FN Thomson Reuters Web of Science™ VR 1.0 PT J AU Warner, CH Warner, CM Appenzeller, GN Hoge, CW AF Warner, Christopher H. Warner, Carolynn M. Appenzeller, George N. Hoge, Charles W. TI Identifying and Managing Posttraumatic Stress Disorder SO AMERICAN FAMILY PHYSICIAN LA English DT Article ID COGNITIVE PROCESSING THERAPY; PRIMARY-CARE; SYMPTOMS; VETERANS; TRIAL; PTSD; PHARMACOTHERAPY; RECOMMENDATIONS; RISPERIDONE; VICTIMS AB Posttraumatic stress disorder (PTSD) occurs in an estimated 8% of men and 20% of women who are exposed to traumatic events. PTSD is a trauma- and stress-related disorder associated with significant psychosocial morbidity, substance abuse, and other negative physical health outcomes. The hallmarks of PTSD include exposure to a traumatic event; reexperiencing the event or intrusion symptoms; avoidance of people, places, or things that serve as a reminder of the trauma; negative mood and thoughts associated with the trauma; and chronic hyperarousal symptoms. Self-report questionnaires can assist clinicians in identifying anxiety problems associated with traumatic events. For patients who meet criteria for PTSD, trauma-focused psychotherapy and pharmacotherapy improve symptoms. Benzodiazepines and atypical antipsychotics are not recommended because studies have shown that adverse effects outweigh potential health benefits. Primary care physicians should monitor patients with PTSD for comorbid conditions such as substance abuse, mood disorders, and suicidality, and should refer patients to behavioral health specialists and support groups when appropriate. (Am Fam Physician. 2013; 88 (12): 827-834. Copyright (C) 2013 American Academy of Family Physicians.) C1 [Warner, Christopher H.; Warner, Carolynn M.] US Army Med Dept Activ Alaska, Ft Wainwright, AK USA. [Appenzeller, George N.] Blanchfield Army Community Hosp, Fort Campbell, KY USA. [Hoge, Charles W.] Walter Reed Army Inst Res, Silver Spring, MD USA. RP Warner, CH (reprint author), US Army Med Dept Activ Alaska, Ft Wainwright, AK USA. EM Christopher.h.wamer.mil@mail.mil NR 39 TC 12 Z9 13 U1 1 U2 10 PU AMER ACAD FAMILY PHYSICIANS PI KANSAS CITY PA 8880 WARD PARKWAY, KANSAS CITY, MO 64114-2797 USA SN 0002-838X EI 1532-0650 J9 AM FAM PHYSICIAN JI Am. Fam. Physician PD DEC 15 PY 2013 VL 88 IS 12 BP 827 EP 834 PG 8 WC Primary Health Care; Medicine, General & Internal SC General & Internal Medicine GA 277DC UT WOS:000328797900005 PM 24364547 ER PT J AU Williams, JD Nguyen, ST Gu, S Ding, XY Butler, MM Tashjian, TF Opperman, TJ Panchal, RG Bavari, S Peet, NP Moir, DT Bowlin, TL AF Williams, John D. Nguyen, Son T. Gu, Shen Ding, Xiaoyuan Butler, Michelle M. Tashjian, Tommy F. Opperman, Timothy J. Panchal, Rekha G. Bavari, Sina Peet, Norton P. Moir, Donald T. Bowlin, Terry L. TI Potent and broad-spectrum antibacterial activity of indole-based bisamidine antibiotics: Synthesis and SAR of novel analogs of MBX 1066 and MBX 1090 SO BIOORGANIC & MEDICINAL CHEMISTRY LA English DT Article DE Antibiotic; Antibacterial; Broad-spectrum; Indole; Cadogan-Sundberg reaction; Reissert indole synthesis; McMurry reductive homocoupling reaction; Amidine; Imidazoline; Tetrahydropyrimidine ID INFECTIOUS-DISEASES SOCIETY; GRAM-NEGATIVE BACILLI; COUPLING REACTIONS; HYDROGENATION; RESISTANCE; CONVERSION; NITRILES; BACTERIA; TITANIUM; AMERICA AB The prevalence of drug-resistant bacteria in the clinic has propelled a concerted effort to find new classes of antibiotics that will circumvent current modes of resistance. We have previously described a set of bisamidine antibiotics that contains a core composed of two indoles and a central linker. The first compounds of the series, MBX 1066 and MBX 1090, have potent antibacterial properties against a wide range of Gram-positive and Gram-negative bacteria. We have conducted a systematic exploration of the amidine functionalities, the central linker, and substituents at the indole 3-position to determine the factors involved in potent antibacterial activity. Some of the newly synthesized compounds have even more potent and broad-spectrum activity than MBX 1066 and MBX 1090. (C) 2013 Elsevier Ltd. All rights reserved. C1 [Williams, John D.; Nguyen, Son T.; Gu, Shen; Ding, Xiaoyuan; Butler, Michelle M.; Tashjian, Tommy F.; Opperman, Timothy J.; Peet, Norton P.; Moir, Donald T.; Bowlin, Terry L.] Microbiotix Inc, Worcester, MA 01604 USA. [Panchal, Rekha G.; Bavari, Sina] US Army Med Res Inst Infect Dis, Frederick, MD 21702 USA. RP Williams, JD (reprint author), Microbiotix Inc, 1 Innovat Dr, Worcester, MA 01604 USA. EM jwilliams@microbiotix.com FU National Institute of Allergy and Infectious Disease of the National Institutes of Health [U01AI082052] FX Research reported in this article was generously supported by the National Institute of Allergy and Infectious Disease of the National Institutes of Health under award number U01AI082052. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. NR 48 TC 7 Z9 7 U1 0 U2 10 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0968-0896 EI 1464-3391 J9 BIOORGAN MED CHEM JI Bioorg. Med. Chem. PD DEC 15 PY 2013 VL 21 IS 24 BP 7790 EP 7806 DI 10.1016/j.bmc.2013.10.014 PG 17 WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Chemistry, Organic SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Chemistry GA 262VO UT WOS:000327766200026 PM 24239389 ER PT J AU Lowery, CA Adler, M Borrell, A Janda, KD AF Lowery, Colin A. Adler, Michael Borrell, Andrew Janda, Kim D. TI Scorpion toxins for the reversal of BoNT-induced paralysis SO BIOORGANIC & MEDICINAL CHEMISTRY LETTERS LA English DT Article DE Botulinum neurotoxin; Scorpion toxin; Bioterrorism; Aminopyridine; Phrenic nerve hemidiaphragm ID NERVE-HEMIDIAPHRAGM PREPARATIONS; ACTIVATED POTASSIUM CHANNELS; GATED K+ CHANNELS; STRUCTURAL-CHARACTERIZATION; MULTIPLE-SCLEROSIS; CHARYBDOTOXIN; VENOM; 3,4-DIAMINOPYRIDINE; AMINOPYRIDINES; PURIFICATION AB The botulinum neurotoxins, characterized by their neuromuscular paralytic effects, are the most toxic proteins known to man. Due to their extreme potency, ease of production, and duration of activity, the BoNT proteins have been classified by the Centers for Disease Control as high threat agents for bioterrorism. In an attempt to discover effective BoNT therapeutics, we have pursued a strategy in which we leverage the blockade of K+ channels that ultimately results in the reversal of neuromuscular paralysis. Towards this end, we utilized peptides derived from scorpion venom that are highly potent K+ channel blockers. Herein, we report the synthesis of charybdotoxin, a 37 amino acid peptide, and detail its activity, along with iberiotoxin and margatoxin, in a mouse phrenic nerve hemidiaphragm assay in the absence and the presence of BoNT/A. (C) 2013 Elsevier Ltd. All rights reserved. C1 [Lowery, Colin A.; Janda, Kim D.] Scripps Res Inst, Skaggs Inst Chem Biol, Dept Chem, La Jolla, CA 92037 USA. [Lowery, Colin A.; Janda, Kim D.] Scripps Res Inst, Skaggs Inst Chem Biol, Dept Immunol & Microbial Sci, La Jolla, CA 92037 USA. [Adler, Michael; Borrell, Andrew] US Army Med Res Inst Chem Def, Neurobehav Toxicol Branch, Analyt Toxicol Div, Aberdeen Proving Ground, MD 21010 USA. [Janda, Kim D.] Scripps Res Inst, WIRM, La Jolla, CA 92037 USA. RP Janda, KD (reprint author), Scripps Res Inst, Skaggs Inst Chem Biol, Dept Chem, 10550 North Torrey Pines Rd, La Jolla, CA 92037 USA. EM kdjanda@scripps.edu FU NIH [AI080671] FX We acknowledge the NIH for funding (AI080671) and Dr. Alexander Mayorov for insightful discussions. NR 39 TC 1 Z9 1 U1 0 U2 13 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0960-894X EI 1464-3405 J9 BIOORG MED CHEM LETT JI Bioorg. Med. Chem. Lett. PD DEC 15 PY 2013 VL 23 IS 24 BP 6743 EP 6746 DI 10.1016/j.bmcl.2013.10.029 PG 4 WC Chemistry, Medicinal; Chemistry, Organic SC Pharmacology & Pharmacy; Chemistry GA 263DU UT WOS:000327787700041 PM 24252544 ER PT J AU Sirk, TW Khare, KS Karim, M Lenhart, JL Andzelm, JW McKenna, GB Khare, R AF Sirk, Timothy W. Khare, Ketan S. Karim, Mir Lenhart, Joseph L. Andzelm, Jan W. McKenna, Gregory B. Khare, Rajesh TI High strain rate mechanical properties of a cross-linked epoxy across the glass transition SO POLYMER LA English DT Article DE Molecular simulation; Cross-linked epoxy; High strain rate mechanical properties ID MOLECULAR-DYNAMICS SIMULATIONS; VISCOELASTIC POISSONS RATIO; AMORPHOUS POLYMERS; THERMOMECHANICAL RESPONSE; EFFICIENT GENERATION; THERMOSET POLYMER; NETWORK STRUCTURE; AM1-BCC MODEL; FORCE-FIELD; BEHAVIOR AB Molecular dynamics simulations were used to study the high strain rate mechanical properties of a crosslinked epoxy system comprised of diglycidyl ether of bisphenol A (DGEBA) that is cross-linked by a poly(oxypropylene) diamine with three propylene oxide moieties per diamine. Atomistic network structures were characterized using volume-temperature behavior and their response to mechanical deformation. The Young's modulus was determined as a function of temperature across strain rates spanning three decades in magnitude, and collapsed onto a single "master curve" using the time -temperature superposition principle (TTSP). The master curve obtained from molecular dynamics simulation data shows good agreement with a similar master curve of the reduced storage modulus as a function of frequency, which was obtained using experiments. At higher strain rates, the simulation master curve deviated from the experimental master curve. This deviation could be attributed to the lack of occurrence of sub-T-g motions on the time scale of simulations due to the use of higher strain rates in simulations compared to experiments. Our work demonstrates the utility of TTSP in connecting the thermo-mechanical behavior of polymers at high strain rates and high temperatures to experiments performed at much different conditions. To the best of our knowledge, the use of the time temperature superposition to compare mechanical properties determined from molecular simulation and experiments is the first reported effort of its kind. Published by Elsevier Ltd. C1 [Sirk, Timothy W.; Lenhart, Joseph L.; Andzelm, Jan W.] US Army Res Lab, Macromol Sci & Technol Branch, Aberdeen, MD USA. [Khare, Ketan S.; Karim, Mir; McKenna, Gregory B.; Khare, Rajesh] Texas Tech Univ, Dept Chem Engn, Lubbock, TX 79409 USA. RP Andzelm, JW (reprint author), US Army Res Lab, Macromol Sci & Technol Branch, Aberdeen, MD USA. EM jan.w.andzelm.civ@mail.mil; rajesh.khare@ttu.edu RI Khare, Rajesh/J-2079-2014; Khare, Ketan/C-6074-2012; McKenna, Gregory/O-1134-2013 OI Khare, Rajesh/0000-0002-8859-766X; Khare, Ketan/0000-0002-5487-5553; McKenna, Gregory/0000-0002-5676-9930 FU U.S. Army Research Laboratory (USARL); U.S. Army/Battelle Memorial Institute [US001-0000287704]; John R. Bradford endowment at Texas Tech University FX TWS acknowledges partial support from an appointment to the Postgraduate Research Participation Program at the U.S. Army Research Laboratory (USARL) administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the U.S. Department of Energy and the USARL. The work of KSK, MK, and RK was supported by U.S. Army/Battelle Memorial Institute contract number US001-0000287704. GBM acknowledges partial support from the John R. Bradford endowment at Texas Tech University. The authors thank Mark Hindenlang for contributions to DMA experiments. NR 70 TC 25 Z9 25 U1 6 U2 79 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0032-3861 EI 1873-2291 J9 POLYMER JI Polymer PD DEC 13 PY 2013 VL 54 IS 26 BP 7048 EP 7057 DI 10.1016/j.polymer.2013.10.051 PG 10 WC Polymer Science SC Polymer Science GA 272BK UT WOS:000328435100023 ER PT J AU Martini, WZ Cortez, DS Dubick, MA AF Martini, Wenjun Z. Cortez, Douglas S. Dubick, Michael A. TI Comparisons of normal saline and lactated Ringer's resuscitation on hemodynamics, metabolic responses, and coagulation in pigs after severe hemorrhagic shock SO SCANDINAVIAN JOURNAL OF TRAUMA RESUSCITATION & EMERGENCY MEDICINE LA English DT Article DE Hemorrhagic shock; Oxygen metabolism; Coagulation; Pre-hospital resuscitation and Thromboelastrograph ID FLUID RESUSCITATION; INDEPENDENT CONTRIBUTIONS; RENAL-TRANSPLANTATION; SWINE; ACIDOSIS; HYPOTHERMIA; INJURY; COAGULOPATHY; HETASTARCH; MANAGEMENT AB Background: Ongoing improvements in trauma care now recommend earlier use of blood products as part of damage control resuscitation, but generally these products are not available at far forward battlefield locations. For the military, questions continue to arise regarding efficacy of normal saline (NS) vs. lactated Ringer's (LR). Thus, this study compared the effects of LR and NS after severe hemorrhage in pigs. Methods: 20 anesthetized pigs were randomized into control (n = 6), LR (n = 7), and NS (n = 7) groups. Hemorrhage of 60% estimated total blood volume was induced in LR and NS groups by removing blood from the left femoral artery using a computer-controlled pump. Afterwards, the pigs were resuscitated with either LR at 3 times the bled volume or the volume of NS to reach the same mean arterial pressure (MAP) as in LR group. Hemodynamics were measured hourly and blood samples were taken at baseline (BL), 15 min, 3 h and 6 h after resuscitation to measure changes in coagulation using thrombelastograph(R). Results: MAP was decreased by hemorrhage but returned to BL within 1 h after resuscitation with LR (119 +/- 7 ml/kg) or NS (183 +/- 9 ml/kg, p < 0.05). Base excess (BE) was decreased by hemorrhage; resuscitation with LR recovered BE but not with NS. Total peripheral resistance was decreased with NS and LR, with a larger drop shown in NS. Serum potassium was increased with NS, but not affected with LR. Coagulation changes were similar between LR and NS. Conclusions: NS may be inferior to LR in resuscitation due to its vasodilator effects and the risks of metabolic acidosis and hyperkalemia. C1 [Martini, Wenjun Z.; Cortez, Douglas S.; Dubick, Michael A.] US Army, Inst Surg Res, JBSA Ft, Houston, TX 78234 USA. RP Martini, WZ (reprint author), US Army, Inst Surg Res, JBSA Ft, 3698 Chambers Pass, Houston, TX 78234 USA. EM wenjun.z.martini.civ@mail.mil FU Veterinary Service Support Branch; Laboratory Support Branch at the U.S. Army Institute of Surgical Research; U.S. Army Medical Research and Materiel Command FX The authors appreciate the support received from the Veterinary Service Support Branch and Laboratory Support Branch at the U.S. Army Institute of Surgical Research.; This study was supported by the U.S. Army Medical Research and Materiel Command. The opinions or assertions contained herein are the private views of the author and are not to be construed as official or as reflecting the views of the Department of the Army or the Department of Defense. NR 39 TC 1 Z9 3 U1 1 U2 4 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1757-7241 J9 SCAND J TRAUMA RESUS JI Scand. J. Trauma Resusc. Emerg. Med. PD DEC 11 PY 2013 VL 21 AR 86 DI 10.1186/1757-7241-21-86 PG 12 WC Emergency Medicine SC Emergency Medicine GA 282OD UT WOS:000329180400001 PM 24330733 ER PT J AU Halsey, NA Griffioen, M Dreskin, SC Dekker, CL Wood, R Sharma, D Jones, JF LaRussa, PS Garner, J Berger, M Proveaux, T Vellozzi, C Broder, K Setse, R Pahud, B Hrncir, D Choi, H Sparks, R Williams, SE Engler, RJ Gidudu, J Baxter, R Klein, N Edwards, K Cano, M Kelso, JM AF Halsey, Neal A. Griffioen, Mari Dreskin, Stephen C. Dekker, Cornelia L. Wood, Robert Sharma, Devindra Jones, James F. LaRussa, Philip S. Garner, Jenny Berger, Melvin Proveaux, Tina Vellozzi, Claudia Broder, Karen Setse, Rosanna Pahud, Barbara Hrncir, David Choi, Howard Sparks, Robert Williams, Sarah Elizabeth Engler, Renata J. Gidudu, Jane Baxter, Roger Klein, Nicola Edwards, Kathryn Cano, Maria Kelso, John M. CA Hypersensitivity Working Grp Clin TI Immediate hypersensitivity reactions following monovalent 2009 pandemic influenza A (H1N1) vaccines: Reports to VAERS SO VACCINE LA English DT Article DE Immunization; Influenza vaccine; Hypersensitivity; Anaphylaxis; Urticaria; Allergic reactions; H1N1 influenza vaccine ID DUCK RUBELLA VACCINE; ADVERSE EVENTS; ANAPHYLAXIS; SAFETY; AGE; EMERGENCY; PROJECT; NETWORK AB Background: Hypersensitivity disorders following vaccinations are a cause for concern. Objective: To determine the type and rate by age, gender, and vaccine received for reported hypersensitivity reactions following monovalent 2009 pandemic influenza A (H1N1) vaccines. Design: A systematic review of reports to the Vaccine Adverse Event Reporting System (VAERS) following monovalent 2009 pandemic influenza A (H1N1) vaccines. Setting/patients: US Civilian reports following vaccine received from October 1, 2009 through May 31, 2010. Measurements: Age, gender, vaccines received, diagnoses, clinical signs, and treatment were reviewed by nurses and physicians with expertise in vaccine adverse events. A panel of experts, including seven allergists reviewed complex illnesses and those with conflicting evidence for classification of the event. Results: Of 1984 reports, 1286 were consistent with immediate hypersensitivity disorders and 698 were attributed to anxiety reactions, syncope, or other illnesses. The female-to-male ratio was >4:1 for persons 20-to-59 years of age, but approximately equal for children under 10. One hundred eleven reports met Brighton Collaboration criteria for anaphylaxis; only one-half received epinephrine for initial therapy. The overall rate of reported hypersensitivity reactions was 10.7 per million vaccine doses distributed, with a 2-fold higher rate for live vaccine. Limitations: Underreporting, especially of mild events, would result in an underestimate of the true rate of immediate hypersensitivity reactions. Selective reporting of events in adult females could have resulted in higher rates than reported for males. Conclusions: Adult females may be at higher risk of hypersensitivity reactions after influenza vaccination than men. Although the risk of hypersensitivity reactions following 2009 pandemic influenza A (H1N1) vaccines was low, all clinics administering vaccines should be familiar with treatment guidelines for these adverse events, including the use of intramuscular epinephrine early in the course of serious hypersensitivity reactions. (C) 2013 Elsevier Ltd. All rights reserved. C1 [Halsey, Neal A.; Griffioen, Mari; Garner, Jenny; Proveaux, Tina; Setse, Rosanna; Choi, Howard] Johns Hopkins Bloomberg Sch Publ Hlth, Inst Vaccine Safety, Baltimore, MD 21205 USA. [Dreskin, Stephen C.] Univ Colorado, Dept Med, Denver, CO USA. [Dekker, Cornelia L.] Stanford Univ, Sch Med, Dept Pediat, Stanford, CA 94305 USA. [Wood, Robert] Johns Hopkins Univ, Sch Med, Dept Pediat, Div Allergy & Immunol, Baltimore, MD 21205 USA. [Sharma, Devindra; Vellozzi, Claudia; Broder, Karen; Gidudu, Jane; Cano, Maria] Ctr Dis Control & Prevent, Immunizat Safety Off, Atlanta, GA USA. [Jones, James F.] Ctr Dis Control & Prevent, Chron Viral Dis Branch, Atlanta, GA USA. [LaRussa, Philip S.] Columbia Univ, Dept Pediat, Div Pediat Infect Dis, New York, NY 10027 USA. [Berger, Melvin] CSL Behring, King Of Prussia, PA USA. [Pahud, Barbara] Univ Missouri, Childrens Mercy Hosp & Clin, Kansas City, MO 64110 USA. [Hrncir, David; Engler, Renata J.] Walter Reed Natl Mil Med Ctr, US Army Publ Hlth Command, Mil Vaccine Agcy, Vaccine Healthcare Ctr Network, Bethesda, MD USA. [Sparks, Robert; Williams, Sarah Elizabeth; Edwards, Kathryn] Vanderbilt Univ, Sch Med, Nashville, TN 37212 USA. [Baxter, Roger; Klein, Nicola] Kaiser Permanente Vaccine Study Ctr, Oakland, CA USA. [Kelso, John M.] Scripps Clin, Div Allergy Asthma & Immunol, San Diego, CA USA. RP Halsey, NA (reprint author), Johns Hopkins Bloomberg Sch Publ Hlth, Inst Vaccine Safety, 615 N Wolfe St,Room W5041, Baltimore, MD 21205 USA. EM nhalsey@jhsph.edu RI Garner, Joseph/C-8422-2009 FU Clinical Immunization Safety Assessment Network; Centers for Disease Control and Prevention (CDC) [200-2002-00732] FX We thank Elaine Miller and Oidda Museru for their assistance in obtaining reports from the Vaccine Adverse Event Reporting System. This study was supported by the Clinical Immunization Safety Assessment Network and Vaccine Safety Datalink through a subcontract with America's Health Insurance Plans under contract 200-2002-00732 from the Centers for Disease Control and Prevention (CDC). NR 32 TC 9 Z9 9 U1 1 U2 7 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X EI 1873-2518 J9 VACCINE JI Vaccine PD DEC 9 PY 2013 VL 31 IS 51 BP 6107 EP 6112 DI 10.1016/j.vaccine.2013.09.066 PG 6 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 280EB UT WOS:000329010400012 PM 24120547 ER PT J AU Crowne, FJ Amani, M Birdwell, AG Chin, ML O'Regan, TP Najmaei, S Liu, Z Ajayan, PM Lou, J Dubey, M AF Crowne, Frank J. Amani, Matin Birdwell, A. Glen Chin, Matthew L. O'Regan, Terrance P. Najmaei, Sina Liu, Zheng Ajayan, Pulickel M. Lou, Jun Dubey, Madan TI Blueshift of the A-exciton peak in folded monolayer 1H-MoS2 SO PHYSICAL REVIEW B LA English DT Article ID LAYERED ELECTRON-GAS; SINGLE-LAYER; MOLYBDENUM-DISULFIDE; MOS2; CRYSTALS; PHOTOLUMINESCENCE; ELECTRODYNAMICS AB The large family of layered transition-metal dichalcogenides is widely believed to constitute a second family of two-dimensional (2D) semiconducting materials that can be used to create novel devices that complement those based on graphene. In many cases these materials have shown a transition from an indirect band gap in the bulk to a direct band gap in monolayer systems. In this work we experimentally show that folding a 1H molybdenum disulfide (MoS2) layer results in a turbostratic stack with enhanced photoluminescence quantum yield and a significant shift to the blue by similar to 90 meV. This is in contrast to the expected 2H-MoS2 band-structure characteristics, which include an indirect gap and quenched photoluminescence. We present a theoretical explanation for the origin of this behavior in terms of exciton screening. C1 [Crowne, Frank J.; Amani, Matin; Birdwell, A. Glen; Chin, Matthew L.; O'Regan, Terrance P.; Dubey, Madan] US Army, Res Lab, Sensors & Elect Devices Directorate, Adelphi, MD 20783 USA. [Najmaei, Sina; Ajayan, Pulickel M.; Lou, Jun] Rice Univ, Dept Mech Engn & Mat Sci, Houston, TX 77005 USA. [Liu, Zheng] Nanyang Technol Univ, Sch Elect & Elect Engn, Sch Mat Sci & Engn, Singapore 639798, Singapore. RP Crowne, FJ (reprint author), US Army, Res Lab, Sensors & Elect Devices Directorate, Adelphi, MD 20783 USA. EM frank.j.crowne2.civ@mail.mil FU US Army Research Laboratory (ARL) Director's Strategic Initiative (DSI) program on interfaces in stacked 2D atomic layered materials; ARO MURI program on 2D materials; Welch Foundation [C-1716]; NSF [ECCS-1327093]; Singapore National Research Foundation under NRF RF Award [NRF-RF2013-08] FX The authors acknowledge the support of the US Army Research Laboratory (ARL) Director's Strategic Initiative (DSI) program on interfaces in stacked 2D atomic layered materials. The authors would also like to thank Pani Varanasi, ARO, for his in-depth technical discussion on 2D atomic layer R&D. P. M. A., J.L., S.N., and Z.L. also acknowledge funding support from the ARO MURI program on 2D materials. S.N. and Z.L. acknowledge funding support from Welch Foundation Grant C-1716 and the NSF Grant ECCS-1327093. Z.L. also acknowledges funding support in part by the Singapore National Research Foundation under NRF RF Award No. NRF-RF2013-08. The views and conclusions contained in this document are those of the authors and should not be interpreted as representing the official policies, either expressed or implied, of the ARL or the US Government. The US Government is authorized to reproduce or distribute reprints for Government purposes notwithstanding any copyright notation herein. NR 29 TC 12 Z9 12 U1 4 U2 65 PU AMER PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 1098-0121 EI 1550-235X J9 PHYS REV B JI Phys. Rev. B PD DEC 6 PY 2013 VL 88 IS 23 AR 235302 DI 10.1103/PhysRevB.88.235302 PG 7 WC Physics, Condensed Matter SC Physics GA 274BB UT WOS:000328579000002 ER PT J AU Koontz, MB Koontz, JM Pezeshki, SR Moore, M AF Koontz, Melissa B. Koontz, Joshua M. Pezeshki, S. R. Moore, Matthew TI NUTRIENT AND GROWTH RESPONSES OF LEERSIA ORYZOIDES, RICE CUTGRASS, TO VARYING DEGREES OF SOIL SATURATION AND WATER NITROGEN CONCENTRATION SO JOURNAL OF PLANT NUTRITION LA English DT Article DE agricultural runoff; elemental concentrations; drainage ditch; N pollution; variable flooding; wetland plants; vegetated buffer; buffer strip ID AGRICULTURAL DRAINAGE DITCH; FINE-ROOT DYNAMICS; MISSISSIPPI DELTA; METABOLISM; OXYGEN; AVAILABILITY; ACCLIMATION; DEMOGRAPHY; WETLANDS; RUNOFF AB Leersia oryzoides (rice cutgrass) is an obligate wetland plant common to agricultural drainage ditches. The objective of this greenhouse study was to expose plants to various flooding and aqueous nitrogen (N) concentrations and then to quantify the allocation of nutrients and biomass to plant components. Plants in the continuously flooded treatment (CF) had the highest tissue concentrations of copper (Cu), sulfur (S), zinc (Zn), potassium (K), sodium (Na), and manganese (Mn) in one or more plant components. Plants in the partially flooded treatment (PF) had the highest concentrations of magnesium (Mg) in leaves. The N input affected phosphorus (P) and S concentrations in roots. Leaf, stem, and root biomass were highest in PF plants. Rhizome biomass was the lowest in CF plants. These results indicate that L. oryzoides may significantly affect elemental concentrations in surface waters by its ability to uptake various elements and subsequent sequestration in various biomass components. C1 [Koontz, Melissa B.; Pezeshki, S. R.] Univ Memphis, Memphis, TN 38152 USA. [Koontz, Joshua M.] US Army Corps Engineers, Environm Div, Memphis, TN USA. [Moore, Matthew] USDA ARS, Natl Sedimentat Lab, Water Qual & Ecol Res Unit, Oxford, MS 38655 USA. RP Koontz, MB (reprint author), Univ Memphis, 3774 Walker Ave, Memphis, TN 38152 USA. EM mlee1@memphis.edu NR 52 TC 0 Z9 0 U1 4 U2 30 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA SN 0190-4167 EI 1532-4087 J9 J PLANT NUTR JI J. Plant Nutr. PD DEC 6 PY 2013 VL 36 IS 14 BP 2236 EP 2258 DI 10.1080/01904167.2013.837920 PG 23 WC Plant Sciences SC Plant Sciences GA 240BQ UT WOS:000326070100009 ER PT J AU Perkins, MW Wong, B Rodriguez, A Devorak, JL Alves, DA Murphy, G Sciuto, AM AF Perkins, Michael W. Wong, Benjamin Rodriguez, Ashley Devorak, Jennifer L. Alves, Derron A. Murphy, Gleeson Sciuto, Alfred M. TI Inhalation toxicity of soman vapor in non-anesthetized rats: A preliminary assessment of inhaled bronchodilator or steroid therapy SO CHEMICO-BIOLOGICAL INTERACTIONS LA English DT Article DE Soman; Inhalation exposure; Chemical warfare nerve agents; Respiratory toxicity; Cholinesterases; Bronchodilators ID OBSTRUCTIVE PULMONARY-DISEASE; RESPIRATORY-DISTRESS-SYNDROME; METERED-DOSE INHALER; INDUCED SEIZURES; NASAL CAVITY; LUNG INJURY; GUINEA-PIG; ACETYLCHOLINESTERASE; EXPOSURE; INTOXICATION AB Respiratory toxicity, injury and treatment following vapor inhalational exposure to the chemical warfare nerve agent (CWNA) soman (GD) were examined in non-anesthetized rats. This study exposed male Sprague-Dawley rats (250-300 g) to 520, 560, 600, 825 or 1410 mg x min/m(3) of soman in a customized head-out inhalation system. Signs of CWNA-induced cholinergic crises were observed in all soman-exposed animals. The LCt50 of vaporized soman as determined by probit analysis was 593.1 mg x min/m(3). All animals exposed to 825 and 1410 mg x min/m(3) developed severe convulsions and died within 4-8 min post-exposure. Edema measured by wet/dry weight ratio of the left lung lobe increased in a dose-dependent manner in all soman-exposed animals. Bronchoalveolar lavage (BAL) fluid and blood acetylcholinesterase (AChE) activities were inhibited dose-dependently in soman-exposed groups at 24 h. A significant increase in total BAL protein was observed in soman-exposed animals at all doses. AChE activity was inhibited in lung and whole brain tissues in all soman-exposed animals. Histopathological analysis of the lungs of animals exposed to 600 mg x min/m(3) of soman revealed prominent morphological changes including alveolar histiocytosis, hemorrhage and inflammation consisting of neutrophilic exudate. Exposure of animals to 600 mg x min/m(3) of soman followed by treatment with two actuations for 10 s of Combivent (21 mu g of ipratropium bromide and 120 mu g of albuterol sulfate) and Symbicort (80 mu g budesonide and 4.5 mu g formoterol) by inhalation into a modified metered dose inhaler (MDI) 10 min post-exposure resulted in increased minute volume, but did not decrease mortality. These results indicate that inhalation exposure to soman vapor causes acute respiratory toxicity and injury in untreated, un-anesthetized rats and that inhalation treatment with Combivent or Symbicort did improve the respiratory outcomes, but did not influence lethality. Published by Elsevier Ireland Ltd. C1 [Perkins, Michael W.; Wong, Benjamin; Rodriguez, Ashley; Devorak, Jennifer L.; Alves, Derron A.; Murphy, Gleeson; Sciuto, Alfred M.] US Army Med Res Inst Chem Def, Analyt Toxicol Div, Med Toxicol Branch, Aberdeen Proving Ground, MD 21010 USA. RP Sciuto, AM (reprint author), US Army Med Res Inst Chem Def, Analyt Toxicol Div, 3100 Ricketts Point Rd, Aberdeen Proving Ground, MD 21010 USA. EM alfred.mario.sciuto@us.army.mil FU Defense Threat Reduction Agency [3.F0014_09_RC_C] FX The project described was supported by Defense Threat Reduction Agency [3.F0014_09_RC_C]. NR 40 TC 4 Z9 4 U1 0 U2 142 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0009-2797 EI 1872-7786 J9 CHEM-BIOL INTERACT JI Chem.-Biol. Interact. PD DEC 5 PY 2013 VL 206 IS 3 SI SI BP 452 EP 461 DI 10.1016/j.cbi.2013.07.009 PG 10 WC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology GA 280HO UT WOS:000329019500005 PM 23886498 ER PT J AU Graham, JS Schoneboom, BA AF Graham, John S. Schoneboom, Bruce A. TI Historical perspective on effects and treatment of sulfur mustard injuries SO CHEMICO-BIOLOGICAL INTERACTIONS LA English DT Article DE Sulfur mustard; Skin; Lung; Eyes; Clinical signs and symptoms; Treatments ID CHRONIC SKIN-LESIONS; INDUCED CHRONIC PRURITUS; GAS EXPOSED PATIENTS; IRANIAN VETERANS; CHEMICAL WARFARE; CUTANEOUS COMPLICATIONS; WORLD-WAR-1 VETERANS; BETAMETHASONE CREAM; NITROGEN-MUSTARD; CLINICAL-TRIAL AB Sulfur mustard (2,2'-dichlorodiethyl sulfide; SM) is a potent vesicating chemical warfare agent that poses a continuing threat to both military and civilian populations. Significant SM injuries can take several months to heal, necessitate lengthy hospitalizations, and result in long-term complications affecting the skin, eyes, and lungs. This report summarizes initial and ongoing (chronic) clinical findings from SM casualties from the Iran-Iraq War (1980-1988), with an emphasis on cutaneous injury. In addition, we describe the cutaneous manifestations and treatment of several men recently and accidentally exposed to SM in the United States. Common, chronic cutaneous problems being reported in the Iranian casualties include pruritis (the primary complaint), burning, pain, redness, desquamation, hyperpigmentation, hypopigmentation, erythematous papular rash, xerosis, multiple cherry angiomas, atrophy, dermal scarring, hypertrophy, and sensitivity to mechanical injury with recurrent blistering and ulceration. Chronic ocular problems include keratitis, photophobia, persistent tearing, sensation of foreign body, corneal thinning and ulceration, vasculitis of the cornea and conjunctiva, and limbal stem cell deficiency. Chronic pulmonary problems include decreases in lung function, bronchitis with hyper-reactive airways, bronchiolitis, bronchiectasis, stenosis of the trachea and other large airways, emphysema, pulmonary fibrosis, decreased total lung capacity, and increased incidences of lung cancer, pulmonary infections, and tuberculosis. There are currently no standardized or optimized methods of casualty management; current treatment strategy consists of symptomatic management and is designed to relieve symptoms, prevent infections, and promote healing. New strategies are needed to provide for optimal and rapid healing, with the goals of (a) returning damaged tissue to optimal appearance and normal function in the shortest period of time, and (b) ameliorating chronic effects. Further experimental research and clinical trials will be needed to prevent or mitigate the acute clinical effects of SM exposure and to reduce or eliminate the long-term manifestations. Published by Elsevier Ireland Ltd. C1 [Graham, John S.; Schoneboom, Bruce A.] US Army, Off Commander, Med Res Inst Chem Def, Aberdeen Proving Ground, MD 21010 USA. RP Graham, JS (reprint author), US Army, Off Commander, Med Res Inst Chem Def, 3100 Ricketts Point Rd, Aberdeen Proving Ground, MD 21010 USA. EM john.s.graham1.civ@mail.mil FU Department of the Army; Defense Threat Reduction Agency - Joint Science and Technology Office, Medical ST Division FX Preparation of this article was supported financially by the Department of the Army and the Defense Threat Reduction Agency - Joint Science and Technology Office, Medical S&T Division. NR 79 TC 16 Z9 17 U1 6 U2 145 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0009-2797 EI 1872-7786 J9 CHEM-BIOL INTERACT JI Chem.-Biol. Interact. PD DEC 5 PY 2013 VL 206 IS 3 SI SI BP 512 EP 522 DI 10.1016/j.cbi.2013.06.013 PG 11 WC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology GA 280HO UT WOS:000329019500012 PM 23816402 ER PT J AU Sampath, AV Rodak, LE Chen, Y Zhou, Q Campbell, JC Shen, H Wraback, M AF Sampath, A. V. Rodak, L. E. Chen, Y. Zhou, Q. Campbell, J. C. Shen, H. Wraback, M. TI High quantum efficiency deep ultraviolet 4H-SIC photodetectors SO ELECTRONICS LETTERS LA English DT Article DE photodetectors; silicon compounds; ultraviolet detectors; wide band gap semiconductors; quantum efficiency; deep ultraviolet 4H-SiC photodetectors; SiC; wavelength 200 nm to 235 nm; depletion region; absorption; deep ultraviolet photons; carrier collection; deep ultraviolet spectrum; 4H-SiC p-n(a')-metal photodetectors ID VISIBLE-BLIND AB 4H-SiC p-n(-)-metal photodetectors are demonstrated having high external quantum efficiency >approximate to 40% in the deep ultraviolet spectrum between 200 and 235 nm. This improvement is attributed to the improved collection of carriers generated by deep ultraviolet photons through absorption in the depletion region of the detector. C1 [Sampath, A. V.; Rodak, L. E.; Shen, H.; Wraback, M.] US Army, Res Lab, Sensors & Electron Devices Directorate, RDRL SEE M, Adelphi, MD USA. [Chen, Y.; Zhou, Q.; Campbell, J. C.] Univ Virginia, Dept Elect & Comp Engn, Charlottesville, VA 22903 USA. RP Sampath, AV (reprint author), US Army, Res Lab, Sensors & Electron Devices Directorate, RDRL SEE M, 2800 Powder Mill Rd, Adelphi, MD USA. EM anand.v.sampath.civ@mail.mil NR 8 TC 1 Z9 1 U1 1 U2 17 PU INST ENGINEERING TECHNOLOGY-IET PI HERTFORD PA MICHAEL FARADAY HOUSE SIX HILLS WAY STEVENAGE, HERTFORD SG1 2AY, ENGLAND SN 0013-5194 EI 1350-911X J9 ELECTRON LETT JI Electron. Lett. PD DEC 5 PY 2013 VL 49 IS 25 BP 1629 EP 1630 DI 10.1049/el.2013.2889 PG 2 WC Engineering, Electrical & Electronic SC Engineering GA 262DO UT WOS:000327714500029 ER PT J AU Folkes, PA Olver, K AF Folkes, P. A. Olver, K. TI Space-charge limited current in the series resistance of GaAs solar cells SO JOURNAL OF PHYSICS D-APPLIED PHYSICS LA English DT Article ID INSULATOR; FILMS AB We report the observation of space-charge limited current in the current-voltage characteristics of GaAs solar cells as evidenced by an abrupt decrease in the series resistance, a concurrent steep increase in the dark current at a threshold voltage and the observation of a quadratic dependence of the dark current on the voltage across the series resistance above threshold. The abrupt decrease in the series resistance at threshold, results in the observation of negative differential resistance and a subsequent hysteresis in the current-voltage characteristics. Auger electron spectroscopy analysis shows that the space-charge limited current can be attributed to a thin insulating CrAs layer at the contact/semiconductor interface. C1 [Folkes, P. A.; Olver, K.] Army Res Lab, Adelphi, MD 20783 USA. RP Folkes, PA (reprint author), Army Res Lab, Adelphi, MD 20783 USA. NR 17 TC 0 Z9 0 U1 1 U2 19 PU IOP PUBLISHING LTD PI BRISTOL PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND SN 0022-3727 EI 1361-6463 J9 J PHYS D APPL PHYS JI J. Phys. D-Appl. Phys. PD DEC 4 PY 2013 VL 46 IS 48 AR 485102 DI 10.1088/0022-3727/46/48/485102 PG 5 WC Physics, Applied SC Physics GA 259PT UT WOS:000327539500008 ER PT J AU Liu, J Tawa, GJ Wallqvist, A AF Liu, Jin Tawa, Gregory J. Wallqvist, Anders TI Identifying Cytochrome P450 Functional Networks and Their Allosteric Regulatory Elements SO PLOS ONE LA English DT Article ID MICROSOMAL CYTOCHROME-P450; ORGANIC-MOLECULES; CRYSTAL-STRUCTURE; BINDING SITE; 3A4; PROTEIN; SUBSTRATE; RESIDUES; MONOOXYGENASE; ADAPTATIONS AB Cytochrome P450 (CYP) enzymes play key roles in drug metabolism and adverse drug-drug interactions. Despite tremendous efforts in the past decades, essential questions regarding the function and activity of CYPs remain unanswered. Here, we used a combination of sequence-based co-evolutionary analysis and structure-based anisotropic thermal diffusion (ATD) molecular dynamics simulations to detect allosteric networks of amino acid residues and characterize their biological and molecular functions. We investigated four CYP subfamilies (CYP1A, CYP2D, CYP2C, and CYP3A) that are involved in 90% of all metabolic drug transformations and identified four amino acid interaction networks associated with specific CYP functionalities, i.e., membrane binding, heme binding, catalytic activity, and dimerization. Interestingly, we did not detect any co-evolved substrate-binding network, suggesting that substrate recognition is specific for each subfamily. Analysis of the membrane binding networks revealed that different CYP proteins adopt different membrane-bound orientations, consistent with the differing substrate preference for each isoform. The catalytic networks were associated with conservation of catalytic function among CYP isoforms, whereas the dimerization network was specific to different CYP isoforms. We further applied low-temperature ATD simulations to verify proposed allosteric sites associated with the heme-binding network and their role in regulating metabolic fate. Our approach allowed for a broad characterization of CYP properties, such as membrane interactions, catalytic mechanisms, dimerization, and linking these to groups of residues that can serve as allosteric regulators. The presented combined co-evolutionary analysis and ATD simulation approach is also generally applicable to other biological systems where allostery plays a role. C1 [Liu, Jin; Tawa, Gregory J.; Wallqvist, Anders] US Army Med Res & Mat Command, Dept Def Biotechnol, High Performance Comp Software Applicat Inst, Telemed & Adv Technol Res Ctr, Ft Detrick, MD USA. RP Liu, J (reprint author), US Army Med Res & Mat Command, Dept Def Biotechnol, High Performance Comp Software Applicat Inst, Telemed & Adv Technol Res Ctr, Ft Detrick, MD USA. EM jliu@bhsai.org OI wallqvist, anders/0000-0002-9775-7469 FU U.S. Department of Defense Threat Reduction Agency [TMTI0004_09_BH_T] FX Funding of this research was provided by the U.S. Department of Defense Threat Reduction Agency Grant TMTI0004_09_BH_T. The opinions and assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the US Army or the US Department of Defense. This paper has been approved for public release with unlimited distribution. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 49 TC 15 Z9 15 U1 1 U2 23 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD DEC 3 PY 2013 VL 8 IS 12 AR UNSP e81980 DI 10.1371/journal.pone.0081980 PG 11 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 265JR UT WOS:000327947800077 PM 24312617 ER PT J AU Bologna, M West, BJ Grigolini, P AF Bologna, Mauro West, Bruce J. Grigolini, Paolo TI Renewal and memory origin of anomalous diffusion: A discussion of their joint action SO PHYSICAL REVIEW E LA English DT Article ID STRANGE KINETICS; MOTIONS AB The adoption of the formalism of fractional calculus is an elegant way to simulate either subdiffusion or superdiffusion from within a renewal perspective where the occurrence of an event at a given time t does not have any memory of the events occurring at earlier times. We illustrate a physical model to assign infinite memory to renewal anomalous diffusion and we find ( i) a condition where the simultaneous action of a renewal and a memory source of subdiffusion generates localization and ( ii) a condition where they make subdiffusion weaker and superdiffusion emerge. We argue that our approach may provide important contributions to the current search to distinguish the renewal from the memory source of subdiffusion. C1 [Bologna, Mauro] Univ Tarapaca, Inst Alta Invest, Tarapaca, Chile. [West, Bruce J.] Army Res Off, Informat Sci Directorate, Res Triangle Pk, NC 27709 USA. [Grigolini, Paolo] Univ N Texas, Ctr Nonlinear Sci, Denton, TX 76203 USA. RP Bologna, M (reprint author), Univ Tarapaca, Inst Alta Invest, Casilla 6-D Arica, Tarapaca, Chile. EM mauroh69@gmail.com; bruce.j.west.civ@mail.mil; grigo@unt.edu FU FONDECYT Project [1110231]; ARO [W911NF-11-1-0478]; Welch [B-1577] FX M.B. acknowledges financial support from FONDECYT Project No. 1110231. P.G. warmly thanks ARO and Welch for their support through Grants No. W911NF-11-1-0478 and No. B-1577, respectively. NR 22 TC 6 Z9 6 U1 1 U2 4 PU AMER PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 2470-0045 EI 2470-0053 J9 PHYS REV E JI Phys. Rev. E PD DEC 2 PY 2013 VL 88 IS 6 AR UNSP 062106 DI 10.1103/PhysRevE.88.062106 PG 7 WC Physics, Fluids & Plasmas; Physics, Mathematical SC Physics GA 274KK UT WOS:000328605000007 PM 24483385 ER PT J AU Vincenti, MA de Ceglia, D Scalora, M AF Vincenti, M. A. de Ceglia, D. Scalora, M. TI Nonlinear dynamics in low permittivity media: the impact of losses SO OPTICS EXPRESS LA English DT Article ID SUBWAVELENGTH METAL APERTURES; 2ND-HARMONIC GENERATION; ARRAYS; RADIATION; FILM AB Slabs of materials with near-zero permittivity display enhanced nonlinear processes. We show that field enhancement due to the continuity of the longitudinal component of the displacement field drastically enhances harmonic generation. We investigate the impact of losses with and without bulk nonlinearities and demonstrate that in the latter scenario surface, magnetic and quadrupolar nonlinear sources cannot always be ignored. (C) 2013 The Optical Society of America C1 [Vincenti, M. A.; de Ceglia, D.] Natl Res Council AMRDEC, Charles M Bowden Res Lab, Redstone Arsenal, AL 35898 USA. [Scalora, M.] US Army RDECOM, Charles M Bowden Res Lab, AMRDEC, Redstone Arsenal, AL 35898 USA. RP Vincenti, MA (reprint author), Natl Res Council AMRDEC, Charles M Bowden Res Lab, Redstone Arsenal, AL 35898 USA. EM maria.vincenti@us.army.mil FU US Army - AMRDEC FX This research was performed while the authors M. A. Vincenti and D. de Ceglia held a National Research Council Research Associateship awards at US Army - AMRDEC. NR 28 TC 4 Z9 4 U1 3 U2 13 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1094-4087 J9 OPT EXPRESS JI Opt. Express PD DEC 2 PY 2013 VL 21 IS 24 BP 29949 EP 29954 DI 10.1364/OE.21.029949 PG 6 WC Optics SC Optics GA 265JP UT WOS:000327947500088 PM 24514546 ER PT J AU Sanchez, JL Agan, BK Tsai, AY Macalino, GE Wurapa, E Mbuchi, M Dueger, E Horton, KC Montano-Torres, SM Tilley, DH Saylors, KE Puplampu, N Duplessis, CC Harrison, DJ Putnam, SD Garges, EC Espinosa, BJ Dejli, J Meyers, M Yingst, SL Jerse, AE Maktabi, HH Burke, RL Jordan, NN Nowak, G Hsu, K Soge, OO Holmes, KK McClelland, RS MacDonald, MR Payin, JA Gaydos, JC Tramont, EC AF Sanchez, Jose L. Agan, Brian K. Tsai, Alice Y. Macalino, Grace E. Wurapa, Eyako Mbuchi, Margaret Dueger, Erica Horton, Katherine C. Montano-Torres, Silvia M. Tilley, Drake H. Saylors, Karen E. Puplampu, Naiki Duplessis, Christopher C. Harrison, Dustin J. Putnam, Shannon D. Garges, Eric C. Espinosa, Benjamin J. Dejli, Jamal Meyers, Mitchell Yingst, Samuel L. Jerse, Ann E. Maktabi, Hala H. Burke, Ronald L. Jordan, Nikki N. Nowak, Gosia Hsu, Katherine Soge, Olusegun O. Holmes, King K. McClelland, R. Scott MacDonald, Michael R. Payin, Julie A. Gaydos, Joel C. Tramont, Edmund C. TI Expanded Sexually Transmitted Infection Surveillance Efforts in the United States Military: A Time for Action SO MILITARY MEDICINE LA English DT Editorial Material ID RESISTANT NEISSERIA-GONORRHOEAE; DISEASES-TREATMENT-GUIDELINES; SIMPLEX-VIRUS TYPE-2; GONOCOCCAL INFECTIONS; QUADRIVALENT VACCINE; HUMAN-PAPILLOMAVIRUS; HIV-INFECTION; NO LONGER; CHLAMYDIA; ARMY C1 [Sanchez, Jose L.; Tsai, Alice Y.; Maktabi, Hala H.; Burke, Ronald L.; Gaydos, Joel C.] Armed Forces Hlth Surveillance Ctr, Silver Spring, MD 20904 USA. [Sanchez, Jose L.; Payin, Julie A.; Gaydos, Joel C.] Henry M Jackson Fdn Adv Mil Med, Silver Spring, MD 20904 USA. [Agan, Brian K.; Macalino, Grace E.] Uniformed Serv Univ Hlth Sci USU, Bethesda, MD 20814 USA. [Wurapa, Eyako; Mbuchi, Margaret] US Embassy, US Army Med Res Unit Kenya, Nairobi 00621, Kenya. [Dueger, Erica; Horton, Katherine C.] US Ctr Dis Control & Prevent, US Naval Med Res Unit 3, Cairo, Egypt. [Dueger, Erica; Horton, Katherine C.] US Ctr Dis Control & Prevent, GDDRC, Cairo, Egypt. [Montano-Torres, Silvia M.; Tilley, Drake H.] Ctr Med Naval CMST, US Naval Med Res Unit Peru 6, Lima, Peru. [Saylors, Karen E.] Global Viral & Metabiota, San Francisco, CA 94104 USA. [Puplampu, Naiki; Duplessis, Christopher C.] US Naval Med Res Unit 3 Detachment, Legon, Ghana. [Puplampu, Naiki; Duplessis, Christopher C.] Univ Ghana, Noguchi Mem Inst Med Res, Legon, Ghana. [Harrison, Dustin J.] US Naval Med Res Unit 2, JBPHH, Honolulu, HI 96860 USA. [Putnam, Shannon D.] US Naval Hlth Res Ctr, San Diego, CA 92106 USA. [Garges, Eric C.] Walter Reed Army Inst Res, Prevent Med Branch, Silver Spring, MD 20910 USA. [Espinosa, Benjamin J.] US Naval Med Res Ctr, Biol Def Res Directorate, Ft Detrick, MD 21702 USA. [Dejli, Jamal] US Naval Environm & Prevent Med Unit 2, Norfolk, VA 23511 USA. [Meyers, Mitchell; Yingst, Samuel L.] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Jerse, Ann E.] Uniformed Serv Univ Hlth Sci USC, Bethesda, MD 20814 USA. [Jordan, Nikki N.] USAPHC, Dis Epidemiol Program, Aberdeen Proving Ground, MD 21010 USA. [Jordan, Nikki N.] Army Inst Publ Hlth, Aberdeen Proving Ground, MD 21010 USA. [Nowak, Gosia] US Navy & Marine Corps Public Hlth Ctr NMCPHC, EpiData Ctr, Portsmouth, VA 23708 USA. [Hsu, Katherine] Massachusetts Dept Publ Hlth, Div STD Prevent & HIV AIDS Surveillance, Boston, MA 02130 USA. [Soge, Olusegun O.; Holmes, King K.; McClelland, R. Scott] Univ Washington, Harborview Med Ctr, Dept Global Hlth, Seattle, WA 98104 USA. [Soge, Olusegun O.; Holmes, King K.; McClelland, R. Scott] Univ Washington, Harborview Med Ctr, Dept Med, Seattle, WA 98104 USA. [MacDonald, Michael R.] Navy & Marine Corps Public Hlth Ctr, Sexual Hlth & Responsibil Program, Portsmouth, VA 23708 USA. [Tramont, Edmund C.] NIAID, Div Clin Res, NIH, Rockville, MD 20852 USA. RP Sanchez, JL (reprint author), Armed Forces Hlth Surveillance Ctr, 11800 Tech Rd,Suite 220, Silver Spring, MD 20904 USA. OI Agan, Brian/0000-0002-5114-1669 NR 58 TC 0 Z9 1 U1 0 U2 5 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD DEC PY 2013 VL 178 IS 12 BP 1271 EP 1280 DI 10.7205/MILMED-D-13-00137 PG 10 WC Medicine, General & Internal SC General & Internal Medicine GA AN7UF UT WOS:000340805800001 PM 24306007 ER PT J AU Hawk, AJ AF Hawk, Alan J. TI Medical Museum, 2nd Surgical Hospital SO MILITARY MEDICINE LA English DT Editorial Material AB When his unit, the 2nd Surgical Hospital (MA), was established at An Khe in January 1966, MAJ Rich began collecting retrieved foreign bodies along with documentation of the wound. A museum displaying these objects was established at one end of the operating room Quonset hut. During Rich's tour of duty, there were 324 cases where the patient was wounded by a punji stick, representing 38% wounds because of hostile action. C1 US Army Med Res & Mat Command, Natl Museum Hlth & Med, Silver Spring, MD 20910 USA. RP Hawk, AJ (reprint author), US Army Med Res & Mat Command, Natl Museum Hlth & Med, 2500 Linden Lane, Silver Spring, MD 20910 USA. NR 4 TC 0 Z9 0 U1 0 U2 1 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD DEC PY 2013 VL 178 IS 12 BP 1373 EP 1373 DI 10.7205/MILMED-D-13-00294 PG 1 WC Medicine, General & Internal SC General & Internal Medicine GA AN7UF UT WOS:000340805800016 PM 24306022 ER PT J AU Allison, PG Hammi, Y Jordon, JB Horstemeyer, MF AF Allison, P. G. Hammi, Y. Jordon, J. B. Horstemeyer, M. F. TI Modelling and experimental study of fatigue of powder metal steel (FC-0205) SO POWDER METALLURGY LA English DT Article; Proceedings Paper CT Conference on Euro PM CY SEP 16-19, 2012 CL Basel, SWITZERLAND SP EPMA DE Automotive components/engineering; Fatigue modelling; Fractography; Steel; Strain control ID CRACK-GROWTH; ALUMINUM-ALLOY; MAGNESIUM ALLOY; CAST A356-T6; BEHAVIOR; MICROSTRUCTURE; POROSITY; TEMPERATURE; PREDICTION; INITIATION AB The microstructure sensitive multistage fatigue model captured the fatigue life of a powder metal FC-0205 steel alloy. Uniaxial strain controlled fatigue data and microstructure information from sets of high and low porosity specimens calibrated the model. Strain-life behaviour depicted that above the plastic strain limit of 0.002 mm mm(-1) in the low cycle fatigue regime, where ubiquitous plasticity occurred, the different porosity levels gave distinct, visibly different results. However, specimens tested below the plastic limit in the high cycle fatigue regime, where failure was dominated by local cyclic microplasticity, showed unclear fatigue lives at different porosity levels. Fractography using scanning electron microscopy showed no clear presence of striations; however, asserted striations in powder metal specimens were similar to geometrical features observed on fracture surfaces of monotonically loaded specimens. The experimental and microstructure data calibrated a fatigue model that allowed for satisfactory prediction of the varying porosity specimen strain-life curves. C1 [Allison, P. G.] US Army ERDC, Vicksburg, MS 39180 USA. [Hammi, Y.] Mississippi State Univ, Ctr Adv Vehicular Syst, Mississippi State, MS 39762 USA. [Jordon, J. B.] Univ Alabama, Dept Mech Engn, Tuscaloosa, AL 35487 USA. [Horstemeyer, M. F.] Mississippi State Univ, Dept Mech Engn, Mississippi State, MS 39762 USA. RP Allison, PG (reprint author), US Army ERDC, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM paul.g.allison@usace.army.mil OI Horstemeyer, Mark/0000-0003-4230-0063 NR 37 TC 3 Z9 3 U1 3 U2 10 PU MANEY PUBLISHING PI LEEDS PA STE 1C, JOSEPHS WELL, HANOVER WALK, LEEDS LS3 1AB, W YORKS, ENGLAND SN 0032-5899 EI 1743-2901 J9 POWDER METALL JI Powder Metall. PD DEC PY 2013 VL 56 IS 5 BP 388 EP 396 DI 10.1179/1743290113Y.0000000063 PG 9 WC Metallurgy & Metallurgical Engineering SC Metallurgy & Metallurgical Engineering GA AI8LK UT WOS:000337166700010 ER PT J AU Mountney, A Shear, DA Potter, B Marcsisin, SR Sousa, J Melendez, V Tortella, FC Lu, XCM AF Mountney, Andrea Shear, Deborah A. Potter, Brittney Marcsisin, Sean R. Sousa, Jason Melendez, Victor Tortella, Frank C. Lu, Xi-Chun M. TI Ethosuximide and Phenytoin Dose-Dependently Attenuate Acute Nonconvulsive Seizures after Traumatic Brain Injury in Rats SO JOURNAL OF NEUROTRAUMA LA English DT Article DE EEG; ETX; NCS; PBBI; PHT; Rats; TBI ID CONVENTIONAL ANTIEPILEPTIC DRUGS; SPONTANEOUSLY EPILEPTIC RAT; MODEL; HEMORRHAGE; ISCHEMIA; LEVETIRACETAM; PROPHYLAXIS; PRESSURE AB Acute seizures frequently occur following severe traumatic brain injury (TBI) and have been associated with poor patient prognosis. Silent or nonconvulsive seizures (NCS) manifest in the absence of motor convulsion, can only be detected via continuous electroencephalographic (EEG) recordings, and are often unidentified and untreated. Identification of effective anti-epileptic drugs (AED) against post-traumatic NCS remains crucial to improve neurological outcome. Here, we assessed the anti-seizure profile of ethosuximide (ETX, 12.5-187.5 mg/kg) and phenytoin (PHT, 5-30 mg/kg) in a spontaneously occurring NCS model associated with penetrating ballistic-like brain injury (PBBI). Rats were divided between two drug cohorts, PHT or ETX, and randomly assigned to one of four doses or vehicle within each cohort. Following PBBI, NCS were detected by continuous EEG monitoring for 72 h post-injury. Drug efficacy was evaluated on NCS parameters of incidence, frequency, episode duration, total duration, and onset latency. Both PHT and ETX attenuated NCS in a dose-dependent manner. In vehicle-treated animals, 69-73% experienced NCS (averaging 9-10 episodes/rat) with average onset of NCS occurring at 30 h post-injury. Compared with control treatment, the two highest PHT and ETX doses significantly reduced NCS incidence to 13-40%, reduced NCS frequency (1.8-6.2 episodes/rat), and delayed seizure onset: <20% of treated animals exhibited NCS within the first 48 h. NCS durations were also dose-dependently mitigated. For the first time, we demonstrate that ETX and PHT are effective against spontaneously occurring NCS following PBBI, and suggest that these AEDs may be effective at treating post-traumatic NCS. C1 [Mountney, Andrea; Shear, Deborah A.; Tortella, Frank C.; Lu, Xi-Chun M.] Walter Reed Army Inst Res, Branch Brain Trauma Neuroprotect & Neurorestorat, Ctr Mil Psychiat & Neurosci, Silver Spring, MD USA. [Potter, Brittney; Marcsisin, Sean R.; Sousa, Jason; Melendez, Victor] Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD USA. RP Mountney, A (reprint author), US Army, Branch Brain Trauma Neuroprotect & Neurorestorat, Ctr Mil Psychiat & Neurosci, Walter Reed Army Inst Res, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM andrea.mountney.mil@mail.mil FU U.S. Army Medical Research and Material Command; Combat Casualty Care Research Program; Defence Medical Research and Development Program [DIO_1_AR_J6_414]; Walter Reed Army Institute of Research FX This work was supported by core funding provided by the U.S. Army Medical Research and Material Command, Combat Casualty Care Research Program and Defence Medical Research and Development Program, Grant DIO_1_AR_J6_414. The work was performed while the first author held a National Research Council Research Associateship Award at Walter Reed Army Institute of Research. NR 39 TC 6 Z9 6 U1 2 U2 9 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 EI 1557-9042 J9 J NEUROTRAUM JI J. Neurotrauma PD DEC PY 2013 VL 30 IS 23 BP 1973 EP 1982 DI 10.1089/neu.2013.3001 PG 10 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA AI0FA UT WOS:000336520400006 PM 23822888 ER PT J AU Vieux, W AF Vieux, Wener TI THE MILITARY RETIREMENT SYSTEM: A PROPOSAL FOR CHANGE SO MILITARY LAW REVIEW LA English DT Article C1 US Army, Washington, DC 20310 USA. RP Vieux, W (reprint author), US Army, Washington, DC 20310 USA. NR 112 TC 0 Z9 0 U1 1 U2 1 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 USA SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD WIN PY 2013 VL 218 BP 1 EP 114 PG 114 WC Law SC Government & Law GA AH7YH UT WOS:000336350800001 ER PT J AU Kersey, AW AF Kersey, Adam W. TI TICKET TO RIDE: STANDARDIZING LICENSURE PORTABILITY FOR MILITARY SPOUSES SO MILITARY LAW REVIEW LA English DT Article ID COURT C1 US Army, Washington, DC 20310 USA. RP Kersey, AW (reprint author), US Army, Washington, DC 20310 USA. NR 60 TC 1 Z9 1 U1 1 U2 1 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 USA SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD WIN PY 2013 VL 218 BP 115 EP 169 PG 55 WC Law SC Government & Law GA AH7YH UT WOS:000336350800002 ER PT J AU Hauptman, A AF Hauptman, Allyson TI AUTONOMOUS WEAPONS AND THE LAW OF ARMED CONFLICT SO MILITARY LAW REVIEW LA English DT Article C1 [Hauptman, Allyson] US Mil Acad, West Point, NY 10996 USA. [Hauptman, Allyson] US Corps Cadets, Manhasset, NY USA. RP Hauptman, A (reprint author), US Mil Acad, West Point, NY 10996 USA. NR 42 TC 1 Z9 1 U1 1 U2 5 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 USA SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD WIN PY 2013 VL 218 BP 170 EP 195 PG 26 WC Law SC Government & Law GA AH7YH UT WOS:000336350800003 ER PT J AU Dalrymple, D AF Dalrymple, Dan TI AN EXTRAORDINARY LIFE SPAN: A SUMMARY AND ANALYSIS OF AN ORAL HISTORY OF THE HONORABLE WILLIAM A. McCLAIN UNITED STATES ARMY (1943-1946) SO MILITARY LAW REVIEW LA English DT Article C1 US Army, Washington, DC 20310 USA. RP Dalrymple, D (reprint author), US Army, Washington, DC 20310 USA. NR 50 TC 0 Z9 0 U1 0 U2 1 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 USA SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD WIN PY 2013 VL 218 BP 196 EP 227 PG 32 WC Law SC Government & Law GA AH7YH UT WOS:000336350800004 ER PT J AU Daskal, J AF Daskal, Josef TI BLEEDING TALENT: HOW THE US MILITARY MISMANAGES GREAT LEADERS AND WHY IT'S TIME FOR A REVOLUTION SO MILITARY LAW REVIEW LA English DT Book Review C1 US Army, Judge Advocate Gen Legal Ctr & Sch, Judge Advocate Officer Grad Course 62, Charlottesville, VA 22911 USA. RP Daskal, J (reprint author), US Army, Judge Advocate Gen Legal Ctr & Sch, Judge Advocate Officer Grad Course 62, Charlottesville, VA 22911 USA. NR 17 TC 0 Z9 0 U1 0 U2 0 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 USA SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD WIN PY 2013 VL 218 BP 281 EP 290 PG 10 WC Law SC Government & Law GA AH7YH UT WOS:000336350800008 ER PT J AU LeMoyne, IC AF LeMoyne, I. C. TI THE GUNS AT LAST LIGHT: THE WAR IN WESTERN EUROPE, 1944-1945 SO MILITARY LAW REVIEW LA English DT Book Review C1 [LeMoyne, I. C.] US Navy, Washington, DC USA. [LeMoyne, I. C.] US Army, Judge Advocate Gen Legal Ctr & Sch, Judge Advocate Officer Grad Course 62, Charlottesville, VA USA. RP LeMoyne, IC (reprint author), US Navy, Washington, DC USA. NR 8 TC 0 Z9 0 U1 0 U2 1 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 USA SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD WIN PY 2013 VL 218 BP 291 EP 299 PG 9 WC Law SC Government & Law GA AH7YH UT WOS:000336350800009 ER PT J AU Croy, T Koppenhaver, S Saliba, S Hertel, J AF Croy, Theodore Koppenhaver, Shane Saliba, Susan Hertel, Jay TI Anterior Talocrural Joint Laxity: Diagnostic Accuracy of the Anterior Drawer Test of the Ankle SO JOURNAL OF ORTHOPAEDIC & SPORTS PHYSICAL THERAPY LA English DT Article DE instability; sensitivity; specificity; ultrasound imaging ID STRESS RADIOGRAPHY; LIGAMENT INJURIES; SPRAIN COPERS; INSTABILITY; RELIABILITY; ULTRASONOGRAPHY; ARTHROGRAPHY; INDIVIDUALS; ULTRASOUND; SONOGRAPHY AB STUDY DESIGN: Prospective, blinded, diagnostic-accuracy study. OBJECTIVES: To investigate the diagnostic accuracy of the ankle anterior drawer test (ADT) to detect anterior talocrural joint laxity in adults with a history of lateral ankle sprain. BACKGROUND: The ADT is used to manually detect anterior talocrural joint laxity following lateral ankle sprain injury; however, the diagnostic accuracy of this test has not been established. METHODS: Sixty-six subjects with a history of lateral ankle sprain were examined with the ADT. Anterior talocrural joint laxity was measured digitally from ultrasound images of the talofibular interval during performance of the ADT. In addition, anterior talocrural joint laxity was measured digitally in 20 control subjects to establish a reference standard. ADT results were defined as "positive" or "negative," based on this and a second reference standard established from the literature. RESULTS: The group with a history of lateral ankle sprain had a mean +/- SD anterior talocrural joint laxity of 3.36 +/- 3.25 mm, compared with 0.17 +/- 1.87 mm in the control group. Thirty-five of 66 (53%) subjects demonstrated anterior talocrural joint laxity at a reference standard of 2.3 mm or greater, and 24(36%) at a reference standard of 3.7 mm or greater. Sensitivity of the ADT was 0.74 (95% confidence interval [CI]: 0.58, 0.86) and 0.83 (95% CI: 0.64, 0.93) at the 2.3 mm or greater and 3.7 mm or greater reference standards, respectively. Specificity of the test was 0.38(95% CI: 0.24, 0.56) and 0.40 (95% CI: 0.27, 0.56), respectively. Positive likelihood ratios were 1.2 and 1.4, whereas the negative likelihood ratios were 0.66 and 0.41, respectively. CONCLUSION: The ADT provides limited ability to detect excessive anterior talocrural joint laxity; however, it may provide useful information when used in side-to-side ankle comparisons and in conjunction with other physical exam procedures, such as palpation. C1 [Croy, Theodore; Koppenhaver, Shane] US Army Baylor Univ Doctoral Program Phys Therapy, US Army Med Specialist Corps, Ft Sam Houston, TX 78234 USA. [Saliba, Susan; Hertel, Jay] Univ Virginia, Kinesiol Program, Charlottesville, VA USA. RP Croy, T (reprint author), US Army Baylor Univ Doctoral Program Phys Therapy, Acad Hlth Sci Attn MCCS HGP, 3599 Winfield Scott Rd,Suite 1215, Ft Sam Houston, TX 78234 USA. EM tcroypt@gmail.com OI Croy, Theodore/0000-0002-3053-8974; Saliba, Susan/0000-0001-7179-8310 FU Retired Army Medical Specialist Corps Association FX The University of Virginia Institutional Review Board for Human Subjects Research approved this study protocol (UVA HSR#14795). Grant funding was provided by the Retired Army Medical Specialist Corps Association. The authors certify that they have no affiliations with or financial involvement in any organization or entity with a direct financial interest in the subject matter or materials discussed in the article. The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the Departments of the Army or Defense. NR 45 TC 7 Z9 7 U1 3 U2 15 PU J O S P T, PI ALEXANDRIA PA 1111 NORTH FAIRFAX ST, STE 100, ALEXANDRIA, VA 22314-1436 USA SN 0190-6011 J9 J ORTHOP SPORT PHYS JI J. Orthop. Sports Phys. Ther. PD DEC PY 2013 VL 43 IS 12 BP 911 EP 919 DI 10.2519/jospt.2013.4679 PG 9 WC Orthopedics; Rehabilitation; Sport Sciences SC Orthopedics; Rehabilitation; Sport Sciences GA AH6KG UT WOS:000336239200007 PM 24175608 ER PT J AU Fansiri, T Fontaine, A Diancourt, L Caro, V Thaisomboonsuk, B Richardson, JH Jarman, RG Ponlawat, A Lambrechts, L AF Fansiri, Thanyalak Fontaine, Albin Diancourt, Laure Caro, Valerie Thaisomboonsuk, Butsaya Richardson, Jason H. Jarman, Richard G. Ponlawat, Alongkot Lambrechts, Louis TI GENETIC BASIS OF VECTOR COMPETENCE FOR FIELD DENGUE VIRUS ISOLATES IN A WILD AEDES AEGYPTI POPULATION SO PATHOGENS AND GLOBAL HEALTH LA English DT Meeting Abstract C1 [Fansiri, Thanyalak; Fontaine, Albin; Lambrechts, Louis] Inst Pasteur, CNRS, Unite Rech Associe 3012, Paris, France. [Fansiri, Thanyalak; Richardson, Jason H.; Ponlawat, Alongkot] Armed Forces Res Inst Med Sci, Dept Entomol, Bangkok 10400, Thailand. [Diancourt, Laure; Caro, Valerie] Inst Pasteur, Genotyping Pathogens & Publ Hlth Unit, Paris, France. [Thaisomboonsuk, Butsaya; Jarman, Richard G.] Armed Forces Res Inst Med Sci, Dept Virol, Bangkok 10400, Thailand. NR 0 TC 1 Z9 1 U1 1 U2 5 PU MANEY PUBLISHING PI LEEDS PA STE 1C, JOSEPHS WELL, HANOVER WALK, LEEDS LS3 1AB, W YORKS, ENGLAND SN 2047-7724 EI 2047-7732 J9 PATHOG GLOB HEALTH JI Pathog. Glob. Health PD DEC PY 2013 VL 107 IS 8 BP 402 EP 402 PG 1 WC Public, Environmental & Occupational Health; Parasitology; Tropical Medicine SC Public, Environmental & Occupational Health; Parasitology; Tropical Medicine GA AF9SZ UT WOS:000335056200011 ER PT J AU Kelley, AM Cheung, B Lawson, BD Rath, E Chiasson, J Ramiccio, JG Rltpert, AH AF Kelley, Amanda M. Cheung, Bob Lawson, Benton D. Rath, Edna Chiasson, John Ramiccio, John G. Rltpert, Angus H. TI Tactile Cues for Orienting Pilots During Hover Over Moving Targets SO AVIATION SPACE AND ENVIRONMENTAL MEDICINE LA English DT Article DE tactile cues; hover maneuver; fatigue; degraded visual; environment AB Introduction: Providing information via the tactile sensory system allows the pilot to increase awareness without further taxing the visual and auditory perceptual systems. In this study, tactile cues were presented to pilots for target orientation during a simulated helicopter extraction over a moving target. The efficacy of the cues provided by the tactile system was assessed under various conditions (rested vs. fatigued, clear vs. degraded visual environment). Methods: This study employed a mixedmodel 24 factorial design, including one between-subjects variable (training amount: minimal, additional) and three within-subjects variables (state: rested, fatigued; visual environment: clear, degraded; tactile cue belt: active, inactive). Across 2 d under the 4 test conditions, 16 UH-60 rated, healthy aviators completed 8 sessions of 10-min stabilized hovering maneuvers over a moving target. All flights were conducted in a UH-60 flight simulator. Results: Subjects were able to stay closer to the target when the tactile cuing system was active (M = 31.14 ft, SE = 3.17 ft) vs. inactive (M = 36.33 ft, SE = 2.84 ft). Likewise, subjects rated their situation awareness as greater when the tactile system was active vs. inactive. Discussion: The results support the efficacy of the tactile system in providing directional cues for maintaining pilot performance during a hover maneuver over a moving target. C1 [Kelley, Amanda M.; Lawson, Benton D.; Rath, Edna; Ramiccio, John G.; Rltpert, Angus H.] US Army, Aeromed Res Lab, Ft Rucker, AL USA. [Cheung, Bob] Def Res & Dev Canada, Toronto, ON, Canada. [Chiasson, John] Henry M Jackson Fdn, Bethesda, MD USA. RP Kelley, AM (reprint author), Natl Highway Traff Safety Adm US, Off Behav Safety Res, W Bldg 46-495,1200 New Jersey Ave SE,NTI-132, Washington, DC 20590 USA. EM amanda.kelley@dot.gov FU Defence Research and Development Canada; Department of National Defence FX The authors would like to acknowledge the dedication and professionalism of the research pilots of the Flight Systems Branch and the research staff of the Warfighter Health Division, U.S. Army Aeromedical Research Laboratory for their contributions to the success of this project. This study was partially funded by Defence Research and Development Canada, Department of National Defence. A detailed technical report of this study is available by contacting the USAARL Science Information Center at 334-255-6907. USAARL technical reports included in the reference list are available from the Defense Technical Information Center or USAARL Science Information Center. NR 13 TC 4 Z9 4 U1 0 U2 0 PU AEROSPACE MEDICAL ASSOC PI ALEXANDRIA PA 320 S HENRY ST, ALEXANDRIA, VA 22314-3579 USA SN 0095-6562 EI 1943-4448 J9 AVIAT SPACE ENVIR MD JI Aviat. Space Environ. Med. PD DEC PY 2013 VL 84 IS 12 BP 1255 EP 1261 DI 10.3357/ASEM.3669.2013 PG 7 WC Public, Environmental & Occupational Health; Medicine, General & Internal; Sport Sciences SC Public, Environmental & Occupational Health; General & Internal Medicine; Sport Sciences GA AD1LZ UT WOS:000332996800005 PM 24459796 ER PT J AU Han, JS Edney, MT Gonzalez, CM AF Han, Justin S. Edney, Mark T. Gonzalez, Chris M. TI Genitourinary Trauma in the Modern Era of Warfare SO JOURNAL OF MENS HEALTH LA English DT Review DE fertility; genitourinary; military; sexual dysfunction; trauma ID OPERATION IRAQI FREEDOM; TESTICULAR CANCER SURVIVORS; QUALITY-OF-LIFE; EXTERNAL GENITALIA; SEXUAL FUNCTION; LONG-TERM; INJURIES; MEN; WAR AB Genitourinary trauma has become increasingly commonplace in the modern era of warfare. During the global war on terror, rates of genitourinary injuries have increased by nearly 350%. The rise in genitourinary battlefield injuries can be largely attributed to changing mechanisms of modern combat and the proliferation of improvised explosive devices (IEDs). In the current ongoing conflicts, IED use has replaced traditional artillery as the leading source of combat-related injuries. Developments in body armor and other protective mechanisms have also led to a shift in genitourinary organ system involvement, with external genitalia and pelvic wounds exceeding intra-abdominal injuries. Furthermore, soldiers are more often surviving their battlefield injuries and facing chronic debilitating injuries infrequently encountered in past wars. The impact of these battlefield wounds is largely unstudied and unknown. Many of the genitourinary injuries have devastating potential long-term consequences on quality of life. To date, no study has been published specifically examining the psychological, sexual, hormonal, and fertility effects of genitourinary injuries. Legislative efforts are underway to address deficiencies in funding, research, prevention, and treatment of genitourinary wartime trauma. C1 [Han, Justin S.; Gonzalez, Chris M.] Northwestern Univ, Feinberg Sch Med, Dept Urol, Chicago, IL 60611 USA. [Han, Justin S.; Gonzalez, Chris M.] Jesse Brown Vet Affairs Med Ctr, Chicago, IL USA. [Edney, Mark T.] Peninsula Urol Associates, Salisbury, MD USA. [Edney, Mark T.] US Army Reserve, Med Corps, Combat Support Hosp 48, Ft George G Meade, MD USA. RP Gonzalez, CM (reprint author), Northwestern Univ, Feinberg Sch Med, Dept Urol, 303 E Chicago Ave,Tarry 16-703, Chicago, IL 60611 USA. EM cgonzalez@nmff.org NR 23 TC 3 Z9 3 U1 1 U2 4 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1875-6867 EI 1875-6859 J9 J MENS HEALTH JI J. Mens Health PD DEC PY 2013 VL 10 IS 4 BP 124 EP 128 DI 10.1089/jomh.2013.1504 PG 5 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AD2AA UT WOS:000333033600003 ER PT J AU Bahrampour, S Ray, A Sarkar, S Damarla, T Nasrabadi, NM AF Bahrampour, Soheil Ray, Asok Sarkar, Soumalya Damarla, Thyagaraju Nasrabadi, Nasser M. TI Performance comparison of feature extraction algorithms for target detection and classification SO PATTERN RECOGNITION LETTERS LA English DT Article DE Feature extraction; Pattern classification; Unattended ground sensors: border control ID TRACKING; SYSTEMS AB This paper addresses the problem of target detection and classification, where the performance is often limited due to high rates of false alarm and classification error, possibly because of inadequacies in the underlying algorithms of feature extraction from sensory data and subsequent pattern classification. In this paper, a recently reported feature extraction algorithm, symbolic dynamic filtering (SDF), is investigated for target detection and classification by using unmanned ground sensors (UGS). In SDF, sensor time series data are first symbolized to construct probabilistic finite state automata (PFSA) that, in turn, generate low-dimensional feature vectors. In this paper, the performance of SDF is compared with that of two commonly used feature extractors, namely Cepstrum and principal component analysis (PCA), for target detection and classification. Three different pattern classifiers have been employed to compare the performance of the three feature extractors for target detection and human/animal classification by UGS systems based on two sets of field data that consist of passive infrared (PIR) and seismic sensors. The results show consistently superior performance of SDF-based feature extraction over Cepstrum-based and PCA-based feature extraction in terms of successful detection, false alarm, and misclassification rates. (C) 2013 Elsevier B. V. All rights reserved. C1 [Bahrampour, Soheil] Penn State Univ, Dept Elect Engn, University Pk, PA 16802 USA. [Ray, Asok; Sarkar, Soumalya] Penn State Univ, Dept Mech Engn, University Pk, PA 16802 USA. [Damarla, Thyagaraju; Nasrabadi, Nasser M.] Army Res Lab, Adelphi, MD 20783 USA. RP Ray, A (reprint author), Penn State Univ, Dept Mech Engn, University Pk, PA 16802 USA. EM soheil@psu.edu; axr2@psu.edu; svs5464@psu.edu; thyagaraju.damarla.civ@mail.mil; nasser.m.nasrabadi.civ@mail.mil FU U.S. Army Research Laboratory; U.S. Army Research Office [W911NF-07-1-0376]; U.S. Air Force Office of Scientific Research (AFOSR) [FA9550-12-1-0270] FX This work has been supported in part by the U.S. Army Research Laboratory and the U.S. Army Research Office under Grant No. W911NF-07-1-0376, and by the U.S. Air Force Office of Scientific Research (AFOSR) under Grant No. FA9550-12-1-0270. Any opinions, findings and conclusions or recommendations expressed in this publication are those of the authors and do not necessarily reflect the views of the sponsoring agencies. NR 22 TC 15 Z9 17 U1 0 U2 13 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0167-8655 EI 1872-7344 J9 PATTERN RECOGN LETT JI Pattern Recognit. Lett. PD DEC 1 PY 2013 VL 34 IS 16 BP 2126 EP 2134 DI 10.1016/j.patrec.2013.06.021 PG 9 WC Computer Science, Artificial Intelligence SC Computer Science GA AD2YY UT WOS:000333104500011 ER PT J AU Lee, BB Andrade, M Antignani, PL Boccardo, F Bunke, N Campisi, C Damstra, R Flour, M Forner-Cordero, I Gloviczki, P Laredo, J Partsch, H Piller, N Michelini, S Mortimer, P Rabe, E Rockson, S Scuderi, A Szolnoky, G Villavicencio, JL AF Lee, B. B. Andrade, M. Antignani, P. L. Boccardo, F. Bunke, N. Campisi, C. Damstra, R. Flour, M. Forner-Cordero, I. Gloviczki, P. Laredo, J. Partsch, H. Piller, N. Michelini, S. Mortimer, P. Rabe, E. Rockson, S. Scuderi, A. Szolnoky, G. Villavicencio, J. L. TI Diagnosis and Treatment of Primary Lymphedema Consensus Document of the International Union of Phlebology (IUP)-2013 SO INTERNATIONAL ANGIOLOGY LA English DT Article DE Primary lymphedema; Truncular lymphatic malformation; Decongestive Lymphatic Therapy; Reconstructive surgery; Ablative surgery; Compression therapy; Compliance; Gene-oriented management ID CONGENITAL VASCULAR MALFORMATIONS; ELEPHANTIASIS-NOSTRAS-VERRUCOSA; KLIPPEL-TRENAUNAY-SYNDROME; CANCER-RELATED LYMPHEDEMA; CHRONIC VENOUS INSUFFICIENCY; REDUCES ARM LYMPHEDEMA; OF-THE-LITERATURE; BREAST-CANCER; HEREDITARY LYMPHEDEMA; COMPRESSION THERAPY AB Primary lymphedema can be managed effectively as a form of chronic lymphedema by a sequenced and targeted treatment and management program based around a combination of Decongestive Lymphatic Therapy (DLT) with compression therapy, when the latter is desired as an adjunct to DLT. Treatment in the maintenance phase should include compression garments, self-management, including self-massage, meticulous personal hygiene and skin care, in addition to lymphtransport-promoting excercises and activities, and, if desired, pneumatic compression therapy applied in the home. When conservative treatment fails, or gives sub-optimal outcomes, the management of primary lymphedema can be improved, where appropriate, with the proper addition of surgical interventions, either reconstructive or ablative. These two surgical therapies can be more effective when fully integrated with manual lymphatic drainage (MLD)-based DLT postoperatively. Compliance with a long-term commitment to MLD/DLT and particularly compression postoperatively is a critical factor in determining the success of any new treatment strategy involving either reconstructive or palliative surgery. The future of management of primary lymphedema has never been brighter with the new prospect of gene-and perhaps stem-cell oriented management. C1 [Lee, B. B.] George Washington Univ, Div Vasc Surg, Dept Surg, Ctr Vein Lymphat & Vasc Malformat,Sch Med, Washington, DC 20037 USA. [Andrade, M.] Univ Sao Paulo, Sch Med, Dept Surg, Sao Paulo, Brazil. [Antignani, P. L.] Villa Claudia, Vasc Ctr, Rome, Italy. [Boccardo, F.] Univ Genoa, Unit Lymphat Surg, Dpt Surg, Sect Lymphol & Microsurg,Univ Hosp S Martino, Genoa, Italy. Univ Calif San Diego, Sect Endovasc & Vasc Surg, San Diego, CA 92103 USA. [Campisi, C.] Univ Hosp S Martino, Sect Lyrnphol & Microsurg, Operat Unit Lymphat Surg, Dpt Surg, Genoa, Italy. [Damstra, R.] Nij Smellinghe Hosp, Dept Dermatol Phlebol & Lymphovasc Med, Drachten, Netherlands. [Flour, M.] Univ Hosp Leuven, Multidisciplinary Diabet Foot Clin, Vasc Ctr, Dept Dermatol, Louvain, Belgium. [Forner-Cordero, I.] Hosp Univ La Fe, Rehabil Dept, Lymphedema Unit, Valencia, Spain. [Gloviczki, P.] Mayo Clin, Coll Med, Rochester, MN USA. [Gloviczki, P.] Mayo Clin, Gonda Vasc Ctr, Div Vasc & Endovasc Surg, Rochester, MN USA. [Laredo, J.] George Washington Univ, Div Vasc Surg, Dept Surg, Ctr Lymphedema & Vasc Malformat,Sch Med, Washington, DC 20037 USA. [Michelini, S.] San Giovanni Battista Hosp, European Soc Lymphol, Rome, Italy. [Michelini, S.] San Giovanni Battista Hosp, Dept Vasc Rehabil, Rome, Italy. [Mortimer, P.] Univ London, Clin Sci Div Dermatol, London, England. [Partsch, H.] Wilhelminen Hosp, Dept Dermatol, Vienna, Austria. [Scuderi, A.] Santa Lucinda Hosp, Sorocaba, Brazil. [Scuderi, A.] Pontificial Catholic Univ Sao Paulo, Sao Paulo, Brazil. [Scuderi, A.] UIP, Sao Paulo, Brazil. [Szolnoky, G.] Univ Szeged, Dept Dermatol & Allergol, Szeged, Hungary. [Piller, N.] Flinders Univ S Australia, MD Program, Adelaide, SA 5001, Australia. [Piller, N.] Flinders Univ S Australia, Sch Med, Dept Surg, Lymphoedema Res Unit, Adelaide, SA 5001, Australia. [Piller, N.] Flinders Med Ctr, Adelaide, SA, Australia. [Rabe, E.] Univ Bonn, Dept Dermatol, D-53105 Bonn, Germany. [Rockson, S.] Stanford Univ, Sch Med, Stanford, CA 94305 USA. [Rockson, S.] Stanford Univ, Sch Med, Stanford Ctr Lymphat & Venous Disorders, Stanford, CA 94305 USA. [Villavicencio, J. L.] Uniformed Serv Univ Hlth Sci, Sch Med, Dept Surg, Bethesda, MD 20814 USA. [Villavicencio, J. L.] Walter Reed Army Med Ctr, Venous & Lymphat Teaching Clin, Bethesda, MD USA. RP Lee, BB (reprint author), George Washington Univ, Div Vasc Surg, Dept Surg, Med Ctr, 22nd & 1 St,NW,6th Floor, Washington, DC 20037 USA. NR 291 TC 12 Z9 12 U1 0 U2 20 PU EDIZIONI MINERVA MEDICA PI TURIN PA CORSO BRAMANTE 83-85 INT JOURNALS DEPT., 10126 TURIN, ITALY SN 0392-9590 EI 1827-1839 J9 INT ANGIOL JI Int. Angiol. PD DEC PY 2013 VL 32 IS 6 BP 541 EP 574 PG 34 WC Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA AA8KN UT WOS:000331344500001 PM 24212289 ER PT J AU Shaffer, SW Koreerat, NR Gordon, LB Santillo, DR Moore, JH Greathouse, DG AF Shaffer, Scott W. Koreerat, Nicholas R. Gordon, Lindsay B. Santillo, Douglas R. Moore, Josef H. Greathouse, David G. TI Median and Ulnar Neuropathies in US Army Medical Command Band Members SO MEDICAL PROBLEMS OF PERFORMING ARTISTS LA English DT Article; Proceedings Paper CT Combined Sections Meeting of the American-Physical-Therapy-Association CY FEB 09-12, 2011 CL New Orleans, LA SP Amer Phys Therapy Assoc ID CARPAL-TUNNEL-SYNDROME; INSTRUMENTAL MUSICIANS; MUSCULOSKELETAL DISORDERS; PRACTICE PARAMETER; NERVE-CONDUCTION; OVERUSE SYNDROME; RISK-FACTORS; POPULATION; PREVALENCE; HAND AB PURPOSE: Musicians have been reported as having a high prevalence of upper-extremity musculoskeletal disorders, including carpal tunnel syndrome. The purpose of this study was to determine the presence of median and ulnar neuropathies in U.S. Army Medical Command (MEDCOM) Band members at Fort Sam Houston, Texas. METHODS: Thirty-five MEDCOM Band members (30 males, 5 females) volunteered to participate. There were 33 right-handed musicians, and the mean length of time in the MEDCOM Band was 12.2 yrs (range, 1-30 yrs). Subjects completed a history form, were interviewed, and underwent a physical examination of the cervical spine and bilateral upper extremities. Nerve conduction studies of the bilateral median and ulnar nerves were performed. Electrophysiological variables served as the reference standard for median and ulnar neuropathy and included distal sensory latencies, distal motor latencies, amplitudes, conduction velocities, and comparison study latencies. RESULTS: Ten of the 35 subjects (29%) presented with abnormal electrophysiologic values suggestive of an upper extremity mononeuropathy. Nine of the subjects had abnormal median nerve electrophysiologic values at or distal to the wrist; 2 had bilateral abnormal values. One had an abnormal ulnar nerve electrophysiologic assessment at the elbow. Nine of these 10 subjects had clinical examination findings consistent with the electrophysiological findings. CONCLUSIONS: The prevalence of mononeuropathies in this sample of band members is similar to that found in previous research involving civilian musicians (20-36%) and far exceeds that reported in the general population. Prospective research investigating screening, examination items, and injury prevention measures in musicians appears to be warranted. C1 [Shaffer, Scott W.; Moore, Josef H.] US Army, Adelphi, MD USA. [Shaffer, Scott W.; Koreerat, Nicholas R.; Greathouse, David G.] US Army Baylor Univ Doctoral Program Phys Therapy, Ft Sam Houston, TX USA. [Shaffer, Scott W.] Army Med Specialist Corps, Off Surgeon Gen, Phys Therapist Sect, Falls Church, VA USA. [Shaffer, Scott W.] Army Med Specialist Corps, Off Surgeon Gen, Falls Church, VA USA. [Koreerat, Nicholas R.; Gordon, Lindsay B.; Santillo, Douglas R.] US Army Doctoral Program Phys Therapy, Ft Sam Houston, TX USA. [Greathouse, David G.] Texas Phys Therapy Specialists, Clin Electrophysiol Serv, New Braunfels, TX 78130 USA. RP Greathouse, DG (reprint author), Texas Phys Therapy Specialists, Clin Electrophysiol Serv, 1324 Common St,Suite 307, New Braunfels, TX 78130 USA. EM greathoused1@yahoo.com NR 59 TC 2 Z9 2 U1 2 U2 3 PU SCIENCE & MEDICINE INC PI NARBERTH PA PO BOX 313, NARBERTH, PA 19072 USA SN 0885-1158 J9 MED PROBL PERFORM AR JI Med. Probl. Perform. Artist. PD DEC PY 2013 VL 28 IS 4 BP 188 EP 194 PG 7 WC Medicine, General & Internal; Music SC General & Internal Medicine; Music GA AB0KI UT WOS:000331480300003 PM 24337029 ER PT J AU Kaber, DB Naylor, JT Gil, GH Pankok, C Kim, SH AF Kaber, David B. Naylor, James T. Gil, Guk-Ho Pankok, Carl Kim, Sang-Hwan TI Influence of Flight Domain and Cockpit Display Dynamics on Pilot Perceived Clutter SO JOURNAL OF AEROSPACE INFORMATION SYSTEMS LA English DT Article ID TARGET DETECTION; PERFORMANCE AB Two analyses were conducted on three datasets from a series of aviation human factors experiments focused on the development and testing of measures of flight display clutter as well as the relation with flight task performance. The objectives of this study were to assess the effects of cockpit display dynamics and aircraft type on pilot perceptions of display clutter in simulated flight tasks through statistical analyses of the data gathered across the experimental studies. Comparisons were made on observations of pilots with comparable experience under similar headup or headdown display conditions. In general, this research demonstrated the clutter measures to be highly sensitive to aviation display and domain conditions. The findings also indicated that human information processing considerations in aviation display design coupled with attention to the visual characteristics of display features may provide an effective basis for mitigating potential effects of clutter on pilot performance. C1 [Kaber, David B.; Gil, Guk-Ho; Pankok, Carl] N Carolina State Univ, Dept Ind & Syst Engn, Raleigh, NC 27695 USA. [Naylor, James T.] US Army Special Operat Command, Dept Technol Applicat Program Off, Ft Eustis, VA 23604 USA. [Kim, Sang-Hwan] Univ Michigan, Dept Ind & Syst Engn, Dearborn, MI 48128 USA. RP Kaber, DB (reprint author), N Carolina State Univ, Dept Ind & Syst Engn, Campus Box 7906, Raleigh, NC 27695 USA. FU NASA [NNL06AA21A, NNX09AN72A] FX This research was a thesis work based on previous research that was supported by NASA grants NNL06AA21A and NNX09AN72A. The technical monitors were Lance Prinzel and Randy Bailey. The opinions expressed are those of the authors and do not necessarily reflect the views of NASA. NR 17 TC 1 Z9 1 U1 0 U2 1 PU AMER INST AERONAUTICS ASTRONAUTICS PI RESTON PA 1801 ALEXANDER BELL DRIVE, STE 500, RESTON, VA 22091-4344 USA SN 1940-3151 EI 2327-3097 J9 J AEROSP INFORM SYST JI J. Aerosp. Inf. Syst. PD DEC PY 2013 VL 10 IS 12 BP 550 EP 559 DI 10.2514/1.I010036 PG 10 WC Engineering, Aerospace SC Engineering GA AB2GU UT WOS:000331612000002 ER PT J AU Corona, JC Jenkins, DM Holland, TJB AF Corona, Juan Carlos Jenkins, David M. Holland, Timothy J. B. TI CONSTRAINTS ON THE UPPER PRESSURE STABILITY OF BLUESCHIST FACIES METAMORPHISM ALONG THE REACTION: GLAUCOPHANE = TALC+2 JADEITE IN THE Na2O-MgO-Al2O3-SiO2-H2O SYSTEM SO AMERICAN JOURNAL OF SCIENCE LA English DT Article DE glaucophane; nyboite; talc; aspidolite; THERMOCALC; P-T stability; UHP metamorphism ID ZERMATT-SAAS OPHIOLITE; X-RAY; CRYSTAL-STRUCTURE; PETROLOGICAL CALCULATIONS; TEMPERATURE-DEPENDENCE; SYNCHROTRON-RADIATION; THERMODYNAMIC MODEL; CENTRAL CHINA; WESTERN ALPS; QUARTZ AB Blueschist-facies metamorphism, which is associated with high pressure and low temperature subduction zone metamorphism, is usually recognized by the presence of the sodic-amphibole glaucophane. Determining the upper- and lower-pressure stability of end-member glaucophane places important constraints on the conditions of blueschist metamorphism. An experimental investigation into the upper-pressure stability, of glaucophane has been done in the system Na2O-MgO-Al2O3-SiO2-H2O over the range of 600 to 750 degrees C and 2.5 to 4.5 GPa. Mixtures of synthetic glaucophane, jadeite, and talc were used to determine the location of the reaction boundary glaucophane = 2 jadeite + talc by reversing the sense of reaction direction. The upper-pressure stability of glaucophane is located over a pressure interval (0.2-0.3 GPa in width) whose midpoints lie at 2.6 GPa at 600 degrees C and at 3.1 GPa at 700 degrees C, across which the proportion of glaucophane decreases to zero as talc and jadeite increase. This band has a positive dP/dT slope of around 0.005 GPa/degrees C. Glaucophane showed the largest change in composition, consistent with the incorporation of significant amounts of the nyboite (17-34 mol%) and cummingtonite (10-18 mol%) components. Talc showed minor, but definite incorporation of Na (0.08 atoms per formula unit, apfu) and Al (0.15 apfu) consistent with incorporation of the components aspidolite and tschermak-talc. Jadeite displayed no clear change from its ideal composition. The results from this study were combined with the lower-pressure stability of glaucophane + quartz reported earlier by Corona and Jenkins (2007) to refine the thermodynamic values for glaucophane (Delta H-f degrees = -11,956.36 kJ/mol), report an initial set of values for the amphibole nyboite (Delta H-f degrees = -12,165.85 kJ/mol) and phyllosilicate aspidolite (Delta H-f degrees = -6163.86 kJ/mol), and to develop activity-composition relationships for both the amphibole and talc in this chemical system. The results of this study place an upper-pressure limit to a key index mineral of the blueschist-facies at about 3.2 GPa at 700 degrees C, which is just above the quartz-coesite transition, allowing nearly end-member glaucophane to remain stable up to the conditions of ultra-high-pressure metamorphism. C1 [Corona, Juan Carlos; Jenkins, David M.] SUNY Binghamton, Dept Geol Sci & Environm Studies, Binghamton, NY 13902 USA. [Holland, Timothy J. B.] Univ Cambridge, Dept Earth Sci, Cambridge CB2 3EQ, England. RP Corona, JC (reprint author), US Army Corps Engineers, 100 Penn Sq East,Wanamaker Bldg, Philadelphia, PA 19107 USA. EM juan.c.corona@usace.army.mil NR 57 TC 2 Z9 2 U1 0 U2 8 PU AMER JOURNAL SCIENCE PI NEW HAVEN PA YALE UNIV, PO BOX 208109, NEW HAVEN, CT 06520-8109 USA SN 0002-9599 EI 1945-452X J9 AM J SCI JI Am. J. Sci. PD DEC PY 2013 VL 313 IS 10 BP 967 EP 995 DI 10.2475/10.2013.01 PG 29 WC Geosciences, Multidisciplinary SC Geology GA 299TN UT WOS:000330418700001 ER PT J AU Corbett, JF AF Corbett, John F. TI China's Security State: Philosophy, Evolution, and Politics SO CHINA QUARTERLY LA English DT Book Review C1 [Corbett, John F.] CENTRA Technol Inc, Burlington, MA 01803 USA. [Corbett, John F.] US Army, Adelphi, MD USA. [Corbett, John F.] China Foreign Area Officer FAO, Washington, DC USA. [Corbett, John F.] Army Attache, Beijing, Peoples R China. RP Corbett, JF (reprint author), CENTRA Technol Inc, Burlington, MA 01803 USA. EM johnfcorbett@atmc.net NR 1 TC 0 Z9 0 U1 0 U2 2 PU CAMBRIDGE UNIV PRESS PI NEW YORK PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA SN 0305-7410 EI 1468-2648 J9 CHINA QUART JI China Q. PD DEC PY 2013 IS 216 BP 1069 EP 1071 DI 10.1017/S0305741013001203 PG 5 WC Area Studies SC Area Studies GA 298XI UT WOS:000330357400016 ER PT J AU Bailey, JA Morrison, JJ Rasmussen, TE AF Bailey, Jeffrey A. Morrison, Jonathan J. Rasmussen, Todd E. TI Military trauma system in Afghanistan: lessons for civil systems? SO CURRENT OPINION IN CRITICAL CARE LA English DT Review DE en route care; performance improvement; tactical evacuation; trauma system ID EN-ROUTE CARE; BATTLEFIELD; MORTALITY; DEATH AB Purpose of review This review focuses on development and maturation of the tactical evacuation and en route care capabilities of the military trauma system in Afghanistan and discusses hard-learned lessons that may have enduring relevance to civilian trauma systems. Recent findings Implementation of an evidence-based, data-driven performance improvement programme in the tactical evacuation and en route care elements of the military trauma system in Afghanistan has delivered measured improvements in casualty care outcomes. Summary Transfer of the lessons learned in the military trauma system operating in Afghanistan to civilian trauma systems with a comparable burden of prolonged evacuation times may be realized in improved patient outcomes in these systems. C1 [Bailey, Jeffrey A.; Rasmussen, Todd E.] US Army Inst Surg Res, Ft Sam Houston, TX USA. [Bailey, Jeffrey A.; Rasmussen, Todd E.] Uniformed Serv Univ Hlth Sci, Norman M Rich Dept Surg, Bethesda, MD 20814 USA. [Morrison, Jonathan J.] Royal Ctr Def Med, Acad Dept Mil Surg & Trauma, Birmingham, W Midlands, England. [Morrison, Jonathan J.] Glasgow Royal Infirm, Acad Surg Unit, Glasgow G4 0SF, Lanark, Scotland. RP Bailey, JA (reprint author), US Army Inst Surg Res, 3698 Chambers Pass Bldg 3611, Jbsa Ft Sam Houston, TX 78234 USA. EM jeffrey.a.bailey3.mil@mail.mil OI Morrison, Jonathan/0000-0001-7462-8456 NR 19 TC 11 Z9 12 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1070-5295 EI 1531-7072 J9 CURR OPIN CRIT CARE JI Curr. Opin. Crit. Care PD DEC PY 2013 VL 19 IS 6 BP 569 EP 577 DI 10.1097/MCC.0000000000000037 PG 9 WC Critical Care Medicine SC General & Internal Medicine GA 298XN UT WOS:000330358100008 PM 24240822 ER PT J AU Moulton, SL Mulligan, J Grudic, GZ Convertino, VA AF Moulton, Steven L. Mulligan, Jane Grudic, Greg Z. Convertino, Victor A. TI Running on empty? The compensatory reserve index SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY LA English DT Article DE Hypotension; lower-body negative pressure; pulse oximetry ID BODY NEGATIVE-PRESSURE; CENTRAL HYPOVOLEMIA; HEART-RATE; EARLY INDICATOR; VITAL SIGN; HUMANS; RESPONSES; TRAUMA; VARIABILITY; ASSOCIATION AB BACKGROUND: Hemorrhage is a leading cause of traumatic death. We hypothesized that state-of-the-art feature extraction and machine learning techniques could be used to discover, detect, and continuously trend beat-to-beat changes in arterial pulse waveforms associated with the progression to hemodynamic decompensation. METHODS: We exposed 184 healthy humans to progressive central hypovolemia using lower-body negative pressure to the point of hemodynamic decompensation (systolic blood pressure > 80 mm Hg with or without bradycardia). Initial models were developed using continuous noninvasive blood pressure waveform data. The resulting algorithm calculates a compensatory reserve index (CRI), where 1 represents supine normovolemia and 0 represents the circulatory volume at which hemodynamic decompensation occurs (i.e., "running on empty"). Values between 1 and 0 indicate the proportion of reserve remaining before hemodynamic decompensation-much like the fuel gauge of a car indicates the amount of fuel remaining in the tank. A CRI estimate is produced after the first 30 heart beats, followed by a new CRI estimate after each subsequent beat. RESULTS: The CRI model with a 30-beat window has an absolute difference between actual and expected time to decompensation of 0.1, with a SD of 0.09. The model distinguishes individuals with low tolerance to reduced central blood volume (i.e., those most likely to develop early shock) from those with high tolerance and are able to estimate how near or far an individual may be from hemodynamic decompensation. CONCLUSION: Machine modeling can quickly and accurately detect and trend central blood volume reduction in real time during the compensatory phase of hemorrhage as well as estimate when an individual is "running on empty" and will decompensate (CRI, 0), well in advance of meaningful changes in traditional vital signs. Copyright (C) 2013 by Lippincott Williams & Wilkins C1 [Moulton, Steven L.] Univ Colorado, Sch Med, Dept Surg, Aurora, CO USA. [Moulton, Steven L.; Mulligan, Jane; Grudic, Greg Z.] Flashback Technol Inc, Boulder, CO USA. [Convertino, Victor A.] US Army Inst Surg Res, JBSA Ft Sam Houston, San Antonio, TX USA. RP Moulton, SL (reprint author), Childrens Hosp Colorado, B-323,13123 E 16th Ave, Aurora, CO 80045 USA. EM steven.moulton@childrenscolorado.org FU US Army Medical Research and Materiel Command Combat Casualty Research Program; US Army Small Business Innovative Research (SBIR) program; US Army Medical Research and Material Command (USAMRMC) [W81XWH-09-1-0750, W81XWH-09-C-0160, W81XWH-11-2-0091, W81XWH-11-2-0085, W81XWH-12-2-0112] FX This research was supported in part by funding from the US Army Medical Research and Materiel Command Combat Casualty Research Program and the US Army Small Business Innovative Research (SBIR) program. G.Z.G. and J.M. codeveloped the CRI model used in this study. S. L. M. is a cofounder and medical consultant to Flashback Technologies, Inc. V. A. C. has disclosed no conflicts of interest.; This work is supported in part by funding from the US Army Medical Research and Material Command (USAMRMC) under Grant Nos. W81XWH-09-1-0750, W81XWH-09-C-0160, W81XWH-11-2-0091, W81XWH-11-2-0085, and W81XWH-12-2-0112. NR 40 TC 23 Z9 24 U1 0 U2 5 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 2163-0755 EI 2163-0763 J9 J TRAUMA ACUTE CARE JI J. Trauma Acute Care Surg. PD DEC PY 2013 VL 75 IS 6 BP 1053 EP 1059 DI 10.1097/TA.0b013e3182aa811a PG 7 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 300IR UT WOS:000330458100028 PM 24256681 ER PT J AU Martell, D Ramsey, M Burton, B Honda, S Newman, S AF Martell, David Ramsey, Mitchell Burton, Bradford Honda, Stacey Newman, Scott TI Intravascular Extension of a Glomus Jugulare SO OTOLOGY & NEUROTOLOGY LA English DT Editorial Material C1 [Martell, David; Ramsey, Mitchell] Tripler Army Med Ctr, Dept Otolaryngol, Tripler, HI 96859 USA. [Burton, Bradford] Kaiser Permanent, Dept Radiol, Honolulu, HI USA. [Honda, Stacey] Kaiser Permanent, Dept Pathol, Honolulu, HI USA. [Newman, Scott] Dept Otolaryngol, Maui, HI USA. RP Martell, D (reprint author), Tripler Army Med Ctr, Dept Otolaryngol, 1 Jarrett White Rd, Tripler, HI 96859 USA. EM David.Martell2@us.army.mil NR 5 TC 0 Z9 0 U1 1 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1531-7129 EI 1537-4505 J9 OTOL NEUROTOL JI Otol. Neurotol. PD DEC PY 2013 VL 34 IS 9 BP E125 EP E127 PG 3 WC Clinical Neurology; Otorhinolaryngology SC Neurosciences & Neurology; Otorhinolaryngology GA 301HY UT WOS:000330524600002 PM 24080975 ER PT J AU Bookstaver, PB Bland, CM Qureshi, ZP Faulkner-Fennell, CM Sheldon, MA Caulder, CR Hartis, C AF Bookstaver, P. Brandon Bland, Christopher M. Qureshi, Zaina P. Faulkner-Fennell, Carmen M. Sheldon, Margrit A. Caulder, Celeste R. Hartis, Charles CA SERGE-45 Investigators TI Safety and Effectiveness of Daptomycin Across a Hospitalized Obese Population: Results of a Multicenter Investigation in the Southeastern United States SO PHARMACOTHERAPY LA English DT Article DE obesity; daptomycin; Staphylococcus aureus; morbid obesity; creatine phosphokinase; HMG Co-A reductase ID CLASSIFICATION TREE ANALYSIS; SURGICAL SITE INFECTIONS; HIGH-DOSE DAPTOMYCIN; STAPHYLOCOCCUS-AUREUS; CREATININE CLEARANCE; MORBIDLY OBESE; VANCOMYCIN; THERAPY; BACTEREMIA; PHARMACOKINETICS AB STUDY OBJECTIVE Data are limited for antimicrobial outcomes in obese patients. This study investigated the safety and clinical outcomes of daptomycin therapy in a hospitalized obese population in the southeastern United States. DESIGN Multicenter retrospective cohort study. SETTING Thirteen hospitals in the southeastern United States. PATIENTS A total of 126 hospitalized adult obese patients (body mass index [BMI] more than 30 kg/m(2)) admitted from January 2005 through May 2010 who received daptomycin dosed on actual body weight for any indication for a minimum of 7 days. MEASUREMENTS AND MAIN RESULTS Primary safety outcomes included incidence of creatine phosphokinase (CPK) elevations more than 1000 units/L, more than 500 units/L, myalgias, and discontinuation of therapy due to adverse drug events (ADEs). Patients were stratified by BMI class (I, II, or III) for analyses. The average weight was 121 kg, and 39% of patients were considered morbidly obese. Factors associated with an increased risk of primary safety outcomes were assessed through regression analysis. Clinical effectiveness was evaluated as a secondary outcome. CPK elevations more than 1000 units/L occurred in 8.4% of evaluable patients and specifically in 1 (3.6%), 3 (10.3%), and 4 (10.5%) patients in BMI class I, II, and III, respectively (p=0.554). CPK elevations more than 500 units/L occurred in 13.7% of patients with no statistically significant difference noted across BMI classes. Discontinuation due to ADEs occurred in 8 patients (6.3%). One patient developed rhabdomyolysis on day 9 of therapy. Clinical effectiveness was documented in 71% of patients and was consistent across BMI classes. CONCLUSION Although elevations in CPK increased in high-risk obese patients on daptomycin, discontinuation rates due to ADEs remained low. Further evaluation in a prospective trial is warranted. C1 [Bookstaver, P. Brandon; Qureshi, Zaina P.; Caulder, Celeste R.] Univ S Carolina, South Carolina Coll Pharm, Dept Clin Pharm & Outcomes Sci, Columbia, SC 29208 USA. [Bland, Christopher M.] Dwight D Eisenhower Army Med Ctr, Dept Pharm, Ft Gordon, GA USA. [Faulkner-Fennell, Carmen M.] Greenville Univ Hosp Syst, Dept Pharm, Greenville, SC USA. [Sheldon, Margrit A.] St Josephs Candler Hosp, Dept Pharm, Savannah, GA USA. [Hartis, Charles] Forsyth Med Ctr, Dept Pharm, Winston Salem, NC USA. RP Bookstaver, PB (reprint author), Univ S Carolina, South Carolina Coll Pharm, Dept Clin Pharm & Outcomes Sci, 715 Sumter St, Columbia, SC 29208 USA. EM bookstaver@sccp.sc.edu FU Cubist Pharmaceuticals; Merck Co., Inc. FX P. B. Bookstaver receives research funding from Cubist Pharmaceuticals and Merck & Co., Inc. He is a prior member of the speaker's bureau at Merck & Co., Inc, and a member of the advisory board at Optimer Pharmaceuticals. C. M. Bland is a member of the speaker's bureau at Cubist Pharmaceuticals and a member of the advisory board at Optimer Pharmaceuticals. NR 44 TC 7 Z9 7 U1 0 U2 7 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0277-0008 EI 1875-9114 J9 PHARMACOTHERAPY JI Pharmacotherapy PD DEC PY 2013 VL 33 IS 12 BP 1322 EP 1330 DI 10.1002/phar.1298 PG 9 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA 297HQ UT WOS:000330246900013 PM 23712701 ER PT J AU Cole, GT Hung, CY Sanderson, SD Hurtgen, BJ Wuthrich, M Klein, BS Deepe, GS Ostroff, GR Levitz, SM AF Cole, Garry T. Hung, Chiung-Yu Sanderson, Sam D. Hurtgen, Brady J. Wuethrich, Marcel Klein, Bruce S. Deepe, George S. Ostroff, Gary R. Levitz, Stuart M. TI Novel Strategies to Enhance Vaccine Immunity against Coccidioidomycosis SO PLOS PATHOGENS LA English DT Article ID INFECTION; IMMITIS; DESIGN; CELLS; MICE; PEPTIDE; CD4(+) C1 [Cole, Garry T.; Hung, Chiung-Yu] Univ Texas San Antonio, Dept Biol, San Antonio, TX 78249 USA. [Cole, Garry T.; Hung, Chiung-Yu] Univ Texas San Antonio, South Texas Ctr Emerging Infect Dis, San Antonio, TX USA. [Sanderson, Sam D.] Univ Nebraska Med Ctr, Dept Pharmaceut Sci, Omaha, NE USA. [Hurtgen, Brady J.] US Army, Inst Surg Res, San Antonio, TX USA. [Wuethrich, Marcel; Klein, Bruce S.] Univ Wisconsin, Sch Med & Publ Hlth, Dept Pediat & Microbiol & Immunol, Madison, WI USA. [Deepe, George S.] Univ Cincinnati, Coll Med, Div Infect Dis, Cincinnati, OH USA. [Deepe, George S.] Vet Affairs Hosp, Cincinnati, OH USA. [Ostroff, Gary R.; Levitz, Stuart M.] Univ Massachusetts, Sch Med, Dept Med, Worcester, MA USA. RP Cole, GT (reprint author), Univ Texas San Antonio, Dept Biol, San Antonio, TX 78249 USA. EM garry.cole@utsa.edu FU National Institudes of Health [RO1 AI-071118] FX This work was supported by the National Institudes of Health with a grant (RO1 AI-071118) awarded to GTC. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 26 TC 6 Z9 6 U1 1 U2 1 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1553-7374 J9 PLOS PATHOG JI PLoS Pathog. PD DEC PY 2013 VL 9 IS 12 AR e1003768 DI 10.1371/journal.ppat.1003768 PG 4 WC Microbiology; Parasitology; Virology SC Microbiology; Parasitology; Virology GA 301MC UT WOS:000330535400013 PM 24367252 ER PT J AU Dutta, S Dlugosz, LS Drew, DR Ge, XP Ababacar, D Rovira, YI Moch, JK Shi, M Long, CA Foley, M Beeson, JG Anders, RF Miura, K Haynes, JD Batchelor, AH AF Dutta, Sheetij Dlugosz, Lisa S. Drew, Damien R. Ge, Xiopeng Ababacar, Diouf Rovira, Yazmin I. Moch, J. Kathleen Shi, Meng Long, Carole A. Foley, Michael Beeson, James G. Anders, Robin F. Miura, Kazutoyo Haynes, J. David Batchelor, Adrian H. TI Overcoming Antigenic Diversity by Enhancing the Immunogenicity of Conserved Epitopes on the Malaria Vaccine Candidate Apical Membrane Antigen-1 SO PLOS PATHOGENS LA English DT Article ID PLASMODIUM-FALCIPARUM MEROZOITES; GROWTH-INHIBITORY ANTIBODIES; CELL INVASION; DOMAIN-III; IN-VITRO; APICOMPLEXAN PARASITES; NEUTRALIZING ANTIBODY; ERYTHROCYTE INVASION; MEDIATED INHIBITION; MONOCLONAL-ANTIBODY AB Malaria vaccine candidate Apical Membrane Antigen-1 (AMA1) induces protection, but only against parasite strains that are closely related to the vaccine. Overcoming the AMA1 diversity problem will require an understanding of the structural basis of cross-strain invasion inhibition. A vaccine containing four diverse allelic proteins 3D7, FVO, HB3 and W2mef (AMA1 Quadvax or QV) elicited polyclonal rabbit antibodies that similarly inhibited the invasion of four vaccine and 22 non-vaccine strains of P. falciparum. Comparing polyclonal anti-QV with antibodies against a strain-specific, monovalent, 3D7 AMA1 vaccine revealed that QV induced higher levels of broadly inhibitory antibodies which were associated with increased conserved face and domain-3 responses and reduced domain-2 response. Inhibitory monoclonal antibodies (mAb) raised against the QV reacted with a novel cross-reactive epitope at the rim of the hydrophobic trough on domain-1; this epitope mapped to the conserved face of AMA1 and it encompassed the 1e-loop. MAbs binding to the 1e-loop region (1B10, 4E8 and 4E11) were similar to 10-fold more potent than previously characterized AMA1-inhibitory mAbs and a mode of action of these 1e-loop mAbs was the inhibition of AMA1 binding to its ligand RON2. Unlike the epitope of a previously characterized 3D7-specific mAb, 1F9, the 1e-loop inhibitory epitope was partially conserved across strains. Another novel mAb, 1E10, which bound to domain-3, was broadly inhibitory and it blocked the proteolytic processing of AMA1. By itself mAb 1E10 was weakly inhibitory but it synergized with a previously characterized, strain-transcending mAb, 4G2, which binds close to the hydrophobic trough on the conserved face and inhibits RON2 binding to AMA1. Novel inhibition susceptible regions and epitopes, identified here, can form the basis for improving the antigenic breadth and inhibitory response of AMA1 vaccines. Vaccination with a few diverse antigenic proteins could provide universal coverage by redirecting the immune response towards conserved epitopes. C1 [Dutta, Sheetij; Dlugosz, Lisa S.; Rovira, Yazmin I.; Moch, J. Kathleen; Shi, Meng; Haynes, J. David; Batchelor, Adrian H.] Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. [Drew, Damien R.; Beeson, James G.] Burnet Inst, Melbourne, Vic, Australia. [Ge, Xiopeng; Foley, Michael; Anders, Robin F.] La Trobe Univ, Dept Biochem, Bundoora, Vic 3086, Australia. [Ababacar, Diouf; Long, Carole A.; Miura, Kazutoyo] NIH, Lab Malaria & Vector Res, Rockville, MD USA. RP Dutta, S (reprint author), Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. EM sheetij.dutta.civ@mail.mil FU PATH Malaria Vaccine Initiative; US Agency for International Development Malaria Vaccine Program; Institute National Health and Medical Research Council of Australia; Australian Research Council; Victorian State Government Operational Infrastructure Support grant; Intramural Program of NIAID FX The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Funding for the WRAIR and La Trobe University was provided by PATH Malaria Vaccine Initiative and US Agency for International Development Malaria Vaccine Program. Burnet Institute was funded by Institute National Health and Medical Research Council of Australia; Australian Research Council; and a Victorian State Government Operational Infrastructure Support grant. The NIH studies were supported in part by the Intramural Program of NIAID and the PATH Malaria Vaccine Initiative. NR 88 TC 35 Z9 35 U1 0 U2 6 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1553-7374 J9 PLOS PATHOG JI PLoS Pathog. PD DEC PY 2013 VL 9 IS 12 AR e1003840 DI 10.1371/journal.ppat.1003840 PG 17 WC Microbiology; Parasitology; Virology SC Microbiology; Parasitology; Virology GA 301MC UT WOS:000330535400059 PM 24385910 ER PT J AU Benson, J Kovalenko, I Boukhalfa, S Lashmore, D Sanghadasa, M Yushin, G AF Benson, Jim Kovalenko, Igor Boukhalfa, Sofiane Lashmore, David Sanghadasa, Mohan Yushin, Gleb TI Multifunctional CNT-Polymer Composites for Ultra-Tough Structural Supercapacitors and Desalination Devices SO ADVANCED MATERIALS LA English DT Article DE nanocomposite; supercapacitor; smart-textile; mesoporous; carbon nanotube ID WALLED CARBON NANOTUBES; MECHANICAL-PROPERTIES; POLYANILINE; ELECTRODES; PERFORMANCE; BATTERIES; NANOCOMPOSITES; REINFORCEMENT; CONDUCTIVITY; DEPOSITION C1 [Benson, Jim; Kovalenko, Igor; Boukhalfa, Sofiane; Yushin, Gleb] Georgia Inst Technol, Sch Mat Sci & Engn, Atlanta, GA 30332 USA. [Lashmore, David] Univ New Hampshire, Coll Engn & Phys Sci, Mat Sci Program, Durham, NH 03824 USA. [Sanghadasa, Mohan] US Army RDECOM, Weap Dev & Integrat Directorate, Ctr Engn, Redstone Arsenal, AL 35898 USA. RP Yushin, G (reprint author), Georgia Inst Technol, Sch Mat Sci & Engn, Atlanta, GA 30332 USA. EM yushin@gatech.edu RI Yushin, Gleb/B-4529-2013 OI Yushin, Gleb/0000-0002-3274-9265 FU Aviation & Missile Research Development, Engineering Center, US Army RDECOM FX This work was supported by the Aviation & Missile Research Development, Engineering Center, US Army RDECOM. Authors Jim Benson, Igor Kovalenko, and Sofiane Boukhalfa contributed equally to this work. NR 61 TC 51 Z9 51 U1 21 U2 201 PU WILEY-V C H VERLAG GMBH PI WEINHEIM PA POSTFACH 101161, 69451 WEINHEIM, GERMANY SN 0935-9648 EI 1521-4095 J9 ADV MATER JI Adv. Mater. PD DEC PY 2013 VL 25 IS 45 BP 6625 EP 6632 DI 10.1002/adma.201301317 PG 8 WC Chemistry, Multidisciplinary; Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied; Physics, Condensed Matter SC Chemistry; Science & Technology - Other Topics; Materials Science; Physics GA 295HI UT WOS:000330106800019 PM 23970397 ER PT J AU Stumpf, RM Wilson, BA Rivera, A Yildirim, S Yeoman, CJ Polk, JD White, BA Leigh, SR AF Stumpf, Rebecca M. Wilson, Brenda A. Rivera, Angel Yildirim, Suleyman Yeoman, Carl J. Polk, John D. White, Bryan A. Leigh, Steven R. TI The Primate Vaginal Microbiome: Comparative Context and Implications for Human Health and Disease SO AMERICAN JOURNAL OF PHYSICAL ANTHROPOLOGY LA English DT Article DE microbiome; primates; evolution; next-generation sequencing ID SEXUALLY-TRANSMITTED-DISEASES; B STREPTOCOCCAL DISEASE; HUMAN GUT MICROBIOME; RNA GENE-SEQUENCES; BACTERIAL VAGINOSIS; POSTMENOPAUSAL WOMEN; INFECTIOUS-DISEASES; POPULATION BIOLOGY; MENSTRUAL-CYCLE; MATING SYSTEMS AB The primate body hosts trillions of microbes. Interactions between primate hosts and these microbes profoundly affect primate physiology, reproduction, health, survival, and ultimately, evolution. It is increasingly clear that primate health cannot be understood fully without knowledge of host-microbial interactions. Our goals here are to review what is known about microbiomes of the female reproductive tract and to explore several factors that influence variation within individuals, as well as within and between primate species. Much of our knowledge of microbial variation derives from studies of humans, and from microbes located in nonreproductive regions (e.g., the gut). We review work suggesting that the vaginal microbiota affects female health, fecundity, and pregnancy outcomes, demonstrating the selective potential for these agents. We explore the factors that correlate with microbial variation within species. Initial colonization by microbes depends on the manner of birth; most microbial variation is structured by estrogen levels that change with age (i.e., at puberty and menopause) and through the menstrual cycle. Microbial communities vary by location within the vagina and can depend on the sampling methods used (e.g., swab, lavage, or pap smear). Interindividual differences also exist, and while this variation is not completely understood, evidence points more to differences in estrogen levels, rather than differences in external physical environment. When comparing across species, reproductive-age humans show distinct microbial communities, generally dominated by Lactobacillus, unlike other primates. We develop evolutionary hypotheses to explain the marked differences in microbial communities. While much remains to be done to test these hypotheses, we argue that the ample variation in primate mating and reproductive behavior offers excellent opportunities to evaluate host-microbe coevolution and adaptation. Am J Phys Anthropol 57:119-134, 2013. (c) 2013 Wiley Periodicals, Inc. C1 [Stumpf, Rebecca M.; Polk, John D.] Univ Illinois, Dept Anthropol, Urbana, IL 61801 USA. [Stumpf, Rebecca M.; Wilson, Brenda A.; Rivera, Angel; White, Bryan A.; Leigh, Steven R.] Univ Illinois, Inst Genom Biol, Urbana, IL 61801 USA. [Wilson, Brenda A.] Univ Illinois, Dept Microbiol, Urbana, IL 61801 USA. [Yildirim, Suleyman] Walter Reed Army Inst Res, Silver Spring, MD USA. [Yeoman, Carl J.] Montana State Univ, Dept Anim & Range Sci, Bozeman, MT 59717 USA. [Leigh, Steven R.] Univ Colorado, Dept Anthropol, Boulder, CO 80309 USA. RP Stumpf, RM (reprint author), Univ Illinois, Dept Anthropol, 109 Davenport Hall,607 S Mathews Ave, Urbana, IL 61801 USA. EM rstumpf@illinois.edu OI Yildirim, Suleyman/0000-0002-2752-1223; LEIGH, STEVEN/0000-0001-6844-7122 FU National Science Foundation [BCS-08-20709, BCS-09-35374]; University of Illinois Research Board; University of Illinois Institute for Genomic Biology; University of Illinois - Carle Hospital Translational Research Grant FX Grant sponsor: National Science Foundation (BCS-08-20709, BCS-09-35374); The University of Illinois Research Board, the University of Illinois Institute for Genomic Biology, and the University of Illinois - Carle Hospital Translational Research Grant. NR 208 TC 20 Z9 20 U1 7 U2 55 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0002-9483 EI 1096-8644 J9 AM J PHYS ANTHROPOL JI Am. J. Phys. Anthropol. PD DEC PY 2013 VL 152 SU 57 BP 119 EP 134 DI 10.1002/ajpa.22395 PG 16 WC Anthropology; Evolutionary Biology SC Anthropology; Evolutionary Biology GA 296JL UT WOS:000330181100006 PM 24166771 ER PT J AU Miller, AK Harrell, E Ye, L Baptiste-Brown, S Kleim, JP Ohrt, C Duparc, S Mohrle, JJ Webster, A Stinnett, S Hughes, A Griffith, S Beelen, AP AF Miller, Ann K. Harrell, Emma Ye, Li Baptiste-Brown, Sharon Kleim, Jorg-Peter Ohrt, Colin Duparc, Stephan Moehrle, Joerg J. Webster, Alison Stinnett, Sandra Hughes, Arlene Griffith, Sandy Beelen, Andrew P. TI Pharmacokinetic interactions and safety evaluations of coadministered tafenoquine and chloroquine in healthy subjects SO BRITISH JOURNAL OF CLINICAL PHARMACOLOGY LA English DT Article DE chloroquine; malaria; pharmacokinetics; radical cure; tafenoquine ID PLASMODIUM-VIVAX MALARIA; DOUBLE-BLIND; PRIMAQUINE; FALCIPARUM; 8-AMINOQUINOLINES; PROPHYLAXIS; EFFICACY; THERAPY; RELAPSE; TRIAL AB AIMS The long-acting 8-aminoquinoline tafenoquine (TQ) coadministered with chloroquine (CQ) may radically cure Plasmodium vivax malaria. Coadministration therapy was evaluated for a pharmacokinetic interaction and for pharmacodynamic, safety and tolerability characteristics. METHODS Healthy subjects, 18-55 years old, without documented glucose-6-phosphate dehydrogenase deficiency, received CQ alone (days 1-2, 600 mg; and day 3, 300 mg), TQ alone (days 2 and 3, 450 mg) or coadministration therapy (day 1, CQ 600 mg; day 2, CQ 600 mg + TQ 450 mg; and day 3, CQ 300 mg + TQ 450 mg) in a randomized, double-blind, parallel-group study. Blood samples for pharmacokinetic and pharmacodynamic analyses and safety data, including electrocardiograms, were collected for 56 days. RESULTS The coadministration of CQ + TQ had no effect on TQ AUC(0-tr), AUC(0-infinity), T-max or t(1/2). The 90% confidence intervals of CQ + TQ vs. TQ for AUC(0-tr), AUC(0-infinity) and t(1/2) indicated no drug interaction. On day 2 of CQ + TQ coadministration, TQ Cmax and AUC(0-24) increased by 38% (90% confidence interval 1.27, 1.64) and 24% (90% confidence interval 1.04, 1.46), respectively. The pharmacokinetics of CQ and its primary metabolite desethylchloroquine were not affected by TQ. Coadministration had no clinically significant effect on QT intervals and was well tolerated. CONCLUSIONS No clinically significant safety or pharmacokinetic/ pharmacodynamic interactions were observed with coadministered CQ and TQ in healthy subjects. C1 [Miller, Ann K.; Baptiste-Brown, Sharon] GSK, King Of Prussia, PA 19406 USA. [Harrell, Emma; Kleim, Jorg-Peter; Webster, Alison] GSK, Stockley Pk, Uxbridge, Middx, England. [Ye, Li] GSK, Collegeville, PA USA. [Ohrt, Colin] Walter Reed Army Inst Res, Silver Spring, MD USA. [Duparc, Stephan; Moehrle, Joerg J.] Med Malaria Venture, Geneva, Switzerland. [Stinnett, Sandra; Hughes, Arlene; Griffith, Sandy] GSK, Res Triangle Pk, NC USA. RP Miller, AK (reprint author), GSK, 709 Swedeland Rd, King Of Prussia, PA 19406 USA. EM ann.k.miller@gsk.com FU GlaxoSmithKline; Medicines for Malaria Venture; GSK; MMV [NCT00871156] FX GlaxoSmithKline and Medicines for Malaria Venture provided financial support for the study.; Funding for this study was provided by GSK and MMV (NCT00871156). All listed authors meet the criteria for authorship set forth by the International Committee for Medical Journal Editors. The authors wish to acknowledge Khadeeja Mohamed for input into the statistical design and analysis of the study. Editorial support in the form of development of the manuscript first draft, assembling tables and figures, collating author comments and referencing was provided by Jane Saiers, PhD at The WriteMedicine, Inc. Editorial suggestions to draft versions of this paper, assembling tables and figures, collating author comments and copyediting was provided by Tracey Fine, MS, ELS at Fine Biomedical Communications, Inc. All editorial support was funded by GSK. This manuscript was reviewed by the Walter Reed Army Institute for Research and the United States Army Medical Research and Material Command. There is no objection to its publication or dissemination. The opinions expressed herein are those of the authors and do not necessarily reflect the official policy, position or opinions of the Department of the Army, the Department of Defense or the US Government. NR 24 TC 9 Z9 9 U1 1 U2 4 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0306-5251 EI 1365-2125 J9 BRIT J CLIN PHARMACO JI Br. J. Clin. Pharmacol. PD DEC PY 2013 VL 76 IS 6 BP 858 EP 867 DI 10.1111/bcp.12160 PG 10 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA 296IQ UT WOS:000330178900003 PM 23701202 ER PT J AU Glassberg, E Nadler, R Gendler, S Abramovich, A Spinella, PC Gerhardt, RT Holcomb, JB Kreiss, Y AF Glassberg, Elon Nadler, Roy Gendler, Sami Abramovich, Amir Spinella, Philip C. Gerhardt, Robert T. Holcomb, John B. Kreiss, Yitshak TI FREEZE-DRIED PLASMA AT THE POINT OF INJURY: FROM CONCEPT TO DOCTRINE SO SHOCK LA English DT Review DE Plasma; freeze-dried plasma; resuscitative fluid; pre hospital; point-of-injury care ID FRESH-FROZEN PLASMA; RED-BLOOD-CELL; DAMAGE-CONTROL RESUSCITATION; TRAUMA-ASSOCIATED COAGULOPATHY; REQUIRING MASSIVE TRANSFUSION; FLUID RESUSCITATION; PREHOSPITAL PLASMA; LYOPHILIZED PLASMA; HEMORRHAGIC-SHOCK; UNITED-STATES AB While early plasma transfusion for the treatment of patients with ongoing major hemorrhage is widely accepted as part of the standard of care in the hospital setting, logistic constraints have limited its use in the out-of-hospital setting. Freeze-dried plasma (FDP), which can be stored at ambient temperatures, enables early treatment in the out-of-hospital setting. Point-of-injury plasma transfusion entails several significant advantages over currently used resuscitation fluids, including the avoidance of dilutional coagulopathy, by minimizing the need for crystalloid infusion, beneficial effects on endothelial function, physiological pH level, and better maintenance of intravascular volume compared with crystalloid-based solutions. The Israel Defense Forces Medical Corps policy is that plasma is the resuscitation fluid of choice for selected, severely wounded patients and has thus included FDP as part of its armamentarium for use at the point of injury by advanced life savers, across the entire military. We describe the clinical rationale behind the use of FDP at the point-of-injury, the drafting of the administration protocol now being used by Israel Defense Forces advanced life support providers, the process of procurement and distribution, and preliminary data describing the first casualties treated with FDP at the point of injury. It is our hope that others will be able to learn from our experience, thus improving trauma casualty care around the world. C1 [Glassberg, Elon; Nadler, Roy; Gendler, Sami; Abramovich, Amir; Kreiss, Yitshak] Surg Gen Headquarters, IL-02149 Israel Def Forces, Israel. [Glassberg, Elon; Nadler, Roy; Gendler, Sami; Abramovich, Amir; Kreiss, Yitshak] Hebrew Univ Jerusalem, Dept Mil Med, Jerusalem, Israel. [Spinella, Philip C.] Washington Univ, Dept Pediat, Div Crit Care, St Louis, MO 63130 USA. [Spinella, Philip C.; Gerhardt, Robert T.] US Army Inst Surg Res, Ft Sam Houston, TX USA. [Holcomb, John B.] Univ Texas Hlth Sci Ctr Houston, Ctr Translat Injury Res, Div Acute Care Surg, Dept Surg, Houston, TX 77030 USA. RP Glassberg, E (reprint author), Surg Gen Headquarters, Med Corps, Trauma & Combat Med Branch, Mil POB 02149, IL-02149 Israel Def Forces, Israel. EM idf_trauma@idf.gov.il NR 61 TC 38 Z9 38 U1 1 U2 8 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1073-2322 EI 1540-0514 J9 SHOCK JI Shock PD DEC PY 2013 VL 40 IS 6 BP 444 EP 450 DI 10.1097/SHK.0000000000000047 PG 7 WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System & Cardiology GA 297IL UT WOS:000330249000002 PM 24089000 ER PT J AU Carbone, JW Margolis, LM McClung, JP Cao, JJ Murphy, NE Sauter, ER Combs, GF Young, AJ Pasiakos, SM AF Carbone, John W. Margolis, Lee M. McClung, James P. Cao, Jay J. Murphy, Nancy E. Sauter, Edward R. Combs, Gerald F., Jr. Young, Andrew J. Pasiakos, Stefan M. TI Effects of energy deficit, dietary protein, and feeding on intracellular regulators of skeletal muscle proteolysis SO FASEB JOURNAL LA English DT Article DE ubiquitin proteasome; caspase-3; negative energy balance; high-protein diets ID GASTRIC-CANCER PATIENTS; FAT-FREE MASS; ENDURANCE EXERCISE; CATABOLIC CONDITIONS; GENE-EXPRESSION; WEIGHT-LOSS; PROTEASOME; RESPONSES; PATHWAY; SUPPLEMENTATION AB This study was undertaken to characterize the ubiquitin proteasome system (UPS) response to varied dietary protein intake, energy deficit (ED), and consumption of a mixed meal. A randomized, controlled trial of 39 adults consuming protein at 0.8 (recommended dietary allowance [RDA]), 1.6 (2x-RDA), or 2.4 (3x-RDA) g.kg(-1).d(-1) for 31 d. A 10-d weight maintenance (WM) period was followed by 21 d of 40% ED. Ubiquitin (Ub)-mediated proteolysis and associated gene expression were assessed in the postabsorptive (fasted) and postprandial (fed; 480 kcal, 20 g protein) states after WM and ED by using muscle biopsies, fluorescence-based assays, immunoblot analysis, and real-time qRT-PCR. In the assessment of UPS responses to varied protein intakes, ED, and feeding, the RDA, WM, and fasted measures served as appropriate controls. ED resulted in the up-regulation of UPS-associated gene expression, as mRNA expression of the atrogenes muscle RING finger-1 (MuRF1) and atrogin-1 were 1.2- and 1.3-fold higher (P<0.05) for ED than for WM. However, mixed-meal consumption attenuated UPS-mediated proteolysis, independent of energy status or dietary protein, as the activities of the 26S proteasome subunits beta 1, beta 2, and beta 5 were lower (P<0.05) for fed than for fasted. Muscle protein ubiquitylation was also 45% lower (P<0.05) for fed than for fasted, regardless of dietary protein and energy manipulations. Independent of habitual protein intake and despite increased MuRF1 and atrogin-1 mRNA expression during ED, consuming a protein-containing mixed meal attenuates Ub-mediated proteolysis. C1 [Carbone, John W.] Eastern Michigan Univ, Sch Hlth Sci, Ypsilanti, MI 48197 USA. [Margolis, Lee M.; McClung, James P.; Murphy, Nancy E.; Young, Andrew J.; Pasiakos, Stefan M.] US Army Res Inst Environm Med, Mil Nutr Div, Natick, MA 01760 USA. [Cao, Jay J.; Sauter, Edward R.; Combs, Gerald F., Jr.] ARS, Grand Forks Human Nutr Res Ctr, USDA, Grand Forks, ND USA. [Sauter, Edward R.] Univ N Dakota, Sch Med & Hlth Sci, Grand Forks, ND 58201 USA. RP Pasiakos, SM (reprint author), US Army Res Inst Environm Med, Mil Nutr Div, 15 Kansas St,Bldg 42, Natick, MA 01760 USA. EM stefan.pasiakos@us.army.mil RI McClung, James/A-1989-2009; Pasiakos, Stefan/E-6295-2014; OI Pasiakos, Stefan/0000-0002-5378-5820; , Lee/0000-0002-0652-1304 FU U.S. Army Medical Research and Material Command (USAMRMC); USDA, Agricultural Research Service (ARS); Eastern Michigan University College of Health and Human Services; Dairy Research Institute; USDA; USAMRMC; USDA, ARS [58-1950-7-707] FX The authors thank the volunteers who participated in this research experiment and LuAnn Johnson [U.S. Department of Agriculture (USDA) Grand Forks Human Nutrition Research Center, Grand Forks, SD, USA] for significant contributions to the data analysis. The study was supported by the U.S. Army Medical Research and Material Command (USAMRMC); the USDA, Agricultural Research Service (ARS); and the Eastern Michigan University College of Health and Human Services. S. M. P. reported that his institution received a grant from the Dairy Research Institute for work outside this publication. E. R. S. reported that his institution received a grant and travel support from the USDA for work associated with this publication. E. R. S. is a consultant for Halo Health, has received royalties for book editorship, and has been granted a patent. J.P.M. reported that his institution received a grant from the USAMRMC for work outside this publication. The other authors report no conflicts of interest. The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the U. S. Army or the U. S. Department of Defense. Any citations of commercial organizations and trade names in this report do not constitute an official Department of the Army endorsement of approval of the products or services of these organizations. This material is based on work supported by the USDA, ARS, under agreement 58-1950-7-707. Any opinions, findings, conclusion, or recommendations expressed in this publication are those of the authors and do not necessarily reflect the view of the USDA. This trial is registered at ClinicalTrials.gov (http://www.clinicaltrials.gov) as number NCT01292395. NR 36 TC 12 Z9 12 U1 0 U2 14 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 EI 1530-6860 J9 FASEB J JI Faseb J. PD DEC PY 2013 VL 27 IS 12 BP 5104 EP 5111 DI 10.1096/fj.13-239228 PG 8 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 293UK UT WOS:000329999000042 PM 23965841 ER PT J AU De Gregorio, BA Weatherhead, PJ Tuberville, TD Sperry, JH AF GreGorio, Brett A. De Weatherhead, Patrick. J. Tuberville, Tracey D. Sperry, Jinelle H. TI TIME IN CAPTIVITY AFFECTS FORAGING BEHAVIOR OF RATSNAKES: IMPLICATIONS FOR TRANSLOCATION SO HERPETOLOGICAL CONSERVATION AND BIOLOGY LA English DT Article DE conservation; Elaphe obsoleta; prey detection; reintroduction; repatriation; snakes ID CONSERVATION TOOL; VISUAL-STIMULI; SURVIVAL; SNAKES; WILD; INDIVIDUALS; ENRICHMENT; EXPERIENCE; RESPONSES; ANIMALS AB As wildlife populations decline or disappear, wildlife professionals are using management tools such as translocation to maintain viable populations, often with mixed results. Wild-to-wild translocations are often more successful than when captive animals are released, raising concerns that captivity may have deleterious effects on animals. although the effects of captivity have been documented on a generational time-scale, effects within the lifetime of an individual have received much less attention. here we examine how time in captivity affects foraging behavior of wild-caught ratsnakes (Elaphe obsoleta). The longer ratsnakes had been in captivity, the less successful and slower they were to react to prey in a simple laboratory discrimination task. snakes that had been captive for a year or more performed no better than expected by chance. Captivity-induced degradation of ecologically important behaviors provides a potential mechanism underlying the poor performance of animals that are released into the wild following prolonged captivity. our results also suggest that research using captive snakes may not always document behaviors representative of wild snakes. C1 [GreGorio, Brett A. De; Weatherhead, Patrick. J.; Sperry, Jinelle H.] Univ Illinois, Dept Nat Resources & Environm Sci, Urbana, IL 61801 USA. [GreGorio, Brett A. De; Tuberville, Tracey D.] Univ Georgia, Savannah River Ecol Lab, Aiken, SC 29802 USA. [Sperry, Jinelle H.] Engineer Res & Dev Ctr, Champaign, IL 61826 USA. RP De Gregorio, BA (reprint author), Univ Illinois, Dept Nat Resources & Environm Sci, 1102 S Goodwin Ave, Urbana, IL 61801 USA. EM Bdegrego@illinois.edu FU Construction Engineering Research Laboratory of the Engineer Research Development Center (ERDC); Department of Energy to the University of Georgia Research Foundation [DE-FC09-07SR22506] FX Funding for this project was provided by the Construction Engineering Research Laboratory of the Engineer Research Development Center (ERDC). We thank Tim Hayden for assistance in arranging funding. This work would not have been possible without the generosity and meticulous record-keeping of Sean Poppy and Angela Tucker in the SREL outreach program. Eric Nordberg, Mary Mack Gray, Brian Metts, Ashley Smith, Patrick Barnhart, Patrick Roberts, Caitlin Kupar, and Phil Vogrinc assisted in snake capture and husbandry. Partial support for manuscript preparation by TDT and use of animal facilities was made possible by Award Number DE-FC09-07SR22506 from Department of Energy to the University of Georgia Research Foundation. Animals were collected under South Carolina Department of Natural Resources permits #G-11-03 and 23-2012A. Animal procedures conformed to permits approved by the University of Illinois (IACUC #11054) and University of Georgia (AUP #A2011 04-007-Y2-A0). NR 38 TC 3 Z9 4 U1 6 U2 46 PU HERPETOLOGICAL CONSERVATION & BIOLOGY PI CORVALLIS PA C/O R BRUCE BURY, USGS FOREST & RANGELAND, CORVALLIS, OR 00000 USA SN 2151-0733 EI 1931-7603 J9 HERPETOL CONSERV BIO JI Herpetol. Conserv. Biol. PD DEC PY 2013 VL 8 IS 3 BP 581 EP 590 PG 10 WC Zoology SC Zoology GA 294KD UT WOS:000330043600008 ER PT J AU Huh, J Krueger, CA Medvecky, MJ Hsu, JR AF Huh, Jeannie Krueger, Chad A. Medvecky, Michael J. Hsu, Joseph R. CA Skeletal Trauma Res Consortium TI Medial Elbow Exposure for Coronoid Fractures: FCU-Split Versus Over-the-Top SO JOURNAL OF ORTHOPAEDIC TRAUMA LA English DT Article DE medial elbow; surgical exposure; coronoid anteromedial facet fracture; Hotchkiss Over-the-Top; FCU-Splitting ID ULNAR COLLATERAL LIGAMENT; FLEXOR CARPI ULNARIS; ANTEROMEDIAL FACET; STABILITY AB Objective:The optimal exposure interval for anteromedial coronoid fractures is unknown. The purpose of this study was to quantitatively compare the osseous and ligamentous exposure of the medial elbow using the flexor carpi ulnaris (FCU)-Splitting and Hotchkiss Over-the-Top approaches.Methods:Forty surgical approaches were performed on 20 fresh-frozen cadaveric elbows using a randomized crossover design. Access to key anatomic landmarks [anteromedial facet, coronoid tip, sublime tubercle/anterior bundle of the medial collateral ligament (MCL), posterior bundle of the MCL, and radial head] was assessed. A calibrated digital image was taken from the surgeon's perspective of each approach, and these images were analyzed using a software program, ImageJ (NIH), to calculate the surface area of osseous structures exposed.Results:The average surface area exposed was 3 times greater with the FCU-Splitting approach (13.3 cm(2)) compared with the Hotchkiss Over-the-Top approach (4.4 cm(2)) (P < 0.0001). All key anatomic landmarks were directly visualized with the FCU-Splitting approach in each specimen. Visualization of the sublime tubercle/anterior bundle of the MCL and posterior bundle of the MCL was unobtainable with the Hotchkiss approach in 17 (85%) and 20 (100%) specimens, respectively. There were no statistically significant correlations between exposure and sequence of dissection, specimen age, gender, or laterality.Conclusions:The FCU-Splitting approach provides more extensive exposure of the anteromedial coronoid and proximal ulna and the medial ligamentous structures than the Hotchkiss Over-the-Top approach. C1 [Huh, Jeannie; Krueger, Chad A.] Brooke Army Med Ctr, Dept Orthopaed Surg & Rehabil, Ft Sam Houston, TX 78234 USA. [Medvecky, Michael J.] Yale Univ, Sch Med, Dept Orthopaed & Rehabil, New Haven, CT 06510 USA. [Hsu, Joseph R.] USAISR, Ft Sam Houston, TX USA. RP Krueger, CA (reprint author), Brooke Army Med Ctr, Bldg 3600,3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM chad.krueger@amedd.army.mil FU Geneva Foundation FX J. R. Hsu is currently receiving grant funding from the Geneva Foundation. For the remaining authors, none were declared. NR 25 TC 12 Z9 14 U1 0 U2 6 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0890-5339 EI 1531-2291 J9 J ORTHOP TRAUMA JI J. Orthop. Trauma PD DEC PY 2013 VL 27 IS 12 BP 730 EP 734 DI 10.1097/BOT.0b013e31828ba91c PG 5 WC Orthopedics; Sport Sciences SC Orthopedics; Sport Sciences GA 292YM UT WOS:000329938600019 PM 23412510 ER PT J AU Walia, HK Shalhoub, G Ramsammy, V Harrington, M Thornton, JD Auckley, D AF Walia, Harneet K. Shalhoub, George Ramsammy, Verai Harrington, Michael Thornton, J. Daryl Auckley, Dennis TI Symptoms of Restless Legs Syndrome in a Palliative Care Population: Frequency and impact SO JOURNAL OF PALLIATIVE CARE LA English DT Article DE restless legs syndrome; palliative care; quality of life ID QUALITY-OF-LIFE; GENERAL-POPULATION; DOUBLE-BLIND; SYNDROME RLS; PREVALENCE; VALIDATION; DIAGNOSIS; HEALTH; QUESTIONNAIRE; EPIDEMIOLOGY AB Objectives: We hypothesized that restless legs syndrome (RLS) would be common and associated with impaired quality of life (QOL) among palliative care outpatients. Methods: 76 palliative care clinic patients completed the National Institutes of Health restless legs syndrome (NIH-RLS) screening questionnaire. Questionnaire data was also gathered on RLS severity and RLS-related QOL, and the Short Form Health Survey (SF-12) was used to measure QOL. Analysis was performed for associations between RLS categorization and QOL measures. Results: 31 patients (40.8 percent) met criteria for RLS. RLS-positive patients had moderate-to-severe RLS symptoms and impaired RLS-specific QOL. RLS-positive patients scored lower on the mental component of the SF-12 (39 +/- 11 versus 45 +/- 12, p=0.03), though not on the physical component. In a multivariate regression analysis, higher levels of RLS severity had 2-point lower SF-12 mental component scores compared to lower levels of RLS severity (p=0.04), with no difference in physical component scores (p=0.47). Conclusion: RLS appears common in palliative care outpatients and is associated with impairments in QOL. C1 [Ramsammy, Verai; Auckley, Dennis] Case Western Reserve Univ, Div Pulm Crit Care & Sleep Med, MetroHlth Med Ctr, Cleveland, OH 44109 USA. [Walia, Harneet K.] Cleveland Clin Fdn, Ctr Sleep Disorders, Cleveland, OH 44195 USA. [Shalhoub, George] Womack Army Med Ctr, Div Internal Med, Ft Bragg, NC USA. [Harrington, Michael] Case Western Reserve Univ, Div Palliat Care Med, MetroHlth Med Ctr, Cleveland, OH 44109 USA. [Thornton, J. Daryl] Case Western Reserve Univ, Div Pulm Crit Care & Sleep Med, MetroHlth Med Ctr, Ctr Reducing Hlth Dispar, Cleveland, OH 44109 USA. RP Auckley, D (reprint author), Case Western Reserve Univ, Div Pulm Crit Care & Sleep Med, MetroHlth Med Ctr, 2500 MetroHlth Dr, Cleveland, OH 44109 USA. EM dauckley@metrohealth.org FU Teva Pharmaceuticals FX Harneet Walia, MD, George Shalhoub, MD, Verai Ramsammy, MD, Michael Harrington, MD, and J. Daryl Thornton, MD, MPH, have no actual or potential conflict of interest related to this study. Dennis Auckley, MD, has received research equipment from ResMed Corporation and receives grant funding from Teva Pharmaceuticals. These items of support are not related to this study. NR 34 TC 0 Z9 0 U1 0 U2 0 PU CENTRE RECHERCHE INSTITUT UNIV GERIATRIE MONTREAL PI MONTREAL PA 4565 CHEMIN QUEEN MARY, MONTREAL, QUEBEC H3W 1W5, CANADA SN 0825-8597 J9 J PALLIAT CARE JI J. Palliative Care PD WIN PY 2013 VL 29 IS 4 BP 210 EP 216 PG 7 WC Health Care Sciences & Services; Health Policy & Services; Public, Environmental & Occupational Health SC Health Care Sciences & Services; Public, Environmental & Occupational Health GA 293EG UT WOS:000329953600003 PM 24601071 ER PT J AU Linton, YM Pecor, JE Porter, CH Mitchell, LB Garzon-Moreno, A Foley, DH Pecor, DB Wilkerson, RC AF Linton, Yvonne-Marie Pecor, James E. Porter, Charles H. Mitchell, Luke Brett Garzon-Moreno, Andres Foley, Desmond H. Pecor, David Brooks Wilkerson, Richard C. TI Mosquitoes of eastern Amazonian Ecuador: biodiversity, bionomics and barcodes SO MEMORIAS DO INSTITUTO OSWALDO CRUZ LA English DT Article DE Ecuador; Amazon; Culicidae; DNA barcodes; species list; habitat ID ALLIED TAXA DIPTERA; LIFE STAGES; NEOTYPE DESIGNATION; MORPHOLOGICAL DATA; AEDINI DIPTERA; SOUTH-AMERICA; CULICIDAE; ANOPHELES; CLASSIFICATION; PHYLOGENY AB Two snapshot surveys to establish the diversity and ecological preferences of mosquitoes (Diptera: Culicidae) in the terra firme primary rain forest surrounding the Tiputini Biodiversity Station in the UNESCO Yasun Biosphere Reserve of eastern Amazonian Ecuador were carried out in November 1998 and May 1999. The mosquito fauna of this region is poorly known; the focus of this study was to obtain high quality link-reared specimens that could be used to unequivocally confirm species level diversity through integrated systematic study of all life stages and DNA sequences. A total of 2,284 specimens were preserved; 1,671 specimens were link-reared with associated immature exuviae, all but 108 of which are slide mounted. This study identified 68 unique taxa belonging to 17 genera and 27 subgenera. Of these, 12 are new to science and 37 comprise new country records. DNA barcodes [ 658-bp of the mtDNA cytochrome c oxidase (COI) I gene] are presented for 58 individuals representing 20 species and nine genera. DNA barcoding proved useful in uncovering and confirming new species and we advocate an integrated systematics approach to biodiversity studies in future. Associated bionomics of all species collected are discussed. An updated systematic checklist of the mosquitoes of Ecuador (n = 179) is presented for the first time in 60 years. C1 [Linton, Yvonne-Marie; Pecor, James E.; Foley, Desmond H.; Pecor, David Brooks; Wilkerson, Richard C.] Walter Reed Army Inst Res, Entomol Branch, Silver Spring, MD 20910 USA. [Linton, Yvonne-Marie; Pecor, James E.; Mitchell, Luke Brett; Garzon-Moreno, Andres; Foley, Desmond H.; Pecor, David Brooks] Smithsonian Inst, Museum Support Ctr, Walter Reed Biosystemat Unit, Suitland, MD USA. [Porter, Charles H.] Ctr Dis Control & Prevent, Atlanta, GA USA. [Wilkerson, Richard C.] Smithsonian Inst, Dept Entomol, Washington, DC 20560 USA. RP Linton, YM (reprint author), Walter Reed Army Inst Res, Entomol Branch, Silver Spring, MD 20910 USA. EM linton.yvonne3@gmail.com OI Foley, Desmond/0000-0001-7525-4601 FU WRAIR; Smithsonian Institution; National Research Council Senior Associateship Award FX WRAIR and the Smithsonian Institution, National Research Council Senior Associateship Award (to YML), fieldwork supported by University of South Carolina (to RCW) NR 60 TC 11 Z9 11 U1 2 U2 13 PU FUNDACO OSWALDO CRUZ PI RIO DE JANEIRO, RJ PA AV BRASIL 4365, 21045-900 RIO DE JANEIRO, RJ, BRAZIL SN 0074-0276 EI 1678-8060 J9 MEM I OSWALDO CRUZ JI Mem. Inst. Oswaldo Cruz PD DEC PY 2013 VL 108 SU 1 BP 100 EP U132 DI 10.1590/0074-0276130440 PG 29 WC Parasitology; Tropical Medicine SC Parasitology; Tropical Medicine GA 294ID UT WOS:000330037800014 PM 24473809 ER PT J AU Kwon, E Gallagher, LG Nielsen, SS Franklin, GM Littell, CT Longstreth, WT Swanson, PD Checkoway, H AF Kwon, Elena Gallagher, Lisa G. Nielsen, Susan Searles Franklin, Gary M. Littell, Christopher T. Longstreth, W. T., Jr. Swanson, Phillip D. Checkoway, Harvey TI Parkinson's disease and history of outdoor occupation SO PARKINSONISM & RELATED DISORDERS LA English DT Article DE Parkinson's disease; Occupation; Ultraviolet radiation; Vitamin D ID VITAMIN-D; RISK; SUNLIGHT AB Background: Human and animal studies, albeit not fully consistent, suggest that vitamin D may reduce risk of Parkinson's disease (PD). Ultraviolet radiation converts vitamin D precursor to the active form. This study examined the hypothesis that working outdoors is associated with a decreased risk of PD. Methods: PD cases were enrolled from Group Health Cooperative, a health maintenance organization in the Puget Sound region in western Washington State, and the University of Washington Neurology Clinic in Seattle. Participants included 447 non-Hispanic Caucasian newly diagnosed PD cases diagnosed between 1992 and 2008 and 578 unrelated neurologically normal controls enrolled in Group Health Cooperative, frequency matched by race/ethnicity, age and gender. Subjects' amount of outdoor work was estimated from self-reported occupational histories. Jobs were categorized by degree of time spent working outdoors. A ten-year lag interval was included to account for disease latency. Odds ratios (ORs) and 95% confidence intervals (Cls) were estimated by logistic regression, with adjustment for age, gender, and smoking. Results: Outdoor work was inversely associated with risk of PD (outdoor only compared to indoor only): OR = 0.74, 95% CI 0.44-1.25. However, there was no trend in relation to portion of the workday spent laboring outdoors and PD risk. Conclusion: Occupational sunlight exposure and other correlates of outdoor work is not likely to have a substantial role in the etiology of PD. (C) 2013 Elsevier Ltd. All rights reserved. C1 [Kwon, Elena; Littell, Christopher T.] US Army, Madigan Army Med Ctr, Dept Prevent Med, Adelphi, MD USA. [Gallagher, Lisa G.; Nielsen, Susan Searles; Franklin, Gary M.; Checkoway, Harvey] Univ Washington, Dept Environm & Occupat Hlth Sci, Seattle, WA 98195 USA. [Longstreth, W. T., Jr.; Swanson, Phillip D.] Univ Washington, Dept Neurol, Seattle, WA 98195 USA. [Longstreth, W. T., Jr.; Checkoway, Harvey] Univ Washington, Dept Epidemiol, Seattle, WA 98195 USA. RP Checkoway, H (reprint author), Univ Washington, Dept Environm & Occupat Hlth Sci, Box 357234, Seattle, WA 98195 USA. EM checko@u.washington.edu FU NIH, National Institute of Environmental Health Science [R01ES10750, P42ES004696] FX This study was supported by the NIH, National Institute of Environmental Health Science R01ES10750 and P42ES004696, the University of Washington Superfund Research Program. The authors are grateful to Group Health Cooperative and University of Washington neurologists for referral of PD cases and study interviewers for data collection. NR 10 TC 3 Z9 3 U1 1 U2 3 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1353-8020 EI 1873-5126 J9 PARKINSONISM RELAT D JI Parkinsonism Relat. Disord. PD DEC PY 2013 VL 19 IS 12 BP 1164 EP 1166 DI 10.1016/j.parkreldis.2013.08.014 PG 3 WC Clinical Neurology SC Neurosciences & Neurology GA 295AV UT WOS:000330089900019 PM 24044947 ER PT J AU Shaw, KA Balog, TP Grassbaugh, JA AF Shaw, K. Aaron Balog, Todd P. Grassbaugh, Jason A. TI The case: Diagnosis: Acrometastasis of the Thumb SO ORTHOPEDICS LA English DT Editorial Material ID METASTATIC TUMORS; HAND C1 [Shaw, K. Aaron] Dwight D Eisenhower Med Ctr, Dept Orthopaed Surg, Ft Gordon, GA 30915 USA. [Balog, Todd P.; Grassbaugh, Jason A.] Madigan Army Med Ctr, Orthoped Serv, Dept Surg, Ft Lewis, WA USA. RP Shaw, KA (reprint author), Dwight D Eisenhower Med Ctr, Dept Orthopaed Surg, 300 E Hosp Rd, Ft Gordon, GA 30915 USA. EM kenneth.a.shaw34.mil@mail.mil NR 14 TC 0 Z9 0 U1 0 U2 1 PU SLACK INC PI THOROFARE PA 6900 GROVE RD, THOROFARE, NJ 08086 USA SN 0147-7447 EI 1938-2367 J9 ORTHOPEDICS JI Orthopedics PD DEC PY 2013 VL 36 IS 12 BP 903 EP + DI 10.3928/01477447-20131120-01 PG 4 WC Orthopedics SC Orthopedics GA 290CK UT WOS:000329729900016 PM 24309117 ER PT J AU Wilton, JC Hardin, MO Ritchie, JD Chung, KK Aden, JK Cancio, LC Wolf, SE White, CE AF Wilton, Jonathan C. Hardin, Mark O. Ritchie, John D. Chung, Kevin K. Aden, James K. Cancio, Leopoldo C. Wolf, Steven E. White, Christopher E. TI Outcomes after cardiac arrest in an adult burn center SO BURNS LA English DT Article DE In-hospital cardiac arrest; Cardiopulmonary resuscitation; Burn patients; Thermal injury ID HOSPITAL CARDIOPULMONARY-RESUSCITATION; SURVIVAL; PREDICTORS; CHILDREN AB Objective: Adult burn patients who experience in-hospital cardiac arrest (CA) and undergo cardiopulmonary resuscitation (CPR) represent a unique patient population. We believe that they tend to be younger and have the added burden of the burn injury compared to other populations. Our objective was to determine the incidence, causes and outcomes following cardiac arrest (CA) and cardio-pulmonary resuscitation (CPR) within this population. Methods: We conducted a retrospective review at the US Army Institute of Surgical Research (ISR) burn intensive care unit (BICU). Charts from 1st January 2000 through 31st August 2009 were reviewed for study. Data were collected all on adult burn patients who experienced in-hospital CA and CPR either in the BICU or associated burn operating room. Patients undergoing CPR elsewhere in our bum unit were excluded because we could not validate the time of CA since they are not routinely monitored with real-time rhythm strips. The study population included civilian burn patients from the local catchment area and burn casualties from the conflicts in Iraq and Afghanistan, but patients with do-not-resuscitate (DNR) orders were excluded. Results: We found 57 burn patients who had in-hospital CA and CPR yielding an incidence of one or more in-hospital CA of 34 per 1000 admissions (0.34%). Fourteen of these patients (25%) survived to discharge while 43 (75%) died. The most common initial cardiac rhythm was pulseless electrical activity (50.9%). The most common etiology of CA among bum patients was respiratory failure (49.1%). The most significant variable affecting survival to discharge was duration of CPR (P < 0.01) with no patient surviving more than 7 min of CPR. Conclusions: CPR in bum patients is sometimes effective, and those patients who survive are likely to have good neurological outcomes. However, prolonged CPR times are unlikely to result in return of spontaneous circulation and may be considered futile. Further, those who experience multiple CA are unlikely to survive to discharge. Published by Elsevier Ltd and ISBI C1 [Wilton, Jonathan C.; Hardin, Mark O.; Ritchie, John D.; Chung, Kevin K.; Aden, James K.; Cancio, Leopoldo C.; Wolf, Steven E.; White, Christopher E.] US Army, Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP White, CE (reprint author), Brooke Army Med Ctr, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM christopher.eric.white@us.army.mil OI Wolf, Steven/0000-0003-2972-3440 NR 11 TC 2 Z9 3 U1 0 U2 3 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0305-4179 EI 1879-1409 J9 BURNS JI Burns PD DEC PY 2013 VL 39 IS 8 BP 1541 EP 1546 DI 10.1016/j.burns.2013.08.005 PG 6 WC Critical Care Medicine; Dermatology; Surgery SC General & Internal Medicine; Dermatology; Surgery GA 283RW UT WOS:000329265700005 PM 24011734 ER PT J AU Moser, RD Allison, PG Williams, BA Weiss, CA Diaz, AD Gore, ER Malone, PG AF Moser, R. D. Allison, P. G. Williams, B. A. Weiss, C. A., Jr. Diaz, A. D. Gore, E. R. Malone, P. G. TI Improvement in the geopolymer-to-steel bond using a reactive vitreous enamel coating SO CONSTRUCTION AND BUILDING MATERIALS LA English DT Article DE Geopolymer; Steel; Interface; SEM; EDX; Bond ID FLY-ASH; REINFORCING STEEL; CONCRETE; PORCELAIN; CEMENT AB This study examines the effectiveness of a reactive vitreous enamel coating on the surface of reinforcing steel on bond strengths and microstructural interactions with a geopolymer-based binder. Steel rods with and without the glassy enamel coating rich in Al, Si, and Ca were tested for bond strength when embedded in a Class F fly ash geopolymer. Microstructural characterization using scanning electron microscopy and energy-dispersive X-ray spectroscopy was also used to investigate the spatial distribution in microstructure and chemistry at the interface. The use of a reactive enamel coating on reinforcement was found to increase bond strengths by approximately 2.5 times based on push-out test specimens. The presence of the reactive enamel coating was found to decrease porosity at the interface and also provide a more gradual transition in microstructure and chemistry between the steel reinforcement and the geopolymeric matrix. Results of the study support investigation of the developed coating system for reinforcing bars, fibers, and stay-in-place formwork systems. Published by Elsevier Ltd. C1 [Moser, R. D.; Allison, P. G.; Williams, B. A.; Weiss, C. A., Jr.; Gore, E. R.; Malone, P. G.] US Army Engn Res & Dev Ctr, Geotech & Struct Lab, Vicksburg, MS 39180 USA. [Diaz, A. D.] Univ Puerto Rico, Dept Mech Engn, Mayaguez, PR 00680 USA. RP Moser, RD (reprint author), US Army Engn Res & Dev Ctr, Geotech & Struct Lab, Vicksburg, MS 39180 USA. EM Robert.D.Moser@usace.army.mil OI Allison, Paul/0000-0002-9041-237X FU U.S. Army Engineer Research and Development Center 6.1 Basic Research program FX The authors would like to acknowledge the funding provided for this work by the U.S. Army Engineer Research and Development Center 6.1 Basic Research program. This publication was approved by Director, Geotechnical and Structures Laboratory, U.S. Army Engineer Research and Development Center. NR 26 TC 6 Z9 6 U1 1 U2 21 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0950-0618 EI 1879-0526 J9 CONSTR BUILD MATER JI Constr. Build. Mater. PD DEC PY 2013 VL 49 BP 62 EP 69 DI 10.1016/j.conbuildmat.2013.08.001 PG 8 WC Construction & Building Technology; Engineering, Civil; Materials Science, Multidisciplinary SC Construction & Building Technology; Engineering; Materials Science GA 281DT UT WOS:000329080900009 ER PT J AU Sloan, SD Nolan, JJ Broadfoot, SW McKenna, JR Metheny, OM AF Sloan, Steven D. Nolan, Jeffery J. Broadfoot, Seth W. McKenna, Jason R. Metheny, Owen M. TI Using near-surface seismic refraction tomography and multichannel analysis of surface waves to detect shallow tunnels: A feasibility study SO JOURNAL OF APPLIED GEOPHYSICS LA English DT Article DE Near-surface; Seismic; Refraction; Surface wave; Void ID INVERSION AB Near-surface seismic refraction and surface wave data were collected at a site to determine the feasibility and limitations of using these seismic methods to detect and localize a shallow tunnel in unconsolidated sediments. Data sets were collected both before and after the construction of the tunnel. We were able to detect the air-filled cavity using multichannel analysis of surface waves. The refraction tomography results showed the tunnel location in the raypath coverage plots, but only small velocity variations were observed. In tandem the two methods would reduce false positives, but individually the false alarm rate would likely be high due to non-uniqueness of the results. In this geologic setting, these methods are not the best choice of geophysical methods to detect clandestine tunnels and should be combined with other geophysical techniques to improve and constrain interpretations. (C) 2013 Elsevier B.V. All rights reserved. C1 [Sloan, Steven D.; Broadfoot, Seth W.; Metheny, Owen M.] XRI Geophys LIC, Vicksburg, MS 39180 USA. [Nolan, Jeffery J.] Univ Kansas, Kansas Geol Survey, Lawrence, KS 66047 USA. [McKenna, Jason R.] US Army Engineer Res & Dev Ctr, Alexandria, VA 22315 USA. RP Sloan, SD (reprint author), XRI Geophys LIC, 6207 Highway 80, Vicksburg, MS 39180 USA. EM Steve.Sloan@xrigeo.com; nolanjj2@gmail.com; seth.broadfoot@xrigeo.com; Jason.McKenna@gmail.com; owen.metheny@xrigeo.com NR 22 TC 2 Z9 2 U1 5 U2 20 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0926-9851 EI 1879-1859 J9 J APPL GEOPHYS JI J. Appl. Geophys. PD DEC PY 2013 VL 99 SI SI BP 60 EP 65 DI 10.1016/j.jappgeo.2013.10.004 PG 6 WC Geosciences, Multidisciplinary; Mining & Mineral Processing SC Geology; Mining & Mineral Processing GA 283VP UT WOS:000329275400008 ER PT J AU Ghionea, S Hull, D Williams, K AF Ghionea, Simon Hull, David Williams, Kirt TI Characterization techniques for a MEMS electric-field sensor in vacuum SO JOURNAL OF ELECTROSTATICS LA English DT Article DE Electric field sensor; MEMS; Vacuum insitu characterization AB An accurate calibration of an electric-field sensor is difficult to carry out due to challenges involved in generating a uniform electric field over the sensor volume. Additionally, capacitive coupling between the field source and the sensors and related instrumentation tends to distort the measured field further. Sensor characterization includes not only calibration, but also determination of the frequency response (both magnitude and phase), noise power spectral density, dynamic range, and linearity. In this paper, we discuss characterization techniques for an unpackaged microelectromechanical systems (MEMS) electric field sensor in a vacuum chamber. The use of oppositely charged square plates at a spacing of half the plate width is advised by the IEEE 1308-1994 standard for generation of a uniform electric field. Previously, the U.S. Army Research Laboratory (ARL) has shown that by employing guard tubes in the construction of an electric field generating chamber, the fringing fields can be controlled, and the spacing between the endplates can be increased while maintaining a uniform field. A similar, smaller apparatus for generating a uniform axial electric field was constructed to fit into a vacuum bell jar. The considerations and techniques for minimizing error due to fringing and distortion from metal conductors will be presented, along with the techniques and laboratory equipment used for characterizing the sensor. Published by Elsevier B.V. C1 [Ghionea, Simon; Hull, David] US Army, Sensors & Electron Devices Directorate, Res Lab, Adelphi, MD 20723 USA. [Williams, Kirt] Sci Applicat Int Corp, Sensor Technol Div, Mclean, VA 22102 USA. RP Ghionea, S (reprint author), US Army, Sensors & Electron Devices Directorate, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20723 USA. EM simon.j.ghionea.civ@mail.mil; david.m.hull6.civ@mail.mil; kirt.r.williams@saic.com NR 17 TC 2 Z9 2 U1 4 U2 10 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0304-3886 EI 1873-5738 J9 J ELECTROSTAT JI J. Electrost. PD DEC PY 2013 VL 71 IS 6 BP 1076 EP 1082 DI 10.1016/j.elstat.2013.09.002 PG 7 WC Engineering, Electrical & Electronic SC Engineering GA 285UF UT WOS:000329419800019 ER PT J AU Moosman, PR Veilleux, JP Pelton, GW Thomas, HH AF Moosman, Paul R., Jr. Veilleux, Jacques P. Pelton, Gary W. Thomas, Howard H. TI Changes in Capture Rates in a Community of Bats in New Hampshire during the Progression of White-nose Syndrome SO NORTHEASTERN NATURALIST LA English DT Article ID SUMMER; MORTALITY; DISEASE; IMPACT AB Effects of white-nose syndrome (WNS) have mainly been assessed in bats at hibernacula, but this method may not be appropriate for species with poorly understood overwintering habits. We assessed effects of WNS on summer captures of Myotis leibii (Eastern Small-footed Bat), M. lucifugus (Little Brown Bat), M. septentrionalis (Northern Long-eared Bat), and Eptesicus fuscus (Big Brown Bat) in New Hampshire from 2005-2011. Declines in rates and probability of capture varied among species but were greatest in the Myotis. Trends generally agreed with previous studies, except that declines in captures of Eastern Small-footed Bats were disproportionately higher than expected from winter estimates. Monitoring of Eastern Small-footed Bats during the non-hibernation period likely will help to clarify the effects of WNS on this uncommon species. C1 [Moosman, Paul R., Jr.] Virginia Mil Inst, Lexington, VA 24450 USA. [Veilleux, Jacques P.] Franklin Pierce Univ, Rindge, NH 03461 USA. [Pelton, Gary W.] US Army Corps Engineers, Perkinsville, VT 05151 USA. [Thomas, Howard H.] Fitchburg State Univ, Fitchburg, MA 01420 USA. RP Moosman, PR (reprint author), Virginia Mil Inst, Lexington, VA 24450 USA. EM moosmanpr@vmi.edu NR 18 TC 6 Z9 8 U1 4 U2 49 PU HUMBOLDT FIELD RESEARCH INST PI STEUBEN PA PO BOX 9, STEUBEN, ME 04680-0009 USA SN 1092-6194 EI 1938-5307 J9 NORTHEAST NAT JI Northeast. Nat PD DEC PY 2013 VL 20 IS 4 BP 552 EP 558 DI 10.1656/045.020.0405 PG 7 WC Biodiversity Conservation; Ecology SC Biodiversity & Conservation; Environmental Sciences & Ecology GA 283EB UT WOS:000329227100007 ER PT J AU Beaumier, CM Gomez-Rubio, AM Hotez, PJ Weina, PJ AF Beaumier, Coreen M. Gomez-Rubio, Ana Maria Hotez, Peter J. Weina, Peter J. TI United States Military Tropical Medicine: Extraordinary Legacy, Uncertain Future SO PLOS NEGLECTED TROPICAL DISEASES LA English DT Editorial Material ID WORLD-WAR-II; INFECTIOUS-DISEASES; US MILITARY; PERSIAN-GULF; LEISHMANIASIS; OPERATIONS; OUTBREAK; VIETNAM; MALARIA; HEALTH C1 [Beaumier, Coreen M.; Gomez-Rubio, Ana Maria; Hotez, Peter J.] Baylor Coll Med, Dept Pediat, Natl Sch Trop Med, Houston, TX 77030 USA. [Beaumier, Coreen M.; Gomez-Rubio, Ana Maria; Hotez, Peter J.] Baylor Coll Med, Dept Mol Virol & Microbiol, Natl Sch Trop Med, Houston, TX 77030 USA. [Beaumier, Coreen M.; Gomez-Rubio, Ana Maria; Hotez, Peter J.] Sabin Vaccine Inst, Houston, TX USA. [Beaumier, Coreen M.; Gomez-Rubio, Ana Maria; Hotez, Peter J.] Texas Childrens Hosp, Ctr Vaccine Dev, Houston, TX 77030 USA. [Hotez, Peter J.] Rice Univ, James A Baker III Inst Publ Policy, Houston, TX USA. [Weina, Peter J.] Walter Reed Army Inst Res, Silver Spring, MD USA. RP Beaumier, CM (reprint author), Baylor Coll Med, Dept Pediat, Natl Sch Trop Med, Houston, TX 77030 USA. EM beaumier@bcm.edu; hotez@bcm.edu; peter.weina@us.army.mil RI Weina, Peter/A-2120-2011; OI Hotez, Peter/0000-0001-8770-1042 NR 25 TC 1 Z9 1 U1 1 U2 2 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1935-2735 J9 PLOS NEGLECT TROP D JI Plos Neglect. Trop. Dis. PD DEC PY 2013 VL 7 IS 12 AR e2448 DI 10.1371/journal.pntd.0002448 PG 6 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA 282JU UT WOS:000329168100003 PM 24386494 ER PT J AU Rabaa, MA Simmons, CP Fox, A Le, MQ Nguyen, TTT Le, HY Gibbons, RV Nguyen, XT Holmes, EC Aaskov, JG AF Rabaa, Maia A. Simmons, Cameron P. Fox, Annette Mai Quynh Le Thuy Thi Thu Nguyen Hai Yen Le Gibbons, Robert V. Xuyen Thanh Nguyen Holmes, Edward C. Aaskov, John G. TI Dengue Virus in Sub-tropical Northern and Central Viet Nam: Population Immunity and Climate Shape Patterns of Viral Invasion and Maintenance SO PLOS NEGLECTED TROPICAL DISEASES LA English DT Article ID AEDES-AEGYPTI; MOLECULAR CHARACTERIZATION; PHYLOGENETIC UNCERTAINTY; GUANGDONG PROVINCE; SOUTHERN VIETNAM; KAMPHAENG-PHET; CHINA; OUTBREAK; THAILAND; FEVER AB Dengue virus transmission occurs in both epidemic and endemic cycles across tropical and sub-tropical regions of the world. Incidence is particularly high in much of Southeast Asia, where hyperendemic transmission plagues both urban and rural populations. However, endemicity has not been established in some areas with climates that may not support year-round viral transmission. An understanding of how dengue viruses (DENV) enter these environments and whether the viruses persist in inapparent local transmission cycles is central to understanding how dengue emerges in areas at the margins of endemic transmission. Dengue is highly endemic in tropical southern Vietnam, while increasingly large seasonal epidemics have occurred in northern Viet Nam over the last decade. We have investigated the spread of DENV-1 throughout Vietnam to determine the routes by which the virus enters northern and central regions of the country. Phylogeographic analysis of 1,765 envelope (E) gene sequences from Southeast Asia revealed frequent movement of DENV between neighboring human populations and strong local clustering of viral lineages. Long-distance migration of DENV between human population centers also occurred regularly and on short time-scales, indicating human-mediated viral invasion into northern Vietnam. Human populations in southern Vietnam were found to be the primary source of DENV circulating throughout the country, while central and northern Vietnam acted as sink populations, likely due to reduced connectedness to other populations in the case of the central regions and to the influence of temperature variability on DENV replication and vector survival and competence in the north. Finally, phylogeographic analyses suggested that viral movement follows a gravity model and indicates that population immunity and physical and economic connections between populations may play important roles in shaping patterns of DENV transmission. Author Summary Reports from sub-tropical regions of the world suggest a growing risk of introduction and establishment of dengue viruses (DENV) in new locales. Recent dengue epidemics in northern Viet Nam present an opportunity to study how DENV invades and spreads in these environments. The proximity of this region to tropical areas experiencing year-round endemic DENV transmission makes it an ideal site for studying the effects of human population movement and climate on DENV emergence. We performed a phylogenetic analysis using DENV-1 envelope gene sequences from Southeast Asia. We show that DENV are regularly imported into northern and central Viet Nam from southern Vietnam, and that increasingly large seasonal epidemics in the north are caused by newly introduced viruses each year. While tropical Vietnam maintains localized virus populations for multiple years, cool winter temperatures in sub-tropical northern Viet Nam may reduce mosquito populations and virus replication to levels that are not conducive to year-round DENV transmission. Finally, we found that the dispersal of DENV across the region is well-described using human movement and immunity data, and believe that increased epidemiological, entomological, and virological surveillance are needed to understand the processes by which endemic DENV transmission becomes established in new populations. C1 [Rabaa, Maia A.] Univ Edinburgh, Ctr Immun Infect & Evolut, Edinburgh, Midlothian, Scotland. [Rabaa, Maia A.; Simmons, Cameron P.] Univ Oxford, Clin Res Unit, Hosp Trop Dis, Ho Chi Minh City, Vietnam. [Simmons, Cameron P.; Fox, Annette] Univ Oxford, Nuffield Dept Clin Med, Ctr Trop Med, Oxford, England. [Fox, Annette] Univ Oxford, Clin Res Unit, Wellcome Trust Major Overseas Programme, Hanoi, Vietnam. [Mai Quynh Le; Thuy Thi Thu Nguyen] Natl Inst Hyg & Epidemiol, Hanoi, Vietnam. [Hai Yen Le; Xuyen Thanh Nguyen] Mil Inst Hyg & Epidemiol, Hanoi, Vietnam. [Gibbons, Robert V.] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Holmes, Edward C.] Univ Sydney, Sch Biol Sci, Marie Bashir Inst Emerging Dis & Biosecur, Sydney, NSW 2006, Australia. [Holmes, Edward C.] Univ Sydney, Sydney Med Sch, Sydney, NSW 2006, Australia. [Holmes, Edward C.] NIH, Fogarty Int Ctr, Bethesda, MD 20892 USA. [Aaskov, John G.] Queensland Univ Technol, Brisbane, Qld 4001, Australia. [Aaskov, John G.] Australian Army Malaria Inst, Brisbane, Qld, Australia. RP Rabaa, MA (reprint author), Univ Edinburgh, Ctr Immun Infect & Evolut, Edinburgh, Midlothian, Scotland. EM j.aaskov@qut.edu.au OI Rabaa, Maia/0000-0003-0529-2228; Simmons, Cameron P./0000-0002-9039-7392; Holmes, Edward/0000-0001-9596-3552 FU National Science Foundation Graduate Research Fellowship; Wellcome Trust of the United Kingdom through the Vietnamese Initiative on Zoonotic InfectiONS (WT-VIZIONS); National Health and Medical Research Council of Australia; U.S. Global Emerging Infections Surveillance and Response System; National Institutes of Health [R01 GM087405] FX Funding to MAR was provided by a National Science Foundation Graduate Research Fellowship and by the Wellcome Trust of the United Kingdom through the Vietnamese Initiative on Zoonotic InfectiONS (WT-VIZIONS). This study was supported by grants from the National Health and Medical Research Council of Australia (including an Australia Fellowship to ECH), the U.S. Global Emerging Infections Surveillance and Response System, and the National Institutes of Health (grant R01 GM087405 to ECH). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 60 TC 10 Z9 10 U1 0 U2 18 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1935-2735 J9 PLOS NEGLECT TROP D JI Plos Neglect. Trop. Dis. PD DEC PY 2013 VL 7 IS 12 AR e2581 DI 10.1371/journal.pntd.0002581 PG 12 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA 282JU UT WOS:000329168100016 PM 24340118 ER PT J AU Hoover, JJ George, SG Killgore, KJ AF Hoover, Jan Jeffrey George, Steven G. Killgore, K. Jack TI A Paddlefish Entrained by the 2011 Mississippi River Flood: Rescue, Recapture, and Inferred Swim Speed SO SOUTHEASTERN NATURALIST LA English DT Article ID POLYODON-SPATHULA; MISSOURI RIVER AB We observed a large adult Paddlefish entrained from the Mississippi River through the Bonnet Cane spillway, south Louisiana, which was injured and underweight. We captured, measured (23 metrics), and tagged the fish. After it had spent a week at large on the fioodway, we recaptured and released it back into the Mississippi River. The specimen was re-captured eight months later in northern Mississippi, 627 km upriver from where it was released. Distance traveled and water velocities in the river indicate that the fish was traveling at least 90-197 cm/s for prolonged periods, equivalent to gross speeds of 77-170 km/d. This incident suggests that a large entrained fish, trapped for several days in a hyperthermic and hypoxic habitat, can be viable when returned to the river. It also demonstrated that rescue efforts could reduce impacts of spillway operations to fish populations, and that comprehensive field assessment of fish morphology can be benign to fish. C1 [Hoover, Jan Jeffrey; George, Steven G.; Killgore, K. Jack] US Army Engineer Res & Dev Ctr, EE A, Vicksburg, MS 39180 USA. RP Hoover, JJ (reprint author), US Army Engineer Res & Dev Ctr, EE A, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM Jan.J.Hoover@usace.army.mil FU US Army Engineer New Orleans District, New Orleans, LA; Basic Military Engineering Research Program FX Funding for field studies at Bonnet Can was provided by the US Army Engineer New Orleans District, New Orleans, LA. Funding for our Paddlefish morphology study is provided by the Basic Military Engineering Research Program. Field collections were conducted by the ERDC Fish Ecology Team and Louisiana Department of Wildlife and Fisheries, Lacombe Office. Assistance with logistics and data-recording were provided by Chris Brantley, Bill Maus, Alan Katzenmeyer, and Todd Slack. Re-capture was reported by William Lancaster. Permission to publish was granted by the Chief of Engineers, Army Corps of Engineers. NR 24 TC 0 Z9 0 U1 1 U2 4 PU HUMBOLDT FIELD RESEARCH INST PI STEUBEN PA PO BOX 9, STEUBEN, ME 04680-0009 USA SN 1528-7092 J9 SOUTHEAST NAT JI Southeast. Nat. PD DEC PY 2013 VL 12 IS 4 BP N26 EP N30 DI 10.1656/058.012.0418 PG 5 WC Biodiversity Conservation; Ecology SC Biodiversity & Conservation; Environmental Sciences & Ecology GA 283EN UT WOS:000329228600004 ER PT J AU Proie, RM Polcawich, RG Cress, CD Sanchez, LM Grobicki, AD Pulskamp, JS Roche, NJH AF Proie, Robert M., Jr. Polcawich, Ronald G. Cress, Cory D. Sanchez, Luz M. Grobicki, Alden D. Pulskamp, Jeffrey S. Roche, Nicolas J-H. TI Total Ionizing Dose Effects in Piezoelectric MEMS Relays SO IEEE TRANSACTIONS ON NUCLEAR SCIENCE LA English DT Article; Proceedings Paper CT 50th annual IEEE Nuclear and Space Radiation Effects Conference (NSREC) CY JUL 08-12, 2013 CL San Francisco, CA DE Digital circuits; low-power electronics; microelectromechanical systems; piezoelectric actuators; radiation effects; radiation hardending (electronics) ID LEAD-ZIRCONATE-TITANATE; THIN-FILMS; RADIATION AB This paper investigates total ionizing dose (TID) effects on the piezoelectric properties of lead zirconate titanate (PZT). The capacitance and contact voltage of thin-film, PZT-based relays were measured following incremental Co-60 TID irradiations. The devices were held in several different bias conditions, during exposure. The direction of the biasing electric field during exposure, along with the polarization prior to exposure, has a measurable impact on post-irradiation operating voltage of the relay. In all cases, the switching voltage, as obtained via the peak values in a capacitance versus voltage sweep, shifted in a direction that would minimize the switching electric field in the direction of pre-exposure polarization. These effects were observed to be both significantly greater than the shifts experienced by a set of control samples, as well as reversible via aging at room temperature. The devices display remarkable robustness, operating during active TID exposure [dose rate = 855.6 rad(Si)/s], failing at a TID greater than 15 Mrad(Si). C1 [Proie, Robert M., Jr.; Polcawich, Ronald G.; Sanchez, Luz M.; Grobicki, Alden D.; Pulskamp, Jeffrey S.] US Army Res Lab, Adelphi, MD 20783 USA. [Cress, Cory D.; Roche, Nicolas J-H.] US Naval Res Lab, Washington, DC 20375 USA. [Roche, Nicolas J-H.] George Washington Univ, Washington, DC 20052 USA. RP Proie, RM (reprint author), US Army Res Lab, Adelphi, MD 20783 USA. EM robert.m.proie.civ@mail.mil; ronald.g.polcawich.civ@mail.mil; cory.cress@nrl.navy.mil; luz.m.sanchez16.civ@mail.mil; alden.d.grobicki.civ@mail.mil; jeffrey.s.pul-skamp.civ@mail.mil; nroche@gwu.edu OI Cress, Cory/0000-0001-7563-6693 FU U.S. Army Research Laboratory; U.S. Naval Research Laboratory FX This work was supported in part by the U.S. Army Research Laboratory and the U.S. Naval Research Laboratory. NR 19 TC 3 Z9 3 U1 1 U2 13 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0018-9499 EI 1558-1578 J9 IEEE T NUCL SCI JI IEEE Trans. Nucl. Sci. PD DEC PY 2013 VL 60 IS 6 BP 4505 EP 4511 DI 10.1109/TNS.2013.2282261 PN 1 PG 7 WC Engineering, Electrical & Electronic; Nuclear Science & Technology SC Engineering; Nuclear Science & Technology GA 279NY UT WOS:000328967900065 ER PT J AU Sacks, D Kim, E Russell, P AF Sacks, Daniel Kim, Esther Russell, Paul TI The Role of the Endonasal Endoscope in the Operative Management of Brain Abscess: A Case Report SO JOURNAL OF NEUROLOGICAL SURGERY PART A-CENTRAL EUROPEAN NEUROSURGERY LA English DT Article DE transnasal approach; minimally invasive; endoscopy; skull base AB BackgroundThe endonasal endoscope has become widely integrated into the operative practice of skull-base surgeons. Although it is not the current standard of practice for the drainage of intracranial abscesses, transnasal neuroendoscopy has the potential for benefit over both stereotaxy and open craniotomy because it is minimally invasive and provides a visual confirmation of debridement. We present two recent cases in which patients with intradural abscesses adjacent to the anterior skull base were successfully drained and irrigated using an endoscopic approach. CaseTwo patients with post-traumatic intradural brain abscess underwent transnasal neuroendoscopic drainage in a 1-year period. In both cases, the abscesses were drained and irrigated without complication under direct visualization. The patients' outcomes were felt to be positive given their initial insults. ConclusionTransnasal endoscopic drainage of brain abscesses appears to be safe and has particular advantages in specific cases over the current operative standard, which are likely to prove beneficial for patients and cement it as a feasible alternative to stereotactic aspiration and craniotomy. C1 [Sacks, Daniel] Vanderbilt Univ, Sch Med, Nashville, TN 37212 USA. [Kim, Esther] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [Russell, Paul] Vanderbilt Univ, Nashville, TN 37212 USA. RP Sacks, D (reprint author), Vanderbilt Univ, Sch Med, Nashville, TN 37212 USA. EM daniel.n.sacks@gmail.com NR 11 TC 0 Z9 0 U1 0 U2 0 PU THIEME MEDICAL PUBL INC PI NEW YORK PA 333 SEVENTH AVE, NEW YORK, NY 10001 USA SN 2193-6315 EI 2193-6323 J9 J NEUROL SURG PART A JI J. Neurol. Surg. Part A PD DEC PY 2013 VL 74 SU 1 BP E54 EP E57 DI 10.1055/s-0032-1330955 PG 4 WC Clinical Neurology; Surgery SC Neurosciences & Neurology; Surgery GA 274CH UT WOS:000328582200012 PM 23315668 ER PT J AU Dixon, B Gilda, L Mangieri, T AF Dixon, Boyd Gilda, Laura Mangieri, Tina TI Archaeological Identification of Stone Fish-weirs Mentioned to Freycinet in 1819 on the Island of Guam SO JOURNAL OF PACIFIC HISTORY LA English DT Article ID MARIANA-ISLANDS; PACIFIC AB In 1819, when the French corvette L'Uranie anchored off Apra Harbor in the Micronesian Island of Guam, its captain Louis Claude de Freycinet was told of the former use there of stone fish-weirs. This reference has long puzzled archaeologists and historians who assumed Freycinet was misinformed or such features were no longer in existence, given the frequent typhoons that affect the region. Recent archaeological surveys of Apra Harbor tidal flats, however, have identified low-walled coral enclosures at the mouth of two freshwater estuaries. At first. these were hypothesised to have been built to foster shellfish production under the Japanese occupation of Guam during World War II. However, controlled excavation of small sites adjacent to one of these complexes yielded late Latte Period pottery and wood charcoal radiocarbon dated to AD 1645-1725. This historic timeframe is within the plausible memory of the oldest generation of Freycinet's informants. These archaeological findings, combined with interviews, research of historical accounts and ethnographic comparisons of fishing practices in Micronesia and further afield suggest that Chamorro fishermen may have used the weirs to feed local populations and visiting sailors during the seasonal arrival of the Manila galleons for a long period after Ferdinand Magellan's visit in 1521. This conclusion has practical and contemporary implications for Chamorro today. C1 [Dixon, Boyd] Cardno TEC, Tamuning, Guam 96913, US. [Gilda, Laura] US Army Garrison Hawaii, DPW Environm Conservat & Restorat Branch, Schofield, HI 96888 USA. [Mangieri, Tina] SIT Study Abroad, Brattleboro, VT 05302 USA. RP Dixon, B (reprint author), Cardno TEC, 425 Chalan San Antonio Rd,PMB 1004, Tamuning, Guam 96913, US. EM dixonboyd@hotmail.com; laura.l.gilda.civ@mail.mil; tina.mangieri@sit.edu NR 61 TC 0 Z9 0 U1 0 U2 0 PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND SN 0022-3344 EI 1469-9605 J9 J PAC HIST JI J. Pac. Hist. PD DEC 1 PY 2013 VL 48 IS 4 BP 349 EP 368 DI 10.1080/00223344.2013.856666 PG 20 WC History SC History GA 273KN UT WOS:000328533800001 ER PT J AU Scully, WF Wilson, DJ Parada, SA Arrington, ED AF Scully, William F. Wilson, David J. Parada, Stephen A. Arrington, Edward D. TI Iatrogenic Nerve Injuries in Shoulder Surgery SO JOURNAL OF THE AMERICAN ACADEMY OF ORTHOPAEDIC SURGEONS LA English DT Review ID SPINAL ACCESSORY NERVE; ROTATOR-CUFF TEARS; AXILLARY NERVE; SUPRASCAPULAR NERVE; LATARJET PROCEDURE; MUSCULOCUTANEOUS NERVE; ARTHROPLASTY; REPAIR; REPLACEMENT; ANATOMY AB The range of open and arthroscopic shoulder procedures continues to evolve and expand. Despite advances in instrumentation and technology, complications still exist and neurologic injury remains an inherent part of these procedures. latrogenic nerve injuries are among the more commonly cited complications associated with shoulder surgery. Various surgical procedures about the shoulder are known to place the brachial plexus and peripheral motor nerves at risk. Peripheral nerve monitoring has been helpful in identifying specific surgical steps and key anatomic regions that are susceptible to iatrogenic nerve injury. C1 [Scully, William F.; Wilson, David J.; Arrington, Edward D.] Madigan Army Med Ctr, Dept Surg, Orthoped Surg Serv, Tacoma, WA 98431 USA. [Parada, Stephen A.] Womack Army Med Ctr, Dept Orthoped & Rehabil, Ft Bragg, NC USA. RP Scully, WF (reprint author), Madigan Army Med Ctr, Dept Surg, Orthoped Surg Serv, Tacoma, WA 98431 USA. NR 45 TC 6 Z9 7 U1 0 U2 2 PU AMER ACAD ORTHOPAEDIC SURGEONS PI ROSEMENT PA 6300 N RIVER ROAD, ROSEMENT, IL 60018-4262 USA SN 1067-151X J9 J AM ACAD ORTHOP SUR JI J. Am. Acad. Orthop. Surg. PD DEC PY 2013 VL 21 IS 12 BP 717 EP 726 DI 10.5435/JAAOS-21-12-717 PG 10 WC Orthopedics; Surgery SC Orthopedics; Surgery GA 280EO UT WOS:000329011700002 PM 24292928 ER PT J AU Sutorik, AC Cooper, C Gilde, G AF Sutorik, Anthony C. Cooper, Christopher Gilde, Gary TI Visible Light Transparency for Polycrystalline Ceramics of MgO center dot 2Al(2)O(3) and MgO center dot 2.5Al(2)O(3) Spinel Solid Solutions SO JOURNAL OF THE AMERICAN CERAMIC SOCIETY LA English DT Article ID MAGNESIUM ALUMINATE SPINEL; MGO.2AL2O3 SPINEL; HISTORY AB Magnesium aluminate spinel solid solutions with the alumina-rich compositions MgO2Al(2)O(3) and MgO2.5Al(2)O(3) have been prepared as polycrystalline ceramics with average in-line transmissions at 550nm of 85.5 +/- 0.3% and 80.9 +/- 0.4%, respectively. Starting powders are prepared from combinations of high purity Mg(OH)(2) and -Al2O3 thoroughly mixed in an aqueous slurry, and the solids are collected, dried, calcined, mixed with LiF sintering aid, and sieved. The optimum amount of LiF added varies with the alumina composition of the spinel solid solution. The powders are sintered into dense ceramics by hot pressing at 1600 degrees C under vacuum and 20MPa uniaxial load followed by hot isostatic pressing at 1850 degrees C under 200MPa in Ar. Both compositions exhibit exaggerated grain growth with average sizes well over 500m. Knoop hardness measurements are 11.2 +/- 0.3GPa for MgO2Al(2)O(3) and 11.0 +/- 0.4GPa for MgO2.5Al(2)O(3). C1 [Sutorik, Anthony C.; Cooper, Christopher; Gilde, Gary] US Army Res Lab, Attn RDRL WMM E, Aberdeen, MD 21005 USA. RP Sutorik, AC (reprint author), Dow Corning Corp, Midland, MI USA. EM anthony.sutorik@dowcorning.com NR 24 TC 2 Z9 2 U1 3 U2 11 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0002-7820 EI 1551-2916 J9 J AM CERAM SOC JI J. Am. Ceram. Soc. PD DEC PY 2013 VL 96 IS 12 BP 3704 EP 3707 DI 10.1111/jace.12636 PG 4 WC Materials Science, Ceramics SC Materials Science GA 267MN UT WOS:000328102100004 ER PT J AU Butini, S Brindisi, M Brogi, S Maramai, S Guarino, E Panico, A Saxena, A Chauhan, V Colombo, R Verga, L De Lorenzi, E Bartolini, M Andrisano, V Novellino, E Campiani, G Gemma, S AF Butini, Stefania Brindisi, Margherita Brogi, Simone Maramai, Samuele Guarino, Egeria Panico, Alessandro Saxena, Ashima Chauhan, Ved Colombo, Raffaella Verga, Laura De Lorenzi, Ersilia Bartolini, Manuela Andrisano, Vincenza Novellino, Ettore Campiani, Giuseppe Gemma, Sandra TI Multifunctional Cholinesterase and Amyloid Beta Fibrillization Modulators. Synthesis and Biological Investigation SO ACS MEDICINAL CHEMISTRY LETTERS LA English DT Article DE Cholinesterase inhibitors; amyloid beta-peptides; multifunctional tools; amyloid beta oligomers; Alzheimer's disease; bivalent ligands ID ALZHEIMERS-DISEASE; DESIGN STRATEGY; DRUG DESIGN; ACETYLCHOLINESTERASE; AGGREGATION; TARGET; SITE; INHIBITORS; PEPTIDE; PROTEIN AB In order to identify novel Alzheimer's modifying pharmacological tools, we developed bis-tacrines bearing a peptide moiety for specific interference with surface sites of human acetylcholinesterase (hAChE) binding amyloid-beta (A beta). Accordingly, compounds 2a-c proved to be inhibitors of hAChE catalytic and noncatalytic functions, binding the catalytic and peripheral sites, interfering with A beta aggregation and with the A beta self-oligomerization process (2a). Compounds 2a-c in complex with TcAChE span the gorge with the bis-tacrine system, and the peptide moieties bulge outside the gorge in proximity of the peripheral site These moieties are likely responsible for the observed reduction of hAChE-induced A beta aggregation since they physically hamper A beta binding to the enzyme surface. Moreover, 2a was able to significantly interfere with A beta self-oligornerization, while 2b,c showed improved inhibition of hAChE-induced A beta aggregation. C1 [Butini, Stefania; Brindisi, Margherita; Brogi, Simone; Maramai, Samuele; Guarino, Egeria; Panico, Alessandro; Novellino, Ettore; Campiani, Giuseppe; Gemma, Sandra] Univ Siena, European Res Ctr Drug Discovery & Dev NatSynDrugs, I-53100 Siena, Italy. [Butini, Stefania; Brindisi, Margherita; Brogi, Simone; Maramai, Samuele; Guarino, Egeria; Panico, Alessandro; Campiani, Giuseppe; Gemma, Sandra] Univ Siena, Dipartimento Biotecnol Chim & Farm, I-53100 Siena, Italy. [Saxena, Ashima] Walter Reed Army Inst Res, Div Biochem, Silver Spring, MD 20910 USA. [Chauhan, Ved] New York State Inst Basic Res Dev Disabil, Staten Isl, NY 10314 USA. [Colombo, Raffaella; De Lorenzi, Ersilia] Univ Pavia, Dipartimento Sci Farm, I-27100 Pavia, Italy. [Verga, Laura] Policlin San Matteo, Fdn IRCCS, Dept Pathol, I-27100 Pavia, Italy. [Verga, Laura] Univ Pavia, I-27100 Pavia, Italy. [Bartolini, Manuela] Univ Bologna, Dept Pharm & Biotechnolgy, I-40126 Bologna, Italy. [Andrisano, Vincenza] Univ Bologna, Dept Life Qual Studies, I-47900 Rimini, Italy. [Novellino, Ettore] Univ Naples Federico II, Dipartimento Farm, I-80131 Naples, Italy. RP Campiani, G (reprint author), Univ Siena, European Res Ctr Drug Discovery & Dev NatSynDrugs, Via Aldo Moro 2, I-53100 Siena, Italy. EM campiani@unisi.it RI Gemma, Sandra/D-3568-2009; butini, stefania/D-9954-2015; OI Gemma, Sandra/0000-0002-8313-2417; Colombo, Raffaella/0000-0001-9675-6598; brogi, simone/0000-0001-9375-6242; ANDRISANO, VINCENZA/0000-0003-4396-1904; Bartolini, Manuela/0000-0002-2890-3856; De Lorenzi, Ersilia/0000-0002-5450-7208 FU NatSynDrugs; Italian Ministry of University and Research [PRIN 2009Z8YTYC, 2010M2JARJ_008]; Prog. Reg. Lombardia [SAL-45 ID17261]; Unirimini S.p.A. FX We acknowledge NatSynDrugs, the Italian Ministry of University and Research (Project PRIN 2009Z8YTYC, and 2010M2JARJ_008), Prog. Reg. Lombardia SAL-45 ID17261, and Unirimini S.p.A. for financial support. NR 24 TC 8 Z9 8 U1 1 U2 11 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1948-5875 J9 ACS MED CHEM LETT JI ACS Med. Chem. Lett. PD DEC PY 2013 VL 4 IS 12 BP 1178 EP 1182 DI 10.1021/ml4002908 PG 5 WC Chemistry, Medicinal SC Pharmacology & Pharmacy GA 273IV UT WOS:000328529400014 PM 24900626 ER PT J AU Leon, LR Dineen, S Blaha, MD Rodriguez-Fernandez, M Clarke, DC AF Leon, Lisa R. Dineen, Shauna Blaha, Michael D. Rodriguez-Fernandez, Maria Clarke, David C. TI Attenuated thermoregulatory, metabolic, and liver acute phase protein response to heat stroke in TNF receptor knockout mice SO AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY LA English DT Article DE TNF; IL-6; heat stress; hyperthermia; acute phase response ID TUMOR-NECROSIS-FACTOR; FACTOR-ALPHA-CACHECTIN; HEATSTROKE; STRESS; CYTOKINES; MOUSE; INDUCTION; INFLAMMATION; TEMPERATURE; TISSUE AB Tumor necrosis factor (TNF) is considered an adverse mediator of heat stroke (HS) based on clinical studies showing high serum levels. However, soluble TNF receptors (sTNFR; TNF antagonists) were higher in survivors than nonsurvivors, and TNFR knockout (KO) mice showed a trend toward increased mortality, suggesting TNF has protective actions for recovery. We delineated TNF actions in HS by comparing thermoregulatory, metabolic, and inflammatory responses between B6129F(2) (wild type, WT) and TNFR KO mice. Before heat exposure, TNFR KO mice showed similar to 0.4 degrees C lower core temperature (T-c; radiotelemetry), similar to 10% lower metabolic rate (M-r; indirect calorimetry), and reduced plasma interleukin (IL)-1 alpha and sIL-1RI than WT mice. KO mice selected warmer temperatures than WT mice in a gradient but remained hypothermic. In the calorimeter, both genotypes showed a similar heating rate, but TNFR KO maintained lower T-c and Mr than WT mice for a given heat exposure duration and required similar to 30 min longer to reach maximum T-c (42.4 degrees C). Plasma IL-6 increased at similar to 3 h of recovery in both genotypes, but KO mice showed a more robust sIL-6R response. Higher sIL-6R in the KO mice was associated with delayed liver p-STAT3 protein expression and attenuated serum amyloid A3 (SAA3) gene expression, suggesting the acute phase response (APR) was attenuated in these mice. Our data suggest that the absence of TNF signaling induced a regulated hypothermic state in the KO mice, TNF-IL-1 interactions may modulate T-c and Mr during homeostatic conditions, and TNF modulates the APR during HS recovery through interactions with the liver IL-6-STAT3 pathway of SAA3 regulation. C1 [Leon, Lisa R.; Dineen, Shauna; Blaha, Michael D.] US Army Res Inst Environm Med, Thermal Mt Med Div, Natick, MA 01760 USA. [Rodriguez-Fernandez, Maria] Univ Calif Santa Barbara, Dept Chem Engn, Santa Barbara, CA 93106 USA. [Clarke, David C.] MIT, Dept Biol Engn, Cambridge, MA 02139 USA. [Clarke, David C.] MIT, Ctr Cellular Decis Proc, Cambridge, MA 02139 USA. RP Leon, LR (reprint author), US Army Res Inst Environm Med, Thermal Mt Med Div, Kansas St,Bldg 42, Natick, MA 01760 USA. EM lisa.r.leon.civ@mail.mil RI Rodriguez-Fernandez, Maria/I-7193-2016 OI Rodriguez-Fernandez, Maria/0000-0003-1966-2920 FU United States Army Medical Research and Materiel Command FX This research was funded by United States Army Medical Research and Materiel Command. This article has been approved for public release. Distribution of this article is unlimited. NR 32 TC 6 Z9 7 U1 1 U2 4 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 0363-6119 EI 1522-1490 J9 AM J PHYSIOL-REG I JI Am. J. Physiol.-Regul. Integr. Comp. Physiol. PD DEC PY 2013 VL 305 IS 12 BP R1421 EP R1432 DI 10.1152/ajpregu.00127.2013 PG 12 WC Physiology SC Physiology GA 276KR UT WOS:000328749700002 PM 24133099 ER PT J AU Yoon, IK Srikiatkhachorn, A Hermann, L Buddhari, D Scott, TW Jarman, RG Aldstadt, J Nisalak, A Thammapalo, S Bhoomiboonchoo, P Mammen, MP Green, S Gibbons, RV Endy, TP Rothman, AL AF Yoon, In-Kyu Srikiatkhachorn, Anon Hermann, Laura Buddhari, Darunee Scott, Thomas W. Jarman, Richard G. Aldstadt, Jared Nisalak, Ananda Thammapalo, Suwich Bhoomiboonchoo, Piraya Mammen, P. Mammen Green, Sharone Gibbons, Robert V. Endy, Timothy P. Rothman, Alan L. TI Characteristics of Mild Dengue Virus Infection in Thai Children SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID PRIMARY-SCHOOL CHILDREN; DISEASE SEVERITY; LABORATORY INDICATORS; HEMORRHAGIC-FEVER; KAMPHAENG PHET; FEATURES; EPIDEMIOLOGY; VILLAGES; SAMPLES; BURDEN AB A four-year longitudinal cohort and geographic cluster study in rural Thailand was conducted to characterize the clinical spectrum of dengue virus (DENY) infection. Symptomatic DENV infections in the cohort were detected by active school absence-based surveillance that triggered cluster investigations around ill cohort children. Data from 189 cohort children with symptomatic DENV infection and 126 contact children in the clusters with DENY infection were analyzed. Of injected contacts, only 19% were asymptomatic; 81% were symptomatic, but only 65.9% reported fever. Symptom-based case definitions were unreliable for diagnosis. Symptomatic infections in contacts were milder with lower DENV RNA levels than the cohort. Infections in contacts with fever history were more likely to have detectable DENV RNA than infections without fever history. Mild infections identified by cluster investigations account for a major proportion of all DENY infections. These findings are relevant for disease burden assessments, transmission modeling, and determination of vaccine impact. C1 [Yoon, In-Kyu] Armed Forces Res Inst Med Sci, Dept Virol, Bangkok 10400, Thailand. Univ Massachusetts, Sch Med, Worcester, MA USA. Univ Toronto, Dept Med, Toronto, ON, Canada. Univ Calif Davis, Dept Entomol, Davis, CA 95616 USA. SUNY Buffalo, Dept Geog, Buffalo, NY 14260 USA. Minist Publ Hlth, Dept Med Sci, Bur Epidemiol, Nonthaburi, Thailand. SUNY Syracuse, Dept Infect Dis, Syracuse, NY USA. Univ Rhode Isl, Inst Immunol & Informat, Providence, RI 02908 USA. NIH, Fogarty Int Ctr, Bethesda, MD 20892 USA. RP Yoon, IK (reprint author), Armed Forces Res Inst Med Sci, Dept Virol, Bangkok 10400, Thailand. EM yooni@afrims.org RI Aldstadt, Jared/A-8508-2009 OI Aldstadt, Jared/0000-0001-9162-7439 FU National Institutes of Health [P01 AI34533, R01 GM083224]; U.S. Military Infectious Diseases Research Program [S0016-04-AF]; Bill and Melinda Gates Foundation Global Health Program [OPP52250]; Canadian Institutes of Health Research Fellowship FX This research was supported, in part, by the National Institutes of Health (grants P01 AI34533 and R01 GM083224), the U.S. Military Infectious Diseases Research Program (grant S0016-04-AF), the Bill and Melinda Gates Foundation Global Health Program (grant OPP52250), and the Canadian Institutes of Health Research Fellowship (Laura Hermann). The funding source had no role in the study design, data collection, analysis and interpretation, manuscript writing, or manuscript submission for publication. NR 28 TC 6 Z9 6 U1 0 U2 9 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 EI 1476-1645 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2013 VL 89 IS 6 BP 1081 EP 1087 DI 10.4269/ajtmh.13-0424 PG 7 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 276CQ UT WOS:000328726100007 PM 24127167 ER PT J AU Harrison, GF Foley, DH Rueda, LM Melanson, VR Wilkerson, RC Long, LS Richardson, JH Klein, TA Kim, HC Lee, WJ AF Harrison, Genelle F. Foley, Desmond H. Rueda, Leopoldo M. Melanson, Vanessa R. Wilkerson, Richard C. Long, Lewis S. Richardson, Jason H. Klein, Terry A. Kim, Heung-Chul Lee, Won-Ja TI Short Report: Plasmodium-Specific Molecular Assays Produce Uninterpretable Results and Non-Plasmodium spp. Sequences in Field-Collected Anopheles Vectors SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID POLYMERASE-CHAIN-REACTION; HUMAN MALARIA PARASITES; VIVAX; PCR AB The Malaria Research and Reference Reagent Resource recommended PLF/UNR/VIR polymerase chain reaction (PCR) was used to detect Plasmodium vivax in Anopheles spp. mosquitoes collected in South Korea. Samples that were amplified were sequenced and compared with known Plasmodium spp. by using the PlasmoDB.org Basic Local Alignment Search Tool/n and the National Center for Biotechnology Information Basic Local Alignment Search Tool/n tools. Results show that the primers PLF/UNR/VIR used in this PCR can produce uninterpretable results and non-specific sequences in field-collected mosquitoes. Three additional PCRs (PLU/VIV, specific for 18S small subunit ribosomal DNA; Pvr47, specific for a nuclear repeat; and GDCW/PLAS, specific for the mitochondrial marker, cytB) were then used to find a more accurate and interpretable assay. Samples that were amplified were again sequenced. The PLU/VIV and Pvr47 assays showed cross-reactivity with non-Plasmodium spp. and an arthropod fungus (Zoophthora lanceolata). The GDCW/PLAS assay amplified only Plasmodium spp. but also amplified the non-human specific parasite P. berghei from an Anopheles belenrae mosquito. Detection of P. berghei in South Korea is a new finding. C1 [Harrison, Genelle F.; Foley, Desmond H.; Rueda, Leopoldo M.; Melanson, Vanessa R.; Wilkerson, Richard C.; Long, Lewis S.; Richardson, Jason H.] Walter Reed Army Inst Res, Entomol Branch, Silver Spring, MD 20910 USA. [Klein, Terry A.] Publ Hlth Command Reg Pacific, Camp Zama, Japan. [Kim, Heung-Chul] 65th Med Brigade, Multifunct Med Support Battal 168, Med Detachment 5, Seoul, South Korea. [Kim, Heung-Chul; Lee, Won-Ja] Korea Ctr Dis Control & Prevent, Div Malaria & Parasit Dis, Seoul, South Korea. RP Harrison, GF (reprint author), Walter Reed Army Inst Res, Entomol Branch, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM gh0106a@american.edu; Desfoley@si.edu; RuedaPol@si.edu; Vanessa.melanson@us.army.mil; WilkersonR@si.edu; Lewis.S.Long@us.army.mil; Jason.H.Richarcdson@us.army.mil; Terry.A.Klein2.civ@mail.mil; hungchol.kim2.ln@mail.mil; Leewonja@gtnail.com OI Foley, Desmond/0000-0001-7525-4601 FU Armed Forces Health Surveillance Center, Global Emerging Infections Surveillance and Response Systems, Silver Spring, MD FX Thus study was supported by Armed Forces Health Surveillance Center, Global Emerging Infections Surveillance and Response Systems, Silver Spring, MD. NR 14 TC 4 Z9 5 U1 0 U2 2 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 EI 1476-1645 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2013 VL 89 IS 6 BP 1117 EP 1121 DI 10.4269/ajtmh.12-0581 PG 5 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 276CQ UT WOS:000328726100011 PM 24189365 ER PT J AU Switzer, AD McMillan-Cole, AC Kasten, RW Stuckey, MJ Kass, PH Chomel, BB AF Switzer, Alexandra D. McMillan-Cole, Audrey C. Kasten, Rickie W. Stuckey, Matthew J. Kass, Philip H. Chomel, Bruno B. TI Bartonella and Toxoplasma Infections in Stray Cats from Iraq SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID VINSONII SUBSP BERKHOFFII; MOLECULAR EPIDEMIOLOGY; DOMESTIC CATS; GONDII; HENSELAE; DISEASE; FELINE; SEROPREVALENCE; PREVALENCE; RESERVOIR AB Because of overpopulation, stray/feral cats were captured on military bases in Iraq as part of the US Army Zoonotic Disease Surveillance Program. Blood samples were collected from 207 cats, mainly in Baghdad but also in North and West Iraq, to determine the prevalence of Bartonella and Toxoplasma infections. Nine (4.3%) cats, all from Baghdad, were bacteremic with B. henselae type I. Seroprevalence was 30.4% for T. gondii, 15% for B. henselae, and 12.6% for B. clarridgeiae. Differences in Bartonella prevalence by location were statistically significant, because most of the seropositive cats were from Baghdad. There was no association between T. gondii seropositivity and either of the two Bartonella species surveyed. This report is the first report on the prevalence of Bartonella and T. gondii among stray cats in Iraq, which allows for better evaluation of the zoonotic risk potential to the Iraqi people and deployed military personnel by feral cat colonies. C1 [Switzer, Alexandra D.] Stanford Sch Med, Dept Microbiol & Immunol, Stanford, CA USA. [McMillan-Cole, Audrey C.] Tripler Army Med Ctr, Publ Hlth Command Reg Pacific, Honolulu, HI 96859 USA. [Kasten, Rickie W.; Stuckey, Matthew J.; Kass, Philip H.; Chomel, Bruno B.] Univ Calif Davis, Sch Vet Med, Dept Populat Hlth & Reprod, Davis, CA 95616 USA. RP Chomel, BB (reprint author), Univ Calif Davis, Sch Vet Med, Dept Populat Hlth & Reprod, Davis, CA 95616 USA. EM adswitzer@ucdavis.edu; audrey.mcmillancole@us.army.mil; rwkasten@ucdavis.edu; mstuckey@ucdavis.edu; phkass@ucdavis.edu; bbchomel@ucdavis.edu FU US Army contract (U.S. Army Medical Research Acquisition Activity/Walter Reed Army Institute of Research) [W81XWH10P0215] FX The project was funded under a US Army contract (U.S. Army Medical Research Acquisition Activity/Walter Reed Army Institute of Research Contract W81XWH10P0215). The funders had no role in study design, data collection and analysis, or preparation of the manuscript. Sample collection was performed by the military under the supervision of US Army Zoonotic Disease Surveillance Program. Decision to publish was approved by Public Affairs and Dr. McMillan-Cole, supervisors (e-mail of Dr. McMillan-Cole of April 19,2012). NR 35 TC 2 Z9 2 U1 3 U2 10 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 EI 1476-1645 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2013 VL 89 IS 6 BP 1219 EP 1224 DI 10.4269/ajtmh.13-0353 PG 6 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 276CQ UT WOS:000328726100028 PM 24062480 ER PT J AU Rakesh, V Stallings, JD Helwig, BG Leon, LR Jackson, DA Reifman, J AF Rakesh, Vineet Stallings, Jonathan D. Helwig, Bryan G. Leon, Lisa R. Jackson, David A. Reifman, Jaques TI A 3-D mathematical model to identify organ-specific risks in rats during thermal stress SO JOURNAL OF APPLIED PHYSIOLOGY LA English DT Article DE computational modeling; core temperature; finite element method; multiorgan dysfunction syndrome; radiotelemetry ID SPONTANEOUS MUSCULAR ACTIVITY; SPRAGUE-DAWLEY RAT; HEAT-STROKE; EXPERIMENTAL HEATSTROKE; CIRCADIAN-RHYTHMS; CORE TEMPERATURE; BLOOD-FLOW; SHORT-TERM; ENVIRONMENTAL-TEMPERATURE; BODY-TEMPERATURE AB Early prediction of the adverse outcomes associated with heat stress is critical for effective management and mitigation of injury, which may sometimes lead to extreme undesirable clinical conditions, such as multiorgan dysfunction syndrome and death. Here, we developed a computational model to predict the spatiotemporal temperature distribution in a rat exposed to heat stress in an attempt to understand the correlation between heat load and differential organ dysfunction. The model includes a three-dimensional representation of the rat anatomy obtained from medical imaging and incorporates the key mechanisms of heat transfer during thermoregulation. We formulated a novel approach to estimate blood temperature by accounting for blood mixing from the different organs and to estimate the effects of the circadian rhythm in body temperature by considering day-night variations in metabolic heat generation and blood perfusion. We validated the model using in vivo core temperature measurements in control and heat-stressed rats and other published experimental data. The model predictions were within 1 SD of the measured data. The liver demonstrated the greatest susceptibility to heat stress, with the maximum temperature reaching 2 degrees C higher than the measured core temperature and 95% of its volume exceeding the targeted experimental core temperature. Other organs also attained temperatures greater than the core temperature, illustrating the need to monitor multiple organs during heat stress. The model facilitates the identification of organ-specific risks during heat stress and has the potential to aid in the development of improved clinical strategies for thermal-injury prevention and management. C1 [Rakesh, Vineet; Reifman, Jaques] US Army Med Res & Mat Command, Telemed & Adv Technol Res Ctr, Dept Def Biotechnol High Performance Comp Softwa, Ft Detrick, MD 21702 USA. [Stallings, Jonathan D.; Jackson, David A.] US Army Ctr Environm Hlth Res, Biomarkers Program, Ft Detrick, MD USA. [Helwig, Bryan G.; Leon, Lisa R.] US Army Res Inst Environm Med, Thermal Mt Med Div, Natick, MA USA. RP Reifman, J (reprint author), US Army Med Res & Mat Command, MCMR TT, DoD Biotechnol High Performance Comp Software App, Telemed & Adv Technol Res Ctr, 504 Scott St, Ft Detrick, MD 21702 USA. EM jaques.reifman.civ@mail.mil RI Jackson, David/E-9984-2014; OI Stallings, Jonathan/0000-0002-6430-5888 FU U. S. Army Network Science Initiative; U. S. Army Medical Research and Materiel Command FX The research was supported by the U. S. Army Network Science Initiative and the Military Operational Medicine Research Program, U. S. Army Medical Research and Materiel Command, Ft. Detrick, Maryland. NR 90 TC 5 Z9 6 U1 1 U2 7 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 8750-7587 EI 1522-1601 J9 J APPL PHYSIOL JI J. Appl. Physiol. PD DEC PY 2013 VL 115 IS 12 BP 1822 EP 1837 DI 10.1152/japplphysiol.00589.2013 PG 16 WC Physiology; Sport Sciences SC Physiology; Sport Sciences GA 277VR UT WOS:000328847900010 PM 24072412 ER PT J AU Kiesel, J Schmalz, B Brown, GL Fohrer, N AF Kiesel, Jens Schmalz, Britta Brown, Gary L. Fohrer, Nicola TI Application of a hydrological-hydraulic modelling cascade in lowlands for investigating water and sediment fluxes in catchment, channel and reach SO JOURNAL OF HYDROLOGY AND HYDROMECHANICS LA English DT Article DE SWAT; HEC-RAS; AdH; SEDLIB; Hydrology; Sediment transport; Multiple scales ID SUSPENDED SEDIMENT; BANK EROSION; AGRICULTURAL CATCHMENTS; DELIVERY; RIVERS; LOAD; ECOHYDROLOGY; ECOSYSTEMS; TRANSPORT; RUNOFF AB This study shows a comprehensive simulation of water and sediment fluxes from the catchment to the reach scale. We describe the application of a modelling cascade in a well researched study catchment through connecting state-of-the-art public domain models in ArcGIS. Three models are used consecutively: (1) the hydrological model SWAT to evaluate water balances, sediment input from fields and tile drains as a function of catchment characteristics; (2) the one-dimensional hydraulic model HEC-RAS to depict channel erosion and sedimentation along a 9 km channel one-dimensionally; and (3) the two-dimensional hydraulic model AdH for simulating detailed substrate changes in a 230 m long reach section over the course of one year. Model performance for the water fluxes is very good, sediment fluxes and substrate changes are simulated with good agreement to observed data. Improvement of tile drain sediment load, simulation of different substrate deposition events and carrying out data sensitivity tests are suggested as future work. Main advantages that can be deduced from this study are separate representation of field, drain and bank erosion processes; shown adaptability to lowland catchments and transferability to other catchments; usability of the model's output for habitat assessments. C1 [Kiesel, Jens; Schmalz, Britta; Fohrer, Nicola] Univ Kiel, Inst Nat Resource Conservat, Dept Hydrol & Water Resources Management, D-24118 Kiel, Germany. [Brown, Gary L.] USACE, CHL, ERDC, Vicksburg, MS 39108 USA. RP Kiesel, J (reprint author), Univ Kiel, Inst Nat Resource Conservat, Dept Hydrol & Water Resources Management, Olshausenstr 75, D-24118 Kiel, Germany. EM jkiesel@hydrology.uni-kiel.de RI Fohrer, Dr., Nicola/C-6313-2011 OI Fohrer, Dr., Nicola/0000-0002-7456-6301 FU German Federal Environmental Foundation (DBU) [20007/897]; German Academic Exchange Service (DAAD) [D/08/43893] FX The first author has been funded by the German Federal Environmental Foundation (DBU, research grant 20007/897) and in part by the German Academic Exchange Service (DAAD, research grant D/08/43893). We thank Jonathan R. Shewchuk for supplying the Triangle mesh generator, which is part of ArcADH, as an open source program. We also thank Charlie Berger, Jennifer Tate and Gaurav Savant for their guidance on the application of AdH. We appreciate the comments of two anonymous reviewers that improved the quality of the paper. NR 76 TC 9 Z9 9 U1 3 U2 24 PU VEDA, SLOVAK ACAD SCIENCES PI BRATISLAVA PA DUBRAVSKA CESTA 9, 842 34 BRATISLAVA, SLOVAKIA SN 0042-790X EI 1338-4333 J9 J HYDROL HYDROMECH JI J. Hydrol. Hydromech. PD DEC PY 2013 VL 61 IS 4 BP 334 EP 346 DI 10.2478/johh-2013-0042 PG 13 WC Water Resources SC Water Resources GA 272XT UT WOS:000328497300010 ER PT J AU McGuire, JM Wilson, JT AF McGuire, Jason M. Wilson, John Tyler TI Reply: Possible Confounding by Mefloquine in the Association of Emergence Delirium With PTSD and TBI Among Combat Veterans SO JOURNAL OF PERIANESTHESIA NURSING LA English DT Letter ID RISK-FACTORS C1 [McGuire, Jason M.; Wilson, John Tyler] US Navy, Nurse Corps, Bethesda, MD USA. [McGuire, Jason M.; Wilson, John Tyler] Uniformed Serv Univ Hlth Sci, Grad Sch Nursing, Bethesda, MD 20814 USA. [Wilson, John Tyler] US Army, Nurse Corps, Bethesda, MD USA. RP McGuire, JM (reprint author), US Navy, Nurse Corps, Bethesda, MD USA. EM jason.mcguire@usuhs.edu; john.wilson@usuhs.edu NR 6 TC 1 Z9 1 U1 0 U2 2 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1089-9472 EI 1532-8473 J9 J PERIANESTH NURS JI J. PeriAnesthesia Nurs. PD DEC PY 2013 VL 28 IS 6 BP 335 EP 336 DI 10.1016/j.jopan.2013.09.007 PG 2 WC Nursing SC Nursing GA 268PD UT WOS:000328182100004 PM 24267620 ER PT J AU Neesanant, P Sirinarumitr, T Chantakru, S Boonyaprakob, U Chuwongkomon, K Bodhidatta, L Sethabutr, O Abente, EJ Supawat, K Mason, CJ AF Neesanant, Pimmnapar Sirinarumitr, Theerapol Chantakru, Siriruk Boonyaprakob, Ukadaj Chuwongkomon, Kaittawee Bodhidatta, Ladaporn Sethabutr, Orntipa Abente, Eugenio J. Supawat, Krongkaew Mason, Carl J. TI Optimization of one-step real-time reverse transcription-polymerase chain reaction assays for norovirus detection and molecular epidemiology of noroviruses in Thailand SO JOURNAL OF VIROLOGICAL METHODS LA English DT Article DE Norovirus; Diagnosis; Real-time RT-PCR; Molecular epidemiology; Thailand ID NORWALK-LIKE VIRUSES; ROUND-STRUCTURED VIRUSES; GENOGROUP-II NOROVIRUSES; ACUTE GASTROENTERITIS; GENETIC DIVERSITY; CHIANG-MAI; PCR ASSAY; HUMAN CALICIVIRUSES; GII.4 NOROVIRUS; STOOL SAMPLES AB Noroviruses (NoVs) are an important human pathogen associated with acute viral gastroenteritis worldwide. NoVs display a significant amount of genetic heterogeneity, making it difficult to develop comprehensive detection assays. In this study, primer sets and probes were designed for a TaqMan (R)-based real-time reverse transcription-polymerase chain reaction (RT-PCR) for norovirus detection purposes. The assay was optimized and utilized as a multiplex real-time RT-PCR assay for genogroup I (GI) detection, and a singleplex real-time RT-PCR assay for genogroup II (GII) detection. The assays showed high specificity for NoV detection and no cross-reactivity was observed between GI and GII. The detection limit of the assay was as low as 10 and 50 RNA copies per reaction for GI and GII, respectively. The optimized protocol was employed to assess the presence of NoV strains in clinical samples collected throughout Thailand during December 2005 to November 2006. The percentage of NoV infections among children with acute gastroenteritis (case) was 23.8% (119/500) and for children without acute gastroenteritis (control) it was 6.8% (30/441). The frequency of NoV infections varied geographically, with the highest frequency observed in the central region and the lowest frequency in the northern region (P>0.0001). Of the 149 positive case and control specimens, GII was found to be the predominant genogroup (98.6%),Partial capsid sequences were successfully obtained from 67 NoV-positive specimens and a phylogenetic analysis was performed to genotype the viral strains. GII.4 was the most common genotype detected. (C) 2013 The Authors. Published by Elsevier B.V. All rights reserved. C1 [Neesanant, Pimmnapar] Kasetsart Univ, Dept Grad Sch, Interdisciplinary Grad Program, Bangkok 10900, Thailand. [Neesanant, Pimmnapar; Bodhidatta, Ladaporn; Sethabutr, Orntipa; Abente, Eugenio J.; Mason, Carl J.] Armed Forces Res Inst Med Sci, Dept Enter Dis, Bangkok 10400, Thailand. [Sirinarumitr, Theerapol; Chantakru, Siriruk; Boonyaprakob, Ukadaj] Kasetsart Univ, Fac Vet Med, Bangkok 10900, Thailand. [Chuwongkomon, Kaittawee] Kasetsart Univ, Fac Sci, Bangkok, Thailand. [Supawat, Krongkaew] NIH, Minist Publ Hlth, Dept Med Sci, Nonthaburi 11000, Thailand. RP Sirinarumitr, T (reprint author), Kasetsart Univ, Fac Vet Med, 50 Ngam Wong Wan Rd, Bangkok 10900, Thailand. EM fvettps@yahoo.com OI Abente, Eugenio/0000-0002-3390-2786 FU Graduate School, Kasetsart University; National Institute of Allergy and Infectious Diseases [Y1-A1-4906-09]; Armed Forces Health Surveillance Center-Global Emerging Infections Surveillance and Response System (AFHSC-GEIS), Silver spring, MD, USA FX This study was supported by grants from the Graduate School, Kasetsart University, the National Institute of Allergy and Infectious Diseases (Y1-A1-4906-09) and the Armed Forces Health Surveillance Center-Global Emerging Infections Surveillance and Response System (AFHSC-GEIS), Silver spring, MD, USA. NR 52 TC 8 Z9 8 U1 0 U2 5 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0166-0934 EI 1879-0984 J9 J VIROL METHODS JI J. Virol. Methods PD DEC PY 2013 VL 194 IS 1-2 BP 317 EP 325 DI 10.1016/j.jviromet.2013.08.033 PG 9 WC Biochemical Research Methods; Biotechnology & Applied Microbiology; Virology SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology; Virology GA 273FV UT WOS:000328521600047 PM 24070785 ER PT J AU Rao, SS Prater, JT Wu, F Shelton, CT Maria, JP Narayan, J AF Rao, S. S. Prater, J. T. Wu, Fan Shelton, C. T. Maria, J. -P. Narayan, J. TI Interface Magnetism in Epitaxial BiFeO3-La0.7Sr0.3MnO3 Heterostructures Integrated on Si(100) SO NANO LETTERS LA English DT Article DE Coerceive field; exchange bias; interface magnetic moment; domain matching epitaxy and multiferroics ID EXCHANGE BIAS; MULTIFERROIC BIFEO3; THIN-FILMS; ANISOTROPY; GROWTH AB We report on the heteroepitaxial growth of ferroelectric (FE)-antiferromagnetic (AFM) BiFeO3 (BFO) on ferromagnetic La0.7Sr0.3MnO3 (LSMO), integrated on Si(100) using pulsed laser deposition via the domain matching epitaxy paradigm. The BFO/LSMO films were epitaxially grown on Si(100) by introducing epitaxial layers of SrTiO3/MgO/TiN. X-ray diffraction, scanning electron microscopy, high-resolution transmission electron microscopy, X-ray photo absorption spectroscopy, and atomic force microscopy were employed to fully characterize the samples. Furthermore, we have investigated the magnetic behavior of this five layer heterostructure, in which a d(5) system (Fe3+) manifested in FE-AFM BFO is epitaxially conjoined at the interface to a multivalent transition metal ion such as Mn3+/Mn4+ in LSMO. The temperature- and magnetic field-dependent magnetization measurements reveal an unexpected enhancement in magnetic moment and improved magnetic hysteresis squareness originating from the BFO/LSMO interface. We observe a stronger temperature dependence of H-EB when the polarity of field cooling is negative as compared to positive field cooling. We believe such an enhancement in magnetic moment and magnetic coupling is likely directly related to an electronic orbital reconstruction at the interface and complex interplay between orbital and spin degrees of freedom, similar to what has previously been reported in the literature. Future work will involve the linearly polarized X-ray absorption measurements to prove this hypothesis. This work represents a starting step toward the realization of magneto-electronic devices integrated with Si(100). C1 [Rao, S. S.; Prater, J. T.] Army Res Off, Div Mat Sci, Res Triangle Pk, NC 27709 USA. [Rao, S. S.; Prater, J. T.; Wu, Fan; Shelton, C. T.; Maria, J. -P.; Narayan, J.] N Carolina State Univ, Dept Mat Sci & Engn, Raleigh, NC 27695 USA. RP Rao, SS (reprint author), Army Res Off, Div Mat Sci, Res Triangle Pk, NC 27709 USA. EM ssingam@ncsu.edu RI Wu, Fan/D-9814-2014 OI Wu, Fan/0000-0001-5000-0592 FU National Academy of Science (NAS), USA; Army Research Office [W911NF-04-D-0003.]; State of North Carolina; National Science Foundation FX SSR acknowledges National Academy of Science (NAS), USA for awarding the NRC postdoctoral research associate fellowship. We thank N Sudhakar and P Gupta for their valuable experimental help. The authors are pleased to acknowledge the support of the Army Research Office under Grant W911NF-04-D-0003. Also, the authors acknowledge the use of the Analytical Instrumentation Facility (AIF) at North Carolina State University, which is supported by the State of North Carolina and the National Science Foundation. NR 21 TC 25 Z9 25 U1 13 U2 176 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1530-6984 EI 1530-6992 J9 NANO LETT JI Nano Lett. PD DEC PY 2013 VL 13 IS 12 BP 5814 EP 5821 DI 10.1021/nl4023435 PG 8 WC Chemistry, Multidisciplinary; Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied; Physics, Condensed Matter SC Chemistry; Science & Technology - Other Topics; Materials Science; Physics GA 272CZ UT WOS:000328439200009 PM 24199647 ER PT J AU Mok, JM Jackson, KL Fang, R Freedman, BA AF Mok, James M. Jackson, Keith L. Fang, Raymond Freedman, Brett A. TI Effect of vacuum spine board immobilization on incidence of pressure ulcers during evacuation of military casualties from theater SO SPINE JOURNAL LA English DT Article DE Spinal immobilization; Transport; Military medicine; Spinal cord injury; Combat ID TISSUE-INTERFACE PRESSURES; STABILITY; INJURY; TRAUMA AB BACKGROUND CONTEXT: In the summer of 2009, the vacuum spine board (VSB) was designated by the US Air Force as the preferred method of external spinal immobilization during aeromedical transport of patients with suspected unstable thoracolumbar spine fractures. One purported advantage of the VSB is that, by distributing weight over a larger surface area, it decreases the risk of skin pressure ulceration. PURPOSE: To examine whether the rate of pressure ulcers has changed since the introduction of the VSB. STUDY DESIGN: Retrospective cohorts. PATIENT SAMPLE: Injured US service members undergoing spinal immobilization during evacuation from the Iraq and Afghanistan theaters to Landstuhl, Germany. OUTCOME MEASURES: Presence and stage of pressure ulceration, and deterioration in neurologic status. METHODS: Records of the initial 60 patients medically evacuated on the VSB to Landstuhl Regional Medical Center were retrospectively analyzed for patient demographics, injury characteristics, and incidence of pressure injury. The incidence of pressure ulcers after the use of VSB was compared with that in a historical control consisting of 30 patients with unstable spinal injuries evacuated before the introduction of the VSB. No sources of external funding were used for this investigation. RESULTS: The combined cohort had a mean age of 28.8 years and mean Injury Severity Score (ISS) of 20.63 and comprised 96% men. Most injury mechanisms were blunt (58%). The rate of neurological injury was 19%. There were no cases of progressive neurological deficit or deformity in either cohort. In the VSB group, using a broad definition of pressure ulcer, incidence was 13 of 60 patients (22%). Using a strict definition, incidence was eight of 60 (13%): five Stage I and three Stage II. In the non-VSB group, incidence of pressure ulcers was three of 30 (10%), using either definition, all Stage II. Difference in incidence between the groups was not statistically significant. Intubated patients had a significantly higher incidence of pressure ulcers. CONCLUSION: Both the VSB and historic means (non-VSB) of spinal immobilization appear to be safe and produce only transient morbidity despite an average of 9 to 10 hours of transport. Intubated status was identified as the most important risk factor for the development of a pressure ulcer. Published by Elsevier Inc. C1 [Mok, James M.] Madigan Army Med Ctr, Dept Surg, Orthopaed Surg Serv, Tacoma, WA 98431 USA. [Jackson, Keith L.] Dwight D Eisenhower Army Med Ctr, Dept Orthopaed Surg & Rehabil Serv, Ft Gordon, GA 30809 USA. [Fang, Raymond] Univ Maryland, Med Ctr, R Adams Cowley Shock Trauma Ctr, US Air Force Ctr Sustainment Trauma & Readiness S, Baltimore, MD 21201 USA. [Freedman, Brett A.] Landstuhl Reg Med Ctr, Spine & Neurosurg Serv, D-66849 Landstuhl, Germany. RP Mok, JM (reprint author), Madigan Army Med Ctr, Dept Surg, Orthopaed Surg Serv, Bldg 9040A Fitzsimmons Dr, Tacoma, WA 98431 USA. EM james.mok@amedd.army.mil FU US Army FX JMM: Nothing to disclose. KLJ: Stock Ownership: J and M Shuler Medical, Inc. (10,000 shares); Grant: US Army ( I, Paid directly to institution/employer). RF: Nothing to disclose. BAF: Nothing to disclose. NR 21 TC 3 Z9 3 U1 2 U2 7 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1529-9430 EI 1878-1632 J9 SPINE J JI Spine Journal PD DEC PY 2013 VL 13 IS 12 BP 1801 EP 1808 DI 10.1016/j.spinee.2013.05.028 PG 8 WC Clinical Neurology; Orthopedics SC Neurosciences & Neurology; Orthopedics GA 272XG UT WOS:000328495800019 PM 23816354 ER PT J AU Peela, NR Zheng, WQ Lee, IC Karim, AM Vlachos, DG AF Peela, Nageswara Rao Zheng, Weiqing Lee, Ivan C. Karim, Ayman M. Vlachos, Dionisios G. TI Core-Shell Nanocatalyst Design by Combining High-Throughput Experiments and First-Principles Simulations SO CHEMCATCHEM LA English DT Article DE alloys; computational chemistry; density functional calculations; high-throughput experiments; oxidation ID TOTAL-ENERGY CALCULATIONS; EVANS-POLANYI RELATION; WAVE BASIS-SET; HETEROGENEOUS CATALYSIS; METAL-SURFACES; 1ST PRINCIPLES; BIMETALLIC CATALYSTS; AMMONIA-SYNTHESIS; IN-SITU; OXIDATION AB Despite significant research efforts, designing bimetallic catalysts rationally remains a challenging task. Herein, we combine the strengths of high-throughput experiments and DFT calculations synergistically to design new core-shell bimetallic catalysts. The total oxidation of propane is used as a probe, proof-of-concept reaction. The methodology is successful in designing three bimetallic catalysts. Of these catalysts, AgPd is cheaper, more active than the existing most active single-metal catalyst (Pt), and stable under the reaction conditions. Extended X-ray absorption fine structure characterization confirms the formation of a bimetallic alloy. This study provides a path forward for designing bimetallic catalysts rationally for vapor phase metal-catalyzed reactions. C1 [Peela, Nageswara Rao; Zheng, Weiqing; Vlachos, Dionisios G.] Univ Delaware, Catalysis Ctr Energy Innovat, Dept Chem & Biomol Engn, Newark, DE 19716 USA. [Lee, Ivan C.] US Army, Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA. [Karim, Ayman M.] Pacific NW Natl Lab, Inst Integrated Catalysis, Richland, WA 99352 USA. RP Vlachos, DG (reprint author), Univ Delaware, Catalysis Ctr Energy Innovat, Dept Chem & Biomol Engn, Newark, DE 19716 USA. EM vlachos@udel.edu RI Peela, Nageswara/L-4895-2013; Karim, Ayman/G-6176-2012; Zheng, Weiqing/C-8620-2014; OI Karim, Ayman/0000-0001-7449-542X; Vlachos, Dionisios/0000-0002-6795-8403 FU Army Research Laboratory; DFT [W911NF-10-2-0047]; Catalysis Center for Energy Innovation; Energy Frontier Research Center; U.S. Department of Energy, Office of Science, Office of Basic Energy Sciences [DE-SC0001004]; U.S. Department of Energy, Office of Basic Energy Sciences [DE-FG02-05ER15688]; Chemical Imaging Initiative at Pacific Northwest National Laboratory (PNNL) FX N.R.P., I.C.L., and D.G.V. were sponsored by the Army Research Laboratory for their catalyst synthesis and characterization, kinetic experiments, and DFT under the Cooperative Agreement Number W911NF-10-2-0047. The views and conclusions contained herein are those of the authors and should not be interpreted as representing the official policies, either expressed or implied, of the Army Research Laboratory or the U.S. government. The U.S. government is authorized to reproduce and distribute reprints for government purposes notwithstanding any copyright notation hereon. The microscopy study was conducted by W.Z. and was supported by the Catalysis Center for Energy Innovation, an Energy Frontier Research Center funded by the U.S. Department of Energy, Office of Science, Office of Basic Energy Sciences under award no. DE-SC0001004. The EXAFS study was performed by A.M.K. at the National Synchrotron Light Source, Brookhaven National Laboratory, and was supported by the U.S. Department of Energy, Office of Basic Energy Sciences (grant no. DE-FG02-05ER15688). The research described herein was supported, in part, by the Chemical Imaging Initiative at Pacific Northwest National Laboratory (PNNL). It was performed under the Laboratory Directed Research and Development Program at PNNL, a multiprogram national laboratory operated by Battelle for the U.S. Department of Energy. NR 61 TC 2 Z9 2 U1 2 U2 46 PU WILEY-V C H VERLAG GMBH PI WEINHEIM PA BOSCHSTRASSE 12, D-69469 WEINHEIM, GERMANY SN 1867-3880 EI 1867-3899 J9 CHEMCATCHEM JI ChemCatChem PD DEC PY 2013 VL 5 IS 12 BP 3712 EP 3718 DI 10.1002/cctc.201300553 PG 7 WC Chemistry, Physical SC Chemistry GA 257YT UT WOS:000327424500039 ER PT J AU Greer, AH Yong, T Fennell, K Moustafa, YW Fowler, M Galiano, F Ng, SW Berkowitz, RS Cardelli, J Meyers, S Davis, JN AF Greer, Adam H. Yong, Thomas Fennell, Katie Moustafa, Yara W. Fowler, Marcie Galiano, Floyd Ng, Shu-Wing Berkowitz, Ross S. Cardelli, James Meyers, Shari Davis, J. Nathan TI Knockdown of Core Binding Factor beta Alters Sphingolipid Metabolism SO JOURNAL OF CELLULAR PHYSIOLOGY LA English DT Article ID ONCOGENE-INDUCED SENESCENCE; CANCER-CELLS; RUNX GENES; OXIDATIVE STRESS; PROSTATE-CANCER; OVARIAN-CANCER; DNA-BINDING; CBF-BETA; AUTOPHAGY; TRANSCRIPTION AB Core binding factor (CBF) is a heterodimeric transcription factor containing one of three DNA-binding proteins of the Runt-related transcription factor family (RUNX1-3) and the non-DNA-binding protein, CBF. RUNX1 and CBF are the most common targets of chromosomal rearrangements in leukemia. CBF has been implicated in other cancer types; for example RUNX1 and RUNX2 are implicated in cancers of epithelial origin, including prostate, breast, and ovarian cancers. In these tumors, CBF is involved in maintaining the malignant phenotype and, when highly over-expressed, contributes to metastatic growth in bone. Herein, lentiviral delivery of CBF-specific shRNAs was used to achieve a 95% reduction of CBF in an ovarian cancer cell line. This drastic reduction in CBF expression resulted in growth inhibition that was not associated with a cell cycle block or an increase in apoptosis. However, CBF silencing resulted in increased autophagy and production of reactive oxygen species (ROS). Since sphingolipid and ceramide metabolism regulates non-apoptotic cell death, autophagy, and ROS production, fumonsin B1 (FB1), an inhibitor of ceramide synthase, was used to alter ceramide production in the CBF-silenced cells. FB1 treatment inhibited the CBF-dependent increase in autophagy and provided a modest increase in cell survival. To document alterations to sphingolipids in the CBF-silenced cells, ceramide, and lactosylceramide levels were directly examined by mass spectrometry. Substantial increases in ceramide species and decreases in lactosylceramides were identified. Altogether, this report provides evidence that CBF transcriptional pathways control cellular survival, at least in part, through sphingolipid metabolism. J. Cell. Physiol. 228: 2350-2364, 2013. (c) 2013 Wiley Periodicals, Inc. C1 [Greer, Adam H.; Fennell, Katie; Moustafa, Yara W.; Meyers, Shari] LSUHSC Sch Med Shreveport, Dept Biochem & Mol Biol, Shreveport, LA USA. [Greer, Adam H.; Yong, Thomas; Fennell, Katie; Moustafa, Yara W.; Galiano, Floyd; Cardelli, James; Meyers, Shari] LSUHSC Sch Med Shreveport, Feist Weiller Canc Ctr, Shreveport, LA USA. [Yong, Thomas] LSUHSC Sch Med Shreveport, Dept Med, Shreveport, LA USA. [Fowler, Marcie] US Army Inst Surg Res, JBSA Ft Sam, Houston, TX USA. [Ng, Shu-Wing; Berkowitz, Ross S.] Harvard Univ, Brigham & Womens Hosp, Dept Obstet & Gynecol, Div Gynecol Oncol,Lab Gynecol Oncol,Sch Med, Boston, MA 02115 USA. [Cardelli, James] LSUHSC Sch Med Shreveport, Dept Microbiol & Immunol, Shreveport, LA USA. [Davis, J. Nathan] Quinnipiac Univ, Frank H Netter MD Sch Med, Dept Med Sci, Hamden, CT 06518 USA. RP Davis, JN (reprint author), Quinnipiac Univ, Frank H Netter MD Sch Med, Dept Med Sci, 275 Mt Carmel Ave,MNH 307G, Hamden, CT 06518 USA. EM nathan.davis@quinnipiac.edu FU Feist-Weiller Cancer Center; U.S. Department of Defense [PC080196]; U.S. Army Institute of Surgical Research Battlefield Pain Control Task Area; U.S. Army Medical Research and Materiel Command [I_041_2011] FX Contract grant sponsor: Feist-Weiller Cancer Center.; Contract grant sponsor: U.S. Department of Defense;; Contract grant number: PC080196.; Contract grant sponsor: U.S. Army Institute of Surgical Research Battlefield Pain Control Task Area.; Contract grant sponsor: U.S. Army Medical Research and Materiel Command Combat Casualty and Clinical and Rehabilitative Medicine Research Programs;; Contract grant number: I_041_2011. NR 58 TC 2 Z9 2 U1 0 U2 10 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0021-9541 EI 1097-4652 J9 J CELL PHYSIOL JI J. Cell. Physiol. PD DEC PY 2013 VL 228 IS 12 BP 2350 EP 2364 DI 10.1002/jcp.24406 PG 15 WC Cell Biology; Physiology SC Cell Biology; Physiology GA 263IB UT WOS:000327800000012 PM 23813439 ER PT J AU Madson, AQ Tucker, D Aden, J Hale, RG Chan, RK AF Madson, Andrew Q. Tucker, David Aden, Jay Hale, Robert G. Chan, Rodney K. TI Non-battle craniomaxillofacial injuries from US military operations SO JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY LA English DT Article DE Craniomaxillofacial injury; Non-battle injury; Blunt trauma; MVC ID IRAQI-FREEDOM; ENDURING FREEDOM; MANDIBULAR FRACTURES; NONBATTLE INJURY; UNITED-STATES; COMBAT; AFGHANISTAN; CASUALTIES; TRAUMA; DISEASE AB Introduction: Non-battle injuries (NBIs) can be a source of significant resource utilization for the armed forces in a deployed setting. While the incidence and severity of craniomaxillofacial (CMF) battle injuries (BIs) have reportedly increased in the ongoing U.S. military conflicts in Iraq and Afghanistan, the prevalence and the nature of NBIs are not well described. Material and methods: The Joint Theater Trauma Registry was queried from October 2001 to February 2011, covering Operations Enduring Freedom and Iraqi Freedom, for both NBIs and BIs to the CMF region. Patient demographics, injury severity score, mechanism and type of injury were included in the query. Using ICD-9 diagnosis codes, CMF injuries were classified according to type (wounds, fractures, burns, vascular injuries, and nerve injuries). Statistical analysis was performed for comparative analysis. Results: NBIs constituted 24.3% of all patients with CMF injuries evacuated to a regional combat support hospital (CMF BIs 75.4%). These injuries were characterized by blunt trauma, most commonly motor vehicle collisions (37%), and falls (20%). As compared to CMF BIs, CMF NBIs resulted in less mortality (1.3% vs. 3.1%, p < 0.0001), fewer injuries per patient (1.87 vs. 2.26, p = 0.055), and a decreased severity score (ISS) (8.38 vs. 12.98, p < 0.0001). However, a significant percentage of CMF NBIs still required evacuation out of theater (27.8% of NBIs vs. 42.2% of BIs, p < 0.0001), depleting the combat strength of the deployed forces. Conclusions: CMF NBIs accounted for a substantial portion of total CMF injuries. Though characterized predominantly by blunt trauma with an overall better prognosis, its burden to the limited resources of a deployment can be significant. This descriptive study highlights the need to allocate appropriate resources for treatment of these injuries as well as strategies to reduce both its incidence and severity. Level of evidence: IV Prognostic (C) 2013 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved. C1 [Madson, Andrew Q.; Tucker, David; Aden, Jay; Hale, Robert G.; Chan, Rodney K.] US Army Inst Surg Res, Ft Sam Houston, TX USA. RP Chan, RK (reprint author), San Antonio Mil Med Ctr, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM amadson@gmail.com; david.tucker11@us.army.mil; james.aden@amedd.army.mil; robertg.hale@us.army.mil; rodney.k.chan@amedd.army.mil NR 25 TC 2 Z9 2 U1 0 U2 8 PU CHURCHILL LIVINGSTONE PI EDINBURGH PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE, LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND SN 1010-5182 EI 1878-4119 J9 J CRANIO MAXILL SURG JI J. Cranio-MaxilloFac. Surg. PD DEC PY 2013 VL 41 IS 8 BP 816 EP 820 DI 10.1016/j.jcms.2013.01.035 PG 5 WC Dentistry, Oral Surgery & Medicine; Surgery SC Dentistry, Oral Surgery & Medicine; Surgery GA 270HP UT WOS:000328309800020 PM 23561317 ER PT J AU Li, YZ Weber, NS Fisher, JA Yolken, RH Cowan, DN Larsen, RA Niebuhr, DW AF Li, Yuanzhang Weber, Natalya S. Fisher, Jared A. Yolken, Robert H. Cowan, David N. Larsen, Rakel A. Niebuhr, David W. TI Association between antibodies to multiple infectious and food antigens and new onset schizophrenia among US military personnel SO SCHIZOPHRENIA RESEARCH LA English DT Article DE Psychosis; Immune response; Sero-epidemiology; Case-control; Biomarker ID TOXOPLASMA-GONDII; AUTOIMMUNE-DISEASES; CEREBROSPINAL-FLUID; BIPOLAR DISORDER; HERPES-SIMPLEX; SERUM-LEVELS; T-CELLS; CYTOMEGALOVIRUS; PSYCHOSIS; INTERLEUKIN-6 AB Introduction: Multiple studies have documented immune activation in many individuals with schizophrenia suggesting that antigens capable of generating a prolonged immune response may be important environmental factors in many cases of this disorder. While existing studies have found single-agent associations of antibodies to food and neurotropic infectious agents with schizophrenia, a simultaneous examination of multiple agents may shed light on agent interactions or possible etiopathogenic pathways. Methods: We used traditional regression and novel statistical techniques to examine associations of single and combined infectious and food antigens with schizophrenia. We tested 6106 serum samples from 855 cases and 1165 matched controls. Results: Higher antibody levels to casein were borderline significant in the prediction of schizophrenia (HR = 1.08,p = 0.06). Study participants with higher cytomegalovirus (CMV) lgG antibody levels had a reduced risk of developing schizophrenia (HR = 0.90; p = 0.02). While lgG antibodies to gliadin, Toxoplasma gondii, vaccinia, measles, and human herpesvirus-6 (HHV-6) showed no significant independent associations with schizophrenia, the increase in antibody levels to several combinations of agents, to include casein, measles, CMV, T gondii and vaccinia, was predictive of an 18-34% increase in the risk of developing schizophrenia. Conclusion: Certain patterns of antibodies, involving some agents, were predictive of developing schizophrenia, with the magnitude of association rising when the level of antibodies increased to two or more agents. A heightened antibody response to a combination of several infectious food antigens might be an indicator of an altered immune response to antigenic stimuli. Published by Elsevier B.V. C1 [Li, Yuanzhang; Weber, Natalya S.; Fisher, Jared A.; Cowan, David N.; Larsen, Rakel A.; Niebuhr, David W.] Walter Reed Army Inst Res, Prevent Med Program, Silver Spring, MD 20910 USA. [Fisher, Jared A.; Cowan, David N.; Larsen, Rakel A.] Allied Technol Grp Inc, Rockville, MD 20850 USA. [Yolken, Robert H.] Johns Hopkins Univ, Sch Med, Dept Pediat, Stanley Div Dev Neurovirol, Baltimore, MD 21205 USA. [Niebuhr, David W.] Uniformed Serv Univ Hlth Sci, Div Epidemiol & Biostat, Dept Prevent Med & Biometr, Bethesda, MD 20814 USA. RP Weber, NS (reprint author), Walter Reed Army Inst Res, Prevent Med Program, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM Natalya.S.Weber.CIV@mail.mil OI Li, Yuanzhang/0000-0001-8872-4430 FU Stanley Medical Research Institute, Bethesda, Maryland [03-NV-005]; Department of the Army FX This work was supported by the Stanley Medical Research Institute, Bethesda, Maryland (Research Grant # 03-NV-005) and the Department of the Army. NR 68 TC 7 Z9 7 U1 1 U2 9 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0920-9964 EI 1573-2509 J9 SCHIZOPHR RES JI Schizophr. Res. PD DEC PY 2013 VL 151 IS 1-3 BP 36 EP 42 DI 10.1016/j.schres.2013.10.004 PG 7 WC Psychiatry SC Psychiatry GA 263GL UT WOS:000327795300005 PM 24139899 ER PT J AU King, DT Goatcher, BL Fischer, JW Stanton, J Lacour, JM Lemmons, SC Wang, GM AF King, D. Tommy Goatcher, Buddy L. Fischer, Justin W. Stanton, John Lacour, James M. Lemmons, Scott C. Wang, Guiming TI Home Ranges and Habitat Use of Brown Pelicans (Pelecanus occidentalis) in the Northern Gulf of Mexico SO WATERBIRDS LA English DT Article DE Brown Pelican; Brownian Bridge Movement Model; habitat use; home range; Louisiana; migration; Pelecanus occidentalis; satellite telemetry ID LOUISIANA; MOVEMENTS; CAPTURE AB Little is known about movements and habitat use of Brown Pelicans (Pelecanus occidentalis) in the northern Gulf of Mexico. We attached satellite transmitters to 18 adult Brown Pelicans (nine males, nine females) that were captured on Grand Isle along the Louisiana coast during 31 August-2 September 2010. Their movements and habitat use were tracked between September 2010 and March 2012. Nine of the Brown Pelicans remained proximate to the Louisiana coast; four ranged along the coasts of Alabama, Mississippi, and Louisiana; three moved from Louisiana to Texas; and two migrated across the Gulf of Mexico to the Yucatan Peninsula. Annual 99% home range estimates varied widely ((x) over bar = 10,611 km(2), SE = 2,370), and males had larger ranges ((x) over bar = 15,088 km(2), SE = 2,219) than females ((x) over bar = 6,133 km(2), SE = 1,764). Habitats used by Brown Pelicans were primarily open water, estuarine emergent wetland, grassland, unconsolidated shore, and deep water habitat types. C1 [King, D. Tommy; Lemmons, Scott C.] Wildlife Serv, USDA, Natl Wildlife Res Ctr, Mississippi State, MS 39762 USA. [Goatcher, Buddy L.] US Army Corps Engineers, Engineer Res & Dev Ctr, Environm Lab, Environm Risk Assessment Branch, Vicksburg, MS 39180 USA. [Fischer, Justin W.] Wildlife Serv, USDA, Natl Wildlife Res Ctr, Ft Collins, CO 80521 USA. [Stanton, John] US Fish & Wildlife Serv, US Dept Interior, South Atlantic Migratory Bird Coordinat Off, Columbia, NC USA. [Lacour, James M.] Louisiana Dept Wildlife & Fisheries, Baton Rouge, LA 70898 USA. [Wang, Guiming] Mississippi State Univ, Dept Wildlife Fisheries & Aquaculture, Mississippi State, MS 39762 USA. RP King, DT (reprint author), Wildlife Serv, USDA, Natl Wildlife Res Ctr, POB 6099, Mississippi State, MS 39762 USA. EM Tommy_King@aphis.usda.gov FU U.S. Department of Agriculture, Animal and Plant Health Inspection Service, Wildlife Services, National Wildlife Research Center; U.S. Fish and Wildlife Service, Office of Migratory Birds FX We thank the U.S. Department of Agriculture, Animal and Plant Health Inspection Service, Wildlife Services, National Wildlife Research Center, and the U.S. Fish and Wildlife Service, Office of Migratory Birds, for providing funding for this study. We thank the Louisiana Department of Wildlife and Fisheries for logistical support during pelican capture and D. Douglas for statistical support. We also thank F. Cunningham, M. Tobin and two anonymous reviewers for providing helpful comments on this manuscript. This research was conducted under U.S. Department of the Interior, Fish and Wildlife Service, Federal Fish and Wildlife Permit # MB19177A-0 and U.S. Department of the Interior, Fish and Wildlife Service, Office of Migratory Birds, ACUC review. NR 26 TC 0 Z9 1 U1 3 U2 23 PU WATERBIRD SOC PI WASHINGTON PA NATL MUSEUM NATURAL HISTORY SMITHSONIAN INST, WASHINGTON, DC 20560 USA SN 1524-4695 EI 1938-5390 J9 WATERBIRDS JI Waterbirds PD DEC PY 2013 VL 36 IS 4 BP 494 EP 500 PG 7 WC Ornithology SC Zoology GA 270DW UT WOS:000328300100011 ER PT J AU El Kadiri, H Barrett, CD Tschopp, MA AF El Kadiri, Haitham Barrett, Christopher D. Tschopp, Mark A. TI The candidacy of shuffle and shear during compound twinning in hexagonal close-packed structures SO ACTA MATERIALIA LA English DT Article DE Crystallography; Shear; Shuffle; Hexagonal; Twinning; Slip ID COMPUTER-SIMULATION; HCP METALS; DAMAGE NUCLEATION; MAGNESIUM ALLOYS; GRAIN-BOUNDARIES; ROOM-TEMPERATURE; DEFORMATION; CRYSTALS; CRYSTALLOGRAPHY; DISLOCATIONS AB This paper proposes a systematic generalized formulation for calculating both atomic shuffling and shear candidates for a given compound twinning mode in hexagonal closed-packed metals. Although shuffles play an important role in the mobility of twinning dislocations in non-symmorphic crystals, their analytical expressions have not been previously derived. The method is illustrated for both flat planes and corrugated planes which are exemplified by {1 1 (2) over bar 2} and {1 0 (1) over bar 2} twinning modes, respectively. The method distinguishes between shuffle displacements and net shuffles. While shuffle displacements correspond to movements between ideal atom positions in the parent and twin lattices, net shuffles comprise contributions from shear on overlying planes which can operate along opposite directions to those of shuffle displacements. Thus, net shuffles in the twinning direction can vanish in a limiting case, as is interestingly the case for those needed in the second plane by the b(4) dislocation candidate in {1 1 (2) over bar 2} twinning. It is found that while shuffle displacement vectors can be irrational when K-1 is corrugated, net shuffle vectors are always rational. (C) 2013 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved. C1 [El Kadiri, Haitham; Barrett, Christopher D.] Mississippi State Univ, Dept Mech Engn, Mississippi State, MS 39762 USA. [El Kadiri, Haitham; Barrett, Christopher D.; Tschopp, Mark A.] Mississippi State Univ, Ctr Adv Vehicular Syst, Mississippi State, MS 39759 USA. [Tschopp, Mark A.] Army Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. RP El Kadiri, H (reprint author), Mississippi State Univ, Dept Mech Engn, Mississippi State, MS 39762 USA. EM elkadiri@me.msstate.edu RI Tschopp, Mark/B-1594-2008 OI Tschopp, Mark/0000-0001-8471-5035 FU National Science Foundation under the DMREF (Designing Materials to Revolutionize and Engineer our Future) [CMMI-1235009]; US Army Research Laboratory (ARL) FX The authors would like to recognize the National Science Foundation which supported this work under the DMREF (Designing Materials to Revolutionize and Engineer our Future) program with the award number: CMMI-1235009. M.A.T. would like to acknowledge support from the US Army Research Laboratory (ARL) administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the US Department of Energy and ARL. NR 31 TC 5 Z9 5 U1 3 U2 33 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 1359-6454 EI 1873-2453 J9 ACTA MATER JI Acta Mater. PD DEC PY 2013 VL 61 IS 20 BP 7646 EP 7659 DI 10.1016/j.actamat.2013.09.002 PG 14 WC Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Materials Science; Metallurgy & Metallurgical Engineering GA 268OF UT WOS:000328179700012 ER PT J AU Karchevsky, AL Klibanov, MV Nguyen, L Pantong, N Sullivan, A AF Karchevsky, Andrey L. Klibanov, Michael V. Lam Nguyen Pantong, Natee Sullivan, Anders TI The Krein method and the globally convergent method for experimental data SO APPLIED NUMERICAL MATHEMATICS LA English DT Article DE 1-d Coefficient Inverse Problems; Comparison of two methods; Calibration factor ID INVERSE PROBLEM; EQUATION AB Comparison of numerical performances of two methods for coefficient inverse problems is described. The first one is the classical Krein integral equation method, and the second one is the recently developed approximately globally convergent numerical method. This comparison is performed for both computationally simulated and experimental data. (C) 2013 IMACS. Published by Elsevier B.V. All rights reserved. C1 [Karchevsky, Andrey L.] Sobolev Math Inst, Novosibirsk 630090, Russia. [Klibanov, Michael V.] Univ N Carolina, Dept Math & Stat, Charlotte, NC 28223 USA. [Lam Nguyen; Sullivan, Anders] US Army Res Lab, Adelphy, MD 20783 USA. [Pantong, Natee] Royal Thai Air Force Acad, Dept Math & Comp Sci, Bangkok, Thailand. RP Klibanov, MV (reprint author), Univ N Carolina, Dept Math & Stat, Charlotte, NC 28223 USA. EM karchevs@math.nsc.ru; mklibanv@uncc.edu; lam.h.nguyen2.civ@mail.mil; npantong@hotmail.com; anders.j.sullivan.civ@mail.mil OI Karchevsky, Andrey/0000-0003-1338-5723 FU US Army Research Laboratory; US Army Research Office [W911NF-11-1-0399]; Integration project of Siberian Branch of Russian Academy of Science (SB RAS) [14]; SB RAS; NAS of Ukraine [12]; Russian Foundation of Basic Research [12-01-00773] FX This research was supported by US Army Research Laboratory and US Army Research Office grant W911NF-11-1-0399, Integration project number 14 of Siberian Branch of Russian Academy of Science (SB RAS), Collaboration project number 12-2013 between SB RAS and NAS of Ukraine, and grant 12-01-00773 of Russian Foundation of Basic Research. NR 28 TC 6 Z9 6 U1 0 U2 2 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0168-9274 EI 1873-5460 J9 APPL NUMER MATH JI Appl. Numer. Math. PD DEC PY 2013 VL 74 BP 111 EP 127 DI 10.1016/j.apnum.2013.09.003 PG 17 WC Mathematics, Applied SC Mathematics GA 267LC UT WOS:000328098200008 ER PT J AU Moser, RD Allison, PG Chandler, MQ AF Moser, R. D. Allison, P. G. Chandler, M. Q. TI Characterization of Impact Damage in Ultra-High Performance Concrete Using Spatially Correlated Nanoindentation/SEM/EDX SO JOURNAL OF MATERIALS ENGINEERING AND PERFORMANCE LA English DT Article DE characterization; EDX; elastic moduli; high performance concrete; nanoindentation; SEM; ultra-high performance concrete ID C-S-H; ELASTIC-MODULUS; CEMENT; NANOCOMPOSITES; HARDNESS AB Little work has been done to study the fundamental material behaviors and failure mechanisms of cement-based materials including ordinary Portland cement concrete and ultra-high performance concretes (UHPCs) under high strain impact and penetration loads at lower length scales. These high strain rate loadings have many possible effects on UHPCs at the microscale and nanoscale, including alterations in the hydration state and bonding present in phases such as calcium silicate hydrate, in addition to fracture and debonding. In this work, the possible chemical and physical changes in UHPCs subjected to high strain rate impact and penetration loads were investigated using a novel technique wherein nanoindentation measurements were spatially correlated with images using scanning electron microscopy and chemical composition using energy dispersive x-ray microanalysis. Results indicate that impact degrades both the elastic modulus and indentation hardness of UHPCs, and in particular hydrated phases, with damage likely occurring due to microfracturing and debonding. C1 [Moser, R. D.; Allison, P. G.; Chandler, M. Q.] US Army Engineer Res & Dev Ctr, Geotechn & Structures Lab, Attn CEERD GM C, Vicksburg, MS 39180 USA. RP Moser, RD (reprint author), US Army Engineer Res & Dev Ctr, Geotechn & Structures Lab, Attn CEERD GM C, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM Robert.D.Moser@usace.army.mil; paul.g.allison@usace.army.mil OI Allison, Paul/0000-0002-9041-237X FU ERDC; U.S. Department of Defense SMART Scholarship Program FX The authors would like to thank Dr. Todd Rushing of the Geotechnical and Structures Laboratory, US Army Engineer Research and Development Center (ERDC), for supplying the specimens for this study. Financial support for this work was provided by the ERDC and the U.S. Department of Defense SMART Scholarship Program. Permission to publish was granted by the Director, ERDC Geotechnical and Structures Laboratory. NR 17 TC 6 Z9 6 U1 1 U2 19 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1059-9495 EI 1544-1024 J9 J MATER ENG PERFORM JI J. Mater. Eng. Perform. PD DEC PY 2013 VL 22 IS 12 BP 3902 EP 3908 DI 10.1007/s11665-013-0668-y PG 7 WC Materials Science, Multidisciplinary SC Materials Science GA 268YR UT WOS:000328207300039 ER PT J AU Bedair, SS Pulskamp, JS Polcawich, RG Morgan, B Martin, JL Power, B AF Bedair, Sarah S. Pulskamp, Jeffrey S. Polcawich, Ronald G. Morgan, Brian Martin, Joel L. Power, Brian TI Thin-Film Piezoelectric-on-Silicon Resonant Transformers SO JOURNAL OF MICROELECTROMECHANICAL SYSTEMS LA English DT Article DE Resonant transformers; thin-film piezoelectric transformers; PZT resonators; PZT-on-silicon resonators ID MEMS AB This paper reports the performance of lead-zirconate-titanate (PZT)-on-silicon electromechanical resonators as thin-film piezoelectric transformers. The PZT-on-silicon resonators rely on the odd harmonics of the contour length-extensional modes to provide a convenient means for voltage and current transformations with a single layer of piezoelectric PZT. The resistive-load-dependent voltage gains and efficiencies are derived along with the peak efficiencies and open circuit voltage gains. The models of efficiency and voltage gain are compared to the experimental measurements of fabricated PZT-on-silicon piezoelectric transformers with 2, 4, and 10 mu m of device silicon. The resonant frequencies of the devices range between 14 and 19 MHz. Peak efficiencies as high as 62% are measured and open circuit voltage gains as high as 5.7 are extracted from the measurements. The measured efficiencies with 50-Omega loads compare within 14% of the models on average (25% peak error). The extracted open-circuit voltage gains and their models compare within 22% on average (67% peak error). The trade between the load-dependent efficiencies and voltage gains are also presented for the n = 3, 5, 9, and 13 harmonics. C1 [Bedair, Sarah S.; Pulskamp, Jeffrey S.; Polcawich, Ronald G.; Morgan, Brian; Martin, Joel L.; Power, Brian] US Army Res Lab, Adelphi, MD 20783 USA. RP Bedair, SS (reprint author), US Army Res Lab, Adelphi, MD 20783 USA. EM sarah.s.bedair.civ@mail.mil; jeffrey.s.pulskamp.civ@mail.mil; Ronald.g.polcawich.civ@mail.mil; brian.c.morgan25.civ@mail.mil; joel.l.martin.civ@mail.mil; brian.k.power2.civ@mail.mil NR 33 TC 7 Z9 7 U1 1 U2 27 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1057-7157 EI 1941-0158 J9 J MICROELECTROMECH S JI J. Microelectromech. Syst. PD DEC PY 2013 VL 22 IS 6 BP 1383 EP 1394 DI 10.1109/JMEMS.2013.2262585 PG 12 WC Engineering, Electrical & Electronic; Nanoscience & Nanotechnology; Instruments & Instrumentation; Physics, Applied SC Engineering; Science & Technology - Other Topics; Instruments & Instrumentation; Physics GA 266TT UT WOS:000328047300016 ER PT J AU Starkweather, AR Pair, VE AF Starkweather, Angela R. Pair, Vincent E. TI Decoding the Role of Epigenetics and Genomics in Pain Management SO PAIN MANAGEMENT NURSING LA English DT Review ID MU-OPIOID RECEPTOR; NEUROPATHIC PAIN; INFLAMMATORY PAIN; DOWN-REGULATION; GENE; MODULATION; MORPHINE; MODEL; SCN9A; SENSITIZATION AB Persistent pain is a costly epidemic, affecting > 50 million Americans with estimated expenditures of > $200 billion annually for direct care and lost productivity. Recent advances in epigenetic/genomic understanding of pain and analgesic response may lead to improvements in pain management and help curtail costs by providing more precise detection of the pain mechanisms involved and thereby more personalized and effective treatments. However, the translation of epigenetic and genomic strategies for pain management into clinical practice will depend on understanding their potential applications. The purpose of this article is to examine current knowledge about epigenetic and genomic mechanisms of persistent pain and potential opportunities for improving pain management. The initial discussion focuses on present understanding of nociceptive pathways and alterations that lead to pathologic pain. The discussion then moves to a review of epigenetic mechanisms that have been identified in the transition to and maintenance of persistent pain as well as in the individual's response to analgesics. Potential applications of epigenetics/genomics to identify people at risk and possibly prevent persistent pain and guide diagnosis and the selection of therapeutic modalities are presented. (C) 2013 by the American Society for Pain Management Nursing C1 Virginia Commonwealth Univ, Sch Nursing, Dept Adult Hlth & Nursing Syst, Richmond, VA 23112 USA. US Army Reserve, Off Surg, Atlanta, GA USA. RP Starkweather, AR (reprint author), Virginia Commonwealth Univ, Sch Nursing, 1100 East Leigh St,POB 980567, Richmond, VA 23112 USA. EM astarkweathe@vcu.edu NR 56 TC 0 Z9 0 U1 1 U2 9 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1524-9042 EI 1532-8635 J9 PAIN MANAG NURS JI Pain Manag. Nurs. PD DEC PY 2013 VL 14 IS 4 BP 358 EP 367 DI 10.1016/j.pmn.2011.05.006 PG 10 WC Nursing SC Nursing GA 269QD UT WOS:000328256100047 PM 24315259 ER PT J AU Yingst, SL Opaschaitat, P Kanitpun, R Thammasart, S Ekgatat, M Jirathanawat, V Wongwicharn, P AF Yingst, Samuel L. Opaschaitat, Pattarin Kanitpun, Reka Thammasart, Suree Ekgatat, Monaya Jirathanawat, Vimol Wongwicharn, Preecha TI Q Fever Surveillance in Ruminants, Thailand, 2012 SO EMERGING INFECTIOUS DISEASES LA English DT Letter ID COXIELLA-BURNETII INFECTION; PERFORMANCE; ABORTION; SHEEP C1 [Yingst, Samuel L.] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Opaschaitat, Pattarin; Kanitpun, Reka; Thammasart, Suree; Ekgatat, Monaya; Wongwicharn, Preecha] Natl Inst Anim Hlth, Bangkok, Thailand. [Jirathanawat, Vimol] Reg 8 Reg Vet Diagnost Ctr, Surat Thani, Thailand. RP Yingst, SL (reprint author), Armed Forces Res Inst Med Sci, US Army Mat Command, APO AP 96546, Bangkok 10400, Thailand. EM samuel.yingst@afrims.org NR 10 TC 1 Z9 2 U1 0 U2 13 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 1080-6040 EI 1080-6059 J9 EMERG INFECT DIS JI Emerg. Infect. Dis PD DEC PY 2013 VL 19 IS 12 BP 2056 EP 2058 DI 10.3201/eid1912.130624 PG 3 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 263RV UT WOS:000327826600036 PM 24274364 ER PT J AU Kraemer, WJ Flanagan, SD Volek, JS Nindl, BC Vingren, JL Dunn-Lewis, C Comstock, BA Hooper, DR Szivak, TK Looney, DP Maresh, CM Hymer, WC AF Kraemer, William J. Flanagan, Shawn D. Volek, Jeff S. Nindl, Bradley C. Vingren, Jakob L. Dunn-Lewis, Courtenay Comstock, Brett A. Hooper, David R. Szivak, Tunde K. Looney, David P. Maresh, Carl M. Hymer, Wesley C. TI Resistance exercise induces region-specific adaptations in anterior pituitary gland structure and function in rats SO JOURNAL OF APPLIED PHYSIOLOGY LA English DT Article DE resistance training; 22-kD growth hormone; somatotrophs; adaptation ID FLOW CYTOMETRIC ANALYSIS; GROWTH-HORMONE; RESPONSE PATTERNS; PROLACTIN CELLS; II SOMATOTROPHS; FEMALE RATS; MEN; STRENGTH; WOMEN; HETEROGENEITY AB The anterior pituitary gland (AP) increases growth hormone (GH) secretion in response to resistance exercise (RE), but the nature of AP adaptations to RE is unknown. To that end, we examined the effects of RE on regional AP somatotroph GH release, structure, and relative quantity. Thirty-six Sprague-Dawley rats were assigned to one of four groups: 1) no training or acute exercise (NT-NEX); 2) no training with acute exercise (NT-EX); 3) resistance training without acute exercise (RT-NEX); 4) resistance training with acute exercise (RT-EX). RE incorporated 10, 1 m-weighted ladder climbs at an 85 degrees angle. RT groups trained 3 days/wk for 7 wk, progressively. After death, trunk blood was collected, and each AP was divided into quadrants (ventral-dorsal and left-right). We measured: 1) trunk plasma GH; 2) somatotroph GH release; 3) somatotroph size; 4) somatotroph secretory content; and 5) percent of AP cells identified as somatotrophs. Trunk GH differed by group (NT-NEX, 8.9 +/- 2.4 +/- mu g/l; RT-NEX, 9.2 +/- 3.5 mu g/l; NT-EX, 15.6 +/- 3.4 mu g/l; RT-EX, 23.4 +/- 4.6 mu g/l). RT-EX demonstrated greater somatotroph GH release than all other groups, predominantly in ventral regions (P < 0.05-0.10). Ventral somatotrophs were larger in NT-EX and RT-NEX compared with RT-EX (P < 0.05-0.10). RT-NEX exhibited significantly greater secretory granule content than all other groups but in the ventral-right region only (P < 0.05-0.10). Our findings indicate reproducible patterns of spatially distinct, functionally different somatotroph subpopulations in the rat pituitary gland. RE training appears to induce dynamic adaptations in somatotroph structure and function. C1 [Kraemer, William J.; Flanagan, Shawn D.; Volek, Jeff S.; Dunn-Lewis, Courtenay; Comstock, Brett A.; Hooper, David R.; Szivak, Tunde K.; Looney, David P.; Maresh, Carl M.] Univ Connecticut, Human Performance Lab, Dept Kinesiol, Storrs, CT 06269 USA. [Kraemer, William J.] Univ Connecticut, Dept Physiol & Neurobiol, Storrs, CT 06269 USA. [Vingren, Jakob L.] Univ N Texas, Dept Kinesiol Hlth Promot & Recreat, Appl Physiol Labs, Denton, TX 76203 USA. [Nindl, Bradley C.] Army Inst Publ Hlth, US Army Publ Hlth Command, Aberdeen Proving Ground, MD USA. [Hymer, Wesley C.] Penn State Univ, Dept Biochem & Mol Biol, University Pk, PA 16802 USA. RP Kraemer, WJ (reprint author), Univ Connecticut, Human Performance Lab, Dept Kinesiol, 2095 Hillside Rd,Unit 1110, Storrs, CT 06269 USA. EM william.kraemer@uconn.edu OI Dunn-Lewis, Courtenay/0000-0002-2406-4215 NR 45 TC 4 Z9 4 U1 0 U2 6 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 8750-7587 EI 1522-1601 J9 J APPL PHYSIOL JI J. Appl. Physiol. PD DEC PY 2013 VL 115 IS 11 BP 1641 EP 1647 DI 10.1152/japplphysiol.00687.2013 PG 7 WC Physiology; Sport Sciences SC Physiology; Sport Sciences GA 263YS UT WOS:000327844500008 PM 24092688 ER PT J AU Wilk, JE West, JC Duffy, FF Herrell, RK Rae, DS Hoge, CW AF Wilk, Joshua E. West, Joyce C. Duffy, Farifteh F. Herrell, Richard K. Rae, Donald S. Hoge, Charles W. TI Use of Evidence-Based Treatment for Posttraumatic Stress Disorder in Army Behavioral Healthcare SO PSYCHIATRY-INTERPERSONAL AND BIOLOGICAL PROCESSES LA English DT Article ID COGNITIVE PROCESSING THERAPY; PRACTICE PATTERNS; VICTIMS; PROFESSIONALS; ATTITUDES; INTERNET AB Objective: To identify the extent to which evidence-based psychotherapy (EBP) and psychopharmacologic treatments for posttraumatic stress disorder (PTSD) are provided to U. S. service members in routine practice, and the degree to which they are consistent with evidence-based treatment guidelines. Method: We surveyed the majority of Army behavioral health providers (n = 2,310); surveys were obtained from 543 (26%). These clinicians reported clinical data on a total sample of 399 service member patients. Of these patients, 110 (28%) had a reported PTSD diagnosis. Data were weighted to account for sampling design and non-responses. Results: Army providers reported 86% of patients with PTSD received evidence-based psychotherapy (EBP) for PTSD. As formal training hours in EBPs increased, reported use of EBPs significantly increased. Although EBPs for PTSD were reported to be widely used, clinicians who deliver EBP frequently reported not adhering to all core procedures recommended in treatment manuals; less than half reported using all the manualized core EBP techniques. Conclusions: Further research is necessary to understand why clinicians modify EBP treatments, and what impact this has on treatment outcomes. More data regarding the implications for treatment effectiveness and the role of clinical context, patient preferences, and clinical decision-making in adapting EBPs could help inform training efforts and the ways that these treatments may be better adapted for the military. C1 [Wilk, Joshua E.; Herrell, Richard K.; Hoge, Charles W.] US Army Med Res & Mat Command, Ctr Mil Psychiat & Neurosci, Dept Mil Psychiat, Walter Reed Army Inst Res, Silver Spring, MD USA. [West, Joyce C.; Duffy, Farifteh F.; Rae, Donald S.] Amer Psychiat Fdn, Amer Psychiat Inst Res & Educ, Arlington, VA USA. RP Wilk, JE (reprint author), Walter Reed Army Inst Res, Dept Mil Psychiat, Ctr Mil Psychiat & Neurosci, Silver Spring, MD 20910 USA. EM joshua.e.wilk.civ@mail.mil FU Military Operational Medicine Research Area Directorate, U.S. Army Medical Research and Materiel Command, Ft. Detrick, Maryland; U.S. Army behavioral health providers; Army Office of the Surgeon General FX Material has been reviewed by the Walter Reed Army Institute of Research. There is no objection to its presentation and/or publication. The opinions or assertions contained herein are the private views of the authors, and are not to be construed as official, or as reflecting true views of the Department of the Army or the Department of Defense. Funding for this project came from the Military Operational Medicine Research Area Directorate, U.S. Army Medical Research and Materiel Command, Ft. Detrick, Maryland.; The authors thank the U.S. Army behavioral health providers and the Army Office of the Surgeon General for their support and participation in this study and for their service to our nation. We thank the Mountain West Research Center for their work in developing the on-line survey. NR 19 TC 9 Z9 9 U1 1 U2 7 PU GUILFORD PUBLICATIONS INC PI NEW YORK PA 72 SPRING STREET, NEW YORK, NY 10012 USA SN 0033-2747 J9 PSYCHIATRY JI Psychiatry-Interpers. Biol. Process. PD WIN PY 2013 VL 76 IS 4 BP 336 EP 348 PG 13 WC Psychiatry SC Psychiatry GA 263ND UT WOS:000327814400003 PM 24299092 ER PT J AU Rheinhardt, R Wilder, T Williams, H Klimas, C Noble, C AF Rheinhardt, Richard Wilder, Timothy Williams, Hans Klimas, Charles Noble, Chris TI Variation in Forest Canopy Composition of Riparian Networks from Headwaters to Large River Floodplains in the Southeast Coastal Plain, USA SO WETLANDS LA English DT Article DE Canopy composition; Coastal Plain; Hydrogeomorphology; Riverine wetlands; Wetland management ID FOLIAGE STRUCTURE; WETLANDS; BIRDS; LOUISIANA; STREAMS; SWAMPS; CARBON AB Data on canopy trees (stems a parts per thousand yen 15 cm DBH) in riparian wetlands, spanning from headwaters to large river floodplains, were used to test whether forest canopy composition differed among hydrogeomorphic (HGM) riverine subclasses and among physiographic sub-regions (Major Land Resource Areas; MLRA) within a given HGM subclass. Riverine stands (n = 225) were sampled in four MLRA regions of the Southeastern U.S. Atlantic and Gulf Coastal Plain Physiographic Provinces. Composition data were analyzed using Non-metric Multidimensional Scaling and Multiple-Response Permutation Procedures to evaluate differences among HGM subclasses and MLRA regions. Analyses showed that canopy composition differed among three a priori subclasses related to Strahler stream order: headwater complex (along 1st-3rd order streams), mid-gradient floodplain (4th-6th order), and low-gradient floodplain (> 6th order). Further, composition also differed by MLRA region within each subclass. Thus, not only was species composition related to riverine hydrogeomorphology across a wide physiographic area, but differences in composition within HGM subclasses were also related to sub-region. These data could be useful in defining floristic reference standards when evaluating floodplain condition in southeastern USA Coastal Plain stream networks. C1 [Rheinhardt, Richard] E Carolina Univ, Dept Biol, Greenville, NC 27858 USA. [Wilder, Timothy; Klimas, Charles; Noble, Chris] US Army, Corps Engineers, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. [Williams, Hans] Stephen F Austin State Univ, Arthur Temple Coll Forestry & Agr, Nacogdoches, TX 75962 USA. RP Rheinhardt, R (reprint author), E Carolina Univ, Dept Biol, Greenville, NC 27858 USA. EM rheinhardtr@ecu.edu; Timothy.C.Wilder@erdc.dren.mil; hwilliams@sfasu.edu; cvklimas@att.net; Chris.V.Noble@usace.army.mil FU U. S. Army Corps of Engineers, Engineer Research and Development Center (ERDC) FX Funding was provided by the U. S. Army Corps of Engineers, Engineer Research and Development Center (ERDC). Field data were collected by many individuals besides the authors, Elizabeth Murray in Arkansas, Jill Clancy in Alabama, Keith Daily, Darinda Dans, Levi Gibson, Penny Gibson, Rachael McNamee Erwin, and Adam Miller in Texas and Louisiana. Identification of data to be collected and methods of collection were jointly decided upon by the authors and a panel of wetland experts, including Mark Brinson (East Carolina University), Tom Roberts (Tennessee Technological University), Tad Zebryk (U. S. Corps of Engineers-Mobile District), Richard Darden (U. S. Corps of Engineers Charleston District), Les Parker (U. S. Corps of Engineers-Charleston District), Mike Zeman (U. S. Natural Resources Conservation Service Tennessee), Bill Ainslie (U. S. Environmental Protection Agency-Atlanta), Dave Lekson (U. S. Corps of Engineers-Wilmington District), and Justin Hammonds (U. S. Corps of Engineers-Savannah District). Thanks are also extended to two anonymous reviewers who helped improve the manuscript. NR 50 TC 1 Z9 2 U1 1 U2 12 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0277-5212 EI 1943-6246 J9 WETLANDS JI Wetlands PD DEC PY 2013 VL 33 IS 6 BP 1117 EP 1126 DI 10.1007/s13157-013-0467-0 PG 10 WC Ecology; Environmental Sciences SC Environmental Sciences & Ecology GA 257LV UT WOS:000327386800012 ER PT J AU Heiner, JD Bebarta, VS Varney, SM Bothwell, JD Cronin, AJ AF Heiner, Jason D. Bebarta, Vikhyat S. Varney, Shawn M. Bothwell, Jason D. Cronin, Aaron J. TI Clinical Effects and Antivenom Use for Snake Bite Victims Treated at Three US Hospitals in Afghanistan SO WILDERNESS & ENVIRONMENTAL MEDICINE LA English DT Article; Proceedings Paper CT Research Forum of the American-College-of-Emergency-Physicians (ACEP) CY OCT 08-09, 2012 CL Denver, CO SP Amer Coll Emergency Phys DE snake envenomation; snake antivenom; Afghanistan AB Objective.-Annually, more than 100,000 US and international military and civilian personnel work in Afghanistan within terrain harboring venomous snakes. Current literature insufficiently supports Afghan antivenom treatment and stocking guidelines. We report the clinical course and treatments for snakebite victims presenting to US military hospitals in Afghanistan. Methods.-All snakebite victims presenting to 3 US military emergency departments between July 2010 and August 2011 in northern and southern Afghanistan were examined via chart review. Case information included patient demographics, snake description, bite details and complications, laboratory results, antivenom use and adverse effects, procedures performed, and hospital course. Results.-Of 17 cases, median patient age was 20 years (interquartile range [IQR], 12-30), 16 were male, and 82% were Afghans. All bites were to an extremity, and median time to care was 2.8 hours (IQR, 2-5.8). On arrival, 8 had tachycardia and none had hypotension or hypoxia. A viper was implicated in 5 cases. Ten cases received at least 1 dose of polyvalent antivenom, most commonly for coagulopathy, without adverse effects. Six received additional antivenom, 6 had an international normalized ratio (INR) > 10, and none developed delayed coagulopathy. Three received blood transfusions. Hospital stay ranged from 1 to 4 days. None required vasopressors, fasciotomy, or other surgery, and none died. All had resolution of marked coagulopathies and improved swelling and pain on discharge. Conclusions.-We report the largest series of snake envenomations treated by US physicians in Afghanistan. Antivenom was tolerated well with improvement of coagulopathy and symptoms. All patients survived with minimal advanced interventions other than blood transfusion. C1 [Heiner, Jason D.] Univ Washington, Seattle, WA 98195 USA. [Heiner, Jason D.; Bebarta, Vikhyat S.; Varney, Shawn M.] San Antonio Mil Med Ctr, Ft Sam Houston, TX USA. [Cronin, Aaron J.] Womack Army Med Ctr, Ft Bragg, NC USA. RP Heiner, JD (reprint author), Univ Washington, Med Ctr, Div Emergency Med, 1959 NE Pacific St,Box 356123, Seattle, WA 98195 USA. EM jheiner@uw.edu RI bebarta, vikhyat/K-3476-2015 NR 9 TC 3 Z9 3 U1 1 U2 6 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1080-6032 EI 1545-1534 J9 WILD ENVIRON MED JI Wildern. Environ. Med. PD WIN PY 2013 VL 24 IS 4 BP 412 EP 416 PG 5 WC Public, Environmental & Occupational Health; Sport Sciences SC Public, Environmental & Occupational Health; Sport Sciences GA 266HO UT WOS:000328014900017 PM 23870762 ER PT J AU Waddell, SR AF Waddell, Steve R. TI Turning the Tide: How a Small Band of Allied Sailors Defeated the U-Boats and Won the Battle of the Atlantic. SO HISTORIAN LA English DT Book Review C1 [Waddell, Steve R.] US Mil Acad, West Point, NY 10996 USA. RP Waddell, SR (reprint author), US Mil Acad, West Point, NY 10996 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0018-2370 EI 1540-6563 J9 HISTORIAN JI Historian PD DEC PY 2013 VL 75 IS 4 BP 921 EP 922 DI 10.1111/hisn.12023_74 PG 2 WC History SC History GA 256IG UT WOS:000327302400078 ER PT J AU Fletes, F Daula, J Kwak, EG AF Fletes, Francisco Daula, John Kwak, Elizabeth Guinto TI Dialectical behavior therapy in bipolar disorder: clinical applications in outpatient population at Tripler Army Medical Center- a proposed treatment SO INTERNATIONAL JOURNAL OF PSYCHIATRY IN CLINICAL PRACTICE LA English DT Meeting Abstract C1 [Fletes, Francisco; Daula, John; Kwak, Elizabeth Guinto] Tripler Army Med Ctr, Honolulu, HI 96859 USA. NR 0 TC 0 Z9 0 U1 3 U2 6 PU INFORMA HEALTHCARE PI LONDON PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND SN 1365-1501 EI 1471-1788 J9 INT J PSYCHIAT CLIN JI Int. J. Psychiat. Clin. PD DEC PY 2013 VL 17 SU 2 BP 20 EP 20 PG 1 WC Psychiatry SC Psychiatry GA 258NI UT WOS:000327465600049 ER PT J AU Chen, XYK Walters, TJ AF Chen, Xiaoyu K. Walters, Thomas J. TI Muscle-derived decellularised extracellular matrix improves functional recovery in a rat latissimus dorsi muscle defect model SO JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY LA English DT Article DE Craniofacial maxillary injuries; Muscle function; Skeletal muscle; Volumetric muscle loss ID MURINE MODEL; IN-VIVO; INDUCTIVE SCAFFOLD; REPAIR CONSTRUCT; ACELLULAR MATRIX; TISSUE; REGENERATION; DEGRADATION; INJURY; REPLACEMENT AB Purpose: Craniofacial maxillary injuries represent nearly 30% of all battlefield wounds, often involving volumetric muscle loss (VML). The physical loss of muscle results in functional deficits and cosmetic disfigurement. Although surgical solutions are limited, advances in biomaterials offer great promise for the restoration of form and function following VML. The primary purpose of this study was to determine whether muscle function could be restored in a novel VML rat model using muscle-derived extracellular matrix (M-ECM). Methods: Ten percent of the mass of the latissimus dorsi (LD) was excised. Three groups were examined: 1) no repair of defect (DEF), 2) repair with M-ECM and 3) sham (all procedures except muscle excision). Four and 8 weeks post-surgery, the isometric contractile properties of the LD were assessed in situ and selected histological properties were evaluated. Results: The defect resulted in an initial reduction in peak isometric force (Po) of 30%. At 8 weeks the difference between DEF and sham was 20.5%. At the same time, M-ECM was only 8.4% below sham. Although the histological analysis revealed a narrow, but well-formed band of muscle running along the middle of the M-ECM, it was judged to be too small to account for the observed improvement in muscle force. Conclusions: Repair of VML with M-ECM can dramatically improve muscle function independent of muscle regeneration by providing a physical bridge that accommodates force transmission across the injury site. This method of repair may provide an easily translatable surgical method for selected forms of VML. Published by Elsevier Ltd on behalf of British Association of Plastic, Reconstructive and Aesthetic Surgeons. C1 [Chen, Xiaoyu K.; Walters, Thomas J.] US Army Inst Surg Res, Extrem Trauma & Regenerat Med Res Program, San Antonio, TX 78676 USA. [Chen, Xiaoyu K.] Wake Forest Inst Regenerat Med, Winston Salem, NC USA. RP Walters, TJ (reprint author), US Army Inst Surg Res, San Antonio, TX 78676 USA. EM thomas.walters@us.army.mil FU Armed Forces Institute of Regenerative Medicine; U.S. Army Medical Research and Medical Command [W81XWH-09-2-0177]; Orthopaedic Trauma Research Program [W81XWH-09-2-0177] FX X. C. was supported through a postdoctoral fellowship from the Armed Forces Institute of Regenerative Medicine, administered through Wake Forest Institute of Regenerative Medicine, Winston-Salem, NC, USA. This study was supported by the U.S. Army Medical Research and Medical Command (grant W81XWH-09-2-0177) and the Orthopaedic Trauma Research Program (grant W81XWH-09-2-0177) of the Department of Defense. The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the Department of the Army or the Department of Defense (AR 360-5) or United States government. The authors are employees of the U. S. government and this work was prepared as part of their official duties. This study has been conducted in compliance with the Animal Welfare Act, the Implementing Animal Welfare Regulations and in accordance with the principles of the Guide for the Care and Use of Laboratory Animals. All animal procedures were approved by the United States Army Institute of Surgical Research Animal Care and Use Committee. NR 29 TC 17 Z9 17 U1 0 U2 6 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1748-6815 EI 1878-0539 J9 J PLAST RECONSTR AES JI J. Plast. Reconstr. Aesthet. Surg. PD DEC PY 2013 VL 66 IS 12 BP 1750 EP 1758 DI 10.1016/j.bjps.2013.07.037 PG 9 WC Surgery SC Surgery GA 259MY UT WOS:000327532200030 PM 24007646 ER PT J AU Kijak, GH Tovanabutra, S Rerks-Ngarm, S Nitayaphan, S Eamsila, C Kunasol, P Khamboonruang, C Thongcharoen, P Namwat, C Premsri, N Benenson, M Morgan, P Bose, M Sanders-Buell, E Paris, R Robb, ML Birx, DL De Souza, MS McCutchan, FE Michael, NL Kim, JH AF Kijak, Gustavo H. Tovanabutra, Sodsai Rerks-Ngarm, Supachai Nitayaphan, Sorachai Eamsila, Chirapa Kunasol, Prayura Khamboonruang, Chirasak Thongcharoen, Prasert Namwat, Chawetsan Premsri, Nakorn Benenson, Michael Morgan, Patricia Bose, Meera Sanders-Buell, Eric Paris, Robert Robb, Merlin L. Birx, Deborah L. De Souza, Mark S. McCutchan, Francine E. Michael, Nelson L. Kim, Jerome H. TI Molecular Evolution of the HIV-1 Thai Epidemic between the Time of RV144 Immunogen Selection to the Execution of the Vaccine Efficacy Trial (vol 87, pg 7265, 2013) SO JOURNAL OF VIROLOGY LA English DT Correction C1 [Kijak, Gustavo H.] Henry M Jackson Fdn Adv Mil Med, US Mil HIV Res Program, Bethesda, MD USA. Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD USA. Minist Publ Hlth, Dept Dis Control, Nonthaburi, Thailand. Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. RP Kijak, GH (reprint author), Henry M Jackson Fdn Adv Mil Med, US Mil HIV Res Program, Bethesda, MD USA. NR 1 TC 1 Z9 1 U1 0 U2 2 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0022-538X EI 1098-5514 J9 J VIROL JI J. Virol. PD DEC PY 2013 VL 87 IS 23 BP 13084 EP 13084 DI 10.1128/JVI.02624-13 PG 1 WC Virology SC Virology GA 254RG UT WOS:000327183800059 ER PT J AU Cai, YY Yu, SQ Mazur, S Dong, L Janosko, K Zhang, TF Muller, MA Hensley, LE Bavari, S Jahrling, PB Radoshitzky, SR Kuhn, JH AF Cai, Yingyun Yu, Shuiqing Mazur, Steven Dong, Lian Janosko, Krisztina Zhang, Tengfei Mueller, Marcel A. Hensley, Lisa E. Bavari, Sina Jahrling, Peter B. Radoshitzky, Sheli R. Kuhn, Jens H. TI Nonhuman Transferrin Receptor 1 Is an Efficient Cell Entry Receptor for Ocozocoautla de Espinosa Virus SO JOURNAL OF VIROLOGY LA English DT Article ID HEMORRHAGIC-FEVER ARENAVIRUSES; LYMPHOCYTIC CHORIOMENINGITIS VIRUS; JUNIN VIRUS; GLYCOPROTEINS; INFECTION; MEXICO; MICE AB Ocozocoautla de Espinosa virus (OCEV) is a novel, uncultured arenavirus. We found that the OCEV glycoprotein mediates entry into grivet and bat cells through transferrin receptor 1 (TfR1) binding but that OCEV glycoprotein precursor (GPC)-pseudotyped retroviruses poorly entered 53 human cancer cell lines. Interestingly, OCEV and Tacaribe virus could use bat, but not human, TfR1. Replacing three human TfR1 amino acids with their bat ortholog counterparts transformed human TfR1 into an efficient OCEV and Tacaribe virus receptor. C1 [Cai, Yingyun; Yu, Shuiqing; Mazur, Steven; Janosko, Krisztina; Zhang, Tengfei; Hensley, Lisa E.; Jahrling, Peter B.; Kuhn, Jens H.] NIAID, Integrated Res Facil Ft Detrick, NIH, Frederick, MD USA. [Dong, Lian; Bavari, Sina; Radoshitzky, Sheli R.] US Army Med Res Inst Infect Dis, Frederick, MD USA. [Mueller, Marcel A.] Univ Bonn, Inst Virol, Med Ctr, Bonn, Germany. RP Kuhn, JH (reprint author), NIAID, Integrated Res Facil Ft Detrick, NIH, Frederick, MD USA. EM sheli.r.radoshitzky.ctr@mail.mil; kuhnjens@mail.nih.gov RI Kuhn, Jens H./B-7615-2011; OI Kuhn, Jens H./0000-0002-7800-6045; Mueller, Marcel/0000-0003-2242-5117 FU NIAID [HHSN272200700016I]; Joint Science and Technology Office for Chemical and Biological Defense [TMTI0048_09_RD_T] FX Y.C. and J.H.K. performed this work as employees of Tunnell Consulting, Inc., S. M. as an employee of MRI Global, T.Z. as an employee of Lovelace, and S.Y. and K.J. as employees of Battelle Memorial Institute, all under Battelle's prime contract with NIAID under contract number HHSN272200700016I. This work was in part funded by the Joint Science and Technology Office for Chemical and Biological Defense (proposal number TMTI0048_09_RD_T to S.B.). NR 27 TC 3 Z9 3 U1 1 U2 9 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0022-538X EI 1098-5514 J9 J VIROL JI J. Virol. PD DEC PY 2013 VL 87 IS 24 BP 13930 EP 13935 DI 10.1128/JVI.02701-13 PG 6 WC Virology SC Virology GA 258EZ UT WOS:000327443300081 PM 24109228 ER PT J AU Saluja, S Brietzke, SE Egan, KK Klavon, S Robson, CD Waltzman, ML Roberson, DW AF Saluja, Saurabh Brietzke, Scott E. Egan, Kristin K. Klavon, Susan Robson, Caroline D. Waltzman, Mark L. Roberson, David W. TI A Prospective Study of 113 Deep Neck Infections Managed Using a Clinical Practice Guideline SO LARYNGOSCOPE LA English DT Article DE Pediatric infectious; inflammatory; retropharyngeal abscess; prospective study; clinical practice guideline; cost analysis ID RESISTANT STAPHYLOCOCCUS-AUREUS; RETROPHARYNGEAL ABSCESS; SPACE INFECTIONS; MEDIASTINITIS; TOMOGRAPHY; CHILDREN AB Objectives/HypothesisRetropharyngeal abscesses are a difficult to diagnose condition in children. Though some children with such abscesses can be managed with intravenous (IV) antibiotics alone, our group has argued that surgical drainage is the gold standard for safe management and likely leads to shorter hospital stays. We present prospective data on children with retropharyngeal infections who were managed according to a clinical practice guideline that emphasizes reliance on computed tomography and prompt surgical drainage when pus is felt to be present. Study DesignProspective observational study at a tertiary care children's hospital. MethodsChildren were included in the study if a retropharyngeal infection was suspected and they were treated according to the clinical guideline between July 2001 and March 2004. ResultsOf 111 children in the study, 73 were ultimately treated with incision and drainage. There was no long-term morbidity or mortality. Surgical patients were more likely to require an intensive care unit (ICU) admission than patients managed with IV antibiotics alone (26.0% vs. 5.3%, P<.01) and on average cost nearly $8,000 more ($22,071 and $14,950; P<.01). However, these results may be biased, as patients requiring surgery were younger, which likely influenced the decision for ICU admission. ConclusionsIt is possible to treat pediatric retropharyngeal infections according to our clinical guideline with nearly zero long-term morbidity and mortality. Our data showed good outcomes for both groups, and substantially higher costs for patients treated surgically. These results cannot be regarded as definitive, because surgery was consistently advised for all patients with suspected pus, and because the surgical group was younger than the nonsurgical group. Level of Evidence2c. Laryngoscope, 123:3211-3218, 2013 C1 [Saluja, Saurabh] Weill Cornell Med Ctr, Dept Surg, New York, NY USA. Harvard Univ, Boston, MA 02115 USA. [Brietzke, Scott E.] Walter Reed Army Med Ctr, Dept Otolaryngol, Washington, DC 20307 USA. [Egan, Kristin K.] Otolaryngol Private Practice, Manhattan Beach, CA USA. [Robson, Caroline D.] Childrens Hosp Boston, Dept Radiol, Boston, MA 02115 USA. [Waltzman, Mark L.] Childrens Hosp Boston, Div Emergency Med, Boston, MA 02115 USA. [Roberson, David W.] Childrens Hosp Boston, Dept Otolaryngol, Boston, MA 02115 USA. RP Roberson, DW (reprint author), Childrens Hosp Boston, Dept Otolaryngol, 300 Longwood Ave, Boston, MA 02115 USA. EM david.roberson@childrens.harvard.edu OI Robson, Caroline/0000-0001-5592-249X NR 14 TC 3 Z9 3 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0023-852X EI 1531-4995 J9 LARYNGOSCOPE JI Laryngoscope PD DEC PY 2013 VL 123 IS 12 BP 3211 EP 3218 DI 10.1002/lary.24168 PG 8 WC Medicine, Research & Experimental; Otorhinolaryngology SC Research & Experimental Medicine; Otorhinolaryngology GA 256LA UT WOS:000327310500073 PM 23918509 ER PT J AU Park, BS Henning, PC Grant, SC Lee, WJ Lee, SR Arjmandi, BH Kim, JS AF Park, Bong-Sup Henning, Paul C. Grant, Samuel C. Lee, Won Jun Lee, Sang-Rok Arjmandi, Bahram H. Kim, Jeong-Su TI HMB attenuates muscle loss during sustained energy deficit induced by calorie restriction and endurance exercise SO METABOLISM-CLINICAL AND EXPERIMENTAL LA English DT Article DE Mice; Catabolic; Body composition; Functionality; Protein degradation ID HYDROXY-BETA-METHYLBUTYRATE; SKELETAL-MUSCLE; PROTEIN-SYNTHESIS; BODY-FAT; MYOSTATIN; SUPPLEMENTATION; ATROPHY; RATS; HYPERTROPHY; PROTEOLYSIS AB Objective. To investigate the efficacy and underlying mechanisms of beta-hydroxy-beta-methylbutyrate (HMB) on body composition, muscle mass and physical performance under catabolic versus normal training conditions. Materials/Methods. Mice were divided into four groups (n = 10/group): 1) ALT = ad libitum + trained (1 h/d for 3 d/wk); 2) ALTH = ALT + HMB (0.5 g/kg BW/d); 3) C = calorie restricted (-30%) + trained (6 h/d, 6 d/wk); and 4) CH = C + HMB. Repeated in vivo assessments included body composition, grip strength and sensorimotor coordination before and after the experimental protocol, while in vitro analyses included muscle wet weights, expression of selected genes and proteins regulating muscle mass, and myofiber cross-sectional area. ANOVAs were used with significance set at p < 0.05. Results. ALTH had greater lean mass than ALT and sensorimotor function increased in ALTH, but decreased in ALT under normal training conditions. Grip strength decreased only in C, but was maintained in CH. Gastrocnemius mass and myofiber CSA were greater in CH than C following catabolic conditions. Gastrocnemius atrogin-1 mRNA expression was elevated in C but not in CH compared to all other groups whereas atrogin-1 protein levels showed no significant changes. Conclusion. HMB improves body composition and sensorimotor function during normal training and attenuates muscle mass and strength loss during catabolic conditions. (C) 2013 Elsevier Inc. All rights reserved. C1 [Park, Bong-Sup; Henning, Paul C.; Lee, Won Jun; Lee, Sang-Rok; Arjmandi, Bahram H.; Kim, Jeong-Su] Florida State Univ, Dept Nutr Food & Exercise Sci, Coll Human Sci, Tallahassee, FL 32306 USA. [Grant, Samuel C.] Florida State Univ, Natl High Magnet Field Lab, Tallahassee, FL 32306 USA. [Grant, Samuel C.] Florida State Univ, Dept Chem & Biomed Engn, Tallahassee, FL 32306 USA. [Henning, Paul C.] US Army Res Inst Environm Med, Mil Performance Div, Natick, MA USA. [Lee, Won Jun] Ewha Womans Univ, Dept Exercise Sci, Seoul, South Korea. RP Kim, JS (reprint author), Florida State Univ, Dept Nutr Food & Exercise Sci, 432 Sandels Bldg, Tallahassee, FL 32306 USA. RI Grant, Samuel/D-8744-2013 OI Grant, Samuel/0000-0001-7738-168X FU National Research Foundation of Korea; Korean Government [NRF-2010-356-G00014]; Florida State University and Metabolic Technologies, Inc. FX This work was partially supported by The National Research Foundation of Korea Grant funded by the Korean Government [NRF-2010-356-G00014], The Florida State University and Metabolic Technologies, Inc. NR 35 TC 9 Z9 10 U1 0 U2 10 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0026-0495 EI 1532-8600 J9 METABOLISM JI Metab.-Clin. Exp. PD DEC PY 2013 VL 62 IS 12 BP 1718 EP 1729 DI 10.1016/j.metabol.2013.06.005 PG 12 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA 257WO UT WOS:000327418700004 PM 23876188 ER PT J AU Robins, K Stankorb, SM Salgueiro, M AF Robins, Kathleen Stankorb, Susan M. Salgueiro, Marybeth TI Energy Expenditure in Acute Posttraumatic Amputation: Comparison of Four Methods for Assessment SO NUTRITION IN CLINICAL PRACTICE LA English DT Article DE indirect calorimetry; calorimeter; energy metabolism; amputation; resting energy expenditure; predictive equations ID RESTING METABOLIC-RATE; HELD INDIRECT CALORIMETER; HOSPITALIZED-PATIENTS; PREDICTION; NUTRITION; CHILDREN; NEEDS; VALIDATION; EQUATIONS; AMPUTEES AB Background: Adequate energy intake is a component of successful recovery after injury, yet little is known about the energy requirements in the acute period following traumatic amputation. The purpose of this study was to compare the clinical applicability of resting energy expenditure (REE) measured by a handheld calorimeter and estimated by 3 different predictive equations to that measured by the gold standard, indirect calorimetry using a metabolic cart, during the acute postamputation period of inpatient hospitalization. Materials and Methods: Indirect calorimetry measured using both a metabolic cart and handheld calorimeter and predicted by 3 equations were used to assess energy needs of eligible subjects admitted to Brooke Army Medical Center with traumatic amputation(s). REE measured by the handheld calorimeter and estimated using 3 predictive equations (Mifflin St. Jeor, Ireton-Jones 1992, and the American College of Chest Physicians [ACCP]) were compared to the gold standard metabolic cart. Each measure was assessed for significant differences and level of clinical acceptability defined as +/- 10% REE by metabolic cart. Results: Thirteen male service members with traumatic amputation(s) were included. The majority of subject's measurements using the handheld calorimeter (n = 9, 69%) and 3 predictive equations (Mifflin St. Jeor [n = 7, 54%], Ireton-Jones 1992 [n = 8, 62%], ACCP [n = 7, 54%]) fell outside of the +/- 10% range of clinical acceptability. Conclusion: Use of the metabolic cart for measuring energy needs remains optimal in this population. C1 [Robins, Kathleen; Stankorb, Susan M.; Salgueiro, Marybeth] Brooke Army Med Ctr, San Antonio, TX 78248 USA. [Stankorb, Susan M.; Salgueiro, Marybeth] Baylor Univ, US Mil, Grad Program Nutr, Waco, TX 76798 USA. RP Salgueiro, M (reprint author), Brooke Army Med Ctr, MCHE DF, 3551 Roger Brooke Dr, San Antonio, TX 78248 USA. EM marybeth.salgueiro.mil@mail.mil NR 46 TC 4 Z9 4 U1 1 U2 5 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0884-5336 EI 1941-2452 J9 NUTR CLIN PRACT JI Nutr. Clin. Pract. PD DEC PY 2013 VL 28 IS 6 BP 758 EP 765 DI 10.1177/0884533613507605 PG 8 WC Nutrition & Dietetics SC Nutrition & Dietetics GA 256JE UT WOS:000327305500016 PM 24170581 ER PT J AU Smolinsky, JA Diehl, RH Radzio, TA Delaney, DK Moore, FR AF Smolinsky, Jaclyn A. Diehl, Robert H. Radzio, Thomas A. Delaney, David K. Moore, Frank R. TI Factors influencing the movement biology of migrant songbirds confronted with an ecological barrier SO BEHAVIORAL ECOLOGY AND SOCIOBIOLOGY LA English DT Article DE Catharus ustulatus; Ecological barrier; Energetic condition; Migration; Stopover duration; Swainson's thrush ID WARBLERS ACROCEPHALUS-SCIRPACEUS; AGE-RELATED DIFFERENCES; PASSERINE MIGRANTS; BIRD MIGRATION; STOPOVER DURATION; FAT DEPOSITION; ENERGETIC CONDITION; REVERSE MIGRATION; SPRING MIGRATION; ORIENTATION AB Whether or not a migratory songbird embarks on a long-distance flight across an ecological barrier is likely a response to a number of endogenous and exogenous factors. During autumn 2008 and 2009, we used automated radio tracking to investigate how energetic condition, age, and weather influenced the departure timing and direction of Swainson's thrushes (Catharus ustulatus) during migratory stopover along the northern coast of the Gulf of Mexico. Most birds left within 1 h after sunset on the evening following capture. Those birds that departed later on the first night or remained longer than 1 day were lean. Birds that carried fat loads sufficient to cross the Gulf of Mexico generally departed in a seasonally appropriate southerly direction, whereas lean birds nearly always flew inland in a northerly direction. We did not detect an effect of age or weather on departures. The decision by lean birds to reorient movement inland may reflect the suitability of the coastal stopover site for deposition of fuel stores and the motivation to seek food among more extensive forested habitat away from the barrier. C1 [Smolinsky, Jaclyn A.] Univ Delaware, Dept Entomol & Wildlife Ecol, Newark, DE 19716 USA. [Diehl, Robert H.] US Geol Survey, Northern Rocky Mt Sci Ctr, Bozeman, MT 59715 USA. [Radzio, Thomas A.] Drexel Univ, Dept Biodivers Earth & Environm Sci, Philadelphia, PA 19104 USA. [Delaney, David K.] US Army Construct Engn Res Lab, Champaign, IL 61826 USA. [Moore, Frank R.] Univ So Mississippi, Hattiesburg, MS 39406 USA. RP Diehl, RH (reprint author), US Geol Survey, Northern Rocky Mt Sci Ctr, 2327 Univ Way,Suite 2, Bozeman, MT 59715 USA. EM rhdiehl@usgs.gov FU U.S. Army Construction Engineering Research Laboratory (USACERL); University of Southern Mississippi, Birmingham Audubon Society; American Ornithologists' Union FX We regret the loss of our friend and colleague, Arlo Raim, who relentlessly radio tracked birds and died shortly after the conclusion of this study. Bill Cochran, Jim Cochran, and Tony Borries offered valuable technical support. Mason Cline, Kristin Comolli, Elizabeth Donadio, Erin Gnass, Joanna Hatt, Jennifer Mizen, Nikita Chernetsov, and members of the Migratory Bird Research Group provided important assistance in the field. Blanton Blankenship of Fort Morgan Historic Park and Jereme Phillips and Jackie Isaacs of Bon Secour National Wildlife Refuge provided access to habitats along the Fort Morgan peninsula used for netting and radio tracking. The USACERL provided the automated radio telemetry systems for use on this project. This work was supported by the U.S. Army Construction Engineering Research Laboratory (USACERL), The University of Southern Mississippi, Birmingham Audubon Society, and The American Ornithologists' Union. Any use of trade, product, or firm names is for descriptive purposes only and does not imply endorsement by the U.S. Government. NR 65 TC 27 Z9 28 U1 7 U2 65 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0340-5443 EI 1432-0762 J9 BEHAV ECOL SOCIOBIOL JI Behav. Ecol. Sociobiol. PD DEC PY 2013 VL 67 IS 12 BP 2041 EP 2051 DI 10.1007/s00265-013-1614-6 PG 11 WC Behavioral Sciences; Ecology; Zoology SC Behavioral Sciences; Environmental Sciences & Ecology; Zoology GA 253HF UT WOS:000327074200013 ER PT J AU Sondeen, JL de Guzman, R Polykratis, IA Prince, MD Hernandez, O Cap, AP Dubick, MA AF Sondeen, Jill L. de Guzman, Rodolfo Polykratis, Irene Amy Prince, Malcolm Dale Hernandez, Orlando Cap, Andrew P. Dubick, Michael A. TI Comparison between human and porcine thromboelastograph parameters in response to ex-vivo changes to platelets, plasma, and red blood cells SO BLOOD COAGULATION & FIBRINOLYSIS LA English DT Article DE blood platelets; fibrinogen; hematocrit; humans; pigs; thrombelastography ID RANDOMIZED CONTROLLED-TRIAL; TRAUMA PATIENTS; POSTINJURY COAGULOPATHY; TRANSFUSION; COAGULATION; THROMBELASTOGRAPHY; RESUSCITATION; MODEL; HEMOSTASIS; MANAGEMENT AB In the acute care setting, both the tracings and numeric outputs (R time, angle, and MA) of thrombelastography (TEG) may be used to inform treatment decisions. The objective was to determine the sensitivity of TEG to isolated changes in platelet count, hematocrit and fibrinogen concentration in human blood. As pigs have a similar coagulation system, we also compared the responses of the pig blood. Eight volunteers (>18years of age, no anticoagulation or nonsteroidal anti-inflammatory therapy, not pregnant) were enrolled into this study. Four female anesthetized donor pigs were instrumented percutaneously with a catheter for blood collection. All blood was collected into sodium citrate. The concentration of each component (platelets, fibrinogen, and red blood cells) was changed while keeping the other components constant by use of centrifugation or preparation of each individual's plasma into platelet poor plasma, platelet rich plasma, cryoprecipitate, purified washed platelets, and packed red blood cells as appropriate. TEG (Haemoscope) analysis was performed and compared with the patients' whole blood diluted with lactated Ringer's solution. We demonstrated that the major factor affecting the MA and angle was the platelet count. In fact, reducing platelets alone resulted in TEG profiles and parameters that were similar to lactated Ringer's dilution profiles. Swine blood responses were parallel to that of human blood, although there were offsets especially of TEG-R and angle that confirmed that the swine are hypercoagulable compared with humans. Superficially similar TEG tracing patterns can be produced by divergent mechanisms associated with altered concentrations of blood components. (C) 2013 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins. C1 [Sondeen, Jill L.; de Guzman, Rodolfo; Polykratis, Irene Amy; Prince, Malcolm Dale; Hernandez, Orlando; Cap, Andrew P.; Dubick, Michael A.] US Army Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Sondeen, JL (reprint author), US Army Inst Surg Res, JBSA, 3698 Chambers Pass, Ft Sam Houston, TX 78234 USA. EM jill.l.sondeen.civ@mail.mil FU US Army Medical Research and Materiel Command FX This study was supported by the US Army Medical Research and Materiel Command. NR 26 TC 10 Z9 10 U1 3 U2 13 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0957-5235 EI 1473-5733 J9 BLOOD COAGUL FIBRIN JI Blood Coagul. Fibrinolysis PD DEC PY 2013 VL 24 IS 8 BP 818 EP 829 DI 10.1097/MBC.0b013e3283646600 PG 12 WC Hematology SC Hematology GA 249XY UT WOS:000326815600005 PM 24047887 ER PT J AU Wang, YS Huynh, G Williamson, C AF Wang, Yansen Huynh, Giap Williamson, Chatt TI Integration of Google Maps/Earth with microscale meteorology models and data visualization SO COMPUTERS & GEOSCIENCES LA English DT Article DE Model result visualization; Model Google GIS integration; Microscale meteorology ID TRANSFORMATION AB The Google Maps/Earth GIS has been integrated with a microscale meteorological model to improve the system's functionality and ease of use. Almost all the components of the model system, including the terrain data processing, morphological data generation, meteorological data gathering and initialization, and displaying/visualizing the model results, have been improved by using this approach. Different from the traditional stand-along model system, this novel system takes advantages of enormous resources in map and image data retrieving/handling, four-dimensional (space and time) data visualization, overlaying, and many other advanced GIS features that the Google Maps/Earth platform has to offer. We have developed modular components for all of the model system controls and data processing programs which are glued together with the JavaScript language and KML/XML data. We have also developed small modular software using the Google application program interface to convert the model results and intermediate data for visualizations and animations. Capabilities such as high-resolution image, street view, and 3D buildings in the Google Earth/Map are also used to quickly generate small-scale vegetation and building morphology data that are required for the microscale meteorological models. This system has also been applied to visualize the data from other instruments such as Doppler wind lidars. Because of the tight integration of the internet based GIS and a microscale meteorology model, the model system is more versatile, intuitive, and user-friendly than a stand-along system we had developed before. This kind of system will enhance the user experience and also help researchers to explore new phenomena in fine-scale meteorology. Published by Elsevier Ltd. C1 [Wang, Yansen; Huynh, Giap; Williamson, Chatt] US Army, Res Lab, Adelphi, MD 20783 USA. RP Wang, YS (reprint author), US Army, Atmospher Dynam Branch, Res Lab, ATTN RDRL CIE D, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM yansen.wang.civ@mail.mil NR 20 TC 15 Z9 17 U1 2 U2 34 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0098-3004 EI 1873-7803 J9 COMPUT GEOSCI-UK JI Comput. Geosci. PD DEC PY 2013 VL 61 BP 23 EP 31 DI 10.1016/j.cageo.2013.07.016 PG 9 WC Computer Science, Interdisciplinary Applications; Geosciences, Multidisciplinary SC Computer Science; Geology GA 252JD UT WOS:000327000100003 ER PT J AU George, AA Fuller, GN Langford, LA Simon, CD Zingalis, AA Mathis, DA AF George, Alan A. Fuller, Gregory N. Langford, Lauren A. Simon, Clayton D. Zingalis, Amy A. Mathis, Derek A. TI Unusual presentation of a granular cell astrocytoma SO HISTOPATHOLOGY LA English DT Letter ID GLIOBLASTOMA; FEATURES C1 [George, Alan A.; Simon, Clayton D.; Zingalis, Amy A.; Mathis, Derek A.] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. [Fuller, Gregory N.; Langford, Lauren A.] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA. RP George, AA (reprint author), Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. OI Fuller, Gregory/0000-0001-9447-2647 NR 6 TC 1 Z9 1 U1 0 U2 3 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0309-0167 EI 1365-2559 J9 HISTOPATHOLOGY JI Histopathology PD DEC PY 2013 VL 63 IS 6 BP 883 EP 885 DI 10.1111/his.12236 PG 3 WC Cell Biology; Pathology SC Cell Biology; Pathology GA 252PB UT WOS:000327018300017 PM 24102930 ER PT J AU Cancio, LC Batchinsky, AI Baker, WL Necsoiu, C Salinas, J Goldberger, AL Costa, MD AF Cancio, Leopoldo C. Batchinsky, Andriy I. Baker, William L. Necsoiu, Corina Salinas, Jose Goldberger, Ary L. Costa, Madalena D. TI Combat casualties undergoing lifesaving interventions have decreased heart rate complexity at multiple time scales SO JOURNAL OF CRITICAL CARE LA English DT Article DE Electrocardiography; Entropy; Heart rate; Nonlinear dynamics; Wounds and injuries; Iraq War 2003 ID TRAUMA PATIENTS; RATE-VARIABILITY; HEMORRHAGIC-SHOCK; AMERICAN-COLLEGE; SERIES ANALYSIS; MORTALITY; PREDICTION; LACTATE; COMMITTEE; PRESSURE AB Purpose: We found that heart rate (HR) complexity metrics such as sample entropy (SampEn) identified patients with trauma receiving lifesaving interventions (LSIs). We now aimed (1) to test a multiscale entropy (MSE) index, (2) to compare it to single-scale measures including SampEn, and (3) to assess different parameter values for calculation of SampEn and MSE. Methods: This was a study of combat casualties in an emergency department in Iraq. Electrocardiograms of 70 acutely injured adults were recorded. Twelve underwent LSIs and 58 did not. Lifesaving interventions included endotracheal intubation (9), tube thoracostomy (9), and emergency transfusion (4). From each electrocardiogram, a segment of 800 consecutive beats was selected. Offline, R waves were detected and R-to-R interval time series were generated. Sample entropy, MSE, and time-domain measures of HR variability (mean HR, SD, the proportion of pairs of consecutive NN intervals that differ by more than 20 and 50 milliseconds, square root of the mean of the squares of differences between adjacent NN intervals) were computed. Results: Differences in mean HR (LSI: 111 +/- 33, non-LSI: 90 +/- 17 beats/min) were not significant. Systolic arterial pressure was statistically but not clinically different (LSI: 123 +/- 19, non-LSI: 135 +/- 19 mm Hg). Sample entropy (LSI: 0.90 +/- 0.42, non-LSI: 1.19 +/- 0.35; P < .05) and MSE index (LSI: 2.58 +/- 2.55, non-LSI: 5.67 +/- 2.48; P < .001) differed significantly. Conclusions: Complexity of HR dynamics over a range of time scales was lower in high-risk than in low-risk combat casualties and outperformed traditional vital signs. Published by Elsevier Inc. C1 [Cancio, Leopoldo C.; Batchinsky, Andriy I.; Baker, William L.; Necsoiu, Corina; Salinas, Jose] US Army Inst Surg Res, Ft Sam Houston, TX USA. [Goldberger, Ary L.; Costa, Madalena D.] Harvard Univ, Beth Israel Deaconess Med Ctr, Sch Med, Boston, MA 02215 USA. [Goldberger, Ary L.; Costa, Madalena D.] Harvard Univ, Wyss Inst Biol Inspired Engn, Boston, MA 02115 USA. RP Cancio, LC (reprint author), US Army Burn Ctr, US Army Inst Surg Res, 3698 Chambers Pass, Ft Sam Houston, TX 78234 USA. EM divego99@gmail.com FU Comprehensive Intensive Care Research Task Area, Combat Casualty Care Research Area Directorate, US Army Medical Research and Materiel Command, Ft. Detrick, MD; Wyss Institute for Biologically Inspired Engineering; G. Harold and Leila Y. Mathers Charitable Foundation; James S. McDonnell Foundation [R00AG030677]; National Institutes of Health [R00AG030677] FX This work was supported by the Comprehensive Intensive Care Research Task Area, Combat Casualty Care Research Area Directorate, US Army Medical Research and Materiel Command, Ft. Detrick, MD; the Wyss Institute for Biologically Inspired Engineering (A.L.G. and M.D.C.); the G. Harold and Leila Y. Mathers Charitable Foundation (A.L.G. and M.D.C.); the James S. McDonnell Foundation (M.D.C.); and the National Institutes of Health Grants R00AG030677 (M.D.C.) and R01GM104987 (A.L.G.). The authors gratefully acknowledge the members of the deployed research team and Ms Annette McClinton, RN, who coordinated activities of the team, as well as Mr John A. Jones for statistical analysis and Dr Tom Kuusela for important discussions on signal analysis. NR 38 TC 11 Z9 11 U1 0 U2 7 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0883-9441 EI 1557-8615 J9 J CRIT CARE JI J. Crit. Care PD DEC PY 2013 VL 28 IS 6 BP 1093 EP 1098 DI 10.1016/j.jcrc.2013.08.022 PG 6 WC Critical Care Medicine SC General & Internal Medicine GA 251QN UT WOS:000326945100037 PM 24140167 ER PT J AU Berg, MJ Videen, G AF Berg, Matthew J. Videen, Gorden TI Concepts in electromagnetic scattering for particulate-systems characterization Preface SO JOURNAL OF QUANTITATIVE SPECTROSCOPY & RADIATIVE TRANSFER LA English DT Editorial Material C1 [Berg, Matthew J.] Mississippi State Univ, Dept Phys & Astron, Mississippi State, MS 39762 USA. [Videen, Gorden] US Army Res Lab, Adelphi, MD 20783 USA. RP Berg, MJ (reprint author), Mississippi State Univ, Dept Phys & Astron, Mississippi State, MS 39762 USA. EM mberg81@gmail.com NR 0 TC 1 Z9 1 U1 1 U2 6 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0022-4073 EI 1879-1352 J9 J QUANT SPECTROSC RA JI J. Quant. Spectrosc. Radiat. Transf. PD DEC PY 2013 VL 131 SI SI BP 1 EP 2 DI 10.1016/j.jqsrt.2013.04.024 PG 2 WC Optics; Spectroscopy SC Optics; Spectroscopy GA 255GK UT WOS:000327227200001 ER PT J AU Aptowicz, KB Pan, YL Martin, SD Fernandez, E Chang, RK Pinnick, RG AF Aptowicz, Kevin B. Pan, Yong-Le Martin, Sean D. Fernandez, Elena Chang, Richard K. Pinnick, Ronald G. TI Decomposition of atmospheric aerosol phase function by particle size and asphericity from measurements of single particle optical scattering patterns SO JOURNAL OF QUANTITATIVE SPECTROSCOPY & RADIATIVE TRANSFER LA English DT Article DE Light scattering; Phase function; Atmospheric aerosol; Morphology; Asphericity; Autocorrelation ID LIGHT-SCATTERING; NONSPHERICAL PARTICLES; FLUORESCENCE-SPECTRA; DEFORMED DROPLETS; SPHEROIDS; SHAPE; CLASSIFICATION; VARIABILITY; INCLUSIONS; MARYLAND AB We demonstrate an experimental approach that provides insight into how particle size and shape affect the scattering phase function of atmospheric aerosol particles. Central to our approach is the design of an apparatus that measures the forward and backward scattering hemispheres (scattering patterns) of individual atmospheric aerosol particles in the coarse mode range. We captured over 30 000 scattering patterns during winter (January 2007) at an urban site in Las Cruces, NM. The size and shape of each particle is discerned from the corresponding scattering pattern. In particular, autocorrelation analysis is used to differentiate between spherical and non-spherical particles, the calculated asphericity factor is used to characterize the morphology of non-spherical particles, and the integrated irradiance is used for particle sizing. We found that the fraction of spherical particles decays exponentially with particle size, decreasing from 11% for particles on the order of 1 mu m to less than 1% for particles over 5 mu m. The average phase functions of subpopulations of particles, grouped by size and morphology, are determined by averaging their corresponding scattering patterns. The phase functions of spherical and non-spherical atmospheric particles are shown to diverge with increasing size. In addition, the phase function of non-spherical particles is found to vary little as a function of the asphericity factor. Our results support the current remote sensing practice of characterizing atmospheric aerosol particles as a composition of spherical and non-spherical particles with less concern about the diversity of morphology within nonspherical particles. In addition, our results suggest that assuming a constant spherical fraction independent of particle size may not accurately reflect the real morphological distribution of atmospheric aerosol particles. (C) 2013 Elsevier Ltd. All rights reserved. C1 [Aptowicz, Kevin B.; Martin, Sean D.] W Chester Univ, Dept Phys, W Chester, PA 19383 USA. [Pan, Yong-Le; Pinnick, Ronald G.] US Army Res Lab, Adelphi, MD 20783 USA. [Fernandez, Elena; Pinnick, Ronald G.] New Mexico State Univ, Dept Phys, Las Cruces, NM 88003 USA. [Chang, Richard K.] Yale Univ, Dept Appl Phys, New Haven, CT 06511 USA. RP Aptowicz, KB (reprint author), W Chester Univ, Dept Phys, W Chester, PA 19383 USA. EM kaptowicz@wcupa.edu FU Defense Threat Reduction Agency under the Physical Science and Technology Basic Research Program; Army Research Laboratory FX This research was supported by the Defense Threat Reduction Agency under the Physical Science and Technology Basic Research Program and by Army Research Laboratory mission funds. We thank Frederick Monson for assistance with operation of the scanning electron microscope. We also acknowledge Alexander Patterson IV for suggesting improvements to our Matlab code and Gordon Videen for providing insight into the utility of our experimental approach to climate research. We also would like to thank the two anonymous reviewers for their insightful comments. NR 47 TC 6 Z9 6 U1 2 U2 25 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0022-4073 EI 1879-1352 J9 J QUANT SPECTROSC RA JI J. Quant. Spectrosc. Radiat. Transf. PD DEC PY 2013 VL 131 SI SI BP 13 EP 23 DI 10.1016/j.jqsrt.2013.03.020 PG 11 WC Optics; Spectroscopy SC Optics; Spectroscopy GA 255GK UT WOS:000327227200003 ER PT J AU Sun, WB Videen, G Fu, Q Hu, YX AF Sun, Wenbo Videen, Gorden Fu, Qiang Hu, Yongxiang TI Scattered-field FDTD and PSTD algorithms with CPML absorbing boundary conditions for light scattering by aerosols SO JOURNAL OF QUANTITATIVE SPECTROSCOPY & RADIATIVE TRANSFER LA English DT Article DE Finite-difference time domain; Pseudo-spectral time-domain; Light scattering; Aerosol particle ID TIME-DOMAIN METHOD; DISCRETE-DIPOLE APPROXIMATION; PERFECTLY MATCHED LAYER; NONSPHERICAL PARTICLES; MAXWELLS EQUATIONS; NUMERICAL-SOLUTION; MEDIA; SIMULATIONS; ABSORPTION; MATRIX AB As fundamental parameters for polarized-radiative-transfer calculations, the single-scattering phase matrix of irregularly shaped aerosol particles must be accurately modeled. In this study, a scattered-field finite-difference time-domain (FDTD) model and a scattered-field pseudospectral time-domain (PSTD) model are developed for light scattering by arbitrarily shaped dielectric aerosols. The convolutional perfectly matched layer (CPML) absorbing boundary condition (ABC) is used to truncate the computational domain. It is found that the PSTD method is generally more accurate than the FDTD in calculation of the single-scattering properties given similar spatial cell sizes. Since the PSTD can use a coarser grid for large particles, it can lower the memory requirement in the calculation. However, the Fourier transformations in the PSTD need significantly more CPU time than simple subtractions in the FDTD, and the fast Fourier transform requires a power of 2 elements in calculations, thus using the PSTD could not significantly reduce the CPU time required in the numerical modeling. Furthermore, because the scattered-field FDTD/PSTD equations include incident-wave source terms, the FDTD/PSTD model allows for the inclusion of an arbitrarily incident wave source, including a plane parallel wave or a Gaussian beam like those emitted by lasers usually used in laboratory particle characterizations, etc. The scattered-field FDTD and PSTD light-scattering models can be used to calculate single-scattering properties of arbitrarily shaped aerosol particles over broad size and wavelength ranges. (C) 2013 Elsevier Ltd. All rights reserved. C1 [Sun, Wenbo] Sci Syst & Applicat Inc, Hampton, VA 23666 USA. [Videen, Gorden] US Army Res Lab, Adelphi, MD 20783 USA. [Fu, Qiang] Univ Washington, Dept Atmospher Sci, Seattle, WA 98195 USA. [Sun, Wenbo; Hu, Yongxiang] NASA, Langley Res Ctr, Hampton, VA 23681 USA. RP Sun, WB (reprint author), NASA, Langley Res Ctr, Mail Stop 420,21 Langley Blvd, Hampton, VA 23681 USA. EM Wenbo.Sun-1@nasa.gov RI Hu, Yongxiang/K-4426-2012; Richards, Amber/K-8203-2015 FU NASA [09-GLORY09-0027] FX This work was supported by NASA Glory fund 09-GLORY09-0027. The authors thank Michael I. Mishchenko and Hal B. Maring for support on this work. NR 31 TC 9 Z9 9 U1 2 U2 15 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0022-4073 EI 1879-1352 J9 J QUANT SPECTROSC RA JI J. Quant. Spectrosc. Radiat. Transf. PD DEC PY 2013 VL 131 SI SI BP 166 EP 174 DI 10.1016/j.jqsrt.2013.07.015 PG 9 WC Optics; Spectroscopy SC Optics; Spectroscopy GA 255GK UT WOS:000327227200022 ER PT J AU Zubko, E Muinonen, K Munoz, O Nousiainen, T Shkuratov, Y Sun, WB Videen, G AF Zubko, Evgenij Muinonen, Karri Munoz, Olga Nousiainen, Timo Shkuratov, Yuriy Sun, Wenbo Videen, Gorden TI Light scattering by feldspar particles: Comparison of model agglomerate debris particles with laboratory samples SO JOURNAL OF QUANTITATIVE SPECTROSCOPY & RADIATIVE TRANSFER LA English DT Article DE Light scattering; Irregular particles; Agglomerated debris; Dust; Feldspar ID DISCRETE-DIPOLE APPROXIMATION; GAUSSIAN RANDOM PARTICLES; RAY OPTICS APPROXIMATION; NEGATIVE POLARIZATION; PHOTOMETRIC PROPERTIES; AEROSOL-PARTICLES; MINERAL AEROSOL; DUST PARTICLES; SIZE; SPHEROIDS AB We present comparisons of the non-zero light-scattering Mueller-matrix elements of agglomerated debris particles with those of well-characterized experimentally measured feldspar samples at blue and red wavelengths. The only completely free parameter in our comparisons is the small-size cut-off of the sample, which was not known. The significance is that both the light scattering and the measured properties of model and real particles agree very well. While some tweaking of the particle parameters could achieve some improvement, the fits are remarkably good, with significant deviations (similar to 5%) occurring in portions of the polarization elements, e.g. S-34. We suggest that the reason for the good fits is not that the model particles exactly represent those of the sample particles, but rather that both sets of particles belong to a class of highly irregular particles, whose high degree of irregularity dominates the resulting scattering behavior, suppressing the effect of any characteristic morphological features. (C) 2013 Elsevier Ltd. All rights reserved. C1 [Zubko, Evgenij; Muinonen, Karri; Nousiainen, Timo] Univ Helsinki, Dept Phys, FI-00014 Helsinki, Finland. [Zubko, Evgenij; Shkuratov, Yuriy] Kharkov Natl Univ, Astron Inst, UA-61022 Kharkov, Ukraine. [Muinonen, Karri] Finnish Geodet Inst, FI-02431 Masala, Finland. [Munoz, Olga] CSIC, Inst Astrofis Andalucia, Granada, Spain. [Sun, Wenbo] Sci Syst & Applicat Inc, Hampton, VA 23666 USA. [Videen, Gorden] Army Res Lab AMSRL CI EM, Adelphi, MD 20783 USA. [Videen, Gorden] Space Sci Inst, Boulder, CO 80301 USA. RP Zubko, E (reprint author), Univ Helsinki, Dept Phys, POB 64, FI-00014 Helsinki, Finland. EM evgenij.zubko@helsinki.fi RI Nousiainen, Timo/A-7982-2008; Richards, Amber/K-8203-2015; OI Nousiainen, Timo/0000-0002-6569-9815; Munoz, Olga/0000-0002-5138-3932 FU Academy of Finland [127461, 125180, 257966]; NASA [NNX10AP93G, NNX11AB25G, 09-GLORY09-0027]; Plan Nacional de Astronomia Astrofisica [AYA2009-08190]; Junta de Andalucia [P09-FMQ-455] FX This work was partially supported by the Academy of Finland (contracts 127461, 125180, and 257966), NASA Outer Planets Research Program (contract NNX10AP93G), NASA Lunar Advanced Science and Exploration Research Program (contract NNX11AB25G), and NASA Glory fund 09-GLORY09-0027, Plan Nacional de Astronomia Astrofisica (contract AYA2009-08190), and Junta de Andalucia, (contract P09-FMQ-455). We thank Prof. O. Dubovik for the digitized data of modeling with the spheroidal model utilized in [3] and two anonymous reviewers for valuable comments on this work. NR 44 TC 19 Z9 19 U1 0 U2 8 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0022-4073 EI 1879-1352 J9 J QUANT SPECTROSC RA JI J. Quant. Spectrosc. Radiat. Transf. PD DEC PY 2013 VL 131 SI SI BP 175 EP 187 DI 10.1016/j.jqsrt.2013.01.017 PG 13 WC Optics; Spectroscopy SC Optics; Spectroscopy GA 255GK UT WOS:000327227200023 ER PT J AU Crosta, GF Pan, YL Aptowicz, KB Casati, C Pinnick, RG Chang, RK Videen, GW AF Crosta, Giovanni Franco Pan, Yong-Le Aptowicz, Kevin B. Casati, Caterina Pinnick, Ronald G. Chang, Richard K. Videen, Gorden W. TI Automated classification of single airborne particles from two-dimensional angle-resolved optical scattering (TAOS) patterns by non-linear filtering SO JOURNAL OF QUANTITATIVE SPECTROSCOPY & RADIATIVE TRANSFER LA English DT Article DE Angle-resolved optical scattering; Machine learning; Airborne particle; Scattering pattern; Feature extraction; Linear classifier; Supervised training; Bacillus subtilis; Outdoor sampling ID LIGHT-SCATTERING; DEFORMED DROPLETS; INCLUSIONS AB Measurement of two-dimensional angle-resolved optical scattering (TAOS) patterns is an attractive technique for detecting and characterizing micron-sized airborne particles. In general, the interpretation of these patterns and the retrieval of the particle refractive index, shape or size alone, are difficult problems. By reformulating the problem in statistical learning terms, a solution is proposed herewith: rather than identifying airborne particles from their scattering patterns, TAOS patterns themselves are classified through a learning machine, where feature extraction interacts with multivariate statistical analysis. Feature extraction relies on spectrum enhancement, which includes the discrete cosine FOURIER transform and non-linear operations. Multivariate statistical analysis includes computation of the principal components and supervised training, based on the maximization of a suitable figure of merit. All algorithms have been combined together to analyze TAOS patterns, organize feature vectors, design classification experiments, carry out supervised training, assign unknown patterns to classes, and fuse information from different training and recognition experiments. The algorithms have been tested on a data set with more than 3000 TAOS patterns. The parameters that control the algorithms at different stages have been allowed to vary within suitable bounds and are optimized to some extent. Classification has been targeted at discriminating aerosolized Bacillus subtilis particles, a simulant of anthrax, from atmospheric aerosol particles and interfering particles, like diesel soot. By assuming that all training and recognition patterns come from the respective reference materials only, the most satisfactory classification result corresponds to 20% false negatives from B. subtilis particles and <11% false positives from all other aerosol particles. The most effective operations have consisted of thresholding TAOS patterns in order to reject defective ones, and forming training sets from three or four pattern classes. The presented automated classification method may be adapted into a real-time operation technique, capable of detecting and characterizing micron-sized airborne particles. (C) 2013 The Authors. Published by Elsevier Ltd. All rights reserved. C1 [Crosta, Giovanni Franco; Casati, Caterina] Univ Milan Bicocca 1, Dept Environm & Earth Sci, I-20126 Milan, Italy. [Pan, Yong-Le; Pinnick, Ronald G.; Videen, Gorden W.] US Army Res Lab, Adelphi, MD 20783 USA. [Aptowicz, Kevin B.] W Chester Univ, Dept Phys, W Chester, PA 19383 USA. [Chang, Richard K.] Yale Univ, Dept Appl Phys, New Haven, CT 06511 USA. RP Crosta, GF (reprint author), Univ Milan Bicocca 1, Dept Environm & Earth Sci, Piazza Sci, I-20126 Milan, Italy. EM Giovanni_Crosta@uml.edu FU US Army Research Development and Communication (RDECOM) ACQ CTR [W911NF 11-1-0277 RD 1449-BC-01] FX This investigation is supported by contract W911NF 11-1-0277 R&D 1449-BC-01 (the Contract) granted to Universita Milan-Bicocca by the US Army Research Development and Communication (RDECOM) ACQ CTR, which is gratefully acknowledged herewith. CATERINA CASATI, MSc, was supported by the contract through a fellowship grant. All authors gratefully acknowledge the remarks and constructive criticism by the editor and the referees. NR 31 TC 5 Z9 5 U1 1 U2 12 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0022-4073 EI 1879-1352 J9 J QUANT SPECTROSC RA JI J. Quant. Spectrosc. Radiat. Transf. PD DEC PY 2013 VL 131 SI SI BP 215 EP 233 DI 10.1016/j.jqsrt.2013.06.009 PG 19 WC Optics; Spectroscopy SC Optics; Spectroscopy GA 255GK UT WOS:000327227200027 ER PT J AU Sanders, DM Schuster, AL McCardle, PW Strey, OF Blankenship, TL Teel, PD AF Sanders, David M. Schuster, Anthony L. McCardle, P. Wesley Strey, Otto F. Blankenship, Terry L. Teel, Pete D. TI Ixodid ticks associated with feral swine in Texas SO JOURNAL OF VECTOR ECOLOGY LA English DT Article DE Ticks; Ixodidae; feral swine; pigs ID BOAR SUS-SCROFA; CERVUS-ELAPHUS-HISPANICUS; UNITED-STATES; SEROLOGIC SURVEY; SOUTHERN TEXAS; WILD HOGS; ACARI; SPAIN; DEER; PREVALENCE AB Ixodid ticks were collected from feral swine in eight Texas ecoregions from 2008-2011. Sixty-two percent of 806 feral swine were infested with one or more of the following species: Amblyomma americanum, A. cajennense, A. maculatum, Dermacentor albipictus, D. halli, D. variabilis, and Ixodes scapularis. Juvenile and adult feral swine of both sexes were found to serve as host to ixodid ticks. Longitudinal surveys of feral swine at four geographic locations show persistent year-round tick infestations of all gender-age classes for tick species common to their respective geographic locations and ecoregions. Amblyomma americanum, A. cajennense, A. maculatum and D. variabilis were collected from 66% of feral swine harvested through an abatement program in seven ecoregions from March to October in 2009. These results indicate westward geographic expansion of D. variabilis. Summary results show feral swine are competent hosts for ixodid species responsible for the transmission of pathogens and diminished well-being in livestock, wildlife, and humans. C1 [Sanders, David M.] USAFSAM, US Air Force Res Lab, Wright Patterson AFB, OH 45433 USA. [Schuster, Anthony L.; McCardle, P. Wesley] Armed Forces Res Inst Med Sci, US Army Med Component, Bangkok 10400, Thailand. [Strey, Otto F.; Teel, Pete D.] Texas A&M Univ, Texas A&M AgriLife Res, Dept Entomol, College Stn, TX 77843 USA. [Blankenship, Terry L.] Welder Wildlife Fdn, Sinton, TX 78387 USA. RP Teel, PD (reprint author), Texas A&M Univ, Texas A&M AgriLife Res, Dept Entomol, College Stn, TX 77843 USA. EM pteel@tamu.edu FU Texas A&M AgriLife Research Project [TEX08911]; Department of Defense Education Program; Deployed Warfighter Protection Program; Air Force Research Laboratory; Welder Wildlife Foundation; Camp Bullis Military Reservation; Fort Hood Military Reservation; Texas Department of Corrections; Anderson Ranch LLC FX We gratefully acknowledge collaborations with the Welder Wildlife Foundation, Camp Bullis Military Reservation, Fort Hood Military Reservation, the Texas Department of Corrections and Anderson Ranch LLC for permitting and supporting the long-term studies. In particular, we are indebted to Mr. Lucas Cooksey, Mr. Kevin Cagle, Dr. Fred Anderson, and Major Michael Owen for their assistance. We are similarly indebted to Ms. Jeneane Romaines and her staff of the Texas A&M AgriLife Extension, Wildlife Services, feral hog abatement program for samples collected on a state-wide scale. This project was supported in parts by Texas A&M AgriLife Research Project TEX08911, the Department of Defense Education Program, Deployed Warfighter Protection Program, and the Air Force Research Laboratory. The conclusions and opinions expressed by the authors in this manuscript do not reflect the opinions of the US Army, US Air Force, or the Department of Defense. NR 52 TC 4 Z9 4 U1 3 U2 11 PU SOC VECTOR ECOLOGY PI CORONA PA 1966 COMPTON AVE, CORONA, CA 92881 USA SN 1081-1710 EI 1948-7134 J9 J VECTOR ECOL JI J. Vector Ecol. PD DEC PY 2013 VL 38 IS 2 BP 361 EP 373 PG 13 WC Entomology SC Entomology GA 251JC UT WOS:000326923500022 PM 24581367 ER PT J AU Guo, YZ Behm, NA Ligda, JP Li, YL Pan, Z Horita, Z Wei, Q AF Guo, Y. Z. Behm, N. A. Ligda, J. P. Li, Y. L. Pan, Z. Horita, Z. Wei, Q. TI Critical issues related to instrumented indentation on non-uniform materials: Application to niobium subjected to high pressure torsion SO MATERIALS SCIENCE AND ENGINEERING A-STRUCTURAL MATERIALS PROPERTIES MICROSTRUCTURE AND PROCESSING LA English DT Article DE Nanoindentation; Strain rate sensitivity; Niobium; High pressure torsion; Pile-up ID STRAIN-RATE SENSITIVITY; SEVERE PLASTIC-DEFORMATION; CHANNEL ANGULAR EXTRUSION; ULTRAFINE GRAIN SIZES; MECHANICAL-PROPERTIES; GRADIENT PLASTICITY; ELASTIC-MODULUS; MICROSTRUCTURAL EVOLUTION; CONICAL INDENTATION; BCC METALS AB Nanoindentation is a powerful tool for characterizing the mechanical properties of materials at small length scales. Since the loading rate can be accurately recorded and controlled during a nanoindentation test, the strain rate dependence of these properties can also be determined. However, there are still a few problems that need to be addressed when it is applied to some special materials. High pressure torsion (HPT) processed metals are examples of these materials with non-uniform microstructures and mechanical properties. In this work, commercially pure niobium disks with diameter of similar to 10.0 mm and thickness of similar to 1.0 mm were processed by HPT. Grain sizes from a few nanometers to a few micrometers were generated due to a strong radial strain gradient in the disk. Instrumented nanoindentation tests were conducted at different radial locations of the HPT niobium disk. During each test, the loading rate was controlled so that the indentation strain rate was kept constant. Some key issues associated with the nanoindentation experiment, such as contact stiffness, contact area and the effect of pile-up or sink-in were evaluated and discussed carefully. The work-based method was used in data processing and it was compared with other approaches. The effects of indentation location, i.e., grain size, as well as indentation strain rate were characterized. (C) 2013 Elsevier B.V. All rights reserved. C1 [Guo, Y. Z.; Li, Y. L.] Northwestern Polytech Univ, Sch Aeronaut, Xian 710072, Shaanxi, Peoples R China. [Behm, N. A.] Univ N Carolina, Nanoscale Sci PhD Program, Charlotte, NC 28223 USA. [Ligda, J. P.] US Army Res Lab, WMRD, Aberdeen, MD 21005 USA. [Pan, Z.; Wei, Q.] Univ N Carolina, Dept Mech Engn, Charlotte, NC 28223 USA. [Horita, Z.] Kyushu Univ, Dept Mat Sci & Engn, Fac Engn, Fukuoka 8190395, Japan. [Horita, Z.] Kyushu Univ, Int Inst Carbon Neutral Energy Res WPI I2CNER, WPI, Fukuoka 8190395, Japan. RP Wei, Q (reprint author), Univ N Carolina, Dept Mech Engn, Charlotte, NC 28223 USA. EM guoyazhou@nwpu.edu.cn; qwei@uncc.edu RI Wei, Qiuming/B-7579-2008; Guo, Yazhou/E-3318-2016; U-ID, Kyushu/C-5291-2016; Pan, Zhiliang/A-8061-2009 OI Pan, Zhiliang/0000-0003-3899-8761 FU National Natural Science Foundation of China [11102166, 10932008]; 111 Project [B07050]; Basic Research Foundation of NPU [JC201201]; US Army Research Laboratory [W911QX-06-C-0124, W911QX-08-C-0073] FX The authors would like to thank the financial support by the National Natural Science Foundation of China (Contract nos. 11102166 and 10932008), the 111 Project (Contract no. B07050), and the Basic Research Foundation of NPU (Contract no. JC201201). Y.Z. Guo would like to thank Dr. X.X. Wu for assistance with AFM. Q Wei thanks the support from the US Army Research Laboratory under Contract nos. W911QX-06-C-0124 and W911QX-08-C-0073. NR 60 TC 5 Z9 5 U1 2 U2 32 PU ELSEVIER SCIENCE SA PI LAUSANNE PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND SN 0921-5093 EI 1873-4936 J9 MAT SCI ENG A-STRUCT JI Mater. Sci. Eng. A-Struct. Mater. Prop. Microstruct. Process. PD DEC 1 PY 2013 VL 586 BP 149 EP 159 DI 10.1016/j.msea.2013.08.015 PG 11 WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Science & Technology - Other Topics; Materials Science; Metallurgy & Metallurgical Engineering GA 251BW UT WOS:000326903800021 ER PT J AU Hinjoy, S Nelson, KE Gibbons, RV Jarman, RG Mongkolsirichaikul, D Smithsuwan, P Fernandez, S Labrique, AB Patchanee, P AF Hinjoy, S. Nelson, K. E. Gibbons, R. V. Jarman, R. G. Mongkolsirichaikul, D. Smithsuwan, P. Fernandez, S. Labrique, A. B. Patchanee, P. TI A Cross-Sectional Study of Hepatitis E Virus Infection in Healthy People Directly Exposed and Unexposed to Pigs in a Rural Community in Northern Thailand SO ZOONOSES AND PUBLIC HEALTH LA English DT Article DE Cross-sectional study; hepatitis E virus; adult; occupational exposure; swine; Thailand ID WILD BOAR; HIGH PREVALENCE; HEV INFECTION; UNITED-STATES; SWINE; EPIDEMIOLOGY; ANTIBODIES; COUNTRIES; TRANSMISSION; NETHERLANDS AB A cross-sectional study of the association between occupational pig exposure and hepatitis E virus (HEV) infection in adult pig farmers and the general population who were not directly exposed to pigs was conducted in Nan Province, Thailand, from November 2010 to April 2011. All participants were interviewed to provide information on their job history, eating habits and other potential confounders. The prevalence of anti-HEV immunoglobulin G antibodies (IgG) among 513 subjects was 23.0%. Hand washing with water and soap was associated with a lower seroprevalence of HEV infection, whereas living in an area with frequent flooding (OR 1.64, 95% CI: 1.00-2.68) and consuming internal pig organs more than twice per week (OR 3.23, 95%CI: 1.15-9.01) were both associated with a higher seroprevalence of anti-HEV IgG. There was no association between HEV seroprevalence and frequent, direct occupational pig contact. C1 [Hinjoy, S.; Smithsuwan, P.] Minist Publ Hlth, Dept Dis Control, Bur Epidemiol, Nonthaburi, Thailand. [Hinjoy, S.; Nelson, K. E.] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA. [Gibbons, R. V.; Mongkolsirichaikul, D.; Fernandez, S.] Armed Forces Inst Med Sci, Dept Virol, Bangkok, Thailand. [Jarman, R. G.] Walter Reed Army Inst Res, Viral Dis Branch, Silver Spring, MD USA. [Labrique, A. B.] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Int Hlth & Epidemiol, Baltimore, MD USA. [Patchanee, P.] Chiang Mai Univ, Fac Vet Med, Dept Food Anim Clin, Chiang Mai 50100, Thailand. RP Patchanee, P (reprint author), Chiang Mai Univ, Fac Vet Med, Dept Food Anim Clin, Chiang Mai 50100, Thailand. EM patprapas@gmail.com RI Mashamba-Thompson, Tivani /B-6087-2014; OI Labrique, Alain/0000-0003-2502-7819 FU World Health Organization (WHO) - South-East Asia Regional Office FX The authors acknowledge with gratitude the individual pig farmers and rural dwellers who participated in the study. Nan Provincial Health Office, Tha Wang Pha Hospital, District Health Office, Primary Health Care Units and communities in Nan province have been helpful in providing facilities for collecting data, and we thank them for their collaboration. We gratefully acknowledge Doctor Alden Henderson and the colleagues from Bureau of Epidemiology, Ministry of Public Health for their help. The support of the World Health Organization (WHO) - South-East Asia Regional Office in providing a doctoral scholarship to Doctor Soawapak Hinjoy is also greatly appreciated. Thanks to Tanawat Likitkererat, Doctor Pravit Choomkasien and Doctor Sopon Iamsirithaworn for advice during the data entry and data analysis. Finally, we thank the staff from the USAMC-AFRIMS in Bangkok for help in the diagnostic testing. NR 36 TC 7 Z9 7 U1 1 U2 5 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1863-1959 EI 1863-2378 J9 ZOONOSES PUBLIC HLTH JI Zoonoses Public Health PD DEC PY 2013 VL 60 IS 8 BP 555 EP 562 DI 10.1111/zph.12030 PG 8 WC Public, Environmental & Occupational Health; Infectious Diseases; Veterinary Sciences SC Public, Environmental & Occupational Health; Infectious Diseases; Veterinary Sciences GA 255QR UT WOS:000327255400006 PM 23280251 ER PT J AU Cartwright, GM Friedrichs, CT Smith, SJ AF Cartwright, Grace M. Friedrichs, Carl T. Smith, S. Jarrell TI A test of the ADV-based Reynolds flux method for in situ estimation of sediment settling velocity in a muddy estuary SO GEO-MARINE LETTERS LA English DT Article ID DOPPLER-VELOCIMETER ADV; TURBULENCE MEASUREMENTS; BOUNDARY-LAYER; FINE SEDIMENT AB Under conditions common in muddy coastal and estuarine environments, acoustic Doppler velocimeters (ADVs) can serve to estimate sediment settling velocity (w (s)) by assuming a balance between upward turbulent Reynolds flux and downward gravitational settling. Advantages of this method include simple instrument deployment, lack of flow disturbance, and relative insensitivity to biofouling and water column stratification. Although this method is being used with increasing frequency in coastal and estuarine environments, to date it has received little direct ground truthing. This study compared in situ estimates of w (s) inferred by a 5-MHz ADV to independent in situ observations from a high-definition video settling column over the course of a flood tide in the bottom boundary layer of the York River estuary, Virginia, USA. The ADV-based measurements were found to agree with those of the settling column when the current speed at about 40 cm above the bed was greater than about 20 cm/s. This corresponded to periods when the estimated magnitude of the settling term in the suspended sediment continuity equation was four or more times larger than the time rate of change of concentration. For ADV observations restricted to these conditions, ADV-based estimates of w (s) (mean 0.48 +/- 0.04 mm/s) were highly consistent with those observed by the settling column (mean 0.45 +/- 0.02 mm/s). However, the ADV-based method for estimating w (s) was sensitive to the prescribed concentration of the non-settling washload, C (wash). In an objective operational definition, C (wash) can be set equal to the lowest suspended solids concentration observed around slack water. C1 [Cartwright, Grace M.; Friedrichs, Carl T.] Virginia Inst Marine Sci, Coll William & Mary, Gloucester Point, VA 23062 USA. [Smith, S. Jarrell] US Army Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Cartwright, GM (reprint author), Virginia Inst Marine Sci, Coll William & Mary, POB 1346, Gloucester Point, VA 23062 USA. EM gracec@vims.edu OI Friedrichs, Carl/0000-0002-1810-900X FU National Science Foundation [OCE-0536572, OCE-1061781] FX We thank VIMS personnel K. Fall, W. Reisner, and C. Wilkerson for their assistance. This work was first reported at the October 2012 "Particles in Europe" Conference in Barcelona, Spain, the main organizer being O. Mikkelsen of Sequoia Scientific, Inc., Bellevue, WA. The manuscript was substantially improved by the insightful reviewer comments of M. Green, G. Voulgaris, and the editors of Geo-Marine Letters. Funding for this research was provided by National Science Foundation grants OCE-0536572 and OCE-1061781. This paper is Contribution No. 3306 of the Virginia Institute of Marine Science, The College of William and Mary. NR 31 TC 6 Z9 6 U1 4 U2 31 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0276-0460 EI 1432-1157 J9 GEO-MAR LETT JI Geo-Mar. Lett. PD DEC PY 2013 VL 33 IS 6 BP 477 EP 484 DI 10.1007/s00367-013-0340-4 PG 8 WC Geosciences, Multidisciplinary; Oceanography SC Geology; Oceanography GA 247FQ UT WOS:000326602000005 ER PT J AU Omotade, TO Heffron, JD Klimko, CP Marchand, CL Miller, LL Halasahoris, SA Bozue, JA Welkos, SL Cote, CK AF Omotade, T. O. Heffron, J. D. Klimko, C. P. Marchand, C. L. Miller, L. L. Halasahoris, S. A. Bozue, J. A. Welkos, S. L. Cote, C. K. TI D-cycloserine or similar physiochemical compounds may be uniquely suited for use in Bacillus anthracis spore decontamination strategies SO JOURNAL OF APPLIED MICROBIOLOGY LA English DT Article DE antimicrobial; Bacillus anthracis; d-cycloserine; decontamination; germination; remediation; spore ID THURINGIENSIS AL-HAKAM; INHALATIONAL ANTHRAX; D-ALANINE; UNITED-STATES; IN-VITRO; MURINE MACROPHAGES; GRUINARD ISLAND; GENOME SEQUENCE; CEREUS SPORES; MOUSE MODEL AB AimsAs observed in the aftermath of the anthrax attacks of 2001, decontamination and remediation of a site contaminated by the accidental or intentional release of Bacillus anthracis spores is difficult, costly and potentially damaging to the environment. The identification of novel strategies that neutralize the threat of spores while minimizing environmental damage remains a high priority. We investigated the efficacy of d-cycloserine (DCS), an antibiotic and inhibitor of the spore-associated enzyme (alanine racemase) responsible for converting l-alanine to d-alanine, as a spore germination enhancer and antimicrobial agent. Methods and ResultsWe characterized the impact of DCS exposure on both germinating spores and vegetative cells of fully virulent B.anthracis by evaluating spore germination kinetics, determining the minimum inhibitory concentrations (MICs) required to affect growth of the bacteria and performing macrophage viability assays. DCS enhanced germination induced by l-alanine and also efficiently killed the newly germinated spores. Furthermore, DCS proved nontoxic to macrophages at concentrations that provided protection from the killing effects of spores. Similar tests were conducted with Bacillus thuringiensis (subspecies kurstaki and Al Hakam) to determine its potential as a possible surrogate for B.anthracis field trials. Bacillus thuringiensis spores responded in a similar manner to B.anthracis spores when exposed to DCS. ConclusionsThese results further support that DCS augments the germination response of spores in the presence of l-alanine but also reveal that DCS is bactericidal towards germinating spores. Significance and Impact of the StudyDCS (or similar compounds) may be uniquely suited for use as part of decontamination strategies by augmenting the induction of spore germination and then rendering the germinated spores nonviable. C1 [Omotade, T. O.; Heffron, J. D.; Klimko, C. P.; Marchand, C. L.; Miller, L. L.; Halasahoris, S. A.; Bozue, J. A.; Welkos, S. L.; Cote, C. K.] US Army, Bacteriol Div, Army Med Res Inst Infect Dis, Frederick, MD 21702 USA. RP Cote, CK (reprint author), US Army, Bacteriol Div, Army Med Res Inst Infect Dis, 1425 Porter St, Frederick, MD 21702 USA. EM christopher.cote2@us.army.mil FU Defense Threat Reduction Agency JSTO-CBD plan [CBT-PHM-12-CB2-CB3831] FX The research described herein was sponsored by the Defense Threat Reduction Agency JSTO-CBD plan CBT-PHM-12-CB2-CB3831 to SLW and CKC. Opinions, interpretations, conclusions and recommendations are those of the authors and are not necessarily endorsed by the U.S. Army. NR 83 TC 6 Z9 6 U1 0 U2 13 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1364-5072 EI 1365-2672 J9 J APPL MICROBIOL JI J. Appl. Microbiol. PD DEC PY 2013 VL 115 IS 6 BP 1343 EP 1356 DI 10.1111/jam.12322 PG 14 WC Biotechnology & Applied Microbiology; Microbiology SC Biotechnology & Applied Microbiology; Microbiology GA 251OP UT WOS:000326939800009 PM 23927578 ER PT J AU Freberg, KJ Saling, K Freberg, L AF Freberg, Karen J. Saling, Kristin Freberg, Laura TI Using a Situational Q-Sort to Assess Perceptions of a Food Recall Message as a Function of Delivery via Social, Organizational or Traditional Media SO JOURNAL OF CONTINGENCIES AND CRISIS MANAGEMENT LA English DT Article ID CRISIS AB Behavior in response to a crisis will result from a combination of individual and situational variables. In spite of the increased recognition of the importance of situational variables, a literature and methodological toolkit for the study of situational influences that is comparable with those available for individual variables has not yet emerged. However, the recently developed Riverside Situational Q-sort provides a novel method for quantifying subjective impressions of any situation. This proof-of-concept demonstration asked participants to complete the RSQ in response to an imaginary food crisis situation communicated via one of three message sources (social media, organizational website and traditional media). Results illustrate the potential of this method to provide quantitative evaluations of subjective responses to crisis situations. C1 [Freberg, Karen J.] Univ Louisville, Louisville, KY 40292 USA. [Saling, Kristin] US Mil Acad, Dept Syst Engn, West Point, NY USA. [Freberg, Laura] Calif Polytech State Univ San Luis Obispo, San Luis Obispo, CA 93407 USA. RP Freberg, KJ (reprint author), Univ Louisville, 310 Strickler Hall, Louisville, KY 40292 USA. EM karen.freberg@louisville.edu; kristin.saling@usma.edu; lfreberg@calpoly.edu OI Freberg, Laura/0000-0002-8765-9435 NR 19 TC 0 Z9 0 U1 1 U2 14 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0966-0879 EI 1468-5973 J9 J CONTING CRISIS MAN JI J. Cont. Crisis Manag. PD DEC PY 2013 VL 21 IS 4 BP 225 EP 230 DI 10.1111/1468-5973.12026 PG 6 WC Management SC Business & Economics GA 248NL UT WOS:000326707000006 ER PT J AU Das, NC Reed, ML Sampath, AV Shen, H Wraback, M Farrell, RM Iza, M Cruz, SC Lang, JR Young, NG Terao, Y Neufeld, CJ Keller, S Nakamura, S Denbaars, SP Mishra, UK Speck, JS AF Das, N. C. Reed, M. L. Sampath, A. V. Shen, H. Wraback, M. Farrell, R. M. Iza, M. Cruz, S. C. Lang, J. R. Young, N. G. Terao, Y. Neufeld, C. J. Keller, S. Nakamura, S. Denbaars, S. P. Mishra, U. K. Speck, J. S. TI Optimization of Annealing Process for Improved InGaN Solar Cell Performance SO JOURNAL OF ELECTRONIC MATERIALS LA English DT Article DE Solar cell; annealing; InGaN QW; open-circuit voltage ID MG-DOPED GAN; P-TYPE GAN; LIGHT-EMITTING-DIODES; ACTIVATION; OXYGEN; FILMS AB We report enhanced performance of InGaN solar cells grown by metalorganic chemical vapor deposition through optimization of the annealing of the epitaxial wafer before device fabrication. We varied the annealing environment gas mixtures as well as temperatures to obtain the optimized annealing condition. It was found that the major improvement of the nitride solar cell efficiency after annealing is in the increase of the V (oc). In addition, annealing at the reasonably moderate temperature of 550A degrees C in O-2 environment results in the highest-efficiency InGaN solar cell devices compared with devices annealed at different temperatures and in different gas environments. C1 [Das, N. C.; Reed, M. L.; Sampath, A. V.; Shen, H.; Wraback, M.] US Army Res Lab, RDRL SEE M, Adelphi, MD 20783 USA. [Farrell, R. M.; Iza, M.; Cruz, S. C.; Lang, J. R.; Young, N. G.; Terao, Y.; Nakamura, S.; Denbaars, S. P.; Speck, J. S.] Univ Calif Santa Barbara, Dept Mat, Santa Barbara, CA 93106 USA. [Neufeld, C. J.; Keller, S.; Nakamura, S.; Denbaars, S. P.; Mishra, U. K.] Univ Calif Santa Barbara, Dept Elect & Comp Engn, Santa Barbara, CA 93106 USA. RP Das, NC (reprint author), US Army Res Lab, RDRL SEE M, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM naresh.c.das2.civ@mail.mil NR 18 TC 1 Z9 1 U1 0 U2 38 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0361-5235 EI 1543-186X J9 J ELECTRON MATER JI J. Electron. Mater. PD DEC PY 2013 VL 42 IS 12 BP 3467 EP 3470 DI 10.1007/s11664-013-2794-6 PG 4 WC Engineering, Electrical & Electronic; Materials Science, Multidisciplinary; Physics, Applied SC Engineering; Materials Science; Physics GA 248KA UT WOS:000326697100015 ER PT J AU Del Favero, G Beltramo, D Sciancalepore, M Lorenzon, P Coslovich, T Poli, M Testai, E Sosa, S Tubaro, A AF Del Favero, Giorgia Beltramo, Dario Sciancalepore, Marina Lorenzon, Paola Coslovich, Tamara Poli, Mark Testai, Emanuela Sosa, Silvio Tubaro, Aurelia TI Toxicity of palytoxin after repeated oral exposure in mice and in vitro effects on cardiomyocytes SO TOXICON LA English DT Article DE Palytoxin; Repeated dose toxicity; Oral administration; Mice; Cardiomyocytes ID DINOFLAGELLATE OSTREOPSIS-SIAMENSIS; OF-THE-ART; PRIMARY CULTURES; PUMP LIGANDS; ION CHANNELS; MUSCLE-CELLS; MARINE TOXIN; NA+/K+-PUMP; OSTREOCIN-D; SEQUESTRATION AB Palytoxin (PLTX) is a highly toxic hydrophilic polyether detected in several edible marine organisms from intra-tropical areas, where seafood poisoning were reported. Symptoms usually start with gastro-intestinal malaise, often accompanied by myalgia, muscular cramps, dyspnea and, sometimes, arrhythmias. Monitoring programs in the Mediterranean Sea have detected PLTX-like molecules in edible mollusks and echinoderms. Despite the potential exposure of the human population and its high toxic potential, the toxicological profile of the molecule is still an issue. Thus, the effects of repeated oral administration of PLTX in mice were investigated. Seven days of PLTX administration caused lethality and toxic effects at doses >= 30 mu g/kg/day. A NOAEL was estimated equal to 3 mu g/kg/day, indicating a quite steep dose-response curve. This value, due to the limited number of animal tested, is provisional, although represents a sound basis for further testing. Macroscopic alterations at gastrointestinal level (gastric ulcers and intestinal fluid accumulation) were observed in mice dead during the treatment period. Histological analysis highlighted severe inflammation, locally associated with necrosis, at pulmonary level, as well as hypereosinophilia and fiber separation in myocardium. A cardiac damage was supported by the in vitro effect of the toxin on cardiomyocytes, indicating a severe and irreversible impairment of their electrical properties: electrophysiological recordings detected a progressive cell depolarization, arrest of action potentials and beating. (C) 2013 Elsevier Ltd. All rights reserved. C1 [Del Favero, Giorgia; Sciancalepore, Marina; Lorenzon, Paola; Coslovich, Tamara; Sosa, Silvio; Tubaro, Aurelia] Univ Trieste, Dept Life Sci, I-34127 Trieste, Italy. [Beltramo, Dario] Ist Ric Biomed Antoine Marxer RBM SpA, I-10010 Colleretto Giacosa, TO, Italy. [Poli, Mark] US Army Med Res Inst Infect Dis, Ft Detrick, MD 21701 USA. [Testai, Emanuela] Ist Super Sanita, Environm & Primary Prevent Dept, Mech Tox Unit, I-00161 Rome, Italy. RP Sosa, S (reprint author), Univ Trieste, Dept Life Sci, I-34127 Trieste, Italy. EM silvio.sosa@econ.units.it FU Italian Ministry of Education, University and Research [PRIN 2009JS5YX9_002] FX This work was supported by the Italian Ministry of Education, University and Research (PRIN 2009JS5YX9_002). NR 50 TC 7 Z9 7 U1 2 U2 28 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0041-0101 J9 TOXICON JI Toxicon PD DEC 1 PY 2013 VL 75 SI SI BP 3 EP 15 DI 10.1016/j.toxicon.2013.06.003 PG 13 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA 247HY UT WOS:000326609700002 PM 23770425 ER PT J AU Tubaro, A Del Favero, G Beltramo, D Lorenzon, P Sciancalepore, M Florio, C Poli, M Sosa, S AF Tubaro, A. Del Favero, G. Beltramo, D. Lorenzon, P. Sciancalepore, M. Florio, C. Poli, M. Sosa, S. TI Toxicological effects of palytoxins: An integrated in vivo and in vitro approach SO TOXICON LA English DT Meeting Abstract CT 20th Meeting of the French-Society-of-Toxinology (SFET) CY DEC 10-11, 2012 CL Inst Pasteur, Paris, FRANCE SP French Soc Toxinol HO Inst Pasteur C1 [Tubaro, A.; Del Favero, G.; Lorenzon, P.; Sciancalepore, M.; Florio, C.; Sosa, S.] Univ Trieste, Dept Life Sci, I-34127 Trieste, Italy. [Beltramo, D.] Ist Ric Biomed A Marxer RBM SpA, I-10010 Colleretto Giacosa, TO, Italy. [Poli, M.] US Army Med Res Inst Infect Dis, Ft Detrick, MD 21701 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0041-0101 J9 TOXICON JI Toxicon PD DEC 1 PY 2013 VL 75 SI SI BP 210 EP 210 DI 10.1016/j.toxicon.2013.08.017 PG 1 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA 247HY UT WOS:000326609700034 ER PT J AU Wieczorek, L Brown, BK Macedo, CD Wesberry-Schmierer, M Ngauy, V Borges, AR Michael, NL Marovich, MA Montefiori, DC Polonis, VR AF Wieczorek, Lindsay Brown, Bruce K. Macedo, Camila DelSarto Wesberry-Schmierer, Maggie Ngauy, Viseth Borges, Andrew Rosa Michael, Nelson L. Marovich, Mary A. Montefiori, David C. Polonis, Victoria R. TI Mitigation of variation observed in a peripheral blood mononuclear cell (PBMC) based HIV-1 neutralization assay by donor cell pooling SO VIROLOGY LA English DT Article DE HIV-1 neutralization; Peripheral blood mononuclear cells; PBMC targets; Infectious molecular clones; Primary isolates; Monoclonal antibodies; Standardization ID IMMUNODEFICIENCY-VIRUS TYPE-1; MONOCLONAL-ANTIBODIES; IN-VITRO; DIFFERENTIAL SUSCEPTIBILITY; ENVELOPE GLYCOPROTEIN; VACCINE DEVELOPMENT; MOLECULAR CLONES; BETA-CHEMOKINES; CHIMERIC VIRUS; ENV CLONES AB Cultured primary peripheral blood mononuclear cells (PBMC) represent a potentially physiologic in vitro model of HIV-1 infection, but assessment of antibody-mediated HIV-1 neutralization using PBMC has been hindered by donor variability and lack of a sustainable individual PBMC source. To advance this model for HIV vaccine evaluation, intra- and inter-assay variability were assessed using monoclonal and polyclonal antibodies and PBMC targets from multiple HIV-seronegative donors. Inter-assay variability was introduced by using different PBMC for virus propagation, and more substantially, for assay targets. Neutralization titers varied by as much as 4 logs when using different individual donor PBMC as targets; variability was antibody-specific, with the greatest variation observed using an individual polyclonal plasma. Pooling of multiple PBMC donors significantly reduced median inter-assay variation to the level of intra-assay variation, suggesting a pathway forward for establishing a uniform, sustainable and standardized approach to the assessment of antibody function using a PBMC model. Published by Elsevier Inc. C1 [Wieczorek, Lindsay; Brown, Bruce K.; Macedo, Camila DelSarto; Wesberry-Schmierer, Maggie; Ngauy, Viseth; Borges, Andrew Rosa; Michael, Nelson L.; Marovich, Mary A.; Polonis, Victoria R.] Mil HIV Res Program, Silver Spring, MD USA. [Wieczorek, Lindsay; Brown, Bruce K.; Macedo, Camila DelSarto; Wesberry-Schmierer, Maggie; Borges, Andrew Rosa] Henry M Jackson Fdn, Bethesda, MD USA. [Ngauy, Viseth] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Michael, Nelson L.; Marovich, Mary A.; Polonis, Victoria R.] Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. [Montefiori, David C.] Duke Univ, Durham, NC USA. RP Polonis, VR (reprint author), Walter Reed Army Inst Res, MHRP, 503 Robert Grant Ave,Room 1A12, Silver Spring, MD 20910 USA. EM vpolonis@hivresearch.org FU Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. [W81XWH-07-2-0067]; U.S. Department of Defense (DOD) (U.S. Army Medical Research and Material Command) [W81XWH-07-2-0067] FX This work was supported by a cooperative agreement (W81XWH-07-2-0067) between the Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., and the U.S. Department of Defense (DOD) (U.S. Army Medical Research and Material Command), working together with the Division of AIDS, National Institute for Allergy and Infectious Diseases National Institutes of Health. The views expressed here are the private opinions of the authors and are not to be considered as official or reflecting the views of the U.S. Army, the U.S. Department of Defense, or the U.S. Government. Use of trade names is for identification only and does not imply endorsement by the U.S. government. NR 59 TC 0 Z9 0 U1 0 U2 9 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0042-6822 J9 VIROLOGY JI Virology PD DEC PY 2013 VL 447 IS 1-2 BP 240 EP 248 DI 10.1016/j.virol.2013.09.014 PG 9 WC Virology SC Virology GA 246QF UT WOS:000326553500027 PM 24210120 ER PT J AU Childs, T AF Childs, Tammy TI Use of Double Gloving to Reduce Surgical Personnel's Risk of Exposure to Bloodborne Pathogens: An Integrative Review SO AORN JOURNAL LA English DT Review DE gloves; double gloving; single gloving; glove perforations; bloodborne pathogen exposure; percutaneous injury AB Surgical team members are known to have a higher incidence of percutaneous injuries compared with other health care workers, which increases surgical personnel's risk both of exposure to bloodborne pathogens and acquiring bloodborne illnesses. The purpose of this integrative review was to determine whether double gloving reduces the surgical team member's risk of percutaneous injury when compared with single gloving. Factors addressed are double gloving versus single gloving, use of an indicator glove system, optimum levels of protection, and policies and procedures to facilitate compliance with double gloving. Evidence supports the use of double gloving and double gloving with an indicator glove system to decrease the risk of percutaneous injury and therefore is an effective barrier to bloodborne pathogen exposure. Perioperative managers and educators should develop educational methods to support double gloving compliance; monitor and conduct periodic audits to evaluate compliance; and review and revise quality improvement strategies as necessary to protect surgical employees from percutaneous injuries. AORN J 98 (December 2013) 586-593. Published by Elsevier, Inc., on behalf of AORN, Inc. http://dx.doi.org/10.1016/j.aorn.2013.10.004 C1 [Childs, Tammy] Brooke Army Med Ctr, San Antonio, TX USA. [Childs, Tammy] Uniformed Serv Univ Hlth Sci, Perioperat Clin Nurse Specialist Program, Bethesda, MD 20814 USA. RP Childs, T (reprint author), Brooke Army Med Ctr, San Antonio, TX USA. NR 20 TC 2 Z9 2 U1 1 U2 2 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0001-2092 J9 ASSOC OPER ROOM NURS JI AORN J. PD DEC PY 2013 VL 98 IS 6 BP 585 EP + DI 10.1016/j.aorn.2013.10.004 PG 18 WC Nursing SC Nursing GA V42YC UT WOS:000209648100006 PM 24266931 ER PT J AU Darling, RS Phan, MQ Ketcham, SA AF Darling, Richard S. Phan, Minh Q. Ketcham, Stephen A. TI State-space Modeling of Large Domain Wave Propagation Systems by Partitioned C-matrices SO JOURNAL OF THE ASTRONAUTICAL SCIENCES LA English DT Article DE State-space; Modeling; Large -domain; Wave-propagation; C-matrix; Reduced-order AB Reduced-order models represent an enabling technology in the representation of large-scale dynamic systems. This technology often involves identification of linear state-space models with system matrix A, input matrix B, and output matrix C. Our focus is partitioned C-matrices that facilitate creation of reduced-order discrete time state-space models appropriate for simulation of large-output wave propagation systems. The Cy-partition method, used to generate the partitioned C-matrices, is suitable when the output dimension is orders of magnitude higher than the number of discrete time samples specifying the time duration of interest. The resulting state-space model is characterized by a relatively small C-matrix component relating a small number of "anchored" or basis outputs to the inputs, and a large C-matrix component relating all remaining outputs to the anchored outputs. The partitioned C-matrix and the associated A, B matrices can be identified from input-output data directly using time-domain signals, without the necessity of identifying or computing transfer functions. The resulting models can be used for accurate and rapid prediction of wave-field responses. The theory is general for modeling short-duration dynamics and the applications include modeling of vibrations propagating through a large flexible structure (for damage assessment for example). C1 [Darling, Richard S.; Ketcham, Stephen A.] US Army Engineer Res & Dev Ctr, Signature Phys Branch, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. [Phan, Minh Q.] Dartmouth Coll, Thayer Sch Engn, 14 Engn Dr, Hanover, NH 03755 USA. RP Phan, MQ (reprint author), Dartmouth Coll, Thayer Sch Engn, 14 Engn Dr, Hanover, NH 03755 USA. EM minh.q.phan@dartmouth.edu FU Enhanced Linear Sensors for Persistent Intelligence, Surveillance, and Reconnaissance project; U.S. Department of the Army FX This study was in support of the Enhanced Linear Sensors for Persistent Intelligence, Surveillance, and Reconnaissance project performed at the U.S. Army Engineer Research and Development Center. Computational support was from the U.S. Department of Defense High Performance Computing Modernization Program. Support to Thayer School at Dartmouth was from a Small Business Technology Transfer grant by the U.S. Department of the Army. NR 16 TC 0 Z9 0 U1 1 U2 1 PU AMER ASTRONAUTICAL SOC PI SPRINGFIELD PA 6352 ROLLING MILL PLACE SUITE 102, SPRINGFIELD, VA 22152 USA SN 0021-9142 EI 2195-0571 J9 J ASTRONAUT SCI JI J. Astronaut. Sci. PD DEC PY 2013 VL 60 IS 3-4 BP 541 EP 558 DI 10.1007/00295-015-0069-6 PG 18 WC Engineering, Aerospace SC Engineering GA V41VW UT WOS:000209574700015 ER PT J AU Ketcham, SA Phan, MQ Darling, RS McKenna, MH AF Ketcham, Stephen A. Phan, Minh Q. Darling, Richard S. McKenna, Mihan H. TI Realization of State-Space Models for Wave Propagation Simulations SO JOURNAL OF THE ASTRONAUTICAL SCIENCES LA English DT Article DE Superstable; State space; Identification; Realization; Infrasound; Propagation; Supercomputer; Wave field; Simulations; Pulse response; Reduced order model AB Fully three-dimensional numerical solutions can quantify exterior seismic or acoustic propagation throughout complex geologic or atmospheric domains. Results from impulsive sources typically reveal propagating waves plus reverberations due to multi-path scattering and wave-guide behavior, with decay toward quiescent motions as the dominant wave energy moves out of the domain. Because such computations are expensive and yield large data sets, it is advantageous to make the data reusable and reducible for both direct and reciprocal simulations. Our objective is efficient time-domain simulation of the wave-field response to sources with arbitrary time series. For this purpose we developed a practical and robust technique for superstable model identification. A superstable model has the form of a state-space model, but the output matrix contains the system dynamics. It simulates propagation with the fidelity of the pulse response calculated for the numerical system. Our development of the superstable technique was motivated by our initial application of the Eigensystem Realization Algorithm to wave-field systems from high-performance-computing analyses, where we recognized exterior propagation features allowing superstable model assignment. Most importantly the pulse response and its decay over the domain are captured in a finite duration, and decay to zero beyond a finite number of time steps implies a system with zero eigenvalues. We review the superstable identification technique and demonstrate in detail infrasonic propagation system identification with pulse response data derived from supercomputer analysis. We conclude that, using superstable-identified systems, we are able to create reusable and reducible propagation-system models that accurately simulate the wave field using a fraction of the original computational resources. C1 [Ketcham, Stephen A.; Darling, Richard S.] US Army Engineer Res & Dev Ctr, Signature Phys Branch, Cold Reg Res & Engn Lab, 72 Lyme Rd, Hanover, NH 03755 USA. [Phan, Minh Q.] Dartmouth Coll, Thayer Sch Engn, Hanover, NH 03755 USA. [McKenna, Mihan H.] US Army Engineer Res & Dev Ctr, Geotech & Struct Lab, Vicksburg, MS 39180 USA. RP Ketcham, SA (reprint author), US Army Engineer Res & Dev Ctr, Signature Phys Branch, Cold Reg Res & Engn Lab, 72 Lyme Rd, Hanover, NH 03755 USA. EM Stephen.A.Ketcham@usace.army.mil FU "Denied Area Monitoring Using Infrasound" project; U.S. Department of the Army FX This study was in support of the "Denied Area Monitoring Using Infrasound" project performed for the Center Directed Research Initiative at the U.S. Army Engineer Research and Development Center. Computational support was from the U.S. Department of Defense High Performance Computing Modernization Program. Support to Thayer School at Dartmouth was from a Small Business Technology Transfer grant by the U.S. Department of the Army. NR 10 TC 0 Z9 0 U1 0 U2 0 PU AMER ASTRONAUTICAL SOC PI SPRINGFIELD PA 6352 ROLLING MILL PLACE SUITE 102, SPRINGFIELD, VA 22152 USA SN 0021-9142 EI 2195-0571 J9 J ASTRONAUT SCI JI J. Astronaut. Sci. PD DEC PY 2013 VL 60 IS 3-4 BP 607 EP 622 DI 10.1007/s40295-015-0060-2 PG 16 WC Engineering, Aerospace SC Engineering GA V41VW UT WOS:000209574700018 ER PT J AU Lin, P Phan, MQ Ketcham, SA AF Lin, Ping Phan, Minh Q. Ketcham, Stephen A. TI Batch-Form Solutions to Optimal Input Signal Recovery in the Presence of Noises SO JOURNAL OF THE ASTRONAUTICAL SCIENCES LA English DT Article DE Input identification; OKID; ARX model; Unit pulse response model; Short-duration large-domain signal recovery AB This paper studies the problem of optimally recovering the input signals to a linear time-invariant system in the presence of input and measurement noises. The emphasis is on batch-form solutions which are suitable for short-duration large domain signal propagation applications. The system, the input and measurement noise covariances, the noise-corrupted output signals are assumed known, and we seek to recover the input signals that enter the system prior to being corrupted by input noise. The input signal recovery is optimal in the sense that the optimal Kalman filter residual is correctly recovered from the given information. Various solution techniques are considered and a weighted least-squares solution is found to be the simplest and most practical in short-duration signal recovery applications. C1 [Lin, Ping; Phan, Minh Q.] Dartmouth Coll, Thayer Sch Engn, Hanover, NH 03755 USA. [Ketcham, Stephen A.] US Army Engineer Res & Dev Ctr, Signature Phys Branch, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. RP Phan, MQ (reprint author), Dartmouth Coll, Thayer Sch Engn, Hanover, NH 03755 USA. EM minh.q.phan@dartmouth.edu NR 16 TC 0 Z9 0 U1 0 U2 0 PU AMER ASTRONAUTICAL SOC PI SPRINGFIELD PA 6352 ROLLING MILL PLACE SUITE 102, SPRINGFIELD, VA 22152 USA SN 0021-9142 EI 2195-0571 J9 J ASTRONAUT SCI JI J. Astronaut. Sci. PD DEC PY 2013 VL 60 IS 3-4 BP 654 EP 671 DI 10.1007/s40295-015-0063-z PG 18 WC Engineering, Aerospace SC Engineering GA V41VW UT WOS:000209574700020 ER PT J AU Moore, NLT Altman, DE Gauchan, S Genovese, RF AF Moore, Nicole L. T. Altman, Daniel E. Gauchan, Sangeeta Genovese, Raymond F. TI Different Adolescent Traumatic Stress Pre-exposures Differentially Modify Adulthood Predator Stress Responses in Rats SO NEUROPSYCHOPHARMACOLOGY LA English DT Meeting Abstract DE stress; underwater; predator; adolescence; behavior C1 [Moore, Nicole L. T.; Altman, Daniel E.; Gauchan, Sangeeta; Genovese, Raymond F.] Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU NATURE PUBLISHING GROUP PI LONDON PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND SN 0893-133X EI 1740-634X J9 NEUROPSYCHOPHARMACOL JI Neuropsychopharmacology PD DEC PY 2013 VL 38 SU 2 MA T6 BP S275 EP S276 PG 2 WC Neurosciences; Pharmacology & Pharmacy; Psychiatry SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry GA V40KI UT WOS:000209477100452 ER PT J AU Samet, ED AF Samet, Elizabeth D. TI Make Movies, Not War SO RARITAN-A QUARTERLY REVIEW LA English DT Article C1 US Mil Acad, West Point, NY 10996 USA. RP Samet, ED (reprint author), US Mil Acad, West Point, NY 10996 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU RARITAN-A QUARTERLY REVIEW PI NEW BRUNSWICK PA RUTGERS UNIV, 31 MINE ST, NEW BRUNSWICK, NJ 08903 USA SN 0275-1607 J9 RARITAN JI Raritan-Q. Rev. PD WIN PY 2013 VL 32 IS 3 BP 77 EP 100 PG 24 WC Literary Reviews SC Literature GA AX0CP UT WOS:000346621400006 ER PT J AU Das, U Singh, RSP Alcorn, J Hickman, MR Sciotti, RJ Leed, SE Lee, PJ Roncal, N Dimmock, JR AF Das, Umashankar Singh, Ravi S. P. Alcorn, Jane Hickman, Mark R. Sciotti, Richard J. Leed, Susan E. Lee, Patricia J. Roncal, Norma Dimmock, Jonathan R. TI 3,5-Bis(benzylidene)-4-piperidones and related N-acyl analogs: A novel cluster of antimalarials targeting the liver stage of Plasmodium falciparum SO BIOORGANIC & MEDICINAL CHEMISTRY LA English DT Article DE Antimalarials; 3,5-Bis(benzylidene)-4-piperidones; Plasmodium falciparum; Plasmodium berghei; Drug resistance; Stability; Permeability ID IN-VITRO; REDUCTASE; DESIGN; ASSAY AB Drug resistance is a major challenge in antimalarial chemotherapy. In addition, a complete cure of malaria requires intervention at various stages in the development of the parasite within the host. There are only a few antimalarials that target the liver stage of the Plasmodium species which is an essential part of the life cycle of the malarial parasite. We report a series of antimalarial 3,5-bis(benzylidene)-4-piperidones and related N-acyl analogs 1-5, a number of which exhibit potent in vitro growth-inhibiting properties towards drug-sensitive D6 and drug-resistant C235 strains of Plasmodium falciparum as well as inhibiting the liver stage development of the malarial life cycle. The compounds 2b (IC50: 165 ng/mL), 3b (IC50: 186 ng/mL), 5c (IC50: 159 ng/mL) and 5d (IC50: 93.5 ng/mL) emerged as lead molecules that inhibit liver stage Plasmodium berghei and are significantly more potent than chloroquine (IC50: >2000 ng/mL) and mefloquine (IC50: >2000 ng/mL) in this screen. All the compounds that showed potent inhibitory activity against the P. berghei liver stage were nontoxic to human HepG2 liver cells (IC50: >2000 ng/mL). The compounds 5a and 5b exhibit comparable metabolic stability as chloroquine and mefloquine in human plasma and the most potent compound 5d demonstrated suitable permeability characteristics using the MDCK monolayer. These results emphasize the value of 3,5-bis(benzylidene)-4-piperidones as novel antimalarials for further drug development. (C) 2013 Elsevier Ltd. All rights reserved. C1 [Das, Umashankar; Singh, Ravi S. P.; Alcorn, Jane; Dimmock, Jonathan R.] Univ Saskatchewan, Coll Pharm & Nutr, Drug Discovery & Dev Res Grp, Saskatoon, SK S7N 5C9, Canada. [Hickman, Mark R.; Sciotti, Richard J.; Leed, Susan E.; Lee, Patricia J.; Roncal, Norma] Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD 20910 USA. RP Das, U (reprint author), Univ Saskatchewan, Coll Pharm & Nutr, Drug Discovery & Dev Res Grp, Saskatoon, SK S7N 5C9, Canada. EM umashankar.das@usask.ca; jr.dimmock@usask.ca RI Singh, Ravi Shankar /L-9408-2014 OI Singh, Ravi Shankar /0000-0001-6298-8219 FU Canadian Institutes of Health Research [ROP-53171]; College of Graduate Studies and Research at the University of Saskatchewan FX The authors thank the Canadian Institutes of Health Research for a Grant (ROP-53171) in support of this work and the College of Graduate Studies and Research at the University of Saskatchewan for providing a Dean's scholarship to R. S. P. Singh. The permeability and metabolic stability experiments were undertaken by the Department of Development, Division of Experimental Therapeutics, Walter Reed Army Institute of Research, Silver Spring, MD, USA. The opinions of the staff of the Walter Reed Army Institute of Research (WRAIR) represent their own views and do not constitute the official views of WRAIR, the US Army or the Department of Defense. NR 19 TC 1 Z9 1 U1 0 U2 8 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0968-0896 EI 1464-3391 J9 BIOORGAN MED CHEM JI Bioorg. Med. Chem. PD DEC 1 PY 2013 VL 21 IS 23 BP 7250 EP 7256 DI 10.1016/j.bmc.2013.09.065 PG 7 WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Chemistry, Organic SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Chemistry GA 244GF UT WOS:000326374600002 PM 24139941 ER PT J AU Lindsay, DL Jung, MG Lance, RF AF Lindsay, Denise L. Jung, Michael G. Lance, Richard F. TI Novel microsatellite loci to investigate population structure in the endangered gray bat (Myotis grisescens) SO CONSERVATION GENETICS RESOURCES LA English DT Article DE Myotis grisecens; Gray bat; Microsatellites ID WINDOWS; LINUX AB We isolated and characterized 16 polymorphic microsatellite loci in the endangered gray bat (Myotis grisescens). This set of loci will be used to investigate patterns of genetic structure in hibernacula and maternity colonies of the gray bat across their range, ultimately combining multiple lines of evidence (mtDNA data, stable isotope signatures, etc.) to develop a spatial network for the species. C1 [Lindsay, Denise L.; Jung, Michael G.; Lance, Richard F.] US Army Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA. RP Lindsay, DL (reprint author), US Army Engineer Res & Dev Ctr, Environm Lab, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM denise.l.lindsay@usace.army.mil NR 10 TC 0 Z9 0 U1 4 U2 21 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 1877-7252 EI 1877-7260 J9 CONSERV GENET RESOUR JI Conserv. Genet. Resour. PD DEC PY 2013 VL 5 IS 4 BP 1055 EP 1057 DI 10.1007/s12686-013-9969-6 PG 3 WC Biodiversity Conservation; Genetics & Heredity SC Biodiversity & Conservation; Genetics & Heredity GA 244KS UT WOS:000326387800039 ER PT J AU Brown, R Pusey, J Murugan, M Le, D AF Brown, Ross Pusey, Jason Murugan, Muthuvel Le, Dy TI Generalized predictive control algorithm of a simplified ground vehicle suspension system SO JOURNAL OF VIBRATION AND CONTROL LA English DT Article DE Adaptive suspension control; generalized predictive controller; preview control; vibration control ID PREVIEW CONTROL AB This paper discusses research conducted by the Army Research Laboratory (ARL)-Vehicle Technology Directorate (VTD) on advanced suspension control. ARL-VTD has conducted research on advanced suspension systems that will reduce the chassis vibration of ground vehicles while maintaining tire contact with the road surface. The purpose of this research is to reduce vibration-induced fatigue to the Warfighter as well as to improve the target aiming precision in-theater. The objective of this paper was to explore the performance effectiveness of various formulations of the generalized predictive control algorithm in a simulation environment. Each version of the control algorithm was applied to an identical model subjected to the same ground disturbance input and compared to a baseline passive suspension system. The control algorithms considered include a generalized predictive controller (GPC) with implicit disturbances, GPC with explicit disturbances, and GPC with preview control. The suspension model used was a two-degree-of-freedom dof quarter-car model with a given set of vehicle parameters. The performance of the control algorithms were compared based on their effectiveness in controlling peak acceleration and overall average acceleration over a range of vehicle speeds. The algorithms demonstrated significant reductions in the chassis acceleration of the quarter-car model. C1 [Brown, Ross; Pusey, Jason; Murugan, Muthuvel; Le, Dy] US Army, Res Lab, Vehicle Technol Directorate, Aberdeen Proving Ground, MD 21005 USA. RP Murugan, M (reprint author), US Army, Res Lab, Vehicle Technol Directorate, Aberdeen Proving Ground, MD 21005 USA. EM muthuvel.murugan.civ@mail.mil NR 8 TC 3 Z9 3 U1 4 U2 14 PU SAGE PUBLICATIONS LTD PI LONDON PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND SN 1077-5463 EI 1741-2986 J9 J VIB CONTROL JI J. Vib. Control PD DEC PY 2013 VL 19 IS 16 BP 2372 EP 2386 DI 10.1177/1077546312448505 PG 15 WC Acoustics; Engineering, Mechanical; Mechanics SC Acoustics; Engineering; Mechanics GA 244FD UT WOS:000326371600005 ER PT J AU Petersen, E Yang, ZY Satyan, N Vasilyev, A Rakuljic, G Yariv, A White, JO AF Petersen, Eliot Yang, Zhi Yi Satyan, Naresh Vasilyev, Arseny Rakuljic, George Yariv, Amnon White, Jeffrey O. TI Stimulated Brillouin Scattering Suppression With a Chirped Laser Seed: Comparison of Dynamical Model to Experimental Data SO IEEE JOURNAL OF QUANTUM ELECTRONICS LA English DT Article DE Brillouin scattering; chirped lasers; fiber amplifiers; numerical simulation ID DOPED FIBER AMPLIFIERS; OPTICAL-FIBERS; SBS-THRESHOLD; PHASE; BAND; LOCKING AB A numerical model is developed to simulate stimulated Brillouin scattering (SBS) in high power single-mode fiber amplifiers. The time dependent model incorporates both laser and Stokes wave amplification and initiates the Brillouin scattering from thermal phonons. A frequency chirped laser is used as the seed to suppress SBS. Experiments with Yb-doped fiber amplifiers show good agreement with the modeling. Using experimentally determined parameters, the model is used to predict chirp requirements for multi-kilowatt amplifiers with tens of meters of delivery fiber. A comparison is made between a chirped seed source and random phase modulation for SBS suppression. C1 [Petersen, Eliot; Yang, Zhi Yi; White, Jeffrey O.] US Army, Res Lab, Adelphi, MD 20783 USA. [Satyan, Naresh; Vasilyev, Arseny; Yariv, Amnon] CALTECH, Dept Appl Phys & Mat Sci, Pasadena, CA 91125 USA. [Rakuljic, George] Telaris Inc, Santa Monica, CA 90403 USA. RP Petersen, E (reprint author), US Army, Res Lab, Adelphi, MD 20783 USA. EM eliot.petersen.ctr@mail.mil; Zhi.Y.Yang.ctr@us.army.mil; naresh@caltech.edu; vasilyev@caltech.edu; rakuljic@telarisinc.com; ayariv@caltech.edu; jeffrey.o.white6.civ@mail.mil FU High Energy Laser Joint Technology Office [11-SA-0405, SA-13-0509] FX Manuscript received July 15, 2013; revised September 29, 2013; accepted October 8, 2013. Date of publication October 10, 2013; date of current version October 23, 2013. This work was supported by High Energy Laser Joint Technology Office under Grants 11-SA-0405 and SA-13-0509. NR 16 TC 9 Z9 9 U1 0 U2 21 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0018-9197 EI 1558-1713 J9 IEEE J QUANTUM ELECT JI IEEE J. Quantum Electron. PD DEC PY 2013 VL 49 IS 12 BP 1040 EP 1044 DI 10.1109/JQE.2013.2285489 PG 5 WC Engineering, Electrical & Electronic; Optics; Physics, Applied SC Engineering; Optics; Physics GA 242ND UT WOS:000326248100006 ER PT J AU Lin-Hurtubise, KM Yheulon, CG Gagliano, RA Lynch, HT AF Lin-Hurtubise, Kevin M. Yheulon, Christopher G. Gagliano, Ronald A., Jr. Lynch, Henry T. TI Excess of Extracolonic Non-Endometrial Multiple Primary Cancers in MSH2 Germline Mutation Carriers Over MLH1 SO JOURNAL OF SURGICAL ONCOLOGY LA English DT Article DE HNPCC; lynch syndrome; MLH1; MSH2; urinary tract ID NONPOLYPOSIS COLORECTAL-CANCER; REVISED BETHESDA GUIDELINES; LYNCH-SYNDROME; MICROSATELLITE INSTABILITY; COST-EFFECTIVENESS; TUMOR SPECTRUM; COLON-CANCER; SURVIVAL; RISK; IMMUNOHISTOCHEMISTRY AB BackgroundThe lynch syndrome (LS) tumor spectrum involves colorectal cancer (CRC), endometrial cancer (EC), and less frequently various extracolonic non-endometrial cancers (non-EC). The organ-specific survival rates of these patients are well defined, however, the collective survival of all-cancers combined (CRC+EC+non-EC) are unclear. MethodsFifty-two MSH2 patients and 68 MLH1 patients were followed for a median of 6.3 years after diagnosis of first cancer, regardless of type. The proportions of CRC only, EC, non-EC, and multiple primary cancers were compared between the two genotypes. Kaplan-Meier curves were developed for survival comparisons. ResultsMSH2 patients present less frequently with only CRC (37% MSH2, 62% MLH1, P=0.0096), manifest more multiple primary cancers (38% MSH2, 18% MLH1, P=0.013), develop more extracolonic cancers (62% MSH2, 38% MLH1, P=0.003), non-EC only cancers (46% MSH2, 24% MLH1, P=0.028) and carry a greater risk for urinary tract cancer (UTC) (13.4% MSH2, 1.5% MLH1, P=0.024). There was no difference in 10-year survival between the two groups (P=0.4). ConclusionThe additional propensity for UTC in MSH2 carriers argues in favor of UTC screening in MSH2 individuals. Other types of cancer screening should be tailored to the expression history of the specific LS mutation. J. Surg. Oncol. 2013; 108:433-437. (c) 2013 Wiley Periodicals, Inc. C1 [Lin-Hurtubise, Kevin M.; Yheulon, Christopher G.; Gagliano, Ronald A., Jr.] Tripler Army Med Ctr, Dept Surg, Honolulu, HI 96859 USA. [Lynch, Henry T.] Creighton Univ, Sch Med, Dept Prevent Med & Publ Hlth, Omaha, NE USA. RP Yheulon, CG (reprint author), Tripler Army Med Ctr, Dept Surg, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM christopher.yheulon@gmail.com NR 33 TC 3 Z9 3 U1 1 U2 7 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0022-4790 EI 1096-9098 J9 J SURG ONCOL JI J. Surg. Oncol. PD DEC PY 2013 VL 108 IS 7 BP 433 EP 437 DI 10.1002/jso.23413 PG 5 WC Oncology; Surgery SC Oncology; Surgery GA 243HT UT WOS:000326308200003 PM 24122742 ER PT J AU Flanagan, R Cain, N Tatum, GH DeBrunner, MG Drant, S Feingold, B AF Flanagan, Ryan Cain, Nicole Tatum, Gregory H. DeBrunner, Mark G. Drant, Stacey Feingold, Brian TI Left ventricular myocardial performance index change for detection of acute cellular rejection in pediatric heart transplantation SO PEDIATRIC TRANSPLANTATION LA English DT Article DE heart transplant; pediatric; acute rejection; myocardial performance index; echocardiogram ID CARDIAC TRANSPLANTATION; ENDOMYOCARDIAL BIOPSY; DILATED CARDIOMYOPATHY; RECIPIENTS; ECHOCARDIOGRAPHY; CHILDREN AB EMB, the gold standard for diagnosis of ACR, poses unique risks in children. Limited cross-sectional data have associated LV MPI with ACR. We hypothesize that a relative change in MPI from baseline without ACR to the time of ACR will better detect ACR than an absolute threshold LV MPI value. We identified 40 children with ACR 60days post-transplant matching them by age and time from transplantation to 40 children without ACR. There was a significant increase in LV MPI at time of ACR vs. baseline (0.59 +/- 0.17 vs. 0.41 +/- 0.11; p<0.001). There was no difference in LV MPI between baseline and follow-up (0.41 +/- 0.11 vs. 0.42 +/- 0.11; p=0.65). An absolute increase in LV MPI of 0.47 had 82.5% sensitivity and 85% specificity for ACR, whereas an increase in LV MPI from baseline of 20.4% was 90% sensitive and 100% specific. Serial measurement of LV MPI appears to be a sensitive and specific marker of ACR. LV MPI shows good interobserver agreement and increases at the time of EMB-proven ACR with subsequent resolution to baseline measurements upon EMB-proven resolution of ACR. Future studies in larger, prospective cohorts should be undertaken to validate these findings. C1 [Flanagan, Ryan; DeBrunner, Mark G.; Drant, Stacey; Feingold, Brian] UPMC, Childrens Hosp Pittsburgh, Div Pediat Cardiol, Pittsburgh, PA 15224 USA. [Cain, Nicole] Med Univ S Carolina, Div Pediat Cardiol, Childrens Hosp, Charleston, SC 29425 USA. [Tatum, Gregory H.] Duke Childrens Hosp & Hlth Ctr, Div Pediat Cardiol, Durham, NC USA. [Feingold, Brian] Univ Pittsburgh, Pittsburgh, PA USA. [Flanagan, Ryan] Womack Army Med Ctr, Ft Bragg, NC USA. RP Feingold, B (reprint author), UPMC, Childrens Hosp Pittsburgh, Div Pediat Cardiol, 4401 Penn Ave, Pittsburgh, PA 15224 USA. EM Brian.Feingold@chp.edu OI Cain, Nicole/0000-0001-5931-9401 FU National Institutes of Health [KL2RR024154, KL2TR000146] FX Dr. Feingold's effort on this project was supported by the National Institutes of Health (KL2RR024154, KL2TR000146). Content is solely the responsibility of the authors and does not necessarily represent the views of the National Institutes of Health. NR 23 TC 3 Z9 3 U1 0 U2 1 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1397-3142 EI 1399-3046 J9 PEDIATR TRANSPLANT JI Pediatr. Transplant. PD DEC PY 2013 VL 17 IS 8 BP 782 EP 786 DI 10.1111/petr.12153 PG 5 WC Pediatrics; Transplantation SC Pediatrics; Transplantation GA 240ET UT WOS:000326078400035 PM 24118848 ER PT J AU Dean, SW Potter, JK Yetter, RA Eden, TJ Champagne, V Trexler, M AF Dean, Steven W. Potter, John K. Yetter, Richard A. Eden, Timothy J. Champagne, Victor Trexler, Matthew TI Energetic intermetallic materials formed by cold spray SO INTERMETALLICS LA English DT Article DE Nickel aluminides; based on NiAl; Thermodynamic and thermochemical; properties; Coatings; intermetallics and otherwise; Reaction synthesis; Calorimetry ID NI-AL SYSTEM; COMBUSTION SYNTHESIS; REACTION-MECHANISM; COATINGS; MICROSTRUCTURE; TEMPERATURE; EXPLOSION; ALUMINIDE; PRESSURE; NICKEL AB Cold spray was used to synthesize three intermetallic energetic materials from powders composed of mixed Ni/Al, mixed Ni/Al/MoO3, and Ni-clad Al. After bulk samples were produced, characterization was performed to determine their composition and reactivity. Ignition was achieved with a 30 W CO2 laser and propagation rates were measured using a high speed digital video camera. Differential scanning calorimetry was used to obtain energetic properties of the composites at slow heating rates. The energetic properties of cold sprayed samples were compared with lower density axially pressed pellets of identical composition. Samples composed of a mechanical blend of Ni and Al powders had higher reaction propagation rates at lower densities; with the near fully-dense cold spray samples having the lowest propagation rates. The opposite was found in samples composed of Ni-clad Al powders, with propagation rate increasing with increasing density for pellets, and reaching a maximum in the cold sprayed samples. The samples containing MoO3 had mixed results, with pellets experiencing higher propagation rates for all MoO3 contents' with increasing density, but cold sprayed samples having lower propagation rates as the MoO3 content increased. (C) 2013 Elsevier Ltd. All rights reserved. C1 [Dean, Steven W.; Yetter, Richard A.] Penn State Univ, Dept Mech & Nucl Engn, University Pk, PA 16802 USA. [Potter, John K.; Eden, Timothy J.] Penn State Univ, Appl Res Lab, University Pk, PA 16802 USA. [Champagne, Victor; Trexler, Matthew] US Army Res Lab, Weap & Mat Res Directorate Aberdeen Proving Groun, Aberdeen, MD 21005 USA. RP Dean, SW (reprint author), Penn State Univ, Dept Mech & Nucl Engn, University Pk, PA 16802 USA. EM swd125@psu.edu FU US Army Research Office under the Multi-University Research Initiative [W911NF-04-1-0178] FX The authors would like to thank the Francis Wolff and Jeremy Schreiber from the Applied Research Laboratory at The Pennsylvania State University for their help in mounting and polishing cold sprayed samples. This work was partially supported by the US Army Research Office under the Multi-University Research Initiative Contract Number W911NF-04-1-0178. NR 30 TC 6 Z9 6 U1 1 U2 30 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0966-9795 EI 1879-0216 J9 INTERMETALLICS JI Intermetallics PD DEC PY 2013 VL 43 BP 121 EP 130 DI 10.1016/j.intermet.2013.07.019 PG 10 WC Chemistry, Physical; Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Chemistry; Materials Science; Metallurgy & Metallurgical Engineering GA 234WR UT WOS:000325675500017 ER PT J AU Huang, LJ Wang, YQ Miao, YY Swenson, D Ma, Y Yen, CF AF Huang, Lejian Wang, Youqi Miao, Yuyang Swenson, Daniel Ma, Ying Yen, Chian-Fong TI Dynamic relaxation approach with periodic boundary conditions in determining the 3-D woven textile micro-geometry SO COMPOSITE STRUCTURES LA English DT Article DE Fabric/textiles; 3-D woven; Textile micro-geometry; Dynamic relaxation; Periodic boundary condition ID INDUSTRIAL PREFORMS; COMPOSITES; MECHANICS AB A dynamic digital element approach, utilizing a dynamic relaxation procedure, is developed to determine 3-D woven textile micro-geometries. Three yarn/tow structures, including plain yarn, twisted yarn, and twisted tow, are generated by the digital element mesh. An explicit algorithm with a periodic boundary condition is employed to calculate nodal forces, accelerations, velocities, and displacements within the unit cell. Because the majority of the computing time is consumed to detect contacts between fibers, an efficient contact search algorithm is proposed. In addition, a multi-level dynamic relaxation procedure is implemented to further reduce computer time. The yarn-level fabric micro-geometry is also generated in a format that can be read by commercial finite element software. The micro-geometries derived from numerical simulations are compared to the microscopic images of actual fabrics. Good agreement is found between numerical results and experimental results. (C) 2013 Elsevier Ltd. All rights reserved. C1 [Huang, Lejian; Wang, Youqi; Miao, Yuyang; Swenson, Daniel; Ma, Ying] Kansas State Univ, Dept Mech & Nucl Engn, Manhattan, KS 66506 USA. [Yen, Chian-Fong] US Army, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Wang, YQ (reprint author), Kansas State Univ, Dept Mech & Nucl Engn, Manhattan, KS 66506 USA. EM youqi@ksu.edu FU US Army Research Laboratory at Aberdeen Proving Ground FX The authors would like to acknowledge the financial support from the US Army Research Laboratory at Aberdeen Proving Ground. NR 16 TC 7 Z9 7 U1 6 U2 17 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0263-8223 EI 1879-1085 J9 COMPOS STRUCT JI Compos. Struct. PD DEC PY 2013 VL 106 BP 417 EP 425 DI 10.1016/j.compstruct.2013.05.057 PG 9 WC Materials Science, Composites SC Materials Science GA 231VY UT WOS:000325447700038 ER PT J AU Nguyen, HV Patel, VM Nasrabadi, NM Chellappa, R AF Hien Van Nguyen Patel, Vishal M. Nasrabadi, Nasser M. Chellappa, Rama TI Design of Non-Linear Kernel Dictionaries for Object Recognition SO IEEE TRANSACTIONS ON IMAGE PROCESSING LA English DT Article DE Kernel methods; dictionary learning; method of optimal directions; KSVD ID SPARSE REPRESENTATION; IMAGE CLASSIFICATION; PATTERN-RECOGNITION; TANGENT DISTANCE; FACE RECOGNITION; K-SVD; APPROXIMATION; PURSUIT AB In this paper, we present dictionary learning methods for sparse signal representations in a high dimensional feature space. Using the kernel method, we describe how the well known dictionary learning approaches, such as the method of optimal directions and KSVD, can be made nonlinear. We analyze their kernel constructions and demonstrate their effectiveness through several experiments on classification problems. It is shown that nonlinear dictionary learning approaches can provide significantly better performance compared with their linear counterparts and kernel principal component analysis, especially when the data is corrupted by different types of degradations. C1 [Hien Van Nguyen] Siemens Corp Res, Princeton, NJ 08540 USA. [Chellappa, Rama] Univ Maryland, Dept Elect & Comp Engn, UMIACS, College Pk, MD 20742 USA. [Patel, Vishal M.; Chellappa, Rama] Univ Maryland, Ctr Automat Res, UMIACS, College Pk, MD 20742 USA. [Nasrabadi, Nasser M.] US Army Res Lab, Adelphi, MD 20783 USA. RP Nguyen, HV (reprint author), Siemens Corp Res, Princeton, NJ 08540 USA. EM hien@umiacs.umd.edu; pvishalm@umiacs.umd.edu; nasser.m.nasrabadi@us.army.mil; rama@umiacs.umd.edu FU MURI from the Army Research Office [W911NF-09-1-0383] FX This work was supported by a MURI from the Army Research Office under Grant W911NF-09-1-0383. The associate editor coordinating the review of this manuscript and approving it for publication was Prof. Vladimir Stankovic. NR 53 TC 39 Z9 40 U1 2 U2 21 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1057-7149 J9 IEEE T IMAGE PROCESS JI IEEE Trans. Image Process. PD DEC PY 2013 VL 22 IS 12 BP 5123 EP 5135 DI 10.1109/TIP.2013.2282078 PG 13 WC Computer Science, Artificial Intelligence; Engineering, Electrical & Electronic SC Computer Science; Engineering GA 228WS UT WOS:000325223300045 PM 24058027 ER PT J AU Hu, WK Wang, YN Yu, J Yen, CF Bobaru, F AF Hu, Wenke Wang, Yenan Yu, Jian Yen, Chian-Fong Bobaru, Florin TI Impact damage on a thin glass plate with a thin polycarbonate backing SO INTERNATIONAL JOURNAL OF IMPACT ENGINEERING LA English DT Article DE Glass; Multi-layer; Brittle fracture; Impact; Peridynamics ID PERIDYNAMIC MODEL; DYNAMIC FRACTURE; STEEL SPHERES; SURFACES; MECHANICS AB We present experimental and computational results for the impact of a spherical projectile on a thin glass plate with a thin polycarbonate backing plate, restrained in a metal frame, or in the absence of the frame. We analyze the dependence of the damage patterns in the glass plate on the increasing impact velocities, from 61 m/s to 200 m/s. Experimental results are compared with those from peridynamic simulations of a simplified model. The main fracture patterns observed experimentally are captured by the peridynamic model for each of the three projectile velocities tested. More accurate implementation of the actual boundary conditions present in the experiments will likely further improve modeling of brittle damage from impact on a multi-layered system. The peridynamic computational model sheds light into the early stages of the complex brittle damage evolution in the glass layer, and the influence of boundary conditions on the dynamic fracture process. (C) 2013 Elsevier Ltd. All rights reserved. C1 [Hu, Wenke; Wang, Yenan; Bobaru, Florin] Univ Nebraska, Dept Mech & Mat Engn, Lincoln, NE 68588 USA. [Yu, Jian; Yen, Chian-Fong] US Army, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Bobaru, F (reprint author), Univ Nebraska, Dept Mech & Mat Engn, Lincoln, NE 68588 USA. EM fbobaru2@unl.edu RI Bobaru, Florin/J-2167-2012 OI Bobaru, Florin/0000-0002-9954-6489 FU UNL; ARO; ARL; ARO [58450 EG]; Callahan Research of New Zeeland FX The authors are thankful for the financial support offered through research contracts between UNL and the ARO (Dr. Larry Russell), and ARL (project coordinators Dr. C.F. Yen), ARO award number 58450 EG. The last author acknowledges partial support from Callahan Research of New Zeeland (project coordinator Dr. Biswajit Banerjee). The computations in this paper have been completed using facilities at the Holland Computing Center of the University of Nebraska-Lincoln. NR 27 TC 23 Z9 23 U1 5 U2 28 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0734-743X J9 INT J IMPACT ENG JI Int. J. Impact Eng. PD DEC PY 2013 VL 62 BP 152 EP 165 DI 10.1016/j.ijimpeng.2013.07.001 PG 14 WC Engineering, Mechanical; Mechanics SC Engineering; Mechanics GA 224OZ UT WOS:000324899300013 ER PT J AU Kotan, H Darling, KA Saber, M Scattergood, RO Koch, CC AF Kotan, Hasan Darling, Kris A. Saber, Mostafa Scattergood, Ronald O. Koch, Carl C. TI Thermal stability and mechanical properties of nanocrystalline Fe-Ni-Zr alloys prepared by mechanical alloying SO JOURNAL OF MATERIALS SCIENCE LA English DT Article ID GRAIN-BOUNDARY RELAXATION; SOLUTE SEGREGATION; GROWTH; ENERGIES; KINETICS; METALS; BINARY; LINE; SIZE AB The thermal stability of nanostructured Fe100-x-y Ni (x) Zr (y) alloys with Zr additions up to 4 at.% was investigated. This expands upon our previous results for Fe-Ni base alloys that were limited to 1 at.% Zr addition. Emphasis was placed on understanding the effects of composition and microstructural evolution on grain growth and mechanical properties after annealing at temperatures near and above the bcc-to-fcc transformation. Results reveal that microstructural stability can be lost due to the bcc-to-fcc transformation (occurring at 700 A degrees C) by the sudden appearance of abnormally grown fcc grains. However, it was determined that grain growth can be suppressed kinetically at higher temperatures for high Zr content alloys due to the precipitation of intermetallic compounds. Eventually, at higher temperatures and regardless of composition, the retention of nanocrystallinity was lost, leaving behind fine micron grains filled with nanoscale intermetallic precipitates. Despite the increase in grain size, the in situ formed precipitates were found to induce an Orowan hardening effect rivaling that predicted by Hall-Petch hardening for the smallest grain sizes. The transition from grain size strengthening to precipitation strengthening is reported for these alloys. The large grain size and high precipitation hardening result in a material that exhibits high strength and significant plastic straining capacity. C1 [Kotan, Hasan; Saber, Mostafa; Scattergood, Ronald O.; Koch, Carl C.] N Carolina State Univ, Dept Mat Sci & Engn, Raleigh, NC 27695 USA. [Darling, Kris A.] US Army Res Lab, RDRL WMM F, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. RP Kotan, H (reprint author), N Carolina State Univ, Dept Mat Sci & Engn, 911 Partners Way,Room 3078, Raleigh, NC 27695 USA. EM hasankotan@gmail.com OI Saber, Mostafa/0000-0002-6763-8637 FU NSF-DMR [1005677] FX The research reported in this paper was supported by NSF-DMR under Grant Number 1005677. NR 42 TC 11 Z9 11 U1 5 U2 54 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0022-2461 J9 J MATER SCI JI J. Mater. Sci. PD DEC PY 2013 VL 48 IS 24 BP 8402 EP 8411 DI 10.1007/s10853-013-7652-7 PG 10 WC Materials Science, Multidisciplinary SC Materials Science GA 214DS UT WOS:000324111700007 ER PT J AU Veith, GJ AF Veith, George J. TI Kontum: The Battle to Save South Vietnam SO JOURNAL OF COLD WAR STUDIES LA English DT Book Review C1 [Veith, George J.] USA, Washington, DC USA. NR 1 TC 0 Z9 0 U1 0 U2 4 PU MIT PRESS PI CAMBRIDGE PA 55 HAYWARD STREET, CAMBRIDGE, MA 02142 USA SN 1520-3972 J9 J COLD WAR STUD JI J. Cold War Stud. PD WIN PY 2013 VL 15 IS 1 BP 147 EP 149 PG 3 WC History; International Relations; Political Science SC History; International Relations; Government & Law GA 139MN UT WOS:000318586900007 ER PT J AU Chenine, AL Wieczorek, L Sanders-Buell, E Wesberry, M Towle, T Pillis, DM Molnar, S McLinden, R Edmonds, T Hirsch, I O'Connell, R McCutchan, FE Montefiori, DC Ochsenbauer, C Kappes, JC Kim, JH Polonis, VR Tovanabutra, S AF Chenine, Agnes-Laurence Wieczorek, Lindsay Sanders-Buell, Eric Wesberry, Maggie Towle, Teresa Pillis, Devin M. Molnar, Sebastian McLinden, Robert Edmonds, Tara Hirsch, Ivan O'Connell, Robert McCutchan, Francine E. Montefiori, David C. Ochsenbauer, Christina Kappes, John C. Kim, Jerome H. Polonis, Victoria R. Tovanabutra, Sodsai TI Impact of HIV-1 Backbone on Neutralization Sensitivity: Neutralization Profiles of Heterologous Envelope Glycoproteins Expressed in Native Subtype C and CRF01_AE Backbone SO PLOS ONE LA English DT Article ID IMMUNODEFICIENCY-VIRUS TYPE-1; INFECTIOUS MOLECULAR CLONES; ANTIBODY NEUTRALIZATION; CYTOPLASMIC DOMAIN; TERMINAL TAIL; PROTEIN P17; ENV CLONES; GP41; VACCINE; EPITOPE AB Standardized assays to assess vaccine and antiviral drug efficacy are critical for the development of protective HIV-1 vaccines and drugs. These immune assays will be advanced by the development of standardized viral stocks, such as HIV-1 infectious molecular clones (IMC), that i) express a reporter gene, ii) are representative of globally diverse subtypes and iii) are engineered to easily exchange envelope (env) genes for expression of sequences of interest. Thus far, a subtype B IMC backbone expressing Renilla luciferase (LucR), and into which the ectodomain of heterologous env coding sequences can be expressed has been successfully developed but as execution of HIV-1 vaccine efficacy trials shifts increasingly to non-subtype B epidemics (Southern African and Southeast Asia), non-subtype B HIV-1 reagents are needed to support vaccine development. Here we describe two IMCs derived from subtypes C and CRF01_AE HIV-1 primary isolates expressing LucR (IMC. LucR) that were engineered to express heterologous gp160 Envs. 18 constructs expressing various subtypes C and CRF01_AE Envs, mostly acute, in subtype-matched and -unmatched HIV backbones were tested for functionality and neutralization sensitivity. Our results suggest a possible effect of non-env HIV-1 genes on the interaction of Env and neutralizing antibodies and highlight the need to generate a library of IMCs representative of the HIV-1 subtype spectrum to be used as standardized neutralization assay reagents for assessing HIV-1 vaccine efficacy. C1 [Chenine, Agnes-Laurence; Wieczorek, Lindsay; Sanders-Buell, Eric; Wesberry, Maggie; Towle, Teresa; Pillis, Devin M.; Molnar, Sebastian; McLinden, Robert; Tovanabutra, Sodsai] Henry M Jackson Fdn, Bethesda, MD 20817 USA. [Chenine, Agnes-Laurence; Wieczorek, Lindsay; Sanders-Buell, Eric; Wesberry, Maggie; Towle, Teresa; Pillis, Devin M.; Molnar, Sebastian; McLinden, Robert; O'Connell, Robert; Kim, Jerome H.; Polonis, Victoria R.; Tovanabutra, Sodsai] Mil HIV Res Program, Silver Spring, MD USA. [Edmonds, Tara; Ochsenbauer, Christina; Kappes, John C.] Univ Alabama Birmingham, Birmingham, AL USA. [O'Connell, Robert; Kim, Jerome H.; Polonis, Victoria R.] Walter Reed Army Inst Res, Silver Spring, MD USA. [McCutchan, Francine E.] Bill & Melinda Gates Fdn, Seattle, WA USA. [Montefiori, David C.] Duke Univ, Durham, NC USA. [Hirsch, Ivan] Ctr Rech Cancerol Marseille, Inserm UMR891, Marseille, France. RP Chenine, AL (reprint author), Henry M Jackson Fdn, Bethesda, MD 20817 USA. EM alchenine@hivresearch.org RI Hirsch, Ivan/J-7726-2015; OI Hirsch, Ivan/0000-0003-1701-1438 FU U.S. Army Medical Research and Material Command [DAMD17-93-V-3004]; Henry M. Jackson Foundation for the Advancement of Military Medicine, working with the Division of AIDS, National Institute of Allergy and Infectious Diseases National Institutes of Health; Bill & Melinda Gates Foundation Collaboration for AIDS Vaccine Discovery (CAVD) [38619] FX This work was supported by Cooperative Agreement no. DAMD17-93-V-3004 between the U.S. Army Medical Research and Material Command; the Henry M. Jackson Foundation for the Advancement of Military Medicine, working with the Division of AIDS, National Institute of Allergy and Infectious Diseases National Institutes of Health; the Bill & Melinda Gates Foundation Collaboration for AIDS Vaccine Discovery (CAVD), grant number 38619. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 47 TC 5 Z9 5 U1 0 U2 3 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD NOV 29 PY 2013 VL 8 IS 11 AR UNSP e76104 DI 10.1371/journal.pone.0076104 PG 12 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 261MX UT WOS:000327670300002 PM 24312165 ER PT J AU Richter-Menge, JA Farrell, SL AF Richter-Menge, Jacqueline A. Farrell, Sinead L. TI Arctic sea ice conditions in spring 2009-2013 prior to melt SO GEOPHYSICAL RESEARCH LETTERS LA English DT Article DE sea ice thickness; Arctic; observations ID THICKNESS AB Measurements from NASA IceBridge airborne surveys in March/April 2009-2013 over the western Arctic Ocean are presented in the context of previous observations to assess changes in the characteristics of the sea ice cover during the last decade, taking into account spatial and temporal limitations in the available data. Following a precipitous drop in the amount and thickness of multiyear (MY) ice in 2007-2008, the characteristics of the ice cover have remained largely consistent through March 2013. The central Arctic continues to be dominated by MY ice with mean and modal thicknesses of 3.2m and 2.4m, respectively. The southern Beaufort and Chukchi Sea region is a complex mixture of similar to 75% first-year ice and 25% MY ice. IceBridge observations indicate that the mean thickness in the Beaufort and Chukchi Seas may have decreased from similar to 2.5m to as low as 1.6m over the 5 year period. C1 [Richter-Menge, Jacqueline A.] US Army Corps Engineers, Cold Reg Res & Engn Lab, Engineer Res & Dev Ctr, Hanover, NH 03755 USA. [Farrell, Sinead L.] Univ Maryland, Earth Syst Sci Interdisciplinary Ctr, College Pk, MD 20742 USA. RP Richter-Menge, JA (reprint author), US Army Corps Engineers, Cold Reg Res & Engn Lab, Engineer Res & Dev Ctr, 72 Lyme Rd, Hanover, NH 03755 USA. EM Jacqueline.A.Richter-Menge@usace.army.mil RI Farrell, Sinead/F-5586-2010 OI Farrell, Sinead/0000-0003-3222-2751 FU NASA [NNX13AK36G] FX The authors thank the reviewers whose comments were helpful in the revision of this paper. We acknowledge the efforts of the IceBridge team responsible for producing the standard and quick-look IceBridge data products. In particular, we thank the IceBridge Instrument Teams, Science Team, and Project Science Office, as well as the aircraft support crew, for their diligent efforts in gathering and processing these data. This work was supported by NASA grant NNX13AK36G. NR 20 TC 14 Z9 15 U1 0 U2 22 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA SN 0094-8276 EI 1944-8007 J9 GEOPHYS RES LETT JI Geophys. Res. Lett. PD NOV 28 PY 2013 VL 40 IS 22 BP 5888 EP 5893 DI 10.1002/2013GL058011 PG 6 WC Geosciences, Multidisciplinary SC Geology GA 268ZX UT WOS:000328210600012 ER PT J AU Yim, JH Fleischman, MS Rodriguez-Santiago, V Piehler, LT Williams, AA Leadore, JL Pappas, DD AF Yim, Jacqueline H. Fleischman, Michelle S. Rodriguez-Santiago, Victor Piehler, Lars T. Williams, Andre A. Leadore, Julia L. Pappas, Daphne D. TI Development of Antimicrobial Coatings by Atmospheric Pressure Plasma Using a Guanidine-Based Precursor SO ACS APPLIED MATERIALS & INTERFACES LA English DT Article DE guanidine; antimicrobial; atmospheric pressure plasma; plasma enhanced-chemical vapor deposition; ultra high molecular weight polyethylene (UHMWPE); textiles ID CONTAINING MONOMERS; POLYMER; BIOCIDE; FIBERS AB Antimicrobial coatings deposited onto ultra high molecular weight polyethylene (UHMWPE) films were investigated using an atmospheric pressure - plasma enhanced chemical vapor deposition (AP-PECVD) process. Varying concentrations of a guanidine-based liquid precursor, 1,1,3,3-tetramethylguanidine, were used, and different deposition conditions were studied. Attenuated total reflectance - Fourier Transform Infrared (ATR-FTIR) spectroscopy and X-ray Photoelectron Spectroscopy (XPS) were used to study the chemical structure and elemental composition of the coatings. Conformity, morphology, and coating thickness were assessed through SEM and AFM. Optimal AP-PECVD parameters were chosen and applied to deposit guanidine coatings onto woven fabrics. The coatings exhibited high antimicrobial activity against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) based on a modified-AATCC 100 test standard, where 2-5 log reductions were achieved. C1 [Yim, Jacqueline H.; Fleischman, Michelle S.; Rodriguez-Santiago, Victor; Piehler, Lars T.; Williams, Andre A.; Leadore, Julia L.; Pappas, Daphne D.] US Army Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. RP Rodriguez-Santiago, V (reprint author), US Army Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. EM victor.rodriguez31@us.army.mil FU Postgraduate Research Program at the U.S. Army Research Laboratory FX We thank Dr. Joshua Orlicki for his help with the proposed mechanism of TMG deposition. This research was supported in part by an appointment to the Postgraduate Research Program at the U.S. Army Research Laboratory administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the U.S. Department of Energy and USARL. NR 29 TC 2 Z9 2 U1 4 U2 37 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1944-8244 J9 ACS APPL MATER INTER JI ACS Appl. Mater. Interfaces PD NOV 27 PY 2013 VL 5 IS 22 BP 11836 EP 11843 DI 10.1021/am403503a PG 8 WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary SC Science & Technology - Other Topics; Materials Science GA 263MI UT WOS:000327812300048 PM 24164174 ER PT J AU Soller, B Smith, C Zou, FM Sondeen, J AF Soller, Babs Smith, Charles Zou, Fengmei Sondeen, Jill TI Comparison of Noninvasive pHm and Blood pH in a Swine Model of Resuscitation or Uncontrolled Hemorrhage SO CIRCULATION LA English DT Meeting Abstract CT Scientific Sessions and Resuscitation Science Symposium of the American-Heart-Association CY NOV 16-17, 2013 CL Dallas, TX SP Amer Heart Assoc C1 [Soller, Babs] Reflectance Med Inc, Rsch & Dev, Westborough, MA USA. [Smith, Charles; Zou, Fengmei] Reflectance Med Inc, Westborough, MA USA. [Sondeen, Jill] US Army Inst Surg Rsch, San Antonio, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0009-7322 EI 1524-4539 J9 CIRCULATION JI Circulation PD NOV 26 PY 2013 VL 128 IS 22 SU S MA 207 PG 1 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA AC0CR UT WOS:000332162900149 ER PT J AU Beck, Z Jagodzinski, LL Eller, MA Thelian, D Matyas, GR Kunz, AN Alving, CR AF Beck, Zoltan Jagodzinski, Linda L. Eller, Michael A. Thelian, Doris Matyas, Gary R. Kunz, Anjali N. Alving, Carl R. TI Platelets and Erythrocyte-Bound Platelets Bind Infectious HIV-1 in Plasma of Chronically Infected Patients SO PLOS ONE LA English DT Article ID DUFFY ANTIGEN RECEPTOR; IMMUNODEFICIENCY-VIRUS TYPE-1; TO-CELL SPREAD; DC-SIGN; ANTIRETROVIRAL THERAPY; VIROLOGICAL SYNAPSES; DISEASE PROGRESSION; AFRICAN-AMERICANS; CHEMOKINES DARC; TRANS-INFECTION AB Chronic HIV-1 infection is associated with persistent viremia in most patients, but it remains unclear how free virus may survive the potential hostile effects of plasma. We investigated whether sites might exist on the surfaces of circulating blood cells for protection of infectious HIV-1 particles. Red blood cells (RBC) either from blood of uninfected normal individuals, or from blood obtained without EDTA from chronically infected HIV-1 patients, invariably contained a small number of RBC having attached platelets as determined by flow cytometry, light microscopy, and immunofluorescence microscopy. After mixing normal RBC with platelet-rich plasma, discrete populations of RBC, platelets, and complexes of platelets attached to RBC were purified by fluorescence-activated cell sorting. Upon incubation of purified cells or platelets with HIV-1 followed by washing and co-incubation with CD4-positive peripheral blood mononuclear cells (PBMC), platelets, and platelet-RBC complexes, but not platelet-free RBC, caused infection of PBMC. Infection was prevented by pre-treating the platelet-RBC complexes with EDTA. Plasma and RBC (comprising a RBC/platelet-RBC mixture) from chronically infected patients with low viral loads were also co-incubated with PBMC ex vivo to determine the presence of infectious HIV-1. All freshly isolated plasmas from the HIV-1-infected donors, obtained in the absence of anticoagulant, were noninfectious. Interestingly, the RBC from most of the patients caused cell-cell infection of PBMC that was prevented by stripping the RBC with EDTA. A monoclonal antibody to DC-SIGN partially inhibited cell-cell HIV-1 infection of PBMC by normal RBC pre-incubated with platelets and HIV-1. We conclude: (a) platelet-free EDTA-free plasma from chronically infected HIV-1 patients, although containing viral RNA, is an environment that lacks detectable infectious HIV-1; (b) platelets and platelet-RBC complexes, but not purified RBC, bind infectious HIV-1; (c) DC-SIGN, and possibly other C-type lectins, may represent binding sites for infectious HIV-1 on platelets and platelet-RBC complexes. C1 [Beck, Zoltan; Jagodzinski, Linda L.; Eller, Michael A.; Thelian, Doris; Matyas, Gary R.; Kunz, Anjali N.; Alving, Carl R.] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD USA. [Beck, Zoltan; Eller, Michael A.; Thelian, Doris] Henry M Jackson Fdn Adv Mil Med, Silver Spring, MD USA. RP Alving, CR (reprint author), Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD USA. EM calving@hivresearch.org OI Matyas, Gary/0000-0002-2074-2373 FU Henry M. Jackson Foundation for the Advancement of Military Medicine Inc. [W81XWH-07-2-0067]; U.S. Medical Research and Material Command [W81XWH-07-2-0067] FX This work was supported by cooperative agreement W81XWH-07-2-0067, between the Henry M. Jackson Foundation for the Advancement of Military Medicine Inc. and the U.S. Medical Research and Material Command. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 51 TC 2 Z9 2 U1 1 U2 3 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD NOV 25 PY 2013 VL 8 IS 11 AR e81002 DI 10.1371/journal.pone.0081002 PG 10 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 259RH UT WOS:000327543500064 PM 24282562 ER PT J AU Sliozberg, YR Chantawansri, TL AF Sliozberg, Yelena R. Chantawansri, Tanya L. TI Computational study of imperfect networks using a coarse-grained model SO JOURNAL OF CHEMICAL PHYSICS LA English DT Article ID LINKED POLYMER NETWORKS; NONEQUILIBRIUM MOLECULAR-DYNAMICS; STRUCTURAL-PROPERTIES; MONTE-CARLO; MELTS; SIMULATIONS; STRESS; GELS; EQUILIBRATION AB The structural and mechanical properties of imperfect entangled polymer networks with various fractions of elastically active chains are studied using a generic coarse-grained model. Network topology is analyzed at various degrees of cross-linking and correlated with the mechanical response under uniaxial deformation at various strain rates. We found excellent agreement between results obtained from the structural analysis and from fitting to stress relaxation data. The relaxation tensile modulus at various engineering strains was also calculated as a function of the fraction of active strands. Results indicate that the mechanical and viscoelastic properties of entangled polymer networks are susceptible to variation in the network structure, where defects can affect the mechanical response especially at low strain rates and the relaxation behavior at long times. (C) 2013 AIP Publishing LLC. C1 [Sliozberg, Yelena R.] Bowhead Sci & Technol, King George, VA 22485 USA. [Sliozberg, Yelena R.; Chantawansri, Tanya L.] US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Sliozberg, YR (reprint author), Bowhead Sci & Technol, 15163 Dahlgren Rd, King George, VA 22485 USA. EM yelena.r.sliozberg.ctr@mail.mil NR 32 TC 3 Z9 3 U1 1 U2 19 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0021-9606 EI 1089-7690 J9 J CHEM PHYS JI J. Chem. Phys. PD NOV 21 PY 2013 VL 139 IS 19 AR 194904 DI 10.1063/1.4832140 PG 8 WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical SC Chemistry; Physics GA 262DS UT WOS:000327714900046 PM 24320352 ER PT J AU Subramanyam, G Cole, MW Sun, NX Kalkur, TS Sbrockey, NM Tompa, GS Guo, XM Chen, CL Alpay, SP Rossetti, GA Dayal, K Chen, LQ Schlom, DG AF Subramanyam, Guru Cole, M. W. Sun, Nian X. Kalkur, Thottam S. Sbrockey, Nick M. Tompa, Gary S. Guo, Xiaomei Chen, Chonglin Alpay, S. P. Rossetti, G. A., Jr. Dayal, Kaushik Chen, Long-Qing Schlom, Darrell G. TI Challenges and opportunities for multi-functional oxide thin films for voltage tunable radio frequency/microwave components SO JOURNAL OF APPLIED PHYSICS LA English DT Review ID MOLECULAR-BEAM EPITAXY; FERROELECTRIC SOLID-SOLUTIONS; STRONTIUM-TITANATE FILMS; PULSED-LASER DEPOSITION; MICROWAVE DIELECTRIC-PROPERTIES; CHEMICAL-VAPOR-DEPOSITION; NICO-FERRITE FILMS; ROOM-TEMPERATURE; PARAELECTRIC BILAYERS; MINIATURIZED ANTENNAS AB There has been significant progress on the fundamental science and technological applications of complex oxides and multiferroics. Among complex oxide thin films, barium strontium titanate (BST) has become the material of choice for room-temperature-based voltage-tunable dielectric thin films, due to its large dielectric tunability and low microwave loss at room temperature. BST thin film varactor technology based reconfigurable radio frequency (RF)/microwave components have been demonstrated with the potential to lower the size, weight, and power needs of a future generation of communication and radar systems. Low-power multiferroic devices have also been recently demonstrated. Strong magneto-electric coupling has also been demonstrated in different multiferroic heterostructures, which show giant voltage control of the ferromagnetic resonance frequency of more than two octaves. This manuscript reviews recent advances in the processing, and application development for the complex oxides and multiferroics, with the focus on voltage tunable RF/microwave components. The over-arching goal of this review is to provide a synopsis of the current state-of the-art of complex oxide and multiferroic thin film materials and devices, identify technical issues and technical challenges that need to be overcome for successful insertion of the technology for both military and commercial applications, and provide mitigation strategies to address these technical challenges. (C) 2013 AIP Publishing LLC. C1 [Subramanyam, Guru] Univ Dayton, Dept Elect & Comp Engn, Dayton, OH 45469 USA. [Cole, M. W.] US Army, Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. [Sun, Nian X.] Northeastern Univ, Dept Elect & Comp Engn, Boston, MA 02115 USA. [Kalkur, Thottam S.] Univ Colorado, Dept Elect & Comp Engn, Colorado Springs, CO 80918 USA. [Sbrockey, Nick M.; Tompa, Gary S.] Struct Mat Ind Inc, Piscataway, NJ 08854 USA. [Guo, Xiaomei] Boston Appl Technol Inc, Woburn, MA 01801 USA. [Chen, Chonglin] Univ Texas San Antonio, Dept Phys & Astron, San Antonio, TX 78249 USA. [Alpay, S. P.; Rossetti, G. A., Jr.] Univ Connecticut, Inst Mat Sci, Storrs, CT 06269 USA. [Alpay, S. P.; Rossetti, G. A., Jr.] Univ Connecticut, Mat Sci & Engn Program, Storrs, CT 06269 USA. [Dayal, Kaushik] Carnegie Mellon Univ, Pittsburgh, PA 15213 USA. [Chen, Long-Qing] Penn State Univ, Dept Mat Sci & Engn, University Pk, PA 16802 USA. [Schlom, Darrell G.] Cornell Univ, Dept Mat Sci & Engn, Ithaca, NY 14853 USA. [Schlom, Darrell G.] Kavli Inst Cornell Nanoscale Sci, Ithaca, NY 14853 USA. RP Subramanyam, G (reprint author), Univ Dayton, Dept Elect & Comp Engn, Dayton, OH 45469 USA. EM gsubramanyam1@udayton.edu; melanie.w.cole.civ@mail.mil RI Alpay, Pamir/E-2666-2013; Rossetti, George/E-4401-2014; Chen, LongQing/I-7536-2012; Sun, Nian Xiang/F-9590-2010; OI Chen, LongQing/0000-0003-3359-3781; Sun, Nian Xiang/0000-0002-3120-0094; Dayal, Kaushik/0000-0002-0516-3066 FU Army Research Laboratory (ARL); Army Research Office (ARO) FX This manuscript is an outcome from the 2012 Workshop on Multifunctional Oxides sponsored by Army Research Laboratory (ARL) and the Army Research Office (ARO). The authors acknowledge the contributions of attendees of the workshop, including Professor Greg Carman (UCLA), Professor Stefan Zollner (New Mexico State), Professor Juan Nino (Florida), Professor Jacob Jones (Florida), Professor Mingzhong Wu (Colorado State), Dr. Kos Galatsis (Aneeve Tech), Dr. Pooran Joshi (Oak Ridge National Lab), Dr. Chakrapani Varanasi (ARO), and Dr. Mark Ulrich (ARO). Special thanks to Dustin Brown, University of Dayton, Ph.D. student for some of the redrawn art work. NR 212 TC 54 Z9 54 U1 22 U2 173 PU AMER INST PHYSICS PI MELVILLE PA 1305 WALT WHITMAN RD, STE 300, MELVILLE, NY 11747-4501 USA SN 0021-8979 EI 1089-7550 J9 J APPL PHYS JI J. Appl. Phys. PD NOV 21 PY 2013 VL 114 IS 19 AR 191301 DI 10.1063/1.4827019 PG 35 WC Physics, Applied SC Physics GA 260JZ UT WOS:000327592400001 ER PT J AU Wilber, DH Davis, D Clarke, DG Alcoba, CJ Gallo, J AF Wilber, Dara H. Davis, David Clarke, Douglas G. Alcoba, Catherine J. Gallo, Jenine TI Winter flounder (Pseudopleuronectes americanus) estuarine habitat use and the association between spring temperature and subsequent year class strength SO ESTUARINE COASTAL AND SHELF SCIENCE LA English DT Article DE life history correlations; spawning season; navigation channel ID SHRIMP CRANGON-SEPTEMSPINOSA; OF-THE-YEAR; PLEURONECTES-AMERICANUS; SECONDARY PRODUCTION; NEW-YORK; MOVEMENT PATTERNS; NARRAGANSETT BAY; RHODE-ISLAND; NEW-JERSEY; LARVAL AB Winter flounder habitat use in New York/New Jersey Harbor was examined through a long-term (2002 2010) bottom trawl sampling program (Aquatic Biological Survey) in which 5234 winter flounder were captured in 2069 samples collected at approximately 26 stations throughout the harbor. Interannual variability in catch-per-unit-effort (CPUE) primarily was attributable to fluctuations in Year-1 juvenile CPUE, which was positively correlated with total annual egg abundances from the previous year. Adult male CPUE during the spawning season was positively correlated with total egg abundances of the same year, whereas adult female CPUE was unrelated to annual egg abundances in the harbor. Annual variation in adult male densities in the harbor during the spawning season reflects the intensity of estuarine spawning activity, whereas adult female densities may include non-reproductive, foraging individuals. Seasonal fluctuations in condition indices reflected energy use during the spawning season, with relatively high condition in January, reduced levels in March and April, and elevated condition again in May. Adult CPUE peaked in April, coincident with the critical feeding period that follows spawning. Mean April water temperatures were positively correlated with egg abundances the following year and Year-1 juvenile CPUE two years later. A similar correlation between April temperatures and Year-1 juvenile abundances two years later was demonstrated using published data for winter flounder collected in Niantic Bay, CT. Higher April water temperatures may enhance benthic secondary production during the critical feeding period, and thus increase prey availability for foraging adults that need to restore energy reserves in order to reproduce the following year. A direct examination of benthic secondary production and variation in winter flounder estuarine foraging and subsequent spawning activity is needed to more fully understand this relationship. (C) 2013 Elsevier Ltd. All rights reserved. C1 [Wilber, Dara H.] Bowhead Sci & Technol, Charleston, SC 29412 USA. [Davis, David; Clarke, Douglas G.] HDR Engn Inc, Pearl River, NY 10965 USA. [Alcoba, Catherine J.; Gallo, Jenine] US Army Corps Engineers, New York, NY 10278 USA. RP Wilber, DH (reprint author), Bowhead Sci & Technol, 664 Old Plantat Rd, Charleston, SC 29412 USA. EM darawilber@gmail.com FU U. S. Army Corps of Engineers New York District FX We appreciate the thoughtful comments provided in discussions with Ken Able, Chris Chambers, Don Danila, and Elizabeth Fairchild and the careful reviews of two anonymous reviewers. Funding for this project was provided by the U. S. Army Corps of Engineers New York District and the Port Authority of New York and New Jersey in support of the 50-foot Harbor Deepening Project (HDP). NR 54 TC 2 Z9 2 U1 0 U2 17 PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD PI LONDON PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND SN 0272-7714 EI 1096-0015 J9 ESTUAR COAST SHELF S JI Estuar. Coast. Shelf Sci. PD NOV 20 PY 2013 VL 133 BP 251 EP 259 DI 10.1016/j.ecss.2013.09.004 PG 9 WC Marine & Freshwater Biology; Oceanography SC Marine & Freshwater Biology; Oceanography GA 250JD UT WOS:000326848200026 ER PT J AU Vaidya, SA Streeck, H Beckwith, N Ghebremichael, M Pereyra, F Kwon, DS Addo, MM Rychert, J Routy, JP Jessen, H Kelleher, AD Hecht, F Sekaly, RP Carrington, M Walker, BD Allen, TM Rosenberg, ES Altfeld, M AF Vaidya, Sagar A. Streeck, Hendrik Beckwith, Noor Ghebremichael, Musie Pereyra, Florencia Kwon, Douglas S. Addo, Marylyn M. Rychert, Jenna Routy, Jean-Pierre Jessen, Heiko Kelleher, Anthony D. Hecht, Frederick Sekaly, Rafick-Pierre Carrington, Mary Walker, Bruce D. Allen, Todd M. Rosenberg, Eric S. Altfeld, Marcus TI Temporal effect of HLA-B*57 on viral control during primary HIV-1 infection SO RETROVIROLOGY LA English DT Article DE HLA-B*57; HLA-B; Acute HIV-1 infection; Primary HIV-1 infection; Viral load set point; MHC class I ID HLA; DETERMINANTS AB Background: HLA-B alleles are associated with viral control in chronic HIV-1 infection, however, their role in primary HIV-1 disease is unclear. This study sought to determine the role of HLA-B alleles in viral control during the acute phase of HIV-1 infection and establishment of the early viral load set point (VLSP). Findings: Individuals identified during primary HIV-1 infection were HLA class I typed and followed longitudinally. Associations between HLA-B alleles and HIV-1 viral replication during acute infection and VLSP were analyzed in untreated subjects. The results showed that neither HLA-B*57 nor HLA-B*27 were significantly associated with viral control during acute HIV-1 infection (Fiebig stage I-IV, n= 171). HLA-B*57 was however significantly associated with a subsequent lower VLSP (p< 0.001, n= 135) with nearly 1 log(10) less median viral load. Analysis of a known polymorphism at position 97 of HLA-B showed significant associations with both lower initial viral load (p< 0.01) and lower VLSP (p< 0.05). However, this association was dependent on different amino acids at this position for each endpoint. Conclusions: The effect of HLA-B*57 on viral control is more pronounced during the later stages of primary HIV-1 infection, which suggests the underlying mechanism of control occurs at a critical period in the first several months after HIV-1 acquisition. The risk profile of polymorphisms at position 97 of HLA-B are more broadly associated with HIV-1 viral load during primary infection and may serve as a focal point in further studies of HLA-B function. C1 [Vaidya, Sagar A.; Streeck, Hendrik; Beckwith, Noor; Ghebremichael, Musie; Pereyra, Florencia; Kwon, Douglas S.; Addo, Marylyn M.; Rychert, Jenna; Walker, Bruce D.; Allen, Todd M.; Altfeld, Marcus] MIT, Ragon Inst MGH, Boston, MA USA. [Vaidya, Sagar A.; Streeck, Hendrik; Beckwith, Noor; Ghebremichael, Musie; Pereyra, Florencia; Kwon, Douglas S.; Addo, Marylyn M.; Rychert, Jenna; Walker, Bruce D.; Allen, Todd M.; Altfeld, Marcus] Harvard Univ, Massachusetts Gen Hosp, Boston, MA 02115 USA. [Vaidya, Sagar A.; Rosenberg, Eric S.] Massachusetts Gen Hosp, Div Infect Dis, Boston, MA 02114 USA. [Streeck, Hendrik] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD USA. [Streeck, Hendrik] Henry M Jackson Fdn Advancement Mil Med, Bethesda, MD USA. [Addo, Marylyn M.] Univ Med Ctr Hamburg Eppendorf, Infect Dis Unit, Hamburg, Germany. [Routy, Jean-Pierre] McGill Univ, Div Hematol, Montreal, PQ, Canada. [Routy, Jean-Pierre] McGill Univ, Chron Viral Illness Serv MUHC, Montreal, PQ, Canada. [Jessen, Heiko] HIV Clin Praxis Jessen, Berlin, Germany. [Kelleher, Anthony D.] Univ New S Wales, Natl Ctr HIV Epidemiol & Clin Res, Darlinghurst, NSW, Australia. [Hecht, Frederick] Univ Calif San Francisco, San Francisco Gen Hosp, Dept Med, San Francisco, CA USA. [Sekaly, Rafick-Pierre] Univ Miami, Miller Sch Med, Dept Microbiol & Immunol, Miami, FL 33136 USA. [Carrington, Mary] Leidos Biomed Res Inc, Expt Immunol Lab, Canc & Inflammat Program, Frederick Natl Labs Canc Res, Frederick, MD USA. [Walker, Bruce D.] Howard Hughes Med Inst, Chevy Chase, MD USA. [Altfeld, Marcus] Heinrich Pette Inst, Hamburg, Germany. RP Altfeld, M (reprint author), MIT, Ragon Inst MGH, Boston, MA USA. EM maltfeld@partners.org RI Allen, Todd/F-5473-2011; OI Beckwith, Noor/0000-0001-6025-8642 FU Frederick National Laboratory for Cancer Research [HHSN261200800001E]; Intramural Research Program of the NIH, Frederick National Lab, Center for Cancer Research FX This project has been funded in whole or in part with federal funds from the Frederick National Laboratory for Cancer Research, under Contract No. HHSN261200800001E. The content of this publication does not necessarily reflect the views or policies of the Department of Health and Human Services, nor does mention of trade names, commercial products, or organizations imply endorsement by the U.S. Government. This Research was supported in part by the Intramural Research Program of the NIH, Frederick National Lab, Center for Cancer Research. NR 14 TC 6 Z9 7 U1 1 U2 5 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1742-4690 J9 RETROVIROLOGY JI Retrovirology PD NOV 18 PY 2013 VL 10 AR 139 DI 10.1186/1742-4690-10-139 PG 5 WC Virology SC Virology GA 280QV UT WOS:000329046800002 PM 24245727 ER PT J AU Laurens, MB Thera, MA Coulibaly, D Ouattara, A Kone, AK Guindo, AB Traore, K Traore, I Kouriba, B Diallo, DA Diarra, I Daou, M Dolo, A Tolo, Y Sissoko, MS Niangaly, A Sissoko, M Takala-Harrison, S Lyke, KE Wu, YK Blackwelder, WC Godeaux, O Vekemans, J Dubois, MC Ballou, WR Cohen, J Dube, T Soisson, L Diggs, CL House, B Bennett, JW Lanar, DE Dutta, S Heppner, DG Plowe, CV Doumbo, OK AF Laurens, Matthew B. Thera, Mahamadou A. Coulibaly, Drissa Ouattara, Amed Kone, Abdoulaye K. Guindo, Ando B. Traore, Karim Traore, Idrissa Kouriba, Bourema Diallo, Dapa A. Diarra, Issa Daou, Modibo Dolo, Amagana Tolo, Youssouf Sissoko, Mahamadou S. Niangaly, Amadou Sissoko, Mady Takala-Harrison, Shannon Lyke, Kirsten E. Wu, Yukun Blackwelder, William C. Godeaux, Olivier Vekemans, Johan Dubois, Marie-Claude Ballou, W. Ripley Cohen, Joe Dube, Tina Soisson, Lorraine Diggs, Carter L. House, Brent Bennett, Jason W. Lanar, David E. Dutta, Sheetij Heppner, D. Gray Plowe, Christopher V. Doumbo, Ogobara K. TI Extended Safety, Immunogenicity and Efficacy of a Blood-Stage Malaria Vaccine in Malian Children: 24-Month Follow-Up of a Randomized, Double-Blinded Phase 2 Trial SO PLOS ONE LA English DT Article ID APICAL MEMBRANE ANTIGEN-1; ALLELE-SPECIFIC EFFICACY; INSTITUTE-OF-RESEARCH; PLASMODIUM-FALCIPARUM; CANDIDATE; AMA1; POLYMORPHISM; BANDIAGARA; INFANTS; ADULTS AB Background: The FMP2.1/AS02(A) candidate malaria vaccine was tested in a Phase 2 study in Mali. Based on results from the first eight months of follow-up, the vaccine appeared well-tolerated and immunogenic. It had no significant efficacy based on the primary endpoint, clinical malaria, but marginal efficacy against clinical malaria in secondary analyses, and high allele-specific efficacy. Extended follow-up was conducted to evaluate extended safety, immunogenicity and efficacy. Methods: A randomized, double-blinded trial of safety, immunogenicity and efficacy of the candidate Plasmodium falciparum apical membrane antigen 1 (AMA1) vaccine FMP2.1/AS02(A) was conducted in Bandiagara, Mali. Children aged 1-6 years were randomized in a 1: 1 ratio to receive FMP2.1/AS02(A) or control rabies vaccine on days 0, 30 and 60. Using active and passive surveillance, clinical malaria and adverse events as well as antibodies against P. falciparum AMA1 were monitored for 24 months after the first vaccination, spanning two malaria seasons. Findings: 400 children were enrolled. Serious adverse events occurred in nine participants in the FMP2.1/AS02(A) group and three in the control group; none was considered related to study vaccination. After two years, anti-AMA1 immune responses remained significantly higher in the FMP2.1/AS02(A) group than in the control group. For the entire 24-month follow-up period, vaccine efficacy was 7.6% (p = 0.51) against first clinical malaria episodes and 9.9% (p = 0.19) against all malaria episodes. For the final 16-month follow-up period, vaccine efficacy was 0.9% (p = 0.98) against all malaria episodes. Allele-specific efficacy seen in the first malaria season did not extend into the second season of follow-up. Interpretation: Allele-specific vaccine efficacy was not sustained in the second malaria season, despite continued high levels of anti-AMA1 antibodies. This study presents an opportunity to evaluate correlates of partial protection against clinical malaria that waned during the second malaria season. C1 [Laurens, Matthew B.; Ouattara, Amed; Takala-Harrison, Shannon; Lyke, Kirsten E.; Wu, Yukun; Blackwelder, William C.; Plowe, Christopher V.] Univ Maryland Sch Med, Ctr Vaccine Dev, Howard Hughes Med Inst, Malaria Grp, Baltimore, MD 21228 USA. [Thera, Mahamadou A.; Coulibaly, Drissa; Ouattara, Amed; Kone, Abdoulaye K.; Guindo, Ando B.; Traore, Karim; Traore, Idrissa; Kouriba, Bourema; Diallo, Dapa A.; Diarra, Issa; Daou, Modibo; Dolo, Amagana; Tolo, Youssouf; Sissoko, Mahamadou S.; Niangaly, Amadou; Sissoko, Mady; Doumbo, Ogobara K.] Univ Sci Tech & Technol, Malaria Res & Training Ctr, Bamako, Mali. [Godeaux, Olivier; Vekemans, Johan; Dubois, Marie-Claude; Ballou, W. Ripley; Cohen, Joe] GlaxoSmithKline Vaccines, Rixensart, Belgium. [Dube, Tina] EMMES Corp, Rockville, MD USA. [Soisson, Lorraine; Diggs, Carter L.] US Agcy Int Dev, Malaria Vaccine Dev Program, Washington, DC 20523 USA. [House, Brent; Bennett, Jason W.; Lanar, David E.; Dutta, Sheetij; Heppner, D. Gray] Walter Reed Army Inst Res, US Mil Malaria Vaccine Program, Silver Spring, MD USA. RP Plowe, CV (reprint author), Univ Maryland Sch Med, Ctr Vaccine Dev, Howard Hughes Med Inst, Malaria Grp, Baltimore, MD 21228 USA. EM cplowe@medicine.umaryland.edu RI Laurens, Matthew/E-7293-2013 OI Laurens, Matthew/0000-0003-3874-581X NR 33 TC 12 Z9 12 U1 0 U2 7 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD NOV 18 PY 2013 VL 8 IS 11 AR e79323 DI 10.1371/journal.pone.0079323 PG 9 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 256KH UT WOS:000327308500043 PM 24260195 ER PT J AU Barber, PS Griggs, CS Gurau, G Liu, Z Li, S Li, ZX Lu, XM Zhang, SJ Rogers, RD AF Barber, Patrick S. Griggs, Chris S. Gurau, Gabriela Liu, Zhen Li, Shan Li, Zengxi Lu, Xingmei Zhang, Suojiang Rogers, Robin D. TI Coagulation of Chitin and Cellulose from 1-Ethyl-3-methylimidazolium Acetate Ionic-Liquid Solutions Using Carbon Dioxide SO ANGEWANDTE CHEMIE-INTERNATIONAL EDITION LA English DT Article DE biomass; carbon dioxide; chitin; coagulation; ionic liquids ID DISSOLUTION; BIOREFINERY; SHELLS; WOOD C1 [Barber, Patrick S.; Griggs, Chris S.; Gurau, Gabriela; Rogers, Robin D.] Univ Alabama, Ctr Green Mfg, Tuscaloosa, AL 35487 USA. [Barber, Patrick S.; Griggs, Chris S.; Gurau, Gabriela; Rogers, Robin D.] Univ Alabama, Dept Chem, Tuscaloosa, AL 35487 USA. [Griggs, Chris S.] US Army ERDC Environm Lab, Vicksburg, MS 39180 USA. [Liu, Zhen; Li, Shan; Li, Zengxi] Chinese Acad Sci, Grad Univ, Coll Chem & Chem Engn, Beijing 100049, Peoples R China. [Lu, Xingmei; Zhang, Suojiang; Rogers, Robin D.] Chinese Acad Sci, Grad Univ, Inst Proc Engn, State Key Lab Multiphase Complex Syst, Beijing 100190, Peoples R China. RP Zhang, SJ (reprint author), Chinese Acad Sci, Grad Univ, Inst Proc Engn, State Key Lab Multiphase Complex Syst, Beijing 100190, Peoples R China. EM sjzhang@home.ipe.ac.cn; rdrogers@as.ua.edu RI Lu, Xingmei/P-8132-2014; zhang, suojiang/D-2053-2015; OI Rogers, Robin D./0000-0001-9843-7494 FU Chinese Academy of Sciences [2011T2G24]; U.S. DOE Office of Nuclear Energy's Nuclear Energy University Programs [120427, 3123]; National Natural Science Foundation of China [21210006]; Beijing Municipal Natural Science Foundation [2131005] FX This collaborative effort was supported by the Chinese Academy of Sciences Visiting Professorship for Senior International Scientists (R.D.R., grant number 2011T2G24). The authors gratefully acknowledge the financial support from the U.S. DOE Office of Nuclear Energy's Nuclear Energy University Programs (sub-contract number 120427, project number 3123), the National Natural Science Foundation of China (grant number 21210006), and the Beijing Municipal Natural Science Foundation (grant number 2131005). NR 22 TC 16 Z9 17 U1 11 U2 139 PU WILEY-V C H VERLAG GMBH PI WEINHEIM PA BOSCHSTRASSE 12, D-69469 WEINHEIM, GERMANY SN 1433-7851 EI 1521-3773 J9 ANGEW CHEM INT EDIT JI Angew. Chem.-Int. Edit. PD NOV 18 PY 2013 VL 52 IS 47 BP 12350 EP 12353 DI 10.1002/anie.201304604 PG 4 WC Chemistry, Multidisciplinary SC Chemistry GA 249VN UT WOS:000326807900029 PM 24115399 ER PT J AU Walsh, MR Walsh, ME Ramsey, CA Brochu, S Thiboutot, S Ampleman, G AF Walsh, Michael R. Walsh, Marianne E. Ramsey, Charles A. Brochu, Sylvie Thiboutot, Sonia Ampleman, Guy TI Perchlorate contamination from the detonation of insensitive high-explosive rounds SO JOURNAL OF HAZARDOUS MATERIALS LA English DT Article DE Insensitive high explosives; PAX-21; Detonation residues; Perchlorate; Environmental contamination; Range sustainability ID DEPOSITION RATES; RANGES AB The insensitive high-explosive PAX-21 was the first of its kind fielded in an artillery munition by the United States military. This formulation contains three main components: RDX, dinitroanisole, and ammonium perchlorate (AP). In March 2012, detonation tests were conducted on PAX-21 60 mm mortar rounds to determine the energetic residues resulting from high-order and blow-in-place (BIP) detonations. Post-detonation residues were sampled and analyzed for the three main PAX-21 components. Concentrations of RDX and dinitroanisole in the samples were quite low, less than 0.1% of the munitions' original organic explosive filler mass, indicating high order or near high order detonations. However, disproportionately high concentrations of AP occurred in all residues. The residues averaged 15% of the original AP following high-order detonations and 38% of the original AP mass following the BIP operations. There was no correlation between AP residues and the RDX and dinitroanisole. Perchlorate readily leached from the detonation residues, with over 99% contained in the aqueous portion of the samples. Use of these rounds will result in billions of liters of water contaminated above drinking water perchlorate limits. As a result of this research, PAX-21 mortar rounds are currently restricted from use on US training ranges. Published by Elsevier B.V. C1 [Walsh, Michael R.; Walsh, Marianne E.] USA CRREL, Hanover, NH 03755 USA. [Ramsey, Charles A.] Envirostat Inc, Ft Collins, CO USA. [Brochu, Sylvie; Thiboutot, Sonia; Ampleman, Guy] DRDC Valcartier, Quebec City, PQ G3J 1X5, Canada. RP Walsh, MR (reprint author), USA CRREL, 72 Lyme Rd, Hanover, NH 03755 USA. EM Michael.Walsh@usace.army.mil NR 21 TC 4 Z9 4 U1 0 U2 17 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0304-3894 EI 1873-3336 J9 J HAZARD MATER JI J. Hazard. Mater. PD NOV 15 PY 2013 VL 262 BP 228 EP 233 DI 10.1016/j.jhazmat.2013.08.045 PG 6 WC Engineering, Environmental; Engineering, Civil; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA 288ET UT WOS:000329595500027 PM 24035798 ER PT J AU Krakauer, T Stiles, BG AF Krakauer, Teresa Stiles, Bradley G. TI The staphylococcal enterotoxin (SE) family SEB and siblings SO VIRULENCE LA English DT Review DE SEB; S. aureus; vaccine; therapeutic; superantigen; animal model; cytokine ID TOXIC-SHOCK-SYNDROME; T-CELL-ACTIVATION; MHC CLASS-II; INFLAMMATORY LUNG INJURY; BLOOD MONONUCLEAR-CELLS; TUMOR-NECROSIS-FACTOR; NF-KAPPA-B; IN-VIVO; BACTERIAL SUPERANTIGEN; AUREUS ENTEROTOXIN AB Staphylococcus aureus plays an important role in numerous human cases of food poisoning, soft tissue and bone infections, as well as potentially lethal toxic shock. This common bacterium synthesizes various virulence factors that include staphylococcal enterotoxins (SEs). These protein toxins bind directly to major histocompatibility complex class II on antigen-presenting cells and specific V regions of T-cell receptors, resulting in potentially life-threatening stimulation of the immune system. Picomolar concentrations of SEs ultimately elicit proinflammatory cytokines that can induce fever, hypotension, multi-organ failure, and lethal shock. Various in vitro and in vivo models have provided important tools for studying the biological effects of, as well as potential vaccines/therapeutics against, the SEs. This review succinctly presents known physical and biological properties of the SEs, including various intervention strategies. In particular, SEB will often be portrayed as per biodefense concerns dating back to the 1960s. C1 [Krakauer, Teresa] US Army Med Res Inst Infect Dis, Integrated Toxicol Div, Ft Detrick, MD USA. [Stiles, Bradley G.] Wilson Coll, Chambersburg, PA USA. RP Krakauer, T (reprint author), US Army Med Res Inst Infect Dis, Integrated Toxicol Div, Ft Detrick, MD USA. EM teresa.krakauer@us.army.mil FU Defense Threat Reduction Agency FX We thank the Defense Threat Reduction Agency for generous support. The views expressed in this publication are those of the author and do not reflect the official policy or position of the Department of the Army, the Department of Defense, or the US government. NR 155 TC 13 Z9 17 U1 5 U2 19 PU LANDES BIOSCIENCE PI AUSTIN PA 1806 RIO GRANDE ST, AUSTIN, TX 78702 USA SN 2150-5594 EI 2150-5608 J9 VIRULENCE JI Virulence PD NOV 15 PY 2013 VL 4 IS 8 BP 759 EP 773 DI 10.4161/viru.23905 PG 15 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 257XK UT WOS:000327420900015 PM 23959032 ER PT J AU Chang, YC Wang, C Yin, SZ Hoffman, RC Mott, AG AF Chang, Yun-Ching Wang, Chao Yin, Shizhuo Hoffman, Robert C. Mott, Andrew G. TI Giant electro-optic effect in nanodisordered KTN crystals SO OPTICS LETTERS LA English DT Article ID RELAXOR FERROELECTRICS; MODULATORS; SYSTEMS; FIELD AB The electro-optic (EO) effect in nanodisordered potassium tantalate niobate (KTN) crystal is quantitatively investigated. It is found out that the EO coefficient of nanodisordered KTN crystal depends not only on the cooling temperature but also on the cooling rate. A larger EO coefficient can be obtained by employing a faster cooling rate. A Kerr EO efficient (s(11)-s(12) = 6.94 x 10(-14) m(2)/V-2) is obtained at a cooling rate of 0.45 degrees C/s. The enhanced EO efficient by employing a faster cooling rate will be greatly beneficial for a variety of applications such as laser Q switches, laser pulse shaping, high-speed optical shutters, and modulating retroreflectors. (C) 2013 Optical Society of America C1 [Chang, Yun-Ching; Wang, Chao; Yin, Shizhuo] Penn State Univ, Dept Elect Engn, University Pk, PA 16803 USA. [Hoffman, Robert C.; Mott, Andrew G.] US Army Res Lab, Adelphi, MD 20783 USA. RP Yin, SZ (reprint author), Penn State Univ, Dept Elect Engn, University Pk, PA 16803 USA. EM sxy105@psu.edu FU Army Research Laboratory [W911NF-09-2-0016] FX This research was sponsored by the Army Research Laboratory and was accomplished under Cooperative Agreement No. W911NF-09-2-0016. The views and conclusions contained in this document are those of the authors and should not be interpreted as representing the official policies, either expressed or implied, of the Army Research Laboratory or the U.S. Government. The U.S. Government is authorized to reproduce and distribute reprints for Government purposes notwithstanding any copyright notation hereon. NR 25 TC 24 Z9 24 U1 3 U2 27 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 0146-9592 EI 1539-4794 J9 OPT LETT JI Opt. Lett. PD NOV 15 PY 2013 VL 38 IS 22 BP 4574 EP 4577 DI 10.1364/OL.38.004574 PG 4 WC Optics SC Optics GA 254DB UT WOS:000327142600014 PM 24322077 ER PT J AU Blakely, JN Hahs, DW Corron, NJ AF Blakely, Jonathan N. Hahs, Daniel W. Corron, Ned J. TI Communication waveform properties of an exact folded-band chaotic oscillator SO PHYSICA D-NONLINEAR PHENOMENA LA English DT Article DE Chaos; Communication; On-off keying; Matched filter; Intersymbol interference; Grammar restriction AB We interpret the waveform of an exact folded-band oscillator as an on-off keyed communication waveform. Unlike most nonlinear systems, this oscillator has a general analytic solution that allows for unusually exact analysis. Using this solution, we identify the key differences between a deterministic chaotic oscillation and an ideal on-off keying waveform to be (1) an inherent form of intersymbol interference and (2) a grammar restriction giving rise to a built-in variable length code. We define a simple coherent receiver based on a matched filter, and consider transmission in the presence of additive white Gaussian noise. Analytic expressions for upper and lower bounds on the probability of errors in receiving code letters are derived and shown to be consistent with numerical simulations. Published by Elsevier B.V. C1 [Blakely, Jonathan N.; Corron, Ned J.] US Army Aviat & Missile Res, Charles M Bowden Lab, Dev & Eng Ctr, RDMR WDS WO, Redstone Arsenal, AL 35898 USA. [Hahs, Daniel W.] Torch Technol, Huntsville, AL 35802 USA. RP Blakely, JN (reprint author), US Army Aviat & Missile Res, Charles M Bowden Lab, Dev & Eng Ctr, RDMR WDS WO, Redstone Arsenal, AL 35898 USA. EM jonathan.blakely@us.army.mil; daniel.hahs@us.army.mil; ned.corron@us.army.mil OI Corron, Ned/0000-0002-3232-5024 NR 18 TC 8 Z9 8 U1 0 U2 5 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0167-2789 EI 1872-8022 J9 PHYSICA D JI Physica D PD NOV 15 PY 2013 VL 263 BP 99 EP 106 DI 10.1016/j.physd.2013.08.009 PG 8 WC Mathematics, Applied; Physics, Multidisciplinary; Physics, Mathematical SC Mathematics; Physics GA 246SQ UT WOS:000326559800008 ER PT J AU Kijak, GH Kim, JH AF Kijak, Gustavo H. Kim, Jerome H. TI Timing, Adherence, Resistance, and ... Persistence? New Insight Into the Mechanisms of Failure of HIV Type 1 Postexposure Prophylaxis SO JOURNAL OF INFECTIOUS DISEASES LA English DT Editorial Material DE HIV-1; postexposure prophylaxis; single-genome sequencing; viral sequestration ID HEALTH-CARE WORKERS; FOLLICULAR DENDRITIC CELLS; OCCUPATIONAL EXPOSURE; INFECTION; SEROCONVERSION C1 [Kijak, Gustavo H.; Kim, Jerome H.] US Mil HIV Res Program, Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. [Kijak, Gustavo H.] Henry M Jackson Fdn Adv Mil Med, Bethesda, MD USA. RP Kim, JH (reprint author), US Mil HIV Res Program, Walter Reed Army Inst Res, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM jkim@hivresearch.org NR 21 TC 0 Z9 0 U1 0 U2 1 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0022-1899 EI 1537-6613 J9 J INFECT DIS JI J. Infect. Dis. PD NOV 15 PY 2013 VL 208 IS 10 BP 1542 EP 1544 DI 10.1093/infdis/jit486 PG 3 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 244HI UT WOS:000326378000002 PM 24023256 ER PT J AU McWilliams, BA Yu, JH Yen, CF AF McWilliams, Brandon A. Yu, Jian H. Yen, Chian-Fong TI Numerical simulation and experimental characterization of friction stir welding on thick aluminum alloy AA2139-T8 plates SO MATERIALS SCIENCE AND ENGINEERING A-STRUCTURAL MATERIALS PROPERTIES MICROSTRUCTURE AND PROCESSING LA English DT Article DE Friction stir welding; Aluminum alloys; Constitutive modeling; Finite element analysis ID MECHANICAL-PROPERTIES; MICROSTRUCTURE; PARAMETERS; FLOW AB Friction stir welding (FSW) results in the formation of discrete microstructural zones along the joint of aluminum plates. The ultimate structural integrity of the weld is fundamentally related to the geometry and local mechanical properties of these zones. Numerical models used in engineering design of structures subjected to extreme loading conditions require validated constitutive models capable of accurately describing the complete local deformation behavior at large plastic strains up to and including failure. The present work presents a numerical and experimental study characterizing the mechanical properties of thick ( > 25 mm) aluminum alloy AA 2139-T8 plates that were joined using FSW techniques. A micro-hardness map of the weld is used to determine the geometry of individual weld zones. Micro-tension specimens of each weld zone are individually tested to develop constitutive models which were validated with a tension experiment of the entire weld. In particular, the failure mechanisms through the thickness of the weld and their relation to the microstructural zones that were formed during the FSW process are examined. (C) 2013 Elsevier B.V. All rights reserved. C1 [McWilliams, Brandon A.] Oak Ridge Inst Sci & Educ, Aberdeen Proving Ground, MD 20015 USA. [Yu, Jian H.; Yen, Chian-Fong] US Army, Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 20015 USA. RP McWilliams, BA (reprint author), Oak Ridge Inst Sci & Educ, Aberdeen Proving Ground, MD 20015 USA. EM brandon.a.mcwilliams.ctr@mail.mil; jian.h.yu.ctr@mail.mil; chianfong.yen.civ@mail.mil FU Oak Ridge Institute for Science and Education (ORISE) post-doctoral fellowship at the U.S. Army Research Laboratory FX B. McWilliams acknowledges financial support for this work provided by an Oak Ridge Institute for Science and Education (ORISE) post-doctoral fellowship at the U.S. Army Research Laboratory. NR 26 TC 5 Z9 5 U1 1 U2 40 PU ELSEVIER SCIENCE SA PI LAUSANNE PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND SN 0921-5093 EI 1873-4936 J9 MAT SCI ENG A-STRUCT JI Mater. Sci. Eng. A-Struct. Mater. Prop. Microstruct. Process. PD NOV 15 PY 2013 VL 585 BP 243 EP 252 DI 10.1016/j.msea.2013.07.073 PG 10 WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Science & Technology - Other Topics; Materials Science; Metallurgy & Metallurgical Engineering GA 241CF UT WOS:000326143300030 ER PT J AU Sarney, WL Svensson, SP Novikov, SV Yu, KM Walukiewicz, W Foxon, CT AF Sarney, W. L. Svensson, S. P. Novikov, S. V. Yu, K. M. Walukiewicz, W. Foxon, C. T. TI GaN1-xSbx highly mismatched alloys grown by low temperature molecular beam epitaxy under Ga-rich conditions SO JOURNAL OF CRYSTAL GROWTH LA English DT Article DE Crystal structure; Molecular beam epitaxy; Semiconducting III-V materials; Nitrides AB The electronic structure of the conduction and valence bands of highly mismatched alloys (HMAs) such as GaN1-xSbx are well described by the band anticrossing model. The properties of this alloy, which has a large band gap range and controllable valence band positions, make it a candidate material for efficient solar energy conversion devices. We have examined the growth and structural properties of amorphous and crystalline GaN1-xSbx. These HMAs were grown by low temperature molecular beam epitaxy (MBE) under Ga-rich conditions. While there is a monotonic linear increase of Sb incorporation with Sb overpressure, there was no obvious dependence of Sb incorporation with growth temperature for the range of 10-470 degrees C. At growth temperatures lower than 100 degrees C, GaN1-xSx HMAs lose crystallinity and become amorphous for Sb compositions at or exceeding similar to 5%. Ga-rich growth resulted in strong absorption at energies as low as 1 eV for GaN1-xSbx alloys of all compositions. The strong low energy absorption may arise from a Ga-related defect band. Published by Elsevier B.V. C1 [Sarney, W. L.; Svensson, S. P.] US Army Res Lab, Adelphi, MD 20783 USA. [Novikov, S. V.; Foxon, C. T.] Univ Nottingham, Sch Phys & Astron, Nottingham NG7 2RD, England. [Yu, K. M.; Walukiewicz, W.] Univ Calif Berkeley, Lawrence Berkeley Natl Lab, Div Mat Sci, Berkeley, CA 94720 USA. RP Sarney, WL (reprint author), US Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM wendy.l.sarney.civ@mail.mil OI Yu, Kin Man/0000-0003-1350-9642 FU Office of Science, Office of Basic Energy Sciences, Materials Sciences and Engineering Division, of the U.S. Department of Energy [DE-AC02-05CH11231]; Engineering and Physical Sciences Research Council (EPSRC); U.S. Army Foreign Technology Assessment Support (FTAS) program FX RBS and optical measurements performed at Lawrence Berkeley National Lab were supported by the Director, Office of Science, Office of Basic Energy Sciences, Materials Sciences and Engineering Division, of the U.S. Department of Energy under Contract No. DE-AC02-05CH11231.; The MBE growth at the University of Nottingham was undertaken with support from the Engineering and Physical Sciences Research Council (EPSRC) and the U.S. Army Foreign Technology Assessment Support (FTAS) program. NR 11 TC 8 Z9 8 U1 1 U2 14 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0022-0248 EI 1873-5002 J9 J CRYST GROWTH JI J. Cryst. Growth PD NOV 15 PY 2013 VL 383 BP 95 EP 99 DI 10.1016/j.jcrysgro.2013.08.030 PG 5 WC Crystallography; Materials Science, Multidisciplinary; Physics, Applied SC Crystallography; Materials Science; Physics GA 239TR UT WOS:000326049000016 ER PT J AU Svenkeson, A Beig, MT Turalska, M West, BJ Grigolini, P AF Svenkeson, A. Beig, M. T. Turalska, M. West, B. J. Grigolini, P. TI Fractional trajectories: Decorrelation versus friction SO PHYSICA A-STATISTICAL MECHANICS AND ITS APPLICATIONS LA English DT Article DE Fractional calculus; Subordination; Mittag-Leffler; Nonlinear operator; Decorrelation; Relaxation to equilibrium ID ANOMALOUS DIFFUSION; LANGEVIN-EQUATIONS; LEVY FLIGHTS; RANDOM-WALKS; CALCULUS; MODEL; OSCILLATOR; DYNAMICS; VOLTERRA; ORDER AB The fundamental connection between fractional calculus and subordination processes is explored and affords a physical interpretation of a fractional trajectory, that being an average over an ensemble of stochastic trajectories. Heretofore what has been interpreted as intrinsic friction, a form of non-Markovian dissipation that automatically arises from adopting the fractional calculus, is shown to be a manifestation of decorrelations between trajectories. We apply the general theory developed herein to the Lotka-Volterra ecological model, providing new insight into the final equilibrium state. The relaxation time to achieve this state is also considered. (C) 2013 Elsevier B.V. All rights reserved. C1 [Svenkeson, A.; Beig, M. T.; Grigolini, P.] Univ N Texas, Ctr Nonlinear Sci, Denton, TX 76203 USA. [Turalska, M.; West, B. J.] Duke Univ, Dept Phys, Durham, NC 27708 USA. [West, B. J.] Army Res Off, Informat Sci Directorate, Res Triangle Pk, NC 27709 USA. RP Svenkeson, A (reprint author), Univ N Texas, Ctr Nonlinear Sci, POB 311427, Denton, TX 76203 USA. EM ajs0259@unt.edu; mirzatanweer@gmail.com; gosiatura@gmail.com; bruce.j.west@att.net; grigo@unt.edu FU Welch [B-1577]; ARO [W911NF-11-1-0478] FX A.S., M.T.B. and P.G. warmly thank Welch and ARO for their support through Grant Nos. B-1577 and W911NF-11-1-0478, respectively. NR 39 TC 6 Z9 6 U1 2 U2 17 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0378-4371 EI 1873-2119 J9 PHYSICA A JI Physica A PD NOV 15 PY 2013 VL 392 IS 22 BP 5663 EP 5672 DI 10.1016/j.physa.2013.07.028 PG 10 WC Physics, Multidisciplinary SC Physics GA 221MK UT WOS:000324662800010 ER PT J AU Motamarri, P Nowak, MR Leiter, K Knap, J Gavini, V AF Motamarri, P. Nowak, M. R. Leiter, K. Knap, J. Gavini, V. TI Higher-order adaptive finite-element methods for Kohn-Sham density functional theory SO JOURNAL OF COMPUTATIONAL PHYSICS LA English DT Article DE Real space; Density functional theory; Finite elements; Spectral elements; Higher-order; h-p refinement; Computational efficiency; Convergence; Mesh adaption; Scalability ID ELECTRONIC-STRUCTURE CALCULATIONS; BASIS-SET; CONVERGENCE ACCELERATION; EIGENVALUE PROBLEMS; APPROXIMATIONS; EQUATIONS; MODEL; STATE; MESH; SIMULATION AB We present an efficient computational approach to perform real-space electronic structure calculations using an adaptive higher-order finite-element discretization of Kohn-Sham density-functional theory (DFT). To this end, we develop an a priori mesh-adaption technique to construct a close to optimal finite-element discretization of the problem. We further propose an efficient solution strategy for solving the discrete eigenvalue problem by using spectral finite-elements in conjunction with Gauss-Lobatto quadrature, and a Chebyshev acceleration technique for computing the occupied eigenspace. The proposed approach has been observed to provide a staggering 100-200-fold computational advantage over the solution of a generalized eigenvalue problem. Using the proposed solution procedure, we investigate the computational efficiency afforded by higher-order finite-element discretizations of the Kohn-Sham DFT problem. Our studies suggest that staggering computational savings of the order of 1000-fold relative to linear finite-elements can be realized, for both all-electron and local pseudopotential calculations, by using higher-order finite-element discretizations. On all the benchmark systems studied, we observe diminishing returns in computational savings beyond the sixth-order for accuracies commensurate with chemical accuracy, suggesting that the hexic spectral-element may be an optimal choice for the finite-element discretization of the Kohn-Sham DFT problem. A comparative study of the computational efficiency of the proposed high-erorder finite-element discretizations suggests that the performance of finite-element basis is competing with the plane-wave discretization for non-periodic local pseudopotential calculations, and compares to the Gaussian basis for all-electron calculations to within an order of magnitude. Further, we demonstrate the capability of the proposed approach to compute the electronic structure of a metallic system containing 1688 atoms using modest computational resources, and good scalability of the present implementation up to 192 processors. (C) 2013 Elsevier Inc. All rights reserved. C1 [Motamarri, P.; Gavini, V.] Univ Michigan, Dept Mech Engn, Ann Arbor, MI 48109 USA. [Nowak, M. R.] Univ Michigan, Dept Elect Engn, Ann Arbor, MI 48109 USA. [Leiter, K.; Knap, J.] US Army Res Labs, Aberdeen Proving Ground, MD 21001 USA. RP Gavini, V (reprint author), Univ Michigan, Dept Mech Engn, Ann Arbor, MI 48109 USA. EM vikramg@umich.edu RI Gavini, Vikram/J-9725-2012 OI Gavini, Vikram/0000-0002-9451-2300 FU National Science Foundation [1053145, OCI-1053575]; Army Research Office [W911NF-09-0292]; Air Force Office of Scientific Research [FA9550-09-1-0240, FA9550-13-1-0113]; Alexander von Humboldt Foundation FX We thank Dr. John Pask at Lawrence Livermore National Laboratory for the many useful discussions on this work. We gratefully acknowledge the support of National Science Foundation under Grant No. 1053145 and the Army Research Office under Grant No. W911NF-09-0292. V.G. also gratefully acknowledges the support of Air Force Office of Scientific Research under Grant Nos. FA9550-09-1-0240 and FA9550-13-1-0113 under the auspices of which part of the computational framework was developed. V.G. also acknowledges the Alexander von Humboldt Foundation through a research fellowship, and is grateful to the hospitality of the Max-Planck Institute for Mathematics in Sciences and the Institute of Applied Mechanics at University of Stuttgart while completing this work. This work used the Extreme Science and Engineering Discovery Environment (XSEDE), which is supported by National Science Foundation grant number OCI-1053575. NR 76 TC 23 Z9 24 U1 1 U2 27 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0021-9991 EI 1090-2716 J9 J COMPUT PHYS JI J. Comput. Phys. PD NOV 15 PY 2013 VL 253 BP 308 EP 343 DI 10.1016/j.jcp.2013.06.042 PG 36 WC Computer Science, Interdisciplinary Applications; Physics, Mathematical SC Computer Science; Physics GA 207OG UT WOS:000323610500017 ER PT J AU Lennon, E Farr, J Sesser, R AF Lennon, Elizabeth Farr, John Sesser, Ronald TI Evaluation of multi-attribute decision making systems applied during the concept design of new microplasma devices SO EXPERT SYSTEMS WITH APPLICATIONS LA English DT Article DE Multi-attribute decision making; Engineering design; Design process(es); Concept design tools; New product development ID QUALITY FUNCTION DEPLOYMENT; MICROCAVITY PLASMA-DEVICES; AXIOMATIC DESIGN; ENGINEERING DESIGN; CONCEPT SELECTION; HIERARCHY PROCESS; DISCHARGE; ARRAYS AB Various multi-attribute decision making (MADM) systems can be implemented to narrow a field of new concept designs down to those with high likelihoods of surpassing state-of-the-art technologies. This research investigated the conceptual design phase of new microplasma devices in order to create metrics that evaluate the efficiency, effectiveness, and overall utility of representative MADM systems studied in previous engineering design applications. Device attributes and concept alternatives for the microplasma devices were identified from open-ended expert surveys. Efficiency metrics were defined based on the number of manual user inputs. Published device literature and testing were used to gauge how closely device concepts satisfied multi-attribute criteria, forming the basis of an effectiveness metric. A weighted average of the efficiency and effectiveness defined a MADM system's overall utility. Varying the effectiveness weight provided further insight into the conditions under which particular MADM approaches exhibited higher utility values. The MADM systems found to possess the highest overall quantified utilities were based on Pugh's controlled convergence, Utility Based Axiomatic Framework, and Grey Relational Analysis. The MADM method with the lowest overall utility was the analytical hierarchy process. These findings indicate that consensus building and utility-based MADM systems are especially helpful to engineering design teams during the early design phases of novel technologies when resources are constrained or historical data is limited. (c) 2013 Elsevier Ltd. All rights reserved. C1 [Lennon, Elizabeth; Sesser, Ronald] Stevens Inst Technol, Dept Chem Engn & Mat Sci, Hoboken, NJ 07030 USA. [Lennon, Elizabeth] Stevens Inst Technol, Dept Syst Engn, Hoboken, NJ 07030 USA. [Farr, John] US Mil Acad, Dept Syst Engn, West Point, NY 10996 USA. RP Lennon, E (reprint author), Stevens Inst Technol, Hoboken, NJ 07030 USA. EM elennon@stevens.edu FU US Office of Naval Research [000140-81-04-0-3]; School of Systems and Enterprises; Stanley Fellowship Program at Stevens Institute of Technology; National Science Foundation [ECS-0335765]; Army Research Office [W911NF-07-1-0118] FX The authors gratefully acknowledge the University Laboratory Initiative Program administered by the US Office of Naval Research as the primary sponsor of this research effort (Grant 000140-81-04-0-3). Special thanks are extended to the School of Systems and Enterprises and the Stanley Fellowship Program at Stevens Institute of Technology for helping support this study as well. We thank the Cornell NanoScale Facility, a member of the National Nanotechnology Infrastructure Network, which is supported by the National Science Foundation (Grant ECS-0335765). We acknowledge the Army Research Office (Grant W911NF-07-1-0118) for contributing resources for the fabrication of the novel MHCDt devices. The authors are also grateful for the contributions of Peter Lindner and Anthony Najem. NR 54 TC 5 Z9 7 U1 0 U2 41 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0957-4174 J9 EXPERT SYST APPL JI Expert Syst. Appl. PD NOV 15 PY 2013 VL 40 IS 16 BP 6321 EP 6329 DI 10.1016/j.eswa.2013.05.049 PG 9 WC Computer Science, Artificial Intelligence; Engineering, Electrical & Electronic; Operations Research & Management Science SC Computer Science; Engineering; Operations Research & Management Science GA 197NF UT WOS:000322857200011 ER PT J AU Hood, MA Gold, CS Beyer, FL Sands, JM Li, CY AF Hood, Matthew A. Gold, Christopher S. Beyer, Frederick L. Sands, James M. Li, Christopher Y. TI Extraordinarily high plastic deformation in polyurethane/silica nanoparticle nanocomposites with low filler concentrations SO POLYMER LA English DT Article DE Polymer nanocomposite; Polymer crystallization; Polyurethane ID CARBON NANOTUBE NANOCOMPOSITES; POLYMER SINGLE-CRYSTAL; X-RAY-SCATTERING; CRYSTALLIZATION BEHAVIOR; NANOCLAY NANOCOMPOSITES; SEGMENTED POLYURETHANES; SILICA NANOCOMPOSITES; MORPHOLOGY; REINFORCEMENT; ELASTOMER AB We have synthesized segmented polyurethane (SPU)/silica nanoparticle (SiNP) nanocomposites with extraordinarily high tensile strength and strain-at-break using an in-situ polymerization method with low SiNP concentrations. A 20-fold increase in strain-at-break compared with the pristine polymer has been achieved for the 0.5 wt% SiNP nanocomposites. A suite of characterization tools including transmission electron microscopy, ultra-small angle X-ray scattering, X-ray diffraction, differential scanning calorimetry and thermogravimetric analysis has been used to correlate the phase morphology, crystallization, and mechanical properties. The location of SiNP in the phase separated SPU is believed to be the main reason for the mechanical property enhancement. (C) 2013 Elsevier Ltd. All rights reserved. C1 [Hood, Matthew A.; Li, Christopher Y.] Drexel Univ, Dept Mat Sci & Engn, Philadelphia, PA 19104 USA. [Gold, Christopher S.; Beyer, Frederick L.; Sands, James M.] Army Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Li, CY (reprint author), Drexel Univ, Dept Mat Sci & Engn, Philadelphia, PA 19104 USA. EM chrisli@drexel.edu RI Li, Christopher/A-1603-2012 FU Drexel University Koerner Family Fellowship; US Army Research Laboratory [W911NF-06-2-0013]; National Science Foundation [CMMI-1100166]; Oak Ridge Institute for Science and Education; U.S. Department of Energy and USARL; National Science Foundation/Department of Energy [NSF/CHE-0822838]; U.S. Department of Energy, Office of Science, Office of Basic Energy Sciences [DE-AC02-06CH11357] FX We would like to thank the Drexel University Koerner Family Fellowship, the US Army Research Laboratory (Contract W911NF-06-2-0013), and the National Science Foundation (CMMI-1100166) for financial support. CSG was supported in part by the Oak Ridge Institute for Science and Education through an interagency agreement between the U.S. Department of Energy and USARL. ChemMatCARS Sector 15 is principally supported by the National Science Foundation/Department of Energy under grant number NSF/CHE-0822838. Use of the Advanced Photon Source was supported by the U.S. Department of Energy, Office of Science, Office of Basic Energy Sciences, under Contract No. DE-AC02-06CH11357. WAXD and TEM experiments were carried out at Drexel's Centralized Research Facility. NR 42 TC 11 Z9 12 U1 2 U2 28 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0032-3861 EI 1873-2291 J9 POLYMER JI Polymer PD NOV 14 PY 2013 VL 54 IS 24 BP 6510 EP 6515 DI 10.1016/j.polymer.2013.10.010 PG 6 WC Polymer Science SC Polymer Science GA 250KG UT WOS:000326851100002 ER PT J AU Ruiz-Lopez, F Wilkerson, RC Ponsonby, DJ Herrera, M Sallum, MAM Velez, ID Quinones, ML Flores-Mendoza, C Chadee, DD Alarcon, J Alarcon-Ormasa, J Linton, YM AF Ruiz-Lopez, Freddy Wilkerson, Richard C. Ponsonby, David J. Herrera, Manuela Mureb Sallum, Maria Anice Dario Velez, Ivan Quinones, Martha L. Flores-Mendoza, Carmen Chadee, Dave D. Alarcon, Joubert Alarcon-Ormasa, Joubert Linton, Yvonne-Marie TI Systematics of the Oswaldoi Complex (Anopheles, Nyssorhynchus) in South America SO PARASITES & VECTORS LA English DT Article DE Anopheles oswaldoi species complex; An. oswaldoi s. s.; An. oswaldoi A; An. oswaldoi B; An. sp nr. konderi; COI barcoding; ITS2 ID INTERNAL TRANSCRIBED SPACER; SENSU-LATO DIPTERA; MALARIA VECTOR; PLASMODIUM-VIVAX; RIBOSOMAL DNA; COMPARATIVE SUSCEPTIBILITY; AMAZON REGION; INTRAGENOMIC HETEROGENEITY; PHYLOGENETIC-RELATIONSHIPS; MOLECULAR DIFFERENTIATION AB Background: Effective malaria control relies on accurate identification of those Anopheles mosquitoes responsible for the transmission of Plasmodium parasites. Anopheles oswaldoi s.l. has been incriminated as a malaria vector in Colombia and some localities in Brazil, but not ubiquitously throughout its Neotropical range. This evidence together with variable morphological characters and genetic differences supports that An. oswaldoi s.l. compromises a species complex. The recent fully integrated redescription of An. oswaldoi s.s. provides a solid taxonomic foundation from which to molecularly determine other members of the complex. Methods: DNA sequences of the Second Internal Transcribed Spacer (ITS2 - rDNA) (n = 192) and the barcoding region of the Cytochrome Oxidase I gene (COI - mtDNA) (n = 110) were generated from 255 specimens of An. oswaldoi s.l. from 33 localities: Brazil (8 localities, including the lectotype series of An. oswaldoi), Ecuador (4), Colombia (17), Trinidad and Tobago (1), and Peru (3). COI sequences were analyzed employing the Kimura-two-parameter model (K2P), Bayesian analysis (MrBayes), Mixed Yule-Coalescent model (MYC, for delimitation of clusters) and TCS genealogies. Results: Separate and combined analysis of the COI and ITS2 data sets unequivocally supported four separate species: two previously determined (An. oswaldoi s.s. and An. oswaldoi B) and two newly designated species in the Oswaldoi Complex (An. oswaldoi A and An. sp. nr. konderi). The COI intra-and inter-specific genetic distances for the four taxa were non-overlapping, averaging 0.012 (0.007 to 0.020) and 0.052 (0.038 to 0.064), respectively. The concurring four clusters delineated by MrBayes and MYC, and four independent TCS networks, strongly confirmed their separate species status. In addition, An. konderi of Sallum should be regarded as unique with respect to the above. Despite initially being included as an outgroup taxon, this species falls well within the examined taxa, suggesting a combined analysis of these taxa would be most appropriate. Conclusions: Through novel data and retrospective comparison of available COI and ITS2 DNA sequences, evidence is shown to support the separate species status of An. oswaldoi s.s., An. oswaldoi A and An. oswaldoi B, and at least two species in the closely related An. konderi complex (An. sp. nr. konderi, An. konderi of Sallum). Although An. oswaldoi s.s. has never been implicated in malaria transmission, An. oswaldoi B is a confirmed vector and the new species An. oswaldoi A and An. sp. nr. konderi are circumstantially implicated, most likely acting as secondary vectors. C1 [Ruiz-Lopez, Freddy; Wilkerson, Richard C.] Museum Support Ctr, Smithsonian Inst, Natl Museum Nat Hist, Dept Entomol, Suitland, MD 20746 USA. [Ruiz-Lopez, Freddy; Dario Velez, Ivan] Univ Antioquia, Fac Med, Programa Estudio & Control Enfermedades Trop, Medellin, Colombia. [Wilkerson, Richard C.; Linton, Yvonne-Marie] Museum Support Ctr, Smithsonian Inst, Walter Reed Biosyst Unit, Suitland, MD 20746 USA. [Ponsonby, David J.] Canterbury Christ Church Univ, Dept Geog & Life Sci, Kent, OH USA. [Herrera, Manuela; Quinones, Martha L.] Univ Nacl Colombia, Fac Med, Bogota, Colombia. [Mureb Sallum, Maria Anice] Univ Sao Paulo, Fac Saude Publ, Dept Epidemiol, BR-01255 Sao Paulo, Brazil. [Flores-Mendoza, Carmen] Naval Med Res Unit NAMRU 6, Lima, Peru. [Chadee, Dave D.] Univ W Indies, Fac Sci & Technol, Dept Life Sci, West Indies, Trinid & Tobago. [Alarcon, Joubert; Alarcon-Ormasa, Joubert] Minist Salud Publ, Serv Nacl Control Enfermedades Transmitidas Vecto, Guayaquil, Ecuador. [Linton, Yvonne-Marie] Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. RP Ruiz-Lopez, F (reprint author), Museum Support Ctr, Smithsonian Inst, Natl Museum Nat Hist, Dept Entomol, Suitland, MD 20746 USA. EM fredyruiz9@gmail.com RI Sallum, Maria/B-8537-2012 FU UNICEF/UNDP/World Bank/WHO Special Programme for Research and Training in Tropical Diseases (TDR) [A50252]; Canterbury Christ Church University; Friends of the Natural History Museum, London; Mosquito Barcoding Initiative; Barcode of Life (CBOL); Sloane Foundation; National Institute of Health (NIH), USA [2R01AI054139]; COLCIENCIAS [110134319196] FX This study formed part of the PhD study of FRL conducted at the Natural History Museum, London, and awarded from Canterbury Christ Church University, Canterbury, Kent, U. K. This investigation received financial support from the UNICEF/UNDP/World Bank/WHO Special Programme for Research and Training in Tropical Diseases (TDR) (grant A50252 to YML), Canterbury Christ Church University (studentship to FRL). Additional funding was obtained through the Friends of the Natural History Museum, London to further the activities of the Mosquito Barcoding Initiative (to YML); the Consortium for the Barcode of Life (CBOL) ( to YML and RCW) and the Sloane Foundation (to YML and RCW); the National Institute of Health (NIH), USA (grant 2R01AI054139 to Jan E. Conn) and COLCIENCIAS (grant 110134319196 to MLQ). We thank Dr. A. Papadopoulou for help with the MYC analysis and Dr. S. Mahamdallie for helpful suggestions and discussions during preparation of the manuscript. NR 62 TC 8 Z9 8 U1 0 U2 7 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1756-3305 J9 PARASITE VECTOR JI Parasites Vectors PD NOV 12 PY 2013 VL 6 AR 324 DI 10.1186/1756-3305-6-324 PG 13 WC Parasitology SC Parasitology GA 277PX UT WOS:000328832800001 PM 24499562 ER PT J AU Cheng, YW Zhang, HB Varanasi, CV Liu, J AF Cheng, Yingwen Zhang, Hongbo Varanasi, Chakrapani V. Liu, Jie TI Highly Efficient Oxygen Reduction Electrocatalysts based on Winged Carbon Nanotubes SO SCIENTIFIC REPORTS LA English DT Article ID NITROGEN-DOPED GRAPHENE; FUEL-CELL; VISIBLE-LIGHT; CATALYST; OXIDE; NANOCRYSTALS; DURABILITY; SUPPORT AB Developing electrocatalysts with both high selectivity and efficiency for the oxygen reduction reaction (ORR) is critical for several applications including fuel cells and metal-air batteries. In this work we developed high performance electrocatalysts based on unique winged carbon nanotubes. We found that the outer-walls of a special type of carbon nanotubes/nanofibers, when selectively oxidized, unzipped and exfoliated, form graphene wings strongly attached to the inner tubes. After doping with nitrogen, the winged nanotubes exhibited outstanding activity toward catalyzing the ORR through the four-electron pathway with excellent stability and methanol/carbon monoxide tolerance. While the doped graphene wings with high active site density bring remarkable catalytic activity, the inner tubes remain intact and conductive to facilitate electron transport during electrocatalysis. C1 [Cheng, Yingwen; Zhang, Hongbo; Varanasi, Chakrapani V.; Liu, Jie] Duke Univ, Dept Chem, Durham, NC 27708 USA. [Cheng, Yingwen; Liu, Jie] Duke Univ, Ctr Environm Implicat NanoTechnol CEINT, Durham, NC 27708 USA. [Varanasi, Chakrapani V.] Army Res Off, Res Triangle Pk, NC 27703 USA. RP Liu, J (reprint author), Duke Univ, Dept Chem, Durham, NC 27708 USA. EM j.liu@duke.edu RI Cheng, Yingwen/B-2202-2012; Liu, Jie/B-4440-2010 OI Cheng, Yingwen/0000-0002-0778-5504; Liu, Jie/0000-0003-0451-6111 FU Army Research Office (ARO) [W911NF-04-D-0001]; National Science Foundation (NSF); Environmental Protection Agency (EPA) under NSF [EF-0830093]; Duke SMIF (Shared Materials Instrumentation Facilities) FX This work is supported by Army Research Office (ARO) under contract W911NF-04-D-0001, the National Science Foundation (NSF) and the Environmental Protection Agency (EPA) under NSF Cooperative Agreement EF-0830093, Center for the Environmental Implications of NanoTechnology (CEINT). Any opinions, findings, conclusions or recommendations expressed in this material are those of the author(s) and do not necessarily reflect the views of the ARO, NSF or the EPA. This work has not been subjected to EPA review and no official endorsement should be inferred. The authors also acknowledge the support from Duke SMIF (Shared Materials Instrumentation Facilities). NR 30 TC 20 Z9 20 U1 3 U2 64 PU NATURE PUBLISHING GROUP PI LONDON PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND SN 2045-2322 J9 SCI REP-UK JI Sci Rep PD NOV 12 PY 2013 VL 3 AR 3195 DI 10.1038/srep03195 PG 5 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 252PJ UT WOS:000327019200007 PM 24217312 ER PT J AU Choi, KK Jhabvala, MD Sun, J Jhabvala, CA Waczynski, A Olver, K AF Choi, K. K. Jhabvala, M. D. Sun, J. Jhabvala, C. A. Waczynski, A. Olver, K. TI Resonator-quantum well infrared photodetectors SO APPLIED PHYSICS LETTERS LA English DT Article AB We applied a recent electromagnetic model to design the resonator-quantum well infrared photodetector (R-QWIP). In this design, we used an array of rings as diffractive elements to diffract normal incident light into parallel propagation and used the pixel volume as a resonator to intensify the diffracted light. With a proper pixel size, the detector resonates at certain optical wavelengths and thus yields a high quantum efficiency (QE). To test this detector concept, we fabricated a number of R-QWIPs with different quantum well materials and detector geometries. The experimental result agrees satisfactorily with the prediction, and the highest QE achieved is 71%. C1 [Choi, K. K.; Sun, J.; Olver, K.] US Army Res Lab, Electopt & Photon Div, Adelphi, MD 20783 USA. [Jhabvala, M. D.; Jhabvala, C. A.; Waczynski, A.] NASA, Goddard Space Flight Ctr, Instrument Syst & Technol Div, Greenbelt, MD 20771 USA. RP Choi, KK (reprint author), US Army Res Lab, Electopt & Photon Div, Adelphi, MD 20783 USA. EM kwong.k.choi.civ@mail.mil NR 11 TC 10 Z9 10 U1 0 U2 38 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0003-6951 EI 1077-3118 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD NOV 11 PY 2013 VL 103 IS 20 AR 201113 DI 10.1063/1.4831797 PG 4 WC Physics, Applied SC Physics GA 263OU UT WOS:000327818700013 ER PT J AU Gosi, P Lanteri, CA Tyner, SD Se, Y Lon, C Spring, M Char, M Sea, D Sriwichai, S Surasri, S Wongarunkochakorn, S Pidtana, K Walsh, DS Fukuda, MM Manning, J Saunders, DL Bethell, D AF Gosi, Panita Lanteri, Charlotte A. Tyner, Stuart D. Se, Youry Lon, Chanthap Spring, Michele Char, Mengchuor Sea, Darapiseth Sriwichai, Sabaithip Surasri, Sittidech Wongarunkochakorn, Saowaluk Pidtana, Kingkan Walsh, Douglas S. Fukuda, Mark M. Manning, Jessica Saunders, David L. Bethell, Delia TI Evaluation of parasite subpopulations and genetic diversity of the msp1, msp2 and glurp genes during and following artesunate monotherapy treatment of Plasmodium falciparum malaria in Western Cambodia SO MALARIA JOURNAL LA English DT Article DE Malaria; Plasmodium falciparum; Cambodia; Genotype; Artesunate; msp1; msp2; glurp ID ANTIMALARIAL CLINICAL-TRIALS; POLYMERASE-CHAIN-REACTION; SOUTHEAST-ASIA; DRUG-TREATMENT; NESTED PCR; POPULATIONS; INFECTIONS; CLEARANCE; RESPONSES; VARIANTS AB Background: Despite widespread coverage of the emergence of artemisinin resistance, relatively little is known about the parasite populations responsible. The use of PCR genotyping around the highly polymorphic Plasmodium falciparum msp1, msp2 and glurp genes has become well established both to describe variability in alleles within a population of parasites, as well as classify treatment outcome in cases of recurrent disease. The primary objective was to assess the emergence of minority parasite clones during seven days of artesunate (AS) treatment in a location with established artemisinin resistance. An additional objective was to investigate whether the classification of clinical outcomes remained valid when additional genotyping was performed. Methods: Blood for parasite genotyping was collected from 143 adult patients presenting with uncomplicated falciparum malaria during a clinical trial of AS monotherapy in Western Cambodia. Nested allelic type-specific amplification of the genes encoding the merozoite surface proteins 1 and 2 (msp1 and msp2) and the glutamate-rich protein (glurp) was performed at baseline, daily during seven days of treatment, and again at failure. Allelic variants were analysed with respect to the size of polymorphisms using Quantity One software to enable identification of polyclonal infections. Results: Considerable variation of msp2 alleles but well-conserved msp1 and glurp were identified. At baseline, 31% of infections were polyclonal for one or more genes. Patients with recurrent malaria were significantly more likely to have polyclonal infections than patients without recurrence (seven of nine versus 36 of 127, p = 0.004). Emergence of minority alleles during treatment was detected in only one of twenty-three cases defined as being artemisinin resistant. Moreover, daily genotyping did not alter the final outcome classification in any recurrent cases. Conclusions: The parasites responsible for artemisinin-resistant malaria in a clinical trial in Western Cambodia comprise the dominant clones of acute malaria infections rather than minority clones emerging during treatment. Additional genotyping during therapy was not beneficial. Disproportionately high rates of polyclonal infections in cases of recurrence suggest complex infections lead to poor treatment outcomes. Current research objectives should be broadened to include identification and follow-up of recurrent polyclonal infections so as to define their role as potential agents of emerging resistance. C1 [Gosi, Panita; Lanteri, Charlotte A.; Tyner, Stuart D.; Spring, Michele; Sriwichai, Sabaithip; Surasri, Sittidech; Wongarunkochakorn, Saowaluk; Pidtana, Kingkan; Walsh, Douglas S.; Fukuda, Mark M.; Manning, Jessica; Saunders, David L.; Bethell, Delia] Armed Forces Res Inst Med Sci, Dept Immunol & Med, Bangkok 10400, Thailand. [Se, Youry; Lon, Chanthap; Sea, Darapiseth] Armed Forces Res Inst Med Sci, Phnom Penh, Cambodia. [Char, Mengchuor] Natl Ctr Parasitol Entomol & Malaria Control, Phnom Penh, Cambodia. RP Bethell, D (reprint author), Armed Forces Res Inst Med Sci, Dept Immunol & Med, Bangkok 10400, Thailand. EM delia.bethell@afrims.org NR 31 TC 14 Z9 16 U1 0 U2 0 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1475-2875 J9 MALARIA J JI Malar. J. PD NOV 9 PY 2013 VL 12 AR 403 DI 10.1186/1475-2875-12-403 PG 13 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA 281LZ UT WOS:000329104400001 PM 24206588 ER PT J AU Theberge, S Semlali, A Alamri, A Leung, KP Rouabhia, M AF Theberge, Simon Semlali, Abdelhabib Alamri, Abdullah Leung, Kai P. Rouabhia, Mahmoud TI C-albicans growth, transition, biofilm formation, and gene expression modulation by antimicrobial decapeptide KSL-W SO BMC MICROBIOLOGY LA English DT Article DE Antimicrobial peptide; KSL-W; C. albicans; Growth; Hyphae; Gene; EFG1; NRG1; HWP1; SAPs ID SECRETED ASPARTYL PROTEINASES; INNATE IMMUNITY; IN-VITRO; PEPTIDES; VIRULENCE; MORPHOGENESIS; REGULATOR; NRG1; BETA-DEFENSIN-3; PLEUROCIDIN AB Background: Antimicrobial peptides have been the focus of much research over the last decade because of their effectiveness and broad-spectrum activity against microbial pathogens. These peptides also participate in inflammation and the innate host defense system by modulating the immune function that promotes immune cell adhesion and migration as well as the respiratory burst, which makes them even more attractive as therapeutic agents. This has led to the synthesis of various antimicrobial peptides, including KSL-W (KKW Gamma WVK Gamma K-NH2), for potential clinical use. Because this peptide displays antimicrobial activity against bacteria, we sought to determine its antifungal effect on C. albicans. Growth, hyphal form, biofilm formation, and degradation were thus examined along with EFG1, NRG1, EAP1, HWP1, and SAP 2-4-5-6 gene expression by quantitative RT-PCR. Results: This study demonstrates that KSL-W markedly reduced C. albicans growth at both early and late incubation times. The significant effect of KSL-W on C. albicans growth was observed beginning at 10 mu g/ml after 5 h of contact by reducing C. albicans transition and at 25 mu g/ml by completely inhibiting C. albicans transition. Cultured C. albicans under biofilm-inducing conditions revealed that both KSL-W and amphotericin B significantly decreased biofilm formation at 2, 4, and 6 days of culture. KSL W also disrupted mature C. albicans biofilms. The effect of KSL W on C. albicans growth, transition, and biofilm formation/disruption may thus occur through gene modulation, as the expression of various genes involved in C. albicans growth, transition and biofilm formation were all downregulated when C. albicans was treated with KSL-W. The effect was greater when C. albicans was cultured under hyphae-inducing conditions. Conclusions: These data provide new insight into the efficacy of KSL-W against C. albicans and its potential use as an antifungal therapy. C1 [Theberge, Simon; Semlali, Abdelhabib; Alamri, Abdullah; Rouabhia, Mahmoud] Univ Laval, Oral Ecol Res Grp, Fac Dent, Quebec City, PQ G1V 0A6, Canada. [Semlali, Abdelhabib] King Saud Univ, Coll Sci, Dept Biochem, Genome Res Chair, Riyadh 11451, Saudi Arabia. [Leung, Kai P.] JBSA Ft Sam Houston, Dental & Trauma Res Detachment, US Army Inst Surg Res, San Antonio, TX USA. RP Rouabhia, M (reprint author), Univ Laval, Oral Ecol Res Grp, Fac Dent, 2420 Rue Terrasse, Quebec City, PQ G1V 0A6, Canada. EM mahmoud.rouabhia@fmd.ulaval.ca FU United States Army Medical Research and Materiel Command (ERMS) [12304006]; Universite Laval foundation FX This study was supported financially by the United States Army Medical Research and Materiel Command (Award number ERMS No. 12304006) and by a grant from the Fonds Emile-Beaulieu, a Universite Laval foundation. The authors also thank Ms. Claire Kingston (Traduction CFK) for proofreading and editing this manuscript. NR 65 TC 14 Z9 15 U1 0 U2 7 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1471-2180 J9 BMC MICROBIOL JI BMC Microbiol. PD NOV 7 PY 2013 VL 13 AR 246 DI 10.1186/1471-2180-13-246 PG 14 WC Microbiology SC Microbiology GA 277YB UT WOS:000328854100001 PM 24195531 ER PT J AU Prokopenko, OV Krivorotov, IN Bankowski, EN Meitzler, TJ Tiberkevich, VS Slavin, AN AF Prokopenko, O. V. Krivorotov, I. N. Bankowski, E. N. Meitzler, T. J. Tiberkevich, V. S. Slavin, A. N. TI Hysteresis regime in the operation of a dual-free-layer spin-torque nano-oscillator with out-of-plane counter-precessing magnetic moments SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID POLARIZED CURRENT; PHASE-LOCKING; MICROWAVE GENERATION; DRIVEN; WAVES; EMISSION; DYNAMICS; DEVICES AB We studied the operation of a dual-free-layer (DFL) spin-torque nano-oscillator (STNO) and demonstrated that in a practically interesting regime when the magnetizations of the two free layers (FLs) precess in opposite directions along large-angle out-of-plane trajectories, thus doubling the generation frequency, the operation of the DFL STNO is strongly hysteretic as a function of a bias dc current. The stable magnetization dynamics starts at a rather large magnitude of the bias dc current density J(dc) > J(th)(high) when the bias current is increased, but the regime of stable counter-precession of the FLs persists till rather low magnitudes of the bias dc current density J(th)(low) < J(dc) < J(th)(high) when the bias current is decreased. This hysteresis is caused by the dipolar coupling between the FLs, and is especially pronounced for small distances between the FLs and the small magnetic damping in them. The discovered hysteretic behavior of the DFL STNO implies the possibility of application of a strong initial pulse of the bias current (greater than the upper threshold J(th)(high) of the stable dynamics) and subsequent reduction of the bias current to a working point (J(th)(low) < J(dc) < J(th)(high)) corresponding to the required output frequency f(J(dc)). The obtained results are important for the practical development of DFL STNOs with optimized operation characteristics. (c) 2013 AIP Publishing LLC. C1 [Prokopenko, O. V.] Taras Shevchenko Natl Univ Kyiv, Fac Radiophys, UA-01601 Kiev, Ukraine. [Krivorotov, I. N.] Univ Calif Irvine, Dept Phys & Astron, Irvine, CA 92697 USA. [Bankowski, E. N.; Meitzler, T. J.] US Army TARDEC, Dept Ground Syst Survivabil, Warren, MI 48397 USA. [Tiberkevich, V. S.; Slavin, A. N.] Oakland Univ, Dept Phys, Rochester, MI 48309 USA. RP Prokopenko, OV (reprint author), Taras Shevchenko Natl Univ Kyiv, Fac Radiophys, UA-01601 Kiev, Ukraine. EM Oleksandr.Prokopenko@gmail.com RI Tiberkevich, Vasil/A-8697-2008; Meitzler, Thomas/D-1065-2017 OI Tiberkevich, Vasil/0000-0002-8374-2565; FU U.S. Army TARDEC, RDECOM; National Science Foundation of the USA [ECCS-1001815, ECCS-1002358, DMR-1015175, DMR-0748810]; CNFD Grant from the "Semiconductor Research Corporation"; Nanoelectronics Research Initiative through the Western Institute of Nanoelectronics; DARPA MTO/MESO Grant [N66001-11-1-4114]; State Fund for Fundamental Research of Ukraine [UU34/008] FX This work was supported in part by the contract from the U.S. Army TARDEC, RDECOM, by the Grant Nos. ECCS-1001815, ECCS-1002358, DMR-1015175, and DMR-0748810 from the National Science Foundation of the USA, by the CNFD Grant from the "Semiconductor Research Corporation," by the Nanoelectronics Research Initiative through the Western Institute of Nanoelectronics, by the DARPA MTO/MESO Grant N66001-11-1-4114, and by the Grant No. UU34/008 from the State Fund for Fundamental Research of Ukraine. NR 39 TC 3 Z9 3 U1 1 U2 24 PU AMER INST PHYSICS PI MELVILLE PA 1305 WALT WHITMAN RD, STE 300, MELVILLE, NY 11747-4501 USA SN 0021-8979 EI 1089-7550 J9 J APPL PHYS JI J. Appl. Phys. PD NOV 7 PY 2013 VL 114 IS 17 AR 173904 DI 10.1063/1.4828866 PG 9 WC Physics, Applied SC Physics GA 260JU UT WOS:000327591900035 ER PT J AU Creasy, WR McGarvey, DJ Brevett, CAS AF Creasy, William R. McGarvey, David J. Brevett, Carol A. S. TI Speciation of VX in Aqueous Solutions SO JOURNAL OF PHYSICAL CHEMISTRY C LA English DT Article ID P-31 MAS NMR; COUPLING-CONSTANTS; NANOSIZE AL2O3; NERVE AGENTS; HD; GD; DEGRADATION; HYDROLYSIS; CONCRETE; GB AB P-31 and C-13 NMR studies of the toxic chemical warfare agent VX [O-ethyl S-(2-N,N'-(dlisopropylamino)ethyl) methylphosphonothioate] have been used to understand the reactivity in a wide variety of matrices. The presence of protonated VX has been invoked in many mechanisms of VX degradation and decontamination. A change of speciation of VX has been justified by a relatively large shift in the P-31 NMR chemical shift from about 55 ppm (in neat material or organic solvents) to >60 ppm (in aqueous solutions). This study shows that in acetonitrile/water mixtures and in aqueous solutions at a range of pH values, the P-31 NMR resonance was sensitive to the percentage water in the mixture, but was not sensitive to the pH of the solution. This result indicates that the P-31 chemical shift to >60 ppm is not associated with protonated VX, which is only present at pH < 8. However, the C-13 NMR resonances did respond to changes in the pH of the solution, indicating that these shifts are associated with protonation of the VX in acidic media. C1 [Creasy, William R.; Brevett, Carol A. S.] Leidos, Gunpowder Branch, Aberdeen Proving Ground, MD 21010 USA. [McGarvey, David J.] US Army Edgewood Chem Biol Ctr, Res & Technol Directorate, Aberdeen Proving Ground, MD 21010 USA. RP Creasy, WR (reprint author), Leidos, Gunpowder Branch, POB 68, Aberdeen Proving Ground, MD 21010 USA. EM william.r.creasy.ctr@us.army.mil FU DTRA [BA07TAS041, CBS.FATE.01.10.ECB.008]; Science Applications International Corporation (SAIC) [DAAD13-03-D-0017, W911SR-10-D-0004, W911SR-11-C-0047] FX The authors thank Dr. George Wagner for stimulating scientific discussions. W.R.C. thanks Arvin Moser, Joe DiMartino, Irina Oshchepkova, and Scott MacDonald, Advanced Chemistry Development, Inc., for providing information about NMR Predictor software and long-range coupling. This work was supported by DTRA Project Nos. BA07TAS041 and CBS.FATE.01.10.ECB.008, and performed under Science Applications International Corporation (SAIC) Contracts DAAD13-03-D-0017, W911SR-10-D-0004, and W911SR-11-C-0047. The authors thank Messrs. Carroll Cook and Kenneth Sumpter for assistance with the agent operations. NR 23 TC 2 Z9 2 U1 2 U2 44 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1932-7447 J9 J PHYS CHEM C JI J. Phys. Chem. C PD NOV 7 PY 2013 VL 117 IS 44 BP 22677 EP 22682 DI 10.1021/jp409671y PG 6 WC Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary SC Chemistry; Science & Technology - Other Topics; Materials Science GA 250IE UT WOS:000326845400026 ER PT J AU Chromy, BA Eldridge, A Forsberg, JA Brown, TS Kirkup, BC Jaing, C Be, NA Elster, E Luciw, PA AF Chromy, Brett A. Eldridge, Angela Forsberg, Jonathan A. Brown, Trevor S. Kirkup, Benjamin C. Jaing, Crystal Be, Nicholas A. Elster, Eric Luciw, Paul A. TI Wound outcome in combat injuries is associated with a unique set of protein biomarkers SO JOURNAL OF TRANSLATIONAL MEDICINE LA English DT Article DE Traumatic wound; Proteomics; 2-D DIGE; Wound effluent; Biomarker discovery; Wound dehiscence ID ACTIVATED HUMAN PLATELETS; CELLULAR STRESS-RESPONSE; PROTEOMIC ANALYSIS; POSTTRANSLATIONAL MODIFICATIONS; LOWER-EXTREMITY; TISSUE-REPAIR; BLAST INJURY; PHOSPHORYLATION; C3; EXPRESSION AB Background: The ability to forecast whether a wound will heal after closure without further debridement(s), would provide substantial benefits to patients with severe extremity trauma. Methods: Wound effluent is a readily available material which can be collected without disturbing healthy tissue. For analysis of potential host response biomarkers, forty four serial combat wound effluent samples from 19 patients with either healing or failing traumatic-and other combat-related wounds were examined by 2-D DIGE. Spot map patterns were correlated to eventual wound outcome (healed or wound failure) and analyzed using DeCyder 7.0 and differential proteins identified via LC-MS/MS. Results: This approach identified 52 protein spots that were differentially expressed and thus represent candidate biomarkers for this clinical application. Many of these proteins are intimately involved in inflammatory and immune responses. Furthermore, discriminate analysis further refined the 52 differential protein spots to a smaller subset of which successfully differentiate between wounds that will heal and those that will fail and require further surgical intervention with greater than 83% accuracy. Conclusion: These results suggest candidates for a panel of protein biomarkers that may aid traumatic wound care prognosis and treatment. We recommend that this strategy be refined, and then externally validated, in future studies of traumatic wounds. C1 [Chromy, Brett A.; Eldridge, Angela; Luciw, Paul A.] Univ Calif Davis, Sch Med, Dept Pathol & Lab Med, Davis, CA 95616 USA. [Eldridge, Angela; Luciw, Paul A.] Univ Calif Davis, Ctr Comparat Med, Davis, CA 95616 USA. [Forsberg, Jonathan A.] Natl Mil Med Ctr, Dept Orthopaed, Bethesda, MD USA. [Forsberg, Jonathan A.; Brown, Trevor S.] Naval Med Res Ctr, Regenerat Med Dept, Silver Spring, MD USA. [Elster, Eric] Walter Reed Army Inst Res, Dept Wound Infect, Silver Spring, MD USA. [Kirkup, Benjamin C.] Uniformed Serv Univ Hlth Sci, F Edward Hebert Sch Med, Dept Med, Bethesda, MD 20814 USA. [Kirkup, Benjamin C.; Jaing, Crystal; Be, Nicholas A.] Lawrence Livermore Natl Lab, Phys & Life Sci Directorate, Livermore, CA USA. [Forsberg, Jonathan A.; Elster, Eric] Uniformed Serv Univ Hlth Sci, Norman M Rich Dept Surg, Bethesda, MD 20814 USA. RP Chromy, BA (reprint author), Univ Calif Davis, Sch Med, Dept Pathol & Lab Med, Davis, CA 95616 USA. EM brett.chromy@ucdmc.ucdavis.edu RI Brown, Trevor/K-4703-2012; Kirkup, Benjamin/C-3610-2009; Brown, Trevor/F-7392-2015 OI Brown, Trevor/0000-0001-7042-785X; Kirkup, Benjamin/0000-0002-8722-6218; Brown, Trevor/0000-0001-7042-785X FU U.S. Army Medical Research and Materiel Command [MIPR1EO89M1115]; Proteomics Initiative of the Department of Pathology and Laboratory Medicine at U.C. Davis FX The project depicted was sponsored by the U.S. Army Medical Research and Materiel Command (Award number: MIPR1EO89M1115). The U.S. Army Medical Research Acquisition Activity (820 Chandler Street, Fort Detrick MD 21702-5014) is the awarding and administering acquisition office. Partial funding for this project was also provided by the Proteomics Initiative of the Department of Pathology and Laboratory Medicine at U.C. Davis. We gratefully acknowledge Ray Lenhoff for very helpful discussions in the earliest stage of this study. The opinions or assertions contained herein are the private views of the authors, and are not to be construed as official, or as reflecting the position or policy of the government, including the Departments of the Army, Navy, or Defense. NR 33 TC 8 Z9 8 U1 1 U2 11 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1479-5876 J9 J TRANSL MED JI J. Transl. Med. PD NOV 6 PY 2013 VL 11 AR 281 DI 10.1186/1479-5876-11-281 PG 12 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA 285NT UT WOS:000329401400001 PM 24192341 ER PT J AU Wang, YS Creegan, E Felton, M Ligon, D Huynh, G AF Wang, Yansen Creegan, Edward Felton, Melvin Ligon, David Giap Huynh TI Investigation of nocturnal low-level jet-generated gravity waves over Oklahoma City during morning boundary layer transition period using Doppler wind lidar data SO JOURNAL OF APPLIED REMOTE SENSING LA English DT Article DE atmospheric boundary layer; atmospheric low-level jet and wave; boundary layer transition; Doppler wind lidar ID SHEAR-FLOW; TURBULENCE; CLIMATOLOGY; INSTABILITY; INVERSION; CASES-99; MODEL AB Low-level jet (LLJ)-generated gravity waves were observed over Oklahoma City by a scanning Doppler wind lidar during the transition periods of atmospheric boundary layer (ABL) from stable to convective conditions in the mornings after sunrise. The temperature profiles had a multilayer structure with a shallow neutral layer immediately above the ground and a stable cap layer above the neutral layer. The wind profiles exhibited a typical shape of a LLJ with nearly linear growth of wind speed with respect to height, and maximum wind speed occurred at the top of the stable cap layer. The average wavelength and its relation with mean wind and temperature profiles are characterized with data from Doppler wind lidar, radiosonde, and wind profiler. A linear stability analysis was performed to check the stratification conditions for wave occurrence. The wind signals from sonic anemometers near the ground were separated into waves and turbulence parts using a wavelet decomposition method, and the momentum fluxes due to the wave motions and turbulence were computed. The downward gravity wave momentum flux was 1.5 to 3.0 times of turbulent momentum flux. The analysis indicated that gravity wave momentum transport from the stable cap layer downward is one of the mechanisms of stable-to-convective transition in the LLJ-dominated ABL. (C) The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI. C1 [Wang, Yansen; Creegan, Edward; Felton, Melvin; Ligon, David; Giap Huynh] US Army Res Lab, Adelphi, MD 20783 USA. RP Wang, YS (reprint author), US Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM yansen.wang.civ@mail.mil NR 38 TC 2 Z9 2 U1 0 U2 13 PU SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98225 USA SN 1931-3195 J9 J APPL REMOTE SENS JI J. Appl. Remote Sens. PD NOV 5 PY 2013 VL 7 AR 073487 DI 10.1117/1.JRS.7.073487 PG 14 WC Environmental Sciences; Remote Sensing; Imaging Science & Photographic Technology SC Environmental Sciences & Ecology; Remote Sensing; Imaging Science & Photographic Technology GA 245VV UT WOS:000326492800006 ER PT J AU McAninch, IM Palmese, GR Lenhart, JL La Scala, JJ AF McAninch, Ian M. Palmese, Giuseppe R. Lenhart, Joseph L. La Scala, John J. TI Characterization of epoxies cured with bimodal blends of polyetheramines SO JOURNAL OF APPLIED POLYMER SCIENCE LA English DT Article DE thermosets; blends; properties and characterization; glass transition ID MECHANICAL-BEHAVIOR; TOUGHENING MECHANISMS; NETWORK ARCHITECTURE; FRACTURE-TOUGHNESS; PARTICLE-SIZE; RESIN; POLYMERS; DEFORMATION; TEMPERATURE; DENSITY AB DGEBA was cured with bimodal blends of polyetheramines as well as with single molecular weight amines while maintaining stoichiometry. Glass transition temperatures (T(g)s) and moduli were measured using dynamic mechanical analysis (DMA). Fracture properties were measured using the compact tension geometry and testing was performed at both ambient and non-ambient temperatures, investigating toughness changes as a function of temperature. For constant amine average molecular weights, the addition of high molecular weight amines caused increased glassy moduli at a constant T - T-g and decreased densities while broadening the glass transition without changing the fracture toughness. The fracture behavior, specifically the slip-stick to brittle transition, was affected by the broadened transitions. T-g, breadth of T-g, and total damping were found to be proportional to the volume fraction of amine in the system. (c) 2013 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 130: 1621-1631, 2013 C1 [McAninch, Ian M.; La Scala, John J.] ATTN RDRL WMM C, Army Res Lab, Aberdeen Proving Ground, MD 21005 USA. [McAninch, Ian M.; Palmese, Giuseppe R.] Drexel Univ, Dept Chem & Biol Engn, Philadelphia, PA 19104 USA. [Lenhart, Joseph L.] ATTN RDRL WMM G, Army Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP La Scala, JJ (reprint author), ATTN RDRL WMM C, Army Res Lab, Aberdeen Proving Ground, MD 21005 USA. EM john.j.lascala.civ@mail.mil OI McAninch, Ian/0000-0002-9190-2936 FU US Army Research Laboratory under the Army Materials Center of Excellence Program [W911NF-06-2-00]; U.S. Army Research Laboratory; U.S. Department of Energy; USARL FX J. L. L. was the program leader, J. J. L. was the project leader. J. L. L., J. J. L., and G. P. provided guidance on experiment design and interpretation of results. I. M. wrote the manuscript and performed the experiments. G. P., J. J. L., and J. L. L. reviewed and/or edited the manuscript. This research was supported in part by an appointment to the Student Research Participation Program at the U. S. Army Research Laboratory administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the U.S. Department of Energy and USARL. Additional support was provided by the US Army Research Laboratory under the Army Materials Center of Excellence Program, Contract W911NF-06-2-00. NR 42 TC 10 Z9 10 U1 2 U2 45 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0021-8995 J9 J APPL POLYM SCI JI J. Appl. Polym. Sci. PD NOV 5 PY 2013 VL 130 IS 3 BP 1621 EP 1631 DI 10.1002/app.39322 PG 11 WC Polymer Science SC Polymer Science GA 197SR UT WOS:000322871700023 ER PT J AU McClung, JP Martini, S Murphy, NE Montain, SJ Margolis, LM Thrane, I Spitz, MG Blatny, JM Young, AJ Gundersen, Y Pasiakos, SM AF McClung, James P. Martini, Svein Murphy, Nancy E. Montain, Scott J. Margolis, Lee M. Thrane, Ingjerd Spitz, Marissa G. Blatny, Janet-Martha Young, Andrew J. Gundersen, Yngvar Pasiakos, Stefan M. TI Effects of a 7-day military training exercise on inflammatory biomarkers, serum hepcidin, and iron status SO NUTRITION JOURNAL LA English DT Article DE Physical activity; Operational stress; Military; Ferritin; Inflammation; Iron absorption; Soluble transferrin receptor ID PLACEBO-CONTROLLED TRIAL; FEMALE SOLDIERS; DOUBLE-BLIND; DEFICIENCY; ANEMIA; PERFORMANCE; FERRITIN; MARATHON; RUNNERS; WOMEN AB Background: Hepcidin, a peptide that is released into the blood in response to inflammation, prevents cellular iron export and results in declines in iron status. Elevated serum and urinary levels of hepcidin have been observed in athletes following exercise, and declines in iron status have been reported following prolonged periods of training. The objective of this observational study was to characterize the effects of an occupational task, military training, on iron status, inflammation, and serum hepcidin. Findings: Volunteers (n = 21 males) included Norwegian Soldiers participating in a 7-day winter training exercise that culminated in a 3-day, 54 km ski march. Fasted blood samples were collected at baseline, on day 4 (PRE, prior to the ski march), and again on day 7 (POST, following the ski march). Samples were analyzed for hemoglobin, serum ferritin, soluble transferrin receptor (sTfR), interleukin-6 (IL-6), and serum hepcidin. Military training affected inflammation and serum hepcidin levels, as IL-6 and hepcidin concentrations increased (P < 0.05) from the baseline to POST (mean +/- SD, 9.1 +/- 4.9 vs. 14.5 +/- 8.4 pg/mL and 6.5 +/- 3.5 vs. 10.2 +/- 6.9 ng/mL, respectively). Iron status was not affected by the training exercise, as sTfR levels did not change over the course of the 7-day study. Conclusions: Military training resulted in significant elevations in IL-6 and serum hepcidin. Future studies should strive to identify the role of hepcidin in the adaptive response to exercise, as well as countermeasures for the prevention of chronic or repeated elevations in serum hepcidin due to exercise or sustained occupational tasks which may result in longer term decrements in iron status. C1 [McClung, James P.; Murphy, Nancy E.; Montain, Scott J.; Margolis, Lee M.; Young, Andrew J.; Pasiakos, Stefan M.] US Army Res Inst Environm Med, Mil Nutr Div, Natick, MA USA. [Martini, Svein; Thrane, Ingjerd; Blatny, Janet-Martha; Gundersen, Yngvar] Norwegian Def Res Estab, N-2007 Kjeller, Norway. [Spitz, Marissa G.] US Army Res Inst Environm Med, Thermal Mt & Med Div, Natick, MA USA. RP Pasiakos, SM (reprint author), US Army Res Inst Environm Med, Mil Nutr Div, Natick, MA USA. EM stefan.pasiakos@us.army.mil RI McClung, James/A-1989-2009; Pasiakos, Stefan/E-6295-2014; OI Pasiakos, Stefan/0000-0002-5378-5820; , Lee/0000-0002-0652-1304 FU U.S. Army Medical Research and Material Command; Norwegian Defense Research Establishment [W81XWH-12-0279] FX The authors thank the volunteers that participated in this research experiment. The authors acknowledge Holly McClung and Susan McGraw for their significant contributions to ration analysis. This work was supported by the U.S. Army Medical Research and Material Command and the Norwegian Defense Research Establishment, under agreement NO. W81XWH-12-0279. The investigators adhered to the policies for protection of human subjects as prescribed in Army Regulation 70-25, and the research was conducted in adherence with the provisions of 32 CFR part 219. The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the Army or the Department of Defense. Any citations of commercial organizations and trade names in this report do not constitute an official Department of the Army endorsement of approval of the products or services of these organizations. NR 19 TC 9 Z9 9 U1 1 U2 6 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1475-2891 J9 NUTR J JI Nutr. J. PD NOV 4 PY 2013 VL 12 AR 141 DI 10.1186/1475-2891-12-141 PG 4 WC Nutrition & Dietetics SC Nutrition & Dietetics GA 285KW UT WOS:000329393900001 PM 24188143 ER PT J AU Wilhelms, KW Leonard, GT Abadie, JM AF Wilhelms, Kelly W. Leonard, George T. Abadie, Jude M. TI Improving Laboratory Test Ordering Practices in Military Medical Centers SO MILITARY MEDICINE LA English DT Editorial Material ID WORKING GROUP; CANCER C1 [Wilhelms, Kelly W.; Leonard, George T.] Madigan Army Med Ctr, Dept Pathol, Tacoma, WA 98431 USA. [Abadie, Jude M.] Tripler Army Med Ctr, Honolulu, HI 96859 USA. RP Wilhelms, KW (reprint author), Madigan Army Med Ctr, Dept Pathol, 9040 Fitzsimmons Dr, Tacoma, WA 98431 USA. NR 10 TC 0 Z9 0 U1 0 U2 1 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD NOV PY 2013 VL 178 IS 11 BP 1151 EP 1153 DI 10.7205/MILMED-D-13-00168 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA AN7UE UT WOS:000340805700001 PM 24183759 ER PT J AU Bates, MJ Fallesen, JJ Huey, WS Packard, GA Ryan, DM Burke, CS Smith, DG Watola, DJ Pinder, ED Yosick, TM Estrada, AX Crepeau, L Bowles, SV AF Bates, Mark J. Fallesen, Jon J. Huey, Wesley S. Packard, Gary A., Jr. Ryan, Diane M. Burke, C. Shawn Smith, David G. Watola, Daniel J. Pinder, Evette D. Yosick, Todd M. Estrada, Armando X. Crepeau, Loring Bowles, Stephen V. TI Total Force Fitness in Units Part 1: Military Demand-Resource Model SO MILITARY MEDICINE LA English DT Article ID JOB DEMANDS; INTERPERSONAL-COMMUNICATION; ORGANIZATIONAL SUPPORT; ADAPTIVE PERFORMANCE; LEADERSHIP CLIMATE; GOAL ORIENTATION; WORK ENGAGEMENT; SELF-ENGAGEMENT; SOCIAL IDENTITY; TEAM ADAPTATION AB The military unit is a critical center of gravity in the military's efforts to enhance resilience and the health of the force. The purpose of this article is to augment the military's Total Force Fitness (TFF) guidance with a framework of TFF in units. The framework is based on a Military Demand-Resource model that highlights the dynamic interactions across demands, resources, and outcomes. A joint team of subject-matter experts identified key variables representing unit fitness demands, resources, and outcomes. The resulting framework informs and supports leaders, support agencies, and enterprise efforts to strengthen TFF in units by (1) identifying TFF unit variables aligned with current evidence and operational practices, (2) standardizing communication about TFF in units across the Department of Defense enterprise in a variety of military organizational contexts, (3) improving current resources including evidence-based actions for leaders, (4) identifying and addressing of gaps, and (5) directing future research for enhancing TFF in units. These goals are intended to inform and enhance Service efforts to develop Service-specific TFF models, as well as provide the conceptual foundation for a follow-on article about TFF metrics for units. C1 [Bates, Mark J.; Pinder, Evette D.] Def Ctr Excellence Psychol Hlth & Traumat Brain I, Silver Spring, MD 20910 USA. [Fallesen, Jon J.] Ctr Army Leadership, Fort Leavenworth, KS 66027 USA. [Huey, Wesley S.] US Naval Acad, Dept Leader Dev & Res, Annapolis, MD 21402 USA. [Packard, Gary A., Jr.; Watola, Daniel J.] US Air Force Acad, Dept Behav Sci & Leadership, Colorado Springs, CO 80840 USA. [Ryan, Diane M.] US Mil Acad, Dept Behav Sci & Leadership, West Point, NY 10996 USA. [Burke, C. Shawn] Univ Cent Florida, Inst Simulat & Training, Orlando, FL 32826 USA. [Smith, David G.] US Naval Acad, Leadership Eth & Law Dept, Annapolis, MD 21402 USA. [Yosick, Todd M.] Off Army Surgeon Gen, Def Hlth Headquarters, Falls Church, VA 22042 USA. [Estrada, Armando X.] US Army Res Inst, Aberdeen Proving Ground, MD 21005 USA. [Crepeau, Loring] Def Equal Opportun Management Inst, Patrick Air Force Base, FL 32925 USA. [Bowles, Stephen V.] Natl Def Univ, Ind Coll Armed Forces, Washington, DC 20319 USA. RP Bates, MJ (reprint author), Def Ctr Excellence Psychol Hlth & Traumat Brain I, 1335 East West Highway, Silver Spring, MD 20910 USA. NR 137 TC 0 Z9 0 U1 3 U2 7 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD NOV PY 2013 VL 178 IS 11 BP 1164 EP 1182 DI 10.7205/MILMED-D-12-00519 PG 19 WC Medicine, General & Internal SC General & Internal Medicine GA AN7UE UT WOS:000340805700004 PM 24183762 ER PT J AU Goodin, JL Pizarro-Matos, JM Prasad, BM Seiter, TJ Weaver, CR Muza, SR Beidleman, BA Wood, JC AF Goodin, Jeremy L. Pizarro-Matos, Jose M. Prasad, Balakrishna M. Seiter, Thomas J. Weaver, Courtney R. Muza, Stephen R. Beidleman, Beth A. Wood, Joseph C. TI Evaluating the Molecular Basis for Acute Mountain Sickness: Hypoxia Response Gene Expression Patterns in Warfighters and Murine Populations SO MILITARY MEDICINE LA English DT Article ID BLOOD-BRAIN-BARRIER; ALTITUDE ILLNESS; PROTEIN-4; ASCENT; ANGIOPOIETIN-LIKE-4; ANGIOGENESIS; PERMEABILITY; INHIBITION AB Acute mountain sickness (AMS) is an illness that affects many individuals at altitudes above 2,400 m (8,000 ft) resulting in decreased performance. Models that provide quantitative estimates of AMS risk are expanding, but predictive genetic models for AMS susceptibility are still under investigation. Thirty-four male U.S. Army Soldier volunteers were exposed to baseline, 3,000 m, 3,500 m, or 4,500 m altitude conditions in a hypobaric chamber and evaluated for onset of AMS symptoms. In addition, mice were evaluated at extreme hypoxia conditions equivalent to 7,600 m. Real-time polymerase chain reaction hypoxia response array was used to identify 15 genes that were activated in Soldiers and 46 genes that were activated in mice. We identified angiopoietin-like 4 (ANGPTL4) as a gene that is significantly activated in response to hypoxia (5.8-fold upregulated at 4,500 m in humans). The role of ANGPTL4 in high-altitude response has not been explored. Pretreatment of mice with fenofibrate, an ANGPTL4-activating pharmaceutical, had a considerable effect on overall hypoxia response gene expression and resulted in significantly decreased cerebral edema following exposure to hypoxia. Activation of ANGPTL4 may protect against cerebral edema by inhibiting vascular endothelial growth factor and therefore serve as a potential target for AMS prevention. C1 [Goodin, Jeremy L.; Pizarro-Matos, Jose M.; Prasad, Balakrishna M.; Seiter, Thomas J.; Weaver, Courtney R.; Wood, Joseph C.] Dwight D Eisenhower Army Med Ctr, Dept Clin Invest, Ft Gordon, GA 30905 USA. [Muza, Stephen R.; Beidleman, Beth A.] US Army Res Inst Environm Med, Natick, MA 01760 USA. RP Goodin, JL (reprint author), Dwight D Eisenhower Army Med Ctr, Dept Clin Invest, Bldg 38705,7th St, Ft Gordon, GA 30905 USA. FU Defense Medical Research and Development Program [D61_I_10_J5_178]; U.S. Army FX This project was funded by in part by the Defense Medical Research and Development Program Proposal Number D61_I_10_J5_178 and the U.S. Army. NR 38 TC 2 Z9 4 U1 1 U2 11 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD NOV PY 2013 VL 178 IS 11 BP 1256 EP 1263 DI 10.7205/MILMED-D-13-00185 PG 8 WC Medicine, General & Internal SC General & Internal Medicine GA AN7UE UT WOS:000340805700018 PM 24183776 ER PT J AU Shaffer, SW Teyhen, DS Lorenson, CL Warren, RL Koreerat, CM Straseske, CA Childs, JD AF Shaffer, Scott W. Teyhen, Deydre S. Lorenson, Chelsea L. Warren, Rick L. Koreerat, Christina M. Straseske, Crystal A. Childs, John D. TI Y-Balance Test: A Reliability Study Involving Multiple Raters SO MILITARY MEDICINE LA English DT Article ID CHRONIC ANKLE INSTABILITY; DYNAMIC POSTURAL-CONTROL; LOWER-EXTREMITY BIOMECHANICS; HIGH-SCHOOL BASKETBALL; INJURIES; FATIGUE; PROGRAM; RISK; STABILIZATION; PERFORMANCE AB The Y-balance test (YBT) is one of the few field expedient tests that have shown predictive validity for injury risk in an athletic population. However, analysis of the YBT in a heterogeneous population of active adults (e.g., military, specific occupations) involving multiple raters with limited experience in a mass screening setting is lacking. The primary purpose of this study was to determine interrater test-retest reliability of the YBT in a military setting using multiple raters. Sixty-four service members (53 males, 11 females) actively conducting military training volunteered to participate. Interrater test-retest reliability of the maximal reach had intraclass correlation coefficients (2,1) of 0.80 to 0.85 with a standard error of measurement ranging from 3.1 to 4.2 cm for the 3 reach directions (anterior, posteromedial, and posterolateral). Interrater test-retest reliability of the average reach of 3 trails had an intraclass correlation coefficients (2,3) range of 0.85 to 0.93 with an associated standard error of measurement ranging from 2.0 to 3.5cm. The YBT showed good interrater test-retest reliability with an acceptable level of measurement error among multiple raters screening active duty service members. In addition, 31.3% (n = 20 of 64) of participants exhibited an anterior reach asymmetry of >4cm, suggesting impaired balance symmetry and potentially increased risk for injury. C1 [Shaffer, Scott W.; Lorenson, Chelsea L.; Warren, Rick L.; Koreerat, Christina M.; Straseske, Crystal A.; Childs, John D.] Baylor Univ, US Army, Doctoral Program Phys Therapy, ATTN MCCS HGP, Ft Sam Houston, TX 78234 USA. [Teyhen, Deydre S.] US Army Med Res & Mat Command, Telemed & Adv Technol Res Ctr, ATTN MCMR TT, Ft Detrick, MD 21702 USA. RP Shaffer, SW (reprint author), Baylor Univ, US Army, Doctoral Program Phys Therapy, ATTN MCCS HGP, 3599 Winfield Scott Rd,Suite 1301, Ft Sam Houston, TX 78234 USA. NR 35 TC 15 Z9 15 U1 2 U2 10 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD NOV PY 2013 VL 178 IS 11 BP 1264 EP 1270 DI 10.7205/MILMED-D-13-00222 PG 7 WC Medicine, General & Internal SC General & Internal Medicine GA AN7UE UT WOS:000340805700019 PM 24183777 ER PT J AU Gordon, S Berenberg, JL Ferguson, T Mitchell, JD AF Gordon, Sarah Berenberg, Jeffrey L. Ferguson, Tomas Mitchell, Jacqui D. TI Hepatitis B surveillance in adult chemotherapy patients SO JOURNAL OF CLINICAL ONCOLOGY LA English DT Meeting Abstract CT ASCO's Quality Care Symposium CY NOV 01-02, 2013 CL San Diego, CA SP ASCO C1 [Gordon, Sarah; Berenberg, Jeffrey L.; Ferguson, Tomas; Mitchell, Jacqui D.] Tripler Army Med Ctr, Honolulu, HI 96859 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC CLINICAL ONCOLOGY PI ALEXANDRIA PA 2318 MILL ROAD, STE 800, ALEXANDRIA, VA 22314 USA SN 0732-183X EI 1527-7755 J9 J CLIN ONCOL JI J. Clin. Oncol. PD NOV 1 PY 2013 VL 31 IS 31 SU S MA 76 PG 1 WC Oncology SC Oncology GA AG6YR UT WOS:000335565500076 ER PT J AU Kryskow, MA Beidleman, BA Fulco, CS Muza, SR AF Kryskow, Mark A. Beidleman, Beth A. Fulco, Charles S. Muza, Stephen R. TI Performance During Simple and Complex Military Psychomotor Tasks at Various Altitudes SO AVIATION SPACE AND ENVIRONMENTAL MEDICINE LA English DT Article DE hypobaric hypoxia; cognitive performance; hypoxia; acute mountain sickness ID ACUTE MOUNTAIN-SICKNESS; MOOD; MARKSMANSHIP; PREVALENCE; SYMPTOMS; HYPOXIA; OXYGEN; ALPS AB The purposes were to determine the following: 1) the threshold between 2500-4300 m at which simple and complex military task performance is degraded; 2) whether the degree of degradation, if any, is related to changes in altitude illness, fatigue, or sleepiness at a given altitude; and 3) whether the level of hypoxemia, independent of altitude, affects simple and complex military task performance. Methods: There were 57 lowlanders (mean +/- SD; 22 +/- 3 yr; 79 +/- 12 kg) who were exposed to either 2500 m (N = 17), 3000 m (N = 12), 3500 m (N = 11), or 4300 m (N = 17). Disassembly and reassembly of a weapon (DsAs, simple), rifle marksmanship (RM, complex), acute mountain sickness (AMS), fatigue, sleepiness, and arterial oxygen saturation (SaO2) were measured at sea level (SL), and after 8 h (HA8) and 30 h (HA30) of exposure to each altitude. Results: Ds As did not change from SL to HA8 or HA30 at any altitude. RM speed (target/min) decreased from SL (20 +/- 1.5) to HA8 (17 +/- 1.5) and HA30 (17 +/- 3) only at 4300 m. AMS, fatigue, and sleepiness were increased and SaO2 was decreased at 2500 m and above. Increased sleepiness was the only variable associated with decreased RM speed at 4300 m (r = -0.67; P = 0.004). Greater hypoxemia, independent of altitude, was associated with greater decrements in RM speed (r = 0.27; P = 0.04). Conclusions: Simple psychomotor performance was not affected by exposures between 2500-4300 m; however, complex psychomotor performance (i.e., RM speed) was degraded at 4300 m most likely due to increased sleepiness. Greater levels of hypoxemia were associated with greater decrements in RM speed. C1 [Kryskow, Mark A.; Beidleman, Beth A.; Fulco, Charles S.; Muza, Stephen R.] US Army, Environm Med Res Inst, Thermal & Mt Med Div, Natick, MA 01760 USA. RP Beidleman, BA (reprint author), US Army, Environm Med Res Inst, Thermal & Mt Med Div, Natick, MA 01760 USA. EM beth.a.beidleman.civ@mail.mil NR 26 TC 4 Z9 5 U1 2 U2 9 PU AEROSPACE MEDICAL ASSOC PI ALEXANDRIA PA 320 S HENRY ST, ALEXANDRIA, VA 22314-3579 USA SN 0095-6562 EI 1943-4448 J9 AVIAT SPACE ENVIR MD JI Aviat. Space Environ. Med. PD NOV PY 2013 VL 84 IS 11 BP 1147 EP 1152 DI 10.3357/ASEM.3245.2013 PG 6 WC Public, Environmental & Occupational Health; Medicine, General & Internal; Sport Sciences SC Public, Environmental & Occupational Health; General & Internal Medicine; Sport Sciences GA AD1LY UT WOS:000332996700004 PM 24279227 ER PT J AU Malin, EW Galin, CM Lairet, KF Huzar, TF Williams, JF Renz, EM Wolf, SE Cancio, LC AF Malin, Edward W. Galin, Chaya M. Lairet, Kimberley F. Huzar, Todd F. Williams, James F. Renz, Evan M. Wolf, Steven E. Cancio, Leopoldo C. TI Silver-Coated Nylon Dressing Plus Active DC Microcurrent for Healing of Autogenous Skin Donor Sites SO ANNALS OF PLASTIC SURGERY LA English DT Article DE burns; electric stimulation therapy; silver; bandages; skin transplantation; wound healing ID WEAK DIRECT-CURRENT; NANOCRYSTALLINE SILVER; ELECTROMAGNETIC-FIELDS; CELL BEHAVIOR; WOUNDS; MODEL; BURNS AB Introduction: Burn wounds are a significant cause of morbidity and mortality, and improved outcomes are demonstrated with early closure of both primary burn wounds and skin donor sites. Thus, technology that decreases the healing time of burns and donor sites would be potentially lifesaving. We present the results of a single-center, prospective, double-blinded, randomized controlled trial to evaluate the efficacy of silver-coated dressing with active microcurrent in comparison to silver-coated dressing with sham microcurrent on wound-closure time for autogenous skin donor sites. Methods: Four hundred five patients were screened for treatment of their donor sites using a silver-coated nylon dressing with either sham or active microcurrent stimulation. Thirty patients were enrolled in the study and then randomized. Of these, 5 patients were removed from analysis due to protocol deviations. Differences in time-to-closure were analyzed using Kaplan-Meier analysis and the proportional hazard regression model. Subjective verbal pain rating scores (0-10; 0, no pain; 10, worst pain) were also recorded. All devices were blinded and programmed at an outside facility, so that every patient had either an active or sham device. The study was unblinded only after the final patient's donor site had healed. All patients achieved donor-site healing before postoperative day 20. The 14 patients in the active microcurrent group [mean, 10.8 (2.9) days; range, 7-15 days] experienced no difference in time to wound healing as compared to the remaining patients in the sham microcurrent group [mean, 11.1 (2.0) days; range, 8-14 days; P = 0.75]. There were no differences in pain from one group compared to the other. None of the donor sites exhibited clinical signs of infection. Conclusions: In a sample size of 25 burn patients, the addition of direct microcurrent to silver-nylon dressings did not decrease time to wound closure of skin donor sites, and it did not show a difference in reported pain levels. C1 [Malin, Edward W.; Galin, Chaya M.; Lairet, Kimberley F.; Huzar, Todd F.; Williams, James F.; Renz, Evan M.; Wolf, Steven E.; Cancio, Leopoldo C.] US Army Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Cancio, LC (reprint author), US Army Inst Surg Res, 3698 Chambers Pass, Ft Sam Houston, TX 78234 USA. EM divego99@gmail.com OI Wolf, Steven/0000-0003-2972-3440 FU Clinical Trials Task Area, Combat Casualty Care Research Program, US Army Medical Research and Material Command, Fort Detrick, MD FX Funded by the Clinical Trials Task Area, Combat Casualty Care Research Program, US Army Medical Research and Material Command, Fort Detrick, MD. NR 26 TC 4 Z9 4 U1 2 U2 7 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0148-7043 EI 1536-3708 J9 ANN PLAS SURG JI Ann. Plast. Surg. PD NOV PY 2013 VL 71 IS 5 BP 481 EP 484 DI 10.1097/SAP.0b013e31829d2311 PG 4 WC Surgery SC Surgery GA 300IJ UT WOS:000330457300011 PM 23903090 ER PT J AU Trope, RL AF Trope, Roland L. TI Bearings from the Southern Cross: Cybersecurity Decisions 2012-2013 SO BUSINESS LAWYER LA English DT Article C1 [Trope, Roland L.] Trope & Schramm LLP, New York City Off, New York, NY 10017 USA. [Trope, Roland L.] US Mil Acad, Dept Law, West Point, NY USA. RP Trope, RL (reprint author), Trope & Schramm LLP, New York City Off, New York, NY 10017 USA. EM rltrope@tropelaw.com NR 6 TC 1 Z9 1 U1 0 U2 1 PU AMER BAR ASSOC, ADMINISTRATIVE LAW & REGULATORY PRACTICE SECTION PI CHICAGO PA 321 N CLARK ST, CHICAGO, IL 60610 USA SN 0007-6899 EI 2164-1838 J9 BUS LAWYER JI Bus. Lawyer PD NOV PY 2013 VL 69 IS 1 BP 189 EP 197 PG 9 WC Law SC Government & Law GA 297KG UT WOS:000330253700009 ER PT J AU Benson, BC Smith, C Laczek, JT AF Benson, Brian C. Smith, Carin Laczek, Jeffrey T. TI Angiotensin Converting Enzyme Inhibitor-induced Gastrointestinal Angioedema A Case Series and Literature Review SO JOURNAL OF CLINICAL GASTROENTEROLOGY LA English DT Review DE angiotensin converting enzyme inhibitor; gastrointestinal angioedema; bowel wall thickening; angioedema; ACE inhibitor-induced angioedema ID SMALL-BOWEL ANGIOEDEMA; ISOLATED VISCERAL ANGIOEDEMA; ABDOMINAL-PAIN; HEREDITARY ANGIOEDEMA; SMALL-INTESTINE; EDEMA; DIAGNOSIS; SECONDARY; THERAPY; MUCOSAL AB Goals: The objective of this study was to better understand the presenting signs and symptoms of angiotensin converting enzyme (ACE) inhibitor-induced gastrointestinal angioedema, review the medical literature related to this condition, and bring this diagnosis to the attention of clinicians. Background: Angioedema occurs in 0.1% to 0.7% of patients treated with ACE inhibitors and ACE inhibitors account for 20% to 30% of all angioedema cases presenting to emergency departments. However, only recently have ACE inhibitors been recognized as a cause of angioedema of the gastrointestinal tract. Patients with this disease present with one or more episodes of abdominal pain associated with nausea, vomiting, and/or diarrhea. Study: We present four cases of ACE inhibitor-induced gastrointestinal angioedema seen at a single institution and review the literature of other case reports. Results: Review of the medical literature identified 27 case reports of ACE inhibitor-induced angioedema of the gastrointestinal tract. Multiple ACE inhibitors were implicated in these case reports suggesting that this disease is a class effect of ACE inhibitors. In cases where the race of the patient was stated, 50% were identified as being African American. Ascities was described as a radiographic finding in 16 of 27 cases. There were no reported cases of paracentesis or ascitic fluid analysis described in any of the identified case reports. Conclusions: This series highlights ascites as a key feature that distinguishes ACE inhibitor-induced gastrointestinal angioedema from infectious enteritis. This series also confirms the increased incidence of this condition among African American women, an unpredictable interval between medication initiation and the development of symptoms, and the heightened probability of symptom recurrence if ACE inhibitors are not discontinued. ACE inhibitor-induced gastrointestinal angioedema is a rare cause of acute abdominal complaints, but is likely underdiagnosed and should be considered in the differential diagnosis of all individuals taking ACE inhibitors with such symptoms. Early recognition of ACE inhibitor-induced gastrointestinal angioedema may avoid recurrent episodes or costly, invasive evaluations. C1 [Benson, Brian C.; Smith, Carin] Tripler Army Med Ctr, Dept Internal Med, Honolulu, HI 96859 USA. [Laczek, Jeffrey T.] Tripler Army Med Ctr, Gastroenterol Serv, Honolulu, HI 96859 USA. RP Laczek, JT (reprint author), Tripler Army Med Ctr, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM jeffrey.laczek@us.army.mil NR 40 TC 8 Z9 10 U1 1 U2 4 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0192-0790 EI 1539-2031 J9 J CLIN GASTROENTEROL JI J. Clin. Gastroenterol. PD NOV-DEC PY 2013 VL 47 IS 10 BP 844 EP 849 PG 6 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 298TZ UT WOS:000330348700006 PM 23751839 ER PT J AU Tilak, AS Ojewole, S Williford, CW Fox, GA Sobecki, TM Larson, SL AF Tilak, A. S. Ojewole, S. Williford, C. W. Fox, G. A. Sobecki, T. M. Larson, S. L. TI Formation of Manganese Oxide Coatings onto Sand for Adsorption of Trace Metals from Groundwater SO JOURNAL OF ENVIRONMENTAL QUALITY LA English DT Article ID COATED FILTER MEDIA; SOLUBLE MANGANESE; REMEDIATION TECHNOLOGIES; WATER-TREATMENT; REMOVAL; FILTRATION; SURFACES; BARRIERS; IRON; LEAD AB Manganese oxide (MnOx(s)) occurs naturally in soil and has a high affinity for trace metals adsorption. In this work, we quantified the factors (pH; flow rate; use of oxidants such as bleach, H2O2, and O-3; initial Mn(II) concentrations; and two types of geologic media) affecting MnOx(s) coatings onto Ottawa and aquifer sand using batch and column experiments. The batch experiments consisted of manual and automated titration, and the column experiments mimicked natural MnOx(s) adsorption and oxidation cycles as a strategy for in situ adsorption. A Pb solution of 50 mg L-1 was passed through MnOx(s)-coated sand at a flow rate of 4 mL min(-1) to determine its adsorption capacity. Batch experimental results showed that MnOx(s) coatings increased from pH 6 to 8, with maximum MnOx(s) coating occurring at pH 8. Regarding MnOx(s) coatings, bleach and O-3 were highly effective compared with H2O2. The Ottawa sand had approximately twice the MnOx(s) coating of aquifer sand. The sequential increase in initial Mn(II) concentrations on both sands resulted in incremental buildup of MnOx(s). The automated procedure enhanced MnOx(s) coatings by 3.5 times compared with manual batch experiments. Column results showed that MnOx(s) coatings were highly dependent on initial Mn(II) and oxidant concentrations, pH, flow rate, number of cycles (h), and the type of geologic media used. Manganese oxide coating exceeded 1700 mg kg(-1) for Ottawa sand and 130 mg kg(-1) for aquifer sand. The Pb adsorption exceeded 2200 mg kg(-1) for the Ottawa sand and 300 mg kg(-1) for the aquifer sand. C1 [Tilak, A. S.] Univ Birmingham, Dep Geog & Earth Sci, Birmingham, W Midlands, England. [Ojewole, S.] Invensys Operat Management, Houston, TX 77041 USA. [Williford, C. W.] Univ Mississippi, Oxford, MS 38677 USA. [Fox, G. A.] Oklahoma State Univ, Dep Biosyst & Agr Engn, Stillwater, OK 74078 USA. [Sobecki, T. M.] USACE Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. [Larson, S. L.] US Army Corp Engineers, Engn Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Tilak, AS (reprint author), Univ Birmingham, Dep Geog & Earth Sci, Birmingham, W Midlands, England. EM ameytilak@gmail.com; drwill@olemiss.edu FU U.S. Army Corp of Engineers, Engineering Research and Development Center (ERDC) at the Water Ways Experiment Station (WES) Vicksburg, MS FX This work was supported by the U.S. Army Corp of Engineers, Engineering Research and Development Center (ERDC) at the Water Ways Experiment Station (WES) Vicksburg, MS. The authors thank Dr. June Mirecki and Dr. Tony Bednar at WES for access to the automated titrator and analytical support; Mr. David Burkhart of the Mettler-Toledo, maker of the automated titration system, for valuable assistance through instruction, equipment set up, and customization of the LabX software algorithm; and Dr. Ashraf Soltan of the Military Technical College of Cairo, Egypt for reviewing the manuscript. NR 44 TC 0 Z9 0 U1 4 U2 15 PU AMER SOC AGRONOMY PI MADISON PA 677 S SEGOE RD, MADISON, WI 53711 USA SN 0047-2425 EI 1537-2537 J9 J ENVIRON QUAL JI J. Environ. Qual. PD NOV-DEC PY 2013 VL 42 IS 6 BP 1743 EP 1751 DI 10.2134/jeq2013.04.0142 PG 9 WC Environmental Sciences SC Environmental Sciences & Ecology GA 300KJ UT WOS:000330462500014 PM 25602414 ER PT J AU Torres, LN Sondeen, JL Ji, L Dubick, MA Torres, I AF Torres, Luciana N. Sondeen, Jill L. Ji, Lisa Dubick, Michael A. Torres Filho, Ivo TI Evaluation of resuscitation fluids on endothelial glycocalyx, venular blood flow, and coagulation function after hemorrhagic shock in rats SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY LA English DT Article DE Microcirculation; skeletal muscle; blood flow; coagulation; resuscitation ID NATURAL COLLOID RESUSCITATION; PROTEIN-C; DILUTIONAL COAGULOPATHY; INCREASING HEMORRHAGE; INTRAVITAL MICROSCOPY; MASSIVE TRANSFUSION; CELL GLYCOCALYX; CLOT FORMATION; IN-VIVO; PLASMA AB BACKGROUND: Endothelial glycocalyx (EG) plays an essential role in endothelium integrity and may be compromised by hemorrhagic shock. The effects of currently available resuscitation fluids such as Hextend (HEX) or lactated Ringer's solution (LR) on vascular function and coagulation are not well understood. The aim of the present study was to compare the effects of fresh frozen plasma (FFP) with HEX or LR in their ability to repair EG structure, promote volume expansion, increase blood flow, and prevent coagulopathy. METHODS: A total of 121 microvessels from cremaster muscle were studied in 32 anesthetized instrumented rats. After baseline systemic and microvascular measurements, 40% hemorrhage followed by resuscitation was performed, and measurements were repeated. Coagulation was evaluated using ROTEM to assay clot formation time, clotting time, firmness, strength, and lysis. Velocity and "platelet component" of strength were calculated. Fluorescein isothiocyanate or Texas Red bound to Dextrans was injected to estimate EG thickness in vivo. RESULTS: Respiratory rate, blood pH, base excess, and lactate returned to near-baseline levels in all treatments. Hemodilution caused by LR and HEX decreased firmness, prolonged clotting time, and lowered platelet counts. EG thickness in HEX-and LR-treated rats was 50% lower, and plasma syndecan 1 was 50% higher than sham and FFP groups. Blood flow and shear rate were restored in the HEX group. Resuscitation with FFP improved coagulation and blood flow. CONCLUSION: Our findings support the concept of cardiovascular and microvascular stabilization by infused FFP, in which the increase in microvascular perfusion associated with restored EG is essential for an optimal resuscitation strategy. (J Trauma Acute Care Surg. 2013;75:759-766. Copyright (C) 2013 by Lippincott Williams & Wilkins) C1 [Torres, Luciana N.; Sondeen, Jill L.; Ji, Lisa; Dubick, Michael A.; Torres Filho, Ivo] US Army Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Torres, LN (reprint author), US Army Inst Surg Res, 3698 Chambers Pass,BHT 2,Room 281-3, Ft Sam Houston, TX 78234 USA. EM luciana.n.torres.ctr@mail.mil FU US Army Combat Casualty Care Research Program; US Army Medical Research and Materiel Command FX This study was supported in part by the US Army Combat Casualty Care Research Program and by the US Army Medical Research and Materiel Command. L.N.T. held a National Research Council Senior Associateship at the US Army Institute of Surgical Research, and I.T.F. was employed by Universidade do Estado do Rio de Janeiro and Premier Consulting & Management Services, Inc. NR 41 TC 36 Z9 36 U1 4 U2 10 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 2163-0755 EI 2163-0763 J9 J TRAUMA ACUTE CARE JI J. Trauma Acute Care Surg. PD NOV PY 2013 VL 75 IS 5 BP 759 EP 766 DI 10.1097/TA.0b013e3182a92514 PG 8 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 300IP UT WOS:000330457900002 PM 24158192 ER PT J AU Kheirabadi, BS Sandeen, JL Dubick, MA AF Kheirabadi, Bijan Shams Sandeen, Jill L. Dubick, Michael A. TI Re: The significance of splenectomy in experimental swine models of hemorrhagic shock Reply SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY LA English DT Letter ID BLOOD-VOLUME; SPLEEN; PIGS; DOGS C1 [Kheirabadi, Bijan Shams; Sandeen, Jill L.; Dubick, Michael A.] US Army Inst Surg Res, JBSA Ft Sam Houston, San Antonio, TX USA. RP Kheirabadi, BS (reprint author), US Army Inst Surg Res, JBSA Ft Sam Houston, San Antonio, TX USA. NR 5 TC 1 Z9 1 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 2163-0755 EI 2163-0763 J9 J TRAUMA ACUTE CARE JI J. Trauma Acute Care Surg. PD NOV PY 2013 VL 75 IS 5 BP 920 EP 921 PG 3 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 300IP UT WOS:000330457900029 PM 24158219 ER PT J AU Tenan, MS Peng, YL Hackney, AC Griffin, L AF Tenan, Matthew S. Peng, Yi-Ling Hackney, Anthony C. Griffin, Lisa TI Menstrual Cycle Mediates Vastus Medialis and Vastus Medialis Oblique Muscle Activity SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Article DE ESTRADIOL; KNEE INJURY; MOTOR UNIT; PATELLOFEMORAL SYNDROME; PROGESTERONE; QUADRICEPS ID PATELLOFEMORAL PAIN SYNDROME; HUMAN MOTOR UNITS; GENDER-DIFFERENCES; RECRUITMENT; BEHAVIOR; RECEPTOR; GABA; EXCITABILITY; INCREASES; OVULATION AB Purpose: Sports medicine professionals commonly describe two functionally different units of the vastus medialis (VM), the VM, and the vastus medialis oblique (VMO), but the anatomical support is equivocal. The functional difference of the VMO is principle to rehabilitation programs designed to alleviate anterior knee pain, a pathology that is known to have a greater occurrence in women. The purpose of this study was to determine whether the motor units of the VM and VMO are differentially recruited and if this recruitment pattern has an effect of sex or menstrual cycle phase. Methods: Single motor unit recordings from the VM and VMO were obtained for men and women during an isometric ramp knee extension. Eleven men were tested once. Seven women were tested during five different phases of the menstrual cycle, determined by basal body temperature mapping. The recruitment threshold and the initial firing rate at recruitment were determined from 510 motor unit recordings. Results: The initial firing rate was lower in the VMO than that in the VM in women (P < 0.001) but not in men. There was no difference in recruitment thresholds for the VM and VMO in either sex or across the menstrual cycle. There was a main effect of menstrual phase on initial firing rate, showing increases from the early follicular to late luteal phase (P = 0.003). The initial firing rate in the VMO was lower than that in the VM during ovulatory (P = 0.009) and midluteal (P = 0.009) phases. Conclusion: The relative control of the VM and VMO changes across the menstrual cycle. This could influence patellar pathologies that have a higher incidence in women. C1 [Tenan, Matthew S.; Peng, Yi-Ling; Griffin, Lisa] Univ Texas Austin, Dept Kinesiol, Austin, TX 78712 USA. [Tenan, Matthew S.] US Army Res Lab, Human Res & Engn Directorate, Aberdeen Proving Ground, MD USA. [Hackney, Anthony C.] Univ N Carolina, Dept Exercise & Sport Sci, Chapel Hill, NC USA. RP Griffin, L (reprint author), Univ Texas Austin, Dept Kinesiol & Hlth Educ, Bellmont 222,1 Univ Stn,D3700, Austin, TX 78712 USA. EM l.griffin@austin.utexas.edu FU Department of Defense SMART Scholarship Program FX Matthew S. Tenan was supported in full by the Department of Defense SMART Scholarship Program. NR 35 TC 8 Z9 8 U1 1 U2 5 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 EI 1530-0315 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD NOV PY 2013 VL 45 IS 11 BP 2151 EP 2157 DI 10.1249/MSS.0b013e318299a69d PG 7 WC Sport Sciences SC Sport Sciences GA 300LJ UT WOS:000330465100017 PM 23657168 ER PT J AU Ogg, M Jonsson, CB Camp, JV Hooper, JW AF Ogg, Monica Jonsson, Colleen B. Camp, Jeremy V. Hooper, Jay W. TI Ribavirin Protects Syrian Hamsters against Lethal Hantavirus Pulmonary Syndrome - After Intranasal Exposure to Andes Virus SO VIRUSES-BASEL LA English DT Article DE hantaviruses; ribavirin; hamster; prophylactic; post-exposure antiviral ID TO-PERSON TRANSMISSION; SIN-NOMBRE-VIRUS; HEMORRHAGIC-FEVER; INTRAVENOUS RIBAVIRIN; RENAL SYNDROME; HANTAAN VIRUS; IN-VITRO; ANTIVIRAL ACTIVITY; CARDIOPULMONARY SYNDROME; SOUTHERN ARGENTINA AB Andes virus, ANDV, harbored by wild rodents, causes the highly lethal hantavirus pulmonary syndrome (HPS) upon transmission to humans resulting in death in 30% to 50% of the cases. As there is no treatment for this disease, we systematically tested the efficacy of ribavirin in vitro and in an animal model. In vitro assays confirmed antiviral activity and determined that the most effective doses were 40 mu g/mL and above. We tested three different concentrations of ribavirin for their capability to prevent HPS in the ANDV hamster model following an intranasal challenge. While the highest level of ribavirin (200 mg/kg) was toxic to the hamster, both the middle (100 mg/kg) and the lowest concentration (50 mg/kg) prevented HPS in hamsters without toxicity. Specifically, 8 of 8 hamsters survived intranasal challenge for both of those groups whereas 7 of 8 PBS control-treated animals developed lethal HPS. Further, we report that administration of ribavirin at 50 mg/kg/day starting on days 6, 8, 10, or 12 post-infection resulted in significant protection against HPS in all groups. Administration of ribavirin at 14 days post-infection also provided a significant level of protection against lethal HPS. These data provide in vivo evidence supporting the potential use of ribavirin as a post-exposure treatment to prevent HPS after exposure by the respiratory route. C1 [Ogg, Monica; Hooper, Jay W.] US Army Med Res Inst Infect Dis, Mol Virol Branch, Ft Detrick, MD 21772 USA. [Jonsson, Colleen B.; Camp, Jeremy V.] Ctr Predict Med Infect Dis & Biodef, Dept Microbiol & Immunol, Louisville, KY 40202 USA. RP Jonsson, CB (reprint author), Ctr Predict Med Infect Dis & Biodef, Dept Microbiol & Immunol, Louisville, KY 40202 USA. EM Monica.m.ogg.ctr@mail.mil; cbjons01@louisville.edu; jvcamp01@exchange.louisville.edu; jay.w.hooper@us.army.mil OI Hooper, Jay/0000-0002-4475-0415 FU NIH [R21 AI064499-01]; U.S. Army Medical Research and Material Command, Military Infectious Disease Research Program FX This work was supported by NIH Grant R21 AI064499-01 to CBJ and JWH and by the U.S. Army Medical Research and Material Command, Military Infectious Disease Research Program, Program Area T. Opinions, interpretations, conclusions, and recommendations are ours and are not necessarily endorsed by the U.S. Army or the Department of Defense. NR 50 TC 8 Z9 8 U1 0 U2 6 PU MDPI AG PI BASEL PA POSTFACH, CH-4005 BASEL, SWITZERLAND SN 1999-4915 J9 VIRUSES-BASEL JI Viruses-Basel PD NOV PY 2013 VL 5 IS 11 BP 2704 EP 2720 DI 10.3390/v5112704 PG 17 WC Virology SC Virology GA 301HK UT WOS:000330523200006 PM 24217424 ER PT J AU Asteris, PG Cotsovos, DM Chrysostomou, CZ Mohebkhah, A Al-Chaar, GK AF Asteris, P. G. Cotsovos, D. M. Chrysostomou, C. Z. Mohebkhah, A. Al-Chaar, G. K. TI Mathematical micromodeling of infilled frames: State of the art SO ENGINEERING STRUCTURES LA English DT Article DE Discrete element method; Finite elements; Infilled frames; Interface elements; Masonry; Nonlinear analysis ID REINFORCED-CONCRETE FRAMES; FINITE-ELEMENT-ANALYSIS; HIGH LOADING RATES; RC FRAMES; MASONRY INFILL; SEISMIC RESPONSE; STEEL FRAMES; BRICK MASONRY; LATERAL STIFFNESS; DYNAMIC-RESPONSE AB The in-plane contribution of infill walls on the structural response of infilled frame structures is an important problem and many research initiatives, via experimental and numerical methods, have been conducted in order to investigate it thoroughly. As a result, the need to consider these research findings on the structural performance has been acknowledged in the latest generation of structural design codes. However, due to the uncertainties concerning the behavior of masonry at the material and structural level, these elements are usually ignored during practical structural analysis and design. They are overtly considered only when there is suspicion that their influence is detrimental to the overall structural response or to the behavior of individual load bearing elements or when it is necessary to justify an improvement in the overall load-carrying capacity or structural performance in general. In this paper, a thorough overview of the different micromodels proposed for the analysis of infilled frames is presented, and the advantages and disadvantages of each micromodel are pointed out (this paper follows our recent review paper on the state-of-the-art of the mathematical macromodeling of infilled frames, thus completing the overview of both macro- and micro- models in the field). Practical recommendations for the implementation of the different models are also presented. (C) 2013 Elsevier Ltd. All rights reserved. C1 [Asteris, P. G.] Sch Pedag & Technol Educ, Dept Civil Engn, Computat Mech Lab, Athens GR-14121, Greece. [Cotsovos, D. M.] Heriot Watt Univ, Sch Built Environm, Inst Infrastruct & Environm, Edinburgh EH14 4AS, Midlothian, Scotland. [Chrysostomou, C. Z.] Cyprus Univ Technol, Dept Civil Engn & Geomat, CY-3603 Limassol, Cyprus. [Mohebkhah, A.] Malayer Univ, Dept Struct Engn, Malayer, Iran. [Al-Chaar, G. K.] Construct Engn Res Labs, Res & Dev Ctr ERDC, Champaign, IL USA. RP Asteris, PG (reprint author), Sch Pedag & Technol Educ, Dept Civil Engn, Computat Mech Lab, Athens GR-14121, Greece. EM pasteris@otenet.gr; D.Cotsovos@hw.ac.uk; c.chrysostomou@cut.ac.cy; amoheb2001@yahoo.com; Ghassan.k.al-chaar@usace.army.mil RI Chrysostomou, Christis/C-4923-2015; OI Chrysostomou, Christis/0000-0002-7141-7423; Cotsovos, Demitrios/0000-0002-7258-5031 NR 190 TC 27 Z9 27 U1 4 U2 25 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0141-0296 EI 1873-7323 J9 ENG STRUCT JI Eng. Struct. PD NOV PY 2013 VL 56 BP 1905 EP 1921 DI 10.1016/j.engstruct.2013.08.010 PG 17 WC Engineering, Civil SC Engineering GA 293GO UT WOS:000329959600158 ER PT J AU Nestor, A Vettel, JM Tarr, MJ AF Nestor, Adrian Vettel, Jean M. Tarr, Michael J. TI Internal Representations for Face Detection: An Application of Noise-Based Image Classification to BOLD Responses SO HUMAN BRAIN MAPPING LA English DT Article DE face recognition; reverse correlation; fMRI ID HUMAN VISUAL-CORTEX; HUMAN BRAIN ACTIVITY; REAL-TIME FMRI; SPATIAL-FREQUENCY; NEURAL REPRESENTATION; REVERSE-CORRELATION; SELECTIVE REGIONS; TEMPORAL CORTEX; SEEING FACES; PERCEPTION AB What basic visual structures underlie human face detection and how can we extract such structures directly from the amplitude of neural responses elicited by face processing? Here, we address these issues by investigating an extension of noise-based image classification to BOLD responses recorded in high-level visual areas. First, we assess the applicability of this classification method to such data and, second, we explore its results in connection with the neural processing of faces. To this end, we construct luminance templates from white noise fields based on the response of face-selective areas in the human ventral cortex. Using behaviorally and neurally-derived classification images, our results reveal a family of simple but robust image structures subserving face representation and detection. Thus, we confirm the role played by classical face selective regions in face detection and we help clarify the representational basis of this perceptual function. From a theory standpoint, our findings support the idea of simple but highly diagnostic neurally-coded features for face detection. At the same time, from a methodological perspective, our work demonstrates the ability of noise-based image classification in conjunction with fMRI to help uncover the structure of high-level perceptual representations. Hum Brain Mapp 34:3101-3115, 2013. (c) 2012 Wiley Periodicals, Inc. C1 [Nestor, Adrian; Tarr, Michael J.] Carnegie Mellon Univ, Ctr Neural Basis Cognit, Pittsburgh, PA 15213 USA. [Nestor, Adrian; Tarr, Michael J.] Carnegie Mellon Univ, Dept Psychol, Pittsburgh, PA 15213 USA. [Vettel, Jean M.] US Army Res Lab, Aberdeen Proving Ground, MD USA. RP Nestor, A (reprint author), Carnegie Mellon Univ, Ctr Neural Basis Cognit, 4400 Fifth Ave, Pittsburgh, PA 15213 USA. EM anestor@andrew.cmu.edu FU NIH EUREKA award [1R01MH084195-01]; James S. McDonnell Foundation; NSF Science of Learning Center [SBE-0542013] FX Contract grant sponsor: NIH EUREKA award; Contract grant number: 1R01MH084195-01; Contract grant sponsor: James S. McDonnell Foundation (to the Perceptual Expertise Network (PEN)) and NSF Science of Learning Center; Contract grant number: SBE-0542013 (to the Temporal Dynamics of Learning Center (TDLC)). NR 89 TC 5 Z9 5 U1 1 U2 7 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1065-9471 EI 1097-0193 J9 HUM BRAIN MAPP JI Hum. Brain Mapp. PD NOV PY 2013 VL 34 IS 11 BP 3101 EP 3115 DI 10.1002/hbm.22128 PG 15 WC Neurosciences; Neuroimaging; Radiology, Nuclear Medicine & Medical Imaging SC Neurosciences & Neurology; Radiology, Nuclear Medicine & Medical Imaging GA 295FG UT WOS:000330101400029 PM 22711230 ER PT J AU Guskiewicz, KM Goldman, SB AF Guskiewicz, Kevin M. Goldman, Sarah B. TI A Changing Landscape: Traumatic Brain Injury in Military Combat and Civilian Athletics SO FASEB JOURNAL LA English DT Editorial Material ID ENCEPHALOPATHY; CONCUSSION; STATEMENT; SPORT C1 [Guskiewicz, Kevin M.] Univ N Carolina, Matthew Gfeller Sport Related Traumat Brain Injur, Chapel Hill, NC USA. [Goldman, Sarah B.] US Army, Off Surgeon Gen, Rehabil & Reintegrat Div, Falls Church, VA 22042 USA. RP Goldman, SB (reprint author), US Army, Off Surgeon Gen, Rehabil & Reintegrat Div, 7700 Arlington Blvd,3SW128C, Falls Church, VA 22042 USA. EM sarah.b.goldman.mil@mail.mil OI Guskiewicz, Kevin/0000-0002-8682-2130 NR 14 TC 0 Z9 0 U1 1 U2 3 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 EI 1530-6860 J9 FASEB J JI Faseb J. PD NOV PY 2013 VL 27 IS 11 BP 4327 EP 4329 DI 10.1096/fj.13-1101ufm PG 3 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 292YB UT WOS:000329937500001 PM 24179113 ER PT J AU Memisevic, V Zavaljevski, N Pieper, R Rajagopala, SV Kwon, K Townsend, K Yu, CG Yu, XP DeShazer, D Reifman, J Wallqvist, A AF Memisevic, Vesna Zavaljevski, Nela Pieper, Rembert Rajagopala, Seesandra V. Kwon, Keehwan Townsend, Katherine Yu, Chenggang Yu, Xueping DeShazer, David Reifman, Jaques Wallqvist, Anders TI Novel Burkholderia mallei Virulence Factors Linked to Specific Host- Pathogen Protein Interactions SO MOLECULAR & CELLULAR PROTEOMICS LA English DT Article ID GRAM-NEGATIVE BACTERIA; ACTIN-BASED MOTILITY; INFLUENZA-VIRUS REPLICATION; MICROARRAY ANALYSIS; BIOTECHNOLOGY-INFORMATION; BIOINFORMATICS RESOURCE; DATABASE RESOURCES; SECRETION SYSTEMS; IMMUNE-RESPONSE; YERSINIA-PESTIS AB Burkholderia mallei is an infectious intracellular pathogen whose virulence and resistance to antibiotics makes it a potential bioterrorism agent. Given its genetic origin as a commensal soil organism, it is equipped with an extensive and varied set of adapted mechanisms to cope with and modulate host-cell environments. One essential virulence mechanism constitutes the specialized secretion systems that are designed to penetrate host-cell membranes and insert pathogen proteins directly into the host cell's cytosol. However, the secretion systems' proteins and, in particular, their host targets are largely uncharacterized. Here, we used a combined in silico, in vitro, and in vivo approach to identify B. mallei proteins required for pathogenicity. We used bioinformatics tools, including orthology detection and ab initio predictions of secretion system proteins, as well as published experimental Burkholderia data to initially select a small number of proteins as putative virulence factors. We then used yeast two-hybrid assays against normalized whole human and whole murine proteome libraries to detect and identify interactions among each of these bacterial proteins and host proteins. Analysis of such interactions provided both verification of known virulence factors and identification of three new putative virulence proteins. We successfully created insertion mutants for each of these three proteins using the virulent B. mallei ATCC 23344 strain. We exposed BALB/c mice to mutant strains and the wild-type strain in an aerosol challenge model using lethal B. mallei doses. In each set of experiments, mice exposed to mutant strains survived for the 21-day duration of the experiment, whereas mice exposed to the wild-type strain rapidly died. Given their in vivo role in pathogenicity, and based on the yeast two-hybrid interaction data, these results point to the importance of these pathogen proteins in modulating host ubiquitination pathways, phagosomal escape, and actin-cytoskeleton rearrangement processes. Molecular & Cellular Proteomics 12: 10.1074/mcp.M113.029041, 3036-3051, 2013. C1 [Memisevic, Vesna; Zavaljevski, Nela; Yu, Chenggang; Yu, Xueping; Reifman, Jaques; Wallqvist, Anders] US Army, Dept Def Biotechnol, High Performance Comp Software Applicat Inst, Telemed & Adv Technol Res Ctr,Med Res & Mat Comma, Ft Detrick, MD 21702 USA. [Pieper, Rembert; Rajagopala, Seesandra V.; Kwon, Keehwan; Townsend, Katherine] J Craig Venter Inst, Rockville, MD 20850 USA. [DeShazer, David] US Army, Bacteriol Div, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. RP Reifman, J (reprint author), US Army, Dept Def Biotechnol, High Performance Comp Software Applicat Inst, Telemed & Adv Technol Res Ctr,Med Res & Mat Comma, Ft Detrick, MD 21702 USA. EM jaques.reifman.civ@mail.mil RI Luan, Gan/B-3211-2015; OI wallqvist, anders/0000-0002-9775-7469 FU Defense Threat Reduction Agency [CBS.MEDBIO.02.10.BH.021] FX This work was supported by the Defense Threat Reduction Agency (project CBS.MEDBIO.02.10.BH.021). NR 100 TC 13 Z9 13 U1 0 U2 11 PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3996 USA SN 1535-9476 EI 1535-9484 J9 MOL CELL PROTEOMICS JI Mol. Cell. Proteomics PD NOV PY 2013 VL 12 IS 11 BP 3036 EP 3051 DI 10.1074/mcp.M113.029041 PG 16 WC Biochemical Research Methods SC Biochemistry & Molecular Biology GA 277JX UT WOS:000328816000003 PM 23800426 ER PT J AU Brusseau, ML Carroll, KC Truex, MJ Becker, DJ AF Brusseau, Mark L. Carroll, Kenneth C. Truex, Michael J. Becker, David J. TI Characterization and Remediation of Chlorinated Volatile Organic Contaminants in the Vadose Zone SO VADOSE ZONE JOURNAL LA English DT Article ID SOIL-VAPOR EXTRACTION; UNSATURATED POROUS-MEDIA; NONAQUEOUS PHASE LIQUID; PARTITIONING TRACER TESTS; 3-DIMENSIONAL NUMERICAL-MODEL; EVAPORATIVE MASS-TRANSFER; LOW-PERMEABILITY SOILS; WATER-CONTENT; IMMISCIBLE-LIQUID; HYDRAULIC TOMOGRAPHY AB Contamination of vadose-zone systems by chlorinated solvents is widespread and poses significant potential risk to human health through impacts on groundwater quality and vapor intrusion. Soil vapor extraction (SVE) is the presumptive remedy for such contamination and has been used successfully for innumerable sites; however, SVE operations typically exhibit reduced mass-removal effectiveness at some point due to the impact of poorly accessible contaminant mass and associated mass-transfer limitations. Assessment of SVE performance and closure is currently based on characterizing contaminant mass discharge associated with the vadose-zone source and its impact on groundwater or vapor intrusion. These issues are addressed in this overview, with a focus on summarizing recent advances in our understanding of the transport, characterization, and remediation of chlorinated solvents in the vadose zone. The evolution of contaminant distribution with time and the associated impacts on remediation efficiency are discussed, as is potential impact of persistent sources on groundwater quality and vapor intrusion. In addition, alternative methods for site characterization and remediation are addressed. C1 [Brusseau, Mark L.] Univ Arizona, Sch Earth & Environm Sci, Tucson, AZ 85721 USA. [Carroll, Kenneth C.; Truex, Michael J.] Pacific NW Natl Lab, Richland, WA 99354 USA. [Becker, David J.] US Army Corps Engineers, Environm & Munit Ctr Expertise, Omaha, NE 68102 USA. RP Brusseau, ML (reprint author), Univ Arizona, Sch Earth & Environm Sci, Tucson, AZ 85721 USA. EM Brusseau@email.arizona.edu RI Carroll, Kenneth/H-5160-2011 OI Carroll, Kenneth/0000-0003-2097-9589 FU U.S. Department of Defense Environmental Security Technology Certification Program [ER-201125]; USDOE Office of Environmental Management, Office of Soil and Groundwater Remediation and Office of Richland Operations; National Institute of Environmental Health Sciences Superfund Research Program [ES04940]; USDOE [DE-AC05-76RL01830] FX This research was supported by the U.S. Department of Defense Environmental Security Technology Certification Program (ER-201125), the USDOE Office of Environmental Management, Office of Soil and Groundwater Remediation and Office of Richland Operations, and the National Institute of Environmental Health Sciences Superfund Research Program (ES04940). We thank Jim Hatton of AECOM, Inc., and Manfred Plaschke of CRA, Inc., for graciously providing the SVE data sets for the AFP44 and TAA sites, respectively. Assistance with graphics from Kyle Parker and Jeff London is appreciated. The Pacific Northwest National Laboratory is operated by Battelle Memorial Institute for the USDOE under Contract DE-AC05-76RL01830. NR 145 TC 9 Z9 9 U1 3 U2 33 PU SOIL SCI SOC AMER PI MADISON PA 677 SOUTH SEGOE ROAD, MADISON, WI 53711 USA SN 1539-1663 J9 VADOSE ZONE J JI Vadose Zone J. PD NOV PY 2013 VL 12 IS 4 DI 10.2136/vzj2012.0137 PG 17 WC Environmental Sciences; Soil Science; Water Resources SC Environmental Sciences & Ecology; Agriculture; Water Resources GA 274TF UT WOS:000328628400002 ER PT J AU Jones, A AF Jones, Alvin TI Victoria Symptom Validity Test: Cutoff Scores for Psychometrically Defined Malingering Groups in a Military Sample SO CLINICAL NEUROPSYCHOLOGIST LA English DT Article DE Victoria Symptom Validity Test; VSVT; Military sample; Malingering ID TRAUMATIC BRAIN-INJURY; RESPONSE BIAS; TEST-PERFORMANCE; NEUROPSYCHOLOGICAL ASSESSMENT; REPEATABLE BATTERY; LIKELIHOOD RATIOS; SUSPECT EFFORT; EFFORT INDEX; HEAD-INJURY; MEMORY TEST AB The Victoria Symptom Validity Test (VSVT) is one of the least widely used tests to assess performance validity on tests of neurocognitive functioning, but a meta-analysis has suggested that it is one of the more effective validity tests. The current research examined cutoffs for several different scores derived from the VSVT in an active duty military sample composed primarily of mild TBI patients. The results are consistent with previous research and provide additional evidence that much higher cutoffs scores than originally recommended for the VSVT by the developers based on binomial probability theory can produce excellent classification and diagnostic statistics when a psychometrically defined non-malingering group is compared with two psychometrically defined malingering groups (Probable and Probable to Definite). The utility of the difference score between the Easy and Hard Items is supported by this research. The results also indicate that reaction times have some utility, but they are constrained by a lack of sensitivity. C1 Womack Army Med Ctr, Dept Brain Injury Med, Ft Bragg, NC 29310 USA. RP Jones, A (reprint author), Womack Army Med Ctr, Dept Brain Injury Med, 2817 Riley Rd,Bldg 4-2817, Ft Bragg, NC 29310 USA. EM alvin.jones2@us.army.mil NR 55 TC 5 Z9 5 U1 0 U2 6 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA SN 1385-4046 EI 1744-4144 J9 CLIN NEUROPSYCHOL JI Clin. Neuropsychol. PD NOV 1 PY 2013 VL 27 IS 8 BP 1373 EP 1394 DI 10.1080/13854046.2013.851740 PG 22 WC Psychology, Clinical; Clinical Neurology; Psychology SC Psychology; Neurosciences & Neurology GA 273KW UT WOS:000328534700011 PM 24161269 ER PT J AU Milojkovic, P Tompkins, S Athale, R AF Milojkovic, Predrag Tompkins, Stefanie Athale, Ravindra TI Gradient Index Optics SO OPTICAL ENGINEERING LA English DT Editorial Material C1 [Milojkovic, Predrag] US Army Res Lab, RDRL SEE E, Adelphi, MD 20783 USA. [Tompkins, Stefanie] DARPA, Arlington, VA 22203 USA. [Athale, Ravindra] Off Naval Res, EO IR, Arlington, VA 22203 USA. RP Milojkovic, P (reprint author), US Army Res Lab, RDRL SEE E, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM predrag.milojkovic.civ@mail.mil; stefanie.tompkins@darpa.mil; ravindra.athale@navy.mil NR 0 TC 2 Z9 2 U1 0 U2 5 PU SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98225 USA SN 0091-3286 EI 1560-2303 J9 OPT ENG JI Opt. Eng. PD NOV PY 2013 VL 52 IS 11 AR 112101 DI 10.1117/1.OE.52.11.112101 PG 2 WC Optics SC Optics GA 278NY UT WOS:000328898200003 ER PT J AU Woolley, AW Bear, JB Chang, JW DeCostanza, AH AF Woolley, Anita Williams Bear, Julia B. Chang, Jin Wook DeCostanza, Arwen Hunter TI The effects of team strategic orientation on team process and information search Preface SO ORGANIZATIONAL BEHAVIOR AND HUMAN DECISION PROCESSES LA English DT Editorial Material DE Team strategic orientation; Offense; Defense; Information search; Process focus; Group decision-making; Group adaptation ID GROUP DECISION-MAKING; TOP MANAGEMENT TEAMS; REGULATORY FOCUS; TASK COMPLEXITY; WORK TEAMS; PERFORMANCE; KNOWLEDGE; ORGANIZATIONS; ENVIRONMENTS; CAPABILITIES AB We tested the effects of team strategic orientation on team member perceptions, work strategy and information search. In Experiment 1, 80 teams worked on a hidden profile decision-making task. A defensive team strategic orientation increased members' perceptions of the problem's scope, leading to a more process-focused work strategy and broader information search compared to an offensive team strategic orientation. When teams needed critical information from the environment, defensive teams outperformed offensive teams; offensive teams performed better when critical information resided within the team. In Experiment 2, these findings were replicated with 92 teams performing a different decision task. When making a second decision, half of the teams were led to change their strategic orientation; teams shifting from offense to defense altered their information search behavior more readily than did teams shifting in the opposite direction, suggesting an asymmetric adaptation effect. (C) 2013 Elsevier Inc. All rights reserved. C1 [Woolley, Anita Williams; Chang, Jin Wook] Carnegie Mellon Univ, Tepper Sch Business, Pittsburgh, PA 15213 USA. [Bear, Julia B.] Technion Israel Inst Technol, IL-32000 Haifa, Israel. [DeCostanza, Arwen Hunter] US Army, Res Inst Behav & Social Sci, Adelphi, MD USA. RP Woolley, AW (reprint author), Carnegie Mellon Univ, Tepper Sch Business, Pittsburgh, PA 15213 USA. EM awoolley@cmu.edu NR 66 TC 3 Z9 3 U1 4 U2 30 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0749-5978 EI 1095-9920 J9 ORGAN BEHAV HUM DEC JI Organ. Behav. Hum. Decis. Process. PD NOV PY 2013 VL 122 IS 2 BP 114 EP 126 DI 10.1016/j.obhdp.2013.06.002 PG 13 WC Psychology, Applied; Management; Psychology, Social SC Psychology; Business & Economics GA 276AC UT WOS:000328719500002 ER PT J AU Metcalfe, GD Hirai, A Young, EC Speck, JS Shen, HE Wraback, M AF Metcalfe, Grace D. Hirai, Asako Young, Erin C. Speck, James S. Shen, Hongen Wraback, Michael TI Terahertz studies of carrier localization in spontaneously forming polar lateral heterostructures SO PHYSICA STATUS SOLIDI-RAPID RESEARCH LETTERS LA English DT Article DE III-nitride semiconductors; terahertz emission spectroscopy; lateral heterostructures; carrier localization; GaN ID QUANTUM-WELL STRUCTURES; STACKING-FAULTS; BAND-GAP; GAAS; SUSCEPTIBILITY; CONFINEMENT; TRANSITIONS; GENERATION; RADIATION; SURFACES AB We employ near-bandgap terahertz emission spectroscopy to study lateral heterostructures resulting from basal plane stacking faults in m -plane GaN. The predominant stacking faults have I-1 character and behave as an array of spontaneously forming layers comprised of a single cubic stacking sequence within the wurtzite matrix that terminate the spontaneous polarization along the in-plane c-axis, leading to strong lateral electric fields. Spectral tuning of femtosecond excitation pulses enables observation of the transition from carrier transport in the continuum to formation of instantaneous dipoles and nonlinear susceptibility associated with both the quantum-well-like regions of the cubic layers and polarization-induced triangular-like potentials. ((c) 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim) C1 [Metcalfe, Grace D.; Shen, Hongen; Wraback, Michael] US Army Res Lab, Sensors & Electron Devices Directorate, RDRL SEE M, Adelphi, MD 20783 USA. [Hirai, Asako; Young, Erin C.; Speck, James S.] Univ Calif Santa Barbara, Dept Mat, Santa Barbara, CA 93106 USA. RP Metcalfe, GD (reprint author), US Army Res Lab, Sensors & Electron Devices Directorate, RDRL SEE M, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM grace.d.metcalfe.civ@mail.mil NR 25 TC 0 Z9 0 U1 0 U2 8 PU WILEY-V C H VERLAG GMBH PI WEINHEIM PA BOSCHSTRASSE 12, D-69469 WEINHEIM, GERMANY SN 1862-6254 EI 1862-6270 J9 PHYS STATUS SOLIDI-R JI Phys. Status Solidi-Rapid Res. Lett. PD NOV PY 2013 VL 7 IS 11 BP 993 EP 996 DI 10.1002/pssr.201308099 PG 4 WC Materials Science, Multidisciplinary; Physics, Applied; Physics, Condensed Matter SC Materials Science; Physics GA 270ME UT WOS:000328321700014 ER PT J AU Swierczewski, BE Odundo, EA Koech, MC Ndonye, JN Kirera, RK Odhiambo, CP Cheruiyot, EK Shaffer, DN Ombogo, AN Oaks, EV AF Swierczewski, Brett E. Odundo, Elizabeth A. Koech, Margaret C. Ndonye, Janet N. Kirera, Ronald K. Odhiambo, Cliff P. Cheruiyot, Erick K. Shaffer, Douglas N. Ombogo, Abigael N. Oaks, Edwin V. TI Enteric pathogen surveillance in a case-control study of acute diarrhoea in the town of Kisii, Kenya SO JOURNAL OF MEDICAL MICROBIOLOGY LA English DT Letter ID WESTERN KENYA C1 [Swierczewski, Brett E.; Odundo, Elizabeth A.; Koech, Margaret C.; Ndonye, Janet N.; Kirera, Ronald K.; Odhiambo, Cliff P.; Cheruiyot, Erick K.; Shaffer, Douglas N.; Ombogo, Abigael N.] US Army Med Res Unit Kenya, Kericho Field Stn, Kericho 20220, Kenya. [Swierczewski, Brett E.; Oaks, Edwin V.] Walter Reed Army Inst Res, Bacterial Dis Branch, Silver Spring, MD 20910 USA. RP Swierczewski, BE (reprint author), US Army Med Res Unit Kenya, Kericho Field Stn, POB 1357 Hosp Rd, Kericho 20220, Kenya. EM brett.swierczewski@us.army.mil NR 7 TC 1 Z9 1 U1 0 U2 3 PU SOC GENERAL MICROBIOLOGY PI READING PA MARLBOROUGH HOUSE, BASINGSTOKE RD, SPENCERS WOODS, READING RG7 1AG, BERKS, ENGLAND SN 0022-2615 EI 1473-5644 J9 J MED MICROBIOL JI J. Med. Microbiol. PD NOV PY 2013 VL 62 BP 1774 EP 1776 DI 10.1099/jmm.0.059139-0 PN 11 PG 3 WC Microbiology SC Microbiology GA 270GG UT WOS:000328306300022 PM 23842139 ER PT J AU Bourne, AR Mohan, G Stone, MF Pham, MQ Schultz, CR Meyerhoff, JL Lumley, LA AF Bourne, A. R. Mohan, G. Stone, M. F. Pham, M. Q. Schultz, C. R. Meyerhoff, J. L. Lumley, L. A. TI Olfactory cues increase avoidance behavior and induce Fos expression in the amygdala, hippocampus and prefrontal cortex of socially defeated mice SO BEHAVIOURAL BRAIN RESEARCH LA English DT Article DE Social stress; Basolateral amygdala; Hippocampus; Prefrontal cortex; Avoidance; Fos ID POSTTRAUMATIC-STRESS-DISORDER; BASOLATERAL AMYGDALA; MALE-RATS; MEMORY; BRAIN; FEAR; PTSD; CONSOLIDATION; ACTIVATION; ADAPTATION AB Genes and proteins of the Fos family are used as markers of neuronal activity and can be modulated by stress. This study investigated whether social defeat (SD) or exposure to an olfactory cue associated with the SD experience activated Fos and FosB/DeltaFosB (Delta FosB) expression in brain regions implicated in the development of post-traumatic stress disorder. Mice exposed to acute SD showed more Fos positive cells in the basolateral amygdala (BLA), CA1 of the hippocampus and the medial prefrontal cortex (mPFC) 1 h after SD, and had greater expression of the more persistent FosB/Delta FosB protein in the BLA 24h after SD compared to controls. Mice exposed to an olfactory cue 24 h or 7 days after SD had higher levels of Fos expression in all three regions 1 h after exposure to the cue, and displayed increased avoidance behavior compared to controls. While the avoidance response dissipated with time (less at 7 day vs 24 h after social defeat), Fos expression in the mPFC and CA1 in response to an olfactory cue was greater at 7 days relative to 24 h after social defeat. The results suggest additional processing of the cue-stress association and may provide further support for a role of the mPFC in fear inhibition. These findings may have implications for brain regions and circuitry involved in the avoidance of cues associated with a stressful event that may lead to context-dependent adaptive or maladaptive behavior. Published by Elsevier B.V. C1 [Bourne, A. R.; Mohan, G.; Stone, M. F.; Pham, M. Q.; Schultz, C. R.; Meyerhoff, J. L.; Lumley, L. A.] US Army Med Res Inst Chem Def, Aberdeen Proving Ground, MD 21010 USA. RP Lumley, LA (reprint author), US Army Med Res Inst Chem Def, Analyt Toxicol Div, 3100 Ricketts Point Rd, Aberdeen Proving Ground, MD 21010 USA. EM lucille.a.lange.civ@mail.mil FU U.S. Army Medical Research and Materiel Command FX This research was supported by the U.S. Army Medical Research and Materiel Command. The authors appreciate the editorial comments of Carl Smith, Cindy Kronman, Gary Rockwood and Sarah Sanjakdar. Andrew Bourne and Caroline Schultz were supported by appointments to the Student/ Postdoctoral Research Participation Program at the U.S. Army Medical Research Institute of Chemical Defense administered by the Oak Ridge Institute for Science and Education through an interagency appointment between the U.S. Department of Energy and USAMRMC. NR 58 TC 4 Z9 4 U1 1 U2 6 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0166-4328 EI 1872-7549 J9 BEHAV BRAIN RES JI Behav. Brain Res. PD NOV 1 PY 2013 VL 256 BP 188 EP 196 DI 10.1016/j.bbr.2013.08.020 PG 9 WC Behavioral Sciences; Neurosciences SC Behavioral Sciences; Neurosciences & Neurology GA 267JO UT WOS:000328094100023 PM 23968590 ER PT J AU Brunye, TT Howe, JL Kimball, BR Eddy, MD Mahoney, CR AF Brunye, Tad T. Howe, Jessica L. Kimball, Brian R. Eddy, Marianna D. Mahoney, Caroline R. TI Variable transmission lens influences on the dynamics of pupillary light reflexes SO ERGONOMICS LA English DT Article DE adaptive eyewear; light transmission; pupillary light reflex; vision ID EYE; CONSTRICTION; PERFORMANCE; SUNGLASSES; DILATION; LATENCY; DISEASE AB This study examined the influence of liquid crystal variable transmission lenses on pupillary light reflexes in response to sudden bright light onset. Participants were exposed to bright light while pupil size was monitored using an eye tracker; eyewear was configured across four transition conditions: constant low-light filtering, constant high-light filtering, variable-light filtering in response to light detection and a control condition without eyewear. Before light onset, pupil diameter was largest in the high-filter condition, medium in the variable- and low-light filtering conditions and smallest in the control condition. Following light onset, the low-light filtering and control conditions, and the high-light filtering and variable-light filtering conditions converged over time. Critically, automatically transitioning between low- and high-light filtering reduced the magnitude (approximately 0.2mm) and duration (approximately 360ms) of the pupillary response relative to constant low-light filtering. Practitioner Summary: Emerging civilian and specialised industrial and military eyewear technologies incorporating variable transmission lenses quickly and automatically adapt lens tints to environmental lighting conditions. We demonstrate that this technology alters the dynamics of pupillary light reflexes, optimising the efficiency with which humans can adapt to sudden changes in environmental lighting. C1 [Brunye, Tad T.; Howe, Jessica L.; Eddy, Marianna D.; Mahoney, Caroline R.] US Army Natick Soldier Res, Cognit Sci Team, RDNS WSH S, Ctr Dev & Engn, Natick, MA 01760 USA. [Brunye, Tad T.; Eddy, Marianna D.; Mahoney, Caroline R.] Tufts Univ, Dept Psychol, Medford, MA 02155 USA. [Kimball, Brian R.] US Army Natick Soldier Res, Nanomat Sci Team, Ctr Dev & Engn, Natick, MA 01760 USA. RP Brunye, TT (reprint author), US Army Natick Soldier Res, Cognit Sci Team, RDNS WSH S, Ctr Dev & Engn, Natick, MA 01760 USA. EM thaddeus.brunye@us.army.mil NR 25 TC 0 Z9 0 U1 1 U2 10 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 0014-0139 EI 1366-5847 J9 ERGONOMICS JI Ergonomics PD NOV 1 PY 2013 VL 56 IS 11 BP 1745 EP 1753 DI 10.1080/00140139.2013.832806 PG 9 WC Engineering, Industrial; Ergonomics; Psychology, Applied; Psychology SC Engineering; Psychology GA 269LC UT WOS:000328241800011 PM 24041334 ER PT J AU Garneau, CJ Parkinson, MB AF Garneau, Christopher J. Parkinson, Matthew B. TI Considering just noticeable difference in assessments of physical accommodation for product design SO ERGONOMICS LA English DT Article DE just noticeable difference (JND); designing for human variability (DfHV); user sensitivity; anthropometry; physical accommodation ID SENSITIVITY; PERCEPTION; JND AB Configuring products or environments for the size of their human users requires the consideration of several characteristics of the target user population, including body dimensions (anthropometry) and preferred interaction. Users are both adaptable and imperfect observers, which often makes it difficult for them to distinguish between candidate designs. This insensitivity is described by a concept called just noticeable difference', or JND. This paper presents an implementation of JND modelling and demonstrates how its use in the sizing of products or environments for target user populations can improve expected performance. Two facets of this problem are explored: (1) how experimental measures of JND for dimensional optimisation tasks may be obtained, and (2) how measures of JND may be included in models of user-device interaction for both adjustable and discretely sized products and the assumptions required. A case study demonstrating the collection and modelling of JND for a simple univariate problem is also presented.Practitioner Summary: Since people are adaptable and imperfect observers, there exists a just noticeable difference' that can be considered when designing products and environments. When JND is modelled for a target population, less variability in design dimensions due to physical user requirements may be necessary. This paper considers JND in quantitative simulations of population accommodation. C1 [Garneau, Christopher J.] US Army Res Lab, Human Res & Engn Directorate, Aberdeen Proving Ground, MD 21005 USA. [Parkinson, Matthew B.] Penn State Univ, University Pk, PA 16802 USA. RP Garneau, CJ (reprint author), US Army Res Lab, Human Res & Engn Directorate, Aberdeen Proving Ground, MD 21005 USA. EM christopher.j.garneau.civ@mail.mil RI Parkinson, Matt/M-5073-2016 OI Parkinson, Matt/0000-0002-1710-387X FU National Science Foundation [0846373]; Science, Mathematics, & Research for Transformation (SMART) Program, part of The National Defense Education Program FX This research was partially funded by the National Science Foundation [award number 0846373]. It was also partially funded by the Science, Mathematics, & Research for Transformation (SMART) Program, which is part of The National Defense Education Program. Any opinions, findings and conclusions or recommendations expressed in this material are those of the authors and do not necessarily reflect the views of the National Science Foundation. NR 24 TC 1 Z9 1 U1 0 U2 9 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND SN 0014-0139 EI 1366-5847 J9 ERGONOMICS JI Ergonomics PD NOV 1 PY 2013 VL 56 IS 11 BP 1777 EP 1788 DI 10.1080/00140139.2013.838308 PG 12 WC Engineering, Industrial; Ergonomics; Psychology, Applied; Psychology SC Engineering; Psychology GA 269LC UT WOS:000328241800014 PM 24099095 ER PT J AU Delmerico, JA David, P Corso, JJ AF Delmerico, Jeffrey A. David, Philip Corso, Jason J. TI Building facade detection, segmentation, and parameter estimation for mobile robot stereo vision SO IMAGE AND VISION COMPUTING LA English DT Article DE Stereo vision; Mobile robot perception; Hierarchical Markov random field; Building facade detection; Model-based stereo vision ID ENERGY MINIMIZATION; TEXTURES; IMAGE AB Building facade detection is an important problem in computer vision, with applications in mobile robotics and semantic scene understanding. In particular, mobile platform localization and guidance in urban environments can be enabled with accurate models of the various building facades in a scene. Toward that end, we present a system for detection, segmentation, and parameter estimation of building facades in stereo imagery. The proposed method incorporates multilevel appearance and disparity features in a binary discriminative model, and generates a set of candidate planes by sampling and clustering points from the image with Random Sample Consensus (RANSAC), using local normal estimates derived from Principal Component Analysis (PCA) to inform the planar models. These two models are incorporated into a two-layer Markov Random Field (MRF): an appearance- and disparity-based discriminative classifier at the mid-level, and a geometric model to segment the building pixels into facades at the high-level. By using object-specific stereo features, our discriminative classifier is able to achieve substantially higher accuracy than standard boosting or modeling with only appearance-based features. Furthermore, the results of our MRF classification indicate a strong improvement in accuracy for the binary building detection problem and the labeled planar surface models provide a good approximation to the ground truth planes. (C) 2013 Elsevier B.V. All rights reserved. C1 [Delmerico, Jeffrey A.; Corso, Jason J.] SUNY Buffalo, Dept Comp Sci & Engn, Buffalo, NY 14260 USA. [David, Philip] Army Res Lab, Adelphi, MD 20783 USA. RP Delmerico, JA (reprint author), Univ Hawaii Manoa, Dept Mech Engn, 2540 Dole St,Holmes Hall 310, Honolulu, HI 96822 USA. EM jad12@buffalo.edu; philip.j.david4.civ@mail.mil; jcorso@buffalo.edu FU NSF [IIS-0845282]; DARPA [W911NF-10-2-0062]; ARO [W911NF-11-1-0090]; United States Army Research Laboratory FX The authors are grateful for the financial support provided in part by NSF CAREER IIS-0845282, DARPA W911NF-10-2-0062, and ARO Young Investigator W911NF-11-1-0090. We are also thankful to the support of the United States Army Research Laboratory. NR 36 TC 4 Z9 4 U1 2 U2 14 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0262-8856 EI 1872-8138 J9 IMAGE VISION COMPUT JI Image Vis. Comput. PD NOV PY 2013 VL 31 IS 11 BP 841 EP 852 DI 10.1016/j.imavis.2013.08.006 PG 12 WC Computer Science, Artificial Intelligence; Computer Science, Software Engineering; Computer Science, Theory & Methods; Engineering, Electrical & Electronic; Optics SC Computer Science; Engineering; Optics GA 268PX UT WOS:000328184100002 ER PT J AU O'Guinn, ML Turell, MJ Kengluecha, A Jaichapor, B Kankaew, P Miller, RS Endy, TP Jones, JW Coleman, RE Lee, JS AF O'Guinn, Monica L. Turell, Michael J. Kengluecha, Ampornpan Jaichapor, Boonsong Kankaew, Prasan Miller, R. Scott Endy, Timothy P. Jones, James W. Coleman, Russell E. Lee, John S. TI Field Detection of Tembusu Virus in Western Thailand by RT-PCR and Vector Competence Determination of Select Culex Mosquitoes for Transmission of the Virus SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID AMAZON BASIN REGION; JAPANESE ENCEPHALITIS; ARBOVIRUS INFECTIONS; EASTERN; CHINA; ISOLATIONS; SOUTHERN; BEHAVIOR; SARAWAK; DUCKS AB Tembusu virus (TMUV; Ntaya serocomplex) was detected in two pools of mosquitoes captured near Sangkhlaburi, Thailand, as well as from sera from sentinel ducks from the same area. Although TMUV has been isolated from several mosquito species in Asia, no studies have ever shown competent vectors for this virus. Therefore, we allowed mosquitoes captured near Sangkhlaburi to feed on young chickens that had been infected with TMUV. These mosquitoes were tested approximately 2 weeks later to determine infection, dissemination, and transmission rates. Culex vishnui developed high viral titers after feeding on TMUV-infected chicks and readily transmitted virus to naive chickens. In contrast, Cx. fuscocephala seemed less susceptible to infection, and more importantly, zero of five fuscocephala with a disseminated infection transmitted virus by bite, indicating a salivary gland barrier. These results provide evidence for the involvement of Culex mosquitoes in the transmission of TMUV in the environment. C1 [Turell, Michael J.] US Army, Med Res Inst Infect Dis, Div Virol, Frederick, MD 21701 USA. Armed Forces Res Inst Med Sci, Dept Entomol, Bangkok 10400, Thailand. RP Lee, JS (reprint author), Walter Reed Army Inst Res, Div Entomol, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM monica.oguinn@us.army.mil; michael.j.turell@us.army.mil; ampornpank@afrims.org; boonsongj@afrims.org; prasankankaew@yahoo.com; robert.s.miller@us.army.mil; russell.coleman@us.army; james.jones@afrims.org; russell.coleman@us.army; john.s.lee13@gmail.com OI Lee, John/0000-0001-7605-1814 FU US Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD; Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand; Military Infectious Disease Research Program [U0014_02_RD, U0014_03_RD] FX This work was supported through the joint partnership between the US Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD, and the Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand, and it was funded in part by the Military Infectious Disease Research Program Projects U0014_02_RD and U0014_03_RD. NR 25 TC 8 Z9 8 U1 0 U2 6 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 EI 1476-1645 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2013 VL 89 IS 5 BP 1023 EP 1028 DI 10.4269/ajtmh.13-0160 PG 6 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 251BZ UT WOS:000326904100036 PM 24043687 ER PT J AU Taylor, S Ringelberg, DB Dontsova, K Daghlian, CP Walsh, ME Walsh, MR AF Taylor, Susan Ringelberg, David B. Dontsova, Katerina Daghlian, Charles P. Walsh, Marianne E. Walsh, Michael R. TI Insights into the dissolution and the three-dimensional structure of insensitive munitions formulations SO CHEMOSPHERE LA English DT Article DE Insensitive munitions; DNAN; NTO; Raman spectroscopy; Dissolution; Micro-computed tomography ID TRANSFORM RAMAN-SPECTROSCOPY; PROPELLANT FORMULATIONS; ENERGETIC MATERIALS; 2,4-DINITROANISOLE; PERCHLORATE; RDX; HMX C1 [Taylor, Susan; Ringelberg, David B.; Walsh, Marianne E.; Walsh, Michael R.] US Army, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. [Dontsova, Katerina] Univ Arizona, Tucson, AZ 85721 USA. [Daghlian, Charles P.] Dartmouth Coll, EM Facil, Hanover, NH 03755 USA. RP Taylor, S (reprint author), US Army, Cold Reg Res & Engn Lab, 72 Lyme Rd, Hanover, NH 03755 USA. EM Susan.Taylor@erdc.usace.army.mil FU Strategic Environmental Remediation Development Program FX We thank Dr. Mark McPeek at Dartmouth College for use of his mu CT scanner, Erika Rivera at BAE systems for sending us manufactured samples of these compounds and Matt Brian at National Technical Systems for the detonation residues of IMX101. We also thank Drs. Andrea Leeson and Jeffrey Marqusee of The Strategic Environmental Remediation Development Program for funding this work and two anonymous reviewers whose comments helped to improve the paper. NR 22 TC 6 Z9 6 U1 3 U2 22 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0045-6535 EI 1879-1298 J9 CHEMOSPHERE JI Chemosphere PD NOV PY 2013 VL 93 IS 9 BP 1782 EP 1788 DI 10.1016/j.chemosphere.2013.06.011 PG 7 WC Environmental Sciences SC Environmental Sciences & Ecology GA 253SJ UT WOS:000327109300017 PM 23916749 ER PT J AU Liu, NT Batchinsky, AI Cancio, LC Salinas, J AF Liu, Nehemiah T. Batchinsky, Andriy I. Cancio, Leopoldo C. Salinas, Jose TI The impact of noise on the reliability of heart-rate variability and complexity analysis in trauma patients SO COMPUTERS IN BIOLOGY AND MEDICINE LA English DT Article DE Signal detection analysis; Heart rate variability; Heart rate complexity; Clinical decision support systems; Automatic data processing; Electrocardiogram ID APPROXIMATE ENTROPY; NONLINEAR DYNAMICS; PREDICTION; SURVIVAL; INDEXES AB This study focused on the impact of noise on the reliability of heart-rate variability and complexity (HRV, HRC) to discriminate between different trauma patients and to monitor individual patients. Life-saving interventions (LSIs) were chosen as an endpoint because performance of LSIs is a critical aspect of trauma patient care. Noise was modeled and simulated by modifying original R-R interval (RRI) sequences via decimation, concatenation, and division of RRIs, as well as R-wave detection using the electrocardiogram. Results showed that under increasing simulated noise, entropy and autocorrelation measures can still effectively discriminate between LSI and non-LSI patients and monitor individuals over time. (C) 2013 Elsevier Ltd. All rights reserved. C1 [Liu, Nehemiah T.; Batchinsky, Andriy I.; Cancio, Leopoldo C.; Salinas, Jose] US Army, Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Liu, NT (reprint author), US Army, Inst Surg Res, 3650 Chambers Pass,Bldg 3610, Ft Sam Houston, TX 78234 USA. EM nehemiah.liu@us.army.mil; andriy.batchinsky1@us.army.mil; lee.cancio@us.army.mil; jose.salinas4@us.army.mil FU U.S. Army Combat Casualty Care Research Program FX This work was supported by the U.S. Army Combat Casualty Care Research Program. The authors thank Corina Necsoiu and Kerfoot Walker III, who performed the manual verification of all R waves for 108 trauma patient records in the Trauma Vitals database. NR 27 TC 3 Z9 4 U1 1 U2 5 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0010-4825 EI 1879-0534 J9 COMPUT BIOL MED JI Comput. Biol. Med. PD NOV 1 PY 2013 VL 43 IS 11 BP 1955 EP 1964 DI 10.1016/j.compbiomed.2013.09.012 PG 10 WC Biology; Computer Science, Interdisciplinary Applications; Engineering, Biomedical; Mathematical & Computational Biology SC Life Sciences & Biomedicine - Other Topics; Computer Science; Engineering; Mathematical & Computational Biology GA 260ES UT WOS:000327578400034 PM 24209941 ER PT J AU Desouki, MM Lloyd, J Xu, HD Cao, DF Barner, R Zhao, CQ AF Desouki, Mohamed Mokhtar Lloyd, Joshua Xu, Haodong Cao, Dengfeng Barner, Ross Zhao, Chengquan TI CDX2 may be a useful marker to distinguish primary ovarian carcinoid from gastrointestinal metastatic carcinoids to the ovary SO HUMAN PATHOLOGY LA English DT Article DE Ovary; Carcinoid; Immunohistochemistry; CDX2; Neuroendocrine ID SERTOLI-CELL TUMOR; CLINICOPATHOLOGICAL ANALYSIS; IMMUNOHISTOCHEMICAL SURVEY; NEUROENDOCRINE TUMORS; TRANSCRIPTION; ORIGIN; GENE; EXPRESSION; INTESTINE; PULMONARY AB Primary ovarian carcinoids and metastatic tumors share similar morphologic features. Metastatic carcinoids must be excluded from primary ones for prognostic and therapeutic reasons. Gastrointestinal neuroendocrine (carcinoid) tumors are much more common with the majority arising from small intestine and appendix. The aim of this study is to evaluate the role of immunohistochemistry for CDX2 in differentiating primary ovarian from metastatic carcinoids of primary gastrointestinal origin. Thirty primary pure ovarian carcinoids, 16 primary ovarian carcinoids arising in association with benign teratomas, 10 ovarian carcinoids metastatic from primary gastrointestinal tract and 70 gastrointestinal neuroendocrine tumors were studied for the expression of CDX2 by immunohistochemistry. CDX2 expression revealed that 40 (57.1%) of 70 cases of gastrointestinal carcinoids and 9 (90%) of 10 ovarian metastatic carcinoids showed positive nuclear staining (diffuse or focal). On the other hand, 3 (18.8%) of 16 primary carcinoids with teratomatous elements showed weak positivity. Among the 70 gastrointestinal carcinoids, CDX2 was positive in 38 (90.5%) of 42 cases in the duodenum, small intestine, appendix, and only in 2 (11.8%) of 17 cases of colorectal carcinoids and none of the 11 cases in the stomach. It is concluded that CDX2 may be a useful marker to distinguish primary ovarian carcinoid from metastasis from small intestinal and appendiceal neuroendocrine tumors. (C) 2013 Elsevier Inc. All rights reserved. C1 [Desouki, Mohamed Mokhtar; Lloyd, Joshua; Zhao, Chengquan] Univ Pittsburgh, Dept Pathol, Med Ctr, Magee Womens Hosp, Pittsburgh, PA 15213 USA. [Xu, Haodong] Univ Rochester, Rochester, NY 14642 USA. [Cao, Dengfeng] Peking Univ, Key Lab Carcinogenesis & Translat Res, Canc Hosp & Inst, Beijing 100142, Peoples R China. [Barner, Ross] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [Barner, Ross; Zhao, Chengquan] Armed Force Inst Pathol, Dept Gynecol Breast Pathol, Washington, DC USA. RP Zhao, CQ (reprint author), Magee Womens Hosp, Dept Pathol, 300 Halket St, Pittsburgh, PA 15213 USA. EM zhaoc@upmc.edu NR 35 TC 2 Z9 3 U1 0 U2 3 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0046-8177 EI 1532-8392 J9 HUM PATHOL JI Hum. Pathol. PD NOV PY 2013 VL 44 IS 11 BP 2536 EP 2541 DI 10.1016/j.humpath.2013.06.014 PG 6 WC Pathology SC Pathology GA 261SB UT WOS:000327683800020 PM 24029704 ER PT J AU Fan, KB Zhao, XG Zhang, JD Geng, K Keiser, GR Seren, HR Metcalfe, GD Wraback, M Zhang, X Averitt, RD AF Fan, Kebin Zhao, Xiaoguang Zhang, Jingdi Geng, Kun Keiser, George R. Seren, Huseyin R. Metcalfe, Grace D. Wraback, Michael Zhang, Xin Averitt, Richard D. TI Optically Tunable Terahertz Metamaterials on Highly Flexible Substrates SO IEEE TRANSACTIONS ON TERAHERTZ SCIENCE AND TECHNOLOGY LA English DT Article DE Metamaterial; optical tuning; spectroscopy ID STRETCHABLE ELECTRONICS; DEVICES; TUNABILITY; EYE AB We present optically tunable metamaterials (MMs) on flexible polymer sheets operating at terahertz (THz) frequencies. The flexible MMs, consisting of electric split-ring resonators (eSRRs) on patterned GaAs patches, were fabricated on a thin polyimide layer using a transfer technique. Optical excitation of the GaAs patches modifies the metamaterial response. Our experimental results revealed that, with increasing fluence, a transmission modulation depth of similar to 60% was achieved at the LC resonant frequency of 0.98 THz. In addition, a similar modulation depth was obtained over a broad range from 1.1 to 1.8 THz. Numerical simulations agree with experiment and indicate efficient tuning of the effective permittivity of the MMs. Our flexible tunable device paves the way to create multilayer nonplanar tunable electromagnetic composites for nonlinear and multifunctional applications, including sensing, modulation, and energy harvesting. C1 [Fan, Kebin; Zhao, Xiaoguang; Seren, Huseyin R.; Zhang, Xin] Boston Univ, Dept Mech Engn, Boston, MA 02215 USA. [Zhang, Jingdi; Geng, Kun; Keiser, George R.; Averitt, Richard D.] Boston Univ, Dept Phys, Boston, MA 02215 USA. [Metcalfe, Grace D.; Wraback, Michael] US Army Res Lab, Adelphi, MD 20783 USA. RP Fan, KB (reprint author), Boston Univ, Dept Mech Engn, Boston, MA 02215 USA. EM kbfan@bu.edu; zhaoxg@bu.edu; jdzhang@buphy.bu.edu; kgeng@bu.edu; grkeiser@buphy.bu.edu; hseren@bu.edu; grace.d.metcalfe.civ@mail.mil; michael.wraback.civ@mail.mil; xinz@bu.edu; raveritt@physics.bu.edu RI Zhang, Xin/B-9244-2009; Fan, Kebin/B-2984-2012 OI Zhang, Xin/0000-0002-4413-5084; Fan, Kebin/0000-0002-0275-0871 FU Air Force Office of Scientific Research [FA9550-09-1-0708]; National Science Foundation [ECCS 0802036]; DTRA [W911NF-06-2-0040] FX This work was supported in part by the Air Force Office of Scientific Research under Contract FA9550-09-1-0708, the National Science Foundation under Contract ECCS 0802036, and DTRA under Contract W911NF-06-2-0040 administered by the Army Research Laboratory. NR 50 TC 23 Z9 25 U1 2 U2 56 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 2156-342X J9 IEEE T THZ SCI TECHN JI IEEE Trans. Terahertz Sci. Technol. PD NOV PY 2013 VL 3 IS 6 SI SI BP 702 EP 708 DI 10.1109/TTHZ.2013.2285619 PG 7 WC Engineering, Electrical & Electronic; Optics; Physics, Applied SC Engineering; Optics; Physics GA 262GZ UT WOS:000327723600007 ER PT J AU Spaulding, NE Higgins, JA Kurbatov, AV Bender, ML Arcone, SA Campbell, S Dunbar, NW Chimiak, LM Introne, DS Mayewski, PA AF Spaulding, Nicole E. Higgins, John A. Kurbatov, Andrei V. Bender, Michael L. Arcone, Steven A. Campbell, Seth Dunbar, Nelia W. Chimiak, Laura M. Introne, Douglas S. Mayewski, Paul A. TI Climate archives from 90 to 250 ka in horizontal and vertical ice cores from the Allan Hills Blue Ice Area, Antarctica SO QUATERNARY RESEARCH LA English DT Article DE Marine Oxygen Isotope Stage 5.5; Marine Oxygen Isotope Stage 7; Termination II; Termination III; Blue ice area; Allan Hills; delta D; Ar-40(atm); delta O-18(atm); Ice core ID WEST ANTARCTICA; EAST ANTARCTICA; ROSS EMBAYMENT; WATER ISOTOPES; NORTH-ATLANTIC; GLACIAL CYCLES; MOUNT-MOULTON; TAYLOR DOME; POLAR ICE; RECORD AB Terrestrial meteorite ages indicate that some ice at the Allan Hills blue ice area (AH BIA) may be as old as 22 Ma. As such, ice from the AH BIA could potentially be used to extend the ice core record of paleoclimate beyond 800 ka. We collected samples from 5 to 10 cm depth along a 5 km transect through the main icefield and drilled a 225 m ice core (S27) at the midpoint of the transect to develop the climate archive of the AH BIA. Stable water isotope measurements (delta D) of the surface chips and of ice core S27 yield comparable signals, indicating that the climate record has not been significantly altered in the surface ice. Measurements of Ar-40(atm) and delta O-18(atm) taken from ice core S27 and eight additional shallow ice cores constrain the age of the ice to approximately 90-250 ka. Our findings provide a framework around which future investigations of potentially older ice in the AH BIA could be based. (C) 2013 University of Washington. Published by Elsevier Inc. All rights reserved. C1 [Spaulding, Nicole E.; Kurbatov, Andrei V.; Campbell, Seth; Introne, Douglas S.; Mayewski, Paul A.] Univ Maine, Climate Change Inst, Sch Earth & Climate Sci, Orono, ME 04469 USA. [Higgins, John A.; Bender, Michael L.; Chimiak, Laura M.] Princeton Univ, Dept Geosci, Princeton, NJ 08544 USA. [Campbell, Seth] US Army Cold Reg Res & Engn Lab, Hanover, NH USA. [Dunbar, Nelia W.] New Mexico Inst Min & Technol, Earth & Environm Sci Dept, Socorro, NM USA. RP Spaulding, NE (reprint author), Univ Maine, Climate Change Inst, Sch Earth & Climate Sci, Orono, ME 04469 USA. EM nicole.spaulding@maine.edu FU NSF [ANT-0838843, EAR-1027960] FX Funding for this work was provided by NSF grants ANT-0838843 and EAR-1027960. The authors wish to thank RPSC and Kenn Borek Air Ltd., Kristin Schild, Melissa Rohde, Audrey Yau, Mike Waszkiewicz, Calum Hamilton, Daniel Lesser and Ashley Suitter for logistical, field, and laboratory assistance. The authors also wish to acknowledge two anonymous reviewers whose insightful comments contributed greatly to the quality of this manuscript. NR 78 TC 3 Z9 3 U1 3 U2 23 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0033-5894 EI 1096-0287 J9 QUATERNARY RES JI Quat. Res. PD NOV PY 2013 VL 80 IS 3 BP 562 EP 574 DI 10.1016/j.yqres.2013.07.004 PG 13 WC Geography, Physical; Geosciences, Multidisciplinary SC Physical Geography; Geology GA 256BU UT WOS:000327285500021 ER PT J AU Yim, JH Rodriguez-Santiago, V Williams, AA Gougousi, T Pappas, DD Hirvonen, JK AF Yim, Jacqueline H. Rodriguez-Santiago, Victor Williams, Andre A. Gougousi, Theodosia Pappas, Daphne D. Hirvonen, James K. TI Atmospheric pressure plasma enhanced chemical vapor deposition of hydrophobic coatings using fluorine-based liquid precursors SO SURFACE & COATINGS TECHNOLOGY LA English DT Article DE Plasma enhanced chemical vapor deposition (PECVD); Hydrophobic coating; Dielectric barrier discharge (DBD); Atmospheric pressure plasma jet (APPJ); Organofluorosilane; Fluorocarbon ID DIELECTRIC BARRIER DISCHARGE; SELF-ASSEMBLED MONOLAYERS; FLUOROCARBON THIN-FILMS; SURFACE MODIFICATION; POLYMERS; POLYMERIZATION; CHEMISTRY; ALUMINUM; SILICON; CVD AB In this work, an atmospheric pressure plasma jet (APPJ) was investigated for developing hydrophobic thin film coatings on ultra-high molecular weight polyethylene (UHMWPE) films. Fluoroalkyl silanes, (CH3CH2O)(3)SiCH2CH2(CF2)(7)CF3 and (CH3O)(3)SiCH2CH2CF3 and fluoroalyl silane, F(5)Arsi(ocH(2)cH(3))(3) monomers with different fluorocarbon chain lengths were polymerized via plasma enhanced chemical vapor deposition (PECVD). These precursors in addition to other deposition processing conditions such as electrode-substrate gap distance and deposition time were investigated to understand the influence these parameters have on the overall deposition characteristics and hydrophobic behavior of the as-deposited thin film coatings. Attenuated total reflectance-Fourier transform infrared (ATR-FTIR) and X-ray photoelectron spectroscopy (XPS) techniques revealed that the chemical composition of the coatings retained a bulk of the monomer chemistry, signifying a low degree of fragmentation of the precursor in the plasma. This was particularly demonstrated by the coatings obtained with the fluoroaryl silane precursor, where the aromatic structure was kept intact. The hydrophobicity of the coatings was assessed using water contact angle (WCA) measurements and the thickness and morphology were examined using profilometry, scanning electron microscopy (SEM) and atomic force microscopy (AFM). Variations in the composition of fluorocarbon coatings were observed as a result of deposition conditions, however the dominant parameter was found to be the monomer precursor. Optimal hydrophobic behavior was observed from coatings derived from the monomer with the longest fluorocarbon chain, as demonstrated from trends seen in WCA and CFn group concentrations. (C) 2013 Elsevier B.V. All rights reserved. C1 [Yim, Jacqueline H.; Rodriguez-Santiago, Victor; Williams, Andre A.; Pappas, Daphne D.; Hirvonen, James K.] US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA. [Gougousi, Theodosia] Univ Maryland Baltimore Cty, Dept Phys, Baltimore, MD 21250 USA. RP Yim, JH (reprint author), US Army Res Lab, 4600 Deer Creek Loop, Aberdeen Proving Ground, MD 21005 USA. EM jacqueline.h.yim.ctr@mail.mil RI Gougousi, Theodosia/C-8156-2014; OI Rodriguez-Santiago, Victor/0000-0002-8389-5414 FU U.S. Army Research Laboratory FX This research was supported in part by an appointment to the Postgraduate Research Program at the U.S. Army Research Laboratory administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the U.S. Department of Energy and USARL. NR 44 TC 25 Z9 25 U1 5 U2 75 PU ELSEVIER SCIENCE SA PI LAUSANNE PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND SN 0257-8972 J9 SURF COAT TECH JI Surf. Coat. Technol. PD NOV PY 2013 VL 234 BP 21 EP 32 DI 10.1016/j.surfcoat.2013.03.028 PG 12 WC Materials Science, Coatings & Films; Physics, Applied SC Materials Science; Physics GA 261OM UT WOS:000327674500005 ER PT J AU Morton, R Krakover, B Hudson, T Alexander, B AF Morton, Richard, Jr. Krakover, Brian Hudson, Timothy Alexander, Brian TI CASUALTY EVACUATION: AN INNOVATIVE ROLE FOR EMERGENCY NURSES SO JOURNAL OF EMERGENCY NURSING LA English DT Article C1 [Morton, Richard, Jr.] Landstuhl Reg Med Ctr, Landstuhl, Germany. [Krakover, Brian] 5th Special Forces Grp, Ft Campbell, KY USA. [Hudson, Timothy] US Army War Coll, Carlisle, PA USA. [Alexander, Brian] US Army Sch Aviat Med, Joint Enroute Care Course, Ft Rucker, AL USA. RP Morton, R (reprint author), Landstuhl Reg Med Ctr, CMR 402,BOX 405, APO, AE USA. EM richard.t.morton.mil@mail.mil NR 2 TC 1 Z9 1 U1 1 U2 3 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0099-1767 EI 1527-2966 J9 J EMERG NURS JI J. Emerg. Nurs. PD NOV PY 2013 VL 39 IS 6 BP 576 EP 580 DI 10.1016/j.jen.2013.08.005 PG 5 WC Emergency Medicine; Nursing SC Emergency Medicine; Nursing GA 254EG UT WOS:000327146600013 PM 24075147 ER PT J AU Lewis, PC AF Lewis, Paul C. TI TOURNIQUETS: TRANSLATING MILITARY KNOWLEDGE INTO CIVILIAN CARE SO JOURNAL OF EMERGENCY NURSING LA English DT Article ID MAJOR LIMB TRAUMA; HEMORRHAGE CONTROL; LOCAL HYPOTHERMIA; DAMAGE CONTROL; RESUSCITATION; BATTLEFIELD; HISTORY C1 [Lewis, Paul C.] US Army Nurse Corps, Bethesda, MD USA. [Lewis, Paul C.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. RP Lewis, PC (reprint author), Grad Sch Nursing, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA. EM paul.lewis@usuhs.edu NR 31 TC 7 Z9 7 U1 0 U2 1 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0099-1767 EI 1527-2966 J9 J EMERG NURS JI J. Emerg. Nurs. PD NOV PY 2013 VL 39 IS 6 BP 595 EP 601 DI 10.1016/j.jen.2013.08.011 PG 7 WC Emergency Medicine; Nursing SC Emergency Medicine; Nursing GA 254EG UT WOS:000327146600016 PM 24090703 ER PT J AU Minnick, JM Bebarta, VS Stanton, M Lairet, JR King, J Torres, P Aden, J Ramirez, R AF Minnick, Joanne M. Bebarta, Vikhyat S. Stanton, Marietta Lairet, Julio R. King, James Torres, Pedro Aden, James Ramirez, Rosemarie TI THE INCIDENCE OF FEVER IN US CRITICAL CARE AIR TRANSPORT TEAM COMBAT TRAUMA PATIENTS EVACUATED FROM THE THEATER BETWEEN MARCH 2009 AND MARCH 2010 SO JOURNAL OF EMERGENCY NURSING LA English DT Article DE Fever; Flight medicine; Critical care transport; Trauma; Military medicine; Combat AB Introduction: Most critically ill injured patients are transported out of the theater by Critical Care Air Transport Teams (CCATTs). Fever after trauma is correlated with surgical complications and infection. The purposes of this study are to identify the incidence of elevated temperature in patients managed in the CCATT environment and to describe the complications reported and the treatments used in these patients. Methods: We performed a retrospective review of available records of trauma patients from the combat theater between March 1, 2009, and March 31, 2010, who were transported by the US Air Force CCATT and had an incidence of hyperthermia. We then divided the cohort into 2 groups, patients transported with an elevation in temperature greater than 100.4 degrees F and patients with no documented elevation in temperature. We used a standardized, secure electronic data collection form to abstract the outcomes. Descriptive data collected included injury type, temperature, use of a mechanical ventilator, cooling treatment modalities, antipyretics, intravenous fluid administration, and use of blood products. We also evaluated the incidence of complications during the transport in patients who had a recorded elevation in temperature greater than 100.4 degrees F. Results: A total of 248 trauma patients met the inclusion criteria, and 101 trauma patients (40%) had fever. The mean age was 28 years, and 98% of patients were men. The mechanism of injury was an explosion in 156 patients (63%), blunt injury in 11 (4%), and penetrating injury in 45 (18%), whereas other trauma-related injuries accounted for 36 patients (15%). Of the patients, 209 (84%) had battle-related injuries and 39 (16%) had non-battle-related injuries. Traumatic brain injury was found in 24 patients (24%) with an incidence of elevated temperature. The mean temperature was 101.6 degrees F (range, 100.5 degrees F-103.9 degrees F). After evaluation of therapies and treatments, 80 trauma patients (51%) were intubated on a mechanical ventilator (P < .001). Of the trauma patients with documented fever, 22 (22%) received administration of blood products. Nineteen patients received antipyretics during their flight (19%), 9 received intravenous fluids (9%), and 2 received nonpharmacologic cooling interventions, such as cooling blankets or icepacks. We identified 1 trauma patient with neurologic changes (1%), 6 with hypotension (6%), 48 with tachycardia (48%), 33 with decreased urinary output (33%), and 1 with an episode of shivering or sweating (1%). We did not detect any transfusion reactions or deaths during flight. Conclusion: Fever occurred in 41% of critically ill combat-injured patients evacuated out of the combat theater in Iraq and Afghanistan. Fewer than 20% of patients with a documented elevated temperature received treatments to reduce the temperature. Intubation of patients with ventilators in use during the transport was the only factor significantly associated with fever. Serious complications were rare, and there were no deaths during these transports. C1 [Minnick, Joanne M.; Torres, Pedro] US Army Inst Surg Res, Air Force Enroute Care Res Ctr, San Antonio, TX USA. [Minnick, Joanne M.; King, James; Torres, Pedro] Mil Med Ctr, Ft Sam Houston, TX USA. [Bebarta, Vikhyat S.] USAF, Enroute Care Res Ctr, Ft Sam Houston, TX USA. [Bebarta, Vikhyat S.] San Antonio Mil Med Ctr, Dept Emergency Med, Ft Sam Houston, TX USA. [Stanton, Marietta] Univ Alabama, Capstone Coll Nursing, Tuscaloosa, AL USA. [Lairet, Julio R.] Emory Univ, Dept Emergency Med, Atlanta, GA 30322 USA. [King, James] US Army Inst Surg Res, Air Force Enroute Care Res Ctr, Dept Emergency Med, San Antonio, TX USA. [Aden, James] US Army Inst Surg Res, Ft Sam Houston, TX USA. [Ramirez, Rosemarie] Wilford Hall Ambulatory Surg Ctr, MDW Off Chief Scientist 59, Lackland AFB, TX USA. RP Minnick, JM (reprint author), Enroute Care Res Ctr, 3698 Chambers Pass, Ft Sam Houston, TX 78234 USA. EM jodymm13@yahoo.com RI bebarta, vikhyat/K-3476-2015 NR 6 TC 2 Z9 2 U1 0 U2 5 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0099-1767 EI 1527-2966 J9 J EMERG NURS JI J. Emerg. Nurs. PD NOV PY 2013 VL 39 IS 6 BP E101 EP E106 DI 10.1016/j.jen.2013.02.001 PG 6 WC Emergency Medicine; Nursing SC Emergency Medicine; Nursing GA 254EG UT WOS:000327146600001 PM 23684131 ER PT J AU Croy, T Saliba, S Saliba, E Anderson, MW Hertel, J AF Croy, Theodore Saliba, Susan Saliba, Ethan Anderson, Mark W. Hertel, Jay TI Talofibular Interval Changes After Acute Ankle Sprain: A Stress Ultrasonography Study of Ankle Laxity SO JOURNAL OF SPORT REHABILITATION LA English DT Article DE imaging; joint instability; strain ID RANDOMIZED CONTROLLED-TRIAL; LIGAMENT INJURIES; STRAIN-MEASUREMENT; JOINT-COMPLEX; INSTABILITY; REHABILITATION; ULTRASOUND; ANATOMY; TRAUMA AB Introduction: Quantifying talocrural joint laxity after ankle sprain is problematic. Stress ultrasonography (US) can image the lateral talocrural joint and allow the measurement of the talofibular interval, which may suggest injury to the anterior talofibular ligament (ATFL). The acute talofibular interval changes after lateral ankle sprain are unknown. Methods: Twenty-five participants (9 male, 16 female; age 21.8 +/- 3.2 y, height 167.8 +/- 34.1 cm, mass 72.7 +/- 13.8 kg) with 27 acute, lateral ankle injuries underwent bilateral stress US imaging at baseline (<7 d) and on the affected ankle at 3 wk and 6 wk from injury in 3 ankle conditions: neutral, anterior drawer, and inversion. Talofibular interval (mm) was measured using imaging software and self-reported function (activities of daily living [ADL] and sports) by the Foot and Ankle Ability Measure (FAAM). Results: The talofibular interval increased with anterior-drawer stress in the involved ankle (22.65 +/- 3.75 mm; P = .017) over the uninvolved ankle (19.45 +/- 2.35 mm; limb x position F-1,F-26 = 4.9, P = .035) at baseline. Inversion stress also resulted in greater interval changes (23.41 +/- 2.81 mm) than in the uninvolved ankles (21.13 +/- 2.08 mm). A main effect for time was observed for inversion (F-2,F-52 = 4.3, P = .019, 21.93 +/- 2.24 mm) but not for anterior drawer (F-2,F-52 = 3.1, P =.055, 21.18 +/- 2.34 mm). A significant reduction in the talofibular interval took place between baseline and week 3 inversion measurements only (F-1,F-26 = 5.6, P = .026). FAAM-ADL and sports results increased significantly from baseline to wk 3 (21.9 +/- 16.2, P < .0001 and 23.8 +/- 16.9, P < .0001) and from wk 3 to wk 6 (2.5 +/- 4.4, P = .009 and 10.5 +/- 13.2, P = .001). Conclusions: Stress US methods identified increased talofibular interval changes suggestive of talocrural laxity and ATFL injury using anterior drawer and inversion stress that, despite significant improvements in self-reported function, only marginally improved during the 6 wk after ankle sprain. Stress US provides a safe, repeatable, and quantifiable method of measuring the talofibular interval and may augment manual stress examinations in acute ankle injuries. C1 [Croy, Theodore] US Army Baylor Univ, Doctoral Program Phys Therapy, Ft Sam Houston, TX 76798 USA. [Saliba, Susan; Saliba, Ethan; Hertel, Jay] Univ Virginia, Dept Kinesiol, Charlottesville, VA USA. [Anderson, Mark W.] Univ Virginia, Dept Radiol, Charlottesville, VA USA. RP Croy, T (reprint author), US Army Baylor Univ, Doctoral Program Phys Therapy, Ft Sam Houston, TX 76798 USA. OI Saliba, Susan/0000-0001-7179-8310 FU Retired Army Medical Specialist Corps Association (RAMSCA) FX Funding for this study was provided by the Retired Army Medical Specialist Corps Association (RAMSCA). NR 32 TC 2 Z9 2 U1 2 U2 8 PU HUMAN KINETICS PUBL INC PI CHAMPAIGN PA 1607 N MARKET ST, PO BOX 5076, CHAMPAIGN, IL 61820-2200 USA SN 1056-6716 EI 1543-3072 J9 J SPORT REHABIL JI J. Sport Rehabil. PD NOV PY 2013 VL 22 IS 4 BP 257 EP 263 PG 7 WC Rehabilitation; Sport Sciences SC Rehabilitation; Sport Sciences GA 256CQ UT WOS:000327287700004 PM 23689292 ER PT J AU Lee, LT AF Lee, Landris T., Jr. TI Expansive Clay Suction Measurements Using Filter Paper and Polymer-Capacitance Sensor Methods SO JOURNAL OF TESTING AND EVALUATION LA English DT Article DE relative humidity; swelling; shrinkage; potential movement; Yazoo clay; active zone AB Total suction values of undisturbed partially saturated expansive soil samples were synchronously measured using filter paper and miniature polymer-capacitance sensors. Soil suction-water content curves derived from enclosed headspace water vapor measurements were obtained for each method. Shrink-swell measurements were then correlated to the total suction values in order to demonstrate the applicability of either test method for estimating potential volume change. C1 US Army Engineer & Res Dev Ctr, Vicksburg, MS 39180 USA. RP Lee, LT (reprint author), US Army Engineer & Res Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. NR 15 TC 0 Z9 0 U1 2 U2 15 PU AMER SOC TESTING MATERIALS PI W CONSHOHOCKEN PA 100 BARR HARBOR DR, W CONSHOHOCKEN, PA 19428-2959 USA SN 0090-3973 EI 1945-7553 J9 J TEST EVAL JI J. Test. Eval. PD NOV PY 2013 VL 41 IS 6 BP 905 EP 913 DI 10.1520/JTE20120322 PG 9 WC Materials Science, Characterization & Testing SC Materials Science GA 257VA UT WOS:000327414700008 ER PT J AU Drost, RJ Moore, TJ Sadler, BM AF Drost, Robert J. Moore, Terrence J. Sadler, Brian M. TI Ultraviolet scattering propagation modeling: analysis of path loss versus range SO JOURNAL OF THE OPTICAL SOCIETY OF AMERICA A-OPTICS IMAGE SCIENCE AND VISION LA English DT Article ID LIGHT-EMITTING-DIODES; PERFORMANCE; COMMUNICATION AB Modeling of the complex atmospheric propagation of deep-ultraviolet (UV) radiation is important for applications such as non-line-of-sight (NLOS) UV communications. Building upon prior work in which it was observed that short-range, singly scattered NLOS path loss varies linearly with range, we formalize this relationship, generalizing it to consider any order of scattering and more-general system characteristics. In particular, we derive the approximate relationship PL proportional to r(2-n) between path loss PL and range r for nth-order scattered radiation, and investigate the region of validity of this approximation. Insight arising from the analysis can be invaluable in the development and study of UV systems, as demonstrated by numerical results that illustrate implications of the analysis. C1 [Drost, Robert J.; Moore, Terrence J.; Sadler, Brian M.] US Army, Res Lab, Adelphi, MD 20783 USA. RP Drost, RJ (reprint author), US Army, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM robert.j.drost6.civ@mail.mil NR 17 TC 6 Z9 7 U1 1 U2 6 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1084-7529 EI 1520-8532 J9 J OPT SOC AM A JI J. Opt. Soc. Am. A-Opt. Image Sci. Vis. PD NOV PY 2013 VL 30 IS 11 BP 2259 EP 2265 DI 10.1364/JOSAA.30.002259 PG 7 WC Optics SC Optics GA 254RP UT WOS:000327185000012 PM 24322923 ER PT J AU Hackley, J Sarney, WL Richardson, CJK AF Hackley, Justin Sarney, Wendy L. Richardson, Christopher J. K. TI Antimony-assisted carbonization of Si(111) with solid source molecular beam epitaxy SO JOURNAL OF VACUUM SCIENCE & TECHNOLOGY A LA English DT Article ID LOW-TEMPERATURE GROWTH; SI(001) SURFACE; SOURCE MBE; SI; INTERFACE; QUALITY; FILMS AB The carbonization of an antimony-terminated Si (111) surface in a solid source molecular beam epitaxy system is presented. Reflection high-energy electron diffraction, atomic force microscopy, x-ray photoelectron spectroscopy, and cross-sectional transmission electron microscopy are used to characterize samples grown with and without antimony termination. It is shown that the antimony-terminated surface promotes the formation of thin, smooth and continuous SiC films at a relatively low temperature of 800 degrees C. (C) 2013 American Vacuum Society. C1 [Hackley, Justin; Richardson, Christopher J. K.] Univ Maryland, Lab Phys Sci, College Pk, MD 20740 USA. [Sarney, Wendy L.] US Army, Res Lab, Adelphi, MD 20783 USA. RP Hackley, J (reprint author), Univ Maryland, Lab Phys Sci, College Pk, MD 20740 USA. EM jhackley@lps.umd.edu NR 27 TC 0 Z9 0 U1 0 U2 5 PU A V S AMER INST PHYSICS PI MELVILLE PA STE 1 NO 1, 2 HUNTINGTON QUADRANGLE, MELVILLE, NY 11747-4502 USA SN 0734-2101 J9 J VAC SCI TECHNOL A JI J. Vac. Sci. Technol. A PD NOV-DEC PY 2013 VL 31 IS 6 AR 061511 DI 10.1116/1.4822049 PG 6 WC Materials Science, Coatings & Films; Physics, Applied SC Materials Science; Physics GA 255QC UT WOS:000327253900036 ER PT J AU Shan, CS Zhao, WJ Lu, XL O'Brien, DJ Li, YP Cao, ZY Elias, AL Cruz-Silva, R Terrones, M Wei, BQ Suhr, J AF Shan, Changsheng Zhao, Wenjie Lu, X. Lucas O'Brien, Daniel J. Li, Yupeng Cao, Zeyuan Elias, Ana Laura Cruz-Silva, Rodolfo Terrones, Mauricio Wei, Bingqing Suhr, Jonghwan TI Three-Dimensional Nitrogen-Doped Multiwall Carbon Nanotube Sponges with Tunable Properties SO NANO LETTERS LA English DT Article DE Carbon nanotubes; mechanical and electrical properties; soft materials; CVD ID CATALYTIC PYROLYSIS; SULFUR; IMMOBILIZATION; NANOPARTICLES; GRAPHENE; STORAGE AB A three-dimensional (3D) nitrogen-doped multiwall carbon nanotube (N-MWCNT) sponge possessing junctions induced by both nitrogen and sulfur was synthesized by chemical vapor deposition (CVD). The formation of "elbow" junctions as well as "welded" junctions, which are attributed to the synergistic effect of the nitrogen dopant and the sulfur promoter, plays a critically important role in the formation of 3D nanotube sponges. To the best of our knowledge, this is the first report showing the synthesis of macroscale 3D N-MWCNT sponges. Most importantly, the diameter of N-MWCNT can be simply controlled by varying the concentration of sulfur, which in turn controls both the sponge's mechanical and its electrical properties. It was experimentally shown that, with increasing diameter of N-MWCNT, the elastic modulus of the sponge increased while the electrical conductivity decreased. The mechanical behaviors of the sponges have also been quantitatively analyzed by employing strain energy function modeling. C1 [Shan, Changsheng; Zhao, Wenjie] Univ Delaware, Ctr Composite Mat, Newark, DE 19716 USA. [Zhao, Wenjie; Lu, X. Lucas; Li, Yupeng; Cao, Zeyuan; Wei, Bingqing] Univ Delaware, Dept Mech Engn, Newark, DE 19716 USA. [O'Brien, Daniel J.] US Army Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. [Elias, Ana Laura; Terrones, Mauricio] Penn State Univ, Dept Phys, Davey Lab 104, University Pk, PA 16802 USA. [Elias, Ana Laura; Terrones, Mauricio] Penn State Univ, Ctr 2 Dimens & Layered Mat, Davey Lab 104, University Pk, PA 16802 USA. [Terrones, Mauricio] Penn State Univ, Dept Chem, Davey Lab 104, University Pk, PA 16802 USA. [Terrones, Mauricio] Penn State Univ, Dept Mat Sci & Engn, Davey Lab 104, University Pk, PA 16802 USA. [Cruz-Silva, Rodolfo; Terrones, Mauricio] Shinshu Univ, Res Ctr Exot Nanocarbons JST, Nagano 3808553, Japan. [Suhr, Jonghwan] Sungkyunkwan Univ, Dept Polymer Sci & Engn, Suwon 440746, South Korea. RP Wei, BQ (reprint author), Univ Delaware, Dept Mech Engn, Newark, DE 19716 USA. EM weib@udel.edu; suhr@skku.edu RI Wei, Bingqing/A-4525-2008; Terrones, Mauricio/B-3829-2014; Shan, Changsheng/F-1150-2015; Cruz-Silva, Rodolfo/A-2149-2012 OI Wei, Bingqing/0000-0002-9416-1731; Shan, Changsheng/0000-0001-7549-2386; Cruz-Silva, Rodolfo/0000-0002-6120-9524 FU U.S. Air Force Office of Scientific Research MURI Grant [FA9550-12-1-0035] FX This work was financially supported by the U.S. Air Force Office of Scientific Research MURI Grant (FA9550-12-1-0035) entitled "Synthesis and Characterization of 3-D Carbon Nanotube Solid Networks". NR 37 TC 46 Z9 49 U1 15 U2 188 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1530-6984 EI 1530-6992 J9 NANO LETT JI Nano Lett. PD NOV PY 2013 VL 13 IS 11 BP 5514 EP 5520 DI 10.1021/nl403109g PG 7 WC Chemistry, Multidisciplinary; Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied; Physics, Condensed Matter SC Chemistry; Science & Technology - Other Topics; Materials Science; Physics GA 253TH UT WOS:000327111700083 PM 24134742 ER PT J AU Niebuhr, DW Gubata, ME Oetting, AA Weber, NS Feng, XS Cowan, DN AF Niebuhr, David W. Gubata, Marlene E. Oetting, Alexis A. Weber, Natalya S. Feng, Xiaoshu Cowan, David N. TI Personality Assessment Questionnaire as a Pre-Accession Screen for Risk of Mental Disorders and Early Attrition in US Army Recruits SO PSYCHOLOGICAL SERVICES LA English DT Article DE mental health; personality tests; job performance; military health; preemployment screening ID HEALTH-CARE UTILIZATION; PSYCHIATRIC-DISORDERS; MILITARY PERSONNEL; AFGHANISTAN; IRAQ; DIMENSIONS; PREDICTION; MOTIVATION; SERVICES; WORK AB Personality assessment tools have been studied as predictors of performance in civilian and military work settings. The Tailored Adaptive Personality Assessment System (TAPAS) was developed to improve selection of new military recruits by predicting motivational outcomes such as job effort, physical fitness, and drive to perform at high standards. The purpose of this study is to examine the utility of TAPAS as a predictor of psychiatric morbidity and early discharge in a sample of 15,082 Army, active duty, enlisted, nonprior service recruits. Associations between TAPAS personality dimension score quintiles and mental disorder diagnoses, attrition, and health care utilization in United States Army recruits who took TAPAS in the fiscal year 2010 were analyzed using multivariate logistic regression and log-linear modeling. TAPAS physical conditioning dimension scores were predictive of mental disorder diagnosis and attrition, with TAPAS scorers in the lowest quintile at increased odds of early discharge (odds ratio [ OR]: 2.08, 95% CI 1.73, 2.51), mental disorder diagnosis (OR: 1.41, 95% CI 1.20, 1.66) and greater mental health care utilization (1.61, 95% CI 1.46, 1.78) compared with TAPAS scorers in the highest quintile. Results indicated that TAPAS may have an important use as a mental health fitness screening tool for those who wish to serve in the military by identifying a limited high risk group of applicants for mental health diagnostic evaluation. TAPAS may augment current cognitive and educational screens and potentially reduce the burden of mental disorders and premature attrition. C1 [Niebuhr, David W.; Gubata, Marlene E.; Oetting, Alexis A.; Weber, Natalya S.; Feng, Xiaoshu; Cowan, David N.] Walter Reed Army Inst Res, Dept Epidemiol, Prevent Med Branch, Silver Spring, MD 20910 USA. [Oetting, Alexis A.; Feng, Xiaoshu; Cowan, David N.] Allied Technol Grp Inc, Rockville, MD USA. RP Gubata, ME (reprint author), Walter Reed Army Inst Res, Dept Epidemiol, Prevent Med Branch, 503 Robert Grant Rd, Silver Spring, MD 20910 USA. EM marlene.gubata@us.army.mil NR 35 TC 3 Z9 3 U1 0 U2 8 PU AMER PSYCHOLOGICAL ASSOC PI WASHINGTON PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA SN 1541-1559 EI 1939-148X J9 PSYCHOL SERV JI Psychol. Serv. PD NOV PY 2013 VL 10 IS 4 BP 378 EP 385 DI 10.1037/a0032783 PG 8 WC Psychology, Clinical SC Psychology GA 254QZ UT WOS:000327182400003 PM 23855422 ER PT J AU Rohde, J Kagley, AN Fresh, KL Goetz, FA Quinn, TP AF Rohde, Jessica Kagley, Anna N. Fresh, Kurt L. Goetz, Fred A. Quinn, Thomas P. TI Partial Migration and Diel Movement Patterns in Puget Sound Coho Salmon SO TRANSACTIONS OF THE AMERICAN FISHERIES SOCIETY LA English DT Article ID JUVENILE SOCKEYE-SALMON; WIRE TAG RECOVERIES; CHINOOK SALMON; ONCORHYNCHUS-TSHAWYTSCHA; ANTIPREDATION WINDOW; BRITISH-COLUMBIA; OCEAN MIGRATION; MARINE SURVIVAL; PACIFIC SALMON; STRIPED BASS AB Partial migration, a term referring to populations in which only a fraction of the individuals migrate, is a widespread phenomenon among fishes. However, it is not always clear whether there are only two alternatives (migration or residency) or a continuum of movement patterns. For example, Coho Salmon Oncorhynchus kisutch are anadromous, and most individuals rear over the continental shelf or in offshore waters of the North Pacific Ocean; however, some Coho Salmon (known as residents) spend all or part of their marine lives within Puget Sound. The movements of residents are poorly documented, and it is unclear whether they ever leave Puget Sound and move to the coast of Washington and to what extent they move within Puget Sound. Accordingly, the goal of this study was to investigate the patterns of movement by immature Coho Salmon in Puget Sound at a series of spatial scales. We tagged 45 resident Coho Salmon in the central basin of Puget Sound with acoustic transmitters and detected their movements with fixed receivers in the Salish Sea. Seven individuals were detected as departing Puget Sound through the Strait of Juan de Fuca, but these fish did not differ in body size, origin (wild or hatchery), or tagging date from fish that remained in Puget Sound. The fish remaining as residents seldom moved between the marine basins of Puget Sound. Within the central basin, deeper/offshore sites had higher frequencies of detection and other indices of site use. Fish were more often present and moved more often at shallow sites close to shore during the night, whereas they were more often present and moved more at deep, offshore sites during the day. We suggest that rather than being a discrete behavior, residence in Puget Sound by Coho Salmon is part of a continuum of migratory behavior patterns. C1 [Rohde, Jessica; Goetz, Fred A.; Quinn, Thomas P.] Univ Washington, Sch Aquat & Fishery Sci, Seattle, WA 98195 USA. [Kagley, Anna N.; Fresh, Kurt L.] Natl Ocean & Atmospher Adm Fisheries, NW Fisheries Sci Ctr, Seattle, WA 98122 USA. [Goetz, Fred A.] US Army Corps Engineers, Seattle, WA 98134 USA. RP Rohde, J (reprint author), Univ Washington, Sch Aquat & Fishery Sci, Box 355020, Seattle, WA 98195 USA. EM rohdej@uw.edu FU State of Washington's Salmon Recovery Funding Board through the Washington Recreation and Conservation Office; NOAA Fisheries; H. Mason Keeler Endowment at the School of Aquatic and Fishery Sciences, University of Washington FX We thank the many agencies responsible for deployment and retrieval of receivers and for sharing their data with us, including but not limited to the National Oceanic and Atmospheric Administration (NOAA) Northwest Fisheries Science Center, the University of Washington's School of Aquatic and Fishery Sciences, the Washington Department of Fish and Wildlife, the U.S. Army Corps of Engineers, the Seattle Aquarium, Seattle City Light, the Nisqually and Squaxin Island tribal fisheries departments, and the Pacific Ocean Shelf Tracking Project. We thank Joshua Chamberlin for help in the field and with data analysis and interpretation and Jennifer Scheuerell and Dawn Spillsbury Pucci for help with database management. Genetic analysis to verify the species identification was conducted by David Kuligowski and David Teel (NOAA Fisheries). Funding for this project was provided by the State of Washington's Salmon Recovery Funding Board through the Washington Recreation and Conservation Office, NOAA Fisheries, and the H. Mason Keeler Endowment at the School of Aquatic and Fishery Sciences, University of Washington. NR 78 TC 3 Z9 3 U1 3 U2 11 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 520 CHESTNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA SN 0002-8487 EI 1548-8659 J9 T AM FISH SOC JI Trans. Am. Fish. Soc. PD NOV 1 PY 2013 VL 142 IS 6 BP 1615 EP 1628 DI 10.1080/00028487.2013.822421 PG 14 WC Fisheries SC Fisheries GA 258OX UT WOS:000327469700011 ER PT J AU Margolis, LM Pasiakos, SM AF Margolis, Lee M. Pasiakos, Stefan M. TI Optimizing Intramuscular Adaptations to Aerobic Exercise: Effects of Carbohydrate Restriction and Protein Supplementation on Mitochondrial Biogenesis SO ADVANCES IN NUTRITION LA English DT Review ID HUMAN SKELETAL-MUSCLE; GAMMA COACTIVATOR-1-ALPHA EXPRESSION; PGC-1-ALPHA MESSENGER-RNA; ENDURANCE EXERCISE; RESISTANCE EXERCISE; ENERGY-EXPENDITURE; ENZYME-ACTIVITY; P38 MAPK; ATHLETIC PERFORMANCE; BINDING-PROTEIN AB Mitochondrial biogenesis is a critical metabolic adaptation to aerobic exercise training that results in enhanced mitochondrial size, content, number, and activity. Recent evidence has shown that dietary manipulation can further enhance mitochondrial adaptations to aerobic exercise training, which may delay skeletal muscle fatigue and enhance exercise performance. Specifically, studies have demonstrated that combining carbohydrate restriction (endogenous and exogenous) with a single bout of aerobic exercise potentiates the beneficial effects of exercise on markers of mitochondrial biogenesis. Additionally, studies have demonstrated that high-quality protein supplementation enhances anabolic skeletal muscle intracellular signaling and mitochondrial protein synthesis following a single bout of aerobic exercise. Mitochondrial biogenesis is stimulated by complex intracellular signaling pathways that appear to be primarily regulated by 5'AMP-activated protein kinase and p38 mitogen-activated protein kinase mediated through proliferator-activated gamma receptor co-activator 1 alpha activation, resulting in increased mitochondrial DNA expression and enhanced skeletal muscle oxidative capacity. However, the mechanisms by which concomitant carbohydrate restriction and dietary protein supplementation modulates mitochondrial adaptations to aerobic exercise training remains unclear. This review summarizes intracellular regulation of mitochondrial biogenesis and the effects of carbohydrate restriction and protein supplementation on mitochondrial adaptations to aerobic exercise. C1 [Margolis, Lee M.; Pasiakos, Stefan M.] US Army Res Inst Environm Med, Mil Nutr Div, Natick, MA 01760 USA. RP Pasiakos, SM (reprint author), US Army Res Inst Environm Med, Mil Nutr Div, Natick, MA 01760 USA. EM stefan.pasiakos@us.army.mil RI Pasiakos, Stefan/E-6295-2014; OI Pasiakos, Stefan/0000-0002-5378-5820; , Lee/0000-0002-0652-1304 FU United States Army Military Research and Material Command FX Supported by United States Army Military Research and Material Command The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the Army or the Department of Defense. Any citations of commercial organizations and trade names in this report do not constitute an official Department of the Army endorsement of approval of the products or services of these organizations. NR 78 TC 5 Z9 5 U1 5 U2 24 PU AMER SOC NUTRITION-ASN PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 2161-8313 EI 2156-5376 J9 ADV NUTR JI Adv. Nutr. PD NOV PY 2013 VL 4 IS 6 BP 657 EP 664 DI 10.3945/an.113.004572 PG 8 WC Nutrition & Dietetics SC Nutrition & Dietetics GA 253TT UT WOS:000327112900006 PM 24228194 ER PT J AU Sivam, A Rochette, LM Smith, GA AF Sivam, Anita Rochette, Lynne M. Smith, Gary A. TI Stove-related injuries treated in EDs in the United States, 1990-2010 SO AMERICAN JOURNAL OF EMERGENCY MEDICINE LA English DT Article ID EPIDEMIOLOGIC APPROACH; BURN PREVENTION; CHILDREN AB Background: Household stoves are a common source of injury in the United States. Purpose: To investigate the epidemiology of stove-related injuries. Methods: The National Electronic Injury Surveillance System database was used to analyze cases of nonfatal stove-related injuries treated in US hospital emergency departments (EDs) from 1990 through 2010. Results: An estimated 910696 (95% CI, 789279-1032113) individuals were treated for stove-related injuries during the 21-year study period, yielding an average of 43366 injured persons annually or 5 injuries every hour. The number (m = -252.85; P = .033) and rate (m = -0.026; P < .001) of injured individuals significantly decreased during the study. Injuries were highest in 1991 (50656 cases; 2.0 per 10000) and lowest in 2005 (38669 cases; 1.31 per 10000), although there was an increase in 2010 (48990 cases; 1.58 per 10000). Patients = 19 years experienced 41.3% of stove-related injuries. The primarymechanism of injury was contact with stove parts (37.5%). The body region most commonly injured was the hand (44.6%), and a thermal burn was the most common diagnosis (51.8%). The majority (94.4%) of patients were treated and released from the ED. Patients > 60 years of age were 3.85 (95% CI, 2.97-4.98) times more likely to be admitted to the hospital than younger patients. Conclusions: This is the first comprehensive study of stove-related injuries in the United States using a nationally representative sample. Strategies to prevent stove-related injuries should address the multiple mechanisms of injury. (C) 2013 Elsevier Inc. All rights reserved. C1 [Sivam, Anita; Rochette, Lynne M.; Smith, Gary A.] Nationwide Childrens Hosp, Res Inst, Ctr Injury Res & Policy, Columbus, OH 43205 USA. [Sivam, Anita] Touro Coll Osteopath Med, New York, NY USA. [Rochette, Lynne M.] US Army Res Inst Behav & Social Sci, Ft Belvoir, VA USA. [Smith, Gary A.] Ohio State Univ, Coll Med, Dept Pediat, Columbus, OH 43210 USA. [Smith, Gary A.] Child Injury Prevent Alliance, Columbus, OH USA. RP Smith, GA (reprint author), Nationwide Childrens Hosp, Res Inst, Ctr Injury Res & Policy, Columbus, OH 43205 USA. EM gary.smith@nationwidechildrens.org FU National Center for Injury Prevention and Control at the Centers for Disease Control and Prevention [1H75CE001491] FX The authors gratefully acknowledge support from the National Center for Injury Prevention and Control at the Centers for Disease Control and Prevention (grant #1H75CE001491), which provided a student research stipend for author AS while she worked on this study. The interpretations and conclusions expressed in this article do not necessarily represent those of the funding agency, and shall not be construed as an official Department of the Army position, policy, or decision. NR 21 TC 3 Z9 3 U1 0 U2 0 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0735-6757 EI 1532-8171 J9 AM J EMERG MED JI Am. J. Emerg. Med. PD NOV PY 2013 VL 31 IS 11 BP 1571 EP 1577 DI 10.1016/j.ajem.2013.07.034 PG 7 WC Emergency Medicine SC Emergency Medicine GA 242WA UT WOS:000326274200007 PM 24041643 ER PT J AU Morgan, T DeLorenzo, R Ward, J White, C Husaini, S Kragh, J Dawson, P AF Morgan, T. DeLorenzo, R. Ward, J. White, C. Husaini, S. Kragh, J. Dawson, P. TI Perfused Cadavers as a Training Model for Invasive Lifesaving Procedures SO ANNALS OF EMERGENCY MEDICINE LA English DT Meeting Abstract CT CORD Academic Assembly CY MAR 05-09, 2013 CL Denver, CO SP Council Emergency Med Residency Directors C1 San Antonio Mil Med Ctr, San Antonio, TX USA. US Army, Inst Surg Res, Ft Sam Houston, TX 78234 USA. NR 0 TC 1 Z9 1 U1 0 U2 0 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0196-0644 J9 ANN EMERG MED JI Ann. Emerg. Med. PD NOV PY 2013 VL 62 IS 5 MA 43 BP S180 EP S180 PG 1 WC Emergency Medicine SC Emergency Medicine GA 251CU UT WOS:000326906200073 ER PT J AU Ryan, TA Kohl, AN Soucek, DJ Smith, TS Brandt, TM Bonner, TH Cropek, DM AF Ryan, T. A. Kohl, A. N. Soucek, D. J. Smith, T. S. Brandt, T. M. Bonner, T. H. Cropek, D. M. TI Short-Term Effects of Military Fog Oil on the Fountain Darter (Etheostoma fonticola) SO ARCHIVES OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY LA English DT Article ID SLOPE CRUDE-OIL; PHOTOENHANCED TOXICITY; WEATHERED OIL; PHOTOTOXICITY; FRACTIONS AB Toxicity tests evaluated chronic and sublethal effects of fog oil (FO) on a freshwater endangered fish. FO is released during military training as an obscurant smoke that can drift into aquatic habitats. Fountain darters, Etheostoma fonticola, of four distinct life stages were exposed under laboratory conditions to three forms of FO. FO was vaporized into smoke and allowed to settle onto water, violently agitated with water, and dosed onto water followed by photo-oxidization by ultraviolet irradiation. Single smoke exposures of spawning adult fish did not affect egg production, egg viability, or adult fish survival in 21-day tests. Multiple daily smoke exposures induced mortality after 5 days for larvae fish. Larvae and juvenile fish were more sensitive than eggs in 96-h lethal concentration (LC50) tests with FO-water mixtures and photo-oxidized FO. Water-soluble FO components photo-modified by ultraviolet radiation were the most toxic, thus indicating the value of examining weathering and aging of chemicals for the best determination of environmental impact. C1 [Ryan, T. A.; Kohl, A. N.; Smith, T. S.; Cropek, D. M.] US Army, CERL, Corps Engineers, Champaign, IL 61822 USA. [Soucek, D. J.] Illinois Nat Hist Survey, Champaign, IL 61820 USA. [Brandt, T. M.] US Fish & Wildlife Serv, Aquat Resources Ctr, San Marcos, TX 78666 USA. [Bonner, T. H.] SW Texas State Univ, Dept Biol, Aquat Biol Program, San Marcos, TX 78666 USA. RP Cropek, DM (reprint author), US Army, CERL, Corps Engineers, 2902 Newmark Dr, Champaign, IL 61822 USA. EM donald.m.cropek@usace.army.mil NR 31 TC 0 Z9 0 U1 0 U2 9 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0090-4341 EI 1432-0703 J9 ARCH ENVIRON CON TOX JI Arch. Environ. Contam. Toxicol. PD NOV PY 2013 VL 65 IS 4 BP 790 EP 797 DI 10.1007/s00244-013-9958-5 PG 8 WC Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA 253PN UT WOS:000327101700017 PM 24121718 ER PT J AU McMichael, IT Nallon, EC Schnee, VP Scott, WR Mirotznik, MS AF McMichael, Ian T. Nallon, Eric C. Schnee, Vincent P. Scott, Waymond R., Jr. Mirotznik, Mark S. TI EBG Antenna for GPR Colocated With a Metal Detector for Landmine Detection SO IEEE GEOSCIENCE AND REMOTE SENSING LETTERS LA English DT Article DE Dual sensor; electromagnetic band-gap (EBG) antenna; ground-penetrating radar (GPR); landmine detection; metal detector ID MINE DETECTION; SYSTEM; MODELS; RADAR AB Electromagnetic band-gap (EBG) antennas are ideal for handheld sensing applications, such as ground-penetrating radar (GPR) for landmine detection, because of their small size, efficiency, and directivity. Increased detection performance has been shown when a GPR is combined with a metal detector, but a typical EBG antenna would preclude the sensors from being colocated because of the large amount of metal in the EBG structure. An EBG composed of very thin metal is proposed in this letter for application as a GPR colocated with a metal detector, without causing a significant self-response in the metal detector. Manufacturing methods are discussed, and GPR measurements are shown from the thin-metal EBG antennas. The metal detector response from a thin metal sheet is discussed, and measurements of the EBG ground planes are shown using a laboratory wideband electromagnetic induction system. The response from the thin metal is shown to be as low as three orders of magnitude less than from a copper sheet at typical metal detector frequencies. C1 [McMichael, Ian T.] Univ Delaware, Newark, DE 19716 USA. [McMichael, Ian T.; Nallon, Eric C.; Schnee, Vincent P.] US Army Commun Elect Res, Night Vis & Elect Sensor Directorate, Res Dev & Engn Command, Ft Belvoir, VA 22060 USA. [Scott, Waymond R., Jr.] Georgia Inst Technol, Sch Elect & Comp Engn, Atlanta, GA 30332 USA. [Mirotznik, Mark S.] Univ Delaware, Dept Elect & Comp Engn, Newark, DE 19716 USA. RP McMichael, IT (reprint author), Univ Delaware, Newark, DE 19716 USA. NR 16 TC 1 Z9 1 U1 2 U2 15 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1545-598X EI 1558-0571 J9 IEEE GEOSCI REMOTE S JI IEEE Geosci. Remote Sens. Lett. PD NOV PY 2013 VL 10 IS 6 BP 1329 EP 1333 DI 10.1109/LGRS.2013.2239604 PG 5 WC Geochemistry & Geophysics; Engineering, Electrical & Electronic; Remote Sensing; Imaging Science & Photographic Technology SC Geochemistry & Geophysics; Engineering; Remote Sensing; Imaging Science & Photographic Technology GA 251XI UT WOS:000326966700012 ER PT J AU Grujicic, M Yavari, R Ramaswami, S Snipes, JS Yen, CF Cheeseman, BA AF Grujicic, M. Yavari, R. Ramaswami, S. Snipes, J. S. Yen, C. -F. Cheeseman, B. A. TI Molecular-Level Study of the Effect of Prior Axial Compression/Torsion on the Axial-Tensile Strength of PPTA Fibers SO JOURNAL OF MATERIALS ENGINEERING AND PERFORMANCE LA English DT Article DE effect of compression and torsion; Kevlar; PPTA; tensile properties ID MECHANICAL-PROPERTIES; ARAMID FIBERS; FORCE-FIELD; MODEL; PERFORMANCE; COMPOSITES; BEHAVIOR; COMPASS AB A comprehensive all-atom molecular-level computational investigation is carried out in order to identify and quantify: (i) the effect of prior longitudinal-compressive or axial-torsional loading on the longitudinal-tensile behavior of p-phenylene terephthalamide (PPTA) fibrils/fibers; and (ii) the role various microstructural/topological defects play in affecting this behavior. Experimental and computational results available in the relevant open literature were utilized to construct various defects within the molecular-level model and to assign the concentration to these defects consistent with the values generally encountered under "prototypical" PPTA-polymer synthesis and fiber fabrication conditions. When quantifying the effect of the prior longitudinal-compressive/axial-torsional loading on the longitudinal-tensile behavior of PPTA fibrils, the stochastic nature of the size/potency of these defects was taken into account. The results obtained revealed that: (a) due to the stochastic nature of the defect type, concentration/number density and size/potency, the PPTA fibril/fiber longitudinal-tensile strength is a statistical quantity possessing a characteristic probability density function; (b) application of the prior axial compression or axial torsion to the PPTA imperfect single-crystalline fibrils degrades their longitudinal-tensile strength and only slightly modifies the associated probability density function; and (c) introduction of the fibril/fiber interfaces into the computational analyses showed that prior axial torsion can induce major changes in the material microstructure, causing significant reductions in the PPTA-fiber longitudinal-tensile strength and appreciable changes in the associated probability density function. C1 [Grujicic, M.; Yavari, R.; Ramaswami, S.; Snipes, J. S.] Clemson Univ, Dept Mech Engn, Clemson, SC 29634 USA. [Yen, C. -F.; Cheeseman, B. A.] Army Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. RP Grujicic, M (reprint author), Clemson Univ, Dept Mech Engn, 241 Engn Innovat Bldg, Clemson, SC 29634 USA. EM gmica@clemson.edu FU Army Research Office (ARO) [W911NF-09-1-0513] FX The material presented in this paper is based on work supported by the Army Research Office (ARO) research contract entitled "Multi-length Scale Material Model Development for Armor-grade Composites", Contract Number W911NF-09-1-0513. The authors are indebted to Dr. Larry Russell of ARO for his continuing support and interest in the present work. NR 30 TC 7 Z9 7 U1 3 U2 31 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1059-9495 EI 1544-1024 J9 J MATER ENG PERFORM JI J. Mater. Eng. Perform. PD NOV PY 2013 VL 22 IS 11 BP 3269 EP 3287 DI 10.1007/s11665-013-0648-2 PG 19 WC Materials Science, Multidisciplinary SC Materials Science GA 250WX UT WOS:000326888500010 ER PT J AU Kelly, GS Advani, SG Gillespie, JW Bogetti, TA AF Kelly, Gregory S. Advani, Suresh G. Gillespie, John W., Jr. Bogetti, Travis A. TI A model to characterize acoustic softening during ultrasonic consolidation SO JOURNAL OF MATERIALS PROCESSING TECHNOLOGY LA English DT Article DE Ultrasonic consolidation; Acoustic softening; Thermo-mechanical analysis; Aluminum ID TOW-PLACEMENT PROCESS; PROCESS PARAMETERS; BOND FORMATION; ALUMINUM; TEMPERATURE; VIBRATION; STRENGTH; STRESS; METALS AB Ultrasonic consolidation (UC) is a solid state bonding process in which thin metal foils are bonded under the influence of ultrasonic vibration and pressure. Large parts can be made by placing foils side by side or by stacking layers to create thicker parts. Thermal and acoustic softening of metals during UC leads to increased plastic deformation and plays an important role in bond formation. In this work, a thermo-mechanical finite element model is developed to quantify the degree of thermal and acoustic softening occurring in Al 1100-0 foils during UC. The model uses experimentally measured temperatures and changes in the foil's geometry during UC to quantify the amount of thermal and acoustic softening. Acoustic softening is shown to reduce the yield stress of Al 1100-0 foils by up to 82%. In addition, thermal softening is found to be relatively minor, typically less than 5% of the total material softening. This method to quantify acoustic softening during UC allows for a better overall understanding of the bonding process and allows several aspects of the UC bonding process to be optimized and improved. (C) 2013 Elsevier B.V. All rights reserved. C1 [Kelly, Gregory S.; Advani, Suresh G.; Gillespie, John W., Jr.] Univ Delaware, Ctr Composite Mat, Newark, DE 19716 USA. [Bogetti, Travis A.] Army Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Advani, SG (reprint author), Univ Delaware, Ctr Composite Mat, Newark, DE 19716 USA. EM advani@udel.edu FU Army Research Laboratory [W911NF-06-2-011] FX Research was sponsored by the Army Research Laboratory and was accomplished under Cooperative Agreement Number W911NF-06-2-011. The views and conclusions contained in this document are those of the authors and should not be interpreted as representing the official policies, either expressed or implied, of the Army Research Laboratory or the U.S. Government. The U.S. Government is authorized to reproduce and distribute reprints for Government purposes notwithstanding any copyright notation heron. NR 32 TC 16 Z9 17 U1 0 U2 17 PU ELSEVIER SCIENCE SA PI LAUSANNE PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND SN 0924-0136 J9 J MATER PROCESS TECH JI J. Mater. Process. Technol. PD NOV PY 2013 VL 213 IS 11 BP 1835 EP 1845 DI 10.1016/j.jmatprotec.2013.05.008 PG 11 WC Engineering, Industrial; Engineering, Manufacturing; Materials Science, Multidisciplinary SC Engineering; Materials Science GA 252IB UT WOS:000326997300004 ER PT J AU Feng, XR Sambanthamoorthy, K Palys, T Paranavitana, C AF Feng, Xiaorong Sambanthamoorthy, Karthik Palys, Thomas Paranavitana, Chrysanthi TI The human antimicrobial peptide LL-37 and its fragments possess both antimicrobial and antibiofilm activities against multidrug-resistant Acinetobacter baumannii SO PEPTIDES LA English DT Article DE Cathelicidin; Biofilm; Acinetobacter baumannii; Anti-infective ID HUMAN CATHELICIDIN LL-37; BACTERIAL BIOFILM FORMATION; STAPHYLOCOCCUS-AUREUS; IDENTIFICATION; INFECTION; DEFENSE; OPERATIONS; INHIBIT; BINDING; PROTEIN AB Acinetobacter baumannii infections are difficult to treat due to multidrug resistance. Biofilm formation by A. baumannii is an additional factor in its ability to resist antimicrobial therapy. The antibacterial and antibiofilm activities of the human antimicrobial peptide LL-37 and its fragments KS-30, KR-20 and KR-12 against clinical isolates of multidrug-resistant (MDR) A. baumannii were evaluated. The minimal inhibitory concentration (MIC) of LL-37 against MDR A. baumannii isolates ranged from 16 to 32 mu g/mL. The MIC of KS-30 fragment varied from 8.0 to16 mu g/mL and the KR-20 fragment MIC ranged from 16 to 64 mu g/mL. LL-37 and KS-30 fragment exhibited 100% bactericidal activity against five A. baumannii strains, including four MDR clinical isolates, within 30 min at concentrations of 0.25-1 mu g/mL. By 0.5h, the fragments KR-20 and KR-12 eliminated all tested strains at 8 and 64 mu g/mL respectively. LL-37 and its fragments displayed anti-adherence activities between 32-128 mu g/mL. A minimum biofilm eradication concentration (MBEC) biofilm assay demonstrated that LL-37 inhibited and dispersed A. baumannii biofilms at 32 mu g/mL respectively. Truncated fragments of LL-37 inhibited biofilms at concentrations of 64-128 mu g/mL. KS-30, the truncated variant of LL-37, effectively dispersed biofilms at 64 mu g/mL. At 24 h, no detectable toxicity was observed at the efficacious doses when cytotoxicity assays were performed. Thus, LL-37, KS-30 and KR-20 exhibit significant antimicrobial activity against MDR A. baumannii. The prevention of biofilm formation in vitro by LL-37, KS-30 and KR-20 adds significance to their efficacy. These peptides can be potential therapeutics against MDR A. baumannii infections. (C) 2013 Elsevier Inc. All rights reserved. C1 [Feng, Xiaorong; Sambanthamoorthy, Karthik; Palys, Thomas; Paranavitana, Chrysanthi] Walter Reed Army Inst Res, Bacterial Dis Branch, Dept Wound Infect, Silver Spring, MD 20910 USA. RP Paranavitana, C (reprint author), Walter Reed Army Inst Res, Bacterial Dis Branch, Dept Wound Infect, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM chrysanthi.m.paranavitana2.ctr@us.army.mil RI feng, xiaorong/G-4811-2010 OI feng, xiaorong/0000-0001-8410-3020 FU Military Infectious Diseases Research Program (MIDRP) FX The findings and opinions expressed herein belong to the authors and do not necessarily reflect the official views of the WRAIR, the U.S. Army, or the Department of Defense. This work was supported by a Military Infectious Diseases Research Program (MIDRP) grant awarded to Dr. C. P. The authors would like to thank Dr. Daniel Zurawski and Mr. Mitchell Thompson at WRAIR for providing comments and suggestions when necessary and Ms. Amy Michels for editing the manuscript. NR 42 TC 26 Z9 27 U1 1 U2 20 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0196-9781 EI 1873-5169 J9 PEPTIDES JI Peptides PD NOV PY 2013 VL 49 BP 131 EP 137 DI 10.1016/j.peptides.2013.09.007 PG 7 WC Biochemistry & Molecular Biology; Endocrinology & Metabolism; Pharmacology & Pharmacy SC Biochemistry & Molecular Biology; Endocrinology & Metabolism; Pharmacology & Pharmacy GA 251PA UT WOS:000326941100018 PM 24071034 ER PT J AU Cho, JH Chen, IR AF Cho, Jin-Hee Chen, Ing-Ray TI On the tradeoff between altruism and selfishness in MANET trust management SO AD HOC NETWORKS LA English DT Article DE Altruism; Selfishness; Demand and pricing theory; Mobile ad hoc networks; Trust management ID AD-HOC NETWORKS; NODES; COOPERATION; REPUTATION; DEMAND AB Mobile ad hoc and sensor networks may consist of a mixture of nodes, some of which may be considered selfish due to a lack of cooperativeness in providing network services such as forwarding packets. In the literature, existing trust management protocols for mobile ad hoc networks advocate isolating selfish nodes as soon as they are detected. Further, altruistic behaviors are encouraged with incentive mechanisms. In this paper, we propose and analyze a trust management protocol for group communication systems where selfish nodes exist and system survivability is highly critical to mission execution. Rather than always encouraging altruistic behaviors, we consider the tradeoff between a node's individual welfare (e.g., saving energy to prolong the node lifetime) vs. global welfare (e.g., achieving a given mission with sufficient service availability) and identify the best design condition of this behavior model to balance selfish vs. altruistic behaviors. With the system lifetime and the mission success probability as our trust-based reliability metric, we show that our behavior model that exploits the tradeoff between selfishness vs. altruism outperforms one that only encourages altruistic behaviors. Published by Elsevier B.V. C1 [Cho, Jin-Hee] USARL, CISD, Adelphi, MD 20783 USA. [Chen, Ing-Ray] Virginia Tech, Dept Comp Sci, Falls Church, VA 22043 USA. RP Cho, JH (reprint author), USARL, CISD, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM jinhee.cho@us.army.mil; irchen@vt.edu FU U. S. Army Research Laboratory; U. S. Army Research Office [W911NF-12-1-0445]; Department of Defense (DoD) through the office of the Assistant Secretary of Defense for Research and Engineering (ASD (RE)) FX This material is based upon work supported in part by the U. S. Army Research Laboratory and the U. S. Army Research Office under Contract number W911NF-12-1-0445. This research was also partially supported by the Department of Defense (DoD) through the office of the Assistant Secretary of Defense for Research and Engineering (ASD (R&E)). The views and opinions of the author(s) do not reflect those of the DoD nor ASD (R&E). NR 51 TC 8 Z9 8 U1 1 U2 8 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1570-8705 EI 1570-8713 J9 AD HOC NETW JI Ad Hoc Netw. PD NOV PY 2013 VL 11 IS 8 SI SI BP 2217 EP 2234 DI 10.1016/j.adhoc.2013.05.004 PG 18 WC Computer Science, Information Systems; Telecommunications SC Computer Science; Telecommunications GA 247YW UT WOS:000326661900005 ER PT J AU Biedenkapp, JC Leon, LR AF Biedenkapp, Joseph C. Leon, Lisa R. TI Increased cytokine and chemokine gene expression in the CNS of mice during heat stroke recovery SO AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY LA English DT Article DE heat stroke; cytokines; chemokines; hypothermia; fever; systemic inflammatory response ID INDUCED SICKNESS BEHAVIOR; CENTRAL-NERVOUS-SYSTEM; STRESS; FEVER; HEATSTROKE; BRAIN; RATS; INTERLEUKIN-1-BETA; INFLAMMATION; MICROGLIA AB Heat stroke (HS) is characterized by a systemic inflammatory response syndrome (SIRS) consisting of profound core temperature (T-c) changes in mice. Encephalopathy is common at HS collapse, but inflammatory changes occurring in the brain during the SIRS remain unidentified. We determined the association between inflammatory gene expression changes in the brain with T-c disturbances during HS recovery in mice. Gene expression changes of heat shock protein (HSP)72, heme oxygenase (hmox1), cytokines (IL-1 beta , IL-6, TNF-alpha), cyclooxygenase enzymes (COX-1, COX-2), chemokines (MCP-1, MIP-1 alpha , MIP-1 beta , CX(3)CR1), and glia activation markers (CD14, aif1, vimentin) were examined in the hypothalamus (HY) and hippocampus (HC) of control (T-c similar to 36.0 degrees C) and HS mice at T-c,T-Max (42.7 degrees C), hypothermia depth (HD; 29.3 +/- 0.4 degrees C), and fever (37.8 +/- 0.3 degrees C). HSP72 (HY < HC) and IL-1 beta (HY only) were the only genes that showed increased expression at T-c,T-Max. HSP72 (HY < HC), hmox1 (HY < HC), cytokine (HY < HC), and chemokine (HY = HC) expression was highest at HD and similar to controls during fever. COX-1 expression was unaffected by HS, whereas HD was associated with approximately threefold increase in COX-2 expression (HY only). COX-2 expression was not increased during fever and indomethacin (COX inhibitor) had no effect on this T-c response indicating fever is regulated by other inflammatory pathways. CD14, aif1, and vimentin activation at HD coincided with maximal cytokine and chemokine expression suggesting glia cells are a possible source of brain cytokines and chemokines during HS recovery. The inflammatory gene expression changes during HS recovery suggest cytokines and/or chemokines may be initiating development or rewarming from hypothermia, whereas fever pathway(s) remain to be elucidated. C1 [Biedenkapp, Joseph C.] US Army Res Inst Environm Med, Mil Nutr Div, Natick, MA 01760 USA. [Leon, Lisa R.] US Army Res Inst Environm Med, Thermal & Mt Med Div, Natick, MA 01760 USA. RP Leon, LR (reprint author), US Army Res Inst Environm Med, Thermal & Mt Med Div, Kansas St,Bldg 42, Natick, MA 01760 USA. EM lisa.r.leon.civ@mail.mil OI Biedenkapp, Joseph/0000-0001-9574-3752 FU United States Army Medical Research and Material Command FX This research was funded by United States Army Medical Research and Material Command. This article has been approved for public release. Distribution of this article is unlimited. NR 33 TC 5 Z9 5 U1 1 U2 12 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 0363-6119 EI 1522-1490 J9 AM J PHYSIOL-REG I JI Am. J. Physiol.-Regul. Integr. Comp. Physiol. PD NOV PY 2013 VL 305 IS 9 BP R978 EP R986 DI 10.1152/ajpregu.00011.2013 PG 9 WC Physiology SC Physiology GA 247AI UT WOS:000326584200002 PM 24026076 ER PT J AU Owens, BD Campbell, SE Cameron, KL AF Owens, Brett D. Campbell, Scot E. Cameron, Kenneth L. TI Risk Factors for Posterior Shoulder Instability in Young Athletes SO AMERICAN JOURNAL OF SPORTS MEDICINE LA English DT Article DE shoulder instability; posterior instability; glenoid retroversion; injury prevention ID SUBLUXATION; HISTORY; REPAIR AB Background: While posterior glenohumeral instability is becoming increasingly common among young athletes, little is known of the risk factors for injury. Purpose: To determine the modifiable and nonmodifiable risk factors for posterior shoulder instability in a high-risk cohort. Study Design: Case-control study (prognosis); Level of evidence, 2. Methods: A prospective cohort study in which 714 young athletes were followed from June 2006 through May 2010 was conducted. Baseline testing included a subjective history of instability, instability testing by a sports medicine fellowship-trained orthopaedic surgeon, range of motion, strength measurement with a handheld dynamometer, and bilateral noncontrast magnetic resonance imaging of the shoulder. A musculoskeletal radiologist measured glenoid version, height, depth, rotator interval (RI) height, RI width, RI area, and RI index. Participants were followed to document all acute posterior shoulder instability events during the 4-year follow-up period. The time to the posterior shoulder instability event during the follow-up period was the primary outcome of interest. Univariate and multivariable Cox proportional hazards regression models were used to analyze the data. Results: Complete data on 714 participants were obtained. During the 4-year surveillance period, 46 shoulders sustained documented glenohumeral instability events, of which only 7 were posterior in direction. The baseline factors that were associated with subsequent posterior instability during follow-up were increased glenoid retroversion (P < .0001), increased external rotation strength in adduction (P = .029) and at 45 degrees of abduction (P = .015), and increased internal rotation strength in adduction (P = .038). Conclusion: This is the largest known prospective study to follow healthy participants in the development of posterior shoulder instability. Posterior instability represents 10% of all instability events. The most significant risk factor was increased glenoid retroversion. While increased internal/external strength was also associated with subsequent instability, it is unclear whether these strength differences are causative or reactive to the difference in glenoid anatomy. This work confirms that increased glenoid retroversion is a significant prospective risk factor for posterior instability. C1 [Owens, Brett D.; Campbell, Scot E.; Cameron, Kenneth L.] US Mil Acad, Keller Army Hosp, West Point, NY 10996 USA. RP Owens, BD (reprint author), US Mil Acad, Keller Army Hosp, 900 Washington Rd, West Point, NY 10996 USA. EM b.owens@us.army.mil OI Cameron, Kenneth/0000-0002-6276-4482 FU Prospective Research Grant from the Orthopaedic Research and Education Foundation; American Journal of Sports Medicine FX One or more of the authors has declared the following potential conflict of interest or source of funding: This study was supported by a Prospective Research Grant from the Orthopaedic Research and Education Foundation. B.D.O. and K. L. C. receive institutional research support from OREF, NATA, NIAMS, CDMRP, and Histogenics. B.D.O. receives a salary from The American Journal of Sports Medicine, serves as a consultant for the Musculoskeletal Transplant Foundation and Johnson & Johnson (Mitek), and donates book royalties (SLACK) to a fellowship education fund. NR 19 TC 18 Z9 18 U1 1 U2 8 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0363-5465 EI 1552-3365 J9 AM J SPORT MED JI Am. J. Sports Med. PD NOV PY 2013 VL 41 IS 11 BP 2645 EP 2649 DI 10.1177/0363546513501508 PG 5 WC Orthopedics; Sport Sciences SC Orthopedics; Sport Sciences GA 245HI UT WOS:000326453500028 PM 23982394 ER PT J AU Hoyt, N Brunell, M Kroeck, K Hable, M Crouse, L O'Neill, A Bannon, DI AF Hoyt, Nathan Brunell, Marla Kroeck, Karl Hable, Mike Crouse, Lee O'Neill, Art Bannon, Desmond I. TI Biomarkers of oral exposure to 3-nitro-1,2,4-triazol-5-one (NTO) and 2,4-dinitroanisole (DNAN) in blood and urine of rhesus macaques (Macaca mulatta) SO BIOMARKERS LA English DT Article DE 2,4-dinitroanisole; 2,4-dinitrophenol; 3-nitro-1,2,4-triazol-5-one; insensitive munitions; rhesus ID 2,4-DINITROPHENOL; METABOLISM AB The U.S. Department of Defense is using the chemicals 2,4-dinitroanisole (DNAN) and 3-nitro-1, 2,4-triazol-5-one (NTO) in new munitions development. In a screen for biomarkers of exposure, these compounds were measured in urine and blood of male rhesus monkeys after oral doses. NTO peaked at 4h, with urinary concentrations at least 100-fold higher than that of blood or serum while 4-dinitrophenol (DNP), a metabolite of DNAN, appeared in blood at concentrations 10- to 20-fold higher than the parent compound. For human exposure monitoring, urine is optimal for NTO while the metabolite DNP in blood is best for DNAN. C1 [Hoyt, Nathan; Brunell, Marla] Naval Med Res Ctr, Walter Reed Army Inst Res, Vet Serv Program, Silver Spring, MD USA. [Kroeck, Karl; Hable, Mike; Crouse, Lee; O'Neill, Art; Bannon, Desmond I.] US Army Publ Hlth Command, Army Inst Publ Hlth, Aberdeen Proving Ground, MD 21010 USA. RP Bannon, DI (reprint author), US Army Publ Hlth Command, Inst Publ Hlth, Bldg E2100 Toxicol Portfolio, Aberdeen Proving Ground, MD 21010 USA. EM desmond.i.bannon.civ@mail.mil FU U.S. Army Public Health Command; US Army Institute of Public Health FX This work was performed at Walter Reed Army Institute of Research, Naval Medical Research Center, Silver Spring, MD, USA 20912-7500, and was funded by the US Army Institute of Public Health under an MOU. There is no objection to its presentation or publication. The opinions and assertions contained herein are the private ones of the authors and are not to be construed as such or reflecting the views of the Department of Defense. Research was conducted in compliance with the Animal Welfare Act and other federal statutes and regulations relating to animals and experiments involving animals and adheres to principles stated in the Guide for the Care and Use of Laboratory Animals, NRC Publication, 2011 edition. All authors report no conflict of interest. This work was funded by U.S. Army Public Health Command. NR 23 TC 13 Z9 13 U1 1 U2 14 PU INFORMA HEALTHCARE PI LONDON PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND SN 1354-750X EI 1366-5804 J9 BIOMARKERS JI Biomarkers PD NOV PY 2013 VL 18 IS 7 BP 587 EP 594 DI 10.3109/1354750X.2013.829522 PG 8 WC Biotechnology & Applied Microbiology; Toxicology SC Biotechnology & Applied Microbiology; Toxicology GA 251EF UT WOS:000326909900006 PM 24001308 ER PT J AU Sabatini, JJ Moretti, JD Hall, DR Robert, LL AF Sabatini, Jesse J. Moretti, Jared D. Hall, Derrick R. Robert, Leon L., Jr. TI Recover, Recycle, and Reuse: Prove-Out of Pyrotechnic Illuminants Containing Demilitarized Magnesium SO CHEMPLUSCHEM LA English DT Article DE green chemistry; illuminants; magnesium; pyrotechnics; sustainable chemistry ID PERCHLORATE-FREE; CIVILIAN APPLICATIONS; LIGHT ILLUMINANTS; MILITARY AB The development and prove-out of yellow-light-emitting pyrotechnic illuminants based on recover, recycle, and reuse (R-3) technology is described. Magnesium used in this investigation was recovered from four different illuminating pyrotechnic munitions by means of an environmentally friendly demilitarization process. Despite significant differences in the particle size and purity between the four lots of recovered magnesium, the performance of each loton evaluation in the M127A1 US Army yellow-light-emitting illuminant configurationexceeded the military requirement and performance of the virgin magnesium-containing control. All formulations were found to have low sensitivities to various ignition stimuli and possessed high thermal onset temperatures. In addition to the military significance, this demonstrated green pyrotechnics technology of using recycled magnesium in illuminating pyrotechnics may also be of interest to the civilian fireworks community. C1 [Sabatini, Jesse J.; Moretti, Jared D.] US Army RDECOM ARDEC, Pyrotech Technol Prototyping Div, Picatinny Arsenal, NJ 07806 USA. [Hall, Derrick R.; Robert, Leon L., Jr.] US Mil Acad, Dept Chem & Life Sci, West Point, NY 10996 USA. RP Sabatini, JJ (reprint author), US Army RDECOM ARDEC, Pyrotech Technol Prototyping Div, Picatinny Arsenal, NJ 07806 USA. EM jesse.j.sabatini.civ@mail.mil FU US Army (Picatinny Arsenal, NJ); United States Military Academy, Department of Chemistry Life Sciences FX We are indebted to the US Army (Picatinny Arsenal, NJ) for funding of this work. We wish to recognize the United States Military Academy, Department of Chemistry & Life Sciences for sponsoring the Academic Individual Advanced Development (AIAD) Program. Dr. Sara K. Pliskin (NSWC/CRANE) and Dan Burch (SAIC) are gratefully acknowledged for their discussions concerning the demilitarization process. We wish to recognize Dr. David R. Dillehay (Expal USA) and David Turner (Expal USA) for their advice concerning epoxy-polysulfide binder systems in obsolete illuminants. We thank Jessica Vanatta for performing particle size analysis and Henry A. Grau for obtaining DSC thermal onset data. Dr. Jay C. Poret is acknowledged for his assistance in setting up the light detector and spectrometer prior to tunnel testing. NR 18 TC 0 Z9 0 U1 1 U2 4 PU WILEY-V C H VERLAG GMBH PI WEINHEIM PA BOSCHSTRASSE 12, D-69469 WEINHEIM, GERMANY SN 2192-6506 J9 CHEMPLUSCHEM JI ChemPlusChem PD NOV PY 2013 VL 78 IS 11 BP 1358 EP 1362 DI 10.1002/cplu.201300231 PG 5 WC Chemistry, Multidisciplinary SC Chemistry GA 251AQ UT WOS:000326900600011 ER PT J AU Alberts, WCK Sanchez, KJ AF Alberts, W. C. Kirkpatrick, II Sanchez, Kevin J. TI Deduction of the acoustic impedance of the ground via a simulated three-dimensional microphone array SO JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA LA English DT Article AB While commonly used ground impedance deduction methods often utilize pairs of vertically separated microphones, deployed arrays rarely have this configuration, which increases the difficulty in automatically deducing local ground impedance from these arrays. The ability to deduce ground impedance using random sounds incident on a three-dimensional array would increase, for example, the accuracy of estimated elevation angles. The methods described by the American National Standards Institute Method for Determining the Acoustic Impedance of Ground Surfaces are extended to simulate deducing ground impedance by a three-dimensional array. Ground parameters indicative of grassland are successfully determined using a simulated three-dimensional array. C1 [Alberts, W. C. Kirkpatrick, II; Sanchez, Kevin J.] US Army Res Lab, Attn RDRL SES P, Adelphi, MD 20783 USA. RP Alberts, WCK (reprint author), US Army Res Lab, Attn RDRL SES P, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM william.c.alberts4.civ@mail.mil; kjsanche@ucsd.edu NR 10 TC 1 Z9 1 U1 0 U2 2 PU ACOUSTICAL SOC AMER AMER INST PHYSICS PI MELVILLE PA STE 1 NO 1, 2 HUNTINGTON QUADRANGLE, MELVILLE, NY 11747-4502 USA SN 0001-4966 EI 1520-8524 J9 J ACOUST SOC AM JI J. Acoust. Soc. Am. PD NOV PY 2013 VL 134 IS 5 BP EL471 EP EL476 DI 10.1121/1.4826149 PN 1 PG 6 WC Acoustics; Audiology & Speech-Language Pathology SC Acoustics; Audiology & Speech-Language Pathology GA 247SO UT WOS:000326640800015 PM 24181993 ER PT J AU Burgess, EB Heilbrun, M AF Burgess, Edwin B. Heilbrun, Margaret TI Collection Development vertical bar World War vertical bar SO LIBRARY JOURNAL LA English DT Article C1 [Burgess, Edwin B.] Combined Arms Res Lib, Ft Leavenworth, KS USA. RP Burgess, EB (reprint author), Combined Arms Res Lib, Ft Leavenworth, KS USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU REED BUSINESS INFORMATION PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010 USA SN 0363-0277 J9 LIBR J JI Libr. J. PD NOV 1 PY 2013 VL 138 IS 18 BP 52 EP 52 PG 1 WC Information Science & Library Science SC Information Science & Library Science GA 247HK UT WOS:000326608300020 ER PT J AU Stephenson, LD Heffron, A Mehnert, B Lawrence, D AF Stephenson, L. D. Heffron, Andrew Mehnert, Brenda Lawrence, Debbie TI Laboratory Testing Predicts Long-Term Degradation of Insulating Materials SO MATERIALS PERFORMANCE LA English DT Article AB Advanced insulation materials used in building envelopes to mitigate energy losses are subject to environmental aging, which may degrade their performance over time. Experiments are being conducted to develop a methodology to predict durability of insulation materials and determine R-value degradation over service life. C1 [Stephenson, L. D.] US Army, Construct Engn Res Lab, Engn Res & Dev Ctr, Champaign, IL 61826 USA. [Heffron, Andrew] US Army, ERDC CERL, Champaign, IL 61826 USA. [Heffron, Andrew] Univ Illinois, Urbana, IL 61801 USA. [Mehnert, Brenda] PERTAN Grp, Champaign, IL 61820 USA. RP Stephenson, LD (reprint author), US Army, Construct Engn Res Lab, Engn Res & Dev Ctr, POB 9005, Champaign, IL 61826 USA. EM Larry.D.Stephenson@usace.army.mil; Debbie.J.Lawrence@usace.army.mil NR 5 TC 0 Z9 0 U1 0 U2 3 PU NATL ASSOC CORROSION ENG PI HOUSTON PA 1440 SOUTH CREEK DRIVE, HOUSTON, TX 77084-4906 USA SN 0094-1492 J9 MATER PERFORMANCE JI Mater. Perform. PD NOV PY 2013 VL 52 IS 11 BP 37 EP 41 PG 5 WC Materials Science, Characterization & Testing SC Materials Science GA 249KR UT WOS:000326776600013 ER PT J AU Merkle, LD Ter-Gabrielyan, N Kacik, NJ Sanamyan, T Zhang, HJ Yu, HH Wang, JY Dubinskii, M AF Merkle, Larry D. Ter-Gabrielyan, Nikolay Kacik, Natalie J. Sanamyan, Tigran Zhang, Huaijin Yu, Haohai Wang, Jiyang Dubinskii, Mark TI Er:Lu2O3 - Laser-related spectroscopy SO OPTICAL MATERIALS EXPRESS LA English DT Article ID SOLID-STATE LASERS; CRYSTALS; ER3+; ABSORPTION; RANGE; SC2O3 AB The spectra of Er:Lu2O3 have been studied between 7 K and room temperature, particularly for transitions between the I-4(13/2) and I-4(15/2) manifolds. This includes the determination of energy levels for Er in the C-2 site and some levels for the C-3i site, as well as absorption and stimulated emission cross sections and radiative lifetimes. At cryogenic temperatures, the emission lines at 1576 and 1601 nm are promising for laser operation, and the unusual breadth of the 1535-nm zero line makes it attractive for diode laser pumping, thus providing the potential for very small quantum defect lasing. (C) 2013 Optical Society of America C1 [Merkle, Larry D.; Ter-Gabrielyan, Nikolay; Kacik, Natalie J.; Sanamyan, Tigran; Dubinskii, Mark] US Army Res Lab, ATTN RDRL SEE M, Adelphi, MD 20783 USA. [Zhang, Huaijin; Yu, Haohai; Wang, Jiyang] Shandong Univ, State Key Lab Crystal Mat, Jinan 250100, Peoples R China. RP Merkle, LD (reprint author), US Army Res Lab, ATTN RDRL SEE M, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM larry.d.merkle.civ@mail.mil FU National Science Foundation of China [51032004, 51102156] FX The authors thank Akio Ikesue for providing the ceramic samples. H.Z., H.Y., and J.W. gratefully acknowledge the support of the National Science Foundation of China, projects 51032004 and 51102156. NR 25 TC 0 Z9 0 U1 3 U2 40 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 2159-3930 J9 OPT MATER EXPRESS JI Opt. Mater. Express PD NOV 1 PY 2013 VL 3 IS 11 BP 1992 EP 2002 DI 10.1364/OME.3.001992 PG 11 WC Materials Science, Multidisciplinary; Optics SC Materials Science; Optics GA 248EH UT WOS:000326676000023 ER PT J AU Garcia-Berrios, E Theriot, JC Woodka, MD Lewis, NS AF Garcia-Berrios, Edgardo Theriot, Jordan C. Woodka, Marc D. Lewis, Nathan S. TI Detection of ammonia, 2,4,6-trinitrotoluene, and common organic vapors using thin-film carbon black-metalloporphyrin composite chemiresistors SO SENSORS AND ACTUATORS B-CHEMICAL LA English DT Article DE Porphyrins; Carbon black composites; Electronic nose; Principal components analysis (PCA); 2,4,6 Trinitrotoluene ID TNT VAPOR; POLYMERS; INFORMATION; ARRAYS AB Thin-film chemiresistive composites of octaethylporphine-based transition-metal complexes (Ph(M), M= Co, Cu and Zn) and carbon black (CB) have been fabricated and tested as chemical vapor sensors. The sensing performance of such sensor composites was compared to the sensing performance of composites of metallophthalocyanines (Phtc(M)) and CB. The relative differential resistance response of Ph(M)/CB sensor films upon exposure to organic vapors, such as n-hexane, n-heptane, n-octane, iso-octane, cyclohexane, toluene, ethyl acetate and ethanol, was dependent on the nature of the metal center. An array of chemiresistive Ph(M)/CB vapor sensors therefore provided discrimination between the organic vapor analytes that had different polarities, specifically classifying non-polar vapors, aprotic polar vapors and protic polar vapors. However, discrimination was not observed for analytes that had mutually similar polarities. The Ph(M)/CB sensors showed reversible responses toward ammonia, NH3(g), at concentrations below the 8 h permissible exposure level (50 ppm). Ph(M)/CB composites exhibited a slightly larger resistance response than Phtc(M)/CB composites, consistent with the Ph(M) species having less Tr-stacked molecular aggregates, resulting in an increase in the number of adsorption sites relative to the Phtc(M)/CB composites. Resistance responses with a signal-to-noise ratio value of -900 were obtained upon exposure to vapor pulses saturated with 2,4,6-trinitrotoluene. (C) 2013 Published by Elsevier B.V. C1 [Garcia-Berrios, Edgardo; Theriot, Jordan C.; Woodka, Marc D.; Lewis, Nathan S.] CALTECH, Beckman Inst, Noyes Lab 210, Pasadena, CA 91125 USA. [Garcia-Berrios, Edgardo; Theriot, Jordan C.; Woodka, Marc D.; Lewis, Nathan S.] CALTECH, Kavli Nanosci Inst, Div Chem & Chem Engn, Pasadena, CA 91125 USA. [Woodka, Marc D.] United States Army, RDECOM CERDEC Night Vis & Elect Sensors Directora, Ft Belvoir, VA 22060 USA. RP Lewis, NS (reprint author), CALTECH, Beckman Inst, Noyes Lab 210, 127-72, Pasadena, CA 91125 USA. EM nslewis@caltech.edu FU Molecular Materials Research Center of the Beckman Institute at the California Institute of Technology; Boeing Inc.; Next Dimension Technologies for donation of materials; NSF FX The authors thank Professor S. Maldonado, Dr. B.S. Brunschwig and Dr. \W. Royea for helpful discussions. We gratefully acknowledge the DHS, the NSF, the Molecular Materials Research Center of the Beckman Institute at the California Institute of Technology, and Boeing Inc. for financial support, in addition to Next Dimension Technologies for donation of materials used in this work. The NSF is acknowledged for a graduate fellowship to Edgardo Garcia-Berrios. NR 25 TC 7 Z9 7 U1 1 U2 33 PU ELSEVIER SCIENCE SA PI LAUSANNE PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND SN 0925-4005 J9 SENSOR ACTUAT B-CHEM JI Sens. Actuator B-Chem. PD NOV PY 2013 VL 188 BP 761 EP 767 DI 10.1016/j.snb.2013.07.006 PG 7 WC Chemistry, Analytical; Electrochemistry; Instruments & Instrumentation SC Chemistry; Electrochemistry; Instruments & Instrumentation GA 243VE UT WOS:000326345600102 ER PT J AU Simard, JM Popovich, PG Tsymbalyuk, O Caridi, J Gullapalli, RP Kilbourne, MJ Gerzanich, V AF Simard, J. M. Popovich, P. G. Tsymbalyuk, O. Caridi, J. Gullapalli, R. P. Kilbourne, M. J. Gerzanich, V. TI MRI evidence that glibenclamide reduces acute lesion expansion in a rat model of spinal cord injury SO SPINAL CORD LA English DT Article DE spinal cord injury; glibenclamide; riluzole; Sur1-Trpm4 channel; MRI; progressive hemorrhagic necrosis ID ISCHEMIC-STROKE; HEMORRHAGE; RILUZOLE; CHANNEL AB Study design: Experimental, controlled, animal study. Objectives: To use non-invasive magnetic resonance imaging (MRI) to corroborate invasive studies showing progressive expansion of a hemorrhagic lesion during the early hours after spinal cord trauma and to assess the effect of glibenclamide, which blocks Sur1-Trpm4 channels implicated in post-traumatic capillary fragmentation, on lesion expansion. Setting: Baltimore. Methods: Adult female Long-Evans rats underwent unilateral impact trauma to the spinal cord at C7, which produced ipsilateral but not contralateral primary hemorrhage. In series 1 (six control rats and six administered glibenclamide), hemorrhagic lesion expansion was characterized using MRI at 1 and 24 h after trauma. In series 2, hemorrhagic lesion size was characterized on coronal tissue sections at 15 min (eight rats) and at 24 h after trauma (eight control rats and eight administered glibenclamide). Results: MRI (T2 hypodensity) showed that lesions expanded 2.3 +/- 0.33-fold (P<0.001) during the first 24 h in control rats, but only 1.2 +/- 0.07-fold (P>0.05) in glibenclamide-treated rats. Measuring the areas of hemorrhagic contusion on tissue sections at the epicenter showed that lesions expanded 2.2 +/- 0.12-fold (P<0.001) during the first 24 h in control rats, but only 1.1 +/- 0.05-fold (P>0.05) in glibenclamide-treated rats. Glibenclamide treatment was associated with significantly better neurological function (unilateral BBB scores) at 24 h in both the ipsilateral (median scores, 9 vs 0; P<0.001) and contralateral (median scores, 12 vs 2; P<0.001) hindlimbs. Conclusion: MRI is an accurate non-invasive imaging biomarker of lesion expansion and is a sensitive measure of the ability of glibenclamide to reduce lesion expansion. C1 [Simard, J. M.; Tsymbalyuk, O.; Caridi, J.; Gerzanich, V.] Univ Maryland, Sch Med, Dept Neurosurg, Baltimore, MD 21201 USA. [Simard, J. M.] Univ Maryland, Sch Med, Dept Pathol, Baltimore, MD 21201 USA. [Simard, J. M.] Univ Maryland, Sch Med, Dept Physiol, Baltimore, MD 21201 USA. [Popovich, P. G.] Ohio State Univ, Coll Med, Ctr Brain & Spinal Cord Repair, Columbus, OH 43210 USA. [Popovich, P. G.] Ohio State Univ, Coll Med, Dept Neurosci, Columbus, OH 43210 USA. [Gullapalli, R. P.] Univ Maryland, Sch Med, Dept Radiol, Baltimore, MD 21201 USA. [Kilbourne, M. J.] Walter Reed Army Med Ctr, Dept Surg, Washington, DC 20307 USA. RP Simard, JM (reprint author), Univ Maryland, Sch Med, Dept Neurosurg, 22 South Greene St,Suite 12SD, Baltimore, MD 21201 USA. EM msimard@smail.umaryland.edu FU Department of Veterans Affairs (Baltimore); National Institute of Neurological Disorders and Stroke (NINDS) [NS060801]; NINDS [NS061934, HHSN271200800040C]; Ray W. Poppleton endowment (OSU); Department of the Army [W81XWH 1010898] FX This work was supported by grants to JMS from the Department of Veterans Affairs (Baltimore) and from the National Institute of Neurological Disorders and Stroke (NINDS) (NS060801); to VG from NINDS (NS061934); to PGP from NINDS (HHSN271200800040C) and from the Ray W. Poppleton endowment (OSU); and to PGP and JMS from the Department of the Army (W81XWH 1010898). NR 28 TC 6 Z9 6 U1 0 U2 1 PU NATURE PUBLISHING GROUP PI LONDON PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND SN 1362-4393 EI 1476-5624 J9 SPINAL CORD JI Spinal Cord PD NOV PY 2013 VL 51 IS 11 BP 823 EP 827 DI 10.1038/sc.2013.99 PG 5 WC Clinical Neurology; Rehabilitation SC Neurosciences & Neurology; Rehabilitation GA 251IP UT WOS:000326921700006 PM 24042989 ER PT J AU Nguyen, KT Seth, AK Hong, SJ Geringer, MR Xie, P Leung, KP Mustoe, TA Galiano, RD AF Nguyen, Khang T. Seth, Akhil K. Hong, Seok J. Geringer, Matthew R. Xie, Ping Leung, Kai P. Mustoe, Thomas A. Galiano, Robert D. TI Deficient cytokine expression and neutrophil oxidative burst contribute to impaired cutaneous wound healing in diabetic, biofilm-containing chronic wounds SO WOUND REPAIR AND REGENERATION LA English DT Article ID STAPHYLOCOCCUS-AUREUS; BACTERIAL BIOFILMS; POLYMORPHONUCLEAR LEUKOCYTES; MATRIX-METALLOPROTEINASES; INNATE IMMUNITY; FOOT ULCERS; ACTIVATION; MICE; MECHANISMS; EPITHELIUM AB Diabetic patients exhibit dysregulated inflammatory and immune responses that predispose them to chronic wound infections and the threat of limb loss. The molecular underpinnings responsible for this have not been well elucidated, particularly in the setting of wound biofilms. This study evaluates host responses in biofilm-impaired wounds using the TallyHo mouse, a clinically relevant polygenic model of type 2 diabetes. No differences in cytokine or Toll-like receptor (TLR) expression were noted in unwounded skin or noninoculated wounds of diabetic and wild-type mice. However, diabetic biofilm-containing wounds had significantly less TLR 2, TLR 4, interleukin-1, and tumor necrosis factor- expression than wild-type wounds with biofilm (all p<0.001). Both groups had similar bacterial burden and neutrophil infiltration after development of biofilms at 3 days postwounding, but diabetic wounds had significantly less neutrophil oxidative burst activity. This translated into a log-fold greater bacterial burden and significant delay of wound epithelization for biofilm-impaired diabetic wounds at 10 days postwounding. These results suggest that impaired recognition of bacterial infection via the TLR pathway leading to inadequate cytokine stimulation of antimicrobial host responses may represent a potential mechanism underlying diabetic susceptibility to wound infection and ulceration. C1 [Nguyen, Khang T.; Seth, Akhil K.; Hong, Seok J.; Geringer, Matthew R.; Xie, Ping; Mustoe, Thomas A.; Galiano, Robert D.] Northwestern Univ, Feinberg Sch Med, Div Plast Surg, Chicago, IL 60611 USA. [Leung, Kai P.] US Army, Inst Surg Res, Microbiol Branch, Ft Sam Houston, TX 78234 USA. RP Galiano, RD (reprint author), Northwestern Univ, Feinberg Sch Med, Div Plast Surg, 675 N St Clair,Suite 19-250, Chicago, IL 60611 USA. EM rgaliano@nmh.org FU Departmental Funds FX Source of Funding: Departmental Funds. NR 42 TC 16 Z9 16 U1 2 U2 16 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1067-1927 EI 1524-475X J9 WOUND REPAIR REGEN JI Wound Repair Regen. PD NOV PY 2013 VL 21 IS 6 BP 833 EP 841 DI 10.1111/wrr.12109 PG 9 WC Cell Biology; Dermatology; Medicine, Research & Experimental; Surgery SC Cell Biology; Dermatology; Research & Experimental Medicine; Surgery GA 243OU UT WOS:000326327100154 PM 24118295 ER PT J AU Burmeister, DM AbouShwareb, T Bergman, CR Andersson, KE Christ, GJ AF Burmeister, David M. AbouShwareb, Tamer Bergman, Christopher R. Andersson, Karl-Erik Christ, George J. TI Age-Related Alterations in Regeneration of the Urinary Bladder after Subtotal Cystectomy SO AMERICAN JOURNAL OF PATHOLOGY LA English DT Article ID ACELLULAR MATRIX GRAFT; RAT BLADDER; OUTLET OBSTRUCTION; DETRUSOR MUSCLE; STEM-CELLS; INNERVATION; EXPRESSION; CAPACITY; CANCER; MODEL AB Prior work documented that surgical removal of approximately 70% of the bladder (subtotal cystectomy) in 12-week-old female rats induced complete functional regeneration of the bladder within 8 weeks. To determine whether animal age affects bladder regeneration, female F344 rats aged 12 weeks (young) and 12 months (old) underwent subtotal cystectomy, and then were evaluated from 1 to 26 weeks after subtotal cystectomy. At 26 weeks after subtotal cystectomy, bladder capacity in young animals was indistinguishable from that in age-matched controls, but bladder capacity in old animals was only approximately 56% of that in age-matched controls. There was no detectable difference in residual volume among treatment groups, but the diminished regeneration in old animals was associated with a corresponding increase in the ratio of residual volume to micturition volume. The majority of old animals exhibited evidence of chronic kidney damage after subtotal cystectomy. Maximal contraction of bladder strips to electrical field stimulation, as well as activation with carbachol, phenylephrine, and KCl, were Lower in old than in young animals at 26 weeks after subtotal cystectomy. Immunostaining with proliferating cell nuclear antigen and Von Willebrand factor revealed delayed and/or diminished proliferative and angiogenic responses, respectively, in old animals. These results confirm prior work and suggest that multiple mechanisms may contribute to an age-related decline in the regenerative capacity of the bladder. C1 [Burmeister, David M.; Christ, George J.] US Army Inst Surg Res, Ft Sam Houston, TX USA. [AbouShwareb, Tamer; Bergman, Christopher R.; Andersson, Karl-Erik] Wake Forest Univ, Bowman Gray Sch Med, Wake Forest Inst Regenerat Med, Winston Salem, NC 27101 USA. RP Christ, GJ (reprint author), Wake Forest Univ, Baptist Med Ctr, Wake Forest Inst Regenerat Med, Richard H Dean Biomed Res Bldg,Room 257,391 Techn, Winston Salem, NC 27101 USA. EM gchrist@wakehealth.edu FU NIH [R21-DK081832] FX Supported by NIH grant no. R21-DK081832 (G.J.C.). NR 46 TC 1 Z9 1 U1 0 U2 1 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0002-9440 EI 1525-2191 J9 AM J PATHOL JI Am. J. Pathol. PD NOV PY 2013 VL 183 IS 5 BP 1585 EP 1595 DI 10.1016/j.ajpath.2013.07.018 PG 11 WC Pathology SC Pathology GA 246QE UT WOS:000326553400024 PM 24012523 ER PT J AU Cole, WR Arrieux, JP Schwab, K Ivins, BJ Qashu, FM Lewis, SC AF Cole, Wesley R. Arrieux, Jacques P. Schwab, Karen Ivins, Brian J. Qashu, Felicia M. Lewis, Steven C. TI TestRetest Reliability of Four Computerized Neurocognitive Assessment Tools in an Active Duty Military Population SO ARCHIVES OF CLINICAL NEUROPSYCHOLOGY LA English DT Article DE Reliability; Cognitive screening; Traumatic brain injury; Concussion; Military; NCAT ID TRAUMATIC BRAIN-INJURY; TEST-RETEST RELIABILITY; COUNSELING PSYCHOMETRIC ISSUES; REDICK CLINICAL UTILITY; NEUROPSYCHOLOGICAL ASSESSMENT; IMPACT ASSESSMENT; TEST-PERFORMANCE; HEAD-INJURY; CONCUSSION; SPORT AB Computerized neurocognitive assessment tools (NCATs) are increasingly used for baseline and post-concussion assessments. To date, NCATs have not demonstrated strong testretest reliabilities. Most studies have used non-military populations and different methodologies, complicating the determination of the utility of NCATs in military populations. The testretest reliability of four NCATs (Automated Neuropsychological Assessment Metrics 4 [ANAM4], CNS-Vital Signs, CogState, and Immediate Post-Concussion Assessment and Cognitive Test [ImPACT]) was investigated in a healthy active duty military sample. Four hundred and nineteen Service Members were randomly assigned to take one NCAT and 215 returned after approximately 30 days for retest. Participants deemed to have inadequate effort during one or both testing sessions, according to the NCATs scoring algorithms, were removed from analyses. Each NCAT had at least one reliability score (intraclass correlation) in the adequate range (.70.79), only ImPACT had one score considered high (.80.89), and no scores met very high criteria (.90.99). However, overall testretest reliabilities in four NCATs in a military sample are consistent with reliabilities reported in the literature and are lower than desired for clinical decision-making. C1 [Cole, Wesley R.; Arrieux, Jacques P.; Lewis, Steven C.] Womack Army Med Ctr, Ft Bragg, NC 28310 USA. [Cole, Wesley R.; Arrieux, Jacques P.; Lewis, Steven C.] DVBIC, Ft Bragg, NC USA. [Schwab, Karen; Ivins, Brian J.; Qashu, Felicia M.] DVBIC, Silver Spring, MD USA. RP Cole, WR (reprint author), Womack Army Med Ctr, Dept Brain Injury Med, Ft Bragg, NC 28310 USA. EM wesley.r.cole.ctr@mail.mil FU Defense and Veterans Brain Injury Center; Henry M. Jacskon Foundation; Womack Army Medical Center FX This research was supported by the Defense and Veterans Brain Injury Center and conducted with the oversight and support of the Henry M. Jacskon Foundation and Womack Army Medical Center. NR 42 TC 31 Z9 31 U1 9 U2 20 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 0887-6177 EI 1873-5843 J9 ARCH CLIN NEUROPSYCH JI Arch. Clin. Neuropsychol. PD NOV PY 2013 VL 28 IS 7 BP 732 EP 742 DI 10.1093/arclin/act040 PG 11 WC Psychology, Clinical; Psychology SC Psychology GA 243AS UT WOS:000326289300011 PM 23819991 ER PT J AU Sun, HF Hohl, B Cao, YZ Handwerker, C Rushing, TS Cummins, TK Weiss, J AF Sun, Hongfang Hohl, Brian Cao, Yizheng Handwerker, Carol Rushing, Todd S. Cummins, Toney K. Weiss, Jason TI Jet mill grinding of portland cement, limestone, and fly ash: Impact on particle size, hydration rate, and strength SO CEMENT & CONCRETE COMPOSITES LA English DT Article DE Jet mill grinding; Grinding; Blended cement; Fly ash; Limestone; Fineness ID COMPRESSIVE STRENGTH; ORGANIC-SOLIDS; MORTARS; MICROSTRUCTURE; FINENESS; PASTES; TALC AB While the majority of commercial ordinary portland cement (OPC) is ground using a ball mill or a vertical roller mill, other industries have shown that jet mill grinding can be an alternative approach for grinding materials. This paper investigates the potential application of jet mill grinding for two systems. The first system is a blend of OPC and 15% limestone, and the second system is a blend of OPC and 40% fly ash. It was observed that when jet mill grinding is used, the average particle size of the powders is decreased to approximately 4 mu m or less with a narrower particle size distribution than that achieved using ball milling. In addition to evaluating the size and shape of the particles obtained from the jet mill grinding process, this paper focuses on evaluating, using isothermal calorimetry, the effect these changes in particle size and distribution have on the extent and rate of hydration as well as their effect on the compressive strength of cement pastes or mortars. This study also investigated differences between inter-grinding and blending separately ground materials to form an OPC/limestone mixture. Both inter-ground and separately ground OPC/limestone mortars demonstrated an accelerated hydration at early ages accompanied by an increase in early age strength. This appears to be primarily due to the increased surface area of the finer particles that provides more available surface for the hydration reaction. The inter-grinding appeared to be more effective than grinding the materials separately because an improved graded particle size distribution was obtained. The inter-ground OPC/limestone mixture shows accelerated initial hydration at water to powder ratios (w/p, where powder = cement + limestone) of 0.50 and 0.35 when compared with the samples before grinding. At the lower w/p of 0.35, the OPC/Iimestone mixture appears much more efficient. In the OPC/fly ash mixture, jet mill grinding also accelerates the rate of hydration and strength development. (C) 2013 Elsevier Ltd. All rights reserved. C1 [Sun, Hongfang; Cao, Yizheng; Handwerker, Carol; Weiss, Jason] Purdue Univ, Sch Mat Engn, W Lafayette, IN 47907 USA. [Sun, Hongfang] Purdue Univ, Birck Nanotechnol Ctr, W Lafayette, IN 47907 USA. [Hohl, Brian] TPF Enterprises LLC, Niagara Falls, NY 14305 USA. [Rushing, Todd S.; Cummins, Toney K.] US Army, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Weiss, J (reprint author), Purdue Univ, Sch Civil Engn, 1284 Civil Engn Bldg,Room G215, W Lafayette, IN 47907 USA. EM wjweiss@purdue.edu OI Weiss, William/0000-0003-2859-7980 FU U.S. Army Corps of Engineers [104391] FX The authors acknowledge the financial support of the U.S. Army Corps of Engineers (Grant No. 104391). Most of this work was conducted in the Charles Pankow Concrete Materials Laboratory and the Materials Sensing and Characterization Laboratory at Purdue University; as such the authors gratefully acknowledge the support which has made this laboratory and its operation possible. The authors extend appreciation to Javier Castro for his assistance in the use of the calorimeter. Permission to publish was granted by Director, Geotechnical and Structures Laboratory. NR 36 TC 9 Z9 10 U1 1 U2 37 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0958-9465 EI 1873-393X J9 CEMENT CONCRETE COMP JI Cem. Concr. Compos. PD NOV PY 2013 VL 44 BP 41 EP 49 DI 10.1016/j.cemconcomp.2013.03.023 PG 9 WC Construction & Building Technology; Materials Science, Composites SC Construction & Building Technology; Materials Science GA 245AX UT WOS:000326432400005 ER PT J AU Goetz, A Baker, B Buehrens, T Quinn, TP AF Goetz, A. Baker, B. Buehrens, T. Quinn, T. P. TI Diversity of movements by individual anadromous coastal cutthroat trout Oncorhynchus clarkii clarkii SO JOURNAL OF FISH BIOLOGY LA English DT Article DE behaviour; estuary; migration; Puget Sound; salmonid; telemetry ID REARED ATLANTIC SALMON; VISUAL PREY DETECTION; BROWN TROUT; VERTICAL MOVEMENTS; BRITISH-COLUMBIA; PACIFIC SALMON; HABITAT USE; ULTRASONIC TELEMETRY; SEASONAL PATTERNS; LAKE WASHINGTON AB Wild, downstream-migrating cutthroat trout, Oncorhynchus clarkii clarkii, smolts and adults were captured at a weir in Big Beef Creek, Hood Canal, Washington, surgically implanted with acoustic tags and tracked to identify spring and summer movements using stationary receivers in order to test the assumption that the species moves little while in marine waters. Overall, 93-96% migrated from the stream into the east side of the long narrow fjord, where they dispersed north and south along the shoreline. Most O. c. clarkii were detected nearshore within 10km of the release site, with declining detection rates to 77km. Over one-third (36%) crossed c. 2-4km of deep water to the other side but only one O. c. clarkii left the Hood Canal basin. Movements and behaviour patterns did not differ between smolts and adults but cluster analysis revealed two modes of distribution, here categorized as residents and migrants. Within these categories of overall distribution, a range of finer-scale behaviour patterns was observed, including sedentary individuals, daily moving between proximate sites and more continuous long-distance travel. Diel movement patterns varied markedly among individuals but overall activity increased near dawn, peaked around mid-day and declined but continued at night. These patterns contrast with sympatric and closely related steelhead trout, Oncorhynchus mykiss, providing new insights into the diversity of salmonid behaviour. (C) 2013 The Fisheries Society of the British Isles C1 [Goetz, A.; Baker, B.; Buehrens, T.; Quinn, T. P.] Univ Washington, Sch Aquat & Fishery Sci, Seattle, WA 98105 USA. [Goetz, A.] US Army Corps Engineers, Seattle, WA 98134 USA. [Baker, B.] NOAA Fisheries, Alaska Fisheries Sci Ctr, Resource Assessment & Conservat Engn Div, Seattle, WA 98115 USA. [Buehrens, T.] Wild Fish Conservancy, Duvall, WA 98019 USA. RP Goetz, A (reprint author), Univ Washington, Sch Aquat & Fishery Sci, 1122 NE Boat St, Seattle, WA 98105 USA. EM fred.goetz@usace.army.mil FU H. Mason Keeler Endowment at the University of Washington (UW); U.S. Army Corps of Engineers; NOAA Fisheries FX The authors thank T. Johnson, M. Gillum and K. Sheilds (Washington Department of Fish and Wildlife) for support in O. c. clarkii collection and receiver deployments. R. Endicott, J. Lee, R. Bush, K. Frick, S. Katz, G. Brooks, K. Andrews and N. Tolimieri (NOAA Fisheries), E. Jeanes and C. Morello (R2), M. Racine and volunteer divers (Washington Scuba Alliance), S. Larson (Seattle Aquarium), J. Blaine and J. Devereaux (King County) and C. Ebel (U.S. Army Corps) assisted with receiver deployment and recovery, and D. Goetz assisted with mobile tracking. J. Scheuerell and C. Ewing assisted in the development and management of the Hydra website and D. Kim and M. Brown assisted with data analysis. The POST Project provided detection data from Admiralty Inlet and the Strait of Juan de Fuca. This research directly supports the stated purpose of the Census of Marine Life. This study was supported by the H. Mason Keeler Endowment at the University of Washington (UW), U.S. Army Corps of Engineers and NOAA Fisheries. D. Beauchamp and T. Essington (UW) provided reviews and comments. S. Tezak, B. Berejikian and M. Moore (NOAA) are especially recognized for their assistance and collaborative efforts in conducting O. c. clarkii and O. mykiss research, and D. Van Doornik (NOAA) for genetic identification of O. c. clarkii NR 68 TC 1 Z9 1 U1 2 U2 16 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0022-1112 EI 1095-8649 J9 J FISH BIOL JI J. Fish Biol. PD NOV PY 2013 VL 83 IS 5 BP 1161 EP 1182 DI 10.1111/jfb.12209 PG 22 WC Fisheries; Marine & Freshwater Biology SC Fisheries; Marine & Freshwater Biology GA 245PU UT WOS:000326476700005 ER PT J AU Coronges, KA Miller, KA Tamayo, CI Ender, MG AF Coronges, Kathryn A. Miller, Katherine A. Tamayo, Christina I. Ender, Morten G. TI A Network Evaluation of Attitudes Toward Gays and Lesbians Among U.S. Military Cadets SO JOURNAL OF HOMOSEXUALITY LA English DT Article DE cadets; Don't Ask; Don't Tell (DADT); gay and lesbian; homosexual; military; social network analysis; West Point ID SOCIAL NETWORKS; OPINION LEADERS; MEN; ASSOCIATIONS; SMOKING; WOMEN AB The U.S. military's ban on open homosexuality has become an increasingly salient issue since its implementation in 1993 and its repeal in 2011. The military is an organization with a unique professional and social organization. Evaluating military attitudes from a network perspective may offer insight into the role of formal and informal leadership in engendering attitudinal change and cultural tolerance around homosexuality. This study evaluates the role of network centrality and network exposure across formal (command networks) and informal (friendship and perceived leadership networks) structures on attitudes toward homosexuality in the military. This work analyzes survey data from a single cadet company within the U.S. Military Academy (n = 139) prior to the repeal of Don't Ask, Don't Tell. Results indicate that popular students tend to show tolerance toward homosexuality, whereas those who hold command leadership positions are more likely to have personal and professional opposition to homosexuality. In addition, formal superior-subordinate relationships are somewhat more likely to suggest social contagion compared to informal leadership and friendship relationships. Recommendations offer guidance for training strategies particularly with respect to a military leaders and socialization. Future research should monitor these issues relative to the post-DADT environment. C1 [Coronges, Kathryn A.; Ender, Morten G.] US Mil Acad, West Point, NY 10996 USA. [Miller, Katherine A.] Ctr Amer Progress, Washington, DC USA. [Tamayo, Christina I.] US Army, Washington, DC USA. RP Coronges, KA (reprint author), US Mil Acad, Thayer Hall 282G,601 Cullum R, West Point, NY 10996 USA. EM kathryn.coronges@usma.edu NR 58 TC 2 Z9 2 U1 0 U2 17 PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND SN 0091-8369 EI 1540-3602 J9 J HOMOSEXUAL JI J. Homosex. PD NOV 1 PY 2013 VL 60 IS 11 BP 1557 EP 1580 DI 10.1080/00918369.2013.824322 PG 24 WC Psychology, Multidisciplinary; Social Sciences, Interdisciplinary SC Psychology; Social Sciences - Other Topics GA 243HF UT WOS:000326306800002 PM 24147587 ER PT J AU Pasiakos, SM Austin, KG Lieberman, HR Askew, EW AF Pasiakos, Stefan M. Austin, Krista G. Lieberman, Harris R. Askew, E. Wayne TI Efficacy and Safety of Protein Supplements for US Armed Forces Personnel: Consensus Statement SO JOURNAL OF NUTRITION LA English DT Article; Proceedings Paper CT Efficacy and Safety of Protein Supplements for U S Armed Forces Personnel Meeting CY NOV 07-08, 2012 CL U S Army Res Inst Environm Med, Natick, MA SP Ctr Alliance Dietary Supplements Res, Dept Def HO U S Army Res Inst Environm Med ID ESSENTIAL AMINO-ACIDS; SKELETAL-MUSCLE PROTEIN; RESISTANCE EXERCISE; ENDURANCE EXERCISE; DIETARY-PROTEIN; MILITARY PERSONNEL; GENDER-DIFFERENCES; ANABOLIC RESPONSE; DOSE-RESPONSE; LEUCINE AB To provide evidence-based guidance regarding the efficacy and safety of dietary protein supplement (PS) use by members of the U.S. Armed Forces, a panel of internationally recognized experts in the fields of protein metabolism and dietary supplement research was convened by the Department of Defense Center Alliance for Dietary Supplement Research and the U.S. Army Medical Research and Material Command. To develop a consensus statement, potential benefits, risks, and strategies to optimize military performance through PS use were considered in the context of specific warfighter populations and occupational demands. To maintain muscle mass, strength, and performance during periods of substantial metabolic demand and concomitant negative energy balance the panel recommended that warfighters consume 1.5-2.0 g kg(-1) . d(-1) of protein. However, if metabolic demand is low, such as in garrison, protein intake should equal the current Military Dietary Reference Intake (0.8-1.5 g kg(-1) . d(-1)). Although PS use generally appears to be safe for healthy adults, warfighters should be educated on PS quality, given quality-control and contamination concerns with commercial dietary supplements. To achieve recommended protein intakes, the panel strongly urges consumption of high-quality protein-containing whole foods. However, when impractical, the use of PSs (20-25 g per serving or 0.25-0.3 g . kg(-1) per meal), particularly after periods of strenuous physical activity (e.g., military training, combat patrols, and exercise), is acceptable. The committee acknowledges the need for further study of protein requirements for extreme, military-specific environmental conditions and whether unique metabolic stressors associated with military service alter protein requirements for aging warfighters. C1 [Pasiakos, Stefan M.; Austin, Krista G.; Lieberman, Harris R.] US Army, Mil Nutr Div, Environm Med Res Inst, Natick, MA 01760 USA. [Askew, E. Wayne] Univ Utah, Coll Hlth, Div Nutr, Salt Lake City, UT USA. RP Lieberman, HR (reprint author), US Army, Mil Nutr Div, Environm Med Res Inst, Natick, MA 01760 USA. RI Pasiakos, Stefan/E-6295-2014 OI Pasiakos, Stefan/0000-0002-5378-5820 NR 39 TC 15 Z9 17 U1 0 U2 11 PU AMER SOC NUTRITION-ASN PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 0022-3166 EI 1541-6100 J9 J NUTR JI J. Nutr. PD NOV PY 2013 VL 143 IS 11 BP 1811 EP 1814 DI 10.3945/jn.113.176859 PG 4 WC Nutrition & Dietetics SC Nutrition & Dietetics GA 240VQ UT WOS:000326126200015 PM 24027189 ER PT J AU Pasiakos, SM Montain, SJ Young, AJ AF Pasiakos, Stefan M. Montain, Scott J. Young, Andrew J. TI Protein Supplementation in US Military Personnel SO JOURNAL OF NUTRITION LA English DT Article; Proceedings Paper CT Efficacy and Safety of Protein Supplements for U S Armed Forces Personnel Meeting CY NOV 07-08, 2012 CL U S Army Res Inst Environm Med, Natick, MA SP Ctr Alliance Dietary Supplements Res, Dept Def HO U S Army Res Inst Environm Med ID DIETARY-SUPPLEMENTS; WEIGHT-LOSS; LOAD CARRIAGE; ARMY SOLDIERS; ENERGY; PERFORMANCE; EXERCISE; HEALTH; NUTRITION; REQUIREMENTS AB Protein supplements (PSs) are, after multivitamins, the most frequently consumed dietary supplement by U.S. military personnel. Warfighters believe that PSs will improve health, promote muscle strength, and enhance physical performance. The estimated prevalence of regular PS use by military personnel is nearly 20% or more in active-duty personnel, which is comparable to collegiate athletes and recreationally active adults, but higher than that for average U.S. civilians. Although the acute metabolic effects of PS ingestion are well described, little is known regarding the benefits of PS use by warfighters in response to the metabolic demands of military operations. When dietary protein intake approaches 1.5g . kg(-1). d(-1), and energy intake matches energy expenditure, the use of PSs by most physically active military personnel may not be necessary. However, dismounted infantry often perform operations consisting of long periods of strenuous physical activity coupled with inadequate dietary energy and protein intake. In these situations, the use of PSs may have efficacy for preserving fat-free mass. This article reviews the available literature regarding the prevalence of PS use among military personnel. Furthermore, it highlights the unique metabolic stressors affecting U.S. military personnel and discusses potential conditions during which protein supplementation might be beneficial. C1 [Pasiakos, Stefan M.; Montain, Scott J.; Young, Andrew J.] US Army, Environm Med Res Inst, Mil Nutr Div, Natick, MA 01760 USA. RP Pasiakos, SM (reprint author), US Army, Environm Med Res Inst, Mil Nutr Div, Natick, MA 01760 USA. RI Pasiakos, Stefan/E-6295-2014 OI Pasiakos, Stefan/0000-0002-5378-5820 NR 47 TC 3 Z9 3 U1 0 U2 8 PU AMER SOC NUTRITION-ASN PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 0022-3166 EI 1541-6100 J9 J NUTR JI J. Nutr. PD NOV PY 2013 VL 143 IS 11 BP 1815 EP 1819 DI 10.3946/jn.113175968 PG 5 WC Nutrition & Dietetics SC Nutrition & Dietetics GA 240VQ UT WOS:000326126200016 ER PT J AU Molloy, JM Aberle, CJ Escobar, E AF Molloy, Joseph M. Aberle, Curtis J. Escobar, Eduardo TI Triceps Tendon Tear in a Middle-Aged Weightlifter SO JOURNAL OF ORTHOPAEDIC & SPORTS PHYSICAL THERAPY LA English DT Editorial Material C1 [Molloy, Joseph M.] US Army Garrison Yongsan, Brian Allgood Army Community Hosp, Dept Surg, Seoul, South Korea. [Aberle, Curtis J.] Brooke Army Med Ctr, McWethy Troop Med Clin, Ft Sam Houston, TX 78234 USA. [Escobar, Eduardo] Brooke Army Med Ctr, Dept Radiol, Ft Sam Houston, TX 78234 USA. RP Molloy, JM (reprint author), US Army Garrison Yongsan, Brian Allgood Army Community Hosp, Dept Surg, Seoul, South Korea. NR 0 TC 0 Z9 0 U1 0 U2 1 PU J O S P T, PI ALEXANDRIA PA 1111 NORTH FAIRFAX ST, STE 100, ALEXANDRIA, VA 22314-1436 USA SN 0190-6011 J9 J ORTHOP SPORT PHYS JI J. Orthop. Sports Phys. Ther. PD NOV PY 2013 VL 43 IS 11 BP 848 EP 848 DI 10.2519/jospt.2013.0419 PG 1 WC Orthopedics; Rehabilitation; Sport Sciences SC Orthopedics; Rehabilitation; Sport Sciences GA 245TN UT WOS:000326486800009 PM 24175622 ER PT J AU Ingram, T Silvernail, J AF Ingram, Tony Silvernail, Jason TI A CAUTIONARY NOTE ON ENDORSING THE PLACEBO EFFECT SO JOURNAL OF ORTHOPAEDIC & SPORTS PHYSICAL THERAPY LA English DT Letter ID RANDOMIZED CONTROLLED-TRIAL; LOW-BACK-PAIN; OUTCOMES; THERAPY; INTERVENTIONS; EXPECTATIONS C1 [Ingram, Tony] Eastern Hlth, St John, NF, Canada. [Ingram, Tony] Mem Univ Newfoundland, Sch Human Kinet & Recreat, St John, NF, Canada. [Silvernail, Jason] First Brigade, Armored Div 1, Ft Bliss, TX USA. RP Ingram, T (reprint author), Eastern Hlth, St John, NF, Canada. NR 16 TC 2 Z9 2 U1 2 U2 4 PU J O S P T, PI ALEXANDRIA PA 1111 NORTH FAIRFAX ST, STE 100, ALEXANDRIA, VA 22314-1436 USA SN 0190-6011 J9 J ORTHOP SPORT PHYS JI J. Orthop. Sports Phys. Ther. PD NOV PY 2013 VL 43 IS 11 BP 849 EP 851 PG 3 WC Orthopedics; Rehabilitation; Sport Sciences SC Orthopedics; Rehabilitation; Sport Sciences GA 245TN UT WOS:000326486800010 PM 24175623 ER PT J AU Foran, HM Wright, KM Wood, MD AF Foran, Heather M. Wright, Kathleen M. Wood, Michael D. TI DO COMBAT EXPOSURE AND POST-DEPLOYMENT MENTAL HEALTH INFLUENCE INTENT TO DIVORCE? SO JOURNAL OF SOCIAL AND CLINICAL PSYCHOLOGY LA English DT Article ID POSTTRAUMATIC-STRESS-DISORDER; IRAQI FREEDOM VETERANS; RELATIONSHIP SATISFACTION; INTIMATE-RELATIONSHIPS; PHYSICAL AGGRESSION; PARTNER VIOLENCE; EARLY MARRIAGE; PRIMARY-CARE; RISK-FACTORS; SYMPTOMS AB The period after returning from combat deployment is a dynamic time for relationships. Anecdotally, some couples report their relationship is stronger after the deployment and others report the onset of marital problems. In a sample of 194 soldiers, we examined the association between combat exposure, mental health symptoms, aggressive behaviors, and intent to divorce or separate during the 4- and 9- month post-deployment period. At time 1, 37% soldiers reported problems in their marriage and the degree of marital distress was positively associated with PTSD symptoms, depressive symptoms, and aggression. Time 2 intent to divorce or separate was bivariately associated with Time 1 marital distress, relationship psychological aggression, and PTSD re-experiencing symptoms; there were also trends for combat exposure and general aggression to be bivariately associated with Time 2 intent to divorce or separate. Further, there was a significant interaction between marital distress and combat exposure such that military personnel with a combination of high levels of combat exposure and marital distress were at heightened risk for intent to divorce at Time 2, even after accounting for PTSD symptoms. This finding suggests higher levels of combat exposure may influence willingness to stay in a distressed marriage; possible mechanisms for this, such as changes in life priorities, are discussed. C1 [Foran, Heather M.; Wright, Kathleen M.; Wood, Michael D.] US Army Med Res Unit Europe, Walter Reed Army Inst Res, D-69126 Heidelberg, Germany. RP Foran, HM (reprint author), US Army Med Res Unit Europe, Nachrichten Kaserne Karlsruher Str 144, D-69126 Heidelberg, Germany. EM heatherforan@gmail.com NR 64 TC 3 Z9 3 U1 3 U2 15 PU GUILFORD PUBLICATIONS INC PI NEW YORK PA 72 SPRING STREET, NEW YORK, NY 10012 USA SN 0736-7236 J9 J SOC CLIN PSYCHOL JI J. Soc. Clin. Psychol. PD NOV PY 2013 VL 32 IS 9 BP 917 EP 938 PG 22 WC Psychology, Clinical; Psychology, Social SC Psychology GA 244XE UT WOS:000326422700001 ER PT J AU Kinley, GE Fitzgerald, JK Facemire, PR AF Kinley, Gwynne E. Fitzgerald, Julie K. Facemire, Paul R. TI Complicated urolithiasis in a Long Evans rat SO LAB ANIMAL LA English DT Article ID URINARY-TRACT-INFECTION; PROTEUS-MIRABILIS C1 [Kinley, Gwynne E.; Fitzgerald, Julie K.; Facemire, Paul R.] Naval Med Res Ctr, Walter Reed Army Inst Res, Vet Serv Program, Silver Spring, MD 20910 USA. RP Fitzgerald, JK (reprint author), Naval Med Res Ctr, Walter Reed Army Inst Res, Vet Serv Program, Silver Spring, MD 20910 USA. EM julie.k.fitzgerald2.mil@mail.mil NR 20 TC 1 Z9 1 U1 0 U2 1 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 0093-7355 EI 1548-4475 J9 LAB ANIMAL JI Lab Anim. PD NOV PY 2013 VL 42 IS 11 BP 417 EP 420 PG 4 WC Veterinary Sciences SC Veterinary Sciences GA 245UB UT WOS:000326488200019 PM 24150168 ER PT J AU Lisal, M Predota, M Brennan, JK AF Lisal, Martin Predota, Milan Brennan, John K. TI Molecular-level simulations of chemical reaction equilibrium and diffusion in slit and cylindrical nanopores: model dimerisation reactions SO MOLECULAR SIMULATION LA English DT Article DE molecular dynamics; reaction ensemble Monte Carlo; slit and cylindrical nanopores ID REACTION ENSEMBLE METHOD; LENNARD-JONES FLUIDS; MONTE-CARLO METHOD; COMPUTER-SIMULATION; PHASE-EQUILIBRIA; POROUS MATERIALS; DYNAMICS; CONFINEMENT; ADSORPTION; NANOTUBES AB A molecular-level simulation study of the effects of confinement on chemical reaction equilibrium and diffusion in both slit and cylindrical nanopores is presented. First, the reaction ensemble Monte Carlo (RxMC) method is implemented to investigate the effects of nanopore size and geometry, and bulk pressure on the model dimerisation reaction, 2A B, in slit and cylindrical nanopores in equilibrium with a vapour-phase reservoir. After determining the reaction equilibrium concentrations in the nanopore phase from RxMC simulations, canonical molecular dynamics (MD) is implemented to study the diffusion of fluid mixtures with concentrations matching the final average concentrations from the RxMC simulations. The canonical MD simulations mimic a diffusion-limited reacting system, where it is assumed that the reaction rates are very fast relative to the diffusion, and therefore assumed that chemical equilibrium is effectively maintained and unperturbed at all times in the system. The diffusion is analysed in terms of the overall and space-dependent mean-square displacement and corresponding self-diffusion coefficients. Monomers and dimers are treated as Lennard-Jones (LJ) and two-centre LJ fluids, respectively, while the interactions of the fluids with the nanopore walls are modelled using the Steele 10-4-3 potential. The model parameters and state conditions are chosen in order to enhance reaction conversions in the nanopore phase with respect to the bulk vapour phase. The main result of this work is a relation between the space-dependent diffusion and the structure of the reacting fluids within the nanopores. C1 [Lisal, Martin; Predota, Milan] ASCR, Inst Chem Proc Fundamentals, E Hala Lab Thermodynam, Vvi, Prague 16502 6, Suchdol, Czech Republic. [Lisal, Martin] Univ JE Purkyne, Dept Phys, Fac Sci, Usti Nad Labem 40096, Czech Republic. [Predota, Milan] Univ South Bohemia, Inst Phys & Biophys, Fac Sci, Ceske Budejovice 37005, Czech Republic. [Brennan, John K.] US Army Res Lab, Weap & Mat Res Directorate, Adelphi, MD 21005 USA. RP Lisal, M (reprint author), ASCR, Inst Chem Proc Fundamentals, E Hala Lab Thermodynam, Vvi, Rozvojova 135, Prague 16502 6, Suchdol, Czech Republic. EM lisal@icpf.cas.cz RI Lisal, Martin/A-8176-2011; Predota, Milan/A-2256-2009 OI Lisal, Martin/0000-0001-8005-7143; Predota, Milan/0000-0003-3902-0992 FU Czech Science Foundation [13-09914S, 13-08651S] FX This work was supported by the Czech Science Foundation, projects 13-09914S and 13-08651S. The authors wish to thank Jan Krejci for performing some of the simulations presented in this work. NR 39 TC 2 Z9 2 U1 1 U2 24 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 0892-7022 EI 1029-0435 J9 MOL SIMULAT JI Mol. Simul. PD NOV 1 PY 2013 VL 39 IS 13 BP 1103 EP 1120 DI 10.1080/08927022.2013.797576 PG 18 WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical SC Chemistry; Physics GA 239IE UT WOS:000326015000010 ER PT J AU Dai, TH Gupta, A Huang, YY Sherwood, ME Murray, CK Vrahas, MS Kielian, T Hamblin, MR AF Dai, Tianhong Gupta, Asheesh Huang, Ying-Ying Sherwood, Margaret E. Murray, Clinton K. Vrahas, Mark S. Kielian, Tammy Hamblin, Michael R. TI Blue Light Eliminates Community-Acquired Methicillin-Resistant Staphylococcus aureus in Infected Mouse Skin Abrasions SO PHOTOMEDICINE AND LASER SURGERY LA English DT Article ID MRSA IN-VITRO; VISIBLE-LIGHT; PROPIONIBACTERIUM-ACNES; LOCALIZED INFECTIONS; PHOTODYNAMIC THERAPY; HELICOBACTER-PYLORI; HIGH-INTENSITY; INACTIVATION; BACTERIA; MODEL AB Background and objective: Bacterial skin and soft tissue infections (SSTI) affect millions of individuals annually in the United States. Treatment of SSTI has been significantly complicated by the increasing emergence of community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) strains. The objective of this study was to demonstrate the efficacy of blue light (415 +/- 10nm) therapy for eliminating CA-MRSA infections in skin abrasions of mice. Methods: The susceptibilities of a CA-MRSA strain (USA300LAC) and human keratinocytes (HaCaT) to blue light inactivation were compared by in vitro culture studies. A mouse model of skin abrasion infection was developed using bioluminescent USA300LAC::lux. Blue light was delivered to the infected mouse skin abrasions at 30min (acute) and 24h (established) after the bacterial inoculation. Bioluminescence imaging was used to monitor in real time the extent of infection in mice. Results: USA300LAC was much more susceptible to blue light inactivation than HaCaT cells (p=0.038). Approximately 4.75-log(10) bacterial inactivation was achieved after 170J/cm(2) blue light had been delivered, but only 0.29 log(10) loss of viability in HaCaT cells was observed. Transmission electron microscopy imaging of USA300LAC cells exposed to blue light exhibited disruption of the cytoplasmic content, disruption of cell walls, and cell debris. In vivo studies showed that blue light rapidly reduced the bacterial burden in both acute and established CA-MRSA infections. More than 2-log(10) reduction of bacterial luminescence in the mouse skin abrasions was achieved when 41.4 (day 0) and 108J/cm(2) (day 1) blue light had been delivered. Bacterial regrowth was observed in the mouse wounds at 24h after the blue light therapy. Conclusions: There exists a therapeutic window of blue light for bacterial infections where bacteria are selectively inactivated by blue light while host tissue cells are preserved. Blue light therapy has the potential to rapidly reduce the bacterial load in SSTI. C1 [Dai, Tianhong; Gupta, Asheesh; Huang, Ying-Ying; Sherwood, Margaret E.; Hamblin, Michael R.] Massachusetts Gen Hosp, Wellman Ctr Photomed, Boston, MA 02114 USA. [Vrahas, Mark S.] Massachusetts Gen Hosp, Dept Orthopaed Surg, Boston, MA 02114 USA. [Dai, Tianhong; Huang, Ying-Ying; Hamblin, Michael R.] Harvard Univ, Sch Med, Dept Dermatol, Boston, MA 02115 USA. [Gupta, Asheesh] Def Inst Physiol & Allied Sci, Delhi, India. [Murray, Clinton K.] Brooke Army Med Ctr, Infect Dis Serv, Ft Sam Houston, TX 78234 USA. [Kielian, Tammy] Univ Nebraska Med Ctr, Dept Pathol & Microbiol, Omaha, NE USA. [Hamblin, Michael R.] Harvard MIT Div Hlth Sci & Technol, Cambridge, MA USA. RP Hamblin, MR (reprint author), Massachusetts Gen Hosp, Wellman Ctr Photomed, 40 Blossom St, Boston, MA 02114 USA. EM hamblin@helix.mgh.harvard.edu OI Hamblin, Michael/0000-0001-6431-4605 FU Airlift Research Foundation Extremity Trauma Research Grant [109421]; Center for Orthopaedic Trauma Advancement (COTA)/Smith Nephew Grant [2012-16]; NIH [RO1AI050875] FX This study was supported in part by an Airlift Research Foundation Extremity Trauma Research Grant (grant #109421 to TD), a Center for Orthopaedic Trauma Advancement (COTA)/Smith & Nephew Grant (grant # 2012-16 to TD), and the NIH (grant RO1AI050875 to MRH). NR 39 TC 16 Z9 18 U1 0 U2 11 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1549-5418 EI 1557-8550 J9 PHOTOMED LASER SURG JI Photomed. Laser Surg. PD NOV 1 PY 2013 VL 31 IS 11 BP 531 EP 538 DI 10.1089/pho.2012.3365 PG 8 WC Surgery SC Surgery GA 244PE UT WOS:000326400700005 PM 23406384 ER PT J AU Kaewkungwal, J Pitisuttithum, P Rerks-ngarm, S Nitayaphan, S Khamboonruang, C Kunasol, P Suntharasamai, P Pungpak, S Vanijanonta, S Bussaratid, V Maek-a-Nantawat, W Dhitavat, J Thongcharoen, P Pawarana, R Sabmee, Y Benenson, MW Morgan, P O'Connell, RJ Kim, J AF Kaewkungwal, Jaranit Pitisuttithum, Punnee Rerks-ngarm, Supachai Nitayaphan, Sorachai Khamboonruang, Chirasak Kunasol, Prayura Suntharasamai, Pravan Pungpak, Swangjai Vanijanonta, Sirivan Bussaratid, Valai Maek-a-Nantawat, Wirach Dhitavat, Jittima Thongcharoen, Prasert Pawarana, Rungrawee Sabmee, Yupa Benenson, Mike W. Morgan, Patricia O'Connell, Robert J. Kim, Jerome TI Issues in Women's Participation in a Phase III Community HIV Vaccine Trial in Thailand SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Article ID CLINICAL-TRIALS; PREVENTION TRIALS; EFFICACY TRIAL; SOUTH-AFRICA; VOLUNTEERS; DISCRIMINATION; PREPAREDNESS; RECRUITMENT; INFECTION; COUNTRIES AB To assess qualities and outcomes of women participating in a large, community-based HIV vaccine trial, the present study was conducted among female participants of the RV 144 prime-boost trial in Thailand from 2003 to 2009. Qualities of participation refer to complete vaccination, retention, and status change. Outcomes of participation refer to incident rate, adverse event, and participation impact event. A total of 6,334 (38.6%) women participated in the trial, of whom about 50% were classified as low risk and 11% as high risk. About 85% of participants completed four vaccinations and 76% were included in the per-protocol analysis of the on-time vaccination schedule. More women (88%) completed 42 months follow-up compared with men (85%). Women aged 21 and above had more adverse events compared to younger age groups. More women (5%) compared with men (3%) reported participation impact events (PIEs). High-risk women had more PIEs and a higher infection rate compared to the low-risk group. Complete vaccination and retention on last follow-up were more common in married women aged above 21, and being a housewife. Female volunteers showed the same qualities and outcomes of participation as males in the HIV vaccine trial. There was no statistically significant difference in vaccine efficacy between men and women, especially among the high-risk and married women. The study highlighted the important behavioral, social, and cultural issues that could be considered for future HIV vaccine trial designs. C1 [Kaewkungwal, Jaranit; Pawarana, Rungrawee] Mahidol Univ, Fac Trop Med, Ctr Excellence Biomed & Publ Hlth Informat, Bangkok 10400, Thailand. [Pitisuttithum, Punnee; Suntharasamai, Pravan; Pungpak, Swangjai; Vanijanonta, Sirivan; Bussaratid, Valai; Maek-a-Nantawat, Wirach; Dhitavat, Jittima; Sabmee, Yupa] Mahidol Univ, Fac Trop Med, Vaccine Trial Ctr, Bangkok 10400, Thailand. [Rerks-ngarm, Supachai; Khamboonruang, Chirasak; Kunasol, Prayura] Minist Publ Hlth, Dept Dis Control, Bangkok, Thailand. [Nitayaphan, Sorachai; Benenson, Mike W.; Morgan, Patricia] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Thongcharoen, Prasert] Mahidol Univ, Fac Med, Siriraj Hosp, Bangkok 10400, Thailand. [O'Connell, Robert J.; Kim, Jerome] US Mil HIV Res Program, Rockville, MD USA. RP Pitisuttithum, P (reprint author), Mahidol Univ, Fac Trop Med, Vaccine Trial Ctr, 420-6 Rajvithi Rd, Bangkok 10400, Thailand. EM punnee.pit@mahidol.ac.th NR 41 TC 1 Z9 1 U1 0 U2 7 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0889-2229 EI 1931-8405 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD NOV 1 PY 2013 VL 29 IS 11 SI SI BP 1524 EP 1534 DI 10.1089/aid.2012.0265 PG 11 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA 239PI UT WOS:000326037500514 PM 23343395 ER PT J AU Charuthamrong, P Kaeratiswetanun, W Yamkram, T Sarovat, L Sawangying, T Thaitawat, N Likhitwonnawut, U Vasan, S Robb, M Churikanont, N Getchalarat, S Kroon, E Nitayaphan, S Eamsila, C Sriplienchan, S Ngauy, V AF Charuthamrong, P. Kaeratiswetanun, W. Yamkram, T. Sarovat, L. Sawangying, T. Thaitawat, N. Likhitwonnawut, U. Vasan, S. Robb, M. Churikanont, N. Getchalarat, S. Kroon, E. Nitayaphan, S. Eamsila, C. Sriplienchan, S. Ngauy, V. TI Early and Continuous Engagement of the CAB Is Essential to the Successful Implementation of Invasive Procedures in Clinical Trials SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Meeting Abstract CT Conference on AIDS Vaccine CY OCT 07-10, 2013 CL Barcelona, SPAIN C1 [Charuthamrong, P.] Armed Forces Res Inst Med Sci MHRP AFRIMS, Rayong, Thailand. [Kaeratiswetanun, W.; Yamkram, T.; Thaitawat, N.; Vasan, S.; Churikanont, N.; Getchalarat, S.; Kroon, E.; Sriplienchan, S.; Ngauy, V.] Armed Forces Res Inst Med Sci, Banglamung Dist, Thailand. [Sarovat, L.; Sawangying, T.; Likhitwonnawut, U.] CAB, Bangkok, Thailand. [Robb, M.] US Mil HIV Res Program, Bethesda, MD USA. [Nitayaphan, S.; Eamsila, C.] Royal Thai Army AFRIMS, Bangkok, Thailand. NR 0 TC 0 Z9 0 U1 0 U2 2 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0889-2229 EI 1931-8405 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD NOV 1 PY 2013 VL 29 IS 11 SI SI BP A67 EP A67 PG 1 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA 239PI UT WOS:000326037500168 ER PT J AU Chung, AW Ghebremichael, M Robinson, H Brown, E Choi, I Rolland, M Dugast, A Suscovich, TJ Liao, L Mahan, AE Streeck, H Rerks-Ngarm, S Nitayaphan, S de Souza, MS Pitisuttithum, P Francis, D Michael, NL Kim, JH Bailey-Kellog, C Ackerman, ME Alter, G AF Chung, A. W. Ghebremichael, M. Robinson, H. Brown, E. Choi, I. Rolland, M. Dugast, A. Suscovich, T. J. Liao, L. Mahan, A. E. Streeck, H. Rerks-Ngarm, S. Nitayaphan, S. de Souza, M. S. Pitisuttithum, P. Francis, D. Michael, N. L. Kim, J. H. Bailey-Kellog, C. Ackerman, M. E. Alter, G. TI Distinct HIV-Specific Antibody Fc-Profiles in RV144 and VAX003 Vaccinees SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Meeting Abstract CT Conference on AIDS Vaccine CY OCT 07-10, 2013 CL Barcelona, SPAIN C1 [Chung, A. W.; Ghebremichael, M.; Robinson, H.; Dugast, A.; Suscovich, T. J.; Mahan, A. E.; Alter, G.] Ragon Inst MGH MIT & Harvard, Cambridge, MA USA. [Brown, E.; Choi, I.; Bailey-Kellog, C.; Ackerman, M. E.] Dartmouth Coll, Hanover, NH 03755 USA. [Rolland, M.; Streeck, H.; Michael, N. L.; Kim, J. H.] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD USA. [Liao, L.] Duke Univ, Durham, NC USA. [Rerks-Ngarm, S.] Minist Publ Hlth, Nonthaburi, Thailand. [Nitayaphan, S.; de Souza, M. S.] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Pitisuttithum, P.] Mahidol Univ, Fac Trop Med, Bangkok, Thailand. [Francis, D.] Global Solut Infect Dis, San Francisco, CA USA. RI Dugast, AnneSophie/L-9541-2015 NR 0 TC 0 Z9 0 U1 0 U2 3 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0889-2229 EI 1931-8405 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD NOV 1 PY 2013 VL 29 IS 11 SI SI BP A63 EP A64 PG 2 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA 239PI UT WOS:000326037500158 ER PT J AU Eller, L Manak, M Shutt, A Malia, J Trichavaroj, R Danboise, B Lueer, C Jallow, F Hoelscher, M Geldmacher, C Michael, N Robb, M Peel, S AF Eller, L. Manak, M. Shutt, A. Malia, J. Trichavaroj, R. Danboise, B. Lueer, C. Jallow, F. Hoelscher, M. Geldmacher, C. Michael, N. Robb, M. Peel, S. TI Performance of the Determine HIV 1/2 Ag/Ab Combo Rapid Test on Serial Samples from an Acute Infection Study (RV217) in East Africa and Thailand SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Meeting Abstract CT Conference on AIDS Vaccine CY OCT 07-10, 2013 CL Barcelona, SPAIN C1 [Eller, L.; Manak, M.; Shutt, A.; Robb, M.] Henry M Jackson Fdn, US Mil HIV Res Program, Walter Reed Army Inst Res, Bethesda, MD USA. [Malia, J.; Michael, N.; Peel, S.] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD USA. [Trichavaroj, R.] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Danboise, B.] Walter Reed Project Kericho, Kericho, Kenya. [Lueer, C.; Hoelscher, M.; Geldmacher, C.] Mbeya Med Res Ctr, Mbeya, Tanzania. [Jallow, F.] Makerere Univ, Walter Reed Project, Kampala, Uganda. NR 0 TC 0 Z9 0 U1 0 U2 2 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0889-2229 EI 1931-8405 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD NOV 1 PY 2013 VL 29 IS 11 SI SI BP A73 EP A74 PG 2 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA 239PI UT WOS:000326037500184 ER PT J AU Gordon, SN Vaccari, M Doster, MN Liyanage, NP Pegu, P Schifanella, L Caccuri, F Keele, BF Foulds, KE Shen, X Tomaras, GD Montefiori, DC Roederer, M Ferrari, G Venzon, D Stablien, D Barouch, DH Felber, BK Pavlakis, GN Michael, NL Tartaglia, J Franchini, G AF Gordon, S. N. Vaccari, M. Doster, M. N. Liyanage, N. P. Pegu, P. Schifanella, L. Caccuri, F. Keele, B. F. Foulds, K. E. Shen, X. Tomaras, G. D. Montefiori, D. C. Roederer, M. Ferrari, G. Venzon, D. Stablien, D. Barouch, D. H. Felber, B. K. Pavlakis, G. N. Michael, N. L. Tartaglia, J. Franchini, G. TI Priming with Adenovirus26 Vaccines Affects ALVAC-SIV/gp120 Vaccine Efficacy Tested in a SIVmac251 Challenge Model Performed One-Month Post-Vaccination SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Meeting Abstract CT Conference on AIDS Vaccine CY OCT 07-10, 2013 CL Barcelona, SPAIN C1 [Gordon, S. N.; Vaccari, M.; Doster, M. N.; Liyanage, N. P.; Pegu, P.; Schifanella, L.; Caccuri, F.; Venzon, D.; Felber, B. K.; Pavlakis, G. N.; Franchini, G.] NCI, NIH, Bethesda, MD 20892 USA. [Keele, B. F.] NCI, SAIC Frederick, NIH, Frederick, MD 21701 USA. [Foulds, K. E.; Roederer, M.] NIAID, NIH, Bethesda, MD 20892 USA. [Shen, X.; Tomaras, G. D.] Duke Human Vaccine Inst, Durham, NC USA. [Montefiori, D. C.; Ferrari, G.] Duke Univ, Med Ctr, Durham, NC USA. [Stablien, D.] EMMES Corp, Rockville, MD USA. [Barouch, D. H.] Beth Israel Deaconess Med Ctr, Boston, MD USA. [Michael, N. L.] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD USA. [Tartaglia, J.] Sanofi Pasteur, Swiftwater, PA USA. RI Tomaras, Georgia/J-5041-2016 NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0889-2229 EI 1931-8405 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD NOV 1 PY 2013 VL 29 IS 11 SI SI BP A39 EP A39 PG 1 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA 239PI UT WOS:000326037500092 ER PT J AU Jobe, O Tovanabutra, S Ehrenberg, P Poltavee, K Peachman, KK Chenine, A McLinden, R Thomas, R Kim, J Michael, NL Alving, CR Rao, M AF Jobe, O. Tovanabutra, S. Ehrenberg, P. Poltavee, K. Peachman, K. K. Chenine, A. McLinden, R. Thomas, R. Kim, J. Michael, N. L. Alving, C. R. Rao, M. TI Siglec-1 on Macrophages Is a Major Infectivity Receptor for HIV-1: Differential Effects of GM-CSF and M-CSF on HIV-1 Entry and Replication SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Meeting Abstract CT Conference on AIDS Vaccine CY OCT 07-10, 2013 CL Barcelona, SPAIN C1 [Jobe, O.; Tovanabutra, S.; Ehrenberg, P.; Poltavee, K.; Peachman, K. K.; Chenine, A.; McLinden, R.; Thomas, R.] Henry M Jackson Fdn Adv Mil Med, USMHRP, Bethesda, MD USA. [Kim, J.; Michael, N. L.; Alving, C. R.; Rao, M.] Walter Reed Army Inst Res, USMHRP, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0889-2229 EI 1931-8405 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD NOV 1 PY 2013 VL 29 IS 11 SI SI BP A83 EP A83 PG 1 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA 239PI UT WOS:000326037500209 ER PT J AU Karasavvas, N Karnasuta, C de Souza, MS Madnote, S Inthawong, D Savadsuk, H Rittiroongrad, S Chantakulkij, S Nitayaphan, S Pitisuttithum, P Thongcharoen, P Siriyanon, V Andrews, CA O'Connell, RJ Michael, NL Ngauy, V Kim, JH AF Karasavvas, N. Karnasuta, C. de Souza, M. S. Madnote, S. Inthawong, D. Savadsuk, H. Rittiroongrad, S. Chantakulkij, S. Nitayaphan, S. Pitisuttithum, P. Thongcharoen, P. Siriyanon, V. Andrews, C. A. O'Connell, R. J. Michael, N. L. Ngauy, V. Kim, J. H. TI Antibody Responses to Recombinant gp120, gp70 V1V2 Proteins and Cyclic V2 Peptide in Thai Phase I/II Vaccine Trials Using Different Vaccine Regimens SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Meeting Abstract CT Conference on AIDS Vaccine CY OCT 07-10, 2013 CL Barcelona, SPAIN C1 [Karasavvas, N.; Karnasuta, C.; Madnote, S.; Inthawong, D.; Savadsuk, H.; Rittiroongrad, S.; Chantakulkij, S.; Ngauy, V.] USAMC AFRIMS, Bangkok, Thailand. [de Souza, M. S.] TRCARC, Southeast Asian Res Collaborat Univ Hawaii SEARCH, Bangkok, Thailand. [Nitayaphan, S.] Royal Thai Army Armed Forces Res Inst Med Sci RTA, Bangkok, Thailand. [Pitisuttithum, P.] Mahidol Univ, Bangkok 10700, Thailand. [Thongcharoen, P.] Mahidol Univ, Siriraj Hosp, Bangkok 10700, Thailand. [Siriyanon, V.] Chiang Mai Univ, Chiangmai, Thailand. [Andrews, C. A.; O'Connell, R. J.; Michael, N. L.; Kim, J. H.] Walter Reed Army Inst Res, US Mil HIV Res Program MHRP, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0889-2229 EI 1931-8405 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD NOV 1 PY 2013 VL 29 IS 11 SI SI BP A50 EP A50 PG 1 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA 239PI UT WOS:000326037500122 ER PT J AU Krebs, SJ Narpala, S Wheatley, A Slike, BM Eller, M Ratto-Kim, S Polonis, VR Kim, JH Robb, ML Marovich, MA Koup, RA Graham, BS Michael, NL McDermott, A AF Krebs, S. J. Narpala, S. Wheatley, A. Slike, B. M. Eller, M. Ratto-Kim, S. Polonis, V. R. Kim, J. H. Robb, M. L. Marovich, M. A. Koup, R. A. Graham, B. S. Michael, N. L. McDermott, A. TI Comparative Analysis of Binding Antibody Responses Elicited by a Cross-Section of Human HIV-1 Vaccine Clinical Trials SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Meeting Abstract CT Conference on AIDS Vaccine CY OCT 07-10, 2013 CL Barcelona, SPAIN C1 [Krebs, S. J.; Slike, B. M.; Eller, M.; Ratto-Kim, S.; Polonis, V. R.; Kim, J. H.; Robb, M. L.; Marovich, M. A.; Michael, N. L.] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD USA. [Krebs, S. J.; Slike, B. M.; Eller, M.; Ratto-Kim, S.; Robb, M. L.] Henry M Jackson Fdn Adv Mil Med, Silver Spring, MD USA. [Narpala, S.; Wheatley, A.; Koup, R. A.; Graham, B. S.; McDermott, A.] NIAID, Vaccine Res Ctr, NIH, Bethesda, MD 20892 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0889-2229 EI 1931-8405 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD NOV 1 PY 2013 VL 29 IS 11 SI SI BP A8 EP A9 PG 2 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA 239PI UT WOS:000326037500014 ER PT J AU Li, SS Gilbert, PB Tomaras, GD Kijak, G Ferrari, G Thomas, R Zolla-Pazner, S Evans, DT Li, Y Gottardo, R Dai, JY Janes, H Morris, D Fong, Y Edlefsen, PT Li, F Magaret, CA Frahm, N Alpert, MD Rerks-Ngarm, S Pitisuttithum, P Kaewkungwal, J Nitayaphan, S Robb, ML O'Connell, RJ Michael, NL Kim, JH McElrath, MJ Geraghty, DE AF Li, S. S. Gilbert, P. B. Tomaras, G. D. Kijak, G. Ferrari, G. Thomas, R. Zolla-Pazner, S. Evans, D. T. Li, Y. Gottardo, R. Dai, J. Y. Janes, H. Morris, D. Fong, Y. Edlefsen, P. T. Li, F. Magaret, C. A. Frahm, N. Alpert, M. D. Rerks-Ngarm, S. Pitisuttithum, P. Kaewkungwal, J. Nitayaphan, S. Robb, M. L. O'Connell, R. J. Michael, N. L. Kim, J. H. McElrath, M. J. Geraghty, D. E. TI Association of Fc gamma RIIC Polymorphism with Vaccine Efficacy and Correlates of HIV-1 Infection Risk in RV144 SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Meeting Abstract CT Conference on AIDS Vaccine CY OCT 07-10, 2013 CL Barcelona, SPAIN C1 [Li, S. S.; Gilbert, P. B.; Li, Y.; Gottardo, R.; Dai, J. Y.; Janes, H.; Morris, D.; Fong, Y.; Edlefsen, P. T.; Li, F.; Magaret, C. A.; Frahm, N.; McElrath, M. J.; Geraghty, D. E.] Fred Hutchinson Canc Res Ctr, Seattle, WA 98104 USA. [Tomaras, G. D.; Ferrari, G.] Duke Univ, Sch Med, Durham, NC USA. [Kijak, G.; Thomas, R.; Robb, M. L.; O'Connell, R. J.; Michael, N. L.; Kim, J. H.] US MRHP, Silver Spring, MD USA. [Zolla-Pazner, S.] Vet Affairs New York Harbor Healthcare Syst, New York, NY USA. [Zolla-Pazner, S.] NYU, Sch Med, New York, NY USA. [Evans, D. T.] Univ Wisconsin, Madison, WI USA. [Alpert, M. D.] Harvard Univ, Sch Med, Southborough, MA 01772 USA. [Rerks-Ngarm, S.] Minist Publ Hlth, Nonthaburi, Thailand. [Pitisuttithum, P.; Kaewkungwal, J.] Mahidol Univ, Bangkok 10700, Thailand. [Nitayaphan, S.] Royal Thai Army, Armed Forces Res Inst Med Sci, Bangkok, Thailand. RI Tomaras, Georgia/J-5041-2016 NR 0 TC 0 Z9 0 U1 0 U2 3 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0889-2229 EI 1931-8405 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD NOV 1 PY 2013 VL 29 IS 11 SI SI BP A178 EP A179 PG 2 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA 239PI UT WOS:000326037500467 ER PT J AU Limwattanayingyong, A Arun-Ngamwong, T Wattanakitwichai, J Yamoon, D Debyasuvarn, T Dhitarat, J Kaewkungwal, J Namwat, C Premsri, N Churikanont, N Excler, J O'Connell, R Eamsila, C Kim, J Karasavvas, N Vasan, S Ngauy, V Pitisuttithum, P Rerks-Ngarm, S AF Limwattanayingyong, A. Arun-Ngamwong, T. Wattanakitwichai, J. Yamoon, D. Debyasuvarn, T. Dhitarat, J. Kaewkungwal, J. Namwat, C. Premsri, N. Churikanont, N. Excler, J. O'Connell, R. Eamsila, C. Kim, J. Karasavvas, N. Vasan, S. Ngauy, V. Pitisuttithum, P. Rerks-Ngarm, S. TI Acceptability and Quality of New Mucosal Secretion Collection Procedures in an HIV Vaccine Trial in Thailand SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Meeting Abstract CT Conference on AIDS Vaccine CY OCT 07-10, 2013 CL Barcelona, SPAIN C1 [Limwattanayingyong, A.] HIV Vaccine Trial Ctr, Bangkok, Thailand. [Arun-Ngamwong, T.; Yamoon, D.] Banglamung Hosp, Chon Buri, Thailand. [Wattanakitwichai, J.; Dhitarat, J.; Pitisuttithum, P.] Mahidol Univ, Bangkok 10700, Thailand. [Debyasuvarn, T.; Namwat, C.; Rerks-Ngarm, S.] Minist Publ Hlth, Nonthaburi, Thailand. [Kaewkungwal, J.] Mahidol Univ, BIOPHICS, Bangkok 10700, Thailand. [Premsri, N.; Churikanont, N.; O'Connell, R.; Eamsila, C.; Kim, J.; Karasavvas, N.; Ngauy, V.] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Excler, J.] Henry M Jackson Fdn, US Mil HIV Res Program, Bethesda, MD USA. [Vasan, S.] Henry M Jackson Fdn, Armed Forces Res Inst Med Sci, Bangkok, Thailand. NR 0 TC 0 Z9 0 U1 0 U2 2 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0889-2229 EI 1931-8405 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD NOV 1 PY 2013 VL 29 IS 11 SI SI BP A66 EP A66 PG 1 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA 239PI UT WOS:000326037500164 ER PT J AU Liyanage, NP Gordon, SN Vaccari, M Pegu, P Doster, MN Tomaras, GD Venzon, D Stablien, D Tartaglia, J Barnett, SW Kim, JH Michael, NL Franchini, G AF Liyanage, N. P. Gordon, S. N. Vaccari, M. Pegu, P. Doster, M. N. Tomaras, G. D. Venzon, D. Stablien, D. Tartaglia, J. Barnett, S. W. Kim, J. H. Michael, N. L. Franchini, G. TI Alum and MF59, in Combination with ALVAC-SIV and Gp120 Vaccines Recruit Functionally Different NK Cells to the Gut of Vaccinated Rhesus Macaque SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Meeting Abstract CT Conference on AIDS Vaccine CY OCT 07-10, 2013 CL Barcelona, SPAIN C1 [Liyanage, N. P.; Gordon, S. N.; Vaccari, M.; Pegu, P.; Doster, M. N.; Franchini, G.] NCI, Bethesda, MD 20892 USA. [Tomaras, G. D.] Duke Human Vaccine Inst, Durham, NC USA. [Venzon, D.] NCI, NIH, Bethesda, MD 20892 USA. [Stablien, D.] EMMES Corp, Rockville, MD USA. [Tartaglia, J.] Sanofi Pasteur, Swiftwater, PA USA. [Barnett, S. W.] Novartis Vaccines & Diagnost Inc, Cambridge, MA USA. [Kim, J. H.; Michael, N. L.] Walter Reed Army Inst Res, Silver Spring, MD USA. RI Tomaras, Georgia/J-5041-2016 NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0889-2229 EI 1931-8405 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD NOV 1 PY 2013 VL 29 IS 11 SI SI BP A100 EP A100 PG 1 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA 239PI UT WOS:000326037500255 ER PT J AU Mahan, A Tedesco, J Dionne, K Chung, A Cox, J Koff, W Barouch, D Michael, N Kim, J Suscovich, T Alter, G AF Mahan, A. Tedesco, J. Dionne, K. Chung, A. Cox, J. Koff, W. Barouch, D. Michael, N. Kim, J. Suscovich, T. Alter, G. TI Antibody Glycosylation Can Be Transiently Altered After Vaccination Against HIV SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Meeting Abstract CT Conference on AIDS Vaccine CY OCT 07-10, 2013 CL Barcelona, SPAIN C1 [Mahan, A.; Tedesco, J.; Dionne, K.; Chung, A.; Suscovich, T.; Alter, G.] Ragon Inst MGH MIT & Harvard, Cambridge, MA USA. [Cox, J.; Koff, W.] IAVI, New York, NY USA. [Barouch, D.] Beth Israel Deaconess Med Ctr, Boston, MA 02215 USA. [Michael, N.; Kim, J.] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0889-2229 EI 1931-8405 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD NOV 1 PY 2013 VL 29 IS 11 SI SI BP A47 EP A47 PG 1 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA 239PI UT WOS:000326037500113 ER PT J AU Mann, P Kosgei, J Sekiziyivu, A Sawe, F Maboko, L Kibuuka, H Tong, T Karasavva, N Robb, M Eller, L Ake, J Marovich, M Ngauy, V AF Mann, P. Kosgei, J. Sekiziyivu, A. Sawe, F. Maboko, L. Kibuuka, H. Tong, T. Karasavva, N. Robb, M. Eller, L. Ake, J. Marovich, M. Ngauy, V. TI Acceptability and Tolerability of Novel Mucosal Secretion Collection Methods in an HIV Vaccine Trial in East Africa SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Meeting Abstract CT Conference on AIDS Vaccine CY OCT 07-10, 2013 CL Barcelona, SPAIN C1 [Mann, P.; Maboko, L.] Natl Inst Med Res, Mbeya Med Res Ctr, Mbeya, Tanzania. [Kosgei, J.; Sawe, F.] Kenya Govt Med Res Ctr, Walter Reed Project, Kericho, Kenya. [Sekiziyivu, A.; Kibuuka, H.] Makerere Univ, Walter Reed Project, Kampala, Uganda. [Tong, T.; Robb, M.; Eller, L.; Ake, J.] US Mil HIV Res Program, Rockville, MD USA. [Karasavva, N.; Ngauy, V.] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Marovich, M.] NIAID, Div Aids, NIH, Bethesda, MD 20892 USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0889-2229 EI 1931-8405 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD NOV 1 PY 2013 VL 29 IS 11 SI SI BP A142 EP A142 PG 1 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA 239PI UT WOS:000326037500371 ER PT J AU Matyas, GR Rao, M Tucker, C Kalyanaraman, V Whitney, S VanCott, T Michael, NL Robb, ML Polonis, V Alving, CR AF Matyas, G. R. Rao, M. Tucker, C. Kalyanaraman, V. Whitney, S. VanCott, T. Michael, N. L. Robb, M. L. Polonis, V. Alving, C. R. TI Stability of an Acute HIV-1 Tanzanian Subtype C gp145 Envelope Protein for Clinical Development SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Meeting Abstract CT Conference on AIDS Vaccine CY OCT 07-10, 2013 CL Barcelona, SPAIN C1 [Matyas, G. R.; Rao, M.; Michael, N. L.; Polonis, V.; Alving, C. R.] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD USA. [Tucker, C.; Robb, M. L.] Henry M Jackson Fdn Adv Mil Med, US Mil HIV Res Program, Bethesda, MD USA. [Kalyanaraman, V.; Whitney, S.; VanCott, T.] Adv Biosci Labs Inc, Rockville, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0889-2229 EI 1931-8405 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD NOV 1 PY 2013 VL 29 IS 11 SI SI BP A29 EP A30 PG 2 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA 239PI UT WOS:000326037500065 ER PT J AU Pollara, J Bonsignori, M Moody, M Alam, S Hwang, K Gurley, TC Kozink, DM Marshall, DJ Whitesides, JF Tsao, C Kaewkungwal, J Nitayaphan, S Pitisuttithum, P Rerks-Ngarm, S Tomaras, GD Kim, JH Michael, NL Montefiori, DC Liao, H Haynes, BF Ferrari, G AF Pollara, J. Bonsignori, M. Moody, M. Alam, S. Hwang, K. Gurley, T. C. Kozink, D. M. Marshall, D. J. Whitesides, J. F. Tsao, C. Kaewkungwal, J. Nitayaphan, S. Pitisuttithum, P. Rerks-Ngarm, S. Tomaras, G. D. Kim, J. H. Michael, N. L. Montefiori, D. C. Liao, H. Haynes, B. F. Ferrari, G. CA Ctr HIV AIDS Vaccine Immunology TI Heterogeneity of Anti-V2 ADCC Ab Responses and Implications for Vaccine Development SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Meeting Abstract CT Conference on AIDS Vaccine CY OCT 07-10, 2013 CL Barcelona, SPAIN C1 [Pollara, J.; Bonsignori, M.; Moody, M.; Alam, S.; Hwang, K.; Gurley, T. C.; Kozink, D. M.; Marshall, D. J.; Whitesides, J. F.; Tsao, C.; Tomaras, G. D.; Montefiori, D. C.; Liao, H.; Haynes, B. F.; Ferrari, G.; Ctr HIV AIDS Vaccine Immunology] Duke Univ, Durham, NC USA. [Kaewkungwal, J.; Pitisuttithum, P.] Mahidol Univ, Bangkok 10700, Thailand. [Nitayaphan, S.] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Kim, J. H.; Michael, N. L.] US Mil HIV Res Program, Silver Spring, MD USA. RI Tomaras, Georgia/J-5041-2016 NR 0 TC 0 Z9 0 U1 0 U2 2 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0889-2229 EI 1931-8405 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD NOV 1 PY 2013 VL 29 IS 11 SI SI BP A41 EP A41 PG 1 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA 239PI UT WOS:000326037500096 ER PT J AU Prentice, H Geraghty, DE Tomaras, GD Fong, Y Nelson, W Kijak, GH Zolla-Pazner, S Nitayaphan, S Rerks-Ngarm, S Kaewkungwal, J Pitisuttithum, P Gilbert, PB Haynes, BF Kim, JH Michael, N Thomas, R AF Prentice, H. Geraghty, D. E. Tomaras, G. D. Fong, Y. Nelson, W. Kijak, G. H. Zolla-Pazner, S. Nitayaphan, S. Rerks-Ngarm, S. Kaewkungwal, J. Pitisuttithum, P. Gilbert, P. B. Haynes, B. F. Kim, J. H. Michael, N. Thomas, R. TI HLA Class II Genes Interact with the Immune Correlates from the RV144 Vaccine Efficacy Trial and Impact HIV-1 Acquisition SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Meeting Abstract CT Conference on AIDS Vaccine CY OCT 07-10, 2013 CL Barcelona, SPAIN C1 [Geraghty, D. E.; Fong, Y.; Nelson, W.; Gilbert, P. B.] Fred Hutchinson Canc Res Ctr, Seattle, WA 98104 USA. [Tomaras, G. D.; Haynes, B. F.] Duke Univ, Sch Med, Durham, NC USA. [Zolla-Pazner, S.] NYU, Sch Med, New York, NY USA. [Nitayaphan, S.] US Army Med Component, AFRIMS, Bangkok, Thailand. [Rerks-Ngarm, S.] Minist Publ Hlth, Nonthanburi, Thailand. [Kaewkungwal, J.; Pitisuttithum, P.] Mahidol Univ, Bangkok 10700, Thailand. [Prentice, H.; Kijak, G. H.; Kim, J. H.] US MHRP, Silver Spring, MD USA. RI Tomaras, Georgia/J-5041-2016 NR 0 TC 0 Z9 0 U1 0 U2 2 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0889-2229 EI 1931-8405 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD NOV 1 PY 2013 VL 29 IS 11 SI SI BP A178 EP A178 PG 1 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA 239PI UT WOS:000326037500466 ER PT J AU Rutvisuttinunt, W Chantakulkij, S Gioia, CJ McRaven, M Rittiroongrad, S Karnasuta, C Cianci, GC Michael, NL Ngauy, V de Souza, M Kim, J Hope, TJ Karasavvas, N AF Rutvisuttinunt, W. Chantakulkij, S. Gioia, C. J. McRaven, M. Rittiroongrad, S. Karnasuta, C. Cianci, G. C. Michael, N. L. Ngauy, V. de Souza, M. Kim, J. Hope, T. J. Karasavvas, N. TI Qualification of the Particle Diffusion Assay for Single Particle Tracking SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Meeting Abstract CT Conference on AIDS Vaccine CY OCT 07-10, 2013 CL Barcelona, SPAIN C1 [Rutvisuttinunt, W.; Chantakulkij, S.; Rittiroongrad, S.; Karnasuta, C.; Ngauy, V.; Karasavvas, N.] AFRIMS, Bangkok, Thailand. [Gioia, C. J.; McRaven, M.; Cianci, G. C.; Hope, T. J.] Northwestern Univ, Feinberg Sch Med, Chicago, IL 60611 USA. [Michael, N. L.; Kim, J.] Walter Reed Army Inst Res, US Mil Res Program, Silver Spring, MD USA. [de Souza, M.] Thai Red Cross AIDS Res Ctr, SEARCH, Bangkok, Thailand. NR 0 TC 0 Z9 0 U1 0 U2 1 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0889-2229 EI 1931-8405 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD NOV 1 PY 2013 VL 29 IS 11 SI SI BP A108 EP A108 PG 1 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA 239PI UT WOS:000326037500276 ER PT J AU Schifanella, L Gordon, S Vaccari, M Binello, N Caccuri, F Blackburn, M Fenizia, C Doster, M Pegu, P Liynage, N Shen, X Tomaras, G Rao, M Ferrari, G Venzon, D Stablien, D Barnett, S Tartaglia, J Franchini, G AF Schifanella, L. Gordon, S. Vaccari, M. Binello, N. Caccuri, F. Blackburn, M. Fenizia, C. Doster, M. Pegu, P. Liynage, N. Shen, X. Tomaras, G. Rao, M. Ferrari, G. Venzon, D. Stablien, D. Barnett, S. Tartaglia, J. Franchini, G. TI MF59 and ALUM, in Combination with an ALVAC-SIV/gp120 Vaccine, Induce Plasmablasts that Differ in the Expression of Homing Markers SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Meeting Abstract CT Conference on AIDS Vaccine CY OCT 07-10, 2013 CL Barcelona, SPAIN C1 [Schifanella, L.; Gordon, S.; Vaccari, M.; Binello, N.; Caccuri, F.; Blackburn, M.; Fenizia, C.; Doster, M.; Pegu, P.; Liynage, N.; Venzon, D.; Franchini, G.] NCI, NIH, Bethesda, MD 20892 USA. [Shen, X.; Tomaras, G.] Duke Human Vaccine Inst, Durham, NC USA. [Rao, M.] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD USA. [Ferrari, G.] Duke Univ, Med Ctr, Durham, NC USA. [Stablien, D.] EMMES Corp, Rockville, MD USA. [Barnett, S.] Novartis Vaccines & Diagnost Inc, Cambridge, MA USA. [Tartaglia, J.] Sanofi Pasteur, Swiftwater, PA USA. RI Tomaras, Georgia/J-5041-2016 NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0889-2229 EI 1931-8405 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD NOV 1 PY 2013 VL 29 IS 11 SI SI BP A13 EP A13 PG 1 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA 239PI UT WOS:000326037500026 ER PT J AU Shen, X Howington, R Park, H Sadagopal, S Kwa, S Cope, A Ding, S Bolton, D Roederer, M Amara, R Picker, L Seder, R McElrath, J Barnett, S Shattock, R Felber, B Pavlakis, G Pantaleo, G Montefiori, D Tomaras, G AF Shen, X. Howington, R. Park, H. Sadagopal, S. Kwa, S. Cope, A. Ding, S. Bolton, D. Roederer, M. Amara, R. Picker, L. Seder, R. McElrath, J. Barnett, S. Shattock, R. Felber, B. Pavlakis, G. Pantaleo, G. Montefiori, D. Tomaras, G. TI Vaccine Induced Epitope Specific Antibodies to the SIV Envelope Are Distinct from Those Induced to the HIV-1 Envelope SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Meeting Abstract CT Conference on AIDS Vaccine CY OCT 07-10, 2013 CL Barcelona, SPAIN C1 [Shen, X.; Howington, R.; Montefiori, D.; Tomaras, G.] Duke Univ, Durham, NC USA. [Park, H.; Picker, L.] Oregon Hlth & Sci Univ, Beaverton, OR USA. [Sadagopal, S.; Amara, R.] Emory Univ, Atlanta, GA 30322 USA. [Kwa, S.] GeoVax Inc, Smyrna, GA USA. [Cope, A.; Shattock, R.] Univ London Imperial Coll Sci Technol & Med, London, England. [Ding, S.] EuroVacc Fdn, Amsterdam, Netherlands. [Bolton, D.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Roederer, M.; Seder, R.] NIAID, NIH, Bethesda, MD 20892 USA. [McElrath, J.] Univ Washington, Seattle, WA 98195 USA. [Barnett, S.] Novartis Vaccines & Diagnost Inc, Cambridge, MA USA. [Felber, B.; Pavlakis, G.] NCI, Frederick, MD 21701 USA. [Pantaleo, G.] Univ Lausanne, Lausanne, Switzerland. RI Tomaras, Georgia/J-5041-2016; Pantaleo, Giuseppe/K-6163-2016 NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0889-2229 EI 1931-8405 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD NOV 1 PY 2013 VL 29 IS 11 SI SI BP A10 EP A11 PG 2 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA 239PI UT WOS:000326037500019 ER PT J AU Tassaneetrithep, B Tivon, D Swetnam, J Kim, JH Michael, NL Marovich, MA Cardozo, T AF Tassaneetrithep, B. Tivon, D. Swetnam, J. Kim, J. H. Michael, N. L. Marovich, M. A. Cardozo, T. TI Cryptic Determinant of alpha 4 beta 7 Binding in the V2 Loop of HIV-1 SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Meeting Abstract CT Conference on AIDS Vaccine CY OCT 07-10, 2013 CL Barcelona, SPAIN C1 [Tassaneetrithep, B.; Kim, J. H.; Michael, N. L.; Marovich, M. A.] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD USA. [Tivon, D.; Swetnam, J.; Cardozo, T.] NYU, Sch Med, New York, NY USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0889-2229 EI 1931-8405 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD NOV 1 PY 2013 VL 29 IS 11 SI SI BP A79 EP A79 PG 1 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA 239PI UT WOS:000326037500199 ER PT J AU Vaccari, M Gordon, SN Doster, M Liynage, N Pegu, P Schifanella, L Keele, BF Shen, X Tomaras, GD Rao, M Montefiori, DC Ferrari, G Foulds, K Roederer, M Venzon, D Stablein, DM Kim, JH Michael, NL Phogat, S Barnett, SW Tartaglia, J Franchini, G AF Vaccari, M. Gordon, S. N. Doster, M. Liynage, N. Pegu, P. Schifanella, L. Keele, B. F. Shen, X. Tomaras, G. D. Rao, M. Montefiori, D. C. Ferrari, G. Foulds, K. Roederer, M. Venzon, D. Stablein, D. M. Kim, J. H. Michael, N. L. Phogat, S. Barnett, S. W. Tartaglia, J. Franchini, G. TI Protection from SIVmac251 Acquisition by an ALVAC/SIV/gp120 Regimen Is Not Improved by the Increase of Anti-Envelope Antibodies and T Cell Responses SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Meeting Abstract CT Conference on AIDS Vaccine CY OCT 07-10, 2013 CL Barcelona, SPAIN C1 [Vaccari, M.; Gordon, S. N.; Doster, M.; Liynage, N.; Pegu, P.; Schifanella, L.; Venzon, D.; Franchini, G.] NCI, NIH, Bethesda, MD 20892 USA. [Keele, B. F.] Natl Canc Inst, SAIC Frederick, Frederick, MD USA. [Shen, X.; Tomaras, G. D.] Duke Human Vaccine Inst, Durham, NC USA. [Rao, M.] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD USA. [Montefiori, D. C.; Ferrari, G.] Duke Univ, Med Ctr, Durham, NC USA. [Foulds, K.; Roederer, M.] NIH, Bethesda, MD 20892 USA. [Stablein, D. M.] EMMES Corp, Rockville, MD USA. [Kim, J. H.; Michael, N. L.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Phogat, S.; Tartaglia, J.] Sanofi Pasteur, Swiftwater, PA USA. [Barnett, S. W.] Novartis Vaccines & Diagnost, Cambridge, MA USA. RI Tomaras, Georgia/J-5041-2016 NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0889-2229 EI 1931-8405 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD NOV 1 PY 2013 VL 29 IS 11 SI SI BP A34 EP A34 PG 1 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA 239PI UT WOS:000326037500078 ER PT J AU Wieczorek, L Krebs, S Kalyanaraman, V Whitney, S Matyas, GR Rao, M Alving, CR Tong, T Molnar, S Wesberry, M Chenine, AL Tovanabutra, S Sanders-Buell, E Slike, B Alam, S Liao, H Haynes, BF Williams, C Zolla-Pazner, S Moscoso, C Cheng, H Hoelscher, M Maboko, L Michael, N Robb, ML VanCott, T Marovich, M Polonis, V AF Wieczorek, L. Krebs, S. Kalyanaraman, V. Whitney, S. Matyas, G. R. Rao, M. Alving, C. R. Tong, T. Molnar, S. Wesberry, M. Chenine, A. Laurence Tovanabutra, S. Sanders-Buell, E. Slike, B. Alam, S. Liao, H. Haynes, B. F. Williams, C. Zolla-Pazner, S. Moscoso, C. Cheng, H. Hoelscher, M. Maboko, L. Michael, N. Robb, M. L. VanCott, T. Marovich, M. Polonis, V. TI Comparable Antigenicity and Immunogenicity of Multimeric Forms of a Novel, Acute HIV-1 Subtype C Gp145 Envelope for Clinical Development SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Meeting Abstract CT Conference on AIDS Vaccine CY OCT 07-10, 2013 CL Barcelona, SPAIN C1 [Wieczorek, L.; Krebs, S.; Matyas, G. R.; Rao, M.; Alving, C. R.; Tong, T.; Molnar, S.; Wesberry, M.; Chenine, A. Laurence; Tovanabutra, S.; Sanders-Buell, E.; Slike, B.; Michael, N.; Robb, M. L.; Polonis, V.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Wieczorek, L.; Krebs, S.; Tong, T.; Molnar, S.; Wesberry, M.; Chenine, A. Laurence; Tovanabutra, S.; Sanders-Buell, E.; Slike, B.; Robb, M. L.] Henry M Jackson Fdn, Silver Spring, MD USA. [Kalyanaraman, V.; Whitney, S.; VanCott, T.] Adv Biosci Labs Inc, Rockville, MD USA. [Matyas, G. R.; Rao, M.; Alving, C. R.; Michael, N.; Marovich, M.; Polonis, V.] US Mil HIV Res Program, Silver Spring, MD USA. [Alam, S.; Liao, H.; Haynes, B. F.] Duke Univ, Durham, NC USA. [Williams, C.; Zolla-Pazner, S.] Vet Affairs New York Harbor Healthcare Syst, New York, NY USA. [Williams, C.; Zolla-Pazner, S.] NYU, Sch Med, New York, NY USA. [Moscoso, C.; Cheng, H.] Univ Calif Davis, Davis, CA 95616 USA. [Hoelscher, M.; Maboko, L.] Mbeya Med Res Project, Munich, Germany. [Hoelscher, M.; Maboko, L.] Univ Munich, Munich, Germany. [Marovich, M.] NIH DAIDS, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0889-2229 EI 1931-8405 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD NOV 1 PY 2013 VL 29 IS 11 SI SI BP A30 EP A30 PG 1 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA 239PI UT WOS:000326037500066 ER PT J AU Wiehe, K Easterhoff, D Luo, K Williams, W Vandergrift, N Lloyd, E Stolarchuk, C Parks, R Nicely, N Kaewkungwal, J Nitayaphan, S Pitisuttithum, P Rerks-Ngarm, S Michael, N Kim, J Tomaras, G Bonsignori, M Kepler, TB Moody, AM Liao, H Haynes, BF AF Wiehe, K. Easterhoff, D. Luo, K. Williams, W. Vandergrift, N. Lloyd, E. Stolarchuk, C. Parks, R. Nicely, N. Kaewkungwal, J. Nitayaphan, S. Pitisuttithum, P. Rerks-Ngarm, S. Michael, N. Kim, J. Tomaras, G. Bonsignori, M. Kepler, T. B. Moody, A. M. Liao, H. Haynes, B. F. TI Phylogenetic Conservation of a Dominant Antibody Light Chain HIV Env V2 Binding Motif in Human and rhesus Macaque Antibodies SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Meeting Abstract CT Conference on AIDS Vaccine CY OCT 07-10, 2013 CL Barcelona, SPAIN C1 [Wiehe, K.] Duke Univ, Med Ctr, Durham, NC USA. [Easterhoff, D.; Luo, K.; Williams, W.; Vandergrift, N.; Lloyd, E.; Stolarchuk, C.; Parks, R.; Nicely, N.; Tomaras, G.; Bonsignori, M.; Moody, A. M.; Liao, H.; Haynes, B. F.] Duke Univ, Sch Med, Durham, NC USA. [Kaewkungwal, J.; Pitisuttithum, P.] Mahidol Univ, Bangkok 10700, Thailand. [Nitayaphan, S.] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Rerks-Ngarm, S.] Minist Publ Hlth, Nonthaburi, Thailand. [Michael, N.; Kim, J.] US MHRP, Silver Spring, MD USA. [Kepler, T. B.] Boston Univ, Sch Med, Boston, MA 02118 USA. RI Tomaras, Georgia/J-5041-2016 NR 0 TC 0 Z9 0 U1 0 U2 1 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0889-2229 EI 1931-8405 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD NOV 1 PY 2013 VL 29 IS 11 SI SI BP A168 EP A168 PG 1 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA 239PI UT WOS:000326037500439 ER PT J AU Sherali, HD Lunday, BJ AF Sherali, Hanif D. Lunday, Brian J. TI On generating maximal nondominated Benders cuts SO ANNALS OF OPERATIONS RESEARCH LA English DT Article DE Benders decomposition; Maximal cuts; Nondominated cuts; Pareto-optimal cuts ID NETWORK DESIGN; DECOMPOSITION; MODEL AB In this paper, we explore certain algorithmic strategies for accelerating the convergence of Benders decomposition method via the generation of maximal nondominated cuts. Based on interpreting the seminal work of Magnanti and Wong (Operations Research, 29(3), 464-484, 1981) for generating nondominated cuts within a multiobjective framework, we propose an algorithmic strategy that utilizes a preemptively small perturbation of the right-hand-side of the Benders subproblem to generate maximal nondominated Benders cuts, as well as a complimentary strategy that generates an additional cut in each iteration via an alternative emphasis on decision variable weights. We also examine the computational effectiveness of solving a secondary subproblem using an objective cut as proposed by Magnanti and Wong versus identifying the Pareto-optimality region for cut generation by utilizing complementary slackness conditions. In addition, we exhibit how a standard feasibility cut can be extracted from the solution of subproblems that generate only optimality cuts through the use of artificial variables. With Magnanti and Wong's baseline procedure approximated during implementation via the use of a core point estimation technique (Papadakos in Computers and Operations Research, 36(1), 176-195, 2009), these algorithmic strategies are tested on instances from the literature concerning the fixed charge network flow program. C1 [Sherali, Hanif D.] Virginia Tech, Grado Dept Ind & Syst Engn, Blacksburg, VA 24061 USA. [Lunday, Brian J.] US Mil Acad, Dept Math Sci, West Point, NY 10996 USA. RP Lunday, BJ (reprint author), US Mil Acad, Dept Math Sci, West Point, NY 10996 USA. EM hanifs@vt.edu; brian.lunday@usma.edu OI Lunday, Brian/0000-0001-5191-4361 FU National Science Foundation [CMMI-0969169] FX This work is partially supported by the National Science Foundation under Grant No. CMMI-0969169. The authors also thank the Guest Editor and four referees for their detailed and constructive comments that have greatly helped improve the presentation of this paper. NR 30 TC 10 Z9 10 U1 0 U2 8 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0254-5330 EI 1572-9338 J9 ANN OPER RES JI Ann. Oper. Res. PD NOV PY 2013 VL 210 IS 1 BP 57 EP 72 DI 10.1007/s10479-011-0883-6 PG 16 WC Operations Research & Management Science SC Operations Research & Management Science GA 242YK UT WOS:000326282300004 ER PT J AU Fernandez, S Cisney, ED Ulrich, RG AF Fernandez, Stefan Cisney, Emily D. Ulrich, Robert G. TI Enhancement of Serum and Mucosal Immune Responses to a Haemophilus influenzae Type B Vaccine by Intranasal Delivery SO CLINICAL AND VACCINE IMMUNOLOGY LA English DT Article ID POLYSACCHARIDE CONJUGATE VACCINES; LYMPHOID-TISSUE NALT; REGIONAL SPECIALIZATION; CUTTING EDGE; IMMUNIZATION; ANTIBODY; CHILDREN; MODEL; IMMUNOGENICITY; STREPTOCOCCUS AB Intranasal (i.n.) vaccination is potentially the most direct method for conveying upper respiratory and mucosal immunity to respiratory pathogens. However, for unclear reasons, vaccines introduced into the nasal sinuses often have lower efficacy than vaccines administered by the more frequently used parenteral routes. We examined i.n. vaccination in a mouse immune-response model with a commonly used Haemophilus influenzae type B vaccine (Hibv) composed of the polyribosylribitol phosphate (PRP) capsule antigen conjugated to tetanus toxoid. Intranasal vaccination with Hibv using a Toll-like receptor 4 (TLR4) agonist as an adjuvant significantly increased the levels of IgA specific for the PRP capsule antigen in blood serum, saliva, and mucosal secretion specimens. In contrast, control mice vaccinated transdermally (t.d.) with Hibv did not produce significant levels of PRP-specific IgA in the blood serum and saliva, and anti-PRP IgG was increased only in serum. The i.n. and t.d. vaccinations resulted in equivalent bactericidal antibody responses in blood serum, suggesting that vaccine-derived IgG is protective against infection. Elevated levels of IgG specific for the tetanus toxoid carrier protein were measured in nasal sinuses and vaginal secretions in mice vaccinated by either the t.d. or i.n. route. Tissue culture studies confirmed that the nasopharynx-associated lymphoid tissue (NALT) was at least one of the sources of PRP-specific IgA and carrier-specific IgG within the nasal sinuses. We conclude that i.n. vaccination aided by a TLR4 agonist results in robust immune responses to both the carrier protein and bacterial polysaccharide components of the Hibv. C1 [Fernandez, Stefan; Cisney, Emily D.; Ulrich, Robert G.] US Army, Med Res Inst Infect Dis, Frederick, MD USA. RP Fernandez, S (reprint author), US Army, Med Res Inst Infect Dis, Frederick, MD USA. EM stefan.fernandez@afrims.org; rulrich@bhsai.org FU U.S. Department of Energy; USMRMC FX This project was supported in part by an appointment of E. D. C. to the Research Participation Program for the U. S. Army Medical Research and Materiel Command (USMRMC), administered by the Oak Ridge Institute for Science and Education through an agreement between the U.S. Department of Energy and the USMRMC. NR 52 TC 3 Z9 3 U1 1 U2 6 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 1556-6811 EI 1556-679X J9 CLIN VACCINE IMMUNOL JI Clin. Vaccine Immunol. PD NOV PY 2013 VL 20 IS 11 BP 1690 EP 1696 DI 10.1128/CVI.00215-13 PG 7 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 241KI UT WOS:000326165300005 PM 23986319 ER PT J AU Veitch, DP Friedl, KE Weiner, MW AF Veitch, Dallas P. Friedl, Karl E. Weiner, Michael W. TI Military Risk Factors for Cognitive Decline, Dementia and Alzheimer's Disease SO CURRENT ALZHEIMER RESEARCH LA English DT Article DE Alzheimer's disease; armed forces; combat; depression; gulf war illness; post-traumatic stress disorder; risk factors; traumatic brain injury ID POSTTRAUMATIC-STRESS-DISORDER; TRAUMATIC BRAIN-INJURY; GULF-WAR VETERANS; MENTAL-HEALTH PROBLEMS; QUALITY-OF-LIFE; PERSISTENT ORGANIC POLLUTANTS; AMYLOID PROTEIN DEPOSITION; MAJOR DEPRESSIVE DISORDER; CORONARY-HEART-DISEASE; CHRONIC KIDNEY-DISEASE AB Delayed neurological health consequences of environmental exposures during military service have been generally underappreciated. The rapidly expanding understanding of Alzheimer's disease (AD) pathogenesis now makes it possible to quantitate some of the likely long-term health risks associated with military service. Military risk factors for AD include both factors elevated in military personnel such as tobacco use, traumatic brain injury (TBI), depression, and post-traumatic stress disorder (PTSD) and other nonspecific risk factors for AD including, vascular risk factors such as obesity and obesity-related diseases (e.g., metabolic syndrome), education and physical fitness. The degree of combat exposure, Vietnam era Agent Orange exposure and Gulf War Illness may also influence risk for AD. Using available data on the association of AD and specific exposures and risk factors, the authors have conservatively estimated 423,000 new cases of AD in veterans by 2020, including 140,000 excess cases associated with specific military exposures. The cost associated with these excess cases is approximately $5.8 billion to $7.8 billion. Mitigation of the potential impact of military exposures on the cognitive function of veterans and management of modifiable risk factors through specifically designed programs will be instrumental in minimizing the impact of AD in veterans in the future decades. C1 [Veitch, Dallas P.; Weiner, Michael W.] Univ Calif San Francisco, Ctr Imaging Neurodegenerat Dis, Ctr Vet Med, San Francisco, CA 94143 USA. [Friedl, Karl E.] US Army Med Res & Mat Command, Telemed & Adv Technol Res Ctr, Ft Detrick, MD USA. [Weiner, Michael W.] Univ Calif San Francisco, Dept Radiol, San Francisco, CA 94143 USA. [Weiner, Michael W.] Univ Calif San Francisco, Dept Med, San Francisco, CA USA. [Weiner, Michael W.] Univ Calif San Francisco, Dept Psychiat, San Francisco, CA USA. [Weiner, Michael W.] Univ Calif San Francisco, Dept Neurol, San Francisco, CA USA. RP Weiner, MW (reprint author), Univ Calif San Francisco, Ctr Imaging Neurodegenerat Dis, Ctr Vet Med, San Francisco, CA 94143 USA. EM michael.weiner@ucsf.edu OI Friedl, Karl/0000-0002-3134-8427 NR 251 TC 17 Z9 18 U1 12 U2 34 PU BENTHAM SCIENCE PUBL LTD PI SHARJAH PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB EMIRATES SN 1567-2050 EI 1875-5828 J9 CURR ALZHEIMER RES JI Curr. Alzheimer Res. PD NOV PY 2013 VL 10 IS 9 BP 907 EP 930 PG 24 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA 241GO UT WOS:000326154600001 PM 23906002 ER PT J AU Mc Gann, P Milillo, M Kwak, YI Quintero, R Waterman, PE Lesho, E AF Mc Gann, Patrick Milillo, Michael Kwak, Yoon I. Quintero, Reyes Waterman, Paige E. Lesho, Emil TI Rapid and simultaneous detection of the chlorhexidine and mupirocin resistance genes qacA/B and mupA in clinical isolates of methicillin-resistant Staphylococcus aureus SO DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE LA English DT Article DE MRSA; Mupirocin; Chlorhexidine; MupA; QacA ID LOW-LEVEL MUPIROCIN; UNITED-STATES; DECOLONIZATION; MRSA AB We describe a real-time PCR-based assay capable of simultaneously detecting femA (Staphylococcus aureus-specific), mecA (methicillin resistance), qacA/B (chlorhexidine tolerance), and mupA (high-level mupirocin resistance) from bacterial cells in less than 90 minutes. The assay was validated with 1968 clinical MRSA submitted to a surveillance network. Published by Elsevier Inc. C1 [Mc Gann, Patrick; Milillo, Michael; Kwak, Yoon I.; Quintero, Reyes; Waterman, Paige E.; Lesho, Emil] Walter Reed Army Inst Res, Multidrug Resistant Organism Respository & Survei, Silver Spring, MD USA. RP Mc Gann, P (reprint author), Walter Reed Army Inst Res, Multidrug Resistant Organism Respository & Survei, Silver Spring, MD USA. EM patrick.tmcgann4@mail.mil FU US Army Medical Command; Department of Defense Global Emerging Infections Surveillance and Response System FX Major funding for this study was provided by the US Army Medical Command and the Department of Defense Global Emerging Infections Surveillance and Response System. NR 21 TC 8 Z9 8 U1 0 U2 7 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0732-8893 EI 1879-0070 J9 DIAGN MICR INFEC DIS JI Diagn. Microbiol. Infect. Dis. PD NOV PY 2013 VL 77 IS 3 BP 270 EP 272 DI 10.1016/j.diagmicrobio.2013.06.006 PG 3 WC Infectious Diseases; Microbiology SC Infectious Diseases; Microbiology GA 239EK UT WOS:000326005200020 PM 24034900 ER PT J AU Cheng, YW Zhang, HB Varanasi, CV Liu, J AF Cheng, Yingwen Zhang, Hongbo Varanasi, Chakrapani V. Liu, Jie TI Improving the performance of cobalt-nickel hydroxidebased self-supporting electrodes for supercapacitors using accumulative approaches SO ENERGY & ENVIRONMENTAL SCIENCE LA English DT Article ID LAYERED DOUBLE HYDROXIDES; ASYMMETRIC SUPERCAPACITORS; ELECTROCHEMICAL-BEHAVIOR; ACTIVATED CARBON; GRAPHENE; COMPOSITE; CAPACITANCE; DEPOSITION; NI(OH)(2); ENERGY AB In this paper we describe an accumulative approach to move beyond simple incorporation of conductive carbon nanostructures, such as graphene and carbon nanotubes, to improve the performance of metal oxide/hydroxide based electrodes in energy storage applications. In this approach we first synthesize Co-Ni double hydroxides/graphene binary composites through a co-precipitation process. We then assemble these composites into films (similar to 6 mg cm(-2)) by integrating with carbon nanotubes that can be used directly as electrodes. Experimental results indicate that the synergistic contributions from nanotubes, graphene and cobalt substitution enabled electrodes with substantially improved energy storage performance metrics. With 50% Co and 50% Ni (i.e. Co0.5Ni0.5(OH)(2)), the composite exhibited a remarkable maximum specific capacitance of 2360 F g(-1) (360 mA h g(-1)) at 0.5 A g(-1) and still maintained a specific capacitance as high as 2030 F g(-1) at 20 A g(-1) (similar to 86% retention). More importantly, the double hydroxides exhibited tunable redox behavior that can be controlled by the ratio between cobalt and nickel. These results demonstrate the importance of the rational design of functional composites and the large-scale assembly strategies for fabricating electrodes with improved performance and tunability for energy storage applications. C1 [Cheng, Yingwen; Zhang, Hongbo; Varanasi, Chakrapani V.; Liu, Jie] Duke Univ, Dept Chem, Durham, NC 27708 USA. [Cheng, Yingwen; Liu, Jie] Duke Univ, CEINT, Durham, NC 27708 USA. [Varanasi, Chakrapani V.] Army Res Off, Durham, NC 27703 USA. RP Cheng, YW (reprint author), Duke Univ, Dept Chem, Durham, NC 27708 USA. EM j.liu@duke.edu RI Cheng, Yingwen/B-2202-2012; Liu, Jie/B-4440-2010 OI Cheng, Yingwen/0000-0002-0778-5504; Liu, Jie/0000-0003-0451-6111 FU Army Research Office (ARO) [W911NF-04-D-0001]; National Science Foundation (NSF); Environmental Protection Agency (EPA) under NSF [EF-0830093]; Center for the Environmental Implications of Nano-Technology (CEINT); Duke SMIF FX This work is in part supported by a research grant from Army Research Office (ARO) under contract W911NF-04-D-0001 and the National Science Foundation (NSF) and the Environmental Protection Agency (EPA) under NSF Cooperative Agreement EF-0830093, Center for the Environmental Implications of Nano-Technology (CEINT). Any opinions, findings, conclusions or recommendations expressed in this material are those of the author(s) and do not necessarily reflect the views of the ARO, NSF or the EPA. This work has not been subjected to the EPA review and no official endorsement should be inferred. The authors also acknowledge the support from Duke SMIF (Shared Materials Instrumentation Facilities). NR 41 TC 69 Z9 69 U1 12 U2 123 PU ROYAL SOC CHEMISTRY PI CAMBRIDGE PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND SN 1754-5692 EI 1754-5706 J9 ENERG ENVIRON SCI JI Energy Environ. Sci. PD NOV PY 2013 VL 6 IS 11 BP 3314 EP 3321 DI 10.1039/c3ee41143e PG 8 WC Chemistry, Multidisciplinary; Energy & Fuels; Engineering, Chemical; Environmental Sciences SC Chemistry; Energy & Fuels; Engineering; Environmental Sciences & Ecology GA 238KW UT WOS:000325946400022 ER PT J AU Farrell, S Rao, MV Brill, G Chen, Y Wijewarnasuriya, P Dhar, N Benson, JD Harris, K AF Farrell, S. Rao, Mulpuri V. Brill, G. Chen, Y. Wijewarnasuriya, P. Dhar, N. Benson, J. D. Harris, K. TI Comparison of the Schaake and Benson Etches to Delineate Dislocations in HgCdTe Layers SO JOURNAL OF ELECTRONIC MATERIALS LA English DT Article DE HgCdTe; EPD; MBE; thermal cycle annealing; dislocations; Schaake etch; Benson etch; SEM ID MOLECULAR-BEAM EPITAXY; (112)B HGCDTE/CDTE/SI; REDUCTION; GAAS; SI; PHOTODIODES; PITS; CDTE AB The morphology and classification of etch pits in molecular beam epitaxy-grown (211) HgCdTe/CdTe/Si layers were investigated using the Schaake and Benson etch pit density (EPD) etches. The two EPD etches were compared and shown to have a 1:1 correlation in the etch pits that were produced. Close examination of the shape of the etch pits via scanning electron microscopy shows that several distinguishable classifications of etch pits are revealed using both etches. Samples subjected to thermal cycle annealing (TCA) treatment show a nonuniform reduction in etch pit populations according to the classification defined in this study. In particular, a class of etch pits called "fish shaped" are completely absent after TCA and can account for up to one-third of the total reduction in EPD. C1 [Farrell, S.; Rao, Mulpuri V.] George Mason Univ, Dept Elect & Comp Engn, Fairfax, VA 22030 USA. [Brill, G.; Chen, Y.; Wijewarnasuriya, P.; Dhar, N.] US Army, Res Lab, Sensors & Elect Devices Directorate, Adelphi, MD 20783 USA. [Benson, J. D.] US Army, RDECOM CERDEC Night Vis & Elect Sensors Directora, Ft Belvoir, VA USA. [Harris, K.] Penn State Electroopt Ctr, Freeport, PA 16229 USA. RP Farrell, S (reprint author), George Mason Univ, Dept Elect & Comp Engn, Fairfax, VA 22030 USA. EM farrell_stu@yahoo.com FU U.S. Army Research Office (ARO) [W911NF-07-2-0055]; Penn State Electro-Optics Center FX The work at George Mason University (GMU) is supported by the U.S. Army Research Office (ARO) under Grant No. W911NF-07-2-0055 and also by the Penn State Electro-Optics Center. NR 23 TC 4 Z9 4 U1 0 U2 6 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0361-5235 EI 1543-186X J9 J ELECTRON MATER JI J. Electron. Mater. PD NOV PY 2013 VL 42 IS 11 BP 3097 EP 3102 DI 10.1007/s11664-013-2657-1 PG 6 WC Engineering, Electrical & Electronic; Materials Science, Multidisciplinary; Physics, Applied SC Engineering; Materials Science; Physics GA 239SW UT WOS:000326046800013 ER PT J AU Reddy, M Lofgreen, DD Jones, KA Peterson, JM Radford, WA Benson, JD Johnson, SM AF Reddy, M. Lofgreen, D. D. Jones, K. A. Peterson, J. M. Radford, W. A. Benson, J. D. Johnson, S. M. TI Cross-Sectional Study of Macrodefects in MBE Dual-Band HgCdTe on CdZnTe SO JOURNAL OF ELECTRONIC MATERIALS LA English DT Article DE MBE; HgCdTe; dual band; macrodefects; STEM; FIB ID MOLECULAR-BEAM EPITAXY; DEFECTS; GROWTH; PERFORMANCE AB HgCdTe dual-band mid-wave infrared/long-wave infrared focal-plane arrays on CdZnTe are a key component in advanced electrooptic sensor applications. Molecular beam epitaxy (MBE) has been used successfully for growth of dual-band layers on larger CdZnTe substrates. However, the macrodefect density, which is known to reduce the pixel operability and its run-to-run variation, is larger when compared with layers grown on Si substrate. This paper reports the macrodefect density versus size signature of a well-optimized MBE dual-band growth and a cross-sectional study of a macrodefect that represents the most prevalent class using focused ion beam, scanning transmission electron microscopy, and energy-dispersive x-ray spectroscopy. The results show that the macrodefect originates from a void, which in turn is associated with a pit on the CdZnTe substrate. C1 [Reddy, M.; Lofgreen, D. D.; Jones, K. A.; Peterson, J. M.; Johnson, S. M.] Raytheon Vis Syst, Goleta, CA 93117 USA. [Radford, W. A.; Benson, J. D.] US Army RDECOM, CERDEC Night Vis & Elect Sensors, Ft Belvoir, VA USA. RP Reddy, M (reprint author), Raytheon Vis Syst, 75 Coromar Dr,B-2-8, Goleta, CA 93117 USA. EM Madhusudhana_reddy@raytheon.com NR 13 TC 4 Z9 4 U1 2 U2 14 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0361-5235 EI 1543-186X J9 J ELECTRON MATER JI J. Electron. Mater. PD NOV PY 2013 VL 42 IS 11 BP 3114 EP 3118 DI 10.1007/s11664-013-2660-6 PG 5 WC Engineering, Electrical & Electronic; Materials Science, Multidisciplinary; Physics, Applied SC Engineering; Materials Science; Physics GA 239SW UT WOS:000326046800016 ER PT J AU Kim, JJ Jacobs, RN Almeida, LA Jaime-Vasquez, M Nozaki, C Smith, DJ AF Kim, Jae Jin Jacobs, R. N. Almeida, L. A. Jaime-Vasquez, M. Nozaki, C. Smith, David J. TI TEM Characterization of HgCdTe/CdTe Grown on GaAs(211)B Substrates SO JOURNAL OF ELECTRONIC MATERIALS LA English DT Article DE HgCdTe; CdTe/GaAs(211)B; MBE; TEM; EDXS ID MOLECULAR-BEAM EPITAXY; ELECTRON-MICROSCOPY; CDTE HETEROEPITAXY; SI; EPILAYERS; QUALITY; SURFACE AB A microstructural study of HgCdTe/CdTe/GaAs(211)B and CdTe/GaAs(211)B heterostructures grown using molecular beam epitaxy (MBE) was carried out using transmission electron microscopy and small-probe microanalysis. High-quality MBE-grown CdTe on GaAs(211)B substrates was demonstrated to be a viable composite substrate platform for HgCdTe growth. In addition, analysis of interfacial misfit dislocations and residual strain showed that the CdTe/GaAs interface was fully relaxed except in localized regions where GaAs surface polishing had caused small pits. In the case of HgCdTe/CdTe/GaAs(211)B, the use of thin HgTe buffer layers between HgCdTe and CdTe for improving the HgCdTe crystal quality was also investigated. C1 [Kim, Jae Jin] Arizona State Univ, Sch Engn Matter Transport & Energy, Tempe, AZ 85287 USA. [Jacobs, R. N.; Almeida, L. A.; Jaime-Vasquez, M.; Nozaki, C.] US Army, RDECOM CERDEC Night Vis & Elect Sensors Directora, Ft Belvoir, VA USA. [Smith, David J.] Arizona State Univ, Dept Phys, Tempe, AZ 85287 USA. RP Kim, JJ (reprint author), Arizona State Univ, Sch Engn Matter Transport & Energy, Tempe, AZ 85287 USA. EM jaejin.kim@asu.edu; david.smith@asu.edu FU U.S. Army Research Laboratory; U.S. Army Research Office [54657] FX The work at Arizona State University has been supported by the U.S. Army Research Laboratory and the U.S. Army Research Office under Contract #54657 (Monitor: Dr. W. W. Clark). We also acknowledge the use of facilities in the John M. Cowley Center for High Resolution Electron Microscopy. NR 19 TC 2 Z9 2 U1 2 U2 20 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0361-5235 EI 1543-186X J9 J ELECTRON MATER JI J. Electron. Mater. PD NOV PY 2013 VL 42 IS 11 BP 3142 EP 3147 DI 10.1007/s11664-013-2688-7 PG 6 WC Engineering, Electrical & Electronic; Materials Science, Multidisciplinary; Physics, Applied SC Engineering; Materials Science; Physics GA 239SW UT WOS:000326046800022 ER PT J AU Jacobs, RN Stoltz, AJ Benson, JD Smith, P Lennon, CM Almeida, LA Farrell, S Wijewarnasuriya, PS Brill, G Chen, Y Salmon, M Zu, J AF Jacobs, R. N. Stoltz, A. J. Benson, J. D. Smith, P. Lennon, C. M. Almeida, L. A. Farrell, S. Wijewarnasuriya, P. S. Brill, G. Chen, Y. Salmon, M. Zu, J. TI Analysis of Mesa Dislocation Gettering in HgCdTe/CdTe/Si(211) by Scanning Transmission Electron Microscopy SO JOURNAL OF ELECTRONIC MATERIALS LA English DT Article DE HgCdTe thin films; dislocations; etch pit density; STEM; lattice-mismatched substrates; FIB ID (112)B HGCDTE/CDTE/SI; CDTE HETEROEPITAXY; HGCDTE; SI; REDUCTION; DENSITY AB Due to its strong infrared absorption and variable band-gap, HgCdTe is the ideal detector material for high-performance infrared focal-plane arrays (IRFPAs). Next-generation IRFPAs will utilize dual-color high-definition formats on large-area substrates such as Si or GaAs. However, heteroepitaxial growth on these substrates is plagued by high densities of lattice-mismatch-induced threading dislocations (TDs) that ultimately reduce IRFPA operability. Previously we demonstrated a postgrowth technique with the potential to eliminate or move TDs such that they have less impact on detector operability. In this technique, highly reticulated mesa structures are produced in as-grown HgCdTe epilayers, and then subjected to thermal cycle annealing. To fully exploit this technique, better understanding of the inherent mechanism is required. In this work, we employ scanning transmission electron microscopy (STEM) analysis of HgCdTe/CdTe/Si(211) samples prepared by focused ion beam milling. A key factor is the use of defect-decorated samples, which allows for a correlation of etch pits observed on the surface with underlying dislocation segments viewed in cross-section STEM images. We perform an analysis of these dislocations in terms of the general distribution, density, and mobility at various locations within the mesa structures. Based on our observations, we suggest factors that contribute to the underlying mechanism for dislocation gettering. C1 [Jacobs, R. N.; Stoltz, A. J.; Benson, J. D.; Smith, P.; Lennon, C. M.; Almeida, L. A.] US Army RDECOM, CERDEC Night Vis & Elect Sensors Directorate, Ft Belvoir, VA 22060 USA. [Farrell, S.; Wijewarnasuriya, P. S.; Brill, G.; Chen, Y.] US Army, Res Lab, Adelphi, MD 20783 USA. [Salmon, M.; Zu, J.] Evans Analyt Grp Inc, Raleigh, NC 27606 USA. RP Jacobs, RN (reprint author), US Army RDECOM, CERDEC Night Vis & Elect Sensors Directorate, Ft Belvoir, VA 22060 USA. EM rjacobs@nvl.army.mil NR 19 TC 1 Z9 1 U1 2 U2 11 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0361-5235 EI 1543-186X J9 J ELECTRON MATER JI J. Electron. Mater. PD NOV PY 2013 VL 42 IS 11 BP 3148 EP 3155 DI 10.1007/s11664-013-2691-z PG 8 WC Engineering, Electrical & Electronic; Materials Science, Multidisciplinary; Physics, Applied SC Engineering; Materials Science; Physics GA 239SW UT WOS:000326046800023 ER PT J AU Connelly, BC Metcalfe, GD Shen, HE Wraback, M Canedy, CL Vurgaftman, I Melinger, JS Affouda, CA Jackson, EM Nolde, JA Meyer, JR Aifer, EH AF Connelly, Blair C. Metcalfe, Grace D. Shen, Hongen Wraback, Michael Canedy, Chadwick L. Vurgaftman, Igor Melinger, Joseph S. Affouda, Chaffra A. Jackson, Eric M. Nolde, Jill A. Meyer, Jerry R. Aifer, Edward H. TI Investigation of Trap States in Mid-Wavelength Infrared Type II Superlattices Using Time-Resolved Photoluminescence SO JOURNAL OF ELECTRONIC MATERIALS LA English DT Article DE Type II superlattice; minority-carrier lifetime; time-resolved photoluminescence; Shockley-Read-Hall; trap saturation; infrared AB Time-resolved photoluminescence (TRPL) spectroscopy is used to study the minority-carrier lifetime in mid-wavelength infrared, n-type, InAs/Ga1-x In (x) Sb type II superlattices (T2SLs) and investigate the recombination mechanisms and trap states that currently limit their performance. Observation of multiple exponential decays in the intensity-dependent TRPL data indicates trap saturation due to the filling then emptying of trap states and different Shockley-Read-Hall (SRH) lifetimes for minority and majority carriers, with tau (maj) (tau (n0)) a parts per thousand << tau (min) (tau (p0)). Simulation of the photoluminescence transient captures the qualitative behavior of the TRPL data as a function of temperature and excess carrier density. A trap state native to Ga1-x In (x) Sb is identified from the low-injection temperature-dependent TRPL data and found to be located below the intrinsic Fermi level of the superlattice, approximately 60 +/- A 15 meV above the valence-band maximum. Low-temperature TRPL data show a variation of the minority-carrier SRH lifetime, tau (p0), over a set of InAs/Ga1-x In (x) Sb T2SLs, where tau (p0) increases as x is varied from 0.04 to 0.065 and the relative layer thickness of Ga1-x In (x) Sb is increased by 31%. C1 [Connelly, Blair C.; Metcalfe, Grace D.; Shen, Hongen; Wraback, Michael] US Army Res Lab, RDRL SEE M, Adelphi, MD 20783 USA. [Canedy, Chadwick L.; Vurgaftman, Igor; Melinger, Joseph S.; Affouda, Chaffra A.; Jackson, Eric M.; Nolde, Jill A.; Meyer, Jerry R.; Aifer, Edward H.] US Naval Res Lab, Washington, DC 20375 USA. RP Connelly, BC (reprint author), US Army Res Lab, RDRL SEE M, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM blair.connelly.ctr@mail.mil FU U.S. Army Research Laboratory Postdoctoral Fellowship Program FX B.C.C. would like to acknowledge research supported in part by an appointment to the U.S. Army Research Laboratory Postdoctoral Fellowship Program administered by the Oak Ridge Associated Universities through a cooperative agreement. NR 18 TC 12 Z9 12 U1 2 U2 22 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0361-5235 EI 1543-186X J9 J ELECTRON MATER JI J. Electron. Mater. PD NOV PY 2013 VL 42 IS 11 BP 3203 EP 3210 DI 10.1007/s11664-013-2759-9 PG 8 WC Engineering, Electrical & Electronic; Materials Science, Multidisciplinary; Physics, Applied SC Engineering; Materials Science; Physics GA 239SW UT WOS:000326046800031 ER PT J AU Benson, JD Bubulac, LO Lennon, CM Jacobs, RN Smith, PJ Markunas, JK Jaime-Vasquez, M Almeida, LA Stoltz, A Arias, JA Brill, G Chen, Y Wijewarnasuriya, PS Vilela, MF Peterson, J Johnson, SM Lofgreen, DD Rhiger, D Patten, EA Bangs, J AF Benson, J. D. Bubulac, L. O. Lennon, C. M. Jacobs, R. N. Smith, P. J. Markunas, J. K. Jaime-Vasquez, M. Almeida, L. A. Stoltz, A. Arias, J. A. Brill, G. Chen, Y. Wijewarnasuriya, P. S. Vilela, M. F. Peterson, J. Johnson, S. M. Lofgreen, D. D. Rhiger, D. Patten, E. A. Bangs, J. TI Impurity Gettering in (112)B HgCdTe/CdTe/Alternate Substrates SO JOURNAL OF ELECTRONIC MATERIALS LA English DT Article DE HgCdTe/CdTe/alternate substrate; molecular beam epitaxy; dislocations; in situ Te-stabilized thermal cyclic annealing; etch pit density; SIMS ID MOLECULAR-BEAM EPITAXY; RECENT PROGRESS; MBE GROWTH; HGCDTE; COPPER; THERMOMIGRATION; (HG,CD)TE; REDUCTION; CRYSTALS; QUALITY AB The crystalline structure and impurity profiles of HgCdTe/CdTe/alternate substrate (AS; Si and GaAs are possibilities) and CdTe/AS were analyzed by secondary-ion mass spectrometry, atomic force microscopy, etch pit density analysis, and scanning transmission electron microscopy. Impurities (Li, Na, and K) were shown to getter in as-grown CdTe/Si epilayers at in situ Te-stabilized thermal anneal (similar to 500A degrees C) interfaces. In HgCdTe/CdTe/Si epilayers, indium accumulation was observed at Te-stabilized thermal anneal interfaces. Impurity accumulation was measured at HgCdTe/CdTe and CdTe/ZnTe interfaces. Processing anneals were found to nearly eliminate the gettering effect at the in situ Te-stabilized thermal anneal interfaces. Impurities were found to redistribute to the front HgCdTe/CdTe/Si surface and p-n junction interfaces during annealing steps. We also investigated altering the in situ Te-stabilized thermal anneal process to enhance the gettering effect. C1 [Benson, J. D.; Bubulac, L. O.; Lennon, C. M.; Jacobs, R. N.; Smith, P. J.; Markunas, J. K.; Jaime-Vasquez, M.; Almeida, L. A.; Stoltz, A.; Arias, J. A.] US Army RDECOM, CERDEC Night Vis & Elect Sensors Directorate, Ft Belvoir, VA USA. [Brill, G.; Chen, Y.; Wijewarnasuriya, P. S.] US Army Res Lab, Adelphi, MD USA. [Vilela, M. F.; Peterson, J.; Johnson, S. M.; Lofgreen, D. D.; Rhiger, D.; Patten, E. A.; Bangs, J.] Raytheon Vis Syst, Goleta, CA USA. RP Benson, JD (reprint author), US Army RDECOM, CERDEC Night Vis & Elect Sensors Directorate, Ft Belvoir, VA USA. EM david.j.benson@us.army.mil NR 24 TC 1 Z9 1 U1 0 U2 12 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0361-5235 EI 1543-186X J9 J ELECTRON MATER JI J. Electron. Mater. PD NOV PY 2013 VL 42 IS 11 BP 3217 EP 3223 DI 10.1007/s11664-013-2780-z PG 7 WC Engineering, Electrical & Electronic; Materials Science, Multidisciplinary; Physics, Applied SC Engineering; Materials Science; Physics GA 239SW UT WOS:000326046800033 ER PT J AU Brown, AE Jaime-Vasquez, M Almeida, LA Arias, J Lennon, CM Jacobs, RN Pellegrino, J Sivananthan, S AF Brown, A. E. Jaime-Vasquez, M. Almeida, L. A. Arias, J. Lennon, C. M. Jacobs, R. N. Pellegrino, J. Sivananthan, S. TI Variable-Field Hall Measurement and Transport in LW Single-Layer n-Type MBE Hg1-x Cd (x) Te SO JOURNAL OF ELECTRONIC MATERIALS LA English DT Article DE HgCdTe; electrical characterization; molecular beam epitaxy; quantitative mobility spectrum analysis (QMSA); Hall-effect measurement; multicarrier conduction ID MOBILITY-SPECTRUM ANALYSIS; MOLECULAR-BEAM EPITAXY; LPE-GROWN HG1-XCDXTE; MAGNETOTRANSPORT CHARACTERIZATION; CARRIER CONCENTRATION; HGCDTE; CONDUCTION; SCATTERING AB Molecular beam epitaxy n-type long-wavelength infrared (LWIR) Hg1-x Cd (x) Te (MCT) has been investigated using variable-field Hall measurement in the temperature range from 50 K to 293 K. A quantitative mobility spectrum analysis technique has been used to determine the role of multicarrier transport properties with respect to epilayer growth on lattice-matched cadmium zinc telluride, as well as lattice-mismatched silicon (Si) and gallium arsenide (GaAs) buffered substrates. Overall, after postgrowth annealing, all layers were found to possess three distinct electron species, which were postulated to originate from the bulk, transitional (or higher-x-value) regions, and an interfacial/surface layer carrier. Further, the mobility and concentration with respect to temperature were analyzed for all carriers, showing the expected mobility temperature dependence and intrinsic behavior of the bulk electron. Electrons from transitional regions were seen to match expected values based on the carrier concentration of the resolved peak. At high temperature, the lowest-mobility carrier was consistent with the properties of a surface carrier, while below 125 K it was postulated that interfacial-region electrons may influence peak values. After corrections for x-value and doping density at 77 K, bulk electron mobility in excess of 10(5) cm(2) V-1 s(-1) was observed in all epilayers, in line with expected values for lightly doped n-type LWIR material. Results indicate that fundamental conduction properties of electrons in MCT layers are unchanged by choice of substrate. C1 [Brown, A. E.; Jaime-Vasquez, M.; Almeida, L. A.; Arias, J.; Lennon, C. M.; Jacobs, R. N.; Pellegrino, J.] US Army RDECOM, CERDEC Night Vis & Elect Sensors Directorate, Ft Belvoir, VA USA. [Arias, J.] RAND Corp, Santa Monica, CA USA. [Lennon, C. M.] Corbin Co, Alexandria, VA USA. [Brown, A. E.; Sivananthan, S.] Univ Illinois, Microphys Lab, Chicago, IL USA. RP Brown, AE (reprint author), US Army RDECOM, CERDEC Night Vis & Elect Sensors Directorate, Ft Belvoir, VA USA. EM abrown52@uic.edu NR 23 TC 2 Z9 2 U1 1 U2 15 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0361-5235 EI 1543-186X J9 J ELECTRON MATER JI J. Electron. Mater. PD NOV PY 2013 VL 42 IS 11 BP 3224 EP 3230 DI 10.1007/s11664-013-2781-y PG 7 WC Engineering, Electrical & Electronic; Materials Science, Multidisciplinary; Physics, Applied SC Engineering; Materials Science; Physics GA 239SW UT WOS:000326046800034 ER PT J AU Lennon, CM Almeida, LA Jacobs, RN Benson, JD Smith, PJ Markunas, JK Arias, J Pellegrino, J AF Lennon, C. M. Almeida, L. A. Jacobs, R. N. Benson, J. D. Smith, P. J. Markunas, J. K. Arias, J. Pellegrino, J. TI The Surface Kinetics of MBE-Grown CdTe (211)B During In Situ Cyclic Annealing SO JOURNAL OF ELECTRONIC MATERIALS LA English DT Article DE CdTe; HgCdTe; GaAs; molecular beam epitaxy; spectroscopic ellipsometry ID MOLECULAR-BEAM EPITAXY; HGCDTE; QUALITY; HETEROEPITAXY; SUBLIMATION; HG1-XCDXTE; REDUCTION; FILMS AB The surface kinetics of CdTe (211)B grown by molecular beam epitaxy (MBE) is investigated using spectroscopic ellipsometry (SE) during in situ cyclic annealing. A method of measuring sublimation rates from high-index surfaces without use of reflection high-energy electron diffraction is presented. The effect of Te-2 overpressure on the activation energy of sublimation for the CdTe (211)B surface is reported. The sensitivity of SE to surface temperature and film thickness was leveraged to monitor sublimation rates of CdTe stabilized by a Te-2 overpressure. The sublimation activation energy was found to increase from 0.45 eV to 2.94 eV under the Te-2 beam pressure regime investigated. C1 [Lennon, C. M.] Corbin Co, Alexandria, VA 22314 USA. [Almeida, L. A.; Jacobs, R. N.; Benson, J. D.; Smith, P. J.; Markunas, J. K.; Arias, J.; Pellegrino, J.] US Army RDECOM, CERDEC, Night Vis & Elect Sensors Directorate, Ft Belvoir, VA 22060 USA. [Arias, J.] RAND Corp, Santa Monica, CA 90401 USA. RP Lennon, CM (reprint author), Corbin Co, Alexandria, VA 22314 USA. EM info@us.army.mil NR 17 TC 1 Z9 1 U1 0 U2 3 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0361-5235 EI 1543-186X J9 J ELECTRON MATER JI J. Electron. Mater. PD NOV PY 2013 VL 42 IS 11 BP 3344 EP 3348 DI 10.1007/s11664-013-2767-9 PG 5 WC Engineering, Electrical & Electronic; Materials Science, Multidisciplinary; Physics, Applied SC Engineering; Materials Science; Physics GA 239SW UT WOS:000326046800050 ER PT J AU Wan, CF Orent, T Myers, T Bhat, I Stoltz, A Pellegrino, J AF Wan, Chang-Feng Orent, Thomas Myers, Thomas Bhat, Ishwara Stoltz, Andy Pellegrino, Joe TI A Novel Metal-Rich Anneal for In Vacuo Passivation of High-Aspect-Ratio Mercury Cadmium Telluride Surfaces SO JOURNAL OF ELECTRONIC MATERIALS LA English DT Article DE Passivation; HgCdTe; infrared FPA; photodiode; Cd-rich anneal; high aspect ratio ID INTERDIFFUSION; CDTE AB A new method for Cd-rich annealing of mercury cadmium telluride (MCT) was developed based on the observation that the deposition of Cd onto MCT by vacuum evaporation became self-limiting whenever the substrate temperature was above 70A degrees C regardless of the Cd evaporation rate. Preliminary results indicated that this new method may be suitable for passivation of high-aspect-ratio MCT surfaces, for passivation at low temperatures, for in vacuo operation, and/or for vacancy annihilation in MCT. Furthermore, the process can be carried out in the conventional open-tube reactors used for molecular beam epitaxy, metalorganic chemical vapor deposition, and physical vapor deposition. C1 [Wan, Chang-Feng; Orent, Thomas] VISM Corp, Dallas, TX USA. [Myers, Thomas] Texas State Univ San Marcos, San Marcos, TX USA. [Bhat, Ishwara] Rensselaer Polytech Inst, Troy, NY USA. [Stoltz, Andy; Pellegrino, Joe] US Army, RDECOM, CERDEC, NVESD, Ft Belvoir, VA USA. RP Wan, CF (reprint author), VISM Corp, Dallas, TX USA. EM cfwan@swbell.net RI Myers, Thomas/C-3769-2013 FU US DoD SBIR [W909MY-11-C-0027] FX The authors wish to acknowledge Dr. Leigh Ann Files for GA-WDS-XRF analysis, Carlos Aramayo for technical assistance, and Dr. Herb Schaake for helpful discussion. This work is supported in part by US DoD SBIR Contract No. W909MY-11-C-0027. NR 14 TC 1 Z9 1 U1 1 U2 9 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0361-5235 EI 1543-186X J9 J ELECTRON MATER JI J. Electron. Mater. PD NOV PY 2013 VL 42 IS 11 BP 3359 EP 3366 DI 10.1007/s11664-013-2818-2 PG 8 WC Engineering, Electrical & Electronic; Materials Science, Multidisciplinary; Physics, Applied SC Engineering; Materials Science; Physics GA 239SW UT WOS:000326046800052 ER PT J AU Le, Y Kipfer, H Majidi, S Holz, S Dale, B Geppert, C Kroeker, R Lin, C AF Le, Yuan Kipfer, Hal Majidi, Shadie Holz, Stephanie Dale, Brian Geppert, Christian Kroeker, Randall Lin, Chen TI Application of Time-Resolved Angiography With Stochastic Trajectories (TWIST)-Dixon in Dynamic Contrast-Enhanced (DCE) Breast MRI SO JOURNAL OF MAGNETIC RESONANCE IMAGING LA English DT Article DE dynamic contrast enhancement; breast MRI; fat suppression; Dixon; TWIST; view sharing ID FAT-SUPPRESSION; ACQUISITION; DIXON; SEQUENCE; EFFICIENCY; PITFALLS; SPACE; TWIST AB PurposeTo evaluate a magnetic resonance imaging (MRI) technique that integrates time-resolved angiography with stochastic trajectories (TWIST) view sharing and Dixon for a breast dynamic contrast-enhanced (DCE)-MRI application. Materials and MethodsSimulation study: K-space data at six timepoints (1 pre-, 5 postcontrast) were generated by performing Fourier transform on a digital phantom with 3-9 mm enhancing lesions and three types of enhancement curves (persistent, plateau, washout). Images were reconstructed with and without TWIST. Clinical study: Six TWIST-Dixon image sets (one pre-, five postcontrast) were acquired in 18 patients on a 3T scanner, followed by one conventional image set. The last TWIST-Dixon and the conventional images were scored for seven criteria: perceived signal-to-noise ratio (P.SNR), visualization of anatomy, fat suppression (FS) accuracy, FS uniformity, ghosting artifact, edge ringing artifact, and overall image quality (IQ). ResultsSimulation study: With proper TWIST parameters (pA 33%, pB 50%), the enhancement underestimation was 5% or less for tumor size 5 mm. Clinical study: TWIST-Dixon images have significantly better scores in all criteria except for ghosting artifacts, where the difference was not significant. ConclusionWith proper parameters, TWIST-Dixon provides higher perceived SNR, more accurate fat suppression, and better overall image quality for breast DCE-MRI without sacrificing accuracy in the enhancement estimation. J. Magn. Reson. Imaging 2013;38:1033-1042. (c) 2013 Wiley Periodicals, Inc. C1 [Le, Yuan; Kipfer, Hal; Majidi, Shadie; Holz, Stephanie; Lin, Chen] Indiana Univ Sch Med, Dept Radiol & Imaging Sci, Indianapolis, IN 46202 USA. [Dale, Brian] USA, Siemens Med Solut, MR R&D, Morrisville, NC USA. [Geppert, Christian] Siemens Healthcare, MR Oncol, Erlangen, Germany. [Kroeker, Randall] Siemens Healthcare, Erlangen, Germany. RP Lin, C (reprint author), Indiana Univ Sch Med, Dept Radiol & Imaging Sci, 950 West Walnut St R2 E124, Indianapolis, IN 46202 USA. EM clin1@iupui.edu RI Le, Yuan/A-8401-2012 FU Siemens Healthcare FX Contract grant sponsor: Siemens Healthcare. NR 25 TC 5 Z9 5 U1 0 U2 11 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1053-1807 EI 1522-2586 J9 J MAGN RESON IMAGING JI J. Magn. Reson. Imaging PD NOV PY 2013 VL 38 IS 5 BP 1033 EP 1042 DI 10.1002/jmri.24062 PG 10 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA 241DP UT WOS:000326146900006 PM 24038452 ER PT J AU Grubb, TG Pater, LL Gatto, AE Delaney, DK AF Grubb, Teryl G. Pater, Larry L. Gatto, Angela E. Delaney, David K. TI Response of Nesting Northern Goshawks to Logging Truck Noise in Northern Arizona SO JOURNAL OF WILDLIFE MANAGEMENT LA English DT Article DE Accipiter gentilis; aircraft; forest roads; human disturbance; logging truck; management; noise; northern goshawk; response behavior ID PREY AB We recorded 94 sound-response events at 3 adult-occupied northern goshawk (Accipiter gentilis) nests 78m, 143m, and 167m from the nearest United States Forest Service maintenance level 3, improved gravel road on the Kaibab Plateau in northern Arizona. During 4 test sessions on 7, 8, 10, and 11 June 2010, we recorded 60 experimentally controlled logging trucks; 30 non-experimental, civilian, fixed-winged aircraft; 3 non-experimental, passing cars; and 1 all-terrain vehicle (ATV). Logging truck sound, principally engine and exhaust, was concentrated in the 63Hz and 80Hz, 1/3-octave frequency bands. Aircraft sound was concentrated in the 100Hz and 125Hz, 1/3-octave frequency bands. Logging truck noise levels varied among nest sites and with distance from roads. At 167m from the closest road, the logging truck averaged approximately 8 decibels (dB, all decibel levels C-weighted, adjusted, 1s, equivalent sound level, CLEQ) quieter than aircraft. At 143m, the logging truck was approximately 3dB quieter than passing aircraft. Only at 78m was logging truck noise louder on average than aircraft, by approximately 6dB. Average aircraft noise levels for each day of testing ranged between 45.6dB and 67.9dB and when averaged across the entire study period, varied little among the 3 test sites, 60.1-65.6dB. On average, our test logging truck (61.9dB) was no louder than passing aircraft (62.3dB), which goshawks generally ignored. The logging truck resulted in 27% no response and 73% alert (head turning) response, passing aircraft resulted in 90% no response and only 10% alert response, and the cars and ATV combined resulted in 50% each for no response and alert response. Goshawk alert response rates were inversely proportional to nest distance from the nearest road, decreasing from 91% to 57% alert between 78m and 167m. No movements or flushes were associated with either our experimental testing or passive recording of other vehicular noise stimuli. All tested pairs of goshawks successfully fledged young. Because logging truck noise had no effect on northern goshawks nesting along level 3, improved gravel roads on the Kaibab Plateau, restriction of log hauling and other road-based travel activities on similar roads within post-fledging family areas (PFAs) appears unnecessary based on the type and extent of our testing. (c) 2013 The Wildlife Society. C1 [Grubb, Teryl G.] US Forest Serv, Rocky Mt Res Stn, Flagstaff, AZ 86001 USA. [Gatto, Angela E.] US Forest Serv, Kaibab Natl Forest, Fredonia, AZ 86022 USA. [Delaney, David K.] US Army Engn Res & Dev Ctr, Construct Engn Res Lab, Champaign, IL 61822 USA. RP Grubb, TG (reprint author), US Forest Serv, Rocky Mt Res Stn, 2500 S Pine Knoll Dr, Flagstaff, AZ 86001 USA. EM tgrubb@fs.fed.us FU Kaibab National Forest FX The authors would like to thank NKRD field technicians R. Dastrup, C. Hagemann, and K. Miles for their dedication and long hours in the field recording logging truck and other noise levels, while diligently observing northern goshawk response behaviors. D. Saunders and P. Callaway, NKRD foresters, provided valuable advice and insight into log hauling operations. The cooperation of L. Reidhead, logging truck owner operator, is also greatly appreciated. R. Reynolds, Rocky Mountain Research Station scientist, and his field crews provided much helpful information on northern goshawk nesting activities, nest locations, and adult behaviors. C. King, formerly with NKRD and now with Arizona Department of Game and Fish, is gratefully acknowledged for her pioneering research into logging truck noise levels and effects on northern goshawk behavior in 2001-2002, a project that precipitated the current research effort. We thank R. Reynolds and J. Cooper for reviewing an earlier draft manuscript, and S. Baggett for statistical advice. We also appreciate the helpful comments of 2 anonymous reviewers. Primary funding for field data collection and analyses was provided by the Kaibab National Forest. We thank S. Brown, Kaibab National Forest Contracting, for facilitating that financial support. The U.S. Forest Service, Rocky Mountain Research Station, and U.S. Army, Engineer Research and Development Center, Construction Engineering Research Laboratory provided technical and logistical support. Use of trade names does not imply endorsement by any of the participating agencies to the exclusion of other potentially suitable products or services. NR 26 TC 1 Z9 1 U1 0 U2 27 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0022-541X EI 1937-2817 J9 J WILDLIFE MANAGE JI J. Wildl. Manage. PD NOV PY 2013 VL 77 IS 8 BP 1618 EP 1625 DI 10.1002/jwmg.607 PG 8 WC Ecology; Zoology SC Environmental Sciences & Ecology; Zoology GA 239GR UT WOS:000326011100015 ER PT J AU Shukla, MK Leszczynski, J AF Shukla, Manoj K. Leszczynski, Jerzy TI Tautomerism in nucleic acid bases and base pairs: a brief overview SO WILEY INTERDISCIPLINARY REVIEWS-COMPUTATIONAL MOLECULAR SCIENCE LA English DT Review ID DENSITY-FUNCTIONAL THEORY; AB-INITIO CALCULATIONS; POST-HARTREE-FOCK; INTRAMOLECULAR PROTON-TRANSFER; ELECTRON CORRELATION CONTRIBUTIONS; EXPERIMENTAL MATRIX-ISOLATION; INFRARED-LASER SPECTROSCOPY; HYDROGEN-BONDED COMPLEXES; TRANSITION-MOMENT ANGLES; C-13 MAGNETIC-RESONANCE AB This article provides a brief overview of current status of studies on nucleic acid bases and base pairs tautomeric properties in the different environments. Applications of high-level theoretical calculations have been found to be extremely useful in interpreting and enlightening complex experimental results. Actually, theory and experiments are complementary to each other and therefore it is not surprising that application of theoretical calculations were necessary to assign relatively higher energy tautomers of guanine in the gas phase. Inability to observe the stable tautomers in the laser-desorbed guanine in the jet-cooled beam demands more experiments and rigorous analysis. The usefulness of theoretical methods in the assignment of tautomeric forms of other bases and base pairs has also been discussed. Furthermore, we would like to state that recent surge in the high-level computation of system such as nucleic acid bases and base pairs is only possible due to the advancement in state-of-the-art computer hardware and computational algorithms. Afterward, it is not unexpected to assume that future investigations would utilize high-level quantum chemistry calculation more rigorously in explaining complex experimental data as well as in revealing new phenomena not studied by experiments. (C) 2013 John Wiley & Sons, Ltd. C1 [Leszczynski, Jerzy] Jackson State Univ, Dept Chem & Biochem, Interdisciplinary Ctr Nanotox, Jackson, MS 39217 USA. [Shukla, Manoj K.] US Army ERDC, Vicksburg, MS 39180 USA. RP Leszczynski, J (reprint author), Jackson State Univ, Dept Chem & Biochem, Interdisciplinary Ctr Nanotox, Jackson, MS 39217 USA. EM jerzy@icnanotox.org FU NSF CREST [9805465]; National Science Foundation (NSF) through Georgia Tech University [CHE-0739189] FX This study was supported by the NSF CREST Grant No. 9805465 in part by the Origin of Life project funded by the National Science Foundation (NSF) through Georgia Tech University grant no. CHE-0739189. NR 114 TC 13 Z9 13 U1 3 U2 46 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1759-0876 EI 1759-0884 J9 WIRES COMPUT MOL SCI JI Wiley Interdiscip. Rev.-Comput. Mol. Sci. PD NOV PY 2013 VL 3 IS 6 BP 637 EP 649 DI 10.1002/wcms.1145 PG 13 WC Chemistry, Multidisciplinary; Mathematical & Computational Biology SC Chemistry; Mathematical & Computational Biology GA 239PU UT WOS:000326038700006 ER PT J AU Shah, R Reyes-Gordillo, K Arellanes-Robledo, J Lechuga, CG Hernandez-Nazara, Z Cotty, A Rojkind, M Lakshman, MR AF Shah, Ruchi Reyes-Gordillo, Karina Arellanes-Robledo, Jaime Lechuga, Carmen G. Hernandez-Nazara, Zamira Cotty, Adam Rojkind, Marcos Lakshman, M. Raj TI TGF-beta 1 Up-Regulates the Expression of PDGF-b Receptor mRNA and Induces a Delayed PI3K-, AKT-, and p70 S6K-Dependent Proliferative Response in Activated Hepatic Stellate Cells SO ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH LA English DT Article DE TGF-beta 1; PDGF- Receptor; Proliferation; Hepatic Stellate Cells; Liver Fibrosis ID GROWTH-FACTOR-BETA; NECROSIS-FACTOR-ALPHA; COLLAGEN GENE-TRANSCRIPTION; FAT-STORING CELLS; LIVER FIBROSIS; TRANSFORMING GROWTH-FACTOR-BETA-1; TGF-BETA; MESENCHYMAL TRANSITION; DEPENDENT MECHANISM; HYDROGEN-PEROXIDE AB Background Transforming growth factor beta 1 (TGF-1) is a pleiotropic cytokine that activates hepatic stellate cell (HSC) proliferation, but inhibits parenchymal cell proliferation. Therefore, we hypothesize that TGF-1 regulates HSC proliferation and elucidated its molecular action. MethodsIn order to elucidate the molecular mechanism whereby TGF-1 up-regulates platelet derived growth factor beta (PDGF-) receptor mRNA and induces a delayed proliferation of HSC, we used proliferation and apoptosis assays as well as RT-PCR, Western blot analysis, immunostaining, and flow cytometry in mouse and rat HSC. ResultsWe show that TGF-1 markedly induces the proliferation of mouse HSC in culture with concomitant 2.1-fold (p<0.001) stimulation in [H-3]-thymidine incorporation into cellular DNA. This induction is maximal between 24 and 36hours postcytokine exposure that is triggered by 7.6-fold (p<0.001) up-regulation of PDGF- receptor mRNA and associated increase in PDGF- receptor protein after 48hours. TGF-1-dependent HSC proliferation is mimicked by H2O2 that is inhibited by catalase, implying that TGF-1 action is mediated via reactive oxygen species. HSC proliferation is blunted by PDGF- receptor-neutralizing antibody as well as by specific inhibitors of PI3 kinase (PI3K), AKT, and p70(S6K), indicating that the action of TGF-1 involves the activation of PDGF- receptor via the PI3K/AKT/p70(S6K) signaling pathway. TGF-1 also induces a reorganization of actin and myosin filaments and cell morphology leading to the formation of palisades although their myosin and actin contents remained constant. These findings suggest that TGF-1-mediated oxidative stress causes the transdifferentiation of HSC and primes them for extracellular matrix (ECM) deposition and scar contraction. ConclusionsWe conclude that liver injury up-regulates TGF-1 that inhibits parenchymal cell proliferation, but stimulates HSC proliferation leading to the production of ECM and type I collagen resulting in fibrosis. C1 [Shah, Ruchi; Reyes-Gordillo, Karina; Arellanes-Robledo, Jaime; Lakshman, M. Raj] VA Med Ctr, Lipid Res Lab, Washington, DC 20422 USA. [Shah, Ruchi; Reyes-Gordillo, Karina; Arellanes-Robledo, Jaime; Hernandez-Nazara, Zamira; Rojkind, Marcos; Lakshman, M. Raj] George Washington Univ, Med Ctr, Dept Biochem & Mol Biol, Washington, DC 20037 USA. [Lechuga, Carmen G.; Hernandez-Nazara, Zamira; Cotty, Adam; Rojkind, Marcos] Albert Einstein Coll Med, Marion Bessin Liver Res Ctr, Bronx, NY 10467 USA. [Lechuga, Carmen G.] Ctr Nacl Invest Oncol, Dept Mol Oncol, Madrid, Spain. [Hernandez-Nazara, Zamira] Univ Guadalajara, Dept Fisiol, Guadalajara 44430, Jalisco, Mexico. [Rojkind, Marcos] Walter Reed Army Med Ctr, Dept Clin Invest, Expt Pathol Sect, Washington, DC 20307 USA. [Rojkind, Marcos] Walter Reed Army Med Ctr, Dept Clin Invest, Immunol Sect, Washington, DC 20307 USA. RP Lakshman, MR (reprint author), VA Med Ctr, Res Labs, 50 Irving St NW, Washington, DC 20422 USA. EM raj.lakshman@va.gov RI Shah, Ramille/E-3737-2010 FU Ministerio de Educacion y Cultura, Spain; [RO1 AA09231]; [RO1 AA10541] FX This work was supported in part by grants RO1 AA09231 and RO1 AA10541 (MRL). CGL acknowledges the support in part from a grant from the Ministerio de Educacion y Cultura, Spain. The authors are indebted to Dr. Anne Bresnick, Albert Einstein College of Medicine, for her generous gift of antimyosin antibodies and for helpful discussion of the findings. The authors also thank Yvonne Lukes, Gregory Desierto, Parwana Ashari, and Moran Choe for their advice and assistance. NR 41 TC 13 Z9 15 U1 2 U2 16 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0145-6008 EI 1530-0277 J9 ALCOHOL CLIN EXP RES JI Alcoholism (NY) PD NOV PY 2013 VL 37 IS 11 BP 1838 EP 1848 DI 10.1111/acer.12167 PG 11 WC Substance Abuse SC Substance Abuse GA 239QB UT WOS:000326039400005 PM 23895226 ER PT J AU Sherwin, J Sajda, P AF Sherwin, Jason Sajda, Paul TI Musical experts recruit action-related neural structures in harmonic anomaly detection: Evidence for embodied cognition in expertise SO BRAIN AND COGNITION LA English DT Article DE Electroencephalography (EEG); Expertise; Single-trial analysis; Pattern recognition; Perceptual decision-making ID ELECTROMAGNETIC TOMOGRAPHY LORETA; BIMANUAL COORDINATION; SPEECH-PERCEPTION; BRAIN; MUSICIANS; PIANISTS; ERP; COMPREHENSION; DYNAMICS; PERFORMANCE AB Humans are extremely good at detecting anomalies in sensory input. For example, while listening to a piece of Western-style music, an anomalous key change or an out-of-key pitch is readily apparent, even to the non-musician. In this paper we investigate differences between musical experts and non-experts during musical anomaly detection. Specifically, we analyzed the electroencephalograms (EEG) of five expert cello players and five non-musicians while they listened to excerpts of J.S. Bach's Prelude from Cello Suite No. 1. All subjects were familiar with the piece, though experts also had extensive experience playing the piece. Subjects were told that anomalous musical events (AMEs) could occur at random within the excerpts of the piece and were told to report the number of AMEs after each excerpt. Furthermore, subjects were instructed to remain still while listening to the excerpts and their lack of movement was verified via visual and EEG monitoring. Experts had significantly better behavioral performance (i.e. correctly reporting AME counts) than non-experts, though both groups had mean accuracies greater than 80%. These group differences were also reflected in the EEG correlates of key-change detection post-stimulus, with experts showing more significant, greater magnitude, longer periods of, and earlier peaks in condition-discriminating EEG activity than novices. Using the timing of the maximum discriminating neural correlates, we performed source reconstruction and compared significant differences between cellists and non-musicians. We found significant differences that included a slightly right lateralized motor and frontal source distribution. The right lateralized motor activation is consistent with the cortical representation of the left hand - i.e. the hand a cellist would use, while playing, to generate the anomalous key-changes. In general, these results suggest that sensory anomalies detected by experts may in fact be partially a result of an embodied cognition, with a model of the action for generating the anomaly playing a role in its detection. (c) 2013 Elsevier Inc. All rights reserved. C1 [Sherwin, Jason; Sajda, Paul] Columbia Univ, Dept Biomed Engn, New York, NY 10027 USA. [Sherwin, Jason] US Army Res Lab, Human Res & Engn Directorate, Aberdeen, MD 21001 USA. RP Sherwin, J (reprint author), Columbia Univ, Dept Biomed Engn, New York, NY 10027 USA. EM jason.sherwin@columbia.edu FU Army Research Office [W911NF-11-1-0219]; National Institutes of Health [R01-MH085092] FX This work was supported a Grant from the Army Research Office (W911NF-11-1-0219), National Institutes of Health grant R01-MH085092, and in part by an appointment to the U.S. Army Research Laboratory Postdoctoral Fellowship Program administered by the Oak Ridge Associated Universities through a contract with the U.S. Army Research Laboratory. NR 52 TC 7 Z9 7 U1 1 U2 25 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0278-2626 EI 1090-2147 J9 BRAIN COGNITION JI Brain Cogn. PD NOV PY 2013 VL 83 IS 2 BP 190 EP 202 DI 10.1016/j.bandc.2013.07.002 PG 13 WC Neurosciences; Psychology, Experimental SC Neurosciences & Neurology; Psychology GA 235SI UT WOS:000325740600005 PM 24056235 ER PT J AU Bhimani, S Alvarado, JL Annamalai, K Marsh, C AF Bhimani, Shreyas Alvarado, Jorge L. Annamalai, Kalyan Marsh, Charles TI Emission characteristics of methanol-in-canola oil emulsions in a combustion chamber SO FUEL LA English DT Article DE Canola oil; Methanol; Swirler; Emulsion; Twin-fluid atomizer ID NUMBER; FUELS AB This paper focuses on the emulsification and combustion characteristics of different methanol-in-canola oil blends subject to different conditions including swirl number and equivalence ratio. Exhaust emissions data such as nitrogen oxides (NOx), unburned hydrocarbons (UHC's), carbon monoxide (CO) and carbon dioxide (CO2) emission levels were measured and analyzed thoroughly. Stable methanol-in-canola oil emulsions were made by using a combination of Span 80 and Tween 80 surfactants. The three different fuels studied were; pure canola oil, 89-9 emulsion [9% methanol - in - 89% canola oil emulsion with 2% surfactant (w/w)] and 85-12.5 emulsion [12.5% methanol - in - 85% canola oil emulsion with 2.5% surfactant (w/w)]. All the experiments were conducted in a 30 kW combustion chamber equipped with a twin fluid atomizer and a radial vane swirler. The swirler vanes were positioned at 60 degrees and 51 degrees angles (with respect to vertical axis) in order to achieve swirl numbers (SNs) of 1.40 and 1.0, respectively. The fuels were tested at equivalence ratios (phi) of 0.83, 0.91, 1.0, 1.05 and 1.11. Ultimate analysis, higher heating value (HHV), kinematic viscosity and density were used to characterize the fuel properties. Experimental results showed that fuel type and swirl number had a major influence on emission levels. All the emulsions produced lower NOx, CO and unburned hydrocarbon emissions than pure canola oil at both swirl numbers and all equivalence ratios. The emulsions also produced higher CO2 emissions than pure canola oil. On comparing the performance of the emulsions, it was seen that the addition of methanol to the blend had a definite positive impact on the combustion characteristics. It was observed that higher percentage of methanol in the emulsions led to lesser NOx, UHC and CO emissions. The vorticity imparted to the secondary air by the swirler also affected emission levels considerably. Increased vorticity at higher swirl angle led to better mixing of air and fuel, minimizing emission levels specifically at swirl number of 1.4. (C) 2013 Elsevier Ltd. All rights reserved. C1 [Bhimani, Shreyas; Annamalai, Kalyan] Texas A&M Univ, Dept Mech Engn, College Stn, TX 77843 USA. [Alvarado, Jorge L.] Texas A&M Univ, Dept Engn Technol & Ind Distribut, College Stn, TX 77843 USA. [Marsh, Charles] US Army, Engn Res & Dev Ctr, Construct Engn Res Lab, Champaign, IL 61822 USA. [Marsh, Charles] Univ Illinois, Dept Nucl Plasma & Radiol Engn, Urbana, IL 61801 USA. RP Alvarado, JL (reprint author), 118C,Thompson Hall,MS 3367 TAMU, College Stn, TX 77843 USA. EM alvarado@entc.tamu.edu OI Alvarado, Jorge/0000-0002-4059-6588 NR 28 TC 7 Z9 7 U1 1 U2 6 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0016-2361 EI 1873-7153 J9 FUEL JI Fuel PD NOV PY 2013 VL 113 BP 97 EP 106 DI 10.1016/j.fuel.2013.04.083 PG 10 WC Energy & Fuels; Engineering, Chemical SC Energy & Fuels; Engineering GA 211UR UT WOS:000323937300012 ER PT J AU Mullins, KE Hang, J Jiang, J Leguia, M Kasper, MR Maguina, C Jarman, RG Blazes, DL Richards, AL AF Mullins, Kristin E. Hang, Jun Jiang, Ju Leguia, Mariana Kasper, Matthew R. Maguina, Ciro Jarman, Richard G. Blazes, David L. Richards, Allen L. TI Molecular Typing of "Candidatus Bartonella ancashi," a New Human Pathogen Causing Verruga Peruana SO JOURNAL OF CLINICAL MICROBIOLOGY LA English DT Article ID GENE; DIFFERENTIATION; CLASSIFICATION; SEQUENCES AB A recently described clinical isolate, "Candidatus Bartonella ancashi," was obtained from a blood sample of a patient presenting with verruga peruana in the Ancash region of Peru. This sample and a second isolate obtained 60 days later from the same patient were molecularly typed using multilocus sequence typing (MLST) and multispacer sequence typing (MST). The isolates were 100% indistinguishable from each other but phylogenetically distant from Bartonella bacilliformis and considerably divergent from other known Bartonella species, confirming their novelty. C1 [Mullins, Kristin E.; Blazes, David L.; Richards, Allen L.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [Mullins, Kristin E.; Jiang, Ju; Blazes, David L.; Richards, Allen L.] US Naval Med Res Ctr, Silver Spring, MD USA. [Hang, Jun; Jarman, Richard G.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Leguia, Mariana; Kasper, Matthew R.] US Naval Med Res, Unit 6, Lima, Peru. [Maguina, Ciro] Univ Peruana Cayetano Heredia, Lima, Peru. RP Richards, AL (reprint author), Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. EM Allen.Richards@med.navy.mil FU Global Emerging Infections Surveillance and Response System, a Division of the Armed Forces Health Surveillance Center [0000188 M.0931.001.A0074, I0361_12_WR]; Wellcome Trust [81828] FX This work was supported by the Global Emerging Infections Surveillance and Response System, a Division of the Armed Forces Health Surveillance Center (work unit number 0000188 M.0931.001.A0074 and grant number I0361_12_WR) and the Wellcome Trust (grant number 81828). NR 19 TC 9 Z9 10 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0095-1137 EI 1098-660X J9 J CLIN MICROBIOL JI J. Clin. Microbiol. PD NOV PY 2013 VL 51 IS 11 BP 3865 EP 3868 DI 10.1128/JCM.01226-13 PG 4 WC Microbiology SC Microbiology GA 236PT UT WOS:000325812200065 PM 23985925 ER PT J AU Woodberry, MW Shankar, R Cent, A Jerome, KR Kuypers, J AF Woodberry, Mitchell W. Shankar, Rohit Cent, Anne Jerome, Keith R. Kuypers, Jane TI Comparison of the Simplexa FluA/B & RSV Direct Assay and Laboratory-Developed Real-Time PCR Assays for Detection of Respiratory Virus SO JOURNAL OF CLINICAL MICROBIOLOGY LA English DT Article ID SYNCYTIAL VIRUS; INFLUENZA; SPECIMENS; TESTS; A/B AB The results of the Focus Simplexa FluA/B & RSV Direct assay were compared to those of laboratory-developed reverse transcription PCR tests for 498 nasopharyngeal swabs. Concordance rates were 96.6% (476/493; kappa = 0.91), 97.6% (481/493; kappa = 0.47), and 99.2% (488/492; kappa = 0.94) for influenza A, influenza B, and respiratory syncytial virus, respectively. C1 [Woodberry, Mitchell W.; Shankar, Rohit; Cent, Anne; Jerome, Keith R.; Kuypers, Jane] Univ Washington, Med Ctr, Dept Lab Med, Seattle, WA 98195 USA. [Woodberry, Mitchell W.] US Army, Ft Sam Houston, TX USA. RP Woodberry, MW (reprint author), Univ Washington, Med Ctr, Dept Lab Med, Seattle, WA 98195 USA. EM mitchell.w.woodberry@us.army.mil FU U.S. Army Long-term Health Education and Training program FX Mitchell W. Woodberry's fellowship was supported by the U.S. Army Long-term Health Education and Training program. NR 8 TC 11 Z9 11 U1 0 U2 2 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0095-1137 EI 1098-660X J9 J CLIN MICROBIOL JI J. Clin. Microbiol. PD NOV PY 2013 VL 51 IS 11 BP 3883 EP 3885 DI 10.1128/JCM.02395-13 PG 3 WC Microbiology SC Microbiology GA 236PT UT WOS:000325812200071 PM 24048529 ER PT J AU Chandler, ML AF Chandler, M. L. TI Psychotherapy for adult attention deficit/hyperactivity disorder: a comparison with cognitive behaviour therapy SO JOURNAL OF PSYCHIATRIC AND MENTAL HEALTH NURSING LA English DT Article DE behavioural interventions; cognitive and behavioural psychotherapy ID DEFICIT HYPERACTIVITY DISORDER; ADHD; PREVALENCE AB Attention deficit/hyperactivity disorder (ADHD), a disorder generally associated with children, has become a valid disorder for adults in the last decade. The first line treatment of adult ADHD is medications, but historically there have been limitations to medication as the only treatment. Psychotherapy has become a feasible modality in the treatment of ADHD for those who have residual symptoms. The aim of this review of literature is to compare cognitive behaviour therapy with other psychotherapeutic treatment for effectiveness in improving symptoms of ADHD in adults and adolescences. The evidence-based practice approach by Stillwell etal. is adopted to guide the systematic review. The use of this small evidence utilization project that led to a synthesis of available research will provide direction for future research and expand knowledge in treatment for adult ADHD. C1 [Chandler, M. L.] Uniformed Serv Univ Hlth Sci, US Army, Bethesda, MD 20814 USA. RP Chandler, ML (reprint author), 2401 Jones Bridge Rd, Bethesda, MD 20814 USA. EM mlchand@msn.com NR 30 TC 4 Z9 4 U1 3 U2 25 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1351-0126 EI 1365-2850 J9 J PSYCHIATR MENT HLT JI J. Psychiatr. Ment. Health Nurs. PD NOV PY 2013 VL 20 IS 9 BP 814 EP 820 DI 10.1111/jpm.12023 PG 7 WC Nursing; Psychiatry SC Nursing; Psychiatry GA 230VK UT WOS:000325371100008 PM 23506050 ER PT J AU El-Gabry, LA Thurman, DR Poinsatte, PE Heidmann, JD AF El-Gabry, Lamyaa A. Thurman, Douglas R. Poinsatte, Philip E. Heidmann, James D. TI Detailed Velocity and Turbulence Measurements in an Inclined Large-Scale Film Cooling Array SO JOURNAL OF TURBOMACHINERY-TRANSACTIONS OF THE ASME LA English DT Article DE film cooling; turbulence measurements; jet in crossflow; high blowing ID DENSITY RATIO; INJECTION; HOLES; JETS; FLOW; ROW AB A large-scale model of an inclined row of film cooling holes is used to obtain detailed surface and flow field measurements that will enable future computational fluid dynamics code development and validation. The model consists of three holes of 1.9-cm diameter that are spaced three hole diameters apart and inclined 30 deg from the surface. The length to diameter ratio of the coolant holes is about 18. Measurements include film effectiveness using IR thermography and near wall thermocouples, heat transfer using liquid crystal thermography, flow field temperatures using a thermocouple, and velocity and turbulence quantities using hotwire anemometry. Results are obtained for blowing ratios of up to 2 in order to capture severe conditions in which the jet is lifted. For purposes of comparison with prior art, measurements of the velocity and turbulence field along the jet centerline are made and compare favorably with two data sets in the open literature thereby verifying the test apparatus and methodology are able to replicate existing data sets. In addition, a computational fluid dynamics model using a two-equation turbulence model is developed, and the results for velocity, turbulent kinetic energy and turbulent dissipation rate are compared with experimentally derived quantities. C1 [El-Gabry, Lamyaa A.] Amer Univ Cairo, Dept Mech Engn, New Cairo 11835, Egypt. [Thurman, Douglas R.] Glenn Res Ctr, US Army Res Lab, Cleveland, OH 44135 USA. [Poinsatte, Philip E.; Heidmann, James D.] NASA, Glenn Res Ctr, Turbomachinery & Heat Transfer Branch, Cleveland, OH 44135 USA. RP El-Gabry, LA (reprint author), Amer Univ Cairo, Dept Mech Engn, New Cairo 11835, Egypt. EM lelgabry@aucegypt.edu FU NASA FX The research was carried out as part of the Subsonic Fixed Wing Project under NASA's Fundamental Aeronautics Program whose support is acknowledged. The authors would like to acknowledge the support of the NASA Glenn Faculty Fellowship program and the input of Dr. Khairul Zaman of NASA Glenn Research center on hotwire measurements. NR 19 TC 1 Z9 1 U1 0 U2 4 PU ASME PI NEW YORK PA TWO PARK AVE, NEW YORK, NY 10016-5990 USA SN 0889-504X EI 1528-8900 J9 J TURBOMACH JI J. Turbomach.-Trans. ASME PD NOV PY 2013 VL 135 IS 6 AR 061013 DI 10.1115/1.4023347 PG 11 WC Engineering, Mechanical SC Engineering GA 239KS UT WOS:000326023100013 ER PT J AU Copeland, AM Altamura, LA Van Deusen, NM Schmaljohn, CS AF Copeland, Anna Maria Altamura, Louis A. Van Deusen, Nicole M. Schmaljohn, Connie S. TI Nuclear Relocalization of Polyadenylate Binding Protein during Rift Valley Fever Virus Infection Involves Expression of the NSs Gene SO JOURNAL OF VIROLOGY LA English DT Article ID POLY(A)-BINDING PROTEIN; BIOCHEMICAL-CHARACTERIZATION; NONSTRUCTURAL PROTEIN; INITIATION-FACTOR; MOSQUITO CELLS; IN-VITRO; TRANSLATION; SEGMENT; IDENTIFICATION; REPLICATION AB Rift Valley fever virus (RVFV), an ambisense member of the family Bunyaviridae, genus Phlebovirus, is the causative agent of Rift Valley fever, an important zoonotic infection in Africa and the Middle East. Phlebovirus proteins are translated from virally transcribed mRNAs that, like host mRNA, are capped but, unlike host mRNAs, are not polyadenylated. Here, we investigated the role of PABP1 during RVFV infection of HeLa cells. Immunofluorescence studies of infected cells demonstrated a gross relocalization of PABP1 to the nucleus late in infection. Immunofluorescence microscopy studies of nuclear proteins revealed costaining between PABP1 and markers of nuclear speckles. PABP1 relocalization was sharply decreased in cells infected with a strain of RVFV lacking the gene encoding the RVFV nonstructural protein S (NSs). To determine whether PABP1 was required for RVFV infection, we measured the production of nucleocapsid protein (N) in cells transfected with small interfering RNAs (siRNAs) targeting PABP1. We found that the overall percentage of RVFV N-positive cells was not changed by siRNA treatment, indicating that PABP1 was not required for RVFV infection. However, when we analyzed populations of cells producing high versus low levels of PABP1, we found that the percentage of RVFV N-positive cells was decreased in cell populations producing physiologic levels of PABP1 and increased in cells with reduced levels of PABP1. Together, these results suggest that production of the NSs protein during RVFV infection leads to sequestration of PABP1 in the nuclear speckles, creating a state within the cell that favors viral protein production. C1 [Copeland, Anna Maria; Altamura, Louis A.; Van Deusen, Nicole M.; Schmaljohn, Connie S.] United States Army, Med Res Inst Infect Dis, Frederick, MD USA. RP Schmaljohn, CS (reprint author), United States Army, Med Res Inst Infect Dis, Frederick, MD USA. EM Connie.s.schmaljohn.civ@mail.mil FU Defense Threat Reduction Agency; National Academy of Sciences FX This work was funded by the Defense Threat Reduction Agency and the National Academy of Sciences. The research was performed while Anna Maria Copeland held a National Academy of Sciences National Research Council Associateship. NR 63 TC 6 Z9 6 U1 0 U2 10 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0022-538X EI 1098-5514 J9 J VIROL JI J. Virol. PD NOV PY 2013 VL 87 IS 21 BP 11659 EP 11669 DI 10.1128/JVI.01434-13 PG 11 WC Virology SC Virology GA 237IR UT WOS:000325863400030 PM 23966414 ER PT J AU Kuperman, RG Checkai, RT Simini, M Phillips, CT Kolakowski, JE Lannoz, R AF Kuperman, Roman G. Checkai, Ronald T. Simini, Michael Phillips, Carlton T. Kolakowski, Jan E. Lannoz, Roman TI SOIL PROPERTIES AFFECT THE TOXICITIES OF 2,4,6-TRINITROTOLUENE (TNT) AND HEXAHYDRO-1,3,5-TRINITRO-1,3,5-TRIAZINE (RDX) TO THE ENCHYTRAEID WORM ENCHYTRAEUS CRYPTICUS SO ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY LA English DT Article DE 2; 4; 6-Trinitrotoluene (TNT); Hexahydro-1; 3; 5-trinitro-1; 3; 5-triazine (RDX); Explosives toxicity; Soil; Potworm Enchytraeus crypticus ID EARTHWORM EISENIA-ANDREI; SANDY LOAM SOIL; HETEROCYCLIC EXPLOSIVES RDX; ENERGETIC COMPOUNDS; ORGANIC-CARBON; FOREST SOIL; REPRODUCTION; METABOLITES; BIOTRANSFORMATION; SORPTION AB The authors investigated individual toxicities of 2,4,6-trinitrotoluene (TNT) and hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) to the potworm Enchytraeus crypticus using the enchytraeid reproduction test. Studies were designed to generate ecotoxicological benchmarks that can be used for developing ecological soil-screening levels for ecological risk assessments of contaminated soils and to identify and characterize the predominant soil physicochemical parameters that can affect the toxicities of TNT and RDX to E. crypticus. Soils, which had a wide range of physicochemical parameters, included Teller sandy loam, Sassafras sandy loam, Richfield clay loam, Kirkland clay loam, and Webster clay loam. Analyses of quantitative relationships between the toxicological benchmarks for TNT and soil property measurements identified soil organic matter content as the dominant property mitigating TNT toxicity for juvenile production by E. crypticus in freshly amended soil. Both the clay and organic matter contents of the soil modulated reproduction toxicity of TNT that was weathered and aged in soil for 3 mo. Toxicity of RDX for E. crypticus was greater in the coarse-textured sandy loam soils compared with the fine-textured clay loam soils. The present studies revealed alterations in toxicity to E. crypticus after weathering and aging TNT in soil, and these alterations were soil- and endpoint-specific. Environ Toxicol Chem 2013;32:2648-2659. (c) 2013 SETAC C1 [Kuperman, Roman G.; Checkai, Ronald T.; Simini, Michael; Phillips, Carlton T.; Kolakowski, Jan E.] US Army Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD USA. [Lannoz, Roman] Ohio State Univ, Dept Ecol Evolut & Organismal Biol, Columbus, OH 43210 USA. RP Kuperman, RG (reprint author), US Army Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD USA. EM roman.g.kuperman.civ@mail.mil FU Strategic Environmental Research and Development Program (Arlington, VA, USA) FX The authors thank G. Sunahara and J. Hawari from the National Research Council of Canada for their contributions of methodology development, interlaboratory participation in quality-control and quality-assurance measures for analytical determinations of RDX and TNT, data exchange during execution of the present study, and valuable comments on an earlier draft of the article. The present project was completed in cooperation with and with funding from the Strategic Environmental Research and Development Program (Arlington, VA, USA). NR 54 TC 4 Z9 4 U1 3 U2 20 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0730-7268 EI 1552-8618 J9 ENVIRON TOXICOL CHEM JI Environ. Toxicol. Chem. PD NOV PY 2013 VL 32 IS 11 BP 2648 EP 2659 DI 10.1002/etc.2356 PG 12 WC Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA 232HE UT WOS:000325482700028 PM 23955807 ER PT J AU Nindl, BC Castellani, JW Warr, BJ Sharp, MA Henning, PC Spiering, BA Scofield, DE AF Nindl, Bradley C. Castellani, John W. Warr, Bradley J. Sharp, Marilyn A. Henning, Paul C. Spiering, Barry A. Scofield, Dennis E. TI Physiological Employment Standards III: physiological challenges and consequences encountered during international military deployments SO EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY LA English DT Review DE Physical performance; Musculoskeletal injury; Load carriage; Traumatic brain injury; Post-traumatic stress disorder ID OPERATION-IRAQI-FREEDOM; COLD-INDUCED VASODILATION; TRAUMATIC BRAIN-INJURY; BRIGADE COMBAT TEAM; SKIN BLOOD-FLOW; AIR BURN PITS; ENDURING-FREEDOM; RESPIRATORY HEALTH; US ARMY; AEROBIC PERFORMANCE AB Modern international military deployments in austere environments (i.e., Iraq and Afghanistan) place considerable physiological demands on soldiers. Significant physiological challenges exist: maintenance of physical fitness and body composition, rigors of external load carriage, environmental extremes (heat, cold, and altitude), medical illnesses, musculoskeletal injuries, traumatic brain injuries, post-traumatic stress disorder, and environmental exposure hazards (i.e., burn pits, vehicle exhaust, etc.). To date there is very little published research and no comprehensive reviews on the physiological effects of deployments. The purpose of this paper is to overview what is currently known from the literature related mainly to current military conflicts with regard to the challenges and consequences from deployments. Summary findings include: (1) aerobic capacity declines while muscle strength, power and muscular endurance appear to be maintained, (2) load carriage continues to tax the physical capacities of the Soldier, (3) musculoskeletal injuries comprise the highest proportion of all injury categories, (4) environmental insults occur from both terrestrial extremes and pollutant exposure, and (5) post-deployment concerns linger for traumatic brain injury and post-traumatic stress disorder. A full understanding of these responses will assist in identifying the most effective risk mitigation strategies to ensure deployment readiness and to assist in establishment of military employment standards. C1 [Nindl, Bradley C.] Army Publ Hlth Command, Army Inst Publ Hlth, Aberdeen, MD 21010 USA. [Castellani, John W.] US Army Res Inst Environm Med, Thermal & Mt Med Div, Natick, MA 01760 USA. [Warr, Bradley J.; Sharp, Marilyn A.; Henning, Paul C.; Spiering, Barry A.; Scofield, Dennis E.] US Army Res Inst Environm Med, Mil Performance Div, Natick, MA 01760 USA. RP Nindl, BC (reprint author), Army Publ Hlth Command, Army Inst Publ Hlth, Aberdeen, MD 21010 USA. EM bradley.nindl@us.army.mil RI SCOFIELD, DENNIS/F-3636-2015 NR 110 TC 19 Z9 21 U1 9 U2 42 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1439-6319 EI 1439-6327 J9 EUR J APPL PHYSIOL JI Eur. J. Appl. Physiol. PD NOV PY 2013 VL 113 IS 11 BP 2655 EP 2672 DI 10.1007/s00421-013-2591-1 PG 18 WC Physiology; Sport Sciences SC Physiology; Sport Sciences GA 236EZ UT WOS:000325778900001 PM 23430237 ER PT J AU Costiner, S Winston, HA Gurvich, MR Ghoshal, A Welsh, GS Butler, SL Urban, MR Bordick, N AF Costiner, Sorin Winston, Howard A. Gurvich, Mark R. Ghoshal, Anindya Welsh, Gregory S. Butler, Shaoluo L. Urban, Michael R. Bordick, Nathaniel TI A probabilistic hybrid sensor fusion and optimization approach for aircraft composite components SO JOURNAL OF INTELLIGENT MATERIAL SYSTEMS AND STRUCTURES LA English DT Article DE Structural health monitoring; piezoelectric lead zirconate titanate sensor; fiber Bragg grating sensors; hybrid sensor fusion; sensor optimization; global optimization; probabilistic sensor fusion; optimal sensor fusion ID DAMAGE DETECTION; LOCATION AB An integrated sensor system that continuously monitors the structural integrity of an aircraft's critical composite components can have a high payoff by reducing risks, costs, inspections, and unscheduled maintenance, while increasing safety. Hybrid sensor networks combine or fuse different types of sensors. Optimal sensor fusion tries to find the optimal number and location of different types of sensors such that their combined probability of detection is maximized. Optimal hybrid sensor networks can be more robust, more accurate, and/or cheaper than networks consisting only of homogeneous sensors. A generic sensor fusion approach that combines the probabilities of detection of heterogeneous sensors is described. A fast greedy optimization approach that provides approximate solutions is described and demonstrated. Computable lower and upper bounds of a probability of detection objective function were determined. Fiber Bragg grating sensors can be inserted in layers of composite structures to provide local damage detection, while surface-mounted piezoelectric lead zirconate titanate sensors can provide global damage detection for the host structure under consideration. The generic approach is demonstrated on such combinations of fiber Bragg grating and lead zirconate titanate sensor networks. It is demonstrated that the proposed approach can be used to answer structural health monitoring network design problems such as the following: (1) Given a number of sensors, what is the maximum probability of detection that the sensors can attain and where should they be positioned to provide the maximum probability of detection? (2) If a given probability of detection is desired, the minimum number, types, and locations of sensors that are needed to attain this probability of detection can be determined. The approach is generic, that is, it can be extended to any number or types of sensors for which probabilities of detection can be defined. C1 [Costiner, Sorin; Winston, Howard A.; Gurvich, Mark R.; Welsh, Gregory S.; Butler, Shaoluo L.] United Technol Res Ctr, E Hartford, CT 06108 USA. [Ghoshal, Anindya] US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA. [Urban, Michael R.] Sikorsky Aircraft Corp, Stratford, CT USA. [Bordick, Nathaniel] Army AATD, Ft Eustis, VA USA. RP Ghoshal, A (reprint author), US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA. EM anindo_ghoshal@yahoo.com FU US government [W911W6-08-2-0002] FX This research was partially funded by the US government under agreement no. W911W6-08-2-0002. NR 36 TC 2 Z9 2 U1 1 U2 10 PU SAGE PUBLICATIONS LTD PI LONDON PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND SN 1045-389X EI 1530-8138 J9 J INTEL MAT SYST STR JI J. Intell. Mater. Syst. Struct. PD NOV PY 2013 VL 24 IS 17 SI SI BP 2110 EP 2134 DI 10.1177/1045389X12460432 PG 25 WC Materials Science, Multidisciplinary SC Materials Science GA 235HF UT WOS:000325707100006 ER PT J AU Wallin, M Aboubakr, AK Jayakumar, P Letherwood, MD Gorsich, DJ Hamed, A Shabana, AA AF Wallin, Michael Aboubakr, Ahmed K. Jayakumar, Paramsothy Letherwood, Michael D. Gorsich, David J. Hamed, Ashraf Shabana, Ahmed A. TI A comparative study of joint formulations: application to multibody system tracked vehicles SO NONLINEAR DYNAMICS LA English DT Article DE Multibody system dynamics; Joint formulations; Joint compliance; Penalty method; Bushing elements; Tracked vehicles; ANCF finite elements ID PART I; DYNAMICS; MODEL; CONSTRAINTS; SIMULATION; CONTACT AB This paper is focused on the dynamic formulation of mechanical joints using different approaches that lead to different models with different numbers of degrees of freedom. Some of these formulations allow for capturing the joint deformations using a discrete elastic model while the others are continuum-based and capture joint deformation modes that cannot be captured using the discrete elastic joint models. Specifically, three types of joint formulations are considered in this investigation; the ideal, compliant discrete element, and compliant continuum-based joint models. The ideal joint formulation, which does not allow for deformation degrees of freedom in the case of rigid body or small deformation analysis, requires introducing a set of algebraic constraint equations that can be handled in computational multibody system (MBS) algorithms using two fundamentally different approaches: constrained dynamics approach and penalty method. When the constrained dynamics approach is used, the constraint equations must be satisfied at the position, velocity, and acceleration levels. The penalty method, on the other hand, ensures that the algebraic equations are satisfied at the position level only. In the compliant discrete element joint formulation, no constraint conditions are used; instead the connectivity conditions between bodies are enforced using forces that can be defined in their most general form in MBS algorithms using bushing elements that allow for the definition of general nonlinear forces and moments. The new compliant continuum-based joint formulation, which is based on the finite element (FE) absolute nodal coordinate formulation (ANCF), has several advantages: (1) It captures modes of joint deformations that cannot be captured using the compliant discrete joint models; (2) It leads to linear connectivity conditions, thereby allowing for the elimination of the dependent variables at a preprocessing stage; (3) It leads to a constant inertia matrix in the case of chain like structure; and (4) It automatically captures the deformation of the bodies using distributed inertia and elasticity. The formulations of these three different joint models are compared in order to shed light on the fundamental differences between them. Numerical results of a detailed tracked vehicle model are presented in order to demonstrate the implementation of some of the formulations discussed in this investigation. C1 [Wallin, Michael; Aboubakr, Ahmed K.; Hamed, Ashraf; Shabana, Ahmed A.] Univ Illinois, Dept Mech & Ind Engn, Chicago, IL 60607 USA. [Jayakumar, Paramsothy; Letherwood, Michael D.; Gorsich, David J.] US Army TARDEC, Warren, MI 48397 USA. RP Shabana, AA (reprint author), Univ Illinois, Dept Mech & Ind Engn, 842 West Taylor St, Chicago, IL 60607 USA. EM shabana@uic.edu FU US Army Tank-Automotive Research, Development, and Engineering Center (TARDEC) [W911NF-07-D-0001] FX This research was supported by the US Army Tank-Automotive Research, Development, and Engineering Center (TARDEC) (Contract No. W911NF-07-D-0001). NR 21 TC 4 Z9 4 U1 0 U2 18 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0924-090X EI 1573-269X J9 NONLINEAR DYNAM JI Nonlinear Dyn. PD NOV PY 2013 VL 74 IS 3 BP 783 EP 800 DI 10.1007/s11071-013-1005-6 PG 18 WC Engineering, Mechanical; Mechanics SC Engineering; Mechanics GA 236UM UT WOS:000325824900023 ER PT J AU Kim, Y Blank, S AF Kim, Younkyoo Blank, Stephen TI Insurgency and Counterinsurgency in Russia: Contending Paradigms and Current Perspectives SO STUDIES IN CONFLICT & TERRORISM LA English DT Article AB The most outstanding trend in contemporary conflicts has been the fusion of the threats from terrorism and insurgency. Insurgent threats in many places on the globe today are mistaken as terrorist threats, and counterterrorism (CT) is deployed as the local insurgents come increasingly to resemble their transnational terrorist partners. Such an emphasis on the role of terrorism in insurgencies and the undue focus on CT risks strengthening, rather than severing, the connection between local insurgents and transnational terrorists. Russia's counterterrorist strategy inadvertently transformed the conflict from a contained, nationalist rebellion to a sprawling jihadi insurgency and perversely encouraged the group to resort even more to terrorist tactics. The Russian counterinsurgency has been unsuccessful, as the insurgents are neither demolished as a force nor are they isolated by society. Losing the hearts and minds among the Chechen people is a key reason behind why the Russian operation in Chechnya suffered failures. Too little attention was paid to winning over the hearts and minds of the people. C1 [Kim, Younkyoo] Hanyang Univ, Div Int Studies, Seoul 133791, South Korea. [Blank, Stephen] US Army War Coll, Strateg Studies Inst, Carlisle, PA USA. RP Kim, Y (reprint author), Hanyang Univ, Div Int Studies, Seoul 133791, South Korea. EM YOUN2302@hanyang.ac.kr NR 42 TC 2 Z9 2 U1 2 U2 14 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA SN 1057-610X EI 1521-0731 J9 STUD CONFL TERROR JI Stud. Confl. Terror. PD NOV 1 PY 2013 VL 36 IS 11 BP 917 EP 932 DI 10.1080/1057610X.2013.832115 PG 16 WC International Relations; Political Science SC International Relations; Government & Law GA 232SQ UT WOS:000325514700004 ER PT J AU McKee, CJ Hines, HB Ulrich, RG AF McKee, Christopher J. Hines, Harry B. Ulrich, Robert G. TI Analysis of protein tyrosine phosphatase interactions with microarrayed phosphopeptide substrates using imaging mass spectrometry SO ANALYTICAL BIOCHEMISTRY LA English DT Article DE MALDI; Imaging mass spectrometry; Peptide microarray; YopH; Phosphatase assay; SPRi ID YOPH; IDENTIFICATION; SPECIFICITY AB Microarrays of peptide and recombinant protein libraries are routinely used for high-throughput studies of protein-protein interactions and enzymatic activities. Imaging mass spectrometry (IMS) is currently applied as a method to localize analytes on thin tissue sections and other surfaces. Here, we have applied IMS as a label-free means to analyze protein-peptide interactions in a microarray-based phosphatase assay. This IMS strategy visualizes the entire microarray in one composite image by collecting a predefined raster of matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry spectra over the surface of the chip. Examining the bacterial tyrosine phosphatase YopH, we used IMS as a label-free means to visualize enzyme binding and activity with a microarrayed phosphopeptide library printed on chips coated with either gold or indium-tin oxide. Furthermore, we demonstrate that microarray-based IMS can be coupled with surface plasmon resonance imaging to add kinetic analyses to measured binding interactions. The method described here is within the capabilities of many modern MALDI-TOF instruments and has general utility for the label-free analysis of microarray assays. Published by Elsevier Inc. C1 [McKee, Christopher J.; Hines, Harry B.; Ulrich, Robert G.] US Army Med Res Inst Infect Dis, Frederick, MD 21702 USA. RP McKee, CJ (reprint author), US Army Med Res Inst Infect Dis, Frederick, MD 21702 USA. EM mckee.473@buckeyemail.osu.edu FU National Institute of Allergy and Immunology [R01AI096215]; Defense Threat Reduction Agency at the U.S. Army Medical Research Institute for Infectious Disease FX The authors acknowledge Mohan Natesan, Megan Hogan, and Bryan M. Zhao for critical discussions and evaluation of the manuscript and acknowledge Dave Waugh (National Cancer Institute-Frederick National Laboratories) for providing the recombinant YopH proteins. This research was funded by the National Institute of Allergy and Immunology (R01AI096215) and performed while CJ.M. held a National Research Council research associateship awarded by the Defense Threat Reduction Agency at the U.S. Army Medical Research Institute for Infectious Disease. The content does not necessarily reflect the position or policy of the federal government, and no official endorsement should be inferred. NR 16 TC 1 Z9 1 U1 1 U2 27 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0003-2697 J9 ANAL BIOCHEM JI Anal. Biochem. PD NOV 1 PY 2013 VL 442 IS 1 BP 62 EP 67 DI 10.1016/j.ab.2013.07.031 PG 6 WC Biochemical Research Methods; Biochemistry & Molecular Biology; Chemistry, Analytical SC Biochemistry & Molecular Biology; Chemistry GA 225OL UT WOS:000324972100008 PM 23906642 ER PT J AU Vecherin, SN Ostashev, VE Fairall, CW Wilson, DK Bariteau, L AF Vecherin, Sergey N. Ostashev, Vladimir E. Fairall, Christopher W. Wilson, D. Keith Bariteau, Ludovic TI Sonic Anemometer as a Small Acoustic Tomography Array SO BOUNDARY-LAYER METEOROLOGY LA English DT Article DE Acoustic tomography; Small-scale turbulence; Sonic anemometer ID ATMOSPHERIC SURFACE-LAYER; TRAVEL-TIME TOMOGRAPHY AB The spatial resolution of a sonic anemometer is limited by the distance between its transducers, and for studies of small-scale turbulence and theories of turbulence, it is desirable to increase this spatial resolution. We here consider resolution improvements obtainable by treating the sonic anemometer as a small tomography array, with application of appropriate inverse algorithms for the reconstruction of temperature and velocity. A particular modification of the sonic anemometer is considered when the number of its transducers is doubled and the time-dependent stochastic inversion algorithm is used for reconstruction. Numerical simulations of the sonic anemometer and its suggested modification are implemented with the temperature and velocity fields modelled as discrete eddies moving through the sonic's volume. The tomographic approach is shown to provide better reconstructions of the temperature and velocity fields, with spatial resolution increased by as much as a factor of ten. The spatial resolution depends on the inverse algorithm and also improves by increasing the number of transducers. C1 [Vecherin, Sergey N.; Wilson, D. Keith] US Army Engn Res & Dev Ctr, Hanover, NH USA. [Ostashev, Vladimir E.; Bariteau, Ludovic] Univ Colorado, Cooperat Inst Res Environm Sci, Boulder, CO 80305 USA. [Fairall, Christopher W.] NOAA Earth Syst Res Lab, Boulder, CO 80305 USA. RP Ostashev, VE (reprint author), Univ Colorado, Cooperat Inst Res Environm Sci, 325 Broadway, Boulder, CO 80305 USA. EM Sergey.N.Vecherin@erdc.dren.mil; vladimir.ostashev@noaa.gov RI Wilson, D. Keith/A-4687-2012 OI Wilson, D. Keith/0000-0002-8020-6871 FU U. S. Army Research Laboratory; U. S. Army Research Office [W911NF1010415] FX This material is based upon work supported in part by the U. S. Army Research Laboratory and the U. S. Army Research Office under contract/grant number W911NF1010415 to Dr. Ostashev. Permission to publish was granted by Director, Cold Regions Research and Engineering Laboratory. We would like to thank two anonymous reviewers whose comments allowed us to improve the paper. NR 13 TC 0 Z9 0 U1 0 U2 16 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0006-8314 J9 BOUND-LAY METEOROL JI Bound.-Layer Meteor. PD NOV PY 2013 VL 149 IS 2 BP 165 EP 178 DI 10.1007/s10546-013-9843-9 PG 14 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA 228XG UT WOS:000325224800002 ER PT J AU Jansen, JO Morrison, JJ AF Jansen, J. O. Morrison, J. J. TI Mortality from trauma in Scotland SO INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED LA English DT Editorial Material ID FUNCTIONAL OUTCOMES; QUALITY; CARE; SYSTEM C1 [Jansen, J. O.] Aberdeen Royal Infirm, Aberdeen AB25 2ZN, Scotland. [Morrison, J. J.] New Queen Elizabeth Hosp, Natl Inst Hlth Res, Birmingham, W Midlands, England. [Morrison, J. J.] US Army Inst Surg Res, Ft Sam Houston, TX USA. RP Jansen, JO (reprint author), Aberdeen Royal Infirm, Foresterhill, Aberdeen AB25 2ZN, Scotland. EM j.o.jansen@gmx.com OI Morrison, Jonathan/0000-0001-7462-8456 NR 15 TC 1 Z9 1 U1 0 U2 3 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0020-1383 J9 INJURY JI Injury-Int. J. Care Inj. PD NOV PY 2013 VL 44 IS 11 BP 1377 EP 1378 DI 10.1016/j.injury.2012.08.058 PG 2 WC Critical Care Medicine; Emergency Medicine; Orthopedics; Surgery SC General & Internal Medicine; Emergency Medicine; Orthopedics; Surgery GA 227ZT UT WOS:000325155000001 PM 22995982 ER PT J AU Abed, KH Morris, GR AF Abed, Khalid H. Morris, Gerald R. TI Improving performance of codes with large/irregular stride memory access patterns via high performance reconfigurable computers SO JOURNAL OF PARALLEL AND DISTRIBUTED COMPUTING LA English DT Article DE High performance computing; Heterogeneous computer; Reconfigurable computer; FPGA; Irregular memory access pattern ID FLOATING-POINT DATA; HETEROGENEOUS COMPUTER; SETS AB Codes that have large-stride/irregular-stride (L/I) memory access patterns, e.g., sparse matrix and linked list codes, often perform poorly on mainstream clusters because of the general purpose processor (GPP) memory hierarchy. High performance reconfigurable computers (HPRC) contain both GPPs and field programmable gate arrays (FPGAs) connected via a high-speed network. In this research, simple 64-bit floating-point codes are used to illustrate the runtime performance impact of L/I memory accesses in both software-only and FPGA-augmented codes and to assess the benefits of mapping L/I-type codes onto HPRCs. The experiments documented herein reveal that large-stride software-only codes experience severe performance degradation. In contrast, large-stride FPGA-augmented codes experience minimal performance degradation. For experiments with large data sizes, the unit-stride FPGA-augmented code ran about two times slower than software. On the other hand, the large-stride FPGA-augmented code ran faster than software for all the larger data sizes. The largest showed a 17-fold runtime speedup. (C) 2012 Elsevier Inc. All rights reserved. C1 [Abed, Khalid H.] Jackson State Univ, Sch Engn, Dept Comp Engn, Jackson, MS 39217 USA. [Morris, Gerald R.] Res Ctr Comp Sci, Ctr Res & Dev, Vicksburg, MS 39180 USA. RP Abed, KH (reprint author), Jackson State Univ, Sch Engn, Dept Comp Engn, 1400 JR Lynch St, Jackson, MS 39217 USA. EM khalid.h.abed@jsums.edu; gerald.r.morris@us.army.mil OI Abed, Khalid/0000-0002-5203-2907 FU U.S. Department of Defense High Performance Computing Modernization Program under the U.S. Army Engineer Research and Development Center (ERDC) [W912HZ-10-C-0107] FX This work was supported in part by the U.S. Department of Defense High Performance Computing Modernization Program under the U.S. Army Engineer Research and Development Center (ERDC) contract no. W912HZ-10-C-0107 entitled "High Performance Computational Design of Novel Materials". NR 31 TC 0 Z9 0 U1 0 U2 3 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0743-7315 J9 J PARALLEL DISTR COM JI J. Parallel Distrib. Comput. PD NOV PY 2013 VL 73 IS 11 SI SI BP 1430 EP 1438 DI 10.1016/j.jpdc.2012.07.011 PG 9 WC Computer Science, Theory & Methods SC Computer Science GA 231VS UT WOS:000325447100003 ER PT J AU Smither, SJ Lear-Rooney, C Biggins, J Pettitt, J Lever, MS Olinger, GG AF Smither, Sophie J. Lear-Rooney, Calli Biggins, Julia Pettitt, Jamie Lever, Mark S. Olinger, Gene G., Jr. TI Comparison of the plaque assay and 50% tissue culture infectious dose assay as methods for measuring filovirus infectivity SO JOURNAL OF VIROLOGICAL METHODS LA English DT Article DE Filoviruses; Counting; Assays; Plaque; Tissue culture infectious dose ID HEMORRHAGIC-FEVER; VIRUS; PATHOGENESIS; SURVIVAL; AEROSOL; EBOLA AB Two common methods of quantifying filovirus infectivity, a plaque assay and 50% cell culture infectious dose (TCID50) endpoint dilution assay, were compared. The two assays were performed side by side using the same virus stock sample to determine the correlation between the results of the two assays. The TCID50 assay appeared to be more sensitive but slightly more variable, and there was a tenfold difference in the numerical results of these methods of enumeration. The advantages and disadvantages of both assays are discussed. Both methods are useful and practicable in filovirus research, and this comparison will be hugely beneficial to the filovirus research community as it seeks to become more united. Further work in this area should be performed to ensure consistency in filovirus research. (C) 2013 Published by Elsevier B.V. C1 [Smither, Sophie J.; Lever, Mark S.] Def Sci & Technol Lab, Dept Biomed Sci, Salisbury SP4 0JQ, Wilts, England. [Lear-Rooney, Calli; Biggins, Julia; Pettitt, Jamie; Olinger, Gene G., Jr.] US Army Med Res Inst Infect Dis, Div Virol, Frederick, MD 21701 USA. RP Olinger, GG (reprint author), US Army Med Res Inst Infect Dis, Div Virol, 1425 Porter St, Frederick, MD 21702 USA. EM sjsmither@dstl.gov.uk; calli.m.lear.civ@mail.mil; julia.e.biggins.ctr@mail.mil; james.d.pettitt.ctr@mail.mil; mslever@dstl.gov.uk; gene.g.olinger2.civ@mail.mil FU U.S. Department of Defense; Defense Threat Reduction Agency (DTRA); UK Ministry of Defence FX The research described herein was sponsored by the U.S. Department of Defense, the Defense Threat Reduction Agency (DTRA), and by the UK Ministry of Defence. NR 18 TC 12 Z9 13 U1 2 U2 20 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0166-0934 J9 J VIROL METHODS JI J. Virol. Methods PD NOV PY 2013 VL 193 IS 2 BP 565 EP 571 DI 10.1016/j.jviromet.2013.05.015 PG 7 WC Biochemical Research Methods; Biotechnology & Applied Microbiology; Virology SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology; Virology GA 228MH UT WOS:000325190400052 PM 23748121 ER PT J AU Pozuelo, M Mathaudhu, SN Kim, S Li, B Kao, WH Yang, JM AF Pozuelo, M. Mathaudhu, S. N. Kim, S. Li, B. Kao, W. H. Yang, J. -M. TI Nanotwins in nanocrystalline Mg-Al alloys: an insight from high-resolution TEM and molecular dynamics simulation SO PHILOSOPHICAL MAGAZINE LETTERS LA English DT Article DE nanocrystalline Mg-Al alloys; nanotwins; cryomilling; transmission electron microscopy; molecular dynamics simulations ID POLYCRYSTALLINE MAGNESIUM ALLOY; GRAIN-SIZE; DEFORMATION-BEHAVIOR; NANOSTRUCTURED MATERIALS; ROOM-TEMPERATURE; METALS; NUCLEATION; DEPENDENCE; TWINS AB Twinning in hexagonal close-packed Mg alloys has been reported to be unfavorable when the grain size is reduced below a couple of microns and suppressed at the nanoscale. Using high-resolution transmission electron microscopy, we present evidence of nanotwins (<1nm) in nanocrystalline Mg-Al alloys processed by cryomilling. The commonly observed twinning modes for coarse-grained Mg are identified and supported with atomistic molecular dynamics simulations. The specific thermomechanical conditions offered by cryomilling facilitate the generation of deformation twins that are not observed with conventional deformation processing methods. C1 [Pozuelo, M.; Yang, J. -M.] Univ Calif Los Angeles, Dept Mat Sci & Engn, Los Angeles, CA 90095 USA. [Mathaudhu, S. N.] US Army Res Lab, Weapons & Mat Res Directorate, Aberdeen, MD 21005 USA. [Kim, S.; Li, B.] Mississippi State Univ, Ctr Adv Vehicular Syst, Mississippi State, MS 39762 USA. [Kao, W. H.] Univ Calif Los Angeles, Inst Technol Adv, Los Angeles, CA 90095 USA. RP Pozuelo, M (reprint author), Univ Calif Los Angeles, Dept Mat Sci & Engn, Los Angeles, CA 90095 USA. EM pozuelo@ucla.edu RI Mathaudhu, Suveen/B-4192-2009; , Marta/A-6906-2011 OI , Marta/0000-0001-6869-8749 FU Army Research Office under the ARO Contract [W911NF-09-1-0558] FX The authors express their appreciation to the Army Research Office for financial support of this work under the ARO Contract No. W911NF-09-1-0558. They are particularly grateful to the ARO program manager, Dr Larry Russell and to Christopher Melnyk for his assistance with the cryomilling performed at California Nanotechnologies Inc. NR 39 TC 7 Z9 8 U1 3 U2 45 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 0950-0839 J9 PHIL MAG LETT JI Philos. Mag. Lett. PD NOV 1 PY 2013 VL 93 IS 11 BP 640 EP 647 DI 10.1080/09500839.2013.833353 PG 8 WC Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering; Physics, Applied; Physics, Condensed Matter SC Materials Science; Metallurgy & Metallurgical Engineering; Physics GA 228PD UT WOS:000325197800004 ER PT J AU McWilliams, BA Ramesh, KT Yen, CF AF McWilliams, Brandon A. Ramesh, K. T. Yen, Chian-Fong TI Probabilistic response of heterogeneous particle reinforced metal matrix composites with particle size dependent strengthening SO COMPUTATIONAL MATERIALS SCIENCE LA English DT Article DE Probabilistic material response; Finite element method; Metal matrix composites ID REPRESENTATIVE VOLUME ELEMENT; STRAIN-GRADIENT PLASTICITY; DEFORMATION-BEHAVIOR; ALUMINUM; FRACTURE; STRESS AB This paper presents an enhanced continuum model for a heterogeneous particle arrangement to simulate the variability in the size dependent strengthening of silicon carbide (SiC) ceramic particle reinforced metal matrix composites (MMCs). The model incorporates a size dependent "punched" zone around the particles that is the result of a local increase in dislocation density during thermal processing due to geometrically necessary dislocations generated by the mismatch in coefficients of thermal expansion of the particle and matrix. In this work, these zones are explicitly accounted for in finite element simulations of multiple realizations of representative heterogeneous composite microstructures consisting of randomly distributed particles in a metal matrix. This modeling approach is used to capture the probabilistic response of the material which is linked to stochastic variations in the local microstructure of the material. The model is then used to explore the effects of particle size and volume fraction on the variability of the inelastic deformation response of heterogeneous MMCs. It is shown that the variance of the composite response increases as the particle size decreases and as the volume fraction of reinforcing particles increases. It is also shown that the amount of strain localization in the matrix increases as the particle size decreases. (C) 2013 Elsevier B. V. All rights reserved. C1 [McWilliams, Brandon A.; Yen, Chian-Fong] US Army Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD USA. [Ramesh, K. T.] Johns Hopkins Univ, Ctr Adv Metall & Ceram Syst, Baltimore, MD USA. RP McWilliams, BA (reprint author), ATTN, WMM B, Build 4600, Aberdeen Proving Ground, MD 21005 USA. EM brandon.a.mcwilliams.ctr@mail.mil FU U.S. Army Research Laboratory; Army Research Laboratory under the ARMAC-RTP [W911NF-06-2-0006] FX The authors would like to acknowledge Prof. Lori Graham-Brady at Johns Hopkins University for technical guidance regarding the statistical nature of heterogeneous materials. Brandon McWilliams was supported in part by an appointment to the Postgraduate Research Participation Program at the U.S. Army Research Laboratory administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the U.S. Department of Energy and USARL. K. T. Ramesh was supported by the Army Research Laboratory under the ARMAC-RTP Cooperative Agreement No. W911NF-06-2-0006. NR 33 TC 5 Z9 5 U1 0 U2 18 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0927-0256 EI 1879-0801 J9 COMP MATER SCI JI Comput. Mater. Sci. PD NOV PY 2013 VL 79 BP 15 EP 24 DI 10.1016/j.commatsci.2013.05.047 PG 10 WC Materials Science, Multidisciplinary SC Materials Science GA 218ZE UT WOS:000324471100002 ER PT J AU Nordendale, NA Heard, WF Hickman, MA Zhang, B Basu, PK AF Nordendale, N. A. Heard, W. F. Hickman, M. A. Zhang, B. Basu, P. K. TI Cementitious material models for simulating projectile impact effects SO COMPUTATIONAL MATERIALS SCIENCE LA English DT Article DE Ballistic; Impact; Cementitious; Material; Modeling; Experiment AB Digital simulation of structural components of brittle cementitious materials like concrete subjected to blast and/or high-velocity impact are problems of high complexity. In the current asymmetric war environment around the globe, there is significant interest to study the performance of concrete panels as armor material in resisting the ballistic impact of projectiles of different types and impact velocities. Extensive experimental solution to the problem is not realistic, because it can be very expensive and highly time consuming. To be able to predict the behavior corresponding to the myriads of possibilities, reliable numerical simulations by a discrete numerical method is the sensible alternative. Different material models have been used over the past two decades to realistically simulate the behavior of concrete under dynamic, highly localized, high-velocity impact conditions. The present study gives an overview of the mechanics of such effects, identify the most popular material models that have been tried recently to properly predict the behavior through finite element simulations, present an improved model for superior prediction of response, and validate the proposed model using example problems for which experimental results are generated by way of actual impact tests. (C) 2013 Published by Elsevier B.V. C1 [Nordendale, N. A.; Hickman, M. A.; Zhang, B.; Basu, P. K.] Vanderbilt Univ, Dept Civil Engn, Nashville, TN 37235 USA. [Heard, W. F.] US Army Corps Engineers, Erdc, Vicksburg, MS USA. RP Basu, PK (reprint author), Vanderbilt Univ, Dept Civil Engn, 2301 Vanderbilt Pl, Nashville, TN 37235 USA. EM p.k.basu@vandebilt.edu FU Engineering Research and Development Center of the U.S. Army Corps of Engineers FX This work was completed with the funding and support of the Engineering Research and Development Center of the U.S. Army Corps of Engineers. NR 20 TC 1 Z9 1 U1 0 U2 2 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0927-0256 J9 COMP MATER SCI JI Comput. Mater. Sci. PD NOV PY 2013 VL 79 BP 745 EP 758 DI 10.1016/j.commatsci.2013.06.039 PG 14 WC Materials Science, Multidisciplinary SC Materials Science GA 218ZE UT WOS:000324471100095 ER PT J AU Berkowitz, JF AF Berkowitz, Jacob F. TI Development of restoration trajectory metrics in reforested bottomland hardwood forests applying a rapid assessment approach SO ECOLOGICAL INDICATORS LA English DT Article DE Restoration trajectory; Wetland; Rapid assessment; Hydrogeomorphic (HGM) approach; Bottomland hardwood forest; Mississippi valley ID RIVER ALLUVIAL VALLEY; ECOLOGICAL RESTORATION; FUNCTIONAL ASSESSMENT; SUCCESSION; SYSTEM; MITIGATION; WETLANDS; LIGHT AB Large scale wetland restoration and reforestation efforts continue to expand throughout the Lower Mississippi Valley. Monitoring of restoration performance and the development of restoration trajectories pose challenges to resource managers and remain problematic due to (1) temporal patterns in forest succession, (2) budget constraints and short project monitoring timeframes, (3) disparity in the extent of pre-restoration hydrologic and landscape manipulations, and (4) lack of coherent restoration performance standards. The current work establishes a framework for identifying restoration trajectory metrics within project-relevant timescales. The study examined 17 variables commonly applied in rapid assessments. Four variables yielded positive restoration trajectories within a few years to 20 years. These include shrub-sapling density, ground vegetation cover, and development of organic and A soil horizons. Remaining variables including flood frequency and tree density provide limited useful information within critical early years following reforestation due to the time required for measurable changes to occur. As a result, assessment components are classified into three categories of rapid response, response, and stable variables. Restoring entities should maximize stable variables (e.g., afforestation species composition) during project implementation through site selection and planting techniques; while development of restoration milestones should focus on rapid response variables. Data collected at mature bottomland hardwood control sites displays the non-linearity of trajectory curves over decadal time scales. Published by Elsevier Ltd. C1 [Berkowitz, Jacob F.] US Army, Wetlands & Coastal Ecol Branch, Corps Engineers, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. [Berkowitz, Jacob F.] Louisiana State Univ, Wetland & Aquat Biogeochem Lab, Baton Rouge, LA 70803 USA. RP Berkowitz, JF (reprint author), US Army, Wetlands & Coastal Ecol Branch, Corps Engineers, Engineer Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM Jacob.F.Berkowitz@usace.army.mil NR 54 TC 5 Z9 6 U1 2 U2 54 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1470-160X J9 ECOL INDIC JI Ecol. Indic. PD NOV PY 2013 VL 34 BP 600 EP 606 DI 10.1016/j.ecolind.2013.06.025 PG 7 WC Biodiversity Conservation; Environmental Sciences SC Biodiversity & Conservation; Environmental Sciences & Ecology GA 210UR UT WOS:000323860700063 ER PT J AU Albert, DG Taherzadeh, S Attenborough, K Boulanger, P Decato, SN AF Albert, Donald G. Taherzadeh, Shahram Attenborough, Keith Boulanger, Patrice Decato, Stephen N. TI Ground vibrations produced by surface and near-surface explosions SO APPLIED ACOUSTICS LA English DT Article DE Acoustic-to-seismic coupling; Outdoor sound propagation; Ground vibration; Seismic wave propagation; Building damage criteria ID ACOUSTIC PROPAGATION; SOUND-PROPAGATION; FREQUENCY RANGE; AIRBORNE SOUND; ELASTIC WAVES; SHOCK-WAVES; SONIC-BOOMS; MODEL; FLUID; MEDIA AB Measurements of seismic signatures produced by airborne, near-surface detonations of explosive charges over a variety of ground types show two distinct ground vibration arrivals. In all cases, the earlier arrival (precursor), has a time of arrival consistent with a predominantly underground path and coupling of blast sound to the ground close to the source and is always much smaller than the later vibration, the time of arrival of which is consistent with coupling from the air blast arrival at the receiver. The ratio of the seismic particle velocity to the acoustic pressure at the surface for the air-coupled seismic wave is constant with respect to distance and maximum pressure at a given location, but varies from site to site, with values usually between 1 and 13 mu m s(-1) Pa-1. For the precursor seismic wave, a coupling coefficient of 0.16 mu m s(-1) Pa-1 was measured. A numerical code enabling calculations of the fields due to an impulsive source above a layered poroelastic ground is described. Predictions of the air pressure spectrum above ground and the vertical and radial components of solid particle velocity near the ground surface are found to compare tolerably well with the measured spectra and waveforms of acoustic and seismic pulses at about 100 m range in seismically-hard and -soft soils and with a snow cover present. The predicted seismic responses in 'soft' soil confirm that the existence of a near-surface S-wave speed less than that in air is responsible for the observed 'ringing', i.e. a long low-frequency wavetrain associated with coupling to the dispersive Rayleigh wave. The predicted seismic pulses in the presence of the shallow snow cover explain the observed phenomenon whereby a high frequency ground vibration is modulated by a lower frequency layer resonance. An empirical equation relating ground vibration from explosions to distance predicts that the commonly-used vibrational damage peak velocity criterion of 12 or 25 mm s(-1) will be exceeded when the peak positive pressure exceeds 480 Pa (147.6 dB) or 1 kPa (154.0 dB), respectively. Either of these levels is much higher than the current U.S. Army overpressure damage criterion of 159 Pa (138 dB). Thus in most situations damage from blast overpressure will occur long before damaging levels of ground vibration are reached, so it is likely that civilian perceptions of vibration are produced by coupling from the airblast. Published by Elsevier Ltd. C1 [Albert, Donald G.; Decato, Stephen N.] USA, Cold Reg Res & Engn Lab, Erdc, Hanover, NH 03755 USA. [Taherzadeh, Shahram; Attenborough, Keith] Open Univ, Fac Math Comp & Technol, Milton Keynes MK7 6AA, Bucks, England. [Boulanger, Patrice] Univ Hull, Dept Engn, Kingston Upon Hull HU6 7RX, N Humberside, England. RP Albert, DG (reprint author), USA, Cold Reg Res & Engn Lab, Erdc, 72 Lyme Rd, Hanover, NH 03755 USA. EM Donald.G.Albert@usace.army.mil FU SERDP SEED [SI-1410] FX The measurements analyzed in this report came from a variety of sources. We would like to thank Mr. Richard Andrejkovics and Mr. Andre Edwin, US Army PM-CCS (Project Manager, Close Combat Systems) for funding Tests 1, 2, 4, and 6 as part of the Sympathetic Detonator (SYDET) project, and the many individuals from various government agencies who assisted in the management and conduct of these tests. Mr. Gary Leadore and Ms. Martha Turnbaugh of the US Army Aberdeen Test Center coordinated these tests. The measurements reported for Tests 3 and 5 were funded by Dr. Larry Pater, Project Leader for Military Noise Management, US Army ERDC-CERL. The snow pistol shot data used to confirm the theoretical waveform model and analysis support was provided by the US Army Corps of Engineers AT24 basic research program. Additional analysis support was provided through SERDP SEED Project SI-1410. Dr. Robert Hoist served as the Sustainable Infrastructure Program Manager and Mr. Bradley Smith was the Executive Director. All of these contributions are gratefully acknowledged. We thank the editor and an anonymous reviewer for useful comments that have improved this paper. This paper is dedicated to the memory of Mr. Rich Andrejkovics. NR 57 TC 6 Z9 8 U1 1 U2 70 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0003-682X J9 APPL ACOUST JI Appl. Acoust. PD NOV PY 2013 VL 74 IS 11 BP 1279 EP 1296 DI 10.1016/j.apacoust.2013.03.006 PG 18 WC Acoustics SC Acoustics GA 186NK UT WOS:000322051100008 ER PT J AU Srikanth, A Hoy, RS Rinderspacher, BC Andzelm, JW AF Srikanth, Arvind Hoy, Robert S. Rinderspacher, Berend C. Andzelm, Jan W. TI Nonlinear mechanics of thermoreversibly associating dendrimer glasses SO PHYSICAL REVIEW E LA English DT Article ID SUPRAMOLECULAR POLYMER NETWORKS; HYDROGEN-BONDING INTERACTIONS; PI-PI STACKING; VISCOELASTIC PROPERTIES; MOLECULAR-DYNAMICS; MAIN-CHAIN; BEHAVIOR; MELTS; RHEOLOGY; GELATION AB We model the mechanics of associating trivalent dendrimer network glasses with a focus on their energy dissipation properties. Various combinations of sticky bond (SB) strength and kinetics are employed. The toughness (work to fracture) of these systems displays a surprising deformation-protocol dependence; different association parameters optimize different properties. In particular, "strong, slow"SBs optimize strength, while "weak, fast"SBs optimize ductility via self-healing during deformation. We relate these observations to breaking, reformation, and partner switching of SBs during deformation. These studies point theway to creating associatingpolymer network glasses with tailorable mechanical properties. C1 [Srikanth, Arvind; Hoy, Robert S.] Univ S Florida, Dept Phys, Tampa, FL 33620 USA. [Rinderspacher, Berend C.; Andzelm, Jan W.] US Army Res Lab, Weap & Mat Res Directorate, Aberdeen, MD 21005 USA. RP Srikanth, A (reprint author), Univ S Florida, Dept Phys, Tampa, FL 33620 USA. EM rshoy@usf.edu FU ARL [TCN-11042]; US ARL Enterprise for Multi-Scale Research of Materials; REU program at USF [DMR-1263066] FX All simulations were performed using an enhanced version of LAMMPS [49]. This work was partially funded by ARL Contract No. TCN-11042 and the US ARL Enterprise for Multi-Scale Research of Materials. A. S. was supported by the REU program at USF (NSF Grant No. DMR-1263066). We would like to thank Yelena R. Sliozberg and Robert H. Lambeth for helpful discussions. NR 49 TC 1 Z9 1 U1 1 U2 27 PU AMER PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 1539-3755 EI 1550-2376 J9 PHYS REV E JI Phys. Rev. E PD OCT 31 PY 2013 VL 88 IS 4 AR 042607 DI 10.1103/PhysRevE.88.042607 PG 8 WC Physics, Fluids & Plasmas; Physics, Mathematical SC Physics GA 244MG UT WOS:000326392300009 PM 24229206 ER PT J AU Schwenk, R Banania, G Epstein, J Kim, Y Peters, B Belmonte, M Ganeshan, H Huang, J Reyes, S Stryhn, A Ockenhouse, CF Buus, S Richie, TL Sedegah, M AF Schwenk, Robert Banania, Glenna Epstein, Judy Kim, Yohan Peters, Bjoern Belmonte, Maria Ganeshan, Harini Huang, Jun Reyes, Sharina Stryhn, Anette Ockenhouse, Christian F. Buus, Soren Richie, Thomas L. Sedegah, Martha TI Ex vivo tetramer staining and cell surface phenotyping for early activation markers CD38 and HLA-DR to enumerate and characterize malaria antigen-specific CD8(+) T-cells induced in human volunteers immunized with a Plasmodium falciparum adenovirus-vectored malaria vaccine expressing AMA1 SO MALARIA JOURNAL LA English DT Article DE Malaria; CD8+T cells; MHC-I tetramers; Activation markers ID SPOROZOITES; PROTECTION AB Background: Malaria is responsible for up to a 600,000 deaths per year; conveying an urgent need for the development of a malaria vaccine. Studies with whole sporozoite vaccines in mice and non-human primates have shown that sporozoite-induced CD8(+) T cells targeting liver stage antigens can mediate sterile protection. There is a need for a direct method to identify and phenotype malaria vaccine-induced CD8(+) T cells in humans. Methods: Fluorochrome-labelled tetramers consisting of appropriate MHC class I molecules in complex with predicted binding peptides derived from Plasmodium falciparum AMA-1 were used to label ex vivo AMA-1 epitope specific CD8(+) T cells from research subjects responding strongly to immunization with the NMRC-M3V-Ad-PfCA (adenovirus-vectored) malaria vaccine. The identification of these CD8(+) T cells on the basis of their expression of early activation markers was also investigated. Results: Analyses by flow cytometry demonstrated that two of the six tetramers tested: TLDEMRHFY: HLA-A*01:01 and NEVVVKEEY: HLA-B*18:01, labelled tetramer-specific CD8(+) T cells from two HLA-A*01: 01 volunteers and one HLA-B*18: 01 volunteer, respectively. By contrast, post-immune CD8(+) T cells from all six of the immunized volunteers exhibited enhanced expression of the CD38 and HLA-DRhi early activation markers. For the three volunteers with positive tetramer staining, the early activation phenotype positive cells included essentially all of the tetramer positive, malaria epitope-specific CD8(+) T cells suggesting that the early activation phenotype could identify all malaria vaccine-induced CD8(+) T cells without prior knowledge of their exact epitope specificity. Conclusions: The results demonstrated that class I tetramers can identify ex vivo malaria vaccine antigen-specific CD8(+) T cells and could therefore be used to determine their frequency, cell surface phenotype and transcription factor usage. The results also demonstrated that vaccine antigen-specific CD8(+) T cells could be identified by activation markers without prior knowledge of their antigen-specificity, using a subunit vaccine for proof-of-concept. Whether, whole parasite or adjuvanted protein vaccines will also induce {CD38 and HLA-DRhi}(+) CD8(+) T cell populations reflective of the antigen-specific response will the subject of future investigations. C1 [Schwenk, Robert; Ockenhouse, Christian F.] Walter Reed Army Inst Res, Malaria Vaccine Branch, Malaria Res Program, Silver Spring, MD USA. [Banania, Glenna; Epstein, Judy; Belmonte, Maria; Ganeshan, Harini; Huang, Jun; Reyes, Sharina; Richie, Thomas L.; Sedegah, Martha] Naval Med Res Ctr, Infect Dis Directorate, Malaria Dept, Silver Spring, MD 20910 USA. [Stryhn, Anette; Buus, Soren] Univ Copenhagen, Expt Immunol Lab, Copenhagen, Denmark. [Kim, Yohan; Peters, Bjoern] La Jolla Inst Allergy & Immunol, La Jolla, CA USA. RP Sedegah, M (reprint author), Naval Med Res Ctr, Infect Dis Directorate, Malaria Dept, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM Martha.Sedegah@med.navy.mil RI Buus, Soren/F-5446-2010 NR 16 TC 5 Z9 6 U1 0 U2 5 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1475-2875 J9 MALARIA J JI Malar. J. PD OCT 29 PY 2013 VL 12 AR 376 DI 10.1186/1475-2875-12-376 PG 9 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA 281LH UT WOS:000329102500002 PM 24168370 ER PT J AU Lao, YF Pitigala, PKDDP Perera, AGU Plis, E Krishna, SS Wijewarnasuriya, PS AF Lao, Yan-Feng Pitigala, P. K. D. D. P. Perera, A. G. Unil Plis, E. Krishna, S. S. Wijewarnasuriya, Priyalal S. TI Band offsets and carrier dynamics of type-II InAs/GaSb superlattice photodetectors studied by internal photoemission spectroscopy SO APPLIED PHYSICS LETTERS LA English DT Article ID INFRARED DETECTORS AB We use internal photoemission spectroscopy to determine the conduction band offset of a type-II InAs/GaSb superlattice (T2SL) pBp photodetector to be 0.004 (+/- 0.004) eV at 78 K, confirming its unipolar operation. It is also found that phonon-assisted hole transport through the B-region disables its two-color detection mode around 140 K. In addition, photoemission yield shows a reduction at about an energy of longitudinal-optical phonon above the threshold, confirming carrier-phonon scattering degradation on the photoresponse. These results may indicate a pathway for optimizing T2SL detectors in addition to current efforts in material growth, processing, substrate preparation, and device passivation. (c) 2013 AIP Publishing LLC. C1 [Lao, Yan-Feng; Pitigala, P. K. D. D. P.; Perera, A. G. Unil] Georgia State Univ, Dept Phys & Astron, Atlanta, GA 30303 USA. [Plis, E.; Krishna, S. S.] Univ New Mexico, Dept Elect & Comp Engn, Ctr High Technol Mat, Albuquerque, NM 87106 USA. [Wijewarnasuriya, Priyalal S.] US Army Res Lab, Adelphi, MD 20783 USA. RP Perera, AGU (reprint author), Georgia State Univ, Dept Phys & Astron, Atlanta, GA 30303 USA. EM uperera@gsu.edu OI Lao, Yanfeng/0000-0002-6301-9417; Pitigala, P K D Duleepa/0000-0003-4824-0188 FU U.S. Army Research Office [W911NF-12-2-0035]; U.S. National Science Foundation [ECCS-1232184] FX This work was supported in part by the U.S. Army Research Office under Grant No. W911NF-12-2-0035 monitored by Dr. William W. Clark, and in part by the U.S. National Science Foundation under Grant No. ECCS-1232184. NR 19 TC 8 Z9 8 U1 5 U2 29 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0003-6951 EI 1077-3118 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD OCT 28 PY 2013 VL 103 IS 18 AR 181110 DI 10.1063/1.4827881 PG 4 WC Physics, Applied SC Physics GA 263NT UT WOS:000327816000074 ER PT J AU Roberts, AT Mohanta, A Everitt, HO Leach, JH Van den Broeck, D Hosalli, AM Paskova, T Bedair, SM AF Roberts, A. T. Mohanta, A. Everitt, H. O. Leach, J. H. Van den Broeck, D. Hosalli, A. M. Paskova, T. Bedair, S. M. TI Spectroscopic investigation of coupling among asymmetric InGaN/GaN multiple quantum wells grown on non-polar a-plane GaN substrates SO APPLIED PHYSICS LETTERS LA English DT Article ID LIGHT-EMITTING-DIODES; EMISSION; NITRIDE; EXCITONS AB Low defect density asymmetric multiple quantum wells (MQWs) of InGaN/GaN grown on non-polar a-plane GaN substrates were investigated using time-integrated and time-resolved photoluminescence spectroscopy. Comparison of these spectra with the predicted emission energies reveals that these QWs may be spectrally resolved at low temperatures. However, a combination of thermal activation and resonant tunneling of carriers increasingly coupled the QWs, favoring emission from the lowest energy QWs with increasing temperature in a manner analogous to MQWs composed of other non-polar semiconductor materials but unlike most InGaN MQWs grown on polar substrates and influenced by the strong polarization-dependent effects. (C) 2013 AIP Publishing LLC. C1 [Roberts, A. T.; Everitt, H. O.] US Army, Aviat & Missile Res Dev & Engn Ctr, Redstone Arsenal, AL 35898 USA. [Mohanta, A.] US Army, Aviat & Missile Res Dev & Engn Ctr, Oak Ridge Inst Sci & Educ, Res Participat Program, Redstone Arsenal, AL 35898 USA. [Everitt, H. O.] Duke Univ, Dept Phys, Durham, NC 27708 USA. [Leach, J. H.] Kyma Technol, Raleigh, NC 27617 USA. [Van den Broeck, D.; Hosalli, A. M.; Paskova, T.; Bedair, S. M.] N Carolina State Univ, Dept Elect & Comp Engn, Raleigh, NC 27695 USA. RP Paskova, T (reprint author), N Carolina State Univ, Dept Elect & Comp Engn, Raleigh, NC 27695 USA. EM tmpaskov@ncsu.edu RI Everitt, Henry/L-7118-2013 OI Everitt, Henry/0000-0002-8141-3768 FU National Science Foundation [DMR-1105842, DMR-1207075] FX This research was supported in part by appointment of A.M. to the Postgraduate Research Participation Program at the U.S. Army Aviation and Missile Research, Development and Engineering Center administered by the Oak Ridge Institute for Science and Education through an interagency agreement with the U.S. Department of Energy, as well as by National Science Foundation (Nos. DMR-1105842 and DMR-1207075). NR 26 TC 2 Z9 2 U1 1 U2 29 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0003-6951 EI 1077-3118 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD OCT 28 PY 2013 VL 103 IS 18 AR 181106 DI 10.1063/1.4827536 PG 4 WC Physics, Applied SC Physics GA 263NT UT WOS:000327816000049 ER PT J AU Khavrutskii, IV Smith, JB Wallqvist, A AF Khavrutskii, Ilja V. Smith, Jason B. Wallqvist, Anders TI Exploring chemical reaction mechanisms through harmonic Fourier beads path optimization SO JOURNAL OF CHEMICAL PHYSICS LA English DT Article ID NUDGED ELASTIC BAND; MINIMUM-ENERGY PATHS; ENDED CLASSICAL TRAJECTORIES; LOCATING TRANSITION-STATES; GROWING STRING METHOD; AB-INITIO; EQUILIBRIUM GEOMETRIES; MOLECULAR-MECHANICS; CATALYTIC MECHANISM; REACTION COORDINATE AB Here, we apply the harmonic Fourier beads (HFB) path optimization method to study chemical reactions involving covalent bond breaking and forming on quantum mechanical (QM) and hybrid QM/molecular mechanical (QM/MM) potential energy surfaces. To improve efficiency of the path optimization on such computationally demanding potentials, we combined HFB with conjugate gradient (CG) optimization. The combined CG-HFB method was used to study two biologically relevant reactions, namely, L- to D-alanine amino acid inversion and alcohol acylation by amides. The optimized paths revealed several unexpected reaction steps in the gas phase. For example, on the B3LYP/6-31G(d,p) potential, we found that alanine inversion proceeded via previously unknown intermediates, 2-iminopropane-1,1-diol and 3-amino-3-methyloxiran-2-ol. The CG-HFB method accurately located transition states, aiding in the interpretation of complex reaction mechanisms. Thus, on the B3LYP/6-31G(d, p) potential, the gas phase activation barriers for the inversion and acylation reactions were 50.5 and 39.9 kcal/mol, respectively. These barriers determine the spontaneous loss of amino acid chirality and cleavage of peptide bonds in proteins. We conclude that the combined CG-HFB method further advances QM and QM/MM studies of reaction mechanisms. (C) 2013 Author(s). All article content, except where otherwise noted, is licensed under a Creative Commons Attribution 3.0 Unported License. C1 [Khavrutskii, Ilja V.; Smith, Jason B.; Wallqvist, Anders] US Army, Biotechnol High Performance Comp Software Applica, Telemed & Adv Technol Res Ctr, Med Res & Mat Command, Ft Detrick, MD 21702 USA. RP Khavrutskii, IV (reprint author), US Army, Biotechnol High Performance Comp Software Applica, Telemed & Adv Technol Res Ctr, Med Res & Mat Command, Ft Detrick, MD 21702 USA. EM ikhavrutskii@bhsai.org OI wallqvist, anders/0000-0002-9775-7469 FU U.S. Department of Defense High Performance Computing Modernization Program under the High Performance Computing Software Applications Institutes initiative; Defense Threat Reduction Agency [CBM.THERB.02.11.RD.012] FX This work was supported by the U.S. Department of Defense High Performance Computing Modernization Program under the High Performance Computing Software Applications Institutes initiative. Computational time was provided by the U.S. Army Research Laboratory Department of Defense Supercomputing Resource Center. This work was sponsored by the Defense Threat Reduction Agency Grant No. CBM.THERB.02.11.RD.012. The opinions and assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the U.S. Army or the U.S. Department of Defense. This paper has been approved for public release with unlimited distribution. NR 63 TC 2 Z9 2 U1 3 U2 12 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0021-9606 EI 1089-7690 J9 J CHEM PHYS JI J. Chem. Phys. PD OCT 28 PY 2013 VL 139 IS 16 AR 165104 DI 10.1063/1.4826470 PG 10 WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical SC Chemistry; Physics GA 247RP UT WOS:000326637500091 PM 24182085 ER PT J AU Cole, MW Ngo, E Hubbard, C Hirsch, SG Ivill, M Sarney, WL Zhang, J Alpay, SP AF Cole, M. W. Ngo, E. Hubbard, C. Hirsch, S. G. Ivill, M. Sarney, W. L. Zhang, J. Alpay, S. P. TI Enhanced dielectric properties from barium strontium titanate films with strontium titanate buffer layers SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID TUNABLE DEVICE APPLICATIONS; BA1-XSRXTIO3 THIN-FILMS; ELECTRICAL-PROPERTIES; TUNABILITY; CERAMICS; SRTIO3; MORPHOLOGY AB In order to enhance the permittivity and tunability of the dielectric component, a thin film dielectric composite consisting of a radio frequency sputtered SrTiO3 (STO) buffer layer and metalorganic solution deposited Mg-doped BaxSr1-xTiO3 (Mg-BST) thin film overgrowth was developed using affordable industry standard processes and materials. The effect of the STO buffer layer thickness on the dielectric response of the heterostructure was investigated. Our results demonstrate that the composite film heterostructure, evaluated in the metal-insulator-metal configuration Pt/STO/Mg-BST/Pt on sapphire substrate, with the thinner (9-17 nm) STO buffer layers possessed enhanced permittivity (epsilon(r) similar to 491) with respect to the thicker 41 nm buffer layer (epsilon(r) similar to 360) and that of a control Mg-BST film without a STO buffer layer (epsilon(r) similar to 380). Additionally, the composite film with the thinner buffer layers were shown to have low losses (tan delta similar to 0.02), low leakage characteristics (J = 7.0 x 10(-9) A/cm(2)), high breakdown voltage (V-BR > 10 V), a large grain microstructure (similar to 125 nm), and smooth pin-hole free surfaces. The enhanced permittivity of the composite dielectric film resulted from three major factors: (i) the template-effect of the thin STO buffer layer on the thicker Mg-BST over-layer film to achieve a large grain microstructure, (ii) the low viscosity of the metallo-organic solution deposition (MOSD) solution, which ensured heterogeneous nucleation of the Mg-BST overgrowth film on the surface of the STO buffer layer, and (iii) minimization of the low permittivity grain boundary phase (TiO2-x phase). The dielectric response of the BST can be explained using a thermodynamic model taking into account interlayer electrostatic and electromechanical interactions. Additionally, Mg doping of the BST enabled low loss and low leakage characteristics of the heterostructure. The large permittivity, low loss, low leakage characteristics, and defect free surfaces of the composite dielectric heterostructure promote tunable device miniaturization and hold the potential to enable enhanced electromagnetic coupling in ferromagnetic/high permittivity dielectric heterostructures, which in turn would facilitate the realization of integrated charge mediated voltage controlled magnetic radio frequency/microwave communication devices. (C) 2013 AIP Publishing LLC. C1 [Cole, M. W.; Ngo, E.; Hubbard, C.; Hirsch, S. G.; Ivill, M.] US Army Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. [Sarney, W. L.] US Army Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA. [Zhang, J.; Alpay, S. P.] Univ Connecticut, Dept Mat Sci & Engn, Storrs, CT 06269 USA. [Zhang, J.; Alpay, S. P.] Univ Connecticut, Inst Mat Sci, Storrs, CT 06269 USA. RP Cole, MW (reprint author), US Army Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. EM melanie.w.cole.civ@mail.mil RI Alpay, Pamir/E-2666-2013 NR 46 TC 18 Z9 19 U1 4 U2 57 PU AMER INST PHYSICS PI MELVILLE PA 1305 WALT WHITMAN RD, STE 300, MELVILLE, NY 11747-4501 USA SN 0021-8979 EI 1089-7550 J9 J APPL PHYS JI J. Appl. Phys. PD OCT 28 PY 2013 VL 114 IS 16 AR 164107 DI 10.1063/1.4827421 PG 10 WC Physics, Applied SC Physics GA 247SE UT WOS:000326639200077 ER PT J AU Smith, JR AF Smith, Joshua Ryan TI Increasing the efficiency of a thermionic engine using a negative electron affinity collector SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID SPACE-CHARGE; ENERGY CONVERTER; EMISSION; SURFACE AB Most attention to improving vacuum thermionic energy conversion device (TEC) technology has been on improving electron emission with little attention to collector optimization. A model was developed to characterize the output characteristics of a TEC where the collector features negative electron affinity. According to the model, there are certain conditions for which the space charge limitation can be reduced or eliminated. The model is applied to devices comprised materials reported in the literature, and predictions of output power and efficiency are made, targeting the sub-1000K hot-side regime. By slightly lowering the collector barrier height, an output power of around 1 kW, at >= 20% efficiency for a reasonably sized device (similar to 0.1 m(2) emission area) can be achieved. (C) 2013 Author(s). C1 US Army Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA. RP Smith, JR (reprint author), US Army Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA. EM joshua.smith133.ctr@mail.mil OI Smith, Joshua/0000-0002-3137-7180 FU Army Research Laboratory; [W911NF-12-2-0019] FX Research was sponsored by the Army Research Laboratory and was accomplished under Cooperative Agreement Number W911NF-12-2-0019. The views and conclusions contained in this document are those of the authors and should not be interpreted as representing the official policies, either expressed or implied, of the Army Research Laboratory or the U.S. Government. The U.S. Government is authorized to reproduce and distribute reprints for Government purposes notwithstanding any copyright notation herein. NR 20 TC 4 Z9 4 U1 1 U2 16 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0021-8979 EI 1089-7550 J9 J APPL PHYS JI J. Appl. Phys. PD OCT 28 PY 2013 VL 114 IS 16 AR 164514 DI 10.1063/1.4826202 PG 7 WC Physics, Applied SC Physics GA 247SE UT WOS:000326639200114 ER PT J AU Brown, RS Deng, ZD Cook, KV Pflugrath, BD Li, XY Fu, T Martinez, JJ Li, HD Trumbo, BA Ahmann, ML Seaburg, AG AF Brown, Richard S. Deng, Z. Daniel Cook, Katrina V. Pflugrath, Brett D. Li, Xinya Fu, Tao Martinez, Jayson J. Li, Huidong Trumbo, Bradly A. Ahmann, Martin L. Seaburg, Adam G. TI A Field Evaluation of an External and Neutrally Buoyant Acoustic Transmitter for Juvenile Salmon: Implications for Estimating Hydroturbine Passage Survival SO PLOS ONE LA English DT Article ID HYDRO-TURBINE PASSAGE; CHINOOK SALMON; SWIMMING PERFORMANCE; SNAKE RIVER; COLUMBIA RIVER; TELEMETRY TRANSMITTERS; ATTACHED TRANSMITTERS; ANADROMOUS SALMONIDS; AVIAN PREDATION; SMALLMOUTH BASS AB Turbine-passed fish are exposed to rapid decreases in pressure which can cause barotrauma. The presence of an implanted telemetry tag increases the likelihood of injury or death from exposure to pressure changes, thus potentially biasing studies evaluating survival of turbine-passed fish. Therefore, a neutrally buoyant externally attached tag was developed to eliminate this bias in turbine passage studies. This new tag was designed not to add excess mass in water or take up space in the coelom, having an effective tag burden of zero with the goal of reducing pressure related biases to turbine survival studies. To determine if this new tag affects fish performance or susceptibility to predation, it was evaluated in the field relative to internally implanted acoustic transmitters (JSATS; Juvenile Salmon Acoustic Telemetry System) used widely for survival studies of juvenile salmonids. Survival and travel time through the study reach was compared between fish with either tag type in an area of high predation in the Snake and Columbia rivers, Washington. An additional group of fish affixed with neutrally-buoyant dummy external tags were implanted with passive integrated transponder (PIT) tags and recovered further downstream to assess external tag retention and injury. There were no significant differences in survival to the first detection site, 12 river kilometers (rkm) downstream of release. Travel times were also similar between groups. Conversely, externally-tagged fish had reduced survival (or elevated tag loss) to the second detection site, 65 rkm downstream. In addition, the retention study revealed that tag loss was first observed in fish recaptured approximately 9 days after release. Results suggest that this new tag may be viable for short term (< 8 days) single-dam turbine-passage studies and under these situations, may alleviate the turbine passage-related bias encountered when using internal tags, however further research is needed to confirm this. C1 [Brown, Richard S.; Cook, Katrina V.; Pflugrath, Brett D.] Pacific NW Natl Lab, Ecol Grp, Richland, WA 99352 USA. [Deng, Z. Daniel; Li, Xinya; Fu, Tao; Martinez, Jayson J.; Li, Huidong] Pacific NW Natl Lab, Hydrol Grp, Richland, WA 99352 USA. [Trumbo, Bradly A.; Ahmann, Martin L.] US Army, Corps Engineers, Walla Walla, WA USA. [Seaburg, Adam G.] Univ Washington, Sch Aquat & Fishery Sci, Seattle, WA 98195 USA. RP Brown, RS (reprint author), Pacific NW Natl Lab, Ecol Grp, Richland, WA 99352 USA. EM rich.brown@pnnl.gov RI Deng, Daniel/A-9536-2011 OI Deng, Daniel/0000-0002-8300-8766 FU U.S. Army corps of Engineers, Walla Walla district (Walla Walla Washington State) [W912EF-08-D-0004] FX This study was funded by the U.S. Army corps of Engineers, Walla Walla district (Walla Walla Washington State) under contract number W912EF-08-D-0004. Funders were involved in study design and preparation of the manuscript (authors BAT and MLA). NR 55 TC 2 Z9 2 U1 3 U2 25 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD OCT 25 PY 2013 VL 8 IS 10 AR e77744 DI 10.1371/journal.pone.0077744 PG 11 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 241GW UT WOS:000326155400054 PM 24204947 ER PT J AU Padte, NN Boente-Carrera, M Andrews, CD McManus, J Grasperge, BF Gettie, A Coelho-dos-Reis, JG Li, XM Wu, D Bruder, JT Sedegah, M Patterson, N Richie, TL Wong, CH Ho, DD Vasan, S Tsuji, M AF Padte, Neal N. Boente-Carrera, Mar Andrews, Chasity D. McManus, Jenny Grasperge, Brooke F. Gettie, Agegnehu Coelho-dos-Reis, Jordana G. Li, Xiangming Wu, Douglass Bruder, Joseph T. Sedegah, Martha Patterson, Noelle Richie, Thomas L. Wong, Chi-Huey Ho, David D. Vasan, Sandhya Tsuji, Moriya TI A Glycolipid Adjuvant, 7DW8-5, Enhances CD8+T Cell Responses Induced by an Adenovirus-Vectored Malaria Vaccine in Non-Human Primates SO PLOS ONE LA English DT Article ID KILLER T-CELLS; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; PHASE I/II TRIAL; ALPHA-GALACTOSYLCERAMIDE; DENDRITIC CELLS; NKT CELLS; IN-VIVO; CIRCUMSPOROZOITE PROTEIN; PROTECTIVE IMMUNITY; PERIPHERAL-BLOOD AB A key strategy to a successful vaccine against malaria is to identify and develop new adjuvants that can enhance T-cell responses and improve protective immunity. Upon co-administration with a rodent malaria vaccine in mice, 7DW8-5, a recently identified novel analog of alpha-galactosylceramide (alpha-GalCer), enhances the level of malaria-specific protective immune responses more strongly than the parent compound. In this study, we sought to determine whether 7DW8-5 could provide a similar potent adjuvant effect on a candidate human malaria vaccine in the more relevant non-human primate (NHP) model, prior to committing to clinical development. The candidate human malaria vaccine, AdPfCA (NMRC-M3V-Ad-PfCA), consists of two non-replicating recombinant adenoviral (Ad) vectors, one expressing the circumsporozoite protein (CSP) and another expressing the apical membrane antigen-1 (AMA1) of Plasmodium falciparum. In several phase 1 clinical trials, AdPfCA was well tolerated and demonstrated immunogenicity for both humoral and cell-mediated responses. In the study described herein, 25 rhesus macaques received prime and boost intramuscular (IM) immunizations of AdPfCA alone or with an ascending dose of 7DW8-5. Our results indicate that 7DW8-5 is safe and well-tolerated and provides a significant enhancement (up to 9-fold) in malaria-specific CD8+ T-cell responses after both priming and boosting phases, supporting further clinical development. C1 [Padte, Neal N.; Boente-Carrera, Mar; Andrews, Chasity D.; McManus, Jenny; Coelho-dos-Reis, Jordana G.; Li, Xiangming; Ho, David D.; Vasan, Sandhya; Tsuji, Moriya] Rockefeller Univ, Aaron Diamond AIDS Res Ctr, New York, NY 10021 USA. [Grasperge, Brooke F.; Gettie, Agegnehu] Tulane Univ, Med Ctr, Tulane Natl Primate Res Ctr, Covington, LA USA. [Wu, Douglass; Wong, Chi-Huey] Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA. [Bruder, Joseph T.] GenVec Inc, Res, Gaithersburg, MD USA. [Sedegah, Martha; Patterson, Noelle; Richie, Thomas L.] Naval Med Res Ctr, US Mil Malaria Vaccine Program, Silver Spring, MD USA. [Patterson, Noelle] Henry M Jackson Fdn Adv Mil Med, Bethesda, MD USA. RP Vasan, S (reprint author), Henry M Jackson Fdn, Armed Forces Res Inst Med Sci, US Mil HIV Res Program, Bangkok, Thailand. EM sandhya.vasan@afrims.org; mtsuji@adarc.org OI Richie, Thomas/0000-0002-2946-5456; Tsuji, Moriya/0000-0001-8587-277X FU NIH [AI070258]; Bill and Melinda Gates Foundation Collaboration for AIDS Vaccine Discovery [38648]; Irene Diamond Foundation FX This work was partially supported by a grant from NIH AI070258 (M. T.), the Bill and Melinda Gates Foundation Collaboration for AIDS Vaccine Discovery (Grant Number 38648 to D. D. H), and the Irene Diamond Foundation. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 57 TC 13 Z9 13 U1 2 U2 21 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD OCT 25 PY 2013 VL 8 IS 10 AR e78407 DI 10.1371/journal.pone.0078407 PG 11 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 241GW UT WOS:000326155400081 PM 24205224 ER PT J AU Sakamoto, J Rangasamy, E Kim, H Kim, Y Wolfenstine, J AF Sakamoto, Jeff Rangasamy, Ezhiylmurugan Kim, Hyunjoung Kim, Yunsung Wolfenstine, Jeff TI Synthesis of nano-scale fast ion conducting cubic Li7La3Zr2O12 SO NANOTECHNOLOGY LA English DT Article ID GRAIN-BOUNDARY CONDUCTIVITY; LITHIUM LANTHANUM TITANATES; 316L STAINLESS-STEEL; ZIRCONIA; NANOCRYSTALLINE; ELECTROLYTE; TRANSITION; CHEMISTRY; CERAMICS; BATTERY AB A solution-based process was investigated for synthesizing cubic Li7La3Zr2O12 (LLZO), which is known to exhibit the unprecedented combination of fast ionic conductivity, and stability in air and against Li. Sol-gel chemistry was developed to prepare solid metal-oxide networks consisting of 10 nm cross-links that formed the cubic LLZO phase at 600 degrees C. Sol-gel LLZO powders were sintered into 96% dense pellets using an induction hot press that applied pressure while heating. After sintering, the average LLZO grain size was 260 nm, which is 13 times smaller compared to LLZO prepared using a solid-state technique. The total ionic conductivity was 0:4 mS cm(-1) at 298 K, which is the same as solid-state synthesized LLZO. Interestingly, despite the same room temperature conductivity, the sol-gel LLZO total activation energy is 0.41 eV, which 1.6 times higher than that observed in solid-state LLZO (0.26 eV). We believe the nano-scale grain boundaries give rise to unique transport phenomena that are more sensitive to temperature when compared to the conventional solid-state LLZO. C1 [Sakamoto, Jeff; Rangasamy, Ezhiylmurugan; Kim, Hyunjoung; Kim, Yunsung] Michigan State Univ, Dept Chem Engn & Mat Sci, E Lansing, MI 48824 USA. [Wolfenstine, Jeff] RDRL SED C, Army Res Lab, Adelphi, MD 20783 USA. RP Sakamoto, J (reprint author), Michigan State Univ, Dept Chem Engn & Mat Sci, E Lansing, MI 48824 USA. EM jsakamot@msu.edu FU US Army Research Office [W911NF0910451] FX JS, EL, HK, and YK would like to acknowledge the support of the US Army Research Office under contract/grant number. W911NF0910451. NR 37 TC 20 Z9 20 U1 21 U2 161 PU IOP PUBLISHING LTD PI BRISTOL PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND SN 0957-4484 J9 NANOTECHNOLOGY JI Nanotechnology PD OCT 25 PY 2013 VL 24 IS 42 SI SI AR 424005 DI 10.1088/0957-4484/24/42/424005 PG 8 WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied SC Science & Technology - Other Topics; Materials Science; Physics GA 227VE UT WOS:000325142600007 PM 24067448 ER PT J AU Barouch, DH Stephenson, KE Borducchi, EN Smith, K Stanley, K McNally, AG Liu, JY Abbink, P Maxfield, LF Seaman, MS Dugast, AS Alter, G Ferguson, M Li, WJ Earl, PL Moss, B Giorgi, EE Szinger, JJ Eller, LA Billings, EA Rao, M Tovanabutra, S Sanders-Buell, E Weijtens, M Pau, MG Schuitemaker, H Robb, ML Kim, JH Korber, BT Michael, NL AF Barouch, Dan H. Stephenson, Kathryn E. Borducchi, Erica N. Smith, Kaitlin Stanley, Kelly McNally, Anna G. Liu, Jinyan Abbink, Peter Maxfield, Lori F. Seaman, Michael S. Dugast, Anne-Sophie Alter, Galit Ferguson, Melissa Li, Wenjun Earl, Patricia L. Moss, Bernard Giorgi, Elena E. Szinger, James J. Eller, Leigh Anne Billings, Erik A. Rao, Mangala Tovanabutra, Sodsai Sanders-Buell, Eric Weijtens, Mo Pau, Maria G. Schuitemaker, Hanneke Robb, Merlin L. Kim, Jerome H. Korber, Bette T. Michael, Nelson L. TI Protective Efficacy of a Global HIV-1 Mosaic Vaccine against Heterologous SHIV Challenges in Rhesus Monkeys SO CELL LA English DT Article ID SIMIAN IMMUNODEFICIENCY VIRUS; T-LYMPHOCYTE RESPONSES; NEUTRALIZING ANTIBODIES; IMMUNE CONTROL; REPLICATION; DIVERSITY; MACAQUES; BREADTH; AIDS; IMMUNOGENICITY AB The global diversity of HIV-1 represents a critical challenge facing HIV-1 vaccine development. HIV-1 mosaic antigens are bioinformatically optimized immunogens designed for improved coverage of HIV-1 diversity. However, the protective efficacy of such global HIV-1 vaccine antigens has not previously been evaluated. Here, we demonstrate the capacity of bivalent HIV-1 mosaic antigens to protect rhesus monkeys against acquisition of infection following heterologous challenges with the difficult-to-neutralize simian-human immunodeficiency virus SHIV-SF162P3. Adenovirus/poxvirus and adenovirus/adenovirus vector-based vaccines expressing HIV-1 mosaic Env, Gag, and Pol afforded a significant reduction in the per-exposure acquisition risk following repetitive, intrarectal SHIV-SF162P3 challenges. Protection against acquisition of infection correlated with vaccine-elicited binding, neutralizing, and functional nonneutralizing antibodies, suggesting that the coordinated activity of multiple antibody functions may contribute to protection against difficult-to-neutralize viruses. These data demonstrate the protective efficacy of HIV-1 mosaic antigens and suggest a potential strategy for the development of a global HIV-1 vaccine. C1 [Barouch, Dan H.; Stephenson, Kathryn E.; Borducchi, Erica N.; Smith, Kaitlin; Stanley, Kelly; McNally, Anna G.; Liu, Jinyan; Abbink, Peter; Maxfield, Lori F.; Seaman, Michael S.] Harvard Univ, Beth Israel Deaconess Med Ctr, Sch Med, Ctr Virol & Vaccine Res, Boston, MA 02215 USA. [Barouch, Dan H.; Dugast, Anne-Sophie; Alter, Galit] Ragon Inst MGH Massachusetts Inst Technol & Harva, Boston, MA 02114 USA. [Ferguson, Melissa] Alpha Genesis Inc, Yemassee, SC 29945 USA. [Li, Wenjun] Univ Massachusetts, Sch Med, Worcester, MA 01605 USA. [Earl, Patricia L.; Moss, Bernard] NIAID, Bethesda, MD 20892 USA. [Giorgi, Elena E.; Szinger, James J.; Korber, Bette T.] Los Alamos Natl Lab, Los Alamos, NM 87545 USA. [Eller, Leigh Anne; Billings, Erik A.; Rao, Mangala; Tovanabutra, Sodsai; Sanders-Buell, Eric; Robb, Merlin L.; Kim, Jerome H.; Michael, Nelson L.] Walter Reed Army Inst Res, US Mil HIV Res Program, Rockville, MD 20850 USA. [Weijtens, Mo; Pau, Maria G.; Schuitemaker, Hanneke] Crucell Holland BV, NL-2301 CA Leiden, Netherlands. RP Barouch, DH (reprint author), Harvard Univ, Beth Israel Deaconess Med Ctr, Sch Med, Ctr Virol & Vaccine Res, Boston, MA 02215 USA. EM dbarouch@bidmc.harvard.edu RI Li, Wenjun/F-5634-2015; Dugast, AnneSophie/L-9541-2015 OI Li, Wenjun/0000-0001-5335-7386; FU U.S. Military Research and Material Command; U.S. Military HIV Research Program [W81XWH-07-2-0067]; National Institutes of Health [AI052074, AI060354, AI078526, AI084794, AI095985, AI096040, AI100645]; NIAID Division of Intramural Research; Ragon Institute of MGH, MIT, and Harvard; Bill and Melinda Gates Foundation [OPP1033091, OPP1040741] FX We thank M. Pensiero, S. Blackmore, R. Bradsky, C. Cabral, A. Cheung, J. Goudsmit, R. Hamel, B. Hibl, S. Howell, M. Iampietro, K. Kelly, D. Lynch, M. Marovich, C. Miller, J. Nkolola, A. O'Sullivan, L. Parenteau, J. Perry, W. Rinaldi, J. Sadoff, A. SanMiguel, N. Simmons, J. Smith, F. Stephens, D. van Manen, G. Westergaard, and L. Wyatt for generous advice, assistance, and reagents. The HIV-1 PTE peptides were obtained from the NIH AIDS Research and Reference Reagent Program. We acknowledge support from the U.S. Military Research and Material Command and the U.S. Military HIV Research Program (W81XWH-07-2-0067); the National Institutes of Health (AI052074, AI060354, AI078526, AI084794, AI095985, AI096040, and AI100645); the NIAID Division of Intramural Research; the Ragon Institute of MGH, MIT, and Harvard; and the Bill and Melinda Gates Foundation (OPP1033091 and OPP1040741). M. W., M. G. P., and H. S. are employees of Crucell. Beth Israel Deaconess Medical Center and Los Alamos National Laboratory are co-owners of an HIV-1 mosaic antigen patent that has been licensed to Crucell. The opinions in this manuscript are those of the authors and do not reflect the views of the U.S. Department of the Army or the Department of Defense. NR 37 TC 102 Z9 102 U1 1 U2 12 PU CELL PRESS PI CAMBRIDGE PA 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA SN 0092-8674 EI 1097-4172 J9 CELL JI Cell PD OCT 24 PY 2013 VL 155 IS 3 BP 531 EP 539 DI 10.1016/j.cell.2013.09.061 PG 9 WC Biochemistry & Molecular Biology; Cell Biology SC Biochemistry & Molecular Biology; Cell Biology GA 246WQ UT WOS:000326571800009 PM 24243013 ER PT J AU Cole, MW AF Cole, Melanie W. TI APPLIED PHYSICS Materials scientists take control SO NATURE LA English DT Editorial Material C1 US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Cole, MW (reprint author), US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA. EM melanie.w.cole.civ@mail.mil NR 5 TC 4 Z9 4 U1 1 U2 28 PU NATURE PUBLISHING GROUP PI LONDON PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND SN 0028-0836 EI 1476-4687 J9 NATURE JI Nature PD OCT 24 PY 2013 VL 502 IS 7472 BP 455 EP 457 PG 3 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 238YN UT WOS:000325988400035 PM 24132239 ER PT J AU Westervelt, JD Sperry, JH Burton, JL Palis, JG AF Westervelt, James D. Sperry, Jinelle H. Burton, Jennifer L. Palis, John G. TI Modeling response of frosted flatwoods salamander populations to historic and predicted climate variables SO ECOLOGICAL MODELLING LA English DT Article DE Ambystoma cingulatum; Hydrology; Climate change; Agent-based modeling ID GLOBAL AMPHIBIAN DECLINES; AMBYSTOMA-OPACUM; BREEDING SALAMANDERS; MARBLED SALAMANDER; LARVAL AMBYSTOMA; POND; CINGULATUM; EXTINCTIONS; MACULATUM; SURVIVAL AB For many amphibian species, particularly those that rely on ephemeral ponds for reproduction, population persistence can be dependent on landscape hydrology with years of suboptimal rainfall resulting in reproductive failure. Therefore, in order to accurately predict population persistence under future climate scenarios, it is necessary to incorporate pond hydrology. The frosted flatwoods salamander (Ambystoma cingulatum), a federally threatened species, has experienced dramatic population declines at Fort Stewart, Georgia. Here we used spatially explicit agent-based modeling to quantify the effects of historic climate data, with an emphasis on associated ephemeral pond depth and water retention, on salamander egg and larval survival. We then use these models to make predictions about climate thresholds for population persistence. Our models indicated wide fluctuations in Fort Stewart salamander populations from 1960 to 2010. Similar to what was documented with field collected survey data, our models showed a sharp decrease in populations during a drought in the late 1990s. Even modest reductions in annual rainfall (5-10%) would result in further population declines and more moderate reductions (20-25%) would result in population extirpation. Although climate change models predict relatively minor increases in temperature and precipitation in the Fort Stewart area, our models demonstrate the sensitivity of this salamander population to climate fluctuations and provide climate thresholds, below which, this population would likely not be able to recover. Published by Elsevier B.V. C1 [Westervelt, James D.; Sperry, Jinelle H.; Burton, Jennifer L.] Engineer Res & Dev Ctr, Champaign, IL 61826 USA. [Palis, John G.] Palis Environm Consulting, Jonesboro, IL 62952 USA. RP Sperry, JH (reprint author), Engineer Res & Dev Ctr, POB 4005, Champaign, IL 61826 USA. EM jinelle.sperry@usace.army.mil FU Engineer Research and Development Center FX This work was possible only with maps, data, and detailed knowledge of the area provided by Larry Carlile, John Macey, and Ron Owens. We thank Carola Haas and Thomas Gorman for sharing unpublished data derived from their ongoing drift fence studies of flatwoods salamanders. This work was funded through research funded by Jeff Holland, Director of the Engineer Research and Development Center and managed by Todd Bridges at the Center's Environmental Lab. We appreciate helpful comments on the manuscript from two anonymous reviewers. NR 43 TC 5 Z9 5 U1 4 U2 42 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0304-3800 EI 1872-7026 J9 ECOL MODEL JI Ecol. Model. PD OCT 24 PY 2013 VL 268 BP 18 EP 24 DI 10.1016/j.ecolmodel.2013.07.026 PG 7 WC Ecology SC Environmental Sciences & Ecology GA 234UH UT WOS:000325669300003 ER PT J AU Rochford, R Ohrt, C Baresel, PC Campo, B Sampath, A Magill, AJ Tekwani, BL Walker, LA AF Rochford, Rosemary Ohrt, Colin Baresel, Paul C. Campo, Brice Sampath, Aruna Magill, Alan J. Tekwani, Babu L. Walker, Larry A. TI Humanized mouse model of glucose 6-phosphate dehydrogenase deficiency for in vivo assessment of hemolytic toxicity SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA LA English DT Article ID RED-BLOOD-CELLS; PLASMODIUM-FALCIPARUM; SCID MICE; IMMUNOCOMPROMISED MICE; IMMUNODEFICIENT MICE; HUMAN ERYTHROCYTES; HUMAN MALARIA; PRIMAQUINE; DRUG; TRANSMISSION AB Individuals with glucose 6-phosphate dehydrogenase (G6PD) deficiency are at risk for the development of hemolytic anemia when given 8-aminoquinolines (8-AQs), an important class of antimalarial/antiinfective therapeutics. However, there is no suitable animal model that can predict the clinical hemolytic potential of drugs. We developed and validated a human (hu)RBC-SCID mouse model by giving nonobese diabetic/SCID mice daily transfusions of huRBCs from G6PD-deficient donors. Treatment of SCID mice engrafted with G6PD-deficient huRBCs with primaquine, an 8-AQ, resulted in a dose-dependent selective loss of huRBCs. To validate the specificity of this model, we tested known nonhemolytic antimalarial drugs: mefloquine, chloroquine, doxycycline, and pyrimethamine. No significant loss of G6PD-deficient huRBCs was observed. Treatment with drugs known to cause hemolytic toxicity (pamaquine, sitamaquine, tafenoquine, and dapsone) resulted in loss of G6PD-deficient huRBCs comparable to primaquine. This mouse model provides an important tool to test drugs for their potential to cause hemolytic toxicity in G6PD-deficient populations. C1 [Rochford, Rosemary; Baresel, Paul C.] SUNY Upstate Med Univ, Dept Microbiol & Immunol, Syracuse, NY 13210 USA. [Ohrt, Colin; Sampath, Aruna; Magill, Alan J.] Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD 20910 USA. [Campo, Brice] Med Malaria Venture, CH-1215 Geneva, Switzerland. [Tekwani, Babu L.; Walker, Larry A.] Univ Mississippi, Sch Pharm, Natl Ctr Nat Prod Res, University, MS 38677 USA. [Tekwani, Babu L.; Walker, Larry A.] Univ Mississippi, Sch Pharm, Dept Pharmacol, University, MS 38677 USA. RP Rochford, R (reprint author), SUNY Upstate Med Univ, Dept Microbiol & Immunol, Syracuse, NY 13210 USA. EM rochforr@upstate.edu FU US Army Medical Research and Materiel Command [W81XWH-07-2-0095, WX81XWH-10-2-0059]; Medicines for Malaria Venture FX We thank Caroline Othoro, Marino Mauro, Julie Ritchie, and Nancy Fiore for excellent technical assistance; and Jeff Friedman (The Scripps Research Institute) for genotyping the G6PD-deficient donors. This work was supported by grants from the US Army Medical Research and Materiel Command, via Awards W81XWH-07-2-0095 and WX81XWH-10-2-0059 to the University of Mississippi (to L.A.W.). Funding was also provided by the Medicines for Malaria Venture (to R.R.). NR 39 TC 16 Z9 16 U1 0 U2 7 PU NATL ACAD SCIENCES PI WASHINGTON PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA SN 0027-8424 J9 P NATL ACAD SCI USA JI Proc. Natl. Acad. Sci. U. S. A. PD OCT 22 PY 2013 VL 110 IS 43 BP 17486 EP 17491 DI 10.1073/pnas.1310402110 PG 6 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 238JU UT WOS:000325943300070 PM 24101478 ER PT J AU Hartley, DJ Pedicini, EE Janssens, RVF Riedinger, LL Riley, MA Wang, X Miller, S Ayangeakaa, AD Carpenter, MP Carroll, JJ Cavey, J Chiara, CJ Chowdhury, P Garg, U Hota, SS Jackson, EG Kondev, FG Lauritsen, T Litz, M Ma, WC Matta, J Paul, ES Simpson, J Vanhoy, JR Zhu, S AF Hartley, D. J. Pedicini, E. E. Janssens, R. V. F. Riedinger, L. L. Riley, M. A. Wang, X. Miller, S. Ayangeakaa, A. D. Carpenter, M. P. Carroll, J. J. Cavey, J. Chiara, C. J. Chowdhury, P. Garg, U. Hota, S. S. Jackson, E. G. Kondev, F. G. Lauritsen, T. Litz, M. Ma, W. C. Matta, J. Paul, E. S. Simpson, J. Vanhoy, J. R. Zhu, S. TI Possible deformation evolution in the pi i(13/2) structure of Re-171 SO PHYSICAL REVIEW C LA English DT Article ID NUCLEAR-DATA SHEETS; COINCIDENCE DATA; WOBBLING MODE; CONFIGURATION; EXCITATIONS; LU-167; PHONON; BAND AB The phenomenon of wobbling can only occur for a nuclear shape with stable triaxial deformation. To date, only a few examples of this exotic collective mode have been observed in lutetium and tantalum isotopes. A search for a wobbling sequence was performed in Re-171 to determine if this feature can be observed in Z > 73 nuclei. No evidence was found for wobbling; however, an interaction between the pi i(13/2) sequence and another positive-parity band may give an indication on why wobbling may not occur in this nucleus. The level scheme for Re-171 was significantly extended and interpretations for the decay sequences are proposed within the context of the cranked shell model. C1 [Hartley, D. J.; Pedicini, E. E.; Cavey, J.; Vanhoy, J. R.] US Naval Acad, Dept Phys, Annapolis, MD 21402 USA. [Janssens, R. V. F.; Carpenter, M. P.; Chiara, C. J.; Lauritsen, T.; Zhu, S.] Argonne Natl Lab, Div Phys, Argonne, IL 60439 USA. [Riedinger, L. L.] Univ Tennessee, Dept Phys & Astron, Knoxville, TN 37996 USA. [Riley, M. A.; Wang, X.; Miller, S.] Florida State Univ, Dept Phys, Tallahassee, FL 32306 USA. [Ayangeakaa, A. D.; Garg, U.; Matta, J.] Univ Notre Dame, Dept Phys, Notre Dame, IN 46556 USA. [Carroll, J. J.; Litz, M.] Army Res Lab, Adelphi, MD 20783 USA. [Chiara, C. J.] Univ Maryland, Dept Chem & Biochem, College Pk, MD 20742 USA. [Chiara, C. J.; Kondev, F. G.] Argonne Natl Lab, Nucl Engn Div, Argonne, IL 60439 USA. [Chowdhury, P.; Hota, S. S.; Jackson, E. G.] Univ Massachusetts, Dept Phys, Lowell, MA 01854 USA. [Ma, W. C.] Mississippi State Univ, Dept Phys, Mississippi State, MS 39762 USA. [Paul, E. S.] Univ Liverpool, Oliver Lodge Lab, Liverpool L69 7ZE, Merseyside, England. [Simpson, J.] STFC Daresbury Lab, Warrington WA4 4AD, Cheshire, England. RP Hartley, DJ (reprint author), US Naval Acad, Dept Phys, Annapolis, MD 21402 USA. RI Carpenter, Michael/E-4287-2015; Ayangeakaa, Akaa/F-3683-2015 OI Carpenter, Michael/0000-0002-3237-5734; Ayangeakaa, Akaa/0000-0003-1679-3175 FU National Science Foundation [PHY-1203100, PHY-0754674, PHY-1068192]; U.S. Department of Energy, Office of Nuclear Physics [DE-AC02-06CH11357, DE-FG02-94ER40848, DE-FG02-96ER40983, DE-FG02-94ER40834, DE-FG02-95ER40939]; United Kingdom Science and Technology Facilities Council FX The authors thank the ANL operations staff at Gammasphere and gratefully acknowledge the efforts of J. P. Greene for target preparation. We thank D. C. Radford and H. Q. Jin for their software support. This work was funded by the National Science Foundation under Grants No. PHY-1203100 (USNA), No. PHY-0754674 (FSU), and No. PHY-1068192 (ND), the U.S. Department of Energy, Office of Nuclear Physics, under Contracts No. DE-AC02-06CH11357 (ANL), No. DE-FG02-94ER40848 (UML), No. DE-FG02-96ER40983 (UT), No. DE-FG02-94ER40834 (UMCP), and No. DE-FG02-95ER40939 (MSU), as well as the United Kingdom Science and Technology Facilities Council. NR 36 TC 1 Z9 1 U1 2 U2 13 PU AMER PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 0556-2813 EI 1089-490X J9 PHYS REV C JI Phys. Rev. C PD OCT 21 PY 2013 VL 88 IS 4 AR 044323 DI 10.1103/PhysRevC.88.044323 PG 15 WC Physics, Nuclear SC Physics GA 240KY UT WOS:000326096000003 ER PT J AU Hu, WG Hsieh, AJ AF Hu, Weiguo Hsieh, Alex J. TI Phase-mixing and molecular dynamics in poly(urethane urea) elastomers by solid-state NMR SO POLYMER LA English DT Article DE Poly(urethane urea); Nuclear magnetic resonance; Molecular dynamics ID MICROSTRUCTURE; CRYSTALLINITY; POLYURETHANE; SPECTROSCOPY; DEFORMATION; INFORMATION; COPOLYMERS; BEHAVIOR; SYSTEM AB The dynamical heterogeneity in a series of 4,4'-dicyclohexylmethane diisocyanate-diethyltoluenediamine-poly(tetramethylene oxide) based poly(urethane urea) (PUU) elastomers was studied by solid-state nuclear magnetic resonance (NMR) methods. Extensive phase mixing was evidenced by the H-1 wideline signal, which can be approximately fitted by a single exponential model. C-13 T-1 relaxation time measurements indicate that the hard segments (HS) exhibit some small-amplitude mobility, likely "activated" by neighboring soft segments (SS). Fitting of the time-domain wideline separation (TD-WISE) data was employed to characterize the extent of phase mixing, which revealed that a PUU elastomer contains four fractions: rigid-HS, mobile-HS, rigid-SS, and mobile-SS regions. For a variety of SS MWs, the dynamics and relative portions of rigid vs. mobile fractions among HS were substantially similar, while those for the SS exhibit large contrast. Furthermore, the dynamics in the rigid-SS fraction is at least an order of magnitude slower than that in mobile-SS. for all PUUs. Greater phase-mixing substantially lowers the SS mobility, facilitating SS to undergo glass transition at high strain rates, thus can be key to enhancing dynamic mechanical strengthening. (C) 2013 Elsevier Ltd. All rights reserved. C1 [Hu, Weiguo] Univ Massachusetts, Dept Polymer Sci & Engn, Amherst, MA 01003 USA. [Hsieh, Alex J.] US Army Res Lab, RDRL WMM G, Aberdeen Proving Ground, MD 21005 USA. RP Hu, WG (reprint author), Univ Massachusetts, Dept Polymer Sci & Engn, Amherst, MA 01003 USA. EM whu@data.pse.umass.edu NR 28 TC 6 Z9 6 U1 2 U2 28 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0032-3861 EI 1873-2291 J9 POLYMER JI Polymer PD OCT 18 PY 2013 VL 54 IS 22 BP 6218 EP 6225 DI 10.1016/j.polymer.2013.09.010 PG 8 WC Polymer Science SC Polymer Science GA 241BF UT WOS:000326140700021 ER PT J AU Keelapang, P Nitatpattana, N Suphatrakul, A Punyahathaikul, S Sriburi, R Pulmanausahakul, R Pichyangkul, S Malasit, P Yoksan, S Sittisombut, N AF Keelapang, Poonsook Nitatpattana, Narong Suphatrakul, Amporn Punyahathaikul, Surat Sriburi, Rungtawan Pulmanausahakul, Rojjanaporn Pichyangkul, Sathit Malasit, Prida Yoksan, Sutee Sittisombut, Nopporn TI Generation and preclinical evaluation of a DENV-1/2 prM + E chimeric live attenuated vaccine candidate with enhanced prM cleavage SO VACCINE LA English DT Article DE Dengue; Vaccine candidate; Live attenuated vaccine; prM cleavage; Monkey ID TETRAVALENT DENGUE VACCINE; ORIGINAL ANTIGENIC SIN; IN-DEPTH ANALYSIS; MONOCLONAL-ANTIBODIES; VIRUS-INFECTION; ENVELOPE GLYCOPROTEIN; CONSERVED RESIDUES; HEMORRHAGIC-FEVER; IMMUNE-RESPONSE; ECONOMIC-IMPACT AB In the absence of a vaccine or sustainable vector control measures, illnesses caused by dengue virus infection remain an important public health problem in many tropical countries. During the export of dengue virus particles, furin-mediated cleavage of the prM envelope protein is usually incomplete, thus generating a mixture of immature, partially mature and mature extracellular particles. Variations in the arrangement and conformation of the envelope proteins among these particles may be associated with their different roles in shaping the antibody response. In an attempt to improve upon live, attenuated dengue vaccine approaches, a mutant chimeric virus, with enhanced prM cleavage, was generated by introducing a cleavage-enhancing substitution into a chimeric DENV-1/2 virus genome, encoding the prM + E sequence of a recent DENV-1 isolate under an attenuated DENV-2 genetic background. A modest increase in virus specific infectivity observed in the mutant chimeric virus affected neither the attenuation phenotype, when assessed in the suckling mouse neurovirulence model, nor multiplication in mosquitoes. The two chimeric viruses induced similar levels of anti-DENV-1 neutralizing antibody response in mice and rhesus macaques, but more efficient control of viremia during viral challenge was observed in macaques immunized with the mutant chimeric virus. These results indicate that the DENV-1/2 chimeric virus, with enhanced prM cleavage, could be useful as an alternative live, attenuated vaccine candidate for further tests in humans. (C) 2013 Elsevier Ltd. All rights reserved. C1 [Keelapang, Poonsook; Sriburi, Rungtawan; Sittisombut, Nopporn] Chiang Mai Univ, Fac Med, Dept Microbiol, Chiang Mai 50200, Thailand. [Nitatpattana, Narong; Punyahathaikul, Surat; Yoksan, Sutee] Mahidol Univ, Inst Mol Biosci, Ctr Vaccine Dev, Salaya 73170, Nakhon Pathom, Thailand. [Suphatrakul, Amporn; Malasit, Prida; Sittisombut, Nopporn] Natl Sci & Technol Dev Agcy, Natl Ctr Genet Engn & Biotechnol, Med Biotechnol Res Unit, Bangkok 10400, Thailand. [Pulmanausahakul, Rojjanaporn] Mahidol Univ, Inst Mol Biosci, Virol Res Grp, Salaya 73170, Nakhon Pathom, Thailand. [Pichyangkul, Sathit] Armed Forces Res Inst Med Sci, Dept Immunol & Med, Bangkok 10400, Thailand. RP Yoksan, S (reprint author), Mahidol Univ, Inst Mol Biosci, Ctr Vaccine Dev, Salaya Campus,25-25 Putthamonthon 4 Rd, Salaya 73170, Nakhon Pathom, Thailand. EM grsys@mahidol.ac.th; nsittiso@mail.med.cmu.ac.th FU Initiative for Vaccine Research and Immunization, and Vaccine and Biologicals, WHO [V22/181/157]; Thailand-Tropical Diseases Research Program [02-2-DEN-03-003]; National Science and Technology Development Agency, Ministry of Science and Technology, Bangkok [P-00-10080, P-00-10556] FX This investigation received financial support from the Initiative for Vaccine Research and Immunization, and Vaccine and Biologicals, WHO (V22/181/157); Thailand-Tropical Diseases Research Program (02-2-DEN-03-003); and the National Science and Technology Development Agency, Ministry of Science and Technology, Bangkok (P-00-10080 and P-00-10556). NR 49 TC 5 Z9 5 U1 1 U2 6 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X EI 1873-2518 J9 VACCINE JI Vaccine PD OCT 17 PY 2013 VL 31 IS 44 BP 5134 EP 5140 DI 10.1016/j.vaccine.2013.08.027 PG 7 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 244CO UT WOS:000326364900020 PM 23973247 ER PT J AU Koehler, RN Alter, G Tovanabutra, S Saathoff, E Arroyo, MA Walsh, AM Sanders-Buell, EE Maboko, L Hoelscher, M Robb, ML Michael, NL McCutchan, FE Kim, JH Kijak, GH AF Koehler, Rebecca N. Alter, Galit Tovanabutra, Sodsai Saathoff, Elmar Arroyo, Miguel A. Walsh, Anne M. Sanders-Buell, Eric E. Maboko, Leonard Hoelscher, Michael Robb, Merlin L. Michael, Nelson L. McCutchan, Francine E. Kim, Jerome H. Kijak, Gustavo H. TI Natural Killer Cell-Mediated Innate Sieve Effect on HIV-1: The Impact of KIR/HLA Polymorphism on HIV-1 Subtype-Specific Acquisition in East Africa SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article DE HIV-1; innate immunity; KIR; HLA; sieve effect; subtypes; East Africa ID HLA; DIVERSITY; INDIVIDUALS; TANZANIA; COMPLEX; MBEYA AB Here we explore the association between killer cell immunoglobulin-like receptor (KIR)/HLA and human immunodeficiency virus type 1 (HIV-1) acquisition with different viral subtypes circulating in East Africa. In the prospective Cohort Development (CODE) cohort (Mbeya, Tanzania), carriers of KIR3DS1 and its putative ligand (HLA-A or HLA-B Bw4-80Ile alleles) showed increased HIV-1 acquisition risk (odds ratio [OR] = 3.46; 95% confidence interval [CI], 1.12-10.63; P =. 04) and a trend for enrichment for subtype A and A-containing recombinants (78% vs 46%; OR = 4.05; 95% CI,.91-28.30; P = .09) at the expense of subtype C (11% vs 43%; OR = 0.17; 95% CI,.01-.97; P = .08). In vitro, only natural killer cells from KIR3DS1(+)/HLA-Bw4-80Ile (+) healthy donors showed a 2-fold increased capacity to inhibit replication of subtype C vs subtype A viruses (P = .01). These findings suggest the presence of an innate sieve effect and may inform HIV-1 vaccine development. C1 [Koehler, Rebecca N.; Tovanabutra, Sodsai; Arroyo, Miguel A.; Walsh, Anne M.; Sanders-Buell, Eric E.; Robb, Merlin L.; Michael, Nelson L.; McCutchan, Francine E.; Kim, Jerome H.; Kijak, Gustavo H.] US Mil HIV Res Program, Rockville, MD USA. [Koehler, Rebecca N.; Tovanabutra, Sodsai; Walsh, Anne M.; Sanders-Buell, Eric E.; Robb, Merlin L.; McCutchan, Francine E.; Kijak, Gustavo H.] Henry M Jackson Fdn, Rockville, MD USA. [Alter, Galit] Harvard Univ, Ragon Inst, Massachusetts Gen Hosp, Boston, MA 02115 USA. [Alter, Galit] MIT, Boston, MA USA. [Saathoff, Elmar; Hoelscher, Michael] Univ Munich, Dept Infect Dis & Trop Med, D-81377 Munich, Germany. [Arroyo, Miguel A.; Michael, Nelson L.; Kim, Jerome H.] Walter Reed Army Inst Res, Div Retrovirol, Rockville, MD USA. [Maboko, Leonard; Hoelscher, Michael] NIMR Mbeya Med Res Programme, Mbeya, Tanzania. RP Kijak, GH (reprint author), Walter Reed Army Inst Res, US Mil HIV Res Program, Henry M Jackson Fdn, 503 Robert Grant Ave,Rm 2N27, Silver Spring, MD 20910 USA. EM gkijak@hivresearch.org RI Hoelscher, Michael/D-3436-2012; OI Arroyo, Miguel/0000-0001-7416-8867 FU Henry M. Jackson Foundation for the Advancement of Military Medicine; US Department of Defense (DOD); National Institute for Allergy and Infectious Diseases (NIAID); National Institutes of Health (NIH) [Y01 AI2642-12]; DOD; NIAID/NIH FX This work was supported through a cooperative agreement between the Henry M. Jackson Foundation for the Advancement of Military Medicine and the US Department of Defense (DOD), by the National Institute for Allergy and Infectious Diseases (NIAID), and National Institutes of Health (NIH; grant Y01 AI2642-12). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. The US Military HIV Research Program is jointly planned and funded by the DOD and NIAID/NIH by an interagency agreement. This manuscript was approved for publication by the Walter Reed Army Institute of Research. The views and opinions expressed herein are those of the authors and do not necessarily reflect those of the US Army or DOD or the NIH. NR 15 TC 4 Z9 4 U1 0 U2 7 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD OCT 15 PY 2013 VL 208 IS 8 BP 1250 EP 1254 DI 10.1093/infdis/jit349 PG 5 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 223TJ UT WOS:000324832800008 PM 23922366 ER PT J AU Picchioni, D Duyn, JH Horovitz, SG AF Picchioni, Dante Duyn, Jeff H. Horovitz, Silvina G. TI Sleep and the functional connectome SO NEUROIMAGE LA English DT Article DE Sleep; Connectivity; Memory; Arousal; Consciousness ID EYE-MOVEMENT SLEEP; SLOW-WAVE SLEEP; DEFAULT MODE NETWORK; DECLARATIVE MEMORY CONSOLIDATION; POSITRON-EMISSION-TOMOGRAPHY; PROPOFOL-INDUCED LOSS; CEREBRAL-BLOOD-FLOW; BRAIN ACTIVITY; K-COMPLEX; REM-SLEEP AB Sleep and the functional connectome are research areas with considerable overlap. Neuroimaging studies of sleep based on EEG-PET and EEG-fMRI are revealing the brain networks that support sleep, as well as networks that may support the roles and processes attributed to sleep. For example, phenomena such as arousal and consciousness are substantially modulated during sleep, and one would expect this modulation to be reflected in altered network activity. In addition, recent work suggests that sleep also has a number of adaptive functions that support waking activity. Thus the study of sleep may elucidate the circuits and processes that support waking function and complement information obtained from fMRI during waking conditions. In this review, we will discuss examples of this for memory, arousal, and consciousness after providing a brief background on sleep and on studying it with fMRI. Published by Elsevier Inc. C1 [Picchioni, Dante] Walter Reed Army Inst Res, Dept Behav Biol, Silver Spring, MD USA. [Duyn, Jeff H.] NINDS, Adv MRI, LFMI, NIH, Bethesda, MD 20892 USA. [Horovitz, Silvina G.] NINDS, Human Motor Control Sect, MNB, NIH, Bethesda, MD 20892 USA. RP Horovitz, SG (reprint author), NINDS, Human Motor Control Sect, Med Neurol Branch, NIH, 10 Ctr Dr,Bldg 10-7D37, Bethesda, MD 20892 USA. EM silvina.horovitz@nih.gov FU NIH National Institute of Neurological Disorders and Stroke; Walter Reed Army Institute of Research FX This work was supported by the Intramural Research Program of the NIH National Institute of Neurological Disorders and Stroke, and Walter Reed Army Institute of Research. NR 143 TC 27 Z9 28 U1 3 U2 54 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 1053-8119 J9 NEUROIMAGE JI Neuroimage PD OCT 15 PY 2013 VL 80 BP 387 EP 396 DI 10.1016/j.neuroimage.2013.05.067 PG 10 WC Neurosciences; Neuroimaging; Radiology, Nuclear Medicine & Medical Imaging SC Neurosciences & Neurology; Radiology, Nuclear Medicine & Medical Imaging GA 191MB UT WOS:000322416000032 PM 23707592 ER PT J AU Rinderspacher, BC AF Rinderspacher, B. Christopher TI Electro-optic and spectroscopic properties of push-pull-chromophores with non-aromatic pi-bridges SO CHEMICAL PHYSICS LETTERS LA English DT Article ID QUANTUM-CHEMICAL CALCULATIONS; DENSITY-FUNCTIONAL THEORY; ORBITAL METHODS; HYPERPOLARIZABILITIES; ACCEPTOR; ENERGIES; QSPR AB We present electronic structure calculations of the ultraviolet/visible (UV-Vis) spectra as well as hyper-polarizabilities (HP) of push-pull chromophores based on a donor-cyclic bridge-acceptor framework. The bridges are comprised of anti-aromatic polycycles or fulvalene analogues. Both UV/Vis and HP are sensitive functions of the conjugated framework and do not follow conventional wisdom, in particular for fulvalene analogues. Effects can be rationalized by determining mesomers of the bridge that can be stabilized or destabilized by the donor or acceptor. In particular, fulvalene analogues display high susceptibility to this effect and the strongest HP-chromophores exhibit a computed static hyperpolarizability of 372 x 10(-30) cm(5) esu(-1) and 311 x 10(-30) cm(5) esu(-1). Published by Elsevier B.V. C1 Army Res Lab, Weap & Mat Directorate, Aberdeen Proving Ground, MD 21005 USA. RP Rinderspacher, BC (reprint author), Army Res Lab, Weap & Mat Directorate, Aberdeen Proving Ground, MD 21005 USA. EM berend.c.rinderspacher.civ@mail.mil NR 30 TC 1 Z9 1 U1 0 U2 19 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0009-2614 J9 CHEM PHYS LETT JI Chem. Phys. Lett. PD OCT 14 PY 2013 VL 585 BP 21 EP 26 DI 10.1016/j.cplett.2013.08.082 PG 6 WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical SC Chemistry; Physics GA 228EQ UT WOS:000325169000004 ER PT J AU Convertino, M Foran, CM Keisler, JM Scarlett, L LoSchiavo, A Kiker, GA Linkov, I AF Convertino, Matteo Foran, Christy M. Keisler, Jeffrey M. Scarlett, Lynn LoSchiavo, Andy Kiker, Gregory A. Linkov, Igor TI Enhanced Adaptive Management: Integrating Decision Analysis, Scenario Analysis and Environmental Modeling for the Everglades SO SCIENTIFIC REPORTS LA English DT Article ID NATURAL-RESOURCE MANAGEMENT; CLIMATE-CHANGE; UNCERTAINTY; ADAPTATION; OPTIMIZATION; POLICY AB We propose to enhance existing adaptive management efforts with a decision-analytical approach that can guide the initial selection of robust restoration alternative plans and inform the need to adjust these alternatives in the course of action based on continuously acquired monitoring information and changing stakeholder values. We demonstrate an application of enhanced adaptive management for a wetland restoration case study inspired by the Florida Everglades restoration effort. We find that alternatives designed to reconstruct the pre-drainage flow may have a positive ecological impact, but may also have high operational costs and only marginally contribute to meeting other objectives such as reduction of flooding. Enhanced adaptive management allows managers to guide investment in ecosystem modeling and monitoring efforts through scenario and value of information analyses to support optimal restoration strategies in the face of uncertain and changing information. C1 [Convertino, Matteo; Foran, Christy M.; Linkov, Igor] United States Army Corps Engn, Engn Res & Dev Ctr, Vicksburg, MS USA. [Keisler, Jeffrey M.] Univ Massachusetts, Dept Management Sci & Informat Syst, Boston, MA 02125 USA. [Scarlett, Lynn] Resources Future Inc, Ctr Management Ecol Wealth, Washington, DC USA. [LoSchiavo, Andy] US Army Corps Engn, Planning Div, Environm Branch, Jacksonville, FL USA. [Kiker, Gregory A.] Univ Florida, Gainesville, FL USA. RP Linkov, I (reprint author), United States Army Corps Engn, Engn Res & Dev Ctr, Vicksburg, MS USA. EM Igor.Linkov@usace.army.mil FU Jacksonville District of the US Army Corps of Engineers; USACE Environmental Benefit Analysis (EBA) program FX The authors are grateful to Laure Canis for developing an initial version of the model. This study was funded be the Jacksonville District of the US Army Corps of Engineers and from the USACE Environmental Benefit Analysis (EBA) program. Permission was granted by the USACE Chief of Engineers to publish this material. The views and opinions expressed in this paper are those of the individual authors and not those of the U.S. Army, or other sponsor organizations. NR 58 TC 3 Z9 3 U1 3 U2 57 PU NATURE PUBLISHING GROUP PI LONDON PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND SN 2045-2322 J9 SCI REP-UK JI Sci Rep PD OCT 11 PY 2013 VL 3 AR UNSP 2922 DI 10.1038/srep02922 PG 9 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 233AN UT WOS:000325536600001 PM 24113217 ER PT J AU Vincenti, MA de Ceglia, D Haus, JW Scalora, M AF Vincenti, M. A. de Ceglia, D. Haus, J. W. Scalora, M. TI Harmonic generation in multiresonant plasma films SO PHYSICAL REVIEW A LA English DT Article ID 2ND-HARMONIC GENERATION; PERMITTIVITY; CONVERSION; MODES AB We investigate second- and third-harmonic generation in a slab of material that displays plasma resonances at the pump and its harmonic frequencies. Near-zero refractive indices and local field enhancement can deplete the pump for kW/cm(2) incident powers, without resorting to other resonant photonic mechanisms. We show that low-threshold, highly efficient nonlinear processes are possible in the presence of losses and phase mismatch in structures that are 10(4) times shorter than typical nonlinear crystals, for relatively low irradiance values. C1 [Vincenti, M. A.; de Ceglia, D.; Haus, J. W.] Natl Res Council AMRDEC, Charles M Bowden Res Lab, Redstone Arsenal, AL 35898 USA. [Haus, J. W.] Univ Dayton, Electroopt Program, Dayton, OH 45469 USA. [Scalora, M.] US Army RDECOM, Charles M Bowden Res Lab, AMRDEC, Redstone Arsenal, AL 35898 USA. RP Vincenti, MA (reprint author), Natl Res Council AMRDEC, Charles M Bowden Res Lab, Redstone Arsenal, AL 35898 USA. EM maria.vincenti@us.army.mil FU US Army Aviation and Missile Research Development and Engineering Center FX This research was performed while the authors M.A.V., D.d.C., and J.W.H. held a National Research Council Research Associateship award at the US Army Aviation and Missile Research Development and Engineering Center. NR 30 TC 11 Z9 11 U1 1 U2 5 PU AMER PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 1050-2947 EI 1094-1622 J9 PHYS REV A JI Phys. Rev. A PD OCT 10 PY 2013 VL 88 IS 4 AR 043812 DI 10.1103/PhysRevA.88.043812 PG 5 WC Optics; Physics, Atomic, Molecular & Chemical SC Optics; Physics GA 232LO UT WOS:000325495500003 ER PT J AU Mehta, AJ Letter, JV AF Mehta, Ashish J. Letter, Joseph V., Jr. TI Comments on the transition between cohesive and cohesionless sediment bed exchange SO ESTUARINE COASTAL AND SHELF SCIENCE LA English DT Article DE erosion; organic matter; sediment deposition; sediment rheology; viscoplasticity; yield stress ID MARINE SNOW; TRANSPORT; BEHAVIOR AB The presence of both cohesive and cohesionless particles in estuarine and lacustrine sediments makes it essential to model bed exchange of both types of particles. The usual practice is to select a purely empirical estimate of particle diameter marking the transition between the two behaviors. Based on available data on particle erosion and deposition in non-oscillating flows and viscoplastic properties of bed sediment, we have attempted to examine the likelihood of identifying the transition diameter within a less empirical framework. From the relationship between diameter and bed shear stress for a variety of cohesive and cohesionless sediments, it appears that two transition diameters can be defined. One is the largest diameter of clay mineral particles at which cohesion is considered to vanish. The other is the smallest diameter at which cohesionless behavior is assumed to end at the limit of the well-known Shields' relationship extended to very fine particles. These two diameters appear to be reasonably close for mainly inorganic mineral sediments. Assuming they are equal, six zones of bed exchange are identified in terms of diameter and bed shear stress. Depending on these two variables, zones of only erosion, no erosion or deposition, and only deposition can be designated. Realistic modeling of bed exchange of multi-size sediments requires that the full range of diameters be considered. Extension of this analysis to organic-rich sediments is pending better understanding of their rheological properties. Published by Elsevier Ltd. C1 [Mehta, Ashish J.] Univ Florida, Dept Civil & Coastal Engn, Gainesville, FL 32611 USA. [Letter, Joseph V., Jr.] US Army Engineer Res & Dev Ctr, Sebastian, FL 32958 USA. RP Letter, JV (reprint author), US Army Engineer Res & Dev Ctr, 681 Gossamer Wing Way, Sebastian, FL 32958 USA. EM Joseph.V.Letter@usace.army.mil NR 28 TC 3 Z9 3 U1 0 U2 14 PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD PI LONDON PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND SN 0272-7714 J9 ESTUAR COAST SHELF S JI Estuar. Coast. Shelf Sci. PD OCT 10 PY 2013 VL 131 BP 319 EP 324 DI 10.1016/j.ecss.2013.07.001 PG 6 WC Marine & Freshwater Biology; Oceanography SC Marine & Freshwater Biology; Oceanography GA 229ZC UT WOS:000325305400032 ER PT J AU Wren, JD Dozmorov, MG Burian, D Kaundal, R Perkins, A Perkins, E Kupfer, DM Springer, GK AF Wren, Jonathan D. Dozmorov, Mikhail G. Burian, Dennis Kaundal, Rakesh Perkins, Andy Perkins, Ed Kupfer, Doris M. Springer, Gordon K. TI Proceedings of the 2013 MidSouth Computational Biology and Bioinformatics Society (MCBIOS) Conference INTRODUCTION SO BMC BIOINFORMATICS LA English DT Editorial Material C1 [Wren, Jonathan D.; Dozmorov, Mikhail G.] Oklahoma Med Res Fdn, Arthrit & Immunol Res Program, Oklahoma City, OK 73104 USA. [Wren, Jonathan D.] Univ Okla Hlth Sci Ctr, Biochem & Mol Biol Dept, Oklahoma City, OK 73104 USA. [Burian, Dennis; Kupfer, Doris M.] FAA, Civil Aerosp Med Inst, Oklahoma City, OK 73169 USA. [Kaundal, Rakesh] Oklahoma State Univ, Dept Biochem & Mol Biol, Natl Inst Microbial Forens & Food & Agr Biosecur, Stillwater, OK 74078 USA. [Perkins, Andy] Mississippi State Univ, Dept Comp Sci & Engn, Mississippi State, MS 39762 USA. [Perkins, Ed] US Army Engn Res & Dev Ctr, Vicksburg, MS 39180 USA. [Springer, Gordon K.] Univ Missouri, Dept Comp Sci, Columbia, MO USA. RP Wren, JD (reprint author), Oklahoma Med Res Fdn, Arthrit & Immunol Res Program, 825 NE 13th St, Oklahoma City, OK 73104 USA. EM jdwren@gmail.com RI Kaundal, Rakesh/B-3071-2009 NR 17 TC 0 Z9 0 U1 2 U2 6 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1471-2105 J9 BMC BIOINFORMATICS JI BMC Bioinformatics PD OCT 9 PY 2013 VL 14 SU 14 AR UNSP S1 DI 10.1186/1471-2105-14-S14-S1 PG 5 WC Biochemical Research Methods; Biotechnology & Applied Microbiology; Mathematical & Computational Biology SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology; Mathematical & Computational Biology GA 249AA UT WOS:000326747100001 PM 24267415 ER PT J AU Yang, Y Maxwell, A Zhang, XW Wang, N Perkins, EJ Zhang, CY Gong, P AF Yang, Yi Maxwell, Andrew Zhang, Xiaowei Wang, Nan Perkins, Edward J. Zhang, Chaoyang Gong, Ping TI Differential reconstructed gene interaction networks for deriving toxicity threshold in chemical risk assessment SO BMC BIOINFORMATICS LA English DT Article; Proceedings Paper CT 10th Annual Conference of the MidSouth-Computational-Biology-and-Bioinformatics-Society (MCBIOS) on Discovery in a Sea of Data CY APR 05-06, 2013 CL Columbia, MO SP MidSouth Computat Biol & Bioinformat Soc ID STATE-SPACE MODEL; ESCHERICHIA-COLI; HIDDEN-VARIABLES; NEXT-GENERATION; CELL ARRAYS; TOXICOGENOMICS; IDENTIFY; LEVEL AB Background: Pathway alterations reflected as changes in gene expression regulation and gene interaction can result from cellular exposure to toxicants. Such information is often used to elucidate toxicological modes of action. From a risk assessment perspective, alterations in biological pathways are a rich resource for setting toxicant thresholds, which may be more sensitive and mechanism-informed than traditional toxicity endpoints. Here we developed a novel differential networks (DNs) approach to connect pathway perturbation with toxicity threshold setting. Methods: Our DNs approach consists of 6 steps: time-series gene expression data collection, identification of altered genes, gene interaction network reconstruction, differential edge inference, mapping of genes with differential edges to pathways, and establishment of causal relationships between chemical concentration and perturbed pathways. A one-sample Gaussian process model and a linear regression model were used to identify genes that exhibited significant profile changes across an entire time course and between treatments, respectively. Interaction networks of differentially expressed (DE) genes were reconstructed for different treatments using a state space model and then compared to infer differential edges/interactions. DE genes possessing differential edges were mapped to biological pathways in databases such as KEGG pathways. Results: Using the DNs approach, we analyzed a time-series Escherichia coli live cell gene expression dataset consisting of 4 treatments (control, 10, 100, 1000 mg/L naphthenic acids, NAs) and 18 time points. Through comparison of reconstructed networks and construction of differential networks, 80 genes were identified as DE genes with a significant number of differential edges, and 22 KEGG pathways were altered in a concentration-dependent manner. Some of these pathways were perturbed to a degree as high as 70% even at the lowest exposure concentration, implying a high sensitivity of our DNs approach. Conclusions: Findings from this proof-of-concept study suggest that our approach has a great potential in providing a novel and sensitive tool for threshold setting in chemical risk assessment. In future work, we plan to analyze more time-series datasets with a full spectrum of concentrations and sufficient replications per treatment. The pathway alteration-derived thresholds will also be compared with those derived from apical endpoints such as cell growth rate. C1 [Yang, Yi; Maxwell, Andrew; Wang, Nan; Zhang, Chaoyang] Univ So Mississippi, Sch Comp, Hattiesburg, MS 39406 USA. [Zhang, Xiaowei] Nanjing Univ, State Key Lab Pollut Control & Resource Reuse, Nanjing 210008, Jiangsu, Peoples R China. [Zhang, Xiaowei] Nanjing Univ, Sch Environm, Nanjing 210008, Jiangsu, Peoples R China. [Perkins, Edward J.] US Army Engn Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA. [Gong, Ping] Badger Tech Serv LLC, San Antonio, TX 78216 USA. RP Zhang, CY (reprint author), Univ So Mississippi, Sch Comp, Hattiesburg, MS 39406 USA. EM Chaoyang.Zhang@usm.edu; Ping.Gong@usace.army.mil OI Zhang, Xiaowei/0000-0001-8974-9963 NR 33 TC 4 Z9 4 U1 0 U2 12 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1471-2105 J9 BMC BIOINFORMATICS JI BMC Bioinformatics PD OCT 9 PY 2013 VL 14 SU 14 AR S3 DI 10.1186/1471-2105-14-S14-S3 PG 9 WC Biochemical Research Methods; Biotechnology & Applied Microbiology; Mathematical & Computational Biology SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology; Mathematical & Computational Biology GA 249AA UT WOS:000326747100003 PM 24268022 ER PT J AU Spring, M Murphy, J Nielse, R Dowler, M Bennett, JW Zarling, S Williams, J de la Vega, P Ware, L Komisar, J Polhemus, M Richie, TL Epstein, J Tamminga, C Chuang, I Richie, N O'Neil, M Heppner, DG Healer, J O'Neill, M Smithers, H Finney, OC Mikolajczak, SA Wang, RB Cowman, A Ockenhouse, C Krzych, U Kappe, SHI AF Spring, Michele Murphy, Jittawadee Nielse, Robin Dowler, Megan Bennett, Jason W. Zarling, Stasya Williams, Jack de la Vega, Patricia Ware, Lisa Komisar, Jack Polhemus, Mark Richie, Thomas L. Epstein, Judy Tamminga, Cindy Chuang, Ilin Richie, Nancy O'Neil, Michael Heppner, D. Gray Healer, Julie O'Neill, Matthew Smithers, Hannah Finney, Olivia C. Mikolajczak, Sebastian A. Wang, Ruobing Cowman, Alan Ockenhouse, Christian Krzych, Urszula Kappe, Stefan H. I. TI First-in-human evaluation of genetically attenuated Plasmodium falciparum sporozoites administered by bite of Anopheles mosquitoes to adult volunteers SO VACCINE LA English DT Article DE Genetically attenuated parasite; First-in-human; Malaria; Plasmodium falciparum ID MALARIA VACCINE DEVELOPMENT; MEMORY T-CELLS; PROTECTIVE IMMUNITY; LIVER; IMMUNIZATION; MECHANISMS; CHALLENGE; INFECTION; RADIATION; PARASITES AB Background: Immunization with genetically engineered, attenuated malaria parasites (GAP) that arrest during liver infection confers sterile protection in mouse malaria models. A first generation Plasmodium falciparum GAP (Pf p52(-)/p36(-) GAP) was previously generated by deletion of two pre-erythrocytic stage-expressed genes (P52 and P36) in the NF54 strain. Methods: A first-in-human, proof-of-concept, safety and immunogenicity clinical trial in six human volunteers was conducted. Exposure consisted of delivery of Pf p52-/p36- GAP sporozoites via infected Anopheles mosquito bite with a five-bite/volunteer exposure followed by an approximately 200-bite exposure/volunteer one month later. Results: The exposures were well tolerated with mild to moderate local and systemic reactions. All volunteers remained blood stage negative after low dose exposure. Five volunteers remained blood stage negative after high dose exposure. One volunteer developed peripheral parasitemia twelve days after high dose exposure. Together the findings indicate that Pf p52-/p36- GAP was severely but not completely attenuated. All six volunteers developed antibodies to CSP. Furthermore, IFN-gamma responses to whole sporozoites and multiple antigens were elicited in 5 of 6 volunteers, with both CD4 and CD8 cell cytokine production detected. Conclusion: Severe attenuation and favorable immune responses following administration of a first generation Pf p52-/p36- GAP suggests that further development of live-attenuated strains using genetic engineering should be pursued. (C) 2013 Elsevier Ltd. All rights reserved. C1 [Spring, Michele; Murphy, Jittawadee; Nielse, Robin; Dowler, Megan; Bennett, Jason W.; Zarling, Stasya; Williams, Jack; de la Vega, Patricia; Ware, Lisa; Komisar, Jack; Polhemus, Mark; Richie, Nancy; O'Neil, Michael; Heppner, D. Gray; Ockenhouse, Christian; Krzych, Urszula] Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. [Richie, Thomas L.; Epstein, Judy; Tamminga, Cindy; Chuang, Ilin] Naval Malaria Res Ctr, Silver Spring, MD 20910 USA. [Healer, Julie; O'Neill, Matthew; Cowman, Alan] Walter & Eliza Hall Inst Med Res, Melbourne, Vic 3052, Australia. [Smithers, Hannah; Finney, Olivia C.; Mikolajczak, Sebastian A.; Wang, Ruobing; Kappe, Stefan H. I.] Seattle Biomed Res Inst, Seattle, WA 98109 USA. [Kappe, Stefan H. I.] Univ Washington, Dept Global Hlth, Seattle, WA 98195 USA. RP Kappe, SHI (reprint author), Seattle Biomed Res Inst, 4 Nickerson St, Seattle, WA 98109 USA. EM stefan.kappe@seattlebiomed.org OI Richie, Thomas/0000-0002-2946-5456; Mikolajczak, Sebastian/0000-0003-1996-9703 FU Foundation for the National Institutes of Health through the Grand Challenges in Global Health Initiative; US Army Medical Research and Materiel Command FX The research was funded by a Grant from the Foundation for the National Institutes of Health through the Grand Challenges in Global Health Initiative to SHIK and US Army Medical Research and Materiel Command. The opinions or assertions contained herein are the private views of the authors, and are not to be construed as official or as reflecting the views of the Department of the Army or the Department of Defense. We would like to thank members of Statistics Collaborative, Inc. for their help with the study and Ashley M. Vaughan for editorial suggestions. NR 39 TC 46 Z9 46 U1 1 U2 20 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X EI 1873-2518 J9 VACCINE JI Vaccine PD OCT 9 PY 2013 VL 31 IS 43 BP 4975 EP 4983 DI 10.1016/j.vaccine.2013.08.007 PG 9 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 242PV UT WOS:000326255400008 PM 24029408 ER PT J AU Munday, LB Mitchell, RL Knap, J Chung, PW AF Munday, Lynn B. Mitchell, Robert L. Knap, Jaroslaw Chung, Peter W. TI Role of molecule flexibility on the nucleation of dislocations in molecular crystals SO APPLIED PHYSICS LETTERS LA English DT Article ID CRACK-TIP; CYCLOTRIMETHYLENE TRINITRAMINE; FORCE-FIELD; SLIP PLANES; NANOINDENTATION; SIMULATIONS; PLASTICITY; HARDNESS; SOLIDS; SHEAR AB We show that a molecule's flexibility described by changes to its conformation and orientation during deformation is vital for the proper representation of dislocation nucleation in molecular crystals. This is shown for the molecular crystal hexahydro-1,3,5-trinitro-s-triazine (RDX) by comparing direct atomistic simulations to two alternate forms of a continuum dislocation nucleation model for a crack tip loaded in pure shear. The atomistic simulations show the emission of partial dislocations. These are compared to continuum dislocation nucleation models based on generalized stacking fault (GSF) energy surfaces where the molecules are allowed to be either rigid or flexible. The rigid molecules are unable to represent the partial dislocations whereas the flexible molecules agree with the direct atomistic model to within 17% of the stress intensity factor for emission of the first partial dislocation and to within 1% for the second partial. This agreement first indicates that the molecule flexibility serves a critical role in the ductile behavior of the molecular crystal and, second, the continuum dislocation nucleation model represents the correct atomistic behavior, showing two partial dislocations connected by a stacking fault, when parameterized with GSF energy surfaces that account for the molecule flexibility. (C) 2013 AIP Publishing LLC. C1 [Munday, Lynn B.; Knap, Jaroslaw; Chung, Peter W.] US Army Res Lab, Computat & Informat Sci Directorate, Aberdeen Proving Ground, MD 21005 USA. [Mitchell, Robert L.] Univ Calif Irvine, Dept Mech Engn, Irvine, CA 92717 USA. RP Munday, LB (reprint author), US Army Res Lab, Computat & Informat Sci Directorate, Aberdeen Proving Ground, MD 21005 USA. EM lynn.munday@us.army.mil FU DoD High Performance Computing Modernization Office through the Multiscale Reactive Modeling of Insensitive Munitions Software Applications Institute FX Support of the DoD High Performance Computing Modernization Office through the Multiscale Reactive Modeling of Insensitive Munitions Software Applications Institute is gratefully acknowledged. Computing resources were provided by the DoD Supercomputing Resource Center located at the US Army Research Laboratory. NR 27 TC 6 Z9 6 U1 0 U2 14 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0003-6951 EI 1077-3118 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD OCT 7 PY 2013 VL 103 IS 15 AR 151911 DI 10.1063/1.4824711 PG 4 WC Physics, Applied SC Physics GA 236FD UT WOS:000325779700036 ER PT J AU Mascioni, M Ghosh, NN Sands, JM Palmese, GR AF Mascioni, Matteo Ghosh, Narendra N. Sands, James M. Palmese, Giuseppe R. TI Electron beam and UV cationic polymerization of glycidyl ethers - PART I: Reaction of monofunctional phenyl glycidyl ether SO JOURNAL OF APPLIED POLYMER SCIENCE LA English DT Article DE kinetics; photopolymerization; ring-opening polymerization; spectroscopy ID EPOXY-RESINS; BISPHENOL-A; CALORIMETRY TECHNIQUE; DIARYLIODONIUM SALTS; DIGLYCIDYL ETHER; COMPLEXES; COMPOSITES; MONOMER; AMINE; MODEL AB Investigations of electron beam (e-beam) and ultra violet (UV)-induced cationic polymerization kinetics of a mono-functional epoxy system, phenyl glycidyl ether (PGE), were conducted using real time in situ near infrared (NIR) spectroscopy. Effects of processing variables such as temperature and dose rate on initiation and propagation rate constants have been assessed. The experimental results and results from a simple mathematical model developed to predict the reaction behavior under continuous irradiation showed very good agreement. This work provides a basis for investigating the cure behavior of more complex and industrially relevant crosslinking epoxy systems where diffusion limitations play an important role as discussed in PART II. (c) 2013 Wiley Periodicals, Inc. J. Appl. Polym. Sci., 2013 C1 [Mascioni, Matteo; Ghosh, Narendra N.; Palmese, Giuseppe R.] Drexel Univ, Dept Chem & Biol Engn, Philadelphia, PA 19104 USA. [Ghosh, Narendra N.] Birla Inst Technol & Sci Pilani, Dept Chem, Zuarinagar 403726, Goa, India. [Sands, James M.] US Army Res Lab, Mat & Mfg Sci Div, Aberdeen Proving Ground, MD 21005 USA. RP Palmese, GR (reprint author), Drexel Univ, Dept Chem & Biol Engn, Philadelphia, PA 19104 USA. EM grp27@drexel.edu FU U.S. Army Research Laboratory (ARL); Strategic Environmental Research and Development Program (SERDP) FX The authors gratefully acknowledge the support of Dr. Mark Wilenski and Mr. James Beymer of the Boeing Company for providing support for the e-beam irradiation and measurements and financial support from U.S. Army Research Laboratory (ARL) and Strategic Environmental Research and Development Program (SERDP) "Non Polluting Composites Repair and Remanufacturing For Military Applications - PP1109". NN Ghosh is thankful to BITS Pilani for granting sabbatical leave. NR 33 TC 3 Z9 3 U1 3 U2 38 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0021-8995 J9 J APPL POLYM SCI JI J. Appl. Polym. Sci. PD OCT 5 PY 2013 VL 130 IS 1 BP 479 EP 486 DI 10.1002/app.39184 PG 8 WC Polymer Science SC Polymer Science GA 176LI UT WOS:000321305500057 ER PT J AU Mascioni, M Ghosh, NN Sands, JM Palmese, GR AF Mascioni, Matteo Ghosh, Narendra N. Sands, James M. Palmese, Giuseppe R. TI Electron beam and UV cationic polymerization of glycidyl ethers PART II: Reaction of diglycidyl ether of bisphenol A SO JOURNAL OF APPLIED POLYMER SCIENCE LA English DT Article DE kinetics; photopolymerization; spectroscopy ID EPOXY-RESINS; GLASS-TRANSITION; COMPOSITES; DIFFUSION; MODEL; CURE; KINETICS AB Electron-beam (e-beam) and ultraviolet (UV)-induced cationic polymerization of diglycidyl ether of bisphenol A (DGEBA) using the photo-initiator diaryliodonium hexafluoroantimonate was investigated using in situ NIR spectroscopy. The effect of processing parameters, such as temperature, radiation intensity, and photo-initiator concentration, on kinetics of the reaction were determined quantitatively. In contrast to the behavior of monofunctional epoxy systems reported previously, the difunctional epoxy forms a high T-g crosslinked network, so a kinetic model that takes into account diffusion limitations associated with vitrification was developed. The combined benefits of the real-time in situ NIR spectroscopy study and the well-defined diffusion model resulted in very accurate predictions for cure of epoxy networks by e-beam-induced polymerization. The results support the view that e-beam processing of epoxies is constrained by vitrification in the same way that UV and thermally cured epoxies are. (c) 2013 Wiley Periodicals, Inc. J. Appl. Polym. Sci., 2013 C1 [Mascioni, Matteo; Ghosh, Narendra N.; Palmese, Giuseppe R.] Drexel Univ, Dept Chem & Biol Engn, Philadelphia, PA 19104 USA. [Ghosh, Narendra N.] Birla Inst Technol & Sci Pilani, Dept Chem, Zuarinagar 403726, Goa, India. [Sands, James M.] US Army Res Lab, Mat & Mfg Sci Div, Aberdeen Proving Ground, MD 21005 USA. RP Palmese, GR (reprint author), Drexel Univ, Dept Chem & Biol Engn, Philadelphia, PA 19104 USA. EM grp27@drexel.edu FU U.S. Army Research Laboratory (ARL); Strategic Environmental Research and Development Program (SERDP) FX Authors gratefully acknowledge Dr. Mark Wilenski and Mr. James Beymer of the Boeing Company for providing support for the electron beam irradiation and measurements as well as financial support from U.S. Army Research Laboratory (ARL) and Strategic Environmental Research and Development Program (SERDP) "Non Polluting Composites Repair and Remanufacturing For Military Applications - PP1109." NN Ghosh is thankful to BITS Pilani for granting sabbatical leave. NR 24 TC 3 Z9 3 U1 2 U2 38 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0021-8995 J9 J APPL POLYM SCI JI J. Appl. Polym. Sci. PD OCT 5 PY 2013 VL 130 IS 1 BP 487 EP 495 DI 10.1002/app.39189 PG 9 WC Polymer Science SC Polymer Science GA 176LI UT WOS:000321305500058 ER PT J AU Darling, KA Roberts, AJ Mishin, Y Mathaudhu, SN Kecskes, LJ AF Darling, K. A. Roberts, A. J. Mishin, Y. Mathaudhu, S. N. Kecskes, L. J. TI Grain size stabilization of nanocrystalline copper at high temperatures by alloying with tantalum SO JOURNAL OF ALLOYS AND COMPOUNDS LA English DT Article DE Nanocrystalline alloys; Grain-growth; Binary alloys; Stability; Thermal analysis; Immiscible systems ID THERMAL-STABILITY; MICROSTRUCTURAL EVOLUTION; THERMOKINETIC DESCRIPTION; SOLUTE SEGREGATION; TRIPLE JUNCTIONS; GROWTH; CU; SYSTEM; ENERGY; NANOSTRUCTURES AB Nanocrystalline Cu-Ta alloys belong to an emerging class of immiscible materials with potential for high-temperature applications. Differential scanning calorimetry (DSC), Vickers microhardness, transmission and scanning electron microscopy (TEM/SEM), and atomistic simulations have been applied to study the structural evolution in high-energy cryogenically alloyed nanocrystalline Cu-10 at.%Ta. The thermally induced coarsening of the as-milled microstructure was investigated and it was found that the onset of grain growth occurs at temperatures higher than that for pure nanocrystalline Cu. The total heat release associated with grain growth was 0.553 kJ/mol. Interestingly, nanocrystalline Cu-10 at.%Ta maintains a mean grain size (GS) of 167 nm after annealing at 97% of its melting point. The increased microstructural stability is attributed to a combination of thermodynamic and kinetic stabilization effects which, in turn, appear to be controlled by segregation and diffusion of Ta solute atoms along grain boundaries (GBs). The as-milled nanocrystalline Cu-10 at.% Ta exhibits Vickers microhardness values near 5 GPa surpassing the microhardness of conventional pure nanocrystalline Cu by similar to 2.5 GPa. Published by Elsevier B.V. C1 [Darling, K. A.; Kecskes, L. J.] USA, Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. [Roberts, A. J.] USA, ORISE Program, Res Lab, Aberdeen Proving Ground, MD 21005 USA. [Mishin, Y.] George Mason Univ, Dept Phys & Astron, Fairfax, VA 22030 USA. [Mathaudhu, S. N.] USA, Res Lab, Army Res Off, Res Triangle Pk, NC 27709 USA. RP Darling, KA (reprint author), USA, Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. EM kristopher.darling.civ@mail.mil RI Kecskes, Laszlo/F-6880-2014; Mathaudhu, Suveen/B-4192-2009; Mishin, Yuri/P-2020-2015 OI Kecskes, Laszlo/0000-0002-1342-3729; FU Strategic Environmental Research and Development Program, Arlington VA [WP-2139] FX The authors would like to thank the Strategic Environmental Research and Development Program, 901 North Stuart Street, Arlington VA 2203 for funding this effort under Project Number WP-2139. NR 80 TC 32 Z9 33 U1 11 U2 118 PU ELSEVIER SCIENCE SA PI LAUSANNE PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND SN 0925-8388 J9 J ALLOY COMPD JI J. Alloy. Compd. PD OCT 5 PY 2013 VL 573 BP 142 EP 150 DI 10.1016/j.jallcom.2013.03.177 PG 9 WC Chemistry, Physical; Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Chemistry; Materials Science; Metallurgy & Metallurgical Engineering GA 166VC UT WOS:000320585700023 ER PT J AU Lambeth, RH Henderson, TJ AF Lambeth, Robert H. Henderson, Terry J. TI Organocatalytic synthesis of (poly)hydroxyurethanes from cyclic carbonates and amines SO POLYMER LA English DT Article DE Polyhydroxyurethane; Organocatalyst; Cyclic carbonate ID RING-OPENING POLYMERIZATION; N-HETEROCYCLIC CARBENES; LIVING POLYMERIZATION; DIETHYL CARBONATE; MODEL REACTION; POLYURETHANES; POLYADDITION; ESTERS; TBD; POLYHYDROXYURETHANES AB The organocatalyzed aminolysis of cyclic carbonates to form (poly)hydroxyurethanes is an important reaction as an alternative to isocyanate based chemistries. In an effort to increase reaction rates between cyclic carbonates and amines to lower cure times and increase molecular weights, various organocatalysts were surveyed. Reaction rates between monofunctional model cyclic carbonates and amines were determined in the presence of a variety of organocatalysts, which operate under different mechanisms to promote the reaction. Of the catalysts investigated, TBD was the most potent, presumably due to its bifunctional activity. TBD was also used to promote step-growth polymerization between difunctional cyclic carbonates and amines. The polymers produced in the presence of TBD at room temperature were much higher in molecular weight than polymers produced in the absence of catalyst at both room temperature and at 80 degrees C. Published by Elsevier Ltd. C1 [Lambeth, Robert H.] US Army Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. [Henderson, Terry J.] US Army Edgewood Chem Biol Ctr, Biochem Branch, Biosci Directorate, RDCB DRB C, Aberdeen Proving Ground, MD 21010 USA. RP Lambeth, RH (reprint author), US Army Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. EM Robert.h.lambeth2.civ@mail.mil NR 52 TC 34 Z9 34 U1 7 U2 82 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0032-3861 EI 1873-2291 J9 POLYMER JI Polymer PD OCT 4 PY 2013 VL 54 IS 21 BP 5568 EP 5573 DI 10.1016/j.polymer.2013.08.053 PG 6 WC Polymer Science SC Polymer Science GA 241YI UT WOS:000326204200015 ER PT J AU De Lucia, FC Gottfried, JL AF De Lucia, Frank C., Jr. Gottfried, Jennifer L. TI Influence of Molecular Structure on the Laser-Induced Plasma Emission of the Explosive RDX and Organic Polymers SO JOURNAL OF PHYSICAL CHEMISTRY A LA English DT Article ID INDUCED BREAKDOWN SPECTROSCOPY; AMBIENT AIR; PLASTIC IDENTIFICATION; ABLATION; NITROGEN; LIBS; GRAPHITE; RESIDUES; PLUME; DISCRIMINATION AB A series of organic polymers and the military explosive cyclotrimethylenetrinitramine (RDX) were studied using the light emission from a femtosecond laser induced plasma under an argon atmosphere. The relationship between the molecular structure and plasma emission was established by using the percentages of the atomic species (C, H, N, O) and bond types (C-C, C=C, C-N, and C N) in combination with the atomic/molecular emission intensities and decay rates. In contrast to previous studies of organic explosives in which C-2 was primarily formed by recombination, for the organic materials in this study the percentage of C-C (and C=C) bonds was strongly correlated to the molecular, C-2 emission. Time-resolved emission spectra were collected to determine the lifetimes of the atomic and molecular species in the plasma. Observed differences in decay rates Were attributed to the differences in both the molecular structure of the organic polymers or;RDX and the chemical reactions that occur within the plasma. These differences could potentially be exploited to improve the discrimination of explosive residues on organic substrates with laser induced breakdown spectroscopy. C1 [De Lucia, Frank C., Jr.; Gottfried, Jennifer L.] US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP De Lucia, FC (reprint author), US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA. EM frank.c.delucia.civ@mail.mil RI Gottfried, Jennifer/G-6333-2010; De Lucia, Frank/D-5630-2012 NR 34 TC 8 Z9 8 U1 5 U2 47 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1089-5639 EI 1520-5215 J9 J PHYS CHEM A JI J. Phys. Chem. A PD OCT 3 PY 2013 VL 117 IS 39 BP 9555 EP 9563 DI 10.1021/jp312236h PG 9 WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical SC Chemistry; Physics GA 243EV UT WOS:000326300600028 PM 23862752 ER PT J AU Bennett, JW Pybus, BS Yadava, A Tosh, D Sousa, JC McCarthy, WF Deye, G Melendez, V Ockenhouse, CF AF Bennett, Jason W. Pybus, Brandon S. Yadava, Anjali Tosh, Donna Sousa, Jason C. McCarthy, William F. Deye, Gregory Melendez, Victor Ockenhouse, Christian F. TI Primaquine Failure and Cytochrome P-450 2D6 in Plasmodium vivax Malaria SO NEW ENGLAND JOURNAL OF MEDICINE LA English DT Letter AB Primaquine is used to eradicate the hepatic or hypnozoite form of Plasmodium vivax that may lead to relapse of infection. Host genetic factors may play a role in the activity of primaquine therapy.To the Editor: Primaquine is the only medication approved by the Food and Drug Administration to eradicate the hypnozoites of Plasmodium vivax, but relapses of P. vivax malaria due to drug failure occur.(1) Human cytochrome P-450 isoenzyme 2D6 (CYP2D6) may be a key enzyme involved in metabolizing primaquine into redox-active metabolites against hypnozoites in the liver.(2),(3) As part of a phase 1 clinical trial of a vaccine against P. vivax (Study of VMP001 and AS01B in Healthy Malaria-Naive Adults; ClinicalTrials.gov number, NCT01157897), 33 participants were exposed to P. vivax sporozoites from the bites of infected mosquitoes. Parasitemia developed in ... C1 [Bennett, Jason W.; Pybus, Brandon S.; Yadava, Anjali; Tosh, Donna; Sousa, Jason C.; Deye, Gregory; Melendez, Victor; Ockenhouse, Christian F.] Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. [McCarthy, William F.] US Army Med Mat Dev Act, Frederick, MD USA. RP Bennett, JW (reprint author), Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. EM jason.w.bennett.mil@mail.mil RI Sousa, Jason/A-9177-2011 NR 5 TC 54 Z9 55 U1 1 U2 13 PU MASSACHUSETTS MEDICAL SOC PI WALTHAM PA WALTHAM WOODS CENTER, 860 WINTER ST,, WALTHAM, MA 02451-1413 USA SN 0028-4793 J9 NEW ENGL J MED JI N. Engl. J. Med. PD OCT 3 PY 2013 VL 369 IS 14 BP 1381 EP 1382 DI 10.1056/NEJMc1301936 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA 227KI UT WOS:000325111200022 PM 24088113 ER PT J AU Friedl, KE O'Neil, HF AF Friedl, Karl E. O'Neil, Harold F. TI Designing and Using Computer Simulations in Medical Education and Training: An Introduction SO MILITARY MEDICINE LA English DT Editorial Material ID TRAUMA; TEAM; TECHNOLOGY; MILITARY; CARE AB Computer-based technologies informed by the science of learning are becoming increasingly prevalent in education and training. For the Department of Defense (DoD), this presents a great potential advantage to the effective preparation of a new generation of technologically enabled service members. Military medicine has broad education and training challenges ranging from first aid and personal protective skills for every service member to specialized combat medic training; many of these challenges can be met with gaming and simulation technologies that this new generation has embraced. However, comprehensive use of medical games and simulation to augment expert mentorship is still limited to elite medical provider training programs, but can be expected to become broadly used in the training of first responders and allied health care providers. The purpose of this supplement is to review the use of computer games and simulation to teach and assess medical knowledge and skills. This review and other DoD research policy sources will form the basis for development of a research and development road map and guidelines for use of this technology in military medicine. C1 [Friedl, Karl E.] US Army Med Res & Mat Command, Telemed & Adv Technol Res Ctr, Ft Detrick, MD 21702 USA. [O'Neil, Harold F.] Univ So Calif, Rossier Sch Educ, Natl Ctr Res Evaluat Stand & Student Testing CRES, Sherman Oaks, CA 91403 USA. RP Friedl, KE (reprint author), US Army Med Res & Mat Command, Telemed & Adv Technol Res Ctr, Ft Detrick, MD 21702 USA. OI Friedl, Karl/0000-0002-3134-8427 NR 44 TC 5 Z9 7 U1 0 U2 12 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD OCT PY 2013 VL 178 IS 10 SU S SI SI BP 1 EP 6 DI 10.7205/MILMED-D-13-00209 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA AN7UG UT WOS:000340805900002 PM 24084299 ER PT J AU Platteborze, PL Kippenberger, DJ Martin, TM AF Platteborze, Peter L. Kippenberger, Donald J. Martin, Thomas M. TI Drug Positive Rates for the Army, Army Reserve, and Army National Guard From Fiscal Year 2001 through 2011 SO MILITARY MEDICINE LA English DT Article AB Objective: To examine the overall and drug-specific positive rates of Army urinalysis specimens tested from fiscal year 2001 (FY01) through FY11. Methods: We analyzed annual Army Forensic Toxicology Drug Testing Laboratory results from FY01 to FY11. Results: From FY01 to FY11, the Army's positive rate was 1.06%. The component rates were 0.84%, 1.53%, and 1.94% for the active duty, Reserve, and National Guard, respectively. The Army's average positive rate for marijuana from FY01 to FY11 was 0.79%, and the cocaine rate was 0.26%. From FY06 to FY11, the average positive rate for oxycodone was 0.74% and the d-amphetamine rate was 0.30%. Apart from oxymorphone, a key metabolite of oxycodone, the positive rate for all other drugs tested was below 0.25%. The FY11 drug positive rates in decreasing order were oxymorphone > oxycodone > marijuana > d-amphetamine > codeine > cocaine > morphine > d-methamphetamine > methylenedioxymethamphetamine > heroin > methylenedioxyamphetamine > phencyclidine. Although the drug positive rate for heroin remains low, the number of positives has increased dramatically since FY05. Conclusion: The drug-testing program continues to serve as a vital deterrent as evidenced by the Army's overall positive rate being well below the 8.9% estimated illicit use in the civilian population. C1 [Platteborze, Peter L.; Kippenberger, Donald J.; Martin, Thomas M.] US Army Med Command, ATTN MCHO CL H, Ft Sam Houston, TX 78234 USA. RP Platteborze, PL (reprint author), US Army Med Command, ATTN MCHO CL H, 2748 Worth Rd,Bldg 2748, Ft Sam Houston, TX 78234 USA. NR 8 TC 6 Z9 6 U1 0 U2 2 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD OCT PY 2013 VL 178 IS 10 BP 1078 EP 1084 DI 10.7205/MILMED-D-13-00193 PG 7 WC Medicine, General & Internal SC General & Internal Medicine GA AN7UD UT WOS:000340805600008 PM 24083921 ER PT J AU Crowder, TA Ferrara, AL Levinbook, MD AF Crowder, Todd A. Ferrara, Andrew L. Levinbook, Max D. TI Creation of a Criterion-Referenced Military Optimal Performance Challenge SO MILITARY MEDICINE LA English DT Article ID PHYSICAL-FITNESS TESTS; BODY-MASS BIAS; LOAD-CARRIAGE; SOLDIER PERFORMANCE; AIR-FORCE; STRENGTH; ARMY; NAVY; MEN AB Purpose: To compare an empirical, Army doctrine-based (endurance, strength, mobility, military relevant tasks), criterion-referenced, body mass (BM) unbiased Military Optimal Performance Challenge (MOPC) to the Army's Physical Fitness Test (APFT) and thus assisting commanders to determine military readiness. Methods: Militarily-relevant physical assessments were combined to create a composite MOPC score. The MOPC and APFT were administered to 20 male, military subjects during a 2-week period. Data collection included 3-Mile Run, Mobility Test, Upper/Lower Body Strength/Endurance, Simulated Casualty Evacuation Test. The APFT was administered through Army guidelines before MOPC data collection. Results: The APFT was influenced by BM, lean body mass (LBM) (r = 0.44; r(2) = 0.20; p = 0.04), whereas MOPC was less impacted (r = 0.21; r(2) = 0.04; p = 0.32). Eight subjects, as viewed by %APFT, are "fit for duty" (80.6%); however, all eight subjects' mean score as %MOPC was < 50%. Conclusions: The MOPC offers a robust approach to military readiness and is free of the confounding influence of BM. The MOPC is a unique assessment requiring a multitude of abilities to garner success and may assist in training for functional combat performance skills demanding high work capacities. C1 [Crowder, Todd A.] US Mil Acad, Dept Phys Educ, West Point, NY 10996 USA. [Ferrara, Andrew L.; Levinbook, Max D.] Schofield Barracks, Infantry Div 25, Oahu, HI 96857 USA. RP Crowder, TA (reprint author), US Mil Acad, Dept Phys Educ, West Point, NY 10996 USA. NR 25 TC 1 Z9 1 U1 0 U2 4 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD OCT PY 2013 VL 178 IS 10 BP 1085 EP 1101 DI 10.7205/MILMED-D-13-00081 PG 17 WC Medicine, General & Internal SC General & Internal Medicine GA AN7UD UT WOS:000340805600009 PM 24083922 ER PT J AU Niebuhr, DW Page, WF Cowan, DN Urban, N Gubata, ME Richard, P AF Niebuhr, David W. Page, William F. Cowan, David N. Urban, Nadia Gubata, Marlene E. Richard, Patrick TI Cost-Effectiveness Analysis of the U.S. Army Assessment of Recruit Motivation and Strength (ARMS) Program SO MILITARY MEDICINE LA English DT Article ID UNITED-STATES; PREACCESSION FITNESS; TRAINING INJURIES; PHYSICAL-FITNESS; OBESITY; OVERWEIGHT; PREVALENCE; ATTRITION; PREDICTORS; TRAINEES AB The Assessment of Recruit Motivation and Strength (ARMS) Study was conducted at six Military Entrance Processing Sites during 2005-2006. The objectives were to compare morbidity and attrition of Army accessions who exceeded body fat (EBF) accession standards compared to weight for height or body fat qualified (WQ) and to compare among the WQ subset, those who were physically fit as measured by a 5-minute step test compared to unfit. We performed a cost-effectiveness analysis to address both objectives. Analysis was performed by gender with the primary outcomes of musculoskeletal injury and attrition. Results were expressed in terms of cost per year of military service. Sensitivity analysis was performed on probability cost estimates. We found WQ female recruits were $5,141 less expensive per year than EBF female recruits. WQ males were $2,785 less expensive per year of military service than EBF male recruits. Among WQ recruits, fit females were $3,638 and fit males were $10,381 less expensive per year of service than their unfit counterparts. The ARMS step test is a cost-effective method to identify physically fit EBF applicants for accession in weak recruiting environments. It also offers a cost-effective method to reduce poor physical fitness associated morbidity and attrition. C1 [Niebuhr, David W.; Richard, Patrick] Uniformed Serv Univ Hlth Sci, Dept Prevent Med & Biometr, Bethesda, MD 20814 USA. [Page, William F.; Cowan, David N.; Urban, Nadia] Allied Technol Grp Inc, Rockville, MD 20850 USA. [Page, William F.; Cowan, David N.; Urban, Nadia; Gubata, Marlene E.] Walter Reed Army Inst Res, Prevent Med Branch, Silver Spring, MD 20910 USA. RP Niebuhr, DW (reprint author), Uniformed Serv Univ Hlth Sci, Dept Prevent Med & Biometr, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA. FU United States Army Accession Command FX We thank Ms. Janice Gary and Ms. Vielka Rivera, Accession Medical Standards Analysis & Research Activity (AMSARA), Walter Reed Army Institute of Research, for their administrative support. This study was funded by the United States Army Accession Command. NR 22 TC 3 Z9 3 U1 0 U2 3 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD OCT PY 2013 VL 178 IS 10 BP 1102 EP 1110 DI 10.7205/MILMED-D-13-00108 PG 9 WC Medicine, General & Internal SC General & Internal Medicine GA AN7UD UT WOS:000340805600010 PM 24083923 ER PT J AU Welles, AP Buller, MJ Margolis, L Economos, D Hoyt, RW Richter, MW AF Welles, Alexander P. Buller, Mark J. Margolis, Lee Economos, Demetri Hoyt, Reed W. Richter, Mark W. TI Thermal-Work Strain During Marine Rifle Squad Operations in Afghanistan SO MILITARY MEDICINE LA English DT Article ID AEROBIC PERFORMANCE; HEAT-STRESS; TEMPERATURE; DEHYDRATION; MECHANISMS AB The physiological burden created by heat strain and physical exercise, also called thermal-work strain, was quantified for 10 male Marines (age 21.9 +/- 2.3 years, height 180.3 +/- 5.2 cm, and weight 85.2 +/- 10.8 kg) during three dismounted missions in Helmand Province, Afghanistan. Heart rate (BR) and core body temperature (T-core) were recorded every 15 seconds (Equivital EQ-01; Hidalgo, Cambridge, United Kingdom) during periods of light, moderate, and heavy work and used to estimate metabolic rate. Meteorological measures, clothing characteristics, anthropometrics, and estimated metabolic rates were used to predict T-core for the same missions during March (spring) and July (summer) conditions. Thermal-work strain was quantified from HR and T-core values using the Physiological Strain Index (PSI) developed by Moran et al. July PSI and T-core values were predicted and not observed due to lack of access to in-theater warfighters at that time. Our methods quantify and compare the predicted and observed thermal-work strain resulting from environment and worn or carried equipment and illustrate that a small increase in ambient temperature and solar load might result in increased thermal-work strain. C1 [Welles, Alexander P.; Buller, Mark J.; Margolis, Lee; Hoyt, Reed W.] US Army Res Inst Environm Med, Biophys & Biomed Modeling Div, Natick, MA 01760 USA. [Economos, Demetri; Richter, Mark W.] Marine Corps Syst Command, Marine Expeditionary Rifle Squad, Quantico, VA 22134 USA. RP Welles, AP (reprint author), US Army Res Inst Environm Med, Biophys & Biomed Modeling Div, 44 Kansas St,Bldg 42, Natick, MA 01760 USA. NR 26 TC 5 Z9 5 U1 0 U2 13 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD OCT PY 2013 VL 178 IS 10 BP 1141 EP 1148 DI 10.7205/MlLMED-D-12-00538 PG 8 WC Medicine, General & Internal SC General & Internal Medicine GA AN7UD UT WOS:000340805600017 PM 24083930 ER PT J AU Gross, J Doan, M Yamada, S Kloetzel, M Morgan, S Gilbert, B Balatbat, L Johnston, D Park, S AF Gross, J. Doan, M. Yamada, S. Kloetzel, M. Morgan, S. Gilbert, B. Balatbat, L. Johnston, D. Park, S. TI MYCOBACTERIUM ABCESSUS EPIDEMIC AMONG CYSTIC FIBROSIS PATIENTS SO PEDIATRIC PULMONOLOGY LA English DT Meeting Abstract C1 [Gross, J.; Doan, M.; Yamada, S.; Kloetzel, M.; Morgan, S.; Gilbert, B.; Balatbat, L.] Tripler Army Med Ctr, Honolulu, HI 96859 USA. [Johnston, D.; Park, S.] Hawaii State Dept Hlth, Honolulu, HI USA. NR 0 TC 4 Z9 4 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 8755-6863 EI 1099-0496 J9 PEDIATR PULM JI Pediatr. Pulmonol. PD OCT PY 2013 VL 48 SU 36 BP 302 EP 303 PG 2 WC Pediatrics; Respiratory System SC Pediatrics; Respiratory System GA AF0FB UT WOS:000334387200350 ER PT J AU Theodore, CR Tischler, MB AF Theodore, Colin R. Tischler, Mark B. TI Development and Operation of an Automatic Rotor Trim Control System for the UH-60 Individual Blade Control Wind Tunnel Test SO JOURNAL OF THE AMERICAN HELICOPTER SOCIETY LA English DT Article ID HELICOPTER AB An automatic rotor trim control system was developed and used successfully during a wind tunnel test of a full-scale UH-60 rotor system with individual blade control (IBC) actuators. The trim control system allowed rotor trim to be set more quickly, precisely, and repeatably than in previous wind tunnel tests. This control system also allowed the rotor trim state to be maintained during transients and drift in wind tunnel flow and through changes in IBC actuation. The ability to maintain a consistent rotor trim state was key to quickly and accurately evaluating the effect of IBC on rotor performance, vibration, noise, and loads. This paper presents details of the design and implementation of the trim control system including the rotor system hardware, trim control requirements, and trim control hardware and software implementation. Results are presented showing the effect of IBC on rotor trim and dynamic response, a validation of the rotor dynamic simulation used to calculate the initial control gains and tuning of the control system, and the overall performance of the trim control system during the wind tunnel test. C1 [Theodore, Colin R.] NASA, Ames Res Ctr, Moffett Field, CA 94035 USA. [Tischler, Mark B.] US Army RDECOM, Aeroflightdynam Directorate AMRDEC, Moffett Field, CA USA. RP Theodore, CR (reprint author), NASA, Ames Res Ctr, Moffett Field, CA 94035 USA. EM ctheodore@mail.arc.nasa.gov NR 11 TC 0 Z9 0 U1 2 U2 7 PU AMER HELICOPTER SOC INC PI ALEXANDRIA PA 217 N WASHINGTON ST, ALEXANDRIA, VA 22314 USA SN 0002-8711 EI 2161-6027 J9 J AM HELICOPTER SOC JI J. Am. Helicopter Soc. PD OCT PY 2013 VL 58 IS 4 AR 042007 DI 10.4050/JAHS.58.042007 PG 13 WC Engineering, Aerospace SC Engineering GA AB5MY UT WOS:000331834000007 ER PT J AU Brown, K Bacon, B Balart, L Bernstein, D Brown, R Flamm, S Harrison, S Kugelmas, M Kwo, P LaBrecque, D Neff, G Patel, V Reau, N Reddy, R Regenstein, F Schiff, E Shiffman, M Poordad, F AF Brown, Kim Bacon, Bruce Balart, Luis Bernstein, David Brown, Robert Flamm, Steven Harrison, Stephen Kugelmas, Marcelo Kwo, Paul LaBrecque, Douglas Neff, Guy Patel, Vishal Reau, Nancy Reddy, Rajender Regenstein, Fredric Schiff, Eugene Shiffman, Mitchell Poordad, Fred TI Hepatitis C Therapy in Community Practice (OPTIMAL): An Educational Partnership Program between Academic and Community Practices SO AMERICAN JOURNAL OF GASTROENTEROLOGY LA English DT Meeting Abstract CT 78th Annual Scientific Meeting of the American-College-of-Gastroenterology CY OCT 11-16, 2013 CL San Diego, CA SP Amer Coll Gastroenterol C1 [Brown, Kim] Henry Ford Hosp, Detroit, MI 48202 USA. [Bacon, Bruce] St Louis Univ, Sch Med, St Louis, MO USA. [Balart, Luis] Tulane Univ, Sch Med, New Orleans, LA 70112 USA. [Bernstein, David] Hofstra North Shore Sch Med, Manhasset, NY USA. [Brown, Robert] Columbia Univ Coll Phys & Surg, New York Presbyterian Hosp, New York, NY 10032 USA. [Flamm, Steven] Northwestern Univ, Feinberg Sch Med, Chicago, IL 60611 USA. [Harrison, Stephen] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. [Kugelmas, Marcelo] South Denver Gastroenterol, Englewood, CO USA. [Kwo, Paul] Indiana Univ Sch Med, Indianapolis, IN 46202 USA. [LaBrecque, Douglas] Univ Iowa, Sch Med, Iowa City, IA 52242 USA. [Neff, Guy] Tampa Gen Med Grp, Tampa, FL USA. [Patel, Vishal] Temple Univ, Sch Med, Philadelphia, PA 19122 USA. [Reau, Nancy] Univ Chicago, Med Ctr, Chicago, IL 60637 USA. [Reddy, Rajender] Univ Penn, Sch Med, Philadelphia, PA 19104 USA. [Regenstein, Fredric] St Lukes Hosp, Kansas City, MO USA. [Schiff, Eugene] Univ Miami, Sch Med, Miami, FL USA. [Shiffman, Mitchell] Liver Inst Virginia, Richmond, VA USA. [Poordad, Fred] Univ Texas Hlth Sci Ctr San Antonio, Texas Liver Inst, San Antonio, TX 78229 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 0002-9270 EI 1572-0241 J9 AM J GASTROENTEROL JI Am. J. Gastroenterol. PD OCT PY 2013 VL 108 SU 1 MA 408 BP S122 EP S122 PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 296II UT WOS:000330178100408 ER PT J AU Poordad, F Rustgi, V Brown, R Patel, V Kugelmas, M Regenstein, F Balart, L LaBrecque, D Brown, K Avila, M Biederman, M Freed, G Smith, R Bernstein, M Arnold, H Cahan, J Fink, S Katkov, W Massoumi, H Harrison, S AF Poordad, Fred Rustgi, Vinod Brown, Robert Patel, Vishal Kugelmas, Marcelo Regenstein, Fredric Balart, Luis LaBrecque, Douglas Brown, Kim Avila, Mark Biederman, Michael Freed, Glenn Smith, Richard Bernstein, Marc Arnold, Hays Cahan, Joel Fink, Scott Katkov, William Massoumi, Hatef Harrison, Stephen TI Boceprevir (BOC) in Community Practice: Interim Results on Early Response and Safety from the OPTIMAL Trial SO AMERICAN JOURNAL OF GASTROENTEROLOGY LA English DT Meeting Abstract CT 78th Annual Scientific Meeting of the American-College-of-Gastroenterology CY OCT 11-16, 2013 CL San Diego, CA SP Amer Coll Gastroenterol C1 [Poordad, Fred] Univ Texas Hlth Sci Ctr San Antonio, Texas Liver Inst, San Antonio, TX 78229 USA. [Rustgi, Vinod] Metropolitan Res, Fairfax, VA USA. [Brown, Robert] Columbia Univ Coll Phys & Surg, New York Presbyterian Hosp, New York, NY 10032 USA. [Patel, Vishal] Temple Univ, Sch Med, Philadelphia, PA 19122 USA. [Kugelmas, Marcelo] South Denver Gastroenterol, Englewood, CO USA. [Regenstein, Fredric] St Lukes Hosp, Kansas City, MO USA. [Balart, Luis] Tulane Univ, Sch Med, New Orleans, LA 70112 USA. [LaBrecque, Douglas] Univ Iowa, Sch Med, Iowa City, IA 52242 USA. [Brown, Kim] Henry Ford Hosp, Detroit, MI 48202 USA. [Avila, Mark] Digest Med Associates, Hialeah, FL USA. [Biederman, Michael] South Oakland Gastroenterol Associates, Farmington Hills, MI USA. [Smith, Richard] Flint Gastroenterol Associates, Grand Blanc, MI USA. [Bernstein, Marc] Mercy Clin Hepatol, St Louis, MO USA. [Arnold, Hays] Gastroenterol Consultants San Antonio, San Antonio, TX USA. [Cahan, Joel] Consultants Gastroenterol, Munster, IN USA. [Fink, Scott] Main Line Gastroenterol Associates, Wynnewood, PA USA. [Katkov, William] St Johns Hlth Ctr, Santa Monica, CA USA. [Massoumi, Hatef] New York Associates Gastroenterol, Bronx, NY USA. [Harrison, Stephen] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 0002-9270 EI 1572-0241 J9 AM J GASTROENTEROL JI Am. J. Gastroenterol. PD OCT PY 2013 VL 108 SU 1 MA 406 BP S121 EP S121 PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 296II UT WOS:000330178100406 ER PT J AU Tamminga, C Sedegah, M Maiolatesi, S Fedders, C Reyes, S Reyes, A Vasquez, C Alcorta, Y Chuang, I Spring, M Kavanaugh, M Ganeshan, H Huang, J Belmonte, M Abot, E Belmonte, A Banania, J Farooq, F Murphy, J Komisar, J Richie, NO Bennett, J Limbach, K Patterson, NB Bruder, JT Shi, M Miller, E Dutta, S Diggs, C Soisson, LA Hollingdale, MR Epstein, JE Richie, TL AF Tamminga, Cindy Sedegah, Martha Maiolatesi, Santina Fedders, Charlotte Reyes, Sharina Reyes, Anatalio Vasquez, Carlos Alcorta, Yolanda Chuang, Ilin Spring, Michele Kavanaugh, Michael Ganeshan, Harini Huang, Jun Belmonte, Maria Abot, Esteban Belmonte, Arnel Banania, JoGlenna Farooq, Fouzia Murphy, Jittawadee Komisar, Jack Richie, Nancy O. Bennett, Jason Limbach, Keith Patterson, Noelle B. Bruder, Joseph T. Shi, Meng Miller, Edward Dutta, Sheetij Diggs, Carter Soisson, Lorraine A. Hollingdale, Michael R. Epstein, Judith E. Richie, Thomas L. TI Human adenovirus 5-vectored Plasmodium falciparum NMRC-M3V-Ad-PfCA vaccine encoding CSP and AMA1 is safe, well-tolerated and immunogenic but does not protect against controlled human malaria infection SO HUMAN VACCINES & IMMUNOTHERAPEUTICS LA English DT Article DE malaria; vaccine; adenovirus; efficacy; antibody; T cells ID LIVER-STAGE MALARIA; CD8(+) T-CELLS; CIRCUMSPOROZOITE PROTEIN; DNA VACCINE; IMMUNIZATION; RESPONSES; TOLERABILITY; MEMORY; INDUCTION; EFFICACY AB Background: In a prior study, a DNA prime/adenovirus boost vaccine (DNA/Ad) expressing P. falciparum circumsporozoite protein (CS P) and apical membrane antigen-1 (AMA1) (NMRC-M3V-D/Ad-PfCA Vaccine) induced 27% protection against controlled human malaria infection (CHMI). To investigate the contribution of DNA priming, we tested the efficacy of adenovirus vaccine alone (NMRC-M3V-Ad-PfCA) in a phase 1 clinical trial. Methodology/Principal Findings: The regimen was a single intramuscular injection with two non-replicating human serotype 5 adenovectors encoding CS P and AMA1, respectively. An amount of 1 x 10(10) particle units of each construct were combined prior to administration. The regimen was safe and well-tolerated. Four weeks later, 18 study subjects received P. falciparum CHMI administered by mosquito bite. None were fully protected although one showed delayed onset of parasitemia. Antibody responses were low, with geometric mean CS P ELISA titer of 381 (range <50-1626) and AMA1 ELISA of 4.95 mu g/mL (range 0.2-38). Summed ex vivo IFN-gamma ELISpot responses to overlapping peptides were robust, with geometric mean spot forming cells/million peripheral blood mononuclear cells [sfc/m] for CS P of 273 (range 38-2550) and for AMA1 of 1303 (range 435-4594). CD4(+) and CD8(+) T cell IFN-gamma responses to CS P were positive by flow cytometry in 25% and 56% of the research subjects, respectively, and to AMA1 in 94% and 100%, respectively. Significance: In contrast to DNA/Ad, Ad alone did not protect against CHMI despite inducing broad, cell-mediated immunity, indicating that DNA priming is required for protection by the adenovirus-vectored vaccine. ClinicalTrials.gov Identifier: NCT00392015. C1 [Tamminga, Cindy; Sedegah, Martha; Maiolatesi, Santina; Fedders, Charlotte; Reyes, Sharina; Reyes, Anatalio; Vasquez, Carlos; Alcorta, Yolanda; Chuang, Ilin; Ganeshan, Harini; Huang, Jun; Belmonte, Maria; Abot, Esteban; Belmonte, Arnel; Banania, JoGlenna; Farooq, Fouzia; Limbach, Keith; Patterson, Noelle B.; Hollingdale, Michael R.; Epstein, Judith E.; Richie, Thomas L.] Naval Med Res Ctr, Silver Spring, MD 20910 USA. [Spring, Michele] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Kavanaugh, Michael; Miller, Edward] Natl Naval Med Ctr, Bethesda, MD USA. [Murphy, Jittawadee; Komisar, Jack; Richie, Nancy O.; Bennett, Jason; Shi, Meng; Dutta, Sheetij] Walter Reed Army Inst Res, Silver Spring, MD USA. [Bruder, Joseph T.] GenVec Inc, Gaithersburg, MD USA. [Diggs, Carter; Soisson, Lorraine A.] USAID, Washington, DC USA. RP Tamminga, C (reprint author), Naval Med Res Ctr, Silver Spring, MD 20910 USA. EM Cindy.Tamminga@med.navy.mil OI Richie, Thomas/0000-0002-2946-5456 FU USAID "Development of Adenovirus-Vectored Malaria Vaccines" Grant [GHA-P-00-03-00006-01, 936-3118]; Congressionally Directed Medical Research Program "Development of Recombinant Adenoviral-based Vaccines against Malaria"Grant [W81XWH-05-2-0041]; Military Infectious Disease Research Program (MIDRP) [62787A 870 F 1432] FX This work was supported by (1) USAID "Development of Adenovirus-Vectored Malaria Vaccines" Grant #: GHA-P-00-03-00006-01, Project Number 936-3118; (2) the Congressionally Directed Medical Research Program "Development of Recombinant Adenoviral-based Vaccines against Malaria" Grant #: W81XWH-05-2-0041; and (3) the Military Infectious Disease Research Program (MIDRP) project "Phase 1/2a clinical trials assessing the safety, tolerability, immunogenicity & protective efficacy of Ad5-CA, a two-antigen, adenovirus-vectored Plasmodium falciparum malaria vaccine, in healthy, malaria-naive adults," work unit number 62787A 870 F 1432. NR 32 TC 17 Z9 17 U1 0 U2 1 PU LANDES BIOSCIENCE PI AUSTIN PA 1806 RIO GRANDE ST, AUSTIN, TX 78702 USA SN 2164-5515 EI 2164-554X J9 HUM VACC IMMUNOTHER JI Human Vaccines Immunother. PD OCT PY 2013 VL 9 IS 10 BP 2165 EP 2177 DI 10.4161/hv.24941 PG 13 WC Biotechnology & Applied Microbiology; Immunology SC Biotechnology & Applied Microbiology; Immunology GA 299FQ UT WOS:000330381600024 PM 23899517 ER PT J AU Lawnick, MM Champion, HR Gennarelli, T Galarneau, MR D'Souza, E Vickers, RR Wing, V Eastridge, BJ Young, LA Dye, J Spott, MA Jenkins, DH Holcomb, J Blackbourne, LH Ficke, JR Kalin, EJ Flaherty, S AF Lawnick, Mary M. Champion, Howard R. Gennarelli, Thomas Galarneau, Michael R. D'Souza, Edwin Vickers, Ross R. Wing, Vern Eastridge, Brian J. Young, Lee Ann Dye, Judy Spott, Mary Ann Jenkins, Donald H. Holcomb, John Blackbourne, Lorne H. Ficke, James R. Kalin, Ellen J. Flaherty, Stephen TI Combat injury coding: A review and reconfiguration SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY LA English DT Review DE Combat; trauma; injury severity scoring; impairment ID SEVERITY SCORE; SCALE; PREDICTOR; MORTALITY; DEATH; CARE; WAR AB BACKGROUND: The current civilian Abbreviated Injury Scale (AIS), designed for automobile crash injuries, yields important information about civilian injuries. It has been recognized for some time, however, that both the AIS and AIS-based scores such as the Injury Severity Score (ISS) are inadequate for describing penetrating injuries, especially those sustained in combat. Existing injury coding systems do not adequately describe (they actually exclude) combat injuries such as the devastating multi-mechanistic injuries resulting from attacks with improvised explosive devices (IEDs). METHODS: After quantifying the inapplicability of current coding systems, the Military Combat Injury Scale (MCIS), which includes injury descriptors that accurately characterize combat anatomic injury, and the Military Functional Incapacity Scale (MFIS), which indicates immediate tactical functional impairment, were developed by a large tri-service military and civilian group of combat trauma subject-matter experts. Assignment of MCIS severity levels was based on urgency, level of care needed, and risk of death from each individual injury. The MFIS was developed based on the casualty's ability to shoot, move, and communicate, and comprises four levels ranging from "Able to continue mission" to "Lost to military." Separate functional impairments were identified for injuries aboard ship. Preliminary evaluation of MCIS discrimination, calibration, and casualty disposition was performed on 992 combat-injured patients using two modeling processes. RESULTS: Based on combat casualty data, the MCIS is a new, simpler, comprehensive severity scale with 269 codes (vs. 1999 in AIS) that specifically characterize and distinguish the many unique injuries encountered in combat. The MCIS integrates with the MFIS, which associates immediate combat functional impairment with minor and moderate-severity injuries. Predictive validation on combat datasets shows improved performance over AIS-based tools in addition to improved face, construct, and content validity and coding inter-rater reliability. Thus, the MCIS has greater relevance, accuracy, and precision for many military-specific applications. CONCLUSION: Over a period of several years, the Military Combat Injury Scale and Military Functional Incapacity Scale were developed, tested and validated by teams of civilian and tri-service military expertise. MCIS shows significant promise in documenting the nature, severity and complexity of modern combat injury. Copyright (C) 2013 by Lippincott Williams & Wilkins C1 [Lawnick, Mary M.; Champion, Howard R.; Kalin, Ellen J.] SimQuest Solut Inc, Dept Surg, Annapolis, MD USA. [Champion, Howard R.] Uniformed Serv Univ Hlth Sci, Bestheda, MD USA. [Gennarelli, Thomas] Med Coll Wisconsin, Milwaukee, WI 53226 USA. [Galarneau, Michael R.; D'Souza, Edwin; Vickers, Ross R.; Wing, Vern; Dye, Judy] Naval Hlth Res Ctr, San Diego, CA USA. [Spott, Mary Ann; Blackbourne, Lorne H.] US Army Inst Surg Res, San Antonio, TX USA. [Holcomb, John] Univ Texas Hlth Sci Ctr, San Antonio, TX USA. [Ficke, James R.] Brooke Army Med Ctr, San Antonio, TX USA. [Young, Lee Ann] Appl Res Associates, Albuquerque, NM USA. [Jenkins, Donald H.] Mayo Clin, Rochester, MN USA. [Flaherty, Stephen] Walter Reed Army Med Ctr, Washington, DC 20307 USA. RP Champion, HR (reprint author), 954 Melvin Rd, Annapolis, MD USA. EM hrchampion@aol.com FU Office of Naval Research [N00014-07-C-0076, N00014-11-C-0061] FX This material is based on work supported by the Office of Naval Research, Advanced Requirements for Crew Safety (ARCS) under Contract No. N00014-07-C-0076 and Human Injury and Treatment under Contract No. N00014-11-C-0061 NR 25 TC 6 Z9 6 U1 0 U2 6 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 2163-0755 EI 2163-0763 J9 J TRAUMA ACUTE CARE JI J. Trauma Acute Care Surg. PD OCT PY 2013 VL 75 IS 4 BP 573 EP 581 DI 10.1097/TA.0b013e3182a53bc6 PG 9 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 300IK UT WOS:000330457400005 PM 24064868 ER PT J AU Feldt, B Dion, GR Weitzel, EK McMains, KC AF Feldt, Brent Dion, Gregory R. Weitzel, Erik K. McMains, Kevin C. TI Acute Sinusitis SO SOUTHERN MEDICAL JOURNAL LA English DT Review DE acute sinusitis; bacterial sinusitis; nasal airway obstruction; purulent rhinorrhea; sinusitis ID ACUTE BACTERIAL RHINOSINUSITIS; ANTIMICROBIAL THERAPY; CONTROLLED TRIAL; DOUBLE-BLIND; ADULTS; METAANALYSIS; ANTIBIOTICS; AMOXICILLIN; DIAGNOSIS; RHINITIS AB Sinusitis is a common patient complaint that carries with it a large economic burden. It is one of the most common reasons patients visit their primary care physician. Acute bacterial rhinosinusitis (ABRS) can be distinguished from other forms of rhinosinusitis based on symptom duration of <4 weeks in a patient with purulent rhinorrhea associated with facial pain or pressure. Native upper aerodigestive tract bacteria are the most common etiologic agents. Treatment of ABRS is targeted primarily at symptom improvement. Amoxicillin can be used based on the clinical scenario and patient comorbidities. Computed tomographic scans are reserved for complicated presentations or when there is concern for intracranial extension or other complications. A systematic approach to ABRS will allow for improved patient quality of life and a decreased overall economic burden of this common entity. C1 Wilford Hall Ambulatory Surg Ctr, San Antonio, TX USA. Brooke Army Med Ctr, San Antonio Mil Med Ctr, Ft Sam Houston, TX 78234 USA. Audie L Murphy Mem Vet Adm Med Ctr, South Texas Vet Hlth Care, San Antonio, TX 78284 USA. RP Dion, GR (reprint author), ATTN MCHE SDT Oto, Dept Otolaryngol, 3551 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM greg.r.dion@us.army.mil NR 32 TC 0 Z9 0 U1 1 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0038-4348 EI 1541-8243 J9 SOUTH MED J JI South.Med.J. PD OCT PY 2013 VL 106 IS 10 BP 577 EP 581 DI 10.1097/SMJ.0000000000000002 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA 298UK UT WOS:000330349800007 PM 24096952 ER PT J AU Walker, M AF Walker, Mark TI High Kick to Sprinter's Lunge SO STRENGTH AND CONDITIONING JOURNAL LA English DT Article AB This column provides a detailed description with figures to demonstrate the high kick to sprinter's lunge. The high kick to sprinter's lunge is a dynamic flexibility exercise that can be used as part of a warm-up program to provide active stretching for the lower extremities and to improve hip mobility. C1 US Army, Musculoskeletal Act Team, Proxy Personnel, Ft Sill, OK 73503 USA. RP Walker, M (reprint author), US Army, Musculoskeletal Act Team, Proxy Personnel, Ft Sill, OK 73503 USA. NR 0 TC 0 Z9 0 U1 1 U2 4 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1524-1602 EI 1533-4295 J9 STRENGTH COND J JI Strength Cond. J. PD OCT PY 2013 VL 35 IS 5 BP 68 EP 69 PG 2 WC Sport Sciences SC Sport Sciences GA 299CR UT WOS:000330373200012 ER PT J AU Demarest, J Pagsuyoin, S Learmonth, G Mellor, J Dillingham, R AF Demarest, Jeffrey Pagsuyoin, Sheree Learmonth, Gerard Mellor, Jonathan Dillingham, Rebecca TI Development of a Spatial and Temporal Agent-Based Model for Studying Water and Health Relationships: The Case Study of Two Villages in Limpopo, South Africa SO JASSS-THE JOURNAL OF ARTIFICIAL SOCIETIES AND SOCIAL SIMULATION LA English DT Article DE Agent-Based Model; Water Quality; Early Childhood Diarrhea; Stunting ID EARLY-CHILDHOOD DIARRHEA; POINT-OF-USE; DEVELOPING-COUNTRIES; SYSTEMATIC ANALYSIS; HYGIENE INTERVENTIONS; SANITATION; CHILDREN; DISEASE; BURDEN; METAANALYSIS AB Diarrhea, the second leading cause of child morbidity and mortality, can have detrimental effects in the physical and cognitive development of children in developing countries. Health interventions (e.g., increased access to health services and safe water) designed to address this problem are difficult to implement in resource-limited settings. In this paper, we present a tool for understanding the complex relationship between water and public health in rural areas of a developing country. A spatial and temporal agent-based model (ABM) was developed to simulate the current water, sanitation, and health status in two villages in Limpopo Province, South Africa. The model was calibrated using empirical data and published sources. It was used to simulate the effects of poor water quality on the frequency of diarrheal episodes in children, and consequently on child development. Preliminary simulation results show that at the current total coliform levels in the water sources of the studied villages, children are expected to experience stunting by as much as -1.0 standard deviations from the World Health Organization height norms. With minor modifications, the calibrated ABM can be used to design and evaluate intervention strategies for improving child health in these villages. The model can also be applied to other regions worldwide that face the same environmental challenges and conditions as the studied villages. C1 [Demarest, Jeffrey] US Mil Acad, Dept Syst Engn, West Point, NY 10996 USA. [Pagsuyoin, Sheree] Univ Waterloo, Dept Civil & Environm Engn, Waterloo, ON N2L 3G1, Canada. [Learmonth, Gerard] Univ Virginia, Charlottesville, VA 22904 USA. [Mellor, Jonathan] Univ Virginia, Dept Civil & Environm Engn, Charlottesville, VA 22904 USA. [Dillingham, Rebecca] Univ Virginia, Ctr Global Hlth, Charlottesville, VA 22904 USA. RP Learmonth, G (reprint author), Univ Virginia, POB 400747,151 Engn Way, Charlottesville, VA 22904 USA. EM jeffrey.demarest@usma.edu; spagsuyoin@uwaterloo.ca; jl5c@virginia.edu; jem3w@virginia.edu; rd8v@virginia.edu NR 41 TC 3 Z9 3 U1 0 U2 6 PU J A S S S PI GUILDFORD PA UNIV SURREY, DEPT SOCIOLOGY, GUILDFORD GU2 7XH, SURREY, ENGLAND SN 1460-7425 J9 JASSS-J ARTIF SOC S JI JASSS PD OCT PY 2013 VL 16 IS 4 AR 3 PG 14 WC Social Sciences, Interdisciplinary SC Social Sciences - Other Topics GA 295OF UT WOS:000330124700003 ER PT J AU Swearingen, ME White, MJ Ketcham, SA McKenna, MH AF Swearingen, Michelle E. White, Michael J. Ketcham, Stephen A. McKenna, Mihan H. TI Use of a porous material description of forests in infrasonic propagation algorithms SO JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA LA English DT Article ID SOUND-ATTENUATION; IMPEDANCE; MODELS; MEDIA AB Infrasound can propagate very long distances and remain at measurable levels. As a result infrasound sensing is used for remote monitoring in many applications. At local ranges, on the order of 10 km, the influence of the presence or absence of forests on the propagation of infrasonic signals is considered. Because the wavelengths of interest are much larger than the scale of individual components, the forest is modeled as a porous material. This approximation is developed starting with the relaxation model of porous materials. This representation is then incorporated into a Crank-Nicholson method parabolic equation solver to determine the relative impacts of the physical parameters of a forest (trunk size and basal area), the presence of gaps/trees in otherwise continuous forest/open terrain, and the effects of meteorology coupled with the porous layer. Finally, the simulations are compared to experimental data from a 10.9 kg blast propagated 14.5 km. Comparison to the experimental data shows that appropriate inclusion of a forest layer along the propagation path provides a closer fit to the data than solely changing the ground type across the frequency range from 1 to 30 Hz. C1 [Swearingen, Michelle E.; White, Michael J.] US Army Engineer Res & Dev Ctr, Construct Engn Res Lab, Champaign, IL 61826 USA. [Ketcham, Stephen A.] US Army Engineer Res & Dev Ctr, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. [McKenna, Mihan H.] US Army Engineer Res & Dev Ctr, Geotech & Struct Lab, Vicksburg, MS 39180 USA. RP Swearingen, ME (reprint author), US Army Engineer Res & Dev Ctr, Construct Engn Res Lab, Champaign, IL 61826 USA. EM michelle.e.swearingen@usace.army.mil FU U.S. Army Engineer Research and Development Center FX This work was supported by the U.S. Army Engineer Research and Development Center. The authors would like to thank Mr. Paul Graham and Mr. Robert H. Preseley for their test support at the Big Black Test Site. (Distribution Statement A-Approved for Public Release; distribution unlimited.) NR 22 TC 2 Z9 2 U1 0 U2 4 PU ACOUSTICAL SOC AMER AMER INST PHYSICS PI MELVILLE PA STE 1 NO 1, 2 HUNTINGTON QUADRANGLE, MELVILLE, NY 11747-4502 USA SN 0001-4966 EI 1520-8524 J9 J ACOUST SOC AM JI J. Acoust. Soc. Am. PD OCT PY 2013 VL 134 IS 4 BP 2647 EP 2659 DI 10.1121/1.4818742 PG 13 WC Acoustics; Audiology & Speech-Language Pathology SC Acoustics; Audiology & Speech-Language Pathology GA 295MH UT WOS:000330119700021 PM 24116403 ER PT J AU Costley, RD Frazier, WG Dillion, K Picucci, JR Williams, JE McKenna, MH AF Costley, R. Daniel Frazier, W. Garth Dillion, Kevin Picucci, Jennifer R. Williams, Jay E. McKenna, Mihan H. TI Frequency-wavenumber processing for infrasound distributed arrays SO JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA LA English DT Article ID WIND NOISE AB The work described herein discusses the application of a frequency-wavenumber signal processing technique to signals from rectangular infrasound arrays for detection and estimation of the direction of travel of infrasound. Arrays of 100 sensors were arranged in square configurations with sensor spacing of 2 m. Wind noise data were collected at one site. Synthetic infrasound signals were superposed on top of the wind noise to determine the accuracy and sensitivity of the technique with respect to signal-to-noise ratio. The technique was then applied to an impulsive event recorded at a different site. Preliminary results demonstrated the feasibility of this approach. C1 [Costley, R. Daniel; Picucci, Jennifer R.; McKenna, Mihan H.] US Army Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. [Frazier, W. Garth] Univ Mississippi, Natl Ctr Phys Acoust, University, MS 39677 USA. [Dillion, Kevin; Williams, Jay E.] Miltec Res & Technol, Oxford, MS 38655 USA. RP Costley, RD (reprint author), US Army Engineer Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM dan.costley@usace.army.mil; frazier@olemiss.edu; KDillion@one.ducommun.com; jennifer.r.picucci@usace.army.mil; JWilliams@one.ducommun.com; mihan.h.mckenna@usace.army.mil FU U.S. Army Space and Missile Defense Command; U.S. Army Engineer Research and Development Center FX The U.S. Army Space and Missile Defense Command supported the data collection and the initial array processing work. The U.S. Army Engineer Research and Development Center supported recent work. Permission to publish was granted by Director, Geotechnical and Structures Laboratory. NR 12 TC 1 Z9 1 U1 1 U2 4 PU ACOUSTICAL SOC AMER AMER INST PHYSICS PI MELVILLE PA STE 1 NO 1, 2 HUNTINGTON QUADRANGLE, MELVILLE, NY 11747-4502 USA SN 0001-4966 EI 1520-8524 J9 J ACOUST SOC AM JI J. Acoust. Soc. Am. PD OCT PY 2013 VL 134 IS 4 BP EL307 EP EL313 DI 10.1121/1.4818940 PG 7 WC Acoustics; Audiology & Speech-Language Pathology SC Acoustics; Audiology & Speech-Language Pathology GA 295MH UT WOS:000330119700004 PM 24116535 ER PT J AU Cafasso, DE Bowen, DK Kinkennon, SA Stanbro, MD Kellicut, DC AF Cafasso, D. E. Bowen, D. K. Kinkennon, S. A. Stanbro, M. D. Kellicut, D. C. TI Heterotopic ossificans in chronic venous insufficiency: a new consideration for clinical, aetiology, anatomy and pathophysiology staging SO PHLEBOLOGY LA English DT Article DE venous insufficiency; venous reflux; heterotopic ossification; wound care ID LEGS AB Objectives: Heterotopic ossification is defined as the abnormal formation of true bone within extra-skeletal soft tissues. It may be associated with a variety of clinical conditions, but is most frequently seen with musculoskeletal trauma, neurologic injury or genetic abnormalities. It has also been described in patients with chronic venous insufficiency; however, it often goes underdiagnosed due to chronic ulceration that masks exam findings. To date, few reports of heterotopic ossification due to chronic venous disease exist within the literature with the most recent dating back to the 1970s. Methods: We present a case study of a man presenting with extensive leg ulceration and a history of chronic venous insufficency. He had a large non-healing venous stasis ulcer of the left lower extremity with extensive heterotopic ossification discovered intraoperatively. Results: The patient was managed with serial wound debridement, innovative woundcare and eventual split thickness skin grafting that achieved limb salvage despite the complexity of his wound. Conclusions: Our discussion focuses on the epidemiology, pathophysiology, diagnostic work-up and management of heterotopic ossification in the setting of chronic venous insufficiency. We propose that heterotopic ossification be included in any future modifications of the clinical, aetiology, anatomy and pathophysiology system classification as a complication of chronic venous disease. C1 [Cafasso, D. E.; Bowen, D. K.; Kinkennon, S. A.; Kellicut, D. C.] Tripler Army Med Ctr, Dept Surg, Honolulu, HI 96859 USA. [Stanbro, M. D.] Greenville Hosp Syst, Vein Ctr, Vasc Hlth Alliance, Greenville, SC 29615 USA. RP Cafasso, DE (reprint author), Tripler Army Med Ctr, Dept Surg, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM danielle.cafasso@us.army.mil NR 8 TC 0 Z9 0 U1 1 U2 1 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0268-3555 EI 1758-1125 J9 PHLEBOLOGY JI Phlebology PD OCT PY 2013 VL 28 IS 7 BP 361 EP 365 DI 10.1258/phleb.2012.012050 PG 5 WC Surgery; Peripheral Vascular Disease SC Surgery; Cardiovascular System & Cardiology GA 298BK UT WOS:000330298700004 PM 23202142 ER PT J AU Daddis, GA AF Daddis, Gregory A. TI Out of Balance: Evaluating American Strategy in Vietnam, 1968-72 SO WAR & SOCIETY LA English DT Article DE Vietnam War; Nixon; Vietnamization; Republic of Vietnam AB This paper examines the ineffective implementation of American military strategy in the Vietnam War's final years. While the Nixon administration conceived a comprehensive strategic concept aimed at winding down the war in South Vietnam, civilian and military leaders struggled to realize, in an effectual manner, Nixon's wide-ranging political objectives. American officials in Saigon and Washington found it near impossible to balance the competing strategic imperatives of combat operations, diplomatic negotiations, Vietnamization, and the withdrawal of US forces from South-east Asia. This inability to reconcile imbalances within the American strategic framework helps explain more fully the outcome of US political and military efforts in South Vietnam. C1 US Mil Acad, West Point, NY 10996 USA. RP Daddis, GA (reprint author), US Mil Acad, West Point, NY 10996 USA. EM Gregory.Daddis@usma.edu NR 114 TC 0 Z9 0 U1 0 U2 3 PU MANEY PUBLISHING PI LEEDS PA STE 1C, JOSEPHS WELL, HANOVER WALK, LEEDS LS3 1AB, W YORKS, ENGLAND SN 0729-2473 EI 2042-4345 J9 WAR SOC JI War Soc. PD OCT PY 2013 VL 32 IS 3 BP 252 EP 270 DI 10.1179/0729247313Z.00000000026 PG 19 WC History SC History GA 296FQ UT WOS:000330171000004 ER PT J AU Kennedy, AJ Melby, NL Moser, RD Bednar, AJ Son, SF Lounds, CD Laird, JG Nellums, RR Johnson, DR Steevens, JA AF Kennedy, Alan J. Melby, Nicolas L. Moser, Robert D. Bednar, Anthony J. Son, Steven F. Lounds, Christopher D. Laird, Jennifer G. Nellums, Robert R. Johnson, David R. Steevens, Jeffery A. TI Fate and Toxicity of CuO Nanospheres and Nanorods used in Al/CuO Nanothermites Before and After Combustion SO ENVIRONMENTAL SCIENCE & TECHNOLOGY LA English DT Article ID COPPER-OXIDE NANOPARTICLES; ION-RELEASE KINETICS; SILVER NANOPARTICLES; DAPHNIA-MAGNA; CERIODAPHNIA-DUBIA; FRESH-WATER; AQUATIC TOXICITY; ALUMINUM-OXIDE; NANOMATERIALS; ORGANISMS AB Although nanotechnology advancements should be fostered, the environmental health and safety (EHS) of nanoparticles used in technologies must be quantified simultaneously. However, most EHS studies assess the potential implications of the free nanoparticles which may. not be directly applicable to the EHS of particles incorporated into in-use technologies. This investigation assessed the aquatic toxicological implications of copper oxide (CuO) nanospheres relative to CuO nanorods used in nanoenergetic applications to improve combustion. Particles were tested in both the as-received form and following combustion of a CuO/aluminum nanothermite. Results indicated nanospheres were more stable in water and slowly released ions, while higher surface area nanorods initially released more ions and were more toxic but generally less stable. After combustion, particles sintered into larger, micrometer-scale aggregates, which may lower toxicity potential to pelagic organisms due to deposition from water to sediment and reduced bioavailability after complexation with sediment organic matter. Whereas the larger nanothermite residues settled rapidly, implying lower persistence in water, their potential to release dissolved Cu was higher which led to greater toxicity to Ceriodaphnia dubia relative to parent CuO material (nanosphere or rod). This study illustrates the importance of considering the fate and toxicology of nanoparticles in context with their relevant in-use applications. C1 [Kennedy, Alan J.; Moser, Robert D.; Bednar, Anthony J.; Laird, Jennifer G.; Johnson, David R.; Steevens, Jeffery A.] US Army, Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA. [Melby, Nicolas L.; Lounds, Christopher D.] Badger Tech Serv, Vicksburg, MS 39180 USA. [Son, Steven F.; Nellums, Robert R.] Purdue Univ, Sch Mech Engn, W Lafayette, IN 47907 USA. RP Kennedy, AJ (reprint author), US Army, Engineer Res & Dev Ctr, Environm Lab, Bldg 3270,EP R,3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM Alan.J.Kennedy@usace.army.mil OI Son, Steven/0000-0001-7498-2922 FU U.S. Army Environmental Quality Technology Research Program FX This research was funded by the U.S. Army Environmental Quality Technology Research Program (Dr. Elizabeth Ferguson, technical director). Permission was granted by the Chief of Engineers to publish this information. The use of trade, product, or firm names in this report is for descriptive purposes only and does not imply endorsement by the U.S. Government. The findings of this report are not to be construed as an official Department of the Army position unless so designated by other authorized documents. We thank 3 anonymous reviewers for constructive comments. NR 57 TC 6 Z9 6 U1 6 U2 34 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0013-936X EI 1520-5851 J9 ENVIRON SCI TECHNOL JI Environ. Sci. Technol. PD OCT 1 PY 2013 VL 47 IS 19 BP 11258 EP 11267 DI 10.1021/es401837f PG 10 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA 295CT UT WOS:000330094900064 PM 23971725 ER PT J AU Ong, BA Caboot, J Jawad, A McDonough, J Jackson, T Arens, R Marcus, CL Smith-Whitley, K Mason, TBA Ohene-Frempong, K Allen, JL AF Ong, Bruce A. Caboot, Jason Jawad, Abbas McDonough, Joseph Jackson, Tannoa Arens, Raanan Marcus, Carole L. Smith-Whitley, Kim Mason, Thornton B. A. Ohene-Frempong, Kwaku Allen, Julian L. TI Respiratory muscle force and lung volume changes in a population of children with sickle cell disease SO BRITISH JOURNAL OF HAEMATOLOGY LA English DT Article DE paediatrics; muscle strength; pulmonary function; sickle cell anaemia ID NORMAL VALUES; BLOOD-FLOW; PULMONARY COMPLICATIONS; HEALTHY-CHILDREN; STATIC PRESSURES; FUNCTION TESTS; STANDARDIZATION; VENTILATION; STRENGTH; GROWTH AB Sickle cell disease (SCD) is a disorder known to impact the respiratory system. We sought to identify respiratory muscle force and lung volume relationships in a paediatric SCD population. Thirty-four SCD-SS subjects underwent pulmonary function testing. Height, weight, age, and gender-adjusted percent predicted maximal inspiratory pressure (MIP) and maximal expiratory pressure (MEP) values were compared to spirometry and lung volumes. Statistical analyses were performed using Pearson's correlation coefficient and paired two-tailed t-test. The mean +/- standard deviation (SD) MIP and MEP was 69 center dot 6 +/- 31 center dot 6cm H2O and 66 center dot 9 +/- 22 center dot 9cm H2O, respectively, and mean +/- SD percent predicted MIP (101 center dot 3 +/- 45 center dot 9) exceeded MEP (72 center dot 1 +/- 26 center dot 0) (P=0 center dot 002). MIP correlated with forced vital capacity (FVC; r=0 center dot 51, P=0 center dot 001) and TLC (r=0 center dot 54, P<0 center dot 0001). MEP also correlated with FVC (r=0 center dot 43, P=0 center dot 011) and total lung capacity (TLC; r=0 center dot 42, P=0 center dot 013). Pearson's correlation coefficient testing yielded relationships between MIP and MEP (r=0 center dot 64, P<0 center dot 0001). SCD-SS patients showed correlations between respiratory muscle force and lung volume, and reduced percent predicted expiratory muscle force compared to inspiratory muscle force. Respiratory muscle strength may affect lung volumes in these patients, and expiratory muscles may be more susceptible than the diaphragm to SCD-induced vaso-occlusive damage. C1 [Ong, Bruce A.] Tripler Army Med Ctr, Div Pediat Pulmonol, Honolulu, HI 96859 USA. [Caboot, Jason] Madigan Army Med Ctr, Div Pediat Pulmonol, Ft Lewis, WA USA. [Jawad, Abbas] Childrens Hosp Philadelphia, Div Biostat, Philadelphia, PA 19104 USA. [McDonough, Joseph; Marcus, Carole L.; Allen, Julian L.] Childrens Hosp Philadelphia, Div Pulm Med, Philadelphia, PA 19104 USA. [Jackson, Tannoa; Smith-Whitley, Kim; Ohene-Frempong, Kwaku] Childrens Hosp Philadelphia, Div Hematol, Philadelphia, PA 19104 USA. [Arens, Raanan] Childrens Hosp Montefiore, Div Resp & Sleep Med, Bronx, NY USA. [Mason, Thornton B. A.] Childrens Hosp Philadelphia, Div Neurol, Philadelphia, PA 19104 USA. RP Allen, JL (reprint author), Childrens Hosp Philadelphia, Div Pulm Med, 34th & Civ Ctr Blvd, Philadelphia, PA 19104 USA. EM allenj@email.chop.edu FU National Heart, Lung, and Blood Institute (NHLBI) [5R01HL079911-04]; National Institutes of Health Clinical and Translational Science Award [NCATS UL1 TR000003] FX This study was supported by National Heart, Lung, and Blood Institute (NHLBI) grant 5R01HL079911-04: Oxyhemoglobin Desaturation and Vasculopathy in Sickle Cell Disease and by an National Institutes of Health Clinical and Translational Science Award: NCATS UL1 TR000003. NR 31 TC 4 Z9 5 U1 0 U2 4 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0007-1048 EI 1365-2141 J9 BRIT J HAEMATOL JI Br. J. Haematol. PD OCT PY 2013 VL 163 IS 1 BP 112 EP 117 DI 10.1111/bjh.12481 PG 6 WC Hematology SC Hematology GA 216YQ UT WOS:000324323300014 PM 23869561 ER PT J AU Jones, BM Stoker, JM Gibbs, AE Grosse, G Romanovsky, VE Douglas, TA Kinsman, NEM Richmond, BM AF Jones, Benjamin M. Stoker, Jason M. Gibbs, Ann E. Grosse, Guido Romanovsky, Vladimir E. Douglas, Thomas A. Kinsman, Nicole E. M. Richmond, Bruce M. TI Quantifying landscape change in an arctic coastal lowland using repeat airborne LiDAR SO ENVIRONMENTAL RESEARCH LETTERS LA English DT Article DE Arctic; coasts; LiDAR; permafrost; thermokarst ID INTERNATIONAL POLAR YEAR; BEAUFORT SEA COAST; HERSCHEL ISLAND; YUKON-TERRITORY; NORTH-CAROLINA; THERMAL STATE; ACTIVE-LAYER; PERMAFROST; EROSION; ALASKA AB Increases in air, permafrost, and sea surface temperature, loss of sea ice, the potential for increased wave energy, and higher river discharge may all be interacting to escalate erosion of arctic coastal lowland landscapes. Here we use airborne light detection and ranging (LiDAR) data acquired in 2006 and 2010 to detect landscape change in a 100 km(2) study area on the Beaufort Sea coastal plain of northern Alaska. We detected statistically significant change (99% confidence interval), defined as contiguous areas (>10 m(2)) that had changed in height by at least 0.55 m, in 0.3% of the study region. Erosional features indicative of ice-rich permafrost degradation were associated with ice-bonded coastal, river, and lake bluffs, frost mounds, ice wedges, and thermo-erosional gullies. These features accounted for about half of the area where vertical change was detected. Inferred thermo-denudation and thermo-abrasion of coastal and river bluffs likely accounted for the dominant permafrost-related degradational processes with respect to area (42%) and volume (51%). More than 300 thermokarst pits significantly subsided during the study period, likely as a result of storm surge flooding of low-lying tundra (<1.4 m asl) as well as the lasting impact of warm summers in the late-1980s and mid-1990s. Our results indicate that repeat airborne LiDAR can be used to detect landscape change in arctic coastal lowland regions at large spatial scales over sub-decadal time periods. C1 [Jones, Benjamin M.] US Geol Survey, Alaska Sci Ctr, Anchorage, AK 99508 USA. [Stoker, Jason M.] US Geol Survey, Earth Resource & Observat Sci Ctr, Sioux Falls, SD 57198 USA. [Gibbs, Ann E.; Richmond, Bruce M.] US Geol Survey, Pacific Coastal & Marine Sci Ctr, Santa Cruz, CA 95060 USA. [Grosse, Guido; Romanovsky, Vladimir E.] Univ Alaska Fairbanks, Inst Geophys, Fairbanks, AK 99775 USA. [Douglas, Thomas A.] US Army, Cold Reg Res & Engn Lab, Ft Wainwright, AK 99703 USA. [Kinsman, Nicole E. M.] Alaska Div Geol & Geophys Surveys, Fairbanks, AK 99708 USA. RP Jones, BM (reprint author), US Geol Survey, Alaska Sci Ctr, Anchorage, AK 99508 USA. EM bjones@usgs.gov RI Grosse, Guido/F-5018-2011; OI Grosse, Guido/0000-0001-5895-2141; Stoker, Jason/0000-0003-2455-0931 FU US Geological Survey-Alaska Regional Directors Office, Alaska Science Center; Earth Resource and Observation Science Center; National Geospatial Program; Coastal and Marine Geology Program; Arctic Landscape Conservation Cooperative; NASA [NNX08AJ37G]; Strategic Environmental Research and Development Program (SERDP) Project [RC-2110] FX Funding for this research was primarily provided by the US Geological Survey-Alaska Regional Directors Office, Alaska Science Center, the Earth Resource and Observation Science Center, the National Geospatial Program, and the Coastal and Marine Geology Program. Additional support was provided by the Arctic Landscape Conservation Cooperative and GG was supported by NASA grant #NNX08AJ37G. TAD was supported by funding from the Strategic Environmental Research and Development Program (SERDP) Project RC-2110. We kindly thank Stephan Gruber, Carl Markon, and an anonymous reviewer for their thoughtful and thorough critique of this letter. Any use of trade, product, or firm names is for descriptive purposes only and does not imply endorsement by the US Government. NR 42 TC 12 Z9 12 U1 2 U2 32 PU IOP PUBLISHING LTD PI BRISTOL PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND SN 1748-9326 J9 ENVIRON RES LETT JI Environ. Res. Lett. PD OCT-DEC PY 2013 VL 8 IS 4 AR 045025 DI 10.1088/1748-9326/8/4/045025 PG 10 WC Environmental Sciences; Meteorology & Atmospheric Sciences SC Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences GA 288IJ UT WOS:000329604900089 ER PT J AU Hammond, RT AF Hammond, Richard T. TI SPIN FROM THE NONSYMMETRIC METRIC TENSOR SO INTERNATIONAL JOURNAL OF MODERN PHYSICS D LA English DT Article DE Nonsymmetric metric; torsion; spin ID TORSION; GRAVITY AB A solution to the gravitational field equations based on a nonsymmetric metric tensor is examined. Unlike Einstein's interpretation of electromagnetism, or Moffat's generalized gravity, it is shown that the nonsymmetric part of the metric tensor is the potential of the spin field, and its intimate connection to string theory is established. This formulation solves the longstanding problem of electromagnetism and torsion, naturally showing how electromagnetism, through its intrinsic spin, can create torsion. C1 [Hammond, Richard T.] Univ N Carolina, Dept Phys, Chapel Hill, NC 27515 USA. [Hammond, Richard T.] Army Res Off, Res Triangle Pk, NC USA. RP Hammond, RT (reprint author), Univ N Carolina, Dept Phys, Chapel Hill, NC 27515 USA. EM rhammond@email.unc.edu NR 13 TC 0 Z9 0 U1 0 U2 4 PU WORLD SCIENTIFIC PUBL CO PTE LTD PI SINGAPORE PA 5 TOH TUCK LINK, SINGAPORE 596224, SINGAPORE SN 0218-2718 EI 1793-6594 J9 INT J MOD PHYS D JI Int. J. Mod. Phys. D PD OCT PY 2013 VL 22 IS 12 SI SI AR 1342009 DI 10.1142/S0218271813420091 PG 7 WC Astronomy & Astrophysics SC Astronomy & Astrophysics GA 280RQ UT WOS:000329048900016 ER PT J AU Kelly, JW Burton, M Pollock, B Rubio, E Curtis, M De la Cruz, J Gilbert, S Winer, E AF Kelly, Jonathan W. Burton, Melissa Pollock, Brice Rubio, Eduardo Curtis, Michael De la Cruz, Julio Gilbert, Stephen Winer, Eliot TI Space Perception in Virtual Environments: Displacement from the Center of Projection Causes Less Distortion than Predicted by Cue-Based Models SO ACM TRANSACTIONS ON APPLIED PERCEPTION LA English DT Article DE Experimentation; Human Factors; Depth perception; stereoscopic displays; virtual environments ID RETINAL OPTIC FLOW; DISTANCE PERCEPTION; DEPTH-PERCEPTION; SPATIAL LAYOUT; VISUAL SPACE; PICTURES; REALITY; VIEW; SIZE; INFORMATION AB Virtual reality systems commonly include both monocular and binocular depth cues, which have the potential to provide viewers with a realistic impression of spatial properties of the virtual environment. However, when multiple viewers share the same display, only one viewer typically receives the projectively correct images. All other viewers experience the same images despite displacement from the center of projection (CoP). Three experiments evaluated perceptual distortions caused by displacement from the CoP and compared those percepts to predictions of models based on monocular and binocular viewing geometry. Leftward and rightward displacement from the CoP caused virtual angles on the ground plane to be judged as larger and smaller, respectively, compared to judgments from the CoP. Backward and forward displacement caused rectangles on the ground plane to be judged as larger and smaller in depth, respectively, compared to judgments from the CoP. Judgment biases were in the same direction as cue-based model predictions but of smaller magnitude. Displacement from the CoP had asymmetric effects on perceptual judgments, unlike model predictions. Perceptual distortion occurred with monocular cues alone but was exaggerated when binocular cues were added. The results are grounded in terms of practical implications for multiuser virtual environments. C1 [Kelly, Jonathan W.; Burton, Melissa; Pollock, Brice; Rubio, Eduardo; Curtis, Michael; Gilbert, Stephen; Winer, Eliot] Iowa State Univ, Ames, IA USA. [De la Cruz, Julio] US Army Res Lab, Human Res & Engn Directorate, Simulat & Training Technol Ctr, Adelphi, MD USA. RP Kelly, JW (reprint author), Iowa State Univ, Iowa State Univ Psychol, W112 Lagomarcino Hall, Ames, IA 50011 USA. EM jonkelly@iastate.edu RI Kelly, Jonathan/A-4793-2013 FU United States Army Research Laboratory's Human Research and Engineering Directorate, Simulation and Training Technology Center FX This work was supported by a grant from the United States Army Research Laboratory's Human Research and Engineering Directorate, Simulation and Training Technology Center. Results from Experiment 1 were presented at the 2012 meeting of the SPIE. NR 50 TC 3 Z9 3 U1 1 U2 6 PU ASSOC COMPUTING MACHINERY PI NEW YORK PA 2 PENN PLAZA, STE 701, NEW YORK, NY 10121-0701 USA SN 1544-3558 EI 1544-3965 J9 ACM T APPL PERCEPT JI ACM Trans. Appl. Percept. PD OCT PY 2013 VL 10 IS 4 AR 18 DI 10.1145/2536764.2536765 PG 23 WC Computer Science, Software Engineering SC Computer Science GA 281YK UT WOS:000329136700001 ER PT J AU Coletti, F Benson, MJ Ling, J Elkins, CJ Eaton, JK AF Coletti, F. Benson, M. J. Ling, J. Elkins, C. J. Eaton, J. K. TI Turbulent transport in an inclined jet in crossflow SO INTERNATIONAL JOURNAL OF HEAT AND FLUID FLOW LA English DT Article; Proceedings Paper CT 7th International Symposium on Turbulence Heat and Mass Transfer (THMT) CY SEP 24-27, 2012 CL Palermo, ITALY DE Jet in crossflow; Film cooling; Turbulent mixing; Turbulent diffusivity ID DIRECT NUMERICAL-SIMULATION; FILM-COOLING FLOWS; TRANSVERSE JETS; PRANDTL NUMBER; ENTRAINMENT; PREDICTIONS; EVOLUTION; MODEL AB The present study experimentally investigates a turbulent jet in crossflow relevant to film cooling applications. The jet is inclined at 30 degrees, and its mean velocity is the same as the crossflow. Magnetic resonance imaging is used to obtain the full three-dimensional velocity and concentration fields, whereas Reynolds stresses are obtained along selected planes by Particle Image Velocimetry. The critical role of the counter-rotating vortex pair in the mixing process is apparent from both velocity and concentration fields. The jet entrainment is not significantly higher than in an axisymmetric jet without crossflow, because the proximity of the wall inhibits the turbulent transport. Reynolds shear stresses correlate with velocity and concentration gradients, consistent with the fundamental assumptions of simple turbulence models. However the eddy viscosity is strongly anisotropic and non-homogeneous, being especially low along the leeward side of the jet close to injection. Turbulent diffusion acts to decouple mean velocity and concentration fields, as demonstrated by the drop in concentration flux within the streamtube issued from the hole. Volume-averaged turbulent diffusivity is calculated using a mass-flux balance across the streamtube emanating from the jet hole, and it is found to vary slowly in the streamwise direction. The data are compared with Reynolds-Averaged Navier-Stokes simulations with standard k - epsilon closure and an optimal turbulent Schmidt number. The computations underestimate the strength of the counter-rotating vortex pair, due to an overestimated eddy viscosity. On the other hand the entrainment is increasingly underpredicted downstream of injection. To capture the correct macroscopic trends, eddy viscosity and eddy diffusivity should vary spatially in different ways. Therefore a constant turbulent Schmidt number formulation is inadequate for this flow. (C) 2013 Elsevier Inc. All rights reserved. C1 [Coletti, F.; Ling, J.; Elkins, C. J.; Eaton, J. K.] Stanford Univ, Dept Mech Engn, Stanford, CA 94305 USA. [Benson, M. J.] US Mil Acad, Dept Civil & Mech Engn, West Point, NY 10996 USA. RP Coletti, F (reprint author), Stanford Univ, Dept Mech Engn, Stanford, CA 94305 USA. EM colettif@stanford.edu; michael.benson@usma.edu; julial@stanford.edu; celkins@stanford.edu; eatonj@stanford.edu NR 36 TC 16 Z9 16 U1 1 U2 29 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0142-727X EI 1879-2278 J9 INT J HEAT FLUID FL JI Int. J. Heat Fluid Flow PD OCT PY 2013 VL 43 BP 149 EP 160 DI 10.1016/j.ijheatfluidflow.2013.06.001 PG 12 WC Thermodynamics; Engineering, Mechanical; Mechanics SC Thermodynamics; Engineering; Mechanics GA 275EV UT WOS:000328660000015 ER PT J AU Johnson, GE Khan, F Skalski, JR Klatte, BA AF Johnson, Gary E. Khan, Fenton Skalski, John R. Klatte, Bernard A. TI Sluiceway Operations to Pass Juvenile Salmonids at The Dalles Dam, Columbia River, USA SO NORTH AMERICAN JOURNAL OF FISHERIES MANAGEMENT LA English DT Article ID HYDROPOWER DAMS; WELLS DAM; FISH; BYPASS; WASHINGTON; GATEWELLS; BEHAVIOR AB Existing ice and trash sluiceways are commonly used as benign, nonturbine routes for downstream passage of juvenile salmonids at hydropower dams. At The Dalles Dam on the Columbia River, we studied various operational configurations of sluiceway weirs to maximize sluiceway passage of juvenile Pacific salmon Oncorhynchus spp. and steelhead O. mykiss. We applied hydroacoustic methods to compare fish passage rates and sluiceway efficiencies for two weir configurations in each year: three weirs (SL 1; i.e., collectively referring to the three weirs above main turbine unit [MU] 1) versus six weirs (SL 1+18) during 2004; and middle (SL 2+5) versus east (SL 2+19) powerhouse weir locations during 2005. Horizontal distributions at the sluiceway and turbines and the effects of operating turbines beneath open sluiceway gates were also analyzed. Sluiceway passage efficiency relative to the powerhouse (SLY (phs) ) varied between study years, between spring and summer, and between day and night. In 2004, sluiceway passage rates were significantly higher (P = 0.0003) for SL 1+18 than for SL 1 during summer-night but were not significantly different between the two configurations during the other three season-day/night periods. The SLY (phs) was significantly higher for SL 1+18 than for SL 1. The location comparison during 2005 revealed no significant differences between the SL 2+5 and SL 2+19 configurations, except for summer-day. The experimental findings led to recommendations for long-term operations of The Dalles Dam sluiceway: open six rather than three sluiceway weirs to take advantage of the maximum hydraulic capacity of the sluiceway; open the three weirs above the westernmost operating MU and the three weirs at SL 8, where turbine passage rates are relatively high; operate the MUs below open sluiceway weirs as a standard procedure; operate the sluiceway 24h/d year-round to maximize its benefits to juvenile salmonids; and use the same weir configuration year-round. These operational concepts are transferable to dams where sluiceway surface flow outlets are used to protect downstream-migrating fishes. Received July 19, 2012; accepted June 26, 2013 C1 [Johnson, Gary E.; Khan, Fenton] Pacific NW Natl Lab, Richland, WA 99352 USA. [Skalski, John R.] Univ Washington, Seattle, WA 98101 USA. [Klatte, Bernard A.] US Army Corps Engineers, Portland, OR 97208 USA. RP Johnson, GE (reprint author), Pacific NW Natl Lab, POB 999 K6-85, Richland, WA 99352 USA. EM gary.johnson@pnnl.gov OI Skalski, John/0000-0002-7070-2505 FU USACE; U.S. Department of Energy [DE-AC05-76RL01830] FX This research was funded by USACE through the Anadromous Fish Evaluation Program, Columbia River Fish Mitigation Project. We sincerely appreciate contributions by Bob Cordie, Mike Langeslay, Steve Schlenker, and Miro Zyndol (USACE); Alan Wirtz (PAS); Susan Ennor, Eric Fischer, David Geist, James Hughes, Megan Peters, Gene Ploskey, Cindy Rakowski, Marshall Richmond, Ida Royer, John Serkowski, and Chris Vernon (PNNL); and three peer reviewers. Pacific Northwest National Laboratory is operated by Battelle for the U.S. Department of Energy under Contract Number DE-AC05-76RL01830. Reference to trade names does not imply endorsement by the U.S. Government. NR 55 TC 1 Z9 1 U1 2 U2 13 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA SN 0275-5947 EI 1548-8675 J9 N AM J FISH MANAGE JI North Am. J. Fish Manage. PD OCT 1 PY 2013 VL 33 IS 5 BP 1000 EP 1012 DI 10.1080/02755947.2013.822441 PG 13 WC Fisheries SC Fisheries GA 264HP UT WOS:000327867900016 ER PT J AU Khan, F Royer, IM Johnson, GE Tackley, SC AF Khan, Fenton Royer, Ida M. Johnson, Gary E. Tackley, Sean C. TI Sluiceway Operations for Adult Steelhead Downstream Passage at The Dalles Dam, Columbia River, USA SO NORTH AMERICAN JOURNAL OF FISHERIES MANAGEMENT LA English DT Article ID SALMO-SALAR SMOLTS; SNAKE RIVER; JUVENILE SALMONIDS; ATLANTIC SALMON; BONNEVILLE DAM; BYPASS SYSTEM; HYDROELECTRIC DAMS; HYDROPOWER DAMS; CHINOOK SALMON; WELLS DAM AB Sluiceways at hydroelectric dams are designed to enable floating ice and debris to pass through the dams and may be used as an effective, nonturbine, surface route for out-migrating fishes to pass through dams. Each year, the sluiceway at The Dalles Dam on the Columbia River, USA, is normally operated between 1 April and 30 November and the spillway between 10 April and 31 August to enable downstream-migrating juvenile Pacific salmonids to pass. The only route available for fishes to pass the dam between 1 December and 31 March is through the turbines. This study evaluated downstream passage of adult steelhead Oncorhynchus mykiss at The Dalles Dam during various periods between 1 November and 10 April for years 2008 through 2010. The purpose of the study was to determine the efficacy of operating the sluiceway between 1 December and 31 March to provide a relatively safe, nonturbine, surface outlet for downstream passage of adult steelhead that overwinter in the lower Columbia River (i.e., fallbacks) or for adult steelhead attempting to emigrate back to the marine environment after spawning (i.e., kelts). We applied a fixed-location hydroacoustic technique to estimate downstream passage rates at the sluiceway and turbines. The sluiceway was used by 91-99% of the adult steelhead during all sampling periods; the remaining 1-9% passed through the turbines. This implies that adult steelhead preferred the sluiceway for downstream passage at the dam. Our results indicate that keeping the sluiceway open between 1 December and 31 March may provide an optimal, nonturbine surface route for downstream passage of overwintering or postspawned adult steelhead at The Dalles Dam. Similar operations are relevant at hydroelectric dams with surface-flow outlets, such as sluiceways, for safe downstream passage of fish species of management concern. Received July 19, 2012; accepted March 27, 2013 C1 [Khan, Fenton; Royer, Ida M.; Johnson, Gary E.] Pacific NW Natl Lab, Richland, WA 99352 USA. [Khan, Fenton; Tackley, Sean C.] US Army Corps Engineers, Portland, OR 97208 USA. RP Khan, F (reprint author), US Army Corps Engineers, POB 2946, Portland, OR 97208 USA. EM fenton.o.khan@usace.army.mil FU U.S. Army Corps of Engineers, Portland District through the Anadromous Fish Evaluation Program; U.S. Department of Energy [DE-AC05-76RL01830] FX This research was funded by the U.S. Army Corps of Engineers, Portland District through the Anadromous Fish Evaluation Program. We sincerely appreciate support and contributions by David Clugston, Robert Cordie, Mike Langeslay, Natalie Richards, Steve Schlenker, Robert Wertheimer, and Miro Zyndol (U.S. Army Corps of Engineers); Alan Wirtz (Precision Acoustic Systems); Susan Ennor, Eric Fischer, David Geist, James Hughes, Megan Peters, Gene Ploskey, Chris Vernon, and Mark Weiland (Pacific Northwest National Laboratory), and three anonymous reviewers. Pacific Northwest National Laboratory is operated by Battelle for the U.S. Department of Energy under Contract DE-AC05-76RL01830. Reference to trade names does not imply endorsement by the U.S. Government. NR 50 TC 0 Z9 0 U1 2 U2 16 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA SN 0275-5947 EI 1548-8675 J9 N AM J FISH MANAGE JI North Am. J. Fish Manage. PD OCT 1 PY 2013 VL 33 IS 5 BP 1013 EP 1023 DI 10.1080/02755947.2013.793629 PG 11 WC Fisheries SC Fisheries GA 264HP UT WOS:000327867900017 ER PT J AU Wilkinson, I Cohen, SP AF Wilkinson, Indy Cohen, Steven P. TI Epidural steroids for spinal pain and radiculopathy: a narrative, evidence-based review SO CURRENT OPINION IN ANESTHESIOLOGY LA English DT Review DE back pain; epidural steroid; neck pain; radicular pain; radiculopathy; sciatica ID LOW-BACK-PAIN; LUMBAR RADICULAR PAIN; CONTRAST FLOW PATTERNS; LOWER-EXTREMITY PAIN; 2000-2010 TASK-FORCE; NECK PAIN; CERVICAL RADICULOPATHY; NEUROPATHIC PAIN; DISC HERNIATION; NERVE ROOT AB Purpose of reviewEpidural steroid injections (ESIs) are the most commonly performed intervention in pain clinics across the USA and worldwide. In light of the growing use of ESIs, a recent spate of highly publicized infectious complications, and increasing emphasis on cost-effectiveness, the utility of ESI has recently come under intense scrutiny. This article provides an evidence-based review of ESIs, including the most up-to-date information on patient selection, comparison of techniques, efficacy, and complications.Recent findingsThe data strongly suggest that ESIs can provide short-term relief of radicular symptoms but are less convincing for long-term relief, and mixed regarding cost-effectiveness. Although some assert that transforaminal ESIs are more efficacious than interlaminar ESIs, and that fluoroscopy can improve treatment outcomes, the evidence to support these assertions is limited.SummaryThe cost-effectiveness of ESI is the subject of great debate, and similar to efficacy, the conclusions one draws appear to be influenced by specialty. Because of the wide disparities regarding indications and utilization, it is likely that indiscriminate use is cost-ineffective, but that judicious use in well-selected patients can decrease healthcare utilization. More research is needed to better refine selection criteria for ESI, and to determine which approach, what dose, and how many injections are optimal. C1 [Wilkinson, Indy] Womack Army Med Ctr, Ft Bragg, NC USA. [Cohen, Steven P.] Johns Hopkins Sch Med, Dept Anesthesiol & Crit Care Med, Baltimore, MD USA. [Cohen, Steven P.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. RP Cohen, SP (reprint author), Johns Hopkins Pain Treatment Ctr, 550 N Broadway,Suite 301, Baltimore, MD 21205 USA. EM scohen40@jhmi.edu FU Center for Rehabilitation Sciences Research, Dept. of Physical Medicine and Rehabiliation, Uniformed Services University of the Health Sciences, Bethesda, MD FX This article was funded in part by the Center for Rehabilitation Sciences Research, Dept. of Physical Medicine and Rehabiliation, Uniformed Services University of the Health Sciences, Bethesda, MD. NR 117 TC 9 Z9 9 U1 0 U2 4 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0952-7907 EI 1473-6500 J9 CURR OPIN ANESTHESIO JI Curr. Opin. Anesthesiol. PD OCT PY 2013 VL 26 IS 5 BP 562 EP 572 DI 10.1097/ACO.0b013e3283628e87 PG 11 WC Anesthesiology SC Anesthesiology GA 264SF UT WOS:000327900100008 PM 23787490 ER PT J AU Wangchuk, S Chinnawirotpisan, P Dorji, T Tobgay, T Dorji, T Yoon, IK Fernandez, S AF Wangchuk, Sonam Chinnawirotpisan, Piyawan Dorji, Tshering Tobgay, Tashi Dorji, Tandin Yoon, In-Kyu Fernandez, Stefan TI Chikungunya Fever Outbreak, Bhutan, 2012 SO EMERGING INFECTIOUS DISEASES LA English DT Article ID VIRUSES; EPIDEMIC AB In 2012, chikungunya virus (CHIKV) was reported for the first time in Bhutan. IgM ELISA results were positive for 36/210 patient samples; FOR was positive for 32/81. Phylogenetic analyses confirmed that Bhutan CHIKV belongs to the East/Central/South African genotype. Appropriate responses to future outbreaks require a system of surveillance and improved laboratory capacity. C1 [Wangchuk, Sonam] Minist Hlth, Dept Publ Hlth, Publ Hlth Lab, Thimphu, Bhutan. [Dorji, Tshering; Tobgay, Tashi; Dorji, Tandin] Minist Hlth, Thimphu, Bhutan. [Chinnawirotpisan, Piyawan; Yoon, In-Kyu; Fernandez, Stefan] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. RP Fernandez, S (reprint author), Armed Forces Res Inst Med Sci, Dept Virol, 315-6 Rajvithi Rd, Bangkok 10400, Thailand. EM stefan.fernandez@afrims.org FU Armed Forces Health Surveillance Center Global Emerging Infections Surveillance and Response System FX This work was supported by the Armed Forces Health Surveillance Center Global Emerging Infections Surveillance and Response System. NR 13 TC 15 Z9 15 U1 0 U2 3 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 1080-6040 EI 1080-6059 J9 EMERG INFECT DIS JI Emerg. Infect. Dis PD OCT PY 2013 VL 19 IS 10 BP 1681 EP 1684 DI 10.3201/eid1910.130453 PG 4 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 268MC UT WOS:000328173900025 PM 24047543 ER PT J AU Shaw, AP Poret, JC Gilbert, RA Domanico, JA Black, EL AF Shaw, Anthony P. Poret, Jay C. Gilbert, Robert A., Jr. Domanico, Joseph A. Black, Ernest L. TI Development and Performance of Boron Carbide-Based Smoke Compositions SO PROPELLANTS EXPLOSIVES PYROTECHNICS LA English DT Article DE Pyrotechnics; Smoke; Boron carbide; Environmental AB Pyrotechnic smoke compositions for visual obscuration containing boron carbide, potassium nitrate, potassium chloride, and various lubricants are described. Only the waxy lubricants stearic acid and calcium stearate slowed the burning rate into a range suitable for end-burning smoke grenades. For compositions pressed into steel cans, the addition of just 2wt-% calcium stearate was shown to reduce the burning rate from 0.50cms(-1) to 0.09cms(-1). In this system, potassium chloride serves as a diluent that reduces incandesence but also increases slag formation. Compositions containing potassium chloride in the 25-30wt-% range exhibited both acceptably low incandescense and slag formation upon burning, while also producing copious amounts of white smoke. These experimental compositions were loaded into full-size grenade cans; field and smoke chamber testing revealed that they outperform the US Army's in-service M83 TA grenade both qualitatively and quantitatively. The photopic mass-based figures of merit for experimental grenades KCl-25, KCl-30, and a production-run M83 TA grenade were 2.51, 2.19, and 1.44m(2)g(-1), respectively. C1 [Shaw, Anthony P.; Poret, Jay C.; Gilbert, Robert A., Jr.] US Army RDECOM ARDEC, Armament Res Dev & Engn Ctr, Picatinny Arsenal, NJ 07806 USA. [Domanico, Joseph A.; Black, Ernest L.] US Army RDECOM ECBC, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. RP Shaw, AP (reprint author), US Army RDECOM ARDEC, Armament Res Dev & Engn Ctr, Picatinny Arsenal, NJ 07806 USA. EM anthony.p.shaw.civ@mail.mil FU US Army FX The authors thank Christopher M. Csernica for the use of his laboratory space and Karl D. Oyler for performing particle size measurements. Lawrence A. Bickford, Gary Chen, and Russell N. Broad are thanked for useful discussions. The US Army is thanked for funding this joint ARDEC-ECBC project through the RDECOM Environmental Quality Technology (EQT) Program. NR 27 TC 7 Z9 7 U1 1 U2 14 PU WILEY-V C H VERLAG GMBH PI WEINHEIM PA BOSCHSTRASSE 12, D-69469 WEINHEIM, GERMANY SN 0721-3115 EI 1521-4087 J9 PROPELL EXPLOS PYROT JI Propellants Explos. Pyrotech. PD OCT PY 2013 VL 38 IS 5 BP 622 EP 628 DI 10.1002/prep.201200166 PG 7 WC Chemistry, Applied; Engineering, Chemical SC Chemistry; Engineering GA 260KL UT WOS:000327593700004 ER PT J AU Zinnert, JC Shiflett, SA Vick, JK Young, DR AF Zinnert, Julie C. Shiflett, Sheri A. Vick, Jaclyn K. Young, Donald R. TI Plant functional traits of a shrub invader relative to sympatric native shrubs SO ECOSPHERE LA English DT Article DE Clethra alnifolia; Elaeagnus umbellata; electron transport rate; Fort AP Hill Virginia; functional traits; hydraulic conductivity; nitrogen; Vaccinium corymbosum; water use efficiency; woody expansion ID WATER-USE EFFICIENCY; HYDRAULIC CONDUCTIVITY; CARBON GAIN; LEAF; PHOTOSYNTHESIS; FOREST; NITROGEN; TREES; COORDINATION; ENCROACHMENT AB Woody expansion has been documented for years in many different systems, often the result of anthropogenic changes to the environment. Causes and consequences of woody expansion have been well documented, but comparatively few studies have focused on functional traits that mechanistically allow for dramatic expansion in range. Our objectives were to investigate functional traits and plant resource strategies that contribute to rapid expansion of an invasive, nitrogen-fixing shrub, Elaeagnus umbellata Thunb. (Elaeagnaceae) compared with two sympatric native shrubs, Clethra alnifolia L. (Clethraceae) and Vaccinium corymbosum L. (Ericaceae). We quantified morphological, physiological and biochemical functional traits linked explicitly to three main resources that directly influence plant growth: light, water and nutrients. We attribute high photosynthetic efficiency found in E. umbellata to traits associated with light capture and use (e.g., specific leaf area, pigment concentrations, leaf display). Compared to coexisting species, leaf-level water demand was supported through high hydraulic capacity, yet E. umbellata also maintained high water use efficiency evident in delta C-13 values. Fixed nitrogen allowed for higher foliar %N observed in E. umbellata. This supports both high rates of electron transport and hydraulic capacity as seen in the relationships between foliar %N and electron transport rate (ETR) and percent loss of conductivity (PLCmidday). Overall, functional traits of E. umbellata allowed for high resource acquisition that when combined contribute to success in a wide variety of habitats. Conversely, native sympatric shrubs exhibited functional traits representative of slower-growing species (e.g., lower light capture, water use and nutrient acquisition). Our results support the hypothesis that traits associated with photosynthesis, water use efficiency, specific leaf area and leaf N are under selective pressure and highlight the importance of relationships among photosynthetic efficiency, hydraulic capacity and leaf N content that allow for the success of an expanding woody species. C1 [Zinnert, Julie C.; Shiflett, Sheri A.; Vick, Jaclyn K.; Young, Donald R.] Virginia Commonwealth Univ, Dept Biol, Richmond, VA 23284 USA. [Zinnert, Julie C.] US Army Engn Res & Dev Ctr, Fluorescence Spect Lab, Alexandria, VA 22315 USA. RP Zinnert, JC (reprint author), Virginia Commonwealth Univ, Dept Biol, Richmond, VA 23284 USA. EM jczinnert@vcu.edu FU United States Army Research Office FX The authors thank Ava Hoffman for field assistance and Jared Austin for data entry. This research was support by a grant to DRY from the United States Army Research Office. Special thanks to John Sperry and Mairgareth Christman for demonstration of hydraulic conductivity measurements as well as Rick Collard who provided programming assistance for automated analytical balance readings. NR 52 TC 4 Z9 4 U1 4 U2 39 PU ECOLOGICAL SOC AMER PI WASHINGTON PA 1990 M STREET NW, STE 700, WASHINGTON, DC 20036 USA SN 2150-8925 J9 ECOSPHERE JI Ecosphere PD OCT PY 2013 VL 4 IS 10 AR UNSP 119 DI 10.1890/ES13-00111.1 PG 11 WC Ecology SC Environmental Sciences & Ecology GA 257JT UT WOS:000327380400002 ER PT J AU Ely, MR Kenefick, RW Cheuvront, SN Chinevere, T Lacher, CP Lukaski, HC Montain, SJ AF Ely, Matthew R. Kenefick, Robert W. Cheuvront, Samuel N. Chinevere, Troy Lacher, Craig P. Lukaski, Henry C. Montain, Scott J. TI The Effect of Heat Acclimation on Sweat Microminerals: Artifact of Surface Contamination SO INTERNATIONAL JOURNAL OF SPORT NUTRITION AND EXERCISE METABOLISM LA English DT Article DE calcium; copper; iron; magnesium; zinc ID TRACE-ELEMENTS; EXERCISE; IRON; ZINC; RESPONSES; EXCRETION; LOSSES; STRESS; METALS; HUMANS AB Heat acclimation (HA) reportedly conveys conservation in sweat micromineral concentrations when sampled from arm sweat, but time course is unknown. The observation that comprehensive cleaning of the skin surface negates sweat micromineral reductions during prolonged sweating raises the question of whether the reported HA effect is real or artifact of surface contamination. Purpose: To measure sweat mineral concentrations serially during HA and determine if surface contamination plays a role in the reported mineral reductions. Methods: Calcium (Ca), copper (Cu), magnesium (Mg), and zinc (Zn) were measured in sweat obtained from 17 male volunteers using an arm bag on Day 1, 5, and 10 of a HA protocol. To study the role of contamination, sweat was simultaneously (n = 10 subjects) sampled twice daily from a cleaned site (WASH) and unclean site (NO WASH) on the scapular surface. Results: Sweat Ca, Cu, and Mg from Arm Bag trended progressively downward from Day 1 to Day 10 of HA (p = .10-0.25). Micromineral concentrations from the WASH site did not change between Day 1, 5, or 10 (Ca = 0.30 +/- 0.12 mmol/L, Cu 0.41 +/- 0.53 mu mol/L; Zn 1.11 +/- 0.80 mu mol/L). Surface contamination can confound sweat mineral estimates, as sweat Ca and Cu from NO WASH site were initially higher than WASH (p < .05) but became similar to WASH when sampled serially. Conclusion: Heat acclimation does not confer reductions in sweat Ca, Cu, Mg, or Zn. When the skin surface is not cleaned, mineral residue inflates initial sweat mineral concentrations. Earlier reports of micromineral reductions during HA may have been confounded by interday cleaning variability. C1 [Ely, Matthew R.; Kenefick, Robert W.; Cheuvront, Samuel N.; Montain, Scott J.] US Army Res Inst Environm Med, Natick, MA USA. [Chinevere, Troy] David Grant Med Ctr, Travis AFB, CA USA. [Lacher, Craig P.; Lukaski, Henry C.] ARS, USDA, Human Nutr Res Ctr, Grand Forks, ND USA. RP Ely, MR (reprint author), US Army Res Inst Environm Med, Natick, MA USA. NR 36 TC 0 Z9 0 U1 2 U2 10 PU HUMAN KINETICS PUBL INC PI CHAMPAIGN PA 1607 N MARKET ST, PO BOX 5076, CHAMPAIGN, IL 61820-2200 USA SN 1526-484X EI 1543-2742 J9 INT J SPORT NUTR EXE JI Int. J. Sport Nutr. Exerc. Metab. PD OCT PY 2013 VL 23 IS 5 BP 470 EP 479 PG 10 WC Nutrition & Dietetics; Sport Sciences SC Nutrition & Dietetics; Sport Sciences GA 256BR UT WOS:000327285200006 PM 23535853 ER PT J AU Kerr, PC Donahue, AS Westerink, JJ Luettich, RA Zheng, LY Weisberg, RH Huang, Y Wang, HV Teng, Y Forrest, DR Roland, A Haase, AT Kramer, AW Taylor, AA Rhome, JR Feyen, JC Signell, RP Hanson, JL Hope, ME Estes, RM Dominguez, RA Dunbar, RP Semeraro, LN Westerink, HJ Kennedy, AB Smith, JM Powell, MD Cardone, VJ Cox, AT AF Kerr, P. C. Donahue, A. S. Westerink, J. J. Luettich, R. A., Jr. Zheng, L. Y. Weisberg, R. H. Huang, Y. Wang, H. V. Teng, Y. Forrest, D. R. Roland, A. Haase, A. T. Kramer, A. W. Taylor, A. A. Rhome, J. R. Feyen, J. C. Signell, R. P. Hanson, J. L. Hope, M. E. Estes, R. M. Dominguez, R. A. Dunbar, R. P. Semeraro, L. N. Westerink, H. J. Kennedy, A. B. Smith, J. M. Powell, M. D. Cardone, V. J. Cox, A. T. TI US IOOS coastal and ocean modeling testbed: Inter-model evaluation of tides, waves, and hurricane surge in the Gulf of Mexico SO JOURNAL OF GEOPHYSICAL RESEARCH-OCEANS LA English DT Review DE storm surge; tides; waves; testbed; hurricane; inundation ID SHALLOW-WATER EQUATIONS; LOWER MISSISSIPPI RIVER; SURFACE WIND FIELDS; STORM-SURGE; NUMERICAL COMPUTATIONS; UNSTRUCTURED GRIDS; SOUTHERN LOUISIANA; BOTTOM STRESS; FINITE-VOLUME; TAMPA BAY AB A Gulf of Mexico performance evaluation and comparison of coastal circulation and wave models was executed through harmonic analyses of tidal simulations, hindcasts of Hurricane Ike (2008) and Rita (2005), and a benchmarking study. Three unstructured coastal circulation models (ADCIRC, FVCOM, and SELFE) validated with similar skill on a new common Gulf scale mesh (ULLR) with identical frictional parameterization and forcing for the tidal validation and hurricane hindcasts. Coupled circulation and wave models, SWAN+ADCIRC and WWMII+SELFE, along with FVCOM loosely coupled with SWAN, also validated with similar skill. NOAA's official operational forecast storm surge model (SLOSH) was implemented on local and Gulf scale meshes with the same wind stress and pressure forcing used by the unstructured models for hindcasts of Ike and Rita. SLOSH's local meshes failed to capture regional processes such as Ike's forerunner and the results from the Gulf scale mesh further suggest shortcomings may be due to a combination of poor mesh resolution, missing internal physics such as tides and nonlinear advection, and SLOSH's internal frictional parameterization. In addition, these models were benchmarked to assess and compare execution speed and scalability for a prototypical operational simulation. It was apparent that a higher number of computational cores are needed for the unstructured models to meet similar operational implementation requirements to SLOSH, and that some of them could benefit from improved parallelization and faster execution speed. C1 [Kerr, P. C.; Donahue, A. S.; Westerink, J. J.; Hope, M. E.; Estes, R. M.; Dominguez, R. A.; Dunbar, R. P.; Semeraro, L. N.; Westerink, H. J.; Kennedy, A. B.] Univ Notre Dame, Dept Civil & Environm Engn & Earth Sci, South Bend, IN 46556 USA. [Luettich, R. A., Jr.] Univ N Carolina, Inst Marine Sci, Chapel Hill, NC USA. [Zheng, L. Y.; Weisberg, R. H.; Huang, Y.] Univ S Florida, Coll Marine Sci, St Petersburg, FL 33701 USA. [Wang, H. V.; Teng, Y.; Forrest, D. R.] Coll William & Mary, Virginia Inst Marine Sci, Williamsburg, VA USA. [Roland, A.] Tech Univ Darmstadt, Inst Hydraul & Water Resources Engn, Darmstadt, Germany. [Haase, A. T.; Kramer, A. W.; Taylor, A. A.] NOAA, Meteorol Dev Lab, Natl Weather Serv, Silver Spring, MD USA. [Rhome, J. R.] NOAA, Natl Weather Serv, Miami, FL USA. [Feyen, J. C.] NOAA, Natl Ocean Serv, Silver Spring, MD USA. [Signell, R. P.] US Geol Survey, Woods Hole Res Ctr, Woods Hole, MA 02543 USA. [Hanson, J. L.] US Army Corps Engineers, Engineer Res Dev Ctr, Vicksburg, MS USA. [Smith, J. M.] US Army Engineer Res & Dev Ctr, Coastal & Hydraul Lab, Vicksburg, MS USA. [Powell, M. D.] NOAA, Atlantic Oceanog & Meteorol Labs, Hurricane Res Div, Tallahassee, FL USA. [Cardone, V. J.; Cox, A. T.] Ocean Weather Inc, New Canaan, CT USA. RP Kerr, PC (reprint author), Univ Notre Dame, Dept Civil & Environm Engn & Earth Sci, 156 Fitzpatrick Hall, South Bend, IN 46556 USA. EM PCorbittKerr@gmail.com RI Kennedy, Andrew/E-4746-2011; Powell, Mark/I-4963-2013; OI Kennedy, Andrew/0000-0002-7254-1346; Powell, Mark/0000-0002-4890-8945; Donahue, Aaron/0000-0002-4710-753X; Signell, Richard/0000-0003-0682-9613 FU NOAA via the U.S. IOOS Office [NA10NOS0120063, NA11NOS0120141]; National Science Foundation [OCI-1053575] FX This project was supported by NOAA via the U.S. IOOS Office (award: NA10NOS0120063 and NA11NOS0120141) and was managed by the Southeastern Universities Research Association. In addition, this work used the Extreme Science and Engineering Discovery Environment (XSEDE), which is supported by National Science Foundation grant OCI-1053575. NR 104 TC 11 Z9 11 U1 7 U2 35 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA SN 2169-9275 EI 2169-9291 J9 J GEOPHYS RES-OCEANS JI J. Geophys. Res.-Oceans PD OCT PY 2013 VL 118 IS 10 BP 5129 EP 5172 DI 10.1002/jgrc.20376 PG 44 WC Oceanography SC Oceanography GA 257JQ UT WOS:000327380100026 ER PT J AU Mantzouris, T Gauer, R Mackler, L AF Mantzouris, Tammy Gauer, Robert Mackler, Leslie TI Elevated troponin but no CVD: What's the prognosis? SO JOURNAL OF FAMILY PRACTICE LA English DT Editorial Material ID ACUTE PULMONARY-EMBOLISM; TASK-FORCE; DIAGNOSIS; GUIDELINES; MANAGEMENT; MORTALITY; SOCIETY C1 [Mantzouris, Tammy] Gen Leonard Wood Army Community Hosp, Dept Primary Care, Ft Leonard Wood, MO USA. [Mantzouris, Tammy] Gen Leonard Wood Army Community Hosp, Med Clin, Ft Leonard Wood, MO USA. [Gauer, Robert] Womack Army Med Ctr, Dept Family Med, Ft Bragg, NC USA. [Mackler, Leslie] Moses Cone Hlth Lib, Greensboro, NC USA. RP Mantzouris, T (reprint author), Gen Leonard Wood Army Community Hosp, Dept Primary Care, Ft Leonard Wood, MO USA. NR 10 TC 1 Z9 1 U1 0 U2 1 PU DOWDEN HEALTH MEDIA PI MONTVALE PA 110 SUMMIT AVE, MONTVALE, NJ 07645-1712 USA SN 0094-3509 J9 J FAM PRACTICE JI J. Fam. Pract. PD OCT PY 2013 VL 62 IS 10 BP 585 EP + PG 3 WC Primary Health Care; Medicine, General & Internal SC General & Internal Medicine GA 253BD UT WOS:000327055700012 PM 24143353 ER PT J AU Newburgh, GA Dubinskii, M AF Newburgh, G. A. Dubinskii, M. TI A diode-pumped Nd:YVO4 thin disk laser with a hetero-composite gain element and dual-face cooling SO LASER PHYSICS LETTERS LA English DT Article ID DOPED YTTRIUM ORTHOVANADATE; WAVE-GUIDE LASER; THERMAL-EXPANSION; DOUBLE-CLAD; CRYSTALS; YVO4 AB We report on the first thin disk laser simultaneously cooled on two disk faces by the highly thermally conductive, optically transparent, single-crystalline medium, silicon carbide (SiC). The diode-pumped laser, based on a hetero-composite {SiC/Nd:YVO4/SiC} gain element, operated with a 26% slope efficiency in this first proof-of-concept experiment. Based on the performed Findlay-Clay analysis, the relatively low efficiency was attributed to high intracavity passive losses introduced by SiC components. C1 [Newburgh, G. A.; Dubinskii, M.] US Army Res Lab, Adelphi, MD 20783 USA. RP Newburgh, GA (reprint author), US Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM george.a.newburgh.civ@mail.mil NR 20 TC 1 Z9 1 U1 1 U2 11 PU IOP PUBLISHING LTD PI BRISTOL PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND SN 1612-2011 EI 1612-202X J9 LASER PHYS LETT JI Laser Phys. Lett. PD OCT PY 2013 VL 10 IS 10 AR 105807 DI 10.1088/1612-2011/10/10/105807 PG 4 WC Optics; Physics, Applied SC Optics; Physics GA 254IO UT WOS:000327158700027 ER PT J AU Jeffries, MO Overland, JE Perovich, DK AF Jeffries, Martin O. Overland, James E. Perovich, Donald K. TI THE ARCTIC shifts to a new normal SO PHYSICS TODAY LA English DT Article ID SEA C1 [Jeffries, Martin O.] US Arct Res Commiss, Arlington, VA 22203 USA. [Jeffries, Martin O.] Univ Alaska Fairbanks, Fairbanks, AK USA. [Overland, James E.] NOAA, Pacific Marine Environm Lab, Seattle, WA 98115 USA. [Overland, James E.] Univ Washington, Seattle, WA 98195 USA. [Perovich, Donald K.] US Armys Cold Regions Res & Engn Lab, Hanover, NH USA. [Perovich, Donald K.] Dartmouth Coll, Hanover, NH USA. RP Jeffries, MO (reprint author), US Arct Res Commiss, Arlington, VA 22203 USA. NR 15 TC 51 Z9 51 U1 3 U2 24 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0031-9228 EI 1945-0699 J9 PHYS TODAY JI Phys. Today PD OCT PY 2013 VL 66 IS 10 BP 35 EP 40 PG 6 WC Physics, Multidisciplinary SC Physics GA 252SY UT WOS:000327031800016 ER PT J AU Thomas, SJ Endy, TP AF Thomas, Stephen J. Endy, Timothy P. TI Current issues in dengue vaccination SO CURRENT OPINION IN INFECTIOUS DISEASES LA English DT Review DE dengue virus; development; vaccine ID PRIMARY-SCHOOL CHILDREN; CYNOMOLGUS MACAQUES; PROTECTIVE EFFICACY; VIRUS CHALLENGE; KAMPHAENG-PHET; TYPE-2 VIRUSES; ANIMAL-MODELS; TETRAVALENT; VACCINES; EVOLUTION AB Purpose of reviewDengue is a global health problem and of concern to travelers and deploying military personnel, with development and licensure of an effective tetravalent dengue vaccine a public health priority. The recent performance of the lead dengue vaccine in a phase 2b efficacy trial underscores dengue vaccine development challenges. This review focuses on current issues in dengue vaccination.Recent findingsThe dengue viruses (DENVs) are mosquito-borne flaviviruses transmitted by infected Aedes mosquitoes. Illness manifests across a clinical spectrum with severe disease characterized by intravascular volume depletion and hemorrhage. Recent estimates on the burden of DENV infection determined that there are 390 million dengue infections per year, three times the current estimate by the WHO. There are no licensed antivirals or vaccines to treat or prevent dengue though many are in preclinical or clinical development. DENV illness results from a complex interaction of viral properties and host immune responses. Immunologic complexity, lack of an adequate animal model of disease, absence of an immune correlate of protection, and only partially informative immunogenicity assays are challenging dengue vaccine development efforts.SummaryDengue vaccine development efforts have numerous complex challenges to overcome before a well tolerated and effective vaccine is licensed and available. In this review, the authors discuss the current issues in dengue vaccination. C1 [Thomas, Stephen J.] Walter Reed Army Inst Res, Dept Virol, Syracuse, NY USA. [Endy, Timothy P.] SUNY Upstate Med Univ, Dept Med, Div Infect Dis, Syracuse, NY 13210 USA. RP Endy, TP (reprint author), SUNY Upstate Med Univ, Dept Med, Div Infect Dis, 725 Irving Ave,Suite 304, Syracuse, NY 13210 USA. EM endyt@upstate.edu FU National Institutes of Health; Department of Defense FX One author (S.J.T.), as an employee of the United States Army, has been assigned to work on dengue vaccine co-development efforts with numerous commercial entities, some mentioned in this article. Author (T. P. E.) is a co-investigator on a phase 1 vaccine trial with Inviragen, on a data safety monitoring board for a dengue vaccine trial with Merck and Co., and receives research funds from the National Institutes of Health and the Department of Defense. NR 63 TC 11 Z9 11 U1 3 U2 25 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0951-7375 EI 1473-6527 J9 CURR OPIN INFECT DIS JI Curr. Opin. Infect. Dis. PD OCT PY 2013 VL 26 IS 5 BP 429 EP 434 DI 10.1097/01.qco.0000433310.28771.cc PG 6 WC Infectious Diseases SC Infectious Diseases GA 249WI UT WOS:000326810600005 PM 23963259 ER PT J AU McNutt, P Tuznik, K Nelson, M Adkins, A Lyman, M Glotfelty, E Hughes, J Hamilton, T AF McNutt, Patrick Tuznik, Kaylie Nelson, Marian Adkins, Angie Lyman, Megan Glotfelty, Elliot Hughes, James Hamilton, Tracey TI Structural, Morphological, and Functional Correlates of Corneal Endothelial Toxicity Following Corneal Exposure to Sulfur Mustard Vapor SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Article DE sulfur mustard; corneal endothelial cells; mustard gas; mustard gas keratopathy; corneal edema ID CONFOCAL MICROSCOPY; OCULAR LESIONS; GAS KERATITIS; INJURY; RABBITS; KERATOPATHY; KERATOPLASTY; KINETICS; ORIGIN; EYE AB PURPOSE. Sulfur mustard (SM) is a highly reactive vesicant that causes severe ocular injuries. Following exposure to moderate or high doses, a subset of victims develops a chronic injury known as mustard gas keratopathy (MGK) involving a keratitis of unknown etiopathogenesis with secondary keratopathies such as persistent epithelial lesions, corneal neovascularization, and progressive corneal degeneration. This study was designed to determine whether SM exposure evokes acute endothelial toxicity and to determine whether endothelial pathologies were specifically observed in MGK corneas as opposed to healed corneas. METHODS. Corneas of New Zealand white rabbits were exposed to SM vapor, and the corneal endothelium was evaluated at 1 day and 8 weeks using scanning electron microscopy (SEM), transmission electron microscopy (TEM), in vivo confocal microscopy (IVM), and fluorescent microscopy. Barrier function was measured by uptake of a fluorescent dye injected into the anterior chamber. RESULTS. A centripetal endothelial injury at 1 day was observed by SEM, TEM, IVM, and fluorescent microscopy. In vivo confocal microscopy revealed additional cytotoxicity between 1 and 13 days. In contrast to healed corneas, which appeared similar to sham-exposed naive eyes at 8 weeks, MGK corneas exhibited significant evidence of continued pathological changes in the endothelium. CONCLUSIONS. Endothelial toxicity occurs at the right time and with the appropriate pathophysiology to contribute to MGK. Based on these findings, we propose a model that explains the relationships among SM dose, the biphasic progression, and the various clinical trajectories of corneal SM injury and that provides a mechanism for temporal variations in MGK onset. Finally, we discuss the implications for the management of SM casualties. C1 [McNutt, Patrick; Tuznik, Kaylie; Nelson, Marian; Adkins, Angie; Lyman, Megan; Glotfelty, Elliot; Hughes, James; Hamilton, Tracey] US Army, Med Res Inst Chem Def, Aberdeen Proving Ground, MD 21010 USA. RP McNutt, P (reprint author), US Army, Med Res Inst Chem Def, Aberdeen Proving Ground, MD 21010 USA. EM Patrick.mcnutt@us.army.mil OI McNutt, Patrick/0000-0002-5703-4565 FU Defense Threat Reduction Agency-Joint Science and Technology Office, Medical Science and Technology Division Project [CMB.CUTOC.01.12.RC.006]; United States Army Medical Research Institute of Chemical Defense (USAMRICD) FX The authors thank Denise Kniffen, Kim Whitten, Paula Adkins, Lindsey Devine, Susan Schulz, Riannon Hazell, and Kathy King (USAMRICD) for the sustained technical and administrative support; Cindy Kronman (USAMRICD) for editorial assistance; and the program managers at the Defense Threat Reduction Agency for their support.; Supported by the Defense Threat Reduction Agency-Joint Science and Technology Office, Medical Science and Technology Division Project CMB.CUTOC.01.12.RC.006. The authors alone are responsible for the content and writing of the paper.; This research was performed when KT and EG held Oak Ridge Institute for Science and Education (ORISE) fellowships at the United States Army Medical Research Institute of Chemical Defense (USAMRICD), administered by ORISE through an inter-agency agreement between the US Department of Energy and the USAMRMC. NR 34 TC 4 Z9 4 U1 0 U2 4 PU ASSOC RESEARCH VISION OPHTHALMOLOGY INC PI ROCKVILLE PA 12300 TWINBROOK PARKWAY, ROCKVILLE, MD 20852-1606 USA SN 0146-0404 EI 1552-5783 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD OCT PY 2013 VL 54 IS 10 BP 6735 EP 6744 DI 10.1167/iovs.13-12402 PG 10 WC Ophthalmology SC Ophthalmology GA 246VI UT WOS:000326567700032 PM 24045986 ER PT J AU Lacouture, S Lawson, K Bayne, S Giesselmann, M Scozzie, CJ O'Brien, H Ogunniyi, AA AF Lacouture, Shelby Lawson, Kevin Bayne, Stephen Giesselmann, Michael Scozzie, Charles J. O'Brien, Heather Ogunniyi, Aderinto A. TI Automated modular high energy evaluation system for experimental thyristor devices SO REVIEW OF SCIENTIFIC INSTRUMENTS LA English DT Article AB A high energy, modular, completely automated test bed with integrated data acquisition and characterization systems was successfully designed in order to perform both safe operating area as well as very high volume reliability testing on experimental silicon carbide Super Gate Turn Off (SGTO) thyristors. Although the system follows a modular design philosophy, with each functional block acting as a peripheral to a main control module and can be adapted to arbitrary power and pulse width levels, for the specific SGTO devices initially evaluated it was configured to have the device discharge variable current levels of up to 6 kA into a 0.5 Omega resistive load with a relatively square pulse fixed at 100 mu s full width at half maximum delivering energy levels up to 1.8 kJ to the load. (C) 2013 AIP Publishing LLC. C1 [Lacouture, Shelby; Lawson, Kevin; Bayne, Stephen; Giesselmann, Michael] Texas Tech Univ, Dept Elect Engn, Lubbock, TX 79409 USA. [Scozzie, Charles J.; O'Brien, Heather; Ogunniyi, Aderinto A.] US Army Res Lab, Adelphi, MD 20783 USA. RP Lacouture, S (reprint author), Texas Tech Univ, Dept Elect Engn, 1012 Boston Ave, Lubbock, TX 79409 USA. FU Army Research Laboratory [W911NF-10-2-0018] FX We would like to thank Army Research Laboratory (Contract No. W911NF-10-2-0018) for supporting this work and for lending their technical expertise. NR 9 TC 3 Z9 3 U1 0 U2 2 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0034-6748 EI 1089-7623 J9 REV SCI INSTRUM JI Rev. Sci. Instrum. PD OCT PY 2013 VL 84 IS 10 AR 105108 DI 10.1063/1.4823525 PG 7 WC Instruments & Instrumentation; Physics, Applied SC Instruments & Instrumentation; Physics GA 247TS UT WOS:000326645300073 PM 24182164 ER PT J AU Becker, CR Strawhecker, KE McAllister, QP Lundgren, CA AF Becker, Collin R. Strawhecker, Kenneth E. McAllister, Quinn P. Lundgren, Cynthia A. TI In Situ Atomic Force Microscopy of Lithiation and Delithiation of Silicon Nanostructures for Lithium Ion Batteries SO ACS NANO LA English DT Article DE electron beam lithography; lithium ion batteries; atomic force microscopy; silicon; porous silicon ID ELECTROCHEMICAL LITHIATION; PROPYLENE CARBONATE; AMORPHOUS-SILICON; THIN-FILMS; ELECTRODES; EVOLUTION; ANODES; LI; NANOWIRES; INSERTION AB Using electron beam lithography, amorphous Si (a-Si) nanopillars were fabricated with a height of 100 nm and diameters of 100, 200, 300, 500, and 1000 nm. The nanopillars were electrochemically cycled in a 1 M lithium trifluoromethanesulfonate in propylene carbonate electrolyte. In situ atomic force microscopy (AFM) was used to qualitatively and quantitatively examine the morphology evolution of the nanopillars including volume and height changes versus voltage in real-time. In the first cycle, an obvious hysteresis of volume change versus voltage during lithiation and delithiation was measured. The pillars did not crack in the first cycle, but a permanent volume expansion was observed. During subsequent cycles the a-Si roughened and deformed from the initial geometry, and eventually pillars with diameters >200 nm fractured. Furthermore, a degradation of mechanical properties is suggested as the 100 and 200 nm pillars were mechanically eroded by the small contact forces under the AFM probe. Ex situ scanning electron microscopy (SEM) Images, combined with analysis of the damage caused by in situ AFM imaging, demonstrate that during cycling, the silicon became porous and structurally unstable compared to as-fabricated pillars. This research highlights that even nanoscale a-Si suffers Irreversible mechanical damage during cycling In organic electrolytes. C1 [Becker, Collin R.; Lundgren, Cynthia A.] ATTN RDRL SED C, Sensors & Elect Devices Directorate, Energy & Power Div, US Army Res Lab, Adelphi, MD 20783 USA. [Strawhecker, Kenneth E.] ATTN RDRL WMM G, Weap & Mat Res Directorate, Mat & Mfg Sci Div, US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA. [McAllister, Quinn P.] ATTN RDRL WMM B, Weap & Mat Res Directorate, Mat & Mfg Sci Div, US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Becker, CR (reprint author), ATTN RDRL SED C, Sensors & Elect Devices Directorate, Energy & Power Div, US Army Res Lab, Adelphi, MD 20783 USA. EM collin.r.becker.civ@mail.mit FU Army Research Laboratory; Postgraduate Research Participant Program at the U.S. Army Research Laboratory FX The authors acknowledge Dr. Josh Ratchford for his assistance in fabrication of samples. The authors also gratefully acknowledge insightful discussion with Dr. Jeffrey B. Wolfenstine and Dr. Jeffrey A. Read. The authors are grateful to the Army Research Laboratory for financial support. This research was supported in part by an appointment to the Postgraduate Research Participant Program at the U.S. Army Research Laboratory administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the U.S. Department of Energy and USARL. NR 34 TC 35 Z9 36 U1 6 U2 101 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1936-0851 EI 1936-086X J9 ACS NANO JI ACS Nano PD OCT PY 2013 VL 7 IS 10 BP 9173 EP 9182 DI 10.1021/nn4037909 PG 10 WC Chemistry, Multidisciplinary; Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary SC Chemistry; Science & Technology - Other Topics; Materials Science GA 242AF UT WOS:000326209100091 PM 23992113 ER PT J AU Farrow, B Hong, SA Romero, EC Lai, B Coppock, MB Deyle, KM Finch, AS Stratis-Cullum, DN Agnew, HD Yang, S Heath, JR AF Farrow, Blake Hong, Sung A. Romero, Errika C. Lai, Bert Coppock, Matthew B. Deyle, Kaycie M. Finch, Amethist S. Stratis-Cullum, Dimitra N. Agnew, Heather D. Yang, Sung Heath, James R. TI A Chemically Synthesized Capture Agent Enables the Selective, Sensitive, and Robust Electrochemical Detection of Anthrax Protective Antigen SO ACS NANO LA English DT Article DE pathogens; biosensing; electrochemistry; nanomaterial; ELISA; anthrax; protein capture agents ID SITU CLICK CHEMISTRY; LINKED-IMMUNOSORBENT-ASSAY; NANOPOROUS GOLD ELECTRODE; BACILLUS-ANTHRACIS; ANTIBODIES; SAMPLES; TOXIN; IMMUNOASSAYS; MONOLAYERS; BIOMARKER AB We report on a robust and sensitive approach for detecting protective antigen (PA) exotoxin from Bacillus anthracis in complex media. A peptide-based capture agent against PA was developed by improving a bacteria display-developed peptide into a highly selective biligand through in situ click screening against a large, chemically synthesized peptide library. This biligand was coupled with an electrochemical enzyme-linked immunosorbent assay utilizing nanostructured gold electrodes. The resultant assay yielded a limit of detection of PA of 170 pg/mL. (2.1 pM) in buffer, with minimal sensitivity reduction in 1% serum. The powdered capture agent could be stably stored for several days at 65 degrees C, and the full electrochemical biosensor showed no loss of performance after extended storage at 40 degrees C. The engineered stability and specificity of this assay should be extendable to other cases in which biomolecular detection in demanding environments is required. C1 [Farrow, Blake] CALTECH, Dept Appl Phys & Mat Sci, Pasadena, CA 91125 USA. [Farrow, Blake; Romero, Errika C.; Deyle, Kaycie M.; Heath, James R.] CALTECH, Div Chem & Chem Engn, Pasadena, CA 91125 USA. [Hong, Sung A.; Yang, Sung] Gwangju Inst Sci & Technol, Dept Med Syst Engn, Kwangju 500712, South Korea. [Lai, Bert; Agnew, Heather D.] Indi Mol, Culver City, CA 90230 USA. [Coppock, Matthew B.; Finch, Amethist S.; Stratis-Cullum, Dimitra N.] US Army Res Lab, Sensors & Elect Devices Directorate, Biotechnol Branch, Adelphi, MD 20783 USA. RP Yang, S (reprint author), Gwangju Inst Sci & Technol, Dept Med Syst Engn, Kwangju 500712, South Korea. EM syang@gist.ac.kr; heath@caltech.edu RI Stratis-Cullum, Dimitra/F-9363-2013; OI Stratis-Cullum, Dimitra/0000-0002-4832-6945; Farrow, Blake/0000-0002-1007-7111 FU U.S. Army Research Office, Institute for Collaborative Biotechnologies [W911NF-09-0001]; U.S. Army Research Laboratory; National Research Foundation of Korea, Korean Government (MEST) [2011-0028861]; Institute of Medical System Engineering (iMSE) of GIST, Republic of Korea FX This research was funded primarily provided by the Institute for Collaborative Biotechnologies through grant W911NF-09-0001 from the U.S. Army Research Office. Research is supported in part by appointments (M.B.C.) to the U.S. Army Research Laboratory Postdoctoral Fellowship Program administered by the Oak Ridge Associated Universities through a contract with the U.S. Army Research Laboratory. The content of the information does not necessarily reflect the position or the policy of the Government, and no official endorsement should be inferred. The research was partially supported by the National Research Foundation of Korea Grant funded by the Korean Government (MEST) (2011-0028861), and a grant from the Institute of Medical System Engineering (iMSE) of GIST, Republic of Korea. The authors would like to thank J. M. Kogot, D. A. Sarkes, and P. M. Pellegrino for their contributions towards the previous discovery of anti-protective antigen peptide sequences. The following reagents were obtained through the NIH Biodefense and Emerging Infections Research Resources Repository, NIAID, NIH: Anthrax Protective Antigen (PA), recombinant from E. coli, NR-3780. NR 40 TC 24 Z9 24 U1 5 U2 78 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1936-0851 EI 1936-086X J9 ACS NANO JI ACS Nano PD OCT PY 2013 VL 7 IS 10 BP 9452 EP 9460 DI 10.1021/nn404296k PG 9 WC Chemistry, Multidisciplinary; Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary SC Chemistry; Science & Technology - Other Topics; Materials Science GA 242AF UT WOS:000326209100119 PM 24063758 ER PT J AU Truong, KV Yeo, H Ormiston, RA AF Khiem-Van Truong Yeo, Hyeonsoo Ormiston, Robert A. TI Structural dynamics modeling of rectangular rotor blades SO AEROSPACE SCIENCE AND TECHNOLOGY LA English DT Article DE Helicopter rotor; Flexible blade structure; 1-D and 3-D structural modeling; Blade natural frequencies ID SECTIONAL ANALYSIS; COMPOSITE BEAMS AB This study investigates 1-D and 3-D methods for modeling helicopter rotor blade structural dynamics to better understand the accuracy of current structural modeling based on 1-D beam theory. Natural frequencies are calculated at various rotor angular speeds for a large variety of blades ranging from simple isotropic beams to a realistic composite blade. The blade shape is limited to rectangular planforms, but various lengths are considered. 1-D beam analysis is conducted using the RCAS rotorcraft comprehensive analysis with 2-D cross-sectional properties calculated from VASS. 3-D finite element analysis is based on the commercial code MSC/Marc. Accuracy of both 1-D and 3-D analyses have been assessed through analysis of discretization errors that originate from insufficiently refined meshing. There is very good agreement between 1-D and 3-D predictions for the eight lowest modes of a large variety of blades, when there is no coupling between modes of different nature (flap, torsion) induced by materials and when the blade length is greater than ten times chord. Effects of blade length for isotropic and composite beams with no coupling between modes are similarly predicted by 1-D and 3-D analyses, except for torsion frequency, where 1-D analysis closely follows classical beam theory. With the presence of flap-torsion coupling between modes, the two approaches differ on prediction of the torsion-dominant frequency and significantly on the flap-dominant frequency. (C) 2013 Elsevier Masson SAS. All rights reserved. C1 [Khiem-Van Truong] Off Natl Etud & Rech Aerosp, DADS, Chatillon, France. [Yeo, Hyeonsoo; Ormiston, Robert A.] US Army, Aviat Dev Directorate AFDD, Ames Res Ctr, Aviat & Missile Res Dev & Engn Ctr,Res Dev & Engn, Moffett Field, CA USA. RP Truong, KV (reprint author), Off Natl Etud & Rech Aerosp, DADS, Chatillon, France. EM khiem-van.truong@onera.fr; hyeonsoo.yeo@us.army.mil; robert.ormiston@us.army.mil OI TRUONG, Van Khiem/0000-0002-3236-0751 NR 30 TC 3 Z9 3 U1 1 U2 8 PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER PI PARIS PA 23 RUE LINOIS, 75724 PARIS, FRANCE SN 1270-9638 EI 1626-3219 J9 AEROSP SCI TECHNOL JI Aerosp. Sci. Technol. PD OCT PY 2013 VL 30 IS 1 BP 293 EP 305 DI 10.1016/j.ast.2013.08.014 PG 13 WC Engineering, Aerospace SC Engineering GA 244BK UT WOS:000326361900031 ER PT J AU Herrera, RA AF Herrera, Ricardo A. TI "Light Horse Harry" Lee in the War for Independence: A Military Biography of Robert E. Lee's Father. SO JOURNAL OF MILITARY HISTORY LA English DT Book Review C1 [Herrera, Ricardo A.] US Army Command & Gen Staff Coll, Ft Leavenworth, KS USA. RP Herrera, RA (reprint author), US Army Command & Gen Staff Coll, Ft Leavenworth, KS USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU SOC MILITARY HISTORY PI LEXINGTON PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA 24450-1600 USA SN 0899-3718 EI 1543-7795 J9 J MILITARY HIST JI J. Mil. Hist. PD OCT PY 2013 VL 77 IS 4 BP 1455 EP 1457 PG 3 WC History SC History GA 244RV UT WOS:000326408700021 ER PT J AU Stowe, CS AF Stowe, Christopher S. TI This Distracted and Anarchical People: New Answers for Old Questions about the Civil War-Era North SO JOURNAL OF MILITARY HISTORY LA English DT Book Review C1 [Stowe, Christopher S.] US Army Command & Gen Staff Coll, Ft Lee, VA USA. RP Stowe, CS (reprint author), US Army Command & Gen Staff Coll, Ft Lee, VA USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU SOC MILITARY HISTORY PI LEXINGTON PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA 24450-1600 USA SN 0899-3718 EI 1543-7795 J9 J MILITARY HIST JI J. Mil. Hist. PD OCT PY 2013 VL 77 IS 4 BP 1477 EP 1478 PG 2 WC History SC History GA 244RV UT WOS:000326408700036 ER PT J AU Connelly, DB AF Connelly, Donald B. TI Progressives at War: William G. McAdoo and Newton D. Baker, 1863-1941 SO JOURNAL OF MILITARY HISTORY LA English DT Book Review C1 [Connelly, Donald B.] US Army Command & Gen Staff Coll, Ft Leavenworth, KS USA. RP Connelly, DB (reprint author), US Army Command & Gen Staff Coll, Ft Leavenworth, KS USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU SOC MILITARY HISTORY PI LEXINGTON PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA 24450-1600 USA SN 0899-3718 EI 1543-7795 J9 J MILITARY HIST JI J. Mil. Hist. PD OCT PY 2013 VL 77 IS 4 BP 1506 EP 1507 PG 2 WC History SC History GA 244RV UT WOS:000326408700056 ER PT J AU Kuehn, JT AF Kuehn, John T. TI A Companion to World War II, 2 vols SO JOURNAL OF MILITARY HISTORY LA English DT Book Review C1 [Kuehn, John T.] US Army Command & Gen Staff Coll, Ft Leavenworth, KS USA. RP Kuehn, JT (reprint author), US Army Command & Gen Staff Coll, Ft Leavenworth, KS USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU SOC MILITARY HISTORY PI LEXINGTON PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA 24450-1600 USA SN 0899-3718 EI 1543-7795 J9 J MILITARY HIST JI J. Mil. Hist. PD OCT PY 2013 VL 77 IS 4 BP 1515 EP 1516 PG 2 WC History SC History GA 244RV UT WOS:000326408700062 ER PT J AU Citino, RM AF Citino, Robert M. TI The Liberation Trilogy, Vol. III: The Guns at Last Light: The War in Western Europe, 1944-1945 SO JOURNAL OF MILITARY HISTORY LA English DT Book Review C1 [Citino, Robert M.] US Army War Coll, Carlisle, PA USA. RP Citino, RM (reprint author), US Army War Coll, Carlisle, PA USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU SOC MILITARY HISTORY PI LEXINGTON PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA 24450-1600 USA SN 0899-3718 EI 1543-7795 J9 J MILITARY HIST JI J. Mil. Hist. PD OCT PY 2013 VL 77 IS 4 BP 1525 EP 1526 PG 2 WC History SC History GA 244RV UT WOS:000326408700069 ER PT J AU Cirillo, R AF Cirillo, Roger TI "Operation Market Garden: Arnhem, the Battle for the Bridges" SO JOURNAL OF MILITARY HISTORY LA English DT Book Review C1 [Cirillo, Roger] Assoc US Army, Arlington, VA USA. RP Cirillo, R (reprint author), Assoc US Army, Arlington, VA USA. NR 1 TC 0 Z9 0 U1 0 U2 1 PU SOC MILITARY HISTORY PI LEXINGTON PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA 24450-1600 USA SN 0899-3718 EI 1543-7795 J9 J MILITARY HIST JI J. Mil. Hist. PD OCT PY 2013 VL 77 IS 4 BP 1528 EP 1530 PG 3 WC History SC History GA 244RV UT WOS:000326408700072 ER PT J AU Cirillo, R AF Cirillo, Roger TI September Hope: The American Side of a Bridge Too Far SO JOURNAL OF MILITARY HISTORY LA English DT Book Review C1 [Cirillo, Roger] Assoc US Army, Arlington, VA USA. RP Cirillo, R (reprint author), Assoc US Army, Arlington, VA USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU SOC MILITARY HISTORY PI LEXINGTON PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA 24450-1600 USA SN 0899-3718 EI 1543-7795 J9 J MILITARY HIST JI J. Mil. Hist. PD OCT PY 2013 VL 77 IS 4 BP 1528 EP 1530 PG 3 WC History SC History GA 244RV UT WOS:000326408700071 ER PT J AU Kissin, EY Niu, JB Balint, P Bong, D Evangelisto, A Goyal, J Higgs, J Malone, D Nishio, MJ Pineda, C Schmidt, WA Thiele, RG Torralba, KD Kaeley, GS AF Kissin, Eugene Y. Niu, Jingbo Balint, Peter Bong, David Evangelisto, Amy Goyal, Janak Higgs, Jay Malone, Daniel Nishio, Midori J. Pineda, Carlos Schmidt, Wolfgang A. Thiele, Ralf G. Torralba, Karina D. Kaeley, Gurjit S. TI Musculoskeletal Ultrasound Training and Competency Assessment Program for Rheumatology Fellows SO JOURNAL OF ULTRASOUND IN MEDICINE LA English DT Article DE competency; education; examination; musculoskeletal; ultrasound ID ULTRASONOGRAPHY; INTELLIGENCE; FEEDBACK; WRITTEN; SKILLS; OSCE AB Objectives-The purpose of this study was to establish standards for musculoskeletal ultrasound competency through knowledge and skills testing using criterion-referenced methods. Methods-Two groups of rheumatology fellows trained in musculoskeletal ultrasound through a standardized curriculum, which required submission of ultrasound studies for review over 8 months. Both groups then completed written and practical examinations in musculoskeletal ultrasound. Instructors, advanced users, and intermediate users of musculoskeletal ultrasound served as comparison groups. A passing score (competency) was established for the written examination by the Angoff procedure and for the practical examination by the borderline method. Results-Thirty-eight fellows (19 in each group) took the final examination. Five fellows failed the written examination, and 1 failed the practical examination, whereas none of the advanced users failed. Written examination scores did not differ between the two fellow groups (74% versus 70%; P > .05), were reliable, and were able to discriminate between the intermediate and advanced groups. Practical and written examination results correlated in both groups (first group, r = 0.70; P = .0008; second group, r = 0.59; P = .009). Conclusions-Criterion-referenced methods were used for the first time to determine fellow musculoskeletal ultrasound competency. The examination used to determine competency was reproducible, was reliable, and could differentiate musculoskeletal ultrasound users with different levels of experience. Most rheumatology fellows completing our program passed the written and practical examinations, suggesting achievement of basic musculoskeletal ultrasound competency. C1 [Kissin, Eugene Y.; Niu, Jingbo] Boston Univ, Sch Med, Boston, MA 02118 USA. [Balint, Peter] Natl Inst Rheumatism & Physiotherapy, Budapest, Hungary. [Bong, David] Inst Poal Reumatl, Barcelona, Spain. [Evangelisto, Amy] Arthrit Rheumat & Back Dis Associates, Voorhees, NJ USA. [Goyal, Janak] Raritan Bay Med Ctr, Perth Amboy, NJ USA. [Higgs, Jay] Brooke Army Med Ctr, Dept Rheumatol, San Antonio, TX USA. [Malone, Daniel] Excel Orthoped, Beaver Dam, WI USA. [Nishio, Midori J.] Nishio & Sharma MDs, Walnut Creek, CA USA. [Pineda, Carlos] Inst Nacl Rehabil, Dept Biomed Res, Mexico City, DF, Mexico. [Schmidt, Wolfgang A.] Med Ctr Rheumatol Berlin Buch, Berlin, Germany. [Thiele, Ralf G.] Univ Rochester, Dept Rheumatol, Rochester, NY USA. [Torralba, Karina D.] Univ So Calif, Keck Sch Med, Los Angeles, CA 90033 USA. [Kaeley, Gurjit S.] Univ Florida, Dept Rheumatol, Jacksonville, FL USA. RP Kissin, EY (reprint author), Boston Univ, Sch Med, Arthrit Ctr, 72 East Concord St,Evans 506, Boston, MA 02118 USA. EM eukissin@bu.edu FU American College of Rheumatology Research and Education Foundation Clinician Scholar Educator Award FX We thank Drs Sebastian Arriola, Araceli Bernal, Efren Canul, Mario Chavez, Jurgen Craig-Muller, Aleksander Feoktistov, Moises Gutierrez, Cristina Hemandez-Diaz, Fritz Hofmann, Robert Ike, Rafael Kieval, Paul Monach, Carlos Moya, Raul Pacheco, Hugo Pena, Pedro Rodriguez, Burton Sack, Jonathan Samuels, Carla Solano, Darren Tabechian, Leobardo Teran, Lucio Ventura, Alvin Wells, and Thomas Wiegemann for help with the creation of the written examination; Drs Rany Al Haj and Paul DeMarco for help with the Angoff procedure; and Biosound Esaote, Diagnostic Instruments, Inc, GE Healthcare, and SonoSite, Inc, for supplying ultrasound equipment and technical expertise for the practical examination. Funding for this project was provided by an American College of Rheumatology Research and Education Foundation Clinician Scholar Educator Award. The views expressed herein are those of the authors and do not reflect the official policy or position of Brooke Army Medical Center, the US Army Medical Department, the US Army Office of the Surgeon General, the US Department of the Army, the US Air Force, the US Department of Defense, or the US Government. NR 28 TC 11 Z9 11 U1 0 U2 1 PU AMER INST ULTRASOUND MEDICINE PI LAUREL PA SUBSCRIPTION DEPT, 14750 SWEITZER LANE, STE 100, LAUREL, MD 20707-5906 USA SN 0278-4297 EI 1550-9613 J9 J ULTRAS MED JI J. Ultrasound Med. PD OCT PY 2013 VL 32 IS 10 BP 1735 EP 1743 DI 10.7863/ultra.32.10.1735 PG 9 WC Acoustics; Radiology, Nuclear Medicine & Medical Imaging SC Acoustics; Radiology, Nuclear Medicine & Medical Imaging GA 243ZN UT WOS:000326357000007 PM 24065254 ER PT J AU Li, JT Cushing, SK Zheng, P Meng, FK Chu, D Wu, NQ AF Li, Jiangtian Cushing, Scott K. Zheng, Peng Meng, Fanke Chu, Deryn Wu, Nianqiang TI Plasmon-induced photonic and energy-transfer enhancement of solar water splitting by a hematite nanorod array SO NATURE COMMUNICATIONS LA English DT Article ID EXTRAORDINARY OPTICAL-TRANSMISSION; PHOTOCATALYTIC ACTIVITY; HOLE ARRAYS; NANOPARTICLES; ABSORPTION; CELLS; METAL; FILMS; OXIDE; TIO2 AB Plasmonic metal nanostructures offer a promising route to improve the solar energy conversion efficiency of semiconductors. Here we show that incorporation of a hematite nanorod array into a plasmonic gold nanohole array pattern significantly improves the photoelectrochemical water splitting performance, leading to an approximately tenfold increase in the photocurrent at a bias of 0.23V versus Ag vertical bar AgCl under simulated solar radiation. Plasmon-induced resonant energy transfer is responsible for enhancement at the energies below the band edge, whereas above the absorption band edge of hematite, the surface plasmon polariton launches a guided wave mode inside the nanorods, with the nanorods acting as miniature optic fibres, enhancing the light absorption. In addition, the intense local plasmonic field can suppress the charge recombination in the hematite nanorod photoanode in a photoelectrochemical cell. Our results may provide a general approach to overcome the low optical absorption and spectral utilization of thin semiconductor nanostructures, while further reducing charge recombination losses. C1 [Li, Jiangtian; Cushing, Scott K.; Zheng, Peng; Meng, Fanke; Wu, Nianqiang] W Virginia Univ, Dept Mech & Aerosp Engn, Morgantown, WV 26506 USA. [Cushing, Scott K.] W Virginia Univ, Dept Phys & Astron, Morgantown, WV 26506 USA. [Chu, Deryn] US Army Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA. RP Wu, NQ (reprint author), W Virginia Univ, Dept Mech & Aerosp Engn, Morgantown, WV 26506 USA. EM nick.wu@mail.wvu.edu RI Li, Jiangtian/D-6945-2011; Meng, Fanke /F-3978-2010; Wu, Nianqiang/B-9798-2015; Meng, Fanke/D-7395-2017 OI Wu, Nianqiang/0000-0002-8888-2444; Meng, Fanke/0000-0001-7961-4248 FU National Science Foundation [CBET-1233795]; NSF [1102689, EPS 1003907]; West Virginia University Research Corporation; West Virginia EPSCoR Office FX This work was supported by the National Science Foundation (CBET-1233795) and NSF Graduate Research Fellowship (1102689). The resource and facilities used were partially supported by NSF (EPS 1003907), the West Virginia University Research Corporation and the West Virginia EPSCoR Office. The use of WVU Shared Facility was appreciated. NR 53 TC 107 Z9 107 U1 50 U2 385 PU NATURE PUBLISHING GROUP PI LONDON PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND SN 2041-1723 J9 NAT COMMUN JI Nat. Commun. PD OCT PY 2013 VL 4 AR 2651 DI 10.1038/ncomms3651 PG 8 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 245OI UT WOS:000326472600003 PM 24136178 ER PT J AU Yego, ECK Dillman, JF AF Yego, E. Chepchumba K. Dillman, James F., III TI Cytokine regulation by MAPK activated kinase 2 in keratinocytes exposed to sulfur mustard SO TOXICOLOGY IN VITRO LA English DT Article DE Sulfur mustard; MK2/MAPKAPK2; p38; Keratinocytes; Cytokine; Vesicant ID NECROSIS-FACTOR-ALPHA; NUCLEAR EXPORT; CELL-DEATH; OFF-TARGET; TNF-ALPHA; IN-VITRO; SKIN; PROTEIN-KINASE-2; EXPRESSION; PHOSPHORYLATION AB Uncontrolled inflammation contributes to cutaneous damage following exposure to the warfare agent bis(2-chloroethyl) sulfide (sulfur mustard, SM). Activation of the p38 mitogen activated protein kinase (MAPK) precedes SM-induced cytokine secretion in normal human epidermal keratinocytes (NHEKs). This study examined the role of p38-regulated MAPK activated kinase 2 (MK2) during this process. Time course analysis studies using NHEK cells exposed to 200 mu M SM demonstrated rapid MK2 activation via phosphorylation that occurred within 15 min. p38 activation was necessary for MK2 phosphorylation as determined by studies using the p38 inhibitor SB203580. To compare the role of p38 and MK2 during SM-induced cytokine secretion, small interfering RNA (siRNA) targeting these proteins was utilized. TNF-alpha, IL-1 beta, IL-6 and IL-8 secretion was evaluated 24 h postexposure, while mRNA changes were quantified after 8 h. TNF-alpha, IL-6 and IL-8 up regulation at the protein and mRNA level was observed following SM exposure. IL-1 beta secretion was also elevated despite unchanged mRNA levels. p38 knockdown reduced SM-induced secretion of all the cytokines examined, whereas significant reduction in SM-induced cytokine secretion was only observed with TNF-alpha and IL-6 following MK2 knockdown. Our observations demonstrate potential activation of other p38 targets in addition to MK2 during SM-induced cytokine secretion. (C) 2013 Published by Elsevier Ltd. C1 [Yego, E. Chepchumba K.; Dillman, James F., III] US Army, Cell & Mol Biol Branch, Med Res Inst Chem Def, Aberdeen Proving Ground, MD 21010 USA. RP Yego, ECK (reprint author), US Army, Cell & Mol Biol Branch, Med Res Inst Chem Def, 3100 Ricketts Point Rd, Aberdeen Proving Ground, MD 21010 USA. EM echepchumba.k.yego.ctr@us.army.mil; james.f.dillman2.civ@mail.mil FU Defense Threat Reduction Agency - Joint Science and Technology Office, Medical ST Division FX We thank Ms. Theresa Nipwoda and Mr. Eric Nealley for assistance with cell culture. We are thankful to Dr. Brian Keyser, Dr. Albert Ruff and Dr. Timothy Varney for reviewing this manuscript. We would also like to thank Ms. Cristin Rothwell, Mr. Alex Katos, Ms. Chelsea Crum and SPC Wei Niu for technical assistance and Dr. Heidi Hoard-Fruchey for assistance with data analysis. This research was supported by the Defense Threat Reduction Agency - Joint Science and Technology Office, Medical S&T Division. Dr. Yego is a research associate with the National Research Council. NR 55 TC 2 Z9 2 U1 0 U2 6 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0887-2333 J9 TOXICOL IN VITRO JI Toxicol. Vitro PD OCT PY 2013 VL 27 IS 7 BP 2067 EP 2075 DI 10.1016/j.tiv.2013.07.002 PG 9 WC Toxicology SC Toxicology GA 244BB UT WOS:000326361000006 PM 23851002 ER PT J AU Oter, K Gunay, F Tuzer, E Linton, YM Bellini, R Alten, B AF Oter, Kerem Gunay, Filiz Tuzer, Erkut Linton, Yvonne-Marie Bellini, Romeo Alten, Bulent TI First Record of Stegomyia albopicta in Turkey Determined By Active Ovitrap Surveillance and DNA Barcoding SO VECTOR-BORNE AND ZOONOTIC DISEASES LA English DT Article DE Stegomyia albopicta; Aedes albopictus; Turkey; Establishment; DNA barcoding ID MOSQUITO AEDES-ALBOPICTUS; WEST-NILE-VIRUS; DIPTERA-CULICIDAE; VECTOR COMPETENCE; EMILIA-ROMAGNA; SPREAD; TIGER; ESTABLISHMENT; DISPERSAL; INVASION AB Despite its confirmed establishment in neighboring Greece and Bulgaria, the presence of the Oriental invasive species Stegomyia albopicta (Skuse) (=Aedes albopictus) has never been confirmed in Turkey. Active surveillance for this container-breeding species was carried out using oviposition traps at 15 discrete sites in the towns of Ipsala (n=8 sites), Kesan (n=5) (Edirne District), and Malkara (n=2) (Tekirdag District) in the Thrace region of northwestern Turkey, from May 23 through November 10, 2011. Eggs collected were reared to the fourth larval instar and adult stages where possible to facilitate integrated morphological and molecular species identification. DNA barcodes (658bp of the mitochondrial cytochrome c oxidase I [COI] gene) were compared with all four potentially invasive Stegomyia species: St. aegypti, St. albopicta, St. cretina, and St. japonica. Sequences generated for samples collected in Thrace Region were herein confirmed as St. albopicta, the first record of this vector species in Turkey. Eggs of St. albopicta were detected in two discrete localities: (1) In the grounds of a restaurant in Kesan (in week 36), and (2) in the customs area of the Turkish-Greek border at Ipsala (in weeks 32 and 38). Multiple detection of St. albopicta eggs indicates the possible establishment of the species in northwestern Turkey. Finding this important disease vector has implications for public health and requires the implementation of active vector monitoring programs and targeted vector suppression strategies to limit the spread of this invasive vector species in Turkey. C1 [Oter, Kerem; Tuzer, Erkut] Istanbul Univ, Fac Vet Med, Dept Parasitol, Avcilar, Turkey. [Gunay, Filiz; Alten, Bulent] Hacettepe Univ, Fac Sci, Dept Biol, Ecol Div,ESRL Labs, Beytepe, Turkey. [Linton, Yvonne-Marie] Walter Reed Army Inst Res, Entomol Branch, Silver Spring, MD USA. [Bellini, Romeo] Ctr Agr Ambiente G Nicoli, Crevalcore, Italy. RP Linton, YM (reprint author), Smithsonian Inst, Walter Reed Biosystemat Unit, Museum Support Ctr, MSC 534,4210 Silver Hill Rd, Suitland, MD 20746 USA. EM linton.yvonne3@gmail.com FU Scientific Research Projects Coordination Unit of Istanbul University [11459]; Hacettepe University Scientific Research Unit, Ankara, Turkey; National Research Council (NRC) Research Associateship Award at the Walter Reed Army Institute of Research FX Funding for this study was provided by the Scientific Research Projects Coordination Unit of Istanbul University (Project Number 11459) and Hacettepe University Scientific Research Unit, Ankara, Turkey. DNA sequencing for this study was carried out as part of the activities of the Mosquito Barcoding Initiative (Project Leaders: Y.M.L. and Richard C. Wilkerson, Walter Reed Biosystematics Unit [WRBU], Smithsonian Institution, USA). We are grateful to MBI collaborators, Major Joshua Bast (USAMRU-Kenya) and Dr. G. Koliopoulos (Benaki Institute, Athens, Greece), for providing specimens used as outgroups in this study, and to Dr. Desmond Foley (WRBU) and Ssgt. Luke Mitchell (British Army) for assistance with the map figure. This manuscript was prepared while Y.M.L. held a National Research Council (NRC) Research Associateship Award at the Walter Reed Army Institute of Research. The material to be published reflects the views of the authors and should not be construed to represent those of the US Department of the Army or the US Department of Defense. NR 54 TC 8 Z9 9 U1 2 U2 4 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1530-3667 EI 1557-7759 J9 VECTOR-BORNE ZOONOT JI Vector-Borne Zoonotic Dis. PD OCT 1 PY 2013 VL 13 IS 10 BP 753 EP 761 DI 10.1089/vbz.2012.1093 PG 9 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA 230RO UT WOS:000325360300009 PM 23808976 ER PT J AU Loaiza, JR Scott, ME Bermingham, E Sanjur, OI Rovira, JR Dutari, LC Linton, YM Bickersmith, S Conn, JE AF Loaiza, Jose R. Scott, Marilyn E. Bermingham, Eldredge Sanjur, Oris I. Rovira, Jose R. Dutari, Larissa C. Linton, Yvonne-Marie Bickersmith, Sara Conn, Jan E. TI Novel genetic diversity within Anopheles punctimacula s.l.: Phylogenetic discrepancy between the Barcode cytochrome c oxidase I (COI) gene and the rDNA second internal transcribed spacer (ITS2) SO ACTA TROPICA LA English DT Article DE Anopheles punctimacula s.l.; Molecular taxonomy; Arribalzagia Series; COI gene; Folmer region; rDNA-ITS2 ID DIPTERA-CULICIDAE; MALARIA VECTORS; CENTRAL-AMERICA; SOUTHEAST-ASIA; DNA BARCODES; MOLECULAR-IDENTIFICATION; POPULATION DIVERGENCE; SUNDAICUS DIPTERA; SPECIES COMPLEX; RIBOSOMAL DNA AB Anopheles punctimacula s.l. is a regional malaria vector in parts of Central America, but its role in transmission is controversial due to its unresolved taxonomic status. Two cryptic species, An. malefactor and An. calderoni, have been previously confused with this taxon, and evidence for further genetic differentiation has been proposed. In the present study we collected and morphologically identified adult female mosquitoes of An. punctimacula s.l. from 10 localities across Panama and one in Costa Rica. DNA sequences from three molecular regions, the three prime end of the mitochondrial cytochrome c oxidase I gene (3' C01), the Barcode region in the five prime end of the COI (5' C01), and the rDNA second internal transcribed spacer (ITS2) were used to test the hypothesis of new molecular lineages within An. punctimacula s.l. Phylogenetic analyses using the 3' COI depicted six highly supported molecular lineages (A F), none of which was An. malefactor. In contrast, phylogenetic inference with the 5' COI demonstrated paraphyly. Tree topologies based on the combined COI regions and ITS2 sequence data supported the same six lineages as the 3' COI alone. As a whole this evidence suggests that An. punctimacula s.l. comprises two geographically isolated lineages, but it is not clear whether these are true species. The phylogenetic structure of the An. punctimacula cluster as well as that of other unknown lineages (C type I vs C type II; D vs E) appears to be driven by geographic partition, because members of these assemblages did not overlap spatially. We report An. malefactor for the first time in Costa Rica, but our data do not support the presence of An. calderoni in Panama. (C) 2013 Elsevier B.V. All rights reserved. C1 [Loaiza, Jose R.; Dutari, Larissa C.] Inst Invest Cient & Serv Alta Tecnol, Ctr Biodiversidad & Descubrimiento Drogas, Clayton, Panama. [Loaiza, Jose R.] Univ Panama, Programa Ctr Amer Maestria Entomol Vicerrectoria, Panama City, Panama. [Scott, Marilyn E.] McGill Univ, Inst Parasitol, Montreal, PQ H3A 2T5, Canada. [Bermingham, Eldredge; Sanjur, Oris I.; Rovira, Jose R.; Dutari, Larissa C.] Smithsonian Trop Res Inst, U0948, Balboa Ancon, Panama. [Linton, Yvonne-Marie] Nat Hist Museum, London SW7 5BD, England. [Linton, Yvonne-Marie] Walter Reed Army Inst Res, Entomol Branch, Silver Spring, MD 20910 USA. [Bickersmith, Sara; Conn, Jan E.] New York State Dept Hlth, Wadsworth Ctr, Albany, NY 12205 USA. [Conn, Jan E.] SUNY Albany, Dept Biomed Sci, Albany, NY 12202 USA. RP Loaiza, JR (reprint author), Inst Invest Cient & Serv Alta Tecnol, Ctr Biodiversidad & Descubrimiento Drogas, Clayton, Panama. EM jloaiza@indicasat.org.pa; marilyn.scott@mcgill.ca; bermingham@si.edu; sanjuro@si.edu; jrrovira@yahoo.es; dutaril@si.edu; linton.yvonne3@gmail.com; sab19@health.state.ny.us; jconn@wadsworth.org RI Scott, Marilyn/L-5347-2015; OI Conn, Jan/0000-0002-5301-7020 FU Science, Technology and Innovation of Panama (SENACYT) [COL08-066]; National Research Investigator Board; Institute of Advanced Scientific Investigations and High Technology Services (INDICASAT AIP); Smithsonian Tropical Research Institute (STRI); Natural Sciences and Engineering Research Council of Canada (NSERC); NIH [2R0154139]; Fonds Quebecois de la recherche sur la nature et les technologies (FQRNT); Walter Reed Army Institute of Research FX We want to thank three anonymous reviewers who provided valuable comments to improve the quality, clarity and impact of this manuscript. We also thank Dr. Marta Moreno (Wadsworth Center, New York State Department of Health, Albany, NY) and Sasha McKeon (Department of Biomedical Sciences, School of Public Health, SUNY-Albany, NY) for assistance with analysis and experiments. We are grateful to Luis Guillermo Chaverri Sanchez and Alvaro Herrera Villalobos from the Instituto Nacional de Biodiversidad de Costa Rica (INBio) for helping us obtain the required collecting and export permits and for fieldwork guidance in Costa Rica. Mosquito sampling in Costa Rica was conducted under the research passport (No. 01573/resolution 096-2007) issued to JRL by the National System of Conservation Areas (SINAC). The export permit (DGVS-867-2007) was granted by the Ministry of Natural Resources, Energy, and Mines (MIRENEM). The Secretariat for Science, Technology and Innovation of Panama (SENACYT) through the research grant COL08-066 and the National Research Investigator Board (SNI) prize awarded to JRL, partially financed this study. Additional financial support was provided by The Institute of Advanced Scientific Investigations and High Technology Services (INDICASAT AIP), the Smithsonian Tropical Research Institute (STRI), Natural Sciences and Engineering Research Council of Canada (NSERC) and NIH grant (AI) 2R0154139 to JEC. Research at the Institute of Parasitology is supported by a regroupement strategique from Fonds Quebecois de la recherche sur la nature et les technologies (FQRNT) to MES. This manuscript was prepared while YML held a National Research Council (NRC) Research Associateship Award at the Walter Reed Army Institute of Research. The material to be published reflects the views of the authors and should not be construed to represent those of the US Department of the Army or the US Department of Defense. NR 52 TC 8 Z9 9 U1 2 U2 16 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0001-706X EI 1873-6254 J9 ACTA TROP JI Acta Trop. PD OCT PY 2013 VL 128 IS 1 BP 61 EP 69 DI 10.1016/j.actatropica.2018.06.012 PG 9 WC Parasitology; Tropical Medicine SC Parasitology; Tropical Medicine GA 239GA UT WOS:000326009400009 PM 23806568 ER PT J AU del Rincon, I Haas, RW Restrepo, JF Battafarano, DF O'Leary, DH Molina, E Escalante, A AF del Rincon, Inmaculada Haas, Roy W. Restrepo, Jose Felix Battafarano, Daniel F. O'Leary, Daniel H. Molina, Emily Escalante, Agustin TI Carotid Atherosclerosis As a Predictor Of Mortality In Rheumatoid Arthritis. SO ARTHRITIS AND RHEUMATISM LA English DT Meeting Abstract CT 77th Annual Meeting of the American-College-of-Rheumatology / 48th Annual Meeting of the Association-of-Rheumatology-Health-Professionals CY OCT 25-30, 2013 CL San Diego, CA SP Amer Coll Rheumatol, Assoc Rheumatol Hlth Profess C1 [del Rincon, Inmaculada; Haas, Roy W.; Restrepo, Jose Felix; Escalante, Agustin] Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA. [Battafarano, Daniel F.] Brooke Army Med Ctr, San Antonio, TX USA. [O'Leary, Daniel H.] Tufts Univ, Boston, MA 02111 USA. [Molina, Emily] Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0004-3591 EI 1529-0131 J9 ARTHRITIS RHEUM-US JI Arthritis Rheum. PD OCT PY 2013 VL 65 SU 10 SI SI MA 2763 BP S1180 EP S1181 PG 2 WC Rheumatology SC Rheumatology GA 230RF UT WOS:000325359206192 ER PT J AU Barcia, AM Rowles, DJ Bottoni, CR Dekker, TJ Tokish, JM AF Barcia, Anthony M. Rowles, Douglas J. Bottoni, Craig R. Dekker, Travis J. Tokish, John M. TI Glenoid Bare Area: Arthroscopic Characterization and Its Implications on Measurement of Bone Loss SO ARTHROSCOPY-THE JOURNAL OF ARTHROSCOPIC AND RELATED SURGERY LA English DT Article ID SHOULDER INSTABILITY; SPOT; LANDMARK; JOINT AB Purpose: The purpose of this study was to characterize arthroscopically the frequency and location of the glenoid bare area. Methods: Three fellowship-trained orthopaedic sports surgeons evaluated and characterized the bare area of the glenoid in 52 consecutive patients undergoing arthroscopic surgery of the shoulder without a diagnosis of instability. Among the patients with a visible bare area, the position was measured, and when eccentrically located, an apparent bone loss or gain was calculated. Results: The bare area of the glenoid was observed in only 48% of patients undergoing arthroscopic surgery, and when observed, it was at the center only 37% of the time. Of the glenoids with visible bare areas, 8% were located anteriorly enough to result in an apparent bone loss calculation of greater than 20%. An additional 25% of visible bare areas were posteriorly located, resulting in an apparent bone gain. Conclusions: The glenoid bare area is a variably visible and eccentric landmark on the glenoid and thus should not be used as the sole reference point to measure glenoid bone loss. Level of Evidence: Level IV, retrospective observational study. C1 [Barcia, Anthony M.; Rowles, Douglas J.; Bottoni, Craig R.; Tokish, John M.] Tripler Army Med Ctr, Honolulu, HI 96859 USA. [Dekker, Travis J.] Georgetown Sch Med, Washington, DC USA. RP Barcia, AM (reprint author), Tripler Army Med Ctr, Dept Orthopaed Surg, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM tbarcia@gmail.com FU Arthrex; Musculoskeletal Transplant Foundation FX The authors report the following potential conflict of interest or source of funding: C.R.B. receives support from Arthrex, Musculoskeletal Transplant Foundation. Unrestricted research grants. NR 17 TC 1 Z9 1 U1 0 U2 1 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0749-8063 EI 1526-3231 J9 ARTHROSCOPY JI Arthroscopy PD OCT PY 2013 VL 29 IS 10 BP 1671 EP 1675 DI 10.1016/j.arthro.2013.06.019 PG 5 WC Orthopedics; Surgery SC Orthopedics; Surgery GA 227AG UT WOS:000325078800017 PM 23993146 ER PT J AU Garcia-Reyero, N Martyniuk, CJ Kroll, KJ Escalon, BL Spade, DJ Denslow, ND AF Garcia-Reyero, Natalia Martyniuk, Christopher J. Kroll, Kevin J. Escalon, B. Lynn Spade, Daniel J. Denslow, Nancy D. TI Transcriptional signature of progesterone in the fathead minnow ovary (Pimephales promelas) SO GENERAL AND COMPARATIVE ENDOCRINOLOGY LA English DT Article DE Microarrays; Calcium signaling; Germinal vesicle breakdown; Ribosomes; Progestins ID MATURATION-INDUCING HORMONE; GERMINAL VESICLE BREAKDOWN; TROUT ONCORHYNCHUS-MYKISS; FINAL OOCYTE MATURATION; PROTEIN-KINASE-B; GROWTH-FACTOR-I; MEIOTIC MATURATION; GENE-EXPRESSION; FOLLICLES PRIOR; MOUSE OOCYTES AB A growing number of studies have examined transcriptional responses to sex steroids along the hypothalamic-pituitary-gonadal axis in teleost fishes. However, data are lacking on the molecular cascades that underlie progesterone signaling. The objective of this study was to characterize the transcriptional response in the ovary of fat-head minnows (Pimephales promelas) in response to progesterone (P4). Fathead minnow ovaries were exposed in vitro to 500 ng P4/L. Germinal vesicle migration and breakdown (GVBD) was observed and microarrays were used to identify gene cascades affected by P4. Microarray analysis identified 1702 differentially expressed transcripts after P4 treatment. Functional enrichment analysis revealed that transcripts involved in the molecular functions of protein serine/threonine kinase activity, ATP binding, and activity of calcium channels were increased after P4 treatment. There was an overwhelming decrease in levels of transcripts of genes that are structural constituents of ribosomes with P4 treatment. There was also evidence for gene expression changes in steroid and maturation-related transcripts. Pathway analyses identified cell cycle regulation, insulin action, hedgehog, and B cell activation as pathways containing an over-representation of highly regulated transcripts. Significant regulatory sub-networks of P4-mediated transcripts included genes regulated by tumor protein p53 and E2F transcription factor I. These data provide novel insight into the molecular signaling cascades that underlie P4-signaling in the ovary and identify genes and processes that may indicate premature GVBD due to environmental pollutants that mimic progestins. (C) 2013 Published by Elsevier Inc. C1 [Garcia-Reyero, Natalia] Mississippi State Univ, Inst Genom Biocomp & Biotechnol, Starkville, MS 39759 USA. [Martyniuk, Christopher J.] Univ New Brunswick, Dept Biol, Canadian Rivers Inst, St John, NB E2L 4L5, Canada. [Kroll, Kevin J.; Spade, Daniel J.; Denslow, Nancy D.] Univ Florida, Dept Physiol Sci, Ctr Environm & Human Toxicol, Gainesville, FL 32611 USA. [Escalon, B. Lynn] USA, Environm Lab, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Denslow, ND (reprint author), Univ Florida, Dept Physiol Sci, Ctr Environm & Human Toxicol, POB 110885, Gainesville, FL 32611 USA. EM ndenslow@ufl.edu FU National Institute of Environmental Health Sciences [P42 ES 07375]; Canadian Research Chair Program; Natural Sciences and Engineering Research Council (NSERC) Discovery Grant; US Army Environmental Quality Research Program [BAA 11-4838] FX We thank D.G. Ostrow at the Interdisciplinary Center for Biotechnology Research ICBR at UF for microarray processing and data extraction. This research was funded by a Superfund Basic Research Program from the National Institute of Environmental Health Sciences, P42 ES 07375 (NDD), and by the Canadian Research Chair Program (CJM) and a Natural Sciences and Engineering Research Council (NSERC) Discovery Grant (CJM). This work was also partially funded by the US Army Environmental Quality Research Program (including BAA 11-4838). Permission for publishing this information has been granted by the Chief of Engineers. The authors have no competing financial or non-financial interests to declare. NR 64 TC 10 Z9 10 U1 1 U2 23 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0016-6480 EI 1095-6840 J9 GEN COMP ENDOCR JI Gen. Comp. Endocrinol. PD OCT 1 PY 2013 VL 192 BP 159 EP 169 DI 10.1016/j.ygcen.2013.06.008 PG 11 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA 235QS UT WOS:000325736400019 PM 23796460 ER PT J AU Everitt, JH Yang, CH Summy, K Nachtrieb, JG AF Everitt, James H. Yang, Chenghai Summy, Kenneth Nachtrieb, Julie G. TI Using hyperspectral reflectance data to assess biocontrol damage of giant salvinia SO GEOCARTO INTERNATIONAL LA English DT Article DE spectral signature; Salvinia molesta; stepwise discriminant analysis; least significant difference; biological control; hyperspectral reflectance; Crtobagous salviniae ID BIOLOGICAL-CONTROL; CYRTOBAGOUS-SALVINIAE; MOLESTA; VEGETATION; CURCULIONIDAE; COLEOPTERA; TEXAS; WEED AB Field hyperspectral reflectance data were studied at 50 wavebands (10-nm bandwidth) over the 400- to 900-nm spectral range to determine their potential for distinguishing among giant salvinia (Salvinia molesta Mitchell) plants subjected to four population levels of salvinia weevils (Cyrtobagous salviniae Calder and Sands) to develop feeding damage to the plants. The four populations included a control with no insects and those with low, medium and high insect populations. The plants were studied in two experiments on each of two dates: 14 October 2010 and 21 July 2011. Two procedures were used to determine the optimum bands for discriminating among treatments: least significant difference (LSD) and stepwise discriminant analysis. The LSD comparison test results for both October and July experiments showed that generally the best bands for separating among treatments occurred in the green (505-595 nm), red (605-635 nm), red-near-infrared (NIR; 695-745 nm) edge and NIR (755-895 nm) regions where three to four treatments could be distinguished. Stepwise discriminant analysis identified four bands in the green, red and red-NIR edge to be significant to discriminate among the four treatments in Experiment 1 in October. For Experiment 2 in October, discriminant analysis identified five bands in the blue, green, red and NIR regions to be significant for distinguishing among the treatments. In Experiment 1 in July, five bands in the blue, green, red-NIR edge and NIR regions were found to be significant to discriminate among the treatments. For Experiment 2 in July, discriminant analysis identified four bands in the blue, green and red-NIR edge regions to be significant to discriminate among the treatments. C1 [Everitt, James H.] USDA ARS, Weslaco, TX 78596 USA. [Yang, Chenghai] USDA ARS, College Stn, TX 77845 USA. [Summy, Kenneth] Univ Texas Pan Amer, Dept Biol, Edinburg, TX 78541 USA. [Nachtrieb, Julie G.] US Army Corp Engn Res, Lewisville, TX 75057 USA. RP Yang, CH (reprint author), USDA ARS, 2771 F&B Rd, College Stn, TX 77845 USA. EM chenghai.yang@ars.usda.gov NR 40 TC 1 Z9 1 U1 0 U2 13 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 1010-6049 EI 1752-0762 J9 GEOCARTO INT JI Geocarto Int. PD OCT 1 PY 2013 VL 28 IS 6 BP 502 EP 516 DI 10.1080/10106049.2012.724454 PG 15 WC Environmental Sciences; Geosciences, Multidisciplinary; Remote Sensing; Imaging Science & Photographic Technology SC Environmental Sciences & Ecology; Geology; Remote Sensing; Imaging Science & Photographic Technology GA 218AA UT WOS:000324403700003 ER PT J AU Sadler, BM Rus, D Sukhatme, GS AF Sadler, Brian M. Rus, Daniela Sukhatme, Gaurav S. TI Special Issue on Robotic Communications and Collaboration in Complex Environments SO INTERNATIONAL JOURNAL OF ROBOTICS RESEARCH LA English DT Editorial Material C1 [Sadler, Brian M.] Army Res Lab, Adelphi, MD 20783 USA. [Rus, Daniela] MIT, Cambridge, MA 02139 USA. [Sukhatme, Gaurav S.] Univ So Calif, Los Angeles, CA 90089 USA. RP Sadler, BM (reprint author), Army Res Lab, Adelphi, MD 20783 USA. NR 0 TC 1 Z9 1 U1 0 U2 4 PU SAGE PUBLICATIONS LTD PI LONDON PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND SN 0278-3649 EI 1741-3176 J9 INT J ROBOT RES JI Int. J. Robot. Res. PD OCT PY 2013 VL 32 IS 12 SI SI BP 1361 EP 1362 DI 10.1177/0278364913505046 PG 2 WC Robotics SC Robotics GA 243AU UT WOS:000326289500001 ER PT J AU Twigg, JN Fink, JR Yu, PL Sadler, BM AF Twigg, Jeffrey N. Fink, Jonathan R. Yu, Paul L. Sadler, Brian M. TI Efficient base station connectivity area discovery SO INTERNATIONAL JOURNAL OF ROBOTICS RESEARCH LA English DT Article DE communication maintenance; networked robotics; environment sampling; channel estimation; map decomposition AB Many applications of autonomy are significantly complicated by the need for wireless networking, with challenges including scalability and robustness. Radio accomplishes this in a complex environment, but suffers from rapid signal strength variation and attenuation typically much worse than free space loss. In this paper, we propose and test algorithms to autonomously discover the connectivity area for a base station in an unknown environment using an average of received signal strength (RSS) values and a RSS threshold to delineate the goodness of the channel. We combine region decomposition and RSS sampling to cast the problem as an efficient graph search. The nominal RSS in a sampling region is obtained by averaging local RSS samples to reduce the small-scale fading variation. The RSS gradient is exploited during exploration to develop an efficient approach for discovery of the base station connectivity boundary in an unknown environment. Indoor and outdoor experiments demonstrate the proposed techniques. The results can be used for sensing and collaborative autonomy, building base station coverage maps in unknown environments, and facilitating multi-hop relaying to a base station. C1 [Twigg, Jeffrey N.; Fink, Jonathan R.; Yu, Paul L.; Sadler, Brian M.] US Army Res Lab, Adelphi, MD 20783 USA. RP Fink, JR (reprint author), US Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM jonathan.r.fink3.civ@mail.mil NR 17 TC 5 Z9 5 U1 0 U2 5 PU SAGE PUBLICATIONS LTD PI LONDON PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND SN 0278-3649 EI 1741-3176 J9 INT J ROBOT RES JI Int. J. Robot. Res. PD OCT PY 2013 VL 32 IS 12 SI SI BP 1398 EP 1410 DI 10.1177/0278364913488634 PG 13 WC Robotics SC Robotics GA 243AU UT WOS:000326289500004 ER PT J AU Allen, JB Cornwell, CF Devine, BD Welch, CR AF Allen, J. B. Cornwell, C. F. Devine, B. D. Welch, C. R. TI Simulations of Anisotropic Grain Growth Subject to Thermal Gradients Using Q-State Monte Carlo SO JOURNAL OF ENGINEERING MATERIALS AND TECHNOLOGY-TRANSACTIONS OF THE ASME LA English DT Article ID COMPUTER-SIMULATION; NANOCRYSTALLINE MATERIALS; BOUNDARY MOBILITY; POTTS-MODEL; MICROSTRUCTURE; EVOLUTION; COATINGS; KINETICS; PHASE AB The Q-state Monte Carlo, Potts model is used to investigate 2D, anisotropic, grain growth of single-phase materials subject to temperature gradients. Anisotropy is simulated via the use of nonuniform grain boundary surface energies, and thermal gradients are simulated through the use of variable grain boundary mobilities. Hexagonal grain elements are employed, and elliptical Wulff plots are used to assign surface energies to grain lattices. The mobility is set to vary in accordance with solutions to a generalized heat equation and is solved for two separate values of the mobility coefficient. Among other findings, the results reveal that like isotropic grain growth, under the influence of a thermal gradient, anisotropic grain growth also demonstrates locally normal growth kinetics. C1 [Allen, J. B.; Cornwell, C. F.; Devine, B. D.; Welch, C. R.] US Army, Informat Technol Lab, Engn Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Allen, JB (reprint author), US Army, Informat Technol Lab, Engn Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM Jeffrey.B.Allen@erdc.dren.mil FU research program: "Nanoscale Studies of Polycrystalline Materials with Emphasis on Ceramic Synthesis"; research program: "Effects of Grain Boundaries on Ceramic Properties" FX This research was performed as part of the U.S. Army Engineer Research and Development Center's Advanced Material Initiative. In particular, the authors gratefully acknowledge the funding support from the research programs: "Nanoscale Studies of Polycrystalline Materials with Emphasis on Ceramic Synthesis" and "Effects of Grain Boundaries on Ceramic Properties." We thank the Chief of Engineers of the U.S. Army Corps of Engineers for permission to publish this article. NR 34 TC 3 Z9 3 U1 1 U2 9 PU ASME PI NEW YORK PA TWO PARK AVE, NEW YORK, NY 10016-5990 USA SN 0094-4289 EI 1528-8889 J9 J ENG MATER-T ASME JI J. Eng. Mater. Technol.-Trans. ASME PD OCT PY 2013 VL 135 IS 4 AR 041005 DI 10.1115/1.4025171 PG 9 WC Engineering, Mechanical; Materials Science, Multidisciplinary SC Engineering; Materials Science GA 241ST UT WOS:000326188700005 ER PT J AU Allison, PG Grewal, H Hammi, Y Brown, HR Whittington, WR Horstemeyer, MF AF Allison, P. G. Grewal, H. Hammi, Y. Brown, H. R. Whittington, W. R. Horstemeyer, M. F. TI Plasticity and Fracture Modeling/Experimental Study of a Porous Metal Under Various Strain Rates, Temperatures, and Stress States SO JOURNAL OF ENGINEERING MATERIALS AND TECHNOLOGY-TRANSACTIONS OF THE ASME LA English DT Article ID DUCTILE METALS; VOID GROWTH; MODEL; VISCOPLASTICITY AB A microstructure-based internal state variable (ISV) plasticity-damage model was used to model the mechanical behavior of a porous FC-0205 steel alloy that was procured via a powder metal (PM) process. Because the porosity was very high and the nearest neighbor distance (NND) for the pores was close, a new pore coalescence ISV equation was introduced that allows for enhanced pore growth from the concentrated pores. This coalescence equation effectively includes the local stress interaction within the interpore ligament distance between pores and is physically motivated with these highly porous powder metals. Monotonic tension, compression, and torsion tests were performed at various porosity levels and temperatures to obtain the set of plasticity and damage constants required for model calibration. Once the model calibration was achieved, then tension tests on two different notch radii Bridgman specimens were undertaken to study the damage-triaxiality dependence for model validation. Fracture surface analysis was performed using scanning electron microscopy (SEM) to quantify the pore sizes of the different specimens. The validated model was then used to predict the component performance of an automotive PM bearing cap. Although the microstructure-sensitive ISV model has been employed for this particular FC-0205 steel, the model is general enough to be applied to other metal alloys as well. C1 [Allison, P. G.] US Army, ERDC, Vicksburg, MS 39081 USA. [Allison, P. G.; Grewal, H.; Brown, H. R.; Whittington, W. R.; Horstemeyer, M. F.] Mississippi State Univ, Dept Mech Engn, Mississippi State, MS 39762 USA. [Hammi, Y.] Mississippi State Univ, CAVS, Mississippi State, MS 39762 USA. RP Allison, PG (reprint author), US Army, ERDC, Vicksburg, MS 39081 USA. OI Allison, Paul/0000-0002-9041-237X; Horstemeyer, Mark/0000-0003-4230-0063 FU U.S. Automotive Materials Partnership (AMD410) [FC-26-02OR22910]; Center for Advanced Vehicular Systems (CAVS) at Mississippi State University FX This research was funded by U.S. Automotive Materials Partnership (AMD410) contract no. FC-26-02OR22910 with guidance from Howard I. Sanderow (Center for Powder Metallurgy Technology-CPMT), Russell A. Chernenkoff (Metaldyne), Paulo Rosa (DaimlerChrysler), Shekhar G. Wakade (GM Powertrain), and Glen Weber (Ford Motor Company). We would also like to acknowledge the Center for Advanced Vehicular Systems (CAVS) at Mississippi State University for supporting this work. NR 25 TC 0 Z9 0 U1 1 U2 9 PU ASME PI NEW YORK PA TWO PARK AVE, NEW YORK, NY 10016-5990 USA SN 0094-4289 EI 1528-8889 J9 J ENG MATER-T ASME JI J. Eng. Mater. Technol.-Trans. ASME PD OCT PY 2013 VL 135 IS 4 AR 041008 DI 10.1115/1.4025292 PG 13 WC Engineering, Mechanical; Materials Science, Multidisciplinary SC Engineering; Materials Science GA 241ST UT WOS:000326188700008 ER PT J AU Phadikar, JK Bogetti, TA Kaliakin, VN Karlsson, AM AF Phadikar, J. K. Bogetti, T. A. Kaliakin, V. N. Karlsson, A. M. TI Conical Indentation of a Viscoelastic Sphere SO JOURNAL OF ENGINEERING MATERIALS AND TECHNOLOGY-TRANSACTIONS OF THE ASME LA English DT Article ID PLASTIC PROPERTIES; STRESS AB Instrumented indentation is commonly used for determining mechanical properties of a range of materials, including viscoelastic materials. However, most-if not all-studies are limited to a flat substrate being indented by various shaped indenters (e. g., conical or spherical). This work investigates the possibility of extending instrumented indentation to nonflat viscoelastic substrates. In particular, conical indentation of a sphere is investigated where a semi-analytical approach based on "the method of functional equations" has been developed to obtain the force-displacement relationship. To verify the accuracy of the proposed methodology selected numerical experiments have been performed and good agreement was obtained. Since it takes significantly less time to obtain force-displacement relationships using the proposed method compared to conducting full finite element simulations, the proposed method is an efficient substitute of the finite element method in determining material properties of viscoelatic spherical particles using indentation testing. C1 [Phadikar, J. K.; Karlsson, A. M.] Univ Delaware, Dept Mech Engn, Newark, DE 19716 USA. [Bogetti, T. A.] US Army, Res Lab, Aberdeen Proving Ground, MD 21001 USA. [Kaliakin, V. N.] Univ Delaware, Dept Civil & Environm Engn, Newark, DE 19716 USA. [Karlsson, A. M.] Cleveland State Univ, Fenn Coll Engn, Cleveland, OH 44115 USA. RP Karlsson, AM (reprint author), Univ Delaware, Dept Mech Engn, Newark, DE 19716 USA. EM a.karlsson@csuohio.edu NR 20 TC 1 Z9 1 U1 0 U2 10 PU ASME PI NEW YORK PA TWO PARK AVE, NEW YORK, NY 10016-5990 USA SN 0094-4289 EI 1528-8889 J9 J ENG MATER-T ASME JI J. Eng. Mater. Technol.-Trans. ASME PD OCT PY 2013 VL 135 IS 4 AR 041001 DI 10.1115/1.4024395 PG 5 WC Engineering, Mechanical; Materials Science, Multidisciplinary SC Engineering; Materials Science GA 241ST UT WOS:000326188700001 ER PT J AU Lesho, E Yoon, EJ McGann, P Snesrud, E Kwak, Y Milillo, M Onmus-Leone, F Preston, L St Clair, K Nikolich, M Viscount, H Wortmann, G Zapor, M Grillot-Courvalin, C Courvalin, P Clifford, R Waterman, PE AF Lesho, Emil Yoon, Eun-Jeong McGann, Patrick Snesrud, Erik Kwak, Yoon Milillo, Michael Onmus-Leone, Fatma Preston, Lan St Clair, Kristina Nikolich, Mikeljon Viscount, Helen Wortmann, Glenn Zapor, Michael Grillot-Courvalin, Catherine Courvalin, Patrice Clifford, Robert Waterman, Paige E. TI Emergence of Colistin-Resistance in Extremely Drug-Resistant Acinetobacter baumannii Containing a Novel pmrCAB Operon During Colistin Therapy of Wound Infections SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article DE Colistin-resistant Acinetobacter baumannii; infection control; translational research ID PHOSPHOETHANOLAMINE MODIFICATION; VANCOMYCIN RESISTANCE; IMPAIRED VIRULENCE; FITNESS COST; POLYMYXIN-B; SEQUENCE; LIPOPOLYSACCHARIDE; EPIDEMIOLOGY; SYSTEM; PCR AB Background. Colistin resistance is of concern since it is increasingly needed to treat infections caused by bacteria resistant to all other antibiotics and has been associated with poorer outcomes. Longitudinal data from in vivo series are sparse. Methods. Under a quality-improvement directive to intensify infection-control measures, extremely drug-resistant (XDR) bacteria undergo phenotypic and molecular analysis. Results. Twenty-eight XDR Acinetobacter baumannii isolates were longitudinally recovered during colistin therapy. Fourteen were susceptible to colistin, and 14 were resistant to colistin. Acquisition of colistin resistance did not alter resistance to other antibiotics. Isolates had low minimum inhibitory concentrations of an investigational aminoglycoside, belonged to multi-locus sequence type 94, were indistinguishable by pulsed-field gel electrophoresis and optical mapping, and harbored a novel pmrC1A1B allele. Colistin resistance was associated with point mutations in the pmrA1 and/or pmrB genes. Additional pmrC homologs, designated eptA-1 and eptA-2, were at distant locations from the operon. Compared with colistin-susceptible isolates, colistin-resistant isolates displayed significantly enhanced expression of pmrC1A1B, eptA-1, and eptA-2; lower growth rates; and lowered fitness. Phylogenetic analysis suggested that colistin resistance emerged from a single progenitor colistin-susceptible isolate. Conclusions. We provide insights into the in vivo evolution of colistin resistance in a series of XDR A. baumannii isolates recovered during therapy of infections and emphasize the importance of antibiotic stewardship and surveillance. C1 [Lesho, Emil; McGann, Patrick; Snesrud, Erik; Kwak, Yoon; Milillo, Michael; Onmus-Leone, Fatma; Preston, Lan; Clifford, Robert; Waterman, Paige E.] Walter Reed Army Inst Res, Multidrug Resistant Organism Repository & Surveil, Silver Spring, MD USA. [Nikolich, Mikeljon] Walter Reed Army Inst Res, Dept Emerging Bacterial Infect, Silver Spring, MD USA. [St Clair, Kristina; Wortmann, Glenn; Zapor, Michael] Walter Reed Natl Mil Med Ctr, Infect Dis Serv, Bethesda, MD USA. [Viscount, Helen] Walter Reed Natl Mil Med Ctr, Dept Pathol, Bethesda, MD USA. [Grillot-Courvalin, Catherine; Courvalin, Patrice] Inst Pasteur, Unite Agents Antibacteriens, Paris, France. RP Lesho, E (reprint author), 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM emil.lesho@us.army.mil FU US Army Medical Command; Armed Forces Health Surveillance Center's Global Emerging Infections Surveillance and Response System; Defense Medical Research and Development Program; European Union [FP7-PAR] FX This work was supported by the US Army Medical Command, the Armed Forces Health Surveillance Center's Global Emerging Infections Surveillance and Response System, the Defense Medical Research and Development Program, and the European Union (grant FP7-PAR to E. J. Y.). NR 33 TC 40 Z9 43 U1 0 U2 6 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0022-1899 EI 1537-6613 J9 J INFECT DIS JI J. Infect. Dis. PD OCT 1 PY 2013 VL 208 IS 7 BP 1142 EP 1151 DI 10.1093/infdis/jit293 PG 10 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 239ST UT WOS:000326046400013 PM 23812239 ER PT J AU Tabatabaei, ZS Volz, JS Gliha, BP Keener, DI AF Tabatabaei, Zahra S. Volz, Jeffery S. Gliha, Benjamin P. Keener, Darwin I. TI Development of Long Carbon Fiber-Reinforced Concrete for Dynamic Strengthening SO JOURNAL OF MATERIALS IN CIVIL ENGINEERING LA English DT Article DE Fibers; Carbon; Reinforced concrete; Dynamic loads; Fibers; Carbon; Reinforced concrete; Dynamic loads ID IMPACT AB This paper discusses the development and testing of long carbon fibers-fibers 75 mm long or longer-to improve the resistance of reinforced concrete to dynamic loading, such as blasts and impact. In the past, attempts to use long fibers in concrete have failed as a result of both balling (agglomeration) and poor dispersion of the fibers. In the present study, two types of long carbon fibers were developed and optimized for their use in reinforced concrete. The resulting long carbon fiber-reinforced concrete (LCFRC) was subsequently evaluated through impact and blast testing. Full-scale blast testing revealed that these fibers significantly increased the resistance of concrete spalling. In terms of the amount of material lost during the blast, LCFRC panels outperformed nonfiber concrete panels by nearly a factor of 10. This significant reduction in weight loss for the LCFRC panels translates into a substantial decrease in harmful, flying debris in a blast event, and a corresponding reduction in blast lethality. C1 [Tabatabaei, Zahra S.; Volz, Jeffery S.] Missouri Univ Sci & Technol, Civil Architectural & Environm Engn Dept, Rolla, MO 65409 USA. [Gliha, Benjamin P.] US Army Corps Engn, Little Rock, AR 72203 USA. [Keener, Darwin I.] Properma Engn Coatings, Rolla, MO 65401 USA. RP Tabatabaei, ZS (reprint author), Missouri Univ Sci & Technol, Civil Architectural & Environm Engn Dept, 219 Butler Carlton Hall,1401 N Pine St, Rolla, MO 65409 USA. EM ztwx3@mail.mst.edu; volzj@mst.edu; Benjamin.p.Gliha@usace.army.mil; dkeener@pro-perma.com FU U.S. Army Research Lab (ARL); Leonard Wood Institute (LWI) [W911NF-07-2-0062, LWI-191-028] FX The authors gratefully acknowledge the financial support provided by both the U.S. Army Research Lab (ARL) and the Leonard Wood Institute (LWI) under Award Nos. W911NF-07-2-0062 and LWI-191-028, respectively. The conclusions and opinions expressed in this paper are those of the authors and do not necessarily reflect the official views or policies of either ARL or LWI. The authors are also grateful for the ideas and assistance of Drs. Eric Musselman and Andrea Schokker, University of Minnesota Duluth, and Mr. Michael Koenigstein, Pro-Perma Engineered Coatings. NR 14 TC 5 Z9 5 U1 0 U2 17 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 0899-1561 EI 1943-5533 J9 J MATER CIVIL ENG JI J. Mater. Civ. Eng. PD OCT 1 PY 2013 VL 25 IS 10 BP 1446 EP 1455 DI 10.1061/(ASCE)MT.1943-5533.0000692 PG 10 WC Construction & Building Technology; Engineering, Civil; Materials Science, Multidisciplinary SC Construction & Building Technology; Engineering; Materials Science GA 218XK UT WOS:000324465800011 ER PT J AU Ren, F Wang, JJA DiPaolo, BP AF Ren, Fei Wang, John Jy-An DiPaolo, Beverly P. TI Thermal Expansion Study and Microstructural Characterization of High-Performance Concretes SO JOURNAL OF MATERIALS IN CIVIL ENGINEERING LA English DT Article DE High-strength concrete; Thermal factors; Microstructures; High-performance concrete; Thermal analysis; Microstructure; SEM AB Ultra-high performance concrete (UHPC) is a family of emerging materials for building and construction applications. Behavior of UHPCs at high temperature is very important to their reliability and safety. In the current study, two UHPC materials were studied using the thermomechanical analysis (TMA) technique between room temperature and 800 degrees C. Both reversible and irreversible phase transformations were observed from the TMA results, which were likely attributable to the alpha-beta quartz transformation and the dehydroxylation transitions, respectively. Thermal expansion coefficients exhibited significant variations in different temperature regimes. Postmortem scanning electron microscopy (SEM) examinations revealed extensive cracking in the heated samples. In addition, microporosities were observed in the calcium-silicate-hydrate (C-S-H) phase as a result of phase changes during heating. C1 [Ren, Fei; Wang, John Jy-An] Oak Ridge Natl Lab, Mat Sci & Technol Div, Oak Ridge, TN 37831 USA. [DiPaolo, Beverly P.] US Army Corps Engineers, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Ren, F (reprint author), Oak Ridge Natl Lab, Mat Sci & Technol Div, Oak Ridge, TN 37831 USA. EM renf@ornl.gov OI Wang, Jy-An/0000-0003-2402-3832 FU Oak Ridge National Laboratory [DE-AC05-00OR22725]; Department of Homeland Security, Science and Technology Directorate, Infrastructure Protection and Disaster Management Division; U.S. Department of Energy, Office of Energy Efficiency and Renewable Energy, Vehicle Technologies Program FX This research was carried out at the Oak Ridge National Laboratory under contract DE-AC05-00OR22725 with UT-Battelle, LLC. This work was sponsored by the Department of Homeland Security, Science and Technology Directorate, Infrastructure Protection and Disaster Management Division: Ms. Mila Kennett, Program Manager. Permission to publish was granted by the Director, Geotechnical and Structures Laboratory, ERDC. Approved for public release; distribution is unlimited. The characterization equipment used in this study was managed by the HTML User Program, sponsored by the U.S. Department of Energy, Office of Energy Efficiency and Renewable Energy, Vehicle Technologies Program. NR 15 TC 0 Z9 0 U1 2 U2 20 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 0899-1561 EI 1943-5533 J9 J MATER CIVIL ENG JI J. Mater. Civ. Eng. PD OCT 1 PY 2013 VL 25 IS 10 BP 1574 EP 1578 DI 10.1061/(ASCE)MT.1943-5533.0000693 PG 5 WC Construction & Building Technology; Engineering, Civil; Materials Science, Multidisciplinary SC Construction & Building Technology; Engineering; Materials Science GA 218XK UT WOS:000324465800026 ER PT J AU Washburn, BE Cisar, PJ DeVault, TL AF Washburn, Brian E. Cisar, Paul J. DeVault, Travis L. TI Wildlife strikes to civil helicopters in the US, 1990-2011 SO TRANSPORTATION RESEARCH PART D-TRANSPORT AND ENVIRONMENT LA English DT Article DE Airfields; Aviation accidents; Helicopter; Wildlife strikes ID AIRCRAFT; RANKING AB This paper examines wildlife strikes with civil helicopters within the US. Month and time of day, location, and other factors influenced the frequency of wildlife strikes with civil helicopters. Wildlife strikes occurred most frequently when the aircraft were traveling en route or engaged in terrain flight. Birds accounted for over 97% of the wildlife strikes where the animal was identified. Published by Elsevier Ltd. C1 [Washburn, Brian E.; DeVault, Travis L.] Anim Plant Hlth Inspect Serv, USDA, Wildlife Serv, Natl Wildlife Res Ctr, Sandusky, OH 44870 USA. [Cisar, Paul J.] US Army, Logist Div, Aberdeen Test Ctr, Aberdeen Proving Ground, MD 21005 USA. RP Washburn, BE (reprint author), Anim Plant Hlth Inspect Serv, USDA, Wildlife Serv, Natl Wildlife Res Ctr, 6100 Columbus Ave, Sandusky, OH 44870 USA. EM brian.e.washburn@aphis.usda.gov FU US Department of Defense Legacy Resource Management Program FX We thank the US Department of Defense Legacy Resource Management Program for funding this project. We appreciate the encouragement, professional advice, and data access provided by the FAA. B. Blackwell, T. Seamans, and an anonymous reviewer provided helpful comments on earlier drafts of the manuscript. This manuscript reflects the views of the National Wildlife Research Center and does not necessarily reflect the views of the DoD Legacy Resource Management Program or the FAA. NR 11 TC 3 Z9 4 U1 3 U2 10 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 1361-9209 J9 TRANSPORT RES D-TR E JI Transport. Res. Part D-Transport. Environ. PD OCT PY 2013 VL 24 BP 83 EP 88 DI 10.1016/j.trd.2013.06.004 PG 6 WC Environmental Studies; Transportation; Transportation Science & Technology SC Environmental Sciences & Ecology; Transportation GA 234TT UT WOS:000325667900011 ER PT J AU Lowery, W Lowery, A Barnett, J Acecevdo, ML Lee, P Alvarez-Secord, A Havrilesky, L AF Lowery, W. Lowery, A. Barnett, J. Acecevdo, M. Lopez Lee, P. Alvarez-Secord, A. Havrilesky, L. TI Cost effectiveness of early palliative care intervention in recurrent platinum resistant ovarian cancer SO GYNECOLOGIC ONCOLOGY LA English DT Meeting Abstract C1 [Lowery, W.; Lowery, A.; Acecevdo, M. Lopez; Lee, P.; Alvarez-Secord, A.; Havrilesky, L.] Duke Univ, Med Ctr, Durham, NC USA. [Barnett, J.] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0090-8258 EI 1095-6859 J9 GYNECOL ONCOL JI Gynecol. Oncol. PD OCT PY 2013 VL 131 IS 1 BP 283 EP 284 DI 10.1016/j.ygyno.2013.04.043 PG 2 WC Oncology; Obstetrics & Gynecology SC Oncology; Obstetrics & Gynecology GA 237BF UT WOS:000325842500142 ER PT J AU Maseng, T Landry, R Young, K AF Maseng, Torleiv Landry, Randall Young, Kenneth TI MILITARY COMMUNICATIONS SO IEEE COMMUNICATIONS MAGAZINE LA English DT Editorial Material C1 [Maseng, Torleiv] Norwegian Def Res Estab, Trondheim, Norway. [Maseng, Torleiv] SINTEF, N-7034 Trondheim, Norway. [Maseng, Torleiv] NC3A NATO Res Ctr, The Hague, Netherlands. [Maseng, Torleiv] Lund Univ, S-22100 Lund, Sweden. [Maseng, Torleiv] Norwegian Def Res Estab FFI, Kjeller, Norway. [Maseng, Torleiv] Univ Oslo, N-0316 Oslo, Norway. [Landry, Randall] US Dept Def, Washington, DC 20305 USA. [Young, Kenneth] Appl Commun Sci, Govt Project Dev Appl Res Org, Basking Ridge, NJ USA. [Young, Kenneth] US Army, Res Lab, Commun & Networks Collaborat Technol Alliance, Washington, DC USA. [Young, Kenneth] US Army, CERDEC, Proact Integrated Link Select Network Robustness, Washington, DC USA. RP Maseng, T (reprint author), Norwegian Def Res Estab, Trondheim, Norway. EM torleiv.maseng@ffi.no; rlandry@mitre.org; kyoung@appcomsci.com NR 0 TC 0 Z9 0 U1 0 U2 4 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0163-6804 EI 1558-1896 J9 IEEE COMMUN MAG JI IEEE Commun. Mag. PD OCT PY 2013 VL 51 IS 10 BP 32 EP 33 PG 2 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA 235CD UT WOS:000325691700002 ER PT J AU Tortonesi, M Morelli, A Stefanelli, C Kohler, R Suri, N Watson, S AF Tortonesi, Mauro Morelli, Alessandro Stefanelli, Cesare Kohler, Ralph Suri, Niranjan Watson, Scott TI Enabling the Deployment of COTS Applications in Tactical Edge Networks SO IEEE COMMUNICATIONS MAGAZINE LA English DT Article ID ENVIRONMENTS OBSERVATIONS; EXPERIENCES AB The increasing adoption of COTS hardware and software technologies in tactical scenarios raises the issue of supporting the deployment of legacy and COTS applications in extremely dynamic and challenging environments such as tactical edge networks (TENs). COTS applications adopt standards devised for wired Internet environments or corporate networks, such as service oriented architectures, and TCP and UDP, thus exhibiting severe reliability and performance problems on TENs. To support the reuse and deployment of COTS applications in TENs, there is the need to develop solutions that mediate the application requirements with the communication semantics of TENs. This article presents an overview of the challenges in deploying COTS applications in TENs and presents NetProxy, a state-of-the-art solution explicitly designed to address them. C1 [Tortonesi, Mauro; Morelli, Alessandro; Stefanelli, Cesare] Univ Ferrara, Dept Engn, I-44100 Ferrara, Italy. [Kohler, Ralph] US Air Force, Res Lab, Washington, DC USA. [Suri, Niranjan] Florida Inst Human & Machine Cognit, Tampa, FL USA. [Suri, Niranjan] US Army, Res Lab, Adelphi, MD USA. [Watson, Scott] Space & Naval Warfare Syst Ctr, Charleston, SC USA. RP Tortonesi, M (reprint author), Univ Ferrara, Dept Engn, I-44100 Ferrara, Italy. EM mauro.tortonesi@unife.it; alessandro.morelli@unife.it; cesare.stefanelli@unife.it; Ralph.Kohler@rl.af.mil; nsuri@ihmc.us; scott.c.watson@navy.mil OI Tortonesi, Mauro/0000-0002-7417-4455; Morelli, Alessandro/0000-0003-3309-3461 NR 14 TC 5 Z9 5 U1 0 U2 4 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0163-6804 EI 1558-1896 J9 IEEE COMMUN MAG JI IEEE Commun. Mag. PD OCT PY 2013 VL 51 IS 10 BP 66 EP 73 PG 8 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA 235CD UT WOS:000325691700007 ER PT J AU Allik, B Ilg, M Zurakowski, R AF Allik, Bethany Ilg, Mark Zurakowski, Ryan TI Ballistic Roll Estimation using EKF Frequency Tracking and Adaptive Noise Cancellation SO IEEE TRANSACTIONS ON AEROSPACE AND ELECTRONIC SYSTEMS LA English DT Article ID EXTENDED KALMAN FILTER; DESIGN AB We present an attitude estimation method for self-guided ballistic munitions from onboard magnetometers. An adaptive feedback filter is used to remove actuator-induced magnetic disturbances whose spectrum overlaps the signal of interest. A state-augmented extended Kalman filter (EKF) is used to estimate roll rate and sensor bias from the filtered data. Experimental results demonstrate that this method is able to accurately estimate the roll without phase delay inherent in other methods. C1 [Allik, Bethany; Zurakowski, Ryan] Univ Delaware, Dept Elect & Comp Engn, Newark, DE 19711 USA. [Ilg, Mark] US Army Res Lab, Adelphi, MD 20783 USA. RP Allik, B (reprint author), Univ Delaware, Dept Elect & Comp Engn, 331 DuPont Hall, Newark, DE 19711 USA. EM ballik@udel.edu OI Zurakowski, Ryan/0000-0003-3726-3114 FU U.S. Army Research Office [W911NF-10-1-0386] FX This work is supported by the U.S. Army Research Office under Grant W911NF-10-1-0386. NR 14 TC 8 Z9 10 U1 0 U2 13 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0018-9251 EI 1557-9603 J9 IEEE T AERO ELEC SYS JI IEEE Trans. Aerosp. Electron. Syst. PD OCT PY 2013 VL 49 IS 4 BP 2546 EP 2553 PG 8 WC Engineering, Aerospace; Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA 235ZQ UT WOS:000325763100031 ER PT J AU Shelley, J Abraham, D McAlpin, T AF Shelley, John Abraham, David McAlpin, Tate TI Removing Systemic Bias in Bed-Load Transport Measurements in Large Sand-Bed Rivers SO JOURNAL OF HYDRAULIC ENGINEERING LA English DT Article DE Bed loads; Rivers and streams; Measurement; Missouri; Sediment transport; Bedload; Sand-bed rivers; Bathymetry; Dunes; Rivers and streams; Measurement AB Bed-load sediment transport is important yet difficult to measure in large, sand-bed rivers. Prior work established in theory and validated in a flume study a method known as integrated section surface difference over time version 2 (ISSDOTv2), which computes bed-load transport using sequential three dimensional (3D) bathymetric profiles. The same work identified a source of systemic error leading to an underprediction of computed transport rates. This paper demonstrates how the systemic error can be removed from ISSDOTv2 calculations to produce a more accurate dune transport value. This is demonstrated by analytic and geometric examples, and with field data from the Missouri River at Kansas City. The results of these analyses indicate that field data do exhibit the systematic error and that it is possible to extrapolate a corrected dune bed-load transport rate from field data obtained at different measurement intervals. Additionally, error bounds on this corrected value can be set. Independent validation of the resulting transport rate was not attempted due to the unreliability of physical measurements for bed-load transport in large sand-bed rivers. C1 [Shelley, John] US Army Corps Engineers, River Engn & Restorat Sect, Kansas City, MO 64106 USA. [Abraham, David] US Army Corps Engineers, Engn Res & Dev Ctr, Coastal & Hydraul Lab, Vicksburg, MS 39180 USA. [McAlpin, Tate] Engn Res & Dev Ctr, Coastal & Hydraul Lab, Vicksburg, MS 39180 USA. RP Shelley, J (reprint author), US Army Corps Engineers, River Engn & Restorat Sect, 601 E 12th St, Kansas City, MO 64106 USA. EM john.shelley@usace.army.mil; david.d.abraham@usace.army.mil; tate.O.McAlpin@usace.army.mil FU U.S. Army Corps of Engineers Kansas City District FX Funding for this work was provided by the U.S. Army Corps of Engineers Kansas City District. Field work and internal reviews were conducted by personnel at the U.S. Army Corps of Engineers Engineering Research and Development Center. The authors would like to thank two anonymous reviewers for their helpful comments. NR 8 TC 1 Z9 1 U1 1 U2 8 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 0733-9429 EI 1943-7900 J9 J HYDRAUL ENG JI J. Hydraul. Eng.-ASCE PD OCT 1 PY 2013 VL 139 IS 10 BP 1107 EP 1111 DI 10.1061/(ASCE)HY.1943-7900.0000760 PG 5 WC Engineering, Civil; Engineering, Mechanical; Water Resources SC Engineering; Water Resources GA 218XG UT WOS:000324465400010 ER PT J AU Kowalski, PC Dowben, JS Keltner, NL AF Kowalski, Peter C. Dowben, Jonathan S. Keltner, Norman L. TI Ammonium: the Deadly Toxin You Don't Want to Miss When Using Mood Stabilizers SO PERSPECTIVES IN PSYCHIATRIC CARE LA English DT Article DE Glutamate transamination; encephalopathy; hyperammonemia; valproic acid ID HYPERAMMONEMIC ENCEPHALOPATHY; VALPROIC ACID C1 [Dowben, Jonathan S.] Brooke Army Med Ctr, Pediat & Behav Hlth Serv, Ft Sam Houston, TX 78234 USA. [Keltner, Norman L.] Univ Alabama Birmingham, Sch Nursing, Birmingham, AL 35294 USA. RP Keltner, NL (reprint author), Univ Alabama Birmingham, Sch Nursing, Birmingham, AL 35294 USA. EM nkeltner@uab.edu NR 9 TC 1 Z9 1 U1 0 U2 1 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0031-5990 EI 1744-6163 J9 PERSPECT PSYCHIATR C JI Perspect. Psychiatr. Care PD OCT PY 2013 VL 49 IS 4 BP 221 EP 225 DI 10.1111/ppc.12040 PG 5 WC Nursing; Psychiatry SC Nursing; Psychiatry GA 230NM UT WOS:000325347900002 PM 25187442 ER PT J AU Bland, CM Sweeney, LB Tritsch, AM Bookstaver, DA Choi, YU AF Bland, Christopher M. Sweeney, Lori B. Tritsch, Adam M. Bookstaver, David A. Choi, Yong U. TI Change in levothyroxine dose requirements after bariatric surgery. SO PHARMACOTHERAPY LA English DT Meeting Abstract CT Annual Meeting of the American-College-of-Clinical-Pharmacy (ACCP) CY OCT 13-16, 2013 CL Albuquerque, NM SP Amer Coll Clin Pharm C1 [Bland, Christopher M.; Sweeney, Lori B.; Tritsch, Adam M.; Bookstaver, David A.; Choi, Yong U.] Eisenhower Army Med Ctr, Ft Gordon, GA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0277-0008 EI 1875-9114 J9 PHARMACOTHERAPY JI Pharmacotherapy PD OCT PY 2013 VL 33 IS 10 MA 69 BP E202 EP E203 PG 2 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA 230RM UT WOS:000325360100097 ER PT J AU Martin, WA Lee, LS Schwab, P AF Martin, W. Andy Lee, Linda S. Schwab, Paul TI Antimony migration trends from a small arms firing range compared to lead, copper, and zinc SO SCIENCE OF THE TOTAL ENVIRONMENT LA English DT Article DE Antimony; Small arms firing range; Migration; Bullet corrosion ID SHOOTING RANGES; SPECIATION; OXIDATION; BEHAVIOR; SB(III); SB(V); SOILS AB Small arms firing ranges (SAFRs) contain a mixed amount of bullets and bullet fragments accumulated throughout their designed lifetime. Lead-antimony (Pb-Sb) alloy copper (Cu) jacketed bullets are a common modern ammunition used at SAFRs. The impact of bullets with berm material (i.e., soil) generates a heterogeneous distribution of bullets and bullet fragments in the surrounding soil. As bullets and bullet fragments corrode in the berm soil, the migration potential for antimony compared to other metals is quite high. The goal of this study was to evaluate the spatial Sb migration potential from an SAFR as compared to lead, copper, and zinc (Zn) migration from the same SAFR. Berm soil samples were collected along with surface and ground water samples for a preliminary investigation of the Sb migration from an active SAFR. In addition, different aqueous sample preservation techniques were used and evaluated. Soil sample analysis results show the presence of the metals (i.e., Pb, Sb, Cu, and Zn) in the range floor soil samples, indicating the migration of these metals from the berm to the range floor. The groundwater samples indicate that Sb was migrating from the SAFR more readily than the other metals based on the concentration of Sb in the monitoring well farthest from the SAFR berm. Published by Elsevier B.V. C1 [Martin, W. Andy] US Army Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA. [Martin, W. Andy; Lee, Linda S.; Schwab, Paul] Purdue Univ, Dept Agron, W Lafayette, IN 47907 USA. [Schwab, Paul] Texas A&M Univ, Dept Soil & Crop Sci, College Stn, TX 77843 USA. RP Martin, WA (reprint author), US Army Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA. EM Andy.Martin@usace.army.mil NR 31 TC 5 Z9 6 U1 1 U2 34 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0048-9697 EI 1879-1026 J9 SCI TOTAL ENVIRON JI Sci. Total Environ. PD OCT 1 PY 2013 VL 463 BP 222 EP 228 DI 10.1016/j.scitotenv.2013.05.086 PG 7 WC Environmental Sciences SC Environmental Sciences & Ecology GA 236WW UT WOS:000325831200025 PM 23810861 ER PT J AU Hakre, S Manak, MM Murray, CK Davis, KW Bose, M Harding, AJ Maas, PR Jagodzinski, LL Kim, JH Michael, NL Rentas, FJ Peel, SA Scott, PT Tovanabutra, S AF Hakre, Shilpa Manak, Mark M. Murray, Clinton K. Davis, Kenneth W. Bose, Meera Harding, Aaron J. Maas, Peter R. Jagodzinski, Linda L. Kim, Jerome H. Michael, Nelson L. Rentas, Francisco J. Peel, Sheila A. Scott, Paul T. Tovanabutra, Sodsai TI Transfusion-transmitted human T-lymphotropic virus Type I infection in a United States military emergency whole blood transfusion recipient in Afghanistan, 2010 SO TRANSFUSION LA English DT Article ID CELL LEUKEMIA-LYMPHOMA; GEOGRAPHICAL SUBTYPES; SINGLE-DONOR; US MILITARY; HTLV-I; TRANSMISSION; POPULATIONS; MYELOPATHY; COMPONENTS; GUINEA AB BackgroundThe United States introduced human T-lymphotropic virus Type I (HTLV-I) screening of blood donors in 1988. The US military uses freshly collected blood products for life-threatening injuries when available stored blood components in theater have been exhausted or when these components are unsuccessful for resuscitation. These donors are screened after donation by the Department of Defense (DoD) retrospective testing program. All recipients of blood collected in combat are tested according to policy soon after and at 3, 6, and 12 months after transfusion. Case ReportA 31-year-old US Army soldier tested positive for HTLV-I 44 days after receipt of emergency blood transfusions for severe improvised explosive device blast injuries. One donor's unit tested HTLV-I positive on the DoD-mandated retrospective testing. Both the donor and the recipient tested reactive with enzyme immunoassay and supplemental confirmation by HTLV-I Western blot. The donor and recipient reported no major risk factors for HTLV-I. Phylogenetic analysis of HTLV-I sequences indicated Cosmopolitan subtype, Subgroup B infections. Comparison of long terminal repeat and env sequences revealed molecular genetic linkage of the viruses from the donor and recipient. ConclusionThis case is the first report of transfusion transmission of HTLV-I in the US military during combat operations. The emergency fresh whole blood policy enabled both the donor and the recipient to be notified of their HTLV-I infection. While difficult in combat, predonation screening of potential emergency blood donors with Food and Drug Administration-mandated infectious disease testing as stated by the DoD Health Affairs policy should be the goal of every facility engaged with emergency blood collection in theater. C1 Armed Serv Blood Program Off, Falls Church, VA USA. San Antonio Mil Med Ctr, San Antonio, TX USA. Henry M Jackson Fdn Adv Mil Med, US Mil HIV Res Program, Bethesda, MD USA. Walter Reed Army Inst Res, US Mil HIV Res Program, Rockville, MD USA. RP Hakre, S (reprint author), US Mil HIV Res Program, 6720-A Rockledge Dr,Suite 400, Bethesda, MD 20817 USA. EM shakre@hivresearch.org OI Manak, Mark /0000-0002-9217-9129 FU Armed Services Blood Program; Military Infectious Diseases Research Program FX This work was supported by funds from the Armed Services Blood Program and Military Infectious Diseases Research Program. NR 26 TC 7 Z9 7 U1 0 U2 3 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0041-1132 EI 1537-2995 J9 TRANSFUSION JI Transfusion PD OCT PY 2013 VL 53 IS 10 BP 2176 EP 2182 DI 10.1111/trf.12101 PG 7 WC Hematology SC Hematology GA 230WP UT WOS:000325374300015 PM 23362944 ER PT J AU Poret, JC Shaw, AP Csernica, CM Oyler, KD Vanatta, JA Chen, G AF Poret, Jay C. Shaw, Anthony P. Csernica, Christopher M. Oyler, Karl D. Vanatta, Jessica A. Chen, Gary TI Versatile Boron Carbide-Based Energetic Time Delay Compositions SO ACS SUSTAINABLE CHEMISTRY & ENGINEERING LA English DT Article DE Pyrotechnic delay; Boron carbide; Periodate; Hand-held signal; Sustainable chemistry ID HAND-HELD SIGNAL; PYROTECHNICS AB Pyrotechnic time delay compositions composed of boron carbide, sodium periodate, and polytetrafluoroethylene have been developed for use in the U.S. Army hand-held signal. The new compositions were developed to replace the currently used composition that contains potassium perchlorate and barium chromate, chemicals that are facing increasing regulatory scrutiny. Static tests in aluminum hand-held signal delay housings demonstrated a wide range of available inverse burning rates (1.3-20.8 s/cm), which includes the 7-8.5 s/cm range required for hand-held signals. The roles of loading pressure, mixture stoichiometry, and component particle size are described herein. C1 [Poret, Jay C.; Shaw, Anthony P.; Csernica, Christopher M.; Oyler, Karl D.; Vanatta, Jessica A.; Chen, Gary] USA, Armament Res Dev & Engn Ctr, RDECOM, ARDEC, Picatinny Arsenal, NJ 07806 USA. RP Shaw, AP (reprint author), USA, Armament Res Dev & Engn Ctr, RDECOM, ARDEC, Picatinny Arsenal, NJ 07806 USA. EM anthony.p.shaw.civ@mail.mil FU U.S. Army through the RDECOM Environmental Quality Technology Program FX The U.S. Army is thanked for funding this work through the RDECOM Environmental Quality Technology Program. NR 40 TC 8 Z9 8 U1 2 U2 15 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 2168-0485 J9 ACS SUSTAIN CHEM ENG JI ACS Sustain. Chem. Eng. PD OCT PY 2013 VL 1 IS 10 BP 1333 EP 1338 DI 10.1021/sc400187h PG 6 WC Chemistry, Multidisciplinary; GREEN & SUSTAINABLE SCIENCE & TECHNOLOGY; Engineering, Chemical SC Chemistry; Science & Technology - Other Topics; Engineering GA 232RP UT WOS:000325512000016 ER PT J AU Gerhardt, RT AF Gerhardt, R. T. TI Tactical Study of Care Originating in the Out-of-Hospital Environment (TACSCOPE): Out-of-Hospital Application of Predictor Guidelines for Massive Transfusion and Survival SO ANNALS OF EMERGENCY MEDICINE LA English DT Meeting Abstract CT Research Forum of the American-College-of-Emergency-Physicians (ACEP) CY OCT 14-15, 2013 CL Seattle, WA SP Amer Coll Emergency Phys C1 [Gerhardt, R. T.] US Army Inst Surg Res, TACSCOPE Investigators, Brooke Army Med Ctr, Ft Sam Houston, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0196-0644 J9 ANN EMERG MED JI Ann. Emerg. Med. PD OCT PY 2013 VL 62 IS 4 SU S BP S115 EP S115 PG 1 WC Emergency Medicine SC Emergency Medicine GA 232PO UT WOS:000325506500320 ER PT J AU Wampler, DA Convertino, V Weeks, WS Hernandez, M Manifold, C AF Wampler, D. A. Convertino, V Weeks, W. S. Hernandez, M. Manifold, C. TI Addition of Impedance Threshold Device Therapy Improves Blood Pressure in the Out-of-Hospital Spontaneously Breathing Hypotensive Patient SO ANNALS OF EMERGENCY MEDICINE LA English DT Meeting Abstract CT Research Forum of the American-College-of-Emergency-Physicians (ACEP) CY OCT 14-15, 2013 CL Seattle, WA SP Amer Coll Emergency Phys C1 Manifold C UT Hlth Sci Ctr San Antonio, San Antonio, TX USA. US Army Inst Surg Res, San Antonio, TX USA. Southwest Texas Reg Advisory Council Trauma, San Antonio, TX USA. San Antonio Fire Dept, San Antonio, TX USA. NR 0 TC 1 Z9 1 U1 0 U2 0 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0196-0644 J9 ANN EMERG MED JI Ann. Emerg. Med. PD OCT PY 2013 VL 62 IS 4 SU S BP S145 EP S146 PG 2 WC Emergency Medicine SC Emergency Medicine GA 232PO UT WOS:000325506500402 ER PT J AU Welc, SS Clanton, TL Dineen, SM Leon, LR AF Welc, Steven S. Clanton, Thomas L. Dineen, Shauna M. Leon, Lisa R. TI Heat stroke activates a stress-induced cytokine response in skeletal muscle SO JOURNAL OF APPLIED PHYSIOLOGY LA English DT Article DE IL-6; IL-10; heat stress; myokines; toll-like receptors ID TUMOR-NECROSIS-FACTOR; NF-KAPPA-B; TNF-ALPHA; INFLAMMATORY RESPONSE; MACROPHAGE PHENOTYPE; ENDOCRINE ORGAN; GENE-EXPRESSION; MOUSE SKELETAL; IMMUNE CELLS; IN-VIVO AB Heat stroke (HS) induces a rapid elevation in a number of circulating cytokines. This is often attributed to the stimulatory effects of endotoxin, released from damaged intestine, on immune cells. However, parenchymal cells also produce cytokines, and skeletal muscle, comprising a large proportion of body mass, is thought to participate. We tested the hypothesis that skeletal muscle exhibits a cytokine response to HS that parallels the systemic response in conscious mice heated to a core temperature of 42.4 degrees C (T-cMax). Diaphragm and hindlimb muscles showed a rapid rise in interleukin-6 (IL-6) and interleuin-10 (IL-10) mRNA and transient inhibition of tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 beta (IL-1 beta) throughout early recovery, a pattern that parallels changes in circulating cytokines. IL-6 protein was transiently elevated in both muscles at similar to 32 min after reaching T-cMax. Other responses observed included an upregulation of toll-like receptor-4 (TLR-4) and heat shock protein-72 (HSP-72) mRNA but no change in TLR-2 or HSP25 mRNA. Furthermore, c-jun and c-fos mRNA increased. Together, c-jun/c-fos form the activator protein-1 (AP-1) transcription factor, critical for stress-induced regulation of IL-6. Interestingly, a second "late-phase" (24 h) cytokine response, with increases in IL-6, IL-10, IL-1 beta, and TNF-alpha protein, were observed in hindlimb but not diaphragm muscle. These results demonstrate that skeletal muscle responds to HS with a distinct "stress-induced immune response," characterized by an early upregulation of IL-6, IL-10, and TLR-4 and suppression of IL-1 beta and TNF-alpha mRNA, a pattern discrete from classic innate immune cytokine responses. C1 [Welc, Steven S.; Dineen, Shauna M.; Leon, Lisa R.] US Army Res Inst Environm Med, Thermal & Mt Med Div, Natick, MA USA. [Welc, Steven S.; Clanton, Thomas L.] Univ Florida, Dept Appl Physiol & Kinesiol, Coll Hlth & Human Performance, Gainesville, FL 32611 USA. RP Clanton, TL (reprint author), Univ Florida, Dept Appl Physiol & Kinesiol, Rm 100 FLG,POB 118205, Gainesville, FL 32611 USA. EM tclanton@hhp.ufl.edu FU Oak Ridge Institute of Science and Education; US Army Medical Research and Material Command; American Heart Association [11GRNT7990119] FX The work was supported by the Oak Ridge Institute of Science and Education (SSW), US Army Medical Research and Material Command (LRL), and the American Heart Association #11GRNT7990119 (TLC). NR 74 TC 18 Z9 19 U1 1 U2 10 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 8750-7587 EI 1522-1601 J9 J APPL PHYSIOL JI J. Appl. Physiol. PD OCT PY 2013 VL 115 IS 8 BP 1126 EP 1137 DI 10.1152/japplphysiol.00636.2013 PG 12 WC Physiology; Sport Sciences SC Physiology; Sport Sciences GA 237KU UT WOS:000325869400003 PM 23928112 ER PT J AU Convertino, VA Grudic, G Mulligan, J Moulton, S AF Convertino, Victor A. Grudic, Greg Mulligan, Jane Moulton, Steve TI Estimation of individual-specific progression to impending cardiovascular instability using arterial waveforms SO JOURNAL OF APPLIED PHYSIOLOGY LA English DT Article DE hemorrhage; blood pressure; stroke volume; modeling; shock ID HEART PERIOD VARIABILITY; BODY NEGATIVE-PRESSURE; ALPHA(1) ADRENERGIC-STIMULATION; PREHOSPITAL TRAUMA PATIENTS; CENTRAL HYPOVOLEMIA; LIFESAVING INTERVENTIONS; CARDIAC-OUTPUT; PULSE PRESSURE; STROKE VOLUME; TOLERANCE AB Trauma patients with "compensated" internal hemorrhage may not be identified with standard medical monitors until signs of shock appear, at which point it may be difficult or too late to pursue life-saving interventions. We tested the hypothesis that a novel machine-learning model called the compensatory reserve index (CRI) could differentiate tolerance to acute volume loss of individuals well in advance of changes in stroke volume (SV) or standard vital signs. Two hundred one healthy humans underwent progressive lower body negative pressure (LBNP) until the onset of hemodynamic instability (decompensation). Continuously measured photoplethysmogram signals were used to estimate SV and develop a model for estimating CRI. Validation of the CRI was tested on 101 subjects who were classified into two groups: low tolerance (LT; n = 33) and high tolerance (HT; n = 68) to LBNP (mean LBNP time: LT = 16.23 min vs. HT = 25.86 min). On an arbitrary scale of 1 to 0, the LT group CRI reached 0.6 at an average time of 5.27 +/- 1.18 (95% confidence interval) min followed by 0.3 at 11.39 +/- 1.14 min. In comparison, the HT group reached CRI of 0.6 at 7.62 +/- 0.94 min followed by 0.3 at 15.35 +/- 1.03 min. Changes in heart rate, blood pressure, and SV did not differentiate HT from LT groups. Machine modeling of the photoplethysmogram response to reduced central blood volume can accurately trend individual-specific progression to hemodynamic decompensation. These findings foretell early identification of blood loss, anticipating hemodynamic instability, and timely application of life-saving interventions. C1 [Convertino, Victor A.] US Army Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Grudic, Greg; Mulligan, Jane; Moulton, Steve] Flashback Technol Inc, Boulder, CO USA. [Moulton, Steve] Univ Colorado, Denver, CO 80202 USA. RP Convertino, VA (reprint author), US Army Inst Surg Res, Ft Sam Houston, TX 78234 USA. EM victor.a.convertino.civ@mail.mil FU United States Army Medical Research and Materiel Command Combat Casualty Research Program FX Funding support was provided by the United States Army Medical Research and Materiel Command Combat Casualty Research Program. NR 37 TC 21 Z9 21 U1 0 U2 10 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 8750-7587 EI 1522-1601 J9 J APPL PHYSIOL JI J. Appl. Physiol. PD OCT PY 2013 VL 115 IS 8 BP 1196 EP 1202 DI 10.1152/japplphysiol.00668.2013 PG 7 WC Physiology; Sport Sciences SC Physiology; Sport Sciences GA 237KU UT WOS:000325869400011 PM 23928113 ER PT J AU Peters, JF Walizer, LE AF Peters, John F. Walizer, Laura E. TI Patterned Nonaffine Motion in Granular Media SO JOURNAL OF ENGINEERING MECHANICS LA English DT Article DE Discrete elements; Localization; Granular media; Boundaries; Affine motion; Multiscale; Nonlocal continuum; Hierarchical; Discrete-element method; Localization ID ASSEMBLIES; DEFORMATION; EVOLUTION; FAILURE; MODEL AB Vortex-like flow patterns are often observed in experiments on granular media for which uniform strain is expected based on the loading boundary conditions. These deformations become apparent when the motion associated with uniform strain is subtracted from the total particle motion. Besides presenting an interesting phenomenon that begs explanation, these vortex patterns suggest multiscale structure for nonaffine motion as suggested by modern continuum theories. Further, the authors note that the rotational velocity field added to a uniform strain field produces a planar slip field. Thus, these structures are associated with the slip-band fields that eventually form, which are generally associated with bifurcations in the solution path of the governing partial differential equations. The authors present a procedure to extract these motion fields from discrete-element simulations along with conjugate forces associated with these motions. A key finding from the simulations is that the motions that eventually lead to shear band formation develop throughout the loading history rather than arising as a distinct bifurcation. Further, the pattern of rotational fields, and hence the shear banding pattern, are controlled by the boundary conditions. A question, only partly resolved here, is the origin of forces driving the rotational fields. C1 [Peters, John F.; Walizer, Laura E.] US Army Engineer Res & Dev Ctr, Geotech & Struct Lab, Vicksburg, MS 39180 USA. RP Walizer, LE (reprint author), US Army Engineer Res & Dev Ctr, Geotech & Struct Lab, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM laura.walizer@usace.army.mil NR 23 TC 12 Z9 12 U1 0 U2 6 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 0733-9399 EI 1943-7889 J9 J ENG MECH JI J. Eng. Mech. PD OCT 1 PY 2013 VL 139 IS 10 BP 1479 EP 1490 DI 10.1061/(ASCE)EM.1943-7889.0000556 PG 12 WC Engineering, Mechanical SC Engineering GA 219DC UT WOS:000324484300016 ER PT J AU Batiuk, RA Linker, LC Cerco, CF AF Batiuk, Richard A. Linker, Lewis C. Cerco, Carl F. TI FEATURED COLLECTION INTRODUCTION: CHESAPEAKE BAY TOTAL MAXIMUM DAILY LOAD DEVELOPMENT AND APPLICATION SO JOURNAL OF THE AMERICAN WATER RESOURCES ASSOCIATION LA English DT Article ID AQUATIC VEGETATION; MODEL C1 [Batiuk, Richard A.; Linker, Lewis C.] US EPA, Chesapeake Bay Program Off, Annapolis, MD 21403 USA. [Cerco, Carl F.] US Army Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Batiuk, RA (reprint author), US EPA, Chesapeake Bay Program Off, 410 Severn Ave,Suite 109, Annapolis, MD 21403 USA. EM batiuk.richard@epa.gov NR 16 TC 0 Z9 1 U1 1 U2 9 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1093-474X EI 1752-1688 J9 J AM WATER RESOUR AS JI J. Am. Water Resour. Assoc. PD OCT PY 2013 VL 49 IS 5 BP 981 EP 985 DI 10.1111/jawr.12114 PG 5 WC Engineering, Environmental; Geosciences, Multidisciplinary; Water Resources SC Engineering; Geology; Water Resources GA 227YW UT WOS:000325152600001 ER PT J AU Linker, LC Batiuk, RA Shenk, GW Cerco, CF AF Linker, Lewis C. Batiuk, Richard A. Shenk, Gary W. Cerco, Carl F. TI DEVELOPMENT OF THE CHESAPEAKE BAY WATERSHED TOTAL MAXIMUM DAILY LOAD ALLOCATION SO JOURNAL OF THE AMERICAN WATER RESOURCES ASSOCIATION LA English DT Article DE Chesapeake Bay; Chesapeake Bay Program; TMDLs; integrated environmental models; water quality standards; dissolved oxygen; chlorophyll; water clarity; watershed management; nitrogen; phosphorus; sediment ID EUTROPHICATION; MODEL AB Nutrient load allocations and subsequent reductions in total nitrogen and phosphorus have been applied in the Chesapeake watershed since 1992 to reduce hypoxia and to restore living resources. In 2010, sediment allocations were established to augment nutrient allocations supporting the submerged aquatic vegetation resource. From the initial introduction of nutrient allocations in 1992 to the present, the allocations have become more completely applied to all areas and loads in the watershed and have also become more rigorously assessed and tracked. The latest 2010 application of nutrient and sediment allocations were made as part of the Chesapeake Bay total maximum daily load and covered all six states of the Chesapeake watershed. A quantitative allocation process was developed that applied principles of equity and efficiency in the watershed, while achieving all tidal water quality standards through an assessment of equitable levels of effort in reducing nutrients and sediments. The level of effort was determined through application of two key watershed scenarios: one where no action was taken in nutrient control and one where maximum nutrient control efforts were applied. Once the level of effort was determined for different jurisdictions, the overall load reduction was set watershed-wide to achieve dissolved oxygen water quality standards. Further adjustments were made to the allocation to achieve the James River chlorophyll-a standard. C1 [Linker, Lewis C.; Batiuk, Richard A.; Shenk, Gary W.] US EPA, Chesapeake Bay Program Off, Annapolis, MD 21403 USA. [Cerco, Carl F.] US Army Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Linker, LC (reprint author), US EPA, Chesapeake Bay Program Off, 410 Severn Ave,Suite 109, Annapolis, MD 21403 USA. EM linker.lewis@epa.gov NR 49 TC 13 Z9 15 U1 2 U2 30 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1093-474X EI 1752-1688 J9 J AM WATER RESOUR AS JI J. Am. Water Resour. Assoc. PD OCT PY 2013 VL 49 IS 5 BP 986 EP 1006 DI 10.1111/jawr.12105 PG 21 WC Engineering, Environmental; Geosciences, Multidisciplinary; Water Resources SC Engineering; Geology; Water Resources GA 227YW UT WOS:000325152600002 ER PT J AU Kim, SC AF Kim, Sung-Chan TI EVALUATION OF A THREE-DIMENSIONAL HYDRODYNAMIC MODEL APPLIED TO CHESAPEAKE BAY THROUGH LONG-TERM SIMULATION OF TRANSPORT PROCESSES SO JOURNAL OF THE AMERICAN WATER RESOURCES ASSOCIATION LA English DT Article DE estuaries; hydrodynamics; computational methods; simulation ID SALINITY AB A numerical model, the Curvilinear Hydrodynamics in 3-Dimensions, Waterway Experiment Station version (CH3D-WES), was applied to represent transport processes of the Chesapeake Bay. Grid resolution and spatial coverage, tied with realistic bathymetry, ensured dynamic responses along the channel and near the shoreline. The model was run with the forcing ranges from high frequency astronomical tides to lower frequency meteorological forcing, given by surface wind and heat flux, as well as hydrological forcing given by fresh water inflows both from upstream and distributed sources along the shoreline. To validate the model, a long-term simulation over seven-year time period between 1994 and 2000 was performed. The model results were compared with existing observation data including water level time series, which spans over a wide spectrum of time scales, and long-term variations in salinity structures over varying parts of the Bay. The validated model is set to provide an appropriate transport mechanism to the water quality model through linkage, warranting that the model takes into account the complexity in time and spatial scales associated with the dynamic processes in the Chesapeake. C1 US Army Corps Engineers, Engineer Res & Dev Ctr, Coastal Hydraul Lab, Vicksburg, MS 39180 USA. RP Kim, SC (reprint author), US Army Corps Engineers, Engineer Res & Dev Ctr, Coastal Hydraul Lab, Vicksburg, MS 39180 USA. EM sung-chan.kim@usace.army.mil FU US Army Engineer District, Baltimore; USEPA CBP Office; Dredging Operations Environmental Research Program of the US Army Corps of Engineers by the US Army Engineer Research and Development Center FX This study was funded by the US Army Engineer District, Baltimore, and by the USEPA CBP Office. Additional funding was from the Dredging Operations Environmental Research Program of the US Army Corps of Engineers by the US Army Engineer Research and Development Center. The model implementation was possible through constructive reviews and discussion with colleagues including Dr. Larry Sanford of University of Maryland, Dr. Chris Sherwood of United Geological Survey, and Dr. Courtney Harris of Virginia Institute of Marine Science. This article may be referred as EPA-903-R-13-006 and/or CBP/TRS-312-13-5. NR 15 TC 3 Z9 3 U1 1 U2 15 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1093-474X EI 1752-1688 J9 J AM WATER RESOUR AS JI J. Am. Water Resour. Assoc. PD OCT PY 2013 VL 49 IS 5 BP 1078 EP 1090 DI 10.1111/jawr.12113 PG 13 WC Engineering, Environmental; Geosciences, Multidisciplinary; Water Resources SC Engineering; Geology; Water Resources GA 227YW UT WOS:000325152600007 ER PT J AU Cerco, CF Noel, MR Wang, P AF Cerco, Carl F. Noel, Mark R. Wang, Ping TI THE SHALLOW-WATER COMPONENT OF THE CHESAPEAKE BAY ENVIRONMENTAL MODEL PACKAGE SO JOURNAL OF THE AMERICAN WATER RESOURCES ASSOCIATION LA English DT Article DE turbidity; macrophytes; sediment transport; eutrophication; simulation; Chesapeake Bay ID SUBMERSED AQUATIC VEGETATION; DIFFUSE ATTENUATION COEFFICIENT; EUTROPHICATION; QUALITY AB The shallow-water component of the Chesapeake Bay Environmental Model Package emphasizes the regions of the system inside the 2-m depth contour. The model of these regions is unified with the system-wide model but places emphasis on locally significant components and processes, notably submerged aquatic vegetation (SAV), sediment resuspension, and their interaction with light attenuation (Ke). The SAV model is found to be most suited for computing the equilibrium distribution of perennial species. Addition of plant structure and propagation are recommended to improve representation of observed trends in SAV area. Two approaches are taken to examining shallow-water Ke. The first compares observed and computed differences between deep- and shallow-water Ke. No consistent difference in observations is noted. In the preponderance of regions examined, computed shallow-water Ke exceeds computed deep-water Ke. The second approach directly compares Ke measured in shallow water with modeled results. Model values are primarily lower than observed, in contrast to results in deep water where model values exceed observed. The shortfall in computed Ke mirrors a similar shortfall in computed suspended solids. Improved model representation of Ke requires process-based investigations into suspended solids dynamics as well as increased model resolution in shallow-water regions. C1 [Cerco, Carl F.; Noel, Mark R.] US Army Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. [Wang, Ping] Virginia Inst Marine Sci, Chesapeake Bay Off, Annapolis, MD USA. RP Cerco, CF (reprint author), US Army Engineer Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM carl.f.cerco@usace.army.mil FU US Army Engineer District, Baltimore; US Environmental Protection Agency Chesapeake Bay Program Office FX This study was funded by the US Army Engineer District, Baltimore, and by the US Environmental Protection Agency Chesapeake Bay Program Office. The optical model was contributed by Dr. Charles Gallegos of the Smithsonian Environmental Research Center. US Environmental Protection Agency publication EPA-903-R-13-009, Chesapeake Bay Program publication CBP/TRS-315-13-8. NR 27 TC 2 Z9 2 U1 0 U2 13 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1093-474X EI 1752-1688 J9 J AM WATER RESOUR AS JI J. Am. Water Resour. Assoc. PD OCT PY 2013 VL 49 IS 5 BP 1091 EP 1102 DI 10.1111/jawr.12106 PG 12 WC Engineering, Environmental; Geosciences, Multidisciplinary; Water Resources SC Engineering; Geology; Water Resources GA 227YW UT WOS:000325152600008 ER PT J AU Cerco, CF Noel, MR AF Cerco, Carl F. Noel, Mark R. TI TWENTY-ONE-YEAR SIMULATION OF CHESAPEAKE BAY WATER QUALITY USING THE CE-QUAL-ICM EUTROPHICATION MODEL SO JOURNAL OF THE AMERICAN WATER RESOURCES ASSOCIATION LA English DT Article DE transport and fate; eutrophication; simulation; Chesapeake Bay ID AQUATIC VEGETATION; RIVER FLOW; NUTRIENT; PHYTOPLANKTON; VARIABILITY; HYPOXIA AB The CE-QUAL-ICM (Corps of Engineers Integrated Compartment Water Quality Model) eutrophication model was applied in a 21-year simulation of Chesapeake Bay water quality, 1985-2005. The eutrophication model is part of a larger model package and is forced, in part, by models of atmospheric deposition, watershed flows and loads, and hydrodynamics. Results from the model are compared with observations in multiple formats including time series plots, cumulative distribution plots, and statistical summaries. The model indicates only one long-term trend in computed water quality: light attenuation deteriorates circa 1993 through the end of the simulation. The most significant result is the influence of physical processes, notably stratification and associated effects (e.g., anoxic volume), on computed water quality. Within the application period, physical effects are more important determinants of year-to-year variability in computed water quality than external loads. C1 [Cerco, Carl F.; Noel, Mark R.] US Army Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Cerco, CF (reprint author), US Army Engineer Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM carl.f.cerco@usace.army.mil FU US Army Engineer District, Baltimore; US Environmental Protection Agency Chesapeake Bay Program Office FX This study was funded by the US Army Engineer District, Baltimore, and by the US Environmental Protection Agency Chesapeake Bay Program Office. Rebecca Murphy provided the anoxic volumes for individual sampling cruises. US Environmental Protection Agency publication EPA-903-R-13-011, Chesapeake Bay program publication CBP/TRS-317-13-10. NR 33 TC 16 Z9 17 U1 2 U2 25 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1093-474X EI 1752-1688 J9 J AM WATER RESOUR AS JI J. Am. Water Resour. Assoc. PD OCT PY 2013 VL 49 IS 5 BP 1119 EP 1133 DI 10.1111/jawr.12107 PG 15 WC Engineering, Environmental; Geosciences, Multidisciplinary; Water Resources SC Engineering; Geology; Water Resources GA 227YW UT WOS:000325152600010 ER PT J AU Theiling, CH Burant, JT AF Theiling, C. H. Burant, J. T. TI FLOOD INUNDATION MAPPING FOR INTEGRATED FLOODPLAIN MANAGEMENT: UPPER MISSISSIPPI RIVER SYSTEM SO RIVER RESEARCH AND APPLICATIONS LA English DT Article DE Upper Mississippi River; flood inundation; hydrology; geomorphology; ecosystem services; integrated floodplain management ID ARCHAEOLOGICAL RECORD; MISSOURI RIVER; PATTERNS; REGIME; STAGE; CONNECTIVITY; ECOSYSTEMS; STREAMFLOW; INTEGRITY; HABITATS AB Natural hydrogeomorphic characteristics and hydrologic alterations are important ecological drivers, and hydrology is also a common ecological, flood control and navigation system indicator. Hydrologic characteristics change dramatically from one end of the Upper Mississippi River System to the other, and hydraulic characteristics also differ spatially across the river channels and floodplain in response to dams, levees and diversions. Low flow surface water spatial change in response to navigation and flood control has been well known for many years, but little information was available on the spatial distribution of frequent floods. The flow frequency data presented here were developed to better estimate contemporary floods after historic flooding in 1993. Flood stage estimates are enhanced in GIS to help quantify and map potential floodplain inundation for more than 1000 river miles on the Upper Mississippi and Illinois Rivers. Potential flood inundation is mapped for the 50% to 0.2% annual exceedance probability flood stage (i.e. 2- to 500-year expected recurrence interval flood) and also for alternative floodplain management scenarios within the existing flood protection infrastructure. Our analysis documents: (i) impoundment effects, (ii) a hydrologic gradient within the navigation pools that creates repeating patterns of riverine, backwater and impounded aquatic habitat conditions, (iii) potential floodplain inundation patterns for over 2 million acres and (iv) several integrated floodplain management scenarios. Extreme flood events are more common in recent decades, and they are expected to continue to occur at greater frequency in response to climate change. Floodplain managers can use the results presented here to help optimize land management and flood damage reduction on the Upper Mississippi River System. Published 2012. This article is a U.S. Government work and is in the public domain in the USA. C1 [Theiling, C. H.; Burant, J. T.] US Army Corps Engineers, Rock Isl, IL 61204 USA. RP Theiling, CH (reprint author), US Army Corps Engineers, POB 2004,Clock Tower Bldg, Rock Isl, IL 61204 USA. EM Charles.h.theiling@usace.army.mil FU US Army Corps of Engineers Long Term Training grant; Navigation and Ecosystem Sustainability Program FX Charles Theiling was partially supported by a US Army Corps of Engineers Long Term Training grant and the Navigation and Ecosystem Sustainability Program. John Burant and several other engineers completed hydrologic and hydraulic modelling for the US Army Corps of Engineers, Upper Mississippi River System, Flow Frequency Study. NR 83 TC 8 Z9 8 U1 0 U2 58 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1535-1459 EI 1535-1467 J9 RIVER RES APPL JI River Res. Appl. PD OCT PY 2013 VL 29 IS 8 BP 961 EP 978 DI 10.1002/rra.2583 PG 18 WC Environmental Sciences; Water Resources SC Environmental Sciences & Ecology; Water Resources GA 232DJ UT WOS:000325469700002 ER PT J AU Scott, ML Auble, GT Dixon, MD Johnson, WC Rabbe, LA AF Scott, M. L. Auble, G. T. Dixon, M. D. Johnson, W. Carter Rabbe, L. A. TI LONG-TERM COTTONWOOD FOREST DYNAMICS ALONG THE UPPER MISSOURI RIVER, USA SO RIVER RESEARCH AND APPLICATIONS LA English DT Article DE channel narrowing; cottonwood; dams; forest dynamics; GIS; Missouri River; state and transition models; vegetation cover types ID RIPARIAN FORESTS; MILK RIVER; MONTANA; RECRUITMENT; VEGETATION; ESTABLISHMENT; REGENERATION; FLOODPLAIN; SURVIVAL; ALBERTA AB The upper Missouri River bottomland in north-central Montana, USA, retains much of the physical character it had when traversed by Lewis and Clark around 1805. We used geospatial data to quantify long-term changes in the distribution of bottomland vegetation, land use patterns and channel planform for a 257-rkm segment of the Missouri River above Fort Peck Reservoir. This segment is less ecologically altered than downstream segments, but two dams completed in the mid-1950s have decreased the frequency and magnitude of floods. The area of forest is sparse because of geomorphic setting but, contrary to public perception, has remained relatively constant during the past century. However, the stability of forest area obscures its spatial and temporal dynamics. We used state and transition models to quantify fates and sources of forest during two periods: 1890s-1950s and 1950s-2006. Total forest area was 6% greater in 2006 than it was in the 1890s, largely due to reduced forest loss to erosional processes and gains related to progressive channel narrowing. Channel narrowing resulted in part from human-caused peak flow attenuation. A modified transition matrix, used to examine future steady-state conditions, projected little change in forest area; however, these projections are likely an overestimate. The extent to which 2006 forest area represents a transient adjustment to a new flow regime versus a dynamic, quasi-steady state will be determined by the long-term interplay among hydrologic factors, channel processes, water management and land use practices. Published 2012. This article is a U.S. Government work and is in the public domain in the USA. C1 [Scott, M. L.; Auble, G. T.] US Geol Survey, Ft Sci Ctr, Ft Collins, CO 80526 USA. [Dixon, M. D.] Univ S Dakota, Dept Biol Sci, Vermillion, SD 57069 USA. [Johnson, W. Carter] S Dakota State Univ, Dept Nat Resources, Brookings, SD 57007 USA. [Rabbe, L. A.] US Army Corps Engineers, Div Engn, Kansas City, MO 64106 USA. RP Scott, ML (reprint author), US Geol Survey, Ft Sci Ctr, 2150 Ctr Ave,Bldg C, Ft Collins, CO 80526 USA. EM scottm@usgs.gov RI Dixon, Mark/F-2641-2011 OI Dixon, Mark/0000-0002-0345-5655 FU US Army Corps of Engineers; Bureau of Land Management; US Geological Survey FX This work is part of a larger effort to develop basin-wide understanding of cottonwood forest structure, composition and dynamics, funded by the US Army Corps of Engineers. More intensive work in the Fort Benton to Fort Peck segment was supported by the Bureau of Land Management and the US Geological Survey. The authors thank Tammy Fancher for invaluable GIS assistance and support. Mike Merigliano provided the repeat oblique photograph of Iron City Island as well as many insights and productive field days along the Missouri River. Elizabeth Peltz, Christopher Peltz, Mike Dodrill and Lindsey Washkoviak assisted with mapping and ground-truthing. Thanks to Pat Anderson and Leanne Hanson for helpful reviews and to Billy Maxwell for information and insights regarding the steamship era. Finally, thanks to Stew Rood for some time on the river. NR 35 TC 5 Z9 6 U1 2 U2 24 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1535-1459 EI 1535-1467 J9 RIVER RES APPL JI River Res. Appl. PD OCT PY 2013 VL 29 IS 8 BP 1016 EP 1029 DI 10.1002/rra.2588 PG 14 WC Environmental Sciences; Water Resources SC Environmental Sciences & Ecology; Water Resources GA 232DJ UT WOS:000325469700006 ER PT J AU Kesavan, J Schepers, DR Bottiger, JR King, MD McFarland, AR AF Kesavan, Jana Schepers, Deborah R. Bottiger, Jerold R. King, Maria D. McFarland, Andrew R. TI Aerosolization of Bacterial Spores with Pressurized Metered Dose Inhalers SO AEROSOL SCIENCE AND TECHNOLOGY LA English DT Article ID BACILLUS-ANTHRACIS AB Bioaerosol detection and identification systems need to be periodically checked for assurance that they are responsive to aerosol challenges. Herein, pressurized metered dose inhalers (pMDIs) containing ethanol suspensions of two simulants for B. anthracis spores are considered for providing suitable aerosols. Doses and shot weights from pMDIs with canisters having volumes equal to that of 200 metering-valve actuations were constant for 165 actuations, but drop beyond that range. There were statistically significant dose variations between replicate pMDIs and between two types of actuators used on the pMDIs. The storage half-lives of pMDIs filled with Bacillus atrophaeus (BG) and Bacillus thuringiensis subsp. israelensis (Bti) spore formulations are predicted to be 32 and 136 months, respectively, if the canisters are stored under refrigeration (4 degrees C). The prediction is based on use of a logarithmic regression model relating CFU per actuation to storage time, with data taken at times of 1-12 months. Demonstration of the utility of the concept was provided by producing responses from a polymerase chain reaction (PCR) identifier with pMDI-generated BG and Bti aerosols that were collected with a 100 L/min wetted wall bioaerosol sampling cyclone. Copyright 2013 American Association for Aerosol Research C1 [Kesavan, Jana; Bottiger, Jerold R.] US Army Edgewood Chem Biol Ctr, Aerosol Sci Lab, Aberdeen Proving Ground, MD 21005 USA. [Schepers, Deborah R.; Bottiger, Jerold R.] EXCET Inc, Springfield, VA USA. [King, Maria D.] Texas A&M Univ, Dept Mech Engn, Aerosol Technol Lab, College Stn, TX 77843 USA. [McFarland, Andrew R.] AR McFarland PhD PE Inc, Houston, TX USA. RP Kesavan, J (reprint author), US Army Edgewood Chem Biol Ctr, Aerosol Sci Lab, Aberdeen Proving Ground, MD 21005 USA. EM jana.kesavan@us.army.mil NR 32 TC 1 Z9 1 U1 0 U2 8 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA SN 0278-6826 J9 AEROSOL SCI TECH JI Aerosol Sci. Technol. PD OCT 1 PY 2013 VL 47 IS 10 BP 1108 EP 1117 DI 10.1080/02786826.2013.824552 PG 10 WC Engineering, Chemical; Engineering, Mechanical; Environmental Sciences; Meteorology & Atmospheric Sciences SC Engineering; Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences GA 222JF UT WOS:000324726300007 ER PT J AU Heipertz, RA Sanders-Buell, E Kijak, G Howell, S Lazzaro, M Jagodzinski, LL Eggleston, J Peel, S Malia, J Armstrong, A Michael, NL Kim, JH O'Connell, RJ Scott, PT Brett-Major, DM Tovanabutra, S AF Heipertz, Richard A., Jr. Sanders-Buell, Eric Kijak, Gustavo Howell, Shana Lazzaro, Michelle Jagodzinski, Linda L. Eggleston, John Peel, Sheila Malia, Jennifer Armstrong, Adam Michael, Nelson L. Kim, Jerome H. O'Connell, Robert J. Scott, Paul T. Brett-Major, David M. Tovanabutra, Sodsai TI Molecular Epidemiology of Early and Acute HIV Type 1 Infections in the United States Navy and Marine Corps, 2005-2010 SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Article ID MILITARY PERSONNEL; SEXUAL TRANSMISSION; RISK-FACTORS; US ARMY; SEQUENCES; SEROCONVERSION; PHYLOGENETICS; SURVEILLANCE; CONSISTENT; DYNAMICS AB The U.S. military represents a unique population within the human immunodeficiency virus 1 (HIV-1) pandemic. The last comprehensive study of HIV-1 in members of the U.S. Navy and Marine Corps (Sea Services) was completed in 2000, before large-scale combat operations were taking place. Here, we present molecular characterization of HIV-1 from 40 Sea Services personnel who were identified during their seroconversion window and initially classified as HIV-1 negative during screening. Protease/reverse transcriptase (pro/rt) and envelope (env) sequences were obtained from each member of the cohort. Phylogenetic analyses were carried out on these regions to determine relatedness within the cohort and calculate the most recent common ancestor for the related sequences. We identified 39 individuals infected with subtype B and one infected with CRF01_AE. Comparison of the pairwise genetic distance of Sea Service sequences and reference sequences in the env and pro/rt regions showed that five samples were part of molecular clusters, a group of two and a group of three, confirmed by single genome amplification. Real-time molecular monitoring of new HIV-1 acquisitions in the Sea Services may have a role in facilitating public health interventions at sites where related HIV-1 infections are identified. C1 [Heipertz, Richard A., Jr.; Sanders-Buell, Eric; Kijak, Gustavo; Howell, Shana; Lazzaro, Michelle; Jagodzinski, Linda L.; Eggleston, John; Peel, Sheila; Malia, Jennifer; Michael, Nelson L.; Kim, Jerome H.; O'Connell, Robert J.; Scott, Paul T.; Tovanabutra, Sodsai] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD 20910 USA. [Sanders-Buell, Eric; Kijak, Gustavo; Howell, Shana; Lazzaro, Michelle; Eggleston, John; Tovanabutra, Sodsai] Henry M Jackson Fdn Adv Mil Med Inc, Bethesda, MD USA. [Malia, Jennifer] US PHS, Rockville, MD USA. [Armstrong, Adam] Navy Marine Corps Publ Hlth Ctr, Navy Bloodborne Infect Management Ctr, Bethesda, MD USA. [Brett-Major, David M.] Naval Med Res Ctr, Silver Spring, MD USA. [Brett-Major, David M.] Uniformed Serv Univ Hlth Sci, Dept Prevent Med & Biometr, Bethesda, MD 20814 USA. RP Tovanabutra, S (reprint author), Walter Reed Army Inst Res, US Mil HIV Res Program, Lab Mol Virol & Pathogenesis, Viral Genet Sect, 503 Robert Grant Ave,Room 2N25, Silver Spring, MD 20910 USA. EM stovanabutra@hivresearch.org FU U.S. Navy Bureau of Medicine and Surgery; Military Infectious Diseases Research Program [MIDRP-H014010OTPPOC]; Henry M. Jackson Foundation for the Advancement of Military Medicine [W81XWH-07-2-0067]; Department of Defense FX This project was funded in part by the U.S. Navy Bureau of Medicine and Surgery and the Military Infectious Diseases Research Program, project MIDRP-H014010OTPPOC. These studies were supported by a cooperative agreement (W81XWH-07-2-0067) between the Henry M. Jackson Foundation for the Advancement of Military Medicine and the Department of Defense. NR 37 TC 2 Z9 2 U1 1 U2 5 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0889-2229 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD OCT 1 PY 2013 VL 29 IS 10 BP 1310 EP 1320 DI 10.1089/aid.2013.0087 PG 11 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA 224UQ UT WOS:000324915800005 PM 23972100 ER PT J AU Kijak, GH Pham, P Sanders-Buell, E Harbolick, EA Eller, LA Robb, ML Michael, NL Kim, JH Tovanabutra, S AF Kijak, Gustavo H. Phuc Pham Sanders-Buell, Eric Harbolick, Elizabeth A. Eller, Leigh Anne Robb, Merlin L. Michael, Nelson L. Kim, Jerome H. Tovanabutra, Sodsai TI Nautilus: A Bioinformatics Package for the Analysis of HIV Type 1 Targeted Deep Sequencing Data SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Article ID ERROR SOURCES; DNA AB The advent of next generation sequencing technologies is providing new insight into HIV-1 diversity and evolution, which has created the need for bioinformatics tools that could be applied to the characterization of viral quasispecies. Here we present Nautilus, a bioinformatics package for the analysis of HIV-1 targeted deep sequencing data. The DeepHaplo module determines the nucleotide base frequency and read depth at each position and computes the haplotype frequencies based on the linkage among polymorphisms in the same next generation sequence read. The Motifs module computes the frequency of the variants in the setting of their sequence context and mapping orientation, which allows for the validation of polymorphisms and haplotypes when strand bias is suspected. Both modules are accessed through a user-friendly GUI, which runs on Mac OS X (version 10.7.4 or later), and are based on Python, JAVA, and R scripts. Nautilus is available from www.hivresearch.org/research.php?ServiceID=5&SubServiceID=6. C1 [Kijak, Gustavo H.; Phuc Pham; Sanders-Buell, Eric; Harbolick, Elizabeth A.; Eller, Leigh Anne; Robb, Merlin L.; Tovanabutra, Sodsai] Henry M Jackson Fdn Adv Mil Med, US Mil HIV Res Program, Bethesda, MD USA. [Michael, Nelson L.; Kim, Jerome H.] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD 20910 USA. RP Kijak, GH (reprint author), Walter Reed Army Inst Res, Henry M Jackson Fdn, US Mil HIV Res Program, 503 Robert Grant Ave,Room 2N27, Silver Spring, MD 20910 USA. EM gkijak@hivresearch.org FU U.S. Army Medical Research and Materiel Command [Y1-AI-2642-12]; National Institute of Allergy and Infectious Diseases [Y1-AI-2642-12]; Henry M. Jackson Foundation for the Advancement of Military Medicine [W81XWH-07-2-0067]; U.S. Department of Defense [W81XWH-07-2-0067] FX This work was supported in part by an Interagency Agreement (Y1-AI-2642-12) between the U.S. Army Medical Research and Materiel Command and the National Institute of Allergy and Infectious Diseases. This work was also supported by a cooperative agreement (W81XWH-07-2-0067) between the Henry M. Jackson Foundation for the Advancement of Military Medicine and the U.S. Department of Defense. NR 12 TC 2 Z9 2 U1 1 U2 5 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0889-2229 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD OCT 1 PY 2013 VL 29 IS 10 BP 1361 EP 1364 DI 10.1089/aid.2013.0175 PG 4 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA 224UQ UT WOS:000324915800011 PM 23809062 ER PT J AU Corona, BT Garg, K Ward, CL McDaniel, JS Walters, TJ Rathbone, CR AF Corona, B. T. Garg, K. Ward, C. L. McDaniel, J. S. Walters, T. J. Rathbone, C. R. TI Autologous minced muscle grafts: a tissue engineering therapy for the volumetric loss of skeletal muscle SO AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY LA English DT Article DE minced muscle graft; volumetric muscle loss; skeletal muscle injury and damage; tissue engineering; tissue regeneration ID SATELLITE CELLS; EXTRACELLULAR-MATRIX; CONNECTIVE-TISSUE; GROWTH-FACTOR; LOSS INJURY; IN-VIVO; REGENERATION; RAT; FIBERS; REPAIR AB Volumetric muscle loss (VML) results in a large void deficient in the requisite materials for regeneration for which there is no definitive clinical standard of care. Autologous minced muscle grafts (MG), which contain the essential components for muscle regeneration, may embody an ideal tissue engineering therapy for VML. The purpose of this study was to determine if orthotopic transplantation of MG acutely after VML in the tibialis anterior muscle of male Lewis rats promotes functional tissue regeneration. Herein we report that over the first 16 wk postinjury, MG transplantation 1) promotes remarkable regeneration of innervated muscle fibers within the defect area (i.e., de novo muscle fiber regeneration); 2) reduced evidence of chronic injury in the remaining muscle mass compared with nonrepaired muscles following VML (i.e., transplantation attenuated chronically upregulated transforming growth factor-beta(1) gene expression and the presence of centrally located nuclei in 30% of fibers observed in nonrepaired muscles); and 3) significantly improves net torque production (i.e., similar to 55% of the functional deficit in nonrepaired muscles was restored). Additionally, voluntary wheel running was shown to reduce the heightened accumulation of extracellular matrix deposition observed within the regenerated tissue of MG-repaired sedentary rats 8 wk postinjury (collagen 1% area: sedentary vs. runner, similar to 41 vs. 30%), which may have been the result of an augmented inflammatory response [i.e., M-1 (CCR7) and M-2 (CD163) macrophage expression was significantly greater in runner than sedentary MG-repaired muscles 2 wk postinjury]. These findings support further exploration of autologous minced MGs for the treatment of VML. C1 [Corona, B. T.; Garg, K.; Ward, C. L.; McDaniel, J. S.; Walters, T. J.; Rathbone, C. R.] US Army, Inst Surg Res, Extrem Trauma & Regenerat Med Res Program, Ft Sam Houston, TX 78234 USA. RP Corona, BT (reprint author), US Army, Inst Surg Res, 3698 Chambers Pass, Ft Sam Houston, TX 78234 USA. EM benjamin.t.corona.vol@mail.mil FU US Army Medical Research and Materiel Command [F-021-2013-USAISR] FX These studies were funded by the US Army Medical Research and Materiel Command Grant F-021-2013-USAISR. NR 71 TC 31 Z9 31 U1 2 U2 10 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 0363-6143 J9 AM J PHYSIOL-CELL PH JI Am. J. Physiol.-Cell Physiol. PD OCT PY 2013 VL 305 IS 7 BP C761 EP C775 DI 10.1152/ajpcell.00189.2013 PG 15 WC Cell Biology; Physiology SC Cell Biology; Physiology GA 230NL UT WOS:000325347700010 PM 23885064 ER PT J AU Kuhn, JH Bekal, S Cai, YY Clawson, AN Domier, LL Herrel, M Jahrling, PB Kondo, H Lambert, KN Mihindukulasuriya, KA Nowotny, N Radoshitzky, SR Schneider, U Staeheli, P Suzuki, N Tesh, RB Wang, D Wang, LF Dietzgen, RG AF Kuhn, Jens H. Bekal, Sadia Cai, Yingyun Clawson, Anna N. Domier, Leslie L. Herrel, Marieke Jahrling, Peter B. Kondo, Hideki Lambert, Kris N. Mihindukulasuriya, Kathie A. Nowotny, Norbert Radoshitzky, Sheli R. Schneider, Urs Staeheli, Peter Suzuki, Nobuhiro Tesh, Robert B. Wang, David Wang, Lin-Fa Dietzgen, Ralf G. TI Nyamiviridae: Proposal for a new family in the order Mononegavirales SO ARCHIVES OF VIROLOGY LA English DT Article ID ARGAS-PERSICARGAS-ARBOREUS; METAGENOMIC ANALYSIS; QUARANFIL CHENUDA; NYAMANINI VIRUSES; MATRIX PROTEIN; VIRAL WORLD; RNA VIRUSES; ARBOVIRUSES; TICKS; EGYPT AB Nyamanini virus (NYMV) and Midway virus (MIDWV) are unclassified tick-borne agents that infect land birds and seabirds, respectively. The recent molecular characterization of both viruses confirmed their already known close serological relationship and revealed them to be nonsegmented, single- and negative-stranded RNA viruses that are clearly related to, but quite distinct from, members of the order Mononegavirales (bornaviruses, filoviruses, paramyxoviruses, and rhabdoviruses). A third agent, soybean cyst nematode virus 1 (SbCNV-1, previously named soybean cyst nematode nyavirus), was recently found to be an additional member of this new virus group. Here, we review the current knowledge about all three viruses and propose classifying them as members of a new mononegaviral family, Nyamiviridae. C1 [Kuhn, Jens H.; Cai, Yingyun; Clawson, Anna N.; Jahrling, Peter B.] NIAID, Integrated Res Facil Ft Detrick IRF Frederick, Div Clin Res DCR, NIH, Frederick, MD 21702 USA. [Bekal, Sadia] Univ Illinois, Dept Agr & Biol Engn, Chicago, IL 60680 USA. [Domier, Leslie L.; Lambert, Kris N.] Univ Illinois, Dept Crop Sci, Chicago, IL 60680 USA. [Herrel, Marieke; Schneider, Urs; Staeheli, Peter] Univ Freiburg, Dept Virol, D-79106 Freiburg, Germany. [Kondo, Hideki; Suzuki, Nobuhiro] Okayama Univ, Inst Plant Sci & Resources, Kurashiki, Okayama, Japan. [Mihindukulasuriya, Kathie A.] Washington Univ, Sch Med, Genome Inst, St Louis, MO USA. [Nowotny, Norbert] Univ Vet Med, Vienna, Austria. [Nowotny, Norbert] Sultan Qaboos Univ, Coll Med & Hlth Sci, Muscat, Oman. [Radoshitzky, Sheli R.] US Army Med Res Inst Infect Dis, Frederick, MD USA. [Tesh, Robert B.] Univ Texas Med Branch, Dept Pathol, Galveston, TX 77555 USA. [Tesh, Robert B.] Univ Texas Med Branch, Ctr Biodef & Emerging Infect Dis, Galveston, TX 77555 USA. [Wang, David] Washington Univ, Sch Med, Dept Mol Microbiol, St Louis, MO 63110 USA. [Wang, David] Washington Univ, Sch Med, Dept Pathol & Immunol, St Louis, MO USA. [Wang, Lin-Fa] CSIRO, Australian Anim Hlth Lab, Geelong, Vic, Australia. [Wang, Lin-Fa] Duke Natl Univ Singapore NUS, Grad Sch Med, Program Emerging Infect Dis, Singapore, Singapore. [Dietzgen, Ralf G.] Univ Queensland, Queensland Alliance Agr & Food Innovat, St Lucia, Qld, Australia. RP Kuhn, JH (reprint author), NIAID, Integrated Res Facil Ft Detrick IRF Frederick, Div Clin Res DCR, NIH, B-8200 Res Plaza, Frederick, MD 21702 USA. EM kuhnjens@mail.nih.gov RI Suzuki, Nobuhiro/B-2517-2011; Kuhn, Jens H./B-7615-2011; OI Kuhn, Jens H./0000-0002-7800-6045; Mihindukulasuriya, Kathie/0000-0001-9372-3758 FU Intramural NIH HHS [Z99 AI999999] NR 69 TC 7 Z9 8 U1 1 U2 16 PU SPRINGER WIEN PI WIEN PA SACHSENPLATZ 4-6, PO BOX 89, A-1201 WIEN, AUSTRIA SN 0304-8608 EI 1432-8798 J9 ARCH VIROL JI Arch. Virol. PD OCT PY 2013 VL 158 IS 10 BP 2209 EP 2226 DI 10.1007/s00705-013-1674-y PG 18 WC Virology SC Virology GA 226BA UT WOS:000325008000028 PM 23636404 ER PT J AU Borowicz, DT Bank, LC AF Borowicz, David T. Bank, Lawrence C. TI Effect of web reinforcement on the behavior of pultruded fiber-reinforced polymer beams subjected to concentrated loads SO CONSTRUCTION AND BUILDING MATERIALS LA English DT Article DE FRP beams; Concentrated loads; Web stiffeners; Digital image correlation AB This paper describes an experimental program designed and executed to investigate the failure mode and ultimate capacity of web-reinforced pultruded FRP beams subjected to concentrated loads in the plane of the web. Six 203.2 mm x 101.6 mm x 12.7 mm beams and five 203.2 mm x 203.2 mm x 9.5 mm beams manufactured with vinylester resin were strengthened with one of three systems and subjected to concentrated loads applied directly to the top flange. The three systems were (a) full-depth web bearing stiffeners, (b) "doubler" plates attached to the web, or (c) stiffening elements applied to the upper (loaded) web-flange junction of the specimen. Experimental results showed that the junction stiffeners (58.7%), bearing stiffeners (52.8%), and "doubler" plates (31.7%) all increased the ultimate capacity of the beams when compared to unstrengthened control beams. Beams prepared with bearing stiffeners and "doubler" plates failed in the same manner as the control beams (shear "wedge" failure at loaded web-flange junction), while failure in the beams with reinforced loaded web-flange junctions occurred in the bottom flange near the simple supports. Digital image correlation software was used to capture out of plane displacement of the web and confirms the modes of failure. Published by Elsevier Ltd. C1 [Borowicz, David T.] US Mil Acad, Dept Civil & Mech Engn, West Point, NY 10996 USA. [Bank, Lawrence C.] CUNY City Coll, Dept Civil Engn, New York, NY 10031 USA. RP Borowicz, DT (reprint author), US Mil Acad, Dept Civil & Mech Engn, 752 Thayer Rd,331 Mahan Hall, West Point, NY 10996 USA. EM david.borowicz@usma.edu; lbank2@ccny.cuny.edu NR 9 TC 2 Z9 2 U1 1 U2 2 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0950-0618 J9 CONSTR BUILD MATER JI Constr. Build. Mater. PD OCT PY 2013 VL 47 BP 347 EP 357 DI 10.1016/j.conbuildmat.2013.05.081 PG 11 WC Construction & Building Technology; Engineering, Civil; Materials Science, Multidisciplinary SC Construction & Building Technology; Engineering; Materials Science GA 228ZW UT WOS:000325232600041 ER PT J AU Casem, DT Zellner, MB AF Casem, D. T. Zellner, M. B. TI Kolsky Bar Wave Separation Using a Photon Doppler Velocimeter SO EXPERIMENTAL MECHANICS LA English DT Article DE Kolsky bar; Split Hopkinson Pressure Bar; Wave separation; Photon Doppler velocimetry; High strain rate ID HOPKINSON PRESSURE BAR; ELASTIC-WAVES; DISPERSION; PROPAGATION AB A method to permit wave separation with a Kolsky bar is described. A photon Doppler velocimeter (PDV) is used to measure particle velocity at the location of each strain-gage. These measurements are used with the measured strain to separate wave-trains that in general exist in each bar (for example, an incident and reflected pulse) even when they are superimposed at the gage location. This can extend the duration of the experiment and permit more freedom in the types of loadings that can be applied to a specimen. It was found that the PDV measurement of particle velocity often contains a significant component due to bending waves. A method to account for bending is described but requires multiple PDV measurements at each gage position. C1 [Casem, D. T.] US Army Res Lab, RDRL WMP C, Aberdeen Proving Ground, MD 21005 USA. [Zellner, M. B.] US Army Res Lab, RDRL WMP D, Aberdeen Proving Ground, MD 21005 USA. RP Casem, DT (reprint author), US Army Res Lab, RDRL WMP C, Aberdeen Proving Ground, MD 21005 USA. EM daniel.t.casem.civ@mail.mil NR 25 TC 4 Z9 4 U1 0 U2 11 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0014-4851 EI 1741-2765 J9 EXP MECH JI Exp. Mech. PD OCT PY 2013 VL 53 IS 8 BP 1467 EP 1473 DI 10.1007/s11340-013-9735-4 PG 7 WC Materials Science, Multidisciplinary; Mechanics; Materials Science, Characterization & Testing SC Materials Science; Mechanics GA 226BQ UT WOS:000325009600016 ER PT J AU Walker, RW Brown, RS Deters, KA Eppard, MB Cooke, SJ AF Walker, Ricardo W. Brown, Richard S. Deters, Katherine A. Eppard, M. Brad Cooke, Steven J. TI Does UV disinfection compromise sutures? An evaluation of tissue response and suture retention in salmon surgically implanted with transmitters SO FISHERIES RESEARCH LA English DT Article DE Ultraviolet radiation; Sterilization; Disinfection; Sutures; Juvenile Chinook ID JUVENILE CHINOOK SALMON; SURVIVAL; GROWTH; TROUT; FISH AB Ultraviolet radiation (UVR) can be used as a tool to disinfect surgery tools used for implanting transmitters into fish. However, the use of UVR could possibly degrade monofilament suture material used to close surgical incisions. This research examined the effect of UVR on monofilament sutures to determine if they were compromised and negatively influenced tag and suture retention, incision openness, or tissue reaction. Eighty juvenile Chinook salmon Oncorhynchus tshawytscha were surgically implanted with an acoustic transmitter and a passive integrated transponder. The incision was closed with a single stitch of either a suture exposed to 20 doses of UV radiation (5 min duration per dose) or a new, sterile suture. Fish were then held for 28 days and examined under a microscope at day 7, 14, 21 and 28 for incision openness, ulceration, redness, and the presence of water mold. There was no significant difference between treatments for incision openness, redness, ulceration or the presence of water mold on any examination day. On day 28 post-surgery, there were no lost sutures; however, 2 fish lost their transmitters (one from each treatment). The results of this study do not show any differences in negative influences such as tissue response, suture retention or tag retention between a new sterile suture and a suture disinfected with UVR. (C) 2013 Elsevier B.V. All rights reserved. C1 [Walker, Ricardo W.; Brown, Richard S.; Deters, Katherine A.] Pacific NW Natl Lab, Ecol Grp, Richland, WA 99352 USA. [Eppard, M. Brad] US Army Corps Engineers, Portland, OR 97208 USA. [Cooke, Steven J.] Carleton Univ, Dept Biol, Fish Ecol & Conservat Physiol Lab, Ottawa, ON K1S 5B6, Canada. [Cooke, Steven J.] Carleton Univ, Inst Environm Sci, Ottawa, ON K1S 5B6, Canada. RP Walker, RW (reprint author), Pacific NW Natl Lab, Ecol Grp, Richland, WA 99352 USA. EM Ricardo.walker@pnnl.gov RI Cooke, Steven/F-4193-2010 OI Cooke, Steven/0000-0002-5407-0659 FU U.S. Army Corps of Engineers (USACE); U.S. DOE [DE-AC05-76RL01830] FX Funding was provided by the U.S. Army Corps of Engineers (USACE). We thank Alison H. Colotelo, Jill M. Janak, Andrea P. Le Barge, Tim J. Linley, Gayle L. Dirkes, David R. Geist, and Brett D. Pflugrath of PNNL. PNNL animal facilities are AALAC certified; fish were handled in accordance with federal guidelines for the care and use of laboratory animals, and study protocols were approved by the PNNL IACUC. PNNL is operated by Battelle for the U.S. DOE (contract DE-AC05-76RL01830). NR 21 TC 2 Z9 2 U1 0 U2 4 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0165-7836 J9 FISH RES JI Fish Res. PD OCT PY 2013 VL 147 BP 32 EP 35 DI 10.1016/j.fishres.2013.04.010 PG 4 WC Fisheries SC Fisheries GA 228MW UT WOS:000325191900004 ER PT J AU Jackson, SJT Murphy, LL Venema, RC Singletary, KW Young, AJ AF Jackson, Steven J. T. Murphy, Laura L. Venema, Richard C. Singletary, Keith W. Young, Andrew J. TI Curcumin binds tubulin, induces mitotic catastrophe, and impedes normal endothelial cell proliferation SO FOOD AND CHEMICAL TOXICOLOGY LA English DT Article DE Cell cycle; Curcumin; Endothelial; Tubulin ID CANCER CELLS; OXIDATIVE STRESS; CYCLE ARREST; MICROTUBULE POLYMERIZATION; HEME OXYGENASE; APOPTOSIS; BILIRUBIN; ANTIOXIDANT; AGENT; DIFERULOYLMETHANE AB Curcumin, a component of turmeric spice that imparts flavor and color to curry, is thought to possess anti-inflammatory and antioxidant properties in biological tissues. However, while such efficacies have been described in the context of carcinogenesis, the impact of curcumin on normal cell cycle regulation is poorly understood. Here, we provide evidence of curcumin toxicity in proliferating bovine aortic endothelial cells, at concentrations relevant to the diet and below those previously reported in cancer models. Upon confirming curcumin's ability to upregulate hemeoxygenase-1 in a dose-dependent fashion, we found the minimally efficacious curcumin concentration to also inhibit endothelial cell DNA synthesis. Moreover, curcumin concentrations below the minimum 2 mu M threshold required to induce hemeoxygenase-1 bound tubulin protein in vitro and triggered hallmark evidence of mitotic catastrophe in vivo. Concentrations as low as 0.1 mu M curcumin led to disproportionate DNA segregation, karyorrhexis, and micronucleation in proliferating endothelial cells. While suggesting a mechanism by which physiological curcumin concentrations inhibit cell cycle progression, these findings describe heretofore unappreciated curcumin toxicity with potential implications for endothelial growth, development, and tissue healing. Published by Elsevier Ltd. C1 [Jackson, Steven J. T.; Young, Andrew J.] USA, Environm Med Res Inst, Mil Nutr Div, Natick, MA 01760 USA. [Murphy, Laura L.] So Illinois Univ, Dept Physiol, Carbondale, IL 62901 USA. [Venema, Richard C.] Med Coll Georgia, Vasc Biol Ctr, Augusta, GA 30912 USA. [Singletary, Keith W.] Univ Illinois, Dept Food Sci & Human Nutr, Urbana, IL 61801 USA. RP Jackson, SJT (reprint author), USA, Environm Med Res Inst, Mil Nutr Div, 15 Kansas St, Natick, MA 01760 USA. EM steven.jackson25@us.army.mil FU NHLBI NIH HHS [R01 HL108719] NR 42 TC 8 Z9 9 U1 1 U2 13 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0278-6915 J9 FOOD CHEM TOXICOL JI Food Chem. Toxicol. PD OCT PY 2013 VL 60 BP 431 EP 438 DI 10.1016/j.fct.2013.08.008 PG 8 WC Food Science & Technology; Toxicology SC Food Science & Technology; Toxicology GA 228ZN UT WOS:000325231700053 PM 23939039 ER PT J AU Shrestha, M Sridhara, SK Leo, LJ Coppit, GL Ehrhardt, NM AF Shrestha, Merica Sridhara, Shankar K. Leo, Leonard J. Coppit, George L., III Ehrhardt, Nicole M. TI Primary squamous cell carcinoma of the thyroid gland: A case report and review SO HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK LA English DT Article DE thyroid; squamous cell carcinoma; diagnosis; treatment; Hashimoto thyroiditis ID DIFFERENTIAL-DIAGNOSIS; ADENOCARCINOMA; EXPRESSION; ORIGIN AB BackgroundPrimary squamous cell carcinoma (SCC) of the thyroid gland is a rare malignancy that presents with advanced disease and poor prognosis. MethodsA 75-year-old woman with a history of Hashimoto thyroiditis presented with 6 months of dysphagia and stridor. Imaging revealed a thyroid mass invading the larynx. Primary SCC of the thyroid was diagnosed by histopathologic and immunohistochemical evaluation. Total thyroidectomy, total laryngectomy, bilateral modified neck dissection, and adjuvant radiotherapy (RT) were performed. Radiologic follow-up at 21 months demonstrated no disease and total length of survival was 31 months. ResultsDespite an aggressive T4aN0M0 tumor, survival in this case was more than double the median survival rate previously reported. Concomitant Hashimoto thyroiditis is rare and histopathologic and immunohistochemical evaluation is imperative for an accurate diagnosis. ConclusionThe case and literature reported here support that a thorough diagnostic workup of primary SCC of the thyroid with aggressive locoregional surgery and adjuvant RT may improve the length of survival. (c) 2012 Wiley Periodicals, Inc.(dagger)Head Neck 35: E299-E303, 2013 C1 [Shrestha, Merica] Dwight D Eisenhower Army Med Ctr, Dept Med, Endocrinol Diabet & Metab Serv, Ft Gordon, GA 30905 USA. [Sridhara, Shankar K.] Dwight D Eisenhower Army Med Ctr, Dept Surg, Otolaryngol Head & Neck Surg Serv, Ft Gordon, GA 30905 USA. [Leo, Leonard J.] Walter Reed Natl Mil Med Ctr, Dept Pathol, Bethesda, MD USA. [Coppit, George L., III] Walter Reed Natl Mil Med Ctr, Dept Surg, Otolaryngol Head & Neck Surg Serv, Bethesda, MD USA. [Ehrhardt, Nicole M.] Ft Belvoir Community Hosp, Dept Med, Endocrinol Diabet & Metab Serv, Ft Belvoir, VA USA. RP Shrestha, M (reprint author), Dwight D Eisenhower Army Med Ctr, Dept Med, Endocrinol Diabet & Metab Serv, 300 Hosp Rd, Ft Gordon, GA 30905 USA. EM mericashrestha1@gmail.com NR 28 TC 4 Z9 4 U1 0 U2 4 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1043-3074 J9 HEAD NECK-J SCI SPEC JI Head Neck-J. Sci. Spec. Head Neck PD OCT PY 2013 VL 35 IS 10 BP E299 EP E303 DI 10.1002/hed.23152 PG 5 WC Otorhinolaryngology; Surgery SC Otorhinolaryngology; Surgery GA 227EB UT WOS:000325091000002 PM 23002023 ER PT J AU Ferraro, B Talbott, KT Balakrishnan, A Cisper, N Morrow, MP Hutnick, NA Myles, DJ Shedlock, DJ Obeng-Adjei, N Yan, J Kayatani, AKK Richie, N Cabrera, W Shiver, R Khan, AS Brown, AS Yang, M Wille-Reece, U Birkett, AJ Sardesai, NY Weiner, DB AF Ferraro, B. Talbott, K. T. Balakrishnan, A. Cisper, N. Morrow, M. P. Hutnick, N. A. Myles, D. J. Shedlock, D. J. Obeng-Adjei, N. Yan, J. Kayatani, A. K. K. Richie, N. Cabrera, W. Shiver, R. Khan, A. S. Brown, A. S. Yang, M. Wille-Reece, U. Birkett, A. J. Sardesai, N. Y. Weiner, D. B. TI Inducing Humoral and Cellular Responses to Multiple Sporozoite and Liver-Stage Malaria Antigens Using Exogenous Plasmid DNA SO INFECTION AND IMMUNITY LA English DT Article ID CIRCUMSPOROZOITE PROTEIN; PLASMODIUM-FALCIPARUM; IMMUNE-RESPONSES; RHESUS MACAQUES; T-CELLS; YOELII SPOROZOITES; ANTIBODY-RESPONSES; GAMMA-INTERFERON; VACCINE; ELECTROPORATION AB A vaccine candidate that elicits humoral and cellular responses to multiple sporozoite and liver-stage antigens may be able to confer protection against Plasmodium falciparum malaria; however, a technology for formulating and delivering such a vaccine has remained elusive. Here, we report the preclinical assessment of an optimized DNA vaccine approach that targets four P. falciparum antigens: circumsporozoite protein (CSP), liver stage antigen 1 (LSA1), thrombospondin-related anonymous protein (TRAP), and cell-traversal protein for ookinetes and sporozoites (CelTOS). Synthetic DNA sequences were designed for each antigen with modifications to improve expression and were delivered using in vivo electroporation (EP). Immunogenicity was evaluated in mice and nonhuman primates (NHPs) and assessed by enzyme-linked immunosorbent assay (ELISA), gamma interferon (IFN-gamma) enzyme-linked immunosorbent spot (ELISpot) assay, and flow cytometry. In mice, DNA with EP delivery induced antigen-specific IFN-gamma production, as measured by ELISpot assay and IgG seroconversion against all antigens. Sustained production of IFN-gamma, interleukin-2, and tumor necrosis factor alpha was elicited in both the CD4(+) and CD8(+) T cell compartments. Furthermore, hepatic CD8(+) lymphocytes produced LSA1-specific IFN-gamma. The immune responses conferred to mice by this approach translated to the NHP model, which showed cellular responses by ELISpot assay and intracellular cytokine staining. Notably, antigen-specific CD8(+) granzyme B+ T cells were observed in NHPs. Collectively, the data demonstrate that delivery of gene sequences by DNA/EP encoding malaria parasite antigens is immunogenic in animal models and can harness both the humoral and cellular arms of the immune system. C1 [Ferraro, B.; Talbott, K. T.; Balakrishnan, A.; Cisper, N.; Hutnick, N. A.; Myles, D. J.; Shedlock, D. J.; Obeng-Adjei, N.; Shiver, R.; Weiner, D. B.] Univ Penn, Sch Med, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA. [Wille-Reece, U.; Birkett, A. J.] PATH Malaria Vaccine Initiat, Washington, DC USA. [Morrow, M. P.; Yan, J.; Khan, A. S.; Brown, A. S.; Yang, M.; Sardesai, N. Y.] Inovio Pharmaceut Inc, Blue Bell, PA USA. [Kayatani, A. K. K.; Richie, N.; Cabrera, W.] Walter Reed Army Inst Res, US Mil Malaria Vaccine Program, Div Malaria Vaccine Branch, Silver Spring, MD USA. RP Weiner, DB (reprint author), Univ Penn, Sch Med, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA. EM dbweiner@mail.med.upenn.edu RI Weiner, David/H-8579-2014 FU PATH Malaria Vaccine Initiative; National Institutes of Health (NIH) [T32AI070099]; Inovio; BMS; Pfizer; VGXi; Virxsys; J J; Merck; Sanofi Pasteur; Althea; Novo Nordisk; SSI; Aldevron; Novartis; Incyte FX This work was supported by funding from the PATH Malaria Vaccine Initiative and the National Institutes of Health (NIH grant T32AI070099).; D.B.W. and his laboratory have several commercial relationships. He has received consulting fees and stock ownership for Advisory Board/Review Board Service, speaking support, and research support from commercial entities, including Inovio, BMS, Pfizer, VGXi, Virxsys, J & J, Merck, Sanofi Pasteur, Althea, Novo Nordisk, SSI, Aldevron, Novartis, Incyte, and possibly others. No writing assistance was utilized in the production of the manuscript. N.Y.S., M.P.M., A.S.B., A.S.K., J.Y., and M.Y. are employees of Inovio Pharmaceuticals, Inc., and as such receive a salary and own stock/stock options in the company. The other authors declare no conflict of interest. NR 59 TC 16 Z9 16 U1 4 U2 24 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0019-9567 J9 INFECT IMMUN JI Infect. Immun. PD OCT PY 2013 VL 81 IS 10 BP 3709 EP 3720 DI 10.1128/IAI.00180-13 PG 12 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 219SF UT WOS:000324528700022 PM 23897618 ER PT J AU Alaro, JR Partridge, A Miura, K Diouf, A Lopez, AM Angov, E Long, CA Burns, JM AF Alaro, James R. Partridge, Andrea Miura, Kazutoyo Diouf, Ababacar Lopez, Ana M. Angov, Evelina Long, Carole A. Burns, James M., Jr. TI A Chimeric Plasmodium falciparum Merozoite Surface Protein Vaccine Induces High Titers of Parasite Growth Inhibitory Antibodies SO INFECTION AND IMMUNITY LA English DT Article ID CARBOXYL-TERMINAL FRAGMENT; STAGE MALARIA VACCINE; PROTECTIVE IMMUNE-RESPONSES; FACTOR-LIKE DOMAINS; B-CELL EPITOPES; T-CELL; CPG OLIGODEOXYNUCLEOTIDE; RECOMBINANT PROTEIN; CHALLENGE INFECTION; ESCHERICHIA-COLI AB The C-terminal 19-kDa domain of Plasmodium falciparum merozoite surface protein 1 (PfMSP1(19)) is an established target of protective antibodies. However, clinical trials of PfMSP1(42), a leading blood-stage vaccine candidate which contains the protective epitopes of PfMSP1(19), revealed suboptimal immunogenicity and efficacy. Based on proof-of-concept studies in the Plasmodium yoelii murine model, we produced a chimeric vaccine antigen containing recombinant PfMSP1(19) (rPfMSP1(19)) fused to the N terminus of P. falciparum merozoite surface protein 8 that lacked its low-complexity Asn/Asp-rich domain, rPfMSP8 (Delta Asn/Asp). Immunization of mice with the chimeric rPfMSP1/8 vaccine elicited strong T cell responses to conserved epitopes associated with the rPfMSP8 (Delta Asn/Asp) fusion partner. While specific for PfMSP8, this T cell response was adequate to provide help for the production of high titers of antibodies to both PfMSP1(19) and rPfMSP8 (Delta Asn/Asp) components. This occurred with formulations adjuvanted with either Quil A or with Montanide ISA 720 plus CpG oligodeoxynucleotide (ODN) and was observed in both inbred and outbred strains of mice. PfMSP1/8-induced antibodies were highly reactive with two major alleles of PfMSP1(19) (FVO and 3D7). Of particular interest, immunization with PfMSP1/8 elicited higher titers of PfMSP1(19)-specific antibodies than a combined formulation of rPfMSP1(42) and rPfMSP8 (Delta Asn/Asp). As a measure of functionality, PfMSP1/8-specific rabbit IgG was shown to potently inhibit the in vitro growth of blood-stage parasites of the FVO and 3D7 strains of P. falciparum. These data support the further testing and evaluation of this chimeric PfMSP1/8 antigen as a component of a multivalent vaccine for P. falciparum malaria. C1 [Alaro, James R.; Partridge, Andrea; Lopez, Ana M.; Long, Carole A.; Burns, James M., Jr.] Drexel Univ, Coll Med, Ctr Mol Parasitol, Dept Microbiol & Immunol, Philadelphia, PA 19104 USA. [Alaro, James R.; Miura, Kazutoyo; Diouf, Ababacar; Long, Carole A.] NIAID, Malaria Immunol Sect, Lab Malaria & Vector Res, NIH, Rockville, MD USA. [Angov, Evelina] Walter Reed Army Inst Res, US Mil Malaria Res Program, Malaria Vaccine Branch, Silver Spring, MD USA. RP Burns, JM (reprint author), Drexel Univ, Coll Med, Ctr Mol Parasitol, Dept Microbiol & Immunol, Philadelphia, PA 19104 USA. EM jburns@drexelmed.edu FU NIH-NIAID [AI035661]; PATH Malaria Vaccine Initiative FX This work was supported by NIH-NIAID grant AI035661 (J.M.B.) and the Intramural Program of NIH-NIAID (C.A.L.). The GIA Reference Center where the GIA assay was performed is supported by the PATH Malaria Vaccine Initiative. NR 73 TC 6 Z9 6 U1 0 U2 7 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0019-9567 J9 INFECT IMMUN JI Infect. Immun. PD OCT PY 2013 VL 81 IS 10 BP 3843 EP 3854 DI 10.1128/IAI.00522-13 PG 12 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 219SF UT WOS:000324528700035 PM 23897613 ER PT J AU Liu, NT Batchinsky, AI Cancio, LC Baker, WL Salinas, J AF Liu, Nehemiah T. Batchinsky, Andriy I. Cancio, Leopoldo C. Baker, William L., Jr. Salinas, Jose TI Development and validation of a novel fusion algorithm for continuous, accurate, and automated R-wave detection and calculation of signal-derived metrics SO JOURNAL OF CRITICAL CARE LA English DT Article DE Signal detection analysis; Heart rate complexity; Electrocardiography; Clinical decision support systems; Automatic data processing ID QRS DETECTION; CARDIOLOGY CHALLENGE; ATRIAL-FIBRILLATION; TRAUMA PATIENTS; PHYSIONET/COMPUTERS; COMPUTERS; COMPLEXITY; TRANSFORMS; MORTALITY; FILTER AB Purpose: Previous studies have shown that heart rate complexity may be a useful indicator of patient status in the critical care environment but will require continuous, accurate, and automated R-wave detection (RWD) in the electrocardiogram (ECG). Although numerous RWD algorithms exist, accurate detection remains a challenge. The purpose of this study was to develop and validate a novel fusion algorithm (Automated Electrocardiogram Selection of Peaks, or AESOP) that combines the strengths of several well-known algorithms to provide a more reliable real-time solution to the RWD problem. Materials and Methods: This study involved the ECGs of 108 prehospital patient records and 32 ECGs from a conscious sedated porcine model of hemorrhagic shock. The criterion standard for validation was manual verification of R waves. Results: For 108 human ECG records, the AESOP algorithm overall outperformed each of its component algorithms. In addition, for 32 swine ECG records, AESOP achieved an R-wave sensitivity of 97.9% and a positive predictive value of 97.5%, again outperforming its component algorithms. Conclusion: By fusing several best algorithms, AESOP uses the strengths of each algorithm to perform more robustly and reliably in real time. The AESOP algorithm will be integrated into a real-time heart rate complexity software program for decision support and triage in critically ill patients. (C) 2013 Elsevier Inc. All rights reserved. C1 [Liu, Nehemiah T.; Batchinsky, Andriy I.; Cancio, Leopoldo C.; Baker, William L., Jr.; Salinas, Jose] US Army, Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Liu, NT (reprint author), US Army, Inst Surg Res, Ft Sam Houston, TX 78234 USA. EM nehemiah.liu@us.army.mil FU US Army Institute of Surgical Research (Comprehensive Intensive Care Research Task Area and the Combat Casualty Care Research Program) FX This work was supported by the US Army Institute of Surgical Research (Comprehensive Intensive Care Research Task Area and the Combat Casualty Care Research Program). NR 30 TC 4 Z9 4 U1 0 U2 11 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0883-9441 J9 J CRIT CARE JI J. Crit. Care PD OCT PY 2013 VL 28 IS 5 AR 885.e9 DI 10.1016/j.jcrc.2013.02.015 PG 10 WC Critical Care Medicine SC General & Internal Medicine GA 217QM UT WOS:000324374700065 PM 23618780 ER PT J AU Pathak, C Curtis, D Kitzmiller, D Vieux, B AF Pathak, Chandra Curtis, David Kitzmiller, David Vieux, Baxter TI Identifying and Resolving the Barriers and Issues in Using Radar-Derived Rainfall Estimating Technology SO JOURNAL OF HYDROLOGIC ENGINEERING LA English DT Article ID REAL-TIME ESTIMATION; WSR-88D; BIAS C1 [Pathak, Chandra] US Army, Corps Engineers, Washington, DC 20314 USA. [Curtis, David] West Consultants, Folsom, CA 95630 USA. [Kitzmiller, David] NOAA, Hydrol Sci & Modeling Branch, Off Hydrol Dev, Natl Weather Serv, Silver Spring, MD 20910 USA. [Vieux, Baxter] Univ Oklahoma, Sch Civil Engn & Environm Sci, Norman, OK 73072 USA. [Vieux, Baxter] Univ Oklahoma, Ctr Nat Hazards & Disaster Res, Norman, OK 73072 USA. RP Pathak, C (reprint author), US Army, Corps Engineers, 441 G St NW, Washington, DC 20314 USA. EM chandra.s.pathak@usace.army.mil; dcurtis@westconsultants.com; David.Kitzmiller@noaa.gov; bvieuex@ou.edu OI Vieux, Baxter/0000-0001-8814-4380 NR 42 TC 0 Z9 0 U1 1 U2 2 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 1084-0699 EI 1943-5584 J9 J HYDROL ENG JI J. Hydrol. Eng. PD OCT 1 PY 2013 VL 18 IS 10 BP 1193 EP 1199 DI 10.1061/(ASCE)HE.1943-5584.0000766 PG 7 WC Engineering, Civil; Environmental Sciences; Water Resources SC Engineering; Environmental Sciences & Ecology; Water Resources GA 218XT UT WOS:000324466700002 ER PT J AU Alexson, DA Smith, DD AF Alexson, Dimitri A. Smith, Doran D. TI NMR spectroscopy with force-gradient detection on a GaAs epitaxial layer SO JOURNAL OF MAGNETIC RESONANCE LA English DT Article DE MRFM; Force-gradient detected NMR; NMR microscopy; GaAs ID NUCLEAR-MAGNETIC-RESONANCE; FIBEROPTIC INTERFEROMETER; MICROSCOPY; PROBE AB We demonstrate nuclear magnetic resonance spectroscopy on 35 mu m(3) of Ga-69 in a GaAs epitaxial layer in vacuum at 5 K, and 5 T yielding a linewidth on the order of 10 kHz. This was achieved by a force-gradient magnetic resonance detection scheme, using the interaction between the force-gradient of a Ni spheretipped single crystal Si cantilever and the nuclear spins to register changes in the spin state as a change in the driven cantilever's natural resonant frequency. The dichotomy between the background magnetic field (B-0) homogeneity requirements imposed by NMR spectroscopy and the magnetic particle's large magnetic field gradient is resolved via sample shuttling during the NMR pulse encoding. A GaAs sample is polarized in a B-0 of 5 T for 3 (*) T-1. The sample is shuttled away from the magnetic particle to a region of negligible magnetic field inhomogeneity. A (pi/2)(x) pulse rotates the polarization to the xy-plane, the magnetization is allowed to precess for 2-200 mu s before a (pi/2)(x) or (pi/2)(x) pulse stores the remaining spin along the z-axis that represents a single point of the free induction decay (FID). The sample is shuttled back to the established tip-sample distance. An adiabatic rapid passage (ARP) sweep inverts the spins in a volume of interest, causing the cantilever's natural resonance frequency to shift an amount proportional to the spin polarization in the volume. By varying the delay between the first and second (pi/2) pulses the entire FID is measured. (c) 2013 Elsevier Inc. All rights reserved. C1 [Alexson, Dimitri A.; Smith, Doran D.] US Army, Res Lab, Adelphi, MD 20783 USA. RP Alexson, DA (reprint author), US Army, Res Lab, Adelphi, MD 20783 USA. EM dimitri.alexson.ctr@mail.mil FU Office of Defense Nuclear Nonproliferation RD FX The work was partially supported by the Office of Defense Nuclear Nonproliferation R&D. The authors would like to graciously thank Dr. Chris Klug for many helpful NMR discussions, Jeff Pulskamp for modeling the vibration behavior of parts of the probe head, Peter Newman for the GaAs crystal growth, Mathew Erwin for Au coating the sample, and Dr. Nicholas Fell and Dr. Parvez Uppal for their support. NR 16 TC 1 Z9 1 U1 3 U2 18 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 1090-7807 J9 J MAGN RESON JI J. Magn. Reson. PD OCT PY 2013 VL 235 BP 66 EP 70 DI 10.1016/j.jmr.2013.07.013 PG 5 WC Biochemical Research Methods; Physics, Atomic, Molecular & Chemical; Spectroscopy SC Biochemistry & Molecular Biology; Physics; Spectroscopy GA 223XX UT WOS:000324846900009 PM 23962899 ER PT J AU Tate, CM Wang, KKW Eonta, S Zhang, Y Carr, W Tortella, FC Hayes, RL Kamimori, GH AF Tate, Charmaine M. Wang, Kevin K. W. Eonta, Stephanie Zhang, Yang Carr, Walter Tortella, Frank C. Hayes, Ronald L. Kamimori, Gary H. TI Serum Brain Biomarker Level, Neurocognitive Performance, and Self-Reported Symptom Changes in Soldiers Repeatedly Exposed to Low-Level Blast: A Breacher Pilot Study SO JOURNAL OF NEUROTRAUMA LA English DT Article DE blast injury; biomarker; military injury; neurocognitive; symptoms ID FIBRILLARY ACIDIC PROTEIN; C-TERMINAL HYDROLASE; NEUROPSYCHOLOGICAL ASSESSMENT METRICS; SPECTRIN BREAKDOWN PRODUCTS; NEUROSURGICAL INTERVENTION; INTRACRANIAL LESIONS; INJURY PATIENTS; MILD; GFAP; S100B AB Breachers are a unique military and law enforcement population because they are routinely exposed to low-level blast (LLB) during training and operations. This repeated exposure has been associated with symptoms similar to that of sports concussion. This study examined effects of repeated exposure to LLB during an explosive entry course. Twenty-one members of the New Zealand Defence Force volunteered for this study. Serum samples, neurocognitive performance, and self-reported symptoms were periodically measured before, during, and after a 2-week course. Serum concentrations of three biomarkers, ubiquitin C-terminal hydrolase-L1, II-spectrin breakdown product, and glial fibrillary acidic protein, were determined with sandwich enzyme-linked immunosorbent assays, and rank scores were derived using the area under the curve (relative to baseline) for each subject. Neurocognitive performance was measured with a computer-based test battery, and symptoms were assessed by paper-based inventory. There was a significant relationship (p<0.05) between composite biomarker and neurocognitive performance and between neurocognitive performance and symptoms. The individuals with the five highest (Top 5) and lowest (Bottom 5) composite biomarker scores were identified and compared using Wilcoxon's rank-sum test. The Top 5 had significantly longer reaction times and lower percent correct on neurocognitive performance and an increase in symptom reporting. The difference between individuals expressing the highest biomarker load during breacher training (Top 5) and those with the lowest biomarker load (Bottom 5) is reflected in neurocognitive performance deficits and self-reported symptoms. This suggests a measureable degree of brain perturbation linked to LLB exposure. Follow-up studies are underway to expand upon these results. C1 [Tate, Charmaine M.] New Zealand Def Force, Auckland, New Zealand. [Wang, Kevin K. W.; Hayes, Ronald L.] Banyan Biomarkers Inc, Banyan Labs, Alachua, FL USA. [Eonta, Stephanie; Carr, Walter] Naval Med Res Ctr, Silver Spring, MD USA. [Zhang, Yang; Kamimori, Gary H.] Walter Reed Army Inst Res, Dept Behav Biol, Silver Spring, MD USA. [Tortella, Frank C.] Walter Reed Army Inst Res, Brain Trauma Neuroprotect Neurorestorat Branch, Silver Spring, MD USA. [Wang, Kevin K. W.] Univ Florida, Dept Psychiat, Ctr Neuroprote & Biomarker Res, Gainesville, FL 32610 USA. RP Wang, KKW (reprint author), Univ Florida, Dept Psychiat, Ctr Neuroprote & Biomarker Res, 100 South Newell Dr POB 100256, Gainesville, FL 32610 USA. EM kwang@ufl.edu OI Wang, Kevin/0000-0002-9343-6473 FU NZDF; Congressionally Directed Medical Research Program [W81XWH-09-2-0055 of]; RAD III of the U.S. Army Medical Research and Materiel Command FX This work was funded by the NZDF, a grant from the Congressionally Directed Medical Research Program (award no.: W81XWH-09-2-0055 of), and RAD III of the U.S. Army Medical Research and Materiel Command. The authors thank Christina R. LaValle for her statistical support, the contributing New Zealand military unit medical staff, and the staff of the Walter Reed Army Institute of Research and Naval Medical Research Center for their assistance in the completion of this study and the preparation of the manuscript for this article. The opinions and assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the NZDF, the U.S. Army, the U.S. Navy, or of the U.S. DoD. NR 43 TC 25 Z9 26 U1 2 U2 7 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 J9 J NEUROTRAUM JI J. Neurotrauma PD OCT 1 PY 2013 VL 30 IS 19 BP 1620 EP 1630 DI 10.1089/neu.2012.2683 PG 11 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA 227WQ UT WOS:000325146800002 PM 23687938 ER PT J AU Arun, P Abu-Taleb, R Oguntayo, S Wang, Y Valiyaveettil, M Long, JB Nambiar, MP AF Arun, Peethambaran Abu-Taleb, Rania Oguntayo, Samuel Wang, Ying Valiyaveettil, Manojkumar Long, Joseph B. Nambiar, Madhusoodana P. TI Acute Mitochondrial Dysfunction after Blast Exposure: Potential Role of Mitochondrial Glutamate Oxaloacetate Transaminase SO JOURNAL OF NEUROTRAUMA LA English DT Article DE adenosine triphosphate; blast exposure; glutamate oxaloacetate transaminase; mini citric acid cycle; mitochondrial dysfunction; pyruvate dehydrogenase; traumatic brain injury ID TRAUMATIC BRAIN-INJURY; N-ACETYLASPARTATE; RAT-BRAIN; INDUCED NEUROTRAUMA; OVERPRESSURE; METABOLISM; SEVERITY; MODEL AB Use of improvised explosive devices has significantly increased the incidence of traumatic brain injury (TBI) and associated neuropsychiatric deficits in the recent wars in Iraq and Afghanistan. Acute deleterious effects of single and repeated blast exposure can lead to long-term neurobiological effects and neuropsychiatric deficits. Using in vitro and in vivo shock tube models of blast-induced TBI, we studied changes in mitochondrial energy metabolism after blast exposure. Single and repeated blast exposures in vitro resulted in significant decreases in neuronal adenosine triphosphate (ATP) levels at 6h post-blast that returned towards normal levels by 24h. Similar changes in ATP also were observed in the cerebral cortices of mice subjected to single and repeated blast exposures. In neurons, mitochondrial glutamate oxaloacetate transaminase (GOT(2)) plays a critical role in metabolism and energy production. Proteomic analysis of brain cortices showed a significant decrease in GOT(2) levels 6h after repeated blast exposures, which was further confirmed by Western blotting. Western blot analysis of GOT(2) and pyruvate dehydrogenase in the cortex showed direct correlation only between GOT(2) and ATP levels. Activity of GOT(2) in the isolated cortical mitochondria also showed significant decrease at 6h supporting the results of proteomic and Western blot analyses. Knowing the significant role of GOT(2) in the neuronal mitochondrial energy metabolism, it is quite likely that the down regulation of GOT(2) after blast exposure is playing a significant role in mitochondrial dysfunction after blast exposure. C1 [Arun, Peethambaran; Abu-Taleb, Rania; Oguntayo, Samuel; Wang, Ying; Valiyaveettil, Manojkumar; Long, Joseph B.; Nambiar, Madhusoodana P.] Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci, Blast Induced Neurotrauma Branch, Silver Spring, MD 20910 USA. RP Arun, P (reprint author), Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci, Blast Induced Neurotrauma Branch, Silver Spring, MD 20910 USA. EM peethambaran.arun.ctr@mail.mil NR 30 TC 5 Z9 9 U1 0 U2 4 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 J9 J NEUROTRAUM JI J. Neurotrauma PD OCT 1 PY 2013 VL 30 IS 19 BP 1645 EP 1651 DI 10.1089/neu.2012.2834 PG 7 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA 227WQ UT WOS:000325146800005 PM 23600763 ER PT J AU Goss, DL Gross, MT AF Goss, Donald Lee Gross, Michael T. TI A Comparison of Negative Joint Work and Vertical Ground Reaction Force Loading Rates in Chi Runners and Rearfoot-Striking Runners SO JOURNAL OF ORTHOPAEDIC & SPORTS PHYSICAL THERAPY LA English DT Article DE ankle; barefoot; impact; knee; minimalist ID INJURY REDUCTION EFFECTIVENESS; TIBIAL STRESS-FRACTURE; DISTANCE RUNNERS; FEMALE RUNNERS; PATELLOFEMORAL PAIN; STRIDE LENGTHS; PLANTAR SHAPE; PATTERNS; KNEE; FREQUENCY AB STUDY DESIGN: Observational. OBJECTIVES: To compare lower extremity negative joint work and vertical ground reaction force loading rates in rearfoot-striking (RS) and Chi runners. BACKGROUND: Alternative running styles such as Chi running have become a popular alternative to RS running. Proponents assert that this running style reduces knee joint loading and ground reaction force loading rates. METHODS: Twenty-two RS and 12 Chi runners ran for 5 minutes at a self-selected speed on an instrumented treadmill. A 3-D motion analysis system was used to obtain kinematic data. Average vertical ground reaction force loading rate and negative work of the ankle dorsiflexors, ankle plantar flexors, and knee extensors were computed during the stance phase. Groups were compared using a 1-way analysis of covariance for each variable, with running speed and age as covariates. RESULTS: On average, RS runners demonstrated greater knee extensor negative work (RS, -0.332 J/body height x body weight [BMW]; Chi, -0.144 J/BH.BW; P<.001), whereas Chi runners demonstrated more ankle plantar flexor negative work (Chi, -0.467 J/BH.BW; RS, -0.315 J/BH-BW; P<.001). RS runners demonstrated greater average vertical ground reaction force loading rates than Chi runners (RS, 68.6 BW/s; Chi, 43.1 BW/s; P<.001). CONCLUSION: Chi running may reduce vertical loading rates and knee extensor work, but may increase work of the ankle plantar flexors. C1 [Goss, Donald Lee] US Army Baylor Univ Doctoral Program Phys Therapy, Ft Sam Houston, TX USA. [Gross, Michael T.] Univ N Carolina, Div Phys Therapy, Program Human Movement Sci, Chapel Hill, NC USA. RP Goss, DL (reprint author), 3599 Winfield Scott Rd,Suite 1301, Ft Sam Houston, TX 78234 USA. EM donald.l.goss.mil@mail.mil NR 49 TC 11 Z9 11 U1 2 U2 22 PU J O S P T, PI ALEXANDRIA PA 1111 NORTH FAIRFAX ST, STE 100, ALEXANDRIA, VA 22314-1436 USA SN 0190-6011 J9 J ORTHOP SPORT PHYS JI J. Orthop. Sports Phys. Ther. PD OCT PY 2013 VL 43 IS 10 BP 685 EP 692 DI 10.2519/jospt.2013.4542 PG 8 WC Orthopedics; Rehabilitation; Sport Sciences SC Orthopedics; Rehabilitation; Sport Sciences GA 229YD UT WOS:000325302900002 PM 24256170 ER PT J AU Glenesk, K Fogarty, BT Westrick, RB AF Glenesk, Kathleen Fogarty, Brian T. Westrick, Richard B. TI Isolated Posterior Cruciate Ligament Injury SO JOURNAL OF ORTHOPAEDIC & SPORTS PHYSICAL THERAPY LA English DT Editorial Material C1 [Glenesk, Kathleen] Keller Army Community Hosp, Arvin Sports Phys Therapy Clin, West Point, NY USA. [Fogarty, Brian T.] Keller Army Community Hosp, West Point, NY USA. [Westrick, Richard B.] US Army Baylor Univ Doctoral Residency Sports Phy, West Point, NY USA. RP Glenesk, K (reprint author), Keller Army Community Hosp, Arvin Sports Phys Therapy Clin, West Point, NY USA. NR 3 TC 0 Z9 0 U1 0 U2 4 PU J O S P T, PI ALEXANDRIA PA 1111 NORTH FAIRFAX ST, STE 100, ALEXANDRIA, VA 22314-1436 USA SN 0190-6011 J9 J ORTHOP SPORT PHYS JI J. Orthop. Sports Phys. Ther. PD OCT PY 2013 VL 43 IS 10 BP 759 EP 759 DI 10.2519/jospt.2013.0418 PG 1 WC Orthopedics; Rehabilitation; Sport Sciences SC Orthopedics; Rehabilitation; Sport Sciences GA 229YD UT WOS:000325302900010 PM 24256175 ER PT J AU Sablon, KA Sergeev, A Vagidov, N Little, JW Mitin, V AF Sablon, Kimberly A. Sergeev, Andrei Vagidov, Nizami Little, John W. Mitin, Vladimir TI Effects of quantum dot charging on photoelectron processes and solar cell characteristics SO SOLAR ENERGY MATERIALS AND SOLAR CELLS LA English DT Article DE Quantum dot solar cell; IR harvesting; Selective doping; Potential barrier ID BUILT-IN CHARGE; CARRIER-RELAXATION; EFFICIENCY; OPERATION; CAPTURE AB We present theoretical and experimental analysis of photocarrier kinetics in quantum dot (QD) solar cells. The measurements of the J-V characteristics reveal strong effects of QD charging by selective doping of the interdot space on the solar cell characteristics. We demonstrate that charging of QDs significantly increases electron coupling to sub-bandgap photons, provides effective harvesting of IR energy, and serve as an effective tool for manipulating the potential profile at the micro- and nanoscale. The potential well for electrons in InAs QDs is substantially deeper than that for holes and, due to major differences between the effective masses of electrons and holes, the electron level spacing is substantially larger than the level spacing for holes. Therefore, QDs act as deep traps for electrons but shallow traps for holes. Filling of QDs under illumination is determined by a condition of equality of electron and hole capture rates which is realized via strong exponential dependence of the capture rates on the potential barrier around a charged dot. Without adequate doping of the QD medium, QDs are filled by electrons from the n-doped junction area and deteriorate the solar cell performance. However, selective n-doping of the QD medium results in micro- and nanoscale potential profiles favorable for photovoltaic conversion. Potential barriers around charged QDs decrease the photoelectron capture processes and suppress recombination processes via QDs. The filling of QDs predominantly from dopants in the QD medium allows one to maintain the microscale potential profile analogous to that in the best conventional single-junction solar cells. (C) 2012 Elsevier B.V. All rights reserved. C1 [Sablon, Kimberly A.; Little, John W.] US Army Res Lab, Adelphi, MD 20783 USA. [Sergeev, Andrei; Vagidov, Nizami; Mitin, Vladimir] SUNY Buffalo, Buffalo, NY 14260 USA. [Vagidov, Nizami] Optoelect Nanodevices LLC, Amherst, NY 14226 USA. RP Sablon, KA (reprint author), US Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM ksablon@gmail.com FU Air Force Office of Scientific Research (AFOSR); NSF DMR [0907126]; NSF SBIR [1215033] FX This work was partially supported by Air Force Office of Scientific Research (AFOSR). The research of A.S. was also supported by the NSF DMR under Grant no. 0907126. The research of N.V. was supported by NSF SBIR under Grant no. 1215033. NR 31 TC 10 Z9 10 U1 0 U2 15 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0927-0248 EI 1879-3398 J9 SOL ENERG MAT SOL C JI Sol. Energy Mater. Sol. Cells PD OCT PY 2013 VL 117 SI SI BP 638 EP 644 DI 10.1016/j.solmat.2012.10.002 PG 7 WC Energy & Fuels; Materials Science, Multidisciplinary; Physics, Applied SC Energy & Fuels; Materials Science; Physics GA 228LN UT WOS:000325188400096 ER PT J AU Vega, S Marciscano, I Holcomb, M Erps, KA Major, J Lopez, AM Barker, GP Weinstein, RS AF Vega, Silvio Marciscano, Ivette Holcomb, Michael Erps, Kristine A. Major, Janet Lopez, Ana Maria Barker, Gail P. Weinstein, Ronald S. TI Testing a Top-Down Strategy for Establishing a Sustainable Telemedicine Program in a Developing Country: The Arizona Telemedicine Program-U.S. Army-Republic of Panama Initiative SO TELEMEDICINE AND E-HEALTH LA English DT Article DE extreme environments; policy; telecardiology; teledermatology; tele-emergency medicine; telehealth; tele-infectious disease; telemedicine; tele-obstetrics; telepulmonology; teleradiology ID FORWARD TELEMEDICINE; DEVELOPING-WORLD; HEALTH-CARE; TELEPATHOLOGY; CAMBODIA; SUCCESS AB Objective:Many developing countries have shown interest in embracing telemedicine and incorporating it into their healthcare systems. In 2000, the U.S. Army Yuma Proving Ground (YPG) initiated a program to assist the Republic of Panama in establishing a demonstration Panamanian rural telemedicine program. YPG engaged the Arizona Telemedicine Program (ATP) to participate in the development and implementation of the program.Materials and Methods:The ATP recommended adoption of a top-down strategy for creating the program. Early buy-in of the Panamanian Ministry of Health and academic leaders was regarded as critical to the achievement of long-term success.Results:High-level meetings with the Minister of Health and the Rectors (i.e., Presidents) of the national universities gained early program support. A telemedicine demonstration project was established on a mountainous Indian reservation 230 miles west of Panama City. Today, three rural telemedicine clinics are linked to a regional Ministry of Health hospital for teleconsultations. Real-time bidirectional videoconferencing utilizes videophones connected over Internet protocol networks at a data rate of 768 kilobits per second to the San Felix Hospital. Telepediatrics, tele-obstetrics, telepulmonology, teledermatology, and tele-emergency medicine services became available. Telemedicine services were provided to the three sites for a total of 1,013 cases, with numbers of cases increasing each year. These three demonstration sites remained in operation after discontinuation of the U.S. involvement in September 2009 and serve as a model program for other telemedicine initiatives in Panama.Conclusions:Access to the assets of a partner-nation was invaluable in the establishment of the first model telemedicine demonstration program in Panama. After 3 years, the Panamanian Telemedicine and Telehealth Program (PTTP) became self-sufficient. The successful achievement of sustainability of the PTTP after disengagement by the United States fits the Latifi-Weinstein model for establishing telemedicine programs in developing countries. C1 [Vega, Silvio] Latin Amer Univ Sci & Technol, Sch Med, Panama City, Panama. [Vega, Silvio; Marciscano, Ivette] US Army Yuma Proving Ground, Yuma, AZ USA. [Vega, Silvio; Marciscano, Ivette; Lopez, Ana Maria; Weinstein, Ronald S.] Univ Arizona, Coll Med Tucson, Tucson, AZ USA. [Vega, Silvio; Marciscano, Ivette; Holcomb, Michael; Erps, Kristine A.; Major, Janet; Lopez, Ana Maria; Barker, Gail P.; Weinstein, Ronald S.] Arizona Telemed Program, Tucson, AZ USA. [Marciscano, Ivette] Univ Panama, Sch Nursing, Panama City, Panama. [Barker, Gail P.; Weinstein, Ronald S.] T Hlth Inst, Phoenix, AZ USA. [Barker, Gail P.; Weinstein, Ronald S.] Univ Arizona, Coll Med Phoenix, Phoenix, AZ USA. RP Weinstein, RS (reprint author), Univ Arizona Hlth Network, Arizona Telemed Program, 1501 North Campbell Ave, Tucson, AZ 85724 USA. EM rweinstein@telemedicine.arizona.edu OI Lopez, Ana Maria/0000-0002-2759-5353 FU U.S. Army Yuma Proving Grounds; U.S. Department of Defense FX This ATP work effort was supported through a series of contracts from the U.S. Army Yuma Proving Grounds entitled "Intellectual Technical Support Services for Biological and Tropical Sciences," U.S. Department of Defense (2001-2009). We also thank Dr. Rifat Latifi for useful collaborations on the development of strategies for implementing telemedicine in developing countries and Dr. Anna R. Graham for useful suggestions and for editing the manuscript. NR 37 TC 5 Z9 5 U1 0 U2 17 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1530-5627 J9 TELEMED E-HEALTH JI Telemed. e-Health PD OCT 1 PY 2013 VL 19 IS 10 BP 746 EP 753 DI 10.1089/tmj.2013.0025 PG 8 WC Health Care Sciences & Services SC Health Care Sciences & Services GA 227RU UT WOS:000325132300004 PM 23931731 ER PT J AU Kang, GY Parks, JR Fileta, B Chang, A Abdel-Rahim, MM Burch, HB Bernet, VJ AF Kang, Grace Y. Parks, Jonathan R. Fileta, Bader Chang, Audrey Abdel-Rahim, Maged M. Burch, Henry B. Bernet, Victor J. TI Thyroxine and Triiodothyronine Content in Commercially Available Thyroid Health Supplements SO THYROID LA English DT Article ID LIQUID-CHROMATOGRAPHY; DIETARY-SUPPLEMENT; MEDICINES; HYPERTHYROIDISM; THYROTOXICOSIS; LEVOTHYROXINE AB Background: As defined by the Dietary Supplement Health and Education Act 1997, such substances as herbs and dietary supplements fall under general Food and Drug Administration supervision but have not been closely regulated to date. We examined the thyroid hormone content in readily available dietary health supplements marketed for thyroid support. Methods: Ten commercially available thyroid dietary supplements were purchased. Thyroid supplements were dissolved in 10mL of acetonitrile and water with 0.1% trifloroacetic acid and analyzed using high-performance liquid chromatography for the presence of both thyroxine (T4) and triiodothyronine (T3) using levothyroxine and liothyronine as a positive controls and standards. Results: The amount of T4 and T3 was measured separately for each supplement sample. Nine out of 10 supplements revealed a detectable amount of T3 (1.3-25.4g/tablet) and 5 of 10 contained T4 (5.77-22.9g/tablet). Taken at the recommended dose, 5 supplements delivered T3 quantities of greater than 10g/day, and 4 delivered T4 quantities ranging from 8.57 to 91.6g/day. Conclusions: The majority of dietary thyroid supplements studied contained clinically relevant amounts of T4 and T3, some of which exceeded common treatment doses for hypothyroidism. These amounts of thyroid hormone, found in easily accessible dietary supplements, potentially expose patients to the risk of alterations in thyroid levels even to the point of developing iatrogenic thyrotoxicosis. The current study results emphasize the importance of patient and provider education regarding the use of dietary supplements and highlight the need for greater regulation of these products, which hold potential danger to public health. C1 [Kang, Grace Y.] Landstuhl Reg Med Ctr, Dept Endocrinol, D-09180 Landstuhl, Germany. [Parks, Jonathan R.] Tripler Army Med Ctr, Dept Endocrinol, Honolulu, HI 96859 USA. [Fileta, Bader; Chang, Audrey; Abdel-Rahim, Maged M.] Walter Reed Natl Mil Med Ctr, Dept Clin Invest, Bethesda, MD USA. [Burch, Henry B.] Walter Reed Natl Mil Med Ctr, Div Endocrinol & Metab, Bethesda, MD USA. [Bernet, Victor J.] Mayo Clin, Div Endocrinol Metab & Nutr, Jacksonville, FL 32224 USA. RP Kang, GY (reprint author), Landstuhl Reg Med Ctr, Div Med, Dept Endocrinol, APO AE, CMR 402, D-09180 Landstuhl, Germany. EM grace.y.kang.mil@mail.mil FU Henry M. Jackson Foundation FX The authors acknowledge the Henry M. Jackson Foundation for supporting study funds. NR 21 TC 9 Z9 9 U1 0 U2 8 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1050-7256 J9 THYROID JI Thyroid PD OCT 1 PY 2013 VL 23 IS 10 BP 1233 EP 1237 DI 10.1089/thy.2013.0101 PG 5 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA 223TE UT WOS:000324832100008 PM 23758055 ER PT J AU Ravis, WR Llanos-Cuentas, A Sosa, N Kreishman-Deitrick, M Kopydlowski, KM Nielsen, C Smith, KS Smith, PL Ransom, JH Lin, YJ Groglf, M AF Ravis, William R. Llanos-Cuentas, Alejandro Sosa, Nestor Kreishman-Deitrick, Mara Kopydlowski, Karen M. Nielsen, Carl Smith, Kirsten S. Smith, Philip L. Ransom, Janet H. Lin, Yuh-Jing Groglf, Max TI Pharmacokinetics and Absorption of Paromomycin and Gentamicin from Topical Creams Used To Treat Cutaneous Leishmaniasis SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY LA English DT Article ID AMINOSIDINE AB This study evaluated the pharmacokinetics of topical creams containing 15% paromomycin ("paromomycin alone") and 15% paromomycin plus 0.5% gentamicin (WR 279,396) in patients with cutaneous leishmaniasis. The investigational creams were applied topically to all lesions once daily for 20 days. Plasma samples were analyzed for simultaneous quantitation of paromomycin and gentamicin isomers and total gentamicin. Pharmacokinetic parameters for gentamicin could not be calculated because detectable levels were rarely evident. After one application, the paromomycin area under the concentration-time curve from 0 to 24 h (AUC(0-24)) was 2,180 +/- 2,621 ng . h/ml (mean +/- standard deviation [SD]) for the paromomycin-alone group and 975.6 +/- 1,078 ng . h/ml for the WR 279,396 group. After 20 days of application, the paromomycin AUC(0-24) and maximum concentration of drug (C-max) were 5 to 6 times greater than those on day 1 for both treatment groups. For the paromomycin-alone group, the AUC(0-24) was 8,575 +/- 7,268 ng . h/ml and the C-max was 1,000 +/- 750 ng/ml, compared with 6,037 +/- 3,956 ng . h/ml and 660 +/- 486 ng/ml for the WR 279,396 group, respectively. Possibly due to large intersubject variability, no differences (P >= 0.05) in the AUC(0-24) or C-max were noted between treatment or between sites on day 1 or 20. The percentage of dose absorbed on day 20 was 12.0% +/- 6.26% and 9.68% +/- 6.05% for paromomycin alone and WR 279,396, respectively. Paromomycin concentrations in plasma after 20 days of application were 5 to 9% of those after intramuscular administration of 15 mg/kg of body weight/day to adults for the systemic treatment of visceral leishmaniasis. Effective topical treatment of cutaneous leishmaniasis appears to be possible with limited paromomycin and gentamicin systemic absorption, thus avoiding drug accumulation and toxicity. (The work described here has been registered at ClinicalTrials.gov under registration no. NCT01032382 and NCT01083576.) C1 [Ravis, William R.; Lin, Yuh-Jing] Auburn Univ, Auburn, AL 36849 USA. [Sosa, Nestor] Inst Conmemorat Gorgas Estudios Salud, Panama City, Panama. [Kreishman-Deitrick, Mara; Kopydlowski, Karen M.; Nielsen, Carl; Smith, Kirsten S.; Smith, Philip L.] US Army, Med Mat Dev Act, Ft Detrick, MD USA. [Ransom, Janet H.] Fast Track Drugs & Biol, North Potomac, MD USA. [Groglf, Max] Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD USA. RP Ravis, WR (reprint author), Auburn Univ, Auburn, AL 36849 USA. EM raviswr@auburn.edu FU Department of the Army FX This work was supported by the Department of the Army. NR 18 TC 4 Z9 4 U1 0 U2 9 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0066-4804 J9 ANTIMICROB AGENTS CH JI Antimicrob. Agents Chemother. PD OCT PY 2013 VL 57 IS 10 BP 4809 EP 4815 DI 10.1128/AAC.00628-13 PG 7 WC Microbiology; Pharmacology & Pharmacy SC Microbiology; Pharmacology & Pharmacy GA 219BU UT WOS:000324480300026 PM 23877689 ER PT J AU Pelletier, MR Casella, LG Jones, JW Adams, MD Zurawski, DV Hazlett, KRO Doi, Y Ernst, RK AF Pelletier, Mark R. Casella, Leila G. Jones, Jace W. Adams, Mark D. Zurawski, Daniel V. Hazlett, Karsten R. O. Doi, Yohei Ernst, Robert K. TI Unique Structural Modifications Are Present in the Lipopolysaccharide from Colistin-Resistant Strains of Acinetobacter baumannii SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY LA English DT Article ID 2-COMPONENT REGULATORY SYSTEM; TANDEM MASS-SPECTROMETRY; GRAM-NEGATIVE BACTERIA; LIPID-A; PHOSPHOETHANOLAMINE MODIFICATION; ANTIMICROBIAL PEPTIDES; DISK DIFFUSION; VIRULENCE; PMRAB; PHOSPHORYLATION AB Acinetobacter baumannii is a nosocomial opportunistic pathogen that can cause severe infections, including hospital-acquired pneumonia, wound infections, and sepsis. Multidrug-resistant (MDR) strains are prevalent, further complicating patient treatment. Due to the increase in MDR strains, the cationic antimicrobial peptide colistin has been used to treat A. baumannii infections. Colistin-resistant strains of A. baumannii with alterations to the lipid A component of lipopolysaccharide (LPS) have been reported; specifically, the lipid A structure was shown to be hepta-acylated with a phosphoethanolamine (pEtN) modification present on one of the terminal phosphate residues. Using a tandem mass spectrometry platform, we provide definitive evidence that the lipid A isolated from colistin-resistant A. baumannii MAC204 LPS contains a novel structure corresponding to a diphosphoryl hepta-acylated lipid A structure with both pEtN and galactosamine (GalN) modifications. To correlate our structural studies with clinically relevant samples, we characterized colistin-susceptible and -resistant isolates obtained from patients. These results demonstrated that the clinical colistin-resistant isolate had the same pEtN and GalN modifications as those seen in the laboratory-adapted A. baumannii strain MAC204. In summary, this work has shown complete structure characterization including the accurate assignment of acylation, phosphorylation, and glycosylation of lipid A from A. baumannii, which are important for resistance to colistin. C1 [Pelletier, Mark R.; Casella, Leila G.; Ernst, Robert K.] Univ Maryland, Sch Dent, Dept Microbial Pathogenesis, Baltimore, MD 21201 USA. [Jones, Jace W.] Univ Maryland, Sch Pharm, Dept Pharmaceut Sci, Baltimore, MD 21201 USA. [Adams, Mark D.] J Craig Venter Inst, La Jolla, CA USA. [Zurawski, Daniel V.] Walter Reed Army Inst Res, Dept Wound Infect BRD, Silver Spring, MD USA. [Hazlett, Karsten R. O.] Albany Med Coll, Ctr Immunol & Microbial Dis, Albany, NY 12208 USA. [Doi, Yohei] Univ Pittsburgh, Sch Med, Div Infect Dis, Pittsburgh, PA USA. RP Ernst, RK (reprint author), Univ Maryland, Sch Dent, Dept Microbial Pathogenesis, Baltimore, MD 21201 USA. EM rkernst@umaryland.edu OI Zurawski, Daniel/0000-0002-7920-5601 FU NIH [K22AI080584]; Military Infectious Diseases Research Program (MIDRP); Defense Medical Research and Development Program (DMRDP); U.S. Army Research Laboratory; U.S. Army Research Office [W911NF-11-1-0274] FX Y.D. was supported in part by a career development award from the NIH (K22AI080584). D.V.Z is funded via grants from the Military Infectious Diseases Research Program (MIDRP) and the Defense Medical Research and Development Program (DMRDP). This material is based upon work supported by, or in part by, the U.S. Army Research Laboratory and the U.S. Army Research Office under Contract/Grant no. W911NF-11-1-0274 to K.R.O. H and R.K.E. NR 46 TC 34 Z9 37 U1 1 U2 17 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0066-4804 J9 ANTIMICROB AGENTS CH JI Antimicrob. Agents Chemother. PD OCT PY 2013 VL 57 IS 10 BP 4831 EP 4840 DI 10.1128/AAC.00865-13 PG 10 WC Microbiology; Pharmacology & Pharmacy SC Microbiology; Pharmacology & Pharmacy GA 219BU UT WOS:000324480300029 PM 23877686 ER PT J AU Mehta, KK Paskaleva, EE Azizi-Ghannad, S Ley, DJ Page, MA Dordick, JS Kane, RS AF Mehta, Krunal K. Paskaleva, Elena E. Azizi-Ghannad, Saba Ley, Daniel J. Page, Martin A. Dordick, Jonathan S. Kane, Ravi S. TI Characterization of AmiBA2446, a Novel Bacteriolytic Enzyme Active against Bacillus Species SO APPLIED AND ENVIRONMENTAL MICROBIOLOGY LA English DT Article ID BACTERIOPHAGE ENDOLYSINS; CRYSTAL-STRUCTURE; GENOME SEQUENCE; ANTHRACIS; CEREUS; PEPTIDOGLYCAN; LYSINS; HYDROLASES; CELLULOSE; REVEALS AB There continues to be a need for developing efficient and environmentally friendly treatments for Bacillus anthracis, the causative agent of anthrax. One emerging approach for inactivation of vegetative B. anthracis is the use of bacteriophage endolysins or lytic enzymes encoded by bacterial genomes (autolysins) with highly evolved specificity toward bacterium-specific peptidoglycan cell walls. In this work, we performed in silico analysis of the genome of Bacillus anthracis strain Ames, using a consensus binding domain amino acid sequence as a probe, and identified a novel lytic enzyme that we termed AmiBA2446. This enzyme exists as a homodimer, as determined by size exclusion studies. It possesses N-acetylmuramoyl-L-alanine amidase activity, as determined from liquid chromatography-mass spectrometry (LC-MS) analysis of muropeptides released due to the enzymatic digestion of peptidoglycan. Phylogenetic analysis suggested that AmiBA2446 was an autolysin of bacterial origin. We characterized the effects of enzyme concentration and phase of bacterial growth on bactericidal activity and observed close to a 5-log reduction in the viability of cells of Bacillus cereus 4342, a surrogate for B. anthracis. We further tested the bactericidal activity of AmiBA2446 against various Bacillus species and demonstrated significant activity against B. anthracis and B. cereus strains. We also demonstrated activity against B. anthracis spores after pretreatment with germinants. AmiBA2446 enzyme was also stable in solution, retaining its activity after 4 months of storage at room temperature. C1 [Mehta, Krunal K.; Paskaleva, Elena E.; Dordick, Jonathan S.; Kane, Ravi S.] Rensselaer Polytech Inst, Howard P Isermann Dept Chem & Biol Engn, Troy, NY 12181 USA. [Mehta, Krunal K.; Paskaleva, Elena E.; Dordick, Jonathan S.; Kane, Ravi S.] Rensselaer Polytech Inst, Ctr Biotechnol & Interdisciplinary Studies, Troy, NY USA. [Dordick, Jonathan S.] Rensselaer Polytech Inst, Dept Mat Sci & Engn, Troy, NY USA. [Azizi-Ghannad, Saba; Dordick, Jonathan S.] Rensselaer Polytech Inst, Dept Biol, Troy, NY 12180 USA. [Ley, Daniel J.; Page, Martin A.] US Army Corps Engineers, Engineer Res & Dev Ctr, Construct Engn Res Lab, Champaign, IL USA. [Dordick, Jonathan S.] Rensselaer Polytech Inst, Dept Biomed Engn, Troy, NY 12180 USA. RP Kane, RS (reprint author), Rensselaer Polytech Inst, Howard P Isermann Dept Chem & Biol Engn, Troy, NY 12181 USA. EM dordick@rpi.edu; kaner@rpi.edu FU Defense Threat Reduction Agency [W9132T-11-C-00]; U.S. Army Corps of Engineers Engineer Research and Development Center FX We acknowledge financial support from the Defense Threat Reduction Agency (W9132T-11-C-00) via a cooperative research agreement with the U.S. Army Corps of Engineers Engineer Research and Development Center. NR 53 TC 6 Z9 6 U1 2 U2 22 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0099-2240 J9 APPL ENVIRON MICROB JI Appl. Environ. Microbiol. PD OCT PY 2013 VL 79 IS 19 BP 5899 EP 5906 DI 10.1128/AEM.02235-13 PG 8 WC Biotechnology & Applied Microbiology; Microbiology SC Biotechnology & Applied Microbiology; Microbiology GA 214YX UT WOS:000324176900011 PM 23872558 ER PT J AU Rosenberg, H AF Rosenberg, Henry TI Myopathic changes in malignant hyperthermia-susceptible patients SO CANADIAN JOURNAL OF ANESTHESIA-JOURNAL CANADIEN D ANESTHESIE LA English DT Editorial Material ID RYR1 C1 [Rosenberg, Henry] USA, Malignant Hyperthermia Assoc, Sherburne, NY USA. [Rosenberg, Henry] St Barnabas Hosp, Dept Med Educ & Clin Res, Livingston, NJ USA. RP Rosenberg, H (reprint author), St Barnabas Hosp, Dept Med Educ & Clin Res, Livingston, NJ USA. EM henryrosenberg@yahoo.com NR 7 TC 2 Z9 2 U1 0 U2 6 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0832-610X J9 CAN J ANESTH JI Can. J. Anesth. PD OCT PY 2013 VL 60 IS 10 BP 955 EP 959 DI 10.1007/s12630-013-0011-y PG 5 WC Anesthesiology SC Anesthesiology GA 221DC UT WOS:000324636700001 PM 23897489 ER PT J AU Cheppudira, B Fowler, M McGhee, L Greer, A Mares, A Petz, L Devore, D Loyd, DR Clifford, JL AF Cheppudira, Bopaiah Fowler, Marcie McGhee, Laura Greer, Angie Mares, Alberto Petz, Lawrence Devore, David Loyd, Dayna R. Clifford, John L. TI Curcumin: a novel therapeutic for burn pain and wound healing SO EXPERT OPINION ON INVESTIGATIONAL DRUGS LA English DT Review DE curcumin; inflammatory pain; painful neuropathy; wound dressing; wound healing ID DRUG-DELIVERY SYSTEMS; NEUROPATHIC PAIN; MOUSE MODEL; TNF-ALPHA; RAT; INJURY; MANAGEMENT; TISSUE; CELLS; MICE AB Introduction: Managing burn injury-associated pain and wounds is a major unresolved clinical problem. Opioids, nonsteroidal antiinflammatory drugs (NSAIDs), antidepressants and anticonvulsants remain the most common forms of analgesic therapy to treat burn patients. However, prolonged treatment with these drugs leads to dose escalation and serious side effects. Additionally, severe burn wounds cause scarring and are susceptible to infection. Recent encouraging findings demonstrate that curcumin, a major bioactive component found in turmeric, is a natural pharmacotherapeutic for controlling both severe burn pain and for improved wound healing. Areas covered: This article covers current pr-clinical and clinical studies on the analgesic and wound healing effects. Particular emphasis has been placed on studies aimed at developing improved curcumin delivery vehicles that increase its bioavailability. Based on the available evidence, a hypothesis is proposed that the dual beneficial effects of curcumin, analgesia and enhanced wound healing are mediated through common anti-inflammatory mechanisms. Expert opinion: Emerging studies have demonstrated that curcumin is a promising investigational drug to treat both pain and wounds. The adequate control of severe burn pain, particularly over the long courses required for healing, as well improvements in burn wound healing are unmet clinical needs. C1 [Cheppudira, Bopaiah; Fowler, Marcie; Greer, Angie; Mares, Alberto; Petz, Lawrence; Loyd, Dayna R.; Clifford, John L.] US Army Inst Surg Res, Battlefield Pain Management Res Task Area, Ft Sam Houston, TX 78234 USA. [Devore, David] US Army Inst Surg Res, San Antonio Mil Med Ctr, Ft Sam Houston, TX 78234 USA. [McGhee, Laura] Def & Vet Ctr Integrat Pain Management, Rockville, MD 20852 USA. RP Clifford, JL (reprint author), US Army Inst Surg Res, Battlefield Pain Management Res Task Area, 3698 Chambers Pass, Ft Sam Houston, TX 78234 USA. EM john.l.clifford2@us.army.mil OI Loyd, Dayna/0000-0002-5635-185X; Averitt, Dayna/0000-0001-8345-4988 FU United States Army Medical Research and Materiel Command Combat Casualty Care Research; Clinical and Rehabilitative Medicine Research program; National Research Council (NRC) FX This work was supported by the United States Army Medical Research and Materiel Command Combat Casualty Care Research and the Clinical and Rehabilitative Medicine Research programs. B Cheppudira is supported by National Research Council (NRC) Senior Research Associate Fellowship. The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the Department of the Army or the Department of Defense. NR 87 TC 12 Z9 13 U1 5 U2 53 PU INFORMA HEALTHCARE PI LONDON PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND SN 1354-3784 J9 EXPERT OPIN INV DRUG JI Expert Opin. Investig. Drugs PD OCT PY 2013 VL 22 IS 10 BP 1295 EP 1303 DI 10.1517/13543784.2013.825249 PG 9 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA 220JK UT WOS:000324578900007 PM 23902423 ER PT J AU Rambaran, VH Erves, TR Grover, K Balof, S Moody, LV Ramsdale, SE Seymour, LA VanDerveer, D Cropek, DM Weber, RT Holder, AA AF Rambaran, Varma H. Erves, Travis R. Grover, Kristy Balof, Shawna Moody, LaMaryet V. Ramsdale, Stuart E. Seymour, Luke A. VanDerveer, Don Cropek, Donald M. Weber, Ralph T. Holder, Alvin A. TI A Comparison of the Self Assembled Frameworks of Three Cobalt(II) Coordination Compounds Bearing Dipicolinic Acid and Chelidamic Acid Ligands SO JOURNAL OF CHEMICAL CRYSTALLOGRAPHY LA English DT Article DE Cobalt complexes; 2-(H-Pyrazol-3-yl)-pyridine; Dipicolinic acid; Chelidamic acid; pi-pi Stacking; Hydrogen bonding ID PYRIDINE-2,6-DICARBOXYLIC ACID; CRYSTAL-STRUCTURES; CO-II; COMPLEXES; STACKING; NETWORK; ANION; STATE; PROBE AB A comparison of the self assembled lattice structures of unpublished coordination compound, [Co(dipic-OH)(OH2)(3)]center dot 1.5H(2)O (I) (where dipic-OH = 4-hydroxypyridine-2,6-dicarboxylate anion) and two novel cobalt(II)-containing coordination compounds, [Co(dipic)(pyz)(OH2)]center dot 0.25DMSO (II) (where dipic = dipicolinate anion and pyz = 2-(H-pyrazol-3-yl)-pyridine) and [Co(dipic-OH)(pyz)(OH2)]center dot H2O (III), have revealed remarkable distinctions in the hierarchy of their respective structures. The three dimensional (3-D) layered scaffold of compound I and the "zigzag" motifs of compounds II and III were found to have been created via unique hydrogen bonding patterns. Interestingly, compound III displayed a secondary 3-D channel framework, which was made possible by pi-pi stacking interactions. Spectroscopic studies yielded results that were consistent with the predicted behaviors of the various species of substituted ligands. X-ray crystallography revealed that compound I crystallized in the monoclinic space group C2/c with a = 14.734(3) a"<<, b = 6.8664(14) a"<<, c = 22.411(5) a"<<, alpha = 90A degrees, beta = 90.097(7)A degrees, gamma = 90A degrees, V = 2267.4(8) a"<<(3), Z = 8; compound II crystallized in the monoclinic space group P2(1)/n with a = 11.621(3) a"<<, b = 12.391(3) a"<<, c = 12.537(4) a"<<, alpha = 90A degrees, beta = 102.148(11)A degrees, gamma = 90A degrees, V = 1764.8(8) a"<<(3), Z = 4; and compound III crystallized in the orthorhombic space group Pccn with a = 21.899(2) a"<<, b = 10.8845(11) a"<<, c = 15.7093(13) a"<<, alpha = 90A degrees, beta = 90A degrees, gamma = 90A degrees, V = 3744.4(6) a"<<(3), Z = 8. C1 [Rambaran, Varma H.] Univ Trinidad & Tobago, Arima, Trinid & Tobago. [Erves, Travis R.; Grover, Kristy; Balof, Shawna; Moody, LaMaryet V.; Ramsdale, Stuart E.; Seymour, Luke A.; Holder, Alvin A.] Univ So Mississippi, Dept Chem & Biochem, Hattiesburg, MS 39406 USA. [VanDerveer, Don] Clemson Univ, Dept Chem, Clemson, SC 29634 USA. [Cropek, Donald M.] US Army Corps Engineers, Construct Engn Res Lab, Champaign, IL 61822 USA. [Weber, Ralph T.] EPR Div Bruker BioSpin, Billerica, MA 01821 USA. RP Holder, AA (reprint author), Old Dominion Univ, Dept Chem & Biochem, 4541 Hampton Blvd, Norfolk, VA 23529 USA. EM varma.rambaran@utt.edu.tt; aholder@odu.edu RI G, Neela/H-3016-2014; Holder, Alvin/B-6329-2016 OI Holder, Alvin/0000-0001-9618-5297 FU U.S. Army Engineer Research and Development Center, Construction Engineering Research Laboratory; Center Directed Research Program at the U.S. Army Corps of Engineers; Mississippi INBRE; National Institute of General Medical Sciences of the National Institutes of Health [P20 GM103476] FX This research was supported in part by an appointment to the Student Research Participation Program at the U.S. Army Engineer Research and Development Center, Construction Engineering Research Laboratory, administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the U.S. Department of Energy and ERDC-CERL. This work was also supported by the Center Directed Research Program at the U.S. Army Corps of Engineers. This work was also supported by the Mississippi INBRE funded by an IDeA award from the National Institute of General Medical Sciences of the National Institutes of Health under grant number P20 GM103476. NR 33 TC 4 Z9 4 U1 0 U2 6 PU SPRINGER/PLENUM PUBLISHERS PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1074-1542 EI 1572-8854 J9 J CHEM CRYSTALLOGR JI J. Chem. Crystallogr. PD OCT PY 2013 VL 43 IS 10 BP 509 EP 516 DI 10.1007/s10870-013-0437-7 PG 8 WC Crystallography; Spectroscopy SC Crystallography; Spectroscopy GA 221IZ UT WOS:000324652800001 ER PT J AU Brosten, TR AF Brosten, Tyler R. TI Short-time asymptotics of hydrodynamic dispersion in porous media SO JOURNAL OF FLUID MECHANICS LA English DT Article DE low-Reynolds-number flows; mixing and dispersion; porous media ID LATTICE BOLTZMANN METHOD; LONGITUDINAL DISPERSION; RANDOM ARRAYS; HEAT KERNEL; DIFFUSION; FLOWS; SOLUTE; CONTAMINANT; SIMULATION; EXPANSION AB We consider convection-diffusion transport of a passive scalar within porous media having a piecewise-smooth and reflecting pore-grain interface. The corresponding short-time expansion of molecular displacement time-correlation functions is determined for the generalized steady convection field. By interpreting the generalized short-time expansion of dispersion dynamics in the context of low-Reynolds-number flow through macroscopically homogeneous porous media, we demonstrate the connection between hydrodynamic permeability and short-time dynamics. The analytical short-time expansion is compared with numerical simulation data for steady low-Reynolds-number flow through a random close-pack array of mono-disperse spheres. The quadratic short-time expansion term of the dispersion coefficient closely predicts the numerical data for a mean displacement of at least 10% of the sphere diameter for a Peclet number of 54.49. C1 US Army Engn Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Brosten, TR (reprint author), US Army Engn Res & Dev Ctr, Vicksburg, MS 39180 USA. EM tyler.brosten@usace.army.mil NR 48 TC 1 Z9 1 U1 3 U2 26 PU CAMBRIDGE UNIV PRESS PI NEW YORK PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA SN 0022-1120 J9 J FLUID MECH JI J. Fluid Mech. PD OCT PY 2013 VL 732 BP 687 EP 705 DI 10.1017/jfm.2013.429 PG 19 WC Mechanics; Physics, Fluids & Plasmas SC Mechanics; Physics GA 223BS UT WOS:000324779300031 ER PT J AU Chiao, S Dumais, R AF Chiao, Sen Dumais, Robert, Jr. TI A down-valley low-level jet event during T-REX 2006 SO METEOROLOGY AND ATMOSPHERIC PHYSICS LA English DT Article ID BOUNDARY-LAYER EVOLUTION; LOW-ANGLE SLOPE; PART I; DOWNSLOPE FLOWS; MOUNTAIN BASIN; MODEL; SYSTEM; SENSITIVITY; INVERSIONS; TURBULENCE AB A prolonged down-valley flow and low-level jet were observed throughout the Enhanced Observing Period 4 (April 28-29) of the 2006 Terrain-induced Rotor Experiment, held in the Owens Valley of California near the town of Independence. The low-level jet was strongest during the nocturnal hours, and special field observations captured important details of the event lifecycle. High-resolution simulations using the Weather Research and Forecasting numerical weather prediction model were generated, with underlying assumptions being that model resolution, boundary layer physics, and nesting configuration would be dominant controlling factors in reproducing the jet. The large-scale conditions were dry throughout the event, so moist physics were not a significant forcing consideration. For the control simulation, a two-nest (4.5 and 1.5 km grid spacing) configuration with 90 vertical levels was applied. Additionally, the Quasi-Normal Scale Elimination planetary boundary and surface layer option were selected due to its published performance under conditions of stable stratification. Three other sensitivity simulations were run for comparison, differing from the control just in the choice of vertical resolution (60 versus 90 levels with Quasi-Normal Scale Elimination) and planetary boundary/surface layer physics (90 levels/Mellor-Yamada-Jancic; 90 levels/Yonsei State University). Although the gross evolution (location, height, and timing) of the low-level jet is captured by all model runs (with the 1.5 km inner nest providing the more accurate details), there were at times large underestimations of the nocturnal jet speed max in each simulation (approaching 100 % error, or up to almost 10 m s(-1)). Overall, the variations of vertical resolution and planetary boundary/surface physics against the control seemed to (1) yield little overall improvement to statistical or subjective evaluations; (2) do little to improve deficiencies in reproducing the magnitude strength of the nocturnal down-valley low-level jet. Since the cold-start simulations spanned 36 h (including a 12-h spin-up period), it was suspected that the lateral boundary conditions imposed on the outermost 4.5 km nest might negatively impact the interior model solutions in the Owens Valley. To investigate this possibility, an additional simulation was executed by adding two extra nests to the control configuration: an outer 13.5 km and an inner 500 m. This simulation produced a better evolution of the nocturnal low-level jet and especially the speed max. The addition of the larger 13.5 km nest appears more critical to this improvement than that of the extra spatial resolution provided by the inner 500 m nest, which supports the idea that accurate capturing of the large-scale synoptic condition was critical in reproducing important details of this down-valley low-level jet event. The extra 500-m resolution did seem to improve the morning valley cold pool forecast. C1 [Chiao, Sen] San Jose State Univ, Dept Meteorol & Climate Sci, San Jose, CA 95192 USA. [Dumais, Robert, Jr.] US Army Res Lab, White Sand Missile Range, NM USA. RP Chiao, S (reprint author), San Jose State Univ, Dept Meteorol & Climate Sci, San Jose, CA 95192 USA. EM sen.chiao@sjsu.edu OI Chiao, Sen/0000-0001-7117-1577 FU US Army Research Office [W911NF-09-1-0441] FX The critical reviews of three anonymous reviewers were very helpful. The AWS data (DRI, HOBOs, and Leeds) were gathered as part of the Terrain-induced Rotor Experiment (T-REX). We acknowledge the suppliers of datasets employed here. Dr. William Brown at NCAR/EOL provides the ISS2 data and plotting software for Fig. 2. Discussions with Drs., Walter Bach, Semion Sukoriansky and Boris Galperin were appreciated. The research was supported by the Grant W911NF-09-1-0441 from the US Army Research Office. NR 33 TC 2 Z9 2 U1 0 U2 6 PU SPRINGER WIEN PI WIEN PA SACHSENPLATZ 4-6, PO BOX 89, A-1201 WIEN, AUSTRIA SN 0177-7971 J9 METEOROL ATMOS PHYS JI Meteorol. Atmos. Phys. PD OCT PY 2013 VL 122 IS 1-2 BP 75 EP 90 DI 10.1007/s00703-013-0279-z PG 16 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA 224KI UT WOS:000324883600007 ER PT J AU Shaw, AG Vento, TJ Mende, K Kreft, RE Ehrlich, GD Wenke, JC Spirk, T Landrum, ML Zera, W Cheatle, KA Guymon, C Calvano, TP Rini, EA Tully, CC Beckius, ML Murray, CK AF Shaw, Ashley G. Vento, Todd J. Mende, Katrin Kreft, Rachael E. Ehrlich, Garth D. Wenke, Joseph C. Spirk, Tracy Landrum, Michael L. Zera, Wendy Cheatle, Kristelle A. Guymon, Charles Calvano, Tatjana P. Rini, Elizabeth A. Tully, Charla C. Beckius, Miriam L. Murray, Clinton K. TI Detection of methicillin-resistant and methicillin-susceptible Staphylococcus aureus colonization of healthy military personnel by traditional culture, PCR, and mass spectrometry SO SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES LA English DT Article DE MRSA; MSSA; PCR; electrospray-ionization; time-of-flight; mass spectrometry; Ibis T5000; microbiology ID RANDOMIZED CONTROLLED-TRIAL; CHLORHEXIDINE GLUCONATE; INFECTIONS; MRSA; SURVEILLANCE; EPIDEMIOLOGY; POPULATIONS; PREVALENCE; PREVENTION; MUPIROCIN AB Background: Methicillin-resistant (MRSA) and methicillin-susceptible (MSSA) Staphylococcus aureus colonization is associated with increased rates of infection. Rapid and reliable detection methods are needed to identify colonization of nares and extra-nare sites, particularly given recent reports of oropharynx-only colonization. Detection methods for MRSA/MSSA colonization include culture, PCR, and novel methods such as PCR/electrospray ionization time-of-flight mass spectrometry (ESI-TOF-MS). Methods: We evaluated 101 healthy military members for S. aureus colonization in the nares, oropharynx, axilla, and groin, using CHROMagar S. aureus medium and Xpert SA Nasal Complete PCR for MRSA/MSSA detection. The same subjects were screened in the nares, oropharynx, and groin using PCR/ESI-TOF-MS. Results: By culture, 3 subjects were MRSA-colonized (all oropharynx) and 34 subjects were MSSA-colonized (all 4 sites). PCR detected oropharyngeal MRSA in 2 subjects, which correlated with culture findings. By PCR, 47 subjects were MSSA-colonized (all 4 sites); however, 43 axillary samples were invalid, 39 of which were associated with deodorant/anti-perspirant use (93%, p < 0.01). By PCR/ESI-TOF-MS, 4 subjects were MRSA-colonized, 2 in the nares and 2 in the oropharynx; however, neither of these correlated with positive MRSA cultures. Twenty-eight subjects had MSSA by PCR/ESI-TOF-MS, and 41 were found to have possible MRSA (S. aureus with mec A and coagulase-negative Staphylococcus (CoNS)). Conclusion: The overall 3% MRSA colonization rate is consistent with historical reports, but the oropharynx-only colonization supports more recent findings. In addition, the use of deodorant/anti-perspirant invalidated axillary PCR samples, limiting its utility. Defining MRSA positivity by PCR/ESI-TOF-MS is complicated by co-colonization of S. aureus with CoNS, which can also carry mecA. C1 [Shaw, Ashley G.; Vento, Todd J.; Mende, Katrin; Landrum, Michael L.; Zera, Wendy; Cheatle, Kristelle A.; Calvano, Tatjana P.; Rini, Elizabeth A.; Tully, Charla C.; Beckius, Miriam L.; Murray, Clinton K.] San Antonio Mil Med Ctr, Ft Sam Houston, TX 78234 USA. [Vento, Todd J.; Murray, Clinton K.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [Mende, Katrin; Landrum, Michael L.; Zera, Wendy] Uniformed Serv Univ Hlth Sci, Infect Dis Clin Res Program, Bethesda, MD 20814 USA. [Kreft, Rachael E.; Ehrlich, Garth D.; Spirk, Tracy] Allegheny Singer Res Inst, Ctr Genom Sci, Pittsburgh, PA 15212 USA. [Ehrlich, Garth D.] Drexel Univ, Coll Med, Dept Microbiol & Immunol, Pittsburgh, PA USA. [Ehrlich, Garth D.] Drexel Univ, Coll Med, Dept Otolaryngol Head & Neck Surg, Pittsburgh, PA USA. [Wenke, Joseph C.; Guymon, Charles] US Army, Inst Surg Res, Ft Sam Houston, TX USA. RP Shaw, AG (reprint author), San Antonio Mil Med Ctr, Infect Dis Serv MCHE MDI, 3551 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM ashley.shaw@amedd.army.mil FU Armed Forces Health Surveillance Center; Global Emerging Infections Surveillance & Response System FX This work was supported by the Armed Forces Health Surveillance Center including the Global Emerging Infections Surveillance & Response System. NR 30 TC 5 Z9 5 U1 3 U2 13 PU INFORMA HEALTHCARE PI LONDON PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND SN 0036-5548 J9 SCAND J INFECT DIS JI Scand. J. Infect. Dis. PD OCT PY 2013 VL 45 IS 10 BP 752 EP 759 DI 10.3109/00365548.2013.816439 PG 8 WC Infectious Diseases SC Infectious Diseases GA 220JN UT WOS:000324579200004 PM 23957540 ER PT J AU Phillips, J Cardile, AP Patterson, TF Lewis, JS AF Phillips, Jason Cardile, Anthony P. Patterson, Thomas F. Lewis, James S., II TI Daptomycin-induced acute eosinophilic pneumonia: Analysis of the current data and illustrative case reports SO SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES LA English DT Article DE Daptomycin; acute eosinophilic pneumonia ID OF-THE-LITERATURE; PULMONARY SURFACTANT; IMPACT AB Acute eosinophilic pneumonia (AEP) is a rare but important complication of daptomycin therapy. We describe 2 cases of daptomycin-associated AEP, compile available data from another 22 published cases, and propose a revised set of diagnostic criteria. C1 [Phillips, Jason; Patterson, Thomas F.; Lewis, James S., II] Univ Texas Hlth Sci Ctr San Antonio, Dept Med, San Antonio, TX 78229 USA. [Cardile, Anthony P.] Brooke Army Med Ctr, Infect Dis Serv, Ft Sam Houston, TX 78234 USA. [Patterson, Thomas F.] South Texas Vet Hlth Care Syst, Med Serv, San Antonio, TX USA. RP Cardile, AP (reprint author), Brooke Army Med Ctr, Infect Dis Serv MCHE MDI, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM anthony.cardile@us.army.mil NR 18 TC 9 Z9 9 U1 0 U2 7 PU INFORMA HEALTHCARE PI LONDON PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND SN 0036-5548 J9 SCAND J INFECT DIS JI Scand. J. Infect. Dis. PD OCT PY 2013 VL 45 IS 10 BP 804 EP 808 DI 10.3109/00365548.2013.805427 PG 5 WC Infectious Diseases SC Infectious Diseases GA 220JN UT WOS:000324579200013 PM 23826793 ER PT J AU Peach, CM Morrison, JJ Apodaca, AN Egan, G Watson, HG Jansen, JO AF Peach, Christopher M. Morrison, Jonathan J. Apodaca, Amy N. Egan, Gerry Watson, Henry G. Jansen, Jan O. TI Destination healthcare facility of shocked trauma patients in Scotland: Analysis of transfusion and surgical capability of receiving hospitals SO SURGEON-JOURNAL OF THE ROYAL COLLEGES OF SURGEONS OF EDINBURGH AND IRELAND LA English DT Article DE Trauma; Trauma systems; Triage; Shock; Transfusion ID PATIENTS MULTICENTER COHORT; SEVERELY INJURED PATIENTS; SYSTOLIC BLOOD-PRESSURE; INCREASED MORTALITY; TRANEXAMIC ACID; 110 MMHG; HEMORRHAGE; SYSTEMS; CENTERS; RESUSCITATION AB Aims: Haemorrhage is a leading cause of death from trauma. Management requires a combination of haemorrhage control and resuscitation which may incur significant surgical and transfusion utilisation. The aim of this study is to evaluate the resource provision of the destination hospital of Scottish trauma patients exhibiting evidence of pre-hospital shock. Methods: Patients who sustained a traumatic injury between November 2008 and October 2010 were retrospectively identified from the Scottish Ambulance Service electronic patients record system. Patients with a systolic blood pressure less than 110 mmHg or if missing, a heart rate greater than 120 bpm, were considered in shock. The level of the destination healthcare facility was classified in terms of surgical and transfusion capability. Patients with and without shock were compared. Results: There were 135 004 patients identified, 133 651 (99.0%) of whom had sustained blunt trauma, 68 411 (50.7%) were male and the median (IQR) age was 59 (46). There were 6721 (5.0%) patients with shock, with a similar age and gender distribution to non-shocked patients. Only 1332 (19.8%) of shocked patients were taken to facilities with full surgical capability, 5137 (76.4%) to hospitals with limited (general and orthopaedic-surgery only) and 252 (3.7%) to hospitals with no surgical services. In terms of transfusion capability, 5556 (82.7%) shocked patients were admitted to facilities with full capability and 1165 (17.3%) to a hospital with minimal or no capability. Conclusions: The majority of Scottish trauma patients are transported to a hospital with full transfusion capability, although the majority lack surgical sub-specialty representation. (C) 2013 Royal College of Surgeons of Edinburgh (Scottish charity number SC005317) and Royal College of Surgeons in Ireland. Published by Elsevier Ltd. All rights reserved. C1 [Peach, Christopher M.] Monklands Hosp, Dept Surg, Airdrie, Scotland. [Morrison, Jonathan J.] Royal Ctr Def Med, Acad Depal Linent Mil Surg & Trauma, Birmingham, W Midlands, England. [Morrison, Jonathan J.; Apodaca, Amy N.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Egan, Gerry] Scottish Ambulance Serv, Edinburgh, Midlothian, Scotland. [Watson, Henry G.] Aberdeen Royal Infirm, Dept Haematol, Aberdeen, Scotland. [Jansen, Jan O.] Aberdeen Royal Infirm, Dept Surg, Aberdeen, Scotland. [Jansen, Jan O.] Aberdeen Royal Infirm, Dept Intens Care Med, Aberdeen, Scotland. RP Morrison, JJ (reprint author), Royal Ctr Def Med, Acad Depal Linent Mil Surg & Trauma, Birmingham, W Midlands, England. EM jjmorrison@outlook.com OI Morrison, Jonathan/0000-0001-7462-8456 NR 26 TC 2 Z9 2 U1 0 U2 0 PU ROYAL COLLEGE SURGEONS EDINBURGH PI EDINBURGH PA NICOLSON ST, EDINBURGH EH8 9DW, SCOTLAND SN 1479-666X J9 SURG-J R COLL SURG E JI Surg. J. R. Coll. Surg. Edinb. Irel. PD OCT PY 2013 VL 11 IS 5 BP 272 EP 277 DI 10.1016/j.surge.2013.01.003 PG 6 WC Surgery SC Surgery GA 225PP UT WOS:000324975100008 PM 23402864 ER PT J AU Ko, KS Mizanur, RM Jackson, JM Liu, L Pohl, NLB AF Ko, Kwang-Seuk Mizanur, Rahman M. Jackson, Joy M. Liu, Lin Pohl, Nicola L. B. TI A mass-differentiated library strategy for identification of sugar nucleotidyltransferase activities from cell lysates SO ANALYTICAL BIOCHEMISTRY LA English DT Article DE Sugar nucleotidyltransferases; Mass spectrometry; Carbohydrate libraries; Enzyme assay ID ACTIVITY-BASED PROBES; CATALYTIC MECHANISM; ESCHERICHIA-COLI; KINETIC-ANALYSIS; SPECTROMETRY; ENZYME; PROTEOMICS; DISCOVERY; ASSAY; PYROPHOSPHORYLASE AB Sugar nucleotidyltransferases, or nucleotide sugar pyrophosphorylases, are ubiquitous enzymes whose activities have been correlated to disease states and pathogen virulence. Here we report a rapid "one-pot" method to identify a range of sugar nucleotidyltransferase activities of purified proteins or in cell lysates using a mass-differentiated carbohydrate library designed for mass spectrometry-based analysis. (c) 2013 Elsevier Inc. All rights reserved. C1 [Ko, Kwang-Seuk; Mizanur, Rahman M.; Jackson, Joy M.; Liu, Lin; Pohl, Nicola L. B.] Iowa State Univ, Dept Chem, Dept Chem & Biol Engn, Ames, IA 50011 USA. [Ko, Kwang-Seuk; Mizanur, Rahman M.; Jackson, Joy M.; Liu, Lin; Pohl, Nicola L. B.] Iowa State Univ, Inst Plant Sci, Ames, IA 50011 USA. [Mizanur, Rahman M.] US Army, Dept Biochem & Cell Biol, Div Integrated Toxicol, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. [Jackson, Joy M.; Pohl, Nicola L. B.] Indiana Univ, Dept Chem, Bloomington, IN 47405 USA. RP Pohl, NLB (reprint author), Indiana Univ, Dept Chem, Bloomington, IN 47405 USA. EM npohl@indiana.edu OI Liu, Lin/0000-0002-0310-5946 FU US National Science Foundation [0349139, CHE-0911123/1261046]; Herman Frasch Foundation; Shimadzu University; Joan and Marvin Carmack Fund; National Science Foundation [DGE-1007911] FX This work was supported in part by the US National Science Foundation under CAREER Grant 0349139 and CHE-0911123/1261046, the Herman Frasch Foundation (administered by the American Chemical Society), and a Shimadzu University Research Grant. N.L.B.P. acknowledges the Joan and Marvin Carmack Fund, and J.M.J. acknowledges a fellowship from the National Science Foundation GK-12 Grant (DGE-1007911) to Iowa State University (principal investigator: Basil Nikolau; co-principal investigator: Adah Leshem). NR 35 TC 0 Z9 0 U1 1 U2 9 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0003-2697 J9 ANAL BIOCHEM JI Anal. Biochem. PD OCT 1 PY 2013 VL 441 IS 1 BP 8 EP 12 DI 10.1016/j.ab.2013.06.004 PG 5 WC Biochemical Research Methods; Biochemistry & Molecular Biology; Chemistry, Analytical SC Biochemistry & Molecular Biology; Chemistry GA 209ZW UT WOS:000323800100002 PM 23811154 ER PT J AU Zamora, DO Natesan, S Becerra, S Wrice, N Chung, E Suggs, LJ Christy, RJ AF Zamora, David O. Natesan, Shanmugasundaram Becerra, Sandra Wrice, Nicole Chung, Eunna Suggs, Laura J. Christy, Robert J. TI Enhanced wound vascularization using a dsASCs seeded FPEG scaffold SO ANGIOGENESIS LA English DT Article DE Angiogenesis; ASCs; Wound healing; Fibrin; Collagen; PEG ID ADIPOSE STROMAL CELLS; IMPROVE POSTNATAL NEOVASCULARIZATION; OPERATION ENDURING FREEDOM; ENDOTHELIAL GROWTH-FACTOR; STEM-CELLS; IN-VITRO; IRAQI FREEDOM; TISSUE; SKIN; ANGIOGENESIS AB The bioengineering of autologous vascular networks is of great importance in wound healing. Adipose-derived stem cells (ASCs) are of interest due to their ability to differentiate toward various cell types, including vascular. We hypothesized that adult human ASCs embedded in a three-dimensional PEG-fibrin (FPEG) gel have the ability to modulate vascularization of a healing wound. Initial in vitro characterization of ASCs isolated from discarded burn skin samples (dsASCs) and embedded in FPEG gels indicated they could express such pericyte/smooth muscle cell markers as alpha-smooth muscle actin, platelet-derived growth factor receptor-beta, NG2 proteoglycan, and angiopoietin-1, suggesting that these cells could potentially be involved in a supportive cell role (i.e., pericyte/mural cell) for blood vessels. Using a rat skin excision model, wounds treated with dsASCs-FPEG gels showed earlier collagen deposition and wound remodeling compared to vehicle FPEG treated wounds. Furthermore, the dsASCs-seeded gels increased the number of vessels in the wound per square millimeter by day 16 (similar to 66.7 vs. similar to 36.9/mm(2)) in these same studies. dsASCs may support this increase in vascularization through their trophic contribution of vascular endothelial growth factor, as determined by in vitro analysis of mRNA and the protein levels. Immunohistochemistry showed that dsASCs were localized to the surrounding regions of large blood-perfused vessels. Human dsASCs may play a supportive role in the formation of vascular structures in the healing wound through direct mechanisms as well as indirect trophic effects. The merging of autologous grafts or bioengineered composites with the host's vasculature is critical, and the use of autologous dsASCs in these procedures may prove to be therapeutic. C1 [Zamora, David O.; Natesan, Shanmugasundaram; Becerra, Sandra; Wrice, Nicole; Christy, Robert J.] US Army Inst Surg Res, Regenerat Med Res Program, Ft Sam Houston, TX 78234 USA. [Chung, Eunna; Suggs, Laura J.] Univ Texas Austin, Dept Biomed Engn, Austin, TX 78712 USA. RP Christy, RJ (reprint author), US Army Inst Surg Res, Regenerat Med Res Program, 3698 Chambers Pass,BHT 1 Bldg 3611, Ft Sam Houston, TX 78234 USA. EM robert.j.christy12.civ@mail.mil OI Natesan, Shanmugasundaram/0000-0003-4213-3111 FU Pittsburgh Tissue Engineering Initiative (PTEI); TATRC Foundation; Deployment Related Medical Research Program FX Dr. Natesan is supported by a Postdoctoral Fellowship Grant from the Pittsburgh Tissue Engineering Initiative (PTEI). Funding for this work was provided by the TATRC Foundation and the Deployment Related Medical Research Program. NR 40 TC 19 Z9 21 U1 1 U2 23 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0969-6970 J9 ANGIOGENESIS JI Angiogenesis PD OCT PY 2013 VL 16 IS 4 BP 745 EP 757 DI 10.1007/s10456-013-9352-y PG 13 WC Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 216ZV UT WOS:000324326900002 PM 23709171 ER PT J AU Belkin, A Ender, MG Frank, N Furia, SR Lucas, G Packard, G Samuels, SM Schultz, T Segal, DR AF Belkin, Aaron Ender, Morten G. Frank, Nathaniel Furia, Stacie R. Lucas, George Packard, Gary Samuels, Steven M. Schultz, Tammy Segal, David R. TI Readiness and DADT Repeal: Has the New Policy of Open Service Undermined the Military? SO ARMED FORCES & SOCIETY LA English DT Article DE gays in the military; "don't ask; don't tell"; DADT AB Prior to the repeal of don't ask, don't tell (DADT) on September 20, 2011, many observers predicted that allowing lesbian, gay and bisexual troops to serve openly would harm the military, and a group of more than 1,000 retired general and flag officers predicted that repeal could break the All-Volunteer Force. This study is the first scholarly effort to assess the accuracy of such predictions about the impact of DADT repeal on military readiness. We conducted our research during the half-year period starting six months after repeal and concluding at the one year mark, and we pursued ten separate research strategies including in-depth interviews, survey analysis, on-site field observations, pretest/posttest quasi experimentation, secondary source analysis, and a comprehensive review of media articles. Our goal was to maximize the likelihood of identifying evidence of damage caused by repeal, and we made vigorous efforts to collect data from repeal opponents including anti-repeal generals and admirals, activists, academic experts, service members and watchdog organizations. Our conclusion, based on all of the evidence available to us, is that DADT repeal has had no overall negative impact on military readiness or its component dimensions, including cohesion, recruitment, retention, assaults, harassment, or morale. If anything, DADT repeal appears to have enhanced the military's ability to pursue its mission. C1 [Belkin, Aaron] SFSU, San Francisco, CA 94110 USA. [Ender, Morten G.] US Mil Acad, Dept Behav Sci & Leadership, West Point, NY 10996 USA. [Frank, Nathaniel] Columbia Univ, New York, NY USA. [Furia, Stacie R.] Univ Calif Los Angeles, Los Angeles, CA USA. [Lucas, George] USNA, Eth Vice Admiral James B Stockdale Ctr Eth Leader, Annapolis, MD USA. [Packard, Gary; Samuels, Steven M.] USAFA, Dept Behav Sci & Leadership, Colorado Springs, CO USA. [Schultz, Tammy] US Marine Corps War Coll, Washington, DC USA. [Segal, David R.] Univ Maryland, Ctr Res Mil Org, College Pk, MD 20742 USA. [Segal, David R.] Univ Maryland, College Pk, MD 20742 USA. RP Belkin, A (reprint author), SFSU, 550 S Van Ness 407, San Francisco, CA 94110 USA. EM belkin@palmcenter.org RI Dopko, Rae/J-7437-2015 NR 33 TC 7 Z9 7 U1 3 U2 7 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0095-327X J9 ARMED FORCES SOC JI Armed Forces Soc. PD OCT PY 2013 VL 39 IS 4 BP 587 EP 601 DI 10.1177/0095327X12466248 PG 15 WC Political Science; Sociology SC Government & Law; Sociology GA 211UZ UT WOS:000323938100001 ER PT J AU West, BJ Turalska, M AF West, B. J. Turalska, M. TI Network of echoes SO CHAOS SOLITONS & FRACTALS LA English DT Article ID FUNCTIONAL CONNECTIVITY; NEURONAL AVALANCHES; REPRESENTATION; TRANSITION; DYNAMICS; MODEL AB The decision making model (DMM) previously developed [3,35] has been shown to generate phase transitions, to be topologically complex as manifest by inverse power-law (IPL) degree distributions, and to produce temporal complexity through IPL distributions in the switching times between the two critical states of consensus. These properties are entailed by the fundamental assumption that the network elements in the DMM imperfectly imitate one another, which is postulated herein as the echo response hypothesis; an echo being an imperfect copy of an original signal. Some implications of this hypothesis for the human sciences are explored. (C) 2013 Elsevier Ltd. All rights reserved. C1 [West, B. J.] US Army Res Off, Informat Sci Directorate, Res Triangle Pk, NC 27709 USA. [Turalska, M.] Duke Univ, Dept Phys, Durham, NC 27701 USA. RP Turalska, M (reprint author), Duke Univ, Dept Phys, Durham, NC 27701 USA. EM mat51@phy.duke.edu NR 42 TC 4 Z9 4 U1 0 U2 2 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0960-0779 J9 CHAOS SOLITON FRACT JI Chaos Solitons Fractals PD OCT PY 2013 VL 55 SI SI BP 109 EP 119 DI 10.1016/j.chaos.2013.06.005 PG 11 WC Mathematics, Interdisciplinary Applications; Physics, Multidisciplinary; Physics, Mathematical SC Mathematics; Physics GA 218ST UT WOS:000324453500011 ER PT J AU Bujak, KR Radu, I Catrambone, R MacIntyre, B Zheng, R Golubski, G AF Bujak, Keith R. Radu, Iulian Catrambone, Richard MacIntyre, Blair Zheng, Ruby Golubski, Gary TI A psychological perspective on augmented reality in the mathematics classroom SO COMPUTERS & EDUCATION LA English DT Article DE Augmented reality; Cognition; Human-centered design; Applications in subject areas; Interactive learning environments ID MANIPULATIVES; ENVIRONMENT; EDUCATION AB Physical objects and virtual information are used as teaching aids in classrooms everywhere, and until recently, merging these two worlds has been difficult at best. Augmented reality offers the combination of physical and virtual, drawing on the strengths of each. We consider this technology in the realm of the mathematics classroom, and offer theoretical underpinnings for understanding the benefits and limitations of AR learning experiences. The paper presents a framework for understanding AR learning from three perspectives: physical, cognitive, and contextual. On the physical dimension, we argue that physical manipulation affords natural interactions, thus encouraging the creation of embodied representations for educational concepts. On the cognitive dimension, we discuss how spatiotemporal alignment of information through AR experiences can aid student's symbolic understanding by scaffolding the progression of learning, resulting in improved understanding of abstract concepts. Finally, on the contextual dimension, we argue that AR creates possibilities for collaborative learning around virtual content and in non-traditional environments, ultimately facilitating personally meaningful experiences. In the process of discussing these dimensions, we discuss examples from existing AR applications and provide guidelines for future AR learning experiences, while considering the pragmatic and technological concerns facing the widespread implementation of augmented reality inside and outside the classroom. (C) 2013 Elsevier Ltd. All rights reserved. C1 [Bujak, Keith R.; Catrambone, Richard] Georgia Inst Technol, Sch Psychol, Atlanta, GA 30332 USA. [Radu, Iulian; MacIntyre, Blair; Zheng, Ruby] Georgia Inst Technol, Coll Comp, Atlanta, GA 30332 USA. [Golubski, Gary] US Army, Greenwood, IN 46142 USA. RP Bujak, KR (reprint author), Georgia Inst Technol, Sch Psychol, 654 Cherry St, Atlanta, GA 30332 USA. EM bujak@gatech.edu; iulian@cc.gatech.edu; rc7@prism.gatech.edu; blair@cc.gatech.edu; zhengsan@gmail.com; golubskig@gmail.com NR 45 TC 34 Z9 34 U1 10 U2 97 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0360-1315 J9 COMPUT EDUC JI Comput. Educ. PD OCT PY 2013 VL 68 BP 536 EP 544 DI 10.1016/j.compedu.2013.02.017 PG 9 WC Computer Science, Interdisciplinary Applications; Education & Educational Research SC Computer Science; Education & Educational Research GA 213SP UT WOS:000324080800049 ER PT J AU Gardner, PD Eshbaugh, JP Harpest, SD Richardson, AW Hofacre, KC AF Gardner, Paul D. Eshbaugh, Jonathan P. Harpest, Shannon D. Richardson, Aaron W. Hofacre, Kent C. TI Viable Viral Efficiency of N95 and P100 Respirator Filters at Constant and Cyclic Flow SO JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL HYGIENE LA English DT Article DE particulate respirator; filtration efficiency; viral aerosol; bioaerosol; penetration ID FACEPIECE RESPIRATORS; COLLECTION EFFICIENCIES; PERFORMANCE EVALUATION; SURGICAL MASKS; AEROSOLS; PARTICLES; VIRUS; FILTRATION; NANOPARTICLES; BIOAEROSOLS AB The growing threat of an influenza pandemic presents a unique challenge to healthcare workers, emergency responders, and the civilian population. The Occupational Safety and Health Administration (OSHA) recommends National Institute for Occupational Safety and Health (NIOSH)-approved respirators to provide protection against infectious airborne viruses in various workplace settings. The filtration efficiency of selected NIOSH-approved particulate N95 and P100 filtering facepiece respirators (FFRs) and filter cartridges was investigated against the viable MS2 virus, a non-pathogenic bacteriophage, aerosolized from a liquid suspension. Tests were performed under two cyclic flow conditions (minute volumes of 85 and 135 L/min) and two constant flow rates (85 and 270 L/min). The mean penetrations of viable MS2 through the N95 and P100 FFRs/cartridges were typically less than 2 and 0.03%, respectively, under all flow conditions. All N95 and P100 FFR and cartridge models assessed in this study, therefore, met or exceeded their respective efficiency ratings of 95 and 99.97% against the viable MS2 test aerosol, even under the very high flow conditions. These NIOSH-approved FFRs and particulate respirators equipped with these cartridges can be anticipated to achieve expected levels of protection (consistent with their assigned protection factor) against airborne viral agents, provided that they are properly selected, fitted, worn, and maintained. C1 [Gardner, Paul D.] US Army Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. [Eshbaugh, Jonathan P.; Harpest, Shannon D.; Richardson, Aaron W.; Hofacre, Kent C.] Battelle Mem Inst, Columbus, OH 43201 USA. RP Gardner, PD (reprint author), US Army Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. EM paul.d.gardner12.civ@mail.mil NR 32 TC 5 Z9 5 U1 3 U2 15 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA SN 1545-9624 J9 J OCCUP ENVIRON HYG JI J. Occup. Environ. Hyg. PD OCT 1 PY 2013 VL 10 IS 10 BP 564 EP 572 DI 10.1080/15459624.2013.818228 PG 9 WC Environmental Sciences; Public, Environmental & Occupational Health SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health GA 213VC UT WOS:000324087500008 PM 24011377 ER PT J AU Wu, XW Rathbone, CR AF Wu, Xiaowu Rathbone, Christopher R. TI Satellite cell functional alterations following cutaneous burn in rats include an increase in their osteogenic potential SO JOURNAL OF SURGICAL RESEARCH LA English DT Article DE Skeletal muscle; Muscle precursor cell; Thermal injury; Atrophy; Heterotopic ossification ID SKELETAL-MUSCLE; STEM-CELLS; DIFFERENTIATION; CATABOLISM; APOPTOSIS; ATROPHY; INJURY; FIBERS AB Background: Significant consequences of severe burn include skeletal muscle atrophy and heterotopic ossification (HO). The cellular mechanisms underlying either of these conditions are not known. Whether the functionality of satellite cells stem cells resident in skeletal muscle is affected by changes in circulatory factors following burn was determined to better understand their role in atrophy and HO. Materials and methods: Serum (20%) from sham-treated animals or burned animals (40% total body surface area full-thickness burn) was used to culture satellite cells isolated from either sham or burn animals. Satellite cells were separated based on fiber type (i.e., fast-twitch or slow-twitch in some cases). To gain greater insight into the potential role for satellite cells in controlling muscle mass following burn, the effect of serum taken from burn animals on satellite cell proliferation, migration, and myogenic differentiation was evaluated. Osteogenic differentiation was assessed to evaluate the potential of satellite cells to contribute to HO. Results: Burn serum (BS) increased the proliferative capacity of cells from fast-twitch muscle, and the migratory capacity of satellite cells taken from both fast-and slow-twitch muscles. BS increased both the myogenic and osteogenic differentiation of satellite cells taken from both sham and burn animals. Conclusions: The unexpected increase in myogenic functionality of satellite cells with BS is difficult to rectify, given the degree of atrophy that occurs. However, the increased osteogenic capacity of satellite cells with BS suggests they may play a role in burn-induced HO. (C) 2013 Elsevier Inc. All rights reserved. C1 [Wu, Xiaowu; Rathbone, Christopher R.] US Army Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Wu, XW (reprint author), US Army Inst Surg Res, 3698 Chambers Pass, Ft Sam Houston, TX 78234 USA. EM xiaowu.wu.ctr@mail.mil FU US Army Medical Research and Materiel Command FX The authors thank Ms. Melissa Sanchez for expert technical assistance. Research was supported by US Army Medical Research and Materiel Command. The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or reflecting the views of the US Department of Defense or the US Government. The authors are employees of the US Government. This work was prepared as part of his official duties and, as such, there is no copyright to be transferred. NR 28 TC 2 Z9 2 U1 0 U2 6 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0022-4804 J9 J SURG RES JI J. Surg. Res. PD OCT PY 2013 VL 184 IS 2 BP E9 EP E16 DI 10.1016/j.jss.2013.03.046 PG 8 WC Surgery SC Surgery GA 215XE UT WOS:000324243500002 PM 23582758 ER PT J AU Harvey, P Siu, CO Cucchiaro, J Pikalov, A Loebel, A AF Harvey, P. Siu, C. O. Cucchiaro, J. Pikalov, A. Loebel, A. TI Impact of improved insight in schizophrenia: a double-blind lurasidone and quetiapine XR study SO EUROPEAN NEUROPSYCHOPHARMACOLOGY LA English DT Meeting Abstract C1 [Harvey, P.] Univ Miami, Dept Psychiat & Behav Sci, Miami, FL USA. [Siu, C. O.] Data Power Inc, Quantitat Methodol, Flemington, NJ USA. [Cucchiaro, J.; Pikalov, A.; Loebel, A.] Sunovion Pharmaceut Inc, Clin Dev & Med Affairs, Ft Lee, VA USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0924-977X EI 1873-7862 J9 EUR NEUROPSYCHOPHARM JI Eur. Neuropsychopharmacol. PD OCT PY 2013 VL 23 SU 2 MA P.1.j.007 BP S285 EP S285 PG 1 WC Clinical Neurology; Neurosciences; Pharmacology & Pharmacy; Psychiatry SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry GA V40HR UT WOS:000209470200331 ER PT J AU Grujicic, M Ramaswami, S Snipes, JS Yen, CF Cheeseman, BA Montgomery, JS AF Grujicic, M. Ramaswami, S. Snipes, J. S. Yen, C. -F. Cheeseman, B. A. Montgomery, J. S. TI Multiphysics Modeling and Simulations of Mil A46100 Armor-Grade Martensitic Steel Gas Metal Arc Welding Process SO JOURNAL OF MATERIALS ENGINEERING AND PERFORMANCE LA English DT Article DE Gas Metal Arc Welding (GMAW); MIL A46100; multiphysics process modeling ID MICROSTRUCTURE EVOLUTION; PART II; KINETICS; REAUSTENITIZATION; THERMODYNAMICS; TRANSFORMATION; FABRICATION; PREDICTION; DESIGN; AA5083 AB A multiphysics computational model has been developed for the conventional Gas Metal Arc Welding (GMAW) joining process and used to analyze butt-welding of MIL A46100, a prototypical high-hardness armor martensitic steel. The model consists of five distinct modules, each covering a specific aspect of the GMAW process, i.e., (a) dynamics of welding-gun behavior; (b) heat transfer from the electric arc and mass transfer from the electrode to the weld; (c) development of thermal and mechanical fields during the GMAW process; (d) the associated evolution and spatial distribution of the material microstructure throughout the weld region; and (e) the final spatial distribution of the as-welded material properties. To make the newly developed GMAW process model applicable to MIL A46100, the basic physical-metallurgy concepts and principles for this material have to be investigated and properly accounted for/modeled. The newly developed GMAW process model enables establishment of the relationship between the GMAW process parameters (e.g., open circuit voltage, welding current, electrode diameter, electrode-tip/weld distance, filler-metal feed speed, and gun travel speed), workpiece material chemistry, and the spatial distribution of as-welded material microstructure and properties. The predictions of the present GMAW model pertaining to the spatial distribution of the material microstructure and properties within the MIL A46100 weld region are found to be consistent with general expectations and prior observations. C1 [Grujicic, M.; Ramaswami, S.; Snipes, J. S.] Clemson Univ, Dept Mech Engn, Clemson, SC 29634 USA. [Yen, C. -F.; Cheeseman, B. A.; Montgomery, J. S.] Army Res Lab, Survivabil Mat Branch, Aberdeen, MD 21005 USA. RP Grujicic, M (reprint author), Clemson Univ, Dept Mech Engn, 241 Engn Innovat Bldg, Clemson, SC 29634 USA. EM gmica@clemson.edu FU Army Research Office [W911NF-11-1-0207, W911NF-09-1-0513]; U.S. Army/Clemson University [W911NF-04-2-0024, W911NF-06-2-0042] FX The material presented in this article is based on the work supported by two Army Research Office sponsored grants (W911NF-11-1-0207 and W911NF-09-1-0513) and two U.S. Army/Clemson University Cooperative Agreements (W911NF-04-2-0024 and W911NF-06-2-0042). The authors are indebted to Dr. Larry C. Russell, Jr. of ARO for his continuing support and interest in this study. NR 58 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1059-9495 EI 1544-1024 J9 J MATER ENG PERFORM JI J. Mater. Eng. Perform. PD OCT PY 2013 VL 22 IS 10 BP 2950 EP 2969 DI 10.1007/s11665-013-0583-2 PG 20 WC Materials Science, Multidisciplinary SC Materials Science GA 245HW UT WOS:000326455600017 ER PT J AU Phadikar, JK Bogetti, TA Karlsson, AM AF Phadikar, J. K. Bogetti, T. A. Karlsson, A. M. TI On the uniqueness and sensitivity of indentation testing of isotropic materials SO INTERNATIONAL JOURNAL OF SOLIDS AND STRUCTURES LA English DT Article DE Indentation; Conical; Uniqueness; Sensitivity; Condition number ID MEASURING ELASTOPLASTIC PROPERTIES; SENSING INSTRUMENTED INDENTATION; DUAL SHARP INDENTERS; CONICAL INDENTATION; PLASTIC PROPERTIES; SPHERICAL INDENTATION; RESIDUAL-STRESS; METAL MATERIALS; NANOINDENTATION; EQUATIONS AB Instrumented indentation is a popular technique to extract the material properties of small scale structures. The uniqueness and sensitivity to experimental errors determine the practical usefulness of such experiments. Here, a method to identify test techniques that minimizes sensitivity to experimental erros is in indentation experiments developed. The methods are based on considering "shape functions," which are sets of functions that describe the force-displacement relationship obtained during the indentation test. The concept of condition number is used to investigate the relative reliability of various possible dual indentation techniques. Interestingly, it was found that many dual indentation techniques can be as unreliable as single indentation techniques. Sensitivity analyses were employed for further understanding of the uniqueness and sensitivity to experimental errors of indentation techniques. The advantage of the Monte Carlo approach over other procedures is established. Practical guidelines regarding the selection of shape functions of force-displacement relationship and geometric parameters, while carrying out indentation analysis are provided. The results suggest that indentation experiments need to be very accurate to extract reliable material properties. (C) 2013 Elsevier Ltd. All rights reserved. C1 [Phadikar, J. K.; Karlsson, A. M.] Univ Delaware, Dept Mech Engn, Newark, DE 19716 USA. [Bogetti, T. A.] US Army Res Lab, Aberdeen Proving Ground, MD USA. [Karlsson, A. M.] Cleveland State Univ, Fenn Coll Engn, Cleveland, OH 44115 USA. RP Karlsson, AM (reprint author), Cleveland State Univ, Fenn Coll Engn, Cleveland, OH 44115 USA. EM a.karlsson@csuohio.edu NR 37 TC 8 Z9 8 U1 0 U2 19 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0020-7683 EI 1879-2146 J9 INT J SOLIDS STRUCT JI Int. J. Solids Struct. PD OCT PY 2013 VL 50 IS 20-21 BP 3242 EP 3253 DI 10.1016/j.ijsolstr.2013.05.028 PG 12 WC Mechanics SC Mechanics GA 199SI UT WOS:000323015400017 ER PT J AU Demirbilek, Z AF Demirbilek, Zeki TI Sea level rise and impacts on engineering practice Preface SO OCEAN ENGINEERING LA English DT Editorial Material C1 US Army, Engineer R&D Ctr, Coastal & Hydraul Lab, Vicksburg, MS 39180 USA. RP Demirbilek, Z (reprint author), US Army, Engineer R&D Ctr, Coastal & Hydraul Lab, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM zeki.demirbilek@usace.army.mil NR 0 TC 1 Z9 1 U1 1 U2 17 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0029-8018 J9 OCEAN ENG JI Ocean Eng. PD OCT 1 PY 2013 VL 71 BP 1 EP 2 DI 10.1016/j.oceaneng.2013.07.002 PG 2 WC Engineering, Marine; Engineering, Civil; Engineering, Ocean; Oceanography SC Engineering; Oceanography GA 208PH UT WOS:000323691100001 ER PT J AU Zhou, XY Zheng, JH Doong, DJ Demirbilek, Z AF Zhou, Xiaoyan Zheng, Jinhai Doong, Dong-Jiing Demirbilek, Zeki TI Sea level rise along the East Asia and Chinese coasts and its role on the morphodynamic response of the Yangtze River Estuary SO OCEAN ENGINEERING LA English DT Article DE Sea level rise; Hydrodynamic response; Morphodynamic; Yangtze Estuary ID DELTA; IMPACTS; AREAS AB Coastal phenomena at river estuary areas will be affected by global climate change conditions. This paper reports on analysis of the sea level rise (SLR) from the last 50 years of tide stations data along the East Asia and Chinese coasts and morphodynamic changes in the Yangtze River Estuary determined for four SLR rates. Long-term tide records of 58 stations from the Permanent Service for Mean Sea Level (PSMSL) database were analyzed to develop projected estimates of the SLR trends. The calculated average rate of SLR is 2.67 mm/yr along the East Asia coasts, and 2.89 mm/yr along the Chinese coasts, with a 5.44 mm/yr estimate at the Yangtze Estuary, which is nearly three times the global average. Including the joint effects of the SLR and coastal land subsidence, the relative SLR will range from 1.5 m to 2.7 m at the Yangtze Estuary by the end of this century. Under the conditions of dry season water discharge, numerical simulation results show that the flood and ebb velocities would decrease for the SLR greater than 0.18 m. The areas of influence will increase proportional to the scale of SLR, significantly changing deposition conditions in this river estuary. Simulation results indicate that more dramatic morphological changes occur in the estuary during the dry conditions as compared to wet conditions. During the wet seasons, significant topography changes occur only for the SLR greater than 0.59 m, with an associated increase in the current velocities outside the river mouth. This may induce severe beach erosion problems, especially along the northern coasts of the Yangtze Estuary. (C) 2013 Elsevier Ltd. All rights reserved. C1 [Zhou, Xiaoyan; Zheng, Jinhai] Hohai Univ, State Key Lab Hydrol Water Resources & Hydraul En, Nanjing 210098, Jiangsu, Peoples R China. [Doong, Dong-Jiing] Natl Taiwan Ocean Univ, Dept Marine Environm Informat, Taipei, Taiwan. [Demirbilek, Zeki] US Army, Engineer Res & Dev Ctr, Coastal & Hydraul Lab, Vicksburg, MS 39180 USA. RP Zheng, JH (reprint author), Hohai Univ, State Key Lab Hydrol Water Resources & Hydraul En, Nanjing 210098, Jiangsu, Peoples R China. EM jhzheng@hhu.edu.cn FU National Key Basic Research Project 973 in China [2010CB429002]; Basic Research Funds for the Chinese Central Universities [2012806514]; China Scholarship Council (CSC); Technical University of Darmstadt, German Academic Exchange Service (DAAD); Federal Ministry of Education and Research (BMBF) in Germany FX This research is supported by the National Key Basic Research Project 973 in China (Grant No. 2010CB429002) and the Basic Research Funds for the Chinese Central Universities (2012806514). Part of the results of this paper was carried out during the first author's study in Germany by the support of China Scholarship Council (CSC), and the Technical University of Darmstadt, German Academic Exchange Service (DAAD), and the Federal Ministry of Education and Research (BMBF) in Germany. The first author would like to express her great gratitude. The last author acknowledges the support of the Coastal Inlets Research Program, ERDC, U.S. Army Corps of Engineers, Vicksburg, during this research. Permission was granted by the Chief, U.S. Army Corps of Engineers to publish this information. Much appreciation is expressed to the unknown reviewers for their valuable comments and suggestions. NR 33 TC 11 Z9 16 U1 5 U2 54 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0029-8018 J9 OCEAN ENG JI Ocean Eng. PD OCT 1 PY 2013 VL 71 BP 40 EP 50 DI 10.1016/j.oceaneng.2013.03.014 PG 11 WC Engineering, Marine; Engineering, Civil; Engineering, Ocean; Oceanography SC Engineering; Oceanography GA 208PH UT WOS:000323691100005 ER PT J AU Rajabalinejad, M Demirbilek, Z AF Rajabalinejad, M. Demirbilek, Z. TI A Bayesian probabilistic approach for impacts of sea level rise on coastal engineering design practice SO OCEAN ENGINEERING LA English DT Article DE Sea level rise; Impact; Engineering design; Uncertainty; Flood defense; Probabilistic; Bayesian ID FLOOD RISK; UNCERTAINTY; LESSONS AB The real impact of sea level rise (SLR) on coastal and ocean engineering infrastructures is anticipated to be significant. The associated huge costs of coastal flooding and lasting socio-economic crisis would require planners, decision-makers and engineers to use effectively all available knowledge and data to optimize flood defense protection systems. In this paper, we introduce a Bayesian approach that integrates knowledge from previous performance history of structures (data, models and analysis) with more recent information from the simulations performed using the latest data, methods and modeling technology. These two sets of knowledge and information on past and present status of system contain various uncertainties and errors introduced by different input sources and analysis methods. We employ the concept of global uncertainty to quantify the total uncertainty affecting the design, functionality and maintenance of coastal flood defense systems in order to reduce damages resulting from the SLR and other extreme water level changes (e.g., storm surges by hurricanes, increased precipitation and ice melting). Our objective in this paper is to show coastal engineers how to use the prior knowledge with the most current information to improve the safety of flood defense systems. We demonstrate the proposed method in an example for the failure analysis of the 17th Street Flood Wall in New Orleans, where we estimate uncertainties that affected the design of the l-wall. We provide a methodology that integrates the contribution of SLR with all other available prior information to determine uncertainty levels for failure analysis of the flood defenses. Various uncertainties are present in engineering practice, explicit or implicit, and quantification of these is essential to safety and efficacy of coastal flood protection systems. (C) 2013 Elsevier Ltd. All rights reserved. C1 [Rajabalinejad, M.] Delft Univ Technol, Dept Design Engn, NL-2600 AA Delft, Netherlands. [Demirbilek, Z.] US Army Engineer R&D Ctr, Coastal & Hydraul Lab, Vicksburg, MS USA. RP Rajabalinejad, M (reprint author), Delft Univ Technol, Dept Design Engn, NL-2600 AA Delft, Netherlands. EM M.Rajabalinejad@tudelft.nl; zeki.demirbilek@usace.army.mil NR 39 TC 1 Z9 1 U1 2 U2 43 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0029-8018 J9 OCEAN ENG JI Ocean Eng. PD OCT 1 PY 2013 VL 71 BP 66 EP 73 DI 10.1016/j.oceaneng.2013.05.001 PG 8 WC Engineering, Marine; Engineering, Civil; Engineering, Ocean; Oceanography SC Engineering; Oceanography GA 208PH UT WOS:000323691100008 ER PT J AU Negara, MA Djara, V O'Regan, TP Cherkaoui, K Burke, M Gomeniuk, YY Schmidt, M O'Connor, E Povey, IM Quinn, AJ Hurley, PK AF Negara, M. A. Djara, V. O'Regan, T. P. Cherkaoui, K. Burke, M. Gomeniuk, Y. Y. Schmidt, M. O'Connor, E. Povey, I. M. Quinn, A. J. Hurley, P. K. TI Investigation of electron mobility in surface-channel Al2O3/In0.53Ga0.47As MOSFETs SO SOLID-STATE ELECTRONICS LA English DT Article DE InGaAs; Mobility; MOSFET; High-k; Interface traps; Pulsed I-d - V-g ID IN0.53GA0.47AS MOSFETS; EXTRACTION; SI AB We report on the mechanisms limiting the electron mobility in surface-channel Al2O3/InGaAs MOSFETs. The electron mobility was obtained using pulsed I-d - V-g and split C-V measurements. The energy profile of the density of interface states along with the equivalent-surface density of fixed positive oxide charge were obtained from the modeling of the gate-to-channel capacitance versus gate voltage (C-gc - V-g) characteristic. The experimental C-gc - V-g characteristic was modeled using a self-consistent Poisson-Schrodinger solver, while the electron mobility was calculated using the Kubo-Greenwood formula with nonparabolic corrections. Even when taking into account the impact of fixed oxide charges, Al2O3/In0.53Ga0.47As interface states within the In0.53Ga0.47As energy gap and aligned with the conduction band and the impact of remote phonon scattering, the mobility calculations revealed that the Al2O3/In0.53Ga0.47As surface roughness was the dominant mechanism limiting the electron mobility at high inversion charge density. The values of surface roughness predicted from the combined modeling and experimental results were confirmed by atomic force microscopy measurements and the process step responsible for the increased InGaAs surface roughness was identified. (c) 2013 Elsevier Ltd. All rights reserved. C1 [Negara, M. A.; Djara, V.; Cherkaoui, K.; Burke, M.; Schmidt, M.; O'Connor, E.; Povey, I. M.; Quinn, A. J.; Hurley, P. K.] Natl Univ Ireland Univ Coll Cork, Tyndall Natl Inst, Cork, Ireland. [O'Regan, T. P.] US Army Res Lab, RDRL SER E, Gen Tech Serv, Adelphi, MD 20783 USA. [Gomeniuk, Y. Y.] Natl Acad Sci Ukraine, Lashkaryov Inst Semicond Phys, Kiev, Ukraine. RP Negara, MA (reprint author), Natl Univ Ireland Univ Coll Cork, Tyndall Natl Inst, Cork, Ireland. EM adi.negara@tyndall.ie RI Povey, Ian/C-6439-2009; Cherkaoui, Karim/A-4183-2014; Schmidt, Michael/J-1662-2012; Negara, Muhammad Adi/A-6594-2011; Burke, Micheal/H-9345-2016 OI Povey, Ian/0000-0002-7877-6664; Cherkaoui, Karim/0000-0002-7062-5570; Schmidt, Michael/0000-0002-5601-460X; Burke, Micheal/0000-0003-1831-8829 FU Science Foundation Ireland under the FORME Strategic Research Cluster Award [07/SRC/I1172F]; Irish Research Council for Science, Engineering and Technology (IRCSET)-Marie Curie International Mobility Fellowship in Science, Engineering and Technology; Irish Higher Education Authority PRTLI programme (Cycle 3 "Nanoscience"); Irish Higher Education Authority PRTLI programme (Cycle 4 "INSPIRE") FX This work was supported by Science Foundation Ireland under the FORME Strategic Research Cluster Award number 07/SRC/I1172F, the Irish Research Council for Science, Engineering and Technology (IRCSET)-Marie Curie International Mobility Fellowship in Science, Engineering and Technology and the Irish Higher Education Authority PRTLI programmes (Cycle 3 "Nanoscience" and Cycle 4 "INSPIRE"). NR 23 TC 3 Z9 3 U1 0 U2 37 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0038-1101 J9 SOLID STATE ELECTRON JI Solid-State Electron. PD OCT PY 2013 VL 88 BP 37 EP 42 DI 10.1016/j.sse.2013.04.014 PG 6 WC Engineering, Electrical & Electronic; Physics, Applied; Physics, Condensed Matter SC Engineering; Physics GA 210WK UT WOS:000323865300008 ER PT J AU Dietrich, JC Zijlema, M Allier, PE Holthuijsen, LH Booij, N Meixner, JD Proft, JK Dawson, CN Bender, CJ Naimaster, A Smith, JM Westerink, JJ AF Dietrich, J. C. Zijlema, M. Allier, P. -E. Holthuijsen, L. H. Booij, N. Meixner, J. D. Proft, J. K. Dawson, C. N. Bender, C. J. Naimaster, A. Smith, J. M. Westerink, J. J. TI Limiters for spectral propagation velocities in SWAN SO OCEAN MODELLING LA English DT Article DE Wave-current interaction; Refraction; SWAN; Numerical accuracy ID 3RD-GENERATION WAVE MODEL; STORM-SURGE; SHALLOW-WATER; SOUTHERN LOUISIANA; CHARLESTON HARBOR; HURRICANE-KATRINA; COASTAL REGIONS; COMPUTATIONS; SIMULATIONS; VALIDATION AB As phase-averaged spectral wave models continue to grow in sophistication, they are applied more frequently throughout the ocean, from the generation of waves in deep water to their dissipation in the nearshore. Mesh spacings are varied within the computational domain, either through the use of nested, structured meshes or a single, unstructured mesh. This approach is economical, but it can cause accuracy errors in regions where the input parameters are under-resolved. For instance, in regions with a coarse representation of bathymetry, refraction can focus excessive wave energy at a single mesh vertex, causing the computed solution to become non-physical. Limiters based on the Courant-Friedrichs-Lewy (CFL) criteria are proposed for the spectral propagation (refraction and frequency shifting) velocities in SWAN. These limiters are not required for model stability, but they improve accuracy by reducing local errors that would otherwise spread throughout the computational domain. As demonstrated on test cases in deep and shallow water, these limiters prevent the excessive directional turning and frequency shifting of wave energy and control the largest errors in under-resolved regions. (C) 2012 Elsevier Ltd. All rights reserved. C1 [Dietrich, J. C.; Allier, P. -E.; Meixner, J. D.; Proft, J. K.; Dawson, C. N.] Univ Texas Austin, Inst Computat Engn & Sci, Austin, TX 78712 USA. [Zijlema, M.; Holthuijsen, L. H.; Booij, N.] Delft Univ Technol, Fac Civil Engn, NL-2600 AA Delft, Netherlands. [Bender, C. J.; Naimaster, A.] Taylor Engn, Jacksonville, FL USA. [Smith, J. M.] US Army Corps Engineers, Coastal & Hydraul Lab, Vicksburg, MS USA. [Westerink, J. J.] Univ Notre Dame, Dept Civil & Environm Engn & Earth Sci, Notre Dame, IN 46556 USA. RP Dietrich, JC (reprint author), Univ Texas Austin, Inst Computat Engn & Sci, Austin, TX 78712 USA. EM dietrich@ices.utexas.edu RI Dietrich, Joel/E-5161-2011; Zijlema, Marcel/J-3099-2013 OI Dietrich, Joel/0000-0001-5294-2874; FU National Science Foundation [DMS-0915223] FX This work was supported with funding from the National Science Foundation (DMS-0915223). The realistic wind fields for the Katrina and Hugo applications were developed by OceanWeather, Inc. The South Carolina Department of Natural Resources (SCDNR) provided access to the mesh and storm files applied for the South Carolina coastal analysis. NR 58 TC 16 Z9 19 U1 2 U2 17 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1463-5003 J9 OCEAN MODEL JI Ocean Model. PD OCT PY 2013 VL 70 BP 85 EP 102 DI 10.1016/j.ocemod.2012.11.005 PG 18 WC Meteorology & Atmospheric Sciences; Oceanography SC Meteorology & Atmospheric Sciences; Oceanography GA 209RF UT WOS:000323776800009 ER PT J AU Finch, R AF Finch, Ray TI Barbarossa Derailed: The Battle for Smolensk 10 July-10 September 1941, vol 2 SO RUSSIAN REVIEW LA English DT Book Review C1 [Finch, Ray] Foreign Mil Studies Off, Ft Leavenworth, KS USA. RP Finch, R (reprint author), Foreign Mil Studies Off, Ft Leavenworth, KS USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0036-0341 J9 RUSS REV JI Russ. Rev. PD OCT PY 2013 VL 72 IS 4 BP 702 EP 703 PG 2 WC History SC History GA 209AA UT WOS:000323723800041 ER PT J AU Behler, KD Pesce-Rodriguez, R Cabalo, J Sausa, R AF Behler, K. D. Pesce-Rodriguez, R. Cabalo, J. Sausa, R. TI Infrared spectroscopy and Density Functional Theory of crystalline beta-2,4,6,8,10,12-hexanitrohexaaziosowurtzitane (beta CL-20) in the region of its C-H stretching vibrations SO SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY LA English DT Article ID PRESSURE PHASE-TRANSITION; ENERGETIC MATERIALS; EPSILON-HNIW; PLS REGRESSION; HEXANITROHEXAAZAISOWURTZITANE; EXPLOSIVES; POLYMORPHS; MOLECULES; DFT; FORMULATIONS AB Molecular vibrational spectroscopy provides a useful tool for material characterization and model verification. We examine the CH stretching fundamental and overtones of energetic material beta-2,4,6,8,10,12-hexanitrohexaaziosowurtzitane (beta-CL-20) by Raman spectroscopy, Fourier Transform Infrared Spectroscopy, and Laser Photoacoustic Overtone Spectroscopy, and utilize Density Functional Theory to calculate the C-H bond energy of beta-CL-20 in a crystal. The spectra reveal four intense and distinct features, whose analysis yields C-H stretching fundamental frequencies and anharmonicity values that range from 3137 to 3170 cm(-1) and 53.8 to 58.8 cm(-1), respectively. From these data, we estimate an average value of 42,700 cm(-1) (5.29 eV) for the C-H bond energy, a value that agrees with our quantum mechanical calculations. Published by Elsevier B.V. C1 [Behler, K. D.] US Army Res Lab, ARL RDL WMM A, Aberdeen Proving Ground, MD 21005 USA. [Pesce-Rodriguez, R.; Sausa, R.] US Army Res Lab, ARL RDL WML B, Aberdeen Proving Ground, MD 21005 USA. [Cabalo, J.] Edgewood Chem Biol Ctr, RDCB DRI I, Aberdeen Proving Ground, MD 21010 USA. RP Sausa, R (reprint author), US Army Res Lab, ARL RDL WML B, Aberdeen Proving Ground, MD 21005 USA. EM rosario.c.sausa.civ@mail.mil FU ARL-Bowhead Science & Technology Program FX We gratefully acknowledge computer time at the Army Research Laboratory DoD Supercomputing Research Center (ARL-DSRC) made available through the User Productivity Enhancement, Technology, Transfer, and Training (PETT) Program, and support from the ARL-Bowhead Science & Technology Program. NR 36 TC 0 Z9 0 U1 1 U2 23 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 1386-1425 J9 SPECTROCHIM ACTA A JI Spectroc. Acta Pt. A-Molec. Biomolec. Spectr. PD OCT PY 2013 VL 114 BP 708 EP 712 DI 10.1016/j.saa.2013.05.075 PG 5 WC Spectroscopy SC Spectroscopy GA 204UN UT WOS:000323396800089 PM 23832164 ER PT J AU Clayton, JD AF Clayton, J. D. TI Nonlinear Eulerian thermoelasticity for anisotropic crystals SO JOURNAL OF THE MECHANICS AND PHYSICS OF SOLIDS LA English DT Article DE Nonlinear elasticity; Finite strain; Anisotropy; Crystals; Shock physics ID FINITE STRAIN THEORY; ORDER ELASTIC-CONSTANTS; SHOCK-WAVE; DYNAMIC COMPRESSION; ANHARMONIC THEORY; CUBIC-CRYSTALS; HIGH-PRESSURE; THIRD-ORDER; STABILITY; QUARTZ AB A complete continuum thermoelastic theory for large deformation of crystals of arbitrary symmetry is developed. The theory incorporates as a fundamental state variable in the thermodynamic potentials what is termed an Eulerian strain tensor (in material coordinates) constructed from the inverse of the deformation gradient. Thermodynamic identities and relationships among Eulerian and the usual Lagrangian material coefficients are derived, significantly extending previous literature that focused on materials with cubic or hexagonal symmetry and hydrostatic loading conditions. Analytical solutions for homogeneous deformations of ideal cubic crystals are studied over a prescribed range of elastic coefficients; stress states and intrinsic stability measures are compared. For realistic coefficients, Eulerian theory is shown to predict more physically realistic behavior than Lagrangian theory under large compression and shear. Analytical solutions for shock compression of anisotropic single crystals are derived for internal energy functions quartic in Lagrangian or Eulerian strain and linear in entropy; results are analyzed for quartz, sapphire, and diamond. When elastic constants of up to order four are included, both Lagrangian and Eulerian theories are capable of matching Hugoniot data. When only the second-order elastic constant is known, an alternative theory incorporating a mixed Eulerian-Lagrangian strain tensor provides a reasonable approximation of experimental data. Published by Elsevier Ltd. C1 US Army, Res Lab, RDRL WMP C, Aberdeen Proving Ground, MD 21005 USA. RP Clayton, JD (reprint author), US Army, Res Lab, RDRL WMP C, Aberdeen Proving Ground, MD 21005 USA. EM john.d.clayton1.civ@mail.mil RI Clayton, John/C-7760-2009 NR 72 TC 14 Z9 14 U1 4 U2 30 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0022-5096 EI 1873-4782 J9 J MECH PHYS SOLIDS JI J. Mech. Phys. Solids PD OCT PY 2013 VL 61 IS 10 BP 1983 EP 2014 DI 10.1016/j.jmps.2013.05.009 PG 32 WC Materials Science, Multidisciplinary; Mechanics; Physics, Condensed Matter SC Materials Science; Mechanics; Physics GA 204XG UT WOS:000323404000002 ER PT J AU Spurgers, KB Hurt, CR Cohen, JW Eccelston, LT Lind, CM Lingappa, VR Glass, PJ AF Spurgers, Kevin B. Hurt, Clarence R. Cohen, Jeffrey W. Eccelston, Lori T. Lind, Cathleen M. Lingappa, Vishwanath R. Glass, Pamela J. TI Validation of a cell-based ELISA as a screening tool identifying anti-alphavirus small-molecule inhibitors SO JOURNAL OF VIROLOGICAL METHODS LA English DT Article DE ELISA; Alphavirus; Small-molecule inhibitor; Screen; Virus yield reduction assay; Venezuelan equine encephalitis virus (VEEV) ID VIRUS; CHIKUNGUNYA; REPLICATION; EPIDEMIC; ANALOGS AB Venezuelan (VEEV), eastern, and western equine encephalitis viruses, members of the genus Alphavirus, are causative agents of debilitative and sometimes fatal encephalitis. Although human cases are rare, these viruses pose a threat to military personnel, and to public health, due to their potential use as bioweapons. Currently, there are no licensed therapeutics for treating alphavirus infections. To address this need, small-molecules with potential anti-alphavirus activity, provided by collaborators, are tested routinely in live alphavirus assays utilizing time-consuming virus yield-reduction assays. To expedite the screening/hit-confirmation process, a cell-based enzyme-linked immunosorbent assay (ELISA) was developed and validated for the measurement of VEEV infection. A signal-to-background ratio of >900, and a z-factor of >0.8 indicated the robustness of this assay. For validation, the cell-based ELISA was compared directly to results from virus yield reduction assays in a single dose screen of 21 compounds. Using stringent criteria for anti-VEEV activity there was 90% agreement between the two assays (compounds displaying either antiviral activity, or no effect, in both assays). A concurrent compound-induced cell toxicity assay effectively filtered out false-positive hits. The cell-based ELISA also reproduced successfully compound dose response virus inhibition data observed using the virus yield reduction assay. With available antibodies, this assay can be adapted readily to other viruses of interest to the biodefense community. Additionally, it is cost-effective, rapid, and amenable to automation and scale-up. Therefore, this assay could expedite greatly screening efforts and the identification of effective anti-alphavirus inhibitors. Published by Elsevier B.V. C1 [Spurgers, Kevin B.; Cohen, Jeffrey W.; Eccelston, Lori T.; Lind, Cathleen M.; Glass, Pamela J.] US Army, Med Res Inst Infect Dis, Frederick, MD 21702 USA. [Hurt, Clarence R.; Lingappa, Vishwanath R.] Prosetta Antiviral Inc, San Francisco, CA 94107 USA. RP Glass, PJ (reprint author), US Army, Med Res Inst Infect Dis, 1425 Porter St, Ft Detrick, MD 21702 USA. EM pamela.j.glass.civ@mail.mil FU Defense Threat Reduction Agency (DTRA) [CBM.THRV.01.10.RD.017] FX The authors would like to thank Diana Fisher for her scientific input and statistical analysis, as well as Elaine Morazzani and Victor Rivera for critical review of the paper. Opinions, interpretations, conclusions, and recommendations are those of the authors and are not necessarily endorsed by the U.S. Army. During a portion of this research, KBS was appointed to the Postgraduate Research Participation Program administered by the Oak Ridge Institute for Science and Education (ORISE) through an interagency agreement between the U.S. Department of Energy and USAMRMC. VRL is founder, Chief Technology Officer and Co-CEO of Prosetta Antiviral, Inc. This work was supported in part by the Defense Threat Reduction Agency (DTRA); project number CBM.THRV.01.10.RD.017. NR 13 TC 4 Z9 4 U1 2 U2 18 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0166-0934 J9 J VIROL METHODS JI J. Virol. Methods PD OCT PY 2013 VL 193 IS 1 BP 226 EP 231 DI 10.1016/j.jviromet.2013.06.007 PG 6 WC Biochemical Research Methods; Biotechnology & Applied Microbiology; Virology SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology; Virology GA 204JR UT WOS:000323362100036 PM 23764417 ER PT J AU Sanchez, CJ Prieto, EM Krueger, CA Zienkiewicz, KJ Romano, DR Ward, CL Akers, KS Guelcher, SA Wenke, JC AF Sanchez, Carlos J., Jr. Prieto, Edna M. Krueger, Chad A. Zienkiewicz, Katarzyna J. Romano, Desiree R. Ward, Catherine L. Akers, Kevin S. Guelcher, Scott A. Wenke, Joseph C. TI Effects of local delivery of D-amino acids from biofilm-dispersive scaffolds on infection in contaminated rat segmental defects SO BIOMATERIALS LA English DT Article DE Biofilm; Staphylococcus aureus; Dispersal agent; Osteomyelitis; Open fracture; Scaffold ID BIODEGRADABLE POLYURETHANE SCAFFOLDS; RESISTANT STAPHYLOCOCCUS-AUREUS; IN-VITRO; BACTERIAL BIOFILMS; CONTROLLED-RELEASE; DISEASES SOCIETY; GROWTH-FACTOR; SOL-GEL; OSTEOMYELITIS; ANTIBIOTICS AB Infectious complications of open fractures continue to be a significant factor contributing to non-osseous union and extremity amputation. The persistence of bacteria within biofilms despite meticulous debridement and antibiotic therapy is believed to be a major cause of chronic infection. Considering the difficulties in treating biofilm-associated infections, the use of biofilm dispersal agents as a therapeutic strategy for the prevention of biofilm-associated infections has gained considerable interest. In this study, we investigated whether local delivery of D-Amino Acids (D-AAs), a biofilm dispersal agent, protects scaffolds from contamination and reduces microbial burden within contaminated rat segmental defects in vivo. In vitro testing on biofilms of clinical isolates of Staphylococcus aureus demonstrated that D-Met, D-Phe, D-Pro, and D-Trp were highly effective at dispersing and preventing biofilm formation individually, and the effect was enhanced for an equimolar mixture of D-AAs. Incorporation of D-AAs into polyurethane scaffolds as a mixture (1:1:1 D-Met:D-Pro:D-Trp) significantly reduced bacterial contamination on the scaffold surface in vitro and within bone when implanted into contaminated femoral segmental defects. Our results underscore the potential of local delivery of D-AAs for reducing bacterial contamination by targeting bacteria within biofilms, which may represent a treatment strategy for improving healing outcomes associated with open fractures. Published by Elsevier Ltd. C1 [Sanchez, Carlos J., Jr.; Krueger, Chad A.; Romano, Desiree R.; Ward, Catherine L.; Akers, Kevin S.; Wenke, Joseph C.] United States Army Inst Surg Res, Extrem Trauma & Regenerat Med Task Area, Ft Sam Houston, TX USA. [Prieto, Edna M.; Guelcher, Scott A.] Vanderbilt Univ, Dept Chem & Biomol Engn, Nashville, TN 37235 USA. [Prieto, Edna M.; Zienkiewicz, Katarzyna J.; Guelcher, Scott A.] Vanderbilt Univ, Med Ctr, Ctr Bone Biol, Nashville, TN USA. [Guelcher, Scott A.] Vanderbilt Univ, Dept Biomed Engn, Nashville, TN 37235 USA. RP Wenke, JC (reprint author), US Army Inst Surg Res, Dept Extrem Trauma & Regenerat Med, 3698 Chamber Pass, Ft Sam Houston, TX 78234 USA. EM joseph.c.wenke.civ@mail.mil FU Combat Casualty Research Program, Medical Research and Material Command; Orthopaedic Extremity Trauma Research Program [W81XWH-07-1-0211] FX This work was supported by intramural funding from the Combat Casualty Research Program, Medical Research and Material Command to JCW and by the Orthopaedic Extremity Trauma Research Program (Grant Number W81XWH-07-1-0211) to SAG and JCW. The opinions or assertions contained herein are the private views of the author and are not to be construed as official or as reflecting the views of the Department of the Army or the Department of Defense. NR 71 TC 20 Z9 21 U1 2 U2 51 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0142-9612 J9 BIOMATERIALS JI Biomaterials PD OCT PY 2013 VL 34 IS 30 BP 7533 EP 7543 DI 10.1016/j.biomaterials.2013.06.026 PG 11 WC Engineering, Biomedical; Materials Science, Biomaterials SC Engineering; Materials Science GA 198OJ UT WOS:000322931900032 PM 23831189 ER PT J AU Chen, D Lin, CJ Jones, RG Patel, S Smith, R Simons, K Davis, JL Waisner, SA AF Chen, Dong Lin, Che-Jen Jones, R. Gavin Patel, Sehul Smith, Rachelle Simons, Kelsie Davis, Jeffrey L. Waisner, Scott A. TI A deployable decentralized biofilm system for degrading organic carbon and benzene in wastewater SO ENVIRONMENTAL PROGRESS & SUSTAINABLE ENERGY LA English DT Article DE decentralized wastewater treatment; deployable; Gordonia; attached growth; benzene ID SUBSTRATE INTERACTIONS; BIODEGRADATION; HEADSPACE; REMOVAL; TOLUENE; XYLENE; BTEX AB A fixed biofilm system was explored for decentralized wastewater treatment utilizing laboratory cultivated microorganisms including Gordonia sp. The system is deployable in a 40-ft ISO container/trailer or on a C-130 aircraft. Experimental results indicated that pre-addition of raw wastewater to the microbial culture before inoculation resulted in a significantly higher BOD5 degradation (77 +/- 2% in 24 h) than the consortium alone (58 +/- 10%) during the startup of the system. After the pilot system was in semi-continuous operation with an average flow rate of 13.2 L/min, the removal efficiency of BOD5 and total suspended solids (TSS) was 83 +/- 9 and 84 +/- 9, respectively. As an important supplement to the pilot studies, laboratorial tests by headspace analysis showed that the Gordonia sp. were able to degrade benzene in water. More significant biodegradation of benzene was found in sessile form (57 +/- 8%) than in planktonic form (25 +/- 11%) with minimal glucose in 26 h. However, no benzene degradation was found in sessile form when no glucose was supplied. (c) 2012 American Institute of Chemical Engineers Environ Prog, 32: 505-511, 2013 C1 [Chen, Dong] Indiana Univ Purdue Univ, Dept Engn, Ft Wayne, IN 46805 USA. [Lin, Che-Jen; Patel, Sehul] Lamar Univ, Dept Civil Engn, Beaumont, TX 77710 USA. [Jones, R. Gavin; Smith, Rachelle; Simons, Kelsie] Sam Houston State Univ, Texas Res Inst Environm Studies, Huntsville, TX 77340 USA. [Davis, Jeffrey L.; Waisner, Scott A.] US Army Engn Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA. RP Lin, CJ (reprint author), Lamar Univ, Dept Civil Engn, Beaumont, TX 77710 USA. RI Lin, Che-Jen/K-1808-2013; OI Lin, Che-Jen/0000-0001-5990-3093; Waisner, Scott/0000-0003-4360-4712 FU Engineer Research and Development Center of the US Army Corps of Engineers under Sam Houston State University [W912HZ-07-2-0010] FX This study is supported by the Engineer Research and Development Center of the US Army Corps of Engineers under a subcontract issued by the Sam Houston State University (Project No: W912HZ-07-2-0010). The authors would like to thank Dr. Thomas Chasteen (SHSU) for reviewing the manuscript, Mr. Sabin Holland for his assistance in project coordination, Mr. Joshua Quinn and Mr. Micheal Radib for their assistance in the field work. NR 28 TC 2 Z9 2 U1 1 U2 33 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1944-7442 J9 ENVIRON PROG SUSTAIN JI Environ. Prog. Sustain. Energy PD OCT PY 2013 VL 32 IS 3 BP 505 EP 511 DI 10.1002/ep.11650 PG 7 WC GREEN & SUSTAINABLE SCIENCE & TECHNOLOGY; Engineering, Environmental; Engineering, Chemical; Engineering, Industrial; Environmental Sciences SC Science & Technology - Other Topics; Engineering; Environmental Sciences & Ecology GA 181VH UT WOS:000321697000012 ER PT J AU Zhang, YN Zhang, HC Nasrabadi, NM Huang, TS AF Zhang, Yanning Zhang, Haichao Nasrabadi, Nasser M. Huang, Thomas S. TI Multi-metric learning for multi-sensor fusion based classification SO INFORMATION FUSION LA English DT Article DE Metric learning; Multi-sensor fusion; Joint classification ID NEAREST-NEIGHBOR CLASSIFICATION; DIMENSIONALITY REDUCTION; SYSTEMS AB In this paper, we propose a multiple-metric learning algorithm to learn jointly a set of optimal homogenous/heterogeneous metrics in order to fuse the data collected from multiple sensors for joint classification. The learned metrics have the potential to perform better than the conventional Euclidean metric for classification. Moreover, in the case of heterogenous sensors, the learned multiple metrics can be quite different, which are adapted to each type of sensor. By learning the multiple metrics jointly within a single unified optimization framework, we can learn better metrics to fuse the multi-sensor data for a joint classification. Furthermore, we also exploit multi-metric learning in a kernel induced feature space to capture the non-linearity in the original feature space via kernel mapping. (c) 2012 Elsevier B.V. All rights reserved. C1 [Zhang, Yanning; Zhang, Haichao] Northwestern Polytech Univ, Sch Comp Sci, Xian 710072, Peoples R China. [Zhang, Haichao; Huang, Thomas S.] Univ Illinois, Beckman Inst, Urbana, IL USA. [Nasrabadi, Nasser M.] USA, Res Lab, Adelphi, MD USA. RP Zhang, HC (reprint author), Northwestern Polytech Univ, Sch Comp Sci, Xian 710072, Peoples R China. EM hczhang1@gmail.com FU NSF [60872145, 60903126]; National High-Tech. [2009AA01Z315]; Postdoctoral (Special) Science Foundation [20090451397, 201003685]; Cultivation Fund from Ministry of Education of China [708085]; U.S. Army Research Laboratory; U.S. Army Research Office [W911NF-09-1-0383] FX We would like to thank the all the anonymous reviewers for their valuable comments. This work is supported by NSF (60872145, 60903126), National High-Tech. (2009AA01Z315), Postdoctoral (Special) Science Foundation (20090451397, 201003685) and Cultivation Fund from Ministry of Education (708085) of China. This work is also supported by U.S. Army Research Laboratory and U.S. Army Research Office under Grant No. W911NF-09-1-0383. NR 32 TC 4 Z9 5 U1 6 U2 44 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1566-2535 J9 INFORM FUSION JI Inf. Fusion PD OCT PY 2013 VL 14 IS 4 BP 431 EP 440 DI 10.1016/j.inffus.2012.05.002 PG 10 WC Computer Science, Artificial Intelligence; Computer Science, Theory & Methods SC Computer Science GA 178XN UT WOS:000321480800010 ER PT J AU Rice, BM Byrd, EFC AF Rice, Betsy M. Byrd, Edward F. C. TI Evaluation of electrostatic descriptors for predicting crystalline density SO JOURNAL OF COMPUTATIONAL CHEMISTRY LA English DT Article DE quantum chemistry; density functional theory; energetic materials; crystal density; electrostatic potential ID ENERGETIC SALTS; FORMULA; VOLUMES; HEATS AB This study evaluates the importance of electrostatic corrections to earlier quantum-mechanically based methods to predict crystal densities of neutral and ionic molecular energetic materials. Our previous methods (B. M. Rice et al., J. Phys. Chem. A 2007, 111, 10874) use the molecular volumes of the isolated molecule or formula unit to estimate the crystal density; this volume is defined to be that inside the quantum-mechanically determined 0.001 a.u. isosurface of electron density surrounding the isolated molecule. The electrostatic corrections to these volumetric estimates are based on features of the electrostatic potential mapped onto this isosurface of electron density, and have been parameterized using information from 180 neutral and 23 ionic CHNO molecular systems. The quality of the electrostatically corrected methods was assessed through application to 38 neutral and 48 ionic compounds not used in the parameterization. The root mean square (rms) percent deviation and average absolute error of predictions for the 38 neutral species relative to experiment are 2.7% and 0.035 g/cm(3), respectively, decreases of 0.9% and 0.015 g/cm(3) from the earlier predictions (3.6% and 0.050 g/cm(3), respectively). The rms percent deviation and average absolute error of predictions for the 48 ionic compounds relative to experiment are 3.7% and 0.045 g/cm(3), respectively, decreases of 2.6% and 0.043 g/cm(3) from the earlier predictions that used the formula unit volumes only. The results clearly show a significant improvement to the earlier method upon inclusion of electrostatic corrections. (c) 2013 Wiley Periodicals, Inc. C1 [Rice, Betsy M.; Byrd, Edward F. C.] US Army Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. RP Rice, BM (reprint author), US Army Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. EM betsy.rice.civ@mail.mil FU Office of Naval Research; Army Environmental Quality Technology Ordnance Program FX This work was partially supported by the Office of Naval Research and the Army Environmental Quality Technology Ordnance Program. All calculations were performed at either the ARL or AFRL DoD Supercomputing Resource Centers of the Department of Defense High Performance Computing Modernization Program. NR 16 TC 20 Z9 22 U1 1 U2 23 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0192-8651 EI 1096-987X J9 J COMPUT CHEM JI J. Comput. Chem. PD SEP 30 PY 2013 VL 34 IS 25 BP 2146 EP 2151 DI 10.1002/jcc.23369 PG 6 WC Chemistry, Multidisciplinary SC Chemistry GA 202JB UT WOS:000323209500002 PM 23813635 ER PT J AU Bickford, JR Yu, PKL Lau, SS AF Bickford, Justin R. Yu, P. K. L. Lau, S. S. TI Thermal and microwave characterization of GaAs to Si metal-bonded structures SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID THIN-FILMS; CONDUCTIVITY; DEVICES AB Isothermal solidification metal waferbonding is well suited to heterogeneously integrate high-speed/high-power density RF and microwave devices with standard CMOS technology. It is capable of forming efficient electrical and thermal interconnects as well as bonded-microstrip waveguide structures. Accurate means of characterizing the electrical, thermal, and microwave properties of these structures are necessary to enable heterogeneous monolithic microwave integrated circuits (HMMICs). This article describes a bond layer thermal conductivity measurement method, a bond-metal microstrip microwave waveguide characterization method, and the fabrication method developed to support the measurement structures. As a result, an In-Pd bond alloy thermal conductivity of 2.51 W/(m K) was measured for GaAs devices bonded to Si. Also, an optimized bonded-microstrip waveguide was simulated based upon measured microwave results of the measurement structure, projecting a 0.56 dB/mm loss, a microwave index of 2.91, and a characteristic impedance of 41.3+6i Omega at 15 GHz, thus advocating this approach as a means of realizing high power HMMICs. (C) 2013 AIP Publishing LLC. C1 [Bickford, Justin R.] US Army Res Lab, Sensors & Electron Devices Directorate, Adelphi Lab Ctr, Adelphi, MD 20783 USA. [Yu, P. K. L.; Lau, S. S.] Univ Calif San Diego, Dept Elect & Comp Engn, San Diego, CA 92093 USA. RP Bickford, JR (reprint author), US Army Res Lab, Sensors & Electron Devices Directorate, Adelphi Lab Ctr, Adelphi, MD 20783 USA. EM justin.r.bickford.civ@mail.mil FU National Science Foundation [ECS0307247]; BAE/APTI; UCSD ECE Departmental Fellowship FX This work was supported in part by National Science Foundation Grant No. ECS0307247 and by BAE/APTI, as well as a UCSD ECE Departmental Fellowship. Thanks go to Arthur Clawson at UCSD for guidance during MOCVD growth and to Ivan Shubin at UCSD for informative discussions on device fabrication. NR 24 TC 0 Z9 0 U1 1 U2 11 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0021-8979 EI 1089-7550 J9 J APPL PHYS JI J. Appl. Phys. PD SEP 28 PY 2013 VL 114 IS 12 AR 123515 DI 10.1063/1.4824063 PG 6 WC Physics, Applied SC Physics GA 231CR UT WOS:000325391100022 ER PT J AU Arun, P Abu-Taleb, R Oguntayo, S Tanaka, M Wang, Y Valiyaveettil, M Long, JB Zhang, YM Nambiar, MP AF Arun, Peethambaran Abu-Taleb, Rania Oguntayo, Samuel Tanaka, Mikiei Wang, Ying Valiyaveettil, Manojkumar Long, Joseph B. Zhang, Yumin Nambiar, Madhusoodana P. TI Distinct patterns of expression of traumatic brain injury biomarkers after blast exposure: Role of compromised cell membrane integrity SO NEUROSCIENCE LETTERS LA English DT Article DE Blast exposure; Cell membrane integrity; GFAP; Tau; Polytrauma ID FIBRILLARY ACIDIC PROTEIN; TOTAL TAU; SERUM; OVERPRESSURE; GFAP AB Glial fibrillary acidic protein (GFAP), a protein enriched in astrocytes, and Tau, a protein abundant in neuronal microtubules, are being widely studied as biomarkers of brain injury, and persistent severity-dependent increases in brain and blood have been reported. Studies on the acute changes of these proteins after blast exposure are limited. Using a mouse model of closely-coupled repeated blast exposures, we have evaluated acute changes in the levels of GFAP and total Tau by Western blotting. Brain levels of GFAP and Tau proteins decreased significantly at 6 h and increased considerably at 24 h after repeated blast exposures. Plasma samples showed a similar initial decrease and later increase over this timeframe. This biphasic pattern points to possible absorption or sequestration of these proteins from plasma immediately after repeated blast exposures. Liver and spleen tissue showed significant increases in the levels of GFAP and Tau protein at 6 and 24 h post-blast exposures whereas semi-quantitative RT-PCR analysis of liver showed no significant changes in the levels of GFAP or Tau mRNAs. These results suggest that blast exposure causes transient changes in cell membrane integrity in multiple organs leading to abnormal migration of proteins from the tissues to the plasma and vice versa. This transient changes in cell membrane permeability and subsequent bidirectional movement of molecules may contribute to the pathophysiology of TBI and polytrauma after blast exposure. (C) 2013 Elsevier Ireland Ltd. All rights reserved. C1 [Arun, Peethambaran; Abu-Taleb, Rania; Oguntayo, Samuel; Wang, Ying; Valiyaveettil, Manojkumar; Long, Joseph B.; Nambiar, Madhusoodana P.] Walter Reed Army Inst Res, Blast Induced Neurotrauma Branch, Ctr Mil Psychiat & Neurosci, Silver Spring, MD 20910 USA. [Tanaka, Mikiei; Zhang, Yumin] Uniformed Serv Univ Hlth Sci, Dept Anat Physiol & Genet, Bethesda, MD 20814 USA. RP Arun, P (reprint author), Walter Reed Army Inst Res, Blast Induced Neurotrauma Branch, Ctr Mil Psychiat & Neurosci, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM peethambaran.arun.ctr@mail.mil NR 28 TC 23 Z9 24 U1 1 U2 13 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0304-3940 EI 1872-7972 J9 NEUROSCI LETT JI Neurosci. Lett. PD SEP 27 PY 2013 VL 552 BP 87 EP 91 DI 10.1016/j.neulet.2013.07.047 PG 5 WC Neurosciences SC Neurosciences & Neurology GA 237YG UT WOS:000325907000018 PM 23933206 ER PT J AU Gottardo, R Bailer, RT Korber, BT Gnanakaran, S Phillips, J Shen, XY Tomaras, GD Turk, E Imholte, G Eckler, L Wenschuh, H Zerweck, J Greene, K Gao, HM Berman, PW Francis, D Sinangil, F Lee, C Nitayaphan, S Rerks-Ngarm, S Kaewkungwal, J Pitisuttithum, P Tartaglia, J Robb, ML Michael, NL Kim, JH Zolla-Pazner, S Haynes, BF Mascola, JR Self, S Gilbert, P Montefiori, DC AF Gottardo, Raphael Bailer, Robert T. Korber, Bette T. Gnanakaran, S. Phillips, Joshua Shen, Xiaoying Tomaras, Georgia D. Turk, Ellen Imholte, Gregory Eckler, Larry Wenschuh, Holger Zerweck, Johannes Greene, Kelli Gao, Hongmei Berman, Phillip W. Francis, Donald Sinangil, Faruk Lee, Carter Nitayaphan, Sorachai Rerks-Ngarm, Supachai Kaewkungwal, Jaranit Pitisuttithum, Punnee Tartaglia, James Robb, Merlin L. Michael, Nelson L. Kim, Jerome H. Zolla-Pazner, Susan Haynes, Barton F. Mascola, John R. Self, Steve Gilbert, Peter Montefiori, David C. TI Plasma IgG to Linear Epitopes in the V2 and V3 Regions of HIV-1 gp120 Correlate with a Reduced Risk of Infection in the RV144 Vaccine Efficacy Trial SO PLOS ONE LA English DT Article ID HUMAN-IMMUNODEFICIENCY-VIRUS; HUMAN MONOCLONAL-ANTIBODIES; DEPENDENT CELLULAR CYTOTOXICITY; RECOMBINANT GLYCOPROTEIN-120 VACCINE; CD4 BINDING-SITE; ENVELOPE PROTEIN; NEUTRALIZING ANTIBODIES; CONFORMATIONAL EPITOPE; TRANSMEMBRANE PROTEIN; BROAD NEUTRALIZATION AB Neutralizing and non-neutralizing antibodies to linear epitopes on HIV-1 envelope glycoproteins have potential to mediate antiviral effector functions that could be beneficial to vaccine-induced protection. Here, plasma IgG responses were assessed in three HIV-1 gp120 vaccine efficacy trials (RV144, Vax003, Vax004) and in HIV-1-infected individuals by using arrays of overlapping peptides spanning the entire consensus gp160 of all major genetic subtypes and circulating recombinant forms (CRFs) of the virus. In RV144, where 31.2% efficacy against HIV-1 infection was seen, dominant responses targeted the C1, V2, V3 and C5 regions of gp120. An analysis of RV144 case-control samples showed that IgG to V2 CRF01_AE significantly inversely correlated with infection risk (OR=0.54, p=0.0042), as did the response to other V2 subtypes (OR=0.60-0.63, p=0.016-0.025). The response to V3 CRF01_AE also inversely correlated with infection risk but only in vaccine recipients who had lower levels of other antibodies, especially Env-specific plasma IgA (OR=0.49, p=0.007) and neutralizing antibodies (OR=0.5, p=0.008). Responses to C1 and C5 showed no significant correlation with infection risk. In Vax003 and Vax004, where no significant protection was seen, serum IgG responses targeted the same epitopes as in RV144 with the exception of an additional C1 reactivity in Vax003 and infrequent V2 reactivity in Vax004. In HIV-1 infected subjects, dominant responses targeted the V3 and C5 regions of gp120, as well as the immunodominant domain, heptad repeat 1 (HR-1) and membrane proximal external region (MPER) of gp41. These results highlight the presence of several dominant linear B cell epitopes on the HIV-1 envelope glycoproteins. They also generate the hypothesis that IgG to linear epitopes in the V2 and V3 regions of gp120 are part of a complex interplay of immune responses that contributed to protection in RV144. C1 [Gottardo, Raphael; Imholte, Gregory; Self, Steve; Gilbert, Peter] Fred Hutchinson Canc Res Ctr, Seattle, WA 98104 USA. [Bailer, Robert T.; Turk, Ellen; Mascola, John R.] NIAID, Vaccine Res Ctr, NIH, Bethesda, MD 20892 USA. [Korber, Bette T.; Gnanakaran, S.; Phillips, Joshua] Los Alamos Natl Lab, Los Alamos, NM USA. [Shen, Xiaoying; Tomaras, Georgia D.; Greene, Kelli; Gao, Hongmei; Haynes, Barton F.; Montefiori, David C.] Duke Univ, Med Ctr, Durham, NC 27710 USA. [Eckler, Larry; Wenschuh, Holger; Zerweck, Johannes] JPT Peptide Technol GmbH, Berlin, Germany. [Berman, Phillip W.] Univ Calif Santa Cruz, Baskin Sch Engn, Santa Cruz, CA 95064 USA. [Francis, Donald; Sinangil, Faruk; Lee, Carter] Global Solut Infect Dis, San Francisco, CA USA. [Nitayaphan, Sorachai] US Army Med Component, Dept Retrovirol, AFRIMS, Bangkok, Thailand. [Rerks-Ngarm, Supachai] Minist Publ Hlth, Dept Dis Control, Nonthaburi, Thailand. [Kaewkungwal, Jaranit] Mahidol Univ, Fac Trop Med, Ctr Excellence Biomed & Publ Hlth Informat BIOPHI, Bangkok, Thailand. [Pitisuttithum, Punnee] Mahidol Univ, Vaccine Trial Ctr, Bangkok 10700, Thailand. [Pitisuttithum, Punnee] Mahidol Univ, Dept Clin Trop Med, Bangkok 10700, Thailand. [Tartaglia, James] Sanofi Pasteur, Dept Res & Dev, Swiftwater, PA USA. [Robb, Merlin L.; Michael, Nelson L.; Kim, Jerome H.] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD USA. [Zolla-Pazner, Susan] Vet Affairs New York Harbor Healthcare Syst, New York, NY USA. [Zolla-Pazner, Susan] NYU, Sch Med, New York, NY USA. RP Montefiori, DC (reprint author), Duke Univ, Med Ctr, Durham, NC 27710 USA. EM david.montefiori@duke.edu RI Tomaras, Georgia/J-5041-2016; OI Gnanakaran, S/0000-0002-9368-3044; Korber, Bette/0000-0002-2026-5757 FU Bill & Melinda Gates Foundation [38619]; U.S. Army Medical Research and Material Command (USAMRMC) [Y1-AI-2642-12]; National Institutes of Allergy and Infectious Diseases [Y1-AI-2642-12]; Department of Veterans Affairs, Veterans Health Administration, Office of Research and Development [Y1-AI-2642-12]; Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. [W81XWH-07-2-0067]; U.S. Department of Defense (DOD) [W81XWH-07-2-0067]; New York University School of Medicine [692526] FX This study was funded in part by a grant from the Bill & Melinda Gates Foundation (#38619) to DCM as part of the Collaboration for AIDS Vaccine Discovery (www.cavd.org), and by an Interagency Agreement Y1-AI-2642-12 between U.S. Army Medical Research and Material Command (USAMRMC), the National Institutes of Allergy and Infectious Diseases, and by the Department of Veterans Affairs, Veterans Health Administration, Office of Research and Development. This work was also supported by a cooperative agreement (W81XWH-07-2-0067) between the Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., and the U.S. Department of Defense (DOD) and New York University School of Medicine (Contract No. 692526). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 93 TC 81 Z9 82 U1 0 U2 12 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD SEP 26 PY 2013 VL 8 IS 9 AR e75665 DI 10.1371/journal.pone.0075665 PG 16 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 228VP UT WOS:000325220000034 PM 24086607 ER PT J AU Traversa, A Loffredo, E Palazzo, AJ Bashore, TL Senesi, N AF Traversa, Andreina Loffredo, Elisabetta Palazzo, Antonio J. Bashore, Terry L. Senesi, Nicola TI Enhancement of Germination and Growth of Slickspot Peppergrass in a New Medium with Two Compost Organic Fractions SO COMMUNICATIONS IN SOIL SCIENCE AND PLANT ANALYSIS LA English DT Article DE Compost; humic acid; slickspot peppergrass; water-extractable organic matter ID LEPIDIUM-PAPILLIFERUM; ACIDS; SOIL AB Slickspot peppergrass (Lepidium papilliferum) is an herbaceous biennal or possibly perennial rare endemic plant of the southwestern Idaho high desert listed as a threatened species. This plant establishes perennial seed banks, with seeds remaining dormant and viable for several years. This study aimed to enhance the germination and early growth of this plant by adopting a new medium, a nutrient-enriched agar solution, also added with humic acid (HA) and water-extractable organic matter (WEOM) fractions isolated from a green compost (GC) and a mixed compost (MC). The germination percentage of slickspot peppergrass in this new medium was much greater than that obtained in previous studies. Further, the addition of GC-HA in the medium enhanced significantly the germination and early growth of this plant. The addition of GC-WEOM and MC-WEOM were beneficial only on plant growth for at least 7 months. C1 [Traversa, Andreina; Loffredo, Elisabetta; Senesi, Nicola] Univ Bari, Dipartimento Biol & Chim Agroforestale & Ambienta, I-70126 Bari, Italy. [Palazzo, Antonio J.] Engineer Res & Dev Ctr, Cold Reg Res & Engn Lab, Hanover, NH USA. [Bashore, Terry L.] Headquarters Air Combat Command Airspace, Airfield Operat Div, Langley AFB, VA USA. RP Loffredo, E (reprint author), Univ Bari, Dipartimento Biol & Chim Agroforestale & Ambienta, I-70126 Bari, Italy. EM loffredo@agr.uniba.it OI Loffredo, Elisabetta/0000-0003-0783-5193 FU U.S. Army RDECOM ACQ CTR-W911NF, Durham, N.C., USA [W911NF-08-1-0076]; Airspace, Ranges; Airfield Operations Division, HQ Air Combat Command, Langley AFB, Va FX This work was supported by Research Contract No. W911NF-08-1-0076 of the U.S. Army RDECOM ACQ CTR-W911NF, Durham, N.C., USA, with the project title "Effects of quality composts and other organic amendments and their humic and fulvic acid fractions on the germination and early growth of slickspot peppergrass (Lepidium papilliferum) and switchgrass in various experimental conditions," funded by the Airspace, Ranges, and Airfield Operations Division, HQ Air Combat Command, Langley AFB, Va. The opinions and conclusions in this article are those of the authors and do not necessarily reflect those of the U.S. Air Force, U.S. Army, or the federal government. NR 15 TC 0 Z9 0 U1 1 U2 15 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA SN 0010-3624 J9 COMMUN SOIL SCI PLAN JI Commun. Soil Sci. Plant Anal. PD SEP 25 PY 2013 VL 44 IS 17 BP 2636 EP 2646 DI 10.1080/00103624.2013.811523 PG 11 WC Agronomy; Plant Sciences; Chemistry, Analytical; Soil Science SC Agriculture; Plant Sciences; Chemistry GA 211PA UT WOS:000323920000013 ER PT J AU Price, SC Ren, XM Jackson, AC Ye, YS Elabd, YA Beyer, FL AF Price, Samuel C. Ren, Xiaoming Jackson, Aaron C. Ye, Yuesheng Elabd, Yossef A. Beyer, Frederick L. TI Bicontinuous Alkaline Fuel Cell Membranes from Strongly Self-Segregating Block Copolymers SO MACROMOLECULES LA English DT Article ID ANION-EXCHANGE MEMBRANES; POLYMER ELECTROLYTE MEMBRANES; SMALL-ANGLE SCATTERING; FUNCTIONALIZED POLYETHYLENE; CARBON-DIOXIDE; PERFORMANCE; MORPHOLOGY; POLYSTYRENE; FILMS; CONDUCTIVITY AB Alkaline fuel cell membranes have the potential to reduce the cost and weight of current fuel cell technology, but they still have not been broadly commercialized due to poor hydroxide conductivities and mechanical properties, in addition to low chemical stability. One approach to address these mechanical and transport shortcomings is forming a morphologically bicontinuous network of an ion transporting phase and a hydrophobic phase to provide mechanical strength. In this report, membranes having bicontinuous morphologies are fabricated by cross-linking cation-containing block copolymers with hydrophobic constituents. This is accomplished in a single step and does not require postpolymerization modification. The resulting materials conduct hydroxide ions very rapidly, as high as 120 mS cm(-1) in liquid water at 60 degrees C. The methodological changes required to obtain a bicontinuous morphology from such strongly self-segregating block copolymers, relevant to other applications in which bicontinuous structures are desired, are also described. C1 [Price, Samuel C.; Jackson, Aaron C.; Beyer, Frederick L.] US Army Res Lab, Weapons & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. [Ren, Xiaoming] US Army Res Lab, Sensors & Elect Devices Directorate, Adelphi, MD 20783 USA. [Ye, Yuesheng; Elabd, Yossef A.] Drexel Univ, Dept Chem & Biol Engn, Philadelphia, PA 19104 USA. RP Beyer, FL (reprint author), US Army Res Lab, Weapons & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. EM Frederick.L.Beyer3.civ@mail.mil RI ren, xiaoming/F-3953-2011; Elabd, Yossef/G-9866-2014 OI Elabd, Yossef/0000-0002-7790-9445 FU Postgraduate Research Participation Program at the US Army Research Laboratory; US Department of Energy [ORISE 1120-1120-99]; Army Research Laboratory [ORISE 1120-1120-99]; U.S. Army Research Laboratory Materials Center of Excellence at Drexel University [W911NF-06-2-0013] FX We acknowledge Kenneth Strawhecker and Ian McAninich for their assistance and helpful discussions. S.C.P. and A.C.J. were supported by the Postgraduate Research Participation Program at the US Army Research Laboratory, administered by the Oak Ridge Institute of Science and Education through an inter-agency agreement between the US Department of Energy and Army Research Laboratory (Contract ORISE 1120-1120-99). Portions of this work were supported by the U.S. Army Research Laboratory Materials Center of Excellence at Drexel University, under Grant W911NF-06-2-0013. NR 61 TC 25 Z9 26 U1 5 U2 60 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0024-9297 EI 1520-5835 J9 MACROMOLECULES JI Macromolecules PD SEP 24 PY 2013 VL 46 IS 18 BP 7332 EP 7340 DI 10.1021/ma400995n PG 9 WC Polymer Science SC Polymer Science GA 295VY UT WOS:000330145700022 ER PT J AU Gibbons, RV Nisalak, A Yoon, IK Tannitisupawong, D Rungsimunpaiboon, K Vaughn, DW Endy, TP Innis, BL Burke, DS Mammen, MP Scott, RM Thomas, SJ Hoke, CH AF Gibbons, Robert V. Nisalak, Ananda Yoon, In-Kyu Tannitisupawong, Darunee Rungsimunpaiboon, Kamchai Vaughn, David W. Endy, Timothy P. Innis, Bruce L. Burke, Donald S. Mammen, Mammen P., Jr. Scott, Robert McNair Thomas, Stephen J. Hoke, Charles H., Jr. TI A model international partnership for community-based research on vaccine-preventable diseases: The Kamphaeng Phet-AFRIMS Virology Research Unit (KAVRU) SO VACCINE LA English DT Review DE Vaccine efficacy trials; Site selection; Japanese encephalitis vaccine; Hepatitis A vaccine; Dengue vaccine; Influenza; Collaboration; Team building; Public Health ID JAPANESE ENCEPHALITIS-VIRUS; DENGUE HEMORRHAGIC-FEVER; PRIMARY-SCHOOL CHILDREN; POLYMERASE CHAIN-REACTION; BLOOD MONONUCLEAR-CELLS; HEPATITIS-A VACCINE; AEDES-AEGYPTI; MONOCLONAL-ANTIBODIES; CEREBROSPINAL-FLUID; CHIANGMAI VALLEY AB This paper describes an international collaboration to carry out studies that contributed to the understanding of pathogenesis, diagnosis, treatment, and prevention of several diseases of public health importance for Thailand and the United States. In Kamphaeng Phet Province, Thailand, febrile syndromes, including encephalitis, hepatitis, hemorrhagic fever, and influenza-like illnesses, occurred commonly and were clinically diagnosed, but the etiology was rarely confirmed. Since 1982, the Kamphaeng Phet Provincial Hospital, the Thai Ministry of Public Health, and the US Army Component of the Armed Forces Research Institute of Medical Sciences, along with vaccine manufacturers and universities, have collaborated on studies that evaluated and capitalized on improved diagnostic capabilities for infections caused by Japanese encephalitis, hepatitis A, dengue, and influenza viruses. The collaboration clarified clinical and epidemiological features of these infections and, in large clinical trials, demonstrated that vaccines against Japanese encephalitis and hepatitis A viruses were over 90% efficacious, supporting licensure of both vaccines. With the introduction of Japanese encephalitis vaccines in Thailand's Expanded Program on Immunization, reported encephalitis rates dropped substantially. Similarly, in the US, particularly in the military populations, rates of hepatitis A disease have dropped with the use of hepatitis A vaccine. Studies of the pathogenesis of dengue infections have increased understanding of the role of cellular immunity in responding to these infections, and epidemiological studies have prepared the province for studies of dengue vaccines. Approximately 80 publications resulted from this collaboration. Studies conducted in Kamphaeng Phet provided experience that contributed to clinical trials of hepatitis E and HIV vaccines, conducted elsewhere. To provide a base for continuing studies, The Kamphaeng Phet-AFRIMS Virology Research Unit (KAVRU) was established. This paper reviews the origins of the collaboration and the scientific observations made between 1982 and 2012. (C) 2013 Elsevier Ltd. All rights reserved. C1 [Gibbons, Robert V.; Nisalak, Ananda; Yoon, In-Kyu; Tannitisupawong, Darunee] Armed Forces Res Inst Med Sci, Dept Virol, Bangkok 10400, Thailand. [Rungsimunpaiboon, Kamchai] Kamphaeng Phet Prov Hosp, Kamphaeng Phet, Thailand. [Vaughn, David W.] GlaxoSmithKline Vaccines, Rixensart, Belgium. [Endy, Timothy P.] SUNY Syracuse, Dept Infect Dis, Syracuse, NY USA. [Innis, Bruce L.] GlaxoSmithKline Vaccines, King Of Prussia, PA USA. [Burke, Donald S.] Univ Pittsburgh, Grad Sch Publ Hlth, Pittsburgh, PA USA. [Mammen, Mammen P., Jr.] Vical Inc, San Diego, CA USA. [Thomas, Stephen J.] Walter Reed Army Inst Res, Silver Spring, MD USA. RP Hoke, CH (reprint author), 6405 Cardinal Lane, Columbia, MD USA. EM RobertVGibbons@gmail.com; AnandaN@afrims.org; Inkyu.yoon@afrims.org; DaruneeT@afrims.org; kam.director1@gmail.com; david.w.vaughn@gsk.com; EndyT@upstate.edu; Bruce.2.Innis@GSK.com; DonBurke@pitt.edu; mammen.mammen@vical.com; scottrmcn@cs.net; Stephen.J.Thomas3.mil@mail.mil; CHHokeJr@gmail.com OI /0000-0002-5704-8094 FU US Army Medical Research and Materiel Command; US National Institute of Allergy and Infectious Diseases; Armed Forces Health Surveillance Center, Global Emerging Infections Surveillance and Response System; Thai MOPH; GSK; Sanofi Pasteur FX The US Army Medical Research and Materiel Command, the US National Institute of Allergy and Infectious Diseases, the Armed Forces Health Surveillance Center, Global Emerging Infections Surveillance and Response System, and the Thai MOPH provided funding for the studies described. GSK provided partial funding for the HAV efficacy trial. None of the funding agencies had any influence over the content of this paper. Sanofi Pasteur provided funding for the ongoing dengue vaccine trial. NR 125 TC 1 Z9 1 U1 0 U2 6 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X EI 1873-2518 J9 VACCINE JI Vaccine PD SEP 23 PY 2013 VL 31 IS 41 BP 4487 EP 4500 DI 10.1016/j.vaccine.2013.07.082 PG 14 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 239FP UT WOS:000326008300005 PM 23933334 ER PT J AU Okusaga, O Cahill, JP Docherty, A Menyuk, CR Zhou, W Carter, GM AF Okusaga, Olukayode Cahill, James P. Docherty, Andrew Menyuk, Curtis R. Zhou, Weimin Carter, Gary M. TI Suppression of Rayleigh-scattering-induced noise in OEOs SO OPTICS EXPRESS LA English DT Article ID OPTICAL FREQUENCY; OPTOELECTRONIC OSCILLATOR AB Optoelectronic oscillators (OEOs) are hybrid RF-photonic devices that promise to be environmentally robust high-frequency RF sources with very low phase noise. Previously, we showed that Rayleigh-scattering-induced noise in optical fibers coupled with amplitude-to-phase noise conversion in photodetectors and amplifiers leads to fiber-length-dependent noise in OEOs. In this work, we report on two methods for the suppression of this fiber-length-dependent noise: altering the amplitude-dependent phase delay of the OEO loops and suppressing the Rayleigh-scattering-induced noise in optical fibers. We report a 20 dB reduction in the flicker phase noise of a 6 km OEO via these suppression techniques. (c) 2013 Optical Society of America C1 [Okusaga, Olukayode; Cahill, James P.; Zhou, Weimin] US Army Res Lab, Sensors & Elect Devices Directorate, Adelphi, MD 20783 USA. [Cahill, James P.; Docherty, Andrew; Menyuk, Curtis R.; Carter, Gary M.] Univ Maryland, Dept Comp Sci & Elect Engn, Baltimore, MD 21250 USA. RP Okusaga, O (reprint author), US Army Res Lab, Sensors & Elect Devices Directorate, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM olukayode.k.okusaga.civ@mail.mil NR 15 TC 6 Z9 6 U1 1 U2 19 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1094-4087 J9 OPT EXPRESS JI Opt. Express PD SEP 23 PY 2013 VL 21 IS 19 BP 22255 EP 22262 DI 10.1364/OE.21.022255 PG 8 WC Optics SC Optics GA 233DY UT WOS:000325547200052 PM 24104117 ER PT J AU Hill, SC Pan, YL Williamson, C Santarpia, JL Hill, HH AF Hill, Steven C. Pan, Yong-Le Williamson, Chatt Santarpia, Joshua L. Hill, Hanna H. TI Fluorescence of bioaerosols: mathematical model including primary fluorescing and absorbing molecules in bacteria SO OPTICS EXPRESS LA English DT Article ID BIOLOGICAL AEROSOL-PARTICLES; LASER-INDUCED FLUORESCENCE; ESCHERICHIA-COLI; BACILLUS-SUBTILIS; ASPARTATE-AMINOTRANSFERASE; CROSS-SECTIONS; OPTICAL-PROPERTIES; MU-M; SERINE PALMITOYLTRANSFERASE; INTRINSIC FLUORESCENCE AB This paper describes a mathematical model of fluorescent biological particles composed of bacteria, viruses, or proteins. The fluorescent and/or light absorbing molecules included in the model are amino acids (tryptophan, etc.); nucleic acids (DNA, RNA, etc.); coenzymes (nicotinamide adenine dinucleotides, flavins, and vitamins B-6 and K and variants of these); and dipicolinates. The concentrations, absorptivities, and fluorescence quantum yields are estimated from the literature, often with large uncertainties. The bioparticles in the model are spherical and homogeneous. Calculated fluorescence cross sections for particles excited at 266, 280, and 355 nm are compared with measured values from the literature for several bacteria, bacterial spores and albumins. The calculated 266- and 280-nm excited fluorescence is within a factor of 3.2 of the measurements for the vegetative cells and proteins, but overestimates the fluorescence of spores by a factor of 10 or more. This is the first reported modeling of the fluorescence of bioaerosols in which the primary fluorophores and absorbing molecules are included. (c) 2013 Optical Society of America. C1 [Hill, Steven C.; Pan, Yong-Le; Williamson, Chatt] US Army Res Lab, Adelphi, MD 20783 USA. [Santarpia, Joshua L.] Sandia Natl Labs, Albuquerque, NM USA. [Hill, Hanna H.] Univ Maryland, College Pk, MD 20742 USA. RP Hill, SC (reprint author), US Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM steven.c.hill32.civ@mail.mil FU Defense Threat and Reduction Agency (DTRA) Basic and Supporting Science Program; US Army Research Laboratory mission funds FX Supported by the Defense Threat and Reduction Agency (DTRA) Basic and Supporting Science Program and US Army Research Laboratory mission funds. NR 138 TC 14 Z9 14 U1 4 U2 31 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1094-4087 J9 OPT EXPRESS JI Opt. Express PD SEP 23 PY 2013 VL 21 IS 19 BP 22285 EP 22313 DI 10.1364/OE.21.022285 PG 29 WC Optics SC Optics GA 233DY UT WOS:000325547200055 PM 24104120 ER PT J AU Jian, WW Cheng, GM Xu, WZ Koch, CC Wang, QD Zhu, YT Mathaudhu, SN AF Jian, W. W. Cheng, G. M. Xu, W. Z. Koch, C. C. Wang, Q. D. Zhu, Y. T. Mathaudhu, S. N. TI Physics and model of strengthening by parallel stacking faults SO APPLIED PHYSICS LETTERS LA English DT Article ID HALL-PETCH BREAKDOWN; NANOCRYSTALLINE MATERIALS; GRAIN-SIZE; MECHANICAL-PROPERTIES; PLASTIC-DEFORMATION; STRAIN-RATE; ALLOYS; MAGNESIUM; ENERGY; COPPER AB We have recently reported that parallel stacking faults (SFs) can tremendously increase the strength of a magnesium alloy. The strengthening is found to increase linearly with the reciprocal of the mean SF spacing, d. In this study we analyze dislocation interactions with SFs, and then propose a physics-based model to explain the observed relationship between yield strength and SFs spacing. Similar to the empirical Hall-Petch relationship for grain size, it is expected that this strengthening mechanism will hold true for a variety of materials engineered with parallel spaced stacking faults over a wide range of fault spacing. (C) 2013 AIP Publishing LLC. C1 [Jian, W. W.; Cheng, G. M.; Xu, W. Z.; Koch, C. C.; Zhu, Y. T.; Mathaudhu, S. N.] N Carolina State Univ, Dept Mat Sci & Engn, Raleigh, NC 27695 USA. [Wang, Q. D.] Shanghai Jiao Tong Univ, Sch Mat Sci & Engn, Shanghai 200030, Peoples R China. [Mathaudhu, S. N.] US Army, Div Mat Sci, Res Off, Res Triangle Pk, NC 27709 USA. RP Koch, CC (reprint author), N Carolina State Univ, Dept Mat Sci & Engn, Box 7907, Raleigh, NC 27695 USA. EM carl_koch@ncsu.edu; wangqudong@sjtu.edu.cn; ytzhu@ncsu.edu; suveen.n.mathaudhu.civ@mail.mil RI Zhu, Yuntian/B-3021-2008; Xu, Weizong/G-3328-2014; Cheng, Guangming/F-8999-2010; Mathaudhu, Suveen/B-4192-2009; Wang, Qudong/E-3410-2016 OI Zhu, Yuntian/0000-0002-5961-7422; Xu, Weizong/0000-0003-0030-8606; Cheng, Guangming/0000-0001-5852-1341; Wang, Qudong/0000-0002-4600-8476 FU U.S. Army Research Office [W911NF-12-1-0009]; National Natural Science Foundation of China [51074106] FX This work was supported by the U.S. Army Research Office under Grant No. W911NF-12-1-0009. Q.D.W. was supported by the National Natural Science Foundation of China under Grant No. 51074106. NR 44 TC 18 Z9 18 U1 3 U2 34 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD SEP 23 PY 2013 VL 103 IS 13 AR 133108 DI 10.1063/1.4822323 PG 4 WC Physics, Applied SC Physics GA 229RJ UT WOS:000325284500078 ER PT J AU Breaud, AR Henemyre-Harris, CL Schools, S Emezienna, N Clarke, W AF Breaud, Autumn R. Henemyre-Harris, Claudia L. Schools, Sabitha Emezienna, Nkechinyere Clarke, William TI Rapid quantification of the aminoglycoside arbekacin in serum using high performance liquid chromatography-tandem mass spectrometry (vol 418C, pg 102, 2013) SO CLINICA CHIMICA ACTA LA English DT Correction C1 [Breaud, Autumn R.; Henemyre-Harris, Claudia L.; Schools, Sabitha; Emezienna, Nkechinyere; Clarke, William] Johns Hopkins Sch Med, Dept Pathol, Baltimore, MD USA. [Henemyre-Harris, Claudia L.] US Army Med Dept Ctr & Sch, Ft Sam Houston, TX USA. RP Clarke, W (reprint author), 1800 Orleans St,Zayed Tower B1020F, Baltimore, MD 21287 USA. EM wclarke@jhmi.edu NR 1 TC 0 Z9 0 U1 1 U2 5 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0009-8981 J9 CLIN CHIM ACTA JI Clin. Chim. Acta PD SEP 23 PY 2013 VL 424 BP 298 EP 298 DI 10.1016/j.cca.2013.03.006 PG 1 WC Medical Laboratory Technology SC Medical Laboratory Technology GA 226NH UT WOS:000325042600053 ER PT J AU Seder, RA Chang, LJ Enama, ME Zephir, KL Sarwar, UN Gordon, IJ Holman, LA James, ER Billingsley, PF Gunasekera, A Richman, A Chakravarty, S Manoj, A Velmurugan, S Li, ML Ruben, AJ Li, T Eappen, AG Stafford, RE Plummer, SH Hendel, CS Novik, L Costner, PJM Mendoza, FH Saunders, JG Nason, MC Richardson, JH Murphy, J Davidson, SA Richie, TL Sedegah, M Sutamihardja, A Fahle, GA Lyke, KE Laurens, MB Roederer, M Tewari, K Epstein, JE Sim, BKL Ledgerwood, JE Graham, BS Hoffman, SL AF Seder, Robert A. Chang, Lee-Jah Enama, Mary E. Zephir, Kathryn L. Sarwar, Uzma N. Gordon, Ingelise J. Holman, LaSonji A. James, Eric R. Billingsley, Peter F. Gunasekera, Anusha Richman, Adam Chakravarty, Sumana Manoj, Anita Velmurugan, Soundarapandian Li, MingLin Ruben, Adam J. Li, Tao Eappen, Abraham G. Stafford, Richard E. Plummer, Sarah H. Hendel, Cynthia S. Novik, Laura Costner, Pamela J. M. Mendoza, Floreliz H. Saunders, Jamie G. Nason, Martha C. Richardson, Jason H. Murphy, Jittawadee Davidson, Silas A. Richie, Thomas L. Sedegah, Martha Sutamihardja, Awalludin Fahle, Gary A. Lyke, Kirsten E. Laurens, Matthew B. Roederer, Mario Tewari, Kavita Epstein, Judith E. Sim, B. Kim Lee Ledgerwood, Julie E. Graham, Barney S. Hoffman, Stephen L. CA VRC 312 Study Team TI Protection Against Malaria by Intravenous Immunization with a Nonreplicating Sporozoite Vaccine SO SCIENCE LA English DT Article ID PLASMODIUM-FALCIPARUM MALARIA; CIRCUMSPOROZOITE PROTEIN VACCINE; CD8+ T-CELLS; LIVER STAGES; IMMUNITY; MICE; ANTIBODIES; EFFICACY; TRIAL AB Consistent, high-level, vaccine-induced protection against human malaria has only been achieved by inoculation of Plasmodium falciparum (Pf) sporozoites (SPZ) by mosquito bites. We report that the PfSPZ Vaccine-composed of attenuated, aseptic, purified, cryopreserved PfSPZ-was safe and well tolerated when administered four to six times intravenously (IV) to 40 adults. Zero of six subjects receiving five doses and three of nine subjects receiving four doses of 1.35 x 10(5) PfSPZ Vaccine and five of six nonvaccinated controls developed malaria after controlled human malaria infection (P = 0.015 in the five-dose group and P = 0.028 for overall, both versus controls). PfSPZ-specific antibody and T cell responses were dose-dependent. These data indicate that there is a dose-dependent immunological threshold for establishing high-level protection against malaria that can be achieved with IV administration of a vaccine that is safe and meets regulatory standards. C1 [Seder, Robert A.; Chang, Lee-Jah; Enama, Mary E.; Zephir, Kathryn L.; Sarwar, Uzma N.; Gordon, Ingelise J.; Holman, LaSonji A.; Plummer, Sarah H.; Hendel, Cynthia S.; Novik, Laura; Costner, Pamela J. M.; Mendoza, Floreliz H.; Saunders, Jamie G.; Roederer, Mario; Tewari, Kavita; Ledgerwood, Julie E.; Graham, Barney S.] NIAID, VRC, NIH, Rockville, MD 20852 USA. [James, Eric R.; Billingsley, Peter F.; Gunasekera, Anusha; Richman, Adam; Chakravarty, Sumana; Manoj, Anita; Velmurugan, Soundarapandian; Ruben, Adam J.; Li, Tao; Eappen, Abraham G.; Stafford, Richard E.; Sim, B. Kim Lee; Hoffman, Stephen L.] Sanaria, Rockville, MD 20850 USA. [Li, MingLin; Stafford, Richard E.; Sim, B. Kim Lee; Hoffman, Stephen L.] Prot Potential, Rockville, MD 20850 USA. [Nason, Martha C.] NIAID, Biostat Res Branch, Div Clin Res, NIH, Rockville, MD 20852 USA. [Richardson, Jason H.; Murphy, Jittawadee; Davidson, Silas A.] Walter Reed Army Inst Res, Entomol Branch, Silver Spring, MD 20910 USA. [Richie, Thomas L.; Sedegah, Martha; Sutamihardja, Awalludin; Epstein, Judith E.] Naval Med Res Ctr, US Mil Malaria Vaccine Program, Silver Spring, MD 20910 USA. [Fahle, Gary A.] NIH, Dept Lab Med, Bethesda, MD 20892 USA. [Lyke, Kirsten E.; Laurens, Matthew B.] Univ Maryland, Sch Med, Ctr Vaccine Dev, Baltimore, MD 21201 USA. [Laurens, Matthew B.] Howard Hughes Med Inst, Baltimore, MD 21201 USA. RP Seder, RA (reprint author), NIAID, VRC, NIH, Rockville, MD 20852 USA. EM rseder@mail.nih.gov RI Laurens, Matthew/E-7293-2013; OI Laurens, Matthew/0000-0003-3874-581X; Richie, Thomas/0000-0002-2946-5456 FU National Institute of Allergy and Infectious Diseases (NIAID) [4R44AI055229-08, 3R44AI055229-06S1, 5R44AI058499-05, N01-AI-40096]; Howard Hughes Medical Institute; [6000.RADI.F.A0309] FX The data presented in this manuscript are tabulated in the main figures and the supplementary materials. The clinical trial was funded and supported by the National Institute of Allergy and Infectious Diseases (NIAID) Intramural Research Program. Production and characterization of the vaccine were supported in part by NIAID Small Business Innovation Research grants 4R44AI055229-08, 3R44AI055229-06S1, and 5R44AI058499-05. Preclinical toxicology and biodistribution studies were supported in part by NIAID preclinical service contract N01-AI-40096. Molecular diagnosis was supported by the Howard Hughes Medical Institute. A materials transfer agreement will be required for the use of recombinant PfMSP-1 and PfEBA-175, HC-04 cells, and 2A10 monoclonal antibody. A number of patents on PfSPZ have been issued, allowed, or filed in the United States and internationally. The U.S. patents include S. L. Hoffman et al., U.S. Patent 7,229,627 (2007) (there is a divisional of this patent with claims directed to aseptic adult Anopheles-species mosquitoes and aseptic Plasmodium-species sporozoites, USSN 11/726,622); S. L. Hoffman et al., U.S. Patent Pub. US2005/0208078 (2005); and B. K. L. Sim, S. L. Hoffman, M. Li, R. E. Stafford, U.S. Patent Pub U.S. 2010/0183680 (2010). There is also a patent on HC-04 cells [J. Prachumsri et al., U.S. Patent 7015036 (2006)]. The findings and conclusions in this report are those of the authors and do not necessarily reflect the views of the funding agency or collaborators. The views expressed in this article are those of the author and do not necessarily reflect the official policy or position of the Department of the Navy, Department of the Army, Department of Defense, or the U.S. government. This work was supported by work unit number 6000.RADI.F.A0309. The study protocol was approved by the Naval Medical Research Center Institutional Review Board in compliance with all applicable federal regulations governing the protection of human subjects. J.E.E., T.L.R., J.H.R., J.M., and S.A.D. are military service members. This work was prepared as part of their official duties. Title 17 U.S.C. 101 defines a US. government work as a work prepared by a military service member or employee of the U.S. government as part of that person's official duties. The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting true views of the Departments of the Army, Navy, or Defense. The authors thank the vaccine trial participants for their contribution and commitment to vaccine research. We acknowledge the contributions of our NIH Clinical Center and NIAID colleagues, especially A. S. Fauci for thoughtful advice and review of the manuscript; J. Stein, J. Pierson, R. Eckes, P. Driscoll, L. Ediger, and the nursing staff of the 5NW, SCSU, 5SE-S, and 5SE-N units; our VRC colleagues, especially B. Flynn, A. Mittelman, M. Young, C. Artis, R. Hicks, and T. Abram; the EMMES Corporation; R. Thompson, F. Beams, M. Garley, A. Hoffman, and D. Dolberg of Sanaria for administrative, operations, and legal support and T. Luke for insight and inspiration; the NIAID Institutional Review Board; the NIAID Office of Communications and Government Relations; the NIH Clinical Center Investigational New Drug Pharmacy; and the NIH Clinical Center Patient Recruitment and Public Liaison Office. We appreciate the expert reviews of the Safety Monitoring Committee (A. Durbin, K. Kester, and A. Cross) and the assistance from the U.S.; Military Malaria Vaccine Program, the Walter Reed Army Institute of Research Entomology Branch, and the Naval Medical Research Center, especially A. Reyes, Y. Alcorta, G. Banania, C. Fedders, M. Dowler, T. Savransky, D. Patel, C. Brando, and K. Kobylinski. NR 36 TC 229 Z9 231 U1 8 U2 89 PU AMER ASSOC ADVANCEMENT SCIENCE PI WASHINGTON PA 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 USA SN 0036-8075 J9 SCIENCE JI Science PD SEP 20 PY 2013 VL 341 IS 6152 BP 1359 EP 1365 DI 10.1126/science.1241800 PG 7 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 220PK UT WOS:000324597200037 PM 23929949 ER PT J AU Cabalo, J Sausa, R AF Cabalo, J. Sausa, R. TI Theoretical and Experimental Study of the C-H Stretching Overtones of 2,4,6,8,10,12-hexanitro-2,4,6,8,10,12 hexaazaisowurtzitane (CL20) SO JOURNAL OF PHYSICAL CHEMISTRY A LA English DT Article ID ENERGETIC MATERIALS; SPECTRA; CRYSTAL; CL-20; SPECTROSCOPY; MOLECULES; HYDROGEN; DENSITY; DFT AB An understanding of how molecular environment and structure are reflected in optical absorption spectra offers a number of advantages, such as improved detection of materials or providing an easy means of distinguishing crystal polymorphs of the same molecular solid. This study advances this understanding by comparing near IR laser photoacoustic absorption measurements of the first C-H stretch overtones around 5975 cm(-1) of beta-2,4,6,8,10,12-hexanitro-2,4,6,8,10,12-hexaazaisowurtzitane (CL20) to simulated spectra using density functional calculations and the local mode model of C-H stretches. The calculations reveal that accounting for movement of charge throughout the model crystal unit cell with a pure quantum mechanical method in the calculation of the transition dipole moment is critical to matching the experimental data. Vibrational modes in a given molecule induce movement of charge in neighboring molecules, such that calculation of the transition dipole moment had to include the entire crystal unit cell. Movement of charge across the periodic boundary conditions (PBC) of the model needs to be accounted for to calculate a spectrum validated by the experimental measurement. The Hirshfeld population analysis minimizes discontinuities for movement of charge across the PBC. C1 [Cabalo, J.] Edgewood Chem Biol Ctr, RDCB DRI I, Aberdeen Proving Ground, MD 21010 USA. [Sausa, R.] US Army Res Lab, RDRL WML B, Aberdeen Proving Ground, MD 21005 USA. RP Cabalo, J (reprint author), Edgewood Chem Biol Ctr, RDCB DRI I, 5183 Blackhawk Rd, Aberdeen Proving Ground, MD 21010 USA. FU ARL; ECBC In-house Laboratory Independent Research Program FX We thank Dr. Rose Pesce-Rodriguez of the U. S. Army Research Laboratory for providing us with the CL20 sample and the use of her photoacoustic cell. We also thank the ARL DoD Supercomputing Resource Center for providing access to high performance computing resources. Support from both the ARL and the ECBC In-house Laboratory Independent Research Program administered by Dr. A. W. Fountain is greatly appreciated. NR 23 TC 2 Z9 2 U1 1 U2 16 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1089-5639 J9 J PHYS CHEM A JI J. Phys. Chem. A PD SEP 19 PY 2013 VL 117 IS 37 BP 9039 EP 9046 DI 10.1021/jp403778a PG 8 WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical SC Chemistry; Physics GA 287YT UT WOS:000329579200006 PM 23957608 ER EF