; INJURY
AB BACKGROUND: Since their inception in the late 1970s, trauma networks have saved thousands of lives in the prehospital setting. However, few recent works have been done to evaluate the patients who die in the field. Understanding the epidemiology of these deaths is crucial for trauma system performance evaluation and improvement. We hypothesized that specific patterns of injury could be identified and targeted for intervention.
METHODS: Medical examiner reports in a large, urban county were reviewed including all trauma deaths during 2011 that were not transported to a hospital (i.e., died at the scene) or dead on arrival. Age, sex, date of death, mechanism, and list of injuries were recorded. An expert panel reviewed each case to determine the primary cause of death, and if the patient's death was caused by potentially survivable injuries or nonsurvivable injuries.
RESULTS: A total of 512 patients were included. Patients were 80% male, died mostly of blunt (53%) and penetrating (46%) causes, and included 21% documented suicides. The leading cause of death was neurotrauma (36%), followed by hemorrhage (34%), asphyxia (15%), and combined neurotrauma/hemorrhage (15%). The anatomic regions most frequently injured were the brain (59%), chest (54%), and abdomen (35%). Finally, 29% of the patient deaths were classified as a result of potentially survivable injuries given current treatment options, mostly from hemorrhage and chest injuries.
CONCLUSION: More than one of every five trauma deaths in our study population had potentially survivable injuries. In this group, chest injuries and death via hemorrhage were predominant and suggest targets for future research and implementation of novel prehospital interventions. In addition, efforts targeting suicide prevention remain of great importance. Copyright (C) 2014 by Lippincott Williams & Wilkins
C1 [Davis, James S.; Satahoo, Shevonne S.; Naranjo, Daniel; Julien, Katherina; Van Haren, Robert M.; Namias, Nicholas; Schulman, Carl I.] Univ Miami, Miller Sch Med, DeWitt Daughtry Dept Surg, Jackson Mem Hosp, Miami, FL 33101 USA.
[Butler, Frank K.] Joint Trauma Syst San Antonio, Comm Tact Combat Casualty Care & Prehosp Trauma C, San Antonio, TX USA.
[Blackbourne, Lorne H.] Brooke Army Med Ctr, Dept Surg, San Antonio, TX USA.
[Butler, Frank K.] Uniformed Serv Univ Hlth Sci, Dept Mil & Emergency Med, Bethesda, MD 20814 USA.
RP Schulman, CI (reprint author), Univ Miami, Miller Sch Med, DeWitt Daughtry Family Dept Surg, POB 016960 D-40, Miami, FL 33101 USA.
EM cschulman@med.miami.edu
NR 33
TC 15
Z9 15
U1 1
U2 5
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 2163-0755
EI 2163-0763
J9 J TRAUMA ACUTE CARE
JI J. Trauma Acute Care Surg.
PD AUG
PY 2014
VL 77
IS 2
BP 213
EP 218
DI 10.1097/TA.0000000000000292
PG 6
WC Critical Care Medicine; Surgery
SC General & Internal Medicine; Surgery
GA AN0EJ
UT WOS:000340255700006
PM 25058244
ER
PT J
AU Dennison, SM
Anasti, KM
Jaeger, FH
Stewart, SM
Pollara, J
Liu, PH
Kunz, EL
Zhang, RJ
Vandergrift, N
Permar, S
Ferrari, G
Tomaras, GD
Bonsignori, M
Michael, NL
Kim, JH
Kaewkungwal, J
Nitayaphan, S
Pitisuttithum, P
Rerks-Ngarm, S
Liao, HX
Haynes, BF
Alam, SM
AF Dennison, S. Moses
Anasti, Kara M.
Jaeger, Frederick H.
Stewart, Shelley M.
Pollara, Justin
Liu, Pinghuang
Kunz, Erika L.
Zhang, Ruijun
Vandergrift, Nathan
Permar, Sallie
Ferrari, Guido
Tomaras, Georgia D.
Bonsignori, Mattia
Michael, Nelson L.
Kim, Jerome H.
Kaewkungwal, Jaranit
Nitayaphan, Sorachai
Pitisuttithum, Punnee
Rerks-Ngarm, Supachai
Liao, Hua-Xin
Haynes, Barton F.
Alam, S. Munir
TI Vaccine-Induced HIV-1 Envelope gp120 Constant Region 1-Specific
Antibodies Expose a CD4-Inducible Epitope and Block the Interaction of
HIV-1 gp140 with Galactosylceramide
SO JOURNAL OF VIROLOGY
LA English
DT Article
ID HUMAN-IMMUNODEFICIENCY-VIRUS; RECOMBINANT GLYCOPROTEIN-120 VACCINE;
NEUTRALIZING HUMAN-ANTIBODY; EFFICACY TRIAL; MONOCLONAL-ANTIBODY;
EPITHELIAL-CELLS; DOUBLE-BLIND; T-CELLS; QUANTITATIVE MEASUREMENTS;
VIROLOGICAL SYNAPSES
AB Mucosal epithelial cell surface galactosylceramide (Galcer) has been postulated to be a receptor for HIV-1 envelope (Env) interactions with mucosal epithelial cells. Disruption of the HIV-1 Env interaction with such alternate receptors could be one strategy to prevent HIV-1 entry through the mucosal barrier. To study antibody modulation of HIV-1 Env-Galcer interactions, we used Galcer-containing liposomes to assess whether natural-and vaccine-induced monoclonal antibodies can block HIV-1 Env binding to Galcer. HIV-1 Env gp140 proteins bound to Galcer liposomes with K(d)s (dissociation constants) in the nanomolar range. Several HIV-1 ALVAC/AIDSVAX vaccinee-derived monoclonal antibodies (MAbs) specific for the gp120 first constant (C1) region blocked Galcer binding of a transmitted/founder HIV-1 Env gp140. Among the C1-specific MAbs that showed Galcer blocking, the antibody-dependent cellular cytotoxicity-mediating CH38 IgG and its natural IgA isotype were the most potent blocking antibodies. C1-specific IgG monoclonal antibodies that blocked Env binding to Galcer induced upregulation of the gp120 CD4-inducible (CD4i) epitope bound by MAb 17B, demonstrating that a conformational change in gp120 may be required for Galcer blocking. However, the MAb 17B itself did not block Env-Galcer binding, suggesting that the C1 antibody-induced gp120 conformational changes resulted in alteration in a Galcer binding site distant from the CD4i 17B MAb binding site.
C1 [Dennison, S. Moses; Anasti, Kara M.; Jaeger, Frederick H.; Stewart, Shelley M.; Liu, Pinghuang; Kunz, Erika L.; Zhang, Ruijun; Vandergrift, Nathan; Permar, Sallie; Ferrari, Guido; Tomaras, Georgia D.; Bonsignori, Mattia; Liao, Hua-Xin; Haynes, Barton F.; Alam, S. Munir] Duke Univ, Sch Med, Duke Human Vaccine Inst, Durham, NC 27708 USA.
[Bonsignori, Mattia; Liao, Hua-Xin; Haynes, Barton F.; Alam, S. Munir] Duke Univ, Sch Med, Dept Med, Durham, NC 27706 USA.
[Permar, Sallie; Tomaras, Georgia D.; Haynes, Barton F.] Duke Univ, Sch Med, Dept Immunol, Durham, NC USA.
[Ferrari, Guido; Tomaras, Georgia D.] Duke Univ, Sch Med, Dept Surg, Durham, NC USA.
[Alam, S. Munir] Duke Univ, Sch Med, Dept Pathol, Durham, NC 27706 USA.
[Permar, Sallie] Duke Univ, Sch Med, Dept Pediat, Durham, NC USA.
[Permar, Sallie; Tomaras, Georgia D.] Duke Univ, Sch Med, Dept Mol Genet & Microbiol, Durham, NC USA.
[Michael, Nelson L.; Kim, Jerome H.] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD USA.
[Kaewkungwal, Jaranit; Pitisuttithum, Punnee] Mahidol Univ, Bangkok 10700, Thailand.
[Nitayaphan, Sorachai] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand.
[Rerks-Ngarm, Supachai] Minist Publ Hlth, Dept Dis Control, Nonthaburi, Thailand.
RP Alam, SM (reprint author), Duke Univ, Sch Med, Duke Human Vaccine Inst, Durham, NC 27708 USA.
EM hayne002@mc.duke.edu; alam0004@mc.duke.edu
RI Ferrari, Guido/A-6088-2015; Tomaras, Georgia/J-5041-2016
FU Bill & Melinda Gates Foundation [OPP1033098, OPP1040758]; Center for
HIV/AIDS Vaccine Immunology (CHAVI) [AI067854]; Center for HIV/AIDS
Vaccine Immunogen Discovery (CHAVI- ID) from the NIH, NIAID
[UM1AI100645- 01]
FX This research was conducted as part of the Collaboration for AIDS
Vaccine Discovery (CAVD) with support from the Bill & Melinda Gates
Foundation to B.F.H. (OPP1033098 and OPP1040758) and from the Center for
HIV/AIDS Vaccine Immunology (CHAVI; AI067854) and the Center for
HIV/AIDS Vaccine Immunogen Discovery (CHAVI- ID; UM1AI100645- 01) from
the NIH, NIAID.
NR 66
TC 3
Z9 3
U1 0
U2 4
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0022-538X
EI 1098-5514
J9 J VIROL
JI J. Virol.
PD AUG
PY 2014
VL 88
IS 16
BP 9406
EP 9417
DI 10.1128/JVI.01031-14
PG 12
WC Virology
SC Virology
GA AM7HP
UT WOS:000340036800056
PM 24920809
ER
PT J
AU Dittmar, EM
Cimprich, DA
Sperry, JH
Weatherhead, PJ
AF Dittmar, Erika M.
Cimprich, David A.
Sperry, Jinelle H.
Weatherhead, Patrick J.
TI Habitat Selection by Juvenile Black-Capped Vireos Following Independence
from Parental Care
SO JOURNAL OF WILDLIFE MANAGEMENT
LA English
DT Article
DE endangered species; habitat use; juvenile movements; juvenile songbirds;
post-breeding; post-fledging; radio-telemetry; riparian; Vireo
atricapilla
ID OVENBIRDS SEIURUS-AUROCAPILLA; TEMPERATE FORESTS; SURVIVAL; RIPARIAN;
VEGETATION; MOVEMENTS; BIRDS; ROBINS; STREAM; COVER
AB If differences in ecological requirements result in juvenile birds using different habitats from breeding birds, then habitat management to protect those birds must protect both breeding and post-breeding habitats. We examined habitat selection by juvenile black-capped vireos (Vireo atricapilla) following their independence from parental care, in 2010-2013 on Fort Hood Military Reservation in central Texas, USA. The black-capped vireo is a federally endangered species that nests almost exclusively in shrub vegetation, but previous anecdotal observations indicate that juveniles may prefer riparian vegetation. We used mist-net capture rates and radio-telemetry to determine relative abundance of juvenile vireos across habitats, to quantify movement patterns and habitat selection, and to investigate how vegetation density and arthropod abundance influenced habitat selection. We captured juveniles at similar rates in shrub and riparian vegetation. Radio telemetry data indicated that juveniles selected riparian vegetation over most other available vegetation types, and tended to stay in riparian vegetation upon arrival. Juveniles selected areas characterized by more canopy cover, denser foliage, and more arthropods. Riparian vegetation provides this combination of features more than other vegetation types, indicating that cover and food are the basis for habitat selection by juveniles. Our results indicate that habitat conservation strategies for black-capped vireos should include protection of riparian vegetation near breeding areas, and more generally, that avian conservation strategies that focus only on breeding areas may potentially overlook other key habitats. (c) 2014 The Wildlife Society.
C1 [Dittmar, Erika M.; Sperry, Jinelle H.; Weatherhead, Patrick J.] Univ Illinois, Dept Nat Resources & Environm Sci, Urbana, IL 61801 USA.
[Cimprich, David A.] Environm Div, Ft Hood, TX 76544 USA.
[Sperry, Jinelle H.] Engineer Res & Dev Ctr, Champaign, IL 61826 USA.
RP Dittmar, EM (reprint author), Univ Illinois, Dept Nat Resources & Environm Sci, W-519 Turner Hall,1102 S Goodwin Ave, Urbana, IL 61801 USA.
EM erikadittmar@yahoo.com
FU Texas Parks and Wildlife Department, Austin, Texas; Student Conservation
Association's Segal AmeriCorps Education Award
FX We thank A. Harless, C. Godwin, C. Rankhorn, C. Wass, G. Palmer, J.
Perez, K. Comolli, M. Chan, M. Heimbuch, M. Singh, P. Cimprich, and R.
Palmer for their assistance in the field. We are also thankful for the
additional support from B. DeGregorio, C. Picinich, D. Kovar, M. Noble,
M. Ward, S. Summers, and T. Hayden. Financial support for this project
was provided by Texas Parks and Wildlife Department, Austin, Texas.
Additional financial support is provided by the Student Conservation
Association's Segal AmeriCorps Education Award. This project was
completed in cooperation with U.S. Army Fort Hood Natural Resources
Branch, The Nature Conservancy, and University of Illinois
Urbana-Champaign. The content of this manuscript does not reflect the
position or policy of the United States government and no official
endorsement should be inferred.
NR 32
TC 2
Z9 2
U1 0
U2 45
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0022-541X
EI 1937-2817
J9 J WILDLIFE MANAGE
JI J. Wildl. Manage.
PD AUG
PY 2014
VL 78
IS 6
BP 1005
EP 1011
DI 10.1002/jwmg.738
PG 7
WC Ecology; Zoology
SC Environmental Sciences & Ecology; Zoology
GA AN0TN
UT WOS:000340297000007
ER
PT J
AU Burgess, E
AF Burgess, Edwin
TI The Real Custer: From Boy General to Tragic Hero
SO LIBRARY JOURNAL
LA English
DT Book Review
C1 [Burgess, Edwin] US Army Combined Arms Res Lib, Ft Leavenworth, KS 66027 USA.
RP Burgess, E (reprint author), US Army Combined Arms Res Lib, Ft Leavenworth, KS 66027 USA.
NR 1
TC 0
Z9 0
U1 0
U2 2
PU REED BUSINESS INFORMATION
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010 USA
SN 0363-0277
J9 LIBR J
JI Libr. J.
PD AUG
PY 2014
VL 139
IS 13
BP 108
EP 108
PG 1
WC Information Science & Library Science
SC Information Science & Library Science
GA AM7DM
UT WOS:000340024900236
ER
PT J
AU Burgess, E
AF Burgess, Edwin
TI Soldier Girls: The Battles of Three Women at Home and at War
SO LIBRARY JOURNAL
LA English
DT Book Review
C1 [Burgess, Edwin] US Army Combined Arms Res Lib, Ft Leavenworth, KS 66027 USA.
RP Burgess, E (reprint author), US Army Combined Arms Res Lib, Ft Leavenworth, KS 66027 USA.
NR 1
TC 0
Z9 0
U1 0
U2 1
PU REED BUSINESS INFORMATION
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010 USA
SN 0363-0277
J9 LIBR J
JI Libr. J.
PD AUG
PY 2014
VL 139
IS 13
BP 113
EP 113
PG 1
WC Information Science & Library Science
SC Information Science & Library Science
GA AM7DM
UT WOS:000340024900262
ER
PT J
AU Herrell, RK
Edens, EN
Riviere, LA
Thomas, JL
Bliese, PD
Hoge, CW
AF Herrell, Richard K.
Edens, Edward N.
Riviere, Lyndon A.
Thomas, Jeffrey L.
Bliese, Paul D.
Hoge, Charles W.
TI Assessing Functional Impairment in a Working Military Population: The
Walter Reed Functional Impairment Scale
SO PSYCHOLOGICAL SERVICES
LA English
DT Article
DE functional impairment; military; scale; validation; Land Combat Study
ID POSTTRAUMATIC-STRESS-DISORDER; TRAUMATIC BRAIN-INJURY; MENTAL-HEALTH
PROBLEMS; PRIMARY-CARE; SOMATIC SYMPTOMS; PHYSICAL HEALTH; WAR VETERANS;
IRAQ WAR; COMBAT; ASSOCIATION
AB Measurement of functional impairment is a priority for the military and other professional work groups routinely exposed to stressful traumatic events as part of their occupation. Standard measures of impairment used in general or chronically ill populations contain many items not suitable for these populations, and include mental health symptoms items that are not true measures of functioning. We created a new, 14-item scale-the Walter Reed Functional Impairment Scale-to assess functioning in 4 domains (physical, occupational, social, and personal). We asked 3,380 soldiers how much difficulty they currently have in each of the 4 domains on a 5-point scale. Behaviorally based psychosocial and occupational performance measures and general health questions were used to validate the scale. The utility of the scale was assessed against clinical measures of psychopathology and physical health (depression, posttraumatic stress disorder [PTSD], general health, generalized physical symptoms). We utilized Cronbach's alpha, item response theory, and the score test for trend to establish consistency of items and the validity of the scale. The scale exhibited excellent reliability (Cronbach's alpha = 0.92) and validity. The individual items and quartiles of sum scores were strongly correlated with negative occupational and social performance, and the utility of the scale was demonstrated by strong correlations with depression, PTSD, and high levels of generalized physical symptoms. This scale exhibits excellent psychometric properties in this sample of U. S. soldiers and, pending future research, is likely to have utility for other healthy occupational groups.
C1 [Herrell, Richard K.; Riviere, Lyndon A.; Bliese, Paul D.; Hoge, Charles W.] Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci, Silver Spring, MD 20910 USA.
[Edens, Edward N.] US Army Training & Doctrine Command, Ft Eustis, VA USA.
[Thomas, Jeffrey L.] US Army Med Res Unit Europe, Walter Reed Army Inst Res, Sembach, Germany.
RP Herrell, RK (reprint author), Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci, Mil Psychiat Branch, Silver Spring, MD 20910 USA.
EM richard.k.herrell.ctr@mail.mil
NR 43
TC 3
Z9 3
U1 3
U2 13
PU AMER PSYCHOLOGICAL ASSOC
PI WASHINGTON
PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA
SN 1541-1559
EI 1939-148X
J9 PSYCHOL SERV
JI Psychol. Serv.
PD AUG
PY 2014
VL 11
IS 3
BP 254
EP 264
DI 10.1037/a0037347
PG 11
WC Psychology, Clinical
SC Psychology
GA AN0SS
UT WOS:000340294900002
PM 25068298
ER
PT J
AU Russell, DW
Whalen, RJ
Riviere, LA
Clarke-Walper, K
Bliese, PD
Keller, DD
Pangelian, SI
Thomas, JL
AF Russell, Dale W.
Whalen, Ronald J.
Riviere, Lyndon A.
Clarke-Walper, Kristina
Bliese, Paul D.
Keller, Darc D.
Pangelian, Susan I.
Thomas, Jeffrey L.
TI Embedded Behavioral Health Providers: An Assessment With the Army
National Guard
SO PSYCHOLOGICAL SERVICES
LA English
DT Article
DE Army; behavioral health; embedded provider; National Guard; unit climate
ID MENTAL-HEALTH; ACTIVE-DUTY; COMBAT; BARRIERS; CARE; SOLDIERS; STIGMA;
IRAQ; PREVALENCE; MULTILEVEL
AB Although the Army has recently begun the practice of embedding behavioral health care providers (EBHP) in units in an effort to improve soldier well-being, the efficacy of this practice has not been evaluated. This study assesses 1 of the first programs implemented by the military. Using cross-sectional data obtained from a confidential survey of 12 company-level units in the California Army National Guard (n = 1,132), this study examines differences between units with and without EBHPs across a number of measures. Multilevel analysis of behavioral health symptoms, unit climate, perceptions of stigma, and practical barriers to care failed to detect main effects between units with EBHPs relative to those without. However, cross-level interactions were detected between unit EBHP status and soldiers reporting close relationship (e.g., spouse, girlfriend/boyfriend) impairment. Exploratory findings suggest that, among soldiers reporting close relationship impairment, those belonging to units with EBHPs reported significantly lower behavioral health symptoms and significantly more positive unit climates. Based on these limited exploratory finings, this study suggests that EBHPs in reserve units may have a positive effect on a subset of soldiers (i.e., those reporting close relationship impairment). More assessments of embed programs should be conducted, particularly using prospective longitudinal data among randomized units.
C1 [Russell, Dale W.] Uniformed Serv Univ Hlth Sci, F Edward Hebert Sch Med, Dept Psychiat, Bethesda, MD 20814 USA.
[Russell, Dale W.; Whalen, Ronald J.; Riviere, Lyndon A.; Clarke-Walper, Kristina; Bliese, Paul D.] Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci, Silver Spring, MD 20910 USA.
[Keller, Darc D.; Pangelian, Susan I.] Calif Natl Guard, Sacramento, CA USA.
[Thomas, Jeffrey L.] US Army Med Res Unit Europe, Heidelberg, Germany.
RP Russell, DW (reprint author), Walter Reed Army Inst Res, 530 Robert Grant Ave, Silver Spring, MD 20910 USA.
EM dale.w.russell1.mil@mail.mil
NR 37
TC 3
Z9 3
U1 0
U2 2
PU AMER PSYCHOLOGICAL ASSOC
PI WASHINGTON
PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA
SN 1541-1559
EI 1939-148X
J9 PSYCHOL SERV
JI Psychol. Serv.
PD AUG
PY 2014
VL 11
IS 3
BP 265
EP 272
DI 10.1037/a0037005
PG 8
WC Psychology, Clinical
SC Psychology
GA AN0SS
UT WOS:000340294900003
PM 24841511
ER
PT J
AU Kalish, VB
Gillham, JE
Unwin, BK
AF Kalish, Virginia B.
Gillham, Joseph E.
Unwin, Brian K.
TI Delirium in Older Persons: Evaluation and Management
SO AMERICAN FAMILY PHYSICIAN
LA English
DT Article
ID RANDOMIZED CONTROLLED-TRIAL; TERMINALLY-ILL PATIENTS; PREVENTING
DELIRIUM; ELDERLY-PATIENTS; RISK-FACTORS; HALOPERIDOL PROPHYLAXIS;
DECREASES DELIRIUM; FUNCTIONAL DECLINE; NONCARDIAC SURGERY; MORTALITY
AB Delirium is defined as an acute, fluctuating syndrome of altered attention, awareness, and cognition. It is common in older persons in the hospital and long-term care facilities and may indicate a life-threatening condition. Assessment for and prevention of delirium should occur at admission and continue throughout a hospital stay. Caregivers should be educated on preventive measures, as well as signs and symptoms of delirium and conditions that would indicate the need for immediate evaluation. Certain medications, sensory impairments, cognitive impairment, and various medical conditions are a few of the risk factors associated with delirium. Preventive interventions such as frequent reorientation, early and recurrent mobilization, pain management, adequate nutrition and hydration, reducing sensory impairments, and ensuring proper sleep patterns have all been shown to reduce the incidence of delirium, regardless of the care environment. Treatment of delirium should focus on identifying and managing the causative medical conditions, providing supportive care, preventing complications, and reinforcing preventive interventions. Pharmacologic interventions should be reserved for patients who are a threat to their own safety or the safety of others and those patients nearing death. In older persons, delirium increases the risk of functional decline, institutionalization, and death. Copyright (C) 2014 American Academy of Family Physicians
C1 [Kalish, Virginia B.] Natl Capitol Consortium, Ft Belvoir, VA 22060 USA.
[Gillham, Joseph E.] Robinson Hlth Clin, Ft Bragg, NC USA.
[Unwin, Brian K.] Caril Clin, Roanoke, VA USA.
RP Kalish, VB (reprint author), Natl Capitol Consortium, 9300 Dewitt Loop, Ft Belvoir, VA 22060 USA.
EM virginia.b.kalish.civ@health.mil
NR 49
TC 7
Z9 8
U1 1
U2 18
PU AMER ACAD FAMILY PHYSICIANS
PI KANSAS CITY
PA 8880 WARD PARKWAY, KANSAS CITY, MO 64114-2797 USA
SN 0002-838X
EI 1532-0650
J9 AM FAM PHYSICIAN
JI Am. Fam. Physician
PD AUG 1
PY 2014
VL 90
IS 3
BP 150
EP 158
PG 9
WC Primary Health Care; Medicine, General & Internal
SC General & Internal Medicine
GA AM6PU
UT WOS:000339987900003
PM 25077720
ER
PT J
AU Kuchuloria, T
Imnadze, P
Chokheli, M
Tsertsvadze, T
Endeladze, M
Mshvidobadze, K
Clark, DV
Bautista, CT
Fadeel, MA
Pimentel, G
House, B
Hepburn, MJ
Wolfel, S
Wolfel, R
Rivard, RG
AF Kuchuloria, Tinatin
Imnadze, Paata
Chokheli, Maiko
Tsertsvadze, Tengiz
Endeladze, Marina
Mshvidobadze, Ketevan
Clark, Danielle V.
Bautista, Christian T.
Fadeel, Moustafa Abdel
Pimentel, Guillermo
House, Brent
Hepburn, Matthew J.
Woelfel, Silke
Woelfel, Roman
Rivard, Robert G.
TI Short Report: Viral Hemorrhagic Fever Cases in the Country of Georgia:
Acute Febrile Illness Surveillance Study Results
SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
LA English
DT Article
ID HANTAVIRUS
AB Minimal information is available on the incidence of Crimean-Congo hemorrhagic fever (CCHF) virus and hantavirus infections in Georgia. From 2008 to 2011, 537 patients with fever >= 38 degrees C for >= 48 hours without a diagnosis were enrolled into a sentinel surveillance study to investigate the incidence of nine pathogens, including CCHF virus and hantavirus. Of 14 patients with a hemorrhagic fever syndrome, 3 patients tested positive for CCHF virus immunoglobulin M (IgM) antibodies. Two of the patients enrolled in the study had acute renal failure. These 2 of 537 enrolled patients were the only patients in the study positive for hantavirus IgM antibodies. These results suggest that CCHF virus and hantavirus are contributing causes of acute febrile syndromes of infectious origin in Georgia. These findings support introduction of critical diagnostic approaches and confirm the need for additional surveillance in Georgia.
C1 [Kuchuloria, Tinatin; Imnadze, Paata; Tsertsvadze, Tengiz] I Javakhishvili Tbilisi State Univ, GE-0179 Tbilisi, Rep of Georgia.
[Imnadze, Paata; Chokheli, Maiko] Natl Ctr Dis Control & Publ Hlth, Tbilisi, Rep of Georgia.
[Tsertsvadze, Tengiz; Endeladze, Marina; Mshvidobadze, Ketevan] Infect Dis AIDS & Clin Immunol Res Ctr, Tbilisi, Rep of Georgia.
[Clark, Danielle V.; Bautista, Christian T.] Walter Reed Army Inst Res, Silver Spring, MD USA.
[Fadeel, Moustafa Abdel; Pimentel, Guillermo; House, Brent] US Naval Med Res Unit 3, Global Dis Detect & Response Program, Cairo, Egypt.
US Army Med Command, San Antonio, TX USA.
[Woelfel, Silke; Woelfel, Roman] Bundeswehr Inst Microbiol, Munich, Germany.
US Army Med Res Inst Infect Dis, Ft Detrick, MD USA.
RP Kuchuloria, T (reprint author), I Javakhishvili Tbilisi State Univ, 1 Chavchavadze Ave, GE-0179 Tbilisi, Rep of Georgia.
EM drkuchuloria@yahoo.com; pimnadze@ncdc.ge; chokhelimaiko@yahoo.com;
aids@gol.ge; marinaendeladze@ymail.com; katemshvidobadze@yahoo.com;
dvclark@gmail.com; Christian.Bautista@us.army.mil;
Moustafa.AbdelFadeel.eg@med.navy.mil; gpiment@gmail.com;
Brent.House@med.navy.mil; matthew.hepburn@yahoo.com;
silkewoelfel@bundeswehr.org; romanwoelfel@bundeswehr.org;
robert.g.rivard.mil@mail.mil
FU US Department of Defense Global Emerging Infections Surveillance (GEIS)
Program; Medical Biodefense Research Program of the Bundeswehr Joint
Medical Service; US Department of Defense Threat Reduction Agency
FX This work was funded by the US Department of Defense Global Emerging
Infections Surveillance (GEIS) Program and the Medical Biodefense
Research Program of the Bundeswehr Joint Medical Service, and it was
supported by the US Department of Defense Threat Reduction Agency.
NR 12
TC 5
Z9 5
U1 0
U2 1
PU AMER SOC TROP MED & HYGIENE
PI MCLEAN
PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA
SN 0002-9637
EI 1476-1645
J9 AM J TROP MED HYG
JI Am. J. Trop. Med. Hyg.
PD AUG
PY 2014
VL 91
IS 2
BP 246
EP 248
DI 10.4269/ajtmh.13-0460
PG 3
WC Public, Environmental & Occupational Health; Tropical Medicine
SC Public, Environmental & Occupational Health; Tropical Medicine
GA AM4ZD
UT WOS:000339863800009
PM 24891463
ER
PT J
AU Harte, CB
Proctor, SP
Vasterling, JJ
AF Harte, Christopher B.
Proctor, Susan P.
Vasterling, Jennifer J.
TI Prospective Examination of Cigarette Smoking Among Iraq-Deployed and
Nondeployed Soldiers: Prevalence and Predictive Characteristics
SO ANNALS OF BEHAVIORAL MEDICINE
LA English
DT Article
DE Cigarette smoking; Predictors; Military; Operation Iraqi Freedom;
Deployment; Longitudinal
ID UK ARMED-FORCES; TOBACCO USE; POSTTRAUMATIC-STRESS; NICOTINE DEPENDENCE;
PROSPECTIVE COHORT; MILITARY DEPLOYMENT; COMBAT EXPOSURES;
UNITED-STATES; WAR VETERANS; RISK-FACTORS
AB Identifying characteristics that influence smoking behavior among military personnel is critical to protect health and operational functioning.
This study prospectively examined rates of cigarette smoking and predictors of changes in smoking behavior as a function of Iraq deployment.
One thousand eighty-two US Army soldiers (n = 773 Iraq-deployed; n = 309 nondeployed) completed assessments at two sessions [time 1: April 2003-July 2004; time 2: May 2004-July 2004 (nondeployers); January 2005-September 2006 (deployers)].
Approximately 48 % of participants smoked at both time points, with 6 % initiating smoking and 6 % quitting. Smoking initiation was associated with warzone stress exposure; female gender and high military unit support predicted cessation. Military rank and alcohol use were associated with both smoking initiation and cessation.
Findings highlight the potential benefits of targeting risk factors for cigarette smoking in comprehensive military health programs aimed at smoking prevention and cessation.
C1 [Harte, Christopher B.; Proctor, Susan P.] VA Boston Healthcare Syst, Psychol Serv, Boston, MA 02130 USA.
[Harte, Christopher B.; Vasterling, Jennifer J.] Boston Univ, Sch Med, Dept Psychiat, Boston, MA 02118 USA.
[Proctor, Susan P.] US Army Res Inst Environm Med, Mil Performance Div, Natick, MA USA.
[Vasterling, Jennifer J.] VA Boston Healthcare Syst, Psychol Serv, Boston, MA 02130 USA.
[Vasterling, Jennifer J.] VA Boston Healthcare Syst, VA Natl Ctr PTSD, Boston, MA 02130 USA.
RP Vasterling, JJ (reprint author), VA Boston Healthcare Syst, Psychol Serv, 150 S Huntington Ave 116B, Boston, MA 02130 USA.
EM jennifer.vasterling@va.gov
OI Harte, Christopher/0000-0002-8097-7369
NR 61
TC 3
Z9 3
U1 1
U2 10
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0883-6612
EI 1532-4796
J9 ANN BEHAV MED
JI Ann. Behav. Med.
PD AUG
PY 2014
VL 48
IS 1
BP 38
EP 49
DI 10.1007/s12160-013-9584-5
PG 12
WC Psychology, Multidisciplinary
SC Psychology
GA AM3DE
UT WOS:000339731400007
PM 24474618
ER
PT J
AU Valenzuela, A
Munson, C
Porwitzky, A
Weidman, M
Richardson, M
AF Valenzuela, Anthony
Munson, Chase
Porwitzky, Andrew
Weidman, Matthew
Richardson, Martin
TI Comparison between geometrically focused pulses versus filaments in
femtosecond laser ablation of steel and titanium alloys
SO APPLIED PHYSICS B-LASERS AND OPTICS
LA English
DT Article
ID INDUCED BREAKDOWN SPECTROSCOPY; MULTIPLE FILAMENTATION; TRANSPARENT
MEDIA; AIR; LIBS; PROPAGATION; LIGHT; POWER; TI
AB Kerr self-focusing of high-power ultrashort laser pulses in atmosphere may result in a structure or structures of high intensity that can propagate over long distances with little divergence. Filamentation has garnered significant interest in the nonlinear optics community due to its unique properties. Salient features of filaments include a central region of intense laser power (greater than the ionization threshold of the propagation medium) and a low temperature plasma column that lasts up to nanoseconds in duration after the passage of the laser pulse. Steel and titanium samples are ablated by filaments and by sharply focused sub-picosecond laser pulses. We then performed metrology on the samples to compare the ablation features in addition to modeling of the plasma ablation process. Ablation with filaments leads to a wider range of material responses as compared to ablation with sharply focused pulse. This results in potential complications for applications of filament ablation that depends on the rate of material removal and spectroscopic analysis.
C1 [Valenzuela, Anthony; Munson, Chase; Porwitzky, Andrew] US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA.
[Weidman, Matthew; Richardson, Martin] Univ Cent Florida, Coll Opt & Photon, Townes Laser Inst, Orlando, FL 32816 USA.
[Weidman, Matthew; Richardson, Martin] Univ Cent Florida, Coll Opt & Photon, CREOL, Orlando, FL 32816 USA.
RP Valenzuela, A (reprint author), US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA.
EM anthony.r.valenzuela6.civ@mail.mil
FU U.S. Army Research Laboratory; University of Central Florida under the
JTO/AFOSR MRI [FA95501110001]; State of Florida
FX The authors express their gratitude for the assistance at the U.S. Army
Research Laboratory from Jeffrey Ball; Robert Borys, Jr.; Frank De
Lucia, Jr.; Jennifer Gottfried; Gregory Gentle; and David MacKenzie. The
authors also express their gratitude to Casey Boutwell, Ming Wei, and
Matthieu Baudelet at the University of Central Florida. The authors also
would like to acknowledge funding from the U.S. Army Research Laboratory
and research at the University of Central Florida is funded under the
JTO/AFOSR MRI on "Fundamentals of Filament Interaction" number
FA95501110001 and The State of Florida.
NR 32
TC 4
Z9 4
U1 2
U2 34
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0946-2171
EI 1432-0649
J9 APPL PHYS B-LASERS O
JI Appl. Phys. B-Lasers Opt.
PD AUG
PY 2014
VL 116
IS 2
BP 485
EP 491
DI 10.1007/s00340-013-5724-7
PG 7
WC Optics; Physics, Applied
SC Optics; Physics
GA AM3BR
UT WOS:000339727000027
ER
PT J
AU Williams, SG
Collen, J
Wickwire, E
Lettieri, CJ
Mysliwiec, V
AF Williams, Scott G.
Collen, Jacob
Wickwire, Emerson
Lettieri, Christopher J.
Mysliwiec, Vincent
TI The Impact of Sleep on Soldier Performance
SO CURRENT PSYCHIATRY REPORTS
LA English
DT Article
DE Sleep deprivation; Combat related sleep disorder; Insomnia; Obstructive
sleep apnea; Sleep disordered breathing; Posttraumatic stress disorder;
Nightmares
ID POSTTRAUMATIC-STRESS-DISORDER; RANDOMIZED CONTROLLED-TRIAL; TRAUMATIC
BRAIN-INJURY; RESTLESS LEGS SYNDROME; COGNITIVE-BEHAVIORAL THERAPY;
QUALITY-OF-LIFE; STATES-MILITARY-ACADEMY; SHIFT WORK DISORDER;
GENERAL-POPULATION; UNITED-STATES
AB The military population is particularly vulnerable to a multitude of sleep-related disorders owing to the type of work performed by active duty servicemembers (ADSMs). Inadequate sleep, due to insufficient quantity or quality, is increasingly recognized as a public health concern. Traditionally, ADSMs have been encouraged that they can adapt to insufficient sleep just as the body adapts to physical training, but there is a substantial body of scientific literature which argues that this is not possible. Additionally, the military work environment creates unique challenges with respect to treatment options for common sleep disorders like obstructive sleep apnea, restless legs syndrome, and parasomnias. This review highlights sleep disorders which are prevalent in the modern military force and discusses the impact of poor sleep on overall performance. Medical treatments and recommendations for unit leaders are also discussed.
C1 [Williams, Scott G.] Womack Army Med Ctr, Ft Bragg, NC USA.
[Williams, Scott G.; Collen, Jacob; Lettieri, Christopher J.] Uniformed Serv Univ Hlth Sci, Dept Med, Bethesda, MD 20814 USA.
[Collen, Jacob] San Antonio Mil Med Ctr, Ft Sam Houston, TX USA.
[Wickwire, Emerson] Howard Cty Ctr Lung & Sleep Med, Columbia, MD USA.
[Wickwire, Emerson] Johns Hopkins Sch Med, Dept Psychiat & Behav Sci, Baltimore, MD USA.
[Lettieri, Christopher J.] Walter Reed Natl Mil Med Ctr, Bethesda, MD USA.
[Mysliwiec, Vincent] Madigan Army Med Ctr, Joint Base Lewis McChord, Tacoma, WA 98431 USA.
RP Williams, SG (reprint author), Uniformed Serv Univ Hlth Sci, Dept Med, Room A3060, Bethesda, MD 20814 USA.
EM scott.g.williams@us.army.mil
NR 117
TC 1
Z9 1
U1 1
U2 9
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1523-3812
EI 1535-1645
J9 CURR PSYCHIAT REP
JI Curr. Psychiatry Rep.
PD AUG
PY 2014
VL 16
IS 8
AR 459
DI 10.1007/s11920-014-0459-7
PG 13
WC Psychiatry
SC Psychiatry
GA AM4CX
UT WOS:000339801200003
PM 24942599
ER
PT J
AU Mernild, SH
Liston, GE
Hiemstra, CA
AF Mernild, Sebastian H.
Liston, Glen E.
Hiemstra, Christopher A.
TI Northern Hemisphere Glacier and Ice Cap Surface Mass Balance and
Contribution to Sea Level Rise
SO JOURNAL OF CLIMATE
LA English
DT Article
ID SYNOPTICALLY FORCED HYDROCLIMATOLOGY; GENERAL-CIRCULATION MODELS;
COMPLEX SNOW DISTRIBUTIONS; MAJOR ARCTIC WATERSHEDS; AMMASSALIK ISLAND;
MITTIVAKKAT GLACIER; SOUTHEAST GREENLAND; AIR-TEMPERATURE;
PRECIPITATION; CLIMATE
AB Mass changes and mass contribution to sea level rise from glaciers and ice caps (GIC) are key components of the earth's changing sea level. GIC surface mass balance (SMB) magnitudes and individual and regional mean conditions and trends (1979-2009) were simulated for all GIC having areas greater or equal to 0.5 km(2) in the Northern Hemisphere north of 25 degrees N latitude (excluding the Greenland Ice Sheet). Recent datasets, including the Randolph Glacier Inventory (RGI; v. 2.0), the NOAA Global Land One-km Base Elevation Project (GLOBE), and the NASA Modern-Era Retrospective Analysis for Research and Applications (MERRA) products, together with recent SnowModel developments, allowed relatively high-resolution (1-km horizontal grid; 3-h time step) simulations of GIC surface air temperature, precipitation, sublimation, evaporation, surface runoff, and SMB. Simulated SMB outputs were calibrated against 1422 direct glaciological annual SMB observations of 78 GIC. The overall GIC mean annual and mean summer air temperature, runoff, and SMB loss increased during the simulation period. The cumulative GIC SMB was negative for all regions. The SMB contribution to sea level rise was largest from Alaska and smallest from the Caucasus. On average, the contribution to sea level rise was 0.51 +/- 0.16 mm sea level equivalent (SLE) yr(-1) for 1979-2009 and similar to 40% higher 0.71 +/- 0.15 mm SLE yr(-1) for the last decade, 1999-2009.
C1 [Mernild, Sebastian H.] Los Alamos Natl Lab, Climate Ocean & Sea Ice Modeling Grp, Los Alamos, NM USA.
[Mernild, Sebastian H.] Ctr Sci Studies, Glaciol & Climate Change Lab, Valdivia 5110466, Chile.
[Liston, Glen E.] Colorado State Univ, Cooperat Inst Res Atmosphere, Ft Collins, CO 80523 USA.
[Hiemstra, Christopher A.] US Army Cold Reg Res & Engn Lab, Ft Wainwright, AK USA.
RP Mernild, SH (reprint author), Ctr Sci Studies, Glaciol & Climate Change Lab, Valdivia 5110466, Chile.
EM smernild@gmail.com
FU Earth System Modeling program within the U.S. Department of Energy's
Office of Science; Scientific Discovery for Advanced Computing (SciDAC)
program within the U.S. Department of Energy's Office of Science;
National Nuclear Security Administration of the U.S. Department of
Energy [DE-AC52-06NA25396]; European Community [262693]
FX This work was supported in part by the Earth System Modeling program and
by the Scientific Discovery for Advanced Computing (SciDAC) program
within the U.S. Department of Energy's Office of Science, and by a Los
Alamos National Laboratory (LANL) (LANL is operated under the auspices
of the National Nuclear Security Administration of the U.S. Department
of Energy under Contract DE-AC52-06NA25396). Additional support was
provided from the European Community's Seventh Framework Programme under
Grant Agreement 262693. We thank the NASA Goddard Earth Sciences (GES)
Data and Information Services Center (DISC) and Global Modeling and
Assimilation Office (GMAO) for providing the MERRA datasets, and NOAA
for providing the Global Land One-km Base Elevation Project (GLOBE)
digital elevation model. Request of data should be addressed to the
first author.
NR 82
TC 7
Z9 7
U1 2
U2 37
PU AMER METEOROLOGICAL SOC
PI BOSTON
PA 45 BEACON ST, BOSTON, MA 02108-3693 USA
SN 0894-8755
EI 1520-0442
J9 J CLIMATE
JI J. Clim.
PD AUG 1
PY 2014
VL 27
IS 15
BP 6051
EP 6073
DI 10.1175/JCLI-D-13-00669.1
PG 23
WC Meteorology & Atmospheric Sciences
SC Meteorology & Atmospheric Sciences
GA AM2SY
UT WOS:000339702300022
ER
PT J
AU Lin, YH
Hanson, JA
Strandjord, SE
Salem, NM
Dretsch, MN
Haub, MD
Hibbeln, JR
AF Lin, Yu Hong
Hanson, Jennifer A.
Strandjord, Sarah E.
Salem, Nicholas M.
Dretsch, Michael N.
Haub, Mark D.
Hibbeln, Joseph R.
TI Fast Transmethylation of Total Lipids in Dried Blood by Microwave
Irradiation and its Application to a Population Study
SO LIPIDS
LA English
DT Article
DE Finger pricked blood; Filter paper; Dried blood spot; Microwave reaction
system; PUFA; Omega-3; Omega-6
ID POLYUNSATURATED FATTY-ACIDS; GAS-CHROMATOGRAPHY; MASS-SPECTROMETRY;
FINGERTIP; SUPPLEMENTATION; DROP; OMEGA-3-FATTY-ACIDS;
TRANSESTERIFICATION; PEROXIDATION; VALIDATION
AB A methodology combining finger-pricked blood sampling, microwave accelerated fatty acid assay, fast gas chromatography data acquisition, and automated data processing was developed, evaluated and applied to a population study. Finger-pricked blood was collected on filter paper previously impregnated with 0.05 mg of the antioxidant butylated hydroxytoluene and air-dried at room temperature. Transmethylation was accelerated by microwave irradiation in an explosion-proof multimode microwave reaction system. The chemical procedure was based on a one-step direct transmethylation procedure catalyzed by acetyl chloride. The short-term stability of PUFA in blood dried on filter paper and storage at room temperature was examined using venous blood. The recoveries ranged from 97 to 101 % for the categorized fatty acids as well as the ratios of n-6 to n-3 PUFA and the n-3 % highly unsaturated fatty acid. Specifically, recoveries were 99, 98, 97, and 97 % for linoleic acid (18:2n-6), arachidonic acid (ARA), alpha-linolenic acid (ALA), and docosahexaenoic acid (DHA), respectively. The mol% (mean +/- A SD, 95 % confidence interval) of fatty acid composition in subjects from the population study was determined as 36.2 +/- A 3.8 (35.8, 36.7), 23.2 +/- A 3.0 (22.8, 23.5), 36.8 +/- A 3.5 (36.4, 37.2) and 3.79 +/- A 1.0 (3.68, 3.91) for the saturated, monounsaturated, n-6 and n-3 PUFA, respectively. Individually, the mean mol% (95 % CI) was 22.6 (22.3, 22.9) for 18:2n-6, 9.5 (9.3, 9.7) for ARA, 0.51 (0.49, 0.53) for ALA, 0.42 (0.38, 0.47) for eicosapentaenoic acid (EPA), and 1.67 (1.61, 1.73) for DHA. This methodology provides an accelerated yet high-efficiency, chemically safe, and temperature-controlled transmethylation, with diverse laboratory applications including population studies.
C1 [Lin, Yu Hong; Strandjord, Sarah E.; Salem, Nicholas M.; Hibbeln, Joseph R.] NIAAA, Lab Membrane Biochem & Biophys, NIH, Bethesda, MD 20892 USA.
[Hanson, Jennifer A.] Louisiana Tech Univ, Sch Human Ecol, Ruston, LA 71270 USA.
[Hanson, Jennifer A.] Kansas State Univ, Dept Hospitality Management & Dietet, Manhattan, KS 66506 USA.
[Dretsch, Michael N.] Walter Reed Natl Mil Med Ctr, Natl Intrepid Ctr Excellence, Bethesda, MD USA.
[Dretsch, Michael N.] US Army Aeromed Res Lab, Ft Rucker, AL USA.
[Haub, Mark D.] Kansas State Univ, Dept Human Nutr, Manhattan, KS 66506 USA.
RP Lin, YH (reprint author), NIAAA, Lab Membrane Biochem & Biophys, NIH, Bethesda, MD 20892 USA.
EM yulin@mail.nih.gov
OI Hanson, Jennifer /0000-0003-0437-6489
FU National Institute on Alcohol Abuse and Alcoholism, National Institutes
of Health
FX The authors wish to acknowledge the service members who took part in the
study as well as Dr. Norman Salem Jr. and Dr. Charlie N. Serhan for the
valuable advice and discussion on the method development. The authors
thank Mr. Brian Brown, NIH Library Writing Center, for manuscript
editing assistance. This project was partially funded by the Intramural
Research Program of the National Institute on Alcohol Abuse and
Alcoholism, National Institutes of Health.
NR 42
TC 7
Z9 7
U1 2
U2 8
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 0024-4201
EI 1558-9307
J9 LIPIDS
JI Lipids
PD AUG
PY 2014
VL 49
IS 8
BP 839
EP 851
DI 10.1007/s11745-014-3918-3
PG 13
WC Biochemistry & Molecular Biology; Nutrition & Dietetics
SC Biochemistry & Molecular Biology; Nutrition & Dietetics
GA AM4NP
UT WOS:000339831800010
PM 24986160
ER
PT J
AU Zhang, L
Hu, XZ
Benedek, DM
Fullerton, CS
Forsten, RD
Naifeh, JA
Li, X
Li, H
Benevides, KN
Smerin, S
Le, T
Choi, K
Ursano, RJ
AF Zhang, L.
Hu, X-Z
Benedek, D. M.
Fullerton, C. S.
Forsten, R. D.
Naifeh, J. A.
Li, X.
Li, H.
Benevides, K. N.
Smerin, S.
Le, T.
Choi, K.
Ursano, R. J.
TI The interaction between stressful life events and leukocyte telomere
length is associated with PTSD
SO MOLECULAR PSYCHIATRY
LA English
DT Letter
ID CARDIOVASCULAR-DISEASE; CHECKLIST
C1 [Zhang, L.; Hu, X-Z; Benedek, D. M.; Fullerton, C. S.; Naifeh, J. A.; Li, X.; Li, H.; Benevides, K. N.; Smerin, S.; Le, T.; Choi, K.; Ursano, R. J.] Uniformed Serv Univ Hlth Sci, Dept Psychiat, Ctr Study Traumat Stress, Bethesda, MD 20814 USA.
[Forsten, R. D.] US Army Special Operat Command, Ft Bragg, NC USA.
RP Zhang, L (reprint author), Uniformed Serv Univ Hlth Sci, Dept Psychiat, Ctr Study Traumat Stress, Bethesda, MD 20814 USA.
EM Lezhang@USUHS.mil
NR 10
TC 18
Z9 18
U1 0
U2 6
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1359-4184
EI 1476-5578
J9 MOL PSYCHIATR
JI Mol. Psychiatr.
PD AUG
PY 2014
VL 19
IS 8
BP 855
EP 856
DI 10.1038/mp.2013.141
PG 3
WC Biochemistry & Molecular Biology; Neurosciences; Psychiatry
SC Biochemistry & Molecular Biology; Neurosciences & Neurology; Psychiatry
GA AM7IR
UT WOS:000340040200003
PM 24189343
ER
PT J
AU Hoge, CW
Grossman, SH
Auchterlonie, JL
Riviere, LA
Milliken, CS
Wilk, JE
AF Hoge, Charles W.
Grossman, Sasha H.
Auchterlonie, Jennifer L.
Riviere, Lyndon A.
Milliken, Charles S.
Wilk, Joshua E.
TI PTSD Treatment for Soldiers After Combat Deployment: Low Utilization of
Mental Health Care and Reasons for Dropout
SO PSYCHIATRIC SERVICES
LA English
DT Article
ID POSTTRAUMATIC-STRESS-DISORDER; NATIONAL-GUARD SOLDIERS; ADMINISTRATIVE
DATA; UNITED-STATES; VETERANS; IRAQ; BARRIERS; AFGHANISTAN; PREVALENCE;
STIGMA
AB Objective: Limited data exist on the adequacy of treatment for post-traumatic stress disorder (PTSD) after combat deployment. This study assessed the percentage of soldiers in need of PTSD treatment, the percentage receiving minimally adequate care, and reasons for dropping out of care. Methods: Data came from two sources: a population-based cohort of 45,462 soldiers who completed the Post-Deployment Health Assessment and a cross-sectional survey of 2,420 infantry soldiers after returning from Afghanistan (75% response rate). Results: Of 4,674 cohort soldiers referred to mental health care at a military treatment facility, 75% followed up with this referral. However, of 2,230 soldiers who received a PTSD diagnosis within 90 days of return from Afghanistan, 22% had only one mental health care visit and 41% received minimally adequate care (eight or more encounters in 12 months). Of 229 surveyed soldiers who screened positive for PTSD (PTSD Checklist score 50), 48% reported receiving mental health treatment in the prior six months at any health care facility. Of those receiving treatment, the median number of visits in six months was four; 22% had only one visit, 52% received minimally adequate care (four or more visits in six months), and 24% dropped out of care. Reported reasons for dropout included soldiers feeling they could handle problems on their own, work interference, insufficient time with the mental health professional, stigma, treatment ineffectiveness, confidentiality concerns, or discomfort with how the professional interacted. Conclusions: Treatment reach for PTSD after deployment remains low to moderate, with a high percentage of soldiers not accessing care or not receiving adequate treatment. This study represents a call to action to validate interventions to improve treatment engagement and retention.
C1 [Hoge, Charles W.; Grossman, Sasha H.; Auchterlonie, Jennifer L.; Riviere, Lyndon A.; Milliken, Charles S.; Wilk, Joshua E.] Walter Reed Army Inst Res, Ctr Psychiat & Neurosci, Silver Spring, MD 20910 USA.
RP Hoge, CW (reprint author), Walter Reed Army Inst Res, Ctr Psychiat & Neurosci, Silver Spring, MD 20910 USA.
EM charles.hoge@us.army.mil
FU U.S. Army Military Operational Research Program
FX Funding was received from the U.S. Army Military Operational Research
Program. The authors thank the Land Combat Study team. The views
contained here are those of the authors and are not considered to be an
official position of the U.S. Department of the Army or the Department
of Defense.
NR 37
TC 43
Z9 43
U1 3
U2 24
PU AMER PSYCHIATRIC PUBLISHING, INC
PI ARLINGTON
PA 1000 WILSON BOULEVARD, STE 1825, ARLINGTON, VA 22209-3901 USA
SN 1075-2730
EI 1557-9700
J9 PSYCHIAT SERV
JI Psychiatr. Serv.
PD AUG
PY 2014
VL 65
IS 8
BP 997
EP 1004
DI 10.1176/appi.ps.201300307
PG 8
WC Health Policy & Services; Public, Environmental & Occupational Health;
Psychiatry
SC Health Care Sciences & Services; Public, Environmental & Occupational
Health; Psychiatry
GA AM3TU
UT WOS:000339776500007
PM 24788253
ER
PT J
AU Quidley, AM
Bland, CM
Bookstaver, PB
Kuper, K
AF Quidley, April Miller
Bland, Christopher M.
Bookstaver, P. Brandon
Kuper, Kristi
TI Perioperative management of bariatric surgery patients
SO AMERICAN JOURNAL OF HEALTH-SYSTEM PHARMACY
LA English
DT Review
ID HELICOBACTER-PYLORI INFECTION; GASTRIC BYPASS-SURGERY; SURGICAL-SITE
INFECTION; MORBIDLY OBESE-PATIENTS; MOLECULAR-WEIGHT HEPARIN;
QUALITY-OF-LIFE; VENOUS THROMBOEMBOLISM; POSTOPERATIVE NAUSEA;
ERADICATION THERAPY; SLEEVE GASTRECTOMY
AB Purpose. The perioperative management of bariatric surgery patients is described.
Summary. Obesity and anatomical changes create unique challenges for clinicians when caring for bariatric surgery patients. Common bariatric surgery procedures performed include Roux-en-Y gastric bypass, sleeve gastrectomy, and adjustable gastric banding. Pain management in the acute postoperative period depends on careful dosing of opioid agents and the use of adjunctive agents. Prevention and management of infectious complications include appropriate surgical prophylaxis, monitoring and rapid treatment of suspected intra-abdominal infections, and detection and treatment of Helicobacter pylori infection. Venous thromboembolism (VTE) prophylaxis and treatment are complicated by obesity, and the use of pharmacologic agents must be balanced with bleeding risk. Bleeding is a serious complication that should be closely monitored in the immediate postoperative period. Blood products remain first-line therapy for the treatment of bleeding in this population. Acute differences in drug absorption as well as emerging hormonal changes necessitate the immediate postoperative adjustment of chronic medications to ensure both safety and efficacy. Pharmacists are valuable members of interprofessional teams for bariatric surgery patients because they provide expertise on the availability of dosage forms and dosage modification to ensure that patient pharmacotherapy is not interrupted; assist in the management of hypertension, diabetes, and psychotropic medications; and ensure appropriate antimicrobial prophylaxis and VTE prophylaxis and treatment dosages.
Conclusion. The management of patients in the perioperative period of bariatric surgery requires appropriate selection and dosing of medications for pain management and treatment of infectious complications, VTE, bleeding, and other chronic diseases.
C1 [Quidley, April Miller] Vidant Med Ctr, Postgrad Year Crit Care Residency Program 2, Greenville, NC 27834 USA.
[Quidley, April Miller] Vidant Med Ctr, Greenville, NC USA.
[Bland, Christopher M.] Dwight D Eisenhower Army Med Ctr, Ft Gordon, GA USA.
[Bland, Christopher M.] Univ S Carolina, South Carolina Coll Pharm, Columbia, SC 29208 USA.
[Bookstaver, P. Brandon] Univ S Carolina, South Carolina Coll Pharm, Dept Clin Pharm & Outcomes Sci, Columbia, SC 29208 USA.
[Kuper, Kristi] VHA Performance Serv, Charlotte, NC USA.
RP Quidley, AM (reprint author), Vidant Med Ctr, Postgrad Year Crit Care Residency Program 2, Greenville, NC 27834 USA.
EM aprilmillerrx@gmail.com
NR 94
TC 3
Z9 5
U1 0
U2 9
PU AMER SOC HEALTH-SYSTEM PHARMACISTS
PI BETHESDA
PA 7272 WISCONSIN AVE, BETHESDA, MD 20814 USA
SN 1079-2082
EI 1535-2900
J9 AM J HEALTH-SYST PH
JI Am. J. Health-Syst. Pharm.
PD AUG 1
PY 2014
VL 71
IS 15
BP 1253
EP 1264
DI 10.2146/ajhp130679
PG 12
WC Pharmacology & Pharmacy
SC Pharmacology & Pharmacy
GA AM1ZI
UT WOS:000339647400009
PM 25027532
ER
PT J
AU Fowler, J
Mahlen, SD
AF Fowler, John
Mahlen, Steven D.
TI Localized Cutaneous Infections in Immunocompetent Individuals Due to
Rapidly Growing Mycobacteria
SO ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE
LA English
DT Article
ID NONTUBERCULOUS MYCOBACTERIA; CHELONAE INFECTION; SKIN; SUSCEPTIBILITY;
OUTBREAK; TATTOO
AB Rapidly growing mycobacteria (RGM) cause skin infections that are refractory to standard antibiotic regimens. Although typically associated with disseminated cutaneous or other systemic infections in immunocompromised patients, RGM sometimes cause localized cutaneous infections in immunocompetent hosts. These infections are almost always associated with precedent skin trauma and inoculation, and therefore have been implicated in outbreaks involving contaminated tattoo ink and inadequately sterilized acupuncture needles. Histologic features often include suppurative granulomatous inflammation, and microorganisms are rarely visualized with stains for acid-fast bacilli. The differential diagnosis includes granulomatous fungal and non-RGM bacterial infections as well as noninfectious suppurative or sarcoidlike conditions. Because no pathognomonic histologic features exist for cutaneous RGM infections, clinical suspicion and appropriate workup are essential to reach an accurate and timely diagnosis. Most localized cutaneous RGM infections in immunocompetent individuals respond well to either clarithromycin or amikacin, in combination with surgical debridement.
C1 [Fowler, John] Madigan Army Med Ctr, Pathol & Area Lab Serv, Tacoma, WA 98431 USA.
[Mahlen, Steven D.] Walter Reed Army Inst Res, Bacterial Dis Branch, Silver Spring, MD 20910 USA.
RP Mahlen, SD (reprint author), Walter Reed Army Inst Res, Bacterial Dis Branch, 503 Robert Grant Ave, Silver Spring, MD 20910 USA.
EM steven.mahlen@us.army.mil
NR 30
TC 3
Z9 3
U1 0
U2 2
PU COLL AMER PATHOLOGISTS
PI NORTHFIELD
PA C/O KIMBERLY GACKI, 325 WAUKEGAN RD, NORTHFIELD, IL 60093-2750 USA
SN 0003-9985
EI 1543-2165
J9 ARCH PATHOL LAB MED
JI Arch. Pathol. Lab. Med.
PD AUG
PY 2014
VL 138
IS 8
BP 1106
EP 1109
DI 10.5858/arpa.2012-0203-RS
PG 4
WC Medical Laboratory Technology; Medicine, Research & Experimental;
Pathology
SC Medical Laboratory Technology; Research & Experimental Medicine;
Pathology
GA AM1PN
UT WOS:000339619900020
PM 25076301
ER
PT J
AU Scharine, AA
Binseel, MS
Mermagen, T
Letowski, TR
AF Scharine, Angelique A.
Binseel, Mary S.
Mermagen, Timothy
Letowski, Tomasz R.
TI Sound localisation ability of soldiers wearing infantry ACH and PASGT
helmets
SO ERGONOMICS
LA English
DT Article
DE auditory situation awareness; sound localisation; helmets; monaural
localisation cues; spatial orientation
ID HUMAN LISTENERS
AB Helmets provide soldiers with ballistic and fragmentation protection but impair auditory spatial processing. Missed auditory information can be fatal for a soldier; therefore, helmet design requires compromise between protection and optimal acoustics. Twelve soldiers localised two sound signals presented from six azimuth angles and three levels of elevation presented at two intensity levels and with three background noises. Each participant completed the task while wearing no helmet and with two U.S. Army infantry helmets - the Personnel Armor System for Ground Troops (PASGT) helmet and the Advanced Combat Helmet (ACH). Results showed a significant effect of helmet type on the size of both azimuth and elevation error. The effects of level, background noise, azimuth and elevation were found to be significant. There was no effect of sound signal type. As hypothesised, localisation accuracy was greatest when soldiers did not wear helmet, followed by the ACH. Performance was worst with the PASGT helmet. Practitioner Summary: A soldier's headgear provides ballistic protection but decreases his ability to accurately localise sound sources. Soldiers performed a sound localisation task with no helmet and while wearing each of two Army helmets. The study confirmed that the ACH had less impact on auditory spatial perception than the PASGT helmet.
C1 [Scharine, Angelique A.; Binseel, Mary S.; Mermagen, Timothy; Letowski, Tomasz R.] US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA.
RP Scharine, AA (reprint author), US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA.
EM angelique.a.scharine.civ@mail.mil
NR 16
TC 0
Z9 0
U1 2
U2 12
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
SN 0014-0139
EI 1366-5847
J9 ERGONOMICS
JI Ergonomics
PD AUG
PY 2014
VL 57
IS 8
BP 1222
EP 1243
DI 10.1080/00140139.2014.917202
PG 22
WC Engineering, Industrial; Ergonomics; Psychology, Applied; Psychology
SC Engineering; Psychology
GA AL8QU
UT WOS:000339404800009
PM 24840132
ER
PT J
AU Yankowitz, M
Wang, JIJ
Birdwell, AG
Chen, YA
Watanabe, K
Taniguchi, T
Jacquod, P
San-Jose, P
Jarillo-Herrero, P
LeRoy, BJ
AF Yankowitz, Matthew
Wang, Joel I-Jan
Birdwell, A. Glen
Chen, Yu-An
Watanabe, K.
Taniguchi, T.
Jacquod, Philippe
San-Jose, Pablo
Jarillo-Herrero, Pablo
LeRoy, Brian J.
TI Electric field control of soliton motion and stacking in trilayer
graphene
SO NATURE MATERIALS
LA English
DT Article
ID BILAYER GRAPHENE; BORON-NITRIDE; ABA
AB The crystal structure of a material plays an important role in determining its electronic properties. Changing from one crystal structure to another involves a phase transition that is usually controlled by a state variable such as temperature or pressure. In the case of trilayer graphene, there are two common stacking configurations (Bernal and rhombohedral) that exhibit very different electronic properties(1-11). In graphene flakes with both stacking configurations, the region between them consists of a localized strain soliton where the carbon atoms of one graphene layer shift by the carbon-carbon bond distance(12-18). Here we show the ability to move this strain soliton with a perpendicular electric field and hence control the stacking configuration of trilayer graphene with only an external voltage. Moreover, we find that the free-energy difference between the two stacking configurations scales quadratically with electric field, and thus rhombohedral stacking is favoured as the electric field increases. This ability to control the stacking order in graphene opens the way to new devices that combine structural and electrical properties.
C1 [Yankowitz, Matthew; Jacquod, Philippe; LeRoy, Brian J.] Univ Arizona, Dept Phys, Tucson, AZ 85721 USA.
[Wang, Joel I-Jan; Chen, Yu-An; Jarillo-Herrero, Pablo] MIT, Dept Phys, Cambridge, MA 02138 USA.
[Wang, Joel I-Jan] Harvard Univ, Sch Engn & Appl Sci, Cambridge, MA 02138 USA.
[Birdwell, A. Glen] US Army, Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA.
[Watanabe, K.; Taniguchi, T.] Natl Inst Mat Sci, Tsukuba, Ibaraki 3050044, Japan.
[San-Jose, Pablo] CSIC, Inst Ciencia Mat Madrid, E-28049 Madrid, Spain.
RP LeRoy, BJ (reprint author), Univ Arizona, Dept Phys, Tucson, AZ 85721 USA.
EM leroy@physics.arizona.edu
RI San-Jose, Pablo/A-4795-2010; TANIGUCHI, Takashi/H-2718-2011; WATANABE,
Kenji/H-2825-2011; Jacquod, Philippe/J-6385-2016
OI San-Jose, Pablo/0000-0002-7920-5273; WATANABE,
Kenji/0000-0003-3701-8119; Jacquod, Philippe/0000-0002-0587-3535
FU US Army Research Laboratory; US Army Research Office [W911NF-09-1-0333];
Taiwan Merit Scholarship [TMS-094-1-A-001]; US DOE, BES Office, Division
of Materials Sciences and Engineering [DE-SC0001819]; NSF [DMR-0845287,
DMR-0819762, ECS-0335765]; ONR GATE MURI; Harvard's CNS; US Army
Research Laboratory (ARL) Director's Strategic Initiative; Spanish
Ministry of Economy (MINECO) [FIS2011-23713]; European Research Council
Advanced Grant [290846]; European Commission [CNECT-ICT-604391]
FX RS-J. acknowledges fruitful discussions with J. F. Rossier. M.Y. and
B.J.L. were supported by the US Army Research Laboratory and the US Army
Research Office under contract/grant number W911NF-09-1-0333. J.I-J.W.
was partially supported by a Taiwan Merit Scholarship TMS-094-1-A-001.
J.I-J.W and P.J-H. have been primarily supported by the US DOE, BES
Office, Division of Materials Sciences and Engineering under Award
DE-SC0001819. Early fabrication feasibility studies were supported by
NSF Career Award No. DMR-0845287 and the ONR GATE MURI. This work made
use of the MRSEC Shared Experimental Facilities supported by NSF under
award No. DMR-0819762 and of Harvard's CNS, supported by NSF under grant
No. ECS-0335765. A.G.B. was supported by the US Army Research Laboratory
(ARL) Director's Strategic Initiative program on interfaces in stacked
2D atomic layered materials. P.S-J. received financial support from the
Spanish Ministry of Economy (MINECO) through Grant no. FIS2011-23713,
the European Research Council Advanced Grant (contract 290846) and from
the European Commission under the Graphene Flagship (contract
CNECT-ICT-604391).
NR 24
TC 23
Z9 23
U1 2
U2 75
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1476-1122
EI 1476-4660
J9 NAT MATER
JI Nat. Mater.
PD AUG
PY 2014
VL 13
IS 8
BP 786
EP 789
DI 10.1038/NMAT3965
PG 4
WC Chemistry, Physical; Materials Science, Multidisciplinary; Physics,
Applied; Physics, Condensed Matter
SC Chemistry; Materials Science; Physics
GA AM1ZM
UT WOS:000339647800017
PM 24776537
ER
PT J
AU Taylor, ODS
McKenna, MH
Quinn, MCL
Quinn, BG
AF Taylor, Oliver-Denzil S.
McKenna, Mihan H.
Quinn, Meghan C. L.
Quinn, Brian G.
TI Partially saturated soil causing significant variability in near surface
seismic signals
SO NEAR SURFACE GEOPHYSICS
LA English
DT Article
ID PROPAGATION; STIFFNESS; EXPLOSIONS; ARRAYS; SANDS; RATIO
AB The behaviour of dry, moist, and saturated soils has been studied for over a century without adequately investigating the behaviour associated with transient saturation in the near surface, i.e. the upper 1 m of overburden, including the effects of rapid meteorological changes, dynamic fluid flow, and variability of saturation on shallow seismic sensors. This paper presents observational data wherein the geophysical instrumentation response was significantly influenced by near-surface post-precipitation saturation and additional laboratory experimentation on the effects of saturation on shear wave velocity. The lack of partially-saturated data is primarily because transient meteorological events have not been critically important to the types of long-term deployments performed in the past, where sensors were situated in hard-rock, collecting data under idealized conditions, as opposed to sedimentary settings. Shorter-duration deployments and smaller system architectures, e. g. persistent monitoring, now necessitate detailed a priori knowledge of meteorological impacts to system design and performance.
The purpose of this persistent monitoring geophysical instrumentation is to continually monitor the near surface and relate small perturbations to a specific source type(s) and distance(s) from the receiver. As such, the received signal is compared to known sources within a predetermined geological/meteorological condition. Presented herein is the calibration signal generated by a 3.63-kg (8-lb) sledgehammer prior to and post 36 hours of steady precipitation. The resulting subsurface seismic velocity time-histories show a significant increase in signal amplitude, change in frequency content and no change in duration. Thus, the amplification effects of near-surface moisture variability combined with dynamic pore fluid could be interpreted as false positives of a specific source signature and/or instrument failure.
C1 [Taylor, Oliver-Denzil S.; McKenna, Mihan H.; Quinn, Meghan C. L.; Quinn, Brian G.] US Army Engineer Res & Dev Ctr, Geotech & Struct Lab, CEERD GS S, Vicksburg, MS 39180 USA.
RP Taylor, ODS (reprint author), US Army Engineer Res & Dev Ctr, Geotech & Struct Lab, CEERD GS S, Bldg 5014,3909 Halls Ferry Rd, Vicksburg, MS 39180 USA.
EM Oliver.D.Taylor@usace.army.mil
NR 63
TC 1
Z9 1
U1 0
U2 5
PU EUROPEAN ASSOC GEOSCIENTISTS & ENGINEERS
PI 3990 DB, HOUTEN
PA PO BOX 59, 3990 DB, HOUTEN, 00000, NETHERLANDS
SN 1569-4445
EI 1873-0604
J9 NEAR SURF GEOPHYS
JI Near Surf. Geophys.
PD AUG
PY 2014
VL 12
IS 4
BP 467
EP 480
DI 10.3997/1873-0604.2013039
PG 14
WC Geochemistry & Geophysics
SC Geochemistry & Geophysics
GA AM1RA
UT WOS:000339624500002
ER
PT J
AU Holloway, JL
Lowman, AM
VanLandingham, MR
Palmese, GR
AF Holloway, Julianne L.
Lowman, Anthony M.
VanLandingham, Mark R.
Palmese, Giuseppe R.
TI Interfacial optimization of fiber-reinforced hydrogel composites for
soft fibrous tissue applications
SO ACTA BIOMATERIALIA
LA English
DT Article
DE Poly(vinyl alcohol); Hydrogel; Composite; Interfacial strength; Meniscus
ID NUCLEUS PULPOSUS REPLACEMENT; MECHANICAL-PROPERTIES;
ARTICULAR-CARTILAGE; PLASMA TREATMENT; ADHESION; POLYMER; MENISCUS;
BEHAVIOR; MODULUS
AB Meniscal tears are the most common orthopedic injuries to the human body, yet the current treatment of choice is a partial meniscectomy, which is known to lead to joint degeneration and osteoarthritis. As a result, there is a significant clinical need to develop materials capable of restoring function to the meniscus following an injury. Fiber-reinforced hydrogel composites are particularly suited for replicating the mechanical function of native fibrous tissues due to their ability to mimic the native anisotropic property distribution present. A critical issue with these materials, however, is the potential for the fiber-matrix interfacial properties to severely limit composite performance. In this work, the interfacial properties of an ultra-high-molecular-weight polyethylene (UHMWPE) fiber-reinforced poly(vinyl alcohol) (PVA) hydrogel are studied. A novel chemical grafting technique, confirmed using X-ray photoelectron spectroscopy, is used to improve UHMWPE-PVA interfacial adhesion. Interfacial shear strength is quantified using fiber pull-out tests. Results indicate significantly improved fiber-hydrogel interfacial adhesion after chemical grafting, where chemically grafted samples have an interfacial shear strength of 256.4 +/- 64.3 kPa compared to 11.5 +/- 2.9 kPa for untreated samples. Additionally, scanning electron microscopy of fiber surfaces after fiber pull-out reveal cohesive failure within the hydrogel matrix for treated fiber samples, indicating that the UHMWPE-PVA interface has been successfully optimized. Lastly, inter-fiber spacing is observed to have a significant effect on interfacial adhesion. Fibers spaced further apart have significantly higher interfacial shear strengths, which is critical to consider when optimizing composite design. The results in this study are applicable in developing similar chemical grafting techniques and optimizing fiber-matrix interfacial properties for other hydrogel-based composite systems. (C) 2014 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
C1 [Holloway, Julianne L.; Lowman, Anthony M.; Palmese, Giuseppe R.] Drexel Univ, Dept Chem & Biol Engn, Philadelphia, PA 19104 USA.
[VanLandingham, Mark R.] US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA.
RP Palmese, GR (reprint author), Drexel Univ, Dept Chem & Biol Engn, 3141 Chestnut St, Philadelphia, PA 19104 USA.
EM grp27@drexel.edu
FU National Defense Science and Engineering Graduate (NDSEG) Fellowship;
U.S. Army Research Laboratory through Army Materials Center of
Excellence Program [W911NF-06-2-0013]; NSF MRI-R2 Grant [CBET-0959361]
FX Funding was provided through the National Defense Science and
Engineering Graduate (NDSEG) Fellowship, in addition to funding by the
U.S. Army Research Laboratory through the Army Materials Center of
Excellence Program, Contract W911NF-06-2-0013. The authors also wish to
acknowledge Drexel University Core Research Facilities for use of the
XPS and SEM. In particular, the XPS instrumentation facility was made
possible by the NSF MRI-R2 Grant (CBET-0959361).
NR 29
TC 7
Z9 7
U1 5
U2 39
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1742-7061
EI 1878-7568
J9 ACTA BIOMATER
JI Acta Biomater.
PD AUG
PY 2014
VL 10
IS 8
BP 3581
EP 3589
DI 10.1016/j.actbio.2014.05.004
PG 9
WC Engineering, Biomedical; Materials Science, Biomaterials
SC Engineering; Materials Science
GA AL9KH
UT WOS:000339459500021
PM 24814880
ER
PT J
AU Leung, LY
Larimore, Z
Holmes, L
Cartagena, C
Mountney, A
Deng-Bryant, Y
Schmid, K
Shear, D
Tortella, F
AF Leung, Lai Yee
Larimore, Zachary
Holmes, Larry
Cartagena, Casandra
Mountney, Andrea
Deng-Bryant, Ying
Schmid, Kara
Shear, Deborah
Tortella, Frank
TI The WRAIR Projectile Concussive Impact Model of Mild Traumatic Brain
Injury: Re-design, Testing and Preclinical Validation
SO ANNALS OF BIOMEDICAL ENGINEERING
LA English
DT Article
DE Concussion; Mild TBI; Projectile; Helmet; Impact energy; Head
kinematics; Gait
ID AMYLOID PRECURSOR PROTEIN; DIFFUSE AXONAL INJURY; SOMATOSENSORY CORTEX;
ANIMAL-MODELS; HEAD-INJURY; RAT; LOCOMOTION; BETA; MICE; GAIT
AB The WRAIR projectile concussive impact (PCI) model was developed for preclinical study of concussion. It represents a truly non-invasive closed-head injury caused by a blunt impact. The original design, however, has several drawbacks that limit the manipulation of injury parameters. The present study describes engineering advancements made to the PCI injury model including helmet material testing, projectile impact energy/head kinematics and impact location. Material testing indicated that among the tested materials, 'fiber-glass/carbon' had the lowest elastic modulus and yield stress for providing an relative high percentage of load transfer from the projectile impact, resulting in significant hippocampal astrocyte activation. Impact energy testing of small projectiles, ranging in shape and size, showed the steel sphere produced the highest impact energy and the most consistent impact characteristics. Additional tests confirmed the steel sphere produced linear and rotational motions on the rat's head while remaining within a range that meets the criteria for mTBI. Finally, impact location testing results showed that PCI targeted at the temporoparietal surface of the rat head produced the most prominent gait abnormalities. Using the parameters defined above, pilot studies were conducted to provide initial validation of the PCI model demonstrating quantifiable and significant increases in righting reflex recovery time, axonal damage and astrocyte activation following single and multiple concussions.
C1 [Leung, Lai Yee; Cartagena, Casandra; Mountney, Andrea; Deng-Bryant, Ying; Schmid, Kara; Shear, Deborah; Tortella, Frank] WRAIR, Ctr Mil Psychiat & Neurosci, Brain Trauma Neuroprotect & Neurorestorat Branch, Silver Spring, MD 20910 USA.
[Larimore, Zachary; Holmes, Larry] United States Army Res Labs, Composites & Hybrid Mat Branch, Aberdeen, MD USA.
RP Leung, LY (reprint author), WRAIR, Ctr Mil Psychiat & Neurosci, Brain Trauma Neuroprotect & Neurorestorat Branch, 503 Robert Grant Ave, Silver Spring, MD 20910 USA.
EM laiyee.leung@us.army.mil
FU Combat Casualty Care Research Program; Congressionally Directed Medical
Research Program [W81XWH-12-2-0134]
FX The views of the authors do not purport or reflect the position of the
Department of the Army or the Department of Defense (para 4-3, AR
360-5). The authors declare that there are no conflicts of interest in
this study. This research is funded by Combat Casualty Care Research
Program and Congressionally Directed Medical Research Program (Contract
#: W81XWH-12-2-0134). The authors would like to thank Weihong Yang,
Francis Bustos, Megan Winter, David Miles and SGT Shawn McLoughlin for
technical supports.
NR 30
TC 3
Z9 3
U1 1
U2 12
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0090-6964
EI 1573-9686
J9 ANN BIOMED ENG
JI Ann. Biomed. Eng.
PD AUG
PY 2014
VL 42
IS 8
BP 1618
EP 1630
DI 10.1007/s10439-014-1014-8
PG 13
WC Engineering, Biomedical
SC Engineering
GA AL8OP
UT WOS:000339399000004
PM 24756867
ER
PT J
AU Nanayakkara, NPD
Tekwani, BL
Herath, HMTB
Sahu, R
Gettayacamin, M
Tungtaeng, A
van Gessel, Y
Baresel, P
Wickham, KS
Bartlett, MS
Fronczek, FR
Melendez, V
Ohrt, C
Reichard, GA
McChesney, JD
Rochford, R
Walker, LA
AF Nanayakkara, N. P. Dhammika
Tekwani, Babu L.
Herath, H. M. T. Bandara
Sahu, Rajnish
Gettayacamin, Montip
Tungtaeng, Anchalee
van Gessel, Yvonne
Baresel, Paul
Wickham, Kristina S.
Bartlett, Marilyn S.
Fronczek, Frank R.
Melendez, Victor
Ohrt, Colin
Reichard, Gregory A.
McChesney, James D.
Rochford, Rosemary
Walker, Larry A.
TI Scalable Preparation and Differential Pharmacologic and Toxicologic
Profiles of Primaquine Enantiomers
SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
LA English
DT Article
ID ANTIMALARIAL-DRUG PRIMAQUINE; PNEUMOCYSTIS-CARINII; HUMAN-ERYTHROCYTES;
METABOLITES; METHEMOGLOBIN; ANALOGS; ACID; PHARMACOKINETICS;
GLUTATHIONE; TOXICITIES
AB Hematotoxicity in individuals genetically deficient in glucose-6-phosphate dehydrogenase (G6PD) activity is the major limitation of primaquine (PQ), the only antimalarial drug in clinical use for treatment of relapsing Plasmodium vivax malaria. PQ is currently clinically used in its racemic form. A scalable procedure was developed to resolve racemic PQ, thus providing pure enantiomers for the first time for detailed preclinical evaluation and potentially for clinical use. These enantiomers were compared for antiparasitic activity using several mouse models and also for general and hematological toxicities in mice and dogs. (+)-(S)-PQ showed better suppressive and causal prophylactic activity than (-)-(R)-PQ in mice infected with Plasmodium berghei. Similarly, (+)-(S)-PQ was a more potent suppressive agent than (-)-(R)-PQ in a mouse model of Pneumocystis carinii pneumonia. However, at higher doses, (+)-(S)-PQ also showed more systemic toxicity for mice. In beagle dogs, (+)-(S)-PQ caused more methemoglobinemia and was toxic at 5 mg/kg of body weight/day given orally for 3 days, while (-)-(R)-PQ was well tolerated. In a novel mouse model of hemolytic anemia associated with human G6PD deficiency, it was also demonstrated that (-)-(R)-PQ was less hemolytic than (+)-(S)-PQ for the G6PD-deficient human red cells engrafted in the NOD-SCID mice. All these data suggest that while (+)-(S)-PQ shows greater potency in terms of antiparasitic efficacy in rodents, it is also more hematotoxic than (-)-(R)-PQ in mice and dogs. Activity and toxicity differences of PQ enantiomers in different species can be attributed to their different pharmacokinetic and metabolic profiles. Taken together, these studies suggest that (-)-(R)-PQ may have a better safety margin than the racemate in human.
C1 [Nanayakkara, N. P. Dhammika; Tekwani, Babu L.; Herath, H. M. T. Bandara; Sahu, Rajnish; Walker, Larry A.] Univ Mississippi, Natl Ctr Nat Prod Res, Res Inst Pharmaceut Sci, University, MS 38677 USA.
[Tekwani, Babu L.; Walker, Larry A.] Univ Mississippi, Dept Pharmacol, University, MS 38677 USA.
[Gettayacamin, Montip; Tungtaeng, Anchalee; van Gessel, Yvonne] AFRIMS, US Army Med Component, Dept Vet Med, Bangkok, Thailand.
[Baresel, Paul; Wickham, Kristina S.; Rochford, Rosemary] SUNY Upstate Med Univ, Dept Microbiol & Immunol, Syracuse, NY 13210 USA.
[Bartlett, Marilyn S.] Indiana Univ, Sch Med, Dept Pathol & Lab Med, Indianapolis, IN USA.
[Fronczek, Frank R.] Louisiana State Univ, Dept Chem, Baton Rouge, LA 70803 USA.
[Melendez, Victor; Ohrt, Colin; Reichard, Gregory A.] Walter Reed Army Inst Res, Dept Expt Therapeut, Silver Spring, MD USA.
[McChesney, James D.] Ironstone Separat Inc, Etta, MS USA.
RP Nanayakkara, NPD (reprint author), Univ Mississippi, Natl Ctr Nat Prod Res, Res Inst Pharmaceut Sci, University, MS 38677 USA.
EM dhammika@olemiss.edu
FU Bill & Melinda Gates Foundation [OPP53288]; Army Medical Research &
Materiel Command [W81XWH-07-2-0095, W81XWH-10-2-0059]; USDA-ARS
[58-6408-2-0009]
FX This study received financial support from the Bill & Melinda Gates
Foundation (Phase I Grand Challenges Explorations Award no. OPP53288)
and Army Medical Research & Materiel Command (grants no.
W81XWH-07-2-0095 and W81XWH-10-2-0059). The NCNPR is also supported by
USDA-ARS scientific cooperative agreement no. 58-6408-2-0009.
NR 40
TC 6
Z9 6
U1 1
U2 4
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0066-4804
EI 1098-6596
J9 ANTIMICROB AGENTS CH
JI Antimicrob. Agents Chemother.
PD AUG
PY 2014
VL 58
IS 8
BP 4737
EP 4744
DI 10.1128/AAC.02674-13
PG 8
WC Microbiology; Pharmacology & Pharmacy
SC Microbiology; Pharmacology & Pharmacy
GA AL6RA
UT WOS:000339259200058
PM 24913163
ER
PT J
AU Chen, NH
LaCrue, AN
Teuscher, F
Waters, NC
Gatton, ML
Kyle, DE
Cheng, Q
AF Chen, Nanhua
LaCrue, Alexis N.
Teuscher, Franka
Waters, Norman C.
Gatton, Michelle L.
Kyle, Dennis E.
Cheng, Qin
TI Fatty Acid Synthesis and Pyruvate Metabolism Pathways Remain Active in
Dihydroartemisinin-Induced Dormant Ring Stages of Plasmodium falciparum
SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
LA English
DT Article
ID TOXOPLASMA-GONDII; ANTIBIOTIC TOLERANCE; MALARIA PARASITES; ARTEMISININ;
APICOPLAST; CULTURE; GROWTH; PERSISTENCE; INHIBITION; RESISTANCE
AB Artemisinin (ART)-based combination therapy (ACT) is used as the first-line treatment of uncomplicated falciparum malaria worldwide. However, despite high potency and rapid action, there is a high rate of recrudescence associated with ART monotherapy or ACT long before the recent emergence of ART resistance. ART-induced ring-stage dormancy and recovery have been implicated as possible causes of recrudescence; however, little is known about the characteristics of dormant parasites, including whether dormant parasites are metabolically active. We investigated the transcription of 12 genes encoding key enzymes in various metabolic pathways in P. falciparum during dihydroartemisinin (DHA)-induced dormancy and recovery. Transcription analysis showed an immediate downregulation for 10 genes following exposure to DHA but continued transcription of 2 genes encoding apicoplast and mitochondrial proteins. Transcription of several additional genes encoding apicoplast and mitochondrial proteins, particularly of genes encoding enzymes in pyruvate metabolism and fatty acid synthesis pathways, was also maintained. Additions of inhibitors for biotin acetyl-coenzyme A (CoA) carboxylase and enoyl-acyl carrier reductase of the fatty acid synthesis pathways delayed the recovery of dormant parasites by 6 and 4 days, respectively, following DHA treatment. Our results demonstrate that most metabolic pathways are downregulated in DHA-induced dormant parasites. In contrast, fatty acid and pyruvate metabolic pathways remain active. These findings highlight new targets to interrupt recovery of parasites from ART-induced dormancy and to reduce the rate of recrudescence following ART treatment.
C1 [Chen, Nanhua; Teuscher, Franka; Cheng, Qin] Australian Army Malaria Inst, Brisbane, Qld, Australia.
[LaCrue, Alexis N.; Kyle, Dennis E.] Univ S Florida, Dept Global Hlth, Tampa, FL USA.
[Teuscher, Franka; Gatton, Michelle L.; Cheng, Qin] Queensland Inst Med Res, Brisbane, Qld, Australia.
[Waters, Norman C.] Walter Reed Army Inst Res, Silver Spring, MD USA.
[Gatton, Michelle L.] Queensland Univ Technol, Sch Publ Hlth & Social Work, Brisbane, Qld 4001, Australia.
RP Cheng, Q (reprint author), Australian Army Malaria Inst, Brisbane, Qld, Australia.
EM qin.cheng@defence.gov.au
OI Gatton, Michelle/0000-0003-1188-609X
FU NIH [RO1AI058973]; NHMRC [APP1021273]
FX This work was partially funded by a NIH grant (RO1AI058973) and a NHMRC
grant (APP1021273).
NR 43
TC 15
Z9 15
U1 0
U2 8
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0066-4804
EI 1098-6596
J9 ANTIMICROB AGENTS CH
JI Antimicrob. Agents Chemother.
PD AUG
PY 2014
VL 58
IS 8
BP 4773
EP 4781
DI 10.1128/AAC.02647-14
PG 9
WC Microbiology; Pharmacology & Pharmacy
SC Microbiology; Pharmacology & Pharmacy
GA AL6RA
UT WOS:000339259200063
PM 24913167
ER
PT J
AU Dyall, J
Coleman, CM
Hart, BJ
Venkataraman, T
Holbrook, MR
Kindrachuk, J
Johnson, RF
Olinger, GG
Jahrling, PB
Laidlaw, M
Johansen, LM
Lear-Rooney, CM
Glass, PJ
Hensley, LE
Frieman, MB
AF Dyall, Julie
Coleman, Christopher M.
Hart, Brit J.
Venkataraman, Thiagarajan
Holbrook, Michael R.
Kindrachuk, Jason
Johnson, Reed F.
Olinger, Gene G., Jr.
Jahrling, Peter B.
Laidlaw, Monique
Johansen, Lisa M.
Lear-Rooney, Calli M.
Glass, Pamela J.
Hensley, Lisa E.
Frieman, Matthew B.
TI Repurposing of Clinically Developed Drugs for Treatment of Middle East
Respiratory Syndrome Coronavirus Infection
SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
LA English
DT Article
ID CHRONIC MYELOID-LEUKEMIA; MERS-COV; SAUDI-ARABIA; BALB/C MICE; VIRUS;
REPLICATION; CELLS; ENTRY; CHLORPROMAZINE; INHIBITORS
AB Outbreaks of emerging infections present health professionals with the unique challenge of trying to select appropriate pharmacologic treatments in the clinic with little time available for drug testing and development. Typically, clinicians are left with general supportive care and often untested convalescent-phase plasma as available treatment options. Repurposing of approved pharmaceutical drugs for new indications presents an attractive alternative to clinicians, researchers, public health agencies, drug developers, and funding agencies. Given the development times and manufacturing requirements for new products, repurposing of existing drugs is likely the only solution for outbreaks due to emerging viruses. In the studies described here, a library of 290 compounds was screened for antiviral activity against Middle East respiratory syndrome coronavirus (MERS-CoV) and severe acute respiratory syndrome coronavirus (SARS-CoV). Selection of compounds for inclusion in the library was dependent on current or previous FDA approval or advanced clinical development. Some drugs that had a well-defined cellular pathway as target were included. In total, 27 compounds with activity against both MERS-CoV and SARS-CoV were identified. The compounds belong to 13 different classes of pharmaceuticals, including inhibitors of estrogen receptors used for cancer treatment and inhibitors of dopamine receptor used as antipsychotics. The drugs identified in these screens provide new targets for in vivo studies as well as incorporation into ongoing clinical studies.
C1 [Dyall, Julie; Hart, Brit J.; Holbrook, Michael R.; Kindrachuk, Jason; Olinger, Gene G., Jr.; Jahrling, Peter B.; Hensley, Lisa E.] NIAID, Integrated Res Facil, NIH, Frederick, MD 21702 USA.
[Coleman, Christopher M.; Venkataraman, Thiagarajan; Frieman, Matthew B.] Univ Maryland, Sch Med, Dept Microbiol & Immunol, Baltimore, MD 21201 USA.
[Johnson, Reed F.; Jahrling, Peter B.] NIAID, Emerging Viral Pathogens Sect, NIH, Frederick, MD USA.
[Laidlaw, Monique; Johansen, Lisa M.] Zalicus Inc, Cambridge, MA USA.
[Lear-Rooney, Calli M.; Glass, Pamela J.] US Army Med Res Inst Infect Dis, Frederick, MD USA.
RP Frieman, MB (reprint author), NIAID, Integrated Res Facil, NIH, Frederick, MD 21702 USA.
EM MFrieman@som.umaryland.edu
RI Hart, Brit/G-6205-2015
OI Kindrachuk, Jason/0000-0002-3305-7084; Venkataraman,
Thiagarajan/0000-0003-0921-6345; Hart, Brit/0000-0002-9389-2786
FU Division of Intramural Research of the National Institute of Allergy and
Infectious Diseases (NIAID); Integrated Research Facility (NIAID,
Division of Clinical Research); Battelle Memorial Institute's prime
contract with NIAID [HHSN2722007000161]; NIH [R01AI1095569]; U.S. Army
Research Institute of Infectious Diseases (USAMRIID) [W81XWH-12-2-0064]
FX This work was supported by the Division of Intramural Research of the
National Institute of Allergy and Infectious Diseases (NIAID), the
Integrated Research Facility (NIAID, Division of Clinical Research), the
Battelle Memorial Institute's prime contract with NIAID (contract number
HHSN2722007000161) and NIH grant R01AI1095569 (to M. B. F.), and a
subcontract (W81XWH-12-2-0064) awarded to L.M.J. from the U.S. Army
Research Institute of Infectious Diseases (USAMRIID).
NR 46
TC 46
Z9 50
U1 1
U2 16
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0066-4804
EI 1098-6596
J9 ANTIMICROB AGENTS CH
JI Antimicrob. Agents Chemother.
PD AUG
PY 2014
VL 58
IS 8
BP 4885
EP 4893
DI 10.1128/AAC.03036-14
PG 9
WC Microbiology; Pharmacology & Pharmacy
SC Microbiology; Pharmacology & Pharmacy
GA AL6RA
UT WOS:000339259200074
PM 24841273
ER
PT J
AU Nguyen, ST
Williams, JD
Butler, MM
Ding, X
Mills, DM
Tashjian, TF
Panchal, RG
Weir, SK
Moon, C
Kim, HO
Marsden, JA
Peet, NP
Bowlin, TL
AF Nguyen, Son T.
Williams, John D.
Butler, Michelle M.
Ding, Xiaoyuan
Mills, Debra M.
Tashjian, Tommy F.
Panchal, Rekha G.
Weir, Susan K.
Moon, Chaeho
Kim, Hwa-Ok
Marsden, Jeremiah A.
Peet, Norton P.
Bowlin, Terry L.
TI Synthesis and antibacterial evaluation of new, unsymmetrical triaryl
bisamidine compounds
SO BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
LA English
DT Article
ID ANTIBIOTICS; INDOLES; DESIGN; POTENT
AB Herein we describe the synthesis and antibacterial evaluation of a new, unsymmetrical triaryl bisamidine compound series, [Am]-[indole]-[linker]-[HetAr/Ar]-[Am], in which [Am] is an amidine or amino group, [linker] is a benzene, thiophene or pyridine ring, and [HetAr/Ar] is a benzimidazole, imidazopyridine, benzofuran, benzothiophene, pyrimidine or benzene ring. When the [HetAr/Ar] unit is a 5,6-bicyclic heterocycle, it is oriented such that the 5-membered ring portion is connected to the [linker] unit and the 6-membered ring portion is connected to the [Am] unit. Among the 34 compounds in this series, compounds with benzofuran as the [HetAr/Ar] unit showed the highest potencies. Introduction of a fluorine atom or a methyl group to the triaryl core led to the more potent analogs. Bisamidines are more active toward bacteria while the monoamidines are more active toward mammalian cells (as indicated by low CC50 values). Importantly, we identified compound P12a (MBX 1887) with a relatively narrow spectrum against bacteria and a very high CC50 value. Compound P12a has been scaled up and is currently undergoing further evaluations for therapeutic applications. (C) 2014 Elsevier Ltd. All rights reserved.
C1 [Nguyen, Son T.; Williams, John D.; Butler, Michelle M.; Ding, Xiaoyuan; Mills, Debra M.; Tashjian, Tommy F.; Peet, Norton P.; Bowlin, Terry L.] Microbiotix Inc, Worcester, MA 01604 USA.
[Panchal, Rekha G.] US Army Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA.
[Weir, Susan K.] Boston Univ, Sch Med, Dept Med, Boston, MA 02118 USA.
[Moon, Chaeho; Kim, Hwa-Ok] CreaGen Biosci Inc, Woburn, MA 01801 USA.
[Marsden, Jeremiah A.] Organ Consultants Inc, Eugene, OR 97401 USA.
RP Nguyen, ST (reprint author), Microbiotix Inc, 1 Innovat Dr, Worcester, MA 01604 USA.
EM snguyen@microbiotix.com
FU National Institute of Allergy and Infectious Disease of the National
Institutes of Health [U01AI082052, R43AI83032]
FX Research reported in this article was generously supported by the
National Institute of Allergy and Infectious Disease of the National
Institutes of Health under award numbers U01AI082052 and R43AI83032. The
content is solely the responsibility of the authors and does not
necessarily represent the official views of the National Institutes of
Health.
NR 22
TC 6
Z9 6
U1 1
U2 6
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0960-894X
EI 1464-3405
J9 BIOORG MED CHEM LETT
JI Bioorg. Med. Chem. Lett.
PD AUG 1
PY 2014
VL 24
IS 15
BP 3366
EP 3372
DI 10.1016/j.bmcl.2014.05.094
PG 7
WC Chemistry, Medicinal; Chemistry, Organic
SC Pharmacology & Pharmacy; Chemistry
GA AL6FT
UT WOS:000339228700029
PM 24969013
ER
PT J
AU Owens, BD
AF Owens, Brett D.
TI CORR Insights (R): External Rotation Immobilization for Primary Shoulder
Dislocation: A Randomized Controlled Trial
SO CLINICAL ORTHOPAEDICS AND RELATED RESEARCH
LA English
DT Editorial Material
ID TRAUMATIC ANTERIOR DISLOCATION; RECURRENCE; RISK
C1 Keller Army Community Hosp, Dept Orthopaed, West Point, NY 10996 USA.
RP Owens, BD (reprint author), Keller Army Community Hosp, Dept Orthopaed, 900 Washington Rd, West Point, NY 10996 USA.
EM b.owens@us.army.mil
NR 7
TC 0
Z9 0
U1 0
U2 1
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0009-921X
EI 1528-1132
J9 CLIN ORTHOP RELAT R
JI Clin. Orthop. Rel. Res.
PD AUG
PY 2014
VL 472
IS 8
BP 2387
EP 2388
DI 10.1007/s11999-014-3466-4
PG 2
WC Orthopedics; Surgery
SC Orthopedics; Surgery
GA AL3AK
UT WOS:000338997100014
PM 24488751
ER
PT J
AU Shang, SL
Wang, Y
Du, Y
Tschopp, MA
Liu, ZK
AF Shang, ShunLi
Wang, Yi
Du, Yong
Tschopp, Mart A.
Liu, Zi-Kui
TI Integrating computational modeling and first-principles calculations to
predict stacking fault energy of dilute multicomponent Ni-base alloys
SO COMPUTATIONAL MATERIALS SCIENCE
LA English
DT Article
DE Stacking fault energy; First-principles calculations; CALPHAD modeling
approach; Alias shear deformation; Multicomponent Ni-base alloys
ID HIGH-TEMPERATURE CREEP; DEFORMATION; METALS; PHASES
AB Stacking fault energy (gamma(SF)) for dilute multicomponent Ni-base alloys has been modeled using an integrating CALPHAD (calculation of phase diagram) modeling approach and first-principles alias shear deformation calculations of unary, binary, and ternary alloys. The present first-principles results of gamma(SF) from 55 Ni70X1Y1 (X and Y are 11 alloying elements of Al, Mo, Nb, Os, Re, Ru, Ta, Tc, Ti, V, and W) indicate that the more the structural similarity between X and Y, the smaller the ternary interaction of gamma(SF); and the variation of gamma(SF) due to alloying elements is similar to that of bulk modulus. (C) 2014 Elsevier B.V. All rights reserved.
C1 [Shang, ShunLi; Wang, Yi; Liu, Zi-Kui] Penn State Univ, Dept Mat Sci & Engn, University Pk, PA 16802 USA.
[Du, Yong] Cent S Univ, State Key Lab Powder Met, Changsha 410083, Hunan, Peoples R China.
[Tschopp, Mart A.] US Army, Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA.
RP Shang, SL (reprint author), Penn State Univ, Dept Mat Sci & Engn, University Pk, PA 16802 USA.
EM sus26@psu.edu
RI Shang, Shun-Li/A-6564-2009; Wang, Yi/D-1032-2013; Liu,
Zi-Kui/A-8196-2009;
OI Shang, Shun-Li/0000-0002-6524-8897; Liu, Zi-Kui/0000-0003-3346-3696;
Tschopp, Mark/0000-0001-8471-5035
FU Office of Naval Research (ONR) of the United States [N0014-07-1-0638];
Center for Computational Materials Design; U.S. NSF Industry/University
Cooperative Research Center at Penn State [IIP-1034965]; Georgia Tech
[IIP-1034968]; Materials Simulation Center and the Research Computing
and Cyber infrastructure unit at Penn State; Office of Science of the US
DOE [DE-ACO2-05CH11231]; NSF of China [51028101]
FX This work was funded by the Office of Naval Research (ONR) of the United
States under contract No. N0014-07-1-0638 and the Center for
Computational Materials Design, a joint U.S. NSF Industry/University
Cooperative Research Center at Penn State (IIP-1034965) and Georgia Tech
(IIP-1034968). First-principles calculations were carried out partially
on the LION clusters supported by the Materials Simulation Center and
the Research Computing and Cyber infrastructure unit at Penn State, and
partially on the resources of NERSC supported by the Office of Science
of the US DOE (DE-ACO2-05CH11231). ZKL and YD would like to thank the
support from NSF of China (51028101).
NR 36
TC 3
Z9 3
U1 6
U2 37
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0927-0256
EI 1879-0801
J9 COMP MATER SCI
JI Comput. Mater. Sci.
PD AUG
PY 2014
VL 91
BP 50
EP 55
DI 10.1016/j.commatsci.2014.04.040
PG 6
WC Materials Science, Multidisciplinary
SC Materials Science
GA AL4UA
UT WOS:000339129100009
ER
PT J
AU Glasgow, SC
Heafner, TA
Watson, JDB
Aden, JK
Perry, WB
AF Glasgow, Sean C.
Heafner, Thomas A.
Watson, J. Devin B.
Aden, James K.
Perry, W. Brian
TI Initial Management and Outcome of Modern Battlefield Anal Trauma
SO DISEASES OF THE COLON & RECTUM
LA English
DT Article
DE Anorectal surgery; Ostomy; Outcomes research; Colorectal surgery;
General surgery; Trauma
ID OPERATION IRAQI FREEDOM; RECTAL INJURIES; SURGICAL-MANAGEMENT; ENDURING
FREEDOM; SPHINCTER REPAIR; COMBAT WOUNDS; COLOSTOMY; EPIDEMIOLOGY; COLON
AB BACKGROUND: Despite the potential for morbidity and permanent lifestyle alteration, few reports exist examining traumatic injury to the anal canal, particularly among modern-day combatants.
OBJECTIVE: The aim of this study was to document the incidence, initial surgical management, and long-term outcomes of wartime anal trauma.
DESIGN: This study is a retrospective review.
DATA SOURCES: Data were compiled from multiple electronic medical record systems, including the Department of Defense Trauma Registry, the Patient Administration Systems and Biostatistics Activity, and the Armed Forces Health Longitudinal Tracking Application.
SETTINGS: Combatants were treated at military treatment facilities with surgical capability during the wars in Iraq and Afghanistan, 2003 through early 2011.
PATIENTS: All US and coalition combatants sustaining trauma to the anal canal or sphincter musculature were included.
MAIN OUTCOME MEASURES: The quantification of incidence, the evaluation of initial treatment approach, and the determination of clinical and surgical factors correlating with restoration or preservation of GI tract continuity were the primary outcomes measured.
RESULTS: Anal trauma occurred in 46 combatants, predominantly from blast injury (76.1%). Most (36, 78.2%) underwent fecal diversion. Concurrent severe systemic or intra-abdominal injuries correlated with colostomy creation. Acute anoplasty was attempted in 11 patients (23.7%) but did not influence eventual colostomy reversal. Among 33 US personnel, the permanent colostomy rate was 30.3%. Concurrent injury to the abdomen strongly predicted long-term colostomy (p = 0.009), along with hypogastric arterial ligation (p = 0.05) and pelvic fracture (p = 0.06).
LIMITATIONS: This study was limited by the potential underdiagnosis of anal injury and the restricted follow-up of non-US personnel.
CONCLUSIONS: Other injuries besides anal trauma typically have guided the decision for fecal diversion, and acute anal repair has rarely been indicated. The majority of patients with anal trauma regained normal GI continuity, although certain pelvic injuries increased the likelihood of permanent colostomy.
C1 [Glasgow, Sean C.] St Louis Univ, Dept Surg, St Louis, MO 63110 USA.
[Glasgow, Sean C.] US Air Force, Ctr Sustainment Trauma & Readiness Skills, St Louis, MO USA.
[Heafner, Thomas A.; Watson, J. Devin B.] San Antonio Mil Med Ctr, Dept Surg, Ft Sam Houston, TX USA.
[Aden, James K.] US Army, Inst Surg Res, Ft Sam Houston, TX 78234 USA.
[Perry, W. Brian] Audie L Murphy Vet Hosp, San Antonio, TX USA.
RP Glasgow, SC (reprint author), St Louis Univ, Dept Surg, 3635 Vista & Grand Blvd,3 FDT, St Louis, MO 63110 USA.
EM glasgowsc@slu.edu
FU Defense Health Program [6.7 FY12]
FX Research was funded in part by Defense Health Program 6.7 FY12 grant,
"Quality of Life and Obstacles to Care in Injured Personnel with
Ostomies," principle investigator Major Sean C. Glasgow.
NR 32
TC 1
Z9 1
U1 0
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0012-3706
EI 1530-0358
J9 DIS COLON RECTUM
JI Dis. Colon Rectum
PD AUG
PY 2014
VL 57
IS 8
BP 1012
EP 1018
DI 10.1097/DCR.0000000000000141
PG 7
WC Gastroenterology & Hepatology; Surgery
SC Gastroenterology & Hepatology; Surgery
GA AL6KO
UT WOS:000339241500015
PM 25003297
ER
PT J
AU Burtnick, MN
Brett, PJ
DeShazer, D
AF Burtnick, Mary N.
Brett, Paul J.
DeShazer, David
TI Proteomic Analysis of the Burkholderia pseudomallei Type II Secretome
Reveals Hydrolytic Enzymes, Novel Proteins, and the Deubiquitinase TssM
SO INFECTION AND IMMUNITY
LA English
DT Article
ID OUTER-MEMBRANE INTEGRITY; GRAM-NEGATIVE BACTERIA; VIRULENCE IN-VIVO;
ESCHERICHIA-COLI; MOLECULAR CHARACTERIZATION; PSEUDOMONAS-PSEUDOMALLEI;
MASS-SPECTROMETRY; SIGNAL PEPTIDES; SYSTEM; MALLEI
AB Burkholderia pseudomallei, the etiologic agent of melioidosis, is an opportunistic pathogen that harbors a wide array of secretion systems, including a type II secretion system (T2SS), three type III secretion systems (T3SS), and six type VI secretion systems (T6SS). The proteins exported by these systems provide B. pseudomallei with a growth advantage in vitro and in vivo, but relatively little is known about the full repertoire of exoproducts associated with each system. In this study, we constructed deletion mutations in gspD and gspE, T2SS genes encoding an outer membrane secretin and a cytoplasmic ATPase, respectively. The secretion profiles of B. pseudomallei MSHR668 and its T2SS mutants were noticeably different when analyzed by SDS-PAGE. We utilized liquid chromatography-tandem mass spectrometry (LC-MS/MS) to identify proteins present in the supernatants of B. pseudomallei MSHR668 and B. pseudomallei Delta gspD grown in rich and minimal media. The MSHR668 supernatants contained 48 proteins that were either absent or substantially reduced in the supernatants of Delta gspD strains. Many of these proteins were putative hydrolytic enzymes, including 12 proteases, two phospholipases, and a chitinase. Biochemical assays validated the LCMS/MS results and demonstrated that the export of protease, phospholipase C, and chitinase activities is T2SS dependent. Previous studies had failed to identify the mechanism of secretion of TssM, a deubiquitinase that plays an integral role in regulating the innate immune response. Here we present evidence that TssM harbors an atypical signal sequence and that its secretion is mediated by the T2SS. This study provides the first in-depth characterization of the B. pseudomallei T2SS secretome.
C1 [Burtnick, Mary N.; Brett, Paul J.] Univ S Alabama, Dept Microbiol & Immunol, Mobile, AL 36688 USA.
[DeShazer, David] US Army, Med Res Inst Infect Dis, Bacteriol Div, Frederick, MD 21702 USA.
RP DeShazer, D (reprint author), US Army, Med Res Inst Infect Dis, Bacteriol Div, Frederick, MD 21702 USA.
EM david.deshazer.civ@mail.mil
FU DTRA/JSTO-CBD [CBCALL12-LS1-2-0070]; National Institute of Allergy and
Infectious Diseases [AI065359, AI091783]
FX This project received support from DTRA/JSTO-CBD proposal number
CBCALL12-LS1-2-0070 (to D.D.). This project was also supported in part
by awards AI065359 (to M.N.B) and AI091783 (to P.J.B.) from the National
Institute of Allergy and Infectious Diseases.
NR 63
TC 14
Z9 14
U1 0
U2 14
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0019-9567
EI 1098-5522
J9 INFECT IMMUN
JI Infect. Immun.
PD AUG
PY 2014
VL 82
IS 8
BP 3214
EP 3226
DI 10.1128/IAI.01739-14
PG 13
WC Immunology; Infectious Diseases
SC Immunology; Infectious Diseases
GA AL5GK
UT WOS:000339161400012
PM 24866793
ER
PT J
AU Jelacic, TM
Chabot, DJ
Bozue, JA
Tobery, SA
West, MW
Moody, K
Yang, D
Oppenheim, JJ
Friedlander, AM
AF Jelacic, Tanya M.
Chabot, Donald J.
Bozue, Joel A.
Tobery, Steven A.
West, Michael W.
Moody, Krishna
Yang, De
Oppenheim, Joost J.
Friedlander, Arthur M.
TI Exposure to Bacillus anthracis Capsule Results in Suppression of Human
Monocyte-Derived Dendritic Cells
SO INFECTION AND IMMUNITY
LA English
DT Article
ID D-GLUTAMIC ACID; CHEMOKINE RECEPTOR; CHEMICAL BASIS; HOST-DEFENSE;
GUINEA-PIGS; VIVO FATE; IN-VIVO; PEPTIDOGLYCAN; VIRULENCE; ANTIGEN
AB The antiphagocytic capsule of Bacillus anthracis is a major virulence factor. We hypothesized that it may also mediate virulence through inhibition of the host's immune responses. During an infection, the capsule exists attached to the bacterial surface but also free in the host tissues. We sought to examine the impact of free capsule by assessing its effects on human monocytes and immature dendritic cells (iDCs). Human monocytes were differentiated into iDCs by interleukin-4 (IL-4) and granulocyte-macrophage colony-stimulating factor (GM-CSF) over 7 days in the presence of capsule derived from wild-type encapsulated B. anthracis Ames (WT) or a control preparation from an isogenic B. anthracis Ames strain that produces only 2% of the capsule of the WT (capA mutant). WT capsule consistently induced release of IL-8 and IL-6 while the capA mutant control preparation elicited either no response or only a minimal release of IL-8. iDCs that were differentiated in the presence of WT capsule had increased side scatter (SSC), a measure of cellular complexity, when assessed by flow cytometry. iDCs differentiated in the presence of WT capsule also matured less well in response to subsequent B. anthracis peptidoglycan (Ba PGN) exposure, with reduced upregulation of the chemokine receptor CCR7, reduced CCR7-dependent chemotaxis, and reduced release of certain cytokines. Exposure of naive differentiated control iDCs to WT capsule did not alter cell surface marker expression but did elicit IL-8. These results indicate that free capsule may contribute to the pathogenesis of anthrax by suppressing the responses of immune cells and interfering with the maturation of iDCs.
C1 [Jelacic, Tanya M.; Chabot, Donald J.; Bozue, Joel A.; Tobery, Steven A.; West, Michael W.; Friedlander, Arthur M.] US Army Med Res Inst Infect Dis, Frederick, MD 21702 USA.
[Yang, De; Oppenheim, Joost J.] Frederick Natl Lab Canc Res, Mol Immunoregulat Lab, Frederick, MD USA.
[Moody, Krishna] Boston Univ, Sch Med, Dept Microbiol, Boston, MA 02118 USA.
RP Jelacic, TM (reprint author), US Army Med Res Inst Infect Dis, Frederick, MD 21702 USA.
EM tanya.obreiter@us.army.mil; arthur.friedlander@us.army.mil
FU Defense Threat Reduction Agency [CBM.VAXBT.03.10.RD.015]
FX The work was supported by the Defense Threat Reduction Agency grant
CBM.VAXBT.03.10.RD.015.
NR 47
TC 4
Z9 4
U1 4
U2 9
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0019-9567
EI 1098-5522
J9 INFECT IMMUN
JI Infect. Immun.
PD AUG
PY 2014
VL 82
IS 8
BP 3405
EP 3416
DI 10.1128/IAI.01857-14
PG 12
WC Immunology; Infectious Diseases
SC Immunology; Infectious Diseases
GA AL5GK
UT WOS:000339161400029
PM 24891109
ER
PT J
AU Liu, HN
Zhang, Y
Chen, YP
Wijewarnasuriya, PS
AF Liu, Henan
Zhang, Yong
Chen, Yuanping
Wijewarnasuriya, Priyalal S.
TI Confocal Micro-PL Mapping of Defects in CdTe Epilayers Grown on Si (211)
Substrates with Different Annealing Cycles
SO JOURNAL OF ELECTRONIC MATERIALS
LA English
DT Article
DE CdTe; mu-PL; defects; EPD
ID MOLECULAR-BEAM EPITAXY; PHOTOLUMINESCENCE; FILMS
AB We have applied confocal microphotoluminescence (mu-PL) microscopy to investigate the effects of extended defects in CdTe epilayers grown on (211) Si substrates with different numbers of annealing cycles N. Our results show that the PL dark spot density (PL-DSD) decreases while the spatially averaged PL intensity increases with increasing number of annealing cycles. This is consistent with the general trend that an increase in the number of annealing cycles leads to a reduction of the x-ray diffraction linewidth and etch pit density (EPD). However, direct comparison between the etch pits, imaged by scanning electron microscopy, and PL dark spots on the same sample area results in two important observations: (1) the PL-DSD is substantially higher than the EPD, and (2) not all etch pits appear as dark spots in PL maps. These findings suggest that PL mapping is a more sensitive technique for revealing the extended defects that are actually detrimental to photogenerated carriers, in addition to the apparent advantages of being noninvasive and more efficient.
C1 [Liu, Henan; Zhang, Yong] Univ N Carolina, Charlotte, NC 28223 USA.
[Chen, Yuanping; Wijewarnasuriya, Priyalal S.] US Army Res Lab, Adelphi, MD USA.
RP Liu, HN (reprint author), Univ N Carolina, Charlotte, NC 28223 USA.
EM yong.zhang@uncc.edu
RI Zhang, Yong/D-3412-2013
FU DARPA/MTO [W911NF-11-2-0070]; Bissell Distinguished Professorship
FX This project was supported by DARPA/MTO under Contract #
W911NF-11-2-0070, which was monitored by Dr. Nibir Dhar. Yong Zhang
acknowledges the support of the Bissell Distinguished Professorship.
NR 10
TC 0
Z9 0
U1 2
U2 17
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0361-5235
EI 1543-186X
J9 J ELECTRON MATER
JI J. Electron. Mater.
PD AUG
PY 2014
VL 43
IS 8
BP 2854
EP 2859
DI 10.1007/s11664-014-3129-y
PG 6
WC Engineering, Electrical & Electronic; Materials Science,
Multidisciplinary; Physics, Applied
SC Engineering; Materials Science; Physics
GA AL7SH
UT WOS:000339334800013
ER
PT J
AU Shishehchi, S
Garrett, GA
Rudin, S
Wraback, M
Bellotti, E
AF Shishehchi, Sara
Garrett, Gregory A.
Rudin, Sergey
Wraback, Michael
Bellotti, Enrico
TI Theoretical and Experimental Study of Time- and Temperature-Dependent
Photoluminescence in ZnO
SO JOURNAL OF ELECTRONIC MATERIALS
LA English
DT Article
DE Photo-excited carriers; Monte Carlo simulation; ZnO; time-resolved
photo-luminescence
ID MONTE-CARLO-SIMULATION; PHOTOEXCITED SEMICONDUCTORS; ULTRAFAST
RELAXATION; CARRIER DYNAMICS; COHERENT; LUMINESCENCE; GENERATION;
TRANSPORT; ELECTRON; GAAS
AB In this work, we investigate the dynamics of photo-excited carriers in ZnO. Specifically, we study the luminescence spectrum and the effect of temperature on the luminescence rise time. For comparison, experimental time- resolved photo-luminescence studies on ZnO samples are performed. In the theoretical model, interaction with a laser pulse is treated coherently and a generalized Monte Carlo simulation is used to account for scattering processes. The scattering mechanisms included are carrier interactions with polar optical phonons and acoustic phonons, and carrier-carrier Coulomb interactions. We observed a good agreement between the experimental and simulation results for the photo-luminescence spectrum. Furthermore, as the temperature increases, the luminescence rise time decreases, mostly due to the weaker effect of polar optical scattering at lower temperature.
C1 [Shishehchi, Sara; Bellotti, Enrico] Boston Univ, Dept Elect & Comp Engn, Boston, MA 02215 USA.
[Garrett, Gregory A.; Rudin, Sergey; Wraback, Michael] US Army Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD USA.
RP Shishehchi, S (reprint author), Boston Univ, Dept Elect & Comp Engn, 8 St Marys St, Boston, MA 02215 USA.
EM bellotti@bu.edu
FU U.S. Army Research Laboratory through the Collaborative Research
Alliance (CRA) for MultiScale multidisciplinary Modeling of Electronic
materials (MSME)
FX The work at Boston University has been supported by the U.S. Army
Research Laboratory through the Collaborative Research Alliance (CRA)
for MultiScale multidisciplinary Modeling of Electronic materials
(MSME).
NR 22
TC 0
Z9 0
U1 3
U2 23
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0361-5235
EI 1543-186X
J9 J ELECTRON MATER
JI J. Electron. Mater.
PD AUG
PY 2014
VL 43
IS 8
BP 3033
EP 3040
DI 10.1007/s11664-014-3188-0
PG 8
WC Engineering, Electrical & Electronic; Materials Science,
Multidisciplinary; Physics, Applied
SC Engineering; Materials Science; Physics
GA AL7SH
UT WOS:000339334800037
ER
PT J
AU Peiris, FC
Brill, G
Doyle, K
VanMil, B
Myers, TH
AF Peiris, F. C.
Brill, G.
Doyle, Kevin
VanMil, Brenda
Myers, Thomas H.
TI Exploring the Optical Properties of Hg1-x Cd-x Se Films Using
IR-Spectroscopic Ellipsometry
SO JOURNAL OF ELECTRONIC MATERIALS
LA English
DT Article
DE HgCdSe; ellipsometry; dielectric function; doping
AB We have used infrared spectroscopic ellipsometry to interrogate the dielectric response of a series of Hg1-x Cd (x) Se samples in a spectral range between 2000 and 40000 nm. Using a standard inversion technique, the experimental data obtained at multiple angles of incidence were modeled to deduce the dielectric function of each sample. The dielectric functions obtained for Hg1-x Cd (x) Se samples allowed us to predict the band gaps for the samples, which increase as a function of the Cd concentration. Next, we modeled the dielectric function as a collection of oscillators, each of which represented a particular transition manifested in the spectrum. The most significant result obtained from this work is the recovery of their doping characteristics from the ellipsometric data. Specifically, two Hg1-x Cd (x) Se samples with x = 0.21 and 0.28, grown on GaSb substrates, show a carrier concentration of 1.6 x 10(17) and 1.8 x 10(18) cm(-3), respectively. These results are particularly helpful because conventional Hall measurements cannot be used for these specific samples due to the substrates (i.e., GaSb) used to grow them being highly conductive.
C1 [Peiris, F. C.] Kenyon Coll, Dept Phys, Gambier, OH 43022 USA.
[Brill, G.; Doyle, Kevin; VanMil, Brenda] US Army Res Lab, Adelphi, MD 20783 USA.
[Myers, Thomas H.] Texas State Univ San Marcos, Dept Phys, San Marcos, TX 78666 USA.
RP Peiris, FC (reprint author), Kenyon Coll, Dept Phys, Gambier, OH 43022 USA.
EM peirisf@kenyon.edu
RI Myers, Thomas/C-3769-2013
FU National Science Foundation [DMR-1207169]; U.S. Army Research
Laboratory; U.S. Army Research Office [W911NF-10-2-0103,
W911NF-10-1-0335, W911NF-12-2-0019]
FX The work at Kenyon was funded by the National Science Foundation
DMR-1207169 grant. Support for the growth and study of the
Hg1-xCdxSe samples was provided by the U.S. Army
Research Laboratory and the U.S. Army Research Office under
contract/grant numbers W911NF-10-2-0103, W911NF-10-1-0335, and
W911NF-12-2-0019.
NR 13
TC 2
Z9 3
U1 2
U2 9
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0361-5235
EI 1543-186X
J9 J ELECTRON MATER
JI J. Electron. Mater.
PD AUG
PY 2014
VL 43
IS 8
BP 3056
EP 3059
DI 10.1007/s11664-014-3208-0
PG 4
WC Engineering, Electrical & Electronic; Materials Science,
Multidisciplinary; Physics, Applied
SC Engineering; Materials Science; Physics
GA AL7SH
UT WOS:000339334800040
ER
PT J
AU Jayakumar, P
Melanz, D
MacLennan, J
Gorsich, D
Senatore, C
Iagnemma, K
AF Jayakumar, Paramsothy
Melanz, Daniel
MacLennan, Jamie
Gorsich, David
Senatore, Carmine
Iagnemma, Karl
TI Scalability of classical terramechanics models for lightweight vehicle
applications incorporating stochastic modeling and uncertainty
propagation
SO JOURNAL OF TERRAMECHANICS
LA English
DT Article
DE Terramechanics; Robotic vehicles; Bekker and Wong models; Soil test bed;
Uncertainty propagation; Stochastic modeling
ID TERRAIN
AB This paper investigates the validity of commonly used terramechanics models for lightweight vehicle applications while accounting for experimental variability. This is accomplished by cascading uncertainty up to the point of wheel performance. Vehicle-terrain interaction is extremely complex, and thus models and simulation methods for vehicle mobility prediction are largely based on empirical data. Analytical methods are compared to experimental measurements of key operational parameters such as drawbar force, torque, and sinkage. Models of operational parameters ultimately depend on a small set of empirically determined soil parameters, each with an inherent uncertainty due to test variability. The soil parameters associated with normal loads are determined by fitting the dimensionless form of Bekker's equation to the pressure-sinkage test data. Similarly, the soil parameters associated with shear loads are determined by fitting Janosi-Hanamoto's equation to the direct shear test data. An uncertainty model is used to propagate the soil parameter variability through to the wheel performance based on Wong and Reece. This commonly used analytical model is shown to be inaccurate as the envelope of model uncertainty does not lie within the experimental measures, suggesting that model improvements are required to accurately predict the performance of lightweight vehicles on deformable terrain. Published by Elsevier Ltd. on behalf of ISTVS.
C1 [Jayakumar, Paramsothy; Melanz, Daniel; MacLennan, Jamie; Gorsich, David] US Army TARDEC, Warren, MI 48092 USA.
[Senatore, Carmine; Iagnemma, Karl] MIT, Cambridge, MA 02139 USA.
RP Jayakumar, P (reprint author), US Army TARDEC, Warren, MI 48092 USA.
EM Paramsothy.Jayakumar.civ@mail.mil
NR 20
TC 2
Z9 3
U1 2
U2 8
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0022-4898
EI 1879-1204
J9 J TERRAMECHANICS
JI J. Terramech.
PD AUG
PY 2014
VL 54
BP 37
EP 57
DI 10.1016/j.jterra.2014.04.004
PG 21
WC Engineering, Environmental
SC Engineering
GA AL6CQ
UT WOS:000339220300003
ER
PT J
AU Drost, RJ
Sadler, BM
AF Drost, Robert J.
Sadler, Brian M.
TI Survey of ultraviolet non-line-of-sight communications
SO SEMICONDUCTOR SCIENCE AND TECHNOLOGY
LA English
DT Article
DE ultraviolet; communications; non-line-of-sight; free-space optical
communications
ID SCATTER PROPAGATION MODEL; SOLAR-BLIND; NONCOPLANAR GEOMETRY; UV
COMMUNICATION; PATH LOSS; RANGE; PERFORMANCE; RADIATION; CHANNELS;
NETWORK
AB The unique characteristics of the atmospheric propagation of deep ultraviolet (UV) radiation make possible the novel capability of establishing non-line-of-sight (NLOS) optical communication links. Although NLOS UV communications (UVC) has been studied for decades, early work focused on the use of lasers and flash lamps as sources. Recent advances in device technology, including UV light-emitting diodes and solar-blind optical filters, suggest that compact low-power systems may soon be feasible, and, as a result, research into the effective use of this rapidly maturing technology has accelerated. In this paper, we review the NLOS UVC literature, examining a range of topics from channel modelling and experimentation through system analysis and prototype development. The breadth of this research not only indicates the growing interest in UVC technology but also suggests the existence of many avenues for continued exploration.
C1 [Drost, Robert J.; Sadler, Brian M.] Army Res Lab, Adelphi, MD 20783 USA.
RP Drost, RJ (reprint author), Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA.
EM robert.j.drost6.civ@mail.mil
NR 57
TC 12
Z9 13
U1 4
U2 33
PU IOP PUBLISHING LTD
PI BRISTOL
PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND
SN 0268-1242
EI 1361-6641
J9 SEMICOND SCI TECH
JI Semicond. Sci. Technol.
PD AUG
PY 2014
VL 29
IS 8
AR 084006
DI 10.1088/0268-1242/29/8/084006
PG 11
WC Engineering, Electrical & Electronic; Materials Science,
Multidisciplinary; Physics, Condensed Matter
SC Engineering; Materials Science; Physics
GA AL6LE
UT WOS:000339243300009
ER
PT J
AU Shatalov, M
Sun, WH
Jain, R
Lunev, A
Hu, XH
Dobrinsky, A
Bilenko, Y
Yang, JW
Garrett, GA
Rodak, LE
Wraback, M
Shur, M
Gaska, R
AF Shatalov, Max
Sun, Wenhong
Jain, Rakesh
Lunev, Alex
Hu, Xuhong
Dobrinsky, Alex
Bilenko, Yuri
Yang, Jinwei
Garrett, Gregory A.
Rodak, Lee E.
Wraback, Michael
Shur, Michael
Gaska, Remis
TI High power AlGaN ultraviolet light emitters
SO SEMICONDUCTOR SCIENCE AND TECHNOLOGY
LA English
DT Article
DE ultraviolet; nitrides; light-emitting diodes; semiconductor; quantum
wells
ID ALN; DISLOCATIONS
AB We present the analysis of the external quantum efficiency in AlGaN deep ultraviolet (DUV) light-emitting diodes (LEDs) on sapphire substrates and discuss factors affecting the output power of DUV LEDs. Performance of the LED is related to optimization of the device structure design and improvements of the epitaxial material quality.
C1 [Shatalov, Max; Sun, Wenhong; Jain, Rakesh; Lunev, Alex; Hu, Xuhong; Dobrinsky, Alex; Bilenko, Yuri; Yang, Jinwei; Gaska, Remis] Sensor Elect Technol Inc, Columbia, SC 29209 USA.
[Garrett, Gregory A.; Rodak, Lee E.; Wraback, Michael] US Army, Res Lab, Adelphi, MD 20783 USA.
[Shur, Michael] Rensselaer Polytech Inst, Dept Elect Comp & Syst Engn, Troy, NY 12180 USA.
[Shur, Michael] Rensselaer Polytech Inst, Ctr Integrated Elect, Troy, NY 12180 USA.
RP Shatalov, M (reprint author), Sensor Elect Technol Inc, 1195 Atlas Rd, Columbia, SC 29209 USA.
EM shatalov@s-et.com
RI Shur, Michael/A-4374-2016
OI Shur, Michael/0000-0003-0976-6232
FU DARPA CMUVT program; Army Research Laboratory under ARL MSME Alliance
FX This work was partially supported by the DARPA CMUVT program monitored
by Dr D Green. The work at RPI was also partially supported by the Army
Research Laboratory under ARL MSME Alliance (Project Monitor Dr Meredith
Reed).
NR 29
TC 41
Z9 41
U1 6
U2 47
PU IOP PUBLISHING LTD
PI BRISTOL
PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND
SN 0268-1242
EI 1361-6641
J9 SEMICOND SCI TECH
JI Semicond. Sci. Technol.
PD AUG
PY 2014
VL 29
IS 8
AR 084007
DI 10.1088/0268-1242/29/8/084007
PG 6
WC Engineering, Electrical & Electronic; Materials Science,
Multidisciplinary; Physics, Condensed Matter
SC Engineering; Materials Science; Physics
GA AL6LE
UT WOS:000339243300010
ER
PT J
AU Nadler, R
Convertino, VA
Gendler, S
Lending, G
Lipsky, AM
Cardin, S
Lowenthal, A
Glassberg, E
AF Nadler, Roy
Convertino, Victor A.
Gendler, Sami
Lending, Gadi
Lipsky, Ari M.
Cardin, Sylvain
Lowenthal, Alexander
Glassberg, Elon
TI THE VALUE OF NONINVASIVE MEASUREMENT OF THE COMPENSATORY RESERVE INDEX
IN MONITORING AND TRIAGE OF PATIENTS EXPERIENCING MINIMAL BLOOD LOSS
SO SHOCK
LA English
DT Article
DE Compensatory reserve index; prehospital; triage; hemorrhage
ID HEART-RATE-VARIABILITY; COMBAT CASUALTY CARE; EN-ROUTE CARE; CENTRAL
HYPOVOLEMIA; SHOCK INDEX; TRAUMA; MORTALITY; MILITARY; TOOL
AB Currently available triage and monitoring tools are often late to detect life-threatening clinically significant physiological aberrations and provide limited data in prioritizing bleeding patients for treatment and evacuation. The Compensatory Reserve Index (CRI) is a novel means of assessing physiologic reserve, shown to correlate with central blood volume loss under laboratory conditions. The purpose of this study was to compare the noninvasive CRI device with currently available vital signs in detecting blood loss. Study subjects were soldiers volunteering for blood donation (n = 230), and the control group was composed of soldiers who did not donate blood (n = 34). Data collected before and after blood donation were compared, receiver operator characteristic curves were generated after either donation or the appropriate time interval, and areas under the curves (AUCs) were compared. Compared with pre-blood loss, blood donation resulted in a mean reduction of systolic blood pressure by 3% (before, 123 mmHg; after, 119 mmHg; P < 0.01). The CRI demonstrated a 16% reduction (before, 0.74; after, 0.62; P < 0.01). Heart rate, diastolic blood pressure, and oxygen saturation remained unchanged. The AUC for change in CRI was 0.81, 0.56 for change in heart rate, 0.53 for change in systolic blood pressure, 0.55 and 0.58 for pulse pressure and shock index, respectively. The AUCs for detecting mild blood loss at a single measurement were 0.73 for heart rate, 0.60 for systolic blood pressure, 0.62 for diastolic blood pressure, 0.45 for pulse oximetry, and 0.84 for CRI. The CRI was better than standard indices in detecting mild blood loss. Single measurement of CRI may enable a more accurate triage, and CRI monitoring may allow for earlier detection of casualty deterioration.
C1 [Nadler, Roy; Gendler, Sami; Lending, Gadi; Lipsky, Ari M.; Glassberg, Elon] Israeli Def Forces, Trauma & Combat Med Branch, Surg Gen Headquarters, Ramat Gan, Israel.
[Convertino, Victor A.; Cardin, Sylvain] US Army Inst Surg Res, Ft Sam Houston, TX USA.
[Lipsky, Ari M.] Rambam Hlth Care Campus, Dept Emergency Med, Haifa, Israel.
[Lowenthal, Alexander] Schneider Childrens Med Ctr Israel, Dept Pediat Cardiol, Petah Tiqwa, Israel.
RP Glassberg, E (reprint author), Israeli Def Forces, Trauma & Combat Med Branch, Med Corps, Surg Gen Headquarters, Mil POB 02149, Ramat Gan, Israel.
EM idf_trauma@idf.gov.il
NR 26
TC 11
Z9 11
U1 0
U2 9
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1073-2322
EI 1540-0514
J9 SHOCK
JI Shock
PD AUG
PY 2014
VL 42
IS 2
BP 93
EP 98
DI 10.1097/SHK.0000000000000178
PG 6
WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease
SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System
& Cardiology
GA AL6MB
UT WOS:000339245700003
PM 24667628
ER
PT J
AU Liu, NT
Holcomb, JB
Wade, CE
Darrah, MI
Salinas, J
AF Liu, Nehemiah T.
Holcomb, John B.
Wade, Charles E.
Darrah, Mark I.
Salinas, Jose
TI UTILITY OF VITAL SIGNS, HEART RATE VARIABILITY AND COMPLEXITY, AND
MACHINE LEARNING FOR IDENTIFYING THE NEED FOR LIFESAVING INTERVENTIONS
IN TRAUMA PATIENTS
SO SHOCK
LA English
DT Article
DE Machine learning; lifesaving interventions; heart rate complexity; heart
rate variability; trauma
ID SAMPLE ENTROPY; PREDICTION; SHOCK; HELICOPTERS; OUTCOMES; TRIAGE;
IMPACT; NOISE
AB To date, no studies have attempted to utilize data from a combination of vital signs, heart rate variability and complexity (HRV, HRC), as well as machine learning (ML), for identifying the need for lifesaving interventions (LSIs) in trauma patients. The objectives of this study were to examine the utility of the above for identifying LSI needs and compare different LSI-associated models, with the hypothesis that an ML model would be superior in performance over multivariate logistic regression models. One hundred four patients transported from the injury scene via helicopter were selected for the study. A wireless vital signs monitor was attached to the patient's arm and used to capture physiologic data, including HRV and HRC. The power of vital sign measurements, HRV, HRC, and Glasgow Coma Scale score (GCS) to identify patients requiring LSIs was estimated using multivariate logistic regression and ML. Receiver operating characteristic (ROC) curves were also obtained. Thirty-two patients underwent 75 LSIs. After logistic regression, ROC curves demonstrated better identification for LSIs using heart rate (HR) and HRC (area under the curve [AUC] of 0.81) than using HR alone (AUC of 0.73). Likewise, ROC curves demonstrated better identification for LSIs using GCS and HRC (AUC of 0.94) than using GCS and HR (AUC of 0.92). Importantly, ROC curves demonstrated that an ML model using HR, GCS, and HRC (AUC of 0.99) had superior performance over multivariate logistic regression models for identifying the need for LSIs in trauma patients. Development of computer decision support systems should utilize vital signs, HRC, and ML in order to achieve more accurate diagnostic capabilities, such as identification of needs for LSIs in trauma patients.
C1 [Liu, Nehemiah T.; Salinas, Jose] US Army Inst Surg Res, Ft Sam Houston, TX USA.
[Holcomb, John B.; Wade, Charles E.] Univ Texas Hlth Sci Ctr Houston, Ctr Translat Injury Res, Dept Surg, Houston, TX 77030 USA.
[Darrah, Mark I.] Athena GTX Inc, Des Moines, IA USA.
RP Liu, NT (reprint author), US Army Inst Surg Res, 3698 Chambers Pass, Jbsa Ft Sam Houston, TX 78234 USA.
EM nehemiah.liu@us.army.mil
FU National Trauma Institute; Combat Casualty Care Research Program; State
of Texas Emerging Technology Fund
FX This work was supported by the National Trauma Institute, the Combat
Casualty Care Research Program, and the State of Texas Emerging
Technology Fund.
NR 30
TC 9
Z9 10
U1 0
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1073-2322
EI 1540-0514
J9 SHOCK
JI Shock
PD AUG
PY 2014
VL 42
IS 2
BP 108
EP 114
DI 10.1097/SHK.0000000000000186
PG 7
WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease
SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System
& Cardiology
GA AL6MB
UT WOS:000339245700005
PM 24727872
ER
PT J
AU Rani, M
Zhang, Q
Schwacha, MG
AF Rani, Meenakshi
Zhang, Qiong
Schwacha, Martin G.
TI GAMMA DELTA T CELLS REGULATE WOUND MYELOID CELL ACTIVITY AFTER BURN
SO SHOCK
LA English
DT Article
DE Injury; inflammation; macrophage; MDSC; cytokines
ID SYSTEMIC INFLAMMATORY RESPONSE; THERMAL-INJURY; SUPPRESSOR-CELLS;
IMMUNE-SYSTEM; MACROPHAGE HYPERACTIVITY; UP-REGULATION; MURINE MODEL;
IMMUNOSUPPRESSION; LYMPHOCYTES; DYSFUNCTION
AB Major burns induce immune complications, which are associated with myeloid cell activation by ill-defined mechanisms. Although gamma delta T cells have been shown to be important in postinjury inflammation and wound healing, their role in the regulation of myeloid cells remains unknown. To study this, wild-type (WT) and gamma delta T cell-deficient (delta TCR-/-) mice were subjected to major burn (25% total body surface area, third degree) or sham treatment. At 3 days thereafter, skin samples were assayed for cytokine content or used to isolate single cells that were used for myeloid cell characterization by flow cytometry. The number of CD11b(+) myeloid cells increased by approximately 75% in the wound skin of WT mice. This influx was caused by increased myeloid-derived suppressor cells (CD11b(+) GR1(+)) whose numbers increased 19-fold compared with those of sham skin. In contrast, macrophage (MO; CD11b(+) F4/80(+)) numbers decreased by approximately 50% after burn. In delta TCR-/- mice, burn increased the myeloid cell numbers approximately 5-fold. The increase in myeloid cells at the injury site of delta TCR-/- mice was caused by both a myeloid-derived suppressor cell (50-fold) and a MO (2-fold) influx. Burn increased skin cytokine levels for a number of prototypic inflammatory cytokines (interleukin 1 beta, interleukin 6, tumor necrosis factor-alpha, macrophage inflammatory protein [MIP] 1 beta, etc). Tumor necrosis factor-alpha, MIP-alpha, and MIP-1 beta levels were further elevated (2- to 3-fold) in the injured skin of delta TCR-/- mice compared with those of WT mice. In conclusion, these data show that gamma delta T cells regulate myeloid cell infiltration of the wound site and act to quell inflammation, thereby promoting the transition to the proliferative phase of wound healing.
C1 [Rani, Meenakshi; Zhang, Qiong; Schwacha, Martin G.] Univ Texas Hlth Sci Ctr San Antonio, Dept Surg, San Antonio, TX 78229 USA.
[Schwacha, Martin G.] US Army Inst Surg Res, Ft Sam Houston, TX USA.
RP Schwacha, MG (reprint author), Univ Texas Hlth Sci Ctr San Antonio, Dept Surg, Mail Code 7740,7703 Floyd Curl Dr, San Antonio, TX 78229 USA.
EM schwacha@uthscsa.edu
FU National Institutes of Health [GM079122]
FX This study was supported by the National Institutes of Health (grant no.
GM079122).
NR 43
TC 8
Z9 9
U1 2
U2 10
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1073-2322
EI 1540-0514
J9 SHOCK
JI Shock
PD AUG
PY 2014
VL 42
IS 2
BP 133
EP 141
DI 10.1097/SHK.0000000000000176
PG 9
WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease
SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System
& Cardiology
GA AL6MB
UT WOS:000339245700009
PM 24667623
ER
PT J
AU Qiao, L
Hong, Y
McPherson, R
Shafer, M
Gade, D
Williams, D
Chen, S
Lilly, D
AF Qiao, Lei
Hong, Yang
McPherson, Renee
Shafer, Mark
Gade, David
Williams, David
Chen, Sheng
Lilly, Douglas
TI Climate Change and Hydrological Response in the Trans-State Oologah Lake
Watershed-Evaluating Dynamically Downscaled NARCCAP and Statistically
Downscaled CMIP3 Simulations with VIC Model
SO WATER RESOURCES MANAGEMENT
LA English
DT Article
DE Climate change; NARCCAP; Statistical downscaling; VIC; Oologah Lake
watershed
ID SOIL-MOISTURE; UNITED-STATES; RIVER-BASIN; PARAMETERIZATION;
PRECIPITATION; PERFORMANCE; SCHEMES; IMPACTS; PROJECT; RUNOFF
AB Statistically and dynamically downscaled climate projections are the two important data sources for evaluation of climate change and its impact on water availability, water quality and ecosystems. Though bias correction helps to adjust the climate model output to behave more similarly to observations, the hydrologic response still can be biased. This study uses Variable Infiltration Capacity (VIC) model to evaluate the hydrologic response of the trans-state Oologah Lake watershed to climate change by using both statistically and dynamically downscaled multiple climate projections. Simulated historical and projected climate data from the North American Regional Climate Change Assessment Program (NARCCAP) and Bias-Corrected and Spatially Downscaled-Coupled Model Intercomparison Phase 3 (BCSD-CMIP3) forced the hydrologic model. In addition, different river network upscaling methods are also compared for a higher VIC model performance. Evaluation and comparison shows the following the results. (1) From the hydrologic point of view, the dynamically downscaled NARCCAP projection performed better, most likely in capturing a larger portion of mesoscale-driven convective rainfall than the statistically downscaled CMIP3 projections; hence, the VIC model generated higher seasonal streamflow amplitudes that are closer to observations. Additionally, the statistically downscaled GCMs are less likely to capture the hydrological simulation probably due to missing integration of climate variables of wind, solar radiation and others, even though their precipitation and temperature are bias corrected to be more favorably than the NARCCAP simulations. (2) Future water availability (precipitation, runoff, and baseflow) in the watershed would increase annually by 3-4 %, suggested by both NARCCAP and BCSD-CMIP3. Temperature increases (2.5-3 degrees C) are much more consistent between the two types of climate projections both seasonally and annually. However, NARCCAP suggested 2-3 times higher seasonal variability of precipitation and other water fluxes than the BCSD-CMIP3 models. (3) The hydrologic performance could be used as a potential metric to comparatively differentiate climate models, since the land surface and atmosphere processes are considered integrally.
C1 [Qiao, Lei; Hong, Yang; Chen, Sheng] Univ Oklahoma, Sch Civil Engn & Environm Sci, Norman, OK 73019 USA.
[Qiao, Lei; Hong, Yang; Chen, Sheng] Univ Oklahoma, Adv Radar Res Ctr, Norman, OK 73019 USA.
[Qiao, Lei] Oklahoma State Univ, Dept Nat Resource Ecol & Management, Stillwater, OK 74078 USA.
[McPherson, Renee; Shafer, Mark] Univ Oklahoma, Oklahoma Climatol Survey, Norman, OK 73019 USA.
[McPherson, Renee; Shafer, Mark] Univ Oklahoma, Dept Geog & Environm Sustainabil, Norman, OK 73019 USA.
[Gade, David; Williams, David; Lilly, Douglas] US Army Corps Engineers, Tulsa Dist, OK USA.
[Hong, Yang] Tsinghua Univ, Dept Hydraul Engn, Beijing 100084, Peoples R China.
[Hong, Yang] Natl Weather Ctr, Adv Radar Res Ctr, Hydrometeorol & Remote Sensing Lab Hydro Ou Edu, Norman, OK 73072 USA.
RP Hong, Y (reprint author), Natl Weather Ctr, Adv Radar Res Ctr, Hydrometeorol & Remote Sensing Lab Hydro Ou Edu, Suite 4610,120 David L Boren Blvd, Norman, OK 73072 USA.
EM yanghong@ou.edu
RI McPherson, Renee/H-6256-2016; Hong, Yang/D-5132-2009
OI McPherson, Renee/0000-0002-1497-9681; Hong, Yang/0000-0001-8720-242X
FU Responses to Climate Change program; U.S. Army Corps of Engineers
Institute for Water Resources; South Central Climate Science Center;
U.S. Geological Survey
FX This research was funded by the Responses to Climate Change program,
U.S. Army Corps of Engineers Institute for Water Resources and the South
Central Climate Science Center, U.S. Geological Survey. We wish to thank
the North American Regional Climate Change Assessment Program (NARCCAP)
for providing the data used in this paper. "Bias Corrected and
Downscaled WCRP CMIP3 Climate Projections" archive at
http://gdo-dcp.ucllnl.org/downscaled_cmip3_ projections/.
NR 47
TC 10
Z9 10
U1 4
U2 28
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0920-4741
EI 1573-1650
J9 WATER RESOUR MANAG
JI Water Resour. Manag.
PD AUG
PY 2014
VL 28
IS 10
BP 3291
EP 3305
DI 10.1007/s11269-014-0678-z
PG 15
WC Engineering, Civil; Water Resources
SC Engineering; Water Resources
GA AK8BC
UT WOS:000338651100035
ER
PT J
AU Tarney, CM
Wilson, K
Sewell, MF
AF Tarney, Christopher M.
Wilson, Karen
Sewell, Mark F.
TI Cogan Syndrome in Pregnancy
SO OBSTETRICS AND GYNECOLOGY
LA English
DT Article
AB BACKGROUND: Cogan syndrome is a rare, multisystem, autoimmune disorder of unknown etiology. Little is known about whether it affects pregnancy or whether pregnancy affects the disease.
CASE: A 24-year-old primigravid woman with Cogan syndrome diagnosed 3 years before her pregnancy presented to our clinic for prenatal care. During pregnancy she experienced no worsening of symptoms of her disease but reported subjective improvement in vision and hearing. Cesarean delivery was performed at term because of nonreassuring fetal status. There were no obstetric or postpartum complications.
CONCLUSION: Cogan syndrome requires close monitoring. If it worsens, then the disease process can be similar to both physiologic and pathologic changes of pregnancy. However, unlike the former, worsening Cogan syndrome can have irreversible maternal consequences.
C1 [Tarney, Christopher M.] Womack Army Med Ctr, Dept Obstet & Gynecol, 2817 Reilly Rd, Ft Bragg, NC 28307 USA.
Womack Army Med Ctr, Dept Obstet & Gynecol, Div Maternal Fetal Med, Ft Bragg, NC 28307 USA.
RP Tarney, CM (reprint author), Womack Army Med Ctr, Dept Obstet & Gynecol, 2817 Reilly Rd, Ft Bragg, NC 28307 USA.
EM christopher.tarney@us.army.mil
NR 9
TC 2
Z9 2
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0029-7844
J9 OBSTET GYNECOL
JI Obstet. Gynecol.
PD AUG
PY 2014
VL 124
IS 2
SU 1
BP 428
EP 431
DI 10.1097/AOG.0000000000000390
PN 2
PG 5
WC Obstetrics & Gynecology
SC Obstetrics & Gynecology
GA V42GI
UT WOS:000209601900008
PM 25004327
ER
PT J
AU Hearn, AR
Chapman, ED
Singer, GP
Brostoff, WN
LaCivita, PE
Klimley, AP
AF Hearn, Alex R.
Chapman, Eric D.
Singer, Gabriel P.
Brostoff, William N.
LaCivita, Peter E.
Klimley, A. Peter
TI Movements of out-migrating late-fall run Chinook salmon (Oncorhynchus
tshawytscha) smolts through the San Francisco Bay Estuary
SO ENVIRONMENTAL BIOLOGY OF FISHES
LA English
DT Article
DE Acoustic tags; Telemetry; Chinook salmon; Tidal flows; Migration;
Sacramento River; San Francisco Bay Estuary
ID CENTRAL VALLEY; JUVENILE SALMONIDS; RIVER ESTUARY; CALIFORNIA; SURVIVAL;
HATCHERY; ECOLOGY; MYKISS; GROWTH; DELTA
AB One thousand late-fall run Chinook salmon (Oncorhynchus tshawytscha) hatchery reared smolts were fitted with ultrasonic coded tags over a two-year period (in 2009 and 2010) and released in the Sacramento River. We tracked their outmigration movements from Benicia Bridge to the Golden Gate. Smolts transited the Bay rapidly in 2 to 4 days, yet also made repeated upstream movements, coinciding with incoming tidal flows. Most smolts were detected in deep, channelized portions of the Bay. Some smolts were detected at nearshore, shallow sites such as marinas, or up tributaries, yet these fish generally returned to the main channel and continued their outmigration. The results suggest that the smolts perceive little benefit to remaining in estuarine waters, and therefore actively attempt to reach the ocean in as short a time as possible, rather than being transported passively by flows.
C1 [Hearn, Alex R.; Chapman, Eric D.; Singer, Gabriel P.; Klimley, A. Peter] Univ Calif Davis, Dept Wildlife Fish & Conservat Biol, Davis, CA 95616 USA.
[Brostoff, William N.; LaCivita, Peter E.] US Army Corps Engineers, San Francisco, CA 94103 USA.
RP Hearn, AR (reprint author), Univ Calif Davis, Dept Wildlife Fish & Conservat Biol, 1331,Acad Surge,1 Shields Ave, Davis, CA 95616 USA.
EM arhearn@ucdavis.edu
FU US Army Corps of Engineers, San Francisco District
FX This study was funded by the US Army Corps of Engineers, San Francisco
District, to provide information to the Long Term Management Strategy
(LTMS) for fish movement in San Francisco Bay relative to dredging and
dredged material placement operations. The authors would like to thank
Chuck Morton and Charlotte Cashin for scheduling boat time and assisting
on the Caltrans vessel with the maintenance of the monitors deployed on
the Bay Bridge and Richmond San Rafael Bridge. We appreciate the help
from everyone at the UC Davis Biotelemetry Laboratory (Mike Thomas,
Denise Tu, Michelle Buckhorn, Anna Steel and Jamilynn Poletto) for
volunteering their time to assist with the surgical implantation of the
tags and for assistance in maintaining the arrays. We would also like to
thank Arnold Ammann and Cyril Michel at the Santa Cruz office of the
NMFS for maintaining the database. Thanks to Kurt Brown and Kevin
Niemela at the Coleman National Fish Hatchery. All fish handling
protocols were approved under UC Davis Animal Care Protocol #15486.
NR 33
TC 2
Z9 2
U1 2
U2 24
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0378-1909
EI 1573-5133
J9 ENVIRON BIOL FISH
JI Environ. Biol. Fishes
PD AUG
PY 2014
VL 97
IS 8
BP 851
EP 863
DI 10.1007/s10641-013-0184-9
PG 13
WC Ecology; Marine & Freshwater Biology
SC Environmental Sciences & Ecology; Marine & Freshwater Biology
GA AK2EM
UT WOS:000338231900001
ER
PT J
AU Ferguson, JB
Lopez, HF
Rohatgi, PK
Cho, K
Kim, CS
AF Ferguson, J. B.
Lopez, Hugo F.
Rohatgi, Pradeep K.
Cho, Kyu
Kim, Chang-Soo
TI Impact of Volume Fraction and Size of Reinforcement Particles on the
Grain Size in Metal-Matrix Micro and Nanocomposites
SO METALLURGICAL AND MATERIALS TRANSACTIONS A-PHYSICAL METALLURGY AND
MATERIALS SCIENCE
LA English
DT Article
ID MECHANICAL-PROPERTIES; ALUMINUM-ALLOY; MG; STRENGTH; COMPOSITE;
MICROSTRUCTURE; BEHAVIOR; TENSILE; MMNCS
AB In metal-matrix micro and nanocomposites (MMCs and MMNCs), the presence and interactions of various strengthening mechanisms are not well understood, but grain boundary strengthening is considered as one of the primary means of improving the yield strength of composites. Owing to the importance of grain size on mechanical properties, it is necessary to be able to describe how incorporation of nanoparticles (NPs) in both powder metallurgy (PM) and solidification processing (SP) affects this critical property. In the present work, we provide a basis for an empirical equation that relates particle fraction and particle size to MMNC grain size for both PM and SP synthesis methods. The model suggests that NPs retard grain coarsening in PM MMNCs and also seems to describe the effect of reinforcement concentration on grain size in SP MMCs and MMNCs.
C1 [Ferguson, J. B.; Lopez, Hugo F.; Rohatgi, Pradeep K.; Kim, Chang-Soo] Univ Wisconsin, Mat Sci & Engn Dept, Milwaukee, WI 53211 USA.
[Cho, Kyu] US Army Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA.
RP Ferguson, JB (reprint author), Univ Wisconsin, Mat Sci & Engn Dept, Milwaukee, WI 53211 USA.
EM kimcs@uwm.edu
FU U.S. Army Research Laboratory [W911NF-08-2-0014]
FX This material is based upon work supported by the U.S. Army Research
Laboratory under Cooperative Agreement No. W911NF-08-2-0014. The views,
opinions, and conclusions made in this document are those of the authors
and should not be interpreted as representing the official policies,
either expressed or implied, of Army Research Laboratory or the U. S.
Government. The U. S. Government is authorized to reproduce and
distribute reprints for Government purposes notwithstanding any
copyright notation herein.
NR 21
TC 5
Z9 5
U1 2
U2 11
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1073-5623
EI 1543-1940
J9 METALL MATER TRANS A
JI Metall. Mater. Trans. A-Phys. Metall. Mater. Sci.
PD AUG
PY 2014
VL 45A
IS 9
BP 4055
EP 4061
DI 10.1007/s11661-014-2358-2
PG 7
WC Materials Science, Multidisciplinary; Metallurgy & Metallurgical
Engineering
SC Materials Science; Metallurgy & Metallurgical Engineering
GA AK2VM
UT WOS:000338277600036
ER
PT J
AU Zheng, ZL
Badawy, T
Henein, N
Sattler, E
Johnson, N
AF Zheng, Ziliang
Badawy, Tamer
Henein, Naeim
Sattler, Eric
Johnson, Nicholas
TI Effect of Cetane Improver on Autoignition Characteristics of Low Cetane
Sasol IPK Using Ignition Quality Tester
SO JOURNAL OF ENGINEERING FOR GAS TURBINES AND POWER-TRANSACTIONS OF THE
ASME
LA English
DT Article
ID FUEL; EMISSIONS; NUMBER
AB This paper investigates the effect of a cetane improver on the autoignition characteristics of Sasol IPK in the combustion chamber of the ignition quality tester (IQT). The fuel tested was Sasol IPK with a derived cetane number (DCN) of 31, treated with different percentages of Lubrizol 8090 cetane improver ranging from 0.1 to 0.4%. Tests were conducted under steady state conditions at a constant charging pressure of 21 bar. The charge air temperature before fuel injection varied from 778 to 848 K. Accordingly, all the tests were conducted under a constant charge density. The rate of heat release was calculated and analyzed in detail, particularly during the autoignition period. In addition, the physical and chemical delay periods were determined by comparing the results of two tests. The first was conducted with fuel injection into air according to ASTM standards where combustion occurred. In the second test, the fuel was injected into the chamber charged with nitrogen. The physical delay is defined as the period of time from start of injection (SOI) to point of inflection (POI), and the chemical delay is defined as the period of time from POI to start of combustion (SOC). Both the physical and chemical delay periods were determined under different charge temperatures. The cetane improver was found to have an effect only on the chemical ID period. In addition, the effect of the cetane improver on the apparent activation energy of the global combustion reactions was determined. The results showed a linear drop in the apparent activation energy with the increase in the percentage of the cetane improver. Moreover, the low temperature (LT) regimes were investigated and found to be presented in base fuel, as well as cetane improver treated fuels.
C1 [Zheng, Ziliang; Badawy, Tamer; Henein, Naeim] Wayne State Univ, Detroit, MI 48202 USA.
[Sattler, Eric; Johnson, Nicholas] US Army RDECOM TARDEC, Warren, MI 48397 USA.
RP Zheng, ZL (reprint author), Wayne State Univ, 5050 Anthony Wayne Dr,Suite 2100, Detroit, MI 48202 USA.
EM zhengziliang@gmail.com; eng.tam@gmail.com; henein@eng.wayne.edu
FU U.S. Army TARDEC and National Automotive Center (NAC); U.S. Department
of Energy, Next Energy Center and Automotive Research Center (ARC): ARC
is a Center of Excellence in Simulation and Modeling; U.S. Army TARDEC
FX This research was sponsored by the U.S. Army TARDEC and National
Automotive Center (NAC), the U.S. Department of Energy, Next Energy
Center and Automotive Research Center (ARC): ARC is a Center of
Excellence in Simulation and Modeling sponsored by the U.S. Army TARDEC
and lead by the University of Michigan. Our special thanks go to Patsy
Muzzell, P. Schihl and L. Hoogterp-Decker of TARDEC, as well as Kapila
Wadumesthrige and Elena Florea for their technical support. Also, we
would like to thank Dr. Bradley Zigler of the National Renewable Energy
Lab for his technical support, and Wayne State University Center of
Automotive Research members for their help in conducting this research.
NR 41
TC 4
Z9 4
U1 1
U2 4
PU ASME
PI NEW YORK
PA TWO PARK AVE, NEW YORK, NY 10016-5990 USA
SN 0742-4795
EI 1528-8919
J9 J ENG GAS TURB POWER
JI J. Eng. Gas. Turbines Power-Trans. ASME
PD AUG
PY 2014
VL 136
IS 8
AR 081505
DI 10.1115/1.4026812
PG 11
WC Engineering, Mechanical
SC Engineering
GA AJ8JU
UT WOS:000337950300006
ER
PT J
AU Chen, IR
Guo, J
Sao, FY
Cho, JH
AF Chen, Ing-Ray
Guo, Jia
Sao, Fenye
Cho, Jin-Hee
TI Trust management in mobile ad hoc networks for bias minimization and
application performance maximization
SO AD HOC NETWORKS
LA English
DT Article
DE Trust management; Mobile ad hoc networks; Trust bias minimization;
Model-based analysis; Application-level trust optimization; Reliability
assessment
ID DELAY-TOLERANT NETWORKS; ADMISSION CONTROL ALGORITHMS; FORWARDING
STRATEGIES; LOCATION MANAGEMENT; MULTIMEDIA SERVERS; WIRELESS;
OPTIMIZATION; RELIABILITY; SYSTEM; SOFTWARE
AB Trust management for mobile ad hoc networks (MANETs) has emerged as an active research area as evidenced by the proliferation of trust/reputation protocols to support mobile group based applications in recent years. In this paper we address the performance issue of trust management protocol design for MANETs in two important areas: trust bias minimization and application performance maximization. By means of a novel model-based approach to model the ground truth status of mobile nodes in MANETs as the basis for design validation, we identify and validate the best trust protocol settings under which trust bias is minimized and application performance is maximized. We demonstrate the effectiveness of our approach with an integrated social and quality-of-service (QoS) trust protocol (called SQTrust) with which we identify the best trust aggregation setting under which trust bias is minimized despite the presence of malicious nodes performing slandering attacks. Furthermore, using a mission-oriented mobile group utilizing SQTrust, we identity the best trust formation protocol setting under which the application performance in terms of the system reliability of the mission-oriented mobile group is maximized. (C) 2014 Elsevier B.V. All rights reserved.
C1 [Chen, Ing-Ray; Guo, Jia; Sao, Fenye] Virginia Tech, Dept Comp Sci, Falls Church, VA 22043 USA.
[Cho, Jin-Hee] US Army Res Lab, Computat & Informat Sci Directorate, Adelphi, MD USA.
RP Chen, IR (reprint author), Virginia Tech, Dept Comp Sci, 7054 Haycock Rd, Falls Church, VA 22043 USA.
EM irchen@vt.edu; jiaguo@vt.edu; baofenye@vt.edu; jinhee.cho@us.army.mil
FU Army Research Office [W911NF-12-1-0445]
FX This work was supported in part by the Army Research Office under Grant
W911NF-12-1-0445.
NR 75
TC 9
Z9 9
U1 1
U2 18
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1570-8705
EI 1570-8713
J9 AD HOC NETW
JI Ad Hoc Netw.
PD AUG
PY 2014
VL 19
BP 59
EP 74
DI 10.1016/j.adhoc.2014.02.005
PG 16
WC Computer Science, Information Systems; Telecommunications
SC Computer Science; Telecommunications
GA AJ4QF
UT WOS:000337660200005
ER
PT J
AU Shubitidze, F
Fernandez, JP
Barrowes, BE
Shamatava, I
Bijamov, A
O'Neill, K
Karkashadze, D
AF Shubitidze, Fridon
Fernandez, Juan Pablo
Barrowes, Benjamin E.
Shamatava, Irma
Bijamov, Alex
O'Neill, Kevin
Karkashadze, David
TI The Orthonormalized Volume Magnetic Source Model for Discrimination of
Unexploded Ordnance
SO IEEE TRANSACTIONS ON GEOSCIENCE AND REMOTE SENSING
LA English
DT Article
DE Electromagnetic induction (EMI); inverse problems; Time-Domain
Electromagnetic Multisensor Towed Array Detection System (TEMTADS)
sensor; unexploded ordnance (UXO)
ID ELECTROMAGNETIC INDUCTION SENSORS; UXO DISCRIMINATION; DIFFERENTIAL
EVOLUTION; METALLIC OBJECT; EMI RESPONSE; CLASSIFICATION;
IDENTIFICATION; POLARIZABILITIES; DIAGONALIZATION; ALGORITHM
AB We introduce a fast and accurate numerical technique for the solution of electromagnetic induction sensing problems called the orthonormalized volume magnetic source model. The model assumes that the secondary magnetic field measured by a sensor originates from a set of magnetic dipole sources distributed over a volume that coincides with the interrogated area. The Green functions associated with the responding sources are turned into an orthonormal basis using a generalization of the Gram-Schmidt method, enabling one to determine the sources' strengths directly from measured data without having to invert large and potentially ill-conditioned matrices. The method treats multitarget cases naturally and robustly. Several examples are presented to illustrate the applicability of the method in the discrimination of unexploded ordnance (UXO). In particular, we analyze data taken by the Time-Domain Electromagnetic Multisensor Towed Array Detection System sensor array at a test stand and during a blind test administered at a UXO live site. The method is highly successful in distinguishing UXO from among other UXO and from accompanying clutter.
C1 [Shubitidze, Fridon; Fernandez, Juan Pablo; Shamatava, Irma; Bijamov, Alex; O'Neill, Kevin] Dartmouth Coll, Thayer Sch Engn, Hanover, NH 03755 USA.
[Barrowes, Benjamin E.] US Army Corps Engn, Engn Res & Dev Ctr, Cold Regions Res & Engn Lab, Hanover, NH 03755 USA.
[Karkashadze, David] Tbilisi State Univ, Dept Phys, Lab Appl Electrodynam, GE-0179 Tbilisi, Rep of Georgia.
[Karkashadze, David] EMCoS, Electromagnet Consulting & Software Grp, GE-0160 Tbilisi, Rep of Georgia.
RP Shubitidze, F (reprint author), Dartmouth Coll, Thayer Sch Engn, Hanover, NH 03755 USA.
EM fridon.shubitidze@dartmouth.edu
FU Strategic Environmental Research and Development Program [MR-1572,
MR-1664]; Environmental Security Technology Certification Program
[MR-201101]; Army Research Office (ARO) [55000EV]
FX This work was supported in part by the Strategic Environmental Research
and Development Program through Projects MR-1572 and MR-1664, in part by
the Environmental Security Technology Certification Program through
Project MR-201101, and in part by the Army Research Office (ARO) through
Grant 55000EV.
NR 61
TC 5
Z9 6
U1 0
U2 21
PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
PI PISCATAWAY
PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA
SN 0196-2892
EI 1558-0644
J9 IEEE T GEOSCI REMOTE
JI IEEE Trans. Geosci. Remote Sensing
PD AUG
PY 2014
VL 52
IS 8
BP 4658
EP 4670
DI 10.1109/TGRS.2013.2283346
PG 13
WC Geochemistry & Geophysics; Engineering, Electrical & Electronic; Remote
Sensing; Imaging Science & Photographic Technology
SC Geochemistry & Geophysics; Engineering; Remote Sensing; Imaging Science
& Photographic Technology
GA AC5ZC
UT WOS:000332598500015
ER
PT J
AU Wang, ZW
Nasrabadi, NM
Huang, TS
AF Wang, Zhaowen
Nasrabadi, Nasser M.
Huang, Thomas S.
TI Spatial-Spectral Classification of Hyperspectral Images Using
Discriminative Dictionary Designed by Learning Vector Quantization
SO IEEE TRANSACTIONS ON GEOSCIENCE AND REMOTE SENSING
LA English
DT Article
DE Classification; dictionary learning; hyperspectral imagery (HSI);
learning vector quantization (LVQ); sparse representation; spatial
dependence
ID SPARSE REPRESENTATION; K-SVD; ALGORITHM; RECOVERY; PROFILES
AB In this paper, a novel discriminative dictionary learning method is proposed for sparse-representation-based classification (SRC) to label highly dimensional hyperspectral imagery (HSI). In SRC, a dictionary is conventionally constructed using all of the training pixels, which is not only inefficient due to the large size of typical HSI images but also ineffective in capturing class-discriminative information crucial for classification. We address the dictionary design problem with the inspiration from the learning vector quantization technique and propose a hinge loss function that is directly related to the classification task as the objective function for dictionary learning. The resulting online learning procedure systematically "pulls" and "pushes" dictionary atoms so that they become better adapted to distinguish between different classes. In addition, the spatial context for a test pixel within its local neighborhood is modeled using a Bayesian graph model and is incorporated with the sparse representation of a single test pixel in a unified probabilistic framework, which enables further refinement of our dictionary to capture the spatial class dependence that complements the spectral information. Experiments on different HSI images demonstrate that the dictionaries optimized using our method can achieve higher classification accuracy with substantially reduced dictionary size than using the whole training set. The proposed method also outperforms existing dictionary learning methods and attains the state-of-the-art results in both the spectral-only and spatial-spectral settings.
C1 [Wang, Zhaowen; Huang, Thomas S.] Univ Illinois, Beckman Inst Adv Sci & Technol, Dept Elect & Comp Engn, Urbana, IL 61801 USA.
[Nasrabadi, Nasser M.] US Army Res Lab, Adelphi, MD 20783 USA.
RP Wang, ZW (reprint author), Univ Illinois, Beckman Inst Adv Sci & Technol, Dept Elect & Comp Engn, Urbana, IL 61801 USA.
FU U.S. Army Research Laboratory; U.S. Army Research Office
[W911NF-09-1-0383]
FX This work was supported by the U.S. Army Research Laboratory and U.S.
Army Research Office under Grant W911NF-09-1-0383.
NR 42
TC 27
Z9 28
U1 1
U2 55
PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
PI PISCATAWAY
PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA
SN 0196-2892
EI 1558-0644
J9 IEEE T GEOSCI REMOTE
JI IEEE Trans. Geosci. Remote Sensing
PD AUG
PY 2014
VL 52
IS 8
BP 4808
EP 4822
DI 10.1109/TGRS.2013.2285049
PG 15
WC Geochemistry & Geophysics; Engineering, Electrical & Electronic; Remote
Sensing; Imaging Science & Photographic Technology
SC Geochemistry & Geophysics; Engineering; Remote Sensing; Imaging Science
& Photographic Technology
GA AC5ZC
UT WOS:000332598500027
ER
PT J
AU Bijamov, A
Fernandez, JP
Barrowes, BE
Shamatava, I
O'Neill, K
Shubitidze, F
AF Bijamov, Alex
Fernandez, Juan Pablo
Barrowes, Benjamin E.
Shamatava, Irma
O'Neill, Kevin
Shubitidze, Fridon
TI Camp Butner Live-Site UXO Classification Using Hierarchical Clustering
and Gaussian Mixture Modeling
SO IEEE TRANSACTIONS ON GEOSCIENCE AND REMOTE SENSING
LA English
DT Article
DE Agglomerative hierarchical clustering; Camp Butner; classification;
electromagnetic induction (EMI); ESTCP; inverse problems; ONVMS;
semisupervised learning; unexploded ordnance (UXO)
ID UNEXPLODED ORDNANCE DETECTION; MAGNETIC CHARGE MODEL; DIFFERENTIAL
EVOLUTION; METALLIC OBJECT; DISCRIMINATION; ALGORITHM; SELECTION;
TARGETS
AB We demonstrate in detail a semisupervised scheme to classify unexploded ordnance (UXO) by using as an example the data collected with a time-domain electromagnetic towed array detection system during a live-site blind test conducted at the former Camp Butner in North Carolina, USA. The model that we use to characterize targets and generate discrimination features relies on a solution of the inverse UXO problem using the orthonormalized volume magnetic source model. Unlike other classification techniques, which often rely on library matching or expert knowledge, our combined clustering/Gaussian-mixture-model approach first uses the inherent properties of the data in feature space to build a custom training list that is then used to score all unknown targets by assigning them a likelihood of being UXO. The ground truth for the most likely candidates is then requested and used to correct the model parameters and reassign the scores. The process is repeated several times until the desired statistical margin is reached, at which point a final dig is produced. Our method could decrease intervention by human experts and, as the results of the blind test show, identify all targets of interest correctly while minimizing false-alarm counts.
C1 [Bijamov, Alex; Fernandez, Juan Pablo; Barrowes, Benjamin E.; Shamatava, Irma; O'Neill, Kevin; Shubitidze, Fridon] Dartmouth Coll, Thayer Sch Engn, Hanover, NH 03755 USA.
[Barrowes, Benjamin E.] US Army, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA.
[Shamatava, Irma] Sky Res Inc, Hanover, NH 03755 USA.
RP Bijamov, A (reprint author), Dartmouth Coll, Thayer Sch Engn, Hanover, NH 03755 USA.
EM fridon.shubitidze@dartmouth.edu
FU Strategic Environmental Research and Development Program [MR-1572]
FX This work was supported in part by the Strategic Environmental Research
and Development Program under Project MR-1572
NR 60
TC 3
Z9 4
U1 0
U2 29
PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
PI PISCATAWAY
PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA
SN 0196-2892
EI 1558-0644
J9 IEEE T GEOSCI REMOTE
JI IEEE Trans. Geosci. Remote Sensing
PD AUG
PY 2014
VL 52
IS 8
BP 5218
EP 5229
DI 10.1109/TGRS.2013.2287510
PG 12
WC Geochemistry & Geophysics; Engineering, Electrical & Electronic; Remote
Sensing; Imaging Science & Photographic Technology
SC Geochemistry & Geophysics; Engineering; Remote Sensing; Imaging Science
& Photographic Technology
GA AC5ZC
UT WOS:000332598500059
ER
PT J
AU Newburgh, GA
Dubinskii, M
AF Newburgh, G. A.
Dubinskii, M.
TI Compact, high gain, hetero-composite Nd:YVO4/SiC thin disk amplifier
with advanced thermal management
SO ELECTRONICS LETTERS
LA English
DT Article
ID EMISSION CROSS-SECTION; LASER; ND/YVO4; YVO4
AB A thermally advanced, Nd:YVO4 amplifier at 1064 nm based on an 800 mu m-thick Nd:YVO4 gain layer bonded to a silicon carbide (SiC) prism is demonstrated. The amplifier was tested in the 'master oscillator-power amplifier' configuration, where both the seed source and the amplifier were operated in a quasi-continuous-wave regime. The hetero-composite Nd:YVO4/SiC gain element pumped by an 808 nm laser diode bar stack amplified the seed power in a range of 1-55 W with a gain of 4-2.6, respectively. The temperature profile of the gain element measured by a thermal camera indicated the maximum observed temperature excursion at pump saturation intensity to be only 27 degrees C.
C1 [Newburgh, G. A.; Dubinskii, M.] US Army Res Lab, Adelphi, MD 20783 USA.
RP Newburgh, GA (reprint author), US Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA.
EM george.a.newburgh.civ@mail.mil
NR 8
TC 0
Z9 0
U1 2
U2 6
PU INST ENGINEERING TECHNOLOGY-IET
PI HERTFORD
PA MICHAEL FARADAY HOUSE SIX HILLS WAY STEVENAGE, HERTFORD SG1 2AY, ENGLAND
SN 0013-5194
EI 1350-911X
J9 ELECTRON LETT
JI Electron. Lett.
PD JUL 31
PY 2014
VL 50
IS 16
BP 1152
EP +
DI 10.1049/el.2014.1900
PG 2
WC Engineering, Electrical & Electronic
SC Engineering
GA AO0TB
UT WOS:000341023800027
ER
PT J
AU Saunders, DL
Vanachayangkul, P
Lon, C
AF Saunders, David L.
Vanachayangkul, Pattaraporn
Lon, Chanthap
CA US Army Mil Malaria Res Program
Ctr Parasitology Entomology
Royal Cambodian Armed Forces
TI Dihydroartemisinin-Piperaquine Failure in Cambodia
SO NEW ENGLAND JOURNAL OF MEDICINE
LA English
DT Letter
ID FALCIPARUM-MALARIA; PLASMODIUM-FALCIPARUM; EFFICACY
C1 [Saunders, David L.; Vanachayangkul, Pattaraporn] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand.
[Lon, Chanthap] Armed Forces Res Inst Med Sci, Phnom Penh, Cambodia.
RP Saunders, DL (reprint author), Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand.
EM david.saunders@afrims.org
NR 5
TC 57
Z9 57
U1 0
U2 2
PU MASSACHUSETTS MEDICAL SOC
PI WALTHAM
PA WALTHAM WOODS CENTER, 860 WINTER ST,, WALTHAM, MA 02451-1413 USA
SN 0028-4793
EI 1533-4406
J9 NEW ENGL J MED
JI N. Engl. J. Med.
PD JUL 31
PY 2014
VL 371
IS 5
BP 484
EP 485
DI 10.1056/NEJMc1403007
PG 2
WC Medicine, General & Internal
SC General & Internal Medicine
GA AM0SK
UT WOS:000339556900027
PM 25075853
ER
PT J
AU Piyawit, W
Xu, WZ
Mathaudhu, SN
Freudenberger, J
Rigsbee, JM
Zhu, YT
AF Piyawit, W.
Xu, W. Z.
Mathaudhu, S. N.
Freudenberger, J.
Rigsbee, J. M.
Zhu, Y. T.
TI Nucleation and growth mechanism of Ag precipitates in a CuAgZr alloy
SO MATERIALS SCIENCE AND ENGINEERING A-STRUCTURAL MATERIALS PROPERTIES
MICROSTRUCTURE AND PROCESSING
LA English
DT Article
DE Precipitation; Ledge; Interfaces; Copper alloys; Precipitate alignment
ID ELECTRICAL-CONDUCTIVITY; STACKING FAULTS; HIGH-STRENGTH; CONTACT WIRE;
BEHAVIOR; MICROSTRUCTURE; MICROCOMPOSITES; KINETICS; STEELS; STRIP
AB CuAgZr alloy is a variant of the CuAg alloy that is developed for high strength and high conductivity applications. Its strengthening is accomplished mainly by the precipitation of Ag precipitates, which tend to align on {111} planes in the Cu matrix. This alignment has been reported to be caused by stacking faults on {111} planes. Contrary to these reports, this research presents evidence for Ag precipitates formation on {111} planes due to the minimization of elastic energy. The Ag precipitates were formed by clustering of Ag atoms while maintaining the fcc crystal structure of the matrix. They have faceted {111} interfaces with the matrix. The thickening of precipitates appears to be by the ledge growth mechanism, which is resulted in by misfit dislocation networks on the interface. (C) 2014 Elsevier B.V. All rights reserved.
C1 [Piyawit, W.; Xu, W. Z.; Mathaudhu, S. N.; Rigsbee, J. M.; Zhu, Y. T.] N Carolina State Univ, Dept Mat Sci & Engn, Raleigh, NC 27695 USA.
[Mathaudhu, S. N.] US Army Res Off, Div Mat Sci, Res Triangle Pk, NC 27709 USA.
[Freudenberger, J.] IFW Dresden, Inst Metall Mat, D-01171 Dresden, Germany.
[Freudenberger, J.] Tech Univ Bergakad Freiberg, Inst Mat Sci, D-09959 Freiberg, Germany.
RP Zhu, YT (reprint author), N Carolina State Univ, Dept Mat Sci & Engn, Raleigh, NC 27695 USA.
EM ytzhu@ncsu.edu
RI Zhu, Yuntian/B-3021-2008; Mathaudhu, Suveen/B-4192-2009;
OI Zhu, Yuntian/0000-0002-5961-7422; Freudenberger,
Jens/0000-0002-3432-886X
FU U.S. Army Research Office [W011 NF-12-1-0009]; Royal Thai Government
scholarship
FX The authors would like to thank Dr. V.S. Sarma for his contributions.
This work is supported by the U.S. Army Research Office under Grant no.
W011 NF-12-1-0009. One of the authors (Piyawit) acknowledges the Royal
Thai Government scholarship for the financial support.
NR 29
TC 2
Z9 3
U1 3
U2 24
PU ELSEVIER SCIENCE SA
PI LAUSANNE
PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND
SN 0921-5093
EI 1873-4936
J9 MAT SCI ENG A-STRUCT
JI Mater. Sci. Eng. A-Struct. Mater. Prop. Microstruct. Process.
PD JUL 29
PY 2014
VL 610
BP 85
EP 90
DI 10.1016/j.msea.2014.05.023
PG 6
WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary;
Metallurgy & Metallurgical Engineering
SC Science & Technology - Other Topics; Materials Science; Metallurgy &
Metallurgical Engineering
GA AL9JQ
UT WOS:000339457800013
ER
PT J
AU Rao, SS
Lee, YF
Prater, JT
Smirnov, AI
Narayan, J
AF Rao, S. S.
Lee, Y. F.
Prater, J. T.
Smirnov, A. I.
Narayan, J.
TI Laser annealing induced ferromagnetism in SrTiO3 single crystal
SO APPLIED PHYSICS LETTERS
LA English
DT Article
ID INDUCED MAGNETISM; INTERFACE
AB The appearance of ferromagnetic order up to 400K upon KrF (248 nm) laser irradiation is reported in un-doped SrTiO3 (STO) single crystal. The high resolution x-ray photo emission spectroscopy (XPS) measurements reveal a strong shift of Sr-, Ti-, and O-related peaks. X-ray diffraction of laser annealed STO does not reveal a signature of either secondary magnetic or amorphous phases. 300K X-band (similar to 9.543 GHz) angle-dependent electron paramagnetic resonance (EPR) measurements showed no evidence of additional magnetic peaks upon laser irradiation. XPS and EPR data did not provide a strong evidence of Ti3+ formation upon laser annealing. No differences in the visible 300K Raman spectra of pristine and laser annealed STO are noticed. Interestingly, the magnetic moment is decreased by almost 10-fold upon oxygen annealing of laser annealed STO, inferring that oxygen vacancies play an important role in establishing the observed ferromagnetism. (c) 2014 AIP Publishing LLC.
C1 [Rao, S. S.; Prater, J. T.] Army Res Off, Div Mat Sci, Res Triangle Pk, NC 27709 USA.
[Rao, S. S.; Lee, Y. F.; Prater, J. T.; Narayan, J.] N Carolina State Univ, Dept Mat Sci & Engn, Raleigh, NC 27695 USA.
[Smirnov, A. I.] N Carolina State Univ, Dept Chem, Raleigh, NC 27695 USA.
RP Rao, SS (reprint author), Army Res Off, Div Mat Sci, Res Triangle Pk, NC 27709 USA.
EM ssingam@ncsu.edu
RI Smirnov, Alex/Q-9818-2016
OI Smirnov, Alex/0000-0002-0037-2555
FU National Academy of Science (NAS), USA; State of North Carolina;
National Science Foundation; Army Research Office [W911NF-04-D-0003]
FX S.S.R. acknowledges National Academy of Science (NAS), USA for awarding
the NRC postdoctoral research associate fellowship. Also, the authors
acknowledge the use of the Analytical Instrumentation Facility (AIF) at
North Carolina State University, which is supported by the State of
North Carolina and the National Science Foundation. The authors are
pleased to acknowledge the support of the Army Research Office under
Grant W911NF-04-D-0003.
NR 20
TC 7
Z9 7
U1 6
U2 84
PU AMER INST PHYSICS
PI MELVILLE
PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1,
MELVILLE, NY 11747-4501 USA
SN 0003-6951
EI 1077-3118
J9 APPL PHYS LETT
JI Appl. Phys. Lett.
PD JUL 28
PY 2014
VL 105
IS 4
AR 042403
DI 10.1063/1.4891184
PG 4
WC Physics, Applied
SC Physics
GA AO2LB
UT WOS:000341152600049
ER
PT J
AU Kamau, E
Alemayehu, S
Feghali, KC
Komisar, J
Regules, J
Cowden, J
Ockenhouse, CF
AF Kamau, Edwin
Alemayehu, Saba
Feghali, Karla C.
Komisar, Jack
Regules, Jason
Cowden, Jessica
Ockenhouse, Christian F.
TI Measurement of parasitological data by quantitative real-time PCR from
controlled human malaria infection trials at the Walter Reed Army
Institute of Research
SO MALARIA JOURNAL
LA English
DT Article
ID POLYMERASE-CHAIN-REACTION; TO-BLOOD INOCULA; PLASMODIUM-FALCIPARUM;
GROWTH-RATES; IN-VIVO; PARASITEMIA; VOLUNTEERS; CHALLENGE; VACCINES
AB Background: The use of quantitative real-time PCR (qPCR) has allowed for precise quantification of parasites in the prepatent period and greatly improved the reproducibility and statistical power of controlled human malaria infection (CHMI) trials. Parasitological data presented here are from non-immunized, control-challenged subjects who participated in two CHMI trials conducted at the Walter Reed Army Institute of Research (WRAIR).
Methods: Standardized sporozoite challenge was achieved through the bite of five Anopheles stephensi mosquitoes infected with the 3D7clone of the NF54 strain of Plasmodium falciparum. Blood smears were scored positive when two unambiguous parasites were found. Analysis of parasitological PCR data was performed on log-transformed data using an independent sample t-test when comparing the two studies. The multiplication rate of blood-stage parasites was estimated using the linear model.
Results: On average, parasites were detected 4.91 days (95% CI = 4.190 to 5.627) before smears. The earliest parasites were detected within 120 hours (5.01 days) after challenge. Parasite densities showed consistent cyclic patterns of blood-stage parasite growth in all volunteers. The parasite multiplication rates for both studies was 8.18 (95% CI = 6.162 to 10.20). Data showed that at low parasite densities, a combination of sequestration and stochastic effects of low copy number DNA may impact qPCR detection and the parasite detection limit.
Conclusion: Smear positive is an endpoint which antimalarial rescue is imperative whereas early detection of parasitological data by qPCR can allow for better anticipation of the endpoint. This would allow for early treatment to reduce clinical illness and risk for study participants. To use qPCR as the primary endpoint in CHMI trials, an algorithm of two positives by qPCR where one of the positives must have parasite density of at least 2 parasites/mu L is proposed.
C1 [Kamau, Edwin; Alemayehu, Saba; Feghali, Karla C.; Komisar, Jack; Regules, Jason; Cowden, Jessica; Ockenhouse, Christian F.] Walter Reed Army Inst Res, Malaria Vaccine Branch, Mil Malaria Res Program, Silver Spring, MD 20910 USA.
RP Kamau, E (reprint author), Walter Reed Army Inst Res, Malaria Vaccine Branch, Mil Malaria Res Program, 503 Robert Grant Ave, Silver Spring, MD 20910 USA.
EM edwin.kamau@us.army.mil
NR 20
TC 3
Z9 3
U1 2
U2 7
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1475-2875
J9 MALARIA J
JI Malar. J.
PD JUL 28
PY 2014
VL 13
AR 288
DI 10.1186/1475-2875-13-288
PG 8
WC Infectious Diseases; Parasitology; Tropical Medicine
SC Infectious Diseases; Parasitology; Tropical Medicine
GA AN5MH
UT WOS:000340634900001
PM 25066459
ER
PT J
AU Li, QG
Remich, S
Miller, SR
Ogutu, B
Otieno, W
Melendez, V
Teja-Isavadharm, P
Weina, PJ
Hickman, MR
Smith, B
Polhemus, M
AF Li, Qigui
Remich, Shon
Miller, Scott R.
Ogutu, Bernhards
Otieno, Walter
Melendez, Victor
Teja-Isavadharm, Paktiya
Weina, Peter J.
Hickman, Mark R.
Smith, Bryan
Polhemus, Mark
TI Pharmacokinetic evaluation of intravenous artesunate in adults with
uncomplicated falciparum malaria in Kenya: a phase II study
SO MALARIA JOURNAL
LA English
DT Article
DE Artesunate; Dihydroartemisinin; Pharmacokinetics; Intravenous;
Uncomplicated falciparum malaria; Clinical trial
ID PLASMODIUM-FALCIPARUM; HEALTHY-VOLUNTEERS; CLINICAL EFFICACY; 8 MG/KG;
BIOAVAILABILITY; DIHYDROARTEMISININ; CHILDREN; QUININE; NEUROTOXICITY;
ARTEETHER
AB Background: Alternatives to treatment for malaria treatment of travellers are needed in the USA and in Europe for travellers who return with severe malaria infections. The objective of this study is to show the pharmacokinetic (PK) profile of intravenous artesunate (AS), which was manufactured under good manufacturing practice (GMP) conditions, in adults with uncomplicated falciparum malaria in Kenya.
Methods: The PK parameters of intravenous AS manufactured under current cGMP were evaluated after a single dose of drug at 2.4 mg/kg infused over 2 min in 28 adults with uncomplicated Plasmodium falciparum malaria. Plasma concentrations of AS and dihydroartemisinin (DHA) were measured using a validated liquid chromatography-mass spectrometry (LC-MS/MS) methodology. Pharmacokinetic data were analysed with a compartmental analysis for AS and DHA.
Results: The results suggest there were no drug-related adverse events in any of the patients. After intravenous infusion, the concentration of the parent drug rapidly declined, and the AS was converted to DHA. AS and DHA showed mean elimination half-lives of 0.17 hours and 1.30 hours, respectively. The high mean peak concentration (C-max) of AS was shown to be 28,558 ng/mL while the C-max of DHA was determined to be 2,932 ng/mL. Significant variability was noted in the PK profiles of the 28 patients tested. For example, C-max values of AS were calculated to range from 3,362 to 55,873 ng/mL, and the C-max value of DHA was noted to vary from 1,493 to 5,569 ng/mL. The mean area under the curve (AUC) of AS was shown to be approximately half that of DHA (1,878 ng.h/mL vs 3,543 ng.h/mL). The DHA/AS ratio observed was 1.94 during the one-day single treatment, and the AUC and half-life measured for DHA were significantly larger and longer than for AS.
Conclusions: Intravenous AS can provide much higher peak concentrations of AS when compared to concentrations achieved with oral therapy; this may be crucial for the rapid elimination of parasites in patients with severe malaria. Given the much longer half-life of DHA compared to the short half-life of AS, DHA also plays a significant role in treatment of severe malaria.
C1 [Li, Qigui; Remich, Shon; Miller, Scott R.; Melendez, Victor; Weina, Peter J.; Hickman, Mark R.] Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD 20910 USA.
[Ogutu, Bernhards; Otieno, Walter] US Army Med Res Unit, Kisumu Res Stn, Kisumu, Kenya.
[Teja-Isavadharm, Paktiya; Smith, Bryan] Armed Forces Res Inst Med Sci, Dept Immunol & Med, Bangkok 10400, Thailand.
RP Li, QG (reprint author), Walter Reed Army Inst Res, Div Expt Therapeut, 503 Robert Grant Ave, Silver Spring, MD 20910 USA.
EM qigui.li.civ@mail.mil
FU US Army Research and Materiel Command
FX This study was supported by the US Army Research and Materiel Command.
Material has been reviewed by the Walter Reed Army Institute of
Research. There is no objection to its presentation and/or publication.
The opinions or assertions contained herein are the private views of the
authors and are not to be construed as official, or as reflecting the
views of the Department of the Army or the Department of Defense.
NR 32
TC 1
Z9 1
U1 0
U2 4
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1475-2875
J9 MALARIA J
JI Malar. J.
PD JUL 22
PY 2014
VL 13
AR 281
DI 10.1186/1475-2875-13-281
PG 9
WC Infectious Diseases; Parasitology; Tropical Medicine
SC Infectious Diseases; Parasitology; Tropical Medicine
GA AN5LR
UT WOS:000340633200001
PM 25047305
ER
PT J
AU Khmaladze, E
Birdsell, DN
Naumann, AA
Hochhalter, CB
Seymour, ML
Nottingham, R
Beckstrom-Sternberg, SM
Beckstrom-Sternberg, J
Nikolich, MP
Chanturia, G
Zhgenti, E
Zakalashvili, M
Malania, L
Babuadze, G
Tsertsvadze, N
Abazashvili, N
Kekelidze, M
Tsanava, S
Imnadze, P
Ganz, HH
Getz, WM
Pearson, O
Gajer, P
Eppinger, M
Ravel, J
Wagner, DM
Okinaka, RT
Schupp, JM
Keim, P
Pearson, T
AF Khmaladze, Ekaterine
Birdsell, Dawn N.
Naumann, Amber A.
Hochhalter, Christian B.
Seymour, Meagan L.
Nottingham, Roxanne
Beckstrom-Sternberg, Stephen M.
Beckstrom-Sternberg, James
Nikolich, Mikeljon P.
Chanturia, Gvantsa
Zhgenti, Ekaterine
Zakalashvili, Mariam
Malania, Lile
Babuadze, Giorgi
Tsertsvadze, Nikoloz
Abazashvili, Natalia
Kekelidze, Merab
Tsanava, Shota
Imnadze, Paata
Ganz, Holly H.
Getz, Wayne M.
Pearson, Ofori
Gajer, Pawel
Eppinger, Mark
Ravel, Jacques
Wagner, David M.
Okinaka, Richard T.
Schupp, James M.
Keim, Paul
Pearson, Talima
TI Phylogeography of Bacillus anthracis in the Country of Georgia Shows
Evidence of Population Structuring and Is Dissimilar to Other Regional
Genotypes
SO PLOS ONE
LA English
DT Article
ID STRAINS; DIVERSITY
AB Sequence analyses and subtyping of Bacillus anthracis strains from Georgia reveal a single distinct lineage (Aust94) that is ecologically established. Phylogeographic analysis and comparisons to a global collection reveals a clade that is mostly restricted to Georgia. Within this clade, many groups are found around the country, however at least one subclade is only found in the eastern part. This pattern suggests that dispersal into and out of Georgia has been rare and despite historical dispersion within the country, for at least for one lineage, current spread is limited.
C1 [Khmaladze, Ekaterine; Chanturia, Gvantsa; Zhgenti, Ekaterine; Zakalashvili, Mariam; Malania, Lile; Babuadze, Giorgi; Tsertsvadze, Nikoloz; Abazashvili, Natalia; Kekelidze, Merab; Tsanava, Shota; Imnadze, Paata] Natl Ctr Dis Control & Publ Hlth, Tbilisi, Rep of Georgia.
[Birdsell, Dawn N.; Naumann, Amber A.; Hochhalter, Christian B.; Seymour, Meagan L.; Nottingham, Roxanne; Beckstrom-Sternberg, Stephen M.; Beckstrom-Sternberg, James; Wagner, David M.; Okinaka, Richard T.; Schupp, James M.; Keim, Paul; Pearson, Talima] Univ Arizona, Ctr Microbial Genet & Genom, Flagstaff, AZ 86011 USA.
[Nikolich, Mikeljon P.] Walter Reed Army Inst Res, Silver Spring, MD USA.
[Ganz, Holly H.; Getz, Wayne M.] Univ Calif Berkeley, Dept Environm Sci Policy & Management, Berkeley, CA 94720 USA.
[Pearson, Ofori] US Geol Survey, Denver Fed Ctr, Denver, CO 80225 USA.
[Gajer, Pawel; Eppinger, Mark; Ravel, Jacques] Inst Genome Sci, Baltimore, MD USA.
[Eppinger, Mark] Univ Texas San Antonio, San Antonio, TX USA.
[Khmaladze, Ekaterine; Tsanava, Shota; Imnadze, Paata] Ivane Javakhishvili Tbilisi State Univ, Tbilisi, Rep of Georgia.
RP Pearson, T (reprint author), Univ Arizona, Ctr Microbial Genet & Genom, Flagstaff, AZ 86011 USA.
EM Talima.Pearson@nau.edu
OI Getz, Wayne/0000-0001-8784-9354; Ravel, Jacques/0000-0002-0851-2233
FU U.S. Department of Homeland Security S&T CB Division Bioforensics RD
Program [HSHQDC-10-C-00139]; Department of Defense's Defense Threat
Reduction Agency [CBCALL12-DIAGB1-2-0194]; National Institutes of Health
[GM083863]
FX This work was funded by the U.S. Department of Homeland Security S&T CB
Division Bioforensics R&D Program (HSHQDC-10-C-00139) and by the
Department of Defense's Defense Threat Reduction Agency
(CBCALL12-DIAGB1-2-0194). Support for collecting the samples in Namibia
was provided by National Institutes of Health GM083863 grant to Wayne M.
Getz. The use of products/names does not constitute endorsement by the
United States DHS. The findings and opinions expressed herein belong to
the authors and do not necessarily reflect the official views of the
Walter Reed Army Institute of Research, the U.S. Army or the Department
of Defense. The funders had no role in study design, data collection and
analysis, decision to publish, or preparation of the manuscript.
NR 15
TC 8
Z9 8
U1 0
U2 7
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD JUL 21
PY 2014
VL 9
IS 7
AR e102651
DI 10.1371/journal.pone.0102651
PG 4
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA AM0SW
UT WOS:000339558100057
PM 25047912
ER
PT J
AU Tian, LM
Tadepalli, S
Farrell, ME
Liu, KK
Gandra, N
Pellegrino, PM
Singamaneni, S
AF Tian, Limei
Tadepalli, Sirimuvva
Farrell, Mikella E.
Liu, Keng-Ku
Gandra, Naveen
Pellegrino, Paul M.
Singamaneni, Srikanth
TI Multiplexed charge-selective surface enhanced Raman scattering based on
plasmonic calligraphy
SO JOURNAL OF MATERIALS CHEMISTRY C
LA English
DT Article
ID SINGLE-MOLECULE; GOLD NANORODS; EXCITATION SPECTROSCOPY;
CHEMICAL-DETECTION; SERS; PAPER; NANOPARTICLES; SILVER; NANOSTRUCTURES;
DIAGNOSTICS
AB Multiplexed surface enhanced Raman scattering (SERS) substrates, which enable chemically selective detection of two or more target analytes from a complex chemical mixture, are highly attractive for chemical detection in real-world settings. We introduce a new approach called plasmonic calligraphy that involves the formation of chemically selective test domains on paper substrates using functionalized plasmonic nanostructures as ink in a regular ballpoint pen. We demonstrate selective detection of positively and negatively charged analytes (rhodamine 6G and methyl orange) from complex chemical mixtures using polyelectrolyte-coated gold nanorods as SERS medium. The approach demonstrated here obviates the need for complex patterning techniques such as photolithography to create isolated test domains on paper substrates for multiplexed chemical detection. Plasmonic calligraphy can be easily extended to other shape-controlled nanostructures with different surface functionalities and potentially automated by implementation with a robotic arm.
C1 [Tian, Limei; Tadepalli, Sirimuvva; Liu, Keng-Ku; Gandra, Naveen; Singamaneni, Srikanth] Washington Univ, Inst Mat Sci & Engn, Dept Mech Engn & Mat Sci, St Louis, MO 63130 USA.
[Farrell, Mikella E.; Pellegrino, Paul M.] US Army, Res Lab, Sensors & Elect Devices Directorate, Adelphi, MD 20783 USA.
RP Singamaneni, S (reprint author), Washington Univ, Inst Mat Sci & Engn, Dept Mech Engn & Mat Sci, St Louis, MO 63130 USA.
EM singamaneni@wustl.edu
OI Tadepalli, Sirimuvva/0000-0001-9658-9988
FU Army Research Office (ARO) [W911NF-11-2-0091]; Army Research Lab (ARL)
[W911NF-11-2-0091]; National Science Foundation CAREER award
FX This work was supported by Army Research Office (ARO) and Army Research
Lab (ARL) under Contract no. W911NF-11-2-0091 and National Science
Foundation CAREER award. We would like thank Nano Research Facility
(NRF), a member of the National Nanotechnology Infrastructure Network
(NNIN), for providing access to electron microscopy facilities.
NR 49
TC 10
Z9 10
U1 0
U2 34
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
ENGLAND
SN 2050-7526
EI 2050-7534
J9 J MATER CHEM C
JI J. Mater. Chem. C
PD JUL 21
PY 2014
VL 2
IS 27
BP 5438
EP 5446
DI 10.1039/c4tc00768a
PG 9
WC Materials Science, Multidisciplinary; Physics, Applied
SC Materials Science; Physics
GA AK7IK
UT WOS:000338601800025
ER
PT J
AU Soller, B
Srikiatkachorn, A
Zou, FM
Rothman, AL
Yoon, IK
Gibbons, RV
Kalayanarooj, S
Thomas, SJ
Green, S
AF Soller, Babs
Srikiatkachorn, Anon
Zou, Fengmei
Rothman, Alan L.
Yoon, In-Kyu
Gibbons, Robert V.
Kalayanarooj, Siripen
Thomas, Stephen J.
Green, Sharone
TI Preliminary evaluation of near infrared spectroscopy as a method to
detect plasma leakage in children with dengue hemorrhagic fever
SO BMC INFECTIOUS DISEASES
LA English
DT Article
ID MUSCLE OXYGEN-SATURATION; NONINVASIVE MEASUREMENT; CENTRAL HYPOVOLEMIA
AB Background: Dengue viral infections are prevalent in the tropical and sub-tropical regions of the world, resulting in substantial morbidity and mortality. Clinical manifestations range from a self-limited fever to a potential life-threatening plasma leakage syndrome (dengue hemorrhagic fever). The objective of this study was to assess the utility of near infrared spectroscopy (NIRS) measurements of muscle oxygen saturation (SmO2) as a possible continuous measure to detect plasma leakage in children with dengue.
Methods: Children ages 6 months to 15 years of age admitted with suspected dengue were enrolled from the dengue ward at Queen Sirikit National Institute for Child Health. Children were monitored daily until discharge. NIRS data were collected continuously using a prototype CareGuide Oximeter 1100 with sensors placed on the deltoid or thigh. Daily ultrasound of the chest and a right lateral decubitus chest x-ray the day after defervescence were performed to detect and quantitate plasma leakage in the pleural cavity.
Results: NIRS data were obtained from 19 children with laboratory-confirmed dengue. Average minimum SmO2 decreased for all subjects prior to defervescence. Average minimum SmO2 subsequently increased in children with no ultrasound evidence of pleural effusion but remained low in children with pleural effusion following defervescence. Average minimum SmO2 was inversely correlated with pleural space fluid volume. ROC analysis revealed a cut-off value for SmO2 which yielded high specificity and sensitivity.
Conclusions: SmO2 measured using NIRS may be a useful guide for real-time and non-invasive identification of plasma leakage in children with dengue. Further investigation of the utility of NIRS measurements for prediction and management of severe dengue syndromes is warranted.
C1 [Soller, Babs; Zou, Fengmei] Reflectance Med Inc, Westborough, MA 01581 USA.
[Soller, Babs] Univ Massachusetts, Sch Med, Dept Anesthesiol, Worcester, MA 01655 USA.
[Srikiatkachorn, Anon; Green, Sharone] Univ Massachusetts, Sch Med, Div Infect Dis & Immunol, Worcester, MA 01655 USA.
[Srikiatkachorn, Anon; Yoon, In-Kyu; Gibbons, Robert V.] Armed Forces Res Inst Med Sci, Dept Virol, Bangkok 10400, Thailand.
[Rothman, Alan L.] Univ Rhode Isl, Inst Immunol & Informat, Providence, RI 02903 USA.
[Kalayanarooj, Siripen] Queen Sirikit Natl Inst Child Hlth, Bangkok 10400, Thailand.
[Thomas, Stephen J.] Walter Reed Army Inst Res, Viral Dis Branch, Silver Spring, MD 20910 USA.
RP Soller, B (reprint author), Reflectance Med Inc, 116 Flanders Rd,Suite 1000, Westborough, MA 01581 USA.
EM babs.soller@reflectancemedical.com
FU Department of Virology, Armed Forces Research Institute of Medical
Sciences; National Institutes of Health [NIH-P01AI34533]; Military
Infectious Disease Research Program; Telemedicine & Advanced Technology
Research Center
FX The authors thank the staff of the Department of Virology, Armed Forces
Research Institute of Medical Sciences for sample collection, diagnostic
testing, and research support; Dr. Suchitra Nimmannitya for reviewing
the clinical diagnoses; doctors and nurses of the Queen Sirikit National
Institute of Child Health for patient care; and the subjects and
families who participated in this study. This work was supported by
National Institutes of Health Grant NIH-P01AI34533 (AS ALR SG SK), the
Military Infectious Disease Research Program (RVG IY SJT SK) and the
Telemedicine & Advanced Technology Research Center (BS FZ).
NR 16
TC 0
Z9 0
U1 1
U2 6
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1471-2334
J9 BMC INFECT DIS
JI BMC Infect. Dis.
PD JUL 17
PY 2014
VL 14
AR 396
DI 10.1186/1471-2334-14-396
PG 6
WC Infectious Diseases
SC Infectious Diseases
GA AM0HI
UT WOS:000339524700001
PM 25033831
ER
PT J
AU Schmaljohn, CS
Spik, KW
Hooper, JW
AF Schmaljohn, Connie S.
Spik, Kristin W.
Hooper, Jay W.
TI DNA vaccines for HFRS: Laboratory and clinical studies
SO VIRUS RESEARCH
LA English
DT Article
DE Hemorrhagic fever with renal syndrome; Hantaviruses; DNA vaccine;
Electroporation; Phase 1 clinical study
ID HANTAAN-VIRUS; PUUMALA VIRUS; ENCEPHALITIS-VIRUS; MONOCLONAL-ANTIBODY;
HEMORRHAGIC-FEVER; NONHUMAN-PRIMATES; RENAL SYNDROME; M-GENOME;
IMMUNOGENICITY; VACCINATION
AB DNA vaccines can be constructed to produce specific immunogens while avoiding the risks associated with propagating infectious viruses. Plasmid DNA vaccines have well established manufacturing procedures and are safe in that they are replication defective, cannot revert to virulence and cannot be transmitted from person-to-person or into the environment. In addition, DNA vaccines can be combined to form multivalent formulations and can be delivered by a variety of methods. Because of these numerous advantages, we have developed DNA vaccines expressing the envelope glycoprotein genes of hantaviruses causing hemorrhagic fever with renal syndrome (HFRS). We have demonstrated that these DNA vaccines elicit neutralizing antibodies in multiple laboratory animal species when delivered to skin or muscle tissues. Moreover, these vaccines delivered as active vaccines or passive vaccines (e.g., transfer of sera from vaccinated rabbits or nonhuman primates), protected hamsters from infection with HFRS-causing hantaviruses. Early clinical studies of HFRS vaccines expressing Hantaan virus or Puumala virus genes have been completed and show promise for further development. Despite these advantages, issues relating to inconsistent immunogenicity and immune interference remain to be addressed. Published by Elsevier B.V.
C1 [Schmaljohn, Connie S.; Spik, Kristin W.; Hooper, Jay W.] US Army, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA.
RP Schmaljohn, CS (reprint author), US Army, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA.
EM connie.schmaljohn@us.army.mil
OI Hooper, Jay/0000-0002-4475-0415
NR 21
TC 7
Z9 7
U1 0
U2 5
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0168-1702
EI 1872-7492
J9 VIRUS RES
JI Virus Res.
PD JUL 17
PY 2014
VL 187
BP 91
EP 96
DI 10.1016/j.virusres.2013.12.020
PG 6
WC Virology
SC Virology
GA AL6CO
UT WOS:000339220000015
PM 24370868
ER
PT J
AU Memisevic, V
Kumar, K
Cheng, L
Zavaljevski, N
DeShazer, D
Wallqvist, A
Reifman, J
AF Memisevic, Vesna
Kumar, Kamal
Cheng, Li
Zavaljevski, Nela
DeShazer, David
Wallqvist, Anders
Reifman, Jaques
TI DBSecSys: a database of Burkholderia mallei secretion systems
SO BMC BIOINFORMATICS
LA English
DT Article
DE Bacterial secretion system; Virulence factors; Pathogenic mechanisms of
action; Host-pathogen interactions; Burkholderia mallei
ID VIRULENCE FACTORS; BIOTECHNOLOGY-INFORMATION; BIOINFORMATICS RESOURCE;
PROTEIN INTERACTIONS; NATIONAL-CENTER; GENE ONTOLOGY; VI SECRETION;
PSEUDOMALLEI; UPDATE; MELIOIDOSIS
AB Background: Bacterial pathogenicity represents a major public health concern worldwide. Secretion systems are a key component of bacterial pathogenicity, as they provide the means for bacterial proteins to penetrate host-cell membranes and insert themselves directly into the host cells' cytosol. Burkholderia mallei is a Gram-negative bacterium that uses multiple secretion systems during its host infection life cycle. To date, the identities of secretion system proteins for B. mallei are not well known, and their pathogenic mechanisms of action and host factors are largely uncharacterized.
Description: We present the Database of Burkholderia mallei Secretion Systems (DBSecSys), a compilation of manually curated and computationally predicted bacterial secretion system proteins and their host factors. Currently, DBSecSys contains comprehensive experimentally and computationally derived information about B. mallei strain ATCC 23344. The database includes 143 B. mallei proteins associated with five secretion systems, their 1,635 human and murine interacting targets, and the corresponding 2,400 host-B. mallei interactions. The database also includes information about 10 pathogenic mechanisms of action for B. mallei secretion system proteins inferred from the available literature. Additionally, DBSecSys provides details about 42 virulence attenuation experiments for 27 B. mallei secretion system proteins. Users interact with DBSecSys through a Web interface that allows for data browsing, querying, visualizing, and downloading.
Conclusions: DBSecSys provides a comprehensive, systematically organized resource of experimental and computational data associated with B. mallei secretion systems. It provides the unique ability to study secretion systems not only through characterization of their corresponding pathogen proteins, but also through characterization of their host-interacting partners.
C1 [Memisevic, Vesna; Kumar, Kamal; Cheng, Li; Zavaljevski, Nela; Wallqvist, Anders; Reifman, Jaques] US Army Med Res & Mat Command, Telemed & Adv Technol Res Ctr, US Dept Def, Biotechnol High Performance Comp Software Applica, Ft Detrick, MD 21702 USA.
[DeShazer, David] US Army Med Res Inst Infect Dis, Bacteriol Div, Ft Detrick, MD 21702 USA.
RP Reifman, J (reprint author), US Army Med Res & Mat Command, Telemed & Adv Technol Res Ctr, US Dept Def, Biotechnol High Performance Comp Software Applica, Ft Detrick, MD 21702 USA.
EM jaques.reifman.civ@mail.mil
OI Kumar, Kamal/0000-0002-9470-6682; wallqvist, anders/0000-0002-9775-7469
FU Defense Threat Reduction Agency [CBS.MEDBIO.02.10.BH.021]; U.S. Army
Medical Research and Materiel Command (Ft. Detrick, MD), U.S. Army's
Network Science Initiative
FX This work was supported by the Defense Threat Reduction Agency (project
CBS.MEDBIO.02.10.BH.021) and by the U.S. Army Medical Research and
Materiel Command (Ft. Detrick, MD) as part of the U.S. Army's Network
Science Initiative.
NR 44
TC 6
Z9 6
U1 0
U2 6
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1471-2105
J9 BMC BIOINFORMATICS
JI BMC Bioinformatics
PD JUL 16
PY 2014
VL 15
AR 244
DI 10.1186/1471-2105-15-244
PG 9
WC Biochemical Research Methods; Biotechnology & Applied Microbiology;
Mathematical & Computational Biology
SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology;
Mathematical & Computational Biology
GA AL8RJ
UT WOS:000339406400001
PM 25030112
ER
PT J
AU Gil, S
Kott, A
Barabasi, AL
AF Gil, Santiago
Kott, Alexander
Barabasi, Albert-Laszlo
TI A genetic epidemiology approach to cyber-security
SO SCIENTIFIC REPORTS
LA English
DT Article
ID ATTACK; ASSOCIATION; CHALLENGES; NETWORKS
AB While much attention has been paid to the vulnerability of computer networks to node and link failure, there is limited systematic understanding of the factors that determine the likelihood that a node (computer) is compromised. We therefore collect threat log data in a university network to study the patterns of threat activity for individual hosts. We relate this information to the properties of each host as observed through network-wide scans, establishing associations between the network services a host is running and the kinds of threats to which it is susceptible. We propose a methodology to associate services to threats inspired by the tools used in genetics to identify statistical associations between mutations and diseases. The proposed approach allows us to determine probabilities of infection directly from observation, offering an automated high-throughput strategy to develop comprehensive metrics for cyber-security.
C1 [Gil, Santiago; Barabasi, Albert-Laszlo] Northeastern Univ, Ctr Complex Network Res, Boston, MA 02130 USA.
[Gil, Santiago] Seed Sci, New York, NY 10013 USA.
[Kott, Alexander] Army Res Lab, Network Sci Div, Adelphi, MD 20783 USA.
[Barabasi, Albert-Laszlo] Dana Farber Canc Inst, Ctr Canc Syst Biol, Boston, MA 02115 USA.
[Barabasi, Albert-Laszlo] Harvard Univ, Brigham & Womens Hosp, Dept Med, Sch Med, Boston, MA 02115 USA.
RP Gil, S (reprint author), Northeastern Univ, Ctr Complex Network Res, Boston, MA 02130 USA.
EM sg.ccnr@gmail.com
FU Army Research Lab (ARL) under the project "Metrics for monitoring
robustness and controllability'' [W911NF-11-2-0086]
FX The authors would like to thank Dr. Hasan Cam, Dr. Engin Kirda and David
Blank-Edelman for valuable discussions and fruitful advice. Special
thanks to Rajiv Shridhar, Ray Lisiecki and Joseph De Nicolo for their
essential support with the data collection. This research was supported
by the Army Research Lab (ARL) through Grant W911NF-11-2-0086, under the
project "Metrics for monitoring robustness and controllability''.
NR 31
TC 4
Z9 4
U1 0
U2 18
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD JUL 16
PY 2014
VL 4
AR 5659
DI 10.1038/srep05659
PG 7
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA AL2YJ
UT WOS:000338991300001
PM 25028059
ER
PT J
AU Redding, B
Pan, YL
Wang, CJ
Cao, H
AF Redding, Brandon
Pan, Yong-Le
Wang, Chuji
Cao, Hui
TI Polarization-resolved near-backscattering of airborne aggregates
composed of different primary particles
SO OPTICS LETTERS
LA English
DT Article
ID LIGHT-SCATTERING; NEGATIVE POLARIZATION; SPECTRA; SIZE
AB We measured the polarization-resolved angular elastic scattering intensity distribution of aggregates composed of primary particles with different shapes and packing densities in the near-backward directions (155 degrees-180 degrees). Specifically, we compare aggregates composed of spherical polystyrene latex spheres, cylinder-like Bacillus subtilis particles, and Arizona road dust, as well as tryptophan particles. We observe clearly differentiable polarization aspect ratios and find that the negative polarization dip is more pronounced in more densely packed aggregates or particles. This work indicates that the polarization aspect ratio in the near-backward direction may be used as a fingerprint to discriminate between aggregates with the same size and overall shape by differences in their constituent particles. (C) 2014 Optical Society of America
C1 [Redding, Brandon; Cao, Hui] Yale Univ, Dept Appl Phys, New Haven, CT 06520 USA.
[Pan, Yong-Le; Wang, Chuji] US Army, Res Lab, Adelphi, MD 20783 USA.
[Wang, Chuji] Mississippi State Univ, Dept Phys, Starkville, MS 39759 USA.
RP Cao, H (reprint author), Yale Univ, Dept Appl Phys, New Haven, CT 06520 USA.
EM hui.cao@yale.edu
FU Army Research Office [W911NF-12-1-0507]
FX We thank Gorden Videen and Richard Chang for useful discussions. This
work was supported by the Army Research Office under Grant No.
W911NF-12-1-0507.
NR 17
TC 1
Z9 1
U1 2
U2 7
PU OPTICAL SOC AMER
PI WASHINGTON
PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA
SN 0146-9592
EI 1539-4794
J9 OPT LETT
JI Opt. Lett.
PD JUL 15
PY 2014
VL 39
IS 14
BP 4076
EP 4079
DI 10.1364/OL.39.004076
PG 4
WC Optics
SC Optics
GA AL2CS
UT WOS:000338934100005
PM 25121655
ER
PT J
AU Hauck, BC
Davis, EJ
Clark, AE
Siems, WF
Harden, CS
McHugh, VM
Hill, HH
AF Hauck, Brian C.
Davis, Eric J.
Clark, Aurora E.
Siems, William F.
Harden, Charles S.
McHugh, Vincent M.
Hill, Herbert H., Jr.
TI Determining the water content of a drift gas using reduced ion mobility
measurements
SO INTERNATIONAL JOURNAL OF MASS SPECTROMETRY
LA English
DT Article
DE Ion mobility spectrometry; Time-of-flight mass spectrometry; Atmospheric
measurements; Water content; DMMP
ID CHEMICAL WARFARE AGENTS; DIMETHYL METHYLPHOSPHONATE;
ELECTROSPRAY-IONIZATION; ILLICIT DRUGS; SPECTROMETRY; PHASE; EXPLOSIVES;
SOLVATION; HYDROGEN; DENSITY
AB Ion mobility spectrometry is widely used in national defense areas, and field-deployed IMS units are subject to various environmental conditions; one of the most important and least controlled being the humidity of the sample and drift gas. Varying drift gas water content can significantly alter the drift time and reduce the mobility constant (K-0 value) of the ion. While the effect of drift gas water content has been previously characterized, no means to quantitatively measure the water content of the drift gas under field conditions have been developed. In this work, using an IMS-TOFMS instrument capable of high precision (+/- 0.005 cm(2) V-1 s(-1) better) measurements of K-0 values, we investigated the protonated monomer and proton-bound dimer ions of dimethyl methylphosphonate as standards that are sensitive and insensitive, respectively, to the formation of water cluster ions. It was found that the ratio of mobilities of these two ions could measure the water content of the drift gas in field-deployed instruments. When water vapor was added in the presence of an ammonia dopant, K-0 was found to decrease as a function of water content to a lesser degree than under conditions without dopant. This study was conducted at atmospheric pressure and at temperatures from 30 degrees C to 150 degrees C. The experimental data were supported by complementary density functional theory calculations that examined the interactions of the DMMP monomer with successive number of waters. The reduced ion mobility cross-sections in N-2 were subsequently predicted using the trajectory method. (C) 2014 Elsevier B.V. All rights reserved.
C1 [Hauck, Brian C.; Clark, Aurora E.; Siems, William F.; Hill, Herbert H., Jr.] Washington State Univ, Dept Chem, Pullman, WA 99164 USA.
[Davis, Eric J.] Fresno Pacif Univ, Fresno, CA 93702 USA.
[Harden, Charles S.] US Army, ECBC Operat, LEIDOS, Gunpowder, MD 21010 USA.
[McHugh, Vincent M.] US Army, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA.
RP Hill, HH (reprint author), Washington State Univ, Dept Chem, 305 Fulmer Hall, Pullman, WA 99164 USA.
EM brian.hauck@wsu.edu; hhhill@wsu.edu
FU LEIDOS; U.S. Army Edgewood Chemical Biological Center; U.S. Army
Research Laboratory's Army Research Office [W911NF-12-1-0575]
FX Funding for this effort was provided by Science Applications
International Corporation, now LEIDOS, as a subcontract under a Task
Order contract with U.S. Army Edgewood Chemical Biological Center and
has been continued with the U.S. Army Research Laboratory's Army
Research Office under grant #W911NF-12-1-0575.
NR 32
TC 2
Z9 2
U1 2
U2 32
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1387-3806
EI 1873-2798
J9 INT J MASS SPECTROM
JI Int. J. Mass Spectrom.
PD JUL 15
PY 2014
VL 368
BP 37
EP 44
DI 10.1016/j.ijms.2014.05.010
PG 8
WC Physics, Atomic, Molecular & Chemical; Spectroscopy
SC Physics; Spectroscopy
GA AK7KC
UT WOS:000338606200006
ER
PT J
AU Ferguson, JB
Thao, X
Rohatgi, PK
Cho, K
Kim, CS
AF Ferguson, J. B.
Thao, Xee
Rohatgi, Pradeep K.
Cho, Kyu
Kim, Chang-Soo
TI Computational and analytical prediction of the elastic modulus and yield
stress in particulate-reinforced metal matrix composites
SO SCRIPTA MATERIALIA
LA English
DT Article
DE Finite-element analysis; Mechanical properties; Modeling; Metal matrix
composites
ID MELTED SIC/AL COMPOSITES; BEHAVIOR; MAGNESIUM; STRENGTH; TENSILE; ALLOY;
PM
AB In this work, three-dimensional finite-element analysis (FEA) simulations based on the representative volume element approach have been performed to determine the elastic modulus and yield stress of spherical particle-reinforced metal matrix composites. These simulations take into consideration of the degree of bonding between the matrix and the reinforcement. An analytical model has been developed using the FEA computations, and the results agree well with experimental findings reported in the literature for strongly bonded Al-2080/SiC and poorly bonded Al-2024/Al2O3 materials. (C) 2014 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
C1 [Ferguson, J. B.; Thao, Xee; Rohatgi, Pradeep K.; Kim, Chang-Soo] Univ Wisconsin, Dept Mat Sci & Engn, Milwaukee, WI 53211 USA.
[Cho, Kyu] US Army, Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA.
RP Kim, CS (reprint author), Univ Wisconsin, Dept Mat Sci & Engn, Milwaukee, WI 53211 USA.
EM kimcs@uwm.edu
FU United States Army Research Laboratory [W911NF-08-2-0014]
FX This material is based upon work supported by the United States Army
Research Laboratory under Cooperative Agreement No. W911NF-08-2-0014.
The views, opinions and conclusions made in this document are those of
the authors and should not be interpreted as representing the official
policies, either expressed or implied, of the Army Research Laboratory
or the U.S. Government. The U.S. Government is authorized to reproduce
and distribute reprints for Government purposes notwithstanding any
copyright notation herein.
NR 14
TC 6
Z9 6
U1 3
U2 26
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 1359-6462
J9 SCRIPTA MATER
JI Scr. Mater.
PD JUL 15
PY 2014
VL 83
BP 45
EP 48
DI 10.1016/j.scriptamat.2014.04.004
PG 4
WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary;
Metallurgy & Metallurgical Engineering
SC Science & Technology - Other Topics; Materials Science; Metallurgy &
Metallurgical Engineering
GA AI4IT
UT WOS:000336829600012
ER
PT J
AU Lin, J
Walsh, L
Hughes, G
Woicik, JC
Povey, IM
O'Regan, TP
Hurley, PK
AF Lin, Jun
Walsh, Lee
Hughes, Greg
Woicik, Joseph C.
Povey, Ian M.
O'Regan, Terrance P.
Hurley, Paul K.
TI A combined capacitance-voltage and hard x-ray photoelectron spectroscopy
characterisation of metal/Al2O3/In0.53Ga0.47As capacitor structures
SO JOURNAL OF APPLIED PHYSICS
LA English
DT Article
ID ELECTRICAL-PROPERTIES
AB Capacitance-Voltage (C-V) characterization and hard x-ray photoelectron spectroscopy (HAXPES) measurements have been used to study metal/Al2O3/In0.53Ga0.47As capacitor structures with high (Ni) and low (Al) work function metals. The HAXPES measurements observe a band bending occurring prior to metal deposition, which is attributed to a combination of fixed oxide charges and interface states of donor-type. Following metal deposition, the Fermi level positions at the Al2O3/In0.53Ga0.47As interface move towards the expected direction as observed from HAXPES measurements. The In0.53Ga0.47As surface Fermi level positions determined from both the C-V analysis at zero gate bias and HAXPES measurements are in reasonable agreement. The results are consistent with the presence of electrically active interface states at the Al2O3/In0.53Ga0.47As interface and suggest an interface state density increasing towards the In0.53Ga0.47As valence band edge. (C) 2014 AIP Publishing LLC.
C1 [Lin, Jun; Povey, Ian M.; Hurley, Paul K.] Natl Univ Ireland Univ Coll Cork, Tyndall Natl Inst, Cork, Ireland.
[Walsh, Lee; Hughes, Greg] Dublin City Univ, Sch Phys Sci, Dublin 9, Ireland.
[Woicik, Joseph C.] NIST, Gaithersburg, MD 20899 USA.
[O'Regan, Terrance P.] US Army Res Lab, Adelphi, MD 20783 USA.
RP Lin, J (reprint author), Natl Univ Ireland Univ Coll Cork, Tyndall Natl Inst, Cork, Ireland.
RI Povey, Ian/C-6439-2009;
OI Povey, Ian/0000-0002-7877-6664; Hughes, Greg/0000-0003-1310-8961;
Hughes, Gregory/0000-0002-1358-9032
FU Science Foundation Ireland through INVENT Project [SFI/09/IN.1/I2633];
U.S. Department of Energy, Office of Science, Office of Basic Energy
Sciences [DE-AC02-98CH10886]
FX The authors from Tyndall National Institute and Dublin City University
acknowledge Science Foundation Ireland for financial support of the
research work through the INVENT Project (SFI/09/IN.1/I2633). The
central fabrication facility at Tyndall is acknowledged for the
fabrication of the experimental samples used in this work. Ian Povey
from Tyndall is acknowledged for the ALD growth of the
Al2O3 layers. Dan O'Connell from Tyndall is
acknowledged for the metallisation. Patrick Carolan from Tyndall is
acknowledged for the TEM analysis. Access to the X24A HAXPES beamline at
Brookhaven National Laboratory was obtained through a General User
Proposal. Use of the National Synchrotron Light Source, Brookhaven
National Laboratory, was supported by the U.S. Department of Energy,
Office of Science, Office of Basic Energy Sciences, under Contract No.
DE-AC02-98CH10886.
NR 30
TC 0
Z9 0
U1 0
U2 16
PU AMER INST PHYSICS
PI MELVILLE
PA 1305 WALT WHITMAN RD, STE 300, MELVILLE, NY 11747-4501 USA
SN 0021-8979
EI 1089-7550
J9 J APPL PHYS
JI J. Appl. Phys.
PD JUL 14
PY 2014
VL 116
IS 2
AR 024104
DI 10.1063/1.4887517
PG 8
WC Physics, Applied
SC Physics
GA AN0II
UT WOS:000340267600054
ER
PT J
AU Gust, KA
Najar, FZ
Habib, T
Lotufo, GR
Piggot, AM
Fouke, BW
Laird, JG
Wilbanks, MS
Rawat, A
Indest, KJ
Roe, BA
Perkins, EJ
AF Gust, Kurt A.
Najar, Fares Z.
Habib, Tanwir
Lotufo, Guilherme R.
Piggot, Alan M.
Fouke, Bruce W.
Laird, Jennifer G.
Wilbanks, Mitchell S.
Rawat, Arun
Indest, Karl J.
Roe, Bruce A.
Perkins, Edward J.
TI Coral-zooxanthellae meta-transcriptomics reveals integrated response to
pollutant stress
SO BMC GENOMICS
LA English
DT Article
DE Coral holobiont; Marine pollution; Meta-transcriptomics; Acropora;
Zooxanthellae; RDX; Symbiosis; Transcriptional network; Next generation
sequencing
ID ACROPORA-MILLEPORA; NORTHERN BOBWHITE; HUMAN FOOTPRINT; CLIMATE-CHANGE;
REEF CORALS; RED-SEA; GENOME; ACIDIFICATION; CONSTRUCTION; NETWORKS
AB Background: Corals represent symbiotic meta-organisms that require harmonization among the coral animal, photosynthetic zooxanthellae and associated microbes to survive environmental stresses. We investigated integrated-responses among coral and zooxanthellae in the scleractinian coral Acropora formosa in response to an emerging marine pollutant, the munitions constituent, 1,3,5-trinitro-1,3,5 triazine (RDX; 5 day exposures to 0 (control), 0.5, 0.9, 1.8, 3.7, and 7.2 mg/L, measured in seawater).
Results: RDX accumulated readily in coral soft tissues with bioconcentration factors ranging from 1.1 to 1.5. Next-generation sequencing of a normalized meta-transcriptomic library developed for the eukaryotic components of the A. formosa coral holobiont was leveraged to conduct microarray-based global transcript expression analysis of integrated coral/zooxanthellae responses to the RDX exposure. Total differentially expressed transcripts (DET) increased with increasing RDX exposure concentrations as did the proportion of zooxanthellae DET relative to the coral animal. Transcriptional responses in the coral demonstrated higher sensitivity to RDX compared to zooxanthellae where increased expression of gene transcripts coding xenobiotic detoxification mechanisms (i.e. cytochrome P450 and UDP glucuronosyltransferase 2 family) were initiated at the lowest exposure concentration. Increased expression of these detoxification mechanisms was sustained at higher RDX concentrations as well as production of a physical barrier to exposure through a 40% increase in mucocyte density at the maximum RDX exposure. At and above the 1.8 mg/L exposure concentration, DET coding for genes involved in central energy metabolism, including photosynthesis, glycolysis and electron-transport functions, were decreased in zooxanthellae although preliminary data indicated that zooxanthellae densities were not affected. In contrast, significantly increased transcript expression for genes involved in cellular energy production including glycolysis and electron-transport pathways was observed in the coral animal.
Conclusions: Transcriptional network analysis for central energy metabolism demonstrated highly correlated responses to RDX among the coral animal and zooxanthellae indicative of potential compensatory responses to lost photosynthetic potential within the holobiont. These observations underscore the potential for complex integrated responses to RDX exposure among species comprising the coral holobiont and highlight the need to understand holobiont-species interactions to accurately assess pollutant impacts.
C1 [Gust, Kurt A.; Lotufo, Guilherme R.; Laird, Jennifer G.; Wilbanks, Mitchell S.; Indest, Karl J.; Perkins, Edward J.] US Army Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA.
[Najar, Fares Z.] Univ Oklahoma, Adv Ctr Genome Technol, Norman, OK 73019 USA.
[Habib, Tanwir] Badger Tech Serv, San Antonio, TX 78216 USA.
[Piggot, Alan M.; Fouke, Bruce W.; Roe, Bruce A.] Univ Illinois, Dept Geol, Urbana, IL 31801 USA.
[Piggot, Alan M.] Univ Miami, Div Marine Geol & Geophys, Miami, FL 33149 USA.
[Fouke, Bruce W.] Univ Illinois, Inst Genom Biol, Urbana, IL 61801 USA.
[Rawat, Arun] Translat Genom Res Inst, Phoenix, AZ 85004 USA.
RP Gust, KA (reprint author), US Army Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA.
EM kurt.a.gust@usace.army.mil
OI Rawat, Arun/0000-0003-0540-2044
FU US Navy, Office of Naval Research [N00014-06-1-0135]; U.S. Army,
Environmental Quality Research Program
FX We thank the US Navy, Office of Naval Research for grant support
(N00014-06-1-0135) as well as support from the U.S. Army, Environmental
Quality Research Program, Effects of Munitions Compounds on Biological
Networks Focus Area. We also thank Joan Clarke for consultation on
statistical methods. Permission for publishing this information has been
granted by the Chief of Engineers.
NR 54
TC 5
Z9 5
U1 1
U2 31
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1471-2164
J9 BMC GENOMICS
JI BMC Genomics
PD JUL 12
PY 2014
VL 15
AR 591
DI 10.1186/1471-2164-15-591
PG 18
WC Biotechnology & Applied Microbiology; Genetics & Heredity
SC Biotechnology & Applied Microbiology; Genetics & Heredity
GA AM1DR
UT WOS:000339587100002
PM 25016412
ER
PT J
AU Hartley, DJ
Janssens, RVF
Riedinger, LL
Riley, MA
Wang, X
Miller, S
Ayangeakaa, AD
Carpenter, MP
Carroll, JJ
Cavey, J
Chiara, CJ
Chowdhury, P
Garg, U
Hota, SS
Jackson, EG
Kondev, FG
Lauritsen, T
Litz, M
Ma, WC
Matta, J
Paul, ES
Pedicini, EE
Simpson, J
Vanhoy, JR
Zhu, S
AF Hartley, D. J.
Janssens, R. V. F.
Riedinger, L. L.
Riley, M. A.
Wang, X.
Miller, S.
Ayangeakaa, A. D.
Carpenter, M. P.
Carroll, J. J.
Cavey, J.
Chiara, C. J.
Chowdhury, P.
Garg, U.
Hota, S. S.
Jackson, E. G.
Kondev, F. G.
Lauritsen, T.
Litz, M.
Ma, W. C.
Matta, J.
Paul, E. S.
Pedicini, E. E.
Simpson, J.
Vanhoy, J. R.
Zhu, S.
TI High-spin structure of odd-odd Re-172
SO PHYSICAL REVIEW C
LA English
DT Article
AB A significant extension of the level scheme for the odd-odd nucleus Re-172 was accomplished through the use of the Gammasphere spectrometer. States up to a tentative spin assignment of 39 were observed and two new structures were identified. Configuration assignments are proposed based on alignment properties and observed band crossings.
C1 [Hartley, D. J.; Cavey, J.; Pedicini, E. E.; Vanhoy, J. R.] US Naval Acad, Dept Phys, Annapolis, MD 21402 USA.
[Janssens, R. V. F.; Carpenter, M. P.; Chiara, C. J.; Lauritsen, T.; Zhu, S.] Argonne Natl Lab, Div Phys, Argonne, IL 60439 USA.
[Riedinger, L. L.] Univ Tennessee, Dept Phys & Astron, Knoxville, TN 37996 USA.
[Riley, M. A.; Wang, X.; Miller, S.] Florida State Univ, Dept Phys, Tallahassee, FL 32306 USA.
[Ayangeakaa, A. D.; Garg, U.; Matta, J.] Univ Notre Dame, Dept Phys, Notre Dame, IN 46556 USA.
[Carroll, J. J.; Litz, M.] Army Res Lab, Adelphi, MD 20783 USA.
[Chiara, C. J.] Univ Maryland, Dept Chem & Biochem, College Pk, MD 20742 USA.
[Chiara, C. J.; Kondev, F. G.] Argonne Natl Lab, Nucl Engn Div, Argonne, IL 60439 USA.
[Chowdhury, P.; Hota, S. S.; Jackson, E. G.] Univ Massachusetts, Dept Phys, Lowell, MA 01854 USA.
[Ma, W. C.] Mississippi State Univ, Dept Phys, Mississippi State, MS 39762 USA.
[Paul, E. S.] Univ Liverpool, Oliver Lodge Lab, Liverpool L69 7ZE, Merseyside, England.
[Simpson, J.] STFC Daresbury Lab, Warrington WA4 4AD, Cheshire, England.
RP Hartley, DJ (reprint author), US Naval Acad, Dept Phys, Annapolis, MD 21402 USA.
RI Carpenter, Michael/E-4287-2015; Ayangeakaa, Akaa/F-3683-2015
OI Carpenter, Michael/0000-0002-3237-5734; Ayangeakaa,
Akaa/0000-0003-1679-3175
FU National Science Foundation [PHY-1203100, PHY-0754674, PHY-1068192];
U.S. Department of Energy, Office of Nuclear Physics [DE-AC02-06CH11357,
DE-FG02-94ER40848, DE-FG02-96ER40983, DE-FG02-94ER40834,
DE-FG02-95ER40939]; United Kingdom Science and Technology Facilities
Council
FX The authors thank the ANL operations staff at Gammasphere and gratefully
acknowledge the efforts of J. P. Greene for target preparation. We thank
D. C. Radford and H. Q. Jin for their software support. This work is
funded by the National Science Foundation under Grants No. PHY-1203100
(USNA), No. PHY-0754674 (FSU), and No. PHY-1068192 (ND), as well as by
the U.S. Department of Energy, Office of Nuclear Physics, under
Contracts No. DE-AC02-06CH11357 (ANL), No. DE-FG02-94ER40848 (UML), No.
DE-FG02-96ER40983 (UT), No. DE-FG02-94ER40834 (UMCP), and No.
DE-FG02-95ER40939 (MSU), as well as the United Kingdom Science and
Technology Facilities Council.
NR 14
TC 2
Z9 2
U1 3
U2 7
PU AMER PHYSICAL SOC
PI COLLEGE PK
PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA
SN 0556-2813
EI 1089-490X
J9 PHYS REV C
JI Phys. Rev. C
PD JUL 11
PY 2014
VL 90
IS 1
AR 017301
DI 10.1103/PhysRevC.90.017301
PG 5
WC Physics, Nuclear
SC Physics
GA AQ7MQ
UT WOS:000343002300010
ER
PT J
AU Taylor, DE
Strawhecker, KE
Shanholtz, ER
Sorescu, DC
Sausa, RC
AF Taylor, D. E.
Strawhecker, K. E.
Shanholtz, E. R.
Sorescu, D. C.
Sausa, R. C.
TI Investigations of the Intermolecular Forces between RDX and Polyethylene
by Force-Distance Spectroscopy and Molecular Dynamics Simulations
SO JOURNAL OF PHYSICAL CHEMISTRY A
LA English
DT Article
ID PLASTIC-BONDED EXPLOSIVES; SURFACE-ENERGY; CRYSTAL-STRUCTURE;
CYCLOTRIMETHYLENE-TRINITRAMINE; DENSITY POLYETHYLENE; ADHESION;
MICROSCOPE; PARTICLES; PHASE; HMX
AB The development of novel nanoenergetic materials with enhanced bulk properties requires an understanding of the intermolecular interactions occurring between molecular components. We investigate the surface interactions between 1,3,5-trinitro-1,3,5-triazacyclohexane (RDX) and polyethylene (PE) crystals on the basis of combined use of molecular dynamics (MD) simulations and force-distance spectroscopy, in conjunction with Lifshitz macroscopic theory of van der Waals forces between continuous materials. The binding energy in the RDX-PE system depends both on the degree of PE crystallinity and on the RDX crystal face. Our MD simulations yield binding energies of approximately 132 and 120 mJ/m(2) for 100% amorphous and 100% crystalline PE on RDX (210), respectively. The average value is about 36% greater than our experimental value of 81 +/- 15 mJ/m(2) for PE (similar to 48% amorphous) on RDX (210). By comparison, Liftshitz theory predicts a value of about 79 mJ/m(2) for PE interacting with RDX. Our MD simulations also predict larger binding energies for both amorphous and crystalline PE on RDX (210) compared to the RDX (001) surface. Analysis of the interaction potential indicates that about 60% of the binding energy in the PE-RDX system is due to attractive interactions between H-PE-O-RDX and C-PE-N-RDX pairs of atoms. Further, amorphous PE shows a much longer interaction distance than crystalline PE with the (210) and (001) RDX surfaces due to the possibility of larger polymer elongations in the case of amorphous PE as strain is applied. Also, we report estimates of the binding energies of energetic materials RDX and octahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocine (HMX) with PE, propylene, polystyrene, and several fluorine-containing polymers using Lifshitz theory and compare these with reported MD calculations.
C1 [Taylor, D. E.; Sausa, R. C.] Army Res Lab, ARL RDL WML B, Aberdeen Proving Ground, MD 21005 USA.
[Strawhecker, K. E.] Army Res Lab, ARL RDL WMM EG, Aberdeen Proving Ground, MD 21005 USA.
[Shanholtz, E. R.] Army Res Lab, ARL RDL WMM EUS, Aberdeen Proving Ground, MD 21005 USA.
[Sorescu, D. C.] US DOE, Natl Energy Technol Lab, Pittsburgh, PA 15236 USA.
[Sorescu, D. C.] Univ Pittsburgh, Dept Chem & Petr Engn, Pittsburgh, PA 15261 USA.
RP Sausa, RC (reprint author), Army Res Lab, ARL RDL WML B, Aberdeen Proving Ground, MD 21005 USA.
EM rosario.c.sausa.civ@mail.mil
FU ARL Multiscale Response of Energetic Materials Program; ARL-Oak Ridge
Institute for Science and Education Program
FX We thank Drs. R. Pesce-Rodriquez of the Army Research Laboratory (ARL)
and K. Behler of ARL-Bowhead Science & Technology for many helpful
discussions, and Dr. K. Ramos of the Los Alamos National Laboratory for
providing us with the RDX crystals. Support from the ARL Multiscale
Response of Energetic Materials Program and the ARL-Oak Ridge Institute
for Science and Education Program is gratefully acknowledged. We also
acknowledge with thanks a supercomputing challenge grant at several DOD
Supercomputing Resource Centers (DSRCs).
NR 69
TC 1
Z9 1
U1 4
U2 46
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 1089-5639
J9 J PHYS CHEM A
JI J. Phys. Chem. A
PD JUL 10
PY 2014
VL 118
IS 27
BP 5083
EP 5097
DI 10.1021/jp5039317
PG 15
WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical
SC Chemistry; Physics
GA AL2UK
UT WOS:000338980800024
PM 24922563
ER
PT J
AU Hlepas, G
Truster, T
Masud, A
AF Hlepas, Georgette
Truster, Timothy
Masud, Arif
TI A heterogeneous modeling method for porous media flows
SO INTERNATIONAL JOURNAL FOR NUMERICAL METHODS IN FLUIDS
LA English
DT Article
DE multiscale methods; variational methods; heterogeneous methods; Darcy
flow; Darcy-Stokes flow
ID FINITE-ELEMENT-METHOD; VARIATIONAL MULTISCALE METHOD; DARCY FLOW;
STABILIZED METHODS; SOURCE TERMS; FORMULATION; FRAMEWORK; MECHANICS;
EQUATIONS; BUBBLES
AB This paper presents a new heterogeneous multiscale modeling method for porous media flows. Physics at the global level is governed by one set of PDEs, while features in the solution that are beyond the resolution capacity of the global model are accounted for by the next refined set of governing equations. In this method, the global or coarse model is given by the Darcy equation, while the local or refined model is given by the Darcy-Stokes equation. Concurrent domain decomposition where global and local models are applied to adjacent subdomains, as well as overlapping domain decomposition where global and local models coexist on overlapping domains, is considered. An interface operator is developed for the case where global and local models commute along the common interface. For the overlapping decomposition, a residual-based coupling technique is developed that consistently facilitates bottom-up embedding of scale effects from the local Darcy-Stokes model into the global Darcy model. Numerical results are presented for nonoverlapping and overlapping domain decompositions for various benchmark problems. Computed results show that the hierarchically coupled models accurately account for the heterogeneity of the medium and efficiently incorporate local features into the global response. Copyright (c) 2014 John Wiley & Sons, Ltd.
C1 [Hlepas, Georgette] US Army Corps Engineers, Chicago, IL 60606 USA.
[Hlepas, Georgette] Univ Illinois, Dept Civil & Mat Engn, Chicago, IL 60612 USA.
[Truster, Timothy] Univ Tennessee, Dept Civil & Environm Engn, Knoxville, TN 37996 USA.
[Truster, Timothy; Masud, Arif] Univ Illinois, Dept Civil & Environm Engn, Urbana, IL 61801 USA.
RP Masud, A (reprint author), Univ Illinois, Dept Civil & Environm Engn, Urbana, IL 61801 USA.
EM amasud@illinois.edu
FU Department of Defense SMART scholarship program; NSF Graduate Research
Fellowship
FX G. Hlepas was supported by the Department of Defense SMART scholarship
program. T. Truster was sponsored by an NSF Graduate Research
Fellowship. These supports are gratefully acknowledged.
NR 35
TC 2
Z9 2
U1 0
U2 6
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0271-2091
EI 1097-0363
J9 INT J NUMER METH FL
JI Int. J. Numer. Methods Fluids
PD JUL 10
PY 2014
VL 75
IS 7
BP 487
EP 518
DI 10.1002/fld.3904
PG 32
WC Computer Science, Interdisciplinary Applications; Mathematics,
Interdisciplinary Applications; Mechanics; Physics, Fluids & Plasmas
SC Computer Science; Mathematics; Mechanics; Physics
GA AJ2ZL
UT WOS:000337534100002
ER
PT J
AU Taylor, G
Hipp, D
Moser, A
Dickerson, K
Gerhardstein, P
AF Taylor, Gemma
Hipp, Daniel
Moser, Alecia
Dickerson, Kelly
Gerhardstein, Peter
TI The development of contour processing: evidence from physiology and
psychophysics
SO FRONTIERS IN PSYCHOLOGY
LA English
DT Review
DE contour detection; closure; horizontal connections; development; visual
development
ID PRIMARY VISUAL-CORTEX; YOUNG INFANTS PERCEPTION; MONKEY STRIATE CORTEX;
TOP-DOWN INFLUENCES; LATERAL INTERACTIONS; FUNCTIONAL ARCHITECTURE;
CONTEXTUAL INTERACTIONS; SPATIAL INTEGRATION; INTRINSIC CONNECTIONS;
CONTRAST SENSITIVITY
AB Object perception and pattern vision depend fundamentally upon the extraction of contours from the visual environment. In adulthood, contour or edge-level processing is supported by the Gestalt heuristics of proximity, collinearity, and closure. Less is known, however, about the developmental trajectory of contour detection and contour integration. Within the physiology of the visual system, long-range horizontal connections in V1 and V2 are the likely candidates for implementing these heuristics. While post-mortem anatomical studies of human infants suggest that horizontal interconnections reach maturity by the second year of life, psychophysical research with infants and children suggests a considerably more protracted development. In the present review, data from infancy to adulthood will be discussed in order to track the development of contour detection and integration. The goal of this review is thus to integrate the development of contour detection and integration with research regarding the development of underlying neural circuitry. We conclude that the ontogeny of this system is best characterized as a developmentally extended period of associative acquisition whereby horizontal connectivity becomes functional over longer and longer distances, thus becoming able to effectively integrate over greater spans of visual space.
C1 [Taylor, Gemma; Hipp, Daniel; Moser, Alecia; Gerhardstein, Peter] SUNY Binghamton, Dept Psychol, Binghamton, NY 13902 USA.
[Dickerson, Kelly] RDRL HRS D, Dept Army, US Army Res Lab, Aberdeen Proving Ground, MD USA.
RP Gerhardstein, P (reprint author), SUNY Binghamton, Dept Psychol, Binghamton, NY 13902 USA.
EM gerhard@binghamton.edu
OI Taylor, Gemma/0000-0002-0988-7168
NR 115
TC 1
Z9 1
U1 3
U2 25
PU FRONTIERS RESEARCH FOUNDATION
PI LAUSANNE
PA PO BOX 110, LAUSANNE, 1015, SWITZERLAND
SN 1664-1078
J9 FRONT PSYCHOL
JI Front. Psychol.
PD JUL 8
PY 2014
VL 5
DI 10.3389/fpsyg.2014.00719
PG 10
WC Psychology, Multidisciplinary
SC Psychology
GA AL2HY
UT WOS:000338947800001
ER
PT J
AU Jackson, AC
Walck, SD
Strawhecker, KE
Butler, BG
Lambeth, RH
Beyer, FL
AF Jackson, Aaron C.
Walck, Scott D.
Strawhecker, Kenneth E.
Butler, Brady G.
Lambeth, Robert H.
Beyer, Frederick L.
TI Metallopolymers Containing Excess Metal-Ligand Complex for Improved
Mechanical Properties
SO MACROMOLECULES
LA English
DT Article
ID INDUCED SUPRAMOLECULAR POLYMERIZATION; HYDROGEN-BONDING INTERACTIONS;
SMALL-ANGLE SCATTERING; PI-PI STACKING; COORDINATION POLYMERS;
SELF-ORGANIZATION; CHAIN
AB This work incorporates ML complexes as unbound entities that interact with ML complexes bound to the backbone of the polymer. The pi-pi interactions and Coulombic forces between bound and unbound ML complexes hold the ML-rich phase together and result in improved mechanical properties over polymers containing only the bound ML complexes. The ML-rich phase formed ordered, cylindrical domains. The storage modulus, surface elastic modulus, and high temperature stability of these metallopolymers increased with increasing concentration of ML complex in the polymer while an optimal concentration and morphology are necessary to improve the strength and creep resistance of the polymer. Ultimately, the successful addition and patterning of unbound ML complexes as a hard phase in a polymer matrix provides an important template for the design of a new type of supramolecular nanocomposite.
C1 [Jackson, Aaron C.; Walck, Scott D.; Strawhecker, Kenneth E.; Butler, Brady G.; Lambeth, Robert H.; Beyer, Frederick L.] US Army Res Lab, Weap & Mat Res Directorate, Aberdeen, MD 21005 USA.
RP Jackson, AC (reprint author), US Army Res Lab, Weap & Mat Res Directorate, Aberdeen, MD 21005 USA.
EM aa.jckson@gmail.com
FU Postgraduate Research Participation Program at the US Army Research
Laboratory [ORISE 1120-1120-99]
FX A.C.J. is supported by the Postgraduate Research Participation Program
at the US Army Research Laboratory, administered by the Oak Ridge
Institute of Science and Education through an interagency agreement
between the US Department of Energy and Army Research Laboratory
(Contract ORISE 1120-1120-99).
NR 45
TC 6
Z9 6
U1 1
U2 26
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0024-9297
EI 1520-5835
J9 MACROMOLECULES
JI Macromolecules
PD JUL 8
PY 2014
VL 47
IS 13
BP 4144
EP 4150
DI 10.1021/ma500516p
PG 7
WC Polymer Science
SC Polymer Science
GA AL0GW
UT WOS:000338806400003
ER
PT J
AU Anderson, EM
Lundquist, AM
Sarney, WL
Svensson, SP
Carrington, PJ
Pearson, C
Millunchick, JM
AF Anderson, Evan M.
Lundquist, Adam M.
Sarney, Wendy L.
Svensson, Stefan P.
Carrington, Peter J.
Pearson, Chris
Millunchick, Joanna M.
TI Influence of a Bi surfactant on Sb incorporation in InAsSb alloys
SO JOURNAL OF APPLIED PHYSICS
LA English
DT Article
ID MOLECULAR-BEAM EPITAXY; BISMUTH SURFACTANT; GROWTH
AB The influence of using a Bi surfactant during the growth of InAsSb on the composition was examined, and it was found that increasing Bi flux on the surface during growth inhibits the incorporation of Sb. Analysis of the data via a kinetic model of anion incorporation shows that surface Bi acts as a catalyst for InAs formation, thus inhibiting Sb incorporation. (C) 2014 AIP Publishing LLC.
C1 [Anderson, Evan M.; Lundquist, Adam M.; Millunchick, Joanna M.] Univ Michigan, Dept Mat Sci & Engn, Ann Arbor, MI 48109 USA.
[Sarney, Wendy L.; Svensson, Stefan P.] US Army Res Lab, Sensors & Elect Devices Directorate, Adelphi, MD 20783 USA.
[Carrington, Peter J.] UCL, Dept Elect & Elect Engn, London WC1E 7JE, England.
[Pearson, Chris] Univ Michigan, Dept Comp Sci Engn & Phys, Flint, MI 48502 USA.
RP Anderson, EM (reprint author), Univ Michigan, Dept Mat Sci & Engn, Ann Arbor, MI 48109 USA.
OI Anderson, Evan/0000-0002-3771-3085; Carrington,
Peter/0000-0003-2107-5602
FU Department of Defense, Army Research Office [W911NF-12-1-0338]
FX E.M.A., A.M.L., C.P., and J.M.M. gratefully acknowledge Chakrapani
Varanasi and the support of the Department of Defense, Army Research
Office via the Grant No. W911NF-12-1-0338.
NR 15
TC 4
Z9 4
U1 2
U2 13
PU AMER INST PHYSICS
PI MELVILLE
PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1,
MELVILLE, NY 11747-4501 USA
SN 0021-8979
EI 1089-7550
J9 J APPL PHYS
JI J. Appl. Phys.
PD JUL 7
PY 2014
VL 116
IS 1
AR 014901
DI 10.1063/1.4886635
PG 4
WC Physics, Applied
SC Physics
GA AM1QB
UT WOS:000339621400063
ER
PT J
AU Moretti, JD
Sabatini, JJ
Poret, JC
AF Moretti, Jared D.
Sabatini, Jesse J.
Poret, Jay C.
TI High-Performing Red-Light-Emitting Pyrotechnic Illuminants through the
Use of Perchlorate-Free Materials
SO CHEMISTRY-A EUROPEAN JOURNAL
LA English
DT Article
DE formulations; green chemistry; illuminants; potassium; pyrotechnics
ID CIVILIAN APPLICATIONS; PERIODATE SALTS; NITROGEN; MILITARY
AB The development of perchlorate-free M662 40 mm illuminating pyrotechnic compositions is described. On the bases of cost, performance, and sensitivity, potassium periodate was determined to be most effective potassium perchlorate replacement in the compositions tested. The optimal periodate-based composition exceeded the performance of the perchlorate-containing control, exhibited low sensitivity values to impact, friction, and electrostatic discharge, and had high thermal onset temperatures.
C1 [Moretti, Jared D.; Sabatini, Jesse J.; Poret, Jay C.] US Army, Pyrotech Technol & Prototyping Div, RDECOM ARDEC, Picatinny Arsenal, NJ 07806 USA.
RP Sabatini, JJ (reprint author), US Army, Pyrotech Technol & Prototyping Div, RDECOM ARDEC, Picatinny Arsenal, NJ 07806 USA.
EM jesse.j.sabatini.civ@mail.mil
FU US Army
FX The authors thank Dr. Karl Oyler (ARDEC) for acquiring particle size
information of all relevant ingredients, and express their gratitude to
Mr. Henry A. Grau (ARDEC) for providing thermal onset data. The efforts
by Mr. Eric A. Latalladi (ARDEC) and Mr. Stephen C. Taggart (ARDEC) for
their assistance in the preparation of pyrotechnic mixes are greatly
appreciated. The authors are indebted to the US Army for funding of this
work.
NR 29
TC 5
Z9 5
U1 0
U2 6
PU WILEY-V C H VERLAG GMBH
PI WEINHEIM
PA BOSCHSTRASSE 12, D-69469 WEINHEIM, GERMANY
SN 0947-6539
EI 1521-3765
J9 CHEM-EUR J
JI Chem.-Eur. J.
PD JUL 7
PY 2014
VL 20
IS 28
BP 8800
EP 8804
DI 10.1002/chem.201402654
PG 5
WC Chemistry, Multidisciplinary
SC Chemistry
GA AK9TC
UT WOS:000338768900040
PM 24939042
ER
PT J
AU Wang, XY
Bynum, JA
Stavchansky, S
Bowman, PD
AF Wang, Xinyu
Bynum, James A.
Stavchansky, Solomon
Bowman, Phillip D.
TI Cytoprotection of human endothelial cells against oxidative stress by
1-[2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oyl]imidazole (CDDO-Im):
Application of systems biology to understand the mechanism of action
SO EUROPEAN JOURNAL OF PHARMACOLOGY
LA English
DT Article
DE CDDO-Im; CAPE; Cytoprotection; Oxidative stress; Heme oxygenase-1; Gene
expression analysis
ID ACID PHENETHYL ESTER; HEME OXYGENASE-1;
2-CYANO-3,12-DIOXOOLEAN-1,9-DIEN-28-OIC ACID; SIGNAL-TRANSDUCTION;
INDUCTION; IMIDAZOLIDE; APOPTOSIS; INDUCERS; CANCER; INJURY
AB Cellular damage horn oxidative stress, in particular following ischemic injury, occurs during heart attack, stroke, or traumatic injury, and is potentially reducible with appropriate drug treatment. We previously reported that caffeic acid phenethyl ester (CAPE), a plant-derived polyphenolic compound, protected human umbilical vein endothelial cells (HUVEC) from menadione-induced oxidative stress and that this cytoprotective effect was correlated with the capacity to induce home oxygenase-1 (HMOX1) and its protein product, a phase It cytoprotective enzyme. To further improve this cytoprotective effect, we studied a synthetic triterpenoid,1-[2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oyl[imidazole (CDDO-Im), which is known as a potent phase II enzyme inducer with antitumor and anti-inflammatory activities, and compared it to CAPE. CDDO-Im at 200 nM provided more protection to HUVEC against oxidative stress than 20 mu M CAPE. We explored the mechanism of CDDO-Im cytoprotection with gene expression profiling and pathway analysis and compared to that of CAPE. In addition to potent up-regulation of HMOX1, heat shock proteins (HSP) were also found to be highly induced by CDDO-Im in HUVEC. Pathway analysis results showed that transcription factor Nrf2-mediated oxidative stress response was among the top canonical pathways commonly activated by both CDDO-Im and CAPE. Compared to CAPE, CDDO-Im up-regulated more HSP and some of them to a much higher extent. In addition, CDDO-Im treatment affected Nrf2 pathway more significantly. These findings may provide an explanation why CDDO-Im is a more potent cytoprotectant than CAPE against oxidative stress in HUVEC. (C) 2014 Elsevier B.V. All rights reserved
C1 [Wang, Xinyu] Philadelphia Coll Osteopath Med, Sch Pharm, Dept Pharmaceut Sci, Suwanee, GA 30024 USA.
[Bynum, James A.; Bowman, Phillip D.] US Army, Inst Surg Res, Ft Sam Houston, TX 78234 USA.
[Bynum, James A.; Stavchansky, Solomon] Univ Texas Austin, Coll Pharm, Div Pharmaceut, Austin, TX 77812 USA.
RP Wang, XY (reprint author), Philadelphia Coll Osteopath Med, Sch Pharm, Dept Pharmaceut Sci, Georgia Campus,625 Old Peachtree Rd NW, Suwanee, GA 30024 USA.
EM xinyuwa@pcom.edu; phillip.d.bowman4.vol@mail.mil
NR 30
TC 3
Z9 4
U1 1
U2 13
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0014-2999
EI 1879-0712
J9 EUR J PHARMACOL
JI Eur. J. Pharmacol.
PD JUL 5
PY 2014
VL 734
BP 122
EP 131
DI 10.1016/j.ejphar.2014.03.033
PG 10
WC Pharmacology & Pharmacy
SC Pharmacology & Pharmacy
GA AH8YC
UT WOS:000336423100016
PM 24703885
ER
PT J
AU Ahmad, F
Amin, MG
Dogaru, T
AF Ahmad, Fauzia
Amin, Moeness G.
Dogaru, Traian
TI Partially sparse imaging of stationary indoor scenes
SO EURASIP JOURNAL ON ADVANCES IN SIGNAL PROCESSING
LA English
DT Article
DE Sparse reconstruction; Partial sparsity; Compressive sensing;
Through-the-wall radar
ID SYNTHETIC-APERTURE RADAR; BUILDING INTERIOR; MATCHING PURSUIT; SIGNAL
RECOVERY; WALL; ALGORITHM; DESIGN; MODEL
AB In this paper, we exploit the notion of partial sparsity for scene reconstruction associated with through-the-wall radar imaging of stationary targets under reduced data volume. Partial sparsity implies that the scene being imaged consists of a sparse part and a dense part, with the support of the latter assumed to be known. For the problem at hand, sparsity is represented by a few stationary indoor targets, whereas the high scene density is defined by exterior and interior walls. Prior knowledge of wall positions and extent may be available either through building blueprints or from prior surveillance operations. The contributions of the exterior and interior walls are removed from the data through the use of projection matrices, which are determined from wall- and corner-specific dictionaries. The projected data, with enhanced sparsity, is then processed using l (1) norm reconstruction techniques. Numerical electromagnetic data is used to demonstrate the effectiveness of the proposed approach for imaging stationary indoor scenes using a reduced set of measurements.
C1 [Ahmad, Fauzia; Amin, Moeness G.] Villanova Univ, Ctr Adv Commun, Radar Imaging Lab, Villanova, PA 19085 USA.
[Dogaru, Traian] US Army Res Lab, Adelphi, MD 20783 USA.
RP Ahmad, F (reprint author), Villanova Univ, Ctr Adv Commun, Radar Imaging Lab, Villanova, PA 19085 USA.
EM fauzia.ahmad@villanova.edu
FU ARL [W911NF-11-1-0536]; ARO
FX This work is supported by ARO and ARL under contract W911NF-11-1-0536.
NR 52
TC 0
Z9 0
U1 3
U2 12
PU SPRINGER INTERNATIONAL PUBLISHING AG
PI CHAM
PA GEWERBESTRASSE 11, CHAM, CH-6330, SWITZERLAND
SN 1687-6180
J9 EURASIP J ADV SIG PR
JI EURASIP J. Adv. Signal Process.
PD JUL 4
PY 2014
AR 100
DI 10.1186/1687-6180-2014-100
PG 15
WC Engineering, Electrical & Electronic
SC Engineering
GA AM6EJ
UT WOS:000339955500001
ER
PT J
AU Jain, RB
AF Jain, Ram B.
TI Impact of pregnancy on the concentrations of selected phthalates
SO TOXICOLOGICAL AND ENVIRONMENTAL CHEMISTRY
LA English
DT Article
DE high molecular weight phthalates; low molecular weight phthalates;
diethyhexyl phthalates; pregnancy
ID NUTRITION EXAMINATION SURVEY; NATIONAL-HEALTH; METABOLITE
CONCENTRATIONS; URINARY LEVELS; URBAN COHORT; OLD DATA; EXPOSURE; WOMEN;
CHILDREN; ASSOCIATION
AB Developing fetus can be exposed to toxicants during pregnancy. Impact of human pregnancy on the concentrations of phthalate metabolites mono(carboxynonyl) (MCNP), mono(carboxyoctyl) (MCOP), mono-2-ethyl-5-carboxypentyl, mono-n-butyl, mono-(3-carboxy propyl), monoethyl, mono-2-ethyl-5-hydroxyhexyl, mono-2-ethylhexyl, monoisobutyl, mono-2-ethyl-5-oxohexyl phthalate, mono-benzyl, sum of low molecular weight phthalates ( n-ary sumation LMW), sum of high molecular weight phthalates ( n-ary sumation HMW), and sum of diethylhexyl phthalates was assessed. Data from the National Health and Nutrition Examination Survey for the years 2005-2010 were used for this purpose. Regression models with logs of these metabolites as dependent variables and age, race/ethnicity, education, pregnancy, smoking and iron storage status, study year, family poverty income ratio (PIR), body mass index, urine albumin, and urine creatinine as independent variables were fitted. Pregnant females were found to have significantly lower concentrations of n-ary sumation HMW and MCNP than non-pregnant females. Concentrations of n-ary sumation LMW during the third trimester of pregnancy were significantly lower than during the second trimester of pregnancy.
C1 [Jain, Ram B.] Womack Army Med Ctr, Ft Bragg, NC 28307 USA.
[Jain, Ram B.] Empiristat Inc, Mt Airy, MD USA.
RP Jain, RB (reprint author), Womack Army Med Ctr, Ft Bragg, NC 28307 USA.
EM ram.b.jain.ctr@mail.mil
NR 37
TC 0
Z9 0
U1 1
U2 2
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
SN 0277-2248
EI 1029-0486
J9 TOXICOL ENVIRON CHEM
JI Toxicol Environ. Chem.
PD JUL 3
PY 2014
VL 96
IS 6
BP 962
EP 980
DI 10.1080/02772248.2014.982121
PG 19
WC Environmental Sciences; Toxicology
SC Environmental Sciences & Ecology; Toxicology
GA AX8JS
UT WOS:000347156500014
ER
PT J
AU Lesch, V
Jeremias, S
Moretti, A
Passerini, S
Heuer, A
Borodin, O
AF Lesch, Volker
Jeremias, Sebastian
Moretti, Arianna
Passerini, Stefano
Heuer, Andreas
Borodin, Oleg
TI A Combined Theoretical and Experimental Study of the Influence of
Different Anion Ratios on Lithium Ion Dynamics in Ionic Liquids
SO JOURNAL OF PHYSICAL CHEMISTRY B
LA English
DT Article
ID TRANSPORT-PROPERTIES; RAMAN-SPECTROSCOPY; SALT-SOLUTIONS; ELECTROLYTES;
SIMULATION; MIXTURES; SOLVENTS; FUTURE
AB In this paper, we investigate via experimental and simulation techniques the transport properties, in terms of total ionic conductivity and ion diffusion coefficients, of ionic liquids doped with lithium salts. They are composed of two anions, bis(fluorosulfonyl)imide (FSI) and bis(trifluoromethanesulfonyl)imide (TFSI), and two cations, N-ethyl-N-methylimidazolium (emim) and lithium ions. The comparison of the experimental results with the simulations shows very good agreement over a wide temperature range and a broad range of compositions. The addition of TFSI gives rise to the formation of lithium dimers (Li+-TFSF--Li+). A closer analysis of such dimers shows that involved lithium ions move nearly as fast as single lithium ions, although they have a different coordination and much slower TFSI exchange rates.
C1 [Lesch, Volker; Jeremias, Sebastian; Moretti, Arianna; Heuer, Andreas] Univ Munster, Inst Phys Chem, D-48149 Munster, Germany.
[Passerini, Stefano] Karlsruhe Inst Technol, Helmholtz Inst Ulm, D-52425 Ulm, Germany.
[Borodin, Oleg] US Army Res Lab, Elect Branch, Sensors & Elect Devices Directorate, Adelphi, MD 20783 USA.
RP Lesch, V (reprint author), Univ Munster, Inst Phys Chem, Corrensstr 28-30, D-48149 Munster, Germany.
EM volkerlesch@wwu.de; stefano.passerini@kit.edu; andheuer@wwu.de
RI Passerini, Stefano/A-3859-2015; Borodin, Oleg/B-6855-2012
OI Passerini, Stefano/0000-0002-6606-5304; Borodin,
Oleg/0000-0002-9428-5291
FU BMBF [Forderkennzeichen: 03X4634A, Forderkennzeichen: 03X4631N]
FX S.J., A.M., and S.P. would like to thank the financial support of BMBF
within the project "MEET Hi-END - Materialien und Komponenten fur
Batterien mit hoher Energiedichte" (Forderkennzeichen: 03X4634A). The
work is financially supported by the SafeBatt project from BMBF
(Forderkennzeichen: 03X4631N).
NR 32
TC 23
Z9 23
U1 1
U2 40
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 1520-6106
J9 J PHYS CHEM B
JI J. Phys. Chem. B
PD JUL 3
PY 2014
VL 118
IS 26
BP 7367
EP 7375
DI 10.1021/jp501075g
PG 9
WC Chemistry, Physical
SC Chemistry
GA AK8QL
UT WOS:000338693000016
PM 24905999
ER
PT J
AU Biggins, JB
Kang, HS
Ternei, MA
DeShazer, D
Brady, SF
AF Biggins, John B.
Kang, Hahk-Soo
Ternei, Melinda A.
DeShazer, David
Brady, Sean F.
TI The Chemical Arsenal of Burkholderia pseudomallei Is Essential for
Pathogenicity
SO JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
LA English
DT Article
ID NATURAL-PRODUCT DISCOVERY; LIPOPEPTIDE BIOSURFACTANTS;
PSEUDOMONAS-AERUGINOSA; VIRULENCE FACTORS; PROTEASOME; GENOME;
MELIOIDOSIS; GENE; BIOSYNTHESIS; AVIRULENT
AB Increasing evidence has shown that small-molecule chemistry in microbes (i.e., secondary metabolism) can modulate the microbe-host response in infection and pathogenicity. The bacterial disease melioidosis is conferred by the highly virulent, antibiotic-resistant pathogen Burkholderia pseudomallei (BP). Whereas some macromolecular structures have been shown to influence BP virulence (e.g., secretion systems, cellular capsule, pill), the role of the large cryptic secondary metabolome encoded within its genome has been largely unexplored for its importance to virulence. Herein we demonstrate that BP-encoded small-molecule biosynthesis is indispensible for in vivo BP pathogenicity. Promoter exchange experiments were used to induce high-level molecule production from two gene dusters (MPN and SYR) found to be essential for in vivo virulence. NMR structural characterization of these metabolites identified a new class of lipopeptide biosurfactants/biofilm modulators (the malleipeptins) and syrbactin-type proteasome inhibitors, both of which represent overlooked small-molecule virulence factors for BP. Disruption of Burkholderia virulence by inhibiting the biosynthesis of these small-molecule biosynthetic pathways may prove to be an effective strategy for developing novel melioidosis-specific therapeutics.
C1 [Biggins, John B.; Kang, Hahk-Soo; Ternei, Melinda A.; Brady, Sean F.] Rockefeller Univ, Howard Hughes Med Inst, Lab Genet Encoded Small Mol, New York, NY 10065 USA.
[DeShazer, David] US Army, Bacteriol Div, Med Res Inst Infect Dis, Frederick, MD 21702 USA.
RP Brady, SF (reprint author), Rockefeller Univ, Howard Hughes Med Inst, Lab Genet Encoded Small Mol, 1230 York Ave, New York, NY 10065 USA.
EM sbrady@rockefeller.edu
OI Biggins, John B./0000-0002-0825-3593
FU Northeast Biodefense Center [U54-A1057158]; NIH [GM077516]; Defense
Threat Reduction Agency (DTRA)/Joint Science and Technology Office for
Chemical and Biological Defense (JSTO-CBD) [CBCALL12-LS1-2-0070]
FX This work was supported by Northeast Biodefense Center (U54-A1057158, to
S.F.B), NIH (GM077516, to S.F.B), and the Defense Threat Reduction
Agency (DTRA)/Joint Science and Technology Office for Chemical and
Biological Defense (JSTO-CBD, proposal no. CBCALL12-LS1-2-0070, to
D.D.). Opinions, interpretations, conclusions, and recommendations are
those of the authors and are not necessarily endorsed by the U.S. Army.
We thank Eugene Blue for assistance in conducting the mouse experiments,
and Steven Kern for statistical support. Strain Bp82 was graciously
provided to us Prof. Herbert Schweizer (Colorado State University).
Support was provided by the following Resource Centers of The
Rockefeller University: Proteomics (mass spectrometry) and
High-Throughput and Spectroscopy (NMR facilities).
NR 35
TC 9
Z9 9
U1 4
U2 25
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0002-7863
J9 J AM CHEM SOC
JI J. Am. Chem. Soc.
PD JUL 2
PY 2014
VL 136
IS 26
BP 9484
EP 9490
DI 10.1021/ja504617n
PG 7
WC Chemistry, Multidisciplinary
SC Chemistry
GA AK8QI
UT WOS:000338692700036
PM 24884988
ER
PT J
AU Allison, PG
Rodriguez, RI
Moser, RD
Williams, BA
Poda, AR
Seiter, JM
Lafferty, BJ
Kennedy, AJ
Chandler, MQ
AF Allison, Paul G.
Rodriguez, Rogie I.
Moser, Robert D.
Williams, Brett A.
Poda, Aimee R.
Seiter, Jennifer M.
Lafferty, Brandon J.
Kennedy, Alan J.
Chandler, Mei Q.
TI Characterization Of Multi-layered Fish Scales (Atractosteus spatula)
Using Nanoindentation, X-ray CT, FTIR, and SEM
SO JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
LA English
DT Article
DE Bioengineering; Issue 89; Atractosteus spatula; structure-property
relation; nanoindentation; scan electron microscopy; X-ray computed
tomography; Fourier transform infrared (FTIR) spectroscopy
ID MECHANICAL-PROPERTIES; CONCRETE; DESIGN
AB The hierarchical architecture of protective biological materials such as mineralized fish scales, gastropod shells, ram's horn, antlers, and turtle shells provides unique design principles with potentials for guiding the design of protective materials and systems in the future. Understanding the structure-property relationships for these material systems at the microscale and nanoscale where failure initiates is essential. Currently, experimental techniques such as nanoindentation, X-ray CT, and SEM provide researchers with a way to correlate the mechanical behavior with hierarchical microstructures of these material systems. However, a well-defined standard procedure for specimen preparation of mineralized biomaterials is not currently available. In this study, the methods for probing spatially correlated chemical, structural, and mechanical properties of the multilayered scale of A. spatula using nanoindentation, FTIR, SEM, with energy-dispersive X-ray (EDX) microanalysis, and X-ray CT are presented.
C1 [Allison, Paul G.; Moser, Robert D.; Williams, Brett A.; Chandler, Mei Q.] US Army, Geotech & Struct Lab, Engn Res & Dev Ctr, Washington, DC 20310 USA.
[Rodriguez, Rogie I.] Univ Alabama, Dept Mech Engn, Tuscaloosa, AL 35487 USA.
[Poda, Aimee R.; Seiter, Jennifer M.; Lafferty, Brandon J.; Kennedy, Alan J.] US Army, Environm Lab, Engn Res & Dev Ctr, Washington, DC 20310 USA.
RP Allison, PG (reprint author), US Army, Geotech & Struct Lab, Engn Res & Dev Ctr, Washington, DC 20310 USA.
EM paul.g.allison@usace.army.mil
RI Poda, Aimee/K-1905-2012
FU US Army ERDC Military Engineering 6.1 Basic Research Program; ERDC
Center for Directed Research Program
FX The Authors would like to acknowledge the financial support for this
work provided by the US Army ERDC Military Engineering 6.1 Basic
Research Program and the ERDC Center for Directed Research Program. The
Authors would also like to thank the staff and facilities of the ERDC
Geotechnical and Structural Laboratory's Concrete and Materials Branch
for supporting the experimental work. Permission to publish was granted
by the Director, Geotechnical & Structures Laboratory.
NR 18
TC 1
Z9 1
U1 3
U2 11
PU JOURNAL OF VISUALIZED EXPERIMENTS
PI CAMBRIDGE
PA 1 ALEWIFE CENTER, STE 200, CAMBRIDGE, MA 02140 USA
SN 1940-087X
J9 JOVE-J VIS EXP
JI J. Vis. Exp.
PD JUL
PY 2014
IS 89
AR e51535
DI 10.3791/51535
PG 9
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA CB0DR
UT WOS:000349296100035
ER
PT J
AU Goldman, GH
AF Goldman, Geoffrey H.
TI Blind Focusing Algorithm Applied to the Acoustic Signal of a Maneuvering
Rotorcraft
SO IEEE TRANSACTIONS ON AEROSPACE AND ELECTRONIC SYSTEMS
LA English
DT Article
ID MOTION COMPENSATION; TRACKING; LOCALIZATION; AIRCRAFT; SENSOR
AB An algorithm was developed and tested to blindly focus the acoustic spectra of a rotorcraft that was blurred by time-varying Doppler shifts and other effects such atmospheric distortion. First, the fundamental frequency generated by the main rotor blades of a rotorcraft was tracked using a fixed-lag smoother. Then, the frequency estimates were used to resample the data using interpolation. Next, the motion-compensated data were further focused using a technique based upon the phase gradient autofocus (PGA) algorithm. The performance of the algorithm was evaluated by analyzing the increase in the amplitude of the harmonics due to focusing the data. For most of the data, the algorithm focused the harmonics between approximately 10-90 Hz to within 1-2 dB of an estimated upper bound (UB) obtained from conservation of energy and estimates of the Doppler shift. In addition, the algorithm was able to separate two closely spaced frequencies in the spectra of the rotorcraft. The algorithm developed can be used to preprocess data for classification, nulling, and tracking algorithms.
C1 US Army, Res Lab, Acoust & Electromagnet Sensing Branch, Adelphi, MD 20783 USA.
RP Goldman, GH (reprint author), US Army, Res Lab, Acoust & Electromagnet Sensing Branch, 2800 Powder Mill Rd, Adelphi, MD 20783 USA.
EM geoffrey.h.goldman.civ@mail.mil
NR 31
TC 0
Z9 0
U1 1
U2 2
PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
PI PISCATAWAY
PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA
SN 0018-9251
EI 1557-9603
J9 IEEE T AERO ELEC SYS
JI IEEE Trans. Aerosp. Electron. Syst.
PD JUL
PY 2014
VL 50
IS 3
BP 1715
EP 1725
DI 10.1109/TAES.2014.130321
PG 11
WC Engineering, Aerospace; Engineering, Electrical & Electronic;
Telecommunications
SC Engineering; Telecommunications
GA AX2RF
UT WOS:000346791100011
ER
PT J
AU Jensen, JO
Jensen, JL
Chue, CC
AF Jensen, James O.
Jensen, Janet L.
Chue, Calvin C.
TI Nanoengineered Bioplatforms Based on DNA Origami
SO PROCEEDINGS OF THE IEEE
LA English
DT Editorial Material
ID NANOSTRUCTURES
C1 [Jensen, James O.; Jensen, Janet L.; Chue, Calvin C.] US Army, Res & Technol Directorate, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA.
RP Jensen, JO (reprint author), US Army, Res & Technol Directorate, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA.
NR 5
TC 1
Z9 1
U1 3
U2 15
PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
PI PISCATAWAY
PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA
SN 0018-9219
EI 1558-2256
J9 P IEEE
JI Proc. IEEE
PD JUL
PY 2014
VL 102
IS 7
SI SI
BP 1046
EP 1049
DI 10.1109/JPROC.2014.2326808
PG 4
WC Engineering, Electrical & Electronic
SC Engineering
GA AK1PQ
UT WOS:000338187700001
ER
PT J
AU Checkai, R
Van Genderen, E
Sousa, JP
Stephenson, G
Smolders, E
AF Checkai, Ron
Van Genderen, Eric
Sousa, Jose Paulo
Stephenson, Gladys
Smolders, Erik
TI Deriving Site-Specific Clean-Up Criteria to Protect Ecological Receptors
(Plants and Soil Invertebrates) Exposed to Metal or Metalloid Soil
Contaminants via the Direct Contact Exposure Pathway
SO INTEGRATED ENVIRONMENTAL ASSESSMENT AND MANAGEMENT
LA English
DT Article
ID NOEC TOXICITY DATA; RISK APPROACH; MOLYBDENUM; ACCOUNT; VALUES; COPPER;
LIMITS; ZINC
AB Soil contaminant concentration limits for the protection of terrestrial plants and soil invertebrates are commonly based on thresholds derived using data from laboratory ecotoxicity tests. A comprehensive assessment has been made for the derivation of ecological soil screening levels (Eco-SSL) in the United States; however, these limits are conservative because of their focus on high bioavailability scenarios. Here, we explain and evaluate approaches to soil limit derivation taken by 4 jurisdictions, 2 of which allow for correction of data for factors affecting bioavailability among soils, and between spiked and field-contaminated soils (Registration Evaluation Authorisation and Restriction of Chemicals [REACH] Regulation, European Union [EU], and the National Environment Protection Council [NEPC], Australia). Scientifically advanced features from these methods have been integrated into a newly developed method for deriving soil clean-up values (SCVs) within the context of site-specific baseline ecological risk assessment. Resulting site-specific SCVs that account for bioavailability may permit a greater residual concentration in soil when compared to generic screening limit concentrations (e.g., Eco-SSL), while still affording acceptable protection. Two choices for selecting the level of protection are compared (i.e., allowing higher effect levels per species, or allowing a higher percentile of species that are potentially unprotected). Implementation of this new method is presented for the jurisdiction of the United States, with a focus on metal and metalloid contaminants; however, the new method can be used in any jurisdiction. A case study for molybdate shows the large effect of bioavailability corrections and smaller effects of protection level choices when deriving SCVs. (C) 2014 The Authors. Integrated Environmental Assessment and Management published by Wiley Periodicals, Inc. on behalf of SETAC.
RP Checkai, R (reprint author), US Army Edgewood Chem Biol Ctr, Environm Toxicol Branch, Aberdeen Proving Ground, MD 21010 USA.
EM Ronald.T.Checkai.Civ@mail.mil
RI Sousa, Jose Paulo/H-5407-2011
OI Sousa, Jose Paulo/0000-0001-8045-4296
NR 34
TC 6
Z9 6
U1 3
U2 11
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1551-3777
EI 1551-3793
J9 INTEGR ENVIRON ASSES
JI Integr. Environ. Assess. Manag.
PD JUL
PY 2014
VL 10
IS 3
BP 346
EP 357
DI 10.1002/ieam.1528
PG 12
WC Environmental Sciences; Toxicology
SC Environmental Sciences & Ecology; Toxicology
GA AK0VG
UT WOS:000338133500006
PM 24470189
ER
PT J
AU Kuperman, RG
Siciliano, SD
Rombke, J
Oorts, K
AF Kuperman, Roman G.
Siciliano, Steven D.
Roembke, Joerg
Oorts, Koen
TI Deriving Site-Specific Soil Clean-Up Values for Metals and Metalloids:
Rationale for Including Protection of Soil Microbial Processes
SO INTEGRATED ENVIRONMENTAL ASSESSMENT AND MANAGEMENT
LA English
DT Article
AB Although it is widely recognized that microorganisms are essential for sustaining soil fertility, structure, nutrient cycling, groundwater purification, and other soil functions, soil microbial toxicity data were excluded from the derivation of Ecological Soil Screening Levels (Eco-SSL) in the United States. Among the reasons for such exclusion were claims that microbial toxicity tests were too difficult to interpret because of the high variability of microbial responses, uncertainty regarding the relevance of the various endpoints, and functional redundancy. Since the release of the first draft of the Eco-SSL Guidance document by the US Environmental Protection Agency in 2003, soil microbial toxicity testing and its use in ecological risk assessments have substantially improved. A wide range of standardized and nonstandardized methods became available for testing chemical toxicity to microbial functions in soil. Regulatory frameworks in the European Union and Australia have successfully incorporated microbial toxicity data into the derivation of soil threshold concentrations for ecological risk assessments. This article provides the 3-part rationale for including soil microbial processes in the development of soil clean-up values (SCVs): 1) presenting a brief overview of relevant test methods for assessing microbial functions in soil, 2) examining data sets for Cu, Ni, Zn, and Mo that incorporated soil microbial toxicity data into regulatory frameworks, and 3) offering recommendations on how to integrate the best available science into the method development for deriving site-specific SCVs that account for bioavailability of metals and metalloids in soil. Although the primary focus of this article is on the development of the approach for deriving SCVs for metals and metalloids in the United States, the recommendations provided in this article may also be applicable in other jurisdictions that aim at developing ecological soil threshold values for protection of microbial processes in contaminated soils. (C) 2014 The Authors. Integrated Environmental Assessment and Management published by Wiley Periodicals, Inc. on behalf of SETAC.
RP Kuperman, RG (reprint author), US Army Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA.
EM roman.g.kuperman.civ@mail.mil
OI Kuperman, Roman/0000-0001-5344-1633; Rombke, Jorg/0000-0003-1341-634X;
Oorts, Koen/0000-0002-8328-3581
NR 46
TC 5
Z9 5
U1 1
U2 10
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1551-3777
EI 1551-3793
J9 INTEGR ENVIRON ASSES
JI Integr. Environ. Assess. Manag.
PD JUL
PY 2014
VL 10
IS 3
BP 388
EP 400
DI 10.1002/ieam.1513
PG 13
WC Environmental Sciences; Toxicology
SC Environmental Sciences & Ecology; Toxicology
GA AK0VG
UT WOS:000338133500009
PM 24376192
ER
PT J
AU Wambeke, BW
Liu, M
Hsiang, SM
AF Wambeke, Brad W.
Liu, Min
Hsiang, Simon M.
TI Task Variation and the Social Network of Construction Trades
SO JOURNAL OF MANAGEMENT IN ENGINEERING
LA English
DT Article
DE Variation; Risk assessment; Social network; Performance; Construction
ID MULTIATTRIBUTE UTILITY MEASUREMENT; PRODUCTIVITY; MANAGEMENT
AB Construction projects can be complex and managers are faced with the challenge of managing multiple trades working on a large number of interdependent tasks. When one trade or task experiences variation, defined as the time difference between what was planned and what occurred for this research, additional trades or tasks can be impacted. This can result in a disrupted project schedule and reduced productivity. A case study involving a general contractor (GC) building a $50 million, 150,000 sq ft data collection center was conducted. Both starting time and task duration variation data was collected on approximately 1,200 tasks performed by over 40 trades. A risk assessment matrix was used to determine which causes of variation posed the greatest risk to project performance. Pajek, a social network analysis software, was used to illustrate the organizational structure of the key trades throughout the project based on spatial proximity. It was found that material delivery and not having prerequisite work completed were the top two causes of starting time variation and overcommitment was the top cause of task duration variation. The study couples the variation analysis with the associated social network of trades to create a decision making system, thus, the paper's main contribution to the body of knowledge. The results of this research are repeatable and can be useful for managers in improving project performance. (C) 2014 American Society of Civil Engineers.
C1 [Wambeke, Brad W.] US Mil Acad, Dept Civil & Mech Engn, West Point, NY 10996 USA.
[Liu, Min] N Carolina State Univ, Dept Civil Construct & Environm Engn, Raleigh, NC 27695 USA.
[Hsiang, Simon M.] Texas Tech Univ, Lubbock, TX 79409 USA.
RP Liu, M (reprint author), N Carolina State Univ, Dept Civil Construct & Environm Engn, Raleigh, NC 27695 USA.
EM bwwambek@ncsu.edu; min_liu@ncsu.edu; simon.hsiang@ttu.edu
NR 26
TC 2
Z9 2
U1 3
U2 16
PU ASCE-AMER SOC CIVIL ENGINEERS
PI RESTON
PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA
SN 0742-597X
EI 1943-5479
J9 J MANAGE ENG
JI J. Manage. Eng.
PD JUL
PY 2014
VL 30
IS 4
AR 05014008
DI 10.1061/(ASCE)ME.1943-5479.0000219
PG 8
WC Engineering, Industrial; Engineering, Civil
SC Engineering
GA AW2PT
UT WOS:000346131500011
ER
PT J
AU Wright, ER
Cho, K
Hastak, M
AF Wright, Erik R.
Cho, Kyuman
Hastak, Makarand
TI Assessment of Critical Construction Engineering and Management Aspects
of Nuclear Power Projects
SO JOURNAL OF MANAGEMENT IN ENGINEERING
LA English
DT Article
DE Nuclear power construction; Exploratory factor analysis
AB Thirty years ago when the last nuclear power plant was ordered in the United States, many nuclear projects were suffering from large cost and schedule overruns, which were often caused by poor project management practices and a general lack of nuclear experience. This research aims at illustrating (1) critical project management areas and tasks with respect to a nuclear project life cycle; and (2) critical aspects associated with the successful nuclear construction projects. As a result, this research identified the relative priorities of six phases of a modified engineering procurement construction (EPC) project life cycle with respect to nuclear construction projects based on the results of descriptive statistics. Subsequently, 76 tasks embedded in the modified life cycle were condensed into 12 critical aspects of nuclear construction projects using an exploratory factor analysis method. Consequently, this research is aimed at establishing the basis for the development of a modern nuclear construction body of knowledge and the education of the future experienced cadre of nuclear construction professionals. (C) 2014 American Society of Civil Engineers.
C1 [Wright, Erik R.] US Mil Acad, Dept Civil & Mech Engn, West Point, NY 10996 USA.
[Cho, Kyuman] Chosun Univ, Sch Architecture, Kwangju 501759, South Korea.
[Hastak, Makarand] Purdue Univ, Div Construct Engn & Management, W Lafayette, IN 47907 USA.
RP Cho, K (reprint author), Chosun Univ, Sch Architecture, Kwangju 501759, South Korea.
EM erik.wright@usma.edu; cho129@chosun.ac.kr; hastak@purdue.edu
NR 16
TC 1
Z9 1
U1 3
U2 14
PU ASCE-AMER SOC CIVIL ENGINEERS
PI RESTON
PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA
SN 0742-597X
EI 1943-5479
J9 J MANAGE ENG
JI J. Manage. Eng.
PD JUL
PY 2014
VL 30
IS 4
AR 04014016
DI 10.1061/(ASCE)ME.1943-5479.0000286
PG 11
WC Engineering, Industrial; Engineering, Civil
SC Engineering
GA AW2PT
UT WOS:000346131500006
ER
PT J
AU Pilia, M
McDaniel, JS
Guda, T
Chen, XK
Rhoads, RP
Allen, RE
Corona, BT
Rathbone, CR
AF Pilia, M.
McDaniel, J. S.
Guda, T.
Chen, X. K.
Rhoads, R. P.
Allen, R. E.
Corona, B. T.
Rathbone, C. R.
TI TRANSPLANTATION AND PERFUSION OF MICROVASCULAR FRAGMENTS IN A RODENT
MODEL OF VOLUMETRIC MUSCLE LOSS INJURY
SO EUROPEAN CELLS & MATERIALS
LA English
DT Article
DE Microvessel; volumetric muscle loss; skeletal muscle; stem cell;
angiogenesis
ID HUMAN ADIPOSE-TISSUE; SKELETAL-MUSCLE; STEM-CELLS; SATELLITE CELLS;
ENDOTHELIAL-CELLS; IN-VITRO; ANGIOGENESIS; REGENERATION; THERAPY;
VASCULARIZATION
AB Few clinical options are available for the treatment of volumetric muscle loss (VML). An important consideration that needs to be addressed for the development of treatments for these injuries is the establishment of a vascular supply sufficient to support skeletal muscle regeneration. The objective of the current study was to evaluate the potential for microvascular fragments (MVFs) harvested from adipose tissue to support tissue perfusion for VML. Tibialis anterior muscle defects in rats were replaced with constructs that were created on the day of surgery containing either (1) collagen only (COL), (2) freshly isolated microvascular fragments in collagen (MVF), or (3) adipose tissue derived stem cells (ASCs) in collagen. Muscles were harvested 7 and 14 days after surgery. Defects treated with MVFs had a vessel density higher than the other groups at both 7 and 14 days, and those treated with ASCs had a higher vessel density than COL by day 14 (p < 0.05). Perfused vessels were observed in both the ASC and MVF treated defects at day 14, as well as at day 7 in the MVF. This study supports the use of MVFs as a platform to improve tissue perfusion to treat large VML defects. The use of freshly isolated MVFs on the day of surgery supports their clinical use and application.
C1 [Pilia, M.; McDaniel, J. S.; Guda, T.; Chen, X. K.; Corona, B. T.; Rathbone, C. R.] US Army, Inst Surg Res, Ft Sam Houston, TX 78234 USA.
[Guda, T.] Univ Texas San Antonio, Dept Biomed Engn, San Antonio, TX USA.
[Rhoads, R. P.] Virginia Tech, Dept Anim & Poultry Sci, Blacksburg, VA USA.
[Rhoads, R. P.; Allen, R. E.] Univ Arizona, Dept Anim Sci, Tucson, AZ 85721 USA.
RP Rathbone, CR (reprint author), 3698 Chambers Pass BLDG 3611 JBSA, Ft Sam Houston, TX 78234 USA.
EM christopher.r.rathbone.civ@mail.mil
RI Rhoads, Robert/F-2861-2016
OI Rhoads, Robert/0000-0002-5205-5834
FU U.S. Army Medical Research and Materiel Command of the Department of
Defense
FX This study was supported by the U.S. Army Medical Research and Materiel
Command of the Department of Defense. The opinions or assertions
contained herein are the private views of the authors and are not to be
construed as official or reflecting the views of the Department of
Defense or US government. This research was performed while the author
(M. P) held a National Research Council Research Associateship Award at
the United States Army Institute of Surgical Research. The authors would
like to express their sincere gratitude to Monica Jalomo, Janet Roe, and
Stephanie Roth for their invaluable technical assistance.
NR 38
TC 13
Z9 13
U1 0
U2 3
PU AO RESEARCH INSTITUTE DAVOS-ARI
PI DAVOS
PA CLAVADELERSTRASSE 8, DAVOS, CH 7270, SWITZERLAND
SN 1473-2262
J9 EUR CELLS MATER
JI Eur. Cells Mater.
PD JUL-DEC
PY 2014
VL 28
BP 11
EP 24
PG 14
WC Cell & Tissue Engineering; Engineering, Biomedical; Materials Science,
Biomaterials
SC Cell Biology; Engineering; Materials Science
GA AU4EQ
UT WOS:000345562600002
PM 25017641
ER
PT J
AU Paullin, C
Legree, PJ
Sinclair, AL
Moriarty, KO
Campbell, RC
Kilcullen, RN
AF Paullin, Cheryl
Legree, Peter J.
Sinclair, Andrea L.
Moriarty, Karen O.
Campbell, Roy C.
Kilcullen, Robert N.
TI Delineating Officer Performance and Its Determinants
SO MILITARY PSYCHOLOGY
LA English
DT Article
DE job analysis; job duties; Army officer; leader performance; leader tasks
ID VOLUNTARY TURNOVER; JOB EMBEDDEDNESS; LEADERSHIP
AB The U.S. Army faces complex challenges in building and sustaining its officer force. It needs to identify and develop individuals who can adapt to many different mission types and to the various environments in which the Army operates, develop the strategic and tactical leadership skills necessary to perform effectively in higher ranks, and embrace the Army's warrior ethos. To create a performance-based foundation for accessing, assigning, training, and retaining officers, we conducted a job analysis study. Using Army doctrine, protocol, training manuals, and input from a number of Army officers, we identified 46 leader and management major duties that officers must perform with a high level of competence. The list is intended to be relevant for all Army officer positions and levels up to lieutenant colonel, though the relative importance of and time spent on specific duties varies by level, position, branch, and mission. We also identified 55 stable individual difference attributes and attitudes that underlie the determinants of officer performance and retention. We framed our study according to 2 models of job performance, 1 specifying the determinants of job performance and the other specifying the major components of job performance. The integrated models provide a theoretical basis for designing personnel systems or interventions to impact specific components of officer performance and for predicting their likely outcomes.
C1 [Paullin, Cheryl; Sinclair, Andrea L.; Moriarty, Karen O.; Campbell, Roy C.] Human Resources Res Org, Alexandria, VA USA.
[Legree, Peter J.; Kilcullen, Robert N.] US Army Res Inst Behav & Social Sci, Ft Belvoir, VA USA.
RP Paullin, C (reprint author), HumRRO, 100 Washington Ave S,Suite 1660, Minneapolis, MN 55401 USA.
EM cpaullin@humrro.org
NR 74
TC 2
Z9 2
U1 1
U2 5
PU AMER PSYCHOLOGICAL ASSOC
PI WASHINGTON
PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA
SN 0899-5605
EI 1532-7876
J9 MIL PSYCHOL
JI Milit. Psychol.
PD JUL
PY 2014
VL 26
IS 4
SI SI
BP 259
EP 277
DI 10.1037/mil0000051
PG 19
WC Psychology, Multidisciplinary
SC Psychology
GA AU2MR
UT WOS:000345453100002
ER
PT J
AU Wolters, HMK
O'Shea, PG
Ford, LA
Fleisher, MS
Adeniyi, MA
Conzelman, CE
Webster, RJ
AF Wolters, Heather M. K.
O'Shea, Patrick Gavan
Ford, Laura A.
Fleisher, Matthew S.
Adeniyi, Mary A.
Conzelman, Clair E.
Webster, Russell J.
TI Identifying and Training Brigade Command Competencies
SO MILITARY PSYCHOLOGY
LA English
DT Article
DE brigade command; competency modeling; training competency clusters;
leadership; training methods
ID LEADERSHIP
AB This research identified competencies required to command a brigade. Interviews and surveys of military personnel provided a multisource perspective of brigade command competencies, including the proficiency level needed for each competency. Thirty-nine competencies were identified and categorized into 4 training-oriented clusters: leadership skills, operational skills, personal capabilities, and knowledge base. Participants reported their preferred methods to develop the competencies within each cluster. The competencies can be used to assess training effectiveness and to identify potential training gaps. Additionally, the model has utility outside of the military, as it describes a framework for leaders who must bridge the gap between organizational and strategic leadership.
C1 [Wolters, Heather M. K.] US Army Res Inst Behav & Social Sci, Ft Belvoir, VA USA.
[O'Shea, Patrick Gavan; Ford, Laura A.; Fleisher, Matthew S.; Adeniyi, Mary A.; Conzelman, Clair E.] Human Resources Res Org, Louisville, KY USA.
[Webster, Russell J.] Consortium Res Fellows Program, Alexandria, VA USA.
RP Wolters, HMK (reprint author), US Army Res Inst, 6000 6th St, Ft Belvoir, VA 22060 USA.
EM heather.wolters@us.army.mil
NR 26
TC 3
Z9 3
U1 1
U2 9
PU AMER PSYCHOLOGICAL ASSOC
PI WASHINGTON
PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA
SN 0899-5605
EI 1532-7876
J9 MIL PSYCHOL
JI Milit. Psychol.
PD JUL
PY 2014
VL 26
IS 4
SI SI
BP 278
EP 291
DI 10.1037/mil0000052
PG 14
WC Psychology, Multidisciplinary
SC Psychology
GA AU2MR
UT WOS:000345453100003
ER
PT J
AU Legree, PJ
Kilcullen, RN
Putka, DJ
Wasko, LE
AF Legree, Peter J.
Kilcullen, Robert N.
Putka, Dan J.
Wasko, Laurie E.
TI Identifying the Leaders of Tomorrow: Validating Predictors of Leader
Performance
SO MILITARY PSYCHOLOGY
LA English
DT Article
DE ROTC; CBEF; TAPAS; leader potential
AB The Reserve Officers' Training Corps (ROTC) is the largest commissioning source for the U.S. Army. Although some ROTC cadets receive no scholarship assistance, other cadets receive 2-, 3-, or 4-year ROTC scholarships in exchange for incurring a military service obligation after college graduation. The Army is particularly interested in awarding 4-year scholarships to individuals who are likely to excel in ROTC and become Army leaders. This research examined how well measures of temperament, work values, and leadership knowledge predicted the performance 4-year scholarship winners in various phases of ROTC, including their ranking on a national Order of Merit Listing in their senior year of college. Measures of temperament, work values, and leader knowledge strongly predicted each of the ROTC performance metrics.
C1 [Legree, Peter J.; Kilcullen, Robert N.] US Army Res Inst Behav & Social Sci, Ft Belvoir, VA 22026 USA.
[Putka, Dan J.; Wasko, Laurie E.] Human Resources Res Org, Alexandria, VA USA.
RP Legree, PJ (reprint author), US Army Res Inst Behav & Social Sci, 6000 6th St,Bldg 1464 Mail Stop 5610, Ft Belvoir, VA 22026 USA.
EM peter.j.legree.civ@mail.mil
NR 20
TC 4
Z9 4
U1 3
U2 5
PU AMER PSYCHOLOGICAL ASSOC
PI WASHINGTON
PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA
SN 0899-5605
EI 1532-7876
J9 MIL PSYCHOL
JI Milit. Psychol.
PD JUL
PY 2014
VL 26
IS 4
SI SI
BP 292
EP 309
DI 10.1037/mil0000054
PG 18
WC Psychology, Multidisciplinary
SC Psychology
GA AU2MR
UT WOS:000345453100004
ER
PT J
AU Allen, MT
Bynum, BH
Oliver, JT
Russell, TL
Young, MC
Babin, NE
AF Allen, Matthew T.
Bynum, Bethany H.
Oliver, Joy T.
Russell, Teresa L.
Young, Mark C.
Babin, Nehama E.
TI Predicting Leadership Performance and Potential in the US Army Officer
Candidate School (OCS)
SO MILITARY PSYCHOLOGY
LA English
DT Article
DE Officer Candidate School; leadership; implicit leadership; general
cognitive ability; personality
ID ORGANIZATIONAL COMMITMENT; MISSING DATA; CONSTRUCT-VALIDITY;
PERSONALITY; ANTECEDENTS; CONSEQUENCES; METAANALYSIS; MOTIVATION;
KNOWLEDGE; SETTINGS
AB The purpose of this article was to determine proximal and distal antecedents of leadership in the U.S. Army's Officer Candidate School (OCS). A model composed of motivation to lead, leadership self-efficacy, implicit leadership, organizational commitment, general cognitive ability, and personality was proposed. Results from a longitudinal examination of 1,232 officer candidates suggest partial support for the model, and limited evidence for enlisted experience as a moderator. Candidate personality (partially mediated by interest in leadership and leadership self-efficacy) best predicted leadership performance during OCS and peer ratings of leadership potential. Implications for OCS selection and models of leadership performance are discussed.
C1 [Allen, Matthew T.; Bynum, Bethany H.; Oliver, Joy T.; Russell, Teresa L.] Human Resources Res Org, Alexandria, VA USA.
[Young, Mark C.; Babin, Nehama E.] US Army Res Inst Behav & Social Sci, Ft Belvoir, VA USA.
RP Allen, MT (reprint author), Dept Def, ATTN MTD3 Suite 6665,9800 Savage Rd, Ft George G Meade, MD 20755 USA.
EM matt.allen250@gmail.com
NR 57
TC 2
Z9 2
U1 5
U2 15
PU AMER PSYCHOLOGICAL ASSOC
PI WASHINGTON
PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA
SN 0899-5605
EI 1532-7876
J9 MIL PSYCHOL
JI Milit. Psychol.
PD JUL
PY 2014
VL 26
IS 4
SI SI
BP 310
EP 326
DI 10.1037/mil0000056
PG 17
WC Psychology, Multidisciplinary
SC Psychology
GA AU2MR
UT WOS:000345453100005
ER
PT J
AU Kelly, DR
Matthews, MD
Bartone, PT
AF Kelly, Dennis R.
Matthews, Michael D.
Bartone, Paul T.
TI Grit and Hardiness as Predictors of Performance Among West Point Cadets
SO MILITARY PSYCHOLOGY
LA English
DT Article
DE grit; hardiness; leadership; noncognitive
ID ACADEMY
AB The U.S. Military Academy has historically used an academically weighted composite of aptitude, leadership, and physical ability indices for selection of candidates and to predict their performance at the Academy. Researchers at West Point have begun to investigate the incremental contribution of a variety of less traditional nonaptitude or noncognitive factors in predicting performance. Particular focus has centered on hardiness and grit because they have been shown to predict persistence through Cadet Basic Training (CBT) and achievement in the first year at the Academy. In the current investigation, we further examined the predictive validity of grit and hardiness, and their subfacets, on retention and performance through the full 4-year West Point program with data from 1,558 cadets, comprising the West Point classes of 2009 and 2010. Results of regression analyses indicate that whereas grit interest and hardiness commitment were the sole predictors of attrition from CBT, only grit effort predicted persistence across the remaining 4 year period. College Entrance Exam Rank (CEER), a traditional measure of academic success, did not predict persistence. In terms of performance, grit interest, and hardiness control added to CEER in the prediction of 4-year academic performance. Although CEER continued to be the best predictor of military performance, grit effort and hardiness commitment were also important contributors. Finally, grit effort also added to the Athletic Activities Score and CEER in predicting physical performance. These results indicate that the noncognitive factors grit and hardiness are important predictors of success in military officer candidates. We discuss the implication of our findings for selection and prediction of performance of within military environments.
C1 [Kelly, Dennis R.; Matthews, Michael D.] US Mil Acad, West Point, NY 10996 USA.
[Bartone, Paul T.] Natl Def Univ, Ctr Technol & Natl Secur Policy, Washington, DC 20319 USA.
RP Kelly, DR (reprint author), US Mil Acad, Taylor Hall,5th Floor, West Point, NY 10996 USA.
EM dennis.kelly@usma.edu
OI Bartone, Paul/0000-0002-5767-0086
NR 27
TC 8
Z9 8
U1 5
U2 28
PU AMER PSYCHOLOGICAL ASSOC
PI WASHINGTON
PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA
SN 0899-5605
EI 1532-7876
J9 MIL PSYCHOL
JI Milit. Psychol.
PD JUL
PY 2014
VL 26
IS 4
SI SI
BP 327
EP 342
DI 10.1037/mil0000050
PG 16
WC Psychology, Multidisciplinary
SC Psychology
GA AU2MR
UT WOS:000345453100006
ER
PT J
AU Bousman, WG
AF Bousman, William G.
TI Rotorcraft Airloads Measurements: Extraordinary Costs, Extraordinary
Benefits The 31st Alexander Nikolsky Honorary Lecture
SO JOURNAL OF THE AMERICAN HELICOPTER SOCIETY
LA English
DT Article
ID PREDICTION; FLIGHT; PRESSURE; ROTORS; UH-60A; CFD
AB The first airloads measurements were made in the 1950s at NACA Langley on a 15.3-ft-diameter model rotor, stimulated by the invention of miniaturized pressure transducers. The inability to predict higher harmonic loads in those early years led the U.S. Army to fund airloads measurements on the CH-34 and the UH-1A aircraft. Nine additional comprehensive airloads tests have been done since that early work, including the recent test of an instrumented UH-60A rotor in the 40- x 80-ft Wind Tunnel at NASA Ames. This historical narrative discusses the 12 airloads tests and how the results were integrated with analytical efforts. The recent history of the UH-60A Airloads Workshops is presented, and it is shown that new developments in analytical methods have transformed our capability to predict airloads that are critical for design.
C1 [Bousman, William G.] US Army Aeroflightdynam Directorate, Moffett Field, CA USA.
EM barlowi@earthlink.net
NR 125
TC 1
Z9 1
U1 0
U2 6
PU AMER HELICOPTER SOC INC
PI ALEXANDRIA
PA 217 N WASHINGTON ST, ALEXANDRIA, VA 22314 USA
SN 0002-8711
EI 2161-6027
J9 J AM HELICOPTER SOC
JI J. Am. Helicopter Soc.
PD JUL
PY 2014
VL 59
IS 3
AR 031001
DI 10.4050/JAHS.59.031001
PG 30
WC Engineering, Aerospace
SC Engineering
GA AS6HX
UT WOS:000344365900001
ER
PT J
AU Smith, TJ
White, A
Hadden, L
Young, AJ
Marriott, BP
AF Smith, Tracey J.
White, Alan
Hadden, Louise
Young, Andrew J.
Marriott, Bernadette P.
TI Associations between Mental Health Disorders and Body Mass Index among
Military Personnel
SO AMERICAN JOURNAL OF HEALTH BEHAVIOR
LA English
DT Article
DE BMI; mental health
ID POSTTRAUMATIC-STRESS-DISORDER; NUTRITION EXAMINATION SURVEY;
SELF-REPORTED HEIGHT; 3RD NATIONAL-HEALTH; GENERAL-POPULATION;
PSYCHOLOGICAL DISTRESS; US ADULTS; OBESITY; DEPRESSION; SUICIDE
AB Objective: To determine if overweight or obesity is associated with mental health disorder (MHD) symptoms among military personnel Methods: Secondary analysis using the 2005 Department of Defense Health Related Behaviors Survey (N = 15,195). Standard Body Mass Index (BMI) categories were used to classify participants' body composition. Results: For women, obesity was associated with symptoms of serious psychological distress (SPD), post-traumatic stress disorder, and depression. For men, obesity and overweight was associated with symptoms of generalized anxiety disorder and SPD, respectively. Self-reported high personal stress was the strongest predictor of MHD symptoms and suicide attempts. Conclusion: Self-reported stress was a stronger predictor of MHD symptoms than BMI. There is potential value in screening personnel for personal stress as a MHD risk factor.
C1 [Smith, Tracey J.; Young, Andrew J.] US Army Res Inst Environm Med, Mil Nutr Div, Natick, MA 01760 USA.
[White, Alan] Abt Associates Inc, Durham, NC USA.
[Hadden, Louise] Abt Associates Inc, Cambridge, MA USA.
[Marriott, Bernadette P.] Med Univ S Carolina, Dept Med, Div Gastroenterol, Charleston, SC 29425 USA.
RP Smith, TJ (reprint author), US Army Res Inst Environm Med, Mil Nutr Div, Natick, MA 01760 USA.
EM tracey.smith10.civ@mail.mil
NR 50
TC 5
Z9 5
U1 4
U2 11
PU PNG PUBLICATIONS
PI OAK RIDGE
PA 2205-K OAK RIDGE RD, #115, OAK RIDGE, NC 27310 USA
SN 1945-7359
J9 AM J HEALTH BEHAV
JI Am. J. Health Behav.
PD JUL
PY 2014
VL 38
IS 4
BP 529
EP 540
DI 10.5993/AJHB.38.4.6
PG 12
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA AS1JC
UT WOS:000344036400006
PM 24636115
ER
PT J
AU Austin, KG
Travis, J
Pace, G
Lieberman, HR
AF Austin, Krista G.
Travis, John
Pace, Gerry
Lieberman, Harris R.
TI Analysis of 1,3 dimethylamylamine concentrations in Geraniaceae,
geranium oil and dietary supplements
SO DRUG TESTING AND ANALYSIS
LA English
DT Article
DE DMAA; pelargonium; stimulant; synthetic; DSHEA; ephedra
ID BLOOD-PRESSURE; BITTER ORANGE; HEART-RATE; PELARGONIUM;
1,3-DIMETHYLAMYLAMINE; EXTRACTS; CAFFEINE; HEALTHY; WEIGHT; SAFETY
AB 1,3-Dimethylamylamine (DMAA) is a sympathomimetic compound currently incorporated into some dietary supplements. Significant controversy exists regarding the 'natural' origin of DMAA, as claimed by manufacturers of supplements. Manufacturers often refer to its presence by the name Geranamine (R) implying that DMAA is found in the plant species Geranium and Pelargonium known collectively as Geraniaceae. This study determined whether DMAA is present in the plant species, Geranium and Pelargonium. In addition, concentrations of DMAA in popular dietary supplements and commercial Geranium and Pelargonium oils were assessed. One Pelargonium cultivar, one Geranium cultivar, three essential oils from Pelargonium or Geranium, raw DMAA powder, and seven dietary supplements (DS) sold as finished products and labelled as containing DMAA, or one of its synonyms, were analyzed for the presence of DMAA by ultra performance liquid chromatography tandemmass spectrometry (UPLC-MS/MS). No measurable levels of DMAA in Geranium, Pelargonium or essential oils at a detection limit of 1-2 ng/g were present. UPLC/MS/MS analysis confirmed the presence of DMAA in spiked plant and oil samples, all seven DS products, and raw DMAA powder. Concentrations (weight%) of DMAA provided in DS ranged from 0.11% to 673%. This study indicates DMAA contained in DS is of a synthetic origin and is not present in the plant species Geranium and Pelargonium; thus the 'natural' origin and use of DMAA as an ingredient in DS is not substantiated. Copyright (C) 2013 John Wiley & Sons, Ltd.
C1 [Austin, Krista G.; Lieberman, Harris R.] US Army, Environm Med Res Inst, Natick, MA 01760 USA.
[Austin, Krista G.] Oak Ridge Inst Sci & Educ, Belcamp, MD 21017 USA.
[Travis, John; Pace, Gerry] NSF Int, Ann Arbor, MI 48105 USA.
RP Austin, KG (reprint author), US Army, Mil Nutr Div, Environm Med Res Inst, Natick, MA 01760 USA.
EM krista.g.austin.ctr@mail.mil
FU US Army Medical Research and Materiel Command (USAMRMC); Department of
Defense Center Alliance for Dietary Supplement Research
FX This work was supported by the US Army Medical Research and Materiel
Command (USAMRMC) and the Department of Defense Center Alliance for
Dietary Supplement Research. The opinions contained herein are the
private views of the author and are not to be construed as official or
as reflecting the views of the Army or the Department of Defense.
Citations of commercial organizations and trade names in this report do
not constitute an official Department of the Army endorsement or
approval of the products or services of these organizations. Approved
for public release; distribution is unlimited.
NR 30
TC 11
Z9 11
U1 4
U2 14
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1942-7603
EI 1942-7611
J9 DRUG TEST ANAL
JI Drug Test. Anal.
PD JUL-AUG
PY 2014
VL 6
IS 7-8
SI SI
BP 797
EP 804
DI 10.1002/dta.1491
PG 8
WC Biochemical Research Methods; Chemistry, Analytical; Pharmacology &
Pharmacy
SC Biochemistry & Molecular Biology; Chemistry; Pharmacology & Pharmacy
GA AQ6YR
UT WOS:000342960300022
PM 23704033
ER
PT J
AU Urben, HA
AF Urben, Heidi A.
TI Wearing Politics on Their Sleeves? Levels of Political Activism of
Active Duty Army Officers
SO ARMED FORCES & SOCIETY
LA English
DT Article
ID MILITARY
C1 US Mil Acad, Dept Social Sci, West Point, NY 10996 USA.
RP Urben, HA (reprint author), US Mil Acad, Dept Social Sci, 607 Cullum Rd, West Point, NY 10996 USA.
EM Heidi.urben@usma.edu
NR 34
TC 2
Z9 2
U1 0
U2 2
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0095-327X
EI 1556-0848
J9 ARMED FORCES SOC
JI Armed Forces Soc.
PD JUL
PY 2014
VL 40
IS 3
BP 568
EP 591
DI 10.1177/0095327X12467774
PG 24
WC Political Science; Sociology
SC Government & Law; Sociology
GA AQ4TN
UT WOS:000342792700009
ER
PT J
AU Dempsey, J
AF Dempsey, Jason
TI Bleeding Talent How the US Military Mismanages Great Leaders and Why
It's Time for a Revolution
SO ARMED FORCES & SOCIETY
LA English
DT Book Review
C1 [Dempsey, Jason] US Army, Washington, DC 20301 USA.
RP Dempsey, J (reprint author), US Army, Washington, DC 20301 USA.
NR 5
TC 0
Z9 0
U1 0
U2 1
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0095-327X
EI 1556-0848
J9 ARMED FORCES SOC
JI Armed Forces Soc.
PD JUL
PY 2014
VL 40
IS 3
BP 592
EP 595
PG 4
WC Political Science; Sociology
SC Government & Law; Sociology
GA AQ4TN
UT WOS:000342792700010
ER
PT J
AU Chen, YJ
Lee, J
Puryear, M
Wong, RKH
Lake, JM
Maydonovitch, CL
Belle, L
Moawad, FJ
AF Chen, Yen-Ju
Lee, Jennifer
Puryear, Magaly
Wong, Roy K. H.
Lake, Jason M.
Maydonovitch, Corrine L.
Belle, Lavern
Moawad, Fouad J.
TI A Randomized Controlled Study Comparing Room Air With Carbon Dioxide for
Abdominal Pain, Distention, and Recovery Time in Patients Undergoing
Colonoscopy
SO GASTROENTEROLOGY NURSING
LA English
DT Article
ID CONTROLLED-TRIAL; CO2 INSUFFLATION; SEDATED PATIENTS
AB Colonoscopy remains the gold standard for colorectal cancer screening. Many barriers to the procedure exist including the possibility of abdominal discomfort that may occur with insufflation. Carbon dioxide (CO 2), which is rapidly absorbed in the blood stream, is an alternate method used to distend the lumen during colonoscopy. The goal of this study was to compare patient discomfort, abdominal girth, and recovery time in 2 groups of patients randomized to CO2 versus room air insufflation during colonoscopy. Using a Wong-Baker score, we found statistical difference in postprocedural discomfort levels (CO2 Group: 1.15 +/- 2.0 vs. room air: 0.41 +/- 0.31, p = .015) and a significantly greater increase in abdominal girth over CO2 immediately postprocedure (room air: 1.06 +/- 1.29 inches vs. CO2: 0.56 +/- 0.73 inches, p = .054) girth immediately postprocedure; however, recovery time was similar between the 2 study arms (CO2 : 9.1 +/- 16.2 minutes vs. room air: 10.2 +/- 18.6 minutes, p = .713). Further studies are needed to determine whether CO2 is cost-effective and improves patient satisfaction with colonoscopy.
C1 [Chen, Yen-Ju; Lee, Jennifer; Wong, Roy K. H.; Lake, Jason M.; Maydonovitch, Corrine L.; Belle, Lavern] Walter Reed Natl Mil Med Ctr, Gastroenterol Serv, Dept Med, Bethesda, MD 20889 USA.
[Puryear, Magaly] Ft Belvoir Community Hosp, Gastroenterol Serv, Dept Med, Ft Belvoir, VA USA.
[Wong, Roy K. H.; Moawad, Fouad J.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA.
[Moawad, Fouad J.] US Army, Med Corps, Bethesda, MD USA.
[Moawad, Fouad J.] Walter Reed Natl Mil Med Ctr, Motil & Reflux Testing Lab, Bethesda, MD 20889 USA.
RP Chen, YJ (reprint author), Walter Reed Natl Mil Med Ctr, Manometry & Reflux Testing Lab, Gastroenterol Clin, 8901 Wisconsin Ave,Bldg 9, Bethesda, MD 20889 USA.
EM yen-ju.chen@health.mil
NR 12
TC 1
Z9 1
U1 1
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1042-895X
EI 1538-9766
J9 GASTROENTEROL NURS
JI Gastroenterol. Nurs.
PD JUL-AUG
PY 2014
VL 37
IS 4
BP 273
EP 278
DI 10.1097/SGA.0000000000000054
PG 6
WC Gastroenterology & Hepatology; Nursing
SC Gastroenterology & Hepatology; Nursing
GA AP5BR
UT WOS:000342095200003
PM 25078041
ER
PT J
AU Sanchez, AM
Rountree, W
Berrong, M
Garcia, A
Schuetz, A
Cox, J
Frahm, N
Manak, M
Sarzotti-Kelsoe, M
D'Souza, MP
Denny, T
Ferrari, G
AF Sanchez, Ana M.
Rountree, Wes
Berrong, Mark
Garcia, Ambrosia
Schuetz, Alexandra
Cox, Josephine
Frahm, Nicole
Manak, Mark
Sarzotti-Kelsoe, Marcella
D'Souza, M. Patricia
Denny, Thomas
Ferrari, Guido
TI The External Quality Assurance Oversight Laboratory (EQAPOL) proficiency
program for IFN-gamma enzyme-linked immunospot (IFN-gamma ELISpot) assay
SO JOURNAL OF IMMUNOLOGICAL METHODS
LA English
DT Review
DE ELISpot; Standardization; Proficiency testing
ID T-CELL RESPONSES; PEPTIDE VACCINE; PHASE-II; TRIALS; CANCER; HIV;
INFECTIONS; GUIDELINES; CARCINOMA; PROTEIN
AB The interferon-gamma enzyme-linked immunospot (IFN-gamma ELISpot) assay has been developed and used as an end-point assay in clinical trials for infectious diseases and cancer to detect the magnitude of antigen-specific immune responses. The ability to compare data generated by different laboratories across organizations is pivotal to understand the relative potency of different therapeutic and vaccine strategies. We developed an external proficiency program for the IFN-gamma ELISpot assay that evaluates laboratory performance based on five parameters: timeliness for data reporting; ability to handle cellular samples; detection of background (non-specific) responses; accuracy to consensus of the results; and precision of the measurements. Points are awarded for each criterion, and the sum of the points is used to determine a numeric and adjectival performance rating. Importantly, the evaluation of the accuracy to the consensus mean for the detection of antigen-specific responses using laboratory-specific procedures informs each laboratory and its sponsor on the degree of concordance of its results with those obtained by other laboratories. This study will ultimately provide the scientific community with information on how to organize and implement an external proficiency program to evaluate longitudinally the performance of the participating laboratories and, therefore, fulfill the requirements of the GCLP guidelines for laboratories performing end-point IFN-gamma ELISpot assay for clinical trials. (C) 2014 Elsevier B.V. All rights reserved.
C1 [Sanchez, Ana M.; Rountree, Wes; Garcia, Ambrosia; Sarzotti-Kelsoe, Marcella; Denny, Thomas; Ferrari, Guido] Duke Univ, Med Ctr, Duke Human Vaccine Inst, Durham, NC 27710 USA.
[Berrong, Mark; Sarzotti-Kelsoe, Marcella; Ferrari, Guido] Duke Univ, Med Ctr, Dept Surg, Durham, NC 27710 USA.
[Schuetz, Alexandra] USAMC AFRIMS, Dept Retrovirol, Bangkok, Thailand.
[Cox, Josephine] Int AIDS Vaccine Initiat, New York, NY USA.
[Frahm, Nicole] Fred Hutchinson Canc Res Ctr, Seattle, WA 98104 USA.
[Manak, Mark] Walter Reed Army Inst Res, Dept Diagnost & Monitoring, US Mil HIV Res Program MHRP, HJF, Silver Spring, MD USA.
[Sarzotti-Kelsoe, Marcella] Duke Univ, Med Ctr, Dept Immunol, Durham, NC 27710 USA.
[Sarzotti-Kelsoe, Marcella; Ferrari, Guido] Duke Univ, Med Ctr, Duke Ctr AIDS Res, Durham, NC 27710 USA.
[D'Souza, M. Patricia] NIAID, Vaccine Clin Res Branch, Div Aids, Bethesda, MD 20892 USA.
[Denny, Thomas] Duke Univ, Med Ctr, Dept Med, Durham, NC 27710 USA.
[Denny, Thomas; Ferrari, Guido] Duke Univ, Med Ctr, Duke Global Hlth Inst, Durham, NC 27710 USA.
RP Ferrari, G (reprint author), Duke Univ, Med Ctr, Dept Surg, POB 2926, Durham, NC 27710 USA.
EM gflmp@duke.edu
RI Ferrari, Guido/A-6088-2015
FU Division of AIDS, National Institute of Allergy and Infectious Diseases,
National Institutes of Health, Department of Health and Human Services
[HHSN272201000045C]
FX This project was funded in whole, or in part, by the Division of AIDS,
National Institute of Allergy and Infectious Diseases, National
Institutes of Health, Department of Health and Human Services, under
contract no. HHSN272201000045C entitled "External Quality Assurance
Program Oversight Laboratory (EQAPOL)".
NR 30
TC 6
Z9 7
U1 0
U2 6
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0022-1759
EI 1872-7905
J9 J IMMUNOL METHODS
JI J. Immunol. Methods
PD JUL
PY 2014
VL 409
SI SI
BP 31
EP 43
DI 10.1016/j.jim.2014.03.017
PG 13
WC Biochemical Research Methods; Immunology
SC Biochemistry & Molecular Biology; Immunology
GA AO7QW
UT WOS:000341548700005
PM 24685833
ER
PT J
AU Sambor, A
Garcia, A
Berrong, M
Pickeral, J
Brown, S
Rountree, W
Sanchez, A
Pollara, J
Frahm, N
Keinonen, S
Kijak, GH
Roederer, M
Levine, G
D'Souza, MP
Jaimes, M
Koup, R
Denny, T
Cox, J
Ferrari, G
AF Sambor, Anna
Garcia, Ambrosia
Berrong, Mark
Pickeral, Joy
Brown, Sara
Rountree, Wes
Sanchez, Ana
Pollara, Justin
Frahm, Nicole
Keinonen, Sarah
Kijak, Gustavo H.
Roederer, Mario
Levine, Gail
D'Souza, M. Patricia
Jaimes, Maria
Koup, Richard
Denny, Thomas
Cox, Josephine
Ferrari, Guido
TI Establishment and maintenance of a PBMC repository for functional
cellular studies in support of clinical vaccine trials
SO JOURNAL OF IMMUNOLOGICAL METHODS
LA English
DT Review
DE Peripheral blood mononuclear cells; Cryopreservation; Repository
ID BLOOD MONONUCLEAR-CELLS; POLYCHROMATIC FLOW-CYTOMETRY;
ANTIBODY-RESPONSES; ELISPOT ASSAYS; OPTIMIZATION; HIV-1; INFECTION;
IMMUNITY; DESIGN; PANEL
AB A large repository of cryopreserved peripheral blood mononuclear cells (PBMCs) samples was created to provide laboratories testing the specimens from human immunodeficiency virus-1 (HIV-1) vaccine clinical trials the material for assay development, optimization, and validation. One hundred thirty-one PBMC samples were collected using leukapheresis procedure between 2007 and 2013 by the Comprehensive T cell Vaccine Immune Monitoring Consortium core repository. The donors included 83 human immunodeficiency virus-1 (HIV-1) seronegative and 32 HIV-1 seropositive subjects. The samples were extensively characterized for the ability of T cell subsets to respond to recall viral antigens including cytomegalovirus, Epstein-Barr virus, influenza virus, and HIV-1 using Interferon-gamma (IFN-gamma) enzyme linked immunospot (ELISpot) and IFN-gamma/interleukin 2 (IL-2) intracellular cytokine staining (ICS) assays. A subset of samples was evaluated over time to determine the integrity of the cryopreserved samples in relation to recovery, viability, and functionality. The principal results of our study demonstrate that viable and functional cells were consistently recovered from the cryopreserved samples. Therefore, we determined that this repository of large size cryopreserved cellular samples constitutes a unique resource for laboratories that are involved in optimization and validation of assays to evaluate T, B, and NI( cellular functions in the context of clinical trials. (C) 2014 Elsevier B.V. All rights reserved.
C1 [Sambor, Anna; Levine, Gail] Fdn Natl Inst Hlth, Bethesda, MD USA.
[Garcia, Ambrosia; Brown, Sara; Rountree, Wes; Sanchez, Ana; Keinonen, Sarah; Denny, Thomas; Ferrari, Guido] Duke Univ, Duke Human Vaccine Inst, Durham, NC 27710 USA.
[Garcia, Ambrosia; Berrong, Mark; Pickeral, Joy; Rountree, Wes; Sanchez, Ana; Pollara, Justin; Keinonen, Sarah; Denny, Thomas; Ferrari, Guido] Duke Univ, Med Ctr, Durham, NC 27710 USA.
[Frahm, Nicole] Fred Hutchinson Canc Res Ctr, Seattle, WA 98104 USA.
[Kijak, Gustavo H.] Walter Reed Army Inst Res, Viral Genet Sect, US Mil HIV Res Program, Henry M Jackson Fdn Adv Mil Med, Silver Spring, MD USA.
[Roederer, Mario; Koup, Richard] NIAID, Vaccine Res Ctr, NIH, Bethesda, MD 20892 USA.
[D'Souza, M. Patricia] NIAD, Div Aids, NIH, Rockville, MD USA.
[Jaimes, Maria] Becton Dickinson, San Jose, CA USA.
[Cox, Josephine] Int AIDS Vaccine Initiat, New York, NY USA.
RP Ferrari, G (reprint author), Duke Univ, Med Ctr, Dept Surg, POB 2926, Durham, NC 27710 USA.
EM gflmp@duke.edu
RI Ferrari, Guido/A-6088-2015
FU Bill & Melinda Gates Foundation [OPP1032325]
FX This work was supported by a Collaboration for AIDS Vaccine Discovery
(CAVD)/Comprehensive T Cell Vaccine Immune Monitoring Consortium
(CTVIMC) grant from the Bill & Melinda Gates Foundation (Grant ID#
OPP1032325).
NR 31
TC 9
Z9 9
U1 0
U2 5
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0022-1759
EI 1872-7905
J9 J IMMUNOL METHODS
JI J. Immunol. Methods
PD JUL
PY 2014
VL 409
SI SI
BP 107
EP 116
DI 10.1016/j.jim.2014.04.005
PG 10
WC Biochemical Research Methods; Immunology
SC Biochemistry & Molecular Biology; Immunology
GA AO7QW
UT WOS:000341548700013
PM 24787274
ER
PT J
AU Maurer, EP
Brekke, L
Pruitt, T
Thrasher, B
Long, J
Duffy, P
Dettinger, M
Cayan, D
Arnold, J
AF Maurer, E. P.
Brekke, L.
Pruitt, T.
Thrasher, B.
Long, J.
Duffy, P.
Dettinger, M.
Cayan, D.
Arnold, J.
TI AN ENHANCED ARCHIVE FACILITATING CLIMATE IMPACTS AND ADAPTATION ANALYSIS
SO BULLETIN OF THE AMERICAN METEOROLOGICAL SOCIETY
LA English
DT Article
ID CHANGE SCENARIOS; CALIFORNIA; FUTURE; PRECIPITATION; INFORMATION;
SENSITIVITY; MODELS; TEMPERATURE; VARIABILITY; PROJECTIONS
AB We describe the expansion of a publicly available archive of downscaled climate and hydrology projections for the United States. Those studying or planning to adapt to future climate impacts demand downscaled climate model output for local or regional use. The archive we describe attempts to fulfill this need by providing data in several formats, selectable to meet user needs. Our archive has served as a resource for climate impacts modelers, water managers, educators, and others. Over 1,400 individuals have transferred more than 50 TB of data from the archive. In response to user demands, the archive has expanded from monthly downscaled data to include daily data to facilitate investigations of phenomena sensitive to daily to monthly temperature and precipitation, including extremes in these quantities. New developments include downscaled output from the new Coupled Model Intercomparison Project phase 5 (CMIP5) climate model simulations at both the monthly and daily time scales, as well as simulations of surface hydrological variables. The web interface allows the extraction of individual projections or ensemble statistics for user-defined regions, promoting the rapid assessment of model consensus and uncertainty for future projections of precipitation, temperature, and hydrology. The archive is accessible online (http://gdo-dcp.ucllnl.org/downscaled_cmip_projections).
C1 [Maurer, E. P.] Santa Clara Univ, Dept Civil Engn, Santa Clara, CA 95053 USA.
[Brekke, L.; Pruitt, T.] US Bur Reclamat, Tech Serv Ctr 86 68520, Denver, CO 80225 USA.
[Thrasher, B.] Climate Analyt Grp, Palo Alto, CA USA.
[Thrasher, B.] Climate Cent, Princeton, NJ USA.
[Long, J.; Duffy, P.] Lawrence Livermore Natl Lab, Livermore, CA USA.
[Dettinger, M.; Cayan, D.] US Geol Survey, La Jolla, CA USA.
[Dettinger, M.; Cayan, D.] Univ Calif San Diego, Scripps Inst Oceanog, Div Climate Atmospher Sci & Phys Oceanog, La Jolla, CA 92093 USA.
[Arnold, J.] US Army Corps Engineers, Inst Water Resources, Alexandria, VA USA.
RP Maurer, EP (reprint author), Santa Clara Univ, Dept Civil Engn, 500 El Camino Real, Santa Clara, CA 95053 USA.
EM emaurer@engr.scu.edu
RI Maurer, Edwin/C-7190-2009;
OI Maurer, Edwin/0000-0001-7134-487X; Thrasher, Bridget/0000-0002-3961-1971
FU Bureau of Reclamation's Science and Technology Program; WaterSMART
grants; California Energy Commission (CEC); U.S. Department of the
Interior Southwest Climate Science Center
FX We acknowledge the World Climate Research Programme's Working Group on
Coupled Modelling, which is responsible for CMIP, and we thank the
climate modeling groups for producing and making available their model
output. For CMIP the U.S. Department of Energy's Program for Climate
Model Diagnosis and Intercomparison provides coordinating support and
led development of software infrastructure in partnership with the
Global Organization for Earth System Science Portals. Portions of the
archive dataset were produced using computational facilities of the NASA
Earth Exchange (www.nex.nasa.gov). This work was supported by the Bureau
of Reclamation's Science and Technology Program (data service
development) and by WaterSMART grants to develop Climate Data Analysis
Tools. Support was also provided by the California Energy Commission
(CEC)-funded California Climate Change Center under the CEC PIER Program
and by the U.S. Department of the Interior Southwest Climate Science
Center.
NR 57
TC 14
Z9 14
U1 2
U2 19
PU AMER METEOROLOGICAL SOC
PI BOSTON
PA 45 BEACON ST, BOSTON, MA 02108-3693 USA
SN 0003-0007
EI 1520-0477
J9 B AM METEOROL SOC
JI Bull. Amer. Meteorol. Soc.
PD JUL
PY 2014
VL 95
IS 7
BP 1011
EP +
DI 10.1175/BAMS-D-13-00126.1
PG 10
WC Meteorology & Atmospheric Sciences
SC Meteorology & Atmospheric Sciences
GA AO0ED
UT WOS:000340981000010
ER
PT J
AU Garcia-Reyero, N
Ekman, DR
Habib, BT
Villeneuve, DL
Collette, TW
Bencic, DC
Ankley, GT
Perkins, EJ
AF Garcia-Reyero, Natalia
Ekman, Drew R.
Habib, B. Tanwir
Villeneuve, Daniel L.
Collette, Timothy W.
Bencic, David C.
Ankley, Gerald T.
Perkins, Edward J.
TI Integrated approach to explore the mechanisms of aromatase inhibition
and recovery in fathead minnows (Pimephales promelas)
SO GENERAL AND COMPARATIVE ENDOCRINOLOGY
LA English
DT Article
DE Fathead minnow; Aromatase; Fadrozole; Transcriptomics; Metabolomics;
Integrative analysis
ID GROWTH-FACTOR-I; GENE-EXPRESSION; SEX-DIFFERENTIATION;
ENERGY-METABOLISM; MOLECULAR-BIOLOGY; ORYZIAS-LATIPES; MESSENGER-RNA;
SPARUS-AURATA; KGN CELLS; FISH
AB Aromatase, a member of the cytochrome P450 superfamily, is a key enzyme in estradiol synthesis that catalyzes the aromatization of androgens into estrogens in ovaries. Here, we used an integrated approach to assess the mechanistic basis of the direct effects of aromatase inhibition, as well as adaptation and recovery processes in fish. We exposed female fathead minnows (Pimephales promelas) via the water to 30 mu g/L of a model aromatase inhibitor, fadrozole, during 8 days (exposure phase). Fish were then held in clean water for 8 more days (recovery phase). Samples were collected at 1, 2, 4, and 8 days of both the exposure and the recovery phases. Transcriptomics, metabolomics, and network inference were used to understand changes and infer connections at the transcript and metabolite level in the ovary. Apical end-points directly indicative of endocrine function, such as plasma estradiol, testosterone, and vitellogenin levels were also measured. An integrated analysis of the data revealed changes in gene expression consistent with increased testosterone in fadrozole-exposed ovaries. Metabolites such as glycogen and taurine were strongly correlated with increased testosterone levels. Comparison of in vivo and ex vivo steroidogenesis data suggested the accumulation of steroidogenic enzymes, including aromatase, as a mechanism to compensate for aromatase inhibition. (C) 2014 Elsevier Inc. All rights reserved.
C1 [Garcia-Reyero, Natalia] Mississippi State Univ, Inst Genom Biocomp & Biotechnol, Starkville, MS 39759 USA.
[Ekman, Drew R.; Collette, Timothy W.] US EPA, Off Res & Dev, Natl Exposure Res Lab, Athens, GA 30605 USA.
[Habib, B. Tanwir] Badger Tech Serv, San Antonio, TX 78216 USA.
[Villeneuve, Daniel L.; Ankley, Gerald T.] US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Midcontinent Ecol Div, Duluth, MN USA.
[Bencic, David C.] US EPA, Off Res & Dev, Natl Exposure Res Lab, Ecol Exposures Res Div, Cincinnati, OH 45268 USA.
[Perkins, Edward J.] US Army Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA.
RP Garcia-Reyero, N (reprint author), 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA.
EM nvinas@igbb.msstate.edu
FU US Army Environmental Quality Research Program [BAA 11-4838]
FX We thank many scientists who contributed to generation of aspects of the
data described herein, including N. Mueller, D. Martinovic, E. Mayknen,
M. Kahl, K. Jensen, E. Durhan, and J. Cavallin. This work was funded by
the US Army Environmental Quality Research Program (including BAA
11-4838). Permission for publishing this information has been granted by
the Chief of Engineers. Although this paper has been approved for
publication by the US EPA, the views expressed herein do not necessarily
reflect EPA positions or policy.
NR 77
TC 7
Z9 7
U1 1
U2 21
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0016-6480
EI 1095-6840
J9 GEN COMP ENDOCR
JI Gen. Comp. Endocrinol.
PD JUL 1
PY 2014
VL 203
SI SI
BP 193
EP 202
DI 10.1016/j.ygcen.2014.03.022
PG 10
WC Endocrinology & Metabolism
SC Endocrinology & Metabolism
GA AO1LJ
UT WOS:000341073300022
PM 24704562
ER
PT J
AU Garcia-Reyero, N
Tingaud-Sequeira, A
Cao, MX
Zhu, ZY
Perkins, EJ
Hu, W
AF Garcia-Reyero, Natalia
Tingaud-Sequeira, Angele
Cao, Mengxi
Zhu, Zuoyan
Perkins, Edward J.
Hu, Wei
TI Endocrinology: Advances through omics and related technologies
SO GENERAL AND COMPARATIVE ENDOCRINOLOGY
LA English
DT Article
DE Omics; Reproduction; Transgenic organisms; Integrative systems biology
ID ZEBRAFISH DANIO-RERIO; SALMON ONCORHYNCHUS-KISUTCH; MINNOWS
PIMEPHALES-PROMELAS; GROWTH-HORMONE SYNTHESIS; PITUITARY-GONADAL AXIS;
GENE-EXPRESSION; DAPHNIA-MAGNA; MESSENGER-RNA; SYSTEMS BIOLOGY;
RAINBOW-TROUT
AB The rapid development of new omics technologies to measure changes at genetic, transcriptomic, proteomic, and metabolomics levels together with the evolution of methods to analyze and integrate the data at a systems level are revolutionizing the study of biological processes. Here we discuss how new approaches using omics technologies have expanded our knowledge especially in nontraditional models. Our increasing knowledge of these interactions and evolutionary pathway conservation facilitates the use of nontraditional species, both invertebrate and vertebrate, as new model species for biological and endocrinology research. The increasing availability of technology to create organisms overexpressing key genes in endocrine function allows manipulation of complex regulatory networks such as growth hormone (GH) in transgenic fish where disregulation of GH production to produce larger fish has also permitted exploration of the role that GH plays in testis development, suggesting that it does so through interactions with insulin-like growth factors. The availability of omics tools to monitor changes at nearly any level in any organism, manipulate gene expression and behavior, and integrate data across biological levels, provides novel opportunities to explore endocrine function across many species and understand the complex roles that key genes play in different aspects of the endocrine function. (C) 2014 Elsevier Inc. All rights reserved.
C1 [Garcia-Reyero, Natalia] Mississippi State Univ, Inst Genom Biocomp & Biotechnol, Starkville, MS 39759 USA.
[Tingaud-Sequeira, Angele] Univ Bordeaux, Lab MRMG, F-33405 Talence, France.
[Cao, Mengxi; Zhu, Zuoyan; Hu, Wei] Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China.
[Cao, Mengxi] Univ Chinese Acad Sci, Beijing 100049, Peoples R China.
[Perkins, Edward J.] US Army Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA.
RP Garcia-Reyero, N (reprint author), 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA.
EM nvinas@igbb.msstate.edu
RI TINGAUD-SEQUEIRA, Angela/M-6023-2014
FU US Army Environmental Quality Research Program [BAA 11-4838]; "863" High
Technology Project [2011AA100404]; National Natural Science Foundation
[30930069]; Development Plan of the State Key Fundamental Research of
China [2010CB126302]; Key Research Program of the Chinese Academy of
Sciences [KSCX2-EW-N-004]; Conseil Regional d'Aquitaine, France
[200881301031/TOD project]; Agence Nationale de la Recherche (ANR)
[2010BLAN 1126 01/LIGENAX project]
FX This work was funded by the US Army Environmental Quality Research
Program (including BAA 11-4838). Permission for publishing this
information has been granted by the Chief of Engineers. This work was
also supported financially by the "863" High Technology Project (Grant
No. 2011AA100404), National Natural Science Foundation (Grant No.
30930069), the Development Plan of the State Key Fundamental Research of
China (Grant No. 2010CB126302), and the Key Research Program of the
Chinese Academy of Sciences (Grant No. KSCX2-EW-N-004). In addition,
this work was supported by the Conseil Regional d'Aquitaine, France
(Grant No. 200881301031/TOD project) and the Agence Nationale de la
Recherche (ANR Grant No. 2010BLAN 1126 01/LIGENAX project).
NR 172
TC 4
Z9 4
U1 4
U2 25
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0016-6480
EI 1095-6840
J9 GEN COMP ENDOCR
JI Gen. Comp. Endocrinol.
PD JUL 1
PY 2014
VL 203
SI SI
BP 262
EP 273
DI 10.1016/j.ygcen.2014.03.042
PG 12
WC Endocrinology & Metabolism
SC Endocrinology & Metabolism
GA AO1LJ
UT WOS:000341073300029
PM 24726988
ER
PT J
AU Pasiakos, SM
Carbone, JW
AF Pasiakos, Stefan M.
Carbone, John W.
TI Assessment of Skeletal Muscle Proteolysis and the Regulatory Response to
Nutrition and Exercise
SO IUBMB LIFE
LA English
DT Review
DE ubiquitin proteasome; lysosomes; protein breakdown; exercise; amino
acids
ID UBIQUITIN-PROTEASOME PATHWAY; FRACTIONAL BREAKDOWN RATE;
AMINO-ACID-TRANSPORT; RATE IN-VIVO; RESISTANCE EXERCISE;
PROTEIN-SYNTHESIS; ENDURANCE EXERCISE; ANABOLIC RESPONSE; LYSOSOMAL
PROTEOLYSIS; DIETARY-PROTEIN
AB Skeletal muscle proteolysis is highly regulated, involving complex intramuscular proteolytic systems that recognize and degrade muscle proteins, and recycle free amino acid precursors for protein synthesis and energy production. Autophagylysosomal, calpain, and caspase systems are contributors to muscle proteolysis, although the ubiquitin proteasome system (UPS) is the primary mechanism by which actomyosin fragments are degraded in healthy muscle. The UPS is sensitive to mechanical force and nutritional deprivation, as recent reports have demonstrated increased proteolytic gene expression and activity of the UPS in response to resistance and endurance exercise, and short-term negative energy balance. However, consuming dietary protein alone (or free amino acids), or as a primary component of a mixed meal, may attenuate intramuscular protein loss by down-regulating proteolytic gene expression and the catabolic activity of the UPS. Although these studies provide novel insight regarding the intramuscular regulation of skeletal muscle mass, the role of proteolysis in the regulation of skeletal muscle protein turnover in healthy human muscle is not well described. This article provides a contemporary review of the intramuscular regulation of skeletal muscle proteolysis in healthy muscle, methodological approaches to assess proteolysis, and highlights the effects of nutrition and exercise on skeletal muscle proteolysis. (C) 2014 IUBMB Life, 66(7): 478-484, 2014
C1 [Pasiakos, Stefan M.] US Army, Inst Environm Med, Mil Nutr Div, Natick, MA 01760 USA.
[Carbone, John W.] Eastern Michigan Univ, Sch Hlth Sci, Ypsilanti, MI 48197 USA.
RP Pasiakos, SM (reprint author), 15 Kansas St Bldg 42, Natick, MA 01760 USA.
EM stefan.pasiakos@us.army.mil
RI Pasiakos, Stefan/E-6295-2014
OI Pasiakos, Stefan/0000-0002-5378-5820
FU US Army Military Research and Material Command; Eastern Michigan
University College of Health and Human Services
FX The authors thank Dr. Andrew Young and Dr. Scott Montain for their
critical review in support of the development of this manuscript. All
authors have read and approved the final manuscript. This work has been
supported by the US Army Military Research and Material Command and the
Eastern Michigan University College of Health and Human Services. The
opinions or assertions contained herein are the private views of the
authors and are not to be construed as official or as reflecting the
views of the Army or the Department of Defense. Any citations of
commercial organizations and trade names in this report do not
constitute an official Department of the Army endorsement of approval of
the products or services of these organizations.
NR 77
TC 6
Z9 7
U1 2
U2 12
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1521-6543
EI 1521-6551
J9 IUBMB LIFE
JI IUBMB Life
PD JUL
PY 2014
VL 66
IS 7
BP 478
EP 484
DI 10.1002/iub.1291
PG 7
WC Biochemistry & Molecular Biology; Cell Biology
SC Biochemistry & Molecular Biology; Cell Biology
GA AN4RK
UT WOS:000340575200005
PM 25052691
ER
PT J
AU Cooper, D
Troth, T
Chin, EJ
Hughes, J
AF Cooper, David
Troth, Thomas
Chin, Eric J.
Hughes, John
TI Graduate Medical Education in Combat Support Hospitals: An Enlightening
Experience in a British-Led Combat Support Hospital
SO MILITARY MEDICINE
LA English
DT Editorial Material
ID MILITARY OPERATIONS; US MILITARY; SURGEON; RESUSCITATION; AFGHANISTAN;
TRAUMA; WAR; UK
C1 [Cooper, David; Troth, Thomas] Bast Hosp, Fleet Post Off, APO, AE 09372 USA.
[Chin, Eric J.; Hughes, John] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA.
RP Cooper, D (reprint author), Bast Hosp, Fleet Post Off, APO, AE 09372 USA.
NR 9
TC 1
Z9 1
U1 0
U2 0
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
EI 1930-613X
J9 MIL MED
JI Milit. Med.
PD JUL
PY 2014
VL 179
IS 7
BP 697
EP 701
DI 10.7205/MILMED-D-13-00411
PG 5
WC Medicine, General & Internal
SC General & Internal Medicine
GA AN7UN
UT WOS:000340806600001
PM 25003850
ER
PT J
AU Moe, CD
Keiser, PB
AF Moe, Christopher D.
Keiser, Paul B.
TI Should US Troops Routinely Get Rabies Pre-Exposure Prophylaxis?
SO MILITARY MEDICINE
LA English
DT Editorial Material
ID VACCINE; IMMUNIZATION; ADJUVANT; FUTURE
C1 [Moe, Christopher D.] Brigade Med Operat, St Airborne Div 101st, Brigade Combat Team 1st, Fort Campbell, KY 42223 USA.
[Keiser, Paul B.] Walter Reed Army Inst Res, Viral Dis Branch, Silver Spring, MD 20910 USA.
RP Moe, CD (reprint author), Brigade Med Operat, St Airborne Div 101st, Brigade Combat Team 1st, Bldg A3781,53rd St, Fort Campbell, KY 42223 USA.
NR 17
TC 0
Z9 0
U1 1
U2 2
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
EI 1930-613X
J9 MIL MED
JI Milit. Med.
PD JUL
PY 2014
VL 179
IS 7
BP 702
EP 703
DI 10.7205/MILMED-D-14-00053
PG 2
WC Medicine, General & Internal
SC General & Internal Medicine
GA AN7UN
UT WOS:000340806600002
PM 25003851
ER
PT J
AU Dailey, JI
Stanfa-Brew, MR
AF Dailey, Jason I.
Stanfa-Brew, Meffissa R.
TI Telebehavioral Health in Afghanistan
SO MILITARY MEDICINE
LA English
DT Article
ID CARE; MILITARY
AB Providing behavioral health care to numerous beneficiaries spread over a large and dangerous area is a unique and challenging responsibility faced by the U.S. Army in the deployed environment. We describe the use of telebehavioral health as one tool available to behavioral health officers in Afghanistan to reach remote service members when face-to-face encounters are not possible or practical. Finally, challenges to the current telebehavioral system established during Operation Enduring Freedom are discussed, with recommendations made for implementation in future deployed settings.
C1 [Dailey, Jason I.] Air Assault, Airborne Div 101st, Div Surg Sect, Fort Campbell, KY 42223 USA.
[Stanfa-Brew, Meffissa R.] US Army, Clin & Tech Expertise Div, Hlth Facil Planning Agcy, Falls Church, VA 22042 USA.
RP Dailey, JI (reprint author), Air Assault, Airborne Div 101st, Div Surg Sect, 6906 A Shan Valley Rd, Fort Campbell, KY 42223 USA.
NR 6
TC 0
Z9 0
U1 0
U2 1
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
EI 1930-613X
J9 MIL MED
JI Milit. Med.
PD JUL
PY 2014
VL 179
IS 7
BP 708
EP 710
DI 10.7205/MILMED-D-13-00538
PG 3
WC Medicine, General & Internal
SC General & Internal Medicine
GA AN7UN
UT WOS:000340806600004
PM 25003853
ER
PT J
AU Donelan, K
Romano, C
DesRoches, C
Applebaum, S
Ward, JRM
Schoneboom, BA
Hinshaw, AS
AF Donelan, Karen
Romano, Carol
DesRoches, Catherine
Applebaum, Sandra
Ward, Johanna R. M.
Schoneboom, Bruce A.
Hinshaw, Ada Sue
TI National Surveys of Military Personnel, Nursing Students, and the
Public: Drivers of Military Nursing Careers (vol 179, pg 565, 2014)
SO MILITARY MEDICINE
LA English
DT Correction
C1 [Donelan, Karen] Massachusetts Gen Hosp, Mongan Inst Hlth Policy, Boston, MA 02114 USA.
[Romano, Carol; Hinshaw, Ada Sue] Uniformed Serv Univ Hlth Sci, Grad Sch Nursing, Bethesda, MD 20814 USA.
[DesRoches, Catherine] Vanderbilt Univ, Ctr Med, Ctr Interdisciplinary Hlth Workforce Studies, Inst Med & Publ Hlth, Nashville, TN 37203 USA.
[Applebaum, Sandra] Math Policy Res, Cambridge, MA 02139 USA.
[Ward, Johanna R. M.] Harris Interact Inc, New York, NY 10010 USA.
[Schoneboom, Bruce A.] US Army, Med Res Inst Chem Def, Aberdeen Proving Ground, MD 21010 USA.
RP Donelan, K (reprint author), Massachusetts Gen Hosp, Mongan Inst Hlth Policy, 50 Staniford St,9th floor, Boston, MA 02114 USA.
NR 1
TC 0
Z9 0
U1 1
U2 1
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
EI 1930-613X
J9 MIL MED
JI Milit. Med.
PD JUL
PY 2014
VL 179
IS 7
BP 792
EP 792
PG 1
WC Medicine, General & Internal
SC General & Internal Medicine
GA AN7UN
UT WOS:000340806600024
ER
PT J
AU Hout, JJ
White, DW
Artino, AR
Knapik, JJ
AF Hout, Joseph J.
White, Duvel W.
Artino, Anthony R.
Knapik, Joseph J.
TI o-Chlorobenzylidene Malononitrile (CS Riot Control Agent) Associated
Acute Respiratory Illnesses in a US Army Basic Combat Training Cohort
SO MILITARY MEDICINE
LA English
DT Article
ID TEAR GAS; INFECTION; TRAINEES; DISEASES
AB Acute respiratory illnesses (ARIs) are among the leading causes for hospital visits in U.S. military training populations and historically peak during U.S. Army Basic Combat Training (B CT) following mandatory exposure to the riot control agent o-chlorobenzylidene malononitrile (CS). This observational prospective cohort studied the association between CS exposures and ART-related health outcomes in 6,723 U.S. Army recruits attending BCT at Fort Jackson, South Carolina from August 1 to September 25, 2012 by capturing and linking the incidence of ART before and after the mask confidence chamber to CS exposure data. Recruits had a significantly higher risk (risk ratio = 2.44; 95% confidence interval =1.74, 3.43) of being diagnosed with ART following exposure to CS compared to the period of training preceding exposure, and incidence of ART after CS exposure was dependent on the CS exposure concentration (p = 0.03). There was a significant pre-/postexposure ART difference across all CS concentration levels (p < 0.01), however, no significant differences were detected among these rate ratios (p = 0.72). As CS exposure is positively associated with ART health outcomes in this population, interventions designed to reduce respiratory exposures could result in decreased hospital burden and lost training time in the U.S. Army BCT population.
C1 [Hout, Joseph J.; White, Duvel W.; Artino, Anthony R.] Uniformed Serv Univ Hlth Sci, Dept Prevent Med & Biometr, Bethesda, MD 20814 USA.
[Knapik, Joseph J.] US Army, Inst Publ Hlth, Aberdeen Proving Ground, MD 21010 USA.
RP Hout, JJ (reprint author), Uniformed Serv Univ Hlth Sci, Dept Prevent Med & Biometr, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA.
OI Artino, Anthony/0000-0003-2661-7853
FU U.S. Army Medical Command, Office of the Surgeon General, Falls Church,
Virginia
FX This work was sponsored by the U.S. Army Medical Command, Office of the
Surgeon General, Falls Church, Virginia.
NR 23
TC 3
Z9 3
U1 0
U2 5
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
EI 1930-613X
J9 MIL MED
JI Milit. Med.
PD JUL
PY 2014
VL 179
IS 7
BP 793
EP 798
DI 10.7205/MILMED-D-13-00514
PG 6
WC Medicine, General & Internal
SC General & Internal Medicine
GA AN7UN
UT WOS:000340806600026
PM 25003867
ER
PT J
AU Evanson, JR
Guyton, MK
Oliver, DL
Hire, JM
Topolski, RL
Zumbrun, SD
McPherson, JC
Bojescul, JA
AF Evanson, J. Richard
Guyton, M. Kelly
Oliver, David L.
Hire, Justin M.
Topolski, Richard L.
Zumbrun, Steven D.
McPherson, James C.
Bojescul, John A.
TI Gender and Age Differences in Growth Factor Concentrations From
Platelet-Rich Plasma in Adults
SO MILITARY MEDICINE
LA English
DT Article
ID SPORTS-MEDICINE; TENDON; GENE; SEX; PROTEINS; TEARS
AB The use of platelet-rich plasma (PRP) to facilitate healing of orthopedic-related injuries has gained popularity; however, the clinical benefits are not consistent. Differences may result from variations in growth factor (GF) levels in normal populations. The purpose of this study was to determine if GF levels present in activated PRP preparations differed by gender and age (<= 25 versus >25 years) in a healthy population (N = 102). All GFs analyzed (epidermal growth factor [EGF], hepatocyte growth factor [HGF], insulin growth factor-1 [IGF-1], platelet-derived growth factor-AB [PDGF-AB], platelet-derived growth factor-BB [PDGF-BB], transforming growth factor beta-1 [TGF beta-1], and vascular endothelial growth factor) had higher levels for females and for those <= 25 years old. Of the GFs tested, four of seven were significantly higher (p < 0.05) for females (EGF, HGF, IGF-1, PDGF-BB), the most significant being IGF-1 (female, 85.0; male, 69.3 ng/mL; p < 0.01). Five of seven GFs achieved significance (p < 0.05) for people <= 25 years old (EGF, IGF-1, PDGP-AB, PDGF-BB, and TGF beta-1), with IGF and PDGF-AB achieving p < 0.001 (<= 25 years, 85.1; >25 years, 56.8, and <= 25 years, 7.66; >25 years, 5.77 ng/mL, respectively). Finally, for both genders, most of the GFs were positively correlated with all GFs. This study demonstrated that both age and gender account for variations in specific GFs present in PEP, and this may partially explain some of the inconsistent results of PEP clinical trials.
C1 [Evanson, J. Richard; Oliver, David L.; Hire, Justin M.; Bojescul, John A.] Dwight D Eisenhower Army Med Ctr, Dept Orthopaed, Ft Gordon, GA 30905 USA.
[Guyton, M. Kelly; Topolski, Richard L.; Zumbrun, Steven D.; McPherson, James C.] Dept Clin Invest, Ft Gordon, GA 30905 USA.
RP Evanson, JR (reprint author), Dwight D Eisenhower Army Med Ctr, Dept Orthopaed, 300 Hosp Rd, Ft Gordon, GA 30905 USA.
FU Department of Clinical Investigation at Fort Gordon
FX We would like to thank the military and civilian staff of Kendrick
Memorial Donor Center for their enormous assistance with this project.
The funding for this project was acquired through the Department of
Clinical Investigation at Fort Gordon.
NR 32
TC 3
Z9 3
U1 0
U2 3
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
EI 1930-613X
J9 MIL MED
JI Milit. Med.
PD JUL
PY 2014
VL 179
IS 7
BP 799
EP 805
DI 10.7205/MILMED-D-13-00336
PG 7
WC Medicine, General & Internal
SC General & Internal Medicine
GA AN7UN
UT WOS:000340806600027
PM 25003868
ER
PT J
AU Garamszegi, S
Yen, JY
Honko, AN
Geisbert, JB
Rubins, KH
Geisbert, TW
Xia, Y
Hensley, LE
Connor, JH
AF Garamszegi, Sara
Yen, Judy Y.
Honko, Anna N.
Geisbert, Joan B.
Rubins, Kathleen H.
Geisbert, Thomas W.
Xia, Yu
Hensley, Lisa E.
Connor, John H.
TI Transcriptional Correlates of Disease Outcome in Anticoagulant-Treated
Non-Human Primates Infected with Ebolavirus
SO PLOS NEGLECTED TROPICAL DISEASES
LA English
DT Article
ID BINDING-PROTEIN-BETA; HEMORRHAGIC-FEVER; VIRUS INFECTION; HEPATITIS-C;
MARBURG VIRUSES; GENE-EXPRESSION; DENDRITIC CELLS; MICROARRAY DATA;
POSTEXPOSURE TREATMENT; CYNOMOLGUS MACAQUES
AB Ebola virus (EBOV) infection in humans and non-human primates (NHPs) is highly lethal, and there is limited understanding of the mechanisms associated with pathogenesis and survival. Here, we describe a transcriptomic analysis of NHPs that survived lethal EBOV infection, compared to NHPs that did not survive. It has been previously demonstrated that anticoagulant therapeutics increase the survival rate in EBOV-infected NHPs, and that the characteristic transcriptional profile of immune response changes in anticoagulant-treated NHPs. In order to identify transcriptional signatures that correlate with survival following EBOV infection, we compared the mRNA expression profile in peripheral blood mononuclear cells from EBOV-infected NHPs that received anticoagulant treatment, to those that did not receive treatment. We identified a small set of 20 genes that are highly confident predictors and can accurately distinguish between surviving and non-surviving animals. In addition, we identified a larger predictive signature of 238 genes that correlated with disease outcome and treatment; this latter signature was associated with a variety of host responses, such as the inflammatory response, T cell death, and inhibition of viral replication. Notably, among survival-associated genes were subsets of genes that are transcriptionally regulated by (1) CCAAT/enhancer-binding protein alpha, (2) tumor protein 53, and (3) megakaryoblastic leukemia 1 and myocardin-like protein 2. These pathways merit further investigation as potential transcriptional signatures of host immune response to EBOV infection.
C1 [Garamszegi, Sara; Xia, Yu; Connor, John H.] Boston Univ, Bioinformat Program, Boston, MA 02215 USA.
[Yen, Judy Y.; Connor, John H.] Boston Univ, Sch Med, Dept Microbiol, Boston, MA 02215 USA.
[Yen, Judy Y.; Connor, John H.] Boston Univ, Natl Emerging Infect Dis Labs, Boston, MA 02215 USA.
[Honko, Anna N.] US Army Med Res Inst Infect Dis, Frederick, MD USA.
[Geisbert, Joan B.; Geisbert, Thomas W.] Univ Texas Med Branch, Dept Microbiol & Immunol, Galveston, TX 77555 USA.
[Rubins, Kathleen H.] Natl Aeronaut & Space Adm, Houston, TX USA.
[Xia, Yu] McGill Univ, Dept Bioengn, Montreal, PQ, Canada.
[Hensley, Lisa E.] NIAID, Integrated Res Facil Ft Detrick, NIH, Frederick, MD USA.
RP Garamszegi, S (reprint author), Boston Univ, Bioinformat Program, Boston, MA 02215 USA.
EM jhconnor@bu.edu
OI Connor, John/0000-0002-8867-7256; Xia, Yu/0000-0002-5596-5518; Honko,
Anna/0000-0001-9165-148X
FU National Science Foundation (NSF) Integrative Graduate Education and
Research Traineeship [DGE-0654108]; NSF Graduate Research Fellowship
[DGE-0741448]; Pharmaceutical Research and Manufacturers of America
Foundation; Joint Science and Technology Office for Chemical and
Biological Defense; Defense Threat Reduction Agency [JSTO-CBD
4.0021.08.RD.B]; USAMRIID [19595, 188261]; JSTO-CBD
FX SG was supported by a fellowship from the National Science Foundation
(NSF) Integrative Graduate Education and Research Traineeship
(DGE-0654108) and an NSF Graduate Research Fellowship (DGE-0741448). YX
was supported by a Research Starter Grant in Informatics from the
Pharmaceutical Research and Manufacturers of America Foundation. Funding
for experimental animal studies was provided by the Joint Science and
Technology Office for Chemical and Biological Defense and the Defense
Threat Reduction Agency (JSTO-CBD 4.0021.08.RD.B). This work was
conducted at USAMRIID under project numbers 19595 and 188261 supported
by JSTO-CBD. The funders had no role in study design, data collection
and analysis, decision to publish, or preparation of the manuscript.
NR 83
TC 7
Z9 7
U1 0
U2 24
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1935-2735
J9 PLOS NEGLECT TROP D
JI Plos Neglect. Trop. Dis.
PD JUL
PY 2014
VL 8
IS 7
AR e3061
DI 10.1371/journal.pntd.0003061
PG 14
WC Infectious Diseases; Parasitology; Tropical Medicine
SC Infectious Diseases; Parasitology; Tropical Medicine
GA AN4IQ
UT WOS:000340551500076
PM 25079789
ER
PT J
AU Bayne, S
Lacouture, S
Lawson, K
Giesselmann, M
Scozzie, CJ
O'Brien, H
Ogunniyi, AA
AF Bayne, Stephen
Lacouture, Shelby
Lawson, Kevin
Giesselmann, Michael
Scozzie, Charles J.
O'Brien, Heather
Ogunniyi, Aderinto A.
TI An evaluation system for experimental silicon and silicon carbide super
gate turn off thyristors
SO REVIEW OF SCIENTIFIC INSTRUMENTS
LA English
DT Article
AB This paper describes the design and implementation of a small-scale pulsed power system specifically intended to evaluate the suitability of experimental silicon and silicon carbide high power Super Gate Turn Off thyristors for high action (500 A(2) s and above) pulsed power applications where energy is extracted from a storage element in a rapid and controlled manner. To this end, six of each type of device was placed in a controlled three phase rectifier circuit which was in turn connected to an aircraft ground power motor-generator set and subjected to testing protocols with varying power levels, while parameters such as offset firing angle were varied. (C) 2014 AIP Publishing LLC.
C1 [Bayne, Stephen; Lacouture, Shelby; Lawson, Kevin; Giesselmann, Michael] Texas Tech Univ, Dept Elect Engn, Lubbock, TX 79409 USA.
[Scozzie, Charles J.; O'Brien, Heather; Ogunniyi, Aderinto A.] US Army Res Lab, Adelphi, MD 20783 USA.
RP Bayne, S (reprint author), Texas Tech Univ, Dept Elect Engn, 1012 Boston Ave, Lubbock, TX 79409 USA.
FU Army Research Laboratory [W911NF-10-2-0018]
FX We would like to thank Army Research Laboratory (Contract No.
W911NF-10-2-0018) for supporting this work and for lending their
technical expertise.
NR 9
TC 0
Z9 0
U1 1
U2 3
PU AMER INST PHYSICS
PI MELVILLE
PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1,
MELVILLE, NY 11747-4501 USA
SN 0034-6748
EI 1089-7623
J9 REV SCI INSTRUM
JI Rev. Sci. Instrum.
PD JUL
PY 2014
VL 85
IS 7
AR 075107
DI 10.1063/1.4885449
PG 5
WC Instruments & Instrumentation; Physics, Applied
SC Instruments & Instrumentation; Physics
GA AO2SQ
UT WOS:000341176600054
PM 25085173
ER
PT J
AU Ingraham, JM
Deng, ZD
Li, X
Fu, T
McMichael, GA
Trumbo, BA
AF Ingraham, J. M.
Deng, Z. D.
Li, X.
Fu, T.
McMichael, G. A.
Trumbo, B. A.
TI A fast and accurate decoder for underwater acoustic telemetry
SO REVIEW OF SCIENTIFIC INSTRUMENTS
LA English
DT Article
ID SALMON; SYSTEM; TURBINES; PASSAGE; INSTRUMENTATION; SURVIVAL; TRACKING;
DESIGN
AB The Juvenile Salmon Acoustic Telemetry System, developed by the U. S. Army Corps of Engineers, Portland District, has been used to monitor the survival of juvenile salmonids passing through hydroelectric facilities in the Federal Columbia River Power System. Cabled hydrophone arrays deployed at dams receive coded transmissions sent from acoustic transmitters implanted in fish. The signals' time of arrival on different hydrophones is used to track fish in 3D. In this article, a new algorithm that decodes the received transmissions is described and the results are compared to results for the previous decoding algorithm. In a laboratory environment, the new decoder was able to decode signals with lower signal strength than the previous decoder, effectively increasing decoding efficiency and range. In field testing, the new algorithm decoded significantly more signals than the previous decoder and three-dimensional tracking experiments showed that the new decoder's time-of-arrival estimates were accurate. At multiple distances from hydrophones, the new algorithm tracked more points more accurately than the previous decoder. The new algorithm was also more than 10 times faster, which is critical for real-time applications on an embedded system. (C) 2014 AIP Publishing LLC.
C1 [Ingraham, J. M.; Deng, Z. D.; Li, X.; Fu, T.; McMichael, G. A.] Pacific NW Natl Lab, Richland, WA 99332 USA.
[Trumbo, B. A.] US Army Corps Engineers, Walla Walla, WA 99362 USA.
RP Deng, ZD (reprint author), Pacific NW Natl Lab, POB 999, Richland, WA 99332 USA.
EM zhiqun.deng@pnnl.gov
RI Deng, Daniel/A-9536-2011
OI Deng, Daniel/0000-0002-8300-8766
FU U.S. Army Corps of Engineers (USACE)
FX This research was funded by the U.S. Army Corps of Engineers (USACE). We
greatly appreciate the assistance of USACE staff members including
Martin Ahmann, Brad Eppard, Derek Fryer, Mike Langeslay, Steve Juhnke,
Marvin Shutters, and Jon Renholds. Critical assistance also was provided
by many staff members of the Pacific Northwest National Laboratory,
including Ki Won Jung, Jun Lu, Jayson Martinez, Mitchell Myjak, Mark
Weiland, and Maura Zimmerschied.
NR 25
TC 1
Z9 1
U1 0
U2 12
PU AMER INST PHYSICS
PI MELVILLE
PA 1305 WALT WHITMAN RD, STE 300, MELVILLE, NY 11747-4501 USA
SN 0034-6748
EI 1089-7623
J9 REV SCI INSTRUM
JI Rev. Sci. Instrum.
PD JUL
PY 2014
VL 85
IS 7
AR 074903
DI 10.1063/1.4891041
PG 8
WC Instruments & Instrumentation; Physics, Applied
SC Instruments & Instrumentation; Physics
GA AO2SQ
UT WOS:000341176600043
PM 25085162
ER
PT J
AU Baird, JK
RictitE, TL
Hoffman, SL
Palmieri, JR
Franice-Vellasante, E
Ohrt, C
Punjabi, N
Maguire, JD
Elyazar, I
Dennis, DT
Basri, H
Sutanto, I
Chand, K
Andersen, E
Sismadi, P
Fryauff, DJ
AF Baird, J. Kevin
RictitE, Thomas L.
Hoffman, Stephen L.
Palmieri, James R.
Franice-Vellasante, Eileen
Ohrt, Colin
Punjabi, Narian
Maguire, Jason D.
Elyazar, Iqbal
Dennis, David T.
Basri, Hasan
Sutanto, Inge
Chand, Krism
Andersen, Ellen
Sismadi, Prianto
Fryauff, David J.
TI Purnomo Projodipuro 11 April 1933-10 May 2013 Obituary
SO COMPARATIVE PARASITOLOGY
LA English
DT Biographical-Item
C1 [Baird, J. Kevin; Elyazar, Iqbal; Basri, Hasan; Chand, Krism] Eijkman Oxford Clin Res Unit, Jakarta, Indonesia.
[Hoffman, Stephen L.] Sanaria Inc, Rockville, MD USA.
[Palmieri, James R.] Virginia Tech Univ, Blacksburg, VA USA.
[Franice-Vellasante, Eileen; Fryauff, David J.] Naval Med Res Ctr, Silver Spring, MD USA.
[Ohrt, Colin] Walter Reed Army Inst Res, Silver Spring, MD USA.
[Punjabi, Narian] Int SOS, Jakarta, Indonesia.
[Maguire, Jason D.] Portsmouth Naval Hosp, Portsmouth, VA USA.
[Dennis, David T.] US Ctr Dis Control, Ft Collins, CO USA.
[Sutanto, Inge] Univ Indonesia, Fac Med, Jakarta, Indonesia.
[Andersen, Ellen] USN Ret, MSC, LCDR, Washington, DC USA.
[Sismadi, Prianto] Sismadi Hlth Sci & Res Inst, Jakarta, Indonesia.
[Fryauff, David J.] Naval Med Res Ctr, Silver Spring, MD USA.
RP Baird, JK (reprint author), Eijkman Oxford Clin Res Unit, Jakarta, Indonesia.
NR 1
TC 0
Z9 0
U1 0
U2 0
PU HELMINTHOLOGICAL SOC WASHINGTON
PI LAWRENCE
PA C/O ALLEN PRESS INC, 1041 NEW HAMPSHIRE ST, ACCT# 141866, LAWRENCE, KS
66044 USA
SN 1525-2647
EI 1938-2952
J9 COMP PARASITOL
JI Comp. Parasitol.
PD JUL
PY 2014
VL 81
IS 2
BP 291
EP 294
PG 4
WC Parasitology; Zoology
SC Parasitology; Zoology
GA AM9WC
UT WOS:000340230700024
ER
PT J
AU Keyser, BM
Andres, DK
Holmes, WW
Paradiso, D
Appell, A
Letukas, VA
Benton, B
Clark, OE
Gao, XG
Ray, P
Anderson, DR
Ray, R
AF Keyser, Brian M.
Andres, Devon K.
Holmes, Wesley W.
Paradiso, Danielle
Appell, Ashley
Letukas, Valerie A.
Benton, Betty
Clark, Offie E.
Gao, Xiugong
Ray, Prabhati
Anderson, Dana R.
Ray, Radharaman
TI Mustard Gas Inhalation Injury: Therapeutic Strategy
SO INTERNATIONAL JOURNAL OF TOXICOLOGY
LA English
DT Review
DE sulfur mustard; inhalation; apoptosis; antioxidants; anti-inflammatory;
protease
ID ACUTE LUNG INJURY; 2-CHLOROETHYL ETHYL SULFIDE; EPITHELIAL-CELL
APOPTOSIS; INHALED SULFUR MUSTARD; NITRIC-OXIDE SYNTHASE;
ACETYL-L-CYSTEINE; GUINEA-PIGS; FAS LIGAND; OXIDATIVE STRESS;
PULMONARY-FIBROSIS
AB Mustard gas (sulfur mustard [SM], bis-[2-chloroethyl] sulfide) is a vesicating chemical warfare agent and a potential chemical terrorism agent. Exposure of SM causes debilitating skin blisters (vesication) and injury to the eyes and the respiratory tract; of these, the respiratory injury, if severe, may even be fatal. Therefore, developing an effective therapeutic strategy to protect against SM-induced respiratory injury is an urgent priority of not only the US military but also the civilian antiterrorism agencies, for example, the Homeland Security. Toward developing a respiratory medical countermeasure for SM, four different classes of therapeutic compounds have been evaluated in the past: anti-inflammatory compounds, antioxidants, protease inhibitors and antiapoptotic compounds. This review examines all of these different options; however, it suggests that preventing cell death by inhibiting apoptosis seems to be a compelling strategy but possibly dependent on adjunct therapies using the other drugs, that is, anti-inflammatory, antioxidant, and protease inhibitor compounds.
C1 [Keyser, Brian M.; Andres, Devon K.; Appell, Ashley; Letukas, Valerie A.; Benton, Betty; Clark, Offie E.; Ray, Radharaman] US Army Med Res Inst Chem Def, Div Res, Aberdeen Proving Ground, MD USA.
[Holmes, Wesley W.; Paradiso, Danielle; Anderson, Dana R.] US Army Med Res Inst Chem Def, Analyt Toxicol Div, Aberdeen Proving Ground, MD USA.
[Gao, Xiugong; Ray, Prabhati] Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD USA.
RP Ray, R (reprint author), US Army Med Res Inst Chem Def, Div Res, Cellular & Mol Biol Branch, 3100 Ricketts Point Rd, Aberdeen Proving Ground, MD 21010 USA.
EM radharaman.ray.civ@mail.mil
OI Andres, Devon/0000-0002-6823-4132
FU Defense Threat Reduction Agency-Joint Science and Technology Office,
Medical ST Division [CBM.RESP.01.10.RC.015]
FX This work was supported by the Defense Threat Reduction Agency-Joint
Science and Technology Office, Medical S&T Division [Grant
CBM.RESP.01.10.RC.015]. Additionally, this research was supported in
part by an appointment to the Postgraduate Research Participation
Program at the US Army Medical Research Institute of Chemical Defense
administered by the Oak Ridge Institute for Science and Education
through an interagency agreement between the US Department of Energy and
USAMRMC. We acknowledge LTC Derron A. Alves for his expertise in the
lung cast staining.
NR 91
TC 6
Z9 6
U1 1
U2 25
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1091-5818
EI 1092-874X
J9 INT J TOXICOL
JI Int. J. Toxicol.
PD JUL-AUG
PY 2014
VL 33
IS 4
BP 271
EP 281
DI 10.1177/1091581814532959
PG 11
WC Pharmacology & Pharmacy; Toxicology
SC Pharmacology & Pharmacy; Toxicology
GA AN4GK
UT WOS:000340545500003
PM 24801489
ER
PT J
AU Peng, LS
Adler, M
Demogines, A
Borrell, A
Liu, HS
Tao, L
Tepp, WH
Zhang, SC
Johnson, EA
Sawyer, SL
Dong, M
AF Peng, Lisheng
Adler, Michael
Demogines, Ann
Borrell, Andrew
Liu, Huisheng
Tao, Liang
Tepp, William H.
Zhang, Su-Chun
Johnson, Eric A.
Sawyer, Sara L.
Dong, Min
TI Widespread Sequence Variations in VAMP1 across Vertebrates Suggest a
Potential Selective Pressure from Botulinum Neurotoxins
SO PLOS PATHOGENS
LA English
DT Article
ID PERIPHERAL NERVOUS-SYSTEM; MEMBRANE-PROTEIN; RAT-BRAIN; NEUROTRANSMITTER
RELEASE; SYNAPTOBREVIN-I; MOTOR-NEURONS; R-SNARES; EXOCYTOSIS; PATTERNS;
CLEAVAGE
AB Botulinum neurotoxins (BoNT/A-G), the most potent toxins known, act by cleaving three SNARE proteins required for synaptic vesicle exocytosis. Previous studies on BoNTs have generally utilized the major SNARE homologues expressed in brain (VAMP2, syntaxin 1, and SNAP-25). However, BoNTs target peripheral motor neurons and cause death by paralyzing respiratory muscles such as the diaphragm. Here we report that VAMP1, but not VAMP2, is the SNARE homologue predominantly expressed in adult rodent diaphragm motor nerve terminals and in differentiated human motor neurons. In contrast to the highly conserved VAMP2, BoNT-resistant variations in VAMP1 are widespread across vertebrates. In particular, we identified a polymorphism at position 48 of VAMP1 in rats, which renders VAMP1 either resistant (I48) or sensitive (M48) to BoNT/D. Taking advantage of this finding, we showed that rat diaphragms with I48 in VAMP1 are insensitive to BoNT/D compared to rat diaphragms with M48 in VAMP1. This unique intra-species comparison establishes VAMP1 as a physiological toxin target in diaphragm motor nerve terminals, and demonstrates that the resistance of VAMP1 to BoNTs can underlie the insensitivity of a species to members of BoNTs. Consistently, human VAMP1 contains I48, which may explain why humans are insensitive to BoNT/D. Finally, we report that residue 48 of VAMP1 varies frequently between M and I across seventeen closely related primate species, suggesting a potential selective pressure from members of BoNTs for resistance in vertebrates.
C1 [Peng, Lisheng; Tao, Liang; Dong, Min] Harvard Univ, Dept Microbiol & Immunobiol, Sch Med, Southborough, MA 01772 USA.
[Peng, Lisheng; Tao, Liang; Dong, Min] New England Primate Res Ctr, Div Neuroscience, Southborough, MA USA.
[Adler, Michael; Borrell, Andrew] US Army Med Res Inst Chem Def, Neurobehav Toxicol Branch, Aberdeen Proving Ground, MD USA.
[Demogines, Ann; Sawyer, Sara L.] Univ Texas Austin, Dept Mol Biosci, Austin, TX 78712 USA.
[Liu, Huisheng; Zhang, Su-Chun] Univ Wisconsin, Dept Neurol, Waisman Ctr, Dept Neurosci, Madison, WI 53706 USA.
[Tepp, William H.; Johnson, Eric A.] Univ Wisconsin, Dept Bacteriol, Madison, WI 53706 USA.
RP Peng, LS (reprint author), Harvard Univ, Dept Microbiol & Immunobiol, Sch Med, Southborough, MA 01772 USA.
EM michael.adler2.civ@mail.mil; saras@austin.utexas.edu;
min_dong@hms.harvard.edu
FU NIH [RR000168, OD011103, 1R56AI097834, 1R21NS082830, 1R01NS080833,
R01-GM-093086]; American Cancer Society; Burroughs Wellcome Fund
FX This study was supported by the following NIH grants: RR000168 and
OD011103 (to the New England Primate Research Center), 1R56AI097834,
1R21NS082830, and 1R01NS080833 (to MD), R01-GM-093086 (to SLS). AD is
supported by an American Cancer Society Postdoctoral Fellowship. SLS
holds a Career Award in the Biomedical Sciences from the Burroughs
Wellcome Fund. The funders had no role in study design, data collection
and analysis, decision to publish, or preparation of the manuscript.
NR 35
TC 6
Z9 6
U1 1
U2 5
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1553-7366
EI 1553-7374
J9 PLOS PATHOG
JI PLoS Pathog.
PD JUL
PY 2014
VL 10
IS 7
AR e1004177
DI 10.1371/journal.ppat.1004177
PG 9
WC Microbiology; Parasitology; Virology
SC Microbiology; Parasitology; Virology
GA AN4IL
UT WOS:000340551000006
PM 25010769
ER
PT J
AU Olcese, SP
Derosa, R
Kern, SQ
Lustik, MB
Sterbis, JR
McMann, LP
AF Olcese, S. P.
Derosa, R.
Kern, S. Q.
Lustik, M. B.
Sterbis, J. R.
McMann, L. P.
TI Comparison of outcomes after TURP versus photoselective vaporization of
the prostate with respect to trainee involvement utilizing ACS NSQIP
SO PROSTATE CANCER AND PROSTATIC DISEASES
LA English
DT Article
ID HOLMIUM LASER ENUCLEATION; RANDOMIZED CLINICAL-TRIAL; EFFECT SURGICAL
TIMES; TRANSURETHRAL RESECTION; RESIDENT INVOLVEMENT; UNCOMPLICATED
APPENDICITIS; LAPAROSCOPIC APPENDECTOMY; COMPLICATION RATES; FOLLOW-UP;
HYPERPLASIA
AB BACKGROUND: Large Multicenter studies comparing outcomes between TURP and photoselective vaporization of the prostate (PVP) are sparse, with no studies having compared the influence of trainee involvement on these outcomes. Our objectives were to assess 30-day outcomes after TURP and PVP with respect to trainee involvement using an independent national surgical database.
METHODS: Using the American College of Surgeons National Surgical Quality Improvement Program (ACS NSQIP) data (2005-2011), 7893 men were identified who underwent TURP or PVP. Regression models were constructed to assess associations between surgical approach, risk-adjusted morbidity and individual complications. Relationships between operative approach, operative duration and duration of stay were also examined and subdivided based upon trainee level.
RESULTS: Of 7893 patients, 4950 (62.7%) underwent TURP and 2943 (37.3%) underwent PVP. TURP patients were older, more likely to have diabetes, cancer, history of steroid use and preoperative transfusion compared with PVP patients, who were more likely to have coronary artery disease or bleeding disorders. Risk-adjusted overall morbidity was similar; however, PVP was associated with less pneumonia (0.2% vs 0.5%, P<0.015), bleeding requiring transfusion (0.5% vs 1.8%, P<0.001) and return to the operating room (1.5% vs 2.2%, P<0.022). PVP patients also had shorter length of stay (0.8 vs 2.1 days, P<0.001). There were no significant differences in outcomes when a trainee was involved. Operative duration was similar for TURP and PVP when performed by an attending alone (52 vs 52 min, P<0.001), but was longer with trainee involvement, regardless of post-graduate year (PGY) level (P<0.001). Comparison of operative duration among trainee subgroups demonstrated longer operative times for the PGY 6-9 subgroup performing PVP when compared with other subgroups (P<0.003).
CONCLUSIONS: Within ACS NSQIP hospitals, TURP and PVP demonstrated similar risk-adjusted overall morbidity. Despite longer operative times for TURP and PVP with trainee involvement, there were no significant differences in outcomes.
C1 [Olcese, S. P.; Derosa, R.; Kern, S. Q.; Sterbis, J. R.; McMann, L. P.] Tripler Army Med Ctr, Dept Surg, Urol Serv, Honolulu, HI 96859 USA.
[Lustik, M. B.] Tripler Army Med Ctr, Dept Clin Invest, Honolulu, HI 96859 USA.
RP Olcese, SP (reprint author), Tripler Army Med Ctr, Dept Surg, 1 Jarrett White Rd, Honolulu, HI 96859 USA.
EM Seth.P.Olcese.mil@us.army.mil
NR 21
TC 1
Z9 1
U1 1
U2 3
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1365-7852
EI 1476-5608
J9 PROSTATE CANCER P D
JI Prostate Cancer Prostatic Dis.
PD JUL
PY 2014
VL 17
IS 3
BP 227
EP 232
DI 10.1038/pcan.2014.13
PG 6
WC Oncology; Urology & Nephrology
SC Oncology; Urology & Nephrology
GA AN3UL
UT WOS:000340514100003
PM 24732080
ER
PT J
AU Zhang, SS
AF Zhang, Sheng S.
TI Understanding of Sulfurized Polyacrylonitrile for Superior Performance
Lithium/Sulfur Battery
SO ENERGIES
LA English
DT Article
DE lithium-sulfur battery; sulfur cathode; sulfurized carbon; sulfurized
polyacrylonitrile; polysulfide
ID COMPOSITE CATHODE MATERIALS; CARBONATE-BASED ELECTROLYTE;
ELECTROCHEMICAL PERFORMANCE; CHARGE/DISCHARGE CHARACTERISTICS; POLYMER
ELECTROLYTE; LI/S BATTERIES; CAPACITY; GRAPHENE; STORAGE; CYCLE
AB Sulfurized polyacrylonitrile (SPAN) is one of the most important sulfurized carbon materials that can potentially be coupled with the carbonaceous anode to fabricate a safe and low cost "all carbon" lithium-ion battery. However, its chemical structure and electrochemical properties have been poorly understood. In this discussion, we analyze the previously published data in combination with our own results to propose a more reasonable chemical structure that consists of short -S-x- chains covalently bonded onto cyclized, partially dehydrogenated, and ribbon-like polyacrylonitrile backbones. The proposed structure fits all previous structural characterizations and explains many unique electrochemical phenomena that were observed from the Li/SPAN cells but have not been understood clearly.
C1 US Army Res Lab, Electrochem Branch, RDRL SED C, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA.
RP Zhang, SS (reprint author), US Army Res Lab, Electrochem Branch, RDRL SED C, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA.
EM shengshui.zhang.civ@mail.mil
RI Zhang, Sheng/A-4456-2012
OI Zhang, Sheng/0000-0003-4435-4110
NR 32
TC 19
Z9 19
U1 13
U2 122
PU MDPI AG
PI BASEL
PA POSTFACH, CH-4005 BASEL, SWITZERLAND
SN 1996-1073
J9 ENERGIES
JI Energies
PD JUL
PY 2014
VL 7
IS 7
BP 4588
EP 4600
DI 10.3390/en7074588
PG 13
WC Energy & Fuels
SC Energy & Fuels
GA AM6QH
UT WOS:000339989200031
ER
PT J
AU Valenti, MC
Torrieri, D
Talarico, S
AF Valenti, Matthew C.
Torrieri, Don
Talarico, Salvatore
TI A Direct Approach to Computing Spatially Averaged Outage Probability
SO IEEE COMMUNICATIONS LETTERS
LA English
DT Article
DE Outage probability; stochastic geometry; point processes; interference
modeling; fading
ID WIRELESS NETWORKS
AB This letter describes a direct method for computing the spatially averaged outage probability of a network with interferers located according to a point process and signals subject to fading. Unlike most common approaches, it does not require transforms such as a Laplace transform. Examples show how to directly obtain the outage probability in the presence of Rayleigh fading in networks whose interferers are drawn from binomial and Poisson point processes defined over arbitrary regions. We furthermore show that, by extending the arbitrary region to the entire plane, the result for Poisson point processes converges to the same expression found by Baccelli et al.
C1 [Valenti, Matthew C.; Talarico, Salvatore] W Virginia Univ, Morgantown, WV 26506 USA.
[Torrieri, Don] US Army Res Lab, Adelphi, MD 20783 USA.
RP Valenti, MC (reprint author), W Virginia Univ, Morgantown, WV 26506 USA.
EM valenti@ieee.org; don.j.torrieri.civ@mail.mil;
Salvatore.Talarico81@gmail.com
OI Valenti, Matthew/0000-0001-6089-0509
NR 11
TC 4
Z9 5
U1 0
U2 2
PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
PI PISCATAWAY
PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA
SN 1089-7798
EI 1558-2558
J9 IEEE COMMUN LETT
JI IEEE Commun. Lett.
PD JUL
PY 2014
VL 18
IS 7
BP 1103
EP 1106
DI 10.1109/LCOMM.2014.2317740
PG 4
WC Telecommunications
SC Telecommunications
GA AM8IE
UT WOS:000340116100004
ER
PT J
AU Zheng, Q
Cao, GH
La Porta, TF
Swami, A
AF Zheng, Qiang
Cao, Guohong
La Porta, Thomas F.
Swami, Ananthram
TI Cross-Layer Approach for Minimizing Routing Disruption in IP Networks
SO IEEE TRANSACTIONS ON PARALLEL AND DISTRIBUTED SYSTEMS
LA English
DT Article
DE Routing; failures; cross-layer; recovery; IP networks
ID WDM-BASED NETWORKS; FAILURES; DESIGN; PATH; PROTECTION; RECOVERY;
BACKBONE; SCHEME
AB Backup paths are widely used in IP networks to protect IP links from failures. However, existing solutions such as the commonly used independent model and Shared Risk Link Group (SRLG) model do not accurately reflect the correlation between IP link failures, and thus may not choose reliable backup paths. We propose a cross-layer approach for minimizing routing disruption caused by IP link failures. We develop a probabilistically correlated failure (PCF) model to quantify the impact of IP link failure on the reliability of backup paths. With the PCF model, we propose an algorithm to choose multiple reliable backup paths to protect each IP link. When an IP link fails, its traffic is split onto multiple backup paths to ensure that the rerouted traffic load on each IP link does not exceed the usable bandwidth. We evaluate our approach using real ISP networks with both optical and IP layer topologies. Experimental results show that two backup paths are adequate for protecting a logical link. Compared with existing works, the backup paths selected by our approach are at least 18 percent more reliable and the routing disruption is reduced by at least 22 percent. Unlike prior works, the proposed approach prevents the rerouted traffic from interfering with normal traffic.
C1 [Zheng, Qiang] Penn State Univ, Dept Comp Sci & Engn, University Pk, PA 16802 USA.
[Cao, Guohong] Penn State Univ, Dept Comp Sci, University Pk, PA 16802 USA.
[La Porta, Thomas F.] Penn State Univ, EIC, University Pk, PA 16802 USA.
[Swami, Ananthram] Army Res Lab, Adelphi, MA USA.
RP Zheng, Q (reprint author), Penn State Univ, Dept Comp Sci & Engn, University Pk, PA 16802 USA.
NR 38
TC 1
Z9 2
U1 0
U2 3
PU IEEE COMPUTER SOC
PI LOS ALAMITOS
PA 10662 LOS VAQUEROS CIRCLE, PO BOX 3014, LOS ALAMITOS, CA 90720-1314 USA
SN 1045-9219
EI 1558-2183
J9 IEEE T PARALL DISTR
JI IEEE Trans. Parallel Distrib. Syst.
PD JUL
PY 2014
VL 25
IS 7
BP 1659
EP 1669
DI 10.1109/TPDS.2013.157
PG 11
WC Computer Science, Theory & Methods; Engineering, Electrical & Electronic
SC Computer Science; Engineering
GA AN0NX
UT WOS:000340282400001
ER
PT J
AU Fazel, K
Scharffenberg, WA
Bombardelli, FA
AF Fazel, Khalida
Scharffenberg, William A.
Bombardelli, Fabian A.
TI Assessment of the Melt Rate Function in a Temperature Index Snow Model
Using Observed Data
SO JOURNAL OF HYDROLOGIC ENGINEERING
LA English
DT Article
DE Melt rate; Snowmelt modeling; Hydrologic Engineering Center's hydrologic
modeling system (HEC-HMS); Error propagation; Antecedent temperature
index-melt rate (ATIMR); Antecedent temperature index; Streamflow
synthesis and reservoir regulation (SSARR) model; American River
Watershed; Rainfall-runoff modeling; Snow water equivalent
AB Temperature index snowmelt models often require representation of a snowpack's melt rate. Defining the melt rate as a function of an accumulated number of warming degree-days is achieved in some temperature index models through the antecedent temperature index-melt rate (ATIMR) function, and provides a reasonable method for adjusting the melt rate during the season. Modelers have typically relied on a default ATIMR function developed two decades ago. However, literature concerning the nature of this default function and how it was developed is largely nonexistent. This paper presents results of a comparison between the default ATIMR function and ATIMR functions computed from field data from two headwater stations within the American River watershed upstream of Folsom Lake, California. An error analysis was also performed using the site-specific data. Using the Hydrologic Engineering Center's hydrologic modeling system (HEC-HMS), it was found that modeled results often varied dramatically between the default curve and the computed curves. In one case, modeled results showed significant improvement between the default method and that of the data-derived approach. This finding suggests that conventional use of the default 1991 curve, often employed in practice irrespective of season and/or location, should at the very least be reconsidered. (C) 2014 American Society of Civil Engineers.
C1 [Fazel, Khalida] GEI Consultants Inc, Rancho Cordova, CA 95670 USA.
[Fazel, Khalida; Bombardelli, Fabian A.] Univ Calif Davis, Dept Civil & Environm Engn, Davis, CA 95616 USA.
[Scharffenberg, William A.] US Army, Corps Engineers, Hydrol Engn Ctr, Davis, CA 95616 USA.
RP Scharffenberg, WA (reprint author), US Army, Corps Engineers, Hydrol Engn Ctr, 609 Second St, Davis, CA 95616 USA.
EM kfazel@geiconsultants.com; wscharffenberg@gmail.com;
fabombardelli@ucdavis.edu
NR 8
TC 0
Z9 0
U1 2
U2 14
PU ASCE-AMER SOC CIVIL ENGINEERS
PI RESTON
PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA
SN 1084-0699
EI 1943-5584
J9 J HYDROL ENG
JI J. Hydrol. Eng.
PD JUL
PY 2014
VL 19
IS 7
BP 1275
EP 1282
DI 10.1061/(ASCE)HE.1943-5584.0000925
PG 8
WC Engineering, Civil; Environmental Sciences; Water Resources
SC Engineering; Environmental Sciences & Ecology; Water Resources
GA AM8XW
UT WOS:000340163600001
ER
PT J
AU Singh, VP
Byrd, A
Cui, HJ
AF Singh, Vijay P.
Byrd, Aaron
Cui, Huijuan
TI Flow Duration Curve Using Entropy Theory
SO JOURNAL OF HYDROLOGIC ENGINEERING
LA English
DT Article
DE Duration curves; Flow duration curve; Lagrange multipliers; Principle of
maximum entropy; Shannon entropy
AB Using the entropy theory, this study derives a function for modeling the flow duration curve (FDC) based on two equations that form simple constraints: (1) the total probability of all flow discharges, and (2) the mean discharge. Parameters of the derived curve are determined from the entropy theory with the use of these two constraints. For deriving the flow duration curve by the entropy theory, a nonlinear cumulative distribution function is assumed, which is tested using observed flow data. The derived flow duration curves are tested using field data and are found to be in agreement with observed curves. With the entropy parameter determined for each station, the flow duration curve can also be forecasted for different recurrence intervals. The main advantage of the use of the entropy theory-based FDCs is that the parameters are based on observations, and hence no fitting is needed. Second, the theory permits a probabilistic characterization of the flow duration curve and hence the probability density function underlying the curve. It also permits a quantitative assessment of the uncertainty of the flow duration curve. Additional work is needed to regionalize the FDC parameters. (C) 2014 American Society of Civil Engineers.
C1 [Singh, Vijay P.] Texas A&M Univ, Dept Biol & Agr Engn, Dept Civil & Environm Engn, College Stn, TX 77843 USA.
[Byrd, Aaron] US Army, Corps Engineers, Hydrol Syst Branch, Coastal & Hydraul Lab,Engineer Res Dev Ctr, Vicksburg, MS 39181 USA.
[Cui, Huijuan] Texas A&M Univ, Water Management & Hydrol Sci Program, College Stn, TX 77843 USA.
RP Cui, HJ (reprint author), Texas A&M Univ, Water Management & Hydrol Sci Program, College Stn, TX 77843 USA.
EM cui.huijuan@gmail.com
NR 17
TC 2
Z9 2
U1 0
U2 7
PU ASCE-AMER SOC CIVIL ENGINEERS
PI RESTON
PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA
SN 1084-0699
EI 1943-5584
J9 J HYDROL ENG
JI J. Hydrol. Eng.
PD JUL
PY 2014
VL 19
IS 7
BP 1340
EP 1348
DI 10.1061/(ASCE)HE.1943-5584.0000930
PG 9
WC Engineering, Civil; Environmental Sciences; Water Resources
SC Engineering; Environmental Sciences & Ecology; Water Resources
GA AM8XW
UT WOS:000340163600007
ER
PT J
AU Schultz, MK
Wright, LKM
Furtado, MD
Stone, MF
Moffett, MC
Kelley, NR
Bourne, AR
Lumeh, WZ
Schultz, CR
Schwartz, JE
Lumley, LA
AF Schultz, M. K.
Wright, L. K. M.
Furtado, M. de Araujo
Stone, M. F.
Moffett, M. C.
Kelley, N. R.
Bourne, A. R.
Lumeh, W. Z.
Schultz, C. R.
Schwartz, J. E.
Lumley, L. A.
TI Caramiphen edisylate as adjunct to standard therapy attenuates
soman-induced seizures and cognitive deficits in rats
SO NEUROTOXICOLOGY AND TERATOLOGY
LA English
DT Article
DE Soman; Caramiphen; Anticonvulsant; Behavior; Chemical warfare nerve
agents; Rats
ID HIPPOCAMPAL PYRAMIDAL NEURONS; AGENT-INDUCED SEIZURE; SIGMA-SITE
LIGANDS; ANTICHOLINERGIC DRUGS; BASOLATERAL AMYGDALA; MECHANISMS;
HYPOTHERMIA; EFFICACY; NEUROPATHOLOGY; PRETREATMENT
AB The progression of epileptiform activity following soman (GD) exposure is characterized by a period of excessive cholinergic activity followed by excessive glutamatergic activity resulting in status epilepticus, which may lead to neuropathological damage and behavioral deficits. Caramiphen edisylate is an anticholinergic drug with antiglutamatergic properties, which conceptually may be a beneficial therapeutic approach to the treatment of nerve agent exposure. In the present study, rats were exposed to 1.2 LD50 GD or saline, treated with atropine sulfate (2 mg/kg, im) and HI-6 (93.6 mg/kg, im) 1 min after GD exposure, and monitored for seizure activity. Rats were treated with diazepam (10 mg/kg, sc) and caramiphen (0, 20 or 100 mg/kg, im) 30 min after seizure onset. Following GD exposure, performance was evaluated using a battery of behavioral tests to assess motor coordination and function, sensorimotor gating, and cognitive function. Caramiphen as adjunct to diazepam treatment attenuated GD-induced seizure activity, neuropathological damage, and cognitive deficits compared to diazepam alone, but did not attenuate the GD-induced sensorimotor gating impairment. These findings show that physiological, behavioral, and neuropathological effects of GD exposure can be attenuated by treatment with caramiphen as an adjunct to therapy, even if administration is delayed to 30 min after seizure onset. Published by Elsevier Inc.
C1 [Schultz, M. K.; Wright, L. K. M.; Stone, M. F.; Moffett, M. C.; Kelley, N. R.; Bourne, A. R.; Lumeh, W. Z.; Schultz, C. R.; Schwartz, J. E.; Lumley, L. A.] US Army, Med Res Inst Chem Def, Aberdeen Proving Ground, MD 21010 USA.
[Furtado, M. de Araujo] Walter Reed Army Inst Res, Silver Spring, MD 20910 USA.
RP Lumley, LA (reprint author), US Army, Med Res Inst Chem Def, 3100 Ricketts Point Rd, Aberdeen Proving Ground, MD 21010 USA.
EM lucille.a.lange.civ@mail.mil
FU Medical S&T Division & Physical Science Division
[CBM.NEURO.01.10.RC.007]; Defense Threat Reduction Agency-Jiont Science
and Technology Office
FX This research was supported by the Defense Threat Reduction Agency-Jiont
Science and Technology Office, Medical S&T Division & Physical Science
Division (PI: Dr. Lucille Lumley, grant #: CBM.NEURO.01.10.RC.007). Dr.
Linnzi Wright, Mark Schultz, Caroline Schultz and Andrew Bourne were
supported by appointments to the Student/Postdoctoral Research
Participation Program at the U.S. Army Medical Research Institute of
Chemical Defense administered by the Oak Ridge Institute for Science and
Education through an interagency appointment between the U.S. Department
of Energy and USAMRMC.
NR 54
TC 2
Z9 2
U1 1
U2 10
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0892-0362
EI 1872-9738
J9 NEUROTOXICOL TERATOL
JI Neurotoxicol. Teratol.
PD JUL-AUG
PY 2014
VL 44
BP 89
EP 104
DI 10.1016/j.ntt.2014.06.002
PG 16
WC Neurosciences; Toxicology
SC Neurosciences & Neurology; Toxicology
GA AN0VL
UT WOS:000340302000010
PM 24946037
ER
PT J
AU Boylan, GL
Cho, BR
AF Boylan, Gregory L.
Cho, Byung Rae
TI Solving the Multidisciplinary Robust Parameter Design Problem for Mixed
Type Quality Characteristics under Asymmetric Conditions
SO QUALITY AND RELIABILITY ENGINEERING INTERNATIONAL
LA English
DT Article
DE quality; multidisciplinary robust parameter design; mixed quality
characteristics; goal programming; skew normal distribution
ID RESPONSE-SURFACE OPTIMIZATION; PROCESS CAPABILITY; OPTIMUM PROCESS;
DISTRIBUTIONS; MODEL; SPECIFICATIONS; RELIABILITY; PRECISION; FRAMEWORK;
TAGUCHI
AB Quality practitioners often identify robust parameter design (RPD) as one of the most important and effective methods for process and quality improvement. Within this framework, identifying the optimal factor settings that achieve desired process targets with minimum variance is critical and can translate to significant reductions in product waste and processing costs. In solving this problem, most traditional RPD models consider only a single quality characteristic of interest. However, products are often judged by multiple quality characteristics, which often have conflicting objectives. Conventional RPD models that address the multi-response problem typically only examine like-type cases, and those that consider mixed types of quality characteristics often overlook any asymmetry that is likely to exist in certain types. In contrast, this article proposes a multidisciplinary RPD methodology that provides an enhanced approach for modeling multiple, mixed type quality characteristics; uses the skew normal distribution to allow for a fuller and more accurate representation of asymmetric system properties and to facilitate simultaneous modeling of both symmetric and asymmetric conditions; and implements a priority-based optimization scheme that affords engineers' and decision makers' flexibility in establishing and modifying optimization priorities. A numerical example is used to demonstrate the proposed methodology, and the results are compared traditional approaches to illustrate potential improvements. Copyright (c) 2013 John Wiley & Sons, Ltd.
C1 [Boylan, Gregory L.] US Mil Acad, Dept Syst Engn, West Point, NY 10996 USA.
[Cho, Byung Rae] Clemson Univ, Dept Ind Engn, Adv Qual Engn Lab, Clemson, SC 29634 USA.
RP Boylan, GL (reprint author), US Mil Acad, Dept Syst Engn, West Point, NY 10996 USA.
EM boylangc@earthlink.net
NR 61
TC 1
Z9 1
U1 1
U2 6
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0748-8017
EI 1099-1638
J9 QUAL RELIAB ENG INT
JI Qual. Reliab. Eng. Int.
PD JUL
PY 2014
VL 30
IS 5
BP 681
EP 695
DI 10.1002/qre.1520
PG 15
WC Engineering, Multidisciplinary; Engineering, Industrial; Operations
Research & Management Science
SC Engineering; Operations Research & Management Science
GA AN0OW
UT WOS:000340284900008
ER
PT J
AU Fox, GA
Felice, RG
Midgley, TL
Wilson, GV
Al-Madhhachi, AST
AF Fox, Garey A.
Felice, Rachel G.
Midgley, Taber L.
Wilson, Glenn V.
Al-Madhhachi, Abdul-Sahib T.
TI Laboratory soil piping and internal erosion experiments: evaluation of a
soil piping model for low-compacted soils
SO EARTH SURFACE PROCESSES AND LANDFORMS
LA English
DT Article
DE groundwater seepage; internal erosion; jet erosion test; piping; soil
erodibility
ID SEEPAGE EROSION; ERODIBILITY; SEDIMENT; PIPEFLOW; PREDICTION; STABILITY;
FAILURE; SCOUR; TESTS; FLOW
AB Mechanistic models have been proposed for soil piping and internal erosion on well-compacted levees and dams, but limited research has evaluated these models in less compacted (more erodible) soils typical of hillslopes and streambanks. This study utilized a soil box (50 cm long, 50 cm wide and 20 cm tall) to conduct constant-head, soil pipe and internal erosion experiments for two soils (clay loam from Dry Creek and sandy loam from Cow Creek streambanks) packed at uniform bulk densities. Initial gravimetric moisture contents prior to packing were 10, 12 and 14% for Dry Creek soil and 8, 12, and 14% for Cow Creek soil. A 1-cm diameter rod was placed horizontally along the length of the soil bed during packing and carefully removed after packing to create a continuous soil pipe. A constant head was maintained at the inflow end. Flow rates and sediment concentrations were measured from the pipe outlet. Replicate submerged jet erosion tests (JETs) were conducted to derive erodibility parameters for repacked samples at the same moisture contents. Flow rates from the box experiments were used to calibrate the mechanistic model. The influence of the initial moisture content was apparent, with some pipes (8% moisture content) expanding so fast that limited data was collected. The mechanistic model was able to estimate equivalent flow rates to those observed in the experiments, but had difficulty matching observed sediment concentrations when the pipes rapidly expanded. The JETs predicted similar erodibility coefficients compared to the mechanistic model for the more erodible cases but not for the less erodible cases (14% moisture content). Improved models are needed that better define the changing soil pipe cross-section during supply-and transport-limited internal erosion, especially for piping through lower compacted (more erodible) soils as opposed to more well-compacted soils resulting from constructing levees and dams. Copyright (C) 2013 John Wiley & Sons, Ltd.
C1 [Fox, Garey A.; Felice, Rachel G.] Oklahoma State Univ, Stillwater, OK 74078 USA.
[Felice, Rachel G.] US Army Corps Engineers, Tulsa, OK USA.
[Midgley, Taber L.] Civil & Environm Consultants Inc, Raynham, MA USA.
[Wilson, Glenn V.] ARS, USDA, Natl Sedimentat Lab, Oxford, MS USA.
[Al-Madhhachi, Abdul-Sahib T.] Al Mustansiriya Univ, Coll Engn, Dept Environm Engn, Baghdad, Iraq.
RP Fox, GA (reprint author), Oklahoma State Univ, 120 Agr Hall, Stillwater, OK 74078 USA.
EM garey.fox@okstate.edu
FU National Science Foundation (NSF) [0943491]; NSF
FX This material is based upon work supported by the National Science
Foundation (NSF) under Grant No. 0943491 and a NSF Graduate Research
Fellowship. Any opinions, findings, and conclusions or recommendations
expressed in this material are those of the authors and do not
necessarily reflect the views of the NSF. The authors acknowledge Mr
David Criswell and Mrs Kelsey Criswell for performing soil
characterization tests.
NR 37
TC 1
Z9 1
U1 4
U2 35
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0197-9337
EI 1096-9837
J9 EARTH SURF PROC LAND
JI Earth Surf. Process. Landf.
PD JUL
PY 2014
VL 39
IS 9
BP 1137
EP 1145
DI 10.1002/esp.3508
PG 9
WC Geography, Physical; Geosciences, Multidisciplinary
SC Physical Geography; Geology
GA AL9BW
UT WOS:000339435600001
ER
PT J
AU Goldman, SB
AF Goldman, Sarah B.
TI Avoiding common statistical pitfalls
SO JOURNAL OF HAND THERAPY
LA English
DT Editorial Material
C1 US Army Med Res & Mat Command, Ft Detrick, MD 21702 USA.
RP Goldman, SB (reprint author), US Army Med Res & Mat Command, Ft Detrick, MD 21702 USA.
EM sarah.b.goldman.mil@mail.mil
NR 2
TC 0
Z9 0
U1 0
U2 0
PU HANLEY & BELFUS-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0894-1130
EI 1545-004X
J9 J HAND THER
JI J. Hand Ther.
PD JUL-SEP
PY 2014
VL 27
IS 3
BP 163
EP 164
DI 10.1016/j.jht.2013.09.004
PG 2
WC Orthopedics; Rehabilitation; Surgery
SC Orthopedics; Rehabilitation; Surgery
GA AM3VI
UT WOS:000339780500001
PM 24100057
ER
PT J
AU Yalamanchili, C
Manda, VK
Chittiboyina, AG
HarrellJr, WA
Webb, RP
Khan, IA
AF Yalamanchili, C.
Manda, V. K.
Chittiboyina, A. G.
HarrellJr, W. A.
Webb, R. P.
Khan, I. A.
TI Identification of novel phytochemical inhibitors of botulinum neurotoxin
A
SO PLANTA MEDICA
LA English
DT Meeting Abstract
CT 55th Annual Meeting of the American-Society-of-Pharmacognosy (ASP)
CY AUG 02-06, 2014
CL Oxford, MS
SP Amer Soc Pharmacognosy
C1 [Yalamanchili, C.; Manda, V. K.; Chittiboyina, A. G.; Khan, I. A.] Univ Mississippi, Pharmaceut Sci Res Inst, Natl Ctr Nat Prod Res, University, MS 38677 USA.
[Yalamanchili, C.; Khan, I. A.] Univ Mississippi, Sch Pharm, Dept Pharmacognosy, University, MS 38677 USA.
[HarrellJr, W. A.; Webb, R. P.] US Army Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA.
[Khan, I. A.] King Saud Univ, Coll Pharm, Dept Pharmacognosy, Riyadh, Saudi Arabia.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0032-0943
EI 1439-0221
J9 PLANTA MED
JI Planta Med.
PD JUL
PY 2014
VL 80
IS 10
MA PH13
BP 821
EP 821
PG 1
WC Plant Sciences; Chemistry, Medicinal; Integrative & Complementary
Medicine; Pharmacology & Pharmacy
SC Plant Sciences; Pharmacology & Pharmacy; Integrative & Complementary
Medicine
GA AM3VP
UT WOS:000339781200332
ER
PT J
AU Alam, R
Lightcap, IV
Karwacki, CJ
Kamat, PV
AF Alam, Rabeka
Lightcap, Ian V.
Karwacki, Christopher J.
Kamat, Prashant V.
TI Sense and Shoot: Simultaneous Detection and Degradation of Low-Level
Contaminants Using Graphene-Based Smart Material Assembly
SO ACS NANO
LA English
DT Article
DE graphene oxide; photocatalysis; SERS detection; environmental
remediation; nitro compounds; TiO2
ID OXIDE; NANOPARTICLES; EXPLOSIVES; FLUORESCENCE; METALS; RDX; TNT
AB Smart material nanoassemblies that can simultaneously sense and shoot low-level contaminants from air and water are important for overcoming the threat of hazardous chemicals. Graphene oxide (GO) sheets deposited on mesoscopic TiO2 films that underpin the deposition of Ag nanoparticles with UV irradiation provide the foundation for the design of a smart material. The Ag particle size Is readily controlled through precursor concentration and UV irradiation time. These semiconductor graphene oxide-metal (SGM) films are SERS-active and hence capable of sensing aromatic contaminants such as 4-nitrobenzenethiol (4-NBT) in nanomolar range. Increased local concentration of organic molecules achieved through interaction with 2-D carbon support (GO) facilitates low-level detection of contaminants. Upon UV irradiation of 4-NBT-loaded SGM film, one can induce photocatalytic transformations. Thus, each component of the SGM film plays a pivotal role in aiding the detection and degradation of a contaminant dispersed in aqueous solutions. The advantage of using SGM films as multipurpose "detect and destroy" systems for nitroaromatic molecules is discussed.
C1 [Alam, Rabeka; Lightcap, Ian V.; Kamat, Prashant V.] Univ Notre Dame, Radiat Lab, Notre Dame, IN 46556 USA.
[Kamat, Prashant V.] Univ Notre Dame, Dept Chem & Biochem, Notre Dame, IN 46556 USA.
[Lightcap, Ian V.] Univ Notre Dame, Ctr Sustainable Energy Notre Dame, Notre Dame, IN 46556 USA.
[Karwacki, Christopher J.] US Army Res Dev & Engn Command, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA.
RP Kamat, PV (reprint author), Univ Notre Dame, Radiat Lab, Notre Dame, IN 46556 USA.
EM pkamat@nd.edu
FU Army Research Office [ARO 64011-CH]; Division of Chemical Sciences,
Geosciences, and Biosciences, Office of Basic Energy Sciences of the
U.S. Department of Energy [DE-FC02-04ER15533]
FX The research described in this paper is supported by the Army Research
Office through the award ARO 64011-CH. This is a document number 5022
from the Notre Dame Radiation Laboratory, which is supported by the
Division of Chemical Sciences, Geosciences, and Biosciences, Office of
Basic Energy Sciences of the U.S. Department of Energy through award
DE-FC02-04ER15533.
NR 34
TC 16
Z9 16
U1 21
U2 167
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 1936-0851
EI 1936-086X
J9 ACS NANO
JI ACS Nano
PD JUL
PY 2014
VL 8
IS 7
BP 7272
EP 7278
DI 10.1021/nn502336x
PG 7
WC Chemistry, Multidisciplinary; Chemistry, Physical; Nanoscience &
Nanotechnology; Materials Science, Multidisciplinary
SC Chemistry; Science & Technology - Other Topics; Materials Science
GA AL9LR
UT WOS:000339463100084
PM 24893206
ER
PT J
AU DeGregorio, BA
Chiavacci, SJ
Weatherhead, PJ
Willson, JD
Benson, TJ
Sperry, JH
AF DeGregorio, Brett A.
Chiavacci, Scott J.
Weatherhead, Patrick J.
Willson, John D.
Benson, Thomas J.
Sperry, Jinelle H.
TI Snake predation on North American bird nests: culprits, patterns and
future directions
SO JOURNAL OF AVIAN BIOLOGY
LA English
DT Review
ID BLACK RAT SNAKES; SONGBIRD NESTS; HABITAT USE; REPRODUCTIVE SUCCESS;
VIDEO IDENTIFICATION; SEASONAL-VARIATION; PREY INTERACTIONS;
ELAPHE-OBSOLETA; GRASSLAND BIRDS; MOVEMENTS
AB Predation is the leading cause of nest failure for most birds. Thus, for ornithologists interested in the causes and consequences of variation in nest success, knowing the identity and understanding the behavior of dominant nest predators is likely to be important. Video documentation of nests has shown that snakes are frequent predators. Here we reviewed 53 North American studies that used nest cameras and used these data to identify broad patterns in snake predation. Snakes accounted for 26% (range: 0-90%) of recorded predation events, with values exceeding 35% in a third of studies. Snakes were more frequent nest predators at lower latitudes and less frequent in forested habitat relative to other nest predators. Although 12 species of snakes have been identified as nest predators, ratsnakes Elaphe obsoleta, corn snakes E. guttata and fox snakes E. vulpina were the most frequent, accounting for >70% of all recorded nest predation events by snakes and have been documented preying on nests in 30-65% of studies conducted within their geographic ranges. Endotherm-specialist snakes (Elaphe and Pituophis genera) were more likely to depredate nests in forests and the canopy relative to other snakes, due to their affinity for edge habitat. Predation by only ratsnakes and corn snakes was predominantly nocturnal and only ratsnakes were more likely to prey on nests during the nestling stage. Snakes were not identified to species in over 30% of predation events, underlining the need for more complete reporting of results. A review of research to date suggests the best approach to investigating factors that bring snakes and nests into contact involves combining nesting studies with radio tracking of locally important snake nest predators.
C1 [DeGregorio, Brett A.; Chiavacci, Scott J.; Weatherhead, Patrick J.; Benson, Thomas J.; Sperry, Jinelle H.] Univ Illinois, Dept Nat Resources & Environm Sci, Champaign Urbana, IL 61801 USA.
[Chiavacci, Scott J.; Benson, Thomas J.] Univ Illinois, Prairie Res Inst, Illinois Nat Hist Survey, Champaign Urbana, IL 61820 USA.
[Sperry, Jinelle H.] Engineer Res & Dev Ctr, Champaign, IL 61822 USA.
[Willson, John D.] Univ Arkansas, Dept Biol Sci, Fayetteville, AR 72701 USA.
RP DeGregorio, BA (reprint author), Univ Illinois, Dept Nat Resources & Environm Sci, Champaign Urbana, IL 61801 USA.
EM badegregorio@gmail.com
FU Construction Engineering Research Laboratory of the Engineer Research
Development Center
FX Funding was provided by the Construction Engineering Research Laboratory
of the Engineer Research Development Center. We thank Tim Hayden for
assistance arranging funding. Phil Vogrinc and Valerie Buxton provided
feedback on early drafts. Numerous technicians provided assistance with
nest monitoring in Illinois and South Carolina. We wish to thank all the
authors who generously shared unreported data with us to facilitate this
review. Special thanks to the two reviewers who provided extremely
thorough and thoughtful comments, which improved the manuscript
significantly. All field work was conducted under South Carolina Dept of
Natural Resources permit no. G-11-03 and 23-2012A. Animal procedures
conformed to permits approved by the Univ. of Illinois (IACUC no. 11054
and no. 10127) and Univ. of Georgia (AUP no. A2011 04-007-Y2-A0).
NR 56
TC 11
Z9 11
U1 7
U2 62
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0908-8857
EI 1600-048X
J9 J AVIAN BIOL
JI J. Avian Biol.
PD JUL
PY 2014
VL 45
IS 4
BP 325
EP 333
DI 10.1111/jav.00364
PG 9
WC Ornithology
SC Zoology
GA AL9TV
UT WOS:000339485600003
ER
PT J
AU Be, NA
Allen, JE
Brown, TS
Gardner, SN
McLoughlin, KS
Forsberg, JA
Kirkup, BC
Chromy, BA
Luciw, PA
Elster, EA
Jaing, CJ
AF Be, Nicholas A.
Allen, Jonathan E.
Brown, Trevor S.
Gardner, Shea N.
McLoughlin, Kevin S.
Forsberg, Jonathan A.
Kirkup, Benjamin C.
Chromy, Brett A.
Luciw, Paul A.
Elster, Eric A.
Jaing, Crystal J.
TI Microbial Profiling of Combat Wound Infection through Detection
Microarray and Next-Generation Sequencing
SO JOURNAL OF CLINICAL MICROBIOLOGY
LA English
DT Article
ID IRAQI-FREEDOM; ACINETOBACTER; EXPRESSION; MANAGEMENT; INJURIES;
COLONIZATION; BIOMARKERS; CYTOKINE; BIOFILM; CARE
AB Combat wound healing and resolution are highly affected by the resident microbial flora. We therefore sought to achieve comprehensive detection of microbial populations in wounds using novel genomic technologies and bioinformatics analyses. We employed a microarray capable of detecting all sequenced pathogens for interrogation of 124 wound samples from extremity injuries in combat-injured U. S. service members. A subset of samples was also processed via next-generation sequencing and metagenomic analysis. Array analysis detected microbial targets in 51% of all wound samples, with Acinetobacter baumannii being the most frequently detected species. Multiple Pseudomonas species were also detected in tissue biopsy specimens. Detection of the Acinetobacter plasmid pRAY correlated significantly with wound failure, while detection of enteric-associated bacteria was associated significantly with successful healing. Whole-genome sequencing revealed broad microbial biodiversity between samples. The total wound bioburden did not associate significantly with wound outcome, although temporal shifts were observed over the course of treatment. Given that standard microbiological methods do not detect the full range of microbes in each wound, these data emphasize the importance of supplementation with molecular techniques for thorough characterization of wound-associated microbes. Future application of genomic protocols for assessing microbial content could allow application of specialized care through early and rapid identification and management of critical patterns in wound bioburden.
C1 [Be, Nicholas A.; Jaing, Crystal J.] Lawrence Livermore Natl Lab, Phys & Life Sci Directorate, Livermore, CA 94550 USA.
[Allen, Jonathan E.; Gardner, Shea N.; McLoughlin, Kevin S.] Lawrence Livermore Natl Lab, Computat Global Secur Directorates, Livermore, CA USA.
[Brown, Trevor S.; Forsberg, Jonathan A.; Elster, Eric A.] Naval Med Res Ctr, Regenerat Med Dept, Silver Spring, MD USA.
[Brown, Trevor S.; Forsberg, Jonathan A.; Elster, Eric A.] Uniformed Serv Univ Hlth Sci, Surg Crit Care Initiat, Bethesda, MD 20814 USA.
[Kirkup, Benjamin C.; Elster, Eric A.] Uniformed Serv Univ Hlth Sci, Norman M Rich Dept Surg, F Edward Hebert Sch Med, Bethesda, MD 20814 USA.
[Kirkup, Benjamin C.] Walter Reed Army Inst Res, Dept Wound Infect, Silver Spring, MD USA.
[Chromy, Brett A.; Luciw, Paul A.] Univ Calif Davis, Sch Med, Dept Pathol & Lab Med, Davis, CA 95616 USA.
[Luciw, Paul A.] Univ Calif Davis, Ctr Comparat Med, Davis, CA 95616 USA.
RP Be, NA (reprint author), Lawrence Livermore Natl Lab, Phys & Life Sci Directorate, Livermore, CA 94550 USA.
EM be1@llnl.gov; jaing2@llnl.gov
RI Kirkup, Benjamin/C-3610-2009; Brown, Trevor/F-7392-2015
OI Kirkup, Benjamin/0000-0002-8722-6218; Brown, Trevor/0000-0001-7042-785X
FU U.S. Army Medical Research and Materiel Command [MIPR1EO89M1115]; U. S.
Navy Bureau of Medicine and Surgery under the Medical Development
Program and Office of Naval Research [604771N. 0933.001. A0604]; U. S.
Department of Energy by Lawrence Livermore National Laboratory
[DE-AC52-07NA27344]; U. S. Government
FX This work was sponsored by the U.S. Army Medical Research and Materiel
Command (MIPR1EO89M1115). The U. S. Army Medical Research Acquisition
Activity (Fort Detrick, MD) is the awarding and administering
acquisition office. A portion of this effort was also supported by the
U. S. Navy Bureau of Medicine and Surgery under the Medical Development
Program and Office of Naval Research work unit (604771N. 0933.001.
A0604). This study was performed under the auspices of the U. S.
Department of Energy by Lawrence Livermore National Laboratory under
contract DE-AC52-07NA27344.; This document was prepared as an account of
work sponsored by an agency of the U. S. Government. Neither the U. S.
Government nor Lawrence Livermore National Security, LLC, nor any of
their employees makes any warranty, expressed or implied, or assumes any
legal liability or responsibility for the accuracy, completeness, or
usefulness of any information, apparatus, product, or process disclosed
or represents that its use would not infringe privately owned rights.
Reference herein to any specific commercial product, process, or service
by trade name, trademark, manufacturer, or otherwise does not
necessarily constitute or imply its endorsement, recommendation, or
favoring by the U. S. Government or Lawrence Livermore National
Security, LLC. The views and opinions of authors expressed herein do not
necessarily state or reflect those of the U. S. Government or Lawrence
Livermore National Security, LLC, and shall not be used for advertising
or product endorsement purposes.
NR 43
TC 10
Z9 11
U1 4
U2 14
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0095-1137
EI 1098-660X
J9 J CLIN MICROBIOL
JI J. Clin. Microbiol.
PD JUL
PY 2014
VL 52
IS 7
BP 2583
EP 2594
DI 10.1128/JCM.00556-14
PG 12
WC Microbiology
SC Microbiology
GA AL6YM
UT WOS:000339279700043
PM 24829242
ER
PT J
AU Houston, JR
Dean, RG
AF Houston, J. R.
Dean, R. G.
TI Shoreline Change on the East Coast of Florida
SO JOURNAL OF COASTAL RESEARCH
LA English
DT Article
DE Coastal erosion; coastal accretion; sea level rise
ID SEA-LEVEL RISE; SEDIMENT TRANSPORT; BRUUN RULE; SHOREFACE; EVOLUTION;
EROSION; USA
AB A shoreline change data base for Florida dating back to the mid-1800s is unique in the United States, and perhaps the world, with thousands of shoreline change measurements at a nominal spacing of 300 m. Moreover, data are available on factors contributing to shoreline change, including beach nourishment, disposal of dredged sand outside the littoral zone, cutting of new inlets and subsequent growth of ebb shoals, and longshore sediment transport into and along the east coast of Florida. Effects of relative sea level rise can be estimated using the Bruun Rule. These factors should have caused significant shoreline recession since the mid-1800s, but instead, the east coast of Florida has experienced significant average shoreline advance. The formation of carbonate sand is shown not to account for this difference. Onshore transport of sand from beyond closure depth, probably during episodic storm events, is the only possible source of the large quantity of sand that has advanced on average the shoreline of Florida's east coast. For shorelines with significant offshore deposits of sand, it is possible that sea level rise in conjunction with wave action contributes to onshore transport and shoreline accretion.
C1 [Houston, J. R.] US Army, Corps Engineers, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA.
[Dean, R. G.] Univ Florida, Dept Civil & Coastal Engn, Gainesville, FL 32611 USA.
RP Houston, JR (reprint author), US Army, Corps Engineers, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA.
EM james.r.houston@usace.army.mil
NR 59
TC 10
Z9 10
U1 0
U2 36
PU COASTAL EDUCATION & RESEARCH FOUNDATION
PI LAWRENCE
PA 810 EAST 10TH STREET, LAWRENCE, KS 66044 USA
SN 0749-0208
EI 1551-5036
J9 J COASTAL RES
JI J. Coast. Res.
PD JUL
PY 2014
VL 30
IS 4
BP 647
EP 660
DI 10.2112/JCOASTRES-D-14-00028.1
PG 14
WC Environmental Sciences; Geography, Physical; Geosciences,
Multidisciplinary
SC Environmental Sciences & Ecology; Physical Geography; Geology
GA AL8CZ
UT WOS:000339366800001
ER
PT J
AU Radomski, MV
Brininger, TL
AF Radomski, Mary Vining
Brininger, Teresa L.
TI Occupational Therapy for Servicemember and Veteran Recovery, Resilience,
and Reintegration: Opportunities for Societal Contribution and
Professional Transformation
SO AMERICAN JOURNAL OF OCCUPATIONAL THERAPY
LA English
DT Editorial Material
DE combat disorders; military personnel; occupational therapy; veterans
ID TRAUMATIC BRAIN-INJURY; POSTTRAUMATIC-STRESS-DISORDER; OPERATION
ENDURING FREEDOM; RECONSTRUCTION AIDES; IRAQI FREEDOM; PERFORMANCE;
MILITARY
C1 [Radomski, Mary Vining] Courage Kenny Res Ctr, Minneapolis, MN 55407 USA.
[Brininger, Teresa L.] US Army, War Coll, Carlisle, PA USA.
RP Radomski, MV (reprint author), Courage Kenny Res Ctr, 800 East 28th St & Chicago 12212, Minneapolis, MN 55407 USA.
EM Mary.Radomski@allina.com; Teresa.Brininger@us.army.mil
NR 16
TC 2
Z9 2
U1 1
U2 10
PU AMER OCCUPATIONAL THERAPY ASSOC, INC
PI BETHESDA
PA 4720 MONTGOMERY LANE, BETHESDA, MD 20814-3425 USA
SN 0272-9490
EI 1943-7676
J9 AM J OCCUP THER
JI Am. J. Occup. Ther.
PD JUL-AUG
PY 2014
VL 68
IS 4
BP 379
EP 380
DI 10.5014/ajot.2014.013060
PG 2
WC Rehabilitation
SC Rehabilitation
GA AL4FR
UT WOS:000339088800001
PM 25005499
ER
PT J
AU Smith, LB
Radomski, MV
Davidson, LF
Finkelstein, M
Weightman, MM
McCulloch, KL
Scherer, MR
AF Smith, Laurel B.
Radomski, Mary Vining
Davidson, Leslie Freeman
Finkelstein, Marsha
Weightman, Margaret M.
McCulloch, Karen L.
Scherer, Matthew R.
TI Development and Preliminary Reliability of a Multitasking Assessment for
Executive Functioning After Concussion
SO AMERICAN JOURNAL OF OCCUPATIONAL THERAPY
LA English
DT Article
DE brain concussion; executive function; military personnel;
reproducibility of results; task performance and analysis
ID TRAUMATIC BRAIN-INJURY; ECOLOGICAL VALIDITY; EVERYDAY LIFE; PERFORMANCE;
VERSION; PEOPLE; SAMPLE; DAMAGE
AB OBJECTIVES. Executive functioning deficits may result from concussion. The Charge of Quarters (CQ) Duty Task is a multitask assessment designed to assess executive functioning in servicemembers after concussion. In this article, we discuss the rationale and process used in the development of the CQ Duty Task and present pilot data from the preliminary evaluation of interrater reliability (IRR).
METHOD. Three evaluators observed as 12 healthy participants performed the CQ Duty Task and measured performance using various metrics. Intraclass correlation coefficient (ICC) quantified IRR.
RESULTS. The ICC for task completion was .94. ICCs for other assessment metrics were variable.
CONCLUSION. Preliminary IRR data for the CQ Duty Task are encouraging, but further investigation is needed to improve IRR in some domains. Lessons learned in the development of the CQ Duty Task could benefit future test development efforts with populations other than the military.
C1 [Smith, Laurel B.] US Army, Environm Med Res Inst, Natick, MA 01760 USA.
[Radomski, Mary Vining; Finkelstein, Marsha; Weightman, Margaret M.] Courage Kenny Res Ctr, Minneapolis, MN USA.
[Davidson, Leslie Freeman] Shenandoah Univ, Winchester, VA USA.
[McCulloch, Karen L.] Univ N Carolina, Div Phys Therapy, Chapel Hill, NC USA.
[Scherer, Matthew R.] Andrew Rader US Army Hlth Clin, Ft Myer, VA USA.
RP Smith, LB (reprint author), US Army, Environm Med Res Inst, 15 Kansas St, Natick, MA 01760 USA.
EM laurel.b.smith.mil@mail.mil
NR 22
TC 3
Z9 3
U1 1
U2 3
PU AMER OCCUPATIONAL THERAPY ASSOC, INC
PI BETHESDA
PA 4720 MONTGOMERY LANE, BETHESDA, MD 20814-3425 USA
SN 0272-9490
EI 1943-7676
J9 AM J OCCUP THER
JI Am. J. Occup. Ther.
PD JUL-AUG
PY 2014
VL 68
IS 4
BP 439
EP 443
DI 10.5014/ajot.2014.012393
PG 5
WC Rehabilitation
SC Rehabilitation
GA AL4FR
UT WOS:000339088800009
PM 25005507
ER
PT J
AU Pidcoke, HF
Baer, LA
Wu, XW
Wolf, SE
Aden, JK
Wade, CE
AF Pidcoke, Heather F.
Baer, Lisa A.
Wu, Xiaowu
Wolf, Steven E.
Aden, James K.
Wade, Charles E.
TI Insulin effects on glucose tolerance, hypermetabolic response, and
circadian-metabolic protein expression in a rat burn and disuse model
SO AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE
PHYSIOLOGY
LA English
DT Article
DE insulin; glucose tolerance; hypermetabolism; circadian rhythm; burn and
disuse
ID CRITICALLY-ILL PATIENTS; ACUTE-PHASE RESPONSE; SKELETAL-MUSCLE;
GROWTH-HORMONE; INJURED PATIENTS; THERMAL-INJURY; RECEPTOR SUBSTRATE-1;
EXOGENOUS INSULIN; STRESS-RESPONSE; CATABOLISM
AB Insulin controls hyperglycemia after severe burns, and its use opposes the hypermetabolic response. The underlying molecular mechanisms are poorly understood, and previous research in this area has been limited because of the inadequacy of animal models to mimic the physiological effects seen in humans with burns. Using a recently published rat model that combines both burn and disuse components, we compare the effects of insulin treatment vs. vehicle on glucose tolerance, hypermetabolic response, muscle loss, and circadian-metabolic protein expression after burns. Male Sprague-Dawley rats were assigned to three groups: cage controls (n = 6); vehicle-treated burn and hindlimb unloading (VBH; n = 11), and insulin-treated burn and hindlimb unloading (IBH; n = 9). With the exception of cage controls, rats underwent a 40% total body surface area burn with hindlimb unloading, then IBH rats received 12 days of subcutaneous insulin injections (5 units.kg(-1) . day(-1)), and VBH rats received an equivalent dose of vehicle. Glucose tolerance testing was performed on day 14, after which blood and tissues were collected for analysis. Body mass loss was attenuated by insulin treatment (VBH = 265 +/- 17 g vs. IBH = 283 +/- 14 g, P = 0.016), and glucose clearance capacity was increased. Soleus and gastrocnemius muscle loss was decreased in the IBH group. Insulin receptor substrate-1, AKT, FOXO-1, caspase-3, and PER1 phosphorylation was altered by injury and disuse, with levels restored by insulin treatment in almost all cases. Insulin treatment after burn and during disuse attenuated the hypermetabolic response, increased glucose clearance, and normalized circadian-metabolic protein expression patterns. Therapies aimed at targeting downstream effectors may provide the beneficial effects of insulin without hypoglycemic risk.
C1 [Pidcoke, Heather F.; Wu, Xiaowu; Aden, James K.] US Army, Inst Surg Res, Ft Sam Houston, TX 78234 USA.
[Baer, Lisa A.; Wade, Charles E.] Univ Texas Hlth Sci Ctr Houston, Houston, TX 77030 USA.
[Wolf, Steven E.] Univ Texas SW Med Ctr Dallas, Dallas, TX 75390 USA.
RP Wade, CE (reprint author), Univ Texas Hlth Sci Ctr Houston, Ctr Translat Injury Res, 6431 Fannin St,MSB 5-204, Houston, TX 77030 USA.
EM Charles.E.Wade@uth.tmc.edu
FU NCATS NIH HHS [UL1 TR000371]; NIGMS NIH HHS [1R01GM063120]
NR 74
TC 6
Z9 6
U1 0
U2 1
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0363-6119
EI 1522-1490
J9 AM J PHYSIOL-REG I
JI Am. J. Physiol.-Regul. Integr. Comp. Physiol.
PD JUL 1
PY 2014
VL 307
IS 1
BP R1
EP R10
DI 10.1152/ajpregu.00312.2013
PG 10
WC Physiology
SC Physiology
GA AL1YG
UT WOS:000338921900001
PM 24760998
ER
PT J
AU Jennissen, CA
Harland, KK
Wetjen, K
Peck, J
Hoogerwerf, P
Denning, GM
AF Jennissen, Charles A.
Harland, Karisa K.
Wetjen, Kristel
Peck, Jeffrey
Hoogerwerf, Pam
Denning, Gerene M.
TI A School-Based Study of Adolescent All-Terrain Vehicle Exposure, Safety
Behaviors, and Crash Experience
SO ANNALS OF FAMILY MEDICINE
LA English
DT Article
DE all-terrain vehicle; injury prevention; adolescent behavior; rural;
safety; helmet; prevention & control; accidents
ID INJURY-PREVENTION; UNITED-STATES; ANTICIPATORY GUIDANCE; USE PATTERNS;
CHILDREN; YOUTH; ATV; MORTALITY; KNOWLEDGE; DRIVERS
AB PURPOSE More youth are killed every year in the United States in all-terrain vehicle (ATV) crashes than on bicycles, and since 2001, one-fifth of all ATV fatalities have involved victims aged 15 years or younger. Effectively preventing pediatric ATV-related deaths and injuries requires knowledge about youth riding practices. Our objective was to examine ATV use, crash prevalence, and riding behaviors among adolescent students in a rural state.
METHODS We administered a cross-sectional survey to 4,684 youths aged 11 to 16 years at 30 schools across Iowa from November 2010 to April 2013. Descriptive and comparative analyses were performed.
RESULTS Regardless of rurality, at least 75% of students reported having been on an ATV, with 38% of those riding daily or weekly. Among ATV riders, 57% had been in a crash. Most riders engaged in risky behaviors, including riding with passengers (92%), on public roads (81%), or without a helmet (64%). Almost 60% reported engaging in all 3 behaviors; only 2% engaged in none. Multivariable modeling revealed male youth, students riding daily/weekly, and those reporting both riding on public roads and with passengers were 1.61 (95% CI, 1.36-1.91), 3.73 (95% CI, 3.10-4.50), and 3.24 (95% CI, 2.09-5.04) times more likely to report a crash, respectively.
CONCLUSIONS Three-fourths of youths surveyed were exposed to ATVs. The majority of riders had engaged in unsafe behaviors and experienced a crash. Given this widespread use and the potentially considerable morbidity of pediatric ATV crashes, prevention efforts, including anticipatory guidance by primary care clinicians serving families at risk, should be a higher priority.
C1 [Jennissen, Charles A.; Harland, Karisa K.; Denning, Gerene M.] Univ Iowa, Carver Coll Med, Dept Emergency Med, Iowa City, IA 52242 USA.
[Jennissen, Charles A.; Wetjen, Kristel; Hoogerwerf, Pam] Univ Iowa, Childrens Hosp, Iowa City, IA 52242 USA.
[Harland, Karisa K.] Univ Iowa Injury Prevent Res, Iowa City, IA USA.
[Wetjen, Kristel] Univ Iowa Hosp & Clin, Div Pediat Surg, Iowa City, IA 52242 USA.
[Peck, Jeffrey] US Army, Corps Engineers, Washington, DC 20310 USA.
RP Jennissen, CA (reprint author), Univ Iowa, Carver Coll Med, Dept Emergency Med, 200 Hawkins Dr, Iowa City, IA 52242 USA.
EM charles-jennissen@uiowa.edu
FU Kohl's Cares; program of Kohl's
FX Support for this study was provided by a grant to the University of Iowa
Children's Hospital from Kohl's Cares, a program of Kohl's that supports
kids' health and education initiatives nationwide.
NR 38
TC 8
Z9 8
U1 0
U2 10
PU ANNALS FAMILY MEDICINE
PI LEAWOOD
PA 11400 TOMAHAWK CREEK PARKWAY, LEAWOOD, KS 66211-2672 USA
SN 1544-1709
EI 1544-1717
J9 ANN FAM MED
JI Ann. Fam. Med.
PD JUL-AUG
PY 2014
VL 12
IS 4
BP 310
EP 316
DI 10.1370/afm.1663
PG 7
WC Primary Health Care; Medicine, General & Internal
SC General & Internal Medicine
GA AL6XF
UT WOS:000339276300006
PM 25024238
ER
PT J
AU Pasiakos, SM
Margolis, LM
McClung, JP
Cao, JJ
Whigham, LD
Combs, GF
Young, AJ
AF Pasiakos, S. M.
Margolis, L. M.
McClung, J. P.
Cao, J. J.
Whigham, L. D.
Combs, G. F.
Young, A. J.
TI Whole-body protein turnover response to short-term high-protein diets
during weight loss: a randomized controlled trial
SO INTERNATIONAL JOURNAL OF OBESITY
LA English
DT Article
DE weight loss; protein turnover; net balance; leucine oxidation
ID LEUCINE METABOLISM; NITROGEN-BALANCE; ENERGY DEFICIT; EXERCISE; WOMEN;
MEN; CARBOHYDRATE; HUMANS; OBESE; MASS
AB To determine whole-body protein turnover responses to high-protein diets during weight loss, 39 adults (age, 21+/-1 years; VO2peak, 48+/-1 ml kg(-1) min(-1); body mass index, 25+/-1 kg m(2)) were randomized to diets providing protein at the recommend dietary allowance (RDA), 2 x -RDA or 3 x -RDA. A 10-day weight maintenance period preceded a 21-day, 40% energy deficit. Postabsorptive (FASTED) and postprandial (FED) whole-body protein turnover was determined during weight maintenance (day 10) and energy deficit (day 31) using [1-C-13] leucine. FASTED flux, synthesis and breakdown were lower (P<0.05) for energy deficit than weight maintenance. Protein flux and synthesis were higher (P<0.05) for FED than FASTED. Feeding attenuated (P<0.05) breakdown during weight maintenance but not energy deficit. Oxidation increased (P<0.05) between dietary protein levels and feeding stimulated oxidation, although oxidative responses to feeding were higher (P<0.05) for energy deficit than weight maintenance. FASTED net balance decreased between dietary protein levels, but in the FED state, net balance was lower for 3 x -RDA as compared with RDA and 2 x -RDA (diet-by-state, P<0.05). Consuming dietary protein at levels above the RDA, particularly 3 x -RDA, during short-term weight loss increases protein oxidation with concomitant reductions in net protein balance.
C1 [Pasiakos, S. M.; Margolis, L. M.; McClung, J. P.; Young, A. J.] US Army, Environm Med Res Inst, Mil Nutr Div, Natick, MA 01760 USA.
[Cao, J. J.; Whigham, L. D.; Combs, G. F.] USDA ARS, Grand Forks Human Nutr Res Ctr, Grand Forks, ND 58202 USA.
RP Pasiakos, SM (reprint author), US Army, Environm Med Res Inst, Mil Nutr Div, Kansas St,Bldg 42, Natick, MA 01760 USA.
EM stefan.pasiakos@us.army.mil
RI Pasiakos, Stefan/E-6295-2014;
OI Pasiakos, Stefan/0000-0002-5378-5820; , Lee/0000-0002-0652-1304;
Whigham, Leah/0000-0002-5376-8967
FU US Army Medical Research and Material Command; US Department of
Agriculture, Agricultural Research Service [58-1950-7707]
FX This work was supported by the US Army Medical Research and Material
Command and the US Department of Agriculture, Agricultural Research
Service, under agreement no. 58-1950-7707.
NR 34
TC 7
Z9 7
U1 0
U2 12
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0307-0565
EI 1476-5497
J9 INT J OBESITY
JI Int. J. Obes.
PD JUL
PY 2014
VL 38
IS 7
BP 1015
EP 1018
DI 10.1038/ijo.2013.197
PG 4
WC Endocrinology & Metabolism; Nutrition & Dietetics
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA AL5TU
UT WOS:000339197000020
PM 24166063
ER
PT J
AU Johnson, BD
van Helmond, N
Curry, TB
van Buskirk, CM
Convertino, VA
Joyner, MJ
AF Johnson, Blair D.
van Helmond, Noud
Curry, Timothy B.
van Buskirk, Camille M.
Convertino, Victor A.
Joyner, Michael J.
TI Reductions in central venous pressure by lower body negative pressure or
blood loss elicit similar hemodynamic responses
SO JOURNAL OF APPLIED PHYSIOLOGY
LA English
DT Article
DE hemorrhage; central hypovolemia; heart rate; blood pressure; stroke
volume
ID ARTERIAL PULSE PRESSURE; CENTRAL HYPOVOLEMIA; STROKE VOLUME; VASOPRESSIN
RELEASE; HEMORRHAGIC-SHOCK; TRAUMA DEATHS; HUMANS; TOLERANCE; MODEL;
EPIDEMIOLOGY
AB The purpose of this study was to compare hemodynamic and blood analyte responses to reduced central venous pressure (CVP) and pulse pressure (PP) elicited during graded lower body negative pressure (LBNP) to those observed during graded blood loss (BL) in conscious humans. We hypothesized that the stimulus-response relationships of CVP and PP to hemodynamic responses during LBNP would mimic those observed during BL. We assessed CVP, PP, heart rate, mean arterial pressure (MAP), and other hemodynamic markers in 12 men during LBNP and BL. Blood samples were obtained for analysis of catecholamines, hematocrit, hemoglobin, arginine vasopressin, and blood gases. LBNP consisted of 5-min stages at 0, 15, 30, and 45 mmHg of suction. BL consisted of 5 min at baseline and following three stages of 333 ml of hemorrhage (1,000 ml total). Individual r(2) values and linear regression slopes were calculated to determine whether the stimulus (CVP and PP)-hemodynamic response trajectories were similar between protocols. The CVP-MAP trajectory was the only CVP-response slope that was statistically different during LBNP compared with BL (0.93 +/- 0.27 vs. 0.13 +/- 0.26; P = 0.037). The PP-heart rate trajectory was the only PP-response slope that was statistically different during LBNP compared with BL (-1.85 +/- 0.45 vs. -0.46 +/- 0.27; P = 0.024). Norepinephrine, hematocrit, and hemoglobin were all lower at termination in the BL protocol compared with LBNP (P < 0.05). Consistent with our hypothesis, LBNP mimics the hemodynamic stimulus-response trajectories observed during BL across a significant range of CVP in humans.
C1 [Johnson, Blair D.; van Helmond, Noud; Curry, Timothy B.; Joyner, Michael J.] Mayo Clin, Dept Anesthesiol, Rochester, MN USA.
[van Helmond, Noud] Radboud Univ Nijmegen, Med Ctr, Dept Physiol, NL-6525 ED Nijmegen, Netherlands.
[van Buskirk, Camille M.] Mayo Clin, Dept Lab Med & Pathol, Rochester, MN USA.
[Convertino, Victor A.] US Army Inst Surg Res, Ft Sam Houston, TX USA.
RP Joyner, MJ (reprint author), 200 First St SW, Rochester, MN 55905 USA.
EM Joyner.Michael@mayo.edu
FU U.S. Army MRMC Combat Casualty Care Research Program [W81XWH-11-1-0823];
American Heart Association Midwest Affiliate Grant [13POST-14380027];
Dutch Heart Foundation [2012SB013]
FX Support for this study was provided by U.S. Army MRMC Combat Casualty
Care Research Program Grant W81XWH-11-1-0823, American Heart Association
Midwest Affiliate Grant 13POST-14380027 to B.D.J., and by Dutch Heart
Foundation E. Dekker Stipend 2012SB013 to N.V.H.
NR 38
TC 18
Z9 18
U1 0
U2 3
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 8750-7587
EI 1522-1601
J9 J APPL PHYSIOL
JI J. Appl. Physiol.
PD JUL
PY 2014
VL 117
IS 2
BP 131
EP 141
DI 10.1152/japplphysiol.00070.2014
PG 11
WC Physiology; Sport Sciences
SC Physiology; Sport Sciences
GA AL5JM
UT WOS:000339169800005
PM 24876357
ER
PT J
AU Trexler, ST
Lundy, JB
Chung, KK
Nitzschke, SL
Burns, CJ
Shields, BA
Cancio, LC
AF Trexler, Scott T.
Lundy, Jonathan B.
Chung, Kevin K.
Nitzschke, Stephanie L.
Burns, Christopher J.
Shields, Beth A.
Cancio, Leopoldo C.
TI Prevalence and Impact of Late Defecation in the Critically Ill,
Thermally Injured Adult Patient
SO JOURNAL OF BURN CARE & RESEARCH
LA English
DT Article
ID RESTING ENERGY-EXPENDITURE; LATE PARENTERAL-NUTRITION; ENTERAL
NUTRITION; CARE PATIENTS; FAILURE; ASPEN
AB The aim of this study was to determine the prevalence of late defecation (absence of laxation for more than 6 days after admission) as an indicator of lower-gastrointestinal (GI) tract dysfunction in burn patients. In addition, the authors wanted to determine whether the addition of polyethylene glycol 3350 to the standard bowel regimen led to improvement in markers of lower-GI function and outcomes. The authors conducted a retrospective chart review of patients admitted to the burn intensive care unit during a 26-month period. Inclusion criteria were 20% or more TBSA burn, requirement for mechanical ventilation, and age over 18 years. Of 83 patients included, the prevalence of late defecation was 36.1% (n = 30). There was no association between late defecation and mortality. Patients with late defecation had more frequent episodes of constipation after first defecation (P = .03), of feeding intolerance (P = .007), and received total parenteral nutrition more frequently (P = .005). The addition of polyethylene glycol to the standard bowel regimen did not affect markers of lower-GI function. Late defecation occurs in more than one third of critically ill burn patients. Late defecation was associated with ongoing lower-GI dysfunction, feeding intolerance, and the use of total parenteral nutrition. The causal relationship between these problems has not been determined. A prospective study at the authors' institution is currently planned to attempt to validate late defecation as a marker of lower-GI tract dysfunction, determine its relationship to various outcomes, and determine risk factors for its development.
C1 [Trexler, Scott T.] San Antonio Mil Med Ctr, Dept Trauma & Acute Care Surg, Ft Sam Houston, TX USA.
[Lundy, Jonathan B.; Chung, Kevin K.; Nitzschke, Stephanie L.; Burns, Christopher J.; Shields, Beth A.; Cancio, Leopoldo C.] US Army, Inst Surg Res, Ft Sam Houston, TX 78234 USA.
RP Lundy, JB (reprint author), US Army, Inst Surg Res, 3698 Chambers Pass, Ft Sam Houston, TX 78234 USA.
NR 18
TC 6
Z9 6
U1 1
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1559-047X
EI 1559-0488
J9 J BURN CARE RES
JI J. Burn Care Res.
PD JUL-AUG
PY 2014
VL 35
IS 4
BP E224
EP E229
DI 10.1097/BCR.0b013e31829b0057
PG 6
WC Emergency Medicine; Dermatology; Surgery
SC Emergency Medicine; Dermatology; Surgery
GA AL0WM
UT WOS:000338847800005
PM 23877139
ER
PT J
AU Dorsey, KL
Bedair, SS
Fedder, GK
AF Dorsey, K. L.
Bedair, S. S.
Fedder, G. K.
TI Gas chemical sensitivity of a CMOS MEMS cantilever functionalized via
evaporation driven assembly
SO JOURNAL OF MICROMECHANICS AND MICROENGINEERING
LA English
DT Article
DE resonant chemical sensor; microelectromechanical systems; evaporation
driven assembly; gravimetric; CMOS MEMS
ID SENSORS
AB This work demonstrates an electrostatically actuated resonant microcantilever fabricated in a complementary metal oxide semiconductor process and functionalized with a chemically sorbent polymer layer for the detection of volatile organic compounds. Deposition of the chemically sorbent layer is controlled through evaporation-driven assembly. Analytical and finite element analysis models of the deposited polymer layer on the microcantilever resonant frequency and mass sensitivity are presented. Fabrication of the chemical sensor, including a description of polymer deposition through evaporation-driven assembly within a capillary, is detailed. The completely functionalized resonator demonstrates a limit of detection of 1.6 ppm for toluene. An optimal polymer sensitive layer deposition of 42% of the total beam length is measured from frequency instability and sensitivity tests.
C1 [Dorsey, K. L.] Univ Calif Berkeley, Dept Elect Engn & Comp Sci, Berkeley, CA 94720 USA.
[Bedair, S. S.] US Army, Res Lab, Sensors & Elect Devices Directorate, Adelphi, MD USA.
[Fedder, G. K.] Carnegie Mellon Univ, Dept Elect & Comp Engn, Pittsburgh, PA 15213 USA.
[Fedder, G. K.] Carnegie Mellon Univ, Inst Complex Engn Syst, Pittsburgh, PA 15213 USA.
RP Dorsey, KL (reprint author), Univ Calif Berkeley, Dept Elect Engn & Comp Sci, Berkeley, CA 94720 USA.
EM KLDorsey@berkeley.edu
NR 20
TC 4
Z9 4
U1 2
U2 26
PU IOP PUBLISHING LTD
PI BRISTOL
PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND
SN 0960-1317
EI 1361-6439
J9 J MICROMECH MICROENG
JI J. Micromech. Microeng.
PD JUL
PY 2014
VL 24
IS 7
AR 075001
DI 10.1088/0960-1317/24/7/075001
PG 8
WC Engineering, Electrical & Electronic; Nanoscience & Nanotechnology;
Instruments & Instrumentation; Physics, Applied
SC Engineering; Science & Technology - Other Topics; Instruments &
Instrumentation; Physics
GA AL1XC
UT WOS:000338918600001
ER
PT J
AU Malachowski, K
Jamal, M
Jin, QR
Polat, B
Morris, CJ
Gracias, DH
AF Malachowski, Kate
Jamal, Mustapha
Jin, Qianru
Polat, Beril
Morris, Christopher J.
Gracias, David H.
TI Self-Folding Single Cell Grippers
SO NANO LETTERS
LA English
DT Article
DE Self-assembly; origami; lab-on-a-chip; surgery; nanomedicine;
nanomechanics; robotics
ID FLOW-CONTROL CONCEPT; SILICON MONOXIDE; THIN-FILMS; HETEROGENEITY;
FABRICATION; CULTURE; CANCER; STRESS; MANIPULATION; DYNAMICS
AB Given the heterogeneous nature of cultures, tumors, and tissues, the ability to capture, contain, and analyze single cells is important for genomics, proteomics, diagnostics, therapeutics, and surgery. Moreover, for surgical applications in small conduits in the body such as in the cardiovascular system, there is a need for tiny tools that approach the size of the single red blood cells that traverse the blood vessels and capillaries. We describe the fabrication of arrayed or untethered single cell grippers composed of biocompatible and bioresorbable silicon monoxide and silicon dioxide. The energy required to actuate these grippers is derived from the release of residual stress in 3-27 nm thick films, did not require any wires, tethers, or batteries, and resulted in folding angles over 100 degrees with folding radii as small as 765 nm. We developed and applied a finite element model to predict these folding angles. Finally, we demonstrated the capture of live mouse fibroblast cells in an array of grippers and individual red blood cells in untethered grippers which could be released from the substrate to illustrate the potential utility for in vivo operations.
C1 [Malachowski, Kate; Jamal, Mustapha; Jin, Qianru; Polat, Beril; Gracias, David H.] Johns Hopkins Univ, Dept Chem & Biomol Engn, Baltimore, MD 21218 USA.
[Morris, Christopher J.] US Army Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA.
RP Gracias, DH (reprint author), Johns Hopkins Univ, Dept Chem & Biomol Engn, 3400 N Charles St, Baltimore, MD 21218 USA.
EM dgracias@jhu.edu
OI Gracias, David/0000-0003-2735-4725
FU NIH [1DP2OD004346]; National Science Foundation [CBET-1066898,
CMMI-1200241]; Army Research Laboratory; Northrop Grumman
FX This research was supported by NIH 1DP2OD004346 and the National Science
Foundation grants CBET-1066898 and CMMI-1200241, the Army Research
Laboratory, and Northrop Grumman. We thank Professor Benjamin Schaffer
for assistance with the modeling software.
NR 80
TC 18
Z9 18
U1 8
U2 65
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 1530-6984
EI 1530-6992
J9 NANO LETT
JI Nano Lett.
PD JUL
PY 2014
VL 14
IS 7
BP 4164
EP 4170
DI 10.1021/nl500136a
PG 7
WC Chemistry, Multidisciplinary; Chemistry, Physical; Nanoscience &
Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied;
Physics, Condensed Matter
SC Chemistry; Science & Technology - Other Topics; Materials Science;
Physics
GA AL2TZ
UT WOS:000338979700072
PM 24937214
ER
PT J
AU Gurton, KP
Yuffa, AJ
Videen, GW
AF Gurton, Kristan P.
Yuffa, Alex J.
Videen, Gorden W.
TI Enhanced facial recognition for thermal imagery using polarimetric
imaging
SO OPTICS LETTERS
LA English
DT Article
ID SURFACE-ROUGHNESS; POLARIZATION; EMISSION
AB We present a series of long-wave-infrared (LWIR) polarimetric-based thermal images of facial profiles in which polarization-state information of the image-forming radiance is retained and displayed. The resultant polarimetric images show enhanced facial features, additional texture, and details that are not present in corresponding conventional thermal imagery. It has been generally thought that conventional thermal imagery (MidIR or LWIR) could not produce the detailed spatial information required for reliable human identification due to the so-called "ghosting" effect often seen in thermal imagery of human subjects. By using polarimetric information, we are able to extract subtle surface features of the human face, thus improving subject identification. Polarimetric image sets considered include the conventional thermal intensity image, S0, the two Stokes images, S1 and S2, and a Stokes image product called the degree-of-linear-polarization image. (C) 2014 Optical Society of America
C1 [Gurton, Kristan P.; Yuffa, Alex J.; Videen, Gorden W.] US Army Res Lab, Computat & Informat Sci Directorate Adelphi, Adelphi, MD 20783 USA.
RP Gurton, KP (reprint author), US Army Res Lab, Computat & Informat Sci Directorate Adelphi, Adelphi, MD 20783 USA.
EM kristan.p.gurton.civ@mail.mil
RI Yuffa, Alex/B-5498-2014
OI Yuffa, Alex/0000-0002-3600-1131
FU U.S. Army Research Laboratory (ARL); [W911NF-12-2-0019]
FX This research was sponsored by the U.S. Army Research Laboratory (ARL)
and was accomplished under Cooperative Agreement Number
W911NF-12-2-0019. The views and conclusions contained in this document
are those of the authors and should not be interpreted as representing
the official policies, either expressed or implied, of the ARL or the
U.S. government. The U.S. government is authorized to reproduce and
distribute reprints for government purposes, notwithstanding any
copyright notation herein.
NR 11
TC 12
Z9 13
U1 0
U2 3
PU OPTICAL SOC AMER
PI WASHINGTON
PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA
SN 0146-9592
EI 1539-4794
J9 OPT LETT
JI Opt. Lett.
PD JUL 1
PY 2014
VL 39
IS 13
BP 3857
EP 3859
DI 10.1364/OL.39.003857
PG 3
WC Optics
SC Optics
GA AL2CJ
UT WOS:000338933200042
PM 24978755
ER
PT J
AU Xu, XJ
Tikuisis, P
AF Xu, Xiaojiang
Tikuisis, Peter
TI Thermoregulatory Modeling for Cold Stress
SO COMPREHENSIVE PHYSIOLOGY
LA English
DT Article
ID CONVECTIVE HEAT-TRANSFER; SKIN BLOOD-FLOW; AGED HUMAN SKIN; FEMALE
REPRODUCTIVE HORMONES; SURVIVAL-TIME PREDICTION; LOCAL THERMAL CONTROL;
X-RAY ABSORPTIOMETRY; HUMAN-BODY; INDUCED VASODILATION; WATER IMMERSION
AB Modeling for cold stress has generated a rich history of innovation, has exerted a catalytic influence on cold physiology research, and continues to impact human activity in cold environments. This overview begins with a brief summation of cold thermoregulatory model development followed by key principles that will continue to guide current and future model development. Different representations of the human body are discussed relative to the level of detail and prediction accuracy required. In addition to predictions of shivering and vasomotor responses to cold exposure, algorithms are presented for thermoregulatory mechanisms. Various avenues of heat exchange between the human body and a cold environment are reviewed. Applications of cold thermoregulatory modeling range from investigative interpretation of physiological observations to forecasting skin freezing times and hypothermia survival times. While these advances have been remarkable, the future of cold stress modeling is still faced with significant challenges that are summarized at the end of this overview. Published 2014.
C1 [Xu, Xiaojiang] US Army Res Inst Environm Med, Biophys & Biomed Modeling Div, Natick, MA 01760 USA.
[Tikuisis, Peter] Def R&D Canada, Sociocognit Syst Sect, Toronto, ON, Canada.
RP Xu, XJ (reprint author), US Army Res Inst Environm Med, Biophys & Biomed Modeling Div, Natick, MA 01760 USA.
EM xiaojiang.xu.civ@mail.mil
NR 241
TC 5
Z9 5
U1 2
U2 26
PU JOHN WILEY & SONS INC
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN, NJ 07030 USA
SN 2040-4603
J9 COMPR PHYSIOL
JI Compr. Physiol.
PD JUL
PY 2014
VL 4
IS 3
BP 1057
EP 1081
DI 10.1002/cphy.c130047
PG 25
WC Physiology
SC Physiology
GA AK9SC
UT WOS:000338766000005
PM 24944030
ER
PT J
AU Arrigo, KR
Perovich, DK
Pickart, RS
Brown, ZW
van Dijken, GL
Lowry, KE
Mills, MM
Palmer, MA
Balch, WM
Bates, NR
Benitez-Nelson, CR
Brownlee, E
Frey, KE
Laney, SR
Mathis, J
Matsuoka, A
Mitchell, BG
Moore, GWK
Reynolds, RA
Sosik, HM
Swift, JH
AF Arrigo, Kevin R.
Perovich, Donald K.
Pickart, Robert S.
Brown, Zachary W.
van Dijken, Gert L.
Lowry, Kate E.
Mills, Matthew M.
Palmer, Molly A.
Balch, William M.
Bates, Nicholas R.
Benitez-Nelson, Claudia R.
Brownlee, Emily
Frey, Karen E.
Laney, Samuel R.
Mathis, Jeremy
Matsuoka, Atsushi
Mitchell, B. Greg
Moore, G. W. K.
Reynolds, Rick A.
Sosik, Heidi M.
Swift, James H.
TI Phytoplankton blooms beneath the sea ice in the Chukchi sea
SO DEEP-SEA RESEARCH PART II-TOPICAL STUDIES IN OCEANOGRAPHY
LA English
DT Article
DE Arctic; Sea ice; Phytoplankton
ID MARINE MAMMALS; BERING STRAIT; ARCTIC-OCEAN; BARENTS SEA; ALGAL BLOOM;
FOOD WEBS; SUMMER; SHELF; FLOW; PHOTOSYNTHESIS
AB In the Arctic Ocean, phytoplankton blooms on continental shelves are often limited by light availability, and are therefore thought to be restricted to waters free of sea ice. During July 2011 in the Chukchi Sea, a large phytoplankton bloom was observed beneath fully consolidated pack ice and extended from the ice edge to > 100 km into the pack The bloom was composed primarily of diatoms, with biomass reaching 1291 mg chlorophyll alpha m(-2) and rates of carbon fixation as high as 3.7 g C m(-2) d(-1). Although the sea ice where the bloom was observed was near 100% concentration and 0.8-12 m thick, 30-40% of its surface was covered by melt ponds that transmitted 4-fold more light than adjacent areas of bare ice, providing sufficient light for phytoplankton to bloom. Phytoplankton growth rates associated with the under-ice bloom averaged 0.9 d(-1) and were as high as 1.6 d(-1). We argue that a thinning sea ice cover with more numerous melt ponds over the past decade has enhanced light penetration through the sea ice into the upper water column, favoring the development of these blooms. These observations, coupled with additional biogeochemical evidence, suggest that phytoplankton blooms are currently widespread on nutrient-rich Arctic continental shelves and that satellite-based estimates of annual primary production in waters where under-ice blooms develop are similar to 10-fold too low. These massive phytoplankton blooms represent a marked shift in our understanding of Arctic marine ecosystems. (C) 2014 Elsevier Ltd. All rights reserved.
C1 [Arrigo, Kevin R.; Brown, Zachary W.; van Dijken, Gert L.; Lowry, Kate E.; Mills, Matthew M.; Palmer, Molly A.] Stanford Univ, Dept Environm Earth Syst Sci, Stanford, CA 94305 USA.
[Perovich, Donald K.] Cold Reg Res & Engn Lab, Engineer Res & Dev Ctr, Hanover, NH 03755 USA.
[Perovich, Donald K.] Dartmouth Coll, Thayer Sch Engn, Hanover, NH 03755 USA.
[Pickart, Robert S.] Woods Hole Oceanog Inst, Dept Phys Oceanog, Woods Hole, MA 02543 USA.
[Balch, William M.] Bigelow Lab Ocean Sci, Harbor, ME 04575 USA.
[Bates, Nicholas R.] Bermuda Inst Ocean Sci, St Georges, Bermuda.
[Benitez-Nelson, Claudia R.] Univ S Carolina, Marine Sci Program, Columbia, SC 29208 USA.
[Benitez-Nelson, Claudia R.] Univ S Carolina, Dept Earth & Ocean Sci, Columbia, SC 29208 USA.
[Brownlee, Emily; Laney, Samuel R.; Sosik, Heidi M.] Woods Hole Oceanog Inst, Dept Biol, Woods Hole, MA 02543 USA.
[Frey, Karen E.] Clark Univ, Grad Sch Geog, Worcester, MA 01610 USA.
[Mathis, Jeremy] NOAA, Pacific Marine Environm Lab, Seattle, WA 98115 USA.
[Matsuoka, Atsushi] Univ Paris 06, Lab Oceanog Villefranche, F-06238 Villefranche Sur Mer, France.
[Matsuoka, Atsushi] Univ Laval, Dept Biol, Takuvik Joint Int Lab, Quebec City, PQ G1K 7P4, Canada.
[Matsuoka, Atsushi] Univ Laval, Quebec Ocean, Quebec City, PQ G1K 7P4, Canada.
[Mitchell, B. Greg; Reynolds, Rick A.; Swift, James H.] Univ Calif San Diego, Scripps Inst Oceanog, La Jolla, CA 92093 USA.
[Moore, G. W. K.] Univ Toronto, Dept Phys, Toronto, ON M5S 1A7, Canada.
RP Arrigo, KR (reprint author), Stanford Univ, Dept Environm Earth Syst Sci, 473 Via Ortega, Stanford, CA 94305 USA.
EM arrigo@stanford.edu
OI Benitez-Nelson, Claudia/0000-0002-1004-5048; Reynolds,
Rick/0000-0002-1579-3600; Lowry, Kate/0000-0002-1604-5428; Sosik,
Heidi/0000-0002-4591-2842
FU Ocean Biology and Biogeochemistry Program; Cryosphere Science Program of
the National Aeronautic and Space Administration [NNX10AF42G,
NNH10A017I, NNX10AT67G, NNX10AG36G, NNX09AE42G, NNX11AF65G, NNX10AH71G,
NNX10AGO7G, NNX10AG05G]
FX This research was supported by the Ocean Biology and Biogeochemistry
Program and the Cryosphere Science Program of the National Aeronautic
and Space Administration (NNX10AF42G to K. Arrigo, R. Pickart, and J.
Swift, NNH10A017I to D. Perovich, NNX10AT67G to W. Balch, NNX10AG36G to
N. Bates and J. Mathis, NNX09AE42G and NNX11AF65G to B. G. Mitchell and
C. Benitez-Nelson, NNX10AH71G to K. Frey, NNX10AGO7G to S. Laney and H.
Sosik, and NNX10AG05G to R. Reynolds) and by the Malina project. We
would like to thank the captain and crew of the USCGC Healy.
NR 91
TC 35
Z9 36
U1 11
U2 92
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0967-0645
EI 1879-0100
J9 DEEP-SEA RES PT II
JI Deep-Sea Res. Part II-Top. Stud. Oceanogr.
PD JUL
PY 2014
VL 105
BP 1
EP 16
DI 10.1016/j.dsr2.2014.03.018
PG 16
WC Oceanography
SC Oceanography
GA AL2TP
UT WOS:000338978700001
ER
PT J
AU Ter-Gabrielyan, N
Fromzel, V
Yan, Z
Han, X
Zhang, H
Wang, J
Dubinskii, M
AF Ter-Gabrielyan, N.
Fromzel, V.
Yan, Z.
Han, X.
Zhang, H.
Wang, J.
Dubinskii, M.
TI Highly efficient resonantly pumped Er3+:LuVO4 laser
SO OPTICAL MATERIALS EXPRESS
LA English
DT Article
ID CONTINUOUS-WAVE; ND-LUVO4 CRYSTAL; PERFORMANCE
AB Absorption and emission spectra of Er3+:LuVO4 for the I-4(15/2) <-> I-4(13/2) transitions have been investigated at room and cryogenic temperatures. A corrected energy level diagram was built. An efficient, resonantly pumped Er3+:LuVO4 laser operating at 1609 nm (pi-polarization) or 1597.5 nm (sigma-polarization) was demonstrated. For CW pumping into the 1532 nm absorption line by a narrow-bandwidth Er-fiber laser, the maximum output power was similar to 4.6 W and the maximum slope efficiency was 64% - the best reported efficiency of Er-doped vanadate lasers at room temperature. Resonant pumping into the 1529 nm absorption band with a fiber-coupled diode laser yielded a 62% slope efficiency. To the best of our knowledge, this is the first report on an Er:LuVO4 laser. (C) 2014 Optical Society of America
C1 [Ter-Gabrielyan, N.; Fromzel, V.; Dubinskii, M.] US Army Res Lab, Adelphi, MD 20783 USA.
[Yan, Z.; Zhang, H.; Wang, J.] Shandong Univ, State Key Lab Crystal Mat, Jinan 250100, Peoples R China.
[Han, X.] Lasence Inc, Qingdao 266107, Peoples R China.
RP Ter-Gabrielyan, N (reprint author), US Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA.
EM nikolay.e.ter-gabrielyan.civ@mail.mil
NR 10
TC 2
Z9 2
U1 1
U2 13
PU OPTICAL SOC AMER
PI WASHINGTON
PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA
SN 2159-3930
J9 OPT MATER EXPRESS
JI Opt. Mater. Express
PD JUL 1
PY 2014
VL 4
IS 7
BP 1355
EP 1360
DI 10.1364/OME.4.001355
PG 6
WC Materials Science, Multidisciplinary; Optics
SC Materials Science; Optics
GA AL1GZ
UT WOS:000338875100008
ER
PT J
AU Watanaveeradej, V
Gibbons, RV
Simasathien, S
Nisalak, A
Jarman, RG
Kerdpanich, A
Tournay, E
De La Barrerra, R
Dessy, F
Toussaint, JF
Eckels, KH
Thomas, SJ
Innis, BL
AF Watanaveeradej, Veerachai
Gibbons, Robert V.
Simasathien, Sriluck
Nisalak, Ananda
Jarman, Richard G.
Kerdpanich, Angkool
Tournay, Elodie
De La Barrerra, Rafael
Dessy, Francis
Toussaint, Jean-Francois
Eckels, Kenneth H.
Thomas, Stephen J.
Innis, Bruce L.
TI Safety and Immunogenicity of a Rederived, Live-Attenuated Dengue Virus
Vaccine in Healthy Adults Living in Thailand: A Randomized Trial
SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
LA English
DT Article
ID PHASE-I TRIAL; INFECTIONS; FORMULATIONS
AB Safety and immunogenicity of two formulations of a live-attenuated tetravalent dengue virus (TDEN) vaccine produced using rederived master seeds from a precursor vaccine were tested against a placebo control in a phase II, randomized, double blind trial (NCT00370682). Two doses were administered 6 months apart to 120 healthy, predominantly flavivirus-primed adults (87.5% and 97.5% in the two vaccine groups and 92.5% in the placebo group). Symptoms and signs reported after vaccination were mild to moderate and transient. There were no vaccine-related serious adverse events or dengue cases reported. Asymptomatic, low-level viremia (dengue virus type 2 [DENV-2], DENV-3, or DENV-4) was detected in 5 of 80 vaccine recipients. One placebo recipient developed a subclinical natural DENV-1 infection. All flavivirus-unprimed subjects and at least 97.1% of flavivirus-primed subjects were seropositive to antibodies against all four DENV types 1 and 3 months post-TDEN dose 2. The TDEN vaccine was immunogenic with an acceptable safety profile in flavivirus-primed adults.
C1 Phramongkutklao Hosp PMK, Dept Pediat, Bangkok, Thailand.
US Army Med Component Armed Forces Res, Inst Med Sci, Bangkok, Thailand.
[Thomas, Stephen J.] Walter Reed Army Inst Res, Viral Dis Branch, Silver Spring, MD 20910 USA.
GlaxoSmithKline Vaccines, Wavre, Belgium.
Walter Reed Army Inst Res, Translat Med Branch, Bioprod Facil, Silver Spring, MD 20910 USA.
GlaxoSmithKline Vaccines, King Of Prussia, PA USA.
RP Thomas, SJ (reprint author), Walter Reed Army Inst Res, Viral Dis Branch, 503 Robert Grant Ave, Silver Spring, MD 20910 USA.
EM stephen.j.thomas3.mil@mail.mil
FU US Army Medical Research and Materiel Command (Fort Detrick, MD);
GlaxoSmithKline Biologicals SA (Rixensart, Belgium)
FX This work was funded by US Army Medical Research and Materiel Command
(Fort Detrick, MD) and GlaxoSmithKline Biologicals SA (Rixensart,
Belgium) under a Cooperative Research and Development Agreement.
GlaxoSmithKline Biologicals SA was involved in all stages of study
conduct, including analysis of the data, and also took in all costs
associated with the development and publication of this manuscript.
NR 21
TC 9
Z9 10
U1 0
U2 1
PU AMER SOC TROP MED & HYGIENE
PI MCLEAN
PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA
SN 0002-9637
EI 1476-1645
J9 AM J TROP MED HYG
JI Am. J. Trop. Med. Hyg.
PD JUL
PY 2014
VL 91
IS 1
BP 119
EP 128
DI 10.4269/ajtmh.13-0452
PG 10
WC Public, Environmental & Occupational Health; Tropical Medicine
SC Public, Environmental & Occupational Health; Tropical Medicine
GA AK9MH
UT WOS:000338750700022
PM 24865677
ER
PT J
AU Ringelberg, DB
Cole, DM
Foley, KL
Ruidaz-Santiago, CM
Reynolds, CM
AF Ringelberg, D. B.
Cole, D. M.
Foley, K. L.
Ruidaz-Santiago, C. M.
Reynolds, C. M.
TI Compressive strength of soils amended with a bacterial succinoglycan:
effects of soluble salts and organic matter
SO CANADIAN GEOTECHNICAL JOURNAL
LA English
DT Article
DE biopolymer; mechanical behavior; soil; soluble salts; organic matter
ID AGGREGATION; FORCE
AB The ability to stabilize soils in a cost effective and efficient manner has utility in both civil and military applications. This study examines the ability of a bacterial succinoglycan to bind and strengthen the silt fractions of three geochemically different surface soils. Small-scale specimen preparation and uniaxial compression test methods were developed to observe effects of biopolymer concentration and silt surface condition on specimen stress-strain response. Results indicate that the biopolymer was effective at strengthening all three natural silts and when applied at concentrations of 1-15 mg.mL(-1), the increase in strength was linear. Silt surface condition was then modified by sequential removal of soluble salts and organic matter. For two of the silts, the removal of salts and organic matter had significant and cumulative negative effects on specimen compressive strength, deformation at peak stress, time to failure, and absorbed strain energy at failure. For a silt characterized by a high cation exchange capacity, high pH, and low aggregate percentage, the removal of organic matter did not reduce compressive strength beyond the level associated with the removal of soluble salts. Results from this study indicate that surface modification can significantly affect the compressive strength of silt materials and identified aggregate content as a principal determinant.
C1 [Ringelberg, D. B.; Cole, D. M.; Foley, K. L.; Reynolds, C. M.] US Army, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA.
[Ruidaz-Santiago, C. M.] Univ Puerto Rico, Dept Geol, Mayaguez, PR 00708 USA.
RP Ringelberg, DB (reprint author), US Army ERDC CRREL, 72 Lyme Rd, Hanover, NH 03755 USA.
EM david.b.ringelberg@usace.army.mil
NR 22
TC 1
Z9 1
U1 2
U2 11
PU CANADIAN SCIENCE PUBLISHING, NRC RESEARCH PRESS
PI OTTAWA
PA 65 AURIGA DR, SUITE 203, OTTAWA, ON K2E 7W6, CANADA
SN 0008-3674
EI 1208-6010
J9 CAN GEOTECH J
JI Can. Geotech. J.
PD JUL
PY 2014
VL 51
IS 7
BP 747
EP 757
DI 10.1139/cgj-2012-0369
PG 11
WC Engineering, Geological; Geosciences, Multidisciplinary
SC Engineering; Geology
GA AK8YV
UT WOS:000338715600003
ER
PT J
AU Hoedebecke, K
Hertug, M
AF Hoedebecke, Kyle
Hertug, Marinela
TI The Doctor and the Violin
SO FAMILY MEDICINE
LA English
DT Editorial Material
C1 [Hoedebecke, Kyle] Womack Army Med Ctr, Family Med Residency Clin, Ft Bragg, NC 28307 USA.
[Hertug, Marinela] Ormylia Hlth Ctr, Halkidiki, Greece.
RP Hoedebecke, K (reprint author), Womack Army Med Ctr, Family Med Residency Clin, Ft Bragg, NC 28307 USA.
EM kyle.l.hoedebecke.mil@mail.mil
NR 0
TC 0
Z9 0
U1 0
U2 0
PU SOC TEACHERS FAMILY MEDICINE
PI LEAWOOD
PA 11400 TOMAHAWK CREEK PARKWAY, STE 540, LEAWOOD, KS 66207 USA
SN 0742-3225
EI 1938-3800
J9 FAM MED
JI Fam. Med.
PD JUL-AUG
PY 2014
VL 46
IS 7
BP 554
EP 555
PG 2
WC Primary Health Care; Medicine, General & Internal
SC General & Internal Medicine
GA AL0NT
UT WOS:000338824300013
PM 25058553
ER
PT J
AU Harwood, JF
Farooq, M
Richardson, AG
Doud, CW
Putnam, JL
Szumlas, DE
Richardson, JH
AF Harwood, James F.
Farooq, Muhammad
Richardson, Alec G.
Doud, Carl W.
Putnam, John L.
Szumlas, Daniel E.
Richardson, Jason H.
TI Exploring New Thermal Fog and Ultra-Low Volume Technologies to Improve
Indoor Control of the Dengue Vector, Aedes aegypti (Diptera: Culicidae)
SO JOURNAL OF MEDICAL ENTOMOLOGY
LA English
DT Article
DE Aedes aegypti; ultra-low volume; thermal fog; indoor space spray;
pyriproxyfen
ID EMERGENCY CONTROL; ADULTICIDE EFFICACY; PYRIPROXYFEN; FORMULATION;
INSECTICIDE; THAILAND; LARVAE
AB Control of the mosquito vector, Aedes aegypti (L.), inside human habitations must be performed quickly and efficiently to reduce the risk of transmission during dengue outbreaks. As part of a broad study to assess the efficacy of dengue vector control tools for the U.S. Military, two pesticide delivery systems (ultra-low volume [ULV] and thermal fog) were evaluated for their ability to provide immediate control of Ae. aegypti mosquitoes with a contact insecticide inside simulated urban structures. An insect growth regulator was also applied to determine how well each sprayer delivered lethal doses of active ingredient to indoor water containers for pupal control. Mortality of caged Ae. aegypti, pesticide droplet size, and droplet deposition were recorded after applications. In addition, larval and pupal mortality was measured from treated water samples for 4 wk after the applications. The ULV and the thermal fogger performed equally well in delivering lethal doses of adulticide throughout the structures. The ULV resulted in greater larval mortality and adult emergence inhibition in the water containers for a longer period than the thermal fogger. Therefore, the ULV technology is expected to be a better tool for sustained vector suppression when combined with an effective insect growth regulator. However, during a dengue outbreak, either delivery system should provide an immediate knockdown of vector populations that may lower the risk of infection and allow other suppression strategies to be implemented.
C1 [Harwood, James F.; Farooq, Muhammad; Richardson, Alec G.; Doud, Carl W.] Navy Entomol Ctr Excellence, Naval Air Stn, Jacksonville, FL 32212 USA.
[Putnam, John L.] US Air Force Acad, HQ USAFA DFB, Dept Biol, Colorado Springs, CO 80840 USA.
[Szumlas, Daniel E.] Walter Reed Army Inst Res, Entomol Branch 503, Silver Spring, MD 20910 USA.
[Richardson, Jason H.] Armed Forces Pest Management Board, Silver Spring, MD 20910 USA.
RP Harwood, JF (reprint author), Navy Entomol Ctr Excellence, Naval Air Stn, Box 43,Bldg 937, Jacksonville, FL 32212 USA.
EM james.harwood@med.navy.mil
FU Deployed War Fighter Protection Program; Defense Medical Research and
Development Program
FX We thank J. Kerce, C. Waits, V. Smith, J. Anderson, M. McDonough, J.
Wright, M. Denson, R. Platt, L. Santana, J. Francona, and R. Oakes for
technical assistance during field and laboratory trials. Also, we thank
P. J. Obenauer, P. Nunn, and H. Arimoto for editorial assistance. This
research was funded by the Deployed War Fighter Protection Program and
the Defense Medical Research and Development Program.
NR 29
TC 4
Z9 5
U1 3
U2 13
PU ENTOMOLOGICAL SOC AMER
PI ANNAPOLIS
PA 3 PARK PLACE, STE 307, ANNAPOLIS, MD 21401-3722 USA
SN 0022-2585
EI 1938-2928
J9 J MED ENTOMOL
JI J. Med. Entomol.
PD JUL
PY 2014
VL 51
IS 4
BP 845
EP 854
DI 10.1603/ME14056
PG 10
WC Entomology; Veterinary Sciences
SC Entomology; Veterinary Sciences
GA AL0TW
UT WOS:000338840700016
PM 25118418
ER
PT J
AU McKellar, AE
Kesler, DC
Mitchell, RJ
Delaney, DK
Walters, JR
AF McKellar, Ann E.
Kesler, Dylan C.
Mitchell, Robert J.
Delaney, David K.
Walters, Jeffrey R.
TI Geographic variation in fitness and foraging habitat quality in an
endangered bird
SO BIOLOGICAL CONSERVATION
LA English
DT Article
DE Fitness; Fledgling production; Foraging habitat; Group size; Model;
Picoides borealis; Red-cockaded woodpecker
ID RED-COCKADED WOODPECKERS; POPULATION VIABILITY ANALYSIS; CONSERVATION
BIOLOGY; SPATIALLY EXPLICIT; SPOTTED OWL; MANAGEMENT; MODELS; FOREST;
NICHE; CLASSIFICATION
AB Models are important tools for conservation, but the usefulness of any given model for decision-making depends on its accuracy and precision. Few models designed for conservation purposes are validated with real-world data, and such models are even less likely to be revisited and improved with post-implementation results. We test the performance of a model frequently used and heavily relied-upon for the management of the endangered red-cockaded woodpecker (Picoides borealis). The RCW Foraging Matrix Application incorporates spatially-explicit forest stand data and woodpecker territory locations to produce quantitative assessments of foraging habitat quality. Model parameters were based on expert opinion and research performed on several key populations at a time when range-wide habitat quality was relatively poor. Since the model's inception, many red-cockaded woodpecker populations have been monitored intensely in restored habitat, providing an opportunity to evaluate model performance range-wide. We assessed the relationship of habitat quality, as measured by the RCW Matrix Application, to group size and fledgling production from populations across the species range in the southeastern United States. We also evaluated foraging habitat quality directly by relating woodpecker fitness components to foraging habitat metrics through regression tree analyses. Results showed that some, but not all, of the habitat metrics included in the RCW Matrix Application were consistently related to fitness components range-wide, but threshold values for these habitat metrics identified by regression tree analyses were site-specific rather than universal. Our findings indicate opportunities for improving on "one-size-fits-all" range-wide models with analyses of additional locally-relevant foraging habitat metrics. (C) 2014 Elsevier Ltd. All rights reserved.
C1 [McKellar, Ann E.; Kesler, Dylan C.] Univ Missouri, Dept Fisheries & Wildlife Sci, Columbia, MO 65211 USA.
[Mitchell, Robert J.] Joseph W Jones Ecol Res Ctr, Newton, GA 39870 USA.
[Delaney, David K.] United States Army Engineer Res & Dev Ctr ERDC, Construct Engn Res Lab, Champaign, IL 61822 USA.
[Walters, Jeffrey R.] Virginia Tech, Dept Biol Sci, Blacksburg, VA 24061 USA.
RP McKellar, AE (reprint author), Environm Canada, 115 Perimeter Rd, Saskatoon, SK S7N 0X4, Canada.
EM ann.mckellar@ec.gc.ca
FU Department of Defense; Engineer Research and Development Center
Construction and Engineering Research Laboratory (ERDC - CERL);
University of Missouri
FX We thank the many members of the Department of Defense and Department of
Agriculture National Forests who shared their data and facilitated data
transfer to the University of Missouri, including M. Barron, J.
Britcher, L. Carlile, S. Carnahan, J. Drake, R. Fleming, J. Gainey, M.
Garner, C. Garrett, N. Hawkins, D. Heins, E. Hoffman, S. Hudson, J.
Maitland, S. Marcantel, T. Marston, C. Medler, W. Montague, K. Moore, D.
Morrow, S. Pulsifer, T.J. Quarles, K. Rutkofske, and J. Schillaci. T.
Hayden, R. Kirgan, W. McDearman, and M. Trager provided valuable
discussion and feedback on earlier drafts. We thank J. Carter, P. Doerr,
the Sandhills Ecological Institute and the many staff, graduate students
and field assistants from Virginia Tech and North Carolina State
University who have contributed to collection of demographic data at
Fort Bragg. We appreciate the helpful comments on early manuscript
drafts provided by F. James and an anonymous reviewer. Funding was
provided through a cooperative agreement between the Engineer Research
and Development Center Construction and Engineering Research Laboratory
(ERDC - CERL) and the University of Missouri. This work was sponsored by
the Department of Defense; the content of the information does not
necessarily reflect the position or the policy of the government, and no
official endorsement should be inferred.
NR 43
TC 5
Z9 5
U1 7
U2 46
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0006-3207
EI 1873-2917
J9 BIOL CONSERV
JI Biol. Conserv.
PD JUL
PY 2014
VL 175
BP 52
EP 64
DI 10.1016/j.biocon.2014.04.007
PG 13
WC Biodiversity Conservation; Ecology; Environmental Sciences
SC Biodiversity & Conservation; Environmental Sciences & Ecology
GA AK7QS
UT WOS:000338623400007
ER
PT J
AU Morris, MJ
Dodson, DW
Lucero, PF
Haislip, GD
Gallup, RA
Nicholson, KL
Zacher, LL
AF Morris, Michael J.
Dodson, Darrel W.
Lucero, Pedro F.
Haislip, Georgette D.
Gallup, Roger A.
Nicholson, Karin L.
Zacher, Lisa L.
TI Study of Active Duty Military for Pulmonary Disease Related to
Environmental Deployment Exposures (STAMPEDE)
SO AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
LA English
DT Article
DE military personnel; deployment; asthma; airborne hazards
ID KUWAIT OIL FIRES; RESPIRATORY SYMPTOMS; CONSTRICTIVE BRONCHIOLITIS;
PARTICULATE MATTER; SOUTHWEST ASIA; LUNG-DISEASE; PERSONNEL; HEALTH;
AFGHANISTAN; POPULATION
AB Rationale: Because of increased levels of airborne particulate matter in Southwest Asia, deployed military personnel are at risk for developing acute and chronic lung diseases. Increased respiratory symptoms are reported, but limited data exist on reported lung diseases.
Objectives: To evaluate new respiratory complaints in military personnel returning from Southwest Asia to determine potential etiologies for symptoms.
Methods: Returning military personnel underwent a prospective standardized evaluation for deployment-related respiratory symptoms within 6 months of returning to their duty station.
Measurements and Main Results: Prospective standardized evaluation included full pulmonary function testing, high-resolution chest tomography, methacholine challenge testing, and fiberoptic bronchoscopy with bronchoalveolar lavage. Other procedures including lung biopsy were performed if clinically indicated. Fifty patients completed the study procedures. A large percentage (42%) remained undiagnosed, including 12% with normal testing and an isolated increase in lavage neutrophils or lymphocytes. Twenty (40%) patients demonstrated some evidence of airway hyperreactivity to include eight who met asthma criteria and two with findings secondary to gastroesophageal reflux. Four (8%) additional patients had isolated reduced diffusing capacity and the remaining six had other miscellaneous airway disorders. No patients were identified with diffuse parenchymal disease on the basis of computed tomography imaging. A significant number (66%) of this cohort had underlying mental health and sleep disorders.
Conclusions: Evaluation of new respiratory symptoms in military personnel after service in Southwest Asia should focus on airway hyperreactivity from exposures to higher levels of ambient particulate matter. These patients may be difficult to diagnose and require close follow-up.
C1 [Morris, Michael J.; Lucero, Pedro F.; Haislip, Georgette D.] San Antonio Mil Med Ctr, Dept Med, Pulm Crit Care Serv, Ft Sam Houston, TX 78234 USA.
[Dodson, Darrel W.] William Beaumont Army Med Ctr, Dept Med, Pulm Crit Care Serv, Ft Bliss, TX USA.
[Gallup, Roger A.; Nicholson, Karin L.] Carl R Darnall Army Med Ctr, Dept Med, Pulm Crit Care Serv, Ft Hood, TX USA.
[Zacher, Lisa L.] Orlando Vet Affairs Med Ctr, Orlando, FL USA.
RP Morris, MJ (reprint author), San Antonio Mil Med Ctr, Pulm Dis Serv MCHE MDP, 3551 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA.
EM michael.j.morris34.civ@mail.mil
NR 38
TC 15
Z9 15
U1 1
U2 7
PU AMER THORACIC SOC
PI NEW YORK
PA 25 BROADWAY, 18 FL, NEW YORK, NY 10004 USA
SN 1073-449X
EI 1535-4970
J9 AM J RESP CRIT CARE
JI Am. J. Respir. Crit. Care Med.
PD JUL 1
PY 2014
VL 190
IS 1
BP 77
EP 84
DI 10.1164/rccm.201402-0372OC
PG 8
WC Critical Care Medicine; Respiratory System
SC General & Internal Medicine; Respiratory System
GA AK3KX
UT WOS:000338323900015
PM 24922562
ER
PT J
AU Klinger, D
Wang, CX
Connal, LA
Audus, DJ
Jang, SG
Kraemer, S
Killops, KL
Fredrickson, GH
Kramer, EJ
Hawker, CJ
AF Klinger, Daniel
Wang, Cynthia X.
Connal, Luke A.
Audus, Debra J.
Jang, Se Gyu
Kraemer, Stephan
Killops, Kato L.
Fredrickson, Glenn H.
Kramer, Edward J.
Hawker, Craig J.
TI A Facile Synthesis of Dynamic, Shape-Changing Polymer Particles
SO ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
LA English
DT Article
DE block copolymers; microgels; nanoparticles; shape anisotropy;
stimuli-responsive materials
ID BLOCK-COPOLYMER NANOPARTICLES; SEPARATED STRUCTURES; GOLD NANOPARTICLES;
PHASE-SEPARATION; THIN-FILMS; BEHAVIOR; SOLVENT; DEFORMATION;
AGGREGATION; ORIENTATION
AB We herein report a new facile strategy to ellipsoidal block copolymer nanoparticles that exhibit a pH-triggered anistropic swelling profile. In a first step, elongated particles with an axially stacked lamellae structure are selectively prepared by utilizing functional surfactants to control the phase separation of symmetric polystyrene-b-poly(2-vinylpyridine) (PS-b-P2VP) in dispersed droplets. In a second step, the dynamic shape change is realized by cross-linking the P2VP domains, thereby connecting glassy PS discs with pH-sensitive hydrogel actuators.
C1 [Klinger, Daniel; Wang, Cynthia X.; Audus, Debra J.; Jang, Se Gyu; Kraemer, Stephan; Fredrickson, Glenn H.; Kramer, Edward J.; Hawker, Craig J.] Univ Calif Santa Barbara, Mat Res Lab, Santa Barbara, CA 93106 USA.
[Connal, Luke A.] Univ Melbourne, Dept Chem & Biomol Engn, Melbourne, Vic 3010, Australia.
[Killops, Kato L.] US Army Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA.
RP Hawker, CJ (reprint author), Univ Calif Santa Barbara, Mat Res Lab, Santa Barbara, CA 93106 USA.
EM hawker@mrl.ucsb.edu
RI Kraemer, Stephan/I-3186-2014;
OI Kraemer, Stephan/0000-0003-0577-7444; Luke, Connal/0000-0001-7519-977X
FU MRSEC Program of the National Science Foundation (NSF) [DMR-1121053];
Institute for Collaborative Biotechnologies through U.S. Army Research
Office [W911NF-09-0001]; National Heart, Lung, and Blood Institute,
National Institutes of Health, Department of Health and Human Services
[HHSN268201000046C]
FX This work was supported by the MRSEC Program of the National Science
Foundation (NSF) under Award DMR-1121053 (L. A. C., D.J.A., S. K.,
E.J.K., and C.J.H.), the Institute for Collaborative Biotechnologies
through grant W911NF-09-0001 from the U.S. Army Research Office (D. K.,
S.G.J., K. L. K., G. H. F., and C.J.H.), and the National Heart, Lung,
and Blood Institute, National Institutes of Health, Department of Health
and Human Services, under Contract No. HHSN268201000046C (D. K., C. W.,
and C.J.H.). Facilities support from the CNSI-MRL Center for Scientific
Computing (DMR-1121053 and CNS-0960316) is acknowledged. The content of
the information does not necessarily reflect the position or the policy
of the US government and no official endorsement should be inferred.
NR 49
TC 45
Z9 45
U1 25
U2 208
PU WILEY-V C H VERLAG GMBH
PI WEINHEIM
PA BOSCHSTRASSE 12, D-69469 WEINHEIM, GERMANY
SN 1433-7851
EI 1521-3773
J9 ANGEW CHEM INT EDIT
JI Angew. Chem.-Int. Edit.
PD JUL
PY 2014
VL 53
IS 27
BP 7018
EP 7022
DI 10.1002/anie.201400183
PG 5
WC Chemistry, Multidisciplinary
SC Chemistry
GA AJ9IR
UT WOS:000338023000035
PM 24700705
ER
PT J
AU Johnson, JC
Martinez, O
Honko, AN
Hensley, LE
Olinger, GG
Basler, CF
AF Johnson, Joshua C.
Martinez, Osvaldo
Honko, Anna N.
Hensley, Lisa E.
Olinger, Gene G.
Basler, Christopher F.
TI Pyridinyl imidazole inhibitors of p38 MAP kinase impair viral entry and
reduce cytokine induction by Zaire ebolavirus in human dendritic cells
SO ANTIVIRAL RESEARCH
LA English
DT Article
DE Ebola virus; p38 MAPK; Dendritic cell; THP-1; Entry; Antigen-presenting
cell
ID ACTIVATED PROTEIN-KINASE; NF-KAPPA-B; VIRUS-INFECTION;
HEMORRHAGIC-FEVER; MONOCYTE DIFFERENTIATION; SIGNALING PATHWAY;
REPLICATION; PATHOGENESIS; MATURATION; TARGETS
AB Antigen presenting cells (APCs), including macrophages and dendritic cells, are early and sustained targets of Ebola virus (EBOV) infection in vivo. Because EBOV activates mitogen-activated protein kinase (MAPK) signaling upon infection of APCs, we evaluated the effect of pyridinyl imidazole inhibitors of p38 MAPK on EBOV infection of human APCs and EBOV mediated cytokine production from human DCs. The p38 MAPK inhibitors reduced viral replication in PMA-differentiated macrophage-like human THP-1 cells with an IC50 of 4.73 mu M (SB202190), 8.26 mu M (p38kinhIII) and 8.21 mu M (SB203580) and primary human monocyte-derived dendritic cells (MDDCs) with an IC50 of 2.67 mu M (SB202190). Furthermore, cytokine production from EBOV-treated MDDCs was inhibited in a dose-dependent manner. A control pyridinyl imidazole compound failed to inhibit either EBOV infection or cytokine induction. Using an established EBOV virus-like particle (VLP) entry assay, we demonstrate that inhibitor pretreatment blocked VLP entry suggesting that the inhibitors blocked infection and replication at least in part by blocking EBOV entry. Taken together, our results indicate that pyridinyl imidazole p38 MAPK inhibitors may serve as leads for the development of therapeutics to treat EBOV infection. (C) 2014 Elsevier B.V. All rights reserved.
C1 [Johnson, Joshua C.; Honko, Anna N.; Hensley, Lisa E.; Olinger, Gene G.] US Army Med Res Inst Infect Dis, Div Virol, Ft Detrick, MD 21702 USA.
[Martinez, Osvaldo; Basler, Christopher F.] Icahn Sch Med Mt Sinai, Dept Microbiol, New York, NY 10029 USA.
RP Basler, CF (reprint author), Icahn Sch Med Mt Sinai, Dept Microbiol, Box 1124,1 Gustave L Levy Pl, New York, NY 10029 USA.
EM chris.basler@mssm.edu
OI Johnson, Joshua/0000-0002-5677-3841; Honko, Anna/0000-0001-9165-148X
FU NIH [AI097568, AI109664, AI057158]
FX This work was supported by NIH grants AI097568, AI109664 and AI057158
(Northeast Biodefense Center-Lipkin) to C.F.B. We thank Dr. Victor E.
Marquez (National Cancer Institute) for providing DZNep. Opinions,
interpretations, conclusions, and recommendations are those of the
authors and are not necessarily endorsed by the U.S. Army.
NR 57
TC 11
Z9 12
U1 0
U2 42
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0166-3542
EI 1872-9096
J9 ANTIVIR RES
JI Antiviral Res.
PD JUL
PY 2014
VL 107
BP 102
EP 109
DI 10.1016/j.antiviral.2014.04.014
PG 8
WC Pharmacology & Pharmacy; Virology
SC Pharmacology & Pharmacy; Virology
GA AK4RT
UT WOS:000338412500014
PM 24815087
ER
PT J
AU Schoepp, RJ
Rossi, CA
Khan, SH
Goba, A
Fair, JN
AF Schoepp, Randal J.
Rossi, Cynthia A.
Khan, Sheik H.
Goba, Augustine
Fair, Joseph N.
TI Undiagnosed Acute Viral Febrile Illnesses, Sierra Leone
SO EMERGING INFECTIOUS DISEASES
LA English
DT Article
ID RIFT-VALLEY-FEVER; LASSA HEMORRHAGIC-FEVER; OUTCOME CASE-REPORT;
WEST-AFRICA; VIRUS; ANTIBODIES; CONGO; REEMERGENCE; INFECTIONS;
MAURITANIA
AB Sierra Leone in West Africa is in a Lassa fever hyperendemic region that also includes Guinea and Liberia. Each year, suspected Lassa fever cases result in submission of approximate to 500-700 samples to the Kenema Government Hospital Lassa Diagnostic Laboratory in eastern Sierra Leone. Generally only 30%-40% of samples tested are positive for Lassa virus (LASV) antigen and/or LASV-specific IgM; thus, 60%-70% of these patients have acute diseases of unknown origin. To investigate what other arthropod-borne and hemorrhagic fever viral diseases might cause serious illness in this region and mimic Lassa fever, we tested patient serum samples that were negative for malaria parasites and LASV. Using IgM-capture ELISAs, we evaluated samples for antibodies to arthropod-borne and other hemorrhagic fever viruses. Approximately 25% of LASV-negative patients had IgM to dengue, West Nile, yellow fever, Rift Valley fever, chikungunya, Ebola, and Marburg viruses but not to Crimean-Congo hemorrhagic fever virus.
C1 [Schoepp, Randal J.; Rossi, Cynthia A.] US Army Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA.
[Khan, Sheik H.; Goba, Augustine] Kenema Govt Hosp, Kenema, Sierra Leone.
[Fair, Joseph N.] Metabiota, San Francisco, CA USA.
RP Schoepp, RJ (reprint author), US Army Med Res Inst Infect Dis, Diagnost Syst Div, 1425 Porter St, Ft Detrick, MD 21702 USA.
EM randal.j.schoepp.civ@mail.mil
FU Division of Global Emerging Infections Surveillance and Response System
Operations at the Armed Forces Health Surveillance Center through
USAMRIID [C0169_10_RD, C0410_11_RD, C0602_12_RD]; US Department of
Defense Cooperative Biological Engagement Program through Metabiota,
Inc., San Francisco, CA, USA
FX The laboratory work was funded in part by the Division of Global
Emerging Infections Surveillance and Response System Operations at the
Armed Forces Health Surveillance Center, Research Plans (C0169_10_RD,
C0410_11_RD, and C0602_12_RD), through USAMRIID and by the US Department
of Defense Cooperative Biological Engagement Program, through Metabiota,
Inc., San Francisco, CA, USA.
NR 39
TC 48
Z9 50
U1 0
U2 55
PU CENTERS DISEASE CONTROL
PI ATLANTA
PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA
SN 1080-6040
EI 1080-6059
J9 EMERG INFECT DIS
JI Emerg. Infect. Dis
PD JUL
PY 2014
VL 20
IS 7
BP 1176
EP 1182
DI 10.3201/eid2007.131265
PG 7
WC Immunology; Infectious Diseases
SC Immunology; Infectious Diseases
GA AK4JB
UT WOS:000338389900011
PM 24959946
ER
PT J
AU Smith, R
Stain, SC
McFadden, DW
Finlayson, SRG
Jones, DB
Reid-Lombardo, K
AF Smith, Richard
Stain, Steven C.
McFadden, David W.
Finlayson, Samuel R. G.
Jones, Daniel B.
Reid-Lombardo, KMarie
CA SSAT
TI Will There Be a Good General Surgeon When You Need One? (Part II)
Solutions and Taking Back General Surgery
SO JOURNAL OF GASTROINTESTINAL SURGERY
LA English
DT Article; Proceedings Paper
CT 54th Annual Meeting of the Society-for-Surgery-of-the-Alimentary-Tract
(SSAT) / Digestive Disease Week (DDW)
CY MAY 17-21, 2013
CL Orlando, FL
SP Soc Surg Alimentary Tract
DE Surgeon Shortage; Health care policy; Affordable health care act;
Advocacy; Workforce; SSAT
ID REGIONAL-VARIATIONS; UNITED-STATES; CARE; WORKFORCE; RESIDENTS; QUALITY
AB Multiple reports have cited the looming shortage of physicians over the next decades related to increasing demand, an aging of the population, and a stagnant level in the production of new physicians. General surgery shares in this problem, and the specialty is "stressed" by a declining workforce related to increasing specialization that leaves gaps in emergency, trauma, and rural surgical care.
The Society of Surgery of the Alimentary Tract (SSAT) Public Policy and Advocacy Committee sponsored panel discussions regarding the general surgery workforce shortage at the Digestive Disease Week 2012 and 2013 meetings. The 2012 panel focused on defining the problem. This is the summation of the series with the solutions to the general surgery workforce shortage as offered by the 2013 panel.
C1 [Smith, Richard] Tripler Army Med Ctr, Honolulu, HI 96859 USA.
[Stain, Steven C.] Albany Med Coll, Dept Surg, Albany, NY 12208 USA.
[McFadden, David W.] Univ Connecticut, Dept Surg, Farmington, CT USA.
[Finlayson, Samuel R. G.; Jones, Daniel B.] Beth Israel Deaconess Med Ctr, Dept Surg, Boston, MA 02215 USA.
[SSAT] Soc Surg Alimentary Tract, Beverly, MA USA.
[Reid-Lombardo, KMarie] Mayo Clin, Dept Surg, Rochester, MN 55905 USA.
RP Reid-Lombardo, K (reprint author), Mayo Clin, Dept Surg, 200 First St SW, Rochester, MN 55905 USA.
EM Reidlombardo.kaye@mayo.edu
FU NHLBI NIH HHS [R01 HL119248]; NIBIB NIH HHS [R01 EB010037, R01 EB014305,
R01 EB005807, R01 EB009362]
NR 34
TC 3
Z9 3
U1 0
U2 1
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1091-255X
EI 1873-4626
J9 J GASTROINTEST SURG
JI J. Gastrointest. Surg.
PD JUL
PY 2014
VL 18
IS 7
BP 1334
EP 1342
DI 10.1007/s11605-014-2522-4
PG 9
WC Gastroenterology & Hepatology; Surgery
SC Gastroenterology & Hepatology; Surgery
GA AK0QD
UT WOS:000338118600018
PM 24748342
ER
PT J
AU Rives, T
AF Rives, Tim
TI Like Footprints in the Sand: Searching for Eisenhower's Climactic D-Day
Words
SO JOURNAL OF MILITARY HISTORY
LA English
DT Article
AB Given the importance of General Dwight D. Eisenhower's decision to launch the invasion of Normandy on 6 June 1944, both to the outcome of the war and to him personally, it is mysterious that neither he nor the commanders who witnessed his supreme moment could agree on what he said when he set the Allied force in motion. While the fog of war explains some of the discrepancies in the eyewitness accounts, Eisenhower's modest character also plays a role in the mystery. Seventy years later, we still do not know what words unleashed the Allied assault on the Atlantic Wall.
C1 [Rives, Tim] Eisenhower Presidential Lib Museum & Boyhood Home, Abilene, KS 67410 USA.
[Rives, Tim] Natl Archives, Kansas City, MO USA.
[Rives, Tim] US Army, Washington, DC USA.
RP Rives, T (reprint author), Eisenhower Presidential Lib Museum & Boyhood Home, Abilene, KS 67410 USA.
NR 42
TC 0
Z9 0
U1 0
U2 2
PU SOC MILITARY HISTORY
PI LEXINGTON
PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA
24450-1600 USA
SN 0899-3718
EI 1543-7795
J9 J MILITARY HIST
JI J. Mil. Hist.
PD JUL
PY 2014
VL 78
IS 3
BP 1057
EP 1067
PG 11
WC History
SC History
GA AK4IC
UT WOS:000338386900006
ER
PT J
AU House, JM
AF House, Jonathan M.
TI Three German Invasions of France: The Summer Campaigns of
1870-1914-1940.
SO JOURNAL OF MILITARY HISTORY
LA English
DT Book Review
C1 [House, Jonathan M.] US Army Command & Gen Staff Coll, Ft Leavenworth, KS 66027 USA.
RP House, JM (reprint author), US Army Command & Gen Staff Coll, Ft Leavenworth, KS 66027 USA.
NR 1
TC 0
Z9 0
U1 1
U2 2
PU SOC MILITARY HISTORY
PI LEXINGTON
PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA
24450-1600 USA
SN 0899-3718
EI 1543-7795
J9 J MILITARY HIST
JI J. Mil. Hist.
PD JUL
PY 2014
VL 78
IS 3
BP 1135
EP 1136
PG 2
WC History
SC History
GA AK4IC
UT WOS:000338386900037
ER
PT J
AU Hull, MM
AF Hull, Mark M.
TI Ireland during the Second World War: Farewell to Plato's Cave
SO JOURNAL OF MILITARY HISTORY
LA English
DT Book Review
C1 [Hull, Mark M.] US Army, Command & Gen Staff Coll, Ft Leavenworth, KS 66027 USA.
RP Hull, MM (reprint author), US Army, Command & Gen Staff Coll, Ft Leavenworth, KS 66027 USA.
NR 1
TC 0
Z9 0
U1 0
U2 0
PU SOC MILITARY HISTORY
PI LEXINGTON
PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA
24450-1600 USA
SN 0899-3718
EI 1543-7795
J9 J MILITARY HIST
JI J. Mil. Hist.
PD JUL
PY 2014
VL 78
IS 3
BP 1164
EP 1165
PG 2
WC History
SC History
GA AK4IC
UT WOS:000338386900056
ER
PT J
AU Shepard, NP
Westrick, RB
Johnson, MR
AF Shepard, Nathan P.
Westrick, Richard B.
Johnson, Michael R.
TI MUSCULOSKELETAL IMAGING
SO JOURNAL OF ORTHOPAEDIC & SPORTS PHYSICAL THERAPY
LA English
DT Editorial Material
C1 [Shepard, Nathan P.; Westrick, Richard B.; Johnson, Michael R.] Baylor Univ Sports Phys Therapy Doctoral Residenc, US Army, Keller Army Community Hosp, West Point, NY 10996 USA.
RP Shepard, NP (reprint author), Baylor Univ Sports Phys Therapy Doctoral Residenc, US Army, Keller Army Community Hosp, West Point, NY 10996 USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU J O S P T,
PI ALEXANDRIA
PA 1111 NORTH FAIRFAX ST, STE 100, ALEXANDRIA, VA 22314-1436 USA
SN 0190-6011
J9 J ORTHOP SPORT PHYS
JI J. Orthop. Sports Phys. Ther.
PD JUL
PY 2014
VL 44
IS 7
BP 541
EP 541
DI 10.2519/jospt.2014.0408
PG 1
WC Orthopedics; Rehabilitation; Sport Sciences
SC Orthopedics; Rehabilitation; Sport Sciences
GA AK4KU
UT WOS:000338394400010
PM 24981223
ER
PT J
AU Pollara, J
Bonsignori, M
Moody, MA
Liu, PH
Alam, SM
Hwang, KK
Gurley, TC
Kozink, DM
Armand, LC
Marshall, DJ
Whitesides, JF
Kaewkungwal, J
Nitayaphan, S
Pitisuttithum, P
Rerks-Ngarm, S
Robb, ML
O'Connell, RJ
Kim, JH
Michael, NL
Montefiori, DC
Tomaras, GD
Liao, HX
Haynes, BF
Ferrari, G
AF Pollara, Justin
Bonsignori, Mattia
Moody, M. Anthony
Liu, Pinghuang
Alam, S. Munir
Hwang, Kwan-Ki
Gurley, Thaddeus C.
Kozink, Daniel M.
Armand, Lawrence C.
Marshall, Dawn J.
Whitesides, John F.
Kaewkungwal, Jaranit
Nitayaphan, Sorachai
Pitisuttithum, Punnee
Rerks-Ngarm, Supachai
Robb, Merlin L.
O'Connell, Robert J.
Kim, Jerome H.
Michael, Nelson L.
Montefiori, David C.
Tomaras, Georgia D.
Liao, Hua-Xin
Haynes, Barton F.
Ferrari, Guido
TI HIV-1 Vaccine-Induced C1 and V2 Env-Specific Antibodies Synergize for
Increased Antiviral Activities
SO JOURNAL OF VIROLOGY
LA English
DT Article
ID IMMUNODEFICIENCY-VIRUS TYPE-1; HUMAN MONOCLONAL-ANTIBODIES; DEPENDENT
CELLULAR CYTOTOXICITY; BROADLY NEUTRALIZING ANTIBODIES; CD4-BINDING
SITE; VIRION CAPTURE; EFFICACY TRIAL; IGG BINDING; SUBTYPE-B; V3 LOOP
AB The RV144 ALVAC/AIDSVax HIV-1 vaccine clinical trial showed an estimated vaccine efficacy of 31.2%. Viral genetic analysis identified a vaccine-induced site of immune pressure in the HIV-1 envelope (Env) variable region 2 (V2) focused on residue 169, which is included in the epitope recognized by vaccinee-derived V2 monoclonal antibodies. The ALVAC/AIDSVax vaccine induced antibody-dependent cellular cytotoxicity (ADCC) against the Env V2 and constant 1 (C1) regions. In the presence of low IgA Env antibody levels, plasma levels of ADCC activity correlated with lower risk of infection. In this study, we demonstrate that C1 and V2 monoclonal antibodies isolated from RV144 vaccinees synergized for neutralization, infectious virus capture, and ADCC. Importantly, synergy increased the HIV-1 ADCC activity of V2 monoclonal antibody CH58 at concentrations similar to that observed in plasma of RV144 vaccinees. These findings raise the hypothesis that synergy among vaccine-induced antibodies with different epitope specificities contributes to HIV-1 antiviral antibody responses and is important to induce for reduction in the risk of HIV-1 transmission.
IMPORTANCE
The Thai RV144 ALVAC/AIDSVax prime-boost vaccine efficacy trial represents the only example of HIV-1 vaccine efficacy in humans to date. Studies aimed at identifying immune correlates involved in the modest vaccine-mediated protection identified HIV-1 envelope (Env) variable region 2-binding antibodies as inversely correlated with infection risk, and genetic analysis identified a site of immune pressure within the region recognized by these antibodies. Despite this evidence, the antiviral mechanisms by which variable region 2-specific antibodies may have contributed to lower rates of infection remain unclear. In this study, we demonstrate that vaccine-induced HIV-1 envelope variable region 2 and constant region 1 antibodies synergize for recognition of virus-infected cells, infectious virion capture, virus neutralization, and antibody-dependent cellular cytotoxicity. This is a major step in understanding how these types of antibodies may have cooperatively contributed to reducing infection risk and should be considered in the context of prospective vaccine design.
C1 [Pollara, Justin; Bonsignori, Mattia; Moody, M. Anthony; Liu, Pinghuang; Alam, S. Munir; Hwang, Kwan-Ki; Gurley, Thaddeus C.; Kozink, Daniel M.; Armand, Lawrence C.; Marshall, Dawn J.; Whitesides, John F.; Montefiori, David C.; Tomaras, Georgia D.; Liao, Hua-Xin; Haynes, Barton F.; Ferrari, Guido] Duke Univ, Med Ctr, Duke Human Vaccine Inst, Durham, NC 27708 USA.
[Pollara, Justin; Montefiori, David C.; Tomaras, Georgia D.; Ferrari, Guido] Duke Univ, Med Ctr, Dept Surg, Durham, NC 27710 USA.
[Bonsignori, Mattia; Alam, S. Munir; Whitesides, John F.; Liao, Hua-Xin; Haynes, Barton F.] Duke Univ, Med Ctr, Dept Med, Durham, NC 27710 USA.
[Moody, M. Anthony] Duke Univ, Med Ctr, Dept Infect Dis, Durham, NC USA.
[Moody, M. Anthony] Duke Univ, Med Ctr, Dept Pediat, Durham, NC 27710 USA.
[Alam, S. Munir] Duke Univ, Med Ctr, Dept Pathol, Durham, NC 27710 USA.
[Tomaras, Georgia D.; Haynes, Barton F.] Duke Univ, Med Ctr, Dept Immunol, Durham, NC USA.
[Tomaras, Georgia D.] Duke Univ, Med Ctr, Dept Mol Genet & Microbiol, Durham, NC USA.
[Kaewkungwal, Jaranit] Mahidol Univ, Fac Trop Med, Ctr Excellence Biomed & Publ Hlth Informat BIOPHI, Bangkok, Thailand.
[Nitayaphan, Sorachai; O'Connell, Robert J.] AFRIMS, Dept Retrovirol, US Army Med Component, Bangkok, Thailand.
[Pitisuttithum, Punnee] Mahidol Univ, Bangkok 10700, Thailand.
[Rerks-Ngarm, Supachai] Minist Publ Hlth, Dept Dis Control, Nonthaburi, Thailand.
[Robb, Merlin L.; Kim, Jerome H.; Michael, Nelson L.] US Mil HIV Res Program, Bethesda, MD USA.
RP Ferrari, G (reprint author), Duke Univ, Med Ctr, Duke Human Vaccine Inst, Durham, NC 27708 USA.
EM gflmp@duke.edu
RI Ferrari, Guido/A-6088-2015; Tomaras, Georgia/J-5041-2016
FU Center for HIV/AIDS Vaccine Immunology-Immunogen Discovery (CHAVI-ID);
CHAVI [UM-AI100645, U01 AI067854]; National Institutes of Health
(NIH/NIAID/DAIDS); Bill and Melinda Gates Foundation's Collaboration for
AIDS Vaccine Discovery [1033098, 1040758, 1032144, 1032325, 64518]; U.
S. Army Medical Research and Material Command (USAMRMC) [Y1-AI-2642-12];
National Institutes of Allergy and Infectious Diseases
[W81XWH-07-2-0067]; Foundation for the Advancement of Military Medicine,
Inc.; U. S. Department of Defense (DOD); NIH; NIAID [AI07392]
FX This work was supported by the Center for HIV/AIDS Vaccine
Immunology-Immunogen Discovery (CHAVI-ID) and CHAVI (UM-AI100645 and U01
AI067854), National Institutes of Health (NIH/NIAID/DAIDS), Bill and
Melinda Gates Foundation's Collaboration for AIDS Vaccine Discovery
Grants (Haynes B Cell Lineage [1033098] and Haynes IgA [1040758],
Montefiori CA-VIMC [1032144], Koup CT-VIMC [1032325]), 64518). In
addition, funding was provided by Interagency Agreement Y1-AI-2642-12
between U. S. Army Medical Research and Material Command (USAMRMC) and
the National Institutes of Allergy and Infectious Diseases through a
cooperative agreement (W81XWH-07-2-0067) between the Henry M. Jackson
Foundation for the Advancement of Military Medicine, Inc., and the U. S.
Department of Defense (DOD). J. P. was supported by NIH, NIAID grant
AI07392.
NR 38
TC 47
Z9 47
U1 1
U2 13
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0022-538X
EI 1098-5514
J9 J VIROL
JI J. Virol.
PD JUL
PY 2014
VL 88
IS 14
BP 7715
EP 7726
DI 10.1128/JVI.00156-14
PG 12
WC Virology
SC Virology
GA AK5CT
UT WOS:000338442600005
PM 24807721
ER
PT J
AU Smith, R
AF Smith, Roger
TI Innovate Like It's 1985
SO RESEARCH-TECHNOLOGY MANAGEMENT
LA English
DT Editorial Material
C1 [Smith, Roger] Florida Hosp, Nicholson Ctr Surg Adv, Orlando, FL 32803 USA.
[Smith, Roger] US Army Simulat, Orlando, FL USA.
[Smith, Roger] Titan Corp, San Diego, CA USA.
[Smith, Roger] BTG Inc, Technol, Jacksonville, FL USA.
RP Smith, R (reprint author), Florida Hosp, Nicholson Ctr Surg Adv, Orlando, FL 32803 USA.
EM roger.smith@flhosp.org
NR 0
TC 0
Z9 0
U1 0
U2 1
PU INDUSTRIAL RESEARCH INST, INC
PI ARLINGTON
PA 2300 CLARENDON BLVD, STE 400, ARLINGTON, VA 22201 USA
SN 0895-6308
EI 1930-0166
J9 RES TECHNOL MANAGE
JI Res.-Technol. Manage.
PD JUL-AUG
PY 2014
VL 57
IS 4
BP 53
EP 55
DI 10.5437/08956308X5704007
PG 3
WC Business; Engineering, Industrial; Management
SC Business & Economics; Engineering
GA AK0IB
UT WOS:000338095000012
ER
PT J
AU Rajagopalan, M
Bhatia, MA
Tschopp, MA
Srolovitz, DJ
Solanki, KN
AF Rajagopalan, M.
Bhatia, M. A.
Tschopp, M. A.
Srolovitz, D. J.
Solanki, K. N.
TI Atomic-scale analysis of liquid-gallium embrittlement of aluminum grain
boundaries
SO ACTA MATERIALIA
LA English
DT Article
DE Liquid metal embrittlement; Atomistic simulation; Grain boundary;
Segregation
ID 5 MACROSCOPIC PARAMETERS; SYMMETRICAL TILT BOUNDARIES; TOTAL-ENERGY
CALCULATIONS; AUGMENTED-WAVE METHOD; METAL EMBRITTLEMENT;
CHARACTER-DISTRIBUTION; SOLUTE SEGREGATION; MOLECULAR-DYNAMICS; CUBIC
METALS; FCC METALS
AB Material strengthening and embrittlement are controlled by intrinsic interactions between defects, such as grain boundaries (GBs), and impurity atoms that alter the observed deformation and failure mechanisms in metals. In this work, we explore the role of atomistic-scale energetics on liquid-metal embrittlement of aluminum (Al) due to gallium (Ga). Ab initio and molecular mechanics were employed to probe the formation/binding energies of vacancies and segregation energies of Ga for < 1 0 0 >, < 1 1 0 > and < 1 1 1 > symmetric tilt grain boundaries (STGBs) in Al. We found that the GB local arrangements and resulting structural units have a significant influence on the magnitude of the vacancy binding energies. For example, the mean vacancy binding energies for < 1 0 0 >, < 1 1 0 > and < 1 1 1 > STGBs in the 1st layer was found to be -0.63, -0.26 and -0.60 eV, respectively. However, some GBs exhibited vacancy binding energies closer to bulk values, indicating interfaces with zero sink strength, i.e. these GBs may not provide effective pathways for vacancy diffusion. The results from the present work showed that the GB structure and the associated free volume also play significant roles in Ga segregation and the subsequent embrittlement of Al. The Ga mean segregation energies for < 1 0 0 >, < 1 1 0 > and < 1 1 1 > STGBs in the 1st layer were found to be -0.21, -0.09 and -0.21 eV, respectively, suggesting a stronger correlation between the GB structural unit, its free volume and the segregation behavior. Furthermore, as the GB free volume increased, the difference in segregation energies between the 1st layer and the 0th layer increased. Thus, the GB character and free volume provide an important key to understanding the degree of anisotropy in various systems. The overall characteristic Ga absorption length scale was found to be about similar to 10, 8 and 12 layers for < 1 0 0 >, < 1 1 0 > and < 1 1 1 > STGBs, respectively. In addition, a few GBs of different tilt axes with relatively high segregation energies (between 0 and -0.1 eV) at the boundary were also found. This finding provides a new atomistic perspective for the GB engineering of materials with smart GB networks to mitigate or control liquid-metal embrittlement and more general embrittlement phenomena in alloys. (C) 2014 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
C1 [Rajagopalan, M.; Bhatia, M. A.; Solanki, K. N.] Arizona State Univ, Sch Engn Matter Transport & Energy, Tempe, AZ 85281 USA.
[Tschopp, M. A.] US Army, Ballist Res Lab, Dynam Res Corp, High Peiformance Technol Grp, Aberdeen Proving Ground, MD 21005 USA.
[Srolovitz, D. J.] Univ Penn, Dept Mat Sci & Engn, Philadelphia, PA 19104 USA.
[Srolovitz, D. J.] Univ Penn, Dept Mech Engn & Appl Mech, Philadelphia, PA 19104 USA.
RP Solanki, KN (reprint author), Arizona State Univ, Sch Engn Matter Transport & Energy, Tempe, AZ 85281 USA.
EM kiran.solanki@asu.edu
RI Solanki, Kiran/E-8337-2010;
OI Tschopp, Mark/0000-0001-8471-5035
FU Office of Naval Research [N000141110793]; U.S. Army Research Laboratory
(ARL); US Department of Energy; ARL
FX The authors acknowledge useful insights and suggestions from Dr. W.
Mullins and Dr. A.K. Vasudevan from the Office of Naval Research. This
work was supported by the Office of Naval Research, Contract No.
N000141110793. M.A.T. acknowledges the support of the U.S. Army Research
Laboratory (ARL) administered by the Oak Ridge Institute for Science and
Education through an interagency agreement between the US Department of
Energy and ARL.
NR 78
TC 20
Z9 20
U1 9
U2 51
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 1359-6454
EI 1873-2453
J9 ACTA MATER
JI Acta Mater.
PD JUL
PY 2014
VL 73
BP 312
EP 325
DI 10.1016/j.actamat.2014.04.011
PG 14
WC Materials Science, Multidisciplinary; Metallurgy & Metallurgical
Engineering
SC Materials Science; Metallurgy & Metallurgical Engineering
GA AJ7BV
UT WOS:000337853100029
ER
PT J
AU Larentzos, JP
Brennan, JK
Moore, JD
Lisal, M
Mattson, WD
AF Larentzos, James P.
Brennan, John K.
Moore, Joshua D.
Lisal, Martin
Mattson, William D.
TI Parallel implementation of isothermal and isoenergetic Dissipative
Particle Dynamics using Shardlow-like splitting algorithms
SO COMPUTER PHYSICS COMMUNICATIONS
LA English
DT Article
DE Dissipative Particle Dynamics; DPD; Shardlow splitting algorithm;
Numerical integration; Parallelization
ID ENERGY-CONSERVATION; SIMULATIONS; INTEGRATORS; MODELS
AB A parallel implementation of the Shardlow splitting algorithm (SSA) for Dissipative Particle Dynamics (DPD) simulations is presented. The isothermal and isoenergetic SSA implementations are compared to the DPD version of the velocity-Verlet integrator in terms of numerical stability and performance. The integrator stability is assessed by monitoring temperature, pressure and total energy for both the standard and ideal DPD fluid models. The SSA requires special consideration due to its recursive nature resulting in more inter-processor communication as compared to traditional DPD integrators. Nevertheless, this work demonstrates that the SSA exhibits stability over longer time steps that justify its regular use in parallel, multi-core applications. For the computer architecture used in this study, a factor of 10-100 speedup is achieved in the overall time-to-solution for isoenergetic DPD simulations and a 15-34 speedup is achieved for the isothermal DPD simulations. 2014 Elsevier B.V. All rights reserved.
C1 [Larentzos, James P.] US Army, Ballist Res Lab, Engil Corp, Aberdeen Proving Ground, MD 21005 USA.
[Brennan, John K.; Moore, Joshua D.; Mattson, William D.] US Army, Army Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA.
[Lisal, Martin] Acad Sci Czech Republic, Inst Chem Proc Fundamentals, Vvi, E Hala Lab Thermodynam, CR-16502 Prague, Czech Republic.
[Lisal, Martin] Univ JE Purkyne, Fac Sci, Dept Phys, Usti Nad Labem, Czech Republic.
RP Larentzos, JP (reprint author), US Army, Ballist Res Lab, Engil Corp, Aberdeen Proving Ground, MD 21005 USA.
EM James.Larentzos@engilitycorp.com
RI Lisal, Martin/A-8176-2011
OI Lisal, Martin/0000-0001-8005-7143
FU Oak Ridge Associated Universities through US Army Research Laboratory;
Office of Naval Research [12-001]; Department of Defense High
Performance Computing Modernization Program Software Application
Institute for Multiscale Reactive Modeling of Insensitive Munitions;
Army Research Laboratory [W911NF-10-2-0039]
FX The authors would like to thank Jean-Bernard Mail let (Commissariat a
l'energie atomique et aux energies alternatives, DAM) and Betsy M. Rice
(US Army Research Laboratory) for insightful discussions. JPL and JKB
acknowledge Timothy Sirk (US Army Research Laboratory) and Timothy
Mattox (Engility Corporation) for useful discussions in parallelizing
the Shard low splitting algorithm. The authors acknowledge the
computational resources and PETTT software support from the High
Performance Computing Modernization office. JDM acknowledges support in
part by an appointment to the US Army Research Laboratory Postdoctoral
Fellowship Program administered by the Oak Ridge Associated Universities
through a cooperative agreement with the US Army Research Laboratory.
JKB and JDM acknowledge support in part by the Office of Naval Research
(BAA number 12-001) and the Department of Defense High Performance
Computing Modernization Program Software Application Institute for
Multiscale Reactive Modeling of Insensitive Munitions. ML acknowledges
that this research was sponsored by the Army Research Laboratory and was
accomplished under Cooperative Agreement Number W911NF-10-2-0039. The
views and conclusions contained in this document are those of the
authors and should not be interpreted as representing the official
policies, either expressed or implied, of the Army Research Laboratory
or the US Government. The US Government is authorized to reproduce and
distribute reprints for Government purposes notwithstanding any
copyright notation herein.
NR 34
TC 5
Z9 5
U1 4
U2 24
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0010-4655
EI 1879-2944
J9 COMPUT PHYS COMMUN
JI Comput. Phys. Commun.
PD JUL
PY 2014
VL 185
IS 7
BP 1987
EP 1998
DI 10.1016/j.cpc.2014.03.029
PG 12
WC Computer Science, Interdisciplinary Applications; Physics, Mathematical
SC Computer Science; Physics
GA AJ5ZF
UT WOS:000337768700015
ER
PT J
AU Allen, JB
AF Allen, J. B.
TI Simulations of Anisotropic Grain Growth Involving Two-Phase
Nanocrystalline/Amorphous Systems Using Q-State Monte Carlo
SO JOURNAL OF ENGINEERING MATERIALS AND TECHNOLOGY-TRANSACTIONS OF THE ASME
LA English
DT Article
ID COMPUTER-SIMULATION; BOUNDARY MOBILITY; MICROSTRUCTURE; EVOLUTION;
PHASE; ALGORITHM; COATINGS; KINETICS; FILMS; MODEL
AB The present work incorporates an implementation of the two dimensional, Q-state Monte Carlo method to evaluate anisotropic grain growth in two-phase nanocrystalline/amorphous systems. Specifically, anisotropic grain boundaries are simulated via the use of surface energies and binding energies; the former attributable to the variation in grain orientation and assigned through a mapping process involving Wulff plots. The secondary, amorphous phase is randomly assigned to the lattice in accordance with a specified initial volume fraction. Among other findings, the results reveal that the grain boundary surface energy, as governed by the shape of the Wulff plot, plays a critical role in the resulting microstructure. Additionally, it was found that the addition of a secondary amorphous phase to an existing anisotropic grain boundary system evolves into primary grain microstructures characteristic of single phase isotropic systems.
C1 US Army Engineer Res & Dev Ctr, Informat Technol Lab, Vicksburg, MS 39180 USA.
RP Allen, JB (reprint author), US Army Engineer Res & Dev Ctr, Informat Technol Lab, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA.
EM jeffrey.b.allen@erdc.dren.mil
NR 35
TC 0
Z9 0
U1 2
U2 13
PU ASME
PI NEW YORK
PA TWO PARK AVE, NEW YORK, NY 10016-5990 USA
SN 0094-4289
EI 1528-8889
J9 J ENG MATER-T ASME
JI J. Eng. Mater. Technol.-Trans. ASME
PD JUL
PY 2014
VL 136
IS 3
AR 031004
DI 10.1115/1.4027323
PG 7
WC Engineering, Mechanical; Materials Science, Multidisciplinary
SC Engineering; Materials Science
GA AJ7VN
UT WOS:000337908000004
ER
PT J
AU Phadikar, JK
Bogetti, TA
Karlsson, AM
AF Phadikar, J. K.
Bogetti, T. A.
Karlsson, A. M.
TI Aspects of Experimental Errors and Data Reduction Schemes From Spherical
Indentation of Isotropic Materials
SO JOURNAL OF ENGINEERING MATERIALS AND TECHNOLOGY-TRANSACTIONS OF THE ASME
LA English
DT Article
DE indentation; spherical indentation; sensitivity; condition number;
strain hardening
ID MEASURING ELASTOPLASTIC PROPERTIES; SENSING INSTRUMENTED INDENTATION;
ELASTIC-PLASTIC PROPERTIES; DUAL SHARP INDENTERS; CONICAL INDENTATION;
REPRESENTATIVE STRAIN; MECHANICAL-PROPERTIES; RESIDUAL-STRESS; METAL
MATERIALS; SENSITIVITY
AB Sensitivity to experimental errors determines the reliability and usefulness of any experimental investigation. Thus, it is important to understand how various test techniques are affected by expected experimental errors. Here, a semi-analytical method based on the concept of condition number is explored for systematic investigation of the sensitivity of spherical indentation to experimental errors. The method is employed to investigate the reliability of various possible spherical indentation protocols, providing a ranking of the selected data reduction protocols from least to most sensitive to experimental errors. Explicit Monte Carlo sensitivity analysis is employed to provide further insight of selected protocol, supporting the ranking. The results suggest that the proposed method for estimating the sensitivity to experimental errors is a useful tool. Moreover, in the case of spherical indentation, the experimental errors must be very small to give reliable material properties.
C1 [Phadikar, J. K.; Karlsson, A. M.] Univ Delaware, Dept Mech Engn, Newark, DE 19711 USA.
[Bogetti, T. A.] US Army Res Lab, Aberdeen, MD 21001 USA.
[Karlsson, A. M.] Cleveland State Univ, Washkewicz Coll Engn, Cleveland, OH 44115 USA.
RP Karlsson, AM (reprint author), Univ Delaware, Dept Mech Engn, Newark, DE 19711 USA.
EM jpha@udel.edu; travis.a.bogetti.civ@mail.mil; a.karlsson@csuohio.edu
FU Army Research Laboratory
FX The authors would like to thank Dr. Mark R. VanLandingham from Weapons
and Materials Research Directorate, Aberdeen Proving Ground, Aberdeen,
MD, for useful discussions. This research was sponsored by the Army
Research Laboratory and was accomplished under Cooperative Agreement No.
W911NF-06-2-011. The views and conclusions contained in this document
are those of the authors and should not be interpreted as representing
the official policies, either expressed or implied, of the Army Research
Laboratory or the U.S. Government.
NR 51
TC 0
Z9 0
U1 1
U2 13
PU ASME
PI NEW YORK
PA TWO PARK AVE, NEW YORK, NY 10016-5990 USA
SN 0094-4289
EI 1528-8889
J9 J ENG MATER-T ASME
JI J. Eng. Mater. Technol.-Trans. ASME
PD JUL
PY 2014
VL 136
IS 3
AR 031005
DI 10.1115/1.4027549
PG 8
WC Engineering, Mechanical; Materials Science, Multidisciplinary
SC Engineering; Materials Science
GA AJ7VN
UT WOS:000337908000005
ER
PT J
AU Cohen, EB
Moore, FR
Fischer, RA
AF Cohen, Emily B.
Moore, Frank R.
Fischer, Richard A.
TI Fuel stores, time of spring, and movement behavior influence stopover
duration of Red-eyed Vireo Vireo olivaceus
SO JOURNAL OF ORNITHOLOGY
LA English
DT Article
DE Nearctic-Neotropical migrant; Spring migration; Stopover duration;
Radio-telemetry; Red-eyed Vireo; Vireo olivaceus
ID GULF-OF-MEXICO; MIGRATION STOPOVER; NORTHERN WHEATEARS;
ERITHACUS-RUBECULA; OENANTHE-OENANTHE; EUROPEAN ROBINS; FAT DEPOSITION;
BIRD MIGRATION; DEPARTURES; MIGRANTS
AB Long-distance migration is characterized by periods of flight, when energy stores are consumed, and periods of stopover, when energy stores are replenished. The duration of the migratory period is largely determined by time spent at stopover sites. The time constraints imposed on spring migrants should act to minimize the time spent on migration, yet spring migrants often remain at stopover sites for extended periods. We measured the influence of arrival fuel stores, arrival date, and foraging movement rate on the duration of Red-eyed Vireos (Vireo olivaceus) that remained at stopover sites for more than 1 day. We captured spring migrants in mist-nets as they arrived after crossing the Gulf of Mexico. We released them at an inland site and continuously followed (radio-tracked) their movements until departure. Departure time was confirmed with extensive ground searches and aerial surveys. Migrants remained at the stopover sites from 1 to 8 days (2.80 +/- A 0.14 days). Less than one-third of migrants were transient, leaving the night following release (32 %). Of the migrants that remained more than 1 day, those that arrived with low fuel stores remained longer than those that arrived with more fuel stores. Only migrants arriving early in the spring stayed for extended periods of time (> 5 days). Further, migrants that moved faster within the stopover landscape presumably replenished fuel stores faster because they did not remain as long as migrants that did not move as quickly. When arrival fuel stores, arrival day, and departure day were known, we found multiple factors influenced the length of stay at spring stopover sites. Early spring migrants with low fuel stores that moved slowly through the landscape spent the most time at spring stopover sites.
C1 [Cohen, Emily B.; Moore, Frank R.] Univ So Mississippi, Dept Biol Sci, Hattiesburg, MS 39406 USA.
[Cohen, Emily B.] Smithsonian Conservat Biol Inst, Migratory Bird Ctr, Washington, DC 20013 USA.
[Fischer, Richard A.] US Army Engn Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA.
RP Cohen, EB (reprint author), Smithsonian Conservat Biol Inst, Migratory Bird Ctr, Natl Zool Pk,POB 37012,MRC 5503, Washington, DC 20013 USA.
EM cohene@si.edu
FU US Department of Defense Strategic Environmental Research and
Development Program; University of Southern Mississippi
FX Logistical support was provided by J. Johnson and D. Hudson at Fort Polk
and L. Bennett at Louisiana Wildlife and Fisheries. We would especially
like to thank the members of the migratory bird research group at USM
and all of the hard-working assistants who helped us collect data in the
field. Funding for this project was provided by the US Department of
Defense Strategic Environmental Research and Development Program and the
University of Southern Mississippi. This study was conducted in full
compliance with the laws of the United States of America.
NR 62
TC 5
Z9 5
U1 0
U2 29
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0021-8375
EI 1439-0361
J9 J ORNITHOL
JI J. Ornithol.
PD JUL
PY 2014
VL 155
IS 3
BP 785
EP 792
DI 10.1007/s10336-014-1067-3
PG 8
WC Ornithology
SC Zoology
GA AJ6HP
UT WOS:000337792500023
ER
PT J
AU Mayo, JB
Wetzel, ED
AF Mayo, J. B., Jr.
Wetzel, E. D.
TI Cut resistance and failure of high-performance single fibers
SO TEXTILE RESEARCH JOURNAL
LA English
DT Article
DE cut resistance; single fiber; cutting blade; aramid fiber; S-glass fiber
ID TRANSVERSE MECHANICAL-PROPERTIES; SHEAR THICKENING FLUID; BALLISTIC
IMPACT; STAB RESISTANCE; FABRICS; STRENGTH; BEHAVIOR; MODULUS; YARNS
AB The cut resistance of organic and inorganic high-performance single fibers has been studied. Several fiber types were examined, including Kevlar, Twaron, Vectran, Technora, Zylon, Dyneema, carbon fiber, and S-glass. Experiments were conducted using a custom-designed fixture that forces an industrial cutting blade laterally into a single fiber at varying blade and fiber angles. The effects of cutting angle and fiber type were explored, and the detailed progression of failure was inferred from post-failure imaging. All organic fibers demonstrated similar levels of cut resistance, with both organic and inorganic fibers showing less cut resistance as cutting angle is increased. Failure in the organic fibers was dominated by the anisotropic structure of the fibers. In contrast, isotropic, inorganic glass fibers demonstrated less cutting angle dependence and failed according to simple, localized brittle fracture. The inorganic fibers demonstrated higher average cut resistance than organic fibers, most likely due to their relative hardness and expected higher transverse mechanical properties.
C1 [Mayo, J. B., Jr.] Tuskegee Univ, Tuskgee Ctr Adv Mat, Tuskegee, AL 36088 USA.
[Mayo, J. B., Jr.; Wetzel, E. D.] US Army Res Lab, Mat & Mfg Sci Div, Adelphi, MD 20783 USA.
RP Wetzel, ED (reprint author), US Army Res Lab, Mat & Mfg Sci Div, Adelphi, MD 20783 USA.
EM eric.d.wetzel2.civ@mail.mil
FU Army Research Office, Battlefield Capability Enhancement Program
[W911NF-05-2-0006-P0006]
FX This work was supported by the Army Research Office, Battlefield
Capability Enhancement Program (grant number W911NF-05-2-0006-P0006).
NR 33
TC 4
Z9 5
U1 6
U2 35
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 0040-5175
EI 1746-7748
J9 TEXT RES J
JI Text. Res. J.
PD JUL
PY 2014
VL 84
IS 12
BP 1233
EP 1246
DI 10.1177/0040517513517966
PG 14
WC Materials Science, Textiles
SC Materials Science
GA AJ9GG
UT WOS:000338015100001
ER
PT J
AU Work, D
Tong, O
Workman, R
Katz, A
Wissink, AM
AF Work, Dalon
Tong, Oisin
Workman, Ryan
Katz, Aaron
Wissink, Andrew M.
TI Strand-Grid-Solution Procedures for Sharp Corners
SO AIAA JOURNAL
LA English
DT Article
ID UNSTRUCTURED MESHES; GENERATION; ACCURACY; FLOWS
AB The strand/Cartesian-grid approach provides many advantages for complex moving-body-flow simulations, including fully automatic volume grid generation, highly scalable domain connectivity, and high-order accuracy. In this work, the authors evaluate methods of handling sharp corners with strand grids through combinations of strand vector smoothing, multiple strands emanating from a single surface node, and telescoping Cartesian refinement into corner regions of the near-body grid. A new discretization strategy is introduced to better tolerate mesh skewness induced by strand smoothing. These approaches are tested for unsteady, laminar, and high-Reynolds-number turbulent flows. For standard viscous high-aspect-ratio grids, smoothed strands with telescoping Cartesian refinement provide the most accurate results with the least complexity. Mesh discontinuities associated with the use of multiple strands at sharp corners produce more error than with smoothed strands. With both strand approachesvector smoothing and multiple strands - targeted Cartesian refinement is critical to capture features near sharp corners that strand grids alone are too coarse to capture.
C1 [Work, Dalon; Tong, Oisin; Workman, Ryan; Katz, Aaron] Utah State Univ, Dept Mech & Aerosp Engn, Logan, UT 84322 USA.
[Wissink, Andrew M.] US Army Aeroflightdynam Directorate, Moffett Field, CA 94035 USA.
RP Work, D (reprint author), Utah State Univ, Dept Mech & Aerosp Engn, Logan, UT 84322 USA.
RI Katz, Aaron/I-8244-2015
OI Katz, Aaron/0000-0003-2739-9384
FU U.S. Army Research Office Fluid Dynamics Program; U.S. Department of
Defense High Performance Computing Modernization Office Computational
Research and Engineering for Acquisition Tools and Environments program
FX The current work was performed with the support of the U.S. Army
Research Office Fluid Dynamics Program, directed by Frederick Ferguson,
as well as the U.S. Department of Defense High Performance Computing
Modernization Office Computational Research and Engineering for
Acquisition Tools and Environments program.
NR 39
TC 3
Z9 3
U1 1
U2 2
PU AMER INST AERONAUTICS ASTRONAUTICS
PI RESTON
PA 1801 ALEXANDER BELL DRIVE, STE 500, RESTON, VA 22091-4344 USA
SN 0001-1452
EI 1533-385X
J9 AIAA J
JI AIAA J.
PD JUL
PY 2014
VL 52
IS 7
BP 1528
EP 1541
DI 10.2514/1.J052607
PG 14
WC Engineering, Aerospace
SC Engineering
GA AJ5SK
UT WOS:000337747800016
ER
PT J
AU George, AA
Hixson, CD
Peckham, SJ
Tyler, D
Zelger, B
AF George, Alan A.
Hixson, Caleb D.
Peckham, Steven J.
Tyler, Donald
Zelger, Bernhard
TI A case of oral lichen sclerosus with gingival involvement and Borrelia
identification
SO HISTOPATHOLOGY
LA English
DT Letter
C1 [George, Alan A.; Hixson, Caleb D.; Peckham, Steven J.; Tyler, Donald] Brooke Army Med Ctr, Dept Pathol, Ft Sam Houston, TX 78234 USA.
[Zelger, Bernhard] Med Univ Innsbruck, Dept Dermatol & Venerol, A-6020 Innsbruck, Austria.
RP George, AA (reprint author), Brooke Army Med Ctr, Dept Pathol, Ft Sam Houston, TX 78234 USA.
NR 9
TC 0
Z9 0
U1 0
U2 3
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0309-0167
EI 1365-2559
J9 HISTOPATHOLOGY
JI Histopathology
PD JUL
PY 2014
VL 65
IS 1
BP 146
EP 148
DI 10.1111/his.12363
PG 4
WC Cell Biology; Pathology
SC Cell Biology; Pathology
GA AJ5BE
UT WOS:000337694700018
PM 24387701
ER
PT J
AU Tateosian, L
Mitasova, H
Thakur, S
Hardin, E
Russ, E
Blundell, B
AF Tateosian, Laura
Mitasova, Helena
Thakur, Sidharth
Hardin, Eric
Russ, Emily
Blundell, Bruce
TI Visualizations of coastal terrain time series
SO INFORMATION VISUALIZATION
LA English
DT Article
DE Visualization of time series; temporal visualization; geovisualization;
visual perception; visual exploration; visualize changes; geospatial
data; three-dimensional visualization; spatial data; visual exploration;
space-time cube; geographic information systems; LiDAR; time series;
terrain elevation; land surfaces; GIS GRASS
ID NORTH-CAROLINA; VISUAL ANALYTICS; LIDAR DATA; SPACE; CUBE
AB In coastal regions, water, wind, gravitation, vegetation, and human activity continuously alter landscape surfaces. Visualizations are important for understanding coastal landscape evolution and its driving processes. Visualizing change in highly dynamic coastal terrain poses a formidable challenge; the combination of natural and anthropogenic forces leads to cycles of retreat and recovery and complex morphology of landforms. In recent years, repeated high-resolution laser terrain scans have generated a time series of point cloud data that represent landscapes at snapshots in time, including the impacts of major storms. In this article, we build on existing approaches for visualizing spatial-temporal data to create a collection of perceptual visualizations to support coastal terrain evolution analysis. We extract terrain features and track their migration; we derive temporal summary maps and heat graphs that quantify the pattern of elevation change and sediment redistribution and use the space-time cube concept to create visualizations of terrain evolution. The space-time cube approach allows us to represent shoreline evolution as an isosurface extracted from a voxel model created by stacking time series of digital elevation models. We illustrate our approach on a series of Light Detection and Ranging surveys of sandy North Carolina barrier islands. Our results reveal terrain changes of shoreline and dune ridge migration, dune breaches and overwash, the formation of new dune ridges, and the construction and destruction of homes, changes which are due to erosion and accretion, hurricanes, and human activities. These events are all visualized within their geographic and temporal contexts.
C1 [Tateosian, Laura; Mitasova, Helena; Hardin, Eric; Russ, Emily] N Carolina State Univ, Raleigh, NC 27695 USA.
[Thakur, Sidharth] Renaissance Comp Inst, Chapel Hill, NC USA.
[Blundell, Bruce] US Army, Alexandria, VA USA.
RP Tateosian, L (reprint author), N Carolina State Univ, NCSU Campus Box 7106,890 Faucette Dr, Raleigh, NC 27695 USA.
EM lgtateos@ncsu.edu
OI Mitasova, Helena/0000-0002-6906-3398
FU Army Research Office [W911NF-09-1-0560]; RENCI
FX This work was supported in part by a grant W911NF-09-1-0560 from Army
Research Office. This work was also supported in part by RENCI.
NR 30
TC 1
Z9 3
U1 6
U2 58
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1473-8716
EI 1473-8724
J9 INFORM VISUAL
JI Inf. Vis.
PD JUL
PY 2014
VL 13
IS 3
SI SI
BP 266
EP 282
DI 10.1177/1473871613487086
PG 17
WC Computer Science, Software Engineering
SC Computer Science
GA AJ5GT
UT WOS:000337711400006
ER
PT J
AU Torres, IP
Pedro, JRP
Narayanan, SV
Nguyen, NM
Roseff, SD
Spiess, BD
AF Torres Filho, Ivo P.
Pedro, Jose Ricardo P.
Narayanan, Srinivasan V.
Nguyen, Nguyen M.
Roseff, Susan D.
Spiess, Bruce D.
TI Perfluorocarbon emulsion improves oxygen transport of normal and sickle
cell human blood in vitro
SO JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
LA English
DT Article
DE oxygen transport; perfluorocarbon emulsion; oxygen extraction ratio;
sickle cell disease; facilitated diffusion; cardiopulmonary bypass
ID INVITRO CAPILLARY SYSTEM; EXTRACORPOREAL-CIRCULATION; CARDIOPULMONARY
BYPASS; FLUOROCARBON EMULSIONS; HEMORRHAGIC-SHOCK; O-2 TRANSPORT;
DELIVERY; HEMOGLOBIN; ERYTHROCYTES; DISEASE
AB Perfluorocarbons (PFC) are compounds with high gas solubility that could help deliver O-2 to tissues and have been suggested as adjunct therapy to ischemia. Using a newly designed in vitro system, we tested the hypothesis that a third generation PFC emulsion (Oxycyte) increased O-2 transport of blood by measuring changes in O2 extraction ratio. The system included a computer-controlled pump and blood-gas exchange chambers to oxygenate and deoxygenate the blood from nine sickle cell disease (SCD) patients and five healthy donors. The flowing blood reached various levels of hemoglobin O-2 saturation and O-2 partial pressures (PO2), measured using a CO-oximeter and a blood gas analyzer. The mixtures were kept at physiological blood pressure and temperature, constant flow, normobaric conditions, and FiO2=0.30. After adding PFC, the measurements suggested an increase in the transport of O-2 and CO. Addition of PFC resulted in larger PO2 difference from 15 +/- 2 mmHg to 23 +/- 2 mmHg. Using normal blood and blood from SCD patients, the average O-2 extraction ratio (O2ER) after PFC was significantly higher than baseline. Addition of saline did not cause statistically significant changes. The data suggest increased (facilitated) O-2 transport by this PFC emulsion in both normal and SCD blood. (C) 2013 Wiley Periodicals, Inc.
C1 [Torres Filho, Ivo P.; Pedro, Jose Ricardo P.; Narayanan, Srinivasan V.; Nguyen, Nguyen M.] Virginia Commonwealth Univ, Virginia Commonwealth Univ Reanimat Engn Shock Ct, Dept Physiol & Biophys, Richmond, VA 23298 USA.
[Torres Filho, Ivo P.; Spiess, Bruce D.] Virginia Commonwealth Univ, Virginia Commonwealth Univ Reanimat Engn Shock Ct, Dept Emergency Med, Richmond, VA 23298 USA.
[Torres Filho, Ivo P.] US Army Inst Surg Res, San Antonio, TX 78234 USA.
[Roseff, Susan D.] Virginia Commonwealth Univ, Virginia Commonwealth Univ Reanimat Engn Shock Ct, Dept Pathol, Richmond, VA 23298 USA.
[Spiess, Bruce D.] Virginia Commonwealth Univ, Virginia Commonwealth Univ Reanimat Engn Shock Ct, Dept Anesthesiol, Richmond, VA 23298 USA.
RP Torres, IP (reprint author), Virginia Commonwealth Univ, Virginia Commonwealth Univ Reanimat Engn Shock Ct, Dept Physiol & Biophys, Med Coll Virginia Campus, Richmond, VA 23298 USA.
EM ivoptf@msn.com
FU Oxygen Biotherapeutics Inc., Virginia Commonwealth University;
Universidade do Estado do Rio de Janeiro (to Ivo Torres Filho)
FX Contract grant sponsor: Oxygen Biotherapeutics Inc., Virginia
Commonwealth University Contract grant sponsor: Universidade do Estado
do Rio de Janeiro (to Ivo Torres Filho)
NR 41
TC 1
Z9 1
U1 3
U2 17
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1549-3296
EI 1552-4965
J9 J BIOMED MATER RES A
JI J. Biomed. Mater. Res. Part A
PD JUL
PY 2014
VL 102
IS 7
BP 2105
EP 2115
DI 10.1002/jbm.a.34885
PG 11
WC Engineering, Biomedical; Materials Science, Biomaterials
SC Engineering; Materials Science
GA AJ3MJ
UT WOS:000337570400006
PM 23894124
ER
PT J
AU Whalley, MS
Takahashi, MD
Fletcher, JW
Moralez, E
Ott, CR
Olmstead, MG
Savage, JC
Goerzen, CL
Schulein, GJ
Burns, HN
Conrad, B
AF Whalley, Matthew S.
Takahashi, Marc D.
Fletcher, Jay W.
Moralez, Ernesto, III
Ott, Carl R.
Olmstead, Michael G.
Savage, James C.
Goerzen, Chad L.
Schulein, Gregory J.
Burns, Hoyt N.
Conrad, Bill
TI Autonomous Black Hawk in Flight: Obstacle Field Navigation and
Landing-site Selection on the RASCAL JUH-60A
SO JOURNAL OF FIELD ROBOTICS
LA English
DT Article
AB This paper describes the development and flight test of autonomous obstacle field navigation and safe landing area selection on the U. S. Army Aeroflightdynamics Directorate RASCAL JUH-60A research helicopter. Using laser detection and ranging (LADAR) as the primary terrain sensor, the autonomous flight system is able to avoid obstacles, including wires, and select safe landing sites. An autonomous integrated landing zone approach profile was developed and validated that integrates cruise flight, low-level terrain flight, and approach to a safe landing spot determined on the fly. Results are presented for a range of sites and conditions. Approximately 750 km of autonomous flight was performed, 230 km of which was at low altitude in mountainous terrain using the obstacle field navigation system. This is the first time a full-scale helicopter has been flown fully autonomously a significant distance in low-level flight over complex terrain, basing its planning solely on sensor data gathered from an onboard sensor. These flights demonstrate tight integration between terrain avoidance, control, and autonomous landing. (C) 2014 Wiley Periodicals, Inc.
C1 [Whalley, Matthew S.; Takahashi, Marc D.; Fletcher, Jay W.; Moralez, Ernesto, III; Ott, Carl R.; Olmstead, Michael G.] US Army, Aviat Dev Directorate AFDD Aviat & Missile Res De, Dev & Engn Command, Moffett Field, CA 94035 USA.
[Savage, James C.] US Air Force, Res Lab, Weap Seeker Sci Branch AFRL RWWS, Eglin AFB, FL 32542 USA.
[Goerzen, Chad L.; Schulein, Gregory J.] San Jose State Univ, Ames Res Ctr, Moffett Field, CA 94035 USA.
[Burns, Hoyt N.; Conrad, Bill] HN Burns Engn Corp, Orlando, FL 32826 USA.
RP Goerzen, CL (reprint author), San Jose State Univ, Ames Res Ctr, Moffett Field, CA 94035 USA.
EM chad.l.goerzen.ctr@mail.mil
NR 31
TC 3
Z9 3
U1 3
U2 10
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1556-4959
EI 1556-4967
J9 J FIELD ROBOT
JI J. Field Robot.
PD JUL-AUG
PY 2014
VL 31
IS 4
SI SI
BP 591
EP 616
DI 10.1002/rob.21511
PG 26
WC Robotics
SC Robotics
GA AJ4WI
UT WOS:000337679200007
ER
PT J
AU Belenkiy, SM
Berry, JS
Batchinsky, AI
Kendrick, C
Necsoiu, C
Jordan, BS
Salinas, J
Cancio, LC
AF Belenkiy, Slava M.
Berry, John S.
Batchinsky, Andriy I.
Kendrick, Chonna
Necsoiu, Corina
Jordan, Bryan S.
Salinas, Jose
Cancio, Leopoldo C.
TI THE NONINVASIVE CARBON DIOXIDE GRADIENT (NICO(2)G) DURING HEMORRHAGIC
SHOCK
SO SHOCK
LA English
DT Article
DE Transcutaneous carbon dioxide; end-tidal carbon dioxide; noninvasive
carbon dioxide gradient; blood gas analysis; hemorrhage; swine
ID END-TIDAL CO2; CRITICALLY-ILL; CARDIOPULMONARY-RESUSCITATION;
TRANSCUTANEOUS OXYGEN; GENERAL-ANESTHESIA; CIRCULATORY SHOCK; TISSUE
HYPOXIA; ARTERIAL PCO2; SERUM LACTATE; CAPNOGRAPHY
AB Hemorrhagic shock (HS) is a setting in which both pulmonary and cutaneous perfusion may be impaired. The goals of this study were to evaluate the relationship between end-tidal (etCO(2)), transcutaneous (tPCO(2)), arterial carbon dioxide (PaCO2) and lactate during lethal HS and to assess the effect of progressive HS on those variables and on a new variable, the noninvasive CO2 gradient ([NICO(2)G] or the difference between tPCO(2) and etCO(2)). Ten consciously sedated swine were hemorrhaged, by means of a computerized exponential protocol, of up to 80% estimated blood volume for 20 min. End-tidal carbon dioxide, tPCO(2), PaCO2, and lactate measurements were taken at baseline and every 5 min thereafter, that is, after 25%, 44%, and 62% total blood volume hemorrhage (TBVH) and at cardiac arrest. Cardiac arrest occurred on average at 67% TBVH. Data were analyzed by linear regression and one-way repeated-measures analysis of variance and are presented as means +/- SD. Forty-nine paired measurements were made. There was no overall relationship between NICO2 variables and PaCO2: PaCO2 vs. tPCO(2) (r(2) = 0.002, P = 0.78); PaCO2 vs. etCO(2) (r(2) = 0.0002, P = 0.93). Rather, NICO(2)G increased at each level of blood loss: 4.0 +/- 24.9 at baseline, 6.3 +/- 35.7 at 25% TBVH, 25.0 +/- 37.6 at 44% TBVH, 55.0 +/- 33.9 at 62% TBVH, and 70.0 +/- 33.2 at cardiac arrest (P < 0.05). Similarly, tPCO(2) increased and etCO(2) decreased at each level. Linear regression of NICO(2)G and lactate showed a better correlation than was observed for the other two variables: NICO(2)G, r(2) = 0.58; tPCO(2), r(2) = 0.46; etCO(2), r(2) = 0.26. During HS, NICO2 monitors lose accuracy for approximating the PaCO2 but gain usefulness as hemodynamic monitors. Also, by combining data from two different organ systems, NICO(2)G demonstrated improved correlation with lactate than did either etCO(2) or tPCO(2) alone.
C1 [Belenkiy, Slava M.; Berry, John S.; Batchinsky, Andriy I.; Kendrick, Chonna; Necsoiu, Corina; Jordan, Bryan S.; Salinas, Jose; Cancio, Leopoldo C.] US Army Inst Surg Res, Ft Sam Houston, TX 78234 USA.
[Berry, John S.; Kendrick, Chonna] San Antonio Mil Med Ctr, Ft Sam Houston, TX USA.
RP Belenkiy, SM (reprint author), US Army Inst Surg Res, JBSA, 3650 Chambers Pass, Ft Sam Houston, TX 78234 USA.
EM slava.m.belenkiy.vol@mail.mil
FU Oridion, Inc.; US Army Institute of Surgical Research; Combat Critical
Care Engineering Task Area, Combat Casualty Care Research Area
Directorate, US Army Medical Research and Materiel Command
FX This study was supported by Oridion, Inc., under a Cooperative Research
and Development Agreement with the US Army Institute of Surgical
Research. This study was funded by the Combat Critical Care Engineering
Task Area, Combat Casualty Care Research Area Directorate, US Army
Medical Research and Materiel Command.
NR 34
TC 3
Z9 3
U1 0
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1073-2322
EI 1540-0514
J9 SHOCK
JI Shock
PD JUL
PY 2014
VL 42
IS 1
BP 38
EP 43
DI 10.1097/SHK.0000000000000177
PG 6
WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease
SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System
& Cardiology
GA AJ5CZ
UT WOS:000337700600008
PM 24667626
ER
PT J
AU Soller, B
Smith, C
Zou, F
Ellerby, GEC
Prince, MD
Sondeen, JL
AF Soller, Babs
Smith, Charles
Zou, Fengmei
Ellerby, Gwenn E. C.
Prince, M. Dale
Sondeen, Jill L.
TI INVESTIGATION OF NONINVASIVE MUSCLE PH AND OXYGEN SATURATION DURING
UNCONTROLLED HEMORRHAGE AND RESUSCITATION IN SWINE
SO SHOCK
LA English
DT Article
DE Hemorrhage; fluid resuscitation; NIRS; noninvasive monitoring; acidosis;
oxygen debt
ID NEAR-INFRARED SPECTROSCOPY; INITIAL RESUSCITATION; COMBAT CASUALTY;
SHOCK; OUTCOMES; MODEL
AB This study evaluated noninvasively determined muscle pH (pHm) and muscle oxygen saturation (SmO2) in a swine shock model that used uncontrolled hemorrhage and restricted volume resuscitation. Anesthetized 40-kg female swine underwent hemorrhage until 24 mL/kg of blood was removed (n = 26), followed by transection of the spleen, causing uncontrolled hemorrhage throughout the remainder of the protocol. After 15 min, 15 mL/kg of resuscitation fluid (Hextend, fresh-frozen plasma or platelets) was given for 30 min. Arterial and venous blood gases were measured at baseline, shock, end of resuscitation, and end of the study (death or 5 h), along with lactate and base excess. In addition, seven animals underwent a sham procedure. Spectra were collected continuously from the posterior thigh using a prototype CareGuide 1100 Oximeter, and pHm and SmO2 were calculated from the spectra. A two-factor analysis of variance with repeated measures followed by Tukey post hoc comparisons was used to compare experimental factors. It was shown that, for both pH and SO2, venous and muscle values were similar to each other at the end of the resuscitation period and at the end of the study for both surviving and nonsurviving animals. pH and SO2, venous and muscle, significantly declined as a result of bleeding, but lactate and base excess did not show significant changes during this period. Noninvasive pHm and SmO2 tracked the adequacy of resuscitation in real time, indicating at the time all of the fluid was delivered, which animals would live and which would die. The results of this swine study indicate that further evaluation on trauma patients is warranted.
C1 [Soller, Babs; Smith, Charles; Zou, Fengmei; Ellerby, Gwenn E. C.] Reflectance Med Inc, Westborough, MA 01581 USA.
[Prince, M. Dale; Sondeen, Jill L.] US Army Inst Surg Res, San Antonio, TX USA.
RP Soller, B (reprint author), Reflectance Med Inc, 116 Flanders Rd,Suite 1000, Westborough, MA 01581 USA.
EM babs.soller@reflectancemedical.com
FU US Army Medical Research and Materiel Command (USAMRMC)
[W81XWH-11-C-0001]; USAMRMC; Defense Medical Research and Development
Program
FX This study was supported by the US Army Medical Research and Materiel
Command (USAMRMC) (contract no. W81XWH-11-C-0001), by the USAMRMC Core
Funds, and by the Defense Medical Research and Development Program. The
views, opinions, and/or findings contained in this report are those of
the author(s) and should not be construed as an official Department of
the Army position, policy, or decision unless so designated by other
documentation.
NR 19
TC 2
Z9 2
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1073-2322
EI 1540-0514
J9 SHOCK
JI Shock
PD JUL
PY 2014
VL 42
IS 1
BP 44
EP 51
DI 10.1097/SHK.0000000000000174
PG 8
WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease
SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System
& Cardiology
GA AJ5CZ
UT WOS:000337700600009
PM 24667624
ER
PT J
AU Wang, GX
Murphy, D
Oller, A
Howard, HR
Anderson, AB
Rijal, S
Myers, NR
Woodford, P
AF Wang, Guangxing
Murphy, Dana
Oller, Adam
Howard, Heidi R.
Anderson, Alan B.
Rijal, Santosh
Myers, Natalie R.
Woodford, Philip
TI Spatial and Temporal Assessment of Cumulative Disturbance Impacts Due to
Military Training, Burning, Haying, and Their Interactions on Land
Condition of Fort Riley
SO ENVIRONMENTAL MANAGEMENT
LA English
DT Article
DE Cumulative impacts; Installation; Land condition; Military training;
Other human activities; Spatial and temporal assessment; Remote sensing
ID LONG-TERM DISTURBANCE; MANEUVER DISTURBANCE; TALLGRASS PRAIRIE; TRACKED
VEHICLES; PREDICT PATTERNS; MIXED PRAIRIE; SOIL; METHODOLOGY;
VEGETATION; INSTALLATIONS
AB The effects of military training activities on the land condition of Army installations vary spatially and temporally. Training activities observably degrade land condition while also increasing biodiversity and stabilizing ecosystems. Moreover, other anthropogenic activities regularly occur on military lands such as prescribed burns and agricultural haying-adding to the dynamics of land condition. Thus, spatially and temporally assessing the impacts of military training, prescribed burning, agricultural haying, and their interactions is critical to the management of military lands. In this study, the spatial distributions and patterns of military training-induced disturbance frequency were derived using plot observation and point observation-based method, at Fort Riley, Kansas from 1989 to 2001. Moreover, spatial and variance analysis of cumulative impacts due to military training, burning, haying, and their interactions on the land condition of Fort Riley were conducted. The results showed that: (1) low disturbance intensity dominated the majority of the study area with exception of concentrated training within centralized areas; (2) high and low values of disturbance frequency were spatially clustered and had spatial patterns that differed significantly from a random distribution; and (3) interactions between prescribed burning and agricultural haying were not significant in terms of either soil erosion or disturbance intensity although their means and variances differed significantly between the burned and non-burned areas and between the hayed and non-hayed areas.
C1 [Wang, Guangxing; Murphy, Dana; Oller, Adam; Rijal, Santosh] So Illinois Univ, Dept Geog & Environm Resources, Carbondale, IL 62901 USA.
[Howard, Heidi R.; Anderson, Alan B.; Myers, Natalie R.] ERDC CERL, Champaign, IL 61822 USA.
[Woodford, Philip] US Army, ATTN AFZN GT RD, Ft Riley, KS USA.
RP Wang, GX (reprint author), So Illinois Univ, Dept Geog & Environm Resources, Faner Hall 4520,1000 Faner Dr, Carbondale, IL 62901 USA.
EM gxwang@siu.edu
FU US Army Corps of Engineers, Construction Engineering Research Laboratory
(USA-CERL) [CERL W9132T-08-2-0019-Modification P00003]
FX We are grateful to US Army Corps of Engineers, Construction Engineering
Research Laboratory (USA-CERL) for providing support (CERL
W9132T-08-2-0019-Modification P00003) and data sets for this study and
also to the editors and reviewers.
NR 45
TC 2
Z9 2
U1 2
U2 14
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0364-152X
EI 1432-1009
J9 ENVIRON MANAGE
JI Environ. Manage.
PD JUL
PY 2014
VL 54
IS 1
BP 51
EP 66
DI 10.1007/s00267-014-0284-0
PG 16
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA AI9UP
UT WOS:000337285900006
PM 24817335
ER
PT J
AU Hannah, ST
Sumanth, JJ
Lester, P
Cavarretta, F
AF Hannah, Sean T.
Sumanth, John J.
Lester, Paul
Cavarretta, Fabrice
TI Debunking the false dichotomy of leadership idealism and pragmatism:
Critical evaluation and support of newer genre leadership theories
SO JOURNAL OF ORGANIZATIONAL BEHAVIOR
LA English
DT Review
DE leadership; transformational; ethical; authentic; servant; spiritual;
moral; performative
ID TRANSFORMATIONAL LEADERSHIP; ETHICAL LEADERSHIP; AUTHENTIC LEADERSHIP;
BEHAVIORAL INTEGRITY; METAANALYTIC TEST; FIELD EXPERIMENT; RESEARCH
AGENDA; MULTIDIMENSIONAL MEASURE; ORGANIZATIONAL-BEHAVIOR; SPIRITUAL
LEADERSHIP
AB Leadership theories have shifted over the last few decades from a focus on managerial functions and economic leader-follower exchanges toward greater focus on the interpersonal dynamics occurring within the leadership process. Theories such as transformational, ethical, authentic, and other newer genre theories were created to address neglected topics such as leader vision and inspirational messages, transparency, emotional effects, morality, individualized attention, and intellectual stimulation. Critiques of these theories, however, have been raised. In this paper, we address five of those critiques and argue for the validity and practical effectiveness of the new genre theories. Further, we describe how newer genre leadership research should be viewed as a performative epistemology, entailing a process of co-creation involving scholars and practitioners. Finally, from this view, we provide general ideas for leader development. Copyright (c) 2014 John Wiley & Sons, Ltd.
C1 [Hannah, Sean T.; Sumanth, John J.] Wake Forest Univ, Winston Salem, NC 27109 USA.
[Lester, Paul] US Army, Res Facilitat Team, Off Deputy Secretary Army, Monterey, CA USA.
[Cavarretta, Fabrice] ESSEC Business Sch, Paris, France.
RP Sumanth, JJ (reprint author), Wake Forest Univ, Sch Business, Suite 388,Farrell Hall,Bldg 60, Winston Salem, NC 27109 USA.
EM sumanthj@wfu.edu
NR 148
TC 5
Z9 5
U1 17
U2 98
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0894-3796
EI 1099-1379
J9 J ORGAN BEHAV
JI J. Organ. Behav.
PD JUL
PY 2014
VL 35
IS 5
BP 598
EP 621
DI 10.1002/job.1931
PG 24
WC Business; Psychology, Applied; Management
SC Business & Economics; Psychology
GA AJ4HT
UT WOS:000337636000002
ER
PT J
AU Han, ZY
Lu, JH
Liu, YL
Davis, B
Lee, MS
Olson, MA
Ruthel, G
Freedman, BD
Schnell, MJ
Wrobel, JE
Reitz, AB
Harty, RN
AF Han, Ziying
Lu, Jianhong
Liu, Yuliang
Davis, Benjamin
Lee, Michael S.
Olson, Mark A.
Ruthel, Gordon
Freedman, Bruce D.
Schnell, Matthias J.
Wrobel, Jay E.
Reitz, Allen B.
Harty, Ronald N.
TI Small-Molecule Probes Targeting the Viral PPxY-Host Nedd4 Interface
Block Egress of a Broad Range of RNA Viruses
SO JOURNAL OF VIROLOGY
LA English
DT Article
ID VESICULAR-STOMATITIS-VIRUS; PROTEIN-PROTEIN INTERACTIONS; LATE BUDDING
DOMAINS; ROUS-SARCOMA-VIRUS; EBOLA-VIRUS; MARBURG-VIRUS; MATRIX PROTEIN;
UBIQUITIN LIGASE; LASSA VIRUS; WW DOMAINS
AB Budding of filoviruses, arenaviruses, and rhabdoviruses is facilitated by subversion of host proteins, such as Nedd4 E3 ubiquitin ligase, by viral PPxY late (L) budding domains expressed within the matrix proteins of these RNA viruses. As L domains are important for budding and are highly conserved in a wide array of RNA viruses, they represent potential broad-spectrum targets for the development of antiviral drugs. To identify potential competitive blockers, we used the known Nedd4 WW domain-PPxY interaction interface as the basis of an in silico screen. Using PPxY-dependent budding of Marburg (MARV) VP40 virus-like particles (VLPs) as our model system, we identified small-molecule hit 1 that inhibited Nedd4-PPxY interaction and PPxY-dependent budding. This lead candidate was subsequently improved with additional structure-activity relationship (SAR) analog testing which enhanced antibudding activity into the nanomolar range. Current lead compounds 4 and 5 exhibit on-target effects by specifically blocking the MARV VP40 PPxY-host Nedd4 interaction and subsequent PPxY-dependent egress of MARV VP40 VLPs. In addition, lead compounds 4 and 5 exhibited antibudding activity against Ebola and Lassa fever VLPs, as well as vesicular stomatitis and rabies viruses (VSV and RABV, respectively). These data provide target validation and suggest that inhibition of the PPxY-Nedd4 interaction can serve as the basis for the development of a novel class of broad-spectrum, host-oriented antivirals targeting viruses that depend on a functional PPxY L domain for efficient egress.
C1 [Han, Ziying; Lu, Jianhong; Liu, Yuliang; Ruthel, Gordon; Freedman, Bruce D.; Harty, Ronald N.] Univ Penn, Sch Vet Med, Dept Pathobiol, Philadelphia, PA 19104 USA.
[Davis, Benjamin; Schnell, Matthias J.] Thomas Jefferson Univ, Dept Microbiol & Immunol, Philadelphia, PA 19107 USA.
[Lee, Michael S.; Olson, Mark A.] US Army Med Res Inst Infect Dis, Integrated Toxicol Div, Ft Detrick, MD USA.
[Lee, Michael S.] US Army Res Lab, Simulat Sci Branch, Aberdeen Proving Ground, MD USA.
[Wrobel, Jay E.; Reitz, Allen B.] Fox Chase Chem Div Ctr Inc, Doylestown, PA USA.
RP Harty, RN (reprint author), Univ Penn, Sch Vet Med, Dept Pathobiol, Philadelphia, PA 19104 USA.
EM rharty@vet.upenn.edu
FU NIH/NIAID [AI102104, U54-AI057168]
FX This work was supported in part by NIH/NIAID grants AI102104 and
U54-AI057168 to R.N.H.
NR 88
TC 22
Z9 25
U1 1
U2 28
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0022-538X
EI 1098-5514
J9 J VIROL
JI J. Virol.
PD JUL
PY 2014
VL 88
IS 13
BP 7294
EP 7306
DI 10.1128/JVI.00591-14
PG 13
WC Virology
SC Virology
GA AI9GN
UT WOS:000337240700017
PM 24741084
ER
PT J
AU Schieffer, M
Jessen, HK
Oster, AF
Pissani, F
Soghoian, DZ
Lu, R
Jessen, AB
Zedlack, C
Schultz, BT
Davis, I
Ranasinghe, S
Rosenberg, ES
Alter, G
Schumann, RR
Streeck, H
AF Schieffer, Miriam
Jessen, Heiko K.
Oster, Alexander F.
Pissani, Franco
Soghoian, Damien Z.
Lu, Richard
Jessen, Arne B.
Zedlack, Carmen
Schultz, Bruce T.
Davis, Isaiah
Ranasinghe, Srinika
Rosenberg, Eric S.
Alter, Galit
Schumann, Ralf R.
Streeck, Hendrik
TI Induction of Gag-Specific CD4 T Cell Responses during Acute HIV
Infection Is Associated with Improved Viral Control
SO JOURNAL OF VIROLOGY
LA English
DT Article
ID IN-VIVO; VIRUS; SUPERINFECTION; MAINTENANCE; PROTECTION; INFLUENZA;
KINETICS; DISEASE; VIREMIA
AB Effector CD4 T cell responses have been shown to be critically involved in the containment and clearance of viral pathogens. However, their involvement in the pathogenesis of HIV infection is less clear, given their additional role as preferred viral targets. We previously demonstrated that the presence of HIV-specific CD4 T cell responses is somewhat associated with HIV control and that specific CD4 T cell functions, such as direct cytolytic activity, can contribute to control of HIV viremia. However, little is known about how the induction of HIV-specific CD4 T cell responses during acute HIV infection influences disease progression and whether responses induced during the early phase of infection are preferentially depleted. We therefore longitudinally assessed, in a cohort of 55 acutely HIV-infected individuals, HIV-specific CD4 T cell responses from acute to chronic infection. Interestingly, we found that the breadth, magnitude, and protein dominance of HIV-specific CD4 T cell responses remained remarkably stable over time. Moreover, we found that the epitopes targeted at a high frequency in acute HIV infection were recognized at the same frequency by HIV-specific CD4 T cells in chronic HIV infection. Interestingly the induction of Gag-specific CD4 T cell responses in acute HIV infection was significantly inversely correlated with viral set point in chronic HIV infection (R = -0.5; P = 0.03), while the cumulative contribution of Env-specific CD4 T cell responses showed the reverse effect. Moreover, individuals with HIV-specific CD4 T cell responses dominantly targeting Gag over Env in acute HIV infection remained off antiretroviral therapy significantly longer (P = 0.03; log rank). Thus, our data suggest that the induction of HIV-specific CD4 T cell responses during acute HIV infection is beneficial overall and does not fuel disease progression.
C1 [Schieffer, Miriam; Jessen, Heiko K.; Jessen, Arne B.; Zedlack, Carmen; Davis, Isaiah] HIV Clin Praxis Jessen, Berlin, Germany.
[Oster, Alexander F.; Pissani, Franco; Lu, Richard; Schultz, Bruce T.; Streeck, Hendrik] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD 20910 USA.
[Oster, Alexander F.; Pissani, Franco; Lu, Richard; Schultz, Bruce T.; Streeck, Hendrik] Henry M Jackson Fdn Adv Mil Med, Bethesda, MD USA.
[Soghoian, Damien Z.; Ranasinghe, Srinika; Alter, Galit; Streeck, Hendrik] MIT, Ragon Inst MGH, Cambridge, MA 02139 USA.
[Soghoian, Damien Z.; Ranasinghe, Srinika; Alter, Galit; Streeck, Hendrik] Harvard Univ, Cambridge, MA 02138 USA.
[Rosenberg, Eric S.] Massachussetts Gen Hosp, Boston, MA USA.
[Schieffer, Miriam; Schumann, Ralf R.] Charite Univ Med Ctr, Inst Microbiol & Hyg, Berlin, Germany.
RP Streeck, H (reprint author), Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD 20910 USA.
EM hstreeck@hivresearch.org
FU U.S. National Institutes of Health (NIH) [R01 AI091450-01, R01
AI094602-01, P01 AI074415]; Bill and Melinda Gates Foundation
FX This study was funded by the U.S. National Institutes of Health (NIH)
(R01 AI091450-01, R01 AI094602-01, and P01 AI074415) and supported by
the Bill and Melinda Gates Foundation.
NR 36
TC 9
Z9 9
U1 0
U2 5
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0022-538X
EI 1098-5514
J9 J VIROL
JI J. Virol.
PD JUL
PY 2014
VL 88
IS 13
BP 7357
EP 7366
DI 10.1128/JVI.00728-14
PG 10
WC Virology
SC Virology
GA AI9GN
UT WOS:000337240700022
PM 24741089
ER
PT J
AU Cordero, ZC
Huskins, EL
Park, M
Livers, S
Frary, M
Schuster, BE
Schuh, CA
AF Cordero, Zachary C.
Huskins, Emily L.
Park, Mansoo
Livers, Steven
Frary, Megan
Schuster, Brian E.
Schuh, Christopher A.
TI Powder-Route Synthesis and Mechanical Testing of Ultrafine Grain
Tungsten Alloys
SO METALLURGICAL AND MATERIALS TRANSACTIONS A-PHYSICAL METALLURGY AND
MATERIALS SCIENCE
LA English
DT Article
ID PLASMA PRESSURE COMPACTION; NI-W ALLOYS; REFRACTORY-METALS; HIGH-STRAIN;
NANOCRYSTALLINE; SIZE; BEHAVIOR; HARDNESS; COMPRESSION; DRAWN
AB We report a W-rich alloy (W-7Cr-9Fe, at. pct) produced by high-energy ball milling, with alloying additions that both lower the densification temperature and retard grain growth. The alloy's consolidation behavior and the resultant compacts' microstructure and mechanical properties are explored. Under one condition, a 98 pct dense compact with a mean grain size of 130 nm was achieved, and exhibited a hardness of 13.5 GPa, a dynamic uniaxial yield strength of 4.14 GPa in Kolsky bar experiments, and signs of structural shear localization during deformation.
C1 [Cordero, Zachary C.; Park, Mansoo; Schuh, Christopher A.] MIT, Dept Mat Sci & Engn, Cambridge, MA 02139 USA.
[Huskins, Emily L.] Army Res Lab, Oak Ridge Inst Sci & Educ, Postdoctoral Fellowship Program, Aberdeen Proving Ground, MD 21005 USA.
[Livers, Steven; Frary, Megan] Boise State Univ, Dept Mat Sci & Engn, Boise, ID 83725 USA.
[Schuster, Brian E.] Army Res Laboratory, Expt & Computat Penetrat Mech Team, Weap & Mat Res Directorate, Adelphi, MD USA.
RP Cordero, ZC (reprint author), MIT, Dept Mat Sci & Engn, Cambridge, MA 02139 USA.
EM schuh@mit.edu
FU US Defense Threat Reduction Agency [HDTRA1-11-1-0062]; Department of
Defense through the NDSEG fellowship program; US Army Research
Laboratory through the Oak Ridge Institute for Space and Education
(ORISE) Program [1120-1120-99]; [11-24]
FX This study was supported by the US Defense Threat Reduction Agency under
Grant No. HDTRA1-11-1-0062. ZCC acknowledges support from the Department
of Defense through the NDSEG fellowship program. ELH acknowledges
support from the US Army Research Laboratory through the Oak Ridge
Institute for Space and Education (ORISE) Program # 1120-1120-99. BES
would like to acknowledge support work from the Cooperative Research and
Development Agreement #11-24. We would like to thank Ms. Alexandria
Will-Cole for her indentation work on the intermetallic phase, Dr. Kisub
Cho for performing the THERMOCALC calculations, and Dr. Daniel T. Casem
for his assistance with the Kolsky bar tests.
NR 58
TC 3
Z9 3
U1 5
U2 33
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1073-5623
EI 1543-1940
J9 METALL MATER TRANS A
JI Metall. Mater. Trans. A-Phys. Metall. Mater. Sci.
PD JUL
PY 2014
VL 45A
IS 8
BP 3609
EP 3618
DI 10.1007/s11661-014-2286-1
PG 10
WC Materials Science, Multidisciplinary; Metallurgy & Metallurgical
Engineering
SC Materials Science; Metallurgy & Metallurgical Engineering
GA AI7MX
UT WOS:000337076900043
ER
PT J
AU Willey, LN
Netherland, MD
Haller, WT
Langeland, KA
AF Willey, Leif N.
Netherland, Michael D.
Haller, William T.
Langeland, Kenneth A.
TI Evaluation of aquatic herbicide activity against crested floating heart
SO JOURNAL OF AQUATIC PLANT MANAGEMENT
LA English
DT Article
DE endothall; foliar; imazapyr; imazamox; Nymphoides; subsurface
AB Crested floating heart [Nymphoides cristata (Roxb.) Kuntze] is a rapidly spreading invasive aquatic plant found in the southeastern United States. This plant exhibits a nymphaeid growth form producing dense mats of overlapping, floating leaves at the end of long stems in water up to 3 m in depth. To date, most operational strategies have relied on aquatic herbicides; however, results have been inconsistent and anecdotal. The objective of this research was to evaluate the majority of registered aquatic herbicides for activity against crested floating heart. A series of small-scale tank experiments was conducted to determine efficacy of the active ingredients: (2,4-dichlorophenoxy)acetic acid (2,4-D), [(3,5,6-trichloro-2-pyridinyl)oxy]acetic acid (triclopyr), 7-oxabicyclo[2.2.1]heptane-2,3-dicarboxylic acid (endothall), 6,7-dihydrodipyrido[1,2-alpha:2',1'-c]pyrazinediium ion (diquat), X,2-dichloro-544-(difluoromethyl)-4,5-dihydro-3-methyl-5-oxo-1H-1,2,4-triazol-1-yl]-4-fluorobenzenepropanoic acid (carfentrazone), 2-[7-fluoro-3,4-dihydro-3-oxo-4-(2-propanyl)-2H-1,4-benzoxazin-6-yl]-4,5,6,7-tetrahydro-1H-isoindole-1,3(2H)-dione (flumioxazin), 2,6-bis[(4,6-dimethoxy-2-pyrimidinyl)oxy]benzoic acid (bispyribac-sodium), N-(phosphonomethyl)glycine (glyphosate), 2-[4,5-dihydro-4-methyl-4-(1-methylethyl)-5-oxo-1H-imidazol-2-yl]-5-(methoxymethyl)-3-pyridinecarboxylic acid (imazamox), (+/-)-2-[4,5-dihydro-4-methyl-4-(1-methylethyl)-5-oxo-1H-imidazol- 2-yl]-3-pyridinecarboxylic acid (imazapyr), and 2-(2,2-difluoroethoxy)-N-(5,8-dimethoxy[1,2,4]triazolo[1,5-c]pyrimidin-2-yl)-6-(trifluoromethyl)benzenesulfonamide (penoxsulam) applied via foliar and subsurface applications. Herbicides were applied at concentrations near maximum and half-maximum label use rates in the late spring through summer on plants that had formed a surface canopy. The submersed treatments were evaluated at 24 and 96-h exposure periods. Harvest at 4 wk after treatment indicated that most of the herbicides were not active after either the 24 or 96-h exposure at the highest test rate. In contrast, the liquid subsurface treatments of endothall at 0.25 and 0.5 mg ae L-1 provided complete control after 24 and 96-h exposures, whereas diquat at 0.18 and 0.37 mg ai L-1 provided 91 to 95% control after a 96-h exposure. Endothall also provided 24 to 60% biomass reductions after granular applications of 3 mg ae L-1 for a 96-h exposure. Foliarapplied imazamox and imazapyr at 1.2 kg ai ha(-1) provided similar levels of control ranging from 81 to 83% control respectively. The other foliar-applied herbicides, including 2,4-D, triclopyr, and glyphosate, were not effective. For herbicides tested as both foliar and submersed applications, it was found that method of application had limited impact on activity and efficacy. Furthermore, aside from the amine salt of endothall, we did not detect a difference between liquid and granular formulations for submersed applications. These data indicate that most of the herbicides tested had limited activity on crested floating heart in our experimental system. These results suggest the amine salt of endothall and diquat as submersed applications and imazapyr and imazamox as foliar applications were the most effective. Further testing is needed to determine optimal timing, use rates, and products for efficacy under field conditions.
C1 [Willey, Leif N.; Haller, William T.; Langeland, Kenneth A.] Univ Florida, Inst Food & Agr Sci, Ctr Aquat & Invas Plants, Agron, Gainesville, FL 32653 USA.
[Netherland, Michael D.] US Army Engineer Res & Dev Ctr, Ctr Aquat & Invas Plants, Gainesville, FL 32653 USA.
RP Willey, LN (reprint author), Univ Florida, Inst Food & Agr Sci, Ctr Aquat & Invas Plants, Agron, 7922 NW 71st St, Gainesville, FL 32653 USA.
EM lwilley@ufl.edu
FU Florida Fish and Wildlife Commission; Midwest Aquatic Plant Management
Society; Aquatic Ecosystem Restoration Foundation
FX Funding for this project was provided by the Florida Fish and Wildlife
Commission, Invasive Plant Management section. Additional support was
provided to L.N.W. with a student research grant from the Midwest
Aquatic Plant Management Society and a grant from the Aquatic Ecosystem
Restoration Foundation provided to the University of Florida Center for
Aquatic and Invasive Plants to support graduate student projects. We
also thank G. Hoyer and Z. Banks for assisting with data collection and
maintaining plant stocks.
NR 27
TC 3
Z9 3
U1 0
U2 5
PU AQUATIC PLANT MANAGEMENT SOC, INC
PI VICKSBURG
PA PO BOX 821265, VICKSBURG, MS 39182 USA
SN 0146-6623
J9 J AQUAT PLANT MANAGE
JI J. Aquat. Plant Manage.
PD JUL
PY 2014
VL 52
BP 47
EP 56
PG 10
WC Plant Sciences; Marine & Freshwater Biology
SC Plant Sciences; Marine & Freshwater Biology
GA V41TD
UT WOS:000209567600003
ER
PT J
AU Netherland, MD
Glomski, LM
AF Netherland, Michael D.
Glomski, Leeann M.
TI Mesocosm evaluation of triclopyr on Eurasian watermilfoil and three
native submersed species: The role of treatment timing and herbicide
exposure
SO JOURNAL OF AQUATIC PLANT MANAGEMENT
LA English
DT Article
DE aquatic herbicides; invasive aquatic plants; SAV; Submersed Aquatic
Vegetation
AB Early-season recommendations to improve herbicide efficacy and selectivity when targeting Eurasian watermilfoil (Myriophyllum spicatum L.) have been adopted by many aquatic plant managers in the upper Midwest. To address the role of treatment timing and exposure, two mesocosm studies were conducted on plants established the prior fall to evaluate short- and long-term exposure scenarios when the auxin mimic herbicide triclopyr ([3,5,6-trichloro-2-pyridinyl)oxy]acetic acid) is used for selective control of Eurasian watermilfoil (EWM). The first study included liquid and granular triclopyr applied at 1.5 mg L-1 in late February and late April 2009 under high-water-exchange conditions (12-h half-life). The second trial included static liquid exposures for early March and late April 2011 treatments at use rates of 0.25, 0.5, and 1.5 mg L-1 and liquid and granular treatments at 1.5 mg L-1 under high-waterexchange conditions (5-h half-life). The second study also included the native species American pondweed (Potamogeton nodosus Poir.), Illinois pondweed (P. illinoensis Morong), and vallisneria (Vallisneria americana Michx.). In the first study, February triclopyr treatments with liquid and granular formulations did not reduce biomass compared to the untreated plants during a May harvest, whereas both April treatments resulted in complete control of EWM. Results of the second trial indicated that treatment timing (March vs. April) was not a significant factor for static treatments (0.25 to 1.5 mg L-1) and near 100% EWM control was achieved. In contrast, under high flow conditions, the March liquid treatment did not differ from the untreated reference plants. The granular treatment reduced EWM by 55% compared to the untreated reference, yet it still increased in biomass by 4-fold compared to the initial biomass. The April treatments were more effective than the March applications under conditions of high water exchange. The native plants evaluated were not impacted by treatment timing, rate, formulation, or exposure scenario. Results demonstrate early-season treatments were effective regardless of treatment timing under extended triclopyr exposure periods; however, in areas of high-water-exchange early treatments of EWM resulted in reduced plant control. Managers can use this information to determine if early- or later-season treatments are warranted based on the likely exposure scenario.
C1 [Netherland, Michael D.] US Army Engineer Res & Dev Ctr, Ctr Aquat & Invas Plants, Gainesville, FL 32653 USA.
[Glomski, Leeann M.] US Army Engineer Res & Dev Ctr, Lewisville Aquat Ecosyst Res Facil, Lewisville, TX 75057 USA.
RP Netherland, MD (reprint author), US Army Engineer Res & Dev Ctr, Ctr Aquat & Invas Plants, Gainesville, FL 32653 USA.
EM mdnether@ufl.edu
NR 21
TC 2
Z9 2
U1 2
U2 3
PU AQUATIC PLANT MANAGEMENT SOC, INC
PI VICKSBURG
PA PO BOX 821265, VICKSBURG, MS 39182 USA
SN 0146-6623
J9 J AQUAT PLANT MANAGE
JI J. Aquat. Plant Manage.
PD JUL
PY 2014
VL 52
BP 57
EP 64
PG 8
WC Plant Sciences; Marine & Freshwater Biology
SC Plant Sciences; Marine & Freshwater Biology
GA V41TD
UT WOS:000209567600004
ER
PT J
AU Mudge, CR
Netherland, MD
AF Mudge, Christopher R.
Netherland, M. D.
TI Response of giant bulrush, water hyacinth, and water lettuce to foliar
herbicide applications
SO JOURNAL OF AQUATIC PLANT MANAGEMENT
LA English
DT Article
DE 2,4-D; chemical control; diquat; Eichhornia crassipes; flumioxazin;
glyphosate; imazamox; penoxsulam; Pistia stratiotes; Schoenoplectus
californicus; selectivity; triclopyr
AB The aquatic herbicides 2,4-D (2,4-dichlorophenoxyacetic acid) and diquat (6,7-dihydrodipyrido [1,2-a : 2',1'-c]pyraziriediium ion) are commonly used to control the invasive floating plants water hyacinth (Eichhornia crassipes [Mart.] So lms) and water lettuce (Pistia stratiotes L.). Despite the high level of efficacy and rapid injury markers from these foliarapplied herbicides, nontarget injury is common when these herbicides are applied to mixed populations of target and nontarget emergent plant species. Therefore, a series of trials were conducted to find additional herbicides that can selectively control water hyacinth and water lettuce. Giant bulrush (hard-stem bulrush, Schoenoplectus californicus [C.A. Mey] Palla) shoot biomass was not reduced by the aquatic herbicides flumioxazin (2[7-fluoro-3,4-dihydro- 3-oxo-4-(2propynyl)-2H-1,4-benzoxazin-6-yl]-4,5,6,7-tetrahydro-1H- isoindole-1,3[2H]-dione), imazamox (2-[4,5-dihydro-4-methyl-4-(1-methylethyl)-5-oxo-1 H-imidazol-2-yl]-5- [methoxymethyl]-3-pyridinecarboxylic acid), and penoxsulam (2-[2,2-difluoroethoxy]-N-(5,8-dimethoxy [1,2,4]triazolo[1,5- c] pyrimidin-2-yl)-6-[trifluoromethyl] benzenesulfonamide) 8 wk after treatment (WAT). Conversely, 2,4-D, diquat, glyphosate (N-[phosphonomethyl]glycine), triclopyr (3,5,6- trichloro-2-pyridinyloxyacetic acid), and 2,4-D plus diquat reduced plant dry weight 49 to 97%. In the water hyacinth screening trial, all herbicide treatments except flumioxazin resulted in 76 to 100% control. Water lettuce dry weight was reduced >61% by all foliar herbicide treatments, with the exception of 2,4-D and triclopyr. Although imazamox and penoxsulam were efficacious against the target species, noticeable injury symptoms were slow to develop (1 to 2 wk to occur), and the acetolactate synthase (ALS) herbicides were much slower in controlling the plants compared to other efficacious herbicides evaluated in the screening trial. These results indicate imazamox and penoxsulam may be suitable for selectively managing water hyacinth and water lettuce.
C1 [Mudge, Christopher R.] Louisiana State Univ, Sch Plant Environm & Soil Sci, US Army Engineer Res & Dev Ctr, Baton Rouge, LA 70803 USA.
[Netherland, M. D.] US Army Engineer Res & Dev Ctr, Ctr Aquat & Invas Plants, Gainesville, FL 32653 USA.
RP Mudge, CR (reprint author), Louisiana State Univ, Sch Plant Environm & Soil Sci, US Army Engineer Res & Dev Ctr, Baton Rouge, LA 70803 USA.
EM Christopher.R.Mudge@usace.army.mil
FU U.S. Army Corps of Engineers Jacksonville District; U.S. Army Aquatic
Plant Control Research Program
FX This research was supported by the U.S. Army Corps of Engineers
Jacksonville District and the U.S. Army Aquatic Plant Control Research
Program. Jeremy Crossland and Michael Saucier kindly provided reviews of
this manuscript. Permission was granted by the Chief of Engineers to
publish this information. Citation of trade names does not constitute
endorsement or approval of the use of such commercial products.
NR 20
TC 0
Z9 0
U1 1
U2 2
PU AQUATIC PLANT MANAGEMENT SOC, INC
PI VICKSBURG
PA PO BOX 821265, VICKSBURG, MS 39182 USA
SN 0146-6623
J9 J AQUAT PLANT MANAGE
JI J. Aquat. Plant Manage.
PD JUL
PY 2014
VL 52
BP 75
EP 80
PG 6
WC Plant Sciences; Marine & Freshwater Biology
SC Plant Sciences; Marine & Freshwater Biology
GA V41TD
UT WOS:000209567600007
ER
PT J
AU Glomski, LM
Netherland, MD
AF Glomski, Leeann M.
Netherland, Michael D.
TI Response of waterlily, spatterdock, and hardstem bulrush to liquid and
granular triclopyr treatments
SO JOURNAL OF AQUATIC PLANT MANAGEMENT
LA English
DT Article
C1 [Glomski, Leeann M.] US Army Engineer Res & Dev Ctr, Lewisville Aquat Ecosyst Res Facil, Lewisville, TX 75057 USA.
[Netherland, Michael D.] US Army Engineer Res & Dev Ctr, Ctr Aquat & Invas Plants, Gainesville, FL 32653 USA.
RP Glomski, LM (reprint author), US Army Engineer Res & Dev Ctr, Lewisville Aquat Ecosyst Res Facil, 201 E Jones St, Lewisville, TX 75057 USA.
EM LeeAnn.M.Glomski@usace.army.mil
NR 12
TC 1
Z9 1
U1 2
U2 4
PU AQUATIC PLANT MANAGEMENT SOC, INC
PI VICKSBURG
PA PO BOX 821265, VICKSBURG, MS 39182 USA
SN 0146-6623
J9 J AQUAT PLANT MANAGE
JI J. Aquat. Plant Manage.
PD JUL
PY 2014
VL 52
BP 81
EP 84
PG 4
WC Plant Sciences; Marine & Freshwater Biology
SC Plant Sciences; Marine & Freshwater Biology
GA V41TD
UT WOS:000209567600008
ER
PT J
AU Wersal, RM
Poovey, AG
Madsen, JD
Getsinger, KD
Mudge, CR
AF Wersal, Ryan M.
Poovey, A. G.
Madsen, J. D.
Getsinger, K. D.
Mudge, C. R.
TI . Comparison of late-season herbicide treatments for control of emergent
flowering rush in mesocosms
SO JOURNAL OF AQUATIC PLANT MANAGEMENT
LA English
DT Article
C1 [Wersal, Ryan M.] Lonza, Alpharetta, GA 30004 USA.
[Poovey, A. G.; Getsinger, K. D.; Mudge, C. R.] US Army Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA.
[Wersal, Ryan M.; Madsen, J. D.] Geosyst Res Inst, Mississippi State, MS 39762 USA.
RP Wersal, RM (reprint author), Lonza, 1200 Bluegrass Lakes Pkwy, Alpharetta, GA 30004 USA.
EM ryan.wersal@lonza.com
NR 21
TC 2
Z9 2
U1 0
U2 3
PU AQUATIC PLANT MANAGEMENT SOC, INC
PI VICKSBURG
PA PO BOX 821265, VICKSBURG, MS 39182 USA
SN 0146-6623
J9 J AQUAT PLANT MANAGE
JI J. Aquat. Plant Manage.
PD JUL
PY 2014
VL 52
BP 85
EP 89
PG 5
WC Plant Sciences; Marine & Freshwater Biology
SC Plant Sciences; Marine & Freshwater Biology
GA V41TD
UT WOS:000209567600009
ER
PT J
AU Glomski, LM
Willey, LN
Netherland, MD
AF Glomski, Leeann M.
Willey, Leif N.
Netherland, Michael D.
TI The efficacy of protox-inhibiting herbicides alone and in combination
with glyphosate to control crested floating heart
SO JOURNAL OF AQUATIC PLANT MANAGEMENT
LA English
DT Article
C1 [Glomski, Leeann M.] US Army Engineer Res & Dev Ctr, Lewisville Aquat Ecosyst Res Facil, Lewisville, TX 75057 USA.
[Willey, Leif N.] Univ Florida, Gainesville, FL 32653 USA.
[Netherland, Michael D.] US Army Engineer Res & Dev Ctr, Ctr Aquat & Invas Plants, Gainesville, FL 32653 USA.
RP Glomski, LM (reprint author), US Army Engineer Res & Dev Ctr, Lewisville Aquat Ecosyst Res Facil, 201 E Jones St, Lewisville, TX 75057 USA.
EM LeeAnn.M.Glomski@usace.army.mil
FU Florida Fish and Wildlife Commission
FX Support for this research was provided by the Florida Fish and Wildlife
Commission, Invasive Plant Management Section. Citation of trade names
does not constitute an official endorsement or approval of the use of
such commercial products. Permission was granted by the Chief of
Engineers to publish this information.
NR 14
TC 3
Z9 3
U1 2
U2 3
PU AQUATIC PLANT MANAGEMENT SOC, INC
PI VICKSBURG
PA PO BOX 821265, VICKSBURG, MS 39182 USA
SN 0146-6623
J9 J AQUAT PLANT MANAGE
JI J. Aquat. Plant Manage.
PD JUL
PY 2014
VL 52
BP 90
EP 92
PG 3
WC Plant Sciences; Marine & Freshwater Biology
SC Plant Sciences; Marine & Freshwater Biology
GA V41TD
UT WOS:000209567600010
ER
PT J
AU Owens, CS
Smart, RM
Dick, GO
AF Owens, Chetta S.
Smart, R. Michael
Dick, Gary O.
TI Effects of salinity and pH on growth of giant salvinia (Salvinia molesta
Mitchell)
SO JOURNAL OF AQUATIC PLANT MANAGEMENT
LA English
DT Article
C1 [Owens, Chetta S.; Smart, R. Michael; Dick, Gary O.] USAE Lewisville Aquat Ecosyst Res Facil, Lewisville, TX 75057 USA.
RP Owens, CS (reprint author), USAE Lewisville Aquat Ecosyst Res Facil, 201 E Jones St, Lewisville, TX 75057 USA.
EM chetta@laerf.org
NR 28
TC 0
Z9 0
U1 1
U2 3
PU AQUATIC PLANT MANAGEMENT SOC, INC
PI VICKSBURG
PA PO BOX 821265, VICKSBURG, MS 39182 USA
SN 0146-6623
J9 J AQUAT PLANT MANAGE
JI J. Aquat. Plant Manage.
PD JUL
PY 2014
VL 52
BP 93
EP 96
PG 4
WC Plant Sciences; Marine & Freshwater Biology
SC Plant Sciences; Marine & Freshwater Biology
GA V41TD
UT WOS:000209567600011
ER
PT J
AU Ellis, BD
DiPaolo, BP
McDowell, DL
Zhou, M
AF Ellis, B. D.
DiPaolo, B. P.
McDowell, D. L.
Zhou, M.
TI Experimental investigation and multiscale modeling of
ultra-high-performance concrete panels subject to blast loading
SO INTERNATIONAL JOURNAL OF IMPACT ENGINEERING
LA English
DT Article
DE UHPC; Blast loading; Multiscale modeling
ID CEMENTITIOUS COMPOSITES; FIBER; STEEL; BEHAVIOR
AB Tailored cementitious materials, such as Ultra-High-Performance Concrete (UHPC), may significantly improve the blast resistance of structural panels. To understand and quantify the performance of UHPC panels subject to blast loading, four 1626- by 864- by 51-mm UHPC panels without steel rebar reinforcement were subjected to reflected impulse loads between 0.77 and 2.05 MPa-ms. The UHPC material was composed of a commercially available UHPC premix, high-range water reducing agent, 2% volume fraction of straight, smooth 14-mm-long by 0.185-mm-diameter fibers, and water. Experimental results determined that the UHPC panel fractured at a reflected impulse between 0.97 and 1.47 MPa-ms. These results were used to validate a multiscale model which accounts for structure and phenomena at two length scales: a multiple fiber length scale and a structural length scale. Within the multiscale model, a hand-shaking scheme conveys the energy barrier threshold and dissipated energy density from the model at the multiple fiber length scale to the model at the structural length scale. Together, the models at the two length scales account for energy dissipation through granular flow of the matrix, frictional pullout of the fibers, and friction between the interfaces. The simulated displacement and fracture patterns generated by the multiscale model are compared to experimental observations. This work is significant for three reasons: (1) new experimental data provide an upper and lower bound to the blast resistance of UHPC panels, (2) the multiscale model simulates the experimental results using readily available material properties and information regarding mesostructure attributes at two different length scales, and (3) by incorporating information from multiple length scales, the multiscale model can facilitate the design of UHPC materials to resist blast loading in ways not accessible using single length scale models. (C) 2014 Elsevier Ltd. All rights reserved.
C1 [Ellis, B. D.; McDowell, D. L.; Zhou, M.] Georgia Inst Technol, Woodruff Sch Mech Engn, Atlanta, GA 30332 USA.
[DiPaolo, B. P.] US Army, Engn Res & Dev Ctr, Vicksburg, MS 39180 USA.
[McDowell, D. L.; Zhou, M.] Georgia Inst Technol, Sch Mat Sci & Engn, Atlanta, GA 30332 USA.
RP Ellis, BD (reprint author), Georgia Inst Technol, Woodruff Sch Mech Engn, Atlanta, GA 30332 USA.
EM bellis7@gatech.edu
FU Department of Homeland Security; Science and Technology Directorate;
Infrastructure Protection and Disaster Management Division: Mila Kennett
FX This work was sponsored by the Department of Homeland Security, Science
and Technology Directorate, Infrastructure Protection and Disaster
Management Division: Mila Kennett, Program Manager. The research was
performed under the direction of Dr. Beverly P. DiPaolo, Engineer
Research and Development Center (ERDC), U.S. Army Corps of Engineers
(USACE). Permission to publish was granted by the Director, Geotechnical
and Structures Laboratory, ERDC. Approved for public release;
distribution is unlimited.
NR 26
TC 10
Z9 11
U1 3
U2 31
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0734-743X
EI 1879-3509
J9 INT J IMPACT ENG
JI Int. J. Impact Eng.
PD JUL
PY 2014
VL 69
BP 95
EP 103
DI 10.1016/j.ijimpeng.2013.12.011
PG 9
WC Engineering, Mechanical; Mechanics
SC Engineering; Mechanics
GA AH3FY
UT WOS:000336010300009
ER
PT J
AU Fox, DM
Akers, SA
Leiste, UH
Fourney, WL
Windham, JE
Lee, JS
Ehrgott, JQ
Taylor, LC
AF Fox, D. M.
Akers, S. A.
Leiste, U. H.
Fourney, W. L.
Windham, J. E.
Lee, J. S.
Ehrgott, J. Q.
Taylor, L. C.
TI The effects of air filled voids and water content on the momentum
transferred from a shallow buried explosive to a rigid target
SO INTERNATIONAL JOURNAL OF IMPACT ENGINEERING
LA English
DT Article
DE Mine blast; Soil mechanics; Shallow-buried explosive; Multi-component
flow; Momentum transfer
ID PARAMETERS
AB Small-scale dynamic experiments were performed using explosive charges shallow buried in water or in various soil types at differing initial states. Using the results from these experiments, it was discovered that the amount of momentum transferred to a rigid target is relatively independent of soil type but that mostly depends on the initial air-filled void content of the soil and the effect of water content on the yield strength of the soil.
Data from quasi-static tests of soils at a number of initial states along with known results for the higher pressure behavior of water-quartz mixtures were combined to construct soil models at various initial soil states. Computations were performed in order to evaluate the sensitivity of rigid plate loading to various facets of constitutive behavior described in the soil models in order to better understand the causes for the newly revealed parametric relationship. The computations closely matched the experimental results, thereby supporting theories regarding the parametric relations. The results from the computations offered insight into the mechanics behind the parametric relations. (C) 2014 Elsevier Ltd. All rights reserved.
C1 [Fox, D. M.] US Army, Res Lab, Blast Protect Branch, Aberdeen Proving Ground, MD 21005 USA.
[Fox, D. M.] Wayne State Univ, Dept Mech Engn, Detroit, MI 48202 USA.
[Akers, S. A.; Windham, J. E.; Ehrgott, J. Q.] US Army, Engn Res & Dev Ctr, Geotech & Struct Lab, Impact & Explos Effects Branch, Vicksburg, MS 39180 USA.
[Leiste, U. H.; Fourney, W. L.; Taylor, L. C.] Univ Maryland, Dept Mech Engn, College Pk, MD 20742 USA.
[Lee, J. S.] Yonsei Univ, Dept Mech Engn, Seoul 120749, South Korea.
RP Lee, JS (reprint author), Yonsei Univ, Dept Mech Engn, Seoul 120749, South Korea.
EM joonlee@yonsei.ac.kr
FU Ed Fioravante of the US Army Research Laboratory; Scott Schoenfeld;
Scott Kukuck; Neil Gniazdowski
FX We are grateful to Scott Schoenfeld, Scott Kukuck, Neil Gniazdowski and
Ed Fioravante of the US Army Research Laboratory for supporting this
work.
NR 36
TC 5
Z9 5
U1 0
U2 8
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0734-743X
EI 1879-3509
J9 INT J IMPACT ENG
JI Int. J. Impact Eng.
PD JUL
PY 2014
VL 69
BP 182
EP 193
DI 10.1016/j.ijimpeng.2014.02.019
PG 12
WC Engineering, Mechanical; Mechanics
SC Engineering; Mechanics
GA AH3FY
UT WOS:000336010300017
ER
PT J
AU Coleman, JG
Lotufo, GR
Kennedy, AJ
Poda, AR
Rushing, TS
Ruiz, CE
Bridges, TS
AF Coleman, Jessica G.
Lotufo, Guilhernie R.
Kennedy, Alan J.
Poda, Aimee R.
Rushing, Todd S.
Ruiz, Carlos E.
Bridges, Todd S.
TI Testing of various membranes for use in a novel sediment porewater
isolation chamber for infaunal invertebrate exposure to PCBs
SO CHEMOSPHERE
LA English
DT Article
DE Sediment; Porewater; Diffusion; Membrane; Bioavailability; Benthic
ID PASSIVE SAMPLER; PORE-WATER
AB In benthic sediment bioassays, determining the relative contribution to exposure by contaminants in overlying water, porewater, and sediment particles is technically challenging. The purpose of the present study was to assess the potential for membranes to be utilized as a mechanism to allow freely dissolved hydrophobic organic contaminants into a pathway isolation exposure chamber (PIC) while excluding all sediment particles and dissolved organic carbon (DOC). This investigation was conducted in support of a larger effort to assess contaminant exposure pathways to benthos. While multiple passive samplers exist for estimating concentrations of contaminants in porewater such as those using solid-phase micro extraction (SPME) and polyoxymethylene (POM), techniques to effectively isolate whole organism exposure to porewater within a sediment system are not available. We tested the use of four membranes of different pore sizes (0.1-1.2 mu m) including nylon, polycarbonate, polyethylsulfone, and polytetrafluoroethylene with a hydrophilic coating. Exposures included both diffusion of radiolabeled and non-labeled contaminants across membranes from aqueous, sediment slurry, and whole sediment sources to assess and evaluate the best candidate membrane. Data generated from the present study was utilized to select the most suitable membrane for use in the larger bioavailability project which sought to assess the relevance of functional ecology in bioavailability of contaminated sediments at remediation sites. The polytetrafluoroethylene membrane was selected for use in the PIC, although exclusion of dissolved organic carbon was not achieved.
C1 [Coleman, Jessica G.; Lotufo, Guilhernie R.; Kennedy, Alan J.; Poda, Aimee R.; Ruiz, Carlos E.; Bridges, Todd S.] US Army, Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA.
[Rushing, Todd S.] US Army, Engineer Res & Dev Ctr, Geotech Struct Lab, Vicksburg, MS 39180 USA.
RP Coleman, JG (reprint author), US Army, Engineer Res & Dev Ctr, Environm Lab, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA.
EM jessica.g.coleman@us.army.mil
RI Poda, Aimee/K-1905-2012
NR 10
TC 1
Z9 1
U1 3
U2 36
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0045-6535
EI 1879-1298
J9 CHEMOSPHERE
JI Chemosphere
PD JUL
PY 2014
VL 106
BP 65
EP 69
DI 10.1016/j.chemosphere.2014.01.062
PG 5
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA AE6VR
UT WOS:000334136600008
PM 24582361
ER
PT J
AU McAllister, QP
Strawhecker, KE
Becker, CR
Lundgren, CA
AF McAllister, Quinn P.
Strawhecker, Kenneth E.
Becker, Collin R.
Lundgren, Cynthia A.
TI In situ atomic force microscopy nanoindentation of lithiated silicon
nanopillars for lithium ion batteries
SO JOURNAL OF POWER SOURCES
LA English
DT Article
DE Lithium ion batteries; Silicon; Nanoindentation; Mechanical properties;
AFM; Solid electrolyte interface
ID SOLID-ELECTROLYTE INTERPHASE; ANODE MATERIALS; ELASTIC-MODULUS;
INDENTATION; NANOWIRES; DELITHIATION; SPECTROSCOPY; TEM
AB In this study, atomic force microscopy based nanoindentation techniques are used to measure the in situ mechanical properties of thin film, nanometer sized amorphous-silicon nanopillars (pillar diameters of 1000 nm, 500 nm, and 200 nm) at various stages of lithiation. The pillar indentation modulus and hardness are measured ex situ as-fabricated, in situ during lithiation at two different potentials (or stages of lithiation, 50 mV and 10 mV), and in situ after delithiation at 2 V. The measured modulus of the pristine amorphous silicon nanopillars was 74.7 +/- 12.1 GPa. The hardness of the pristine pillars depended on depth and the contact conditions. In general, the mechanical properties of the nanopillars decreased with increased degrees of lithiation and only partially recovered upon delithiation. The inability of the silicon to recover the as fabricated mechanical properties indicates overall degradation of the pillar during only one lithiation delithiation cycle, which could only be directly measured in situ using the employed atomic force microscopy based technique. Published by Elsevier B.V.
C1 [McAllister, Quinn P.; Strawhecker, Kenneth E.] US Army Res Lab, Weap & Mat Res Directorate, Mat & Mfg Sci Div, ATTN RDRL WMM B, Aberdeen Proving Ground, MD 21005 USA.
[Becker, Collin R.; Lundgren, Cynthia A.] US Army Res Lab, Sensors & Electron Devices Directorate, Energy & Power Div, ATTN RDRL SED C, Adelphi, MD 20783 USA.
RP Becker, CR (reprint author), US Army Res Lab, Electrochem Branch, 2800 Powder Mill Rd, Adelphi, MD 20783 USA.
EM collin.r.becker.civ@mail.mil
FU Army Research Laboratory
FX The authors are grateful to the Army Research Laboratory for financial
support.; The research performed by QPM was supported in part by an
appointment to the Postgraduate Research Participant Program at the U.S.
Army Research Laboratory administered by the Oak Ridge Institute for
Science and Education through an interagency agreement between the U.S.
Department of Energy and USARL.
NR 39
TC 14
Z9 16
U1 4
U2 144
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-7753
EI 1873-2755
J9 J POWER SOURCES
JI J. Power Sources
PD JUL 1
PY 2014
VL 257
BP 380
EP 387
DI 10.1016/j.jpowsour.2014.01.077
PG 8
WC Chemistry, Physical; Electrochemistry; Energy & Fuels; Materials
Science, Multidisciplinary
SC Chemistry; Electrochemistry; Energy & Fuels; Materials Science
GA AE2CD
UT WOS:000333780000049
ER
PT J
AU Sun, XX
Qu, Q
Nasrabadi, NM
Tran, TD
AF Sun, Xiaoxia
Qu, Qing
Nasrabadi, Nasser M.
Tran, Trac D.
TI Structured Priors for Sparse-Representation-Based Hyperspectral Image
Classification
SO IEEE GEOSCIENCE AND REMOTE SENSING LETTERS
LA English
DT Article
DE Classification; hyperspectral image (HSI); sparse representation;
structured priors
ID RECOGNITION
AB Pixelwise classification, where each pixel is assigned to a predefined class, is one of the most important procedures in hyperspectral image (HSI) analysis. By representing a test pixel as a linear combination of a small subset of labeled pixels, a sparse representation classifier (SRC) gives rather plausible results compared with that of traditional classifiers such as the support vector machine. Recently, by incorporating additional structured sparsity priors, the second-generation SRCs have appeared in the literature and are reported to further improve the performance of HSI. These priors are based on exploiting the spatial dependences between the neighboring pixels, the inherent structure of the dictionary, or both. In this letter, we review and compare several structured priors for sparse-representation-based HSI classification. We also propose a new structured prior called the low-rank (LR) group prior, which can be considered as a modification of the LR prior. Furthermore, we will investigate how different structured priors improve the result for the HSI classification.
C1 [Sun, Xiaoxia; Qu, Qing; Tran, Trac D.] Johns Hopkins Univ, Dept Elect & Comp Engn, Baltimore, MD 21218 USA.
[Nasrabadi, Nasser M.] US Army Res Lab, Adelphi, MD 20783 USA.
RP Sun, XX (reprint author), Johns Hopkins Univ, Dept Elect & Comp Engn, Baltimore, MD 21218 USA.
EM xsun9@jhu.edu; qqu2@jhu.edu; nnasraba@arl.army.mil; trac@jhu.edu
FU National Science Foundation [CCF-1117545]; Army Research Office
[60219-MA]; Office of Naval Research [N000141210765]
FX This work was supported in part by the National Science Foundation under
Grant CCF-1117545, by the Army Research Office under Grant 60219-MA, and
by the Office of Naval Research under Grant N000141210765.
NR 21
TC 31
Z9 33
U1 4
U2 29
PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
PI PISCATAWAY
PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA
SN 1545-598X
EI 1558-0571
J9 IEEE GEOSCI REMOTE S
JI IEEE Geosci. Remote Sens. Lett.
PD JUL
PY 2014
VL 11
IS 7
BP 1235
EP 1239
DI 10.1109/LGRS.2013.2290531
PG 5
WC Geochemistry & Geophysics; Engineering, Electrical & Electronic; Remote
Sensing; Imaging Science & Photographic Technology
SC Geochemistry & Geophysics; Engineering; Remote Sensing; Imaging Science
& Photographic Technology
GA AD2VN
UT WOS:000333094000013
ER
PT J
AU Qu, Q
Nasrabadi, NM
Tran, TD
AF Qu, Qing
Nasrabadi, Nasser M.
Tran, Trac D.
TI Abundance Estimation for Bilinear Mixture Models via Joint Sparse and
Low-Rank Representation
SO IEEE TRANSACTIONS ON GEOSCIENCE AND REMOTE SENSING
LA English
DT Article
DE Abundance estimation; bilinear model; hyperspectral imagery; low-rank
representation (LRR); spectral unmixing (SU)
ID NONNEGATIVE MATRIX FACTORIZATION; HYPERSPECTRAL DATA; ENDMEMBER
EXTRACTION; ALGORITHM; IMAGERY
AB Sparsity-based unmixing algorithms, exploiting the sparseness property of the abundances, have recently been proposed with promising performances. However, these algorithms are developed for the linear mixture model (LMM), which cannot effectively handle the nonlinear effects. In this paper, we extend the current sparse regression methods for the LMM to bilinear mixture models (BMMs), where the BMMs introduce additional bilinear terms in the LMM in order to model second-order photon scattering effects. To solve the abundance estimation problem for the BMMs, we propose to perform a sparsity-based abundance estimation by using two dictionaries: a linear dictionary containing all the pure endmembers and a bilinear dictionary consisting of all the possible second-order endmember interaction components. Then, the abundance values can be estimated from the sparse codes associated with the linear dictionary. Moreover, to exploit the spatial data structure where the adjacent pixels are usually homogeneous and are often mixtures of the same materials, we first employ the joint-sparsity (row-sparsity) model to enforce structured sparsity on the abundance coefficients. However, the joint-sparsity model is often a strict assumption, which might cause some aliasing artifacts for the pixels that lie on the boundaries of different materials. To deal with this problem, the low-rank-representation model, which seeks the lowest rank representation of the data, is further introduced to better capture the spatial data structure. Our simulation results demonstrate that the proposed algorithms provide much enhanced performance compared with state-of-the-art algorithms.
C1 [Qu, Qing; Tran, Trac D.] Johns Hopkins Univ, Dept Elect & Comp Engn, Baltimore, MD 21218 USA.
[Nasrabadi, Nasser M.] US Army, Res Lab, Adelphi, MD 20783 USA.
RP Qu, Q (reprint author), Johns Hopkins Univ, Dept Elect & Comp Engn, Baltimore, MD 21218 USA.
EM qqu2@jhu.edu; nnasraba@arl.army.mil; trac@jhu.edu
FU National Science Foundation [CCF-1117545]; Army Research Office
[60219-MA]; Office of Naval Research [N00014-12-1-0765]
FX This work was supported in part by the National Science Foundation under
Grant CCF-1117545, by the Army Research Office under Grant 60219-MA, and
by Office of Naval Research under Grant N00014-12-1-0765.
NR 59
TC 19
Z9 20
U1 2
U2 19
PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
PI PISCATAWAY
PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA
SN 0196-2892
EI 1558-0644
J9 IEEE T GEOSCI REMOTE
JI IEEE Trans. Geosci. Remote Sensing
PD JUL
PY 2014
VL 52
IS 7
BP 4404
EP 4423
DI 10.1109/TGRS.2013.2281981
PG 20
WC Geochemistry & Geophysics; Engineering, Electrical & Electronic; Remote
Sensing; Imaging Science & Photographic Technology
SC Geochemistry & Geophysics; Engineering; Remote Sensing; Imaging Science
& Photographic Technology
GA AC5YO
UT WOS:000332597100056
ER
PT J
AU Convertino, VA
AF Convertino, Victor A.
TI Neurohumoral mechanisms associated with orthostasis: reaffirmation of
the significant contribution of the heart rate response
SO FRONTIERS IN PHYSIOLOGY
LA English
DT Review
DE orthostatic tolerance; blood pressure regulation; lower body negative
pressure; parasympathetic activity; sympathetic activity; propranolol;
atropine
ID BODY NEGATIVE-PRESSURE; CARDIAC NORADRENALINE SPILLOVER; AUTONOMIC
FUNCTIONS; VAGAL BAROREFLEX; TOLERANCE; HUMANS; INTOLERANCE; STRESS;
SPACEFLIGHT; HYPOTENSION
AB The inability to compensate for acute central hypovolemia underlies the clinical development of orthostatic hypotension and instability (e.g., syncope). Although neuro-humoral control of both cardiac output and peripheral vascular resistance contributes to hemodynamic stability during orthostasis, a notion has been proposed that the failure of adequate peripheral vascular constriction rather than cardiac responses represents the primary mechanism underlying the development of orthostatic intolerance. This review article provides an opportunity to present compelling evidence captured over the past 30 years in our laboratory to support the concept that neural-mediated tachycardia during orthostasis in healthy individuals represents a critical response to tolerating acute reduction in central blood volume in addition to, and independent of, peripheral vascular constriction. In this review paper, data are presented from experiments using graded lower body negative pressure (LBNP) as a method to induce orthostatic intolerance in two experimental human models: (1) comparison of heart rate and autonomic responses in individuals with relatively high and low tolerance to LBNP; and (2) vagal and sympathetic blockade of cardiac neural control. These experiments revealed that: (1) greater elevations in heart rate are associated with higher orthostatic (LBNP) tolerance; (2) higher orthostatic heart rate is associated with greater sympathetic nerve activity and withdrawal of vagally-mediated cardiac baroreflex response; and (3) non-specific sympathetic blockade causes a pronounced reduction in heart rate and LBNP tolerance. Cardiac parasympathetic withdrawal contributes to protection against development of hypotension during the initial seconds of transition to an orthostatic challenge, while the primary mechanism by which tachycardia defends orthostatic stability in healthy subjects for extended durations is mediated predominantly through sympathetic adrenergic control.
C1 [Convertino, Victor A.] US Army, Inst Surg Res, Div Res, JBSA Ft Sam Houston, TX 78234 USA.
RP Convertino, VA (reprint author), US Army, Inst Surg Res, 3698 Chambers Pass, JBSA Ft Sam Houston, TX 78234 USA.
EM victor.a.convertino.civ@mail.mil
NR 38
TC 9
Z9 9
U1 0
U2 7
PU FRONTIERS RESEARCH FOUNDATION
PI LAUSANNE
PA PO BOX 110, LAUSANNE, 1015, SWITZERLAND
SN 1664-042X
J9 FRONT PHYSIOL
JI Front. Physiol.
PD JUN 30
PY 2014
VL 5
AR 236
DI 10.3389/fphys.2014.00236
PG 8
WC Physiology
SC Physiology
GA AX6YZ
UT WOS:000347065200001
PM 25071585
ER
PT J
AU Hinojosa-Laborde, C
Ryan, KL
Rickards, CA
Convertino, VA
AF Hinojosa-Laborde, Carmen
Ryan, Kathy L.
Rickards, Caroline A.
Convertino, Victor A.
TI Resting sympathetic baroreflex sensitivity in subjects with low and high
tolerance to central hypovolemia induced by lower body negative pressure
SO FRONTIERS IN PHYSIOLOGY
LA English
DT Article
DE hemorrhage; orthostatic intolerance; autonomic reflex
ID CAROTID-CARDIAC BAROREFLEX; ORTHOSTATIC HYPOTENSION; NERVE ACTIVITY;
VASOCONSTRICTOR RESPONSES; VAGAL BAROREFLEX; HUMANS; HEALTHY;
INTOLERANCE; MODULATION; EXERCISE
AB Central hypovolemia elicited by orthostasis or hemorrhage triggers sympathetically-mediated baroreflex responses to maintain organ perfusion; these reflexes are less sensitive in patients with orthostatic intolerance, and during conditions of severe blood loss, may result in cardiovascular collapse (decompensatory or circulatory shock). The ability to tolerate central hypovolemia is variable and physiological factors contributing to tolerance are emerging. We tested the hypothesis that resting muscle sympathetic nerve activity (MSNA) and sympathetic baroreflex sensitivity (BRS) are attenuated in male and female subjects who have low tolerance (LT) to central hypovolemia induced by lower body negative pressure (LBNP). MSNA and diastolic arterial pressure (DAP) were recorded in 47 human subjects who subsequently underwent LBNP to tolerance (onset of presyncopal symptoms). LT subjects experienced presyncopal symptoms prior to completing LBNP of 60 mm Hg, and subjects with high tolerance (HT) experienced presyncopal symptoms after completing LBNP of 60 mm Hg. Contrary to our hypothesis, resting MSNA burst incidence was not different between LT and HT subjects, and was not related to time to presyncope. BRS was assessed as the slope of the relationship between spontaneous fluctuations in DAP and MSNA during 5 min of supine rest. MSNA burst incidence/DAP correlations were greater than or equal to 0.5 in 37 subjects (LT n = 9; Hi n = 28), and BRS was not different between LT and HT (-1.8+/-0.3 vs. 2.2+/-0.2 bursts.(100 beats)(-1).mm Hg-1, p = 0.29). We conclude that tolerance to central hypovolemia is not related to either resting MSNA or sympathetic BRS.
C1 [Hinojosa-Laborde, Carmen; Ryan, Kathy L.; Convertino, Victor A.] US Army, Inst Surg Res, Ft Sam Houston, TX 78234 USA.
[Rickards, Caroline A.] Univ N Texas, Ctr Hlth Sci, Ft Worth, TX USA.
RP Hinojosa-Laborde, C (reprint author), US Army, Inst Surg Res, 3698 Chambers Pass, JBSA Ft Sam Houston, TX 78234 USA.
EM carmen.hinojosa-laborde.civ@mail.mil
FU United States Army Medical Research and Materiel Command
FX We thank the research volunteers for their cheerful participation, and
Mr. Gary Muniz for his excellent laboratory assistance. This study was
funded by the United States Army Medical Research and Materiel Command.
NR 36
TC 2
Z9 2
U1 0
U2 3
PU FRONTIERS RESEARCH FOUNDATION
PI LAUSANNE
PA PO BOX 110, LAUSANNE, 1015, SWITZERLAND
SN 1664-042X
J9 FRONT PHYSIOL
JI Front. Physiol.
PD JUN 30
PY 2014
VL 5
AR 241
DI 10.3389/fphys.2014.00241
PG 6
WC Physiology
SC Physiology
GA AX6ZB
UT WOS:000347065400001
PM 25071587
ER
PT J
AU Rokni, MR
Widener, CA
Nardi, AT
Champagne, VK
AF Rokni, M. R.
Widener, C. A.
Nardi, A. T.
Champagne, V. K.
TI Nano crystalline high energy milled 5083 Al powder deposited using cold
spray
SO APPLIED SURFACE SCIENCE
LA English
DT Article
DE Cold spray; Nanocrystalline materials; Electron microscopy;
Nanoindentation
ID ULTRAFINE-GRAINED ALUMINUM; MECHANICAL-PROPERTIES; MG ALLOY;
NANOCRYSTALLINE MATERIALS; DEFORMATION; COATINGS; MICROSTRUCTURE;
STRENGTH; COPPER; EVOLUTION
AB Electron microscopy and nanoindentation are used to investigate the relationship between microstructure and nanohardness of a non-cryomilled, nanocrystalline 5083 Al alloy powder before and after being deposited by cold spray. Microstructural investigations observed the presence of nano grains in the powder microstructure, ranging from 20 to 80 nm and with a typical grain size of 40-50 nm. It was also revealed that the nanocrystalline structure of the powder is retained after cold spraying. As a result, almost no change in nanohardness was indicated between the powder and the particles interior in the cold sprayed layer. However, hardness was substantially higher in some regions in the cold sprayed layer, which was attributed to the particle-particle interfaces or other areas with very small nano grain size. The presence of some un-joined particle remnant lines was also found in the deposition and explained through Critical Velocity Ratio (CVR) of powder particles. Although cold spray is a high deformation process, there is little evidence of dislocations within the nanograins of the cold sprayed layer. The latter observation is rationalized through intragranular dislocation slip and recovery mechanisms. (C) 2014 Elsevier B.V. All rights reserved.
C1 [Rokni, M. R.; Widener, C. A.] SDSM&T, Adv Mat Proc Ctr, Dept Mat & Met Engn, Rapid City, SD USA.
[Nardi, A. T.] United Technol Res Ctr, East Hartford, CT USA.
[Champagne, V. K.] US Army Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD USA.
RP Rokni, MR (reprint author), SDSM&T, Adv Mat Proc Ctr, Dept Mat & Met Engn, Rapid City, SD USA.
EM mohammadreza.rokni@mines.sdsmt.edu
NR 49
TC 6
Z9 6
U1 2
U2 26
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0169-4332
EI 1873-5584
J9 APPL SURF SCI
JI Appl. Surf. Sci.
PD JUN 30
PY 2014
VL 305
BP 797
EP 804
DI 10.1016/j.apsusc.2014.03.010
PG 8
WC Chemistry, Physical; Materials Science, Coatings & Films; Physics,
Applied; Physics, Condensed Matter
SC Chemistry; Materials Science; Physics
GA AI0GY
UT WOS:000336525400111
ER
PT J
AU Polashenski, C
Courville, Z
Benson, C
Wagner, A
Chen, J
Wong, G
Hawley, R
Hall, D
AF Polashenski, Chris
Courville, Zoe
Benson, Carl
Wagner, Anna
Chen, Justin
Wong, Gifford
Hawley, Robert
Hall, Dorothy
TI Observations of pronounced Greenland ice sheet firn warming and
implications for runoff production
SO GEOPHYSICAL RESEARCH LETTERS
LA English
DT Article
ID SEA-LEVEL RISE; MELT EXTENT; MODIS; ACCUMULATION; VARIABILITY
AB Field measurements of shallow borehole temperatures in firn across the northern Greenland ice sheet are collected during May 2013. Sites first measured in 1952-1955 are revisited, showing long-term trends in firn temperature. Results indicate a pattern of substantial firn warming (up to +5.7 degrees C) at midlevel elevations (1400-2500 m) and little temperature change at high elevations (>2500 m). We find that latent heat transport into the firn due to meltwater percolation drives the observed warming. Modeling shows that heat is stored at depth for several years, and energy delivered from consecutive melt events accumulates in the firn. The observed warming is likely not yet in equilibrium with recent melt production rates but captures the progression of sites in the percolation facies toward net runoff production.
C1 [Polashenski, Chris; Wagner, Anna] US Army Cold Reg Res & Engn Lab, Ft Wainwright, AK 99703 USA.
[Polashenski, Chris; Courville, Zoe] Dartmouth Coll, Thayer Sch Engn, Hanover, NH 03755 USA.
[Courville, Zoe] US Army Cold Reg Res & Engn Lab, Hanover, NH USA.
[Benson, Carl] Univ Alaska Fairbanks, Inst Geophys, Fairbanks, AK 99775 USA.
[Chen, Justin] Hanover High Sch, Hanover, NH USA.
[Wong, Gifford; Hawley, Robert] Dartmouth Coll, Dept Earth Sci, Hanover, NH 03755 USA.
[Hall, Dorothy] NASA, Goddard Space Flight Ctr, Greenbelt, MD 20771 USA.
RP Polashenski, C (reprint author), US Army Cold Reg Res & Engn Lab, Ft Wainwright, AK 99703 USA.
EM chris.polashenski@gmail.com
FU National Science Foundation Division of Polar Programs, the NSF award
[1204145]
FX We would like to acknowledge the support provided by the National
Science Foundation Division of Polar Programs, the NSF award 1204145,
the able and cheerful assistance of Michael Stewart, Nathan Stewart, and
Thomas Overly in the collection of temperature data, and the logistics
provided by CH2MHill Polar Field Services and Stanford Research
Institute teams. We thank Koni Steffen for sharing up to date GC-Net
Data used to extend relevant analyses. All data used in this publication
can be accessed in the National Snow and Ice Data Center Advanced
Cooperative Arctic Data and Information Service website:
nsidc.org/acadis. The authors thank two anonymous reviewers for their
helpful comments in improving this paper.
NR 48
TC 6
Z9 6
U1 4
U2 19
PU AMER GEOPHYSICAL UNION
PI WASHINGTON
PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA
SN 0094-8276
EI 1944-8007
J9 GEOPHYS RES LETT
JI Geophys. Res. Lett.
PD JUN 28
PY 2014
VL 41
IS 12
BP 4238
EP 4246
DI 10.1002/2014GL059806
PG 9
WC Geosciences, Multidisciplinary
SC Geology
GA AN0SM
UT WOS:000340294300018
ER
PT J
AU Jae, LT
Raaben, M
Herbert, AS
Kuehne, AI
Wirchnianski, AS
Soh, TK
Stubbs, SH
Janssen, H
Damme, M
Saftig, P
Whelan, SP
Dye, JM
Brummelkamp, TR
AF Jae, Lucas T.
Raaben, Matthijs
Herbert, Andrew S.
Kuehne, Ana I.
Wirchnianski, Ariel S.
Soh, Timothy K.
Stubbs, Sarah H.
Janssen, Hans
Damme, Markus
Saftig, Paul
Whelan, Sean P.
Dye, John M.
Brummelkamp, Thijn R.
TI Lassa virus entry requires a trigger-induced receptor switch
SO SCIENCE
LA English
DT Article
ID LYMPHOCYTIC CHORIOMENINGITIS VIRUS; ALPHA-DYSTROGLYCAN; HUMAN AIRWAY;
MEMBRANE; BINDING; SPECIFICITY; INHIBITORS; COMPLEX; FEVER; CELLS
AB Lassa virus spreads from a rodent to humans and can lead to lethal hemorrhagic fever. Despite its broad tropism, chicken cells were reported 30 years ago to resist infection. We found that Lassa virus readily engaged its cell-surface receptor a-dystroglycan in avian cells, but virus entry in susceptible species involved a pH-dependent switch to an intracellular receptor, the lysosome-resident protein LAMP1. Iterative haploid screens revealed that the sialyltransferase ST3GAL4 was required for the interaction of the virus glycoprotein with LAMP1. A single glycosylated residue in LAMP1, present in susceptible species but absent in birds, was essential for interaction with the Lassa virus envelope protein and subsequent infection. The resistance of Lamp1-deficient mice to Lassa virus highlights the relevance of this receptor switch in vivo.
C1 [Jae, Lucas T.; Raaben, Matthijs; Janssen, Hans; Brummelkamp, Thijn R.] Netherlands Canc Inst, NL-1066 CX Amsterdam, Netherlands.
[Raaben, Matthijs; Soh, Timothy K.; Stubbs, Sarah H.; Whelan, Sean P.] Harvard Univ, Sch Med, Dept Microbiol & Immunobiol, Boston, MA 02115 USA.
[Herbert, Andrew S.; Kuehne, Ana I.; Wirchnianski, Ariel S.; Dye, John M.] US Army, Med Res Inst Infect Dis, Frederick, MD 21702 USA.
[Damme, Markus; Saftig, Paul] Univ Kiel, Inst Biochem, D-24118 Kiel, Germany.
[Brummelkamp, Thijn R.] Austrian Acad Sci, CeMM Res Ctr Mol Med, A-1090 Vienna, Austria.
[Brummelkamp, Thijn R.] Cancer Genom Ctr CGC Nl, NL-1066 CX Amsterdam, Netherlands.
RP Brummelkamp, TR (reprint author), Netherlands Canc Inst, Plesmanlaan 121, NL-1066 CX Amsterdam, Netherlands.
EM sean_whelan@hms.harvard.edu; john.m.dye1.civ@mail.mil;
t.brummelkamp@nki.nl
RI Saftig, Paul/A-7966-2010
FU CGC.nl; Nederlandse Organisatie voor Wetenschappelijk Onderzoek Vidi
grant [91711316]; European Research Council (ERC) Starting Grant
[ERC-2012-StG 309634]; Deutsche Forschungsgemeinschaft [DFG SPP1580,
GRK1459]; NIH [AI081842, AI109740]; Defense Threat Reduction Agency
[CB3947]
FX We thank T. Sixma, A. Perrakis, E. von Castelmur, D. Lefeber, and
members of the Brummelkamp group for discussion; M. Rusch for mouse
breeding; S. Kunz for a plasmid encoding Lassa-GP; E. Ollmann-Saphire
for an Fc-fusion vector; R. Schoepp for GP1 antibodies; and M. Verheije
for DF1 cells. This work was supported by CGC.nl, Nederlandse
Organisatie voor Wetenschappelijk Onderzoek Vidi grant 91711316, and
European Research Council (ERC) Starting Grant (ERC-2012-StG 309634) to
T. R. B.; Deutsche Forschungsgemeinschaft (DFG SPP1580 and GRK1459) to
P. S.; and NIH grants AI081842 and AI109740 to S. P. W. J.M.D was
supported by the Defense Threat Reduction Agency (CB3947). The HAP1
cells that were used are distributed under a materials transfer
agreement. Opinions, interpretations, conclusions, and recommendations
are those of the author and are not necessarily endorsed by the U.S.
Army. T. R. B. is a cofounder and shareholder of Haplogen GmbH, a
company involved in haploid genetics. Sequencing data are accessible at
www.ncbi.nlm.nih.gov/sra (accession SRP041566).
NR 23
TC 41
Z9 43
U1 7
U2 35
PU AMER ASSOC ADVANCEMENT SCIENCE
PI WASHINGTON
PA 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 USA
SN 0036-8075
EI 1095-9203
J9 SCIENCE
JI Science
PD JUN 27
PY 2014
VL 344
IS 6191
BP 1506
EP 1510
DI 10.1126/science.1252480
PG 5
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA AJ7PZ
UT WOS:000337889900048
PM 24970085
ER
PT J
AU McCormack, R
Apostle, K
Boyer, D
Moola, F
Perey, B
Stone, T
Viskontas, D
Lemke, HM
Zomar, M
Moon, K
Moon, R
Oatt, A
Buckley, RE
Duffy, P
Korley, R
Puloski, S
Johnston, K
Powell, J
Carcary, K
Sanders, D
Lawendy, A
Tieszer, C
Stephen, D
Kreder, H
Jenkinson, R
Nousiainen, M
Axelrod, T
Murnaghan, J
Nam, D
Wadey, V
Yee, A
Milner, K
Kunz, M
Schemitsch, EH
Ahn, H
Hall, JA
McKee, MD
Whelan, DB
Nauth, A
Vicente, MR
Wild, LM
Khan, RM
Hidy, JT
Coles, C
Leighton, R
Biddulph, M
Johnston, D
Glazebrook, M
Alexander, D
Coady, C
Dunbar, M
Amirault, D
Gross, M
Oxner, W
Reardon, G
Richardson, G
Trenholm, A
Wong, I
Trask, K
MacDonald, S
Dobbin, G
Bicknell, R
Yach, J
Bardana, D
Wood, G
Harrison, M
Yen, D
Lambert, S
Howells, F
Ward, A
Zalzal, P
Brien, H
Naumetz, V
Weening, B
Simunovic, N
Wai, EK
Papp, S
Gofton, WT
Liew, A
Kingwell, SP
Johnson, G
O'Neil, J
Roffey, DM
Borsella, V
Avram, V
Oliver, TM
Jones, V
Jones, CB
Ringler, JR
Endres, TJ
Sietsema, DL
Jeray, KJ
Broderick, JS
Goetz, DR
Pace, TB
Schaller, TM
Porter, SE
Tanner, SL
Snider, RG
Nastoff, LA
Bielby, SA
Switzer, JA
Cole, PA
Anderson, SA
Lafferty, PM
Li, MN
Ly, TV
Marston, SB
Foley, AL
Vang, S
Wright, DM
Marcantonio, AJ
Kain, MSH
Iorio, R
Specht, LM
Tilzey, JF
Lobo, MJ
Garfi, JS
Vallier, HA
Dolenc, A
Robinson, C
Prayson, MJ
Laughlin, R
Rubino, LJ
May, J
Rieser, GR
Dulaney-Cripe, L
Gayton, C
Shaer, J
Schrickel, T
Hileman, B
Gorczyca, JT
Gross, JM
Humphrey, CA
Kates, S
Noble, K
McIntyre, AW
Pecorella, K
Davis, CA
Weinerman, S
Weingarten, P
Stull, P
Lindenbaum, S
Hewitt, M
Schwappach, J
Baker, JK
Rutherford, T
Newman, H
Lieberman, S
Finn, E
Robbins, K
Hurley, M
Lyle, L
Mitchell, K
Browner, K
Whatley, E
Payton, K
Reeves, C
Cannada, LK
Karges, D
Hill, L
Mehta, S
Esterhai, J
Ahn, J
Horan, AD
McGinnis, K
Kaminski, CA
Kowalski, BN
Keeve, JP
Anderson, CG
McDonald, MD
Hoffman, JM
Tarkin, I
Siska, P
Gruen, G
Evans, A
Farrell, DJ
Irrgang, J
Luther, A
Cross, WW
Cass, JR
Sems, SA
Torchia, ME
Scrabeck, T
Jenkins, M
Dumais, J
Romero, AW
Sagebien, CA
Butler, MS
Monica, JT
Seuffert, P
Hsu, JR
Ficke, J
Charlton, M
Napierala, M
Fan, M
Tornetta, P
Tannoury, C
Carlisle, H
Silva, H
Archdeacon, M
Finnan, R
Le, T
Wyrick, J
Hess, S
Brennan, ML
Probe, R
Kile, E
Mills, K
Clipper, L
Yu, M
Erwin, K
Horwitz, D
Strohecker, K
Swenson, TK
Aurang, K
Zohman, G
Peterson, B
Huff, RB
Baele, J
Weber, T
Edison, M
McBeth, J
Shively, K
Ertl, JP
Mullis, B
Parr, JA
Worman, R
Frizzell, V
Moore, MM
Tobias, E
Thomas, E
DePaolo, CJ
Alosky, R
Shell, LE
Hampton, L
Shepard, S
Nanney, T
Cuento, C
Cantu, RV
Henderson, ER
Eickhoff, LS
Hammerberg, EM
Stahel, P
Hak, D
Mauffrey, C
Gibula, D
Gissel, H
Henderson, C
Zamorano, DP
Tynan, MC
Pourmand, D
Lawson, D
Della Rocca, GJ
Crist, BD
Murtha, YM
Anderson, LK
Linehan, C
Pilling, L
Lewis, CG
Caminiti, S
Sullivan, RJ
Roper, E
Obremskey, W
Kregor, P
Richards, JE
Stringfellow, K
Dohm, MP
Zellar, A
Segers, MJM
Zijl, JAC
Verhoeven, B
Smits, AB
de Vries, JPPM
Fioole, B
van der Hoeven, H
Theunissen, EBM
Reilingh, TSD
Govaert, L
Wittich, P
de Brauw, M
Wille, J
Go, PMNYM
Ritchie, ED
Wessel, RN
Hammacher, ER
Heetveld, MJ
Visser, GA
Stockmann, H
Silvis, R
Snellen, JP
Rijbroek, B
Scheepers, JJG
Vermeulen, EGJ
Siroen, MPC
Vuylsteke, R
Brom, HLF
Rijna, H
de Rijcke, PAR
Koppert, CL
Buijk, SE
Groenendijk, RPR
Dawson, I
Tetteroo, GWM
Bruijninckx, MMM
Doornebosch, PG
de Graaf, EJR
van der Elst, M
van der Pol, CC
van 't Riet, M
Karsten, TM
de Vries, MR
Stassen, LPS
Schep, NWL
Ben Schmidt, G
Hoffman, WH
Poolman, RW
Simons, MP
van der Heijden, FHWM
Willems, WJ
de Meulemeester, FRAJ
van der Hart, CP
Turckan, K
Festen, S
de Nies, F
Haverlag, R
Out, NJM
Bosma, J
van Kampen, A
Biert, J
van Vugt, AB
Edwards, MJR
Blokhuis, TJ
Frolke, JPM
Geeraedts, LMG
Gardeniers, JWM
Tan, ETCH
Poelhekke, LMSJ
Malefijt, MCD
Schreurs, B
Roukema, GR
Josaputra, HA
Keller, P
de Rooij, PD
Kuiken, H
Boxma, H
Cleffken, BI
Liem, R
Rhemrev, SJ
Bosman, CHR
van Otterloo, AD
Hoogendoorn, J
de Vries, AC
Meylaerts, SAG
Verhofstad, MHJ
Meijer, J
van Egmond, T
van der Heijden, FHWM
van der Brand, I
Patka, P
Eversdijk, MG
Peters, R
Den Hartog, D
Van Waes, OJF
Oprel, P
van der Vis, HM
Campo, M
Verhagen, R
Albers, GHR
Zurcher, AW
Simmermacher, RKJ
van Mulken, J
van Wessem, K
Blokhuis, TJ
van Gaalen, SM
Leenen, LPH
Bronkhorst, MWGA
Guicherit, OR
Goslings, JC
Haverlag, R
Ponsen, KJ
Bhatia, M
Arora, V
Tyagi, V
Liew, S
Bedi, H
Carr, A
Curry, H
Chia, A
Csongvay, S
Donohue, C
Doig, S
Edwards, E
Etherington, G
Esser, M
Gong, A
Jain, A
Li, D
Miller, R
Moaveni, A
Russ, M
Ton, L
Wang, O
Dowrick, A
Murdoch, Z
Sage, C
Frihagen, F
Clarke-Jenssen, J
Hjorthaug, G
Ianssen, T
Amundsen, A
Brattgjerd, JE
Borch, T
Boe, B
Flatoy, B
Hasselund, S
Haug, KJ
Hemlock, K
Hoseth, TM
Jomaas, G
Kibsgard, T
Lona, T
Moatshe, G
Muller, O
Molund, M
Nicolaisen, T
Nilsen, F
Rydinge, J
Smedsrud, M
Stodle, A
Trommer, A
Ugland, S
Karlsten, A
Ekas, G
Vesterhus, EB
Brekke, AC
Gupta, A
Jain, N
Khan, F
Sharma, A
Sanghavi, A
Trivedi, M
Rai, A
Subash
Rai, K
Yadav, V
Singh, S
Rai, K
Tetsworth, K
Donald, G
Weinrauch, P
Pincus, P
Yang, S
Halliday, B
Gervais, T
Holt, M
Flynn, A
Prasad, AS
Mishra, V
Sundaresh, DC
Khanna, A
Cherian, JJ
Olakkengil, DJ
Sharma, G
Pirpiris, M
Love, D
Bucknill, A
Farrugia, RJ
Pape, HC
Knobe, M
Pfeifer, R
Hull, P
Lewis, S
Evans, S
Nanda, R
Logishetty, R
Anand, S
Bowler, C
Dadi, A
Palla, N
Ganguly, U
Rai, BS
Rajakumar, J
Jennings, A
Chuter, G
Rose, G
Horner, G
Clark, C
Eke, K
Reed, M
Herriott, C
Dobb, C
Bhandari, M
Swiontkowski, M
Devereaux, P
Schemitsch, EH
Heetveld, MJ
Jeray, K
Liew, S
Thabane, L
Walter, S
Sprague, S
Scott, T
Guyatt, G
Bhandari, M
Swiontkowski, M
Devereaux, P
Guyatt, G
Heetveld, MJ
Jeray, K
Liew, S
Schemitsch, EH
Thabane, L
Walter, S
Bhandari, M
Sprague, S
Viveiros, H
McKay, P
Scott, T
Swinton, M
Truong, V
Koo, K
Heels-Ansdell, D
Zhou, Q
Buckingham, L
Duraikannan, A
Maddock, D
Simunovic, N
Swiontkowski, M
Agel, J
Heetveld, MJ
Van Lieshout, EMM
Zielinski, SM
Rangan, A
Hanusch, BC
Kottam, L
Clarkson, R
Della Rocca, GJ
Haverlag, R
Liew, S
Slobogean, G
Katz, J
Gillespie, B
Greendale, GA
Guy, P
Hartman, C
Rubin, C
Waddell, J
AF McCormack, Robert
Apostle, Kelly
Boyer, Dory
Moola, Farhad
Perey, Bertrand
Stone, Trevor
Viskontas, Darius
Lemke, H. Michael
Zomar, Mauri
Moon, Karyn
Moon, Raely
Oatt, Amber
Buckley, Richard E.
Duffy, Paul
Korley, Robert
Puloski, Shannon
Johnston, Kelly
Powell, James
Carcary, Kimberly
Sanders, David
Lawendy, Abdel
Tieszer, Christina
Stephen, David
Kreder, Hans
Jenkinson, Richard
Nousiainen, Markku
Axelrod, Terry
Murnaghan, John
Nam, Diane
Wadey, Veronica
Yee, Albert
Milner, Katrine
Kunz, Monica
Schemitsch, Emil H.
Ahn, Henry
Hall, Jeremy A.
McKee, Michael D.
Whelan, Daniel B.
Nauth, Aaron
Vicente, Milena R.
Wild, Lisa M.
Khan, Ryan M.
Hidy, Jennifer T.
Coles, Chad
Leighton, Ross
Biddulph, Michael
Johnston, David
Glazebrook, Mark
Alexander, David
Coady, Cathy
Dunbar, Michael
Amirault, David
Gross, Michael
Oxner, William
Reardon, Gerald
Richardson, Glen
Trenholm, Andrew
Wong, Ivan
Trask, Kelly
MacDonald, Shelley
Dobbin, Gwen
Bicknell, Ryan
Yach, Jeff
Bardana, Davide
Wood, Gavin
Harrison, Mark
Yen, David
Lambert, Sue
Howells, Fiona
Ward, Angela
Zalzal, Paul
Brien, Heather
Naumetz, V.
Weening, Brad
Simunovic, Nicole
Wai, Eugene K.
Papp, Steve
Gofton, Wade T.
Liew, Allen
Kingwell, Stephen P.
Johnson, Garth
O'Neil, Joseph
Roffey, Darren M.
Borsella, Vivian
Avram, Victoria
Oliver, Todd M.
Jones, Vicki
Jones, Clifford B.
Ringler, James R.
Endres, Terrence J.
Sietsema, Debra L.
Jeray, Kyle J.
Broderick, J. Scott
Goetz, David R.
Pace, Thomas B.
Schaller, Thomas M.
Porter, Scott E.
Tanner, Stephanie L.
Snider, Rebecca G.
Nastoff, Lauren A.
Bielby, Shea A.
Switzer, Julie A.
Cole, Peter A.
Anderson, Sarah A.
Lafferty, Paul M.
Li, Mengnai
Ly, Thuan V.
Marston, Scott B.
Foley, Amy L.
Vang, Sandy
Wright, David M.
Marcantonio, Andrew J.
Kain, Michael S. H.
Iorio, Richard
Specht, Lawrence M.
Tilzey, John F.
Lobo, Margaret J.
Garfi, John S.
Vallier, Heather A.
Dolenc, Andrea
Robinson, Chalitha
Prayson, Michael J.
Laughlin, Richard
Rubino, L. Joseph
May, Jedediah
Rieser, Geoffrey Ryan
Dulaney-Cripe, Liz
Gayton, Chris
Shaer, James
Schrickel, Tyson
Hileman, Barbara
Gorczyca, John T.
Gross, Jonathan M.
Humphrey, Catherine A.
Kates, Stephen
Noble, Krista
McIntyre, Allison W.
Pecorella, Kaili
Davis, Craig A.
Weinerman, Stewart
Weingarten, Peter
Stull, Philip
Lindenbaum, Stephen
Hewitt, Michael
Schwappach, John
Baker, Janell K.
Rutherford, Tori
Newman, Heike
Lieberman, Shane
Finn, Erin
Robbins, Kristin
Hurley, Meghan
Lyle, Lindsey
Mitchell, Khalis
Browner, Kieran
Whatley, Erica
Payton, Krystal
Reeves, Christina
Cannada, Lisa K.
Karges, David
Hill, Leslie
Mehta, Samir
Esterhai, John
Ahn, Jaimo
Horan, Annamarie D.
McGinnis, Kelly
Kaminski, Christine A.
Kowalski, Brynn N.
Keeve, Jonathan P.
Anderson, Christopher G.
McDonald, Michael D.
Hoffman, Jodi M.
Tarkin, Ivan
Siska, Peter
Gruen, Gary
Evans, Andrew
Farrell, Dana J.
Irrgang, James
Luther, Arlene
Cross, William W., III
Cass, Joseph R.
Sems, Stephen A.
Torchia, Michael E.
Scrabeck, Tyson
Jenkins, Mark
Dumais, Jules
Romero, Amanda W.
Sagebien, Carlos A.
Butler, Mark S.
Monica, James T.
Seuffert, Patricia
Hsu, Joseph R.
Ficke, James
Charlton, Michael
Napierala, Matthew
Fan, Mary
Tornetta, Paul, III
Tannoury, Chadi
Carlisle, Hope
Silva, Heather
Archdeacon, Michael
Finnan, Ryan
Le, Toan
Wyrick, John
Hess, Shelley
Brennan, Michael L.
Probe, Robert
Kile, Evelyn
Mills, Kelli
Clipper, Lydia
Yu, Michelle
Erwin, Katie
Horwitz, Daniel
Strohecker, Kent
Swenson, Teresa K.
Aurang, Kamran
Zohman, Gary
Peterson, Brett
Huff, Roger B.
Baele, Joseph
Weber, Timothy
Edison, Matt
McBeth, Jessica
Shively, Karl
Ertl, Janos P.
Mullis, Brian
Parr, J. Andrew
Worman, Ripley
Frizzell, Valda
Moore, Molly M.
Tobias, Erin
Thomas, Emily
DePaolo, Charles J.
Alosky, Rachel
Shell, Leslie E.
Hampton, Lynne
Shepard, Stephanie
Nanney, Tracy
Cuento, Claudine
Cantu, Robert V.
Henderson, Eric R.
Eickhoff, Linda S.
Hammerberg, E. Mark
Stahel, Philip
Hak, David
Mauffrey, Cyril
Gibula, Douglas
Gissel, Hannah
Henderson, Corey
Zamorano, David P.
Tynan, Martin C.
Pourmand, Deeba
Lawson, Deanna
Della Rocca, Gregory J.
Crist, Brett D.
Murtha, Yvonne M.
Anderson, Linda K.
Linehan, Colleen
Pilling, Lindsey
Lewis, Courtland G.
Caminiti, Stephanie
Sullivan, Raymond J.
Roper, Elizabeth
Obremskey, William
Kregor, Philip
Richards, Justin E.
Stringfellow, Kenya
Dohm, Michael P.
Zellar, Abby
Segers, Michiel J. M.
Zijl, Jacco A. C.
Verhoeven, Bart
Smits, Anke B.
de Vries, Jean Paul P. M.
Fioole, Bram
van der Hoeven, Henk
Theunissen, Evert B. M.
Reilingh, Tammo S. de Vries
Govaert, Lonneke
Wittich, Philippe
de Brauw, Maurits
Wille, Jan
Go, Peter M. N. Y. M.
Ritchie, Ewan D.
Wessel, Ronald N.
Hammacher, Eric R.
Heetveld, Martin J.
Visser, Gijs A.
Stockmann, Heyn
Silvis, Rob
Snellen, Jaap P.
Rijbroek, Bram
Scheepers, Joris J. G.
Vermeulen, Erik G. J.
Siroen, Michiel P. C.
Vuylsteke, Ronald
Brom, Hans L. F.
Rijna, Herman
de Rijcke, Piet A. R.
Koppert, Cees L.
Buijk, Steven E.
Groenendijk, Richard P. R.
Dawson, Imro
Tetteroo, Geert W. M.
Bruijninckx, Milko M. M.
Doornebosch, Pascal G.
de Graaf, Eelco J. R.
van der Elst, Maarten
van der Pol, Carmen C.
van 't Riet, Martijne
Karsten, Tom M.
de Vries, Mark R.
Stassen, Laurents P. S.
Schep, Niels W. L.
Ben Schmidt, G.
Hoffman, W. H.
Poolman, Rudolf W.
Simons, Maarten P.
van der Heijden, Frank H. W. M.
Willems, W. Jaap
de Meulemeester, Frank R. A. J.
van der Hart, Cor P.
Turckan, Kahn
Festen, Sebastiaan
de Nies, Frank
Haverlag, Robert
Out, Nico J. M.
Bosma, Jan
van Kampen, Albert
Biert, Jan
van Vugt, Arie B.
Edwards, Michael J. R.
Blokhuis, Taco J.
Frolke, Jan Paul M.
Geeraedts, Leo M. G.
Gardeniers, Jean W. M.
Tan, Edward T. C. H.
Poelhekke, Lodewijk M. S. J.
Malefijt, Maarten C. de Waal
Schreurs, Bart
Roukema, Gert R.
Josaputra, Hong A.
Keller, Paul
de Rooij, Peter D.
Kuiken, Hans
Boxma, Han
Cleffken, Berry I.
Liem, Ronald
Rhemrev, Steven J.
Bosman, Coks H. R.
van Otterloo, Alexander de Mol
Hoogendoorn, Jochem
de Vries, Alexander C.
Meylaerts, Sven A. G.
Verhofstad, Michiel H. J.
Meijer, Joost
van Egmond, Teun
van der Heijden, Frank H. W. M.
van der Brand, Igor
Patka, Peter
Eversdijk, Martin G.
Peters, Rolf
Den Hartog, Dennis
Van Waes, Oscar J. F.
Oprel, Pim
van der Vis, Harm M.
Campo, Martin
Verhagen, Ronald
Albers, G. H. Robert
Zurcher, Arthur W.
Simmermacher, Rogier K. J.
van Mulken, Jeroen
van Wessem, Karlijn
Blokhuis, Taco J.
van Gaalen, Steven M.
Leenen, Luke P. H.
Bronkhorst, Maarten W. G. A.
Guicherit, Onno R.
Goslings, J. Carel
Haverlag, Robert
Ponsen, Kees Jan
Bhatia, Mahesh
Arora, Vinod
Tyagi, Vivek
Liew, Susan
Bedi, Harvinder
Carr, Ashley
Curry, Hamish
Chia, Andrew
Csongvay, Steve
Donohue, Craig
Doig, Stephen
Edwards, Elton
Etherington, Greg
Esser, Max
Gong, Andrew
Jain, Arvind
Li, Doug
Miller, Russell
Moaveni, Ash
Russ, Matthias
Ton, Lu
Wang, Otis
Dowrick, Adam
Murdoch, Zoe
Sage, Claire
Frihagen, Frede
Clarke-Jenssen, John
Hjorthaug, Geir
Ianssen, Torben
Amundsen, Asgeir
Brattgjerd, Jan Egil
Borch, Tor
Boe, Berthe
Flatoy, Bernhard
Hasselund, Sondre
Haug, Knut Jorgen
Hemlock, Kim
Hoseth, Tor Magne
Jomaas, Geir
Kibsgard, Thomas
Lona, Tarjei
Moatshe, Gilbert
Muller, Oliver
Molund, Marius
Nicolaisen, Tor
Nilsen, Fredrik
Rydinge, Jonas
Smedsrud, Morten
Stodle, Are
Trommer, Axel
Ugland, Stein
Karlsten, Anders
Ekas, Guri
Vesterhus, Elise Berg
Brekke, Anne Christine
Gupta, Ajay
Jain, Neeraj
Khan, Farah
Sharma, Ateet
Sanghavi, Amir
Trivedi, Mittal
Rai, Anil
Subash
Rai, Kamal
Yadav, Vineet
Singh, Sanjay
Rai, Kamal
Tetsworth, Kevin
Donald, Geoff
Weinrauch, Patrick
Pincus, Paul
Yang, Steven
Halliday, Brett
Gervais, Trevor
Holt, Michael
Flynn, Annette
Prasad, Amal Shankar
Mishra, Vimlesh
Sundaresh, D. C.
Khanna, Angshuman
Cherian, Joe Joseph
Olakkengil, Davy J.
Sharma, Gaurav
Pirpiris, Marinis
Love, David
Bucknill, Andrew
Farrugia, Richard J.
Pape, Hans-Christoph
Knobe, Matthias
Pfeifer, Roman
Hull, Peter
Lewis, Sophie
Evans, Simone
Nanda, Rajesh
Logishetty, Rajanikanth
Anand, Sanjeev
Bowler, Carol
Dadi, Akhil
Palla, Naveen
Ganguly, Utsav
Rai, B. Sachidananda
Rajakumar, Janakiraman
Jennings, Andrew
Chuter, Graham
Rose, Glynis
Horner, Gillian
Clark, Callum
Eke, Kate
Reed, Mike
Herriott, Chris
Dobb, Christine
Bhandari, Mohit
Swiontkowski, Marc
Devereaux, Pj
Schemitsch, Emil H.
Heetveld, Martin J.
Jeray, Kyle
Liew, Susan
Thabane, Lehana
Walter, Stephen
Sprague, Sheila
Scott, Taryn
Guyatt, Gordon
Bhandari, Mohit
Swiontkowski, Marc
Devereaux, Pj
Guyatt, Gordon
Heetveld, Martin J.
Jeray, Kyle
Liew, Susan
Schemitsch, Emil H.
Thabane, Lehana
Walter, Stephen
Bhandari, Mohit
Sprague, Sheila
Viveiros, Helena
McKay, Paula
Scott, Taryn
Swinton, Marilyn
Truong, Victoria
Koo, Kaitlin
Heels-Ansdell, Diane
Zhou, Qi
Buckingham, Lisa
Duraikannan, Aravin
Maddock, Deborah
Simunovic, Nicole
Swiontkowski, Marc
Agel, Julie
Heetveld, Martin J.
Van Lieshout, Esther M. M.
Zielinski, Stephanie M.
Rangan, Amar
Hanusch, Birgit C.
Kottam, Lucksy
Clarkson, Rachel
Della Rocca, Gregory J.
Haverlag, Robert
Liew, Susan
Slobogean, Gerard
Katz, Jeffrey
Gillespie, Brenda
Greendale, Gail A.
Guy, Pierre
Hartman, Curtis
Rubin, Craig
Waddell, James
CA FAITH Investigators
TI Fixation using alternative implants for the treatment of hip fractures
(FAITH): design and rationale for a multi-centre randomized trial
comparing sliding hip screws and cancellous screws on revision surgery
rates and quality of life in the treatment of femoral neck fractures
SO BMC MUSCULOSKELETAL DISORDERS
LA English
DT Article
DE Hip fractures; Femoral neck fractures; Fracture fixation; Internal
fixation; Cancellous screws; Sliding hip screw
ID 2-YEAR FOLLOW-UP; INTERNAL-FIXATION; DISPLACED FRACTURES; SHORT-FORM;
UNITED-STATES; DYNAMIC HIP; ARTHROPLASTY; METAANALYSIS; OUTCOMES;
HEMIARTHROPLASTY
AB Background: Hip fractures are a common type of fragility fracture that afflict 293,000 Americans (over 5,000 per week) and 35,000 Canadians (over 670 per week) annually. Despite the large population impact the optimal fixation technique for low energy femoral neck fractures remains controversial. The primary objective of the FAITH study is to assess the impact of cancellous screw fixation versus sliding hip screws on rates of revision surgery at 24 months in individuals with femoral neck fractures. The secondary objective is to determine the impact on health-related quality of life, functional outcomes, health state utilities, fracture healing, mortality and fracture-related adverse events.
Methods/Design: FAITH is a multi-centre, multi-national randomized controlled trial utilizing minimization to determine patient allocation. Surgeons in North America, Europe, Australia, and Asia will recruit a total of at least 1,000 patients with low-energy femoral neck fractures. Using central randomization, patients will be allocated to receive surgical treatment with cancellous screws or a sliding hip screw. Patient outcomes will be assessed at one week (baseline), 10 weeks, 6, 12, 18, and 24 months post initial fixation. We will independently adjudicate revision surgery and complications within 24 months of the initial fixation. Outcome analysis will be performed using a Cox proportional hazards model and likelihood ratio test.
Discussion: This study represents major international efforts to definitively resolve the treatment of low-energy femoral neck fractures. This trial will not only change current Orthopaedic practice, but will also set a benchmark for the conduct of future Orthopaedic trials.
C1 [McCormack, Robert; Apostle, Kelly; Boyer, Dory; Moola, Farhad; Perey, Bertrand; Stone, Trevor; Viskontas, Darius; Lemke, H. Michael; Zomar, Mauri; Moon, Karyn; Moon, Raely; Oatt, Amber] Univ British Columbia, Fraser Hlth Author, Vancouver, BC V5Z 1M9, Canada.
[Buckley, Richard E.; Duffy, Paul; Korley, Robert; Puloski, Shannon; Johnston, Kelly; Powell, James; Carcary, Kimberly] Foothills Med Ctr, Calgary, AB, Canada.
[Sanders, David; Lawendy, Abdel; Tieszer, Christina] London Hlth Sci Ctr, London, ON, Canada.
[Stephen, David; Kreder, Hans; Jenkinson, Richard; Nousiainen, Markku; Axelrod, Terry; Murnaghan, John; Nam, Diane; Wadey, Veronica; Yee, Albert; Milner, Katrine; Kunz, Monica] Sunnybrook Hlth Sci Ctr, Toronto, ON, Canada.
[Schemitsch, Emil H.; Ahn, Henry; Hall, Jeremy A.; McKee, Michael D.; Whelan, Daniel B.; Nauth, Aaron; Vicente, Milena R.; Wild, Lisa M.; Khan, Ryan M.; Hidy, Jennifer T.] St Michaels Hosp, Toronto, ON, Canada.
[Coles, Chad; Leighton, Ross; Biddulph, Michael; Johnston, David; Glazebrook, Mark; Alexander, David; Coady, Cathy; Dunbar, Michael; Amirault, David; Gross, Michael; Oxner, William; Reardon, Gerald; Richardson, Glen; Trenholm, Andrew; Wong, Ivan; Trask, Kelly; MacDonald, Shelley; Dobbin, Gwen] Queen Elizabeth 2 Hlth Sci Ctr, Halifax, NS, Canada.
[Bicknell, Ryan; Yach, Jeff; Bardana, Davide; Wood, Gavin; Harrison, Mark; Yen, David; Lambert, Sue; Howells, Fiona; Ward, Angela] Queens Univ, Human Mobil Res Ctr, Kingston, ON K7L 3N6, Canada.
[Bicknell, Ryan; Yach, Jeff; Bardana, Davide; Wood, Gavin; Harrison, Mark; Yen, David; Lambert, Sue; Howells, Fiona; Ward, Angela] Kingston Gen Hosp, Kingston, ON, Canada.
[Zalzal, Paul; Brien, Heather; Naumetz, V.; Weening, Brad; Simunovic, Nicole] Oakville Trafalgar Mem Hosp, Oakville, ON, Canada.
[Wai, Eugene K.; Papp, Steve; Gofton, Wade T.; Liew, Allen; Kingwell, Stephen P.; Johnson, Garth; O'Neil, Joseph; Roffey, Darren M.; Borsella, Vivian] Ottawa Hosp, Ottawa, ON, Canada.
[Avram, Victoria] Juravinski Hosp & Canc Ctr, Hamilton, ON, Canada.
[Oliver, Todd M.; Jones, Vicki] Boone Hosp Ctr, Columbia Orthopaed Grp, Columbia, MO USA.
[Jones, Clifford B.; Ringler, James R.; Endres, Terrence J.; Sietsema, Debra L.] Orthopaed Associates Michigan, Grand Rapids, MI USA.
[Jeray, Kyle J.; Broderick, J. Scott; Goetz, David R.; Pace, Thomas B.; Schaller, Thomas M.; Porter, Scott E.; Tanner, Stephanie L.; Snider, Rebecca G.; Nastoff, Lauren A.; Bielby, Shea A.] Greenville Hosp Syst, Greenville, SC USA.
[Switzer, Julie A.; Cole, Peter A.; Anderson, Sarah A.; Lafferty, Paul M.; Li, Mengnai; Ly, Thuan V.; Marston, Scott B.; Foley, Amy L.; Vang, Sandy; Wright, David M.] Reg Hosp Univ Minnesota, Minneapolis, MN USA.
[Marcantonio, Andrew J.; Kain, Michael S. H.; Iorio, Richard; Specht, Lawrence M.; Tilzey, John F.; Lobo, Margaret J.; Garfi, John S.] Lahey Hosp & Med Ctr, Burlington, MA USA.
[Vallier, Heather A.; Dolenc, Andrea; Robinson, Chalitha] Metrohlth Med Ctr, Cleveland, OH USA.
[Prayson, Michael J.; Laughlin, Richard; Rubino, L. Joseph; May, Jedediah; Rieser, Geoffrey Ryan; Dulaney-Cripe, Liz; Gayton, Chris] Miami Valley Hosp, Dayton, OH USA.
[Shaer, James; Schrickel, Tyson; Hileman, Barbara] St Elizabeth Hlth Ctr, Youngstown, OH USA.
[Gorczyca, John T.; Gross, Jonathan M.; Humphrey, Catherine A.; Kates, Stephen; Noble, Krista; McIntyre, Allison W.; Pecorella, Kaili] Univ Rochester, Med Ctr, Rochester, NY 14627 USA.
[Davis, Craig A.; Weinerman, Stewart; Weingarten, Peter; Stull, Philip; Lindenbaum, Stephen; Hewitt, Michael; Schwappach, John; Baker, Janell K.; Rutherford, Tori; Newman, Heike; Lieberman, Shane; Finn, Erin; Robbins, Kristin; Hurley, Meghan; Lyle, Lindsey; Mitchell, Khalis; Browner, Kieran; Whatley, Erica; Payton, Krystal; Reeves, Christina] Colorado Orthoped Consultants, Aurora, CO USA.
[Cannada, Lisa K.; Karges, David; Hill, Leslie] St Louis Univ Hosp, St Louis, MO USA.
[Mehta, Samir; Esterhai, John; Ahn, Jaimo; Horan, Annamarie D.; McGinnis, Kelly; Kaminski, Christine A.; Kowalski, Brynn N.] Univ Penn, Philadelphia, PA 19104 USA.
[Keeve, Jonathan P.; Anderson, Christopher G.; McDonald, Michael D.; Hoffman, Jodi M.] Northwest Orthopaed Specialists, Spokane, WA USA.
[Tarkin, Ivan; Siska, Peter; Gruen, Gary; Evans, Andrew; Farrell, Dana J.; Irrgang, James; Luther, Arlene] Univ Pittsburgh, Med Ctr, Pittsburgh, PA 15260 USA.
[Cross, William W., III; Cass, Joseph R.; Sems, Stephen A.; Torchia, Michael E.; Scrabeck, Tyson] Mayo Clin, Scottsdale, AZ USA.
[Jenkins, Mark; Dumais, Jules; Romero, Amanda W.] Texas Tech Univ, Hlth Sci Ctr Lubbock, Lubbock, TX 79409 USA.
[Sagebien, Carlos A.; Butler, Mark S.; Monica, James T.; Seuffert, Patricia] Univ Orthopaed Associates LLC, Somerset, NJ USA.
[Hsu, Joseph R.; Ficke, James; Charlton, Michael; Napierala, Matthew; Fan, Mary] US Army, Inst Surg Res, New York, NY USA.
[Tornetta, Paul, III; Tannoury, Chadi; Carlisle, Hope; Silva, Heather] Boston Univ, Ctr Med, Boston, MA 02215 USA.
[Archdeacon, Michael; Finnan, Ryan; Le, Toan; Wyrick, John; Hess, Shelley] Univ Cincinnati, Ctr Med, UC Hlth, Cincinnati, OH 45221 USA.
[Brennan, Michael L.; Probe, Robert; Kile, Evelyn; Mills, Kelli; Clipper, Lydia; Yu, Michelle; Erwin, Katie] Scott & White Mem Hosp & Clin, Temple, TX 76508 USA.
[Horwitz, Daniel; Strohecker, Kent; Swenson, Teresa K.] Geisinger Med Ctr, Danville, PA USA.
Hennepin Cty Med Ctr, Minneapolis, MN USA.
[Aurang, Kamran; Zohman, Gary; Peterson, Brett; Huff, Roger B.] Kaiser Permanente, Sidney, BC, Canada.
[Baele, Joseph; Weber, Timothy; Edison, Matt] OrthoIndy, Fishers, IN USA.
[McBeth, Jessica] Santa Clara Valley Med Ctr, Santa Clara, CA USA.
[Shively, Karl; Ertl, Janos P.; Mullis, Brian; Parr, J. Andrew; Worman, Ripley; Frizzell, Valda; Moore, Molly M.; Tobias, Erin; Thomas, Emily] Indiana Univ, Wishard Hlth Serv, Bloomington, IN 47405 USA.
[DePaolo, Charles J.; Alosky, Rachel; Shell, Leslie E.; Hampton, Lynne; Shepard, Stephanie; Nanney, Tracy; Cuento, Claudine] Mission Hosp Res Inst, New York, NY USA.
[Cantu, Robert V.; Henderson, Eric R.; Eickhoff, Linda S.] Dartmouth Hitchcock Med Ctr, Lebanon, NH USA.
[Hammerberg, E. Mark; Stahel, Philip; Hak, David; Mauffrey, Cyril; Gibula, Douglas; Gissel, Hannah; Henderson, Corey] Denver Hlth & Hosp Author, Denver, CO USA.
[Zamorano, David P.; Tynan, Martin C.; Pourmand, Deeba; Lawson, Deanna] Univ Calif Irvine Med Ctr, Orange, CA USA.
[Della Rocca, Gregory J.; Crist, Brett D.; Murtha, Yvonne M.; Anderson, Linda K.] Univ Missouri Hlth Care, Columbia, MO USA.
[Linehan, Colleen; Pilling, Lindsey] Covenant Healthcare Saginaw, Saginaw, MI USA.
[Lewis, Courtland G.; Caminiti, Stephanie; Sullivan, Raymond J.; Roper, Elizabeth] Hartford Hosp, Hartford, CT USA.
[Obremskey, William; Kregor, Philip; Richards, Justin E.; Stringfellow, Kenya] Vanderbilt Univ, Med Ctr, Nashville, TN USA.
[Dohm, Michael P.; Zellar, Abby] Western Slope Study Grp, Grand Junction, CO USA.
[Segers, Michiel J. M.; Zijl, Jacco A. C.; Verhoeven, Bart; Smits, Anke B.; de Vries, Jean Paul P. M.; Fioole, Bram; van der Hoeven, Henk; Theunissen, Evert B. M.; Reilingh, Tammo S. de Vries; Govaert, Lonneke; Wittich, Philippe; de Brauw, Maurits; Wille, Jan; Go, Peter M. N. Y. M.; Ritchie, Ewan D.; Wessel, Ronald N.; Hammacher, Eric R.] St Antonius Hosp, Nieuwegein, Netherlands.
[Heetveld, Martin J.; Visser, Gijs A.; Stockmann, Heyn; Silvis, Rob; Snellen, Jaap P.; Rijbroek, Bram; Scheepers, Joris J. G.; Vermeulen, Erik G. J.; Siroen, Michiel P. C.; Vuylsteke, Ronald; Brom, Hans L. F.; Rijna, Herman] Kennemer Gasthuis, Haarlem, Netherlands.
[de Rijcke, Piet A. R.; Koppert, Cees L.; Buijk, Steven E.; Groenendijk, Richard P. R.; Dawson, Imro; Tetteroo, Geert W. M.; Bruijninckx, Milko M. M.; Doornebosch, Pascal G.; de Graaf, Eelco J. R.] IJsselland Ziekenhuis, Rotterdam, Netherlands.
[van der Elst, Maarten; van der Pol, Carmen C.; van 't Riet, Martijne; Karsten, Tom M.; de Vries, Mark R.; Stassen, Laurents P. S.; Schep, Niels W. L.; Ben Schmidt, G.; Hoffman, W. H.] Reinier de Graaf Gasthuis, Delft, Netherlands.
[Poolman, Rudolf W.; Simons, Maarten P.; van der Heijden, Frank H. W. M.; Willems, W. Jaap; de Meulemeester, Frank R. A. J.; van der Hart, Cor P.; Turckan, Kahn; Festen, Sebastiaan; de Nies, Frank; Haverlag, Robert; Out, Nico J. M.; Bosma, Jan] Onze Lieve Vrouw Hosp, Amsterdam, Netherlands.
[van Kampen, Albert; Biert, Jan; van Vugt, Arie B.; Edwards, Michael J. R.; Blokhuis, Taco J.; Frolke, Jan Paul M.; Geeraedts, Leo M. G.; Gardeniers, Jean W. M.; Tan, Edward T. C. H.; Poelhekke, Lodewijk M. S. J.; Malefijt, Maarten C. de Waal; Schreurs, Bart] Radboud Univ Nijmegen Med Ctr, Nijmegen, Netherlands.
[Roukema, Gert R.; Josaputra, Hong A.; Keller, Paul; de Rooij, Peter D.; Kuiken, Hans; Boxma, Han; Cleffken, Berry I.; Liem, Ronald] Maasstad Ziekenhuis, Rotterdam, Netherlands.
[Rhemrev, Steven J.; Bosman, Coks H. R.; van Otterloo, Alexander de Mol; Hoogendoorn, Jochem; de Vries, Alexander C.; Meylaerts, Sven A. G.] Med Ctr Haaglanden, The Hague, Netherlands.
[van der Heijden, Frank H. W. M.; Verhofstad, Michiel H. J.; Meijer, Joost; van Egmond, Teun; van der Brand, Igor] St Elizabeth Hosp, Tilburg, Netherlands.
[Patka, Peter; Eversdijk, Martin G.; Peters, Rolf; Den Hartog, Dennis; Van Waes, Oscar J. F.; Oprel, Pim] Univ Med Ctr Rotterdam, Erasmus MC, Rotterdam, Netherlands.
[van der Vis, Harm M.; Campo, Martin; Verhagen, Ronald; Albers, G. H. Robert; Zurcher, Arthur W.] Tergooi Ziekenhuizen, Hilversum, Netherlands.
[Blokhuis, Taco J.; Simmermacher, Rogier K. J.; van Mulken, Jeroen; van Wessem, Karlijn; van Gaalen, Steven M.; Leenen, Luke P. H.] Univ Med Ctr Utrecht, Utrecht, Netherlands.
[Bronkhorst, Maarten W. G. A.; Guicherit, Onno R.] Bronovo Ziekenhuis, The Hague, Netherlands.
[Haverlag, Robert; Goslings, J. Carel; Ponsen, Kees Jan] Acad Med Ctr, Amsterdam, Netherlands.
[Bhatia, Mahesh; Arora, Vinod; Tyagi, Vivek] RLB Hosp & Res Ctr, Indore, Madhya Pradesh, India.
[Liew, Susan; Bedi, Harvinder; Carr, Ashley; Curry, Hamish; Chia, Andrew; Csongvay, Steve; Donohue, Craig; Doig, Stephen; Edwards, Elton; Etherington, Greg; Esser, Max; Gong, Andrew; Jain, Arvind; Li, Doug; Miller, Russell; Moaveni, Ash; Russ, Matthias; Ton, Lu; Wang, Otis; Dowrick, Adam; Murdoch, Zoe; Sage, Claire] The Alfred, Melbourne, Vic, Australia.
[Frihagen, Frede; Clarke-Jenssen, John; Hjorthaug, Geir; Ianssen, Torben; Amundsen, Asgeir; Brattgjerd, Jan Egil; Borch, Tor; Boe, Berthe; Flatoy, Bernhard; Hasselund, Sondre; Haug, Knut Jorgen; Hemlock, Kim; Hoseth, Tor Magne; Jomaas, Geir; Kibsgard, Thomas; Lona, Tarjei; Moatshe, Gilbert; Muller, Oliver; Molund, Marius; Nicolaisen, Tor; Nilsen, Fredrik; Rydinge, Jonas; Smedsrud, Morten; Stodle, Are; Trommer, Axel; Ugland, Stein; Karlsten, Anders; Ekas, Guri; Vesterhus, Elise Berg; Brekke, Anne Christine] Oslo Univ Hosp, Oslo, Norway.
[Gupta, Ajay; Jain, Neeraj; Khan, Farah] Nirmal Hosp, Surat, India.
[Sharma, Ateet; Sanghavi, Amir; Trivedi, Mittal] Satellite Orthopaed Hosp & Res Ctr, Ahmadabad, Gujarat, India.
[Rai, Anil; Subash; Rai, Kamal] Highway Hosp, Lucknow, Uttar Pradesh, India.
[Rai, Kamal; Yadav, Vineet; Singh, Sanjay] Popular Hosp, Varanasi, Uttar Pradesh, India.
[Tetsworth, Kevin; Donald, Geoff; Weinrauch, Patrick; Pincus, Paul; Yang, Steven; Halliday, Brett; Gervais, Trevor; Holt, Michael; Flynn, Annette] Royal Brisbane & Womens Hosp, Brisbane, Qld, Australia.
[Prasad, Amal Shankar; Mishra, Vimlesh] Madhuraj Nursing Home, Kanpur, Uttar Pradesh, India.
[Sundaresh, D. C.; Khanna, Angshuman] MS Rammaiah Med Coll & Hosp, Bangalore, Karnataka, India.
[Cherian, Joe Joseph; Olakkengil, Davy J.; Sharma, Gaurav] St Johns Med Coll Hosp, Bangalore, Karnataka, India.
[Pirpiris, Marinis; Love, David; Bucknill, Andrew; Farrugia, Richard J.] Royal Melbourne Hosp, Melbourne, Vic, Australia.
[Pape, Hans-Christoph; Knobe, Matthias; Pfeifer, Roman] Univ Aachen, Med Ctr, Aachen, Germany.
[Hull, Peter; Lewis, Sophie; Evans, Simone] Cambridge Univ Hosp, Cambridge, England.
[Nanda, Rajesh; Logishetty, Rajanikanth; Anand, Sanjeev; Bowler, Carol] Univ Hosp North Tees, Cleveland, England.
[Dadi, Akhil; Palla, Naveen; Ganguly, Utsav] Sunshine Hosp, Hyderabad, Andhra Pradesh, India.
[Rai, B. Sachidananda; Rajakumar, Janakiraman] Unity Hlth Complex, Mangaluru, Karnataka, India.
[Jennings, Andrew; Chuter, Graham; Rose, Glynis; Horner, Gillian] Univ Hosp North Durham, Durham, England.
[Jennings, Andrew; Chuter, Graham; Rose, Glynis; Horner, Gillian] Darlington Mem Hosp, Darlington, Durham, England.
[Clark, Callum; Eke, Kate] Wexham Pk Hosp, Slough, Berks, England.
[Reed, Mike; Herriott, Chris; Dobb, Christine] Northumbria Healthcare NHS Fdn Trust, Newcastle Upon Tyne, Tyne & Wear, England.
[Simunovic, Nicole; Maddock, Deborah] McMaster Univ, Hamilton, ON L8S 4L8, Canada.
[Agel, Julie] Univ Minnesota, Minneapolis, MN 55455 USA.
[Zielinski, Stephanie M.] Univ Med Ctr Rotterdam, Erasmus MC, Rotterdam, Netherlands.
[Hanusch, Birgit C.; Kottam, Lucksy; Clarkson, Rachel] James Cook Univ Hosp, Middlesbrough, Cleveland, England.
RP McCormack, R (reprint author), McMaster Univ, Div Orthopaed Surg, 293 Wellington St North,Suite 110, Hamilton, ON L8L 8E7, Canada.
EM bhandam@mcmaster.ca
RI CSTFA, ResearcherID/P-1067-2014; Biert, J./L-4200-2015; Kampen,
A./H-8056-2014; Frolke, J.P.M./L-4312-2015; Schreurs, B.W./L-4639-2015
FU Canadian Institutes of Health Research (CIHR); National Institutes of
Health (NIH); Stichting NutsOhra; Netherlands Organisation for Health
Research and Development; Physicians' Services Incorporated; Canada
Research Chair in Musculoskeletal Trauma; County Durham & Tees Valley
Comprehensive Local Research Network
FX Research grants were received from the following: Canadian Institutes of
Health Research (CIHR) (PI: Mohit Bhandari); National Institutes of
Health (NIH) (PI: Marc Swiontkowski); Stichting NutsOhra (PI: Martin J
Heetveld), The Netherlands Organisation for Health Research and
Development (PI: Esther M M Van Lieshout); Physicians' Services
Incorporated (PI: Mohit Bhandari). Dr. Bhandari was also funded, in
part, by a Canada Research Chair in Musculoskeletal Trauma which is
unrelated to the present study (McMaster University, Hamilton, ON,
Canada). We would also like to acknowledge the support of The County
Durham & Tees Valley Comprehensive Local Research Network which operates
as part of the National Institute for Health Research Comprehensive
Clinical Research Network in England. The funding sources and study
sponsor had no role in design or conduct of the study; the collection,
management, analysis, or interpretation of the data; or writing of the
report or the decision to submit the report for publication. Dr. Mohit
Bhandari had full access to all of the data in the study and takes
responsibility for the integrity of the data and the accuracy of the
data analysis.
NR 53
TC 0
Z9 0
U1 3
U2 19
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1471-2474
J9 BMC MUSCULOSKEL DIS
JI BMC Musculoskelet. Disord.
PD JUN 26
PY 2014
VL 15
AR 219
DI 10.1186/1471-2474-15-219
PG 15
WC Orthopedics; Rheumatology
SC Orthopedics; Rheumatology
GA AO6KG
UT WOS:000341459200001
ER
PT J
AU Chen, J
Pan, HN
Chen, C
Wu, W
Iskandar, K
He, J
Piermartiri, T
Jacobowitz, DM
Yu, QS
McDonough, JH
Greig, NH
Marini, AM
AF Chen, Jun
Pan, Hongna
Chen, Cynthia
Wu, Wei
Iskandar, Kevin
He, Jeffrey
Piermartiri, Tetsade
Jacobowitz, David M.
Yu, Qian-Sheng
McDonough, John H.
Greig, Nigel H.
Marini, Ann M.
TI (-)-Phenserine Attenuates Soman-Induced Neuropathology
SO PLOS ONE
LA English
DT Article
ID AMYLOID PRECURSOR PROTEIN; SUBWAY SARIN ATTACK;
POSTTRAUMATIC-STRESS-DISORDER; ORGANOPHOSPHORUS NERVE AGENTS;
ALZHEIMERS-DISEASE; INDUCED SEIZURES; ACETYLCHOLINESTERASE INHIBITION;
CHOLINESTERASE-INHIBITORS; TRANSCRIPTION FACTOR; NEURONAL SURVIVAL
AB Organophosphorus (OP) nerve agents are deadly chemical weapons that pose an alarming threat to military and civilian populations. The irreversible inhibition of the critical cholinergic degradative enzyme acetylcholinesterase (AChE) by OP nerve agents leads to cholinergic crisis. Resulting excessive synaptic acetylcholine levels leads to status epilepticus that, in turn, results in brain damage. Current countermeasures are only modestly effective in protecting against OP-induced brain damage, supporting interest for evaluation of new ones. (-)-Phenserine is a reversible AChE inhibitor possessing neuroprotective and amyloid precursor protein lowering actions that reached Phase III clinical trials for Alzheimer's Disease where it exhibited a wide safety margin. This compound preferentially enters the CNS and has potential to impede soman binding to the active site of AChE to, thereby, serve in a protective capacity. Herein, we demonstrate that (-)-phenserine protects neurons against soman-induced neuronal cell death in rats when administered either as a pretreatment or post-treatment paradigm, improves motoric movement in soman-exposed animals and reduces mortality when given as a pretreatment. Gene expression analysis, undertaken to elucidate mechanism, showed that (-)-phenserine pretreatment increased select neuroprotective genes and reversed a Homer1expression elevation induced by soman exposure. These studies suggest that (-)-phenserine warrants further evaluation as an OP nerve agent protective strategy.
C1 [Chen, Jun; Pan, Hongna; Chen, Cynthia; Wu, Wei; Iskandar, Kevin; He, Jeffrey; Piermartiri, Tetsade; Marini, Ann M.] Uniformed Serv Univ Hlth Sci, Dept Neurol, Bethesda, MD 20814 USA.
[Jacobowitz, David M.] Uniformed Serv Univ Hlth Sci, Dept Anat Physiol & Genet, Bethesda, MD 20814 USA.
[Yu, Qian-Sheng; Greig, Nigel H.] NIA, Drug Design & Dev Sect, Translat Gerontol Branch, Intramural Res Program,NIH, Baltimore, MD 21224 USA.
[McDonough, John H.] US Army Med Res Inst Chem Def, Pharmacol Branch, Div Res, Aberdeen Proving Ground, MD USA.
RP Marini, AM (reprint author), Uniformed Serv Univ Hlth Sci, Dept Neurol, Bethesda, MD 20814 USA.
EM ann.marini@usuhs.edu
OI Piermartiri, Tetsade/0000-0002-9773-6983
FU Defense Threat Reduction Agency-Joint Science and Technology Office,
Medical ST Division [CBM.NEURO.01.10.US.012, CBM.NEURO.01.10.US.019];
Intramural Research Program, National Institute on Aging, National
Institutes of Health
FX This work was supported by Defense Threat Reduction Agency-Joint Science
and Technology Office, Medical S&T Division [Grant Numbers
CBM.NEURO.01.10.US.012 and CBM.NEURO.01.10.US.019] (AMM); Intramural
Research Program, National Institute on Aging, National Institutes of
Health (NHG). The funders had no role in study design, data collection
and analysis, decision to publish, or preparation of the manuscript.
NR 88
TC 3
Z9 4
U1 0
U2 10
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD JUN 23
PY 2014
VL 9
IS 6
AR e99818
DI 10.1371/journal.pone.0099818
PG 12
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA AL1WV
UT WOS:000338917900019
PM 24955574
ER
PT J
AU Sablon, K
Little, J
Vagidov, N
Li, Y
Mitin, V
Sergeev, A
AF Sablon, K.
Little, J.
Vagidov, N.
Li, Y.
Mitin, V.
Sergeev, A.
TI Conversion of above- and below-bandgap photons via InAs quantum dot
media embedded into GaAs solar cell
SO APPLIED PHYSICS LETTERS
LA English
DT Article
ID EFFICIENCY; ENERGY; NANOCRYSTALS; IMPROVEMENT; DEPENDENCE; CHARGE
AB Quantum dots (QDs) provide photovoltaic conversion of below-bandgap photons due to multistep electron transitions. QDs also increase conversion efficiency of the above-bandgap photons due to extraction of electrons from QDs via Coulomb interaction with hot electrons excited by high-energy photons. Nanoscale potential profile (potential barriers) and nanoscale band engineering (AlGaAs atomically thin barriers) allow for suppression of photoelectron capture to QDs. To study these kinetic effects and to distinguish them from the absorption enhancement due to light scattering on QDs, we investigate long, 3-mu m base GaAs devices with various InAs QD media with 20 and 40 QD layers. Quantum efficiency measurements show that, at least at low doping, the multistep processes in QD media are strongly affected by the wetting layer (WL). The QD media with WLs provide substantial conversion of below-bandgap photons and for devices with 40 QD layers the short circuit current reaches 29.2 mA/cm(2). The QD media with band-engineered AlGaAs barriers and reduced wetting layers (RWL) enhance conversion of high-energy photons and decrease the relaxation (thermal) losses. (C) 2014 AIP Publishing LLC.
C1 [Sablon, K.; Little, J.] US Army Res Lab, Adelphi, MD 20783 USA.
[Vagidov, N.] Optoelect Nanodevices LLC, Amherst, NY 14226 USA.
[Li, Y.; Mitin, V.; Sergeev, A.] SUNY Buffalo, EE Dept, Buffalo, NY 14260 USA.
RP Sablon, K (reprint author), US Army Res Lab, Adelphi, MD 20783 USA.
FU ARL; AFRL [FA9453-14-M-0013]; NSF [ECS-1236459]; AFOSR
[FA9550-10-1-0391]
FX The work of K. S. and J.L. was supported by ARL, work of N.V. by AFRL
(FA9453-14-M-0013), work of Y. Li and A. S. by NSF (ECS-1236459), and
work of V. M. by AFOSR (FA9550-10-1-0391). The authors are grateful to
D. Wilt and S. Oktyabrsky for valuable discussions and highly appreciate
Michael Yakimov's help in SIMS and EDXS analyses of our devices.
NR 25
TC 11
Z9 11
U1 1
U2 25
PU AMER INST PHYSICS
PI MELVILLE
PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1,
MELVILLE, NY 11747-4501 USA
SN 0003-6951
EI 1077-3118
J9 APPL PHYS LETT
JI Appl. Phys. Lett.
PD JUN 23
PY 2014
VL 104
IS 25
AR 253904
DI 10.1063/1.4885113
PG 5
WC Physics, Applied
SC Physics
GA AK6CQ
UT WOS:000338515900101
ER
PT J
AU Tschopp, MA
Gao, F
Solanki, KN
AF Tschopp, M. A.
Gao, F.
Solanki, K. N.
TI Binding of HenV clusters to alpha-Fe grain boundaries
SO JOURNAL OF APPLIED PHYSICS
LA English
DT Article
ID HELIUM-VACANCY CLUSTERS; MOLECULAR-DYNAMICS; BCC IRON; DISPLACEMENT
CASCADES; STRUCTURAL-MATERIALS; DEFECT PRODUCTION; TENSILE-STRENGTH;
ENERGY; FUSION; IRRADIATION
AB The objective of this research is to explore the formation/binding energetics and length scales associated with the interaction between HenV clusters and grain boundaries in bcc alpha-Fe. In this work, we calculated formation/binding energies for 1-8 He atoms in a monovacancy at all potential grain boundary (GB) sites within 15 angstrom of the ten grain boundaries selected (122106 simulations total). The present results provide detailed information about the interaction energies and length scales of 1-8 He atoms with grain boundaries for the structures examined. A number of interesting new findings emerge from the present study. First, the Sigma 3(112) "twin" GB has significantly lower binding energies for all HenV clusters than all other boundaries in this study. For all grain boundary sites, the effect of the local environment surrounding each site on the HenV formation and binding energies decreases with an increasing number of He atoms in the HenV cluster. Based on the calculated dataset, we formulated a model to capture the evolution of the formation and binding energy of HenV clusters as a function of distance from the GB center, utilizing only constants related to the maximum binding energy and the length scale. (C) 2014 AIP Publishing LLC.
C1 [Tschopp, M. A.] US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA.
[Gao, F.] Pacific NW Natl Lab, Richland, WA 99352 USA.
[Solanki, K. N.] Arizona State Univ, Tempe, AZ 85287 USA.
RP Tschopp, MA (reprint author), US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA.
EM mark.a.tschopp.civ@mail.mil
RI Solanki, Kiran/E-8337-2010;
OI Tschopp, Mark/0000-0001-8471-5035
FU U.S. Army Research Laboratory (ARL); U.S. Department of Energy, Office
of Fusion Energy Science [DE-AC06-76RLO 1830]; Alternate Sponsored
Fellowship (ASF) at PNNL
FX This work was supported in part by the U.S. Army Research Laboratory
(ARL). F. G. is grateful for the support by the U.S. Department of
Energy, Office of Fusion Energy Science, under Contract DE-AC06-76RLO
1830. The authors would like to acknowledge the support and discussions
with Dr. Xin Sun at Pacific Northwest National Laboratory. Last, the
authors would like to acknowledge Ms. Joanna Sun, a high school student
support by the Alternate Sponsored Fellowship (ASF) at PNNL, for her
contributions to this work.
NR 83
TC 5
Z9 5
U1 4
U2 37
PU AMER INST PHYSICS
PI MELVILLE
PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1,
MELVILLE, NY 11747-4501 USA
SN 0021-8979
EI 1089-7550
J9 J APPL PHYS
JI J. Appl. Phys.
PD JUN 21
PY 2014
VL 115
IS 23
AR 233501
DI 10.1063/1.4883357
PG 15
WC Physics, Applied
SC Physics
GA AK0MB
UT WOS:000338106000009
ER
PT J
AU Liu, RF
Singh, N
Tawa, GJ
Wallqvist, A
Reifman, J
AF Liu, Ruifeng
Singh, Narender
Tawa, Gregory J.
Wallqvist, Anders
Reifman, Jaques
TI Exploiting large-scale drug-protein interaction information for
computational drug repurposing
SO BMC BIOINFORMATICS
LA English
DT Article
DE Drug repurposing; Bayes theorem; Drug-protein interaction; Mechanism of
drug action
ID PLASMODIUM-FALCIPARUM; CEREBRAL MALARIA; MULTIPLE-MYELOMA;
DEXAMETHASONE; THALIDOMIDE; PARASITE; IDENTIFICATION; MECHANISMS;
HEMORRHAGE; RESISTANCE
AB Background: Despite increased investment in pharmaceutical research and development, fewer and fewer new drugs are entering the marketplace. This has prompted studies in repurposing existing drugs for use against diseases with unmet medical needs. A popular approach is to develop a classification model based on drugs with and without a desired therapeutic effect. For this approach to be statistically sound, it requires a large number of drugs in both classes. However, given few or no approved drugs for the diseases of highest medical urgency and interest, different strategies need to be investigated.
Results: We developed a computational method termed "drug-protein interaction-based repurposing" (DPIR) that is potentially applicable to diseases with very few approved drugs. The method, based on genome-wide drug-protein interaction information and Bayesian statistics, first identifies drug-protein interactions associated with a desired therapeutic effect. Then, it uses key drug-protein interactions to score other drugs for their potential to have the same therapeutic effect.
Conclusions: Detailed cross-validation studies using United States Food and Drug Administration-approved drugs for hypertension, human immunodeficiency virus, and malaria indicated that DPIR provides robust predictions. It achieves high levels of enrichment of drugs approved for a disease even with models developed based on a single drug known to treat the disease. Analysis of our model predictions also indicated that the method is potentially useful for understanding molecular mechanisms of drug action and for identifying protein targets that may potentiate the desired therapeutic effects of other drugs (combination therapies).
C1 [Liu, Ruifeng; Singh, Narender; Tawa, Gregory J.; Wallqvist, Anders; Reifman, Jaques] US Army, Med Res & Mat Command, Telemed & Adv Technol Res Ctr, Software Applicat Inst,Dept Def Biotechnol High P, Ft Detrick, MD 21702 USA.
RP Liu, RF (reprint author), US Army, Med Res & Mat Command, Telemed & Adv Technol Res Ctr, Software Applicat Inst,Dept Def Biotechnol High P, Ft Detrick, MD 21702 USA.
EM RLiu@bhsai.org; AWallqvist@bhsai.org
OI wallqvist, anders/0000-0002-9775-7469
FU U.S. Army Medical Research and Materiel Command (Ft. Detrick, MD), as
part of the U.S. Army's Network Science Initiative
FX The authors were supported by the U.S. Army Medical Research and
Materiel Command (Ft. Detrick, MD), as part of the U.S. Army's Network
Science Initiative. The opinions and assertions contained herein are the
private views of the authors and are not to be construed as official or
as reflecting the views of the U.S. Army or of the U.S. Department of
Defense. This paper has been approved for public release with unlimited
distribution.
NR 51
TC 6
Z9 6
U1 1
U2 10
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1471-2105
J9 BMC BIOINFORMATICS
JI BMC Bioinformatics
PD JUN 20
PY 2014
VL 15
AR 210
DI 10.1186/1471-2105-15-210
PG 16
WC Biochemical Research Methods; Biotechnology & Applied Microbiology;
Mathematical & Computational Biology
SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology;
Mathematical & Computational Biology
GA AK2QM
UT WOS:000338264200002
PM 24950817
ER
PT J
AU Faraone, A
Fratini, E
Garai, S
Muller, A
Tyagi, M
Jenkins, T
Mamontov, E
Paul, RL
Copley, JRD
Baglioni, P
AF Faraone, Antonio
Fratini, Emiliano
Garai, Somenath
Mueller, Achim
Tyagi, Madhusudan
Jenkins, Timothy
Mamontov, Eugene
Paul, Rick L.
Copley, John R. D.
Baglioni, Piero
TI Incoherent Quasielastic Neutron Scattering Study of the Relaxation
Dynamics in Molybdenum-Oxide Keplerate-Type Nanocages
SO JOURNAL OF PHYSICAL CHEMISTRY C
LA English
DT Article
ID METHYL-GROUP DYNAMICS; HYDRATION WATER DYNAMICS; SINGLE-PARTICLE
DYNAMICS; HYDROGEN-BONDED LIQUIDS; MOLECULAR-DYNAMICS; SUPERCOOLED
WATER; MESOSCOPIC CONFINEMENT; ENCAPSULATED WATER; DIFFUSIVE MOTIONS;
INTERNAL DYNAMICS
AB The single-particle relaxation dynamics of hydrogen atoms in different oxomolybdate Keplerate-type nanocages characterized by a (metal)(30) icosahedron and a size of approximate to 2.5 nm were studied using incoherent quasielastic neutron scattering. Measurements were performed on a compound with a {Mo72Cr30} nanocage containing internal acetate ligands and a sodium cation coordinated to 12 water molecules. Because of the presence of the methyl groups of the acetate ligands, the related cavity is mostly hydrophobic and represents an interesting model system for investigating the properties of water molecules under confined conditions in contact with hydrophobic surfaces. The single-particle dynamics of both the methyl groups and the water molecules inside the cavity were studied and characterized to. be thermally activated processes. The volume explored by the hydrogen atoms during their motions was also determined. Elastic scan measurements of the {Mo72Cr30} cage, in comparison with the {Mo72V30} cage, which has the same skeletal structure as {Mo72Cr30} but a hydrophilic interior, have allowed an investigation into the vibrational dynamics of the cages themselves and the determination of the effect of the cage polarity.
C1 [Faraone, Antonio; Tyagi, Madhusudan; Jenkins, Timothy; Copley, John R. D.] NIST, Ctr Neutron Res, Gaithersburg, MD 20899 USA.
[Faraone, Antonio; Tyagi, Madhusudan] Univ Maryland, Dept Mat Sci & Engn, College Pk, MD 20742 USA.
[Fratini, Emiliano; Baglioni, Piero] Univ Florence, Dept Chem Ugo Schiff, I-50019 Florence, Italy.
[Fratini, Emiliano; Baglioni, Piero] Univ Florence, CSGI, I-50019 Florence, Italy.
[Garai, Somenath; Mueller, Achim] Univ Bielefeld, Fak Chem, D-33615 Bielefeld, Germany.
[Paul, Rick L.] NIST, Mat Measurement Lab, Div Analyt Chem, Gaithersburg, MD 20899 USA.
[Jenkins, Timothy] US Army Res Lab, Adelphi, MD 21005 USA.
[Mamontov, Eugene] Oak Ridge Natl Lab, Spallat Neutron Source, Oak Ridge, TN 37831 USA.
RP Faraone, A (reprint author), NIST, Ctr Neutron Res, 100 Bur Dr, Gaithersburg, MD 20899 USA.
EM antonio.faraone@nist.gov; piero.baglioni@unifi.it
RI Tyagi, Madhu Sudan/M-4693-2014; Mamontov, Eugene/Q-1003-2015; Baglioni,
Piero/B-1208-2011;
OI Tyagi, Madhu Sudan/0000-0002-4364-7176; Mamontov,
Eugene/0000-0002-5684-2675; Baglioni, Piero/0000-0003-1312-8700; Muller,
Achim/0000-0003-0117-4021
FU ERC (Brussels); National Science Foundation [DMR-0944772]; Scientific
User Facilities Division, Office of Basic Energy Sciences, U.S.
Department of Energy (DOE); Consorzio Interuniversitario per lo Sviluppo
dei Sistemi a Grande Interfase, CSGI; Minister dell'Istruzione,
Universita e della Ricerca Scientifica, MiUR
FX We thank Dr. A.M. Todea for initial experiments. The authors are
indebted to Dr. R. Bindel for performing some of the PGAA measurements.
A.M. thanks the ERC (Brussels) for an Advanced Grant. This work utilized
facilities supported in part by the National Science Foundation under
Agreement No. DMR-0944772. The neutron scattering experiments at Oak
Ridge National Laboratory's (ORNL) Spallation Neutron Source were
supported by the Scientific User Facilities Division, Office of Basic
Energy Sciences, U.S. Department of Energy (DOE). E.F. and P.B.
acknowledge financial support from Consorzio Interuniversitario per lo
Sviluppo dei Sistemi a Grande Interfase, CSGI, and Minister
dell'Istruzione, Universita e della Ricerca Scientifica, MiUR.
NR 70
TC 3
Z9 3
U1 2
U2 31
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 1932-7447
J9 J PHYS CHEM C
JI J. Phys. Chem. C
PD JUN 19
PY 2014
VL 118
IS 24
BP 13300
EP 13312
DI 10.1021/jp504547z
PG 13
WC Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science,
Multidisciplinary
SC Chemistry; Science & Technology - Other Topics; Materials Science
GA AJ6FA
UT WOS:000337783900078
ER
PT J
AU Brennan, JK
Lisal, M
Moore, JD
Izvekov, S
Schweigert, IV
Larentzos, JP
AF Brennan, John K.
Lisal, Martin
Moore, Joshua D.
Izvekov, Sergei
Schweigert, Igor V.
Larentzos, James P.
TI Coarse-Grain Model Simulations of Nonequilibrium Dynamics in
Heterogeneous Materials
SO JOURNAL OF PHYSICAL CHEMISTRY LETTERS
LA English
DT Article
ID DISSIPATIVE PARTICLE DYNAMICS; ENERGY-CONSERVATION; MOLECULAR-DYNAMICS;
DETONATION; SYSTEMS; COMBUSTION; ALGORITHMS; MIXTURES; SHOCK; RDX
AB A suite of computational tools is described for particle-based mesoscale simulations of the nonequilibrium dynamics of energetic solids, including mechanical deformation, phase transitions, and chemical reactivity triggered by shock or thermal loading. The method builds upon our recent advances both in generating coarse-grain models under high strains and in developing a variant of dissipative particle dynamics (DPD) that includes chemical reactions. To describe chemical reactivity, a coarse-grain particle equation-of-state was introduced into the constant-energy DPD variant that rigorously treats complex chemical reactions and the associated chemical energy release. As illustration of these developments, we present simulations of shock compression of an RDX crystal and its thermal decomposition under high temperatures. We also discuss our current efforts toward a highly scalable domain-decomposition implementation that extends applicability to micrometer-size simulations. With appropriate parametrization, the method is applicable to other materials whose dynamic response is driven by microstructural heterogeneities.
C1 [Brennan, John K.; Moore, Joshua D.; Izvekov, Sergei] US Army Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA.
[Lisal, Martin] ASCR, Inst Chem Proc Fundamentals, Lab Chem & Phys Aerosols, Vvi, Prague 16502, Czech Republic.
[Lisal, Martin] Univ JE Purkyne, Fac Sci, Dept Phys, Usti Nad Labem 40096, Czech Republic.
[Schweigert, Igor V.] US Naval Res Lab, Theoret Chem Sect, Washington, DC 20375 USA.
[Larentzos, James P.] US Army Res Lab, Engil Corp, High Performance Technol Grp, Aberdeen Proving Ground, MD 21005 USA.
RP Brennan, JK (reprint author), US Army Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA.
EM john.k.brennan.civ@mail.mil
RI Lisal, Martin/A-8176-2011; Schweigert, Igor/B-5750-2008
OI Lisal, Martin/0000-0001-8005-7143;
FU Office of Naval Research; Department of Defense; ARL [W911NF-10-2-0039];
Czech Science Foundation [13-02938S]
FX The authors acknowledge various scientists for insightful and
stimulating discussions, namely, Jean-Bernard Maillet (Commissariat a
l'energie atomique et aux energies alternatives, DAM), Gabriel Stoltz
(CERMICS-Ecole des Ponts Paris Tech), Timothy W. Sirk, William D.
Mattson, Michael S. Sellers, and Betsy M. Rice (U.S. Army Research
Laboratory). The authors also acknowledge financial support from various
sources, including the Office of Naval Research, the Department of
Defense High Performance Computing Modernization Program Software
Application Institute for Multiscale Reactive Modeling of Insensitive
Munitions, ARL under Cooperative Agreement W911NF-10-2-0039, and the
Czech Science Foundation under Project 13-02938S. Computer time was
partially provided by the METACentrum computing facility.
NR 44
TC 15
Z9 15
U1 7
U2 72
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 1948-7185
J9 J PHYS CHEM LETT
JI J. Phys. Chem. Lett.
PD JUN 19
PY 2014
VL 5
IS 12
BP 2144
EP 2149
DI 10.1021/jz500756s
PG 6
WC Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science,
Multidisciplinary; Physics, Atomic, Molecular & Chemical
SC Chemistry; Science & Technology - Other Topics; Materials Science;
Physics
GA AJ7IJ
UT WOS:000337870100016
PM 26270506
ER
PT J
AU Edmonds, JM
Sabol, JP
Rastogi, VK
AF Edmonds, Jason M.
Sabol, Jonathan P.
Rastogi, Vipin K.
TI Decontamination Efficacy of Three Commercial-Off-The-Shelf (COTS)
Sporicidal Disinfectants on Medium-Sized Panels Contaminated with
Surrogate Spores of Bacillus anthracis
SO PLOS ONE
LA English
DT Article
ID CHLORINE DIOXIDE GAS; SURFACES; THURINGIENSIS
AB In the event of a wide area release and contamination of a biological agent in an outdoor environment and to building exteriors, decontamination is likely to consume the Nation's remediation capacity, requiring years to cleanup, and leading to incalculable economic losses. This is in part due to scant body of efficacy data on surface areas larger than those studied in a typical laboratory (5x10-cm), resulting in low confidence for operational considerations in sampling and quantitative measurements of prospective technologies recruited in effective cleanup and restoration response. In addition to well-documented fumigation-based cleanup efforts, agencies responsible for mitigation of contaminated sites are exploring alternative methods for decontamination including combinations of disposal of contaminated items, source reduction by vacuuming, mechanical scrubbing, and low-technology alternatives such as pH-adjusted bleach pressure wash. If proven effective, a pressure wash-based removal of Bacillus anthracis spores from building surfaces with readily available equipment will significantly increase the readiness of Federal agencies to meet the daunting challenge of restoration and cleanup effort following a wide-area biological release. In this inter-agency study, the efficacy of commercial-of-the-shelf sporicidal disinfectants applied using backpack sprayers was evaluated in decontamination of spores on the surfaces of medium-sized (similar to 1.2 m(2)) panels of steel, pressure-treated (PT) lumber, and brick veneer. Of the three disinfectants, pH-amended bleach, Peridox, and CASCAD evaluated; CASCAD was found to be the most effective in decontamination of spores from all three panel surface types.
C1 [Edmonds, Jason M.; Rastogi, Vipin K.] US Army, Edgewood Chem Biol Ctr, Res Dev & Engn Command, Aberdeen Proving Ground, MD 21005 USA.
[Sabol, Jonathan P.] EXCET Inc, Springfield, VA USA.
RP Rastogi, VK (reprint author), US Army, Edgewood Chem Biol Ctr, Res Dev & Engn Command, Aberdeen Proving Ground, MD 21005 USA.
EM vipin.k.rastogi.civ@mail.mil
FU Joint Science and Technology Office of the Defense Threat Reduction
Agency
FX Funding for this program was provided by the Joint Science and
Technology Office of the Defense Threat Reduction Agency. The funders
had no role in study design, data collection and analysis, decision to
publish, or preparation of the manuscript.
NR 16
TC 0
Z9 0
U1 2
U2 8
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD JUN 18
PY 2014
VL 9
IS 6
AR e99827
DI 10.1371/journal.pone.0099827
PG 8
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA AK6AC
UT WOS:000338508200044
PM 24940605
ER
PT J
AU Peela, NR
Sutton, JE
Lee, IC
Vlachos, DG
AF Peela, Nageswara Rao
Sutton, Jonathan E.
Lee, Ivan C.
Vlachos, Dionisios G.
TI Microkinetic Modeling of Ethane Total Oxidation on Pt
SO INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
LA English
DT Article
ID DENSITY-FUNCTIONAL THEORY; NOBLE-METAL CATALYSTS; LOW-TEMPERATURE;
CHEMISORBED OXYGEN; PROPANE OXIDATION; CO OXIDATION; LEAN METHANE; AIR
MIXTURES; ALKANES; COMBUSTION
AB Catalytic total oxidation is important in several applications. However, associated models are rather empirical. In this study, a microkinetic model is developed for ethane total oxidation, under fuel-lean conditions on a Pt catalyst using input from density functional theory and Bronsted-Evans-Polanyi linear free energy relations. Reaction orders and the apparent activation energy estimated from the model are in good agreement with experimental values. The inclusion of oxygen coverage effects on the activation of ethane changes the rate-determining step from thermal dehydrogenation to oxidative dehydrogenation of ethane. A significant portion (30%) of the reaction flux proceeds via oxygen insertion reactions to C-2 hydrocarbons (CH2C*).
C1 [Peela, Nageswara Rao; Sutton, Jonathan E.; Vlachos, Dionisios G.] Univ Delaware, Dept Chem & Biomol Engn, Ctr Catalyt Sci & Technol, Newark, DE 19716 USA.
[Peela, Nageswara Rao; Sutton, Jonathan E.; Vlachos, Dionisios G.] Univ Delaware, Catalysis Ctr Energy Innovat, Newark, DE 19716 USA.
[Lee, Ivan C.] US Army Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA.
RP Vlachos, DG (reprint author), Univ Delaware, Dept Chem & Biomol Engn, Ctr Catalyt Sci & Technol, 150 Acad St, Newark, DE 19716 USA.
EM vlachos@udel.edu
OI Vlachos, Dionisios/0000-0002-6795-8403
FU Army Research Laboratory; National Science Foundation [CBET-940768]
FX Part of this research was sponsored by the Army Research Laboratory and
was accomplished under Cooperative Agreement Number W911NF-10-2-0047.
The views and conclusions contained in this document are those of the
authors and should not be interpreted as representing the official
policies, either expressed or implied, of the Army Research Laboratory
or the U.S. Government. The U.S. Government is authorized to reproduce
and distribute reprints for Government purposes notwithstanding any
copyright notation hereon. J.E. Sutton's work was supported by the
National Science Foundation (Award No. CBET-940768).
NR 47
TC 3
Z9 3
U1 0
U2 37
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0888-5885
J9 IND ENG CHEM RES
JI Ind. Eng. Chem. Res.
PD JUN 18
PY 2014
VL 53
IS 24
BP 10051
EP 10058
DI 10.1021/ie5004587
PG 8
WC Engineering, Chemical
SC Engineering
GA AJ5KG
UT WOS:000337720500012
ER
PT J
AU Warfield, KL
Goetzmann, JE
Biggins, JE
Kasda, MB
Unfer, RC
Vu, H
Aman, MJ
Olinger, GG
Walsh, PD
AF Warfield, Kelly L.
Goetzmann, Jason E.
Biggins, Julia E.
Kasda, Mary Beth
Unfer, Robert C.
Vu, Hong
Aman, M. Javad
Olinger, Gene Gerrard, Jr.
Walsh, Peter D.
TI Vaccinating captive chimpanzees to save wild chimpanzees
SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF
AMERICA
LA English
DT Article
DE conservation; wildlife disease; filovirus
ID EBOLA-VIRUS INFECTION; NONHUMAN-PRIMATES; PROTECTION; ANTIBODY;
GORILLAS; PARTICLES; DECLINE; CELLS; ASSAY
AB Infectious disease has only recently been recognized as a major threat to the survival of Endangered chimpanzees and Critically Endangered gorillas in the wild. One potentially powerful tool, vaccination, has not been deployed in fighting this disease threat, in good part because of fears about vaccine safety. Here we report on what is, to our knowledge, the first trial in which captive chimpanzees were used to test a vaccine intended for use on wild apes rather than humans. We tested a virus-like particle vaccine against Ebola virus, a leading source of death in wild gorillas and chimpanzees. The vaccine was safe and immunogenic. Captive trials of other vaccines and of methods for vaccine delivery hold great potential as weapons in the fight against wild ape extinction.
C1 [Warfield, Kelly L.; Unfer, Robert C.; Vu, Hong; Aman, M. Javad] Integrated BioTherapeut Inc, Gaithersburg, MD 20878 USA.
[Goetzmann, Jason E.] Univ Louisiana Lafayette, New Iberia Res Ctr, New Iberia, LA 70562 USA.
[Biggins, Julia E.; Kasda, Mary Beth; Olinger, Gene Gerrard, Jr.] US Army, Med Res Inst Infect Dis, Div Virol, Ft Detrick, MD 21702 USA.
[Walsh, Peter D.] Univ Cambridge, Dept Archael & Anthropol, Cambridge CB2 3QG, England.
RP Walsh, PD (reprint author), Univ Cambridge, Dept Archael & Anthropol, Cambridge CB2 3QG, England.
EM pdw36@cam.ac.uk
FU Paul G. Allen Family Foundation
FX We thank the New Iberia Research Center for a nocost extension to our
research, Kansas State University for administrative assistance, and The
Paul G. Allen Family Foundation for financial support.
NR 33
TC 12
Z9 14
U1 4
U2 75
PU NATL ACAD SCIENCES
PI WASHINGTON
PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA
SN 0027-8424
J9 P NATL ACAD SCI USA
JI Proc. Natl. Acad. Sci. U. S. A.
PD JUN 17
PY 2014
VL 111
IS 24
BP 8873
EP 8876
DI 10.1073/pnas.1316902111
PG 4
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA AI9XO
UT WOS:000337300100045
PM 24912183
ER
PT J
AU Titus, J
Filfili, C
Hilliard, JK
Ward, JA
Perera, AGU
AF Titus, Jitto
Filfili, Chadi
Hilliard, Julia K.
Ward, John A.
Perera, A. G. Unil
TI Early detection of cell activation events by means of attenuated total
reflection Fourier transform infrared spectroscopy
SO APPLIED PHYSICS LETTERS
LA English
DT Article
ID FTIR SPECTROSCOPY; TRANSCRIPTION; INFECTION
AB Activation of Jurkat T-cells in culture following treatment with anti-CD3 (Cluster of Differentiation 3) antibody is detectable by interrogating the treated T-cells using the Attenuated Total Reflection-Fourier Transform Infrared (ATR-FTIR) Spectroscopy technique. Cell activation was detected within 75 min after the cells encountered specific immunoglobulin molecules. Spectral markers noted following ligation of the CD3 receptor with anti CD3 antibody provides proof-of-concept that ATR-FTIR spectroscopy is a sensitive measure of molecular events subsequent to cells interacting with anti-CD3 Immunoglobulin G. The resultant ligation of the CD3 receptor results in the initiation of well defined, specific signaling pathways that parallel the measurable molecular events detected using ATR-FTIR. Paired t-test with post-hoc Bonferroni corrections for multiple comparisons has resulted in the identification of statistically significant spectral markers (p < 0.02) at 1367 and 1358 cm(-1). Together, these data demonstrate that early treatment-specific cellular events can be measured by ATR-FTIR and that this technique can be used to identify specific agents via the responses of the cell biosensor at different time points postexposure. (C) 2014 AIP Publishing LLC.
C1 [Titus, Jitto; Perera, A. G. Unil] GSU, Optoelect Lab, Dept Phys & Astron, Atlanta, GA 30303 USA.
[Filfili, Chadi; Hilliard, Julia K.] GSU, Dept Biol, Viral Immunol Ctr, Atlanta, GA 30303 USA.
[Ward, John A.] Brooke Army Med Ctr, Dept Clin Invest, San Antonio, TX 78234 USA.
RP Filfili, C (reprint author), GSU, Dept Biol, Viral Immunol Ctr, Atlanta, GA 30303 USA.
EM uperera@gsu.edu
FU Molecular Basis of Disease Area of Focus, Georgia State University,
Atlanta, GA; Georgia Research Alliance, AFOSR [55655-EL-DURIP]; DOD
[W81XWH-06-1-0795]
FX This work was supported in part by the Molecular Basis of Disease Area
of Focus, Georgia State University, Atlanta, GA 30303, Georgia Research
Alliance, AFOSR: 55655-EL-DURIP and DOD: W81XWH-06-1-0795.
NR 19
TC 1
Z9 1
U1 1
U2 12
PU AMER INST PHYSICS
PI MELVILLE
PA 1305 WALT WHITMAN RD, STE 300, MELVILLE, NY 11747-4501 USA
SN 0003-6951
EI 1077-3118
J9 APPL PHYS LETT
JI Appl. Phys. Lett.
PD JUN 16
PY 2014
VL 104
IS 24
AR 243705
DI 10.1063/1.4885081
PG 4
WC Physics, Applied
SC Physics
GA AJ7XQ
UT WOS:000337915000114
ER
PT J
AU Arun, P
Wilder, D
Edwards, E
Wang, Y
Gist, I
Long, JB
AF Arun, P.
Wilder, D.
Edwards, E.
Wang, Y.
Gist, I.
Long, J. B.
TI BLAST EXPOSURE PHOSPHORYLATES TAU PREFERENTIALLY AT SERINE396, WHICH CAN
TRIGGER ALZHEIMER'S-LIKE PATHOLOGY
SO JOURNAL OF NEUROTRAUMA
LA English
DT Meeting Abstract
CT 32nd Annual National Neurotrauma Symposium
CY JUN 29-JUL 02, 2014
CL San Francisco, CA
DE Alzheimer's disease; Alzheimer's-like pathology; blast exposure;
traumatic brain injury
C1 [Arun, P.; Wilder, D.; Edwards, E.; Wang, Y.; Gist, I.; Long, J. B.] Walter Reed Army Inst Res, Blast Induced Neurotrauma Branch, Ctr Mil Psychiat & Neurosci, Silver Spring, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0897-7151
EI 1557-9042
J9 J NEUROTRAUM
JI J. Neurotrauma
PD JUN 15
PY 2014
VL 31
IS 12
MA B5-05
BP A72
EP A72
PG 1
WC Critical Care Medicine; Clinical Neurology; Neurosciences
SC General & Internal Medicine; Neurosciences & Neurology
GA AK5DC
UT WOS:000338443600193
ER
PT J
AU Barazanji, K
Mayer, A
Kinsler, R
Wanner, I
Matchett, A
Rahmatalla, S
Wilder, D
Kwon, B
Cripton, P
Chambers, P
Reynolds, D
AF Barazanji, K.
Mayer, A.
Kinsler, R.
Wanner, I.
Matchett, A.
Rahmatalla, S.
Wilder, D.
Kwon, B.
Cripton, P.
Chambers, P.
Reynolds, D.
TI VIBRATION EXPOSURE LIMITS FOR NEUROTRAUMA PATIENTS DURING MEDICAL
TRANSPORT: OVERVIEW
SO JOURNAL OF NEUROTRAUMA
LA English
DT Meeting Abstract
CT 32nd Annual National Neurotrauma Symposium
CY JUN 29-JUL 02, 2014
CL San Francisco, CA
DE immobilization; medical transport; vibration
C1 [Barazanji, K.; Kinsler, R.] US Army Aeromed Res Lab, Ft Rucker, AL USA.
[Mayer, A.; Matchett, A.] Lovelace Resp Res Inst, Albuquerque, NM USA.
[Wanner, I.] Univ Calif Los Angeles, Los Angeles, CA USA.
[Rahmatalla, S.; Wilder, D.] Univ Iowa, Iowa City, IA USA.
[Kwon, B.; Cripton, P.] Univ British Columbia, Vancouver, WA USA.
[Chambers, P.] Mkt Assessment Inc, Sterling, VA USA.
[Reynolds, D.] Univ Nevada, Las Vegas, NV 89154 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0897-7151
EI 1557-9042
J9 J NEUROTRAUM
JI J. Neurotrauma
PD JUN 15
PY 2014
VL 31
IS 12
MA OC4-01
BP A13
EP A13
PG 1
WC Critical Care Medicine; Clinical Neurology; Neurosciences
SC General & Internal Medicine; Neurosciences & Neurology
GA AK5DC
UT WOS:000338443600031
ER
PT J
AU Boutte, AM
Mountney, A
Johnson, DW
Yarnell, A
Tortella, FC
Dave, JR
Shear, DA
Schmid, KE
AF Boutte, A. M.
Mountney, A.
Johnson, D. W.
Yarnell, A.
Tortella, F. C.
Dave, J. R.
Shear, D. A.
Schmid, K. E.
TI DELAYED CONSCIOUSNESS, SENSORY-MOTOR DEFICITS, AND GFAP LEVELS IN
REPEATED CONCUSSIVE IMPACT
SO JOURNAL OF NEUROTRAUMA
LA English
DT Meeting Abstract
CT 32nd Annual National Neurotrauma Symposium
CY JUN 29-JUL 02, 2014
CL San Francisco, CA
DE concussion; GFAP; mild TBI; serum
C1 [Boutte, A. M.; Mountney, A.; Johnson, D. W.; Yarnell, A.; Tortella, F. C.; Dave, J. R.; Shear, D. A.; Schmid, K. E.] Walter Reed Army Inst Res, Silver Spring, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0897-7151
EI 1557-9042
J9 J NEUROTRAUM
JI J. Neurotrauma
PD JUN 15
PY 2014
VL 31
IS 12
MA A4-02
BP A37
EP A37
PG 1
WC Critical Care Medicine; Clinical Neurology; Neurosciences
SC General & Internal Medicine; Neurosciences & Neurology
GA AK5DC
UT WOS:000338443600096
ER
PT J
AU Brophy, GM
Contaifer, D
Mohammed, BM
White, NJ
Newton, JC
Martin, EJ
Pusateri, AE
Ward, KR
Brophy, DF
AF Brophy, G. M.
Contaifer, D.
Mohammed, B. M.
White, N. J.
Newton, J. C.
Martin, E. J.
Pusateri, A. E.
Ward, K. R.
Brophy, D. F.
TI MULTIMODALITY MONITORING OF PLATELET FUNCTION IN TRAUMATIC BRAIN INJURY
PATIENTS WITH TRAUMA INDUCED COAGULOPATHY
SO JOURNAL OF NEUROTRAUMA
LA English
DT Meeting Abstract
CT 32nd Annual National Neurotrauma Symposium
CY JUN 29-JUL 02, 2014
CL San Francisco, CA
DE coagulation; platelet function
C1 [Brophy, G. M.; Contaifer, D.; Mohammed, B. M.; White, N. J.; Newton, J. C.; Martin, E. J.; Brophy, D. F.] Virginia Commonwealth Univ, Richmond, VA 23284 USA.
Puget Sound Blood Ctr, Seattle, WA 98104 USA.
[Pusateri, A. E.] US Army Med Res & Mat Command, Ft Detrick, MD USA.
[Ward, K. R.] Univ Michigan, Ann Arbor, MI 48109 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0897-7151
EI 1557-9042
J9 J NEUROTRAUM
JI J. Neurotrauma
PD JUN 15
PY 2014
VL 31
IS 12
MA A1-08
BP A19
EP A19
PG 1
WC Critical Care Medicine; Clinical Neurology; Neurosciences
SC General & Internal Medicine; Neurosciences & Neurology
GA AK5DC
UT WOS:000338443600047
ER
PT J
AU Cartagena, CM
Rammelkamp, Z
Phillips, KL
Tortella, FC
Schmid, KE
AF Cartagena, C. M.
Rammelkamp, Z.
Phillips, K. L.
Tortella, F. C.
Schmid, K. E.
TI PROLONGED INCREASES IN 22 KDA TAU FRAGMENT FOLLOWING PENETRATING TBI
SO JOURNAL OF NEUROTRAUMA
LA English
DT Meeting Abstract
CT 32nd Annual National Neurotrauma Symposium
CY JUN 29-JUL 02, 2014
CL San Francisco, CA
DE neurodegeneration; PBBI; severe TBI; tau
C1 [Cartagena, C. M.; Rammelkamp, Z.; Phillips, K. L.; Tortella, F. C.; Schmid, K. E.] Walter Reed Army Inst Res, Silver Spring, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0897-7151
EI 1557-9042
J9 J NEUROTRAUM
JI J. Neurotrauma
PD JUN 15
PY 2014
VL 31
IS 12
MA B5-06
BP A72
EP A72
PG 1
WC Critical Care Medicine; Clinical Neurology; Neurosciences
SC General & Internal Medicine; Neurosciences & Neurology
GA AK5DC
UT WOS:000338443600194
ER
PT J
AU Caudle, KL
Shear, DA
Pedersen, R
Sun, J
Flerlage, W
Faden, J
Mountney, A
Schmid, KE
Tortella, FC
Lu, XC
AF Caudle, K. L.
Shear, D. A.
Pedersen, R.
Sun, J.
Flerlage, W.
Faden, J.
Mountney, A.
Schmid, K. E.
Tortella, F. C.
Lu, X. C.
TI NEUROPROTECTIVE EFFECTS OF LEVETIRACETAM REQUIRES EXTENDED TREATMENT IN
A RAT MODEL OF PENETRATING BALLISTIC-LIKE BRAIN INJURY
SO JOURNAL OF NEUROTRAUMA
LA English
DT Meeting Abstract
CT 32nd Annual National Neurotrauma Symposium
CY JUN 29-JUL 02, 2014
CL San Francisco, CA
DE Keppra; levetiracetam; traumatic brain injury TBI
C1 [Caudle, K. L.; Shear, D. A.; Pedersen, R.; Sun, J.; Flerlage, W.; Faden, J.; Mountney, A.; Schmid, K. E.; Tortella, F. C.; Lu, X. C.] Walter Reed Army Inst Res, Silver Spring, MD USA.
NR 0
TC 1
Z9 1
U1 0
U2 0
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0897-7151
EI 1557-9042
J9 J NEUROTRAUM
JI J. Neurotrauma
PD JUN 15
PY 2014
VL 31
IS 12
MA C2-10
BP A80
EP A80
PG 1
WC Critical Care Medicine; Clinical Neurology; Neurosciences
SC General & Internal Medicine; Neurosciences & Neurology
GA AK5DC
UT WOS:000338443600215
ER
PT J
AU Caudle, KL
Pedersen, R
Sun, J
Flerlage, W
Faden, J
Mountney, A
Schmid, KE
Shear, DA
Tortella, FC
AF Caudle, K. L.
Pedersen, R.
Sun, J.
Flerlage, W.
Faden, J.
Mountney, A.
Schmid, K. E.
Shear, D. A.
Tortella, F. C.
TI EVALUATION OF LEVETIRACETAM IN THE WRAIR PBBI MODEL: STUDIES FROM THE
OPERATION BRAIN TRAUMA THERAPY (OBTT) CONSORTIUM
SO JOURNAL OF NEUROTRAUMA
LA English
DT Meeting Abstract
CT 32nd Annual National Neurotrauma Symposium
CY JUN 29-JUL 02, 2014
CL San Francisco, CA
DE cognitive; Keppra; levetiracetam; motor; operation brain trauma therapy
OBTT; traumatic brain injury TBI
C1 [Caudle, K. L.; Pedersen, R.; Sun, J.; Flerlage, W.; Faden, J.; Mountney, A.; Schmid, K. E.; Shear, D. A.; Tortella, F. C.] Walter Reed Army Inst Res, Silver Spring, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0897-7151
EI 1557-9042
J9 J NEUROTRAUM
JI J. Neurotrauma
PD JUN 15
PY 2014
VL 31
IS 12
MA C2-09
BP A79
EP A79
PG 1
WC Critical Care Medicine; Clinical Neurology; Neurosciences
SC General & Internal Medicine; Neurosciences & Neurology
GA AK5DC
UT WOS:000338443600214
ER
PT J
AU Chen, ZY
Lu, XM
Liao, ZL
Tortella, F
Shear, D
AF Chen, Z. Y.
Lu, X. M.
Liao, Z. L.
Tortella, F.
Shear, D.
TI APPLICATION OF AN ACTIVE AVOIDANCE TASK IN DETECTING COGNITIVE DEFICITS
FOLLOWING PENETRATING BALLISTIC-LIKE BRAIN INJURY
SO JOURNAL OF NEUROTRAUMA
LA English
DT Meeting Abstract
CT 32nd Annual National Neurotrauma Symposium
CY JUN 29-JUL 02, 2014
CL San Francisco, CA
DE active avoidance task; learning and memory; penetrating ballistic-like
brain injury
C1 [Chen, Z. Y.; Lu, X. M.; Liao, Z. L.; Tortella, F.; Shear, D.] Walter Reed Army Inst Res, Silver Spring, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0897-7151
EI 1557-9042
J9 J NEUROTRAUM
JI J. Neurotrauma
PD JUN 15
PY 2014
VL 31
IS 12
MA A5-03
BP A43
EP A43
PG 1
WC Critical Care Medicine; Clinical Neurology; Neurosciences
SC General & Internal Medicine; Neurosciences & Neurology
GA AK5DC
UT WOS:000338443600114
ER
PT J
AU DeGraba, TJ
Popescu, M
Popescu, A
Balbir, A
Bleiberg, J
Riedy, G
Balkin, T
Merrifield, W
AF DeGraba, T. J.
Popescu, M.
Popescu, A.
Balbir, A.
Bleiberg, J.
Riedy, G.
Balkin, T.
Merrifield, W.
TI RESTING-STATE BRAIN ACTIVITY IN MILD TBI PATIENTS WITH HIGH VERSUS LOW
POST-TRAUMATIC STRESS DISORDER SYMPTOM SEVERITY
SO JOURNAL OF NEUROTRAUMA
LA English
DT Meeting Abstract
CT 32nd Annual National Neurotrauma Symposium
CY JUN 29-JUL 02, 2014
CL San Francisco, CA
DE magnetoencephalography; MRI; mTBI; PTSD
C1 [DeGraba, T. J.; Popescu, M.; Popescu, A.; Balbir, A.; Bleiberg, J.; Riedy, G.; Merrifield, W.] Natl Intrepid Ctr Excellence, Bethesda, MD USA.
[Balkin, T.] Walter Reed Army Inst Res, Silver Spring, MD USA.
NR 0
TC 0
Z9 0
U1 1
U2 14
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0897-7151
EI 1557-9042
J9 J NEUROTRAUM
JI J. Neurotrauma
PD JUN 15
PY 2014
VL 31
IS 12
MA A2-10
BP A27
EP A28
PG 2
WC Critical Care Medicine; Clinical Neurology; Neurosciences
SC General & Internal Medicine; Neurosciences & Neurology
GA AK5DC
UT WOS:000338443600071
ER
PT J
AU Deng-Bryant, Y
Leung, LY
Flerlage, WJ
Winter, M
Yang, W
Tortella, FC
Shear, DA
AF Deng-Bryant, Y.
Leung, L. Y.
Flerlage, W. J.
Winter, M.
Yang, W.
Tortella, F. C.
Shear, D. A.
TI COMPREHENSIVE EVALUATION OF CHRONIC SPATIAL LEARNING AND WORKING MEMORY
DEFICITS FOLLOWING CLOSED-HEAD CONCUSSIVE INJURY IN RATS
SO JOURNAL OF NEUROTRAUMA
LA English
DT Meeting Abstract
CT 32nd Annual National Neurotrauma Symposium
CY JUN 29-JUL 02, 2014
CL San Francisco, CA
DE chronic effects; concussion; spatial learning; working memory
C1 [Deng-Bryant, Y.; Leung, L. Y.; Flerlage, W. J.; Winter, M.; Yang, W.; Tortella, F. C.; Shear, D. A.] Walter Reed Army Inst Res, Silver Spring, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0897-7151
EI 1557-9042
J9 J NEUROTRAUM
JI J. Neurotrauma
PD JUN 15
PY 2014
VL 31
IS 12
MA D2-15
BP A118
EP A118
PG 1
WC Critical Care Medicine; Clinical Neurology; Neurosciences
SC General & Internal Medicine; Neurosciences & Neurology
GA AK5DC
UT WOS:000338443600321
ER
PT J
AU Deng-Bryant, Y
Leung, LY
Tortella, FC
Shear, DA
AF Deng-Bryant, Y.
Leung, L. Y.
Tortella, F. C.
Shear, D. A.
TI PENETRATING BALLISTIC-LIKE BRAIN INJURY PROMOTES TIME-DEPENDENT CELL
PROLIFERATION IN ADULT RAT HIPPOCAMPUS
SO JOURNAL OF NEUROTRAUMA
LA English
DT Meeting Abstract
CT 32nd Annual National Neurotrauma Symposium
CY JUN 29-JUL 02, 2014
CL San Francisco, CA
DE cell proliferation; gliogenesis; hippocampus
C1 [Deng-Bryant, Y.; Leung, L. Y.; Tortella, F. C.; Shear, D. A.] Walter Reed Army Inst Res, Silver Spring, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0897-7151
EI 1557-9042
J9 J NEUROTRAUM
JI J. Neurotrauma
PD JUN 15
PY 2014
VL 31
IS 12
MA D2-14
BP A118
EP A118
PG 1
WC Critical Care Medicine; Clinical Neurology; Neurosciences
SC General & Internal Medicine; Neurosciences & Neurology
GA AK5DC
UT WOS:000338443600320
ER
PT J
AU Deng-Bryant, Y
Caudle, K
Leung, LY
Winter, M
Yang, X
Cartagena, C
Boutte, A
Schmid, K
Shear, DA
Tortella, FC
AF Deng-Bryant, Y.
Caudle, K.
Leung, L. Y.
Winter, M.
Yang, X.
Cartagena, C.
Boutte, A.
Schmid, K.
Shear, D. A.
Tortella, F. C.
TI EFFECT OF NNZ-2591 TREATMENT ON AXONAL AND SYNAPTIC PLASTICITY FOLLOWING
PENETRATING BALLISTIC-LIKE INJURY IN RATS
SO JOURNAL OF NEUROTRAUMA
LA English
DT Meeting Abstract
CT 32nd Annual National Neurotrauma Symposium
CY JUN 29-JUL 02, 2014
CL San Francisco, CA
DE axonal sprouting; diketopiperazine; synaptogenesis
C1 [Deng-Bryant, Y.; Caudle, K.; Leung, L. Y.; Winter, M.; Yang, X.; Cartagena, C.; Boutte, A.; Schmid, K.; Shear, D. A.; Tortella, F. C.] Walter Reed Army Inst Res, Silver Spring, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0897-7151
EI 1557-9042
J9 J NEUROTRAUM
JI J. Neurotrauma
PD JUN 15
PY 2014
VL 31
IS 12
MA D1-08
BP A103
EP A103
PG 1
WC Critical Care Medicine; Clinical Neurology; Neurosciences
SC General & Internal Medicine; Neurosciences & Neurology
GA AK5DC
UT WOS:000338443600280
ER
PT J
AU Deng-Bryant, Y
Leung, LY
Readnower, R
Tortella, FC
Shear, DA
AF Deng-Bryant, Y.
Leung, L. Y.
Readnower, R.
Tortella, F. C.
Shear, D. A.
TI REGION-SPECIFIC IMPAIRMENT OF CEREBRAL MITOCHONDRIAL BIOENERGETICS
FOLLOWING PENETRATING BALLISTIC-LIKE BRAIN INJURY IN RATS
SO JOURNAL OF NEUROTRAUMA
LA English
DT Meeting Abstract
CT 32nd Annual National Neurotrauma Symposium
CY JUN 29-JUL 02, 2014
CL San Francisco, CA
DE mitochondrial bioenergetics; penetrating ballistic-like brain injury;
respiration
C1 [Deng-Bryant, Y.; Leung, L. Y.; Readnower, R.; Tortella, F. C.; Shear, D. A.] Walter Reed Army Inst Res, Silver Spring, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0897-7151
EI 1557-9042
J9 J NEUROTRAUM
JI J. Neurotrauma
PD JUN 15
PY 2014
VL 31
IS 12
MA C3-15
BP A94
EP A94
PG 1
WC Critical Care Medicine; Clinical Neurology; Neurosciences
SC General & Internal Medicine; Neurosciences & Neurology
GA AK5DC
UT WOS:000338443600255
ER
PT J
AU Deng-Bryant, Y
Leung, LY
Readnower, R
Yang, W
Shear, DA
Tortella, FC
AF Deng-Bryant, Y.
Leung, L. Y.
Readnower, R.
Yang, W.
Shear, D. A.
Tortella, F. C.
TI GLOBAL METABOLOMICS PROFILING REVEALS METABOLIC DYSREGULATION, OXIDATIVE
STRESS AND NEUROTRANSMISSION ALTERATION AFTER CONCUSSION
SO JOURNAL OF NEUROTRAUMA
LA English
DT Meeting Abstract
CT 32nd Annual National Neurotrauma Symposium
CY JUN 29-JUL 02, 2014
CL San Francisco, CA
DE concussion; glucose metabolism; metabolomics; oxidative stress
C1 [Deng-Bryant, Y.; Leung, L. Y.; Readnower, R.; Yang, W.; Shear, D. A.; Tortella, F. C.] Walter Reed Army Inst Res, Silver Spring, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0897-7151
EI 1557-9042
J9 J NEUROTRAUM
JI J. Neurotrauma
PD JUN 15
PY 2014
VL 31
IS 12
MA OC1-02
BP A10
EP A10
PG 1
WC Critical Care Medicine; Clinical Neurology; Neurosciences
SC General & Internal Medicine; Neurosciences & Neurology
GA AK5DC
UT WOS:000338443600023
ER
PT J
AU Johnson, D
Casandra, CM
Boutte, AM
Tortella, FC
Dave, JR
Schmid, KE
AF Johnson, D.
Casandra, C. M.
Boutte, A. M.
Tortella, F. C.
Dave, J. R.
Schmid, K. E.
TI MICRORNA DYSREGULATION OCCURS AT ACUTE TIME POINTS AFTER PENETRATING
BALLISTIC-LIKE BRAIN INJURY
SO JOURNAL OF NEUROTRAUMA
LA English
DT Meeting Abstract
CT 32nd Annual National Neurotrauma Symposium
CY JUN 29-JUL 02, 2014
CL San Francisco, CA
DE severe TBI
C1 [Johnson, D.; Casandra, C. M.; Boutte, A. M.; Tortella, F. C.; Dave, J. R.; Schmid, K. E.] Walter Reed Army Inst Res, Silver Spring, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0897-7151
EI 1557-9042
J9 J NEUROTRAUM
JI J. Neurotrauma
PD JUN 15
PY 2014
VL 31
IS 12
MA C3-06
BP A91
EP A91
PG 1
WC Critical Care Medicine; Clinical Neurology; Neurosciences
SC General & Internal Medicine; Neurosciences & Neurology
GA AK5DC
UT WOS:000338443600246
ER
PT J
AU Kelley, AM
Ranes, B
Estrada, A
Grandizio, CM
AF Kelley, A. M.
Ranes, B.
Estrada, A.
Grandizio, C. M.
TI EVALUATION OF THE MILITARY FUNCTIONAL ASSESSMENT PROGRAM: ASSESSMENT OF
THE CONSTRUCT VALIDITY USING ARCHIVED CLINICAL DATA
SO JOURNAL OF NEUROTRAUMA
LA English
DT Meeting Abstract
CT 32nd Annual National Neurotrauma Symposium
CY JUN 29-JUL 02, 2014
CL San Francisco, CA
DE fitness-for-duty; military; return-to-duty
C1 [Kelley, A. M.; Estrada, A.; Grandizio, C. M.] US Army Aeromed Res Lab, Ft Rucker, AL USA.
[Ranes, B.] Oak Ridge Inst Sci & Educ, Belcamp, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0897-7151
EI 1557-9042
J9 J NEUROTRAUM
JI J. Neurotrauma
PD JUN 15
PY 2014
VL 31
IS 12
MA B1-01
BP A44
EP A45
PG 2
WC Critical Care Medicine; Clinical Neurology; Neurosciences
SC General & Internal Medicine; Neurosciences & Neurology
GA AK5DC
UT WOS:000338443600118
ER
PT J
AU Kochanek, PM
Bramlett, H
Shear, D
Dixon, CE
Dietrich, WD
Poloyac, S
Empey, PE
Schmid, K
Mondello, S
Wang, KK
Hayes, R
Tortella, F
AF Kochanek, P. M.
Bramlett, H.
Shear, D.
Dixon, C. E.
Dietrich, W. D.
Poloyac, S.
Empey, P. E.
Schmid, K.
Mondello, S.
Wang, K. K.
Hayes, R.
Tortella, F.
TI MULTICENTER COMPARISON OF FIVE THERAPIES REVEALS THERAPEUTIC POTENTIAL
FOR LEVETIRACETAM: OPERATION BRAIN TRAUMA THERAPY
SO JOURNAL OF NEUROTRAUMA
LA English
DT Meeting Abstract
CT 32nd Annual National Neurotrauma Symposium
CY JUN 29-JUL 02, 2014
CL San Francisco, CA
DE biomarker; consortium; pre-clinical; therapy
C1 [Kochanek, P. M.; Dixon, C. E.; Poloyac, S.; Empey, P. E.] Safar Ctr, Pittsburgh, PA USA.
[Kochanek, P. M.; Dixon, C. E.; Poloyac, S.; Empey, P. E.] Univ Pittsburgh, Pittsburgh, PA USA.
[Bramlett, H.; Dietrich, W. D.] Univ Miami, Miami, FL USA.
[Shear, D.; Schmid, K.] Walter Reed Army Inst Res, Silver Spring, MD USA.
[Wang, K. K.] Univ Florida, Gainesville, FL USA.
[Mondello, S.] Univ Messina, Messina, Italy.
[Hayes, R.] Banyan Biomarkers, Alachua, FL USA.
RI Kochanek, Patrick/D-2371-2015
OI Kochanek, Patrick/0000-0002-2627-913X
NR 0
TC 0
Z9 0
U1 0
U2 1
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0897-7151
EI 1557-9042
J9 J NEUROTRAUM
JI J. Neurotrauma
PD JUN 15
PY 2014
VL 31
IS 12
MA D1-14
BP A105
EP A105
PG 1
WC Critical Care Medicine; Clinical Neurology; Neurosciences
SC General & Internal Medicine; Neurosciences & Neurology
GA AK5DC
UT WOS:000338443600286
ER
PT J
AU Lawson, BD
Kass, SJ
Dhillon, K
Cho, TH
Rupert, AH
AF Lawson, B. D.
Kass, S. J.
Dhillon, K.
Cho, T. H.
Rupert, A. H.
TI IDENTIFICATION OF MILITARY OCCUPATIONS MOST LIKELY TO SUFFER MILD
TRAUMATIC BRAIN INJURY (MTBI) AND RELATED SENSORY INJURIES
SO JOURNAL OF NEUROTRAUMA
LA English
DT Meeting Abstract
CT 32nd Annual National Neurotrauma Symposium
CY JUN 29-JUL 02, 2014
CL San Francisco, CA
DE blast injury; fitness-for-duty; mild traumatic brain injury; military
brain injury; return-to-duty
C1 [Lawson, B. D.; Cho, T. H.; Rupert, A. H.] US Army Aeromed Res Lab, Ft Rucker, AL USA.
[Kass, S. J.] Univ W Florida, Pensacola, FL 32514 USA.
[Dhillon, K.] 22nd Special Tact Squadron, McChord AFB, WA USA.
NR 0
TC 0
Z9 0
U1 0
U2 2
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0897-7151
EI 1557-9042
J9 J NEUROTRAUM
JI J. Neurotrauma
PD JUN 15
PY 2014
VL 31
IS 12
MA B1-11
BP A48
EP A48
PG 1
WC Critical Care Medicine; Clinical Neurology; Neurosciences
SC General & Internal Medicine; Neurosciences & Neurology
GA AK5DC
UT WOS:000338443600128
ER
PT J
AU Lee, SW
Gajavelli, S
Vaccari, JPD
Brand, F
Spurlock, M
Shear, D
Tortella, FC
Bullock, MR
Keane, RW
AF Lee, S. W.
Gajavelli, S.
Vaccari, de Rivero J. P.
Brand, F., III
Spurlock, M.
Shear, D.
Tortella, F. C.
Bullock, M. R.
Keane, R. W.
TI THE INFLAMMASOME IS ACTIVATED IN THE CORTEX OF RATS FOLLOWING
PENETRATING BALLISTIC BRAIN INJURY
SO JOURNAL OF NEUROTRAUMA
LA English
DT Meeting Abstract
CT 32nd Annual National Neurotrauma Symposium
CY JUN 29-JUL 02, 2014
CL San Francisco, CA
DE ballistic-like; brain injury; penetrating; traumatic
C1 [Lee, S. W.; Gajavelli, S.; Vaccari, de Rivero J. P.; Brand, F., III; Spurlock, M.; Bullock, M. R.; Keane, R. W.] Univ Miami, Miller Sch Med, Dept Neurosurg, Miami Project Cure Paralysis, Miami, FL 33136 USA.
[Shear, D.; Tortella, F. C.] Walter Reed Army Inst Res, Silver Spring, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0897-7151
EI 1557-9042
J9 J NEUROTRAUM
JI J. Neurotrauma
PD JUN 15
PY 2014
VL 31
IS 12
MA C3-16
BP A94
EP A95
PG 2
WC Critical Care Medicine; Clinical Neurology; Neurosciences
SC General & Internal Medicine; Neurosciences & Neurology
GA AK5DC
UT WOS:000338443600256
ER
PT J
AU Leung, LY
Deng-Bryant, Y
Flerlage, WJ
Winter, M
Bustos, F
Shear, DA
Tortella, FC
AF Leung, L. Y.
Deng-Bryant, Y.
Flerlage, W. J.
Winter, M.
Bustos, F.
Shear, D. A.
Tortella, F. C.
TI COMBINED HYPOXEMIA & HEMORRHAGIC SHOCK WORSEN MOTOR BUT NOT COGNITIVE
FUNCTION AFTER PENETRATING BALLISTIC-LIKE BRAIN INJURY
SO JOURNAL OF NEUROTRAUMA
LA English
DT Meeting Abstract
CT 32nd Annual National Neurotrauma Symposium
CY JUN 29-JUL 02, 2014
CL San Francisco, CA
DE cognitive; hemorrhagic shock; hypoxemia; motor; neurobehavior;
penetrating ballistic-like brain injury
C1 [Leung, L. Y.; Deng-Bryant, Y.; Flerlage, W. J.; Winter, M.; Bustos, F.; Shear, D. A.; Tortella, F. C.] Walter Reed Army Inst Res, Silver Spring, MD USA.
NR 0
TC 1
Z9 1
U1 0
U2 0
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0897-7151
EI 1557-9042
J9 J NEUROTRAUM
JI J. Neurotrauma
PD JUN 15
PY 2014
VL 31
IS 12
MA D2-13
BP A117
EP A117
PG 1
WC Critical Care Medicine; Clinical Neurology; Neurosciences
SC General & Internal Medicine; Neurosciences & Neurology
GA AK5DC
UT WOS:000338443600319
ER
PT J
AU Leung, LY
Deng-Bryant, Y
Yang, W
Winter, M
Tortella, FC
Shear, DA
AF Leung, L. Y.
Deng-Bryant, Y.
Yang, W.
Winter, M.
Tortella, F. C.
Shear, D. A.
TI REGIONAL AND TEMPORAL HISTOPATHOLOGICAL CHANGES FOLLOWING MILD
CONCUSSIVE BRAIN INJURY
SO JOURNAL OF NEUROTRAUMA
LA English
DT Meeting Abstract
CT 32nd Annual National Neurotrauma Symposium
CY JUN 29-JUL 02, 2014
CL San Francisco, CA
DE axonal injury; concussion; glial activation; histopathology
C1 [Leung, L. Y.; Deng-Bryant, Y.; Yang, W.; Winter, M.; Tortella, F. C.; Shear, D. A.] Walter Reed Army Inst Res, Silver Spring, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0897-7151
EI 1557-9042
J9 J NEUROTRAUM
JI J. Neurotrauma
PD JUN 15
PY 2014
VL 31
IS 12
MA C3-14
BP A94
EP A94
PG 1
WC Critical Care Medicine; Clinical Neurology; Neurosciences
SC General & Internal Medicine; Neurosciences & Neurology
GA AK5DC
UT WOS:000338443600254
ER
PT J
AU Lu, XM
Tallarida, R
Mountney, A
Cao, Y
Liao, Z
Schmid, KE
Shear, DA
Tortella, FC
AF Lu, X. M.
Tallarida, R.
Mountney, A.
Cao, Y.
Liao, Z.
Schmid, K. E.
Shear, D. A.
Tortella, F. C.
TI A COMBINATION THERAPY OF PHENYTOIN AND ETHOSUXIMIDE IMPROVED THERAPEUTIC
BENEFITS AGAINST POST-TRAUMATIC NONCONVULSIVE SEIZURES
SO JOURNAL OF NEUROTRAUMA
LA English
DT Meeting Abstract
CT 32nd Annual National Neurotrauma Symposium
CY JUN 29-JUL 02, 2014
CL San Francisco, CA
DE anti-seizure combination therapy; ethosuximide; penetrating brain
injury; phenytoin
C1 [Lu, X. M.; Mountney, A.; Cao, Y.; Liao, Z.; Schmid, K. E.; Shear, D. A.; Tortella, F. C.] Walter Reed Army Inst Res, Silver Spring, MD USA.
[Tallarida, R.] Temple Univ, Philadelphia, PA 19122 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0897-7151
EI 1557-9042
J9 J NEUROTRAUM
JI J. Neurotrauma
PD JUN 15
PY 2014
VL 31
IS 12
MA C2-04
BP A77
EP A78
PG 2
WC Critical Care Medicine; Clinical Neurology; Neurosciences
SC General & Internal Medicine; Neurosciences & Neurology
GA AK5DC
UT WOS:000338443600209
ER
PT J
AU Mondello, S
Shear, DA
Bramlett, HM
Dixon, CE
Schmid, K
Dietrich, WD
Wang, KK
Hayes, RL
Tortella, FC
Kochanek, PM
AF Mondello, S.
Shear, D. A.
Bramlett, H. M.
Dixon, C. E.
Schmid, K.
Dietrich, W. D.
Wang, K. K.
Hayes, R. L.
Tortella, F. C.
Kochanek, P. M.
TI COMPARISON OF TBI MODELS USING BRAIN DAMAGE MARKERS, AND HISTOLOGICAL
AND BEHAVIORAL OUTCOMES IN OPERATION BRAIN TRAUMA THERAPY
SO JOURNAL OF NEUROTRAUMA
LA English
DT Meeting Abstract
CT 32nd Annual National Neurotrauma Symposium
CY JUN 29-JUL 02, 2014
CL San Francisco, CA
DE animal model; OBTT; traumatic brain injury
C1 [Mondello, S.] Univ Messina, Messina, Italy.
[Shear, D. A.; Schmid, K.; Tortella, F. C.] Walter Reed Army Inst Res, Silver Spring, MD USA.
[Bramlett, H. M.; Dietrich, W. D.] Univ Miami Miller Sch Med, Miami, FL USA.
[Dixon, C. E.; Kochanek, P. M.] Univ Pittsburgh, Pittsburgh, PA USA.
[Wang, K. K.] Univ Florida, Gainesville, FL USA.
[Hayes, R. L.] Banyan Biomarkers, Alachua, FL USA.
RI Kochanek, Patrick/D-2371-2015
OI Kochanek, Patrick/0000-0002-2627-913X
NR 0
TC 0
Z9 0
U1 0
U2 1
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0897-7151
EI 1557-9042
J9 J NEUROTRAUM
JI J. Neurotrauma
PD JUN 15
PY 2014
VL 31
IS 12
MA D2-21
BP A120
EP A120
PG 1
WC Critical Care Medicine; Clinical Neurology; Neurosciences
SC General & Internal Medicine; Neurosciences & Neurology
GA AK5DC
UT WOS:000338443600327
ER
PT J
AU Mountney, A
Rho, C
Yang, W
Flerlage, J
Yarnell, A
Cartagena, C
Schmid, K
Bliese, P
Tortella, FC
Shear, DA
AF Mountney, A.
Rho, C.
Yang, W.
Flerlage, J.
Yarnell, A.
Cartagena, C.
Schmid, K.
Bliese, P.
Tortella, F. C.
Shear, D. A.
TI LONGITUDINAL PROFILE OF SENSORIMOTOR DEFICITS FOLLOWING SINGLE AND
REPEATED PROJECTILE CONCUSSIVE INJURY (PCI)
SO JOURNAL OF NEUROTRAUMA
LA English
DT Meeting Abstract
CT 32nd Annual National Neurotrauma Symposium
CY JUN 29-JUL 02, 2014
CL San Francisco, CA
DE gait analysis; mild TBI; motor/balance; neuropathology
C1 [Mountney, A.; Rho, C.; Yang, W.; Flerlage, J.; Yarnell, A.; Cartagena, C.; Schmid, K.; Bliese, P.; Tortella, F. C.; Shear, D. A.] Walter Reed Army Inst Res, Silver Spring, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0897-7151
EI 1557-9042
J9 J NEUROTRAUM
JI J. Neurotrauma
PD JUN 15
PY 2014
VL 31
IS 12
MA D2-17
BP A119
EP A119
PG 1
WC Critical Care Medicine; Clinical Neurology; Neurosciences
SC General & Internal Medicine; Neurosciences & Neurology
GA AK5DC
UT WOS:000338443600323
ER
PT J
AU Mountney, A
Readnower, R
Cunningham, T
Pedersen, R
Sun, J
Flerlage, J
Caudle, K
Schmid, K
Tortella, FC
Shear, DA
AF Mountney, A.
Readnower, R.
Cunningham, T.
Pedersen, R.
Sun, J.
Flerlage, J.
Caudle, K.
Schmid, K.
Tortella, F. C.
Shear, D. A.
TI EVALUATION OF SIMVASTATIN IN THE WRAIR PBBI MODEL: STUDIES FROM THE
OPERATION BRAIN TRAUMA THERAPY (OBTT) CONSORTIUM
SO JOURNAL OF NEUROTRAUMA
LA English
DT Meeting Abstract
CT 32nd Annual National Neurotrauma Symposium
CY JUN 29-JUL 02, 2014
CL San Francisco, CA
DE neuroprotection; OBTT; PBBI; simvastatin; TBI
C1 [Mountney, A.; Readnower, R.; Cunningham, T.; Pedersen, R.; Sun, J.; Flerlage, J.; Caudle, K.; Schmid, K.; Tortella, F. C.; Shear, D. A.] Walter Reed Army Inst Res, Silver Spring, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0897-7151
EI 1557-9042
J9 J NEUROTRAUM
JI J. Neurotrauma
PD JUN 15
PY 2014
VL 31
IS 12
MA C2-14
BP A81
EP A81
PG 1
WC Critical Care Medicine; Clinical Neurology; Neurosciences
SC General & Internal Medicine; Neurosciences & Neurology
GA AK5DC
UT WOS:000338443600219
ER
PT J
AU Sharrow, KM
DeMar, JC
Hill, MI
Edwards, AA
Long, JB
Oliver, TG
AF Sharrow, K. M.
DeMar, J. C.
Hill, M., I
Edwards, A. A.
Long, J. B.
Oliver, T. G.
TI CHARACTERIZATION OF A BLAST-INDUCED BRAIN AND EYE INJURY MODEL IN RATS
SO JOURNAL OF NEUROTRAUMA
LA English
DT Meeting Abstract
CT 32nd Annual National Neurotrauma Symposium
CY JUN 29-JUL 02, 2014
CL San Francisco, CA
DE blast injury; eye injury; TBI; vision processing centers
C1 [Sharrow, K. M.; Oliver, T. G.] Walter Reed Army Inst Res, Dept Clin Pharmacol & Translat Med, Silver Spring, MD USA.
[DeMar, J. C.; Hill, M., I; Edwards, A. A.; Long, J. B.] Walter Reed Army Inst Res, Blast Induced Neurotrauma Branch, Silver Spring, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0897-7151
EI 1557-9042
J9 J NEUROTRAUM
JI J. Neurotrauma
PD JUN 15
PY 2014
VL 31
IS 12
MA D2-11
BP A116
EP A117
PG 2
WC Critical Care Medicine; Clinical Neurology; Neurosciences
SC General & Internal Medicine; Neurosciences & Neurology
GA AK5DC
UT WOS:000338443600317
ER
PT J
AU Shear, DA
Caudle, KL
Mountney, A
Deng-Bryant, Y
Pedersen, R
Sun, J
Schmid, K
Lu, M
Tallarida, RJ
Tortella, FC
AF Shear, D. A.
Caudle, K. L.
Mountney, A.
Deng-Bryant, Y.
Pedersen, R.
Sun, J.
Schmid, K.
Lu, M.
Tallarida, R. J.
Tortella, F. C.
TI EVALUATION OF COMBINED ADMINISTRATION OF DEXTROMETHORPHAN AND
SIMVASTATIN IN AN EXPERIMENTAL MODEL OF TRAUMATIC BRAIN INJURY
SO JOURNAL OF NEUROTRAUMA
LA English
DT Meeting Abstract
CT 32nd Annual National Neurotrauma Symposium
CY JUN 29-JUL 02, 2014
CL San Francisco, CA
DE cognitive; combination therapy; motor; PBBI; TBI
C1 [Shear, D. A.; Caudle, K. L.; Mountney, A.; Deng-Bryant, Y.; Pedersen, R.; Sun, J.; Schmid, K.; Lu, M.; Tortella, F. C.] Walter Reed Army Inst Res, Silver Spring, MD USA.
[Tallarida, R. J.] Temple Univ, Sch Med, Philadelphia, PA 19122 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0897-7151
EI 1557-9042
J9 J NEUROTRAUM
JI J. Neurotrauma
PD JUN 15
PY 2014
VL 31
IS 12
MA D1-09
BP A103
EP A104
PG 2
WC Critical Care Medicine; Clinical Neurology; Neurosciences
SC General & Internal Medicine; Neurosciences & Neurology
GA AK5DC
UT WOS:000338443600281
ER
PT J
AU Spurlock, MS
Hosein, K
Bullock, MR
Gajavelli, S
Yokobori, S
O'Connell-Blaya, M
Leung, LY
Tortella, FC
AF Spurlock, M. S.
Hosein, K.
Bullock, M. R.
Gajavelli, S.
Yokobori, S.
O'Connell-Blaya, M.
Leung, L. Y.
Tortella, F. C.
TI MULTINEUROTROPHIN EXPRESSING FETAL CELL TRANSPLANT IN PENETRATING
BALLISTIC BRAIN INJURY (PBBI)
SO JOURNAL OF NEUROTRAUMA
LA English
DT Meeting Abstract
CT 32nd Annual National Neurotrauma Symposium
CY JUN 29-JUL 02, 2014
CL San Francisco, CA
DE chronic TBI; stem cell
C1 [Spurlock, M. S.; Hosein, K.; Bullock, M. R.; Gajavelli, S.; Yokobori, S.; O'Connell-Blaya, M.] Univ Miami, Miller Sch Med, Miami, FL 33136 USA.
[Leung, L. Y.; Tortella, F. C.] Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci, Silver Spring, MD USA.
[Yokobori, S.] Nippon Med Sch, Dept Emergency & Crit Care Med, Tokyo 113, Japan.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0897-7151
EI 1557-9042
J9 J NEUROTRAUM
JI J. Neurotrauma
PD JUN 15
PY 2014
VL 31
IS 12
MA D1-27
BP A110
EP A110
PG 1
WC Critical Care Medicine; Clinical Neurology; Neurosciences
SC General & Internal Medicine; Neurosciences & Neurology
GA AK5DC
UT WOS:000338443600299
ER
PT J
AU Wang, Y
Wei, Y
Tong, LC
Arun, P
Edwares, AA
Oguntagyo, SA
Gist, ID
Long, JB
AF Wang, Y.
Wei, Y.
Tong, L. C.
Arun, P.
Edwares, A. A.
Oguntagyo, S. A.
Gist, I. D.
Long, J. B.
TI CHARACTERIZATION OF BLAST-INDUCED VESTIBULAR INJURY IN RATS
SO JOURNAL OF NEUROTRAUMA
LA English
DT Meeting Abstract
CT 32nd Annual National Neurotrauma Symposium
CY JUN 29-JUL 02, 2014
CL San Francisco, CA
DE blast TBI; inflammation; motor coordination; pathology; vestibular
system
C1 [Wang, Y.; Wei, Y.; Tong, L. C.; Arun, P.; Edwares, A. A.; Oguntagyo, S. A.; Gist, I. D.; Long, J. B.] Walter Reed Army Inst Res, Silver Spring, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0897-7151
EI 1557-9042
J9 J NEUROTRAUM
JI J. Neurotrauma
PD JUN 15
PY 2014
VL 31
IS 12
MA D2-02
BP A113
EP A113
PG 1
WC Critical Care Medicine; Clinical Neurology; Neurosciences
SC General & Internal Medicine; Neurosciences & Neurology
GA AK5DC
UT WOS:000338443600309
ER
PT J
AU Wei, G
Yang, XY
Shear, DA
Tortella, FC
AF Wei, G.
Yang, X. Y.
Shear, D. A.
Tortella, F. C.
TI THERAPEUTIC WINDOW FOR SELECTIVE BRAIN COOLING FOLLOWING PENETRATING
BALLISTIC-LIKE BRAIN INJURY IN RATS
SO JOURNAL OF NEUROTRAUMA
LA English
DT Meeting Abstract
CT 32nd Annual National Neurotrauma Symposium
CY JUN 29-JUL 02, 2014
CL San Francisco, CA
DE function; hypothermia; penetrating brain injury; therapeutic window
C1 [Wei, G.; Yang, X. Y.; Shear, D. A.; Tortella, F. C.] Walter Reed Army Inst Res, Silver Spring, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0897-7151
EI 1557-9042
J9 J NEUROTRAUM
JI J. Neurotrauma
PD JUN 15
PY 2014
VL 31
IS 12
MA C2-05
BP A78
EP A78
PG 1
WC Critical Care Medicine; Clinical Neurology; Neurosciences
SC General & Internal Medicine; Neurosciences & Neurology
GA AK5DC
UT WOS:000338443600210
ER
PT J
AU Cassetti, MC
Thomas, SJ
AF Cassetti, M. Cristina
Thomas, Stephen J.
TI Dengue Human Infection Model: Introduction
SO JOURNAL OF INFECTIOUS DISEASES
LA English
DT Article
ID VACCINE DEVELOPMENT; ANIMAL-MODELS; VIRUS; CHALLENGE; ETIOLOGY;
IMMUNITY; FEVER; PHASE
C1 [Cassetti, M. Cristina] NIAID, Virol Branch, Bethesda, MD 20892 USA.
[Thomas, Stephen J.] Walter Reed Army Inst Res, Viral Dis Branch, Silver Spring, MD 20910 USA.
RP Thomas, SJ (reprint author), Walter Reed Army Inst Res, Viral Dis Branch, 503 Robert Grant Ave, Silver Spring, MD 20910 USA.
EM stephen.j.thomas3.mil@mail.mil
NR 27
TC 5
Z9 5
U1 0
U2 6
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0022-1899
EI 1537-6613
J9 J INFECT DIS
JI J. Infect. Dis.
PD JUN 15
PY 2014
VL 209
SU 2
BP 537
EP 539
DI 10.1093/infdis/jiu061
PG 3
WC Immunology; Infectious Diseases; Microbiology
SC Immunology; Infectious Diseases; Microbiology
GA AI7JG
UT WOS:000337063800001
PM 24872393
ER
PT J
AU Spring, M
Polhemus, M
Ockenhouse, C
AF Spring, Michele
Polhemus, Mark
Ockenhouse, Christian
TI Controlled Human Malaria Infection
SO JOURNAL OF INFECTIOUS DISEASES
LA English
DT Article
DE malaria; challenge; efficacy; clinical trial; mosquito
ID FALCIPARUM CIRCUMSPOROZOITE VACCINE; INSTITUTE-OF-RESEARCH; PHASE 2A
TRIAL; PLASMODIUM-FALCIPARUM; NAIVE ADULTS; SPOROZOITE CHALLENGE;
PROTEIN VACCINE; EFFICACY; SAFETY; IMMUNOGENICITY
AB Background. Since 1986, investigators at Walter Reed Army Institute of Research (WRAIR) have been using controlled human malaria challenge (CHMI) in malaria-naive adults in order to define the protective efficacy of a malaria vaccine and thus guide programmatic decisions on vaccine candidates. Adapting this model to the dengue field could provide similar evidential support for a vaccine or therapeutic product.
Methods. After completing a vaccine regimen, volunteers are bitten by 5 malaria-infected female Anopheles mosquitoes in a controlled environment. Volunteers are then monitored daily for peripheral parasitemia in a hotel setting with 24-hour access to a nurse and physician. If a single verified parasite is detected, effective antimalarials are promptly administered.
Results. The vast majority of the over 1000 volunteers having participated in CHMI clinical studies have done so at US military research centers. Numerous pre-erythrocytic and erythrocytic vaccine candidates have been evaluated safely and without any related serious adverse events using this model, including the soon-to-be licensed RTS, S malaria vaccine.
Conclusion. The lessons learned from over 25 years of experience in consistent, careful preparation and execution of the CHMI model at WRAIR can provide a foundation from which the dengue field can begin to develop a rigorous and safe "CHDI" model.
C1 [Spring, Michele; Polhemus, Mark; Ockenhouse, Christian] Walter Reed Army Inst Res, US Mil Malaria Vaccine Program, Silver Spring, MD USA.
RP Spring, M (reprint author), AFRIMS, Dept Immunol & Med, 315-6 Rajivithi rD, Bangkok 10400, Thailand.
EM michele.spring@afrims.org
FU Military Infectious Disease Research Program; US Army Medical Research
and Materiel Activity of the US Medical Research and Materiel Command;
National Vaccine Program Office at US Department of Health and Human
Services; Malaria Vaccine Development Program at US Agency for
International Development; GlaxoSmithKline Biologicals; Program for
Appropriate Technology in Health (PATH) Malaria Vaccine Initiative;
National Institutes of Health
FX Financial support. The CHMI work conducted from 1986 to 2012 was
supported by the Military Infectious Disease Research Program and US
Army Medical Research and Materiel Activity of the US Medical Research
and Materiel Command, National Vaccine Program Office at US Department
of Health and Human Services, Malaria Vaccine Development Program at US
Agency for International Development, GlaxoSmithKline Biologicals,
Program for Appropriate Technology in Health (PATH) Malaria Vaccine
Initiative, and the National Institutes of Health.
NR 41
TC 19
Z9 19
U1 1
U2 8
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0022-1899
EI 1537-6613
J9 J INFECT DIS
JI J. Infect. Dis.
PD JUN 15
PY 2014
VL 209
SU 2
BP 540
EP 545
DI 10.1093/infdis/jiu063
PG 6
WC Immunology; Infectious Diseases; Microbiology
SC Immunology; Infectious Diseases; Microbiology
GA AI7JG
UT WOS:000337063800002
PM 24872394
ER
PT J
AU Eckels, KH
AF Eckels, Kenneth H.
TI Production and Testing of Dengue Virus Strains Suitable for Human
Infection Studies
SO JOURNAL OF INFECTIOUS DISEASES
LA English
DT Article
DE dengue virus strains; human challenge; vaccine efficacy
ID HUMAN CHALLENGE; RHESUS-MONKEYS; VACCINE; ATTENUATION; RECOMBINANT;
CANDIDATE; MODEL
AB Vaccine efficacy can be assessed in human subjects who have received dengue virus (DENV) candidate vaccines. Recent, published studies have been conducted with DENV strains that resulted in a spectrum of clinical disease. DENV-1 and DENV-3 strains were identified that could be used to test for protection against these serotypes. DENV strains that are intended for similar human clinical studies require production and preclinical testing that are the same as vaccines entering Phase 1 human clinical testing. Information on passage history, use of raw materials, testing for adventitious agents, complete characterization (including genetic sequence), and product stability are essential for DENV strain banks intended for human infection studies.
C1 [Eckels, Kenneth H.] Walter Reed Army Inst Res, Pilot Bioprod Facil, Silver Spring, MD 20910 USA.
RP Eckels, KH (reprint author), Walter Reed Army Inst Res, 503 Robert Grant Ave, Silver Spring, MD 20910 USA.
EM kenneth.h.eckels.civ@mail.mil
FU US Military Infectious Disease Research Program, US Army Medical
Research and Materiel Command (USAMRMC), Fort Detrick, Maryland
FX Financial support. This work was supported by the US Military Infectious
Disease Research Program, US Army Medical Research and Materiel Command
(USAMRMC), Fort Detrick, Maryland.
NR 15
TC 1
Z9 1
U1 0
U2 2
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0022-1899
EI 1537-6613
J9 J INFECT DIS
JI J. Infect. Dis.
PD JUN 15
PY 2014
VL 209
SU 2
BP 546
EP 548
DI 10.1093/infdis/jiu161
PG 3
WC Immunology; Infectious Diseases; Microbiology
SC Immunology; Infectious Diseases; Microbiology
GA AI7JG
UT WOS:000337063800003
PM 24872395
ER
PT J
AU Mores, CN
Christofferson, RC
Davidson, SA
AF Mores, Christopher N.
Christofferson, Rebecca C.
Davidson, Silas A.
TI The Role of the Mosquito in a Dengue Human Infection Model
SO JOURNAL OF INFECTIOUS DISEASES
LA English
DT Article
DE Infection model; dengue virus; mosquito; allergic response; innate
immunity; humoral immunity; dengue model; dengue vaccine
ID WEST-NILE-VIRUS; AEDES-AEGYPTI MOSQUITOS; VECTOR COMPETENCE; LABORATORY
TRANSMISSION; PLASMODIUM-FALCIPARUM; JAPANESE ENCEPHALITIS; VACCINE
DEVELOPMENT; INFORMATION-SYSTEM; INDUCED HEMORRHAGE; ARTHROPOD SALIVA
AB Recent efforts to combat the growing global threat of dengue disease, including deployment of phase IIb vaccine trials, has continued to be hindered by uncertainty surrounding equitable immune responses of serotypes, relative viral fitness of vaccine vs naturally occurring strains, and the importance of altered immune environments due to natural delivery routes. Human infection models can significantly improve our understanding of the importance of certain phenotypic characteristics of viral strains, and inform strain selection and trial design. With human models, we can further assess the importance of the natural delivery route of DENV and/or the accompanying mosquito salivary milieu. Accordingly, we discuss the use of mosquitoes in such a human infection model with DENV, identify important considerations, and make preliminary recommendations for deployment of such a mosquito improved DENV human infection model (miDHIM).
C1 [Mores, Christopher N.; Christofferson, Rebecca C.] LSU, Sch Vet Med, Dept Pathobiol Sci, Baton Rouge, LA 70803 USA.
[Davidson, Silas A.] Walter Reed Army Inst Res, Dept Entomol, Silver Spring, MD USA.
RP Mores, CN (reprint author), LSU, Sch Vet Med, Dept Pathobiol Sci, Skip Bertman Dr, Baton Rouge, LA 70803 USA.
EM cmores@lsu.edu
FU NIH/NIGMS [U01GM097661, P20GM103458]
FX Financial support. This work was supported by NIH/NIGMS U01GM097661 and
NIH/NIGMS P20GM103458.
NR 75
TC 6
Z9 6
U1 2
U2 24
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0022-1899
EI 1537-6613
J9 J INFECT DIS
JI J. Infect. Dis.
PD JUN 15
PY 2014
VL 209
SU 2
BP 571
EP 578
DI 10.1093/infdis/jiu110
PG 8
WC Immunology; Infectious Diseases; Microbiology
SC Immunology; Infectious Diseases; Microbiology
GA AI7JG
UT WOS:000337063800008
PM 24872400
ER
PT J
AU Zhang, YS
Zhu, YB
Gupta, A
Huang, YY
Murray, CK
Vrahas, MS
Sherwood, ME
Baer, DG
Hamblin, MR
Dai, TH
AF Zhang, Yunsong
Zhu, Yingbo
Gupta, Asheesh
Huang, Yingying
Murray, Clinton K.
Vrahas, Mark S.
Sherwood, Margaret E.
Baer, David G.
Hamblin, Michael R.
Dai, Tianhong
TI Antimicrobial Blue Light Therapy for Multidrug-Resistant Acinetobacter
baumannii Infection in a Mouse Burn Model: Implications for Prophylaxis
and Treatment of Combat-related Wound Infections
SO JOURNAL OF INFECTIOUS DISEASES
LA English
DT Article
DE Blue light; Acinetobacter baumannii; burn; infection; multidrug
resistance; mouse model
ID MRSA IN-VITRO; STAPHYLOCOCCUS-AUREUS; PHOTODYNAMIC THERAPY;
VISIBLE-LIGHT; BACTERIA; INACTIVATION; AFGHANISTAN; PORPHYRINS; 405-NM;
MICE
AB In this study, we investigated the utility of antimicrobial blue light therapy for multidrug-resistant Acinetobacter baumannii infection in a mouse burn model. A bioluminescent clinical isolate of multidrug-resistant A. baumannii was obtained. The susceptibility of A. baumannii to blue light (415 nm)-inactivation was compared in vitro to that of human keratinocytes. Repeated cycles of sublethal inactivation of bacterial by blue light were performed to investigate the potential resistance development of A. baumannii to blue light. A mouse model of third degree burn infected with A. baumannii was developed. A single exposure of blue light was initiated 30 minutes after bacterial inoculation to inactivate A. baumannii in mouse burns. It was found that the multidrug-resistant A. baumannii strain was significantly more susceptible than keratinocytes to blue light inactivation. Transmission electron microscopy revealed blue light-induced ultrastructural damage in A. baumannii cells. Fluorescence spectroscopy suggested that endogenous porphyrins exist in A. baumannii cells. Blue light at an exposure of 55.8 J/cm(2) significantly reduced the bacterial burden in mouse burns. No resistance development to blue light inactivation was observed in A. baumannii after 10 cycles of sublethal inactivation of bacteria. No significant DNA damage was detected in mouse skin by means of a skin TUNEL assay after a blue light exposure of 195 J/cm(2).
C1 [Zhang, Yunsong; Zhu, Yingbo; Gupta, Asheesh; Huang, Yingying; Sherwood, Margaret E.; Hamblin, Michael R.; Dai, Tianhong] Massachusetts Gen Hosp, Wellman Ctr Photomed, Boston, MA 02114 USA.
[Vrahas, Mark S.] Massachusetts Gen Hosp, Dept Orthopaed Surg, Boston, MA 02114 USA.
[Zhang, Yunsong; Gupta, Asheesh; Huang, Yingying; Hamblin, Michael R.; Dai, Tianhong] Harvard Univ, Sch Med, Dept Dermatol, Boston, MA 02115 USA.
[Hamblin, Michael R.] MIT, Harvard Mit Div Hlth Sci & Technol, Cambridge, MA 02139 USA.
[Murray, Clinton K.] Brooke Army Med Ctr, Infect Dis Serv, Ft Sam Houston, TX 78234 USA.
[Baer, David G.] US Army Inst Surg Res, Ft Sam Houston, TX USA.
[Zhang, Yunsong] Jinan Univ, Dept Burn & Plast Surg, Guangzhou Red Cross Hosp, Guangzhou, Guangdong, Peoples R China.
[Zhu, Yingbo] Tongji Univ, Sch Med, Shanghai 200092, Peoples R China.
[Gupta, Asheesh] Def Inst Physiol & Allied Sci, Delhi, India.
RP Dai, TH (reprint author), Massachusetts Gen Hosp, Wellman Ctr Photomed, BAR 404B,55 Fruit St, Boston, MA 02114 USA.
EM tdai@mgh.harvard.edu
OI Hamblin, Michael/0000-0001-6431-4605
FU Center for Integration of Medicine and Innovative Technology (CIMIT)
under a US Army Medical Research Acquisition Activity [13-1033];
COTA/Smith and Nephew [2012-16]; Airlift Research Foundation [109421];
National Institutes of Health [RO1AI050875]
FX This work was supported by the Center for Integration of Medicine and
Innovative Technology (CIMIT) under a US Army Medical Research
Acquisition Activity cooperative agreement (CIMIT no. 13-1033 to T. D.),
COTA/Smith and Nephew (grant 2012-16 to T. D.), the Airlift Research
Foundation (Extremity Trauma Research Grant 109421 to T. D.), and the
National Institutes of Health (grant RO1AI050875 to M. R. H.).
NR 34
TC 18
Z9 19
U1 0
U2 31
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0022-1899
EI 1537-6613
J9 J INFECT DIS
JI J. Infect. Dis.
PD JUN 15
PY 2014
VL 209
IS 12
BP 1963
EP 1971
DI 10.1093/infdis/jit842
PG 9
WC Immunology; Infectious Diseases; Microbiology
SC Immunology; Infectious Diseases; Microbiology
GA AI7JB
UT WOS:000337063100015
PM 24381206
ER
PT J
AU Touryan, J
Apker, G
Lance, BJ
Kerick, SE
Ries, AJ
McDowell, K
AF Touryan, Jon
Apker, Gregory
Lance, Brent J.
Kerick, Scott E.
Ries, Anthony J.
McDowell, Kaleb
TI Estimating endogenous changes in task performance from EEG
SO FRONTIERS IN NEUROSCIENCE
LA English
DT Article
ID INDEPENDENT COMPONENT ANALYSIS; COUPLED COMPUTER VISION; SPECTRAL
COMPONENTS; ALPHA OSCILLATIONS; DRIVER SLEEPINESS; FATIGUE; TIME;
ATTENTION; SYSTEM; SYNCHRONIZATION
AB Brain wave activity is known to correlate with decrements in behavioral performance as individuals enter states of fatigue, boredom, or low alertness.Many BCI technologies are adversely affected by these changes in user state, limiting their application and constraining their use to relatively short temporal epochs where behavioral performance is likely to be stable. Incorporating a passive BCI that detects when the user is performing poorly at a primary task, and adapts accordingly may prove to increase overall user performance. Here, we explore the potential for extending an established method to generate continuous estimates of behavioral performance from ongoing neural activity; evaluating the extended method by applying it to the original task domain, simulated driving; and generalizing the method by applying it to a BCI-relevant perceptual discrimination task. Specifically, we used EEG log power spectra and sequential forward floating selection (SFFS) to estimate endogenous changes in behavior in both a simulated driving task and a perceptual discrimination task. For the driving task the average correlation coefficient between the actual and estimated lane deviation was 0.37 +/- 0.22 (mu +/- s). For the perceptual discrimination task we generated estimates of accuracy, reaction time, and button press duration for each participant. The correlation coefficients between the actual and estimated behavior were similar for these three metrics (accuracy = 0.25 +/- 0.37, reaction time = 0.33 +/- 0.23, button press duration = 0.36 +/- 0.30). These findings illustrate the potential for modeling time-on-task decrements in performance from concurrent measures of neural activity.
C1 [Touryan, Jon; Apker, Gregory; Lance, Brent J.; Kerick, Scott E.; Ries, Anthony J.; McDowell, Kaleb] US Army, Res Lab, Human Res Engn Directorate, Aberdeen Proving Ground, MD 21005 USA.
RP Touryan, J (reprint author), US Army, Res Lab, Human Res Engn Directorate, RDRL HRS C, Aberdeen Proving Ground, MD 21005 USA.
EM jonathan.o.touryan.ctr@mail.mil
FU Army Research Laboratory [W911NF-12-2-0019]
FX Research was sponsored by the Army Research Laboratory and was
accomplished under Cooperative Agreement Number W911NF-12-2-0019. The
views and conclusions contained in this document are those of the
authors and should not be interpreted as representing the official
policies, either expressed or implied, of the Army Research Laboratory
or U.S. Government. The U.S. Government is authorized to reproduce and
distribute reprints for Government purposes not with standing any
copyright notation herein. The authors would like to thank T. Johnson,
M. Cannon, M. Jaswa, C. Manteuffel, and J. Sidman for their help
developing the driving simulator. We would also like to thank P. Weber
for developing the RSVP display software; L. Gibson and K. Turner for
creating the RSVP stimuli; C. Argys, K. Corby and T. Chiappone for
running the experiments.
NR 64
TC 6
Z9 6
U1 4
U2 15
PU FRONTIERS RESEARCH FOUNDATION
PI LAUSANNE
PA PO BOX 110, LAUSANNE, 1015, SWITZERLAND
SN 1662-453X
J9 FRONT NEUROSCI-SWITZ
JI Front. Neurosci.
PD JUN 13
PY 2014
VL 8
AR 155
DI 10.3389/fnins.2014.00155
PG 17
WC Neurosciences
SC Neurosciences & Neurology
GA AW8DQ
UT WOS:000346491300001
PM 24994968
ER
PT J
AU Campbell, JE
Meledeo, MA
Cap, AP
AF Campbell, James E.
Meledeo, Michael Adam
Cap, Andrew P.
TI Comparative Response of Platelet fV and Plasma fV to Activated Protein C
and Relevance to a Model of Acute Traumatic Coagulopathy
SO PLOS ONE
LA English
DT Article
ID TISSUE FACTOR PATHWAY; FACTOR VA INACTIVATION; COAGULATION-FACTOR-V;
THROMBIN GENERATION; IN-VITRO; BLOOD-COAGULATION; SEVERE SEPSIS;
FACTOR-VIII; RECEPTOR; MECHANISMS
AB Background: Acute traumatic coagulopathy (ATC) has been linked to an increase in activated protein C (aPC) from 40 pM in healthy individuals to 175 pM. aPC exerts its activity primarily through cleavage of active coagulation factor Va (fVa). Platelets reportedly possess fVa which is more resistant to aPC cleavage than plasma fVa; this work examines the hypothesis that normal platelets are sufficient to maintain coagulation in the presence of elevated aPC.
Methods: Coagulation responses of normal plasma, fV deficient plasma (fVdp), and isolated normal platelets in fVdp were conducted: prothrombin (PT) tests, turbidimetry, and thromboelastography (TEG), including the dose response of aPC on the samples.
Results: PT and turbidimetric assays demonstrate that normal plasma is resistant to aPC at doses much higher than those found in ATC. Additionally, an average physiological number of washed normal platelets (200,000 platelets/mm(3)) was sufficient to eliminate the anti-coagulant effects of aPC up to 10 nM, nearly two orders of magnitude above the ATC concentration and even the steady-state pharmacological concentration of human recombinant aPC, as measured by TEG. aPC also demonstrated no significant effect on clot lysis in normal plasma samples with or without platelets.
Conclusions: Although platelet fVa shows slightly superior resistance to aPC's effects compared to plasma fVa in static models, neither fVa is sufficiently cleaved in simulations of ATC or pharmacologically-delivered aPC to diminish coagulation parameters. aPC is likely a correlative indicator of ATC or may play a cooperative role with other activity altering products generated in ATC.
C1 [Campbell, James E.; Meledeo, Michael Adam; Cap, Andrew P.] JBSA FT Sam Houston, Coagulat & Blood Res Program, US Army Inst Surg Res, Houston, TX 78234 USA.
RP Meledeo, MA (reprint author), JBSA FT Sam Houston, Coagulat & Blood Res Program, US Army Inst Surg Res, Houston, TX 78234 USA.
EM michael.a.meledeo.vol@mail.mil
OI Meledeo, Michael/0000-0001-9958-9115
FU Combat Casualty Care Research Program of the United States Army Medical
Research and Materiel Command [B_040_011]
FX Funding for this project was provided by the Combat Casualty Care
Research Program of the United States Army Medical Research and Materiel
Command, proposal designation B_040_011. https://ccc.amedd.army.mil/.
The funders had no role in study design, data collection and analysis,
decision to publish, or preparation of the manuscript.
NR 70
TC 12
Z9 12
U1 0
U2 6
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD JUN 12
PY 2014
VL 9
IS 6
AR e99181
DI 10.1371/journal.pone.0099181
PG 10
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA AK8TP
UT WOS:000338701300040
PM 24921658
ER
PT J
AU Steers, NJ
Currier, JR
Jobe, O
Tovanabutra, S
Ratto-Kim, S
Marovich, MA
Kim, JH
Michael, NL
Alving, CR
Rao, M
AF Steers, Nicholas J.
Currier, Jeffrey R.
Jobe, Ousman
Tovanabutra, Sodsai
Ratto-Kim, Silvia
Marovich, Mary A.
Kim, Jerome H.
Michael, Nelson L.
Alving, Carl R.
Rao, Mangala
TI Designing the epitope flanking regions for optimal generation of CTL
epitopes
SO VACCINE
LA English
DT Article
DE HIV-1; Gag-p24; Proteasome; CTL-epitope; Synthetic flanking region;
Immunogen design
ID T-CELL EPITOPES; MEDIATED ANTIGEN PRESENTATION; THIMET OLIGOPEPTIDASE;
LYMPHOCYTE RESPONSES; HIV-1 INFECTION; IN-VITRO; PROTEASOME; VIRUS;
SEQUENCES; PEPTIDES
AB The flanking amino acids that surround epitopes are critical for effective antigen processing and maintenance of epitope integrity. In the present study, the frequency and characteristics of each amino acid that flanked the peptides generated from the proteasomal degradation of three different subtypes of HIV-1 Gag-p24 were determined. Synthetic flanking regions were designed based on the highest and the lowest frequencies of amino acid with the ideal characteristics at positions upstream and downstream of the proteasomal cleavage site. Peptides were synthesized that contained known CD8+ CTL-epitopes from HIV-1 Gag, CMV pp65, and vaccinia proteins HRP-2, and C16, flanked by amino acid sequences specifically designed to either generate or inhibit the known CD8+ CTL-epitopes. As predicted, the known CD8+ CTL-epitopes were effectively generated from the peptides with synthetic flanking regions specifically designed to promote epitope generation in a proteasome-dependent manner. The majority of the proteasome-generated epitopes were cleaved immediately after the C-terminal amino acid of the specific CTL-epitope. The synthetic peptide sequences containing known CD8+ CTL-epitopes with the flanking regions that promote epitope generation were effectively processed and presented to epitope specific CD8+ T-cells resulting in the production of IFN-gamma. These results highlight the importance of flanking regions in promoting efficient antigen processing and presentation. This concept can have important implications in vaccine design and development strategies. Published by Elsevier Ltd.
C1 [Steers, Nicholas J.; Currier, Jeffrey R.; Jobe, Ousman; Tovanabutra, Sodsai; Ratto-Kim, Silvia; Marovich, Mary A.; Kim, Jerome H.; Michael, Nelson L.; Alving, Carl R.; Rao, Mangala] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD 20910 USA.
[Steers, Nicholas J.; Currier, Jeffrey R.; Jobe, Ousman; Tovanabutra, Sodsai; Ratto-Kim, Silvia] Henry M Jackson Fdn Adv Mil Med, Rockledge, MD 20852 USA.
RP Rao, M (reprint author), Walter Reed Army Inst Res, USMHRP, Lab Adjuvant & Antigen Res, 503 Robert Grant Ave,Rm 2A09, Silver Spring, MD 20910 USA.
EM mrao@hivresearch.org
FU Henry M. Jackson Foundation for the Advancement of Military Medicine,
Inc. [W81XWH-07-2-0067]; U.S. Department of Defense (DOD)
[W81XWH-07-2-0067]
FX This work was supported by a cooperative agreement (W81XWH-07-2-0067)
between the Henry M. Jackson Foundation for the Advancement of Military
Medicine, Inc., and the U.S. Department of Defense (DOD).
NR 48
TC 2
Z9 2
U1 2
U2 7
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0264-410X
EI 1873-2518
J9 VACCINE
JI Vaccine
PD JUN 12
PY 2014
VL 32
IS 28
BP 3509
EP 3516
DI 10.1016/j.vaccine.2014.04.039
PG 8
WC Immunology; Medicine, Research & Experimental
SC Immunology; Research & Experimental Medicine
GA AL0NC
UT WOS:000338822600007
PM 24795226
ER
PT J
AU Pondo, T
Rose, CE
Martin, SW
Keitel, WA
Keyserling, HL
Babcock, J
Parker, S
Jacobson, RM
Poland, GA
McNeil, MM
AF Pondo, Tracy
Rose, Charles E., Jr.
Martin, Stacey W.
Keitel, Wendy A.
Keyserling, Harry L.
Babcock, Janiine
Parker, Scott
Jacobson, Robert M.
Poland, Gregory A.
McNeil, Michael M.
TI Evaluation of sex, race, body mass index and pre-vaccination serum
progesterone levels and post-vaccination serum anti-anthrax protective
immunoglobulin G on injection site adverse events following anthrax
vaccine adsorbed (AVA) in the CDC AVA human clinical trial
SO VACCINE
LA English
DT Article
DE Anthrax vaccine adsorbed; Anthrax vaccines/adverse events; Sex factors;
Race; Body mass index; Immunological response
ID IMMUNE-RESPONSES; RANDOMIZED-TRIAL; SAFETY PROFILE; IMMUNOGENICITY;
DISABILITY; IMMUNIZATION; PREGNANCY; HORMONES; GENDER; SYSTEM
AB Background: Anthrax vaccine adsorbed (AVA) administered intramuscularly (IM) results in fewer adverse events (AEs) than subcutaneous (SQ) administration. Women experience more AEs than men. Antibody response, female hormones, race, and body mass index (BMI) may contribute to increased frequency of reported injection site AEs.
Methods: We analyzed data from the CDC AVA human clinical trial. This double blind, randomized, placebo controlled trial enrolled 1563 participants and followed them through 8 injections (AVA or placebo) over a period of 42 months. For the trial's vaccinated cohort (n = 1267), we used multivariable logistic regression to model the effects of study group (SQ or IM), sex, race, study site, BMI, age, and post-vaccination serum anti-PA IgG on occurrence of AEs of any severity grade. Also, in a women-only subset (n = 227), we assessed effect of pre-vaccination serum progesterone level and menstrual phase on AEs.
Results: Participants who received SQ injections had significantly higher proportions of itching, redness, swelling, tenderness and warmth compared to the IM study group after adjusting for other risk factors. The proportions of redness, swelling, tenderness and warmth were all significantly lower in blacks vs. non-black participants. We found arm motion limitation, itching, pain, swelling and tenderness were more likely to occur in participants with the highest anti-PA IgG concentrations. In the SQ study group, redness and swelling were more common for obese participants compared to participants who were not overweight. Females had significantly higher proportions of all AEs compared to males. Menstrual phase was not associated with any AEs.
Conclusions: Female and non-black participants had a higher proportion of AVA associated AEs and higher anti-PA IgG concentrations. Antibody responses to other vaccines may also vary by sex and race. Further studies may provide better understanding for higher proportions of AEs in women and non-black participants. Published by Elsevier Ltd.
C1 [Pondo, Tracy; Rose, Charles E., Jr.; Martin, Stacey W.] Ctr Dis Control & Prevent, Natl Ctr Immunizat & Resp Dis, Div Bacterial Dis, Atlanta, GA 30333 USA.
[McNeil, Michael M.] Ctr Dis Control & Prevent, Div Healthcare Qual Promot, Immunizat Safety Off, Atlanta, GA USA.
[Keitel, Wendy A.] Baylor Coll Med, Houston, TX 77030 USA.
[Keyserling, Harry L.] Emory Univ, Sch Med, Atlanta, GA USA.
[Babcock, Janiine] Walter Reed Army Med Ctr, Walter Reed Army Inst Res, Washington, DC 20307 USA.
[Parker, Scott] Univ Alabama Birmingham, Birmingham, AL USA.
[Jacobson, Robert M.; Poland, Gregory A.] Mayo Clin, Rochester, MN USA.
RP Pondo, T (reprint author), Ctr Dis Control & Prevent, Natl Ctr Immunizat & Resp Dis, Div Bacterial Dis, Atlanta, GA 30333 USA.
EM dio2@cdc.gov
FU CDC
FX The protocol for this study was approved by an Institutional Review
Board of the Centers for Disease Control and Prevention (CDC). The
funding for this study was provided solely by the CDC.
NR 44
TC 10
Z9 10
U1 1
U2 2
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0264-410X
EI 1873-2518
J9 VACCINE
JI Vaccine
PD JUN 12
PY 2014
VL 32
IS 28
BP 3548
EP 3554
DI 10.1016/j.vaccine.2014.04.025
PG 7
WC Immunology; Medicine, Research & Experimental
SC Immunology; Research & Experimental Medicine
GA AL0NC
UT WOS:000338822600012
PM 24768633
ER
PT J
AU DeCoste, JB
Peterson, GW
AF DeCoste, Jared B.
Peterson, Gregory W.
TI Metal-Organic Frameworks for Air Purification of Toxic Chemicals
SO CHEMICAL REVIEWS
LA English
DT Review
ID COORDINATIVELY UNSATURATED SITES; ZEOLITIC IMIDAZOLATE FRAMEWORKS;
MOF/GRAPHITE OXIDE COMPOSITES; HYDROGEN-SULFIDE ADSORPTION; CU-BTC;
REACTIVE ADSORPTION; CARBON-MONOXIDE; XYLENE ISOMERS; WARFARE AGENTS;
ZIRCONIUM HYDROXIDE
C1 [DeCoste, Jared B.] Leidos Inc, Gunpowder, MD 21010 USA.
[Peterson, Gregory W.] US Army Res Dev & Engn Command, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA.
RP DeCoste, JB (reprint author), Leidos Inc, POB 68, Gunpowder, MD 21010 USA.
EM jared.b.decoste2.ctr@mail.mil; gregory.w.peterson.civ@mail.mil
FU Joint Science and Technology Office for Chemical Biological Defense
(JSTO-CBD) [BA07PRO104]
FX The authors thank the Joint Science and Technology Office for Chemical
Biological Defense (JSTO-CBD) for funding this review, under Project
Number BA07PRO104, and David Tevault for technical editing. Gas mask
photograph in the table of contents and cover graphics courtesy of the
U.S. Army.
NR 224
TC 177
Z9 177
U1 65
U2 426
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0009-2665
EI 1520-6890
J9 CHEM REV
JI Chem. Rev.
PD JUN 11
PY 2014
VL 114
IS 11
BP 5695
EP 5727
DI 10.1021/cr4006473
PG 33
WC Chemistry, Multidisciplinary
SC Chemistry
GA AJ0JJ
UT WOS:000337336500003
PM 24750116
ER
PT J
AU Suleiman, D
Padovani, AM
Negron, AA
Sloan, JM
Napadensky, E
Crawford, DM
AF Suleiman, David
Padovani, Agnes M.
Negron, Arnaldo A.
Sloan, James M.
Napadensky, Eugene
Crawford, Dawn M.
TI Mechanical and Chemical Properties of Poly( styrene- isobutylenestyrene)
Block Copolymers: Effect of Sulfonation and Counter Ion Substitution
SO JOURNAL OF APPLIED POLYMER SCIENCE
LA English
DT Article
DE elastomers; mechanical properties; nanostructured polymers; properties
and characterization; structure-property relations
ID METHANOL FUEL-CELLS; X-RAY-SCATTERING; TRIBLOCK COPOLYMER;
THERMOGRAVIMETRIC CHARACTERIZATION; ELECTROLYTE MEMBRANES;
TRANSPORT-PROPERTIES; EXCHANGE CAPACITIES; IONOMERS; NANOINDENTATION;
MORPHOLOGY
AB In this study, the mechanical and chemical properties of a series of sulfonated poly(styrene-isobutylene-styrene) (SIBS) block copolymers were evaluated using a combination of nanoindentation, dynamic mechanical analysis (DMA), elemental analysis (EA), Fourier transform infrared spectroscopy (FTIR), water absorption, and small angle X-ray scattering studies (SAXS). The materials properties were characterized as a function of the sulfonation percent in the block copolymers, as well as a result of the counter-ion substitution with Mg2+, Ca2+, and Ba2+. Nanoindentation studies revealed that the elastic modulus (E) and hardness (H) increase with sulfonation up to a certain level, at which point, the effect of water content further hinders any mechanical reinforcement. The incorporation of counter-ions increases E and H, but the results are dependent upon the size of the counter-ion. DMA results showed that the polymer maintained the glass transition temperature (T-g) of the polyisobutylene (PIB) segment (-60 degrees C) regardless of the sulfonation level or counter-ion substituted. However, both the shoulder of the PIB T-g (-30 degrees C), which was probably caused by a Rouse-type motion, as well as the T-g of polystyrene (105 degrees C) disappeared upon sulfonation. Counter-ion substitution increased the storage modulus of the rubbery plateau, which is indicative of a stronger and more thermally stable crosslinked complex formation. Additional unique relaxations were observed with the counter-ions, and could be attributed to the stretching/rotation of the SO bond and the interaction of the cations with the oxygen in the sulfonic group. FTIR results also revealed a unique shifting of the asymmetric SO band when counter-ions were added. (c) 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014, 131, 40344.
C1 [Suleiman, David; Padovani, Agnes M.; Negron, Arnaldo A.] Univ Puerto Rico, Dept Chem Engn, Mayaguez, PR 00681 USA.
[Padovani, Agnes M.] Univ Puerto Rico, Engn Sci & Mat Dept, Mayaguez, PR 00681 USA.
[Sloan, James M.; Napadensky, Eugene; Crawford, Dawn M.] US Army Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA.
RP Suleiman, D (reprint author), Univ Puerto Rico, Dept Chem Engn, Mayaguez, PR 00681 USA.
EM David.Suleiman@upr.edu
FU Department of Defense (DOD) of the United States [W911-NF-11-10486];
National Science Foundation (NSF) [HRD-0833112 (CREST), DMR-0922994
(MRI)]
FX This investigation was partially supported by the Department of Defense
(DOD) of the United States through grant number W911-NF-11-10486 and the
National Science Foundation (NSF) under grants HRD-0833112 (CREST) and
DMR-0922994 (MRI). The authors would also like to acknowledge the
support of Prof. Danilo C. Pozzo, of the University of Washington, and
his research group, especially Pablo De La Iglesia, where the SAXS
experiments were conducted (NSF DMR 0817622). Finally, the authors would
like to acknowledge Ms. Sonia L. Aviles Barreto for her contributions.
NR 36
TC 1
Z9 1
U1 2
U2 59
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0021-8995
EI 1097-4628
J9 J APPL POLYM SCI
JI J. Appl. Polym. Sci.
PD JUN 5
PY 2014
VL 131
IS 11
AR 40344
DI 10.1002/app.40344
PG 8
WC Polymer Science
SC Polymer Science
GA AC3AL
UT WOS:000332387300044
ER
PT J
AU Murphy, JR
Weiss, WR
Fryauff, D
Dowler, M
Savransky, T
Stoyanov, C
Muratova, O
Lambert, L
Orr-Gonzalez, S
Zeleski, KL
Hinderer, J
Fay, MP
Joshi, G
Gwadz, RW
Richie, TL
Villasante, EF
Richardson, JH
Duffy, PE
Chen, JY
AF Murphy, Jittawadee R.
Weiss, Walter R.
Fryauff, David
Dowler, Megan
Savransky, Tatyana
Stoyanov, Cristina
Muratova, Olga
Lambert, Lynn
Orr-Gonzalez, Sachy
Zeleski, Katie Lynn
Hinderer, Jessica
Fay, Michael P.
Joshi, Gyan
Gwadz, Robert W.
Richie, Thomas L.
Villasante, Eileen Franke
Richardson, Jason H.
Duffy, Patrick E.
Chen, Jingyang
TI Using infective mosquitoes to challenge monkeys with Plasmodium knowlesi
in malaria vaccine studies
SO MALARIA JOURNAL
LA English
DT Article
DE Monkey; Rhesus; Macaca mulatta; Plasmodium knowlesi; Anopheles dirus;
Anopheles crascens; Vaccine; Methylparaben; Mosquito; Challenge
ID ANOPHELES-BALABACENSIS-BALABACENSIS; BLOOD-STAGE ANTIGENS;
RHESUS-MONKEYS; BERGHEI SPOROZOITES; PROTECTION; FALCIPARUM; SURVIVAL;
SKIN; TRANSMISSION; MACAQUES
AB Background: When rhesus monkeys (Macaca mulatta) are used to test malaria vaccines, animals are often challenged by the intravenous injection of sporozoites. However, natural exposure to malaria comes via mosquito bite, and antibodies can neutralize sporozoites as they traverse the skin. Thus, intravenous injection may not fairly assess humoral immunity from anti-sporozoite malaria vaccines. To better assess malaria vaccines in rhesus, a method to challenge large numbers of monkeys by mosquito bite was developed.
Methods: Several species and strains of mosquitoes were tested for their ability to produce Plasmodium knowlesi sporozoites. Donor monkey parasitaemia effects on oocyst and sporozoite numbers and mosquito mortality were documented. Methylparaben added to mosquito feed was tested to improve mosquito survival. To determine the number of bites needed to infect a monkey, animals were exposed to various numbers of P. knowlesi-infected mosquitoes. Finally, P. knowlesi-infected mosquitoes were used to challenge 17 monkeys in a malaria vaccine trial, and the effect of number of infectious bites on monkey parasitaemia was documented.
Results: Anopheles dirus, Anopheles crascens, and Anopheles dirus X (a cross between the two species) produced large numbers of P. knowlesi sporozoites. Mosquito survival to day 14, when sporozoites fill the salivary glands, averaged only 32% when donor monkeys had a parasitaemia above 2%. However, when donor monkey parasitaemia was below 2%, mosquitoes survived twice as well and contained ample sporozoites in their salivary glands. Adding methylparaben to sugar solutions did not improve survival of infected mosquitoes. Plasmodium knowlesi was very infectious, with all monkeys developing blood stage infections if one or more infected mosquitoes successfully fed. There was also a dose-response, with monkeys that received higher numbers of infected mosquito bites developing malaria sooner.
Conclusions: Anopheles dirus, An. crascens and a cross between these two species all were excellent vectors for P. knowlesi. High donor monkey parasitaemia was associated with poor mosquito survival. A single infected mosquito bite is likely sufficient to infect a monkey with P. knowlesi. It is possible to efficiently challenge large groups of monkeys by mosquito bite, which will be useful for P. knowlesi vaccine studies.
C1 [Murphy, Jittawadee R.; Dowler, Megan; Savransky, Tatyana; Richardson, Jason H.] Walter Reed Army Inst Res, Silver Spring, MD USA.
[Weiss, Walter R.; Fryauff, David; Richie, Thomas L.; Villasante, Eileen Franke] Naval Med Res Ctr, Silver Spring, MD 20910 USA.
[Stoyanov, Cristina; Muratova, Olga; Lambert, Lynn; Orr-Gonzalez, Sachy; Zeleski, Katie Lynn; Hinderer, Jessica; Duffy, Patrick E.; Chen, Jingyang] NIAID, NIH, Lab Malaria Immunol & Vaccinol, Rockville, MD USA.
[Fay, Michael P.] NIAID, NIH, Div Clin Res, Biostat Res Branch, Bethesda, MD 20892 USA.
[Joshi, Gyan] SAIC Frederick Inc, Frederick Natl Lab Canc Res, Frederick, MD 21702 USA.
[Gwadz, Robert W.] NIAID, NIH, Lab Malaria & Vector Res, Rockville, MD USA.
RP Weiss, WR (reprint author), Naval Med Res Ctr, Silver Spring, MD 20910 USA.
EM walter.weiss@verizon.net
OI Fay, Michael P./0000-0002-8643-9625; Richie, Thomas/0000-0002-2946-5456
FU NIH [1R01AI068761-01A2]; PATH/MVI [COL-CRADA 7872]; Malaria Research and
Reference Reagent Resource Center [HHSN272201000027C]; Intramural
Research Program of NIAID; Naval Medical Research Center by the U.S.
Army Medical Research Materiel Command [6000.RAD1.F.A0309]
FX We thank Paul Howell, Kevin Lee and Andre Laughinghouse for their help
producing mosquitoes for these experiments. Financial support was
provided by NIH grant # 1R01AI068761-01A2, PATH/MVI grant # COL-CRADA
7872, Malaria Research and Reference Reagent Resource Center grant
HHSN272201000027C, the Intramural Research Program of NIAID, and funds
allocated to the Naval Medical Research Center by the U.S. Army Medical
Research Materiel Command (work unit 6000.RAD1.F. A0309). The views
expressed in this article are those of the author and do not necessarily
reflect the official policy or position of the Department of the Navy,
Department of Defense, nor the U.S. Government. Title 17 U.S.C. 105
provides that 'Copyright protection under this title is not available
for any work of the United States Government.' The experiments reported
herein were conducted in compliance with the Animal Welfare Act and in
accordance with the principles set forth in the "Guide for the Care and
Use of Laboratory Animals," Institute of Laboratory Animals Resources,
National Research Council, National Academy Press, 1996.
NR 51
TC 3
Z9 3
U1 0
U2 9
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1475-2875
J9 MALARIA J
JI Malar. J.
PD JUN 3
PY 2014
VL 13
AR 215
DI 10.1186/1475-2875-13-215
PG 11
WC Infectious Diseases; Parasitology; Tropical Medicine
SC Infectious Diseases; Parasitology; Tropical Medicine
GA AL1PL
UT WOS:000338897300004
PM 24893777
ER
PT J
AU Thomas, C
Butler, A
Larson, S
Medina, V
Begonia, M
AF Thomas, Catherine
Butler, Afrachanna
Larson, Steven
Medina, Victor
Begonia, Maria
TI COMPLEXATION OF LEAD BY BERMUDA GRASS ROOT EXUDATES IN AQUEOUS MEDIA
SO INTERNATIONAL JOURNAL OF PHYTOREMEDIATION
LA English
DT Article
DE Lead; complexation; Bermuda grass; root exudates
ID RHIZOSPHERE
AB Exudates produced from Bermuda grass roots were collected in deionized water from sterilized Bermuda grass sod at 3-day intervals over a period of 15days. Exudates were analyzed for total organic carbon, and characterized via Fourier Transform Infrared Spectroscopy. Exudate samples were adjusted to pH values of 4.5, 6.5, and 7.5, amended with lead and quantified for soluble and complexed lead via Inductively Coupled PlasmaOptical Emission Spectrometry. Data obtained from total organic carbon measurements indicated compositional changes in Bermuda grass root exudates as organic carbon concentrations increased over time. Analysis of the infrared spectroscopy data indicated that carboxylic acids and amine functional groups were present in root exudates. Also, the ability of root-exuded compounds to solubilize lead in aqueous media was demonstrated as exudate samples dissolved an average of 60% more lead than deionized water. At pH values 4.5 and 7.5, lead complexation by Bermuda grass root exudates increased with decreasing molecular weight size fractions, while an opposite trend was observed at pH 6.5. Results from this study demonstrated the ability of Bermuda grass root exudates to complex lead in aqueous media.
C1 [Thomas, Catherine; Butler, Afrachanna; Larson, Steven; Medina, Victor] US Army Corps Engineers, Engineer Res & Dev Ctr, Environm Lab ERDC EL, Vicksburg, MS USA.
[Begonia, Maria] Jackson State Univ, Dept Biol, Jackson, MS USA.
RP Thomas, C (reprint author), Engineer Res & Dev Ctr, Environm Lab ERDC EL, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA.
EM catherine.c.thomas@usace.army.mil
NR 8
TC 0
Z9 0
U1 1
U2 71
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA
SN 1522-6514
EI 1549-7879
J9 INT J PHYTOREMEDIAT
JI Int. J. Phytoremediat.
PD JUN 3
PY 2014
VL 16
IS 6
BP 634
EP 640
DI 10.1080/15226514.2013.803023
PG 7
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA 236IB
UT WOS:000325787600008
PM 24912248
ER
PT J
AU Akhvlediani, T
Kurtskhalia, I
Mdivani, K
Ispireli, M
Meskhishvili, T
Nikolich, M
Bautista, C
Rivard, R
Garges, E
AF Akhvlediani, Tamar
Kurtskhalia, Irakli
Mdivani, Ketevan
Ispireli, Maya
Meskhishvili, Tinatin
Nikolich, Mikeljon
Bautista, Christian
Rivard, Robert
Garges, Eric
TI PREVALENCE OF SELECTED SEXUALLY TRANSMITTED INFECTIONS IN GEORGIA
MILITARY PERSONNEL
SO SEXUALLY TRANSMITTED DISEASES
LA English
DT Meeting Abstract
CT STD Prevention Conference
CY JUN 09-12, 2014
CL Atlanta, GA
C1 [Akhvlediani, Tamar] WRAIR USAMRIID Clin Res Unit, Tbilisi, Rep of Georgia.
[Kurtskhalia, Irakli; Mdivani, Ketevan; Ispireli, Maya; Meskhishvili, Tinatin] Minist Def Georgia, Mil Hosp, Gori, Rep of Georgia.
[Nikolich, Mikeljon; Bautista, Christian; Garges, Eric] Walter Reed Army Inst Res, Silver Spring, MD USA.
[Rivard, Robert] US Army, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA.
EM t_akhvlediani@yahoo.com
NR 0
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0148-5717
EI 1537-4521
J9 SEX TRANSM DIS
JI Sex. Transm. Dis.
PD JUN
PY 2014
VL 41
SU 1
MA WP 92
BP S120
EP S120
PG 1
WC Infectious Diseases
SC Infectious Diseases
GA CE7WB
UT WOS:000352051500425
ER
PT J
AU Garges, E
Jordan, N
Gaydos, J
AF Garges, Eric
Jordan, Nikki
Gaydos, Joel
TI THE CASE FOR CLASSIFYING THE US ARMY AS A VULNERABLE POPULATION
SO SEXUALLY TRANSMITTED DISEASES
LA English
DT Meeting Abstract
CT STD Prevention Conference
CY JUN 09-12, 2014
CL Atlanta, GA
C1 [Garges, Eric] US Army Publ Hlth Command, Silver Spring, MD USA.
[Jordan, Nikki] US Army Publ Hlth Command, Apg Ea, MD USA.
[Gaydos, Joel] Armed Forces Hlth Surveillance Ctr, Silver Spring, MD USA.
EM eric.c.garges.mil@mail.mil
NR 0
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0148-5717
EI 1537-4521
J9 SEX TRANSM DIS
JI Sex. Transm. Dis.
PD JUN
PY 2014
VL 41
SU 1
MA TP 100
BP S66
EP S66
PG 1
WC Infectious Diseases
SC Infectious Diseases
GA CE7WB
UT WOS:000352051500227
ER
PT J
AU Garges, E
Clark, L
Jordan, N
Leamer, N
Gaydos, J
AF Garges, Eric
Clark, Leslie
Jordan, Nikki
Leamer, Nicole
Gaydos, Joel
TI SYPHILIS AND THE US ARMY, NEW CONCERNS FOR AN OLD DISEASE
SO SEXUALLY TRANSMITTED DISEASES
LA English
DT Meeting Abstract
CT STD Prevention Conference
CY JUN 09-12, 2014
CL Atlanta, GA
C1 [Garges, Eric] US Army Publ Hlth Command, Silver Spring, MD USA.
[Clark, Leslie; Gaydos, Joel] Armed Forces Hlth Surveillance Ctr, Silver Spring, MD USA.
[Jordan, Nikki] US Army Publ Hlth Command, Apg Ea, MD USA.
[Leamer, Nicole] US Army Publ Hlth Command, Aberdeen Proving Ground, MD USA.
EM eric.c.garges.mil@mail.mil
NR 0
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0148-5717
EI 1537-4521
J9 SEX TRANSM DIS
JI Sex. Transm. Dis.
PD JUN
PY 2014
VL 41
SU 1
MA TP 101
BP S66
EP S67
PG 2
WC Infectious Diseases
SC Infectious Diseases
GA CE7WB
UT WOS:000352051500228
ER
PT J
AU Jordan, N
Clemmons, N
Nowak, G
Gaydos, J
AF Jordan, Nikki
Clemmons, Nakia
Nowak, Gosia
Gaydos, Joel
TI ESTIMATING THE BURDEN OF CHLAMYDIA TRACHOMATIS IN THE US ARMY - USE OF
THREE PASSIVE SURVEILLANCE SYSTEMS AND CAPTURE-RECAPTURE METHODS TO
IDENTIFY INCIDENT CASES
SO SEXUALLY TRANSMITTED DISEASES
LA English
DT Meeting Abstract
CT STD Prevention Conference
CY JUN 09-12, 2014
CL Atlanta, GA
C1 [Jordan, Nikki; Clemmons, Nakia] US Army Publ Hlth Command, APG EA, Gunpowder, MD USA.
[Nowak, Gosia] Navy & Marine Corps Publ Hlth Ctr, Portsmouth, Hants, England.
[Gaydos, Joel] Armed Forces Hlth Surveillance Ctr, Silver Spring, MD USA.
EM nikki.n.jordan.civ@mail.mil
NR 0
TC 0
Z9 0
U1 1
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0148-5717
EI 1537-4521
J9 SEX TRANSM DIS
JI Sex. Transm. Dis.
PD JUN
PY 2014
VL 41
SU 1
MA WP 122
BP S128
EP S128
PG 1
WC Infectious Diseases
SC Infectious Diseases
GA CE7WB
UT WOS:000352051500455
ER
PT J
AU Washburn, BE
Cisar, PJ
DeVault, TL
AF Washburn, Brian E.
Cisar, Paul J.
DeVault, Travis L.
TI Wildlife Strikes With Military Rotary-Wing Aircraft During Flight
Operations Within the United States
SO WILDLIFE SOCIETY BULLETIN
LA English
DT Article
DE airfields; helicopters; military; rotary-wing aircraft; wildlife strikes
ID COLLISIONS; AIRPORTS; RANKING; BIRDS; RISK
AB Wildlife-aircraft collisions (wildlife strikes) with civilian and military aircraft pose notable risks and economic losses. The 4 military services within the U. S. Department of Defense maintain records regarding wildlife strikes with military aircraft. Although rotary-wing aircraft operations comprise important mission components within all 4 military services, no assessment of wildlife strikes to military rotary-wing aircraft has been conducted. The objectives of this project were to 1) conduct a comprehensive analysis of data available from all military services regarding wildlife strikes with rotary-wing aircraft, and 2) provide recommendations to reduce the frequency and negative impacts of these strikes. We acquired all available wildlife strike records and parsed our database to include only wildlife strikes to military rotary-wing aircraft occurring within the contiguous United States, Alaska, Hawaii, or within near-shore areas along the coasts. We assessed the effects of year, month, time of day, event location (i.e., on-or off-airfield), and wildlife group involved on the frequency of wildlife strikes with rotary-wing aircraft. The frequency of wildlife strikes was highest during autumn (Sept-Nov; 41.6% of all strikes) and lowest during winter (Dec-Feb; 10.4%). Wildlife strikes occurred most often when aircraft were traveling en route (38.3%) or were engaged in terrain flight (28.9%). Raptors and vultures were commonly associated with wildlife strikes that caused damage to aircraft. Wildlife strikes to military rotary-wing aircraft during flight operations within the United States are both costly (averaging US$12,184-$337,281/strike event among the military services) and deadly (2 pilots were killed). Published 2014. This article is a U.S. Government work and is in the public domain in the USA.
C1 [Washburn, Brian E.; DeVault, Travis L.] Wildlife Serv, USDA, Anim Plant Hlth Inspect Serv, Natl Wildlife Res Ctr, Sandusky, OH 44870 USA.
[Cisar, Paul J.] US Army, Logist Div, Aberdeen Test Ctr, Aberdeen Proving Ground, MD 21005 USA.
RP Washburn, BE (reprint author), Wildlife Serv, USDA, Anim Plant Hlth Inspect Serv, Natl Wildlife Res Ctr, 6100 Columbus Ave, Sandusky, OH 44870 USA.
EM brian.e.washburn@aphis.usda.gov
FU United States Department of Defense (DoD) Legacy Resource Management
Program
FX We thank the United States Department of Defense (DoD) Legacy Resource
Management Program for funding and supporting the execution of this
project. We appreciate the encouragement, professional advice, and data
access provided by the U.S. Air Force Safety Center Bird-Wildlife
Aircraft Strike Hazard (BASH) Team (specifically D. Sullivan and Lt.
Tiffany Robertson), the U.S. Navy BASH Team and the Naval Safety Center
(specifically M. Klope and Lt. V. Jensen), the U.S. Army Combat
Readiness-Safety Center (specifically R. Dickinson and C. Lyle), and the
U.S. Coast Guard Safety Center (specifically Lieutenant Commander B.
Potter). B. Blackwell, M. Begier, and 2 anonymous reviewers provided
helpful comments that improved the manuscript. The content of this
manuscript reflects the views of the National Wildlife Research Center
and does not necessarily reflect the views of the DoD Legacy Resource
Management Program.
NR 29
TC 1
Z9 1
U1 2
U2 9
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1938-5463
J9 WILDLIFE SOC B
JI Wildl. Soc. Bull.
PD JUN
PY 2014
VL 38
IS 2
BP 311
EP 320
DI 10.1002/wsb.409
PG 10
WC Biodiversity Conservation
SC Biodiversity & Conservation
GA CD9PV
UT WOS:000351431200012
ER
PT J
AU Kamapantula, BK
Abdelzaher, A
Ghosh, P
Mayo, M
Perkins, EJ
Das, SK
AF Kamapantula, Bhanu K.
Abdelzaher, Ahmed
Ghosh, Preetam
Mayo, Michael
Perkins, Edward J.
Das, Sajal K.
TI Leveraging the robustness of genetic networks: a case study on
bio-inspired wireless sensor network topologies
SO JOURNAL OF AMBIENT INTELLIGENCE AND HUMANIZED COMPUTING
LA English
DT Article
DE Gene regulatory networks; Wireless sensor networks; NS-2; Robustness
ID COMPLEX NETWORKS; MOTIFS
AB Wireless sensor networks (WSNs) form a critical component in modern computing applications; given their size, ability to process and communicate information, and to sense stimuli, they are a promising part of the Internet of Things. However, they are also plagued by reliability and node failure problems. Here we address these problems by using the Gene Regulatory Networks (GRNs) of the organism Escherichia coli-believed to be robust against signaling disruptions, such as gene failures- to study the transmission properties of randomlygenerated WSNs and transmission structures derived from these genetic networks. Selection of sink nodes is crucial to the performance of these networks; here we introduce four sink-node selection techniques: two motif-based, an attractor based and a highest degree-based approach and perform comprehensive simulations to assess their performance. Specifically, we use NS-2 simulations to evaluate the packet transmission robustness properties of such GRN-derived communication structures as against typical randomly deployed sensor network topologies under varying channel loss models. Packet receipt rates are compared among these networks, which are shown to be higher using GRNs for the communication structure, rather than randomly generated WSNs. We also evaluate the performance of communication structures derived from existing biological network generation models to assess their applicability in providing robust communication. This work paves the way for future development of fault-tolerant and robust WSN deployment and routing algorithms based on the inherent signal transmission robustness properties of the gene regulatory network topologies.
C1 [Kamapantula, Bhanu K.; Abdelzaher, Ahmed; Ghosh, Preetam] Virginia Commonwealth Univ, Dept Comp Sci, Richmond, VA 23284 USA.
[Mayo, Michael; Perkins, Edward J.] US Army Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA.
[Das, Sajal K.] Univ Texas Arlington, Dept Comp Sci & Engn, Arlington, TX 76019 USA.
RP Kamapantula, BK (reprint author), Virginia Commonwealth Univ, Dept Comp Sci, Med Coll Virginia Campus, Richmond, VA 23284 USA.
EM kamapantulbk@mymail.vcu.edu; abdelzaheraf@mymail.vcu.edu;
pghosh@vcu.edu; Michael.L.Mayo@usace.army.mil;
Edward.J.Perkins@usace.army.mil; das@uta.edu
FU US Army's Environmental Quality and Installations 6.1 basic research
program; [NSF-1143737]
FX This work was supported by grant number NSF-1143737, and the US Army's
Environmental Quality and Installations 6.1 basic research program. The
Chief of Engineers approved this material for publication.
NR 28
TC 1
Z9 1
U1 0
U2 5
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1868-5137
EI 1868-5145
J9 J AMB INTEL HUM COMP
JI J. Ambient Intell. Humaniz. Comput.
PD JUN
PY 2014
VL 5
IS 3
SI SI
BP 323
EP 339
DI 10.1007/s12652-013-0180-0
PG 17
WC Computer Science, Artificial Intelligence; Computer Science, Information
Systems; Telecommunications
SC Computer Science; Telecommunications
GA CD6ZL
UT WOS:000351239900006
ER
PT J
AU Crete, JE
Jones, J
Neumeier, R
AF Crete, Joan E.
Jones, Jenny
Neumeier, Robin
TI Perplexing Presentation of Pink Breast Milk
SO JOGNN-JOURNAL OF OBSTETRIC GYNECOLOGIC AND NEONATAL NURSING
LA English
DT Meeting Abstract
DE postpartum; breastfeeding; infection; Serratia marcescens
C1 [Crete, Joan E.; Jones, Jenny; Neumeier, Robin] Tripler Army Med Ctr, Honolulu, HI 96859 USA.
NR 0
TC 0
Z9 0
U1 0
U2 3
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0884-2175
EI 1552-6909
J9 JOGNN-J OBST GYN NEO
JI JOGNN
PD JUN
PY 2014
VL 43
SU 1
SI SI
BP S86
EP S86
DI 10.1111/1552-6909.12322
PG 1
WC Nursing; Obstetrics & Gynecology
SC Nursing; Obstetrics & Gynecology
GA CB9NR
UT WOS:000349959000119
ER
PT J
AU Greene, WA
Muniz, A
Plamper, ML
Kaini, RR
Wang, HC
AF Greene, Whitney A.
Muniz, Alberto
Plamper, Mark L.
Kaini, Ramesh R.
Wang, Heuy-Ching
TI MicroRNA Expression Profiles of Human iPS Cells, Retinal Pigment
Epithelium Derived From iPS, and Fetal Retinal Pigment Epithelium
SO JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
LA English
DT Article
DE Molecular Biology; Issue 88; microRNA; microarray; human
induced-pluripotent stem cells; retinal pigmented epithelium
ID PLURIPOTENT STEM-CELLS; RPE; DIFFERENTIATION; TRANSPLANTATION; SECRETION
AB The objective of this report is to describe the protocols for comparing the microRNA (miRNA) profiles of human induced-pluripotent stem (iPS) cells, retinal pigment epithelium (RPE) derived from human iPS cells (iPS-RPE), and fetal RPE. The protocols include collection of RNA for analysis by microarray, and the analysis of microarray data to identify miRNAs that are differentially expressed among three cell types. The methods for culture of iPS cells and fetal RPE are explained. The protocol used for differentiation of RPE from human iPS is also described. The RNA extraction technique we describe was selected to allow maximal recovery of very small RNA for use in a miRNA microarray. Finally, cellular pathway and network analysis of microarray data is explained. These techniques will facilitate the comparison of the miRNA profiles of three different cell types.
C1 [Greene, Whitney A.; Muniz, Alberto; Plamper, Mark L.; Kaini, Ramesh R.; Wang, Heuy-Ching] US Army Inst Surg Res, Jbsa Ft Sam Houston, TX 78234 USA.
RP Wang, HC (reprint author), US Army Inst Surg Res, Jbsa Ft Sam Houston, TX 78234 USA.
EM heuy-ching.h.wang.civ@mail.mil
FU U.S. Army Clinical Rehabilitative Medicine Research Program (CRMRP);
Military Operational Medicine Research Program (MOMRP)
FX This work was supported by U.S. Army Clinical Rehabilitative Medicine
Research Program (CRMRP) and Military Operational Medicine Research
Program (MOMRP).
NR 30
TC 0
Z9 0
U1 0
U2 2
PU JOURNAL OF VISUALIZED EXPERIMENTS
PI CAMBRIDGE
PA 1 ALEWIFE CENTER, STE 200, CAMBRIDGE, MA 02140 USA
SN 1940-087X
J9 JOVE-J VIS EXP
JI J. Vis. Exp.
PD JUN
PY 2014
IS 88
AR e51589
DI 10.3791/51589
PG 8
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA CB0BQ
UT WOS:000349290100046
PM 24999033
ER
PT J
AU Mitrano, DM
Ranville, JF
Bednar, A
Kazor, K
Hering, AS
Higgins, CP
AF Mitrano, D. M.
Ranville, J. F.
Bednar, A.
Kazor, K.
Hering, A. S.
Higgins, C. P.
TI Tracking dissolution of silver nanoparticles at environmentally relevant
concentrations in laboratory, natural, and processed waters using single
particle ICP-MS (spICP-MS)
SO ENVIRONMENTAL SCIENCE-NANO
LA English
DT Article
ID PLASMA-MASS SPECTROMETRY; ION-RELEASE KINETICS; ENGINEERED
NANOPARTICLES; AGGREGATION KINETICS; NANOSILVER; TOXICITY; EXPOSURE;
FATE; NANOMATERIALS; SIZE
AB The interplay between engineered nanoparticle (ENP) size, surface area, and dissolution rate is critical in predicting ENP environmental behavior. Single particle inductively coupled plasma mass spectrometry (spICP-MS) enables the study of ENPs at dilute (ng L-1) concentrations, facilitating the measurement of ENP behavior in natural systems. Here, the utility of using spICP-MS to quantitatively track the changes in particle diameter over time for 60 and 100 nm Ag ENPs (citrate, tannic acid, and polyvinylpyrrolidone coated) was demonstrated. Short term (<24 h) and intermediate term (1 week) dissolution was examined, with rates for all particles slowing by over an order of magnitude after approximately 24 h. Dissolution was measured primarily as a decrease in particle diameter over time but direct measurement of Ag-(aq)(+) was also completed for the experiments. The importance of water chemistry including chloride, sulfide, and dissolved organic carbon (DOC) was demonstrated, with higher concentrations (1 mg L-1 Cl-, S2- and 20 mg L-1 DOC) resulting in negligible Ag ENP dissolution over 24 h. Slight decreases in particle diameter (<10%) were observed with lower concentrations of these parameters (stoichiometric Cl-, S2- and 2 mg L-1 DOC). Capping agents showed variable effects on dissolution. ENP behavior was also investigated in natural (moderately hard water, creek water) and tap water. Water chemistry was the most significant factor affecting dissolution. Near complete dissolution was observed in chlorinated tap water within several hours. Though modeled as first-order kinetic transformations, the dissolution rates observed suggested the dissolution kinetics might be significantly more complex. Two specific highlights of the benefits of using the spICP-MS technique to measure dissolution in complex samples include 1) the measurement of primary particle size as the metric of dissolution is more direct than attempting to measure the increase of Ag+ in solution and 2) that this is possible even when known sinks for Ag+ exist in the system (e.g. DOC, sediments, biota, sampling container).
C1 [Mitrano, D. M.; Ranville, J. F.] Colorado Sch Mines, Dept Chem & Geochem, Golden, CO 80401 USA.
[Mitrano, D. M.] Empa Mat Sci & Technol, Technol & Soc Lab, St Gallen, Switzerland.
[Bednar, A.] US Army, Engineer Res & Dev Ctr, Vicksburg, MS USA.
[Kazor, K.; Hering, A. S.] Colorado Sch Mines, Dept Appl Math & Stat, Golden, CO 80401 USA.
[Higgins, C. P.] Colorado Sch Mines, Dept Civil & Environm Engn, Golden, CO 80401 USA.
RP Higgins, CP (reprint author), Colorado Sch Mines, Dept Civil & Environm Engn, Golden, CO 80401 USA.
EM chiggins@mines.edu
RI Higgins, Christopher/B-1836-2010
OI Higgins, Christopher/0000-0001-6220-8673
FU U.S. Army Corps of Engineers [W912HZ-09-P-0163]
FX The authors thank the U.S. Army Corps of Engineers (W912HZ-09-P-0163)
for funding. Dr. Bernd Nowack and three anonymous reviewers provided
valuable comments during manuscript review.
NR 59
TC 48
Z9 49
U1 23
U2 106
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
ENGLAND
SN 2051-8153
EI 2051-8161
J9 ENVIRON-SCI NANO
JI Environ.-Sci. Nano
PD JUN
PY 2014
VL 1
IS 3
BP 248
EP 259
DI 10.1039/c3en00108c
PG 12
WC Chemistry, Multidisciplinary; Environmental Sciences; Nanoscience &
Nanotechnology
SC Chemistry; Environmental Sciences & Ecology; Science & Technology -
Other Topics
GA AZ1AL
UT WOS:000347972700005
ER
PT J
AU Penn-Barwell, JG
Rand, BCC
Brown, KV
Wenke, JC
AF Penn-Barwell, J. G.
Rand, B. C. C.
Brown, K. V.
Wenke, J. C.
TI A versatile model of open-fracture infection A CONTAMINATED SEGMENTAL
RAT FEMUR DEFECT
SO BONE & JOINT RESEARCH
LA English
DT Article
DE Infection; Open fracture; Contamination; Animal-model; Local antibiotics
ID OPEN TIBIAL FRACTURES; REDUCE INFECTION; LONG-TERM; WOUNDS; TRAUMA
AB Objectives
The purpose of this study was to refine an accepted contaminated rat femur defect model to result in an infection rate of approximately 50%. This threshold will allow examination of treatments aimed at reducing infection in open fractures with less risk of type II error.
Methods
Defects were created in the stablised femurs of anaethetised rats, contaminated with Staphylococcus aureus and then debrided and irrigated six hours later. After 14 days, the bone and implants were harvested for separate microbiological analysis. This basic model was developed in several studies by varying the quantity of bacterial inoculation, introducing various doses of systemic antibiotics with and without local antibiotics.
Results
The bacterial inoculation associated with a 50% infection rate was established as 1 x 10(2) colony forming units (CFU). With an initial bacterial inoculum of 1 x 10(5) CFU, the dose of systemic antibiotics associated with 50% infection was 5 mg/Kg of cafazolin injected sub-cutaneously every 12 hours, starting at the time of the first debridment and continuing for 72 hours (seven doses). The systemic dose of cafazolin was lowered to 2 mg/Kg when antibiotic polymethyl methacrylate beads were used concurrently with the same amount of bacterial inoculation.
Conclusion
This model of open fracture infection has been further refined with potential for local and systemic antibiotics. This is a versatile model and with the concepts presented herein, it can be modified to evaluate various emerging therapies and concepts for open fractures.
C1 US Army Inst Surg Res, Houston, TX USA.
Royal Ctr Def Med, London, England.
RP Penn-Barwell, JG (reprint author), Royal Ctr Def Med, Acad Dept Mil Surg & Trauma, Trauma & Orthopaed Registrar British Army, Birmingham, W Midlands, England.
EM jowan@doctors.net.uk
OI rand, ben/0000-0002-9938-2082
NR 15
TC 7
Z9 8
U1 0
U2 3
PU BRITISH EDITORIAL SOC BONE JOINT SURGERY
PI LONDON
PA 22 BUCKINGHAM STREET, LONDON WC2N 6ET, ENGLAND
SN 2046-3758
J9 BONE JOINT RES
JI Bone Jt. Res.
PD JUN
PY 2014
VL 3
IS 6
BP 187
EP 192
DI 10.1302/2046-3758.36.2000293
PG 6
WC Cell & Tissue Engineering; Orthopedics
SC Cell Biology; Orthopedics
GA AT2KM
UT WOS:000344763600003
PM 24926038
ER
PT J
AU Excler, JL
Robb, ML
Kim, JH
AF Excler, Jean-Louis
Robb, Merlin L.
Kim, Jerome H.
TI HIV-1 vaccines Challenges and new perspectives
SO HUMAN VACCINES & IMMUNOTHERAPEUTICS
LA English
DT Review
DE HIV-1; vaccine; correlates; clinical trial; efficacy; public health;
licensure
ID T-CELL RESPONSES; RECOMBINANT GLYCOPROTEIN-120 VACCINE; NEUTRALIZING
ANTIBODY-RESPONSE; HIGHLY PATHOGENIC SIV; ADENOVIRUS SEROTYPE 5;
RHESUS-MONKEYS; EFFICACY TRIAL; IMMUNE-RESPONSES; BOOST VACCINE;
OF-CONCEPT
AB The development of a safe and effective preventive HIV-1 vaccine remains a public health priority. Despite scientific difficulties and disappointing results, HIV-1 vaccine clinical development has, for the first time, established proof-of-concept efficacy against HIV-1 acquisition and identified vaccine-associated immune correlates of risk. The correlate of risk analysis showed that IgG antibodies against the gp120 V2 loop correlated with decreased risk of HIV infection, while Env-specific IgA directly correlated with increased risk. The development of vaccine strategies such as improved envelope proteins formulated with potent adjuvants and DNA and vectors expressing mosaics, or conserved sequences, capable of eliciting greater breadth and depth of potentially relevant immune responses including neutralizing and non-neutralizing antibodies, CD4+ and CD8+ cell-mediated immune responses, mucosal immune responses, and immunological memory, is now proceeding quickly. Additional human efficacy trials combined with other prevention modalities along with sustained funding and international collaboration remain key to bring an HIV-1 vaccine to licensure.
C1 [Excler, Jean-Louis; Robb, Merlin L.; Kim, Jerome H.] Walter Reed Army Inst Res, Div Retrovirol, US Mil HIV Res Program, Bethesda, MD 20814 USA.
[Excler, Jean-Louis; Robb, Merlin L.] Henry M Jackson Fdn Adv Mil Med, Bethesda, MD USA.
RP Excler, JL (reprint author), Walter Reed Army Inst Res, Div Retrovirol, US Mil HIV Res Program, Bethesda, MD 20814 USA.
EM jexcler@hivresearch.org
FU US Army Medical Research and Materiel Command (USA MRMC)
[Y1-AI-2642-12]; National Institutes of Allergy and Infectious Diseases
[Y1-AI-2642-12]; Henry M. Jackson Foundation for the Advancement of
Military Medicine, Inc. [W81XWH-07-2-0067]; US Department of Defense
(DOD) [W81XWH-07-2-0067]
FX The preparation of this manuscript was supported in part by an
Interagency Agreement Y1-AI-2642-12 between the US Army Medical Research
and Materiel Command (USA MRMC) and the National Institutes of Allergy
and Infectious Diseases. In addition this work was supported by a
cooperative agreement (W81XWH-07-2-0067) between the Henry M. Jackson
Foundation for the Advancement of Military Medicine, Inc., and the US
Department of Defense (DOD). We are grateful to Stephanie Stevens, U.S.
Military HIV Research Program, for helping designing the Figure.
NR 148
TC 12
Z9 12
U1 2
U2 11
PU LANDES BIOSCIENCE
PI AUSTIN
PA 1806 RIO GRANDE ST, AUSTIN, TX 78702 USA
SN 2164-5515
EI 2164-554X
J9 HUM VACC IMMUNOTHER
JI Human Vaccines Immunother.
PD JUN
PY 2014
VL 10
IS 6
BP 1734
EP 1746
DI 10.4161/hv.28462
PG 13
WC Biotechnology & Applied Microbiology; Immunology
SC Biotechnology & Applied Microbiology; Immunology
GA AQ4JV
UT WOS:000342763200044
PM 24637946
ER
PT J
AU Burch, HB
Burman, KD
Cooper, DS
Hennessey, JV
AF Burch, Henry B.
Burman, Kenneth D.
Cooper, David S.
Hennessey, James V.
TI A 2013 Survey of Clinical Practice Patterns in the Management of Primary
Hypothyroidism
SO JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
LA English
DT Article
ID AMERICAN THYROID ASSOCIATION; THYROTROPIN LEVELS; SUBCLINICAL
HYPOTHYROIDISM; PRACTICE GUIDELINE; SERUM THYROTROPIN; DOUBLE-BLIND;
PREGNANCY; DISEASE; LEVOTHYROXINE; THERAPY
AB Context: In 2012, comprehensive clinical practice guidelines (CPGs) were published regarding the management of hypothyroidism.
Objective: We sought to document current practices in the management of primary hypothyroidism and compare these results with recommendations made in the 2012 American Thyroid Association (ATA)/American Association of Clinical Endocrinologists (AACE) hypothyroidism CPGs. In addition, we sought to examine differences in management among international members of U.S.-based endocrine societies and to compare survey results with those obtained from a survey of ATA members performed 12 years earlier.
Methods: Clinical members of The Endocrine Society (TES), the ATA, and the AACE were asked to take a web-based survey consisting of 30 questions dealing with testing, treatment, and modulating factors in the management of primary hypothyroidism.
Results: In total, 880 respondents completed the survey, including 618 members of TES, 582 AACE members, and 208 ATA members. North American respondents accounted for 67.6%, Latin American 9.7%, European 9.2%, Asia and Oceania 8.1%, and Africa and Middle East 5.5%. Overt hypothyroidism would be treated using L-T-4 alone by 99.2% of respondents; 0.8% would use combination L-T-4 and liothyronine (L-T-3) therapy. Generic L-T-4 would be used by 49.3% and a brand name by 49.9%. The rate of replacement would be gradual (38.5%); an empiric dose, adjusted to achieve target (33.6%); or a calculated full replacement dose (27.8%). A target TSH of 1.0 to 1.9 mU/L was favored in the index case, but 3.0 to 3.9 mU/L was the most commonly selected TSH target for an octogenarian. Persistent hypothyroid symptoms despite achieving a target TSH would prompt testing for other causes by 84.3% of respondents, a referral to primary care by 11.3%, and a change to L-T-4 plus L-T-3 therapy by 3.6%. Evaluation of persistent symptoms would include measurement of T-3 levels by 21.9% of respondents. Subclinical disease with a TSH 5.0 to 10.0 mU/L would be treated without further justification by 21.3% of respondents, or in the presence of positive thyroid peroxidase antibodies (62.3%), hypothyroid symptoms (60.9%), high low-density lipoprotein (52.9%), or goiter (46.6%). The TSH target for a newly pregnant patient was <2.5 mU/L for 96.1% of respondents, with 63.5% preferring a TSH target <1.5 mU/L. Thyroid hormone levels would be checked every 4 weeks during pregnancy by 67.7% and every 8 weeks by an additional 21.4%. A hypothyroid patient with TSH of 0.5 mU/L who becomes pregnant would receive an immediate L-T-4 dose increase by only 36.9% of respondents.
Conclusion: The current survey of clinical endocrinologists catalogs current practice patterns in the management of hypothyroidism and demonstrates 1) a nearly exclusive preference for L-T-4 alone as initial therapy, 2) the widespread use of age-specific TSH targets for replacement therapy, 3) a low threshold for treating mild thyroid failure, 4) meticulous attention to TSH targets in the pregnant and prepregnant woman, and 5) a highly variable approach to both the rate and means of restoring euthyroidism for overt disease. Both alignment and focal divergence from recent CPGs are demonstrated.
C1 [Burch, Henry B.] Walter Reed Natl Mil Med Ctr, Div Endocrinol, Bethesda, MD 20889 USA.
[Burman, Kenneth D.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA.
[Burman, Kenneth D.] Washington Hosp Ctr, Endocrinol Sect, Washington, DC 20010 USA.
[Burman, Kenneth D.] Georgetown Univ, Med Ctr, Washington, DC 20007 USA.
[Cooper, David S.] Johns Hopkins Univ, Sch Med, Div Endocrinol, Baltimore, MD 21205 USA.
[Hennessey, James V.] Beth Israel Deaconess Med Ctr, Div Endocrinol, Boston, MA 02215 USA.
[Hennessey, James V.] Harvard Univ, Sch Med, Boston, MA 02115 USA.
RP Burch, HB (reprint author), US Army, Walter Reed Natl Mil Med Ctr, Div Endocrinol, 8901 Wisconsin Ave,Bldg 19,Room 5053, Bethesda, MD 20889 USA.
EM henry.b.burch.mil@health.mil
NR 31
TC 11
Z9 11
U1 0
U2 4
PU ENDOCRINE SOC
PI WASHINGTON
PA 2055 L ST NW, SUITE 600, WASHINGTON, DC 20036 USA
SN 0021-972X
EI 1945-7197
J9 J CLIN ENDOCR METAB
JI J. Clin. Endocrinol. Metab.
PD JUN
PY 2014
VL 99
IS 6
BP 2077
EP 2085
DI 10.1210/jc.2014-1046
PG 9
WC Endocrinology & Metabolism
SC Endocrinology & Metabolism
GA AP8PI
UT WOS:000342340500049
PM 24527720
ER
PT J
AU Myers, MA
AF Myers, Mary Anne
TI Unsexing Petrarch: Charlotte Smith's Lessons in the Sonnet as a Social
Medium
SO STUDIES IN ROMANTICISM
LA English
DT Article
ID SMITH,CHARLOTTE; 'ELEGIAC-SONNETS'
C1 US Mil Acad, West Point, NY 10996 USA.
RP Myers, MA (reprint author), US Mil Acad, West Point, NY 10996 USA.
NR 50
TC 0
Z9 0
U1 0
U2 0
PU BOSTON UNIV SCHOLARLY PUBL
PI BOSTON
PA 985 COMMONWEALTH AVE, BOSTON, MA 02215 USA
SN 0039-3762
J9 STUD ROMANTICISM
JI Stud. Romant.
PD SUM
PY 2014
VL 53
IS 2
BP 239
EP 263
PG 25
WC Literature
SC Literature
GA AQ1JO
UT WOS:000342537900005
ER
PT J
AU Conti, G
Shay, L
Hartzog, W
AF Conti, Gregory
Shay, Lisa
Hartzog, Woodrow
TI Deconstructing the Relationship Between Privacy and Security
SO IEEE TECHNOLOGY AND SOCIETY MAGAZINE
LA English
DT Editorial Material
C1 [Conti, Gregory; Shay, Lisa] US Mil Acad, Dept Elect Engn & Comp Sci, West Point, NY 10996 USA.
[Conti, Gregory] West Points Cyber Res Ctr, West Point, NY USA.
[Hartzog, Woodrow] Samford Univ, Cumberland Sch Law, Birmingham, AL USA.
[Hartzog, Woodrow] Stanford Law Sch, Ctr Internet & Soc, Stanford, CA USA.
RP Conti, G (reprint author), US Mil Acad, Dept Elect Engn & Comp Sci, West Point, NY 10996 USA.
EM gregory.conti@usma.edu; lisa.shay@usma.edu; whartzog@samford.edu
NR 9
TC 0
Z9 0
U1 0
U2 2
PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
PI PISCATAWAY
PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA
SN 0278-0097
EI 1937-416X
J9 IEEE TECHNOL SOC MAG
JI IEEE Technol. Soc. Mag.
PD SUM
PY 2014
VL 33
IS 2
BP 28
EP 30
DI 10.1109/MTS.2014.2319897
PG 3
WC Engineering, Electrical & Electronic
SC Engineering
GA AP9KL
UT WOS:000342398600010
ER
PT J
AU Watson, S
AF Watson, Samuel
TI Frontier Cavalry Trooper: The Letters of Private Eddie Matthews,
1869-1874
SO NEW MEXICO HISTORICAL REVIEW
LA English
DT Book Review
C1 [Watson, Samuel] US Mil Acad, West Point, NY 10996 USA.
RP Watson, S (reprint author), US Mil Acad, West Point, NY 10996 USA.
NR 1
TC 0
Z9 0
U1 0
U2 0
PU UNIV NEW MEXICO
PI ALBUQUERQUE
PA NEW MEXICO HISTORICAL REVIEW, 1013 MESA VISTA HALL, ALBUQUERQUE, NM
87131-1186 USA
SN 0028-6206
J9 NEW MEX HIST REV
JI N. M. Hist. Rev.
PD SUM
PY 2014
VL 89
IS 3
BP 418
EP 419
PG 2
WC History
SC History
GA AQ2JQ
UT WOS:000342612000015
ER
PT J
AU Bell, JR
AF Bell, Jocelyn R.
TI THE UNIFORM BOX PRODUCT
SO PROCEEDINGS OF THE AMERICAN MATHEMATICAL SOCIETY
LA English
DT Article
AB The uniform box product problem is a weakening of the well-known box product problem, which asks whether box products of certain compact spaces are normal or even paracompact. Using uniformities, a new topology on products is defined between the box and Tychonov topologies. This new product, called the uniform box product, is an extension of the sup metric to powers of compact spaces. We investigate a certain non-metrizable compact space whose uniform box product, in ZFC, is normal, countably paracompact, and collectionwise Hausdorff.
C1 US Mil Acad, Dept Math Sci, West Point, NY 10996 USA.
RP Bell, JR (reprint author), US Mil Acad, Dept Math Sci, West Point, NY 10996 USA.
EM bell.jocelyn@gmail.com
NR 9
TC 2
Z9 2
U1 0
U2 0
PU AMER MATHEMATICAL SOC
PI PROVIDENCE
PA 201 CHARLES ST, PROVIDENCE, RI 02940-2213 USA
SN 0002-9939
EI 1088-6826
J9 P AM MATH SOC
JI Proc. Amer. Math. Soc.
PD JUN
PY 2014
VL 142
IS 6
BP 2161
EP 2171
AR PII S0002-9939(2014)11910-1
PG 11
WC Mathematics, Applied; Mathematics
SC Mathematics
GA AP7YJ
UT WOS:000342294200030
ER
PT J
AU Whitby, MD
Carter, TC
Britzke, ER
Bergeson, SM
AF Whitby, Michael D.
Carter, Timothy C.
Britzke, Eric R.
Bergeson, Scott M.
TI Evaluation of mobile acoustic techniques for bat population monitoring
SO ACTA CHIROPTEROLOGICA
LA English
DT Article
DE active sampling; Anabat; bats; mobile acoustic monitoring; passive
sampling; population monitoring; sampling methods
ID INSECTIVOROUS BATS; ECHOLOCATION CALLS; UNITED-STATES; HABITAT;
COMMUNITIES; DETECTORS; PATTERNS; DESIGN
AB Understanding population trends of any species is essential for conservation and management. However, due to difficulty in sampling some species, population status of many bat species is poorly understood. In an effort to resolve this issue, especially in light of emerging threats (e.g., white-nose syndrome and wind energy), a national mobile acoustic monitoring protocol, modeled after European programs, was developed to survey summer bat populations in the United States. While the program calls for conducting transects along roadways, some have suggested that waterways may allow for the gathering of more information. Therefore, we quantified species richness and abundance along car and boat transects to identify the most efficient mobile method. Furthermore, to compare the capabilities of mobile acoustic transects to a more traditional and better understood survey method, we compared species density along transects to stationary acoustic detectors. Using sample-based rarefaction, there was no difference at the 95% confidence level in species density (species/sample) between methods, however stationary points accumulated species more quickly than mobile methods. Of the mobile transect methods, car transects had higher diversity indices than boat transects and tended to show slightly higher species density. While over 1.5 times as many calls were recorded and identified along boat transects, there were no clear advantages of boat transects for monitoring bats except for Myotis grisescens. Additionally, car transects were least time consuming, leading us to conclude that car transects are the most efficient mobile acoustic method to monitor species. Mobile acoustic transects can likely monitor 2-4 species in the Eastern United States, including species with no current population monitoring methodology.
C1 [Whitby, Michael D.; Carter, Timothy C.; Bergeson, Scott M.] Ball State Univ, Dept Biol, Muncie, IN 47303 USA.
[Britzke, Eric R.] US Army, Engn Res & Dev Ctr, Vicksburg, MS 39180 USA.
RP Whitby, MD (reprint author), Ball State Univ, Dept Biol, Muncie, IN 47303 USA.
EM Michael.Whitby@gmail.com
FU Shawnee National Forest; Bat Conservation International
FX A special thanks the many field technicians who assisted with the
project. Funding was provided by Shawnee National Forest and Bat
Conservation International. Comments from two anonymous reviewers
greatly improved the manuscript.
NR 39
TC 3
Z9 4
U1 11
U2 87
PU MUSEUM & INST ZOOLOGY PAS-POLISH ACAD SCIENCES
PI WARSAW
PA WILCZA STREET 64, 00-679 WARSAW, POLAND
SN 1508-1109
EI 1733-5329
J9 ACTA CHIROPTEROL
JI Acta Chiropt.
PD JUN
PY 2014
VL 16
IS 1
BP 223
EP 230
DI 10.3161/150811014X683417
PG 8
WC Zoology
SC Zoology
GA AN8LF
UT WOS:000340855000020
ER
PT J
AU Gallaway, MS
Lagana-Riordan, C
Fink, DS
Pecko, JA
Barczyk, AN
Brannen, SJ
Milliken, AM
AF Gallaway, M. Shayne
Lagana-Riordan, Christine
Fink, David S.
Pecko, Joseph A.
Barczyk, Amanda N.
Brannen, Stephen J.
Milliken, Amy M.
TI An Epidemiological Assessment of Reintegration and Behavioral Health
Risk at Joint Base Lewis-McCord, Washington
SO MILITARY MEDICINE
LA English
DT Article
ID MENTAL-HEALTH; POSTTRAUMATIC GROWTH; SUBSTANCE-ABUSE; ARMY SOLDIERS;
STIGMA; SUICIDE; CARE; ASSOCIATION; PREVENTION; SYMPTOMS
AB Soldiers from a brigade at Joint Base Lewis-McChord, Washington, were alleged to have committed numerous crimes, including murder of civilians, during a recent deployment. This study was done to assist the command with (1) analyzing the climate and challenges facing redeploying Soldiers; (2) assessing behavioral risk at both individual and unit levels through targeted reintegration screening; and (3) recommending mitigating strategies to enhance current reintegration processes and reduce the level of high-risk behavior among Soldiers following deployment. The findings from this public health investigation suggest levels of risk and major areas of concern during the redeployment period varied across battalions within the brigade and that risk stratification postdeployment was not correlated with discernible differences in predeployment indicators. Acts of violence were limited to the deployment and immediate postdeployment periods and were allegedly perpetrated by a very small number of Soldiers.
C1 [Gallaway, M. Shayne; Lagana-Riordan, Christine; Fink, David S.; Pecko, Joseph A.; Barczyk, Amanda N.; Brannen, Stephen J.; Milliken, Amy M.] US Army, Inst Publ Hlth, Behav & Social Hlth Outcomes Program, Gunpowder, MD 21010 USA.
RP Gallaway, MS (reprint author), US Army, Inst Publ Hlth, Behav & Social Hlth Outcomes Program, 5158 Blackhawk Rd,Bldg E-1570, Gunpowder, MD 21010 USA.
NR 35
TC 0
Z9 0
U1 1
U2 1
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
EI 1930-613X
J9 MIL MED
JI Milit. Med.
PD JUN
PY 2014
VL 179
IS 6
BP 594
EP 601
DI 10.7205/MILMED-D-13-00340
PG 8
WC Medicine, General & Internal
SC General & Internal Medicine
GA AN7UM
UT WOS:000340806500002
PM 24902124
ER
PT J
AU Galvagno, SM
Dubose, JJ
Grissom, TE
Fang, R
Smith, R
Bebarta, VS
Shackelford, S
Scalea, TM
AF Galvagno, Samuel M.
Dubose, Joseph J.
Grissom, Thomas E.
Fang, Raymond
Smith, Richard
Bebarta, Vikhyat S.
Shackelford, Stacy
Scalea, Thomas M.
TI The Epidemiology of Critical Care Air Transport Team Operations in
Contemporary Warfare
SO MILITARY MEDICINE
LA English
DT Article
ID SEVERE LUNG INJURY; RESCUE TEAM; MILITARY; FORCE; US
AB Critical Care Air Transport Teams (CCATTs) have evolved as a vital component of the U.S. Air Force's aeromedical evacuation system. Previous epidemiological research in this area is limited. The objective of this commentary is to highlight the importance of obtaining robust epidemiological data regarding patients transported by CCATTs. A limited epidemiological analysis was performed to describe CCATT patients transported during Operation Enduring Freedom and the waning months of Operation Iraqi Freedom. CCATT transports for the calendar year 2011 were examined as recorded in the U.S. Transportation Command Regulating and Command and Control (C2) Evacuation System database. As many as 290 CCATT primary patient transport records were reviewed. Of these, 58.6% of patients had multiple injuries, 15.9% of patients had traumatic brain injury, 7% had acute coronary syndromes, and 24.8% of all transports were for nonbattle-related injuries. The most common International Classification of Disease, 9th Edition, Clinical Modification coded injury was bilateral lower extremity amputation (40%). Explosive blasts were the top mechanism of injury for patients requiring CCAT. The distribution of injuries and illnesses requiring CCAT appear to have changed compared to previous conventional conflicts. Understanding the epidemiology of casualties evacuated by CCATT during modern warfare is a prerequisite for the development of effective predeployment training to ensure optimal outcomes for critically ill and injured warriors.
C1 [Galvagno, Samuel M.; Grissom, Thomas E.] Univ Maryland, Sch Med, Ctr Shock Trauma, Dept Anesthesiol,Div Trauma Anesthesiol,Program T, Baltimore, MD 21201 USA.
[Galvagno, Samuel M.; Grissom, Thomas E.] Univ Maryland, Sch Med, Ctr Shock Trauma, Dept Anesthesiol,Div Crit Care Med,Program Trauma, Baltimore, MD 21201 USA.
[Dubose, Joseph J.; Shackelford, Stacy] Univ Maryland, Sch Med, Ctr Shock Trauma, Program Trauma, Baltimore, MD 21201 USA.
[Dubose, Joseph J.; Fang, Raymond; Shackelford, Stacy] US Air Force, CSTARS, Baltimore, MD 21201 USA.
[Smith, Richard] Air Univ, Maxwell Air Force Base, Montgomery, AL 36112 USA.
[Bebarta, Vikhyat S.] US Army, Inst Surg Res, Route Care Res Ctr, Ft Sam Houston, TX 78234 USA.
RP Galvagno, SM (reprint author), Univ Maryland, Sch Med, Ctr Shock Trauma, Dept Anesthesiol,Div Trauma Anesthesiol,Program T, T1R83,22 South Greene St, Baltimore, MD 21201 USA.
RI bebarta, vikhyat/K-3476-2015
NR 21
TC 3
Z9 3
U1 0
U2 3
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
EI 1930-613X
J9 MIL MED
JI Milit. Med.
PD JUN
PY 2014
VL 179
IS 6
BP 612
EP 618
DI 10.7205/MlLMED-D-13-00474
PG 7
WC Medicine, General & Internal
SC General & Internal Medicine
GA AN7UM
UT WOS:000340806500005
PM 24902127
ER
PT J
AU Maruta, J
Heaton, KJ
Mau, AL
Ghajar, J
AF Maruta, Jun
Heaton, Kristin J.
Mau, Alexis L.
Ghajar, Jamshid
TI Predictive Visual Tracking: Specificity in Mild Traumatic Brain Injury
and Sleep Deprivation
SO MILITARY MEDICINE
LA English
DT Article
ID PURSUIT EYE-MOVEMENTS; SMOOTH-PURSUIT; ATTENTION; SYNCHRONIZATION
AB We tested whether reduced cognitive function associated with mild traumatic brain injury (mTBI) and sleep deprivation can be detected and distinguished using indices of predictive visual tracking. A circular visual tracking test was given to 13 patients with acute mTBI (recruited within 2 weeks of injury), 127 normal control subjects, and 43 healthy subjects who were fatigued by 26-hour sleep deprivation. Eye movement was monitored with video-oculography. In the mTBI-related portion of the study, visual tracking performance of acute mTBI patients was significantly worse than normal subjects (p < 0.001). In the sleep-deprivation-related portion of the study, no change was detected between the two baseline measures separated by 2 to 3 weeks, but the 26-hour sleep deprivation significantly degraded the visual tracking performance (p < 0.001). The mTBI subjects had substantially worse visual tracking than sleep-deprived subjects that could also be identified with different visual tracking indices, indicating possible different neurophysiological mechanisms. Results suggest that cognitive, impairment associated with mTBI and fatigue may be triaged with the aid of visual tracking measures.
C1 [Maruta, Jun; Ghajar, Jamshid] Brain Trauma Fdn, World Trade Ctr 7, New York, NY 10007 USA.
[Heaton, Kristin J.; Mau, Alexis L.] US Army, Inst Environm Med, Mil Performance Div, Natick, MA 01760 USA.
[Heaton, Kristin J.; Mau, Alexis L.] Boston Univ, Sch Publ Hlth, Dept Environm Hlth, Boston, MA 02118 USA.
[Ghajar, Jamshid] Stanford Univ, Med Ctr, Dept Neurosurg, Stanford, CA 94305 USA.
RP Maruta, J (reprint author), Brain Trauma Fdn, World Trade Ctr 7, 34th Floor,250 Greenwich St, New York, NY 10007 USA.
OI Maruta, Jun/0000-0002-5054-6605
FU CDMRP [W81XWH-08-2-0646]; USAMRMC [W81XWH-08-1-0021]; James S. McDonnell
Foundation
FX This work was supported by CDMRP W81XWH-08-2-0646, USAMRMC
W81XWH-08-1-0021, and James S. McDonnell Foundation.
NR 18
TC 5
Z9 5
U1 3
U2 10
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
EI 1930-613X
J9 MIL MED
JI Milit. Med.
PD JUN
PY 2014
VL 179
IS 6
BP 619
EP 625
DI 10.7205/MILMED-D-13-00420
PG 7
WC Medicine, General & Internal
SC General & Internal Medicine
GA AN7UM
UT WOS:000340806500006
PM 24902128
ER
PT J
AU Mooney, SR
Horton, PA
Trakowski, JH
Lenard, JH
Barron, MR
Nave, PV
Gautreaux, MS
Lott, HD
AF Mooney, Scott R.
Horton, Philip A.
Trakowski, John H., Jr.
Lenard, Janet H.
Barron, Mark R.
Nave, Peggy V.
Gautreaux, Melissa S.
Lott, Heather D.
TI Military Inpatient Residential Treatment of Substance Abuse Disorders:
The Eisenhower Army Medical Center Experience
SO MILITARY MEDICINE
LA English
DT Article
ID VETERANS
AB Opened in 2009, the Dwight D. Eisenhower Army Medical Center Inpatient Residential Treatment Facility (RTF) is the largest and most well-established inpatient substance use disorder treatment facility in the Department of Defense. The RTF is a 28-day inpatient treatment program that employs evidence-based practices and is based on Alcoholics/Narcotics Anonymous principles that are incorporated with a hybrid of military daily structure regime including early morning physical training. Family involvement is encouraged. The RTF is staffed by a multidisciplinary team specializing in addictions and admits Active/Activated Service Members (SMs) from all Service branches, typically those who have failed other military/civilian substance use disorder programs. Eighty-seven percent of SMs referred to the program successfully commenced, with continuous sobriety observed in over half of SMs 6 months later, and 1 year relapse rates comparable to other alcohol treatment programs. Limitations of our program evaluation efforts, lessons learned, and recommendations for the way ahead are shared.
C1 [Mooney, Scott R.; Horton, Philip A.; Trakowski, John H., Jr.; Barron, Mark R.; Nave, Peggy V.; Gautreaux, Melissa S.; Lott, Heather D.] Dwight D Eisenhower Army Med Ctr, Ft Gordon, GA 30905 USA.
RP Mooney, SR (reprint author), Dwight D Eisenhower Army Med Ctr, 300 E Hosp Rd, Ft Gordon, GA 30905 USA.
NR 15
TC 0
Z9 0
U1 0
U2 6
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
EI 1930-613X
J9 MIL MED
JI Milit. Med.
PD JUN
PY 2014
VL 179
IS 6
BP 674
EP 678
DI 10.7205/MILMED-D-13-00308
PG 5
WC Medicine, General & Internal
SC General & Internal Medicine
GA AN7UM
UT WOS:000340806500014
PM 24902136
ER
PT J
AU Chae, JJ
Mulreany, DG
Quo, QY
Lu, QZ
Choi, JS
Strehin, L
Espinoza, FA
Schein, O
Trexler, MM
Bower, KS
Elisseeff, JH
AF Chae, Jemin J.
Mulreany, Daniel G.
Quo, Qiongyu
Lu, Qiaozhi
Choi, Joseph S.
Strehin, Lossif
Espinoza, Freddy A.
Schein, Oliver
Trexler, Morgana M.
Bower, Kraig S.
Elisseeff, Jennifer H.
TI Application of a Collagen-Based Membrane and Chondroitin Sulfate-Based
Hydrogel Adhesive for the Potential Repair of Severe Ocular Surface
Injuries
SO MILITARY MEDICINE
LA English
DT Article
ID NONTRAUMATIC CORNEAL PERFORATION; TECTONIC DRAPE PATCH; AMNIOTIC
MEMBRANE; CYANOACRYLATE GLUE; VITRIGEL MEMBRANES; TISSUE ADHESIVE;
FIBRIN GLUE; EYE; MANAGEMENT; TRAUMA
AB This study was performed to evaluate the potential of a chondroitin sulfate-polyethylene glycol (CS-PEG) adhesive and collagen-based membrane (collagen vitrigel, CV) combination as a method to treat penetrating ocular injuries on the battlefield and to improve this method with two technologies: an antibiotic releasing CS-PEG adhesive and a corneal shaped CV. Burst testing using porcine cadaveric eyes, high-performance liquid chromatography, the Kirby-Bauer bacterial inhibition test, and CV implantations on the live and cadaveric rabbit eyes were performed. The ocular burst test showed CS-PEG adhesive could successfully repair 5-mm to 6-mm length wounds in the corneal and corneoscleral regions but would require CS-PEG + CV to treat larger wounds similar to those seen on the battlefield. In addition, high performance liquid chromatography and the Kirby-Bauer bacterial inhibition test presented evidence suggesting the vancomycin incorporated CS-PEG could inhibit Staphylococcus infection for 9 days. Furthermore, the curved CV showed an advantage by matching the corneal contour without any wrinkle formation. Although this pilot study showed a limited range of possible applications, we demonstrated that the combination of CS-PEG adhesive + CV is a promising method and the 2 technologies improve their applicability to the special demands of the battlefield.
C1 [Chae, Jemin J.; Mulreany, Daniel G.; Quo, Qiongyu; Lu, Qiaozhi; Choi, Joseph S.; Strehin, Lossif; Espinoza, Freddy A.; Elisseeff, Jennifer H.] Johns Hopkins Univ, Wilmer Eye Inst, Translat Tissue Engn Ctr, Baltimore, MD 21287 USA.
[Chae, Jemin J.; Mulreany, Daniel G.; Quo, Qiongyu; Lu, Qiaozhi; Choi, Joseph S.; Strehin, Lossif; Espinoza, Freddy A.; Elisseeff, Jennifer H.] Johns Hopkins Univ, Dept Biomed Engn, Baltimore, MD 21287 USA.
[Schein, Oliver; Bower, Kraig S.; Elisseeff, Jennifer H.] Johns Hopkins Univ, Dept Ophthalmol, Baltimore, MD 21287 USA.
[Trexler, Morgana M.] Johns Hopkins Univ, Appl Phys Lab, Res & Exploratory Dev Dept, Laurel, MD 20723 USA.
[Bower, Kraig S.] Walter Reed Army Med Ctr, Ophthalmol Serv, Bethesda, MD 20889 USA.
RP Chae, JJ (reprint author), Johns Hopkins Univ, Wilmer Eye Inst, Translat Tissue Engn Ctr, 400 N Wolfe St, Baltimore, MD 21287 USA.
RI Guo, Qiongyu/J-3118-2014
FU Congressionally Directed Medical Research Program under the U.S. Army
Medical Research and Materiel Command at Fort Detrick, MD
[W81XWH-09-2-0173]; Research to Prevent Blindness
FX Authors would like to acknowledge Dr. Toshiaki Takezawa for his
assistance with CV synthesis technique. This study was funded by the
Congressionally Directed Medical Research Program under the U.S. Army
Medical Research and Materiel Command at Fort Detrick, MD (Contract No
W81XWH-09-2-0173, Program Manager Dr. Dwayne Taliaferro) and the Jules
Stein Professorship from Research to Prevent Blindness.
NR 31
TC 6
Z9 6
U1 2
U2 16
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
EI 1930-613X
J9 MIL MED
JI Milit. Med.
PD JUN
PY 2014
VL 179
IS 6
BP 686
EP 694
DI 10.7205/MILMED-D-13-00360
PG 9
WC Medicine, General & Internal
SC General & Internal Medicine
GA AN7UM
UT WOS:000340806500016
PM 24902138
ER
PT J
AU Sherry, DM
AF Sherry, David M.
TI IF A TREE FALLS IN THE WOODS AND THE GOVERNMENT DID NOTHING TO CAUSE IT,
DOES IT STILL INVOKE THE ENDANGERED SPECIES ACT? EVALUATING KARUK TRIBE
V. U.S. FOREST SERVICE AND ITS IMPACT ON AGENCY ACTION UNDER THE ESA
SO MILITARY LAW REVIEW
LA English
DT Article
RP Sherry, DM (reprint author), US Army, Judge Advocate Gen Sch TJAGLCS, Ctr Law & Mil Operat, Charlottesville, VA 22911 USA.
NR 7
TC 0
Z9 0
U1 3
U2 5
PU JUDGE ADVOCATE GENERALS SCHOOL
PI CHARLOTTESVILLE
PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 USA
SN 0026-4040
J9 MIL LAW REV
JI Milit. Law Rev.
PD SUM
PY 2014
VL 220
BP 316
EP 343
PG 28
WC Law
SC Government & Law
GA AN1EE
UT WOS:000340324700008
ER
PT J
AU Preece, BL
Olson, JT
Reynolds, JP
Fanning, JD
Haefner, DP
AF Preece, Bradley L.
Olson, Jeffrey T.
Reynolds, Joseph P.
Fanning, Jonathan D.
Haefner, David P.
TI Human vision noise model validation for the US Army sensor performance
metric
SO OPTICAL ENGINEERING
LA English
DT Article
DE human vision; noise; contrast threshold function; targeting task
performance metric; image evaluation; night vision integrated
performance model
AB Image noise originating from a sensor system is often the limiting factor in target acquisition performance, especially when limited by atmospheric transmission or low-light conditions. To accurately predict target acquisition range performance for a wide variety of imaging systems, image degradation introduced by the sensor must be properly combined with the limitations of the human visual system (HVS). This crucial step of incorporating the HVS has been improved and updated within NVESD's latest imaging system performance model. The new noise model discussed here shows how an imaging system's noise and blur are combined with the contrast threshold function (CTF) to form the system CTF. Model calibration constants were found by presenting low-contrast sine gratings with additive noise in a two alternative forced choice experiment. One of the principal improvements comes from adding an eye photon noise term allowing the noise CTF to be accurate over a wide range of luminance. The latest HVS noise model is then applied to the targeting task performance metric responsible for predicting system performance from the system CTF. To validate this model, human target acquisition performance was measured from a series of infrared and visible-band noise-limited imaging systems. (C) 2014 Society of Photo-Optical Instrumentation Engineers (SPIE)
C1 [Preece, Bradley L.; Olson, Jeffrey T.; Reynolds, Joseph P.; Fanning, Jonathan D.; Haefner, David P.] US Army, RDECOM CERDEC Night Vis Elect Sensors Directorate, Ft Belvoir, VA 22060 USA.
RP Preece, BL (reprint author), US Army, RDECOM CERDEC Night Vis Elect Sensors Directorate, Ft Belvoir, VA 22060 USA.
EM bradley.l.preece.civ@mail.mil
NR 21
TC 5
Z9 5
U1 0
U2 4
PU SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS
PI BELLINGHAM
PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98225 USA
SN 0091-3286
EI 1560-2303
J9 OPT ENG
JI Opt. Eng.
PD JUN
PY 2014
VL 53
IS 6
AR 061712
DI 10.1117/1.OE.53.6.061712
PG 14
WC Optics
SC Optics
GA AN5ZR
UT WOS:000340672800015
ER
PT J
AU Tong, XL
Luke, EA
Smith, R
AF Tong, Xiaoling
Luke, Edward A.
Smith, Robert
TI Numerical validation of a near-field fugitive dust model for vehicles
moving on unpaved surfaces
SO PROCEEDINGS OF THE INSTITUTION OF MECHANICAL ENGINEERS PART D-JOURNAL OF
AUTOMOBILE ENGINEERING
LA English
DT Article
DE Fugitive dust emissions; computational fluid dynamics; multiphase flow;
PM10; tire; tyre
ID DISPERSION; WIND; EMISSIONS; LAYER
AB This paper presents a numerical model for evaluating fugitive dust emissions and transport in a near field induced by a moving vehicle. The dust emission model describes the quantity and location of emitted dust. The transport of the dust is recorded by the Lagrangian particle-tracking method, and the turbulence dispersion of particles is modeled stochastically. The presented model is validated numerically for the prediction of dust concentration in a region near the vehicles through a careful comparison with the available experimental data. The simulation results compare reasonably well with the experimental data. This model provides, for the first time, a validated dust emission and transport model suitable for the near field of moving vehicles.
C1 [Tong, Xiaoling] Mississippi State Univ, Ctr Adv Vehicular Syst, Starkville, MS 39759 USA.
[Luke, Edward A.] Mississippi State Univ, Dept Comp Sci, Starkville, MS 39759 USA.
[Smith, Robert] US Army Res Dev & Engn Command, Tank Automot Res Dev & Engn Ctr, Warren, MI USA.
RP Tong, XL (reprint author), Mississippi State Univ, Simctr, Ctr Adv Vehicular Syst, 2 Res Blvd, Starkville, MS 39759 USA.
EM xltong@cavs.msstate.edu
FU US Army TACOM Life Cycle Command through Mississippi State University
[W56HZV-08-C-0236]
FX This work was supported by the US Army TACOM Life Cycle Command
(contract number W56HZV-08-C-0236), through a subcontract with
Mississippi State University, and was performed for the Simulation Based
Reliability and Safety (SimBRS) research program.
NR 42
TC 0
Z9 0
U1 0
U2 5
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 0954-4070
EI 2041-2991
J9 P I MECH ENG D-J AUT
JI Proc. Inst. Mech. Eng. Part D-J. Automob. Eng.
PD JUN
PY 2014
VL 228
IS 7
BP 747
EP 757
DI 10.1177/0954407013512291
PG 11
WC Engineering, Mechanical; Transportation Science & Technology
SC Engineering; Transportation
GA AM9XU
UT WOS:000340235100004
ER
PT J
AU Rao, SS
Prater, JT
Wu, F
Nori, S
Kumar, D
Yue, L
Liou, SH
Narayan, J
AF Rao, S. S.
Prater, J. T.
Wu, Fan
Nori, S.
Kumar, D.
Yue, L.
Liou, S. -H.
Narayan, J.
TI Positive exchange bias in epitaxial permalloy/MgO integrated with Si
(100)
SO CURRENT OPINION IN SOLID STATE & MATERIALS SCIENCE
LA English
DT Review
DE Positive exchange bias; Permalloy islands; Epitaxial integration; Pulsed
laser deposition; Domain matching epitaxy
ID BILAYERS; FILMS; NANOPARTICLES; DEPENDENCE; THICKNESS; NIO; MGO
AB In magnetic random access memory (MRAM) devices, soft magnetic thin film elements such as permalloy (Py) are used as unit cells of information. The epitaxial integration of these elements with the technologically important substrate Si (1 0 0) and a thorough understanding of their magnetic properties are critical for CMOS-based magnetic devices. We report on the epitaxial growth of Ni82.5Fe17.5 (permalloy, Py) on Si (1 0 0) using a TiN/MgO buffer layer. Initial stages of growth are characterized by the formation of discrete islands that gradually merge into a continuous film as deposition times are extended. Interestingly, we find that the magnetic features of Py films in early stages of island coalescence are distinctly different from the films formed initially (discrete islands) and after extended deposition times (narrow distribution of equiaxed granular films). Isothermal in-plane and out-of-plane magnetic measurements performed on these transitional films show highly anisotropic magnetic behavior with an easy magnetization axis lying in the plane of the film. Importantly, when this sample is zero-field cooled, a positive exchange bias and vertical loop shift are observed, unusual for a soft ferromagnet like Py. Repeated field cycling and hysteresis loops up to the fields of 7T produced reproducible hysteresis loops indicating the existence of strongly pinned spin configurations. Classical interface related exchange bias models cannot explain the observed magnetic features of the transitional Py films. We believe that the anomalous magnetic behavior of such Py films may be explained by considering the highly irregular morphology that develops at intermediate growth times that are possibly also undergoing a transition from Bloch to Neel domain wall structures as a function of Py island size. This study broadens the current understanding of magnetic properties of Py thin layers for technological applications in magneto-electronic devices, integrated with Si (1 0 0). (C) 2014 Elsevier Ltd. All rights reserved.
C1 [Rao, S. S.; Prater, J. T.] Army Res Off, Div Mat Sci, Res Triangle Pk, NC 27709 USA.
[Rao, S. S.; Prater, J. T.; Wu, Fan; Nori, S.] N Carolina State Univ, Dept Mat Sci & Engn, Raleigh, NC 27695 USA.
[Kumar, D.] North Carolina A&T Univ, Ctr Adv Mat & Smart Struct, Greensboro, NC 27411 USA.
[Yue, L.; Liou, S. -H.; Narayan, J.] Univ Nebraska, Dept Phys, Lincoln, NE 68588 USA.
RP Rao, SS (reprint author), N Carolina State Univ, Dept Mat Sci & Engn, Box 7907, Raleigh, NC 27695 USA.
EM ssingam@ncsu.edu
RI Nori, Sudhakar/E-8111-2010;
OI , fan/0000-0001-5000-0592
FU State of North Carolina; National Science Foundation
FX Also, the authors acknowledge the use of the Analytical Instrumentation
Facility (AIF) at North Carolina State University, which is supported by
the State of North Carolina and the National Science Foundation.
NR 37
TC 10
Z9 10
U1 7
U2 44
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 1359-0286
EI 1879-0348
J9 CURR OPIN SOLID ST M
JI Curr. Opin. Solid State Mat. Sci.
PD JUN
PY 2014
VL 18
IS 3
BP 140
EP 146
DI 10.1016/j.cossms.2014.02.001
PG 7
WC Materials Science, Multidisciplinary; Physics, Applied; Physics,
Condensed Matter
SC Materials Science; Physics
GA AM2SL
UT WOS:000339701000002
ER
PT J
AU Tipping, PW
Sosa, A
Pokorny, EN
Foley, J
Schmitz, DC
Lane, JS
Rodgers, L
Mccloud, L
Livingston-Way, P
Cole, MS
Nichols, G
AF Tipping, Philip W.
Sosa, Alejandro
Pokorny, Eileen N.
Foley, Jeremiah
Schmitz, Don C.
Lane, Jon S.
Rodgers, Leroy
Mccloud, Lori
Livingston-Way, Pam
Cole, Matthew S.
Nichols, Gary
TI RELEASE AND ESTABLISHMENT OF MEGAMELUS SCUTELLARIS (HEMIPTERA:
DELPHACIDAE) ON WATERHYACINTH IN FLORIDA
SO FLORIDA ENTOMOLOGIST
LA English
DT Editorial Material
DE Megamelus scutellaris; Eichhornia crassipes; establishment
AB More than 73,000 Megamelus scutellaris (Hemiptera: Delphacidae) were released in Florida over a 2 to 3 yr period at 10 sites in an attempt to establish sustainable populations on waterhyacinth, Eichhornia crassipes Mart. Solms (Commelinales: Pontederiaceae). Insect populations persisted at most sites including those furthest north and consecutive overwintering was confirmed in as many as three times at some sites. Establishment appeared to be promoted at sites with some cover or shading compared to open areas. Insects readily dispersed over short distances which made detection and monitoring difficult.
C1 [Tipping, Philip W.; Pokorny, Eileen N.; Foley, Jeremiah] ARS, USDA, Invas Plant Res Lab, Davie, FL 33314 USA.
[Sosa, Alejandro] FUEDEI Simon Bolivar 1559, Buenos Aires, DF, Argentina.
[Schmitz, Don C.] Florida Fish & Wildlife Conservat Commiss, Tallahassee, FL 32399 USA.
[Lane, Jon S.] US Army Corps Engineers, Jacksonville, FL 32207 USA.
[Rodgers, Leroy] South Florida Water Management Dist, W Palm Beach, FL 33406 USA.
[Mccloud, Lori; Livingston-Way, Pam; Cole, Matthew S.; Nichols, Gary] St Johns River Water Management Dist, Palatka, FL 32178 USA.
RP Tipping, PW (reprint author), ARS, USDA, Invas Plant Res Lab, 3225 Coll Ave, Davie, FL 33314 USA.
EM philip.tipping@ars.usda.gov
NR 5
TC 4
Z9 4
U1 1
U2 9
PU FLORIDA ENTOMOLOGICAL SOC
PI LUTZ
PA 16125 E LAKE BURRELL DR, LUTZ, FL 33548 USA
SN 0015-4040
EI 1938-5102
J9 FLA ENTOMOL
JI Fla. Entomol.
PD JUN
PY 2014
VL 97
IS 2
BP 804
EP 806
PG 3
WC Entomology
SC Entomology
GA AM2CX
UT WOS:000339657600064
ER
PT J
AU Lebaron, N
Zhang, X
Herrell, R
Yung, E
Iskric, A
Cho, S
Low, N
AF Lebaron, N.
Zhang, X.
Herrell, R.
Yung, E.
Iskric, A.
Cho, S.
Low, N.
TI Anxious and suicidal behaviors among relatives are associated with
suicide attempts and hospitalizations in mood disorder subjects
SO INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
LA English
DT Meeting Abstract
CT 29th CINP World Congress of Neuropsychopharmacology
CY JUN 22-26, 2014
CL Vancouver, CANADA
SP CINP
C1 [Lebaron, N.; Zhang, X.; Yung, E.; Iskric, A.; Cho, S.; Low, N.] McGill Univ, Montreal, PQ, Canada.
[Herrell, R.] Walter Reed Army Inst Res, Silver Spring, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU CAMBRIDGE UNIV PRESS
PI NEW YORK
PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA
SN 1461-1457
EI 1469-5111
J9 INT J NEUROPSYCHOPH
JI Int. J. Neuropsychopharmacol.
PD JUN
PY 2014
VL 17
SI 1
MA P-51-001
BP 165
EP 165
PG 1
WC Clinical Neurology; Neurosciences; Pharmacology & Pharmacy; Psychiatry
SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry
GA AM3RB
UT WOS:000339769200627
ER
PT J
AU Keller, CB
AF Keller, Christian B.
TI German Immigrants, Race, and Citizenship in the Civil War Era
SO JOURNAL OF AMERICAN HISTORY
LA English
DT Book Review
C1 [Keller, Christian B.] US Army War Coll, Carlisle, PA 17013 USA.
RP Keller, CB (reprint author), US Army War Coll, Carlisle, PA 17013 USA.
NR 1
TC 0
Z9 0
U1 0
U2 0
PU ORGANIZATION AMER HISTORIANS
PI BLOOMINGTON
PA 112 N BRYAN ST, BLOOMINGTON, IN 47408 USA
SN 0021-8723
EI 1945-2314
J9 J AM HIST
JI J. Am. Hist.
PD JUN
PY 2014
VL 101
IS 1
BP 271
EP 272
DI 10.1093/jahist/jau249
PG 4
WC History
SC History
GA AM5JG
UT WOS:000339893000068
ER
PT J
AU Tolisano, AM
Bager, JM
AF Tolisano, Anthony M.
Bager, Jennifer M.
TI Sleep Surgery and Medical Malpractice
SO LARYNGOSCOPE
LA English
DT Article
DE Sleep surgery; medical malpractice
ID NEGLIGENCE CLAIMS; LITIGATION; GLAND
AB Objectives/Hypothesis: To describe and analyze the causes and outcomes of lawsuits pertaining to sleep surgery to mitigate future litigation and improve physician education.
Study Design: A retrospective review of a publicly available database containing jury verdicts and settlements.
Methods: The LexisNexis MEGA Jury Verdicts and Settlements database was reviewed for all lawsuits including settlements and trial verdicts related to sleep surgery. Data including type of surgery performed, plaintiff allegation, nature of injury, outcomes, and indemnities were collected and analyzed.
Results: Fifty-one cases met the inclusion criteria. Of these, 30 were decided by a jury, nine were settled out of court, and 10 were resolved by other means. Overall, 57% of known outcomes favored the defendant. The most common surgery performed was tonsillectomy (57%), followed by uvulopalatopharyngoplasty (45%), adenoidectomy (31%), and septoplasty (31%). No difference was found between outcomes when comparing the most common injuries cited, including wrongful death (P = .572), airway compromise (P = .376), and drug reaction (P = .443). If failure to recognize a complication (P = .034) or delay in diagnosis (P = .026) was a component of the legal allegations, the outcome significantly favored the plaintiff. The median settlement ($545,000) and plaintiff award ($1.45 million) were not significantly different (P = .13).
Conclusions: The majority of outcomes favored the defendant. Type of injury did not predict outcome. Failure to recognize complications and delay in diagnosis strongly predicted a verdict in favor of the plaintiff.
C1 [Tolisano, Anthony M.; Bager, Jennifer M.] Tripler Army Med Ctr, Dept Otolaryngol, Honolulu, HI 96859 USA.
RP Tolisano, AM (reprint author), Tripler Army Med Ctr, Dept Otolaryngol, 1 Jarrett White Rd, Honolulu, HI 96859 USA.
EM anthony.m.tolisano.mil@mail.mil
NR 17
TC 4
Z9 4
U1 1
U2 2
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0023-852X
EI 1531-4995
J9 LARYNGOSCOPE
JI Laryngoscope
PD JUN
PY 2014
VL 124
IS 6
BP E250
EP E254
DI 10.1002/lary.24559
PG 5
WC Medicine, Research & Experimental; Otorhinolaryngology
SC Research & Experimental Medicine; Otorhinolaryngology
GA AL9SF
UT WOS:000339480400008
PM 24347364
ER
PT J
AU Song, DJ
Lanzi, JT
Groth, AT
Drake, M
Orchowski, JR
Shaha, SH
Lindell, KK
AF Song, Daniel J.
Lanzi, Joseph T.
Groth, Adam T.
Drake, Matthew
Orchowski, Joseph R.
Shaha, Steven H.
Lindell, Kenneth K.
TI The Effect of Syndesmosis Screw Removal on the Reduction of the Distal
Tibiofibular Joint: A Prospective Radiographic Study
SO FOOT & ANKLE INTERNATIONAL
LA English
DT Article
DE syndesmosis; syndesmosis malreduction; ankle fracture
ID ANKLE FRACTURES; FIXATION; MALREDUCTION
AB Background: Injury to the tibiofibular syndesmosis is frequent with rotational ankle injuries. Multiple studies have shown a high rate of syndesmotic malreduction with the placement of syndesmotic screws. There are no studies evaluating the reduction or malreduction of the syndesmosis after syndesmotic screw removal. The purpose of this study was to prospectively evaluate syndesmotic reduction with CT scans and to determine the effect of screw removal on the malreduced syndesmosis.
Methods: This was an IRB-approved prospective radiographic study. Patients over 18 years of age treated at 1 institution between August 2008 and December 2011 with intraoperative evidence of syndesmotic disruption were enrolled. Postoperative CT scans were obtained of bilateral ankles within 2 weeks of operative fixation. Syndesmotic screws were removed after 3 months, and a second CT scan was then obtained 30 days after screw removal. Using axial CT images, syndesmotic reduction was evaluated compared to the contralateral uninjured ankle. Twenty-five patients were enrolled in this prospective study. The average age was 25.7 (range, 19 to 35), with 3 females and 22 males.
Results: Nine patients (36%) had evidence of tibiofibular syndesmosis malreduction on their initial postoperative axial CT scans. In the postsyndesmosis screw removal CT scan, 8 of 9 or 89% of malreductions showed adequate reduction of the tibiofibular syndesmosis. There was a statistically significant reduction in syndesmotic malreductions (t = 3.333, P<.001) between the initial rate of malreduction after screw placement of 36% (9/25) and the rate of malreduction after all screws were removed of 4% (1/25).
Conclusions: Despite a high rate of initial malreduction (36%) after syndesmosis screw placement, 89% of the malreduced syndesmoses spontaneously reduced after screw removal. Syndesmotic screw removal may be advantageous to achieve final anatomic reduction of the distal tibiofibular joint, and we recommend it for the malreduced syndesmosis.
Level of Evidence: Level IV, prognostic case series.
C1 [Song, Daniel J.] Landstuhl Reg Med Ctr, Orthopaed Surg Serv, Landstuhl, Germany.
[Lanzi, Joseph T.; Groth, Adam T.; Drake, Matthew; Orchowski, Joseph R.; Lindell, Kenneth K.] Tripler Army Med Ctr, Honolulu, HI USA.
[Shaha, Steven H.] Univ Utah, Ctr Policy & Publ Adm, Salt Lake City, UT USA.
[Shaha, Steven H.] Allscripts, Chicago, IL USA.
RP Song, DJ (reprint author), Landstuhl Reg Med Ctr, Orthopaed Surg Serv, APO, CMR 402 Box 445,AE 09180, Landstuhl, Germany.
EM danieljsong@gmail.com
RI Groth, Adam/P-9366-2016
OI Groth, Adam/0000-0003-2475-6200
NR 14
TC 13
Z9 15
U1 0
U2 2
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1071-1007
EI 1944-7876
J9 FOOT ANKLE INT
JI Foot Ankle Int.
PD JUN
PY 2014
VL 35
IS 6
BP 543
EP 548
DI 10.1177/1071100714524552
PG 6
WC Orthopedics
SC Orthopedics
GA AL7QN
UT WOS:000339329800002
PM 24532699
ER
PT J
AU Nataraj, L
Jackson, A
Giri, L
Atwater, T
Hubbard, C
Bundy, M
AF Nataraj, Latha
Jackson, Aaron
Giri, Lily
Atwater, Terrill
Hubbard, Clifford
Bundy, Mark
TI Synthesis and Characterization of Doped Group-IV Semiconductor
Nanocrystals
SO NANOSCIENCE AND NANOTECHNOLOGY LETTERS
LA English
DT Article
DE Germanium; Doped Nanocrystals; Optoelectronic Properties
ID SILICON
AB Doped semiconductor nanocrystals show great promise for several applications in microelectronics and integrated optoelectronics. Nanocrystal based technology has the potential to revolutionize several fields of technology such as thin conducting films, light emitting devices, tunable lasers, transistors, and photovoltaics, and to provide less harmful alternatives to toxic fluorescent dyes for application in bio-imaging, to name a few. While properties of nanocrystals are clearly dependent on their size, considerable research is underway to explore the influence of dopants on the properties of semiconductor nanocrystals. The nanoscale dimensions make elusive the introduction of dopants into these confined structures. Also, there is the possibility of making them degenerate even with the addition of very small quantities of the dopant. Here, we present a facile, low-cost procedure that we have developed for the synthesis of non-degenerate doped semiconductor nanocrystals and study their properties.
C1 [Nataraj, Latha; Jackson, Aaron; Giri, Lily; Atwater, Terrill; Hubbard, Clifford; Bundy, Mark] US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA.
RP Nataraj, L (reprint author), US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA.
NR 18
TC 0
Z9 0
U1 4
U2 16
PU AMER SCIENTIFIC PUBLISHERS
PI VALENCIA
PA 26650 THE OLD RD, STE 208, VALENCIA, CA 91381-0751 USA
SN 1941-4900
EI 1941-4919
J9 NANOSCI NANOTECH LET
JI Nanosci. Nanotechnol. Lett.
PD JUN
PY 2014
VL 6
IS 6
BP 502
EP 504
DI 10.1166/nnl.2014.1797
PG 3
WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary;
Physics, Applied
SC Science & Technology - Other Topics; Materials Science; Physics
GA AL8ZJ
UT WOS:000339428200009
ER
PT J
AU Simpson, D
Post, PG
Young, G
Jensen, PR
AF Simpson, Duncan
Post, Phillip G.
Young, Greg
Jensen, Peter R.
TI "It's Not About Taking the Easy Road": The Experiences of Ultramarathon
Runners
SO SPORT PSYCHOLOGIST
LA English
DT Article
DE endurance; running; phenomenology; sport psychology
ID PHENOMENOLOGY; PARTICIPANTS
AB Ultramarathon (UM) running is a rapidly growing sport throughout the world, yet to date it has received little attention in sport psychology literature. To obtain further insight into this sport, the current study examined the training and competition experiences of UM runners. Phenomenological interviews were conducted with 26 participants ranging in age from 32 to 67 years (M = 44.1 yrs, SD = 8.1). Qualitative analysis of the interview data identified meaning units, which were grouped into major themes. A final thematic structure revealed five major themes that characterized the participant's experience of UM running: preparation and strategy, management, discovery, personal achievement, and community. Taken together, the present results extend previous research on UM running and provide a number of suggestions for sport psychology consultants working with UM runners.
C1 [Simpson, Duncan] Barry Univ, Dept Sport & Exercise Sci, Miami, FL 33161 USA.
[Post, Phillip G.] New Mexico State Univ, Dept Human Performance Dance & Recreat, Las Cruces, NM 88003 USA.
[Young, Greg] Liverpool John Moores Univ, Dept Phys Educ Sport Dev & Coaching, Liverpool L3 5UX, Merseyside, England.
[Jensen, Peter R.] US Mil Acad, Ctr Enhanced Performance, West Point, NY 10996 USA.
RP Simpson, D (reprint author), Barry Univ, Dept Sport & Exercise Sci, Miami, FL 33161 USA.
EM Dsimpson@mail.barry.edu
NR 33
TC 4
Z9 4
U1 2
U2 19
PU HUMAN KINETICS PUBL INC
PI CHAMPAIGN
PA 1607 N MARKET ST, PO BOX 5076, CHAMPAIGN, IL 61820-2200 USA
SN 0888-4781
EI 1543-2793
J9 SPORT PSYCHOL
JI Sport Psychol.
PD JUN
PY 2014
VL 28
IS 2
BP 176
EP 185
DI 10.1123/tsp.2013-0064
PG 10
WC Hospitality, Leisure, Sport & Tourism; Psychology, Applied; Psychology;
Sport Sciences
SC Social Sciences - Other Topics; Psychology; Sport Sciences
GA AL6WP
UT WOS:000339274500006
ER
PT J
AU Heine, HS
Louie, A
Adamovicz, JJ
Amemiya, K
Fast, RL
Miller, L
Opal, SM
Palardy, J
Parejo, NA
Sorgel, F
Kinzig-Schippers, M
Drusano, GL
AF Heine, Henry S.
Louie, Arnold
Adamovicz, Jeffrey J.
Amemiya, Kei
Fast, Randy L.
Miller, Lynda
Opal, Steven M.
Palardy, John
Parejo, Nicolas A.
Soergel, Fritz
Kinzig-Schippers, Martina
Drusano, George L.
TI Evaluation of Imipenem for Prophylaxis and Therapy of Yersinia pestis
Delivered by Aerosol in a Mouse Model of Pneumonic Plague
SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
LA English
DT Article
ID LIPOPOLYSACCHARIDE; INTERLEUKIN-10; PHARMACOKINETICS; PHARMACODYNAMICS;
TEMPERATURE; CILASTATIN; INTERFERON; MONOCYTES; INFECTION; CYTOKINES
AB It has been previously shown that mice subjected to an aerosol exposure to Yersinia pestis and treated with beta-lactam antibiotics after a delay of 42 h died at an accelerated rate compared to controls. It was hypothesized that endotoxin release in antibiotic-treated mice accounted for the accelerated death rate in the mice exposed to aerosol Y. pestis. Imipenem, a beta-lactam antibiotic, binds to penicillin binding protein 2 with the highest affinity and produces rounded cells. The binding of imipenem causes cells to lyse quickly and thereby to release less free endotoxin. Two imipenem regimens producing fractions of time that the concentration of free, unbound drug was above the MIC (fT > MIC) of approximately 25% (6/24 h) and 40% (9.5/24 h) were evaluated. In the postexposure prophylaxis study, the 40% and 25% regimens produced 90% and 40% survivorship, respectively. In the 42-h treatment study, both regimens demonstrated a 40 to 50% survivorship at therapy cessation and some deaths thereafter, resulting in a 30% survivorship. As this was an improvement over the results with other beta-lactams, a comparison of both endotoxin and cytokine levels in mice treated with imipenem and ceftazidime (a beta-lactam previously demonstrated to accelerate death in mice during treatment) was performed and supported the original hypotheses; however, the levels observed in animals treated with ciprofloxacin (included as an unrelated antibiotic that is also bactericidal but should cause little lysis due to a different mode of action) were elevated and significantly (7-fold) higher than those with ceftazidime.
C1 [Heine, Henry S.; Louie, Arnold; Drusano, George L.] Univ Florida, Res & Acad Ctr, Inst Innovat Therapeut, Orlando, FL 32816 USA.
[Adamovicz, Jeffrey J.] Univ Wyoming, Laramie, WY 82071 USA.
[Amemiya, Kei; Fast, Randy L.; Miller, Lynda] US Army Med Res Inst Infect Dis, Ft Detrick, MD USA.
[Opal, Steven M.; Palardy, John; Parejo, Nicolas A.] Brown Univ, Alpert Med Sch, Providence, RI 02912 USA.
[Soergel, Fritz; Kinzig-Schippers, Martina] Inst Biomed & Pharmaceut Res, Nurnberg, Germany.
[Soergel, Fritz] Univ Duisburg Essen, Fac Med, Inst Pharmacol, Duisburg, Germany.
RP Heine, HS (reprint author), Univ Florida, Res & Acad Ctr, Inst Innovat Therapeut, Orlando, FL 32816 USA.
EM hsheine@ufl.edu
FU Defense Threat Reduction Agency [CB2544]; JSTO/DTRA [1.1A0018_07_RD_B];
[1 PO1 AI060908-01A1]
FX The research described here was sponsored by 1 PO1 AI060908-01A1, a
Program Project Grant to G.L.D. and the Defense Threat Reduction Agency,
and project no. CB2544 to H.S.H. In addition, funding from JSTO/DTRA,
project no. 1.1A0018_07_RD_B, to K.A. is acknowledged.
NR 31
TC 2
Z9 2
U1 0
U2 6
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0066-4804
EI 1098-6596
J9 ANTIMICROB AGENTS CH
JI Antimicrob. Agents Chemother.
PD JUN
PY 2014
VL 58
IS 6
BP 3276
EP 3284
DI 10.1128/AAC.02420-14
PG 9
WC Microbiology; Pharmacology & Pharmacy
SC Microbiology; Pharmacology & Pharmacy
GA AK9VP
UT WOS:000338776900036
PM 24687492
ER
PT J
AU Salje, H
Rodriguez-Barraquer, I
Rainwater-Lovett, K
Nisalak, A
Thaisomboonsuk, B
Thomas, SJ
Fernandez, S
Jarman, RG
Yoon, IK
Cummings, DAT
AF Salje, Henrik
Rodriguez-Barraquer, Isabel
Rainwater-Lovett, Kaitlin
Nisalak, Ananda
Thaisomboonsuk, Butsaya
Thomas, Stephen J.
Fernandez, Stefan
Jarman, Richard G.
Yoon, In-Kyu
Cummings, Derek A. T.
TI Variability in Dengue Titer Estimates from Plaque Reduction
Neutralization Tests Poses a Challenge to Epidemiological Studies and
Vaccine Development
SO PLOS NEGLECTED TROPICAL DISEASES
LA English
DT Article
ID AOTUS MONKEYS; DV INFECTION; DNA VACCINE; VIRUS; ANTIBODIES; CHILDREN;
THAILAND; ASSAY; IMMUNOGENICITY; PROTECTION
AB Background: Accurate determination of neutralization antibody titers supports epidemiological studies of dengue virus transmission and vaccine trials. Neutralization titers measured using the plaque reduction neutralization test (PRNT) are believed to provide a key measure of immunity to dengue viruses, however, the assay's variability is poorly understood, making it difficult to interpret the significance of any assay reading. In addition there is limited standardization of the neutralization evaluation point or statistical model used to estimate titers across laboratories, with little understanding of the optimum approach.
Methodology/Principal Findings: We used repeated assays on the same two pools of serum using five different viruses (2,319 assays) to characterize the variability in the technique under identical experimental conditions. We also assessed the performance of multiple statistical models to interpolate continuous values of neutralization titer from discrete measurements from serial dilutions. We found that the variance in plaque reductions for individual dilutions was 0.016, equivalent to a 95% confidence interval of 0.45-0.95 for an observed plaque reduction of 0.7. We identified PRNT75 as the optimum evaluation point with a variance of 0.025 (log(10) scale), indicating a titer reading of 1: 500 had 95% confidence intervals of 1:240-1:1000 (2.70 +/- 0.31 on a log(10) scale). The choice of statistical model was not important for the calculation of relative titers, however, cloglog regression out-performed alternatives where absolute titers are of interest. Finally, we estimated that only 0.7% of assays would falsely detect a four-fold difference in titers between acute and convalescent sera where no true difference exists.
Conclusions: Estimating and reporting assay uncertainty will aid the interpretation of individual titers. Laboratories should perform a small number of repeat assays to generate their own variability estimates. These could be used to calculate confidence intervals for all reported titers and allow benchmarking of assay performance.
C1 [Salje, Henrik; Rodriguez-Barraquer, Isabel; Rainwater-Lovett, Kaitlin; Cummings, Derek A. T.] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD 21205 USA.
[Nisalak, Ananda; Thaisomboonsuk, Butsaya; Fernandez, Stefan; Yoon, In-Kyu] Armed Forces Res Inst Med Sci, Dept Virol, Bangkok 10400, Thailand.
[Thomas, Stephen J.] Walter Reed Army Inst Res, Viral Dis Branch, Silver Spring, MD USA.
[Jarman, Richard G.] Walter Reed Army Inst Res, Div Communicable Dis & Immunol, Silver Spring, MD USA.
RP Salje, H (reprint author), Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD 21205 USA.
EM hsalje1@jhu.edu
OI Salje, Henrik/0000-0003-3626-4254
FU Bill and Melinda Gates Foundation Vaccine Modeling Initiative; National
Institute of General Medical Sciences [U54 GM088491-0109]
FX The study was supported by the Bill and Melinda Gates Foundation Vaccine
Modeling Initiative and the National Institute of General Medical
Sciences (U54 GM088491-0109). The funders had no role in study design,
data collection and analysis, decision to publish, or preparation of the
manuscript.
NR 31
TC 8
Z9 8
U1 0
U2 1
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1935-2735
J9 PLOS NEGLECT TROP D
JI Plos Neglect. Trop. Dis.
PD JUN
PY 2014
VL 8
IS 6
AR e2952
DI 10.1371/journal.pntd.0002952
PG 10
WC Infectious Diseases; Parasitology; Tropical Medicine
SC Infectious Diseases; Parasitology; Tropical Medicine
GA AL0VW
UT WOS:000338846100057
PM 24967885
ER
PT J
AU Sauers, SE
Scofield, DE
AF Sauers, Sarah E.
Scofield, Dennis E.
TI Strength and Conditioning Strategies for Females in the Military
SO STRENGTH AND CONDITIONING JOURNAL
LA English
DT Article
ID UNDULATING PERIODIZED PROGRAMS; PLYOMETRIC TRAINING-PROGRAM;
STRESS-FRACTURES; RISK-FACTORS; COMBINED RESISTANCE; PHYSICAL-FITNESS;
BODY-COMPOSITION; EQUATED VOLUME; INJURIES; WOMEN
AB MILITARY PERSONNEL ARE REQUIRED TO POSSESS A MYRIAD OF PHYSICAL CAPABILITIES THAT DRAW ON ALL FACETS OF PHYSICAL AND MENTAL FITNESS. THE PHYSIOLOGICAL DEMANDS OF MILITARY OCCUPATIONAL TASKS CAN POTENTIALLY CHALLENGE MULTIPLE COMPONENTS OF THE ENERGY SYSTEM CONTINUUM. STRENGTH AND CONDITIONING PROGRAMS FOR FEMALE SOLDIERS SHOULD BE PERIODIZED, TASK-SPECIFIC TRAINING. THIS ARTICLE WILL DISCUSS PEER-REVIEWED RESEARCH REGARDING PHYSICAL RESPONSES TO VARIOUS EXERCISE STIMULI AND MILITARY MOVEMENTS, THE IMPORTANCE OF A PERIODIZED PHYSICAL TRAINING PROGRAM FOR FEMALE SOLDIERS, AND SUGGEST TRAINING STRATEGIES TO IMPROVE PHYSICAL AND MILITARY PERFORMANCE.
C1 [Sauers, Sarah E.; Scofield, Dennis E.] US Army Res Inst Environm Med, Natick, MA 01760 USA.
RP Sauers, SE (reprint author), US Army Res Inst Environm Med, Natick, MA 01760 USA.
RI SCOFIELD, DENNIS/F-3636-2015
NR 41
TC 1
Z9 1
U1 3
U2 12
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1524-1602
EI 1533-4295
J9 STRENGTH COND J
JI Strength Cond. J.
PD JUN
PY 2014
VL 36
IS 3
BP 1
EP 7
PG 7
WC Sport Sciences
SC Sport Sciences
GA AL4KL
UT WOS:000339101700001
ER
PT J
AU Sanamyan, T
Cooper, C
Gilde, G
Sutorik, AC
Dubinskii, M
AF Sanamyan, T.
Cooper, C.
Gilde, G.
Sutorik, A. C.
Dubinskii, M.
TI Fabrication and spectroscopic properties of transparent Nd3+:MgO and
Er3+:MgO ceramics
SO LASER PHYSICS LETTERS
LA English
DT Article
DE MgO; Er-doped; Nd-doped; spectroscopy; laser
ID THERMAL-CONDUCTIVITY; CRYSTALS; LASERS; MGO
AB We present the results of the development and comprehensive characterization of fully densified Er3+:MgO and Nd3+:MgO transparent ceramics fabricated from specially formulated nanopowders. Also presented are the spectroscopic characterization results (absorption, fluorescence and emission lifetimes) of Er3+ and Nd3+ dopant ions in MgO in the temperature range 10 to 300 K. To the best of our knowledge, this is the first reported successful demonstration of bulk MgO host material doped with rare earth (RE) ions. Spectroscopic results are indicative of a single-site RE ion incorporation with a nearly perfect single crystalline environment within the MgO ceramic grains. The results are presented with major emphasis on potential laser application and the outlook for substantially improved laser power scaling at room temperature based on the unique thermal properties of the host material.
C1 [Sanamyan, T.; Dubinskii, M.] RDRL WMM E US Army Res Lab, Adelphi, MD 20783 USA.
[Cooper, C.; Gilde, G.; Sutorik, A. C.] RDRL SEE M US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA.
RP Sanamyan, T (reprint author), RDRL WMM E US Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA.
EM tigran.sanamyan.civ@mail.mil
FU High Energy Laser Joint Technology Office
FX The authors gratefully acknowledge financial support of this work by the
High Energy Laser Joint Technology Office.
NR 18
TC 0
Z9 0
U1 1
U2 20
PU IOP PUBLISHING LTD
PI BRISTOL
PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND
SN 1612-2011
EI 1612-202X
J9 LASER PHYS LETT
JI Laser Phys. Lett.
PD JUN 1
PY 2014
VL 11
IS 6
AR 065801
DI 10.1088/1612-2011/11/6/065801
PG 7
WC Optics; Physics, Applied
SC Optics; Physics
GA AK7YC
UT WOS:000338642700014
ER
PT J
AU Fang, WJ
Hsu, AL
Song, Y
Birdwell, AG
Amani, M
Dubey, M
Dresselhaus, MS
Palacios, T
Kong, J
AF Fang, Wenjing
Hsu, Allen L.
Song, Yi
Birdwell, Anthony G.
Amani, Matin
Dubey, Madan
Dresselhaus, Mildred S.
Palacios, Tomas
Kong, Jing
TI Asymmetric Growth of Bilayer Graphene on Copper Enclosures Using
Low-Pressure Chemical Vapor Deposition
SO ACS NANO
LA English
DT Article
DE bilayer graphene; Cu enclosure; growth mechanism; carbon diffusion
ID LARGE-AREA; HIGH-QUALITY; FILMS; CU; GRAPHITE; NUCLEATION; PYROLYSIS;
SURFACES; KINETICS; HYDROGEN
AB In this work, we investigated the growth mechanisms of bilayer graphene on the outside surface of Cu enclosures at low pressures. We observed that the asymmetric growth environment of a Cu enclosure can yield a much higher (up to 100%) bilayer coverage on the outside surface as compared to the bilayer growth on a flat Cu foil, where both sides are exposed to the same growth environment. By simultaneously examining the graphene films grown on both the outside and inside surfaces of the Cu enclosure, we find that carbon can diffuse from the inside surface to the outside via exposed copper regions on the inside surface. The kinetics of this process are examined by coupling the asymmetric growth between the two surfaces through a carbon diffusion model. Finally, using these results, we show that the coverage of bilayer graphene can be tuned simply by changing the thickness of the Cu foil, further confirming our model of carbon delivery through the Cu foil.
C1 [Fang, Wenjing; Hsu, Allen L.; Song, Yi; Dresselhaus, Mildred S.; Palacios, Tomas; Kong, Jing] MIT, Dept Elect Engn & Comp Sci, Cambridge, MA 02139 USA.
[Dresselhaus, Mildred S.] MIT, Dept Phys, Cambridge, MA 02139 USA.
[Birdwell, Anthony G.; Amani, Matin; Dubey, Madan] US Army Res Lab, Adelphi, MD 20783 USA.
RP Kong, J (reprint author), MIT, Dept Elect Engn & Comp Sci, 77 Mass Ave, Cambridge, MA 02139 USA.
EM jingkong@mit.edu
FU National Science Foundation [NSF DMR 0845358]; Graphene Approaches to
Terahertz Electronics (GATE) Multidisciplinary University Research
Initiative (MURI) of Massachusetts Institute of Technology (MIT)-Harvard
University-Boston University through the Office of Naval Research (ONR);
Army Research Labs (ARL); [ONR-MURI-N00014-09-1-1063]
FX This work was partially supported by National Science Foundation under
award number NSF DMR 0845358 and the Graphene Approaches to Terahertz
Electronics (GATE) Multidisciplinary University Research Initiative
(MURI) of Massachusetts Institute of Technology (MIT)-Harvard
University-Boston University through the Office of Naval Research (ONR),
and the Army Research Labs (ARL). M.S.D. acknowledges
ONR-MURI-N00014-09-1-1063.
NR 36
TC 26
Z9 26
U1 12
U2 83
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 1936-0851
EI 1936-086X
J9 ACS NANO
JI ACS Nano
PD JUN
PY 2014
VL 8
IS 6
BP 6491
EP 6499
DI 10.1021/nn5015177
PG 9
WC Chemistry, Multidisciplinary; Chemistry, Physical; Nanoscience &
Nanotechnology; Materials Science, Multidisciplinary
SC Chemistry; Science & Technology - Other Topics; Materials Science
GA AK0FV
UT WOS:000338089200119
PM 24878354
ER
PT J
AU Yeap, EE
Morrison, JJ
Apodaca, AN
Egan, G
Jansen, JO
AF Yeap, E. E.
Morrison, J. J.
Apodaca, A. N.
Egan, G.
Jansen, J. O.
TI Trauma care in Scotland: effect of rurality on ambulance travel times
and level of destination healthcare facility
SO EUROPEAN JOURNAL OF TRAUMA AND EMERGENCY SURGERY
LA English
DT Article
DE Traumatology; Rurality; Trauma systems; Scotland
ID MORTALITY; URBAN
AB The aim of this study was to determine the effect of rurality on the level of destination healthcare facility and ambulance response times for trauma patients in Scotland.
We used a retrospective analysis of pre-hospital data routinely collected by the Scottish Ambulance Service from 2009-2010. Incident locations were categorised by rurality, using the Scottish urban/rural classification. The level of destination healthcare facility was coded as either a teaching hospital, large general hospital, general hospital, or other type of facility.
A total of 64,377 incidents met the inclusion criteria. The majority of incidents occurred in urban areas, which mostly resulted in admission to teaching hospitals. Incidents from other areas resulted in admission to a lower-level facility. The majority of incidents originating in very remote small towns and very remote rural areas were treated in a general hospital. Median call-out times and travel times increased with the degree of rurality, although with some exceptions.
Trauma is relatively rare in rural areas, but patients injured in remote locations are doubly disadvantaged by prolonged pre-hospital times and admission to a hospital that may not be adequately equipped to deal with their injuries. These problems may be overcome by the regionalisation of trauma care, and enhanced retrieval capability.
C1 [Yeap, E. E.] Aberdeen Royal Infirm, Aberdeen, Scotland.
[Morrison, J. J.] Royal Ctr Def Med, Acad Dept Mil Surg & Trauma, Birmingham, W Midlands, England.
[Morrison, J. J.] Glasgow Royal Infirm, Acad Surg Unit, Glasgow G4 0SF, Lanark, Scotland.
[Apodaca, A. N.] US Army Inst Surg Res, Ft Sam Houston, TX USA.
[Egan, G.] Scottish Ambulance Serv, Edinburgh, Midlothian, Scotland.
[Jansen, J. O.] Aberdeen Royal Infirm, Ward 34, Aberdeen, Scotland.
RP Yeap, EE (reprint author), Aberdeen Royal Infirm, Foresterhill, Aberdeen, Scotland.
EM eeemin@gmail.com; jan.jansen@nhs.net
NR 22
TC 0
Z9 0
U1 0
U2 3
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1863-9933
EI 1863-9941
J9 EUR J TRAUMA EMERG S
JI Eur. J. Trauma Emerg. Surg.
PD JUN
PY 2014
VL 40
IS 3
BP 295
EP 302
DI 10.1007/s00068-014-0383-x
PG 8
WC Emergency Medicine
SC Emergency Medicine
GA AK2CG
UT WOS:000338225900010
PM 26816063
ER
PT J
AU Biss, MM
McNesby, KL
AF Biss, Matthew M.
McNesby, Kevin L.
TI Optically measured explosive impulse
SO EXPERIMENTS IN FLUIDS
LA English
DT Article
ID CHARGES; ABEL
AB An experimental technique is investigated to optically measure the explosive impulse produced by laboratory-scale spherical charges detonated in air. Explosive impulse has historically been calculated from temporal pressure measurements obtained via piezoelectric transducers. The presented technique instead combines schlieren flow visualization and high-speed digital imaging to optically measure explosive impulse. Prior to an explosive event, schlieren system calibration is performed using known light-ray refractions and resulting digital image intensities. Explosive charges are detonated in the test section of a schlieren system and imaged by a high-speed digital camera in pseudo-streak mode. Spatiotemporal schlieren intensity maps are converted using an Abel deconvolution, Rankine-Hugoniot jump equations, ideal gas law, triangular temperature decay profile, and Schardin's standard photometric technique to yield spatiotemporal pressure maps. Temporal integration of individual pixel pressure profiles over the positive pressure duration of the shock wave yields the explosive impulse generated for a given radial standoff. Calculated explosive impulses are shown to exhibit good agreement between optically derived values and pencil gage pressure transducers.
C1 [Biss, Matthew M.; McNesby, Kevin L.] US Army Res Lab, Lethal Div, Energet Technol Branch, Aberdeen Proving Ground, MD 21005 USA.
RP Biss, MM (reprint author), US Army Res Lab, Lethal Div, Energet Technol Branch, Aberdeen Proving Ground, MD 21005 USA.
EM matthew.m.biss.civ@mail.mil
FU U.S. Army Research Laboratory's Lethality Division Innovation Program;
National Research Council Postdoctoral Fellowship Program
FX We would like to acknowledge the U.S. Army Research Laboratory's
Lethality Division Innovation Program and the National Research Council
Postdoctoral Fellowship Program for funding of this research. We would
like to acknowledge Mr. Roy Maulbetsch, Mr. Terry Piatt, and Mrs. Lori
Pridgeon of the Ingredient, Formulation, & Processing Team for pressing
of the energetic samples and Mr. Richard Benjamin, Mr. William Sickels,
Mr. Ray Sparks, Mr. Gene Summers, and Mr. Ronnie Thompson of the
Detonation Science Team for their assistance in conducting these
experiments, and Ms. Susan Corley at DSC Laboratories for providing the
linearly graded filters. Lastly, we would like to acknowledge Dr.
Michael Hargather at New Mexico Tech for his thoughtful discussions and
insight.
NR 20
TC 1
Z9 1
U1 3
U2 18
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0723-4864
EI 1432-1114
J9 EXP FLUIDS
JI Exp. Fluids
PD JUN
PY 2014
VL 55
IS 6
AR 1749
DI 10.1007/s00348-014-1749-x
PG 8
WC Engineering, Mechanical; Mechanics
SC Engineering; Mechanics
GA AK3KL
UT WOS:000338322400013
ER
PT J
AU Britzke, ER
Gumbert, MW
Hohmann, MG
AF Britzke, Eric R.
Gumbert, Mark W.
Hohmann, Matthew G.
TI Behavioral Response of Bats to Passive Integrated Transponder Tag Reader
Arrays Placed at Cave Entrances
SO JOURNAL OF FISH AND WILDLIFE MANAGEMENT
LA English
DT Article
DE bats; Indiana bat; behavior; passive integrated transponder (PIT) tags
ID ROOSTS
AB An increasingly popular mark-recapture method to study the ecology of bats is the use of passive integrated transponder (PIT) tags. Deployment of PIT reader arrays at entrances to caves and mines can yield insight into bat behavior during swarming, winter activity, and emergence. This application has the potential to address questions about bat activity at cave and mine entrances in response to white-nose syndrome or bat seasonal movements; however, no studies have examined the response of bats to these arrays. We describe bat response to placement of PIT tag reader arrays using camcorders and supplemental infrared illuminators at three cave entrances near Bloomington, Indiana, during spring 2006. A random subset of 5-min periods was viewed and bat behavior was classified. Circling represented >70% of all behavior noted for two caves but only represented approximately 30% of behavior at the third cave. Proportions of observed activity that resulted in contacts or landings were consistently low across the three caves ((x) over bar = 1.34%; range 0.5-3.0%), with most contacts causing bats to simply change course and fly away. Based on our observations, positioning reader PIT tag reader arrays at cave entrances to passively recapture PIT tags does not limit bat movements. However, video monitoring during initial sampling efforts of future projects should be conducted to verify appropriate placement and configuration of PIT tag reader arrays. This research provides data illustrating the lack of significant impact in using PIT tag reader arrays at cave entrances, thereby opening up the potential use of this technology to address issues of bats ecology that cannot be obtained with other marking techniques.
C1 [Britzke, Eric R.] US Army, Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA.
[Gumbert, Mark W.] Copperhead Environm Consulting Inc, Paint Lick, KY 40461 USA.
[Hohmann, Matthew G.] US Army, Engineer Res & Dev Ctr, Construct Engn Res Lab, Champaign, IL 61826 USA.
RP Britzke, ER (reprint author), US Army, Engineer Res & Dev Ctr, Environm Lab, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA.
EM Eric.R.Britzke@usace.army.mil
FU U.S. Army Corps of Engineers, Construction Engineering Research
Laboratory
FX The U.S. Army Corps of Engineers, Construction Engineering Research
Laboratory provided financial and technical support for this project. C.
Hansen designed the supplemental power system for the digital readers
and fitted the weatherproof cases with external recharging connectors.
P. Frank assisted in the construction of the PIT tag reader arrays. S.
Johnson provided invaluable assistance with cave selection, contacting
property owners, and PIT tag reader array placement. L. Pruitt and A.
King provided guidance on project implementation. D. Everton, K. Dunlap,
M. Wright, and M. Lawrence provided cave access. D. Foster, J. Hawkins,
C. Leftwich, K. McDonald, P. Roby, and P. Sewell were instrumental in
transporting the heavy equipment allowing for data collection for this
project. P. Roby and N. Beane, three anonymous reviewers, and the
Subject Editor provided constructive comments on an earlier version of
this manuscript.
NR 15
TC 1
Z9 1
U1 2
U2 36
PU U S FISH & WILDLIFE SERVICE
PI SHEPHERDSTOWN
PA NATL CONSERVATION TRAINING CENTER, CONSERVATION LIBRARY, 698
CONSERVATION WAY, SHEPHERDSTOWN, WV 25443 USA
SN 1944-687X
J9 J FISH WILDL MANAG
JI J. Fish Wildl. Manag.
PD JUN
PY 2014
VL 5
IS 1
BP 146
EP 150
DI 10.3996/082012-JFWM-065
PG 5
WC Biodiversity Conservation; Ecology
SC Biodiversity & Conservation; Environmental Sciences & Ecology
GA AK5AT
UT WOS:000338436900015
ER
PT J
AU Chung, DH
Jonsson, CB
Tower, NA
Chu, YK
Sahin, E
Golden, JE
Noah, JW
Schroeder, CE
Sotsky, JB
Sosa, MI
Cramer, DE
McKellip, SN
Rasmussen, L
White, EL
Schmaljohn, CS
Julander, JG
Smith, JM
Filone, CM
Connor, JH
Sakurai, Y
Davey, RA
AF Chung, Dong-Hoon
Jonsson, Colleen B.
Tower, Nichole A.
Chu, Yong-Kyu
Sahin, Ergin
Golden, Jennifer E.
Noah, James W.
Schroeder, Chad E.
Sotsky, Julie B.
Sosa, Melinda I.
Cramer, Daniel E.
McKellip, Sara N.
Rasmussen, Lynn
White, E. Lucile
Schmaljohn, Connie S.
Julander, Justin G.
Smith, Jeffrey M.
Filone, Claire Marie
Connor, John H.
Sakurai, Yasuteru
Davey, Robert A.
TI Discovery of a Novel Compound with Anti-Venezuelan Equine Encephalitis
Virus Activity That Targets the Nonstructural Protein 2
SO PLOS PATHOGENS
LA English
DT Article
ID SEMLIKI-FOREST-VIRUS; RESPIRATORY SYNCYTIAL VIRUS; ENCEPHALOMYELITIS
VIRUS; NSP2 PROTEASE; VACCINES; CELLS; DERIVATIVES; POLYMERASE;
MUTATIONS; INFECTION
AB Alphaviruses present serious health threats as emerging and re-emerging viruses. Venezuelan equine encephalitis virus (VEEV), a New World alphavirus, can cause encephalitis in humans and horses, but there are no therapeutics for treatment. To date, compounds reported as anti-VEEV or anti-alphavirus inhibitors have shown moderate activity. To discover new classes of anti-VEEV inhibitors with novel viral targets, we used a high-throughput screen based on the measurement of cell protection from live VEEV TC-83-induced cytopathic effect to screen a 340,000 compound library. Of those, we identified five novel anti-VEEV compounds and chose a quinazolinone compound, CID15997213 (IC50 = 0.84 mu M), for further characterization. The antiviral effect of CID15997213 was alphavirus-specific, inhibiting VEEV and Western equine encephalitis virus, but not Eastern equine encephalitis virus. In vitro assays confirmed inhibition of viral RNA, protein, and progeny synthesis. No antiviral activity was detected against a select group of RNA viruses. We found mutations conferring the resistance to the compound in the N-terminal domain of nsP2 and confirmed the target residues using a reverse genetic approach. Time of addition studies showed that the compound inhibits the middle stage of replication when viral genome replication is most active. In mice, the compound showed complete protection from lethal VEEV disease at 50 mg/kg/day. Collectively, these results reveal a potent anti-VEEV compound that uniquely targets the viral nsP2 N-terminal domain. While the function of nsP2 has yet to be characterized, our studies suggest that the protein might play a critical role in viral replication, and further, may represent an innovative opportunity to develop therapeutic interventions for alphavirus infection.
C1 [Chung, Dong-Hoon; Jonsson, Colleen B.; Sahin, Ergin] Univ Louisville, Dept Microbiol, Louisville, KY 40292 USA.
[Chung, Dong-Hoon; Jonsson, Colleen B.; Sahin, Ergin] Univ Louisville, Dept Immunol, Louisville, KY 40292 USA.
[Chung, Dong-Hoon; Jonsson, Colleen B.; Chu, Yong-Kyu; Sahin, Ergin; Sotsky, Julie B.; Cramer, Daniel E.] Univ Louisville, Ctr Predict Med Biodef & Emerging Infect Dis, Louisville, KY 40292 USA.
[Jonsson, Colleen B.] Univ Louisville, Dept Pharmacol & Toxicol, Louisville, KY USA.
[Tower, Nichole A.; Noah, James W.; Sosa, Melinda I.; McKellip, Sara N.; Rasmussen, Lynn; White, E. Lucile] So Res Inst, Drug Discovery Dept, Birmingham, AL 35255 USA.
[Golden, Jennifer E.; Schroeder, Chad E.] Univ Kansas, Specialized Chem Ctr, Lawrence, KS 66045 USA.
[Schmaljohn, Connie S.; Smith, Jeffrey M.] US Army Med Res Inst Infect Dis, Ft Detrick, MD USA.
[Julander, Justin G.] Utah State Univ, Inst Antiviral Res, Logan, UT 84322 USA.
[Filone, Claire Marie; Connor, John H.] Boston Univ, Boston, MA 02215 USA.
[Sakurai, Yasuteru; Davey, Robert A.] Texas Biomed Res Inst, San Antonio, TX USA.
RP Chung, DH (reprint author), Univ Louisville, Dept Microbiol, Louisville, KY 40292 USA.
EM dhchun01@louisville.edu
OI Connor, John/0000-0002-8867-7256; Golden, Jennifer/0000-0002-6813-3710
FU NIH [R03MH087448-01A1]; University of Louisville Internal Research
Initiate; USAMRAA [W81XWH-10-2-0064, W81XWH-08-2-0024]
FX This research was supported by the following funding sources: NIH
R03MH087448-01A1, University of Louisville Internal Research Initiate
grant to DHC, USAMRAA W81XWH-10-2-0064 and W81XWH-08-2-0024 to CBJ.
Screening was provided by the Southern Research Specialized Screening
Center (U54HG005034-0) and chemistry through the University of Kansas
Specialized Chemistry Center (U54HG005031). The funders had no role in
study design, data collection and analysis, decision to publish, or
preparation of the manuscript.
NR 36
TC 9
Z9 9
U1 0
U2 5
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1553-7366
EI 1553-7374
J9 PLOS PATHOG
JI PLoS Pathog.
PD JUN
PY 2014
VL 10
IS 6
AR e1004213
DI 10.1371/journal.ppat.1004213
PG 10
WC Microbiology; Parasitology; Virology
SC Microbiology; Parasitology; Virology
GA AK1SV
UT WOS:000338197400046
PM 24967809
ER
PT J
AU Walsh, ME
Walsh, MR
Collins, CM
Racine, CH
AF Walsh, Marianne E.
Walsh, Michael R.
Collins, Charles M.
Racine, Charles H.
TI White Phosphorus Contamination of an Active Army Training Range
SO WATER AIR AND SOIL POLLUTION
LA English
DT Article
DE White phosphorus; Ordnance; Remediation; Military training; Waterfowl
mortality; Sampling
ID SALT-MARSH; REMEDIATION; SEDIMENTS; DUCKS; P-4
AB Detonations of military ordnance will leave various amounts of chemical residue on training ranges. Significant adverse ecological effects from these residues have not been documented except for ordnance containing white phosphorus. At a military training range in Alaska, USA, the deaths of thousands of waterfowl due to poisoning from white phosphorus ordnance prompted a two-decade-long investigation of the extent of the contamination, remediation technologies, and methods to assess and monitor the effectiveness of the remediation. This paper gives an overview of these investigations and provides the outcome of the remediation efforts.
C1 [Walsh, Marianne E.; Walsh, Michael R.; Collins, Charles M.; Racine, Charles H.] US Army Cold Reg Res & Engn Lab, Hanover, NH 03755 USA.
RP Walsh, ME (reprint author), US Army Cold Reg Res & Engn Lab, 72 Lyme Rd, Hanover, NH 03755 USA.
EM marianne.e.walsh@usace.army.mil
NR 25
TC 1
Z9 1
U1 0
U2 4
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0049-6979
EI 1573-2932
J9 WATER AIR SOIL POLL
JI Water Air Soil Pollut.
PD JUN
PY 2014
VL 225
IS 6
AR 2001
DI 10.1007/s11270-014-2001-2
PG 11
WC Environmental Sciences; Meteorology & Atmospheric Sciences; Water
Resources
SC Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences;
Water Resources
GA AK3ON
UT WOS:000338334200035
ER
PT J
AU Mehta, N
Oyler, K
Cheng, G
Shah, A
Marin, J
Yee, K
AF Mehta, Neha
Oyler, Karl
Cheng, Gartung
Shah, Akash
Marin, John
Yee, Kin
TI Primary Explosives
SO ZEITSCHRIFT FUR ANORGANISCHE UND ALLGEMEINE CHEMIE
LA English
DT Article
DE Energetic materials; "Green" explosives; Primary explosives; DBX-1; Lead
ID DBX-1
AB Primary explosives, unlike secondary explosives, show a very rapid transition from combustion (or deflagration) to detonation and are considerably sensitive to small stimuli, such as impact, friction, electrostatic discharge, and heat. Primary explosives generate either a large amount of heat or a shockwave, which makes the transfer of the detonation to a less sensitive propellant or secondary explosive possible.[1] Primary explosives are key components in detonators and primers, which are the initiating elements to many military items such as small, medium, and large caliber munitions, mortars, artillery, warheads, etc. The two most common military primary explosives are lead azide and lead styphnate. Lead based compounds such as these have well-established hazards to health and the environment. To overcome these concerns, in common U. S. Army detonators and primers lead azide was replaced with DBX-1 [copper(I) nitrotetrazolate], recently developed by Pacific Scientific Energetic Materials Company and the U. S. Naval Surface Warfare Center at Indian Head. Further, in order to minimize the dangers to personnel and equipment associated with synthesizing and handling primary explosives, a dedicated, remote-operated facility for the synthesis and testing of primary explosives has been developed.
C1 [Mehta, Neha; Oyler, Karl; Cheng, Gartung; Shah, Akash; Marin, John; Yee, Kin] US Army RDECOM ARDEC, Explos Dev Branch, Picatinny Arsenal, NJ 07806 USA.
RP Mehta, N (reprint author), US Army RDECOM ARDEC, Explos Dev Branch, Picatinny Arsenal, NJ 07806 USA.
EM neha.mehta.civ@mail.mil
FU RDECOM Environmental Quality Technology Ordnance Environmental Program;
PM-JS
FX We would like to acknowledge RDECOM Environmental Quality Technology
Ordnance Environmental Program and PM-JS for their funding support. We
would also like to thank Franklin Engineering, especially Charlie
Sturdivant, for his patience in designing the automated systems. Also
like to thank Thomas M. Klapotke and his team and Jerry Salan of Nalas
Engineering.
NR 10
TC 7
Z9 7
U1 5
U2 18
PU WILEY-V C H VERLAG GMBH
PI WEINHEIM
PA BOSCHSTRASSE 12, D-69469 WEINHEIM, GERMANY
SN 0044-2313
EI 1521-3749
J9 Z ANORG ALLG CHEM
JI Z. Anorg. Allg. Chem.
PD JUN
PY 2014
VL 640
IS 7
SI SI
BP 1309
EP 1313
DI 10.1002/zaac.201400053
PG 5
WC Chemistry, Inorganic & Nuclear
SC Chemistry
GA AJ5RW
UT WOS:000337746000013
ER
PT J
AU Drost, RJ
Sadler, BM
AF Drost, Robert J.
Sadler, Brian M.
TI Constellation Design for Channel Precompensation in Multi-Wavelength
Visible Light Communications
SO IEEE TRANSACTIONS ON COMMUNICATIONS
LA English
DT Article
DE Channel precompensation; constellation design; modulation; visible-light
communications (VLC)
ID EMITTING-DIODES; DISCRETE MULTITONE; MODULATION; SYSTEM
AB The predicted ubiquity of light-emitting diodes (LEDs) suggests great potential for dual-use systems with visible light communications (VLC) capabilities. One class of LEDs employs multiple emitters at different wavelengths, making them appropriate for applications requiring colored output and providing multiple channels for communication. We present a design framework for optimizing the signaling constellation of VLC systems employing an arbitrary number of such LEDs, each with an arbitrary number of emitters. In particular, by considering the design of constellation-symbol locations jointly across LED emitters, the framework provides for the precompensation of linear channel distortions arising from, for example, cross-channel leakage, noise correlation, or wavelength-dependent received-signal and/or noise power, as well as the incorporation of design constraints for color-shift keying, dimming, and/or perceived color. Simulation results demonstrate the design approach and the potential performance enhancement that can be achieved for particular system scenarios. Experimental measurements using a prototype VLC system confirm such performance enhancements, providing real-world evidence of the benefit of applying the proposed framework to VLC channel precompensation.
C1 [Drost, Robert J.; Sadler, Brian M.] US Army Res Lab, Adelphi, MD 20783 USA.
RP Drost, RJ (reprint author), US Army Res Lab, Adelphi, MD 20783 USA.
EM robert.j.drost6.civ@mail.mil; brian.m.sadler6.civ@mail.mil
NR 37
TC 10
Z9 10
U1 0
U2 8
PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
PI PISCATAWAY
PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA
SN 0090-6778
EI 1558-0857
J9 IEEE T COMMUN
JI IEEE Trans. Commun.
PD JUN
PY 2014
VL 62
IS 6
BP 1995
EP 2005
DI 10.1109/TCOMM.2014.2321402
PG 11
WC Engineering, Electrical & Electronic; Telecommunications
SC Engineering; Telecommunications
GA AJ9KN
UT WOS:000338029200020
ER
PT J
AU Morelli, F
Neugebauer, JM
LaFiandra, ME
Burcham, P
Gordon, CT
AF Morelli, Frank
Neugebauer, Jennifer M.
LaFiandra, Michael E.
Burcham, Patricia
Gordon, Caleb T.
TI Recoil Measurement, Mitigation Techniques, and Effects on Small Arms
Weapon Design and Marksmanship Performance
SO IEEE TRANSACTIONS ON HUMAN-MACHINE SYSTEMS
LA English
DT Article
DE Accelerometers; anthropometry; force measurement; human factors;
interactive systems; motion measurement; test equipment
ID MAGNETO RHEOLOGICAL DAMPERS
AB A methodology to determine the interactive effects of weapon recoil, for both the weapon and the shooter in synchrony during shoulder-fired small arms target engagement scenarios, is yet to be established with widespread applications. Recoil energy can be measured using devices such as instrumented weapon mounts, or calculated from factors such as weapon weight, center of mass, projectile mass, and muzzle velocity. However, the effect of recoil on the shooter will affect shooting performance. Perceived recoil may be defined as a mental representation of the impact intensity experienced by the shooter, a subjective estimation that encompasses pain, discomfort, propensity to flinch, and other factors. Methods to quantify and mitigate the recoil energy experienced by the shooter, as well as proposed concepts for improved recording of the interaction between the physical and psychological correlates of recoil as it relates to small arms shoulder-fired weapon use are discussed.
C1 [Morelli, Frank; Neugebauer, Jennifer M.; LaFiandra, Michael E.; Burcham, Patricia; Gordon, Caleb T.] US Army Res Lab, Adelphi, MD 20783 USA.
RP Morelli, F (reprint author), US Army Res Lab, Adelphi, MD 20783 USA.
EM frank.morelli.civ@mail.mil; jennifer.neugebauer.ctr@mail.mil;
michael.e.lafiandra.civ@mail.mil; patricia.m.burcham.civ@mail.mil;
caleb.t.gordon.ctr@us.army.mil
NR 26
TC 2
Z9 2
U1 3
U2 8
PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
PI PISCATAWAY
PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA
SN 2168-2291
EI 2168-2305
J9 IEEE T HUM-MACH SYST
JI IEEE T. Hum.-Mach. Syst.
PD JUN
PY 2014
VL 44
IS 3
BP 422
EP 428
DI 10.1109/THMS.2014.2301715
PG 7
WC Computer Science, Artificial Intelligence; Computer Science, Cybernetics
SC Computer Science
GA AJ8NE
UT WOS:000337961300012
ER
PT J
AU Han, SC
Castro, F
Lee, LO
Charney, ME
Marx, BP
Brailey, K
Proctor, SP
Vasterling, JJ
AF Han, Sohyun C.
Castro, Frank
Lee, Lewina O.
Charney, Meredith E.
Marx, Brian P.
Brailey, Kevin
Proctor, Susan P.
Vasterling, Jennifer J.
TI Military unit support, postdeployment social support, and PTSD symptoms
among active duty and National Guard soldiers deployed to Iraq
SO JOURNAL OF ANXIETY DISORDERS
LA English
DT Article
DE Social support; Unit support; Posttraumatic stress disorder; Military
personnel; Deployment; Longitudinal
ID POSTTRAUMATIC-STRESS-DISORDER; MENTAL-HEALTH PROBLEMS; RISK-FACTORS;
LIFE EVENTS; RESILIENCE; PERSONNEL; VETERANS; EXPLANATIONS; AFGHANISTAN;
EXPERIENCES
AB Research suggests that military unit support and community postdeployment social support are associated with fewer PTSD symptoms following military deployment. This study extended prior research by examining the associations among predeployment unit support and PTSD symptoms before Iraq deployment as well as unit support, PTSD symptoms, and postdeployment social support after deployment among 835 U.S. Army and 173 National Guard soldiers. Multiple regression analyses indicated that predeployment unit support was not significantly associated with postdeployment PTSD severity in either group of soldiers, whereas higher unit support during deployment was significantly associated with lower postdeployment PTSD severity among active duty soldiers only. Among both groups, higher levels of postdeployment social support were associated with lower levels of postdeployment PTSD symptom severity. These findings suggest that postdeployment social support is a particularly strong buffer against postdeployment PTSD symptoms among both groups of soldiers whereas the effects of unit support may be limited. (C) 2014 Elsevier Ltd. All rights reserved.
C1 [Han, Sohyun C.; Castro, Frank; Lee, Lewina O.; Marx, Brian P.; Proctor, Susan P.; Vasterling, Jennifer J.] VA Boston Healthcare Syst, Natl Ctr PTSD, Boston, MA 02130 USA.
[Charney, Meredith E.; Brailey, Kevin] VA Boston Healthcare Syst, Boston, MA 02130 USA.
[Lee, Lewina O.; Marx, Brian P.; Brailey, Kevin; Vasterling, Jennifer J.] Boston Univ, Sch Med, Boston, MA 02118 USA.
[Proctor, Susan P.] US Army Res Inst Environm Med, Natick, MA USA.
[Lee, Lewina O.; Proctor, Susan P.] Boston Univ, Sch Publ Hlth, Boston, MA 02118 USA.
RP Vasterling, JJ (reprint author), VA Boston Healthcare Syst 116B 4, 150 South Huntington Ave, Boston, MA 02130 USA.
EM jennifer.vasterling@va.gov
FU NIA NIH HHS [AG032037, AG039343]
NR 31
TC 6
Z9 6
U1 3
U2 18
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0887-6185
EI 1873-7897
J9 J ANXIETY DISORD
JI J. Anxiety Disord.
PD JUN
PY 2014
VL 28
IS 5
BP 446
EP 453
DI 10.1016/j.janxdis.2014.04.004
PG 8
WC Psychology, Clinical; Psychiatry
SC Psychology; Psychiatry
GA AJ8WS
UT WOS:000337989400003
PM 24846492
ER
PT J
AU Jones, KF
Thompson, G
Claffey, KJ
Kelsey, EP
AF Jones, Kathleen F.
Thompson, Gregory
Claffey, Keran J.
Kelsey, Eric P.
TI Gamma Distribution Parameters for Cloud Drop Distributions from
Multicylinder Measurements
SO JOURNAL OF APPLIED METEOROLOGY AND CLIMATOLOGY
LA English
DT Article
ID PART I; MICROPHYSICS PARAMETERIZATION; EXPLICIT FORECASTS
AB The liquid water content and drop diameters in supercooled clouds have been measured since the 1940s at the summit of Mount Washington in New Hampshire using a rotating multicylinder. Many of the cloud microphysics models in the Weather Research and Forecasting Model (WRF) assume a gamma distribution for cloud drops. In this paper, years of multicylinder data are reanalyzed to determine the best-fitting gamma or monodisperse distribution to compare with parameters in the WRF cloud models. The single-moment cloud schemes specify a predetermined and constant drop number density in clouds, which leads to a fixed relationship between the median volume drop diameter and the liquid water content. The Mount Washington drop number densities are generally larger and best-fit distributions are generally narrower than is typically assumed in WRF.
C1 [Jones, Kathleen F.; Claffey, Keran J.] US Army, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA.
[Thompson, Gregory] Natl Ctr Atmospher Res, Boulder, CO 80307 USA.
[Kelsey, Eric P.] Mt Washington Observ, North Conway, NH USA.
RP Jones, KF (reprint author), US Army, Cold Reg Res & Engn Lab, Terr & Cryospher Sci Branch, 72 Lyme Rd, Hanover, NH 03755 USA.
EM kathleen.f.jones@usace.army.mil
FU U.S. Army Corps of Engineers Engineer Research and Development Center
Geospatial Research and Engineering business area work unit "Geoenabled
Multimodal Situational Awareness"; Plymouth State University
FX Authors Jones and Claffey were supported by the U.S. Army Corps of
Engineers Engineer Research and Development Center Geospatial Research
and Engineering business area work unit "Geoenabled Multimodal
Situational Awareness" and a Cooperative Research and Development
Agreement with Plymouth State University. We thank the anonymous
reviewers for their useful suggestions.
NR 17
TC 1
Z9 1
U1 1
U2 6
PU AMER METEOROLOGICAL SOC
PI BOSTON
PA 45 BEACON ST, BOSTON, MA 02108-3693 USA
SN 1558-8424
EI 1558-8432
J9 J APPL METEOROL CLIM
JI J. Appl. Meteorol. Climatol.
PD JUN
PY 2014
VL 53
IS 6
BP 1606
EP 1617
DI 10.1175/JAMC-D-13-0306.1
PG 12
WC Meteorology & Atmospheric Sciences
SC Meteorology & Atmospheric Sciences
GA AJ5YT
UT WOS:000337767400017
ER
PT J
AU Poropatich, RK
Pavliscsak, HH
Tong, JC
Little, JR
McVeigh, FL
AF Poropatich, Ronald K.
Pavliscsak, Holly H.
Tong, James C.
Little, Jeanette R.
McVeigh, Francis L.
TI mCare: Using Secure Mobile Technology to Support Soldier Reintegration
and Rehabilitation
SO TELEMEDICINE AND E-HEALTH
LA English
DT Article
DE health; military medicine; information management; rehabilitation;
telecommunications
ID TRAUMATIC BRAIN-INJURY
AB Background: The U. S. Army Medical Department conducted a pilot mobile health project to determine the requirements for coordination of care for "Wounded Warriors'' using mobile messaging. The primary objective was to determine if a secure mobile health (mhealth) intervention provided to geographically dispersed patients would improve contact rates and positively impact the military healthcare system. Methods and Materials: Over 21 months, volunteers enrolled in a Health Insurance Portability and Accountability Act-compliant, secure mobile messaging initiative called mCare. The study included males and females, 18-61 years old, with a minimum of 60 days of outpatient recovery. Volunteers were required to have a compatible phone. The mhealth intervention included appointment reminders, health and wellness tips, announcements, and other relevant information to this population exchanged between care teams and patients. Results: Provider respondents reported that 85% would refer patients to mCare, and 56% noted improvement in appointment attendance (n = 90). Patient responses also revealed high acceptability of mCare and refined the frequency and delivery times (n = 114). The pilot project resulted in over 84,000 outbound messages and improved contact rates by 176%. Conclusions: The mCare pilot project demonstrated the feasibility and administrative effectiveness of a scalable mhealth application using secure mobile messaging and information exchanges, including personalized patient education.
C1 [Poropatich, Ronald K.] Univ Pittsburgh, Ctr Mil Med Res, Pittsburgh, PA USA.
[Pavliscsak, Holly H.; Little, Jeanette R.] US Army Med Res & Mat Command USAMRMC, Telemed & Adv Technol Res Ctr TATRC, Ft Gordon, GA 30905 USA.
[Tong, James C.] PricewaterhouseCoopers LLP, Herndon, VA USA.
[McVeigh, Francis L.] US Army Med Res & Mat Command, Telemed & Adv Technol Ctr, Ft Detrick, MD USA.
RP Pavliscsak, HH (reprint author), US Army Med Res & Mat Command USAMRMC, Mobile Hlth Innovat Ctr MHIC, Telemed & Adv Technol Res Ctr TATRC, mCare Project, Bldg 38711, Ft Gordon, GA 30905 USA.
EM holly.h.pavliscsak.ctr@mail.mil
NR 15
TC 3
Z9 3
U1 1
U2 12
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1530-5627
EI 1556-3669
J9 TELEMED E-HEALTH
JI Telemed. e-Health
PD JUN
PY 2014
VL 20
IS 6
BP 563
EP 569
DI 10.1089/tmj.2013.0226
PG 7
WC Health Care Sciences & Services
SC Health Care Sciences & Services
GA AJ8IA
UT WOS:000337945500010
PM 24666038
ER
PT J
AU Pissani, F
Streeck, H
AF Pissani, Franco
Streeck, Hendrik
TI Emerging concepts on T follicular helper cell dynamics in HIV infection
SO TRENDS IN IMMUNOLOGY
LA English
DT Review
DE follicular B helper T cell; HIV; HIV neutralizing antibody; broadly
neutralizing antibody; peripheral blood T follicular helper T cell
(pTfh); vaccine T follicular helper cells
ID CHRONIC VIRAL-INFECTION; CENTER B-CELL; LIVED PLASMA-CELLS; GERMINAL
CENTER; NEUTRALIZING ANTIBODIES; MONOCLONAL-ANTIBODIES; C-MAF;
RESPONSES; VIRUS; BROAD
AB Inducing cross-reactive broadly neutralizing antibody (bNAb) responses to HIV through vaccination remains an insurmountable challenge. T follicular helper (T-FH) cells are fundamental for the development of antigen-specific antibody responses and therefore crucial for anti-HIV vaccine design. Here, we review recent studies supporting an intricate involvement of T-FH cells in HIV pathogenesis and bNAb development during HIV infection. We also examine emerging data suggesting that T-FH cell responses may be traceable in peripheral blood, and discuss the implications of these findings in the context of vaccine design and future research in T-FH cell immunobiology.
C1 [Pissani, Franco; Streeck, Hendrik] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD 20910 USA.
[Pissani, Franco; Streeck, Hendrik] Henry M Jackson Fdn Adv Mil Med, Bethesda, MD USA.
RP Streeck, H (reprint author), Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD 20910 USA.
EM hstreeck@hivresearch.org
FU US National Institutes of Health (NIH) [R01 AI091450-01, R01
AI094602-01]; U.S. Department of Defense (DOD); [W81XWH-07-2-0067]
FX We apologize to those whose work is not mentioned in this review due to
space limitations. This study was funded by the US National Institutes
of Health (NIH) (R01 AI091450-01 and R01 AI094602-01) and a cooperative
agreement (W81XWH-07-2-0067) between the Henry M. Jackson Foundation for
the Advancement of Military Medicine, Inc., and the U.S. Department of
Defense (DOD).
NR 78
TC 11
Z9 12
U1 1
U2 12
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1471-4906
EI 1471-4981
J9 TRENDS IMMUNOL
JI Trends Immunol.
PD JUN
PY 2014
VL 35
IS 6
BP 278
EP 286
DI 10.1016/j.it.2014.02.010
PG 9
WC Immunology
SC Immunology
GA AJ7MO
UT WOS:000337881000007
PM 24703588
ER
PT J
AU Cooper, C
Sutorik, AC
Wright, J
Luoto, EA
Gilde, G
Wolfenstine, J
AF Cooper, Christopher
Sutorik, Anthony C.
Wright, Jared
Luoto, E. Arthur, III
Gilde, Gary
Wolfenstine, Jeff
TI Mechanical Properties of Hot Isostatically Pressed Li0.35La0.55TiO3
SO ADVANCED ENGINEERING MATERIALS
LA English
DT Article
ID LITHIUM LANTHANUM TITANATES; IONIC-CONDUCTIVITY; AIR BATTERIES;
SOLID-STATE; LI-AIR; ELECTROLYTE; CERAMICS; LI0.33LA0.57TIO3
C1 [Cooper, Christopher; Sutorik, Anthony C.; Wright, Jared; Luoto, E. Arthur, III; Gilde, Gary] US Army Res Lab, RDRL WMM E, Aberdeen Proving Ground, MD 21005 USA.
[Wolfenstine, Jeff] US Army Res Lab, RDRL SED C, Adelphi, MD 20783 USA.
RP Cooper, C (reprint author), US Army Res Lab, RDRL WMM E, Bldg 4600, Aberdeen Proving Ground, MD 21005 USA.
EM jeffrey.b.wolfenstine.civ@mail.mil
NR 25
TC 1
Z9 1
U1 5
U2 28
PU WILEY-V C H VERLAG GMBH
PI WEINHEIM
PA BOSCHSTRASSE 12, D-69469 WEINHEIM, GERMANY
SN 1438-1656
EI 1527-2648
J9 ADV ENG MATER
JI Adv. Eng. Mater.
PD JUN
PY 2014
VL 16
IS 6
SI SI
BP 755
EP 759
DI 10.1002/adem.201400071
PG 5
WC Materials Science, Multidisciplinary
SC Materials Science
GA AJ4HQ
UT WOS:000337635500011
ER
PT J
AU Pugh, C
Keasey, S
Korman, L
Pittman, PR
Ulrich, RG
AF Pugh, Christine
Keasey, Sarah
Korman, Lawrence
Pittman, Phillip R.
Ulrich, Robert G.
TI Human Antibody Responses to the Polyclonal Dryvax Vaccine for Smallpox
Prevention Can Be Distinguished from Responses to the Monoclonal
Replacement Vaccine ACAM2000
SO CLINICAL AND VACCINE IMMUNOLOGY
LA English
DT Article
ID POXVIRUS ORTHOLOGOUS CLUSTERS; SURFACE HEPARAN-SULFATE; HUMAN
IMMUNE-RESPONSE; SINGLE-STRANDED-DNA; 2 INFECTIOUS FORMS; INTRACELLULAR
MATURE; CELL-SURFACE; VIRUS ENVELOPE; BINDING-PROTEIN; EXTRACELLULAR
DOMAIN
AB Dryvax (Wyeth Laboratories, Inc., Marietta, PA) is representative of the vaccinia virus preparations that were previously used for preventing smallpox. While Dryvax was highly effective, the national supply stocks were depleted, and there were manufacturing concerns regarding sterility and the clonal heterogeneity of the vaccine. ACAM2000 (Acambis, Inc./Sanofi-Pasteur Biologics Co., Cambridge, MA), a single-plaque-purified vaccinia virus derivative of Dryvax, recently replaced the polyclonal smallpox vaccine for use in the United States. A substantial amount of sequence heterogeneity exists within the polyclonal proteome of Dryvax, including proteins that are missing from ACAM2000. Reasoning that a detailed comparison of antibody responses to the polyclonal and monoclonal vaccines may be useful for identifying unique properties of each antibody response, we utilized a protein microarray comprised of approximately 94% of the vaccinia poxvirus proteome (245 proteins) to measure protein-specific antibody responses of 71 individuals receiving a single vaccination with ACAM2000 or Dryvax. We observed robust antibody responses to 21 poxvirus proteins in vaccinated individuals, including 11 proteins that distinguished Dryvax responses from ACAM2000. Analysis of protein sequences from Dryvax clones revealed amino acid level differences in these 11 antigenic proteins and suggested that sequence variation and clonal heterogeneity may contribute to the observed differences between Dryvax and ACAM2000 antibody responses.
C1 [Pugh, Christine; Keasey, Sarah; Korman, Lawrence; Pittman, Phillip R.; Ulrich, Robert G.] US Army Med Res Inst Infect Dis, Frederick, MD 21702 USA.
RP Ulrich, RG (reprint author), US Army Med Res Inst Infect Dis, Frederick, MD 21702 USA.
EM rulrich@bhsai.org
FU Military Vaccine Agency, Office of the Surgeon General, United States
Army; Student Research Participation Program at the U.S. Army Medical
Research Institute of Infectious Disease
FX This research was supported in part by an appointment of C.P. and S.K.
to the Student Research Participation Program at the U.S. Army Medical
Research Institute of Infectious Disease administered by Oak Ridge
Institute for Science and Education through an interagency agreement
between the U.S. Department of Energy and USAMRMC. This clinical study
was sponsored by the Military Vaccine Agency, Office of the Surgeon
General, United States Army.
NR 89
TC 2
Z9 2
U1 3
U2 9
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 1556-6811
EI 1556-679X
J9 CLIN VACCINE IMMUNOL
JI Clin. Vaccine Immunol.
PD JUN
PY 2014
VL 21
IS 6
BP 877
EP 885
DI 10.1128/CVI.00035-14
PG 9
WC Immunology; Infectious Diseases; Microbiology
SC Immunology; Infectious Diseases; Microbiology
GA AJ0NW
UT WOS:000337352500014
PM 24759651
ER
PT J
AU Shaffer, D
Hughes, MD
Sawe, F
Bao, YJ
Moses, A
Hogg, E
Lockman, S
Currier, J
AF Shaffer, Douglas
Hughes, Michael D.
Sawe, Fredrick
Bao, Yajing
Moses, Agnes
Hogg, Evelyn
Lockman, Shahin
Currier, Judith
TI Cardiovascular Disease Risk Factors in HIV-Infected Women After
Initiation of Lopinavir/Ritonavir- and Nevirapine-Based Antiretroviral
Therapy in Sub-Saharan Africa: A5208 (OCTANE)
SO JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES
LA English
DT Article
DE HIV-1; women; Africa; nevirapine; lopinavir; ritonavir; cardiovascular
disease risk factors
ID IMMUNODEFICIENCY-VIRUS-INFECTION; ISCHEMIC-HEART-DISEASE;
MYOCARDIAL-INFARCTION; PROTEASE INHIBITORS; NONFASTING TRIGLYCERIDES;
EVENTS; COHORT; LIPIDS; AIDS; MEN
AB Background:Limited comparative, prospective data exist regarding cardiovascular risk factors in HIV-infected women starting antiretroviral therapy in Africa.Methods:In 7 African countries, 741 women with CD4 <200 cells/mm(3) were randomized to tenofovir/emtricitabine (TDF/FTC) plus either nevirapine (NVP, n = 370) or lopinavir/ritonavir (LPV/r, n = 371). Lipids and blood pressure (BP) were evaluated at entry, 48, 96, and 144 weeks. Multivariable linear and logistic regression models were used to evaluate mean risk factor changes and clinically relevant risk factor changes.Results:At entry, both NVP and LPV/r groups were similar regarding age [mean = 33.5 (SD = 7.1) years], CD4 [129 (67) cells/mm(3)], and HIV-1 RNA [5.1 (0.6) log(10) copies/mL]. Nearly, all women had normal lipids and BP except for high-density lipoprotein (HDL)-cholesterol. Over 144 weeks, the LPV/r compared with NVP group had significantly greater mean lipid increases (eg, non-HDL: +29 vs. +13 mg/dL) and smaller HDL increases (+12 vs. +21 mg/dL). In contrast, the NVP compared with LPV/r group had greater mean increases in BP (eg, diastolic BP: +5 vs. -0.5 mm Hg). Significantly, more women assigned LPV/r had week 144 abnormal lipid levels (eg, HDL 29.7% vs. 14.8% and triglycerides 28.6% vs. 8.2%), and significantly, more women assigned NVP had abnormal BP (eg, diastolic BP 22.7% vs. 6.5%). Most differences remained significant when adjusted for baseline risk factor, age, CD4, and HIV-1 RNA.Conclusions:In HIV-infected women initiating antiretroviral therapy in Africa, LPV/r + TDF/FTC was associated with less favorable changes in lipids, and use of NVP + TDF/FTC was associated with less favorable changes in BP.
C1 [Shaffer, Douglas; Sawe, Fredrick] Kenya Govt Med Res Ctr, Walter Reed Project, Kericho, Kenya.
[Shaffer, Douglas; Sawe, Fredrick] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD USA.
[Hughes, Michael D.; Bao, Yajing; Lockman, Shahin] Harvard Univ, Sch Publ Hlth, Boston, MA 02115 USA.
[Sawe, Fredrick] Henry M Jackson Fdn Adv Mil Med, Rockville, MD USA.
[Moses, Agnes] Univ North Carolina Project, Kamuzu Cent Hosp, Lilongwe, Malawi.
[Hogg, Evelyn] Social & Sci Syst Inc, Silver Spring, MD USA.
[Lockman, Shahin] Brigham & Womens Hosp, Boston, MA 02115 USA.
[Lockman, Shahin] Botswana Harvard Sch Publ Hlth AIDS Initiat Partn, Gaborone, Botswana.
[Currier, Judith] Univ Calif Los Angeles, Los Angeles, CA USA.
RP Shaffer, D (reprint author), US Embassy, Ctr Dis Control & Prevent CDC, 2657 Ave Gendarmerie,POB 28, Kigali, Rwanda.
EM DShaffer@cdc.gov
FU National Institute of Allergy and Infectious Diseases [U01AI068636,
AI38838]; Statistical and Data Management Center, National Institute of
Allergy and Infectious Diseases [AI68634]; General Clinical Research
Center Units - National Center for Research; National Institute of
Allergy and Infectious Diseases-US Army Medical Research and Material
Command IAA [IAAY1AI8374]; UNC Project, Kamuzu Central Hospital;
Lilongwe CTU Grant [5 U01 AI069518]; [K24 AI56933]
FX Supported in part by grants (U01AI068636, AI38838, and Statistical and
Data Management Center AI68634) from the National Institute of Allergy
and Infectious Diseases to the AIDS Clinical Trials Group. Supported in
part by the General Clinical Research Center Units funded by the
National Center for Research. D. S. and F. S. as part of the US Military
HIV Research Unit Clinical Trials Unit are supported through the
National Institute of Allergy and Infectious Diseases-US Army Medical
Research and Material Command IAA (#IAAY1AI8374). A. M. is supported
through the UNC Project, Kamuzu Central Hospital; Lilongwe (Site 12001)
CTU Grant #5 U01 AI069518. J.C. is supported in part by K24 AI56933.
NR 41
TC 2
Z9 2
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1525-4135
EI 1077-9450
J9 JAIDS-J ACQ IMM DEF
JI JAIDS
PD JUN 1
PY 2014
VL 66
IS 2
BP 155
EP 163
DI 10.1097/QAI.0000000000000131
PG 9
WC Immunology; Infectious Diseases
SC Immunology; Infectious Diseases
GA AJ4YJ
UT WOS:000337685800017
PM 24562349
ER
PT J
AU Chun, HM
Mesner, O
Thio, CL
Bebu, I
Macalino, G
Agan, BK
Bradley, WP
Malia, J
Peel, SA
Jagodzinski, LL
Weintrob, AC
Ganesan, A
Bavaro, M
Maguire, JD
Landrum, ML
AF Chun, Helen M.
Mesner, Octavio
Thio, Chloe L.
Bebu, Ionut
Macalino, Grace
Agan, Brian K.
Bradley, William P.
Malia, Jennifer
Peel, Sheila A.
Jagodzinski, Linda L.
Weintrob, Amy C.
Ganesan, Anuradha
Bavaro, Mary
Maguire, Jason D.
Landrum, Michael L.
CA Infect Dis Clinical Res Program HI
TI HIV Outcomes in Hepatitis B Virus Coinfected Individuals on HAART
SO JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES
LA English
DT Article
DE hepatitis B virus; chronic hepatitis B; HIV; highly active
antiretroviral therapy
ID HUMAN-IMMUNODEFICIENCY-VIRUS; ACTIVE ANTIRETROVIRAL THERAPY; INFECTED
PATIENTS; RAPID PROGRESSION; NATURAL-HISTORY; HOMOSEXUAL-MEN; COHORT;
AIDS; PREVALENCE; RISK
AB Background:Understanding the impact of hepatitis B virus (HBV) coinfection on HIV outcomes in the highly active antiretroviral therapy (HAART) era continues to be a critical priority given the high prevalence of coinfection and the potential for impaired immunologic, virologic, and clinical recovery.Methods:Participants from the US Military HIV Natural History Study with an HIV diagnosis on HAART and serologically confirmed HBV infection status at HAART initiation (HI) were classified into 4 HBV infection (HB) groups. HIV virologic, immunologic, and clinical outcomes were evaluated by HB status.Results:Of 2536 HIV-positive HAART recipients, with HBV testing results available to determine HB status in the HI window, HB status at HI was classified as HB negative (n = 1505; 66%), resolved HB (n = 518; 23%), isolated hepatitis B core antigen (n = 139; 6%), or chronic HB (n = 131; 6%). HIV virologic suppression and failure at 6 months or 1 year were not significantly different by HB status. A significantly faster rate of increase in CD4 cell count during the period between 4 and 12 years was observed for chronic HB relative to HB negative. Chronic and resolved HB were associated with an increased risk of AIDS/death compared with HB-negative individuals (chronic HBhazard ratio = 1.68, 95% confidence interval: 1.05 to 2.68; resolved HBhazard ratio = 1.61, 95% confidence interval: 1.15 to 2.25).Conclusions:HB status did not have a significant impact on HIV virologic outcomes, however, CD4 cell count reconstitution after HI and the risk of an AIDS event or death after HI may be associated with HB status.
C1 [Chun, Helen M.; Mesner, Octavio; Bebu, Ionut; Macalino, Grace; Agan, Brian K.; Bradley, William P.; Malia, Jennifer; Peel, Sheila A.; Jagodzinski, Linda L.; Weintrob, Amy C.; Ganesan, Anuradha; Bavaro, Mary; Maguire, Jason D.] Uniformed Serv Univ Hlth Sci, Infect Dis Clin Res Program, Bethesda, MD 20814 USA.
[Thio, Chloe L.] Johns Hopkins Univ, Div Infect Dis, Baltimore, MD USA.
[Malia, Jennifer; Peel, Sheila A.; Jagodzinski, Linda L.] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD USA.
[Weintrob, Amy C.; Ganesan, Anuradha] Walter Reed Natl Mil Med Ctr, Div Infect Dis, Bethesda, MD USA.
[Bavaro, Mary] Naval Med Ctr, Infect Dis Clin, San Diego, CA USA.
[Maguire, Jason D.] Naval Med Ctr, Div Infect Dis, Portsmouth, VA USA.
[Landrum, Michael L.] Bellin Hlth Green Bay & Clin Hispana, Green Bay, WI USA.
RP Chun, HM (reprint author), Infect Dis Clin Res Program, 11300 Rockville Pike,Suite 600, North Bethesda, MD 20852 USA.
EM vgi2@cdc.gov
OI Agan, Brian/0000-0002-5114-1669
FU Infectious Diseases Clinical Research Program (IDCRP); DoD through
Uniformed Services University of the Health Sciences; National Institute
of Allergy and Infectious Diseases (NIAID), National Institutes of
Health (NIH) [Y1-AI-5072]
FX Supported by the Infectious Diseases Clinical Research Program (IDCRP,
www.idcrp.org), a DoD program executed through Uniformed Services
University of the Health Sciences. This project has been funded in
whole, or in part, with federal funds from the National Institute of
Allergy and Infectious Diseases (NIAID), National Institutes of Health
(NIH), under Inter-Agency Agreement Y1-AI-5072. The IDCRP reviewed the
study design, collected the data, and provided salary support to
investigators (M.L.L., A.C.W., A.G., and B.K.A.). The analyses,
conclusions, and decision to submit the article are the independent work
and decision of the authors.
NR 36
TC 8
Z9 8
U1 0
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1525-4135
EI 1077-9450
J9 JAIDS-J ACQ IMM DEF
JI JAIDS
PD JUN 1
PY 2014
VL 66
IS 2
BP 197
EP 205
DI 10.1097/QAI.0000000000000142
PG 9
WC Immunology; Infectious Diseases
SC Immunology; Infectious Diseases
GA AJ4YJ
UT WOS:000337685800023
PM 24694929
ER
PT J
AU Minogue, TD
Kalina, WV
Coyne, SR
AF Minogue, Timothy Devin
Kalina, Warren Vincent
Coyne, Susan Rajnik
TI Stabilization of biothreat diagnostic samples through vitrification
matrices
SO JOURNAL OF MICROBIOLOGICAL METHODS
LA English
DT Article
DE CloneStable; RNAStable; Yersina; Venezuelan Equine Encephalitis
ID POLYMERASE CHAIN-REACTION; VIRAL-RNA; STORAGE; VIRUS; PCR; PLATFORMS;
AGENTS
AB Diagnostics for biothreat agents require sample shipment to reference labs for diagnosis of disease; however high/fluctuating temperatures during sample transport negatively affect sample quality and results. Vitrification additives preserve sample integrity for molecular-based assay diagnostics in the absence of refrigeration by imparting whole molecule stability to a plethora of environmental insults. Therefore, we have evaluated commercially available vitrification matrices' (Biomatrica's CloneStable (R) and RNAStable (R)) ability to stabilize samples of Yersinia pestis and Venezuelan Equine Encephalitis Virus. When heated to 95 degrees C in RNAStable (R), Y. pestis had a 13-fold improvement in detection via real-time PCR compared to heated samples in buffer. VEEV, in RNAStable (R) at 55 degrees C, had a similar to 10-fold improved detection versus heated samples in buffer. CloneStable (R) also preserved Y. pestis antigens for 7 days after exposure to cycling temperatures. Overall, RNAStable (R) and CloneStable (R) respectively offered superior stabilization to nucleic acids and proteins in response to temperature fluctuations. (C) 2014 Published by Elsevier B.V.
C1 [Minogue, Timothy Devin; Kalina, Warren Vincent; Coyne, Susan Rajnik] US Army, Res Inst Infect Dis, Diagnost Syst Div, Ft Detrick, MD 21702 USA.
RP Minogue, TD (reprint author), US Army, Res Inst Infect Dis, Diagnost Syst Div, 1425 Porter St, Ft Detrick, MD 21702 USA.
EM timothy.d.minogue.civ@mail.mil
FU Joint Science & Technology Office for Chemical & Biological Defense
[CB3901]
FX This work was supported by the Joint Science & Technology Office for
Chemical & Biological Defense under Grant No. CB3901. Opinions,
interpretations, conclusions, and recommendation are those of the author
and are not necessarily endorsed by the U.S. Army.
NR 24
TC 0
Z9 0
U1 0
U2 8
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0167-7012
EI 1872-8359
J9 J MICROBIOL METH
JI J. Microbiol. Methods
PD JUN
PY 2014
VL 101
BP 81
EP 85
DI 10.1016/j.mimet.2014.04.002
PG 5
WC Biochemical Research Methods; Microbiology
SC Biochemistry & Molecular Biology; Microbiology
GA AJ4PW
UT WOS:000337659300013
PM 24742968
ER
PT J
AU Penn-Barwell, JG
Murray, CK
Wenke, JC
AF Penn-Barwell, Jowan G.
Murray, Clinton K.
Wenke, Joseph C.
TI Local Antibiotic Delivery by a Bioabsorbable Gel Is Superior to PMMA
Bead Depot in Reducing Infection in an Open Fracture Model
SO JOURNAL OF ORTHOPAEDIC TRAUMA
LA English
DT Article
DE open fracture; wounds and injuries; infection; antibiotics; local
antibiotics; antibiotic beads; bacteria
ID GENTAMICIN-COLLAGEN SPONGE; PRESSURE WOUND THERAPY; CHRONIC
OSTEOMYELITIS; COMPOUND FRACTURES; TIBIAL FRACTURES; SEGMENTAL DEFECT;
DEEP INFECTION; BONE-FORMATION; CEMENT BEADS; LONG-TERM
AB Objectives: Local delivery allows a high concentration of antibiotics to be achieved in the wound while avoiding the side effects and cost of systemic administration. Beads molded from polymethylmethacrylate cement are commonly used for local antibiotic delivery but are not ideal. The purpose of this study was to determine whether a bioabsorbable gel delivering vancomycin and gentamicin is more effective in reducing infection than beads delivering vancomycin and tobramycin.
Methods: This study used a segmental defect rat model contaminated with Staphylococcus aureus and treated with clinically relevant local antibiotic doses, delivered by gel or beads. In the gel group, 1 mL of gel containing gentamicin and vancomycin was spread throughout the wound. In the bead group, four 3-mm beads containing tobramycin and vancomycin were placed in the wound, 2 in the defect and 2 in the adjacent tissue envelope, there was also a control group that received no antibiotic treatment. After 14 days, bone and hardware was harvested for separate microbiological analysis.
Results: There was a significantly lower infection rate in groups treated with antibiotics delivered by gel compared with those treated with either antibiotic beads or no antibiotics at all (P < 0.001). Quantitative cultures also demonstrate significantly less bacteria in the wounds treated with the gel than in the control or bead groups (P <= 0.004).
Conclusions: These results suggest that antibiotic delivery by a gel is superior to beads. The authors propose that antibiotic depot by polymethylmethacrylate antibiotic beads is less effective because this method has to rely on diffusion of the antibiotic from the high concentration close to the beads to all regions of the wound.
C1 [Penn-Barwell, Jowan G.; Wenke, Joseph C.] US Army Inst Surg Res, San Antonio, TX USA.
[Penn-Barwell, Jowan G.] Royal Ctr Def Med, Acad Dept Mil Surg & Trauma, Birmingham B15 2SQ, W Midlands, England.
[Murray, Clinton K.] Brooke Army Med Ctr, Infect Dis Serv, San Antonio, TX USA.
RP Penn-Barwell, JG (reprint author), Royal Ctr Def Med, Acad Dept Mil Surg & Trauma, Birmingham B15 2SQ, W Midlands, England.
EM jowan@doctors.net.uk
NR 34
TC 11
Z9 12
U1 0
U2 8
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0890-5339
EI 1531-2291
J9 J ORTHOP TRAUMA
JI J. Orthop. Trauma
PD JUN
PY 2014
VL 28
IS 6
BP 370
EP 375
PG 6
WC Orthopedics; Sport Sciences
SC Orthopedics; Sport Sciences
GA AJ5AM
UT WOS:000337692600017
PM 23948961
ER
PT J
AU Knox, J
Schneider, J
Wimberly, RL
Riccio, AI
AF Knox, Jeffrey
Schneider, John
Wimberly, Robert L.
Riccio, Anthony I.
TI Characteristics of Spinal Injuries Secondary to Nonaccidental Trauma
SO JOURNAL OF PEDIATRIC ORTHOPAEDICS
LA English
DT Article
DE nonaccidental trauma; pediatric spine fracture; cervical spine
ID CHILD-ABUSE; CERVICAL-SPINE; PEDIATRIC SPINE; FRACTURES; CORD; PATTERNS
AB Background: Nonaccidental trauma (NAT) is considered an uncommon cause of spine trauma in the pediatric population. Little has been published on such injuries and no large series is available in the literature. The purpose of this study is to describe the incidence and characteristics of spine trauma secondary to NAT.
Methods: An IRB-approved retrospective review of all patients presenting to a single level 1 pediatric trauma center with a spinal injury between 2003 and 2011 was performed. Patients were identified using our institution's trauma registry. Medical records were reviewed to identify all spine injuries that occurred as a result of NAT. These cases were reviewed for details regarding injury mechanism, type and location of injury, associated injuries, and the treatment. Our institution's NAT database was also queried to identify the total number of patients formally determined to have sustained any injury as a result of NAT during the same period.
Results: NAT was the cause of 11/342 (3.2%) spine injuries diagnosed during the study period. A total of 726 cases of NAT were identified, with spine injury present in 1.5%. All patients with spine trauma secondary to NAT were under the age of 2 years with an average age of 7 months. Among patients below 2 years with spinal trauma, NAT was tied as the most common mechanism, resulting in 38% of injuries. Eight of the 11 patients' spine injuries were cervical and 7 of these injuries were in the atlanto-occipital and atlantoaxial regions. Multilevel spine trauma was present in 64% of patients. Associated head and thoracic trauma was present in 73% and 36% of patients, respectively. Neurological injury was found in 54% of patients. The majority of injuries were treated nonoperatively and 1 patient required surgical management.
Conclusions: NAT represents a very common yet often overlooked cause of spinal trauma in children under the age of 2 years. Because of its frequency in this age group, clinicians should consider including an assessment of the spine in all young NAT patients. Patients with spinal trauma sustained as a result of NAT must undergo a thorough evaluation for associated injuries remote to the spine, neurological deficit, and multilevel spine injury.
Summary: NAT is a common mechanism of spinal injury in patients below 2 years of age.
C1 [Knox, Jeffrey] Tripler Army Med Ctr, Orthoped Surg Serv, Honolulu, HI 96859 USA.
[Schneider, John] Univ Texas SW Med Ctr Dallas, Dept Pediat, Dallas, TX 75390 USA.
[Schneider, John; Wimberly, Robert L.; Riccio, Anthony I.] Childrens Med Ctr, Dallas, TX 75235 USA.
[Wimberly, Robert L.; Riccio, Anthony I.] Texas Scottish Rite Hosp Children, Dept Orthoped, Dallas, TX 75235 USA.
RP Riccio, AI (reprint author), Texas Scottish Rite Hosp Children, Dept Orthoped, Dallas, TX 75235 USA.
EM anthony.riccio@childrens.com
NR 24
TC 7
Z9 7
U1 0
U2 7
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0271-6798
EI 1539-2570
J9 J PEDIATR ORTHOPED
JI J. Pediatr. Orthop.
PD JUN
PY 2014
VL 34
IS 4
BP 376
EP 381
PG 6
WC Orthopedics; Pediatrics
SC Orthopedics; Pediatrics
GA AJ5RQ
UT WOS:000337745100002
PM 24172665
ER
PT J
AU Danabalan, R
Monaghan, MT
Ponsonby, DJ
Linton, YM
AF Danabalan, R.
Monaghan, M. T.
Ponsonby, D. J.
Linton, Y. -M.
TI Occurrence and host preferences of Anopheles maculipennis group
mosquitoes in England and Wales
SO MEDICAL AND VETERINARY ENTOMOLOGY
LA English
DT Article
DE Anopheles atroparvus; Anopheles daciae; Anopheles messeae; bloodmeal;
host preference; ITS-2; PCR-RFLP assay; U; K
ID POLYMERASE-CHAIN-REACTION; COMPLEX DIPTERA; SPECIES DIPTERA; RIBOSOMAL
DNA; CULICIDAE; MALARIA; IDENTIFICATION; BEKLEMISHEVI; RECOGNITION;
BLOODMEALS
AB Mosquitoes of the Anopheles maculipennis Meigen (Diptera: Culicidae) group are of public health concern: five of the 11 morphologically indistinct species have been historically considered as vectors of malaria in Europe. Three members of the An.maculipennis group have been reported in the U.K.: Anopheles atroparvus van Thiel; Anopheles messeae Falleroni, and Anopheles daciae Linton, Nicolescu & Harbach. To study the distribution of the three U.K. species, particularly that of An.daciae, we developed a polymerase chain reaction-Restriction fragment length polymorphism (PCR-RFLP) assay using the nuclear ribosomal internal transcribed spacer 2 (ITS-2) gene. Anopheles daciae was found to be widespread, occurring in four of the five counties surveyed in southern England and on the Welsh island of Anglesey, often in sympatry with the closely related species An.messeae. The host preferences of 237 blood-fed females were determined using either direct sequencing or PCR-based fragment analysis of the mitochondrial cytochrome oxidase b gene with DNA from females' abdomens. All three species were found to be opportunistic, having fed on at least three different hosts. Seventeen individuals contained multiple bloodmeals, including two An.daciae that had fed on humans and birds. Our results show that An.daciae is widespread in England and Wales, occurs in sympatry with other members of the An.maculipennis group, and feeds on humans, which suggests it is a potential vector of disease in the U.K.
C1 [Danabalan, R.] Museum Nat Kunde, Dept Res, D-10115 Berlin, Germany.
[Danabalan, R.; Ponsonby, D. J.] Canterbury Christ Church Univ, Dept Geog & Life Sci, Canterbury, Kent, England.
[Danabalan, R.; Linton, Y. -M.] Nat Hist Museum, Dept Entomol, London SW7 5BD, England.
[Monaghan, M. T.] Leibniz Inst Freshwater Ecol & Inland Fisheries, Berlin, Germany.
[Linton, Y. -M.] Walter Reed Army Inst Res, Entomol Branch, Silver Spring, MD USA.
RP Danabalan, R (reprint author), Museum Nat Kunde, Dept Res, Invalidenstr 43, D-10115 Berlin, Germany.
EM Renita.Danabalan@mfn-berlin.de
RI Monaghan, Michael/A-2589-2009
OI Monaghan, Michael/0000-0001-6200-2376
FU Canterbury Christ Church University; Natural History Museum in London
FX This study formed part of the PhD thesis of RD and was funded through a
PhD studentship from Canterbury Christ Church University awarded to RD,
DJP and YML. Field collections were funded by the Natural History Museum
in London (to YML). Field collections were carried out with some
assistance from Magdalena Zarowiecki. The authors are extremely grateful
to all landowners, the Royal Society for the Protection of Birds
(Exminster Marshes) and the staff of Pettitts Animal Adventure Park for
allowing mosquito collections to take place on their properties. This
manuscript was prepared whilst YML held a National Research Council
Research Associateship Award at the Walter Reed Army Institute of
Research. This material reflects the views of the authors and should not
be construed as representing those of the U.S. Department of the Army or
the U.S. Department of Defense.
NR 52
TC 7
Z9 8
U1 3
U2 16
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0269-283X
EI 1365-2915
J9 MED VET ENTOMOL
JI Med. Vet. Entomol.
PD JUN
PY 2014
VL 28
IS 2
BP 169
EP 178
DI 10.1111/mve.12023
PG 10
WC Entomology; Veterinary Sciences
SC Entomology; Veterinary Sciences
GA AJ3ND
UT WOS:000337572500006
PM 23848304
ER
PT J
AU Kahl, C
Gfoeller, M
Katz, MN
Kimmitt, MT
AF Kahl, Colin
Gfoeller, Michael
Katz, Mark N.
Kimmitt, Mark T.
TI Symposium: US Commitments to the Gulf Arab States: Are They Adequate?
SO MIDDLE EAST POLICY
LA English
DT Editorial Material
C1 [Kahl, Colin] Georgetown Univ, Washington, DC 20057 USA.
[Kahl, Colin] Ctr New Amer Security, Middle East Secur Program, Washington, DC USA.
[Gfoeller, Michael] Chertoff Grp, Washington, DC USA.
[Gfoeller, Michael] ExxonMobil, Int Govt Relat, Middle East & North African Affairs, Irving, TX USA.
[Gfoeller, Michael] US Embassy, Riyadh, Saudi Arabia.
[Katz, Mark N.] George Mason Univ, Fairfax, VA 22030 USA.
[Katz, Mark N.] US Dept State, Washington, DC USA.
[Kimmitt, Mark T.] US Army, Washington, DC USA.
RP Kahl, C (reprint author), Georgetown Univ, Washington, DC 20057 USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1061-1924
EI 1475-4967
J9 MIDDLE EAST POLICY
JI Middle East Policy
PD SUM
PY 2014
VL 21
IS 2
BP 1
EP 33
DI 10.1111/mepo.12067
PG 33
WC Area Studies; International Relations
SC Area Studies; International Relations
GA AJ3DE
UT WOS:000337545000001
ER
PT J
AU Cap, LCAP
AF Cap, Lieutenant Colonel Andrew P.
TI The school of hard knocks: what we've learned and relearned about
transfusion in a decade of global conflict
SO TRANSFUSION MEDICINE
LA English
DT Editorial Material
ID OPERATION ENDURING FREEDOM; COMBAT CASUALTY CARE; FRESH WHOLE-BLOOD;
DAMAGE-CONTROL; AEROMEDICAL EVACUATION; IMPROVED SURVIVAL; INCREASED
PLASMA; TRAUMA SYSTEMS; MILITARY; WAR
C1 [Cap, Lieutenant Colonel Andrew P.] US Army Inst Surg Res, Coagulat & Blood Res Program, San Antonio, TX 78234 USA.
RP Cap, LCAP (reprint author), US Army Inst Surg Res, JBSA FT Sam Houston, San Antonio, TX 78234 USA.
EM andrew.p.cap.mil@mail.mil
NR 30
TC 0
Z9 0
U1 0
U2 1
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0958-7578
EI 1365-3148
J9 TRANSFUSION MED
JI Transfus. Med.
PD JUN
PY 2014
VL 24
IS 3
BP 135
EP 137
DI 10.1111/tme.12127
PG 3
WC Hematology
SC Hematology
GA AJ3OK
UT WOS:000337576100002
ER
PT J
AU Carra, BJ
Bui-Mansfield, LT
O'Brien, SD
Chen, DC
AF Carra, Bradley J.
Bui-Mansfield, Liem T.
O'Brien, Seth D.
Chen, Dillon C.
TI Sonography of Musculoskeletal Soft-Tissue Masses: Techniques, Pearls,
and Pitfalls
SO AMERICAN JOURNAL OF ROENTGENOLOGY
LA English
DT Article
DE extremities; musculoskeletal system; soft-tissue mass; sonography;
ultrasound
ID MOREL-LAVALLEE LESION; SUPERFICIAL MELANOMA METASTASES; COLOR DOPPLER
SONOGRAPHY; HIGH-RESOLUTION; PATHOLOGICAL CORRELATION; ADULT PATIENTS;
TUMORS; WRIST; US; ULTRASOUND
AB OBJECTIVE. The purpose of this article is to review the appropriate use of ultrasound in the workup of soft-tissue masses of the extremities. The normal sonographic appearance of superficial soft tissues, the importance of proper technique in image acquisition, and the characteristic sonographic appearance of certain masses and potential pitfalls are discussed.
CONCLUSION. Ultrasound is increasingly being used for the initial evaluation of softtissue masses of the extremities. Certain clinical and imaging findings allow diagnosis of selected soft-tissue masses; however, most imaging findings are nonspecific, and further evaluation is necessary. The many potential pitfalls can lead to adverse patient outcomes.
C1 [Carra, Bradley J.] Wilford Hall Ambulatory Surg Ctr, Dept Radiol, Lackland AFB, TX USA.
[Carra, Bradley J.; Bui-Mansfield, Liem T.; O'Brien, Seth D.; Chen, Dillon C.] Brooke Army Med Ctr, JBSA, Dept Radiol, Ft Sam Houston, TX 78234 USA.
[Bui-Mansfield, Liem T.; O'Brien, Seth D.; Chen, Dillon C.] Uniformed Serv Univ Hlth Sci, Dept Radiol & Radiol Sci, Bethesda, MD 20814 USA.
RP Bui-Mansfield, LT (reprint author), Brooke Army Med Ctr, JBSA, Dept Radiol, 3551 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA.
EM liem.t.mansfield.ctr@mail.mil
NR 44
TC 7
Z9 7
U1 0
U2 6
PU AMER ROENTGEN RAY SOC
PI RESTON
PA 1891 PRESTON WHITE DR, SUBSCRIPTION FULFILLMENT, RESTON, VA 22091 USA
SN 0361-803X
EI 1546-3141
J9 AM J ROENTGENOL
JI Am. J. Roentgenol.
PD JUN
PY 2014
VL 202
IS 6
BP 1281
EP 1290
DI 10.2214/AJR.13.11564
PG 10
WC Radiology, Nuclear Medicine & Medical Imaging
SC Radiology, Nuclear Medicine & Medical Imaging
GA AI6DB
UT WOS:000336959000036
PM 24848826
ER
PT J
AU Sviatenko, LK
Gorb, L
Hill, FC
Leszczynska, D
Leszczynski, J
AF Sviatenko, L. K.
Gorb, L.
Hill, F. C.
Leszczynska, D.
Leszczynski, J.
TI Theoretical Study of One-Electron Reduction And Oxidation Potentials of
N-Heterocyclic Compounds
SO CHEMISTRY OF HETEROCYCLIC COMPOUNDS
LA English
DT Article
DE N-heterocyclic compounds; DFT calculations; electrochemistry; redox
potential; solvation
ID POLARIZABLE CONTINUUM MODEL; DENSITY-FUNCTIONAL THEORY; NONCOVALENT
INTERACTIONS; THERMOCHEMICAL KINETICS; HETEROAROMATIC BASES;
HYDROCARBONS; IONIZATION; SOLVATION; PRODUCTS; SOLUTES
AB Computational protocols that successfully predict standard reduction potentials of N-heterocyclic compounds in dimethyl formamide and their standard oxidation potentials in acetonitrile were developed. Different solvation models were verified in conjunction with the MPWB1K/6-31 + G(d) level of density functional theory. For reduction potentials calculations, the PCM(UA0) and SMD(Bondi) models were used to compute solvation energies of neutral forms and anion-radical forms, respectively. For oxidation potential calculations, the best results were obtained by a combination of SMD(UAHF) and PCM(Bondi) models to compute solvation energies of neutral forms and cation-radical forms, respectively. The mean absolute deviations (MAD) and root mean square errors (RMSE) of the current theoretical models for reduction potentials were found to be 0.09 V and 0.10, respectively, and for oxidation potentials MAD = 0.12 V and RMSE = 0.16.
C1 [Sviatenko, L. K.; Leszczynski, J.] Jackson State Univ, Dept Chem & Biochem, Interdisciplinary Nanotox Ctr, Jackson, MS 39217 USA.
[Sviatenko, L. K.] Kirovohrad Volodymyr Vynnychenko State Pedag Univ, UA-25006 Kirovohrad, Ukraine.
[Gorb, L.] Badger Tech Serv Inc, Huntsville, AL 35805 USA.
[Hill, F. C.] US Army ERDC, Vicksburg, MS 39180 USA.
[Leszczynska, D.] Jackson State Univ, Dept Civil & Environm Engn, Interdisciplinary Nanotox Ctr, Jackson, MS 39217 USA.
RP Leszczynski, J (reprint author), Jackson State Univ, Dept Chem & Biochem, Interdisciplinary Nanotox Ctr, 1400 John R Lynch St, Jackson, MS 39217 USA.
EM lsv@icnanotox.org; lgorb@icnanotox.org; frances.c.hill@usace.army.mil;
jerzy@icnanotox.org
FU ERDC [W912HZ-13-P-0037]; National Science Foundation [OCI-1053575];
XSEDE [DMR110088]
FX We thank ERDC for financial support (grant number W912HZ-13-P-0037). The
computation time was provided by the Extreme Science and Engineering
Discovery Environment (XSEDE) by National Science Foundation Grant
Number OCI-1053575 and XSEDE award allocation Number DMR110088 and by
the Mississippi Center for Supercomputer Research.
NR 28
TC 2
Z9 2
U1 1
U2 12
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0009-3122
EI 1573-8353
J9 CHEM HETEROCYCL COM+
JI Chem. Heterocycl. Compds.
PD JUN
PY 2014
VL 50
IS 3
BP 311
EP 318
DI 10.1007/s10593-014-1484-5
PG 8
WC Chemistry, Organic
SC Chemistry
GA AI8DZ
UT WOS:000337138400002
ER
PT J
AU Ramon, ES
Tyo, JS
Ziolkowski, RW
Skipper, MC
Abdalla, MD
Martin, JM
Altgilbers, LL
AF Ramon, Eric S.
Tyo, J. Scott
Ziolkowski, Richard W.
Skipper, Michael C.
Abdalla, Michael D.
Martin, Joshua M.
Altgilbers, Larry L.
TI A Compact Multi-Frequency, High Power Radiating System Combining
Dual-Band, Electrically Small Magnetic EZ Antennas and Multi-Frequency
Standing Wave Oscillator Sources
SO IEEE TRANSACTIONS ON ANTENNAS AND PROPAGATION
LA English
DT Article
DE Electrically small antennas; high power microwave generation; mesoband
sources; multifrequency antennas
AB High power microwave (HPM) sources are typically bulky and massive in order to be able to radiate the extremely high source powers with a good impedance match and low losses. For this reason, it is sometimes difficult to incorporate an HPM antenna onto a desired platform when the available space is small. In previous work, we have adapted an electrically small EZ antenna to operate with a mesoband, quarter-wave oscillator source. The EZ antenna operates over a ground plane, but is conformal and low profile in that the electrical size is on the order of lambda/12, making it attractive for applications where there is sufficient internal space to place a full source, but only limited space outside the platform for the radiating subsystem. Here we extend the capabilities of the oscillator/EZ antenna combination by introducing a dual band design for the antenna and altering the oscillator to produce multiple resonant frequencies. Designs are shown here that operate in the UHF (500-800 MHz) and L-band (1.5-1.8 GHz), but the operation frequencies are essentially arbitrary. This paper shows modeling results that predict high antenna efficiency with electrical sizes of ka < 1 at f = 500 MHz.
C1 [Ramon, Eric S.; Tyo, J. Scott; Ziolkowski, Richard W.] Univ Arizona, Coll Opt Sci, Tucson, AZ 85721 USA.
[Ramon, Eric S.; Tyo, J. Scott; Ziolkowski, Richard W.] Univ Arizona, ECE Dept, Tucson, AZ 85721 USA.
[Skipper, Michael C.; Abdalla, Michael D.] ASR Corp, Albuquerque, NM 87114 USA.
[Martin, Joshua M.; Altgilbers, Larry L.] US Army Space & Missile Def Command, Huntsville, AL 35805 USA.
Missile Def Command, Huntsville, AL 35805 USA.
RP Ramon, ES (reprint author), Univ Arizona, Coll Opt Sci, Tucson, AZ 85721 USA.
FU Phase 2 SBIR award from the US Army
FX This work was supported by a Phase 2 SBIR award from the US Army, and
was cleared for public release by the Public Affairs Office at the Space
& Missile Defense Command, Huntsville, AL, USA.
NR 17
TC 1
Z9 1
U1 0
U2 13
PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
PI PISCATAWAY
PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA
SN 0018-926X
EI 1558-2221
J9 IEEE T ANTENN PROPAG
JI IEEE Trans. Antennas Propag.
PD JUN
PY 2014
VL 62
IS 6
BP 3281
EP 3289
DI 10.1109/TAP.2014.2313135
PG 9
WC Engineering, Electrical & Electronic; Telecommunications
SC Engineering; Telecommunications
GA AI7ZS
UT WOS:000337122100040
ER
PT J
AU Srisurapanon, S
Sukwit, S
Chuenchitra, T
Rojanasang, P
Wongjitrat, C
AF Srisurapanon, Surangrat
Sukwit, Suchitra
Chuenchitra, Thippawan
Rojanasang, Pornparn
Wongjitrat, Chatchawan
TI THE DIFFERENCE BETWEEN THE NUMBERS OF LYMPHOCYTE EXPRESSING
CO-STIMULATORY MOLECULES FROM HBV AND HIV-INFECTED INDIVIDUALS
SO INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY
LA English
DT Meeting Abstract
C1 [Srisurapanon, Surangrat; Rojanasang, Pornparn] Srinakharinwirot Univ, Fac Med, Dept Pathol, Bangkok, Thailand.
[Sukwit, Suchitra; Chuenchitra, Thippawan] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand.
[Wongjitrat, Chatchawan] Srinakharinwirot Univ, Fac Med, Dept Internal Med, Bangkok, Thailand.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1751-5521
EI 1751-553X
J9 INT J LAB HEMATOL
JI Int. J. Lab. Hematol.
PD JUN
PY 2014
VL 36
SU 1
SI SI
BP 101
EP 102
PG 2
WC Hematology
SC Hematology
GA AI9HS
UT WOS:000337244300235
ER
PT J
AU Thompson, M
Sidow, SJ
Lindsey, K
Chuang, A
McPherson, JC
AF Thompson, Matthew
Sidow, Stephanie J.
Lindsey, Kimberly
Chuang, Augustine
McPherson, James C., III
TI Evaluation of a New Filing System's Ability to Maintain Canal Morphology
SO JOURNAL OF ENDODONTICS
LA English
DT Article
DE Hyflex CM; instrumentation; ProFile; transportation
ID SIMULATED ROOT CANALS; CENTERING ABILITY; INSTRUMENTATION TECHNIQUES;
ROTARY INSTRUMENTS; BENDING PROPERTIES; SHAPING ABILITY; NICKEL;
PROFILE; MEMORY; FILES
AB Introduction: The manufacturer of the Hyflex CM endodontic files claims the files remain centered within the canal, and if unwound during treatment, they will regain their original shape after sterilization. The purpose of this study was to evaluate and compare the canal centering ability of the Hyflex CM and the ProFile ISO filing systems after repeated uses in simulated canals, followed by autoclaving. Methods: Sixty acrylic blocks with a canal curvature of 45 degrees were stained with methylene blue, photographed, and divided into 2 groups, H (Hyflex CM) and P (ProFile ISO). The groups were further subdivided into 3 subgroups: H1, H2, H3; P1, P2, P3 (n = 10). Groups H1 and P1 were instrumented to 40 (.04) with the respective file system. Used files were autoclaved for 26 minutes at 126 degrees C. After sterilization, the files were used to instrument groups H2 and P2. The same sterilization and instrumentation procedure was repeated for groups H3 and P3. Post-instrumentation digital images were taken and super-imposed over the pre-instrumentation images. Changes in the location of the center of the canal at predetermined reference points were recorded and compared within subgroups and between filing systems. Results: Statistical differences in intergroup and intragroup transportation measures were analyzed by using the Kruskal-Wallis analysis of variance of ranks with the Bonferroni post hoc test. There was a difference between Hyflex CM and ProFile ISO groups, although it was not statistically significant. Intragroup differences for both Hyflex CM and ProFile ISO groups were not significant (P < .05). Conclusions: The Hyflex CM and Profile ISO files equally maintained the original canal's morphology after 2 sterilization cycles.
C1 [Thompson, Matthew; Sidow, Stephanie J.; Lindsey, Kimberly] US Army Dent Act, Ft Gordon, GA 30905 USA.
[Chuang, Augustine; McPherson, James C., III] Dept Clin Invest, Augusta, GA USA.
RP Lindsey, K (reprint author), US Army Dent Act, Dept Endodont, Ft Gordon, GA 30905 USA.
EM kimberly.w.lindsey.mil@mail.mil
NR 21
TC 1
Z9 3
U1 0
U2 2
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0099-2399
EI 1878-3554
J9 J ENDODONT
JI J. Endod.
PD JUN
PY 2014
VL 40
IS 6
BP 867
EP 870
DI 10.1016/j.joen.2013.10.016
PG 4
WC Dentistry, Oral Surgery & Medicine
SC Dentistry, Oral Surgery & Medicine
GA AI8SW
UT WOS:000337198300019
PM 24862719
ER
PT J
AU Wilmoth, MC
Shapiro, SE
AF Wilmoth, Margaret C.
Shapiro, Susan E.
TI The Intentional Development of Nurses as Leaders A Proposed Framework
SO JOURNAL OF NURSING ADMINISTRATION
LA English
DT Article
ID HEALTH; CARE
AB In their 2010 report on The Future of Nursing, the Institute of Medicine called for nurses to be prepared to lead in all areas of healthcare. However, the nursing profession lacks consensus on a framework to guide the development of nurses as leaders and has yet to define essential leader competencies. This article reviews the Army's intentional, sequential, and progressive leader development program that is grounded in essential leader competencies. The applicability of this model to nursing is discussed, and examples of how it could be applied are highlighted. This article proposes the use of the military framework as a successful model for the intentional development of nurses as leaders to meet the triple aims of better care for patients, better health for populations, and reduced costs of care through more efficient use of resources.
C1 [Wilmoth, Margaret C.] Georgia State Univ, Byrdine F Lewis Sch Nursing & Hlth Profess, Atlanta, GA 30303 USA.
[Wilmoth, Margaret C.] US Army Reserve, Ft Bragg, NC USA.
[Shapiro, Susan E.] Emory Healthcare, Nursing Res & Evidence Based Practice, Atlanta, GA USA.
[Shapiro, Susan E.] Emory Univ, Nell Hodgson Woodruff Sch Nursing, Atlanta, GA 30322 USA.
RP Wilmoth, MC (reprint author), POB 3995, Atlanta, GA 30302 USA.
EM mwilmoth@gsu.edu
NR 26
TC 2
Z9 2
U1 0
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0002-0443
EI 1539-0721
J9 J NURS ADMIN
JI J. Nurs. Adm.
PD JUN
PY 2014
VL 44
IS 6
BP 333
EP 338
DI 10.1097/NNA.0000000000000078
PG 6
WC Nursing
SC Nursing
GA AI8FJ
UT WOS:000337144200007
PM 24853795
ER
PT J
AU Mehra, R
Raghuvanshi, N
Chandak, A
Albert, DG
Wilson, DK
Manocha, D
AF Mehra, Ravish
Raghuvanshi, Nikunj
Chandak, Anish
Albert, Donald G.
Wilson, D. Keith
Manocha, Dinesh
TI Acoustic pulse propagation in an urban environment using a
three-dimensional numerical simulation
SO JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA
LA English
DT Article
ID SOUND-PROPAGATION; NOISE-PROPAGATION; STREET CANYONS; CITY CANYONS;
AREAS; DIFFRACTION; BUILDINGS; EFFICIENT; BARRIERS; IMPULSE
AB Acoustic pulse propagation in outdoor urban environments is a physically complex phenomenon due to the predominance of reflection, diffraction, and scattering. This is especially true in non-line-of-sight cases, where edge diffraction and high-order scattering are major components of acoustic energy transport. Past work by Albert and Liu [J. Acoust. Soc. Am. 127, 1335-1346 (2010)] has shown that many of these effects can be captured using a two-dimensional finite-difference time-domain method, which was compared to the measured data recorded in an army training village. In this paper, a full three-dimensional analysis of acoustic pulse propagation is presented. This analysis is enabled by the adaptive rectangular decomposition method by Raghuvanshi, Narain and Lin [IEEE Trans. Visual. Comput. Graphics 15, 789-801 (2009)], which models sound propagation in the same scene in three dimensions. The simulation is run at a much higher usable bandwidth (nearly 450Hz) and took only a few minutes on a desktop computer. It is shown that a three-dimensional solution provides better agreement with measured data than two-dimensional modeling, especially in cases where propagation over rooftops is important. In general, the predicted acoustic responses match well with measured results for the source/sensor locations.
C1 [Mehra, Ravish; Chandak, Anish; Manocha, Dinesh] Univ N Carolina, Dept Comp Sci, Chapel Hill, NC 27599 USA.
[Raghuvanshi, Nikunj] Microsoft Res, Redmond, WA 98052 USA.
[Albert, Donald G.; Wilson, D. Keith] US Army Cold Reg Res & Engn Lab, Hanover, NH 03755 USA.
RP Mehra, R (reprint author), Univ N Carolina, Dept Comp Sci, Chapel Hill, NC 27599 USA.
EM ravish.mehra07@gmail.com
RI Wilson, D. Keith/A-4687-2012
OI Wilson, D. Keith/0000-0002-8020-6871
FU Link Foundation Fellowship in Advanced Simulation and Training; ARO
[W911NF-10-1-0506, W911NF-12-1-0430, W911NF-13-C-0037]; National Science
Foundation (NSF) [0917040, 1320644]; U.S. Army Engineer Research and
Development Center's Geospatial Research and Engineering business area
FX This research was supported in part by the Link Foundation Fellowship in
Advanced Simulation and Training, ARO Contracts W911NF-10-1-0506,
W911NF-12-1-0430, W911NF-13-C-0037, and the National Science Foundation
(NSF awards 0917040, 1320644). Additional funding for this research was
provided by the U.S. Army Engineer Research and Development Center's
Geospatial Research and Engineering business area.
NR 43
TC 3
Z9 3
U1 1
U2 6
PU ACOUSTICAL SOC AMER AMER INST PHYSICS
PI MELVILLE
PA STE 1 NO 1, 2 HUNTINGTON QUADRANGLE, MELVILLE, NY 11747-4502 USA
SN 0001-4966
EI 1520-8524
J9 J ACOUST SOC AM
JI J. Acoust. Soc. Am.
PD JUN
PY 2014
VL 135
IS 6
BP 3231
EP 3242
DI 10.1121/1.4874495
PG 12
WC Acoustics; Audiology & Speech-Language Pathology
SC Acoustics; Audiology & Speech-Language Pathology
GA AI7VX
UT WOS:000337110200028
PM 24907788
ER
PT J
AU Reine, KJ
Clarke, D
Dickerson, C
AF Reine, Kevin J.
Clarke, Douglas
Dickerson, Charles
TI Characterization of underwater sounds produced by hydraulic and
mechanical dredging operations
SO JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA
LA English
DT Article
ID SHIP NOISE; FISH; ABUNDANCE; SEA
AB Sound recordings were made of two dredging operations at hydrophone depths of 3 and 9.1m at distances up to 1.2 km from the source in shallow waters (< 15 m) of New York Harbor. Sound sources included rock fracturing by a hydraulic cutterhead dredge and six distinct sources associated with a mechanical backhoe dredging operation during rock excavation. To place sound emitted from these dredges in perspective with other anthropogenic sounds, recordings were also made of several deep-draft commercial vessels. Results are presented as sound pressure levels (SPLs) in one-third octave versus range across the 20 Hz to 20 kHz frequency band. To address concerns for protection of fishery resource occupying the harbor, SPL were examined at frequency bands of 50-1000 Hz and 100-400 Hz, the ranges where the majority of fishes without hearing specializations detect sound and the range of greatest sensitivity, respectively. Source levels (dB re 1 mu Pa-1m rms) were back calculated using fitted regression (15LogR). The strongest sound sources (180-188.9 dB) were emitted by commercial shipping. Rock fracturing produced a source level of 175 dB, whereas six distinct sources associated with rock excavation had source levels ranging from 164.2 to 179.4 dB re 1 mu Pa-1m (rms).
C1 [Reine, Kevin J.; Clarke, Douglas] US Army Engineer Res & Dev Ctr, Environm Lab, Wetlands & Coastal Ecol Branch, Vicksburg, MS 39180 USA.
[Dickerson, Charles] Bowhead Sci & Technol Serv, Vicksburg, MS 39180 USA.
RP Reine, KJ (reprint author), US Army Engineer Res & Dev Ctr, Environm Lab, Wetlands & Coastal Ecol Branch, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA.
EM Kevin.J.Reine@usace.army.mil
FU USACE New York District; U.S. Army Engineer Research and Development
Center, Vicksburg, MI - Dredging Operations and Environmental Research
(DOER) Program
FX This study is a joint effort sponsored by the USACE New York District
and the U.S. Army Engineer Research and Development Center, Vicksburg,
MI, supported by the Dredging Operations and Environmental Research
(DOER) Program. The authors wish to express thanks to Kate Alcoba and
Ann Marie Dilorenzo of the Estuaries Section, Planning Division, New
York District; Timothy Lafontaine, Chief of Caven Point Operations, New
York District; and Captain Mike Marcello and First Mate Ray Ryan, crew
of the M/V Hudson, for providing logistical and technical support for
field data collection efforts.
NR 44
TC 4
Z9 4
U1 0
U2 24
PU ACOUSTICAL SOC AMER AMER INST PHYSICS
PI MELVILLE
PA STE 1 NO 1, 2 HUNTINGTON QUADRANGLE, MELVILLE, NY 11747-4502 USA
SN 0001-4966
EI 1520-8524
J9 J ACOUST SOC AM
JI J. Acoust. Soc. Am.
PD JUN
PY 2014
VL 135
IS 6
BP 3280
EP 3294
DI 10.1121/1.4875712
PG 15
WC Acoustics; Audiology & Speech-Language Pathology
SC Acoustics; Audiology & Speech-Language Pathology
GA AI7VX
UT WOS:000337110200032
PM 24907792
ER
PT J
AU Aboudara, M
Mahoney, PF
Hicks, B
Cuadrado, D
AF Aboudara, Matthew
Mahoney, P. F.
Hicks, B.
Cuadrado, D.
TI Primary blast lung injury at a NATO Role 3 hospital
SO JOURNAL OF THE ROYAL ARMY MEDICAL CORPS
LA English
DT Article
DE Respiratory Medicine (see Thoracic Medicine)
ID MANAGEMENT; EPIDEMIOLOGY
AB Background Primary blast lung injury (PBLI) is defined as lung contusion from barotrauma following an explosive mechanism of injury (MOI). Military data have focused on PBLI characteristics following evacuation from the combat theatre; less is known about its immediate management and epidemiology in the deployed setting. We conducted a quality improvement project to describe the prevalence, clinical characteristics, management strategies and evacuation techniques for PBLI patients prior to evacuation.
Methods Patients admitted to a Role 3 hospital in southwest, Afghanistan, from January 2008 to March 2013 with a blast MOI were identified through the Department of Defense Trauma Registry; International Classification of Diseases 9 codes and patient record review were used to identify the PBLI cohort from radiology reports. Descriptive statistics and Fishers exact test were used to report findings.
Results Prevalence of PBLI among blast injured patients with radiology reports was 11.2% (73/648). The population exhibited high Injury Severity Scores median 25 (IQR 14-34) and most received a massive blood transfusion (mean 33.438.3 total blood products/24h). The mean positive end expiratory pressure (PEEP) requirement was 6.2 +/- 3.7 (range 5-15)cm H2O and PaO2 to FiO(2) ratio was 297 +/- 175.2 (66-796)mmHg. However, 16.6% of patients had a PaO2 to FiO(2) ratio <200, 13.3% required PEEP 10cm H2O and one patient required specialised evacuation for respiratory failure. A dismounted MOI (72.8%) and evacuation from point of injury by the Medical Emergency Response Team (62.3%) appeared to be associated with worse lung injury. Only eight of the 73 PBLI patients died and of the five with retrievable records, none died from respiratory failure.
Conclusions PBLI has a low prevalence and conventional lung protective ventilator management is generally appropriate immediately after injury; application of advanced modes of ventilation and specialised evacuation assistance may be required. PBLI may be a marker of underlying injury severity since all deaths were not due to respiratory failure. Further work is needed to determine exact MOI in mounted and dismounted casualties.
C1 [Aboudara, Matthew] Tripler Army Med Ctr, Dept Med, Honolulu, HI 96859 USA.
[Mahoney, P. F.] Royal Ctr Def Med, Dept Mil Anaesthesia & Crit Care, Birmingham, W Midlands, England.
[Hicks, B.] William Beaumont Army Med Ctr, Dept Radiol, El Paso, TX 79920 USA.
[Cuadrado, D.] Vanderbilt Univ, Med Ctr, Vanderbilt Heart Inst, Nashville, TN USA.
RP Aboudara, M (reprint author), Tripler Army Med Ctr, Dept Med, Honolulu, HI 96859 USA.
EM maboudara23@gmail.com
NR 12
TC 5
Z9 6
U1 0
U2 5
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 0035-8665
EI 2052-0468
J9 J ROY ARMY MED CORPS
JI J. R. Army Med. Corps
PD JUN
PY 2014
VL 160
IS 2
BP 161
EP 166
DI 10.1136/jramc-2013-000216
PG 6
WC Medicine, General & Internal
SC General & Internal Medicine
GA AI9YA
UT WOS:000337302200017
PM 24464466
ER
PT J
AU Brown, KV
Penn-Barwell, JG
Rand, BC
Wenke, JC
AF Brown, Kate V.
Penn-Barwell, J. G.
Rand, B. C.
Wenke, J. C.
TI Translational research to improve the treatment of severe extremity
injuries
SO JOURNAL OF THE ROYAL ARMY MEDICAL CORPS
LA English
DT Article
DE Trauma Management
ID BONE MORPHOGENETIC PROTEIN-2; OPEN TIBIAL FRACTURES; SEGMENTAL DEFECT;
INFECTIOUS COMPLICATIONS; POLYURETHANE SCAFFOLDS; REDUCE INFECTION; RAT
FEMUR; MODEL; DELIVERY; WOUNDS
AB Objectives Severe extremity injuries are the most significant injury sustained in combat wounds. Despite optimal clinical management, non-union and infection remain common complications. In a concerted effort to dovetail research efforts, there has been a collaboration between the UK and USA, with British military surgeons conducting translational studies under the auspices of the US Institute of Surgical Research. This paper describes 3years of work.
Methods A variety of studies were conducted using, and developing, a previously validated rat femur critical-sized defect model. Timing of surgical debridement and irrigation, different types of irrigants and different means of delivery of antibiotic and growth factors for infection control and to promote bone healing were investigated.
Results Early debridement and irrigation were independently shown to reduce infection. Normal saline was the most optimal irrigant, superior to disinfectant solutions. A biodegradable gel demonstrated superior antibiotic delivery capabilities than standard polymethylmethacrylate beads. A polyurethane scaffold was shown to have the ability to deliver both antibiotics and growth factors.
Discussion The importance of early transit times to Role 3 capabilities for definitive surgical care has been underlined. Novel and superior methods of antibiotic and growth factor delivery, compared with current clinical standards of care, have been shown. There is the potential for translation to clinical studies to promote infection control and bone healing in these devastating injuries.
C1 [Brown, Kate V.; Penn-Barwell, J. G.; Rand, B. C.; Wenke, J. C.] US Army Inst Surg Res, San Antonio, TX USA.
[Brown, Kate V.; Penn-Barwell, J. G.; Rand, B. C.] Royal Ctr Def Med, Acad Dept Mil Surg & Trauma, Birmingham, W Midlands, England.
RP Brown, KV (reprint author), Royal Army Med Corps, Birmingham B15 2TH, W Midlands, England.
EM katevbrown@aol.com
OI rand, ben/0000-0002-9938-2082
NR 31
TC 1
Z9 1
U1 0
U2 3
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 0035-8665
EI 2052-0468
J9 J ROY ARMY MED CORPS
JI J. R. Army Med. Corps
PD JUN
PY 2014
VL 160
IS 2
BP 167
EP 170
DI 10.1136/jramc-2013-000235
PG 4
WC Medicine, General & Internal
SC General & Internal Medicine
GA AI9YA
UT WOS:000337302200018
PM 24464465
ER
PT J
AU Gillespie, DL
Cherry, KJ
Evans, T
Corpus, R
Rasmussen, T
AF Gillespie, David L.
Cherry, Kenneth J.
Evans, Thomas
Corpus, Raul
Rasmussen, Todd
TI Civilian/Military Collaboration in the Management of Military Vascular
Trauma: A 10-year Report of the SVS Volunteer Program
SO JOURNAL OF VASCULAR SURGERY
LA English
DT Meeting Abstract
CT Vascular Annual Meeting of the Society-for-Vascular-Surgery
CY JUN 05-07, 2014
CL Boston, MA
SP Soc Vasc Surg
C1 [Gillespie, David L.] Southcoast Hlth Syst, Cardiovasc Care Ctr, Fall River, MA USA.
[Cherry, Kenneth J.] Univ Virginia, Charlottesville, VA USA.
[Corpus, Raul] US Army Inst Surg Res, San Antonio, TX USA.
[Evans, Thomas] Wilford Hall USAF Med Ctr, San Antonio, TX 78236 USA.
[Rasmussen, Todd] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA.
NR 0
TC 0
Z9 0
U1 1
U2 2
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0741-5214
J9 J VASC SURG
JI J. Vasc. Surg.
PD JUN
PY 2014
VL 59
IS 6
SU S
BP 35S
EP 36S
PG 2
WC Surgery; Peripheral Vascular Disease
SC Surgery; Cardiovascular System & Cardiology
GA AI9ND
UT WOS:000337258400071
ER
PT J
AU Perkins, ZB
Yet, B
Glasgow, S
Marsh, W
Brohi, K
Rasmussen, TE
Tai, NR
AF Perkins, Zane B.
Yet, Barbaros
Glasgow, Simon
Marsh, William
Brohi, Karim
Rasmussen, Todd E.
Tai, Nigel R.
TI Prognostic Factors for Amputation Following Surgical Repair of Lower
Extremity Vascular Trauma: A Systematic Review and Meta-Analysis of
Observational Studies
SO JOURNAL OF VASCULAR SURGERY
LA English
DT Meeting Abstract
CT Vascular Annual Meeting of the Society-for-Vascular-Surgery
CY JUN 05-07, 2014
CL Boston, MA
SP Soc Vasc Surg
C1 [Perkins, Zane B.; Glasgow, Simon; Brohi, Karim] Univ London, Ctr Trauma Sci, London, England.
[Tai, Nigel R.] Royal Ctr Def Med, Birmingham, W Midlands, England.
[Rasmussen, Todd E.] US Army Inst Surg Res, San Antonio, TX USA.
[Yet, Barbaros; Marsh, William] Univ London, London, England.
RI Marsh, David/A-3213-2016
OI Marsh, David/0000-0003-0212-6363
NR 0
TC 0
Z9 0
U1 0
U2 2
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0741-5214
J9 J VASC SURG
JI J. Vasc. Surg.
PD JUN
PY 2014
VL 59
IS 6
SU S
BP 75S
EP 75S
PG 1
WC Surgery; Peripheral Vascular Disease
SC Surgery; Cardiovascular System & Cardiology
GA AI9ND
UT WOS:000337258400154
ER
PT J
AU Heafner, TA
Lewis, C
Abercrombie, J
Propper, B
Ching, YM
Arthurs, ZM
AF Heafner, Thomas A.
Lewis, Clayton
Abercrombie, Jonathan
Propper, Brandon
Ching, Yiming
Arthurs, Zachary M.
TI Quantitative In Vitro Model for the Study of Bacterial Attachment on
Vascular Conduits
SO JOURNAL OF VASCULAR SURGERY
LA English
DT Meeting Abstract
CT Vascular Annual Meeting of the Society-for-Vascular-Surgery
CY JUN 05-07, 2014
CL Boston, MA
SP Soc Vasc Surg
C1 [Heafner, Thomas A.; Lewis, Clayton; Propper, Brandon; Ching, Yiming; Arthurs, Zachary M.] San Antonio Mil Med Ctr, Ft Sam Houston, TX USA.
[Abercrombie, Jonathan] US Army Inst Surg Res, Ft Sam Houston, TX USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0741-5214
J9 J VASC SURG
JI J. Vasc. Surg.
PD JUN
PY 2014
VL 59
IS 6
SU S
BP 85S
EP 86S
PG 2
WC Surgery; Peripheral Vascular Disease
SC Surgery; Cardiovascular System & Cardiology
GA AI9ND
UT WOS:000337258400178
ER
PT J
AU Yu, LL
Lee, YH
Ling, X
Santos, EJG
Shin, YC
Lin, YX
Dubey, M
Kaxiras, E
Kong, J
Wang, H
Palacios, T
AF Yu, Lili
Lee, Yi-Hsien
Ling, Xi
Santos, Elton J. G.
Shin, Yong Cheol
Lin, Yuxuan
Dubey, Madan
Kaxiras, Efthimios
Kong, Jing
Wang, Han
Palacios, Tomas
TI Graphene/MoS2 Hybrid Technology for Large-Scale Two-Dimensional
Electronics
SO NANO LETTERS
LA English
DT Article
DE Molybdenum disulfide; graphene; heterostructure; field-effect
transistor; integrated circuits; flexible and transparent
ID CHEMICAL-VAPOR-DEPOSITION; THIN-FILM TRANSISTORS; MOS2 TRANSISTORS;
LARGE-AREA; HIGH-PERFORMANCE; HIGH-QUALITY; HETEROSTRUCTURES;
DIELECTRICS
AB Two-dimensional (2D) materials have generated great interest in the past few years as a new toolbox for electronics. This family of materials includes, among others, metallic graphene, semiconducting transition metal dichalcogenides (such as MoS2), and insulating boron nitride. These materials and their heterostructures offer excellent mechanical flexibility, optical transparency, and favorable transport properties for realizing electronic, sensing, and optical systems on arbitrary surfaces. In this paper, we demonstrate a novel technology for constructing large-scale electronic systems based on graphene/molybdenum disulfide (MoS2) heterostructures grown by chemical vapor deposition. We have fabricated high-performance devices and circuits based on this heterostructure, where MoS2 is used as the transistor channel and graphene as contact electrodes and circuit interconnects. We provide a systematic comparison of the graphene/MoS2 heterojunction contact to more traditional MoS2-metal junctions, as well as a theoretical investigation, using density functional theory, of the origin of the Schottky barrier height. The tunability of the graphene work function with electrostatic doping significantly improves the ohmic contact to MoS2. These high-performance large-scale devices and circuits based on this 2D heterostructure pave the way for practical flexible transparent electronics.
C1 [Yu, Lili; Ling, Xi; Lin, Yuxuan; Kong, Jing; Wang, Han; Palacios, Tomas] MIT, Dept Elect Engn & Comp Sci, Cambridge, MA 02139 USA.
[Lee, Yi-Hsien] Natl Tsing Hua Univ, Hsinchu 30013, Taiwan.
[Santos, Elton J. G.; Kaxiras, Efthimios] Harvard Univ, Sch Engn & Appl Sci, Cambridge, MA 02138 USA.
[Shin, Yong Cheol] MIT, Dept Mat Sci & Engn, Cambridge, MA 02139 USA.
[Dubey, Madan] US Army, Res Lab, Adelphi, MD 20783 USA.
[Kaxiras, Efthimios] Harvard Univ, Dept Phys, Cambridge, MA 02138 USA.
RP Yu, LL (reprint author), MIT, Dept Elect Engn & Comp Sci, 77 Massachusetts Ave, Cambridge, MA 02139 USA.
EM liliyu@mit.edu; hw254@mit.edu; tpalacios@mit.edu
FU NSF [TG-DMR120049, TG-PHY120021]
FX The authors would like to thank Allen Hsu and Xu Zhang for their helpful
advice on device fabrication and measurement. The authors acknowledge
financial support from the Office of Naval Research (ONR) PECASE
Program, the ONR GATE MUM program, the Army Research Laboratory, and
Center for Integrated Quantum Materials (CIQM). This research has made
use of the MIT's Microsystem Technology Laboratory cleanrooms. We
acknowledge the use of computational resources provided by the Extreme
Science and Engineering Discovery Environment (XSEDE), supported by NSF
Grants TG-DMR120049 and TG-PHY120021.
NR 54
TC 128
Z9 128
U1 56
U2 475
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 1530-6984
EI 1530-6992
J9 NANO LETT
JI Nano Lett.
PD JUN
PY 2014
VL 14
IS 6
BP 3055
EP 3063
DI 10.1021/nl404795z
PG 9
WC Chemistry, Multidisciplinary; Chemistry, Physical; Nanoscience &
Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied;
Physics, Condensed Matter
SC Chemistry; Science & Technology - Other Topics; Materials Science;
Physics
GA AJ0JP
UT WOS:000337337100014
PM 24810658
ER
PT J
AU Rokni, MR
Widener, CA
Ahrenkiel, SP
Jasthi, BK
Champagne, VR
AF Rokni, M. R.
Widener, C. A.
Ahrenkiel, S. P.
Jasthi, B. K.
Champagne, V. R.
TI Annealing behaviour of 6061 aluminium deposited by high pressure cold
spray
SO SURFACE ENGINEERING
LA English
DT Article
DE Aluminium; Cold spraying; Segregation; Annealing; TEM
ID VACANCY FORMATION ENERGIES; REDUCING GRAIN-BOUNDARY; AL-MG ALLOYS;
SOLUTE SEGREGATION; MECHANICAL-PROPERTIES; DISLOCATION LINE; DIFFUSION;
COATINGS; MICROSTRUCTURE; DIFFRACTION
AB Aluminium 6061 deposited by high pressure cold spray was analysed using a transmission electron microscope (TEM) to characterise its microstructure and response to annealing to 450 degrees C in the plane of the deposition and perpendicular to the deposited layers. The cold sprayed deposition was also analysed with scanning electron microscopy (SEM), energy dispersive X-ray spectroscopy (EDS) analysis and differential scanning calorimeter (DSC). Segregation of the solute atoms (Mg and Si) at the grain boundaries during cold spraying was seen to play a crucial role in stabilising the deformation substructure until specific temperatures, and was found to have a significant effect on the annealing behaviour of the microstructure in the two different directions.
C1 [Rokni, M. R.; Widener, C. A.; Jasthi, B. K.] South Dakota Sch Mines & Technol SDSM&T, Dept Mat & Met Engn, Adv Mat Proc Ctr, Rapid City, SD 57701 USA.
[Ahrenkiel, S. P.] South Dakota Sch Mines & Technol SDSM&T, Dept Nanosci & Nanoengn, Rapid City, SD USA.
[Champagne, V. R.] US Army Res Lab, Weap & Mat Res Directorate, Aberdeen, MD USA.
RP Rokni, MR (reprint author), South Dakota Sch Mines & Technol SDSM&T, Dept Mat & Met Engn, Adv Mat Proc Ctr, Rapid City, SD 57701 USA.
EM mohammadreza.rokni@mines.sdsmt.edu
RI Jasthi, Bharat/D-4312-2009
FU Pueblo Economic Development Corporation under Army Research Lab
[W911NF-11-2-0014]
FX This work was performed under subcontract to the Pueblo Economic
Development Corporation under Army Research Lab contract no.
W911NF-11-2-0014.
NR 44
TC 5
Z9 5
U1 1
U2 16
PU MANEY PUBLISHING
PI LEEDS
PA STE 1C, JOSEPHS WELL, HANOVER WALK, LEEDS LS3 1AB, W YORKS, ENGLAND
SN 0267-0844
EI 1743-2944
J9 SURF ENG
JI Surf. Eng.
PD JUN
PY 2014
VL 30
IS 5
BP 361
EP 368
DI 10.1179/1743294413Y.0000000209
PN 1
PG 8
WC Materials Science, Coatings & Films
SC Materials Science
GA AI8DT
UT WOS:000337137400010
ER
PT J
AU Rini, EA
Weintrob, AC
Tribble, DR
Lloyd, BA
Warkentien, TE
Shaikh, F
Li, P
Aggarwal, D
Carson, ML
Murray, CK
AF Rini, Elizabeth A.
Weintrob, Amy C.
Tribble, David R.
Lloyd, Bradley A.
Warkentien, Tyler E.
Shaikh, Faraz
Li, Ping
Aggarwal, Deepak
Carson, M. Leigh
Murray, Clinton K.
CA Infect Dis Clinical Res Program
TI Short Report: Compliance with Antimalarial Chemoprophylaxis
Recommendations for Wounded United States Military Personnel Admitted to
a Military Treatment Facility
SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
LA English
DT Article
ID AFGHANISTAN; MALARIA; PREVALENCE; MEFLOQUINE; OUTBREAK
AB Malaria chemoprophylaxis is used as a preventive measure in military personnel deployed to malaria-endemic countries. However, limited information is available on compliance with chemoprophylaxis among trauma patients during hospitalization and after discharge. Therefore, we assessed antimalarial primary chemoprophylaxis and presumptive antirelapse therapy (primaquine) compliance among wounded United States military personnel after medical evacuation from Afghanistan (June 2009 August 2011) to Landstuhl Regional Medical Center in Landstuhl, Germany, and then to three U.S. military hospitals. Among admissions at Landstuhl Regional Medical Center, 74% of 2,540 patients were prescribed primary chemoprophylaxis and < 1% were prescribed primaquine. After transfer of 1,331 patients to U.S. hospitals, 93% received primary chemoprophylaxis and 33% received primaquine. Of 751 trauma patients with available post-admission data, 42% received primary chemoprophylaxis for four weeks, 33% received primaquine for 14 days, and 17% received both. These antimalarial chemoprophylaxis prescription rates suggest that improved protocols to continue malaria chemoprophylaxis in accordance with force protection guidelines are needed.
C1 Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA.
[Weintrob, Amy C.; Warkentien, Tyler E.] Walter Reed Natl Mil Med Ctr, Bethesda, MD USA.
[Weintrob, Amy C.; Tribble, David R.; Shaikh, Faraz; Li, Ping; Aggarwal, Deepak; Carson, M. Leigh] Uniformed Serv Univ Hlth Sci, Infect Dis Clin Res Program, Bethesda, MD 20814 USA.
Landstuhl Reg Med Ctr, Landstuhl, Germany.
RP Rini, EA (reprint author), Landstuhl Reg Med Ctr, CMR 402,Box 1838, APO, AE 09180 USA.
EM elizabeth.a.rini.mil@mail.mil; amy.c.weintrob.ctr@health.mil;
david.tribble@usuhs.edu; bradley.lloyd@us.af.mil;
tyler.e.warkentien@health.mil; fshaikh@idcrp.org; pli@idcrp.org;
daggarwal@idcrp.org; lcarson@idcrp.org; clinton.k.murray.mil@mail.mil
FU Infectious Disease Clinical Research Program, a Department of Defense
program through the Uniformed Services University of the Health Sciences
[IDCRP-024]; National Institute of Allergy and Infectious Diseases,
National Institute of Health [Y1-AI-5072]; Department of the Navy
FX The study (IDCRP-024) was supported by the Infectious Disease Clinical
Research Program, a Department of Defense program executed through the
Uniformed Services University of the Health Sciences; the National
Institute of Allergy and Infectious Diseases, National Institute of
Health, under Inter-Agency Agreement Y1-AI-5072; and the Department of
the Navy under the Wounded, Ill, and Injured Program.
NR 18
TC 2
Z9 2
U1 0
U2 2
PU AMER SOC TROP MED & HYGIENE
PI MCLEAN
PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA
SN 0002-9637
EI 1476-1645
J9 AM J TROP MED HYG
JI Am. J. Trop. Med. Hyg.
PD JUN
PY 2014
VL 90
IS 6
BP 1113
EP 1116
DI 10.4269/ajtmh.13-0646
PG 4
WC Public, Environmental & Occupational Health; Tropical Medicine
SC Public, Environmental & Occupational Health; Tropical Medicine
GA AI4FD
UT WOS:000336820200023
PM 24732457
ER
PT J
AU Grogl, M
Sosa, N
Kreishman-Deitrick, M
AF Grogl, Max
Sosa, Nestor
Kreishman-Deitrick, Mara
TI Topical Paromomycin and Gentamicin for New World Cutaneous Leishmaniasis
in Panama Response
SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
LA English
DT Letter
C1 [Grogl, Max] Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD 20910 USA.
[Sosa, Nestor] Inst Conmemorat Gorgas Estudios Salud, Panama City, Panama.
[Kreishman-Deitrick, Mara] USAMMDA, Ft Detrick, MD USA.
RP Grogl, M (reprint author), Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD 20910 USA.
EM max.grogl@gmail.corn
NR 8
TC 0
Z9 0
U1 0
U2 3
PU AMER SOC TROP MED & HYGIENE
PI MCLEAN
PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA
SN 0002-9637
EI 1476-1645
J9 AM J TROP MED HYG
JI Am. J. Trop. Med. Hyg.
PD JUN
PY 2014
VL 90
IS 6
BP 1192
EP 1192
DI 10.4269/ajtmh.14-0040b
PG 1
WC Public, Environmental & Occupational Health; Tropical Medicine
SC Public, Environmental & Occupational Health; Tropical Medicine
GA AI4FD
UT WOS:000336820200039
PM 24898982
ER
PT J
AU Razmi, AM
Barry, DA
Lemmin, U
Bonvin, F
Kohn, T
Bakhtyar, R
AF Razmi, A. M.
Barry, D. A.
Lemmin, U.
Bonvin, F.
Kohn, T.
Bakhtyar, R.
TI Direct effects of dominant winds on residence and travel times in the
wide and open lacustrine embayment: Vidy Bay (Lake Geneva, Switzerland)
SO AQUATIC SCIENCES
LA English
DT Article
DE Delft3D; Hydrodynamics; Particle tracking; Gyre; Dominant winds;
Wastewater effluent
ID PERSONAL CARE PRODUCTS; WATER; MODEL; PHARMACEUTICALS; CIRCULATION;
RESERVOIRS; TRANSPORT; CURRENTS; RISK
AB Numerical simulations were carried out to determine the residence (or flushing) time of water in Vidy Bay (north shore of Lake Geneva) for different meteorological conditions. A hydrodynamic model (Delft3D-FLOW) was applied to simulate the flow field in the embayment during 2010 and January 2011. Using these results, particle tracking was applied to estimate transport of wastewater effluent discharged into the embayment. The model predictions compared well with published field measurements of dissolved species (as given by electrical conductivity profiles) within the wastewater. The pelagic boundary of the embayment was defined by the largest within-bay gyre. Based on this definition, particle tracking was used to quantify the residence time under dominant wind conditions. Similarly, particle tracking was used to determine the travel time (i.e., time to exit the embayment) for each of Vidy Bay's three inflows (stream, stormwater and wastewater effluent). Although the wind field over the lake is variable, current patterns in the embayment can be simulated using the hydrodynamic model forced by a spatially uniform wind field. For a given wind speed, the main factor influencing residence and travel times is the wind angle. The presence of gyres leads to high mean residence times with large variability. As the wind direction becomes more aligned with the shoreline (i.e., with increasing westerly or easterly components), longshore currents dominate. These disrupt gyre formation and markedly reduce the mean and variability of embayment residence time. The numerical model was utilized to assess the potential for plume movement (in plan) from above the wastewater effluent outfall towards one of Lausanne's drinking water intakes. In the most direct pathway, westward longshore currents can move water from the embayment to the water column above the intake location.
C1 [Razmi, A. M.; Barry, D. A.; Lemmin, U.; Bonvin, F.; Kohn, T.; Bakhtyar, R.] Ecole Polytech Fed Lausanne, Fac Environm Nat Architectural & Construit ENAC, Inst Ingn Environm, CH-1015 Lausanne, Switzerland.
[Bakhtyar, R.] US Army Engineer Res & Dev Ctr, Coastal & Hydraul Lab, Vicksburg, MS 39180 USA.
RP Razmi, AM (reprint author), Ecole Polytech Fed Lausanne, Fac Environm Nat Architectural & Construit ENAC, Inst Ingn Environm, Stn 2, CH-1015 Lausanne, Switzerland.
EM amir.razmi@epfl.ch; andrew.barry@epfl.ch; ulrich.lemmin@epfl.ch;
florence.bonvin@epfl.ch; tamar.kohn@epfl.ch; roham.bakhtyar@unc.edu
RI Barry, David/C-6077-2008;
OI Barry, David/0000-0002-8621-0425; Kohn, Tamar/0000-0003-0395-6561
FU Fondation pour l'Etude des Eaux du Leman (FEEL); Swiss National
Foundation [PDFMP2-123034/1]
FX This publication is part of the international, interdisciplinary
research project ELEMO (http://www.elemo.ch) to investigate the
deep-waters of Lake Geneva using two Russian MIR submarines. Funding for
this study was provided by the Fondation pour l'Etude des Eaux du Leman
(FEEL) and the Swiss National Foundation (PDFMP2-123034/1). We thank
Jean-Denis Bourquin for providing administrative support. The authors
thank the three anonymous reviewers and the editor for their useful
comments.
NR 35
TC 5
Z9 6
U1 2
U2 29
PU SPRINGER BASEL AG
PI BASEL
PA PICASSOPLATZ 4, BASEL, 4052, SWITZERLAND
SN 1015-1621
EI 1420-9055
J9 AQUAT SCI
JI Aquat. Sci.
PD JUN
PY 2014
VL 76
SU 1
BP S59
EP S71
DI 10.1007/s00027-013-0321-8
PG 13
WC Environmental Sciences; Limnology; Marine & Freshwater Biology
SC Environmental Sciences & Ecology; Marine & Freshwater Biology
GA AI6HZ
UT WOS:000336974600006
ER
PT J
AU Ellis, MW
Schlett, CD
Millar, EV
Wilkins, KJ
Crawford, KB
Morrison-Rodriguez, SM
Pacha, LA
Gorwitz, RJ
Lanier, JB
Tribble, DR
AF Ellis, Michael W.
Schlett, Carey D.
Millar, Eugene V.
Wilkins, Kenneth J.
Crawford, Katrina B.
Morrison-Rodriguez, Stephanie M.
Pacha, Laura A.
Gorwitz, Rachel J.
Lanier, Jeffrey B.
Tribble, David R.
TI Hygiene Strategies to Prevent Methicillin-Resistant Staphylococcus
aureus Skin and Soft Tissue Infections: A Cluster-Randomized Controlled
Trial Among High-Risk Military Trainees
SO CLINICAL INFECTIOUS DISEASES
LA English
DT Article
DE Staphylococcus aureus; methicillin-resistant Staphylococcus aureus
(MRSA); skin and soft tissue infection; chlorhexidine; military
ID HOUSEHOLD CONTACTS; MARINE RECRUITS; UNITED-STATES; COLONIZATION;
EPIDEMIOLOGY; CELLULITIS; CHILDREN; PREVALENCE; CALIFORNIA; MUPIROCIN
AB Background. Effective measures are needed to prevent methicillin-resistant Staphylococcus aureus (MRSA) skin and soft tissue infections (SSTIs) in high-risk community settings. The study objective was to evaluate the effect of personal hygiene-based strategies on rates of overall SSTI and MRSA SSTI.
Methods. We conducted a prospective, field-based, cluster-randomized trial in US Army Infantry trainees from May 2010 through January 2012. There were 3 study groups with incrementally increased education and hygiene-based interventions: standard (S), enhanced standard (ES), and chlorhexidine (CHG). The primary endpoints were incidence of overall SSTI and MRSA SSTI.
Results. The study included 30 209 trainees constituting 540 platoons (168 S, 192 ES, and 180 CHG). A total of 1203 (4%) participants developed SSTI, 316 (26%) due to MRSA. The overall SSTI rate was 4.15 (95% confidence interval [CI], 3.77-4.58) per 100 person-cycles. SSTI rates by study group were 3.48 (95% CI, 2.87-4.22) for S, 4.18 (95% CI, 3.56-4.90) for ES, and 4.71 (95% CI, 4.03-5.50) for CHG. The MRSA SSTI rate per 100 person-cycles for all groups was 1.10 (95% CI,.91-1.32). MRSA SSTI rates by study group were 1.0 (95% CI,.70-1.42) for S, 1.29 (95% CI,.98-1.71) for ES, and 0.97 (95% CI,.70-1.36) for CHG.
Conclusions. Personal hygiene and education measures, including once-weekly use of chlorhexidine body wash, did not prevent overall SSTI or MRSA SSTI in a high-risk population of military trainees.
C1 [Ellis, Michael W.] Uniformed Serv Univ Hlth Sci, Dept Med, Bethesda, MD 20814 USA.
[Schlett, Carey D.; Millar, Eugene V.; Crawford, Katrina B.; Morrison-Rodriguez, Stephanie M.; Tribble, David R.] Uniformed Serv Univ Hlth Sci, Dept Prevent Med & Biometr, Infect Dis Clin Res Program, Bethesda, MD 20814 USA.
[Wilkins, Kenneth J.] NIDDK, NIH, Bethesda, MD 20892 USA.
[Pacha, Laura A.] US Army Publ Hlth Command, Army Inst Publ Hlth, Aberdeen Proving Ground, MD USA.
[Gorwitz, Rachel J.] Ctr Dis Control & Prevent, Atlanta, GA USA.
[Lanier, Jeffrey B.] Martin Army Community Hosp, Ft Benning, GA USA.
RP Ellis, MW (reprint author), Uniformed Serv Univ Hlth Sci, Dept Med, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA.
EM michael.ellis@usuhs.edu
FU Infectious Disease Clinical Research Program, a DoD program through the
Uniformed Services University of the Health Sciences; National Institute
of Allergy and Infectious Diseases, National Institutes of Health
[Y1-AI-5072]; CDC, National Center for Emerging and Zoonotic Infectious
Diseases, Division of Healthcare Quality Promotion [09FED914272]; DoD
Global Emerging Infections Surveillance program [C0366-11-HS]
FX The work was supported by the Infectious Disease Clinical Research
Program, a DoD program executed through the Uniformed Services
University of the Health Sciences. This project has been funded in
whole, or in part, with federal funds from the National Institute of
Allergy and Infectious Diseases, National Institutes of Health
(Interagency Agreement Y1-AI-5072). Additional funding was provided by
CDC, National Center for Emerging and Zoonotic Infectious Diseases,
Division of Healthcare Quality Promotion (Interagency Agreement
(09FED914272 to M. W. E.), and the DoD Global Emerging Infections
Surveillance program (C0366-11-HS to M. W. E.).
NR 38
TC 15
Z9 15
U1 0
U2 5
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 1058-4838
EI 1537-6591
J9 CLIN INFECT DIS
JI Clin. Infect. Dis.
PD JUN 1
PY 2014
VL 58
IS 11
BP 1540
EP 1548
DI 10.1093/cid/ciu166
PG 9
WC Immunology; Infectious Diseases; Microbiology
SC Immunology; Infectious Diseases; Microbiology
GA AI7AL
UT WOS:000337031200009
PM 24633684
ER
PT J
AU Briggs, MJ
Silver, AL
Kopp, PJ
AF Briggs, Michael J.
Silver, Andrew L.
Kopp, Paul J.
TI PROBABILISTIC MODEL FOR PREDICTING SHIP UNDERKEEL CLEARANCE: FIELD AND
LABORATORY VALIDATION
SO COASTAL ENGINEERING JOURNAL
LA English
DT Article
DE Deep-draft ships; deep-draft channel design; underkeel clearance;
probabilistic channel design; wave-induced ship motions; GPS ship
measurements; physical models; model validation
AB This paper presents validation comparisons between field and laboratory measurements and a new probabilistic model for predicting ship underkeel clearance (UKC). Prototype ship motions and environmental data were obtained in May 1999 in the deep-draft entrance channel at Barbers Point, HI. These field measurements were reproduced in controlled laboratory studies in 2000 and 2002 with a model of the World Utility (WU) bulk carrier. These measurements constitute some of the data being used to validate the Corps's Channel Analysis and Design Evaluation Tool (CADET), a suite of programs to determine the optimum dredge depth for entrance channels. In general, the CADET predictions matched the field and laboratory measurements within cm-accuracy for wave heights that ranged from 45 cm to 75 cm.
C1 [Briggs, Michael J.] Briggs Grp LLC, Vicksburg, MS 39180 USA.
[Silver, Andrew L.; Kopp, Paul J.] Naval Surface Warfare Ctr, Carderock Div, Seakeeping Dept, West Bethesda, MD 20817 USA.
[Briggs, Michael J.] US Army Engineer Res & Dev Ctr, Coastal & Hydraul Lab, CEERD HN HH, Vicksburg, MS 39180 USA.
RP Briggs, MJ (reprint author), Briggs Grp LLC, Vicksburg, MS 39180 USA.
EM briggsm1@cablelynx.com
NR 22
TC 0
Z9 0
U1 0
U2 5
PU WORLD SCIENTIFIC PUBL CO PTE LTD
PI SINGAPORE
PA 5 TOH TUCK LINK, SINGAPORE 596224, SINGAPORE
SN 0578-5634
EI 1793-6292
J9 COAST ENG J
JI Coast Eng. J.
PD JUN
PY 2014
VL 56
IS 2
AR 1450010
DI 10.1142/S0578563414500107
PG 31
WC Engineering, Civil; Engineering, Ocean
SC Engineering
GA AI6GJ
UT WOS:000336969800004
ER
PT J
AU Jin, X
Pybus, BS
Marcsisin, SR
Logan, T
Luong, TL
Sousa, J
Matlock, N
Collazo, V
Asher, C
Carroll, D
Olmeda, R
Walker, LA
Kozar, MP
Melendez, V
AF Jin, X.
Pybus, B. S.
Marcsisin, S. R.
Logan, T.
Luong, T. L.
Sousa, J.
Matlock, N.
Collazo, V.
Asher, C.
Carroll, D.
Olmeda, R.
Walker, L. A.
Kozar, M. P.
Melendez, V.
TI An LC-MS based study of the metabolic profile of primaquine, an
8-aminoquinoline antiparasitic drug, with an in vitro primary human
hepatocyte culture model
SO EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS
LA English
DT Article
DE Metabolism; Transport; Pharmacogenomics
ID RESISTANCE; CLEARANCE
AB The 8-aminoquinoline drug primaquine (PQ) is currently the only drug in use against the persistent malaria caused by the hypnozoite-forming strains P. vivax and P. ovale. However, despite decades of research, its complete metabolic profile is still poorly understood. In the present study, the metabolism of PQ was evaluated by incubating the drug with pooled human hepatocytes cultured in vitro as well as with recombinant cytochrome P450 (CYP) isoenzymes, monoamine oxidases (MAO), and flavin-containing monooxygenases (FMO). Targeted LC-MS/MS analysis of hepatocyte incubations using chemical inhibitors indicated that PQ was predominantly metabolized by CYPs 3A4, 1A2 and 2D6, MAO-A, -B and FMO-3. Confirmation of these results was sought by incubation of PQ with the corresponding recombinant enzymes. Small amounts of carboxyprimaquine (CPQ), the major observed PQ metabolite in vivo, were detected in recombinant MAO-A incubations along with another peak at m/z 261, and no significant formation of CPQ with any other recombinant enzymes was observed. Incubations with all recombinant enzymes identified as potentially active towards PQ from the hepatocyte-based assay resulted in significant parent loss over the course of 1 h. These results suggest that several enzymes, including CYPs in combination with FMOs and MAOs, play a role in the overall metabolism of PQ and indicate a major role for MAO-A. Future studies to elucidate the potential role in cytotoxicity and/or efficacy of the PQ metabolite observed at m/z 261, as observed in MAO-A isoenzyme studies, are needed.
C1 [Jin, X.; Pybus, B. S.; Marcsisin, S. R.; Logan, T.; Luong, T. L.; Sousa, J.; Matlock, N.; Collazo, V.; Asher, C.; Carroll, D.; Olmeda, R.; Kozar, M. P.; Melendez, V.] Walter Reed Army Inst Res, Dept Drug Dev, Div Expt Therapeut, Silver Spring, MD 20910 USA.
[Walker, L. A.] Univ Mississippi, Sch Pharm, Natl Ctr Nat Prod Res, University, MS 38677 USA.
RP Pybus, BS (reprint author), Walter Reed Army Inst Res, Dept Drug Dev, Div Expt Therapeut, 503 Robert Grant Ave, Silver Spring, MD 20910 USA.
EM brandon.pybus@us.army.mil
FU US Army Medical Research and Materiel Command (USAMRMC); Telemedicine
and Advanced Technology Research Center (TATRC), at Fort Detrick, MD
[W81-XWH-07-2-0095]
FX This research and development project is supported by a grant to the
University of Mississippi, and was awarded and administered by the US
Army Medical Research and Materiel Command (USAMRMC) and the
Telemedicine and Advanced Technology Research Center (TATRC), at Fort
Detrick, MD, under award number: W81-XWH-07-2-0095. The views, opinions
and/or findings contained in this presentation are those of the
author(s) and do not necessarily reflect the views of the Department of
Defense and should not be construed as an official DoD/Army position,
policy or decision unless so designated by other documentation. No
official endorsement should be made.
NR 19
TC 8
Z9 8
U1 1
U2 14
PU SPRINGER FRANCE
PI PARIS
PA 22 RUE DE PALESTRO, PARIS, 75002, FRANCE
SN 0378-7966
EI 2107-0180
J9 EUR J DRUG METAB PH
JI Eur. J. Drug Metabol. Pharmacokinet.
PD JUN
PY 2014
VL 39
IS 2
BP 139
EP 146
DI 10.1007/s13318-013-0139-8
PG 8
WC Pharmacology & Pharmacy
SC Pharmacology & Pharmacy
GA AI7GG
UT WOS:000337052600009
PM 23797843
ER
PT J
AU Inouye, KAS
Bisch, FC
Elsalanty, ME
Zakhary, I
Khashaba, RM
Borke, JL
AF Inouye, Kimberly Ann S.
Bisch, Frederick C.
Elsalanty, Mohammed E.
Zakhary, Ibrahim
Khashaba, Rania M.
Borke, James L.
TI Effect of Metformin on Periimplant Wound Healing in a Rat Model of Type
2 Diabetes
SO IMPLANT DENTISTRY
LA English
DT Article
DE type 2 diabetes; dental implants; metformin; rat model
ID ADVANCED GLYCATION ENDPRODUCTS; DENTAL IMPLANTS; OSTEOBLASTIC CELLS;
GLYCEMIC CONTROL; BONE-FORMATION; MELLITUS; OSSEOINTEGRATION; IMPACT;
MECHANISMS; SURVIVAL
AB Purpose: To investigate the effects of hyperglycemia and metformin (a popular biguanide antidiabetic) on periimplant healing.
Methods: Thirty-six male rats were assigned to 3 groups: (1) nondiabetic Wistar-Kyoto rats (controls), (2) Goto-Kakizaki (GK) spontaneously diabetic rats (GK group), and (3) GK rats were fed metformin (100 mg/kg body weight per day) in their water for 4 weeks (GK + Met group). The right maxillary first molars were extracted and sites were allowed 1 month to heal. Titanium implants (1 x 3 mm) were placed in healed extraction sites. Six rats from each group were analyzed at weeks 1 and 4 by micro computed tomography for bone/implant contact ratio, percent bone volume, trabecular number, and bone mineral density. Blood was also analyzed for glucose, HbA1c, and pyridinoline (PYD).
Results: At week 1, glucose levels in the GK-Met rats were high, and all bone parameters were similar to GK rats (lower bone parameters and higher PYD than controls). At week 4, glucose levels in the GK-Met rats and all parameters were similar to controls.
Conclusions: Hyperglycemic GK type 2 diabetic rats showed improved blood glucose and wound healing around oral implants after metformin administration.
C1 [Inouye, Kimberly Ann S.; Elsalanty, Mohammed E.; Zakhary, Ibrahim; Borke, James L.] Georgia Regents Univ, Dept Oral Biol, Augusta, GA USA.
[Inouye, Kimberly Ann S.; Bisch, Frederick C.] Ft Gordon, US Army Adv Educ Program Periodont, Augusta, GA USA.
[Khashaba, Rania M.] Misr Int Univ, Dept Biomat, Cairo, Egypt.
[Borke, James L.] Western Univ Hlth Sci, Coll Dent Med, Pomona, CA 91766 USA.
RP Borke, JL (reprint author), Western Univ Hlth Sci, Coll Dent Med, 309 E Second St, Pomona, CA 91766 USA.
EM jborke@westernu.edu
FU United States Army Advanced Education Program in Periodontics, Fort
Gordon, Augusta, GA
FX This work was supported by the United States Army Advanced Education
Program in Periodontics, Fort Gordon, Augusta, GA. The authors claim to
have no financial interest, either directly or indirectly, in the
products or information listed in the article.
NR 35
TC 4
Z9 5
U1 0
U2 6
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1056-6163
J9 IMPLANT DENT
JI Implant Dent.
PD JUN
PY 2014
VL 23
IS 3
BP 319
EP 327
DI 10.1097/ID.0000000000000069
PG 9
WC Dentistry, Oral Surgery & Medicine
SC Dentistry, Oral Surgery & Medicine
GA AI5ID
UT WOS:000336898200016
PM 24776941
ER
PT J
AU Clayton, JD
AF Clayton, J. D.
TI Analysis of shock compression of strong single crystals with logarithmic
thermoelastic-plastic theory
SO INTERNATIONAL JOURNAL OF ENGINEERING SCIENCE
LA English
DT Article
DE Shock physics; Elasticity; Plasticity; Finite strain; Crystals
ID NONLINEAR ANISOTROPIC DESCRIPTION; FINITE DEFORMATION PLASTICITY;
EQUATION-OF-STATE; WAVE-PROPAGATION; ELASTIC-CONSTANTS; THERMOMECHANICAL
RESPONSE; DYNAMIC PLASTICITY; ANHARMONIC THEORY; BRITTLE MATERIALS;
THIRD-ORDER
AB A finite strain theory is developed for anisotropic single crystals undergoing shock loading. Inelastic deformation may arise from dislocation slip, twinning, or fracture and crack sliding. Internal energy can generally depend on a logarithmic measure of finite elastic strain, entropy, and an internal variable associated with defect accumulation. A closed form analytical solution is derived for the planar shock response in the thermoelastic regime, at axial stresses up to the Hugoniot elastic limit. In the plastic regime, for highly symmetric orientations and rate independent shear strength, the Rankine-Hugoniot conditions and constitutive relations can be reduced to a set of algebraic equations that can be solved for the material response. The theory is applied towards planar shock loading of single crystals of sapphire, diamond, and quartz. Logarithmic elasticity is demonstrated to be more accurate (i.e., require fewer higher-order elastic constants) than Lagrangian or Eulerian theories for sapphire, diamond, and Z-cut quartz. Results provide new insight into criteria for initiation of twinning, slip, and/or fracture in these materials as well as their strength degradation when shocked at increasingly higher pressures above the Hugoniot elastic limit. Published by Elsevier Ltd.
C1 US Army, Res Lab, RDRL WMP C, Impact Phys, Aberdeen Proving Ground, MD 21005 USA.
RP Clayton, JD (reprint author), US Army, Res Lab, RDRL WMP C, Impact Phys, Aberdeen Proving Ground, MD 21005 USA.
EM john.d.clayton1.civ@mail.mil
RI Clayton, John/C-7760-2009
NR 71
TC 12
Z9 12
U1 0
U2 19
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0020-7225
EI 1879-2197
J9 INT J ENG SCI
JI Int. J. Eng. Sci.
PD JUN
PY 2014
VL 79
BP 1
EP 20
DI 10.1016/j.ijengsci.2014.02.016
PG 20
WC Engineering, Multidisciplinary
SC Engineering
GA AI6TD
UT WOS:000337009000001
ER
PT J
AU Bear, KA
Solomon, BD
Antonini, S
Arnhold, IJP
Franca, MM
Gerkes, EH
Grange, DK
Hadley, DW
Jaaskelainen, J
Paulo, SS
Rump, P
Stratakis, CA
Thompson, EM
Willis, M
Winder, TL
Jorge, AAL
Roessler, E
Muenke, M
AF Bear, Kelly A.
Solomon, Benjamin D.
Antonini, Sonir
Arnhold, Ivo J. P.
Franca, Marcela M.
Gerkes, Erica H.
Grange, Dorothy K.
Hadley, Donald W.
Jaaskelainen, Jarmo
Paulo, Sabrina S.
Rump, Patrick
Stratakis, Constantine A.
Thompson, Elizabeth M.
Willis, Mary
Winder, Thomas L.
Jorge, Alexander A. L.
Roessler, Erich
Muenke, Maximilian
TI Pathogenic mutations in GLI2 cause a specific phenotype that is distinct
from holoprosencephaly
SO JOURNAL OF MEDICAL GENETICS
LA English
DT Article
ID SONIC-HEDGEHOG; SPECTRUM; HYPOPITUITARISM; INDIVIDUALS; FREQUENCY;
VARIANTS; DEFECTS; DISEASE; GENE; ZIC2
AB Background Mutations in GLI2 have been associated with holoprosencephaly (HPE), a neuroanatomic anomaly resulting from incomplete cleavage of the developing forebrain, and an HPE-like phenotype involving pituitary anomalies and polydactyly.
Objective To characterise the genotypic and phenotypic findings in individuals with GLI2 variants and clarify clinical findings in individuals with loss-of-function mutations.
Methods Through the National Institutes of Health and collaborating centres, similar to 400 individuals with HPE spectrum disorders, endocrine disorders or craniofacial anomalies were screened for GLI2 mutations. Results were combined with all published cases. We compared the clinical and molecular features of individuals with truncating mutations to individuals with variants of unknown significance (defined as not resulting in protein truncation, reported in normal controls and/or deemed unlikely to be pathogenic by functional prediction software).
Results 112 individuals with variants in GLI2 were identified, with 43 having truncating mutations. Individuals with truncating mutations were more likely to have both pituitary anomalies and polydactyly versus those with variants of unknown significance (p<0.0001 by Fisher's exact test); only 1 of 43 had frank HPE. These individuals were more likely to have recognised penetrance (polydactyly or pituitary anomalies or both) than those without truncating mutations (p=0.0036 by Fisher's exact test). A common facial phenotype was seen in individuals (with midface hypoplasia, cleft lip/palate and hypotelorism) with truncating mutations.
Conclusions Individuals with truncating mutations in GLI2 typically present with pituitary anomalies, polydactyly and subtle facial features rather than HPE. This will be helpful in screening populations for GLI2 mutations and for counselling affected patients.
C1 [Bear, Kelly A.; Solomon, Benjamin D.; Hadley, Donald W.; Roessler, Erich; Muenke, Maximilian] NHGRI, Med Genet Branch, NIH, Bethesda, MD 20892 USA.
[Bear, Kelly A.] Tripler Army Med Ctr, Dept Pediat, Honolulu, HI 96859 USA.
[Solomon, Benjamin D.] Inova Hlth Syst, Inova Translat Med Inst, Div Med Genom, Falls Church, VA USA.
[Solomon, Benjamin D.] Inova Hlth Syst, Inova Childrens Hosp, Dept Pediat, Falls Church, VA USA.
[Antonini, Sonir; Paulo, Sabrina S.] Univ Sao Paulo, Sch Med Ribeirao Preto, Dept Pediat, Sao Paulo, Brazil.
[Arnhold, Ivo J. P.; Franca, Marcela M.] Univ Sao Paulo, Unidade Endocrinol Desenvolvimento, Lab Hormonios & Genet Mol LIM 42, Hosp Clin,Fac Med,Disciplina Endocrinol, Sao Paulo, Brazil.
[Gerkes, Erica H.; Rump, Patrick] Univ Groningen, Univ Med Ctr Groningen, Dept Genet, Groningen, Netherlands.
[Grange, Dorothy K.] Washington Univ Schl Mdcn, St Louis, MO USA.
[Jaaskelainen, Jarmo] Univ Eastern Finland, Dept Pediat, Kuopio, Finland.
[Jaaskelainen, Jarmo] Kuopio Univ Hosp, SF-70210 Kuopio, Finland.
[Stratakis, Constantine A.] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, NIH, Bethesda, MD USA.
[Thompson, Elizabeth M.] Womens & Childrens Hosp, South Australian Clin Genet Serv, SA Pathol, Adelaide, SA, Australia.
[Thompson, Elizabeth M.] Univ Adelaide, Dept Paediat, Adelaide, SA, Australia.
[Willis, Mary] Naval Med Ctr, Dept Pediat, San Diego, CA USA.
[Winder, Thomas L.] Prevent Genet, Marshfield, WI USA.
[Jorge, Alexander A. L.] Univ Sao Paulo, Unidade Endocrinol Genet, LIM 25, Disciplina Endocrinol,Hosp Clin,Fac Med, Sao Paulo, Brazil.
RP Muenke, M (reprint author), NHGRI, Med Genet Branch, 35 Convent Dr,Bldg 35,Room 1B 203, Bethesda, MD 20892 USA.
EM mamuenke@mail.nih.gov
RI Jorge, Alexander/C-7697-2012; ARNHOLD, IVO/D-2672-2012; Antonini, Sonir
/J-5264-2015
OI Jorge, Alexander/0000-0003-2567-7360;
FU Division of Intramural Research, National Human Genome Research
Institute, National Institutes of Health, Department of Health and Human
Services, USA
FX This research was supported by the Division of Intramural Research,
National Human Genome Research Institute, National Institutes of Health,
Department of Health and Human Services, USA. Pertaining to KAB, the
views expressed in this publication are those of the author and do not
reflect the official policy or position of the Department of the Army,
Department of Defense, or the US Government. Pertaining to MW, the views
expressed in this article are those of the author and do not necessarily
reflect the official policy or position of the Department of the Navy,
Department of Defense or the United States Government. The authors would
like to express their gratitude to the patients and families involved.
NR 28
TC 11
Z9 11
U1 0
U2 3
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 0022-2593
EI 1468-6244
J9 J MED GENET
JI J. Med. Genet.
PD JUN
PY 2014
VL 51
IS 6
BP 413
EP 418
DI 10.1136/jmedgenet-2013-102249
PG 6
WC Genetics & Heredity
SC Genetics & Heredity
GA AI4NE
UT WOS:000336841300008
PM 24744436
ER
PT J
AU Friedrich, TL
Vessey, WB
Schuelke, MJ
Mumford, MD
Yammarino, FJ
Ruark, GA
AF Friedrich, Tamara L.
Vessey, William B.
Schuelke, Matthew J.
Mumford, Michael D.
Yammarino, Francis J.
Ruark, Gregory A.
TI Collectivistic leadership and George C. Marshall: A historiometric
analysis of career events
SO LEADERSHIP QUARTERLY
LA English
DT Article
DE Collective leadership; Military leadership; Historiometric methods;
Leadership in teams; Leadership in networks
ID SHARED LEADERSHIP; MEMBER EXCHANGE; TEAM EFFECTIVENESS; PERFORMANCE;
ORGANIZATIONS; PERSPECTIVE; SCIENCE; WORLD; TIES; CONSEQUENCES
AB Many of the prevailing approaches to understanding leadership assume that leadership operates as an individual-level phenomenon, in which one person takes on the role of a leader. However, a number of recently developed leadership models now describe leadership as a shared process. These collectivistic theories present leadership as a dynamic process in which a leader may selectively utilize the skills of followers and distribute elements of the leadership role among these followers as the situation demands. In this study, we conduct an investigation into the viability of core elements of the collectivistic theories through a historiometric analysis of events from the career of a notable leader, George C. Marshall. One hundred and two events from Marshall's career were identified from historical biographies and were then content coded and analyzed with regard to the components of a collectivistic leadership model. The results of this historiometric analysis indicated that there are key antecedents to collectivistic leadership and that the use of this form of leadership can result in positive team outcomes. (C) 2013 Elsevier Inc. All rights reserved.
C1 [Friedrich, Tamara L.] Univ Warwick, Coventry CV4 7AL, W Midlands, England.
[Vessey, William B.; Mumford, Michael D.] Univ Oklahoma, Norman, OK 73019 USA.
[Schuelke, Matthew J.] Air Force Res Lab, Wright Patterson AFB, OH USA.
[Yammarino, Francis J.] SUNY Binghamton, Binghamton, NY 13902 USA.
[Ruark, Gregory A.] US Army Res Inst, Arlington, VA USA.
RP Friedrich, TL (reprint author), Univ Warwick, Warwick Business Sch, Coventry CV4 7AL, W Midlands, England.
EM tamara.friedrich@wbs.ac.uk
NR 90
TC 7
Z9 7
U1 5
U2 26
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1048-9843
EI 1873-3409
J9 LEADERSHIP QUART
JI Leadersh. Q.
PD JUN
PY 2014
VL 25
IS 3
BP 449
EP 467
DI 10.1016/j.leaqua.2013.10.012
PG 19
WC Psychology, Applied; Management
SC Psychology; Business & Economics
GA AI5ER
UT WOS:000336888700003
ER
PT J
AU Kaplan, S
Cortina, J
Ruark, G
LaPort, K
Nicolaides, V
AF Kaplan, Seth
Cortina, Jose
Ruark, Gregory
LaPort, Kate
Nicolaides, Vias
TI The role of organizational leaders in employee emotion management: A
theoretical model
SO LEADERSHIP QUARTERLY
LA English
DT Article
DE Emotion; Affect; Leadership; Emotion management; Performance
ID AFFECTIVE STATES; TRANSFORMATIONAL LEADERSHIP; ABUSIVE SUPERVISION; WORK
ORGANIZATIONS; JOB-PERFORMANCE; INTELLIGENCE; WORKPLACE; BEHAVIOR;
SUPPORT; MOOD
AB The actions of organizational leaders are important determinants of the emergence, management, and consequences of employee emotional experience. However, the nature and dimensionality of leader emotion management and the behaviors that constitute such management are largely unknown. The authors present a comprehensive, theoretically-derived model of leader emotion management which clarifies the nature of emotion management and its role in leadership. This model also delineates the knowledge and skill-based antecedents of emotion management and the consequences of such management Specifically, we propose linkages between particular KSAOs and specific emotion management dimensions and between those dimensions and particular individual and organizational outcomes. The model is meant to serve as a framework to guide empirical efforts in investigating the nature and correlates of leader emotion management. (C) 2013 Elsevier Inc. All rights reserved.
C1 [Kaplan, Seth; Cortina, Jose; Nicolaides, Vias] George Mason Univ, Fairfax, VA 22030 USA.
[Ruark, Gregory; LaPort, Kate] US Army Res Inst Behav & Social Sci, Arlington, VA USA.
RP Kaplan, S (reprint author), George Mason Univ, Dept Psychol, 4400 Univ Dr,MSN 3 F5, Fairfax, VA 22030 USA.
EM Skaplan1@gmu.edu
NR 134
TC 7
Z9 9
U1 9
U2 53
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1048-9843
EI 1873-3409
J9 LEADERSHIP QUART
JI Leadersh. Q.
PD JUN
PY 2014
VL 25
IS 3
BP 563
EP 580
DI 10.1016/j.leaqua.2013.11.015
PG 18
WC Psychology, Applied; Management
SC Psychology; Business & Economics
GA AI5ER
UT WOS:000336888700009
ER
PT J
AU Burgess, E
AF Burgess, Edwin
TI I Heard My Country Calling: A Memoir
SO LIBRARY JOURNAL
LA English
DT Book Review
C1 [Burgess, Edwin] US Army, Combined Arms Res Lib, Ft Leavenworth, KS 66027 USA.
RP Burgess, E (reprint author), US Army, Combined Arms Res Lib, Ft Leavenworth, KS 66027 USA.
NR 1
TC 0
Z9 0
U1 0
U2 1
PU REED BUSINESS INFORMATION
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010 USA
SN 0363-0277
J9 LIBR J
JI Libr. J.
PD JUN 1
PY 2014
VL 139
IS 10
BP 120
EP 120
PG 1
WC Information Science & Library Science
SC Information Science & Library Science
GA AI4JD
UT WOS:000336830600197
ER
PT J
AU Bailey, D
AF Bailey, David
TI Solar-powered cathodic protection safeguards water tanks in remote area
SO MATERIALS PERFORMANCE
LA English
DT News Item
C1 ERDC CERL, Champaign, IL 61822 USA.
RP Bailey, D (reprint author), ERDC CERL, Champaign, IL 61822 USA.
EM david.m.bailey@usace.army.mil
NR 0
TC 0
Z9 0
U1 1
U2 3
PU NATL ASSOC CORROSION ENG
PI HOUSTON
PA 1440 SOUTH CREEK DRIVE, HOUSTON, TX 77084-4906 USA
SN 0094-1492
J9 MATER PERFORMANCE
JI Mater. Perform.
PD JUN
PY 2014
VL 53
IS 6
BP 17
EP 18
PG 2
WC Materials Science, Characterization & Testing
SC Materials Science
GA AI5WO
UT WOS:000336940400003
ER
PT J
AU Linkov, I
Bridges, T
Creutzig, F
Decker, J
Fox-Lent, C
Kroger, W
Lambert, JH
Levermann, A
Montreuil, B
Nathwani, J
Nyer, R
Renn, O
Scharte, B
Scheffler, A
Schreurs, M
Thiel-Clemen, T
AF Linkov, Igor
Bridges, Todd
Creutzig, Felix
Decker, Jennifer
Fox-Lent, Cate
Kroeger, Wolfgang
Lambert, James H.
Levermann, Anders
Montreuil, Benoit
Nathwani, Jatin
Nyer, Raymond
Renn, Ortwin
Scharte, Benjamin
Scheffler, Alexander
Schreurs, Miranda
Thiel-Clemen, Thomas
TI Changing the resilience paradigm
SO NATURE CLIMATE CHANGE
LA English
DT Editorial Material
ID SYSTEMS; RISK
C1 [Linkov, Igor; Fox-Lent, Cate] US Army, Corps Engineers, Engineer Res & Dev Ctr, Environm Lab, Concord, MA 01742 USA.
[Bridges, Todd] US Army, Corps Engineers, Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA.
[Creutzig, Felix] Mercator Res Inst Global Commons & Climate Chang, D-10829 Berlin, Germany.
[Decker, Jennifer] Embassy Canada, D-10117 Berlin, Germany.
[Kroeger, Wolfgang] Swiss Fed Inst Technol Zurich ETH, CH-8092 Zurich, Switzerland.
[Lambert, James H.] Univ Virginia, Charlottesville, VA 22903 USA.
[Levermann, Anders] Potsdam Inst Climate Impact Res, D-14191 Potsdam, Germany.
[Montreuil, Benoit] Univ Laval, Quebec City, PQ G1V 0A6, Canada.
[Nathwani, Jatin] Univ Waterloo, Waterloo, ON N2L 3G1, Canada.
[Nyer, Raymond] RNC Conseil, F-92200 Neuilly Sur Seine, France.
[Nyer, Raymond] Ecole Cent Paris, F-92200 Neuilly Sur Seine, France.
[Renn, Ortwin] Univ Stuttgart, D-70174 Stuttgart, Germany.
[Scharte, Benjamin] Fraunhofer Inst High Speed Dynam, D-79104 Freiburg, Germany.
[Scheffler, Alexander] Hamburg Univ Technol, D-21073 Hamburg, Germany.
[Schreurs, Miranda] Free Univ Berlin, D-14195 Berlin, Germany.
[Thiel-Clemen, Thomas] Hamburg Univ Appl Sci, D-21033 Hamburg, Germany.
RP Linkov, I (reprint author), US Army, Corps Engineers, Engineer Res & Dev Ctr, Environm Lab, 696 Virginia Rd, Concord, MA 01742 USA.
EM igor.linkov@usace.army.mil
RI Levermann, Anders/G-4666-2011;
OI Levermann, Anders/0000-0003-4432-4704; Renn, Ortwin/0000-0002-4681-1752
NR 12
TC 23
Z9 35
U1 2
U2 33
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1758-678X
EI 1758-6798
J9 NAT CLIM CHANGE
JI Nat. Clim. Chang.
PD JUN
PY 2014
VL 4
IS 6
BP 407
EP 409
PG 3
WC Environmental Sciences; Environmental Studies; Meteorology & Atmospheric
Sciences
SC Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences
GA AI8EC
UT WOS:000337138700005
ER
PT J
AU Torres, LN
Sondeen, J
Salgado, C
Valdez, C
Dubick, MA
Filho, IT
AF Torres, L. N.
Sondeen, J.
Salgado, C.
Valdez, C.
Dubick, M. A.
Filho, I. Torres
TI ENDOTHELIAL GLYCOCALYX (EG) AFTER SEVERE HEMORRHAGIC SHOCK (HS) FOLLOWED
BY PLASMA VOLUME EXPANSION WITH NORMAL SALINE
SO SHOCK
LA English
DT Meeting Abstract
CT 37th Annual Conference of the Shock-Society on Shock
CY JUN 07-10, 2014
CL Charlotte, NC
SP Shock Soc
C1 [Torres, L. N.; Sondeen, J.; Salgado, C.; Valdez, C.; Dubick, M. A.; Filho, I. Torres] US Army Inst Surg Res, San Antonio, TX USA.
NR 0
TC 1
Z9 1
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1073-2322
EI 1540-0514
J9 SHOCK
JI Shock
PD JUN
PY 2014
VL 41
SU 2
BP 26
EP 26
PG 1
WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease
SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System
& Cardiology
GA AI6ET
UT WOS:000336964600041
ER
PT J
AU Wu, X
Darlington, DN
Cap, AP
AF Wu, X.
Darlington, D. N.
Cap, A. P.
TI FIBRINOLYTIC ACTIVITY IN PLASMA AFTER POLYTRAUMA AND HEMORRHGE IN RATS
SO SHOCK
LA English
DT Meeting Abstract
CT 37th Annual Conference of the Shock-Society on Shock
CY JUN 07-10, 2014
CL Charlotte, NC
SP Shock Soc
C1 [Wu, X.; Darlington, D. N.; Cap, A. P.] US Army Inst Surg Res, Ft Sam Houston, TX USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1073-2322
EI 1540-0514
J9 SHOCK
JI Shock
PD JUN
PY 2014
VL 41
SU 2
BP 52
EP 52
PG 1
WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease
SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System
& Cardiology
GA AI6ET
UT WOS:000336964600114
ER
PT J
AU Wu, X
Darlington, DN
Cap, AP
AF Wu, X.
Darlington, D. N.
Cap, A. P.
TI THROMBIN INHIBITION AFTER POLYTRAUMA AND HEMORRHAGE IN RATS
SO SHOCK
LA English
DT Meeting Abstract
CT 37th Annual Conference of the Shock-Society on Shock
CY JUN 07-10, 2014
CL Charlotte, NC
SP Shock Soc
C1 [Wu, X.; Darlington, D. N.; Cap, A. P.] US Army Inst Surg Res, Ft Sam Houston, TX USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1073-2322
EI 1540-0514
J9 SHOCK
JI Shock
PD JUN
PY 2014
VL 41
SU 2
BP 62
EP 62
PG 1
WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease
SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System
& Cardiology
GA AI6ET
UT WOS:000336964600141
ER
PT J
AU Darlington, DN
Keesee, JD
Wu, X
Cap, AP
AF Darlington, D. N.
Keesee, J. D.
Wu, X.
Cap, A. P.
TI PLATELET FUNCTION AFTER POLYTRAUMA AND HEMORRHAGE IN RATS
SO SHOCK
LA English
DT Meeting Abstract
CT 37th Annual Conference of the Shock-Society on Shock
CY JUN 07-10, 2014
CL Charlotte, NC
SP Shock Soc
C1 [Darlington, D. N.; Keesee, J. D.; Wu, X.; Cap, A. P.] US Army Inst Surg Res, Ft Sam Houston, TX USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1073-2322
EI 1540-0514
J9 SHOCK
JI Shock
PD JUN
PY 2014
VL 41
SU 2
BP 64
EP 65
PG 2
WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease
SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System
& Cardiology
GA AI6ET
UT WOS:000336964600148
ER
PT J
AU Dubick, MA
Li, Y
Grubbs, DL
Barr, JL
Lucca, JJD
AF Dubick, M. A.
Li, Y.
Grubbs, D. L.
Barr, J. L.
Lucca, J. J. Dalle
TI INFLAMMATORY RESPONSES IN BRAIN FROM SWINE SUBJECTED TO TRAUMATIC
HEMORRHAGE AND TREATED WITH A C1 INHIBITOR
SO SHOCK
LA English
DT Meeting Abstract
CT 37th Annual Conference of the Shock-Society on Shock
CY JUN 07-10, 2014
CL Charlotte, NC
SP Shock Soc
C1 [Dubick, M. A.; Li, Y.; Grubbs, D. L.; Barr, J. L.; Lucca, J. J. Dalle] US Army Inst Surg Res, San Antonio, TX USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1073-2322
EI 1540-0514
J9 SHOCK
JI Shock
PD JUN
PY 2014
VL 41
SU 2
BP 65
EP 65
PG 1
WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease
SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System
& Cardiology
GA AI6ET
UT WOS:000336964600149
ER
PT J
AU Meyer, RR
Bhattacharjee, M
Varghese, N
Sharma, M
Pusateri, AE
Brownstein, BH
AF Meyer, R. R.
Bhattacharjee, M.
Varghese, N.
Sharma, M.
Pusateri, A. E.
Brownstein, B. H.
TI SERIAL ANALYSIS OF TRAUMA PATIENT LEUKOCYTE MRNAS ENCODING PROTEINS
INVOLVED IN COAGULATION
SO SHOCK
LA English
DT Meeting Abstract
CT 37th Annual Conference of the Shock-Society on Shock
CY JUN 07-10, 2014
CL Charlotte, NC
SP Shock Soc
C1 [Meyer, R. R.; Bhattacharjee, M.; Varghese, N.; Sharma, M.; Brownstein, B. H.] Washington Univ, Sch Med, St Louis, MO USA.
[Pusateri, A. E.] US Army Med Res & Mat Command, Ft Detrick, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1073-2322
EI 1540-0514
J9 SHOCK
JI Shock
PD JUN
PY 2014
VL 41
SU 2
BP 80
EP 80
PG 1
WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease
SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System
& Cardiology
GA AI6ET
UT WOS:000336964600193
ER
PT J
AU Wu, X
Darlington, DN
Schwacha, MG
Cap, AP
AF Wu, X.
Darlington, D. N.
Schwacha, M. G.
Cap, A. P.
TI THE DEVELOPMENT OF ACUTE LUNG INJURY AFTER POLYTRAUMA AND HEMORRHAGE IN
RATS
SO SHOCK
LA English
DT Meeting Abstract
CT 37th Annual Conference of the Shock-Society on Shock
CY JUN 07-10, 2014
CL Charlotte, NC
SP Shock Soc
C1 [Wu, X.; Darlington, D. N.; Schwacha, M. G.; Cap, A. P.] US Army Inst Surg Res, Ft Sam Houston, TX USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1073-2322
EI 1540-0514
J9 SHOCK
JI Shock
PD JUN
PY 2014
VL 41
SU 2
BP 90
EP 90
PG 1
WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease
SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System
& Cardiology
GA AI6ET
UT WOS:000336964600220
ER
PT J
AU Martini, WZ
Chung, KK
Dubick, MA
AF Martini, W. Z.
Chung, K. K.
Dubick, M. A.
TI COMPARISONS OF NORMAL SALINE AND LACTATED RINGER'S IN NORMAL AND
HYPOTENSIVE RESUSCITATION IN PIGS AFTER HEMORRHAGIC SHOCK
SO SHOCK
LA English
DT Meeting Abstract
CT 37th Annual Conference of the Shock-Society on Shock
CY JUN 07-10, 2014
CL Charlotte, NC
SP Shock Soc
C1 [Martini, W. Z.; Chung, K. K.; Dubick, M. A.] US Army Inst Surg Res, Ft Sam Houston, TX USA.
NR 0
TC 0
Z9 0
U1 1
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1073-2322
EI 1540-0514
J9 SHOCK
JI Shock
PD JUN
PY 2014
VL 41
SU 2
BP 94
EP 94
PG 1
WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease
SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System
& Cardiology
GA AI6ET
UT WOS:000336964600233
ER
PT J
AU Morrison, JJ
Stannard, A
Midwinter, MJ
Sharon, DJ
Eliason, JL
Rasmussen, TE
AF Morrison, Jonathan J.
Stannard, Adam
Midwinter, Mark J.
Sharon, Danny J.
Eliason, Jonathan L.
Rasmussen, Todd E.
TI Prospective evaluation of the correlation between torso height and
aortic anatomy in respect of a fluoroscopy free aortic balloon occlusion
system
SO SURGERY
LA English
DT Article
ID PENETRATING ABDOMINAL-TRAUMA; COMBAT CASUALTY CARE; HEMORRHAGIC-SHOCK;
RESUSCITATIVE THORACOTOMY; ANEURYSMS; IMPACT; DEATH; MODEL
AB Background. To report the lengths of key torso vascular and to develop regression models that will predict these lengths, based on an external measure of torso height (EMTH, sternum to pubis) in the development of a fluoroscopy-free balloon occlusion system for hemorrhage control.
Methods. We conducted a prospective, observational study at a Combat Support Hospital in Southern Afghanistan using adult male patients undergoing computed tomography (CT). EMTH was recorded using a tape measure and intra-arterial distance was derived from CT imaging. Regression models to predict distance from the common femoral artery (CFA) into the middle of aortic zone I (left subclavian artery to celiac trunk) and zone III (infrarenal aorta) were developed from a random 20% of the cohort and validated by the remaining 80%.
Results. Overall, 177 male patients were included with a median (interquartile range [IQR]) age Of 23 (8) years. The median (IQR) lengths of aortic zone I and III were 222 (24), 31 (9), and 92 (15) mm. The mid-zone distance from the left and right CFA to zone I were 423 (27) and 418 (29) and for zone III 232 (21) and 228 (22). Linear regression models demonstrated an accuracy between 99.3% to 100% at predicting the insertion distance required to place a catheter within the middle of each aortic zone.
Conclusion. This study demonstrates the use of morphometric analysis in the development of a fluoroscopy-free balloon occlusion system for torso hemorrhage control. Further study in a larger population of mixed gender is required to further validate insertion models.
C1 [Morrison, Jonathan J.; Stannard, Adam; Midwinter, Mark J.] Royal Ctr Def Med, Acad Dept Mil Surg & Trauma, Birmingham, W Midlands, England.
[Morrison, Jonathan J.; Rasmussen, Todd E.] US Army, Inst Surg Res, Ft Sam Houston, TX 78234 USA.
[Morrison, Jonathan J.] Glasgow Royal Infirm, Acad Surg Unit, Glasgow G4 0SF, Lanark, Scotland.
[Sharon, Danny J.] Joint Base San Antonio Lackland, Air Force Med Support Agency, Lackland AFB, TX 78236 USA.
[Eliason, Jonathan L.] Univ Michigan, Div Vasc Surg, Ann Arbor, MI 48109 USA.
[Rasmussen, Todd E.] Joint Base San Antonio Lackland, Med Wing 59th, Lackland AFB, TX USA.
[Rasmussen, Todd E.] Uniformed Serv Univ Hlth Sci, Norman M Rich Dept Surg, Bethesda, MD 20814 USA.
RP Rasmussen, TE (reprint author), Deputy Commander US Army, Inst Surg Res, Ft Sam Houston, TX 78234 USA.
EM todd.e.rasmussen.mil@mail.mil
RI Midwinter, Mark/P-6264-2015;
OI Midwinter, Mark/0000-0003-1836-7137; Morrison,
Jonathan/0000-0001-7462-8456
NR 20
TC 5
Z9 5
U1 0
U2 2
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0039-6060
J9 SURGERY
JI Surgery
PD JUN
PY 2014
VL 155
IS 6
BP 1044
EP 1051
DI 10.1016/j.surg.2013.12.036
PG 8
WC Surgery
SC Surgery
GA AI6RW
UT WOS:000337005700013
PM 24856124
ER
PT J
AU Watson, JDB
Aden, JK
Engel, JE
Rasmussen, TE
Glasgow, SC
AF Watson, J. Devin B.
Aden, James K.
Engel, Julie E.
Rasmussen, Todd E.
Glasgow, Sean C.
TI Risk factors for colostomy in military colorectal trauma: A review of
867 patients
SO SURGERY
LA English
DT Article; Proceedings Paper
CT 8th Annual Academic Surgical Congress
CY FEB 05-07, 2013
CL New Orleans, LA
SP Assoc Acad Surg, Soc Univ Surg
ID OPERATION IRAQI FREEDOM; DAMAGE CONTROL LAPAROTOMY; PRIMARY ANASTOMOSIS;
RECTAL INJURIES; CONTROL SURGERY; COLON INJURIES; MANAGEMENT; COMBAT;
CASUALTIES; OUTCOMES
AB Background. Limited data exist examining the use of fecal diversion in combatants from modern armed conflicts. Characterization of factors leading to colostomy creation is an initial step toward optimizing and individualizing combat casualty care.
Methods. A retrospective review of the US Department of Defense Trauma Registry database was performed for all US and coalition troops with colorectal injuries sustained during combat operations in Iraq and Afghanistan over 8 years. Colostomy rate, anatomic injury location, mechanism of injury, demographic data, and initial physiologic parameters were examined. Univariate and multivariate analyses were conducted.
Results. We identified 867 coalition military personnel with colorectal injuries. The overall colostomy rate was 37%. Rectal injuries had the highest diversion rate (56%), followed by left-sided (41%) and right-sided (20%) locations (P < .0001). Those with gunshot wounds (GSW) underwent diversion more often than blast injuries (43% vs 31% respectively, P < .0008). Injury Severity Score >= 16 (41% vs 30%; P = .0018) and damage control surgery (DCS; 48.2% vs 31.4%; P < .0001) were associated with higher diversion rates. On multivariate analysis, significant predictors for colostomy creation were injury location: Rectal versus left colon (odds ratio [OR], 2.2), rectal versus right colon (OR, 7.5), left versus right colon (OR, 3.4), GSW (OR, 2.0), ISS >= 16 (OR, 1.7), and DCS (OR, 1.6).
Conclusion. In this exploratory study of 320 combat-related colostomies, distal colon and rectal injuries continue to be diverted at higher rates independent of other comorbidities. Additional outcomes-directed research is needed to determine whether such operative management is beneficial in all patients.
C1 [Watson, J. Devin B.; Glasgow, Sean C.] San Antonio Mil Med Ctr, Dept Surg, Ft Sam Houston, TX USA.
[Watson, J. Devin B.; Aden, James K.; Engel, Julie E.; Rasmussen, Todd E.] US Army, Inst Surg Res, Ft Sam Houston, TX 78234 USA.
[Rasmussen, Todd E.] Uniformed Serv Univ Hlth Sci, Norman M Rich Dept Surg, Bethesda, MD 20814 USA.
[Glasgow, Sean C.] St Louis Univ, Dept Surg, St Louis, MO 63103 USA.
RP Glasgow, SC (reprint author), 3635 Vista Ave Grand Blvd,3rd Floor,Desloge Tower, St Louis, MO 63110 USA.
EM glasgowsc@slu.edu
NR 27
TC 4
Z9 4
U1 0
U2 2
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0039-6060
J9 SURGERY
JI Surgery
PD JUN
PY 2014
VL 155
IS 6
BP 1052
EP 1061
DI 10.1016/j.surg.2014.01.010
PG 10
WC Surgery
SC Surgery
GA AI6RW
UT WOS:000337005700014
PM 24856125
ER
PT J
AU Morgan, TR
AF Morgan, Theodore R.
TI Evaluation of Fluid Bolus Administration Rates Using Ruggedized Field
Intravenous Systems
SO WILDERNESS & ENVIRONMENTAL MEDICINE
LA English
DT Article
DE ruggedized field IV; Ranger IV; saline lock; tactical combat casualty
care (TCCC); fluid resuscitation; pressure infusion
AB Objective.-The purpose of this study was to evaluate 2 ruggedized field intravenous (IV) systems currently in use by US military medics and to determine their effect on fluid bolus administration rates.
Methods.-A series of 500 mL fluid boluses consisting of either Lactated Ringer's solution or Hextend were delivered to 2 artificial intravenous training arms using a standard 18G catheter (control) and 2 separate ruggedized field IV systems. Fluid boluses were delivered under both gravity force and pressure infusion (constant 300 mm Hg), and total bolus times were recorded.
Results.-Using Lactated Ringer's solution, the standard IV system took a mean time of 9:33 minutes (95% CI: 9:13-9:54) to deliver a 500 mL fluid bolus whereas the 2 ruggedized field systems took mean times of 14:50 minutes (95% CI: 14:00-15:40) and 12:20 minutes (95% CI: 11:54-12:45). Using Hextend, the mean bolus time for the control system was 24:39 minutes (95% CI: 22:47-26:32). The 2 ruggedized field systems required an average of 49:32 minutes (95% CI: 48:07-50:58) and 39:46 minutes (95% CI: 37:30-42:01) to deliver an equivalent bolus. Pressure infusion significantly increased flow rate in all systems.
Conclusions.-Ruggedized field IV systems can significantly delay fluid bolus rates. In instances where ruggedized field systems are deemed necessary, pressure infusion devices should be considered to overcome the constrictive effects of the ruggedized system.
C1 [Morgan, Theodore R.] US Army Special Warfare Med Grp Airborne, Ft Bragg, NC USA.
RP Morgan, TR (reprint author), 36 Myst Lane, Lillington, NC 27546 USA.
EM theodore.ross.morgan@gmail.com
NR 10
TC 0
Z9 0
U1 0
U2 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1080-6032
EI 1545-1534
J9 WILD ENVIRON MED
JI Wildern. Environ. Med.
PD SUM
PY 2014
VL 25
IS 2
BP 204
EP 209
PG 6
WC Public, Environmental & Occupational Health; Sport Sciences
SC Public, Environmental & Occupational Health; Sport Sciences
GA AI5YL
UT WOS:000336946800012
PM 24631229
ER
PT J
AU Sontgerath, JS
Rubal, BJ
DeLorenzo, RA
Morgan, TL
Ward, JA
AF Sontgerath, Joseph S.
Rubal, Bernard J.
DeLorenzo, Robert A.
Morgan, Trent L.
Ward, John A.
TI Variability in intraosseous flush practices of emergency physicians
SO AMERICAN JOURNAL OF EMERGENCY MEDICINE
LA English
DT Article
ID BONE-MARROW; INFUSION RATES; FAT-EMBOLISM; CLINICAL RELEVANCE; VASCULAR
ACCESS; SWINE MODEL; PRESSURE; BLOOD; ECHOCARDIOGRAPHY; SAFETY
AB IncObjective: Intramedullary pressure changes during intraosseous (IO) procedures have been implicated in the intravasation of bone marrow fat and with pain in conscious patients. The objective of this study was to demonstrate inter-provider variability in pressures generated during initial flush procedures.
Methods: IO cannulas were inserted into the proximal tibiae and humeri by study personnel. A second cannula was placed in the mid diaphysis of each bone to record intramedullary pressures. Fifteen emergency physicians performed 60 flushes in random order in two cadavers while flush duration and IO pressure were continuously recorded. Providers were blinded to the flush pressures they generated and the flush techniques of others.
Results: The median IO pressure (IOP) generated by providers was 903 mm Hg (range, 83-2941 mm Hg) and the median flush duration was 5.2 seconds (range, 1.0-13.4 seconds). Significant differences were noted among providers in peak IOP generated (analysis of variance P<.001). Providers were consistent in the forces they generated relative to each other. An inverse, nonlinear relationship was observed between flush duration and the peak IOP generated. Significant differences were noted in intramedullary flush pressures at flush sites within cadavers (analysis of variance P: cadaver #1 P<.001; cadaver #2 P=.012).
Conclusions: The IO compartment pressures generated by physicians demonstrated significant interoperator variability with greater than 35-fold difference in flush forces, and an inverse relationship between intraosseous pressure and flush duration. It may be prudent practice for providers to extend the flush over several seconds, thus limiting maximal pressures. Published by Elsevier Inc.
C1 [Sontgerath, Joseph S.; Morgan, Trent L.] Dept Emergency Med, Ft Sam Houston, TX 78234 USA.
[Rubal, Bernard J.; Ward, John A.] San Antonio Mil Med Ctr, Serv Cardiol, Ft Sam Houston, TX 78234 USA.
[DeLorenzo, Robert A.] US Army, Inst Surg Res, Ft Sam Houston, TX 78234 USA.
RP Sontgerath, JS (reprint author), Mike OCallaghan Fed Med Ctr, Dept Emergency Med, 4700 N Las Vegas Blvd, Nellis Afb, NV 89191 USA.
EM joseph.sontgerath.1@us.af.mil
FU US Army Tele-medicine and Advanced Technology Research Center
FX Funding was provided by the US Army Tele-medicine and Advanced
Technology Research Center.
NR 36
TC 2
Z9 2
U1 0
U2 2
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0735-6757
EI 1532-8171
J9 AM J EMERG MED
JI Am. J. Emerg. Med.
PD JUN
PY 2014
VL 32
IS 6
BP 665
EP 669
DI 10.1016/j.ajem.2014.03.001
PG 5
WC Emergency Medicine
SC Emergency Medicine
GA AI1AK
UT WOS:000336581800035
PM 24725773
ER
PT J
AU Lewis, CL
Craig, CC
Senecal, AG
AF Lewis, Christina L.
Craig, Caelli C.
Senecal, Andre G.
TI Mass and Density Measurements of Live and Dead Gram-Negative and
Gram-Positive Bacterial Populations
SO APPLIED AND ENVIRONMENTAL MICROBIOLOGY
LA English
DT Article
ID LISTERIA-MONOCYTOGENES; ESCHERICHIA-COLI; INDIVIDUAL CELLS;
IMAGE-ANALYSIS; SINGLE CELLS; GROWTH; DISTRIBUTIONS; TIMES; MICROSCOPY;
DIVISION
AB Monitoring cell growth and measuring physical features of food-borne pathogenic bacteria are important for better understanding the conditions under which these organisms survive and proliferate. To address this challenge, buoyant masses of live and dead Escherichia coli O157:H7 and Listeria innocua were measured using Archimedes, a commercially available suspended microchannel resonator (SMR). Cell growth was monitored with Archimedes by observing increased cell concentration and buoyant mass values of live growing bacteria. These growth data were compared to optical density measurements obtained with a Bioscreen system. We observed buoyant mass measurements with Archimedes at cell concentrations between 10(5) and 10(8) cells/ml, while growth was not observed with optical density measurements until the concentration was 10(7) cells/ml. Buoyant mass measurements of live and dead cells with and without exposure to hydrogen peroxide stress were also compared; live cells generally had a larger buoyant mass than dead cells. Additionally, buoyant mass measurements were used to determine cell density and total mass for both live and dead cells. Dead E. coli cells were found to have a larger density and smaller total mass than live E. coli cells. In contrast, density was the same for both live and dead L. innocua cells, while the total mass was greater for live than for dead cells. These results contribute to the ongoing challenge to further develop existing technologies used to observe cell populations at low concentrations and to measure unique physical features of cells that may be useful for developing future diagnostics.
C1 [Lewis, Christina L.; Craig, Caelli C.; Senecal, Andre G.] US Army Natick Soldier Res, Food Protect Team, Combat Feeding Directorate, Ctr Dev & Engn, Natick, MA 01760 USA.
RP Lewis, CL (reprint author), US Army Natick Soldier Res, Food Protect Team, Combat Feeding Directorate, Ctr Dev & Engn, Natick, MA 01760 USA.
EM christina.l.lewis23.ctr@mail.mil
FU National Research Council
FX This research was performed while author Christina L. Lewis held a
National Research Council Research Associateship Award at Natick Soldier
Research, Development, and Engineering Center.
NR 26
TC 4
Z9 4
U1 5
U2 22
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0099-2240
EI 1098-5336
J9 APPL ENVIRON MICROB
JI Appl. Environ. Microbiol.
PD JUN
PY 2014
VL 80
IS 12
BP 3622
EP 3631
DI 10.1128/AEM.00117-14
PG 10
WC Biotechnology & Applied Microbiology; Microbiology
SC Biotechnology & Applied Microbiology; Microbiology
GA AI3EX
UT WOS:000336744000009
PM 24705320
ER
PT J
AU Fowler, M
Clifford, JL
Garza, TH
Slater, TM
Arizpe, HM
Novak, J
Petz, LN
Loyd, DR
AF Fowler, Marcie
Clifford, John L.
Garza, Thomas H.
Slater, Terry M.
Arizpe, Helen M.
Novak, Joseph
Petz, Lawrence N.
Loyd, Dayna R.
TI A rat model of full thickness thermal injury characterized by thermal
hyperalgesia, mechanical allodynia, pronociceptive peptide release and
tramadol analgesia
SO BURNS
LA English
DT Article
DE Pain; Burn; Opioid analgesia; CGRP; Substance P
ID GENE-RELATED PEPTIDE; HINDPAW BURN INJURY; SECONDARY HYPERALGESIA;
NEUROPATHIC PAIN; PERIAQUEDUCTAL GRAY; SUBSTANCE-P; SOMATOTOPIC
ORGANIZATION; RECEPTOR ANTAGONIST; POSTOPERATIVE PAIN; MORPHINE
ANALGESIA
AB Opioid-related side effects are problematic for burn patients. Dual mechanism therapeutics targeting opioid and non-opioid mechanisms may have reduced side effects with similar analgesic efficacy. Tramadol combines mu opioid receptor agonism with norepinephrine reuptake inhibition and has been effective in treating some types of pain. The effectiveness of tramadol in treating pain associated with burns is unclear. We hypothesized that tramadol is effective in reducing thermal injury-evoked pain behaviors in a rat model. Rats were anesthetized and a 100 degrees C metal probe was placed on the hindpaw for 30 s to induce a full thickness thermal injury. A subset of rats was perfusion fixed and hindpaw tissue and spinal cord collected for anatomical analysis. Rats received morphine (5 mg/kg; i.p.), tramadol (10-30 mg/kg; i.p.) or vehicle and latency to paw withdrawal from a noxious thermal or non-noxious mechanical stimulus was recorded every 10 min over 70 min and again at 2 h. We report that pain behaviors developed within 48 h and peaked at 1 week; paralleled by enhanced expression of pronociceptive neuropeptides in the spinal cord. Morphine and tramadol significantly attenuated hyperalgesia and allodynia, while not significantly altering motor coordination/sedation. These data indicate dual mechanism therapeutics may be effective for treating pain associated with burns. Published by Elsevier Ltd and ISBI
C1 [Fowler, Marcie; Clifford, John L.; Garza, Thomas H.; Slater, Terry M.; Arizpe, Helen M.; Petz, Lawrence N.; Loyd, Dayna R.] US Army Inst Surg Res, Pain Management Res Area, JBSA, Ft Sam Houston, TX 78234 USA.
[Novak, Joseph] US Army Inst Surg Res, JBSA, Ft Sam Houston, TX 78234 USA.
RP Loyd, DR (reprint author), US Army Inst Surg Res, Pain Management Res Area, JBSA, 3698 Chambers Pass, Ft Sam Houston, TX 78234 USA.
EM dayna.l.averitt.civ@mail.mil
OI Averitt, Dayna/0000-0001-8345-4988; Loyd, Dayna/0000-0002-5635-185X
FU United States Army Medical Research and Materiel Command Combat Casualty
Care Research; Clinical and Rehabilitative Medicine Research programs
FX The authors would like to acknowledge the technical assistance of Zach
Silvias, Angie Greer and Alberto Mares. We thank Drs. Kenneth M.
Hargreaves and Laura McGhee for helpful comments on study design. This
work was supported by the United States Army Medical Research and
Materiel Command Combat Casualty Care Research and the Clinical and
Rehabilitative Medicine Research programs.
NR 53
TC 8
Z9 8
U1 0
U2 4
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0305-4179
EI 1879-1409
J9 BURNS
JI Burns
PD JUN
PY 2014
VL 40
IS 4
BP 759
EP 771
DI 10.1016/j.burns.2013.10.011
PG 13
WC Critical Care Medicine; Dermatology; Surgery
SC General & Internal Medicine; Dermatology; Surgery
GA AI2QN
UT WOS:000336703200031
PM 24290856
ER
PT J
AU Williams, KS
Andzelm, JW
Dong, H
Snyder, JF
AF Williams, Kristen S.
Andzelm, Jan W.
Dong, Hong
Snyder, James F.
TI DFT study of metal cation-induced hydrogelation of cellulose nanofibrils
SO CELLULOSE
LA English
DT Article
DE Cellulose nanofibrils; Hydrogels; Carboxylate; Molecular modeling;
Density functional theory; Implicit solvation model
ID DENSITY-FUNCTIONAL CALCULATIONS; GEOMETRY OPTIMIZATION; I-BETA; SURFACES
AB We report a density functional theory study of cation-induced bonding between carboxylated cellulose nanofibrils (CNFs). We describe a methodology of using cleaved cellulose crystal unit cells to develop simple surface and molecular models of charged CNFs. We compare bond lengths, binding energies, and displaced solvation volumes for interfibril models intercalated with alkali, alkaline earth, main group, or transition metal cations, surrounded by an implicit solvent. We characterize the type of bonding interactions that occur between metal cations, Mn+ and carboxylated CNF surfaces by calculating the electronic density of states and Mayer bond orders. We find that Mn+-O interactions for alkaline earth metal systems are predominantly electrostatic whereas transition metal cations form stronger, more covalent bonds with enhanced valence orbital overlap. Our results show that multivalent-as opposed to monovalent-ions can create CNF networks by effectively crosslinking multiple fibrils through surface carboxylate anions. Our computational results agree with empirical models of metal-carboxylate binding, while also providing a deeper understanding of the bonding mechanisms for different cations. Our findings help to explain trends in recent CNF hydrogelation experiments, and we also predict the existence of two new hydrogels-CNF-Mg2+ and CNF-Zr4+.
C1 [Williams, Kristen S.; Andzelm, Jan W.; Dong, Hong; Snyder, James F.] US Army Res Lab, Macromol Sci & Technol Branch, Aberdeen Proving Ground, MD 21005 USA.
[Dong, Hong] Bowhead Sci & Technol LLC, Belcamp, MD 21017 USA.
RP Williams, KS (reprint author), US Army Res Lab, Macromol Sci & Technol Branch, 4600 Deer Creek Loop, Aberdeen Proving Ground, MD 21005 USA.
EM kristen.s.williams7.ctr@mail.mil
NR 30
TC 2
Z9 2
U1 6
U2 34
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0969-0239
EI 1572-882X
J9 CELLULOSE
JI Cellulose
PD JUN
PY 2014
VL 21
IS 3
BP 1091
EP 1101
DI 10.1007/s10570-014-0254-y
PG 11
WC Materials Science, Paper & Wood; Materials Science, Textiles; Polymer
Science
SC Materials Science; Polymer Science
GA AH7OL
UT WOS:000336322800002
ER
PT J
AU Conner, JC
Olsen, MJ
AF Conner, Jeremy C.
Olsen, Michael J.
TI Automated quantification of distributed landslide movement using
circular tree trunks extracted from terrestrial laser scan data
SO COMPUTERS & GEOSCIENCES
LA English
DT Article
DE Laser scanning; LIDAR; Landslide; Coastal; Erosion; Topography;
Deformation modeling
ID EROSION; CALIFORNIA
AB This manuscript presents a novel algorithm to automatically detect landslide movement in a forested area using displacements of tree trunks distributed across the landslide surveyed repeatedly using terrestrial laser scanning (TLS). Common landslide monitoring techniques include: inclinometers, global position system (GPS), and interferometric synthetic aperture radar (InSAR). While these techniques provide valuable data for monitoring landslides, they can be difficult to apply with adequate spatial or temporal resolution needed to understand complex landslides, specifically in forested environments. Comparison of the center coordinates (determined via least-squares fit of the TLS data) of a cross section of the tree trunk between consecutive surveys enable quantification of landslide movement rates, which can be used to analyze patterns of landslide displacement The capabilities of this new methodology were tested through a case-study analyzing the Johnson Creek Landslide, a complex, quick moving coastal landslide, which has proven difficult to monitor using other techniques. A parametric analysis of fitting thresholds was also conducted to determine the reliability of tree trunk displacements calculated and the number of features that were extracted. The optimal parameters in selecting trees for movement analysis were found to be less than 1.5 cm for the RMS residuals of the circle fit and less than 1.0 cm for the difference in the calculated tree radii between epochs. (C) 2014 Elsevier Ltd. All rights reserved.
C1 [Conner, Jeremy C.] US Mil Acad, Dept Geog & Environm Engn, West Point, NY 10966 USA.
[Olsen, Michael J.] Oregon State Univ, Sch Civil & Construct Engn, Corvallis, OR 97331 USA.
RP Olsen, MJ (reprint author), Oregon State Univ, Sch Civil & Construct Engn, 220 Owen Hall, Corvallis, OR 97331 USA.
EM jeremy.conner1@us.army.mil; michael.olsen@oregonstate.edu
FU United States Army; Oregon Department of Transportation [SPR 740]
FX The authors would like to thank Leica Geosystems, David Evans &
Associates, and Maptek I-Site for providing the equipment and software
used for this research. Additionally, the United States Army, Eric HI
and Janice Hoffman and Oregon Department of Transportation (SPR 740)
provided funding for this study. Thank you to Jonathan Allan and George
Priest for a thorough Johnson Creek Landslide site visit physically
showing and explaining previous work done and the geological setting.
Thank you to Keith Williams, Rubini Mahalingam, and John Raugust for
assistance with data collection.
NR 30
TC 3
Z9 3
U1 4
U2 27
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0098-3004
EI 1873-7803
J9 COMPUT GEOSCI-UK
JI Comput. Geosci.
PD JUN
PY 2014
VL 67
BP 31
EP 39
DI 10.1016/j.cageo.2014.02.007
PG 9
WC Computer Science, Interdisciplinary Applications; Geosciences,
Multidisciplinary
SC Computer Science; Geology
GA AI3QZ
UT WOS:000336778300004
ER
PT J
AU Stewart, IJ
Sosnov, JA
Chung, KK
AF Stewart, Ian J.
Sosnov, Jonathan A.
Chung, Kevin K.
TI Vasopressin, Sepsis, and Renal Perfusion-A VASST Deficit in Our
Understanding
SO CRITICAL CARE MEDICINE
LA English
DT Editorial Material
DE acute kidney injury; renal blood flow; sepsis; shock; vasopressin
ID ACUTE KIDNEY INJURY; SEVERE SEPTIC SHOCK; ARGININE-VASOPRESSIN;
NOREPINEPHRINE; INFUSION
C1 [Stewart, Ian J.; Sosnov, Jonathan A.] San Antonio Mil Med Ctr, Dept Med, Ft Sam Houston, TX 78234 USA.
[Chung, Kevin K.] US Army Inst Surg Res, Ft Sam Houston, TX USA.
[Chung, Kevin K.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA.
RP Stewart, IJ (reprint author), San Antonio Mil Med Ctr, Dept Med, Ft Sam Houston, TX 78234 USA.
NR 15
TC 1
Z9 1
U1 1
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0090-3493
EI 1530-0293
J9 CRIT CARE MED
JI Crit. Care Med.
PD JUN
PY 2014
VL 42
IS 6
BP 1583
EP 1584
DI 10.1097/CCM.0000000000000354
PG 2
WC Critical Care Medicine
SC General & Internal Medicine
GA AH6UM
UT WOS:000336266900069
PM 24836811
ER
PT J
AU Snider, TH
Perry, MR
Richter, WR
Plahovinsak, JL
Rogers, J
Reid, FM
Graham, JS
AF Snider, Thomas H.
Perry, Mark R.
Richter, William R.
Plahovinsak, Jennifer L.
Rogers, James
Reid, Frances M.
Graham, John S.
TI A dynamic system for delivering controlled bromine and chlorine vapor
exposures to weanling swine skin
SO CUTANEOUS AND OCULAR TOXICOLOGY
LA English
DT Article
DE Bromine; chlorine; cutaneous; dermal; halogen; injury; model; vapor
ID SULFUR MUSTARD; CHEMICAL BURNS; MODEL; PIG
AB Context: Assessing the hazards of accidental exposure to toxic industrial chemical (TIC) vapors and evaluating therapeutic compounds or treatment regimens require the development of appropriate animal models.
Objective: The objective of this project was to develop an exposure system for delivering controlled vapor concentrations of TICs to the skin of anesthetized weanling pigs. Injury levels targeted for study were superficial dermal (SD) and deep dermal (DD) skin lesions as defined histopathologically.
Materials and methods: The exposure system was capable of simultaneously delivering chlorine or bromine vapor to four, 3-cm diameter exposure cups placed over skin between the axillary and inguinal areas of the ventral abdomen. Vapor concentrations were generated by mixing saturated bromine or chlorine vapor with either dried dilution air or nitrogen.
Results: Bromine exposure concentrations ranged from 6.5 x 10(-4) to 1.03 g/L, and exposure durations ranged from 1 to 45 min. A 7-min skin exposure to bromine vapors at 0.59 g/L was sufficient to produce SD injuries, while a 17-min exposure produced a DD injury. Chlorine exposure concentrations ranged from 1.0 to 2.9 g/L (saturated vapor concentration) for exposures ranging from 3 to 90 min. Saturated chlorine vapor challenges for up to 30 min did not induce significant dermal injuries, whereas saturated chlorine vapor with wetted material on the skin surface for 30-60 min induced SD injuries. DD chlorine injuries could not be induced with this system.
Conclusion: The vapor exposure system described in this study provides a means for safely regulating, quantifying and delivering TIC vapors to the skin of weanling swine as a model to evaluate therapeutic treatments.
C1 [Snider, Thomas H.; Perry, Mark R.; Richter, William R.; Plahovinsak, Jennifer L.; Rogers, James; Reid, Frances M.] Battelle Mem Inst, Biomed Res Ctr, Columbus, OH 43201 USA.
[Graham, John S.] US Army, Med Res Inst Chem Def, Aberdeen, MD USA.
RP Snider, TH (reprint author), Battelle Mem Inst, Biomed Res Ctr, 505 King Ave, Columbus, OH 43201 USA.
EM snidert@battelle.org
FU US Army Medical Research and Materiel Command [W81XWH-05-D-0001]; US
Army Medical Research Institute of Chemical Defense (USAMRICD); National
Institutes of Health, National Institute of Allergies and Infectious
Disease (NIAID), IAA [Y1-AI-6177-02]
FX The authors have no known conflicts of interest. This work was supported
by the US Army Medical Research and Materiel Command under Contract
W81XWH-05-D-0001, Task Order 0010 with funding support through an
Interagency Agreement (IAA) between the US Army Medical Research
Institute of Chemical Defense (USAMRICD) and National Institutes of
Health, National Institute of Allergies and Infectious Disease (NIAID),
IAA Number Y1-AI-6177-02.
NR 24
TC 3
Z9 3
U1 0
U2 1
PU INFORMA HEALTHCARE
PI LONDON
PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND
SN 1556-9527
EI 1556-9535
J9 CUTAN OCUL TOXICOL
JI Cutan. Ocul. Toxicol.
PD JUN
PY 2014
VL 33
IS 2
BP 161
EP 167
DI 10.3109/15569527.2013.806524
PG 7
WC Ophthalmology; Toxicology
SC Ophthalmology; Toxicology
GA AI3AV
UT WOS:000336731700016
PM 23808400
ER
PT J
AU Russell, DW
Russell, CA
Riviere, LA
Thomas, JL
Wilk, JE
Bliese, PD
AF Russell, Dale W.
Russell, Cristel Antonia
Riviere, Lyndon A.
Thomas, Jeffrey L.
Wilk, Joshua E.
Bliese, Paul D.
TI Changes in alcohol use after traumatic experiences: The impact of combat
on Army National Guardsmen
SO DRUG AND ALCOHOL DEPENDENCE
LA English
DT Article
DE Alcohol; Longitudinal; Military; National Guard
ID POSTTRAUMATIC-STRESS-DISORDER; MENTAL-HEALTH PROBLEMS; MORTALITY
SALIENCE; DRINKING MOTIVES; SELF-ESTEEM; SOLDIERS; DEPLOYMENT; MILITARY;
GROWTH; IRAQ
AB Objective: This research documents the impact of combat experiences on alcohol use and misuse among National Guard soldiers. Whereas much research regarding combat personnel is based on post-experience data, this study's design uses both pre- and post-deployment data to identify the association between different types of combat experiences and changes in substance use and misuse.
Method: A National Guard Infantry Brigade Combat Team was surveyed before and after its deployment to Iraq in 2005-2006. Members of the unit completed anonymous surveys regarding behavioral health and alcohol use and, in the post-survey, the combat experiences they had during deployment. The unit was surveyed 3 months prior to its deployment and 3 months after its deployment.
Results: Prevalence rates of alcohol use increased from 70.8% pre-deployment to 80.5% post-deployment. Prevalence rates of alcohol misuse more than doubled, increasing from 8.51% before deployment to 19.15% after deployment. However, among the combat experiences examined in this study, changes in alcohol misuse post-deployment appear to be solely affected by the combat experience of killing. Alcohol misuse decreased amongst those who experienced killing during combat.
Conclusions: This study highlights the role of combat experiences on substance use. Published by Elsevier Ireland Ltd.
C1 [Russell, Dale W.; Riviere, Lyndon A.; Thomas, Jeffrey L.; Wilk, Joshua E.; Bliese, Paul D.] Walter Reed Army Inst Res, Silver Spring, MD 20910 USA.
[Russell, Cristel Antonia] Amer Univ, Washington, DC 20016 USA.
[Russell, Dale W.] Uniformed Serv Univ Hlth Sci, F Edward Hebert Sch Med, Dept Psychiat, Bethesda, MD 20814 USA.
RP Russell, DW (reprint author), Walter Reed Army Inst Res, 503 Robert Grant Ave, Silver Spring, MD 20910 USA.
EM dale.w.russell1.mil@mail.mil
OI RUSSELL, CRISTEL/0000-0002-1918-6381
FU Military Operational Medicine Research Area Directorate, U.S. Army
Medical Research and Materiel Command, Ft. Detrick, MD
FX Funding for this project came from the Military Operational Medicine
Research Area Directorate, U.S. Army Medical Research and Materiel
Command, Ft. Detrick, MD.
NR 57
TC 1
Z9 1
U1 1
U2 16
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
IRELAND
SN 0376-8716
EI 1879-0046
J9 DRUG ALCOHOL DEPEN
JI Drug Alcohol Depend.
PD JUN 1
PY 2014
VL 139
BP 47
EP 52
DI 10.1016/j.drugalcdep.2014.03.004
PG 6
WC Substance Abuse; Psychiatry
SC Substance Abuse; Psychiatry
GA AI2SI
UT WOS:000336708000007
PM 24685562
ER
PT J
AU Tschopp, MA
Murdoch, HA
Kecskes, LJ
Darling, KA
AF Tschopp, M. A.
Murdoch, H. A.
Kecskes, L. J.
Darling, K. A.
TI "Bulk" Nanocrystalline Metals: Review of the Current State of the Art
and Future Opportunities for Copper and Copper Alloys
SO JOM
LA English
DT Article
ID TILT GRAIN-BOUNDARIES; SEVERE PLASTIC-DEFORMATION; CENTERED-CUBIC
METALS; CHANNEL ANGULAR EXTRUSION; STRAIN-RATE SENSITIVITY; SCANNING
THERMAL MICROSCOPY; MECHANICAL ATTRITION TREATMENT; MOLECULAR-DYNAMICS
SIMULATION; COHERENT TWIN BOUNDARIES; STACKING-FAULT ENERGIES
AB It is a new beginning for innovative fundamental and applied science in nanocrystalline materials. Many of the processing and consolidation challenges that have haunted nanocrystalline materials are now more fully understood, opening the doors for bulk nanocrystalline materials and parts to be produced. While challenges remain, recent advances in experimental, computational, and theoretical capability have allowed for bulk specimens that have heretofore been pursued only on a limited basis. This article discusses the methodology for synthesis and consolidation of bulk nanocrystalline materials using mechanical alloying, the alloy development and synthesis process for stabilizing these materials at elevated temperatures, and the physical and mechanical properties of nanocrystalline materials with a focus throughout on nanocrystalline copper and a nanocrystalline Cu-Ta system, consolidated via equal channel angular extrusion, with properties rivaling that of nanocrystalline pure Ta. Moreover, modeling and simulation approaches as well as experimental results for grain growth, grain boundary processes, and deformation mechanisms in nanocrystalline copper are briefly reviewed and discussed. Integrating experiments and computational materials science for synthesizing bulk nanocrystalline materials can bring about the next generation of ultrahigh strength materials for defense and energy applications.
C1 [Tschopp, M. A.; Murdoch, H. A.; Kecskes, L. J.; Darling, K. A.] US Army Res Lab, Aberdeen, MD 21005 USA.
RP Tschopp, MA (reprint author), US Army Res Lab, Aberdeen, MD 21005 USA.
EM mark.tschopp@gatech.edu
OI Tschopp, Mark/0000-0001-8471-5035
NR 205
TC 19
Z9 19
U1 9
U2 84
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1047-4838
EI 1543-1851
J9 JOM-US
JI JOM
PD JUN
PY 2014
VL 66
IS 6
BP 1000
EP 1019
DI 10.1007/s11837-014-0978-z
PG 20
WC Materials Science, Multidisciplinary; Metallurgy & Metallurgical
Engineering; Mineralogy; Mining & Mineral Processing
SC Materials Science; Metallurgy & Metallurgical Engineering; Mineralogy;
Mining & Mineral Processing
GA AI2ZM
UT WOS:000336727700021
ER
PT J
AU Grujicic, M
Yavari, R
Snipes, JS
Ramaswami, S
Yen, CF
Cheeseman, BA
AF Grujicic, M.
Yavari, R.
Snipes, J. S.
Ramaswami, S.
Yen, C-F
Cheeseman, B. A.
TI Linear Friction Welding Process Model for Carpenter Custom 465
Precipitation-Hardened Martensitic Stainless Steel
SO JOURNAL OF MATERIALS ENGINEERING AND PERFORMANCE
LA English
DT Article
DE Carpenter Custom 465 precipitation-hardened martensitic stainless steel;
linear friction welding; process modeling
ID MECHANICAL-PROPERTIES; WELDED 45-STEEL; MICROSTRUCTURE; TI-6AL-4V;
AUSTENITE; ALLOY
AB An Arbitrary Lagrangian-Eulerian finite-element analysis is combined with thermo-mechanical material constitutive models for Carpenter Custom 465 precipitation-hardened martensitic stainless steel to develop a linear friction welding (LFW) process model for this material. The main effort was directed toward developing reliable material constitutive models for Carpenter Custom 465 and toward improving functional relations and parameterization of the workpiece/workpiece contact-interaction models. The LFW process model is then used to predict thermo-mechanical response of Carpenter Custom 465 during LFW. Specifically, temporal evolutions and spatial distribution of temperature within, and expulsion of the workpiece material from, the weld region are examined as a function of the basic LFW process parameters, i.e., (a) contact-pressure history, (b) reciprocation frequency, and (c) reciprocation amplitude. Examination of the results obtained clearly revealed the presence of three zones within the weld, i.e., (a) Contact-interface region, (b) Thermo-mechanically affected zone, and (c) heat-affected zone. While there are no publicly available reports related to Carpenter Custom 465 LFW behavior, to allow an experiment/computation comparison, these findings are consistent with the results of our ongoing companion experimental investigation.
C1 [Grujicic, M.; Yavari, R.; Snipes, J. S.; Ramaswami, S.] Clemson Univ, Dept Mech Engn, Clemson, SC 29634 USA.
[Yen, C-F; Cheeseman, B. A.] Army Res Lab, Survivabil Mat Branch, Proving Ground, MD 21005 USA.
RP Grujicic, M (reprint author), Clemson Univ, Dept Mech Engn, 241 Engn Innovat Bldg, Clemson, SC 29634 USA.
EM gmica@clemson.edu
FU Army Research Office (ARO) [W911NF-11-1-0207]
FX The initial portion of the work presented in the current manuscript was
supported by the Army Research Office (ARO) through the grant
W911NF-11-1-0207. The authors are indebted to Dr. Ralph A. Anthenien,
Jr. of ARO for his continuing support and interest in the present work.
The authors would also like to thank Dr. David Bowden for helpful
discussions and encouragement.
NR 38
TC 8
Z9 8
U1 0
U2 16
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1059-9495
EI 1544-1024
J9 J MATER ENG PERFORM
JI J. Mater. Eng. Perform.
PD JUN
PY 2014
VL 23
IS 6
BP 2182
EP 2198
DI 10.1007/s11665-014-0985-9
PG 17
WC Materials Science, Multidisciplinary
SC Materials Science
GA AH8MZ
UT WOS:000336393300031
ER
PT J
AU Gaffney-Stomberg, E
Cao, JJ
Lin, GG
Wulff, CR
Murphy, NE
Young, AJ
McClung, JP
Pasiakos, SM
AF Gaffney-Stomberg, Erin
Cao, Jay J.
Lin, Gregory G.
Wulff, Charles R.
Murphy, Nancy E.
Young, Andrew J.
McClung, James P.
Pasiakos, Stefan M.
TI Dietary Protein Level and Source Differentially Affect Bone Metabolism,
Strength, and Intestinal Calcium Transporter Expression during Ad
Libitum and Food-Restricted Conditions in Male Rats
SO JOURNAL OF NUTRITION
LA English
DT Article
ID RANDOMIZED CONTROLLED-TRIAL; WEIGHT-LOSS; POSTMENOPAUSAL WOMEN;
PARATHYROID-HORMONE; YOUNG-WOMEN; FEMALE RATS; ENERGY; MASS;
SUPPLEMENTATION; REDUCTION
AB High-protein (HP) diets may attenuate bone loss during energy restriction. The objective of the current study was to determine whether HP diets suppress bone turnover and improve bone quality in male rats during food restriction and whether dietary protein source affects this relation. Eighty 12-wk-old male Sprague Dawley rats were randomly assigned to consume 1 of 4 study diets under ad libitum (AL) control or restricted conditions [40% food restriction (FR)]: 1) 10% [normal-protein (NP)] milk protein; 2 32% (HP) milk protein; 10% (NP) soy protein; or 4) 32% (HP) soy protein. After 16 wk, markers of bone turnover, volumetric bone mineral density (vBMD), microarchitecture, strength, and expression of duodenal calcium channels were assessed. FR increased bone turnover and resulted in lower femoral trabecular bone volume (P < 0.05), higher cortical bone surface (P < 0.001), and reduced femur length (P < 0.01), bending moment (P < 0.05), and moment of inertia (P = 0.001) compared with AL. HP intake reduced bone turnover and tended to suppress parathyroid hormone (PTH) (P = 0.06) and increase trabecular vBMD (P < 0.05) compared with NP but did not affect bone strength. Compared with milk, soy suppressed PTH (P < 0.05) and increased cortical vBMD (P < 0.05) and calcium content of the femur (P < 0.01) but did not affect strength variables. During AL conditions, transient receptor potential cation channel, subfamily V, member 6 was higher for soy than milk (P < 0.05) and HP compared with NP (P < 0.05). These data demonstrate that both HP and soy diets suppress PTH, and HP attenuates bone turnover and increases vBMD regardless of FR, although these differences do not affect bone strength. The effects of HP and soy may be due in part to enhanced intestinal calcium transporter expression.
C1 [Gaffney-Stomberg, Erin; Lin, Gregory G.; Wulff, Charles R.; Murphy, Nancy E.; Young, Andrew J.; McClung, James P.; Pasiakos, Stefan M.] US Army Res Inst Environm Med, Mil Nutr Div, Natick, MA 01760 USA.
[Cao, Jay J.] USDA ARS, Grand Forks Human Nutr Res Ctr, Grand Forks, ND 58202 USA.
RP Pasiakos, SM (reprint author), US Army Res Inst Environm Med, Mil Nutr Div, Natick, MA 01760 USA.
EM stefan.pasiakos@us.army.mil
RI Pasiakos, Stefan/E-6295-2014
OI Pasiakos, Stefan/0000-0002-5378-5820
FU U.S. Army Military Research and Material Command; Dairy Research
Institute; USDA Agricultural Research Service program
[5450-51000-046-00D]
FX Supported in part by the U.S. Army Military Research and Material
Command, the Dairy Research Institute, and appointments to the U.S. Army
Research Institute of Environmental Medicine administered by the Oak
Ridge Institute for Science and Education (to E G-S., G.G.L., and C R W)
through an interagency agreement between the U.S. Department of Energy
and the U.S. Army Medical Research and Materiel Command. J J.C. was
supported by the USDA Agricultural Research Service program "Bone
Metabolism in Obesity" Current Research Information System no.
5450-51000-046-00D The opinions or assertions contained herein are the
private views of the authors and are not to be construed as official or
as reflecting the views of the Army or the Department of Defense. Any
citations of commercial organizations and trade names in this report do
not constitute an official Department of the Army endorsement of
approval of the products or services of these organizations.
NR 36
TC 4
Z9 6
U1 1
U2 8
PU AMER SOC NUTRITION-ASN
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0022-3166
EI 1541-6100
J9 J NUTR
JI J. Nutr.
PD JUN
PY 2014
VL 144
IS 6
BP 821
EP 829
DI 10.3945/jn.113.188532
PG 9
WC Nutrition & Dietetics
SC Nutrition & Dietetics
GA AH9LZ
UT WOS:000336465200006
PM 24717364
ER
PT J
AU Sions, JM
Velasco, TO
Teyhen, DS
Hicks, GE
AF Sions, J. Megan
Velasco, Teonette O.
Teyhen, Deydre S.
Hicks, Gregory E.
TI Ultrasound Imaging: Intraexaminer and Interexaminer Reliability for
Multifidus Muscle Thickness Assessment in Adults Aged 60 to 85 Years
Versus Younger Adults
SO JOURNAL OF ORTHOPAEDIC & SPORTS PHYSICAL THERAPY
LA English
DT Article
DE aging/geriatrics; lumbar spine; multifidus; ultrasonography
ID LOW-BACK-PAIN; CROSS-SECTIONAL AREA; INTERRATER RELIABILITY; TRANSVERSUS
ABDOMINIS; OLDER-ADULTS; CONTRACTION; REPRODUCIBILITY; INTRARATER;
EXTENSION; MOBILITY
AB STUDY DESIGN: Intraexaminer and interexaminer, within- and between-day reliability study.
OBJECTIVES: To compare the intraexaminer and interexaminer procedural reliability of ultrasound imaging (USI) thickness measurements of the lumbar multifidus muscle at rest and during a contralateral lower-limb lift (CLL) between older (60-85 years of age) and younger (18:40 years of age) adults.
BACKGROUND: Among younger adults, USI has been shown to be reliable and valid for assessing multifidus thickness. Older adults present with age-related changes that may impact assessment. To our knowledge, no USI studies have focused on establishing reliability for multifidus thickness assessments in older adults.
METHODS: Two examiners performed assessments of lumbar multifidus thickness at rest and during a CLL in 30 older and 31 younger adults. Intraclass correlation coefficient (ICC) with 95% confidence interval, standard error of measurement, 95% minimal detectable change for resting and during the CLL, and percent thickness change were calculated.
RESULTS: Within-day interexaminer procedural reliability for multifidus thickness measurements was similar among younger (ICC = 0.90-0.92) and older adults (ICC = 0.86-0.90), as was between-day intraexaminer and interexaminer reliability (younger adults, ICC = 0.84-0.94; older adults, ICC = 0.860.93). Throughout, estimates of percent thickness change were inconsistent (ICC = 0.31-0.86), and standard errors of measurement and minimal detectable changes were larger for older adults.
CONCLUSION: Ultrasound imaging reliability for measurements of multifidus thickness at rest and during a CLL among older adults is consistent with previously published findings for younger adults. Among older adults, it may be preferable to have a single examiner conduct USI assessments.
C1 [Sions, J. Megan; Velasco, Teonette O.; Hicks, Gregory E.] Univ Delaware, Dept Phys Therapy, Newark, DE 19713 USA.
[Teyhen, Deydre S.] US Army Med Res & Mat Command, Telemed & Adv Technol Res Ctr, Ft Detrick, MD USA.
RP Sions, JM (reprint author), Univ Delaware, 540 South Coll Ave,Suite 144A, Newark, DE 19713 USA.
EM megsions@udel.edu
FU Foundation for Physical Therapy PODS I/II; University of Delaware Office
of Graduate Studies [R21 HD057274, 1R01AG041202-01]; NICHD [R21
HD057274, 1R01AG041202-01]
FX The work of Dr Sims is supported in part by the Foundation for Physical
Therapy PODS I/II, the University of Delaware Office of Graduate
Studies, R21 HD057274 (IVICHD), and 1R01AG041202-01 (NIA). The work of
Dr Velasco and Dr Hicks is supported in part by R21 HD057274 (NICHD) and
1R01AG041202-01 (NIA).
NR 34
TC 5
Z9 5
U1 1
U2 3
PU J O S P T,
PI ALEXANDRIA
PA 1111 NORTH FAIRFAX ST, STE 100, ALEXANDRIA, VA 22314-1436 USA
SN 0190-6011
J9 J ORTHOP SPORT PHYS
JI J. Orthop. Sports Phys. Ther.
PD JUN
PY 2014
VL 44
IS 6
BP 425
EP 434
DI 10.2519/jospt.2014.4584
PG 10
WC Orthopedics; Rehabilitation; Sport Sciences
SC Orthopedics; Rehabilitation; Sport Sciences
GA AI2RL
UT WOS:000336705700005
PM 24766356
ER
PT J
AU Ray, DM
Roediger, PA
Neyer, BT
AF Ray, Douglas M.
Roediger, Paul A.
Neyer, Barry T.
TI Commentary: Three-phase optimal design for sensitivity experiments
SO JOURNAL OF STATISTICAL PLANNING AND INFERENCE
LA English
DT Editorial Material
ID QUANTAL RESPONSE CURVES; SEQUENTIAL ESTIMATION
C1 [Ray, Douglas M.] US Army ARDEC, Picatinny Arsenal, NJ 07806 USA.
[Roediger, Paul A.] UTRS Inc, Picatinny Arsenal, NJ 07806 USA.
[Neyer, Barry T.] Excelitas Technol Corp, Miamisburg, OH 45342 USA.
RP Ray, DM (reprint author), US Army ARDEC, Picatinny Arsenal, NJ 07806 USA.
EM douglas.m.ray.civ@mail.mil; paul.a.roediger.ctr@mail.mil;
Barry.Neyer@excelitas.com
NR 16
TC 1
Z9 1
U1 0
U2 1
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-3758
EI 1873-1171
J9 J STAT PLAN INFER
JI J. Stat. Plan. Infer.
PD JUN
PY 2014
VL 149
BP 20
EP 25
DI 10.1016/j.jspi.2013.12.010
PG 6
WC Statistics & Probability
SC Mathematics
GA AI2RM
UT WOS:000336705800003
ER
PT J
AU Theeler, BJ
Ellezam, B
Sadighi, ZS
Mehta, V
Tran, MD
Adesina, AM
Bruner, JM
Puduvalli, VK
AF Theeler, Brett J.
Ellezam, Benjamin
Sadighi, Zsila S.
Mehta, Vidya
Tran, M. Diep
Adesina, Adekunle M.
Bruner, Janet M.
Puduvalli, Vinay K.
TI Adult pilocytic astrocytomas: clinical features and molecular analysis
SO NEURO-ONCOLOGY
LA English
DT Article
DE BRAF mutation; low-grade astrocytoma; pilocytic astrocytoma
ID BRAF FUSION GENE; DIFFUSE GLIOMAS; LEPTOMENINGEAL DISSEMINATION;
MUTATION; FREQUENT; PATHWAY; DUPLICATION; ACTIVATION; PREDICTS; CHILDREN
AB Adult pilocytic astrocytomas (PAs) are rare and have an aggressive clinical course compared with pediatric patients. Constitutive Ras/RAF/MAPK signaling appears to be an important oncogenic event in sporadic PA. We evaluated clinical data and molecular profiles of adult PAs at our institution.
We identified 127 adult PAs in our institutional database. Cases with available tissue were tested for BRAF-KIAA1549 fusion/duplication (B-K fusion) by fluorescence in situ hybridization and submitted for mutation profiling using the Sequenom mutation profiling panel. Subgroup analyses were performed based on clinical and molecular data.
The majority of adult PAs are supratentorial. Twenty-two percent of cases had an initial pathologic diagnosis discordant with the diagnosis made at our institution. Recurrence was seen in 42% of cases, and 13% of patients died during follow-up. Adjuvant radiotherapy following surgical resection was associated with a statistically significant decrease in progression-free survival (P = .004). B-K fusion was identified in 20% (9 of 45) of patients but was not associated with outcome. No BRAF V600E mutations (0 of 40 tested) were found.
This was the largest single institution series of adult PA. A significant proportion of adult PAs follow an aggressive clinical course. Our results support a period of observation following biopsy or surgical resection. B-K fusion in adult PA does not influence outcome, and BRAF V600E mutation appears to be a very rare event. Further study of tumor biology and optimal treatment is needed, given a more aggressive clinical behavior.
C1 [Theeler, Brett J.] Walter Reed Natl Mil Med Ctr, Dept Neurol, Bethesda, MD USA.
[Theeler, Brett J.] Walter Reed Natl Mil Med Ctr, John P Murtha Canc Ctr, Bethesda, MD USA.
[Ellezam, Benjamin] Univ Montreal, Dept Pathol, CHU St Justine, Montreal, PQ H3C 3J7, Canada.
[Sadighi, Zsila S.] St Jude Childrens Res Hosp, Memphis, TN 38105 USA.
[Mehta, Vidya; Tran, M. Diep; Adesina, Adekunle M.] Texas Childrens Hosp, Dept Pathol, Houston, TX 77030 USA.
[Mehta, Vidya; Tran, M. Diep; Adesina, Adekunle M.] Baylor Coll Med, Houston, TX 77030 USA.
[Bruner, Janet M.] Univ Texas MD Anderson Canc Ctr, Dept Pathol, Houston, TX 77030 USA.
[Puduvalli, Vinay K.] Ohio State Univ, Dept Neurosurg, Arthur G James Canc Hosp, Columbus, OH 43210 USA.
RP Theeler, BJ (reprint author), US Army, Med Corps, Dept Neurol, 8901 Wisconsin Ave,Bldg 19,6th Floor, Bethesda, MD 20889 USA.
EM btheeler@hotmail.com
RI Puduvalli, Vinay/A-2411-2016
FU Ferenc and Phyllis Gyorkey Endowed Chair in Pathology of The University
of Texas MD Anderson Cancer Center
FX Supported in part by the Ferenc and Phyllis Gyorkey Endowed Chair in
Pathology of The University of Texas MD Anderson Cancer Center (JMB).
NR 39
TC 7
Z9 7
U1 1
U2 4
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 1522-8517
EI 1523-5866
J9 NEURO-ONCOLOGY
JI Neuro-Oncology
PD JUN
PY 2014
VL 16
IS 6
BP 841
EP 847
DI 10.1093/neuonc/not246
PG 7
WC Oncology; Clinical Neurology
SC Oncology; Neurosciences & Neurology
GA AH9WO
UT WOS:000336496000015
PM 24470550
ER
PT J
AU Ressler, KJ
Schoomaker, EB
AF Ressler, Kerry J.
Schoomaker, Eric B.
TI Army STARRS: A Framingham-Like Study of Psychological Health Risk
Factors in Soldiers
SO PSYCHIATRY-INTERPERSONAL AND BIOLOGICAL PROCESSES
LA English
DT Editorial Material
ID MENTAL-DISORDERS; US MILITARY; RESILIENCE; SUICIDE; DESIGN
C1 [Ressler, Kerry J.] Emory Univ, Howard Hughes Med Inst, Atlanta, GA 30329 USA.
[Schoomaker, Eric B.] US Army, Adelphi, MD 20783 USA.
[Schoomaker, Eric B.] Uniformed Serv Univ Hlth Sci, US Army Med Command, Bethesda, MD 20814 USA.
RP Ressler, KJ (reprint author), Emory Univ, Yerkes Res Ctr, 954 Gatewood Rd NE, Atlanta, GA 30329 USA.
EM kressle@emory.edu
FU Howard Hughes Medical Institute; NIMH NIH HHS [MH096764, MH071537,
MH094757]
NR 22
TC 1
Z9 1
U1 2
U2 7
PU GUILFORD PUBLICATIONS INC
PI NEW YORK
PA 72 SPRING STREET, NEW YORK, NY 10012 USA
SN 0033-2747
J9 PSYCHIATRY
JI Psychiatry-Interpers. Biol. Process.
PD SUM
PY 2014
VL 77
IS 2
BP 120
EP 129
PG 10
WC Psychiatry
SC Psychiatry
GA AI1VD
UT WOS:000336642400002
PM 24865196
ER
PT J
AU Tokish, JM
AF Tokish, John M.
TI Acquired and Adaptive Changes in the Throwing Athlete: Implications on
the Disabled Throwing Shoulder
SO SPORTS MEDICINE AND ARTHROSCOPY REVIEW
LA English
DT Review
DE throwing shoulder; humeral torsion; GIRD; internal impingement; TAM;
throwing adaptations
ID PROFESSIONAL BASEBALL PITCHERS; INTERNAL-ROTATION DEFICIT; GLENOHUMERAL
RANGE; HUMERAL RETROVERSION; ECCENTRIC EXERCISE; MOTION DEFICITS;
PASSIVE RANGE; KINETIC CHAIN; PITCHING ARM; PLAYERS
AB The throwing shoulder continues to be one of the most actively studied and poorly understood aspects of sports medicine. The act of throwing itself transfers tremendous power throughout the kinetic chain, resulting in forces experienced in the shoulder that can exceed its physiologic limits. These forces over time lead to many adaptive changes in the bone, capsule, and muscular structures of the shoulder girdle. An understanding of these acquired changes is critical to differentiate between normal or protective adaptation and pathologic change. The purposes of this article were to elucidate the adaptive and acquired changes, which commonly develop in the throwing shoulder, to explain how these changes contribute in both protective and pathologic roles, and to apply these principles into a deeper understanding of the care of the disabled throwing shoulder.
C1 [Tokish, John M.] Tripler Army Med Ctr, Orthopaed Surg Residency Program, Honolulu, HI 96859 USA.
RP Tokish, JM (reprint author), Tripler Army Med Ctr, MCHK DSO Orthopaed Surg, 1 Jarrett White Rd, Honolulu, HI 96859 USA.
NR 51
TC 1
Z9 1
U1 1
U2 10
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1062-8592
EI 1538-1951
J9 SPORTS MED ARTHROSC
JI Sports Med. Arthrosc. Rev.
PD JUN
PY 2014
VL 22
IS 2
BP 88
EP 93
DI 10.1097/JSA.0000000000000015
PG 6
WC Sport Sciences
SC Sport Sciences
GA AH9ZS
UT WOS:000336506000004
PM 24787722
ER
PT J
AU Naluyima, P
Eller, MA
Laeyendecker, O
Quinn, TC
Serwadda, D
Sewankambo, NK
Gray, RH
Michael, NL
Wabwire-Mangen, F
Robb, ML
Sandberg, JK
AF Naluyima, Prossy
Eller, Michael A.
Laeyendecker, Oliver
Quinn, Thomas C.
Serwadda, David
Sewankambo, Nelson K.
Gray, Ronald H.
Michael, Nelson L.
Wabwire-Mangen, Fred
Robb, Merlin L.
Sandberg, Johan K.
TI Impaired natural killer cell responses are associated with loss of the
highly activated NKG2AR CD57 R CD56 dim subset in HIV-1 subtype D
infection in Uganda
SO AIDS
LA English
DT Article
DE AIDS; CD57; HIV-1; immune activation; natural killer cells; NKG2A;
subtype D
ID VIRUS TYPE-1 INFECTION; KIR3DL1(+) NK CELLS; DENDRITIC CELLS; INNATE
IMMUNITY; RAKAI DISTRICT; T-CELLS; HLA-B; EXPRESSION; DIVERSITY;
PATTERNS
AB Objective:Of the predominant HIV-1 subtypes in Uganda, subtype D infection confers a worse prognosis. HIV-1 infection causes perturbations to natural killer (NK) cells, and yet these cells can exert immune pressure on the virus and influence clinical outcome. Here, we studied NK cell activation and function in Ugandans with chronic untreated HIV-1 subtype D infection in comparison to uninfected community matched controls.Methods:Cryopreserved peripheral blood mononuclear cells (PBMCs) from 42 HIV-infected individuals and 28 HIV-negative controls were analysed using eight-colour flow cytometry. NK cell surface expression of CD16, CD56, CD57, HLA-DR and NKG2A were used to investigate activation, maturation and differentiation status. NK cell function was evaluated by measuring interferon-gamma (IFN) production in response to K562 cells, or interleukin (IL)-12 and IL-18.Results:CD56(dim) NK cells from HIV-infected individuals produced less IFN in response to IL-12 and IL-18 than did CD56(dim) NK cells from uninfected controls. Infected individuals had lower levels of CD56(dim) NK cells coexpressing the differentiation markers NKG2A and CD57 than controls. In addition, their NKG2A(+)CD57(+) CD56(dim) NK cells displayed elevated activation levels as assessed by HLA-DR expression. Cytokine-induced IFN production correlated directly with coexpression of CD57 and NKG2A on CD56(dim) NK cells.Conclusion:HIV-1 subtype D infection is associated with impaired NK cell responsiveness to cytokines, decline of the NKG2A(+)CD57(+) CD56(dim) NK cell subset, as well as elevated activation in this subset. These alterations within the NK cell compartment may contribute to immunopathogenesis of HIV-1 subtype D infection in Ugandans.
C1 [Naluyima, Prossy; Wabwire-Mangen, Fred] Makerere Univ Walter Reed Project, Kampala, Uganda.
[Naluyima, Prossy; Sandberg, Johan K.] Karolinska Univ Hosp Huddinge, Karolinska Inst, Ctr Infect Med, Dept Med, S-14186 Stockholm, Sweden.
[Eller, Michael A.; Michael, Nelson L.; Robb, Merlin L.] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD USA.
[Eller, Michael A.; Robb, Merlin L.] Henry M Jackson Fdn Adv Mil Med, Bethesda, MD USA.
[Laeyendecker, Oliver; Quinn, Thomas C.] NIAID, Div Intramural Res, Immunoregulat Lab, NIH, Bethesda, MD 20892 USA.
[Laeyendecker, Oliver; Quinn, Thomas C.] Johns Hopkins Univ, Sch Med, Baltimore, MD USA.
[Serwadda, David; Wabwire-Mangen, Fred] Makerere Univ, Coll Hlth Sci, Sch Publ Hlth, Kampala, Uganda.
[Serwadda, David; Sewankambo, Nelson K.] Uganda Virus Res Inst, Rakai Hlth Sci Program, Entebbe, Uganda.
[Sewankambo, Nelson K.] Makerere Univ, Coll Hlth Sci, Fac Med, Kampala, Uganda.
[Gray, Ronald H.] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Baltimore, MD USA.
RP Sandberg, JK (reprint author), Karolinska Univ Hosp Huddinge, Karolinska Inst, Ctr Infect Med, Dept Med, F59, S-14186 Stockholm, Sweden.
EM johan.sandberg@ki.se
FU Henry M. Jackson Foundation for the Advancement of Military Medicine,
Inc. [W81XWH-07-2-0067]; U.S. Department of Defense; National Institute
of Allergy and Infectious Diseases (NIAID) [R01 AI34826, R01 AI34265];
National Institute of Child and Health Development [5P30HD06826];
Fogarty Foundation [5D43TW00010]; Swedish Research Council; Swedish
Cancer Society; Stockholm County Council; Karolinska Institutet;
Division of Intramural Research, NIAID, NIH
FX Primary support was provided by a cooperative agreement
(W81XWH-07-2-0067) between the Henry M. Jackson Foundation for the
Advancement of Military Medicine, Inc., and the U.S. Department of
Defense. Data collection was supported, in part, by grants R01 AI34826
and R01 AI34265 from the National Institute of Allergy and Infectious
Diseases (NIAID); grant 5P30HD06826 from the National Institute of Child
and Health Development; grant 5D43TW00010 from the Fogarty Foundation.
Additional support was provided by the Swedish Research Council, the
Swedish Cancer Society, the Stockholm County Council, Karolinska
Institutet and the Division of Intramural Research, NIAID, NIH.
NR 39
TC 4
Z9 4
U1 0
U2 7
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0269-9370
EI 1473-5571
J9 AIDS
JI Aids
PD JUN 1
PY 2014
VL 28
IS 9
BP 1273
EP 1278
DI 10.1097/QAD.0000000000000286
PG 6
WC Immunology; Infectious Diseases; Virology
SC Immunology; Infectious Diseases; Virology
GA AH2SX
UT WOS:000335972500004
PM 24959961
ER
PT J
AU Islam, D
Ruamsap, N
Khantapura, P
Aksomboon, A
Srijan, A
Wongstitwilairoong, B
Bodhidatta, L
Gettayacamin, M
Venkatesan, MM
Mason, CJ
AF Islam, Dilara
Ruamsap, Nattaya
Khantapura, Patchariya
Aksomboon, Ajchara
Srijan, Apichai
Wongstitwilairoong, Boonchai
Bodhidatta, Ladaporn
Gettayacamin, Montip
Venkatesan, Malabi M.
Mason, Carl J.
TI Evaluation of an intragastric challenge model for Shigella dysenteriae 1
in rhesus monkeys (Macaca mulatta) for the pre-clinical assessment of
Shigella vaccine formulations
SO APMIS
LA English
DT Article
DE Shigellosis; rhesus monkey (Macaca mulatta); challenge model
ID FLEXNERI INFECTION; ANIMAL-MODEL; ESCHERICHIA-COLI; RECTAL MUCOSA;
GUINEA-PIG; DISEASE; PATHOGENESIS; ANTIGEN; DIARRHEA; CELLS
AB Shigellosis is a worldwide disease, characterized by abdominal pain, fever, vomiting, and the passage of blood- and mucus-streaked stools. Rhesus monkeys and other primates are the only animals that are naturally susceptible to shigellosis. A suitable animal model is required for the pre-clinical evaluation of vaccines candidates. In this study, the minimal dose of Shigella dysenteriae1 1617 strain required to produce dysentery in four of five (80% attack rate) monkeys using an escalating dose range for three groups [2x10(8), 2x10(9) and 2x10(10) colony forming unit (CFU)] was determined. In addition, the monkeys were re-infected. The identified optimal challenge dose was 2x10(9) CFU; this dose elicited 60% protection in monkeys when they were re-challenged with a one log higher dose (2x10(10) CFU). The challenge dose, 2x10(10) CFU, produced severe dysentery in all monkeys, with one monkey dying within 24h, elicited 100% protection when re-challenged with the same dose. All monkeys exhibited immune responses. This study concludes that the rhesus monkey model closely mimics the disease and immune response seen in humans and is a suitable animal model for the pre-clinical evaluation of Shigella vaccine candidates. Prior infection with the 1617 strain can protect monkeys against subsequent re-challenges with homologous strains.
C1 [Islam, Dilara; Ruamsap, Nattaya; Khantapura, Patchariya; Aksomboon, Ajchara; Srijan, Apichai; Wongstitwilairoong, Boonchai; Bodhidatta, Ladaporn; Mason, Carl J.] AFRIMS, Dept Enter Dis, Bangkok 10400, Thailand.
[Gettayacamin, Montip] AFRIMS, Dept Vet Med, Bangkok 10400, Thailand.
[Venkatesan, Malabi M.] Walter Reed Army Inst Res, Silver Spring, MD USA.
RP Islam, D (reprint author), AFRIMS, Dept Enter Dis, 315-6 Rachawithi Rd, Bangkok 10400, Thailand.
EM islamd@afrims.org
OI MASON, CARL/0000-0002-3676-2811
FU National Institute of Allergy and Infectious Diseases (NIAID) under IAA
[Y1-AI-4906-03]; Department of Defense, US Army Medical and Materiel
Development Command (USAMRMC)
FX The authors thank the laboratory staff in the Department of Enteric
Diseases and in the Department of Veterinary Medicine, AFRIMS, for their
contribution to this study. This work was supported by the National
Institute of Allergy and Infectious Diseases (NIAID), under IAA #
Y1-AI-4906-03, and by the Department of Defense, US Army Medical and
Materiel Development Command (USAMRMC).
NR 55
TC 3
Z9 3
U1 0
U2 2
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0903-4641
EI 1600-0463
J9 APMIS
JI APMIS
PD JUN
PY 2014
VL 122
IS 6
BP 463
EP 475
DI 10.1111/apm.12168
PG 13
WC Immunology; Microbiology; Pathology
SC Immunology; Microbiology; Pathology
GA AH9FN
UT WOS:000336447200001
PM 24028276
ER
PT J
AU Filan, E
Abbas, M
AF Filan, Eamon
Abbas, Mazen
TI Abdominal Pain, Fever, and Infection Secondary to an Unusual Source in a
Previously Healthy Child
SO CLINICAL PEDIATRICS
LA English
DT Editorial Material
ID PERITONITIS; APPENDICITIS
C1 [Filan, Eamon; Abbas, Mazen] Tripler Army Med Ctr, Honolulu, HI 96859 USA.
RP Filan, E (reprint author), Tripler Army Med Ctr, Dept Pediat, MCHK PE, 1 Jarrett White Rd, Honolulu, HI 96859 USA.
EM eamon.l.filan.mil@mail.mil
NR 10
TC 0
Z9 0
U1 0
U2 0
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0009-9228
EI 1938-2707
J9 CLIN PEDIATR
JI Clin. Pediatr.
PD JUN
PY 2014
VL 53
IS 6
BP 607
EP 609
DI 10.1177/0009922814526987
PG 3
WC Pediatrics
SC Pediatrics
GA AG9TP
UT WOS:000335763000017
PM 24634431
ER
PT J
AU Torrealday, S
AF Torrealday, Saioa
TI Is the fertility treatment itself a risk factor for early pregnancy
loss?
SO CURRENT OPINION IN OBSTETRICS & GYNECOLOGY
LA English
DT Review
DE assisted reproductive technology; early pregnancy loss; fertility
treatment; spontaneous abortion
ID ASSISTED REPRODUCTIVE TECHNOLOGY; INTRAUTERINE INSEMINATION; CLOMIPHENE
CITRATE; SPONTANEOUS-ABORTION; CHROMOSOME-ABNORMALITIES; OVARIAN
HYPERSTIMULATION; OVULATION INDUCTION; INFERTILE WOMEN; MISCARRIAGE;
CONCEPTION
AB Purpose of reviewWith the recent advancements in reproductive medicine, many infertile couples now have the opportunity to conceive their own biological children. Although some medication protocols, such as clomiphene citrate, have been utilized for decades, other treatment modalities have evolved over the recent years. It therefore becomes imperative to assess the outcomes of these modalities and be critical regarding their safety. Pregnancy loss is one outcome that can affect many couples who conceive both spontaneously and with assistance via fertility treatment. In this review, several of the most commonly used fertility treatments will be discussed and the impact, if any, they may have in early pregnancy loss will be addressed.Recent findingsCurrent data do not support that notion that infertility treatments or assisted reproductive techniques contribute to early pregnancy loss. However, more studies are needed to eliminate the confounding variables that make data interpretation difficult to generalize to the infertile population.SummaryAn early pregnancy loss can cause emotional distress and grief, particularly for couples already dealing with an infertility diagnosis. Therefore, knowledge regarding the relationship between infertility and early pregnancy loss is vital in order to properly counsel the couple prior to starting treatment.
C1 Womack Army Med Ctr, Dept Obstet & Gynecol, Ft Bragg, NC 28301 USA.
RP Torrealday, S (reprint author), Womack Army Med Ctr, Dept Obstet & Gynecol, Ft Bragg, NC 28301 USA.
EM saioa.torrealday.mil@mail.mil
NR 58
TC 1
Z9 1
U1 0
U2 6
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1040-872X
EI 1473-656X
J9 CURR OPIN OBSTET GYN
JI Curr. Opin. Obstet. Gynecol.
PD JUN
PY 2014
VL 26
IS 3
BP 174
EP 180
DI 10.1097/GCO.0000000000000064
PG 7
WC Obstetrics & Gynecology
SC Obstetrics & Gynecology
GA AH1PF
UT WOS:000335892600008
PM 24752000
ER
PT J
AU Stanley, JK
Coleman, JG
Brasfield, SM
Bednar, AJ
Ang, CY
AF Stanley, Jacob K.
Coleman, Jessica G.
Brasfield, Sandra M.
Bednar, Anthony J.
Ang, Choo Y.
TI ENVIRONMENTAL ASSESSMENT OF DEPLETED URANIUM USED IN MILITARY
ARMOR-PIERCING ROUNDS IN TERRESTRIAL SYSTEMS
SO ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY
LA English
DT Article
DE Depleted uranium; Terrestrial invertebrate toxicology; Earthworm;
Behavioral toxicology; Isopod
ID ECOLOGICAL RISK-ASSESSMENT; EISENIA-FOETIDA; SOIL; EARTHWORMS; TOXICITY;
CONTAMINATION; BIOACCUMULATION; REMEDIATION; EFFICIENCY; KOSOVO
AB Depleted uranium (DU) from the military testing and use of armor-piercing kinetic energy penetrators has been shown to accumulate in soils; however, little is known about the toxicity of DU geochemical species created through corrosion or weathering. The purpose of the present study was to assess the toxic effects and bioaccumulation potential of field-collected DU oxides to the model terrestrial invertebrates Eisenia fetida (earthworm) and Porcellio scaber (isopod). Earthworm studies were acute (72 h) dermal exposures or 28-d spiked soil exposures that used noncontaminated field-collected soils from the US Army's Yuma and Aberdeen Proving Grounds. Endpoints assessed in earthworm testing included bioaccumulation, growth, reproduction, behavior (soil avoidance), and cellular stress (neutral red uptake in coelomocytes). Isopod testing used spiked food, and endpoints assessed included bioaccumulation, survival, and feeding behavior. Concentration-dependent bioaccumulation of DU in earthworms was observed with a maximum bioaccumulation factor of 0.35; however, no significant reductions in survival or impacts to cellular stress were observed. Reproduction lowest-observed-effect concentrations (LOEC) of 158 mg/kg and 96 mg/kg were observed in Yuma Proving Ground and a Mississippi reference soil (Karnac Ferry), respectively. Earthworm avoidance of contaminated soils was not observed in 48-h soil avoidance studies; however, isopods were shown to avoid food spiked with 12.7% by weight DU oxides through digital tracking studies. Environ Toxicol Chem 2014;33:1308-1314. (c) 2014 SETAC
C1 [Stanley, Jacob K.; Coleman, Jessica G.; Brasfield, Sandra M.; Bednar, Anthony J.] US Army, Engn Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA.
[Ang, Choo Y.] Badger Tech Serv, Vicksburg, MS USA.
RP Stanley, JK (reprint author), US Army, Engn Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA.
EM jacob.k.stanley@us.army.mil
NR 33
TC 1
Z9 1
U1 2
U2 32
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0730-7268
EI 1552-8618
J9 ENVIRON TOXICOL CHEM
JI Environ. Toxicol. Chem.
PD JUN
PY 2014
VL 33
IS 6
BP 1308
EP 1314
DI 10.1002/etc.2551
PG 7
WC Environmental Sciences; Toxicology
SC Environmental Sciences & Ecology; Toxicology
GA AH2FM
UT WOS:000335936900001
PM 24549573
ER
PT J
AU Richmond, MC
Serkowski, JA
Ebner, LL
Sick, M
Brown, RS
Carlson, TJ
AF Richmond, Marshall C.
Serkowski, John A.
Ebner, Laurie L.
Sick, Mirjam
Brown, Richard S.
Carlson, Thomas J.
TI Quantifying barotrauma risk to juvenile fish during hydro-turbine
passage.
SO FISHERIES RESEARCH
LA English
DT Article
DE Turbine; Hydropower; Fish passage; Salmon; Barotrauma; Computational
fluid dynamics (CFD)
ID SURVIVAL
AB We introduce a method for hydro turbine biological performance assessment (BioPA) to bridge the gap between field and laboratory studies on fish injury and turbine engineering design. Using this method, a suite of biological performance indicators is computed based on simulated data from a computational fluid dynamics (CFD) model of a proposed hydro turbine design. Each performance indicator is a measure of the probability of exposure to a certain dose of an injury mechanism. If the relationship between the dose of an injury mechanism (stressor) and frequency of injury (dose-response) is known from laboratory or field studies, the likelihood of fish injury for a turbine design can be computed from the performance indicator. By comparing the values of the indicators from various turbine designs, engineers and biologists can identify the more-promising designs and operating conditions to minimize hydraulic conditions hazardous to passing fish. In this paper, the BioPA method is applied to estimate barotrauma induced mortal injury rates for Chinook salmon exposed to rapid pressure changes in Kaplan-type hydro turbines. Following the description of the general method, application of the BioPA to estimate the probability of mortal injury from exposure to rapid decompression is illustrated using a Kaplan hydro turbine at the John Day Dam on the Columbia River in the Pacific Northwest region of the USA. The estimated rates of mortal injury increased from 0.3% to 1.7% as discharge through the turbine increased from 334 to 564 m(3)/s for fish assumed to be acclimated to a depth of 5 m. The majority of pressure nadirs occurred immediately below the runner blades, with the lowest values in the gap at the blade tips and just below the leading edge of the blades. Such information can help engineers focus on problem areas when designing new turbine runners to be more fish-friendly than existing units. (C) 2014 Battelle Memorial Institute and Andritz Hydro Limited. Published by Elsevier B.V. All rights reserved.
C1 [Richmond, Marshall C.; Serkowski, John A.] Pacific NW Natl Lab, Earth Syst Sci Div, Hydrol Grp, Richland, WA 99352 USA.
[Ebner, Laurie L.] US Army Corps Engn, Portland, OR USA.
[Sick, Mirjam] Andritz Hydro, Zurich, Switzerland.
[Brown, Richard S.] Pacific NW Natl Lab, Earth Syst Sci Div, Ecol Grp, Richland, WA 99352 USA.
[Carlson, Thomas J.] Pacific NW Natl Lab, Coastal Sci Div, Sequim, WA USA.
RP Richmond, MC (reprint author), POB 999, Richland, WA 99352 USA.
EM marshall.richmond@pnnl.gov
RI Richmond, Marshall/D-3915-2013
OI Richmond, Marshall/0000-0003-0111-1485
FU US Department of Energy; Energy Efficiency and Renewable Energy; Wind
and Water Power Program; Battelle Memorial Institute [DE-AC06-76RLO
1830]
FX This research was supported by the US Department of Energy, Energy
Efficiency and Renewable Energy, Wind and Water Power Program.; We thank
Kenneth Ham of PNNL for assisting with the hydroacoustics data for
estimating vertical fish distribution.; The US Army Corps of Engineers
Turbine Survival Program provided the CFD model results for the John Day
Dam turbine.; Pacific Northwest National Laboratory (PNNL) is operated
for the US Department of Energy by Battelle Memorial Institute under
Contract No. DE-AC06-76RLO 1830.
NR 42
TC 6
Z9 6
U1 5
U2 34
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0165-7836
EI 1872-6763
J9 FISH RES
JI Fish Res.
PD JUN
PY 2014
VL 154
BP 152
EP 164
DI 10.1016/j.flshres.2014.01.007
PG 13
WC Fisheries
SC Fisheries
GA AH4RZ
UT WOS:000336117000016
ER
PT J
AU Cook, KV
Brown, RS
Deng, ZD
Klett, RS
Li, HD
Seaburg, AG
Eppard, MB
AF Cook, Katrina V.
Brown, Richard S.
Deng, Z. Daniel
Klett, Ryan S.
Li, Huidong
Seaburg, Adam G.
Eppard, M. Brad
TI A comparison of implantation methods for large PIT tags or injectable
acoustic transmitters in juvenile Chinook salmon
SO FISHERIES RESEARCH
LA English
DT Article
DE Telemetry; Injection; Salmonid; Surgery; Tagging
ID INTEGRATED TRANSPONDER TAGS; COASTAL CUTTHROAT TROUT; ATLANTIC SALMON;
SWIMMING PERFORMANCE; SURGICAL IMPLANTATION; COLUMBIA RIVER; MAXIMUM
TAG; SURVIVAL; GROWTH; RETENTION
AB The miniaturization of acoustic transmitters may allow greater flexibility in terms of the size and species of fish available to tag. New downsized injectable acoustic tags similar in shape to passive integrated transponder tags can be rapidly injected rather than surgically implanted through a sutured incision. Before wide-scale field use of these injectable transmitters, standard protocols to ensure the most effective and least damaging methods of implantation must be developed. Three implantation methods were tested in various sizes of juvenile Chinook salmon (Oncorhynchus tschawytscha). Methods included a needle bevel-down injection, a needle bevel-up injection with a 90 degrees rotation, and tag implantation through an unsutured incision. Tagged fish were compared to untagged control groups. Weight and wound area were measured at tagging and every week for 3 weeks; holding tanks were checked daily for mortalities and tag losses. No significant differences among treatments were found in tag loss, or survival, but wound area was significantly reduced among fish tagged via an incision and growth was slightly reduced in bevel down fish. Although there were no significant differences, the bevel-up injection trended toward having the worst results in terms of tag loss and wound area and had high mortality. Implantation through an incision resulted in the lowest tag loss but the highest mortality. Fish from the bevel-down treatment group had the least mortality and smaller wound areas than the bevel-up treatment group but also showed reduced growth. Cumulatively, the data suggest that the unsutured incision and bevel-down injection methods were the most effective; the drawbacks of both methods are described in detail. (C) 2014 Elsevier B.V. All rights reserved.
C1 [Cook, Katrina V.; Brown, Richard S.; Klett, Ryan S.] Pacific NW Natl Lab, Ecol Grp, Richland, WA 99352 USA.
[Deng, Z. Daniel; Li, Huidong] Pacific NW Natl Lab, Hydrol Grp, Richland, WA 99352 USA.
[Seaburg, Adam G.] Univ Washington, Sch Aquat & Fishery Sci, Columbia Basin Res, Seattle, WA 98101 USA.
[Eppard, M. Brad] US Army Corps Engineers, Portland, OR 97208 USA.
RP Brown, RS (reprint author), Pacific NW Natl Lab, Ecol Grp, POB 999, Richland, WA 99352 USA.
EM rich.brown@pnnl.gov
RI Deng, Daniel/A-9536-2011
OI Deng, Daniel/0000-0002-8300-8766
NR 56
TC 9
Z9 9
U1 3
U2 39
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0165-7836
EI 1872-6763
J9 FISH RES
JI Fish Res.
PD JUN
PY 2014
VL 154
BP 213
EP 223
DI 10.1016/j.fishres.2013.11.006
PG 11
WC Fisheries
SC Fisheries
GA AH4RZ
UT WOS:000336117000022
ER
PT J
AU Peng, XQ
Perkins, MW
Simons, J
Witriol, AM
Rodriguez, AM
Benjamin, BM
Devorak, J
Sciuto, AM
AF Peng, Xinqi
Perkins, Michael W.
Simons, Jannitt
Witriol, Alicia M.
Rodriguez, Ashley M.
Benjamin, Brittany M.
Devorak, Jennifer
Sciuto, Alfred M.
TI Acute pulmonary toxicity following inhalation exposure to aerosolized VX
in anesthetized rats
SO INHALATION TOXICOLOGY
LA English
DT Article
DE Chemical warfare nerve agents; cholinesterases; inhalation exposure;
respiratory toxicity; VX
ID NERVE AGENT VX; GUINEA-PIGS; RESPIRATORY DYNAMICS; WARFARE AGENTS;
SOMAN; PROTECTION; EXERCISE; ACETYLCHOLINESTERASE; TERRORISM; SARIN
AB This study evaluated acute toxicity and pulmonary injury in rats at 3, 6 and 24 h after an inhalation exposure to aerosolized O-ethyl S-[2-(diisopropylamino) ethyl] methylphosphonothioate (VX). Anesthetized male Sprague-Dawley rats (250-300 g) were incubated with a glass endotracheal tube and exposed to saline or VX (171, 343 and 514 mg x min/m(3) or 0.2, 0.5 and 0.8 LCt(50), respectively) for 10 min. VX was delivered by a small animal ventilator at a volume of 2.5 ml x 70 breaths/minute. All VX-exposed animals experienced a significant loss in percentage body weight at 3, 6, and 24 h post-exposure. In comparison to controls, animals exposed to 514 mg x min/m(3) of VX had significant increases in bronchoalveolar lavage (BAL) protein concentrations at 6 and 24 h post-exposure. Blood acetylcholinesterase (AChE) activity was inhibited dose dependently at each of the times points for all VX-exposed groups. AChE activity in lung homogenates was significantly inhibited in all VX-exposed groups at each time point. All VX-exposed animals assessed at 20 min and 3, 6 and 24 h post-exposure showed increases in lung resistance, which was prominent at 20 min and 3 h post-exposure. Histopathologic evaluation of lung tissue of the 514 mg x min/m(3) VX-exposed animals at 3, 6 and 24 h indicated morphological changes, including perivascular inflammation, alveolar exudate and histiocytosis, alveolar septal inflammation and edema, alveolar epithelial necrosis, and bronchiolar inflammatory infiltrates, in comparison to controls. These results suggest that aerosolization of the highly toxic, persistent chemical warfare nerve agent VX results in acute pulmonary toxicity and lung injury in rats.
C1 [Peng, Xinqi; Perkins, Michael W.; Simons, Jannitt; Witriol, Alicia M.; Rodriguez, Ashley M.; Benjamin, Brittany M.; Devorak, Jennifer; Sciuto, Alfred M.] US Army Med Res Inst Chem Def, Analyt Toxicol Div, Med Toxicol Branch, Aberdeen Proving Ground, MD 21010 USA.
RP Sciuto, AM (reprint author), US Army Med Res Inst Chem Def, Analyt Toxicol Div, 3100 Ricketts Point Rd, Aberdeen Proving Ground, MD 21010 USA.
EM alfred.mario.sciuto@us.army.mil
FU Defense Threat Reduction Agency [RESP.01.10.RC.007]
FX The author has no declaration of interest. The views expressed in this
article are those of the author(s) and do not reflect the official
policy of the Department of Army, Department of Defense, or the U.S.
Government. The project described was supported by Defense Threat
Reduction Agency (RESP.01.10.RC.007).
NR 35
TC 1
Z9 1
U1 0
U2 17
PU INFORMA HEALTHCARE
PI LONDON
PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND
SN 0895-8378
EI 1091-7691
J9 INHAL TOXICOL
JI Inhal. Toxicol.
PD JUN
PY 2014
VL 26
IS 7
BP 371
EP 379
DI 10.3109/08958378.2014.899410
PG 9
WC Toxicology
SC Toxicology
GA AH8KX
UT WOS:000336387800001
PM 24766293
ER
PT J
AU Borowicz, DT
Bank, LC
AF Borowicz, David T.
Bank, Lawrence C.
TI Web Buckling in Pultruded Fiber-Reinforced Polymer Deep Beams Subjected
to Concentrated Loads
SO JOURNAL OF COMPOSITES FOR CONSTRUCTION
LA English
DT Article
DE Bearing plate; Buckling failure; Concentrated loads; Deep FRP beams;
Digital image correlation
ID DESIGN; TESTS
AB Five 609.5-mm deep fiber-reinforced polymer (FRP) beams with a span-to-depth ratio of 4: 1 were tested in three-point bending with the beam ends constrained to prevent global failure. A concentrated load was applied at midspan either directly to the top flange or through a 101.6 mm wide by 12.7-mm thick FRP bearing plate resting on the top flange. VIC-3D Digital Image Correlation Measurement Software from Correlated Solutions captured out-of-plane displacement of the webs, and Southwell plots were generated to determine buckling loads. Each specimen experienced a stability failure of the web before undergoing material failure in the upper web-flange junction. On average, web buckling occurred at 90% of the ultimate load. The introduction of a bearing plate did not significantly affect the buckling load or ultimate capacity of the specimens. One specimen was tested into the postbuckling range, unloaded, and reloaded to material failure and experienced no loss of strength or stiffness. Another specimen with significant damage to the unloaded web-flange junction was tested and compared with a virgin sample. The damaged sample experienced no significant loss of strength or stiffness. Comparisons of experimental data with three theoretical equations for web-buckling capacity of FRP beams are provided. (C) 2013 American Society of Civil Engineers.
C1 [Borowicz, David T.] US Mil Acad, Dept Civil & Mech Engn, West Point, NY 10996 USA.
[Bank, Lawrence C.] CUNY City Coll, Dept Civil Engn, New York, NY 10031 USA.
RP Borowicz, DT (reprint author), US Mil Acad, Dept Civil & Mech Engn, 752 Thayer Rd,331 Mahan Hall, West Point, NY 10996 USA.
EM david.borowicz@usma.edu; lbank2@ccny.cuny.edu
NR 24
TC 0
Z9 0
U1 3
U2 12
PU ASCE-AMER SOC CIVIL ENGINEERS
PI RESTON
PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA
SN 1090-0268
EI 1943-5614
J9 J COMPOS CONSTR
JI J. Compos. Constr.
PD JUN
PY 2014
VL 18
IS 3
SI SI
AR A4013014
DI 10.1061/(ASCE)CC.1943-5614.0000360
PG 8
WC Engineering, Civil; Mechanics; Materials Science, Composites
SC Engineering; Mechanics; Materials Science
GA AH6OH
UT WOS:000336249800014
ER
PT J
AU Russell, MM
Hsiang, SM
Liu, M
Wambeke, B
AF Russell, Marion M.
Hsiang, Simon M.
Liu, Min
Wambeke, Brad
TI Causes of Time Buffer and Duration Variation in Construction Project
Tasks: Comparison of Perception to Reality
SO JOURNAL OF CONSTRUCTION ENGINEERING AND MANAGEMENT
LA English
DT Article
ID REDUCING VARIABILITY; IMPROVE PERFORMANCE; PRODUCTIVITY; CONTINGENCY;
MOTIVATION; MANAGEMENT; PRINCIPLE; MODEL; RISK
C1 [Russell, Marion M.; Liu, Min] N Carolina State Univ, Dept Civil Construct & Environm Engn, Raleigh, NC 27695 USA.
[Hsiang, Simon M.] Texas Tech Univ, Lubbock, TX 79409 USA.
[Wambeke, Brad] US Mil Acad, Civil & Mech Engn Dept, West Point, NY 10996 USA.
RP Liu, M (reprint author), N Carolina State Univ, Dept Civil Construct & Environm Engn, Raleigh, NC 27695 USA.
EM mmrusse2@ncsu.edu; simon.hsiang@ttu.edu; min_liu@ncsu.edu;
bwwambek@ncsu.edu
NR 39
TC 0
Z9 0
U1 0
U2 4
PU ASCE-AMER SOC CIVIL ENGINEERS
PI RESTON
PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA
SN 0733-9364
EI 1943-7862
J9 J CONSTR ENG M
JI J. Constr. Eng. Manage.
PD JUN 1
PY 2014
VL 140
IS 6
PG 12
WC Construction & Building Technology; Engineering, Industrial;
Engineering, Civil
SC Construction & Building Technology; Engineering
GA AH1KV
UT WOS:000335880000008
ER
PT J
AU Bianchini, A
AF Bianchini, Alessandra
TI Pavement Maintenance Planning at the Network Level with Principal
Component Analysis
SO JOURNAL OF INFRASTRUCTURE SYSTEMS
LA English
DT Article
DE Principal-component analysis; Pavement performance; Flexible pavement
ID STRUCTURAL SYSTEM-IDENTIFICATION; WEIGHT DEFLECTOMETER DEFLECTIONS;
ASPHALT PAVEMENT; PERFORMANCE; PREDICTION; INDICATORS
AB Pavement management relies on the evaluation of the condition of pavement at different times during the life of the structure. The combination of condition indicators and the knowledge of how they are used in any pavement condition model is fundamental for pavement rating. To handle complexity and information redundancy, this paper proposes the principal-component analysis (PCA) to evaluate the relative importance of different types of distresses on the condition assessment for flexible pavements, and to use relevant condition features to establish criteria for pavement management. The important outcomes in applying the PCA approach were: even with the dimensionality reduction dictated by the variance, there was limited loss of information with regard to the section condition that did not affect the overall objective of pavement management; also, information redundancy was minimized. (C) 2013 American Society of Civil Engineers.
C1 US Army, Engn Res & Dev Ctr, Vicksburg, MS 39180 USA.
RP Bianchini, A (reprint author), US Army, Engn Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA.
EM alessandra.bianchini@usace.army.mil
NR 37
TC 3
Z9 3
U1 8
U2 19
PU ASCE-AMER SOC CIVIL ENGINEERS
PI RESTON
PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA
SN 1076-0342
EI 1943-555X
J9 J INFRASTRUCT SYST
JI J. Infrastruct. Syst.
PD JUN 1
PY 2014
VL 20
IS 2
AR 04013013
DI 10.1061/(ASCE)IS.1943-555X.0000189
PG 8
WC Engineering, Civil
SC Engineering
GA AH6QR
UT WOS:000336256300008
ER
PT J
AU Shah, S
Bellam, N
Leipsic, J
Berman, DS
Quyyumi, A
Hausleiter, J
Achenbach, S
Al-Mallah, M
Budoff, MJ
Cademartiri, F
Callister, TQ
Chang, HJ
Chow, BJW
Cury, RC
Delago, AJ
Dunning, AL
Feuchtner, GM
Hadamitzky, M
Karlsberg, RP
Kaufmann, PA
Lin, FY
Chinnaiyan, KM
Maffei, E
Raff, GL
Villines, TC
Gomez, MJ
Min, JK
Shaw, LJ
AF Shah, Sana
Bellam, Naveen
Leipsic, Jonathon
Berman, Daniel S.
Quyyumi, Arshed
Hausleiter, Joerg
Achenbach, Stephan
Al-Mallah, Mouaz
Budoff, Matthew J.
Cademartiri, Fillippo
Callister, Tracy Q.
Chang, Hyuk-Jae
Chow, Benjamin J. W.
Cury, Ricardo C.
Delago, Augustin J.
Dunning, Allison L.
Feuchtner, Gudrun M.
Hadamitzky, Martin
Karlsberg, Ronald P.
Kaufmann, Philipp A.
Lin, Fay Y.
Chinnaiyan, Kavitha M.
Maffei, Erica
Raff, Gilbert L.
Villines, Todd C.
Gomez, Millie J.
Min, James K.
Shaw, Leslee J.
CA CONFIRM COronary CT Angiography Ev
TI Prognostic significance of calcified plaque among symptomatic patients
with nonobstructive coronary artery disease
SO JOURNAL OF NUCLEAR CARDIOLOGY
LA English
DT Article
DE Coronary calcification; prognosis; nonobstructive coronary artery
disease
ID ALL-CAUSE MORTALITY; COMPUTED TOMOGRAPHIC ANGIOGRAPHY; EXPERT CONSENSUS
DOCUMENT; INTRAVASCULAR ULTRASOUND; CARDIOVASCULAR RISK;
AMERICAN-COLLEGE; CALCIUM; CALCIFICATION; ATHEROSCLEROSIS;
QUANTIFICATION
AB Coronary artery calcium (CAC) is a well-established predictor of clinical outcomes for population screening. Limited evidence is available as to its predictive value in symptomatic patients without obstructive coronary artery disease (CAD). The aim of the current study was to assess the prognostic value of CAC scores among symptomatic patients with nonobstructive CAD.
From the COronary Computed Tomographic Angiography EvaluatioN For Clinical Outcomes: An InteRnational Multicenter (CONFIRM) registry, 7,200 symptomatic patients with nonobstructive CAD (< 50% coronary stenosis) on coronary-computed tomographic angiography were prospectively enrolled and followed for a median of 2.1 years. Patients were categorized as without (0% stenosis) or with (> 0% but < 50% coronary stenosis) a luminal stenosis. CAC scores were calculated using the Agatston method. Univariable and multivariable Cox proportional hazard models were employed to estimate all-cause mortality and/or myocardial infarction (MI). Four-year death and death or MI rates were 1.9% and 3.3%.
Of the 4,380 patients with no luminal stenosis, 86% had CAC scores of < 10 while those with a luminal stenosis had more prevalent and extensive CAC with 31.9% having a CAC score of a parts per thousand yen100. Among patients with no luminal stenosis, CAC was not predictive of all-cause mortality (P = .44). However, among patients with a luminal stenosis, 4-year mortality rates ranged from 0.8% to 9.8% for CAC scores of 0 to a parts per thousand yen400 (P < .0001). The mortality hazard was 6.0 (P = .004) and 13.3 (P < .0001) for patients with a CAC score of 100-399 and a parts per thousand yen400. In patients with a luminal stenosis, CAC remained independently predictive in all-cause mortality (P < .0001) and death or MI (P < .0001) in multivariable models containing CAD risk factors and presenting symptoms.
CAC allows for the identification of those at an increased hazard for death or MI in symptomatic patients with nonobstructive disease. From the CONFIRM registry, the extent of CAC was an independent estimator of long-term prognosis among symptomatic patients with luminal stenosis and may further define risk and guide preventive strategies in patients with nonobstructive CAD.
C1 [Shah, Sana; Bellam, Naveen; Quyyumi, Arshed; Shaw, Leslee J.] Emory Univ, Sch Med, Dept Med, Emory Clin Cardiovasc Res Inst, Atlanta, GA 30322 USA.
[Leipsic, Jonathon] Univ British Columbia, St Pauls Hosp, Dept Radiol, Vancouver, BC V5Z 1M9, Canada.
[Berman, Daniel S.; Gomez, Millie J.; Min, James K.] Cedars Sinai Med Ctr, Dept Imaging, Los Angeles, CA 90048 USA.
[Hausleiter, Joerg] Tech Univ Munich, Div Cardiol, D-80290 Munich, Germany.
[Achenbach, Stephan] Univ Giessen, Dept Med, D-35390 Giessen, Germany.
[Al-Mallah, Mouaz] King Abdulaziz Cardiac Ctr, Dept Med, Riyadh, Saudi Arabia.
[Budoff, Matthew J.] Harbor UCLA Med Ctr, Dept Med, Los Angeles, CA USA.
[Cademartiri, Fillippo] Giovanni XXIII Hosp, Cardiovasc Imaging Unit, Monastier Di Treviso, Italy.
[Callister, Tracy Q.] Tennessee Heart & Vasc Inst, Hendersonville, TN USA.
[Chang, Hyuk-Jae] Severance Cardiovasc Hosp, Div Cardiol, Seoul, South Korea.
[Chow, Benjamin J. W.] Univ Ottawa, Inst Heart, Dept Med Cardiol, Ottawa, ON, Canada.
[Cury, Ricardo C.] Baptist Hosp Miami, Miami, FL USA.
[Cury, Ricardo C.] Baptist Cardiac & Vasc Inst, Miami, FL USA.
[Delago, Augustin J.] Capital Cardiol Associates, Albany, NY USA.
[Dunning, Allison L.; Lin, Fay Y.] Weill Cornell Med Coll, Dept Publ Hlth & Med, New York, NY USA.
[Dunning, Allison L.; Lin, Fay Y.] New York Presbyterian Hosp, New York, NY USA.
[Feuchtner, Gudrun M.] Med Univ Innsbruck, Dept Radiol 2, A-6020 Innsbruck, Austria.
[Hadamitzky, Martin] German Heart Ctr, Munich, Germany.
[Karlsberg, Ronald P.] Cardiovasc Med Grp, Beverly Hills, CA USA.
[Kaufmann, Philipp A.] William Beaumont Hosp, Dept Cardiol, Royal Oak, MI 48072 USA.
[Chinnaiyan, Kavitha M.; Raff, Gilbert L.] Univ Zurich Hosp, CH-8091 Zurich, Switzerland.
[Maffei, Erica; Villines, Todd C.] Walter Reed Army Med Ctr, Dept Med, Washington, DC 20307 USA.
RP Shaw, LJ (reprint author), Emory Univ, Sch Med, Dept Med, Emory Clin Cardiovasc Res Inst, 1462 Clifton Rd NE,Room 529, Atlanta, GA 30322 USA.
EM lshaw3@emory.edu
RI Cademartiri, Filippo/H-7336-2015; Maffei, Erica/J-2370-2016;
OI Cademartiri, Filippo/0000-0002-0579-3279; Maffei,
Erica/0000-0002-0388-4433; Al-Mallah, Mouaz/0000-0003-2348-0484
FU Siemens; Bayer Schering Pharma; Bayer Phama; Blue Cross Blue Shield of
Michigan; GE Healthcare; Servier; Siemens Medical Systems
FX The following authors declared conflicts of interest: Stephan Achenbach:
(Grant Support: Siemens and Bayer Schering Pharma; Consultant: Servier);
Mouaz Al-Mallah (Consultant: Astellas); Matthew Budoff (Consultant: GE
Healthcare); Filippo Cademartiri (Speaker's Bureau: Bracco Diagnostics;
Consultant: Guerbet); Kavitha Chinnaiyan (Grant Support: Bayer Phama,
Blue Cross Blue Shield of Michigan); Benjamin Chow (Grant Support and
Consultant: GE Healthcare; Grant Support: Servier; Educational Support:
TeraRecon); Ricardo Cury (Consultant: Astellas Pharma, GE Healthcare,
Novartis); Joerg Hausleiter (Grant Support: Siemens Medical Systems);
Philipp Kaumann (Grant Support: GE Healthcare); Jonathon Leipsic
(Speaker's Bureau: GE Healthcare, Edwards Lifesciences, Heartflow, and
Circle CVI); Gilbert Raff (Grant Support: Siemens, Bayer Pharma). The
remainder of the authors have no disclosures.
NR 33
TC 10
Z9 10
U1 1
U2 1
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1071-3581
EI 1532-6551
J9 J NUCL CARDIOL
JI J. Nucl. Cardiol.
PD JUN
PY 2014
VL 21
IS 3
BP 453
EP 466
DI 10.1007/s12350-014-9865-9
PG 14
WC Cardiac & Cardiovascular Systems; Radiology, Nuclear Medicine & Medical
Imaging
SC Cardiovascular System & Cardiology; Radiology, Nuclear Medicine &
Medical Imaging
GA AH6YI
UT WOS:000336278000005
PM 24683047
ER
PT J
AU Grussing, MN
Liu, LY
AF Grussing, Michael N.
Liu, Liang Y.
TI Knowledge-Based Optimization of Building Maintenance, Repair, and
Renovation Activities to Improve Facility Life Cycle Investments
SO JOURNAL OF PERFORMANCE OF CONSTRUCTED FACILITIES
LA English
DT Article
DE Buildings; Asset management; Condition assessment; Facility life cycle;
Optimization
ID MANAGEMENT
AB Buildings and related civil infrastructure are an important factor of production that contribute directly to the accomplishment of an organization's mission and/or the generation of revenue. Aging, obsolescence, and general deterioration of these buildings, and their systems and components, can adversely affect the ability to accomplish a mission or generate expected revenue, thus resulting in an elevated risk profile. Maintenance, repair, and renovation (MR&R) activities, when planned effectively, can affect performance in such a way to reduce this risk. A rapidly aging infrastructure and building stock in the United States and across the world jeopardizes the ability to generate output and accomplish a mission at status quo. Moreover, rapidly expanding demands on some infrastructure will likewise make the status quo greatly inadequate in the near future. This requires two highly interrelated strategies: (1) to introduce new capabilities and capacities into the infrastructure stock to meet projected demand; and (2) to adequately manage, maintain, improve, and renew the existing infrastructure stock to slow performance degradation and fill demand gaps. The objective of this study is to develop a methodology for rapidly identifying and selecting multiyear building MR&R activities, such that facility performance is maximized and life cycle costs are minimized. This is a significant step toward the development of a comprehensive facility life cycle MR&R model that incorporates infrastructure economics and uncertainty for improved decision making. The result of this study is a model framework, to be applied against a building or group of buildings, which selects the optimum mixture of work activities considering condition, capability, performance, and life cycle costs. A genetic algorithm is employed to optimize the activity selection, and the proposed model approach is implemented against an example building to illustrate the methodology.
C1 [Grussing, Michael N.] US Army Corps Engineers, Engn Res & Dev Ctr, Champaign, IL 61822 USA.
[Liu, Liang Y.] Univ Illinois, Dept Civil & Environm Engn, Urbana, IL 61801 USA.
RP Grussing, MN (reprint author), US Army Corps Engineers, Engn Res & Dev Ctr, Champaign, IL 61822 USA.
EM michael.n.grussing@usace.army.mil
RI Johnson, Marilyn/E-7209-2011
NR 28
TC 3
Z9 3
U1 6
U2 39
PU ASCE-AMER SOC CIVIL ENGINEERS
PI RESTON
PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA
SN 0887-3828
EI 1943-5509
J9 J PERFORM CONSTR FAC
JI J. Perform. Constr. Facil.
PD JUN
PY 2014
VL 28
IS 3
BP 539
EP 548
DI 10.1061/(ASCE)CF.1943-5509.0000449
PG 10
WC Construction & Building Technology; Engineering, Civil
SC Construction & Building Technology; Engineering
GA AH6NE
UT WOS:000336246800013
ER
PT J
AU Mata, DG
Rezk, PE
Sabnekar, P
Cerasoli, DM
Chilukuri, N
AF Mata, David G.
Rezk, Peter E.
Sabnekar, Praveena
Cerasoli, Douglas M.
Chilukuri, Nageswararao
TI Investigation of Evolved Paraoxonase-1 Variants for Prevention of
Organophosphorous Pesticide Compound Intoxication
SO JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
LA English
DT Article
ID HUMAN BUTYRYLCHOLINESTERASE; NERVE AGENTS; GUINEA-PIGS; PROTECTION;
SOMAN; TOXICITY; PON1; PRETREATMENT; PROPHYLAXIS; HYDROLASES
AB We investigated the ability of the engineered paraoxonase-1 variants G3C9, VII-D11, I-F11, and VII-D2 to afford protection against paraoxon intoxication. Paraoxon is the toxic metabolite of parathion, a common pesticide still in use in many developing countries. An in vitro investigation showed that VII-D11 is the most efficient variant at hydrolyzing paraoxon with a k(cat)/K-m of 2.1 Chi 10(6) M-1 min(-1) and 1.6 Chi 10(6) M-1 min(-1) for the enzyme expressed via adenovirus infection of 293A cells and mice, respectively. Compared with the G3C9 parent scaffold, VII-D11 is 15- to 20- fold more efficacious at hydrolyzing paraoxon. Coinciding with these results, mice expressing VII-D11 in their blood survived and showed no symptoms against a cumulative 6.3 Chi LD50 dose of paraoxon, whereas mice expressing G3C9 experienced tremors and only 50% survival. We then determined whether VII-D11 can offer protection against paraoxon when present at substoichiometric concentrations. Mice containing varying concentrations of VII-D11 in their blood ( 0.2-4.1 mg/ml) were challenged with doses of paraoxon at fixed stoichiometric ratios that constitute up to a 10-fold molar excess of paraoxon to enzyme ( 1.4-27 Chi LD50 doses) and were assessed for tremors and mortality. Mice were afforded complete asymptomatic protection below a paraoxon-to-enzyme ratio of 8: 1, whereas higher ratios produced tremors and/or mortality. VII-D11 in mouse blood coeluted with high-density lipoprotein, suggesting an association between the two entities. Collectively, these results demonstrate that VII-D11 is a promising candidate for development as a prophylactic catalytic bioscavenger against organophosphorous pesticide toxicity.
C1 [Mata, David G.; Rezk, Peter E.; Sabnekar, Praveena; Cerasoli, Douglas M.; Chilukuri, Nageswararao] US Army Med Res Inst Chem Def, Div Res, Physiol & Immunol Branch, Aberdeen Proving Ground, MD 21010 USA.
RP Chilukuri, N (reprint author), US Army Med Res Inst Chem Def, Div Res, Physiol & Immunol Branch, 3100 Ricketts Point Rd, Aberdeen Proving Ground, MD 21010 USA.
EM Nageswararao.chilukuri.civ@mail.mil
FU Defense Threat Reduction Agency; Joint Science and Technology Office;
Medical ST Division
FX This research was supported by the Defense Threat Reduction Agency,
Joint Science and Technology Office, Medical S&T Division ( to N.C.).
NR 34
TC 8
Z9 8
U1 1
U2 10
PU AMER SOC PHARMACOLOGY EXPERIMENTAL THERAPEUTICS
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3995 USA
SN 0022-3565
EI 1521-0103
J9 J PHARMACOL EXP THER
JI J. Pharmacol. Exp. Ther.
PD JUN
PY 2014
VL 349
IS 3
BP 549
EP 558
DI 10.1124/jpet.114.213645
PG 10
WC Pharmacology & Pharmacy
SC Pharmacology & Pharmacy
GA AH5GJ
UT WOS:000336156200021
PM 24706983
ER
PT J
AU Meeks, JJ
Kern, SQ
Dalbagni, G
Eastham, JA
Sandhu, JS
AF Meeks, Joshua J.
Kern, Sean Q.
Dalbagni, Guido
Eastham, James A.
Sandhu, Jaspreet S.
TI The Prevalence of Persistent Prostate Cancer after Radiotherapy Detected
at Radical Cystoprostatectomy for Bladder Cancer
SO JOURNAL OF UROLOGY
LA English
DT Article
DE prostatic neoplasms; neoplasm recurrence, local; radiotherapy; urinary
bladder neoplasms; cystectomy
ID BEAM RADIATION-THERAPY; RELAPSE-FREE SURVIVAL; PREDICTIVE-VALUE;
SPECIMENS; OUTCOMES; BIOPSY
AB Purpose: More than half of the men who receive treatment for prostate cancer elect radiotherapy. After radiotherapy recurrence is determined by an increase in prostate specific antigen and not usually by pathological confirmation. We describe the prevalence of persistent gradable prostate cancer in men treated with radiotherapy for prostate cancer at radical cystoprostatectomy for bladder cancer.
Materials and Methods: A total of 78 patients underwent radiotherapy (brachytherapy and/or external beam radiation) before the development of bladder cancer requiring radical cystectomy at our institution. All tissues were evaluated by a specialized genitourinary pathologist.
Results: Median time from radiotherapy to radical cystoprostatectomy was 77 months. Gradable prostate cancer was identified in 45% of patients. Of the tumors 69% were Gleason score 7 or greater, 17% were pT3 or greater and 5% showed positive lymph nodes. Men treated more recently were less likely to have gradable prostate cancer, including 100% before 1980, 49% between 1980 and 2000 and 10% from 2000 to the present (p = 0.002) as were those who received external beam radiation alone compared to brachytherapy and combined brachytherapy/external beam radiation (58% vs 27% and 14%, respectively, p = 0.005).
Conclusions: After radiotherapy 45% of men had persistent prostate cancer (37% of men with no evidence of disease). A decreased prostate cancer rate was associated with later treatment year and combined brachytherapy/external beam radiation regimens. Similar to men treated with radical cystoprostatectomy for muscle invasive bladder cancer, meticulous attention should be paid during prostate removal in men treated with radiotherapy because many may have persistent prostate cancer. In addition, markers other than prostate specific antigen should be studied in men treated with radiotherapy to better identify those with biochemical recurrence.
C1 [Sandhu, Jaspreet S.] Mem Sloan Kettering Canc Ctr, Dept Surg, Urol Serv, New York, NY 10021 USA.
[Kern, Sean Q.] Tripler Army Med Ctr, Dept Surg, Urol Serv, Honolulu, HI 96859 USA.
RP Sandhu, JS (reprint author), Mem Sloan Kettering Canc Ctr, Dept Surg, Urol Serv, 353 East 68th St, New York, NY 10021 USA.
EM sandhuj@mskcc.org
FU Sidney Kimmel Center for Prostate and Urologic Cancers
FX Supported by the Sidney Kimmel Center for Prostate and Urologic Cancers.
NR 15
TC 0
Z9 0
U1 0
U2 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0022-5347
EI 1527-3792
J9 J UROLOGY
JI J. Urol.
PD JUN
PY 2014
VL 191
IS 6
BP 1760
EP 1763
DI 10.1016/j.juro.2013.12.037
PG 4
WC Urology & Nephrology
SC Urology & Nephrology
GA AI0IS
UT WOS:000336531100032
PM 24373801
ER
PT J
AU Wasserberg, G
Kirsch, P
Rowton, ED
AF Wasserberg, G.
Kirsch, P.
Rowton, E. D.
TI Orientation of colonized sand flies Phlebotomus papatasi, P. duboscqi,
and Lutzomyia longipalpis (Diptera: Psychodidae) to diverse honeys using
a 3-chamber in-line olfactometer
SO JOURNAL OF VECTOR ECOLOGY
LA English
DT Article
DE Sand fly; plant-based attractant baits; semiochemicals; olfactory
attraction; leishmaniasis; biological control; area-wide pest management
ID HUBNER LEPIDOPTERA-NOCTUIDAE; VOLATILE-BASED ATTRACTICIDE; JORDAN
VALLEY; CUTANEOUS LEISHMANIASIS; MOSQUITOS DIPTERA; BOTANICAL ORIGIN;
PLANT; SUGAR; SUSCEPTIBILITY; IDENTIFICATION
AB A 3-chamber in-line olfactometer designed for use with sand flies is described and tested as a high-throughput method to screen honeys for attractiveness to Phlebotomus papatasi (four geographic isolates), P. duboscqi (two geographic isolates), and Lutzomyia longipalpis maintained in colonies at the Walter Reed Army Institute of Research. A diversity of unifloral honey odors were evaluated as a proxy for the natural floral odors that sand flies may use in orientation to floral sugar sources in the field. In the 3-chamber in-line olfactometer, the choice modules come directly off both sides of the release area instead of angling away as in the Y-tube olfactometer. Of the 25 honeys tested, five had a significant attraction for one or more of the sand fly isolates tested. This olfactometer and high-throughput method has utility for evaluating a diversity of natural materials with unknown complex odor blends that can then be down-selected for further evaluation in wind tunnels and/or field scenarios.
C1 [Wasserberg, G.] Univ N Carolina, Dept Biol, Greensboro, NC 27402 USA.
[Kirsch, P.] Univ Queensland, Minerals Ind Safety & Hlth Ctr, Brisbane, Qld 4072, Australia.
[Rowton, E. D.] Walter Reed Army Inst Res, Dept Sand Fly Biol, Silver Spring, MD 20910 USA.
RP Wasserberg, G (reprint author), Univ N Carolina, Dept Biol, Greensboro, NC 27402 USA.
EM g_wasser@uncg.edu
FU MIDRP, U.S. Department of Defense
FX This research was funded by MIDRP, U.S. Department of Defense. The
opinions or assertions contained herein are the private views of the
authors and are not to be construed as official or as reflecting true
views of the Department of the Army or the Department of Defense.
NR 45
TC 3
Z9 3
U1 2
U2 20
PU SOC VECTOR ECOLOGY
PI CORONA
PA 1966 COMPTON AVE, CORONA, CA 92881 USA
SN 1081-1710
EI 1948-7134
J9 J VECTOR ECOL
JI J. Vector Ecol.
PD JUN
PY 2014
VL 39
IS 1
BP 94
EP 102
DI 10.1111/j.1948-7134.2014.12075.x
PG 9
WC Entomology
SC Entomology
GA AH3XJ
UT WOS:000336059300012
PM 24820561
ER
PT J
AU Foley, DH
Linton, YM
Ruiz-Lopez, JF
Conn, JE
Sallum, MAM
Povoa, MM
Bergo, ES
Oliveira, TMP
Sucupira, I
Wilkerson, RC
AF Foley, Desmond H.
Linton, Yvonne-Marie
Freddy Ruiz-Lopez, J.
Conn, Jan E.
Sallum, Maria Anice M.
Povoa, Marinete M.
Bergo, Eduardo S.
Oliveira, Tatiane M. P.
Sucupira, Izis
Wilkerson, Richard C.
TI Geographic distribution, evolution, and disease importance of species
within the Neotropical Anopheles albitarsis Group (Diptera, Culicidae)
SO JOURNAL OF VECTOR ECOLOGY
LA English
DT Article
DE Mosquito; ecological niche models; malaria; phylogenetics; SEEVA;
Albitarsis Group
ID COMPARATIVE SUSCEPTIBILITY; PLASMODIUM-FALCIPARUM; CONSERVATION
GENETICS; POPULATION HISTORY; MALARIA VECTORS; NICHE MODELS;
PHYLOGEOGRAPHY; BRAZIL; SPECIATION; TRANSMISSION
AB The Anopheles albitarsis group of mosquitoes comprises eight recognized species and one mitochondrial lineage. Our knowledge of malaria vectorial importance and the distribution and evolution of these taxa is incomplete. We constructed ecological niche models (ENMs) for these taxa and used hypothesized phylogenetic relationships and ENMs to investigate environmental and ecological divergence associated with speciation events. Two major clades were identified, one north (Clade 1) and one south (Clade 2) of the Amazon River that likely is or was a barrier to mosquito movement. Clade 1 species occur more often in higher average temperature locations than Clade 2 species, and taxon splits within Clade 1 corresponded with a greater divergence of variables related to precipitation than was the case within Clade 2. Comparison of the ecological profiles of sympatric species and sister species support the idea that phylogenetic proximity is related to ecological similarity. Anopheles albitarsis I, An. janconnae, and An. marajoara ENMs had the highest percentage of their predicted suitable habitat overlapping distribution models of Plasmodium falciparum and P. vivax, and warrant additional studies of the transmission potential of these species. Phylogenetic proximity may be related to malaria vectorial importance within the Albitarsis Group.
C1 [Foley, Desmond H.; Linton, Yvonne-Marie; Wilkerson, Richard C.] Walter Reed Army Inst Res, Div Entomol, Silver Spring, MD 20910 USA.
[Freddy Ruiz-Lopez, J.] Museum Support Ctr, Smithsonian Inst, Walter Reed Biosystemat Unit, Suitland, MD 20746 USA.
[Freddy Ruiz-Lopez, J.] Univ Antioquia, PECET, Medellin, Colombia.
[Conn, Jan E.] New York State Dept Hlth, Wadsworth Ctr, Albany, NY 12159 USA.
[Conn, Jan E.] SUNY Albany, Sch Publ Hlth, Dept Biomed Sci, Albany, NY 12222 USA.
[Sallum, Maria Anice M.; Oliveira, Tatiane M. P.] Univ Sao Paulo, Fac Saude Publ, Dept Epidemiol, BR-05508 Sao Paulo, Brazil.
[Povoa, Marinete M.; Sucupira, Izis] Inst Evandro Chagas, Ananindeua, Para, Brazil.
[Bergo, Eduardo S.] Superintendencia Controle Endemias Estado Sao Paul, Sao Paulo, Brazil.
RP Foley, DH (reprint author), Walter Reed Army Inst Res, Div Entomol, 503 Robert Grant Ave, Silver Spring, MD 20910 USA.
EM foleydes@si.edu
RI Oliveira, Tatiane/O-6518-2014; Sallum, Maria/B-8537-2012;
OI BERGO, EDUARDO/0000-0003-4928-0368; Conn, Jan/0000-0002-5301-7020;
Foley, Desmond/0000-0001-7525-4601
FU Global Emerging Infections Surveillance and Response System (a Division
of the Armed Forces Health Surveillance Center - AFHSC/Div of GEIS Ops)
[P0149_13_WR]; National Institute of Health, USA [R01 AI50139-02];
Foundation for Research Support of the State of Sao Paulo, FAPESP
[2011/20397-7]; National Research Council Research Associateship Award
at the Walter Reed Army Institute of Research
FX This investigation received financial support from the Global Emerging
Infections Surveillance and Response System (a Division of the Armed
Forces Health Surveillance Center - AFHSC/Div of GEIS Ops) (grant
P0149_13_WR to DHF); from the National Institute of Health, USA (grant
R01 AI50139-02 to JEC); and from the Foundation for Research Support of
the State of Sao Paulo, FAPESP (Processo no. 2011/20397-7 to MAMS). This
manuscript was prepared while YML held a National Research Council
Research Associateship Award at the Walter Reed Army Institute of
Research. We thank Simon Hay, Carlos Guerra, Catherine Moyes, and Peter
Gething of the Malaria Atlas Project for access to malaria models. This
research was performed under a Memorandum of Understanding between the
Walter Reed Army Institute of Research and the Smithsonian Institution,
with institutional support provided by both organizations. The published
material reflects the views of the authors and should not be construed
to represent those of the Department of the Army or the Department of
Defense.
NR 33
TC 6
Z9 6
U1 0
U2 18
PU SOC VECTOR ECOLOGY
PI CORONA
PA 1966 COMPTON AVE, CORONA, CA 92881 USA
SN 1081-1710
EI 1948-7134
J9 J VECTOR ECOL
JI J. Vector Ecol.
PD JUN
PY 2014
VL 39
IS 1
BP 168
EP 181
DI 10.1111/j.1948-7134.2014.12084.x
PG 14
WC Entomology
SC Entomology
GA AH3XJ
UT WOS:000336059300021
PM 24820570
ER
PT J
AU Zubko, E
Muinonen, K
Videen, G
Kiselev, NN
AF Zubko, Evgenij
Muinonen, Karri
Videen, Gorden
Kiselev, Nikolai N.
TI Dust in Comet C/1975 V1 (West)
SO MONTHLY NOTICES OF THE ROYAL ASTRONOMICAL SOCIETY
LA English
DT Article
DE polarization; scattering; methods: numerical; comets: individual: Comet
C/1975 V1 (West)
ID DISCRETE-DIPOLE APPROXIMATION; NARROW-BAND PHOTOMETRY; INFRARED
OBSERVATIONS; HALE-BOPP; 81P/WILD 2; POLARIMETRIC OBSERVATIONS; OPTICAL
POLARIMETRY; PHASE ANGLES; HALLEY DUST; SCATTERING
AB We analyse the photopolarimetric response measured in Comet C/1975 V1 (West) using model agglomerated debris particles. Such particles have highly irregular morphology and volume density with properties that are consistent with the samples retrieved by Stardust from Comet 81P/Wild 2. We find that an entire set of observational data including phase function, phase dependence of the degree of linear polarization, photometric, and polarimetric colour in Comet C/1975 V1 (West) can be quantitatively reproduced with a two-component mixture of weakly and highly absorbing particles, having refractive indices m = 1.5+0i or 1.6+0.0005i and 2.43+0.59i, respectively. These refractive indices are consistent with Mg-rich silicates and amorphous carbon, two species considered to be abundant in comets. Our modelling predicts the volume ratio of these materials being about 1:3. We note that in situ mass spectrometry measurements of Comet 1P/Halley suggested a similar ratio of weakly to highly absorbing particles, with a large uncertainty. The best fit to observations is obtained for a polydisperse ensembles of particles that obey the power-law size distribution r(-1.5) and r(-2). Such a distribution also is in good agreement with in situ studies of Comet 1P/Halley. While our modelling can reproduce the photopolarimetric properties of Comet C/1975 V1 (West), it also is one of the simplest approach, since it has fewer free parameters than other approaches.
C1 [Zubko, Evgenij] Kharkov Natl Univ, Inst Astron, UA-61022 Kharkov, Ukraine.
[Muinonen, Karri] Univ Helsinki, Dept Phys, FIN-00014 Helsinki, Finland.
[Muinonen, Karri] Finnish Geodet Inst, FI-02431 Masala, Finland.
[Videen, Gorden] Space Sci Inst, Boulder, CO 80301 USA.
[Videen, Gorden] US Army Res Lab, Adelphi, MD 20783 USA.
[Kiselev, Nikolai N.] Natl Acad Sci Ukraine, Main Astron Observ, UA-03680 Kiev, Ukraine.
RP Zubko, E (reprint author), Kharkov Natl Univ, Inst Astron, 35 Sumskaya St, UA-61022 Kharkov, Ukraine.
EM ezubko@rambler.ru
FU ERC [320773]; Academy of Finland [257966]; NASA [NNX10AP93G]
FX This work was partially supported by the ERC Advanced Grant No 320773
entitled 'Scattering and Absorption of Electromagneetic Waves in
Particulate Media' (SAEMPL), by the Academy of Finland (contract
257966), and by NASA program for Outer Planets Research (grant
NNX10AP93G). We are grateful to Professor A. Ch. Levasseur-Regourd for
valuable comments on this paper.
NR 69
TC 8
Z9 8
U1 0
U2 6
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0035-8711
EI 1365-2966
J9 MON NOT R ASTRON SOC
JI Mon. Not. Roy. Astron. Soc.
PD JUN
PY 2014
VL 440
IS 4
BP 2928
EP 2943
DI 10.1093/mnras/stu480
PG 16
WC Astronomy & Astrophysics
SC Astronomy & Astrophysics
GA AH6AT
UT WOS:000336213800004
ER
PT J
AU Corona, BT
Garg, K
Roe, JL
Zhu, H
Park, KH
Ma, JJ
Walters, TJ
AF Corona, Benjamin T.
Garg, Koyal
Roe, Janet L.
Zhu, Hua
Park, Ki Ho
Ma, Jianjie
Walters, Thomas J.
TI EFFECT OF RECOMBINANT HUMAN MG53 PROTEIN ON TOURNIQUET-INDUCED
ISCHEMIA-REPERFUSION INJURY IN RAT MUSCLE
SO MUSCLE & NERVE
LA English
DT Article
DE ischemia-reperfusion; MG53; muscle injury; tourniquet; TRIM72
ID MEMBRANE REPAIR; SKELETAL-MUSCLE; COMPARTMENT SYNDROME
AB Introduction: Skeletal muscle ischemia-reperfusion injury (I-R) is a complex injury process that includes damage to the sarcolemmal membrane, contributing to necrosis and apoptosis. MG53, a muscle-specific TRIM family protein, has been shown to be essential for regulating membrane repair and has been shown to be protective against cardiac I-R and various forms of skeletal muscle injury. The purpose of this study was to determine if recombinant human MG53 (rhMG53) administration offered protection against I-R. Methods: rhMG53 was administered to rats immediately before tourniquet-induced ischemia and again immediately before reperfusion. Two days later muscle damage was assessed histologically. Results: rhMG53 offered no protective effect, as evidenced primarily by similar Evans blue dye inclusion in the muscles of rats administered rhMG53 or saline. Conclusions: Administration of rhMG53 does not offer protection against I-R in rat skeletal muscle. Additional studies are required to determine if the lack of a response is species-specific. Muscle Nerve49: 919-921, 2014
C1 [Corona, Benjamin T.; Garg, Koyal; Roe, Janet L.; Walters, Thomas J.] US Army Inst Surg Res, Ft Sam Houston, TX 78234 USA.
[Zhu, Hua; Park, Ki Ho; Ma, Jianjie] Ohio State Univ, Wexner Med Ctr, Davis Heart & Lung Res Inst, Dept Surg, Columbus, OH 43210 USA.
RP Walters, TJ (reprint author), US Army Inst Surg Res, 3698 Chambers Pass, Ft Sam Houston, TX 78234 USA.
EM thomas.j.walters22.civ@mail.mil
RI Zhu, Hua/G-4409-2010
FU U.S. Army Medical Research and Medical Command [F_025_2010_USAISR];
National Institutes of Health
FX This work was funded by the U.S. Army Medical Research and Medical
Command (grant: F_025_2010_USAISR) awarded to T.J.W., and National
Institutes of Health grant awarded to J.M. All animal protocols were
approved by the U.S. Army Institute of Surgical Research Animal Care and
Use Committee. This study adhered to National Institutes of Health
guidelines for the care and use of laboratory animals (DHHS Publication,
NIH, 86 to 23). All components of this study including the decision
where to publish were at the sole discretion of the authors. The
opinions or assertions contained herein are the private views of the
authors and are not to be construed as official or reflecting the views
of the Department of Defense (AR 360-5) or the United States Government.
Some of the authors are employees of the U.S. government, and this work
was prepared as part of their official duties.
NR 16
TC 3
Z9 5
U1 1
U2 10
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0148-639X
EI 1097-4598
J9 MUSCLE NERVE
JI Muscle Nerve
PD JUN
PY 2014
VL 49
IS 6
BP 919
EP 921
DI 10.1002/mus.24160
PG 3
WC Clinical Neurology; Neurosciences
SC Neurosciences & Neurology
GA AH2MA
UT WOS:000335954400018
PM 24395153
ER
PT J
AU Prager, EM
Aroniadou-Anderjaska, V
Almeida-Suhett, CP
Figueiredo, TH
Apland, JP
Rossetti, F
Olsen, CH
Braga, MFM
AF Prager, Eric M.
Aroniadou-Anderjaska, Vassiliki
Almeida-Suhett, Camila P.
Figueiredo, Taiza H.
Apland, James P.
Rossetti, Franco
Olsen, Cara H.
Braga, Maria F. M.
TI The recovery of acetylcholinesterase activity and the progression of
neuropathological and pathophysiological alterations in the rat
basolateral amygdala after soman-induced status epilepticus: Relation to
anxiety-like behavior
SO NEUROPHARMACOLOGY
LA English
DT Article
DE Soman; Status epilepticus; Basolateral amygdala; Acetylcholinesterase;
Anxiety; Long-term potentiation
ID POSTTRAUMATIC-STRESS-DISORDER; RECEPTOR ANTAGONIST LY293558; INDUCED
SEIZURE ACTIVITY; INDUCED NEURONAL INJURY; LONG-TERM CONSEQUENCES;
AGENT-INDUCED SEIZURE; TOKYO SUBWAY ATTACK; NERVE AGENTS;
CHOLINE-ACETYLTRANSFERASE; ELECTRICAL-STIMULATION
AB Organophosphorus nerve agents are powerful neurotoxins that irreversibly inhibit acetylcholinesterase (AChE) activity. One of the consequences of AChE inhibition is the generation of seizures and status epilepticus (SE), which cause brain damage, resulting in long-term neurological and behavioral deficits. Increased anxiety is the most common behavioral abnormality after nerve agent exposure. This is not surprising considering that the amygdala, and the basolateral nucleus of the amygdala (BLA) in particular, plays a central role in anxiety, and this structure suffers severe damage by nerve agent-induced seizures. In the present study, we exposed male rats to the nerve agent soman, at a dose that induce SE, and determined the time course of recovery of AChE activity, along with the progression of neuropathological and pathophysiological alterations in the BLA, during a 30-day period after exposure. Measurements were taken at 24 h, 7 days, 14 days, and 30 days after exposure, and at 14 and 30 days, anxiety-like behavior was also evaluated. We found that more than 90% of AChE is inhibited at the onset of SE, and AChE inhibition remains at this level 24 h later, in the BLA, as well as in the hippocampus, piriform cortex, and prelimbic cortex, which we analyzed for comparison. AChE activity recovered by day 7 in the BLA and day 14 in the other three regions. Significant neuronal loss and neurodegeneration were present in the BLA at 24 h and throughout the 30-day period. There was no significant loss of GABAergic interneurons in the BLA at 24 h post-exposure. However, by day 7, the number of GABAergic interneurons in the BLA was reduced, and at 14 and 30 days after soman, the ratio of GABAergic interneurons to the total number of neurons was lower compared to controls. Anxiety-like behavior in the open-field and the acoustic startle response tests was increased at 14 and 30 days post-exposure. Accompanying pathophysiological alterations in the BLA studied in in vitro brain slices included a reduction in the amplitude of field potentials evoked by stimulation of the external capsule, along with prolongation of their time course and an increase in the paired-pulse ratio. Long-term potentiation was impaired at 24 h, 7 days, and 14 days post-exposure. The loss of GABAergic interneurons in the BLA and the decreased interneuron to total number of neurons ratio may be the primary cause of the development of anxiety after nerve agent exposure. Published by Elsevier Ltd.
C1 [Prager, Eric M.; Aroniadou-Anderjaska, Vassiliki; Almeida-Suhett, Camila P.; Figueiredo, Taiza H.; Rossetti, Franco; Braga, Maria F. M.] Uniformed Serv Univ Hlth Sci, F Edward Hebert Sch Med, Dept Anat Physiol & Genet, Bethesda, MD 20814 USA.
[Aroniadou-Anderjaska, Vassiliki; Braga, Maria F. M.] Uniformed Serv Univ Hlth Sci, F Edward Hebert Sch Med, Dept Psychiat, Bethesda, MD 20814 USA.
[Prager, Eric M.; Aroniadou-Anderjaska, Vassiliki; Almeida-Suhett, Camila P.; Braga, Maria F. M.] Uniformed Serv Univ Hlth Sci, F Edward Hebert Sch Med, Program Neurosci, Bethesda, MD 20814 USA.
[Olsen, Cara H.] Uniformed Serv Univ Hlth Sci, F Edward Hebert Sch Med, Biostat Consulting Ctr, Bethesda, MD 20814 USA.
[Apland, James P.] US Army, Med Res Inst Chem Def, Neurotoxicol Branch, Aberdeen Proving Ground, MD 21010 USA.
RP Braga, MFM (reprint author), Uniformed Serv Univ Hlth Sci, F Edward Hebert Sch Med, Dept Anat Physiol & Genet, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA.
EM maria.braga@usuhs.edu
RI Prager, Eric/O-1567-2015
OI Prager, Eric/0000-0002-3810-0985
FU CounterACT Program, National Institutes of Health, Office of the
Director and the National Institute of Neurologic Disorders and Stroke
[5U01NS05816207]; Defense Threat Reduction Agency-Joint Science and
Technology Office, Medical ST Division [CBM.NEURO.01.10.US.18,
CBM.NEURO.01.10.US.15]
FX This work was supported by the CounterACT Program, National Institutes
of Health, Office of the Director and the National Institute of
Neurologic Disorders and Stroke [Grant Number 5U01NS058162-07], and the
Defense Threat Reduction Agency-Joint Science and Technology Office,
Medical S&T Division [Grant Numbers CBM.NEURO.01.10.US.18 and
CBM.NEURO.01.10.US.15].
NR 97
TC 13
Z9 13
U1 0
U2 10
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0028-3908
EI 1873-7064
J9 NEUROPHARMACOLOGY
JI Neuropharmacology
PD JUN
PY 2014
VL 81
BP 64
EP 74
DI 10.1016/j.neuropharm.2014.01.035
PG 11
WC Neurosciences; Pharmacology & Pharmacy
SC Neurosciences & Neurology; Pharmacology & Pharmacy
GA AG7XP
UT WOS:000335632400007
PM 24486384
ER
PT J
AU Lawson, BK
Jenne, JW
Koebbe, CJ
AF Lawson, Bryan K.
Jenne, Joel W.
Koebbe, Christopher J.
TI Cauda equina and conus medullaris avulsion with herniation after
midlumbar chance fracture
SO SPINE JOURNAL
LA English
DT Editorial Material
C1 [Lawson, Bryan K.; Jenne, Joel W.] Brooke Army Med Ctr, Dept Orthopaed & Rehabil, JBSA Ft Sam, Houston, TX 78234 USA.
[Koebbe, Christopher J.] Brooke Army Med Ctr, Dept Neurol Surg, JBSA Ft Sam, Houston, TX 78234 USA.
RP Lawson, BK (reprint author), Brooke Army Med Ctr, Dept Orthopaed & Rehabil, JBSA Ft Sam, 3551 Roger Brooke Dr, Houston, TX 78234 USA.
NR 4
TC 1
Z9 1
U1 0
U2 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1529-9430
EI 1878-1632
J9 SPINE J
JI Spine Journal
PD JUN
PY 2014
VL 14
IS 6
BP 1060
EP 1062
DI 10.1016/j.spinee.2013.11.032
PG 3
WC Clinical Neurology; Orthopedics
SC Neurosciences & Neurology; Orthopedics
GA AH8UA
UT WOS:000336412500033
PM 24291702
ER
PT J
AU Shiflett, SA
Zinnert, JC
Young, DR
AF Shiflett, Sheri A.
Zinnert, Julie C.
Young, Donald R.
TI Conservation of functional traits leads to shrub expansion across a
chronosequence of shrub thicket development
SO TREES-STRUCTURE AND FUNCTION
LA English
DT Article
DE Chronosequence; Chlorophyll fluorescence; ETR; Hydraulic conductivity;
Shrub expansion
ID VIRGINIA BARRIER ISLANDS; MYRICA-CERIFERA; WATER-STRESS; CHLOROPHYLL
FLUORESCENCE; PHYSIOLOGICAL-RESPONSES; HYDRAULIC CONDUCTIVITY; STOMATAL
DENSITY; DROUGHT STRESS; FRESH-WATER; VEGETATION
AB Robust physiology of Myrica cerifera across a chronosequence (i.e., space for time substitution) of shrub thicket age classes contributes to rapid cover expansion observed in the last 50 years.
Many studies have documented the causes of woody expansion into grasslands, but few address unique morphological and physiological traits that facilitate expansion. Myrica cerifera, an evergreen N-fixer, is the dominant shrub on many barrier islands of the southeastern United States. Cover of Myrica cerifera has expanded by similar to 400 % on Hog Island, Virginia, in the past 50 years. Accretion of the northern end of the island has resulted in a chronosequence (i.e., space for time substitution) of both soil age and shrub thicket development. We investigated functional traits and physiological parameters related to light capture, processing and water balance of M. cerifera across shrub thickets of four age classes from similar to 10 to similar to 50 years. We hypothesized that light processing capabilities and hydraulic capacity would be reduced with thicket age. Spatial variation in morphology (i.e., leaf thickness, leaf area) and structure (i.e., leaf angle) related to light capture was observed. Yet, little or no differences were detected in stomatal density, photosynthetic pigments, electron transport rate (ETR) and hydraulic conductivity across sites. Previous research has shown declines in leaf N content, productivity and leaf litter production across the chronosequence. In contrast, we observed that physiology remains consistent despite considerable differences in thicket age and development. Myrica cerifera maintains high photosynthetic and hydraulic efficiency, factors which enable expansion and maintenance of shrub thickets in mesic coastal environments.
C1 [Shiflett, Sheri A.; Zinnert, Julie C.; Young, Donald R.] Virginia Commonwealth Univ, Dept Biol, Richmond, VA 23284 USA.
[Zinnert, Julie C.] US Army ERDC, Fluorescence Spect Lab, Alexandria, VA 22315 USA.
RP Young, DR (reprint author), Virginia Commonwealth Univ, Dept Biol, Richmond, VA 23284 USA.
EM dryoung@vcu.edu
RI Young, Kristina/M-3069-2014
FU NSF [DEB-0621014]
FX This study was supported in part by an NSF grant (DEB-0621014) to the
University of Virginia for LTER-related work at the Virginia Coast
Reserve. Andre Carapeto, Andrew McIntyre III and Paul Manley assisted
with field work. Aaron Lee, Audrey Kirschner, Cameron Ashgarpour, and
Jessica Daniels assisted with laboratory analysis. The authors thank the
VCR-LTER laboratory staff for accommodating logistical and temporal
sampling needs.
NR 60
TC 3
Z9 4
U1 1
U2 14
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0931-1890
EI 1432-2285
J9 TREES-STRUCT FUNCT
JI Trees-Struct. Funct.
PD JUN
PY 2014
VL 28
IS 3
BP 849
EP 858
DI 10.1007/s00468-014-0997-y
PG 10
WC Forestry
SC Forestry
GA AH6VQ
UT WOS:000336270400018
ER
PT J
AU Wang, ZL
Mourelatos, ZP
Li, J
Baseski, I
Singh, A
AF Wang, Zhonglai
Mourelatos, Zissimos P.
Li, Jing
Baseski, Igor
Singh, Amandeep
TI Time-Dependent Reliability of Dynamic Systems Using Subset Simulation
With Splitting Over a Series of Correlated Time Intervals
SO JOURNAL OF MECHANICAL DESIGN
LA English
DT Article
ID HYDROKINETIC TURBINE-BLADES; STOCHASTIC EXCITATION; COMPONENTS; SUBJECT;
DESIGN; MODELS
AB Time-dependent reliability is the probability that a system will perform its intended function successfully for a specified time. Unless many and often unrealistic assumptions are made, the accuracy and efficiency of time-dependent reliability estimation are major issues which may limit its practicality. Monte Carlo simulation (MCS) is accurate and easy to use, but it is computationally prohibitive for high dimensional, long duration, time-dependent (dynamic) systems with a low failure probability. This work is relevant to systems with random parameters excited by stochastic processes. Their response is calculated by time integrating a set of differential equations at discrete times. The limit state functions are, therefore, explicit in time and depend on time-invariant random variables and time-dependent stochastic processes. We present an improved subset simulation with splitting approach by partitioning the original high dimensional random process into a series of correlated, short duration, low dimensional random processes. Subset simulation reduces the computational cost by introducing appropriate intermediate failure sub-domains to express the low failure probability as a product of larger conditional failure probabilities. Splitting is an efficient sampling method to estimate the conditional probabilities. The proposed subset simulation with splitting not only estimates the time-dependent probability of failure at a given time but also estimates the cumulative distribution function up to that time with approximately the same cost. A vibration example involving a vehicle on a stochastic road demonstrates the advantages of the proposed approach.
C1 [Wang, Zhonglai] Univ Elect Sci & Technol China, Chengdu 611731, Sichuan, Peoples R China.
[Mourelatos, Zissimos P.; Li, Jing] Oakland Univ, Dept Mech Engn, Rochester, MI 48309 USA.
[Baseski, Igor; Singh, Amandeep] US Army TARDEC, Warren, MI 48397 USA.
RP Mourelatos, ZP (reprint author), Oakland Univ, Dept Mech Engn, Rochester, MI 48309 USA.
EM mourelat@oakland.edu
FU Automotive Research Center (ARC), U.S. Army Tank Automotive Research,
Development and Engineering Center (TARDEC) [W56HZV-04-2-0001]
FX We would like to acknowledge the technical and financial support of the
Automotive Research Center (ARC) in accordance with Cooperative
Agreement No. W56HZV-04-2-0001 U.S. Army Tank Automotive Research,
Development and Engineering Center (TARDEC).
NR 35
TC 7
Z9 7
U1 0
U2 13
PU ASME
PI NEW YORK
PA TWO PARK AVE, NEW YORK, NY 10016-5990 USA
SN 1050-0472
J9 J MECH DESIGN
JI J. Mech. Des.
PD JUN
PY 2014
VL 136
IS 6
AR 061008
DI 10.1115/1.4027162
PG 12
WC Engineering, Mechanical
SC Engineering
GA AH2LO
UT WOS:000335953200008
ER
PT J
AU Panchal, RG
Mourich, DV
Bradfute, S
Hauck, LL
Warfield, KL
Iversen, PL
Bavari, S
AF Panchal, Rekha G.
Mourich, Dan V.
Bradfute, Steven
Hauck, Laura L.
Warfield, Kelly L.
Iversen, Patrick L.
Bavari, Sina
TI Induced IL-10 Splice Altering Approach to Antiviral Drug Discovery
SO NUCLEIC ACID THERAPEUTICS
LA English
DT Article
ID EBOLA-VIRUS INFECTION; T-CELL RESPONSES; ANTISENSE OLIGOMERS;
INTERLEUKIN-10; PROTECTION; APOPTOSIS; CYTOKINE
AB Ebola virus causes an acute hemorrhagic fever lethal in primates and rodents. The contribution of host immune factors to pathogenesis has yet to be determined and may reveal efficacious targets for potential treatment. In this study, we show that the interleukin (IL)-10 signaling pathway modulates Ebola pathogenesis. IL-10(-/-) mice and wild-type mice receiving antisense targeting IL-10 signaling via disrupting expression through aberrant splice altering were resistant to ebola virus infection. IL-10(-/-) mice exhibited reduced viral titers, pathology, and levels of IL-2, IL-6, keratinocyte-derived chemokine (KC), and macrophage inflammatory protein-1 alpha and increased interferon (IFN)-gamma relative to infected wild-type mice. Furthermore, antibody depletion studies in IL-10(-/-) mice suggest a requirement for natural killer cells and IFN-gamma for protection. Together, these data demonstrate that resistance to ebola infection is regulated by IL-10 and can be targeted in a prophylactic manner to protect against lethal hemorrhagic virus challenge.
C1 [Panchal, Rekha G.; Bradfute, Steven; Warfield, Kelly L.; Bavari, Sina] US Army Med Res Inst Infect Dis, Ft Detrick, MD USA.
[Mourich, Dan V.; Hauck, Laura L.; Iversen, Patrick L.] Sarepta Therapeut Inc, Corvallis, OR USA.
[Mourich, Dan V.; Hauck, Laura L.; Iversen, Patrick L.] Oregon State Univ, Corvallis, OR 97331 USA.
RP Mourich, DV (reprint author), Sarepta Therapeut, 4575 Southwest Res Way,Suite 200, Corvallis, OR 97333 USA.
EM Dmourich@Sarepta.com
FU Postgraduate Research Participation Program at the U.S. Army Medical
Research Institute of Infectious Diseases (USAMRID); U.S. Department of
Energy; U.S. Army Medical Research and Materiel Command (USAMRMC); Joint
Project Manager-Transformational Medical Technologies Initiative
[HDTRA1-07-C-0010]
FX Support from Postgraduate Research Participation Program at the U.S.
Army Medical Research Institute of Infectious Diseases (USAMRID)
administered by the Oak Ridge Institute for Science and Education and
the U.S. Department of Energy and the U.S. Army Medical Research and
Materiel Command (USAMRMC). We thank Jay Wells, Sean Van Tongeren, Kelly
Donner, Christine Mech, Jeff Brubaker, and Shannon Oda for expert
technical assistance. This work was supported by multiple contracts to
Sarepta Therapeutics, Inc. by the Joint Project Manager-Transformational
Medical Technologies Initiative (HDTRA1-07-C-0010). Opinions,
interpretations, conclusions, and recommendations are those of the
authors and are not necessarily endorsed by the U.S. Army.
NR 19
TC 4
Z9 5
U1 0
U2 22
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 2159-3337
EI 2159-3345
J9 NUCLEIC ACID THER
JI Nucl. Acid Ther.
PD JUN 1
PY 2014
VL 24
IS 3
BP 179
EP 185
DI 10.1089/nat.2013.0457
PG 7
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Medicine,
Research & Experimental
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Research &
Experimental Medicine
GA AH2OJ
UT WOS:000335960500001
PM 24655055
ER
PT J
AU Little, DM
Geary, EK
Moynihan, M
Alexander, A
Pennington, M
Glang, P
Schulze, ET
Dretsch, M
Pacifico, A
Davis, ML
Stevens, AB
Huang, JH
AF Little, Deborah M.
Geary, Elizabeth K.
Moynihan, Michael
Alexander, Aristides
Pennington, Michelle
Glang, Patrick
Schulze, Evan T.
Dretsch, Michael
Pacifico, Anthony
Davis, Matthew L.
Stevens, Alan B.
Huang, Jason H.
TI Imaging chronic traumatic brain injury as a risk factor for
neurodegeneration
SO ALZHEIMERS & DEMENTIA
LA English
DT Article
DE Traumatic brain injury; Repetitive TBI; Dementia; Neuroimaging
ID MINI-MENTAL-STATE; INTEGRITY
AB Population-based studies have supported the hypothesis that a positive history of traumatic brain injury (TBI) is associated with an increased incidence of neurological disease and psychiatric comorbidities, including chronic traumatic encephalopathy, Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis. These epidemiologic studies, however, do not offer a clear definition of that risk, and leave unanswered the bounding criteria for greater lifetime risk of neurodegeneration. Key factors that likely mediate the degree of risk of neurodegeneration include genetic factors, significant premorbid and comorbid medical history (e.g. depression, multiple head injuries and repetitive subconcussive impact to the brain, occupational risk, age at injury, and severity of brain injury). However, given the often-described concerns in self-report accuracy as it relates to history of multiple TBIs, low frequency of patient presentation to a physician in the case of mild brain injuries, and challenges with creating clear distinctions between injury severities, disentangling the true risk for neurodegeneration based solely on population-based studies will likely remain elusive. Given this reality, multiple modalities and approaches must be combined to characterize who are at risk so that appropriate interventions to alter progression of neurodegeneration can be evaluated. This article presents data from a study that highlights uses of neuro-imaging and areas of needed research in the link between TBI and neurodegenerative disease. (C) 2014 Published by Elsevier Inc. on behalf of The Alzheimer's Association.
C1 [Little, Deborah M.; Pennington, Michelle; Davis, Matthew L.; Stevens, Alan B.; Huang, Jason H.] BaylorScott & White Hlth, Temple, TX 75201 USA.
[Little, Deborah M.; Davis, Matthew L.; Stevens, Alan B.; Huang, Jason H.] Texas A&M Univ Hlth Sci, Temple, TX USA.
[Geary, Elizabeth K.] Northshore Hlth Syst, Evanston, IL USA.
[Moynihan, Michael] West Virginia Sch Osteopath Med, Lewisburg, WV USA.
[Alexander, Aristides] Advocate Christ Med Ctr, Chicago, IL USA.
[Glang, Patrick] Univ Oregon, Eugene, OR 97403 USA.
[Schulze, Evan T.] St Louis Univ, St Louis, MO 63103 USA.
[Dretsch, Michael] Walter Reed Natl Mil Med Ctr, Natl Intrepid Ctr Excellence, Bethesda, MD USA.
[Pacifico, Anthony] US Army Med Res & Mat Command, Telemed & Adv Technol Res Ctr, Ft Detrick, MD USA.
RP Little, DM (reprint author), BaylorScott & White Hlth, Temple, TX 75201 USA.
EM deborahmlittle@gmail.com
FU Department of Defense/Congressionally Directed Medical Research Program
[PT 075675]; Marshall Goldberg Traumatic Brain Injury Fund; Chicago
Institute for Neurosurgery and Neuroresearch Foundation
FX This work is supported in part by a Department of
Defense/Congressionally Directed Medical Research Program grant (PT
075675 to DML), the Marshall Goldberg Traumatic Brain Injury Fund (to
DML), and a grant from the Chicago Institute for Neurosurgery and
Neuroresearch Foundation (to DML). The contents of this article are the
sole responsibility of the authors and do not necessarily represent the
official views of the University of Illinois at Chicago, Baylor Scott &
White Health, Texas A&M University Health Sciences, the U.S. Department
of the Army, the Department of Defense, or the National Institutes of
Health.
NR 25
TC 5
Z9 6
U1 1
U2 9
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1552-5260
EI 1552-5279
J9 ALZHEIMERS DEMENT
JI Alzheimers. Dement.
PD JUN
PY 2014
VL 10
IS 3
SU 1
BP S188
EP S195
DI 10.1016/j.jalz.2014.04.002
PG 8
WC Clinical Neurology
SC Neurosciences & Neurology
GA CP8GM
UT WOS:000360130700013
PM 24924670
ER
PT J
AU Weiner, MW
Veitch, DP
Hayes, J
Neylan, T
Grafman, J
Aisen, PS
Petersen, RC
Jack, C
Jagust, W
Trojanowski, JQ
Shaw, LM
Saykin, AJ
Green, RC
Harvey, D
Toga, AW
Friedl, KE
Pacifico, A
Sheline, Y
Yaffe, K
Mohlenoff, B
AF Weiner, Michael W.
Veitch, Dallas P.
Hayes, Jacqueline
Neylan, Thomas
Grafman, Jordan
Aisen, Paul S.
Petersen, Ronald C.
Jack, Clifford
Jagust, William
Trojanowski, John Q.
Shaw, Leslie M.
Saykin, Andrew J.
Green, Robert C.
Harvey, Danielle
Toga, Arthur W.
Friedl, Karl E.
Pacifico, Anthony
Sheline, Yvette
Yaffe, Kristine
Mohlenoff, Brian
CA Dept Def Alzheimer's Dis
TI Effects of traumatic brain injury and posttraumatic stress disorder on
Alzheimer's disease in veterans, using the Alzheimer's Disease
Neuroimaging Initiative
SO ALZHEIMERS & DEMENTIA
LA English
DT Article
DE Traumatic brain injury; Posttraumatic stress disorder; Alzheimer's
disease; Veterans; Neuroimaging
ID AMYLOID PROTEIN DEPOSITION; MILD COGNITIVE IMPAIRMENT; ADDICTION
SEVERITY INDEX; HEAD-INJURY; APOLIPOPROTEIN-E; CEREBROSPINAL-FLUID;
BIOMARKER SIGNATURE; N-ACETYLASPARTATE; FLORBETAPIR F-18; TERM SURVIVORS
AB Both traumatic brain injury (TBI) and posttraumatic stress disorder (PTSD) are common problems resulting from military service, and both have been associated with increased risk of cognitive decline and dementia resulting from Alzheimer's disease (AD) or other causes. This study aims to use imaging techniques and biomarker analysis to determine whether traumatic brain injury (TBI) and/or PTSD resulting from combat or other traumas increase the risk for AD and decrease cognitive reserve in Veteran subjects, after accounting for age. Using military and Department of Veterans Affairs records, 65 Vietnam War veterans with a history of moderate or severe TBI with or without PTSD, 65 with ongoing PTSD without TBI, and 65 control subjects are being enrolled in this study at 19 sites. The study aims to select subject groups that are comparable in age, gender, ethnicity, and education. Subjects with mild cognitive impairment (MCI) or dementia are being excluded. However, a new study just beginning, and similar in size, will study subjects with TBI, subjects with PTSD, and control subjects with MCI. Baseline measurements of cognition, function, blood, and cerebrospinal fluid biomarkers; magnetic resonance images (structural, diffusion tensor, and resting state blood-level oxygen dependent (BOLD) functional magnetic resonance imaging); and amyloid positron emission tomographic (PET) images with florbetapir are being obtained. One-year follow-up measurements will be collected for most of the baseline procedures, with the exception of the lumbar puncture, the PET imaging, and apolipoprotein E genotyping. To date, 19 subjects with TBI only, 46 with PTSD only, and 15 with TBI and PTSD have been recruited and referred to 13 clinics to undergo the study protocol. It is expected that cohorts will be fully recruited by October 2014. This study is a first step toward the design and statistical powering of an AD prevention trial using at-risk veterans as subjects, and provides the basis for a larger, more comprehensive study of dementia risk factors in veterans. (C) 2014 Published by Elsevier Inc. on behalf of The Alzheimer's Association.
C1 [Weiner, Michael W.; Veitch, Dallas P.; Hayes, Jacqueline] Ctr Imaging Neurodegenerat Dis, Dept Vet Affairs Med Ctr, San Francisco, CA 94143 USA.
[Weiner, Michael W.] Univ Calif San Francisco, Dept Radiol, San Francisco, CA USA.
[Weiner, Michael W.] Univ Calif San Francisco, Dept Med, San Francisco, CA USA.
[Weiner, Michael W.; Neylan, Thomas; Yaffe, Kristine; Mohlenoff, Brian] Univ Calif San Francisco, Dept Psychiat, San Francisco, CA USA.
[Weiner, Michael W.; Yaffe, Kristine] Univ Calif San Francisco, Dept Neurol, San Francisco, CA USA.
[Grafman, Jordan] Northwestern Univ, Feinberg Sch Med, Dept Psychiat, Chicago, IL 60611 USA.
[Aisen, Paul S.] Univ Calif San Diego, Dept Neurosci, La Jolla, CA 92093 USA.
[Petersen, Ronald C.] Mayo Clin, Dept Neurol, Rochester, MN USA.
[Jack, Clifford] Mayo Clin, Dept Radiol, Rochester, MN USA.
[Jagust, William] Univ Calif Berkeley, Helen Wills Neurosci Inst, Berkeley, CA 94720 USA.
[Trojanowski, John Q.] Univ Penn, Perelman Sch Med, Inst Aging, Philadelphia, PA 19104 USA.
[Trojanowski, John Q.] Univ Penn, Perelman Sch Med, Alzheimers Dis Core Ctr, Philadelphia, PA 19104 USA.
[Trojanowski, John Q.] Univ Penn, Perelman Sch Med, Udall Parkinsons Res Ctr, Philadelphia, PA 19104 USA.
[Trojanowski, John Q.] Univ Penn, Perelman Sch Med, Ctr Neurodegenerat Res, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA.
[Shaw, Leslie M.] Univ Penn, Perelman Sch Med, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA.
[Saykin, Andrew J.] Indiana Univ, Sch Med, Dept Radiol & Imaging Sci, Indianapolis, IN USA.
[Saykin, Andrew J.] Indiana Univ, Sch Med, Dept Med & Mol Genet, Indianapolis, IN 46202 USA.
[Green, Robert C.] Brigham & Womens Hosp, Dept Med, Div Genet, Boston, MA 02115 USA.
[Green, Robert C.] Harvard Univ, Sch Med, Boston, MA USA.
[Harvey, Danielle] Univ Calif Davis, Dept Publ Hlth Sci, Div Biostat, Davis, CA 95616 USA.
[Toga, Arthur W.] Univ So Calif, Inst Neuroimaging & Informat, Lab Neuroimaging, Los Angeles, CA USA.
[Pacifico, Anthony] US Army Med Res & Mat Command, Telemed & Adv Technol Res Ctr, Ft Detrick, MD USA.
[Sheline, Yvette] Washington Univ, Sch Med, Dept Psychiat, St Louis, MO 63110 USA.
RP Weiner, MW (reprint author), Ctr Imaging Neurodegenerat Dis, Dept Vet Affairs Med Ctr, San Francisco, CA 94143 USA.
EM michael.weiner@ucsf.edu
RI Jack, Clifford/F-2508-2010
OI Jack, Clifford/0000-0001-7916-622X
FU National Institute on Aging; National Institute of Biomedical Imaging
and Bioengineering; Canadian Institutes of Health Research; DOD
[W81XWH-12-2-0012]
FX ADNI is funded by the National Institute on Aging and National Institute
of Biomedical Imaging and Bioengineering, and through generous
contributions from the following: Alzheimer's Association; Alzheimer's
Drug Discovery Foundation; Avid Radiopharmaceuticals, Inc; BioClinica,
Inc.; Biogen Idec Inc.; Bristol-Myers Squibb Company; Eisai Inc.; Elan
Pharmaceuticals, Inc.; Eli Lilly and Company; F. Hoffmann-La Roche Ltd
and its affiliated company Genentech, Inc.; GE Healthcare; Innogenetics,
N.V.; IXICO Ltd.; Janssen Alzheimer Immunotherapy Research &
Development, LLC; Johnson & Johnson Pharmaceutical Research &
Development LLC; Medpace, Inc.; Merck & Co., Inc.; Meso Scale
Diagnostics, LLC.; NeuroRx Research; Novartis Pharmaceuticals
Corporation; Pfizer Inc.; Piramal Imaging; Servier; Synarc Inc.; and
Takeda Pharmaceutical Company. The Canadian Institutes of Health
Research is providing funds to support ADNI clinical sites in Canada.
Private-sector contributions are facilitated by the Foundation for the
National Institutes of Health (www.fnih.org). The grantee organization
for ADNI is the Northern California Institute for Research and
Education, and the study is coordinated by the Alzheimer's Disease
Cooperative Study at the University of California, San Diego. ADNI DOD
data are disseminated by the Laboratory for Neuro Imaging at the
University of California, Los Angeles. We thank all the veterans for
their generous participation in this ADNI DOD study. This research was
also supported by DOD award number W81XWH-12-2-0012.
NR 114
TC 12
Z9 12
U1 4
U2 13
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1552-5260
EI 1552-5279
J9 ALZHEIMERS DEMENT
JI Alzheimers. Dement.
PD JUN
PY 2014
VL 10
IS 3
SU 1
BP S226
EP S235
DI 10.1016/j.jalz.2014.04.005
PG 10
WC Clinical Neurology
SC Neurosciences & Neurology
GA CP8GM
UT WOS:000360130700016
PM 24924673
ER
PT J
AU Matheny, RW
AF Matheny, Ronald Wayne
TI Skeletal Muscle-Specific Deletion of p110beta Reduces Skeletal Muscle
Mass and Strength in Mice
SO ENDOCRINE REVIEWS
LA English
DT Meeting Abstract
C1 [Matheny, Ronald Wayne] US Army, Environm Med Res Inst, Natick, MA 01760 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU ENDOCRINE SOC
PI WASHINGTON
PA 2055 L ST NW, SUITE 600, WASHINGTON, DC 20036 USA
SN 0163-769X
EI 1945-7189
J9 ENDOCR REV
JI Endocr. Rev.
PD JUN
PY 2014
VL 35
IS 3
SU S
MA MON-0345
PG 2
WC Endocrinology & Metabolism
SC Endocrinology & Metabolism
GA V45GM
UT WOS:000209805100252
ER
PT J
AU Riddle, MA
Leandry, LA
Matheny, RW
AF Riddle, Melissa A.
Leandry, Luis Angel
Matheny, Ronald Wayne
TI Pharmacological Inhibition of PI3K p110beta Suppresses Myoblast
Differentiation
SO ENDOCRINE REVIEWS
LA English
DT Meeting Abstract
C1 [Riddle, Melissa A.; Leandry, Luis Angel; Matheny, Ronald Wayne] US Army, Environm Med Res Inst, Natick, MA 01760 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU ENDOCRINE SOC
PI WASHINGTON
PA 2055 L ST NW, SUITE 600, WASHINGTON, DC 20036 USA
SN 0163-769X
EI 1945-7189
J9 ENDOCR REV
JI Endocr. Rev.
PD JUN
PY 2014
VL 35
IS 3
SU S
MA SUN-0361
PG 2
WC Endocrinology & Metabolism
SC Endocrinology & Metabolism
GA V45GM
UT WOS:000209805100250
ER
PT J
AU Truong, Q
Pomerantz, N
Yip, P
Sieber, M
Mabry, JM
Ramirez, SM
AF Quoc Truong
Pomerantz, Natalie
Yip, Pearl
Sieber, Michael
Mabry, Joseph M.
Ramirez, Sean M.
TI Pilot-scale coating of fabrics with fluorodecyl polyhedral oligomeric
silsesquioxane/fluoroelastomer blends
SO SURFACE INNOVATIONS
LA English
DT Article
DE coating; contact angle; oleophobic; self-cleaning; superhydrophobic;
surface energy
ID INTERFACIAL ENERGIES; SURFACES
AB A durable, conformal coating was developed based on the use of very low surface tension fluorodecyl polyhedral oligomeric silsesquioxane (Fluoro-POSS) cage-like molecule and a fluorinated elastomer. When this coating is applied, the resulting oleophobic fabrics resist surface wetting by a wide range of liquids having high to very low surface tension values, while remaining durable after repeated washing and abrasion testing. Collected data indicated minimal interference to air flow and moisture vapor through the conformally coated textiles. While textiles having said repellent treatment have been prepared previously by dip and spray coating in non-continuous laboratory applications, in 2012 the US Army Natick Research Development and Engineering Center successfully demonstrated a continuous, scalable application of Fluoro-POSS-treated textiles by way of a 24-inch-wide pad/dry/cure treatment. Material syntheses will be reported, and coating solution preparation and pilot-scale coating parameters will be discussed. Comparative data on surface, chemical and physical properties of lab-scale against pilot-scale coated repellent treated fabrics will be presented. These will include measurement of oleophobic coated fabrics' contact angle using various liquids such as water and hazardous chemicals, as well as evaluation of chemical permeation test results and physical properties. Future work will examine the effects of different concentrations of low surface tension fluoropolymers and elastomers, hierarchical re-entrant nanostructures, and optimal processing and curing conditions.
C1 [Quoc Truong] US Army, Dept Plast Engn, NSRDEC, Natick, MA 01760 USA.
[Quoc Truong] US Army, Dept Engn Management, NSRDEC, Natick, MA 01760 USA.
[Pomerantz, Natalie] US Army, Dept Chem Engn, NSRDEC, Natick, MA 01760 USA.
[Yip, Pearl] US Army, Dept Chem, NSRDEC, Natick, MA 01760 USA.
[Sieber, Michael] Oak Ridge Inst Sci & Educ, Dept Text Engn, Oak Ridge, TN USA.
[Mabry, Joseph M.] Air Force Res Lab, Aerosp Syst Directorate, Dept Polymer Chem, Edwards AFB, CA USA.
[Ramirez, Sean M.] Air Force Res Lab, ERC Inc, Dept Polymer Chem, Edwards AFB, CA USA.
RP Truong, Q (reprint author), US Army, Dept Plast Engn, NSRDEC, Natick, MA 01760 USA.
EM quoc.t.truong.civ@mail.mil
FU US Defense Threat Reduction Agency; Joint Science & Technology Office
for Chemical and Biological Defense as part of the Integrated Protective
Fabric Systems program [W911NF07D0004]; US Department of Energy; NSRDEC
FX This work was funded by the US Defense Threat Reduction Agency and Joint
Science & Technology Office for Chemical and Biological Defense as part
of the Integrated Protective Fabric Systems program (via ARO Contract
with ISN, contract W911NF07D0004). This work was supported in part by an
appointment to the Postgraduate Research Participant Program
administered by the Oak Ridge Institute for Science and Education's
Research Participant Program through an interagency agreement between
the US Department of Energy and NSRDEC. All textile testing were
conducted by NSRDEC Textile Materials Testing Laboratory. Special thanks
go to Drs Robert Cohen and Gareth McKinley from MIT, who provided
treated samples and insight related to developing superoleophobic
surfaces to the NSRDEC team; Mr Bill DiIanni and Mr Dale Arnold from
International Textile Group/Burlington Laboratory, who provided the ITG
nylon fabric Style 1194, which was used in this pilot scale up coating
study, other ITG nylon and polyester fabrics, and their insights related
to their fabric properties.
NR 19
TC 2
Z9 2
U1 2
U2 6
PU ICE PUBLISHING
PI WESTMINISTER
PA INST CIVIL ENGINEERS, 1 GREAT GEORGE ST, WESTMINISTER SW 1P 3AA, ENGLAND
SN 2050-6252
EI 2050-6260
J9 SURF INNOV
JI Surf. Innov.
PD JUN
PY 2014
VL 2
IS 2
BP 79
EP 93
DI 10.1680/si.13.00049
PG 15
WC Chemistry, Physical; Materials Science, Coatings & Films
SC Chemistry; Materials Science
GA CZ3AT
UT WOS:000366977100003
ER
PT J
AU Casem, DT
Dwivedi, AK
Mrozek, RA
Lenhart, JL
AF Casem, Daniel T.
Dwivedi, Ajmer K.
Mrozek, Randy A.
Lenhart, Joseph L.
TI Compression response of a thermoplastic elastomer gel tissue surrogate
over a range of strain-rates
SO INTERNATIONAL JOURNAL OF SOLIDS AND STRUCTURES
LA English
DT Article
DE Kolsky bar; Split Hopkinson pressure bar; High-rate testing; Ballistic
gelatin
ID HOPKINSON PRESSURE BAR; DEFORMATION; BEHAVIOR; INERTIA; COPPER
AB The mechanical response of a thermoplastic elastomer synthetic ballistic gel is studied over a range of strain-rates. Experiments were conducted at room temperature under uniaxial stress compression at rates ranging from 0.001 to 500/s. Low-rate experiments (< 1/s) were conducted with a servo-hydraulic load frame. High-rate experiments (> 100/s) were conducted with a polymeric Kolsky bar, along with several modifications to improve data quality. These modifications include the use of a commercial force transducer, a normal displacement interferometer, and a line laser extensometer. Because of the low shear strength and comparatively high compressibility of these materials, inertial effects are very pronounced. Specimen size is varied in an effort to study inertial effects at various loading rates. High speed photography is also used to demonstrate the presence of non-uniform deformation, due to both inertia and friction between the specimen and the loading surfaces. Finally, numerical simulation is used to verify trends observed in the experiments and further validate the data. It is concluded that this material is rate sensitive, with an almost three-fold increase in stiffness over the range of strain-rates studied. Published by Elsevier Ltd.
C1 [Casem, Daniel T.] US Army, Res Lab, RDRL WMP C, Aberdeen Proving Ground, MD 21005 USA.
[Dwivedi, Ajmer K.] Dynamic Sci Inc, RDRL WMP B, Aberdeen Proving Ground, MD 21005 USA.
[Mrozek, Randy A.; Lenhart, Joseph L.] US Army, Res Lab, RDRL WMM G, Aberdeen Proving Ground, MD 21005 USA.
RP Casem, DT (reprint author), US Army, Res Lab, RDRL WMP C, Aberdeen Proving Ground, MD 21005 USA.
EM daniel.t.casem.civ@mail.mil
NR 34
TC 1
Z9 1
U1 1
U2 29
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0020-7683
EI 1879-2146
J9 INT J SOLIDS STRUCT
JI Int. J. Solids Struct.
PD JUN 1
PY 2014
VL 51
IS 11-12
BP 2037
EP 2046
DI 10.1016/j.ijsolstr.2013.12.028
PG 10
WC Mechanics
SC Mechanics
GA AG2UH
UT WOS:000335272100001
ER
PT J
AU Bays, H
Cohen, DE
Chalasani, N
Harrison, SA
AF Bays, Harold
Cohen, David E.
Chalasani, Naga
Harrison, Stephen A.
TI An assessment by the Statin Liver Safety Task Force: 2014 update
SO JOURNAL OF CLINICAL LIPIDOLOGY
LA English
DT Article
DE Cholesterol; National Lipid; Association; Lipid; Liver; Statin
ID NONALCOHOLIC STEATOHEPATITIS; CARDIOVASCULAR EVENTS; DISEASE;
DYSLIPIDEMIA; ATORVASTATIN; CONSENSUS; INJURY; TRIAL
AB In the 2006 Report of the National Lipid Association's Statin Safety Task Force, a panel of experts in hepatology published their findings on specific questions related to the liver blood testing during statin therapy. Among their recommendations was that regulatory agencies reconsider the statin-labeling recommendation at that time, which required post-statin liver enzyme testing. Since then, the Food and Drug Administration altered statin labeling such that unless clinically indicated for other reasons, after a pre-statin therapy baseline evaluation, follow-up liver enzyme testing was not uniformly required after statin initiation. This 2014 report provides an update on interim issues relevant to statins and liver safety. Some of the points discussed include the value of baseline liver enzymes before initiating statin therapy, safety of statin use in patients with nonalcoholic fatty liver disease, potential drug interactions between statins and drugs used to treat hepatitis, the use of statins in liver transplant recipients, and the use of statins in patients with autoimmune liver disease. Finally, this panel provides diagnostic and algorithmic approaches when evaluating statin-treated patients who experience elevations in liver enzymes. (C) 2014 National Lipid Association. All rights reserved.
C1 [Bays, Harold] Louisville Metab & Atherosclerosis Res Ctr, Louisville, KY 40213 USA.
[Cohen, David E.] Harvard Univ, Brigham & Womens Hosp, Sch Med, Boston, MA 02115 USA.
[Chalasani, Naga] Indiana Univ Sch Med, Indianapolis, IN 46202 USA.
[Harrison, Stephen A.] Uniformed Serv Univ Hlth Sci, Univ Texas Hlth Ctr San Antonio, Brooke Army Med Ctr, San Antonio, TX USA.
RP Bays, H (reprint author), Louisville Metab & Atherosclerosis Res Ctr, 3288 Illinois Ave, Louisville, KY 40213 USA.
EM hbaysmd@aol.com
FU Alere; Amarin; Amgen; Ardea; Astra Zeneca; Boehringer Ingelheim;
Bristol-Myers Squibb; California Raisin Board; Catabasis; Eisai;
Elcelyx; Eli Lilly; Esperion; High Point Pharmaceuticals LLC;
Micropharma Limited
FX In the past 12 months, Dr. Harold Bays has served as a consultant and/or
speaker to Amarin, Amgen, Astra Zeneca, Bristol Meyers Squibb,
Catabasis, Daiichi Sankyo, Eisai, Isis, Merck, Novartis, VIVUS, WPU, and
his research site has received research grants from Alere, Amarin,
Amgen, Ardea, Astra Zeneca, Boehringer Ingelheim, Bristol-Myers Squibb,
California Raisin Board, Catabasis, Eisai, Elcelyx, Eli Lilly, Esperion,
Essentialis, Forest, Gilead, Given, GlaxoSmithKline, High Point
Pharmaceuticals LLC, Hoffman LaRoche, Home Access, Janssen, Merck,
Metabolex, Micropharma Limited, Necktar, Novartis, Novo Nordisk,
Omthera, Orexigen, Pfizer, Pronova, Regeneron, Stratum Nutrition,
Takeda, TIMI, Transtech Pharma, Trygg, VIVUS, WPU, and Xoma. Dr. David
Cohen reports having received consulting fees from Merck, Aegerion,
Dignity Sciences, Genzyme, and Novartis, and has additionally received
honoraria from Merck. Dr. Naga Chalasani reports serving as a consultant
to Aegerion, Salix, and Lilly; is on the Data and Safety Monitoring
Boards of AbbVie and Merck; and his institution has received research
grants from Gilead, Intercept, Cumberland, and Enterome. Dr. Stephen
Harrison discloses he has received consulting fees/honoraria from Merck,
Vertex, and the Chronic Liver Disease Foundation; consulting fees from
Nimbus and Genentech; and honoraria from the American Association for
Study of Liver Diseases.
NR 24
TC 44
Z9 50
U1 2
U2 10
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1933-2874
EI 1876-4789
J9 J CLIN LIPIDOL
JI J. Clin. Lipidol.
PD JUN
PY 2014
VL 8
IS 3
SU S
BP S47
EP S57
DI 10.1016/j.jacl.2014.02.011
PG 11
WC Pharmacology & Pharmacy
SC Pharmacology & Pharmacy
GA AG2YZ
UT WOS:000335284300005
PM 24793441
ER
PT J
AU Petrie, JR
Wieland, KA
Burke, RA
Newburgh, GA
Burnette, JE
Fischer, GA
Edelstein, AS
AF Petrie, J. R.
Wieland, K. A.
Burke, R. A.
Newburgh, G. A.
Burnette, J. E.
Fischer, G. A.
Edelstein, A. S.
TI A non-erasable magnetic memory based on the magnetic permeability
SO JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS
LA English
DT Article
DE Magnetic; Memory; Permeability; Non-erasable; Thermal
ID INTERFERENCE
AB A non-erasable memory based on using differences in the magnetic permeability is demonstrated. The method can potentially store information indefinitely. Initially the high permeability bits were 10-50 mu m wide lines of sputtered permalloy (Ni81Fe19) on a glass substrate. In a second writing technique a continuous film of amorphous, high permeability ferromagnetic Metglas (Fe78Si13B9) was sputtered onto a similar glass substrate. Low permeability, crystalline 50 mu m wide lines were then written in the film by laser heating. Both types of written media were read by applying an external probe field that is locally modified by the permeability of each bit. The modifications in the probe field were read by a nearby set of 10 micron wide magnetic tunnel junctions with a signal-to-noise ratio of up to 45 dB. This large response to changes in bit permeability is not altered after the media has been exposed to a 6400 Oe field. While being immediately applicable for data archiving and secure information storage, higher densities are possible with smaller read and write heads. Published by Elsevier B.V.
C1 [Petrie, J. R.; Wieland, K. A.; Burke, R. A.; Newburgh, G. A.; Fischer, G. A.; Edelstein, A. S.] US Army Res Lab, Adelphi, MD 20783 USA.
[Burnette, J. E.] Spin Transfer Technol, Boston, MA USA.
RP Edelstein, AS (reprint author), US Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA.
EM alan.s.edelstein.civ@us.army.mil
NR 27
TC 3
Z9 3
U1 1
U2 32
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0304-8853
EI 1873-4766
J9 J MAGN MAGN MATER
JI J. Magn. Magn. Mater.
PD JUN
PY 2014
VL 361
BP 262
EP 266
DI 10.1016/j.jmmm.2014.01.018
PG 5
WC Materials Science, Multidisciplinary; Physics, Condensed Matter
SC Materials Science; Physics
GA AE9OB
UT WOS:000334336000043
ER
PT J
AU Fullerton, RJ
Cole, DP
Behler, KD
Das, S
Irin, F
Parviz, D
Hoque, MNF
Fan, ZY
Green, MJ
AF Fullerton, Robert J.
Cole, Daniel P.
Behler, Kristopher D.
Das, Sriya
Irin, Fahmida
Parviz, Dorsa
Hoque, M. N. F.
Fan, Zhaoyang
Green, Micah J.
TI Graphene non-covalently tethered with magnetic nanoparticles
SO CARBON
LA English
DT Article
ID CARBON NANOTUBES; OXIDE; COMPOSITES
AB We describe a novel approach for coupling pristine graphene with superparamagnetic iron oxide nanoparticles to create dispersed, magnetically responsive hybrids. The magnetic iron oxide (Fe3O4) nanoparticles are synthesized by a co-precipitation method using ferric (Fe3+) and ferrous (Fe2+) salts and then grafted with polyvinylpyrrolidone (PVP). These PVP-grafted Fe3O4 nanoparticles are then used to stabilize colloidal graphene in water. The PVP branches non-covalently attach to the surface of the pristine graphene sheets without functionalization or defect creation. These Fe3O4-graphene hybrids are stable against aggregation and are highly responsive to external magnetic fields. These hybrids can be freeze-dried to a powder or magnetically separated from solution and still easily redisperse while retaining magnetic functionality. At all stages of synthesis, the Fe3O4-graphene hybrids display no coercivity after being brought to magnetic saturation, confirming superparamagnetic properties. Microscopy and light scattering data confirm the presence of pristine graphene sheets decorated with Fe3O4 nanoparticles. These materials show promise for multifunctional polymer composites as well as biomedical applications and environmental remediation. (C) 2014 Elsevier Ltd. All rights reserved.
C1 [Fullerton, Robert J.; Das, Sriya; Irin, Fahmida; Parviz, Dorsa; Green, Micah J.] Texas Tech Univ, Dept Chem Engn, Lubbock, TX 79409 USA.
[Hoque, M. N. F.; Fan, Zhaoyang] Texas Tech Univ, Dept Elect & Comp Engn, Lubbock, TX 79409 USA.
[Cole, Daniel P.] Motile Robot Inc, Joppa, MD USA.
[Behler, Kristopher D.] US Army, Res Lab, RDRL WMM E, Ceram & Transparent Mat Branch, Aberdeen Proving Ground, MD USA.
[Behler, Kristopher D.] Bowhead Sci & Technol, Belcamp, MD USA.
RP Green, MJ (reprint author), Texas Tech Univ, Dept Chem Engn, Lubbock, TX 79409 USA.
EM micah.green@ttu.edu
RI Hoque, Md Nadim Ferdous/K-2884-2013; Green, Micah/C-7647-2011
OI Hoque, Md Nadim Ferdous/0000-0002-0662-6915; Green,
Micah/0000-0001-5691-0861
FU U.S. National Science Foundation (NSF) [CMMI-1253085]; Air Force Office
of Scientific Research Young Investigator Program [AFOSR
FA9550-11-1-0027]; TTU Center for Undergraduate Research; NSF [MRI
04-511]; ARL-BST Program
FX The authors would like to acknowledge Rozana Bari, Shane Metzler, Dr.
Weile Yan, Dr. Sanjoy K. Bhattacharia, Dr. Brandon L. Weeks, and Dr.
Ronald Hedden of TTU for helpful insight as well as N. Arsalani and H.
Fattahi of the University of Tabriz for synthesis advice. Funding was
provided by the U.S. National Science Foundation (NSF) under CAREER
award CMMI-1253085 and by the Air Force Office of Scientific Research
Young Investigator Program (AFOSR FA9550-11-1-0027), and by the TTU
Center for Undergraduate Research. DLS measurements were conducted in
the Materials Characterization Center with the support of Dr. Juliusz
Warzywoda and Dr. Al Sacco of TTU. We also acknowledge the TTU Imaging
Center (funded by NSF MRI 04-511) supported by Professor Lauren S.
Gollahon for the HRTEM images. Dr. K. Behler is a Bowhead Science and
Technology (BST) Senior Scientist at ARL, and he gratefully acknowledges
support from the ARL-BST Program.
NR 19
TC 6
Z9 6
U1 3
U2 99
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0008-6223
EI 1873-3891
J9 CARBON
JI Carbon
PD JUN
PY 2014
VL 72
BP 192
EP 199
DI 10.1016/j.carbon.2014.02.002
PG 8
WC Chemistry, Physical; Materials Science, Multidisciplinary
SC Chemistry; Materials Science
GA AE5EM
UT WOS:000334010600022
ER
PT J
AU Quraishi, Q
Diddams, SA
Hollberg, L
AF Quraishi, Qudsia
Diddams, Scott A.
Hollberg, Leo
TI Optical phase-noise dynamics of Titanium:sapphire optical frequency
combs
SO OPTICS COMMUNICATIONS
LA English
DT Article
DE Ultrafast; Phase noise; Optical reference; Frequency comb equation
ID METROLOGY; TERAHERTZ; OFFSET; LINK; ION
AB Stabilized optical frequency combs (OFC) can have remarkable levels of coherence across their broad spectral bandwidth. We study the scaling of the optical noise across hundreds of nanometers of optical spectra. We measure the residual phase noise between two OFC's (having offset frequencies f(0)((1)) and f(0)((2)) referenced to a common cavity-stabilized narrow linewidth CW laser. Their relative offset frequency Delta f(0) = f(0)((2))-f(0)((1)), which appears across their entire spectra, provides a convenient measure of the phase noise. By comparing Delta f(0) at different spectral regions, we demonstrate that the observed scaling of the residual phase noise is in very good agreement with the noise predicted from the standard frequency comb equation. (C) 2014 Published by Elsevier B.V.
C1 [Quraishi, Qudsia] Army Res Lab, Adelphi, MD 20783 USA.
[Diddams, Scott A.] Natl Inst Stand & Technol, Boulder, CO 80305 USA.
[Hollberg, Leo] Stanford Univ, Dept Phys, Stanford, CA 94305 USA.
RP Quraishi, Q (reprint author), Army Res Lab, Adelphi, MD 20783 USA.
EM qudsia.quraishi@gmail.com
NR 20
TC 0
Z9 0
U1 2
U2 34
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0030-4018
EI 1873-0310
J9 OPT COMMUN
JI Opt. Commun.
PD JUN 1
PY 2014
VL 320
BP 84
EP 87
DI 10.1016/j.optcom.2014.01.030
PG 4
WC Optics
SC Optics
GA AE2GM
UT WOS:000333791300015
ER
PT J
AU Ramirez, A
Arguello, H
Arce, GR
Sadler, BM
AF Ramirez, Ana
Arguello, Henry
Arce, Gonzalo R.
Sadler, Brian M.
TI Spectral Image Classification From Optimal Coded-Aperture Compressive
Measurements
SO IEEE TRANSACTIONS ON GEOSCIENCE AND REMOTE SENSING
LA English
DT Article
DE Classification; coded aperture; coded-aperture snapshot spectral imaging
(CASSI); hyperspectral imagery; principal component analysis (PCA);
restricted isometry property (RIP); sparsity
ID PRINCIPAL COMPONENT ANALYSIS; NEAREST-NEIGHBOR; PROJECTION;
RECONSTRUCTION; RECOVERY
AB Traditional hyperspectral imaging sensors acquire high-dimensional data that are used for the discrimination of objects and features in a scene. Recently, a novel architecture known as the coded-aperture snapshot spectral imaging (CASSI) system has been developed for the acquisition of compressive spectral image data with just a few coded focal plane array measurements. This paper focuses on developing a classification approach with hyperspectral images directly from CASSI compressive measurements, without first reconstructing the full data cube. The proposed classification method uses the compressive measurements to find the sparse vector representation of the test pixel in a given training dictionary. The estimated sparse vector is obtained by solving a sparsity-constrained optimization problem and is then used to directly determine the class of the unknown pixel. The performance of the proposed classifier is improved by taking optimal CASSI compressive measurements obtained when optimal coded apertures are used in the optical system. The set of optimal coded apertures is designed such that the CASSI sensing matrix satisfies a restricted isometry property with high probability. Several simulations illustrate the performance of the proposed classifier using optimal coded apertures and the gain in the classification accuracy obtained over using traditional aperture codes in CASSI.
C1 [Ramirez, Ana; Arguello, Henry; Arce, Gonzalo R.] Univ Delaware, Dept Elect & Comp Engn, Newark, DE 19716 USA.
[Sadler, Brian M.] US Army Res Lab, Adelphi, MD 20783 USA.
RP Ramirez, A (reprint author), Univ Delaware, Dept Elect & Comp Engn, Newark, DE 19716 USA.
FU Army Research Laboratory; Army Research Office [W911NF-11-1-0368];
National Science Foundation [EECS-0725422, CCF-0915800]; Office of Naval
Research [NOOO14-1O-C-0199]
FX Manuscript received November 5, 2012; revised March 24, 2013; accepted
June 28, 2013. This work was supported in part by the Army Research
Laboratory and the Army Research Office under Grant W911NF-11-1-0368 and
in part by the National Science Foundation under Grants EECS-0725422 and
CCF-0915800 and partially by the Office of Naval Research under Contract
NOOO14-1O-C-0199.
NR 32
TC 7
Z9 10
U1 2
U2 20
PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
PI PISCATAWAY
PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA
SN 0196-2892
EI 1558-0644
J9 IEEE T GEOSCI REMOTE
JI IEEE Trans. Geosci. Remote Sensing
PD JUN
PY 2014
VL 52
IS 6
BP 3299
EP 3309
DI 10.1109/TGRS.2013.2272378
PG 11
WC Geochemistry & Geophysics; Engineering, Electrical & Electronic; Remote
Sensing; Imaging Science & Photographic Technology
SC Geochemistry & Geophysics; Engineering; Remote Sensing; Imaging Science
& Photographic Technology
GA AC4QB
UT WOS:000332504700022
ER
PT J
AU El Bissati, K
Zhou, Y
Dasgupta, D
Cobb, D
Dubey, JP
Burkhard, P
Lanar, DE
McLeod, R
AF El Bissati, Kamal
Zhou, Ying
Dasgupta, Debleena
Cobb, Drew
Dubey, Jitender P.
Burkhard, Peter
Lanar, David E.
McLeod, Rima
TI Effectiveness of a novel immunogenic nanoparticle platform for
Toxoplasma peptide vaccine in HLA transgenic mice
SO VACCINE
LA English
DT Article
DE Toxoplasma gondii; HLA-B7; Vaccine; Nanoparticles
ID IFN-GAMMA; CONGENITAL TOXOPLASMOSIS; PROTECTIVE IMMUNITY; DENDRITIC
CELLS; GONDII; EXPRESSION; RESISTANCE; RESPONSES; GRA7; INFECTION
AB We created and produced a novel self-assembling nanoparticle platform for delivery of peptide epitopes that induces CD8(+) and CD4(+)T cells that are protective against Toxoplasma gondii infection. These selfassembling polypeptide nanoparticles (SAPNs) are composed of linear peptide (LP) monomers which contain two coiled-coil oligomerization domains, the dense granule 7 (GRA7(20-28) LPQFATAAT) peptide and a universal CD4(+)T cell epitope (derived from PADRE). Purified LPs assemble into nanoparticles with icosahedral symmetry, similar to the capsids of small viruses. These particles were evaluated for their efficacy in eliciting IFN-gamma by splenocytes of HLA-B(*)0702 transgenic mice and for their ability to protect against subsequent T. gondii challenge. This work demonstrates the feasibility of using this platform approach with a CD8(+) epitope that binds HLA-B7 and tests the biological activity of potentially protective peptides restricted by human major histocompatibility complex (HLA) class I molecules in HLA transgenic mice. (C) 2014 Elsevier Ltd. All rights reserved.
C1 [El Bissati, Kamal; Zhou, Ying; McLeod, Rima] Univ Chicago, Dept Surg, Chicago, IL 60637 USA.
[Dasgupta, Debleena; Lanar, David E.] Walter Reed Army Inst Res, Malaria Vaccine Branch, Silver Spring, MD 20910 USA.
[Cobb, Drew] George Washington Univ, Washington, DC 20037 USA.
[Dubey, Jitender P.] ARS, USDA, Beltsville Agr Res Ctr, Anim Parasit Dis Lab, Beltsville, MD 20705 USA.
[Burkhard, Peter] Univ Connecticut, Inst Mat Sci, Storrs, CT 06269 USA.
[Burkhard, Peter] Univ Connecticut, Dept Mol & Cell Biol, Storrs, CT 06269 USA.
RP El Bissati, K (reprint author), Univ Chicago, Dept Surg, 5841 S Maryland Ave, Chicago, IL 60637 USA.
EM kelbissati@uchicago.edu
FU DMID-NIAID [U01 A0177887, R01 27530]
FX We gratefully thank Kevin Muite and Ani Solanki for technical help,
Ernest Mui for helpful suggestions, Laura Knoll (Wisconsin) for the
luciferase expressing parasites, and Boris Streipen (University of
Georgia) for the RH-YFP parasites. We gratefully acknowledge support of
this work from the Mann Cornwell, Engel and RooneyAlden, Lange!,
Rosenthal and Jensen families. This work also was supported by
DMID-NIAID U01 A0177887, R01 27530 (to RM), Knights Templar Eye
Foundation (to KE), and The Research to Prevent Blindness Foundation (to
RM).
NR 33
TC 18
Z9 18
U1 1
U2 16
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0264-410X
EI 1873-2518
J9 VACCINE
JI Vaccine
PD MAY 30
PY 2014
VL 32
IS 26
BP 3243
EP 3248
DI 10.1016/j.vaccine.2014.03.092
PG 6
WC Immunology; Medicine, Research & Experimental
SC Immunology; Research & Experimental Medicine
GA AI4YL
UT WOS:000336872500020
PM 24736000
ER
PT J
AU Hu, FS
La Scala, JJ
Sadler, JM
Palmese, GR
AF Hu, Fengshuo
La Scala, John J.
Sadler, Joshua M.
Palmese, Giuseppe R.
TI Synthesis and Characterization of Thermosetting Furan-Based Epoxy
Systems
SO MACROMOLECULES
LA English
DT Article
ID DIELS-ALDER REACTION; RENEWABLE RESOURCES; POLYMER CHEMISTRY; DIGLYCIDYL
ETHER; BISPHENOL-A; BLENDS; RESINS; TEMPERATURE; BIOMASS; RELAXATIONS
AB Renewable alternatives to petroleum-based thermosetting polymers have drawn significant attention due to potential positive economic and ecological impact. New materials should mimic the rigid, phenylic structure of incumbent high-performance thermoset monomers. Furans derived from cellulose and hemicellulose are promising candidates for phenyl replacement. The synthesis of furan-based diepoxies is challenging, and direct property comparisons of thermosets prepared using furanyl and phenyl-based epoxy monomer analogues are required. In this work, analogous furanyl-based and phenyl-based diepoxy monomers were synthesized, and thermosets were prepared using amine curing agents. A structure property study showed that furan-based polymers possess improved T-g (Delta = 8-16 degrees C) and improved glassy modulus (Delta = 0.1 to 0.6 GPa) relative to their phenylic analogues. The furan ring has thus been demonstrated to be a viable building block for renewable high-performance epoxies, with potential for application in other thermosetting polymers.
C1 [Hu, Fengshuo; Palmese, Giuseppe R.] Drexel Univ, Dept Chem & Biol Engn, Philadelphia, PA 19104 USA.
[La Scala, John J.; Sadler, Joshua M.] Army Res Labs, Aberdeen Proving Ground, MD 21005 USA.
RP Palmese, GR (reprint author), Drexel Univ, Dept Chem & Biol Engn, Philadelphia, PA 19104 USA.
EM grp27@drexel.edu
FU SERDP [WP-1758]; U.S. Army Research Laboratory under the Army Materials
Center of Excellence Program [W911NF-06-2-0013]; China Scholarship
Council
FX We acknowledge financial support from SERDP under Project WP-1758 as
well as from the U.S. Army Research Laboratory under the Army Materials
Center of Excellence Program, contract W911NF-06-2-0013. Support from
the China Scholarship Council is also acknowledged. We thank the
Department of Chemistry at Drexel University for use of 1H
NMR, 13C NMR, and MS facilities.
NR 64
TC 33
Z9 33
U1 10
U2 88
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0024-9297
EI 1520-5835
J9 MACROMOLECULES
JI Macromolecules
PD MAY 27
PY 2014
VL 47
IS 10
BP 3332
EP 3342
DI 10.1021/ma500687t
PG 11
WC Polymer Science
SC Polymer Science
GA AI1VM
UT WOS:000336643300012
ER
PT J
AU Singh, VP
Cui, HJ
Byrd, AR
AF Singh, Vijay P.
Cui, Huijuan
Byrd, Aaron R.
TI Derivation of rating curve by the Tsallis entropy
SO JOURNAL OF HYDROLOGY
LA English
DT Article
DE Entropy; Rating curve; Principle of maximum entropy; Stage-discharge
relation; Tsallis entropy
ID STAGE-DISCHARGE RELATIONSHIP; NEURAL-NETWORKS; RIVER; MODEL; HYDRAULICS;
STREAMS
AB The stage-discharge relation, often called rating curve, is employed to determine discharge in natural and engineered channels. There are several methods for deriving a rating curve most of which are empirical. It is well recognized that rating curves are subjected to significant uncertainty, yet most of these methods do not have any provision to account for or do not quantify the uncertainty. This study employs the Tsallis entropy for deriving the rating curve, based on two simple constraints: (1) total probability and (2) mean discharge. Parameters of the derived curve are determined with the use of these two constraints. The rating curve is also determined by reparameterization with the use of an entropy parameter. The Tsallis entropy permits a probabilistic characterization of the rating curve and hence the probability density function of discharge underlying the curve. It also permits a quantitative assessment of the uncertainty of discharge obtained from the rating curve. The derived rating curve is found to be in agreement with field data and is also applied to ungaged watersheds. The rating curve is also extended beyond the range of discharge values used in its construction and its validity is then evaluated. Published by Elsevier B.V.
C1 [Singh, Vijay P.] Texas A&M Univ, Dept Biol & Agr Engn, College Stn, TX 77843 USA.
[Singh, Vijay P.] Texas A&M Univ, Zachry Dept Civil Engn, College Stn, TX 77843 USA.
[Cui, Huijuan] Texas A&M Univ, Water Management & Hydrol Sci Program, College Stn, TX 77843 USA.
[Byrd, Aaron R.] US Army Corps Engineers, Engineer Res Dev Ctr, Coastal & Hydraul Lab, Vicksburg, MS 39181 USA.
RP Cui, HJ (reprint author), Texas A&M Univ, Water Management & Hydrol Sci Program, College Stn, TX 77843 USA.
EM cui.huijuan@gmail.com
NR 41
TC 4
Z9 4
U1 0
U2 9
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0022-1694
EI 1879-2707
J9 J HYDROL
JI J. Hydrol.
PD MAY 26
PY 2014
VL 513
BP 342
EP 352
DI 10.1016/j.jhydrol.2014.03.061
PG 11
WC Engineering, Civil; Geosciences, Multidisciplinary; Water Resources
SC Engineering; Geology; Water Resources
GA AI9NI
UT WOS:000337258900032
ER
PT J
AU Idrees, M
Thangavelu, K
Sikaroodi, M
Smith, C
Sivaraman, J
Gillevet, PM
Bokhari, H
AF Idrees, M.
Thangavelu, K.
Sikaroodi, M.
Smith, C.
Sivaraman, J.
Gillevet, P. M.
Bokhari, H.
TI Novel fluorescent protein from Hydnophora rigida possesses green
emission
SO BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
LA English
DT Article
DE Hydnophora rigida; Novel green fluorescent protein; Cloning; Expression;
Modeling
ID MONOMERIC RED; EVOLUTION; MUTANTS; DIVERSITY; MARKER; ORANGE; CORAL; GFP
AB Fluorescent proteins are a family of proteins capable of producing fluorescence at various specific wavelengths of ultra violet light. We have previously reported the identification and characterization of a novel cyan fluorescent protein (HriCFP) from a reef coral species, Hydnophora rigida. In search of new members of the, diverse family of fluorescent proteins, here we report a new green fluorescent protein (HriGFP) from H. rigida. HriGFP was identified, cloned, expressed in Escherichia coli and purified to homogeneity by metal affinity and size exclusion chromatography. The dynamic light scattering and gel filtration experiments suggested the presence of monomers in solution. The peptide mass fingerprint on the purified protein established the identity of HriGFP. HriGFP had excitation peak at 507 nm and emission peak at 527 nm. HriGFP was similar to HriCFP except the last 16 amino acid sequence at the C-terminal; however, they have shown least similarity with other known fluorescent proteins. Moreover the computational model suggests that HriGFP is a globular protein which consists of 6 alpha-helices and 3 beta-sheets. Taken together our results suggested that HriGFP is a novel naturally occurring fluorescent protein that exists as a monomer in solution. (C) 2014 Elsevier Inc. All right reserved.
C1 [Idrees, M.; Bokhari, H.] COMSATS Inst Informat Technol, Dept Biosci, Islamabad, Pakistan.
[Smith, C.] US Army, Engn Res & Dev Ctr, Topog Engn Ctr, Alexandria, VA USA.
[Sikaroodi, M.; Smith, C.; Gillevet, P. M.] George Mason Univ, Microbiome Anal Ctr, Dept Environm Sci & Policy, Manassas, VA USA.
[Sivaraman, J.] Natl Univ Singapore, Dept Biol Sci, Singapore 117548, Singapore.
RP Bokhari, H (reprint author), COMSATS Inst Informat Technol, Dept Biosci, Pk Rd, Islamabad, Pakistan.
EM habib@comsats.edu.pk
RI idrees, muhammad/F-4415-2015; Bokhari, Syed Habib/J-2825-2015
FU Higher Education Commission of Pakistan through National Research
Support Program for Universities [HEC:760]; Academic Research Fund
(ARF), National University of Singapore (NUS), Singapore [WBS:
R154-000-563-112]
FX The author H.B. thanks the COMSATS Institute of Information Technology,
Islamabad: for encouragement and Higher Education Commission of Pakistan
for support through National Research Support Program for Universities
(Grant No. HEC:760). The author J.S. acknowledges the research support
from Academic Research Fund (ARF), National University of Singapore
(NUS), Singapore (Grant No. WBS: R154-000-563-112).
NR 29
TC 1
Z9 1
U1 0
U2 12
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0006-291X
EI 1090-2104
J9 BIOCHEM BIOPH RES CO
JI Biochem. Biophys. Res. Commun.
PD MAY 23
PY 2014
VL 448
IS 1
BP 33
EP 38
DI 10.1016/j.bbrc.2014.04.042
PG 6
WC Biochemistry & Molecular Biology; Biophysics
SC Biochemistry & Molecular Biology; Biophysics
GA AI0RY
UT WOS:000336558800006
PM 24747076
ER
PT J
AU Xu, K
Meshik, X
Nichols, BM
Zakar, E
Dutta, M
Stroscio, MA
AF Xu, Ke
Meshik, Xenia
Nichols, Barbara M.
Zakar, Eugene
Dutta, Mitra
Stroscio, Michael A.
TI Graphene- and aptamer-based electrochemical biosensor
SO NANOTECHNOLOGY
LA English
DT Article
DE DNA; field effect transistor; graphene; ion detection; thrombin binding
aptamer (TBA)
ID LABEL-FREE DETECTION; REAGENTLESS; TRANSISTORS; THROMBIN; LEAD(II);
SENSOR; IONS
AB This study investigated the effectiveness of a graphene- and aptamer-based field-effect-transistor-like (FET-like) sensor in detecting lead and potassium ions. The sensor consists of a graphene-covered Si/SiO2 wafer with thrombin binding aptamer (TBA) attached to the graphene layer and terminated by a methylene blue (MB) molecule. K+ and Pb2+ both bind to TBA and cause a conformational change, which results in MB moving closer to the graphene surface and donating an electron. Thus, the abundance of K+ and Pb2+ can be determined by monitoring the current across the source and drain channel. Device transfer curves were obtained with ambipolar field effect observed. Current readings were taken for K+ concentrations of 100 mu M to 50 mM and Pb2+ concentrations of 10 mu M to 10 mM. As expected, I-d decreased as ion concentration increased. In addition, there was a negative shift in V-Dirac in response to increased ion concentration.
C1 [Xu, Ke; Dutta, Mitra; Stroscio, Michael A.] Univ Illinois, Dept Elect & Comp Engn, Chicago, IL 60607 USA.
[Meshik, Xenia; Stroscio, Michael A.] Univ Illinois, Dept Bioengn, Chicago, IL 60607 USA.
[Nichols, Barbara M.; Zakar, Eugene] US Army Res Lab, Sensors & Elect Devices Directorate, Adelphi, MD 20783 USA.
RP Xu, K (reprint author), Univ Illinois, Dept Elect & Comp Engn, Chicago, IL 60607 USA.
EM stroscio@uic.edu
FU Army Research Office (ARO) through MURI [W911NF-11-1-0024]
FX This work was supported by Army Research Office (ARO) through MURI grant
W911NF-11-1-0024.
NR 27
TC 10
Z9 11
U1 3
U2 105
PU IOP PUBLISHING LTD
PI BRISTOL
PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND
SN 0957-4484
EI 1361-6528
J9 NANOTECHNOLOGY
JI Nanotechnology
PD MAY 23
PY 2014
VL 25
IS 20
AR 205501
DI 10.1088/0957-4484/25/20/205501
PG 8
WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary;
Physics, Applied
SC Science & Technology - Other Topics; Materials Science; Physics
GA AG6FW
UT WOS:000335515500007
PM 24785149
ER
PT J
AU Videnovic, M
Opsenica, DM
Burnett, JC
Gomba, L
Nuss, JE
Selakovic, Z
Konstantinovic, J
Krstic, M
Segan, S
Zlatovic, M
Sciotti, RJ
Bavari, S
Solaja, BA
AF Videnovic, Milica
Opsenica, Dejan M.
Burnett, James C.
Gomba, Laura
Nuss, Jonathan E.
Selakovic, Zivota
Konstantinovic, Jelena
Krstic, Maja
Segan, Sandra
Zlatovic, Mario
Sciotti, Richard J.
Bavari, Sina
Solaja, Bogdan A.
TI Second Generation Steroidal 4-Aminoquinolines Are Potent, Dual-Target
Inhibitors of the Botulinum Neurotoxin Serotype A Metalloprotease and P.
falciparum Malaria
SO JOURNAL OF MEDICINAL CHEMISTRY
LA English
DT Article
ID BETA-HEMATIN INHIBITION; ANTIMALARIAL ACTIVITY; LIGHT-CHAIN; IN-VITRO;
NEUROTRANSMITTER RELEASE; CHLOROQUINE-RESISTANT; PROTEOLYTIC ACTIVITY;
CYTOTOXIC ACTIVITY; DRUG DISCOVERY; SUBSTRATE
AB Significantly more potent second generation 4-amino-7-chloroquinoline (4,7-ACQ) based inhibitors of the botulinum neurotoxin serotype A (BoNT/A) light chain were synthesized. Introducing an amino group at the C(3) position of the cholate component markedly increased potency (IC50 values for such derivatives ranged from 0.81 to 2.27 mu M). Two additional subclasses were prepared: bis(steroidal)-4,7-ACQ derivatives and bis(4,7-ACQ)cholate derivatives; both classes provided inhibitors with nanomolar-range potencies (e.g., the K-i of compound 67 is 0.10 mu M). During BoNT/A challenge using primary neurons, select derivatives protected SNAP-25 by up to 89%. Docking simulations were performed to rationalize the compounds' in vitro potencies. In addition to specific residue contacts, coordination of the enzyme's catalytic zinc and expulsion of the enzyme's catalytic water were a consistent theme. With respect to antimalarial activity, the compounds provided better IC90 activities against chloroquine resistant (CQR) malaria than CQ, and seven compounds were more active than mefloquine against CQR strain W2.
C1 [Videnovic, Milica; Selakovic, Zivota; Krstic, Maja; Zlatovic, Mario; Solaja, Bogdan A.] Univ Belgrade, Fac Chem, Belgrade 11158, Serbia.
[Opsenica, Dejan M.; Segan, Sandra] Univ Belgrade, Inst Chem Technol & Met, Belgrade 11000, Serbia.
[Burnett, James C.] Leidos Biomed Res Inc, FNLCR Frederick, Computat Drug Dev Grp, Frederick, MD 21701 USA.
[Gomba, Laura; Nuss, Jonathan E.] US Army Med Res Inst Infect Dis, Dept Bacteriol, Frederick, MD 21702 USA.
[Konstantinovic, Jelena] Fac Chem Innovat Ctr, Belgrade 11158, Serbia.
[Sciotti, Richard J.] Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD 20910 USA.
[Bavari, Sina] US Army Med Res Inst Infect Dis, Frederick, MD 21702 USA.
RP Opsenica, DM (reprint author), Univ Belgrade, Inst Chem Technol & Met, Njegoseva 12, Belgrade 11000, Serbia.
EM dopsen@chem.bg.ac.rs; jnuss@genevausa.org; sina.bavari.civ@mail.mil;
bsolaja@chem.bg.ac.rs
RI Zlatovic, Mario/E-5874-2015; Konstantinovic, Jelena/Q-5813-2016;
OI Zlatovic, Mario/0000-0003-4311-1731; Konstantinovic,
Jelena/0000-0002-2572-8538; Solaja, Bogdan/0000-0002-9975-2725;
Videnovic, Milica/0000-0001-5606-2401
FU National Institute of Allergy and Infectious Diseases (U.S.)
[5-U01AI082051-02]; Ministry of Science and Technological Development of
Serbia [172008]; National Cancer Institute, National Institutes of
Health (U.S.) [HHSN261200800001E]
FX The authors thank Dr. Nicoletta Basilico (Dipartimento di Sanita
Pubblica-Microbiologia-Virologia, Universita degli Studi di Milano,
Italy) for beta-hematin formation inhibition experiments. This research
was supported by National Institute of Allergy and Infectious Diseases
(U.S.) Grant 5-U01AI082051-02 and by the Ministry of Science and
Technological Development of Serbia (Grant 172008). Furthermore, for
J.C.B., the following statement is in compliance with Leidos Biomedical
Research, Inc. contractual requirements: This project has been funded in
whole or in part with federal funds from the National Cancer Institute,
National Institutes of Health (U.S.), under Contract HHSN261200800001E.
The content of this publication does not necessarily reflect the views
or policies of the Department of Health and Human Services (U.S.) or the
U.S. Army, nor does the mention of trade names, commercial products, or
organizations imply endorsement by the U.S. Government or the U.S. Army.
NR 86
TC 11
Z9 11
U1 0
U2 8
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0022-2623
EI 1520-4804
J9 J MED CHEM
JI J. Med. Chem.
PD MAY 22
PY 2014
VL 57
IS 10
BP 4134
EP 4153
DI 10.1021/jm500033r
PG 20
WC Chemistry, Medicinal
SC Pharmacology & Pharmacy
GA AI0BB
UT WOS:000336510100017
PM 24742203
ER
PT J
AU Olson, MA
Lee, MS
AF Olson, Mark A.
Lee, Michael S.
TI Evaluation of Unrestrained Replica-Exchange Simulations Using Dynamic
Walkers in Temperature Space for Protein Structure Refinement
SO PLOS ONE
LA English
DT Article
ID GUIDED LANGEVIN DYNAMICS; MOLECULAR-DYNAMICS; STRUCTURE PREDICTION;
STRUCTURE SELECTION; I-TASSER; CONFORMATIONS; MODELS; FORCE; CASP9
AB A central problem of computational structural biology is the refinement of modeled protein structures taken from either comparative modeling or knowledge-based methods. Simulations are commonly used to achieve higher resolution of the structures at the all-atom level, yet methodologies that consistently yield accurate results remain elusive. In this work, we provide an assessment of an adaptive temperature-based replica exchange simulation method where the temperature clients dynamically walk in temperature space to enrich their population and exchanges near steep energetic barriers. This approach is compared to earlier work of applying the conventional method of static temperature clients to refine a dataset of conformational decoys. Our results show that, while an adaptive method has many theoretical advantages over a static distribution of client temperatures, only limited improvement was gained from this strategy in excursions of the downhill refinement regime leading to an increase in the fraction of native contacts. To illustrate the sampling differences between the two simulation methods, energy landscapes are presented along with their temperature client profiles.
C1 [Olson, Mark A.] USAMRIID, Dept Cell Biol & Biochem Mol & Translat Sci, Frederick, MD USA.
[Olson, Mark A.] Johns Hopkins Univ, Zanvyl Krieger Sch Arts & Sci, Adv Acad Programs, Baltimore, MD USA.
[Lee, Michael S.] US Army Res Lab, Computat Sci Div, Aberdeen Proving Ground, MD USA.
RP Olson, MA (reprint author), USAMRIID, Dept Cell Biol & Biochem Mol & Translat Sci, Frederick, MD USA.
EM molson@compbiophys.org
FU U.S. Department of Defense Threat Reduction Agency
[CBCALL12-LS6-2-0036]; Army Research Lab
FX Funding of this research was provided by the U.S. Department of Defense
Threat Reduction Agency Grant CBCALL12-LS6-2-0036 to MAO and the Army
Research Lab to MSL. The funders had no role in study design, data
collection and analysis, decision to publish, or preparation of the
manuscript.
NR 37
TC 3
Z9 3
U1 1
U2 7
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD MAY 21
PY 2014
VL 9
IS 5
AR e96638
DI 10.1371/journal.pone.0096638
PG 9
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA AI3AL
UT WOS:000336730600014
PM 24848767
ER
PT J
AU Stojadinovic, A
Millia, SZ
Feldman, R
Avital, I
AF Stojadinovic, Alexander
Millia, Sherri Z.
Feldman, Rebecca
Avital, Itzhak
TI Molecular profiling of thyroid cancers
SO JOURNAL OF CLINICAL ONCOLOGY
LA English
DT Meeting Abstract
CT 50th Annual Meeting of the American-Society-of-Clinical-Oncology
CY MAY 30-JUN 03, 2014
CL Chicago, IL
SP Amer Soc Clin Oncol
C1 Walter Reed Army Med Ctr, Washington, DC 20307 USA.
Caris Life Sci, Phoenix, AZ USA.
Bon Secours Canc Inst, Richmond, VA USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER SOC CLINICAL ONCOLOGY
PI ALEXANDRIA
PA 2318 MILL ROAD, STE 800, ALEXANDRIA, VA 22314 USA
SN 0732-183X
EI 1527-7755
J9 J CLIN ONCOL
JI J. Clin. Oncol.
PD MAY 20
PY 2014
VL 32
IS 15
SU S
MA e17008
PG 1
WC Oncology
SC Oncology
GA CN7KL
UT WOS:000358613200918
ER
PT J
AU Amani, M
Chin, ML
Mazzoni, AL
Burke, RA
Najmaei, S
Ajayan, PM
Lou, J
Dubey, M
AF Amani, Matin
Chin, Matthew L.
Mazzoni, Alexander L.
Burke, Robert A.
Najmaei, Sina
Ajayan, Pulickel M.
Lou, Jun
Dubey, Madan
TI Growth-substrate induced performance degradation in chemically
synthesized monolayer MoS2 field effect transistors
SO APPLIED PHYSICS LETTERS
LA English
DT Article
ID HIGH-QUALITY MONOLAYER; VAPOR-PHASE GROWTH; BILAYER MOS2; 2-DIMENSIONAL
MATERIALS; MOLYBDENUM-DISULFIDE; ATOMIC LAYERS; GRAPHENE; FILMS;
PHOTOLUMINESCENCE; HETEROSTRUCTURES
AB We report on the electronic transport properties of single-layer thick chemical vapor deposition (CVD) grown molybdenum disulfide (MoS2) field-effect transistors (FETs) on Si/SiO2 substrates. MoS2 has been extensively investigated for the past two years as a potential semiconductor analogue to graphene. To date, MoS2 samples prepared via mechanical exfoliation have demonstrated field-effect mobility values which are significantly higher than that of CVD-grown MoS2. In this study, we will show that the intrinsic electronic performance of CVD-grown MoS2 is equal or superior to that of exfoliated material and has been possibly masked by a combination of interfacial contamination on the growth substrate and residual tensile strain resulting from the high-temperature growth process. We are able to quantify this strain in the as-grown material using pre- and post-transfer metrology and microscopy of the same crystals. Moreover, temperature-dependent electrical measurements made on as-grown and transferred MoS2 devices following an identical fabrication process demonstrate the improvement in field-effect mobility. (C) 2014 AIP Publishing LLC.
C1 [Amani, Matin; Chin, Matthew L.; Mazzoni, Alexander L.; Burke, Robert A.; Dubey, Madan] US Army Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20723 USA.
[Najmaei, Sina; Ajayan, Pulickel M.; Lou, Jun] Rice Univ, Dept Mat Sci & Nanoengn, Houston, TX 77005 USA.
RP Dubey, M (reprint author), US Army Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20723 USA.
EM madan.dubey.civ@mail.mil
FU U.S. Army Research Lab (ARL) Director's Strategic Initiative (DSI)
program on interfaces in stacked 2D atomic layered materials; Welch
Foundation [C-1716]; NSF [DMR-1327093]; U.S. Army Research Office MURI
[W911NF-11-1-0362]; U.S. Office of Naval Research MURI
[N000014-09-1066]; Nanoelectronics Research Corporation [S201006]
FX M.A., M. L. C., A. L. M., R. A. B., and M. D. acknowledge the support of
the U.S. Army Research Lab (ARL) Director's Strategic Initiative (DSI)
program on interfaces in stacked 2D atomic layered materials. The
authors would also like to thank Dr. Pani Varanasi of the Army Research
Office for his in-depth technical discussion on 2D atomic layers R&D.
S.N., P. M. A., and J.L. acknowledge the support by the Welch Foundation
Grant C-1716, NSF Grant DMR-1327093, the U.S. Army Research Office MURI
Grant W911NF-11-1-0362, the U.S. Office of Naval Research MURI Grant
N000014-09-1066, and the Nanoelectronics Research Corporation Contract
S201006.
NR 39
TC 17
Z9 17
U1 6
U2 109
PU AMER INST PHYSICS
PI MELVILLE
PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1,
MELVILLE, NY 11747-4501 USA
SN 0003-6951
EI 1077-3118
J9 APPL PHYS LETT
JI Appl. Phys. Lett.
PD MAY 19
PY 2014
VL 104
IS 20
AR 203506
DI 10.1063/1.4873680
PG 5
WC Physics, Applied
SC Physics
GA AI8EQ
UT WOS:000337140800075
ER
PT J
AU Fernandes, GE
Kim, JH
Chin, M
Dhar, N
Xu, J
AF Fernandes, Gustavo E.
Kim, Jin Ho
Chin, Matthew
Dhar, Nibir
Xu, Jimmy
TI Carbon nanotube microbolometers on suspended silicon nitride via
vertical fabrication procedure
SO APPLIED PHYSICS LETTERS
LA English
DT Article
ID COMPOSITE
AB We report on carbon nanotube membrane microbolometers, operating uncooled in the near-infrared (IR) and mid-IR band, with speed of 10ms and responsivity of several kV/W. The microbolometers were fabricated using a vertical process on a thin suspended silicon nitride film for thermal isolation. The measured detectivity was similar to 5.5 x 10(6) cm Hz(1/2) W-1 at 40 Hz. The broadband spectral responses measured at room temperature over the entire band of the IR illumination source are characteristic of bolometric response. These results are indicative of the potential of this platform for uncooled IR sensing and thermal imaging. The measured device noise indicated a relatively strong 1/f contribution, which is common of carbon nanotube devices operated in atmospheric conditions. The observed responses suggest, however, that oxygen adsorption/desorption reported by some researchers did not play a significant role in these devices. (C) 2014 AIP Publishing LLC.
C1 [Fernandes, Gustavo E.; Kim, Jin Ho; Xu, Jimmy] Brown Univ, Sch Engn, Providence, RI 02912 USA.
[Chin, Matthew; Dhar, Nibir] Army Res Lab, Adelphi, MD 20783 USA.
RP Fernandes, GE (reprint author), Brown Univ, Sch Engn, 182 Hope St,Box D, Providence, RI 02912 USA.
EM gustavo_fernandes@brown.edu
FU U.S. Army Research Laboratory (ARL) [W911NF-12-2-0069]
FX We gratefully acknowledge the support of U.S. Army Research Laboratory
(ARL) Contract No. W911NF-12-2-0069. We thank Dr. Madan Dubey (ARL) for
guiding discussions and for his enabling support.
NR 14
TC 1
Z9 1
U1 2
U2 10
PU AMER INST PHYSICS
PI MELVILLE
PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1,
MELVILLE, NY 11747-4501 USA
SN 0003-6951
EI 1077-3118
J9 APPL PHYS LETT
JI Appl. Phys. Lett.
PD MAY 19
PY 2014
VL 104
IS 20
AR 201115
DI 10.1063/1.4879542
PG 4
WC Physics, Applied
SC Physics
GA AI8EQ
UT WOS:000337140800015
ER
PT J
AU Walsh, MR
Walsh, ME
Gagnon, K
Hewitt, AD
Jenkins, TF
AF Walsh, M. R.
Walsh, M. E.
Gagnon, K.
Hewitt, A. D.
Jenkins, T. F.
TI Subsampling of Soils Containing Energetics Residues
SO SOIL & SEDIMENT CONTAMINATION
LA English
DT Article
DE Subsampling error; soils; particulate contaminants; energetics;
replicates; grinding; subsampling increments; EPA Method 8330B
ID LIVE-FIRE; VARIANCE
AB There are many sources of error on the path from field sample acquisition to subsample analysis. This paper examines one potential source, the subsampling of a processed field sample. Five archived ground field samples were subsampled to determine the optimal number of increments to construct a 10-g subsample. Bulk samples ranged from 338g to 2150g. The analytes were energetic compounds: crystalline, easy-to-grind explosives and difficult-to-grind propellants in a nitrocellulose matrix. A two-phase study was conducted with moderately high concentration samples and low concentration samples of each type of analyte. All samples were ground with a puck mill according to EPA method 8330B and analyzed on liquid chromatography instrumentation. Up to 40 increments were used to build each subsample and seven replicates executed for each test. Results demonstrate that for a well-ground and mixed sample, a single 10g subsample is sufficient. For triplicate subsamples, however, 20 to 40 increments will give a result much closer to the concentration of the bulk sample. To minimize overall error due to incomplete mixing, improper grinding, or very low concentrations, we recommend about 30 increments be taken over the complete sample to construct the subsample.
C1 [Walsh, M. R.; Walsh, M. E.; Gagnon, K.; Hewitt, A. D.; Jenkins, T. F.] USA CRREL, Hanover, NH 03775 USA.
RP Walsh, MR (reprint author), USA CRREL, 72 Lyme Rd, Hanover, NH 03775 USA.
EM Michael.Walsh@usace.army.mil
NR 11
TC 2
Z9 2
U1 1
U2 13
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA
SN 1532-0383
EI 1549-7887
J9 SOIL SEDIMENT CONTAM
JI Soil. Sediment. Contam.
PD MAY 19
PY 2014
VL 23
IS 4
BP 452
EP 463
DI 10.1080/15320383.2014.838208
PG 12
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA 273KG
UT WOS:000328533100006
ER
PT J
AU Geiculescu, OE
Hallac, BB
Rajagopal, RV
Creager, SE
DesMarteau, DD
Borodin, O
Smith, GD
AF Geiculescu, Olt E.
Hallac, Boutros B.
Rajagopal, Rama V.
Creager, Stephen E.
DesMarteau, Darryl D.
Borodin, Oleg
Smith, Grant D.
TI The Effect of Low-Molecular-Weight Poly(ethylene glycol) (PEG)
Plasticizers on the Transport Properties of Lithium Fluorosulfonimide
Ionic Melt Electrolytes
SO JOURNAL OF PHYSICAL CHEMISTRY B
LA English
DT Article
ID POLARIZABLE FORCE-FIELDS; DYNAMICS SIMULATIONS; POLYMER ELECTROLYTES;
LI+ TRANSPORT; SALT HYBRID; CONDUCTIVITY; LITFSI; LIQUIDS; CARBONATE;
OLIGOETHER
AB The influence of low-molecular-weight poly(ethylene glycol) (PEG, M-w approximate to 550 Da) plasticizers on the rheology and ion-transport properties of fluorosulfonimide-based polyether ionic melt (IM) electrolytes has been investigated experimentally and via molecular dynamics (MD) simulations. Addition of PEG plasticizer to samples of IM electrolytes caused a decrease in electrolyte viscosity coupled to an increase in ionic conductivity. MD simulations revealed that addition of plasticizer increased self-diffusion coefficients for both cations and anions with the plasticizer being the fastest diffusing species. Application of a VTF model to fit variable-temperature conductivity and fluidity data shows that plasticization decreases the apparent activation energy (E-a) and pre-exponential factor A for ion transport and also for viscous flow. Increased ionic conductivity with plasticization is thought to reflect a combination of factors including lower viscosity and faster polyether chain segmental dynamics in the electrolyte, coupled with a change in the ion transport mechanism to favor ion solvation and transport by polyethers derived from the plasticizer. Current interrupt experiments with Li/electrolyte/ Li cells revealed evidence for salt concentration polarization in electrolytes containing large amounts of plasticizer but not in electrolytes without added plasticizer.
C1 [Geiculescu, Olt E.; Hallac, Boutros B.; Rajagopal, Rama V.; Creager, Stephen E.; DesMarteau, Darryl D.] Clemson Univ, Dept Chem, Clemson, SC 29634 USA.
[Borodin, Oleg] US Army, Res Lab, Electrochem Branch, Adelphi, MD 20783 USA.
[Borodin, Oleg; Smith, Grant D.] Univ Utah, Dept Mat Sci & Engn, Salt Lake City, UT 84112 USA.
[Smith, Grant D.] Wasatch Mol Inc, Salt Lake City, UT 84103 USA.
RP Creager, SE (reprint author), Clemson Univ, Dept Chem, Clemson, SC 29634 USA.
RI Borodin, Oleg/B-6855-2012
OI Borodin, Oleg/0000-0002-9428-5291
FU Office of FreedomCAR and Vehicle Technologies of the U.S. Department of
Energy [DE-AC02-05CH11231, 6515401, 6515399]; U.S. Department of Energy
[DE-IA01-11EE003413]; U.S. Army Research Laboratory
FX The authors are grateful for the financial support of this work by the
Assistant Secretary for Energy Efficiency and Renewable Energy, Office
of FreedomCAR and Vehicle Technologies of the U.S. Department of Energy
under Contract No. DE-AC02-05CH11231 on PO No. 6515401 (University of
Utah) and PO No. 6515399 (Clemson University), and an Interagency
Agreement DE-IA01-11EE003413 between the U.S. Department of Energy and
the U.S. Army Research Laboratory.
NR 53
TC 3
Z9 3
U1 0
U2 37
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 1520-6106
J9 J PHYS CHEM B
JI J. Phys. Chem. B
PD MAY 15
PY 2014
VL 118
IS 19
BP 5135
EP 5143
DI 10.1021/jp500826c
PG 9
WC Chemistry, Physical
SC Chemistry
GA AH5VL
UT WOS:000336199100017
PM 24773589
ER
PT J
AU Cravotta, CA
Goode, DJ
Bartles, MD
Risser, DW
Galeone, DG
AF Cravotta, Charles A., III
Goode, Daniel J.
Bartles, Michael D.
Risser, Dennis W.
Galeone, Daniel G.
TI Surface water and groundwater interactions in an extensively mined
watershed, upper Schuylkill River, Pennsylvania, USA
SO HYDROLOGICAL PROCESSES
LA English
DT Article
DE abandoned mines; acid mine drainage; mine hydrology; geochemical model;
groundwater model; hydrograph analysis
ID COAL-MINE; TRANSPORT; DRAINAGE; EVOLUTION; SULFATE; ACIDITY; METALS;
IRON; FATE
AB Streams crossing underground coal mines may lose flow, whereas abandoned mine drainage (AMD) restores flow downstream. During 2005-2012, discharge from the Pine Knot Mine Tunnel, the largest AMD source in the upper Schuylkill River Basin, had near-neutral pH and elevated concentrations of iron, manganese and sulphate. Discharge from the tunnel responded rapidly to recharge but exhibited a prolonged recession compared with nearby streams, consistent with rapid infiltration of surface water and slow release of groundwater from the mine complex. Dissolved iron was attenuated downstream by oxidation and precipitation, whereas dissolved CO2 degassed and pH increased. During high flow conditions, the AMD and downstream waters exhibited decreased pH, iron and sulphate with increased acidity that were modelled by mixing net-alkaline AMD with recharge or run-off having low ionic strength and low pH. Attenuation of dissolved iron within the river was least effective during high flow conditions because of decreased transport time coupled with inhibitory effects of low pH on oxidation kinetics. A numerical model of groundwater flow was calibrated by using groundwater levels in the Pine Knot Mine and discharge data for the Pine Knot Mine Tunnel and West Branch Schuylkill River during a snowmelt event in January 2012. Although the calibrated model indicated substantial recharge to the mine complex took place away from streams, simulation of rapid changes in mine pool level and tunnel discharge during a high flow event in May 2012 required a source of direct recharge to the Pine Knot Mine. Such recharge produced small changes in mine pool level and rapid changes in tunnel flow rate because of extensive unsaturated storage capacity and high transmissivity within the mine complex. Thus, elimination of stream leakage could have a small effect on the annual discharge from the tunnel, but a large effect on peak discharge and associated water quality downstream. Published 2013. This article is a U.S. Government work and is in the public domain in the USA.
C1 [Cravotta, Charles A., III; Goode, Daniel J.; Risser, Dennis W.; Galeone, Daniel G.] US Geol Survey, Penn Water Sci Ctr, University Pk, PA 16802 USA.
[Bartles, Michael D.] US Army Corps Engineers, Philadelphia, PA USA.
RP Cravotta, CA (reprint author), US Geol Survey, Penn Water Sci Ctr, University Pk, PA 16802 USA.
EM cravotta@usgs.gov
OI Goode, Daniel/0000-0002-8527-2456
NR 70
TC 9
Z9 9
U1 7
U2 54
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0885-6087
EI 1099-1085
J9 HYDROL PROCESS
JI Hydrol. Process.
PD MAY 15
PY 2014
VL 28
IS 10
BP 3574
EP 3601
DI 10.1002/hyp.9885
PG 28
WC Water Resources
SC Water Resources
GA AG8JD
UT WOS:000335663700005
ER
PT J
AU Brown, CS
Lee, MS
Leung, DW
Wang, TJ
Xu, W
Luthra, P
Anantpadma, M
Shabman, RS
Melito, LM
MacMillan, KS
Borek, DM
Otwinowski, Z
Ramanan, P
Stubbs, AJ
Peterson, DS
Binning, JM
Tonelli, M
Olson, MA
Davey, RA
Ready, JM
Basler, CF
Amarasinghe, GK
AF Brown, Craig S.
Lee, Michael S.
Leung, Daisy W.
Wang, Tianjiao
Xu, Wei
Luthra, Priya
Anantpadma, Manu
Shabman, Reed S.
Melito, Lisa M.
MacMillan, Karen S.
Borek, Dominika M.
Otwinowski, Zbyszek
Ramanan, Parameshwaran
Stubbs, Alisha J.
Peterson, Dayna S.
Binning, Jennifer M.
Tonelli, Marco
Olson, Mark A.
Davey, Robert A.
Ready, Joseph M.
Basler, Christopher F.
Amarasinghe, Gaya K.
TI In Silico Derived Small Molecules Bind the Filovirus VP35 Protein and
Inhibit Its Polymerase Cofactor Activity
SO JOURNAL OF MOLECULAR BIOLOGY
LA English
DT Article
ID DOUBLE-STRANDED-RNA; EBOLA-VIRUS; INTERFERON ANTAGONISM; ZAIRE
EBOLAVIRUS; DENDRITIC CELLS; DOMAIN; TRANSCRIPTION; PATHOGENESIS;
REPLICATION; KARYOPHERIN
AB The Ebola virus (EBOV) genome only encodes a single viral polypeptide with enzymatic activity, the viral large (L) RNA-dependent RNA polymerase protein. However, currently, there is limited information about the L protein, which has hampered the development of antivirals. Therefore, antifiloviral therapeutic efforts must include additional targets such as protein-protein interfaces. Viral protein 35 (VP35) is multifunctional and plays important roles in viral pathogenesis, including viral mRNA synthesis and replication of the negative-sense RNA viral genome. Previous studies revealed that mutation of key basic residues within the VP35 interferon inhibitory domain (IID) results in significant EBOV attenuation, both in vitro and in vivo. In the current study, we use an experimental pipeline that includes structure-based in silico screening and biochemical and structural characterization, along with medicinal chemistry, to identify and characterize small molecules that target a binding pocket within VP35. NMR mapping experiments and high-resolution x-ray crystal structures show that select small molecules bind to a region of VP35 IID that is important for replication complex formation through interactions with the viral nucleoprotein (NP). We also tested select compounds for their ability to inhibit VP35 IID-NP interactions in vitro as well as VP35 function in a minigenome assay and EBOV replication. These results confirm the ability of compounds identified in this study to inhibit VP35-NP interactions in vitro and to impair viral replication in cell-based assays. These studies provide an initial framework to guide development of antifiloviral compounds against filoviral VP35 proteins. (C) 2014 Elsevier Ltd. All rights reserved.
C1 [Brown, Craig S.; Leung, Daisy W.; Xu, Wei; Ramanan, Parameshwaran; Binning, Jennifer M.; Amarasinghe, Gaya K.] Washington Univ, Sch Med, Dept Pathol & Immunol, St Louis, MO 63110 USA.
[Brown, Craig S.; Wang, Tianjiao; Stubbs, Alisha J.; Peterson, Dayna S.] Iowa State Univ, Roy J Carver Dept Biochem Biophys & Mol Biol, Ames, IA 50011 USA.
[Brown, Craig S.; Stubbs, Alisha J.; Peterson, Dayna S.] Iowa State Univ, Biochem Undergrad Program, Ames, IA 50011 USA.
[Lee, Michael S.] US Army Res Lab, Simulat Sci Branch, Aberdeen, MD 21005 USA.
[Lee, Michael S.; Olson, Mark A.] USAMRIID, Dept Cell Biol & Biochem, Ft Detrick, MD 21702 USA.
[Luthra, Priya; Shabman, Reed S.; Basler, Christopher F.] Icahn Sch Med Mt Sinai, Dept Microbiol, New York, NY 10029 USA.
[Anantpadma, Manu; Davey, Robert A.] Texas Biomed Res Inst, Dept Virol & Immunol, San Antonio, TX 78227 USA.
[Melito, Lisa M.; MacMillan, Karen S.; Borek, Dominika M.; Otwinowski, Zbyszek; Ready, Joseph M.] Univ Texas SW Med Ctr Dallas, Dept Biochem, Dallas, TX 75390 USA.
[Borek, Dominika M.; Otwinowski, Zbyszek] Univ Texas SW Med Ctr Dallas, Dept Biophys, Dallas, TX 75390 USA.
[Borek, Dominika M.; Otwinowski, Zbyszek] Ctr Struct Genom Infect Dis, Chicago, IL USA.
[Ramanan, Parameshwaran; Binning, Jennifer M.] Iowa State Univ, Biochem Grad Program, Ames, IA 50011 USA.
[Tonelli, Marco] Univ Wisconsin, Natl Magnet Resonance Facil Madison, Madison, WI 53706 USA.
RP Amarasinghe, GK (reprint author), Washington Univ, Sch Med, Dept Pathol & Immunol, St Louis, MO 63110 USA.
EM gamarasinghe@path.wustl.edu
RI Borek, Dominika/D-2943-2011;
OI Borek, Dominika/0000-0002-4321-6253; Anantpadma,
Manu/0000-0001-5796-532X; Shabman, Reed/0000-0003-3272-3484
FU U.S. Department of Energy [DE-AC02-06CH11357]; Center for Structural
Genomics of Infectious Diseases under the NIAID/NIH/DHS
[HHSN272200700058C, HHSN272201200026C]; National Institutes of Health
[R01AI081914, R01AI059536, R56AI089547, R56AI093786, R21AI097568,
P41RR02301, P41GM66326, RR02781, RR08438]; Midwest Regional Center of
Excellence Developmental Grant [U54AI057160-Virgin]; Welch Foundation
[I-1612]; DoD Defense Threat Reduction Agency [4.10011_07_RD_B];
National Magnetic Resonance Facility at Madison; University of
Wisconsin; National Science Foundation [DMB-8415048, OIA-9977486,
BIR-9214394]; U.S. Department of Agriculture
FX We thank Drs. S. Ginell, N. Duke, F. Rotella, K. Lazarski, and J. Lazarz
at Argonne National Laboratory Structural Biology Center Beam lines
(SBC). SBC is supported by the U.S. Department of Energy under contract
DE-AC02-06CH11357. D.M.B. and Z.O. are supported in part by the Center
for Structural Genomics of Infectious Diseases under the NIAID/NIH/DHS
Contracts HHSN272200700058C and HHSN272201200026C Anderson (PI). This
work is supported in part by National Institutes of Health grants
(R01AI081914 to G.K.A. and R01AI059536, R56AI089547, R56AI093786, and
R21AI097568 to C.F.B.), a Midwest Regional Center of Excellence
Developmental Grant [U54AI057160-Virgin (PI) to G.K.A.], and the Welch
Foundation (I-1612 to J.M.R.). DoD Defense Threat Reduction Agency Grant
4.10011_07_RD_B to M. A. O. This study made use of the National Magnetic
Resonance Facility at Madison, which is supported by National Institutes
of Health grants P41RR02301 (Biomedical Research Technology Program,
National Center for Research Resources) and P41GM66326 (National
Institute of General Medical Sciences). Equipment in the facility was
purchased with funds from the University of Wisconsin, the National
Institutes of Health (P41GM66326, P41RR02301, RR02781, and RR08438), the
National Science Foundation (DMB-8415048, OIA-9977486, and BIR-9214394),
and the U.S. Department of Agriculture.
NR 43
TC 17
Z9 19
U1 1
U2 47
PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
PI LONDON
PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND
SN 0022-2836
EI 1089-8638
J9 J MOL BIOL
JI J. Mol. Biol.
PD MAY 15
PY 2014
VL 426
IS 10
BP 2045
EP 2058
DI 10.1016/j.jmb.2014.01.010
PG 14
WC Biochemistry & Molecular Biology
SC Biochemistry & Molecular Biology
GA AH7XP
UT WOS:000336349000003
PM 24495995
ER
PT J
AU Reisner, A
Chen, XX
Kumar, K
Reifman, J
AF Reisner, Andrew
Chen, Xiaoxiao
Kumar, Kamal
Reifman, Jaques
TI Prehospital Heart Rate and Blood Pressure Increase the Positive
Predictive Value of the Glasgow Coma Scale for High-Mortality Traumatic
Brain Injury
SO JOURNAL OF NEUROTRAUMA
LA English
DT Article
DE heart rate; prehospital; Glasgow Coma Scale; traumatic brain injury;
blood pressure
ID SCORING SYSTEM; FIELD TRIAGE; ALGORITHMS; INTUBATION; VICTIMS; SCORES;
IMPACT; AGE
AB We hypothesized that vital signs could be used to improve the association between a trauma patient's prehospital Glasgow Coma Scale (GCS) score and his or her clinical condition. Previously, abnormally low and high blood pressures have both been associated with higher mortality for patients with traumatic brain injury (TBI). We undertook a retrospective analysis of 1384 adult prehospital trauma patients. Vital-sign data were electronically archived and analyzed. We examined the relative risk of severe head Abbreviated Injury Scale (AIS) 5-6 as a function of the GCS, systolic blood pressure (SBP), heart rate (HR), and respiratory rate (RR). We created multi-variate logistic regression models and, using DeLong's test, compared their area under receiver operating characteristic curves (ROC AUCs) for three outcomes: head AIS 5-6, all-cause mortality, and either head AIS 5-6 or neurosurgical procedure. We found significant bimodal relationships between head AIS 5-6 versus SBP and HR, but not RR. When the GCS was <15, ROC AUCs were significantly higher for a multi-variate regression model (GCS, SBP, and HR) versus GCS alone. In particular, patients with abnormalities in all parameters (GCS, SBP, and HR) were significantly more likely to have high-mortality TBI versus those with abnormalities in GCS alone. This could be useful for mobilizing resources (e.g., neurosurgeons and operating rooms at the receiving hospital) and might enable new prehospital management protocols where therapies are selected based on TBI mortality risk.
C1 [Reisner, Andrew; Chen, Xiaoxiao; Kumar, Kamal; Reifman, Jaques] US Army, Biotechnol High Performance Comp Software Applica, Med Res & Mat Command, Telemed & Adv Technol Res Ctr, Ft Detrick, MD 21702 USA.
[Reisner, Andrew] Massachusetts Gen Hosp, Dept Emergency Med, Boston, MA 02114 USA.
RP Reifman, J (reprint author), US Army, Biotechnol HPC Inst, Med Res & Mat Command, MCMR TT, 504 Scott St, Ft Detrick, MD 21702 USA.
EM jaques.reifman.civ@mail.mil
OI Kumar, Kamal/0000-0002-9470-6682
FU Defense Health Program; Combat Casualty Care Research Area Directorate
of the U.S. Army Medical Research and Materiel Command (Fort Detrick,
MD)
FX This work was supported by the Defense Health Program and the Combat
Casualty Care Research Area Directorate of the U.S. Army Medical
Research and Materiel Command (Fort Detrick, MD). The authors thank
Christopher Jamieson for his support in formatting the manuscript and
Kathleen McGuire Gilbert for editing the manuscript.
NR 33
TC 2
Z9 3
U1 0
U2 3
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0897-7151
EI 1557-9042
J9 J NEUROTRAUM
JI J. Neurotrauma
PD MAY 15
PY 2014
VL 31
IS 10
BP 906
EP 913
DI 10.1089/neu.2013.3128
PG 8
WC Critical Care Medicine; Clinical Neurology; Neurosciences
SC General & Internal Medicine; Neurosciences & Neurology
GA AH1ES
UT WOS:000335863200003
PM 24372334
ER
EF