FN Thomson Reuters Web of Science™ VR 1.0 PT S AU Ferrett, T Valenti, MC Torrieri, D AF Ferrett, Terry Valenti, Matthew C. Torrieri, Don GP IEEE TI An Iterative Noncoherent Relay Receiver for the Two-way Relay Channel SO 2013 IEEE INTERNATIONAL CONFERENCE ON COMMUNICATIONS (ICC) SE IEEE International Conference on Communications LA English DT Proceedings Paper CT IEEE International Conference on Communications (ICC) CY JUN 09-13, 2013 CL Budapest, HUNGARY SP IEEE AB Digital network coding improves the throughput of the two-way relay channel by allowing multiple sources to transmit simultaneously to the relay. This work considers the development of a relay receiver applying a specific modulation and channel coding technique - turbo-coded noncoherent orthogonal FSK in the two-way relay channel operated with digital network coding. The relay receiver supports any modulation order which is a power of two, and iterative channel decoding with information feedback from decoder to demodulator, using bit interleaved coded modulation with iterative decoding (BICM-ID). The performance of the receiver is investigated in fading channels through error-rate simulations and capacity analysis, and results show an energy efficiency improvement of 0.5-0.9 dB over similar systems which do not utilize BICM-ID. C1 [Ferrett, Terry; Valenti, Matthew C.] West Virginia Univ, Morgantown, WV 26506 USA. [Torrieri, Don] US Army Res Lab, Adelphi, MD USA. RP Ferrett, T (reprint author), West Virginia Univ, Morgantown, WV 26506 USA. OI Valenti, Matthew/0000-0001-6089-0509 NR 12 TC 3 Z9 3 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 1550-3607 BN 978-1-4673-3122-7 J9 IEEE ICC PY 2013 BP 5903 EP + PG 2 WC Telecommunications SC Telecommunications GA BC0WB UT WOS:000349673806092 ER PT S AU Cheng, M Ye, QM Erbacher, RF AF Cheng, Maggie Ye, Quanmin Erbacher, Robert F. GP IEEE TI Characterization and Visualization of Sophisticated Scanning Attacks SO 2013 IEEE INTERNATIONAL CONFERENCE ON COMMUNICATIONS (ICC) SE IEEE International Conference on Communications LA English DT Proceedings Paper CT IEEE International Conference on Communications (ICC) CY JUN 09-13, 2013 CL Budapest, HUNGARY SP IEEE AB Detection of sophisticated stealthy network scans requires analyzing large amounts of network data collected over long periods of time. The sheer volume of the data prohibits efficient detection from a pure algorithmic approach. However timely detection of such sophisticated scanning attacks is critical since the attacker employing these approaches is usually well-resourced and potentially can bring high impact to the network than a naive attacker can. To detect such sophisticated scans we propose the integration of algorithmic detection and visualization for human detection to simultaneously optimize computational complexity and human analyst time. The proposed approach provides real world detection capabilities without excessive computation overhead. We characterize the features of scanning attacks in a graph theory context, propose efficient graph algorithms to extract these features in real time, employ visualization techniques to show the relevant multidimensional characteristics, and provide test scenarios to show that the proposed work is more efficient and effective than previous approaches. C1 [Cheng, Maggie; Ye, Quanmin] Missouri Univ Sci & Technol, Rolla, MO 65401 USA. [Erbacher, Robert F.] Army Res Lab, Adelphi, MD USA. RP Cheng, M (reprint author), Missouri Univ Sci & Technol, Rolla, MO 65401 USA. EM chengm@mst.edu; qy4y4@mst.edu; robert.f.erbacher.civ@mail.mil NR 7 TC 0 Z9 0 U1 1 U2 1 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 1550-3607 BN 978-1-4673-3122-7 J9 IEEE ICC PY 2013 PG 5 WC Telecommunications SC Telecommunications GA BC0WB UT WOS:000349673801027 ER PT S AU Liu, KQ Zhao, Q Swami, A AF Liu, Keqin Zhao, Qing Swami, Ananthram GP IEEE TI Dynamic Probing for Intrusion Detection under Resource Constraints SO 2013 IEEE INTERNATIONAL CONFERENCE ON COMMUNICATIONS (ICC) SE IEEE International Conference on Communications LA English DT Proceedings Paper CT IEEE International Conference on Communications (ICC) CY JUN 09-13, 2013 CL Budapest, HUNGARY SP IEEE DE Intrusion detection; dynamic probing; non-stochastic multi-armed bandit; regret AB We consider a large-scale cyber network with N components. Each component is either in a healthy state or an abnormal state. To model scenarios where attacks to the network may not follow a stochastic process and the attackers may adapt to the actions of the intrusion detection system (IDS) in an arbitrary and unknown way, we adopt a non-stochastic model in which the attack process at each component can be any unknown deterministic sequence. Due to resource constraints, the IDS can only choose K (K < N) components to probe at each time. An abnormal component incurs a cost per unit time (depending on the criticality of the component) until it is probed and fixed. The objective is a dynamic probing strategy under the performance measure of regret, defined as the performance loss compared to that of a genie who knows the entire attack processes a priori and probes optimally (under certain constraints) based on this knowledge. We propose a policy that achieves sublinear regret order, thus offers the same time averaged performance as that of the omniscient genie. C1 [Liu, Keqin; Zhao, Qing] Univ Calif Davis, Dept Elect & Comp Engn, Davis, CA 95616 USA. [Swami, Ananthram] US Army, Res Lab, Adelphi, MD 20783 USA. RP Liu, KQ (reprint author), Univ Calif Davis, Dept Elect & Comp Engn, Davis, CA 95616 USA. EM kqliu@ucdavis.edu; qzhao@ucdavis.edu; ananthram.swami@us.army.mil FU Army Research Lab [W911NF1120086] FX This work was supported by Army Research Lab under Grant W911NF1120086. NR 14 TC 0 Z9 0 U1 0 U2 1 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 1550-3607 BN 978-1-4673-3122-7 J9 IEEE ICC PY 2013 PG 5 WC Telecommunications SC Telecommunications GA BC0WB UT WOS:000349673801014 ER PT S AU Subramanian, V Uluagac, S Cam, H Beyah, R AF Subramanian, Venkatachalam Uluagac, Selcuk Cam, Hasan Beyah, Raheem GP IEEE TI Examining the Characteristics and Implications of Sensor Side Channels SO 2013 IEEE INTERNATIONAL CONFERENCE ON COMMUNICATIONS (ICC) SE IEEE International Conference on Communications LA English DT Proceedings Paper CT IEEE International Conference on Communications (ICC) CY JUN 09-13, 2013 CL Budapest, HUNGARY SP IEEE DE Wireless Sensor Networks; Side Channels; Out-of-Band; Proximity Attacks AB The nodes in wireless sensor networks (WSNs) utilize the radio frequency (RF) channel to communicate. Given that the RF channel is the primary communication channel, many researchers have developed techniques for securing that channel. However, the RF channel is not the only interface into a sensor. The sensing components, which are primarily designed to sense characteristics about the outside world, can also be used (or misused) as a communication (side) channel. In this paper, we characterize the side channels for various sensory components (i.e., light sensor, acoustic sensor, and accelerometer). While previous work has focused on the use of these side channels to improve the security and performance of a WSN, we seek to determine if the side channels have enough capacity to potentially be used for malicious activity. Specifically, we evaluate the feasibility and practicality of the side channels using today's sensor technology and illustrate that these channels have enough capacity to enable the transfer of common, well-known malware. The ultimate goal of this work is to illustrate the need for intrusion detection systems (IDSs) that not only monitor the RF channel, but also monitor the values returned by the sensory components. C1 [Subramanian, Venkatachalam; Uluagac, Selcuk; Beyah, Raheem] Georgia Inst Technol, Sch ECE, GT CAP, Atlanta, GA 30332 USA. [Cam, Hasan] U S Army Res Lab, Network Sci Div, Adelphi, MD 20783 USA. RP Subramanian, V (reprint author), Georgia Inst Technol, Sch ECE, GT CAP, Atlanta, GA 30332 USA. EM venkat.subbu@gatech.edu; selcuk@ece.gatech.edu; hasan.cam.civ@mail.mil; rbeyah@ece.gatech.edu FU NSF [CNS-1052769] FX This work was partly supported by NSF Grant No. CNS-1052769 NR 13 TC 0 Z9 0 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 1550-3607 BN 978-1-4673-3122-7 J9 IEEE ICC PY 2013 PG 6 WC Telecommunications SC Telecommunications GA BC0WB UT WOS:000349673801055 ER PT S AU Wang, ZW Yang, JC Nasrabadi, N Huang, T AF Wang, Zhaowen Yang, Jianchao Nasrabadi, Nasser Huang, Thomas GP IEEE TI A Max-Margin Perspective on Sparse Representation-based Classification SO 2013 IEEE INTERNATIONAL CONFERENCE ON COMPUTER VISION (ICCV) SE IEEE International Conference on Computer Vision LA English DT Proceedings Paper CT IEEE International Conference on Computer Vision (ICCV) CY DEC 01-08, 2013 CL Sydney, AUSTRALIA SP IEEE, CVF, IEEE Comp Soc, APRS, Australiasn Natl Univ, NICTA, FACE++, Natl Robot Engn Ctr, Google, Disney Res, nVIDIA, Raytheon BBN Technologies, Facebook, Adobe, Kitware, OMRON, SRI Int ID FACE RECOGNITION; K-SVD AB Sparse Representation-based Classification (SRC) is a powerful tool in distinguishing signal categories which lie on different subspaces. Despite its wide application to visual recognition tasks, current understanding of SRC is solely based on a reconstructive perspective, which neither offers any guarantee on its classification performance nor provides any insight on how to design a discriminative dictionary for SRC. In this paper, we present a novel perspective towards SRC and interpret it as a margin classifier. The decision boundary and margin of SRC are analyzed in local regions where the support of sparse code is stable. Based on the derived margin, we propose a hinge loss function as the gauge for the classification performance of SRC. A stochastic gradient descent algorithm is implemented to maximize the margin of SRC and obtain more discriminative dictionaries. Experiments validate the effectiveness of the proposed approach in predicting classification performance and improving dictionary quality over reconstructive ones. Classification results competitive with other state-of-the-art sparse coding methods are reported on several data sets. C1 [Wang, Zhaowen; Huang, Thomas] Univ Illinois, Beckman Inst, Urbana, IL 61801 USA. [Yang, Jianchao] Adobe Syst Inc, San Jose, CA 95110 USA. [Nasrabadi, Nasser] US Army Res Lab, Adelphi, MD 20783 USA. RP Wang, ZW (reprint author), Univ Illinois, Beckman Inst, Urbana, IL 61801 USA. EM wang308@ifp.uiuc.edu; jiayang@adobe.com; nasser.m.nasrabadi.civ@mail.mil; huang@ifp.uiuc.edu NR 29 TC 9 Z9 9 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 1550-5499 BN 978-1-4799-2839-2 J9 IEEE I CONF COMP VIS PY 2013 BP 1217 EP 1224 DI 10.1109/ICCV.2013.154 PG 8 WC Computer Science, Artificial Intelligence SC Computer Science GA BC3PE UT WOS:000351830500152 ER PT S AU Yao, JT Abreu, MR Chakravarty, S AF Yao, Jingting Abreu, Matthew R. Chakravarty, Sumit GP IEEE TI A Combination Based Control Selection Strategy for Ultrasonic Motor SO 2013 IEEE INTERNATIONAL CONFERENCE ON CONTROL APPLICATIONS (CCA) SE IEEE International Conference on Control Applications LA English DT Proceedings Paper CT IEEE International Conference on Control Applications (CCA) CY AUG 28-30, 2013 CL Hyderabad, INDIA SP IEEE ID ROTARY AB Ultrasonic motors (USM) are a new type of high precision positioning drive system. They provide significant advantages compared to traditional electromagnetic motors like fast control, high torque, low electromagnetic interference and light weight. It is however difficult to formulate exact mathematical model of the ultrasonic motor due to complex nonlinearities involved as a result of its use of friction and inverse piezoelectric phenomena as its driving mechanism. These nonlinearities pose significant problem for precise position control of the motor. Previous research have therefore suggested developing control design using elaborate nonlinear control schemes like Sliding Mode Control (SMC) used in tandem with advanced machine learning algorithms like genetic algorithms. The drawback of implementing these approaches is the computational cost and complexity involved. In this paper we present a new schema for control of USM. We divide the problem into two complementary parts, namely estimation of the motors parameters and controller design based on the estimator result. Depending on the precision requirement of the application the estimation process can be made nonlinear and / or time varying. Similarly based on the affordable computational complexity, we can choose a linear or a nonlinear controller. Results of experiments conducted show the comparative performance of these different categories. Guidelines are suggested for suitable combination of them depending upon a user's requirement. C1 [Yao, Jingting; Chakravarty, Sumit] NYIT, Nanjing Campus, Nanjing 210046, NJ, Peoples R China. [Yao, Jingting] Nanjing Univ Posts & Telecommun, Nanjing 210046, NJ, Peoples R China. [Abreu, Matthew R.] US Mil Acad, West Point, NY 10996 USA. RP Yao, JT (reprint author), NYIT, Nanjing Campus, Nanjing 210046, NJ, Peoples R China. EM jingtingyao@yahoo.com; Matthew.Abreu@usma.edu; schakrav@nyit.edu NR 12 TC 0 Z9 0 U1 1 U2 1 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 1085-1992 BN 978-1-4799-1559-0 J9 IEEE INTL CONF CONTR PY 2013 BP 826 EP 831 PG 6 WC Automation & Control Systems; Computer Science, Interdisciplinary Applications; Engineering, Electrical & Electronic SC Automation & Control Systems; Computer Science; Engineering GA BE2OS UT WOS:000369733600109 ER PT S AU Wang, ZW Yang, JC Nasrabadi, N Wang, JP Huang, T AF Wang, Zhaowen Yang, Jianchao Nasrabadi, Nasser Wang, Jiangping Huang, Thomas GP IEEE TI OPPORTUNISTIC SENSING FOR OBJECT RECOGNITION - A UNIFIED FORMULATION FOR DYNAMIC SENSOR SELECTION AND FEATURE EXTRACTION SO 2013 IEEE INTERNATIONAL CONFERENCE ON MULTIMEDIA AND EXPO (ICME 2013) SE IEEE International Conference on Multimedia and Expo LA English DT Proceedings Paper CT IEEE International Conference on Multimedia and Expo Workshops (ICMEW) CY JUL 15-19, 2013 CL San Jose, CA SP IEEE DE opportunistic sensing; view selection; feature extraction; objection recognition ID INFORMATION AB A novel problem of object recognition with dynamically allocated sensing resources is considered in this paper. We call this problem opportunistic sensing since prior knowledge about the correlation between class label and signal distribution is exploited as early as in data acquisition. Two forms of sensing parameters - discrete sensor index and continuous linear measurement vector - are optimized within the same maximum negative entropy framework. The computationally intractable expected entropy is approximated using unscented transform for Gaussian models, and we solve the problem using a gradient-based method. Our formulation is theoretically shown to be closely related to the maximum mutual information criterion for sensor selection and linear feature extraction techniques such as PCA, LDA, and CCA. The proposed approach is validated on multi-view vehicle classification and face recognition datasets, and remarkable improvement over baseline methods is demonstrated in the experiments. C1 [Wang, Zhaowen; Wang, Jiangping; Huang, Thomas] Univ Illinois, Beckman Inst, Urbana, IL 61801 USA. [Yang, Jianchao] Adobe Syst Inc, San Jose, CA 95110 USA. [Nasrabadi, Nasser] U.S. Army Res Lab, Adelphi, MD 20783 USA. RP Wang, ZW (reprint author), Univ Illinois, Beckman Inst, Urbana, IL 61801 USA. EM wang308@ifo.uiuc.edu; jwang63@ifp.uiuc.edu; nasser.m.nasrabadi.civ@mail.mil; jiayang@adobe.com; huang@ifp.uiuc.edu FU U.S. Army Research Laboratory; U.S. Army Research Office [W911NF-09-1-0383] FX This work is supported by the U.S. Army Research Laboratory and U.S. Army Research Office under grant number W911NF-09-1-0383 NR 12 TC 0 Z9 0 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 1945-7871 BN 978-1-4799-0015-2 J9 IEEE INT CON MULTI PY 2013 PG 6 WC Computer Science, Software Engineering; Computer Science, Theory & Methods; Engineering, Electrical & Electronic SC Computer Science; Engineering GA BB8FR UT WOS:000346507500056 ER PT S AU Chbili, Z Cheung, KP Campbell, JP Suehle, JS Ioannou, DE Ryu, SH Lelis, AJ AF Chbili, Z. Cheung, K. P. Campbell, J. P. Suehle, J. S. Ioannou, D. E. Ryu, S. -H. Lelis, A. J. GP IEEE TI Unusual Bias Temperature Instability in SiC DMOSFET SO 2013 IEEE INTERNATIONAL INTEGRATED RELIABILITY WORKSHOP FINAL REPORT (IRW) SE IEEE International Integrated Reliability Workshop Final Report LA English DT Proceedings Paper CT IEEE International Integrated Reliability Workshop (IIRW) CY OCT 13-17, 2013 CL South Lake Tahoe, CA SP IEEE, IEEE Electron Devices Soc, IEEE Reliabil Soc DE SiC; DMOSFET; BTI AB We observe an unusual instability in the SiC DMOSFET transistor characteristics. From a series of bias conditions at elevated temperatures, we conclude that a high density of hole traps in the oxide near the SiO2/SiC interface are responsible. C1 [Chbili, Z.; Cheung, K. P.; Campbell, J. P.; Suehle, J. S.] NIST, Semicond & Dimens Metrol Div, Gaithersburg, MD 20899 USA. [Chbili, Z.; Ioannou, D. E.] George Mason Univ, Fairfax, VA 22030 USA. [Ryu, S. -H.] Cree Inc, SiC Power Device, Durham, NC 27703 USA. [Lelis, A. J.] Army Res Lab, Adelphi, MD 20783 USA. RP Chbili, Z (reprint author), NIST, Semicond & Dimens Metrol Div, 100 Bur Dr, Gaithersburg, MD 20899 USA. EM kpckpc@ieee.org NR 8 TC 3 Z9 3 U1 1 U2 2 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 1930-8841 BN 978-1-4799-0350-4 J9 INT INTEG REL WRKSP PY 2013 BP 90 EP 93 PG 4 WC Engineering, Electrical & Electronic SC Engineering GA BC7OC UT WOS:000355093800032 ER PT S AU Ezzeddine, A Hung, A Viveiros, E Huang, HC AF Ezzeddine, Amin Hung, Alfred Viveiros, Ed Huang, Ho-Chung GP IEEE TI Ultra Wide-Band, High-Power, High-Efficiency GaN Amplifier SO 2013 IEEE INTERNATIONAL WIRELESS SYMPOSIUM (IWS) SE International Conference on Computer Systems and Applications LA English DT Proceedings Paper CT IEEE International Wireless Symposium (IWS) CY APR 14-18, 2013 CL Beijing, PEOPLES R CHINA SP IEEE DE Broadband amplifiers; high-voltage techniques; microwave devices; power combiners; MMICs AB We report a high-performance GaN amplifier operating from 100MHz to 3,000MHz. The best results included 100W output power, 22dB gain with 40% power-added-efficiency from 100MHz to 3,000MHz. This performance is achieved by tailoring both the device impedance and by using unique wide-band circuit matching topology. Detailed design technique of both device and matching circuit will be presented. C1 [Ezzeddine, Amin; Huang, Ho-Chung] AMCOM Commun Inc, 401 Profess Dr, Gaithersburg, MD 20879 USA. [Hung, Alfred; Viveiros, Ed] US Army Res Lab, Adelphi, MD USA. RP Ezzeddine, A (reprint author), AMCOM Commun Inc, 401 Profess Dr, Gaithersburg, MD 20879 USA. EM amin@amcomusa.com; hohuang@amcomusa.com NR 6 TC 0 Z9 0 U1 1 U2 1 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 2161-5322 BN 978-1-4673-2140-2 J9 I C COMP SYST APPLIC PY 2013 PG 4 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA BE5OU UT WOS:000373165300045 ER PT S AU Yang, Y Li, S Maxwell, AS Barker, ND Peng, Y Li, Y Li, HN Wu, X Li, P Huang, T Zhang, CH Wang, N Perkins, EJ Zhang, CY Gong, P AF Yang, Yi Li, Si Maxwell, Andrew S. Barker, Natalie D. Peng, Yan Li, Ying Li, Haoni Wu, Xi Li, Peng Huang, Tao Zhang, Chenhua Wang, Nan Perkins, Edward J. Zhang, Chaoyang Gong, Ping GP IEEE TI DECIPHERING CHEMICALLY-INDUCED REVERSIBLE NEUROTOXICITY BY RECONSTRUCTING PERTURBED PATHWAYS FROM TIME SERIES MICROARRAY GENE EXPRESSION DATA SO 2013 IEEE INTERNATIONAL WORKSHOP ON GENOMIC SIGNAL PROCESSING AND STATISTICS (GENSIPS 2013) SE IEEE International Workshop on Genomic Signal Processing and Statistics LA English DT Proceedings Paper CT IEEE International Workshop on Genomic Signal Processing and Statistics (GENSIPS) CY NOV 17-19, 2013 CL Houston, TX SP Inst Elect & Elect Engineers, IEEE Signal Proc Soc DE differential gene interaction network; time course gene expression dataset; reversible neurotoxicity; KEGG pathway; earthworm ID REGULATORY NETWORKS AB The etiology of chemically-induced neurotoxicity like seizures is poorly understood. Using reversible neurotoxicity induced by two neurotoxicants as example, we demonstrate that a bioinformatics-guided reverse engineering approach can be applied to analyze time series microarray gene expression data and uncover the underlying molecular mechanism. Our results reinforce previous findings that cholinergic and GABAergic synapse pathways are the target of carbaryl and RDX, respectively. We also conclude that perturbations to these pathways by sublethal concentrations of RDX and carbaryl were temporary, and earthworms were capable of fully recovering at the end of the 7-day recovery phase. In addition, our study indicates that many pathways other than those related to synaptic and neuronal activities were altered during the 6-day exposure phase. C1 [Yang, Yi; Li, Si; Maxwell, Andrew S.; Peng, Yan; Li, Ying; Li, Haoni; Wu, Xi; Li, Peng; Huang, Tao; Wang, Nan; Zhang, Chaoyang] Univ So Mississippi, Sch Comp, Hattiesburg, MS 39406 USA. [Barker, Natalie D.; Gong, Ping] Badger Tech Serv LLC, San Antonio, TX 78216 USA. [Zhang, Chenhua] Univ So Mississippi, Dept Math, Hattiesburg, MS 39406 USA. [Perkins, Edward J.] US Army, Environm Lab, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Gong, P (reprint author), Badger Tech Serv LLC, San Antonio, TX 78216 USA. NR 12 TC 1 Z9 1 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 2150-3001 BN 978-1-4799-3462-1 J9 IEEE INT WORK GENOM PY 2013 BP 45 EP 48 PG 4 WC Engineering, Biomedical; Engineering, Electrical & Electronic SC Engineering GA BC1ZA UT WOS:000350564300015 ER PT J AU Torrieri, D Talarico, S Valenti, MC AF Torrieri, Don Talarico, Salvatore Valenti, Matthew C. GP IEEE TI Multihop Routing in Ad Hoc Networks SO 2013 IEEE MILITARY COMMUNICATIONS CONFERENCE (MILCOM 2013) LA English DT Proceedings Paper CT IEEE Military Communications Conference CY NOV 18-20, 2013 CL BAE Syst, San Diego, CA SP IEEE, IEEE Comp Soc, AFCEA, IEEE Commun Soc, MITRE HO BAE Syst ID CAPACITY AB This paper presents a dual method of closed-form analysis and lightweight simulation that enables an evaluation of the performance of mobile ad hoc networks that is more realistic, efficient, and accurate than those found in existing publications. Some features accommodated by the new analysis are shadowing, exclusion and guard zones, and distance-dependent fading. Three routing protocols are examined: least-delay, nearest-neighbor, and maximum-progress routing. The tradeoffs among the path reliabilities, average conditional delays, average conditional number of hops, and area spectral efficiencies are examined. C1 [Torrieri, Don] US Army Res Lab, Adelphi, MD 20783 USA. [Talarico, Salvatore; Valenti, Matthew C.] West Virginia Univ, Morgantown, WV USA. RP Torrieri, D (reprint author), US Army Res Lab, Adelphi, MD 20783 USA. OI Valenti, Matthew/0000-0001-6089-0509 NR 12 TC 1 Z9 1 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA BN 978-0-7695-5124-1 PY 2013 BP 504 EP 509 DI 10.1109/MILCOM.2013.92 PG 6 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA BB8PB UT WOS:000347184000085 ER PT J AU Saldanha, NV Lai, HQ Nguyen, PQ Labib, MR Brown, B Baduini, S Clarkson, L Ernst, J Hilley, M Height, B Iezzi, S Yelverton, D AF Saldanha, Nancy V. Hung-Quoc Lai Nguyen, Phillip Q. Labib, Mary R. Brown, Brian Baduini, Shannon Clarkson, Leslie Ernst, Jeff Hilley, Mike Height, Brian Iezzi, Steve Yelverton, Dan GP IEEE TI Communications Performance Improvements of Mobile Networked MIMO in Army Operational Environments SO 2013 IEEE MILITARY COMMUNICATIONS CONFERENCE (MILCOM 2013) LA English DT Proceedings Paper CT IEEE Military Communications Conference CY NOV 18-20, 2013 CL BAE Syst, San Diego, CA SP IEEE, IEEE Comp Soc, AFCEA, IEEE Commun Soc, MITRE HO BAE Syst DE MIMO; mobile radio network; throughput improvement; multipath environment; military environment AB In recent years the military has been developing mobile Multiple-Input Multiple-Output (MIMO) technology. MIMO communications are attractive due to enhanced performance in urban, high multi-path environments which can cause substantial performance degradation in Single Input Single Output (SISO) communications. In this paper, results of a MIMO mobile network of 2 antenna MIMO radio systems employing spatial diversity, with four nodes in a hub-spoke configuration are given. The purpose was to validate MIMO mobile network performance over that of a SISO network. The experiments were conducted in several different environments such as reduced line of sight, heavily obstructive with buildings and dense foliage and high multipath environments and for On-The-Move (OTM) and At-The-Halt (ATH) test scenarios. Tests were conducted in SISO, MIMO and receiver diversity (RXD) modes for comparison and to show backwards compatibility to SISO radios. The paper highlights the advantages of the MIMO mobile network technology, showing improved throughput, reliable communications and coverage extension in mobile and reduced line of sight scenarios. The results consistently showed on average a 10% to 15% throughput improvement in MIMO over SISO given the same transmit power and operating range. C1 [Saldanha, Nancy V.; Hung-Quoc Lai; Nguyen, Phillip Q.; Labib, Mary R.] US Army, CERDEC S&TCD, Aberdeen Proving Ground, MD 21001 USA. [Brown, Brian; Baduini, Shannon; Clarkson, Leslie; Ernst, Jeff; Hilley, Mike; Height, Brian; Iezzi, Steve; Yelverton, Dan] Aeronix Inc, Melbourne, FL USA. RP Saldanha, NV (reprint author), US Army, CERDEC S&TCD, Aberdeen Proving Ground, MD 21001 USA. NR 6 TC 0 Z9 0 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA BN 978-0-7695-5124-1 PY 2013 BP 758 EP 763 DI 10.1109/MILCOM.2013.134 PG 6 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA BB8PB UT WOS:000347184000127 ER PT J AU Wang, P Henz, B AF Wang, Peng Henz, Brian GP IEEE TI Performance Analysis of Jammed Single-Hop Wireless Networks SO 2013 IEEE MILITARY COMMUNICATIONS CONFERENCE (MILCOM 2013) LA English DT Proceedings Paper CT IEEE Military Communications Conference CY NOV 18-20, 2013 CL BAE Syst, San Diego, CA SP IEEE, IEEE Comp Soc, AFCEA, IEEE Commun Soc, MITRE HO BAE Syst ID JAMMING ATTACKS AB We develop a theoretical approach to derive system throughput for single-hop wireless networks with N independent channels, n users and m jammers where users and jammers follow the given policies to randomly select channels at each time slot. The whole system, named as NRL model, can be modeled as a Markov chain, and the system state at each time slot is defined as the number of successful jammers. The key point is to derive the transition probability matrix and obtain the stationary distribution. Then, the theoretical system throughput can be computed straightforwardly. Numerical experiments are used to validate theoretical results, and the throughput differences between numerical and theoretical results are within 0.3%. Also, we derive the theoretical throughput for a Dumb model where users and jammers randomly select channels at each time slot. Compared with Dumb model, NRL model achieves better performance for big n and worse performance for small n. C1 [Wang, Peng; Henz, Brian] Army Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Wang, P (reprint author), Army Res Lab, Aberdeen Proving Ground, MD 21005 USA. NR 9 TC 0 Z9 0 U1 0 U2 1 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA BN 978-0-7695-5124-1 PY 2013 BP 910 EP 915 DI 10.1109/MILCOM.2013.158 PG 6 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA BB8PB UT WOS:000347184000152 ER PT J AU Glodek, W Harang, R AF Glodek, William Harang, Richard GP IEEE TI Rapid Permissions-based Detection and Analysis of Mobile Malware Using Random Decision Forests SO 2013 IEEE MILITARY COMMUNICATIONS CONFERENCE (MILCOM 2013) LA English DT Proceedings Paper CT IEEE Military Communications Conference CY NOV 18-20, 2013 CL BAE Syst, San Diego, CA SP IEEE, IEEE Comp Soc, AFCEA, IEEE Commun Soc, MITRE HO BAE Syst DE android; mobile malware; machine learning; random decision forest ID DEVICES AB The explosion in mobile malware has led to the need for early, rapid detection mechanisms that can detect malware and identify risky applications prior to their deployment on end-user devices without the high cost of manual static and dynamic analysis. Previous work has shown that specific combinations of Android permissions, intents, broadcast receivers, native code and embedded applications can be effectively used to identify potentially malicious applications. We extend this work by using frequent combinations of such attributes as training features for random decision forest classification of malicious and benign applications. We demonstrate that using combinations of frequently-occuring permissions in this manner significantly improves previous results, and provides true positive rates in excess of 90% while maintaining tractable false positive rates. This is true even with novel malware that is not reliably detected at the time of release by conventional anti-malware tools. In addition, the auxiliary information generated by the random decision forest algorithm provides useful insights into the key indicators of malicious activity and the functionality of the associated malware. C1 [Glodek, William] US Army Res Lab, Adelphi, MD 20783 USA. [Harang, Richard] ICF Int, Seattle, WA USA. RP Glodek, W (reprint author), US Army Res Lab, Adelphi, MD 20783 USA. EM william.j.glodek.civ@mail.mil; richard.e.harang.ctr@mail.mil NR 43 TC 2 Z9 2 U1 0 U2 3 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA BN 978-0-7695-5124-1 PY 2013 BP 980 EP 985 DI 10.1109/MILCOM.2013.170 PG 6 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA BB8PB UT WOS:000347184000164 ER PT J AU Zeng, H Deng, HM Meng, K Luo, S Yu, X Mody, AN Sherman, M Muller, J Wang, ZX AF Zeng, Hui Deng, Hongmei (Julia) Meng, Ke Luo, Song Yu, Xiang Mody, Apurva N. Sherman, Matthew Muller, Jude Wang, Zhenxing GP IEEE TI From Spectrum Agility to Network Agility: Proactive and Adaptive Reconfiguration forReliable Communication in Tactical Networks SO 2013 IEEE MILITARY COMMUNICATIONS CONFERENCE (MILCOM 2013) LA English DT Proceedings Paper CT IEEE Military Communications Conference CY NOV 18-20, 2013 CL BAE Syst, San Diego, CA SP IEEE, IEEE Comp Soc, AFCEA, IEEE Commun Soc, MITRE HO BAE Syst DE Network Agility; Spectrum Agility; Cognitive Networks; Network Adaptation; Cross-Layer Design; Reconfiguration; WIN-T LAW; Tactical Networks AB In tactical networks reliable communication is a vital military issue that needs to be resolved. A large number of research efforts are currently focused on providing radios with spectrum agility. However, in many cases, spectrum agility is not enough to achieve reliable communications in tactical networks. Instead, mission success often requires network agility - cognition across the protocol layers for environmental awareness and autonomous reconfiguration - which is still an unsolved challenge to our best knowledge, and needs to be addressed. Toward this, we have developed a proactive and adaptive cross-layer reconfiguration (PACR) framework for autonomous network adaptation through network monitoring, proactive prediction, network performance characterization, root-cause analysis, and cross-layer negotiation. Although PACR is generically applicable to any radio network, for validation it has been prototyped and demonstrated on two specific networks - a commercial off-the-shelf (COTS) hardware testbed using IEEE 802.11 WiFi devices, and a military radio testbed using Warfighter Information Network - Tactical (WIN-T) Local Area Waveform (LAW) radios. Through tests and demonstrations, it has been shown that our solution provides cross-layer adaptation demonstrating spectrum as well as network agility, resulting in mission success through cognitive networking. C1 [Zeng, Hui; Deng, Hongmei (Julia); Meng, Ke; Luo, Song; Yu, Xiang] IAI, Rockville, MD 20855 USA. [Mody, Apurva N.; Sherman, Matthew; Muller, Jude] BAE Syst, Nashua, NH 03061 USA. [Wang, Zhenxing] US Army, CERDEC APG, Aberdeen Proving Ground, MD 21001 USA. RP Zeng, H (reprint author), IAI, Rockville, MD 20855 USA. FU Army CERDEC [W15P7T-11-C-A020] FX We thank the Army CERDEC for funding this effort under the contract W15P7T-11-C-A020. We also give our thanks to Ms. Sharon Mackey, Mr. Mitesh Patel, Mr. John Jeski, Mr. Charles Graff, and other Army CERDEC personnel/contractors for their valuable comments and suggestions during this effort. At BAE Systems, we also thank Kwok Yau and Jim Shedden for their support and Sharon Sputz for her advice during this effort. NR 10 TC 3 Z9 3 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA BN 978-0-7695-5124-1 PY 2013 BP 1663 EP 1668 DI 10.1109/MILCOM.2013.282 PG 6 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA BB8PB UT WOS:000347184000277 ER PT J AU Bakdash, JZ Pizzocaro, D Precee, A AF Bakdash, Jonathan Z. Pizzocaro, Diego Precee, Alun GP IEEE TI Human Factors in Intelligence, Surveillance, and Reconnaissance: Gaps for Soldiers and Technology Recommendations SO 2013 IEEE MILITARY COMMUNICATIONS CONFERENCE (MILCOM 2013) LA English DT Proceedings Paper CT IEEE Military Communications Conference CY NOV 18-20, 2013 CL BAE Syst, San Diego, CA SP IEEE, IEEE Comp Soc, AFCEA, IEEE Commun Soc, MITRE HO BAE Syst DE intelligence; surveillance; and reconnaissance; ISR; human factors; human-systems integration; cognitive systems engineering; intelligence ID SYSTEMS AB We investigate the gaps for Soldiers in information collection and resource management for Intelligence, Surveillance, and Reconnaissance (ISR). ISR comprises the intelligence functions supporting military operations; we concentrate on ISR for physical sensors (air and ground platforms). To identify gaps, we use approaches from Human Factors (interactions between humans and technical systems to optimize human and system performance) at the level of Soldier functions/activities in ISR. Key gaps (e.g., the loud auditory signatures of some air assets, unofficial ISR requests, and unintended battlefield effects) are identified. These gaps illustrate that ISR is not purely a technical problem. Instead, interactions between technical systems, humans, and the environment result in unpredictability and adaptability in using technical systems. To mitigate these gaps, we provide technology recommendations. C1 [Bakdash, Jonathan Z.] US Army Res Lab, Human Res & Engn Directorate, Aberdeen Proving Ground, MD 21005 USA. [Pizzocaro, Diego; Precee, Alun] Cardiff Univ, Sch Comp Sci & Informat, Cardiff, Wales. RP Bakdash, JZ (reprint author), US Army Res Lab, Human Res & Engn Directorate, Aberdeen Proving Ground, MD 21005 USA. EM jonathan.z.bakdash@us.army.mil; D.Pizzocaro@cs.cardiff.ac.uk; A.D.Preece@cs.cardiff.ac.uk FU U.S. Army Research Laboratory; U.K. Ministry of Defence [W911NF-06-3-0001] FX This research was sponsored by the U.S. Army Research Laboratory and the U.K. Ministry of Defence and was accomplished under Agreement Number W911NF-06-3-0001. The views and conclusions contained in this document are those of the authors and should not be interpreted as representing the official policies, either expressed or implied, of the U.S. Army Research Laboratory, the U.S. Government, the U.K. Ministry of Defense, or the U.K. Government. The U.S. and U.K. Governments are authorized to reproduce and distribute reprints for Government purposes notwithstanding any copyright notation herein. NR 34 TC 1 Z9 1 U1 1 U2 3 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA BN 978-0-7695-5124-1 PY 2013 BP 1900 EP 1905 DI 10.1109/MILCOM.2013.320 PG 6 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA BB8PB UT WOS:000347184000315 ER PT S AU Darwish, AM Hung, HA Ibrahim, AA AF Darwish, Ali M. Hung, H. Alfred Ibrahim, Amr A. GP IEEE TI A Ring-HEMT for Improved GaN MMIC Thermal Dissipation SO 2013 IEEE MTT-S INTERNATIONAL MICROWAVE SYMPOSIUM DIGEST (IMS) SE IEEE MTT-S International Microwave Symposium LA English DT Proceedings Paper CT IEEE MTT-S International Microwave Symposium Digest (IMS) CY JUN 02-07, 2013 CL Seattle, WA SP IEE MTT S DE GaN HEMT; FET; Junction Temperature; Thermal Resistance; Reliability AB A novel GaN HEMT which reduces the junction temperature is presented. The new structure uses a ring-like layout for the gate stripes, aimed at increasing the separation between stripes. Simulation and experimental results indicate improved performance of the Ring-HEMT, stemming from thermal effects and their interaction with device parameters. Compared to a regular HEMT, the new HEMT showed a decrease in junction temperature of 40 degrees C from 178 degrees C resulting in a significant improvement in output power, and 43x fold increase in lifetime. C1 [Darwish, Ali M.; Ibrahim, Amr A.] Amer Univ Cairo, New Cairo, Egypt. [Hung, H. Alfred] Army Res Lab, Adelphi, MD 20783 USA. RP Darwish, AM (reprint author), Army Res Lab, Adelphi, MD 20783 USA. EM darwish@alum.mit.edu; hahung@alum.mit.edu; amralaa87@gmail.com NR 14 TC 0 Z9 0 U1 1 U2 1 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 0149-645X BN 978-1-4673-2141-9; 978-1-4673-6177-4 J9 IEEE MTT S INT MICR PY 2013 PG 3 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA BE2OX UT WOS:000369754300301 ER PT S AU Ezzeddine, A Hung, HA Viveiros, E Huang, HC AF Ezzeddine, Amin Hung, H. Alfred Viveiros, Ed Huang, Ho-Chung GP IEEE TI High-Power GaN MMIC PA Over 40-4000MHz SO 2013 IEEE MTT-S INTERNATIONAL MICROWAVE SYMPOSIUM DIGEST (IMS) SE IEEE MTT-S International Microwave Symposium LA English DT Proceedings Paper CT IEEE MTT-S International Microwave Symposium Digest (IMS) CY JUN 02-07, 2013 CL Seattle, WA SP IEE MTT S DE Broadband amplifiers; high-voltage techniques; microwave devices; GaN MMIC PA AB We report a high-performance GaN MMIC power amplifier operating from 40MHz to 4,000MHz. The MMIC achieved 80W pulsed (100us pulse width and 10% duty cycle) output power (P5dB) with 54% efficiency at 40MHz, 50W with about 30% efficiency across most of the mid band, and gradually decreases to 30W with 22% efficiency at 4000MHz. Power gain is 25dB across the 40-4000MHz band. This ultra wideband performance is achieved by both tailoring the device output impedance, and using a unique wide-band, circuit-matching topology. Detailed design techniques of both the device and the matching circuit will be presented. C1 [Ezzeddine, Amin; Huang, Ho-Chung] AMCOM Commun Inc, 401 Profess Dr, Gaithersburg, MD 20879 USA. [Hung, H. Alfred; Viveiros, Ed] US Army Res Lab, Adelphi, MD USA. RP Ezzeddine, A (reprint author), AMCOM Commun Inc, 401 Profess Dr, Gaithersburg, MD 20879 USA. NR 8 TC 0 Z9 0 U1 1 U2 1 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 0149-645X BN 978-1-4673-2141-9; 978-1-4673-6177-4 J9 IEEE MTT S INT MICR PY 2013 PG 4 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA BE2OX UT WOS:000369754300038 ER PT S AU Okusaga, O Cahill, J Zhou, WM Menyuk, CR Carter, GM AF Okusaga, Olukayode Cahill, James Zhou, Weimin Menyuk, Curtis R. Carter, Gary M. GP IEEE TI Noise Sources in Microwave Photonic Links SO 2013 IEEE PHOTONICS CONFERENCE (IPC) SE IEEE Photonics Conference LA English DT Proceedings Paper CT 26th IEEE Photonics Conference (IPC) CY SEP 08-12, 2013 CL Bellevue, WA SP IEEE, Amer Chem Soc, Multidisciplinary Digital Publishing Inst, IEEE Cloud Comp, LioniX C1 [Okusaga, Olukayode; Cahill, James; Zhou, Weimin] US Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. [Cahill, James; Menyuk, Curtis R.; Carter, Gary M.] Univ Maryland Baltimore Cty, Baltimore, MD 21250 USA. RP Okusaga, O (reprint author), US Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. NR 4 TC 0 Z9 0 U1 1 U2 1 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 2374-0140 BN 978-1-4577-1507-5 J9 IEEE PHOTON CONF PY 2013 BP 193 EP 194 PG 2 WC Engineering, Electrical & Electronic; Optics SC Engineering; Optics GA BE2RE UT WOS:000369918000105 ER PT S AU Ghionea, S Smith, G Pulskamp, J Bedair, S Meyer, C Hull, D AF Ghionea, Simon Smith, Gabriel Pulskamp, Jeffrey Bedair, Sarah Meyer, Christopher Hull, David GP IEEE TI MEMS Electric-Field Sensor With Lead Zirconate Titanate (PZT)-Actuated Electrodes SO 2013 IEEE SENSORS SE IEEE Sensors LA English DT Proceedings Paper CT 12th IEEE Sensors Conference CY NOV 03-06, 2013 CL Baltimore, MD SP IEEE, IEEE Sensors Council ID INDUCTORS AB A microelectromechanical system (MEMS) electricfield sensor (EFS) is presented in which the ambient electric field (E-Field) is modulated by vertical electrode displacement using lead-zirconate-titanate (PZT) piezoelectric actuators. The device is fabricated with a multi-layer copper-on-PZT process, which enables large (similar to 10 mu m) displacement and high aspect ratio electrode structures as needed for sensitive detection. The modulated displacement current between two electrodes, measured using a transimpedance amplifier, is proportional to the ambient, sensed E-Field. Fabricated EFS devices yielded a responsivity of 830 fA/(V/m) and a limit of detection down to 0.19 V/m/rtHz in vacuum (0.30 V/m/rtHz in air) with a 491-Hz E-field applied. C1 [Ghionea, Simon; Smith, Gabriel; Pulskamp, Jeffrey; Bedair, Sarah; Meyer, Christopher; Hull, David] US Army Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA. RP Ghionea, S (reprint author), US Army Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA. EM simon.j.ghionea.civ@mail.mil NR 17 TC 0 Z9 0 U1 1 U2 1 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 1930-0395 BN 978-1-4673-4642-9 J9 IEEE SENSOR PY 2013 BP 33 EP 36 PG 4 WC Engineering, Electrical & Electronic; Remote Sensing SC Engineering; Remote Sensing GA BF0XP UT WOS:000379846100010 ER PT S AU Browning, CA Vinci, SJ Zhu, J Hull, DM Noras, MA AF Browning, Cassandra A. Vinci, Stephen J. Zhu, Jack Hull, David M. Noras, Maciej A. GP IEEE TI An Evaluation of Electric-Field Sensors for Projectile Detection SO 2013 IEEE SENSORS SE IEEE Sensors LA English DT Proceedings Paper CT 12th IEEE Sensors Conference CY NOV 03-06, 2013 CL Baltimore, MD SP IEEE, IEEE Sensors Council AB The U.S. Army Research Laboratory (ARL) conducted an experiment at Aberdeen Proving Ground (APG), MD, to collect bullet signature data using three different types of electric-field sensors. The first type is a free-space electric potential sensor; we used Remote Voltage Sensors (RVSs) manufactured by Quasar Federal Systems (QFS). The second type of sensor measures the electric field; we used QFS potential gradiometers and a varactor-based E-field sensor prototype designed by the University of North Carolina - Charlotte (UNCC). The third type of sensor is a "D-dot" charge induction probe designed and built by ARL. We analyzed the performance of each sensor type with regard to bullet detection capability. Mathematical models and signatures were developed for each sensor type, and actual signatures were measured and compared to these models. C1 [Browning, Cassandra A.; Vinci, Stephen J.; Zhu, Jack; Hull, David M.] US Army Res Lab, Adelphi, MD USA. [Noras, Maciej A.] Univ N Carolina, Engn Technol Dept, Charlotte, NC 28223 USA. RP Browning, CA (reprint author), US Army Res Lab, Adelphi, MD USA. EM cassandra.a.browning.ctr@mail.mil NR 6 TC 0 Z9 0 U1 1 U2 1 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 1930-0395 BN 978-1-4673-4642-9 J9 IEEE SENSOR PY 2013 BP 1250 EP 1253 PG 4 WC Engineering, Electrical & Electronic; Remote Sensing SC Engineering; Remote Sensing GA BF0XP UT WOS:000379846100300 ER PT S AU Damarla, T Mehmood, A AF Damarla, Thyagaraju Mehmood, Asif GP IEEE TI Detection of targets using distributed multi-modal sensors with correlated observations SO 2013 IEEE SENSORS SE IEEE Sensors LA English DT Proceedings Paper CT 12th IEEE Sensors Conference CY NOV 03-06, 2013 CL Baltimore, MD SP IEEE, IEEE Sensors Council AB Multiple unattended ground sensors (UGSs) equipped with seismic, passive infrared (PIR) and ultrasonic sensors are used to detect and track people for better situational awareness. The majority of the false alarms are caused by animals. We fuse the detections of individual sensors at each node using algorithms based on the Neyman-Pearson criteria to achieve the required false alarm rate with the assumption that the sensor observations are independent. However, the sensors are observing the same phenomenon and hence the observations are not independent. In this paper, we explore the joint probability distributions between the sensors using copulas to improve the detection statistics. We identify several copula functions suitable for fusing the data in order to improve the detection statistics. C1 [Damarla, Thyagaraju] US Army Res Lab, Networked Sensing & Fus Branch, Adelphi, MD 20783 USA. [Mehmood, Asif] Booz Allen Hamilton, Belcamp, MD USA. RP Damarla, T (reprint author), US Army Res Lab, Networked Sensing & Fus Branch, Adelphi, MD 20783 USA. EM thyagaraju.damarla.civ@mail.mil; asif.kyani@gmail.com NR 7 TC 0 Z9 0 U1 1 U2 1 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 1930-0395 BN 978-1-4673-4642-9 J9 IEEE SENSOR PY 2013 BP 1366 EP 1369 PG 4 WC Engineering, Electrical & Electronic; Remote Sensing SC Engineering; Remote Sensing GA BF0XP UT WOS:000379846100330 ER PT S AU Holthoff, EL Marcus, LS Pellegrino, PM AF Holthoff, Ellen L. Marcus, Logan S. Pellegrino, Paul M. GP IEEE TI Towards the Realization of a MEMS-based Photoacoustic Chemical Sensor Using Ultracompact EC-QCL (SpriteIR) SO 2013 IEEE SENSORS SE IEEE Sensors LA English DT Proceedings Paper CT 12th IEEE Sensors Conference CY NOV 03-06, 2013 CL Baltimore, MD SP IEEE, IEEE Sensors Council ID QUANTUM CASCADE LASER; SPECTROSCOPY; CELL AB Traditionally, chemical sensing platforms have been hampered by the opposing concerns of maximizing sensor capability while minimizing package size. Current sensors, although reasonably sized, are geared to more classical chemical threats, and the ability to expand their capabilities to a broader range of emerging threats is uncertain. Recently, photoacoustic spectroscopy, employed in a sensor format, has shown enormous potential to address these ever-changing threats, while maintaining a compact sensor design. The objective of the present work is to demonstrate the detection capability of a microelectromechanical systems (MEMS)-based photoacoustic chemical sensor using SpriteIR, an ultracompact external cavity quantum cascade laser (EC-QCL). C1 [Holthoff, Ellen L.; Marcus, Logan S.; Pellegrino, Paul M.] United States Army Res Lab, RDRL SEE E, Adelphi, MD USA. RP Holthoff, EL (reprint author), United States Army Res Lab, RDRL SEE E, Adelphi, MD USA. EM ellen.l.holthoff.civ@mail.mil NR 13 TC 0 Z9 0 U1 1 U2 1 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 1930-0395 BN 978-1-4673-4642-9 J9 IEEE SENSOR PY 2013 BP 1518 EP 1521 PG 4 WC Engineering, Electrical & Electronic; Remote Sensing SC Engineering; Remote Sensing GA BF0XP UT WOS:000379846100370 ER PT J AU Morelli, A Stefanelli, C Tortonesi, M Suni, N AF Morelli, Alessandro Stefanelli, Cesare Tortonesi, Mauro Suri, Niranjan GP IEEE TI Mobility Pattern Prediction to Support Opportunistic Networking in Smart Cities SO 2013 INTERNATIONAL CONFERENCE ON MOBILE WIRELESS MIDDLEWARE, OPERATING SYSTEMS AND APPLICATIONS (MOBILWARE 2013) LA English DT Proceedings Paper CT International Conference on MOBILe Wireless MiddleWARE, Operating Systems and Applications (Mobilware) CY NOV 11-13, 2013 CL Bologna, ITALY SP IEEE Comp Soc DE Smart City; opportunistic networking; mobile data offloading; prediction model; communication middleware AB The ever increasing number of mobile devices in Smart Cities and their heavy use, not only for personal communication but also as a distributed network of sensors, generate a data deluge that stresses the traditional wireless communication infrastructure. The opportunistic networking paradigm seems particularly well suited to the Smart City scenario because it exploits resources that temporarily fall into the connection range of mobile devices as communication proxies, thereby providing cheaper and more energy efficient alternatives to the use of the cellular city network and actively contributing to its offloading. However, its efficacy highly depends on the effectiveness of discovering and using those resources. To improve the effectiveness of opportunistic networking in Smart Cities, we propose a solution which exploits a prediction model tailored for the urban environment that, by detecting complex recurring patterns in nodes' contacts, can forecast the future availability of strategic communication resources. Experimental results obtained in a simulated environment show that our solution can improve the dissemination process and ease the access to the wired network infrastructure. C1 [Morelli, Alessandro; Stefanelli, Cesare; Tortonesi, Mauro] Univ Ferrara, I-44100 Ferrara, Italy. [Suri, Niranjan] Florida Inst Human & Machine Cognit, Pensacola, FL USA. [Suri, Niranjan] US Army Res Lab, Adelphi, MD USA. RP Morelli, A (reprint author), Univ Ferrara, I-44100 Ferrara, Italy. EM alessandro.morelli@unife.it; cesare.stefanelli@unife.it; mauro.tortonesi@unife.it; nsuri@ihmc.us OI Tortonesi, Mauro/0000-0002-7417-4455; Morelli, Alessandro/0000-0003-3309-3461 NR 25 TC 2 Z9 2 U1 1 U2 3 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA PY 2013 BP 166 EP 175 DI 10.1109/Mobilware.2013.23 PG 10 WC Computer Science, Hardware & Architecture; Computer Science, Information Systems SC Computer Science GA BC4QK UT WOS:000352849500020 ER PT S AU Solanki, A Nasiri, A Bhavaraju, V Abdullah, T Yu, D AF Solanki, A. Nasiri, A. Bhavaraju, V. Abdullah, T. Yu, D. GP IEEE TI A New Control Method for Microgrid Power Management SO 2013 INTERNATIONAL CONFERENCE ON RENEWABLE ENERGY RESEARCH AND APPLICATIONS (ICRERA) SE International Conference on Renewable Energy Research and Applications LA English DT Proceedings Paper CT International Conference on Renewable Energy Research and Applications (ICRERA) CY OCT 20-23, 2013 CL Madrid, SPAIN SP Int Journal Renewable Energy Res, Comillas Pontif Univ, IEEE, IEEE Power Elect Soc, IEEE Ind Applicat Soc, IBERDROLA, KBSoftware, Asociac Ingenieros ICAI, IEEE Secc Espana, IEEE Spanish Power Elect Ind Elect Joint Chapter, Univ Deusto, iMS, bime, Fraunhofer, INESCTEC, Aalborg Univ, CARTIF, EiC, European Commiss & Inst Elect Informat & Commun Engineers Japan, Natl Assoc Spanish ICAI Engineers DE Distributed generation; droop control; islanding; microgrid; power quality; renewable energy; unit commitment; power management AB Microgrids are receiving tremendous attention due to increasing need to integrate Distributed Generations (DG) and to provide reliable power to critical loads. Proper power management in microgrid is required to regulate the system voltage and frequency, maintain power quality, and manage DGs. A microgrid system has been studied in this paper, which includes two natural gas generators, an energy storage device, solar PV, and a wind turbine. The DGs are modeled in details using PSCAD software and the practical constraints of the components are considered. The Virtual Droop Control (VDC) method for microgrid power management is proposed and described in details. The proposed technique has been applied to adjust the active and reactive power of each component in order to manage the system. Unit commitment algorithm has also been implemented to improve the system efficiency. C1 [Solanki, A.; Nasiri, A.; Yu, D.] Univ Wisconsin, Milwaukee, WI 53201 USA. [Bhavaraju, V.] Eaton Corp Innovation Ctr, Menomonee Falls, WI 53051 USA. [Abdullah, T.] US Army, Champaign, IL USA. RP Solanki, A (reprint author), Univ Wisconsin, Milwaukee, WI 53201 USA. EM nasiri@uwm.edu; VijayBhavaraju@eaton.com; tarek.abdallah@erdc.usace.army.mil NR 14 TC 1 Z9 1 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 2377-6897 BN 978-1-4799-1464-7 J9 INT CONF RENEW ENERG PY 2013 BP 1212 EP 1216 PG 5 WC Energy & Fuels SC Energy & Fuels GA BC5XZ UT WOS:000353637100214 ER PT S AU Cahill, JP Carter, GM Menyuk, CR Pritchett, J Sorenson, R Berman, M Okusaga, O Zhou, WM AF Cahill, James P. Carter, Gary M. Menyuk, Curtis R. Pritchett, Justin Sorenson, Ryan Berman, Morris Okusaga, Olukayode Zhou, Weimin GP IEEE TI Inverse Relationship Between the OEO Q-factor and Vibration Sensitivity SO 2013 JOINT EUROPEAN FREQUENCY AND TIME FORUM & INTERNATIONAL FREQUENCY CONTROL SYMPOSIUM (EFTF/IFC) SE Joint European Frequency and Time Forum and International Frequency Control Symposium LA English DT Proceedings Paper CT Joint European Frequency and Time Forum / International Frequency Control Symposium (EFTF/IFC) CY JUL 21-25, 2013 CL Prague, CZECH REPUBLIC DE Microwave oscillator; vibration sensitivity; optoelectronic oscillator ID OPTOELECTRONIC OSCILLATOR AB External vibrations induce phase noise in low noise oscillators such as the OEO (opto-electronic oscillator). The gsensitivity quantifies the efficiency of this process. In fiber-based OEOs, vibrations of the fiber spool dominate the generation of phase noise. In this case, we observe decreasing g-sensitivity with increasing Q-factor (i.e., fiber length). This result indicates the interplay of two effects. First, only a portion of the optical fiber is affected by vibrations of the spool, even though the entire spool is subjected to vibrations. For the spools that we studied, the effective length is less than 500 m. Second, as the Q-factor increases, an OEO "filtering" effect reduces the phase noise that is induced by a constant magnitude perturbation. These results can be used to optimize the g-sensitivity of fiber-based OEOs by either reducing it for low phase noise RF generation or increasing it for sensing applications. C1 [Cahill, James P.; Carter, Gary M.; Menyuk, Curtis R.] Univ Maryland, Dept Comp Sci & Elect Engn, Baltimore, MD 21201 USA. [Pritchett, Justin; Sorenson, Ryan; Berman, Morris; Okusaga, Olukayode; Zhou, Weimin] US Army, Res Lab, Adelphi, MD USA. RP Cahill, JP (reprint author), Univ Maryland, Dept Comp Sci & Elect Engn, Baltimore, MD 21201 USA. EM jcahill1@umbc.edu NR 7 TC 0 Z9 0 U1 0 U2 2 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 2327-1914 BN 978-1-4799-0342-9 J9 JOINT CONF IEEE INT PY 2013 BP 43 EP + PG 2 WC Automation & Control Systems; Computer Science, Information Systems; Engineering, Electrical & Electronic SC Automation & Control Systems; Computer Science; Engineering GA BC0YR UT WOS:000349844200011 ER PT S AU Okusaga, O Pritchett, J Sorenson, R Zhou, WM Berman, M Cahill, J Carter, GM Menyuk, CR AF Okusaga, Olukayode Pritchett, Justin Sorenson, Ryan Zhou, Weimin Berman, Morris Cahill, James Carter, Gary M. Menyuk, Curtis R. GP IEEE TI The OEO as an Acoustic Sensor SO 2013 JOINT EUROPEAN FREQUENCY AND TIME FORUM & INTERNATIONAL FREQUENCY CONTROL SYMPOSIUM (EFTF/IFC) SE Joint European Frequency and Time Forum and International Frequency Control Symposium LA English DT Proceedings Paper CT Joint European Frequency and Time Forum / International Frequency Control Symposium (EFTF/IFC) CY JUL 21-25, 2013 CL Prague, CZECH REPUBLIC DE Optoelectronic oscillators; acoustic sensing AB The optoelectronic oscillator (OEO) is a radiofrequency (RF) source that utilizes lengths of optical fiber in a ring resonator to create low-phase-noise signals. In this work, we demonstrate a novel fiber-optic acoustic sensor by measuring the modulation sidebands induced on the OEO's RF signal by an acoustic tone impinging on the fiber spool in the OEO. The narrow linewidth and high oscillating frequency of the OEO results in a sensor with both high signal-to-noise ratios and high spectral resolution. C1 [Okusaga, Olukayode; Pritchett, Justin; Sorenson, Ryan; Zhou, Weimin; Berman, Morris] US Army, Res Lab, Sensors & Elect Devices Div, Adelphi, MD 20783 USA. [Cahill, James; Carter, Gary M.; Menyuk, Curtis R.] Univ Maryland Baltimore Cty, Dept Comp Sci & Elect Engn, Baltimore, MD USA. RP Okusaga, O (reprint author), US Army, Res Lab, Sensors & Elect Devices Div, Adelphi, MD 20783 USA. EM Olukayode.k.okusaga.civ@mail.mil NR 5 TC 2 Z9 2 U1 0 U2 1 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 2327-1914 BN 978-1-4799-0342-9 J9 JOINT CONF IEEE INT PY 2013 BP 66 EP + PG 2 WC Automation & Control Systems; Computer Science, Information Systems; Engineering, Electrical & Electronic SC Automation & Control Systems; Computer Science; Engineering GA BC0YR UT WOS:000349844200017 ER PT B AU Weiss, SJ AF Weiss, Steven J. GP IEEE TI Simulation and Measurement of Low-Profile Antennas Realized with Isotropic and Anisotropic Magneto-Dielectrics SO 2013 USNC-URSI RADIO SCIENCE MEETING (JOINT WITH AP-S SYMPOSIUM) LA English DT Proceedings Paper CT IEEE AP-S/URSI-USNC Symposium CY JUL 07-13, 2013 CL Lake Buena Vista, FL SP Inst Elect & Elect Engineers, IEEE Antennas & Propagat Soc, URSI, USNC C1 US Army, Res Lab, Adelphi, MD 20783 USA. RP Weiss, SJ (reprint author), US Army, Res Lab, Adelphi, MD 20783 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA BN 978-1-4799-1128-8; 978-1-4799-1129-5 PY 2013 BP 20 EP 20 PG 1 WC Engineering, Electrical & Electronic; Physics, Applied SC Engineering; Physics GA BC0ZE UT WOS:000349862100020 ER PT B AU Khalil, M Breakall, JK Minko, G Parsons, P Duncan, K AF Khalil, Mohamed Breakall, James K. Minko, Glenn Parsons, Paul Duncan, Kate GP IEEE TI Simulation and Experimental Results for a Planar Strip Dipole over PEC and Ferrite Nanoparticle Composite Ground Planes SO 2013 USNC-URSI RADIO SCIENCE MEETING (JOINT WITH AP-S SYMPOSIUM) LA English DT Proceedings Paper CT IEEE AP-S/URSI-USNC Symposium CY JUL 07-13, 2013 CL Lake Buena Vista, FL SP Inst Elect & Elect Engineers, IEEE Antennas & Propagat Soc, URSI, USNC C1 [Khalil, Mohamed; Minko, Glenn; Duncan, Kate] US Army, S&TCD CERDEC, Aberdeen Proving Ground, MD 21005 USA. [Breakall, James K.] Penn State Univ, EE Dept, University Pk, PA 16802 USA. [Parsons, Paul] Univ Delaware, Dept Phys & Astron, Newark, DE 19716 USA. [Parsons, Paul] US Army, ARL, Aberdeen Proving Ground, MD 21005 USA. RP Khalil, M (reprint author), US Army, S&TCD CERDEC, Aberdeen Proving Ground, MD 21005 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA BN 978-1-4799-1128-8; 978-1-4799-1129-5 PY 2013 BP 56 EP 56 PG 1 WC Engineering, Electrical & Electronic; Physics, Applied SC Engineering; Physics GA BC0ZE UT WOS:000349862100054 ER PT B AU Zaghloul, AI Coburn, WO Jenkins, LL AF Zaghloul, Amir I. Coburn, W. O'Keefe Jenkins, Louis L., II GP IEEE TI Spherical Meander Dipole with Optimum Filling Configuration SO 2013 USNC-URSI RADIO SCIENCE MEETING (JOINT WITH AP-S SYMPOSIUM) LA English DT Proceedings Paper CT IEEE AP-S/URSI-USNC Symposium CY JUL 07-13, 2013 CL Lake Buena Vista, FL SP Inst Elect & Elect Engineers, IEEE Antennas & Propagat Soc, URSI, USNC C1 [Zaghloul, Amir I.; Coburn, W. O'Keefe; Jenkins, Louis L., II] US Army Res Lab, Adelphi, MD 20783 USA. RP Zaghloul, AI (reprint author), US Army Res Lab, Adelphi, MD 20783 USA. EM amir.zaghloul.civ@mail.mil NR 0 TC 0 Z9 0 U1 0 U2 2 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA BN 978-1-4799-1128-8; 978-1-4799-1129-5 PY 2013 BP 96 EP 96 PG 1 WC Engineering, Electrical & Electronic; Physics, Applied SC Engineering; Physics GA BC0ZE UT WOS:000349862100093 ER PT B AU Price, S Donohoe, JP Fairley, JR AF Price, Steven Donohoe, J. Patrick Fairley, Josh R. GP IEEE TI Effects of Wall Moisture Profiles on Matched Illumination Waveforms SO 2013 USNC-URSI RADIO SCIENCE MEETING (JOINT WITH AP-S SYMPOSIUM) LA English DT Proceedings Paper CT IEEE AP-S/URSI-USNC Symposium CY JUL 07-13, 2013 CL Lake Buena Vista, FL SP Inst Elect & Elect Engineers, IEEE Antennas & Propagat Soc, URSI, USNC C1 [Price, Steven; Donohoe, J. Patrick] Mississippi State Univ, Dept Elect & Comp Engn, Mississippi State, MS 39762 USA. [Fairley, Josh R.] US Army, Res & Dev Ctr, Geotech & Struct Lab, Vicksburg, MS 39180 USA. RP Price, S (reprint author), Mississippi State Univ, Dept Elect & Comp Engn, Mississippi State, MS 39762 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA BN 978-1-4799-1128-8; 978-1-4799-1129-5 PY 2013 BP 177 EP 177 PG 1 WC Engineering, Electrical & Electronic; Physics, Applied SC Engineering; Physics GA BC0ZE UT WOS:000349862100173 ER PT B AU Mcknight, K Zaghloul, ME AF Mcknight, Ken Zaghloul, Mona E. GP IEEE TI GaN Non-Linear Modeling for Ka Band Resistive Mixer Design SO 2013 USNC-URSI RADIO SCIENCE MEETING (JOINT WITH AP-S SYMPOSIUM) LA English DT Proceedings Paper CT IEEE AP-S/URSI-USNC Symposium CY JUL 07-13, 2013 CL Lake Buena Vista, FL SP Inst Elect & Elect Engineers, IEEE Antennas & Propagat Soc, URSI, USNC C1 [Mcknight, Ken] US Army Res Lab, Adelphi, MD 20783 USA. [Mcknight, Ken; Zaghloul, Mona E.] George Washington Univ, Washington, DC 20052 USA. RP Mcknight, K (reprint author), US Army Res Lab, Adelphi, MD 20783 USA. EM kenneth.m.mcknight10.civ@mail.mil; zaghloul@gwu.edu NR 0 TC 0 Z9 0 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA BN 978-1-4799-1128-8; 978-1-4799-1129-5 PY 2013 BP 185 EP 185 PG 1 WC Engineering, Electrical & Electronic; Physics, Applied SC Engineering; Physics GA BC0ZE UT WOS:000349862100180 ER PT S AU Huddleston, SH Brown, DE AF Huddleston, Samuel H. Brown, Donald E. GP IEEE TI USING DISCRETE EVENT SIMULATION TO EVALUATE TIME SERIES FORECASTING METHODS FOR SECURITY APPLICATIONS SO 2013 WINTER SIMULATION CONFERENCE (WSC) SE Winter Simulation Conference Proceedings LA English DT Proceedings Paper CT Winter Simulation Conference on Simulation - Making Decisions in a Complex World CY DEC 08-11, 2013 CL Washington, DC SP Assoc Comp Machinery, Special Interest Grp Simulat, Amer Stat Assoc, Arbeitsgemeinschaft Simulat, Inst Elect & Elect Engineers, Syst, Man, & Cybernet Soc, Inst Ind Engineers, Inst Operat Res & Management Sci, Simulat Soc, Natl Inst Stand & Technol, Soc Modeling & Simulat Int ID BANDWIDTH SELECTION; DENSITY-ESTIMATION; CRIME; MODEL AB This paper documents the use of a discrete event simulation model to compare the effectiveness of forecasting systems available to support routine forecasts of criminal events in security applications. Military and police units regularly use forecasts of criminal events to divide limited resources, assign and redeploy special details, and conduct unit performance assessment. We use the simulation model to test the performance of available forecasting methods under a variety of conditions, including the presence of trends, seasonality, and shocks. We find that, in most situations, a simple forecasting method that fuses the outputs of crime hot-spot maps with the outputs of univariate time series methods both significantly reduces modeling workload and provides significant performance improvement over the three currently used methods: naive forecasts, Holt-Winters smoothing, and ARIMA models. C1 [Huddleston, Samuel H.] US Army, Ctr Army Anal, Ft Belvoir, VA 24061 USA. [Brown, Donald E.] Univ Virginia, Dept Syst & Informat Engn, Charlottesville, VA 22904 USA. RP Huddleston, SH (reprint author), US Army, Ctr Army Anal, Ft Belvoir, VA 24061 USA. EM shh4m@virginia.edu; deb@virginia.edu NR 15 TC 2 Z9 2 U1 1 U2 3 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 0891-7736 BN 978-1-4799-3950-3; 978-1-4799-2077-8 J9 WINT SIMUL C PROC PY 2013 BP 2772 EP + PG 2 WC Computer Science, Theory & Methods; Engineering, Electrical & Electronic SC Computer Science; Engineering GA BC0YO UT WOS:000349838403008 ER PT S AU Snively, K Leslie, R Gaughan, C AF Snively, Keith Leslie, Richard Gaughan, Chris GP IEEE TI RUNTIME EXECUTION MANAGEMENT OF DISTRIBUTED SIMULATIONS SO 2013 WINTER SIMULATION CONFERENCE (WSC) SE Winter Simulation Conference Proceedings LA English DT Proceedings Paper CT Winter Simulation Conference on Simulation - Making Decisions in a Complex World CY DEC 08-11, 2013 CL Washington, DC SP Assoc Comp Machinery, Special Interest Grp Simulat, Amer Stat Assoc, Arbeitsgemeinschaft Simulat, Inst Elect & Elect Engineers, Syst, Man, & Cybernet Soc, Inst Ind Engineers, Inst Operat Res & Management Sci, Simulat Soc, Natl Inst Stand & Technol, Soc Modeling & Simulat Int AB Distributed Modeling and Simulation (M&S) provides benefit from the ability to bring together a large number of simulations, across a network, to fulfill a specific requirement. However, this capability comes with the costs and complexity of coordinating all of the computing platforms for the startup, execution, shutdown and artifact collection of the simulation execution. Typically, an exercise event also requires many iterations of the simulation execution, necessitating the ability to perform these tasks in an efficient and repeatable manner. This paper discusses an approach to handle the runtime execution of a simulation exercise as part of the Executable Architecture Systems Engineering (EASE) research project. We discuss the methodologies used to control the overall execution of a distributed simulation as well as control the individual applications involved. We further present some of the current use cases for this approach and lessons identified. C1 [Snively, Keith] Dynam Animat Syst Inc, Fairfax, VA 22033 USA. [Leslie, Richard] Kinex Inc, Manassas, VA USA. [Gaughan, Chris] Simulat & Training Technol Ctr, Human Res & Engn Direct, Army Res Lab, Orlando, FL USA. RP Snively, K (reprint author), Dynam Animat Syst Inc, Fairfax, VA 22033 USA. EM ksnively@d-a-s.com; rleslie@kinex.com; OPS.STTC@peostri.army.mil NR 19 TC 1 Z9 1 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 0891-7736 BN 978-1-4799-3950-3; 978-1-4799-2077-8 J9 WINT SIMUL C PROC PY 2013 BP 2878 EP + PG 4 WC Computer Science, Theory & Methods; Engineering, Electrical & Electronic SC Computer Science; Engineering GA BC0YO UT WOS:000349838403017 ER PT B AU Atlas, RI DiGregorio, A AF Atlas, Randall I. DiGregorio, Anthony BA Atlas, RI BF Atlas, RI TI Terrorism and Infrastructure Protection Risks and Protection SO 21ST CENTURY SECURITY AND CPTED: DESIGNING FOR CRITICAL INFRASTRUCTURE PROTECTION AND CRIME PREVENTION, 2ND EDITION LA English DT Article; Book Chapter C1 [Atlas, Randall I.] Atlas Safety & Secur Design Inc, Ft Lauderdale, FL 33301 USA. [Atlas, Randall I.] ASIS, Alexandria, VA USA. [Atlas, Randall I.] ASTM, Tech Comm Correct F33, W Conshohocken, PA USA. [Atlas, Randall I.] ASTM, Tech Comm Detent Facil F33, W Conshohocken, PA USA. [Atlas, Randall I.] ASTM E54 Homeland Secur Comm, W Conshohocken, PA USA. [Atlas, Randall I.] F13 Pedestrian Walkway Safety & Footwear, Anaheim, CA USA. [DiGregorio, Anthony] US Army, Washington, DC USA. [DiGregorio, Anthony] Sverdrup Corp, St Louis, MO USA. [DiGregorio, Anthony] Appl Res Associates Inc, Albuquerque, NM USA. [DiGregorio, Anthony] Appl Res Associates Inc, Principal Tech Secur Advisor, Albuquerque, NM USA. [DiGregorio, Anthony] Loss Prevent Unltd LLC, Fairfax, VA USA. RP Atlas, RI (reprint author), Atlas Safety & Secur Design Inc, Ft Lauderdale, FL 33301 USA. NR 19 TC 0 Z9 0 U1 0 U2 0 PU CRC PRESS-TAYLOR & FRANCIS GROUP PI BOCA RATON PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA BN 978-1-4398-8022-7; 978-1-4398-8021-0 PY 2013 BP 147 EP 172 D2 10.1201/b15046 PG 26 WC Architecture; Criminology & Penology SC Architecture; Criminology & Penology GA BC2OA UT WOS:000351103400011 ER PT B AU Atlas, RI DiGregorio, A AF Atlas, Randall I. DiGregorio, Anthony BA Atlas, RI BF Atlas, RI TI Designing for Explosive Resistance SO 21ST CENTURY SECURITY AND CPTED: DESIGNING FOR CRITICAL INFRASTRUCTURE PROTECTION AND CRIME PREVENTION, 2ND EDITION LA English DT Article; Book Chapter C1 [Atlas, Randall I.] Atlas Safety & Secur Design Inc, Ft Lauderdale, FL 33301 USA. [Atlas, Randall I.] ASIS, Alexandria, VA USA. [Atlas, Randall I.] ASTM, Tech Comm Correct F33, W Conshohocken, PA USA. [Atlas, Randall I.] ASTM, Tech Comm Detent Facil F33, W Conshohocken, PA USA. [Atlas, Randall I.] ASTM E54 Homeland Secur Comm, W Conshohocken, PA USA. [DiGregorio, Anthony] US Army, Washington, DC USA. [DiGregorio, Anthony] Sverdrup Corp, Arlington, VA USA. [DiGregorio, Anthony] Appl Res Associates Inc, Albuquerque, NM USA. [DiGregorio, Anthony] Appl Res Associates Inc, Principal Tech Secur Advisor, Albuquerque, NM USA. [DiGregorio, Anthony] Loss Prevent Unltd LLC, Fairfax, VA USA. RP Atlas, RI (reprint author), Atlas Safety & Secur Design Inc, Ft Lauderdale, FL 33301 USA. NR 21 TC 0 Z9 0 U1 0 U2 0 PU CRC PRESS-TAYLOR & FRANCIS GROUP PI BOCA RATON PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA BN 978-1-4398-8022-7; 978-1-4398-8021-0 PY 2013 BP 253 EP 274 D2 10.1201/b15046 PG 22 WC Architecture; Criminology & Penology SC Architecture; Criminology & Penology GA BC2OA UT WOS:000351103400017 ER PT B AU Blair, JP Nichols, T Burns, D Curnutt, JR AF Blair, J. Pete Nichols, Terry Burns, David Curnutt, John R. BA Blair, JP Nichols, T Burns, D Curnutt, JR BF Blair, JP Nichols, T Burns, D Curnutt, JR TI Historical Perspective of Active Shooter Events SO ACTIVE SHOOTER: EVENTS AND RESPONSE LA English DT Article; Book Chapter C1 [Blair, J. Pete] Texas State Univ, Criminal Justice, San Marcos, TX 78666 USA. [Blair, J. Pete] ALERRT, Res, San Marcos, TX USA. [Nichols, Terry] Texas State Univ San Marcos, ALERRT Ctr, San Marcos, TX USA. [Nichols, Terry] San Marcos Police Dept, San Marcos, TX USA. [Burns, David] US Army, Airborne Div 82, Washington, DC USA. [Curnutt, John R.] ALERRT, Training, San Marcos, TX USA. [Curnutt, John R.] Patrol Div, Kansas City, MO USA. RP Blair, JP (reprint author), Texas State Univ, Criminal Justice, San Marcos, TX 78666 USA. NR 6 TC 0 Z9 0 U1 0 U2 1 PU CRC PRESS-TAYLOR & FRANCIS GROUP PI BOCA RATON PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA BN 978-1-4665-1231-3; 978-1-4665-1229-0 PY 2013 BP 1 EP 22 D2 10.1201/b14996 PG 22 WC Criminology & Penology SC Criminology & Penology GA BC2ZK UT WOS:000351464200002 ER PT B AU Blair, JP Nichols, T Burns, D Curnutt, JR AF Blair, J. Pete Nichols, Terry Burns, David Curnutt, John R. BA Blair, JP Nichols, T Burns, D Curnutt, JR BF Blair, JP Nichols, T Burns, D Curnutt, JR TI Active Shooter Events and Response Preface SO ACTIVE SHOOTER: EVENTS AND RESPONSE LA English DT Editorial Material; Book Chapter C1 [Blair, J. Pete] Texas State Univ, Criminal Justice, San Marcos, TX 78666 USA. [Blair, J. Pete] ALERRT, Res, San Marcos, TX USA. [Nichols, Terry] Texas State Univ San Marcos, ALERRT Ctr, San Marcos, TX USA. [Nichols, Terry] San Marcos Police Dept, San Marcos, TX USA. [Burns, David] US Army, Airborne Div 82, Washington, DC USA. [Curnutt, John R.] ALERRT, Training, San Marcos, TX USA. [Curnutt, John R.] Patrol Div, Kansas City, MO USA. RP Blair, JP (reprint author), Texas State Univ, Criminal Justice, San Marcos, TX 78666 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU CRC PRESS-TAYLOR & FRANCIS GROUP PI BOCA RATON PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA BN 978-1-4665-1231-3; 978-1-4665-1229-0 PY 2013 BP XI EP XIII D2 10.1201/b14996 PG 3 WC Criminology & Penology SC Criminology & Penology GA BC2ZK UT WOS:000351464200001 ER PT B AU Blair, JP Nichols, T Burns, D Curnutt, JR AF Blair, J. Pete Nichols, Terry Burns, David Curnutt, John R. BA Blair, JP Nichols, T Burns, D Curnutt, JR BF Blair, JP Nichols, T Burns, D Curnutt, JR TI Increased Complexity of Events SO ACTIVE SHOOTER: EVENTS AND RESPONSE LA English DT Article; Book Chapter C1 [Blair, J. Pete] Texas State Univ, Criminal Justice, San Marcos, TX 78666 USA. [Blair, J. Pete] ALERRT, Res, San Marcos, TX USA. [Nichols, Terry] Texas State Univ San Marcos, ALERRT Ctr, San Marcos, TX USA. [Nichols, Terry] San Marcos Police Dept, San Marcos, TX USA. [Burns, David] US Army, Airborne Div 82, Washington, DC USA. [Curnutt, John R.] ALERRT, Training, San Marcos, TX USA. [Curnutt, John R.] Patrol Div, Kansas City, MO USA. RP Blair, JP (reprint author), Texas State Univ, Criminal Justice, San Marcos, TX 78666 USA. NR 25 TC 0 Z9 0 U1 0 U2 0 PU CRC PRESS-TAYLOR & FRANCIS GROUP PI BOCA RATON PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA BN 978-1-4665-1231-3; 978-1-4665-1229-0 PY 2013 BP 23 EP 48 D2 10.1201/b14996 PG 26 WC Criminology & Penology SC Criminology & Penology GA BC2ZK UT WOS:000351464200003 ER PT B AU Blair, JP Nichols, T Burns, D Curnutt, JR AF Blair, J. Pete Nichols, Terry Burns, David Curnutt, John R. BA Blair, JP Nichols, T Burns, D Curnutt, JR BF Blair, JP Nichols, T Burns, D Curnutt, JR TI Active Shooter Events in the United States from 2000 to 2010 SO ACTIVE SHOOTER: EVENTS AND RESPONSE LA English DT Article; Book Chapter C1 [Blair, J. Pete] Texas State Univ, Criminal Justice, San Marcos, TX 78666 USA. [Blair, J. Pete] ALERRT, Res, San Marcos, TX USA. [Nichols, Terry] Texas State Univ San Marcos, ALERRT Ctr, San Marcos, TX USA. [Nichols, Terry] San Marcos Police Dept, San Marcos, TX USA. [Burns, David] US Army, Airborne Div 82, Washington, DC USA. [Curnutt, John R.] ALERRT, Training, San Marcos, TX USA. [Curnutt, John R.] Patrol Div, Kansas City, MO USA. RP Blair, JP (reprint author), Texas State Univ, Criminal Justice, San Marcos, TX 78666 USA. NR 3 TC 0 Z9 0 U1 0 U2 0 PU CRC PRESS-TAYLOR & FRANCIS GROUP PI BOCA RATON PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA BN 978-1-4665-1231-3; 978-1-4665-1229-0 PY 2013 BP 49 EP 64 D2 10.1201/b14996 PG 16 WC Criminology & Penology SC Criminology & Penology GA BC2ZK UT WOS:000351464200004 ER PT B AU Blair, JP Nichols, T Burns, D Curnutt, JR AF Blair, J. Pete Nichols, Terry Burns, David Curnutt, John R. BA Blair, JP Nichols, T Burns, D Curnutt, JR BF Blair, JP Nichols, T Burns, D Curnutt, JR TI Preparing for the Event SO ACTIVE SHOOTER: EVENTS AND RESPONSE LA English DT Article; Book Chapter C1 [Blair, J. Pete] Texas State Univ, Criminal Justice, San Marcos, TX 78666 USA. [Blair, J. Pete] ALERRT, Res, San Marcos, TX USA. [Nichols, Terry] Texas State Univ San Marcos, ALERRT Ctr, San Marcos, TX USA. [Nichols, Terry] San Marcos Police Dept, San Marcos, TX USA. [Burns, David] US Army, Airborne Div 82, Washington, DC USA. [Curnutt, John R.] ALERRT, Training, San Marcos, TX USA. [Curnutt, John R.] Patrol Div, Kansas City, MO USA. RP Blair, JP (reprint author), Texas State Univ, Criminal Justice, San Marcos, TX 78666 USA. NR 3 TC 0 Z9 0 U1 0 U2 0 PU CRC PRESS-TAYLOR & FRANCIS GROUP PI BOCA RATON PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA BN 978-1-4665-1231-3; 978-1-4665-1229-0 PY 2013 BP 65 EP 91 D2 10.1201/b14996 PG 27 WC Criminology & Penology SC Criminology & Penology GA BC2ZK UT WOS:000351464200005 ER PT B AU Blair, JP Nichols, T Burns, D Curnutt, JR AF Blair, J. Pete Nichols, Terry Burns, David Curnutt, John R. BA Blair, JP Nichols, T Burns, D Curnutt, JR BF Blair, JP Nichols, T Burns, D Curnutt, JR TI En Route and Actions Outside the Building SO ACTIVE SHOOTER: EVENTS AND RESPONSE LA English DT Article; Book Chapter C1 [Blair, J. Pete] Texas State Univ, Criminal Justice, San Marcos, TX 78666 USA. [Blair, J. Pete] ALERRT, Res, San Marcos, TX USA. [Nichols, Terry] Texas State Univ San Marcos, ALERRT Ctr, San Marcos, TX USA. [Nichols, Terry] San Marcos Police Dept, San Marcos, TX USA. [Burns, David] US Army, Airborne Div 82, Washington, DC USA. [Curnutt, John R.] ALERRT, Training, San Marcos, TX USA. [Curnutt, John R.] Patrol Div, Kansas City, MO USA. RP Blair, JP (reprint author), Texas State Univ, Criminal Justice, San Marcos, TX 78666 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU CRC PRESS-TAYLOR & FRANCIS GROUP PI BOCA RATON PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA BN 978-1-4665-1231-3; 978-1-4665-1229-0 PY 2013 BP 93 EP 111 D2 10.1201/b14996 PG 19 WC Criminology & Penology SC Criminology & Penology GA BC2ZK UT WOS:000351464200006 ER PT B AU Blair, JP Nichols, T Burns, D Curnutt, JR AF Blair, J. Pete Nichols, Terry Burns, David Curnutt, John R. BA Blair, JP Nichols, T Burns, D Curnutt, JR BF Blair, JP Nichols, T Burns, D Curnutt, JR TI Entry and Confronting the Threat SO ACTIVE SHOOTER: EVENTS AND RESPONSE LA English DT Article; Book Chapter C1 [Blair, J. Pete] Texas State Univ, Criminal Justice, San Marcos, TX 78666 USA. [Blair, J. Pete] ALERRT, Res, San Marcos, TX USA. [Nichols, Terry] Texas State Univ San Marcos, ALERRT Ctr, San Marcos, TX USA. [Nichols, Terry] San Marcos Police Dept, San Marcos, TX USA. [Burns, David] US Army, Airborne Div 82, Washington, DC USA. [Curnutt, John R.] ALERRT, Training, San Marcos, TX USA. [Curnutt, John R.] Patrol Div, Kansas City, MO USA. RP Blair, JP (reprint author), Texas State Univ, Criminal Justice, San Marcos, TX 78666 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU CRC PRESS-TAYLOR & FRANCIS GROUP PI BOCA RATON PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA BN 978-1-4665-1231-3; 978-1-4665-1229-0 PY 2013 BP 113 EP 146 D2 10.1201/b14996 PG 34 WC Criminology & Penology SC Criminology & Penology GA BC2ZK UT WOS:000351464200007 ER PT B AU Blair, JP Nichols, T Burns, D Curnutt, JR AF Blair, J. Pete Nichols, Terry Burns, David Curnutt, John R. BA Blair, JP Nichols, T Burns, D Curnutt, JR BF Blair, JP Nichols, T Burns, D Curnutt, JR TI Postengagement Priorities of Work SO ACTIVE SHOOTER: EVENTS AND RESPONSE LA English DT Article; Book Chapter C1 [Blair, J. Pete] Texas State Univ, Criminal Justice, San Marcos, TX 78666 USA. [Blair, J. Pete] ALERRT, Res, San Marcos, TX USA. [Nichols, Terry] Texas State Univ San Marcos, ALERRT Ctr, San Marcos, TX USA. [Nichols, Terry] San Marcos Police Dept, San Marcos, TX USA. [Burns, David] US Army, Airborne Div 82, Washington, DC USA. [Curnutt, John R.] ALERRT, Training, San Marcos, TX USA. [Curnutt, John R.] Patrol Div, Kansas City, MO USA. RP Blair, JP (reprint author), Texas State Univ, Criminal Justice, San Marcos, TX 78666 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU CRC PRESS-TAYLOR & FRANCIS GROUP PI BOCA RATON PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA BN 978-1-4665-1231-3; 978-1-4665-1229-0 PY 2013 BP 147 EP 171 D2 10.1201/b14996 PG 25 WC Criminology & Penology SC Criminology & Penology GA BC2ZK UT WOS:000351464200008 ER PT B AU Blair, JP Nichols, T Burns, D Curnutt, JR AF Blair, J. Pete Nichols, Terry Burns, David Curnutt, John R. BA Blair, JP Nichols, T Burns, D Curnutt, JR BF Blair, JP Nichols, T Burns, D Curnutt, JR TI Civilian Response to Active Shooter Events SO ACTIVE SHOOTER: EVENTS AND RESPONSE LA English DT Article; Book Chapter C1 [Blair, J. Pete] Texas State Univ, Criminal Justice, San Marcos, TX 78666 USA. [Blair, J. Pete] ALERRT, Res, San Marcos, TX USA. [Nichols, Terry] Texas State Univ San Marcos, ALERRT Ctr, San Marcos, TX USA. [Nichols, Terry] San Marcos Police Dept, San Marcos, TX USA. [Burns, David] US Army, Airborne Div 82, Washington, DC USA. [Curnutt, John R.] ALERRT, Training, San Marcos, TX USA. [Curnutt, John R.] Patrol Div, Kansas City, MO USA. RP Blair, JP (reprint author), Texas State Univ, Criminal Justice, San Marcos, TX 78666 USA. NR 14 TC 0 Z9 0 U1 0 U2 0 PU CRC PRESS-TAYLOR & FRANCIS GROUP PI BOCA RATON PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA BN 978-1-4665-1231-3; 978-1-4665-1229-0 PY 2013 BP 173 EP 200 D2 10.1201/b14996 PG 28 WC Criminology & Penology SC Criminology & Penology GA BC2ZK UT WOS:000351464200009 ER PT B AU Elliott, LR Redden, ES Schmeisser, ET Rupert, A AF Elliott, Linda R. Redden, Elizabeth S. Schmeisser, Elmar T. Rupert, Angus BE Ji, YG TI Tactical Scenarios for User-based Performance Evaluations SO ADVANCES IN AFFECTIVE AND PLEASURABLE DESIGN SE Advances in Human Factors and Ergonomics Series LA English DT Article; Book Chapter DE Cognitive task analysis; Multisensory systems; Scenario validation AB While laboratory-based experiments are critical to research, development of new systems also requires context-driven evaluation of technology to assure generalizability to realistic operator task demands. The capture of Soldier performance demands is particularly challenging in this regard, as many factors converge to impact performance "in the wild", such as interactions with other soldiers also performing operational tasks, tactical conditions and additional workload that is multifaceted, dynamic, and often uncertain and stressful. Thus, equipment or principles that work well in laboratory conditions need follow-up evaluations within controlled scenario-based situations that have critical characteristics of core work demands. Scenarios having well-defined boundary conditions (e.g., realistic and well articulated task demands, user experience, etc.) thus yield assessments of performance and operational relevance that are arguably valid. This report describes issues and outcomes related to development of scenarios and measures for the assessment of devices for dismount soldier teams. Procedures and results are discussed within the context of cognitive task analytic techniques C1 [Elliott, Linda R.; Redden, Elizabeth S.] US Army Res Lab, Human Engn & Res Directorate, Ft Benning, GA 31905 USA. [Schmeisser, Elmar T.] US Army Res Off, LS Neurosci, Res Triangle Pk, NC USA. [Rupert, Angus] US Army Aeromed Res Lab, Ft Rucker, AL USA. RP Elliott, LR (reprint author), US Army Res Lab, Human Engn & Res Directorate, Ft Benning, GA 31905 USA. NR 6 TC 0 Z9 0 U1 0 U2 0 PU CRC PRESS-TAYLOR & FRANCIS GROUP PI BOCA RATON PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA BN 978-1-4398-7119-5; 978-1-4398-7118-8 J9 ADV HUM FACT ERG SER JI ADV. HUMAN FACT. ERG. SER PY 2013 BP 574 EP 581 PG 8 WC Ergonomics SC Engineering GA BC2WE UT WOS:000351390700063 ER PT B AU Naylor, JT Kaber, DB Kim, SH Gil, GH Pankok, C AF Naylor, James T. Kaber, David B. Kim, Sang-Hwan Gil, Guk-Ho Pankok, Carl BE Landry, SJ TI Aviation Display Dynamics and Flight Domain in Pilot Perceptions of Display Clutter SO ADVANCES IN HUMAN ASPECTS OF AVIATION SE Advances in Human Factors and Ergonomics Series LA English DT Article; Book Chapter DE aviation human factors; cockpit display design; perceived clutter; pilot performance ID TARGET DETECTION AB This research involved a meta-analysis of data sets from three prior empirical studies on pilot perceptions of clutter in aviation displays. The objectives were to assess the affects of cockpit display dynamics and aviation domain (fixed vs. vertical takeoff and landing) on perceived clutter based on overall ratings and a multi-dimensional score collected during simulated flight tasks. Comparisons were made of observations on pilots with similar levels of experience within domain using displays (head-down or head-up) with similar features in similar segments of landing approach scenarios. Results revealed both display dynamics and the flight domain to be significant in perceived clutter and the need for such factors to be incorporated in models and measures of clutter. The findings also emphasize the need for designers to consider how display features influence human information processing and how specific visual characteristics of displays may lead to perceptions of clutter and potential performance problems. C1 [Naylor, James T.] US Army, Technol Applicat Program Off, Ft Eustis, VA 23604 USA. [Kaber, David B.; Gil, Guk-Ho; Pankok, Carl] N Carolina State Univ, Edwards P Fitts Dept Ind & Syst Engn, Raleigh, NC 27695 USA. [Kim, Sang-Hwan] Univ Michigan, Dept Ind & Mfg Syst Engn, Dearborn, MI 48128 USA. RP Naylor, JT (reprint author), US Army, Technol Applicat Program Off, Ft Eustis, VA 23604 USA. NR 13 TC 0 Z9 0 U1 1 U2 1 PU CRC PRESS-TAYLOR & FRANCIS GROUP PI BOCA RATON PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA BN 978-1-4398-7117-1; 978-1-4398-7116-4 J9 ADV HUM FACT ERG SER JI ADV. HUMAN FACT. ERG. SER PY 2013 BP 43 EP 52 PG 10 WC Ergonomics; Transportation Science & Technology SC Engineering; Transportation GA BC3OY UT WOS:000351775400006 ER PT B AU Jansen, C Elliott, LR van Breda, L Redden, ES Barnes, M AF Jansen, Chris Elliott, Linda R. van Breda, Leo Redden, Elizabeth S. Barnes, Michael BE Stanton, NA TI Remote Target Detection Using an Unmanned Vehicle: Contribution of Telepresence Features SO ADVANCES IN HUMAN ASPECTS OF ROAD AND RAIL TRANSPORTATION SE Advances in Human Factors and Ergonomics Series LA English DT Proceedings Paper CT 4th International Conference on Applied Human Factors and Ergonomics (AHFE) CY JUL 21-25, 2012 CL San Francisco, CA DE Telepresence; Robot controller; 3-D audio; Naturalistic control AB Both audio and visual perceptions are critical for soldiers to gain situation awareness (SA) of their surroundings. However, when unmanned ground vehicles are used for reconnaissance, it has not been established whether high fidelity (i.e., stereoscopic vision and three dimensional audio) perceptions will enhance awareness and effectiveness relative to lower fidelity capabilities that are more common to existing systems. This report describes the effectiveness of robotic telepresence features that included enhanced visual and three-dimensional audio sensors, along with naturalistic head-mounted control of camera movement. Soldiers performed equivalent search and identify tasks with each controller interface. Measures included indices of performance (e.g., time, accuracy), workload (NASA-TLX), SA, and user experience. Results indicated that the integrated multisensory perception and naturalistic control provided by telepresence features contributed to better task performance and lower workload. This experiment was conducted as part of a research collaboration between the US Army Research Lab field element at Fort Benning, GA, and TNO Netherlands. C1 [Elliott, Linda R.; Redden, Elizabeth S.; Barnes, Michael] US Army, Res Lab, Human Engn & Res Directorate, Ft Benning, GA USA. [Jansen, Chris; van Breda, Leo] TNO Human Factors, Soesterberg, Netherlands. RP Jansen, C (reprint author), TNO Human Factors, Soesterberg, Netherlands. NR 8 TC 0 Z9 0 U1 0 U2 1 PU CRC PRESS-TAYLOR & FRANCIS GROUP PI BOCA RATON PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA BN 978-1-4398-7124-9; 978-1-4398-7123-2 J9 ADV HUM FACT ERG SER JI ADV. HUMAN FACT. ERG. SER PY 2013 BP 127 EP 136 PG 10 WC Engineering, Civil; Ergonomics; Transportation; Transportation Science & Technology SC Engineering; Transportation GA BD9SO UT WOS:000365217000014 ER PT J AU Bounds, SE Morris, MJ AF Bounds, S. E. Morris, M. J. TI Baseline Spirometry As A Predictor Of Positive Methacholine Challenge Testing SO AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE LA English DT Meeting Abstract C1 [Bounds, S. E.; Morris, M. J.] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER THORACIC SOC PI NEW YORK PA 25 BROADWAY, 18 FL, NEW YORK, NY 10004 USA SN 1073-449X EI 1535-4970 J9 AM J RESP CRIT CARE JI Am. J. Respir. Crit. Care Med. PY 2013 VL 187 MA A4092 PG 1 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA V45TH UT WOS:000209838400528 ER PT J AU Rubio-Palis, Y Ruiz-Lopez, F Guzman, H Sanchez, V Moreno, JE Estrada, Y Bevilacqua, M Cardenas, L Martinez, A AF Rubio-Palis, Yasmin Ruiz-Lopez, Freddy Guzman, Hernan Sanchez, Victor Moreno, Jorge E. Estrada, Yarys Bevilacqua, Mariapia Cardenas, Lya Martinez, Angela TI First record of Anopheles (Nyssorhynchus) oswaldoi B y Anopheles (Nys.) albitarsis F from the Caura river basin, Bolivar State, Venezuela SO BOLETIN DE MALARIOLOGIA Y SALUD AMBIENTAL LA Spanish DT Article DE Anopheles oswaldoi B; Anopheles albitarsis F; species complex; malaria; Venezuela AB Anopheles albitarsis F and Anopheles oswaldoi B were first recorded from collections in Sucre and Cedeno Municipalities, Bolivar State. Morphometric analysis of dark and pale spots on wing Costa and hind tarsomeres of adult females, showed that the range of variation for An. albitarsis F are within the reported ranges for An. marajoara sensu latu For An. oswaldoi B the range of variation are within the ranges reported for An. oswaldoi s.l., An. oswaldoi sensu stricto from Brazil and An. konderi. DNA mitochondrial analysis (Barcode region 658 bp) showed 3.2% of genetic divergence between An. oswaldoi B and An. oswaldoi s.s., while this divergence was 5.2% between An. albirtarsis F and An. marajoara s.s. Both these values are above the proposed limits for species delimitation. C1 [Rubio-Palis, Yasmin] Minist Poder Popular Salud, Direcc Salud Ambiental, Direcc Control Vectores, Maracay, Venezuela. [Rubio-Palis, Yasmin] Univ Carabobo, BIOMED, Maracay, Venezuela. [Ruiz-Lopez, Freddy] Walter Reed Army Inst Res, Div Entomol, Silver Spring, MD 20910 USA. [Ruiz-Lopez, Freddy] Smithsonian Inst, Natl Museum Nat Hist, Dept Entomol, Museum Support Ctr, Suitland, MD 20746 USA. [Guzman, Hernan; Sanchez, Victor; Moreno, Jorge E.; Estrada, Yarys] Ctr Invest Campo Dr Francesco Vitanza, Serv Autonomo Inst Altos Estudios Dr Arnoldo Gaba, Tumeremo, Estado Bolivar, Venezuela. [Bevilacqua, Mariapia; Cardenas, Lya] Asociac Venezolana Conservac Areas Nat ACOANA, Caracas, Venezuela. [Martinez, Angela] Inst Salud Publ Estado Bolivar, Ciudad Bolivar, Venezuela. RP Rubio-Palis, Y (reprint author), Minist Poder Popular Salud, Direcc Salud Ambiental, Direcc Control Vectores, Maracay, Venezuela. EM rubiopalis@gmail.com NR 0 TC 3 Z9 3 U1 0 U2 0 PU INST ALTOS ESTUDIOS, DR ARNOLDO GABOLDON PI MARACAY PA APARTADO POSTAL 2442, MARACAY, ZP 2101, VENEZUELA SN 1690-4648 J9 B MALARIOL SALUD AMB JI Bol. Malar. Salud. Ambient. PD JAN-JUL PY 2013 VL 53 IS 1 BP 68 EP 72 PG 5 WC Infectious Diseases; Parasitology SC Infectious Diseases; Parasitology GA 268HW UT WOS:000328162000009 ER PT B AU McLaughlin, G Caraballo, V AF McLaughlin, Greg Caraballo, Vinny BA McLaughlin, G Caraballo, V BF McLaughlin, G Caraballo, V TI The Innovation Conundrum SO CHANCE OR CHOICE: UNLOCKING INNOVATION SUCCESS LA English DT Article; Book Chapter C1 [McLaughlin, Greg] Global Targeting Inc, Res & Dev, Boca Raton, FL USA. [McLaughlin, Greg] Reynolds Met Co, New York, NY USA. [McLaughlin, Greg] Inthesis Inc, New York, NY USA. [McLaughlin, Greg] ADT Secur Syst, New York, NY USA. [McLaughlin, Greg] Nova SE Univ, Ft Lauderdale, FL 33314 USA. [Caraballo, Vinny] Global Targeting Inc, New York, NY USA. [Caraballo, Vinny] US Army, New York, NY USA. RP McLaughlin, G (reprint author), Global Targeting Inc, Res & Dev, Boca Raton, FL USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU CRC PRESS-TAYLOR & FRANCIS GROUP PI BOCA RATON PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA BN 978-1-4665-8187-6; 978-1-4665-8186-9 PY 2013 BP 1 EP 13 D2 10.1201/b13921 PG 13 WC Business; Management SC Business & Economics GA BC9BI UT WOS:000356269100002 ER PT B AU McLaughlin, G Caraballo, V AF McLaughlin, Greg Caraballo, Vinny BA McLaughlin, G Caraballo, V BF McLaughlin, G Caraballo, V TI CHANCE or CHOICE Unlocking Innovation Success Preface SO CHANCE OR CHOICE: UNLOCKING INNOVATION SUCCESS LA English DT Editorial Material; Book Chapter C1 [McLaughlin, Greg] Global Targeting Inc, Res & Dev, Boca Raton, FL USA. [McLaughlin, Greg] Reynolds Met Co, New York, NY USA. [McLaughlin, Greg] Inthesis Inc, New York, NY USA. [McLaughlin, Greg] ADT Secur Syst, New York, NY USA. [McLaughlin, Greg] Nova SE Univ, Ft Lauderdale, FL 33314 USA. [Caraballo, Vinny] Global Targeting Inc, New York, NY USA. [Caraballo, Vinny] US Army, New York, NY USA. RP McLaughlin, G (reprint author), Global Targeting Inc, Res & Dev, Boca Raton, FL USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU CRC PRESS-TAYLOR & FRANCIS GROUP PI BOCA RATON PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA BN 978-1-4665-8187-6; 978-1-4665-8186-9 PY 2013 BP XIII EP + D2 10.1201/b13921 PG 8 WC Business; Management SC Business & Economics GA BC9BI UT WOS:000356269100001 ER PT B AU McLaughlin, G Caraballo, V AF McLaughlin, Greg Caraballo, Vinny BA McLaughlin, G Caraballo, V BF McLaughlin, G Caraballo, V TI Individuals and Innovation SO CHANCE OR CHOICE: UNLOCKING INNOVATION SUCCESS LA English DT Article; Book Chapter C1 [McLaughlin, Greg] Global Targeting Inc, Res & Dev, Boca Raton, FL USA. [McLaughlin, Greg] Reynolds Met Co, New York, NY USA. [McLaughlin, Greg] Inthesis Inc, New York, NY USA. [McLaughlin, Greg] ADT Secur Syst, New York, NY USA. [McLaughlin, Greg] Nova SE Univ, Ft Lauderdale, FL 33314 USA. [Caraballo, Vinny] Global Targeting Inc, New York, NY USA. [Caraballo, Vinny] US Army, New York, NY USA. RP McLaughlin, G (reprint author), Global Targeting Inc, Res & Dev, Boca Raton, FL USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU CRC PRESS-TAYLOR & FRANCIS GROUP PI BOCA RATON PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA BN 978-1-4665-8187-6; 978-1-4665-8186-9 PY 2013 BP 15 EP 25 D2 10.1201/b13921 PG 11 WC Business; Management SC Business & Economics GA BC9BI UT WOS:000356269100003 ER PT B AU McLaughlin, G Caraballo, V AF McLaughlin, Greg Caraballo, Vinny BA McLaughlin, G Caraballo, V BF McLaughlin, G Caraballo, V TI The Innovation Business Ecosystem SO CHANCE OR CHOICE: UNLOCKING INNOVATION SUCCESS LA English DT Article; Book Chapter C1 [McLaughlin, Greg] Global Targeting Inc, Res & Dev, Boca Raton, FL USA. [McLaughlin, Greg] Reynolds Met Co, New York, NY USA. [McLaughlin, Greg] Inthesis Inc, New York, NY USA. [McLaughlin, Greg] ADT Secur Syst, New York, NY USA. [McLaughlin, Greg] Nova SE Univ, Ft Lauderdale, FL 33314 USA. [Caraballo, Vinny] Global Targeting Inc, New York, NY USA. [Caraballo, Vinny] US Army, New York, NY USA. RP McLaughlin, G (reprint author), Global Targeting Inc, Res & Dev, Boca Raton, FL USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU CRC PRESS-TAYLOR & FRANCIS GROUP PI BOCA RATON PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA BN 978-1-4665-8187-6; 978-1-4665-8186-9 PY 2013 BP 27 EP 38 D2 10.1201/b13921 PG 12 WC Business; Management SC Business & Economics GA BC9BI UT WOS:000356269100004 ER PT B AU McLaughlin, G Caraballo, V AF McLaughlin, Greg Caraballo, Vinny BA McLaughlin, G Caraballo, V BF McLaughlin, G Caraballo, V TI ENOVALE (R) Solutions SO CHANCE OR CHOICE: UNLOCKING INNOVATION SUCCESS LA English DT Article; Book Chapter C1 [McLaughlin, Greg] Global Targeting Inc, Res & Dev, Boca Raton, FL USA. [McLaughlin, Greg] Reynolds Met Co, New York, NY USA. [McLaughlin, Greg] Inthesis Inc, New York, NY USA. [McLaughlin, Greg] ADT Secur Syst, New York, NY USA. [McLaughlin, Greg] Nova SE Univ, Ft Lauderdale, FL 33314 USA. [Caraballo, Vinny] Global Targeting Inc, New York, NY USA. [Caraballo, Vinny] US Army, New York, NY USA. RP McLaughlin, G (reprint author), Global Targeting Inc, Res & Dev, Boca Raton, FL USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU CRC PRESS-TAYLOR & FRANCIS GROUP PI BOCA RATON PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA BN 978-1-4665-8187-6; 978-1-4665-8186-9 PY 2013 BP 39 EP 45 D2 10.1201/b13921 PG 7 WC Business; Management SC Business & Economics GA BC9BI UT WOS:000356269100005 ER PT B AU McLaughlin, G Caraballo, V AF McLaughlin, Greg Caraballo, Vinny BA McLaughlin, G Caraballo, V BF McLaughlin, G Caraballo, V TI "E" Envision the Need SO CHANCE OR CHOICE: UNLOCKING INNOVATION SUCCESS LA English DT Article; Book Chapter C1 [McLaughlin, Greg] Global Targeting Inc, Res & Dev, Boca Raton, FL USA. [McLaughlin, Greg] Reynolds Met Co, New York, NY USA. [McLaughlin, Greg] Inthesis Inc, New York, NY USA. [McLaughlin, Greg] ADT Secur Syst, New York, NY USA. [McLaughlin, Greg] Nova SE Univ, Ft Lauderdale, FL 33314 USA. [Caraballo, Vinny] Global Targeting Inc, New York, NY USA. [Caraballo, Vinny] US Army, New York, NY USA. RP McLaughlin, G (reprint author), Global Targeting Inc, Res & Dev, Boca Raton, FL USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU CRC PRESS-TAYLOR & FRANCIS GROUP PI BOCA RATON PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA BN 978-1-4665-8187-6; 978-1-4665-8186-9 PY 2013 BP 47 EP 66 D2 10.1201/b13921 PG 20 WC Business; Management SC Business & Economics GA BC9BI UT WOS:000356269100006 ER PT B AU McLaughlin, G Caraballo, V AF McLaughlin, Greg Caraballo, Vinny BA McLaughlin, G Caraballo, V BF McLaughlin, G Caraballo, V TI "N" Nominate SO CHANCE OR CHOICE: UNLOCKING INNOVATION SUCCESS LA English DT Article; Book Chapter C1 [McLaughlin, Greg] Global Targeting Inc, Res & Dev, Boca Raton, FL USA. [McLaughlin, Greg] Reynolds Met Co, New York, NY USA. [McLaughlin, Greg] Inthesis Inc, New York, NY USA. [McLaughlin, Greg] ADT Secur Syst, New York, NY USA. [McLaughlin, Greg] Nova SE Univ, Ft Lauderdale, FL 33314 USA. [Caraballo, Vinny] Global Targeting Inc, New York, NY USA. [Caraballo, Vinny] US Army, New York, NY USA. RP McLaughlin, G (reprint author), Global Targeting Inc, Res & Dev, Boca Raton, FL USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU CRC PRESS-TAYLOR & FRANCIS GROUP PI BOCA RATON PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA BN 978-1-4665-8187-6; 978-1-4665-8186-9 PY 2013 BP 67 EP 88 D2 10.1201/b13921 PG 22 WC Business; Management SC Business & Economics GA BC9BI UT WOS:000356269100007 ER PT B AU McLaughlin, G Caraballo, V AF McLaughlin, Greg Caraballo, Vinny BA McLaughlin, G Caraballo, V BF McLaughlin, G Caraballo, V TI "O" Objectify SO CHANCE OR CHOICE: UNLOCKING INNOVATION SUCCESS LA English DT Article; Book Chapter C1 [McLaughlin, Greg] Global Targeting Inc, Res & Dev, Boca Raton, FL USA. [McLaughlin, Greg] Reynolds Met Co, New York, NY USA. [McLaughlin, Greg] Inthesis Inc, New York, NY USA. [McLaughlin, Greg] ADT Secur Syst, New York, NY USA. [McLaughlin, Greg] Nova SE Univ, Ft Lauderdale, FL 33314 USA. [Caraballo, Vinny] Global Targeting Inc, New York, NY USA. [Caraballo, Vinny] US Army, New York, NY USA. RP McLaughlin, G (reprint author), Global Targeting Inc, Res & Dev, Boca Raton, FL USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU CRC PRESS-TAYLOR & FRANCIS GROUP PI BOCA RATON PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA BN 978-1-4665-8187-6; 978-1-4665-8186-9 PY 2013 BP 89 EP 100 D2 10.1201/b13921 PG 12 WC Business; Management SC Business & Economics GA BC9BI UT WOS:000356269100008 ER PT B AU McLaughlin, G Caraballo, V AF McLaughlin, Greg Caraballo, Vinny BA McLaughlin, G Caraballo, V BF McLaughlin, G Caraballo, V TI "V" Validate SO CHANCE OR CHOICE: UNLOCKING INNOVATION SUCCESS LA English DT Article; Book Chapter C1 [McLaughlin, Greg] Global Targeting Inc, Res & Dev, Boca Raton, FL USA. [McLaughlin, Greg] Reynolds Met Co, New York, NY USA. [McLaughlin, Greg] Inthesis Inc, New York, NY USA. [McLaughlin, Greg] ADT Secur Syst, New York, NY USA. [McLaughlin, Greg] Nova SE Univ, Ft Lauderdale, FL 33314 USA. [Caraballo, Vinny] Global Targeting Inc, New York, NY USA. [Caraballo, Vinny] US Army, New York, NY USA. RP McLaughlin, G (reprint author), Global Targeting Inc, Res & Dev, Boca Raton, FL USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU CRC PRESS-TAYLOR & FRANCIS GROUP PI BOCA RATON PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA BN 978-1-4665-8187-6; 978-1-4665-8186-9 PY 2013 BP 101 EP 115 D2 10.1201/b13921 PG 15 WC Business; Management SC Business & Economics GA BC9BI UT WOS:000356269100009 ER PT B AU McLaughlin, G Caraballo, V AF McLaughlin, Greg Caraballo, Vinny BA McLaughlin, G Caraballo, V BF McLaughlin, G Caraballo, V TI "A" Align and Adapt SO CHANCE OR CHOICE: UNLOCKING INNOVATION SUCCESS LA English DT Article; Book Chapter C1 [McLaughlin, Greg] Global Targeting Inc, Res & Dev, Boca Raton, FL USA. [McLaughlin, Greg] Reynolds Met Co, New York, NY USA. [McLaughlin, Greg] Inthesis Inc, New York, NY USA. [McLaughlin, Greg] ADT Secur Syst, New York, NY USA. [McLaughlin, Greg] Nova SE Univ, Ft Lauderdale, FL 33314 USA. [Caraballo, Vinny] Global Targeting Inc, New York, NY USA. [Caraballo, Vinny] US Army, New York, NY USA. RP McLaughlin, G (reprint author), Global Targeting Inc, Res & Dev, Boca Raton, FL USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU CRC PRESS-TAYLOR & FRANCIS GROUP PI BOCA RATON PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA BN 978-1-4665-8187-6; 978-1-4665-8186-9 PY 2013 BP 117 EP 132 D2 10.1201/b13921 PG 16 WC Business; Management SC Business & Economics GA BC9BI UT WOS:000356269100010 ER PT B AU McLaughlin, G Caraballo, V AF McLaughlin, Greg Caraballo, Vinny BA McLaughlin, G Caraballo, V BF McLaughlin, G Caraballo, V TI "L" Link to Performance SO CHANCE OR CHOICE: UNLOCKING INNOVATION SUCCESS LA English DT Article; Book Chapter C1 [McLaughlin, Greg] Global Targeting Inc, Res & Dev, Boca Raton, FL USA. [McLaughlin, Greg] Reynolds Met Co, New York, NY USA. [McLaughlin, Greg] Inthesis Inc, New York, NY USA. [McLaughlin, Greg] ADT Secur Syst, New York, NY USA. [McLaughlin, Greg] Nova SE Univ, Ft Lauderdale, FL 33314 USA. [Caraballo, Vinny] Global Targeting Inc, New York, NY USA. [Caraballo, Vinny] US Army, New York, NY USA. RP McLaughlin, G (reprint author), Global Targeting Inc, Res & Dev, Boca Raton, FL USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU CRC PRESS-TAYLOR & FRANCIS GROUP PI BOCA RATON PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA BN 978-1-4665-8187-6; 978-1-4665-8186-9 PY 2013 BP 133 EP 141 D2 10.1201/b13921 PG 9 WC Business; Management SC Business & Economics GA BC9BI UT WOS:000356269100011 ER PT B AU McLaughlin, G Caraballo, V AF McLaughlin, Greg Caraballo, Vinny BA McLaughlin, G Caraballo, V BF McLaughlin, G Caraballo, V TI "E" Execute the Project SO CHANCE OR CHOICE: UNLOCKING INNOVATION SUCCESS LA English DT Article; Book Chapter C1 [McLaughlin, Greg] Global Targeting Inc, Res & Dev, Boca Raton, FL USA. [McLaughlin, Greg] Reynolds Met Co, New York, NY USA. [McLaughlin, Greg] Inthesis Inc, New York, NY USA. [McLaughlin, Greg] ADT Secur Syst, New York, NY USA. [McLaughlin, Greg] Nova SE Univ, Ft Lauderdale, FL 33314 USA. [Caraballo, Vinny] Global Targeting Inc, New York, NY USA. [Caraballo, Vinny] US Army, New York, NY USA. RP McLaughlin, G (reprint author), Global Targeting Inc, Res & Dev, Boca Raton, FL USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU CRC PRESS-TAYLOR & FRANCIS GROUP PI BOCA RATON PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA BN 978-1-4665-8187-6; 978-1-4665-8186-9 PY 2013 BP 143 EP 149 D2 10.1201/b13921 PG 7 WC Business; Management SC Business & Economics GA BC9BI UT WOS:000356269100012 ER PT B AU McLaughlin, G Caraballo, V AF McLaughlin, Greg Caraballo, Vinny BA McLaughlin, G Caraballo, V BF McLaughlin, G Caraballo, V TI ENOVALE (R) Strategies-Seven Steps for Innovation Project Success SO CHANCE OR CHOICE: UNLOCKING INNOVATION SUCCESS LA English DT Article; Book Chapter C1 [McLaughlin, Greg] Global Targeting Inc, Res & Dev, Boca Raton, FL USA. [McLaughlin, Greg] Reynolds Met Co, New York, NY USA. [McLaughlin, Greg] Inthesis Inc, New York, NY USA. [McLaughlin, Greg] ADT Secur Syst, New York, NY USA. [McLaughlin, Greg] Nova SE Univ, Ft Lauderdale, FL 33314 USA. [Caraballo, Vinny] Global Targeting Inc, New York, NY USA. [Caraballo, Vinny] US Army, New York, NY USA. RP McLaughlin, G (reprint author), Global Targeting Inc, Res & Dev, Boca Raton, FL USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU CRC PRESS-TAYLOR & FRANCIS GROUP PI BOCA RATON PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA BN 978-1-4665-8187-6; 978-1-4665-8186-9 PY 2013 BP 151 EP 174 D2 10.1201/b13921 PG 24 WC Business; Management SC Business & Economics GA BC9BI UT WOS:000356269100013 ER PT B AU McLaughlin, G Caraballo, V AF McLaughlin, Greg Caraballo, Vinny BA McLaughlin, G Caraballo, V BF McLaughlin, G Caraballo, V TI Achieving Success SO CHANCE OR CHOICE: UNLOCKING INNOVATION SUCCESS LA English DT Article; Book Chapter C1 [McLaughlin, Greg] Global Targeting Inc, Res & Dev, Boca Raton, FL USA. [McLaughlin, Greg] Reynolds Met Co, New York, NY USA. [McLaughlin, Greg] Inthesis Inc, New York, NY USA. [McLaughlin, Greg] ADT Secur Syst, New York, NY USA. [McLaughlin, Greg] Nova SE Univ, Ft Lauderdale, FL 33314 USA. [Caraballo, Vinny] Global Targeting Inc, New York, NY USA. [Caraballo, Vinny] US Army, New York, NY USA. RP McLaughlin, G (reprint author), Global Targeting Inc, Res & Dev, Boca Raton, FL USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU CRC PRESS-TAYLOR & FRANCIS GROUP PI BOCA RATON PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA BN 978-1-4665-8187-6; 978-1-4665-8186-9 PY 2013 BP 175 EP 182 D2 10.1201/b13921 PG 8 WC Business; Management SC Business & Economics GA BC9BI UT WOS:000356269100014 ER PT S AU Hughbank, RJ Horn, LC AF Hughbank, Richard J. Horn, Leland C. BE Normore, AH Erbe, N TI TRAITS AND BEHAVIOR: PSYCHOLOGICAL APPROACHES TO LEADERSHIP SO COLLECTIVE EFFICACY: INTERDISCIPLINARY PERSPECTIVES ON INTERNATIONAL LEADERSHIP SE Advances in Educational Administration LA English DT Article; Book Chapter ID POSITIVE ORGANIZATIONAL-BEHAVIOR; TRANSFORMATIONAL LEADERSHIP; AUTHENTIC LEADERSHIP; CHARISMATIC LEADERSHIP; PERFORMANCE; PERSPECTIVE; EMPOWERMENT AB The concept of leadership is an oft-discussed issue among practitioners and scholars alike without regard to culture, background, or organizational affiliation. Based on our international experiences, leadership is an art that is traditionally taught as a science which is impacted via various psychological concepts. It is both a natural phenomenon and a learned attribute that is planted, nurtured, developed, and tested over time. Certain leadership approaches are formal, only succeeding in formal settings and environments while others are dependent upon conditioning of the leader. Regardless of one's leadership style and characteristics, it is critical that both leaders and followers define and understand the variances between failure and success within an organization. This chapter addresses international leadership styles and the psychological theories that support differing approaches assisting the reader to more clearly understand and identify the subtle differences in the development of a successful leader and organization from global perspectives. C1 [Hughbank, Richard J.] US Army War Coll, Ctr Strateg Leadership, Homeland Def & Secur Issues Grp, Carlisle, PA 17013 USA. [Hughbank, Richard J.] Northwestern State Univ Louisiana, St Natchitoches, LA USA. [Horn, Leland C.] Colorado Tech Univ, Colorado Springs, CO USA. [Horn, Leland C.] Boeing Co, Dallas, TX USA. RP Hughbank, RJ (reprint author), US Army War Coll, Ctr Strateg Leadership, Homeland Def & Secur Issues Grp, Carlisle, PA 17013 USA. NR 48 TC 0 Z9 0 U1 0 U2 4 PU EMERALD GROUP PUBLISHING LTD PI BINGLEY PA HOWARD HOUSE, WAGON LANE, BINGLEY, W YORKSHIRE BD16 1WA, ENGLAND SN 1479-3660 BN 978-1-78190-681-1; 978-1-78190-680-4 J9 ADV EDUC AD PY 2013 VL 20 BP 245 EP 260 DI 10.1108/S1479-3660(2013)0000020014 PG 16 WC Education & Educational Research SC Education & Educational Research GA BD1SJ UT WOS:000358319200017 ER PT B AU Folckemer, GD AF Folckemer, Gary D. BE Dunlap, ES TI Scalable Approach to School Security SO COMPREHENSIVE HANDBOOK OF SCHOOL SAFETY SE Occupational Safety and Health Guide Series LA English DT Article; Book Chapter ID PREVENTION; VIOLENCE C1 [Folckemer, Gary D.] Eastern Kentucky Univ, Div Publ Safety, Richmond, KY 40475 USA. [Folckemer, Gary D.] US Army, Jamaica, VT 05343 USA. [Folckemer, Gary D.] Ritz Carlton Hotel Co, Chevy Chase, MD USA. [Folckemer, Gary D.] Correct Corp Amer, Nashville, TN USA. [Folckemer, Gary D.] Amer Univ, Washington, DC 20016 USA. [Folckemer, Gary D.] Eastern Kentucky Univ, Richmond, KY 40475 USA. RP Folckemer, GD (reprint author), Eastern Kentucky Univ, Div Publ Safety, Richmond, KY 40475 USA. NR 14 TC 0 Z9 0 U1 0 U2 0 PU CRC PRESS-TAYLOR & FRANCIS GROUP PI BOCA RATON PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA BN 978-1-4398-7408-0; 978-1-4398-7407-3 J9 OCCUP SAF HEALTH GUI PY 2013 BP 95 EP 107 PG 13 WC Education & Educational Research; Public, Environmental & Occupational Health SC Education & Educational Research; Public, Environmental & Occupational Health GA BC4ZK UT WOS:000353062100010 ER PT J AU Klosky, JL Klosky, WE AF Klosky, J. Ledlie Klosky, Wynn E. TI Men of action: French influence and the founding of American civil and military engineering SO CONSTRUCTION HISTORY-INTERNATIONAL JOURNAL OF THE CONSTRUCTION HISTORY SOCIETY LA English DT Article DE Civil Engineering; Military Engineering; Fortifications; Engineering Education; Technology Transfer; French-American Relations; American Revolution AB It is difficult to overstate the debt owed by the Continental Army to the French military engineers, largely volunteers, who provided essential support during a pivotal period in history. Equally important is the influence of the French scientific approach during the growth of American engineering practice in the early 19th century. Influential engineers and educators such as Duportail, Crozet, and Mahan were educated in French schools, and the methods they learned played an important role in early American engineering and construction practice. The resulting union of the French scientific theory, British methodology, and American need resulted in a unique combination of immigrant and home-grown engineers building the new nation. The authors trace the beginnings of formal engineering practice and military construction in the United States from the coming of the French engineers to the establishment of the Army Corps of Engineers and West Point; the likely source of General Putnam's fortifications at Boston and the relationship between Duportail and Kosciuszko are also mentioned. Early American engineers and professors are discussed, as is the strong connection between French and American engineering education in the early 19th century. The capstone to the early growth of engineering as a discipline in the United States came with the founding of the American Society of Civil Engineers in 1852.(1) C1 [Klosky, J. Ledlie] US Mil Acad, Civil Engn, West Point, NY 10996 USA. RP Klosky, JL (reprint author), US Mil Acad, DCME, Mahan Hall, West Point, NY 10996 USA. EM Ledlie.Klosky@usma.edu NR 39 TC 0 Z9 0 U1 0 U2 0 PU CONSTRUCTION HISTORY SOC PI CAMBRIDGE PA C/O DEPT ARCHITECTURE, CAMBRIDGE UNIV, 1-5 SCROOPE TERRACE, CAMBRIDGE, CB1 1PX, ENGLAND SN 0267-7768 J9 CONSTR HIST JI Constr. Hist. PY 2013 VL 28 IS 3 BP 69 EP 87 PG 19 WC Architecture; History SC Architecture; History GA V41CQ UT WOS:000209524700006 ER PT B AU Broome, BD AF Broome, Barbara D. BE Hall, DL Chong, CY Llinas, J Liggins, M TI Distributed Data Fusion for Network-Centric Operations Foreword SO DISTRIBUTED DATA FUSION FOR NETWORK-CENTRIC OPERATIONS LA English DT Editorial Material; Book Chapter C1 US Army Res Lab, Informat Sci Div, Adelphi Lab Ctr, Adelphi, MD 20783 USA. RP Broome, BD (reprint author), US Army Res Lab, Informat Sci Div, Adelphi Lab Ctr, Adelphi, MD 20783 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU CRC PRESS-TAYLOR & FRANCIS GROUP PI BOCA RATON PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA BN 978-1-4398-6033-5; 978-1-4398-5830-1 PY 2013 BP IX EP XI PG 3 WC Computer Science, Information Systems; Computer Science, Theory & Methods; Engineering, Electrical & Electronic SC Computer Science; Engineering GA BC5CQ UT WOS:000353169100001 ER PT S AU Kiang, RK Soebiyanto, RP Grieco, JP Achee, NL Harrington, LC Reisen, WK Anyamba, A Linthicum, KJ Pinzon, JE Zollner, G Collacicco-Mayhugh, MG AF Kiang, R. K. Soebiyanto, R. P. Grieco, J. P. Achee, N. L. Harrington, L. C. Reisen, W. K. Anyamba, A. Linthicum, K. J. Pinzon, J. E. Zollner, G. Collacicco-Mayhugh, M. G. BE Morain, SA Budge, AM TI Vector-borne infectious diseases and influenza SO ENVIRONMENTAL TRACKING FOR PUBLIC HEALTH SURVEILLANCE SE International Society for Photogrammetry and Remote Sensing (ISPRS) Book Series LA English DT Article; Book Chapter ID RIFT-VALLEY FEVER; AEDES-AEGYPTI DIPTERA; WEST-NILE-VIRUS; EQUINE ENCEPHALOMYELITIS VIRUS; CULICIDAE LARVAL HABITATS; ST-LOUIS ENCEPHALITIS; AMERICAN CUTANEOUS LEISHMANIASIS; GEOGRAPHIC INFORMATION-SYSTEMS; SOUTHWESTERN UNITED-STATES; NINO SOUTHERN-OSCILLATION AB Breeding, propagation and survivorship of disease-transmitting arthropod vectors often depend on meteorological and environmental parameters. Statistical and biological modelling that incorporate satellite-acquired data provide useful tools for assessing and forecasting these diseases, assessing possible outbreak areas and providing vital information for policies and decision making. C1 [Kiang, R. K.; Soebiyanto, R. P.; Anyamba, A.; Pinzon, J. E.] NASA, Goddard Space Flight Ctr, Greenbelt, MD 20771 USA. [Soebiyanto, R. P.; Anyamba, A.] Univ Space Res Assoc, Columbia, MD 21044 USA. [Grieco, J. P.; Achee, N. L.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [Harrington, L. C.] Cornell Univ, Ithaca, NY 14853 USA. [Reisen, W. K.] Univ Calif Davis, Sch Vet Med, Davis, CA 95616 USA. [Linthicum, K. J.] ARS, USDA, Gainesville, FL 32608 USA. [Pinzon, J. E.] Sci Syst & Applicat Inc, Lanham, MD 20706 USA. [Zollner, G.] Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. [Collacicco-Mayhugh, M. G.] Walter Reed Army Inst Res, Div Entomol, Silver Spring, MD 20910 USA. RP Kiang, RK (reprint author), NASA, Goddard Space Flight Ctr, Greenbelt, MD 20771 USA. EM richard.kiang@nasa.gov; radina.p.soebiyanto@nasa.gov; jgrieco@usuhs.mil; nachee@usuhs.mil; lch27@cornell.edu; wkreisen@ucdavis.edu; assaf.anyamba@nasa.gov; kenneth.linthicum@ars.usda.gov; jorge.e.pinzon@nasa.gov; gabriela.zollner@us.army.mil; Michelle.Colacicco@us.army.mil NR 317 TC 0 Z9 0 U1 0 U2 0 PU A A BALKEMA PUBLISHERS PI LEIDEN PA SCHIPHOLWEG 107C, PO BOX 447, 2316 XC LEIDEN, NETHERLANDS SN 1572-3348 BN 978-0-203-09327-6; 978-0-415-58471-5 J9 ISPRS BOOK SER PY 2013 VL 11 BP 21 EP 86 PG 66 WC Public, Environmental & Occupational Health; Remote Sensing SC Public, Environmental & Occupational Health; Remote Sensing GA BC2MZ UT WOS:000351090700004 ER PT S AU Witt, CJ Pinzon, JE Manibusan, PA Pavlin, JA Gibbons, RV Myers, TE Richards, AL Daszak, P Luby, SP Epstein, JH Hossain, MJ Gurley, ES Pulliam, JRC Zayed, A Abdel-Dayem, MS Collacicco-Mayhugh, MG AF Witt, C. J. Pinzon, J. E. Manibusan, P. A. Pavlin, J. A. Gibbons, R. V. Myers, T. E. Richards, A. L. Daszak, P. Luby, S. P. Epstein, J. H. Hossain, M. Jahangir Gurley, E. S. Pulliam, J. R. C. Zayed, A. Abdel-Dayem, M. S. Collacicco-Mayhugh, M. G. BE Morain, SA Budge, AM TI Emerging and re-emerging diseases SO ENVIRONMENTAL TRACKING FOR PUBLIC HEALTH SURVEILLANCE SE International Society for Photogrammetry and Remote Sensing (ISPRS) Book Series LA English DT Article; Book Chapter ID EBOLA HEMORRHAGIC-FEVER; NIPAH VIRUS ENCEPHALITIS; AEDES-AEGYPTI DIPTERA; VECTOR-BORNE DISEASES; ZOONOTIC CUTANEOUS LEISHMANIASIS; NORTH-ATLANTIC OSCILLATION; ECOLOGICAL NICHE MODELS; GLOBAL CLIMATE-CHANGE; WESTERN UPPER NILE; VISCERAL LEISHMANIASIS AB This chapter examines emerging and re-emerging diseases in context of the environmental and ecological conditions, trends and events that together drive a microbe's transition pathway to that emergence. The study of these naturally occurring phenomena provides insights into possible future disease outbreak events. It also suggests possible ways to monitor for such events through targeted, proactive surveillance. Disease emergence should not come as a surprise. It should be expected, and societies should be prepared for it. C1 [Witt, C. J.] Armed Forces Hlth Surveillance Ctr, Silver Spring, MD 20910 USA. [Pinzon, J. E.] Sci Syst & Applicat Inc, Greenbelt, MD USA. [Manibusan, P. A.] Tripler Army Med Ctr, Honolulu, HI 96859 USA. [Pavlin, J. A.; Gibbons, R. V.] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Myers, T. E.] Naval Med Res Ctr, Silver Spring, MD 20910 USA. [Richards, A. L.] Naval Med Res Ctr, Silver Spring, MD USA. [Daszak, P.; Epstein, J. H.] EcoHlth Alliance, New York, NY 10001 USA. [Luby, S. P.] Bangladesh Ctr Hlth & Populat Res, Int Ctr Diarrhoeal Dis Res, Dhaka 1212, Bangladesh. [Hossain, M. Jahangir; Gurley, E. S.] Int Ctr Diarrhoeal Dis Res, Dhaka 1212, Bangladesh. [Pulliam, J. R. C.] Univ Florida, Coll Vet Med, Gainesville, FL 32610 USA. [Zayed, A.; Abdel-Dayem, M. S.] Cairo Univ, Cairo, Egypt. [Zayed, A.; Abdel-Dayem, M. S.] US Naval Med Res Unit, Cairo, Egypt. [Collacicco-Mayhugh, M. G.] Walter Reed Army Inst Res, Div Entomol, Silver Spring, MD 20910 USA. RP Witt, CJ (reprint author), Armed Forces Hlth Surveillance Ctr, Silver Spring, MD 20910 USA. EM cwitt@cdham.org; jorge.e.pinzon@nasa.gov; pedro.manibusanjr@us.army.mil; julie.pavlin@us.army.mil; robert.gibbons@afrims.org; todd.myers@med.navy.mil; allen.richards@mad.navy.mil; daszak@ecohealthalliance.org; sluby@icddrb.org; epstein@ecohealthalliance.org; jhossain@icddbr.org; egurley@icddrb.org; pulliam@ufl.edu; Alia.Zayed.eg@med.navy.mil; Mahmoud.Abdel-Dayem.eg@med.navy.mil; Michelle.Colacicco@us.army.mil RI Gurley, Emily/B-7903-2010 OI Gurley, Emily/0000-0002-8648-9403 NR 226 TC 0 Z9 0 U1 0 U2 0 PU A A BALKEMA PUBLISHERS PI LEIDEN PA SCHIPHOLWEG 107C, PO BOX 447, 2316 XC LEIDEN, NETHERLANDS SN 1572-3348 BN 978-0-203-09327-6; 978-0-415-58471-5 J9 ISPRS BOOK SER PY 2013 VL 11 BP 187 EP 226 PG 40 WC Public, Environmental & Occupational Health; Remote Sensing SC Public, Environmental & Occupational Health; Remote Sensing GA BC2MZ UT WOS:000351090700007 ER PT J AU Bergmann-Leitner, ES Hosie, H Trichilo, J DeRiso, E Ranallo, RT Alefantis, T Savranskaya, T Grewal, P Ockenhouse, CE Venkatesan, MM DelVecchio, VG Angov, E AF Bergmann-Leitner, Elke S. Hosie, Heather Trichilo, Jessica DeRiso, Elizabeth Ranallo, Ryan T. Alefantis, Timothy Savranskaya, Tatyana Grewal, Paul Ockenhouse, Christian E. Venkatesan, Malabi M. DelVecchio, Vito G. Angov, Eveline TI Self-adjuvanting bacterial vectors expressing pre-erythrocytic antigens induce sterile protection against malaria SO FRONTIERS IN IMMUNOLOGY LA English DT Article DE E. coli; Shigella; malaria; self-adjuvanting; cellular targeting; bacterial vaccine vector; CelTOS; CSP AB Genetically inactivated, Gram-negative bacteria that express malaria vaccine candidates represent a promising novel self-adjuvanting vaccine approach. Antigens expressed on particulate bacterial carriers not only target directly to antigen-presenting cells but also provide a strong danger signal thus circumventing the requirement for potent extraneous adjuvants. E. coli expressing malarial antigens resulted in the induction of either Thl or Th2 biased responses that were dependent on both antigen and sub-cellular localization. Some of these constructs induced higher quality humoral responses compared to recombinant protein and most importantly they were able to induce sterile protection against sporozoite challenge in a murine model of malaria. In light of these encouraging results, two major Plasmodium falciparum pre-erythrocytic malaria vaccine targets, the Cell-Traversal protein for Ookinetes and Sporozoites (CeITOS) fused to the Maltose-binding protein in the periplasmic space and the Circumsporozoite Protein (CSP) fused to the Outer membrane (OM) protein A in the OM were expressed in a clinically relevant, attenuated Shigella strain (Shigella flexnefi 2a). This type of live-attenuated vector has previously undergone clinical investigations as a vaccine against shigellosis. Using this novel delivery platform for malaria, we find that vaccination with the whole-organism represents an effective vaccination alternative that induces protective efficacy against sporozoite challenge. Shigella GeMI-Vax expressing malaria targets warrant further evaluation to determine their full potential as a dual disease, multivalent, self-adjuvanting vaccine system, against both shigellosis, and malaria. C1 [Bergmann-Leitner, Elke S.; Hosie, Heather; DeRiso, Elizabeth; Ockenhouse, Christian E.; Angov, Eveline] Walter Reed Army Inst Res, Malaria Vaccine Branch, Silver Spring, MD 20910 USA. [Trichilo, Jessica; Alefantis, Timothy; Grewal, Paul; DelVecchio, Vito G.] Vital Probes Inc, Mayfield, PA USA. [Ranallo, Ryan T.; Venkatesan, Malabi M.] WRAIR, Div Bacterial & Rickettsial Dis, Silver Spring, MD USA. [Savranskaya, Tatyana] WRAIR, Div Entomol, Silver Spring, MD USA. RP Angov, E (reprint author), Walter Reed Army Inst Res, Dept Mol Parasitol, Malaria Vaccine Branch, Silver Spring, MD 20910 USA. EM evelina.angov.civ@mail.mil FU United States Army Medical Research and Materiel Command through ARMY SBIR [W81XWH-10-C-0003]; ARMY In-house Laboratory Independent Research (ILIR) program FX The authors would like to thank Ms. Katharine Boyle and Ms. Elizabeth Duncan for their technical assistance on the animal studies and immunological assays, Dr. Sheetij Dutta for providing recombinant P. falciparum circumsporozoite protein used in ELISAs and Western blots. This work was supported by the United States Army Medical Research and Materiel Command through ARMY SBIR funding to Vital Probes Inc. under contract #W81XWH-10-C-0003, through the Military Infectious Diseases and Research Program (MIDRP) and the ARMY In-house Laboratory Independent Research (ILIR) program. NR 57 TC 4 Z9 4 U1 0 U2 3 PU FRONTIERS RESEARCH FOUNDATION PI LAUSANNE PA PO BOX 110, LAUSANNE, 1015, SWITZERLAND SN 1664-3224 J9 FRONT IMMUNOL JI Front. Immunol. PY 2013 VL 4 AR UNSP 176 DI 10.3389/fimmu.2013.00176 PG 15 WC Immunology SC Immunology GA V38WS UT WOS:000209374100172 PM 23847617 ER PT J AU Gupta, RK Przekwas, A AF Gupta, Raj K. Przekwas, Andrzej TI Mathematical models of blast-induced TBI: current status, challenges, and prospects SO FRONTIERS IN NEUROLOGY LA English DT Review DE traumatic brain injury; blast injury; mathematical model; biomechanics; neurobiology AB Blast-induced traumatic brain injury (TBI) has become a signature wound of recent military activities and is the leading cause of death and long-term disability among U.S. soldiers. The current limited understanding of brain injury mechanisms impedes the development of protection, diagnostic, and treatment strategies. We believe mathematical models of blast wave brain injury biomechanics and neurobiology, complemented with in vitro and in vivo experimental studies, will enable a better understanding of injury mechanisms and accelerate the development of both protective and treatment strategies. The goal of this paper is to review the current state of the art in mathematical and computational modeling of blast-induced TBI, identify research gaps, and recommend future developments. A brief overview of blast wave physics, injury biomechanics, and the neurobiology of brain injury is used as a foundation for a more detailed discussion of multiscale mathematical models of primary biomechanics and secondary injury and repair mechanisms. The paper also presents a discussion of model development strategies, experimental approaches to generate benchmark data for model validation, and potential applications of the model for prevention and protection against blast wave TBI. C1 [Gupta, Raj K.] US Army Med Res & Mat Command, Coordinating Off, Dept Def, Blast Injury Res Program, 504 Scott St, Ft Detrick, MD USA. [Przekwas, Andrzej] CFD Res Corp, Computat Med & Biol Div, Huntsville, AL USA. RP Gupta, RK (reprint author), US Army Med Res & Mat Command, Coordinating Off, Dept Def, Blast Injury Res Program, 504 Scott St, Ft Detrick, MD USA. EM raj.gupta@us.army.mil; ajp@cfdrc.com NR 232 TC 19 Z9 19 U1 3 U2 14 PU FRONTIERS MEDIA SA PI LAUSANNE PA PO BOX 110, EPFL INNOVATION PARK, BUILDING I, LAUSANNE, 1015, SWITZERLAND SN 1664-2295 J9 FRONT NEUROL JI Front. Neurol. PY 2013 VL 4 AR 59 DI 10.3389/fneur.2013.00059 PG 21 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA V42QT UT WOS:000209629000058 PM 23755039 ER PT J AU Shear, DA Tortella, FC AF Shear, Deborah A. Tortella, Frank C. TI A military-centered approach to neuroprotection for traumatic brain injury SO FRONTIERS IN NEUROLOGY LA English DT Review DE TBI biomarkers; combination drug therapy; isobolographic; pre-clinical; neuroprotective agents AB Studies in animals show that many compounds and therapeutics have the potential to greatly reduce the morbidity and post-injury clinical sequela for soldiers experiencing TBI. However, to date there are no FDA approved drugs for the treatment of TBI. In fact, expert opinion suggests that combination therapies will be necessary to treat any stage of TBI recovery. Our approach to this research effort is to conduct comprehensive pre-clinical neuroprotection studies in military-relevant animal models of TBI using the most promising neuroprotective agents. In addition, emerging efforts incorporating novel treatment strategies such as stem cell based therapies and alternative therapeutic approaches will be discussed. The development of a non-surgical, non-invasive brain injury therapeutic clearly addresses a major, unresolved medical problem for the Combat Casualty Care Research Program. Since drug discovery is too expensive to be pursued by DOD in the TBI arena, this effort capitalizes on partnerships with the Private Sector (Pharmaceutical Companies) and academic collaborations (Operation Brain Trauma Therapy Consortium) to study therapies already under advanced development. Candidate therapies selected for research include drugs that are aimed at reducing the acute and delayed effects of the traumatic incident, stem cell therapies aimed at brain repair, and selective brain cooling to stabilize cerebral metabolism. Each of these efforts can also focus on combination therapies targeting multiple mechanisms of neuronal injury. C1 [Shear, Deborah A.; Tortella, Frank C.] Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci, Branch Brain Trauma Neuroprotect & Neurorestorat, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. RP Shear, DA (reprint author), Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci, Branch Brain Trauma Neuroprotect & Neurorestorat, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM deborah.a.shear@us.army.mil NR 65 TC 4 Z9 4 U1 0 U2 3 PU FRONTIERS MEDIA SA PI LAUSANNE PA PO BOX 110, EPFL INNOVATION PARK, BUILDING I, LAUSANNE, 1015, SWITZERLAND SN 1664-2295 J9 FRONT NEUROL JI Front. Neurol. PY 2013 VL 4 AR 73 DI 10.3389/fneur.2013.00073 PG 6 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA V42QT UT WOS:000209629000072 PM 23781213 ER PT J AU Temme, L Bleiberg, J Reeves, D Still, DL Levinson, D Browning, R AF Temme, Leonard Bleiberg, Joseph Reeves, Dennis Still, David L. Levinson, Dan Browning, Rebecca TI Uncovering latent deficits due to mild traumatic brain injury by using normobaric hypoxia stress SO FRONTIERS IN NEUROLOGY LA English DT Article DE mild traumatic brain injury; normobaric hypoxia; cognitive stress test; concussion; BrainCheckers; automated neuropsychological assessment metrics; mTBI biomarkers; hypoxic challenge AB Memory deficits and other cognitive symptoms frequently associated with mTBI are commonly thought to resolve within 7-10 days. This generalization is based principally on observations made in individuals who are in the unstressed environmental conditions typical of a clinic and so does not consider the impact of physiologic, environmental, or psychological stress. Normobaric hypoxic stress can be generated with normal mean sea level (MSL) air, which is about 21 % oxygen (O-2) and 78% nitrogen (N), by reducing the percentage of O-2 and increasing the percentage of N so that the resultant mixed-gas has a partial pressure of O-2 approximating that of specified altitudes. This technique was used to generate normobaric hypoxic equivalents of 8,000, 12,000, and 14,000 feet above MSL in a group of 36 volunteers with a mTBI history and an equal number of controls matched on the basis of age, gender, tobacco smoking consumption, weight, height, and body mass index. Short-term visual memory was tested using the Matching to Sample (M2S) subtest of the BrainCheckers analog of the Automated Neuropsychological Assessment Metrics. Although there were no significant differences in M2S performance between the two groups of subjects at MSL, with increased altitude, the mTBI group performance was significantly worse than that of the control group. When the subjects were returned to MSL, the difference disappeared. This finding suggests that the "hypoxic challenge" paradigm developed here has potential clinical utility for assessing the effects of mTBI in individuals who appear asymptomatic under normal conditions. C1 [Temme, Leonard; Still, David L.] US Army, Aeromed Res Lab, Sensory Res Div, Vis Sci Branch, 6901 Andrews Ave,POB 620577, Ft Rucker, AL 36362 USA. [Bleiberg, Joseph] Walter Reed Natl Mil Med Ctr, Natl Intrepid Ctr Excellence, Bethesda, MD USA. [Reeves, Dennis; Browning, Rebecca] Clinvest Res, Springfield, MO USA. [Levinson, Dan] Alliant Int Univ Irvine, Calif Sch Forens Studies, Irvine, CA USA. RP Temme, L (reprint author), US Army, Aeromed Res Lab, Sensory Res Div, Vis Sci Branch, 6901 Andrews Ave,POB 620577, Ft Rucker, AL 36362 USA. EM Leonard.A.Temme.civ@mail.mil OI Bleiberg, Joseph/0000-0003-0867-5494 FU Congressionally Directed Medical Research Program TBI, PTSD Programs Award [W81XWH-08-2-0052 PTO75175] FX This research was supported in part by the Congressionally Directed Medical Research Program TBI, PTSD Programs Award Number W81XWH-08-2-0052 PTO75175: the effects hypoxia on cognitive function in aviators and complex system operators that have had a mild traumatic brain injury. NR 14 TC 4 Z9 5 U1 0 U2 1 PU FRONTIERS MEDIA SA PI LAUSANNE PA PO BOX 110, EPFL INNOVATION PARK, BUILDING I, LAUSANNE, 1015, SWITZERLAND SN 1664-2295 J9 FRONT NEUROL JI Front. Neurol. PY 2013 VL 4 AR 41 DI 10.3389/fneur.2013.00041 PG 7 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA V42QT UT WOS:000209629000040 PM 23641232 ER PT J AU Rivera, JC Strohbach, CA Wenke, JC Rathbone, CR AF Rivera, Jessica C. Strohbach, Cassandra A. Wenke, Joseph C. Rathbone, Christopher R. TI Beyond osteogenesis: an in vitro comparison of the potentials of six bone morphogenetic proteins SO FRONTIERS IN PHARMACOLOGY LA English DT Article DE bone morphogenetic protein; osteoblast; bone marrow stromal cell; osteogenesis; angiogenesis; chemotaxis ID MESENCHYMAL STEM-CELLS; HUMAN ADIPOSE-TISSUE; STROMAL CELLS; EXPRESSION; RAT; DIFFERENTIATION; REGENERATION; DELIVERY; MARROW; BMPS AB Bone morphogenetic proteins (BMPs) other than the clinically available BMP-2 and BMP-7 may be useful for improving fracture healing through both increasing osteogenesis and creating a favorable healing environment by altering cytokine release by endogenous cells. Given the spectrum of potential applications for BMPs, the objective of this study was to evaluate various BMPs under a variety of conditions to provide further insight into their therapeutic capabilities. The alkaline phosphatase (ALP) activity of both C2C12 and human adipose-derived stem cells (hASCs) was measured after exposure of increasing doses of recombinant human BMP-2, -4, -5, -6, -7, or -9 for 3 and 7 days. BMPs-2, -4, -5, -6, -7, and -9 were compared in terms of their ability to affect the release of stromal derived factor-1 (SDF-1), vascular endothelial growth factor (VEGF), and basic fibroblast growth factor (b-FGF) from human bone marrow stromal cells (hBMSCs). Gene expression of ALP osteocalcin, SDF-1, VEGF, and b-FGF following shRNA-mediated knockdown of BMP-2 and BMP-6 in hBMSCs or human osteoblasts under osteogenic differentiation conditions was also evaluated. Collectively, BMPs-6 and -9 produced the greatest osteogenic differentiation of C2C12 and hASCs as determined by ALP. The hB MSC secretion of SDF-1 was most affected by BMP-5, VEGF by BMP-4, and b-FGF by BMP-2. The knockdown of BMP-2 in BMSCs had no effect on any of the genes measured whereas BMP-6 knockdown in hBMSCs caused a significant increase in VEGF gene expression. BMP-2 and BMP-6 knockdown in human osteoblasts caused significant increases in VEGF gene expression and trends toward decreases in osteocalcin expression. These findings support efforts to study other BMPs as potential bone graft supplements, and to consider combined BMP delivery for promotion of multiple aspects of fracture healing. C1 [Rivera, Jessica C.; Strohbach, Cassandra A.; Wenke, Joseph C.; Rathbone, Christopher R.] US Army, Inst Surg Res, JBSA, Extrem Trauma & Regenerat Med, Ft Sam Houston, TX 78234 USA. RP Rivera, JC (reprint author), US Army, Inst Surg Res, JBSA, Extrem Trauma & Regenerat Med, 3698 Chambers Pass, Ft Sam Houston, TX 78234 USA. EM jessica.cross@us.army.mil FU U.S. Army Institite of Surgical Research FX The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the U.S. Army Medical Research and Materiel Command, Department of the Army or the Department of Defense. This study was supported by the U.S. Army Institite of Surgical Research. NR 30 TC 7 Z9 9 U1 1 U2 3 PU FRONTIERS RESEARCH FOUNDATION PI LAUSANNE PA PO BOX 110, LAUSANNE, 1015, SWITZERLAND SN 1663-9812 J9 FRONT PHARMACOL JI Front. Pharmacol. PY 2013 VL 4 AR 125 DI 10.3389/fphar.2013.00125 PG 7 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA AX6CS UT WOS:000347011700123 PM 24101902 ER PT B AU Sottilare, RA AF Sottilare, Robert A. BE Best, C Galanis, G Kerry, J Sottilare, R TI Training Technology: The State of Practice and Emerging Concepts SO FUNDAMENTAL ISSUES IN DEFENSE TRAINING AND SIMULATION SE Human Factors in Defence LA English DT Article; Book Chapter C1 US Army Res Lab, Human Res & Engn Directorate, Adelphi, MD 20783 USA. RP Sottilare, RA (reprint author), US Army Res Lab, Human Res & Engn Directorate, Adelphi, MD 20783 USA. OI Sottilare, Robert/0000-0002-5278-2441 NR 0 TC 0 Z9 0 U1 0 U2 0 PU ASHGATE PUBLISHING LTD PI ALDERSHOT PA GOWER HOUSE, CROFT ROAD, ALDERSHOT GU11 3HR, ENGLAND BN 978-1-4094-4722-1; 978-1-4094-4721-4 J9 HUM FACT DEFENCE PY 2013 BP 157 EP 158 PG 2 WC Social Sciences, Interdisciplinary SC Social Sciences - Other Topics GA BC4CY UT WOS:000352310800013 ER PT B AU Pettitt, MBH Norfleet, JE Pike, WY AF Pettitt, M. Beth H. Norfleet, Jack E. Pike, William Y. BE Best, C Galanis, G Kerry, J Sottilare, R TI Medical Simulation for Training SO FUNDAMENTAL ISSUES IN DEFENSE TRAINING AND SIMULATION SE Human Factors in Defence LA English DT Article; Book Chapter ID ODOR C1 [Pettitt, M. Beth H.; Norfleet, Jack E.; Pike, William Y.] US Army Res Lab, Human Res & Engn Directorate, Adelphi, MD 20783 USA. RP Pettitt, MBH (reprint author), US Army Res Lab, Human Res & Engn Directorate, Adelphi, MD 20783 USA. NR 26 TC 0 Z9 0 U1 0 U2 0 PU ASHGATE PUBLISHING LTD PI ALDERSHOT PA GOWER HOUSE, CROFT ROAD, ALDERSHOT GU11 3HR, ENGLAND BN 978-1-4094-4722-1; 978-1-4094-4721-4 J9 HUM FACT DEFENCE PY 2013 BP 193 EP 201 PG 9 WC Social Sciences, Interdisciplinary SC Social Sciences - Other Topics GA BC4CY UT WOS:000352310800017 ER PT B AU Long, RA AF Long, Rodney A. BE Best, C Galanis, G Kerry, J Sottilare, R TI Virtual Worlds and Serious Games as Training Tools SO FUNDAMENTAL ISSUES IN DEFENSE TRAINING AND SIMULATION SE Human Factors in Defence LA English DT Article; Book Chapter C1 US Army Res Lab, Human Res & Engn Directorate, Adelphi, MD 20783 USA. RP Long, RA (reprint author), US Army Res Lab, Human Res & Engn Directorate, Adelphi, MD 20783 USA. NR 19 TC 0 Z9 0 U1 0 U2 0 PU ASHGATE PUBLISHING LTD PI ALDERSHOT PA GOWER HOUSE, CROFT ROAD, ALDERSHOT GU11 3HR, ENGLAND BN 978-1-4094-4722-1; 978-1-4094-4721-4 J9 HUM FACT DEFENCE PY 2013 BP 203 EP 211 PG 9 WC Social Sciences, Interdisciplinary SC Social Sciences - Other Topics GA BC4CY UT WOS:000352310800018 ER PT B AU Sottilare, RA Goldberg, S AF Sottilare, Robert A. Goldberg, Stephen BE Best, C Galanis, G Kerry, J Sottilare, R TI Research Gaps for Adaptive Computer-Based Tutoring Systems SO FUNDAMENTAL ISSUES IN DEFENSE TRAINING AND SIMULATION SE Human Factors in Defence LA English DT Article; Book Chapter C1 [Sottilare, Robert A.] US Army Res Lab, Human Res & Engn Directorate, Adelphi, MD 20783 USA. [Goldberg, Stephen] Univ Cent Florida, Inst Simulat & Training, Orlando, FL 32816 USA. RP Sottilare, RA (reprint author), US Army Res Lab, Human Res & Engn Directorate, Adelphi, MD 20783 USA. OI Sottilare, Robert/0000-0002-5278-2441 NR 18 TC 0 Z9 0 U1 0 U2 0 PU ASHGATE PUBLISHING LTD PI ALDERSHOT PA GOWER HOUSE, CROFT ROAD, ALDERSHOT GU11 3HR, ENGLAND BN 978-1-4094-4722-1; 978-1-4094-4721-4 J9 HUM FACT DEFENCE PY 2013 BP 213 EP 222 PG 10 WC Social Sciences, Interdisciplinary SC Social Sciences - Other Topics GA BC4CY UT WOS:000352310800019 ER PT B AU Sottilare, RA Brawner, KW Goldberg, BS Holden, HK AF Sottilare, Robert A. Brawner, Keith W. Goldberg, Benjamin S. Holden, Heather K. BE Best, C Galanis, G Kerry, J Sottilare, R TI The Generalized Intelligent Framework for Tutoring (GIFT) SO FUNDAMENTAL ISSUES IN DEFENSE TRAINING AND SIMULATION SE Human Factors in Defence LA English DT Article; Book Chapter C1 [Sottilare, Robert A.; Brawner, Keith W.; Goldberg, Benjamin S.; Holden, Heather K.] US Army Res Lab, Human Res & Engn Directorate, Learning Intelligent Tutoring Environm LITE Lab, Adelphi, MD 20783 USA. RP Sottilare, RA (reprint author), US Army Res Lab, Human Res & Engn Directorate, Learning Intelligent Tutoring Environm LITE Lab, Adelphi, MD 20783 USA. OI Sottilare, Robert/0000-0002-5278-2441 NR 13 TC 4 Z9 4 U1 0 U2 1 PU ASHGATE PUBLISHING LTD PI ALDERSHOT PA GOWER HOUSE, CROFT ROAD, ALDERSHOT GU11 3HR, ENGLAND BN 978-1-4094-4722-1; 978-1-4094-4721-4 J9 HUM FACT DEFENCE PY 2013 BP 223 EP 233 PG 11 WC Social Sciences, Interdisciplinary SC Social Sciences - Other Topics GA BC4CY UT WOS:000352310800020 ER PT B AU Hart, J Gratch, J Marsella, S AF Hart, John Gratch, Jonathan Marsella, Stacy BE Best, C Galanis, G Kerry, J Sottilare, R TI How Virtual Reality Training Can Win Friends and Influence People SO FUNDAMENTAL ISSUES IN DEFENSE TRAINING AND SIMULATION SE Human Factors in Defence LA English DT Article; Book Chapter ID BEHAVIOR; HUMANS C1 [Hart, John] US Army Res Lab, Human Res & Engn Directorate, Adelphi, MD 20783 USA. [Gratch, Jonathan; Marsella, Stacy] Univ So Calif, Inst Creat Technol, Los Angeles, CA 90089 USA. RP Hart, J (reprint author), US Army Res Lab, Human Res & Engn Directorate, Adelphi, MD 20783 USA. NR 67 TC 5 Z9 5 U1 0 U2 0 PU ASHGATE PUBLISHING LTD PI ALDERSHOT PA GOWER HOUSE, CROFT ROAD, ALDERSHOT GU11 3HR, ENGLAND BN 978-1-4094-4722-1; 978-1-4094-4721-4 J9 HUM FACT DEFENCE PY 2013 BP 235 EP 249 PG 15 WC Social Sciences, Interdisciplinary SC Social Sciences - Other Topics GA BC4CY UT WOS:000352310800021 ER PT B AU Tshabalala, MA Jakes, J VanLandingham, MR Wang, SX Peltonen, J AF Tshabalala, Mandla A. Jakes, Joseph VanLandingham, Mark R. Wang, Shaoxia Peltonen, Jouko BE Rowell, RM TI Surface Characterization SO HANDBOOK OF WOOD CHEMISTRY AND WOOD COMPOSITES, 2ND EDITION LA English DT Article; Book Chapter ID INVERSE GAS-CHROMATOGRAPHY; ATOMIC-FORCE MICROSCOPY; WOOD CELL-WALLS; ION MASS-SPECTROMETRY; SCANNING-ELECTRON-MICROSCOPY; ACID-BASE PROPERTIES; MECHANICAL-PROPERTIES; ELASTIC-MODULUS; INSTRUMENTED INDENTATION; SPRUCE WOOD C1 [Tshabalala, Mandla A.; Jakes, Joseph] USDA, Forest Prod Lab, Madison, WI 53705 USA. [VanLandingham, Mark R.] Army Res Lab, Adelphi, MD USA. [Wang, Shaoxia; Peltonen, Jouko] Abo Akad Univ, Ctr Funct Mat, Turku, Finland. RP Tshabalala, MA (reprint author), USDA, Forest Prod Lab, Madison, WI 53705 USA. NR 141 TC 1 Z9 1 U1 0 U2 1 PU CRC PRESS-TAYLOR & FRANCIS GROUP PI BOCA RATON PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA BN 978-1-4398-5381-8; 978-1-4398-5380-1 PY 2013 BP 217 EP 252 PG 36 WC Materials Science, Paper & Wood; Materials Science, Composites SC Materials Science GA BC7SM UT WOS:000355191400009 ER PT J AU McDowell, K Lin, CT Oie, KS Jung, TP Gordon, S Whitaker, KW Li, SY Lu, SW Hairston, WD AF McDowell, Kaleb Lin, Chin-Teng Oie, Kelvin S. Jung, Tzyy-Ping Gordon, Stephen Whitaker, Keith W. Li, Shih-Yu Lu, Shao-Wei Hairston, W. David TI Real-World Neuroimaging Technologies SO IEEE ACCESS LA English DT Article DE Behavioral science; biomarkers; body sensor networks; brain computer interfaces; brain computer interaction; data acquisition; electroencephalography; monitoring; translational research; wearable sensors AB Decades of heavy investment in laboratory-based brain imaging and neuroscience have led to foundational insights into how humans sense, perceive, and interact with the external world. However, it is argued that fundamental differences between laboratory-based and naturalistic human behavior may exist. Thus, it remains unclear how well the current knowledge of human brain function translates into the highly dynamic real world. While some demonstrated successes in real-world neurotechnologies are observed, particularly in the area of brain-computer interaction technologies, innovations and developments to date are limited to a small science and technology community. We posit that advancements in real world neuroimaging tools for use by a broad-based workforce will dramatically enhance neurotechnology applications that have the potential to radically alter human system interactions across all aspects of everyday life. We discuss the efforts of a joint government-academic-industry team to take an integrative, interdisciplinary, and multi-aspect approach to translate current technologies into devices that are truly fieldable across a range of environments. Results from initial work, described here, show promise for dramatic advances in the field that will rapidly enhance our ability to assess brain activity in real-world scenarios. C1 [McDowell, Kaleb; Oie, Kelvin S.; Whitaker, Keith W.; Hairston, W. David] US Army Res Lab, Translat Neurosci Branch, Aberdeen Proving Ground, MD 21005 USA. [Lin, Chin-Teng; Li, Shih-Yu; Lu, Shao-Wei] Natl Chiao Tung Univ, Dept Elect Engn, Hsinchu 30010, Taiwan. [Lin, Chin-Teng; Li, Shih-Yu; Lu, Shao-Wei] Natl Chiao Tung Univ, Brain Res Ctr, Hsinchu 30010, Taiwan. [Jung, Tzyy-Ping] Univ Calif San Diego, Inst Neural Computat, Swartz Ctr Computat Neurosci, La Jolla, CA 92093 USA. [Gordon, Stephen] DCS Corp, Alexandria, VA 22310 USA. RP McDowell, K (reprint author), US Army Res Lab, Translat Neurosci Branch, Aberdeen Proving Ground, MD 21005 USA. EM kgm8@cornell.edu OI Hairston, W. David/0000-0003-4432-8430 FU U.S. Army Research Laboratory [W911NF-10-2-0022] FX This work was supported by the U.S. Army Research Laboratory and, in part, under Cooperative Agreement W911NF-10-2-0022. NR 106 TC 28 Z9 28 U1 5 U2 8 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 2169-3536 J9 IEEE ACCESS JI IEEE Access PY 2013 VL 1 BP 131 EP 149 DI 10.1109/ACCESS.2013.2260791 PG 19 WC Computer Science, Information Systems; Engineering, Electrical & Electronic; Telecommunications SC Computer Science; Engineering; Telecommunications GA V42ZW UT WOS:000209652700011 ER PT J AU Fink, J Ribeiro, A Kumar, V AF Fink, Jonathan Ribeiro, Alejandro Kumar, Vijay TI Robust Control of Mobility and Communications in Autonomous Robot Teams SO IEEE ACCESS LA English DT Article DE Routing protocols; path planning; wireless networks; autonomous agents AB A team of robots are deployed to accomplish a task while maintaining a viable ad-hoc network capable of supporting data transmissions necessary for task fulfillment. Solving this problem necessitates: 1) estimation of the wireless propagation environment to identify viable point-to-point communication links; 2) determination of end-to-end routes to support data traffic; and 3) motion control algorithms to navigate through spatial configurations that guarantee required minimum levels of service. Therefore, we present methods for: 1) estimation of point-to-point channels using pathloss and spatial Gaussian process models; 2) data routing so as to determine suitable end-to-end communication routes given estimates of point-to-point channel rates; and 3) motion planning to determine robot trajectories restricted to configurations that ensure survival of the communication network. Because of the inherent uncertainty of wireless channels, the model of links and routes is stochastic. The criteria for route selection is to maximize the probability of network survival defined as the ability to support target communication rates given achievable rates on local point-to-point links. Maximum survival probability routes for present and future positions are input into a mobility control module that determines robot trajectories restricted to configurations that ensure the probability of network survival stays above a minimum reliability level. Local trajectory planning is proposed for simple environments and global planning is proposed for complex surroundings. The three proposed components are integrated and tested in experiments run in two different environments. Experimental results show successful navigation with continuous end-to-end connectivity. C1 [Fink, Jonathan] US Army Res Lab, Adelphi, MD 20783 USA. [Ribeiro, Alejandro] Univ Penn, Dept Elect & Syst Engn, Philadelphia, PA 19104 USA. [Kumar, Vijay] Univ Penn, Grasp Lab, Philadelphia, PA 19104 USA. RP Fink, J (reprint author), US Army Res Lab, Adelphi, MD 20783 USA. EM jonathan.r.fink3.civ@mail.mil FU ARL MAST-CTA [W911NF-08-2-0004]; AFOSR MURI [FA9550-10-1-0567] FX This work was supported by the ARL MAST-CTA under Grant W911NF-08-2-0004 and the AFOSR MURI under Grant FA9550-10-1-0567. NR 41 TC 17 Z9 17 U1 1 U2 3 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 2169-3536 J9 IEEE ACCESS JI IEEE Access PY 2013 VL 1 BP 290 EP 309 DI 10.1109/ACCESS.2013.2262013 PG 20 WC Computer Science, Information Systems; Engineering, Electrical & Electronic; Telecommunications SC Computer Science; Engineering; Telecommunications GA V42ZW UT WOS:000209652700023 ER PT B AU Boettner, DD Benson, MJ Bluman, JE Van Poppel, BP Arnas, AO AF Boettner, Daisie D. Benson, Michael J. Bluman, James E. Van Poppel, Bret P. Arnas, A. Ozer GP ASME TI EXPLAINING EXERGY - A CYCLE APPROACH SO INTERNATIONAL MECHANICAL ENGINEERING CONGRESS AND EXPOSITION - 2012, VOL 6, PTS A AND B LA English DT Proceedings Paper CT ASME International Mechanical Engineering Congress and Exposition CY NOV 09-15, 2012 CL Houston, TX SP ASME AB The exergy of a system at a given state traditionally is defined as the maximum potential useful work available from the system as it reaches equilibrium with its surroundings or a specified state (dead state). Boettner, et al. [1] demonstrate consideration of work required to restore the system to its original state is inherent in the definition of exergy. They provide a visual interpretation for the concept of exergy of a closed system whose temperature and pressure are above those of the dead state: closed system exergy corresponds to the sum of net work associated with a power cycle and a heat pump cycle with both cycles incorporating the system state and the dead state. On further investigation, the second cycle is not limited to a heat pump cycle and can be modeled as either a power cycle or a refrigeration/heat pump cycle. This paper simplifies the analysis such that one can immediately graph on a pressure-volume diagram and a temperature-entropy diagram a cycle whose enclosed area represents the exergy of a closed system at state i interacting with its surroundings (dead state). This paper also examines the case in which the closed system temperature and pressure are below those of the dead state. [1] Boettner, D.D., Bluman, J., Rowland, M., Bodenhamer, J., and Amas, A.O., 2011, "Graphical Interpretation of Exergy," Proceedings of the ASME 2011 International Mechanical Engineering Congress and Exposition, Denver, CO, Nov 11-17, IMECE2011-63099. C1 [Boettner, Daisie D.; Benson, Michael J.; Van Poppel, Bret P.; Arnas, A. Ozer] US Mil Acad, West Point, NY 10996 USA. [Bluman, James E.] Armed Scout Prod Off, Redstone Arsenal, AL USA. RP Boettner, DD (reprint author), US Mil Acad, West Point, NY 10996 USA. NR 12 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC MECHANICAL ENGINEERS PI NEW YORK PA THREE PARK AVENUE, NEW YORK, NY 10016-5990 USA BN 978-0-7918-4522-6 PY 2013 BP 1005 EP 1016 PG 12 WC Energy & Fuels; Engineering, Mechanical SC Energy & Fuels; Engineering GA BC1GD UT WOS:000350070400113 ER PT B AU Tzeng, JT Emerson, RP O'Brien, DJ AF Tzeng, Jerome T. Emerson, Ryan P. O'Brien, Daniel J. GP ASME TI Viscoelasticity Analysis and Experimental Validation of Anisotropic Composite Overwrap Cylinders SO INTERNATIONAL MECHANICAL ENGINEERING CONGRESS AND EXPOSITION - 2012, VOL 8 LA English DT Proceedings Paper CT ASME International Mechanical Engineering Congress and Exposition CY NOV 09-15, 2012 CL Houston, TX SP ASME ID SOLIDS; MEDIA AB Stress relaxation and creep of composite cylinders are investigated based on anisotropic viscoelasticity. The analysis accounts for ply-by-ply variation of material properties, ply orientations, and temperature gradients through the thickness of cylinders subjected to mechanical and thermal loads. Experimental validation of the model is conducted using a high-tensioned composite overwrapped on a steel cylinder. The creep and stress relaxation response of composite is accelerated at elevated temperatures, then characterized and compared to the model simulation. Fiber reinforced composite materials generally illustrate extreme anisotropy in viscoelastic behavior. Viscoelastic effects of the composite can result in a drastic change of stress and strain profiles in the cylinders over a period of time, which is critical for structural durability of composite cylinders. The developed analysis can be applied to composite pressure vessels, gun barrels, and flywheels design of life prediction. C1 [Tzeng, Jerome T.; Emerson, Ryan P.; O'Brien, Daniel J.] US Army Res Lab, Weap & Mat Res Directorate, Attn RDRL WMM A, Aberdeen Proving Ground, MD 21005 USA. RP Tzeng, JT (reprint author), US Army Res Lab, Weap & Mat Res Directorate, Attn RDRL WMM A, Aberdeen Proving Ground, MD 21005 USA. NR 12 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC MECHANICAL ENGINEERS PI NEW YORK PA THREE PARK AVENUE, NEW YORK, NY 10016-5990 USA BN 978-0-7918-4524-0 PY 2013 BP 429 EP 436 PG 8 WC Engineering, Mechanical; Materials Science, Multidisciplinary SC Engineering; Materials Science GA BC1GF UT WOS:000350070600057 ER PT B AU Kulkarni, SG Gao, XL David, NV Horner, SE Zheng, JQ AF Kulkarni, S. G. Gao, X. -L. David, N. V. Horner, S. E. Zheng, J. Q. GP ASME TI BALLISTIC HELMETS: THEIR DESIGN, MATERIALS, AND PERFORMANCE AGAINST TRAUMATIC BRAIN INJURY SO INTERNATIONAL MECHANICAL ENGINEERING CONGRESS AND EXPOSITION - 2012, VOL 8 LA English DT Proceedings Paper CT ASME International Mechanical Engineering Congress and Exposition CY NOV 09-15, 2012 CL Houston, TX SP ASME ID CENTRAL-NERVOUS-SYSTEM; CARBON NANOTUBES; BLAST-WAVE; TISSUE; MODEL; HEAD; DEFORMATION; BEHAVIOR; POLYMER; IMPACT AB Protecting a soldier's head from injury is critical to function and survivability. Traditionally, combat helmets have been utilized to provide protection against shrapnel and ballistic threats, which have reduced head injuries and fatalities. However, home-made bombs or improvised explosive devices (IEDs) have been increasingly used in theatre of operations since the Iraq and Afghanistan conflicts. Traumatic brain injury (TBI), particularly blast-induced TBI, which is typically not accompanied by external body injuries, is becoming increasingly prevalent among injured soldiers. The response of personal protective equipment, especially combat helmets, to blast events is relatively unknown. There is an urgent need to develop head protection systems with blast protection/ mitigation capabilities in addition to ballistic protection. Modern military operations, ammunitions, and technology driven war tactics require a lightweight headgear that integrates protection mechanisms (against ballistics, blasts, heat, and noise), sensors, night vision devices, and laser range finders into a single system. The current paper provides a comparative study on the design, materials, ballistic and blast performance of the combat helmets used by the U.S. Army based on a comprehensive and critical review of existing studies. Mechanisms of ballistic energy absorption, effects of helmet curvatures on ballistic performance, and performance measures of helmets are discussed. Properties of current helmet materials (including Kevlar K29 and K129 fibers, and thermoset resins) and future candidate materials for helmets (such as nano-composites, thermoplastic polymers, and carbon fibers) are elaborated. Also, experimental and computational studies on blast-induced fBI are examined, and constitutive models developed for brain tissues are reviewed. Finally, the effectiveness of current combat helmets against TBI is analyzed along with possible avenues for future research. C1 [Kulkarni, S. G.] Texas A&M Univ, Dept Mech Engn, College Stn, TX 77843 USA. [Gao, X. -L.] Univ Texas Dallas, Dept Mech Engn, Richardson, TX 75080 USA. [David, N. V.] Univ Teknol MARA, Fac Mech Engn, Shah Alam 40450, Selangor, Malaysia. [Horner, S. E.; Zheng, J. Q.] US Army, Program Execut Off Soldier, Ft Belvoir, VA USA. RP Gao, XL (reprint author), Univ Texas Dallas, Dept Mech Engn, Richardson, TX 75080 USA. EM Xin-Lin.Gao@utdallas.edu NR 115 TC 0 Z9 0 U1 1 U2 4 PU AMER SOC MECHANICAL ENGINEERS PI NEW YORK PA THREE PARK AVENUE, NEW YORK, NY 10016-5990 USA BN 978-0-7918-4524-0 PY 2013 BP 567 EP 587 PG 21 WC Engineering, Mechanical; Materials Science, Multidisciplinary SC Engineering; Materials Science GA BC1GF UT WOS:000350070600073 ER PT B AU Chao, NH Dispenza, JA DeAngelis, ME AF Chao, Nien-Hua Dispenza, John A. DeAngelis, Mario E. GP ASME TI Encapsulating Protective Layers for Enhancing Survivability of Circuit Board Assemblies in Harsh and Extreme Environments SO INTERNATIONAL MECHANICAL ENGINEERING CONGRESS AND EXPOSITION - 2012, VOL 9, PTS A AND B LA English DT Proceedings Paper CT ASME International Mechanical Engineering Congress and Exposition CY NOV 09-15, 2012 CL Houston, TX SP ASME AB Potted electronics are becoming more common in precision-guided artillery-launched munitions and also missile systems due to the requirements for miniaturization and structural-robustness. In this paper we have presented a methodology for encapsulating circuit board assemblies (CBA) with a thin polymer layer. The protective polymer layer is both flexible and soft enough to protect the CBA from damage caused by CTE mismatches, and without any appreciable degradation in the structural support during the high-g forces of projectile launch. The application process described here allows for the use of a broad range of polymer materials including those that may not be formed directly against an actual CBA. Proof-of-concept experimental tests and finite-element simulations have been performed and the tests and simulation results are shared in this paper. In addition, the protective polymer layer can also be used to improve in-circuit board crosstalk and RF interference shielding, tin-whisker growth control, moisture barrier properties, and thermal management for un-potted and potted CBAs. C1 [Chao, Nien-Hua; DeAngelis, Mario E.] US Army, ARDEC, Picatinny Arsenal, NJ USA. [Dispenza, John A.] Design Results LLC, Long Valley, NJ USA. RP Chao, NH (reprint author), US Army, ARDEC, Picatinny Arsenal, NJ USA. NR 17 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC MECHANICAL ENGINEERS PI NEW YORK PA THREE PARK AVENUE, NEW YORK, NY 10016-5990 USA BN 978-0-7918-4525-7 PY 2013 BP 363 EP 373 PG 11 WC Engineering, Mechanical; Nanoscience & Nanotechnology SC Engineering; Science & Technology - Other Topics GA BC1ZR UT WOS:000350613200053 ER PT J AU Monism, LM Netherland, MD AF Monism, Leeann M. Netherland, Michael D. TI Use of a small-scale primary screening method to predict effects of flumioxazin and carfentrazone-ethyl on native and invasive, submersed plants SO JOURNAL OF AQUATIC PLANT MANAGEMENT LA English DT Article DE electrolyte leakage; herbicide screening; protoporphyrinogen oxidase inhibitor AB When evaluating potential use patterns of new aquatic herbicides, it is important to determine effects on target as well as nontarget vegetation. Small-scale primary screens that provide data on the relative sensitivity of a species to a given herbicide or herbicide use rate can be used to enhance the design of more-costly and time-consuming, large-scale, growth-chamber and mesocosm studies. Flumioxazin (2-[7-fluoro-3,4-dihydro-3-oxo-4-(2-propynyl)-2H-1,4-benzoxazin-6-yl]-4,5,6,7-tetrahydro-1H-isoindole- 1,3(2H)-dione) and carfentrazone-ethyl (ethyl alpha,2-dichloro-5-[4-(difluoromethyl)-4,5-dihydro-3-methyl-5-oxo-1H-1,2,4- triaol-1-yl]-4-fluorobenzenepropanoate) are protoporphyrinogen oxidase (protox)-inhibiting herbicides recently registered by the U.S. Environmental Protection Agency (USEPA) for use in aquatic sites. These protox inhibitors disrupt chlorophyll synthesis and result in formation of oxygen radicals that damage cell membranes, causing them to leak cell contents. This leakage of electrolytes was measured and used to determine herbicide injury following exposure to protox inhibitors. Electrolyte leakage was measured at 5 d posttreatment for 15 submersed aquatic plant species exposed to flumioxazin at 0, 200, and 400 mu g ai (0, 0.0000265, and 0.000053 ppb) and to carfentrazoneethyl at 0 and 200 mu g ai L-1 in small-scale laboratory assays. In these assays, flumioxazin significantly increased electrolyte leakage for coontail (Ceratophyllum demersum L.) and curlyleaf pondweed (Potamogeton crisps L.). Eurasian water-milfoil (Myriophyllum spicatum L.). fanwort (Cabomba caroliniana Gray), hydrilla verticillata (L. 11) Royle], longbeak buttercup (Ranunculus longirostris Godr.). springtape (Sagittaria kurziana Gluck), variable watermilfoil (Myriophyllum heterophyllum Michx.), and waterstargrass [Heteranthera (labia (Jacq.) MacM.]. Species that were not significantly affected by flumioxazin included American pondweed (Potamogeton nodosus Poir.), common elodea (Elodea canadensis Michx.), Illinois pondweed (Potamogeton illinoensis Morong), sago pondweed Stuckenia pectinatus (L.) Boerner], southern naiad [Najas guadalupensis (Spreng.) Magnus], and American eel-grass (Vallisneria americana Michx.). Of the species tested, carfentrazone-ethyl only increased electrolyte leakage of coontail. Eurasian watermilfoil, and variable watermilfoil. C1 [Monism, Leeann M.] US Army Engn Res & Dev Ctr, Lewisville Aquat Ecosyst Res Facil, Lewisville, TX 75057 USA. [Netherland, Michael D.] US Army Engn Res & Dev Ctr, Ctr Aquat & Invas Plants, Gainesville, FL 75057 USA. RP Monism, LM (reprint author), US Army Engn Res & Dev Ctr, Lewisville Aquat Ecosyst Res Facil, 201 E Jones St, Lewisville, TX 75057 USA. EM LecAnn.M.Glomskiai@usace.army.mil FU Aquatic Plant Control Research Program (APCRP) FX Support for this project was provided by the Aquatic Plant Control Research Program (APCRP). The authors would like to thank Scott Western for technical assistance. Permission to publish on this information was granted by the Chief of Engineers. Citation of trade names does not constitute an official endorsement or approval of the use of such products. NR 28 TC 2 Z9 2 U1 1 U2 6 PU AQUATIC PLANT MANAGEMENT SOC, INC PI VICKSBURG PA PO BOX 821265, VICKSBURG, MS 39182 USA SN 0146-6623 J9 J AQUAT PLANT MANAGE JI J. Aquat. Plant Manage. PD JAN PY 2013 VL 51 BP 45 EP 48 PG 4 WC Plant Sciences; Marine & Freshwater Biology SC Plant Sciences; Marine & Freshwater Biology GA V39YF UT WOS:000209445600008 ER PT J AU Poovey, AG Mudge, CR Getsinger, KD Sedivy, H AF Poovey, Angela G. Mudge, C. R. Getsinger, K. D. Sedivy, H. TI Control of submersed flowering rush with contact and systemic aquatic herbicides under experimental conditions SO JOURNAL OF AQUATIC PLANT MANAGEMENT LA English DT Article C1 [Poovey, Angela G.; Mudge, C. R.; Getsinger, K. D.] US Army Engn Res & Dev Ctr, Vicksburg, MS 39180 USA. [Sedivy, H.] Sanders Cty, Thompson Falls, MT 59873 USA. RP Poovey, AG (reprint author), US Army Engn Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM Angela.G.Poovey@usace.army.mil FU Pelican River Watershed District; U.S. Army Engineer Seattle District; Aquatic Ecosystem Restoration Foundation FX Support and cooperation for this work were provided by the Pelican River Watershed District, the U.S. Army Engineer Seattle District, and the Aquatic Ecosystem Restoration Foundation. Mike Netherland, John Skogerboe, and Lee Ann Glomski kindly provided technical assistance and reviewed earlier versions of this manuscript. Special thanks are extended to Michelle Marko (Concordia College) and Betsy Hull (Albeni Falls Project, U.S. Army Engineer Seattle District) for rhizome collections. Additional support was provided by Craig Brengle (Albeni Falls Project, U.S. Army Engineer Seattle District) and Tera Guetter (Pelican River Watershed District). Permission was granted by the Chief of Engineers to publish this information. Citation of trade names does not constitute art official endorsement or approval of the use of such commercial products. NR 34 TC 4 Z9 4 U1 0 U2 1 PU AQUATIC PLANT MANAGEMENT SOC, INC PI VICKSBURG PA PO BOX 821265, VICKSBURG, MS 39182 USA SN 0146-6623 J9 J AQUAT PLANT MANAGE JI J. Aquat. Plant Manage. PD JAN PY 2013 VL 51 BP 53 EP 61 PG 9 WC Plant Sciences; Marine & Freshwater Biology SC Plant Sciences; Marine & Freshwater Biology GA V39YF UT WOS:000209445600010 ER PT J AU Glomski, LM Mudge, CR AF Glomski, Leeann M. Mudge, Christopher R. TI Effect of subsurface and foliar applications of bispyribac-sodium on water hyacinth, water lettuce, and giant salvinia SO JOURNAL OF AQUATIC PLANT MANAGEMENT LA English DT Article C1 [Glomski, Leeann M.] US Army Engn Res & Dev Ctr, Lewisville Aquat Ecosyst Res Facil, Lewisville, TX 75057 USA. [Mudge, Christopher R.] US Army Engn Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Glomski, LM (reprint author), US Army Engn Res & Dev Ctr, Lewisville Aquat Ecosyst Res Facil, 201 E Jones St, Lewisville, TX 75057 USA. EM LecAnn.M.Gloniski@ustice.army FU U.S. Army Engineer Research and Development Center; Aquatic Plant Control Research Program; Aquatic Ecosystem Restoration Foundation; Valent USA Corporation FX Support for this research was provided by the U.S. Army Engineer Research and Development Center, Aquatic Plant Control Research Program, the Aquatic Ecosystem Restoration Foundation, and Valent USA Corporation. Use of trade name does not indicate endorsement of such products. Permission was granted by the Chief of Engineers to publish this information. NR 22 TC 2 Z9 2 U1 0 U2 0 PU AQUATIC PLANT MANAGEMENT SOC, INC PI VICKSBURG PA PO BOX 821265, VICKSBURG, MS 39182 USA SN 0146-6623 J9 J AQUAT PLANT MANAGE JI J. Aquat. Plant Manage. PD JAN PY 2013 VL 51 BP 62 EP 65 PG 4 WC Plant Sciences; Marine & Freshwater Biology SC Plant Sciences; Marine & Freshwater Biology GA V39YF UT WOS:000209445600011 ER PT J AU Milner, JL Bunget, C Abu-Farha, F Kurfess, T Hammond, VH AF Milner, Justin L. Bunget, Cristina Abu-Farha, Fadi Kurfess, Thomas Hammond, Vincent H. TI Modeling tensile strength of materials processed by accumulative roll bonding SO JOURNAL OF MANUFACTURING PROCESSES LA English DT Article DE Accumulative roll bonding; Severe plastic deformation; Strengthening modeling AB Nanostructured materials are a relatively new class of materials that exhibit advanced mechanical properties, thus improving performance and capabilities of products, with potential applications in the automotive, aerospace and defense industries. Among the severe plastic deformation (SPD) methods currently used for achieving nanoscale structures, accumulative roll bonding (ARB) is the most favorable method to produce grain refinement for continuous production of metallic sheets at a bulk scale. In this article, a model that describes the evolution of material strength due to processing via accumulative roll bonding was developed. ARB experiments were conducted on CP-Ti Grade 2 at a selected set of conditions. The results showed significant grain refinement in the microstructure (down to similar to 120 nm) and a two-fold increase in tensile strength as compared to the as-received material. The developed model was validated using the experimental data, and exhibited a good fit over the entire range of ARB processing cycles. To further validate the model and ensure its robustness for a wider array of materials (beyond CP-Ti), a review of efforts on ARB processing was carried out for five other materials with different initial microstructures, mechanical properties, and even crystalline structures. The model was still able to capture the strengthening trends in all considered materials. (C) 2013 The Society of Manufacturing Engineers. Published by Elsevier Ltd. All rights reserved. C1 [Milner, Justin L.; Bunget, Cristina; Abu-Farha, Fadi] Clemson Univ, Dept Automot Engn, Greenville, SC 29607 USA. [Kurfess, Thomas] Georgia Inst Technol, Dept Mech Engn, Atlanta, GA 30332 USA. [Hammond, Vincent H.] US Army Res Lab, Aberdeen Proving Ground, Aberdeen Proving Ground, MD 21005 USA. RP Milner, JL (reprint author), Clemson Univ, Dept Automot Engn, Greenville, SC 29607 USA. EM jlmilne@clemson.edu FU US Army Research Laboratory [W911NF-10-1-0413] FX The authors are grateful to RTI International Metals for providing access to the rolling mill using which all the ARB runs reported in this work were performed. The authors are also grateful to JTEKT - Greenville Technology Center for helping with tensile testing. All the electron microscopy work was performed at the Advanced Material Research Lab (AMRL) of Clemson University; the efforts of their team are greatly appreciated. This work was supported in part by the US Army Research Laboratory under grant number W911NF-10-1-0413. NR 24 TC 4 Z9 4 U1 0 U2 5 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1526-6125 J9 J MANUF PROCESS JI J. Manuf. Process. PY 2013 VL 15 IS 2 BP 219 EP 226 DI 10.1016/j.jmapro.2013.02.001 PG 8 WC Engineering, Manufacturing SC Engineering GA V37JN UT WOS:000209272200005 ER PT B AU Bhattacharjee, AK AF Bhattacharjee, Apurba K. BE Devillers, J TI In Silico Stereoelectronic Profile and Pharmacophore Similarity Analysis of Juvenile Hormone, Juvenile Hormone Mimics (IGRs), and Insect Repellents May Aid Discovery and Design of Novel Arthropod Repellents SO JUVENILE HORMONES AND JUVENOIDS: MODELING BIOLOGICAL EFFECTS AND ENVIRONMENTAL FATE SE QSAR in Environmental and Health Sciences LA English DT Article; Book Chapter DE In silico stereo-electronic properties; Quantum chemical calculations; 3D pharmacophore; DEET; Juvenile hormone mimics (IGRs); Juvenile hormone (JH) ID N,N-DIETHYL-M-TOLUAMIDE DEET ANALOGS; MOLECULAR ELECTRONIC-PROPERTIES; AEDES-AEGYPTI; MOSQUITO VECTORS; ELECTROSTATIC POTENTIALS; TOBACCO HORNWORM; DRUG DISCOVERY; CORPORA-ALLATA; MODEL; FIELD AB The chapter presents a comparative analysis of quantum chemically calculated stereo-electronic properties of DEET, DEET-like compounds, juvenile hormone mimics (IGRs), and juvenile hormone (JH). The results led to unravel several interesting molecular level information, most significant of which was electrostatic bio-isosterism between the compounds. Observation of similarity of stereo-electronic properties of the amide/ester moiety, negative electrostatic potential regions beyond the van der Waals surface, and large distribution of weak electrostatic potential (hydrophobic) regions in the compounds provided a model for molecular recognition with the receptor at a distance. In addition, the chapter discusses how these stereo-electronic attributes could be organized to develop a feature based on three-dimensional pharmacophore model for arthropod repellent activity and demonstrates how the model could be utilized for search of compound databases to identify new repellent compounds and aid in the design of novel repellents for custom synthesis. Since identity of the target for arthropod repellent activity still remains uncertain, the in silico approaches presented in the chapter should be useful for discovery and design of potentially well-tolerated, target-specific arthropod repellents for practical use. C1 Walter Reed Army Inst Res, Div Expt Therapeut, Dept Med Chem, Silver Spring, MD 20910 USA. RP Bhattacharjee, AK (reprint author), Walter Reed Army Inst Res, Div Expt Therapeut, Dept Med Chem, Silver Spring, MD 20910 USA. NR 69 TC 0 Z9 1 U1 0 U2 0 PU CRC PRESS-TAYLOR & FRANCIS GROUP PI BOCA RATON PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA BN 978-1-4665-1322-8; 978-1-4665-1321-1 J9 QSAR ENVIRON HEALTH PY 2013 BP 311 EP 346 D2 10.1201/b14899 PG 36 WC Biology; Endocrinology & Metabolism; Toxicology SC Life Sciences & Biomedicine - Other Topics; Endocrinology & Metabolism; Toxicology GA BD4WK UT WOS:000361147000014 ER PT B AU Sorenson, G AF Sorenson, Georgia BE Monopoli, P McCarty, S TI The Nexus between Leadership Theory and Law SO LAW AND LEADERSHIP: INTEGRATING LEADERSHIP STUDIES INTO THE LAW SCHOOL CURRICULUM SE Emerging Legal Education LA English DT Article; Book Chapter C1 [Sorenson, Georgia] US Army, Transformat Leadership, Washington, DC 20310 USA. RP Sorenson, G (reprint author), Sch Law, Leadership Studies, Rochester, MN 55904 USA. NR 27 TC 0 Z9 0 U1 0 U2 0 PU ASHGATE PUBLISHING LTD PI ALDERSHOT PA GOWER HOUSE, CROFT ROAD, ALDERSHOT GU11 3HR, ENGLAND BN 978-1-4094-5022-1; 978-1-4094-5021-4 J9 EMERG LEGAL EDUC PY 2013 BP 19 EP 34 PG 16 WC Education & Educational Research; Law SC Education & Educational Research; Government & Law GA BF9MR UT WOS:000385761100005 ER PT B AU Brown, JS Allen, B Sorenson, G Pearson, C Couto, R Harris, N AF Brown, Judy Sorum Allen, Bonnie Sorenson, Georgia Pearson, Carol Couto, Richard Harris, Nina BE Monopoli, P McCarty, S TI Leadership Education in the Legal Academy: Principles, Practices and Possibilities A Report from the James MacGregor Burns Academy of LeadershipUniversity of Maryland SO LAW AND LEADERSHIP: INTEGRATING LEADERSHIP STUDIES INTO THE LAW SCHOOL CURRICULUM SE Emerging Legal Education LA English DT Article; Book Chapter C1 [Brown, Judy Sorum] Univ Maryland, Ctr Publ Policy & Private Enterprise, College Pk, MD 20742 USA. [Allen, Bonnie] Mississippi Ctr Justice, Access Justice Partnerships, Jackson, MS USA. [Allen, Bonnie] Fetzer Inst, Ctr Law & Renewal, Several Natl & Local Nonprofit Org, Kalamazoo, MI USA. [Allen, Bonnie] Sch Law, Rochester, MN USA. [Sorenson, Georgia] US Army, Transformat Leadership, Panama City, FL USA. [Sorenson, Georgia] Employment White House, Washington, DC USA. [Sorenson, Georgia] Commiss Civil Rights, Washington, DC USA. [Sorenson, Georgia] Natl Inst Educ, Singapore, Singapore. RP Brown, JS (reprint author), Univ Maryland, Ctr Publ Policy & Private Enterprise, College Pk, MD 20742 USA. NR 26 TC 0 Z9 0 U1 0 U2 0 PU ASHGATE PUBLISHING LTD PI ALDERSHOT PA GOWER HOUSE, CROFT ROAD, ALDERSHOT GU11 3HR, ENGLAND BN 978-1-4094-5022-1; 978-1-4094-5021-4 J9 EMERG LEGAL EDUC PY 2013 BP 263 EP 282 PG 20 WC Education & Educational Research; Law SC Education & Educational Research; Government & Law GA BF9MR UT WOS:000385761100020 ER PT J AU Jian, WW Cheng, GM Xu, WZ Yuan, H Tsai, MH Wang, QD Koch, CC Zhu, YT Mathaudhu, SN AF Jian, W. W. Cheng, G. M. Xu, W. Z. Yuan, H. Tsai, M. H. Wang, Q. D. Koch, C. C. Zhu, Y. T. Mathaudhu, S. N. TI Ultrastrong Mg Alloy via Nano-spaced Stacking Faults SO MATERIALS RESEARCH LETTERS LA English DT Article DE Stacking Faults; Mg; Strength; Ductility; Dislocations AB Mg alloys are among the lightest alloys but they are usually weak. Here we report a new mechanism to make them ultrastrong while maintaining good ductility. Stacking faults with nanoscale spacing were introduced into a Mg-8.5Gd-2.3Y-1.8Ag-0.4Zr (wt%) alloy by conventional hot rolling, which produced a yield strength of similar to 575 MPa, an ultimate strength of similar to 600 MPa, and a uniform elongation of similar to 5.2 %. Low stacking fault (SF) energy enabled the introduction of a high density of SFs, which impeded dislocation slip and promoted dislocation accumulation. These findings provide guidance for developing Mg alloys with superior mechanical properties. C1 [Jian, W. W.; Cheng, G. M.; Xu, W. Z.; Yuan, H.; Tsai, M. H.; Koch, C. C.; Zhu, Y. T.; Mathaudhu, S. N.] North Carolina State Univ, Dept Mat Sci & Engn, Box 7907, Raleigh, NC 27695 USA. [Wang, Q. D.] Shanghai Jiao Tong Univ, Sch Mat Sci & Engn, Shanghai, Peoples R China. [Mathaudhu, S. N.] US Army, Mat Sci Div, Res Off, Res Triangle Pk, NC 27709 USA. RP Zhu, YT (reprint author), North Carolina State Univ, Dept Mat Sci & Engn, Box 7907, Raleigh, NC 27695 USA. EM ytzhu@ncsu.edu; suveen.n.mathaudhu.civ@mail.mil RI Zhu, Yuntian/B-3021-2008; Cheng, Guangming/F-8999-2010; Tsai, Ming-Hung/C-2294-2008; Yuan, Hao/J-6139-2012 OI Zhu, Yuntian/0000-0002-5961-7422; Cheng, Guangming/0000-0001-5852-1341; Yuan, Hao/0000-0002-4879-3420 FU U.S. Army Research Office [W911NF-12-1-0009]; National Natural Science Foundation of China [51074106] FX This work was supported by the U.S. Army Research Office under grant no. W911NF-12-1-0009. QDW is supported by the National Natural Science Foundation of China under grant no. 51074106 NR 59 TC 71 Z9 73 U1 11 U2 11 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA SN 2166-3831 J9 MATER RES LETT JI Mater. Res. Lett. PY 2013 VL 1 IS 2 BP 61 EP 66 DI 10.1080/21663831.2013.765927 PG 6 WC Materials Science, Multidisciplinary SC Materials Science GA V44RZ UT WOS:000209767400001 ER PT B AU Grenn, MW Vizgaitis, J Pellegrino, JG Perconti, P AF Grenn, Michael W. Vizgaitis, Jay Pellegrino, Joseph G. Perconti, Philip BE Diakides, M Bronzino, JD Peterson, DR TI Infrared Camera and Optics for Medical Applications SO MEDICAL INFRARED IMAGING: PRINCIPLES AND PRACTICES LA English DT Article; Book Chapter C1 [Grenn, Michael W.; Vizgaitis, Jay; Pellegrino, Joseph G.; Perconti, Philip] US Army, CERDEC Night Vis & Elect Sensors Directorate, Ft Belvoir, VA 22060 USA. RP Grenn, MW (reprint author), US Army, CERDEC Night Vis & Elect Sensors Directorate, Ft Belvoir, VA 22060 USA. NR 9 TC 0 Z9 0 U1 0 U2 0 PU CRC PRESS-TAYLOR & FRANCIS GROUP PI BOCA RATON PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA BN 978-1-4398-7250-5; 978-1-4398-7249-9 PY 2013 PG 15 WC Engineering, Biomedical; Radiology, Nuclear Medicine & Medical Imaging SC Engineering; Radiology, Nuclear Medicine & Medical Imaging GA BC6MS UT WOS:000354125200006 ER PT B AU Norton, PR Horn, SB Pellegrino, JG Perconti, P AF Norton, Paul R. Horn, Stuart B. Pellegrino, Joseph G. Perconti, Philip BE Diakides, M Bronzino, JD Peterson, DR TI Infrared Detectors and Detector Arrays SO MEDICAL INFRARED IMAGING: PRINCIPLES AND PRACTICES LA English DT Article; Book Chapter ID INTEGRATED SENSOR ARRAYS; SUPERLATTICE; IMAGERS; CAMERA C1 [Norton, Paul R.; Horn, Stuart B.; Pellegrino, Joseph G.; Perconti, Philip] US Army, CERDEC Night Vis & Elect Sensors Directorate, Ft Belvoir, VA 22060 USA. RP Norton, PR (reprint author), US Army, CERDEC Night Vis & Elect Sensors Directorate, Ft Belvoir, VA 22060 USA. NR 41 TC 0 Z9 0 U1 0 U2 0 PU CRC PRESS-TAYLOR & FRANCIS GROUP PI BOCA RATON PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA BN 978-1-4398-7250-5; 978-1-4398-7249-9 PY 2013 PG 27 WC Engineering, Biomedical; Radiology, Nuclear Medicine & Medical Imaging SC Engineering; Radiology, Nuclear Medicine & Medical Imaging GA BC6MS UT WOS:000354125200004 ER PT B AU Pellegrino, JG Zeibel, J Driggers, RG Perconti, P AF Pellegrino, Joseph G. Zeibel, Jason Driggers, Ronald G. Perconti, Philip BE Diakides, M Bronzino, JD Peterson, DR TI Infrared Camera Characterization SO MEDICAL INFRARED IMAGING: PRINCIPLES AND PRACTICES LA English DT Article; Book Chapter C1 [Pellegrino, Joseph G.; Zeibel, Jason; Driggers, Ronald G.; Perconti, Philip] US Army, CERDEC Night Vis & Elect Sensors Directorate, Ft Belvoir, VA 22060 USA. RP Pellegrino, JG (reprint author), US Army, CERDEC Night Vis & Elect Sensors Directorate, Ft Belvoir, VA 22060 USA. NR 2 TC 0 Z9 0 U1 0 U2 0 PU CRC PRESS-TAYLOR & FRANCIS GROUP PI BOCA RATON PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA BN 978-1-4398-7250-5; 978-1-4398-7249-9 PY 2013 PG 10 WC Engineering, Biomedical; Radiology, Nuclear Medicine & Medical Imaging SC Engineering; Radiology, Nuclear Medicine & Medical Imaging GA BC6MS UT WOS:000354125200005 ER PT B AU Collen, J O'Malley, P Roy, M Sessums, L AF Collen, Jacob O'Malley, Patrick Roy, Michael Sessums, Laura BE Gross, ML Carrick, D TI Military Medical Ethics: Experience from Operation Iraqi Freedom SO MILITARY MEDICAL ETHICS FOR THE 21ST CENTURY SE Military and Defence Ethics LA English DT Article; Book Chapter C1 [Collen, Jacob] US Army, Washington, DC USA. [Collen, Jacob] 1st Infantry Div, Samarra, Iraq. [O'Malley, Patrick; Sessums, Laura] Uniformed Serv Univ Hlth Sci, Med, Bethesda, MD 20814 USA. [O'Malley, Patrick] Uniformed Serv Univ Hlth Sci, Gen Internal Med, Bethesda, MD 20814 USA. [O'Malley, Patrick] US Army, Med Corps, Washington, DC USA. [Roy, Michael] Uniformed Serv Univ Hlth Sci, Med, Bethesda, MD USA. [Roy, Michael] Uniformed Serv Univ Hlth Sci, Div Mil Internal Med, Bethesda, MD USA. [Roy, Michael] Soc Brain Mapping & Therapeut, Toronto, ON, Canada. [Roy, Michael] Amer Coll Physicians, Washington, DC USA. RP Collen, J (reprint author), Walter Reed Natl Mil Med Ctr, Pulm Crit Care & Sleep Med, Bethesda, MD 20889 USA. NR 4 TC 0 Z9 0 U1 0 U2 0 PU ASHGATE PUBLISHING LTD PI ALDERSHOT PA GOWER HOUSE, CROFT ROAD, ALDERSHOT GU11 3HR, ENGLAND BN 978-1-4094-3899-1; 978-1-4094-3898-4 J9 MILIT DEFEN ETHIC PY 2013 BP 17 EP 41 PG 25 WC History SC History GA BC4ER UT WOS:000352395900002 ER PT B AU Erickson, EN AF Erickson, Eric N., Jr. BE Gross, ML Carrick, D TI Institutional Review Board Specialization for Non-Lethal Weapon Research SO MILITARY MEDICAL ETHICS FOR THE 21ST CENTURY SE Military and Defence Ethics LA English DT Article; Book Chapter C1 [Erickson, Eric N., Jr.] US Army, Armament Res Dev & Engn Ctr, Picatinny Arsenal, NJ 07806 USA. [Erickson, Eric N., Jr.] New Jersey Air Natl Guard, Fighter Wing 177, Pomona, NJ USA. RP Erickson, EN (reprint author), US Army, Armament Res Dev & Engn Ctr, Picatinny Arsenal, NJ 07806 USA. NR 34 TC 0 Z9 0 U1 0 U2 0 PU ASHGATE PUBLISHING LTD PI ALDERSHOT PA GOWER HOUSE, CROFT ROAD, ALDERSHOT GU11 3HR, ENGLAND BN 978-1-4094-3899-1; 978-1-4094-3898-4 J9 MILIT DEFEN ETHIC PY 2013 BP 245 EP 259 PG 15 WC History SC History GA BC4ER UT WOS:000352395900016 ER PT J AU Schroden, J Thomasson, R Foster, R Lukens, M Bell, R AF Schroden, Jonathan Thomasson, Rebecca Foster, Randy Lukens, Mark Bell, Richard TI A New Paradigm for Assessment in Counter-insurgency SO MILITARY OPERATIONS RESEARCH LA English DT Article AB In September 2011, the Commander of the International Security Assistance Force (ISAF) in Afghanistan directed the Afghan Assessment Group to redesign the way in which ISAF was assessing progress in the war, and to be "revolutionary" in so doing. The resulting new assessment paradigm is novel, non-doctrinal, and effectively addresses the unique complexities of the counterinsurgency in Afghanistan and the needs of the ISAF Commander. It has a two-tier structure consisting of both strategic and campaign assessments. The former focuses on answering a set of strategic questions in narrative, analytic form to address the strategic environment while the latter uses a set of standards and accompanying narrative responses to gauge accomplishment of campaign tasks. Both tiers capture the current state of the war while maintaining an eye on future challenges and opportunities. The two assessments and their associated processes were designed to stimulate discussions leading directly to decisions by senior leaders on actions they could take, direct, or request. Such actions were the observed outcome of the first four iterations of the new paradigm. While any assessment paradigm will have advantages and disadvantages, an examination of the pros and cons of the new ISAF assessment paradigm makes clear that it should be considered a "best practice" in the field of counterinsurgency assessment. C1 [Schroden, Jonathan] Ctr Stabil & Dev, Washington, DC USA. [Foster, Randy] Univ Foreign Mil & Cultural Studies, Fort Leavenworth, FL USA. [Lukens, Mark; Bell, Richard] US Army, Washington, DC USA. RP Schroden, J (reprint author), Ctr Stabil & Dev, Washington, DC USA. EM Schrodj@cna.org NR 13 TC 0 Z9 0 U1 0 U2 0 PU MILITARY OPERATIONS RESEARCH SOC PI ALEXANDRIA PA 1703 N BEAUREGARD ST, STE 450, ALEXANDRIA, VA 22311-1717 USA SN 0275-5823 J9 MIL OPER RES JI Mil. Oper. Res. PY 2013 VL 18 IS 3 BP 5 EP 20 DI 10.5711/1082598318305 PG 16 WC Operations Research & Management Science SC Operations Research & Management Science GA V43NY UT WOS:000209689300001 ER PT J AU Yoho, KD Bummara, J Clark, W Kelley, C AF Yoho, Keenan D. Bummara, Justin Clark, William Kelley, Christopher TI Strategic Resource Allocation: Selecting Vessels to Support Maritime Irregular Warfare SO MILITARY OPERATIONS RESEARCH LA English DT Article AB The US Navy is at a critical juncture in determining the types and numbers of ships it will acquire, retire, and sustain to support an evolving US military strategy. In addition to determining how many aircraft carriers, cruisers, amphibious assault craft, fighters, and helicopters it will need, the Navy must determine how it will confront maritime irregular warfare. Assuming an environment of resource scarcity, where new vessel acquisition to support maritime irregular warfare may be increasingly difficult or unlikely, we introduce a method for evaluating the capability and costs of candidate vessels that are in the current Department of Defense inventory, or widely available from the commercial sector to conduct such a mission. Our method combines wargaming with cost analysis to aid Navy leadership in developing maritime irregular warfare concepts of operation as well as resource allocation decisions. C1 [Yoho, Keenan D.] Naval Postgrad Sch, Monterey, CA USA. [Bummara, Justin; Kelley, Christopher] US Navy, Washington, DC USA. [Clark, William] US Army, Washington, DC USA. RP Yoho, KD (reprint author), Naval Postgrad Sch, Monterey, CA USA. EM kdyoho@nps.edu; justin.bummara@fe.navy.mil; william.clark9@us.army.mil; christopher.kelley@navsoc.socom.mil NR 20 TC 0 Z9 0 U1 0 U2 0 PU MILITARY OPERATIONS RESEARCH SOC PI ALEXANDRIA PA 1703 N BEAUREGARD ST, STE 450, ALEXANDRIA, VA 22311-1717 USA SN 0275-5823 J9 MIL OPER RES JI Mil. Oper. Res. PY 2013 VL 18 IS 3 BP 21 EP 33 DI 10.5711/1082598318321 PG 13 WC Operations Research & Management Science SC Operations Research & Management Science GA V43NY UT WOS:000209689300002 ER PT J AU Chua, J Senft, JL Lockett, SJ DeShazer, D Friedlander, AM AF Chua, J. Senft, J. L. Lockett, S. J. DeShazer, D. Friedlander, A. M. TI Impact of host cell state on the efficiency of virus replication in a vaccine production process SO MOLECULAR BIOLOGY OF THE CELL LA English DT Meeting Abstract C1 [Chua, J.; Senft, J. L.; DeShazer, D.; Friedlander, A. M.] US Army Med Res Inst Infect Dis, Bacteriol, Ft Detrick, MD USA. [Lockett, S. J.] Frederick Natl Lab, Ft Detrick, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC CELL BIOLOGY PI BETHESDA PA 8120 WOODMONT AVE, STE 750, BETHESDA, MD 20814-2755 USA SN 1059-1524 EI 1939-4586 J9 MOL BIOL CELL JI Mol. Biol. Cell PY 2013 VL 24 MA 1520 PG 2 WC Cell Biology SC Cell Biology GA V38MY UT WOS:000209348703015 ER PT J AU Chua, J Senft, JL Lockett, SJ DeShazer, D Friedlander, AM AF Chua, J. Senft, J. L. Lockett, S. J. DeShazer, D. Friedlander, A. M. TI Chloroquine inhibits Burkholderia induced Multi-Nucleated Giant Cell Formation SO MOLECULAR BIOLOGY OF THE CELL LA English DT Meeting Abstract C1 [Chua, J.; Senft, J. L.; DeShazer, D.; Friedlander, A. M.] US Army Med Res Inst Infect Dis, Bacteriol, Ft Detrick, MD USA. [Lockett, S. J.] Frederick Natl Lab, Ft Detrick, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC CELL BIOLOGY PI BETHESDA PA 8120 WOODMONT AVE, STE 750, BETHESDA, MD 20814-2755 USA SN 1059-1524 EI 1939-4586 J9 MOL BIOL CELL JI Mol. Biol. Cell PY 2013 VL 24 MA 1519 PG 1 WC Cell Biology SC Cell Biology GA V38MY UT WOS:000209348703014 ER PT J AU Lindquist, M Schmaljohn, C AF Lindquist, M. Schmaljohn, C. TI Identification of the Sites of Hantavirus RNA Replication and Transcription Using In Situ Hybridization SO MOLECULAR BIOLOGY OF THE CELL LA English DT Meeting Abstract C1 [Lindquist, M.; Schmaljohn, C.] US Army, Res Inst Infect Dis, Frederick, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC CELL BIOLOGY PI BETHESDA PA 8120 WOODMONT AVE, STE 750, BETHESDA, MD 20814-2755 USA SN 1059-1524 EI 1939-4586 J9 MOL BIOL CELL JI Mol. Biol. Cell PY 2013 VL 24 MA 2261 PG 2 WC Cell Biology SC Cell Biology GA V38MY UT WOS:000209348704367 ER PT B AU Ruffin, PB Yin, S AF Ruffin, Paul B. Yin, Stuart (Shizhuo) BE Cusano, A Arregui, FJ Giordano, M Cutolo, A TI Nano-Optical Sensors for Explosive Detection SO OPTOCHEMICAL NANOSENSORS SE Series in Sensors LA English DT Article; Book Chapter ID RESONANCE; NANOPARTICLES; SPECTROSCOPY; COMPOSITES C1 [Ruffin, Paul B.] US Army Res Dev & Engn Command, Huntsville, AL 35898 USA. [Yin, Stuart (Shizhuo)] Penn State Univ, University Pk, PA 16802 USA. RP Ruffin, PB (reprint author), US Army Res Dev & Engn Command, Huntsville, AL 35898 USA. NR 26 TC 0 Z9 0 U1 0 U2 0 PU CRC PRESS-TAYLOR & FRANCIS GROUP PI BOCA RATON PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA BN 978-1-4398-5490-7; 978-1-4398-5489-1 J9 SER SENSORS PY 2013 BP 565 EP 585 PG 21 WC Chemistry, Applied; Engineering, Electrical & Electronic SC Chemistry; Engineering GA BD6DO UT WOS:000362097100024 ER PT S AU Thampan, T Shah, D Cook, C Novoa, J Shah, S AF Thampan, T. Shah, D. Cook, C. Novoa, J. Shah, S. BE Gasteiger, HA Weber, A Shinohara, K Uchida, H Mitsushima, S Schmidt, TJ Narayanan, SR Ramani, V Fuller, T Edmundson, M Strasser, P Mantz, R Fenton, J Buchi, FN Hansen, DC Jones, DL Coutanceau, C SwiderLyons, K Perry, KA TI Fuel Cells for Dismounted Warfighter Use SO POLYMER ELECTROLYTE FUEL CELLS 13 (PEFC 13) SE ECS Transactions LA English DT Proceedings Paper CT 13th Polymer Electrolyte Fuel Cell Symposium (PEFC) CY OCT 27-NOV 01, 2013 CL San Francisco, CA SP Electrochem Soc, Electrochem Soc, Ind Electrochemistry & Electrochem Engn Div, Electrochem Soc, Battery Div, Electrochem Soc, Corros Div, Electrochem Soc, Energy Technol Div, Electrochem Soc, Phys & Analyt Electrochemistry Div, N E Chemcat Corp AB Communications-Electronics Research, Development, and Engineering Center (CERDEC) has been developing fuel cell power sources for the US military, including warfighters use in an austere environment with minimum access to resupply and vehicular transportation. These dismounted warfighter applications require systems that are power and energy dense to minimize the load burden. A number of fuel cell products have been developed for these applications, and the performance of these systems are discussed. Significant advancements in power density and energy density have been made, resulting in increased relevance to users. Based on recent advances, it is anticipated that these fuel cells will be transitioned as a viable alternative to the incumbent power solutions upon successfully meeting cost, reliability and ergonomic targets. C1 [Thampan, T.; Shah, D.; Cook, C.; Novoa, J.; Shah, S.] US Army, RDECOM CERDEC CP&I, Army Power Div, Aberdeen Proving Ground, MD 21005 USA. RP Thampan, T (reprint author), US Army, RDECOM CERDEC CP&I, Army Power Div, 5100 Magazine Rd, Aberdeen Proving Ground, MD 21005 USA. NR 12 TC 1 Z9 1 U1 0 U2 0 PU ELECTROCHEMICAL SOC INC PI PENNINGTON PA 65 S MAIN ST, PENNINGTON, NJ 08534-2839 USA SN 1938-5862 BN 978-1-60768-446-6; 978-1-60768-445-9 J9 ECS TRANSACTIONS PY 2013 VL 58 IS 1 BP 183 EP 195 DI 10.1149/05801.0183ecst PG 13 WC Electrochemistry; Energy & Fuels SC Electrochemistry; Energy & Fuels GA BC6TH UT WOS:000354475600017 ER PT S AU Myles, TD Ren, X Grew, KN Chiu, WKS AF Myles, T. D. Ren, X. Grew, K. N. Chiu, W. K. S. BE Gasteiger, HA Weber, A Shinohara, K Uchida, H Mitsushima, S Schmidt, TJ Narayanan, SR Ramani, V Fuller, T Edmundson, M Strasser, P Mantz, R Fenton, J Buchi, FN Hansen, DC Jones, DL Coutanceau, C SwiderLyons, K Perry, KA TI Interaction and Transport of Carbon Dioxide in Alkaline Anion Exchange Membranes SO POLYMER ELECTROLYTE FUEL CELLS 13 (PEFC 13) SE ECS Transactions LA English DT Proceedings Paper CT 13th Polymer Electrolyte Fuel Cell Symposium (PEFC) CY OCT 27-NOV 01, 2013 CL San Francisco, CA SP Electrochem Soc, Electrochem Soc, Ind Electrochemistry & Electrochem Engn Div, Electrochem Soc, Battery Div, Electrochem Soc, Corros Div, Electrochem Soc, Energy Technol Div, Electrochem Soc, Phys & Analyt Electrochemistry Div, N E Chemcat Corp ID ALCOHOL FUEL-CELLS; NAFION MEMBRANE; CONDUCTIVITY; TEMPERATURE; PERMEABILITY; POLYMERS; METHANOL AB Transient measurements of CO2 cross-over through Tokuyama A201 membranes were made utilizing a permeation cell setup. The transient data was analyzed using a classical Fickian based model. Results were compared to Nafion 117 and it was found that the characteristic behavior of the transient data was different between the two membranes. Nafion 117 followed closely with the exponential behavior dictated by the Fickian based model while the A201 membrane displayed a behavior more closely resembling a sigmoid curve. The reason for this behavior is hypothesized to be related to either a breakdown of the modeling assumptions or the interaction of the alkaline membrane with CO2. C1 [Myles, T. D.; Chiu, W. K. S.] Univ Connecticut, Dept Mech Engn, Storrs, CT 06269 USA. [Ren, X.; Grew, K. N.] US Army Res Lab, Sensors & Elect Devices Directorate, Adelphi, MD 20783 USA. RP Ren, X (reprint author), US Army Res Lab, Sensors & Elect Devices Directorate, Adelphi, MD 20783 USA. EM xiaoming.ren.civ@mail.mil; wchiu@engr.uconn.edu NR 21 TC 0 Z9 0 U1 2 U2 2 PU ELECTROCHEMICAL SOC INC PI PENNINGTON PA 65 S MAIN ST, PENNINGTON, NJ 08534-2839 USA SN 1938-5862 BN 978-1-60768-446-6; 978-1-60768-445-9 J9 ECS TRANSACTIONS PY 2013 VL 58 IS 1 BP 431 EP 439 DI 10.1149/05801.0431ecst PG 9 WC Electrochemistry; Energy & Fuels SC Electrochemistry; Energy & Fuels GA BC6TH UT WOS:000354475600042 ER PT S AU Zakikhani, M Harrelson, DW Kissane, JA Allis, MK Kolber, J Tom, JG AF Zakikhani, M. Harrelson, D. W. Kissane, J. A. Allis, M. K. Kolber, J. Tom, J. G. BE Lekkas, TD TI MANAGEMENT SOFTWARE FOR PROTECTION OF THE GREAT LAKES COASTAL NAVIGATION AREAS SO PROCEEDINGS OF THE 13TH INTERNATIONAL CONFERENCE ON ENVIRONMENTAL SCIENCE AND TECHNOLOGY SE Proceedings of the International Conference on Environmental Science and Technology LA English DT Proceedings Paper CT 13th International Conference on Environmental Science and Technology (CEST) CY SEP 05-07, 2013 CL Athens, GREECE SP Univ Aegean, Global Network Environm Sci & Technol DE hydrodynamic forces; response of structures; fluid dynamics; armor stone durability; Great Lakes; numerical modelling; laboratory testing AB Protecting harbors or navigable areas requires evaluating maritime structures such as armor stones. Armor rocks are impacted by the natural deteriorating elements such as seasonal weather, and repeated cycles of temperature, flowing water, wetting and drying, wave action, and freeze and thaw cycles. The design process for the determination of armor stone sizes is complex and various factors must be considered to fully understand how the design parameters have effect on stone performance. The main objective of this study was to evaluate and quantify major factors affecting the armor stone durability. The effects of scaling on the test results of various samples of rock types used in Great Lakes coastal projects have been investigated. Field monitoring and laboratory testing have been conducted to evaluate the performance of stone subjected to both freezing and thawing and wetting and drying, and to quantify the combined effects of environmental stresses on armor stone. In addition, long-term performance or deterioration of armor stones have been quantitatively monitored and characterized by the changes in dimensions measured. We have developed stone deterioration software (ARMOR), which integrates field observations with numerical tools to provide an assessment of the local freeze-thaw and wet-dry on the stones. The ARMOR software has several numerical models, which can predict degradation of Armor Stone as rocks are impacted by the natural elements. The software includes a statistical technique (homogeneity index) to characterize rock heterogeneity. Two new numerical approaches have been developed to calculate freeze thaw cycles using long-term site weather data. The software also provides a model to estimate armor weight, minimum crest width, armor thickness, and the number of armor units per unit of area. The calculation uses varying values for the seaward slope and wave height by application of the Hudson formula. The degradation model relates the laboratory test results to the modification of the mass distribution and reduction at the project site. Innovative technologies such as geophysical techniques in stone selection and stonecutting (water saw) are examined for the field applications. This paper describes the latest research developments that improve our understanding of environmental impacts on armor stones in coastal areas with reference to breakage and integrity. C1 [Zakikhani, M.; Harrelson, D. W.; Tom, J. G.] US Army, ERDC, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. [Kissane, J. A.] US Army Corps Engn, Chicago, IL USA. [Allis, M. K.] US Army Corps Engn, Detroit, MI USA. [Kolber, J.] US Army Corps Engn, Buffalo, NY USA. RP Zakikhani, M (reprint author), US Army, ERDC, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM mansour.zakikhani@usace.army.mil NR 9 TC 0 Z9 0 U1 0 U2 0 PU GLOBAL NEST, SECRETARIAT PI ATHENS PA UNIV, AEGEAN, 30, VOULGAROKTONOU STR, ATHENS, GR 114 72, GREECE SN 1106-5516 BN 978-960-7475-51-0 J9 PROC INT CONF ENV SC PY 2013 PG 8 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA BB7WL UT WOS:000346067900036 ER PT J AU Yang, CT Ahn, J Boyd, PM Pridal, DB Remus, JI AF Yang, Chih Ted Ahn, Jungkyu Boyd, Paul M. Pridal, Daniel B. Remus, John I. BE Zhaoyin, W Lee, JHW Jizhang, G Shuyou, C TI Lewis and Clark Reservoir Sedimentation and Flushing Simulations SO PROCEEDINGS OF THE 35TH IAHR WORLD CONGRESS, VOLS I AND II LA English DT Proceedings Paper CT 35th World Congress of the International-Association-for-Hydro-Environment-Engineering-and-Research (IAHR) CY SEP 08-13, 2013 CL Chengdu, PEOPLES R CHINA SP Int Assoc Hydro Environm Engn & Res DE Drawdown flushing; Flushing efficiency; GSTARS computer model; Reservoir sedimentation; Sediment transport; Lewis and Clark Lake AB Lewis and Clark Lake, behind Gavins Point Dam near Yankton, South Dakota, U.S.A., is located on the main stream of the Missouri River. The Lewis and Clark Lake reach extends about 40 km from the Gavins Point dam. Large amount of sediment was supplied from a major tributary, the Niobrara River. Reservoir delta has been growing since the closure of Gavins Point dam in 1955 and has resulted in a 21% reduction of storage in 2007. Among several sediment management methods, flushing with water surface drop is a suitable management technique for the lake. The engineering viability of removing sediments deposited in the lake should be examined by numerical modeling before implementing a flushing. GSTARS4 (Yang and Ahn, 2011) was used for this study and calibrated with measured historic data from 1975 to 1995. Channel geometric changes and amount of flushed sediment were predicted with four hypothetical flow scenarios. The flushing efficiencies of all scenarios were estimated by comparing the ratios between water consumption and flushed sediment. C1 [Yang, Chih Ted] Colorado State Univ, Hydrosci & Training Ctr, Civil & Environm Engn Dept, Ft Collins, CO 80523 USA. [Ahn, Jungkyu] Seoul Natl Univ, Civil & Environm Engn Dept, Seoul, South Korea. [Boyd, Paul M.] US Army Corps Engn, Omaha, NE USA. [Pridal, Daniel B.] US Army Corps Engn, Sedimentat & Channel Stabilizat Sect, Omaha, NE USA. [Remus, John I.] Hydrol Engn Branch, Omaha, NE USA. RP Yang, CT (reprint author), Colorado State Univ, Hydrosci & Training Ctr, Civil & Environm Engn Dept, Ft Collins, CO 80523 USA. EM ctyang@engr.colostate.edu; ajk38317@naver.com NR 8 TC 0 Z9 0 U1 2 U2 2 PU TSINGHUA UNIV PI BEIJING PA DEPT BUILDING SCI, SCH ARCHITECTURE, SECRETARIAT ISHVAC07, BEIJING, 100084, PEOPLES R CHINA BN 978-7-302-33544-3 PY 2013 BP 19 EP 27 PG 9 WC Engineering, Civil; Water Resources SC Engineering; Water Resources GA BB5EZ UT WOS:000343761500003 ER PT B AU Mendoza, E Cooper, JP Evangelista, JW Auerbach, M Arnas, O AF Mendoza, Eduardo Cooper, Jean-pierre Evangelista, John W. Auerbach, Margaret Arnas, Oezer GP ASME TI ON DEMAND THERMAL PROTECTION (ODTP): A NEW APPROACH FOR DESIGNING GARMENTS EXPOSED TO FLASH FLAME INCIDENTS SO PROCEEDINGS OF THE ASME INTERNATIONAL MECHANICAL ENGINEERING CONGRESS AND EXPOSITION - 2012, VOL 7, PTS A-D LA English DT Proceedings Paper CT ASME International Mechanical Engineering Congress and Exposition CY NOV 09-15, 2012 CL Houston, TX SP ASME ID OPERATIONS; COMBAT; BURNS AB Soldiers, first responders and other high risk occupations such as power line technicians are routinely exposed to dangerous situations where severe burn injuries are possible. Standard flame resistant (FR) fabrics provide minimal burn protection when. exposed to a flash flame incident; As a result, improvement in thermal protection is desperately needed and remains an ongoing subject of research and development. A simplified one dimensional physical model composed of a muscle layer, skin/fat layer, air gap(s) and fabric layer(s) is used to model heat transfer entering the body covered by a garment that is exposed to a flash flame. Heat transfer within the skin and muscle layers is modeled by combined conduction, metabolic heat generation and blood perfusion by a recently developed modification to the heat equation termed the bio-heat equation. Boundary conditions include a fixed temperature (core body temperature) at the inside of the muscle layer and combined convection and radiation from the flame on the outside of the fabric. The heat equation is solved by discretizing the domain in one dimension and using a finite volume approach to derive the finite difference equations. This model is an initial step to be used to provide an assessment of common FR garments with respect to both comfort in ambient conditions and protection during a flash flame. It also provides for parametric analysis to determine ideal thermo-physical properties, fabric thicknesses and layering for better protection during flash flame incidents. Estimates for time to burn injury from the numerical model is presented with experimental results using live mannequin flame tests (ASTMF-1930), standard vertical flame tests (ISO-17492) and a non-standard flame test with combined convection and radiation heat fluxes up to 85 kW/m(2). The main effort of this study revolves around an initial working design for a dynamic garment termed On Demand Thermal Protection (ODTP). The primary focus of the design is the development of a thermistor circuit embedded in a protective garment to act as an electric sensor for rapidly deploying the necessary thermal protection that is needed as predicted by the numerical model instantaneously in the event of a flash flame incident. An initial prototype is being developed with a focus on designing the thermistor circuit to mechanically actuate protective components in a flash-flame environment. Concepts include rapidly releasing a pressurized flame retardant fluid through vinyl tubing sewn into a garment and deploying a protective barrier around the face and neck when the thermistor circuit detects a sudden change in heat transfer. A summary of the prototype along with experimental testing to date compared to the theoretical predictions from the model described above is presented. C1 [Mendoza, Eduardo; Cooper, Jean-pierre; Evangelista, John W.; Arnas, Oezer] US Mil Acad, Dept Civil & Mech Engn, West Point, NY 10996 USA. [Auerbach, Margaret] US Army, NSRDEC, Natick, MA 01760 USA. RP Mendoza, E (reprint author), US Mil Acad, Dept Civil & Mech Engn, West Point, NY 10996 USA. NR 6 TC 0 Z9 0 U1 0 U2 5 PU AMER SOC MECHANICAL ENGINEERS PI NEW YORK PA THREE PARK AVENUE, NEW YORK, NY 10016-5990 USA BN 978-0-7918-4523-3 PY 2013 BP 2111 EP 2120 PG 10 WC Engineering, Mechanical SC Engineering GA BC1GH UT WOS:000350071100238 ER PT B AU Coletti, F Benson, MJ Sagues, AL Miller, BH Fahrig, R Eaton, JK AF Coletti, Filippo Benson, Michael J. Sagues, Alexander L. Miller, Benjamin H. Fahrig, Rebecca Eaton, John K. GP ASME TI THREE-DIMENSIONAL MASS FRACTION DISTRIBUTION OF A SPRAY MEASURED BY X-RAY COMPUTED TOMOGRAPHY SO PROCEEDINGS OF THE ASME TURBO EXPO: TURBINE TECHNICAL CONFERENCE AND EXPOSITION, 2013, VOL 1B LA English DT Proceedings Paper CT ASME Turbo Expo: Turbine Technical Conference and Exposition CY JUN 03-07, 2013 CL San Antonio, TX SP Int Gas Turbine Inst ID FUEL SPRAYS; RADIOGRAPHY; MECHANICS AB In order to design a spraying system with the desired characteristics, the atomization process has to be understood in detail, including the primary break-up of the liquid core. Accurate prediction of primary break-up is a major barrier to computer-based analysis of spray combustion. The development of models is hindered by the lack of validation data in a region where the fluid is dense, and optical access is therefore limited. The present experimental study is aimed at probing the spray structure by means of X-ray computed tomography (CT). A full-cone atomizer (0.79 mm orifice diameter) spraying in air at ambient pressure is investigated as a proof of concept. A mixture of water and iodine is used as the working fluid, providing elevated X-ray absorption and therefore improved signal-to-noise ratio. Several hundreds of X-ray projections are acquired as the spraying atomizer is rotated in front of the detector. Standard software for medical imaging is used to reconstruct the three-dimensional time-averaged distribution of liquid mass fraction in the full field of view, from the intact liquid core to the dilute spray region. A spatial resolution of 0.6 mm is obtained along the spraying direction, while the resolution is 0.3 mm in the other two directions. Significant asymmetries in the structure of the spray are revealed. C1 [Coletti, Filippo; Eaton, John K.] Stanford Univ, Dept Mech Engn, Stanford, CA 94305 USA. [Benson, Michael J.] US Mil Acad, Dept Civil & Mech Engn, West Point, NY 10996 USA. [Sagues, Alexander L.; Miller, Benjamin H.] US Mil Acad, West Point, NY 10996 USA. [Fahrig, Rebecca] Stanford Univ, Dept Radiol, Stanford, CA 94305 USA. RP Coletti, F (reprint author), Stanford Univ, Dept Mech Engn, Stanford, CA 94305 USA. EM colettif@stanford.edu; michael.benson@usma.edu; Alexander.Sanues@usma.edu; Benjamin.Miller@usma.edu; fahrig@stanford.edu; eatonj@stanford.edu NR 27 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC MECHANICAL ENGINEERS PI NEW YORK PA THREE PARK AVENUE, NEW YORK, NY 10016-5990 USA BN 978-0-7918-5511-9 PY 2013 AR UNSP V002T04A033 PG 11 WC Engineering, Mechanical SC Engineering GA BD5DU UT WOS:000361341000033 ER PT B AU Ling, JL Elkins, CJ Benson, MJ Yapa, SD Eaton, JK AF Ling, Julia Elkins, Christopher J. Benson, Michael J. Yapa, Sayuri D. Eaton, John K. GP ASME TI MEASUREMENTS OF A TRAILING EDGE SLOT FILM COOLING GEOMETRY DESIGNED FOR REDUCED COOLANT FLOWRATE AND HIGH SURFACE EFFECTIVENESS SO PROCEEDINGS OF THE ASME TURBO EXPO: TURBINE TECHNICAL CONFERENCE AND EXPOSITION, 2013, VOL 3B LA English DT Proceedings Paper CT ASME Turbo Expo: Turbine Technical Conference and Exposition CY JUN 03-07, 2013 CL San Antonio, TX SP Int Gas Turbine Inst ID CUTBACK; LAYER AB A trailing edge slot film cooling configuration designed for enhanced surface effectiveness at a decreased coolant flowrate is proposed. Magnetic resonance imaging (MRI) techniques were used to obtain measurements of the mean 3D velocity and concentration fields. These measurements are compared to previously reported results on two other trailing edge configurations. The surface effectiveness of the proposed slot film cooling configuration is higher than that of the baseline configuration, even at a 25% lower coolant flowrate. The mean fields are used to calculate an isotropic, spatially-varying turbulent diffusivity for each of these trailing edge configurations. These diffusivities are compared to offer insight into the effect of land shape on turbulence properties. C1 [Ling, Julia; Elkins, Christopher J.; Yapa, Sayuri D.; Eaton, John K.] Stanford Univ, Stanford, CA 94305 USA. [Benson, Michael J.] US Mil Acad, West Point, NY 10996 USA. RP Ling, JL (reprint author), Stanford Univ, Stanford, CA 94305 USA. EM julial@stanford.edu NR 23 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC MECHANICAL ENGINEERS PI NEW YORK PA THREE PARK AVENUE, NEW YORK, NY 10016-5990 USA BN 978-0-7918-5515-7 PY 2013 AR V03BT13A009 PG 11 WC Thermodynamics; Engineering, Mechanical SC Thermodynamics; Engineering GA BD5GN UT WOS:000361407200027 ER PT J AU Shank, C Patel, CKN Ahearne, JF Back, C Colella, P Dahlburg, J Falcone, R Gupta, Y Haxton, W Hopkins, MD Jeanloz, R Kammerdiener, J Martin, W Murnane, M Nickell, RE Peddicord, K Peercy, PS Rollett, A Rosner, R Selden, R Shea, K Sullivan, F Was, G Yelick, K Shaw, A Rowberg, R McGee, JP Weidman, S Hamilton, L Whitaker, E Lyons, JW Canizares, CR Corotis, RB Francisco, JS Gear, CW Hatch, HJ Lanzerotti, LJ Reichmanis, E Schwartz, LH Shank, CV Streit, DC McGee, J Mozhi, A Butner, C AF Shank, Charles Patel, C. Kumar N. Ahearne, John F. Back, Christina Colella, Phillip Dahlburg, Jill Falcone, Roger Gupta, Yogendra Haxton, Wick Hopkins, Michael D. Jeanloz, Raymond Kammerdiener, John Martin, William Murnane, Margaret Nickell, Robert E. Peddicord, Kenneth Peercy, Paul S. Rollett, Anthony Rosner, Robert Selden, Robert Shea, Kenneth Sullivan, Francis Was, Gary Yelick, Katherine Shaw, Alan Rowberg, Richard McGee, James P. Weidman, Scott Hamilton, Liza Whitaker, Eric Lyons, John W. Canizares, Claude R. Corotis, Ross B. Francisco, Joseph S. Gear, C. William Hatch, Henry J. Lanzerotti, Louis J. Reichmanis, Elsa Schwartz, Lyle H. Shank, Charles V. Streit, Dwight C. McGee, James Mozhi, Arul Butner, Cy CA Dept Energy Lab Assessments Board Div Engn Phys Sci Natl Acad GP Natl Res Council TI The Quality of Science and Engineering at the NNSA National Security Laboratories Summary SO QUALITY OF SCIENCE AND ENGINEERING AT THE NNSA NATIONAL SECURITY LABORATORIES LA English DT Editorial Material; Book Chapter C1 [Shank, Charles; Shank, Charles V.] Howard Hughes Med Inst, New Haven, CT 06510 USA. [Patel, C. Kumar N.] Pranalytica Inc, Santa Monica, CA USA. [Ahearne, John F.] Sigma Xi, Res Triangle Pk, NC USA. [Back, Christina] Gen Atom Co, San Diego, CA 92138 USA. [Colella, Phillip; Yelick, Katherine] Lawrence Berkeley Natl Lab, Berkeley, CA USA. [Dahlburg, Jill] Naval Res Lab, Washington, DC 20375 USA. [Falcone, Roger; Haxton, Wick; Jeanloz, Raymond] Univ Calif Berkeley, Berkeley, CA 94720 USA. [Gupta, Yogendra] Washington State Univ, Pullman, WA 99164 USA. [Hopkins, Michael D.; Rosner, Robert] Univ Chicago, Chicago, IL 60637 USA. [Martin, William; Was, Gary] Univ Michigan, Ann Arbor, MI 48109 USA. [Murnane, Margaret; Corotis, Ross B.] Univ Colorado, Boulder, CO 80309 USA. [Peddicord, Kenneth] Texas A&M Univ, College Stn, TX 77843 USA. [Peercy, Paul S.] Univ Wisconsin, Madison, WI 53706 USA. [Rollett, Anthony] Carnegie Mellon Univ, Pittsburgh, PA 15213 USA. [Shea, Kenneth] Univ Calif Irvine, Irvine, CA USA. [Lyons, John W.] US Army Res Lab, Los Angeles, CA USA. [Canizares, Claude R.] MIT, Cambridge, MA 02139 USA. [Francisco, Joseph S.] Purdue Univ, W Lafayette, IN 47907 USA. [Gear, C. William] Univ Illinois, Urbana, IL 61801 USA. [Hatch, Henry J.] US Army, Los Angeles, CA USA. [Lanzerotti, Louis J.] New Jersey Inst Technol, Newark, NJ 07102 USA. [Reichmanis, Elsa] Georgia Inst Technol, Atlanta, GA 30332 USA. [Schwartz, Lyle H.] Air Force Off Sci Res, Los Angeles, CA USA. [Streit, Dwight C.] Univ Calif Los Angeles, Los Angeles, CA USA. RP Shank, C (reprint author), Howard Hughes Med Inst, New Haven, CT 06510 USA. NR 4 TC 0 Z9 0 U1 0 U2 0 PU NATL ACADEMIES PRESS PI WASHINGTON PA 2101 CONSTITUTION AVE, WASHINGTON, DC 20418 USA BN 978-0-309-29090-6 PY 2013 BP 1 EP 7 PG 7 WC Engineering, Multidisciplinary SC Engineering GA BC9BO UT WOS:000356274800001 ER PT J AU Shank, C Patel, CKN Ahearne, JF Back, C Colella, P Dahlburg, J Falcone, R Gupta, Y Haxton, W Hopkins, MD Jeanloz, R Kammerdiener, J Martin, W Murnane, M Nickell, RE Peddicord, K Peercy, PS Rollett, A Rosner, R Selden, R Shea, K Sullivan, F Was, G Yelick, K Shaw, A Rowberg, R McGee, JP Weidman, S Hamilton, L Whitaker, E Lyons, JW Canizares, CR Corotis, RB Francisco, JS Gear, CW Hatch, HJ Lanzerotti, LJ Reichmanis, E Schwartz, LH Shank, CV Streit, DC McGee, J Mozhi, A Butner, C AF Shank, Charles Patel, C. Kumar N. Ahearne, John F. Back, Christina Colella, Phillip Dahlburg, Jill Falcone, Roger Gupta, Yogendra Haxton, Wick Hopkins, Michael D. Jeanloz, Raymond Kammerdiener, John Martin, William Murnane, Margaret Nickell, Robert E. Peddicord, Kenneth Peercy, Paul S. Rollett, Anthony Rosner, Robert Selden, Robert Shea, Kenneth Sullivan, Francis Was, Gary Yelick, Katherine Shaw, Alan Rowberg, Richard McGee, James P. Weidman, Scott Hamilton, Liza Whitaker, Eric Lyons, John W. Canizares, Claude R. Corotis, Ross B. Francisco, Joseph S. Gear, C. William Hatch, Henry J. Lanzerotti, Louis J. Reichmanis, Elsa Schwartz, Lyle H. Shank, Charles V. Streit, Dwight C. McGee, James Mozhi, Arul Butner, Cy CA Dept Energy Lab Assessments Board Div Engn Phys Sci Natl Acad GP Natl Res Council TI The Quality of Science and Engineering at the NNSA National Security Laboratories Introduction SO QUALITY OF SCIENCE AND ENGINEERING AT THE NNSA NATIONAL SECURITY LABORATORIES LA English DT Editorial Material; Book Chapter C1 [Shank, Charles; Shank, Charles V.] Howard Hughes Med Inst, New Haven, CT 06510 USA. [Patel, C. Kumar N.] Pranalytica Inc, Santa Monica, CA USA. [Ahearne, John F.] Sigma Xi, Res Triangle Pk, NC USA. [Back, Christina] Gen Atom Co, San Diego, CA 92138 USA. [Colella, Phillip; Yelick, Katherine] Lawrence Berkeley Natl Lab, Berkeley, CA USA. [Dahlburg, Jill] Naval Res Lab, Washington, DC 20375 USA. [Falcone, Roger; Haxton, Wick; Jeanloz, Raymond] Univ Calif Berkeley, Berkeley, CA 94720 USA. [Gupta, Yogendra] Washington State Univ, Pullman, WA 99164 USA. [Hopkins, Michael D.; Rosner, Robert] Univ Chicago, Chicago, IL 60637 USA. [Martin, William; Was, Gary] Univ Michigan, Ann Arbor, MI 48109 USA. [Murnane, Margaret; Corotis, Ross B.] Univ Colorado, Boulder, CO 80309 USA. [Peddicord, Kenneth] Texas A&M Univ, College Stn, TX 77843 USA. [Peercy, Paul S.] Univ Wisconsin, Madison, WI 53706 USA. [Rollett, Anthony] Carnegie Mellon Univ, Pittsburgh, PA 15213 USA. [Shea, Kenneth] Univ Calif Irvine, Irvine, CA USA. [Lyons, John W.] US Army Res Lab, Los Angeles, CA USA. [Canizares, Claude R.] MIT, Cambridge, MA 02139 USA. [Francisco, Joseph S.] Purdue Univ, W Lafayette, IN 47907 USA. [Gear, C. William] Univ Illinois, Urbana, IL 61801 USA. [Hatch, Henry J.] US Army, Los Angeles, CA USA. [Lanzerotti, Louis J.] New Jersey Inst Technol, Newark, NJ 07102 USA. [Reichmanis, Elsa] Georgia Inst Technol, Atlanta, GA 30332 USA. [Schwartz, Lyle H.] Air Force Off Sci Res, Los Angeles, CA USA. [Streit, Dwight C.] Univ Calif Los Angeles, Los Angeles, CA USA. RP Shank, C (reprint author), Howard Hughes Med Inst, New Haven, CT 06510 USA. NR 2 TC 0 Z9 0 U1 0 U2 0 PU NATL ACADEMIES PRESS PI WASHINGTON PA 2101 CONSTITUTION AVE, WASHINGTON, DC 20418 USA BN 978-0-309-29090-6 PY 2013 BP 8 EP 12 PG 5 WC Engineering, Multidisciplinary SC Engineering GA BC9BO UT WOS:000356274800002 ER PT J AU Shank, C Patel, CKN Ahearne, JF Back, C Colella, P Dahlburg, J Falcone, R Gupta, Y Haxton, W Hopkins, MD Jeanloz, R Kammerdiener, J Martin, W Murnane, M Nickell, RE Peddicord, K Peercy, PS Rollett, A Rosner, R Selden, R Shea, K Sullivan, F Was, G Yelick, K Shaw, A Rowberg, R McGee, JP Weidman, S Hamilton, L Whitaker, E Lyons, JW Canizares, CR Corotis, RB Francisco, JS Gear, CW Hatch, HJ Lanzerotti, LJ Reichmanis, E Schwartz, LH Shank, CV Streit, DC McGee, J Mozhi, A Butner, C AF Shank, Charles Patel, C. Kumar N. Ahearne, John F. Back, Christina Colella, Phillip Dahlburg, Jill Falcone, Roger Gupta, Yogendra Haxton, Wick Hopkins, Michael D. Jeanloz, Raymond Kammerdiener, John Martin, William Murnane, Margaret Nickell, Robert E. Peddicord, Kenneth Peercy, Paul S. Rollett, Anthony Rosner, Robert Selden, Robert Shea, Kenneth Sullivan, Francis Was, Gary Yelick, Katherine Shaw, Alan Rowberg, Richard McGee, James P. Weidman, Scott Hamilton, Liza Whitaker, Eric Lyons, John W. Canizares, Claude R. Corotis, Ross B. Francisco, Joseph S. Gear, C. William Hatch, Henry J. Lanzerotti, Louis J. Reichmanis, Elsa Schwartz, Lyle H. Shank, Charles V. Streit, Dwight C. McGee, James Mozhi, Arul Butner, Cy CA Dept Energy Lab Assessments Board Div Engn Phys Sci Natl Acad GP Natl Res Council TI Nuclear Weapons Design SO QUALITY OF SCIENCE AND ENGINEERING AT THE NNSA NATIONAL SECURITY LABORATORIES LA English DT Article; Book Chapter C1 [Shank, Charles; Shank, Charles V.] Howard Hughes Med Inst, New Haven, CT 06510 USA. [Patel, C. Kumar N.] Pranalytica Inc, Santa Monica, CA USA. [Ahearne, John F.] Sigma Xi, Res Triangle Pk, NC USA. [Back, Christina] Gen Atom Co, San Diego, CA 92138 USA. [Colella, Phillip; Yelick, Katherine] Lawrence Berkeley Natl Lab, Berkeley, CA USA. [Dahlburg, Jill] Naval Res Lab, Washington, DC 20375 USA. [Falcone, Roger; Haxton, Wick; Jeanloz, Raymond] Univ Calif Berkeley, Berkeley, CA 94720 USA. [Gupta, Yogendra] Washington State Univ, Pullman, WA 99164 USA. [Hopkins, Michael D.; Rosner, Robert] Univ Chicago, Chicago, IL 60637 USA. [Martin, William; Was, Gary] Univ Michigan, Ann Arbor, MI 48109 USA. [Murnane, Margaret; Corotis, Ross B.] Univ Colorado, Boulder, CO 80309 USA. [Peddicord, Kenneth] Texas A&M Univ, College Stn, TX 77843 USA. [Peercy, Paul S.] Univ Wisconsin, Madison, WI 53706 USA. [Rollett, Anthony] Carnegie Mellon Univ, Pittsburgh, PA 15213 USA. [Shea, Kenneth] Univ Calif Irvine, Irvine, CA USA. [Lyons, John W.] US Army Res Lab, Los Angeles, CA USA. [Canizares, Claude R.] MIT, Cambridge, MA 02139 USA. [Francisco, Joseph S.] Purdue Univ, W Lafayette, IN 47907 USA. [Gear, C. William] Univ Illinois, Urbana, IL 61801 USA. [Hatch, Henry J.] US Army, Los Angeles, CA USA. [Lanzerotti, Louis J.] New Jersey Inst Technol, Newark, NJ 07102 USA. [Reichmanis, Elsa] Georgia Inst Technol, Atlanta, GA 30332 USA. [Schwartz, Lyle H.] Air Force Off Sci Res, Los Angeles, CA USA. [Streit, Dwight C.] Univ Calif Los Angeles, Los Angeles, CA USA. RP Shank, C (reprint author), Howard Hughes Med Inst, New Haven, CT 06510 USA. NR 4 TC 0 Z9 0 U1 2 U2 2 PU NATL ACADEMIES PRESS PI WASHINGTON PA 2101 CONSTITUTION AVE, WASHINGTON, DC 20418 USA BN 978-0-309-29090-6 PY 2013 BP 13 EP 18 PG 6 WC Engineering, Multidisciplinary SC Engineering GA BC9BO UT WOS:000356274800003 ER PT J AU Shank, C Patel, CKN Ahearne, JF Back, C Colella, P Dahlburg, J Falcone, R Gupta, Y Haxton, W Hopkins, MD Jeanloz, R Kammerdiener, J Martin, W Murnane, M Nickell, RE Peddicord, K Peercy, PS Rollett, A Rosner, R Selden, R Shea, K Sullivan, F Was, G Yelick, K Shaw, A Rowberg, R McGee, JP Weidman, S Hamilton, L Whitaker, E Lyons, JW Canizares, CR Corotis, RB Francisco, JS Gear, CW Hatch, HJ Lanzerotti, LJ Reichmanis, E Schwartz, LH Shank, CV Streit, DC McGee, J Mozhi, A Butner, C AF Shank, Charles Patel, C. Kumar N. Ahearne, John F. Back, Christina Colella, Phillip Dahlburg, Jill Falcone, Roger Gupta, Yogendra Haxton, Wick Hopkins, Michael D. Jeanloz, Raymond Kammerdiener, John Martin, William Murnane, Margaret Nickell, Robert E. Peddicord, Kenneth Peercy, Paul S. Rollett, Anthony Rosner, Robert Selden, Robert Shea, Kenneth Sullivan, Francis Was, Gary Yelick, Katherine Shaw, Alan Rowberg, Richard McGee, James P. Weidman, Scott Hamilton, Liza Whitaker, Eric Lyons, John W. Canizares, Claude R. Corotis, Ross B. Francisco, Joseph S. Gear, C. William Hatch, Henry J. Lanzerotti, Louis J. Reichmanis, Elsa Schwartz, Lyle H. Shank, Charles V. Streit, Dwight C. McGee, James Mozhi, Arul Butner, Cy CA Dept Energy Lab Assessments Board Div Engn Phys Sci Natl Acad GP Natl Res Council TI Systems Engineering and Aging SO QUALITY OF SCIENCE AND ENGINEERING AT THE NNSA NATIONAL SECURITY LABORATORIES LA English DT Article; Book Chapter C1 [Shank, Charles; Shank, Charles V.] Howard Hughes Med Inst, New Haven, CT 06510 USA. [Patel, C. Kumar N.] Pranalytica Inc, Santa Monica, CA USA. [Ahearne, John F.] Sigma Xi, Res Triangle Pk, NC USA. [Back, Christina] Gen Atom Co, San Diego, CA 92138 USA. [Colella, Phillip; Yelick, Katherine] Lawrence Berkeley Natl Lab, Berkeley, CA USA. [Dahlburg, Jill] Naval Res Lab, Washington, DC 20375 USA. [Falcone, Roger; Haxton, Wick; Jeanloz, Raymond] Univ Calif Berkeley, Berkeley, CA 94720 USA. [Gupta, Yogendra] Washington State Univ, Pullman, WA 99164 USA. [Hopkins, Michael D.; Rosner, Robert] Univ Chicago, Chicago, IL 60637 USA. [Martin, William; Was, Gary] Univ Michigan, Ann Arbor, MI 48109 USA. [Murnane, Margaret; Corotis, Ross B.] Univ Colorado, Boulder, CO 80309 USA. [Peddicord, Kenneth] Texas A&M Univ, College Stn, TX 77843 USA. [Peercy, Paul S.] Univ Wisconsin, Madison, WI 53706 USA. [Rollett, Anthony] Carnegie Mellon Univ, Pittsburgh, PA 15213 USA. [Shea, Kenneth] Univ Calif Irvine, Irvine, CA USA. [Lyons, John W.] US Army Res Lab, Los Angeles, CA USA. [Canizares, Claude R.] MIT, Cambridge, MA 02139 USA. [Francisco, Joseph S.] Purdue Univ, W Lafayette, IN 47907 USA. [Gear, C. William] Univ Illinois, Urbana, IL 61801 USA. [Hatch, Henry J.] US Army, Los Angeles, CA USA. [Lanzerotti, Louis J.] New Jersey Inst Technol, Newark, NJ 07102 USA. [Reichmanis, Elsa] Georgia Inst Technol, Atlanta, GA 30332 USA. [Schwartz, Lyle H.] Air Force Off Sci Res, Los Angeles, CA USA. [Streit, Dwight C.] Univ Calif Los Angeles, Los Angeles, CA USA. RP Shank, C (reprint author), Howard Hughes Med Inst, New Haven, CT 06510 USA. NR 4 TC 0 Z9 0 U1 0 U2 0 PU NATL ACADEMIES PRESS PI WASHINGTON PA 2101 CONSTITUTION AVE, WASHINGTON, DC 20418 USA BN 978-0-309-29090-6 PY 2013 BP 19 EP 25 PG 7 WC Engineering, Multidisciplinary SC Engineering GA BC9BO UT WOS:000356274800004 ER PT J AU Shank, C Patel, CKN Ahearne, JF Back, C Colella, P Dahlburg, J Falcone, R Gupta, Y Haxton, W Hopkins, MD Jeanloz, R Kammerdiener, J Martin, W Murnane, M Nickell, RE Peddicord, K Peercy, PS Rollett, A Rosner, R Selden, R Shea, K Sullivan, F Was, G Yelick, K Shaw, A Rowberg, R McGee, JP Weidman, S Hamilton, L Whitaker, E Lyons, JW Canizares, CR Corotis, RB Francisco, JS Gear, CW Hatch, HJ Lanzerotti, LJ Reichmanis, E Schwartz, LH Shank, CV Streit, DC McGee, J Mozhi, A Butner, C AF Shank, Charles Patel, C. Kumar N. Ahearne, John F. Back, Christina Colella, Phillip Dahlburg, Jill Falcone, Roger Gupta, Yogendra Haxton, Wick Hopkins, Michael D. Jeanloz, Raymond Kammerdiener, John Martin, William Murnane, Margaret Nickell, Robert E. Peddicord, Kenneth Peercy, Paul S. Rollett, Anthony Rosner, Robert Selden, Robert Shea, Kenneth Sullivan, Francis Was, Gary Yelick, Katherine Shaw, Alan Rowberg, Richard McGee, James P. Weidman, Scott Hamilton, Liza Whitaker, Eric Lyons, John W. Canizares, Claude R. Corotis, Ross B. Francisco, Joseph S. Gear, C. William Hatch, Henry J. Lanzerotti, Louis J. Reichmanis, Elsa Schwartz, Lyle H. Shank, Charles V. Streit, Dwight C. McGee, James Mozhi, Arul Butner, Cy CA Dept Energy Lab Assessments Board Div Engn Phys Sci Natl Acad GP Natl Res Council TI The Science Base SO QUALITY OF SCIENCE AND ENGINEERING AT THE NNSA NATIONAL SECURITY LABORATORIES LA English DT Article; Book Chapter C1 [Shank, Charles; Shank, Charles V.] Howard Hughes Med Inst, New Haven, CT 06510 USA. [Patel, C. Kumar N.] Pranalytica Inc, Santa Monica, CA USA. [Ahearne, John F.] Sigma Xi, Res Triangle Pk, NC USA. [Back, Christina] Gen Atom Co, San Diego, CA 92138 USA. [Colella, Phillip; Yelick, Katherine] Lawrence Berkeley Natl Lab, Berkeley, CA USA. [Dahlburg, Jill] Naval Res Lab, Washington, DC 20375 USA. [Falcone, Roger; Haxton, Wick; Jeanloz, Raymond] Univ Calif Berkeley, Berkeley, CA 94720 USA. [Gupta, Yogendra] Washington State Univ, Pullman, WA 99164 USA. [Hopkins, Michael D.; Rosner, Robert] Univ Chicago, Chicago, IL 60637 USA. [Martin, William; Was, Gary] Univ Michigan, Ann Arbor, MI 48109 USA. [Murnane, Margaret; Corotis, Ross B.] Univ Colorado, Boulder, CO 80309 USA. [Peddicord, Kenneth] Texas A&M Univ, College Stn, TX 77843 USA. [Peercy, Paul S.] Univ Wisconsin, Madison, WI 53706 USA. [Rollett, Anthony] Carnegie Mellon Univ, Pittsburgh, PA 15213 USA. [Shea, Kenneth] Univ Calif Irvine, Irvine, CA USA. [Lyons, John W.] US Army Res Lab, Los Angeles, CA USA. [Canizares, Claude R.] MIT, Cambridge, MA 02139 USA. [Francisco, Joseph S.] Purdue Univ, W Lafayette, IN 47907 USA. [Gear, C. William] Univ Illinois, Urbana, IL 61801 USA. [Hatch, Henry J.] US Army, Los Angeles, CA USA. [Lanzerotti, Louis J.] New Jersey Inst Technol, Newark, NJ 07102 USA. [Reichmanis, Elsa] Georgia Inst Technol, Atlanta, GA 30332 USA. [Schwartz, Lyle H.] Air Force Off Sci Res, Los Angeles, CA USA. [Streit, Dwight C.] Univ Calif Los Angeles, Los Angeles, CA USA. RP Shank, C (reprint author), Howard Hughes Med Inst, New Haven, CT 06510 USA. NR 5 TC 0 Z9 0 U1 0 U2 1 PU NATL ACADEMIES PRESS PI WASHINGTON PA 2101 CONSTITUTION AVE, WASHINGTON, DC 20418 USA BN 978-0-309-29090-6 PY 2013 BP 26 EP 36 PG 11 WC Engineering, Multidisciplinary SC Engineering GA BC9BO UT WOS:000356274800005 ER PT J AU Shank, C Patel, CKN Ahearne, JF Back, C Colella, P Dahlburg, J Falcone, R Gupta, Y Haxton, W Hopkins, MD Jeanloz, R Kammerdiener, J Martin, W Murnane, M Nickell, RE Peddicord, K Peercy, PS Rollett, A Rosner, R Selden, R Shea, K Sullivan, F Was, G Yelick, K Shaw, A Rowberg, R McGee, JP Weidman, S Hamilton, L Whitaker, E Lyons, JW Canizares, CR Corotis, RB Francisco, JS Gear, CW Hatch, HJ Lanzerotti, LJ Reichmanis, E Schwartz, LH Shank, CV Streit, DC McGee, J Mozhi, A Butner, C AF Shank, Charles Patel, C. Kumar N. Ahearne, John F. Back, Christina Colella, Phillip Dahlburg, Jill Falcone, Roger Gupta, Yogendra Haxton, Wick Hopkins, Michael D. Jeanloz, Raymond Kammerdiener, John Martin, William Murnane, Margaret Nickell, Robert E. Peddicord, Kenneth Peercy, Paul S. Rollett, Anthony Rosner, Robert Selden, Robert Shea, Kenneth Sullivan, Francis Was, Gary Yelick, Katherine Shaw, Alan Rowberg, Richard McGee, James P. Weidman, Scott Hamilton, Liza Whitaker, Eric Lyons, John W. Canizares, Claude R. Corotis, Ross B. Francisco, Joseph S. Gear, C. William Hatch, Henry J. Lanzerotti, Louis J. Reichmanis, Elsa Schwartz, Lyle H. Shank, Charles V. Streit, Dwight C. McGee, James Mozhi, Arul Butner, Cy CA Dept Energy Lab Assessments Board Div Engn Phys Sci Natl Acad GP Natl Res Council TI Modeling and Simulation SO QUALITY OF SCIENCE AND ENGINEERING AT THE NNSA NATIONAL SECURITY LABORATORIES LA English DT Article; Book Chapter C1 [Shank, Charles; Shank, Charles V.] Howard Hughes Med Inst, New Haven, CT 06510 USA. [Patel, C. Kumar N.] Pranalytica Inc, Santa Monica, CA USA. [Ahearne, John F.] Sigma Xi, Res Triangle Pk, NC USA. [Back, Christina] Gen Atom Co, San Diego, CA 92138 USA. [Colella, Phillip; Yelick, Katherine] Lawrence Berkeley Natl Lab, Berkeley, CA USA. [Dahlburg, Jill] Naval Res Lab, Washington, DC 20375 USA. [Falcone, Roger; Haxton, Wick; Jeanloz, Raymond] Univ Calif Berkeley, Berkeley, CA 94720 USA. [Gupta, Yogendra] Washington State Univ, Pullman, WA 99164 USA. [Hopkins, Michael D.; Rosner, Robert] Univ Chicago, Chicago, IL 60637 USA. [Martin, William; Was, Gary] Univ Michigan, Ann Arbor, MI 48109 USA. [Murnane, Margaret; Corotis, Ross B.] Univ Colorado, Boulder, CO 80309 USA. [Peddicord, Kenneth] Texas A&M Univ, College Stn, TX 77843 USA. [Peercy, Paul S.] Univ Wisconsin, Madison, WI 53706 USA. [Rollett, Anthony] Carnegie Mellon Univ, Pittsburgh, PA 15213 USA. [Shea, Kenneth] Univ Calif Irvine, Irvine, CA USA. [Lyons, John W.] US Army Res Lab, Los Angeles, CA USA. [Canizares, Claude R.] MIT, Cambridge, MA 02139 USA. [Francisco, Joseph S.] Purdue Univ, W Lafayette, IN 47907 USA. [Gear, C. William] Univ Illinois, Urbana, IL 61801 USA. [Hatch, Henry J.] US Army, Los Angeles, CA USA. [Lanzerotti, Louis J.] New Jersey Inst Technol, Newark, NJ 07102 USA. [Reichmanis, Elsa] Georgia Inst Technol, Atlanta, GA 30332 USA. [Schwartz, Lyle H.] Air Force Off Sci Res, Los Angeles, CA USA. [Streit, Dwight C.] Univ Calif Los Angeles, Los Angeles, CA USA. RP Shank, C (reprint author), Howard Hughes Med Inst, New Haven, CT 06510 USA. NR 3 TC 0 Z9 0 U1 0 U2 0 PU NATL ACADEMIES PRESS PI WASHINGTON PA 2101 CONSTITUTION AVE, WASHINGTON, DC 20418 USA BN 978-0-309-29090-6 PY 2013 BP 37 EP 44 PG 8 WC Engineering, Multidisciplinary SC Engineering GA BC9BO UT WOS:000356274800006 ER PT J AU Shank, C Patel, CKN Ahearne, JF Back, C Colella, P Dahlburg, J Falcone, R Gupta, Y Haxton, W Hopkins, MD Jeanloz, R Kammerdiener, J Martin, W Murnane, M Nickell, RE Peddicord, K Peercy, PS Rollett, A Rosner, R Selden, R Shea, K Sullivan, F Was, G Yelick, K Shaw, A Rowberg, R McGee, JP Weidman, S Hamilton, L Whitaker, E Lyons, JW Canizares, CR Corotis, RB Francisco, JS Gear, CW Hatch, HJ Lanzerotti, LJ Reichmanis, E Schwartz, LH Shank, CV Streit, DC McGee, J Mozhi, A Butner, C AF Shank, Charles Patel, C. Kumar N. Ahearne, John F. Back, Christina Colella, Phillip Dahlburg, Jill Falcone, Roger Gupta, Yogendra Haxton, Wick Hopkins, Michael D. Jeanloz, Raymond Kammerdiener, John Martin, William Murnane, Margaret Nickell, Robert E. Peddicord, Kenneth Peercy, Paul S. Rollett, Anthony Rosner, Robert Selden, Robert Shea, Kenneth Sullivan, Francis Was, Gary Yelick, Katherine Shaw, Alan Rowberg, Richard McGee, James P. Weidman, Scott Hamilton, Liza Whitaker, Eric Lyons, John W. Canizares, Claude R. Corotis, Ross B. Francisco, Joseph S. Gear, C. William Hatch, Henry J. Lanzerotti, Louis J. Reichmanis, Elsa Schwartz, Lyle H. Shank, Charles V. Streit, Dwight C. McGee, James Mozhi, Arul Butner, Cy CA Dept Energy Lab Assessments Board Div Engn Phys Sci Natl Acad GP Natl Res Council TI Cross-Cutting Themes SO QUALITY OF SCIENCE AND ENGINEERING AT THE NNSA NATIONAL SECURITY LABORATORIES LA English DT Article; Book Chapter C1 [Shank, Charles; Shank, Charles V.] Howard Hughes Med Inst, New Haven, CT 06510 USA. [Patel, C. Kumar N.] Pranalytica Inc, Santa Monica, CA USA. [Ahearne, John F.] Sigma Xi, Res Triangle Pk, NC USA. [Back, Christina] Gen Atom Co, San Diego, CA 92138 USA. [Colella, Phillip; Yelick, Katherine] Lawrence Berkeley Natl Lab, Berkeley, CA USA. [Dahlburg, Jill] Naval Res Lab, Washington, DC 20375 USA. [Falcone, Roger; Haxton, Wick; Jeanloz, Raymond] Univ Calif Berkeley, Berkeley, CA 94720 USA. [Gupta, Yogendra] Washington State Univ, Pullman, WA 99164 USA. [Hopkins, Michael D.; Rosner, Robert] Univ Chicago, Chicago, IL 60637 USA. [Martin, William; Was, Gary] Univ Michigan, Ann Arbor, MI 48109 USA. [Murnane, Margaret; Corotis, Ross B.] Univ Colorado, Boulder, CO 80309 USA. [Peddicord, Kenneth] Texas A&M Univ, College Stn, TX 77843 USA. [Peercy, Paul S.] Univ Wisconsin, Madison, WI 53706 USA. [Rollett, Anthony] Carnegie Mellon Univ, Pittsburgh, PA 15213 USA. [Shea, Kenneth] Univ Calif Irvine, Irvine, CA USA. [Lyons, John W.] US Army Res Lab, Los Angeles, CA USA. [Canizares, Claude R.] MIT, Cambridge, MA 02139 USA. [Francisco, Joseph S.] Purdue Univ, W Lafayette, IN 47907 USA. [Gear, C. William] Univ Illinois, Urbana, IL 61801 USA. [Hatch, Henry J.] US Army, Los Angeles, CA USA. [Lanzerotti, Louis J.] New Jersey Inst Technol, Newark, NJ 07102 USA. [Reichmanis, Elsa] Georgia Inst Technol, Atlanta, GA 30332 USA. [Schwartz, Lyle H.] Air Force Off Sci Res, Los Angeles, CA USA. [Streit, Dwight C.] Univ Calif Los Angeles, Los Angeles, CA USA. RP Shank, C (reprint author), Howard Hughes Med Inst, New Haven, CT 06510 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU NATL ACADEMIES PRESS PI WASHINGTON PA 2101 CONSTITUTION AVE, WASHINGTON, DC 20418 USA BN 978-0-309-29090-6 PY 2013 BP 45 EP 48 PG 4 WC Engineering, Multidisciplinary SC Engineering GA BC9BO UT WOS:000356274800007 ER PT J AU BenDor, T Westervelt, J Song, Y Sexton, JO AF BenDor, Todd Westervelt, James Song, Yan Sexton, Joseph O. TI Modeling park development through regional land use change simulation SO LAND USE POLICY LA English DT Article DE Regional Urban Growth (RUG) model; Park and recreation planning; Urban open space; Level of service; Urban service provision; Urban growth modeling ID OPEN SPACE; URBAN; LOCATION AB Provision of recreational open space is a major factor in determining resident quality of life in cities. However, urban growth and land use change models typically omit park location and allocation issues when simulating changing urban environments. This paper introduces a method for exploring the spatial allocation of urban parks (public, recreational open spaces) given differing municipal and county investment decisions. Park planning literature has established level of service metrics as rough indicators of provision of public park amenities that are useful guides for future park investment decisions within a given jurisdiction. In this study, we create a dynamic-demand location model that simulates political feedback from population growth and LOS metrics to allocate new parklands (similar to 0.5 ha <= neighborhood parks <= similar to 4 ha) in multi-jurisdictional urbanizing regions. We frame parks as a new development type that augments residential development currently driving a version of the Regional Urban Growth (RUG) urban simulation model, an open source, raster-based simulation platform. Our approach allows planners and researchers to explore urban patterns and distributive outcomes associated with different local open space requirements and investment choices. We illustrate this approach under scenarios for the rapidly growing, three-county Raleigh-Durham-Chapel Hill region of North Carolina, USA. We test varying delays in park planning, purchase, and construction, varying maximum park sizes, and the effects of increased investment levels in two jurisdictions within our study area. This model suggests that the most important aspect of successful park planning is the length of the lag time between residential and park development. Perhaps the most successful park planning strategy is to plan parks along with residential areas. (C) 2012 Elsevier Ltd. All rights reserved. C1 [BenDor, Todd; Song, Yan] Univ N Carolina, Dept City & Reg Planning, Chapel Hill, NC 27599 USA. [Westervelt, James] USA, Engineer Res & Dev Ctr, Construct Engn Res Lab, Champaign, IL 61826 USA. [Sexton, Joseph O.] NASA, Goddard Space Flight Ctr, Greenbelt, MD 20771 USA. RP BenDor, T (reprint author), Univ N Carolina, Dept City & Reg Planning, New E Bldg,CB 3140, Chapel Hill, NC 27599 USA. EM bendor@unc.edu; james.d.westervelt@ERDC.usace.army.mil RI BenDor, Todd/E-1375-2016 OI BenDor, Todd/0000-0003-0132-7702 NR 65 TC 9 Z9 9 U1 4 U2 50 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-8377 EI 1873-5754 J9 LAND USE POLICY JI Land Use Pol. PD JAN PY 2013 VL 30 IS 1 BP 1 EP 12 DI 10.1016/j.landusepol.2012.01.012 PG 12 WC Environmental Studies SC Environmental Sciences & Ecology GA 038SC UT WOS:000311193400001 ER PT J AU Criswell, TL Corona, BT Wang, Z Zhou, Y Niu, GG Xu, Y Christ, GJ Soker, S AF Criswell, Tracy L. Corona, Benjamin T. Wang, Zhan Zhou, Yu Niu, Guoguang Xu, Yong Christ, George J. Soker, Shay TI The role of endothelial cells in myofiber differentiation and the vascularization and innervation of bioengineered muscle tissue in vivo SO BIOMATERIALS LA English DT Article DE Angiogenesis; Skeletal muscle; Tissue engineering; Progenitor cells; Fluorescent labeling ID SKELETAL-MUSCLE; GROWTH-FACTOR; STEM-CELL; SATELLITE CELLS; ANGIOGENESIS; REGENERATION; INJURY; REPAIR; EXPRESSION; ARTERIAL AB Musculoskeletal disorders are a major cause of disability and effective treatments are currently lacking. Tissue engineering affords the possibility of new therapies utilizing cells and biomaterials for the recovery of muscle volume and function. A major consideration in skeletal muscle engineering is the integration of a functional vasculature within the regenerating tissue. In this study we employed fluorescent cell labels to track the location and differentiation of co-cultured cells in vivo and in vitro. We first utilized a co-culture of fluorescently labeled endothelial cells (ECs) and muscle progenitor cells (MPCs) to investigate the ability of ECs to enhance muscle tissue formation and vascularization in an in vivo model of bioengineered muscle. Scaffolds that had been seeded with both MPCs and ECs showed significantly greater vascularization, tissue formation and enhanced innervation as compared to scaffolds seeded with MPCs alone. Subsequently, we performed in vitro experiments using a 3-cell type system (ECs, MPCs, and pericytes (PCs)) to demonstrate the utility of fluorescent cell labeling for monitoring cell growth and differentiation. The growth and differentiation of individual cell types was determined using live cell fluorescent microscopy demonstrating the utility of fluorescent labels to monitor tissue organization in real time. (C) 2012 Elsevier Ltd. All rights reserved. C1 [Criswell, Tracy L.; Wang, Zhan; Zhou, Yu; Niu, Guoguang; Christ, George J.; Soker, Shay] Wake Forest Univ, Bowman Gray Sch Med, Wake Forest Inst Regenerat Med, Winston Salem, NC 27157 USA. [Corona, Benjamin T.] USA, Inst Surg Res, Extrem Trauma & Regenerat Med Res Program, Ft Sam Houston, TX 78234 USA. [Xu, Yong] Virginia Tech, Dept Elect & Comp Engn, Blacksburg, VA 24061 USA. RP Soker, S (reprint author), Wake Forest Univ, Bowman Gray Sch Med, Wake Forest Inst Regenerat Med, Med Ctr Blvd, Winston Salem, NC 27157 USA. EM ssoker@wakehealth.edu RI Niu, Guoguang/F-9929-2014 FU U.S. Department of Defense Armed Forces Institute of Regenerative Medicine [USAMRAA AFIRM W81XWH-08-2-0032]; National Institute of Child Health and Human Development FX This work was supported by the U.S. Department of Defense Armed Forces Institute of Regenerative Medicine (USAMRAA AFIRM W81XWH-08-2-0032 to S.S). The neonatal myosin heavy chain, Pax 7 and RyR antibodies (developed by E. Bandman, A. Kawakami, J. Airey and J. Sutko respectively) were obtained from the Developmental Studies Hybridoma Bank developed under the auspices of the National Institute of Child Health and Human Development and maintained by the University of Iowa, Department of Biology (Iowa City, IA). NR 49 TC 14 Z9 14 U1 1 U2 26 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0142-9612 J9 BIOMATERIALS JI Biomaterials PD JAN PY 2013 VL 34 IS 1 BP 140 EP 149 DI 10.1016/j.biomaterials.2012.09.045 PG 10 WC Engineering, Biomedical; Materials Science, Biomaterials SC Engineering; Materials Science GA 043HB UT WOS:000311532400014 PM 23059002 ER PT J AU Poret, JC Sabatini, JJ AF Poret, Jay C. Sabatini, Jesse J. TI Comparison of Barium and Amorphous Boron Pyrotechnics for Green Light Emission SO JOURNAL OF ENERGETIC MATERIALS LA English DT Article DE combustion; green light; pyrotechnic; spectroscopy AB A comparison of green light emission from both barium- and amorphous boron-based pyrotechnics is described. Emission spectra are shown for both the U.S. Army in-service M125A1 green star cluster formulation and an amorphous boron-potassium nitrate-binder formulation. The main peaks of the emission spectra, average dominant wavelength, and average spectral purity of both formulations are given. The role that combustion products play in determining flame temperature and continuum radiation is also discussed. C1 [Poret, Jay C.; Sabatini, Jesse J.] USA, RDECOM ARDEC, Pyrotech Technol & Prototyping Div, Pyrotech Res Dev & Pilot Plant Branch, Picatinny Arsenal, NJ 07806 USA. RP Poret, JC (reprint author), USA, RDECOM ARDEC, Pyrotech Technol & Prototyping Div, Pyrotech Res Dev & Pilot Plant Branch, Bldg 1515, Picatinny Arsenal, NJ 07806 USA. EM jay.poret@us.army.mil FU U.S. Army; Picatinny Arsenal FX The authors thank the U.S. Army and Picatinny Arsenal for funding of this work. NR 14 TC 5 Z9 5 U1 3 U2 15 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA SN 0737-0652 J9 J ENERG MATER JI J. Energ. Mater. PY 2013 VL 31 IS 1 BP 27 EP 34 DI 10.1080/07370652.2011.588301 PG 8 WC Chemistry, Applied; Chemistry, Physical; Engineering, Chemical; Materials Science, Multidisciplinary SC Chemistry; Engineering; Materials Science GA 971RP UT WOS:000306221800002 ER PT J AU Santarpia, JL Pan, YL Hill, SC Baker, N Cottrell, B McKee, L Ratnesar-Shumate, S Pinnick, RG AF Santarpia, Joshua L. Pan, Yong-Le Hill, Steven C. Baker, Neal Cottrell, Brian McKee, Laura Ratnesar-Shumate, Shanna Pinnick, Ronald G. TI Changes in fluorescence spectra of bioaerosols exposed to ozone in a laboratory reaction chamber to simulate atmospheric aging SO OPTICS EXPRESS LA English DT Article ID AMINO-ACID-RESIDUES; BIOLOGICAL AEROSOL; ORGANIC AEROSOL; SERUM-ALBUMIN; AIR; PARTICLES; BACTERIA; TIME; SIZE; SPECTROMETER AB A laboratory system for exposing aerosol particles to ozone and rapidly measuring the subsequent changes in their single-particle fluorescence is reported. The system consists of a rotating drum chamber and a single-particle fluorescence spectrometer (SPFS) utilizing excitation at 263 nm. Measurements made with this system show preliminary results on the ultra-violet laser-induced-fluorescence (UV-LIF) spectra of single aerosolized particles of Yersinia rohdei, and of MS2 (bacteriophage) exposed to ozone. When bioparticles are exposed in the chamber the fluorescence emission peak around 330 nm: i) decreases in intensity relative to that of the 400-550 nm band; and ii) shifts slightly toward shorter-wavelengths (consistent with further drying of the particles). In these experiments, changes were observed at exposures below the US Environmental Protection Agency (EPA) limits for ozone (C) 2012 Optical Society of America C1 [Santarpia, Joshua L.; Baker, Neal; Cottrell, Brian; McKee, Laura; Ratnesar-Shumate, Shanna] Johns Hopkins Univ, Appl Phys Lab, Laurel, MD 20723 USA. [Pan, Yong-Le; Hill, Steven C.; Pinnick, Ronald G.] USA, Res Lab, Adelphi, MD 20783 USA. RP Santarpia, JL (reprint author), Sandia Natl Labs, Albuquerque, NM 87123 USA. EM jsantar@sandia.gov FU Defense Threat Reduction Agency [HDTRA1-10-C-0023]; US Army Research Laboratory mission funds FX This research was supported by the Defense Threat Reduction Agency under contract number HDTRA1-10-C-0023, and by US Army Research Laboratory mission funds. We thank Dr. Sari Paikoff (DTRA) for her support. We thank Susan Wu and Jerry Hahn for growing the bacteria used in this study. NR 64 TC 13 Z9 13 U1 2 U2 33 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1094-4087 J9 OPT EXPRESS JI Opt. Express PD DEC 31 PY 2012 VL 20 IS 28 BP 29867 EP 29881 DI 10.1364/OE.20.029867 PG 15 WC Optics SC Optics GA 089MK UT WOS:000314914500076 PM 23388813 ER PT J AU Gent, DB Wani, A Alshawabkeh, AN AF Gent, David B. Wani, Altaf Alshawabkeh, Akram N. TI Experimental design for one dimensional electrolytic reactive barrier for remediation of munition constituent in groundwater SO ELECTROCHIMICA ACTA LA English DT Article DE Alkaline hydrolysis; Electrolysis; Munition; Groundwater ID ALKALINE-HYDROLYSIS; ELECTROCHEMICAL REDUCTION; ACTIVATED CARBON; EXPLOSIVES RDX; 1,3,5-TRIAZA-1,3,5-TRINITROCYCLOHEXANE; WATER AB A combination of direct electrochemical reduction and in situ alkaline hydrolysis has been proposed to decompose energetic contaminants such as 1,3,5-trinitroperhydro-1,3,5-triazine and 2,4,6-trinitrotoluene (RDX) in deep aquifers. This process utilizes natural groundwater convection to carry hydroxide produced by an upstream cathode to remove the contaminant at the cathode as well as in the pore water downstream as it migrates toward the anode. Laboratory evaluation incorporated fundamental principles of column design coupled with reactive contaminant modeling including electrokinetics transport. Batch and horizontal sand-packed column experiments included both alkaline hydrolysis and electrochemical treatment to determine RDX decomposition reaction rate coefficients. The sand packed columns simulated flow through a contaminated aquifer with a seepage velocity of 30.5 cm/day. Techniques to monitor and record the transient electric potential, hydroxide transport and contaminant concentration within the column were developed. The average reaction rate coefficients for both the alkaline batch (0.0487 h(-1)) and sand column (0.0466 h(-1)) experiments estimated the distance between the cathode and anode required to decompose 0.5 mg/L RDX to the USEPA drinking water lifetime Health Advisory level of 0.002 mg/L to be 145 and 152 cm. (C) 2012 Elsevier Ltd. All rights reserved. C1 [Gent, David B.] USACE ERDC EL, Vicksburg, MS USA. [Wani, Altaf] Refineria Cartagena Reficar, Houston, TX USA. [Alshawabkeh, Akram N.] Northeastern Univ, Boston, MA 02115 USA. RP Alshawabkeh, AN (reprint author), Northeastern Univ, 360 Huntington Ave, Boston, MA 02115 USA. EM aalsha@coe.neu.edu FU US Army Environmental Quality Technology Research and Development Program; National Institute of Environmental Health Sciences (NIEHS) [P42ES017198] FX The authors gratefully acknowledge the financial support provided by US Army Environmental Quality Technology Research and Development Program. The third author was also partially supported for this work by Award P42ES017198 from the National Institute of Environmental Health Sciences (NIEHS). The content is solely the responsibility of the authors and does not necessarily represent the official views of the US Army Corps of Engineer or the NIEHS. The use of trade and product names is for descriptive purposes only and does not constitute endorsement by the US Government. NR 19 TC 1 Z9 1 U1 1 U2 21 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0013-4686 J9 ELECTROCHIM ACTA JI Electrochim. Acta PD DEC 30 PY 2012 VL 86 SI SI BP 130 EP 137 DI 10.1016/j.electacta.2012.04.043 PG 8 WC Electrochemistry SC Electrochemistry GA 067SO UT WOS:000313315600019 PM 23472044 ER PT J AU Wu, XZ Gent, DB Davis, JL Alshawabkeh, AN AF Wu, Xingzhi Gent, David B. Davis, Jeffrey L. Alshawabkeh, Akram N. TI Lactate injection by electric currents for bioremediation of tetrachloroethylene in clay SO ELECTROCHIMICA ACTA LA English DT Article DE Reductive dechlorination; Bioremediation; Electrokinetics; Tetrachloroethylene (PCE); Lactate ID DC FIELDS; BIOAUGMENTATION; DECHLORINATION; MIGRATION; TRANSPORT; ETHENE; SOIL AB Biological transformation of tetrachloroethylene (PCE) in silty clay samples by ionic injection of lactate under electric fields is evaluated. To prepare contaminated samples, a silty clay slurry was mixed with PCE, inoculated with KB-1 (R) dechlorinators and was consolidated in a 40 cm long cell. A current density between 5.3 and 13.3 A m(-2) was applied across treated soil samples while circulating electrolytes containing 10 mg L-1 lactate concentration between the anode and cathode compartments to maintain neutral pH and chemically reducing boundary conditions. The total adsorbed and aqueous PCE was degraded in the soil to trichloroethylene (TCE), cis-1,2-dichloroethene (cis-DCE), vinyl chloride (VC) and ethene in 120d, which is about double the time expected for transformation. Lactate was delivered into the soil by a reactive transport rate of 3.7 cm(2) d(-1) V-1. PCE degradation in the clay samples followed zero order transformation rates ranging from 1.5 to 5 mg L-1 d(-1) without any significant formation of TCE. cis-DCE transformation followed first order transformation rates of 0.06-0.10 per day. A control experiment conducted with KB-1 and lactate, but without electricity did not show any significant lactate buildup or cis-DCE transformation because the soil was practically impermeable (hydraulic conductivity of 2 x 10(-7) cm s(-1)). It is concluded that ionic migration will deliver organic additives and induce biological activity and complete PCE transformation in clay, even though the transformation occurs under slower rates compared to ideal conditions. (C) 2012 Elsevier Ltd. All rights reserved. C1 [Alshawabkeh, Akram N.] Northeastern Univ, Dept Civil & Environm Engn, Boston, MA 02115 USA. [Gent, David B.; Davis, Jeffrey L.] USA, Environm Lab, Engineer Res & Dev Ctr, Vicksburg, MS USA. RP Alshawabkeh, AN (reprint author), Northeastern Univ, Dept Civil & Environm Engn, 360 Huntington Ave, Boston, MA 02115 USA. EM aalsha@coe.neu.edu FU Environmental Laboratory of the U.S. Army Engineer Research and Development Center (ERDC-EL) through the US Army's Research Development Technology and Evaluation (RDTE) program; National Institute of Environmental Health Sciences (NIEHS) [P42ES017198] FX The authors gratefully acknowledge the support provided by Environmental Laboratory of the U.S. Army Engineer Research and Development Center (ERDC-EL) through the US Army's Research Development Technology and Evaluation (RDTE) program. This work was also partially supported by Award Number P42ES017198 from the National Institute of Environmental Health Sciences (NIEHS). The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIEHS or the US Army Corps of Engineers. NR 20 TC 5 Z9 5 U1 0 U2 21 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0013-4686 J9 ELECTROCHIM ACTA JI Electrochim. Acta PD DEC 30 PY 2012 VL 86 SI SI BP 157 EP 163 DI 10.1016/j.electacta.2012.06.046 PG 7 WC Electrochemistry SC Electrochemistry GA 067SO UT WOS:000313315600023 PM 23264697 ER PT J AU Cresce, AV Borodin, O Xu, K AF Cresce, Arthur von Wald Borodin, Oleg Xu, Kang TI Correlating Li+ Solvation Sheath Structure with Interphasial Chemistry on Graphite SO JOURNAL OF PHYSICAL CHEMISTRY C LA English DT Article ID PROPYLENE CARBONATE; GRAPHITE/ELECTROLYTE INTERFACE; NONAQUEOUS ELECTROLYTES; ETHYLENE CARBONATE; LITHIUM; MIXTURES; ANODE; ION; REDUCTION; BATTERIES AB In electrolytes with unique electrochemical signature, the structure of Li+ solvation sheath was quantitatively analyzed in correlation with its electrochemical behavior on graphitic anodes. For the first time, a direct link between Li+ solvation sheath structure and formation chemistry of the solid electrolyte interphase (SEI) is established. Quantum chemistry calculations and molecular dynamics simulations were performed to explain the observed reversed preference of propylene carbonate (PC) over ethylene carbonate (EC) by Li+. C1 [Cresce, Arthur von Wald; Borodin, Oleg; Xu, Kang] USA, Electrochem Branch, Power & Energy Div, Sensor & Elect Devices Directorate,Res Lab, Adelphi, MD 20783 USA. RP Xu, K (reprint author), USA, Electrochem Branch, Power & Energy Div, Sensor & Elect Devices Directorate,Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM conrad.k.xu.civ@mail.mil RI Cresce, Arthur/K-3958-2013; Borodin, Oleg/B-6855-2012 OI Cresce, Arthur/0000-0002-3894-6083; Borodin, Oleg/0000-0002-9428-5291 FU Advanced Battery Research for Transportation Program of Department of Energy (DOE-ABRT) [DE-IA01-11EE003413] FX This work was supported by Advanced Battery Research for Transportation Program of Department of Energy (DOE-ABRT) via an Interagency Agreement between the U.S. Department of Energy and the U.S. Army Research Laboratory DE-IA01-11EE003413. We also want to thank Dr. Yue Li of University of Maryland, College Park, who provided ESI-MS services, and Dr. Zhenhua Mao of ConocoPhilips, who provided complementary graphitic anode materials. NR 31 TC 27 Z9 27 U1 6 U2 93 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1932-7447 J9 J PHYS CHEM C JI J. Phys. Chem. C PD DEC 20 PY 2012 VL 116 IS 50 BP 26111 EP 26117 DI 10.1021/jp303610t PG 7 WC Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary SC Chemistry; Science & Technology - Other Topics; Materials Science GA 056VN UT WOS:000312519600001 ER PT J AU Samy, RP Rajendran, P Li, F Anandi, NM Stiles, BG Ignacimuthu, S Sethi, G Chow, VTK AF Samy, Ramar Perumal Rajendran, Peramaiyan Li, Feng Anandi, Narayana Moorthy Stiles, Bradley G. Ignacimuthu, Savarimuthu Sethi, Gautam Chow, Vincent T. K. TI Identification of a Novel Calotropis procera Protein That Can Suppress Tumor Growth in Breast Cancer through the Suppression of NF-kappa B Pathway SO PLOS ONE LA English DT Article ID BRCA1/2 MUTATION CARRIERS; S-TRANSFERASE EXPRESSION; CULEX-QUINQUEFASCIATUS; MAMMOGRAPHIC DENSITY; MAMMARY-TUMORS; PLANT-EXTRACTS; RATS; CELLS; RISK; APOPTOSIS AB Breast cancer is the most common cancer among women. To date, improvements in hormonal and cytotoxic therapies have not yet led to a sustained remission or cure. In the present study, we investigated the in vitro and in vivo antitumor activities of a novel Calotropis procera protein (CP-P) isolated from root bark. CP-P protein inhibited the proliferation and induced apoptosis of breast cancer cells through the suppression of nuclear factor kappaB (NF-kB) activation. CP-P, when administered individually or in combination with cyclophosphamide (CYC, 0.2 mg/kg) to rats with 7, 12-dimethyl benz(a) anthracene (DMBA)-induced breast cancer decreased tumor volume significantly without affecting the body weight. To elucidate the anticancer mechanism of CP-P, antioxidant activities such as superoxide dismutase (SOD), catalase (CAT), glutathione-s-transferase (GST) and non-enzymatic antioxidant - reduced glutathione (GSH), vitamin E and C generation in the breast were analyzed by various assays. SOD, CAT, GST, GSH, vitamin E and C levels were high in combination-treated groups (CP-P+CYC) versus the CYC alone-treated groups. Also, the combination was more effective in down-regulating the expression of NF-kB-regulated gene products (cyclin D1 and Bcl-2) in breast tumor tissues. Our findings indicate that CP-P possesses significant antitumor activity comparable to a commonly used anticancer drug, cyclophosphamide, and may form the basis of a novel therapy for breast cancer. C1 [Samy, Ramar Perumal; Anandi, Narayana Moorthy; Chow, Vincent T. K.] Natl Univ Singapore, Natl Univ Hlth Syst, Yong Loo Lin Sch Med, Dept Microbiol,Infect Dis Programme, Singapore 117548, Singapore. [Rajendran, Peramaiyan; Li, Feng; Sethi, Gautam] Natl Univ Singapore, Natl Univ Hlth Syst, Yong Loo Lin Sch Med, Dept Pharmacol,Clin Res Ctr, Singapore 117548, Singapore. [Ignacimuthu, Savarimuthu] Loyola Coll, Entomol Res Inst, Chennai, Tamil Nadu, India. [Stiles, Bradley G.] USA, Integrated Toxicol Div, Med Res Inst Infect Dis, Ft Detrick, MD USA. [Stiles, Bradley G.] Wilson Coll, Chambersburg, PA USA. RP Samy, RP (reprint author), Natl Univ Singapore, Natl Univ Hlth Syst, Yong Loo Lin Sch Med, Dept Microbiol,Infect Dis Programme, Singapore 117548, Singapore. EM rperumalsamy@yahoo.co.uk RI Sethi, Gautam/F-2372-2011; Rajendran, Peramaiyan/I-3877-2012 OI Rajendran, Peramaiyan/0000-0001-6354-4388 FU Council of Scientific and Industrial Research [2000-CSIR]; Extramural Research Division, Government of India, New Delhi; NUS Academic Research Fund (ARF) FX The authors acknowledge the Council of Scientific and Industrial Research (2000-CSIR), Extramural Research Division, Government of India, New Delhi for the award of Research Associate (RA) to first author and financial assistance to carry out this work. The work was also supported in part by the grants from NUS Academic Research Fund (ARF) to GS. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 75 TC 11 Z9 15 U1 3 U2 27 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD DEC 20 PY 2012 VL 7 IS 12 AR e48514 DI 10.1371/journal.pone.0048514 PG 14 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 060RA UT WOS:000312794500006 PM 23284617 ER PT J AU Keh, CE Jha, AR Nzarubara, B Lanar, DE Dutta, S Theisen, M Rosenthal, PJ Dorsey, G Nixon, DF Greenhouse, B AF Keh, Chris E. Jha, Aashish R. Nzarubara, Bridget Lanar, David E. Dutta, Sheetij Theisen, Michael Rosenthal, Philip J. Dorsey, Grant Nixon, Douglas F. Greenhouse, Bryan TI Associations between Antibodies to a Panel of Plasmodium falciparum Specific Antigens and Response to Sub-Optimal Antimalarial Therapy in Kampala, Uganda SO PLOS ONE LA English DT Article ID MEROZOITE SURFACE PROTEIN-1; GLUTAMATE-RICH PROTEIN; CLINICAL MALARIA; ESCHERICHIA-COLI; HOST IMMUNITY; CHILDREN; PROTECTION; TRANSMISSION; EFFICACY; IMMUNOGENICITY AB Background: Antibodies are important in the control of blood stage Plasmodium falciparum infection. It is unclear which antibody responses are responsible for, or even associated with protection, partly due to confounding by heterogeneous exposure. Assessment of response to partially effective antimalarial therapy, which requires the host to assist in clearing parasites, offers an opportunity to measure protection independent of exposure. Methods: A cohort of children aged 1-10 years in Kampala, Uganda were treated with amodiaquine+sulfadoxine-pyrimethamine for uncomplicated malaria. Serum samples from the time of malaria diagnosis and 14 days later were analyzed for total IgG to 8 P. falciparum antigens using a quantitative indirect ELISA. Associations between antibody levels and risk of treatment failure were estimated using Cox proportional hazard regression. Results: Higher levels of antibodies to apical membrane antigen 1 (AMA-1), but to none of the other 7 antigens were significantly associated with protection against treatment failure (HR 0.57 per 10-fold increase in antibody level, CI 0.41-0.79, p = 0.001). Protection increased consistently across the entire range of antibody levels. Conclusions: Measurement of antibody levels to AMA-1 at the time of malaria may offer a quantitative biomarker of blood stage immunity to P. falciparum, a tool which is currently lacking. C1 [Keh, Chris E.; Jha, Aashish R.; Rosenthal, Philip J.; Dorsey, Grant; Nixon, Douglas F.; Greenhouse, Bryan] Univ Calif San Francisco, Dept Med, San Francisco, CA 94143 USA. [Nzarubara, Bridget] Infect Dis Res Collaborat, Kampala, Uganda. [Lanar, David E.; Dutta, Sheetij] Walter Reed Army Inst Res, Div Malaria Vaccine Dev, Silver Spring, MD USA. [Theisen, Michael] Statens Serum Inst, Dept Clin Biochem & Immunol, DK-2300 Copenhagen, Denmark. RP Greenhouse, B (reprint author), Univ Calif San Francisco, Dept Med, San Francisco, CA 94143 USA. EM bgreenhouse@medsfgh.ucsf.edu OI Nixon, Douglas/0000-0002-2801-1786; Greenhouse, Bryan/0000-0003-0287-9111 FU National Institutes of Health (NIH), National Institute of Allergy and Infectious Diseases (NIAID) [AI060530, AI076614]; International Centers of Excellence in Malaria Research [AI089674] FX This work was supported, in part, by the National Institutes of Health (NIH), National Institute of Allergy and Infectious Diseases (NIAID): T32 Training in HIV Translational Research [PI: Diane Havlir, grant number AI060530 to CEK]; K23 [PI: Bryan Greenhouse, grant number AI076614 to BG]; and International Centers of Excellence in Malaria Research U19 [PI: Grant Dorsey, grant number AI089674 to GD, BG]. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 41 TC 3 Z9 3 U1 0 U2 3 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD DEC 19 PY 2012 VL 7 IS 12 AR e52571 DI 10.1371/journal.pone.0052571 PG 8 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 059HF UT WOS:000312694300092 PM 23285095 ER PT J AU Srikiatkhachorn, A Wichit, S Gibbons, RV Green, S Libraty, DH Endy, TP Ennis, FA Kalayanarooj, S Rothman, AL AF Srikiatkhachorn, Anon Wichit, Sineewanlaya Gibbons, Robert V. Green, Sharone Libraty, Daniel H. Endy, Timothy P. Ennis, Francis A. Kalayanarooj, Siripen Rothman, Alan L. TI Dengue Viral RNA Levels in Peripheral Blood Mononuclear Cells Are Associated with Disease Severity and Preexisting Dengue Immune Status SO PLOS ONE LA English DT Article ID VIRUS-INFECTION; CYTOKINE PRODUCTION; ANTIBODY; REPLICATION; ENHANCEMENT; LYMPHOCYTES; ACTIVATION; LEUKOCYTES; ILLNESS; HUMANS AB Background: Infection with dengue viruses (DENV) causes a wide range of manifestations from asymptomatic infection to a febrile illness called dengue fever (DF), to dengue hemorrhagic fever (DHF). The in vivo targets of DENV and the relation between the viral burden in these cells and disease severity are not known. Method: The levels of positive and negative strand viral RNA in peripheral blood monocytes, T/NK cells, and B cells and in plasma of DF and DHF cases were measured by quantitative RT-PCR. Results: Positive strand viral RNA was detected in monocytes, T/NK cells and B cells with the highest amounts found in B cells. Viral RNA levels in CD14+ cells and plasma were significantly higher in DHF compared to DF, and in cases with a secondary infection compared to those undergoing a primary infection. The distribution of viral RNA among cell subpopulations was similar in DF and DHF cases. Small amounts of negative strand RNA were found in a few cases only. The severity of plasma leakage correlated with viral RNA levels in plasma and in CD14+ cells. Conclusions: B cells were the principal cells containing DENV RNA in peripheral blood, but overall there was little active DENV RNA replication detectable in peripheral blood mononuclear cells (PBMC). Secondary infection and DHF were associated with higher viral burden in PBMC populations, especially CD14+ monocytes, suggesting that viral infection of these cells may be involved in disease pathogenesis. C1 [Srikiatkhachorn, Anon; Green, Sharone; Libraty, Daniel H.; Ennis, Francis A.] Univ Massachusetts, Sch Med, Dept Med, Worcester, MA 01605 USA. [Wichit, Sineewanlaya; Gibbons, Robert V.] Armed Forces Res Inst Med Sci, Dept Virol, Bangkok 10400, Thailand. [Endy, Timothy P.] SUNY Syracuse, Dept Med, Upstate Med Univ, Syracuse, NY USA. [Kalayanarooj, Siripen] Queen Sirikit Natl Inst Child Hlth, Bangkok, Thailand. [Rothman, Alan L.] Univ Rhode Isl, Inst Immunol & Informat, Providence, RI 02908 USA. RP Srikiatkhachorn, A (reprint author), Univ Massachusetts, Sch Med, Dept Med, Worcester, MA 01605 USA. EM anon.srikiatkhachorn@umassmed.edu FU National Institutes of Health [NIH-P01AI34533]; Military Infectious Disease Research Program FX This work was supported by National Institutes of Health Grant [NIH-P01AI34533] and the Military Infectious Disease Research Program. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 25 TC 11 Z9 12 U1 0 U2 8 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD DEC 19 PY 2012 VL 7 IS 12 AR e51335 DI 10.1371/journal.pone.0051335 PG 6 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 059HF UT WOS:000312694300018 PM 23284680 ER PT J AU Peela, NR Lee, IC Vlachos, DG AF Peela, Nageswara Rao Lee, Ivan C. Vlachos, Dionisios G. TI Design and Fabrication of a High-Throughput Microreactor and Its Evaluation for Highly Exothermic Reactions SO INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH LA English DT Article ID COMBINATORIAL CATALYST LIBRARIES; ARTIFICIAL NEURAL-NETWORKS; HETEROGENEOUS CATALYSIS; PROPANE COMBUSTION; PARALLEL ANALYSIS; FLOW DISTRIBUTION; PLATINUM CATALYST; SUPPORT MATERIALS; OXIDATION-STATE; REACTOR AB The effect of distributor and channel positions on flow uniformity in a high-throughput reactor is studied using a COMSOL MULTIPHYSICS, CFD package. The best design is subsequently fabricated and evaluated for propane total oxidation reaction at low conversions. Comparison of our design with a literature design is also presented. The results indicate that the conical distributor performs significantly better in terms of flow uniformity as compared to the commonly used disc shaped distributor. The flow uniformity is improved when the central channel is removed from the design, indicating that the channel arrangement also affects the flow uniformity. The experimental results on flow uniformity are in good agreement with simulation. The deviation in conversion of propane from channel to channel is within experimental error, indicating that the reactor can reliably screen catalysts and deliver kinetics. A half a dozen catalysts were tested for complete propane oxidation using the developed technology. C1 [Peela, Nageswara Rao; Vlachos, Dionisios G.] Univ Delaware, Ctr Catalyt Sci & Technol, Dept Chem & Biomol Engn, Newark, DE 19716 USA. [Peela, Nageswara Rao; Vlachos, Dionisios G.] Univ Delaware, Catalysis Ctr Energy Innovat, Newark, DE 19716 USA. [Lee, Ivan C.] USA, Sensors & Electron Devices Directorate, Res Lab, Adelphi, MD 20783 USA. RP Vlachos, DG (reprint author), Univ Delaware, Ctr Catalyt Sci & Technol, Dept Chem & Biomol Engn, 150 Acad St, Newark, DE 19716 USA. EM vlachos@udel.edu RI Peela, Nageswara/L-4895-2013; OI Vlachos, Dionisios/0000-0002-6795-8403 FU Army Research Laboratory; [W911NF-10-2-0047] FX Research was sponsored by the Army Research Laboratory and was accomplished under Cooperative Agreement Number W911NF-10-2-0047. NR 41 TC 1 Z9 1 U1 4 U2 62 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0888-5885 J9 IND ENG CHEM RES JI Ind. Eng. Chem. Res. PD DEC 19 PY 2012 VL 51 IS 50 BP 16270 EP 16277 DI 10.1021/ie302093u PG 8 WC Engineering, Chemical SC Engineering GA 055RO UT WOS:000312434600012 ER PT J AU Taylor, DE McCauley, JW Wright, TW AF Taylor, DeCarlos E. McCauley, James W. Wright, T. W. TI The effects of stoichiometry on the mechanical properties of icosahedral boron carbide under loading SO JOURNAL OF PHYSICS-CONDENSED MATTER LA English DT Article ID MOLECULAR-DYNAMICS; CRYSTAL-STRUCTURE; ALPHA-QUARTZ; INSTABILITIES; PRESSURE; CARBON; POWDER AB The effects of stoichiometry on the atomic structure and the related mechanical properties of boron carbide (B4C) have been studied using density functional theory and quantum molecular dynamics simulations. Computational cells of boron carbide containing up to 960 atoms and spanning compositions ranging from 6.7% to 26.7% carbon were used to determine the effects of stoichiometry on the atomic structure, elastic properties, and stress-strain response as a function of hydrostatic, uniaxial, and shear loading paths. It was found that different stoichiometries, as well as variable atomic arrangements within a fixed stoichiometry, can have a significant impact on the yield stress of boron carbide when compressed uniaxially (by as much as 70% in some cases); the significantly reduced strength of boron carbide under shear loading is also demonstrated. C1 [Taylor, DeCarlos E.; McCauley, James W.] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. [Wright, T. W.] Johns Hopkins Univ, Dept Mech Engn, Baltimore, MD 21218 USA. RP Taylor, DE (reprint author), USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. EM decarlos.e.taylor.civ@mail.mil; james.w.mccauley.civ@mail.mil FU Army Research Laboratory; Department of Defense High Performance Computing and Modernization Program [ARLAPC5L] FX Financial support of this work was granted as a part of the Director's Research Initiative program at the Army Research Laboratory. All calculations were conducted using computational resources maintained by the Department of Defense High Performance Computing and Modernization Program (Challenge Project No. ARLAPC5L). The authors would also like thank Dr K T Ramesh of the Johns Hopkins University (Baltimore, MD) for many useful discussions. NR 44 TC 13 Z9 13 U1 1 U2 32 PU IOP PUBLISHING LTD PI BRISTOL PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND SN 0953-8984 J9 J PHYS-CONDENS MAT JI J. Phys.-Condes. Matter PD DEC 19 PY 2012 VL 24 IS 50 AR 505402 DI 10.1088/0953-8984/24/50/505402 PG 11 WC Physics, Condensed Matter SC Physics GA 048DT UT WOS:000311891100010 PM 23165091 ER PT J AU Starzengruber, P Swoboda, P Fuehrer, HP Khan, WA Hofecker, V Siedl, A Fally, M Graf, O Teja-Isavadharm, P Haque, R Ringwald, P Noedl, H AF Starzengruber, Peter Swoboda, Paul Fuehrer, Hans-Peter Khan, Wasif A. Hofecker, Verena Siedl, Anja Fally, Markus Graf, Oliver Teja-Isavadharm, Paktiya Haque, Rashidul Ringwald, Pascal Noedl, Harald TI Current Status of Artemisinin-Resistant falciparum Malaria in South Asia: A Randomized Controlled Artesunate Monotherapy Trial in Bangladesh SO PLOS ONE LA English DT Article ID THERAPEUTIC-EFFICACY; CLINICAL-TRIAL; PLASMODIUM; SPREAD; CAMBODIA; ASSAY AB Objective: Recent reports indicate that first cases of genuine artemisinin resistance have already emerged along the Thai-Cambodian border. The main objective of this trial was to track the potential emergence of artemisinin resistance in Bangladesh, which in terms of drug resistance forms a gateway to the Indian subcontinent. Methods: We conducted an open-label, randomized, controlled 42-day clinical trial in Southeastern Bangladesh to investigate the potential spread of clinical artemisinin resistance from Southeast Asia. A total of 126 uncomplicated falciparum malaria patients were randomized to one of 3 treatment arms (artesunate monotherapy with 2 or 4 mg/kg/day once daily or quinine plus doxycycline TID for 7 days). Only cases fulfilling a stringent set of criteria were considered as being artemisinin-resistant. Findings: The 28-day and 42-day cure rates in the artesunate monotherapy (2 and 4 mg/kg) and quinine/doxycyline arms were 97.8% (95% confidence interval, CI: 87.8-99.8%), 100% (95% CI: 91.1-100%), and 100% (95% CI: 83.4-100%), respectively. One case of re-infection was seen in the artesunate high dose arm, and a single case of recrudescence was observed in the low dose group on day 26. No differences in median parasite and fever clearance times were found between the 2 artesunate arms (29.8 h and 17.9 h vs. 29.5 h and 19.1 h). Not a single case fulfilled our criteria of artemisinin resistance. Parasite clearance times were considerably shorter and ex vivo results indicate significantly higher susceptibility (50% inhibitory concentration for dihydroartemisinin was 1.10 nM; 95% CI: 0.95-1.28 nM) to artemisinins as compared to SE-Asia. Conclusion: There is currently no indication that artemisinin resistance has reached Bangladesh. However, the fact that resistance has recently been reported from nearby Myanmar indicates an urgent need for close monitoring of artemisinin resistance in the region. C1 [Starzengruber, Peter; Swoboda, Paul; Fuehrer, Hans-Peter; Hofecker, Verena; Siedl, Anja; Fally, Markus; Graf, Oliver; Noedl, Harald] Med Univ Vienna, Inst Specif Prophylaxis & Trop Med, Vienna, Austria. [Starzengruber, Peter; Swoboda, Paul; Fuehrer, Hans-Peter; Hofecker, Verena; Siedl, Anja; Fally, Markus; Graf, Oliver; Noedl, Harald] Malaria Res Initiat Bandarban, MARIB, Bandarban, Bangladesh. [Khan, Wasif A.; Haque, Rashidul] Int Ctr Diarrhoeal Dis Res, Dhaka 1000, Bangladesh. [Teja-Isavadharm, Paktiya] US Army Med Component Armed Forces Res Inst Med S, Dept Immunol & Med, Bangkok, Thailand. [Ringwald, Pascal] WHO, Global Malaria Programme, CH-1211 Geneva, Switzerland. RP Noedl, H (reprint author), Med Univ Vienna, Inst Specif Prophylaxis & Trop Med, Vienna, Austria. EM harald.noedl@meduniwien.ac.at FU Bill & Melinda Gates Foundation FX This trial was funded by the Bill & Melinda Gates Foundation. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 23 TC 15 Z9 15 U1 0 U2 16 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD DEC 18 PY 2012 VL 7 IS 12 AR e52236 DI 10.1371/journal.pone.0052236 PG 7 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 056JC UT WOS:000312483300070 PM 23272227 ER PT J AU Furtado, AMB Barpaga, D Mitchell, LA Wang, Y DeCoste, JB Peterson, GW LeVan, MD AF Furtado, Amanda M. B. Barpaga, Dushyant Mitchell, Lucas A. Wang, Yu DeCoste, Jared B. Peterson, Gregory W. LeVan, M. Douglas TI Organoalkoxysilane-Grafted Silica Composites for Acidic and Basic Gas Adsorption SO LANGMUIR LA English DT Article ID REVERSIBLE POLYMERIC SORBENTS; MESOPOROUS SILICA; ENGINEERING NANOSPACES; CONTROLLABLE CHEMISTRY; ZIRCONIUM HYDROXIDE; FUNCTIONAL-GROUPS; CO-CONDENSATION; OXIDE SURFACES; AMMONIA; SBA-15 AB With the prevalence of air quality issues in our society, the ability to remove toxic gases from air is a necessity. This work addresses the development of biphasic, nanostructured, organoalkoxysilane-grafted, siliceous materials for use in single pass filters of various types for the removal of acidic and basic gases from humid air. Materials exhibit high single pass capacities for sulfur dioxide, a representative acid-forming gas, or ammonia, a representative basic gas. The nanostructured siliceous support provides initial ammonia capacity, and grafted amine and carbonyl groups provide desired functional chemistries for sulfur dioxide and enhanced ammonia capacities. Methacryloxypropyltrimethoxysilane (MAPS)-MCM-41 has the highest ammonia capacity at about 7 mol/kg at 1500 ppmv and 23 degrees C, and 3-aminopropyltriethoxysilane (APTES)-MCM-41 has the highest sulfur dioxide capacity at 0.85 mol/kg at 500 ppmv and 23 degrees C. These biphasic materials exhibit high adsorption capacity for two distinct gases and are promising candidates as adsorbents for protection from toxic industrial gases. C1 [Furtado, Amanda M. B.; Barpaga, Dushyant; Mitchell, Lucas A.; Wang, Yu; LeVan, M. Douglas] Vanderbilt Univ, Dept Chem & Biomol Engn, Nashville, TN 37235 USA. [DeCoste, Jared B.; Peterson, Gregory W.] USA, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. RP LeVan, MD (reprint author), Vanderbilt Univ, Dept Chem & Biomol Engn, Nashville, TN 37235 USA. EM m.douglas.levan@vanderbilt.edu RI DeCoste, Jared/B-5519-2013 FU U.S. Army Edgewood Chemical Biological Center; Defense Threat Reduction Agency [W911SR-08-C-0028]; U.S. Army Research Office under DURIP Award [W911NF-11-1-0370] FX We are grateful to the U.S. Army Edgewood Chemical Biological Center and the Defense Threat Reduction Agency for the support of this research under Contract W911SR-08-C-0028 and to the U.S. Army Research Office for providing DRIFTS instrumentation under DURIP Award W911NF-11-1-0370. NR 53 TC 12 Z9 14 U1 2 U2 57 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0743-7463 J9 LANGMUIR JI Langmuir PD DEC 18 PY 2012 VL 28 IS 50 BP 17450 EP 17456 DI 10.1021/la303203k PG 7 WC Chemistry, Multidisciplinary; Chemistry, Physical; Materials Science, Multidisciplinary SC Chemistry; Materials Science GA 055RK UT WOS:000312434200028 PM 23186068 ER PT J AU Moe, CG Garrett, GA Rotella, P Shen, HE Wraback, M Shatalov, M Sun, WH Deng, JY Hu, XH Bilenko, Y Yang, JW Gaska, R AF Moe, Craig G. Garrett, Gregory A. Rotella, Paul Shen, Hongen Wraback, Michael Shatalov, Max Sun, Wenhong Deng, Jianyu Hu, Xuhong Bilenko, Yuri Yang, Jinwei Gaska, Remis TI Impact of temperature-dependent hole injection on low-temperature electroluminescence collapse in ultraviolet light-emitting diodes SO APPLIED PHYSICS LETTERS LA English DT Article ID 285 NM; EFFICIENCY AB Optical and electronic properties of mid-ultraviolet light emitting diodes with a two-step p-AlGaN region are measured at temperatures from 8 to 300 K. While the electroluminescence intensity increases down to a temperature lower than that reported in InGaN light emitting diodes (LEDs), there is still a collapse at cryogenic temperatures. Capacitance-voltage measurements across the same range of temperatures reveal an increasing depletion region with decreasing temperature indicating that hole injection is a significant factor in the temperature dependent behavior, as well as the cause of electroluminescence collapse. (C) 2012 American Institute of Physics. [http://dx.doi.org/10.1063/1.4772506] C1 [Moe, Craig G.; Garrett, Gregory A.; Rotella, Paul; Shen, Hongen; Wraback, Michael] USA, Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA. [Shatalov, Max; Sun, Wenhong; Deng, Jianyu; Hu, Xuhong; Bilenko, Yuri; Yang, Jinwei; Gaska, Remis] Sensor Elect Technol Inc, Columbia, SC 29209 USA. RP Moe, CG (reprint author), USA, Res Lab, Sensors & Electron Devices Directorate, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM michael.wraback.civ@mail.mil NR 14 TC 4 Z9 4 U1 1 U2 38 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD DEC 17 PY 2012 VL 101 IS 25 AR 253512 DI 10.1063/1.4772506 PG 4 WC Physics, Applied SC Physics GA 060LR UT WOS:000312780000104 ER PT J AU Svensson, SP Sarney, WL Hier, H Lin, Y Wang, D Donetsky, D Shterengas, L Kipshidze, G Belenky, G AF Svensson, S. P. Sarney, W. L. Hier, H. Lin, Y. Wang, D. Donetsky, D. Shterengas, L. Kipshidze, G. Belenky, G. TI Band gap of InAs1-xSbx with native lattice constant SO PHYSICAL REVIEW B LA English DT Article ID STRAINED-LAYER SUPERLATTICES; MOLECULAR-BEAM EPITAXY; ALLOYS; PHOTOLUMINESCENCE; SEMICONDUCTORS; REDUCTION; PROPOSAL; INAS; GAAS AB The band gap energy of the alloy InAsSb has been studied as a function of composition with special emphasis on minimization of strain-induced artifacts. The films were grown by molecular beam epitaxy on GaSb substrates with compositionally graded buffer layers that were designed to produce strain-free films. The compositions were precisely determined by high-resolution x-ray diffraction. Evidence for weak, long-range, group-V ordering was detected in materials exhibiting residual strain and relaxation. In contrast, unstrained films having the nondistorted cubic form showed no evidence of group-V ordering. The photoluminescence (PL) peak positions therefore corresponds to the inherent band gap of unstrained, unrelaxed, InAsSb. PL peaks were recorded for compositions up to 46% Sb, reaching a peak wavelength of 10.3 mu m, observed under low excitation at T = 13 K. The alloy band gap energies determined from PL maxima are described with a bowing parameter of 0.87 eV, which is significantly larger than measured for InAsSb in earlier work. The sufficiently large bowing parameter and the ability to grow the alloys without ordering allows direct band gap InAsSb to be a candidate material for low-temperature long-wavelength infrared detector applications. DOI: 10.1103/PhysRevB.86.245205 C1 [Svensson, S. P.; Sarney, W. L.; Hier, H.] USA, Res Lab, Adelphi, MD 20783 USA. [Lin, Y.; Wang, D.; Donetsky, D.; Shterengas, L.; Kipshidze, G.; Belenky, G.] SUNY Stony Brook, Dept Elect & Comp Engn, Stony Brook, NY 11794 USA. RP Svensson, SP (reprint author), USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. OI LIN, YOUXI/0000-0002-9092-2302 FU NSF [DMR1160843]; ARO [W911NF11-1-0109] FX Part of this work was funded by NSF Grant DMR1160843 and ARO Grant W911NF11-1-0109. NR 35 TC 22 Z9 22 U1 3 U2 48 PU AMER PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 1098-0121 J9 PHYS REV B JI Phys. Rev. B PD DEC 17 PY 2012 VL 86 IS 24 AR 245205 DI 10.1103/PhysRevB.86.245205 PG 6 WC Physics, Condensed Matter SC Physics GA 054TG UT WOS:000312365800007 ER PT J AU Wong, KK Bulimo, WD Magana, J Achilla, RA Schwarcz, SK Simwa, M Majanja, JM Wadegu, MO Osuna, FA Mukunzi, SO Mwangi, JK Wangui, JM Muthoni, JN Njiri, JO Obura, BD Opot, BH Mitei, KK Barani, J Lifumo, S Schnabel, DC AF Wong, Karen K. Bulimo, Wallace D. Magana, Japhet Achilla, Rachel A. Schwarcz, Sandra K. Simwa, Maylor Majanja, Janet M. Wadegu, Meshack O. Osuna, Finley A. Mukunzi, Silvanos O. Mwangi, Josephat K. Wangui, Julia M. Muthoni, Janet N. Njiri, James O. Obura, Beryl D. Opot, Benjamin H. Mitei, Keneth K. Barani, Jane Lifumo, Samwel Schnabel, David C. TI Epidemiology of 2009 Pandemic Influenza A Virus Subtype H1N1 Among Kenyans Aged 2 Months to 18 Years, 2009-2010 SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article ID NEW-YORK-CITY; SCHOOL CLOSURE; TRANSMISSION; SURVEILLANCE; CHILDREN AB Background. The US Army Medical Research Unit-Kenya (USAMRU-K) conducts surveillance for influenza-like illness (ILI) in Kenya. We describe the temporal and geographic progression of A(H1N1)pdm09 as it emerged in Kenya and characterize the outpatient population with A(H1N1)pdm09 infection. Methods. We included patients with ILI aged 2 months to 18 years enrolled during June 2009-August 2010. Respiratory specimens were tested by real-time reverse-transcription polymerase chain reaction for influenza virus. Patients with A(H1N1)pdm09 infection were compared to those with seasonal influenza A virus infection and those with ILI who had no virus or a virus other than influenza virus identified (hereafter, "noninfluenza ILI"). Results. Of 4251 patients with ILI, 193 had laboratory-confirmed A(H1N1)pdm09 infection. The first pandemic influenza case detected by USAMRU-K surveillance was in August 2009; peak activity nationwide occurred during October-November 2009. Patients with A(H1N1)pdm09 infection were more likely to be school-aged, compared with patients with seasonal influenza A virus infection (prevalence ratio [PR], 2.0; 95% confidence interval [CI], 1.3-3.1) or noninfluenza ILI (PR, 3.2; 95% CI, 2.4-4.3). Conclusions. USAMRU-K ILI surveillance detected the geographic and temporal distribution of pandemic influenza in Kenya. The age distribution of A(H1N1)pdm09 infections included more school-aged children, compared with seasonal influenza A virus infection and noninfluenza ILI. C1 [Schwarcz, Sandra K.] Univ Calif San Francisco, Dept Epidemiol & Biostat, Div Prevent Med & Publ Hlth, San Francisco, CA 94143 USA. [Wong, Karen K.] Univ Calif San Francisco, Dept Med, San Francisco, CA 94143 USA. [Schwarcz, Sandra K.] San Francisco Dept Publ Hlth, San Francisco, CA USA. [Bulimo, Wallace D.; Achilla, Rachel A.; Majanja, Janet M.; Wadegu, Meshack O.; Osuna, Finley A.; Mukunzi, Silvanos O.; Mwangi, Josephat K.; Wangui, Julia M.; Muthoni, Janet N.; Njiri, James O.; Obura, Beryl D.; Opot, Benjamin H.; Mitei, Keneth K.; Schnabel, David C.] US Army Med Res Unit Kenya, Nairobi, Kenya. [Magana, Japhet; Simwa, Maylor; Osuna, Finley A.; Barani, Jane; Lifumo, Samwel] Kenya Govt Med Res Ctr, Nairobi, Kenya. RP Schnabel, DC (reprint author), Walter Reed Army Inst Res, Prevent Med Program, 503 Robert Grant Rd, Silver Spring, MD 20910 USA. EM david.c.schnabel@us.army.mil RI Bulimo, Wallace/B-1982-2014 OI Bulimo, Wallace/0000-0001-8475-0586 FU Department of Defense Armed Forces Health Surveillance Center FX This work was supported by the Department of Defense Armed Forces Health Surveillance Center. NR 23 TC 1 Z9 1 U1 0 U2 3 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD DEC 15 PY 2012 VL 206 SU 1 BP S68 EP S73 DI 10.1093/infdis/jis585 PG 6 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 045BA UT WOS:000311667900011 PM 23169975 ER PT J AU Malinovsky, VS Rudin, S AF Malinovsky, Vladimir S. Rudin, Sergey TI Geometric single-qubit gates for an electron spin in a quantum dot SO INTERNATIONAL JOURNAL OF QUANTUM CHEMISTRY LA English DT Article DE geometric phase; electron-spin qubit; quantum dot; quantum gate ID COMPUTATION; PULSES AB Using the analytic expression of the evolution operator for the electron spin in a quantum dot, we propose a scheme to design a universal set of single-qubit gates based solely on the geometric phase that the qubit state acquires after a cyclic evolution in the parameter space. The scheme is using ultrafast linearly chirped pulses providing adiabatic excitation of the qubit states and the geometric phase is fully controlled by the relative phase between pulses. (C) 2012 Wiley Periodicals, Inc. C1 [Malinovsky, Vladimir S.; Rudin, Sergey] USA, Res Lab, Adelphi, MD 20783 USA. RP Malinovsky, VS (reprint author), USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM vsmalinovsky@gmail.com NR 23 TC 0 Z9 0 U1 0 U2 9 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0020-7608 J9 INT J QUANTUM CHEM JI Int. J. Quantum Chem. PD DEC 15 PY 2012 VL 112 IS 24 SI SI BP 3744 EP 3749 DI 10.1002/qua.24202 PG 6 WC Chemistry, Physical; Mathematics, Interdisciplinary Applications; Physics, Atomic, Molecular & Chemical SC Chemistry; Mathematics; Physics GA 035VD UT WOS:000310977900004 ER PT J AU Luo, YT Guo, JC Liu, YH Shao, Q Wang, CS Chu, DY AF Luo, Yanting Guo, Juchen Liu, Yihang Shao, Qian Wang, Chunsheng Chu, Deryn TI Copolymerization of methyl methacrylate and vinylbenzyl chloride towards alkaline anion exchange membrane for fuel cell applications SO JOURNAL OF MEMBRANE SCIENCE LA English DT Article DE Alkaline fuel cells; Alkaline anion exchange membranes; Emulsion polymerization; Crosslinking ID ELECTROLYTE; CHITOSAN; ACRYLATE AB Our previous studies demonstrated great potential of methyl methacrylate and vinylbenzyl chloride based copolymer electrolytes for alkaline fuel cell applications. In this study, a number of factors including polymer composition drift, molecular weight, and polymer crosslinking is investigated to understand their effects and to precisely control the electrolyte properties including conductivity, mechanical strength, and water mass-uptake. This investigation demonstrated a controllable polymerization procedure of poly (methyl methacrylate-co-vinylbenzyl chloride) membrane with tunable and balanced properties, which is promising for the alkaline fuel cell technology. (C) 2012 Elsevier B.V. All rights reserved. C1 [Guo, Juchen] Univ Calif Riverside, Dept Chem & Environm Engn, Riverside, CA 92521 USA. [Shao, Qian] Univ Maryland, Dept Chem, College Pk, MD 20742 USA. [Chu, Deryn] USA, Res Lab, Sensors & Electron Device Directorate, Adelphi, MD 20783 USA. [Luo, Yanting; Liu, Yihang; Wang, Chunsheng] Univ Maryland, Dept Chem & Biomol Engn, College Pk, MD 20742 USA. RP Guo, JC (reprint author), Univ Calif Riverside, Dept Chem & Environm Engn, Riverside, CA 92521 USA. EM jguo@engr.ucr.edu RI Wang, Chunsheng/H-5767-2011; Liu, Yihang/E-6958-2013 OI Wang, Chunsheng/0000-0002-8626-6381; Liu, Yihang/0000-0002-2491-9439 FU Army Research Lab [W911NF0920007]; Army Research Office [W911NF0910028] FX This research was supported by Army Research Lab (W911NF0920007) and Army Research Office (W911NF0910028). The authors were grateful to Prof. P. Kofinas and Prof. S.R. Raghavan at the University of Maryland for the technical support of polymer characterization. NR 26 TC 6 Z9 6 U1 2 U2 54 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0376-7388 J9 J MEMBRANE SCI JI J. Membr. Sci. PD DEC 15 PY 2012 VL 423 BP 209 EP 214 DI 10.1016/j.memsci.2012.08.016 PG 6 WC Engineering, Chemical; Polymer Science SC Engineering; Polymer Science GA 042OP UT WOS:000311480800023 ER PT J AU Hale, DF Vreeland, TJ Perez, SA Berry, JS Ardavanis, A Trappey, AF Tzonis, P Sears, AK Clifton, GT Shumway, NM Papamichail, M Ponniah, S Peoples, GE Mittendorf, EA AF Hale, D. F. Vreeland, T. J. Perez, S. A. Berry, J. S. Ardavanis, A. Trappey, A. F. Tzonis, P. Sears, A. K. Clifton, G. T. Shumway, N. M. Papamichail, M. Ponniah, S. Peoples, G. E. Mittendorf, E. A. TI The combination of trastuzumab and HER2-directed peptide vaccines is safe in HER2-expressing breast cancer patients SO CANCER RESEARCH LA English DT Meeting Abstract C1 Brooke Army Med Ctr, San Antonio, TX USA. Canc Immunol & Immunotherapy Ctr, Athens, Greece. Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA. Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD DEC 15 PY 2012 VL 72 SU 24 MA P5-16-05 DI 10.1158/0008-5472.SABCS12-P5-16-05 PG 1 WC Oncology SC Oncology GA V43TY UT WOS:000209704901238 ER PT J AU Ferguson, JB Sheykh-Jaberi, F Kim, CS Rohatgi, PK Cho, K AF Ferguson, J. B. Sheykh-Jaberi, Fariba Kim, Chang-Soo Rohatgi, Pradeep K. Cho, Kyu TI On the strength and strain to failure in particle-reinforced magnesium metal-matrix nanocomposites (Mg MMNCs) SO MATERIALS SCIENCE AND ENGINEERING A-STRUCTURAL MATERIALS PROPERTIES MICROSTRUCTURE AND PROCESSING LA English DT Article DE Metal matrix composites; Nanocomposite; Magnesium alloys; Strength; Ductility ID ENHANCING COMPRESSIVE RESPONSE; MELTED SIC/AL COMPOSITES; NANO SIO2 PARTICLES; MECHANICAL-PROPERTIES; TENSILE PROPERTIES; AZ61 MG; MICROSTRUCTURE; ALUMINUM; ALLOY; NANOPARTICLES AB The addition of nanoparticulate (NP) reinforcements to magnesium (Mg)-based materials is considered a promising technique in improving mechanical properties beyond what can be achieved through alloying and grain refinement. In this work, we have comprehensively collected the currently available experimental data for magnesium metal-matrix nanocomposites (Mg MMNCs) and performed analyses to determine the contribution of any Orowan-type strengthening, which is thought to be a primary mechanism in simultaneously improving both strength and ductility. Although studies are numerous, it was found that most of the individual reports in the literature do not provide sufficient data points to make quantitative conclusion on which mechanisms may be active. Of those that do, the analyses show that, in most cases, the enhanced strength can be accounted for by grain refinement and/or dislocation production through mechanical post-processing, such as hot-rolling, with little indication of Orowan strengthening. A comparison with hot-rolled Mg AZ31 alloy specimens demonstrates that the degree of grain refinement in Mg MMNCs is comparable to that achieved by traditional processing routes. In Mg MMNCs with higher yield strength than the AZ31 specimens of comparable grain size, the MMNC typically demonstrated significantly lower ductility indicating that yield strength improvements by mechanical post-processing have resulted in the expected decrease in ductility that accompanies increased dislocation density. (C) 2012 Elsevier B.V. All rights reserved. C1 [Ferguson, J. B.; Sheykh-Jaberi, Fariba; Kim, Chang-Soo; Rohatgi, Pradeep K.] Univ Wisconsin, Dept Mat, Milwaukee, WI 53211 USA. [Cho, Kyu] USA, Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. RP Kim, CS (reprint author), Univ Wisconsin, Dept Mat, 3200 N Cramer St, Milwaukee, WI 53211 USA. EM kimcs@uwm.edu FU U.S. Army Research Laboratory (US ARL) [W911NF-08-2-0014]; UWM Research Growth Initiative Award FX This material is based upon work supported by the U.S. Army Research Laboratory (US ARL) under Cooperative Agreement No. W911NF-08-2-0014. The views, opinions, and conclusions made in this document are those of the authors and should not be interpreted as representing the official policies, either expressed or implied, of Army Research Laboratory or the U.S. Government. The U.S. Government is authorized to reproduce and distribute reprints for Government purposes notwithstanding any copyright notation herein. PK Rohatgi and C-S Kim also acknowledge the support by the UWM Research Growth Initiative Award. NR 67 TC 37 Z9 37 U1 6 U2 60 PU ELSEVIER SCIENCE SA PI LAUSANNE PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND SN 0921-5093 J9 MAT SCI ENG A-STRUCT JI Mater. Sci. Eng. A-Struct. Mater. Prop. Microstruct. Process. PD DEC 15 PY 2012 VL 558 BP 193 EP 204 DI 10.1016/j.msea.2012.07.111 PG 12 WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Science & Technology - Other Topics; Materials Science; Metallurgy & Metallurgical Engineering GA 039MJ UT WOS:000311249800028 ER PT J AU Atwater, MA Roy, D Darling, KA Butler, BG Scattergood, RO Koch, CC AF Atwater, Mark A. Roy, Debdas Darling, Kristopher A. Butler, Brady G. Scattergood, Ronald O. Koch, Carl C. TI The thermal stability of nanocrystalline copper cryogenically milled with tungsten SO MATERIALS SCIENCE AND ENGINEERING A-STRUCTURAL MATERIALS PROPERTIES MICROSTRUCTURE AND PROCESSING LA English DT Article DE Nanocrystalline; Copper; Tungsten; Stabilization; Grain boundary pinning; Strengthening ID REDUCING GRAIN-BOUNDARY; MICROSTRUCTURAL STABILITY; MECHANICAL-PROPERTIES; SOLUTE SEGREGATION; ZENER DRAG; W ALLOYS; CU; GROWTH; ENERGY; STABILIZATION AB Copper (Cu) was cryogenically milled with tungsten (W) in a high-energy ball mill. The process created W particles dispersed in a nanocrystalline Cu matrix. These "alloys" were then annealed to a maximum temperature of 800 degrees C. The addition of W stabilized the Cu at similar to 40 nm during annealing to 400 degrees C for a 1 at% W composition and to 600 degrees C for 10 at% W. As evidenced through hardness measurement, the W provided a significant increase in strength over pure Cu, and the 10 at% W material maintained a 2.6 GPa hardness after annealing at 800 degrees C. The stabilization and strengthening mechanisms are compared against theoretical prediction and found to be in good agreement. Although the strength and stability are significantly improved over pure Cu, the maximum benefit was hindered by an extremely broad W particle size distribution (similar to 5-5000 nm). For the 10 at% W alloy, only half of the added W was reduced to nanoscale where kinetic pinning and strengthening become most effective. (C) 2012 Elsevier B.V. All rights reserved. C1 [Atwater, Mark A.; Roy, Debdas; Scattergood, Ronald O.; Koch, Carl C.] N Carolina State Univ, Dept Mat Sci & Engn, Raleigh, NC 27606 USA. [Atwater, Mark A.; Darling, Kristopher A.; Butler, Brady G.] USA, Res Lab, Weap & Mat Res Directorate, RDRL WMM F, Aberdeen Proving Ground, MD 21005 USA. [Roy, Debdas] NIFFT, Mat & Met Engn Dept, Ranchi 834003, Bihar, India. RP Atwater, MA (reprint author), N Carolina State Univ, Dept Mat Sci & Engn, 911 Partners Way,EB 1,Room 3002, Raleigh, NC 27606 USA. EM maatwat2@ncsu.edu FU Office of Naval Research [N00014-10-1-0168] FX The authors wish to acknowledge the support of this research by the Office of Naval Research under Grant no. N00014-10-1-0168. NR 51 TC 22 Z9 22 U1 2 U2 42 PU ELSEVIER SCIENCE SA PI LAUSANNE PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND SN 0921-5093 J9 MAT SCI ENG A-STRUCT JI Mater. Sci. Eng. A-Struct. Mater. Prop. Microstruct. Process. PD DEC 15 PY 2012 VL 558 BP 226 EP 233 DI 10.1016/j.msea.2012.07.117 PG 8 WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Science & Technology - Other Topics; Materials Science; Metallurgy & Metallurgical Engineering GA 039MJ UT WOS:000311249800032 ER PT J AU He, QG Ren, XM AF He, Qinggang Ren, Xiaoming TI Scanning probe imaging of surface ion conductance in an anion exchange membrane SO JOURNAL OF POWER SOURCES LA English DT Article DE Anion exchange membrane; Current sensing SPM; Ionic conductivity; Fuel cells ID ALKALINE FUEL-CELLS; TRANSPORT-PROPERTIES; WATER AB The goal of this study was to investigate surface ion conductance variation in an anion-exchange membrane (AEM) using current-sensing scanning probe microscopy. No direct correlation was found between the membrane surface topography and local ion conductance. Smaller and larger conducting areas associated with ion channels and ionic clusters were identified in images of membrane surface ion conductance. Both the size of ion channels and the density of ionic clusters tended to increase significantly at higher relative humidity (RH) conditions. The ionic conductance of the AEM was one order of magnitude lower than its proton-exchange counterpart (Nafion (R)) at 100% relative humidity. This decrease may be due to the rate-limiting properties of the studied AEM, such as lower mobility of anions (HCO3- and OH-), smaller size of ionic channels, lower density of ionic clusters, and lower capability for water uptake as compared to Nafion (R) 212. Nevertheless, the ionic conductance was found robe higher on the AEM when the RH was lower than 45%. These results have direct implications for the application of the AEM in fuel cells without humidification systems. Published by Elsevier B.V. C1 [He, Qinggang] Univ Calif Berkeley, Lawrence Berkeley Natl Lab, Environm Energy Technol Div, Berkeley, CA 94720 USA. [Ren, Xiaoming] USA, Res Lab, RDRL SED C, Adelphi, MD 20783 USA. RP He, QG (reprint author), Univ Calif Berkeley, Lawrence Berkeley Natl Lab, Environm Energy Technol Div, 1 Cyclotron Rd, Berkeley, CA 94720 USA. EM hqgma2008@gmail.com; xiaoming.ren.civ@mail.mil RI ren, xiaoming/F-3953-2011; He, Qinggang/O-7639-2014 OI He, Qinggang/0000-0002-7693-8017 FU Office of Hydrogen, Fuel Cells and Infrastructure Technologies of the U.S. Department of Energy [DE-AC02-05CH11231] FX This work was supported by the Assistant Secretary for Energy Efficiency and Renewable Energy, Office of Hydrogen, Fuel Cells and Infrastructure Technologies of the U.S. Department of Energy under Contract No. DE-AC02-05CH11231. We also thank Dr. Frank Mclarnon and Mr. Kyle Clark for helpful comments and suggestions during preparation of this manuscript. NR 21 TC 6 Z9 6 U1 0 U2 35 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0378-7753 J9 J POWER SOURCES JI J. Power Sources PD DEC 15 PY 2012 VL 220 BP 373 EP 376 DI 10.1016/j.jpowsour.2012.07.039 PG 4 WC Chemistry, Physical; Electrochemistry; Energy & Fuels; Materials Science, Multidisciplinary SC Chemistry; Electrochemistry; Energy & Fuels; Materials Science GA 022UW UT WOS:000309990300051 ER PT J AU Wagner, GW Xega, R AF Wagner, George W. Xega, Roberta TI Mitigation of VX Effluents in Thorough Decontamination Operations SO INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH LA English DT Article ID CHEMICAL WARFARE AGENTS; MASS-SPECTROMETRY; DEGRADATION; CONCRETE; HYDROLYSIS; KINETICS; AMBIENT AB Effluents resulting from the decontamination of VX from CARC-painted panels using DF200 have been studied to determine the presence of toxic species. The effect of concrete and sand (two possible sump materials) on the effluents is also examined. Wash-effluents, generated by washing the panel with hot soapy water prior to decontamination, contain high levels of VX which slowly hydrolyze to nontoxic EMPTA, EMPA, and toxic EA-2192, with concrete tending to minimize formation of the latter. Rinse-effluents, generated following decontamination, contain lower levels of VX which tend to fall below acceptable levels (20 ppb) within several hours in contact with sand. VX in rinse-effluents in contact with concrete persists for up to a week, consistent with the decomposition by concrete of active H2O2 in any residual DF200. EA-2192 persists for at least a week in rinse-effluents-in contact with either sand or concrete. Lining sump pits with HTH is a possible mitigation strategy as this decontaminant readily oxidizes residual VX, EA-2192, and even EMPTA to nontoxic EMPA and MPA. C1 [Wagner, George W.; Xega, Roberta] USA, Edgewood Chem Biol Ctr, Attn RDCB DRP F, Aberdeen Proving Ground, MD 21010 USA. RP Wagner, GW (reprint author), USA, Edgewood Chem Biol Ctr, Attn RDCB DRP F, Aberdeen Proving Ground, MD 21010 USA. EM george.w.wagner22.civ@mail.mil FU Defense Threat Reduction Agency (DTRA) [BB11PHM154] FX We thank Dr. Carol A.S. Brevett for many helpful discussions on the fate of VX in sand. Support of this work was provided through the Defense Threat Reduction Agency (DTRA) under Project No. BB11PHM154. NR 22 TC 1 Z9 1 U1 0 U2 21 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0888-5885 J9 IND ENG CHEM RES JI Ind. Eng. Chem. Res. PD DEC 12 PY 2012 VL 51 IS 49 BP 16146 EP 16150 DI 10.1021/ie301836q PG 5 WC Engineering, Chemical SC Engineering GA 073UX UT WOS:000313769700035 ER PT J AU Heo, J Kang, T Jang, SG Hwang, DS Spruell, JM Killops, KL Waite, JH Hawker, CJ AF Heo, Jinhwa Kang, Taegon Jang, Se Gyu Hwang, Dong Soo Spruell, Jason M. Killops, Kato L. Waite, J. Herbert Hawker, Craig J. TI Improved Performance of Protected Catecholic Polysiloxanes for Bioinspired Wet Adhesion to Surface Oxides SO JOURNAL OF THE AMERICAN CHEMICAL SOCIETY LA English DT Article ID ENE CLICK CHEMISTRY; MUSSEL ADHESION; MYTILUS-EDULIS; ACID CATALYSTS; PROTEIN FILMS; LEWIS-ACID; L-DOPA; HYDROSILATION; LITHOGRAPHY; EFFICIENT AB A facile synthetic strategy for introducing catecholic moieties into polymeric materials based on a readily available precursor (eugenol) and efficient chemistries [tris-(pentafluorophenyl)borane-catalyzed silation and thiol-ene coupling] is reported. Silyl protection is shown to be critical for the oxidative stability of catecholic moieties during synthesis and processing, which allows functionalized polysiloxane derivatives to be fabricated into 3D microstructures as well as 2D patterned surfaces. Deprotection gives stable catechol surfaces whose adhesion to a variety of oxide surfaces can be precisely tuned by the level of catechol incorporation. The advantage of silyl protection for catechol-functionalized polysiloxanes is demonstrated and represents a promising and versatile new platform for underwater surface treatments. C1 [Heo, Jinhwa; Kang, Taegon; Jang, Se Gyu; Spruell, Jason M.; Waite, J. Herbert; Hawker, Craig J.] Univ Calif Santa Barbara, Mat Res Lab, Santa Barbara, CA 93106 USA. [Heo, Jinhwa; Kang, Taegon; Hawker, Craig J.] Univ Calif Santa Barbara, Dept Mat, Santa Barbara, CA 93106 USA. [Waite, J. Herbert; Hawker, Craig J.] Univ Calif Santa Barbara, Dept Chem & Biochem, Santa Barbara, CA 93106 USA. [Waite, J. Herbert] Univ Calif Santa Barbara, Dept Mol Cell & Dev Biol, Santa Barbara, CA 93106 USA. [Hwang, Dong Soo] Pohang Univ Sci & Technol, Ocean Sci & Technol Inst, Pohang 790784, South Korea. [Hawker, Craig J.] King Fahd Univ Petr & Minerals, Ctr Refining & Petrochem, Dhahran 31261, Saudi Arabia. [Killops, Kato L.] USA, Edgewood Chem Biol Ctr, Resarch Dev & Engn Command, Aberdeen Proving Ground, MD 21010 USA. RP Hawker, CJ (reprint author), Univ Calif Santa Barbara, Mat Res Lab, Santa Barbara, CA 93106 USA. EM hawker@mrl.ucsb.edu RI Hwang, Dong Soo/C-7291-2011 OI Hwang, Dong Soo/0000-0002-2487-2255 FU National Science Foundation (MRSEC Program) [DMR-1121053]; Institute for Collaborative Biotechnologies from the U.S. Army Research Office [W911NF-07-1-0279, W911NF-09-D-0001]; National Institutes of Health [R01 DE018468]; Samsung FX This material is based upon work supported by the National Science Foundation (MRSEC Program, DMR-1121053, supporting J.H., T.K., J.M.S., J.H.W., and C.J.H.). This work was also partially supported by the Institute for Collaborative Biotechnologies through Grants W911NF-07-1-0279 and W911NF-09-D-0001 from the U.S. Army Research Office (S.G.J., K.L.K., and C.J.H.), the National Institutes of Health (R01 DE018468 to J.H.W.), and fellowship support from Samsung (to T.K.). NR 59 TC 41 Z9 42 U1 12 U2 171 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0002-7863 J9 J AM CHEM SOC JI J. Am. Chem. Soc. PD DEC 12 PY 2012 VL 134 IS 49 BP 20139 EP 20145 DI 10.1021/ja309044z PG 7 WC Chemistry, Multidisciplinary SC Chemistry GA 054NR UT WOS:000312351000035 PM 23181614 ER PT J AU Reddy, ALM Nagarajan, S Chumyim, P Gowda, SR Pradhan, P Jadhav, SR Dubey, M John, G Ajayan, PM AF Reddy, Arava Leela Mohana Nagarajan, Subbiah Chumyim, Porramate Gowda, Sanketh R. Pradhan, Padmanava Jadhav, Swapnil R. Dubey, Madan John, George Ajayan, Pulickel M. TI Lithium storage mechanisms in purpurin based organic lithium ion battery electrodes SO SCIENTIFIC REPORTS LA English DT Article ID RECHARGEABLE BATTERIES; CATHODE; NANOWIRE; OPPORTUNITIES AB Current lithium batteries operate on inorganic insertion compounds to power a diverse range of applications, but recently there is a surging demand to develop environmentally friendly green electrode materials. To develop sustainable and eco-friendly lithium ion batteries, we report reversible lithium ion storage properties of a naturally occurring and abundant organic compound purpurin, which is non-toxic and derived from the plant madder. The carbonyl/hydroxyl groups present in purpurin molecules act as redox centers and reacts electrochemically with Li-ions during the charge/discharge process. The mechanism of lithiation of purpurin is fully elucidated using NMR, UV and FTIR spectral studies. The formation of the most favored six membered binding core of lithium ion with carbonyl groups of purpurin and hydroxyl groups at C-1 and C-4 positions respectively facilitated lithiation process, whereas hydroxyl group at C-2 position remains unaltered. C1 [Reddy, Arava Leela Mohana; Chumyim, Porramate; Gowda, Sanketh R.; Ajayan, Pulickel M.] Rice Univ, Dept Mech Engn & Mat Sci, Houston, TX 77005 USA. [Nagarajan, Subbiah; Pradhan, Padmanava; Jadhav, Swapnil R.; John, George] CUNY City Coll, Dept Chem, New York, NY 10031 USA. [Dubey, Madan] USA, Res Lab, Adelphi, MD 20783 USA. RP Reddy, ALM (reprint author), Rice Univ, Dept Mech Engn & Mat Sci, Houston, TX 77005 USA. EM leela@rice.edu; john@sci.ccny.cuny.edu; ajayan@rice.edu RI Arava, Leela Mohana Reddy/J-3180-2015; OI Subbiah, Nagarajan/0000-0003-2233-4872 FU Army Research Office; NSF-CBET; PSC-CUNY FX ALMAR and PMA express their sincere gratitude to Army Research Office for providing the funding for this work. SN and GJ acknowledges the support from NSF-CBET and PSC-CUNY Awards. NR 30 TC 31 Z9 32 U1 10 U2 94 PU NATURE PUBLISHING GROUP PI LONDON PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND SN 2045-2322 J9 SCI REP-UK JI Sci Rep PD DEC 11 PY 2012 VL 2 AR 960 DI 10.1038/srep00960 PG 5 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 053MD UT WOS:000312274900009 PM 23233879 ER PT J AU Mait, JN AF Mait, Joseph N. TI Midlife and transitioning through it SO APPLIED OPTICS LA English DT Editorial Material C1 USA, Res Lab, Washington, DC USA. RP Mait, JN (reprint author), USA, Res Lab, Washington, DC USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1559-128X EI 2155-3165 J9 APPL OPTICS JI Appl. Optics PD DEC 10 PY 2012 VL 51 IS 35 BP ED13 EP ED14 DI 10.1364/AO.51.00ED13 PG 2 WC Optics SC Optics GA 054XL UT WOS:000312378700001 PM 23262548 ER PT J AU Kvitko, BH Cox, CR DeShazer, D Johnson, SL Voorhees, KJ Schweizer, HP AF Kvitko, Brian H. Cox, Christopher R. DeShazer, David Johnson, Shannon L. Voorhees, Kent J. Schweizer, Herbert P. TI phi X216, a P2-like bacteriophage with broad Burkholderia pseudomallei and B. mallei strain infectivity SO BMC MICROBIOLOGY LA English DT Article DE Bacteriophage; Burkholderia pseudomallei; B. mallei; P2; Prophage distribution; Phage-based diagnostics ID MELIOIDOSIS; EPIDEMIOLOGY; PLASTICITY; DIVERSITY; GLANDERS; PROPHAGE; AGENT AB Background: Burkholderia pseudomallei and B. mallei are closely related Category B Select Agents of bioterrorism and the causative agents of the diseases melioidosis and glanders, respectively. Rapid phage-based diagnostic tools would greatly benefit early recognition and treatment of these diseases. There is extensive strain-to-strain variation in B. pseudomallei genome content due in part to the presence or absence of integrated prophages. Several phages have previously been isolated from B. pseudomallei lysogens, for example phi K96243, phi 1026b and phi 52237. Results: We have isolated a P2-like bacteriophage, phi X216, which infects 78% of all B. pseudomallei strains tested. phi X216 also infects B. mallei, but not other Burkholderia species, including the closely related B. thailandensis and B. oklahomensis. The nature of the phi X216 host receptor remains unclear but evidence indicates that in B. mallei phi X216 uses lipopolysaccharide O-antigen but a different receptor in B. pseudomallei. The 37,637 bp genome of phi X216 encodes 47 predicted open reading frames and shares 99.8% pairwise identity and an identical strain host range with bacteriophage phi 52237. Closely related P2-like prophages appear to be widely distributed among B. pseudomallei strains but both phi X216 and phi 52237 readily infect prophage carrying strains. Conclusions: The broad strain infectivity and high specificity for B. pseudomallei and B. mallei indicate that phi X216 will provide a good platform for the development of phage-based diagnostics for these bacteria. C1 [Kvitko, Brian H.; Schweizer, Herbert P.] Colorado State Univ, Dept Microbiol Immunol & Pathol, Ft Collins, CO 80523 USA. [Cox, Christopher R.; Voorhees, Kent J.] Colorado Sch Mines, Dept Chem & Geochem, Golden, CO 80401 USA. [DeShazer, David] USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. [Johnson, Shannon L.] Los Alamos Natl Lab, Genome Sci Grp, Joint Genom Inst, Los Alamos, NM USA. RP Schweizer, HP (reprint author), Colorado State Univ, Dept Microbiol Immunol & Pathol, IDRC Foothills Campus, Ft Collins, CO 80523 USA. EM Herbert.Schweizer@colostate.edu FU Defense Threat Reduction Agency [W81XWH-07-C0061] FX Funding was provided by the Defense Threat Reduction Agency grant W81XWH-07-C0061. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 29 TC 6 Z9 6 U1 0 U2 10 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1471-2180 J9 BMC MICROBIOL JI BMC Microbiol. PD DEC 7 PY 2012 VL 12 AR 289 DI 10.1186/1471-2180-12-289 PG 10 WC Microbiology SC Microbiology GA 075JT UT WOS:000313882200001 PM 23217012 ER PT J AU Wigelsworth, DJ Ruthel, G Schnell, L Herrlich, P Blonder, J Veenstra, TD Carman, RJ Wilkins, TD Guy, TVN Pauillac, S Gibert, M Sauvonnet, N Stiles, BG Popoff, MR Barth, H AF Wigelsworth, Darran J. Ruthel, Gordon Schnell, Leonie Herrlich, Peter Blonder, Josip Veenstra, Timothy D. Carman, Robert J. Wilkins, Tracy D. Guy Tran Van Nhieu Pauillac, Serge Gibert, Maryse Sauvonnet, Nathalie Stiles, Bradley G. Popoff, Michel R. Barth, Holger TI CD44 Promotes Intoxication by the Clostridial Iota-Family Toxins SO PLOS ONE LA English DT Article ID BOTULINUM C2 TOXIN; LIPID RAFTS; BIOLOGICAL-ACTIVITY; SPIROFORME TOXIN; BINDING DOMAIN; ANTHRAX TOXIN; VERO CELLS; RECEPTOR; ACTIN; PROTEINS AB Various pathogenic clostridia produce binary protein toxins associated with enteric diseases of humans and animals. Separate binding/translocation (B) components bind to a protein receptor on the cell surface, assemble with enzymatic (A) component(s), and mediate endocytosis of the toxin complex. Ultimately there is translocation of A component(s) from acidified endosomes into the cytosol, leading to destruction of the actin cytoskeleton. Our results revealed that CD44, a multifunctional surface protein of mammalian cells, facilitates intoxication by the iota family of clostridial binary toxins. Specific antibody against CD44 inhibited cytotoxicity of the prototypical Clostridium perfringens iota toxin. Versus CD44(+) melanoma cells, those lacking CD44 bound less toxin and were dose-dependently resistant to C. perfringens iota, as well as Clostridium difficile and Clostridium spiroforme iota-like, toxins. Purified CD44 specifically interacted in vitro with iota and iota-like, but not related Clostridium botulinum C2, toxins. Furthermore, CD44 knockout mice were resistant to iota toxin lethality. Collective data reveal an important role for CD44 during intoxication by a family of clostridial binary toxins. C1 [Stiles, Bradley G.] Wilson Coll, Dept Biol, Chambersburg, PA 17201 USA. [Ruthel, Gordon] Univ Penn, Core Imaging Facil, Sch Vet Med, Philadelphia, PA 19104 USA. [Schnell, Leonie; Barth, Holger] Univ Ulm, Inst Pharmacol & Toxicol, Med Ctr, Ulm, Germany. [Wigelsworth, Darran J.] USA, Med Res Inst Infect Dis, Integrated Toxicol Div, Frederick, MD USA. [Herrlich, Peter] Fritz Lipmann Inst, Leibniz Inst Age Res, Jena, Germany. [Blonder, Josip; Veenstra, Timothy D.] NCI, Lab Prote & Analyt Technol, Frederick, MD 21701 USA. [Carman, Robert J.; Wilkins, Tracy D.] TechLab Inc, Blacksburg, VA USA. [Guy Tran Van Nhieu] Coll France, Dept Intracellular Commun & Infect Microorgan, F-75231 Paris, France. [Pauillac, Serge; Gibert, Maryse; Popoff, Michel R.] Inst Pasteur, Unite Bacteries Anaerobies & Toxines, Paris, France. [Sauvonnet, Nathalie] Inst Pasteur, Unite Biol Interact Cellulaires, Paris, France. RP Stiles, BG (reprint author), Wilson Coll, Dept Biol, Chambersburg, PA 17201 USA. EM bstiles@wilson.edu; mpopoff@pasteur.fr; holger.barth@uni-ulm.de RI Barth, Holger/E-7920-2013; Popoff, Michel/O-7719-2016 OI Popoff, Michel/0000-0001-9305-8989 FU Institut Pasteur; Faculty Fund for Research at Wilson College; Faculty of Medicine at the University of Ulm plus Deutsche Forschungsgemeinschaft (DFG) [BA 2087/2-1] FX Funding was provided in part by the Institut Pasteur (MRP), Faculty Fund for Research at Wilson College (BGS), as well as the Faculty of Medicine at the University of Ulm plus Deutsche Forschungsgemeinschaft (DFG grant BA 2087/2-1) to HB. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 60 TC 13 Z9 13 U1 0 U2 12 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD DEC 7 PY 2012 VL 7 IS 12 AR e51356 DI 10.1371/journal.pone.0051356 PG 9 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 050OT UT WOS:000312064100104 PM 23236484 ER PT J AU Rubal, BJ Meyers, BL Kramer, SA Pomeroy, WL DeLorenzo, RA AF Rubal, Bernard J. Meyers, Belinda L. Kramer, Sarah A. Pomeroy, William L. DeLorenzo, Robert A. TI Intravascular Flocculation and Sequestration of Bone Marrow Fat and Thromboembolic Events Associated With Intraosseous Infusions SO CIRCULATION LA English DT Meeting Abstract CT Scientific Sessions of the American-Heart-Association CY NOV 03-07, 2012 CL Los Angeles, CA SP Amer Heart Assoc DE Embolism; Resuscitation; Research C1 [Rubal, Bernard J.; Kramer, Sarah A.; Pomeroy, William L.] San Antonio Mil Med Ctr, Ft Sam Houston, TX USA. [Meyers, Belinda L.; DeLorenzo, Robert A.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0009-7322 J9 CIRCULATION JI Circulation PD DEC 4 PY 2012 VL 126 IS 23 BP 2795 EP 2795 PG 1 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 048TY UT WOS:000311937200069 ER PT J AU Lattao, C Cao, X Li, Y Mao, J Schmidt-Rohr, K Chappell, MA Miller, LF dela Cruz, AL Pignatello, JJ AF Lattao, Charisma Cao, Xiaoyan Li, Yuan Mao, Jingdong Schmidt-Rohr, Klaus Chappell, Mark A. Miller, Lesley F. dela Cruz, Albert Leo Pignatello, Joseph J. TI Sorption Selectivity in Natural Organic Matter Studied with Nitroxyl Paramagnetic Relaxation Probes SO ENVIRONMENTAL SCIENCE & TECHNOLOGY LA English DT Article ID NUCLEAR-MAGNETIC-RESONANCE; BLACK CARBON CHAR; ADSORPTIVE PROPERTIES; HUMIC SUBSTANCES; HYDROGEN-BOND; SPIN-PROBE; C-13 NMR; DOMAINS; SOIL; POLYMER AB Sorption site selectivity and mechanism in natural organic matter (NOM) were addressed spectroscopically by the sorption of paramagnetic nitroxyl compounds (spin probes) of different polarity, TEMPO (2,2,6,6-tetramethylpiperidine-1-oxyl) and HTEMPO (4-hydroxy-2,2,6,6-tetramethylpiperidine-1-oxyl). The sorbents were Pahokee peat, Beulah-Zap lignite, and a polystyrene-poly(vinyl methyl ether) (PS-PVME) polymer blend representing the mixed aliphatic-aromatic, polar-nonpolar character of NOM. Nuclear-electron spin interaction serves as an efficient relaxation pathway, resulting in attenuation of the C-13-CP/TOSS NMR signal for C-13 nuclei in proximity to the N-O. group (r(-6) dependence). In the natural solids the spin probes sorbed more specifically (greater isotherm nonlinearity) and had lower rotational mobility (broader electron paramagnetic resonance signals) than in PS-PVME. Titration with spin probe indicated almost no selectivity for the different carbon functional groups of PS-PVME, and little to no selectivity for the different carbon moieties of Pahokee and Beulah, including aromatic, alkyl, O-alkyl, di-O-alkyl, and O-methyl. In any case, sorption site selectivity of spin probes to NOM was always weaker than partition selectivity found in model solvent-water (toluene, hexadecane, anisole, octanol) and cellulose-water systems. The results indicate little or no preferential sorption in NOM based on functional group chemistry or putative microdomain character, but rather are consistent with the filling of pores whose walls have an average chemical environment reflecting the bulk chemical composition of the solid. This work demonstrates for the first time the use of paramagnetic probes to study sorption specificity. C1 [Lattao, Charisma; Pignatello, Joseph J.] Connecticut Agr Expt Stn, Dept Environm Sci, New Haven, CT 06504 USA. [Cao, Xiaoyan; Li, Yuan; Mao, Jingdong] Old Dominion Univ, Dept Chem & Biochem, Norfolk, VA 23529 USA. [Schmidt-Rohr, Klaus] Iowa State Univ, Dept Chem, Ames, IA 50010 USA. [Chappell, Mark A.; Miller, Lesley F.] USA, Environm Lab, Corps Engineers, Vicksburg, MS 39180 USA. [dela Cruz, Albert Leo] Louisiana State Univ, LSU Superfund Res Ctr, Baton Rouge, LA 70802 USA. RP Pignatello, JJ (reprint author), Connecticut Agr Expt Stn, Dept Environm Sci, POB 1106, New Haven, CT 06504 USA. EM Joseph.Pignatello@ct.gov RI Cao, Xiaoyan/E-3492-2012 OI Cao, Xiaoyan/0000-0001-7571-6482 FU National Science Foundation [CBET 0853682, 0853950] FX This work was supported by the National Science Foundation (CBET 0853682 and 0853950). We thank Dr. Barry Dellinger and the LSU Superfund Research Center for access to the EPR Spectroscopy Facility. NR 45 TC 11 Z9 11 U1 2 U2 53 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0013-936X EI 1520-5851 J9 ENVIRON SCI TECHNOL JI Environ. Sci. Technol. PD DEC 4 PY 2012 VL 46 IS 23 BP 12814 EP 12822 DI 10.1021/es302157j PG 9 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA 047AT UT WOS:000311810800009 PM 23078290 ER PT J AU Rinderspacher, BC Andzelm, JW Lambeth, RH AF Rinderspacher, B. Christopher Andzelm, Jan W. Lambeth, Robert H. TI DFT study of metal-complex structural variation on tensile force profiles SO CHEMICAL PHYSICS LETTERS LA English DT Article ID MOLECULAR-DYNAMICS SIMULATIONS; SUPRAMOLECULAR POLYMERS; DENSITY FUNCTIONALS; ETHANE DISSOCIATION; TRANSITION; THERMOCHEMISTRY; NANOMECHANICS; MECHANISMS; DESIGN; STATE AB We present calculations on metal-ligand complexes for the evaluation of mechanical properties as they pertain to the inclusion in polymer-linked supramolecular complexes. To this end, we investigate the energy profiles of stretching various complexes according to external forces exerted on each complex via the attached polymer strands. Zn2+ and Fe2+ complexated by 2,6-bisbenzimidazolyl-pyridine (BP) were considered in the presence of tetrafluoro borate. We find that the yield characteristics are subject to a complex interplay of steric and electronic effects of the ligands and metal center. Published by Elsevier B.V. C1 [Rinderspacher, B. Christopher; Andzelm, Jan W.; Lambeth, Robert H.] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Rinderspacher, BC (reprint author), USA, Res Lab, 4600 Deer Creek Lp, Aberdeen Proving Ground, MD 21005 USA. EM berend.c.rinderspacher.civ@mail.mil NR 48 TC 2 Z9 2 U1 1 U2 26 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0009-2614 EI 1873-4448 J9 CHEM PHYS LETT JI Chem. Phys. Lett. PD DEC 3 PY 2012 VL 554 BP 96 EP 101 DI 10.1016/j.cplett.2012.09.030 PG 6 WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical SC Chemistry; Physics GA 036PE UT WOS:000311039500018 ER PT J AU Fu, Q Montoya, LF Solanki, A Nasiri, A Bhavaraju, V Abdallah, T Yu, DC AF Fu, Qiang Montoya, Luis F. Solanki, Ashish Nasiri, Adel Bhavaraju, Vijay Abdallah, T. Yu, David C. TI Microgrid Generation Capacity Design With Renewables and Energy Storage Addressing Power Quality and Surety SO IEEE TRANSACTIONS ON SMART GRID LA English DT Article DE Distributed generation; high penetration renewable; microgrid; power quality; renewable energy; smart grid AB Microgrids are receiving attention due to the increasing need to integrate distributed generations and to insure power quality and to provide energy surety to critical loads. Since renewables need to be in the mix for energy surety, a high renewable-energy penetrated microgrid is analyzed in this paper. The standard IEEE 34 bus distribution feeder is adapted and managed as a microgrid by adding distributed generation and load profiles. The 25 kV system parameters are scaled down to 12 kV and renewable sources including solar PV and wind turbines, an energy storage system, and a diesel generator for islanded mode have been added to the 34-bus system. The distribution generations (DG) and renewables are modeled in detail using PSCAD software and practical constraints of the components are considered. The monitoring of the microgrid for measuring power quality and control requirements for these DGs and storage are modeled to maintain the power quality of the system when loads are varied. Renewable sources are modeled with seasonal variation at different locations. The microgrid is monitored at number of buses and the power quality issues are measured and indexes are calculated. This paper proposes a generalized approach to design (determine the capacity requirements) and demonstrates the management of microgrids with metrics to meet the power quality indexes. C1 [Fu, Qiang; Montoya, Luis F.; Solanki, Ashish; Nasiri, Adel; Yu, David C.] Univ Wisconsin, Milwaukee, WI 53201 USA. [Bhavaraju, Vijay] Eaton Corp Innovat Ctr, Milwaukee, WI 53216 USA. [Abdallah, T.] US Army, Champaign, IL 61822 USA. RP Fu, Q (reprint author), Univ Wisconsin, Milwaukee, WI 53201 USA. EM nasiri@uwm.edu; VijayBhavaraju@eaton.com; tarek.abdallah@erdc.usace.army.mil FU U.S. Army Corps of Engineers (ERDC/CERL) [W9132T-11-C-0022] FX This material is based upon work supported by the U.S. Army Corps of Engineers (ERDC/CERL) under Contract W9132T-11-C-0022. Any opinions, findings, and conclusions or recommendations expressed in this material are those of the author(s) and do not necessarily reflect the views of the U.S. Army Corps of Engineers. NR 16 TC 58 Z9 60 U1 2 U2 22 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1949-3053 J9 IEEE T SMART GRID JI IEEE Trans. Smart Grid PD DEC PY 2012 VL 3 IS 4 BP 2019 EP 2027 DI 10.1109/TSG.2012.2223245 PG 9 WC Engineering, Electrical & Electronic SC Engineering GA 232HY UT WOS:000325485000047 ER PT J AU Rutvisuttinunt, W Sirivichayakul, S Oota, S Assawadarachai, V Poltavee, K Savadsuk, H Pattanachaiwit, S Chaemchuen, S Arroyo, MA Paris, RM Michael, NL Kim, JH Ruxrungtham, K de Souza, M Phanuphak, P Tovanabutra, S AF Rutvisuttinunt, Wiriya Sirivichayakul, Sunee Oota, Sineenart Assawadarachai, Vatcharain Poltavee, Kultida Savadsuk, Hathairat Pattanachaiwit, Supanit Chaemchuen, Suwittra Arroyo, Miguel A. Paris, Robert M. Michael, Nelson L. Kim, Jerome H. Ruxrungtham, Kiat de Souza, Mark Phanuphak, Praphan Tovanabutra, Sodsai TI Two Unique Recombinant Forms Identified in Incident HIV Type 1 Infections in Thai Blood Donors SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Article ID MOLECULAR EPIDEMIOLOGY; RISK POPULATIONS; DRUG-USERS; TRANSMISSION; RESISTANCE; CRF33-01B; SURVEILLANCE; PREVALENCE; DIVERSITY; SINGAPORE AB HIV-1 genetic diversity of recently seroconverting (<12 months) Thai repeated blood donors attending the National Blood Centre, Thai Red Cross Society (NBC, TRCS) from September 2007 until March 2008 was assessed. Ten HIV-1 recent seroconvertors (10/239,134 donations) were identified during the study period. The estimated median time to seroconversion was 67.3 days (range: 45.5-102.0 days), and viral load ranged from 307 to 341,805 copies HIV-1 RNA/ml. MHAbce, a real-time-based PCR genotyping assay, identified six CRF01_AE, two CRF01_AE/B recombinants, one subtype B, and one CRF01_AE/B dual infection. Nine samples were further characterized by full genome sequencing, identifying CRF01_AE (N=6), unique CRF01_AE/B recombinants (N=2), and subtype B (N=1). One recombinant contained 13 breakpoints located in gag, pol, vif, vpr, env, and nef while the other recombinant contained 10 breakpoints located in pol, vif, env, and nef. This study found two unique CRF01B recombinants circulating in 10 recent HIV-1-positive subjects from a blood donor population in Thailand. C1 [Rutvisuttinunt, Wiriya; Assawadarachai, Vatcharain; Poltavee, Kultida; Savadsuk, Hathairat; Chaemchuen, Suwittra; Arroyo, Miguel A.; Paris, Robert M.; de Souza, Mark] Armed Forces Res Inst Med Sci, Dept Retrovirol, Bangkok 10400, Thailand. [Sirivichayakul, Sunee; Ruxrungtham, Kiat; Phanuphak, Praphan] Chulalongkorn Univ, Fac Med, Dept Med, Bangkok 10330, Thailand. [Oota, Sineenart] Thai Red Cross Soc, Natl Blood Ctr, Bangkok, Thailand. [Pattanachaiwit, Supanit; Ruxrungtham, Kiat; Phanuphak, Praphan] Thai Red Cross AIDS Res Ctr, Bangkok, Thailand. [Arroyo, Miguel A.; Michael, Nelson L.; Kim, Jerome H.; de Souza, Mark; Tovanabutra, Sodsai] Walter Reed Army Inst Res, US Mil HIV Res Program, Rockville, MD USA. [Arroyo, Miguel A.] Walter Reed Natl Mil Med Ctr, Dept Pathol, Bethesda, MD USA. [Paris, Robert M.] Walter Reed Natl Mil Med Ctr, Dept Infect Dis, Bethesda, MD USA. RP Rutvisuttinunt, W (reprint author), Armed Forces Res Inst Med Sci, Dept Retrovirol, 315-6 Rajvithi Rd, Bangkok 10400, Thailand. EM wiriyar@afrims.org OI Arroyo, Miguel/0000-0001-7416-8867 FU Department of Retrovirology, AFRIMS; Military Infectious Diseases Research Program (MIDRP) [W81XWH-07-2-0067]; Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.; U.S. Department of Defense (DOD); Higher Education Research Promotion and National Research University Project of Thailand, Office of the Higher Education Commission [HR1161A5] FX We would like to thank LTC Viseth Ngauy, Dr. Joseph Chiu, Ms. Rapee Trichavaroj, the molecular laboratory, and the Department of Retrovirology, AFRIMS, for support and advice on the study. We would like to extend our thanks to Dr. Gustavo Kijak, Dr. Morgane Rolland, Mr. Eric Sanders-Buell, and the Division of Molecular Virology and Pathogenesis, MHRP, Rockville, Maryland for technical support and assistance. In addition, we would like to thank Dr. Soisaang Phikulsod, director of NBC, TRCS, Blood Testing section, Registration and Statistic section at the National Blood Centre, Thai Red Cross Society, for database information.; This work was supported by funding provided by the Military Infectious Diseases Research Program (MIDRP) through a cooperative agreement (W81XWH-07-2-0067) between the Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., and the U.S. Department of Defense (DOD). The views and opinions expressed herein do not necessarily reflect those of the U.S. Army or the Department of Defense.; In addition, part of this work was supported by the Higher Education Research Promotion and National Research University Project of Thailand (HR1161A5), Office of the Higher Education Commission. NR 44 TC 2 Z9 2 U1 0 U2 2 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0889-2229 EI 1931-8405 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD DEC PY 2012 VL 28 IS 12 BP 1703 EP 1711 DI 10.1089/aid.2011.0339 PG 9 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA 047FW UT WOS:000311825000025 PM 22587412 ER PT J AU Brooker, JW Seamone, ER Rogall, LC AF Brooker, John W. Seamone, Evan R. Rogall, Leslie C. TI BEYOND "TBD": UNDERSTANDING VA'S EVALUATION OF A FORMER SERVICEMEMBER'S BENEFIT ELIGIBILITY FOLLOWING INVOLUNTARY OR PUNITIVE DISCHARGE FROM THE ARMED FORCES SO MILITARY LAW REVIEW LA English DT Article ID VETERANS C1 [Brooker, John W.] USA, Judge Advocate Gen Sch, Washington, DC 20310 USA. [Seamone, Evan R.] Mil Justice Ft Benning, Ft Benning, GA USA. [Seamone, Evan R.] USA, Maneuver Ctr Excellence, Washington, DC USA. [Rogall, Leslie C.] Off Gen Counsel OGC, Dept Vet Affairs VA, Washington, DC USA. [Rogall, Leslie C.] Disabled Amer Vet, Judicial Appeals Off, Washington, DC USA. [Rogall, Leslie C.] USA, Judge Advocate Gen Corps, Washington, DC USA. [Rogall, Leslie C.] XVIII Airborne Corps, Ft Bragg, NC USA. [Rogall, Leslie C.] Womack Army Med Ctr, Ft Bragg, NC USA. RP Brooker, JW (reprint author), USA, Judge Advocate Gen Sch, Washington, DC 20310 USA. NR 146 TC 0 Z9 0 U1 2 U2 2 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 USA SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD WIN PY 2012 VL 214 BP 1 EP 328 PG 328 WC Law SC Government & Law GA 137TH UT WOS:000318460500001 ER PT J AU Buckner, FS Waters, NC Avery, VM AF Buckner, Frederick S. Waters, Norman C. Avery, Vicky M. TI Recent highlights in anti-protozoan drug development and resistance research SO INTERNATIONAL JOURNAL FOR PARASITOLOGY-DRUGS AND DRUG RESISTANCE LA English DT Article DE Antiparasitic drug discovery; Drug resistance; Malaria; Protozoa ID MALARIA AB This article summarizes the highlights of research presented in January, 2012, at the Keystone Symposium on "Drug Discovery for Protozoan Parasites'' held in Santa Fe, New Mexico. This symposium which convenes approximately every 2 years provides a forum for leading investigators around the world to present data covering basic sciences to clinical trials relating to anti-protozoan drug development and drug resistance. Many talks focused on malaria, but other protozoan diseases receiving attention included African sleeping sickness, Chagas disease, leishmaniasis, cryptosporidiosis, and amoebiasis. The new research, most of it unpublished, provided insights into the latest developments in the field. (C) 2012 Australian Society for Parasitology Published by Elsevier Ltd. All rights reserved. C1 [Buckner, Frederick S.] Univ Washington, Dept Med, Seattle, WA 98195 USA. [Waters, Norman C.] US Mil Acad, Dept Chem & Life Sci, West Point, NY 10996 USA. [Avery, Vicky M.] Griffith Univ, Nathan, Qld 4111, Australia. RP Buckner, FS (reprint author), Univ Washington, Hlth Sci Bldg,Room I-204, Seattle, WA 98195 USA. EM fbuckner@u.washington.edu RI Avery, Vicky/A-5449-2010 FU Keystone Symposia; Bill and Melinda Gates foundation FX We thank the Keystone Symposia, the Bill and Melinda Gates foundation, and the other generous sponsors for supporting this conference. The authors wish to thank all the scientists who gave their consent to discuss their unpublished work in this article. NR 6 TC 6 Z9 7 U1 0 U2 3 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 2211-3207 J9 INT J PARASITOL-DRUG JI Int. J. Parasitol.-Drugs Drug Resist. PD DEC PY 2012 VL 2 BP 230 EP 235 DI 10.1016/j.ijpddr.2012.05.002 PG 6 WC Parasitology; Pharmacology & Pharmacy SC Parasitology; Pharmacology & Pharmacy GA 123QH UT WOS:000317404800027 PM 24533285 ER PT J AU Pankow, M Waas, AM Yen, CF AF Pankow, M. Waas, A. M. Yen, C. F. TI Modeling the Response of 3D Textile Composites under Compressive Loads to Predict Compressive Strength SO CMC-COMPUTERS MATERIALS & CONTINUA LA English DT Article DE 3D Woven; RUC Modeling; Material Characterization ID FINITE-ELEMENT MODEL; WOVEN COMPOSITES; FAILURE; IMPACT; SIMULATION AB The compression response of 3D woven textile composites (3DWC) that consist of glass fiber tows and a polymer matrix material is studied using a combination of experiments and finite element based analyses. A previous study reported by the authors consisted of an experimental investigation of 3DWC under high strain rate loading, Pankow, Salvi, Waas, Yen, and Ghiorse (2011). Those experimental results were explained by using the finite element method to analyze the high rate deformation response of representative volume elements (RVEs) of the 3DWC, Pankow, Waas, Yen, and Ghiorse (2012). In this paper, the same modeling strategy is used to examine the quasi-static, compressive deformation response of 3DWC. The effect of using different numbers of the textile repeat unit architecture in the RYE, on the predicted compression strength, is examined. The transitions in failure modes that are seen in experiments are seen to be captured by the model that is presented here. C1 [Pankow, M.] Univ Michigan, Dept Aerosp Engn, Composite Struct Lab, Ann Arbor, MI 48109 USA. [Yen, C. F.] Army Res Lab, Aberdeen, MD USA. EM dcw@umich.edu FU Army Research Laboratory FX The authors would like to thank Army Research Laboratory for their continued financial support. NR 28 TC 5 Z9 5 U1 0 U2 24 PU TECH SCIENCE PRESS PI NORCROSS PA 6825 JIMMY CARTER BLVD, STE 1850, NORCROSS, GA 30071 USA SN 1546-2218 J9 CMC-COMPUT MATER CON JI CMC-Comput. Mat. Contin. PD DEC PY 2012 VL 32 IS 2 BP 81 EP 106 PG 26 WC Engineering, Multidisciplinary; Materials Science, Multidisciplinary; Mathematics, Interdisciplinary Applications SC Engineering; Materials Science; Mathematics GA 106SR UT WOS:000316165500002 ER PT J AU Finlayson, K AF Finlayson, Kenneth TI U.S. Army Doctrine: From the American Revolution to the War on Terror SO AMERICAN HISTORICAL REVIEW LA English DT Book Review C1 [Finlayson, Kenneth] USA, Special Operat Command, Ft Bragg, NC USA. RP Finlayson, K (reprint author), USA, Special Operat Command, Ft Bragg, NC USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 0002-8762 J9 AM HIST REV JI Am. Hist. Rev. PD DEC PY 2012 VL 117 IS 5 BP 1629 EP 1630 PG 3 WC History SC History GA 097JU UT WOS:000315470600110 ER PT J AU Balazik, MT Reine, KJ Spells, AJ Fredrickson, CA Fine, ML Garman, GC McIninch, SP AF Balazik, Matthew T. Reine, Kevin J. Spells, Albert J. Fredrickson, Charles A. Fine, Michael L. Garman, Greg C. McIninch, Stephen P. TI The Potential for Vessel Interactions with Adult Atlantic Sturgeon in the James River, Virginia SO NORTH AMERICAN JOURNAL OF FISHERIES MANAGEMENT LA English DT Article ID ACIPENSER-OXYRINCHUS; NORTH-AMERICA; MANAGEMENT; MORTALITY AB In 2012, all populations of Atlantic sturgeon Acipenser oxyrinchus oxyrinchus were listed as either threatened or endangered under the U.S. Endangered Species Act. During 20072010, researchers documented 31 carcasses of adult Atlantic sturgeon in the tidal freshwater portion of the James River, Virginia. Twenty-six of the carcasses had gashes from vessel propellers, and the remaining five carcasses were too decomposed to allow determination of the cause of death. The types of vessels responsible for these mortalities were not explicitly demonstrated. Most (84%) of the carcasses were found in a relatively narrow reach that was modified to increase shipping efficiency. To explore the number of Atlantic sturgeon being hit and their horizontal and depth distributions in relation to vessel draft, we conducted telemetry experiments on three living fish (all males) and six dead specimens. While staging (holding in an area from hours to days, with minimal upstream or downstream movements), the adult male Atlantic sturgeon spent most (62%) of the time within 1m of the river bottom. Assuming that behavior is not modified by vessel noise, adult male Atlantic sturgeon in the James River would rarely encounter small recreational boats or tugboats with shallow drafts; instead, mortalities are likely caused by deep-draft ocean cargo ships, which have drafts that coincide with the distribution of the tracked adult males. Dead specimens (n = 6) drifted with the current for several hours to almost 4 d before beaching at distances ranging from 0.5 to over 50 river kilometers from the point of release. We estimated that current monitoring in the James River documents less than one-third of vessel strike mortalities. A better understanding of Atlantic sturgeon behavior in the presence of vessels will aid in restoring this federally endangered species. Received February 20, 2012; accepted July 19, 2012 C1 [Balazik, Matthew T.; Garman, Greg C.; McIninch, Stephen P.] Virginia Commonwealth Univ, Ctr Environm Studies, Richmond, VA 23284 USA. [Reine, Kevin J.] USA, Corps Engineers, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. [Spells, Albert J.] US Fish & Wildlife Serv, Virginia Fisheries Coordinator Off, Charles City, VA 23030 USA. [Fredrickson, Charles A.] James River Assoc, Richmond, VA 23219 USA. [Fine, Michael L.] Virginia Commonwealth Univ, Dept Biol, Richmond, VA 23284 USA. RP Balazik, MT (reprint author), Virginia Commonwealth Univ, Ctr Environm Studies, 1000 West Cary St, Richmond, VA 23284 USA. EM balazikmt@vcu.edu FU Professional Association of Diving Instructors Foundation FX We thank Douglas Clarke and Charles Dickerson (USACE Engineer Research and Development Center); Peter Sturke, Brianna Langford, and David Hopler (VCU); and Christian Hager (Virginia Sea Grant) for their assistance with data development. We are also grateful to William Shuart and Jennifer Ciminelli (VCU) for GIS assistance; Eric Hilton (Virginia Institute of Marine Science), George Trice (commercial fisher), and Kelly Place (commercial fisher) for providing Atlantic sturgeon carcasses; and Tom Garin (Advanced Telemetry Systems) for donating radio tags. We appreciate Sarah Cameron (USACE Norfolk District) for supplying boat draft information and Jed Brown (U.S. Virgin Islands Division of Fish and Wildlife, St. Croix) and Matthew Fisher (Delaware DNREC, Division of Fish and Wildlife) for providing information on Delaware River Atlantic sturgeon vessel strikes. We thank the Professional Association of Diving Instructors Foundation for partial financial support. This is Contribution Number 25 of the VCU Rice Center. NR 17 TC 8 Z9 8 U1 2 U2 23 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA SN 0275-5947 J9 N AM J FISH MANAGE JI North Am. J. Fish Manage. PD DEC 1 PY 2012 VL 32 IS 6 BP 1062 EP 1069 DI 10.1080/02755947.2012.716016 PG 8 WC Fisheries SC Fisheries GA 097PB UT WOS:000315484900004 ER PT J AU Helfstein, S AF Helfstein, Scott TI Liabilities of Globalization: Sovereign Debt, International Investors and Interstate Conflict with Other People's Money SO INTERNATIONAL FINANCE LA English DT Article ID ECONOMIC INTERDEPENDENCE; PEACE; WAR; INTERESTS; BALANCE; CRISES; POWER AB Foreign ownership of government debt has increased steadily over the past 30 years with the globalization of financial markets. The increased availability of foreign borrowing may make it easier for countries to pursue bellicose policies by altering the costbenefit calculations associated with international conflict, giving rise to an underappreciated link between globalization and military action. This has not been addressed because globalization is most often approached through the income statement, such as trade flows, or the asset side of the balance sheet, such as foreign direct investment. A series of empirical tests using time-series cross-section analysis of militarized disputes, finds a strong relationship between foreign debt ownership and conflict. C1 US Mil Acad, Dept Social Sci, West Point, NY 10996 USA. RP Helfstein, S (reprint author), US Mil Acad, Dept Social Sci, West Point, NY 10996 USA. EM scott.helfstein@gmail.com NR 39 TC 0 Z9 0 U1 0 U2 9 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1367-0271 J9 INT FINANC JI Int. Financ. PD WIN PY 2012 VL 15 IS 3 BP 277 EP 288 DI 10.1111/j.1468-2362.2013.12004.x PG 12 WC Business, Finance; Economics SC Business & Economics GA 097QH UT WOS:000315488100001 ER PT J AU Allison, PG Moser, RD Weiss, CA Malone, PG Morefield, SW AF Allison, P. G. Moser, R. D. Weiss, C. A., Jr. Malone, P. G. Morefield, S. W. TI Nanomechanical and chemical characterization of the interface between concrete, glass-ceramic bonding enamel and reinforcing steel SO CONSTRUCTION AND BUILDING MATERIALS LA English DT Article DE Enamel coating; Bond strength; Nanoindentation; Corrosion; SEM; Concrete ID CORROSION-RESISTANCE; TRANSITION ZONE; STRENGTH; MORTAR; REBAR AB A glass-ceramic coating made by fusing dicalcium silicate and tricalcium silicate to the surface of glass-enameled steel has been successfully used to increase the bond between reinforcing steel and concrete and provide corrosion protection for the steel. A very strong interface that consists of hydrated cement and enameled glass over the top of a second strong interface between the enameled glass and the surface of the steel results from the outer layer of water-reactive silicates hydrating on contact with fresh concrete. Currently the mechanical characteristics (hardness, elastic modulus and strain-rate sensitivity), micromorphology, and the variation in interface chemical composition are being examined. Preliminary results indicate that the more gradual transition between the mechanical properties of the steel and the paste combined with improved integration between the coating and cement hydration products in the paste results in the increased bond strength observed in macroscale tests. Results from this study to characterize the developed coating are being used to engineer new optimized enamels for this unique application. Published by Elsevier Ltd. C1 [Allison, P. G.; Moser, R. D.; Weiss, C. A., Jr.; Malone, P. G.] USA, Engineer Res & Dev Ctr, Geotech & Struct Lab, Vicksburg, MS USA. [Morefield, S. W.] USA, Construct Engn Res Lab, Engineer Res & Dev Ctr, Champaign, IL 61824 USA. RP Allison, PG (reprint author), USA, Engineer Res & Dev Ctr, Geotech & Struct Lab, Vicksburg, MS USA. EM paul.g.allison@usace.army.mil OI Allison, Paul/0000-0002-9041-237X NR 19 TC 7 Z9 7 U1 1 U2 31 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0950-0618 J9 CONSTR BUILD MATER JI Constr. Build. Mater. PD DEC PY 2012 VL 37 BP 638 EP 644 DI 10.1016/j.conbuildmat.2012.07.066 PG 7 WC Construction & Building Technology; Engineering, Civil; Materials Science, Multidisciplinary SC Construction & Building Technology; Engineering; Materials Science GA 083AF UT WOS:000314434400073 ER PT J AU France, J AF France, John TI WALES AND THE CRUSADES c. 1095-1291 SO WELSH HISTORY REVIEW LA English DT Book Review C1 [France, John] US Mil Acad, West Point, NY USA. RP France, J (reprint author), US Mil Acad, West Point, NY USA. NR 1 TC 0 Z9 0 U1 0 U2 1 PU UNIV WALES PRESS PI CARDIFF PA 10 COLUMBUS WALK, BRIGANTINE PLACE, CARDIFF CF10 4UP, WALES SN 0043-2431 J9 WELSH HIST REV JI Welsh Hist. Rev. PD DEC PY 2012 VL 26 IS 2 BP 304 EP 305 PG 2 WC History SC History GA 085MU UT WOS:000314619700009 ER PT J AU DeCuir, EA Meissner, GP Wijewarnasuriya, PS Gautam, N Krishna, S Dhar, NK Welser, RE Sood, AK AF DeCuir, Eric A., Jr. Meissner, Gregory P. Wijewarnasuriya, Priyalal S. Gautam, Nutan Krishna, Sanjay Dhar, Nibir K. Welser, Roger E. Sood, Ashok K. TI Long-wave type-II superlattice detectors with unipolar electron and hole barriers SO OPTICAL ENGINEERING LA English DT Article DE type-II; InAs/GaSb; strained-layer superlattice; superlattices; pBiBn; infrared; dark current; photodetectors AB The performance of a long-wave infrared type-II InAs/GaSb superlattice photodetector with a 50% cut-off wavelength of approximately 8.7 mu m is presented. The ability to lower dark current densities over traditional P-type-Intrinsic-N-type diodes is offered by way of hetero-structure engineering of a pBiBn structure utilizing superlattice p-type (p) and n-type (n) contacts, an intrinsic (i) superlattice active (absorber) region, and unipolar superlattice electron and hole blocking (B) layers. The spectral response of this pBiBn detector structure was determined using a Fourier transform infrared spectrometer, and the quantum efficiency was determined using a 6250 nm narrow band filter and a 500 K blackbody source. A diode structure designed, grown, and fabricated in this study yielded a dark current density of 1.05 x 10(-5) A/cm(2) at a reverse bias of -50 mV and a specific detectivity value of greater than 10(11) Jones at 77 K. Theoretical fittings of the diode dark currents at 77 K were used in this study to help isolate the contributing current components observed in the empirical dark current data. A variable temperature study (80 to 300 K) of the dark current is presented for a diode demonstrating diffusion-limited dark current down to 77 K. (C) 2012 Society of Photo-Optical Instrumentation Engineers (SPIE). [DOI: 10.1117/1.OE.51.12.124001] C1 [DeCuir, Eric A., Jr.; Meissner, Gregory P.; Wijewarnasuriya, Priyalal S.] USA, Res Lab, Adelphi, MD 20783 USA. [Gautam, Nutan; Krishna, Sanjay] Univ New Mexico, Dept Elect & Comp Engn, Ctr High Technol Mat, Albuquerque, NM 87106 USA. [Dhar, Nibir K.] Def Adv Res Projects Agcy, Microsyst Technol Off, Arlington, VA 22203 USA. [Welser, Roger E.; Sood, Ashok K.] Magnolia Opt Technol Inc, Woburn, MA 01801 USA. RP DeCuir, EA (reprint author), USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM eric.a.decuir.civ@mail.mil NR 17 TC 5 Z9 6 U1 1 U2 20 PU SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98225 USA SN 0091-3286 J9 OPT ENG JI Opt. Eng. PD DEC PY 2012 VL 51 IS 12 AR 124001 DI 10.1117/1.OE.51.12.124001 PG 8 WC Optics SC Optics GA 083KV UT WOS:000314463400026 ER PT J AU Acevedo, JL Shah, RK Brietzke, SE AF Acevedo, Jason L. Shah, Rahul K. Brietzke, Scott E. TI In Response to "Re: 'Systematic Review of Complications of Tonsillotomy versus Tonsillectomy'" from Walton et al. SO OTOLARYNGOLOGY-HEAD AND NECK SURGERY LA English DT Letter C1 [Acevedo, Jason L.] Uniformed Serv Univ Hlth Sci, Reynolds Army Community Hosp, Hlth Sci Ctr, Ft Sill, OK USA. [Shah, Rahul K.] George Washington Univ, Childrens Natl Med Ctr, Sch Med, Washington, DC USA. [Brietzke, Scott E.] Uniformed Serv Univ Hlth Sci, Walter Reed Natl Mil Med Ctr, Bethesda, MD 20814 USA. RP Acevedo, JL (reprint author), Uniformed Serv Univ Hlth Sci, Reynolds Army Community Hosp, Hlth Sci Ctr, Ft Sill, OK USA. EM jasag00@yahoo.com NR 2 TC 0 Z9 0 U1 0 U2 3 PU SAGE PUBLICATIONS LTD PI LONDON PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND SN 0194-5998 J9 OTOLARYNG HEAD NECK JI Otolaryngol. Head Neck Surg. PD DEC PY 2012 VL 147 IS 6 BP 1164 EP 1165 DI 10.1177/0194599812463552 PG 2 WC Otorhinolaryngology; Surgery SC Otorhinolaryngology; Surgery GA 081CH UT WOS:000314293000033 ER PT J AU O'Connell, RJ Kim, JH Corey, L Michael, NL AF O'Connell, Robert J. Kim, Jerome H. Corey, Lawrence Michael, Nelson L. TI Human Immunodeficiency Virus Vaccine Trials SO COLD SPRING HARBOR PERSPECTIVES IN MEDICINE LA English DT Article ID T-CELL RESPONSES; RECOMBINANT GLYCOPROTEIN-120 VACCINE; NEUTRALIZING MONOCLONAL-ANTIBODIES; PREVENT HIV-1 INFECTION; DNA CANDIDATE VACCINE; ADENOVIRUS SEROTYPE 5; I CLINICAL-TRIAL; IMMUNE-RESPONSES; PHASE-I; IMMUNOGENICITY EVALUATION AB More than 2 million AIDS-related deaths occurred globally in 2008, and more than 33 million people are living with HIV/AIDS. Despite promising advances in prevention, an estimated 2.7 million new HIV infections occurred in that year, so that for every two patients placed on combination antiretroviral treatment, five people became infected. The pandemic poses a formidable challenge to the development, progress, and stability of global society 30 years after it was recognized. Experimental preventive HIV-1 vaccines have been administered to more than 44,000 human volunteers in more than 187 separate trials since 1987. Only five candidate vaccine strategies have been advanced to efficacy testing. The recombinant glycoprotein (rgp) 120 subunit vaccines, AIDSVAX B/B and AIDSVAX B/E, and the Merck Adenovirus serotype (Ad) 5 viral-vector expressing HIV-1 Gag, Pol, and Nef failed to show a reduction in infection rate or lowering of postinfection viral set point. Most recently, a phase III trial that tested a heterologous prime-boost vaccine combination of ALVAC-HIV vCP1521 and bivalent rgp120 (AIDSVAX B/E) showed 31% efficacy in protection from infection among community-risk Thai participants. A fifth efficacy trial testing a DNA/recombinant(r) Ad5 prime-boost combination is currently under way. We review the clinical trials of HIV vaccines that have provided insight into human immunogenicity or efficacy in preventing HIV-1 infection. C1 [O'Connell, Robert J.; Kim, Jerome H.; Michael, Nelson L.] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD 20910 USA. [Corey, Lawrence] Fred Hutchinson Canc Res Ctr, Seattle, WA 98109 USA. RP Michael, NL (reprint author), Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD 20910 USA. EM nmichael@hivresearch.org NR 182 TC 28 Z9 29 U1 0 U2 25 PU COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT PI COLD SPRING HARBOR PA 1 BUNGTOWN RD, COLD SPRING HARBOR, NY 11724 USA SN 2157-1422 J9 CSH PERSPECT MED JI Cold Spring Harb. Perspect. Med. PD DEC PY 2012 VL 2 IS 12 AR a007351 DI 10.1101/cshperspect.a007351 PG 21 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA 080ZD UT WOS:000314282700001 PM 23209178 ER PT J AU Zumbrun, EE Abdeltawab, NF Bloomfield, HA Chance, TB Nichols, DK Harrison, PE Kotb, M Nalca, A AF Zumbrun, Elizabeth E. Abdeltawab, Nourtan F. Bloomfield, Holly A. Chance, Taylor B. Nichols, Donald K. Harrison, Paige E. Kotb, Malak Nalca, Aysegul TI Development of a Murine Model for Aerosolized Ebolavirus Infection Using a Panel of Recombinant Inbred Mice SO VIRUSES-BASEL LA English DT Article DE Ebola; ebolavirus; filovirus; aerosol; mouse; BXD; recombinant inbred ID VIRUS-INFECTION; HEMORRHAGIC-FEVER; MOUSE MODEL; CYNOMOLGUS MACAQUES; INTERFERON; RESISTANCE; SUSCEPTIBILITY; PATHOGENESIS; PROPHYLAXIS; ACTIVATION AB Countering aerosolized filovirus infection is a major priority of biodefense research. Aerosol models of filovirus infection have been developed in knock-out mice, guinea pigs and non-human primates; however, filovirus infection of immunocompetent mice by the aerosol route has not been reported. A murine model of aerosolized filovirus infection in mice should be useful for screening vaccine candidates and therapies. In this study, various strains of wild-type and immunocompromised mice were exposed to aerosolized wild-type (WT) or mouse-adapted (MA) Ebola virus (EBOV). Upon exposure to aerosolized WT-EBOV, BALB/c, C57BL/6 (B6), and DBA/2 (D2) mice were unaffected, but 100% of severe combined immunodeficiency (SCID) and 90% of signal transducers and activators of transcription (Stat1) knock-out (KO) mice became moribund between 7-9 days post-exposure (dpe). Exposure to MA-EBOV caused 15% body weight loss in BALB/c, but all mice recovered. In contrast, 10-30% lethality was observed in B6 and D2 mice exposed to aerosolized MA-EBOV, and 100% of SCID, Stat1 KO, interferon (IFN)-gamma KO and Perforin KO mice became moribund between 7-14 dpe. In order to identify wild-type, inbred, mouse strains in which exposure to aerosolized MA-EBOV is uniformly lethal, 60 BXD (C57BL/6 crossed with DBA/2) recombinant inbred (RI) and advanced RI (ARI) mouse strains were exposed to aerosolized MA-EBOV, and monitored for disease severity. A complete spectrum of disease severity was observed. All BXD strains lost weight but many recovered. However, infection was uniformly lethal within 7 to 12 days post-exposure in five BXD strains. Aerosol exposure of these five BXD strains to 10-fold less MA-EBOV resulted in lethality ranging from 0% in two strains to 90-100% lethality in two strains. Analysis of post-mortem tissue from BXD strains that became moribund and were euthanized at the lower dose of MA-EBOV, showed liver damage in all mice as well as lung lesions in two of the three strains. The two BXD strains that exhibited 90-100% mortality, even at a low dose of airborne MA-EBOV will be useful mouse models for testing vaccines and therapies. Additionally, since disease susceptibility is affected by complex genetic traits, a systems genetics approach was used to identify preliminary gene loci modulating disease severity among the panel BXD strains. Preliminary quantitative trait loci (QTLs) were identified that are likely to harbor genes involved in modulating differential susceptibility to Ebola infection. C1 [Zumbrun, Elizabeth E.; Bloomfield, Holly A.; Harrison, Paige E.; Nalca, Aysegul] USA, Ctr Aerobiol Sci, Med Res Inst Infect Dis USAMRIID, Ft Detrick, MD 21702 USA. [Abdeltawab, Nourtan F.; Kotb, Malak] Univ Cincinnati, Dept Mol Genet Biochem & Mol Biol, Cincinnati, OH 45267 USA. [Chance, Taylor B.; Nichols, Donald K.] USA, Div Pathol, Med Res Inst Infect Dis USAMRIID, Ft Detrick, MD 21702 USA. RP Zumbrun, EE (reprint author), USA, Ctr Aerobiol Sci, Med Res Inst Infect Dis USAMRIID, 1425 Porter St, Ft Detrick, MD 21702 USA. EM Elizabeth.Zumbrun@us.army.mil; nourtan@gmail.com; Holly.A.Bloomfield@us.army.mil; Taylor.Chance@us.army.mil; Donald.K.Nichols@us.army.mil; paigeha@pcom.edu; Malak.Kotb@uc.edu; Aysegul.Nalca@us.army.mil RI Abdeltawab, Nourtan/J-1976-2012; OI Abdeltawab, Nourtan/0000-0002-1290-2197; Zumbrun, Elizabeth/0000-0002-9897-7201 FU Office of Biodefense Research Affairs (OBRA/NIAID) [A120-B.20]; Medical Research Service, Department of Veterans Affairs, Merit Award FX The authors gratefully acknowledge the contributions of USAMRIIDs Center for Aerobiological Sciences personnel, the Genomic Center, Diagnositic Systems Division, Pathology Division, Veterinary Medicine Division and Deborah Harrison for their help with this study. We would also like to thank Susan Garges and Judy Hewitt from The National Institute of Allergy and Infectious Diseases (NIAID) for their support of this study. The research described herein was sponsored by the Office of Biodefense Research Affairs (OBRA/NIAID with interagency agreement A120-B.20 between USAMRIID and NIAID. Malak Kotb is supported by the Medical Research Service, Department of Veterans Affairs, Merit Award. NR 36 TC 14 Z9 14 U1 0 U2 13 PU MDPI AG PI BASEL PA POSTFACH, CH-4005 BASEL, SWITZERLAND SN 1999-4915 J9 VIRUSES-BASEL JI Viruses-Basel PD DEC PY 2012 VL 4 IS 12 BP 3468 EP 3493 DI 10.3390/v4123468 PG 26 WC Virology SC Virology GA 082OO UT WOS:000314401700011 PM 23207275 ER PT J AU Shurtleff, AC Biggins, JE Keeney, AE Zumbrun, EE Bloomfield, HA Kuehne, A Audet, JL Alfson, KJ Griffiths, A Olinger, GG Bavari, S AF Shurtleff, Amy C. Biggins, Julia E. Keeney, Ashley E. Zumbrun, Elizabeth E. Bloomfield, Holly A. Kuehne, Ana Audet, Jennifer L. Alfson, Kendra J. Griffiths, Anthony Olinger, Gene G. Bavari, Sina CA Grp FANG Assay Working Grp TI Standardization of the Filovirus Plaque Assay for Use in Preclinical Studies SO VIRUSES-BASEL LA English DT Article DE plaque assay; filovirus; Ebola; ebolavirus; marburgvirus; Marburg virus; Vero ID EBOLA-VIRUS; POSTEXPOSURE PROTECTION; NONHUMAN-PRIMATES; MARBURG VIRUSES; GUINEA-PIGS; CHALLENGE AB The filovirus plaque assay serves as the assay of choice to measure infectious virus in a cell culture, blood, or homogenized tissue sample. It has been in use for more than 30 years and is the generally accepted assay used to titrate virus in samples from animals treated with a potential antiviral therapeutic or vaccine. As these animal studies are required for the development of vaccines and therapeutics under the FDA Animal Rule, it is essential to have a standardized assay to compare their efficacies against the various filoviruses. Here, we present an evaluation of the conditions under which the filovirus plaque assay performs best for the Ebola virus Kikwit variant and the Angola variant of Marburg virus. The indicator cell type and source, inoculum volumes, length of incubation and general features of filovirus biology as visualized in the assay are addressed in terms of the impact on the sample viral titer calculations. These optimization studies have resulted in a plaque assay protocol which can be used for preclinical studies, and as a standardized protocol for use across institutions, to aid in data comparison. This protocol will be validated for use in GLP studies supporting advanced development of filovirus therapeutics and vaccines. C1 [Shurtleff, Amy C.; Bavari, Sina] USA, Integrated Toxicol Div, Med Res Inst Infect Dis, Frederick, MD 21702 USA. [Biggins, Julia E.; Keeney, Ashley E.; Kuehne, Ana; Audet, Jennifer L.; Olinger, Gene G.] USA, Div Virol, Med Res Inst Infect Dis, Frederick, MD 21702 USA. [Zumbrun, Elizabeth E.; Bloomfield, Holly A.] USA, Ctr Aerobiol Studies, Med Res Inst Infect Dis, Frederick, MD 21702 USA. [Alfson, Kendra J.; Griffiths, Anthony] Texas Biomed Res Inst, Dept Virol & Immunol, San Antonio, TX 78227 USA. RP Bavari, S (reprint author), USA, Integrated Toxicol Div, Med Res Inst Infect Dis, 1425 Porter St, Frederick, MD 21702 USA. EM amy.c.shurtleff.ctr@us.army.mil; julia.biggins@us.army.mil; ashley.keeney@us.army.mil; elizabeth.zumbrun@us.army.mil; holly.a.bloomfield@us.army.mil; ana.kuehne@us.army.mil; jennifer.l.audet@us.army.mil; kalfson@txbiomed.org; agriffiths@txbiomed.org; gene.olinger@us.army.mil; sina.bavari@us.army.mil OI Alfson, Kendra/0000-0001-6031-5360; Olinger, Gene/0000-0001-7338-0292; Zumbrun, Elizabeth/0000-0002-9897-7201 FU CBMS/JVAP, under the Joint Program Executive Office for Chemical and Biological Defense FX The authors would like to thank Sarah Norris, Biostatistician, for her expert guidance in analyzing datasets, and Dennis Taylor for project management and coordination support. The authors would like to express deep gratitude to Nicole Kilgore of Chemical Biological Medical Systems Joint Vaccine Acquisition Program (CBMS/JVAP) for support and guidance in developing an approach to optimize the plaque assay protocol for future standardization for use between institutions conducting filovirus assessments of priority to the Filovirus Animal Nonclinical Group. This work was funded in part by CBMS/JVAP, under the Joint Program Executive Office for Chemical and Biological Defense. NR 22 TC 13 Z9 14 U1 0 U2 9 PU MDPI AG PI BASEL PA POSTFACH, CH-4005 BASEL, SWITZERLAND SN 1999-4915 J9 VIRUSES-BASEL JI Viruses-Basel PD DEC PY 2012 VL 4 IS 12 BP 3511 EP 3530 DI 10.3390/v4123511 PG 20 WC Virology SC Virology GA 082OO UT WOS:000314401700013 PM 23223188 ER PT J AU Shurtleff, AC Garza, N Lackemeyer, M Carrion, R Griffiths, A Patterson, J Edwin, SS Bavari, S AF Shurtleff, Amy C. Garza, Nicole Lackemeyer, Matthew Carrion, Ricardo, Jr. Griffiths, Anthony Patterson, Jean Edwin, Samuel S. Bavari, Sina TI The Impact of Regulations, Safety Considerations and Physical Limitations on Research Progress at Maximum Biocontainment SO VIRUSES-BASEL LA English DT Review DE biocontainment; biosafety level 4 (BSL-4); biological select agents and toxins (BSAT); positive pressure suit; biodefense; biosecurity; ebola virus; highly pathogenic viruses; limitations; collaboration ID LABORATORY WORKERS; VIRUS; INACTIVATION; BIOSURETY; TISSUES AB We describe herein, limitations on research at biosafety level 4 (BSL-4) containment laboratories, with regard to biosecurity regulations, safety considerations, research space limitations, and physical constraints in executing experimental procedures. These limitations can severely impact the number of collaborations and size of research projects investigating microbial pathogens of biodefense concern. Acquisition, use, storage, and transfer of biological select agents and toxins (BSAT) are highly regulated due to their potential to pose a severe threat to public health and safety. All federal, state, city, and local regulations must be followed to obtain and maintain registration for the institution to conduct research involving BSAT. These include initial screening and continuous monitoring of personnel, controlled access to containment laboratories, accurate and current BSAT inventory records. Safety considerations are paramount in BSL-4 containment laboratories while considering the types of research tools, workflow and time required for conducting both in vivo and in vitro experiments in limited space. Required use of a positive-pressure encapsulating suit imposes tremendous physical limitations on the researcher. Successful mitigation of these constraints requires additional time, effort, good communication, and creative solutions. Test and evaluation of novel vaccines and therapeutics conducted under good laboratory practice (GLP) conditions for FDA approval are prioritized and frequently share the same physical space with important ongoing basic research studies. The possibilities and limitations of biomedical research involving microbial pathogens of biodefense concern in BSL-4 containment laboratories are explored in this review. C1 [Shurtleff, Amy C.; Garza, Nicole; Bavari, Sina] USA, Integrated Toxicol Div, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. [Lackemeyer, Matthew] Natl Inst Allergy & Immunol, Integrated Res Facil Frederick, Div Clin Res, NIH, Ft Detrick, MD 21702 USA. [Carrion, Ricardo, Jr.; Griffiths, Anthony; Patterson, Jean] Texas Biomed Res Inst, Dept Virol & Immunol, San Antonio, TX 78245 USA. [Edwin, Samuel S.] USA, Select Agent Management Div, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. RP Bavari, S (reprint author), USA, Integrated Toxicol Div, Med Res Inst Infect Dis, 1425 Porter St, Ft Detrick, MD 21702 USA. EM amy.c.shurtleff.ctr@us.army.mil; nicole.garza@us.army.mil; matthew.lackemeyer@nih.gov; carrion@txbiomed.org; agriffiths@txbiomed.org; jpatters@txbiomed.org; samuel.edwin@us.army.mil; sina.bavari@us.army.mil NR 17 TC 6 Z9 6 U1 1 U2 18 PU MDPI AG PI BASEL PA POSTFACH, CH-4005 BASEL, SWITZERLAND SN 1999-4915 J9 VIRUSES-BASEL JI Viruses-Basel PD DEC PY 2012 VL 4 IS 12 BP 3932 EP 3951 DI 10.3390/v4123932 PG 20 WC Virology SC Virology GA 082OO UT WOS:000314401700033 PM 23342380 ER PT J AU Murgia, MV Rauf, A Tang, Y Gingerich, E Lee, CW Saif, YM AF Murgia, M. V. Rauf, A. Tang, Y. Gingerich, E. Lee, C. -W. Saif, Y. M. TI Prevalence of Parvoviruses in Commercial Turkey Flocks SO AVIAN DISEASES LA English DT Article DE turkey; parvovirus; prevalence ID CHICKEN; GENOME; INFECTION AB Turkey parvovirus belongs to the family Parvoviridae, subfamily Parvovirinae, Genus parvovirus. Since the initial report on turkey parvovirus in the United States appeared in 1983, there had been no further reports of parvovirus in turkeys until 2008. The aims of our study were to determine the prevalence of parvovirus in commercial turkey flocks using PCR; to determine their genetic relationship to previous strains identified in North America and Europe; and to test samples for enteric viruses by transmission electron microscopy (TEM). A total of 169 fecal samples collected from 42 turkey farms in four different states within the United States between 2000 and 2010 were examined. We found that the most frequently detected viruses by TEM were small round viruses, accounting for 52% of the examined samples; however, the PCR detected parvoviruses in 71% of the samples. The phylogenetic analysis of partial nonstructural gene sequences showed a certain degree of variability among the turkey samples tested in the study. Moreover, there was a clear dichotomy in the phylogenetic tree between chicken and turkey samples, with the exception of one turkey isolate from 2000, which clustered together with the chicken group. C1 [Murgia, M. V.; Rauf, A.; Lee, C. -W.; Saif, Y. M.] Ohio State Univ, Food Anim Hlth Res Program, Ohio Agr Res & Dev Ctr, Wooster, OH 44691 USA. [Tang, Y.] Walter Reed Army Inst Res, Div Viral Dis, Dept Mol Studies, Silver Spring, MD 20910 USA. [Gingerich, E.] Diamond V, Tech Serv, Cedar Rapids, IA 52407 USA. RP Saif, YM (reprint author), Ohio State Univ, Food Anim Hlth Res Program, Ohio Agr Res & Dev Ctr, 1680 Madison Ave, Wooster, OH 44691 USA. EM saif.1@osu.edu FU Ohio Agricultural Research and Development Center, The Ohio State University FX We would like to thank the Molecular and Cellular Imaging Center, OARDC/OSU, and in particular Dr. T. Meulia, A. Kaszas, and J. Whittier. Salaries and research support were provided by state and federal funds appropriated to the Ohio Agricultural Research and Development Center, The Ohio State University. NR 19 TC 4 Z9 4 U1 0 U2 3 PU AMER ASSOC AVIAN PATHOLOGISTS PI ATHENS PA 953 COLLEGE STATION RD, ATHENS, GA 30602-4875 USA SN 0005-2086 J9 AVIAN DIS JI Avian Dis. PD DEC PY 2012 VL 56 IS 4 BP 744 EP 749 PG 6 WC Veterinary Sciences SC Veterinary Sciences GA 065GF UT WOS:000313135800017 PM 23397849 ER PT J AU Margolis, LM Pasiakos, SM Karl, JP Rood, JC Cable, SJ Williams, KW Young, AJ McClung, JP AF Margolis, Lee M. Pasiakos, Stefan M. Karl, J. Philip Rood, Jennifer C. Cable, Sonya J. Williams, Kelly W. Young, Andrew J. McClung, James P. TI Differential Effects of Military Training on Fat-Free Mass and Plasma Amino Acid Adaptations in Men and Women SO NUTRIENTS LA English DT Article DE skeletal muscle; essential amino acids; branched-chain amino acids; exercise training; military training; adaptation ID MUSCLE PROTEIN-SYNTHESIS; PREDICTING BODY DENSITY; SKELETAL-MUSCLE; GENERALIZED EQUATIONS; ENDURANCE EXERCISE; GENDER-DIFFERENCES; PHYSICAL-FITNESS; US ARMY; METABOLISM; RESTRICTION AB Fat-free mass (FFM) adaptations to physical training may differ between sexes based on disparities in fitness level, dietary intake, and levels of plasma amino acids (AA). This investigation aimed to determine FFM and plasma AA responses to military training, examine whether adaptations differ between male and female recruits, and explore potential associations between FFM and AA responses to training. Body composition and plasma AA levels were assessed in US Army recruits (n = 209, 118 males, 91 females) before (baseline) and every three weeks during basic combat training (BCT), a 10-week military training course. Body weight decreased in men but remained stable in women during BCT (sex-by-time interaction, P < 0.05). Fifty-eight percent of recruits gained FFM during BCT, with more (P < 0.05) females (88%) gaining FFM than males (36%). Total plasma AA increased (P < 0.05) during BCT, with greater (P < 0.05) increases observed in females (17%) then in males (4%). Essential amino acids (EAA) and branched-chain amino acids (BCAA) were increased (P < 0.05) in females but did not change in males (sex-by-time interaction, P < 0.05). Independent of sex, changes in EAA (r = 0.34) and BCAA (r = 0.27) from baseline were associated with changes in FFM (P < 0.05); greater (P < 0.05) increases in AA concentrations were observed for those who gained FFM. Increases in FFM and plasma AA suggest that BCT elicits a more pronounced anabolic response in women compared to men, which may reflect sex-specific differences in the relative intensity of the combined training and physiological stimulus associated with BCT. C1 [Margolis, Lee M.; Pasiakos, Stefan M.; Karl, J. Philip; Young, Andrew J.; McClung, James P.] USA, Mil Nutr Div, Environm Med Res Inst, Natick, MA 01760 USA. [Rood, Jennifer C.] Louisiana State Univ Syst, Pennington Biomed Res Ctr, Baton Rouge, LA 70808 USA. [Cable, Sonya J.; Williams, Kelly W.] Directorate Basic Combat Training, Ft Jackson, SC 29207 USA. RP McClung, JP (reprint author), USA, Mil Nutr Div, Environm Med Res Inst, 15 Kansas St, Natick, MA 01760 USA. EM lee.margolis@us.army.mil; stefan.pasiakos@us.army.mil; james.p.karl@us.army.mil; jennifer.rood@pbrc.edu; sonya.cable@us.army.mil; kelly.wells.williams@gmail.com; andrew.j.young@us.army.mil; james.mcclung3@us.army.mil RI McClung, James/A-1989-2009; Pasiakos, Stefan/E-6295-2014; OI Pasiakos, Stefan/0000-0002-5378-5820; Karl, J. Philip/0000-0002-5871-2241; , Lee/0000-0002-0652-1304 NR 34 TC 5 Z9 5 U1 2 U2 12 PU MDPI AG PI BASEL PA POSTFACH, CH-4005 BASEL, SWITZERLAND SN 2072-6643 J9 NUTRIENTS JI Nutrients PD DEC PY 2012 VL 4 IS 12 BP 2035 EP 2046 DI 10.3390/nu4122035 PG 12 WC Nutrition & Dietetics SC Nutrition & Dietetics GA 060KO UT WOS:000312776900014 PM 23250145 ER PT J AU Legler, PM Leary, DH Hervey, WJ Millard, CB AF Legler, Patricia M. Leary, Dagmar H. Hervey, William Judson Millard, Charles B. TI A role for His-160 in peroxide inhibition of S. cerevisiae S-formylglutathione hydrolase: Evidence for an oxidation sensitive motif SO ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS LA English DT Article DE Organophosphate; Sulfenic acid; Sulflnic acid; Sulfonic acid; Oxidation; Motif; Glutathione; Serine hydrolase; Carboxylesterase; Thioesterase ID CYSTEINE SULFENIC ACID; SACCHAROMYCES-CEREVISIAE; N-ETHYLMALEIMIDE; ALDEHYDE DEHYDROGENASE; BACILLUS-SUBTILIS; AMINO-ACIDS; ACTIVE-SITE; PROTEIN; PURIFICATION; ESTERASE AB While the general catalytic mechanism of the widespread serine hydrolase superfamily has been documented extensively, much less is known about its varied modes of functional modulation within biological systems. Under oxidizing conditions, inhibition of Saccharomyces cerevisiae S-formylglutathione hydrolase (SFGH, homologous to human esterase D) activity is attributable to a cysteine (Cys-60) adjacent to its catalytic triad and approximately 8.0 angstrom away from the O gamma of the nucleophilic serine. Cys-60 is oxidized to a sulfenic acid in the structure of the Paraoxon-inhibited W197I variant (PDB 3C6B). The structural snap-shot captured an unstable reversibly oxidized state, but it remained unclear as to whether the oxidation occurred before, during, or after the reaction with the organophosphate inhibitor. To determine if the oxidation of Cys-60 was functionally linked to ester hydrolysis, we used kinetic analysis and site-directed mutagenesis in combination with X-ray crystallography. The essential nature of Cys-60 for oxidation is demonstrated by the C6OS variant, which is not inhibited by peroxide in the presence or absence of substrate. In the presence of substrate, the rate of inhibition of the WT SFGH by peroxide increases 14-fold, suggesting uncompetitive behavior linking oxidation to ester hydrolysis. Here we found one variant, H160I, which is activated by peroxide. This variant is activated at comparable rates in the presence or absence of substrate, indicating that the conserved His-160 is involved in the inhibitory mechanism linking ester hydrolysis to the oxidation of Cys-60. Copper chloride inhibition experiments show that at least two metal ions bind and inhibit both WT and H160I. A structure of the Paraoxon-inhibited W197I variant soaked with CuCl2 shows density for one metal ion per monomer at the N-terminus, and density around the Cys-60 sulfur consistent with a sulfinic acid, Cys-SO2. A Dali structural similarity search uncovered two other enzymes (Bacillus subtilis RsbQ, 1WOM and Clostridium acetobutylicum Lipase esterase, 3E0X) that contain a similar Cys adjacent to a catalytic triad. We speculate that the regulatory motif uncovered is conserved in some D-type esterases and discuss its structural similarities in the active site of human protective protein (HPP; also known as Cathepsin A). Published by Elsevier Inc. C1 [Legler, Patricia M.; Leary, Dagmar H.; Hervey, William Judson] USN, Ctr Bio Mol Sci & Engn, Res Labs, Washington, DC 20375 USA. [Millard, Charles B.] USA, Med Res & Mat Command, Ft Detrick, MD 21702 USA. RP Legler, PM (reprint author), USN, Ctr Bio Mol Sci & Engn, Res Labs, 4555 Overlook Ave, Washington, DC 20375 USA. EM plegler2@gmail.com FU National Research Council Research Associates Program of the National Academies of Science; U.S. Defense Threat Reduction Agency JSTO award [1.D0015_06_WR_C, 1.D0006_08_WR_C] FX We thank Derrick J. Robinson and Benjamin V. Clingan for technical assistance. W.J.H. and D.H.L. gratefully acknowledges the support from the National Research Council Research Associates Program of the National Academies of Science. We thank Dr. Albert S. Mildvan for useful discussions and helpful suggestions.; This work was funded by the U.S. Defense Threat Reduction Agency JSTO award 1.D0015_06_WR_C (CBM) and 1.D0006_08_WR_C (C.B.M. and P.M.L.). The opinions or assertions contained herein belong to the authors and are not necessarily the official views of the U.S. Army, U.S. Navy, or the U.S. Department of Defense. NR 40 TC 4 Z9 4 U1 1 U2 5 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0003-9861 J9 ARCH BIOCHEM BIOPHYS JI Arch. Biochem. Biophys. PD DEC 1 PY 2012 VL 528 IS 1 BP 7 EP 20 DI 10.1016/j.abb.2012.08.001 PG 14 WC Biochemistry & Molecular Biology; Biophysics SC Biochemistry & Molecular Biology; Biophysics GA 068PZ UT WOS:000313380000002 PM 22906720 ER PT J AU Danabalan, R Ponsonby, DJ Linton, YM AF Danabalan, Renita Ponsonby, David J. Linton, Yvonne-Marie TI A CRITICAL ASSESSMENT OF AVAILABLE MOLECULAR IDENTIFICATION TOOLS FOR DETERMINING THE STATUS OF CULEX PIPIENS SL IN THE UNITED KINGDOM SO JOURNAL OF THE AMERICAN MOSQUITO CONTROL ASSOCIATION LA English DT Article DE Culex pipiens complex; Culex torrentium; identification; CQ11 assay; COI barcoding ID WEST-NILE-VIRUS; VALLEY FEVER VIRUS; DIPTERA-CULICIDAE; VECTOR COMPETENCE; MOSQUITOS; COMPLEX; DNA; TRANSMISSION; TORRENTIUM; UGANDA AB Until the relatively recent application of molecular identification tools, identification of Culex pipiens f. pipiens and Cx. pipiens f. molestus relied on expressed ecological characteristics, including autogeny, host preference and stenogamy. Herein we test two DNA assays, one based on the microsatellite locus CQ11 and the other on species-diagnostic nucleotide bases in the mtDNA cytochrome oxidase I, on 322 wild-caught Cx. pipiens s.l. collected in above ground habitats from 6 counties across southern England and Wales. Of the 322 Culex pipiens s.l. screened using the CQ11 assay, 205 were identified as Cx. pipiens f. pipiens, 95 as Cx. pipiens f. molestus and 22 were determined as hybrids. Neither above ground Cx. pipiens f. molestus, nor hybrids have previously been reported in UK. However, comparison of COI barcodes (658bp) from 30 individuals from the above defined grouping indicated that inadvertent inclusion of specimens of Cx. torrentium resulted in the expected product sizes purportedly diagnostic for Cx. pipiens f. molestus, Cx. pipiens f. pipiens and hybrids in the CQ11 assay. COI sequences showed Cx. torrentium was misidentified as Cx. pipiens s.l. in more than 50% of cases and that all above ground Cx. pipiens s.l. collected in this study were in fact Cx. pipiens f. pipiens. Thus in regions of the Palearctic where Cx. torrentium and Cx. pipiens s.l. are sympatric, we showed that the CQ11 assay produces misleading results and should not be used. C1 [Danabalan, Renita; Linton, Yvonne-Marie] Nat Hist Museum, London SW7 5BD, England. [Danabalan, Renita; Ponsonby, David J.] Canterbury Christ Church Univ, Canterbury, Kent, England. [Danabalan, Renita] Humboldt Univ, Museum Nat Kunde, Leibniz Inst Res Evolut & Biodivers, D-10099 Berlin, Germany. [Linton, Yvonne-Marie] Walter Reed Army Inst Res, Entomol Branch, Silver Spring, MD 20910 USA. RP Linton, YM (reprint author), Nat Hist Museum, Cromwell Rd, London SW7 5BD, England. FU Canterbury Christ Church University; Natural History Museum London; National Research Council FX This study formed part of the PhD thesis of RD, and was funded through a PhD studentship from Canterbury Christ Church University awarded to RD, DJP and YML. Field collections were funded by the Natural History Museum London (to YML). Field collections were carried out by RD and YML, with periodic assistance from Magdalena Zarowiecki and Michael Monaghan. This manuscript was prepared whilst YML held a National Research Council Research Associateship Award at the Walter Reed Army Institute of Research. The material to be published reflects the views of the authors and should not be construed to represent those of the US Department of the Army or the US Department of Defense. NR 36 TC 9 Z9 10 U1 4 U2 27 PU AMER MOSQUITO CONTROL ASSOC PI MOUNT LAUREL PA 15000 COMMERCE PARKWAY, SUITE C, MOUNT LAUREL, NJ 08054 USA SN 8756-971X J9 J AM MOSQUITO CONTR JI J. Am. Mosq. Control Assoc. PD DEC PY 2012 VL 28 IS 4 SU S BP 68 EP 74 PG 7 WC Entomology SC Entomology GA 059BN UT WOS:000312679500007 PM 23401945 ER PT J AU Thomas, AK Bonura, BM Taylor, HA Brunye, TT AF Thomas, Ayanna K. Bonura, Bailey M. Taylor, Holly A. Brunye, Tad T. TI Metacognitive Monitoring in Visuospatial Working Memory SO PSYCHOLOGY AND AGING LA English DT Article DE visuospatial working memory; older adults; metamemory ID ADULT AGE-DIFFERENCES; SPATIAL INFORMATION; OBJECT IDENTITY; OLDER-ADULTS; LOCATION; BINDING; SPAN; PERFORMANCE; JUDGMENTS; KNOWLEDGE AB Research within the domain of spatial working memory has not conclusively determined whether age differences exist. Under some conditions, age-equivalence has been demonstrated for location information. Under other conditions, age-equivalence has been demonstrated for identity information. In three experiments, we examined identity memory, location memory, and their combination in a visuospatial working memory (VSWM) paradigm. Older and younger adults were compared. In addition, we examined metacognitive processes associated with each VSWM component. Results suggest an overall age-deficit in VSWM. Our results also suggest that location information may be less effortfully processed as compared to identity information. With regarding to metacognitive monitoring, we found age-equivalence for identity prediction accuracy and an age-related deficit in prediction accuracy for location information. The present study is the first to demonstrate both age-deficits and age-equivalence in metacognitive prediction accuracy within a working memory paradigm. C1 [Thomas, Ayanna K.] Tufts Univ, Dept Psychol, Medford, MA 02155 USA. [Brunye, Tad T.] USA, NSRDEC, Natick, MA 01760 USA. RP Thomas, AK (reprint author), Tufts Univ, Dept Psychol, 490 Boston Ave, Medford, MA 02155 USA. EM ayanna.thomas@tufts.edu NR 57 TC 3 Z9 3 U1 2 U2 18 PU AMER PSYCHOLOGICAL ASSOC PI WASHINGTON PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA SN 0882-7974 J9 PSYCHOL AGING JI Psychol. Aging PD DEC PY 2012 VL 27 IS 4 BP 1099 EP 1110 DI 10.1037/a0028556 PG 12 WC Gerontology; Psychology, Developmental SC Geriatrics & Gerontology; Psychology GA 067PB UT WOS:000313306500035 PM 22663158 ER PT J AU Bruscino, T AF Bruscino, Thomas TI Enduring Battle: American Soldiers in Three Wars, 1776-1945 SO REVIEWS IN AMERICAN HISTORY LA English DT Book Review C1 [Bruscino, Thomas] USA, Sch Adv Mil Studies, Washington, DC 20310 USA. RP Bruscino, T (reprint author), USA, Sch Adv Mil Studies, Washington, DC 20310 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU JOHNS HOPKINS UNIV PRESS PI BALTIMORE PA JOURNALS PUBLISHING DIVISION, 2715 NORTH CHARLES ST, BALTIMORE, MD 21218-4363 USA SN 0048-7511 J9 REV AM HIST JI Rev. Am. Hist. PD DEC PY 2012 VL 40 IS 4 BP 572 EP 580 PG 9 WC History SC History GA 066PN UT WOS:000313232800009 ER PT J AU Bruscino, T AF Bruscino, Thomas TI Carrying the War to the Enemy: American Operational Art to 1945 SO REVIEWS IN AMERICAN HISTORY LA English DT Book Review C1 [Bruscino, Thomas] USA, Sch Adv Mil Studies, Washington, DC 20310 USA. RP Bruscino, T (reprint author), USA, Sch Adv Mil Studies, Washington, DC 20310 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU JOHNS HOPKINS UNIV PRESS PI BALTIMORE PA JOURNALS PUBLISHING DIVISION, 2715 NORTH CHARLES ST, BALTIMORE, MD 21218-4363 USA SN 0048-7511 J9 REV AM HIST JI Rev. Am. Hist. PD DEC PY 2012 VL 40 IS 4 BP 572 EP 580 PG 9 WC History SC History GA 066PN UT WOS:000313232800011 ER PT J AU Bruscino, T AF Bruscino, Thomas TI Barbarians and Brothers: Anglo-American Warfare, 1500-1865 SO REVIEWS IN AMERICAN HISTORY LA English DT Book Review C1 [Bruscino, Thomas] USA, Sch Adv Mil Studies, Washington, DC 20310 USA. RP Bruscino, T (reprint author), USA, Sch Adv Mil Studies, Washington, DC 20310 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU JOHNS HOPKINS UNIV PRESS PI BALTIMORE PA JOURNALS PUBLISHING DIVISION, 2715 NORTH CHARLES ST, BALTIMORE, MD 21218-4363 USA SN 0048-7511 J9 REV AM HIST JI Rev. Am. Hist. PD DEC PY 2012 VL 40 IS 4 BP 572 EP 580 PG 9 WC History SC History GA 066PN UT WOS:000313232800010 ER PT J AU Bruscino, T AF Bruscino, Thomas TI Nothing Less Than War: A New History of America's Entry into World War I SO REVIEWS IN AMERICAN HISTORY LA English DT Book Review C1 [Bruscino, Thomas] USA, Sch Adv Mil Studies, Washington, DC 20310 USA. RP Bruscino, T (reprint author), USA, Sch Adv Mil Studies, Washington, DC 20310 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU JOHNS HOPKINS UNIV PRESS PI BALTIMORE PA JOURNALS PUBLISHING DIVISION, 2715 NORTH CHARLES ST, BALTIMORE, MD 21218-4363 USA SN 0048-7511 J9 REV AM HIST JI Rev. Am. Hist. PD DEC PY 2012 VL 40 IS 4 BP 572 EP 580 PG 9 WC History SC History GA 066PN UT WOS:000313232800008 ER PT J AU Page, JM Prieto, EM Dumas, JE Zienkiewicz, KJ Wenke, JC Brown-Baer, P Guelcher, SA AF Page, Jonathan M. Prieto, Edna M. Dumas, Jerald E. Zienkiewicz, Katarzyna J. Wenke, Joseph C. Brown-Baer, Pamela Guelcher, Scott A. TI Biocompatibility and chemical reaction kinetics of injectable, settable polyurethane/allograft bone biocomposites SO ACTA BIOMATERIALIA LA English DT Article DE Injectable; Polyurethane; Lysine; Biocompatibility; Reactivity ID IN-VITRO; POLY(ETHYLENE GLYCOL); LYSINE DIISOCYANATE; GRAFT SUBSTITUTE; CELL-GROWTH; SCAFFOLDS; DEGRADATION; ADHESIVE; CYTOCOMPATIBILITY; BIODEGRADATION AB Injectable and settable bone grafts offer significant advantages over pre-formed implants due to their ability to be administered using minimally invasive techniques and to conform to the shape of the defect. However, injectable biomaterials present biocompatibility challenges due to the potential toxicity and ultimate fate of reactive components that are not incorporated in the final cured product. In this study the effects of stoichiometry and triethylenediamine (TEDA) catalyst concentration on the reactivity, injectability, and biocompatibility of two component lysine-derived polyurethane (PUR) biocomposites were investigated. Rate constants were measured for the reactions of water (a blowing agent resulting in the generation of pores), polyester triol, dipropylene glycol (DPG), and allograft bone particles with the isocyanate-terminated prepolymer using an in situ attenuated total reflection Fourier transform infrared spectroscopy technique. Based on the measured rate constants, a kinetic model predicting the conversion of each component with time was developed. Despite the fact that TEDA is a well-known urethane gelling catalyst, it was found to preferentially catalyze the blowing reaction with water relative to the gelling reactions by a ratio >17:1. Thus the kinetic model predicted that the prepolymer and water proceeded to full conversion, while the conversions of polyester triol and DPG were <70% after 24 h, which was consistent with leaching experiments showing that only non-cytotoxic polyester triol and DPG were released from the reactive PUR at early time points. The PUR biocomposite supported cellular infiltration and remodeling in femoral condyle defects in rabbits at 8 weeks, and there was no evidence of an adverse inflammatory response induced by unreacted components from the biocomposite or degradation products from the cured polymer. Taken together, these data underscore the utility of the kinetic model in predicting the biocompatibility of reactive biomaterials. (c) 2012 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved. C1 [Page, Jonathan M.; Prieto, Edna M.; Dumas, Jerald E.; Zienkiewicz, Katarzyna J.; Guelcher, Scott A.] Vanderbilt Univ, Dept Chem & Biomol Engn, Nashville, TN 37235 USA. [Page, Jonathan M.; Prieto, Edna M.; Dumas, Jerald E.; Guelcher, Scott A.] Vanderbilt Univ Sch Med, Ctr Bone Biol, Nashville, TN USA. [Wenke, Joseph C.; Brown-Baer, Pamela] USA, Inst Surg Res, San Antonio, TX USA. [Guelcher, Scott A.] Vanderbilt Univ, Dept Biomed Engn, Nashville, TN 37235 USA. RP Guelcher, SA (reprint author), Vanderbilt Univ, Dept Chem & Biomol Engn, Nashville, TN 37235 USA. EM scott.guelcher@vanderbilt.edu OI Brown Baer, Pamela/0000-0001-6964-1955 FU National Science Foundation through a CAREER award [DMR0847711]; Armed Forces Institute of Regenerative Medicine (AFIRM); US Army Institute of Surgical Research; US Army Medical Research and Materiel Command; US Navy, Office of Naval Research; US Air Force, Office of the Surgeon General; National Institutes of Health; Veterans Administration; Department of Defense, USA Medical Research Acquisition (ACQ) Activity [W81XWH-08-2-0034]; Orthopedic Extremity Trauma Research Program [W81XWH-07-1-0211] FX The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the Department of the Army or the Department of Defense. This work was supported by the National Science Foundation through a CAREER award to S.A.G. (DMR0847711), the Armed Forces Institute of Regenerative Medicine (AFIRM), and the US Army Institute of Surgical Research. AFIRM is managed and funded through the US Army Medical Research and Materiel Command, with additional funding from the US Navy, Office of Naval Research, the US Air Force, Office of the Surgeon General, the National Institutes of Health, the Veterans Administration, and local public and private match funding. The Rutgers-Cleveland Clinic Consortium of AFIRM is funded by the Department of Defense, USA Medical Research Acquisition (ACQ) Activity contract no. W81XWH-08-2-0034. The funding sources had no role in the decision to submit the manuscript for publication. This work was supported by the Orthopedic Extremity Trauma Research Program (W81XWH-07-1-0211). NR 56 TC 18 Z9 18 U1 6 U2 64 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1742-7061 J9 ACTA BIOMATER JI Acta Biomater. PD DEC PY 2012 VL 8 IS 12 BP 4405 EP 4416 DI 10.1016/j.actbio.2012.07.037 PG 12 WC Engineering, Biomedical; Materials Science, Biomaterials SC Engineering; Materials Science GA 060GR UT WOS:000312765000026 PM 22871639 ER PT J AU Folkes, PA Olver, K AF Folkes, P. A. Olver, K. TI Charge-induced series resistance switching in GaAs solar cells SO AIP ADVANCES LA English DT Article ID LIMITED CURRENTS; EFFICIENCY; INSULATOR; FILMS AB We report the observation of an abrupt decrease in the series resistance and a concurrent steep increase in the dark current at a threshold voltage, and subsequent hysteresis in the current-voltage characteristics of GaAs p-n junction solar cells. Our data suggests that the observed switch in the series resistance can be attributed to a thin insulating layer at the contact/semiconductor interface that contributes a voltage-and-light-dependent component to the solar cell series resistance. Copyright 2012 Author(s). This article is distributed under a Creative Commons Attribution 3.0 Unported License. [http://dx.doi.org/10.1063/1.4774033] C1 [Folkes, P. A.; Olver, K.] USA, Res Lab, Adelphi, MD 20783 USA. RP Folkes, PA (reprint author), USA, Res Lab, Adelphi, MD 20783 USA. NR 17 TC 1 Z9 1 U1 0 U2 13 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 2158-3226 J9 AIP ADV JI AIP Adv. PD DEC PY 2012 VL 2 IS 4 AR 042194 DI 10.1063/1.4774033 PG 6 WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied SC Science & Technology - Other Topics; Materials Science; Physics GA 061DX UT WOS:000312828700107 ER PT J AU Sabnis, S Charles, D AF Sabnis, Suhasini Charles, Doug TI Opportunities and Challenges: Security in eHealth SO BELL LABS TECHNICAL JOURNAL LA English DT Article AB eHealth is the transfer of health resources and health care by electronic means, and is enabled by communications technology through extensive information sharing and collaboration. Given the sensitive nature of medical information, and healthcare professionals' high degree of dependence on reliable records, issues of integrity, security, privacy, and confidentiality are of particular significance, and thus security must be clearly and effectively addressed by eHealth applications. This letter highlights the challenges, drivers, and standardization initiatives for security, compliance, and interoperability in health-related activities carried out over distance by means of information communication technologies. (c) 2012 Alcatel-Lucent. C1 [Sabnis, Suhasini] Bell Labs, Secur Technol Grp, Mountain View, CA USA. [Charles, Doug] Bell Labs, Murray Hill, NJ 07974 USA. [Charles, Doug] Univ Pittsburgh, Med Ctr, Telemed Joint Dev Project, Pittsburgh, PA 15260 USA. [Charles, Doug] Alcatel Lucent, Murray Hill, NJ USA. [Charles, Doug] USA, ARDEC, Washington, DC USA. RP Sabnis, S (reprint author), Bell Labs, Secur Technol Grp, Mountain View, CA USA. NR 3 TC 0 Z9 0 U1 2 U2 30 PU WILEY PERIODICALS, INC PI SAN FRANCISCO PA ONE MONTGOMERY ST, SUITE 1200, SAN FRANCISCO, CA 94104 USA SN 1089-7089 J9 BELL LABS TECH J JI Bell Labs Tech. J. PD DEC PY 2012 VL 17 IS 3 SI SI BP 105 EP 111 DI 10.1002/bltj.21561 PG 7 WC Computer Science, Information Systems; Engineering, Electrical & Electronic; Telecommunications SC Computer Science; Engineering; Telecommunications GA 062RT UT WOS:000312940000008 ER PT J AU Guo, JS He, H Chu, D Chen, RR AF Guo, Junsong He, Hui Chu, Deryn Chen, Rongrong TI OH--Binding Effects on Metallophthalocyanine Catalysts for O-2 Reduction Reaction in Anion Exchange Membrane Fuel Cells SO ELECTROCATALYSIS LA English DT Article DE Nonprecious metal catalysts; Transition-metal phthalocyanines; Oxygen reduction reaction; Density functional theory; Anion exchange membrane fuel cells ID OXYGEN REDUCTION; ELECTROCATALYTIC ACTIVITY; METAL PHTHALOCYANINES; IRON PHTHALOCYANINE; GRAPHITE-ELECTRODES; PYROLYTIC-GRAPHITE; TEMPERATURE-RANGE; CATHODE CATALYST; AC-IMPEDANCE; PERFORMANCE AB Electrocatalytic activity of the oxygen reduction reaction (ORR) on carbon-supported metallophthalocyanine (MPc/C, M = Fe, Co, Ni, and Mn) catalysts was studied with a rotating disk electrode (RDE) and a rotating ring-disk electrode (RRDE) in 0.1 M NaOH solutions. FePc/C shows better ORR activity than CoPc, NiPc, and MnPc in 0.1 M NaOH solutions. Density functional theory (DFT) calculations were performed to study the adsorption of O-2, H2O, OH, HOOH, and H2OO molecules on FePc, CoPc, NiPc, and MnPc molecule catalysts. Investigations using various MPc/C molecules as the cathode catalyst in anion exchange membrane fuel cells (AEMFCs) revealed that the catalysts, such as FePc/C, with high ORR activities observed with a RDE in 0.1 M NaOH solutions, do not warrant the high performance observed in the AEMFCs. DFT calculation results indicate that the FePc molecules are favorable for the adsorption of OH- rather than O-2 or H2O, especially under AEMFC operation conditions. Electrochemical impedance (EIS) spectra obtained while operating the AEMFCs revealed that the resistance of OH- transportation from the cathode to the anode depends on the cell potentials and the nature of the MPc molecules. As predicted by the DFT calculation results, the FePc/C catalyst shows the highest OH- transport resistant at a high current and a low cell voltage region. The bonding strength between OH- and MPc molecules is a critical factor that determines the performance of the MPc molecules in AEMFCs. The fundamental discrepancy between ORR activities observed with an RDE in a standard three-electrode cell and ORR activities observed in an AEMFC is discussed. C1 [Guo, Junsong; He, Hui; Chen, Rongrong] Indiana Univ Purdue Univ, Richard G Lugar Ctr Renewable Energy, Indianapolis, IN 46202 USA. [Chu, Deryn] USA, Res Lab, Adelphi, MD 20783 USA. RP Chen, RR (reprint author), Indiana Univ Purdue Univ, Richard G Lugar Ctr Renewable Energy, Indianapolis, IN 46202 USA. EM rochen@iupui.edu FU US Army Research Lab [W911NF-10-2-0075] FX This work was supported by the US Army Research Lab (grant no. W911NF-10-2-0075). NR 50 TC 12 Z9 12 U1 5 U2 82 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1868-2529 J9 ELECTROCATALYSIS-US JI Electrocatalysis PD DEC PY 2012 VL 3 IS 3-4 BP 252 EP 264 DI 10.1007/s12678-012-0106-1 PG 13 WC Chemistry, Physical; Electrochemistry SC Chemistry; Electrochemistry GA 058LB UT WOS:000312634100012 ER PT J AU Loveless, TD Kauppila, JS Jagannathan, S Ball, DR Rowe, JD Gaspard, NJ Atkinson, NM Blaine, RW Reece, TR Ahlbin, JR Haeffner, TD Alles, ML Holman, WT Bhuva, BL Massengill, LW AF Loveless, T. D. Kauppila, J. S. Jagannathan, S. Ball, D. R. Rowe, J. D. Gaspard, N. J. Atkinson, N. M. Blaine, R. W. Reece, T. R. Ahlbin, J. R. Haeffner, T. D. Alles, M. L. Holman, W. T. Bhuva, B. L. Massengill, L. W. TI On-Chip Measurement of Single-Event Transients in a 45 nm Silicon-on-Insulator Technology SO IEEE TRANSACTIONS ON NUCLEAR SCIENCE LA English DT Article; Proceedings Paper CT IEEE Radiation Effects Data Workshop (REDW) is Part of the Nuclear and Space Radiation Effects Conference (NSREC) CY JUL 16-20, 2012 CL Miami, FL SP IEEE Nucl & Plasma Sci Soc, Inst Elect & Elect Engineers Inc (IEEE) DE Built-in testing; CMOS; heavy ion testing; radiation effects; single-event transients; silicon-on-insulator (SOI) ID DIGITAL CMOS; PROPAGATION; INVERTERS; CIRCUIT; CHAINS AB Direct observation of fast-transient single event signatures often involves considerable uncertainty due to the limitations of monitoring circuitry. A built-in-self-test circuit for the measurement of single-event transients (SET) has been implemented in a 45 nm partially depleted silicon-on-insulator technology that allows for the extraction of measurement-induced uncertainty. SET pulse width data from heavy-ion experiments are provided and compared to technology computer aided design simulations. A method for compensating for the measurement bias and skew is provided. C1 [Loveless, T. D.; Kauppila, J. S.; Ball, D. R.; Rowe, J. D.; Haeffner, T. D.; Alles, M. L.; Holman, W. T.; Bhuva, B. L.; Massengill, L. W.] Vanderbilt Univ, Inst Space & Def Elect, Nashville, TN 37212 USA. [Jagannathan, S.; Gaspard, N. J.; Atkinson, N. M.; Blaine, R. W.; Reece, T. R.] Vanderbilt Univ, Dept Elect Engn & Comp Sci, Nashville, TN 37235 USA. [Blaine, R. W.] US Mil Acad, Dept Elect Engn & Comp Sci, West Point, NY 10996 USA. [Loveless, T. D.; Kauppila, J. S.; Ball, D. R.; Rowe, J. D.; Haeffner, T. D.; Alles, M. L.; Holman, W. T.; Bhuva, B. L.; Massengill, L. W.] Vanderbilt Univ, Dept Elect Engn & Comp Sci, Nashville, TN 37212 USA. RP Loveless, TD (reprint author), Vanderbilt Univ, Inst Space & Def Elect, Nashville, TN 37212 USA. EM daniel.loveless@vanderbilt.edu RI Loveless, Thomas/G-9420-2011; Loveless, Thomas/C-7132-2016; OI Reece, Trey/0000-0002-5586-4573 FU Defense Threat Reduction Agency Rad-Hard Microelectronics Program FX Manuscript received July 13, 2012; revised August 31, 2012; accepted September 01, 2012. Date of publication October 23, 2012; date of current version December 11, 2012. This work was supported by the Defense Threat Reduction Agency Rad-Hard Microelectronics Program. NR 16 TC 15 Z9 16 U1 0 U2 4 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0018-9499 EI 1558-1578 J9 IEEE T NUCL SCI JI IEEE Trans. Nucl. Sci. PD DEC PY 2012 VL 59 IS 6 BP 2748 EP 2755 DI 10.1109/TNS.2012.2218257 PN 1 PG 8 WC Engineering, Electrical & Electronic; Nuclear Science & Technology SC Engineering; Nuclear Science & Technology GA 056JX UT WOS:000312486000015 ER PT J AU Blaine, RW Atkinson, NM Kauppila, JS Armstrong, SE Hooten, NC Loveless, TD Warner, JH Holman, WT Massengill, LW AF Blaine, R. W. Atkinson, N. M. Kauppila, J. S. Armstrong, S. E. Hooten, N. C. Loveless, T. D. Warner, J. H. Holman, W. T. Massengill, L. W. TI Differential Charge Cancellation (DCC) Layout as an RHBD Technique for Bulk CMOS Differential Circuit Design SO IEEE TRANSACTIONS ON NUCLEAR SCIENCE LA English DT Article; Proceedings Paper CT IEEE Radiation Effects Data Workshop (REDW) is Part of the Nuclear and Space Radiation Effects Conference (NSREC) CY JUL 16-20, 2012 CL Miami, FL SP IEEE Nucl & Plasma Sci Soc, Inst Elect & Elect Engineers Inc (IEEE) DE Layout; Transistors; Circuit synthesis; Transient analysis; Operational amplifiers; CMOS technology; single-event effects; Charge sharing; DCC; differential design; operational amplifier; RHBD ID 2-PHOTON ABSORPTION AB A novel RHBD technique utilizing charge sharing to mitigate single-event voltage transients in differential circuits is demonstrated experimentally. Differential charge cancellation (DCC) layout leverages the inherent common-mode rejection of differential circuits to mitigate voltage transients induced by ion strikes. A simple layout variation transforms normally single-ended error signals into common-mode signals that are mitigated by the differential signal path. This layout change maintains the matching achieved via a standard common-centroid layout but incurs negligible area penalty. DCC layouts can provide more than an order of magnitude reduction in sensitive area across a wide range of laser energies. Evidence is presented that suggests this hardening technique will be even more effective for angled strikes and smaller device geometries. C1 [Blaine, R. W.; Atkinson, N. M.; Kauppila, J. S.; Hooten, N. C.; Holman, W. T.; Massengill, L. W.] Vanderbilt Univ, Dept Elect Engn & Comp Sci, Nashville, TN 37212 USA. [Blaine, R. W.] US Mil Acad, Dept Elect Engn & Comp Sci, West Point, NY 10996 USA. [Armstrong, S. E.] NAVSEA Crane, Crane, IN 47522 USA. [Warner, J. H.] USN, Res Lab, Washington, DC 20375 USA. RP Blaine, RW (reprint author), Vanderbilt Univ, Dept Elect Engn & Comp Sci, Nashville, TN 37212 USA. EM raymond.w.blaine@vanderbilt.edu; nick.atkinson@van-derbilt.edu; j.kauppila@vanderbilt.edu; sarah.armstrong@navy.mil; nicholas.c.hooten@vanderbilt.edu; Jeffrey.warner@nrl.navy.mil; tim.holman@vanderbilt.edu; lloyd.massengill@vanderbilt.edu RI Loveless, Thomas/G-9420-2011; Loveless, Thomas/C-7132-2016 FU DTRA Radiation Hardened Microelectronics [HDTRA1-09-C-0038]; Draper Laboratories under University RD Program FX This work was supported in part by the DTRA Radiation Hardened Microelectronics contract HDTRA1-09-C-0038 and Draper Laboratories under a 2011 University R&D Program. NR 8 TC 9 Z9 9 U1 0 U2 2 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0018-9499 EI 1558-1578 J9 IEEE T NUCL SCI JI IEEE Trans. Nucl. Sci. PD DEC PY 2012 VL 59 IS 6 BP 2867 EP 2871 DI 10.1109/TNS.2012.2222441 PN 1 PG 5 WC Engineering, Electrical & Electronic; Nuclear Science & Technology SC Engineering; Nuclear Science & Technology GA 056JX UT WOS:000312486000032 ER PT J AU Pinson, AO AF Pinson, Ariane O. TI Meetings at the Margins: Prehistoric Cultural Interactions in the Intermountain West SO JOURNAL OF ANTHROPOLOGICAL RESEARCH LA English DT Book Review C1 [Pinson, Ariane O.] USA, Corps Engineers, Washington, DC 20310 USA. RP Pinson, AO (reprint author), USA, Corps Engineers, Washington, DC 20310 USA. NR 1 TC 0 Z9 0 U1 0 U2 1 PU UNIV NEW MEXICO, DEPT ANTHROPOL PI ALBUQUERQUE PA MSC01 1040, ANTHROPOLOGY 1, UNIV NEW MEXICO, ALBUQUERQUE, NM 87131 USA SN 0091-7710 J9 J ANTHROPOL RES JI J. Anthropol. Res. PD WIN PY 2012 VL 68 IS 4 BP 571 EP 573 PG 3 WC Anthropology SC Anthropology GA 063BI UT WOS:000312970400022 ER PT J AU Jones, KA Batyrev, IG AF Jones, K. A. Batyrev, I. G. TI The structure of dislocations in (In,Al,Ga)N wurtzite films grown epitaxially on (0001) or (11(2)over-bar2) GaN or AlN substrates SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID MISFIT DISLOCATIONS; INGAN EPILAYERS; GENERATION AB When dislocations have to be nucleated in the film to accommodate the lattice mismatch with the substrate, the shear stress acting in the glide plane, projection of the edge component of the Burgers vector lying in the growth plane, shear stress required for the dislocation to glide, and ability to decompose into partial dislocation pairs with an associated stacking fault are considered. This is done for growth on the (0001) or (11 (2) over bar2) substrates by calculating the angle the slip plane, h, makes with the growth plane, length of the Burgers vector, b, angle between b and the dislocation line, l, projection of b onto the normal to l lying in the growth plane, and planar density of h. The planar density is used as a measure of the shear stress required to move the dislocation, and it is computed by determining the interplanar spacing, d, and accounting for the atoms that lie in parallel planes, which are made possible by the fact that the wurtzite unit cell contains four atoms per lattice point. Only dislocations with pyramidal glide planes are considered for growth on the (0001) substrate because the plane strain generated by the lattice mismatch does not generate any shear stress in the basal or prismatic planes. Only one member of the family of planes is considerate for this growth plane because of its high symmetry. For growth on the (11 (2) over bar2) plane both slip in the basal plane and the prismatic plane normal to the Burgers vector in it are examined. [http://dx.doi.org/10.1063/1.4767683] C1 [Jones, K. A.] USA, Res Lab, SEDD, Adelphi, MD 20873 USA. [Batyrev, I. G.] USA, Res Lab, WMRD, Aberdeen Proving Ground, MD 21001 USA. RP Jones, KA (reprint author), USA, Res Lab, SEDD, Adelphi, MD 20873 USA. NR 32 TC 3 Z9 3 U1 3 U2 45 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD DEC 1 PY 2012 VL 112 IS 11 AR 113507 DI 10.1063/1.4767683 PG 10 WC Physics, Applied SC Physics GA 056LI UT WOS:000312490700025 ER PT J AU Mal, S Nori, S Mula, S Narayan, J Prater, JT AF Mal, Siddhartha Nori, Sudhakar Mula, Suhrit Narayan, J. Prater, J. T. TI Defect mediated reversible ferromagnetism in Co and Mn doped zinc oxide epitaxial films SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID DILUTED MAGNETIC SEMICONDUCTOR; ZNO THIN-FILMS; ROOM-TEMPERATURE AB We have introduced defects in ZnO (undoped and doped with Co and Mn) epitaxial thin films using laser irradiation from nanosecond laser pulses and thermal annealing in oxygen ambient. In contrast to the as grown samples, the laser irradiated films show a significant increase in conductivity, enhancement in UV emission, while maintaining the same wurtzite crystal structure. Room-temperature ferromagnetism (RTFM) is observed in laser-irradiated samples, which increased with the number of laser pulses up to a certain value where magnetic moment saturates. The induced ferromagnetism as well as the enhanced electrical conductivity can be reversed with thermal annealing in oxygen ambient. The magnetization in Co and Mn doped films was found to be strong function of growth conditions and defect concentration. X-ray diffraction and optical absorption experiments suggested a 2+ valance state and tetrahedral coordination for both Co and Mn ions. There is a simultaneous increase in n-type electrical conductivity with the number of laser pulses and continue to exhibit semiconducting behavior in both undoped and doped films. The saturation magnetization was found to be 0.08 mu(B)/Co and 0.05 mu(B)/Mn, much lower than 3.0 mu(B)/Co and 5.0 mu(B)/Mn, indicating the prominent role of intrinsic defects in RTFM with some contribution from Co2+-oxygen vacancy complexes. We propose a unified mechanism based upon introduction of intrinsic defects to explain RTFM and n-type conductivity enhancements during pulsed laser and thermal annealing. (C) 2012 American Institute of Physics. [http://dx.doi.org/10.1063/1.4768721] C1 [Mal, Siddhartha; Nori, Sudhakar; Mula, Suhrit; Narayan, J.] N Carolina State Univ, Dept Mat Sci & Engn, Raleigh, NC 27695 USA. [Mula, Suhrit] Natl Inst Technol, Dept Met & Mat Engn, Rourkela 769008, India. [Prater, J. T.] USA, Div Mat Sci, Res Off, Res Triangle Pk, NC 27709 USA. RP Mal, S (reprint author), N Carolina State Univ, Dept Mat Sci & Engn, Box 7907, Raleigh, NC 27695 USA. EM smal@ncsu.edu RI Nori, Sudhakar/E-8111-2010 FU Army Research Office [W911NF-04-D-0003]; National Science Foundation [NSF 0653722] FX The authors were pleased to acknowledge the support of the Army Research Office under Grant W911NF-04-D-0003, and the National Science Foundation under Grant NSF 0653722. NR 38 TC 10 Z9 10 U1 1 U2 32 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD DEC 1 PY 2012 VL 112 IS 11 AR 113917 DI 10.1063/1.4768721 PG 6 WC Physics, Applied SC Physics GA 056LI UT WOS:000312490700079 ER PT J AU Sarno, MU Sidow, SJ Looney, SW Lindsey, KW Niu, LN Tay, FR AF Sarno, Michelle U. Sidow, Stephanie J. Looney, Stephen W. Lindsey, Kimberly W. Niu, Li-na Tay, Franklin R. TI Canal and Isthmus Debridement Efficacy of the VPro EndoSafe Negative-pressure Irrigation Technique SO JOURNAL OF ENDODONTICS LA English DT Article DE Closed system; collagen; isthmus; negative pressure; side-vented needle ID HUMAN MANDIBULAR MOLARS; COMPUTATIONAL FLUID-DYNAMICS; BIO-MOLECULAR FILM; EX-VIVO MODEL; IN-VIVO; CLOSED-SYSTEM; ROTARY INSTRUMENTATION; AGITATION TECHNIQUES; COMPUTED-TOMOGRAPHY; CLEANING EFFICACY AB Introduction: This study compared canal and isthmus debridement efficacies between side-vented needle irrigation (SNI) and the VPro EndoSafe (VPro) negative-pressure device (Vista Dental, Racine, WI) in mesial roots of mandibular first molars with narrow isthmuses in a closed-canal design. Methods: Twenty teeth with narrow isthmuses were selected using micro computed tomography scanning. Collagen solution was reconstituted with 1% NH4OH to simulate debris and injected into canals via vacuum. Canals were instrumented to size 40/.04. Final irrigation was performed with 17% EDTA and 6% NaOCl using SNI with a 30-G needle or the VPro system. Roots were demineralized, and Masson trichrome stained sections were prepared at 1.2 to 3.2 mm from the anatomic apex for a total of 6 canal levels. Debris-filled areas within the canals and isthmuses were measured using ImageJ software (National Institutes of Health, Bethesda, MD) and statistically analyzed using repeated-measures analysis. Results: There was no significant difference between techniques and debridement efficacy among the 6 levels within the canal (P = .108). The debridement efficacy at 1.6 mm differed significantly from that at 3.2 mm. VPro had significantly more debris at isthmus levels 2.0 and 2.4 mm than SNI (P = .009). A significant difference was observed between the canal and the isthmus (P < .001). Neither VPro nor SNI removed debris completely from the apical third or isthmus. Conclusions: VPro EndoSafe did not differ significantly from SNI in the overall debridement efficacy in the apical third of mesial roots of mandibular first molars. (J Endod. 2012;38:1631-1634) C1 [Sidow, Stephanie J.] USA, Dent Activ, Dept Endodont, Ft Gordon, GA 30905 USA. [Looney, Stephen W.] Georgia Hlth Sci Univ, Dept Biostat, Augusta, GA USA. [Looney, Stephen W.] Georgia Hlth Sci Univ, Dept Oral Hlth & Diagnost Sci, Augusta, GA USA. [Niu, Li-na] Fourth Mil Med Univ, Xian 710032, Peoples R China. [Tay, Franklin R.] Georgia Hlth Sci Univ, Coll Dent Med, Dept Endodont, Augusta, GA USA. RP Sidow, SJ (reprint author), USA, Dent Activ, Dept Endodont, Ft Gordon, Ft Gordon, GA 30905 USA. EM stephanie.sidow@us.army.mil NR 34 TC 2 Z9 2 U1 0 U2 6 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0099-2399 J9 J ENDODONT JI J. Endod. PD DEC PY 2012 VL 38 IS 12 BP 1631 EP 1634 DI 10.1016/j.joen.2012.09.002 PG 4 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA 056HS UT WOS:000312479600016 PM 23146651 ER PT J AU Lamichhane, KM Babcock, RW Turnbull, SJ Schenck, S AF Lamichhane, Krishna M. Babcock, Roger W., Jr. Turnbull, Steve J. Schenck, Susan TI Molasses enhanced phyto and bioremediation treatability study of explosives contaminated Hawaiian soils SO JOURNAL OF HAZARDOUS MATERIALS LA English DT Article DE RDX; HMX; Bioremediation; Phytoremediation; Green house study ID HEXAHYDRO-1,3,5-TRINITRO-1,3,5-TRIAZINE RDX; FATE; HMX; BIODEGRADATION; TNT; DEGRADATION; PLANTS AB A 15-week treatability study was conducted in a greenhouse to evaluate the potential effects of molasses on the bioremediation and phytoremediation potential of Guinea Grass (Panicum maximum) for treating energetic contaminated soil from the open burn/open detonation area of the Makua Military Reservation, Oahu, HI (USA). The energetics in the soil were royal demolition explosive (RDX) and high-melting explosive (HMX). Among the 6 treatments employed in this study, enhanced removal of RDX was observed from treatments that received molasses and went to completion. The RDX degradation rates in treatments with molasses diluted 1:20 and 1:40 were comparable suggesting that the lower dose worked as well as the higher dose. Treatments without molasses degraded RDX slowly and residuals remained after 15 weeks. The bacterial densities in molasses-treated units were much greater than those without molasses. Phytoremediation alone seems to have little effect on RDX disappearance. For HMX, neither bioremediation nor phytoremediation was found to be useful in reducing the concentration within the experimental period. The concentrations of nitrogen and phosphorous in the soil did not change significantly during the experiment, however, a slight increase in soil pH was observed in all treatments. The study showed that irrigating with diluted molasses is effective at enhancing RDX degradation mainly in the root zone and just below it. The long term sustainability of active training ranges can be enhanced by bioremediation using molasses treatments to prevent RDX deposited by on-going operations from migrating through the soil to groundwater and off-site. (C) 2012 Elsevier B.V. All rights reserved. C1 [Lamichhane, Krishna M.; Babcock, Roger W., Jr.] Univ Hawaii, Dept Civil & Environm Engn, Honolulu, HI 96822 USA. [Turnbull, Steve J.] US Army Garrison, Directorate Publ Works, Schofield Barracks, HI 96857 USA. [Schenck, Susan] Hawaii Agr Res Ctr, Aiea, HI 96701 USA. RP Babcock, RW (reprint author), Univ Hawaii, Dept Civil & Environm Engn, 2540 Dole St,Holmes 283, Honolulu, HI 96822 USA. EM lamichha@hawaii.edu; rbabcock@hawaii.edu; steve.j.turnbull@us.army.mil; sschenck@harc-hspa.com FU project entitled "Enhanced Degradation of Energetic Contamination in Live Fire Ranges Located in Tropical Environments" [W912HQ-06-C-0049]; Environmental Security Technology Certification Program (ESTCP); U.S. Army Garrison Hawai'i FX This green house treatability study is the part of the project entitled "Enhanced Degradation of Energetic Contamination in Live Fire Ranges Located in Tropical Environments (Contract No. W912HQ-06-C-0049)". This project was funded under the Environmental Security Technology Certification Program (ESTCP) and U.S. Army Garrison Hawai'i. The authors would also like to acknowledge Nicole Scheman for her help on this study. NR 30 TC 9 Z9 9 U1 1 U2 28 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0304-3894 J9 J HAZARD MATER JI J. Hazard. Mater. PD DEC PY 2012 VL 243 BP 334 EP 339 DI 10.1016/j.jhazmat.2012.10.043 PG 6 WC Engineering, Environmental; Engineering, Civil; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA 058BL UT WOS:000312609000041 PM 23164624 ER PT J AU Muinonen, K Videen, G AF Muinonen, Karri Videen, Gorden TI A phenomenological single scatterer for studies of complex particulate media SO JOURNAL OF QUANTITATIVE SPECTROSCOPY & RADIATIVE TRANSFER LA English DT Article; Proceedings Paper CT 13th Conference on Electromagnetic and Light Scattering (ELS) CY SEP 26-30, 2011 CL Taormina, ITALY SP Dipartimento Fisica della Materia Ingn Elettronica, Univ Messian, Consiglio Nazl delle Ric, Ist Processi Chimico Fisici (CNR-IPCF), Accademia Peloritana Pericolanti, U S Army Int Technol Ctr-Atlantic Res Div (USAITC-A), U S Off Naval Res Global-Conf Support Program (ONR-CSP), Fondazione Bonino-Pulejo (FBP), NanoAntenna European Res Project DE Light scattering; Polarization; Small particle; Coherent backscattering; Radiative transfer ID COHERENT BACKSCATTERING; MATRICES; PARTICLES AB A phenomenological single scatterer is presented for multiple-scattering studies involving complex random media. The single-scattering albedo is used to describe the proportion of scattering to absorption. A double Henyey-Greenstein function is introduced for the scattering phase function P-11, allowing for realistic forward and backward lobes using the forward, backward, and total asymmetry parameters. The scattering matrix divided by P-11 is defined as a weighted sum of modified electric-dipole and magnetic-dipole matrices. Angular stretching is introduced in these matrices by incorporating eccentricities in the scattering-angle arguments, allowing for single scatterers that are negatively polarizing in the backscattering regime and that show their maximum positive polarization at scattering angle differing from 90 degrees. For the two types of scatterers separately, the scattering matrices are pure 4 x 4 Mueller matrices that derive from 2 x 2 Jones scattering amplitude matrices. In order to illustrate the application of the phenomenological scatterer, radiative-transfer coherent-bacicscattering computations are carried out for spherical media of such scatterers, assuming that attenuation due to extinction is exponential and described by the extinction mean-free-path length. The results are seen to be relevant for modeling photometric, polarimetric, and spectroscopic observations of small Solar System objects. (C) 2012 Elsevier Ltd. All rights reserved. C1 [Muinonen, Karri] Univ Helsinki, Dept Phys, FI-00014 Helsinki, Finland. [Muinonen, Karri] Finnish Geodet Inst, FI-02431 Masala, Finland. [Videen, Gorden] USA, Res Lab, Adelphi, MD 20783 USA. [Videen, Gorden] Space Sci Inst, Boulder, CO 80301 USA. RP Muinonen, K (reprint author), Univ Helsinki, Dept Phys, POB 64, FI-00014 Helsinki, Finland. EM Karri.Muinonen@helsinki.fi NR 12 TC 7 Z9 7 U1 0 U2 5 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0022-4073 J9 J QUANT SPECTROSC RA JI J. Quant. Spectrosc. Radiat. Transf. PD DEC PY 2012 VL 113 IS 18 SI SI BP 115 EP 120 DI 10.1016/j.jqsrt.2012.07.003 PG 6 WC Optics; Spectroscopy SC Optics; Spectroscopy GA 059DX UT WOS:000312685700011 ER PT J AU Petrov, D Shkuratov, Y Videen, G AF Petrov, Dmitry Shkuratov, Yuriy Videen, Gorden TI Light scattering by arbitrary shaped particles with rough surfaces: Sh-matrices approach SO JOURNAL OF QUANTITATIVE SPECTROSCOPY & RADIATIVE TRANSFER LA English DT Article; Proceedings Paper CT 13th Conference on Electromagnetic and Light Scattering (ELS) CY SEP 26-30, 2011 CL Taormina, ITALY SP Dipartimento Fisica della Materia Ingn Elettronica, Univ Messian, Consiglio Nazl delle Ric, Ist Processi Chimico Fisici (CNR-IPCF), Accademia Peloritana Pericolanti, U S Army Int Technol Ctr-Atlantic Res Div (USAITC-A), U S Off Naval Res Global-Conf Support Program (ONR-CSP), Fondazione Bonino-Pulejo (FBP), NanoAntenna European Res Project DE Light Scattering; Shape matrix; Sh-matrix; T-matrix; Surface roughness ID GAUSSIAN RANDOM PARTICLES; ELECTROMAGNETIC SCATTERING; SPHEROIDAL PARTICLES; COHERENT BACKSCATTER; FINITE-CYLINDER; CAPSULE; MOON AB We continue to develop a modification of the T-matrix method that allows efficient studies of scattering properties of ensembles of independent irregular particles of different size. The advantage of the modification is quick calculations using the so-called shape-matrices (Sh-matrices), which allow more rapid calculations of particles of different size and can be used for averaging scattering properties over particle size. We extend this approach to light scattering by arbitrarily shaped particles with rough surfaces, including rough cubes and Gaussian spheres. Calculations of circular polarization ratio mu(c) for small particles of different shape and roughness show conspicuous surges at low phase angles <10 degrees that cannot be treated as a manifestation of the coherent backscattering effect. This contradicts the Hapke et al. (Icarus 1998;133:89) interpretation of the mu(c) effect found for the lunar regolith that includes both large particles which are mainly aggregates of small grains and a significant portion of dust. Published by Elsevier Ltd. C1 [Petrov, Dmitry; Shkuratov, Yuriy] Kharkov Natl Univ, Astron Inst, UA-61022 Kharkov, Ukraine. [Shkuratov, Yuriy] NASU, Inst Radio Astron, UA-61002 Kharkov, Ukraine. [Videen, Gorden] USA, Res Lab, AMSRL CI EM, Adelphi, MD 20783 USA. RP Petrov, D (reprint author), Kharkov Natl Univ, Astron Inst, 35 Sumskaya St, UA-61022 Kharkov, Ukraine. EM petrov@astron.kharkov.ua NR 39 TC 3 Z9 3 U1 0 U2 17 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0022-4073 J9 J QUANT SPECTROSC RA JI J. Quant. Spectrosc. Radiat. Transf. PD DEC PY 2012 VL 113 IS 18 SI SI BP 136 EP 148 DI 10.1016/j.jqsrt.2012.04.016 PG 13 WC Optics; Spectroscopy SC Optics; Spectroscopy GA 059DX UT WOS:000312685700013 ER PT J AU Shkuratov, Y Kaydash, V Korokhin, V Velikodsky, Y Petrov, D Zubko, E Stankevich, D Videen, G AF Shkuratov, Y. Kaydash, V. Korokhin, V. Velikodsky, Y. Petrov, D. Zubko, E. Stankevich, D. Videen, G. TI A critical assessment of the Hapke photometric model SO JOURNAL OF QUANTITATIVE SPECTROSCOPY & RADIATIVE TRANSFER LA English DT Article; Proceedings Paper CT 13th Conference on Electromagnetic and Light Scattering (ELS) CY SEP 26-30, 2011 CL Taormina, ITALY SP Dipartimento Fisica della Materia Ingn Elettronica, Univ Messina, Consiglio Nazl delle Ric, Ist Processi Chimico Fisici (CNR-IPCF), Accademia Peloritana Pericolanti, U S Army Int Technol Ctr-Atlantic Res Div (USAITC-A), U S Off Naval Res Global-Conf Support Program (ONR-CSP), Fondazione Bonino-Pulejo (FBP), NanoAntenna European Res Project DE Hapke model; Photometry; Lunar photometry ID BIDIRECTIONAL REFLECTANCE SPECTROSCOPY; GEOMETRICAL-OPTICS APPROXIMATION; REGOLITH-LIKE SURFACES; DISCRETE RANDOM-MEDIA; PARTICULATE SURFACES; RADIATIVE-TRANSFER; LIGHT-SCATTERING; COHERENT BACKSCATTERING; NEGATIVE POLARIZATION; OPAQUE PARTICLES AB The photometric model developed by Hapke is commonly used to study surface structure and composition of atmosphereless celestial bodies using photometric measurements. However, this model has shortcomings that weaken its applications. For instance, some of the model parameters are empirical and mutually dependent. Moreover, the photometric model is eclectic and approximate; e.g., (1) the model simultaneously considers the single-scattering phase-function as backscattering and isotropic when describing, respectively, incoherent and coherent multiple scattering, which is physically impossible; (2) the approximation of the incoherent multiple scattering function takes into account the function anisotropy for the incident and emergent angles, but ignores the anisotropy for the azimuth. angle that is of equal importance; (3) the model also ignores the dependence of the shadow-hiding effect of particles and coherent-backscattering enhancement on illuminating/viewing geometry, accounting only for the phase-angle component; (4) the azimuthal dependence of the shadow-hiding effect on random topographies is introduced ad hoc and is not verified; moreover, the shadow phase function may produce a non-physical maximum at large angles of viewing. We test the Hapke model using a computer simulation of ray-tracing in particulate surfaces, showing significant differences between the Hapke model and the ray-tracing results. We also apply the Hapke model to the interpretation of laboratory photometry of several well-characterized powdered samples measured in two wavelengths. The samples were measured in three states: as particles in air, as a particulate surface formed by freely spilled particles, and after compressing the particulate surface. The Hapke model parameters were completely inconsistent in the interpretation of these laboratory data. Our attempt to map the Hapke parameters using a series of telescopic calibrated images of the Moon acquired at different phase angles demonstrates that the model does not provide a physically meaningful distribution of its parameters. We also suggest that the small increase of the circular polarization ratio pc at decreasing phase angle (<10 degrees), which is observed for lunar samples, is not evidence of the coherent-backscattering effect of the Moon. We suggest that Clementine observations carried out with the UV-Vis and NIR cameras demonstrate that the coherent-backscattering effect exists only for bright lunar surface areas with albedo higher than 30%. Published by Elsevier Ltd. C1 [Videen, G.] Space Sci Inst, Boulder, CO 80301 USA. [Shkuratov, Y.; Kaydash, V.; Korokhin, V.; Velikodsky, Y.; Petrov, D.; Zubko, E.; Stankevich, D.] Kharkov Natl Univ, Astron Inst Kharkov, UA-61022 Kharkov, Ukraine. [Shkuratov, Y.] NASU, Inst Radio Astron, UA-61002 Kharkov, Ukraine. [Zubko, E.] Univ Helsinki, Dept Phys, FI-00014 Helsinki, Finland. [Videen, G.] USA, Res Lab, Adelphi, MD 20783 USA. RP Videen, G (reprint author), Space Sci Inst, 4750 Walnut St,Suite 205, Boulder, CO 80301 USA. EM gvideen@arl.army.mil OI Korokhin, Viktor/0000-0002-1911-3422; Velikodsky, Yuri/0000-0002-8219-128X NR 112 TC 24 Z9 24 U1 1 U2 16 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0022-4073 EI 1879-1352 J9 J QUANT SPECTROSC RA JI J. Quant. Spectrosc. Radiat. Transf. PD DEC PY 2012 VL 113 IS 18 SI SI BP 161 EP 186 DI 10.1016/j.jqsrt.2012.04.010 PG 26 WC Optics; Spectroscopy SC Optics; Spectroscopy GA 059DX UT WOS:000312685700016 ER PT J AU Kocifaj, M Klacka, J Videen, G Kohut, I AF Kocifaj, Miroslav Klacka, Jozef Videen, Gorden Kohut, Igor TI Optical properties of a polydispersion of small charged cosmic dust particles SO JOURNAL OF QUANTITATIVE SPECTROSCOPY & RADIATIVE TRANSFER LA English DT Article; Proceedings Paper CT 13th Conference on Electromagnetic and Light Scattering (ELS) CY SEP 26-30, 2011 CL Taormina, ITALY SP Dipartimento Fisica della Materia Ingn Elettronica, Univ Messian, Consiglio Nazl delle Ric, Ist Processi Chimico Fisici (CNR-IPCF), Accademia Peloritana Pericolanti, U S Army Int Technol Ctr-Atlantic Res Div (USAITC-A), U S Off Naval Res Global-Conf Support Program (ONR-CSP), Fondazione Bonino-Pulejo (FBP), NanoAntenna European Res Project DE Light scattering; Charged spherical particles; Nanosized cosmic dust; Polydisperse systems ID ELECTROMAGNETIC-WAVES; SILICON NANOPARTICLES; SIZE DISTRIBUTION; EXTINCTION; SCATTERING; GRAINS; SPHERE AB Recent studies of extended red emissions suggest the presence of very small dust particles in the Universe. The sizes of these particles can be some nanometers, thus placing the theoretical problem of their light scattering within the Rayleigh regime. Assuming the wavelength varies over visible or near infrared spectral bands, the efficiency factor for extinction Q(ext) can be written as a power expansion based on size parameter x. Rayleigh theory dictates that the first term dominates; thus. Q(ext) is either proportional to x for absorbing particles, or x(4) if the particles are composed of non-absorbing materials. In the latter case, Q(ext) is equivalent to the scattering efficiency Q(sca). However, the optical response of charged particles can differ from that of uncharged particles, especially if the surface electric potential is sufficiently large or if resonance conditions are fulfilled. In this study we compare the optical properties of a polydispersion of electrically charged and electrically neutral particles. The resulting optical thickness of such particle ensembles is derived in analytical form and the numerical computations are made for two particle distributions, specifically the power law and modified gamma function. One of the important findings is that the contribution of the smallest nanometer-sized particles to the total optical thickness may be underestimated lithe effects of the electric charges are ignored. The distinct optical behavior of these particles also can have an impact on the emission features, since their different optical absorption implies a different temperature of the particle. Finally, the scattering phase function is weakly dependent on electric charges of the scattering particles. (C) 2012 Elsevier Ltd. All rights reserved. C1 [Kocifaj, Miroslav] Slovak Acad Sci, Astron Inst, Bratislava 84504, Slovakia. [Klacka, Jozef] Comenius Univ, Fac Math Phys & Informat, Bratislava 84248, Slovakia. [Videen, Gorden] USA, Res Lab, AMSRD ARL CI ES, Adelphi, MD 20783 USA. [Kohut, Igor] Slovak Acad Sci, Inst Geophys, Bratislava 84528, Slovakia. RP Kocifaj, M (reprint author), Slovak Acad Sci, Astron Inst, Dubravska Cesta 9, Bratislava 84504, Slovakia. EM kocifaj@savba.sk; klacka@fmph.uniba.sk; gorden.w.videen.civ@mail.mil; geofkohi@savba.sk NR 19 TC 5 Z9 5 U1 0 U2 5 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0022-4073 J9 J QUANT SPECTROSC RA JI J. Quant. Spectrosc. Radiat. Transf. PD DEC PY 2012 VL 113 IS 18 SI SI BP 291 EP 296 DI 10.1016/j.jqsrt.2012.05.014 PG 6 WC Optics; Spectroscopy SC Optics; Spectroscopy GA 059DX UT WOS:000312685700030 ER PT J AU Cook, JB Shaha, JS Rowles, DJ Bottoni, CR Shaha, SH Tokish, JM AF Cook, Jay B. Shaha, James S. Rowles, Douglas J. Bottoni, Craig R. Shaha, Steven H. Tokish, John M. TI Early failures with single clavicular transosseous coracoclavicular ligament reconstruction SO JOURNAL OF SHOULDER AND ELBOW SURGERY LA English DT Article DE Acromioclavicular; coracoclavicular; GraftRope; reconstruction; failure; shoulder ID ACROMIOCLAVICULAR JOINT RECONSTRUCTION; SEMITENDINOSUS TENDON; DISLOCATIONS; SEPARATIONS; MANAGEMENT; INJURIES; GRAFTS AB Introduction: Coracoclavicular (CC) ligament reconstruction remains a challenging procedure. The ideal reconstruction is biomechanically strong, allows direct visualization of passage around the coracoid, and is minimally invasive. Few published reports have evaluated arthroscopic techniques with a single clavicular tunnel and transcoracoid reconstruction. One such report noted early excellent results, butwithout specific outcome measures. This study reports the clinical and radiographic results of a minimally invasive, arthroscopically assisted technique of CC ligament reconstruction using a transcoracoid and single clavicular tunnel technique. Materials and methods: A retrospective review was performed of 10 consecutive repairs in 9 active duty patients who underwent CC ligament reconstruction with the GraftRope (Arthrex, Naples FL, USA). All reconstructions were performed according to the manufacturer's technique by a single, fellowship-trained surgeon. Medical records and radiographs were evaluated for demographics, operative details, loss of reduction, and return to duty. Results: In 8 of 10 repairs (80%) intraoperative reduction was lost at an average of 7.0 weeks (range, 3-12 weeks). Four patients (40%) required revision. Subjective patient outcomes included 5 excellent/ good results, 1 fair result, and 4 poor results. Tunnel widening was universally noted, and the failure mode in most patients appeared to be at the holding suture. Conclusion: This transcoracoid, single clavicular tunnel technique was not a reliable approach to CC ligament reconstruction. We noted a high percentage of radiographic redisplacement and clinical failure. This technique, in its current form, cannot be recommended to treat AC joint injuries in our population. Level of evidence: Level IV, Case Series, Treatment Study. (C) 2012 Journal of Shoulder and Elbow Surgery Board of Trustees. C1 [Cook, Jay B.; Shaha, James S.; Rowles, Douglas J.; Bottoni, Craig R.; Tokish, John M.] Tripler Army Med Ctr, Tamc, HI 96859 USA. [Shaha, Steven H.] Univ Utah, Ctr Policy & Publ Adm, Salt Lake City, UT USA. [Shaha, Steven H.] Allscripts, Qual & Outcomes Team, Chicago, IL USA. RP Cook, JB (reprint author), Tripler Army Med Ctr, 1 Jarrett White Rd, Tamc, HI 96859 USA. EM jaybcook@yahoo.com NR 26 TC 21 Z9 21 U1 0 U2 3 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 1058-2746 J9 J SHOULDER ELB SURG JI J. Shoulder Elbow Surg. PD DEC PY 2012 VL 21 IS 12 BP 1746 EP 1752 DI 10.1016/j.jse.2012.01.018 PG 7 WC Orthopedics; Sport Sciences; Surgery SC Orthopedics; Sport Sciences; Surgery GA 062VZ UT WOS:000312953000025 PM 22521387 ER PT J AU Kouri, BE Funaki, BS Ray, CE Abou-Alfa, GK Burke, CT Darcy, MD Fidelman, N Greene, FL Harrison, SA Kinney, TB Kostelic, JK Lorenz, JM Nair, AV Nemcek, AA Owens, CA Saad, WEA Vatakencherry, G AF Kouri, Brian E. Funaki, Brian S. Ray, Charles E., Jr. Abou-Alfa, Ghassan K. Burke, Charles T. Darcy, Michael D. Fidelman, Nicholas Greene, Frederick L. Harrison, Stephen A. Kinney, Thomas B. Kostelic, Jon K. Lorenz, Jonathan M. Nair, Ajit V. Nemcek, Albert A., Jr. Owens, Charles A. Saad, Wael E. A. Vatakencherry, George TI ACR Appropriateness Criteria Radiologic Management of Hepatic Malignancy SO JOURNAL OF THE AMERICAN COLLEGE OF RADIOLOGY LA English DT Article DE Appropriateness criteria; hepatocellular carcinoma; liver metastases; ablation; chemoembolization; radioembolization ID UNRESECTABLE HEPATOCELLULAR-CARCINOMA; COLORECTAL LIVER METASTASES; TRANSCATHETER ARTERIAL CHEMOEMBOLIZATION; RANDOMIZED-CONTROLLED-TRIAL; NEOADJUVANT TRANSARTERIAL CHEMOEMBOLIZATION; PERCUTANEOUS ETHANOL INJECTION; PORTAL-VEIN EMBOLIZATION; RADIOFREQUENCY ABLATION; NEUROENDOCRINE TUMORS; Y-90 MICROSPHERES AB Management of hepatic malignancy is a challenging clinical problem involving several different medical and surgical disciplines. Because of the wide variety of potential therapies, treatment protocols for various malignancies continue to evolve. Consequently, development of appropriate therapeutic algorithms necessitates consideration of medical options, such as systemic chemotherapy; surgical options, such as resection or transplantation; and locoregional therapies, such as thermal ablation and transarterial embolization. The authors discuss treatment strategies for the 3 most common subtypes of hepatic malignancy treated with locoregional therapies: hepatocellular carcinoma, neuroendocrine metastases, and colorectal metastases. The ACR Appropriateness Criteria (R) are evidence-based guidelines for specific clinical conditions that are reviewed every 2 years by a multidisciplinary expert panel. The guideline development and review include an extensive analysis of current medical literature from peer-reviewed journals and the application of a well-established consensus methodology (modified Delphi) to rate the appropriateness of imaging and treatment procedures by the panel. In those instances in which evidence is lacking or not definitive, expert opinion may be used to recommend imaging or treatment. C1 [Kouri, Brian E.] Wake Forest Univ, Baptist Med Ctr, Winston Salem, NC 27109 USA. [Funaki, Brian S.] Univ Chicago, Chicago, IL 60637 USA. [Ray, Charles E., Jr.] Univ Colorado, Denver, CO 80202 USA. [Ray, Charles E., Jr.] Hlth Sci Ctr, Aurora, CO USA. [Abou-Alfa, Ghassan K.] Mem Sloan Kettering Canc Ctr, New York, NY 10021 USA. [Abou-Alfa, Ghassan K.] Cornell Univ, Weill Med Coll, New York, NY 10021 USA. [Abou-Alfa, Ghassan K.] Amer Soc Clin Oncol, Alexandria, VA USA. [Burke, Charles T.] Univ N Carolina Hosp, Chapel Hill, NC USA. [Darcy, Michael D.] Washington Univ, Med Ctr, Mallinckrodt Inst Radiol, St Louis, MO 63110 USA. [Fidelman, Nicholas] Univ Calif San Francisco, San Francisco, CA 94143 USA. [Greene, Frederick L.] Carolinas Med Ctr, Charlotte, NC 28203 USA. [Greene, Frederick L.] Amer Coll Surg, Chicago, IL USA. [Harrison, Stephen A.] Brooke Army Med Ctr, San Antonio, TX USA. [Harrison, Stephen A.] Amer Gastroenterol Assoc, Bethesda, MD USA. [Kinney, Thomas B.] Univ Calif San Diego, Med Ctr, San Diego, CA 92103 USA. [Kostelic, Jon K.] Cent Kentucky Radiol, Lexington, KY USA. [Lorenz, Jonathan M.] Univ Chicago Hosp, Chicago, IL 60637 USA. [Nair, Ajit V.] Kaiser Permanente Modesto Med Ctr, Modesto, CA USA. [Nemcek, Albert A., Jr.] NW Mem Hosp, Chicago, IL 60611 USA. [Owens, Charles A.] Univ Illinois, Coll Med, Chicago, IL USA. [Saad, Wael E. A.] Univ Virginia Hlth Syst, Charlottesville, VA USA. [Vatakencherry, George] Kaiser Permanente Los Angeles Med Ctr, Los Angeles, CA USA. RP Kouri, BE (reprint author), Amer Coll Radiol, 1891 Preston White Dr, Reston, VA 20191 USA. EM bkouri@wakehealth.edu NR 82 TC 2 Z9 2 U1 0 U2 4 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1546-1440 J9 J AM COLL RADIOL JI J. Am. Coll. Radiol. PD DEC PY 2012 VL 9 IS 12 BP 919 EP 925 DI 10.1016/j.jacr.2012.09.002 PG 7 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA 058JK UT WOS:000312629700017 PM 23206650 ER PT J AU Bein, T Zonies, D Philipp, A Zimmermann, M Osborn, EC Allan, PF Nerlich, M Graf, BM Fang, R AF Bein, Thomas Zonies, David Philipp, Alois Zimmermann, Markus Osborn, Erik C. Allan, Patrick F. Nerlich, Michael Graf, Bernhard M. Fang, Raymond TI Transportable extracorporeal lung support for rescue of severe respiratory failure in combat casualties SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY LA English DT Article; Proceedings Paper CT 42nd Annual Meeting of the Western-Trauma-Association CY FEB 26-MAR 03, 2012 CL Vail, CO SP Western Trauma Assoc DE Extracorporeal membrane oxygenation; acute lung injury; adult respiratory distress syndrome; military medicine; transportation of patients ID MEMBRANE-OXYGENATION; DISTRESS-SYNDROME; LIFE-SUPPORT; INJURY; TRAUMA; ASSIST; CARE; ADULTS; SHOCK AB BACKGROUND: Advances in oxygenator membrane, vascular cannula, and centrifugal pump technologies led to the miniaturization of extracorporeal lung support (ECLS) and simplified its insertion and use. Support of combat injuries complicated by severe respiratory failure requires critical care resources not sustainable in the deployed environment. In response to this need, a unique international military-civilian partnership was forged to create a transportable ECLS capability to rescue combat casualties experiencing severe respiratory failure. METHODS: A multidisciplinary training and consultative relationship developed between the US military at Landstuhl Regional Medical Center (LRMC) and the University Hospital Regensburg (UHR), a German regional "lung failure" center with expertise in ECLS. ECLS circuits used were pumpless arteriovenous extracorporeal lung assist (Nova Lung iLA) and pump-driven venovenous extracorporeal membrane oxygenation (PLS Quadrox D Membrane Oxygenator with Rotaflow Centrifugal Pump). US casualties supported by ECLS between June 2005 and August 2011 were identified from the LRMC Trauma Program Registry for review. RESULTS: UHR cared for 10 US casualties supported by ECLS. The initial five patients were cannulated with arteriovenous circuits (pumpless arteriovenous extracorporeal lung assist), and the remaining five were cannulated with pump-driven,venovenous circuits (extracorporeal membrane oxygenation). Four patients were cannulated in the war zone, and six patients were cannulated at LRMC after evacuation to Germany. All patients were transferred to UHR for continued management (mean, 9.6 ECLS days). In all cases, both hypoxemia and hypercapnia improved, allowing for decreased airway pressures. Nine patients were weaned from ECLS and extubated. One soldier died from progressive multiple-organ failure. CONCLUSION: ECLS should be considered in the management of trauma complicated by severe respiratory failure. Modem ECLS technology allows these therapies to be transported for initiation outside of specialized centers even in austere settings. Close collaboration with established centers potentially allows both military and civilian hospitals with infrequent ECLS requirements to use it for initial patient stabilization before transfer for continued care. (J Trauma Acute Care Surg. 2012;73: 1450-1456. Copyright (C) 2012 by Lippincott Williams & Wilkins) LEVEL OF EVIDENCE: Therapeutic/care management study, level V. C1 [Fang, Raymond] USAF, Ctr Sustainment Trauma & Readiness Skills, R Adams Cowley Shock Trauma Ctr, Baltimore, MD USA. [Bein, Thomas; Graf, Bernhard M.] Univ Regensburg, Dept Anaesthesia, Regensburg, Germany. [Philipp, Alois] Univ Regensburg, Dept Cardiothorac & Vasc Surg, Regensburg, Germany. [Nerlich, Michael] Univ Regensburg, Dept Trauma Surg, Regensburg, Germany. [Zimmermann, Markus] Univ Regensburg, Dept Emergency Med, Regensburg, Germany. [Zonies, David] Landstuhl Reg Med Ctr, Dept Trauma & Crit Care, Landstuhl, Germany. [Osborn, Erik C.] Tripler Army Med Ctr, Dept Pulm Med, Honolulu, HI 96859 USA. [Allan, Patrick F.] Wright Patterson AFB Med Ctr, Dept Pulm Med, Wright Patterson AFB, OH USA. RP Fang, R (reprint author), USAF, Ctr Sustainment Trauma & Readiness Skills, R Adams Cowley Shock Trauma Ctr, Baltimore, MD USA. EM Raymond.Fang@wpafb.af.mil NR 25 TC 15 Z9 16 U1 1 U2 17 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 2163-0755 J9 J TRAUMA ACUTE CARE JI J. Trauma Acute Care Surg. PD DEC PY 2012 VL 73 IS 6 BP 1450 EP 1456 DI 10.1097/TA.0b013e3182782480 PG 7 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 058FV UT WOS:000312620400015 PM 23188237 ER PT J AU Dua, A Patel, B Kragh, JF Holcomb, JB Fox, CJ Martin, MJ AF Dua, Anahita Patel, Bhavin Kragh, John F., Jr. Holcomb, John B. Fox, Charles J. Martin, Matthew J. TI Long-term follow-up and amputation-free survival in 497 casualties with combat-related vascular injuries and damage-control resuscitation SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY LA English DT Article; Proceedings Paper CT 42nd Annual Meeting of the Western-Trauma-Association CY FEB 26-MAR 03, 2012 CL Vail, CO SP Western Trauma Assoc DE Vascular trauma; massive transfusion; damage control; resuscitation; combat vascular injury; extremity trauma ID MASSIVE TRANSFUSION; TRAUMA PATIENTS; LOWER-EXTREMITY; BLOOD-PRODUCTS; GLOBAL WAR; BATTLEFIELD; TOURNIQUETS; LAPAROTOMY; VIETNAM; PLASMA AB BACKGROUND: The effectiveness of damage-control resuscitation (DCR) has been demonstrated in recent US conflicts. Wartime casualties treated for hemorrhagic shock from vascular wounds were studied to report the 24-hour transfusion requirements, graft patency, and amputation-free survival for major vascular injuries. METHODS: Joint Theater Trauma Registry data from August 2006 to April 2011 (56 months) were retrospectively reviewed. Included were casualties with a vascular injury who presented to US combat support hospitals in Iraq or Afghanistan. Amputation-free survival and graft patency were determined from record and imaging review. RESULTS: The study group consisted of 497 severely wounded local national and military casualties (mean [SD] Injury Severity Score [ISS], 17 [8.5]) presenting with acidosis (pH 7.29 [0.15]), tachycardia (heart rate, 110 [29.31]), and coagulopathy (international normalized ratio, 1.6 [2.33]). Given DCR and early management of vascular injury, blood pressure, heart rate, temperature, hemoglobin, and base deficit improved promptly (p < 0.05) by intensive care unit admission. Transfusion requirements included packed red blood cells (15 [13] U; range, 1-70 U), fresh frozen plasma (14 [13] U; range, 1-72 U), cryoprecipitate (13 [15] U; range, 1-49 U), and platelets (8 [6] U; range, 1-36 U). Mean operative time was 232 minutes (range, 16-763 minutes). US casualties (n = 111) had limb salvage attempted for 113 extremity vascular injuries (3 [2%] iliac, 33 [30%] femoral, 23 [20%] popliteal, 13 [12%] tibial, 33 [30%] brachial, 4 [3%] ulnar, and 4 [(3%] radial). In this subgroup, 28 (25%) were revascularized by a primary repair or end anastomosis, 80 (71%) were revascularized by saphenovenous grafts, and 5 (4%) were revascularized by prosthetic grafts. The follow-up ranged from 29 days to 1,079 days, (mean, 347 days), during which 96 grafts (84.9%) remained patent, 16 casualties (14.2%) required a delayed amputation, and 110 (99.1%) survived. Popliteal injuries had the highest amputation rate (7 of 23, 30.4%). The amputation-free survival was 84%. CONCLUSION: In severely wounded casualties, wartime surgical strategies to save both life and limb evidently permit definitive procedures at initial surgery with excellent limb salvage results. This outcome analysis in a large cohort can help to refine surgical judgment and support contemporary DCR practices for major vascular injury. (J Trauma Acute Care Surg. 2012;73: 1517-1524. Copyright (C) 2012 by Lippincott Williams & Wilkins) LEVEL OF EVIDENCE: Epidemiologic study, level III; therapeutic study, level V. C1 [Dua, Anahita; Patel, Bhavin] Uniformed Serv Univ Hlth Sci, Dept Surg, Walter Reed Natl Mil Med Ctr, Bethesda, MD 20889 USA. [Fox, Charles J.] Uniformed Serv Univ Hlth Sci, Div Vasc Surg, Walter Reed Natl Mil Med Ctr, Bethesda, MD 20889 USA. [Fox, Charles J.] Uniformed Serv Univ Hlth Sci, Norman M Rich Dept Surg, Bethesda, MD 20889 USA. [Holcomb, John B.] Univ Texas Hlth Sci Ctr, Dept Surg, Div Acute Care Surg, Houston, TX USA. [Kragh, John F., Jr.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Martin, Matthew J.] Madigan Army Med Ctr, Dept Surg, Tacoma, WA 98431 USA. RP Fox, CJ (reprint author), Uniformed Serv Univ Hlth Sci, Dept Surg, Walter Reed Natl Mil Med Ctr, 8901 Rockville Pike, Bethesda, MD 20889 USA. EM foxvascular@gmail.com OI Patel, Bhavin/0000-0002-0877-1067 NR 35 TC 11 Z9 11 U1 0 U2 8 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 2163-0755 J9 J TRAUMA ACUTE CARE JI J. Trauma Acute Care Surg. PD DEC PY 2012 VL 73 IS 6 BP 1517 EP 1524 DI 10.1097/TA.0b013e31827826b7 PG 8 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 058FV UT WOS:000312620400025 PM 23188245 ER PT J AU Blackbourne, LH Baer, DG Eastridge, BJ Butler, FK Wenke, JC Hale, RG Kotwal, RS Brosch, LR Bebarta, VS Knudson, MM Ficke, JR Jenkins, D Holcomb, JB AF Blackbourne, Lorne H. Baer, David G. Eastridge, Brian J. Butler, Frank K. Wenke, Joseph C. Hale, Robert G. Kotwal, Russell S. Brosch, Laura R. Bebarta, Vikhyat S. Knudson, M. Margaret Ficke, James R. Jenkins, Donald Holcomb, John B. TI Military medical revolution: Military trauma system SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY LA English DT Review ID COMBAT CASUALTY CARE; OPERATION-ENDURING-FREEDOM; MAJOR LIMB TRAUMA; FLUID RESUSCITATION; PREVENTABLE DEATH; BATTLEFIELD; WOUNDS; IRAQ; AFGHANISTAN; HEMORRHAGE C1 [Blackbourne, Lorne H.; Baer, David G.; Eastridge, Brian J.; Wenke, Joseph C.; Hale, Robert G.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Bebarta, Vikhyat S.] San Antonio Mil Med Ctr, San Antonio, TX USA. [Ficke, James R.] Brooke Army Med Ctr, MEDCOM, Ft Sam Houston, TX 78234 USA. [Holcomb, John B.] Univ Texas Houston, Hlth Sci Ctr, Houston, TX USA. [Kotwal, Russell S.] Womack Army Med Ctr, MEDCOM, Ft Bragg, NC USA. [Brosch, Laura R.] USA, Med Res & Mat Command, Washington, DC USA. [Knudson, M. Margaret] Univ Calif San Francisco, San Francisco, CA 94143 USA. [Jenkins, Donald] Mayo Clin, Rochester, MN USA. RP Blackbourne, LH (reprint author), USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. EM lorne.h.blackbourne@us.army.mil RI bebarta, vikhyat/K-3476-2015 NR 53 TC 23 Z9 26 U1 0 U2 11 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 2163-0755 EI 2163-0763 J9 J TRAUMA ACUTE CARE JI J. Trauma Acute Care Surg. PD DEC PY 2012 VL 73 SU 5 BP S388 EP S394 DI 10.1097/TA.0b013e31827548df PG 7 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 056QT UT WOS:000312506900004 PM 23192060 ER PT J AU Blackbourne, LH Baer, DG Eastridge, BJ Renz, EM Chung, KK DuBose, J Wenke, JC Cap, AP Biever, KA Mabry, RL Bailey, J Maani, CV Bebarta, V Rasmussen, TE Fang, R Morrison, J Midwinter, MJ Cestero, RF Holcomb, JB AF Blackbourne, Lorne H. Baer, David G. Eastridge, Brian J. Renz, Evan M. Chung, Kevin K. DuBose, Joseph Wenke, Joseph C. Cap, Andrew P. Biever, Kimberlie A. Mabry, Robert L. Bailey, Jeffrey Maani, Christopher V. Bebarta, Vikhyat Rasmussen, Todd E. Fang, Raymond Morrison, Jonathan Midwinter, Mark J. Cestero, Ramon F. Holcomb, John B. TI Military medical revolution: Deployed hospital and en route care SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY LA English DT Review ID TRAUMATIC BRAIN-INJURY; OPERATION IRAQI-FREEDOM; PRESSURE WOUND THERAPY; ENDOVASCULAR BALLOON OCCLUSION; BLOOD-TRANSFUSIONS STRATEGIES; EXTREMITY VASCULAR INJURY; RENAL REPLACEMENT THERAPY; DAMAGE CONTROL SURGERY; ACUTE KIDNEY INJURY; LAST 60 YEARS C1 [Blackbourne, Lorne H.; Baer, David G.; Eastridge, Brian J.; Renz, Evan M.; Chung, Kevin K.; Wenke, Joseph C.; Cap, Andrew P.; Biever, Kimberlie A.; Mabry, Robert L.; Bailey, Jeffrey; Maani, Christopher V.; Rasmussen, Todd E.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Bebarta, Vikhyat] Brooke Army Med Ctr, MEDCOM, Ft Sam Houston, TX 78234 USA. [Cestero, Ramon F.] USN, Naval Med Res Unit San Antonio, San Antonio, TX USA. [Holcomb, John B.] Univ Texas Hlth Sci Ctr Houston, Houston, TX USA. [DuBose, Joseph] Univ Maryland, Med Ctr, Baltimore Ctr Sustainment Trauma & Readiness Skil, Baltimore, MD 21201 USA. [Fang, Raymond] USAF, Landstuhl Reg Med Ctr, Landstuhl, Germany. [Morrison, Jonathan; Midwinter, Mark J.] Royal Ctr Def Med, Birmingham, W Midlands, England. RP Blackbourne, LH (reprint author), USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. EM lorne.h.blackbourne@us.army.mil RI Bailey, John/L-1925-2013; Midwinter, Mark/P-6264-2015; bebarta, vikhyat/K-3476-2015; OI Midwinter, Mark/0000-0003-1836-7137; Morrison, Jonathan/0000-0001-7462-8456 NR 91 TC 17 Z9 17 U1 0 U2 12 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 2163-0755 EI 2163-0763 J9 J TRAUMA ACUTE CARE JI J. Trauma Acute Care Surg. PD DEC PY 2012 VL 73 SU 5 BP S378 EP S387 DI 10.1097/TA.0b013e3182754900 PG 10 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 056QT UT WOS:000312506900003 PM 23192059 ER PT J AU Blackbourne, LH Baer, DG Eastridge, BJ Kheirabadi, B Kragh, JF Cap, AP Dubick, MA Morrison, JJ Midwinter, MJ Butler, FK Kotwal, RS Holcomb, JB AF Blackbourne, Lorne H. Baer, David G. Eastridge, Brian J. Kheirabadi, Bijan Kragh, John F., Jr. Cap, Andrew P. Dubick, Michael A. Morrison, Jonathan J. Midwinter, Mark J. Butler, Frank K. Kotwal, Russell S. Holcomb, John B. TI Military medical revolution: Prehospital combat casualty care SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY LA English DT Review ID EXTREMITY ARTERIAL HEMORRHAGE; 10 HEMOSTATIC DRESSINGS; MAJOR LIMB TRAUMA; GROIN INJURY; LETHAL MODEL; BLOOD-LOSS; SWINE; HYPOTHERMIA; SURVIVAL; AGENT C1 [Blackbourne, Lorne H.; Baer, David G.; Eastridge, Brian J.; Kheirabadi, Bijan; Kragh, John F., Jr.; Cap, Andrew P.; Dubick, Michael A.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Morrison, Jonathan J.; Midwinter, Mark J.] Royal Ctr Def Med, Birmingham, W Midlands, England. [Kotwal, Russell S.] Womack Army Med Ctr, MEDCOM, Ft Bragg, NC USA. [Holcomb, John B.] Univ Texas Houston, Hlth Sci Ctr, Houston, TX USA. RP Blackbourne, LH (reprint author), USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. EM lorne.h.blackbourne@us.army.mil RI Midwinter, Mark/P-6264-2015; OI Midwinter, Mark/0000-0003-1836-7137; Morrison, Jonathan/0000-0001-7462-8456 NR 36 TC 21 Z9 23 U1 1 U2 17 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 2163-0755 EI 2163-0763 J9 J TRAUMA ACUTE CARE JI J. Trauma Acute Care Surg. PD DEC PY 2012 VL 73 SU 5 BP S372 EP S377 DI 10.1097/TA.0b013e3182755662 PG 6 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 056QT UT WOS:000312506900002 PM 23192058 ER PT J AU Blackbourne, LH Baer, DG Rasmussen, TE AF Blackbourne, Lorne H. Baer, David G. Rasmussen, Todd E. TI Advances in combat casualty care: The new historical paradigm with "The World Turned Upside Down" SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY LA English DT Editorial Material C1 [Blackbourne, Lorne H.; Baer, David G.; Rasmussen, Todd E.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Blackbourne, LH (reprint author), USA, Inst Surg Res, 3698 Chambers Pass, Ft Sam Houston, TX 78234 USA. EM lorne.blackboume@amedd.army.mil NR 0 TC 0 Z9 1 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 2163-0755 EI 2163-0763 J9 J TRAUMA ACUTE CARE JI J. Trauma Acute Care Surg. PD DEC PY 2012 VL 73 SU 5 BP S371 EP S371 DI 10.1097/TA.0b013e31827549d2 PG 1 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 056QT UT WOS:000312506900001 PM 23192057 ER PT J AU Borgman, M Matos, RI Blackbourne, LH Spinella, PC AF Borgman, Matthew Matos, Renee I. Blackbourne, Lorne H. Spinella, Philip C. TI Ten years of military pediatric care in Afghanistan and Iraq SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY LA English DT Article DE Pediatrics; trauma; mortality; outcomes ID TRAUMA; MORTALITY; CHILDREN; INJURY AB BACKGROUND: Besides care for injured US military personnel, doctrine also requires life-, limb-, and eyesight-saving care to all injured casualties, including children. This study's objective was to evaluate the burden and epidemiology of pediatric medical care during the past decade of military operations in Iraq and Afghanistan. METHODS: Retrospective review of two military registries of all patients admitted to combat support hospitals and forward surgical teams from 2001 through 2011 was conducted. Pediatric (PED) patients were defined as younger than 18 years. Adult patients were divided into local civilian/noncoalition military (LOCAL) and coalition (COALITION) soldiers. RESULTS: A total of 7,505 PED patients, 25,459 LOCAL adults, and 95,618 COALITION soldiers were analyzed in the primary registry. Children represented 5.8% of all admissions (11% bed days), LOCAL adults represented 20% (36% bed days), and COALITION soldiers represented 74% (53% bed days). PED median (interquartile range) length of stay was 3 days (1-7 days), longer than LOCAL with 2 days (1-6 days), and COALITION with 1 day (1-2 days) (p < 0.001). PED Injury Severity Score (ISS) was 9 (4-16), similar to LOCAL with 9 (4-16) but higher than COALITION with 5 (2-10) (p < 0.001). Mortality in trauma patients was highest in PED (8.5%) compared with LOCAL (7.1%) and COALITION (3%) (p < 0.01). Mechanisms of injury for PED trauma were blast (37%), penetrating (27%), blunt (23%), and burn (13%). Factors independently associated with PED mortality included ISS (odds ratio, 95% confidence interval) (1.08, 1.06-1.09), Glasgow Coma Scale (GCS) score (0.85, 0.82-0.88), base excess (0.87, 0.85-0.90), female sex (1.73, 1.18-2.52), age less than 8 years (1.43, 1.00-2.04), and burns (3.17, 1.89-5.32). CONCLUSION: Deployed medical facilities not staffed or equipped to typical civilian standards have a high burden of pediatric casualties requiring care. The cause of increased mortality in pediatric versus adult populations despite similar severity of injury is potentially multifactorial. Military medical planners need to consider pediatric resources and training to improve outcomes for children injured during combat. (J Trauma Acute Care Surg. 2012;73: S509-S513. Copyright (C) 2012 by Lippincott Williams & Wilkins) C1 [Borgman, Matthew; Matos, Renee I.] Brooke Army Med Ctr, Dept Pediat, San Antonio, TX 78234 USA. [Blackbourne, Lorne H.; Spinella, Philip C.] USA, Inst Surg Res, San Antonio, TX USA. [Spinella, Philip C.] Washington Univ, Dept Pediat, St Louis, MO 63130 USA. RP Borgman, M (reprint author), Brooke Army Med Ctr, Dept Pediat, 3851 Roger Brooke Dr, San Antonio, TX 78234 USA. EM matthew.borgman@us.army.mil RI Borgman, Matthew/L-9477-2015 OI Borgman, Matthew/0000-0002-2008-7380 NR 9 TC 19 Z9 19 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 2163-0755 EI 2163-0763 J9 J TRAUMA ACUTE CARE JI J. Trauma Acute Care Surg. PD DEC PY 2012 VL 73 SU 5 BP S509 EP S513 DI 10.1097/TA.0b013e318275477c PG 5 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 056QT UT WOS:000312506900022 PM 23192078 ER PT J AU Butler, FK Blackbourne, LH AF Butler, Frank K., Jr. Blackbourne, Lorne H. TI Battlefield trauma care then and now: A decade of Tactical Combat Casualty Care SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY LA English DT Review ID MAJOR LIMB TRAUMA; FLUID RESUSCITATION; SPINE IMMOBILIZATION; HEMOSTATIC DRESSINGS; PENETRATING TRAUMA; SPECIAL OPERATIONS; GLOBAL WAR; INJURY; MODEL; TOURNIQUETS C1 [Butler, Frank K., Jr.; Blackbourne, Lorne H.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Butler, FK (reprint author), 4575 Lavallet Ln, Pensacola, FL 32504 USA. EM fkb064@yahoo.com NR 81 TC 46 Z9 48 U1 4 U2 16 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 2163-0755 EI 2163-0763 J9 J TRAUMA ACUTE CARE JI J. Trauma Acute Care Surg. PD DEC PY 2012 VL 73 SU 5 BP S395 EP S402 DI 10.1097/TA.0b013e3182754850 PG 8 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 056QT UT WOS:000312506900005 PM 23192061 ER PT J AU Chan, RK Siller-Jackson, A Verrett, AJ Wu, J Hale, RG AF Chan, Rodney K. Siller-Jackson, Arlene Verrett, Adam J. Wu, Jesse Hale, Robert G. TI Ten years of war: A characterization of craniomaxillofacial injuries incurred during operations Enduring Freedom and Iraqi Freedom SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY LA English DT Article DE Craniomaxillofacial injury; blast injury; explosive devices; ballistic trauma ID AIR MEDICAL EVACUATIONS; ORAL-FACIAL DISEASE; UNITED-STATES; TRAUMA; CASUALTIES; SOLDIERS; FACE AB BACKGROUND: Improved armor and battlefield medicine have led to better survival in the wars in Iraq and Afghanistan than any previous ones. Increased frequency and severity of craniomaxillofacial injuries have been proposed. A comprehensive characterization of the injury pattern sustained during this 10-year period to the craniomaxillofacial region is needed to improve our understanding of these unique injuries, to optimize the treatment for these patients, and to potentially direct strategic development of protective equipment in the future. METHODS: The Joint Theater Trauma Registry was queried from October 19, 2001, to March 27, 2011, covering operations Enduring Freedom and Iraqi Freedom for battle injuries to the craniomaxillofacial region, including patient demographics and mechanism of injury. Injuries were classified according to type (wounds, fractures, burns, vascular injuries, and nerve injuries) using DRG International Classification of Diseases-9th Rev, diagnosis codes. RESULTS: In this 10-year period, craniomaxillofacial battle injuries to the head and neck were found in 42.2% of patients evacuated out of theater. There is a high preponderance of multiple wounds and open fractures in this region. The primary mechanism of injury involved explosive devices, followed by ballistic trauma. CONCLUSION: Modern combat, characterized by blast injuries, results in higher than previously reported incidence of injury to the craniomaxillofacial region. (I Trauma Acute Care Stag. 2012;73: S453-S458. Copyright (C) 2012 by Lippincott Williams & Wilkins) C1 [Chan, Rodney K.; Siller-Jackson, Arlene; Wu, Jesse; Hale, Robert G.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Verrett, Adam J.] Wilford Hall USAF Med Ctr, Div Oral & Maxillofacial Surg, Lackland AFB, TX 78236 USA. RP Chan, RK (reprint author), 3650 Chambers Pass, Ft Sam Houston, TX 78234 USA. EM rodney.k.chan@us.army.mil NR 26 TC 15 Z9 17 U1 1 U2 5 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 2163-0755 EI 2163-0763 J9 J TRAUMA ACUTE CARE JI J. Trauma Acute Care Surg. PD DEC PY 2012 VL 73 SU 5 BP S453 EP S458 DI 10.1097/TA.0b013e3182754868 PG 6 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 056QT UT WOS:000312506900013 PM 23192069 ER PT J AU Eastridge, BJ Mabry, RL Seguin, P Cantrell, J Tops, T Uribe, P Mallett, O Zubko, T Oetjen-Gerdes, L Rasmussen, TE Butler, FK Kotwal, RS Holcomb, JB Wade, C Champion, H Lawnick, M Moores, L Blackbourne, LH AF Eastridge, Brian J. Mabry, Robert L. Seguin, Peter Cantrell, Joyce Tops, Terrill Uribe, Paul Mallett, Olga Zubko, Tamara Oetjen-Gerdes, Lynne Rasmussen, Todd E. Butler, Frank K. Kotwal, Russell S. Holcomb, John B. Wade, Charles Champion, Howard Lawnick, Mimi Moores, Leon Blackbourne, Lorne H. TI Death on the battlefield (2001-2011): Implications for the future of combat casualty care SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY LA English DT Article DE Military; mortality; hemorrhage; prehospital; outcomes ID OPERATION-ENDURING-FREEDOM; UNITED-STATES-ARMY; MAJOR LIMB TRAUMA; TRANEXAMIC ACID; IRAQI-FREEDOM; WOUNDS; INJURY; EXPERIENCE; VIETNAM AB BACKGROUND: Critical evaluation of all aspects of combat casualty care, including mortality, with a special focus on the incidence and causes of potentially preventable deaths among US combat fatalities, is central to identifying gaps in knowledge, training, equipment, and execution of battlefield trauma care. The impetus to produce this analysis was to develop a comprehensive perspective of battlefield death, concentrating on deaths that occurred in the pre-medical treatment facility (pre-MTF) environment. METHODS: The Armed Forces Medical Examiner Service Mortality Surveillance Division was used to identify Operation Iraqi Freedom and Operation Enduring Freedom combat casualties from October 2001 to June 2011 who died from injury in the deployed environment. The autopsy records, perimortem records, photographs on file, and Mortality Trauma Registry of the Armed Forces Medical Examiner Service were used to compile mechanism of injury, cause of injury, medical intervention performed, Abbreviated Injury Scale (AIS) score, and Injury Severity Score (ISS) on all lethal injuries. All data were used by the expert panel for the conduct of the potential for injury survivability assessment of this study. RESULTS: For the study interval between October 2001 and June 2011, 4,596 battlefield fatalities were reviewed and analyzed. The stratification of mortality demonstrated that 87.3% of all injury mortality occurred in the pre-MTF environment. Of the pre-MTF deaths, 75.7% (n = 3,040) were classified as nonsurvivable, and 24.3% (n = 976) were deemed potentially survivable (PS). The injury/physiologic focus of PS acute mortality was largely associated with hemorrhage (90.9%). The site of lethal hemorrhage was truncal (67.3%), followed by junctional (19.2%) and peripheral-extremity (13.5%) hemorrhage. CONCLUSION: Most battlefield casualties died of their injuries before ever reaching a surgeon. As most pre-MTF deaths are nonsurvivable, mitigation strategies to impact outcomes in this population need to be directed toward injury prevention. To significantly impact the outcome of combat casualties with PS injury, strategies must be developed to mitigate hemorrhage and optimize airway management or reduce the time interval between the battlefield point of injury and surgical intervention. Understanding battlefield mortality is a vital component of the military trauma system. Emphasis on this analysis should be placed on trauma system optimization, evidence-based improvements in Tactical Combat Casualty Care guidelines, data-driven research, and development to remediate gaps in care and relevant training and equipment enhancements that will increase the survivability of the fighting force. (J Trauma Acute Care Surg. 2012;73: S431 S437. Copyright (C) 2012 by Lippincott Williams & Wilkins) C1 [Eastridge, Brian J.; Mabry, Robert L.; Rasmussen, Todd E.; Blackbourne, Lorne H.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Seguin, Peter; Cantrell, Joyce; Tops, Terrill; Uribe, Paul; Mallett, Olga; Zubko, Tamara; Butler, Frank K.; Kotwal, Russell S.; Holcomb, John B.; Wade, Charles; Champion, Howard; Lawnick, Mimi; Moores, Leon] Armed Forces Med Examiner Serv, Mortal Surveillance Div, Rockville, MD USA. RP Eastridge, BJ (reprint author), Univ Texas Hlth Sci Ctr San Antonio, 7703 Floyd Curl Dr MC 7740, San Antonio, TX 78229 USA. EM eastridge@uthscsa.edu NR 44 TC 273 Z9 281 U1 12 U2 50 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 2163-0755 EI 2163-0763 J9 J TRAUMA ACUTE CARE JI J. Trauma Acute Care Surg. PD DEC PY 2012 VL 73 SU 5 BP S431 EP S437 DI 10.1097/TA.0b013e3182755dcc PG 7 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 056QT UT WOS:000312506900010 PM 23192066 ER PT J AU Ficke, JR Eastridge, BJ Butler, FK Alvarez, J Brown, T Pasquina, P Stoneman, P Caravalho, J AF Ficke, James R. Eastridge, Brian J. Butler, Frank K. Alvarez, John Brown, Tommy Pasquina, Paul Stoneman, Paul. Caravalho, Joseph, Jr. TI Dismounted complex blast injury report of the army dismounted complex blast injury task force SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY LA English DT Article DE Military; war; explosion; blast; trauma; rehabilitation; outcomes ID COMBAT CASUALTY CARE; TRAUMATIC LIMB LOSS; INITIAL FLUID RESUSCITATION; OPERATION-IRAQI-FREEDOM; PROSTHETIC-DEVICE USE; OIF/OEF CONFLICTS; VIETNAM-WAR; US ARMY; INCREASED MORTALITY; HETASTARCH SOLUTION C1 [Ficke, James R.] San Antonio Mil Med Ctr, San Antonio, TX USA. [Eastridge, Brian J.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Alvarez, John] USA, Med Res & Mat Command, Washington, DC USA. RP Eastridge, BJ (reprint author), Univ Texas Hlth Sci Ctr San Antonio, 7703 Floyd Curl Dr MC 7740, San Antonio, TX 78229 USA. EM eastridge@uthscsa.edu NR 68 TC 12 Z9 12 U1 1 U2 5 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 2163-0755 EI 2163-0763 J9 J TRAUMA ACUTE CARE JI J. Trauma Acute Care Surg. PD DEC PY 2012 VL 73 SU 5 BP S520 EP S534 DI 10.1097/TA.0b013e31827559da PG 15 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 056QT UT WOS:000312506900024 ER PT J AU Glasgow, SC Steele, SR Duncan, JE Rasmussen, TE AF Glasgow, Sean C. Steele, Scott R. Duncan, James E. Rasmussen, Todd E. TI Epidemiology of modern battlefield colorectal trauma: A review of 977 coalition casualties SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY LA English DT Article DE Colon and rectal trauma; fecal diversion; mortality; epidemiology; military ID OPERATION IRAQI FREEDOM; PRIMARY ANASTOMOSIS; COLON INJURIES; ENDURING FREEDOM; PRIMARY REPAIR; MANAGEMENT; DIVERSION; OUTCOMES; WOUNDS; CARE AB BACKGROUND: Traumatic injuries to the lower gastrointestinal tract occur in up to 15% of all injured combatants, with significant morbidity (up to 75%) and mortality. The incidence, etiology, associated injuries, and overall mortality related to modem battlefield colorectal trauma are poorly characterized. METHODS: Using data from the Joint Theater Trauma Registry and other Department of Defense electronic health records, the ongoing Joint Surgical Transcolonic Injury or Ostomy Multi-theater Assessment project quantifies epidemiologie trends in colon injury, risk factors for prolonged or perhaps unnecessary fecal diversion, and quality of life in US military personnel requiring colostomies. In the current study, all coalition troops with colon or rectal injuries as classified by DRG International Classification of Diseases-9th Re v. diagnosis and Abbreviated Injury Scale (AIS) codes in the Joint Theater Trauma Registry were included. RESULTS: During 8 years, 977 coalition military personnel with colorectal injury were identified, with a mean (SD) Injury Severity Score (ISS) of 22.2 (13.2). Gunshot wounds remain the primary mechanism of injury (57.6%). Compared with personnel with colon injuries, those with rectal trauma sustained greater injury to face and extremities but fewer severe thoracic and abdominal injuries (p < 0.005). Overall fecal diversion rates were significantly higher in Iraq than in Afghanistan (38.7% vs. 31.6%, respectively; p = 0.03), predominantly owing to greater use of diversion for colon trauma. There was little difference in diversion rates between theaters for rectal injuries (59.6% vs. 50%, p < 0.15). The overall mortality rate was 8.2%. Notably, the mortality rate for patients with no fecal diversion (10.8%) was significantly greater than those with fecal diversion (3.7%, p < 0.0001). CONCLUSION: Military personnel sustaining colon or rectal trauma continue to have elevated mortality rates, even after reaching surgical treatment facilities. Furthermore, associated serious injuries are commonly encountered. Fecal diversion in these patients may lead to reduced mortality, although prospective selection criteria for diversion do not currently exist. Future research into risk factors for colostomy creation, timing of diversion in relation to damage-control laparotomy, and quality of life in veterans with stomas will produce useful insights and help guide therapy. (J Trauma Acute Care Surg. 2012;73: S503-S508. Copyright 2012 by Lippincott Williams & Wilkins) C1 [Glasgow, Sean C.] San Antonio Mil Med Ctr, Dept Surg, Ft Sam Houston, TX 78234 USA. [Rasmussen, Todd E.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Steele, Scott R.] Madigan Army Med Ctr, Dept Surg, Ft Lewis, WA USA. [Duncan, James E.] Walter Reed Natl Mil Med Ctr, Dept Surg, Bethesda, MD USA. RP Glasgow, SC (reprint author), San Antonio Mil Med Ctr, Dept Surg, 3551 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM sean.glasgow@amedd.army.mil NR 18 TC 12 Z9 12 U1 0 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 2163-0755 EI 2163-0763 J9 J TRAUMA ACUTE CARE JI J. Trauma Acute Care Surg. PD DEC PY 2012 VL 73 SU 5 BP S503 EP S508 DI 10.1097/TA.0b013e3182754759 PG 6 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 056QT UT WOS:000312506900021 PM 23192077 ER PT J AU Ivey, KM White, CE Wallum, TE Aden, JK Cannon, JW Chung, KK McNeil, JD Cohn, SM Blackbourne, LH AF Ivey, Katherine M. White, Christopher E. Wallum, Timothy E. Aden, James K. Cannon, Jeremy W. Chung, Kevin K. McNeil, Jeffrey D. Cohn, Stephen M. Blackbourne, Lorne H. TI Thoracic injuries in US combat casualties: A 10-year review of Operation Enduring Freedom and Iraqi Freedom SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY LA English DT Review DE Thoracic injury; fragmentation injury; tube thoracostomy; Operation Enduring/Iraqi Freedom; US soldiers ID MASSIVE TRANSFUSION; UNITED-STATES; HISTORY; CARE; MANAGEMENT; IMPACT AB BACKGROUND: Mortality from thoracic injuries has declined significantly from 63% in the Civil War to 3% in Vietnam. We reviewed the injury patterns, procedures, blood products, and mortality of US soldiers sustaining a thoracic injury during Operation Enduring Freedom and Iraqi Freedom (OEF/OIF). METHODS: Data on US soldiers with a thoracic injury during OEF/OIF from January 2003 to May 2011 was collected from the Joint Theater Trauma Registry. Coalition forces, civilians, and soldiers killed in action were excluded. Injuries and procedures were identified using DRG International Classification of Diseases-9th Rev. and Abbreviated Injury Scale (AIS) codes. Data are presented as mean (SD). Statistical analysis used chi(2) analysis and (test where appropriate. RESULTS: Thoracic injuries occurred in 2,049 of 23,797 wounded US military personnel for a prevalence of 8.6%. Mean (SD) age was 26 (6.6) years, and mean (SD) chest AIS score was 2.9 (0.9). Penetrating trauma was the most common mechanism of injury (61.5%), and explosive devices were the most common cause of injury (61.9%). Of 6,030 thoracic injuries identified, pneumothorax and pulmonary contusions were most common (51.8% and 50.2%, respectively). Of 1,541 surgical procedures performed in theater, the most common was tube thoracostomy (47.1%). Most patients with penetrating fragmentation injuries (84%) were managed with tube thoracostomy as sole therapeutic intervention. The fresh frozen plasma to packed red blood cells ratio was 0.86. Overall mortality was 8.3%. Acute respiratory distress syndrome and inhalation injury were associated with mortality (p < 0.006). CONCLUSION: Most penetrating fragmentation injuries can be managed with tube thoracostomy. Mortality of patients with chest injury in OEF/OIF is higher than in Korea and Vietnam. This most likely represents advances in prehospital care, personal protective equipment, and rapid transport that have resulted in more severely injured patients arriving alive to a medical facility. (J Trauma Acute Care Surg. 2012;73: S514-S519. Copyright (C) 2012 by Lippincott Williams & Wilkins) C1 [Ivey, Katherine M.; White, Christopher E.; Cannon, Jeremy W.] San Antonio Mil Med Ctr, Dept Gen Surg, Ft Sam Houston, TX 78234 USA. [Wallum, Timothy E.; Aden, James K.; Chung, Kevin K.; Blackbourne, Lorne H.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Cohn, Stephen M.] Univ Texas Hlth Sci Ctr San Antonio, Dept Surg, San Antonio, TX 78229 USA. [Cannon, Jeremy W.] Uniformed Serv Univ Hlth Sci, Dept Surg, Bethesda, MD 20814 USA. RP Ivey, KM (reprint author), San Antonio Mil Med Ctr, Dept Gen Surg, 4241 George C Beach, Ft Sam Houston, TX 78234 USA. EM katherine.ivey@amedd.army.mil NR 25 TC 10 Z9 10 U1 0 U2 7 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 2163-0755 EI 2163-0763 J9 J TRAUMA ACUTE CARE JI J. Trauma Acute Care Surg. PD DEC PY 2012 VL 73 SU 5 BP S514 EP S519 PG 6 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 056QT UT WOS:000312506900023 PM 23192079 ER PT J AU Knudson, MM Rasmussen, TE AF Knudson, M. Margaret Rasmussen, Todd E. TI The Senior Visiting Surgeons program: A model for sustained military-civilian collaboration in times of war and peace SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY LA English DT Article DE Military-civilian collaboration; training; translational research; military trauma system ID CARE; LESSONS C1 [Knudson, M. Margaret] Univ Calif San Francisco, Dept Surg, San Francisco, CA 94110 USA. [Rasmussen, Todd E.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Knudson, MM (reprint author), Univ Calif San Francisco, Dept Surg, 1001 Potrero Ave, San Francisco, CA 94110 USA. EM pknudson@sfghsurg.ucsf.edu NR 14 TC 2 Z9 2 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 2163-0755 EI 2163-0763 J9 J TRAUMA ACUTE CARE JI J. Trauma Acute Care Surg. PD DEC PY 2012 VL 73 SU 5 BP S535 EP S539 DI 10.1097/A.0b013e31827548c9 PG 5 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 056QT UT WOS:000312506900025 ER PT J AU Krueger, CA Wenke, JC Ficke, JR AF Krueger, Chad A. Wenke, Joseph C. Ficke, James R. TI Ten years at war: Comprehensive analysis of amputation trends SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY LA English DT Article DE Extremity amputations; Iraq; Afghanistan; transtibial; transfemoral ID OPERATION ENDURING FREEDOM; TRAUMATIC LIMB LOSS; IRAQI FREEDOM; CURRENT CONFLICTS; EXTREMITY AMPUTATION; OIF/OEF CONFLICTS; RISK-FACTORS; INJURIES; SERVICEMEMBERS; VIETNAM AB BACKGROUND: While multiple studies have examined amputations that have occurred during the current conflicts in Iraq and Afghanistan, none of these studies have provided an overarching characterization of all of these injuries. METHODS: A retrospective study of all major extremity amputations sustained by US Service Members from January 2001 through July 30, 2011, was performed. Data obtained from these amputees included amputation level(s), mechanism of injury, time to amputation, Injury Severity Score (ISS), age, rank, number of trauma admissions, and number of troops deployed. RESULTS: There were 1,221 amputees who met inclusion criteria. These amputees sustained a total of 1,631 amputations. The number of amputations performed each year has increased dramatically in 2010 (196) and the first half of 2011 (160) from 2008 (105) and 2009 (94). The number of amputations performed per every 100 traumatic admissions (3.5-14) and the number of amputations per 100,000 deployed troops (2-14) has also increased in 2010 and the first half of 2011. Most amputations occurred at the transtibial (683, 41.8%) and transfemoral (564, 34.5%) levels. Thirty percent of the amputees (366) sustained multiple amputations, and 14% of all amputations (228) performed involved the upper extremity. There were 127 amputees (10%) who underwent their amputation more than 90 days after the date of injury. CONCLUSION: The number of amputations occurring during the current Iraqi and Afghanistan conflicts has increased in 2010 and the first half of 2011. Most amputations involve the lower extremities, and there is a much higher percentage of amputees who have sustained multiple amputations during current operations than previous conflicts. (J Trauma Acute Care Surg. 2012;73: S438-S444. Copyright (C) 2012 by Lippincott Williams & Wilkins) C1 [Krueger, Chad A.; Ficke, James R.] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. [Wenke, Joseph C.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Krueger, CA (reprint author), Brooke Army Med Ctr, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM chad.krueger@amedd.army.mil NR 36 TC 49 Z9 50 U1 2 U2 19 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 2163-0755 EI 2163-0763 J9 J TRAUMA ACUTE CARE JI J. Trauma Acute Care Surg. PD DEC PY 2012 VL 73 SU 5 BP S438 EP S444 DI 10.1097/TA.0b013e318275469c PG 7 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 056QT UT WOS:000312506900011 PM 23192067 ER PT J AU Morrison, JJ Poon, H Garner, J Midwinter, MJ Jansen, JO AF Morrison, J. J. Poon, H. Garner, J. Midwinter, M. J. Jansen, Jan O. TI Nontherapeutic laparotomy in combat casualties SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY LA English DT Article DE Trauma; military; selective nonoperative management; nontherapeutic laparotomy ID SELECTIVE NONOPERATIVE MANAGEMENT; ABDOMINAL GUNSHOT WOUNDS; TRAUMA; MORBIDITY; STANDARD; STILL AB BACKGROUND: The selective nonoperative management of ballistic abdominal injury remains contentious, particularly in the military setting. The exigencies of military practice have traditionally favored a more liberal approach to abdominal exploration. The driver for selective nonoperative management is the avoidance of morbidity incurred by nontherapeutic intervention. However, the incidence and complications of nontherapeutic laparotomy (NTL) in the military setting are not known. METHODS: All UK military patients undergoing a laparotomy following battlefield trauma were identified from the UK Joint Theatre Trauma Registry. Procedures were classed as therapeutic laparotomy (TL) or NTL. Demographics, admission physiology, injury pattern, and mortality were compared, and complications in the NIL group were determined by Joint Theatre Trauma Registry and case record review. RESULTS: Between March 2003 and March 2011, 130 (7.2%) of 1,813 combat wounded UK service personnel underwent a laparotomy. A total of 103 (79.2%) were considered TL, and 27 (20.8%) were NIL. There was no difference in demographic distribution or mechanism of injury. Patients undergoing TL were more likely to be hypotensive (systolic blood pressure, <90 mm Hg; p = 0.015) and have a reduced consciousness level (Glasgow Coma Scale [GCS] score <= 8; p = 0.006). There was a greater abdominal injury burden in the TL group (p < 0.001). There was no difference in severe extra-abdominal injury (Abbreviated Injury Scale [AIS] score >= 3), overall Injury Severity Score (ISS) and New ISS (NISS) scores, or mortality. Of the 27 patients who underwent NTL, 7 (25.9%) developed complications. CONCLUSION: During the past decade, trauma laparotomy has become a relatively uncommon procedure. The NTL rate is also relatively low. This finding could be explained by the fact that selective nonoperative management is used more widely in the military setting than previously thought or that very few military injuries are amenable to nonoperative management. NIL is associated with a significant risk of complications and should therefore be minimized but not at the expense of missing a life-threatening intra-abdominal injury. (J Trauma Acute Care Surg. 2012;73: S479-S482. Copyright (C) 2012 by Lippincott Williams & Wilkins) C1 [Jansen, Jan O.] Aberdeen Royal Infirm, Aberdeen AB25 2ZN, Scotland. [Morrison, J. J.; Poon, H.; Midwinter, M. J.] Royal Ctr Def Med, Acad Dept Mil Surg & Trauma, Birmingham, W Midlands, England. [Morrison, J. J.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Jansen, JO (reprint author), Aberdeen Royal Infirm, Aberdeen AB25 2ZN, Scotland. EM j.o.jansen@gmx.com RI Midwinter, Mark/P-6264-2015; OI Midwinter, Mark/0000-0003-1836-7137; Morrison, Jonathan/0000-0001-7462-8456 NR 12 TC 4 Z9 4 U1 0 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 2163-0755 EI 2163-0763 J9 J TRAUMA ACUTE CARE JI J. Trauma Acute Care Surg. PD DEC PY 2012 VL 73 SU 5 BP S479 EP S482 DI 10.1097/TA.0b013e318275471f PG 4 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 056QT UT WOS:000312506900017 PM 23192073 ER PT J AU Orman, JA Geyer, D Jones, J Schneider, EB Grafman, J Pugh, MJ DuBose, J AF Orman, Jean A. Geyer, Dennis Jones, John Schneider, Eric B. Grafman, Jordan Pugh, Mary Jo DuBose, Joseph TI Epidemiology of moderate-to-severe penetrating versus closed traumatic brain injury in the Iraq and Afghanistan wars SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY LA English DT Article DE Traumatic and penetrating brain injury; military; epidemiology; Operation Enduring Freedom/Iraqi Freedom; Operation New Dawn ID COMBAT WOUNDS; FREEDOM; HOSPITALIZATIONS; BATTLEFIELD AB BACKGROUND: US combat operations in Iraq and Afghanistan have resulted in a greater proportion of service members with head and neck wounds caused by explosions compared with that of previous wars. Although penetrating traumatic brain injury (TBI) is frequently associated with these wounds, the epidemiology of penetrating TBI from these conflicts has not been well described. METHODS: The Joint Theater Trauma Registry was queried for January 2003 through December 2010 to identify all patients with moderate-to-severe brain injury with a maximum Abbreviated Injury Scale (AIS) score of the head of 3 or greater and a diagnosis of penetrating or closed TBI in accordance with the Department of Defense Traumatic Brain Injury Surveillance definition. The epidemiology of these injuries was examined, including demographics, TBI severity, overall injury severity, and surgical interventions provided. RESULTS: A total of 1,255 TBI patients (774 penetrating, 481 closed) meeting criteria were identified. Penetrating brain injuries were more severe, more likely to be battle related, and less likely to be isolated injuries than a group of moderate-to-severe closed TBIs within the same range of anatomic injury severity. During the 5-year period of the Iraq war with the largest numbers of TBIs (2004-2008), the numbers of penetrating TBIs exceeded closed TBIs by a ratio of 2:1. During the 3-year period of the Afghanistan war with the greatest numbers of TBIs (2008-2010), the ratio of penetrating to closed TBIs was substantially lower, approximately 1.3:1. CONCLUSION: This study represents the first comprehensive report on the epidemiology of moderate-to-severe penetrating and closed TBIs resulting from the wars in Iraq and Afghanistan using Joint Theater Trauma Registry data. With the maturing theater of conflicts, penetrating TBIs were substantially less predominant compared with closed TBIs. While this finding may reflect changes in the use of protective measures and tactics or improvements in diagnosis of closed TBIs, additional research is needed to identify the reason for this shift and the subsequent effect on outcome after combat-related TBIs. (J Trauma Acute Care Surg. 2012;73: S496-S502. Copyright (C) 2012 by Lippincott Williams & Wilkins) C1 [Orman, Jean A.] USA, Inst Surg Res, ATTN MCMR SRR, Ft Sam Houston, TX 78234 USA. [Orman, Jean A.; Pugh, Mary Jo] Univ Texas Hlth Sci Ctr San Antonio, Dept Epidemiol & Biostat, San Antonio, TX 78229 USA. [Geyer, Dennis] San Antonio Mil Med Ctr, Dept Surg, Neurosurg Serv, San Antonio, TX USA. [Pugh, Mary Jo] S Texas Vet Hlth Care Syst, San Antonio, TX USA. [Schneider, Eric B.] Johns Hopkins Sch Med, Ctr Surg Trials & Outcomes Res, Baltimore, MD USA. [DuBose, Joseph] Univ Maryland Med Syst, R Adams Cowley Shock Trauma Ctr, Baltimore, MD USA. [Jones, John] Northwestern Univ, Rehabil Inst Chicago, Chicago, IL 60611 USA. [Grafman, Jordan] Northwestern Univ, Dept Phys Med & Rehabil, Chicago, IL 60611 USA. RP Orman, JA (reprint author), USA, Inst Surg Res, ATTN MCMR SRR, 3698 Chambers Pass, Ft Sam Houston, TX 78234 USA. EM Jean.A.Orman@amedd.army.mil OI Grafman, Jordan H./0000-0001-8645-4457; Pugh, Mary Jo/0000-0003-4196-7763 FU South Texas Veterans Healthcare System FX We acknowledge JTTR for providing data for this study and Ms. Susan West and Ms. Celina Garcia of the JTTR staff for their invaluable assistance in preparing the data set. Some work for this study was supported by resources of the South Texas Veterans Healthcare System. NR 38 TC 8 Z9 9 U1 0 U2 8 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 2163-0755 EI 2163-0763 J9 J TRAUMA ACUTE CARE JI J. Trauma Acute Care Surg. PD DEC PY 2012 VL 73 SU 5 BP S496 EP S502 DI 10.1097/TA.0b013e318275473c PG 7 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 056QT UT WOS:000312506900020 PM 23192076 ER PT J AU Orman, JA Eastridge, BJ Baer, DG Gerhardt, RT Rasmussen, TE Blackbourne, LH AF Orman, Jean A. Eastridge, Brian J. Baer, David G. Gerhardt, Robert T. Rasmussen, Todd E. Blackbourne, Lorne H. TI The impact of 10 years of war on combat casualty care research: A citation analysis SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY LA English DT Review ID OPERATION-ENDURING-FREEDOM; MASSIVE TRANSFUSION; IRAQI-FREEDOM; TRAUMA CENTER; RESUSCITATION; COAGULOPATHY; SURVIVAL; CLASSICS; WOUNDS; INJURY C1 [Orman, Jean A.] USA, Inst Surg Res, ATTN MCMR SRR, Ft Sam Houston, TX 78234 USA. [Orman, Jean A.] Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA. RP Orman, JA (reprint author), USA, Inst Surg Res, ATTN MCMR SRR, 3698 Chambers Pass, Ft Sam Houston, TX 78234 USA. EM Jean.A.Orman@amedd.army.mil NR 28 TC 8 Z9 8 U1 0 U2 7 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 2163-0755 EI 2163-0763 J9 J TRAUMA ACUTE CARE JI J. Trauma Acute Care Surg. PD DEC PY 2012 VL 73 SU 5 BP S403 EP S408 DI 10.1097/TA.0b013e3182754834 PG 6 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 056QT UT WOS:000312506900006 PM 23192062 ER PT J AU Palm, K Apodaca, A Spencer, D Costanzo, G Bailey, J Fortuna, G Blackbourne, LH Spott, MA Eastridge, BJ AF Palm, Keith Apodaca, Amy Spencer, Debra Costanzo, George Bailey, Jeffrey Fortuna, Gerald Blackbourne, Lorne H. Spott, Mary Ann Eastridge, Brian J. TI Evaluation of military trauma system practices related to complications after injury SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY LA English DT Article DE Military; trauma system; complications; outcomes ID VENTILATOR-ASSOCIATED PNEUMONIA; COMBAT CASUALTY CARE; OPERATION ENDURING FREEDOM; IRAQI FREEDOM; AUSTERE ENVIRONMENT; INFECTIONS; PREVENTION; RISK; MANAGEMENT; DISEASE AB BACKGROUND: The Joint Theater Trauma System (JETS) was developed with the vision that every soldier, marine, sailor, and airman injured on the battlefield would have the optimal chance for survival and maximum potential for functional recovery. In this analysis, we hypothesized that injury and complication after injury surveillance information diffusion through the MS, via the dissemination of clinical practice guidelines and process improvements, would be associated with improved combat casualty clinical outcomes. METHODS: The current analysis was designed to profile different aspects of trauma system performance improvement, including monitoring of frequent posttraumatic complications, the assessment of an emerging complication trend, and measurement of the impact of the system interventions to identify potential practices for future performance improvement. Data captured from the Joint Theater Trauma Registry on patients admitted to military medical treatment facilities as a result of wounds incurred in Iraq and Afghanistan from 2003 to 2010 were retrospectively analyzed to determine the potential impact of complication surveillance and process improvement initiatives on clinical practice. RESULTS: Developed metrics demonstrated that the surveillance capacity and evidence-based quality improvement initiatives disseminated through the JTTS were associated with improved identification and mitigation of complications following battlefield injury. CONCLUSION: The Joint Trauma System enables evidence-based practice across the continuum of military trauma care. Concurrent data collection and performance improvement activities at the local and system level facilitate timely clinical intervention on identified trauma complications and the subsequent measurement of the effectiveness of those interventions. (J Trauma Acute Care Surg. 2012;73: S465-S471. Copyright (C) 2012 by Lippincott Williams & Wilkins) C1 [Palm, Keith; Apodaca, Amy; Spencer, Debra; Costanzo, George; Bailey, Jeffrey; Blackbourne, Lorne H.; Spott, Mary Ann; Eastridge, Brian J.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Fortuna, Gerald] Landstuhl Reg Med Ctr, Landstuhl, Germany. RP Eastridge, BJ (reprint author), Univ Texas Hlth Sci Ctr San Antonio, 7703 Floyd Curl Dr MC 7740, San Antonio, TX 78229 USA. EM eastridge@uthscsa.edu NR 40 TC 6 Z9 7 U1 2 U2 8 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 2163-0755 EI 2163-0763 J9 J TRAUMA ACUTE CARE JI J. Trauma Acute Care Surg. PD DEC PY 2012 VL 73 SU 5 BP S465 EP S471 DI 10.1097/TA.0b013e31827548a9 PG 7 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 056QT UT WOS:000312506900015 PM 23192071 ER PT J AU Palm, K Apodaca, A Spencer, D Costanzo, G Bailey, J Blackbourne, LH Spott, MA Eastridge, BJ AF Palm, Keith Apodaca, Amy Spencer, Debra Costanzo, George Bailey, Jeffrey Blackbourne, Lorne H. Spott, Mary Ann Eastridge, Brian J. TI Evaluation of military trauma system practices related to damage-control resuscitation SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY LA English DT Article DE Military; trauma system; performance improvement; resuscitation; outcomes ID COMBAT CASUALTY CARE; OPERATION ENDURING FREEDOM; MASSIVE TRANSFUSION; HYPOTHERMIA; COAGULOPATHY; BLOOD; THEATER; IMPACT; WAR AB BACKGROUND: The Joint Theater Trauma System (JTTS) was developed with the vision that every soldier, marine, sailor, and airman injured on the battlefield would have the optimal chance for survival and maximum potential for functional recovery. In this analysis, we hypothesized that information diffusion through the JTTS, via the dissemination of clinical practice guidelines and process improvements, would be associated with the acceptance of evidence-based practices and decreases in trauma practice variability. METHODS: The current evaluation was designed as a single time-series quasi-experimental study as a preanalysis and postanalysis relative to the implementation of clinical practice guidelines and process improvement interventions. Data captured from patients admitted to hospital-level (Level III) military treatment facilities in Iraq and Afghanistan from 2003 to 2010 were retrospectively analyzed from the Joint Theater Trauma Registry (JTTR) to determine the potential impact of process improvement initiatives on clinical practice. RESULTS: The TITS clinical practice guidelines for massive transfusion led to increased compliance with balanced component transfusion and decreased practice variability. During the course of the evaluation period, hypothermia on presentation decreased dramatically after the publication of the hypothermia prevention and management clinical practice guideline. CONCLUSION: Developed metrics demonstrate that evidence-based quality improvement initiatives disseminated through the JTTS were associated with improved clinical practice of resuscitation following battlefield injury. (I Trauma Acute Care Surg. 2012;73: S459-S464. Copyright (C) 2012 by Lippincott Williams & Wilkins) C1 [Palm, Keith; Apodaca, Amy; Spencer, Debra; Costanzo, George; Bailey, Jeffrey; Blackbourne, Lorne H.; Spott, Mary Ann; Eastridge, Brian J.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Eastridge, BJ (reprint author), Univ Texas Hlth Sci Ctr San Antonio, 7703 Floyd Curl Dr MC 7740, San Antonio, TX 78229 USA. EM eastridge@uthscsa.edu NR 41 TC 12 Z9 14 U1 0 U2 4 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 2163-0755 EI 2163-0763 J9 J TRAUMA ACUTE CARE JI J. Trauma Acute Care Surg. PD DEC PY 2012 VL 73 SU 5 BP S459 EP S464 DI 10.1097/TA.0b013e3182754887 PG 6 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 056QT UT WOS:000312506900014 PM 23192070 ER PT J AU Pidcoke, HF Aden, JK Mora, AG Borgman, MA Spinella, PC Dubick, MA Blackbourne, LH Cap, AP AF Pidcoke, Heather F. Aden, James K. Mora, Alejandra G. Borgman, Matthew A. Spinella, Philip C. Dubick, Michael A. Blackbourne, Lorne H. Cap, Andrew P. TI Ten-year analysis of transfusion in Operation Iraqi Freedom and Operation Enduring Freedom: Increased plasma and platelet use correlates with improved survival SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY LA English DT Article DE Transfusion ratio; coagulopathy; massive transfusion; OIF; OEF ID ACUTE TRAUMATIC COAGULOPATHY; DAMAGE CONTROL RESUSCITATION; COMBAT CASUALTIES; BLOOD; MORTALITY; IMPACT AB BACKGROUND: The Joint Theater Trauma Registry database, begun early in Operation Iraqi Freedom and Operation Enduring Freedom, created a comprehensive repository of information that facilitated research efforts and produced rapid changes in clinical care. New clinical practice guidelines were adopted throughout the last decade. The damage-control resuscitation clinical practice guideline sought to provide high-quality blood products in support of tissue perfusion and hemostasis. The goal was to reduce death from hemorrhagic shock in patients with severe traumatic bleeding. This 10-year review of the Joint Theater Trauma Registry database reports the military's experience with resuscitation and coagulopathy, evaluates the effect of increased plasma and platelet (PLT) to red blood cell ratios, and analyzes other recent changes in practice. METHODS: Records of US active duty service members at least 18 years of age who were admitted to a military hospital from March 2003 to February 2012 were entered into a database. Those who received at least one blood product (n = 3,632) were included in the analysis. Data were analyzed with respect to interactions within and between categories (demographics, admission characteristics, hospital course, and outcome). Transfusions were analyzed with respect to time, survival, and effect of increasing transfusion ratios. RESULTS: Coagulopathy was prevalent upon presentation (33% with international normalized ratio >= 1.5), correlated with increased mortality (fivefold higher), and was associated with the need for massive transfusion. High transfusion ratios of fresh frozen plasma and PLT to red blood cells were correlated with higher survival but not decreased blood requirement. Survival was most correlated with PLT ratio, but high fresh frozen plasma ratio had an additive effect (PLT odds ratio, 0.22). CONCLUSION: This 10-year evaluation supports earlier studies reporting the benefits of damage-control resuscitation strategies in military casualties requiring massive transfusion. The current analysis suggests that defects in PLT function may contribute to coagulopathy of trauma. (J Traunta Acute Care Surg. 2012;73: S445-S452. Copyright (C) 2012 by Lippincott Williams & Wilkins) C1 [Pidcoke, Heather F.; Aden, James K.; Mora, Alejandra G.; Borgman, Matthew A.; Spinella, Philip C.; Dubick, Michael A.; Blackbourne, Lorne H.; Cap, Andrew P.] USA, Inst Surg Res, Brooke Anny Med Ctr, Ft Sam Houston, TX 78234 USA. [Spinella, Philip C.] Washington Univ, Dept Pediat, St Louis, MO 63130 USA. RP Cap, AP (reprint author), USA, Inst Surg Res, 3400 Rawley E Chambers Ave, Ft Sam Houston, TX 78234 USA. EM ANDRE.P.CAP@US.ARMY.MIL RI Borgman, Matthew/L-9477-2015 OI Borgman, Matthew/0000-0002-2008-7380 NR 24 TC 55 Z9 55 U1 0 U2 4 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 2163-0755 EI 2163-0763 J9 J TRAUMA ACUTE CARE JI J. Trauma Acute Care Surg. PD DEC PY 2012 VL 73 SU 5 BP S445 EP S452 DI 10.1097/TA.0b013e3182754796 PG 8 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 056QT UT WOS:000312506900012 PM 23192068 ER PT J AU Rentas, F Lincoln, D Harding, A Maas, P Giglio, J Fryar, R Elder, K Fahie, R Whitlock, K Vinluan, J Gonzales, R AF Rentas, Francisco Lincoln, David Harding, Aaron Maas, Peter Giglio, Joseph Fryar, Ronny Elder, Kathleen Fahie, Roland Whitlock, Kathleen Vinluan, Jerome Gonzales, Richard TI The Armed Services Blood Program: Blood support to combat casualty care 2001 to 2011 SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY LA English DT Article DE Armed Services; combat; transfusion; blood components ID I TRAUMA CENTER; CELL STORAGE; SEVERE INJURY; STORED-BLOOD; OLD BLOOD; DEATHS; EPIDEMIOLOGY; TRANSFUSION; MORTALITY; RESUSCITATION AB BACKGROUND: The Armed Services Blood Program (ASBP) provides the farthest-reaching blood supply in the world. This article provides statistics and a review of blood operations in support of combat casualty care during the last 10 years. It also outlines changes in blood doctrine in support of combat casualty care. METHODS: This is a descriptive overview and review of blood product use and transfusions used by ASBP personnel to support combat operations in Iraq and Afghanistan between October 2001 and November 2011. RESULTS: The ASBP initiated major changes in blood availability and age of blood in theater. In support of data published by physicians in theater, showing improved patient survival when a higher ratio of fresh frozen plasma and red blood cells (RBCs) is achieved, plus the use of platelets, the ASBP increased availability of plasma and established platelet collection facilities in theater. New capabilities included emergency collection of apheresis platelets in the battlefield, availability and transfusion of deglycerolized red cells, rapid diagnostic donor screening, and a new modular blood detachment. Forward surgical facilities that were at one time limited to a blood inventory consisting of RBCs now have a complete arsenal of products at their fingertips that may include fresher RBCs, fresh frozen plasma, cryoprecipitate, and platelets. A number of clinical practice guidelines are in place to address these processes. Changes in blood doctrine were made to support new combat casualty care and damage-control resuscitation initiatives. CONCLUSION: Despite the challenges of war in two theaters of operation, a number of improvements and changes to blood policy have been developed during the last 10 years to support combat casualty care. The nature of medical care in combat operations will continue to be dynamic and constantly evolving. The ASBP needs to be prepared to meet future challenges. (J Trauma Acute Care Surg. 2012;73: S472-S478. Copyright (C) 2012 by Lippincott Williams & Wilkins) C1 [Rentas, Francisco; Lincoln, David; Harding, Aaron; Maas, Peter] Armed Serv Blood Program Off, Falls Church, VA 22041 USA. [Fryar, Ronny; Elder, Kathleen] Army Blood Program, Falls Church, VA USA. [Fahie, Roland; Whitlock, Kathleen] USN, Blood Program, Washington, DC USA. [Vinluan, Jerome] Armed Serv Whole Blood Proc Lab, Mcguire AFB, NJ USA. [Gonzales, Richard] USA, Med Mat Dev Act, Ft Detrick, MD USA. RP Rentas, F (reprint author), Armed Serv Blood Program Off, 5109 Leesburg Pike,Suite 698, Falls Church, VA 22041 USA. EM frank.rentas@us.army.mil NR 32 TC 2 Z9 3 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 2163-0755 EI 2163-0763 J9 J TRAUMA ACUTE CARE JI J. Trauma Acute Care Surg. PD DEC PY 2012 VL 73 SU 5 BP S472 EP S478 DI 10.1097/TA.0b013e31827546e4 PG 7 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 056QT UT WOS:000312506900016 PM 23192072 ER PT J AU Renz, EM King, BT Chung, KK White, CE Lundy, JB Lairet, KF Maani, CF Young, AW Stout, LR Chan, RK Wolf, SE Baer, DG Cancio, LC Blackbourne, LH AF Renz, Evan M. King, Booker T. Chung, Kevin K. White, Christopher E. Lundy, Jonathan B. Lairet, Kimberly F. Maani, Christopher F. Young, Alan W. Stout, Louis R. Chan, Rodney K. Wolf, Steven E. Baer, David G. Cancio, Leopoldo C. Blackbourne, Lorne H. TI The US Army burn center: Professional service during 10 years of war SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY LA English DT Review ID OPERATION IRAQI FREEDOM; ACUTE KIDNEY INJURY; MILITARY CASUALTIES; COMBAT CASUALTIES; ENDURING FREEDOM; HAND BURNS; RESUSCITATION; MANAGEMENT; FLUID; SUPPORT C1 [Renz, Evan M.; King, Booker T.; Chung, Kevin K.; White, Christopher E.; Lundy, Jonathan B.; Lairet, Kimberly F.; Maani, Christopher F.; Stout, Louis R.; Chan, Rodney K.; Baer, David G.; Cancio, Leopoldo C.; Blackbourne, Lorne H.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Wolf, Steven E.] Univ Texas SW, Dallas, TX USA. [Renz, Evan M.; Chung, Kevin K.; Maani, Christopher F.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. RP Renz, EM (reprint author), USA, Inst Surg Res, 3698 Chambers Pass, Ft Sam Houston, TX 78234 USA. EM Evan.Renz@amedd.army.mil OI Wolf, Steven/0000-0003-2972-3440 NR 49 TC 3 Z9 3 U1 0 U2 4 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 2163-0755 EI 2163-0763 J9 J TRAUMA ACUTE CARE JI J. Trauma Acute Care Surg. PD DEC PY 2012 VL 73 SU 5 BP S409 EP S416 DI 10.1097/TA.0b013e318275499f PG 8 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 056QT UT WOS:000312506900007 PM 23192063 ER PT J AU Wedmore, IS Kotwal, RS McManus, JG Pennardt, A Talbot, TS Fowler, M McGhee, L AF Wedmore, Ian S. Kotwal, Russ S. McManus, John G. Pennardt, Andre Talbot, Timothy S. Fowler, Marcie McGhee, Laura TI Safety and efficacy of oral transmucosal fentanyl citrate for prehospital pain control on the battlefield SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY LA English DT Article DE Acute pain; prehospital analgesia; battlefield; oral transmucosal fentanyl citrate; pain management ID BREAKTHROUGH CANCER PAIN; COMBAT CASUALTY CARE; RANDOMIZED CLINICAL-TRIAL; INTRAVENOUS MORPHINE; EMERGENCY-MEDICINE; OPEN-LABEL; POSTOPERATIVE PAIN; LACERATION REPAIR; CASE SERIES; MANAGEMENT AB BACKGROUND: Acute pain, resulting from trauma and other causes, is a common condition that imposes a need for prehospital analgesia on and off the battlefield. The narcotic most frequently used for prehospital analgesia on the battlefield during the past century has been morphine. Intramuscular morphine has a delayed onset of pain relief that is suboptimal and difficult to titrate. Although intravenously administered morphine can readily provide rapid and effective prehospital analgesia, oral transmucosal fentanyl citrate (OTFC) is a safe alternative that does not require intravenous access. This study evaluates the safety and efficacy of OTFC in the prehospital battlefield environment. METHODS: Data collected during combat deployments (Afghanistan and Iraq) from March 15, 2003, to March 31, 2010, were analyzed. Patients were US Army Special Operations Command casualties. Patients receiving OTFC for acute pain were evaluated. Pretreatment and posttreatment pain intensities were quantified by the verbal numeric rating scale (NRS) from 0 to 10. OTFC adverse effects and injuries treated were also evaluated. RESULTS: A total of 286 patients were administered OTFC, of whom 197 had NRS pain evaluations conducted before and approximately 15 minutes to 30 minutes following treatment. The difference between NRS pain scores at 0 minutes (NRS, 8.0 [1.4]) and 15 minutes to 30 minutes (NRS, 3.2 [2.1]) was significant (p < 0.001). Only 18.3% (36 of 197) of patients were also administered other types of analgesics. Nausea was the most common adverse effect as reported by 12.7% (25 of 197) of patients. The only major adverse effect occurred in the patient who received the largest opioid dose, 3,200-mu g OTFC and 20-mg morphine. This patient exhibited hypoventilation and saturation of less than 90% requiring low-dose naloxone. CONCLUSION: OTFC is a rapid and noninvasive pain management strategy that provides safe and effective analgesia in the prehospital battlefield setting. OTFC has considerable implications for use in civilian prehospital and austere environments. (J Trauma Acute Care Surg. 2012;73: S490-S495. Copyright (C) 2012 by Lippincott Williams & Wilkins) C1 [Kotwal, Russ S.; Pennardt, Andre; Talbot, Timothy S.] USA, Special Operat Command, Ft Bragg, NC 28310 USA. [Wedmore, Ian S.] Joint Base Lewis McChord, Madigan Army Med Ctr, Washington, DC USA. [McManus, John G.] Army Med Dept Ctr & Sch, Emergency Med Serv, Ft Sam Houston, TX USA. [Fowler, Marcie; McGhee, Laura] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Kotwal, RS (reprint author), USA, Special Operat Command, 2929 Desert Storm Dr, Ft Bragg, NC 28310 USA. EM russ.kotwal@us.army.mil NR 50 TC 15 Z9 15 U1 1 U2 10 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 2163-0755 EI 2163-0763 J9 J TRAUMA ACUTE CARE JI J. Trauma Acute Care Surg. PD DEC PY 2012 VL 73 SU 5 BP S490 EP S495 DI 10.1097/TA.0b013e3182754674 PG 6 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 056QT UT WOS:000312506900019 PM 23192075 ER PT J AU Furtado, MD Rossetti, F Chanda, S Yourick, D AF Furtado, Marcio de Araujo Rossetti, Franco Chanda, Soma Yourick, Debra TI Exposure to nerve agents: From status epilepticus to neuroinflammation, brain damage, neurogenesis and epilepsy SO NEUROTOXICOLOGY LA English DT Article DE Nerve agents; Status epilepticus; Spontaneous recurrent seizures; Epileptogenesis; Neurogenesis ID SOMAN-INDUCED SEIZURES; TEMPORAL-LOBE EPILEPSY; SPONTANEOUS RECURRENT SEIZURES; CONVULSIVE STATUS EPILEPTICUS; SPRAGUE-DAWLEY RATS; SARIN-INDUCED SEIZURES; CA3 PYRAMIDAL CELLS; CYCLOOXYGENASE-2 INHIBITOR; GUINEA-PIGS; KAINIC ACID AB Epilepsy is a common neurological disorder characterized by an initial injury due to stroke, traumatic brain injury, brain infection, or febrile seizures causing status epilepticus (SE). This phenomenon precedes recurrent (secondary) seizures, the latent period (period without seizures) and downstream appearance of spontaneous recurrent seizures (SRS). Epilepsy inducers include the organophosphorous (OP) compounds modified as chemical warfare nerve agents, such as soman. SE induced by soman is a result of cholinergic system hyperactivity caused by the irreversible inhibition of acetylcholinesterase, and the subsequent increase in the amount of the neurotransmitter acetylcholine at central and peripheral sites. SE leads to profound, permanent, complex and widespread brain damage and associated cognitive and behavioral deficits, accompanied by impaired neurogenesis. Several anticonvulsant and neuroprotective strategies have been studied in order to avoid the epileptogenesis which occurs after SE caused by soman exposure. In recent studies, we showed that SRS occur post-soman exposure and neuropathology can be reduced with diazepam (DZP) and valproic acid (VPA) when administered in combination treatment. These effects are accompanied by neurogenesis seen 15 days post-exposure in the hippocampal dentate gyrus (DG). This review discusses several findings about epilepsy induced by soman exposure such as behavioral changes, EEG anomalies, neuropathology, neuroinflammation, neurogenesis, possible circuitry changes and current strategies for treatment. The soman seizure model is an important model of temporal lobe epilepsy (TLE) and comparable in certain respects with well studied models in the literature such as pilocarpine and kainic acid. All these models together allow for a greater understanding of the different mechanisms of seizure induction, propagation and options for treatment. These studies are very necessary for current military and civilian treatment regimens, against OP nerve agent exposure, which fail to prevent SE resulting in severe neuropathology and epilepsy. Published by Elsevier Inc. C1 [Yourick, Debra] Walter Reed Army Inst Res, US Army Garrison Forest Glen, Ctr Mil Psychiat & Neurosci, Blast Induced Neurotrauma Branch, Silver Spring, MD 20910 USA. RP Yourick, D (reprint author), Walter Reed Army Inst Res, US Army Garrison Forest Glen, Ctr Mil Psychiat & Neurosci, Blast Induced Neurotrauma Branch, 2460 Linden Lane,Bldg 503, Silver Spring, MD 20910 USA. EM debra.yourick@us.army.mil RI Yourick, Debra/A-2121-2011 FU National Research Council; Defense Threat Reduction Agency [I.E0042-08-WR-C] FX Dr. Marcio de Araujo Furtado is currently employed by Clinical RM, Inc., and under contract to the Walter Reed Army Institute of Research. Dr. Franco Rossetti is supported administratively by a National Research Council fellowship. The present study was supported financially by the Defense Threat Reduction Agency (Grant I.E0042-08-WR-C, Principal Investigator: Dr. Debra Yourick). NR 219 TC 14 Z9 15 U1 1 U2 115 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0161-813X J9 NEUROTOXICOLOGY JI Neurotoxicology PD DEC PY 2012 VL 33 IS 6 SI SI BP 1476 EP 1490 DI 10.1016/j.neuro.2012.09.001 PG 15 WC Neurosciences; Pharmacology & Pharmacy; Toxicology SC Neurosciences & Neurology; Pharmacology & Pharmacy; Toxicology GA 063UI UT WOS:000313027100011 ER PT J AU Kranz, M Allen, MG Hudson, T AF Kranz, M. Allen, M. G. Hudson, T. TI In situ wafer-level polarization of electret films in MEMS acoustic sensor arrays SO SENSORS AND ACTUATORS A-PHYSICAL LA English DT Article; Proceedings Paper CT 16th International Conference On Solid-State Sensors, Actuators and Microsystems CY JUN 05-09, 2011 CL Beijing, PEOPLES R CHINA DE Microplasma; Microcorona; Electret; Ultrasonic; Acoustic; Vibration AB Polymer electrets, polymers with a quasi-permanent electrostatic polarization, are commonly employed in a macro-scale form factor within transducers such as the electret condenser microphone. In addition, MEMS-based electret transduction has been reported for both acoustic sensors and energy harvesters. In these micro-devices, the polymer film is typically polarized prior to assembly into the device. Common techniques employed in MEMS electret polarization include corona discharge and backlighted thyratron. with wafer-bonding and simple stacked assemblies being employed to perform the actual assembly and integration. In contrast, this paper reports a method for post-release in situ polarization of electret films within a MEMS device. The method utilizes microplasma discharges with self-aligned charging grids integrated within the device to charge fluoropolymer films in a fashion similar to the corona discharge technique. This in situ approach enables the integration of uncharged electret films into MEMS and subsequent post-fabrication charging, simultaneously enabling the formation of buried or encapsulated electrets as well as eliminating the need to restrict fabrication processes that might otherwise discharge pre-charged electret materials. The method is applied to a single-chip array of ultrasonic sensors designed to capture and analyze waveforms from impacts. (C) 2011 Elsevier B.V. All rights reserved. C1 [Allen, M. G.] Georgia Inst Technol, Microelect Res Ctr, Atlanta, GA 30332 USA. [Hudson, T.] USA, Aviat & Missile Res Dev & Engn Ctr, RDMR WSI, Redstone Arsenal, AL 35898 USA. [Kranz, M.] Morgan Res Corp, MEMS Nanotechnol & Fiber Opt, Huntsville, AL USA. RP Kranz, M (reprint author), 26184 Mooresville Rd, Elkmont, AL 35620 USA. EM michaelskranz@gmail.com NR 13 TC 4 Z9 4 U1 0 U2 35 PU ELSEVIER SCIENCE SA PI LAUSANNE PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND SN 0924-4247 J9 SENSOR ACTUAT A-PHYS JI Sens. Actuator A-Phys. PD DEC PY 2012 VL 188 SI SI BP 181 EP 189 DI 10.1016/j.sna.2011.11.039 PG 9 WC Engineering, Electrical & Electronic; Instruments & Instrumentation SC Engineering; Instruments & Instrumentation GA 059GN UT WOS:000312692500025 ER PT J AU Smith, GL Rudy, RQ Polcawich, RG Devoe, DL AF Smith, Gabriel L. Rudy, Ryan Q. Polcawich, Ronald G. DeVoe, Don L. TI Integrated thin-film piezoelectric traveling wave ultrasonic motors SO SENSORS AND ACTUATORS A-PHYSICAL LA English DT Article; Proceedings Paper CT 16th International Conference On Solid-State Sensors, Actuators and Microsystems CY JUN 05-09, 2011 CL Beijing, PEOPLES R CHINA DE Piezoelectric; PZT; MEMS; Ultrasonic; Motor AB An integrated approach to the fabrication of thin-film piezoelectric traveling wave ultrasonic motors at the mm-scale is being developed for low power, high torque motors for small scale robotics, biomedical, and sensing applications. This paper describes the realization of ultrasonic motor stators ranging in diameter from 1 to 3 mm using wafer scale MEMS fabrication techniques with lead zirconate titanate (PZT) thin films. Using laser Doppler vibrometry (LDV), controlled traveling waves were demonstrated in the bulk silicon elastic medium of the stator and the standing wave behavior was characterized for control purposes. Furthermore, the resonant modes of the fabricated stators were modeled using finite element models, and experimental results agree well with this analysis. (C) 2011 Elsevier B.V. All rights reserved. C1 [Smith, Gabriel L.; Rudy, Ryan Q.; Polcawich, Ronald G.] USA, Res Lab, Adelphi, MD 20783 USA. [Rudy, Ryan Q.; DeVoe, Don L.] Univ Maryland, Park, MD USA. [Smith, Gabriel L.] USA, Armaments Res Dev & Engn Ctr, Adelphi, MD USA. RP Rudy, RQ (reprint author), USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM ryan.q.rudy.ctr@mail.mil RI DeVoe, Don/A-2891-2011 OI DeVoe, Don/0000-0002-7740-9993 NR 8 TC 10 Z9 10 U1 10 U2 58 PU ELSEVIER SCIENCE SA PI LAUSANNE PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND SN 0924-4247 J9 SENSOR ACTUAT A-PHYS JI Sens. Actuator A-Phys. PD DEC PY 2012 VL 188 SI SI BP 305 EP 311 DI 10.1016/j.sna.2011.12.029 PG 7 WC Engineering, Electrical & Electronic; Instruments & Instrumentation SC Engineering; Instruments & Instrumentation GA 059GN UT WOS:000312692500041 ER PT J AU Kamkar, SJ Wissink, AM Sankaran, V Jameson, A AF Kamkar, S. J. Wissink, A. M. Sankaran, V. Jameson, A. TI Combined Feature-Driven Richardson-Based Adaptive Mesh Refinement for Unsteady Vortical Flows SO AIAA JOURNAL LA English DT Article; Proceedings Paper CT 49th AIAA Aerospace Sciences Meeting Including the New Horizons Forum and Aerospace Exposition CY JAN 03-07, 2011 CL Orlando, FL SP AIAA ID STRUCTURED AMR; VORTEX; SHOCK AB An adaptive mesh refinement strategy that couples feature detection with local error estimation is presented. The strategy first selects vortical regions for refinement using feature detection, and then terminates refinement when an acceptable error level has been reached. The feature detection scheme uses a local normalization of the Q-criterion, which allows it to properly identify regions of swirling flow without requiring case-specific tuning. The error estimator relies upon a Richardson extrapolation-like procedure to compute local solution error by comparing the solution on different grid levels. Validation of the proposed approach is carried out using a theoretical advecting vortex and two practical cases, namely, tip vortices from a NACA 0015 wing and the wake structure of a quarter-scale V22 rotor in hover. C1 [Kamkar, S. J.; Wissink, A. M.; Sankaran, V.] USA, Aeroflightdynam Directorate, Moffett Field, CA 94035 USA. [Jameson, A.] Stanford Univ, Stanford, CA 94305 USA. RP Kamkar, SJ (reprint author), USA, Aeroflightdynam Directorate, Moffett Field, CA 94035 USA. EM skamkar@merlin.arc.nasa.gov; andrew.m.wissink@us.army.mil; vsankaran@merlin.arc.nasa.gov; jameson@baboon.stanford.edu NR 41 TC 4 Z9 4 U1 0 U2 1 PU AMER INST AERONAUTICS ASTRONAUTICS PI RESTON PA 1801 ALEXANDER BELL DRIVE, STE 500, RESTON, VA 22091-4344 USA SN 0001-1452 EI 1533-385X J9 AIAA J JI AIAA J. PD DEC PY 2012 VL 50 IS 12 BP 2834 EP 2847 DI 10.2514/1.J051679 PG 14 WC Engineering, Aerospace SC Engineering GA 055QK UT WOS:000312431300017 ER PT J AU Holm, JD Granet, JJ Schlindwein, PA Jacoby, KM Hoffman, LL AF Holm, John D. Granet, Jesse J. Schlindwein, Paul Alan Jacoby, Karin M. Hoffman, Lynda L. TI Turning the Blue River Green SO CIVIL ENGINEERING LA English DT Article C1 [Holm, John D.] USA, Corps Engineers, Civil Branch, Kansas City, MO 64106 USA. [Granet, Jesse J.; Schlindwein, Paul Alan; Jacoby, Karin M.] Spice Consulting LLC, Kansas City, MO USA. [Hoffman, Lynda L.] Water Serv Dept City Kansas City, Kansas City, MO USA. RP Holm, JD (reprint author), USA, Corps Engineers, Civil Branch, Kansas City, MO 64106 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 0885-7024 J9 CIVIL ENG JI Civil Eng. PD DEC PY 2012 VL 82 IS 12 BP 72 EP + PG 7 WC Engineering, Civil SC Engineering GA 056CU UT WOS:000312466800015 ER PT J AU Bebarta, V Vargas, T AF Bebarta, Vikhyat Vargas, Toni TI EVALUATION OF EXTREMITY TISSUE AND BONE INJURY AFTER INTRAOSSEOUS HYPERTONIC SALINE INFUSION IN PROXIMAL TIBIA AND PROXIMAL HUMERUS IN ADULT SWINE (SUS SCROFA) SO CRITICAL CARE MEDICINE LA English DT Meeting Abstract CT 42nd Critical Care Congress of the Society-of-Critical-Care-Medicine CY JAN 19-23, 2013 CL San Juan, PR SP Soc Crit Care Medi C1 [Bebarta, Vikhyat] USA, San Antonio Mil Med Ctr, ISR, Rockville, MD USA. RI Bebarta, Vikhyat/M-1513-2015; bebarta, vikhyat/K-3476-2015 NR 0 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0090-3493 J9 CRIT CARE MED JI Crit. Care Med. PD DEC PY 2012 VL 40 IS 12 SU S MA 923 BP U251 EP U252 PG 2 WC Critical Care Medicine SC General & Internal Medicine GA 050HZ UT WOS:000312045701192 ER PT J AU Borgman, M Matos, R Spinella, P AF Borgman, Matthew Matos, Renee Spinella, Philip TI ISOLATED PEDIATRIC BURN INJURY IN IRAQ AND AFGHANISTAN SO CRITICAL CARE MEDICINE LA English DT Meeting Abstract CT 42nd Critical Care Congress of the Society-of-Critical-Care-Medicine CY JAN 19-23, 2013 CL San Juan, PR SP Soc Crit Care Medi C1 [Borgman, Matthew; Matos, Renee] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. [Spinella, Philip] Washington Univ, St Louis, MO 63130 USA. RI Borgman, Matthew/L-9477-2015 OI Borgman, Matthew/0000-0002-2008-7380 NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0090-3493 J9 CRIT CARE MED JI Crit. Care Med. PD DEC PY 2012 VL 40 IS 12 SU S MA 244 BP U72 EP U73 PG 2 WC Critical Care Medicine SC General & Internal Medicine GA 050HZ UT WOS:000312045700207 ER PT J AU Holloway, T Cap, A Schwacha, M AF Holloway, Travis Cap, Andrew Schwacha, Martin TI ASSOCIATION OF THE TH-17 IMMUNE RESPONSE WITH PULMONARY COMPLICATIONS IN A TRAUMA ICU POPULATION SO CRITICAL CARE MEDICINE LA English DT Meeting Abstract CT 42nd Critical Care Congress of the Society-of-Critical-Care-Medicine CY JAN 19-23, 2013 CL San Juan, PR SP Soc Crit Care Medi C1 [Cap, Andrew] USA, Inst Surg Res, Washington, DC USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0090-3493 J9 CRIT CARE MED JI Crit. Care Med. PD DEC PY 2012 VL 40 IS 12 SU S MA 204 BP U62 EP U62 PG 1 WC Critical Care Medicine SC General & Internal Medicine GA 050HZ UT WOS:000312045700169 ER PT J AU Hourigan, L Omaye, S Keen, C Jones, J Dubick, M AF Hourigan, Leslie Omaye, Stanley Keen, Carl Jones, John Dubick, Michael TI VITAMIN AND TRACE ELEMENT LOSS FROM WOUND EXUDATES IN PATIENTS UNDERGOING NEGATIVE PRESSURE WOUND THERAPY (NPWT) SO CRITICAL CARE MEDICINE LA English DT Meeting Abstract CT 42nd Critical Care Congress of the Society-of-Critical-Care-Medicine CY JAN 19-23, 2013 CL San Juan, PR SP Soc Crit Care Medi C1 [Hourigan, Leslie] San Antonio Mil Med Ctr, San Antonio, TX USA. [Omaye, Stanley] Univ Nevada, Reno, NV 89557 USA. [Keen, Carl] Univ Calif Davis, Davis, CA 95616 USA. [Jones, John; Dubick, Michael] USA, Inst Surg Res, Washington, DC USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0090-3493 J9 CRIT CARE MED JI Crit. Care Med. PD DEC PY 2012 VL 40 IS 12 SU S MA 1007 BP U273 EP U273 PG 1 WC Critical Care Medicine SC General & Internal Medicine GA 050HZ UT WOS:000312045701274 ER PT J AU Kheriabadi, B AF Kheriabadi, Bijan TI NEGATIVE PRESSURE WOUND THERAPY (NPWT): AN EFFECTIVE ADJUNCT FOR CONTROL OF ARTERIAL HEMORRHAGE IN A JUNCTIONAL WOUND SO CRITICAL CARE MEDICINE LA English DT Meeting Abstract CT 42nd Critical Care Congress of the Society-of-Critical-Care-Medicine CY JAN 19-23, 2013 CL San Juan, PR SP Soc Crit Care Medi C1 [Kheriabadi, Bijan] USA, Inst Surg Res, Washington, DC USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0090-3493 J9 CRIT CARE MED JI Crit. Care Med. PD DEC PY 2012 VL 40 IS 12 SU S MA 242 BP U72 EP U72 PG 1 WC Critical Care Medicine SC General & Internal Medicine GA 050HZ UT WOS:000312045700205 ER PT J AU Mann-Salinas, E Jones, J Cancio, L Chung, K AF Mann-Salinas, Elizabeth Jones, John Cancio, Leopoldo Chung, Kevin TI EFFECT OF THE NICE-SUGAR STUDY ON BURN PATIENT OUTCOMES: DO HIGHER GLYCEMIC TARGETS MAKE A DIFFERENCE? SO CRITICAL CARE MEDICINE LA English DT Meeting Abstract CT 42nd Critical Care Congress of the Society-of-Critical-Care-Medicine CY JAN 19-23, 2013 CL San Juan, PR SP Soc Crit Care Medi C1 [Mann-Salinas, Elizabeth; Jones, John; Cancio, Leopoldo; Chung, Kevin] USA, Inst Surg Res, Washington, DC USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0090-3493 J9 CRIT CARE MED JI Crit. Care Med. PD DEC PY 2012 VL 40 IS 12 SU S MA 238 BP U71 EP U71 PG 1 WC Critical Care Medicine SC General & Internal Medicine GA 050HZ UT WOS:000312045700201 ER PT J AU Martini, W Moreno, C Guerra, J DeGuzman, R Cap, A Sondeen, J Dubick, M AF Martini, Wenjun Moreno, Cassandra Guerra, Jessica DeGuzman, Rodolfo Cap, Andrew Sondeen, Jill Dubick, Michael TI DOSE RESPONSES OF IBUPROFEN ON PLATELET AGGREGATION AND COAGULATION IN HUMAN BLOOD IN VITRO SO CRITICAL CARE MEDICINE LA English DT Meeting Abstract CT 42nd Critical Care Congress of the Society-of-Critical-Care-Medicine CY JAN 19-23, 2013 CL San Juan, PR SP Soc Crit Care Medi C1 [Martini, Wenjun; Moreno, Cassandra; Guerra, Jessica; DeGuzman, Rodolfo; Cap, Andrew; Sondeen, Jill; Dubick, Michael] USA, Inst Surg Res, Natick, MA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0090-3493 J9 CRIT CARE MED JI Crit. Care Med. PD DEC PY 2012 VL 40 IS 12 SU S MA 180 BP U56 EP U56 PG 1 WC Critical Care Medicine SC General & Internal Medicine GA 050HZ UT WOS:000312045700145 ER PT J AU Salinas, J Serio-Melvin, M Fenrich, C Chung, K Kramer, G Cancio, L AF Salinas, Jose Serio-Melvin, Maria Fenrich, Craig Chung, Kevin Kramer, George Cancio, Leopoldo TI REVIEW OF PATIENTS RESUSCITATED USING A COMPUTERIZED DECISION SUPPORT SYSTEM IN A BURN INTENSIVE CARE UNIT SO CRITICAL CARE MEDICINE LA English DT Meeting Abstract CT 42nd Critical Care Congress of the Society-of-Critical-Care-Medicine CY JAN 19-23, 2013 CL San Juan, PR SP Soc Crit Care Medi C1 [Salinas, Jose; Serio-Melvin, Maria; Fenrich, Craig; Chung, Kevin; Cancio, Leopoldo] USA, Inst Surg Res, Washington, DC USA. NR 0 TC 0 Z9 0 U1 1 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0090-3493 J9 CRIT CARE MED JI Crit. Care Med. PD DEC PY 2012 VL 40 IS 12 SU S MA 225 BP U67 EP U67 PG 1 WC Critical Care Medicine SC General & Internal Medicine GA 050HZ UT WOS:000312045700188 ER PT J AU Shields, B Ojo, A Aden, J VanSickle, C White, C AF Shields, Beth Ojo, Anne Aden, James VanSickle, Christina White, Christopher TI INFLUENCE OF REMAINING OPEN WOUND SIZE AND TIME SINCE INJURY ON RESTING ENERGY EXPENDITURE IN BURN PATIENTS SO CRITICAL CARE MEDICINE LA English DT Meeting Abstract CT 42nd Critical Care Congress of the Society-of-Critical-Care-Medicine CY JAN 19-23, 2013 CL San Juan, PR SP Soc Crit Care Medi C1 [Shields, Beth] San Antonio Mil Med Ctr, San Antonio, TX USA. [Ojo, Anne; Aden, James; VanSickle, Christina; White, Christopher] USA, Inst Surg Res, Washington, DC USA. NR 0 TC 1 Z9 1 U1 1 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0090-3493 J9 CRIT CARE MED JI Crit. Care Med. PD DEC PY 2012 VL 40 IS 12 SU S MA 329 BP U95 EP U95 PG 1 WC Critical Care Medicine SC General & Internal Medicine GA 050HZ UT WOS:000312045700292 ER PT J AU Shields, B VanSickle, C Villanueva, P Aden, J Ojo, A White, C AF Shields, Beth VanSickle, Christina Villanueva, Peter Aden, James Ojo, Anne White, Christopher TI RESTING ENERGY EXPENDITURE AND VENTILATOR MODES IN THERMALLY INJURED PATIENTS SO CRITICAL CARE MEDICINE LA English DT Meeting Abstract CT 42nd Critical Care Congress of the Society-of-Critical-Care-Medicine CY JAN 19-23, 2013 CL San Juan, PR SP Soc Crit Care Medi C1 [Shields, Beth] San Antonio Mil Med Ctr, San Antonio, TX USA. [VanSickle, Christina; Villanueva, Peter; Aden, James; Ojo, Anne; White, Christopher] USA, Inst Surg Res, Washington, DC USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0090-3493 J9 CRIT CARE MED JI Crit. Care Med. PD DEC PY 2012 VL 40 IS 12 SU S MA 326 BP U94 EP U95 PG 2 WC Critical Care Medicine SC General & Internal Medicine GA 050HZ UT WOS:000312045700289 ER PT J AU Kamnaksh, A Kwon, SK Kovesdi, E Ahmed, F Barry, ES Grunberg, NE Long, J Agoston, D AF Kamnaksh, Alaa Kwon, Sook-Kyung Kovesdi, Erzsebet Ahmed, Farid Barry, Erin S. Grunberg, Neil E. Long, Joseph Agoston, Denes TI Neurobehavioral, cellular, and molecular consequences of single and multiple mild blast exposure SO ELECTROPHORESIS LA English DT Article DE Blast; Cumulative effect; Neurobehavior; Protein biomarkers; Traumatic brain injury ID TRAUMATIC BRAIN-INJURY; POSTTRAUMATIC-STRESS-DISORDER; HIPPOCAMPAL SLICE CULTURES; ENDOTHELIAL GROWTH-FACTOR; ISCHEMIA/REPERFUSION INJURY; ADULT HIPPOCAMPUS; COMBAT VETERANS; IRAQI FREEDOM; NEUROGENESIS; PTSD AB Mild traumatic brain injury, caused by the exposure to single or repeated blast overpressure, is a principal concern due to its pathological complexity and neurobehavioral similarities with posttraumatic stress disorder. In this study, we exposed rats to a single or multiple (five total; administered on consecutive days) mild blasts, assessed their behavior at 1 and 16 days postinjury) and performed histological and protein analyses of brains and plasma at an early (2 h) and a late (22 days) termination time point. One day postinjury, multiple-injured (MI) rats showed the least general locomotion and the most depression- and anxiety-related behaviors among the experimental groups; there were no such differences at 16 days. However, at the later time point, both injured groups displayed elevated levels of select protein biomarkers. Histology showed significantly increased numbers of TUNEL+ (terminal-deoxy-transferase-mediated dUTP nick-end labeling)-positive cells in the dorsal and ventral hippocampus (DHC and VHC) of both injured groups as early as 2 h after injury. At 22 days, the increase was limited to the VHC of MI animals. Our findings suggest that the exposure to mild blast overpressure triggers early hippocampal cell death as well as neuronal, glial, and vascular damage that likely contribute to significant, albeit transient increases in depression- and anxiety-related behaviors. However, the severity of the observed pathological changes in MI rats failed to support the hypothesized cumulative effect of repeated injury. We infer that at this blast frequency, a potential conditioning phenomenon counteracts with and reduces the extent of subsequent damage in MI rats. C1 [Agoston, Denes] Uniformed Serv Univ Hlth Sci, Dept Anat Physiol & Genet, Sch Med, Bethesda, MD 20814 USA. [Kamnaksh, Alaa; Kwon, Sook-Kyung; Ahmed, Farid; Barry, Erin S.; Grunberg, Neil E.; Agoston, Denes] Uniformed Serv Univ Hlth Sci, Ctr Neurosci & Regenerat Med, Bethesda, MD 20814 USA. [Kovesdi, Erzsebet] US Dept Vet Affairs, Vet Affairs Cent Off, Washington, DC USA. [Barry, Erin S.; Grunberg, Neil E.] Walter Reed Army Inst Res, Dept Med & Clin Psychol, Silver Spring, MD USA. [Long, Joseph] Walter Reed Army Inst Res, Blast Induced Neurotrauma Branch, Ctr Mil Psychiat & Neurosci, Silver Spring, MD USA. RP Agoston, D (reprint author), Uniformed Serv Univ Hlth Sci, Dept Anat Physiol & Genet, Sch Med, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA. EM vagoston@usuhs.edu FU Center for Neuroscience and Regenerative Medicine [G1703F] FX We thank the Neurotrauma Team at the Walter Reed Army Institute of Research for their technical help during the exposures. This work was supported by the Center for Neuroscience and Regenerative Medicine grant number G1703F. The views, opinions, and/or findings contained herein are those of the authors and should not be construed as an official position, policy, or decision of the Department of the Army or the Department of Defense. Animal handling and treatments were conducted in compliance with the Animal Welfare Act and other Federal statutes and regulations related to animals and experiments involving animals, and adhered to principles stated in the Guide to the Care and Use of Laboratory Animals, National Research Council. The facilities are fully accredited by the Association for Assessment and Accreditation of Laboratory Animal Care International. NR 68 TC 18 Z9 19 U1 1 U2 17 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0173-0835 J9 ELECTROPHORESIS JI Electrophoresis PD DEC PY 2012 VL 33 IS 24 SI SI BP 3680 EP 3692 DI 10.1002/elps.201200319 PG 13 WC Biochemical Research Methods; Chemistry, Analytical SC Biochemistry & Molecular Biology; Chemistry GA 057FT UT WOS:000312548900011 PM 23161523 ER PT J AU Boutte, AM Yao, CP Kobeissy, F Lu, XCM Zhang, ZQ Wang, KK Schmid, K Tortella, FC Dave, JR AF Boutte, Angela M. Yao, Changping Kobeissy, Firas Lu, Xi-Chun May Zhang, Zhiqun Wang, Kevin K. Schmid, Kara Tortella, Frank C. Dave, Jitendra R. TI Proteomic analysis and brain-specific systems biology in a rodent model of penetrating ballistic-like brain injury SO ELECTROPHORESIS LA English DT Article DE Biomarker; Penetrating ballistic-like brain injury; Proteomics; Systems biology; UCH-L1 ID C-TERMINAL HYDROLASE-L1; PROLIFERATION MARKER; BARRIER PERMEABILITY; METABOLIC CRISIS; RAT MODEL; BIOMARKER; SERUM; SUPPLEMENTATION; MICRODIALYSIS; INFLAMMATION AB Proteomics and systems biology have significantly contributed to biomarker discovery in the field of brain injury. This study utilized 2D-DIGE-PMF-MS as a preliminary screen to detect biomarkers in a rat model of penetrating ballistic-like brain injury (PBBI). Brain-specific systems biology analysis of brain tissue identified 386 proteins having a fold change of more than 2, of which 321 proteins were increased and 65 were decreased 24 h after PBBI compared to sham controls. The majority of upregulated proteins were cytoskeletal (10.5%), nucleic acid binding (9.3%), or kinases (8.9%). Most proteins were involved in protein metabolism (22.7%), signal transduction (20.4%), and development (9.6%). Pathway analysis indicated that these proteins were involved in neurite outgrowth and cell differentiation. Semiquantitative Western blotting of 6, 24, 48, and 72 h after PBBI indicated ubiquitin carboxyl-terminal hydrolase isozyme L1 (a proposed traumatic brain injury biomarker in human clinical trials), tyrosine hydroxylase, and syntaxin-6 were found to be consistently elevated in brain tissue and cerebral spinal fluid after PBBI compared to sham controls. Combining proteomics and brain-specific systems biology can define underlying mechanisms of traumatic brain injury and provide valuable information in biomarker discovery that, in turn, may lead to novel therapeutic targets. C1 [Dave, Jitendra R.] Walter Reed Army Inst Res, Brain Trauma Neuroprotect & Neurorestorat Branch, Div Psychiat & Neurosci, Silver Spring, MD 20910 USA. [Kobeissy, Firas; Zhang, Zhiqun; Wang, Kevin K.] Univ Florida, Dept Psychiat & Neurosci, Ctr Neuroprote & Biomarkers Res, Gainesville, FL USA. RP Dave, JR (reprint author), Walter Reed Army Inst Res, Brain Trauma Neuroprotect & Neurorestorat Branch, Div Psychiat & Neurosci, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM jit.dave@amedd.army.mil RI kobeissy, firas/E-7042-2017; Dave, Jitendra/A-8940-2011 OI kobeissy, firas/0000-0002-5008-6944; Wang, Kevin/0000-0002-9343-6473; FU Banyan Biomarkers, Inc. FX The authors have declared the following potential conflict of interest: Drs. Kevin K. W. Wang and Ronald L. Hayes, an executive officer at Banyan Biomarkers, Inc., own stock and receive royalties from Banyan Biomarkers, Inc., and as such may benefit financially as a result of the outcomes of this research or work reported in this publication. NR 53 TC 11 Z9 11 U1 0 U2 23 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0173-0835 J9 ELECTROPHORESIS JI Electrophoresis PD DEC PY 2012 VL 33 IS 24 SI SI BP 3693 EP 3704 DI 10.1002/elps.201200196 PG 12 WC Biochemical Research Methods; Chemistry, Analytical SC Biochemistry & Molecular Biology; Chemistry GA 057FT UT WOS:000312548900012 PM 23161467 ER PT J AU Ahmed, F Gyorgy, A Kamnaksh, A Ling, G Tong, L Parks, S Agoston, D AF Ahmed, Farid Gyorgy, Andrea Kamnaksh, Alaa Ling, Geoffrey Tong, Lawrence Parks, Steve Agoston, Denes TI Time-dependent changes of protein biomarker levels in the cerebrospinal fluid after blast traumatic brain injury SO ELECTROPHORESIS LA English DT Article DE Biomarkers; Blast traumatic brain injury; CSF; Large animal model; Proteins ID NEURON-SPECIFIC ENOLASE; ENDOTHELIAL GROWTH-FACTOR; VON-WILLEBRAND-FACTOR; NERVOUS-SYSTEM INJURY; CREATINE-KINASE BB; EXPLOSIVE BLAST; HEAD-INJURY; CSF BIOMARKERS; FACTOR VEGF; S100B AB Time-dependent changes of protein biomarkers in the cerebrospinal fluid (CSF) can be used to identify the pathological processes in traumatic brain injury (TBI) as well as to follow the progression of the disease. We obtained CSF from a large animal model (swine) of blast-induced traumatic brain injury prior to and at 6, 24, 72 h, and 2 wk after a single exposure to blast overpressure, and determined changes in the CSF levels of neurofilament-heavy chain, neuron-specific enolase, brain-specific creatine kinase, glial fibrillary acidic protein, calcium-binding protein beta (S100 beta), Claudin-5, vascular endothelial growth factor, and von Willebrand factor using reverse phase protein microarray. We detected biphasic temporal patterns in the CSF concentrations of all tested protein markers except S100 beta. The CSF levels of all markers were significantly increased 6 h after the injury compared to preinjury levels. Values were then decreased at 24 h, prior to a second increase in all markers but S100 beta at 72 h. At 2 wk postinjury, the CSF concentrations of all biomarkers were decreased once again; brain-specific creatine kinase, Claudin-5, von Willebrand factor, and S100 beta levels were no longer significantly higher than their preinjury values while neurofilament-heavy chain, neuron-specific enolase, vascular endothelial growth factor, and glial fibrillary acidic protein levels remained significantly elevated compared to baseline. Our findings implicate neuronal and glial cell damage, compromised vascular permeability, and inflammation in blast-induced traumatic brain injury, as well as demonstrate the value of determining the temporal pattern of biomarker changes that may be of diagnostic value. C1 [Ahmed, Farid; Gyorgy, Andrea; Kamnaksh, Alaa; Agoston, Denes] Uniformed Serv Univ Hlth Sci, Dept Anat Physiol & Genet, Bethesda, MD 20814 USA. [Ling, Geoffrey] Uniformed Serv Univ Hlth Sci, Dept Neurol, Bethesda, MD 20814 USA. [Tong, Lawrence] Walter Reed Army Inst Res, Blast Induced Neurotrauma Branch, Ctr Mil Psychiat & Neurosci, Silver Spring, MD USA. [Parks, Steve] ORA Inc, Fredericksburg, VA USA. RP Agoston, D (reprint author), Uniformed Serv Univ Hlth Sci, Dept Anat Physiol & Genet, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA. EM vagoston@usuhs.edu FU Defense Advanced Research Projects Agency's (DARPA) Preventing Violent Explosive Neurologic Trauma (PREVENT) FX The work was funded by the Defense Advanced Research Projects Agency's (DARPA) Preventing Violent Explosive Neurologic Trauma (PREVENT). We thank Dr. Mattias Skold for his input regarding the clinical implications of our findings. The views, opinions, and/or findings contained in this article are those of the authors and should not be interpreted as representing the official views or policies, either expressed or implied, of the Defense Advanced Research Projects Agency (DARPA) or the Department of Defense (DoD). Approved for public release; distribution unlimited. NR 90 TC 28 Z9 29 U1 0 U2 15 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0173-0835 J9 ELECTROPHORESIS JI Electrophoresis PD DEC PY 2012 VL 33 IS 24 SI SI BP 3705 EP 3711 DI 10.1002/elps.201200299 PG 7 WC Biochemical Research Methods; Chemistry, Analytical SC Biochemistry & Molecular Biology; Chemistry GA 057FT UT WOS:000312548900013 PM 23161535 ER PT J AU Zhang, SS AF Zhang, Sheng S. TI Improved Cyclability of Liquid Electrolyte Lithium/Sulfur Batteries by Optimizing Electrolyte/Sulfur Ratio SO ENERGIES LA English DT Article DE lithium/sulfur battery; electrolyte; cyclability; polysulfide; redox shuttle ID SULFUR BATTERIES; DISCHARGE PERFORMANCE; COMPOSITES; DENSITY; CELL AB A liquid electrolyte lithium/sulfur (Li/S) cell is a liquid electrochemical system. In discharge, sulfur is first reduced to highly soluble Li2S8, which dissolves into the organic electrolyte and serves as the liquid cathode. In solution, lithium polysulfide (PS) undergoes a series of complicated disproportionations, whose chemical equilibriums vary with the PS concentration and affect the cell's performance. Since the PS concentration relates to a certain electrolyte/sulfur (E/S) ratio, there is an optimized E/S ratio for the cyclability of each Li/S cell system. In this work, we study the optimized E/S ratio by measuring the cycling performance of Li/S cells, and propose an empirical method for determination of the optimized E/S ratio. By employing an electrolyte of 0.25 m LiSO3CF3-0.25 m LiNO3 dissolved in a 1:1 (wt:wt) mixture of dimethyl ether (DME) and 1,3-dioxolane (DOL) in an optimized E/S ratio, we show that the Li/S cell with a cathode containing 72% sulfur and 2 mg cm(-2) sulfur loading is able to retain a specific capacity of 780 mAh g(-1) after 100 cycles at 0.5 mA cm(-2) between 1.7 V and 2.8 V. C1 USA, Res Lab, Electrochem Branch, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA. RP Zhang, SS (reprint author), USA, Res Lab, Electrochem Branch, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA. EM shengshui.zhang.civ@mail.mil RI Zhang, Sheng/A-4456-2012 OI Zhang, Sheng/0000-0003-4435-4110 NR 19 TC 67 Z9 67 U1 14 U2 190 PU MDPI AG PI BASEL PA POSTFACH, CH-4005 BASEL, SWITZERLAND SN 1996-1073 J9 ENERGIES JI Energies PD DEC PY 2012 VL 5 IS 12 BP 5190 EP 5197 DI 10.3390/en5125190 PG 8 WC Energy & Fuels SC Energy & Fuels GA 058AR UT WOS:000312607000016 ER PT J AU Min, JK Berman, DS Dunning, A Achenbach, S Al-Mallah, M Budoff, MJ Cademartiri, F Callister, TQ Chang, HJ Cheng, V Chinnaiyan, K Chow, BJW Cury, R Delago, A Feuchtner, G Hadamitzky, M Hausleiter, J Kaufmann, P Karlsberg, RP Kim, YJ Leipsic, J Lin, FY Maffei, E Plank, F Raff, G Villines, T Labounty, TM Shaw, LJ AF Min, James K. Berman, Daniel S. Dunning, Allison Achenbach, Stephan Al-Mallah, Mouaz Budoff, Matthew J. Cademartiri, Filippo Callister, Tracy Q. Chang, Hyuk-Jae Cheng, Victor Chinnaiyan, Kavitha Chow, Benjamin J. W. Cury, Ricardo Delago, Augustin Feuchtner, Gudrun Hadamitzky, Martin Hausleiter, Joerg Kaufmann, Philipp Karlsberg, Ronald P. Kim, Yong-Jin Leipsic, Jonathon Lin, Fay Y. Maffei, Erica Plank, Fabian Raff, Gilbert Villines, Todd Labounty, Troy M. Shaw, Leslee J. TI All-cause mortality benefit of coronary revascularization vs. medical therapy in patients without known coronary artery disease undergoing coronary computed tomographic angiography: results from CONFIRM (COronary CT Angiography EvaluatioN For Clinical Outcomes: An InteRnational Multicenter Registry) SO EUROPEAN HEART JOURNAL LA English DT Article DE Computed tomography; Coronary revascularization; Medical therapy; Coronary artery disease ID INCREMENTAL PROGNOSTIC VALUE; DIAGNOSTIC PERFORMANCE; INTERVENTION; PREDICTION; SCINTIGRAPHY; INDIVIDUALS; 2-CENTER; SURGERY; STENTS; DEATH AB Aims To date, the therapeutic benefit of revascularization vs. medical therapy for stable individuals undergoing invasive coronary angiography (ICA) based upon coronary computed tomographic angiography (CCTA) findings has not been examined. Methods and results We examined 15 223 patients without known coronary artery disease (CAD) undergoing CCTA from eight sites and six countries who were followed for median 2.1 years (interquartile range 1.4-3.3 years) for an endpoint of all-cause mortality. Obstructive CAD by CCTA was defined as a >= 50% luminal diameter stenosis in a major coronary artery. Patients were categorized as having high-risk CAD vs. non-high-risk CAD, with the former including patients with at least obstructive two-vessel CAD with proximal left anterior descending artery involvement, three-vessel CAD, and left main CAD. Death occurred in 185 (1.2%) patients. Patients were categorized into two treatment groups: revascularization (n = 1103; 2.2% mortality) and medical therapy (n = 14 120, 1.1% mortality). To account for non-randomized referral to revascularization, we created a propensity score developed by logistic regression to identify variables that influenced the decision to refer to revascularization. Within this model (C index 0.92, chi(2) = 1248, P < 0.0001), obstructive CAD was the most influential factor for referral, followed by an interaction of obstructive CAD with pre-test likelihood of CAD (P = 0.0344). Within CCTA CAD groups, rates of revascularization increased from 3.8% for non-high-risk CAD to 51.2% high-risk CAD. In multivariable models, when compared with medical therapy, revascularization was associated with a survival advantage for patients with high-risk CAD [hazards ratio (HR) 0.38, 95% confidence interval 0.18-0.83], with no difference in survival for patients with non-high-risk CAD (HR 3.24, 95% CI 0.76-13.89) (P-value for interaction = 0.03). Conclusion In an intermediate-term follow-up, coronary revascularization is associated with a survival benefit in patients with high-risk CAD by CCTA, with no apparent benefit of revascularization in patients with lesser forms of CAD. C1 [Min, James K.; Berman, Daniel S.; Cheng, Victor; Labounty, Troy M.] Cedars Sinai Med Ctr, Cedars Sinai Heart Inst, Dept Med Imaging & Biomed Sci, Los Angeles, CA 90048 USA. [Min, James K.; Berman, Daniel S.; Cheng, Victor; Labounty, Troy M.] Cedars Sinai Med Ctr, Dept Imaging, Los Angeles, CA 90048 USA. [Dunning, Allison] Weill Cornell Med Coll, Dept Publ Hlth, New York, NY USA. [Dunning, Allison; Lin, Fay Y.] New York Presbyterian Hosp, New York, NY USA. [Achenbach, Stephan] Univ Erlangen Nurnberg, Dept Med, Erlangen, Germany. [Al-Mallah, Mouaz] Wayne State Univ, Dept Med, Henry Ford Hosp, Detroit, MI 48202 USA. [Budoff, Matthew J.] Harbor UCLA Med Ctr, Dept Med, Los Angeles, CA USA. [Cademartiri, Filippo; Maffei, Erica] Giovanni XXIII Hosp, Dept Radiol, Treviso, Italy. [Cademartiri, Filippo; Maffei, Erica] Erasmus MC, Dept Radiol, Rotterdam, Netherlands. [Callister, Tracy Q.] Tennessee Heart & Vasc Inst, Hendersonville, TN USA. [Chang, Hyuk-Jae] Severance Cardiovasc Hosp, Div Cardiol, Seoul, South Korea. [Chinnaiyan, Kavitha; Raff, Gilbert] William Beaumont Hosp, Royal Oak, MI USA. [Chow, Benjamin J. W.] Univ Ottawa, Dept Med & Radiol, Ottawa, ON K1N 6N5, Canada. [Cury, Ricardo] Baptist Cardiac & Vasc Inst, Miami, FL USA. [Delago, Augustin] Capitol Cardiol Associates, Albany, NY USA. [Feuchtner, Gudrun; Plank, Fabian] Med Univ Innsbruck, Dept Radiol, Innsbruck, Austria. [Hadamitzky, Martin; Hausleiter, Joerg] Deutsch Herzzentrum Munich, Div Cardiol, Munich, Germany. [Kaufmann, Philipp] Univ Zurich Hosp, CH-8091 Zurich, Switzerland. [Karlsberg, Ronald P.] Cardiovasc Med Grp, Los Angeles, CA USA. [Kim, Yong-Jin] Seoul Natl Univ Hosp, Seoul 110744, South Korea. [Leipsic, Jonathon] Univ British Columbia, Dept Radiol, Vancouver, BC, Canada. [Lin, Fay Y.] Weill Cornell Med Coll, Dept Med, New York, NY USA. [Villines, Todd] Walter Reed Army Med Ctr, Dept Med, Washington, DC 20307 USA. [Shaw, Leslee J.] Emory Univ, Sch Med, Dept Med, Atlanta, GA USA. RP Min, JK (reprint author), Cedars Sinai Med Ctr, Cedars Sinai Heart Inst, Dept Med Imaging & Biomed Sci, 8700 Beverly Blvd,S Taper Bldg 1258, Los Angeles, CA 90048 USA. EM james.min@cshs.org RI Cademartiri, Filippo/H-7336-2015; Maffei, Erica/J-2370-2016 OI Cademartiri, Filippo/0000-0002-0579-3279; Maffei, Erica/0000-0002-0388-4433 FU GE Healthcare FX J.M. received research support, serves on the speaker's bureau, and is a consultant to GE Healthcare. NR 34 TC 27 Z9 27 U1 0 U2 9 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 0195-668X J9 EUR HEART J JI Eur. Heart J. PD DEC PY 2012 VL 33 IS 24 BP 3088 EP 3097 DI 10.1093/eurheartj/ehs315 PG 10 WC Cardiac & Cardiovascular Systems SC Cardiovascular System & Cardiology GA 058NC UT WOS:000312639600018 PM 23048194 ER PT J AU Clancy, HA Costa, M AF Clancy, Hailey A. Costa, Max TI Nickel: a pervasive carcinogen SO FUTURE ONCOLOGY LA English DT Editorial Material ID AMBIENT AIR; PARTICULATE; LUNG; MECHANISMS; TOXICITY C1 [Costa, Max] NYU, Sch Med, Nelson Inst Environm Med, Dept Environm Hlth Sci, Tuxedo Pk, NY 10987 USA. [Clancy, Hailey A.] US Mil Acad, Dept Chem & Life Sci, West Point, NY 10996 USA. RP Costa, M (reprint author), NYU, Sch Med, Nelson Inst Environm Med, Dept Environm Hlth Sci, 57 Old Forge Rd, Tuxedo Pk, NY 10987 USA. EM max.costa@nyumc.org NR 21 TC 4 Z9 4 U1 0 U2 12 PU FUTURE MEDICINE LTD PI LONDON PA UNITEC HOUSE, 3RD FLOOR, 2 ALBERT PLACE, FINCHLEY CENTRAL, LONDON, N3 1QB, ENGLAND SN 1479-6694 J9 FUTURE ONCOL JI Future Oncol. PD DEC PY 2012 VL 8 IS 12 BP 1507 EP 1509 DI 10.2217/FON.12.154 PG 3 WC Oncology SC Oncology GA 050HB UT WOS:000312042700002 PM 23231511 ER PT J AU Chen, S Song, XY Chen, XQ Chen, Y Barbero, EJ Thomas, EL Barnes, PN AF Chen, Song Song, Xueyan Chen, Xueqin Chen, Yun Barbero, Ever J. Thomas, Evan L. Barnes, Paul N. TI Effect of precursor calcination temperature on the microstructure and thermoelectric properties of Ca3Co4O9 ceramics SO JOURNAL OF SOL-GEL SCIENCE AND TECHNOLOGY LA English DT Article DE Sol-gel methods; Cobalt oxide; Calcination; Thermoelectric properties; Nanostructure ID GRAIN-BOUNDARY; OXIDE; COBALTITES; CONVERSION; TEMPLATES AB Ca3Co4O9 (CCO) powder precursors were prepared by the chemical sol-gel route and calcined at various temperatures between 923 K (CCO-923 K) and 1,073 K (CCO-1,073 K). The calcination temperature was found to be a critical factor affecting the microstructure and thermoelectric properties of CCO ceramic bulk samples. The grain size increases with calcination temperature. The nano-crystals with size about 100 nm in the powders calcined at 923 K promote large crystal growth and texture development during sintering. Bulk pellets made from CCO-923 K powder have large crystal grains, uniform grain size distribution, and a high degree of crystal alignment. By contrast, pellets made from CCO powders at higher calcination temperatures have a bimodal distribution of large and small grains and a large amount of randomly oriented grains. Transmission electron microscopy analysis shows that each crystal grain (identified in SEM images) consists of bundles of CCO nano-lamellas. The nano-lamellas within one bundle share the same c-axis orientation and have fiber texture. The electrical resistivity of CCO-923 K is weakly dependent on operating temperature. Compared to the CCO-1,073 K sample, the CCO-923 K sample has the highest power factor, a lower thermal conductivity, and higher electrical conductivity. C1 [Chen, Song; Song, Xueyan; Chen, Xueqin; Chen, Yun; Barbero, Ever J.] W Virginia Univ, Dept Mech & Aerosp Engn, Morgantown, WV 26506 USA. [Thomas, Evan L.] Univ Dayton, AF Res Lab WPAFB, Energy Technol & Mat Div, Res Inst, Dayton, OH 45469 USA. [Barnes, Paul N.] Army Res Lab, Adelphi, MD 20783 USA. RP Song, XY (reprint author), W Virginia Univ, Dept Mech & Aerosp Engn, Evansdale Dr, Morgantown, WV 26506 USA. EM xueyan.song@mail.wvu.edu RI Chen, Song/H-3174-2011 FU West Virginia-Energy Materials Program [EPS08-01] FX Air-Force Summer Faculty Fellowship, West Virginia-Energy Materials Program (Grant EPS08-01), and West Virginia University Advanced Energy Initiative. NR 20 TC 8 Z9 9 U1 4 U2 81 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0928-0707 J9 J SOL-GEL SCI TECHN JI J. Sol-Gel Sci. Technol. PD DEC PY 2012 VL 64 IS 3 BP 627 EP 636 DI 10.1007/s10971-012-2894-4 PG 10 WC Materials Science, Ceramics SC Materials Science GA 057SS UT WOS:000312584900012 ER PT J AU Green, J Kongoli, C Prakash, A Sturm, M Duguay, C Li, SS AF Green, Jeff Kongoli, Cezar Prakash, Anupma Sturm, Mathew Duguay, Claude Li, Shusun TI Quantifying the relationships between lake fraction, snow water equivalent and snow depth, and microwave brightness temperatures in an arctic tundra landscape SO REMOTE SENSING OF ENVIRONMENT LA English DT Article DE Snow water equivalent; Snow depth; Passive microwave; AMSR-E; SSM/I; Arctic tundra; Lake fraction ID WESTERN CANADA; ICE THICKNESS; ALASKA; WINTER; COVER; RETRIEVALS; MODEL; REMOTE; USA AB This study investigates the effects of sub-grid lake variability on brightness temperature measurements and snow mass retrieval from passive microwave satellite data in the North Slope of Alaska. In situ snow measurements of water equivalent, depth and density collected from field surveys during 1996-2004 snow seasons were collocated with gridded SSM/I brightness temperatures. Sub-grid lake fraction was computed from a high-resolution land cover map derived from LANDSAT imagery. Another dataset was created consisting of multi-year time series of SSM/I and AMSR-E brightness temperatures and computed lake fraction. Consistent with other studies, it was found that lake fraction was negatively correlated with in situ snow depth and snow water equivalent and positively correlated with snow density, which indicates that lakes have a direct effect on snow cover distribution: They accumulate less but denser snow than surrounding land areas. Additionally, lake fraction was positively correlated with the brightness temperature measurements at 18 GHz and above, but negatively correlated with the AMSR-E brightness temperatures at low frequency channels (6 and 10 GHz), with the highest correlation values for the SSM/I (r = 0.57) and AMSR-E (r = 0.65) at 37 GHz dominating the response. Brightness temperature-based lake fraction algorithms were derived using stepwise regression. Performance assessment showed that the AMSR-E algorithm was superior to the SSM/I algorithm due to the use of the low frequency measurements not available from the SSM/I instrument. Combined lake fraction- and SSM/I brightness temperature-based snow depth and snow water equivalent algorithms were also derived using stepwise regression, with improved performance compared to conventional brightness temperature-based algorithms. (c) 2012 Elsevier Inc. All rights reserved. C1 [Kongoli, Cezar] NESDIS, NOAA, STAR, Camp Springs, MD 20746 USA. [Green, Jeff; Prakash, Anupma; Li, Shusun] Univ Alaska Fairbanks, Inst Geophys, Fairbanks, AK USA. [Kongoli, Cezar] Univ Maryland, Earth Syst Sci Interdisciplinary Ctr, College Pk, MD 20742 USA. [Sturm, Mathew] USA, Corps Engineers, Cold Reg Res & Engn Lab, Washington, DC USA. [Duguay, Claude] Univ Waterloo, Dept Geog & Environm Management, Waterloo, ON N2L 3G1, Canada. RP Kongoli, C (reprint author), NESDIS, NOAA, STAR, 5200 Auth Rd,711 WWB, Camp Springs, MD 20746 USA. EM Cezar.Kongoli@noaa.gov FU Geophysical Institute, University of Alaska Fairbanks FX This research was supported by a grant from the Geophysical Institute, University of Alaska Fairbanks, to C. Duguay and J. Green. The SSM/I and AMSR-E brightness temperature data were obtained from the EOSDIS National Snow and Ice Data Center Distributed Active Archive Center (NSIDC DACC), University of Colorado at Boulder. The snow and SWE data were provided by the University of Alaska Fairbanks Water and Environmental Research Center and the US Army Corps of Engineers Cold Regions Research and Engineering Laboratory. Land cover data was provided by the University of Alaska Fairbanks Geobotany Center. NR 41 TC 3 Z9 3 U1 2 U2 32 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0034-4257 EI 1879-0704 J9 REMOTE SENS ENVIRON JI Remote Sens. Environ. PD DEC PY 2012 VL 127 BP 329 EP 340 DI 10.1016/j.rse.2012.09.008 PG 12 WC Environmental Sciences; Remote Sensing; Imaging Science & Photographic Technology SC Environmental Sciences & Ecology; Remote Sensing; Imaging Science & Photographic Technology GA 047TY UT WOS:000311865600026 ER PT J AU Mishkind, MC Martin, S Husky, G Miyahira, SD Gahm, GA AF Mishkind, Matthew C. Martin, Suzanne Husky, George Miyahira, Sarah D. Gahm, Gregory A. TI The Use of Deployable Telehealth Centers by Military Beneficiaries to Access Behavioral Healthcare: An Exploratory Evaluation in American Samoa SO TELEMEDICINE AND E-HEALTH LA English DT Article DE telehealth; behavioral; healthcare; military; mobile ID POSTTRAUMATIC-STRESS-DISORDER; IRAQ; MOBILE; AFGHANISTAN; THERAPY; TECHNOLOGY; DEPLOYMENT; COMPONENT; VETERANS; COMBAT AB Some U.S. Military Health System (MHS) beneficiaries face unique challenges accessing available behavioral healthcare because of the nature of their occupations, deployments to and permanent duty stations in isolated geographies, and discontinuity of services. The use of deployable telehealth centers such as modified shipping containers offers promise as an innovative solution to increase access to behavioral healthcare in remote and otherwise austere environments. The first telehealth modified 20-foot shipping container, known as a relocatable telehealth center (RTeC), was deployed to increase access to care for MHS beneficiaries on American Samoa. The goal of this study was to conduct an exploratory evaluation of patient satisfaction with and usability perceptions of this solution as a place to receive behavioral healthcare services. Twenty-eight beneficiaries participated in this evaluation. Results suggest that the RTeC is safe and private and ultimately an appropriate telebehavioral-originating site. These data provide insight into usability considerations and inform future research and deployable telehealth center development. Additionally, a brief discussion about potential cost offset is provided as cost efficiencies impact RTeC viability. C1 [Mishkind, Matthew C.] Old Madigan Army Med Ctr, Def Ctr Excellence Psychol Hlth & Traumat Brain I, Natl Ctr Telehlth & Technol, Tacoma, WA 98431 USA. [Martin, Suzanne; Husky, George; Miyahira, Sarah D.] USA, Pacific Reg Med Command, Honolulu, HI USA. RP Mishkind, MC (reprint author), Old Madigan Army Med Ctr, Def Ctr Excellence Psychol Hlth & Traumat Brain I, Natl Ctr Telehlth & Technol, Bldg 9933, Tacoma, WA 98431 USA. EM matt.mishkind@us.army.mil NR 26 TC 3 Z9 3 U1 0 U2 2 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1530-5627 J9 TELEMED E-HEALTH JI Telemed. e-Health PD DEC PY 2012 VL 18 IS 10 BP 729 EP 735 DI 10.1089/tmj.2012.0023 PG 7 WC Health Care Sciences & Services SC Health Care Sciences & Services GA 055TN UT WOS:000312440600004 PM 23078182 ER PT J AU Nielsen, N Wirtz, E Freeman, J Klem, C AF Nielsen, Nathan Wirtz, Eric Freeman, Judy Klem, Christopher TI Pathology Quiz Case 1 Sclerosing Polycystic Adenosis (SPCA) SO ARCHIVES OF OTOLARYNGOLOGY-HEAD & NECK SURGERY LA English DT Editorial Material ID SALIVARY-GLANDS; PAROTID-GLAND; IN-SITU C1 [Nielsen, Nathan; Wirtz, Eric; Freeman, Judy; Klem, Christopher] Tripler Army Med Ctr, Honolulu, HI 96859 USA. RP Nielsen, N (reprint author), Tripler Army Med Ctr, Honolulu, HI 96859 USA. NR 10 TC 0 Z9 0 U1 0 U2 3 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60654-0946 USA SN 0886-4470 J9 ARCH OTOLARYNGOL JI Arch. Otolaryngol. Head Neck Surg. PD DEC PY 2012 VL 138 IS 12 BP 1191 EP 1193 PG 3 WC Otorhinolaryngology; Surgery SC Otorhinolaryngology; Surgery GA 055FS UT WOS:000312401300016 PM 23247244 ER PT J AU Sutcliffe, S Pakpahan, R Sokoll, LJ Elliott, DJ Nevin, RL Cersovsky, SB Walsh, PC Platz, EA AF Sutcliffe, Siobhan Pakpahan, Ratna Sokoll, Lori J. Elliott, Debra J. Nevin, Remington L. Cersovsky, Steven B. Walsh, Patrick C. Platz, Elizabeth A. TI Prostate-specific antigen concentration in young men: new estimates and review of the literature SO BJU INTERNATIONAL LA English DT Article DE prostate-specific antigen; Caucasian race; African Americans; review ID REFERENCE RANGES; HEALTHY-MEN; SERUM-LEVELS; EXOGENOUS TESTOSTERONE; BLACK-MEN; AGE; CANCER; POPULATION; PSA; EJACULATION AB OBJECTIVE To provide race-specific prostate-specific antigen (PSA) reference distributions for young men less than 40 years of age who might have undergone non-recommended PSA testing because of their family history of prostate cancer or inadvertently as part of a standard panel of tests. MATERIALS AND METHODS We used data from a large existing study of young, male Caucasian- and African-American members of the US military with stored serum in the Department of Defense serum repository. As part of this previous study, we selected a random sample of 373 Caucasian- and 366 African-American men aged 2836 years with an archived serum specimen collected for standard military purposes from 2004 to 2006. We measured serum total PSA concentration in this specimen using the Beckman Coulter Access Hybritech PSA assay. RESULTS The PSA level ranged from <0.01 to 3.34 ng/mL among Caucasian-American men, with a median of 0.56 ng/mL and a 95th percentile of 1.42 ng/mL. The PSA level ranged from 0.12 to 6.45 ng/mL among African-American men, with a median of 0.64 ng/mL and 95th percentile of 1.89 ng/mL. The PSA level was significantly higher in African- than in Caucasian-American men (P= 0.001). CONCLUSION The PSA estimates, together with those summarized from the literature, provide age- and race-specific PSA reference distributions for young men who might have undergone non-recommended PSA testing. Comparisons by race could also begin to inform the timing of divergence of prostate cancer risk by race. C1 [Sutcliffe, Siobhan; Pakpahan, Ratna] Washington Univ, Div Publ Hlth Sci, Sch Med, Dept Surg, St Louis, MO 63110 USA. [Sutcliffe, Siobhan] Washington Univ, Alvin J Siteman Canc Ctr, Sch Med, Dept Surg, St Louis, MO 63110 USA. [Sokoll, Lori J.; Elliott, Debra J.] Johns Hopkins Med Inst, Dept Pathol, Baltimore, MD 21205 USA. [Sokoll, Lori J.; Walsh, Patrick C.; Platz, Elizabeth A.] Johns Hopkins Med Inst, James Buchanan Brady Urol Inst, Baltimore, MD 21205 USA. [Sokoll, Lori J.; Walsh, Patrick C.; Platz, Elizabeth A.] Johns Hopkins Med Inst, Sidney Kimmel Comprehens Canc Ctr, Baltimore, MD 21205 USA. [Cersovsky, Steven B.] USA, Inst Publ Hlth, Publ Hlth Command Provis, Aberdeen Proving Ground, MD USA. [Platz, Elizabeth A.] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA. [Nevin, Remington L.] Bayne Jones Army Community Hosp, Dept Prevent Med, Folk Port, LA USA. RP Sutcliffe, S (reprint author), Washington Univ, Div Publ Hlth Sci, Sch Med, Dept Surg, 660 S Euclid Ave,Box 8100,Rm 5026, St Louis, MO 63110 USA. EM sutcliffes@wudosis.wustl.edu OI Sutcliffe, Siobhan/0000-0002-4613-8107; Nevin, Remington/0000-0002-0534-1889 FU Patrick C. Walsh Prostate Cancer Research Fund; Barnes-Jewish Hospital Foundation FX None declared. Source of funding: the Patrick C. Walsh Prostate Cancer Research Fund and the Barnes-Jewish Hospital Foundation. NR 58 TC 4 Z9 4 U1 0 U2 9 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1464-4096 J9 BJU INT JI BJU Int. PD DEC PY 2012 VL 110 IS 11 BP 1627 EP 1635 DI 10.1111/j.1464-410X.2012.11111.x PG 9 WC Urology & Nephrology SC Urology & Nephrology GA 053BY UT WOS:000312245900016 PM 22502603 ER PT J AU Matheny, RW Lynch, CM Leandry, LA AF Matheny, Ronald W., Jr. Lynch, Christine M. Leandry, Luis A. TI Enhanced Akt phosphorylation and myogenic differentiation in PI3K p110 beta-deficient myoblasts is mediated by PI3K p110 alpha and mTORC2 SO GROWTH FACTORS LA English DT Article DE PI3K; Akt; mTOR; myoblast; myogenesis ID PROTEIN-KINASE-B; SKELETAL-MUSCLE HYPERTROPHY; PHOSPHOINOSITIDE 3-KINASE BETA; PLECKSTRIN-HOMOLOGY-DOMAIN; LYSOPHOSPHATIDIC ACID; PHOSPHATIDYLINOSITOL 3-KINASE; SATELLITE CELL; COUPLED RECEPTORS; C2C12 MYOBLASTS; MAP KINASE AB Phosphoinositide 3-kinase (PI3K) is a principal regulator of Akt activation and myogenesis; however, the function of PI3K p110 beta in these processes is not well defined. To address this, we investigated the role of p110 beta in Akt activation and skeletal muscle cell differentiation. We found that Akt phosphorylation was enhanced in p110 beta-deficient myoblasts in response to Insulin-like Growth Factor-I (IGF-I), epidermal growth factor, or p110 alpha overexpression, as compared to p110 beta-sufficient cells. This effect was associated with increased mammalian target of rapamycin complex 2 activation, even in myoblasts deficient in mSin1 and rictor. Conversely, in response to the G-protein-coupled receptor agonist lysophosphatidic acid, Akt phosphorylation was attenuated in p110 beta-deficient myoblasts. Loss of p110 beta also enhanced the expression of myogenic markers at the myoblast stage and during the first 48 h of differentiation. These data demonstrate that reductions in p110 beta are associated with agonist-specific Akt hyperactivation and accelerated myogenesis, thus revealing a negative role for p110 beta in Akt activation and during myoblast differentiation. C1 [Matheny, Ronald W., Jr.; Lynch, Christine M.; Leandry, Luis A.] USA, Mil Performance Div, Environm Med Res Inst, Natick, MA 01760 USA. RP Matheny, RW (reprint author), USA, Mil Performance Div, Environm Med Res Inst, 15 Kansas St,Bldg 42, Natick, MA 01760 USA. EM ronald.matheny@us.army.mil FU US Department of Energy; USAMRMC FX This work was supported by an appointment to the Postgraduate Research Participation Program at the US Army Research Institute of Environmental Medicine administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the US Department of Energy and USAMRMC (CML). The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper. The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the Army or the Department of Defense. Citations of commercial organizations and trade names in this report do not constitute an official Department of the Army endorsement or approval of the products or services of these organizations. NR 86 TC 8 Z9 8 U1 0 U2 5 PU INFORMA HEALTHCARE PI LONDON PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND SN 0897-7194 J9 GROWTH FACTORS JI Growth Factors PD DEC PY 2012 VL 30 IS 6 BP 367 EP 384 DI 10.3109/08977194.2012.734507 PG 18 WC Cell Biology; Endocrinology & Metabolism SC Cell Biology; Endocrinology & Metabolism GA 052UB UT WOS:000312222900002 PM 23137199 ER PT J AU Crombie, AP Liu, PY Ormsbee, MJ Ilich, JZ AF Crombie, Aaron P. Liu, Pei-Yang Ormsbee, Michael J. Ilich, Jasminka Z. TI Weight and Body-Composition Change During the College Freshman Year in Male General-Population Students and Army Reserve Officer Training Corps (ROTC) Cadets SO INTERNATIONAL JOURNAL OF SPORT NUTRITION AND EXERCISE METABOLISM LA English DT Article DE body fat; muscle mass; physical activity; fitness level ID PHYSICAL-ACTIVITY; HEALTH BEHAVIORS; GAIN; MASS; QUESTIONNAIRES; FITNESS; OBESITY; WOMEN AB Purpose: To examine relationships between changes in body weight, body composition, and fitness level in male students of the general population and those in the Army Reserve Officer Training Corps (ROTC) program during the freshman year of college. Methods: Thirty-seven (18.4 +/- 0.7 yr) healthy, nonsmoking, first-semester-resident male students were divided into 3 groups: low active (LA), high active (HA), and ROTC. Baseline (beginning of freshman year) and 6-month follow-up measurements included anthropometry, body composition (by DXA), 3-day food records, and physical activity (PA) assessment. Results: Weight and body-mass index did not change significantly within or among groups. HA participants compared with LA and ROTC had a significant decrease in body fat (-1.6% +/- 2.5% vs. 1.9% +/- 1.2% and 0.8% +/- 2.2%, respectively). They also had a significant increase in lean mass compared with LA and ROTC (1.8 +/- 1.1 kg vs. -0.2 +/- 2.0 kg and 0.2 +/- 1.7 kg, respectively). All p values were <.05. ROTC and LA participants were similar in all measures of body composition and PA and had significantly lower PA levels than the HA group. No significant relationships were observed between dietary variables and body-composition changes. Conclusions: These results suggest that higher PA was the most powerful determinant in achieving favorable body-composition outcomes. In addition, current physical training conducted by ROTC at Florida State University (which seems to be a practice nationwide) might not be sufficient to offset gains in body fat. C1 [Crombie, Aaron P.] USA, Environm Med Res Inst, Mil Nutr Div, Natick, MA 01760 USA. [Liu, Pei-Yang] Univ Akron, Sch Family & Consumer Sci, Akron, OH 44325 USA. [Ormsbee, Michael J.; Ilich, Jasminka Z.] Florida State Univ, Dept Nutr Food & Exercise Sci, Tallahassee, FL 32306 USA. RP Crombie, AP (reprint author), USA, Environm Med Res Inst, Mil Nutr Div, Natick, MA 01760 USA. FU U.S. Army FX The authors would like to thank the U.S. Army for support of the author (ARC.). They would also like to thank the participants for their time and effort throughout the study. No funding was provided for this study, and there are no conflicts of interest from any author. NR 33 TC 4 Z9 4 U1 2 U2 13 PU HUMAN KINETICS PUBL INC PI CHAMPAIGN PA 1607 N MARKET ST, PO BOX 5076, CHAMPAIGN, IL 61820-2200 USA SN 1526-484X J9 INT J SPORT NUTR EXE JI Int. J. Sport Nutr. Exerc. Metab. PD DEC PY 2012 VL 22 IS 6 BP 412 EP 421 PG 10 WC Nutrition & Dietetics; Sport Sciences SC Nutrition & Dietetics; Sport Sciences GA 055NC UT WOS:000312422600003 PM 22805150 ER PT J AU O'Fallon, KS Kaushik, D Michniak-Kohn, B Dunne, CP Zambraski, EJ Clarkson, PM AF O'Fallon, Kevin S. Kaushik, Diksha Michniak-Kohn, Bozena Dunne, C. Patrick Zambraski, Edward J. Clarkson, Priscilla M. TI Effects of Quercetin Supplementation on Markers of Muscle Damage and Inflammation After Eccentric Exercise SO INTERNATIONAL JOURNAL OF SPORT NUTRITION AND EXERCISE METABOLISM LA English DT Article DE flavonoid; muscle soreness; DOMS; strength loss ID OXIDATIVE STRESS; ELBOW FLEXORS; MEDIATORS; RECOVERY; HUMANS AB The flavonoid quercetin is purported to have potent antioxidant and anti-inflammatory properties. This study examined if quercetin supplementation attenuates indicators of exercise-induced muscle damage in a double-blind laboratory study. Thirty healthy subjects were randomized to quercetin (QU) or placebo (PL) supplementation and performed 2 separate sessions of 24 eccentric contractions of the elbow flexors. Muscle strength, soreness, resting arm angle, upper arm swelling, serum creatine kinase (CK) activity, plasma quercetin (PQ), interleukin-6 (IL-6), and C-reactive protein (CRP) were assessed before and for 5 d after exercise. Subjects then ingested nutrition bars containing 1,000 mg/d QU or PL for 7 d before and 5 d after the second exercise session, using the opposite arm. PQ reached 202 +/- 52 ng/ml after 7 d of supplementation and remained elevated during the 5-d postexercise recovery period (p < .05). Subjects experienced strength loss (peak = 47%), muscle soreness (peak = 39 +/- 6 mm), reduced arm angle (-7 degrees +/- 1 degrees), CK elevations (peak = 3,307 +/- 1,481 U/L), and arm swelling (peak = 11 +/- 2 mm; p < .0001), indicating muscle damage and inflammation; however, differences between treatments were not detected. Eccentric exercise did not alter plasma IL-6 (peak = 1.9 pg/ml) or CRP (peak = 1.6 mg/L) relative to baseline or by treatment. QU supplementation had no effect on markers of muscle damage or inflammation after eccentric exercise of the elbow flexors. C1 [O'Fallon, Kevin S.; Clarkson, Priscilla M.] Univ Massachusetts, Dept Kinesiol, Amherst, MA 01003 USA. [Kaushik, Diksha; Michniak-Kohn, Bozena] Rutgers State Univ, Dept Pharmaceut, Piscataway, NJ USA. [Dunne, C. Patrick] USA, Natick Soldier RDEC, Combat Feeding Directorate, Natick, MA 01760 USA. [Zambraski, Edward J.] USA, Mil Performance Div, Environm Med Res Inst, Natick, MA 01760 USA. RP O'Fallon, KS (reprint author), Univ Massachusetts, Dept Kinesiol, Amherst, MA 01003 USA. FU U.S. Army [W911QY-07-C-0001] FX This study was funded by the U.S. Army, contract # W911QY-07-C-0001. The authors would like to thank Brittany Rahmberg, James Webb, Trent Ainsworth, Himanshu Shah, and Ahmed Sandakli for their assistance in the laboratory and Dr. Christer Maim for his critical review during the manuscript preparation. None of the authors claim a conflict of interest. NR 27 TC 15 Z9 15 U1 5 U2 12 PU HUMAN KINETICS PUBL INC PI CHAMPAIGN PA 1607 N MARKET ST, PO BOX 5076, CHAMPAIGN, IL 61820-2200 USA SN 1526-484X J9 INT J SPORT NUTR EXE JI Int. J. Sport Nutr. Exerc. Metab. PD DEC PY 2012 VL 22 IS 6 BP 430 EP 437 PG 8 WC Nutrition & Dietetics; Sport Sciences SC Nutrition & Dietetics; Sport Sciences GA 055NC UT WOS:000312422600005 PM 22805422 ER PT J AU McLellan, TM Lieberman, HR AF McLellan, Tom M. Lieberman, Harris R. TI Do energy drinks contain active components other than caffeine? SO NUTRITION REVIEWS LA English DT Review DE guarana; physical and cognitive performance; Red Bull; taurine ID GUARANA PAULLINIA-CUPANA; IMPROVED COGNITIVE PERFORMANCE; PROLONGED STRENUOUS EXERCISE; FOLIC-ACID SUPPLEMENTATION; EPHEDRA-FREE XENADRINE; BLOOD-BRAIN-BARRIER; ENDURANCE PERFORMANCE; ILEX-PARAGUARIENSIS; TAURINE SUPPLEMENTATION; SUBSTRATE METABOLISM AB Energy drinks (EDs) contain caffeine and are a new, popular category of beverage. It has been suggested that EDs enhance physical and cognitive performance; however, it is unclear whether the claimed benefits are attributable to components other than caffeine. A typical 235?mL ED provides between 40 and 250?mg of caffeine, equating to doses that improve cognitive and, at the higher levels, physical performance. EDs often contain taurine, guarana, ginseng, glucuronolactone, B-vitamins, and other compounds. A literature search using PubMed, Psych Info, and Google Scholar identified 32 articles that examined the effects of ED ingredients alone and/or in combination with caffeine on physical or cognitive performance. A systematic evaluation of the evidence-based findings in these articles was then conducted. With the exception of some weak evidence for glucose and guarana extract, there is an overwhelming lack of evidence to substantiate claims that components of EDs, other than caffeine, contribute to the enhancement of physical or cognitive performance. Additional well-designed, randomized, placebo-controlled studies replicated across laboratories are needed in order to assess claims made for these products. C1 [McLellan, Tom M.] TM McLellan Res Inc, Stouffville, ON L4A 8A7, Canada. [Lieberman, Harris R.] USA, Environm Med Res Inst, Mil Nutr Div, Natick, MA 01760 USA. RP McLellan, TM (reprint author), TM McLellan Res Inc, 25 Dorman Dr, Stouffville, ON L4A 8A7, Canada. EM DrTom.McLellan@gmail.com FU US Army Medical Research and Materiel Command (USAMRMC); Department of Defense Center Alliance for Dietary Supplements Research; Oak Ridge Institute for Science and Education FX This work was supported by the US Army Medical Research and Materiel Command (USAMRMC) and the Department of Defense Center Alliance for Dietary Supplements Research. The views, opinions, and/or findings in this report are those of the authors and should not be construed as an official Department of the Army position, policy, or decision, unless so designated by other official documentation. Citation of commercial organization and trade names in this report do not constitute an official Department of the Army endorsement or approval of the products or services of these organizations.; T.M. McLellan was supported by the Oak Ridge Institute for Science and Education through an interagency agreement between the U. S. Department of Energy and USAMRMC. NR 132 TC 34 Z9 35 U1 2 U2 97 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0029-6643 J9 NUTR REV JI Nutr. Rev. PD DEC PY 2012 VL 70 IS 12 BP 730 EP 744 DI 10.1111/j.1753-4887.2012.00525.x PG 15 WC Nutrition & Dietetics SC Nutrition & Dietetics GA 052RV UT WOS:000312216900005 PM 23206286 ER PT J AU Beer, JMA Freeman, DA AF Beer, Jeremy M. A. Freeman, David A. TI Lasers' Spectral and Temporal Profile Can Affect Visual Glare Disability SO AVIATION SPACE AND ENVIRONMENTAL MEDICINE LA English DT Article DE visual disability; laser glare; speckle; wavelength; contrast sensitivity; cognitive interference; dazzler; disruption ID CONTRAST SENSITIVITY FUNCTION; BRIGHTNESS ENHANCEMENT; LIGHT SCATTER; TIME-COURSE; PERFORMANCE; WAVELENGTH; ACCOMMODATION; SIMULATIONS; THRESHOLD; LUMINANCE AB BEER JMA, FREEMAN DA. Lasers' spectral and temporal profile can affect visual glare disability. Aviat Space Environ Med 2012; 83:1135-44. Introduction: Experiments measured the effects of laser glare on visual orientation and motion perception. Laser stimuli were varied according to spectral composition and temporal presentation as subjects identified targets tilt (Experiment 1) and movement (Experiment 2). The objective was to determine whether the glare parameters would alter visual disruption. Methods: Three spectral profiles (monochromatic Green vs. polychromatic White vs. alternating Red-Green) were used to produce a ring of laser glare surrounding a target. Two experiments were performed to measure the minimum contrast required to report target orientation or motion direction. The temporal glare profile was also varied: the ring was illuminated either continuously or discontinuously. Time-averaged luminance of the glare stimuli was matched across all conditions. Results: In both experiments, threshold (Delta L) values were approximately 0.15 log units higher in monochromatic Green than in polychromatic White conditions. In Experiment 2 (motion identification), thresholds were approximately 0.17 log units higher in rapidly flashing (6, 10, or 14 Hz) than in continuous exposure conditions. Discussion: Monochromatic extended-source laser glare disrupted orientation and motion identification more than polychromatic glare. In the motion task, pulse trains faster than 6 Hz (but below flicker fusion) elevated thresholds more than continuous glare with the same time-averaged luminance. Under these conditions, alternating the wavelength of monochromatic glare over time did not aggravate disability relative to green-only glare. Repetitively flashing monochromatic laser glare induced occasional episodes of impaired motion identification, perhaps resulting from cognitive interference. Interference speckle might play a role in aggravating monochromatic glare effects. C1 [Beer, Jeremy M. A.; Freeman, David A.] USA, Med Res Unit San Antonio, Ft Sam Houston, TX 78234 USA. [Beer, Jeremy M. A.; Freeman, David A.] Henry M Jackson Fdn Adv Mil Med, Ft Sam Houston, TX USA. RP Beer, JMA (reprint author), USA, Med Res Unit San Antonio, 3650 Chambers Pass, Ft Sam Houston, TX 78234 USA. EM jeremy.m.beer.ngo@mail.mil FU U.S. Marine Corps Systems Command; U.S. Air Force Research Laboratory Biobehavioral Effects Branch; U.S. Navy [G1105] FX This research was supported by the U.S. Marine Corps Systems Command and the U.S. Air Force Research Laboratory Biobehavioral Effects Branch. It was funded under U.S. Navy Work Unit Number G1105. The authors are grateful to Dr. Alan Ashworth and Mr. Jimmy Fleming (AFRL/RHDJ) for their facilitation of program support or this project. NR 34 TC 1 Z9 1 U1 1 U2 4 PU AEROSPACE MEDICAL ASSOC PI ALEXANDRIA PA 320 S HENRY ST, ALEXANDRIA, VA 22314-3579 USA SN 0095-6562 J9 AVIAT SPACE ENVIR MD JI Aviat. Space Environ. Med. PD DEC PY 2012 VL 83 IS 12 BP 1135 EP 1144 DI 10.3357/ASEM.3243.2012 PG 10 WC Public, Environmental & Occupational Health; Medicine, General & Internal; Sport Sciences SC Public, Environmental & Occupational Health; General & Internal Medicine; Sport Sciences GA 049KK UT WOS:000311981700003 PM 23316541 ER PT J AU Albertazzi, L Mickler, FM Pavan, GM Salomone, F Bardi, G Panniello, M Amir, E Kang, T Killops, KL Brauchle, C Amir, RJ Hawker, CJ AF Albertazzi, Lorenzo Mickler, Frauke M. Pavan, Giovanni M. Salomone, Fabrizio Bardi, Giuseppe Panniello, Mariangela Amir, Elizabeth Kang, Taegon Killops, Kato L. Braeuchle, Christoph Amir, Roey J. Hawker, Craig J. TI Enhanced Bioactivity of Internally Functionalized Cationic Dendrimers with PEG Cores SO BIOMACROMOLECULES LA English DT Article ID INTRACELLULAR TRAFFICKING; LIVING CELLS; BLOCK-COPOLYMERS; CLICK CHEMISTRY; DRUG-DELIVERY; GENE DELIVERY; THIOL-ENE; BIOCOMPATIBILITY; INTERNALIZATION; NANOPARTICLES AB Hybrid dendritic-linear block copolymers based on a 4-arm poly(ethylene glycol) (PEG) core were synthesized using an accelerated AB(2)/CD2 dendritic growth approach through orthogonal amine/epoxy and thiol-yne chemistries. The biological activity of these 4-arm and the corresponding 2-arm hybrid dendrimers revealed an enhanced, dendritic effect with an exponential increase in cell internalization concomitant with increasing amine end groups and low cytotoxicity. Furthermore, the ability of these hybrid dendrimers to induce endosomal escape combined with their facile and efficient synthesis makes them attractive platforms for gene transfection. The 4-arm-based dendrimer showed significantly improved DNA binding and gene transfection capabilities in comparison with the 2-arm derivative. These results combined with the MD simulation indicate a significant effect of both the topology of the PEG core and the multivalency of these hybrid macromolecules on their DNA binding and delivery capablities. C1 [Albertazzi, Lorenzo; Amir, Elizabeth; Kang, Taegon; Amir, Roey J.; Hawker, Craig J.] Univ Calif Santa Barbara, Mat Res Lab, Santa Barbara, CA 93106 USA. [Albertazzi, Lorenzo; Salomone, Fabrizio; Panniello, Mariangela] Scuola Normale Super Pisa, NEST, I-56127 Pisa, Italy. [Albertazzi, Lorenzo; Salomone, Fabrizio; Panniello, Mariangela] CNR, Ist Nanosci, I-56127 Pisa, Italy. [Albertazzi, Lorenzo; Salomone, Fabrizio; Bardi, Giuseppe; Panniello, Mariangela] Ist Italiano Tecnol, NEST, Ctr Nanotechnol Innovat, I-56127 Pisa, Italy. [Mickler, Frauke M.; Braeuchle, Christoph] Univ Munich, Dept Chem, Ctr NanoSci CeNS, D-81377 Munich, Germany. [Mickler, Frauke M.; Braeuchle, Christoph] CIPSM, D-81377 Munich, Germany. [Pavan, Giovanni M.] Univ Appl Sci So Switzerland SUPSI, Lab Appl Math & Phys LaMFI, Ctr Galleria 2, CH-6928 Manno, Switzerland. [Killops, Kato L.] USA, RDECOM Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. [Amir, Roey J.] Tel Aviv Univ, Fac Exact Sci, Sch Chem, Dept Organ Chem, IL-69978 Tel Aviv, Israel. RP Amir, RJ (reprint author), Univ Calif Santa Barbara, Mat Res Lab, Santa Barbara, CA 93106 USA. EM amirroey@tau.ac.il; hawker@mrl.ucsb.edu RI Bardi, Giuseppe/B-6452-2013; Albertazzi, Lorenzo/E-8323-2013; Pavan, Giovanni M./E-7474-2011; Amir, Roey/N-5041-2015; OI Albertazzi, Lorenzo/0000-0002-6837-0812; Pavan, Giovanni M./0000-0002-3473-8471; Amir, Roey/0000-0002-8502-3302; Mickler, Frauke/0000-0002-2748-9155; Bardi, Giuseppe/0000-0001-9662-3007 FU National Institutes of Health as a Program of Excellence in Nanotechnology [HHSN268201000046C]; Institute for Collaborative Biotechnologies from U.S. Army Research Office [W911NF-07-1-0279, W911NF-09-D-0001]; MRSEC Program of the National Science Foundation through the MRL Central Facilities; Nanoinitiative Munich (NIM); Elitenetzwerk Bayern; Samsung; [SPP1313] FX This material is based on work supported by the National Institutes of Health as a Program of Excellence in Nanotechnology (HHSN268201000046C) (R.J.A., C.J.H.). This work was partially supported by the Institute for Collaborative Biotechnologies through grant numbers W911NF-07-1-0279 and W911NF-09-D-0001 from the U.S. Army Research Office (E.A., K.L.K., C.J.H.), MRSEC Program of the National Science Foundation through the MRL Central Facilities (LA, K.L.K., C.J.H.) the Nanoinitiative Munich (NIM), the Elitenetzwerk Bayern, the SPP1313 and by fellowship support from Samsung (T.K.). NR 39 TC 30 Z9 31 U1 4 U2 95 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1525-7797 J9 BIOMACROMOLECULES JI Biomacromolecules PD DEC PY 2012 VL 13 IS 12 BP 4089 EP 4097 DI 10.1021/bm301384y PG 9 WC Biochemistry & Molecular Biology; Chemistry, Organic; Polymer Science SC Biochemistry & Molecular Biology; Chemistry; Polymer Science GA 050EE UT WOS:000312035000023 PM 23140570 ER PT J AU Taylor, AJ Villines, TC Stanek, EJ AF Taylor, Allen J. Villines, Todd C. Stanek, Eric J. TI Paradoxical progression of atherosclerosis related to low-density lipoprotein reduction and exposure to ezetimibe SO EUROPEAN HEART JOURNAL LA English DT Article DE Atherosclerosis; Risk factors; Lipids ID LDL TREATMENT STRATEGIES; ENDOTHELIAL FUNCTION; CHOLESTEROL ABSORPTION; FAMILIAL HYPERCHOLESTEROLEMIA; SCAVENGER RECEPTOR; MEDIA THICKNESS; CLASS-B; SR-BI; SIMVASTATIN; STATINS AB Aims Ezetimibe reduces low-density lipoprotein cholesterol (LDL-C) but has complex actions on cholesterol transport and metabolism, and thus, LDL-C reduction may not solely define its overall effects. We explored the relationship between treatment effects and cumulative exposure to ezetimibe, with its effects on carotid intimamedia thickness (CIMT) in ARBITER 6-HALTS. Methods and results This analysis includes the 159 patients randomized to ezetimibe within ARBITER 6-HALTS that completed the final imaging endpoint assessment. Eligibility criteria for ARBITER 6-HALTS included known coronary artery disease (CAD) or high risk for coronary heart disease, and treatment with a statin with LDL-C 100 mg/dL and high-density lipoprotein cholesterol 50 or 55 mg/dL for men and women, respectively. The mean CIMT was measured in the far wall of the distal common carotid artery. We analysed the univariate and multivariate relationships of the change in CIMT with baseline characteristics, on-treatment effects, and cumulative ezetimibe exposure (treatment duration dose adherence). Ezetimibe reduced LDL-C from 84 23 to 66 20 mg/dL. No net effect on CIMT was observed (baseline CIMT 0.898 0.151 mm; net change 0.002 mm; P 0.52). There was an inverse relationship between LDL-C and change in CIMT such that greater reductions in LDL-C were associated with greater CIMT progression (r 0.266; P 0.001). Change in CIMT also had univariate associations with baseline LDL-C, triglycerides (TG), high-sensitive C-reactive protein, and systolic blood pressure and was directly associated with the change in TG and inversely associated with the change in high-sensitive C-reactive protein. Multivariable models controlling for change in LDL-C, cumulative ezetimibe exposure, and baseline and on-treatment variables showed that both increased LDL-C reduction (P 0.005) and cumulative drug exposure (P 0.02) were associated with ezetimibe-associated CIMT progression. Conclusion Among CAD and high-risk patients on statin therapy in the ARBITER-6 trial, ezetimibe leads to paradoxical progression of CIMT in association with both greater LDL-C reduction and cumulative drug exposure. These findings may suggest the presence of off-target actions of ezetimibe. C1 [Taylor, Allen J.] Georgetown Univ Hosp, Div Cardiol, Washington, DC 20007 USA. [Villines, Todd C.] Walter Reed Army Med Ctr, Serv Cardiol, Washington, DC 20307 USA. [Stanek, Eric J.] Medco Hlth Solut, Franklin Lakes, NJ USA. RP Taylor, AJ (reprint author), Georgetown Univ Hosp, Div Cardiol, 3800 Reservoir Rd NW, Washington, DC 20007 USA. EM allen.taylor@medstar.net OI Villines, Todd/0000-0003-2674-3702 FU Abbott Pharmaceuticals FX Abbott Pharmaceuticals funded the study via an unrestricted, investigator-initiated research grant administered by the Henry M. Jackson Foundation for the Advancement of Military Medicine, Rockville, MD, USA. Dr. Taylor has received lecture honoraria from Abbott. NR 31 TC 6 Z9 7 U1 0 U2 4 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 0195-668X EI 1522-9645 J9 EUR HEART J JI Eur. Heart J. PD DEC PY 2012 VL 33 IS 23 BP 2939 EP 2945 DI 10.1093/eurheartj/ehs105 PG 7 WC Cardiac & Cardiovascular Systems SC Cardiovascular System & Cardiology GA 051EE UT WOS:000312107200012 PM 22564353 ER PT J AU Rhee, CH Pulskamp, JS Polcawich, RG Oldham, KR AF Rhee, Choong-Ho Pulskamp, Jeffrey S. Polcawich, Ronald G. Oldham, Kenn R. TI Multi-Degree-of-Freedom Thin-Film PZT-Actuated Microrobotic Leg SO JOURNAL OF MICROELECTROMECHANICAL SYSTEMS LA English DT Article DE Actuators; lead zirconate titanate (PZT); piezoelectric devices; robots ID MEMS AB As a novel approach to future microrobotic locomotion, a multi-degree-of-freedom (m-DoF) microrobotic appendage is presented that generates large range of motion (5 degrees-40 degrees) in multiple axes using thin-film lead zirconate titanate (PZT) actuators. Due to the high driving force of PZT thin films and a robust fabrication process, m-DoF legs that retain acceptable payload capacity (similar to 2 mg per leg) are achieved. The fabrication process permits thin-film PZT actuator integration with more complex higher aspect ratio silicon structures than previous related processes, using vertical silicon dioxide barrier trenches formed before PZT deposition to provide robust encapsulation of the silicon during later XeF2 release. Planarization of the barrier trenches avoids detrimental effects on piezoelectric performance from the substrate alteration. Once fabricated, kinematic modeling of compact PZT actuator arrays in prototype leg joints is compared to experimental displacement measurements, demonstrating that piezoelectric actuator and assembled robot leg joint performance can be accurately predicted given certain knowledge of PZT properties and residual stress. Resonant frequencies, associated weight bearing, and power consumption are also obtained. [2012-0041] C1 [Rhee, Choong-Ho; Oldham, Kenn R.] Univ Michigan, Dept Mech Engn, Ann Arbor, MI 48109 USA. [Pulskamp, Jeffrey S.; Polcawich, Ronald G.] USA, Micro & Nano Elect & Mat Branch, Res Lab, Adelphi Lab Ctr, Adelphi, MD 20783 USA. RP Rhee, CH (reprint author), Univ Michigan, Dept Mech Engn, Ann Arbor, MI 48109 USA. EM chrhee@umich.edu; jeffrey.s.pulskamp.civ@mail.mil; ronald.g.polcawich.civ@mail.mil; oldham@umich.edu FU U.S. Army Research Laboratory [W911QX-07-C-0072]; National Science Foundation [CMMI 0954422] FX This work was supported in part by the U.S. Army Research Laboratory under Award W911QX-07-C-0072 and in part by the National Science Foundation under Award CMMI 0954422. Subject Editor G. Stemme. NR 22 TC 7 Z9 7 U1 1 U2 37 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1057-7157 J9 J MICROELECTROMECH S JI J. Microelectromech. Syst. PD DEC PY 2012 VL 21 IS 6 BP 1492 EP 1503 DI 10.1109/JMEMS.2012.2211573 PG 12 WC Engineering, Electrical & Electronic; Nanoscience & Nanotechnology; Instruments & Instrumentation; Physics, Applied SC Engineering; Science & Technology - Other Topics; Instruments & Instrumentation; Physics GA 047QB UT WOS:000311854500029 ER PT J AU Gudimetla, VSR Holmes, RB Riker, JF AF Gudimetla, V. S. Rao Holmes, Richard B. Riker, Jim F. TI Analytical expressions for the log-amplitude correlation function for plane wave propagation in anisotropic non-Kolmogorov refractive turbulence SO JOURNAL OF THE OPTICAL SOCIETY OF AMERICA A-OPTICS IMAGE SCIENCE AND VISION LA English DT Article ID LOW-FREQUENCY RANGE; STAR IMAGE MOTION; ATMOSPHERIC-TURBULENCE; STRATOSPHERIC TURBULENCE; PHASE FLUCTUATIONS; RANDOM-MEDIA; SCINTILLATION; SPECTRUM; STATISTICS; SIMULATION AB An analytical expression for the log-amplitude correlation function for plane wave propagation through anisotropic non-Kolmogorov turbulent atmosphere is derived. The closed-form analytic results are based on the Rytov approximation. These results agree well with wave optics simulation based on the more general Fresnel approximation as well as with numerical evaluations, for low-to-moderate strengths of turbulence. The new expression reduces correctly to the previously published analytic expressions for the cases of plane wave propagation through both nonisotropic Kolmogorov turbulence and isotropic non-Kolmogorov turbulence cases. These results are useful for understanding the potential impact of deviations from the standard isotropic Kolmogorov spectrum. (C) 2012 Optical Society of America C1 [Gudimetla, V. S. Rao] USA, Res Lab, Directed Energy Directorate, Kihei, HI 96753 USA. [Holmes, Richard B.] Boeing LTS, Kihei, HI 96753 USA. [Riker, Jim F.] USA, Res Lab, Space Vehicles Directorate, Kirtland AFB, NM 87011 USA. RP Gudimetla, VSR (reprint author), USA, Res Lab, Directed Energy Directorate, 15,535 Lipoa Pkwy,200, Kihei, HI 96753 USA. FU Air Force Office of Scientific Research (AFOSR) FX This work was funded as a Laboratory Research Initiation Request by the Air Force Office of Scientific Research (AFOSR) to Rao Gudimetla as principal investigator. The views expressed in this paper are those of the authors and do not necessarily represent the views of the Department of Defense or its components. Use of computer resources at Maui High Performance Computer Center is acknowledged. NR 45 TC 20 Z9 21 U1 0 U2 7 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1084-7529 EI 1520-8532 J9 J OPT SOC AM A JI J. Opt. Soc. Am. A-Opt. Image Sci. Vis. PD DEC PY 2012 VL 29 IS 12 BP 2622 EP 2627 PG 6 WC Optics SC Optics GA 049NL UT WOS:000311989700014 PM 23455912 ER PT J AU Kragh, JF Cooper, A Aden, JK Dubick, MA Baer, DG Wade, CE Blackbourne, LH AF Kragh, John F., Jr. Cooper, Arthur Aden, James K. Dubick, Michael A. Baer, David G. Wade, Charles E. Blackbourne, Lorne H. TI Survey of Trauma Registry Data on Tourniquet Use in Pediatric War Casualties SO PEDIATRIC EMERGENCY CARE LA English DT Article DE first aid; resuscitation; damage control; hemorrhage; shock ID OPERATION IRAQI FREEDOM; MAJOR LIMB TRAUMA; ENDURING FREEDOM; AFGHANISTAN; WOUNDS AB Objectives: Previously, we reported on the use of emergency tourniquets to stop bleeding in war casualties, but virtually all the data were from adults. Because no pediatric-specific cohort of casualties receiving emergency tourniquets existed, we aimed to fill knowledge gaps on the care and outcomes of this group by surveying data from a trauma registry to refine device designs and clinical training. Methods: A retrospective review of data from a trauma registry yielded an observational cohort of 88 pediatric casualties at US military hospitals in theater on whom tourniquets were used from May 17, 2003, to December 25, 2009. Results: Of the 88 casualties in the study group, 72 were male and 16 were female patients. Ages averaged 11 years (median, 11 years; range, 4-17 years). There were 7 dead and 81 survivor outcomes for a trauma survival rate of 93%. Survivor and dead casualties were similar in all independent variables measured except hospital stay duration (median, 5 days and 1 day, respectively). Six casualties (7%) had neither extremity nor external injury in that they had no lesion indicating tourniquet use. Conclusions: The survival rate of the present study's casualties is similar to that of 3 recent large nonpediatric-specific studies. Although current emergency tourniquets were ostensibly designed for modern adult soldiers, tourniquet makers, perhaps unknowingly, produced tourniquets that fit children. The rate of unindicated tourniquets, 7%, implied that potential users need better diagnostic training. Levels of Evidence: Level 4; case series, therapeutic study. C1 [Kragh, John F., Jr.; Aden, James K.; Dubick, Michael A.; Baer, David G.; Blackbourne, Lorne H.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Kragh, John F., Jr.] Uniformed Serv Univ Hlth Sci, F Edward Hebert Sch Med, Bethesda, MD 20814 USA. [Cooper, Arthur] Columbia Univ, Coll Phys & Surg, Dept Surg, Harlem Hosp Ctr, New York, NY USA. [Wade, Charles E.] Univ Texas Hlth Sci Ctr Houston, Houston, TX USA. RP Kragh, JF (reprint author), USA, Inst Surg Res, 3698 Chambers Pass,Bldg BHT2,Room 222-4, Ft Sam Houston, TX 78234 USA. EM john.kragh1@us.army.mil FU US Army Institute of Surgical Research FX Dr Kragh is an employee of the US Government and receives institutional support through the place where he works, the US Army Institute of Surgical Research. He has consulted at no cost with M2, Inc; Tiger Tourniquet, LLC; Tactical Medical Solutions, LLC; Combat Medical Systems, Inc; Composite Resources Inc; Delfi Medical Innovations, Inc; North American Rescue Products LLC; H & H Associates, Inc; Creative & Effective Technologies, Inc; TEMS Solutions, LLC; Blackhawk Products Group; Hemaclear; Tactical Development Group; Compression Works, LLC; Tier-One Quality Solutions; Kforce Government Solutions; CHI Systems; and Entrotech, Inc. He has received honoraria for work for the Food and Drug Administration for a device consultation. He has received honoraria for trustee work for the nonprofit Musculoskeletal Transplant Foundation. He has worked as a technical representative to the US Government's contracting officer in agreements with Physical Optics Corporation; Resodyn Corporation; International Heart Institute of Montana Foundation; Daemen College; Noble Biomaterials, Inc; Wake Forest Institute of Regenerative Medicine; National Tissue Engineering Center; Pittsburgh Tissue Engineering Initiative; University of Texas Southwestern Medical Center; Arteriocyte, Inc; and Kelly Space and Technology, Inc. For the remaining authors none were declared. This project was funded with internal US Army Institute of Surgical Research funds and not from any of the following organizations: National Institutes of Health, Wellcome Trust, Howard Hughes Medical Institute, or other. NR 16 TC 15 Z9 15 U1 0 U2 4 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0749-5161 J9 PEDIATR EMERG CARE JI Pediatr. Emerg. Care PD DEC PY 2012 VL 28 IS 12 BP 1361 EP 1365 DI 10.1097/PEC.0b013e318276c260 PG 5 WC Emergency Medicine; Pediatrics SC Emergency Medicine; Pediatrics GA 049TG UT WOS:000312005700018 PM 23187998 ER PT J AU Drake, B Paterson, R Tabin, G Butler, FK Cushing, T AF Drake, Brandy Paterson, Ryan Tabin, Geoffrey Butler, Frank K., Jr. Cushing, Tracy TI Wilderness Medical Society Practice Guidelines for Treatment of Eye Injuries and Illnesses in the Wilderness SO WILDERNESS & ENVIRONMENTAL MEDICINE LA English DT Article ID ACUTE BACTERIAL CONJUNCTIVITIS; HIGH-ALTITUDE; REFRACTIVE SURGERY; TRAUMATIC HYPHEMA; CORNEAL THICKNESS; RED EYE; MANAGEMENT; MOUNTAINEERS; ANTIBIOTICS; HEMORRHAGE AB A panel convened to develop an evidence-based set of guidelines for the recognition and treatment of eye injuries and illnesses that may occur in the wilderness. These guidelines are meant to serve as a tool to help wilderness providers accurately identify and subsequently treat or evacuate for a variety of ophthalmologic complaints. Recommendations are graded based on the quality of their supporting evidence and the balance between risks and benefits according to criteria developed by the American College of Chest Physicians. C1 [Drake, Brandy; Paterson, Ryan; Cushing, Tracy] Univ Colorado, Sch Med, Denver Hlth Med Ctr, Denver, CO 80202 USA. [Tabin, Geoffrey] Univ Utah, Sch Med, Salt Lake City, UT USA. [Butler, Frank K., Jr.] USA, Inst Surg Res, Comm Tact Combat Casualty Care, Def Board, Ft Sam Houston, TX 78234 USA. RP Drake, B (reprint author), Univ Colorado, Sch Med, Denver Hlth Med Ctr, Denver, CO 80202 USA. EM brandy.drake@ucdenver.edu NR 58 TC 2 Z9 3 U1 0 U2 4 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1080-6032 J9 WILD ENVIRON MED JI Wildern. Environ. Med. PD WIN PY 2012 VL 23 IS 4 BP 325 EP 336 PG 12 WC Public, Environmental & Occupational Health; Sport Sciences SC Public, Environmental & Occupational Health; Sport Sciences GA 048MD UT WOS:000311914700005 PM 23158204 ER PT J AU Cheng, SF Dastjerdi, MH Ferrari, G Okanobo, A Bower, KS Ryan, DS Amparo, F Stevenson, W Hamrah, P Nallasamy, N Dana, R AF Cheng, Sheng-Fu Dastjerdi, Mohammad H. Ferrari, Giulio Okanobo, Andre Bower, Kraig S. Ryan, Denise S. Amparo, Francisco Stevenson, William Hamrah, Pedram Nallasamy, Nambi Dana, Reza TI Short-Term Topical Bevacizumab in the Treatment of Stable Corneal Neovascularization SO AMERICAN JOURNAL OF OPHTHALMOLOGY LA English DT Article ID ENDOTHELIAL GROWTH-FACTOR; MACULAR DEGENERATION; AVASTIN; ANGIOGENESIS; RANIBIZUMAB; EFFICACY; RECEPTOR; VESSELS; CANCER; VEGF AB center dot PURPOSE: To evaluate the safety and efficacy of topical bevacizumab in the treatment of corneal neovascularization. center dot DESIGN: Prospective, nonrandomized, interventional case series. center dot METHODS: SETTING: Institutional, multicenter clinical trial. STUDY POPULATION: Twenty eyes from 20 patients with stable corneal neovascularization. INTERVENTION PROCEDURES: Patients were treated with topical 1.0% bevacizumab for 3 weeks and were monitored for a total of 24 weeks. MAIN OUTCOME MEASURES: Primary outcome measures included: neovascular area, defined as the area of the corneal vessels themselves; vessel caliber, defined as the mean corneal vessel diameter; and invasion area, defined as the fraction of the total cornea into which the vessels extended. The occurrence of ocular and systemic adverse events was monitored closely. center dot RESULTS: As compared with the baseline visit, patients exhibited a statistically significant improvement in neovascular area by week 6 (P = .007) and in vessel caliber by week 12 (P = .006). At the final visit, neovascular area, vessel caliber, and invasion area were reduced by 47.5%, 36.2%, and 20%, respectively. The decreases in neovascular area and vessel caliber were statistically significant (P < .001 and P = .003, respectively); however, the reduction in invasion area did not reach statistical significance (P = .06). There were no significant changes in the secondary outcomes, and there were no adverse events. center dot CONCLUSIONS: Short-term topical bevacizumab treatment reduced the extent of stable corneal neovascularization as measured by neovascular area and vessel caliber with no associated adverse events. Interestingly, the degree of treatment efficacy was inversely proportional to the baseline invasion area. (Am J Ophthalmol 2012;154:940-948. (C) 2012 by Elsevier Inc. All rights reserved.) C1 [Cheng, Sheng-Fu; Dastjerdi, Mohammad H.; Ferrari, Giulio; Okanobo, Andre; Amparo, Francisco; Stevenson, William; Hamrah, Pedram; Nallasamy, Nambi; Dana, Reza] Harvard Univ, Massachusetts Eye & Ear Infirm, Cornea Serv, Dept Ophthalmol,Sch Med, Boston, MA 02114 USA. [Cheng, Sheng-Fu] Shin Kong Wu Ho Su Mem Hosp, Dept Ophthalmol, Taipei, Taiwan. [Bower, Kraig S.] Johns Hopkins Sch Med, Wilmer Eye Inst, Div Cornea Cataract & External Dis, Baltimore, MD USA. [Ryan, Denise S.] Walter Reed Army Med Ctr, Ophthalmol Serv, Washington, DC 20307 USA. RP Dana, R (reprint author), Harvard Univ, Massachusetts Eye & Ear Infirm, Cornea Serv, Dept Ophthalmol,Sch Med, 243 Charles St, Boston, MA 02114 USA. EM reza_dana@meei.harvard.edu RI ferrari, giulio/J-9260-2016 OI ferrari, giulio/0000-0001-6474-9908 FU National Institutes of Health, Bethesda, Maryland [K24 EY019098]; Prevent Blindness America, Chicago, Illinois FX ALL AUTHORS HAVE COMPLETED AND SUBMITTED THE ICMJE FORM FOR DISCLOSURE OF POTENTIAL CONFLICTS OF interest and none were reported. Supported in part by Grant K24 EY019098 from the National Institutes of Health, Bethesda, Maryland; and by Prevent Blindness America, Chicago, Illinois. Involved in Design of study (M.H.D., RD.); Conduct of study (S.-F.C., M.H.D., K.S.B., R.D.); Collection of data (K.S.B., PH., R.D.); Management, analysis, and interpretation of data (S.-F.C., M.H.D., G.F., A.O., D.S.R., F.A., W.S., N.N., R.D.); and Preparation of manuscript (S.-F.C., W.S., R.D).). This was a prospective protocol-driven study approved by the institutional review boards of the Massachusetts Eye & Ear Infirmary and Walter Reed Army Medical Center. The study also complied with the Health Insurance Portability and Accountability Act. Informed consent was obtained from all patients before enrollment. The clinical trial was registered (registration no.: NCT00559936) and can be accessed on the web site www.clinicaltrials.gov. The authors thank Leila Smaga, Massachusetts Eye & Ear Infirmary, for her invaluable support in the clinical trial management. NR 31 TC 15 Z9 16 U1 0 U2 8 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0002-9394 J9 AM J OPHTHALMOL JI Am. J. Ophthalmol. PD DEC PY 2012 VL 154 IS 6 BP 940 EP 948 DI 10.1016/j.ajo.2012.06.007 PG 9 WC Ophthalmology SC Ophthalmology GA 047ZA UT WOS:000311878800005 PM 22967868 ER PT J AU Armistead-Jehle, P Buican, B AF Armistead-Jehle, Patrick Buican, Brett TI Evaluation Context and Symptom Validity Test Performances in a US Military Sample SO ARCHIVES OF CLINICAL NEUROPSYCHOLOGY LA English DT Article DE Symptom Validity Testing; Response Bias; Word Memory Test; Military ID TRAUMATIC BRAIN-INJURY; RESPONSE BIAS SCALE; NEUROPSYCHOLOGICAL TEST-PERFORMANCE; PERSONALITY-ASSESSMENT INVENTORY; SELF-REPORTED SYMPTOMS; MEMORY IMPAIRMENT; DEMENTIA PROFILE; CLINICAL-SAMPLE; TEST FAILURE; POOR EFFORT AB The study examined Symptom Validity Test (SVT) performance in a sample of military service members on active orders as a function of evaluation context. Service members were assessed in the context of either a pending disability evaluation (Medical Evaluation Board; MEB) or a non-MEB/clinical evaluation. Overall, 41.8 of the sample failed the Word Memory Test; however, significantly more individuals in the MEB group (54) failed the measure relative to the non-MEB/clinical group (35). Regardless of group membership, SVT performance had a notable impact on neurocognitive test scores as measured by effect sizes. SVT performance was less strongly associated with self-reported psychological symptoms as gauged by the Personality Assessment Inventory. The current results are discussed in light of previous research on SVT performance in veteran and active duty samples. C1 [Armistead-Jehle, Patrick] Munson Army Hlth Ctr, Dept Behav Hlth, Ft Leavenworth, KS 66027 USA. [Buican, Brett] Ireland Army Community Hosp, Traumat Brain Injury Clin, Ft Knox, KY USA. RP Armistead-Jehle, P (reprint author), Munson Army Hlth Ctr, Dept Behav Hlth, 550 Pope Ave, Ft Leavenworth, KS 66027 USA. EM patrick.jehle@amedd.army.mil NR 62 TC 18 Z9 18 U1 2 U2 9 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 0887-6177 J9 ARCH CLIN NEUROPSYCH JI Arch. Clin. Neuropsychol. PD DEC PY 2012 VL 27 IS 8 BP 828 EP 839 DI 10.1093/arclin/acs086 PG 12 WC Psychology, Clinical; Psychology SC Psychology GA 044RO UT WOS:000311641000002 PM 23047953 ER PT J AU Dennis, CJ Chung, KK Holland, SR Yoon, BS Milligan, DJ Nitzschke, SL Maani, CV Hansen, JJ Aden, JK Renz, EM AF Dennis, Christopher J. Chung, Kevin K. Holland, Seth R. Yoon, Brian S. Milligan, Daun J. Nitzschke, Stephanie L. Maani, Christopher V. Hansen, Jacob J. Aden, James K. Renz, Evan M. TI Risk factors for hypotension in urgently intubated burn patients SO BURNS LA English DT Article DE Burns; Intubation; Propofol; Induction; Respiratory failure; Critical care ID ANESTHESIA; INDUCTION; PROPOFOL AB Background: When urgently intubating patient in the burn intensive care unit (BICU), various induction agents, including propofol, are utilized that may induce hemodynamic instability. Methods: A retrospective review was performed of consecutive critically ill burn patients who underwent urgent endotracheal intubation in BICU. Basic bum-related demographic data, indication for intubation, and induction agents utilized were recorded. The primary outcomes of interest were clinically significant hypotension requiring immediate fluid resuscitation, initiation or escalation of vasopressors immediately after intubation. Secondary outcomes included ventilator days, stay length, and in-hospital mortality. Results: Between January 2003 and August 2010, we identified 279 urgent intubations in 204 patients. Of these, the criteria for presumed sepsis were met in 60% (n = 168) of the intubations. After intubation, 117 patients (42%) experienced clinically significant hypotension. Propofol (51%) was the most commonly utilized induction agent followed by etomidate (23%), ketamine (15%), and midazolam (11%). On multiple logistic regression, %TBSA (OR 1.016, 95% CI 1.004-1.027, p < 0.001) and presumed sepsis (OR 1.852, 95% CI 1.100-3.117, p = 0.02) were the only significant predictors of hypotension. None of the induction agents, including propofol, were significantly associated with hypotension in patients with or without presumed sepsis. Conclusions: In critically ill burn patients undergoing urgent endotracheal intubation, specific induction agents, including propofol, were not associated with clinically significant hypotension. Presumed sepsis and %TBSA were the most important risk factors. Published by Elsevier Ltd and ISBI. C1 [Chung, Kevin K.; Nitzschke, Stephanie L.; Maani, Christopher V.; Hansen, Jacob J.; Aden, James K.; Renz, Evan M.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Dennis, Christopher J.; Holland, Seth R.; Milligan, Daun J.] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. [Yoon, Brian S.] William Beaumont Army Med Ctr, El Paso, TX 79920 USA. RP Chung, KK (reprint author), USA, Inst Surg Res, 3698 Chambers Pass, Ft Sam Houston, TX 78234 USA. EM Kevin.chung@us.army.mil FU Clinical Trials Task Area of the United States Army Institute of Surgical Research FX This project was funded by the Clinical Trials Task Area of the United States Army Institute of Surgical Research. NR 13 TC 3 Z9 3 U1 0 U2 0 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0305-4179 J9 BURNS JI Burns PD DEC PY 2012 VL 38 IS 8 BP 1181 EP 1185 DI 10.1016/j.burns.2012.07.004 PG 5 WC Critical Care Medicine; Dermatology; Surgery SC General & Internal Medicine; Dermatology; Surgery GA 046OM UT WOS:000311774300013 PM 22884966 ER PT J AU Smith, A Doan, ML Roy, D Pinsker, JE AF Smith, Ashley Doan, Minh L. Roy, Daniel Pinsker, Jordan E. TI Adrenal Insufficiency and Growth Failure Secondary to Inhaled Corticosteroids: A Paradoxical Complication SO CLINICAL PEDIATRICS LA English DT Article ID ASTHMATIC-CHILDREN; AXIS SUPPRESSION; BUDESONIDE; THERAPY C1 [Pinsker, Jordan E.] Tripler Army Med Ctr, Dept Pediat, Div Pediat Endocrinol, Mail Code MCHK PE, Honolulu, HI 96859 USA. RP Pinsker, JE (reprint author), Tripler Army Med Ctr, Dept Pediat, Div Pediat Endocrinol, Mail Code MCHK PE, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM jordan.pinsker@us.army.mil OI Pinsker, Jordan/0000-0003-4080-9034 NR 10 TC 0 Z9 0 U1 0 U2 6 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0009-9228 J9 CLIN PEDIATR JI Clin. Pediatr. PD DEC PY 2012 VL 51 IS 12 BP 1194 EP 1196 DI 10.1177/0009922812437932 PG 3 WC Pediatrics SC Pediatrics GA 046HZ UT WOS:000311757400013 PM 22387925 ER PT J AU Samy, RP Gopalakrishnakone, P Stiles, BG Girish, KS Swamy, SN Hemshekhar, M Tan, KS Rowan, EG Sethi, G Chow, VTK AF Samy, R. P. Gopalakrishnakone, P. Stiles, B. G. Girish, K. S. Swamy, S. N. Hemshekhar, M. Tan, K. S. Rowan, E. G. Sethi, G. Chow, V. T. K. TI Snake Venom Phospholipases A(2): A Novel Tool Against Bacterial Diseases SO CURRENT MEDICINAL CHEMISTRY LA English DT Review DE Bactericidal activity; catalytic activity; gram-negative; gram-positive; lipopolysaccharide (LPS); phospholipases A(2)s (PLA(2)s) ID MEMBRANE-DAMAGING ACTIVITY; PERMEABILITY-INCREASING PROTEIN; BOTHROPS-JARARACUSSU VENOM; AGKISTRODON-HALYS-PALLAS; PH-INDUCED DISSOCIATION; GRAM-POSITIVE BACTERIA; C-TERMINAL REGION; ANTIMICROBIAL PEPTIDES; CRYSTAL-STRUCTURE; MYOTOXIN-II AB The majority of snake venom phospholipases A(2) (svPLA(2)s) are toxic and induce a wide spectrum of biological effects. They are cysteine-rich proteins that contain 119-134 amino acids and share similar structures and functions. About 50% of the residues are incorporated into alpha-helices, whereas only 10% are in beta-sheets. Fourteen conserved cysteines form a network of seven disulfide bridges that stabilize the tertiary structure. They show a high degree of sequence and structural similarity, and are believed to have a common calcium-dependent catalytic mechanism. Additionally, svPLA(2)s display an array of biological actions that are either dependent or independent of catalysis. The PLA(2)s of mammalian origin also exert potent bactericidal activity by binding to anionic surfaces and enzymatic degradation of phospholipids in the target membranes, preferentially of Gram-positive species. The bactericidal activity against Gram-negatives by svPLA(2) requires a synergistic action with bactericidal/permeability-increasing protein (BPI), but is equally dependent on enzymatic-based membrane degradation. Several hypotheses account for the bactericidal properties of svPLA(2)s, which include "fatal depolarization" of the bacterial membrane, creation of physical holes in the membrane, scrambling of normal distribution of lipids between the bilayer leaflets, and damage of critical intracellular targets after internalization of the peptide. The present review discusses several svPLA(2)s and derived peptides that exhibit strong bactericidal activity. The reports demonstrate that svPLA(2)-derived peptides have the potential to counteract microbial infections. In fact, the C-terminal cationic/hydrophobic segment (residues 115-129) of svPLA(2)s is bactericidal. Thus identification of the bactericidal sites in svPLA(2)s has potential for developing novel antimicrobials. C1 [Tan, K. S.] Singapore MIT Alliance Res & Technol, Infect Dis Interdisciplinary Res Grp, Singapore, Singapore. [Gopalakrishnakone, P.] Natl Univ Singapore, Natl Univ Hlth Syst, Yong Loo Lin Sch Med, Venom & Toxin Res Programme,Dept Anat, Singapore 117597, Singapore. [Stiles, B. G.] USA, Med Res Inst Infect Dis, Integrated Toxicol Div, Ft Detrick, MD 21702 USA. [Stiles, B. G.] Wilson Coll, Chambersburg, PA 17201 USA. [Girish, K. S.; Hemshekhar, M.] Univ Mysore, Dept Biochem, Mysore 570006, Karnataka, India. [Swamy, S. N.] Sri Jayachamarajendra Coll Engn, Dept Biotechnol, Mysore 570006, Karnataka, India. [Sethi, G.] Natl Univ Singapore, Natl Univ Hlth Syst, Yong Loo Lin Sch Med, Dept Pharmacol, Singapore 117597, Singapore. [Rowan, E. G.] Univ Strathclyde, Strathclyde Inst Pharm & Biomed Sci, Glasgow G4 0RE, Lanark, Scotland. [Samy, R. P.; Tan, K. S.; Chow, V. T. K.] Natl Univ Singapore, Natl Univ Hlth Syst, Yong Loo Lin Sch Med, Dept Microbiol,Infect Dis Programme, Singapore 117597, Singapore. RP Samy, RP (reprint author), Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Microbiol, Infect Dis Programme, Singapore 117597, Singapore. EM rperumalsamy@yahoo.co.uk RI Sethi, Gautam/F-2372-2011 FU Economic Development Board, Singapore [R-181-000-110-144] FX The authors are thankful to the Economic Development Board, Singapore for financial support (Proof of Concept Grant No: R-181-000-110-144). NR 141 TC 14 Z9 16 U1 2 U2 16 PU BENTHAM SCIENCE PUBL LTD PI SHARJAH PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB EMIRATES SN 0929-8673 J9 CURR MED CHEM JI Curr. Med. Chem. PD DEC PY 2012 VL 19 IS 36 BP 6150 EP 6162 PG 13 WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Pharmacology & Pharmacy SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy GA 049CO UT WOS:000311959800007 PM 22963667 ER PT J AU Romano, JM Rosario, D McCarthy, J AF Romano, Joao M. Rosario, Dalton McCarthy, James TI Day/Night Polarimetric Anomaly Detection Using SPICE Imagery SO IEEE TRANSACTIONS ON GEOSCIENCE AND REMOTE SENSING LA English DT Article DE Anomaly detection; longwave infrared (LWIR); polarization; spectral polarimetric imagery collection experimentation (SPICE); thermal ID REMOTE-SENSING APPLICATIONS; MATERIAL CLASSIFICATION; POLARIZATION CAMERA; TARGET DETECTION; REFLECTANCE; SURFACE AB We introduce a novel longwave polarimetric-based approach to man-made object detection that departs from a more traditional direct use of Stokes parameters. The approach exploits the spatial statistics on two coregistered vertical and horizontal polarization components of the images, where differences of spatial second-order statistics in the bivariate space reveal that man-made objects are separable from natural objects while holding invariant to diurnal cycle variation and geometry of illumination. We exploit the invariant feature using the Bayes decision rule based only on probabilities. Experimental results on a challenging data set, covering a 24-h diurnal cycle, show the effectiveness of the new approach on detecting anomalies; three military tank surrogates posed at different aspect angles are detectable in a natural clutter background. These results yield a negligible false alarm rate as the heating components of the tank surrogates were turned off during data collection. C1 [Romano, Joao M.] USA, Armaments Res Dev & Engn ARDEC, Picatinny Arsenal, NJ 07806 USA. [Rosario, Dalton] USA, Res Lab ARL, Adelphi, MD 20783 USA. [McCarthy, James] Def Sci & Technol Org, Edinburgh, SA 5111, Australia. RP Romano, JM (reprint author), USA, Armaments Res Dev & Engn ARDEC, Picatinny Arsenal, NJ 07806 USA. EM joao.m.romano@us.army.mil; dalton.s.rosario.civ@mail.mil; James.Mccarthy@dsto.defence.gov.au FU U.S. Army ARDEC; ARL; Australian DSTO FX This work was supported by the U.S. Army ARDEC, ARL, and the Australian DSTO. NR 43 TC 7 Z9 7 U1 1 U2 12 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0196-2892 J9 IEEE T GEOSCI REMOTE JI IEEE Trans. Geosci. Remote Sensing PD DEC PY 2012 VL 50 IS 12 SI SI BP 5014 EP 5023 DI 10.1109/TGRS.2012.2195186 PG 10 WC Geochemistry & Geophysics; Engineering, Electrical & Electronic; Remote Sensing; Imaging Science & Photographic Technology SC Geochemistry & Geophysics; Engineering; Remote Sensing; Imaging Science & Photographic Technology GA 046UY UT WOS:000311791100018 ER PT J AU Siegel, D Ly, C Lee, J AF Siegel, David Ly, Canh Lee, Jay TI Methodology and Framework for Predicting Helicopter Rolling Element Bearing Failure SO IEEE TRANSACTIONS ON RELIABILITY LA English DT Article DE Bearing envelope analysis; bearing failure prediction; remaining useful life; robust regression ID DIAGNOSTICS; PROGNOSTICS; SELECTION AB The enhanced ability to predict the remaining useful life of helicopter drive train components offers potential improvement in the safety, maintainability, and reliability of a helicopter fleet. Current existing helicopter health and usage monitoring systems provide diagnostic information that indicates when the condition of a drive train component is degraded; however, prediction techniques are not currently used. Although various algorithms exist for providing remaining life predictions, prognostic techniques have not fully matured. This particular study addresses remaining useful life predictions for the helicopter oil-cooler bearings. The paper proposes a general methodology of how to perform rolling element bearing prognostics, and presents the results using a robust regression curve fitting approach. The proposed methodology includes a series of processing steps prior to the prediction routine, including feature extraction, feature selection, and health assessment. This approach provides a framework for including prediction algorithms into existing health and usage monitoring systems. A case study with the data collected by Impact Technology, LLC. is analysed using the proposed methodology. Future work would consider using the same methodology, but comparing the accuracy of this prediction method with Bayesian filtering techniques, usage based methods, and other time series prediction methods. C1 [Siegel, David; Lee, Jay] Univ Cincinnati, NSF Ctr Intelligent Maintenance Syst, Cincinnati, OH 45221 USA. [Ly, Canh] USA, Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA. RP Siegel, D (reprint author), Univ Cincinnati, NSF Ctr Intelligent Maintenance Syst, Cincinnati, OH 45221 USA. FU [W911NF-07-2-0075] FX This work was funded under contract number W911NF-07-2-0075, the experimental testing and data collection were performed by Impact Technologies LLC. Associate Editor: P. Lall. NR 36 TC 16 Z9 16 U1 4 U2 46 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0018-9529 EI 1558-1721 J9 IEEE T RELIAB JI IEEE Trans. Reliab. PD DEC PY 2012 VL 61 IS 4 BP 846 EP 857 DI 10.1109/TR.2012.2220697 PG 12 WC Computer Science, Hardware & Architecture; Computer Science, Software Engineering; Engineering, Electrical & Electronic SC Computer Science; Engineering GA 047MB UT WOS:000311843900002 ER PT J AU Borrelli, J Pape, C Hak, D Hsu, J Lin, S Giannoudis, P Lane, J AF Borrelli, Joseph, Jr. Pape, Chris Hak, David Hsu, Joseph Lin, Sheldon Giannoudis, Peter Lane, Joseph TI Physiological Challenges of Bone Repair SO JOURNAL OF ORTHOPAEDIC TRAUMA LA English DT Review ID FRACTURE; AGE; EXPRESSION; RATS AB Bone healing after fracture occurs in a well-organized manner and involves a multitude of cell types, inflammatory cytokines, growth factors, prostaglandins, and certain vitamins. Some of the means by which alterations in these essential components affect bone repair are understood, whereas others still need to be delineated. Based on clinical experience and basic science research, certain clinical conditions have become associated with delays in bone repair after fracture. These conditions include chronic inflammation, diabetes, hypovitaminosis, aging, and polytrauma. This brief report reviews some of the ways by which these conditions have been shown to negatively influence bone repair. C1 [Borrelli, Joseph, Jr.] Orthoped Med Specialists, Texas Hlth Phys Grp, Arlington, TX 76012 USA. [Pape, Chris] Univ Aachen, Aachen, Germany. [Hak, David] Denver Hlth, Denver, CO USA. [Hsu, Joseph] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Lin, Sheldon] Univ Med & Dent New Jersey, New Jersey Med Sch, Newark, NJ 07103 USA. [Giannoudis, Peter] Acad Dept Trauma & Orthopaed, Leeds, W Yorkshire, England. [Lane, Joseph] Hosp Special Surg, New York, NY 10021 USA. RP Borrelli, J (reprint author), Orthoped Med Specialists, Texas Hlth Phys Grp, McRae Bldg,1st Floor,810 W Randol Mill Rd, Arlington, TX 76012 USA. EM josephborrelli@texashealth.org FU Elsevier; Springer; JOR; Wolters Kluwer Health; Lippincott Williams Wilkins; Stryker; Synthes; AO; Combat Casualty Research Program; Major Extremity Trauma Research Consortium; Geneva Foundation; Clinical Rehabilitative Medicine Research Program; Board, Limb Lengthening and Reconstruction Society; Society of Military Orthopaedic Surgeons; DePuy FX Borrelli: Honoraria, Synthes, Inc; Paid Consultant, RTI, Inc; Royalties: Elsevier, Springer. C. Pape: Paid Consultant, Zimmer; Royalties: JOR, Wolters Kluwer Health, Lippincott Williams & Wilkins, Springer. D. Hak: Consultant, RTI Biologics, Baxter; Expert testimony, Various; Grants, Stryker, Synthes, AO. J. Hsu: Grant, Combat Casualty Research Program, Major Extremity Trauma Research Consortium, The Geneva Foundation, Clinical Rehabilitative Medicine Research Program; Board, Limb Lengthening and Reconstruction Society, Society of Military Orthopaedic Surgeons. S. Lin: Consultancy, Zimmer. P. Giannoudis: Board, Br Orthop Assoc; Consultancy, DePuy, Synthes, Stryker; Grants, Synthes, DePuy; Royalties, DePuy. J. Lane: Consulting Fee-Honorarium, Amgen, Eli Lilly, Warner-Chillcott, Graftys, Bone Therapeutics, BioMimetics, Zimmer; Board member, Zimmer; Consultancy, BioMimetics, Graftys, Amgen, Zimmer. NR 21 TC 6 Z9 7 U1 1 U2 25 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0890-5339 J9 J ORTHOP TRAUMA JI J. Orthop. Trauma PD DEC PY 2012 VL 26 IS 12 BP 708 EP 711 DI 10.1097/BOT.0b013e318274da8b PG 4 WC Orthopedics; Sport Sciences SC Orthopedics; Sport Sciences GA 045TG UT WOS:000311719100009 PM 23047710 ER PT J AU Penn-Barwell, JG Murray, CK Wenke, JC AF Penn-Barwell, Jowan G. Murray, Clinton K. Wenke, Joseph C. TI Comparison of the Antimicrobial Effect of Chlorhexidine and Saline for Irrigating a Contaminated Open Fracture Model SO JOURNAL OF ORTHOPAEDIC TRAUMA LA English DT Article DE open fractures; infection; injury; irrigation; chlorhexidine; antiseptic; lavage; debridement; wounds ID ANTISEPTICS; INFECTION; WOUNDS; KNEE; DISINFECTANTS; SONICATION; DIAGNOSIS; TOXICITY; SOAP AB Objectives: The objective of this study is to compare antimicrobial effect of irrigation with chlorhexidine gluconate (CHG) to saline in an animal model. Methods: This study used a segmental defect rat femur model contaminated with Staphylococcus aureus and treated 6 hours after injury with debridement and irrigation with 60 mL of fluid delivered at low pressure. In study groups of 10 animals each, 3 concentrations of CHG (0.5%, 0.05%, and 0.005%) were used and a group irrigated with 0.05% CHG and then saline and a control group treated with saline only. After irrigation the wounds were closed, and the rats were recovered. Fourteen days later, bone and implants were harvested for separate microbiological analysis. Results: There was no statistical difference detected between the subsequent presence or quantity of bacteria after irrigation, with aqueous CHG at a range of concentrations comparing irrigation with saline alone. Conclusions: This study does not support the use of CHG as an irrigant. This may be due to the antibacterial effect of CHG being offset by the associated host tissue toxicity. Host tissue damage from high irrigation pressures and cytotoxic solutions has been shown to allow bacteria to thrive. We believe this is due to a "rebound" of bacteria growth in a wound bed containing small quantities of necrotic tissue damaged by CHG exposure. C1 [Penn-Barwell, Jowan G.; Wenke, Joseph C.] Royal Ctr Def Med, Acad Dept Mil Surg & Trauma, Birmingham B15 2SQ, W Midlands, England. [Penn-Barwell, Jowan G.] USA, Inst Surg Res, Extrem Trauma Bone Grp, San Antonio, TX USA. [Murray, Clinton K.] Brooke Army Med Ctr, Dept Med, Infect Dis Serv, San Antonio, TX USA. RP Penn-Barwell, JG (reprint author), Royal Ctr Def Med, Acad Dept Mil Surg & Trauma, Birmingham B15 2SQ, W Midlands, England. EM jowan@doctors.net.uk NR 32 TC 11 Z9 11 U1 2 U2 13 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0890-5339 J9 J ORTHOP TRAUMA JI J. Orthop. Trauma PD DEC PY 2012 VL 26 IS 12 BP 728 EP 732 DI 10.1097/BOT.0b013e31826c19c4 PG 5 WC Orthopedics; Sport Sciences SC Orthopedics; Sport Sciences GA 045TG UT WOS:000311719100013 PM 22874117 ER PT J AU Rajaraman, S Ramakrishnan, S Thorsley, D Wesensten, NJ Balkin, TJ Reifman, J AF Rajaraman, Srinivasan Ramakrishnan, Sridhar Thorsley, David Wesensten, Nancy J. Balkin, Thomas J. Reifman, Jaques TI A new metric for quantifying performance impairment on the psychomotor vigilance test SO JOURNAL OF SLEEP RESEARCH LA English DT Article DE cognitive performance; effect size; Jensen-Shannon divergence; psychomotor vigilance test; sleep deprivation; two-process model ID SLEEP-DEPRIVED INDIVIDUALS; 2-PROCESS MODEL; DEPRIVATION; PREDICTION; DYNAMICS; TASK AB We have developed a new psychomotor vigilance test (PVT) metric for quantifying the effects of sleep loss on performance impairment. The new metric quantifies performance impairment by estimating the probability density of response times (RTs) in a PVT session, and then considering deviations of the density relative to that of a baseline-session density. Results from a controlled laboratory study involving 12 healthy adults subjected to 85 h of extended wakefulness, followed by 12 h of recovery sleep, revealed that the group performance variability based on the new metric remained relatively uniform throughout wakefulness. In contrast, the variability of PVT lapses, mean RT, median RT and (to a lesser extent) mean speed showed strong time-of-day effects, with the PVT lapse variability changing with time of day depending on the selected threshold. Our analysis suggests that the new metric captures more effectively the homeostatic and circadian process underlying sleep regulation than the other metrics, both directly in terms of larger effect sizes (461% larger) and indirectly through improved fits to the two-process model (967% larger coefficient of determination). Although the trend of the mean speed results followed those of the new metric, we found that mean speed yields significantly smaller (similar to 50%) intersubject performance variance than the other metrics. Based on these findings, and that the new metric considers performance changes based on the entire set of responses relative to a baseline, we conclude that it provides a number of potential advantages over the traditional PVT metrics. C1 [Rajaraman, Srinivasan; Ramakrishnan, Sridhar; Thorsley, David; Reifman, Jaques] USA, DoD Biotechnol High Performance Comp Software Apl, Telemed & Adv Technol Res Ctr, Med Res & Mat Command, Ft Detrick, MD 21702 USA. [Wesensten, Nancy J.; Balkin, Thomas J.] Walter Reed Army Inst Res, Behav Biol Branch, Ctr Mil Psychiat & Neurosci, Silver Spring, MD USA. RP Reifman, J (reprint author), USA, DoD Biotechnol HPC Software Applicat Inst, Telemed & Adv Technol Res Ctr, Med Res & Mat Command,ATTN MCMR TT, 504 Scott St, Ft Detrick, MD 21702 USA. EM jaques.reifman@us.army.mil FU Military Operational Medicine Research Area Directorate of the US Army Medical Research and Materiel Command, Fort Detrick, MD FX This work was funded, in part, by the Military Operational Medicine Research Area Directorate of the US Army Medical Research and Materiel Command, Fort Detrick, MD. NR 27 TC 6 Z9 6 U1 1 U2 10 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0962-1105 J9 J SLEEP RES JI J. Sleep Res. PD DEC PY 2012 VL 21 IS 6 BP 659 EP 674 DI 10.1111/j.1365-2869.2012.01008.x PG 16 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA 045HS UT WOS:000311686700009 PM 22436093 ER PT J AU Kim, HC Han, SH Dick, CW Choi, YG Chong, ST Klein, TA Rueda, LM AF Kim, Heung Chul Han, Sang Hoon Dick, Carl W. Choi, Yong Gun Chong, Sung Tae Klein, Terry A. Rueda, Leopoldo M. TI Geographical distribution of bat flies (Diptera: Nycteribiidae and Streblidae), including two new records, Nycteribia allotopa and N. formosana, collected from bats (Chiroptera: Rhinolophidae and Vespertilionidae) in the Republic of Korea SO JOURNAL OF VECTOR ECOLOGY LA English DT Article DE Ectoparasites; bats; host relationship; Nycteribia; Penicillidia; Brachytarsina AB As part of the 65th Medical Brigade, U.S. Army, arthropod-borne disease surveillance program and in collaboration with the Korea National Institute of Biological Resources (NIBR), bats were captured from caves and abandoned mines in the Republic of Korea. A total of 39 adult bat flies including five species of Nycteribiidae [Penicillidia jenynsii, Nycteribia parvula, N. formosana, N. allotopa mikado, and an unidentified species of Nycteribia (N. cf. formosana)], and one species of Streblidae, Brachytarsina kanoi, were collected from bats belonging to two families, Rhinolophidae and Vespertilionidae. This is the first report of N. allotopa mikado and N. formosana from the Republic of Korea. C1 [Rueda, Leopoldo M.] Walter Reed Army Inst Res, Walter Reed Biosystemat Unit, Entomol Branch, Silver Spring, MD 20910 USA. [Kim, Heung Chul; Chong, Sung Tae] 65th Med Brigade, Med Detachment 5, Multifunct Med Battal 168, Unit 15247, APO, AP 96205 USA. [Han, Sang Hoon] Natl Inst Biol Resources, Div Vertebrates Res, Inchon 404170, South Korea. [Dick, Carl W.] Western Kentucky Univ, Dept Biol, Bowling Green, KY 42101 USA. [Dick, Carl W.] Field Museum Nat Hist, Dept Zool, Chicago, IL 60605 USA. [Choi, Yong Gun] Yeongwol Cave Ecomuseum, Korean Inst Biospeleol, Yeongwol 230821, Gangwon Provinc, South Korea. [Klein, Terry A.] USA, Med Brigade 65, MEDDAC Korea, Unit 15281, APO, AP 96205 USA. RP Rueda, LM (reprint author), Walter Reed Army Inst Res, Walter Reed Biosystemat Unit, Entomol Branch, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM ruedapol@si.edu RI Valle, Ruben/A-7512-2013 FU AFHSC-Global Emerging Infections Surveillance and Response Systems, Silver Spring, MD; National Center for Military Intelligence, Fort Detrick, MD FX We thank the Dr. Yeon-Soon Ahn, Chief, National Institute of Biological Resources (NIBR), for support in collecting bat ectoparasites. We also thank Dr. Motoyoshi Mogi, Department of Microbiology, Saga Medical School, Japan, and Dr. Joel Gaydos, Armed Forces Health Surveillance Center (AFHSC), Silver Spring, MD, for their support in conducting this work. Part of this work was funded by the AFHSC-Global Emerging Infections Surveillance and Response Systems, Silver Spring, MD, and the National Center for Military Intelligence, Fort Detrick, MD. The views expressed in this article are those of the authors and do not reflect the official policy or position of the Department of Defense, the Department of the Army, or the U.S. Government. NR 10 TC 0 Z9 1 U1 0 U2 9 PU SOC VECTOR ECOLOGY PI CORONA PA 1966 COMPTON AVE, CORONA, CA 92881 USA SN 1081-1710 J9 J VECTOR ECOL JI J. Vector Ecol. PD DEC PY 2012 VL 37 IS 2 BP 333 EP 337 DI 10.1111/j.1948-7134.2012.00235.x PG 5 WC Entomology SC Entomology GA 044FK UT WOS:000311604600011 PM 23181856 ER PT J AU Mehmood, A Damarla, T Sabatier, J AF Mehmood, Asif Damarla, Thyagaraju Sabatier, James TI Separation of human and animal seismic signatures using non-negative matrix factorization SO PATTERN RECOGNITION LETTERS LA English DT Article DE Non negative matrix factorization; Dimensionality reduction; Sparsity; Single channel source separation; Spectrogram ID DECONVOLUTION AB Seismic footstep detection based systems can be employed for homeland security applications such as perimeter protection and the border security. This paper reports an approach based on non-negative matrix factorization (NMF) for seismic footstep signal separation for a single channel recording. A supervised NMF technique is employed to separate the human footstep signatures from the horse footstep signatures. The proposed algorithm is applied on the spectrogram of human footstep signals and horse footstep signals. The spectrograms of these signals are presented as a sum of components, each having a fixed spectrum and time-varying gain. The main benefit of the proposed technique is its ability to decompose a complex signal automatically into objects that have a meaningful interpretation. In this paper, a sparsity-based NMF algorithm is developed and implemented on seismic data of human and horse footsteps. The performance of this method is very promising and is demonstrated by the experimental results. (c) 2012 Elsevier B.V. All rights reserved. C1 [Mehmood, Asif; Damarla, Thyagaraju; Sabatier, James] USA, Res Lab, Adelphi, MD 20783 USA. RP Mehmood, A (reprint author), USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM asif.mehmood1.ctr@mail.mil FU Oak Ridge University Associated (ORAU) postdoctoral program FX This work was completed with the support of Oak Ridge University Associated (ORAU) postdoctoral program.; This research was supported in part by an appointment to the ORAU Postdoctoral Program at Army Research Laboratory administered by Oak Ridge Associated Universities. We are thankful to Brian king and Les Atlas from University of Washington for the valuable discussion on NMF and source separation. NR 29 TC 7 Z9 8 U1 0 U2 6 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0167-8655 J9 PATTERN RECOGN LETT JI Pattern Recognit. Lett. PD DEC 1 PY 2012 VL 33 IS 16 BP 2085 EP 2093 DI 10.1016/j.patrec.2012.06.015 PG 9 WC Computer Science, Artificial Intelligence SC Computer Science GA 039PW UT WOS:000311260000004 ER PT J AU Fritz, JM Childs, JD Wainner, RS Flynn, TW AF Fritz, Julie M. Childs, John D. Wainner, Robert S. Flynn, Timothy W. TI Primary Care Referral of Patients With Low Back Pain to Physical Therapy Impact on Future Health Care Utilization and Costs SO SPINE LA English DT Article DE primary care; physical therapy; health services research ID RANDOMIZED CLINICAL-TRIAL; GEOGRAPHIC-VARIATION; UNITED-STATES; OPIOID USE; MANAGEMENT; DISABILITY; GUIDELINES; OUTCOMES; SURGERY; TRENDS AB Study Design. A retrospective cohort. Objective. To describe physical therapy utilization following primary care consultation for low back pain (LBP) and evaluate associations between the timing and content of physical therapy and subsequent health care utilization and costs. Summary of Background Data. Primary care management of LBP is highly variable and the implications for subsequent costs are not well understood. The importance of referring patients from primary care to physical therapy has been debated, and information on how the timing and content of physical therapy impact subsequent costs and utilization is needed. Methods. Data were extracted from a national database of employer-sponsored health plans. A total of 32,070 patients with a new primary care LBP consultation were identified and categorized on the basis of the use of physical therapy within 90 days. Patients utilizing physical therapy were further categorized based on timing (early [within 14 d] or delayed)] and content (guideline adherent or nonadherent). LBP-related health care costs and utilization in the 18-months following primary care consultation were examined. Results. Physical therapy utilization was 7.0% with significant geographic variability. Early physical therapy timing was associated with decreased risk of advanced imaging (odds ratio [OR] = 0.34, 95% confidence interval [CI]: 0.29, 0.41), additional physician visits (OR = 0.26, 95% CI: 0.21, 0.32), surgery (OR = 0.45, 95% CI: 0.32, 0.64), injections (OR = 0.42, 95% CI: 0.32, 0.64), and opioid medications (OR = 0.78, 95% CI: 0.66, 0.93) compared with delayed physical therapy. Total medical costs for LBP were $2736.23 lower (95% CI: 1810.67, 3661.78) for patients receiving early physical therapy. Physical therapy content showed weaker associations with subsequent care. Conclusion. Early physical therapy following a new primary care consultation was associated with reduced risk of subsequent health care compared with delayed physical therapy. Further research is needed to clarify exactly which patients with LBP should be referred to physical therapy; however, if referral is to be made, delaying the initiation of physical therapy may increase risk for additional health care consumption and costs. C1 [Fritz, Julie M.] Univ Utah, Dept Phys Therapy, Intermt Healthcare, Salt Lake City, UT 84108 USA. [Childs, John D.] Baylor Univ, USA, Dept Phys Therapy, Ft Sam Houston, TX USA. [Wainner, Robert S.] Texas State Univ San Marcos, Dept Phys Therapy, San Marcos, TX USA. [Flynn, Timothy W.] Rocky Mt Univ Hlth Profess, Dept Phys Therapy, S Provo, UT USA. RP Fritz, JM (reprint author), Univ Utah, Dept Phys Therapy, Intermt Healthcare, 520 Wakara Way, Salt Lake City, UT 84108 USA. EM julie.fritz@hsc.utah.edu FU Orthopedic and Private Practice Sections of the American Physical Therapy Association; American Academy of Orthopaedic and Manual Physical Therapists; Texas State University FX The authors wish to acknowledge Mercer Health and Benefits, LLC for their assistance with data acquisition and analysis for this project. This project was supported financially by grants from the Orthopedic and Private Practice Sections of the American Physical Therapy Association and the American Academy of Orthopaedic and Manual Physical Therapists. Funds were also provided by a faculty grant from Texas State University. NR 46 TC 37 Z9 37 U1 0 U2 26 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0362-2436 EI 1528-1159 J9 SPINE JI SPINE PD DEC 1 PY 2012 VL 37 IS 25 BP 2114 EP 2121 DI 10.1097/BRS.0b013e31825d32f5 PG 8 WC Clinical Neurology; Orthopedics SC Neurosciences & Neurology; Orthopedics GA 047MI UT WOS:000311844600017 PM 22614792 ER PT J AU Stojadinovic, A Nissan, A Wainberg, Z Shen, P McCarter, M Protic, M Howard, RS Steele, SR Peoples, GE Bilchik, A AF Stojadinovic, Alexander Nissan, Aviram Wainberg, Zev Shen, Perry McCarter, Martin Protic, Mladjan Howard, Robin S. Steele, Scott R. Peoples, George E. Bilchik, Anton TI Time-Dependent Trends in Lymph Node Yield and Impact on Adjuvant Therapy Decisions in Colon Cancer Surgery: An International Multi-Institutional Study SO ANNALS OF SURGICAL ONCOLOGY LA English DT Article; Proceedings Paper CT Annual Meeting of the Pacific-Coast-Surgical-Association CY 2012 CL Napa, CA SP Pacific Coast Surg Assoc ID SURVIVAL; TRIAL; RESECTION; RATES AB Lymph node yield (LNY) and accuracy of nodal assessment are critical to staging and treatment planning in colon cancer (CC). A nationally agreed upon 12-node minimum is a quality standard in CC. The impact of this quality measure on LNY and impact on therapeutic decisions are evaluated in two international, multi-center, prospective trials comprising a well-characterized cohort assembled over 8 years (2001-2009) with long-term follow-up. Quality adherence through increased LNY improves staging accuracy and impacts adjuvant therapy decisions. Retrospective analysis of prospective data to assess time-dependent LNY, the dependent variable in multivariate linear regression analysis adjusted for age, gender, body-mass-index (BMI), tumor size/stage/grade, anatomic location and surgery date. Two-hundred-forty-five patients with non-metastatic CC, median age 70 years, BMI 26 kg/m(2), tumor size 4.0 cm, and LNY 17 nodes were studied. Seventy-two percent had T3 (70 %)/T4 (2 %) tumors. Adherence to the 12-node minimum was 70 %(2001-2002), 81 % (2003-2004), 90 % (2005-2006), 94 % (2007-2008). LNY significantly increased over time (Median LNY: 2001-2004 = 15 vs. 2005-2008 = 17; P < 0.001) on multivariate analysis controlling for tumor size (P < 0.001), and right-sided tumor location (P < 0.001). Adjuvant therapy administration and indication for chemotherapy according to LNY (< 12 vs. 12 + LNs = 33 % vs. 39 %; P = 0.48) and time period (2001-2004 vs. 2005-2008 = 39 % vs. 37 %; P = 0.89) remained unchanged. Despite the independent predictors of nodal yield (tumor location and size), year of study still had a significant impact on nodal yield. Despite increased quality adherence and LNY over time, there appears to be a delayed impact on adjuvant therapy decisions once quality standard adherence takes effect. C1 [Stojadinovic, Alexander] Walter Reed Army Med Ctr, Dept Surg, Washington, DC 20307 USA. [Stojadinovic, Alexander; Nissan, Aviram; Protic, Mladjan; Peoples, George E.; Bilchik, Anton] US Mil Canc Inst, Washington, DC USA. [Stojadinovic, Alexander; Peoples, George E.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [Nissan, Aviram] Beilinson Med Ctr, Rabin Med Ctr, Dept Surg B, Petah Tiqwa, Israel. [Wainberg, Zev; Bilchik, Anton] Univ Calif Los Angeles, David Geffen Sch Med, Calif Oncol Res Inst, Los Angeles, CA 90095 USA. [Shen, Perry] Wake Forest Baptist Med Ctr, Winston Salem, NC USA. [McCarter, Martin] Univ Colorado Denver, Dept Surg, Aurora, CO USA. [Protic, Mladjan] Clin Ctr Vojvodina, Clin Abdominal Endocrine & Transplantat Surg, Novi Sad, Serbia. [Howard, Robin S.] Walter Reed Army Med Ctr, Dept Clin Invest, Biostat Sect, Washington, DC 20307 USA. [Steele, Scott R.] Madigan Army Med Ctr, Dept Surg, Tacoma, WA 98431 USA. [Peoples, George E.] Brooke Army Med Ctr, San Antonio, TX USA. [Protic, Mladjan] Univ Novi Sad, Fac Med, Novi Sad 21000, Serbia. RP Stojadinovic, A (reprint author), Walter Reed Army Med Ctr, Dept Surg, Washington, DC 20307 USA. EM alexander.stojadinovic@med.navy.mil FU NCI NIH HHS [2R01CA090848-05A2] NR 21 TC 6 Z9 6 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1068-9265 J9 ANN SURG ONCOL JI Ann. Surg. Oncol. PD DEC PY 2012 VL 19 IS 13 BP 4178 EP 4185 DI 10.1245/s10434-012-2501-5 PG 8 WC Oncology; Surgery SC Oncology; Surgery GA 042ZT UT WOS:000311512400026 PM 22805869 ER PT J AU Zhelev, DV Hunt, M Le, A Dupuis, C Ren, S Gibbons, HS AF Zhelev, Doncho V. Hunt, Mia Le, Anna Dupuis, Christopher Ren, Suelynn Gibbons, Henry S. TI Effect of the Bacillus atrophaeus subsp globigii Spo0F H101R Mutation on Strain Fitness SO APPLIED AND ENVIRONMENTAL MICROBIOLOGY LA English DT Article ID REAL-TIME PCR; ESCHERICHIA-COLI; GENE-EXPRESSION; SPORULATION INITIATION; EXPERIMENTAL EVOLUTION; RPOS MUTATIONS; SUBTILIS; POPULATIONS; RESISTANCE; SELECTION AB Sporulation is a critical developmental process in Bacillus spp. that, once initiated, removes the possibility of further growth until germination. Therefore, the threshold conditions triggering sporulation are likely to be subject to evolutionary constraint. Our previous studies revealed two spontaneous hypersporulating mutants of Bacillus atrophaeus subsp. globigii, both containing point mutations in the spo0F gene. One of these strains (Detrick-2; contains the spo0F101 allele with a C:T [His101Arg] substitution) had been deliberately selected in the early 1940s as an anthrax surrogate. To determine whether the experimental conditions used during the selection of the "military" strains could have supported the emergence of hypersporulating variants, the relative fitness of strain Detrick-2 was measured in several experimental settings modeled on experimental conditions employed during its development in the 1940s as a simulant. The congenic strain Detrick-1 contained a wild-type spo0F gene and sporulated like the wild-type strain. The relative fitness of Detrick-1 and Detrick-2 was evaluated in competition experiments using quantitative single nucleotide polymorphism (SNP)-specific real-time PCR assays directed at the C:T substitution. The ancestral strain Detrick-1 had a fitness advantage under all conditions tested except when competing cultures were subjected to frequent heat shocks. The hypersporulating strain gained the maximum fitness advantage when cultures were grown at low oxygen tension and when heat shock was applied soon after the formation of the first heat-resistant spores. This is interpreted as gain of fitness by the hypersporulating strain in fast-changing fluctuating environments as a result of the increased rate of switching to the sporulating phenotype. C1 [Zhelev, Doncho V.; Hunt, Mia; Le, Anna; Dupuis, Christopher; Ren, Suelynn] USA, Sensors & Elect Devices Directorate, Res Lab, Adelphi, MD USA. [Gibbons, Henry S.] Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD USA. RP Zhelev, DV (reprint author), USA, Sensors & Elect Devices Directorate, Res Lab, Adelphi, MD USA. EM dontcho.jelev@us.army.mil FU Army Educational Outreach Program; Defense Threat Reduction Agency [CB2847, CB3238]; [W15P7T-06D-E402/DO118]; [W911NF-71-C0097] FX D.V.Z. acknowledges support from contract no. W15P7T-06D-E402/DO118, M.H. and A.L. were supported via contract no. W911NF-71-C0097, and C.D. and S.R. were supported by the Army Educational Outreach Program. H.S.G. is supported by the Defense Threat Reduction Agency under projects CB2847 and CB3238. NR 60 TC 0 Z9 0 U1 1 U2 8 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0099-2240 J9 APPL ENVIRON MICROB JI Appl. Environ. Microbiol. PD DEC PY 2012 VL 78 IS 24 BP 8601 EP 8610 DI 10.1128/AEM.01922-12 PG 10 WC Biotechnology & Applied Microbiology; Microbiology SC Biotechnology & Applied Microbiology; Microbiology GA 038ZS UT WOS:000311213200013 PM 23042165 ER PT J AU Mondello, S Gabrielli, A Catani, S D'Ippolito, M Jeromin, A Ciaramella, A Bossu, P Schmid, K Tortella, F Wang, KKW Hayes, RL Formisano, R AF Mondello, Stefania Gabrielli, Andrea Catani, Sheila D'Ippolito, Mariagrazia Jeromin, Andreas Ciaramella, Antonio Bossu, Paola Schmid, Kara Tortella, Frank Wang, Kevin K. W. Hayes, Ronald L. Formisano, Rita TI Increased levels of serum MAP-2 at 6-months correlate with improved outcome in survivors of severe traumatic brain injury SO BRAIN INJURY LA English DT Article DE MAP2; traumatic brain injury; biomarkers; outcome; cognitive functioning ID MICROTUBULE-ASSOCIATED PROTEIN-2; VEGETATIVE STATE; DENDRITIC SPINES; BARRIER FUNCTION; CONSCIOUSNESS; DISORDERS; MARKER; MEMORY; ACTIN; SCALE AB Objective: To evaluate microtubule-associated proteins (MAP-2), a dendritic marker of both acute damage and chronic neuronal regeneration after injury, in serum of survivors after severe TBI and examine the association with long-term outcome. Methods: Serum concentrations of MAP-2 were evaluated in 16 patients with severe TBI (Glasgow Coma Scale score [GCS] <= 8) 6 months post-injury and in 16 controls. Physical and cognitive outcomes were assessed, using the Glasgow Outcome Scale Extended (GOSE) and Levels of Cognitive Functioning Scale (LCFS), respectively. Results: Severe TBI patients had significantly higher serum MAP-2 concentrations than normal controls with no history of TBI (p = 0.008) at 6 months post-injury. MAP-2 levels correlated with the GOSE (r = 0.58, p = 0.02) and LCFS (r = 0.65, p = 0.007) at month 6. Significantly lower serum levels of MAP-2 were observed in patients in a vegetative state (VS) compared to non-VS patients (p < 0.05). A trend tracking the level of consciousness was observed. Conclusions: Severe TBI results in a chronic release of MAP-2 into the peripheral circulation in patients with higher levels of consciousness, suggesting that remodelling of synaptic junctions and neuroplasticity processes occur several months after injury. The data indicate MAP-2 as a potential marker for emergence to higher levels of cognitive function. C1 [Mondello, Stefania; Jeromin, Andreas; Wang, Kevin K. W.; Hayes, Ronald L.] Univ Florida, Dept Anesthesiol, Gainesville, FL USA. [Mondello, Stefania; Gabrielli, Andrea; Wang, Kevin K. W.; Hayes, Ronald L.] Banyan Biomarkers Inc, Clin Dept, Banyan Labs, Alachua, FL 32615 USA. [Catani, Sheila; D'Ippolito, Mariagrazia; Ciaramella, Antonio; Bossu, Paola; Formisano, Rita] Santa Lucia Fdn, Rome, Italy. [Schmid, Kara; Tortella, Frank] Walter Reed Army Inst Res, Silver Spring, MD USA. RP Mondello, S (reprint author), Banyan Biomarkers Inc, Dept Clin Programs, 13400 Progress Blvd, Alachua, FL 32615 USA. EM stm_mondello@hotmail.com RI Mondello, Stefania/A-1813-2012; Bosso, Paola/E-4832-2014; D'Ippolito, Mariagrazia/K-4010-2016; Ciaramella, Antonio/F-1170-2011; OI Mondello, Stefania/0000-0002-8587-3614; Bosso, Paola/0000-0002-1432-0078; D'Ippolito, Mariagrazia/0000-0001-7818-7352; Wang, Kevin/0000-0002-9343-6473; Ciaramella, Antonio/0000-0001-9888-8156; NACMIAS, Benedetta/0000-0001-9338-9040 FU Banyan Biomarkers Inc.; Department of Defense [DAMD17-03-1-0772, DAMD17-03-1-0066]; NIH [R01 NS049175-01, R01-NS052831-01, R01 NS051431-01]; Navy [N00014-06-1-1029]; Italian Ministry of Health [RF2008, n.31] FX Dr Mondello is a consultant of Banyan Biomarkers, Inc.; Dr Jeromin is an employee of Banyan Biomarkers; Dr Wang and Dr Hayes own stock, receive royalties and salaries from, and are officers of Banyan Biomarkers Inc. Drs Gabrielli, Tortella, Schmid, Catani, D'Ippolito, Ciaramella, Bossu and Formisano report no conflicts of interest.; This study was primarily sponsored by Department of Defense Award numbers DAMD17-03-1-0772 and DAMD17-03-1-0066; but we also acknowledge additional fund support from NIH (R01 NS049175-01, R01-NS052831-01 and R01 NS051431-01) and Navy grant number N00014-06-1-1029 (University of Florida). The collection of data in Santa Lucia Foundation was partially supported by the Italian Ministry of Health (grant RF2008, n.31). NR 34 TC 18 Z9 20 U1 3 U2 10 PU INFORMA HEALTHCARE PI LONDON PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND SN 0269-9052 J9 BRAIN INJURY JI Brain Inj. PD DEC PY 2012 VL 26 IS 13-14 BP 1629 EP 1635 DI 10.3109/02699052.2012.700083 PG 7 WC Neurosciences; Rehabilitation SC Neurosciences & Neurology; Rehabilitation GA 041RU UT WOS:000311419700009 PM 22794497 ER PT J AU Zhang, HC Zhang, YN Nasrabadi, NM Huang, TS AF Zhang, Haichao Zhang, Yanning Nasrabadi, Nasser M. Huang, Thomas S. TI Joint-Structured-Sparsity-Based Classification for Multiple-Measurement Transient Acoustic Signals SO IEEE TRANSACTIONS ON SYSTEMS MAN AND CYBERNETICS PART B-CYBERNETICS LA English DT Article DE Joint sparse representation; joint structured sparsity; multiple-measurement transient acoustic signal classification ID RECOVERY; RECONSTRUCTION; REPRESENTATION; SELECTION; RECOGNITION; PERSPECTIVE; VECTORS; PURSUIT AB This paper investigates the joint-structured-sparsity-based methods for transient acoustic signal classification with multiple measurements. By joint structured sparsity, we not only use the sparsity prior for each measurement but we also exploit the structural information across the sparse representation vectors of multiple measurements. Several different sparse prior models are investigated in this paper to exploit the correlations among the multiple measurements with the notion of the joint structured sparsity for improving the classification accuracy. Specifically, we propose models with the joint structured sparsity under different assumptions: same sparse code model, common sparse pattern model, and a newly proposed joint dynamic sparse model. For the joint dynamic sparse model, we also develop an efficient greedy algorithm to solve it. Extensive experiments are carried out on real acoustic data sets, and the results are compared with the conventional discriminative classifiers in order to verify the effectiveness of the proposed method. C1 [Zhang, Haichao; Zhang, Yanning] NW Polytech Univ, Sch Comp Sci, Xian 710129, Peoples R China. [Nasrabadi, Nasser M.] USA, Res Lab, Adelphi, MD 20783 USA. [Huang, Thomas S.] Univ Illinois, Beckman Inst, Urbana, IL 61801 USA. RP Zhang, HC (reprint author), NW Polytech Univ, Sch Comp Sci, Xian 710129, Peoples R China. EM hczhang@mail.nwpu.edu.cn; ynzhang@nwpu.edu.cn FU National Natural Science Foundation of China [60872145, 60903126]; National High Technology Research and Development Program (863) of China [2009AA01Z315]; China Postdoctoral (Special) Science Foundation [20090451397, 201003685]; Cultivation Fund of the Key Scientific and Technical Innovation Project from the Ministry of Education of China [708085]; U.S. Army Research Laboratory; U.S. Army Research Office [W911NF-09-1-0383] FX This work was supported in part by the National Natural Science Foundation of China under Grant 60872145 and Grant 60903126, by the National High Technology Research and Development Program (863) of China under Grant 2009AA01Z315, by the China Postdoctoral (Special) Science Foundation under Grant 20090451397 and Grant 201003685, by the Cultivation Fund of the Key Scientific and Technical Innovation Project from the Ministry of Education of China under Grant 708085, and by the U.S. Army Research Laboratory and U.S. Army Research Office under Grant W911NF-09-1-0383. This paper was recommended by Associate Editor N. Chawla. NR 52 TC 13 Z9 14 U1 2 U2 18 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1083-4419 J9 IEEE T SYST MAN CY B JI IEEE Trans. Syst. Man Cybern. Part B-Cybern. PD DEC PY 2012 VL 42 IS 6 BP 1586 EP 1598 DI 10.1109/TSMCB.2012.2196038 PG 13 WC Automation & Control Systems; Computer Science, Artificial Intelligence; Computer Science, Cybernetics SC Automation & Control Systems; Computer Science GA 040VS UT WOS:000311353700007 PM 22614692 ER PT J AU Bachynski, KE Canham-Chervak, M Black, SA Dada, EO Millikan, AM Jones, BH AF Bachynski, Kathleen E. Canham-Chervak, Michelle Black, Sandra A. Dada, Esther O. Millikan, Amy M. Jones, Bruce H. TI Mental health risk factors for suicides in the US Army, 2007-8 SO INJURY PREVENTION LA English DT Article ID POSTTRAUMATIC-STRESS-DISORDER; PRIMARY-CARE; MILITARY PERSONNEL; COMPLETED SUICIDE; MARITAL-STATUS; UNITED-STATES; REPRESENTATIVE SAMPLE; PSYCHOLOGICAL AUTOPSY; SUBSEQUENT TRAUMA; COMBAT EXPOSURE AB Objective Suicides among active duty US Army personnel have been increasing since 2004, surpassing comparable civilian rates in 2008. This analysis uses US military data to assess suicide rates for the 2-year period 2007-8, and examines relative risks (RR) of suicide associated with mental health disorders. Methods Historical trends of US Army suicides were assessed using 1977-2008 data from Army G-1 (Personnel). Suicide rates, RR and the 2000-8 trends of mental health disorders were calculated using data from the Defense Casualty Information Processing System and Defense Medical Surveillance System. Results A total of 255 soldiers committed suicide in 2007-8 (2008 rate 20.2 per 100 000). Factors associated with higher suicide risk included male gender, lower enlisted rank and mental health disorders treated on an outpatient basis (RR 3.9), as well as a number of mental health disorders (mood disorders, anxiety disorders, post-traumatic stress disorder, personality/psychotic disorders, substance-related disorders and adjustment disorder; RR range 4.7-24.5). Analysis of historical trends suggested that 25-50% of the suicides that occurred in 2008 might have been related to the major commitment of troops to combat beginning in 2003. Conclusions The recent increase in suicides parallels an increase in the prevalence of mental disorders across the army. This finding suggests that increasing rates of clinically treated psychopathology are associated with increasing rates of suicides; these rates probably serve as sentinels for suicide risk in this population. Soldiers seeking treatment for mental disorders and substance abuse should be a focus for suicide prevention. C1 [Canham-Chervak, Michelle] US Army Publ Hlth Command, Injury Prevent Program, ATTN MCHB IP DI, Aberdeen Proving Ground, MD 21010 USA. [Black, Sandra A.; Millikan, Amy M.] US Army Publ Hlth Command, Behav & Social Hlth Outcomes Program, Aberdeen Proving Ground, MD 21010 USA. RP Canham-Chervak, M (reprint author), US Army Publ Hlth Command, Injury Prevent Program, ATTN MCHB IP DI, Aberdeen Proving Ground, MD 21010 USA. EM chervak@us.army.mil FU US Army Public Health Command (USAPHC); US Department of Energy; USAPHC FX This work was supported in part by an appointment to the postgraduate research participation program at the US Army Public Health Command (USAPHC) administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the US Department of Energy and USAPHC. NR 85 TC 44 Z9 44 U1 3 U2 24 PU BMJ PUBLISHING GROUP PI LONDON PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND SN 1353-8047 J9 INJURY PREV JI Inj. Prev. PD DEC PY 2012 VL 18 IS 6 BP 405 EP 412 DI 10.1136/injuryprev-2011-040112 PG 8 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 041RC UT WOS:000311417900010 PM 22398362 ER PT J AU Boteler, L Jankowski, N McCluskey, P Morgan, B AF Boteler, Lauren Jankowski, Nicholas McCluskey, Patrick Morgan, Brian TI Numerical investigation and sensitivity analysis of manifold microchannel coolers SO INTERNATIONAL JOURNAL OF HEAT AND MASS TRANSFER LA English DT Article DE Manifold microchannel; Heat sink; Thermal resistance; Power packaging; Numerical ID HEAT SINK; TREE-LIKE AB This paper presents a numerical investigation of a single-phase manifold microchannel cooler (MMC) heat exchanger demonstrating a reduction in fluid pressure drop while improving chip-temperature uniformity. This modeling work includes the entire manifold length with multiple microchannels, whereas previous models have only focused on individual microchannels, ignoring complex manifold effects. Computational Fluid Dynamic (CFD) models were used to identify the impact of varying both the manifold and microchannel fin and channel dimensions, and a sensitivity analysis was performed with respect to system pressure drop, rise in device temperature, and thermal uniformity. This modeling work demonstrated both large velocity gradients between microchannels, as well as fluidic swirling in the microchannels that significantly improved the heat transfer coefficient. These results are absent from unit-cell type models. The results of the full MMC model showed significantly improved chip-temperature uniformity when large (approximately 10X) differences in velocity occurred between microchannels. The simulations also showed that, for equivalent thermal performance, the MMC design resulted in a 97% reduction in system pressure drop when compared to an equivalent straight microchannel cooler. Finally, the numerical pressure drop results were compared to a simpler, one-dimensional approximation based on the Hagen-Poiseuille equation. While under-predicting total pressure drop, the analytical equation does capture prevailing trends of the effects of channel dimensions on the pressure drop and can be used for rapid evaluation of numerous tradeoffs from a system perspective. Published by Elsevier Ltd. C1 [Boteler, Lauren; Jankowski, Nicholas; Morgan, Brian] USA, Res Lab, Adelphi, MD 20783 USA. [Boteler, Lauren; McCluskey, Patrick] Univ Maryland, College Pk, MD 20742 USA. RP Boteler, L (reprint author), USA, Res Lab, 2800 Powder Mill Rd,Bldg 207, Adelphi, MD 20783 USA. EM lauren.m.boteler.civ@mail.mil RI McCluskey, Patrick/H-6035-2013 NR 18 TC 11 Z9 11 U1 4 U2 22 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0017-9310 EI 1879-2189 J9 INT J HEAT MASS TRAN JI Int. J. Heat Mass Transf. PD DEC PY 2012 VL 55 IS 25-26 BP 7698 EP 7708 DI 10.1016/j.ijheatmasstransfer.2012.07.073 PG 11 WC Thermodynamics; Engineering, Mechanical; Mechanics SC Thermodynamics; Engineering; Mechanics GA 038TE UT WOS:000311196200033 ER PT J AU Bakas, M McCauley, JW Greenhut, V Niesz, D Haber, R West, B AF Bakas, Michael McCauley, James W. Greenhut, Victor Niesz, Dale Haber, Richard West, Bruce TI Quantitative analysis of inclusion distributions in hot pressed silicon carbide SO INTERNATIONAL JOURNAL OF IMPACT ENGINEERING LA English DT Article DE Silicon carbide; Defects; Distributions; Ballistic performance; Statistical analysis ID BRITTLE MATERIALS; DYNAMIC FAILURE; COMPRESSION; FRACTURE; DEFECTS; MODEL; CERAMICS; ROCK AB The main objective of this work was to investigate the relationship between microstructural defects and ballistic variability in hot pressed SiC. Two plates, 4 '' x 4 '' x 1 '' thick, from the same manufacturing lot, identified as samples A and B. were subjected to nominally identical high velocity impacts on the 4 '' x 4 '' face under which sample B performed more poorly than A. The exposed microstructural defects on fragments of the two samples were carefully characterized using scanning electron and optical microscopy. Two types of inclusion defects were identified: carbonaceous and aluminum-iron-oxide phases. While only small inclusions were found on polished cross sections, the rubble fracture surfaces were found to contain disproportionate numbers of large inclusions, strongly suggesting an influence on crack formation. A statistical function derived previously by Jayatilaka and Trustrum was successfully used to describe the defect populations. Sample A had more numerous, but smaller inclusions on its fragments than sample B. The exponent (n) of the distribution function can be related to the Weibull modulus (m) used to describe the strength variation of brittle materials by the relation m = 2n, a relationship that may be useful in efforts to represent defect distributions in micromechanical models. The data suggests that sample B has a higher probability of having a large inclusion on its fragments than sample A, which had more numerous smaller inclusions. Therefore, sample B would have a greater likelihood of crack nucleation and resulting failure at high strain rates from the distribution of large defects. The Pareto Principle, which suggests that 20% of the large inclusions in the tail of the distribution account for 80% of the total performance may be applicable. (C) 2012 Elsevier Ltd. All rights reserved. C1 [Bakas, Michael; Greenhut, Victor; Niesz, Dale; Haber, Richard] Rutgers State Univ, Dept Mat Sci & Engn, Piscataway, NJ 08854 USA. [McCauley, James W.] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. [West, Bruce] USA, Army Res Off, Res Lab, Res Triangle Pk, NC 27709 USA. EM Michael.Bakas@inl.gov FU Army Research Laboratory (ARMAC-RTP); ARMC-RTP [DAAD-19-01-2-0004] FX Much appreciation and thanks to George Quinn of NIST for his insight and aid in the course of this work. Thanks to Jeff Swab and Andrew Wereszczak for testing and providing the quasi-static samples examined in this study. Thanks to Ming Xie and Zhauyo Luo in the statistics department at Rutgers for their invaluable aid in calculating the distribution functions. This work was sponsored by the Army Research Laboratory (ARMAC-RTP) and was accomplished under the ARMC-RTP Cooperative Agreement Number DAAD-19-01-2-0004. The views and conclusions contained in this document are those of the authors and should not be interpreted as representing the official policies, either expressed or implied, of the Army Research Laboratory or the U.S. Government. The Government is authorized to reproduce and distribute reprints for Government purposes notwithstanding any copyright notation hereon. NR 37 TC 6 Z9 6 U1 1 U2 16 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0734-743X EI 1879-3509 J9 INT J IMPACT ENG JI Int. J. Impact Eng. PD DEC PY 2012 VL 50 BP 40 EP 48 DI 10.1016/j.ijimpeng.2012.06.010 PG 9 WC Engineering, Mechanical; Mechanics SC Engineering; Mechanics GA 043GI UT WOS:000311530500005 ER PT J AU Servinsky, MD Germane, KL Liu, S Kiel, JT Clark, AM Shankar, J Sund, CJ AF Servinsky, M. D. Germane, K. L. Liu, S. Kiel, J. T. Clark, A. M. Shankar, J. Sund, C. J. TI Arabinose is metabolized via a phosphoketolase pathway in Clostridium acetobutylicum ATCC 824 SO JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY LA English DT Article ID BUTANOL PRODUCTION; TRANSCRIPTIONAL ANALYSIS; GLUCOSE; NETWORK; XYLOSE; MODEL; PCR AB In this report, a novel zymogram assay and coupled phosphoketolase assay were employed to demonstrate that Clostridium acetobutylicum gene CAC1343 encodes a bi-functional xylulose-5-P/fructose-6-P phosphoketolase (XFP). The specific activity of purified recombinant XFP was 6.9 U/mg on xylulose-5-P and 21 U/mg on fructose-6-P, while the specific activity of XFP in concentrated C. acetobutylicum whole-cell extract was 0.094 and 0.52 U/mg, respectively. Analysis of crude cell extracts indicated that XFP activity was present in cells grown on arabinose but not glucose and quantitative PCR was used to show that CAC1343 mRNA expression was induced 185-fold during growth on arabinose when compared to growth on glucose. HPLC analysis of metabolites revealed that during growth on xylose and glucose more butyrate than acetate was formed with final acetate:butyrate ratios of 0.72 and 0.83, respectively. Growth on arabinose caused a metabolic shift to more oxidized products with a final acetate:butyrate ratio of 1.95. The shift towards more oxidized products is consistent with the presence of an XFP, suggesting that arabinose is metabolized via a phosphoketolase pathway while xylose is probably metabolized via the pentose phosphate pathway. C1 [Servinsky, M. D.; Germane, K. L.; Liu, S.; Kiel, J. T.; Clark, A. M.; Shankar, J.; Sund, C. J.] USA, Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA. RP Sund, CJ (reprint author), USA, Res Lab, Sensors & Electron Devices Directorate, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM christian.j.sund.civ@mail.mil RI sund, christian/G-3424-2013; OI SHANKAR, JATA/0000-0003-4993-9580 NR 27 TC 10 Z9 10 U1 1 U2 29 PU SPRINGER HEIDELBERG PI HEIDELBERG PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY SN 1367-5435 J9 J IND MICROBIOL BIOT JI J. Ind. Microbiol. Biotechnol. PD DEC PY 2012 VL 39 IS 12 BP 1859 EP 1867 DI 10.1007/s10295-012-1186-x PG 9 WC Biotechnology & Applied Microbiology SC Biotechnology & Applied Microbiology GA 038WW UT WOS:000311205800014 PM 22922942 ER PT J AU Hobbs, CV Voza, T De La Vega, P Vanvliet, J Conteh, S Penzak, SR Fay, MP Anders, N Ilmet, T Li, YH Borkowsky, W Krzych, U Duffy, PE Sinnis, P AF Hobbs, Charlotte V. Voza, Tatiana De La Vega, Patricia Vanvliet, Jillian Conteh, Solomon Penzak, Scott R. Fay, Michael P. Anders, Nicole Ilmet, Tiina Li, Yonghua Borkowsky, William Krzych, Urszula Duffy, Patrick E. Sinnis, Photini TI HIV Nonnucleoside Reverse Transcriptase Inhibitors and Trimethoprim-Sulfamethoxazole Inhibit Plasmodium Liver Stages SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article ID EXO-ERYTHROCYTIC STAGES; HUMAN HEPATOCYTE LINE; HUMAN HEPATIC CELLS; MALARIA PARASITES; FALCIPARUM; EFAVIRENZ; MICE; EXPRESSION; NEVIRAPINE; PHARMACOKINETICS AB Background. Although nonnucleoside reverse transcriptase inhibitors (NNRTIs) are usually part of first-line treatment regimens for human immunodeficiency virus (HIV), their activity on Plasmodium liver stages remains unexplored. Additionally, trimethoprim-sulfamethoxazole (TMP-SMX), used for opportunistic infection prophylaxis in HIV-exposed infants and HIV-infected patients, reduces clinical episodes of malaria; however, TMP-SMX effect on Plasmodium liver stages requires further study. Methods. We characterized NNRTI and TMP-SMX effects on Plasmodium liver stages in vivo using Plasmodium yoelii. On the basis of these results, we conducted in vitro studies assessing TMP-SMX effects on the rodent parasites P. yoelii and Plasmodium berghei and on the human malaria parasite Plasmodium falciparum. Results. Our data showed NNRTI treatment modestly reduced P. yoelii liver stage parasite burden and minimally extended prepatent period. TMP-SMX administration significantly reduced liver stage parasite burden, preventing development of patent parasitemia in vivo. TMP-SMX inhibited development of rodent and P. falciparum liver stage parasites in vitro. Conclusions. NNRTIs modestly affect liver stage Plasmodium parasites, whereas TMP-SMX prevents patent parasitemia. Because drugs that inhibit liver stages target parasites when they are present in lower numbers, these results may have implications for eradication efforts. Understanding HIV drug effects on Plasmodium liver stages will aid in optimizing treatment regimens for HIV-exposed and HIV-infected infected patients in malaria-endemic areas. C1 [Hobbs, Charlotte V.; Vanvliet, Jillian; Conteh, Solomon; Duffy, Patrick E.] NIAID, Lab Malaria Immunol & Vaccinol, NIH, Rockville, MD 20852 USA. [Voza, Tatiana] CUNY, Dept Biol Sci, New York City Coll Technol, Brooklyn, NY USA. [De La Vega, Patricia; Krzych, Urszula] Walter Reed Army Inst Res, Dept Cellular Immunol, Malaria Vaccine Branch, Silver Spring, MD USA. [Penzak, Scott R.] NIH, Ctr Clin, Dept Pharm, Clin Pharmacokinet Res Lab, Bethesda, MD 20892 USA. [Fay, Michael P.] NIAID, NIH, Biostat Res Branch, Rockville, MD 20852 USA. [Anders, Nicole] Johns Hopkins Sch Med, Dept Med, Div Clin Pharmacol, Baltimore, MD USA. [Hobbs, Charlotte V.; Li, Yonghua; Borkowsky, William] NYU, Dept Pediat, Div Infect Dis & Immunol, Sch Med, New York, NY 10016 USA. [Sinnis, Photini] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Mol Microbiol & Immunol, Baltimore, MD USA. [Voza, Tatiana; Sinnis, Photini] NYU, Dept Med Parasitol, New York, NY USA. RP Hobbs, CV (reprint author), NIAID, Lab Malaria Immunol & Vaccinol, NIH, 12735 Twinbrook Pkwy, Rockville, MD 20852 USA. EM charlotte.hobbs@nih.gov OI Fay, Michael P./0000-0002-8643-9625 FU New York University; NIH [R01 AI056840]; NIH Division of Intramural Research; US Army Medical Research and Materiel Command FX This work was funded by the New York University Global Public Health Research Challenge Fund (P. S. and C. H.), NIH R01 AI056840 (P. S.), the NIH Division of Intramural Research, and the US Army Medical Research and Materiel Command. NR 49 TC 9 Z9 9 U1 0 U2 3 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD DEC 1 PY 2012 VL 206 IS 11 BP 1706 EP 1714 DI 10.1093/infdis/jis602 PG 9 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 035SK UT WOS:000310968700012 PM 23125449 ER PT J AU Sliozberg, YR Sirk, TW Brennan, JK Andzelm, JW AF Sliozberg, Yelena R. Sirk, Timothy W. Brennan, John K. Andzelm, Jan W. TI Bead-spring models of entangled polymer melts: Comparison of hard-core and soft-core potentials SO JOURNAL OF POLYMER SCIENCE PART B-POLYMER PHYSICS LA English DT Article DE computer modeling; molecular dynamics; simulations ID DISSIPATIVE PARTICLE DYNAMICS; MOLECULAR-DYNAMICS; SIMULATIONS; SYSTEMS; LIQUIDS AB Two bead-spring models of flexible chains for generic coarse graining of entangled polymer melts, the excluded volume KremerGrest (KG) model and the modified segmental repulsive potential (mSRP) combined with a weakly repulsive potential, are compared. For chains containing an equivalent number of entanglements, we compare the chain characteristics of the KG and mSRP polymer models by determining the ratios of the entanglement lengths N-e(KG)/N-e(mSRP), the required total number of particles to capture comparable entanglement phenomena N-tot(KG)/N-tot(mSRP), and the time scaling ratios tmSRP/tKG. Our findings show that systems using the mSRP polymer model require half the number of particles and relax four times faster compared to the KG polymer model. (c) 2012 Wiley Periodicals, Inc. J Polym Sci Part B: Polym Phys, 2012 C1 [Sliozberg, Yelena R.; Sirk, Timothy W.; Brennan, John K.; Andzelm, Jan W.] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Sliozberg, YR (reprint author), USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. EM yelena.r.sliozberg.ctr@mail.mil FU U.S. Army Research Laboratory Enterprise for Multi-Scale Research of Materials; U.S. Army Research Laboratory (ARL) FX This work was funded by the U.S. Army Research Laboratory Enterprise for Multi-Scale Research of Materials. This research was supported in part by an appointment to the Postgraduate Research Participation Program at the U.S. Army Research Laboratory (ARL), administered by the Oak Ridge Institute of Science and Education through an interagency agreement between the U.S. Department of Energy and ARL. The authors are grateful to Joseph L. Lenhart, Jay Schieber, and Robert S. Hoy for productive discussions. The authors thank Martin Kroger for providing the Z1 software. NR 18 TC 5 Z9 5 U1 2 U2 26 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0887-6266 J9 J POLYM SCI POL PHYS JI J. Polym. Sci. Pt. B-Polym. Phys. PD DEC 1 PY 2012 VL 50 IS 24 BP 1694 EP 1698 DI 10.1002/polb.23175 PG 5 WC Polymer Science SC Polymer Science GA 037BG UT WOS:000311075400004 ER PT J AU Headley, S Germain, M Milch, C Pescatello, L Coughlin, MA Nindl, BC Cornelius, A Sullivan, S Gregory, S Wood, R AF Headley, Samuel Germain, Michael Milch, Charles Pescatello, Linda Coughlin, Mary Ann Nindl, Bradley C. Cornelius, Allen Sullivan, Sheila Gregory, Sara Wood, Richard TI Exercise Training Improves HR Responses and (V) over dotO(2peak) in Predialysis Kidney Patients SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Article DE CHRONIC KIDNEY DISEASE; AUTONOMIC NERVOUS SYSTEM; HR; HR RECOVERY ID GLOMERULAR-FILTRATION-RATE; CHRONIC-RENAL-FAILURE; SERUM CREATININE; DISEASE PATIENTS; PROGRESSION; INFLAMMATION; METAANALYSIS; EQUATION; MARKER; DIET AB HEADLEY, S., M. GERMAIN, C. MILCH, L. PESCATELLO, M. A. COUGHLIN, B. C. NINDL, A. CORNELIUS, S. SULLIVAN, S. GREGORY, and R. WOOD. Exercise Training Improves HR Responses and (V) over dotO(2peak) in Predialysis Kidney Patients. Med. Sci. Sports Exerc., Vol. 44, No. 12, pp. 2392-2399, 2012. Purpose: The current pilot and feasibility study was designed to examine the effect of 48 wk of moderate-intensity exercise training and dietary modification on kidney function and vascular parameters in chronic kidney disease (CKD) patients. Methods: Twenty-one stage 2-4 CKD patients (age, 18-70 yr) were randomly assigned to either the training group (TG, n = 10) or the usual care group (n = 11) for 48 wk. The TG received 48 wk of personal training (3 d.wk(-1) for up to 55 min per session at 50%-60% (V) over dotO(2peak)) and dietary counseling, whereas individuals in the usual care group received standard of care and were instructed not to start a structured exercise program while in the study. (V) over dotO(2peak), estimated glomerular filtration rate (eGFR), resting and ambulatory HR, plasma lipids (total cholesterol, LDL cholesterol, HDL cholesterol, and triglycerides), and inflammatory markers (high-sensitivity C-reactive protein and interleukin 6) were assessed at baseline and weeks 24 and 48. An independent group's t-test was used to compare glomerular filtration rate slopes between groups, whereas all other data were analyzed with ANCOVA using the baseline value as the covariate. Results: There were no statistically significant differences in any of the parameters at baseline. The 48-wk intervention led to a significant increase in (V) over dotO(2peak), reductions in both resting and ambulatory HR, and increases in LDL cholesterol and in TG, but it had no effect on the rate of change of eGFR over time. Conclusions: A 48-wk exercise training program, primarily focused on aerobic exercise, increases (V) over dotO(2peak) and favorably alters autonomic function as evidenced by reductions in HR in stages 2-4 CKD patients. The exercise intervention had no effect on kidney function as assessed by eGFR. C1 [Headley, Samuel] Springfield Coll, Exercise Sci & Sports Studies Dept, Springfield, MA 01109 USA. [Germain, Michael] Western New England Renal & Transplant Associates, Springfield, MA USA. [Pescatello, Linda] Univ Connecticut, Storrs, CT USA. [Nindl, Bradley C.] USA, Environm Med Res Inst, Natick, MA 01760 USA. [Cornelius, Allen] Univ Rockies, Colorado Springs, CO USA. [Sullivan, Sheila] Baystate Med Ctr, Springfield, MA USA. RP Headley, S (reprint author), Springfield Coll, Exercise Sci & Sports Studies Dept, 263 Alden St, Springfield, MA 01109 USA. EM Sheadley@springfieldcollege.edu FU Baystate Medical Center Incubator Fund; Graduate Research Fund at Springfield College FX This study was supported by grants from Baystate Medical Center Incubator Fund and from the Graduate Research Fund at Springfield College. NR 34 TC 12 Z9 13 U1 0 U2 11 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD DEC PY 2012 VL 44 IS 12 BP 2392 EP 2399 DI 10.1249/MSS.0b013e318268c70c PG 8 WC Sport Sciences SC Sport Sciences GA 040GQ UT WOS:000311310600017 PM 22811032 ER PT J AU Papi, PA Mulligan, CP Gall, D AF Papi, P. A. Mulligan, C. P. Gall, D. TI CrN-Ag nanocomposite coatings: Control of lubricant transport by diffusion barriers SO THIN SOLID FILMS LA English DT Article DE Diffusion barrier; Nanocomposites; Hard coatings; Solid lubrication; High temperature lubrication; Chromium nitride silver ID TRIBOLOGICAL COATINGS; COMPOSITE COATINGS; TEMPERATURE; SILVER; GROWTH; FILMS; MICROSTRUCTURE; FRICTION; BEHAVIOR AB 1-mu m-thick self-lubricating CrN-Ag composite coatings containing 16 at.% Ag were deposited on Si substrates by reactive co-sputtering at T-s=400 degrees C, and were covered with CrN cap layers with a columnar microstructure and a thickness d=0-1000 nm. Vacuum annealing at T-a=500 and 600 degrees C for 1 h causes Ag transport to the sample surface and the formation of Ag surface grains. Quantitative scanning electron microscopy and energy dispersive spectroscopy analyses show that increasing d from 0 to 10 to 100 nm for T-a=500 degrees C leads to a decrease in the areal density of Ag surface grains from 0.86 to 0.45 to 0.04 mu m(-2), while their lateral size remains constant at 360 +/- 60 nm. However, increasing T-a to 600 degrees C causes a doubling of the Ag grain size, and a 4-30 times larger overall Ag transport. These results are explained by kinetic barriers for Ag diffusion through the porous cap layer with a porosity that decreases with increasing d, resulting in an effective activation barrier for Ag transport that increases from 0.78 eV in the absence of a cap layer to 0.89 eV for d=10 nm and 1.07 eV for d=30 nm. Auger electron spectroscopy depth profile analyses of annealed layers reveal no detectable Ag within the CrN cap layer and a uniform depletion of the Ag reservoir throughout the composite coating thickness, indicating unhindered Ag transport within the composite. The overall results show that a CrN diffusion barrier cap layer is an effective approach to control Ag lubricant transport to the surface of CrN-Ag composite coatings. (C) 2012 Elsevier B. V. All rights reserved. C1 [Papi, P. A.; Mulligan, C. P.; Gall, D.] Rensselaer Polytech Inst, Dept Mat Sci & Engn, Troy, NY 12180 USA. [Mulligan, C. P.] USA, Armament Res Dev & Engn Ctr, Benet Labs, Watervliet, NY 12189 USA. RP Gall, D (reprint author), Rensselaer Polytech Inst, Dept Mat Sci & Engn, Troy, NY 12180 USA. EM galld@rpi.edu RI Gall, Daniel/B-1060-2008 OI Gall, Daniel/0000-0002-5762-9307 FU National Science Foundation [1031201] FX This research was supported by the National Science Foundation, under grant No. 1031201. The authors thank Prof. Thierry Blanchet of Rensselaer Polytechnic Institute for many valuable discussions during the preparation of this manuscript. NR 37 TC 6 Z9 7 U1 8 U2 35 PU ELSEVIER SCIENCE SA PI LAUSANNE PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND SN 0040-6090 J9 THIN SOLID FILMS JI Thin Solid Films PD DEC 1 PY 2012 VL 524 BP 211 EP 217 DI 10.1016/j.tsf.2012.10.010 PG 7 WC Materials Science, Multidisciplinary; Materials Science, Coatings & Films; Physics, Applied; Physics, Condensed Matter SC Materials Science; Physics GA 041OE UT WOS:000311410300034 ER PT J AU Buckley, P Rivers, B Katoski, S Kim, MH Kragl, FJ Broomall, S Krepps, M Skowronski, EW Rosenzweig, CN Paikoff, S Emanuel, P Gibbons, HS AF Buckley, Patricia Rivers, Bryan Katoski, Sarah Kim, Michael H. Kragl, F. Joseph Broomall, Stacey Krepps, Michael Skowronski, Evan W. Rosenzweig, C. Nicole Paikoff, Sari Emanuel, Peter Gibbons, Henry S. TI Genetic Barcodes for Improved Environmental Tracking of an Anthrax Simulant SO APPLIED AND ENVIRONMENTAL MICROBIOLOGY LA English DT Article ID THURINGIENSIS SUBSP KURSTAKI; COMPLETE GENOME SEQUENCE; BACILLUS-THURINGIENSIS; INHALATIONAL ANTHRAX; UNITED-STATES; CEREUS; VIRULENCE; PLASMIDS; STRAINS; PXO1 AB The development of realistic risk models that predict the dissemination, dispersion and persistence of potential biothreat agents have utilized nonpathogenic surrogate organisms such as Bacillus atrophaeus subsp. globigii or commercial products such as Bacillus thuringiensis subsp. kurstaki. Comparison of results from outdoor tests under different conditions requires the use of genetically identical strains; however, the requirement for isogenic strains limits the ability to compare other desirable properties, such as the behavior in the environment of the same strain prepared using different methods. Finally, current methods do not allow long-term studies of persistence or reaerosolization in test sites where simulants are heavily used or in areas where B. thuringiensis subsp. kurstaki is applied as a biopesticide. To create a set of genetically heterogeneous yet phenotypically indistinguishable strains so that variables intrinsic to simulations (e.g., sample preparation) can be varied and the strains can be tested under otherwise identical conditions, we have developed a strategy of introducing small genetic signatures ("barcodes") into neutral regions of the genome. The barcodes are stable over 300 generations and do not impact in vitro growth or sporulation. Each barcode contains common and specific tags that allow differentiation of marked strains from wild-type strains and from each other. Each tag is paired with specific real-time PCR assays that facilitate discrimination of barcoded strains from wild-type strains and from each other. These uniquely barcoded strains will be valuable tools for research into the environmental fate of released organisms by providing specific artificial detection signatures. C1 [Buckley, Patricia; Rivers, Bryan; Katoski, Sarah; Kim, Michael H.; Kragl, F. Joseph; Broomall, Stacey; Krepps, Michael; Skowronski, Evan W.; Rosenzweig, C. Nicole; Emanuel, Peter; Gibbons, Henry S.] USA, Biosci Div, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD USA. [Rivers, Bryan; Katoski, Sarah] Sci Applicat Int Corp, Aberdeen Proving Ground, MD USA. [Krepps, Michael] Excet Inc, Aberdeen Proving Ground, MD USA. [Paikoff, Sari] Def Threat Reduct Agcy, Ft Belvoir, VA USA. RP Gibbons, HS (reprint author), USA, Biosci Div, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD USA. EM henry.s.gibbons.civ@mail.mil FU Defense Threat Reduction Agency (DTRA) [CB3654, CB2847] FX This work was supported by the Defense Threat Reduction Agency (DTRA) project number CB3654 to H. S. G. Sequencing of the B. thuringiensis subsp. kurstaki isolate was supported by DTRA project number CB2847 to H. S. G., C.N.R, and E.W.S. NR 48 TC 7 Z9 7 U1 2 U2 16 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0099-2240 J9 APPL ENVIRON MICROB JI Appl. Environ. Microbiol. PD DEC PY 2012 VL 78 IS 23 BP 8272 EP 8280 DI 10.1128/AEM.01827-12 PG 9 WC Biotechnology & Applied Microbiology; Microbiology SC Biotechnology & Applied Microbiology; Microbiology GA 035AY UT WOS:000310915300013 PM 23001658 ER PT J AU Muinonen, K Mishchenko, MI Dlugach, JM Zubko, E Penttila, A Videen, G AF Muinonen, K. Mishchenko, M. I. Dlugach, J. M. Zubko, E. Penttila, A. Videen, G. TI COHERENT BACKSCATTERING VERIFIED NUMERICALLY FOR A FINITE VOLUME OF SPHERICAL PARTICLES SO ASTROPHYSICAL JOURNAL LA English DT Article DE minor planets, asteroids: general; planets and satellites: surfaces; polarization radiative transfer; scattering ID MULTIPLE-SCATTERING; RADIATIVE-TRANSFER; LIGHT-SCATTERING; T-MATRIX; INTERFACE; OBJECT; SYSTEM; SPHERES; MEDIA AB We consider electromagnetic scattering by a spherical volume sparsely and randomly populated by spherical particles of equal size and optical properties. The far-field scattering matrix of the entire volume is computed using an exact method and an approximate method. The former is a direct computer solver of the Maxwell equations called the superposition T-matrix method (STMM). The latter is a solver based on numerical Monte Carlo integration of the ladder and cyclical diagrams appearing in the microphysical theory of radiative transfer and coherent backscattering (RT-CB). The quantitative agreement between the STMM and RT-CB computations provides verification of the RT-CB theory. Prominent backscattering features exhibited by the STMM data cannot be reproduced by keeping only the ladder diagrams of RT. Our results strongly support the CB explanation of opposition brightness and polarization phenomena observed for a class of atmosphereless solar-system objects. Further research is necessary to determine the range of quantitative applicability of the RT-CB theory to densely packed particulate media. C1 [Muinonen, K.; Zubko, E.; Penttila, A.] Univ Helsinki, Dept Phys, FI-00014 U Helsinki, Finland. [Mishchenko, M. I.] NASA Goddard Inst Space Studies, New York, NY 10025 USA. [Dlugach, J. M.] Natl Acad Sci Ukraine, Main Astron Observ, UA-03680 Kiev, Ukraine. [Videen, G.] Army Res Lab, Adelphi, MD 20783 USA. [Muinonen, K.] Finnish Geodet Inst, FI-02431 Masala, Finland. [Zubko, E.] Kharkov Natl Univ, Inst Astron, UA-61022 Kharkov, Ukraine. RP Muinonen, K (reprint author), Univ Helsinki, Dept Phys, Gustaf Hallstromin Katu 2A, FI-00014 U Helsinki, Finland. EM karri.muinonen@helsinki.fi; michael.i.mishchenko@nasa.gov; dl@mao.kiev.ua; evgenij.zubko@helsinki.fi; antti.i.penttila@helsinki.fi; gorden.videen@gmail.com RI Penttila, Antti/C-4886-2012; Mishchenko, Michael/D-4426-2012 OI Penttila, Antti/0000-0001-7403-1721; FU Academy of Finland [127461]; NASA Outer Planets Research Program [NNX10AP93G]; NASA Lunar Advanced Science and Exploration Research Program [NNX11AB25G]; NASA Radiation Sciences Program; NASA Remote Sensing Theory Program; National Academy of Sciences of Ukraine under the Main Astronomical Observatory GRAPE/GPU/GRID Computing Cluster Project FX This research has been partially funded by the Academy of Finland (contract 127461), NASA Outer Planets Research Program (contract NNX10AP93G), and NASA Lunar Advanced Science and Exploration Research Program (contract NNX11AB25G), as well as by the NASA Radiation Sciences Program managed by Hal Maring and by the NASA Remote Sensing Theory Program managed by Lucia Tsaoussi. M.I.M. and J.M.D. also acknowledge support from the National Academy of Sciences of Ukraine under the Main Astronomical Observatory GRAPE/GPU/GRID Computing Cluster Project. NR 42 TC 34 Z9 35 U1 0 U2 7 PU IOP PUBLISHING LTD PI BRISTOL PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND SN 0004-637X J9 ASTROPHYS J JI Astrophys. J. PD DEC 1 PY 2012 VL 760 IS 2 AR 118 DI 10.1088/0004-637X/760/2/118 PG 11 WC Astronomy & Astrophysics SC Astronomy & Astrophysics GA 039BE UT WOS:000311217000022 ER PT J AU Cheuvront, SN Ely, BR Kenefick, RW Buller, MJ Charkoudian, N Sawka, MN AF Cheuvront, Samuel N. Ely, Brett R. Kenefick, Robert W. Buller, Mark J. Charkoudian, Nisha Sawka, Michael N. TI Hydration assessment using the cardiovascular response to standing SO EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY LA English DT Article DE Dehydration; Hypohydration; Hypovolemia; Volume depletion; Orthostatic test; Diuretic; Heart rate ID CARDIAC BAROREFLEX SENSITIVITY; ORTHOSTATIC VITAL SIGNS; BIOLOGICAL VARIATION; HEAT-STRESS; TILT TEST; DEHYDRATION; BLOOD; HUMANS; HEALTHY; PLASMA AB The cardiovascular response to standing (sit-to-stand change in heart rate; SS Delta HR) is commonly employed as a screening tool to detect hypohydration (body water deficit). No study has systematically evaluated SS Delta HR cut points using different magnitudes or different types of controlled hypohydration. The objective of this study was to determine the diagnostic accuracy of the often proposed 20 b/min SS Delta HR cut point using both hypertonic and isotonic models of hypohydration. Thirteen healthy young adults (8M, 5F) underwent three bouts of controlled hypohydration. The first bout used sweating to elicit large losses of body water (mass) (> 3 % sweat). The second two bouts were matched to elicit 3 % body mass losses (3 % diuretic; 3 % sweat). A euhydration control trial (EUH) was paired with each hypohydration trial for a total of six trials. Heart rate was assessed after 3-min sitting and after 1-min standing during all trials. SS Delta HR was compared among trials, and receiver operator characteristic curve analysis was used to determine diagnostic accuracy of the 20 b/min SS Delta HR cut point. Volunteers lost 4.5 +/- A 1.1, 3.0 +/- A 0.6, and 3.2 +/- A 0.6 % body mass during > 3 % sweat, 3 % diuretic, and 3 % sweat trials, respectively. SS Delta HR (b/min) was 9 +/- A 8 (EUH), 20 +/- A 12 (> 3 % sweat; P < 0.05 vs. EUH), 17 +/- A 7 (3 % diuretic; P < 0.05 vs. EUH), and 13 +/- A 11 (3 % sweat). The 20 beats/min cut point had high specificity (90 %) but low sensitivity (44 %) and overall diagnostic accuracy of 67 %. SS Delta HR increased significantly in response to severe hypertonic hypohydration and moderate isotonic hypohydration, but not moderate hypertonic hypohydration. However, the 20 beats/min cut point afforded only marginal diagnostic accuracy. C1 [Cheuvront, Samuel N.; Ely, Brett R.; Kenefick, Robert W.; Buller, Mark J.; Charkoudian, Nisha; Sawka, Michael N.] USA, Thermal & Mt Med Div, Environm Med Res Inst, Natick, MA 01760 USA. RP Cheuvront, SN (reprint author), USA, Thermal & Mt Med Div, Environm Med Res Inst, Kansas St, Natick, MA 01760 USA. EM Samuel.n.cheuvront@us.army.mil NR 47 TC 4 Z9 4 U1 0 U2 7 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1439-6319 J9 EUR J APPL PHYSIOL JI Eur. J. Appl. Physiol. PD DEC PY 2012 VL 112 IS 12 BP 4081 EP 4089 DI 10.1007/s00421-012-2390-0 PG 9 WC Physiology; Sport Sciences SC Physiology; Sport Sciences GA 035ZT UT WOS:000310994800015 PM 22481637 ER PT J AU Mungan, CE Rogers, SD Satyan, N White, JO AF Mungan, Carl E. Rogers, Steven D. Satyan, Naresh White, Jeffrey O. TI Time-Dependent Modeling of Brillouin Scattering in Optical Fibers Excited by a Chirped Diode Laser SO IEEE JOURNAL OF QUANTUM ELECTRONICS LA English DT Article DE Brillouin scattering; chirped lasers; fiber amplifiers; numerical simulation ID SUPPRESSION; AMPLIFIERS; STEADY AB Numerical simulations are used to solve the coupled partial differential equations describing stimulated Brillouin scattering (SBS) built up from random thermal phonons as a function of time and the longitudinal spatial coordinate in an optical fiber. In the case of a passive fiber, a laser beam is incident with constant power, but its frequency is linearly ramped at 1.55 mu m at a rate of up to 10(16) Hz/s. High chirp rates lead to an increased Brillouin spectral bandwidth and decreased gain. The resulting SBS suppression is well described by an adiabatic model and agrees with experimental results. For an 18-m active fiber pumped at 1.06 mu m and chirped at up to 2 x 10(16) Hz/s, the suppression enables output laser powers in the kilowatt range while maintaining a narrow instantaneous linewidth. C1 [Mungan, Carl E.] USN Acad, Dept Phys, Annapolis, MD 21402 USA. [Rogers, Steven D.; White, Jeffrey O.] USA, Res Lab, Adelphi, MD 20783 USA. [Satyan, Naresh] CALTECH, Dept Appl Phys & Mat Sci, Pasadena, CA 91125 USA. RP Mungan, CE (reprint author), USN Acad, Dept Phys, Annapolis, MD 21402 USA. EM mungan@usna.edu; rogers1@umbc.edu; naresh@caltech.edu; jeffrey.owen.white@us.arl.mil FU High Energy Laser Joint Technology Office [11-SA-0405] FX This work was supported in part by the High Energy Laser Joint Technology Office under Grant 11-SA-0405. NR 18 TC 5 Z9 6 U1 1 U2 19 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0018-9197 J9 IEEE J QUANTUM ELECT JI IEEE J. Quantum Electron. PD DEC PY 2012 VL 48 IS 12 BP 1542 EP 1546 DI 10.1109/JQE.2012.2225414 PG 5 WC Engineering, Electrical & Electronic; Optics; Physics, Applied SC Engineering; Optics; Physics GA 040VV UT WOS:000311354200003 ER PT J AU Yoon, KL Quartana, PJ AF Yoon, K. Lira Quartana, Phillip J. TI Post-Evaluative Biases Toward Somatic Stimuli and Cardiovascular Responses in Social Anxiety SO JOURNAL OF PSYCHOPATHOLOGY AND BEHAVIORAL ASSESSMENT LA English DT Article DE Social anxiety; Somatic; Cardiovascular reactivity; Attentional bias; Social stress ID SPEAKING TASK; ATTENTIONAL BIAS; INDIVIDUALS; PHOBIA; SUPPRESSION; APPRAISAL; EMOTION; STRESS; THREAT; MODEL AB Cognitive models of social anxiety emphasize the role of an attentional shift toward cues related to somatic state in social anxiety. We examined attentional biases to somatic cues and cardiovascular reactivity in response to a social evaluative task. Participants performed an impromptu speech during which they received standardized negative evaluative comments. Participants then completed a dot-probe task with social evaluative, somatic, and anger-related words. Blood pressure (BP) and heart rate (HR) were assessed in 1-minute intervals during baseline, the speech task, and the dot-probe task. Despite the fact that a high social anxiety group reported higher levels of anxiety, high and low social anxiety groups did not differ in their speech task-evoked BP or HR responses. Furthermore, the high social anxiety group, compared to the low social anxiety group, exhibited greater attentional biases to somatic words, suggesting greater attention directed toward information pertinent to somatic arousal. C1 [Yoon, K. Lira] Univ Maine, Dept Psychol, Orono, ME 04469 USA. [Quartana, Phillip J.] Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci, Silver Spring, MD USA. RP Yoon, KL (reprint author), Univ Maine, Dept Psychol, 301 Little Hall, Orono, ME 04469 USA. EM lira.k.yoon@umit.maine.edu NR 28 TC 1 Z9 1 U1 4 U2 15 PU SPRINGER/PLENUM PUBLISHERS PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0882-2689 J9 J PSYCHOPATHOL BEHAV JI J. Psychopathol. Behav. Assess. PD DEC PY 2012 VL 34 IS 4 BP 451 EP 457 DI 10.1007/s10862-012-9302-9 PG 7 WC Psychology, Clinical SC Psychology GA 035OU UT WOS:000310957600003 ER PT J AU Umphres, GD Roelke, DL Netherland, MD AF Umphres, George D. Roelke, Daniel L. Netherland, Michael D. TI A chemical approach for the mitigation of Prymnesium parvum blooms SO TOXICON LA English DT Article DE Prymnesium parvum; Flumioxazin; Aquatic herbicide; Algae control; Fisheries management ID CYANOBACTERIUM OSCILLATORIA-PERORNATA; OXIDASE-INHIBITING HERBICIDES; DIFFERENT NUTRIENT CONDITIONS; CLIMATE-CHANGE; ALGAL BLOOMS; POPULATION-DYNAMICS; TOXIC HAPTOPHYTE; GLOBAL CHANGE; BARLEY-STRAW; FISH AB Known as Golden Algae in popular media, the harmful algal bloom causing organism Prymnesium parvum secretes increased amounts of toxic chemicals called prymnesins when stressed, resulting in major fish kills in Texas. Although many options exist for mitigation of blooms, a feasible protocol for control of blooms on large-scale impoundments has yet to be identified. Chemical control of P. parvum using six different enzyme inhibiting aquatic herbicides was explored in laboratory experiments. Of the six chemicals screened, one (flumioxazin) was selected for further study due to a significant decrease in P. parvum cell numbers with increasing chemical concentration. It was applied to natural plankton communities during in-situ experiments (Lake Granbury, Texas). The first experiment was conducted during a period of P. parvum bloom initiation (March) and the second experiment conducted during a post bloom period (April). Experiments were carried out in 20 L polycarbonate carboys covered in 30% shade cloth to simulate natural light, temperature and turbulence conditions. Through cell counts via light-microscopy, the chemical flumioxazin was found to cause significant decreases in P. parvum, but no significant differences in zooplankton abundance during the period of bloom initiation. However, significant decreases in adult copepods were observed during the post bloom period, with no significant decreases in P. parvum most likely due to decreased light penetration and inhibition of the photosensitive mode of action. (C) 2012 Elsevier Ltd. All rights reserved. C1 [Umphres, George D.; Roelke, Daniel L.] Texas A&M Univ, Dept Wildlife & Fisheries Sci, College Stn, TX 77843 USA. [Netherland, Michael D.] USA, ERDC, Gainesville, FL 32653 USA. RP Roelke, DL (reprint author), Texas A&M Univ, Dept Wildlife & Fisheries Sci, 2258 TAMUS, College Stn, TX 77843 USA. EM droelke@tamu.edu RI Roelke, Daniel/B-5766-2008 FU U.S. Army Engineer Research and Development Center; Aquatic Nuisance Species Research Program; Texas Water Resources Institute FX This research was supported by a U.S. Army Engineer Research and Development Center, Aquatic Nuisance Species Research Program and a Texas Water Resources Institute grant. Permission to publish this information was granted by the Chief of Engineers. We thank George Gable and Natalie Hewitt for assistance with field and laboratory work. NR 72 TC 4 Z9 4 U1 5 U2 62 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0041-0101 J9 TOXICON JI Toxicon PD DEC 1 PY 2012 VL 60 IS 7 BP 1235 EP 1244 DI 10.1016/j.toxicon.2012.08.006 PG 10 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA 038LZ UT WOS:000311177500003 PM 22960102 ER PT J AU Schwarz, E Guest, PC Rahmoune, H Martins-de-Souza, D Niebuhr, DW Weber, NS Cowan, DN Yolken, RH Spain, M Barnes, A Bahn, S AF Schwarz, Emanuel Guest, Paul C. Rahmoune, Hassan Martins-de-Souza, Daniel Niebuhr, David W. Weber, Natalya S. Cowan, David N. Yolken, Robert H. Spain, Michael Barnes, Anthony Bahn, Sabine TI Identification of a blood-based biological signature in subjects with psychiatric disorders prior to clinical manifestation SO WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY LA English DT Article DE Psychiatric disorders; schizophrenia; bipolar disorder; biomarkers; multiplex immunoassay ID SCHIZOPHRENIA-PATIENTS; UNTREATED PSYCHOSIS; BIPOLAR DISORDER; APOLIPOPROTEIN-E; HEALTHY CONTROLS; INFLAMMATION; HYPOTHESIS; PEPTIDES; DURATION; MARKERS AB Objectives. To determine whether a molecular signature is present in blood of patients with psychiatric disorders before manifestation of symptoms. Methods. Multiplex immunoassay analyses were carried out using serum obtained from two case-control studies of schizophrenia (n = 75) and bipolar disorder (n = 110) patients and their matched controls. The samples were drawn within 1 month before estimated onset of illness. Results. This led to identification of 20 molecules which were altered in pre-schizophrenia and 14 molecules in pre-bipolar disorder subjects compared to controls. Only two of these molecular changes were identical in both data sets and predictive testing confirmed that the biomarker signatures for pre-schizophrenia and pre-bipolar disorder were dissimilar. Conclusion. The present results suggest that there are distinct serum alterations that occur before clinical manifestation of schizophrenia and bipolar disorder. These findings could lead to development of diagnostic tests to help clinical psychiatrists identify and classify vulnerable patients early in the disease process, allowing for earlier and more effective therapeutic intervention. C1 [Schwarz, Emanuel; Guest, Paul C.; Rahmoune, Hassan; Martins-de-Souza, Daniel; Bahn, Sabine] Univ Cambridge, Dept Chem Engn & Biotechnol, Cambridge CB2 1QT, England. [Niebuhr, David W.; Weber, Natalya S.; Cowan, David N.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Yolken, Robert H.] Stanley Med Res Inst, Chevy Chase, MD USA. [Spain, Michael; Barnes, Anthony] Rules Based Med Inc, Austin, TX USA. [Bahn, Sabine] Erasmus MC, Dept Neurosci, Rotterdam, Netherlands. RP Bahn, S (reprint author), Univ Cambridge, Dept Chem Engn & Biotechnol, Tennis Court Rd, Cambridge CB2 1QT, England. EM sb209@cam.ac.uk RI Martins-de-Souza, Daniel/E-7021-2010; OI Martins-de-Souza, Daniel/0000-0003-3595-5846; guest, paul/0000-0002-5030-7137 FU Stanley Medical Research Institute (SMRI); European Union FP7 SchizDX research programme [223427]; US Department of the Army FX This research was supported by the Stanley Medical Research Institute (SMRI), the European Union FP7 SchizDX research programme (grant reference 223427) and the US Department of the Army. The views expressed are those of the authors and should not be construed to represent the positions of the Department of the Army or Department of Defense. NR 34 TC 22 Z9 22 U1 0 U2 11 PU INFORMA HEALTHCARE PI LONDON PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND SN 1562-2975 J9 WORLD J BIOL PSYCHIA JI World J. Biol. Psychiatry PD DEC PY 2012 VL 13 IS 8 BP 627 EP 632 DI 10.3109/15622975.2011.599861 PG 6 WC Psychiatry SC Psychiatry GA 036ON UT WOS:000311037300009 PM 21936765 ER PT J AU Price, JA Rogers, JV Plahovinsak, JL Wendling, MQS Perry, MR Reid, FM Graham, JS AF Price, Jennifer A. Rogers, James V. Plahovinsak, Jennifer L. Wendling, Morgan Q. S. Perry, Mark R. Reid, Frances M. Graham, John S. TI Toxicogenomic analysis of chlorine vapor-induced porcine skin injury SO CUTANEOUS AND OCULAR TOXICOLOGY LA English DT Article DE Chlorine; skin; porcine; Microarray ID FIBROBLAST GROWTH-FACTORS; SULFUR MUSTARD; GENE-EXPRESSION; CHEMOKINE RECEPTORS; WEANLING SWINE; INFLAMMATORY DISORDERS; MICROARRAY ANALYSIS; IN-VIVO; BURNS; EPIDERMIS AB Chlorine is an industrial chemical that can cause cutaneous burns. Understanding the molecular mechanisms of tissue damage and wound healing is important for the selection and development of an effective post-exposure treatment. This study investigated the effect of cutaneous chlorine vapor exposure using a weanling swine burn model and microarray analysis. Ventral abdominal sites were exposed to a mean calculated chlorine vapor concentration of 2.9 g/L for 30 min. Skin samples were harvested at 1.5 h, 3 h, 6 h, and 24 h post-exposure and stored in RNAlater(R) until processing. Total RNA was isolated, processed, and hybridized to Affymetrix GeneChip(R) Porcine Genome Arrays. Differences in gene expression were observed with respect to sampling time. Ingenuity Pathways Analysis revealed seven common biological functions among the top ten functions of each time point, while canonical pathway analysis revealed 3 genes (IL-6, IL1A, and IL1B) were commonly shared among three significantly altered signaling pathways. The transcripts encoding all three genes were identified as common potential therapeutic targets for Phase II/III clinical trial, or FDA-approved drugs. The present study shows transcriptional profiling of cutaneous wounds induced by chlorine exposure identified potential targets for developing therapeutics against chlorine-induced skin injury. C1 [Price, Jennifer A.; Rogers, James V.; Plahovinsak, Jennifer L.; Wendling, Morgan Q. S.; Perry, Mark R.; Reid, Frances M.] Battelle Biomed Res Ctr, Columbus, OH 43201 USA. [Graham, John S.] USA, Med Res Inst Chem Def, Commanders Off, Aberdeen Proving Ground, MD 21010 USA. RP Price, JA (reprint author), Battelle Biomed Res Ctr, 505 King Ave,JM-7, Columbus, OH 43201 USA. EM priceja@battelle.org FU DTRA/CBMS/MRMC [W81XWH-05-D-0001]; U.S. Army Medical Research Institute of Chemical Defense (USAMRICD); National Institutes of Health, National Institute of Allergies and Infectious Disease (NIAID), IAA [Y1-AI-6177-02] FX This work was conducted under DTRA/CBMS/MRMC Contract W81XWH-05-D-0001, Task Order 0010 with funding support through an Interagency Agreement (IAA) between the U.S. Army Medical Research Institute of Chemical Defense (USAMRICD) and National Institutes of Health, National Institute of Allergies and Infectious Disease (NIAID), IAA Number Y1-AI-6177-02. The views, opinions, and/or findings contained in this report are those of the authors and should not be construed as an official Department of the Army position, policy, or decision unless so designated by other documentation. The experimental protocol was approved by the Animal Care and Use Committee at Battelle Memorial Institute and the US Army Medical Research and Materiel Command's Animal Care and Use Review Office. All procedures were conducted in accordance with the principles stated in the Guide for the Care and Use of Laboratory Animals (National Research Council, 1996), and the Animal Welfare Act of 1966 (P. L. 89-544), as amended. NR 59 TC 1 Z9 1 U1 0 U2 7 PU INFORMA HEALTHCARE PI LONDON PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND SN 1556-9527 J9 CUTAN OCUL TOXICOL JI Cutan. Ocul. Toxicol. PD DEC PY 2012 VL 31 IS 4 BP 323 EP 331 DI 10.3109/15569527.2012.679374 PG 9 WC Ophthalmology; Toxicology SC Ophthalmology; Toxicology GA 032HL UT WOS:000310705800009 PM 22533443 ER PT J AU Huang, XZ Chahine, MA Frye, JG Cash, DM Lesho, EP Craft, DW Lindler, LE Nikolich, MP AF Huang, X. -Z. Chahine, M. A. Frye, J. G. Cash, D. M. Lesho, E. P. Craft, D. W. Lindler, L. E. Nikolich, M. P. TI Molecular analysis of imipenem-resistant Acinetobacter baumannii isolated from US service members wounded in Iraq, 2003-2008 SO EPIDEMIOLOGY AND INFECTION LA English DT Article DE A. baumannii; imipenem resistance; OXA-23 ID MEDICAL-CENTER; MILITARY; STRAINS; SPREAD; GENES AB Global dissemination of imipenem-resistant (IR) clones of Acinetobacter baumannii-A. calcoaceticus complex (ABC) have been frequently reported but the molecular epidemiological features of IR-ABC in military treatment facilities (MTFs) have not been described. We characterized 46 IR-ABC strains from a dataset of 298 ABC isolates collected from US service members hospitalized in different US MTFs domestically and overseas during 2003-2008. All IR strains carried the bla(OXA-51) gene and 40 also carried bla(OXA-23) on plasmids and/or chromosome; one carried bla(OXA-58) and four contained ISAbal located upstream of bla(OXA-51). Strains tended to cluster by pulsed-field gel electrophoresis profiles in time and location. Strains from two major clusters were identified as international clone I by multilocus sequence typing. C1 [Huang, X. -Z.; Chahine, M. A.; Cash, D. M.; Lesho, E. P.; Craft, D. W.; Nikolich, M. P.] Walter Reed Army Inst Res, Div Bacterial & Rickettsial Dis, Silver Spring, MD 20910 USA. [Frye, J. G.] ARS, Bacterial Epidemiol & Antimicrobial Resistance Re, USDA, Athens, GA USA. [Lindler, L. E.] Dept Homeland Secur, Chem Biol Def Div, Sci & Technol Directorate, Washington, DC USA. RP Huang, XZ (reprint author), Walter Reed Army Inst Res, Div Bacterial & Rickettsial Dis, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM xiaozhe.huang1.ctr@us.army.mil RI Valle, Ruben/A-7512-2013; Frye, Jonathan/I-6382-2013 OI Frye, Jonathan/0000-0002-8500-3395 FU DoD-Global Emerging Infections Surveillance and Response System (GEIS) FX We thank Tacita Hamilton for part of the PFGE technical support. Mark Adams provided advice on identification of the AbaR4 resistance island. This work was funded by the DoD-Global Emerging Infections Surveillance and Response System (GEIS). The findings and opinions expressed herein are those of the authors and do not necessarily reflect the official views of the WRAIR, the US Army, the Department of Defense, the US Department of Agriculture or the Department of Homeland Security. The mention of trade names or commercial products in this article is solely for the purpose of providing specific information and does not imply recommendation or endorsement by the US Department of Agriculture. NR 19 TC 8 Z9 9 U1 2 U2 12 PU CAMBRIDGE UNIV PRESS PI NEW YORK PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA SN 0950-2688 J9 EPIDEMIOL INFECT JI Epidemiol. Infect. PD DEC PY 2012 VL 140 IS 12 BP 2302 EP 2307 DI 10.1017/S0950268811002871 PG 6 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA 031IC UT WOS:000310631700020 PM 22273504 ER PT J AU Mumford, MD Friedrich, TL Vessey, WB Ruark, GA AF Mumford, Michael D. Friedrich, Tamara L. Vessey, William B. Ruark, Gregory A. TI Collective Leadership: Thinking About Issues Vis-a-Vis Others SO INDUSTRIAL AND ORGANIZATIONAL PSYCHOLOGY-PERSPECTIVES ON SCIENCE AND PRACTICE LA English DT Article C1 [Mumford, Michael D.] Univ Oklahoma, Dept Psychol, Norman, OK 73019 USA. [Friedrich, Tamara L.] Savannah State Univ, Savannah, GA USA. [Ruark, Gregory A.] USA, Res Inst, Washington, DC USA. RP Mumford, MD (reprint author), Univ Oklahoma, Dept Psychol, Norman, OK 73019 USA. EM mmumford@ou.edu NR 12 TC 8 Z9 8 U1 2 U2 12 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1754-9426 J9 IND ORGAN PSYCHOL-US JI Ind. Organ. Psychol. PD DEC PY 2012 VL 5 IS 4 BP 408 EP 411 DI 10.1111/j.1754-9434.2012.01469.x PG 4 WC Psychology, Applied SC Psychology GA 030EC UT WOS:000310550900004 ER PT J AU Costanza, DP Badger, JM Fraser, RL Severt, JB Gade, PA AF Costanza, David P. Badger, Jessica M. Fraser, Rebecca L. Severt, Jamie B. Gade, Paul A. TI Generational Differences in Work-Related Attitudes: A Meta-analysis SO JOURNAL OF BUSINESS AND PSYCHOLOGY LA English DT Article DE Generational differences; Meta-analysis; Job satisfaction; Organizational commitment; Intent to turnover ID JOB-SATISFACTION RELATIONSHIP; BIRTH COHORT DIFFERENCES; LIFE-COURSE; BABY BOOMERS; PERSONALITY-DEVELOPMENT; MULTIVARIATE-ANALYSIS; SOCIAL-CHANGE; AGE; TURNOVER; VALIDITY AB Purpose Differences among generations on a wide variety of outcomes are of increasing interest to organizations, practitioners, and researchers alike. The goal of this study was to quantitatively assess the research on generational differences in work-related attitudes and to provide guidance for future research and practice. Design/Methodology/Approach We conducted a meta-analysis of generational differences on three work-related criteria: job satisfaction, organizational commitment, and intent to turnover. Our review of published and unpublished research found 20 studies allowing for 18 generational pairwise comparisons across four generations (Traditionals, Baby Boomers, Generation Xers, and Millennials) on these outcomes using 19,961 total subjects. Findings Corrected mean differences for job satisfaction ranged from .02 to .25, for organizational commitment they ranged from -.22 to .46, and for intent to turnover the range was -.62 to .05. The pattern of results indicates that the relationships between generational membership and work-related outcomes are moderate to small, essentially zero in many cases. Implications The findings suggest that meaningful differences among generations probably do not exist on the work-related variables we examined and that the differences that appear to exist are likely attributable to factors other than generational membership. Given these results, targeted organizational interventions addressing generational differences may not be effective. Originality/Value This is the first known quantitative review of research on generational differences in the workplace. C1 [Costanza, David P.; Badger, Jessica M.; Fraser, Rebecca L.; Severt, Jamie B.] George Washington Univ, Dept Org Sci & Commun, Washington, DC 20052 USA. [Gade, Paul A.] USA, Res Inst Behav & Social Sci, Arlington, VA USA. RP Costanza, DP (reprint author), George Washington Univ, Dept Org Sci & Commun, 600 21st St NW,201, Washington, DC 20052 USA. EM dcostanz@gwu.edu NR 101 TC 34 Z9 36 U1 8 U2 120 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0889-3268 J9 J BUS PSYCHOL JI J. Bus. Psychol. PD DEC PY 2012 VL 27 IS 4 BP 375 EP 394 DI 10.1007/s10869-012-9259-4 PG 20 WC Business; Psychology, Applied SC Business & Economics; Psychology GA 033QC UT WOS:000310812000001 ER PT J AU Lunday, BJ Sherali, HD AF Lunday, B. J. Sherali, H. D. TI Minimizing the maximum network flow: models and algorithms with resource synergy considerations SO JOURNAL OF THE OPERATIONAL RESEARCH SOCIETY LA English DT Article DE network interdiction; synergy; resource allocation; inner-linearization; outer-approximation ID OPTIMAL INTERDICTION; OPTIMIZATION AB In this paper, we model and solve the network interdiction problem of minimizing the maximum flow through a network from a given source node to a terminus node, while incorporating different forms of superadditive synergy effects of the resources applied to the arcs in the network. Within this context, we examine linear, concave, and convex-concave synergy relationships, illustrate their relative effect on optimal solution characteristics, and accordingly develop and test effective solution procedures for the underlying problems. For a concave synergy relationship, which yields a convex programme, we propose an inner-linearization procedure that significantly outperforms the competitive commercial solver SBB by improving the quality of solutions found by the latter by 6.2% (within a time limit of 1800 CPUs), while saving 84.5% of the required computational effort. For general non-concave synergy relationships, we develop an outer-approximation-based heuristic that achieves solutions of objective value 0.20% better than the commercial global optimization software BARON, with a 99.3% reduction in computational effort for the subset of test problems for which BARON could identify a feasible solution within the set time limit. Journal of the Operational Research Society (2012) 63, 1693-1707. doi:10.1057/jors.2012.8 Published online 7 March 2012 C1 [Lunday, B. J.] US Mil Acad, Dept Math Sci, West Point, NY 10996 USA. [Sherali, H. D.] Virginia Tech, Grado Dept Ind & Syst Engn, Blacksburg, VA USA. RP Lunday, BJ (reprint author), US Mil Acad, Dept Math Sci, West Point, NY 10996 USA. OI Lunday, Brian/0000-0001-5191-4361 FU National Science Foundation [CMMI-0969169]; Army Research Office FX This work is partially supported by the National Science Foundation under Grant No. CMMI-0969169, acknowledge Dr Nick Sahinidis of the Sahinidis Optimization Group at Carnegie an Omar Nelson Bradley Fellowship in Mathematics, and by the Army Research Office. The authors gratefully Mellon University for permitting the use of the AlphaECP, BARON, CoinBonmin, DICOPT, and SBB solvers. The authors also thank the Associate Editor and three referees for their detailed and constructive comments that have greatly helped improve the presentation of this paper. NR 29 TC 0 Z9 0 U1 0 U2 9 PU PALGRAVE MACMILLAN LTD PI BASINGSTOKE PA BRUNEL RD BLDG, HOUNDMILLS, BASINGSTOKE RG21 6XS, HANTS, ENGLAND SN 0160-5682 J9 J OPER RES SOC JI J. Oper. Res. Soc. PD DEC PY 2012 VL 63 IS 12 BP 1693 EP 1707 DI 10.1057/jors.2012.8 PG 15 WC Management; Operations Research & Management Science SC Business & Economics; Operations Research & Management Science GA 033JP UT WOS:000310791800005 ER PT J AU Wiecha, JL Hall, G Gannett, E Roth, B AF Wiecha, Jean L. Hall, Georgia Gannett, Ellen Roth, Barbara TI Development of Healthy Eating and Physical Activity Quality Standards for Out-of-School Time Programs SO CHILDHOOD OBESITY LA English DT Article AB Background: Out-of-school time (OST) programs serve over 8 million children per year and have ample opportunity to promote health through menu and physical activity choices. Until recently, however, the field has lacked a comprehensive set of operationalizable standards for healthy eating and physical activity. The National AfterSchool Association adopted voluntary healthy eating and physical activity quality standards (HEPAQS) in April, 2011. Methods: We describe the development of HEPAQS. This work reflects a social ecological model for changing children's eating and activity behaviors through program-level interventions. The standards were developed using a national, mixed-methods needs assessment, review of existing standards and expert recommendations, and a participatory process of discussion, review, and consensus engaging 19 influential service and policy organizations and agencies in the Healthy Out-of-School Time (HOST) coalition, which we convened in 2009. Results: The HOST coalition approved a final version of the HEPAQS in January, 2011. The 11 standards address content, curriculum selection, staff training, program support, and environmental support for healthy eating and physical activity. In April, 2011, the HEPAQS were adopted by the National AfterSchool Association, and have subsequently been widely disseminated. Extensive adoption and implementation efforts are underway. Conclusions: The availability of a comprehensive set of standards for healthy eating and physical activity in OST provides practical information to help community-based youth-serving organizations participate in obesity and chronic disease prevention. A working awareness of their content will be useful to scientists undertaking health promotion studies in the out-of-school time setting. C1 [Wiecha, Jean L.] Univ Massachusetts, Dept Exercise & Hlth Sci, Boston, MA 02125 USA. [Hall, Georgia; Gannett, Ellen] Wellesley Coll, Natl Inst Out Of Sch Time, Wellesley, MA 02181 USA. [Roth, Barbara] USA, YMCA, Chicago, IL USA. RP Wiecha, JL (reprint author), RTI Int, Primary Prevent Res & Evaluat Program, 1440 Main St, Waltham, MA 02451 USA. EM jwiecha@rti.org FU Robert Wood Johnson Foundation [67296] FX The authors are grateful to all members of the HOST coalition for their participation in developing the standards. Elements of this project were supported by a grant from the Robert Wood Johnson Foundation to Wellesley College: Robert Wood Johnson Foundation Grant 67296 to Dr. Hall (Principal Investigator) and Dr. Wiecha (Co-Principal Investigator). NR 20 TC 11 Z9 11 U1 2 U2 15 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 2153-2168 EI 2153-2176 J9 CHILD OBES JI Child Obes. PD DEC PY 2012 VL 8 IS 6 BP 572 EP 576 DI 10.1089/chi.2012.0030 PG 5 WC Pediatrics SC Pediatrics GA V32JL UT WOS:000208947400009 PM 23181923 ER PT J AU Welton, MD AF Welton, Mark D. TI Islamic Law and Civil Code: The Law of Property in Egypt SO MIDDLE EAST JOURNAL LA English DT Book Review C1 [Welton, Mark D.] US Mil Acad, West Point, NY 10996 USA. RP Welton, MD (reprint author), US Mil Acad, West Point, NY 10996 USA. NR 1 TC 0 Z9 0 U1 0 U2 1 PU MIDDLE EAST INST PI WASHINGTON PA 1761 N ST NW, CIRCULATION DEPT, WASHINGTON, DC 20036-2882 USA SN 0026-3141 J9 MIDDLE EAST J JI Middle East J. PD WIN PY 2012 VL 66 IS 1 BP 189 EP 190 PG 2 WC Area Studies SC Area Studies GA V31XK UT WOS:000208916100030 ER PT J AU Gonsalves, S Stavinoha, T Hite, L Costa, J Dilly, G Deuster, PA AF Gonsalves, Stephen Stavinoha, Trisha Hite, Linda Costa, Janelle Dilly, George Deuster, Patricia A. TI Dietary Supplements in the Department of Defense: Possible Solutions to Optimizing Force Readiness SO MILITARY MEDICINE LA English DT Article AB Dietary supplement use is common among military service members; approximately 17 to 20% report using high-risk weight-loss, performance-enhancing, and bodybuilding supplements. To date, no overarching policy or program has been approved or implemented to inform service members or educate health care providers on the potential adverse consequences of using multiple combinations of supplements or the pros and cons of supplements per se. A review of regulations, concerns, and possible solutions is provided. Importantly, the role of third-party certification and education is emphasized. C1 [Gonsalves, Stephen; Deuster, Patricia A.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [Stavinoha, Trisha] Evans Army Community Hosp, Ft Carson, CO 80913 USA. [Hite, Linda] MCICOM G4, Installat & Logist Dept, Washington, DC 20380 USA. [Costa, Janelle] Joint Base San Antonio Lackland, Wilford Hall Ambulatory Surg Ctr, Lackland AFB, TX 78236 USA. [Dilly, George] US Army, Med Command, Ancillary Hlth Div, Ft Sam Houston, TX 78234 USA. RP Gonsalves, S (reprint author), Uniformed Serv Univ Hlth Sci, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA. RI Deuster, Patricia/G-3838-2015 OI Deuster, Patricia/0000-0002-7895-0888 FU Center Alliance for Dietary Supplement Research, Defense Health Program FX We gratefully acknowledge the financial support provided by the Center Alliance for Dietary Supplement Research, Defense Health Program. NR 74 TC 1 Z9 1 U1 1 U2 6 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD DEC PY 2012 VL 177 IS 12 BP 1464 EP 1470 DI 10.7205/MILMED-D-12-00249 PG 7 WC Medicine, General & Internal SC General & Internal Medicine GA V33OG UT WOS:000209027500012 PM 23397690 ER PT J AU Lewis, PC Holcomb, B AF Lewis, Paul C. Holcomb, Barbara TI A Model for Patient-Centered Army Primary Care SO MILITARY MEDICINE LA English DT Article AB This pilot evaluated a novel method of primary care delivery in a military family practice setting. A registered nurse, registered nurse case manager, and primary care provider formed the patient management team. Approximately 2,500 empanelled patients participated in a pilot program that applied a patient-centered approach to primary care. The pilot tracked outcome measures, which included (1) panel size, (2) access to care, (3) care utilization, (4) continuity of care, (5) nurse and provider productivity, (6) Healthcare Effectiveness Data and Information Set measures, and (7) satisfaction measures. When compared to the standard family practice clinic, the patients in the pilot were able to access the family practice clinic more frequently (p < 0.05), were less seen in the urgent care (p < 0.05), and had a lower no-show rate (p < 0.001) for scheduled appointments. The providers were able to see their own empanelled patients significantly more frequently (p < 0.05) and virtually all Healthcare Effectiveness Data and Information Set markers improved with colon cancer screening, low-density lipoprotein annual exams, low-density lipoprotein control, and breast cancer screening/mammogram being significantly improved over the comparison group (p < 0.05). These results suggest a change in staffing and a focus on patient-centered care can significantly improve outpatient care access and population health maintenance. C1 [Lewis, Paul C.] Uniformed Serv Univ Hlth Sci, Grad Sch Nursing, Bethesda, MD 20814 USA. [Holcomb, Barbara] US Army, Dept 260, AHR COPH N, Human Resources Command, Ft Knox, KY 40122 USA. RP Lewis, PC (reprint author), Uniformed Serv Univ Hlth Sci, Grad Sch Nursing, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA. FU Army Medical Command FX Army Medical Command provided financial support for this project. Funding was used primarily to reimburse cost to hire personnel. NR 22 TC 3 Z9 3 U1 2 U2 5 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD DEC PY 2012 VL 177 IS 12 BP 1502 EP 1507 DI 10.7205/MILMED-D-12-00076 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA V33OG UT WOS:000209027500018 PM 23397696 ER PT J AU Bryce, L Koenig, M Jerke, KH AF Bryce, Louise Koenig, Michael Jerke, Kurt H. TI A Large-Scale Study of Respiratory Virus Infection Over 2 Years Using the Luminex xTAGRVP Assay SO MILITARY MEDICINE LA English DT Article AB Traditional methods of detecting and identifying respiratory viruses like cell culture and immunofluorescence are labor intensive, often slow, and are dependent on specimen viability. As a result, there has been a shift in laboratory practices from these methods to molecular-based techniques such as polymerase chain reaction, which can be faster, more sensitive, and less labor intensive than traditional methods. The Food and Drug Administration approved version of the Luminex xTAG respiratory viral panel (RVP) assay detects 12 respiratory viruses simultaneously. We evaluated the performance of the RVP assay, on over 8,000 nasopharyngeal specimens during a 2-year period. Approximately 70% of all specimens tested were positive for at least one respiratory virus. Influenza A (Inf A) was the most prevalent, followed by respiratory syncytial virus. The RVP assay also detected the newly emerging Inf A porcine H1N1 that started to circulate in 2008. However, it could not identify it to subtype level and required further confirmatory tests. This study shows that the RVP assay is an invaluable tool in monitoring seasonal outbreaks and pandemic events. It not only detects newly emerging influenza strains, but also allows the throughput of thousands of clinical specimens in a timely manner, reducing the turnaround time from weeks to days, when compared to cell culture. C1 [Bryce, Louise; Koenig, Michael] Landstuhl Reg Med Ctr, Dept Pathol & Area Lab Serv, D-66849 Landstuhl, Kirchberg, Germany. [Jerke, Kurt H.] US Army, Res Inst Infect Dis, Virol Div, Ft Detrick, MD 21702 USA. RP Bryce, L (reprint author), Landstuhl Reg Med Ctr, Dept Pathol & Area Lab Serv, Dr Hitzelberger Str, D-66849 Landstuhl, Kirchberg, Germany. FU Armed Forces Health Surveillance Center's Division of Global Emerging Infections Surveillance Operations [I0320_12_MC] FX This work was funded by the Armed Forces Health Surveillance Center's Division of Global Emerging Infections Surveillance Operations grant number I0320_12_MC. NR 21 TC 1 Z9 2 U1 0 U2 0 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD DEC PY 2012 VL 177 IS 12 BP 1533 EP 1538 DI 10.7205/MILMED-D-12-00277 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA V33OG UT WOS:000209027500023 PM 23397701 ER PT J AU Gegel, B Burgert, J Gasko, J Campbell, C Martens, M Keck, J Reynolds, H Loughren, M Johnson, D AF Gegel, Brian Burgert, James Gasko, John Campbell, Christian Martens, Mark Keck, Joseph Reynolds, Harmony Loughren, Michael Johnson, Don TI The Effects of QuikClot Combat Gauze and Movement on Hemorrhage Control in a Porcine Model SO MILITARY MEDICINE LA English DT Article AB The purpose of this study was twofold: (1) to examine the effectiveness of QuikClot Combat Gauze (QCG) compared to a control group and (2) investigate the effect of movement on hemorrhage control when QCG is employed. This was a prospective, experimental design employing an established porcine model of uncontrolled hemorrhage. The minimum number of animals (n = 11 per group) was used to obtain a statistically valid result. There were no statistically significant differences between the groups (p > 0.05) indicating that the groups were equivalent on the following parameters: activating clotting time, the subject weights, core body temperatures, amount of 1 minute hemorrhage, arterial blood pressures, and the amount and percentage of total blood volume. There were significant differences in the amount of hemorrhage (p = 0.018) and the number of movements (p = 0.000) between the QCG and control. QCG is statistically and clinically superior at controlling hemorrhage compared to the standard pressure dressing control group. Furthermore, it produces a more robust clot that can withstand significant movement. In conclusion, QCG is an effective hemostatic agent for use in civilian and military trauma management. C1 [Gegel, Brian] Vet Anesthesia Serv, San Antonio, TX 78269 USA. [Burgert, James] San Antonio Mil Med Ctr, Dept Anesthesia, San Antonio, TX 78234 USA. [Gasko, John; Campbell, Christian; Martens, Mark; Keck, Joseph; Reynolds, Harmony; Johnson, Don] US Army, Grad Program Anesthesia Nursing, Dept Army Acad Hlth Sci, Ft Sam Houston, TX 78234 USA. [Loughren, Michael] Madigan Army Med Ctr, Tacoma, WA 98431 USA. RP Gegel, B (reprint author), Vet Anesthesia Serv, POB 691286, San Antonio, TX 78269 USA. OI Burgert, James/0000-0001-8346-6196 FU Triservice Nursing Research Program FX The authors acknowledge the Triservice Nursing Research Program for funding our investigation, the University of Texas Health Science Center at San Antonio for laboratory support, and the U.S. Army Graduate Program in Anesthesia Nursing [HU0001-09-1-TS12 (N09C01)]. NR 31 TC 4 Z9 4 U1 0 U2 5 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD DEC PY 2012 VL 177 IS 12 BP 1543 EP 1547 DI 10.7205/MILMED-D-12-00165 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA V33OG UT WOS:000209027500025 PM 23397703 ER PT J AU Isayev, O Crespo-Hernandez, CE Gorb, L Hill, FC Leszczynski, J AF Isayev, Olexandr Crespo-Hernandez, Carlos E. Gorb, Leonid Hill, Frances C. Leszczynski, Jerzy TI In silico structure-function analysis of E. cloacae nitroreductase SO PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS LA English DT Article DE flavoproteins; bioinformatics; molecular dynamics; flexibility prediction; structure-function relationship; principal component analysis ID ESCHERICHIA-COLI NITROREDUCTASE; FMN-DEPENDENT NITROREDUCTASE; PRODRUG-ACTIVATING ENZYME; NITROAROMATIC COMPOUNDS; ENTEROBACTER-CLOACAE; 2-ELECTRON REDUCTION; NAD(P)H NITROREDUCTASE; MOLECULAR-DYNAMICS; CRYSTAL-STRUCTURE; PROTEIN AB Reduction, catalyzed by the bacterial nitroreductases, is the quintessential first step in the biodegradation of a variety of nitroaromatic compounds from contaminated waters and soil. The Enterobacter cloacae nitroreductase (EcNR) enzyme is considered as a prospective biotechnological tool for bioremediation of hazardous nitroaromatic compounds. Using diverse computational methods, we obtain insights into the structural basis of activity and mechanism of its function. We have performed molecular dynamics simulation of EcNR in three different states (free EcNR in oxidized form, fully reduced EcNR with benzoate inhibitor and fully reduced EcNR with nitrobenzene) in explicit solvent and with full electrostatics. Principal Component Analysis (PCA) of the variance-covariance matrix showed that the complexed nitroreductase becomes more flexible overall upon complexation, particularly helix H6, in the vicinity of the binding site. A multiple sequence alignment was also constructed in order to examine positional constraints on substitution in EcNR. Five regions which are highly conserved within the flavin mononucleotide (FMN) binding site were identified. Obtained results and their implications for EcNR functioning are discussed, and new plausible mechanism has been proposed. C1 [Isayev, Olexandr; Crespo-Hernandez, Carlos E.] Case Western Reserve Univ, Dept Chem, Cleveland, OH 44106 USA. [Isayev, Olexandr; Hill, Frances C.; Leszczynski, Jerzy] USA, Environm Lab, Erdc, Vicksburg, MS 39180 USA. [Gorb, Leonid] Badger Tech Serv, San Antonio, TX 78216 USA. [Leszczynski, Jerzy] Jackson State Univ, Dept Chem & Biochem, Interdisciplinary Ctr Nanotox, Jackson, MS 39217 USA. RP Isayev, O (reprint author), Case Western Reserve Univ, Dept Chem, Cleveland, OH 44106 USA. EM olexandr@olexandrisayev.com RI Crespo-Hernandez, Carlos/A-9915-2008; OI Crespo-Hernandez, Carlos/0000-0002-3594-0890; Isayev, Olexandr/0000-0001-7581-8497 FU Extreme Science and Engineering Discovery Environment (XSEDE) (National Science Foundation) [OCI-1053575]; XSEDE [DMR110088]; ERDC [W912HZ-11-1-0003]; American Chemical Society Petroleum Research Fund; Environmental Quality Technology Program of the United States Army Corps of Engineers by the US Army ERDC FX Grant sponsor: Extreme Science and Engineering Discovery Environment (XSEDE) (National Science Foundation); Grant number: OCI-1053575; Grant sponsor: XSEDE; Grant number: DMR110088; Grant sponsor: ERDC; Grant number: W912HZ-11-1-0003; Grant sponsor: American Chemical Society Petroleum Research Fund; The authors would like to thank Jacques Reifmann and the rest of his group at The Biotechnology High Performance Computing Software Application Institute (BHSAI) for their generous allotment of time, and the Army Research Laboratory (ARL), the Engineering Research and Development Center (ERDC) for the use of their computational resources. The use of trade, product, or firm names in this report is for descriptive purposes only and does not imply endorsement by the U.S. Government. Results in this study were funded and obtained from research conducted under the Environmental Quality Technology Program of the United States Army Corps of Engineers by the US Army ERDC. Permission was granted by the Chief of Engineers to publish this information. The findings of this report are not to be construed as an official Department of the Army position unless so designated by other authorized documents. NR 64 TC 3 Z9 3 U1 1 U2 29 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0887-3585 J9 PROTEINS JI Proteins PD DEC PY 2012 VL 80 IS 12 BP 2728 EP 2741 DI 10.1002/prot.24157 PG 14 WC Biochemistry & Molecular Biology; Biophysics SC Biochemistry & Molecular Biology; Biophysics GA 030EP UT WOS:000310552400008 PM 22865652 ER PT J AU Malinovsky, VS Rudin, S AF Malinovsky, V. S. Rudin, S. TI Ultrafast control of electron spin in a quantum dot using geometric phase SO SOLID-STATE ELECTRONICS LA English DT Article DE Quantum dot; Electron-spin qubit; Geometrical phase ID COMPUTATION; PULSES AB We propose a scheme to perform arbitrary unitary operations on a single electron-spin qubit in a quantum dot. The design is solely based on the geometrical phase that the qubit state acquires after a cyclic evolution in the parameter space. The scheme is utilizing ultrafast linearly-chirped pulses providing adiabatic excitation of the qubit states and the geometric phase is fully controlled by the relative phase between pulses. The analytic expression of the evolution operator for the electron spin in a quantum dot, which provides a clear geometrical interpretation of the qubit dynamics is obtained. Using parameters of InGal\l/GaN, GaN/AlN quantum dots we provide an estimate for the time scale of the qubit rotations and parameters of the external fields. (C) 2012 Elsevier Ltd. All rights reserved. C1 [Malinovsky, V. S.; Rudin, S.] USA, Res Lab, Adelphi, MD 20783 USA. RP Malinovsky, VS (reprint author), USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM vsmalinovsky@gmail.com; sergey.i.rudin.civ@mail.mil NR 26 TC 1 Z9 1 U1 1 U2 4 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0038-1101 EI 1879-2405 J9 SOLID STATE ELECTRON JI Solid-State Electron. PD DEC PY 2012 VL 78 SI SI BP 28 EP 33 DI 10.1016/j.sse.2012.05.039 PG 6 WC Engineering, Electrical & Electronic; Physics, Applied; Physics, Condensed Matter SC Engineering; Physics GA 013OB UT WOS:000309313600006 ER PT J AU Rupper, G Rudin, S Crowne, FJ AF Rupper, Greg Rudin, Sergey Crowne, Frank J. TI Effects of oblique wave propagation on the nonlinear plasma resonance in the two-dimensional channel of the Dyakonov-Shur detector SO SOLID-STATE ELECTRONICS LA English DT Article DE Plasma resonance; Terahertz detector; Plasma waves; Field effect transistor ID FIELD-EFFECT TRANSISTOR; CONDUCTION CHANNELS; TERAHERTZ RADIATION; ELECTRONS; TRANSPORT; FLUID AB In the Dyakonov-Shur terahertz detector the conduction channel of a heterostructure High Electron Mobility Transistor (HEMT) is used as a plasma wave resonator for density oscillations in electron gas. Nonlinearities in the plasma wave propagation lead to a constant source-to-drain voltage, providing the detector output. In this paper, we start with the quasi-classical Boltzmann equation and derive the hydrodynamic model with temperature dependent transport coefficients for a two-dimensional viscous flow. This derivation allows us to obtain the parameters for the hydrodynamic model from the band-structure of the HEMT channel. The treatment here also includes the energy balance equation into the analysis. By numerical solution of the hydrodynamic equations with a non-zero boundary current we evaluate the detector response function and obtain the temperature dependence of the plasma resonance. The present treatment extends the theory of Dyakonov-Shur plasma resonator and detector to account for the temperature dependence of viscosity, the effects of oblique wave propagation on detector response, and effects of boundary current in two-dimensional flow on quality of the plasma resonance. The numerical results are given for a GaN channel. We also investigated a stability of source to drain flow and formation of shock waves. Published by Elsevier Ltd. C1 [Rupper, Greg; Rudin, Sergey; Crowne, Frank J.] USA, Res Lab, Adelphi, MD 20783 USA. RP Rudin, S (reprint author), USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM sergey.i.rudin.civ@mail.mil NR 20 TC 5 Z9 5 U1 1 U2 11 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0038-1101 J9 SOLID STATE ELECTRON JI Solid-State Electron. PD DEC PY 2012 VL 78 SI SI BP 102 EP 108 DI 10.1016/j.sse.2012.05.052 PG 7 WC Engineering, Electrical & Electronic; Physics, Applied; Physics, Condensed Matter SC Engineering; Physics GA 013OB UT WOS:000309313600019 ER PT J AU Shah, PB Dedhia, RH Tompkins, RP Viveiros, EA Jones, KA AF Shah, P. B. Dedhia, R. H. Tompkins, R. P. Viveiros, E. A. Jones, K. A. TI DLTS and MCTS analysis of the influence of growth pressure on trap generation in MOCVD GaN SO SOLID-STATE ELECTRONICS LA English DT Article DE HEMT; GaN; DLTS; Carbon; MOCVD; Trap; Amphoteric ID ELECTRON-MOBILITY TRANSISTORS; MOLECULAR-BEAM EPITAXY; VAPOR-PHASE EPITAXY; N-TYPE GAN; DEEP LEVELS; YELLOW LUMINESCENCE; HOLE TRAPS; CARBON; FILMS; SILICON AB We demonstrate with DLTS and MCTS how changing growth pressure during MOCVD growth of GaN affects the majority and minority carrier trap signatures. Results indicate which specific traps are most strongly connected with the increased carbon concentration that lower growth pressure has led to. Carbon concentration is also verified with SIMS measurements. DLTS and MCTS measurements, related to carrier thermalization from traps, made up to a temperature of 450 K have found four majority carrier and two minority carrier traps. Using a lower growth pressures, at which greater incorporation of carbon is possible, has lead to larger concentrations of most of the traps: just as others have observed. However, the trap at E-C - 0.48 eV is the least affected by the growth pressure. We relate all the traps found from DLTS and MCTS to those identified by others and mention the constituent atoms that the research community identifies with these traps. Published by Elsevier Ltd. C1 [Shah, P. B.] USA, Res Lab, Sensors & Electron Devices Directorate, RDRL SER E, Adelphi, MD 20783 USA. RP Shah, PB (reprint author), USA, Res Lab, Sensors & Electron Devices Directorate, RDRL SER E, Adelphi, MD 20783 USA. EM pankaj.b.shah.civ@mail.mil NR 32 TC 6 Z9 6 U1 5 U2 55 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0038-1101 J9 SOLID STATE ELECTRON JI Solid-State Electron. PD DEC PY 2012 VL 78 SI SI BP 121 EP 126 DI 10.1016/j.sse.2012.05.057 PG 6 WC Engineering, Electrical & Electronic; Physics, Applied; Physics, Condensed Matter SC Engineering; Physics GA 013OB UT WOS:000309313600022 ER PT J AU Shukla, MK Hill, F AF Shukla, Manoj K. Hill, Frances TI Theoretical investigation of reaction mechanisms of alkaline hydrolysis of 2,3,6-trinitro-beta-D-glucopyranose as a monomer of nitrocellulose SO STRUCTURAL CHEMISTRY LA English DT Article DE Nitrocellulose; B3LYP; MP2; Transition state; Alkaline hydrolysis; 2,3,6-Trinitro-beta-D-glucopyranose ID IMPACT SENSITIVITIES; CELLULOSE NITRATE; EXPLOSIVES; DEGRADATION; KINETICS; DISSOCIATION AB The 2,3,6-trinitro-beta-d-glucopyranose as a monomer of nitrocellulose in the C-4(1) chair conformation was selected for the alkaline hydrolysis of nitrocellulose within S(N)2 framework in the gas phase and in the bulk water solution. Both the direct and angular attacks of OH- in the hydrolysis reactions were considered. Geometries were optimized at the B3LYP/6-311G(d,p) level both in the gas phase and in bulk water solution. Effect of bulk water solution was modeled using the PCM approach. Nature of potential energy surfaces of the local minima and transition states was ascertained through harmonic vibrational frequency analysis. Intrinsic reaction coordinate calculations were also performed to validate the computed transition state structures. Effect of electron correlation on computed energies was considered at the MP2/cc-pVTZ//B3LYP/6-311G(d,p) level. It was found that the angular attack of OH- in the hydrolysis reaction will require significantly larger activation energy than the direct attack. Computed transition states correspond to the structure where the presence of hydrogen bonds between the OH- and various sites of nitrocellulose was the necessary stabilizing factor. The ring breaking through the C-O ring bond was not found to be the first step in the alkaline hydrolysis reactions. It was predicted that alkaline hydrolysis would be driven by the addition-elimination (substitution) reaction starting at the C3 site and will progress in the C2 -> C6 direction. Entropy of system in water solution will have profound effect on alkaline hydrolysis reaction of nitrocellulose. C1 [Shukla, Manoj K.; Hill, Frances] USA, Engn Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA. RP Shukla, MK (reprint author), USA, Engn Res & Dev Ctr, Environm Lab, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM manoj.k.shukla@usace.army.mil NR 31 TC 4 Z9 4 U1 0 U2 7 PU SPRINGER/PLENUM PUBLISHERS PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1040-0400 J9 STRUCT CHEM JI Struct. Chem. PD DEC PY 2012 VL 23 IS 6 BP 1905 EP 1920 DI 10.1007/s11224-012-9977-2 PG 16 WC Chemistry, Multidisciplinary; Chemistry, Physical; Crystallography SC Chemistry; Crystallography GA 028NA UT WOS:000310427900026 ER PT J AU Lindsay, DL Bailey, P Anderson, JL Jung, MG Edwards, CE Lance, RF AF Lindsay, Denise L. Bailey, Pamela Anderson, Joseph L. Jung, Michael G. Edwards, Christine E. Lance, Richard F. TI Isolation and characterization of microsatellite loci for a hyper-rare cliff endemic, Erigeron lemmonii, and a more widespread congener, Erigeron arisolius (Asteraceae) SO CONSERVATION GENETICS RESOURCES LA English DT Article DE Erigeron lemmonii; Erigeron arisolius; Fleabane; Microsatellites AB We identified eight novel polymorphic microsatellite loci in Erigeron lemmonii and nine novel polymorphic microsatellite loci in Erigeron arisolius. Of these, three loci developed for E. arisolius cross-amplified E. lemmonii DNA and four loci developed for E. lemmonii cross-amplified E. arisolius DNA. This set of 17 loci will be used to analyze patterns of genetic structure in populations of these two Erigeron species in southeastern Arizona with the ultimate goal of comparing patterns of genetic structure within a hyper-rare cliff endemic (E. lemmonii) to those of a more widespread congener (E. arisolius). C1 [Lindsay, Denise L.; Bailey, Pamela; Anderson, Joseph L.; Jung, Michael G.; Edwards, Christine E.; Lance, Richard F.] USA, Environm Lab, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Lindsay, DL (reprint author), USA, Environm Lab, Engineer Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM denise.l.lindsay@usace.army.mil OI Edwards, Christine/0000-0001-8837-4872 NR 5 TC 1 Z9 1 U1 1 U2 9 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 1877-7252 J9 CONSERV GENET RESOUR JI Conserv. Genet. Resour. PD DEC PY 2012 VL 4 IS 4 BP 849 EP 852 DI 10.1007/s12686-012-9657-y PG 4 WC Biodiversity Conservation; Genetics & Heredity SC Biodiversity & Conservation; Genetics & Heredity GA 023IX UT WOS:000310027200007 ER PT J AU Brunye, TT Andonova, E Meneghetti, C Noordzij, ML Pazzaglia, F Wienemann, R Mahoney, CR Taylor, HA AF Brunye, Tad T. Andonova, Elena Meneghetti, Chiara Noordzij, Matthijs L. Pazzaglia, Francesca Wienemann, Rasmus Mahoney, Caroline R. Taylor, Holly A. TI Planning routes around the world: International evidence for southern route preferences SO JOURNAL OF ENVIRONMENTAL PSYCHOLOGY LA English DT Article DE Spatial orientation; Wayfinding; Locomotion; Embodied cognition ID VERTICAL POSITION; MAPS; DISTANCE; INTERSECTIONS; BUILDINGS; SELECTION; COGNITION; DIRECTION; CHOICES AB Three studies test whether the southern route preference, which describes the tendency for route planners to disproportionately select south-rather than north-going routes, can be attributed to regional elevation patterns; specifically, we ask whether this effect replicates in three topographically disparate international regions, one of which is characterized by higher elevations to the north and lower to the south (Padua, Italy), and two characterized by higher elevations to the south and lower to the north (Enschede, Netherlands; Sofia, Bulgaria). In all cases, we found strong evidence that route planners disproportionately select south-rather than north-going routes at rates exceeding chance. We conclude that the southern route preference is driven by strong associations between canonical direction and perceived effort of route traversal; these effects are somewhat perplexing given that such associations are not founded in the reality of physical space. Published by Elsevier Ltd. C1 [Brunye, Tad T.] USA, NSRDEC, Attn RDNS WSH S, Natick, MA 01760 USA. [Brunye, Tad T.; Mahoney, Caroline R.; Taylor, Holly A.] Tufts Univ, Dept Psychol, Medford, MA 02155 USA. [Andonova, Elena] New Bulgarian Univ, Dept Cognit Sci & Psychol, Sofia, Bulgaria. [Meneghetti, Chiara; Pazzaglia, Francesca] Univ Padua, Dept Gen Psychol, Padua, Italy. [Noordzij, Matthijs L.; Wienemann, Rasmus] Univ Twente, Dept Cognit Psychol & Ergon, NL-7500 AE Enschede, Netherlands. [Wienemann, Rasmus] Univ Bremen, D-28359 Bremen, Germany. RP Brunye, TT (reprint author), USA, NSRDEC, Attn RDNS WSH S, 15 Kansas St, Natick, MA 01760 USA. EM thaddeus.brunye@us.army.mil RI Meneghetti, Chiara/D-1691-2014; OI Meneghetti, Chiara/0000-0002-4232-4244; Meneghetti, Chiara/0000-0002-1838-7958; Noordzij, Matthijs/0000-0002-5013-9225 NR 51 TC 5 Z9 5 U1 0 U2 12 PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD PI LONDON PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND SN 0272-4944 J9 J ENVIRON PSYCHOL JI J. Environ. Psychol. PD DEC PY 2012 VL 32 IS 4 BP 297 EP 304 DI 10.1016/j.jenvp.2012.05.003 PG 8 WC Environmental Studies; Psychology, Multidisciplinary SC Environmental Sciences & Ecology; Psychology GA 022VE UT WOS:000309991100002 ER PT J AU Zhou, J Guo, JS Chu, D Chen, RR AF Zhou, Jie Guo, Junsong Chu, Deryn Chen, Rongrong TI Impacts of anion-exchange-membranes with various ionic exchange capacities on the performance of H-2/O-2 fuel cells SO JOURNAL OF POWER SOURCES LA English DT Article DE Anion-exchanged membrane; Block copolymers; Quaternary ammonium; AEM fuel cells; Electrochemical impedance spectra ID OXYGEN REDUCTION REACTION; ALKALINE POLYMER ELECTROLYTE; AC-IMPEDANCE; ELECTROCHEMICAL IMPEDANCE; TEMPERATURE-RANGE; CONDUCTIVITY; CATALYSTS; SYSTEM; POLY(ETHER-IMIDE); ELECTROOXIDATION AB Anion-exchange membranes (AEMs) with varying amounts of quaternary ammonium groups (0.51, 0.70, and 0.90 mmol g(-1)) grafted onto a styrene-ethylene/butylene-styrene (SEBS) block copolymer were prepared and studied for their impact on the performance of solid electrolyte H-2/O-2 fuel cells. A higher content of quaternary ammonium groups in the membranes resulted in higher ionic conductivity and lower OH- transport activation energy in the membranes, which in turn resulted in lower cell overpotentials and higher power density in the performance of the AEM fuel cells. By increasing the quaternary ammonium group from 0.51 to 0.90 mmol g(-1) in the AEMs, the power density of the AEM fuel cells at 50 degrees C was found to increase from 169 to 285 mW cm(-2). For comparison, the performance of AEM fuel cells using a commercial Tokuyamma A901 AEM was also tested. Electrochemical impedance spectra (EIS) recorded during the operation of the AEM fuel cells revealed that the transportation resistance of the OH- ions from the cathode to the anode through the AEM depended on the nature of the AEM and the cell voltage and is a critical factor to consider for improving the performance of AEM fuel cells. (C) 2012 Elsevier B.V. All rights reserved. C1 [Zhou, Jie; Guo, Junsong; Chen, Rongrong] Indiana Univ Purdue Univ, Richard G Lugar Ctr Renewable Energy, Indianapolis, IN 46202 USA. [Chu, Deryn] USA, Res Lab, Adelphi, MD 20783 USA. RP Chen, RR (reprint author), Indiana Univ Purdue Univ, Richard G Lugar Ctr Renewable Energy, Indianapolis, IN 46202 USA. EM rochen@iupui.edu FU Army Research Laboratory [W911NF-10-2-0075] FX This work was sponsored by the Army Research Laboratory (Grant no. W911NF-10-2-0075). The Kraton G SEBS A1535 H sample was kindly provided by Kraton Performance Polymers, Inc. NR 40 TC 13 Z9 13 U1 7 U2 86 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0378-7753 EI 1873-2755 J9 J POWER SOURCES JI J. Power Sources PD DEC 1 PY 2012 VL 219 BP 272 EP 279 DI 10.1016/j.jpowsour.2012.07.051 PG 8 WC Chemistry, Physical; Electrochemistry; Energy & Fuels; Materials Science, Multidisciplinary SC Chemistry; Electrochemistry; Energy & Fuels; Materials Science GA 017CT UT WOS:000309568400039 ER PT J AU Norton, P AF Norton, P. TI Understanding the NE Delta T of tactical infrared focal plane arrays (vol 20, pg 275, 2012) SO OPTO-ELECTRONICS REVIEW LA English DT Correction C1 USA, Night Vis & Elect Sensors Directorate, Ft Belvoir, VA 22060 USA. RP Norton, P (reprint author), USA, Night Vis & Elect Sensors Directorate, Ft Belvoir, VA 22060 USA. NR 1 TC 0 Z9 0 U1 0 U2 1 PU VERSITA PI WARSAW PA SOLIPSKA 14A-1, 02-482 WARSAW, POLAND SN 1230-3402 J9 OPTO-ELECTRON REV JI Opto-Electron. Rev. PD DEC PY 2012 VL 20 IS 4 BP 380 EP 380 DI 10.2478/s11772-012-0050-x PG 1 WC Engineering, Electrical & Electronic; Optics; Physics, Applied SC Engineering; Optics; Physics GA 019BE UT WOS:000309711100011 ER PT J AU Ni, JE Case, ED Sakamoto, JS Rangasamy, E Wolfenstine, JB AF Ni, Jennifer E. Case, Eldon D. Sakamoto, Jeffrey S. Rangasamy, Ezhiyl Wolfenstine, Jeffrey B. TI Room temperature elastic moduli and Vickers hardness of hot-pressed LLZO cubic garnet SO JOURNAL OF MATERIALS SCIENCE LA English DT Article ID RESONANT ULTRASOUND SPECTROSCOPY; YTTRIUM IRON-GARNET; MECHANICAL-PROPERTIES; SINGLE-CRYSTAL; YOUNGS MODULUS; THERMOELECTRIC-MATERIALS; LEAD TELLURIDE; POISSONS RATIO; SHEAR MODULUS; CONSTANTS AB Cubic garnet Li6.24La3Zr2Al0.24O11.98 (LLZO) is a candidate material for use as an electrolyte in Li-Air and Li-S batteries. The use of LLZO in practical devices will require LLZO to have good mechanical integrity in terms of scratch resistance (hardness) and an adequate stiffness (elastic modulus). In this paper, the powders were fabricated by powder processing of cast ingots. All specimens were then densified via hot pressing. The room temperature elastic moduli (Young's modulus, shear modulus, bulk modulus, and Poisson's ratio) and hardness were measured by resonant ultrasound spectroscopy, and Vickers indentation, respectively. For volume fraction porosity, P, the Young's modulus was 149.8 +/- A 0.4 GPa (P = 0.03) and 132.6 +/- A 0.2 GPa (P = 0.06). The mean Vickers hardness was 6.3 +/- A 0.3 GPa for P = 0.03 and 5.2 +/- A 0.4 for P = 0.06. C1 [Ni, Jennifer E.; Case, Eldon D.; Sakamoto, Jeffrey S.; Rangasamy, Ezhiyl] Michigan State Univ, Chem Engn & Mat Sci Dept, E Lansing, MI 48824 USA. [Wolfenstine, Jeffrey B.] USA, Res Lab, RDRL SED C, Adelphi, MD 20783 USA. RP Case, ED (reprint author), Michigan State Univ, Chem Engn & Mat Sci Dept, Room 2527,Engn Bldg, E Lansing, MI 48824 USA. EM casee@egr.msu.edu RI Rangasamy, Ezhiylmurugan/K-8340-2013 FU U.S. Army Research Office (ARO); Army Research Laboratory (ARL) [W911NF-10-2-0089-P00001] FX We would like to acknowledge the financial support of the U.S. Army Research Office (ARO) and the Army Research Laboratory (ARL) under grant W911NF-10-2-0089-P00001. NR 62 TC 27 Z9 27 U1 15 U2 130 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0022-2461 J9 J MATER SCI JI J. Mater. Sci. PD DEC PY 2012 VL 47 IS 23 BP 7978 EP 7985 DI 10.1007/s10853-012-6687-5 PG 8 WC Materials Science, Multidisciplinary SC Materials Science GA 005BX UT WOS:000308726500003 ER PT J AU Hollingshad, NW Turalska, M Allegrini, P West, BJ Grigolini, P AF Hollingshad, Nicholas W. Turalska, Malgorzata Allegrini, Paolo West, Bruce J. Grigolini, Paolo TI A new measure of network efficiency (vol 391, pg 1894, 2012) SO PHYSICA A-STATISTICAL MECHANICS AND ITS APPLICATIONS LA English DT Correction C1 [Hollingshad, Nicholas W.] Univ N Texas, Ctr Nonlinear Sci, Denton, TX 76203 USA. Ist Fisiol Clin IFC CNR, I-56124 Pisa, Italy. USA, Informat Sci Directorate, Res Off, Durham, NC 27709 USA. RP Hollingshad, NW (reprint author), Univ N Texas, Ctr Nonlinear Sci, POB 311427, Denton, TX 76203 USA. EM nwh0012@unt.edu RI Allegrini, Paolo/C-1876-2012 OI Allegrini, Paolo/0000-0002-5476-9005 NR 1 TC 0 Z9 0 U1 0 U2 4 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0378-4371 J9 PHYSICA A JI Physica A PD DEC 1 PY 2012 VL 391 IS 23 BP 6246 EP 6246 DI 10.1016/j.physa.2012.07.035 PG 1 WC Physics, Multidisciplinary SC Physics GA 005YD UT WOS:000308785100049 ER PT J AU Aguilar, C Zinnert, JC Polo, MJ Young, DR AF Aguilar, Cristina Zinnert, Julie C. Jose Polo, Maria Young, Donald R. TI NDVI as an indicator for changes in water availability to woody vegetation SO ECOLOGICAL INDICATORS LA English DT Article DE NDVI; Precipitation; Freshwater lens; Water table depth; Plant stress; Airborne; Landsat TM ID CENTRAL GREAT-PLAINS; BARRIER-ISLAND; PATAGONIAN STEPPE; DYNAMICS; DROUGHT; REFLECTANCE; RESPONSES; INDEXES; PRECIPITATION; TEMPERATURE AB Barrier islands shrub thickets, the dominant woody community of many Atlantic coast barrier islands, are very sensitive to changes in the freshwater lens and thus, constitute a strong indicator of summer drought. NDVI was computed from airborne images and multispectral images on Hog Island (VA, USA) to evaluate summer growing season changes in woody communities for better predictions of climate change effects. Patterns of NDVI were compared year to year and monthly relative to precipitation and water table depth at the appropriate temporal scale. The highest absolute values of NDVI as well as the larger surface covered by woody vegetation (NDVI > 0.5) occurred in the wet year (2004) with a bimodal distribution of NDVI values (around 0.65 and 0.9) while both dry years (2007 and 2008) showed similar values in maximum, mean and standard deviation and unimodal distributions (around 0.75) of NDVI values. Positive linear adjustments were obtained between maximum (r(2) > 0.9) and mean NDVI (r(2) > 0,87) and the accumulated rainfall in the hydrological year and the mean water table depth from the last rainfall event till the date of the image acquisition. The spatial variations revealed that water table depth behaved different in wet and dry years. In dry years there was a remarkable increase in mean and maximum values linearly related to water table depth. The highest slope of the adjustment in 2007 indicated a sharp response of vegetation in the driest year. Monthly series of NDVI showed the major role of lack of precipitation through July and August in 2007 with missing classes of NDVI above 0.8 and unimodal distributions in mid-late summer. Best linear fits (r(2) close to 1) were obtained with rainfall at different temporal scales: accumulated rainfall in the hydrological year 2004 and accumulated rainfall in the last month previous to the date of 2007 image. Thus, in dry years productivity is closely related to water available from recent past as opposed to over the year for wet years. Good fits (r(2) values higher than 0.88) were obtained between monthly decrease in water table depth and NDVI variables just in the dry year. These results demonstrate the important feedback between woody vegetation response to changes in the freshwater lens using empirical data and could apply to other systems with strong directional gradients in resources. (c) 2012 Elsevier Ltd. All rights reserved. C1 [Aguilar, Cristina; Jose Polo, Maria] IISTA Univ Cordoba, Fluvial Dynam & Hydrol Res Grp, Cordoba 14071, Spain. [Zinnert, Julie C.] USA, ERDC, Fluorescence Spect Lab, Alexandria, VA 22315 USA. [Zinnert, Julie C.; Young, Donald R.] Virginia Commonwealth Univ, Dept Biol, Richmond, VA 23284 USA. RP Aguilar, C (reprint author), IISTA Univ Cordoba, Fluvial Dynam & Hydrol Res Grp, Rabanales Campus,Leonardo Da Vinci Bldg, Cordoba 14071, Spain. EM caguilar@uco.es RI Polo, Maria J./L-8018-2014; Aguilar, Cristina/E-6167-2017 OI Polo, Maria J./0000-0002-6296-2198; Aguilar, Cristina/0000-0002-9418-1679 FU National Science Foundation [BSR-8702333-06, DEB-9211772, DEB-9411974, DEB-0080381, DEB-0621014] FX Some data used in this publication was provided by the Virginia Coast Reserve LTER project, which was supported by National Science Foundation grants BSR-8702333-06, DEB-9211772, DEB-9411974, DEB-0080381 and DEB-0621014. The authors would like to thank the people involved in AERONET and USGS-Earth Explorer teams for providing atmospheric and remote sensing data used for this study. NR 44 TC 23 Z9 25 U1 2 U2 36 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1470-160X J9 ECOL INDIC JI Ecol. Indic. PD DEC PY 2012 VL 23 BP 290 EP 300 DI 10.1016/j.ecolind.2012.04.008 PG 11 WC Biodiversity Conservation; Environmental Sciences SC Biodiversity & Conservation; Environmental Sciences & Ecology GA 983PD UT WOS:000307130300032 ER PT J AU Cercy, SP Marasia, JC AF Cercy, Steven P. Marasia, Joseph C. TI Combined Delusional Misidentification Syndrome in a Patient With Parkinson's Disease SO JOURNAL OF NEUROPSYCHIATRY AND CLINICAL NEUROSCIENCES LA English DT Letter C1 [Cercy, Steven P.] VA New York Harbor Healthcare Syst, Mental Hlth Serv, New York, NY USA. [Cercy, Steven P.] NYU, Sch Med, Dept Psychiat, New York, NY USA. [Marasia, Joseph C.] Keller Army Community Hosp, West Point, NY USA. RP Cercy, SP (reprint author), VA New York Harbor Healthcare Syst, Mental Hlth Serv, New York, NY USA. EM steven.cercy@va.gov OI Cercy, Steven/0000-0002-8485-6003 NR 5 TC 6 Z9 6 U1 0 U2 0 PU AMER PSYCHIATRIC PUBLISHING, INC PI ARLINGTON PA 1000 WILSON BOULEVARD, STE 1825, ARLINGTON, VA 22209-3901 USA SN 0895-0172 J9 J NEUROPSYCH CLIN N JI J. Neuropsychiatr. Clin. Neurosci. PD WIN PY 2012 VL 24 IS 1 BP E3 EP E4 PG 2 WC Clinical Neurology; Neurosciences; Psychiatry SC Neurosciences & Neurology; Psychiatry GA 925AD UT WOS:000302731500002 PM 22450637 ER PT J AU Fischer, RA Valente, JJ Guilfoyle, MP Kaller, MD Jackson, SS AF Fischer, Richard A. Valente, Jonathon J. Guilfoyle, Michael P. Kaller, Michael D. Jackson, Sam S. TI Bird Community Response to Vegetation Cover and Composition in Riparian Habitats Dominated by Russian Olive (Elaeagnus angustifolia) SO NORTHWEST SCIENCE LA English DT Article ID MIDDLE RIO-GRANDE; NORTH-AMERICA; UNITED-STATES; NEW-MEXICO; RIVER; TAMARIX; ASSOCIATIONS; PHYSIOGNOMY; MANAGEMENT; FLORISTICS AB Riparian systems in the western United States provide important habitat for bird communities during all times of the year. In recent decades, invasive plants, such as Russian olive (Elaeagnus angustifolia), have achieved broad distribution and local dominance in many western riparian areas, raising concerns over the loss of ecological function within these systems. In 2005 and 2006 we conducted avian point counts and surveyed vegetation cover at 95 points along the Snake and Columbia Rivers in southeastern Washington to investigate the effects of total woody vegetation cover and the relative proportion of Russian olive cover on breeding and wintering riparian bird communities. Our results indicated that riparian habitats dominated by Russian olive can support diverse and abundant bird communities, though cavity nesting species were noticeably sparse. Bird density and species richness were best explained by a quadratic relationship to total woody vegetation cover in both seasons, as was breeding bird community composition, with greatest density and richness in intermediate cover levels. We found no indication that the proportion of the woody vegetation comprised of Russian olive strongly influenced any of these bird community metrics. Given that Russian olive comprised 81.6% of the riparian vegetation in our study area, it is unclear from our results how Russian olive would affect bird communities in regions where native vegetation is more abundant. Regardless, complete eradication of Russian olive from riparian systems where the plant is a major component will reduce the overall habitat value for birds by eliminating significant structural complexity. C1 [Fischer, Richard A.; Valente, Jonathon J.; Guilfoyle, Michael P.; Jackson, Sam S.] USA, Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA. [Kaller, Michael D.] Louisiana State Univ, Ctr Agr, Sch Renewable Nat Resources, Baton Rouge, LA 70803 USA. RP Valente, JJ (reprint author), USA, Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA. EM Jonathon.J.Valente@gmail.com FU U.S. Army Engineer District Walla Walla FX The authors are grateful to J. Horne, N. Nielsen-Pincus, E. Ellsworth, R. Melcer, J. Trochet, P. Gibert, E. Lindgren, and O. Alminas, M. Wickens, and N. Holcomb for assistance with seasonal surveys; and B. Vessels, G. Thornberry, and J. VanHoff for providing mapping support for GIS work and data entry and summary. Special thanks to M. Halupczok and K. Carpenter for extensive logistical assistance and to M. Ford, C. Martin, and three anonymous reviewers for providing manuscript reviews. Support for this study was provided by the U.S. Army Engineer District Walla Walla. Permission was granted by the Chief of Engineers to publish this material. NR 40 TC 4 Z9 4 U1 4 U2 64 PU NORTHWEST SCIENTIFIC ASSOC PI SEATTLE PA JEFFREY DUDA, USGS, WESTERN FISHERIES RES CTR, 6505 NE 65 ST, SEATTLE, WA 98115 USA SN 0029-344X J9 NORTHWEST SCI JI Northwest Sci. PD WIN PY 2012 VL 86 IS 1 BP 39 EP 52 PG 14 WC Ecology SC Environmental Sciences & Ecology GA 905LG UT WOS:000301273100004 ER PT J AU Kaczynski, WH Leemis, LM Drew, JH AF Kaczynski, William H. Leemis, Lawrence M. Drew, John H. TI Transient Queueing Analysis SO INFORMS JOURNAL ON COMPUTING LA English DT Article DE exponential distribution; Poisson process; queueing theory ID STEADY-STATE SIMULATION; M/M/1 QUEUE; BEHAVIOR; SYSTEMS AB The exact distribution of the nth customer's sojourn time in an M/M/s queue with k customers initially present is derived. Algorithms for computing the covariance between sojourn times for an M/M/1 queue with k customers present at time 0 are also developed. Maple computer code is developed for practical application of transient queue analysis for many system measures of performance without regard to traffic intensity (i.e., the system may be unstable with traffic intensity greater than 1). C1 [Kaczynski, William H.] US Mil Acad, Dept Math Sci, West Point, NY 10996 USA. [Leemis, Lawrence M.; Drew, John H.] Coll William & Mary, Dept Math, Williamsburg, VA 23187 USA. RP Kaczynski, WH (reprint author), US Mil Acad, Dept Math Sci, West Point, NY 10996 USA. EM william.kaczynski@usma.edu; leemis@math.wm.edu; jhdrew@math.wm.edu NR 21 TC 7 Z9 7 U1 1 U2 4 PU INFORMS PI HANOVER PA 7240 PARKWAY DR, STE 310, HANOVER, MD 21076-1344 USA SN 1091-9856 J9 INFORMS J COMPUT JI INFORMS J. Comput. PD WIN PY 2012 VL 24 IS 1 BP 10 EP 28 DI 10.1287/ijoc.1110.0452 PG 19 WC Computer Science, Interdisciplinary Applications; Operations Research & Management Science SC Computer Science; Operations Research & Management Science GA 899UV UT WOS:000300842900002 ER PT J AU Covell, DG Wallqvist, A Kenney, S Vistica, DT AF Covell, David G. Wallqvist, Anders Kenney, Susan Vistica, David T. TI Bioinformatic Analysis of Patient-Derived ASPS Gene Expressions and ASPL-TFE3 Fusion Transcript Levels Identify Potential Therapeutic Targets SO PLOS ONE LA English DT Article ID SOFT-PART SARCOMA; GROWTH-FACTOR; AUTOCRINE GROWTH; CONNECTIVITY MAP; CHEMOKINE; TUMORS; RHABDOMYOSARCOMA; INHIBITION; SIGNATURES; CANCER AB Gene expression data, collected from ASPS tumors of seven different patients and from one immortalized ASPS cell line (ASPS-1), was analyzed jointly with patient ASPL-TFE3 (t(X;17)(p11;q25)) fusion transcript data to identify disease-specific pathways and their component genes. Data analysis of the pooled patient and ASPS-1 gene expression data, using conventional clustering methods, revealed a relatively small set of pathways and genes characterizing the biology of ASPS. These results could be largely recapitulated using only the gene expression data collected from patient tumor samples. The concordance between expression measures derived from ASPS-1 and both pooled and individual patient tumor data provided a rationale for extending the analysis to include patient ASPL-TFE3 fusion transcript data. A novel linear model was exploited to link gene expressions to fusion transcript data and used to identify a small set of ASPS-specific pathways and their gene expression. Cellular pathways that appear aberrantly regulated in response to the t(X; 17)(p11; q25) translocation include the cell cycle and cell adhesion. The identification of pathways and gene subsets characteristic of ASPS support current therapeutic strategies that target the FLT1 and MET, while also proposing additional targeting of genes found in pathways involved in the cell cycle (CHK1), cell adhesion (ARHGD1A), cell division (CDC6), control of meiosis (RAD51L3) and mitosis (BIRC5), and chemokine-related protein tyrosine kinase activity (CCL4). C1 [Covell, David G.; Kenney, Susan; Vistica, David T.] NCI, Dev Therapeut Program, Frederick Natl Lab Canc Res, Frederick, MD 21701 USA. [Wallqvist, Anders] USA, Med Res & Mat Command, Dept Def Biotechnol,Telemed & Adv Technol Res Ctr, High Performance Comp Software Applicat Inst, Ft Detrick, MD USA. RP Covell, DG (reprint author), NCI, Dev Therapeut Program, Frederick Natl Lab Canc Res, Frederick, MD 21701 USA. EM covelld@mail.nih.gov OI wallqvist, anders/0000-0002-9775-7469 NR 48 TC 7 Z9 9 U1 0 U2 1 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD NOV 30 PY 2012 VL 7 IS 11 AR e48023 DI 10.1371/journal.pone.0048023 PG 16 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 054WM UT WOS:000312376100010 PM 23226201 ER PT J AU Knorr, DB Yu, JH Richardson, AD Hindenlang, MD McAninch, IM La Scala, JJ Lenhart, JL AF Knorr, Daniel B., Jr. Yu, Jian H. Richardson, Adam D. Hindenlang, Mark D. McAninch, Ian M. La Scala, John J. Lenhart, Joseph L. TI Glass transition dependence of ultrahigh strain rate response in amine cured epoxy resins SO POLYMER LA English DT Article DE High strain rate; Epoxy-amine; Glass transition ID ENERGY-ABSORPTION; MECHANICAL-BEHAVIOR; BALLISTIC PERFORATION; PLASTIC-DEFORMATION; MOLECULAR ANALYSIS; PART I; COMPOSITES; IMPACT; POLYMERS; FRACTURE AB Ultrahigh strain rate performance in a series of model amine cured epoxy resins was investigated as a function of the glass transition temperature (T-g) of the cured polymer network, where the network T-g was systematically varied through the monomer stiffness, structure, and size. The high rate response was characterized in terms of a projectile penetration velocity, V50BL(P) (ballistic limit, protection criteria), which describes the projectile velocity with a 50% probability of sample penetration. One factor that dictates the ballistic performance of the epoxy networks, at effective rates of 10(4)-10(5) s(-1), is the difference between the measurement temperature and the glass transition temperature of the network. Sub-T-g relaxations did not have a measurable effect on ballistic performance, and neither did the monomer structure and functionality outside of the influence of the resin T-g, while off-stoichiometric (excess amine) formulations improved V50BL(P) slightly with high T-g epoxies. The results have implications in protective materials for military, aerospace, transportation, and construction industries, where high strain rate insults from airborne debris, high rate collisions, and natural events are increasingly considered during product design. Published by Elsevier Ltd. C1 [Knorr, Daniel B., Jr.; Yu, Jian H.; Richardson, Adam D.; Hindenlang, Mark D.; McAninch, Ian M.; La Scala, John J.; Lenhart, Joseph L.] USA, Res Lab, Aberdeen Proving Ground, MD 21009 USA. RP Lenhart, JL (reprint author), USA, Res Lab, 4600 Deer Creek Loop, Aberdeen Proving Ground, MD 21005 USA. EM joseph.l.lenhart.civ@mail.mil OI McAninch, Ian/0000-0002-9190-2936 NR 54 TC 15 Z9 15 U1 1 U2 44 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0032-3861 J9 POLYMER JI Polymer PD NOV 30 PY 2012 VL 53 IS 25 BP 5917 EP 5923 DI 10.1016/j.polymer.2012.09.058 PG 7 WC Polymer Science SC Polymer Science GA 047DW UT WOS:000311818900034 ER PT J AU Reed, MW Walker, PM Cullen, IJ Litvinov, YA Shubina, D Dracoulis, GD Blaum, K Bosch, F Brandau, C Carroll, JJ Cullen, DM Deo, AY Detwiler, B Dimopoulou, C Dong, GX Farinon, F Geissel, H Haettner, E Heil, M Kempley, RS Knobel, R Kozhuharov, C Kurcewicz, J Kuzminchuk, N Litvinov, S Liu, Z Mao, R Nociforo, C Nolden, F Plass, WR Podolyak, Z Prochazka, A Scheidenberger, C Steck, M Stohlker, T Sun, B Swan, TPD Trees, G Weick, H Winckler, N Winkler, M Woods, PJ Xu, FR Yamaguchi, T AF Reed, M. W. Walker, P. M. Cullen, I. J. Litvinov, Yu. A. Shubina, D. Dracoulis, G. D. Blaum, K. Bosch, F. Brandau, C. Carroll, J. J. Cullen, D. M. Deo, A. Y. Detwiler, B. Dimopoulou, C. Dong, G. X. Farinon, F. Geissel, H. Haettner, E. Heil, M. Kempley, R. S. Knoebel, R. Kozhuharov, C. Kurcewicz, J. Kuzminchuk, N. Litvinov, S. Liu, Z. Mao, R. Nociforo, C. Nolden, F. Plass, W. R. Podolyak, Zs. Prochazka, A. Scheidenberger, C. Steck, M. Stoehlker, Th. Sun, B. Swan, T. P. D. Trees, G. Weick, H. Winckler, N. Winkler, M. Woods, P. J. Xu, F. R. Yamaguchi, T. TI Long-lived isomers in neutron-rich Z=72-76 nuclides SO PHYSICAL REVIEW C LA English DT Article ID SCHOTTKY MASS-SPECTROMETRY; STORAGE-RING ESR; QUASI-PARTICLE STATES; HEAVY-ION STORAGE; PROJECTILE FRAGMENTS; EXOTIC NUCLEI; ATOMIC-NUCLEI; K-ISOMERS; DECAY; ISOTOPES AB A study of neutron-rich isotopes in the A = 185 region of the nuclear chart has uncovered long-lived (>1 s) isomers in several isotopes of hafnium, tantalum, tungsten, rhenium, and osmium. The region was accessed via the use of projectile fragmentation with the UNILAC-SIS accelerators at GSI. Fragmentation products of Au-197 were passed through the fragment separator (FRS) and injected into the experimental storage ring (ESR), where single-ion identifications could be made. Evidence is presented for isomers in Hf-183,Hf-184,Hf-186, Ta-186,Ta-187, W-186, Re-190,Re-192,Re-194, and Os-195 with excitation energies in the range of 0.1-3.0 MeV. The lightest of these nuclides have well deformed prolate shapes, while the heaviest are transitional and susceptible to shape changes. Their properties are interpreted with the help of multi-quasiparticle and potential-energy-surface calculations. C1 [Reed, M. W.; Walker, P. M.; Cullen, I. J.; Deo, A. Y.; Kempley, R. S.; Podolyak, Zs.; Swan, T. P. D.] Univ Surrey, Dept Phys, Guildford GU2 7XH, Surrey, England. [Reed, M. W.; Dracoulis, G. D.] Australian Natl Univ, RSPE, Dept Nucl Phys, Canberra, ACT 0200, Australia. [Walker, P. M.] CERN, CH-1211 Geneva 23, Switzerland. [Shubina, D.; Blaum, K.; Winckler, N.] Max Planck Inst Kernphys, D-69117 Heidelberg, Germany. [Brandau, C.] GSI Helmholtzzentrum Schwerionenforsch, ExtreMe Matter Inst EMMI, D-64291 Darmstadt, Germany. [Brandau, C.] GSI Helmholtzzentrum Schwerionenforsch, Div Res, D-64291 Darmstadt, Germany. [Brandau, C.] Inst Atom & Mol Phys, D-35392 Giessen, Germany. [Carroll, J. J.] USA, Res Lab, Adelphi, MD USA. [Cullen, D. M.] Univ Manchester, Schuster Lab, Manchester M13 9PL, Lancs, England. [Detwiler, B.] Youngstown State Univ, Youngstown, OH 44555 USA. [Dong, G. X.; Xu, F. R.] Peking Univ, Dept Tech Phys, Beijing 100871, Peoples R China. [Geissel, H.; Haettner, E.; Plass, W. R.; Scheidenberger, C.] Univ Giessen, Inst Phys 2, D-35392 Giessen, Germany. [Liu, Z.; Woods, P. J.] Univ Edinburgh, Sch Phys & Astron, Edinburgh EH9 3JZ, Midlothian, Scotland. [Mao, R.] Chinese Acad Sci, Inst Modern Phys, Lanzhou 730000, Peoples R China. [Stoehlker, Th.] Heidelberg Univ, Inst Phys, D-69120 Heidelberg, Germany. [Sun, B.] Beihaug Univ, Sch Phys & Nucl Energy Engn, Beijing 100191, Peoples R China. [Yamaguchi, T.] Saitama Univ, Grad Sch Sci & Engn, Saitama 3388570, Japan. RP Reed, MW (reprint author), Univ Surrey, Dept Phys, Guildford GU2 7XH, Surrey, England. EM matthew.reed@anu.edu.au RI Xu, Furong/K-4178-2013; Sun, Baohua/C-6823-2009 OI Sun, Baohua/0000-0001-9868-5711 FU UK STFC; AWE plc; DTRA (YSU); Australian Research Council; BMBF [06GI 911I, FKZ 01DO12012]; Helmholtz Alliance [HA216/EMMI]; international Max Planck Research School for Precision Test of Fundamental Symmetries at MPIK; NECT; NSFC [11105010]; Japanese Ministry of Education, Science and Culture [A19204023] FX The authors are grateful to the accelerator team for their excellent contribution. This work has been supported by the UK STFC, AWE plc, DTRA (YSU), and the Australian Research Council. C. B. was supported by BMBF (Contract No. 06GI 911I) and by the Helmholtz Alliance HA216/EMMI. D. S. is supported by the international Max Planck Research School for Precision Test of Fundamental Symmetries at MPIK. B. S. is partially supported by NECT and NSFC 11105010 and by the BMBF Grant in the framework of the Internationale Zusammenarbeit in Bildung und Forschung, No. FKZ 01DO12012. T. Y. is grateful for a grant-in-aid for scientific research No. A19204023 by the Japanese Ministry of Education, Science and Culture. NR 75 TC 26 Z9 26 U1 1 U2 19 PU AMER PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 2469-9985 EI 2469-9993 J9 PHYS REV C JI Phys. Rev. C PD NOV 29 PY 2012 VL 86 IS 5 AR 054321 DI 10.1103/PhysRevC.86.054321 PG 14 WC Physics, Nuclear SC Physics GA 045KL UT WOS:000311694600002 ER PT J AU Kugelman, JR Lee, MS Rossi, CA McCarthy, SE Radoshitzky, SR Dye, JM Hensley, LE Honko, A Kuhn, JH Jahrling, PB Warren, TK Whitehouse, CA Bavari, S Palacios, G AF Kugelman, Jeffrey R. Lee, Michael S. Rossi, Cynthia A. McCarthy, Sarah E. Radoshitzky, Sheli R. Dye, John M. Hensley, Lisa E. Honko, Anna Kuhn, Jens H. Jahrling, Peter B. Warren, Travis K. Whitehouse, Chris A. Bavari, Sina Palacios, Gustavo TI Ebola Virus Genome Plasticity as a Marker of Its Passaging History: A Comparison of In Vitro Passaging to Non-Human Primate Infection SO PLOS ONE LA English DT Article ID VIRION GLYCOPROTEINS; HEMORRHAGIC-FEVER; ZAIRE EBOLAVIRUS; RNA; RECEPTOR AB To identify polymorphic sites that could be used as biomarkers of Ebola virus passage history, we repeatedly amplified Ebola virus (Kikwit variant) in vitro and in vivo and performed deep sequencing analysis of the complete genomes of the viral subpopulations. We then determined the sites undergoing selection during passage in Vero E6 cells. Four locations within the Ebola virus Kikwit genome were identified that together segregate cell culture-passaged virus and virus obtained from infected non-human primates. Three of the identified sites are located within the glycoprotein gene (GP) sequence: the poly-U (RNA editing) site at position 6925, as well as positions 6677, and 6179. One site was found in the VP24 gene at position 10833. In all cases, in vitro and in vivo, both populations (majority and minority variants) were maintained in the viral swarm, with rapid selections occurring after a few passages or infections. This analysis approach will be useful to differentiate whether filovirus stocks with unknown history have been passaged in cell culture and may support filovirus stock standardization for medical countermeasure development. C1 [Kugelman, Jeffrey R.; Lee, Michael S.; McCarthy, Sarah E.; Whitehouse, Chris A.; Palacios, Gustavo] USAMRIID, Genom Div, Ft Detrick, MD USA. [Dye, John M.; Hensley, Lisa E.; Honko, Anna] USAMRIID, Div Virol, Ft Detrick, MD USA. [Radoshitzky, Sheli R.; Warren, Travis K.; Bavari, Sina] USAMRIID, Div Toxicol, Ft Detrick, MD USA. [Rossi, Cynthia A.] USAMRIID, Diagnost Syst Div, Ft Detrick, MD USA. [Kuhn, Jens H.; Jahrling, Peter B.] NIAID, Integrated Res Facil Ft Detrick, NIH, Ft Detrick, MD USA. [Lee, Michael S.] USA, Simulat Sci Branch, Res Lab, Aberdeen Proving Ground, MD USA. RP Palacios, G (reprint author), USAMRIID, Genom Div, Ft Detrick, MD USA. EM gustavo.f.palacios.ctr@us.army.mil RI Kuhn, Jens H./B-7615-2011; Palacios, Gustavo/I-7773-2015 OI Honko, Anna/0000-0001-9165-148X; Kuhn, Jens H./0000-0002-7800-6045; Palacios, Gustavo/0000-0001-5062-1938 FU NIAID [HHSN272200200016I] FX Opinions, interpretations, conclusions, and recommendations are those of the authors and are not necessarily endorsed by the U.S. Army. JHK performed this work as an employee of Tunnell Consulting, Inc., a subcontractor to Battelle Memorial Institute under its prime contract with NIAID, under Contract No. HHSN272200200016I. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 24 TC 25 Z9 25 U1 1 U2 20 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD NOV 28 PY 2012 VL 7 IS 11 AR e50316 DI 10.1371/journal.pone.0050316 PG 7 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 057YW UT WOS:000312601700056 PM 23209706 ER PT J AU Chantawansri, TL Sirk, TW Byrd, EFC Andzelm, JW Rice, BM AF Chantawansri, Tanya L. Sirk, Timothy W. Byrd, Edward F. C. Andzelm, Jan W. Rice, Betsy M. TI Shock Hugoniot calculations of polymers using quantum mechanics and molecular dynamics SO JOURNAL OF CHEMICAL PHYSICS LA English DT Article ID DENSITY-FUNCTIONAL-THEORY; DER-WAALS INTERACTIONS; COMPASS FORCE-FIELD; GENERALIZED GRADIENT APPROXIMATION; NONCOVALENT INTERACTIONS; SIMULATIONS; DETONATION; COMPLEXES; PARAMETERIZATION; HYDROCARBONS AB Using quantum mechanics (QM) and classical force-field based molecular dynamics (FF), we have calculated the principle shock Hugoniot curves for numerous amorphous polymers including poly[methyl methacrylate] (PMMA), poly[styrene], polycarbonate, as well as both the amorphous and crystalline forms of poly[ethylene]. In the FF calculations, we considered a non-reactive force field (i.e., polymer consistent FF). The QM calculations were performed with density functional theory (DFT) using dispersion corrected atom centered pseudopotentials. Overall, results obtained by DFT show much better agreement with available experimental data than classical force fields. In particular, DFT calculated Hugoniot curves for PMMA up to 74 GPa are in very good agreement with experimental data, where a preliminary study of chain fracture and association was also performed. Structure analysis calculations of the radius of gyration and carbon-carbon radial distribution function were also carried out to elucidate contraction of the polymer chains with increasing pressure. [http://dx.doi.org/10.1063/1.4767394] C1 [Chantawansri, Tanya L.; Sirk, Timothy W.; Byrd, Edward F. C.; Andzelm, Jan W.; Rice, Betsy M.] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Chantawansri, TL (reprint author), USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RI Chantawansri, Tanya/N-3601-2013 FU U.S. Army Research Laboratory Enterprise for Multi-scale Research of Materials; U.S. Army Research Laboratory; U.S. Department of Energy (DOE) FX This work was funded by the U.S. Army Research Laboratory Enterprise for Multi-scale Research of Materials. Calculations were performed using the DOD Supercomputing Resource Center located at the Air Force Laboratory. Calculations were performed on DOD High Performance Computing site at the AFRL through the Challenge Project C5M. Dr. T. W. Sirk was supported by an appointment to the Postgraduate Research Participation Program at the U.S. Army Research Laboratory administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the U.S. Department of Energy (DOE) and the U.S. Army Research Laboratory. We would like to thank Dr. C. K. Knox for help with LAMMPS scripts and Dr. Y. R. Sliozberg for useful discussion. NR 69 TC 12 Z9 12 U1 4 U2 79 PU AMER INST PHYSICS PI MELVILLE PA 1305 WALT WHITMAN RD, STE 300, MELVILLE, NY 11747-4501 USA SN 0021-9606 EI 1089-7690 J9 J CHEM PHYS JI J. Chem. Phys. PD NOV 28 PY 2012 VL 137 IS 20 AR 204901 DI 10.1063/1.4767394 PG 11 WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical SC Chemistry; Physics GA 053DZ UT WOS:000312252100054 PM 23206025 ER PT J AU Watcharananan, S Gayvee, J Kanthachuvejsiri, S Kitiyakara, C Karnchanapoom, T AF Watcharananan, S. Gayvee, J. Kanthachuvejsiri, S. Kitiyakara, C. Karnchanapoom, T. TI Transmission of Oriental Tsutsugamichi from a Deceased Donor to Three Organ Transplant Recipients in Thailand SO TRANSPLANTATION LA English DT Meeting Abstract C1 [Watcharananan, S.; Kanthachuvejsiri, S.; Kitiyakara, C.] Mahidol Univ, Ramathibodi Hosp, Fac Med, Med, Bangkok, Thailand. [Gayvee, J.] Armed Forces Res Inst Med Sci, Div Res, Bangkok, Thailand. [Karnchanapoom, T.] Vichaiyut Hosp, Bangkok, Thailand. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0041-1337 EI 1534-6080 J9 TRANSPLANTATION JI Transplantation PD NOV 27 PY 2012 VL 94 IS 10 SU S MA 2282 BP 549 EP 549 PG 1 WC Immunology; Surgery; Transplantation SC Immunology; Surgery; Transplantation GA V45WJ UT WOS:000209846402348 ER PT J AU Reisler, RB Gibbs, PH Danner, DK Boudreau, EF AF Reisler, Ronald B. Gibbs, Paul H. Danner, Denise K. Boudreau, Ellen F. TI Immune interference in the setting of same-day administration of two similar inactivated alphavirus vaccines: Eastern equine and western equine encephalitis SO VACCINE LA English DT Article DE Eastern equine encephalitis vaccine; Western equine encephalitis vaccine; Plaque-reduction neutralization test (PRNT) ID YELLOW-FEVER VACCINE; EMBRYO CELL CULTURE; BOOSTER VACCINATION; ANTIBODY-RESPONSE; VIRUS; GENDER; INDIVIDUALS; MEASLES; ADULTS; AGE AB We compared the effect on primary vaccination plaque-reduction neutralization 80% titers (PRNT80) responses of same-day administration (at different injection sites) of two similar investigational inactivated alphavirus vaccines, eastern equine encephalitis (EEE) vaccine (TSI-GSD 104) and western equine encephalitis (WEE) vaccine (TSI-GSD 210) to separate administration. Overall, primary response rate for EEE vaccine was 524/796(66%) and overall primary response rate for WEE vaccine was 291/695 (42%). EEE vaccine same-day administration yielded a 59% response rate and a responder geometric mean titer (GMT)= 89 while separate administration yielded a response rate of 69% and a responder GMT= 119. WEE vaccine same-day administration yielded a 30% response rate and a responder GMT= 53 while separate administration yielded a response rate of 54% and a responder GMT= 79. EEE response rates for same-day administration (group A) vs. non-same-day administration (group B) were significantly affected by gender. A logistic regression model predicting response to EEE comparing group B to group A for females yielded an OR = 4.10(95% CL 1.97-8.55; p = .0002) and for males yielded an OR= 1.25(95% CL 0.76-2.07; p = .3768). WEE response rates for same-day administration vs. non-same-day administration were independent of gender. A logistic regression model predicting response to WEE comparing group B to group A yielded an OR = 2.14(95% CL 1.22-3.73; p = .0077). We report immune interference occurring with same-day administration of two completely separate formalin inactivated viral vaccines in humans. These findings combined with the findings of others regarding immune interference would argue for a renewed emphasis on studying the immunological mechanisms of induction of inactivated viral vaccine protection. (C) 2012 Published by Elsevier Ltd. C1 [Reisler, Ronald B.; Gibbs, Paul H.; Danner, Denise K.; Boudreau, Ellen F.] USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. RP Reisler, RB (reprint author), HHS ASPR BARDA, 375 E St SW,PP2,Room 12-1505, Washington, DC 20024 USA. EM Ronald.Reisler@hhs.gov NR 47 TC 8 Z9 8 U1 0 U2 3 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X J9 VACCINE JI Vaccine PD NOV 26 PY 2012 VL 30 IS 50 BP 7271 EP 7277 DI 10.1016/j.vaccine.2012.09.049 PG 7 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 056XB UT WOS:000312523600027 PM 23031498 ER PT J AU O'Brien, DJ Parquette, B AF O'Brien, Daniel J. Parquette, Brian TI Polymer toughness transfer in a transparent interpenetrating glass-polymer composite SO COMPOSITES SCIENCE AND TECHNOLOGY LA English DT Article DE Nanocomposites; Fracture toughness; Crack; Hardness testing; Interpenetrating network ID INTERLAMINAR FRACTURE-TOUGHNESS; FIBRE/VINYL-ESTER COMPOSITES; PHASE COMPOSITES; MATRIX TOUGHNESS; MECHANICAL-PROPERTIES; LIGHT TRANSMITTANCE; CHEMICAL-STRUCTURE; IMPACT RESISTANCE; MODE-I; INDENTATION AB Nanoporous glass-polymer composites provide a convenient, manufacturable solution for producing transparent composite materials. Such materials may fulfill needs for next-generation, impact- and blast-resistant transparencies in applications such as vehicle windshields and architectural windows. In this work we manufacture transparent composites from a commercially available nanoporous glass by infiltrating the glass with monomer and polymerizing in situ, resulting in an interpenetrating network of glass and polymer. Here, we show that the toughness of the polymer phase plays a significant role in overall composite toughness. Experiments show that, on average, a 100% increase in polymer toughness corresponds to an approximate 40% increase in overall composite toughness. Published by Elsevier Ltd. C1 [O'Brien, Daniel J.; Parquette, Brian] USA, Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. RP O'Brien, DJ (reprint author), USA, Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. EM daniel.j.obrien58.civ@mail.mil NR 48 TC 8 Z9 8 U1 1 U2 29 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0266-3538 J9 COMPOS SCI TECHNOL JI Compos. Sci. Technol. PD NOV 23 PY 2012 VL 73 BP 57 EP 63 DI 10.1016/j.compscitech.2012.09.007 PG 7 WC Materials Science, Composites SC Materials Science GA 044CN UT WOS:000311597100009 ER PT J AU Knorr, DB Benight, SJ Krajina, B Zhang, C Dalton, LR Overney, RM AF Knorr, Daniel B., Jr. Benight, Stephanie J. Krajina, Brad Zhang, Cheng Dalton, Larry R. Overney, Rene M. TI Nanoscale Phase Analysis of Molecular Cooperativity and Thermal Transitions in Dendritic Nonlinear Optical Glasses SO JOURNAL OF PHYSICAL CHEMISTRY B LA English DT Article ID HYDROGEN-BONDING INTERACTIONS; ARENE-PERFLUOROARENE INTERACTIONS; ORGANIC ELECTROOPTIC MATERIALS; ACID-ESTER DERIVATIVES; LIQUID-CRYSTALLINE; POLYMERIC MATERIALS; CHROMOPHORES; RELAXATIONS; STABILITY; COUMARIN AB A broad nanoscopic study of a wide-range of dendritic organic nonlinear optical (NLO) self-assembly molecular glasses reveals an intermediate thermal phase regime responsible for both enhanced electric field poling properties and strong phase stabilization after poling. In this paper, the focus is on dendritic NLO molecular glasses involving quadrupolar, liquid crystal, and hydrogen bonding self-assembly mechanisms that, along with chromophore dipole dipole interactions, dictate phase stability.. Specifically, dendritic face-to-face interactions involving arene-perfluoroarene are contrasted to coumarin-containing liquid crystal mesogen and cinnamic ester hydrogen interactions. Both the strength of dendritic interactions and the impact of dipole fields on the relaxation behavior have been analyzed by nanoscale energetic probing and local thermal transition analysis: The presence of dendritic groups was found to fundamentally alter transition temperatures and the molecular relaxation behavior. Thermal transition analysis revealed that molecules with dendritic groups possess an incipient transition (T-1) preceding the glass transition temperature (T-2) that provides increased stability and a well-defined electric field poling regime (T-1 < T < T-2), in contrast to molecular groups lacking dendrons that exhibit only single transitions. On the basis of enthalpic and entropic energetic analyses, thermally active modes below T-1 were found to be intimately connected to the dendron structure. Their corresponding activation energies, which are related to thermal stability, increased moving from cinnamic ester groups to coumarin moieties to,arene-perfluoroarene interacting groups. While dendritic NLO materials were found to possess only enthalpic stabilization energies at temperatures relevant for device operation (T < T-1), the apparent molecular binding energies above T-1 contain a substantial amount (up to similar to 80%) of cooperative entropic energy. The multiple interactions (from dipole dipole interactions to local noncovalent dendritic interactions) are discussed and summarized in a model that describes the thermal transitions and phases. C1 [Knorr, Daniel B., Jr.; Krajina, Brad; Overney, Rene M.] Univ Washington, Dept Chem Engn, Seattle, WA 98195 USA. [Knorr, Daniel B., Jr.] USA, Weap & Mat Res Directorate, Res Lab, Aberdeen Proving Ground, MD 21009 USA. [Benight, Stephanie J.; Dalton, Larry R.] Univ Washington, Dept Chem, Seattle, WA 98195 USA. [Zhang, Cheng] S Dakota State Univ, Dept Chem & Biochem, Brookings, SD 57007 USA. RP Overney, RM (reprint author), Univ Washington, Dept Chem Engn, Seattle, WA 98195 USA. EM roverney@u.washington.edu FU Center for Nanotechnology (CNT) at University of Washington; National Science Foundation [DMR-0905686, EEC 0812072]; Air Force Office of Scientific Research [FA9550-09-1-0589 MOD]; NNIN Laboratory Experience for Faculty (LEF) Program at University of Washington FX This work was supported by a University Initiative Fund (UIF) graduate fellowship through the Center for Nanotechnology (CNT) at the University of Washington. D. B. Knorr thanks ARCS for a graduate fellowship. Funding support from the National Science Foundation (DMR-0905686) and the Air Force Office of Scientific Research (FA9550-09-1-0589 MOD) is gratefully acknowledged. C. Zhang is obliged to the support from National Science Foundation (EEC 0812072) and the NNIN Laboratory Experience for Faculty (LEF) Program at the University of Washington. NR 58 TC 8 Z9 8 U1 1 U2 34 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1520-6106 J9 J PHYS CHEM B JI J. Phys. Chem. B PD NOV 22 PY 2012 VL 116 IS 46 BP 13793 EP 13805 DI 10.1021/jp307370y PG 13 WC Chemistry, Physical SC Chemistry GA 042GZ UT WOS:000311461000024 PM 23098253 ER PT J AU Sheridan, RL Schaefer, PW Whalen, M Fagan, S Stoddard, FJ Schneider, JC McConkey, B Cancio, LC AF Sheridan, Robert L. Schaefer, Pamela W. Whalen, Michael Fagan, Shawn Stoddard, Frederick J., Jr. Schneider, Jeffrey C. McConkey, Brock Cancio, Leopoldo C. TI Case 36-2012: Recovery of a 16-Year-Old Girl from Trauma and Burns after a Car Accident SO NEW ENGLAND JOURNAL OF MEDICINE LA English DT Article ID POSTTRAUMATIC-STRESS-DISORDER; SEVERE HEAD-INJURY; QUALITY-OF-LIFE; BRAIN-INJURY; CHILDREN; IRAQ; MULTICENTER; SOLDIERS; MORPHINE; RETURN C1 [Sheridan, Robert L.; Fagan, Shawn] Massachusetts Gen Hosp, Burn Unit, Boston, MA 02114 USA. [Schaefer, Pamela W.] Massachusetts Gen Hosp, Dept Radiol, Boston, MA 02114 USA. [Whalen, Michael] Massachusetts Gen Hosp, Dept Psychiat, Boston, MA 02114 USA. [Sheridan, Robert L.; Fagan, Shawn] Shriners Hosp Children, Burn Unit, Sacramento, CA USA. [Stoddard, Frederick J., Jr.] Shriners Hosp Children, Dept Psychiat, Sacramento, CA USA. [Stoddard, Frederick J., Jr.] Shriners Hosp Children, Dept Prosthet, Sacramento, CA USA. [Schneider, Jeffrey C.] Spaulding Rehabil Hosp, Dept Phys Med & Rehabil, Cambridge, MA USA. [Sheridan, Robert L.] VA Boston Healthcare Syst, Dept Surg, Boston, MA USA. [Sheridan, Robert L.; Fagan, Shawn] Harvard Univ, Sch Med, Dept Surg, Boston, MA 02115 USA. [Schaefer, Pamela W.] Harvard Univ, Sch Med, Dept Radiol, Boston, MA 02115 USA. [Whalen, Michael] Harvard Univ, Sch Med, Dept Pediat, Boston, MA 02115 USA. [Stoddard, Frederick J., Jr.] Harvard Univ, Sch Med, Dept Psychiat, Boston, MA 02115 USA. [Schneider, Jeffrey C.] Harvard Univ, Sch Med, Dept Phys Med & Rehabil, Boston, MA 02115 USA. [Cancio, Leopoldo C.] Univ Texas Hlth Sci Ctr San Antonio, Dept Surg, San Antonio, TX 78229 USA. [Cancio, Leopoldo C.] USA, Inst Surg Res, San Antonio, TX USA. RP Sheridan, RL (reprint author), Massachusetts Gen Hosp, Burn Unit, Boston, MA 02114 USA. NR 34 TC 1 Z9 1 U1 1 U2 5 PU MASSACHUSETTS MEDICAL SOC PI WALTHAM PA WALTHAM WOODS CENTER, 860 WINTER ST,, WALTHAM, MA 02451-1413 USA SN 0028-4793 J9 NEW ENGL J MED JI N. Engl. J. Med. PD NOV 22 PY 2012 VL 367 IS 21 BP 2027 EP 2037 DI 10.1056/NEJMcpc1200088 PG 11 WC Medicine, General & Internal SC General & Internal Medicine GA 040RI UT WOS:000311340200012 PM 23171100 ER PT J AU Kobylinski, KC Foy, BD Richardson, JH AF Kobylinski, Kevin C. Foy, Brian D. Richardson, Jason H. TI Ivermectin inhibits the sporogony of Plasmodium falciparum in Anopheles gambiae SO MALARIA JOURNAL LA English DT Article DE Anopheles gambiae; Plasmodium falciparum; Ivermectin; Transmission ID GATED CHLORIDE CHANNEL; MALARIA TRANSMISSION; CAENORHABDITIS-ELEGANS; ONCHOCERCA-VOLVULUS; PARASITE CHITINASE; NODULISPORIC ACID; MOSQUITO SURVIVAL; VECTOR; DRUG; PRIMAQUINE AB Background: When ingested in a blood meal, ivermectin has been shown to reduce the survivorship of Anopheles gambiae in the laboratory and field. Furthermore, ivermectin mass drug administrations in Senegal have been shown to reduce the proportion of Plasmodium falciparum-sporozoite-containing An. gambiae. This study addresses whether ivermectin inhibits sporogony of P. falciparum in An. gambiae. Methods: Anophele gambiae s.s. G3 strain were fed two concentrations of ivermectin (LC25 and LC5) along with P. falciparum NF54 in human blood meals at staggered intervals. Mosquitoes ingested ivermectin concurrent with parasites (DPI 0), or at three (DPI 3), six (DPI 6), and nine (DPI 9) days post parasite ingestion, or three days prior (DPI -3) to parasite ingestion. Mosquitoes were dissected at seven, twelve or fourteen days post parasite ingestion and either oocyst or sporozoite prevalence was recorded. To determine if P. falciparum sporozoite-containing An. gambiae were more susceptible to ivermectin than uninfected controls, survivorship was recorded for mosquitoes which ingested P. falciparum or control blood meal on DPI 0 and then a second blood meal containing ivermectin (LC25) on DPI 14. Results: Ivermectin (LC25) co-ingested (DPI 0) with parasites reduced the proportion of An. gambiae that developed oocysts (chi(2) = 15.4842, P = 0.0002) and sporozoites (chi(2) = 19.9643, P < 0.0001). Ivermectin (LC25) ingested DPI 6 (chi(2) = 8.5103, P = 0.0044) and 9 (chi(2) = 14.7998, P < 0.0001) reduced the proportion of An. gambiae that developed sporozoites but not when ingested DPI 3 (chi(2) = 0.0113, P = 1). Ivermectin (LC5) co-ingested (DPI 0) with parasites did not reduce the proportion of An. gambiae that developed oocysts (chi(2) = 4.2518, P = 0.0577) or sporozoites (chi(2) = 2.3636, P = 0.1540), however, when ingested DPI -3 the proportion of An. gambiae that developed sporozoites was reduced (chi(2) = 8.4806, P = 0.0047). Plasmodium falciparum infection significantly reduced the survivorship of An. gambiae that ingested ivermectin (LC25) on DPI 14 compared to control mosquitoes that ingested a primary blood meal without parasites (chi(2) = 4.97, P = 0.0257). Conclusions: Ivermectin at sub-lethal concentrations inhibits the sporogony of P. falciparum in An. gambiae. These findings support the utility of ivermectin for P. falciparum transmission control. C1 [Kobylinski, Kevin C.; Richardson, Jason H.] Walter Reed Army Inst Res, Entomol Branch, Silver Spring, MD 20910 USA. [Foy, Brian D.] Colorado State Univ, Dept Microbiol, Arthropod Borne & Infect Dis Lab, Ft Collins, CO 80523 USA. RP Kobylinski, KC (reprint author), Walter Reed Army Inst Res, Entomol Branch, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM kevin.c.kobylinski.ctr@us.army.mil RI Richardson, Jason/A-9441-2011; Foy, Brian/E-6230-2017 OI Foy, Brian/0000-0002-9117-203X FU Military Infectious Disease Research Program; National Institutes of Health-National Institute of Allergy and Infectious Diseases [1R01AI094349-01A1] FX The authors would like to thank the Walter Reed Army Institute of Research Vector and Parasite Biology Department including Jittawadee Murphy, Megan Dowler, Tatyana Savranskaya, Dipali Patel, Clara Brando, and Alejandra Zapata for their assistance with Plasmodium falciparum culture, raising mosquitoes, and monitoring experiments, Charles White for statistical consulting, and Michael O'Neil and Michelle Colacicco-Mayhugh for critical discussion and support. This work was supported in part by the Military Infectious Disease Research Program and BDF was supported by grant 1R01AI094349-01A1 from the National Institutes of Health-National Institute of Allergy and Infectious Diseases. NR 58 TC 19 Z9 20 U1 1 U2 14 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1475-2875 J9 MALARIA J JI Malar. J. PD NOV 21 PY 2012 VL 11 AR 381 DI 10.1186/1475-2875-11-381 PG 9 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA 050XV UT WOS:000312089100001 PM 23171202 ER PT J AU Hashimoto, S Linkov, I Shaw, G Kaneko, S AF Hashimoto, Shoji Linkov, Igor Shaw, George Kaneko, Shinji TI Radioactive Contamination of Natural Ecosystems: Seeing the Wood Despite the Trees SO ENVIRONMENTAL SCIENCE & TECHNOLOGY LA English DT Article C1 [Hashimoto, Shoji; Kaneko, Shinji] Forestry & Forest Prod Res Inst, Dept Forest Site Environm, Tsukuba, Ibaraki 305, Japan. [Linkov, Igor] USA, Engineer Res & Dev Ctr, Vicksburg, MS USA. [Shaw, George] Univ Nottingham, Sch Biosci, Nottingham NG7 2RD, England. RP Hashimoto, S (reprint author), Forestry & Forest Prod Res Inst, Dept Forest Site Environm, 1 Matsunosato, Tsukuba, Ibaraki 305, Japan. EM shojih@ffpri.affrc.go.jp RI Hashimoto, Shoji/C-5785-2011 OI Hashimoto, Shoji/0000-0003-3022-7495 NR 5 TC 1 Z9 1 U1 0 U2 20 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0013-936X J9 ENVIRON SCI TECHNOL JI Environ. Sci. Technol. PD NOV 20 PY 2012 VL 46 IS 22 BP 12283 EP 12284 DI 10.1021/es304145n PG 2 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA 047WZ UT WOS:000311873500007 PM 23110301 ER PT J AU Knaack, JS Zhou, YT Abney, CW Prezioso, SM Magnuson, M Evans, R Jakubowski, EM Hardy, K Johnson, RC AF Knaack, Jennifer S. Zhou, Yingtao Abney, Carter W. Prezioso, Samantha M. Magnuson, Matthew Evans, Ronald Jakubowski, Edward M. Hardy, Katelyn Johnson, Rudolph C. TI High-Throughput Immunomagnetic Scavenging Technique for Quantitative Analysis of Live VX Nerve Agent in Water, Hamburger, and Soil Matrixes SO ANALYTICAL CHEMISTRY LA English DT Article ID CHEMICAL WARFARE AGENTS; ACETYLCHOLINESTERASE BIOSENSOR; DEGRADATION-PRODUCTS; BUTYRYLCHOLINESTERASE; EXTRACTION; PROTECTION; ELECTRODE; TOXICITY; EXPOSURE; SENSORS AB We have developed a novel immunomagnetic scavenging technique for extracting cholinesterase inhibitors from aqueous matrixes using biological targeting and antibody-based extraction. The technique was characterized using the organophosphorus nerve agent VX. The limit of detection for VX in high-performance liquid chromatography (HPLC)-grade water, defined as the lowest calibrator concentration, was 25 pg/mL in a small, 500 mu L sample. The method was characterized over the course of 22 sample sets containing calibrators, blanks, and quality control samples. Method precision, expressed as the mean relative standard deviation, was less than 9.2% for all calibrators. Quality control sample accuracy was 102% and 100% of the mean for VX spiked into HPLC-grade water at concentrations of 2.0 and 0.25 ng/mL, respectively. This method successfully was applied to aqueous extracts from soil, hamburger, and finished tap water spiked with VX. Recovery was 65%, 81%, and 100% from these matrixes, respectively. Biologically based extractions of organophosphorus compounds represent a new technique for sample extraction that provides an increase in extraction specificity and sensitivity. C1 [Knaack, Jennifer S.; Zhou, Yingtao; Hardy, Katelyn; Johnson, Rudolph C.] Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Div Sci Lab, Emergency Response & Air Toxicants Branch, Chamblee, GA 30341 USA. [Abney, Carter W.] Ctr Dis Control & Prevent, Oak Ridge Inst Sci & Educ, Chamblee, GA 30341 USA. [Prezioso, Samantha M.] Ctr Dis Control & Prevent, IHRC Inc, Atlanta, GA USA. [Magnuson, Matthew] US EPA, Cincinnati, OH 45268 USA. [Evans, Ronald; Jakubowski, Edward M.] USA, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. RP Johnson, RC (reprint author), Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Div Sci Lab, Emergency Response & Air Toxicants Branch, 4770 Buford Highway,MS F44, Chamblee, GA 30341 USA. EM RJohnson6@cdc.gov RI Abney, Carter/A-6710-2013; OI Abney, Carter/0000-0002-1809-9577 NR 22 TC 4 Z9 4 U1 1 U2 37 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0003-2700 J9 ANAL CHEM JI Anal. Chem. PD NOV 20 PY 2012 VL 84 IS 22 BP 10052 EP 10057 DI 10.1021/ac3025224 PG 6 WC Chemistry, Analytical SC Chemistry GA 055RP UT WOS:000312434800054 PM 23126363 ER PT J AU Bodhidatta, L Pitisuttithum, P Chamnanchanant, S Chang, KT Islam, D Bussaratid, V Venkatesan, MM Hale, TL Mason, CJ AF Bodhidatta, Ladaporn Pitisuttithum, Punnee Chamnanchanant, Supat Chang, Karen T. Islam, Dilara Bussaratid, Valai Venkatesan, Malabi M. Hale, Thomas L. Mason, Carl J. TI Establishment of a Shigella sonnei human challenge model in Thailand SO VACCINE LA English DT Article DE Shigella; Human challenge model; Shigella vaccine ID LIPOPOLYSACCHARIDE O-ANTIGEN; A-SECRETING CELLS; IMMUNOGLOBULIN-A; FLEXNERI 2A; ANTIBIOTIC-RESISTANCE; VACCINE DEVELOPMENT; PERIPHERAL-BLOOD; INFECTION; IMMUNOGENICITY; VOLUNTEERS AB In order to establish a human challenge model of Shigella related disease for vaccine testing, a dose-escalating inpatient trial was performed. Three groups of 12 healthy adult volunteers were orally challenged with 93,440 and 1680 CFU of Shigella sonnet strain 53G. Subjects were admitted to the Vaccine Trial Centre (VTC) at Mahidol University in Bangkok, Thailand. The primary purpose of this study was to identify the dose of S. sonnei 53G required to elicit clinical disease in at least 70% of Thai adult subjects. At the highest dose of 1680 CFU, the attack rate was 75%, while at the two lower doses, the attack rate was approximately 50%. This human challenge model, which is the first of its kind in an endemic region, will provide an opportunity for S. sonnei vaccine evaluation in endemic populations. Published by Elsevier Ltd. C1 [Bodhidatta, Ladaporn; Islam, Dilara; Mason, Carl J.] Armed Forces Res Inst Med Sci, Dept Enter Dis, Bangkok 10400, Thailand. [Pitisuttithum, Punnee; Chamnanchanant, Supat; Bussaratid, Valai] Mahidol Univ, Vaccine Trial Ctr, Fac Trop Med, Bangkok 10700, Thailand. [Chang, Karen T.] Johns Hopkins Bloomberg Sch Publ Hlth, Baltimore, MD USA. [Venkatesan, Malabi M.; Hale, Thomas L.] Walter Reed Army Inst Res, Dept Bacterial & Rickettsial Dis, Silver Spring, MD USA. RP Bodhidatta, L (reprint author), Armed Forces Res Inst Med Sci, Dept Enter Dis, 315-6 Rajvithi Rd, Bangkok 10400, Thailand. EM ladapornb@afrims.org OI MASON, CARL/0000-0002-3676-2811 FU National Institute of Allergy and Infectious Diseases (NIAID) under IAA [Y1-AI-4906-03]; Department of Defense, U.S. Army Medical Research and Materiel Command (USAMRMC) FX The authors wish to thank the clinical staff at Mahidol University; Dr. Jittima Dhitavat, Dr. Wirach Maek-a-nanthawat, Dr. Varunee Desakorn, Ms. Supa Naksrisook; Mr. Apichai Srijan and the laboratory staff at the Department of Enteric Diseases, AFRIMS; the study coordinators, Ms. Narumon Thanthamnu and Ms. Umaporn Suksawad; and the Medical Monitors, Dr. Porntep Chantavanich and Dr. Chirasak Kamboonruang, for their significant contributions to the study. The authors also thank Dr. Edwin Oaks of Walter Reed Army Institute of Research (WRAIR) for providing S. sonnei LPS. This work was supported by the National Institute of Allergy and Infectious Diseases (NIAID) under IAA # Y1-AI-4906-03 and the Department of Defense, U.S. Army Medical Research and Materiel Command (USAMRMC). NR 25 TC 6 Z9 6 U1 1 U2 6 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X J9 VACCINE JI Vaccine PD NOV 19 PY 2012 VL 30 IS 49 BP 7040 EP 7045 DI 10.1016/j.vaccine.2012.09.061 PG 6 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 050LC UT WOS:000312053800013 PM 23069701 ER PT J AU Campbell, JE Johnson, KP Rodriguez, A Cap, AP AF Campbell, James Eric Johnson, Kris P. Rodriguez, Armando Cap, Andrew P. TI Magnesium Augments Platelet Activation and Coagulation in Citrated Blood Product SO BLOOD LA English DT Meeting Abstract CT 54th Annual Meeting and Exposition of the American-Society-of-Hematology (ASH) CY DEC 08-11, 2012 CL Atlanta, GA SP Amer Soc Hematol (ASH) C1 [Campbell, James Eric; Johnson, Kris P.; Rodriguez, Armando] USA, Inst Surg Res, San Antonio, TX USA. [Cap, Andrew P.] USA, Inst Surg Res, Hollywood Pk, TX USA. NR 0 TC 0 Z9 0 U1 1 U2 2 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 2021 L ST NW, SUITE 900, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 16 PY 2012 VL 120 IS 21 MA 3438 PG 2 WC Hematology SC Hematology GA 077SZ UT WOS:000314049604089 ER PT J AU Campbell, JE Johnson, KP Rodriguez, A Cap, AP AF Campbell, James Eric Johnson, Kris P. Rodriguez, Armando Cap, Andrew P. TI Magnesium Augments Platelet Activation and Coagulation in Citrated Blood Product SO BLOOD LA English DT Meeting Abstract CT 54th Annual Meeting and Exposition of the American-Society-of-Hematology (ASH) CY DEC 08-11, 2012 CL Atlanta, GA SP Amer Soc Hematol (ASH) C1 [Campbell, James Eric; Johnson, Kris P.; Rodriguez, Armando] USA, Inst Surg Res, San Antonio, TX USA. [Cap, Andrew P.] USA, Inst Surg Res, Hollywood Pk, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 2021 L ST NW, SUITE 900, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 16 PY 2012 VL 120 IS 21 MA 3438 PG 2 WC Hematology SC Hematology GA 074UG UT WOS:000313838905051 ER PT J AU Sailasuta, N Ross, W Ananworanich, J Chalermchai, T DeGruttola, V Lerdlum, S Pothisri, M Busovaca, E Ratto-Kim, S Jagodzinski, L Spudich, S Michael, N Kim, JH Valcour, V AF Sailasuta, Napapon Ross, William Ananworanich, Jintanat Chalermchai, Thep DeGruttola, Victor Lerdlum, Sukalaya Pothisri, Mantana Busovaca, Edgar Ratto-Kim, Silvia Jagodzinski, Linda Spudich, Serena Michael, Nelson Kim, Jerome H. Valcour, Victor CA RV254 SEARCH 010 Protocol Teams TI Change in Brain Magnetic Resonance Spectroscopy after Treatment during Acute HIV Infection SO PLOS ONE LA English DT Article ID HUMAN-IMMUNODEFICIENCY-VIRUS; AIDS DEMENTIA COMPLEX; MR SPECTROSCOPY; NEUROTOXICITY; IMPAIRMENT; METABOLISM; GLUTAMATE; REGION AB Objective: Single voxel proton magnetic resonance spectroscopy (MRS) can be used to monitor changes in brain inflammation and neuronal integrity associated with HIV infection and its treatments. We used MRS to measure brain changes during the first weeks following HIV infection and in response to antiretroviral therapy (ART). Methods: Brain metabolite levels of N-acetyl aspartate (NAA), choline (tCHO), creatine (CR), myoinositol (MI), and glutamate and glutamine (GLX) were measured in acute HIV subjects (n = 31) and compared to chronic HIV+ individuals (n = 26) and HIV negative control subjects (n = 10) from Bangkok, Thailand. Metabolites were measured in frontal gray matter (FGM), frontal white matter (FWM), occipital gray matter (OGM), and basal ganglia (BG). Repeat measures were obtained in 17 acute subjects 1, 3 and 6 months following initiation of ART. Results: After adjustment for age we identified elevated BG tCHO/CR in acute HIV cases at baseline (median 14 days after HIV infection) compared to control (p = 0.0014), as well as chronic subjects (p = 0.0023). A similar tCHO/CR elevation was noted in OGM; no other metabolite abnormalities were seen between acute and control subjects. Mixed longitudinal models revealed resolution of BG tCHO/CR elevation after ART (p = 0.022) with tCHO/CR similar to control subjects at 6 months. Interpretation: We detected cellular inflammation in the absence of measurable neuronal injury within the first month of HIV infection, and normalization of this inflammation following acutely administered ART. Our findings suggest that early ART may be neuroprotective in HIV infection by mitigating processes leading to CNS injury. C1 [Busovaca, Edgar; Valcour, Victor] Univ Calif San Francisco, Dept Neurol, Memory & Aging Ctr, San Francisco, CA 94143 USA. [Sailasuta, Napapon; Ross, William] Huntington Med Res Inst, Pasadena, CA USA. [Ananworanich, Jintanat; Chalermchai, Thep] SE Asia Res Collaborat Hawaii SEARCH Thailand, Bangkok, Thailand. [Ananworanich, Jintanat; Lerdlum, Sukalaya; Pothisri, Mantana] Chulalongkorn Univ, Fac Med, Bangkok 10330, Thailand. [Ananworanich, Jintanat] Thai Red Cross AIDS Res Ctr, HIV Netherlands Australia Thailand Res Collaborat, Bangkok, Thailand. [Ratto-Kim, Silvia; Jagodzinski, Linda; Michael, Nelson; Kim, Jerome H.] Walter Reed Army Inst Res, Mil HIV Res Program, Silver Spring, MD USA. [DeGruttola, Victor] Harvard Univ, Sch Publ Hlth, Dept Biostat, Boston, MA 02115 USA. [Spudich, Serena] Yale Univ, Sch Med, Dept Neurol, New Haven, CT 06510 USA. [Valcour, Victor] Univ Calif San Francisco, Dept Med, Div Geriatr Med, San Francisco, CA USA. RP Valcour, V (reprint author), Univ Calif San Francisco, Dept Neurol, Memory & Aging Ctr, San Francisco, CA 94143 USA. EM vvalcour@memory.ucsf.edu FU National Institutes of Health [R21-MH086341, R01-MH095613, R01-NS061696, R01-NS053359]; U.S. Military HIV Research Program [W81XWH-07-2-0067]; National Cancer Institute [HHSN261200800001E]; Vaccine and Gene Therapy Institute; Gilead FX This work was funded by the National Institutes of Health grants R21-MH086341 (VV), R01-MH095613 (VV), R01-NS061696 (VV), R01-NS053359 (SRK), the U.S. Military HIV Research Program (W81XWH-07-2-0067), the National Cancer Institute (Contract No. HHSN261200800001E), and an intramural grant from the Vaccine and Gene Therapy Institute. Antiretroviral therapy was supported by Gilead (Truvada (R), Atripla (R)), Merck (Sustiva (R), Isentress (R)) and Pfizer (Selzentry (R)). Monogram Biosciences supported the Trofile (R) test. The URLs are as follows: NIH: www.nih.gov, U. S. Military HIV Research Program: www.hivresearch.org, National Cancer Institute: www.cancer.gov, Vaccine and Gene Therapy Institute: www.vgtifl.org, Gilead: www.gilead.com, Merck: www.merck.com, Pfizer: www.pfizer.com, and Monogram Biosciences: www.monogrambio.com. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.; The authors have read the journal's policy and have the following conflicts: SEARCH received a grant from Gilead. Antiretroviral therapy was supported by Gilead (Truvada (R), Atripla (R)), Merck (Sustiva (R), Isentress (R)) and Pfizer (Selzentry (R)). Monogram Biosciences supported the Trofile (R) test. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials, as detailed online in the guide for authors. NR 30 TC 36 Z9 36 U1 0 U2 12 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD NOV 16 PY 2012 VL 7 IS 11 AR e49272 DI 10.1371/journal.pone.0049272 PG 7 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 048BN UT WOS:000311885300023 PM 23229129 ER PT J AU Minnicino, MA Santare, MH AF Minnicino, Michael A. Santare, Michael H. TI Modeling the progressive damage of the microdroplet test using contact surfaces with cohesive behavior SO COMPOSITES SCIENCE AND TECHNOLOGY LA English DT Article DE Modeling; Debonding; Fracture; Interphase; Finite element analysis ID MICROBOND TEST; SHEAR-STRENGTH; COMPOSITES; INTERPHASE; INTERFACE; ADHESION AB A quarter-symmetric, three-dimensional finite element model is used to determine the stress state and progressive failure of the fiber-matrix interface during a microdroplet pull-out test of a glass fiber/epoxy matrix system. The microdroplet system interphase region is modeled using contact with cohesive behavior and is able to undergo progressive damage. The cohesive model strength and toughness are varied to determine their influence on the macro-behavior of the system and the simulations are compared to experimental results from the literature. Additionally, geometric test parameters including the blade opening, fiber free length, and fiber diameter are varied to assess their relative influence on the macro-response of the system. Published by Elsevier Ltd. C1 [Minnicino, Michael A.] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. [Minnicino, Michael A.; Santare, Michael H.] Univ Delaware, Dept Mech Engn, Newark, DE 19716 USA. [Minnicino, Michael A.; Santare, Michael H.] Univ Delaware, Ctr Composite Mat, Newark, DE 19716 USA. RP Minnicino, MA (reprint author), USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. EM michael.a.minnicino.civ@mail.mil RI Santare, Michael/B-1725-2008 NR 18 TC 7 Z9 7 U1 5 U2 26 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0266-3538 J9 COMPOS SCI TECHNOL JI Compos. Sci. Technol. PD NOV 16 PY 2012 VL 72 IS 16 BP 2024 EP 2031 DI 10.1016/j.compscitech.2012.09.009 PG 8 WC Materials Science, Composites SC Materials Science GA 039JQ UT WOS:000311242300009 ER PT J AU Crawford, CL Hauck, BC Tufariello, JA Harden, CS McHugh, V Siems, WF Hill, HH AF Crawford, C. L. Hauck, B. C. Tufariello, J. A. Harden, C. S. McHugh, V. Siems, W. F. Hill, H. H., Jr. TI Accurate and reproducible ion mobility measurements for chemical standard evaluation SO TALANTA LA English DT Article DE IMS; MS; Chemical standards; DtBP; TNT; Error estimation ID MASS-SPECTROMETRY; ATMOSPHERIC-PRESSURE; ORGANOPHOSPHORUS COMPOUNDS; ELECTROSPRAY-IONIZATION; DEGRADATION-PRODUCTS; TEMPERATURE; RESOLUTION; DEPENDENCE AB Chemical standards are used to calibrate ion mobility spectrometers (IMS) for accurate and precise identification of target compounds. Research over the past 30 years has identified several positive and negative mode compounds that have been used as IMS standards. However, the IMS research community has not come to a consensus on any chemical compound(s) for use as a reference standard. Also, the reported K-0 values for the same compound analyzed on several IMS systems can be inconsistent. In many cases, mobility has not been correlated with a mass identification of an ion. The primary goal of this work was to provide mass-identified mobility (K-0) values for standards. The results of this work were mass-identified K-0 values for positive and negative mode IMS chemical standards. The negative mode results of this study showed that TNT is a viable negative mode reference standard. New temperature-dependent K-0 values were found by characterizing drift gas temperature and water content; several examples were found of temperature-dependent changes for the ion species of several standards. The overall recommendation of this study is that proposed IMS standards should have temperature-dependent K-0 values quoted in the literature instead of using a single K-0 value for a compound. (C) 2012 Elsevier B.V. All rights reserved. C1 [Crawford, C. L.; Hauck, B. C.; Tufariello, J. A.; Siems, W. F.; Hill, H. H., Jr.] Washington State Univ, Dept Chem, Pullman, WA 99164 USA. [Harden, C. S.; McHugh, V.] USA, Edgewood Chem & Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. RP Hill, HH (reprint author), Washington State Univ, Dept Chem, POB 644630, Pullman, WA 99164 USA. EM hhhill@wsu.edu FU Science Applications International Corporation; U.S. Army Edgewood Chemical and Biological Center [DAAD13-03-D-0017, DO 0065, P010058810] FX This work was supported by the Science Applications International Corporation and the U.S. Army Edgewood Chemical and Biological Center for the funding under Prime contract DAAD13-03-D-0017, DO 0065, Subcontract #P010058810. NR 46 TC 11 Z9 11 U1 2 U2 32 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0039-9140 J9 TALANTA JI Talanta PD NOV 15 PY 2012 VL 101 BP 161 EP 170 DI 10.1016/j.talanta.2012.09.003 PG 10 WC Chemistry, Analytical SC Chemistry GA 064OH UT WOS:000313084400025 PM 23158307 ER PT J AU Xing, LD Vatamanu, J Borodin, O Smith, GD Bedrov, D AF Xing, Lidan Vatamanu, Jenel Borodin, Oleg Smith, Grant D. Bedrov, Dmitry TI Electrode/Electrolyte Interface in Sulfolane-Based Electrolytes for Li Ion Batteries: A Molecular Dynamics Simulation Study SO JOURNAL OF PHYSICAL CHEMISTRY C LA English DT Article ID SULFONE-BASED ELECTROLYTES; 2-DIMENSIONAL PERIODICITY; 3-DIMENSIONAL SYSTEMS; DIFFERENTIAL CAPACITANCE; RAPID CALCULATION; ELECTROCHEMICAL PROPERTIES; GRAPHITE-ELECTRODES; COULOMB COMPONENT; STRESS TENSOR; LITHIUM AB The double layer composition and structure of the mixed-solvent electrolyte tetramethylene sulfone/dimethyl carbonate (TMS/DMC) doped with LiPF6 near the graphite surface have been investigated using molecular dynamics simulations as a function of applied potential between the electrodes ranging from 0 to 6 V. Three solvent compositions, with TMS/DMC ratios of 1:2, 1:1, and 2:1 doped with LiPF6 salt, were investigated. At uncharged electrodes, electrolyte composition at the interfaces was found to be similar to that of bulk electrolyte for TMS/DMC ratios of 1:1 and 1:2 systems but deviated from the bulk for a TMS/DMC ratio of 2:1. At negative electrodes the polar solvent TMS preferentially adsorbs at the electrode surface displacing the almost nonpolar DMC solvent. The preferential partitioning of TMS relative to DMC to the negative electrode surface is consistent with the stronger binding of the former with Li+ that partitions to the anode surface as potential becomes more negative as well as with the ability of relatively polar TMS to better respond to the electrostatic potential near a charged surface. At the positive electrode, TMS/DMC ratios were found to be similar to bulk compositions that is different to the behavior observed in ethylene carbonate (EC)/DMC/LiPF6 electrolyte where preferential partitioning of a more polar EC molecule was observed on both electrodes. Our results also show that, in TMS/DMC/LiPF6 electrolyte, DMC is located approximately 0.8 angstrom further way from the positive electrode than in EC/DMC/LiPF6 indicating that it might be more difficult to oxidize DMC in the TMS-based electrolytes that is consistent with experimentally reported increased oxidative stability of the latter. Finally, changes of the Li+ solvation shell and double layer capacitance were analyzed as a function of electrode potential. C1 [Xing, Lidan; Vatamanu, Jenel; Bedrov, Dmitry] Univ Utah, Dept Mat Sci & Engn, Salt Lake City, UT 84112 USA. [Xing, Lidan] S China Normal Univ, Sch Chem & Environm, Guangzhou 510006, Guangdong, Peoples R China. [Borodin, Oleg] Army Res Lab, Electrochem Branch, Adelphi, MD 20783 USA. [Smith, Grant D.] Wasatch Mol Inc, Salt Lake City, UT 84103 USA. RP Vatamanu, J (reprint author), Univ Utah, Dept Mat Sci & Engn, 122 S Cent Campus Dr, Salt Lake City, UT 84112 USA. EM jenel.vatamanu@utah.edu RI Borodin, Oleg/B-6855-2012; Vatamanu, Jenel/I-7638-2012 OI Borodin, Oleg/0000-0002-9428-5291; Vatamanu, Jenel/0000-0003-0825-1608 FU Office of Vehicle Technologies of the U.S. Department of Energy [DE-AC02-05CH11231]; Office of Vehicle Technologies of the U.S. Department of Energy under the Batteries for Advanced Transportation Technologies (BATT) Program [6838611]; U.S. Department of Energy; U.S. Army Research Laboratory [DE-IA01-11EE003413]; Natural Science Foundation of Guangdong Province, China [1035106310 1000001] FX This work was supported by the Assistant Secretary for Energy Efficiency and Renewable Energy, Office of Vehicle Technologies of the U.S. Department of Energy under contract no. DE-AC02-05CH11231, subcontract no. 6838611 under the Batteries for Advanced Transportation Technologies (BATT) Program, and via an Interagency Agreement between the U.S. Department of Energy and the U.S. Army Research Laboratory under DE-IA01-11EE003413. L.X. acknowledges financial support of the Natural Science Foundation of Guangdong Province, China (grant no. 1035106310 1000001). NR 56 TC 40 Z9 43 U1 8 U2 128 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1932-7447 J9 J PHYS CHEM C JI J. Phys. Chem. C PD NOV 15 PY 2012 VL 116 IS 45 BP 23871 EP 23881 DI 10.1021/jp3054179 PG 11 WC Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary SC Chemistry; Science & Technology - Other Topics; Materials Science GA 038RC UT WOS:000311190800004 ER PT J AU Dawley, MM Scott, AM Hill, FC Leszczynski, J Orlando, TM AF Dawley, M. Michele Scott, Andrea Michalkoya Hill, Frances C. Leszczynski, Jerzy Orlando, Thomas M. TI Adsorption of Formamide on Kaolinite Surfaces: A Combined Infrared Experimental and Theoretical Study SO JOURNAL OF PHYSICAL CHEMISTRY C LA English DT Article ID INTERCALATED KAOLINITES; DENSITY FUNCTIONALS; LOW-TEMPERATURE; 77 K; VIBRATIONAL SPECTROSCOPY; NONCOVALENT INTERACTIONS; THERMOCHEMICAL KINETICS; RAMAN-SPECTROSCOPY; AB-INITIO; DICKITE AB The interaction of formamide with kaolinite has been studied using transmission Fourier transform-infrared spectroscopy (FT-IR) and temperature programmed desorption (TPD) under ultra-high vacuum conditions. The theoretical harmonic infrared frequencies have been calculated using M05-2X/6-31G(d), 6-31G(d,p), and 6-31+G(d,p) levels of density functional theory, and general agreement with experiment has been found for condensed formamide and the formamide-kaolinite surface complexes. The kaolinite OH band positions change as a function of temperature, which have been previously correlated with surface reconstructions and changes in interlayer bond distances in the kaolinite. The temperature dependence of the kaolinite OH and formamide vibrational frequencies can be sensitive probes of formamide interactions with the exposed and interlayer surfaces of kaolinite. Samples dosed directly with formamide show that the C=O stretching feature is broadened and shifts to lower frequency at low temperatures (67-90 K). The NH and CH stretches of formamide are also very weak at these temperatures. We interpret these features as manifestations of hydrogen bonding between the Al-OH octahedral kaolinite face (inner surface OH group) and formamide's carbonyl group. Intercalation and subsequent bonding may be facilitated by the increased O-H center dot center dot center dot O bond lengths between kaolinite lattices and increased availability of Al-OH sites in the low-temperature regime. At 100-110 K, the C=O feature sharpens and shifts to a higher frequency, while the NH and CH stretches become more distinct. With increasing temperature, formamide diffusion and formamide-formamide interactions become more dominant. TPD analysis gives a mean binding energy of 11.7 +/- 0.24 kcal/mol, which agrees well with the calculated values of adsorption energy and indicates strong physisorption. C1 [Dawley, M. Michele; Orlando, Thomas M.] Georgia Inst Technol, Sch Chem & Biochem, Atlanta, GA 30332 USA. [Scott, Andrea Michalkoya; Leszczynski, Jerzy] Jackson State Univ, Dept Chem, Interdisciplinary Nanotox Ctr, Jackson, MS 39217 USA. [Scott, Andrea Michalkoya; Hill, Frances C.; Leszczynski, Jerzy] USA, ERDC, Vicksburg, MS 39180 USA. RP Orlando, TM (reprint author), Georgia Inst Technol, Sch Chem & Biochem, 901 Atlantic Dr, Atlanta, GA 30332 USA. EM thomas.orlando@chemistry.gatech.edu FU NSF [0730186]; NASA Astrobiology Program, under the NSF Center for Chemical Evolution, [CHE-1004570] FX This work was jointly supported by the NSF and the NASA Astrobiology Program, under the NSF Center for Chemical Evolution, CHE-1004570. This work was also facilitated by the NSF grant EXP-LA no. 0730186. Some of the theoretical data presented herein were obtained by A.M.S. and F.C.H. under the Environmental Quality Technology Program of the United States Army Corps of Engineers by the USAERDC. Permission was granted by the Chief of Engineers to publish this information. The findings of this contribution are not to be construed as an official Department of the Army position unless so designated by other authorized documents. NR 64 TC 16 Z9 16 U1 4 U2 55 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1932-7447 J9 J PHYS CHEM C JI J. Phys. Chem. C PD NOV 15 PY 2012 VL 116 IS 45 BP 23981 EP 23991 DI 10.1021/jp304529n PG 11 WC Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary SC Chemistry; Science & Technology - Other Topics; Materials Science GA 038RC UT WOS:000311190800018 ER PT J AU Scott, AM Dawley, MM Orlando, TM Hill, FC Leszczynski, J AF Scott, Andrea Michalkova Dawley, M. Michele Orlando, Thomas M. Hill, Frances C. Leszczynski, Jerzy TI Theoretical Study of the Roles of Na+ and Water on the Adsorption of Formamide on Kaolinite Surfaces SO JOURNAL OF PHYSICAL CHEMISTRY C LA English DT Article ID INITIO MOLECULAR-DYNAMICS; AB-INITIO; CLAY-MINERALS; DENSITY FUNCTIONALS; NONCOVALENT INTERACTIONS; THERMOCHEMICAL KINETICS; INTERCALATION COMPOUNDS; N-METHYLFORMAMIDE; CRYSTAL-STRUCTURE; GUEST MOLECULES AB The adsorption of formamide (FA) on kaolinite surfaces and the roles of Na+ and water on the adsorption were investigated theoretically using a density functional theory. The calculations reveal that adsorbed FA is able to form stable complexes with the tetrahedral and octahedral surfaces of kaolinite. The octahedral surface possesses a larger binding affinity toward FA than the tetrahedral site of kaolinite partially due to the presence of the surface hydroxyl groups that are more active in the intermolecular interactions than the basal oxygen atoms of the siloxane or tetrahedral sites. The calculated (basis set superposition error corrected) binding energies of FA on the kaolinite octahedral and tetrahedral surfaces are -14.8 and -13.7 kcal/mol, respectively. FA also forms slightly less stable complexes with the negatively charged kaolinite fragments than with neutral ones. The addition of a sodium cation plays a key role in this adsorption, while addition of one water molecule affects the binding strength insignificantly. A chemical reaction occurs involving the Na octahedral surface complex, during which hydrogen is removed from FA and binds with the surface oxygen. Full solvation decreases the adsorption affinity of FA toward both kaolinite surfaces. Estimated Gibbs free energies indicate that the adsorption of FA on most of the studied kaolinite clusters is thermodynamically feasible from both gas phase and water solution. C1 [Scott, Andrea Michalkova; Leszczynski, Jerzy] Jackson State Univ, Dept Chem, Interdisciplinary Nanotox Ctr, Jackson, MS 39217 USA. [Scott, Andrea Michalkova; Hill, Frances C.; Leszczynski, Jerzy] USA, ERDC, Vicksburg, MS 39180 USA. [Dawley, M. Michele; Orlando, Thomas M.] Georgia Inst Technol, Sch Chem & Biochem, Atlanta, GA 30332 USA. RP Leszczynski, J (reprint author), Jackson State Univ, Dept Chem, Interdisciplinary Nanotox Ctr, 1400 Lynch St,POB 17910, Jackson, MS 39217 USA. EM jerzy@icnanotox.org FU NSF [0730186]; NASA Astrobiology Program, under the NSF Center for Chemical Evolution [CHE-1004570] FX This work was jointly supported by NSF and the NASA Astrobiology Program, under the NSF Center for Chemical Evolution, CHE-1004570. This work was also facilitated by the NSF Grant EXP-LA No. 0730186. Some of the data presented herein were also obtained from research conducted by A.M.S. and F.C.H. under the Environmental Quality Technology Program of the United States Army Corps of Engineers by the USAERDC. Permission was granted by the Chief of Engineers to publish this information. The findings of this report are not to be construed as an official Department of the Army position unless so designated by other authorized documents. NR 67 TC 18 Z9 18 U1 0 U2 40 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1932-7447 J9 J PHYS CHEM C JI J. Phys. Chem. C PD NOV 15 PY 2012 VL 116 IS 45 BP 23992 EP 24005 DI 10.1021/jp3045324 PG 14 WC Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary SC Chemistry; Science & Technology - Other Topics; Materials Science GA 038RC UT WOS:000311190800019 ER PT J AU Schuster, BE Roszell, LE Murr, LE Ramirez, DA Demaree, JD Klotz, BR Rosencrance, AB Dennis, WE Bao, W Perkins, EJ Dillman, JF Bannon, DI AF Schuster, B. E. Roszell, L. E. Murr, L. E. Ramirez, D. A. Demaree, J. D. Klotz, B. R. Rosencrance, A. B. Dennis, W. E. Bao, W. Perkins, E. J. Dillman, J. F. Bannon, D. I. TI In vivo corrosion, tumor outcome, and microarray gene expression for two types of muscle-implanted tungsten alloys SO TOXICOLOGY AND APPLIED PHARMACOLOGY LA English DT Article DE Tungsten alloy; Nickel; Cobalt; Rhabdomyosarcoma; Microarray; MDM2 ID OXIDATIVE DNA-DAMAGE; NICKEL SUBSULFIDE; AMPLIFICATION; CELLS; MDM2; INDUCTION; SARCOMAS; RATS; CDK4; CARCINOGENESIS AB Tungsten alloys are composed of tungsten microparticles embedded in a solid matrix of transition metals such as nickel, cobalt, or iron. To understand the toxicology of these alloys, male F344 rats were intramuscularly implanted with pellets of tungsten/nickel/cobalt, tungsten/nickel/iron, or pure tungsten, with tantalum pellets as a negative control. Between 6 and 12 months, aggressive rhabdomyosarcomas formed around tungsten/nickel/cobalt pellets, while those of tungsten/nickel/iron or pure tungsten did not cause cancers. Electron microscopy showed a progressive corrosion of the matrix phase of tungsten/nickel/cobalt pellets over 6 months, accompanied by high urinary concentrations of nickel and cobalt. In contrast, non-carcinogenic tungsten/nickel/iron pellets were minimally corroded and urinary metals were low; these pellets having developed a surface oxide layer in vivo that may have restricted the mobilization of carcinogenic nickel. Microarray analysis of tumors revealed large changes in gene expression compared with normal muscle, with biological processes involving the cell cycle significantly up-regulated and those involved with muscle development and differentiation significantly down-regulated. Top KEGG pathways disrupted were adherens junction, p53 signaling, and the cell cycle. Chromosomal enrichment analysis of genes showed a highly significant impact at cytoband 7q22 (chromosome 7) which included mouse double minute (MDM2) and cyclin-dependant kinase (CDK4) as well as other genes associated with human sarcomas. In conclusion, the tumorigenic potential of implanted tungsten alloys is related to mobilization of carcinogenic metals nickel and cobalt from corroding pellets, while gene expression changes in the consequent tumors are similar to radiation induced animal sarcomas as well as sporadic human sarcomas. Published by Elsevier Inc. C1 [Roszell, L. E.; Bannon, D. I.] USN, Inst Publ Hlth, Aberdeen Proving Ground, MD 21010 USA. [Schuster, B. E.; Demaree, J. D.] USN, Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. [Murr, L. E.; Ramirez, D. A.] Univ Texas El Paso, Dept Met & Mat Engn, El Paso, TX 79968 USA. [Klotz, B. R.] Dynamic Sci Inc, Aberdeen Proving Ground, MD 21005 USA. [Rosencrance, A. B.; Dennis, W. E.] USA, Ctr Environm Hlth Res, Dept Chem, Ft Detrick, MD 21702 USA. [Bao, W.] SAS Inst Inc, Cary, NC 27513 USA. [Perkins, E. J.] USN, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. [Dillman, J. F.] USN, Med Res Inst Chem Def, Aberdeen Proving Ground, MD 21010 USA. RP Bannon, DI (reprint author), USN, Inst Publ Hlth, Bldg E2100, Aberdeen Proving Ground, MD 21010 USA. EM desmond.bannon@us.army.mil OI Murr, Lawrence/0000-0001-5942-8376 FU U.S. Army Public Health Command; Aberdeen Proving Ground, MD FX This work was funded by the U.S. Army Public Health Command, Aberdeen Proving Ground, MD (formerly U.S. Army Center for Health Promotion and Preventive Medicine). Grateful thanks to Pat Beall, Terry Hanna, Bob Sunderland and technical support staff at AIPH. We thank Dr. William Eck for technical review of the manuscript, and Dr. Mark Johnson and COL Chris Hanson for helpful comments. Microarray work carried out by C.S. Phillips at MRICD. NR 49 TC 9 Z9 9 U1 2 U2 21 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0041-008X J9 TOXICOL APPL PHARM JI Toxicol. Appl. Pharmacol. PD NOV 15 PY 2012 VL 265 IS 1 BP 128 EP 138 DI 10.1016/j.taap.2012.08.025 PG 11 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA 037WD UT WOS:000311136300014 PM 22982072 ER PT J AU Yang, S Cai, Y Cheng, YW Varanasi, CV Liu, J AF Yang, Sungwoo Cai, Yue Cheng, Yingwen Varanasi, C. V. Liu, Jie TI Monolithic co-aerogels of carbon/titanium dioxide as three dimensional nanostructured electrodes for energy storage SO JOURNAL OF POWER SOURCES LA English DT Article DE Carbon aerogels; TiO2 aerogels; Sol-gel; Monolith; Lithium ion batteries ID LITHIUM ION BATTERIES; INTERPENETRATING ELECTROCHEMICAL-CELL; ANATASE TIO2 NANOSHEETS; TITANIUM-DIOXIDE; PARTICLE-SIZE; PERFORMANCE; NANOTUBES; NANOCOMPOSITES; INTERCALATION; CAPABILITY AB Conductive fillers, such as amorphous carbon, carbon nanotube and graphene etc., are generally mixed with nanostructured metal oxide materials to improve the performance of electrode materials in energy storage devices. However, the conductive framework that provides path for electric conduction does not normally form a well-connected and robust 3-D network to ensure optimized ions transport. Here, we report a convenient, inexpensive and scalable method for synthesizing hybrid carbon and titanium dioxide co-gels and co-aerogels to improve the electrochemical capacity by combining both the lithium insertion and the surface storage mechanisms in Li ion batteries (LIBs) anodes. A monolithic piece of a hybrid C/TiO2 co-aerogel can be directly used as an active electrode without the addition of binders, such as polyvinylidene fluoride (PVDF). As a result, the performance of LIB anodes using the hybrid co-aerogel is significantly improved over current LIBs based on carbon/titanium oxide composites. The reversible discharge capacity was stabilized at similar to 400 mAh g(-1) at a 168 mA g(-1) scan rate and an operating voltage between 3.0 and 0.05 V vs. Li+/Li with excellent cyclic capacity retention. This approach, however, is not limited to only C/TiO2 system but can be extended to other metal oxides to form co-gels with carbon to improve their potential use in numerous electrochemical, photocatalytic, and photoelectronic devices. (C) 2012 Elsevier B.V. All rights reserved. C1 [Yang, Sungwoo; Cai, Yue; Cheng, Yingwen; Liu, Jie] Duke Univ, Dept Chem, Durham, NC 27708 USA. [Varanasi, C. V.] USA, Res Off, Res Triangle Pk, NC 27709 USA. RP Liu, J (reprint author), Duke Univ, Dept Chem, Durham, NC 27708 USA. EM j.liu@duke.edu RI Cheng, Yingwen/B-2202-2012; Liu, Jie/B-4440-2010; Yang, Sungwoo/G-4484-2011 OI Cheng, Yingwen/0000-0002-0778-5504; Liu, Jie/0000-0003-0451-6111; Yang, Sungwoo/0000-0002-6557-4940 FU Army Research Office (ARO) [W911NF-04-D-0001]; National Science Foundation (NSF) [EF-0830093]; Environmental Protection Agency (EPA) under NSF [EF-0830093]; Duke SMIF (Shared Materials Instrumentation Facilities) FX This work is in part supported by a research grant from Army Research Office (ARO) under contract W911NF-04-D-0001 and the National Science Foundation (NSF) and the Environmental Protection Agency (EPA) under NSF Cooperative Agreement EF-0830093, Center for the Environmental Implications of NanoTechnology (CEINT). Any opinions, findings, conclusions or recommendations expressed in this material are those of the author(s) and do not necessarily reflect the views of the NSF or the EPA. This work has not been subjected to EPA review and no official endorsement should be inferred. The authors also acknowledge the support from Duke SMIF (Shared Materials Instrumentation Facilities). NR 57 TC 13 Z9 13 U1 3 U2 161 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0378-7753 J9 J POWER SOURCES JI J. Power Sources PD NOV 15 PY 2012 VL 218 BP 140 EP 147 DI 10.1016/j.jpowsour.2012.06.070 PG 8 WC Chemistry, Physical; Electrochemistry; Energy & Fuels; Materials Science, Multidisciplinary SC Chemistry; Electrochemistry; Energy & Fuels; Materials Science GA 009PQ UT WOS:000309038100023 ER PT J AU Gates, DH Darter, BJ Dingwell, JB Wilken, JM AF Gates, Deanna H. Darter, Benjamin J. Dingwell, Jonathan B. Wilken, Jason M. TI Comparison of walking overground and in a Computer Assisted Rehabilitation Environment (CAREN) in individuals with and without transtibial amputation SO JOURNAL OF NEUROENGINEERING AND REHABILITATION LA English DT Article DE Treadmill; Kinematics; Virtual reality; Rehabilitation ID LOCAL DYNAMIC STABILITY; HUMAN JOINT MOTION; TREADMILL WALKING; KINEMATIC VARIABILITY; ISB RECOMMENDATION; GAIT ANALYSIS; ENERGY-COST; OPTIC FLOW; LOCOMOTION; DEFINITIONS AB Background: Due to increased interest in treadmill gait training, recent research has focused on the similarities and differences between treadmill and overground walking. Most of these studies have tested healthy, young subjects rather than impaired populations that might benefit from such training. These studies also do not include optic flow, which may change how the individuals integrate sensory information when walking on a treadmill. This study compared overground walking to treadmill walking in a computer assisted virtual reality environment (CAREN) in individuals with and without transtibial amputations (TTA). Methods: Seven individuals with traumatic TTA and 27 unimpaired controls participated. Subjects walked overground and on a treadmill in a CAREN at a normalized speed. The CAREN applied optic flow at the same speed that the subject walked. Temporal-spatial parameters, full body kinematics, and kinematic variability were collected during all trials. Results: Both subject groups decreased step time and control subjects decreased step length when walking in the CAREN. Differences in lower extremity kinematics were small (<2.5.) and did not exceed the minimal detectable change values for these measures. Control subjects exhibited decreased transverse and frontal plane range of motion of the pelvis and trunk when walking in the CAREN, while patients with TTA did not. Both groups exhibited increased step width variability during treadmill walking in the CAREN, but only minor changes in kinematic variability. Conclusions: The results of this study suggest that treadmill training in a virtual environment should be similar enough to overground that changes should carry over. Caution should be made when comparing step width variability and step time results from studies utilizing a treadmill to those overground. C1 [Gates, Deanna H.; Darter, Benjamin J.; Wilken, Jason M.] Brooke Army Med Ctr, Ctr Intrepid, Dept Orthopaed & Rehabil, Ft Sam Houston, TX 78234 USA. [Darter, Benjamin J.] Virginia Commonwealth Univ, Dept Phys Therapy, Richmond, VA 23298 USA. [Dingwell, Jonathan B.] Univ Texas Austin, Dept Kinesiol & Hlth Educ, Austin, TX 78712 USA. RP Wilken, JM (reprint author), Brooke Army Med Ctr, Ctr Intrepid, Dept Orthopaed & Rehabil, Ft Sam Houston, TX 78234 USA. EM jason.wilken@us.army.mil OI Dingwell, Jonathan/0000-0001-6990-4153; Wilken, Jason/0000-0002-5556-7667 FU Military Amputee Research Program FX This work was supported by the Military Amputee Research Program. The authors would like to thank Emily Sinitski, Kiril Sinitski, and Jordan Sturdy for their help with data collection and data processing. NR 40 TC 11 Z9 12 U1 0 U2 84 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1743-0003 J9 J NEUROENG REHABIL JI J. NeuroEng. Rehabil. PD NOV 14 PY 2012 VL 9 AR 81 DI 10.1186/1743-0003-9-81 PG 10 WC Engineering, Biomedical; Neurosciences; Rehabilitation SC Engineering; Neurosciences & Neurology; Rehabilitation GA 072DE UT WOS:000313648100001 PM 23150903 ER PT J AU Shaw, LJ Hausleiter, J Achenbach, S Al-Mallah, M Berman, DS Budoff, MJ Cademartiri, F Callister, TQ Chang, HJ Kim, YJ Cheng, VY Chow, BJW Cury, RC Delago, AJ Dunning, AL Feuchtner, GM Hadamitzky, M Karlsberg, RP Kaufmann, PA Leipsic, J Lin, FY Chinnaiyan, KM Maffei, E Raff, GL Villines, TC LaBounty, T Gomez, MJ Min, JK AF Shaw, Leslee J. Hausleiter, Joerg Achenbach, Stephan Al-Mallah, Mouaz Berman, Daniel S. Budoff, Matthew J. Cademartiri, Fillippo Callister, Tracy Q. Chang, Hyuk-Jae Kim, Yong-Jin Cheng, Victor Y. Chow, Benjamin J. W. Cury, Ricardo C. Delago, Augustin J. Dunning, Allison L. Feuchtner, Gudrun M. Hadamitzky, Martin Karlsberg, Ronald P. Kaufmann, Philipp A. Leipsic, Jonathon Lin, Fay Y. Chinnaiyan, Kavitha M. Maffei, Erica Raff, Gilbert L. Villines, Todd C. LaBounty, Troy Gomez, Millie J. Min, James K. CA CONFIRM Registry Investigators TI Coronary Computed Tomographic Angiography as a Gatekeeper to Invasive Diagnostic and Surgical Procedures SO JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY LA English DT Article DE coronary computed tomography; health services research; prognosis; resource utilization ID INTERNATIONAL MULTICENTER REGISTRY; ARTERY-DISEASE; CT ANGIOGRAPHY; MYOCARDIAL-PERFUSION; CLINICAL-OUTCOMES; PROGNOSTIC VALUE; SYMPTOMATIC PATIENTS; BYPASS PATIENTS; MORTALITY RISK; STRESS TESTS AB Objectives This study sought to examine patterns of follow-up invasive coronary angiography (ICA) and revascularization (REV) after coronary computed tomography angiography (CCTA). Background CCTA is a noninvasive test that permits direct visualization of the extent and severity of coronary artery disease (CAD). Post-CCTA patterns of follow-up ICA and REV are incompletely defined. Methods We examined 15,207 intermediate likelihood patients from 8 sites in 6 countries; these patients were without known CAD, underwent CCTA, and were followed up for 2.3 +/- 1.2 years for all-cause mortality. Coronary artery stenosis was judged as obstructive when >= 50% stenosis was present. A multivariable logistic regression was used to estimate ICA use. A Cox proportional hazards model was used to estimate all-cause mortality. Results During follow-up, ICA rates for patients with no CAD to mild CAD according to CCTA were low (2.5% and 8.3%), with similarly low rates of REV (0.3% and 2.5%). Most ICA procedures (79%) occurred <= 3 months of CCTA. Obstructive CAD was associated with higher rates of ICA and REV for 1-vessel (44.3% and 28.0%), 2-vessel (53.3% and 43.6%), and 3-vessel (69.4% and 66.8%) CAD, respectively. For patients with <50% stenosis, early ICA rates were elevated; over the entirety of follow-up, predictors of ICA were mild left main, mild proximal CAD, respectively, or higher coronary calcium scores. In patients with <50% stenosis, the relative hazard for death was 2.2 (p = 0.011) for ICA versus no ICA. Conversely, for patients with CAD, the relative hazard for death was 0.61 for ICA versus no ICA (p = 0.047). Conclusions These findings support the concept that CCTA may be used effectively as a gatekeeper to ICA. (J Am Coll Cardiol 2012;60:2103-14) (C) 2012 by the American College of Cardiology Foundation C1 [Shaw, Leslee J.] Emory Univ, Sch Med, Emory Clin Cardiovasc Res Inst, Dept Med, Atlanta, GA 30306 USA. [Hausleiter, Joerg] Tech Univ Munich, Div Cardiol, Munich, Germany. [Achenbach, Stephan] Univ Erlangen Nurnberg, Dept Med, D-91054 Erlangen, Germany. [Al-Mallah, Mouaz] Wayne State Univ, Dept Med, Henry Ford Hosp, Detroit, MI 48202 USA. [Berman, Daniel S.; Cheng, Victor Y.; LaBounty, Troy; Gomez, Millie J.; Min, James K.] Cedars Sinai Med Ctr, Dept Imaging, Los Angeles, CA 90048 USA. [Budoff, Matthew J.] Harbor UCLA Med Ctr, Dept Med, Los Angeles, CA USA. [Cademartiri, Fillippo; Maffei, Erica] Giovanni XXIII Hosp, Cardiovasc Imaging Unit, Monastier Di Treviso, Italy. [Cademartiri, Fillippo] Erasmus MC, Dept Radiol, Rotterdam, Netherlands. [Callister, Tracy Q.] Tennesse Heart & Vasc Inst, Hendersoville, TN USA. [Callister, Tracy Q.] Severance Cardiovasc Hosp, Div Cardiol, Seoul, South Korea. [Chow, Benjamin J. W.] Univ Ottawa, Inst Heart, Dept Med Cardiol, Ottawa, ON, Canada. [Cury, Ricardo C.] Baptist Hosp Miami, Miami, FL USA. [Cury, Ricardo C.] Baptist Cardiac & Vasc Inst, Miami, FL USA. [Delago, Augustin J.] Capitol Cardiol Associates, Albany, NY USA. [Dunning, Allison L.] Weill Cornell Med Coll, Dept Publ Hlth, New York, NY USA. [Dunning, Allison L.] New York Presbyterian Hosp, New York, NY USA. [Feuchtner, Gudrun M.] Innsbruck Med Univ, Dept Radiol 2, Innsbruck, Austria. [Kaufmann, Philipp A.] Univ Zurich Hosp, CH-8091 Zurich, Switzerland. [Leipsic, Jonathon] Univ British Columbia, Dept Radiol, St Pauls Hosp, Vancouver, BC, Canada. [Chinnaiyan, Kavitha M.; Raff, Gilbert L.] William Beaumont Hosp, Dept Cardiol, Royal Oak, MI 48072 USA. [Villines, Todd C.] Walter Reed Army Med Ctr, Dept Med, Washington, DC 20307 USA. RP Shaw, LJ (reprint author), Emory Univ, Sch Med, Emory Clin Cardiovasc Res Inst, Dept Med, 1462 Clifton Rd NE,Room 529, Atlanta, GA 30306 USA. EM leslee.shaw@emory.edu RI Cademartiri, Filippo/H-7336-2015; Maffei, Erica/J-2370-2016 OI Cademartiri, Filippo/0000-0002-0579-3279; Maffei, Erica/0000-0002-0388-4433 FU Siemens FX Dr. Hausleiter is a consultant to Siemens Medical Solutions and Abbott Laboratories. Dr. Achenbach has received research grants from Siemens. Dr. Cademartiri is a consultant to Guerbert and Servier; and is on the Speaker's Bureau of Bracco. Dr. Chow is a consultant to GE Healthcare, TeraRecon, Pfizer, and AstraZeneca. Dr. Leipsic is on the Speaker's Bureau and is a member of the Medical Advisory Board to GE Healthcare. Dr. Maffei is a consultant to Servier and GE Healthcare. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose. NR 36 TC 52 Z9 54 U1 0 U2 7 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0735-1097 J9 J AM COLL CARDIOL JI J. Am. Coll. Cardiol. PD NOV 13 PY 2012 VL 60 IS 20 BP 2103 EP 2114 DI 10.1016/j.jacc.2012.05.062 PG 12 WC Cardiac & Cardiovascular Systems SC Cardiovascular System & Cardiology GA 033GW UT WOS:000310783200016 PM 23083780 ER PT J AU Brandt, HE AF Brandt, Howard E. TI ASPECTS OF THE RIEMANNIAN GEOMETRY OF QUANTUM COMPUTATION SO INTERNATIONAL JOURNAL OF MODERN PHYSICS B LA English DT Article DE Quantum computing; quantum circuits; quantum complexity; differential geometry; Riemannian geometry; geodesics; Lax equation; Jacobi fields; geodesic derivative AB A review is given of some aspects of the Riemannian geometry of quantum computation in which the quantum evolution is represented in the tangent space manifold of the special unitary unimodular group SU(2(n)) for n qubits. The Riemannian right-invariant metric, connection, curvature, geodesic equation for minimal complexity quantum circuits, Jacobi equation and the lifted Jacobi equation for varying penalty parameter are reviewed. Sharpened tools for calculating the geodesic derivative are presented. The geodesic derivative may facilitate the numerical investigation of conjugate points and the global characteristics of geodesic paths in the group manifold, the determination of optimal quantum circuits for carrying out a quantum computation, and the determination of the complexity of particular quantum algorithms. C1 USA, Res Lab, Adelphi, MD USA. RP Brandt, HE (reprint author), USA, Res Lab, Adelphi, MD USA. EM howard.e.brandt.civ@mail.mil FU U.S. Army Research Laboratory FX This research was supported by the U.S. Army Research Laboratory. NR 45 TC 2 Z9 3 U1 0 U2 2 PU WORLD SCIENTIFIC PUBL CO PTE LTD PI SINGAPORE PA 5 TOH TUCK LINK, SINGAPORE 596224, SINGAPORE SN 0217-9792 J9 INT J MOD PHYS B JI Int. J. Mod. Phys. B PD NOV 10 PY 2012 VL 26 IS 27-28 SI SI AR 1243004 DI 10.1142/S0217979212430047 PG 24 WC Physics, Applied; Physics, Condensed Matter; Physics, Mathematical SC Physics GA 008HD UT WOS:000308947100005 ER PT J AU Lenhart, JL Fischer, DA Chantawansri, TL Andzelm, JW AF Lenhart, Joseph L. Fischer, Daniel A. Chantawansri, Tanya L. Andzelm, Jan W. TI Surface Orientation of Polystyrene Based Polymers: Steric Effects from Pendant Groups on the Phenyl Ring SO LANGMUIR LA English DT Article ID ABSORPTION FINE-STRUCTURE; SELF-ASSEMBLED MONOLAYERS; GLASS-TRANSITION TEMPERATURE; SUM-FREQUENCY GENERATION; THIN-FILMS; THERMAL-PROPERTIES; MOLECULAR-ORIENTATION; STRUCTURE SPECTROSCOPY; TRIBLOCK COPOLYMERS; BLOCK-COPOLYMERS AB Near edge X-ray absorption fine structure (NEXAFS) coupled with molecular dynamics simulations were utilized to probe the orientation at the exposed surface of the polymer film for polystyrene type polymers With various pendant functional groups off the phenyl ring. For all the polymers, the surface was oriented so that the rings are nominally normal to the film surface and pointing outward from the surface. The magnitude of this orientation was small and dependent on the size of the pendant functional group. Bulky functional groups hindered the surface orientation, leading to nearly unoriented surfaces. Depth dependent NEXAFS measurements demonstrated that the surface orientation was localized near the interface. Molecular dynamics simulations showed that the phenyl rings were not oriented strongly around a particular "average tilt angle". In contrast, simulations demonstrate that the phenyl rings exhibit a broad distribution of tilt angles, and that changes in the tilt angle distribution with pendant functionality give rise to the observed NEXAFS response, The more oriented samples exhibit a higher probability of phenyl ring orientation at angles greater than 60 degrees relative to the plane of the films surface. C1 [Lenhart, Joseph L.; Chantawansri, Tanya L.; Andzelm, Jan W.] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. [Fischer, Daniel A.] NIST, Gaithersburg, MD 20899 USA. [Lenhart, Joseph L.] Sandia Natl Labs, Albuquerque, NM 87185 USA. RP Lenhart, JL (reprint author), USA, Res Lab, 4600 Deer Creek Loop, Aberdeen Proving Ground, MD 21005 USA. EM joseph.l.lenhart.civ@mail.mil RI Chantawansri, Tanya/N-3601-2013 FU United States Department of Energy's National Nuclear Security Administration [DE-AC04-94AL85000] FX We would also like to thank B. C. Rinderspacher for useful discussion. This work was initiated at Sandia National Laboratories by J.L.L. and is being continued at the United States Army Research Laboratory, Aberdeen Proving Ground, by J.L.L., T.L.C., and J.WA. Sandia is a multiprogram laboratory operated by Sandia Corporation, a Lockheed Martin Company, for the United States Department of Energy's National Nuclear Security Administration under Contract No. DE-AC04-94AL85000. Certain commercial equipment and materials are identified in this paper in order to specify adequately the experimental procedure. In no case does such identification imply recommendations by the Army Research Laboratory or does it imply that the material or equipment identified is necessarily the best available for this purpose. NR 84 TC 3 Z9 3 U1 0 U2 32 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0743-7463 J9 LANGMUIR JI Langmuir PD NOV 6 PY 2012 VL 28 IS 44 BP 15713 EP 15724 DI 10.1021/la303507e PG 12 WC Chemistry, Multidisciplinary; Chemistry, Physical; Materials Science, Multidisciplinary SC Chemistry; Materials Science GA 031TD UT WOS:000310664300034 PM 23078172 ER PT J AU Hu, LH Page, MA Sigstam, T Kohn, T Marinas, BJ Strathmann, TJ AF Hu, Lanhua Page, Martin A. Sigstam, Therese Kohn, Tamar Marinas, Benito J. Strathmann, Timothy J. TI Inactivation of Bacteriophage MS2 with Potassium Ferrate(VI) SO ENVIRONMENTAL SCIENCE & TECHNOLOGY LA English DT Article ID N-NITROSODIMETHYLAMINE NDMA; DISINFECTION BY-PRODUCTS; HYDROGEN-PEROXIDE; WATER-TREATMENT; COLIPHAGE MS2; NORWALK VIRUS; WASTE-WATER; OXIDATION; FE(VI); KINETICS AB Ferrate [Fe(VI); FeO42-] is an emerging oxidizing agent capable of controlling chemical and microbial water contaminants. Here, inactivation of MS2 coliphage by Fe(VI) was examined. The inactivation kinetics observed in individual batch experiments was well described by a Chick-Watson model with first order dependences on disinfectant and infective phage concentrations The inactivation rate constant k(i) at a Fe(VI) dose of 1.23 mgFe/L (pH 7.0, 25 degrees C) was 2.27(+/- 0.05) L/(mgFe x min), corresponding to 99.99% inactivation at a Ct of similar to 4 (mgFe x min)/L. Measured k(i) values were found to increase with increasing applied Fe(VI) dose (0.56-2.24 mgFe/L), increasing temperature (5-30 degrees C), and decreasing pH conditions (pH 6-11). The Fe(VI) dose effect suggested that an unidentified Fe byproduct also contributed to inactivation. Temperature dependence was characterized by an activation energy of 39(+/- 6) kJ mol(-1), and k(i), increased >50-fold when pH decreased from 11 to 6. The pH effect was quantitatively described by parallel reactions with HFeO4- and FeO42-. Mass spectrometry and qRT-PCR analyses demonstrated that both capsid protein and genome damage increased with the extent of inactivation, suggesting that both may contribute to phage inactivation. Capsid protein damage, localized in the two regions containing oxidant sensitive cysteine residues, and protein cleavage in one of the two regions may facilitate genome damage by increasing Fe(VI) access to the interior of the virion. C1 [Hu, Lanhua; Marinas, Benito J.; Strathmann, Timothy J.] Univ Illinois, Dept Civil & Environm Engn, Urbana, IL 61801 USA. [Hu, Lanhua; Marinas, Benito J.; Strathmann, Timothy J.] Univ Illinois, Ctr Adv Mat Purificat Water Syst, Urbana, IL 61801 USA. [Page, Martin A.] Construct Engn Res Lab, USACE Engineer Res & Dev Ctr, Champaign, IL 61822 USA. [Sigstam, Therese; Kohn, Tamar] Ecole Polytech Fed Lausanne EPFL, Environm Chem Lab, Sch Architecture Civil & Environm Engn ENAC, CH-1015 Lausanne, Switzerland. RP Strathmann, TJ (reprint author), Univ Illinois, Dept Civil & Environm Engn, Urbana, IL 61801 USA. EM strthmnn@illinois.edu RI Kohn, Tamar/H-1430-2011; Strathmann, Timothy/K-7606-2012 OI Kohn, Tamar/0000-0003-0395-6561; Strathmann, Timothy/0000-0002-7299-3115 FU National Science Foundation through WaterCAMPWS, a Science and Technology Center for Advanced Materials for the Purification of Water with Systems [CTS-0120978]; Division of Chemical, Bioengineering, Environmental, and Transport Systems [CBET-0746453]; Swiss National Science Foundation [CRSI22_127568/1] FX Support for authors at the University of Illinois was provided by the National Science Foundation through WaterCAMPWS, a Science and Technology Center for Advanced Materials for the Purification of Water with Systems (CTS-0120978) and the Division of Chemical, Bioengineering, Environmental, and Transport Systems (CBET-0746453). T.S. acknowledges support of a visiting professorship provided by EPFL. Support for authors at EPFL was provided by grant CRSI22_127568/1 of the Swiss National Science Foundation. NR 56 TC 23 Z9 24 U1 3 U2 57 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0013-936X J9 ENVIRON SCI TECHNOL JI Environ. Sci. Technol. PD NOV 6 PY 2012 VL 46 IS 21 BP 12079 EP 12087 DI 10.1021/es3031962 PG 9 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA 031TK UT WOS:000310665000072 PM 23030462 ER PT J AU Clifford, RJ Milillo, M Prestwood, J Quintero, R Zurawski, DV Kwak, YI Waterman, PE Lesho, EP Mc Gann, P AF Clifford, Robert J. Milillo, Michael Prestwood, Jackson Quintero, Reyes Zurawski, Daniel V. Kwak, Yoon I. Waterman, Paige E. Lesho, Emil P. Mc Gann, Patrick TI Detection of Bacterial 16S rRNA and Identification of Four Clinically Important Bacteria by Real-Time PCR SO PLOS ONE LA English DT Article ID RESISTANT STAPHYLOCOCCUS-AUREUS; ESCHERICHIA-COLI; PSEUDOMONAS-AERUGINOSA; KLEBSIELLA-PNEUMONIAE; ACINETOBACTER-BAUMANNII; MULTIPLEX PCR; VITEK 2; ENTEROBACTERIACEAE; GENES; DNA AB Within the paradigm of clinical infectious disease research, Acinetobacter baumannii, Escherichia coli, Klebsiella pneumoniae, and Pseudomonas aeruginosa represent the four most clinically relevant, and hence most extensively studied bacteria. Current culture-based methods for identifying these organisms are slow and cumbersome, and there is increasing need for more rapid and accurate molecular detection methods. Using bioinformatic tools, 962,279 bacterial 16S rRNA gene sequences were aligned, and regions of homology were selected to generate a set of real-time PCR primers that target 93.6% of all bacterial 16S rRNA sequences published to date. A set of four species-specific real-time PCR primer pairs were also designed, capable of detecting less than 100 genome copies of A. baumannii, E. coli, K. pneumoniae, and P. aeruginosa. All primers were tested for specificity in vitro against 50 species of Gram-positive and -negative bacteria. Additionally, the species-specific primers were tested against a panel of 200 clinical isolates of each species, randomly selected from a large repository of clinical isolates from diverse areas and sources. A comparison of culture and real-time PCR demonstrated 100% concordance. The primers were incorporated into a rapid assay capable of positive identification from plate or broth cultures in less than 90 minutes. Furthermore, our data demonstrate that current targets, such as the uidA gene in E. coli, are not suitable as species-specific genes due to sequence variation. The assay described herein is rapid, cost-effective and accurate, and can be easily incorporated into any research laboratory capable of real-time PCR. C1 [Clifford, Robert J.; Milillo, Michael; Prestwood, Jackson; Quintero, Reyes; Kwak, Yoon I.; Waterman, Paige E.; Lesho, Emil P.; Mc Gann, Patrick] Walter Reed Army Inst Res, Multidrug Resistant Organism Repository & Surveil, Silver Spring, MD 20910 USA. [Zurawski, Daniel V.] Walter Reed Army Inst Res, Dept Wound Infect, Silver Spring, MD USA. RP Mc Gann, P (reprint author), Walter Reed Army Inst Res, Multidrug Resistant Organism Repository & Surveil, Silver Spring, MD 20910 USA. EM patrick.mcgann@amedd.army.mil OI Zurawski, Daniel/0000-0002-7920-5601 NR 32 TC 35 Z9 41 U1 2 U2 48 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD NOV 6 PY 2012 VL 7 IS 11 AR e48558 DI 10.1371/journal.pone.0048558 PG 6 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 040IE UT WOS:000311315300038 PM 23139793 ER PT J AU Thorsley, D Klavins, E AF Thorsley, David Klavins, Eric TI Estimation and Discrimination of Stochastic Biochemical Circuits from Time-Lapse Microscopy Data SO PLOS ONE LA English DT Article ID DISCRETE-EVENT SYSTEMS; CHEMICAL-KINETICS; SIMULATION; NETWORKS; NOISE AB The ability of systems and synthetic biologists to observe the dynamics of cellular behavior is hampered by the limitations of the sensors, such as fluorescent proteins, available for use in time-lapse microscopy. In this paper, we propose a generalized solution to the problem of estimating the state of a stochastic chemical reaction network from limited sensor information generated by microscopy. We mathematically derive an observer structure for cells growing under time-lapse microscopy and incorporates the effects of cell division in order to estimate the dynamically-changing state of each cell in the colony. Furthermore, the observer can be used to discrimate between models by treating model indices as states whose values do not change with time. We derive necessary and sufficient conditions that specify when stochastic chemical reaction network models, interpreted as continuous-time Markov chains, can be distinguished from each other under both continual and periodic observation. We validate the performance of the observer on the Thattai-van Oudenaarden model of transcription and translation. The observer structure is most effective when the system model is well-parameterized, suggesting potential applications in synthetic biology where standardized biological parts are available. However, further research is necessary to develop computationally tractable approximations to the exact generalized solution presented here. C1 [Thorsley, David] USA, Dept Def Biotechnol High Performance Comp Softwar, Telemed & Adv Technol Res Ctr, Med Res & Mat Command, Ft Detrick, MD USA. [Klavins, Eric] Univ Washington, Dept Elect Engn, Seattle, WA 98195 USA. RP Thorsley, D (reprint author), USA, Dept Def Biotechnol High Performance Comp Softwar, Telemed & Adv Technol Res Ctr, Med Res & Mat Command, Ft Detrick, MD USA. EM thorsley@u.washington.edu FU AFOSR MURI (Air Force Office of Scientific Research Multidisciplinary University Research Initiative); NSF Award (National Science Foundation) [10002220] FX This research is partially supported by the 2006 AFOSR MURI (Air Force Office of Scientific Research Multidisciplinary University Research Initiative) award "High Confidence Design for Distributed Embedded Systems'' and NSF Award (National Science Foundation) #10002220, "Estimation and Observation of Stochastic Biochemical Networks.'' This work was performed while D. Thorsley was with the Department of Electrical Engineering, University of Washington, Seattle, USA. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 22 TC 1 Z9 1 U1 0 U2 4 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD NOV 6 PY 2012 VL 7 IS 11 AR e47151 DI 10.1371/journal.pone.0047151 PG 9 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 040IE UT WOS:000311315300006 PM 23139740 ER PT J AU Satyan, N Vasilyev, A Rakuljic, G White, JO Yariv, A AF Satyan, Naresh Vasilyev, Arseny Rakuljic, George White, Jeffrey O. Yariv, Amnon TI Phase-locking and coherent power combining of broadband linearly chirped optical waves SO OPTICS EXPRESS LA English DT Article ID STIMULATED BRILLOUIN-SCATTERING; YTTERBIUM FIBER AMPLIFIERS; LOCKED LOOP; SEMICONDUCTOR-LASERS; SBS-THRESHOLD; GENERATION; MICROWAVE; SYSTEM; TRANSMISSION; COMBINATION AB We propose, analyze and demonstrate the optoelectronic phase-locking of optical waves whose frequencies are chirped continuously and rapidly with time. The optical waves are derived from a common optoelectronic swept-frequency laser based on a semiconductor laser in a negative feedback loop, with a precisely linear frequency chirp of 400 GHz in 2 ms. In contrast to monochromatic waves, a differential delay between two linearly chirped optical waves results in a mutual frequency difference, and an acoustooptic frequency shifter is therefore used to phase-lock the two waves. We demonstrate and characterize homodyne and heterodyne optical phase-locked loops with rapidly chirped waves, and show the ability to precisely control the phase of the chirped optical waveform using a digital electronic oscillator. A loop bandwidth of similar to 60 kHz, and a residual phase error variance of < 0.01 rad(2) between the chirped waves is obtained. Further, we demonstrate the simultaneous phase-locking of two optical paths to a common master waveform, and the ability to electronically control the resultant two-element optical phased array. The results of this work enable coherent power combining of high-power fiber amplifiers-where a rapidly chirping seed laser reduces stimulated Brillouin scattering-and electronic beam steering of chirped optical waves. (c) 2012 Optical Society of America C1 [Satyan, Naresh; Vasilyev, Arseny; Yariv, Amnon] CALTECH, Dept Appl Phys & Mat Sci, Pasadena, CA 91125 USA. [Rakuljic, George] Telaris Inc, Santa Monica, CA 90403 USA. [White, Jeffrey O.] USA, Res Lab, Adelphi, MD 20783 USA. RP Satyan, N (reprint author), CALTECH, Dept Appl Phys & Mat Sci, 1200 E Calif Blvd 136-93, Pasadena, CA 91125 USA. EM naresh@caltech.edu FU U.S. Army Research Office [W911NF-11-2-0081]; High Energy Laser Joint Technology Office [11-SA-0405] FX The authors acknowledge the support of the U.S. Army Research Office (W911NF-11-2-0081) and the High Energy Laser Joint Technology Office (11-SA-0405). NR 33 TC 8 Z9 8 U1 1 U2 27 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1094-4087 J9 OPT EXPRESS JI Opt. Express PD NOV 5 PY 2012 VL 20 IS 23 BP 25213 EP 25227 DI 10.1364/OE.20.025213 PG 15 WC Optics SC Optics GA 040RJ UT WOS:000311340300030 PM 23187338 ER PT J AU Ter-Gabrielyan, N Fromzel, V Mu, X Meissner, H Dubinskii, M AF Ter-Gabrielyan, N. Fromzel, V. Mu, X. Meissner, H. Dubinskii, M. TI High efficiency, resonantly diode pumped, double-clad, Er:YAG-core, waveguide laser SO OPTICS EXPRESS LA English DT Article ID HIGH-AVERAGE-POWER; CRYSTAL FIBER; YAG LASER; GLASS AB We report on the highly efficient, resonantly diode-pumped Er:YAG-core, double-clad, all-crystalline eye-safe waveguide laser. A 500 x 500 mu m Er3+(1%):YAG single-crystalline core with an ultra low numerical aperture (NA) of similar to 0.02 was surrounded by a 700 x 700 mu m undoped single-crystalline YAG cladding. The entire Er:YAG/YAG core/clad structure was over-clad by transparent magnesium aluminum spinel (MgAl2O4) ceramic. The waveguide was continuously (CW) clad-pumped by a spectrally-narrowed, fiber-coupled InGaAsP/InP laser diode module at similar to 1532 nm. We achieved 25.4 W of output power at 1645 nm with a beam quality of M2 similar to 2.6. The achieved 56.6% slope efficiency with respect to the absorbed pump was derived by factoring out scattering loss of the pump light in the inner cladding. With a wavelength-selective cavity, the waveguide laser delivered similar to 8 W of output power at 1616.6 nm. To the best of our knowledge, it is the first reported laser experiment with a crystalline Er3+:YAG-core and a truly double-clad crystalline waveguide structure. (C) 2012 Optical Society of America C1 [Ter-Gabrielyan, N.; Fromzel, V.; Dubinskii, M.] USA, Res Lab, Adelphi, MD USA. [Mu, X.; Meissner, H.] ONYX Opt Inc, Dublin, CA 94658 USA. RP Ter-Gabrielyan, N (reprint author), USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD USA. EM nikolay.e.ter-gabrielyan.civ@mail.mil NR 16 TC 17 Z9 18 U1 1 U2 36 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1094-4087 J9 OPT EXPRESS JI Opt. Express PD NOV 5 PY 2012 VL 20 IS 23 BP 25554 EP 25561 DI 10.1364/OE.20.025554 PG 8 WC Optics SC Optics GA 040RJ UT WOS:000311340300065 PM 23187373 ER PT J AU Choi, YS Berry-Caban, C Stratman, R Fleming, JH AF Choi, Y. Sammy Berry-Caban, Cristobal Stratman, Rachel Fleming, Jill H. TI Prevalence of High Body Mass Index Among Children and Adolescents at a US Military Treatment Facility, 2008-2009 SO PREVENTING CHRONIC DISEASE LA English DT Article ID OBESITY; TRENDS AB We assessed the prevalence of high body mass index (BMI) in a large cohort of military children. We compared BMI data from electronic medical records of military children aged 2 to 18 years with BMI data from the National Health and Nutrition Examination Survey (NHANES). The 23, 7 7 8 military children studied were significantly less likely than the NHANES children to be overweight (2 7.1% vs 31.8%) or obese (11.9% vs 16.9%). Even though military parents are required to maintain fitness and weight standards, the absolute difference between military and civilian children was small. C1 [Choi, Y. Sammy; Berry-Caban, Cristobal; Fleming, Jill H.] Womack Army Med Ctr, Ft Bragg, NC 28310 USA. [Stratman, Rachel] Evans Army Community Hosp, Ft Carson, CO USA. RP Choi, YS (reprint author), Womack Army Med Ctr, Stop A,2817 Reilly Rd, Ft Bragg, NC 28310 USA. EM young.s.choi@us.army.mil NR 7 TC 0 Z9 0 U1 0 U2 1 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 1545-1151 J9 PREV CHRONIC DIS JI Prev. Chronic Dis. PD NOV PY 2012 VL 9 AR UNSP 120051 DI 10.5888/pcd9.120051 PG 5 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 173AV UT WOS:000321051300007 ER PT J AU Ahmad, F Fuhrmann, C Kerr, P Fairley, J Price, S Durst, B AF Ahmad, F. Fuhrmann, C. Kerr, P. Fairley, J. Price, S. Durst, B. TI Image enhancement through complex conduction coefficient modifications SO IET IMAGE PROCESSING LA English DT Article ID ANISOTROPIC DIFFUSION AB One important term in the diffusion equation applied to image processing is the conduction coefficient. It could be a real or complex function, depending on the chosen diffusion processes. A modification in the form of the application of filter convolution to the real-value conduction coefficient has been recommended for the improvement of the signal-to-noise ratio and the speed by which the diffusion is performed. In this study, the developments of the approximately circularly symmetric two-dimensional Lagrange filter and the Teager operator are presented. They are proposed here for the modification of the complex-value conduction coefficient for the improvement of the image diffusion process. Performance of the proposed modifications is evaluated through simulation and the use of three metrics. Experimental results suggest the validity and applicability of the proposed modifications. C1 [Ahmad, F.; Fuhrmann, C.; Kerr, P.] Tarleton State Univ, Dept Engn & Phys, Stephenville, TX USA. [Fairley, J.; Price, S.; Durst, B.] USA, Waterways Expt Stn, Engineer Res & Dev Ctr, Dept Army, Vicksburg, MS 39180 USA. RP Ahmad, F (reprint author), Tarleton State Univ, Dept Engn & Phys, Stephenville, TX USA. EM ahmad@tarleton.edu FU Department of the Army, Engineering Research and Development Center, ERDC, Vicksburg, Mississippi [W912HZ-08-C-0031]; Organized Research Grant, Tarleton State University FX This work was supported in part by the Department of the Army, Engineering Research and Development Center, ERDC, Vicksburg, Mississippi under contract W912HZ-08-C-0031 and the Organized Research Grant, Tarleton State University. The authors would like to extend their sincere thanks to Dr Larry N. Lynch, Chief, Engineering Systems and Materials Division, Geotechnical and Structures Laboratory (GSL) and Dr David W. Pittman, Director, GSL, ERDC. Permission was granted by the Director, GSL to publish this information. NR 27 TC 0 Z9 0 U1 0 U2 2 PU INST ENGINEERING TECHNOLOGY-IET PI HERTFORD PA MICHAEL FARADAY HOUSE SIX HILLS WAY STEVENAGE, HERTFORD SG1 2AY, ENGLAND SN 1751-9659 EI 1751-9667 J9 IET IMAGE PROCESS JI IET Image Process. PD NOV PY 2012 VL 6 IS 8 BP 1205 EP 1219 DI 10.1049/iet-ipr.2010.0384 PG 15 WC Computer Science, Artificial Intelligence; Engineering, Electrical & Electronic; Imaging Science & Photographic Technology SC Computer Science; Engineering; Imaging Science & Photographic Technology GA 134SI UT WOS:000318234300018 ER PT J AU Scales, RH AF Scales, Robert H. TI The Generals: American Military Command From World War II to Today SO FOREIGN AFFAIRS LA English DT Book Review C1 [Scales, Robert H.] USA, Washington, DC USA. [Scales, Robert H.] USA, War Coll, Washington, DC USA. NR 1 TC 1 Z9 1 U1 0 U2 0 PU COUNCIL FOREIGN RELAT IONS INC PI NEW YORK PA HAROLD PRATT HOUSE, 58 E 68TH ST, NEW YORK, NY 10065 USA SN 0015-7120 J9 FOREIGN AFF JI Foreign Aff. PD NOV-DEC PY 2012 VL 91 IS 6 BP 137 EP 143 PG 7 WC International Relations SC International Relations GA 145NM UT WOS:000319023700014 ER PT J AU Kane, JD Steinbach, TJ Sturdivant, RX Burks, RE AF Kane, Julie D. Steinbach, Thomas J. Sturdivant, Rodney X. Burks, Robert E. TI Sex-Associated Effects on Hematologic and Serum Chemistry Analytes in Sand Rats (Psammomys obesus) SO JOURNAL OF THE AMERICAN ASSOCIATION FOR LABORATORY ANIMAL SCIENCE LA English DT Article ID CUTANEOUS LEISHMANIASIS; DISK DEGENERATION; DIABETES-MELLITUS; SPONDYLOSIS; PARAMETERS; RODENTS; JORDAN; LIGHT; MODEL AB We sought to determine whether sex had a significant effect on the hematologic and serum chemistry analytes in adult sand rats (Psammomys obesus) maintained under normal laboratory conditions. According to the few data available for this species, we hypothesized that levels of hematologic and serum chemistry analytes would not differ significantly between clinically normal male and female sand rats. Data analysis revealed several significant differences in hematologic parameters between male and female sand rats but none for serum biochemistry analytes. The following hematologic parameters were greater in male than in female sand rats: RBC count, hemoglobin, hematocrit, red cell hemoglobin content, and percentage monocytes. Red cell distribution width, hemoglobin distribution width, mean platelet volume, and percentage lymphocytes were greater in female than in male sand rats. The sex of adult sand rats is a source of variation that must be considered in terms of clinical and research data. The data presented here likely will prove useful in the veterinary medical management of sand rat colonies and provide baseline hematologic and serum chemistry analyte information for researchers wishing to use this species. C1 [Kane, Julie D.; Steinbach, Thomas J.] Walter Reed Army Inst Res, Vet Serv Program, Silver Spring, MD 20910 USA. [Sturdivant, Rodney X.] US Mil Acad, Dept Math Sci, West Point, NY 10996 USA. [Burks, Robert E.] USN, Postgrad Sch, Dept Operat Res, Monterey, CA USA. RP Kane, JD (reprint author), Walter Reed Army Inst Res, Vet Serv Program, Silver Spring, MD 20910 USA. EM julie.d.kane@us.army.mil NR 39 TC 1 Z9 1 U1 0 U2 2 PU AMER ASSOC LABORATORY ANIMAL SCIENCE PI MEMPHIS PA 9190 CRESTWYN HILLS DR, MEMPHIS, TN 38125 USA SN 1559-6109 J9 J AM ASSOC LAB ANIM JI J. Amer. Assoc. Lab. Anim. Sci. PD NOV PY 2012 VL 51 IS 6 BP 769 EP 774 PG 6 WC Veterinary Sciences; Zoology SC Veterinary Sciences; Zoology GA 098PL UT WOS:000315561100002 PM 23294882 ER PT J AU Krakauer, T AF Krakauer, Teresa TI PI3K/Akt/mTOR, a Pathway Less Recognized for Staphylococcal Superantigen-Induced Toxicity SO TOXINS LA English DT Review DE staphylococcal superantigens; inflammatory cytokines; signaling pathways; PI3K; Akt; mTOR; therapeutics ID SHOCK-SYNDROME TOXIN-1; TUMOR-NECROSIS-FACTOR; T-CELL-ACTIVATION; COMPLEX CLASS-II; NF-KAPPA-B; RECEPTOR SIGNAL-TRANSDUCTION; EXOTOXIN-INDUCED CYTOKINES; NUCLEAR IMPORT INHIBITOR; BLOOD MONONUCLEAR-CELLS; INDUCED LETHAL SHOCK AB Immunostimulating staphylococcal enterotoxin B (SEB) and related superantigenic toxins cause diseases in humans and laboratory animals by activating cells of the immune system. These toxins bind directly to the major histocompatibility complex (MHC) class II molecules on antigen-presenting cells and specific V beta regions of T-cell receptors (TCR), resulting in hyperactivation of both T lymphocytes and monocytes/macrophages. Activated host cells produce excessive amounts of proinflammatory cytokines and chemokines, especially tumor necrosis factor alpha, interleukin 1 (IL-1), IL-2, interferon gamma (IFN gamma), and macrophage chemoattractant protein 1 causing clinical symptoms of fever, hypotension, and shock. The well-explored signal transduction pathways for SEB-induced toxicity downstream from TCR/MHC ligation and interaction of cell surface co-stimulatory molecules include the mitogen-activated protein kinase cascades and cytokine receptor signaling, culminating in NF kappa B activation. Independently, IL-2, IFN gamma, and chemokines from activated T cells signal via the phosphoinositide 3-kinase (PI3K), the serine/threonine kinases, Akt and mammalian target of rapamycin (mTOR) pathways. This article reviews the signaling molecules induced by superantigens in the activation of PI3K/Akt/mTOR pathways leading to staphylococcal superantigen-induced toxicity and updates potential therapeutics against superantigens. C1 USA, Med Res Inst Infect Dis, Dept Immunol, Integrated Toxicol Div, Frederick, MD 21702 USA. RP Krakauer, T (reprint author), USA, Med Res Inst Infect Dis, Dept Immunol, Integrated Toxicol Div, Frederick, MD 21702 USA. EM teresa.krakauer@us.army.mil NR 146 TC 5 Z9 5 U1 0 U2 9 PU MDPI AG PI BASEL PA POSTFACH, CH-4005 BASEL, SWITZERLAND SN 2072-6651 J9 TOXINS JI Toxins PD NOV PY 2012 VL 4 IS 11 BP 1343 EP 1366 DI 10.3390/toxins4111343 PG 24 WC Toxicology SC Toxicology GA 096LV UT WOS:000315406500020 PM 23202320 ER PT J AU Miranda, LE Aycock, JN Killgore, KJ AF Miranda, L. E. Aycock, J. N. Killgore, K. J. TI A Direct-Gradient Multivariate Index of Biotic Condition SO TRANSACTIONS OF THE AMERICAN FISHERIES SOCIETY LA English DT Article ID MULTIMETRIC INDEXES; REDUNDANCY ANALYSIS; INTEGRITY; STREAMS; PERFORMANCE; MANAGEMENT; REGRESSION; METRICS; SCALE; OXBOW AB Multimetric indexes constructed by summing metric scores have been criticized despite many of their merits. A leading criticism is the potential for investigator bias involved in metric selection and scoring. Often there is a large number of competing metrics equally well correlated with environmental stressors, requiring a judgment call by the investigator to select the most suitable metrics to include in the index and how to score them. Data-driven procedures for multimetric index formulation published during the last decade have reduced this limitation, yet apprehension remains. Multivariate approaches that select metrics with statistical algorithms may reduce the level of investigator bias and alleviate a weakness of multimetric indexes. We investigated the suitability of a direct-gradient multivariate procedure to derive an index of biotic condition for fish assemblages in oxbow lakes in the Lower Mississippi Alluvial Valley. Although this multivariate procedure also requires that the investigator identify a set of suitable metrics potentially associated with a set of environmental stressors, it is different from multimetric procedures because it limits investigator judgment in selecting a subset of biotic metrics to include in the index and because it produces metric weights suitable for computation of index scores. The procedure, applied to a sample of 35 competing biotic metrics measured at 50 oxbow lakes distributed over a wide geographical region in the Lower Mississippi Alluvial Valley, selected 11 metrics that adequately indexed the biotic condition of five test lakes. Because the multivariate index includes only metrics that explain the maximum variability in the stressor variables rather than a balanced set of metrics chosen to reflect various fish assemblage attributes, it is fundamentally different from multimetric indexes of biotic integrity with advantages and disadvantages. As such, it provides an alternative to multimetric procedures. C1 [Miranda, L. E.] US Geol Survey, Mississippi Cooperat Fish & Wildlife Res Unit, Mississippi State, MS 39762 USA. [Aycock, J. N.] Dept Wildlife Fisheries & Aquaculture, Mississippi State, MS 39762 USA. [Killgore, K. J.] USA, Corps Engineers, Engn Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Miranda, LE (reprint author), US Geol Survey, Mississippi Cooperat Fish & Wildlife Res Unit, POB 9691, Mississippi State, MS 39762 USA. EM smiranda@usgs.gov FU Vicksburg District of the U.S. Army Corps of Engineers; Mississippi State University; U.S. Geological Survey Mississippi Cooperative Fish and Wildlife Research Unit; Vicksburg District FX This research was funded by the Vicksburg District of the U.S. Army Corps of Engineers, Mississippi State University, and the U.S. Geological Survey Mississippi Cooperative Fish and Wildlife Research Unit. We thank Kent Parrish and Dave Johnson, Vicksburg District, for providing funding and technical advice; Ted Alfermann, Dan Dembkowski, Seiji Miyazono, and Chris Steffen for help with field work; and Tom Kwak, Luiz Gomes, Sam Stribling, Chris Millard, and John Van Sickle for helpful reviews. Any use of trade, product, or firm names is for descriptive purposes only and does not imply endorsement by the U. S. Government. Permission was granted by the Chief of Engineers to publish this document. NR 40 TC 1 Z9 1 U1 1 U2 11 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA SN 0002-8487 J9 T AM FISH SOC JI Trans. Am. Fish. Soc. PD NOV 1 PY 2012 VL 141 IS 6 BP 1637 EP 1648 DI 10.1080/00028487.2012.717519 PG 12 WC Fisheries SC Fisheries GA 093TU UT WOS:000315216000019 ER PT J AU Jeong, CK Panchang, V Demirbilek, Z AF Jeong, Chan Kwon Panchang, Vijay Demirbilek, Zeki TI Parametric Adjustments to the Rankine Vortex Wind Model for Gulf of Mexico Hurricanes SO JOURNAL OF OFFSHORE MECHANICS AND ARCTIC ENGINEERING-TRANSACTIONS OF THE ASME LA English DT Article ID 44-YEAR WAVE HINDCAST; FIELDS; PROFILES; LEVEL; COAST; SURGE AB Parametric wind models are often used to reconstruct hurricane wind fields from a limited set of hurricane parameters. Application of the Rankine Vortex and other models used in forecasting Gulf of Mexico hurricanes show considerable differences between the resulting wind speeds and data. The differences are used to guide the development of adjustment factors to improve the wind fields resulting from the Rankine Vortex model. The corrected model shows a significant improvement in the shape, size, and wind speed contours for 14 out of 17 hurricanes examined. The effect on wave fields resulting from the original and modified wind fields are on the order of 4 m, which is important for the estimation of extreme wave statistics. [DOI: 10.1115/1.4006148] C1 [Jeong, Chan Kwon] Dockwise USA, Houston, TX 77084 USA. [Panchang, Vijay] Texas A&M Univ, Maritime Syst Engn Dept, Galveston, TX 77553 USA. [Demirbilek, Zeki] USA, Engn Res & Dev Ctr, Coastal & Hydraul Lab, Vicksburg, MS 39180 USA. RP Demirbilek, Z (reprint author), USA, Engn Res & Dev Ctr, Coastal & Hydraul Lab, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM chankwon.jeong@gmail.com; panchanv@tamug.edu; zeki.demirbilek@usace.army.mil NR 37 TC 4 Z9 4 U1 0 U2 4 PU ASME PI NEW YORK PA TWO PARK AVE, NEW YORK, NY 10016-5990 USA SN 0892-7219 J9 J OFFSHORE MECH ARCT JI J. Offshore Mech. Arct. Eng. Trans. ASME PD NOV PY 2012 VL 134 IS 4 AR 041102 DI 10.1115/1.4006148 PG 17 WC Engineering, Ocean; Engineering, Mechanical SC Engineering GA 087NE UT WOS:000314767600002 ER PT J AU Mentzer, MA Gurganus, JC AF Mentzer, Mark A. Gurganus, James C. TI Design and analysis of a cineradiographic x-ray imaging system for capturing dynamic deformation of materials SO OPTICAL ENGINEERING LA English DT Article DE flash x-ray; cineradiography; x-ray imaging; 3-D x-ray; algebraic reconstruction ID RECONSTRUCTION AB Innovations in x-ray imaging are described to evaluate spatial and temporal dissipation and relaxation dynamics in materials. A system is constructed employing five sets of image planes orthogonal to the target, such that the centerline image-plane orthogonal axes are coplanar. Variable pulser firing sequences flash five x-ray tubes, capturing temporal sequences of interest, and controlled coincident firing sequences characterize ballistic impact events in three dimensions. (C) 2012 Society of Photo-Optical Instrumentation Engineers (SPIE). [DOI: 10.1117/1.OE.51.11.116501] C1 [Mentzer, Mark A.; Gurganus, James C.] USA, Ballist Res Lab, Survivabil Lethal Anal Directorate, Aberdeen Proving Ground, MD 21005 USA. RP Mentzer, MA (reprint author), USA, Ballist Res Lab, Survivabil Lethal Anal Directorate, Aberdeen Proving Ground, MD 21005 USA. EM markmentzer@hotmail.com NR 24 TC 0 Z9 0 U1 1 U2 7 PU SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98225 USA SN 0091-3286 EI 1560-2303 J9 OPT ENG JI Opt. Eng. PD NOV PY 2012 VL 51 IS 11 AR 116501 DI 10.1117/1.OE.51.11.116501 PG 10 WC Optics SC Optics GA 083KJ UT WOS:000314462100052 ER PT J AU Trope, RL AF Trope, Roland L. TI "There's No App for That": Calibrating Cybersecurity Safeguards and Disclosures SO BUSINESS LAWYER LA English DT Article C1 [Trope, Roland L.] Trope & Schramm LLP, New York Off, New York, NY USA. [Trope, Roland L.] US Mil Acad, Dept Law, West Point, NY USA. RP Trope, RL (reprint author), Trope & Schramm LLP, New York Off, New York, NY USA. EM rltrope@tropelaw.com NR 14 TC 4 Z9 4 U1 0 U2 1 PU AMER BAR ASSOC, ADMINISTRATIVE LAW & REGULATORY PRACTICE SECTION PI CHICAGO PA 321 N CLARK ST, CHICAGO, IL 60610 USA SN 0007-6899 J9 BUS LAWYER JI Bus. Lawyer PD NOV PY 2012 VL 68 IS 1 BP 183 EP 195 PG 13 WC Law SC Government & Law GA 069ZX UT WOS:000313476700010 ER PT J AU Taneja, S Akcamete, A Akinci, B Garrett, JH Soibelman, L East, EW AF Taneja, Saurabh Akcamete, Asli Akinci, Burcu Garrett, James H., Jr. Soibelman, Lucio East, E. William TI Analysis of Three Indoor Localization Technologies for Supporting Operations and Maintenance Field Tasks SO JOURNAL OF COMPUTING IN CIVIL ENGINEERING LA English DT Article DE Maintenance; Automatic identification system; Field tests; Information management; Data collection; Localization ID FREQUENCY IDENTIFICATION TECHNOLOGY; TRACKING; SYSTEM; CONSTRUCTION AB Locating building components that need to be worked on during maintenance tasks is critical for timely repair of the component and mitigation of the damage. The process of locating a component or a person in a facility is called indoor localization. The objective of this research study is to analyze the feasibility of three indoor localization technologies for supporting operations and maintenance (O&M) field tasks; namely, wireless local area network (WLAN), radio frequency identification (RFID) tags, and inertial measurement units (IMU). These technologies have been selected on the basis of the requirements of the localization needed for supporting O&M field activities. A previous work has been extended, which tested RFID-based locations in an indoor environment, by testing the three selected technologies in the same test bed and using the same hypothesis and fingerprinting approach developed in the previous work. The two main motivations behind using the same test bed and same approach are to have the same baseline to evaluate the performance of the three technologies and to evaluate the performance of RFID-based localization over longer periods. The results in the present study show that RFID-based localization suffers from a decrease in signal strength levels over several years, and that WLAN-based localization suffers from variations in signal strength. They also show that IMU-based localization suffers from drift in the sensors of IMU. Prior knowledge of the layout of a facility can improve the performance of WLAN, RFID, and IMU-based localization. DOI:10.1061/(ASCE)CP.1943-5487.0000177. (C) 2012 American Society of Civil Engineers. C1 [Taneja, Saurabh; Akcamete, Asli; Akinci, Burcu; Garrett, James H., Jr.; Soibelman, Lucio] Carnegie Mellon Univ, Dept Civil & Environm Engn, Pittsburgh, PA 15213 USA. [East, E. William] Construct Engineer Res Lab, Engineer Res & Dev Ctr, Champaign, IL 61826 USA. RP Taneja, S (reprint author), Carnegie Mellon Univ, Dept Civil & Environm Engn, 121 Porter Hall,5000 Forbes Ave, Pittsburgh, PA 15213 USA. EM staneja@andrew.cmu.edu; asli@cmu.edu; bakinci@andrew.cmu.edu; garrett@cmu.edu; lucio@andrew.cmu.edu; bill.east@us.army.mil FU Engineer Research and Development Center (ERDC) of the U.S. Army Corps of Engineers (USACE) FX This project was funded by the Engineer Research and Development Center (ERDC) of the U.S. Army Corps of Engineers (USACE). We also acknowledge the work done by Pradhan et al. (2009b), which formed the basis of the research performed in this study. NR 60 TC 12 Z9 13 U1 0 U2 26 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 0887-3801 J9 J COMPUT CIVIL ENG JI J. Comput. Civil. Eng. PD NOV-DEC PY 2012 VL 26 IS 6 BP 708 EP 719 DI 10.1061/(ASCE)CP.1943-5487.0000177 PG 12 WC Computer Science, Interdisciplinary Applications; Engineering, Civil SC Computer Science; Engineering GA 067KL UT WOS:000313292800003 ER PT J AU Saito, L Surbeck, CQ Langsdale, S Bourget, E Wride, D AF Saito, Laurel Surbeck, Cristiane Queiroz Langsdale, Stacy Bourget, Elizabeth Wride, Derek TI Engaging International Perspectives through EWRI for a Global Profession SO JOURNAL OF WATER RESOURCES PLANNING AND MANAGEMENT-ASCE LA English DT Editorial Material C1 [Saito, Laurel] Univ Nevada, Dept Nat Resources & Environm Sci, Reno, NV 89557 USA. [Saito, Laurel] Univ Nevada, Grad Program Hydrol Sci, Reno, NV 89557 USA. [Surbeck, Cristiane Queiroz] Univ Mississippi, Dept Civil Engn, University, MS 38677 USA. [Langsdale, Stacy; Bourget, Elizabeth] USA, Engn Inst Water Resources, Alexandria, VA 22315 USA. [Wride, Derek] CDM Smith Inc, Columbus, OH 43240 USA. RP Saito, L (reprint author), Univ Nevada, Dept Nat Resources & Environm Sci, Reno, NV 89557 USA. EM lsaito@cabnr.unr.edu; wridedd@cdmsmith.com RI Saito, Laurel/E-3096-2010 OI Saito, Laurel/0000-0003-3617-3133 NR 2 TC 0 Z9 0 U1 0 U2 0 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 0733-9496 J9 J WATER RES PL-ASCE JI J. Water Resour. Plan. Manage.-ASCE PD NOV-DEC PY 2012 VL 138 IS 6 BP 588 EP 589 DI 10.1061/(ASCE)WR.1943-5452.0000293 PG 2 WC Engineering, Civil; Water Resources SC Engineering; Water Resources GA 068IJ UT WOS:000313359600001 ER PT J AU Adler, M Deshpande, SS Apland, JP Murray, B Borrell, A AF Adler, Michael Deshpande, Sharad S. Apland, James P. Murray, Bridget Borrell, Andrew TI Reversal of BoNT/A-mediated inhibition of muscle paralysis by 3,4-diaminopyridine and roscovitine in mouse phrenic nerve-hemidiaphragm preparations SO NEUROCHEMISTRY INTERNATIONAL LA English DT Article DE Botulinum neurotoxin; 3,4-Diaminopyridine; Roscovitine; Acetylcholine; Mouse; Diaphragm muscle; Aminopyridine; Potassium channel blocker; Calcium channel agonist; Bioterrorism ID DEPENDENT KINASE INHIBITOR; BOTULINUM NEUROTOXIN LIGHT; MULTIPLE-SCLEROSIS; R-ROSCOVITINE; TOXIN; GUANIDINE; CHANNELS; RELEASE; RAT; 4-AMINOPYRIDINE AB Botulinum neurotoxins (BoNTs) comprise a family of neurotoxic proteins synthesized by anaerobic bacteria of the genus Clostridium. Each neurotoxin consists of two polypeptide chains: a 100 kDa heavy chain, responsible for binding and internalization into the nerve terminal of cholinergic motoneurons and a 50 kDa light chain that mediates cleavage of specific synaptic proteins in the host nerve terminal. Exposure to BoNT leads to cessation of voltage- and Ca2+-dependent acetylcholine (ACh) release, resulting in flaccid paralysis which may be protracted and potentially fatal. There are no approved therapies for BoNT intoxication once symptoms appear, and specific inhibitors of the light chain developed to date have not been able to reverse the consequences of BoNT intoxication. An alternative approach for treatment of botulism is to focus on compounds that act by enhancing ACh release. To this end, we examined the action of the K+ channel blocker 3,4-diaminopyridine (3,4-DAP) in isolated mouse hemidiaphragm muscles intoxicated with 5 pM BoNT/A. 3,4-DAP restored tension within 1-3 min of application, and was effective even in totally paralyzed muscle. The Ca2+ channel activator (R)roscovitine (Ros) potentiated the action of 3,4-DAP, allowing for use of lower concentrations of the K+ channel blocker. In the absence of 3,4-DAP, Ros was unable to augment tension in BoNT/A-intoxicated muscle. This is the first report demonstrating the efficacy of the combination of 3,4-DAP and Ros for the potential treatment of BoNT/A-mediated muscle paralysis. Published by Elsevier Ltd. C1 [Adler, Michael; Deshpande, Sharad S.; Apland, James P.; Murray, Bridget; Borrell, Andrew] USA, Med Res Inst Chem Def, Neurobehav Toxicol Branch, Analyt Toxicol Div, Aberdeen Proving Ground, MD 21010 USA. [Adler, Michael] Univ Massachusetts, Dept Chem & Biochem, Dartmouth, MA 02747 USA. RP Adler, M (reprint author), USA, Med Res Inst Chem Def, Neurobehav Toxicol Branch, Analyt Toxicol Div, 3100 Ricketts Point Rd, Aberdeen Proving Ground, MD 21010 USA. EM michael.adler2@us.army.mil FU Defense Threat Reduction Agency-Joint Science and Technology Office, Medical S T Division FX The views expressed are those of the authors and do not reflect the official policy of the U.S. Department of Army, Department of Defense, or U.S. Government. The experimental protocol was approved by the animal Care and Use Committee at the United States Army Medical Research Institute of Chemical Defense, and all procedures were conducted in accordance with the principles stated in the Guide for the Care and Use of Laboratory Animals and the Animal Welfare Act of 1966 (P.L. 89-544), as amended. This research was supported by the Defense Threat Reduction Agency-Joint Science and Technology Office, Medical S & T Division. NR 60 TC 8 Z9 8 U1 0 U2 10 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0197-0186 J9 NEUROCHEM INT JI Neurochem. Int. PD NOV PY 2012 VL 61 IS 6 BP 866 EP 873 DI 10.1016/j.neuint.2012.07.015 PG 8 WC Biochemistry & Molecular Biology; Neurosciences SC Biochemistry & Molecular Biology; Neurosciences & Neurology GA 068NY UT WOS:000313374600010 PM 22841859 ER PT J AU Xydakis, MS Ling, GSF Mulligan, LP Olsen, CH Dorlac, WC AF Xydakis, Michael S. Ling, Geoffrey S. F. Mulligan, Lisa P. Olsen, Cara H. Dorlac, Warren C. TI Epidemiologic aspects of traumatic brain injury in acute combat casualties at a major military medical center: A cohort study SO ANNALS OF NEUROLOGY LA English DT Article ID MINOR HEAD-INJURY; GLASGOW COMA SCALE; SEVERITY SCORE; IRAQ; CONSCIOUSNESS; VETERANS; NEUROPSYCHOLOGY; AFGHANISTAN; CONCUSSION; SYMPTOMS AB Objective: From the ongoing military conflicts in Iraq and Afghanistan, an understanding of the neuroepidemiology of traumatic brain injury (TBI) has emerged as requisite for further advancements in neurocombat casualty care. This study reports population-specific incidence data and investigates TBI identification and grading criteria with emphasis on the role of loss of consciousness (LOC) in the diagnostic rubric. Methods: This is a cohort study of all consecutive troops acutely injured during combat operationssustaining body-wide injuries sufficient to require immediate stateside evacuationand admitted sequentially to our medical center during a 2-year period. A prospective exploration of the TBI identification and grading system was performed in a homogeneous population of blast-injured polytrauma inpatients. Results: TBI incidence was 54.3%. Structural neuroimaging abnormalities were identified in 14.0%. Higher Injury Severity Score (ISS) was associated with abnormal neuroimaging, longer length of stay (LOS), and elevated TBI statusprimarily based on autobiographical LOC. Mild TBI patients had normal neuroimaging, higher ISS, and comparable LOS to TBI-negative patients. Patients who reported LOC had a lower incidence of abnormal neuroimaging. Interpretation: This study demonstrates that the methodology used to assign the diagnosis of a mild TBI in troops with complex combat-related injuries is crucial to an accurate accounting. The detection of incipient mild TBI, based on an identification system that utilizes LOC as the principal diagnostic criterion to discern among patients with outcomes of interest, misclassifies patients whose LOC may not reflect actual brain injury. Attempts to identify high-risk battlefield casualties within the current point-of-injury mild TBI case definition, which favors high sensitivity, will be at the expense of specificity. ANN NEUROL 2012;72:673681 C1 [Xydakis, Michael S.] Uniformed Serv Univ Hlth Sci, Dept Surg, Traumat Brain Injury Surg Res Program, Div Otolaryngol, Bethesda, MD 20814 USA. [Xydakis, Michael S.; Ling, Geoffrey S. F.; Mulligan, Lisa P.] Uniformed Serv Univ Hlth Sci, Walter Reed Army Med Ctr, Bethesda, MD 20814 USA. [Ling, Geoffrey S. F.] Uniformed Serv Univ Hlth Sci, Dept Neurol, Bethesda, MD 20814 USA. [Mulligan, Lisa P.] Uniformed Serv Univ Hlth Sci, Dept Neurosurg, Bethesda, MD 20814 USA. [Olsen, Cara H.] Uniformed Serv Univ Hlth Sci, Dept Prevent Med & Biometr, Bethesda, MD 20814 USA. RP Xydakis, MS (reprint author), Uniformed Serv Univ Hlth Sci, Walter Reed Natl Mil Med Ctr, Bethesda, MD 20814 USA. EM Michael.Xydakis@usuhs.edu FU Sanofi; Bristol-Myers; Squibb FX G.S.F.L.: speaking fees, Sanofi, Bristol-Myers, Squibb (not active); stock/stock options, Merck. NR 39 TC 23 Z9 23 U1 1 U2 9 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0364-5134 J9 ANN NEUROL JI Ann. Neurol. PD NOV PY 2012 VL 72 IS 5 BP 673 EP 681 DI 10.1002/ana.23757 PG 9 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA 062RV UT WOS:000312940300007 PM 23060246 ER PT J AU Holladay, JP Nisanian, M Williams, S Tuckfield, RC Kerr, R Jarrett, T Tannenbaum, L Holladay, SD Sharma, A Gogal, RM AF Holladay, Jeremy P. Nisanian, Mandy Williams, Susan Tuckfield, R. Cary Kerr, Richard Jarrett, Timothy Tannenbaum, Lawrence Holladay, Steven D. Sharma, Ajay Gogal, Robert M., Jr. TI Dosing of adult pigeons with as little as one #9 lead pellet caused severe delta-ALAD depression, suggesting potential adverse effects in wild populations SO ECOTOXICOLOGY LA English DT Article DE Lead; Avian; Ventriculus; Retention; delta-ALAD ID COEUR-DALENE RIVER; BLOOD CHARACTERISTICS; RISK-ASSESSMENT; MOURNING DOVES; CANADA GEESE; ACID; CALCIUM; BIRDS; SHOT; RETENTION AB Avian wildlife species commonly ingest lead (Pb) spent shot or bullet fragments as grit or mistakenly as food. In previous studies in our laboratory and others, the toxicity varied based on the diet as well as type and quantity of Pb ingested. In the current study, domestic pigeons were gavaged with 1, 2, or 3 Pb pellets and then followed with weekly radiographs and blood physiologic endpoints for 28 days. Pellet retention decreased by roughly 50 % per week as pellets were either absorbed or excreted, except for week 4 where pellet number no longer was diminished. Size of retained pellets visually decreased over retention time. Birds dosed with a single #9 pellet showed mean blood Pb levels over 80 times higher than those of the controls, verifying Pb pellet absorption from the gut. A single Pb pellet also reduced plasma delta-aminolevulinic acid dehydratase (delta-ALAD) activity by over 80 % compared to controls, suggesting the potential for population injury in Pb pellet-exposed pigeons. C1 [Holladay, Jeremy P.; Nisanian, Mandy; Kerr, Richard; Jarrett, Timothy; Holladay, Steven D.; Sharma, Ajay; Gogal, Robert M., Jr.] Univ Georgia, Coll Vet Med, Dept Biosci & Diagnost Imaging, Athens, GA 30602 USA. [Williams, Susan] Univ Georgia, Coll Vet Med, Dept Populat Hlth, Poultry Diagnost & Res Ctr, Athens, GA 30602 USA. [Tuckfield, R. Cary] Univ Georgia, Savannah River Ecol Lab, Athens, GA 30622 USA. [Tannenbaum, Lawrence] USA, Inst Publ Hlth, Aberdeen, MD 21010 USA. RP Gogal, RM (reprint author), Univ Georgia, Coll Vet Med, Dept Biosci & Diagnost Imaging, Athens, GA 30602 USA. EM rgogal@uga.edu FU Department of Defense, U.S. Army Institute for Public Health FX We wish to thank Mr. Danny Joe Humphrey of Color Pigeons for his advice on husbandry of the pigeons. We also wish to thank Dr. Carla Jarrett for assistance with bird restraint during the radiographs. We also wish to thank Mr. Michael Mottsinger and Mr. Brent Lovern of the Poultry Diagnostic Research Center at University of Georgia for care and maintenance of the birds. The study was funded by a grant from the Department of Defense, U.S. Army Institute for Public Health. NR 29 TC 4 Z9 4 U1 1 U2 27 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0963-9292 J9 ECOTOXICOLOGY JI Ecotoxicology PD NOV PY 2012 VL 21 IS 8 BP 2331 EP 2337 DI 10.1007/s10646-012-0989-x PG 7 WC Ecology; Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA 058WG UT WOS:000312664900023 PM 22903291 ER PT J AU McFarland, CA Talent, LG Quinn, MJ Bazar, MA Wilbanks, MS Nisanian, M Gogal, RM Johnson, MS Perkins, EJ Gust, KA AF McFarland, Craig A. Talent, Larry G. Quinn, Michael J., Jr. Bazar, Matthew A. Wilbanks, Mitchell S. Nisanian, Mandana Gogal, Robert M., Jr. Johnson, Mark S. Perkins, Edward J. Gust, Kurt A. TI Multiple environmental stressors elicit complex interactive effects in the western fence lizard (Sceloporus occidentalis) SO ECOTOXICOLOGY LA English DT Article DE Multiple stressors; Ecotoxicology; Reptile toxicology; Malaria; Munitions constituents; Hormesis ID PARASITE PLASMODIUM-MEXICANUM; BOBWHITE COLINUS-VIRGINIANUS; GAMETOCYTE SEX-RATIO; NORTHERN BOBWHITE; MALARIA PARASITE; NITROAROMATIC COMPOUNDS; CLONAL DIVERSITY; BODY CONDITION; ORAL TOXICITY; 2,4,6-TRINITROTOLUENE AB Evaluation of multiple-stressor effects stemming from habitat degradation, climate change, and exposure to chemical contaminants is crucial for addressing challenges to ecological and environmental health. To assess the effects of multiple stressors in an understudied taxon, the western fence lizard (Sceloporus occidentalis) was used to characterize the individual and combined effects of food limitation, exposure to the munitions constituent 2,4,6-trinitrotoluene (TNT), and Plasmodium mexicanum (lizard malaria) infection. Three experimental assays were conducted including: Experiment I-TNT x Food Limitation, Experiment II-Food Limitation x Malaria Infection, and Experiment III-TNT x Malaria Infection. All experiments had a 30 day duration, the malaria treatment included infected and non infected control lizards, food limitation treatments included an ad libitum control and at least one reduced food ration and TNT exposures consisting of daily oral doses of corn oil control or a corn oil-TNT suspension at 5, 10, 20, 40 mg/kg/day. The individual stressors caused a variety of effects including: reduced feeding, reduced testes mass, anemia, increased white blood cell (WBC) concentrations and increased mass of liver, kidney and spleen in TNT exposures; reduced cholesterol, WBC concentrations and whole body, testes and inguinal fat weights given food limitation; and increased WBC concentrations and spleen weights as well as decreased cholesterol and testes mass in malaria infected lizards. Additive and interactive effects were found among certain stressor combinations including elimination of TNT-induced hormesis for growth under food limitation. Ultimately, our study indicates the potential for effects modulation when environmental stressors are combined. C1 [McFarland, Craig A.; Quinn, Michael J., Jr.; Bazar, Matthew A.; Johnson, Mark S.] USA, Hlth Effects Res Program, Inst Publ Hlth, Edgewood Area, Aberdeen Proving Ground, MD 21010 USA. [Talent, Larry G.] Oklahoma State Univ, Dept Nat Resource Ecol & Management, Stillwater, OK 74078 USA. [Wilbanks, Mitchell S.; Perkins, Edward J.; Gust, Kurt A.] USA, Environm Lab, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. [Nisanian, Mandana; Gogal, Robert M., Jr.] Univ Georgia, Dept Anat & Radiol, Athens, GA 30602 USA. RP McFarland, CA (reprint author), USA, Hlth Effects Res Program, Inst Publ Hlth, Edgewood Area, Bldg E-2100, Aberdeen Proving Ground, MD 21010 USA. EM craig.a.mcfarland@us.army.mil FU US Army FX We thank Pat Beall, Karen Deaver, Shane Hall, and Joseph J. Schall for their advice and technical assistance during the course of this study. The research was funded through the US Army, 6.1 Environmental Quality on Installations basic research program. The views expressed in this paper are those of the authors and do not reflect the official policy or position of the Department of Army, Department of Defense, or the U.S. Government. Mention of trade names or commercial products does not constitute endorsement or recommendation for use. NR 51 TC 5 Z9 6 U1 5 U2 59 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0963-9292 EI 1573-3017 J9 ECOTOXICOLOGY JI Ecotoxicology PD NOV PY 2012 VL 21 IS 8 BP 2372 EP 2390 DI 10.1007/s10646-012-0993-1 PG 19 WC Ecology; Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA 058WG UT WOS:000312664900027 PM 22975894 ER PT J AU Khattab, MA Eslam, M Aly, MM Shatat, M Hussen, A Moussa, YI Elsaghir, G Abdalhalim, H Aly, A Gaber, S Harrison, SA AF Khattab, Mahmoud Aboelneen Eslam, Mohammed Aly, Mayada M. Shatat, Mohammed Hussen, Azaa Moussa, Yossef I. Elsaghir, Ghada Abdalhalim, Hesham Aly, Ahmed Gaber, Salwa Harrison, Stephen A. TI Association of Serum Adipocytokines With Insulin Resistance and Liver Injury in Patients With Chronic Hepatitis C Genotype 4 SO JOURNAL OF CLINICAL GASTROENTEROLOGY LA English DT Article DE adiopcytokines; insulin resistance; chronic hepatitis C genotype 4 ID NONALCOHOLIC STEATOHEPATITIS; VIRUS-INFECTION; ADIPONECTIN; APOPTOSIS; FIBROSIS; DISEASE; STEATOSIS; RECEPTORS; ACTIVATION; MECHANISMS AB Background: Hepatitis C virus (HCV) infection, especially genotypes 1 and 4, is associated with metabolic dysfunction. We investigated the potential role of adipocytokines in HCV-induced insulin resistance (IR) and modulating the progression of liver disease in patients with HCV-4. Methods: Serum adiponectin, high molecular weight adiponectin, leptin, tumor necrosis factor-alpha, interluekin-6, homeostasis model for the assessment of insulin resistance, and M30 protein were measured in 147 HCV patients and 89 controls. Liver biopsies were evaluated for steatosis/inflammation/fibrosis, adiponectin mRNA/protein, AdipoR1/-R2 mRNA, and phosphoenolpyruvate carboxykinase gene expression, and adiponectin and CD95 immunoreactivity. Results: CD95 immunoreactivity and adiponectin immunoreactivity were detected in all biopsies examined. Hepatic adiponectin immunostaining correlated positively with the intensity of hepatic CD95/Fas immunostaining (r = 0.424; P = 0.001). Hepatocyte CD95/Fas upregulation correlated with fibrosis, inflammation, and steatosis (r = 0.52, P = 0.0001; r = 0.16, P = 0.04; r = 0.24, P = 0.0001; respectively). Significant correlations of serum adiponectin, its receptors mRNA expression, hepatic adiponectin immunostaining, and mRNA transcription for phosphoenolpyruvate carboxykinase were identified with steatosis. A positive association between adiponectin and hepatic inflammation and fibrosis was identified. This correlation remained significant even after adjusting for age, sex, and body mass index. Among body mass index, age, and sex-matched HCV-negative controls, patients with HCV-4 have higher serum leptin, adiponectin, and high molecular weight adiponectin, and these changes are independently correlated with IR. Conclusions: Our findings in patients with HCV-4 show that adiponectin correlates with IR and with the different stages of liver injury. Steatosis upregulates hepatocyte CD95/Fas and thus increases apoptosis, which facilitates inflammation and fibrosis. These findings may provide potential clues for novel therapeutic intervention. C1 [Khattab, Mahmoud Aboelneen; Eslam, Mohammed; Aly, Mayada M.; Shatat, Mohammed; Moussa, Yossef I.; Elsaghir, Ghada; Abdalhalim, Hesham] Menia Univ, Dept Internal Med, Al Minya 61111, Egypt. [Hussen, Azaa] Menia Univ, Dept Histol, Al Minya 61111, Egypt. [Gaber, Salwa] Menia Univ, Dept Pathol, Al Minya 61111, Egypt. [Harrison, Stephen A.] Brooke Army Med Ctr, Dept Med, Div Gastroenterol & Hepatol, Ft Sam Houston, TX 78234 USA. RP Khattab, MA (reprint author), Menia Univ, Div Gastroenterol & Hepatol, Dept Med, Al Minya 61111, Egypt. EM mkhattabmed@hotmail.com NR 38 TC 5 Z9 5 U1 0 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0192-0790 J9 J CLIN GASTROENTEROL JI J. Clin. Gastroenterol. PD NOV-DEC PY 2012 VL 46 IS 10 BP 871 EP 879 DI 10.1097/MCG.0b013e318256b68a PG 9 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 062WB UT WOS:000312953400019 PM 22664476 ER PT J AU Kittle, CP Verrett, AJ Wu, J Mellus, DE Hale, RG Chan, RK AF Kittle, Christopher P. Verrett, Adam J. Wu, Jesse Mellus, Davin E. Hale, Robert G. Chan, Rodney K. TI Characterization of Midface Fractures Incurred in Recent Wars SO JOURNAL OF CRANIOFACIAL SURGERY LA English DT Article DE Maxillofacial; facial fractures; early rigid fixation; blast injury ID OPERATION ENDURING FREEDOM; IRAQI-FREEDOM; CASUALTIES; INJURIES; THEATER AB Background: Facial injuries sustained by US military personnel during the wars in Iraq and Afghanistan have increased compared with past conflicts. Characterization of midface fractures (orbits, maxilla, zygoma, and nasal bones) sustained on the battlefield is needed to improve our understanding of these injuries, to optimize treatment, and to potentially direct strategic development of protective equipment in the future. Methods: The military's Joint Theater Trauma Registry was queried for midface fractures from 2001 to 2011 using International Classification of Diseases, Ninth Revision diagnosis codes. Stratification was then performed, and individual treatment records from Brooke Army Medical Center were reviewed. Analysis of the fracture pattern, treatment, and complications was performed. Results: One thousand seven hundred sixty individuals with midface fractures were identified. Those fractures sustained in battle were characterized by a predominance of open fractures, blast etiology, and associated injuries. Detailed record reviews of the patients treated at our institution revealed 45% of all midface fractures as operative. Thirty-one percent of these were treated at levels III and IV facilities outside the continental United States before arrival at our institution. Patients with midface fractures underwent multiple operations. There was a 30% rate of complication among operative fractures characterized by malalignment, implant exposure, and infection. Midface battle injuries also had a high incidence of orbital fractures and severe globe injuries. Conclusions: Midface fractures sustained in the battlefield have a high complication rate, likely as a result of the blast mechanism of injury with associated open fractures, multiple fractures, and associated injuries. These cases present unique challenges, often requiring both soft tissue and skeletal reconstruction. C1 [Mellus, Davin E.; Hale, Robert G.; Chan, Rodney K.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Kittle, Christopher P.; Wu, Jesse] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. [Verrett, Adam J.] Wilford Hall USAF Med Ctr, Lackland AFB, TX 78236 USA. RP Chan, RK (reprint author), USA, Inst Surg Res, 3650 Chambers Pass, Ft Sam Houston, TX 78234 USA. EM rodney.k.chan@us.army.mil NR 13 TC 3 Z9 4 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1049-2275 J9 J CRANIOFAC SURG JI J. Craniofac. Surg. PD NOV PY 2012 VL 23 IS 6 BP 1587 EP 1591 DI 10.1097/SCS.0b013e318256514a PG 5 WC Surgery SC Surgery GA 048DB UT WOS:000311889300055 PM 23172425 ER PT J AU Fresconi, F Harkins, T AF Fresconi, Frank Harkins, Tom TI Experimental Flight Characterization of Asymmetric and Maneuvering Projectiles from Elevated Gun Firings SO JOURNAL OF SPACECRAFT AND ROCKETS LA English DT Article; Proceedings Paper CT AIAA Atmospheric Flight Mechanics Conference CY AUG 08-11, 2011 CL Portland, OR SP AIAA ID AERODYNAMIC COEFFICIENTS; GUIDANCE; ACTUATOR AB Instrumented flight experiments were conducted to quantify flight behavior for two precision munitions programs. These projectiles were of different shapes and calibers but each featured roll-inducing tailfins and canards as their maneuver mechanisms. In this effort, aerodynamic terms for asymmetries, side moments, and control mechanisms were estimated from onboard sensor data acquired during elevated gun firings. Additionally, these experiments uncovered an in-flight reversal in coning direction of the projectile and the reasons for this behavior are described in a flight stability analysis. C1 [Fresconi, Frank] USA, Res Lab, Guided Flight Dynam Team, RDRL WML E, Aberdeen Proving Ground, MD 21005 USA. [Harkins, Tom] USA, Res Lab, RDRL WML F, Aberdeen Proving Ground, MD 21005 USA. RP Fresconi, F (reprint author), USA, Res Lab, Guided Flight Dynam Team, RDRL WML E, Aberdeen Proving Ground, MD 21005 USA. NR 32 TC 12 Z9 13 U1 0 U2 4 PU AMER INST AERONAUT ASTRONAUT PI RESTON PA 1801 ALEXANDER BELL DRIVE, STE 500, RESTON, VA 22091-4344 USA SN 0022-4650 J9 J SPACECRAFT ROCKETS JI J. Spacecr. Rockets PD NOV-DEC PY 2012 VL 49 IS 6 BP 1120 EP 1130 DI 10.2514/1.A32200 PG 11 WC Engineering, Aerospace SC Engineering GA 064NS UT WOS:000313082900016 ER PT J AU Dykes, J Montalvo, C Costello, M Sahu, J AF Dykes, John Montalvo, Carlos Costello, Mark Sahu, Jubaraj TI Use of Microspoilers for Control of Finned Projectiles SO JOURNAL OF SPACECRAFT AND ROCKETS LA English DT Article; Proceedings Paper CT AIAA Atmospheric Flight Mechanics Conference CY AUG 17-19, 2010 CL Toronto, CANADA SP AIAA AB Due to space limitations, cost restrictions, and performance challenges, the physical control mechanism on a smart projectile plays a central role in the overall system design. Many different smart projectile control mechanisms have been created including aerodynamic-based mechanisms such as movable canards, propellant-based mechanisms such as squibs, and inertia-based mechanisms such as internal moving masses. The work reported here considers small microspoilers located between rear fins of a finned projectile to create aerodynamic load changes to enable projectile control. In particular, boundary-layer shock interaction between the projectile body, fins, and microspoilers provides a multiplicative effect on controllable forces and moments induced by microspoiler activation. A parametric study varying the microspoiler configuration is conducted to examine the level of control authority possible for this control mechanism concept. Results indicate that relatively small microspoilers located between fins generate substantial control authority that is capable of eliminating impact errors caused by muzzle jump, aerodynamic uncertainty, and atmospheric winds. These conclusions are based on computational fluid dynamic predictions of the effect of microspoilers on air loads coupled to a rigid six-degree-of-freedom projectile trajectory simulation. C1 [Dykes, John] Georgia Inst Technol, Sch Mech Engn, Atlanta, GA 30332 USA. [Montalvo, Carlos; Costello, Mark] Georgia Inst Technol, Sch Aerosp Engn, Atlanta, GA 30332 USA. [Sahu, Jubaraj] USA, Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. RP Dykes, J (reprint author), Georgia Inst Technol, Sch Mech Engn, Atlanta, GA 30332 USA. OI William, John/0000-0001-7617-9148 NR 13 TC 2 Z9 2 U1 0 U2 4 PU AMER INST AERONAUT ASTRONAUT PI RESTON PA 1801 ALEXANDER BELL DRIVE, STE 500, RESTON, VA 22091-4344 USA SN 0022-4650 J9 J SPACECRAFT ROCKETS JI J. Spacecr. Rockets PD NOV-DEC PY 2012 VL 49 IS 6 BP 1131 EP 1140 DI 10.2514/1.A32274 PG 10 WC Engineering, Aerospace SC Engineering GA 064NS UT WOS:000313082900017 ER PT J AU Kaushik, D O'Fallon, K Clarkson, PM Dunne, CP Conca, KR Michniak-Kohn, B AF Kaushik, Diksha O'Fallon, Kevin Clarkson, Priscilla M. Dunne, C. Patrick Conca, Karen R. Michniak-Kohn, Bozena TI Comparison of Quercetin Pharmacokinetics Following Oral Supplementation in Humans SO JOURNAL OF FOOD SCIENCE LA English DT Article DE AUC; buccal; C-max; oral; quercetin ID RELATIVE BIOAVAILABILITY; EXERCISE PERFORMANCE; FLAVONOID QUERCETIN; HUMAN PLASMA; ABSORPTION; RAT; ACCUMULATION; METABOLITES; GLYCOSIDES; INGESTION AB The objective of the study was to investigate the absorption of quercetin aglycone in 18 healthy human subjects administered via the following oral carrier systems: suspension of quercetin (quercetin QU995 powder in Tang (R) and spring water), nutritional bars (First Strike (TM)), and chews (RealFX (TM) Q-Plus (TM)). Subjects were divided into 3 groups of 6 individuals each receiving 500 mg quercetin in one of the aforementioned formulations. Blood levels were monitored immediately pre- and for 32 h postadministration. The concentration of total quercetin in blood samples was determined by solid phase extraction followed by high-performance liquid chromatography analysis. Pharmacokinetic parameters were determined by noncompartmental modeling using Kinetica software. The C-max of quercetin was highest with RealFX (TM) Q-Plus (TM) Chews (1051.9 +/- 393.1 mu g/L) achieved within 3.3 h as compared to that for First Strike (TM) Bars (698.1 +/- 189.5 mu g/L in 2.3 h) and Tang (R) suspension (354.4 +/- 87.6 mu g/L in 4.7 h). The results showed no statistically significant difference in quercetin absorption among groups due to high variability within groups receiving quercetin from same dosage form. This study represents the first comprehensive evaluation of quercetin absorption from quercetin fortified oral food products at doses commonly used for quercetin supplementation. C1 [Kaushik, Diksha; Michniak-Kohn, Bozena] Rutgers State Univ, Ernest Mario Sch Pharm, Piscataway, NJ 08854 USA. [O'Fallon, Kevin; Clarkson, Priscilla M.] Univ Massachusetts, Muscle Biol & Imaging Lab, Dept Kinesiol, Amherst, MA 01002 USA. [Dunne, C. Patrick; Conca, Karen R.] USA, Natick Soldier Res Dev & Engn Ctr, Natick, MA 01760 USA. RP Michniak-Kohn, B (reprint author), Rutgers State Univ, Ernest Mario Sch Pharm, 145 Bevier Rd,Life Sci Bldg, Piscataway, NJ 08854 USA. EM michniak@biology.rutgers.edu FU U.S. Army [W911QY-07-C-0027] FX Funding was provided by U.S. Army Contract #W911QY-07-C-0027. The authors express gratitude to Paul Magurie and other members of Performance Optimization Research Team, Combat Feeding Directorate, US Army NSRDEC, Natick, MA for their technical support in providing special First Strike (TM) bars. NR 32 TC 12 Z9 13 U1 2 U2 30 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0022-1147 J9 J FOOD SCI JI J. Food Sci. PD NOV PY 2012 VL 77 IS 11 BP H231 EP H238 DI 10.1111/j.1750-3841.2012.02934.x PG 8 WC Food Science & Technology SC Food Science & Technology GA 057GX UT WOS:000312552200004 PM 23094941 ER PT J AU Liu, M Ma, CR Collins, G Liu, J Chen, CL Dai, C Lin, Y Shui, L Xiang, F Wang, H He, J Jiang, JC Meletis, EI Cole, MW AF Liu, Ming Ma, Chunrui Collins, Gregory Liu, Jian Chen, Chonglin Dai, Chao Lin, Yuan Shui, Li Xiang, Feng Wang, Hong He, Jie Jiang, Jiechao Meletis, Efstathios I. Cole, Melanie W. TI Interface Engineered BaTiO3/SrTiO3 Heterostructures with Optimized High-Frequency Dielectric Properties SO ACS APPLIED MATERIALS & INTERFACES LA English DT Article DE BaTiO3//SrTiO3; heretostrctures; ferroelectric thin films; epitaxial behavior; microwave dielectric properties ID BA0.5SR0.5TIO3 THIN-FILMS; MICROWAVE PHASE SHIFTERS; PULSED-LASER DEPOSITION; EPITAXIAL-GROWTH; SUPERLATTICES; COMPOSITES AB Interface engineered BaTiO3/SrTiO3 heterostructures were epitaxially grown on (001) MgO substrates by pulsed laser deposition. Microstructural characterizations by X-ray diffraction and transmission electron microscopy indicate that the as-grown heterostructures are c-axis oriented with sharp interfaces. The interface relationships between the substrate and multilayered structures were determined to be [001](SrTiO3)//[001](BaTiO3)//[001](MGO) and (100)(SrTiO3)//(100)(BaTiO3)//(100)(MGO). The high-frequency microwave (similar to 18 GHz) dielectric measurements reveal highly dependent upon the stacking period numbers and layer thicknesses. With the that the dielectric constant and dielectric loss of the nanolayered heterostructures are increase in the periodic number, or the decrease in each layer thickness, the dielectric constant dramatically increases and the dielectric loss tangent rapidly decreases. The strong interface effect were found when the combination period is larger than 16, or each STO layer is less than 6.0 nm. The optimized dielectric performance was achieved with the best value for the loss tangent (0.02) and the dielectric constant (1320), which suggests that the BTO/STO heterostructures be promising for the development of the room-temperature tunable microwave elements. C1 [Liu, Ming; Shui, Li; Xiang, Feng] Xi An Jiao Tong Univ, Int Ctr Dielect Res, Xian 710049, Peoples R China. [Liu, Ming; Shui, Li; Xiang, Feng; Wang, Hong] Xi An Jiao Tong Univ, Minist Educ, Elect Mat Res Lab, Key Lab, Xian 710049, Peoples R China. [Liu, Ming; Ma, Chunrui; Collins, Gregory; Liu, Jian; Chen, Chonglin] Univ Texas San Antonio, Dept Phys & Astron, San Antonio, TX 78249 USA. [Dai, Chao; Lin, Yuan] Univ Elect Sci & Technol China, State Key Lab Elect Thin Films & Integrated Devic, Chengdu 610054, Sichuan, Peoples R China. [He, Jie; Jiang, Jiechao; Meletis, Efstathios I.] Univ Texas Arlington, Dept Mat Sci & Engn, Arlington, TX 76019 USA. [Cole, Melanie W.] USA, Res Lab, ARL, WMRD,Rodman Mat Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Chen, CL (reprint author), Univ Texas San Antonio, Dept Phys & Astron, San Antonio, TX 78249 USA. EM cl.chen@utsa.edu RI Wang, Hong/C-1325-2008; Liu, Ming/F-5084-2010; lin, yuan/B-9955-2013 FU National Science Foundation [NSF-NIRT-0709293]; State of Texas through the ARP Program [003656-0103-2007]; Texas Center for Superconductivity at the University of Houston; Natural Science Foundation of China [11028409]; China Scholarship Council FX This research was partially supported by the National Science Foundation under NSF-NIRT-0709293, the State of Texas through the ARP Program under 003656-0103-2007 and the Texas Center for Superconductivity at the University of Houston, and the Natural Science Foundation of China under 11028409. Also, M.L. and C.M. acknowledge the support from the "China Scholarship Council" for the program of national study-abroad project for the postgraduates of high level universities at UTSA. NR 38 TC 26 Z9 26 U1 8 U2 116 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1944-8244 J9 ACS APPL MATER INTER JI ACS Appl. Mater. Interfaces PD NOV PY 2012 VL 4 IS 11 BP 5761 EP 5765 DI 10.1021/am301066u PG 5 WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary SC Science & Technology - Other Topics; Materials Science GA 043DA UT WOS:000311521900007 PM 23075425 ER PT J AU Stanzione, JF Jensen, RE Costanzo, PJ Palmese, GR AF Stanzione, Joseph F., III Jensen, Robert E. Costanzo, Philip J. Palmese, Giuseppe R. TI Synthesis and Characterization of Ionic Polymer Networks in a Room-Temperature Ionic Liquid SO ACS APPLIED MATERIALS & INTERFACES LA English DT Article DE room-temperature ionic liquids; gels; thermosets; polyacrylamides; ion transport ID FREE-RADICAL POLYMERIZATION; VINYL-ESTER; MECHANICAL-PROPERTIES; CURE KINETICS; HYDROGELS; MONOMERS; STYRENE; RESINS; METHACRYLATE; SPECTROSCOPY AB Ionic liquid gels (ILGs) for potential use in ion transport and separation applications were generated via a free radical copolymerization of 2-acrylamido-2-methyl-1-propanesulfonic acid (AMPS) and N,N'-methylene(bis)acrylamide (MBA) using 1-ethyl-3-methylimidazolium ethylsulfate (IL) as a room temperature ionic liquid solvent medium. The AMPS and MBA monomer solubility window in the IL in the temperature range of 25 to 65 degrees C was determined. In situ ATR-FTIR showed near complete conversion of monomers to a cross-linked polymer network. ILGs with glass transition temperatures (T(g)s) near -50 degrees C were generated with T-g decreasing with increasing IL content. The elastic moduli in compression (200 to 6600 kPa) decreased with increasing IL content and increasing AMPS content while the conductivities (0.35 to 2.14 mS cm(-1)) increased with increasing IL content and decreasing MBA content. The polymer-IL interaction parameter (chi) (0.48 to 0.55) was determined via a modified version of the Bray and Merrill equation. C1 [Stanzione, Joseph F., III; Palmese, Giuseppe R.] Drexel Univ, Dept Chem & Biol Engn, Philadelphia, PA 19104 USA. [Jensen, Robert E.; Costanzo, Philip J.; Palmese, Giuseppe R.] USA, Res Lab, RDRL WMM C, Aberdeen Proving Ground, MD 21005 USA. RP Palmese, GR (reprint author), Drexel Univ, Dept Chem & Biol Engn, Philadelphia, PA 19104 USA. EM palmese@coe.drexel.edu RI Costanzo, Philip/E-8879-2011 OI Costanzo, Philip/0000-0001-6220-463X FU U.S. Army Research Laboratory under the Army Materials Center of Excellence Program [W911NF-06-2-0013]; U.S. Department of Energy; US-ARL FX The authors from Drexel University acknowledge the U.S. Army Research Laboratory for financial support under the Army Materials Center of Excellence Program, Contract W911NF-06-2-0013. J.F.S. was also supported in part by an appointment to the Research Participation Program at the U.S. Army Research Laboratory administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the U.S. Department of Energy and US-ARL. P.J.C. was, by an appointment to the Research Participation Program, at the U.S. Army Research Laboratory administered by the National Research Council through an interagency agreement between the U.S. Department of Energy and US-ARL. J.F.S. also acknowledges Mr. Andres Bujanda at ARL for his assistance with mechanical testing and SEM imaging. NR 44 TC 15 Z9 16 U1 3 U2 68 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1944-8244 J9 ACS APPL MATER INTER JI ACS Appl. Mater. Interfaces PD NOV PY 2012 VL 4 IS 11 BP 6142 EP 6150 DI 10.1021/am301777h PG 9 WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary SC Science & Technology - Other Topics; Materials Science GA 043DA UT WOS:000311521900056 PM 23088450 ER PT J AU Rivera, RA Nguyen, MT Martinez-Osorio, JI McNeill, MF Ali, SK Mansi, IA AF Rivera, Raul A. Nguyen, Mai T. Martinez-Osorio, Jorge I. McNeill, Matthew F. Ali, Sayed K. Mansi, Ishak A. TI Preoperative medical consultation: maximizing its benefits SO AMERICAN JOURNAL OF SURGERY LA English DT Review DE Consultation; Medical; Medical consultation; Preoperative; Preoperative consultation; Preoperative medical consultation ID PERIOPERATIVE CARDIOVASCULAR EVALUATION; INTENSIVE INSULIN THERAPY; BETA-BLOCKER THERAPY; SEROTONIN REUPTAKE INHIBITORS; PRACTICE GUIDELINES COMMITTEE; PLACEBO-CONTROLLED TRIAL; OBSTRUCTIVE SLEEP-APNEA; CRITICALLY-ILL PATIENTS; ASSOCIATION TASK-FORCE; MAJOR VASCULAR-SURGERY AB BACKGROUND: The increasing complexity of medical and surgical care often demands comprehensive preoperative work-ups by medical consultants and detailed management recommendations to optimize the patient's medical ailments before surgery. This article aims to review the available evidence and discuss elements of the preoperative medical consultation that are of particular relevance to surgeons. METHODS: The authors performed a comprehensive review of the available medical literature and guidelines pertaining to preoperative medical management and present a narrative summary of their findings. RESULTS: Although many preoperative recommendations are based on expert opinion and consensus, a growing number of studies and clinical practice guidelines provides direction as to what is the best management of patients with medical problems before surgery. CONCLUSIONS: Collaborative efforts and adequate communication between the medical and surgical teams are necessary to ensure appropriate patient management before surgery. Although higher-risk patients may require thorough preoperative evaluations, extensive routine investigations may not always be necessary. Published by Elsevier Inc. C1 [Rivera, Raul A.; Martinez-Osorio, Jorge I.; McNeill, Matthew F.; Ali, Sayed K.; Mansi, Ishak A.] Brooke Army Med Ctr, Dept Med, Internal Med Serv, Ft Sam Houston, TX 78234 USA. [Nguyen, Mai T.] Brooke Army Med Ctr, Dept Med, Serv Nephrol, Ft Sam Houston, TX 78234 USA. RP Rivera, RA (reprint author), Brooke Army Med Ctr, Dept Med, Internal Med Serv, Ft Sam Houston, TX 78234 USA. EM raul.rivera@amedd.army.mil NR 136 TC 2 Z9 2 U1 1 U2 5 PU EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC PI BRIDGEWATER PA 685 ROUTE 202-206 STE 3, BRIDGEWATER, NJ 08807 USA SN 0002-9610 J9 AM J SURG JI Am. J. Surg. PD NOV PY 2012 VL 204 IS 5 BP 787 EP 797 DI 10.1016/j.amjsurg.2012.02.018 PG 11 WC Surgery SC Surgery GA 045YZ UT WOS:000311734000042 PM 22771448 ER PT J AU Levin, LI Chang, ET Ambinder, RF Lennette, ET Rubertone, MV Mann, RB Borowitz, M Weir, EG Abbondanzo, SL Mueller, NE AF Levin, Lynn I. Chang, Ellen T. Ambinder, Richard F. Lennette, Evelyne T. Rubertone, Mark V. Mann, Risa B. Borowitz, Michael Weir, Edward G. Abbondanzo, Susan L. Mueller, Nancy E. TI Atypical prediagnosis Epstein-Barr virus serology restricted to EBV-positive Hodgkin lymphoma SO BLOOD LA English DT Article ID REED-STERNBERG CELLS; IN-SITU HYBRIDIZATION; TERM GLOBAL DEFICIT; INFECTIOUS-MONONUCLEOSIS; ANTIBODY-RESPONSES; BURKITTS-LYMPHOMA; NUCLEAR ANTIGEN; INCREASED RISK; DISEASE; EXPRESSION AB An altered anti-Epstein-Barr virus (EBV) serologic profile preceding diagnosis is associated with an increased risk of Hodgkin lymphoma. It is unknown whether this atypical pattern predicts Hodgkin lymphoma risk further subdivided by determination of EBV in tumor cells. A nested case-control study of 128 incident Hodgkin lymphoma cases and 368 matched controls from active-duty military personnel with archived serum in the US Department of Defense Serum Repository was conducted to determine whether a panel of anti-EBV antibody titers differed in EBV+ and EBV- Hodgkin lymphoma. Among 40 EBV+ Hodgkin lymphoma cases and matched controls, statistically significant increased risks were associated with elevated anti-EBV VCA IgG antibody titers (relative risk = 3.1; 95% confidence interval [CI], 1.1-8.7), and an anti-EBNA-1/anti-EBNA-2 antibody ratio <= 1.0 versus > 1.0 (relative risk = 4.7; 95% CI, 1.6-13.8). In contrast, no significant associations were found among 88 EBV- Hodgkin lymphoma cases relative to their matched controls. In case-case analysis, EBV+ disease was significantly associated with a low anti-EBNA-1/anti-EBNA-2 antibody ratio. This distinctive serologic response to EBV latent antigens, indicative of immune dysfunction in other clinical settings, is associated with an increased risk of developing EBV+ but not EBV- Hodgkin lymphoma. (Blood. 2012; 120(18):3750-3755) C1 [Levin, Lynn I.] Walter Reed Army Inst Res, Prevent Med Program, Dept Epidemiol, Silver Spring, MD 20910 USA. [Chang, Ellen T.] Exponent Inc, Hlth Sci Practice, Menlo Pk, CA USA. [Chang, Ellen T.] Stanford Univ, Sch Med, Dept Hlth Res & Policy, Div Epidemiol, Stanford, CA 94305 USA. [Ambinder, Richard F.; Mann, Risa B.; Borowitz, Michael] Johns Hopkins Sch Med, Div Hematol Malignancies, Baltimore, MD USA. [Lennette, Evelyne T.] Virolab Inc, Emeryville, CA USA. [Rubertone, Mark V.] Armed Forces Hlth Surveillance Ctr, Silver Spring, MD USA. [Weir, Edward G.] Clin Pathol Associates, Austin, TX USA. [Abbondanzo, Susan L.] Armed Forces Inst Pathol, Dept Hematopathol, Washington, DC 20306 USA. [Mueller, Nancy E.] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA. RP Levin, LI (reprint author), Walter Reed Army Inst Res, Prevent Med Program, Dept Epidemiol, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM lynn.levin@us.army.mil FU National Cancer Institute [PO1 CA69266, P50 CA96888] FX This work was supported by the National Cancer Institute (grants PO1 CA69266 and P50 CA96888). NR 38 TC 13 Z9 13 U1 0 U2 1 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 1 PY 2012 VL 120 IS 18 BP 3750 EP 3755 DI 10.1182/blood-2011-12-390823 PG 6 WC Hematology SC Hematology GA 044MW UT WOS:000311624800018 PM 22972983 ER PT J AU Richie, TL Charoenvit, Y Wang, RB Epstein, JE Hedstrom, RC Kumar, S Luke, TC Freilich, DA Aguiar, JC Sacci, JB Sedegah, M Nosek, RA De La Vega, P Berzins, MP Majam, VF Abot, EN Ganeshan, H Richie, NO Banania, JG Baraceros, MFB Geter, TG Mere, R Bebris, L Limbach, K Hickey, BW Lanar, DE Ng, J Shi, M Hobart, PM Norman, JA Soisson, LA Hollingdale, MR Rogers, WO Doolan, DL Hoffman, SL AF Richie, Thomas L. Charoenvit, Yupin Wang, Ruobing Epstein, Judith E. Hedstrom, Richard C. Kumar, Sanjai Luke, Thomas C. Freilich, Daniel A. Aguiar, Joao C. Sacci, John B., Jr. Sedegah, Martha Nosek, Ronald A., Jr. De La Vega, Patricia Berzins, Mara P. Majam, Victoria F. Abot, Esteban N. Ganeshan, Harini Richie, Nancy O. Banania, Jo Glenna Baraceros, Maria Fe B. Geter, Tanya G. Mere, Robin Bebris, Lolita Limbach, Keith Hickey, Bradley W. Lanar, David E. Ng, Jennifer Shi, Meng Hobart, Peter M. Norman, Jon A. Soisson, Lorraine A. Hollingdale, Michael R. Rogers, William O. Doolan, Denise L. Hoffman, Stephen L. TI Clinical trial in healthy malaria-naive adults to evaluate the safety, tolerability, immunogenicity and efficacy of MuStDO5, a five-gene, sporozoite/hepatic stage Plasmodium falciparum DNA vaccine combined with escalating dose human GM-CSF DNA SO HUMAN VACCINES & IMMUNOTHERAPEUTICS LA English DT Article; Proceedings Paper CT DNA Vaccines Meeting CY JUL 12-14, 2011 CL San Diego, CA DE malaria; Plasmodium falciparum; DNA vaccine; vaccine safety; clinical trials; GM-CSF; malaria challenge; controlled human malaria infection; malaria vaccine ID COLONY-STIMULATING FACTOR; T-CELL RESPONSES; HEPATOCYTE ERYTHROCYTE PROTEIN; HUMORAL IMMUNE-RESPONSES; SERUM CREATINE-KINASE; ASEXUAL BLOOD STAGES; CIRCUMSPOROZOITE PROTEIN; VIRUS ANKARA; PROTECTIVE IMMUNITY; INTERFERON-GAMMA AB When introduced in the 1990s, immunization with DNA plasmids was considered potentially revolutionary for vaccine development, particularly for vaccines intended to induce protective CD8 T cell responses against multiple antigens. We conducted, in 1997-1998, the first clinical trial in healthy humans of a DNA vaccine, a single plasmid encoding Plasmodium falciparum circumsporozoite protein (PfCSP), as an initial step toward developing a multi-antigen malaria vaccine targeting the liver stages of the parasite. As the next step, we conducted in 2000-2001 a clinical trial of a five-plasmid mixture called MuStDO5 encoding pre-erythrocytic antigens PfCSP, PfSSP2/TRAP, PfEXP1, PfLSA1 and PfLSA3. Thirty-two, malaria-naive, adult volunteers were enrolled sequentially into four cohorts receiving a mixture of 500 mu g of each plasmid plus escalating doses (0, 20, 100 or 500 mu g) of a sixth plasmid encoding human granulocyte macrophage-colony stimulating factor (hGM-CSF). Three doses of each formulation were administered intramuscularly by needle-less jet injection at 0, 4 and 8 weeks, and each cohort had controlled human malaria infection administered by five mosquito bites 18 d later. The vaccine was safe and well-tolerated, inducing moderate antigen-specific, MHC-restricted T cell interferon-gamma responses but no antibodies. Although no volunteers were protected, T cell responses were boosted post malaria challenge. This trial demonstrated the MuStDO5 DNA and hGM-CS F plasmids to be safe and modestly immunogenic for T cell responses. It also laid the foundation for priming with DNA plasmids and boosting with recombinant viruses, an approach known for nearly 15 y to enhance the immunogenicity and protective efficacy of DNA vaccines. C1 [Richie, Thomas L.; Charoenvit, Yupin; Wang, Ruobing; Epstein, Judith E.; Hedstrom, Richard C.; Kumar, Sanjai; Luke, Thomas C.; Freilich, Daniel A.; Sacci, John B., Jr.; Sedegah, Martha; De La Vega, Patricia; Berzins, Mara P.; Majam, Victoria F.; Abot, Esteban N.; Ganeshan, Harini; Richie, Nancy O.; Banania, Jo Glenna; Baraceros, Maria Fe B.; Geter, Tanya G.; Bebris, Lolita; Limbach, Keith; Hickey, Bradley W.; Hollingdale, Michael R.; Rogers, William O.; Doolan, Denise L.; Hoffman, Stephen L.] USN, Med Res Ctr, Silver Spring, MD USA. [Wang, Ruobing; Kumar, Sanjai; Sacci, John B., Jr.; De La Vega, Patricia; Berzins, Mara P.; Majam, Victoria F.; Abot, Esteban N.; Ganeshan, Harini; Richie, Nancy O.; Banania, Jo Glenna; Baraceros, Maria Fe B.; Geter, Tanya G.; Bebris, Lolita; Limbach, Keith; Hollingdale, Michael R.] Henry M Jackson Fdn Adv Mil Med, Bethesda, MD USA. [Aguiar, Joao C.] Pan Amer Hlth Org, Washington, DC USA. [Nosek, Ronald A., Jr.] USN, Med Res Ctr, Bethesda, MD 20084 USA. [Mere, Robin; Hobart, Peter M.; Norman, Jon A.] Vical, San Diego, CA USA. [Lanar, David E.; Shi, Meng] Walter Reed Army Inst Res, Silver Spring, MD USA. [Ng, Jennifer] Def Marrow Donor Program, CW Bill Young Dept, Rockville, MD USA. [Soisson, Lorraine A.] USAID, Washington, DC USA. RP Richie, TL (reprint author), USN, Med Res Ctr, Silver Spring, MD USA. EM Thomas.Richie@med.navy.mil RI Doolan, Denise/F-1969-2015; OI Richie, Thomas/0000-0002-2946-5456 FU Naval Medical Research and Development [61102A.S13.F.A0009, 62787A.870.F.A0010, 63002A.810.F.A0011, 603792N.01889.135.A0039, 60000.000.000.A0062]; US. Agency for International Development; Office of Naval Research Advanced Technology Demonstration FX This work was supported by the Naval Medical Research and Development Command work units 61102A.S13.F.A0009, 62787A.870.F.A0010, 63002A.810.F.A0011, 603792N.01889.135.A0039 and 60000.000.000.A0062 and by the US. Agency for International Development and the Office of Naval Research Advanced Technology Demonstration. T.L.R., J.E.E., R.C.H., W.O.R., T.C.L., D.A.F., R.A.N., B.W.H. and S. L. H. were active duty military personnel at the time they contributed to this work; Y.C., M. Sedegah and D. E. L. were US Government employees. The work of these individuals was prepared as part of official government duties. Title 17 U.S.C. sic105 provides that "Copyright protection under this title is not available for any work of the United States Government." Title 17 U.S.C. sic101 defines a US Government work as a work prepared by a military service member or employee of the US Government as part of that person's official duties. The study protocol for the clinical trial presented in this manuscript was approved by the NMRC Institutional Review Board, in compliance with all applicable Federal Regulations governing protection of human subjects. All study subjects gave written informed consent. The views expressed in this article are those of the authors and do not necessarily reflect the official policy or position of the Department of the Navy, the Department of the Army, the Department of Defense or the US Government. NR 96 TC 13 Z9 14 U1 0 U2 10 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA SN 2164-5515 EI 2164-554X J9 HUM VACC IMMUNOTHER JI Human Vaccines Immunother. PD NOV PY 2012 VL 8 IS 11 SI SI BP 1564 EP 1584 DI 10.4161/hv.22129 PG 21 WC Biotechnology & Applied Microbiology; Immunology SC Biotechnology & Applied Microbiology; Immunology GA 048GD UT WOS:000311897900012 PM 23151451 ER PT J AU Grant-Klein, RJ Van Deusen, NM Badger, CV Hannaman, D Dupuy, LC Schmaljohn, CS AF Grant-Klein, Rebecca J. Van Deusen, Nicole M. Badger, Catherine V. Hannaman, Drew Dupuy, Lesley C. Schmaljohn, Connie S. TI A multiagent filovirus DNA vaccine delivered by intramuscular electroporation completely protects mice from ebola and Marburg virus challenge SO HUMAN VACCINES & IMMUNOTHERAPEUTICS LA English DT Article; Proceedings Paper CT DNA Vaccines Meeting CY JUL 12-14, 2011 CL San Diego, CA ID EQUINE ENCEPHALITIS-VIRUS; NONHUMAN-PRIMATES; HEMORRHAGIC-FEVER; MOUSE MODEL; IMMUNOGENICITY; EXPRESSION AB We glycoprotein genes of Zaire ebolavirus, Sudan ebolavirus, and Marburg marburgvirus (Musoke and Ravn). Intramuscular or intradermal delivery of the vaccines in BALB/c mice was performed using the TriGrid T electroporation device. Mice that received DNA vaccines against the individual viruses developed robust glycoprotein-specific antibody titers as determined by ELISA and survived lethal viral challenge with no display of clinical signs of infection. Survival curve analysis revealed there was a statistically significant increase in survival compared to the control groups for both the Ebola and Ravn virus challenges. These data suggest that further analysis of the immune responses generated in the mice and additional protection studies in nonhuman primates are warranted. C1 [Grant-Klein, Rebecca J.; Van Deusen, Nicole M.; Badger, Catherine V.; Dupuy, Lesley C.; Schmaljohn, Connie S.] USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. [Hannaman, Drew] Ichor Med Syst Inc, San Diego, CA USA. RP Grant-Klein, RJ (reprint author), USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. EM Rebecca.J.Klein@us.army.mil FU NIAID Grant [1U01AI082069-01] FX The authors thank Joshua Moore for performing the sample collection and blinded animal health assessments, Michelle Richards for technical help with vaccinations and Angela Silva our grants and contracts specialist. This study was supported by funding from NIAID Grant 1U01AI082069-01. NR 13 TC 13 Z9 15 U1 0 U2 19 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA SN 2164-5515 EI 2164-554X J9 HUM VACC IMMUNOTHER JI Human Vaccines Immunother. PD NOV PY 2012 VL 8 IS 11 SI SI BP 1703 EP 1706 DI 10.4161/hv.21873 PG 4 WC Biotechnology & Applied Microbiology; Immunology SC Biotechnology & Applied Microbiology; Immunology GA 048GD UT WOS:000311897900025 PM 22922764 ER PT J AU Torrieri, D Valenti, MC AF Torrieri, Don Valenti, Matthew C. TI The Outage Probability of a Finite Ad Hoc Network in Nakagami Fading SO IEEE TRANSACTIONS ON COMMUNICATIONS LA English DT Article DE Ad hoc networks; transmission capacity; Nakagami fading; spread spectrum ID CELLULAR MOBILE RADIO; WIRELESS NETWORKS; TRANSMISSION CAPACITY; INTERFERENCE; SYSTEMS; PERFORMANCE AB An ad hoc network with a finite spatial extent and number of nodes or mobiles is analyzed. The mobile locations may be drawn from any spatial distribution, and interference-avoidance protocols or protection against physical collisions among the mobiles may be modeled by placing an exclusion zone around each radio. The channel model accounts for the path loss, Nakagami fading, and shadowing of each received signal. The Nakagami m-parameter can vary among the mobiles, taking any positive value for each of the interference signals and any positive integer value for the desired signal. The analysis is governed by a new exact expression for the outage probability, defined to be the probability that the signal-to-interference-and-noise ratio (SINR) drops below a threshold, and is conditioned on the network geometry and shadowing factors, which have dynamics over much slower timescales than the fading. By averaging over many network and shadowing realizations, the average outage probability and transmission capacity are computed. Using the analysis, many aspects of the network performance are illuminated. For example, one can determine the influence of the choice of spreading factors, the effect of the receiver location within the finite network region, and the impact of both the fading parameters and the attenuation power laws. C1 [Torrieri, Don] USA, Res Lab, Adelphi, MD USA. [Valenti, Matthew C.] W Virginia Univ, Lane Dept Comp Sci & Elect Engn, Morgantown, WV 26506 USA. RP Torrieri, D (reprint author), USA, Res Lab, Adelphi, MD USA. EM dtorr@arl.army.mil; valenti@ieee.org OI Valenti, Matthew/0000-0001-6089-0509 FU National Science Foundation [CNS-0750821]; United States Army Research Laboratory [W911NF-10-0109] FX M. C. Valenti's contribution was sponsored by the National Science Foundation under Award No. CNS-0750821, and by the United States Army Research Laboratory under Contract W911NF-10-0109. NR 24 TC 40 Z9 40 U1 3 U2 7 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0090-6778 J9 IEEE T COMMUN JI IEEE Trans. Commun. PD NOV PY 2012 VL 60 IS 11 BP 3509 EP 3518 DI 10.1109/TCOMM.2012.081512.110530 PG 10 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA 047QT UT WOS:000311856300038 ER PT J AU Ng, J Ziolkowski, RW Tyo, JS Skipper, MC Abdalla, MD Martin, J AF Ng, Jackson Ziolkowski, Richard W. Tyo, J. Scott Skipper, Michael C. Abdalla, Michael D. Martin, Joshua TI An Efficient, Electrically Small, Three-Dimensional Magnetic EZ Antenna for HPM Applications SO IEEE TRANSACTIONS ON PLASMA SCIENCE LA English DT Article DE Electrically small antennas; high power microwaves; metamaterials ID EXPERIMENTAL-VERIFICATION AB Metamaterial (MTM)-inspired antennas leverage techniques that have been developed over the past decade for designing artificial materials whose electromagnetic properties can be tailored to specific applications. One of the key features of the MTM-inspired antennas is their ability to motivate electrically small antenna designs through planar and volumetric loadings of space with resonant parasitic capacitive and inductive structures. In a previous work, we developed the magnetic EZ antenna as a resonant antenna that operates below ka = 0.5. In this paper, we adapt the magnetic EZ antenna concept for use with high-power mesoband quarter-wave oscillator microwave sources that can operate with hundreds of megawatts of peak power and charge voltages in excess of 100 kV in the ultrahigh frequency (500-650 MHz) and demonstrate their performance with charge voltages up to 10 kV. The principal challenges that were overcome in this effort include field management to prevent undesired breakdown and capacitive isolation to decouple the EZ antenna from the source during the charge phase. Antenna design, modeling, and experimental verification are presented here, demonstrating an operating EZ antenna/source system at 510 MHz with antenna ka = 0.436. The results demonstrate that the EZ antenna is a viable antenna to consider when traditional high-power microwave antennas are too large to be integrated into a given platform. C1 [Ng, Jackson] Raytheon Missile Syst, RF Apertures & Mech Dept, Tucson, AZ 85756 USA. [Ziolkowski, Richard W.; Tyo, J. Scott] Univ Arizona, Coll Opt Sci, Tucson, AZ 85721 USA. [Ziolkowski, Richard W.; Tyo, J. Scott] Univ Arizona, Dept Elect & Comp Engn, Tucson, AZ 85721 USA. [Skipper, Michael C.; Abdalla, Michael D.] ASR Corp, Albuquerque, NM 87106 USA. [Martin, Joshua] USA, Space & Missile Def Command Tech Ctr, Huntsville, AL 35807 USA. RP Ng, J (reprint author), Raytheon Missile Syst, RF Apertures & Mech Dept, Tucson, AZ 85756 USA. EM jng@email.arizona.edu; ziolkowski@ece.arizona.edu; tyo@optics.arizona.edu; mcs@asrcorporation.com; mda@asrcorporation.com; josh.martin3@us.army.mil NR 18 TC 8 Z9 8 U1 0 U2 18 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0093-3813 J9 IEEE T PLASMA SCI JI IEEE Trans. Plasma Sci. PD NOV PY 2012 VL 40 IS 11 BP 3037 EP 3045 DI 10.1109/TPS.2012.2214062 PN 3 PG 9 WC Physics, Fluids & Plasmas SC Physics GA 040VU UT WOS:000311354100002 ER PT J AU Phasomkusolsil, S Tanskul, P Ratanatham, S Watcharapichat, P Phulsuksombati, D Frances, SP Lerdthusnee, K Linthicum, KJ AF Phasomkusolsil, Siriporn Tanskul, Panita Ratanatham, Supaporn Watcharapichat, Pochaman Phulsuksombati, Duangporn Frances, Stephen P. Lerdthusnee, Kriangkrai Linthicum, Kenneth J. TI Influence of Orientia tsutsugamushi Infection on the Developmental Biology of Leptotrombidium imphalum and Leptotrombidium chiangraiensis (Acari: Trombiculidae) SO JOURNAL OF MEDICAL ENTOMOLOGY LA English DT Article DE Orientia tsutsugamushi; Leptotrombidium imphalum; Leptotrombidium chiangraiensis; chigger; developmental biology ID VALLEY FEVER VIRUS; RICKETTSIA-TSUTSUGAMUSHI; SCRUB TYPHUS; VERTICAL TRANSMISSION; DELIENSE ACARI; THAILAND; SURVIVAL; PALLIDUM; ECOLOGY; ORCHARD AB Leptotrombidium chiangraiensis Tanskul & Linthicum, and Leptotrombidium imphalum Vercammen-Grandjean are important vectors of scrub typhus in rice field habitats in northern Thailand. The developmental biology of all stages of the life cycle of two generations of these species of mites infected with Orientia tsutsugamushi (Hayashi) and uninfected mites is reported. The development of the infected lines of both F-1 and F-2 L. chiangraiensis were significantly longer than their respective uninfected lines (P < 0.05). The developmental times of uninfected and infected F-1 lines of L. imphalum were not significantly different; however, F-2 infected lines took significantly longer to develop (P < 0.05). Both F-1 and F-2 generations of infected L. imphalum and L. chiangraiensis oviposited on average >150 fewer eggs than uninfected mites. C1 [Phasomkusolsil, Siriporn; Tanskul, Panita; Frances, Stephen P.; Lerdthusnee, Kriangkrai; Linthicum, Kenneth J.] Armed Forces Res Inst Med Sci, Dept Entomol, Bangkok 10400, Thailand. [Ratanatham, Supaporn] Mahidol Univ, Dept Environm Biol, Bangkok 10400, Thailand. [Watcharapichat, Pochaman; Phulsuksombati, Duangporn] Armed Forces Res Inst Med Sci, Dept Vet Med, Bangkok 10400, Thailand. RP Frances, SP (reprint author), Australian Army Malaria Inst, Enoggera, Qld 4051, Australia. EM steve.frances@defence.gov.au FU U.S. Army Medical Research and Material Command FX The authors wish to express their gratitude to Inkam Inlao, Taweesak Monkhanna, and Nittaya Khlaimanee, Department of Entomology, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand, for assistance in the field and laboratory. Funding for this project was partially provided by the U.S. Army Medical Research and Material Command. The opinions expressed are those of the authors and do not necessarily reflect those of the Australian Defense Force or the U.S. Department of Defense. NR 26 TC 3 Z9 3 U1 1 U2 11 PU ENTOMOLOGICAL SOC AMER PI LANHAM PA 10001 DEREKWOOD LANE, STE 100, LANHAM, MD 20706-4876 USA SN 0022-2585 J9 J MED ENTOMOL JI J. Med. Entomol. PD NOV PY 2012 VL 49 IS 6 BP 1270 EP 1275 DI 10.1603/ME12100 PG 6 WC Entomology; Veterinary Sciences SC Entomology; Veterinary Sciences GA 040EC UT WOS:000311303200011 PM 23270154 ER PT J AU Markunas, JK Smith, PJ Melngailis, J AF Markunas, Justin K. Smith, Peter J. Melngailis, John TI Hot embossing of thick amorphous fluoropolymer for back end processing of infrared arrays SO JOURNAL OF VACUUM SCIENCE & TECHNOLOGY B LA English DT Article ID TECHNOLOGY; POLYMERS; SILICON AB A process is presented for patterning vias into thick amorphous fluoropolymer layers for a novel In bump fabrication process, achieved using a hot embossing technique. The technique uses a patterned Si stamp that employs a two-step etching process to obtain pillars with a controlled positive sidewall angle. After embossing with the Si stamp, vias are formed in amorphous fluoropolymer layers. A postembossing blanket reactive ion etch step is then used to remove excess fluoropolymer from the bottoms of the vias, exposing a Ni film. Successful electroplating of In bumps into vias initiated at the Ni layer is demonstrated, confirming complete removal of excess fluoropolymer. (C) 2012 American Vacuum Society. [http://dx.doi.org/10.1116/1.4757287] C1 [Markunas, Justin K.; Smith, Peter J.] USA, Night Vis & Elect Sensors Directorate, Ft Belvoir, VA 22060 USA. [Melngailis, John] Univ Maryland, Dept Elect & Comp Engn, College Pk, MD 20742 USA. [Melngailis, John] Univ Maryland, Inst Res Elect & Appl Phys, College Pk, MD 20742 USA. RP Markunas, JK (reprint author), USA, Night Vis & Elect Sensors Directorate, 10221 Burbeck Rd, Ft Belvoir, VA 22060 USA. EM justin.k.markunas.civ@mail.mil NR 12 TC 0 Z9 0 U1 0 U2 7 PU A V S AMER INST PHYSICS PI MELVILLE PA STE 1 NO 1, 2 HUNTINGTON QUADRANGLE, MELVILLE, NY 11747-4502 USA SN 1071-1023 J9 J VAC SCI TECHNOL B JI J. Vac. Sci. Technol. B PD NOV PY 2012 VL 30 IS 6 AR 061601 DI 10.1116/1.4757287 PG 5 WC Engineering, Electrical & Electronic; Nanoscience & Nanotechnology; Physics, Applied SC Engineering; Science & Technology - Other Topics; Physics GA 045AV UT WOS:000311667300092 ER PT J AU Sbrockey, NM Tompa, GS Kalkur, TS Zhang, JL Alpay, SP Cole, MW AF Sbrockey, Nick M. Tompa, Gary S. Kalkur, Thottam S. Zhang, Jialan Alpay, S. Pamir Cole, Melanie W. TI Voltage induced acoustic resonance in metal organic chemical vapor deposition SrTiO3 thin film SO JOURNAL OF VACUUM SCIENCE & TECHNOLOGY B LA English DT Article ID INDUCED FERROELECTRICITY; STRONTIUM-TITANATE; GROWTH AB A solidly mounted acoustic wave resonator was fabricated using a 150 nm thick SrTiO3 film deposited by metal organic chemical vapor deposition and platinum electrodes deposited by sputtering. The substrate was (0001) sapphire with a multilayer SiO2/Ta2O5 acoustic Bragg reflector. Dielectric characterization of the SrTiO3 film showed low leakage current and the characteristic capacitance-voltage behavior of a paraelectric film. Measurement of the radio frequency transmission characteristics showed no resonance with zero bias voltage across the SrTiO3 film. At 1.0V applied DC bias, a well defined resonance peak was observed near 5.6GHz. With increasing voltage across the SrTiO3 film, the resonance increased in intensity and shifted to lower frequency. The calculated electromechanical coupling coefficient for the device was 1.3% in the range of 3-5V applied bias. The maximum observed quality factor was approximately 10. (C) 2012 American Vacuum Society. [http://dx.doi.org/10.1116/1.4757129] C1 [Sbrockey, Nick M.; Tompa, Gary S.] Struct Mat Ind Inc, Piscataway, NJ 08854 USA. [Kalkur, Thottam S.] Univ Colorado, Dept Elect & Comp Engn, Colorado Springs, CO 80933 USA. [Zhang, Jialan; Alpay, S. Pamir] Univ Connecticut, Mat Sci & Engn Program, Storrs, CT 06269 USA. [Zhang, Jialan; Alpay, S. Pamir] Univ Connecticut, Inst Mat Sci, Storrs, CT 06269 USA. [Cole, Melanie W.] USA, Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. RP Sbrockey, NM (reprint author), Struct Mat Ind Inc, Piscataway, NJ 08854 USA. EM sbrockey@structuredmaterials.com RI Alpay, Pamir/E-2666-2013 FU Army Research Office [W911NF-11-C-0219] FX This work was funded by the Army Research Office under Contract Number W911NF-11-C-0219. S. P. A. and J.Z. would like to thank Dr. Lichun Zhang and Dr. Roger Ristau (UConn-IMS) for their help with sample preparations for the SEM and AFM measurements. NR 25 TC 10 Z9 10 U1 0 U2 11 PU A V S AMER INST PHYSICS PI MELVILLE PA STE 1 NO 1, 2 HUNTINGTON QUADRANGLE, MELVILLE, NY 11747-4502 USA SN 1071-1023 J9 J VAC SCI TECHNOL B JI J. Vac. Sci. Technol. B PD NOV PY 2012 VL 30 IS 6 AR 061202 DI 10.1116/1.4757129 PG 5 WC Engineering, Electrical & Electronic; Nanoscience & Nanotechnology; Physics, Applied SC Engineering; Science & Technology - Other Topics; Physics GA 045AV UT WOS:000311667300086 ER PT J AU Dion, GR Eller, RL Thomas, RF AF Dion, Gregory R. Eller, Robert L. Thomas, Roy F. TI Diagnosing Aerodynamic Supraglottic Collapse With Rest and Exercise Flexible Laryngoscopy SO JOURNAL OF VOICE LA English DT Article DE Supraglottic collapse; Inspiratory stridor; Abnormal arytenoid motion; Arytenoids; Laryngomalacia; Adult laryngomalacia; Exercise induced laryngomalacia ID VOCAL FOLD MOVEMENT; INDUCED LARYNGOMALACIA; ABNORMAL MOVEMENT; DYSFUNCTION; OBSTRUCTION; MANAGEMENT; PATIENT; MOTION; ASTHMA; COUGH AB Objective. Laryngomalacia is best known as a self-resolving infantile disorder characterized by inspiratory stridor with occlusion of the larynx by collapse of arytenoid tissues due to Bernoulli forces. Adult laryngomalacia has been sporadically described in the literature. We identified a series of patients with aerodynamic supraglottic collapse mimicking laryngomalacia in our Otolaryngology clinic. Study Design. Case series. Methods/Patients. A series of five patients from our Otolaryngology clinic with aerodynamic supraglottic collapse presented with complaints ranging from noisy breathing to dyspnea with exertion. Diagnosis was made using rest and exercise flexible laryngoscopy. Results. Symptoms resolved in all patients who underwent traditional or modified supraglottoplasty. Conclusions. These patients, all with abnormal corniculate/cuneiform motion occluding the airway during forceful inspiration, reinforce the diagnostic role of rest and exercise flexible laryngoscopy in patients with dyspnea and stridor. These results may suggest that aerodynamic supraglottic collapse is an underdiagnosed clinical entity. C1 [Dion, Gregory R.; Thomas, Roy F.] Brooke Army Med Ctr, Dept Otolaryngol Head & Neck Surg, San Antonio, TX USA. [Eller, Robert L.] Wilford Hall USAF Med Ctr, Dept Otolaryngol Head & Neck Surg, San Antonio, TX USA. RP Dion, GR (reprint author), San Antonio Mil Med Ctr SAMMC Otolaryngol, ATTN MCHE SDT Oto 3551 Roger Brooke Dr Ft Sam, Houston, TX 78234 USA. EM greg.r.dion@us.army.mil NR 26 TC 9 Z9 9 U1 0 U2 3 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0892-1997 J9 J VOICE JI J. Voice PD NOV PY 2012 VL 26 IS 6 BP 779 EP 784 DI 10.1016/j.jvoice.2012.01.004 PG 6 WC Otorhinolaryngology SC Otorhinolaryngology GA 041VC UT WOS:000311428300015 PM 22721783 ER PT J AU Crenshaw, ME Bander, TB AF Crenshaw, Michael E. Bander, Thomas B. TI Electromagnetic energy, momentum, and angular momentum in an inhomogeneous linear dielectric SO OPTICS COMMUNICATIONS LA English DT Article DE Electromagnetic momentum; Abraham-Minkowski controversy; Helmholtz force; Energy-momentum tensor ID MEDIA AB In a previous work, Optics Communications 284 (2011) 2460-2465, we considered a dielectric medium with an anti-reflection coating and a spatially uniform index of refraction illuminated at normal incidence by a quasimonochromatic field. Using the continuity equations for the electromagnetic energy density and the Gordon momentum density, we constructed a traceless, symmetric energy-momentum tensor for the closed system. In this work, we relax the condition of a uniform index of refraction and consider a dielectric medium with a spatially varying index of refraction that is independent of time, which essentially represents a mechanically rigid dielectric medium due to external constraints. Using continuity equations for energy density and for Gordon momentum density, we construct a symmetric energy-momentum matrix, whose four-divergence is equal to a generalized Helmholtz force density four-vector. Assuming that the energy-momentum matrix has tensor transformation properties under a symmetry group of space-time coordinate transformations, we derive the global conservation laws for the total energy, momentum, and angular momentum. Published by Elsevier B.V. C1 [Crenshaw, Michael E.; Bander, Thomas B.] USA, Aviat & Missile Res Dev & Engn Ctr, Redstone Arsenal, AL 35898 USA. RP Crenshaw, ME (reprint author), USA, Aviat & Missile Res Dev & Engn Ctr, Redstone Arsenal, AL 35898 USA. EM mcrenshaw@knology.net; thomas.bander@us.army.mil NR 15 TC 3 Z9 3 U1 1 U2 9 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0030-4018 J9 OPT COMMUN JI Opt. Commun. PD NOV 1 PY 2012 VL 285 IS 24 BP 5180 EP 5183 DI 10.1016/j.optcom.2012.08.021 PG 4 WC Optics SC Optics GA 038TH UT WOS:000311196500077 ER PT J AU Brandt, HE AF Brandt, Howard E. TI Microcausality in quantum field theory SO PHYSICA SCRIPTA LA English DT Article ID SPACETIME TANGENT BUNDLE; VACUUM AB Microcausality in quantum field theory in Minkowski spacetime is addressed in terms of a possible physical upper bound on proper acceleration relative to the vacuum, and the light cone and associated boundary of the causal domain are shown to be warped near the Planck scale. C1 USA, Res Lab, Adelphi, MD USA. RP Brandt, HE (reprint author), USA, Res Lab, Adelphi, MD USA. EM howard.e.brandt.civ@mail.mil NR 11 TC 0 Z9 0 U1 0 U2 1 PU IOP PUBLISHING LTD PI BRISTOL PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND SN 0031-8949 J9 PHYS SCRIPTA JI Phys. Scr. PD NOV PY 2012 VL T151 AR 014011 DI 10.1088/0031-8949/2012/T151/014011 PG 5 WC Physics, Multidisciplinary SC Physics GA 049DH UT WOS:000311961700012 ER PT J AU Zhou, Q Lambert, JH Karvetski, CW Keisler, JM Linkov, I AF Zhou, Qian Lambert, James H. Karvetski, Christopher W. Keisler, Jeffrey M. Linkov, Igor TI Flood Protection Diversification to Reduce Probabilities of Extreme Losses SO RISK ANALYSIS LA English DT Article DE Catastrophic events; climate change; dike rings; economic analysis; flood risk; return period ID SEA-LEVEL RISE; CLIMATE-CHANGE; DECISION-ANALYSIS; MANAGEMENT; UNCERTAINTY; SCENARIOS; SELECTION; VARIANCE; SYSTEMS; FUTURE AB Recent catastrophic losses because of floods require developing resilient approaches to flood risk protection. This article assesses how diversification of a system of coastal protections might decrease the probabilities of extreme flood losses. The study compares the performance of portfolios each consisting of four types of flood protection assets in a large region of dike rings. A parametric analysis suggests conditions in which diversifications of the types of included flood protection assets decrease extreme flood losses. Increased return periods of extreme losses are associated with portfolios where the asset types have low correlations of economic risk. The effort highlights the importance of understanding correlations across asset types in planning for large-scale flood protection. It allows explicit integration of climate change scenarios in developing flood mitigation strategy. C1 [Zhou, Qian; Lambert, James H.] Univ Virginia, Dept Syst & Informat Engn, Charlottesville, VA 22904 USA. [Karvetski, Christopher W.] George Mason Univ, Dept Appl Informat Technol, Fairfax, VA 22030 USA. [Keisler, Jeffrey M.] Univ Massachusetts, Coll Management, Boston, MA 02125 USA. [Linkov, Igor] USA, Corps Engineers, Engineer Res & Dev Ctr, Boston, MA USA. RP Lambert, JH (reprint author), Univ Virginia, Dept Syst & Informat Engn, POB 400736, Charlottesville, VA 22904 USA. EM lambert@virginia.edu FU USACE Civil Works Basic Research Program; U.S. Army Engineer Research and Development Center; Department of Army Installation Technology Transfer Program FX This effort was sponsored in part by the USACE Civil Works Basic Research Program, by the U.S. Army Engineer Research and Development Center, and by the Department of Army Installation Technology Transfer Program. Permission was granted by the USACE Chief of Engineers to publish this material. The views and opinions expressed in this article are those of the individual authors and not those of the U.S. Army, or other sponsor organizations. NR 46 TC 6 Z9 8 U1 2 U2 28 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0272-4332 J9 RISK ANAL JI Risk Anal. PD NOV PY 2012 VL 32 IS 11 BP 1873 EP 1887 DI 10.1111/j.1539-6924.2012.01870.x PG 15 WC Public, Environmental & Occupational Health; Mathematics, Interdisciplinary Applications; Social Sciences, Mathematical Methods SC Public, Environmental & Occupational Health; Mathematics; Mathematical Methods In Social Sciences GA 040DJ UT WOS:000311300500006 PM 22817779 ER PT J AU Mitrophanov, AY Rosendaal, FR Reifman, J AF Mitrophanov, Alexander Y. Rosendaal, Frits R. Reifman, Jaques TI Computational analysis of intersubject variability and thrombin generation in dilutional coagulopathy SO TRANSFUSION LA English DT Article ID PROTHROMBIN COMPLEX CONCENTRATE; RECOMBINANT FACTOR VIIA; VITRO THROMBELASTOGRAPHY MEASUREMENTS; NATURAL COLLOID RESUSCITATION; FRESH-FROZEN PLASMA; VIVO BLEEDING-TIME; TISSUE FACTOR; BLOOD-COAGULATION; IN-VITRO; HYPOTHERMIC COAGULOPATHY AB BACKGROUND: Blood dilution is a frequent complication of massive transfusion during trauma and surgery. This article investigates the quantitative effects of blood plasma dilution on thrombin generation in the context of intersubject variability. STUDY DESIGN AND METHODS: A thoroughly validated computational model was used to simulate thrombin generation curves for 472 healthy subjects in the Leiden Thrombophilia Study. Individual thrombin curves were calculated for undiluted blood and for different dilution scenarios. For every such curve, five standard quantitative parameters of thrombin generation were calculated and analyzed. RESULTS: Thrombin generation parameters in diluted blood plasma displayed significant intersubject variability (with a coefficient of variation up to approx. 28%). Nevertheless, dilutional effects in the majority (or all) of the subjects in the study group were characterized by persistent patterns. In particular, the largest dilution-induced change typically occurred in the maximum slope (MS) of the thrombin curve, followed by a change in thrombin peak height (PH), whereas the smallest change often occurred in the area under the curve. The identified patterns demonstrated considerable robustness to variations in dilution scenario and tissue factor concentration. CONCLUSION: Dilutional effects on thrombin generation in a human population can be predicted from trends identified for the average subject and then refined by performing an analysis of actual subjects in the study group. The MS and PH are dilution indicators that are both sensitive and reliable across a large subject group and could potentially be used as disease markers in the diagnosis of coagulopathic conditions. C1 [Mitrophanov, Alexander Y.] USA, DoD Biotechnol High Performance Comp Software App, Telemed & Adv Technol Res Ctr, Med Res & Mat Command,ATTN MCMR TT, Ft Detrick, MD 21702 USA. Leiden Univ, Med Ctr, Dept Clin Epidemiol, Leiden, Netherlands. Leiden Univ, Med Ctr, Hemostasis & Thrombosis Res Ctr, Leiden, Netherlands. RP Mitrophanov, AY (reprint author), USA, DoD Biotechnol High Performance Comp Software App, Telemed & Adv Technol Res Ctr, Med Res & Mat Command,ATTN MCMR TT, 504 Scott St, Ft Detrick, MD 21702 USA. EM alex@bioanalysis.org; jaques.reifman@us.army.mil FU US Army Medical Research and Materiel Command, Ft. Detrick, MD, as part of the US Army's Network Science Initiative FX AYM and JR were supported by the Military Operational Medicine Research Program of the US Army Medical Research and Materiel Command, Ft. Detrick, MD, as part of the US Army's Network Science Initiative. NR 62 TC 11 Z9 11 U1 0 U2 7 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0041-1132 J9 TRANSFUSION JI Transfusion PD NOV PY 2012 VL 52 IS 11 BP 2475 EP 2486 DI 10.1111/j.1537-2995.2012.03610.x PG 12 WC Hematology SC Hematology GA 035VB UT WOS:000310977500028 PM 22429019 ER PT J AU Morrison, MP O'Rourke, A Dion, GR Eller, RL Weinberger, P Postma, GN AF Morrison, Michele P. O'Rourke, Ashli Dion, Gregory R. Eller, Robert L. Weinberger, Paul Postma, Gregory N. TI Hemodynamic Changes During Otolaryngological Office-Based Flexible Endoscopic Procedures SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article; Proceedings Paper CT Meeting of the American-Broncho-Esophagological-Association CY APR 18-19, 2012 CL San Diego, CA SP Amer Broncho Esophagol Assoc DE endoscopy; hypertension; larynx; laser; office-based surgery; tachycardia ID LARYNGEAL PROCEDURES; LASER-SURGERY; MORTALITY AB Objectives: A preponderance of literature supports the safety of office-based flexible endoscopic procedures of the upper aerodigestive tract; however, until recently there were no data regarding hemodynamic stability during these procedures. A recent study showed intraprocedure changes in patients' hemodynamic parameters, raising the concern that perhaps patients should be monitored during these procedures. The aim of our study was to determine whether physiologically significant alterations in vital signs occur during office-based flexible endoscopic procedures. Methods: We performed a retrospective review of 100 consecutive patients who underwent office-based flexible endoscopic procedures of the upper aerodigestive tract from July 2010 to October 2011. Baseline values and the maximal changes in systolic blood pressure, diastolic blood pressure, heart rate, and oxygen saturation were recorded and compared. Results: One hundred consecutive patients were included in the study. Twenty-one patients (21%) had severe hypertension and 40 patients (40%) had tachycardia during the procedure. The mean change overall in systolic blood pressure was 26.2 mm Hg (p < 0.001), the mean change in diastolic blood pressure was 13.9 mm Hg (p < 0.001), the mean change in heart rate was 16.6 beats per minute (p < 0.001), and the mean change in oxygen saturation was 1.6% (p < 0.001). These changes were significant. On further breakdown into groups, patients over 50 years of age and patients who were undergoing esophageal or laser procedures had significant elevations in heart rate (p = 0.01 and p = 0.04, respectively). An elevation in diastolic blood pressure was also significant in patients who were undergoing esophageal or laser procedures (p = 0.04 for both). Conclusions: These data concur with those of the previous report that found potentially significant hemodynamic changes during office-based procedures. Although preliminary, our findings suggest that it may be wise to monitor vital signs in patients over 50 years of age and patients who are undergoing an esophageal or laser procedure who are at risk for complications that could arise from tachycardia and hypertension. C1 [Morrison, Michele P.; O'Rourke, Ashli; Weinberger, Paul; Postma, Gregory N.] Georgia Hlth Sci Univ, Dept Otolaryngol Head & Neck Surg, Voice Airway & Swallowing Ctr, Augusta, GA USA. [Dion, Gregory R.; Eller, Robert L.] Brooke Army Med Ctr, Dept Otolaryngol Head & Neck Surg, San Antonio, TX USA. RP Morrison, MP (reprint author), USN, Med Ctr Portsmouth, 620 John Paul Jones Circle, Portsmouth, VA 23708 USA. RI Weinberger, Paul/B-7007-2008 OI Weinberger, Paul/0000-0002-5885-2631 NR 15 TC 3 Z9 3 U1 0 U2 0 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD NOV PY 2012 VL 121 IS 11 BP 714 EP 718 PG 5 WC Otorhinolaryngology SC Otorhinolaryngology GA 042JR UT WOS:000311468000003 PM 23193903 ER PT J AU Crothers, BA Booth, CN Darragh, TM Means, MM Ma, L Souers, RJ Thomas, N Moriarty, AT AF Crothers, Barbara A. Booth, Christine N. Darragh, Teresa M. Means, Marilee M. Ma, Ly Souers, Rhona J. Thomas, Nicole Moriarty, Ann T. TI Atrophic Vaginitis Concordance and Interpretation of Slides in the College of American Pathologists Cervicovaginal Interlaboratory Comparison Program in Gynecologic Cytopathology SO ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE LA English DT Article ID POSTMENOPAUSAL VAGINAL ATROPHY; ATYPICAL SQUAMOUS-CELLS; CYTOLOGY; SMEARS; WOMEN; DIAGNOSIS; ESTRADIOL; TRIAL AB Context.-Atrophic vaginitis is a commonly reported subset of Papanicolaou test results that are negative for intraepithelial lesion or malignancy, but interpretive criteria overlap with atrophic changes and other entities, hindering concordance among observers. Objectives.-To report on the participant concordance from 2000 to 2009 in the College of American Pathologists Interlaboratory Comparison Program in Gynecologic Cytopathology, with a reference interpretation of atrophic vaginitis, and to investigate cytologic features of good and poorly performing slides to identify criteria useful in the interpretation of atrophic vaginitis. Design.-We summarized 18 302 responses from the program for slides with a reference interpretation of atrophic vaginitis. We randomly selected 18 Papanicolaou test results (3 conventional, 4 SurePath, and 11 ThinPrep) from good and poor performers for prospective, blinded criteria scoring for the following features: abundance of neutrophils, more than 100 degenerating parabasal cells, more than 25% necrotic background, more than 100 pseudoparakeratotic cells, and the presence of stripped or streaked nuclei, histiocytes, and superficial or intermediate squamous cells. Results.-Most Papanicolaou test results (>90%) with a specific reference interpretation of atrophic vaginitis were categorized as negative. Cytotechnologists are more likely than pathologists are to label it negative for intraepithelial lesion or malignancy (NILM) and are equally likely to mistake it for a high-grade lesion. Degenerating parabasal cells, pseudoparakeratosis, and necrotic background are associated with atrophic vaginitis (P = .001) on Papanicolaou. Abundant neutrophils (>100 per x400 field) are also significantly correlated (P = .01). Conclusions.-Exact concordance to atrophic vaginitis is less than 90%. Most of the discrepancies are negative results for intraepithelial lesion or malignancy. Advanced atrophic features are as significant as neutrophils are to the interpretation of atrophic vaginitis. (Arch Pathol Lab Med. 2012;136:1332-1338; doi:10.5858/arpa.2011-0441-CP) C1 [Crothers, Barbara A.] Walter Reed Army Med Ctr, Dept Pathol, Washington, DC 20307 USA. [Crothers, Barbara A.] Walter Reed Army Med Ctr, Area Lab Serv, Washington, DC 20307 USA. [Booth, Christine N.] Cleveland Clin Fdn, Dept Anat Pathol, Cleveland, OH 44195 USA. [Darragh, Teresa M.] Univ Calif San Francisco, Mt Zion Med Ctr, Pathol Cytol Lab, San Francisco, CA USA. [Means, Marilee M.] Univ Kansas, Dept Cytopathol, Med Ctr, Kansas City, MO USA. [Ma, Ly] Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Dept Pathol, New Brunswick, NJ 08903 USA. [Souers, Rhona J.] Coll Amer Pathologists, Dept Biostat, Northfield, IL USA. [Thomas, Nicole] Coll Amer Pathologists, Dept Surveys, Northfield, IL USA. [Moriarty, Ann T.] AmeriPath Indiana, Dept Pathol, Indianapolis, IN USA. RP Crothers, BA (reprint author), Walter Reed Natl Mil Med Ctr, Dept Pathol, 8901 Wisconsin Ave, Bethesda, MD 20889 USA. EM Barbara.crothers@med.navy.mil NR 18 TC 4 Z9 4 U1 0 U2 1 PU COLL AMER PATHOLOGISTS PI NORTHFIELD PA C/O KIMBERLY GACKI, 325 WAUKEGAN RD, NORTHFIELD, IL 60093-2750 USA SN 0003-9985 J9 ARCH PATHOL LAB MED JI Arch. Pathol. Lab. Med. PD NOV PY 2012 VL 136 IS 11 BP 1332 EP 1338 DI 10.5858/arpa.2011-0441-CP PG 7 WC Medical Laboratory Technology; Medicine, Research & Experimental; Pathology SC Medical Laboratory Technology; Research & Experimental Medicine; Pathology GA 032NJ UT WOS:000310725700004 PM 23106578 ER PT J AU Seigel, JK Stadler, ME Lombrano, JL Almony, JS Couch, ME Belhorn, TH AF Seigel, Jonathan K. Stadler, Michael E. Lombrano, Jennifer L. Almony, Jeffrey S. Couch, Marion E. Belhorn, Thomas H. TI Chromobacterium violaceum necrotizing fasciitis: A case report and review of the literature SO ENT-EAR NOSE & THROAT JOURNAL LA English DT Review ID CHRONIC GRANULOMATOUS-DISEASE; FATAL SEPTICEMIA; INFECTION; CHILDREN AB Necrotizing fasciitis is a severe, rapidly progressive infection of the subcutaneous tissue that causes significant destruction. It is rarely encountered in the pediatric population. We describe the case of a 14-year-old boy who was diagnosed with Chromobacterium violaceum necrotizing fasciitis and subsequently found to have autosomal recessive chronic granulomatous disease. C1 [Seigel, Jonathan K.] Duke Univ, Sch Med, Dept Pediat, Durham, NC USA. [Stadler, Michael E.] Med Coll Wisconsin, Dept Otolaryngol & Commun Sci, Milwaukee, WI 53226 USA. [Almony, Jeffrey S.] Womack Army Med Ctr, Dent Clin, Ft Bragg, NC USA. [Couch, Marion E.] Univ Vermont, Dept Surg, Div Otolaryngol Head & Neck Surg, Burlington, VT 05405 USA. [Belhorn, Thomas H.] Univ N Carolina, Sch Med, Dept Pediat, Chapel Hill, NC USA. RP Belhorn, TH (reprint author), UNC Pediatrics Infect Dis, 2242 Genome Sci,CB 7231,250 Bell tower Dr, Chapel Hill, NC 27599 USA. EM tom_belhorn@med.unc.edu NR 9 TC 4 Z9 4 U1 0 U2 1 PU VENDOME GROUP LLC PI NEW YORK PA 149 FIFTH AVE, 10TH FLOOR, NEW YORK, NY 10010 USA SN 0145-5613 J9 ENT-EAR NOSE THROAT JI ENT-Ear Nose Throat J. PD NOV PY 2012 VL 91 IS 11 BP 479 EP 483 PG 5 WC Otorhinolaryngology SC Otorhinolaryngology GA 043FZ UT WOS:000311529600006 PM 23288793 ER PT J AU Paulus, M Dasgupta, A Habtour, E AF Paulus, M. Dasgupta, A. Habtour, Ed TI Life estimation model of a cantilevered beam subjected to complex random vibration SO FATIGUE & FRACTURE OF ENGINEERING MATERIALS & STRUCTURES LA English DT Article DE damage accumulation; fatigue; fracture; frequency shift; power spectral density; random vibration AB An analytic methodology was developed to predict the fatigue life of a structure experiencing stationary, Gaussian random vibration excitation. This method allows the estimation of fatigue life using a frequency domain method, where only the input power spectral density and damping factor are required. The methodology uses linear elastic fracture mechanics for fatigue crack propagation and accounts for the frequency shifting that occurs due to fatigue crack evolution. Good results have been obtained comparing the analytic model to both finite element analysis (FEA) and experimental results, for mild-steel cantilever beams. C1 [Paulus, M.] USN, Undersea Warfare Ctr Div Keyport, Keyport, WA 98345 USA. [Dasgupta, A.] Univ Maryland, CALCE, College Pk, MD 20742 USA. [Habtour, Ed] USA, Res Lab, RDRL VTV, Aberdeen Proving Ground, MD 21005 USA. RP Paulus, M (reprint author), USN, Undersea Warfare Ctr Div Keyport, 610 Dowell St, Keyport, WA 98345 USA. EM mark.paulus@navy.mil OI Habtour, Ed/0000-0002-9083-9285 FU Office of Naval Research, N-Star program through the In-house Laboratory Independent Research (ILIR); Office of Naval Research, N-Star program, through Naval Innovative Science and Engineering (NISE) FX This work was supported by the Office of Naval Research, N-Star program, through the In-house Laboratory Independent Research (ILIR) and Naval Innovative Science and Engineering (NISE) programs. Distribution Statement A: Approved for Public Release; Distribution is unlimited. NR 20 TC 8 Z9 8 U1 0 U2 17 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 8756-758X J9 FATIGUE FRACT ENG M JI Fatigue Fract. Eng. Mater. Struct. PD NOV PY 2012 VL 35 IS 11 BP 1058 EP 1070 DI 10.1111/j.1460-2695.2012.01693.x PG 13 WC Engineering, Mechanical; Materials Science, Multidisciplinary SC Engineering; Materials Science GA 041FH UT WOS:000311382800007 ER PT J AU Fletes, F Kwak, E AF Fletes, Francisco Kwak, Elizabeth TI FDA approved psychotropic medications list for psychiatric illnesses commonly seen in current US population and comparison with Europe SO INTERNATIONAL JOURNAL OF PSYCHIATRY IN CLINICAL PRACTICE LA English DT Meeting Abstract C1 [Fletes, Francisco; Kwak, Elizabeth] Tripler Army Med Ctr, Dept Psychiat, Honolulu, HI 96859 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU INFORMA HEALTHCARE PI LONDON PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND SN 1365-1501 J9 INT J PSYCHIAT CLIN JI Int. J. Psychiat. Clin. PD NOV PY 2012 VL 16 SU 1 BP 27 EP 27 PG 1 WC Psychiatry SC Psychiatry GA 033PD UT WOS:000310809300057 ER PT J AU Farr, JN Charkoudian, N Barnes, JN Monroe, DG McCready, LK Atkinson, EJ Amin, S Melton, LJ Joyner, MJ Khosla, S AF Farr, Joshua N. Charkoudian, Nisha Barnes, Jill N. Monroe, David G. McCready, Louise K. Atkinson, Elizabeth J. Amin, Shreyasee Melton, L. Joseph, III Joyner, Michael J. Khosla, Sundeep TI Relationship of Sympathetic Activity to Bone Microstructure, Turnover, and Plasma Osteopontin Levels in Women SO JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM LA English DT Article ID BETA-ADRENERGIC-RECEPTORS; QUANTITATIVE COMPUTED-TOMOGRAPHY; ARTERIAL-PRESSURE REGULATION; OSTEOBLAST-LIKE CELLS; POSTMENOPAUSAL WOMEN; DISTAL RADIUS; HR-PQCT; BAROREFLEX SENSITIVITY; MINERAL DENSITY; NERVOUS-SYSTEM AB Context: Studies in rodents have demonstrated that sympathetic activity reduces bone formation and bone mass; these effects are mediated by the noncollagenous matrix protein, osteopontin. Objective: The objective of the study was to relate sympathetic activity (measured using micro-neurography at the peroneal nerve) to bone microstructure (assessed by high resolution peripheral quantitative computed tomography), bone turnover, and plasma osteopontin levels. Design, Setting, and Patients: Twenty-three women aged 20-72 yr (10 premenopausal and 13 postmenopausal) were studied in the Clinical Research Unit. Results: Sympathetic activity (bursts per 100 heart beats) was 2.4-fold higher in postmenopausal as compared with premenopausal women (P < 0.001). In the two groups combined and after age adjustment, sympathetic activity was inversely correlated with trabecular bone volume fraction (r = -0.55, P < 0.01) and thickness (r = -0.59, P < 0.01) and positively correlated with trabecular separation (r = 0.45, P < 0.05). Sympathetic activity was negatively correlated with serum amino-terminal propeptide of type I collagen in postmenopausal women (r = -0.65, P = 0.015), with a similar trend in premenopausal women (r = -0.58, P = 0.082). Sympathetic activity was also negatively correlated with plasma osteopontin levels (r = -0.43, P = 0.045), driven mainly by the correlation in postmenopausal women (r = -0.76, P = 0.002). Conclusion: These findings represent the first demonstration in humans of a relationship between sympathetic activity and bone microstructure and circulating levels of amino-terminal propeptide of type I collagen and osteopontin. Given the critical role of osteopontin in mediating the effects of beta-adrenergic signaling on bone, the inverse association between sympathetic activity and plasma osteopontin levels may reflect a negative feedback loop to limit the deleterious effects of sympathetic activity on bone metabolism. Based on the higher sympathetic activity observed in postmenopausal women, additional human studies are needed to define the role of increased sympathetic activity in mediating postmenopausal bone loss. (J Clin Endocrinol Metab 97:4219-4227, 2012) C1 [Farr, Joshua N.; Barnes, Jill N.; Monroe, David G.; McCready, Louise K.; Atkinson, Elizabeth J.; Amin, Shreyasee; Melton, L. Joseph, III; Joyner, Michael J.; Khosla, Sundeep] Mayo Clin, Coll Med, Rochester, MN 55905 USA. [Charkoudian, Nisha] USA, Environm Med Res Inst, Natick, MA 01760 USA. RP Khosla, S (reprint author), Mayo Clin, Coll Med, 200 1st St SW, Rochester, MN 55905 USA. EM khosla.sundeep@mayo.edu OI Khosla, Sundeep/0000-0002-2936-4372 FU National Institutes of Health [AG004875, AR027065, HL083947, T32 DK007352, UL1 RR024150] FX This work was supported by National Institutes of Health Grants AG004875, AR027065, HL083947, T32 DK007352, and UL1 RR024150 (to the Mayo Center for Translational Science Activities). NR 37 TC 20 Z9 20 U1 0 U2 3 PU ENDOCRINE SOC PI WASHINGTON PA 2055 L ST NW, SUITE 600, WASHINGTON, DC 20036 USA SN 0021-972X EI 1945-7197 J9 J CLIN ENDOCR METAB JI J. Clin. Endocrinol. Metab. PD NOV PY 2012 VL 97 IS 11 BP 4219 EP 4227 DI 10.1210/jc.2012-2381 PG 9 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA 032IT UT WOS:000310710500074 PM 22948767 ER PT J AU Huang, XZ Cash, DM Chahine, MA Nikolich, MP Craft, DW AF Huang, Xiao-Zhe Cash, Dana M. Chahine, Mohamad A. Nikolich, Mikeljon P. Craft, David W. TI Development and validation of a multiplex TaqMan real-time PCR for rapid detection of genes encoding four types of class D carbapenemase in Acinetobacter baumannii SO JOURNAL OF MEDICAL MICROBIOLOGY LA English DT Article ID RESISTANCE; INFECTIONS AB A multiplex TagMan real-time PCR to detect carbapenem-hydrolysing class D beta-lactamases (bla(OXA-23)-like, bla(OXA-24/40)-like, bla(OXA-51)-like and bla(OXA-58)-like genes) was developed and evaluated for early detection of imipenem (IMP) resistance in clinically significant Acinetobacter baumannii isolates. Well-characterized strains of A. baumannii were used as positive controls and non-Acinetobacter strains were used to assess specificity. Analytical sensitivity was quantified by comparison with the number of bacterial c.f.u. Forty of 46 (87 %) clinically significant and IMP-resistant A. baumannii isolates were positive for the bla(OXA-23)-like gene, and one isolate (2 %) was positive for the bla(OXA-58)-like gene. The bla(OXA-24/40)-like gene was not detected in any of the 46 IMP-resistant strains and the bla(OXA-51)-like gene was identified in both IMP-resistant and non-resistant A. baumannii. All 11 non-Acinetobacter bacteria produced a negative result for each of the four bla(OXA) genes. This assay was able to detect as few as 10 c.f.u. per assay. This real-time PCR method demonstrated rapid detection of OXA-like carbapenem resistance in A. baumannii in comparison with phenotypic susceptibility testing methodology. This method could be adapted to a multiplexed single reaction for rapid detection of genes associated with carbapenem resistance in A. baumannii and potentially other clinically significant multidrug-resistant Gram-negative bacteria. C1 [Huang, Xiao-Zhe; Cash, Dana M.; Chahine, Mohamad A.; Nikolich, Mikeljon P.; Craft, David W.] Walter Reed Army Inst Res, Bacterial Dis Branch, Silver Spring, MD 20910 USA. RP Huang, XZ (reprint author), Walter Reed Army Inst Res, Bacterial Dis Branch, Silver Spring, MD 20910 USA. EM xiaozhe.huang1.ctr@us.army.mil FU Military Infectious Diseases Research Program-Defense Health Program; US Department of Defense FX We thank Emil P. Lesho for valuable discussion and advice on antibiotic applications in clinical settings and Lisa Hochberg for providing technical advice on the SmartCycler PCR platform application. This work was funded by Military Infectious Diseases Research Program-Defense Health Program and the US Department of Defense. The findings and opinions expressed herein belong to the authors and do not necessarily reflect the official views of the Walter Reed Army Institute of Research, the US Army or the US Department of Defense. NR 20 TC 8 Z9 10 U1 0 U2 2 PU SOC GENERAL MICROBIOLOGY PI READING PA MARLBOROUGH HOUSE, BASINGSTOKE RD, SPENCERS WOODS, READING RG7 1AG, BERKS, ENGLAND SN 0022-2615 J9 J MED MICROBIOL JI J. Med. Microbiol. PD NOV PY 2012 VL 61 IS 11 BP 1532 EP 1537 DI 10.1099/jmm.0.045823-0 PG 6 WC Microbiology SC Microbiology GA 044BL UT WOS:000311594300006 PM 22878252 ER PT J AU Kheirabadi, BS Terrazas, IB Williams, JF Hanson, MA Dubick, MA Blackbourne, LH AF Kheirabadi, Bijan S. Terrazas, Irasema B. Williams, James F. Hanson, Margaret A. Dubick, Michael A. Blackbourne, Lorne H. TI Negative-pressure wound therapy: A hemostatic adjunct for control of coagulopathic hemorrhage in large soft tissue wounds SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY LA English DT Article DE Negative-pressure wound therapy; hemostatic adjunct; coagulopathy; swine ID VACUUM-ASSISTED CLOSURE; IMPROVING GRAFT-SURVIVAL; SECURING SKIN-GRAFTS; COMBAT CASUALTIES; TRAUMA; INJURIES; DEVICE; EXPERIENCE; MANAGEMENT; FRACTURES AB BACKGROUND: Negative-pressure wound therapy has been commonly used for treating chronic wounds and recently applied for treatment of traumatic wounds. We investigated the potential hemostatic benefit of negative-pressure wound therapy for control of refractory hemorrhage in a soft tissue wound model in swine. METHODS: Coagulopathy was induced in pigs (n = 38, 36 kg) by hemodilution and hypothermia. Next, a large soft tissue wound (diameter, approximately 20 cm) was created by slicing the gluteus maximus muscle. Free bleeding was allowed for 1 minute, and wounds were then randomly dressed with either laparotomy gauze (G) alone or TraumaPad (TP, a kaolin-coated dressing) alone or in combination with negative pressure (NP, approximately -500 mm Hg). All wounds were sealed with adhesive drapes. Fluid resuscitation was administered and targeted to mean arterial pressure of 60 mm Hg. Pigs were observed for 150 minutes or until death after which tissues were sampled for histologic examination. RESULTS: Induced coagulopathy as measured by increases in prothrombin time (12%) and activated partial thromboplastin time (22%) and decreases in fibrinogen (48%) were similar in all groups. There were no differences in initial bleeding rates (4.5 mL/kg/min). Dressing the wounds with G or TP produced hemostasis only in one pig (1 of 18 pigs). Addition of NP to these dressings secured hemostasis in 70% (G) and 90% (TP) of animals with average hemostasis time of 34 minutes and 25 minutes, respectively. Blood losses and fluid resuscitation requirements were significantly less, and survival times were significantly longer in NP adjunct groups than in the other groups. Survival rates were 80% (G+NP) and 90% (TP+NP) versus 0% (G) and 10% (TP) in the respective groups. Histologic examination showed similar superficial myofibril damages in all groups. CONCLUSION: To our knowledge, the present data provide the first evidence that NP serves as an effective hemostatic adjunct and when combined with standard hemostatic dressing it is able to stop lethal coagulopathic bleeding in large soft tissue wounds. (J Trauma Acute Care Surg. 2012; 73: 1188-1194. Copyright (c) 2012 by Lippincott Williams & Wilkins) C1 [Kheirabadi, Bijan S.; Terrazas, Irasema B.; Williams, James F.; Hanson, Margaret A.; Dubick, Michael A.; Blackbourne, Lorne H.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Kheirabadi, BS (reprint author), 3650 Chambers Pass,BHT2,Bldg 3610, Ft Sam Houston, TX 78234 USA. EM BIJAN.KHEIRABADI@US.ARMY.MIL FU US Army Medical Research and Materiel Command; Veterinary Support Branch FX We express our sincere gratitude to Dr. Harold Klemcke for his careful review and editorial assistance of the article. We also acknowledge our Veterinary Support Branch for their support and assistance in conducting these experiments. The excellent technical assistance by Dr. Adekoye Sanni (DVM), SPC Birk Greene, and SPC Alice Craig is greatly appreciated.; The funding for this work was provided solely by the US Army Medical Research and Materiel Command. NR 26 TC 2 Z9 2 U1 4 U2 9 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 2163-0755 J9 J TRAUMA ACUTE CARE JI J. Trauma Acute Care Surg. PD NOV PY 2012 VL 73 IS 5 BP 1188 EP 1194 DI 10.1097/TA.0b013e31826f98ea PG 7 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 043VF UT WOS:000311577100028 PM 23117379 ER PT J AU Edwards, MJ Lustik, M Eichelberger, MR Elster, E Azarow, K Coppola, C AF Edwards, Mary J. Lustik, Michael Eichelberger, Martin R. Elster, Eric Azarow, Kenneth Coppola, Christopher TI Blast injury in children: An analysis from Afghanistan and Iraq, 2002-2010 SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY LA English DT Article DE Explosive; children; combat; improvised explosive device; land mine ID PEDIATRIC TRAUMA; SEVERITY SCORE; MORTALITY AB BACKGROUND: Throughout history, children have been victims of armed conflict, including the blast injury complex, however, the pattern of injury, physiologic impact, and treatment needs of children with this injury are not well documented. METHODS: The Joint Theatre Trauma Registry provides data on all civilians admitted to US military treatment facilities from 2002 to 2010 with injuries from an explosive device. The data were stratified by age and analyzed for differences in anatomic injury patterns, Injury Severity Score (ISS), Revised Trauma Score (RTS), mortality, intensive care unit days, and length of hospitalization. Multivariate logistic regression was done to determine independent predictors of mortality. All operative procedures with a specified site were tabulated and categorized by body region and age. RESULTS: A total of 4,983 civilian patients were admitted, 25% of whom were younger than 15 years. Pediatric patients aged 8 to 14 years had a higher ISS and hospital stay than other age groups, and children younger than 15 years had a longer intensive care unit stay. Injuries in children were more likely to occur in the head and neck and less likely in the bony pelvis and extremities. Children had a lower RTS than the other age groups. Mortality correlated highly with burns, head injury, transfusion, and RTS. Adolescent patients had a lower mortality rate than the other age groups. Improvised explosive devices were the most common cause of injury in all age groups. CONCLUSION: Children experiencing blast injury complex have an anatomic pattern that is unique and an RTS that reflects more severe physiologic derangement. Injuries requiring transfusion or involving the head and neck and burns were predictive of mortality, and this persisted across all age groups. The mortality rate of children with blast injury is significant (7%), and treatment is resource intensive, requiring many surgical subspecialties. (J Trauma Acute Care Surg. 2012;73:1278-1283. Copyright (c) 2012 by Lippincott Williams & Wilkins) C1 [Edwards, Mary J.] Tripler Army Med Ctr, Dept Surg, Honolulu, HI 96859 USA. [Lustik, Michael] Tripler Army Med Ctr, Dept Clin Invest, Honolulu, HI 96859 USA. [Eichelberger, Martin R.] Childrens Natl Med Ctr, Dept Surg, Washington, DC 20010 USA. [Elster, Eric] Walter Reed Natl Mil Med Ctr, Dept Surg, Washington, DC USA. [Azarow, Kenneth] Univ Nebraska, Coll Med, Dept Surg, Childrens Hosp & Med Ctr, Omaha, NE 68198 USA. [Coppola, Christopher] Geisinger Med Ctr, Dept Surg, Danville, PA 17822 USA. RP Edwards, MJ (reprint author), Tripler Army Med Ctr, Dept Surg, Jarrett White Rd, Honolulu, HI 96859 USA. EM mary.j.edwards@us.army.mil OI Coppola, Christopher/0000-0002-2683-4324 FU Childress Institute for Pediatric Trauma at Wake Forest University Baptist Hospital in Winston-Salem, North Carolina FX The authors thank Ms. Janet Schadee and Ms. Susan West of the US Army Institute of Surgical Research and the entire staff of the Joint Theatre Trauma Registry for their assistance in collecting data for this article. The authors appreciate the support of the Childress Institute for Pediatric Trauma at Wake Forest University Baptist Hospital in Winston-Salem, North Carolina, and the research contributed by Lauren Waterhouse from the Children's National Medical Center in Washington, District of Columbia. NR 23 TC 14 Z9 17 U1 0 U2 7 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 2163-0755 J9 J TRAUMA ACUTE CARE JI J. Trauma Acute Care Surg. PD NOV PY 2012 VL 73 IS 5 BP 1278 EP 1283 DI 10.1097/TA.0b013e318270d3ee PG 6 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 043VF UT WOS:000311577100043 PM 23117384 ER PT J AU Hahm, MG Reddy, ALM Cole, DP Rivera, M Vento, JA Nam, J Jung, HY Kim, YL Narayanan, NT Hashim, DP Galande, C Jung, YJ Bundy, M Karna, S Ajayan, PM Vajtai, R AF Hahm, Myung Gwan Reddy, Arava Leela Mohana Cole, Daniel P. Rivera, Monica Vento, Joseph A. Nam, Jaewook Jung, Hyun Young Kim, Young Lae Narayanan, Narayanan T. Hashim, Daniel P. Galande, Charudatta Jung, Yung Joon Bundy, Mark Karna, Shashi Ajayan, Pulickel M. Vajtai, Robert TI Carbon Nanotube-Nanocup Hybrid Structures for High Power Supercapacitor Applications SO NANO LETTERS LA English DT Article DE Carbon nanotubes; carbon nanocups; energy storage; supercapacitor; high surface area ID ONION-LIKE CARBON; ELECTROCHEMICAL CAPACITORS; NANOPOROUS CARBON; RAMAN-SPECTROSCOPY; SURFACE-AREA; ELECTRODES; PERFORMANCE; BEHAVIOR; MODEL AB Here, we design and develop high-power electric double-layer capacitors (EDLCs) using carbon-based three dimensional (3-D) hybrid nanostructured electrodes. 3-D hybrid nanostructured electrodes consisting of vertically aligned carbon nanotubes (CNTs) on highly porous carbon nanocups (CNCs) were synthesized by a combination of anodization and chemical vapor deposition techniques. A 3-D electrode-based supercapacitor showed enhanced areal capacitance by accommodating more charges in a given footprint area than that of a conventional CNC-based device. C1 [Hahm, Myung Gwan; Reddy, Arava Leela Mohana; Narayanan, Narayanan T.; Hashim, Daniel P.; Galande, Charudatta; Ajayan, Pulickel M.; Vajtai, Robert] Rice Univ, Dept Mech Engn & Mat Sci, Houston, TX 77005 USA. [Hahm, Myung Gwan] Shinshu Univ, Res Ctr Exot Nanocarbons, Nagano 3808553, Japan. [Cole, Daniel P.; Rivera, Monica] Motile Robot Inc, Joppa, MD 21085 USA. [Vento, Joseph A.] Rice Univ, Dept Elect & Comp Engn, Houston, TX 77005 USA. [Nam, Jaewook] Sungkyunkwan Univ, Sch Chem Engn, Suwon 440746, Gyeonggi Do, South Korea. [Jung, Hyun Young; Jung, Yung Joon] Northeastern Univ, Dept Mech & Ind Engn, Boston, MA 02115 USA. [Kim, Young Lae] Northeastern Univ, Dept Elect & Comp Engn, Boston, MA 02115 USA. [Bundy, Mark; Karna, Shashi] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Hahm, MG (reprint author), Rice Univ, Dept Mech Engn & Mat Sci, Houston, TX 77005 USA. EM mghahm@shinshu-u.ac.jp; ajayan@rice.edu; Robert.Vajtai@rice.edu RI Hashim, Daniel/H-1694-2013; Hahm, Myung Gwan/D-6789-2011; Jung, Yung Joon/L-2032-2013; Arava, Leela Mohana Reddy/J-3180-2015 OI Hahm, Myung Gwan/0000-0002-6432-0578; FU U.S. Army Research Laboratory/Army Research Office [W911NF]; Exotic Nanocarbons, Japan Regional Innovation Strategy Program by the Excellence, JST; Army Research Office; Nano Japan; NSF; Rice University; U.S. Department of Defense: U.S. Air Force Office of Scientific Research [FA9550-12-1-0035]; NSF [0940902]; Ministry of Knowledge Economy, Republic of Korea FX M.G.H., RV., and P.M.A. acknowledge financial support from U.S. Army Research Laboratory/Army Research Office (No. W911NF). M.G.H. and P.M.A. acknowledge the support from Exotic Nanocarbons, Japan Regional Innovation Strategy Program by the Excellence, JST. A.L.M.R. acknowledge funding support from the Army Research Office. J.A.V. and P.M.A. acknowledge financial support from Nano Japan program sponsored by the NSF and Rice University. T.N.N. and P.M.A. acknowledge funding sponsorship from the U.S. Department of Defense: U.S. Air Force Office of Scientific Research for the Project MURI: "Synthesis and Characterization of 3-D Carbon Nanotube Solid Networks" award no.: FA9550-12-1-0035. D.P.H. is grateful to the NSF for the Graduate Research Fellowship award grant no. 0940902. Y.J.J. acknowledges the financial support from Fundamental R&D Program for Core Technology of Materials in the Ministry of Knowledge Economy, Republic of Korea. In addition, M.G.H. acknowledges the technical advice on setting the electrochemical cell from Dr. Bon-Cheol Ku at the Korea Institute of Science and Technology. NR 35 TC 84 Z9 84 U1 18 U2 211 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1530-6984 J9 NANO LETT JI Nano Lett. PD NOV PY 2012 VL 12 IS 11 BP 5616 EP 5621 DI 10.1021/nl3027372 PG 6 WC Chemistry, Multidisciplinary; Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied; Physics, Condensed Matter SC Chemistry; Science & Technology - Other Topics; Materials Science; Physics GA 039KJ UT WOS:000311244400029 PM 23030825 ER PT J AU Knight, MW Liu, LF Wang, YM Brown, L Mukherjee, S King, NS Everitt, HO Nordlander, P Halas, NJ AF Knight, Mark W. Liu, Lifei Wang, Yumin Brown, Lisa Mukherjee, Shaunak King, Nicholas S. Everitt, Henry O. Nordlander, Peter Halas, Naomi J. TI Aluminum Plasmonic Nanoantennas SO NANO LETTERS LA English DT Article DE Plasmon; UV; cathodoluminescence; nanoparticle; nanorod; aluminum ID RAMAN-SCATTERING; CATHODOLUMINESCENCE; NANOPARTICLES; SPECTROSCOPY; EXCITATIONS; ULTRAVIOLET; NANOSPHERES; PARTICLES; SILVER; GOLD AB The use of aluminum for plasmonic nanostructures opens up new possibilities, such as access to short-wavelength regions of the spectrum, complementary metal-oxide-semiconductor (CMOS) compatibility, and the possibility of sustainable, mass-producible plasmonic materials Here we examine the properties of individual Al nanorod antennas with cathodoluminescence (CL). This approach allows us to image the local density of optical states (LDOS) of Al nanorod antennas with a spatial resolution less than 20 nm and to identify the radiative modes of these nanostructures across the visible and into the UV spectral range. The results, which agree well with finite difference time domain (FDTD) simulations, lay the groundwork for precise Al plasmonic nanostructure design for a variety of applications. C1 [Knight, Mark W.; Wang, Yumin; Nordlander, Peter; Halas, Naomi J.] Rice Univ, Dept Elect & Comp Engn, Houston, TX 77005 USA. [Liu, Lifei; King, Nicholas S.; Nordlander, Peter; Halas, Naomi J.] Rice Univ, Dept Phys & Astron, Houston, TX 77005 USA. [Brown, Lisa; Mukherjee, Shaunak; Halas, Naomi J.] Rice Univ, Dept Chem, Houston, TX 77005 USA. [Knight, Mark W.; Liu, Lifei; Wang, Yumin; Brown, Lisa; Mukherjee, Shaunak; King, Nicholas S.; Nordlander, Peter; Halas, Naomi J.] Rice Univ, Lab Nanophoton, Houston, TX 77005 USA. [Everitt, Henry O.] USA, Charles Bowden Res Lab, Aviat & Missile RD&E Ctr, Redstone Arsenal, AL 35898 USA. [Everitt, Henry O.] Duke Univ, Dept Phys, Durham, NC 27708 USA. RP Halas, NJ (reprint author), Rice Univ, Dept Elect & Comp Engn, Houston, TX 77005 USA. EM halas@rice.edu RI Knight, Mark/E-3089-2010; King, Nicholas/F-8540-2011; Everitt, Henry/L-7118-2013; Wang, Yumin/C-9551-2014; Liu, Lifei/H-4034-2015; Nordlander, Peter/A-2560-2008; Halas, Naomi/D-2935-2011 OI Knight, Mark/0000-0001-7625-403X; Everitt, Henry/0000-0002-8141-3768; Nordlander, Peter/0000-0002-1633-2937; FU Robert A. Welch Foundation [C-1220, C-1222]; National Security Science and Engineering Faculty Fellowship (NSSEFF) [N00244-09-1-0067]; Air Force Office of Scientific Research (AFOSR) [FA9550-10-1-0469]; NSF MRI; Army's in-house laboratory independent research program; Army Research Office FX The authors would like to acknowledge Tim Gilheart, Kung-Po Chao, Sandra Bishnoi, Alex Urban, Jared Day, John Foreman, and Surbhi Lal for productive discussions. This work was supported by the Robert A. Welch Foundation under Grants C-1220 (N.J.H.) and C-1222 (P.N.), the National Security Science and Engineering Faculty Fellowship (NSSEFF) N00244-09-1-0067, the Air Force Office of Scientific Research (AFOSR) FA9550-10-1-0469, NSF MRI, the Army's in-house laboratory independent research program, and the Army Research Office. NR 28 TC 207 Z9 209 U1 24 U2 280 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1530-6984 J9 NANO LETT JI Nano Lett. PD NOV PY 2012 VL 12 IS 11 BP 6000 EP 6004 DI 10.1021/nl303517v PG 5 WC Chemistry, Multidisciplinary; Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied; Physics, Condensed Matter SC Chemistry; Science & Technology - Other Topics; Materials Science; Physics GA 039KJ UT WOS:000311244400096 PM 23072330 ER PT J AU Levy, JA Farber, GL Taylor, KF AF Levy, Jeffrey A. Farber, Gerald L. Taylor, Kenneth F. TI Novel Technique for Passing Tendon Grafts Through Bone Tunnels SO ORTHOPEDICS LA English DT Editorial Material ID METACARPOPHALANGEAL JOINT; INSTABILITY; THUMB AB Anatomic reconstruction in orthopedic surgery often requires the passage of soft tissue through bone tunnels. Difficulties may arise due to anatomic constraints surrounding the bone tunnels or the graft size. The authors present a novel technique for passing tendon grafts through bone tunnels that is simple, readily available, effective, and comparatively inexpensive. C1 [Taylor, Kenneth F.] Penn State Milton S Hershey Med Ctr, Dept Orthopaed & Rehabil, Hershey, PA 17033 USA. [Levy, Jeffrey A.; Farber, Gerald L.] Tripler Army Med Ctr, Orthopaed Surg Serv, Honolulu, HI 96859 USA. RP Taylor, KF (reprint author), Penn State Milton S Hershey Med Ctr, Dept Orthopaed & Rehabil, 30 Hope Dr,POB 859, Hershey, PA 17033 USA. EM ktaylor3@hmc.psu.edu NR 4 TC 0 Z9 0 U1 0 U2 0 PU SLACK INC PI THOROFARE PA 6900 GROVE RD, THOROFARE, NJ 08086 USA SN 0147-7447 J9 ORTHOPEDICS JI Orthopedics PD NOV PY 2012 VL 35 IS 11 BP 944 EP 946 DI 10.3928/01477447-20121023-04 PG 3 WC Orthopedics SC Orthopedics GA 036NB UT WOS:000311031900027 PM 23127438 ER PT J AU Karamian, SA Carroll, JJ AF Karamian, S. A. Carroll, J. J. TI Calculated yield of isomer depletion due to NEEC for Mo-93m recoils SO PHYSICS OF ATOMIC NUCLEI LA English DT Article ID ELECTRON-CAPTURE AB In the present work, quantitative calculations were carried out for production and depletion of the (93m) Mo isomer in a relatively simple experiment using Zr-91 beam ions. Such studies could be arranged at existing and operating accelerator facilities, e.g. at GSI or in JINR. The (93m) Mo nuclei produced in a He gas target due to the He-4(Zr-91, 2n) reaction will recoil into a gas stopper with a high velocity, being then depleted due to NEEC in highly-ionized species. C1 [Karamian, S. A.] Joint Inst Nucl Res, Dubna, Russia. [Carroll, J. J.] USA, Res Lab, Adelphi, MD USA. RP Karamian, SA (reprint author), Joint Inst Nucl Res, Dubna, Russia. EM karamian@nrmail.jinr.ru NR 14 TC 1 Z9 1 U1 3 U2 7 PU MAIK NAUKA/INTERPERIODICA/SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013-1578 USA SN 1063-7788 J9 PHYS ATOM NUCL+ JI Phys. Atom. Nuclei PD NOV PY 2012 VL 75 IS 11 BP 1362 EP 1367 DI 10.1134/S1063778812110117 PG 6 WC Physics, Nuclear; Physics, Particles & Fields SC Physics GA 038WD UT WOS:000311203900007 ER PT J AU Ahmed, SA Awosika, J Baldwin, C Bishop-Lilly, KA Biswas, B Broomall, S Chain, PSG Chertkov, O Chokoshvili, O Coyne, S Davenport, K Detter, JC Dorman, W Erkkila, TH Folster, JP Frey, KG George, M Gleasner, C Henry, M Hill, KK Hubbard, K Insalaco, J Johnson, S Kitzmiller, A Krepps, M Lo, CC Luu, T McNew, LA Minogue, T Munk, CA Osborne, B Patel, M Reitenga, KG Rosenzweig, CN Shea, A Shen, XH Strockbine, N Tarr, C Teshima, H van Gieson, E Verratti, K Wolcott, M Xie, G Sozhamannan, S Gibbons, HS AF Ahmed, Sanaa A. Awosika, Joy Baldwin, Carson Bishop-Lilly, Kimberly A. Biswas, Biswajit Broomall, Stacey Chain, Patrick S. G. Chertkov, Olga Chokoshvili, Otar Coyne, Susan Davenport, Karen Detter, J. Chris Dorman, William Erkkila, Tracy H. Folster, Jason P. Frey, Kenneth G. George, Matroner Gleasner, Cheryl Henry, Matthew Hill, Karen K. Hubbard, Kyle Insalaco, Joseph Johnson, Shannon Kitzmiller, Aaron Krepps, Michael Lo, Chien-Chi Truong Luu McNew, Lauren A. Minogue, Timothy Munk, Christine A. Osborne, Brian Patel, Mohit Reitenga, Krista G. Rosenzweig, C. Nicole Shea, April Shen, Xiaohong Strockbine, Nancy Tarr, Cheryl Teshima, Hazuki van Gieson, Eric Verratti, Kathleen Wolcott, Mark Xie, Gary Sozhamannan, Shanmuga Gibbons, Henry S. CA Threat Characterization Consortium TI Genomic Comparison of Escherichia coli O104:H4 Isolates from 2009 and 2011 Reveals Plasmid, and Prophage Heterogeneity, Including Shiga Toxin Encoding Phage stx2 SO PLOS ONE LA English DT Article ID HEMOLYTIC-UREMIC SYNDROME; SALMONELLA-TYPHIMURIUM; AGGREGATIVE ADHERENCE; GADE YHIE; BACTERIOPHAGES; RESISTANCE; PATHOGENS; SEQUENCES; ALIGNMENT; OUTBREAK AB In May of 2011, an enteroaggregative Escherichia coli O104:H4 strain that had acquired a Shiga toxin 2-converting phage caused a large outbreak of bloody diarrhea in Europe which was notable for its high prevalence of hemolytic uremic syndrome cases. Several studies have described the genomic inventory and phylogenies of strains associated with the outbreak and a collection of historical E. coli O104: H4 isolates using draft genome assemblies. We present the complete, closed genome sequences of an isolate from the 2011 outbreak (2011C-3493) and two isolates from cases of bloody diarrhea that occurred in the Republic of Georgia in 2009 (2009EL-2050 and 2009EL-2071). Comparative genome analysis indicates that, while the Georgian strains are the nearest neighbors to the 2011 outbreak isolates sequenced to date, structural and nucleotide-level differences are evident in the Stx2 phage genomes, the mer/tet antibiotic resistance island, and in the prophage and plasmid profiles of the strains, including a previously undescribed plasmid with homology to the pMT virulence plasmid of Yersinia pestis. In addition, multiphenotype analysis showed that 2009EL-2071 possessed higher resistance to polymyxin and membrane-disrupting agents. Finally, we show evidence by electron microscopy of the presence of a common phage morphotype among the European and Georgian strains and a second phage morphotype among the Georgian strains. The presence of at least two stx2 phage genotypes in host genetic backgrounds that may derive from a recent common ancestor of the 2011 outbreak isolates indicates that the emergence of stx2 phage-containing E. coli O104: H4 strains probably occurred more than once, or that the current outbreak isolates may be the result of a recent transfer of a new stx2 phage element into a pre-existing stx2-positive genetic background. C1 [Broomall, Stacey; Hubbard, Kyle; Insalaco, Joseph; Krepps, Michael; McNew, Lauren A.; Rosenzweig, C. Nicole; Gibbons, Henry S.] USA, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD USA. [Ahmed, Sanaa A.; Chain, Patrick S. G.; Chertkov, Olga; Davenport, Karen; Detter, J. Chris; Erkkila, Tracy H.; Gleasner, Cheryl; Hill, Karen K.; Johnson, Shannon; Lo, Chien-Chi; Munk, Christine A.; Reitenga, Krista G.; Shen, Xiaohong; Teshima, Hazuki; Xie, Gary] Los Alamos Natl Lab, Los Alamos, NM USA. [Awosika, Joy; Bishop-Lilly, Kimberly A.; Biswas, Biswajit; Frey, Kenneth G.; George, Matroner; Henry, Matthew; Truong Luu; Patel, Mohit; Verratti, Kathleen; Sozhamannan, Shanmuga] USN, Med Res Ctr, Frederick, MD USA. [Awosika, Joy; Bishop-Lilly, Kimberly A.; Biswas, Biswajit; Frey, Kenneth G.; George, Matroner; Henry, Matthew; Truong Luu; Patel, Mohit; Verratti, Kathleen; Sozhamannan, Shanmuga] Henry M Jackson Fdn Mil Med, Frederick, MD USA. [Baldwin, Carson; Coyne, Susan; Dorman, William; Minogue, Timothy; Shea, April; Wolcott, Mark] USA, Res Inst Infect Dis, Frederick, MD USA. [Chokoshvili, Otar] Natl Ctr Dis Control & Publ Hlth, S Caucasus Field Epidemiol & Lab Training Program, Tbilisi, Rep of Georgia. [Folster, Jason P.; Strockbine, Nancy; Tarr, Cheryl] Ctr Dis Control & Prevent, Enter Dis Lab Branch, Atlanta, GA USA. [Hubbard, Kyle; Krepps, Michael] Excet Inc, Springfield, VA USA. [Insalaco, Joseph] Sci Applicat Int Corp, Abingdon, MD USA. [Kitzmiller, Aaron; Osborne, Brian] BioTeam Inc, Middleton, MA USA. [Shea, April] Team Keaki Tech, Frederick, MD USA. [van Gieson, Eric] Def Threat Reduct Agcy, Alexandria, VA USA. RP Gibbons, HS (reprint author), USA, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD USA. EM henry.s.gibbons.civ@mail.mil RI chain, patrick/B-9777-2013; OI Johnson, Shannon/0000-0002-3972-9208; Chain, Patrick/0000-0003-3949-3634; xie, gary/0000-0002-9176-924X FU Defense Threat Reduction Agency [CB2847, IB06RSQ002] FX The work presented here was supported by the Defense Threat Reduction Agency (www.dtra.mil) Transformational Medical Technologies program under project numbers CB2847 to HSG and CNR; IB06RSQ002 to SS; and to JCD. The funding agency participated in the formation of the consortium but did not impact the collection of data, analysis, decision to publish, or preparation of the manuscript. NR 90 TC 37 Z9 39 U1 1 U2 36 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD NOV 1 PY 2012 VL 7 IS 11 AR e48228 DI 10.1371/journal.pone.0048228 PG 22 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 030WR UT WOS:000310601300006 PM 23133618 ER PT J AU Krishnan, A Miller, EH Herbert, AS Ng, M Ndungo, E Whelan, SP Dye, JM Chandran, K AF Krishnan, Anuja Miller, Emily Happy Herbert, Andrew S. Ng, Melinda Ndungo, Esther Whelan, Sean P. Dye, John M. Chandran, Kartik TI Niemann-Pick C1 (NPC1)/NPC1-like1 Chimeras Define Sequences Critical for NPC1's Function as a Filovirus Entry Receptor SO VIRUSES-BASEL LA English DT Article DE Ebola virus; Marburg virus; filovirus; viral entry; Niemann-Pick C1; NPC1; Niemann-Pick C1-like1; NPC1L1; host factor; viral receptor ID EBOLA-VIRUS GLYCOPROTEIN; CHOLESTEROL ABSORPTION; MEMBRANE-FUSION; INFECTION; PROTEIN; IDENTIFICATION; REQUIRES; ANTIBODY; COMPLEX; FAMILY AB We recently demonstrated that Niemann-Pick C1 (NPC1), a ubiquitous 13-pass cellular membrane protein involved in lysosomal cholesterol transport, is a critical entry receptor for filoviruses. Here we show that Niemann-Pick C1-like1 (NPC1L1), an NPC1 paralog and hepatitis C virus entry factor, lacks filovirus receptor activity. We exploited the structural similarity between NPC1 and NPC1L1 to construct and analyze a panel of chimeras in which NPC1L1 sequences were replaced with cognate sequences from NPC1. Only one chimera, NPC1L1 containing the second luminal domain (C) of NPC1 in place of its own, bound to the viral glycoprotein, GP. This engineered protein mediated authentic filovirus infection nearly as well as wild-type NPC1, and more efficiently than did a minimal NPC1 domain C-based receptor recently described by us. A reciprocal chimera, NPC1 containing NPC1L1's domain C, was completely inactive. Remarkably, an intra-domain NPC1L1-NPC1 chimera bearing only a similar to 130-amino acid N-terminal region of NPC1 domain C could confer substantial viral receptor activity on NPC1L1. Taken together, these findings account for the failure of NPC1L1 to serve as a filovirus receptor, highlight the central role of the luminal domain C of NPC1 in filovirus entry, and reveal the direct involvement of N-terminal domain C sequences in NPC1's function as a filovirus receptor. C1 [Krishnan, Anuja; Miller, Emily Happy; Ng, Melinda; Ndungo, Esther; Chandran, Kartik] Yeshiva Univ Albert Einstein Coll Med, Dept Microbiol & Immunol, Bronx, NY 10461 USA. [Herbert, Andrew S.; Dye, John M.] USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. [Whelan, Sean P.] Harvard Univ, Sch Med, Dept Microbiol & Immunobiol, Boston, MA 02115 USA. [Krishnan, Anuja] Inst Mol Med, New Delhi 110020, India. RP Chandran, K (reprint author), Yeshiva Univ Albert Einstein Coll Med, Dept Microbiol & Immunol, 1300 Morris Pk Ave, Bronx, NY 10461 USA. EM anuja@immindia.org; emily.miller@med.einstein.yu.edu; andrew.s.herbert@us.army.mil; melinda.ng@phd.einstein.yu.edu; esther.ndungo@phd.einstein.yu.edu; sean.whelan@hms.harvard.edu; john.m.dye1@us.army.mil; kartik.chandran@einstein.yu.edu OI Ndungo, Esther/0000-0002-9975-7032 FU NIH [R01 AI101436, AI081842, U54 AI057159]; DTRA project [CBM.VAXPLAT.05.10.RD.005]; Indo-US Science and Technology Forum fellowship; NIH-funded training program at the Albert Einstein College of Medicine [T32 GM007288] FX We thank Rohini G. Sandesara for excellent technical assistance. We also thank T.-Y. Chang and D.R. Burton for their generous gifts of the NPC1-null CHO CT43 cells and KZ52 antibody, respectively. This research was supported by NIH grants R01 AI101436 (to K.C.), AI081842 and U54 AI057159 (NERCE-BEID) (to S.P.W.); and by the DTRA project, #CBM.VAXPLAT.05.10.RD.005 (to J.M.D.). A.K. was additionally supported by an Indo-US Science and Technology Forum fellowship. E.H.M. was additionally supported by NIH-funded training program T32 GM007288 at the Albert Einstein College of Medicine. Opinions, interpretations, conclusions, and recommendations are those of the authors and are not necessarily endorsed by the U.S. Army. NR 34 TC 18 Z9 19 U1 0 U2 6 PU MDPI AG PI BASEL PA POSTFACH, CH-4005 BASEL, SWITZERLAND SN 1999-4915 J9 VIRUSES-BASEL JI Viruses-Basel PD NOV PY 2012 VL 4 IS 11 BP 2471 EP 2484 DI 10.3390/v4112471 PG 14 WC Virology SC Virology GA 041VS UT WOS:000311429900004 PM 23202491 ER PT J AU Iversen, PL Warren, TK Wells, JB Garza, NL Mourich, DV Welch, LS Panchal, RG Bavari, S AF Iversen, Patrick L. Warren, Travis K. Wells, Jay B. Garza, Nicole L. Mourich, Dan V. Welch, Lisa S. Panchal, Rekha G. Bavari, Sina TI Discovery and Early Development of AVI-7537 and AVI-7288 for the Treatment of Ebola Virus and Marburg Virus Infections SO VIRUSES-BASEL LA English DT Article DE Ebola; Marburg; Phosphorodiamidate Morpholino Oligomer; PMOplus; Therapeutic; Antiviral ID PHOSPHORODIAMIDATE MORPHOLINO OLIGOMER; ENTERICA SEROVAR TYPHIMURIUM; CELL-PENETRATING PEPTIDES; AMINO-ACID-COMPOSITION; RIBOSOME ENTRY SITE; ESCHERICHIA-COLI; TISSUE-CULTURE; C-MYC; ANTISENSE OLIGOMERS; HEMORRHAGIC-FEVER AB There are no currently approved treatments for filovirus infections. In this study we report the discovery process which led to the development of antisense Phosphorodiamidate Morpholino Oligomers (PMOs) AVI-6002 (composed of AVI-7357 and AVI-7539) and AVI-6003 (composed of AVI-7287 and AVI-7288) targeting Ebola virus and Marburg virus respectively. The discovery process involved identification of optimal transcript binding sites for PMO based RNA-therapeutics followed by screening for effective viral gene target in mouse and guinea pig models utilizing adapted viral isolates. An evolution of chemical modifications were tested, beginning with simple Phosphorodiamidate Morpholino Oligomers (PMO) transitioning to cell penetrating peptide conjugated PMOs (PPMO) and ending with PMOplus containing a limited number of positively charged linkages in the PMO structure. The initial lead compounds were combinations of two agents targeting separate genes. In the final analysis, a single agent for treatment of each virus was selected, AVI-7537 targeting the VP24 gene of Ebola virus and AVI-7288 targeting NP of Marburg virus, and are now progressing into late stage clinical development as the optimal therapeutic candidates. C1 [Iversen, Patrick L.; Mourich, Dan V.] Sarepta Therapeut, Bothell, WA 98021 USA. [Warren, Travis K.; Wells, Jay B.; Garza, Nicole L.; Welch, Lisa S.; Panchal, Rekha G.; Bavari, Sina] USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. RP Iversen, PL (reprint author), Sarepta Therapeut, Bothell, WA 98021 USA. EM piversen@sareptatherapeutics.com; Tracis.K.Warren@us.army.mil; Jay.B.Wells@us.army.mil; Nicole.garza@us.army.mil; dmourich@sareptatherapeutics.com; lisa.s.welch@us.army.mil; Rekha.Panchal@us.army.mil; bavaris@ncifcrf.gov FU Joint Project Manager-Transformational Medical Technologies FX This work was supported by multiple contracts to AVI BioPharma by the Joint Project Manager-Transformational Medical Technologies. NR 54 TC 50 Z9 53 U1 2 U2 37 PU MDPI AG PI BASEL PA POSTFACH, CH-4005 BASEL, SWITZERLAND SN 1999-4915 J9 VIRUSES-BASEL JI Viruses-Basel PD NOV PY 2012 VL 4 IS 11 BP 2806 EP 2830 DI 10.3390/v4112806 PG 25 WC Virology SC Virology GA 041VS UT WOS:000311429900019 PM 23202506 ER PT J AU Kiesling, EC AF Kiesling, Eugenia C. TI Enduring Battle: American Soldiers in Three Wars, 1776-1945 SO WAR IN HISTORY LA English DT Book Review C1 [Kiesling, Eugenia C.] US Mil Acad, West Point, NY 10996 USA. RP Kiesling, EC (reprint author), US Mil Acad, West Point, NY 10996 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU SAGE PUBLICATIONS LTD PI LONDON PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND SN 0968-3445 J9 WAR HIST JI War Hist. PD NOV PY 2012 VL 19 IS 4 BP 517 EP 519 PG 3 WC History; International Relations SC History; International Relations GA 034OZ UT WOS:000310884100005 ER PT J AU Thorsley, D Leproult, R Spiegel, K Reifman, J AF Thorsley, David Leproult, Rachel Spiegel, Karine Reifman, Jaques TI A phenomenological model for circadian and sleep allostatic modulation of plasma cortisol concentration SO AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM LA English DT Article DE biomathematical models; hypothalamo-pituitary-adrenal axis; sleep loss ID POSTTRAUMATIC-STRESS-DISORDER; PITUITARY-ADRENAL AXIS; SECRETION; DEPRIVATION; RHYTHM; HOMEOSTASIS; FREQUENCY; PATTERNS; RELEASE; SHIFT AB Both circadian rhythmicity and sleep play significant roles in the regulation of plasma cortisol concentration by the hypothalamo-pituitary-adrenal (HPA) axis. Numerous studies have found links between sleep and changes in cortisol concentration, but the implications of these results have remained largely qualitative. In this article, we present a quantitative phenomenological model to describe the effects of different sleep durations on cortisol concentration. We constructed the proposed model by incorporating the circadian and sleep allostatic effects on cortisol concentration, the pulsatile nature of cortisol secretion, and cortisol's negative autoregulation of its own production and validated its performance on three study groups that experienced four distinct sleep durations. The model captured many disparate effects of sleep on cortisol dynamics, such as the inhibition of cortisol secretion after the wake-to-sleep transition and the rapid rise of cortisol concentration before morning awakening. Notably, the model reconciled the seemingly contradictory findings between studies that report an increase in cortisol concentration following total sleep deprivation and studies that report no change in concentration. This work provides a biomathematical approach to combine the results on the effects of sleep on cortisol concentration into a unified framework and predict the impact of varying sleep durations on the cortisol profile. C1 [Thorsley, David; Reifman, Jaques] USA, Med Res & Mat Command, Telemed & Adv Technol Res Ctr, Dept Def,Biotechnol High Performance Comp Softwar, Ft Detrick, MD 21702 USA. [Leproult, Rachel] Univ Chicago, Dept Med, Chicago, IL 60637 USA. [Leproult, Rachel] Univ Libre Brussels, Dept Psychol, Neuropsychol & Funct Neuroimaging Res Unit, Brussels, Belgium. [Spiegel, Karine] Univ Lyon 1, Ctr Rech Neurosci Lyon, Inst Natl Sante & Rech Med, U1028,Unite Mixte Rech 5292, F-69365 Lyon, France. RP Reifman, J (reprint author), USA, Med Res & Mat Command, Telemed & Adv Technol Res Ctr, Dept Def,Biotechnol High Performance Comp Softwar, 504 Scott St, Ft Detrick, MD 21702 USA. EM jaques.reifman@us.army.mil FU Military Operational Medicine Research Area Directorate of the US Army Medical Research and Materiel Command, Ft. Detrick, MD; Eve Van Cauter, Department of Medicine, University of Chicago FX We acknowledge the support of Eve Van Cauter, Department of Medicine, University of Chicago.; D. Thorsley and J. Reifman were funded in part by the Military Operational Medicine Research Area Directorate of the US Army Medical Research and Materiel Command, Ft. Detrick, MD. NR 40 TC 5 Z9 5 U1 0 U2 13 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 0193-1849 EI 1522-1555 J9 AM J PHYSIOL-ENDOC M JI Am. J. Physiol.-Endocrinol. Metab. PD NOV PY 2012 VL 303 IS 10 BP E1190 EP E1201 DI 10.1152/ajpendo.00271.2012 PG 12 WC Endocrinology & Metabolism; Physiology SC Endocrinology & Metabolism; Physiology GA 039EU UT WOS:000311227700002 PM 23011061 ER PT J AU Nindl, BC Urso, ML Pierce, JR Scofield, DE Barnes, BR Kraemer, WJ Anderson, JM Maresh, CM Beasley, KN Zambraski, EJ AF Nindl, Bradley C. Urso, Maria L. Pierce, Joseph R. Scofield, Dennis E. Barnes, Brian R. Kraemer, William J. Anderson, Jeffrey M. Maresh, Carl M. Beasley, Kathleen N. Zambraski, Edward J. TI IGF-I measurement across blood, interstitial fluid, and muscle biocompartments following explosive, high-power exercise SO AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY LA English DT Article DE growth signaling; hypertrophy; mechanical stress; skeletal muscle ID GROWTH-FACTOR-I; HEAVY-RESISTANCE EXERCISE; HUMAN SKELETAL-MUSCLE; MAJOR PHYSIOLOGICAL REGULATOR; PHYSICAL-FITNESS; BODY-COMPOSITION; SERUM HORMONES; MESSENGER-RNA; WOMEN; HYPERTROPHY AB Nindl BC, Urso ML, Pierce JR, Scofield DE, Barnes BR, Kraemer WJ, Anderson JM, Maresh CM, Beasley KN, Zambraski EJ. IGF-I measurement across blood, interstitial fluid, and muscle biocompartments following explosive, high-power exercise. Am J Physiol Regul Integr Comp Physiol 303: R1080-R1089, 2012. First published August 29, 2012; doi:10.1152/ajpregu.00275.2012.-Insulin-like growth factor-I (IGF-I) resides across different biocompartments [blood, interstitial fluid (ISF), and muscle]. Whether circulating IGF-I responses to exercise reflect local events remains uncertain. We measured the IGF-I response to plyometric exercise across blood, ISF, and muscle biopsy from the vastus lateralis. Twenty volunteers (8 men, 12 women, 22 +/- 1 yr) performed 10 sets of 10 plyometric jump repetitions at a 40% 1-repetition maximum. Blood, ISF, and muscle samples were taken pre- and postexercise. Circulating IGF-I increased postexercise: total IGF-I (preexercise = 546 +/- 42, midexercise = 585 +/- 43, postexercise = 597 +/- 45, +30 = 557 +/- 42, +60 = 536 +/- 40, +120 = 567 +/- 42 ng/ml; midexercise, postexercise, and +120 greater than preexercise, P < 0.05); Free IGF-I (preexercise = 0.83 +/- 0.09, midexercise = 0.78 +/- 0.10, postexercise = 0.79 +/- 0.11, +30 +/- 0.93 +/- 0.10, +60 = 0.88 +/- 0.10, +120 = 0.91 +/- 0.11 ng/ml; +30 greater than all other preceding time points, P < 0.05). No exercise-induced changes were observed for ISF IGF-I (preexercise = 2.35 +/- 0.29, postexercise = 2.46 +/- 0.35 ng/ml). No changes were observed for skeletal muscle IGF-I protein, although IGF-I mRNA content increased similar to 40% postexercise. The increase in circulating total and free IGF-I was not correlated with increases in ISF IGF-I or muscle IGF-I protein content. Our data indicate that exercise-induced increases in circulating IGF-I are not reflective of local IGF-I signaling. C1 [Nindl, Bradley C.; Urso, Maria L.; Pierce, Joseph R.; Scofield, Dennis E.; Barnes, Brian R.; Beasley, Kathleen N.; Zambraski, Edward J.] USA, Environm Med Res Inst, Mil Performance Div, Natick, MA 01760 USA. [Kraemer, William J.; Anderson, Jeffrey M.; Maresh, Carl M.] Univ Connecticut, Human Performance Lab, Dept Kinesiol, Storrs, CT USA. RP Nindl, BC (reprint author), USA, Inst Publ Hlth, Army Publ Hlth Command, Aberdeen Proving Ground, MD 21010 USA. EM bradley.nindl@us.army.mil RI SCOFIELD, DENNIS/F-3636-2015; OI Urso, Maria/0000-0001-8906-4673 NR 42 TC 6 Z9 6 U1 0 U2 6 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 0363-6119 J9 AM J PHYSIOL-REG I JI Am. J. Physiol.-Regul. Integr. Comp. Physiol. PD NOV PY 2012 VL 303 IS 10 BP R1080 EP R1089 DI 10.1152/ajpregu.00275.2012 PG 10 WC Physiology SC Physiology GA 039DW UT WOS:000311225000011 PM 22933025 ER PT J AU Mirza, RA Spillane, EL Thomas, B AF Mirza, Raul Alexander Spillane, Erin L. Thomas, Brian TI What Is Your Diagnosis? SO CUTIS LA English DT Editorial Material ID PRESSURE ALOPECIA; SURGERY C1 [Spillane, Erin L.] Womack Army Med Ctr, Dept Dermatol, Ft Bragg, NC 28307 USA. [Mirza, Raul Alexander; Thomas, Brian] Walter Reed Army Natl Mil Med Ctr, Bethesda, MD USA. RP Spillane, EL (reprint author), Womack Army Med Ctr, Dept Dermatol, Ft Bragg, NC 28307 USA. NR 5 TC 2 Z9 3 U1 0 U2 0 PU QUADRANT HEALTHCOM INC PI PARSIPPANY PA 7 CENTURY DRIVE, STE 302, PARSIPPANY, NJ 07054-4603 USA SN 0011-4162 J9 CUTIS JI Cutis PD NOV PY 2012 VL 90 IS 5 BP 224 EP + PG 2 WC Dermatology SC Dermatology GA 038QR UT WOS:000311189700003 PM 23270189 ER PT J AU Sheridan, RL Neely, AN Castillo, MA Shankowsky, HA Fagan, SP Chung, KK Weber, JM AF Sheridan, Robert L. Neely, Alice N. Castillo, Mayra A. Shankowsky, Heather A. Fagan, Shawn P. Chung, Kevin K. Weber, Joan M. TI A Survey of Invasive Catheter Practices in U.S. Burn Centers SO JOURNAL OF BURN CARE & RESEARCH LA English DT Article ID CRITICALLY-ILL; INFECTIONS AB Burn-specific guidelines for optimal catheter rotation, catheter type, insertion methods, and catheter site care do not exist, and practices vary widely from one burn unit to another. The purpose of this study was to define current practices and identify areas of practice variation for future clinical investigation. An online survey was sent to the directors of 123 U. S. burn centers. The survey consisted of 23 questions related to specific practices in placement and maintenance of central venous catheters (CVCs), arterial catheters, and peripherally inserted central catheters (PICCs). The overall response rate was 36%; response rate from verified centers was 52%. Geographic representation was wide. CVC and arterial catheter replacement varied from every 3 days (24% of sites) to only for overt infection (24% of sites); 23% of sites did not use the femoral position for CVC placement. Nearly 60% of units used some kind of antiseptic catheter. Physicians inserted the majority of catheters, and 22% of sites used nonphysicians for at least some insertions. Ultrasound was routinely used by less than 50% of units. A wide variety of post-insertion dressing protocols were followed. PICCs were used in some critically injured patients in 37% of units; the majority of these users did not rotate PICCs. Thus, it can be surmised that wide practice variation exists among burn centers with regard to insertion and maintenance of invasive catheters. Areas with particular variability that would be appropriate targets of clinical investigation are line rotation protocols, catheter site care protocols, and use of PICCs in acute burns. (J Burn Care Res 2012;33:741-746) C1 [Sheridan, Robert L.; Fagan, Shawn P.; Weber, Joan M.] Shriners Hosp Children, Boston, MA USA. [Neely, Alice N.] Shriners Hosp Children, Cincinnati, OH USA. [Castillo, Mayra A.; Chung, Kevin K.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Shankowsky, Heather A.] Univ Alberta Hosp, Firefighters Burn Treatment Unit, Edmonton, AB T6G 2B7, Canada. [Sheridan, Robert L.; Fagan, Shawn P.] Massachusetts Gen Hosp, Boston, MA 02114 USA. RP Weber, JM (reprint author), Shriners Hosp Children, 51 Blossom St, Boston, MA USA. NR 12 TC 13 Z9 14 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1559-047X J9 J BURN CARE RES JI J. Burn Care Res. PD NOV-DEC PY 2012 VL 33 IS 6 BP 741 EP 746 DI 10.1097/BCR.0b013e318254d4ab PG 6 WC Emergency Medicine; Dermatology; Surgery SC Emergency Medicine; Dermatology; Surgery GA 036ML UT WOS:000311030300020 PM 23147213 ER PT J AU Akers, KS Cota, JM Chung, KK Renz, EM Mende, K Murray, CK AF Akers, Kevin S. Cota, Jason M. Chung, Kevin K. Renz, Evan M. Mende, Katrin Murray, Clinton K. TI Serum Vancomycin Levels Resulting From Continuous or Intermittent Infusion in Critically Ill Burn Patients With or Without Continuous Renal Replacement Therapy SO JOURNAL OF BURN CARE & RESEARCH LA English DT Article ID ACUTE KIDNEY INJURY; HOSPITALIZED-PATIENTS; INFECTIONS; NEPHROTOXICITY; PHARMACODYNAMICS; PHARMACOKINETICS; DRUGS AB We evaluated vancomycin levels as recent guidelines for therapeutic monitoring of vancomycin (not available at the time these data were collected) recommend trough levels of 15 to 20 mu g/mL; however, this may be more difficult to achieve in patients with accelerated vancomycin clearance, such as burn patients or recipients of continuous venovenous hemofiltration (CVVH) therapy. We retrospectively studied 2110 serum vancomycin levels of 171 patients admitted to the burn intensive care unit for more than 4 years and who received vancomycin by continuous infusion (CI) or intermittent infusion (II), with or without simultaneous CVVH. In-hospital mortality, 14- and 28-day mortality following vancomycin therapy were not different between dosing methods, although increased mortality was observed in the subgroup of patients receiving CI vancomycin empirically for clinical sepsis with negative blood cultures. More vancomycin was delivered to patients daily by CI than II, and therapeutic drug monitoring costs were similar. After controlling for differences in vancomycin dose by case matching with propensity scores, mean vancomycin levels were 20.0 +/- 3.8 mu g/mL for CI, vs 14.8 +/- 4.4 mu g/mL for II (P < .001). CI dosing resulted in similar levels with or without CVVH, whereas in II dosing, CVVH appeared to significantly decrease vancomycin levels. Although CI dosing was associated with higher vancomycin levels in general and fewer levels of < 10 mu g/mL, significant nephrotoxicity or neutropenia was not observed. Fifty-seven patients (33.3%) developed bacteremia, and 106 Gram-positive bacteria were recovered, including 63 Staphylococcus aureus. Recurrent bacteremia while receiving vancomycin was infrequent. The 90th percentile minimum inhibitory concentration (MIC90) for vancomycin of 36 available S. aureus isolates tested by broth microdilution was 1.5 mu g/mL. CI produced more frequent therapeutic vancomycin levels and less frequent subtherapeutic levels compared to II. However, therapeutic vancomycin levels were achieved infrequently by either method of dosing. Given equivalent therapeutic drug monitoring costs and the lack of a clear clinical benefit, the role of CI dosing remains to be defined in spite of practical and theoretical advantages, particularly when administered in the setting of CVVH. (J Burn Care Res 2012;33:e254-e262) C1 [Akers, Kevin S.] Brooke Army Med Ctr, San Antonio Mil Med Ctr, Infect Dis Serv, Ft Sam Houston, TX 78234 USA. [Mende, Katrin] Uniformed Serv Univ Hlth Sci, Infect Dis Clin Res Program, Bethesda, MD 20814 USA. [Cota, Jason M.] Univ Incarnate, Dept Pharm Practice, Word Feik Sch Pharm, San Antonio, TX USA. [Chung, Kevin K.; Renz, Evan M.] USA, Burn Intens Care Unit, Inst Surg Res, Ft Sam Houston, TX USA. RP Akers, KS (reprint author), Brooke Army Med Ctr, San Antonio Mil Med Ctr, Infect Dis Serv, 3551 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. RI Valle, Ruben/A-7512-2013 NR 22 TC 11 Z9 12 U1 0 U2 6 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1559-047X EI 1559-0488 J9 J BURN CARE RES JI J. Burn Care Res. PD NOV-DEC PY 2012 VL 33 IS 6 BP E254 EP E262 DI 10.1097/BCR.0b013e31825042fa PG 9 WC Emergency Medicine; Dermatology; Surgery SC Emergency Medicine; Dermatology; Surgery GA 036ML UT WOS:000311030300001 PM 22878490 ER PT J AU Lundy, J Chung, KK Cancio, LC White, CE Ziegler, TR AF Lundy, Jonathan Chung, Kevin K. Cancio, Leopoldo C. White, Christopher E. Ziegler, Thomas R. TI Observations on Serial Plasma Citrulline Concentrations in a Patient With Intestinal Ischemia and Full-Thickness Necrosis After Severe Thermal Injury SO JOURNAL OF BURN CARE & RESEARCH LA English DT Letter ID FAILURE; MARKER C1 [Lundy, Jonathan; Chung, Kevin K.; Cancio, Leopoldo C.; White, Christopher E.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Ziegler, Thomas R.] Emory Univ, Sch Med, Atlanta, GA USA. RP Lundy, J (reprint author), USA, Inst Surg Res, 3400 Rawley Chambers Ave, Ft Sam Houston, TX 78234 USA. EM jonathan.lundy1@amedd.army.mil NR 9 TC 2 Z9 3 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1559-047X J9 J BURN CARE RES JI J. Burn Care Res. PD NOV-DEC PY 2012 VL 33 IS 6 BP E316 EP E318 DI 10.1097/BCR.0b013e31824ff9a5 PG 3 WC Emergency Medicine; Dermatology; Surgery SC Emergency Medicine; Dermatology; Surgery GA 036ML UT WOS:000311030300012 PM 22878489 ER PT J AU Weber, ML Stutzman, RD Mines, MJ Eiseman, AS Wroblewski, KJ Ryan, DS Sia, RK Bower, KS AF Weber, Marissa L. Stutzman, Richard D. Mines, Michael J. Eiseman, Andrew S. Wroblewski, Keith J. Ryan, Denise S. Sia, Rose K. Bower, Kraig S. TI Residency training in refractive surgery SO JOURNAL OF CATARACT AND REFRACTIVE SURGERY LA English DT Article ID IN-SITU KERATOMILEUSIS; PHOTOREFRACTIVE KERATECTOMY; STANDARDIZED GRAPHS; FEMTOSECOND LASER; OUTCOMES; LASIK; TERMS AB PURPOSE: To evaluate resident refractive surgery caseload and surgical outcomes in an academic medical center. SETTING: Walter Reed Army Medical Center, Washington, DC, USA. DESIGN: Comparative case study. METHODS: Keratorefractive procedures performed by residents at the Walter Reed Center for Refractive Surgery between 2002 and 2010 were reviewed. Outcomes of surgeries performed by the graduating classes of 2008 to 2010 were compared with those of cases performed by staff. The uncorrected distance visual acuity (UDVA), manifest refraction spherical equivalent, corrected distance visual acuity (CDVA), and complications were analyzed. RESULTS: Between 2002 and June 2010, residents performed 1566 procedures (1414 photorefractive keratectomy [PRK], 152 laser in situ keratomileusis), for a mean of 20.2 procedures from 2002 to 2004, 51.6 from 2005 to 2007, and 99.9 from 2008 to 2010. Outcomes analysis was performed on 333 resident eyes and 977 staff eyes treated between 2008 and June 2010. Six months postoperatively, 96.1% of resident-treated eyes and 94.6% of staff-treated eyes had a UDVA 20/20 or better (P=.312) and 61.3% and 64.3%, respectively, had a UDVA 20/15 or better (P=.324). The percentage of eyes within +/- 0.50 diopter of emmetropia at 6 months was 94.0% for residents and 91.1% for staff (P=.105). The postoperative CDVA was within 2 lines of preoperative baseline in all resident cases and 99.8% of staff cases (P=.999). CONCLUSIONS: Resident experience grew steadily over the period studied. Overall safety and efficacy of resident-performed surgery, albeit mainly PRK based, matched that of fellowship-trained refractive surgeons. C1 [Weber, Marissa L.; Stutzman, Richard D.; Mines, Michael J.; Eiseman, Andrew S.; Wroblewski, Keith J.] Reed Natl Mil Med Ctr, Bethesda, MD USA. [Ryan, Denise S.; Sia, Rose K.] USA, Warfighter Refract Surg Res Ctr Ft Belvoir, Ft Belvoir, VA USA. [Bower, Kraig S.] Johns Hopkins Univ, Wilmer Eye Inst, Baltimore, MD 21218 USA. RP Weber, ML (reprint author), 800 Washington St,Box 450, Boston, MA 02111 USA. EM marissa.weber@us.army.mil NR 20 TC 1 Z9 1 U1 1 U2 2 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0886-3350 J9 J CATARACT REFR SURG JI J. Cataract. Refract. Surg. PD NOV PY 2012 VL 38 IS 11 BP 1962 EP 1969 DI 10.1016/j.jcrs.2012.06.055 PG 8 WC Ophthalmology; Surgery SC Ophthalmology; Surgery GA 035EN UT WOS:000310926100011 PM 23079312 ER PT J AU Gifford, SM Peck, MA Reyes, AM Lundy, JB AF Gifford, Shaun M. Peck, Michael A. Reyes, Angel M. Lundy, Jonathan B. TI Methylene Blue Enteric Mapping for Intraoperative Localization in Obscure Small Bowel Hemorrhage: Report of a New Technique and Literature Review Combined Intraoperative Methylene Blue Mapping and Enterectomy SO JOURNAL OF GASTROINTESTINAL SURGERY LA English DT Review ID INTESTINAL ARTERIOVENOUS MALFORMATION; INTRA-OPERATIVE LOCALIZATION; GASTROINTESTINAL-TRACT; JEJUNAL ANGIODYSPLASIA; BLEEDING SITE; ANGIOGRAPHY; INJECTION; EMBOLIZATION; FLUORESCEIN; LESIONS AB Small bowel sources of obscure gastrointestinal bleeding present both a diagnostic and therapeutic challenge. Due to the normal external appearance of the vast majority of small bowel lesions that cause obscure gastrointestinal bleeding, multiple methods of intraoperative localization have been reported. When an arteriographic abnormality is found, the use of vital dye enteric mapping is one of the most effective localization techniques. We present a new technique combining superselective mesenteric angiography with methylene blue enteric mapping and small bowel resection performed during the same operative procedure. This technique was successfully applied in a patient with a jejunal arteriovenous malformation. Included is a review of methods of intraoperative localization with a focus on vital dye staining-guided enterectomy. C1 [Lundy, Jonathan B.] San Antonio Mil Med Ctr, Div Trauma & Acute Care Surg, Ft Sam Houston, TX 78234 USA. [Gifford, Shaun M.; Peck, Michael A.] San Antonio Mil Med Ctr, Div Vasc Surg, Ft Sam Houston, TX 78234 USA. [Reyes, Angel M.] Womack Army Med Ctr, Dept Gen Surg, Ft Bragg, NC USA. RP Lundy, JB (reprint author), San Antonio Mil Med Ctr, Div Trauma & Acute Care Surg, Ft Sam Houston, TX 78234 USA. EM jlundy1313@yahoo.com NR 45 TC 6 Z9 9 U1 0 U2 4 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1091-255X J9 J GASTROINTEST SURG JI J. Gastrointest. Surg. PD NOV PY 2012 VL 16 IS 11 BP 2177 EP 2181 DI 10.1007/s11605-012-1964-9 PG 5 WC Gastroenterology & Hepatology; Surgery SC Gastroenterology & Hepatology; Surgery GA 035QY UT WOS:000310963900020 PM 22790583 ER PT J AU Beltran, MJ Collinge, CA Patzkowski, JC Masini, BD Blease, RE Hsu, JR AF Beltran, Michael J. Collinge, Cory A. Patzkowski, Jeanne C. Masini, Brendan D. Blease, Robert E. Hsu, Joseph R. CA Skeletal Trauma Res Consortium TI The Safe Zone for External Fixator Pins in the Femur SO JOURNAL OF ORTHOPAEDIC TRAUMA LA English DT Article DE safe zone; exteranal fixation; femur; knee-spanning ID FEMORAL-SHAFT FRACTURES; PLATEAU FRACTURES; MANAGEMENT; PROTOCOL; TIBIA; KNEE AB Objective: To define the anatomic "safe zone" for placement of external fixator half pins into the anterior and lateral femur. Methods: In 20 fresh-frozen hemipelvis specimens, the femoral nerve and all branches crossing the femur were dissected out to their final muscular locations. The location where the nerves crossed the anterior femur was measured from the anterior superior iliac spine and inferior margin of the lesser trochanter. The knee joint was then opened, and the distance from the superior reflection of the suprapatellar pouch to the last branch of the femoral nerve crossing the anterior femur was measured, defining the safe zone for anterior pin placement. Results: The last branch of the femoral nerve crossed at an average distance from the anterior superior iliac spine of 174 +/- 43 mm (range, 95-248 mm) and from the lesser trochanter at a distance of 58 +/- 36 mm (range, 0-136 mm). The average distance from the proximal pole of the patella to the superior reflection of the suprapatellar pouch was 46.3 +/- 13.1 mm (range, 20-74 mm). Using the linear distance between the last crossing femoral nerve branch and the superior reflection of the pouch, the average safe zone measured 199 +/- 39.8 mm (range, 124-268 mm). The safe zone correlated with thigh length (r = 0.48, P = 0.03). All nerve branches terminated at their muscular origins without crossing lateral to a line from the anterior greater trochanter to the anterior aspect of the lateral femoral condyle. Conclusions: The safe zone for anterior external fixator half pin placement into the femur is on average 20 cm in length and can be as narrow as 12 cm. Anterior pins should begin 7.5 cm above the superior pole of the patella to avoid inadvertent knee joint penetration. Because the entire lateral femur is safely available for half pin placement, including distally, we recommend the use of alternative frame constructs with either anterolateral or lateral pins given the limitations and risks of anterior pin placement. C1 [Beltran, Michael J.; Patzkowski, Jeanne C.; Masini, Brendan D.] San Antonio Mil Med Ctr, Dept Orthopaed & Rehabil, San Antonio, TX 78234 USA. [Collinge, Cory A.] Orthopaed Specialty Associates, Ft Worth, TX USA. [Blease, Robert E.] USA, Trauma Training Ctr, Ryder Trauma Ctr, Miami, FL USA. [Hsu, Joseph R.] USA, Inst Surg Res, Dept Orthopaed, San Antonio, TX USA. RP Beltran, MJ (reprint author), San Antonio Mil Med Ctr, Dept Orthopaed & Rehabil, San Antonio, TX 78234 USA. EM michael.beltran@amedd.army.mil FU United States Army Institute of Surgical Research FX Supported by funding from the United States Army Institute of Surgical Research. NR 19 TC 7 Z9 7 U1 1 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0890-5339 J9 J ORTHOP TRAUMA JI J. Orthop. Trauma PD NOV PY 2012 VL 26 IS 11 BP 643 EP 647 DI 10.1097/BOT.0b013e31824aed95 PG 5 WC Orthopedics; Sport Sciences SC Orthopedics; Sport Sciences GA 028WR UT WOS:000310456200011 PM 22473068 ER PT J AU Beltran, MJ Burns, TC Eckel, TT Potter, BK Wenke, JC Hsu, JR AF Beltran, Michael J. Burns, Travis C. Eckel, Tobin T. Potter, Benjamin K. Wenke, Joseph C. Hsu, Joseph R. CA Skeletal Trauma Res Consortium TI Fate of Combat Nerve Injury SO JOURNAL OF ORTHOPAEDIC TRAUMA LA English DT Article; Proceedings Paper CT Scientific Meeting of the Hip-Society / Annual Meeting of the American-Academy-of-Orthopaedic-Surgeons CY FEB 15-19, 2011 CL San Diego, CA SP Hip Soc, Amer Acad Orthopaed Surg DE limb salvage; peripheral nerve injury; open tibia fracture; combat-related ID OPERATION ENDURING FREEDOM; SEVERE OPEN FRACTURES; HEALTH-SCIENCES CENTER; OPEN TIBIAL FRACTURES; IRAQI FREEDOM; SCIATIC-NERVE; PERIPHERAL-NERVES; COMPLETE LESIONS; UPPER EXTREMITY; SHOTGUN WOUNDS AB Objective: Assess a cohort of combat-related type III open tibia fractures with peripheral nerve injury to determine the injury mechanism and likelihood for recovery or improvement in nerve function. Design: Retrospective study. Setting: Three military medical centers. Patients and Participants: Out of a study cohort of 213 type III open tibia fractures, 32 fractures (in 32 patients) with a total of 43 peripheral nerve injuries (peroneal or tibial) distal to the popliteal fossa met inclusion criteria and were available for follow-up at an average of 20 months (range, 2-48 months). Main Outcome Measurements: Clinical assessment of motor and sensory nerve improvement. Results: There was a 22% incidence of peripheral nerve injury in the study cohort. At an average follow-up of 20 months (range, 2-48 months), 89% of injured motor nerves were functional, whereas the injured sensory nerves had function in 93%. Fifty percent and 27% of motor and sensory injuries demonstrated improvement, respectively (P = 0.043). With the numbers available, there was no difference in motor or sensory improvement based on mechanism of injury, fracture severity or location, soft tissue injury, or specific nerve injured. In the subset of patients with an initially impaired sensory examination, full improvement was related to fracture location (P = 0.0164). Conclusions: Type III open tibia fractures sustained in combat are associated with a 22% incidence of peripheral nerve injury, and the majority are due to multiple projectile penetrating injury. Despite the severe nature of these injuries, the vast majority of patients had a functional nerve status by an average of 2-year follow-up. Based on these findings, discussions regarding limb salvage and amputation should not be overly influenced by the patient's peripheral nerve status. C1 [Beltran, Michael J.; Burns, Travis C.] San Antonio Mil Med Ctr, Dept Orthopaed & Rehabil, Ft Sam Houston, TX 78234 USA. [Eckel, Tobin T.; Potter, Benjamin K.] Walter Reed Natl Mil Med Ctr, Dept Orthopaed & Rehabil, Bethesda, MD USA. [Wenke, Joseph C.; Hsu, Joseph R.] USA, Inst Surg Res, Dept Orthopaed & Rehabil, Ft Sam Houston, TX 78234 USA. RP Beltran, MJ (reprint author), San Antonio Mil Med Ctr, Dept Orthopaed & Rehabil, Ft Sam Houston, TX 78234 USA. EM michael.beltran@amedd.army.mil OI Potter, MD, Benjamin K./0000-0002-8771-0317 NR 36 TC 3 Z9 3 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0890-5339 J9 J ORTHOP TRAUMA JI J. Orthop. Trauma PD NOV PY 2012 VL 26 IS 11 BP E198 EP E203 DI 10.1097/BOT.0b013e31823f000e PG 6 WC Orthopedics; Sport Sciences SC Orthopedics; Sport Sciences GA 028WR UT WOS:000310456200001 PM 22437422 ER PT J AU Pulskamp, JS Polcawich, RG Rudy, RQ Bedair, SS Proie, RM Ivanov, T Smith, GL AF Pulskamp, Jeffrey S. Polcawich, Ronald G. Rudy, Ryan Q. Bedair, Sarah S. Proie, Robert M. Ivanov, Tony Smith, Gabriel L. TI Piezoelectric PZT MEMS technologies for small-scale robotics and RF applications SO MRS BULLETIN LA English DT Article ID ACTUATORS; SWITCH; RESONATORS; INSECT; STROKE AB Thin-film piezoelectric lead zirconate titanate (PZT) is one of the most efficient electromechanical coupling transducer materials currently available for microelectromechanical systems (MEMS). This article reviews piezoelectric MEMS (piezo MEMS) technologies using PZT thin films in radio frequency (RF) devices for communications and radar applications and in the emerging field of millimeter-scale robotics. The electromechanical material properties of thin-film PZT uniquely enable insect-inspired and insect-scale autonomous robots. Recent progress on large force and displacement actuators for robotic leg joints, compact and high torque ultrasonic motors, and bioinspired millimeter-scale flapping wing platforms will be presented. The use of thin-film PZT to achieve high performance and low-voltage RF MEMS switches, ultralow power consumption nanomechanical logic circuits, and high coupling and low loss resonators, filters, and transformers are also reviewed. C1 [Pulskamp, Jeffrey S.; Ivanov, Tony] USA, Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD USA. [Rudy, Ryan Q.] Univ Maryland, MEMS & Microfluid Lab, College Pk, MD 20742 USA. RP Pulskamp, JS (reprint author), USA, Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD USA. EM Jeffrey.s.pulskamp.civ@mail.mil; Ronald.g.polcawich@us.army.mil; ryanrudy@umd.edu; sarah.s.bedair.civ@mail.mil; robert.m.proie.civ@mail.mil; Gabriel.l.smith.civ@mail.mil RI Bedair, Sarah/D-9130-2013 NR 54 TC 20 Z9 20 U1 4 U2 71 PU CAMBRIDGE UNIV PRESS PI NEW YORK PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA SN 0883-7694 EI 1938-1425 J9 MRS BULL JI MRS Bull. PD NOV PY 2012 VL 37 IS 11 BP 1062 EP 1070 DI 10.1557/mrs.2012.269 PG 9 WC Materials Science, Multidisciplinary; Physics, Applied SC Materials Science; Physics GA 036SG UT WOS:000311050200018 ER PT J AU Foran, HM Adler, AB McGurk, D Bliese, PD AF Foran, Heather M. Adler, Amy B. McGurk, Dennis Bliese, Paul D. TI Soldiers' Perceptions of Resilience Training and Postdeployment Adjustment: Validation of a Measure of Resilience Training Content and Training Process SO PSYCHOLOGICAL SERVICES LA English DT Article DE resilience training; military; program evaluation; posttraumatic stress; prevention ID MENTAL-HEALTH PROBLEMS; POSTTRAUMATIC-STRESS-DISORDER; SOMATIC SYMPTOMS; IRAQ WAR; CARE; DEPRESSION; COMBAT; CONSEQUENCES; COMPONENT; VETERANS AB Group randomized trials of a resilience training program (formerly Battlemind training) demonstrated effectiveness of the program in reducing postdeployment adjustment problems among military personnel. These results are promising, but program evaluation is a dynamic, multifaceted task, and many questions remain. This article is designed to address one component of resilience training program evaluation: soldiers' perceptions of the training. Specifically, a self-report measure assessing attitudes and satisfaction in domains theorized to be important to resilience training was developed. This measure was administered to 782 soldiers who participated in a 1-hr resilience training session at 4-months postdeployment. Several mental health outcomes (e.g., alcohol problems, posttraumatic stress symptoms, physical health symptoms, unit morale) were assessed before training and 6 months later. Structural validity, internal consistency, concurrent validity, and predictive validity of the measure were examined. Analyses identified two factors reflecting attitudes toward Training Content and Training Process. The factors demonstrated good internal consistency, and both correlated with overall training satisfaction and mental health-related attitudes. In addition, both factors predicted significant positive change in a set of mental health outcomes at 6-month follow-up. Implications for postdeployment resilience training are discussed. C1 [Foran, Heather M.; Adler, Amy B.] Walter Reed Army Inst Res, Heidelberg, Germany. [McGurk, Dennis; Bliese, Paul D.] Walter Reed Army Inst Res, Silver Spring, MD USA. EM heather.m.foran.ctr@us.army.mil RI Dopko, Rae/J-7437-2015 NR 41 TC 5 Z9 5 U1 0 U2 17 PU AMER PSYCHOLOGICAL ASSOC PI WASHINGTON PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA SN 1541-1559 EI 1939-148X J9 PSYCHOL SERV JI Psychol. Serv. PD NOV PY 2012 VL 9 IS 4 SI SI BP 390 EP 403 DI 10.1037/a0028178 PG 14 WC Psychology, Clinical SC Psychology GA 036ZP UT WOS:000311071100006 PM 22545823 ER PT J AU Karasavvas, N Billings, E Rao, M Williams, C Zolla-Pazner, S Bailer, RT Koup, RA Madnote, S Arworn, D Shen, XY Tomaras, GD Currier, JR Jiang, M Magaret, C Andrews, C Gottardo, R Gilbert, P Cardozo, TJ Rerks-Ngarm, S Nitayaphan, S Pitisuttithum, P Kaewkungwal, J Paris, R Greene, K Gao, HM Gurunathan, S Tartaglia, J Sinangil, F Korber, BT Montefiori, DC Mascola, JR Robb, ML Haynes, BF Ngauy, V Michael, NL Kim, JH de Souza, MS AF Karasavvas, Nicos Billings, Erik Rao, Mangala Williams, Constance Zolla-Pazner, Susan Bailer, Robert T. Koup, Richard A. Madnote, Sirinan Arworn, Duangnapa Shen, Xiaoying Tomaras, Georgia D. Currier, Jeffrey R. Jiang, Mike Magaret, Craig Andrews, Charla Gottardo, Raphael Gilbert, Peter Cardozo, Timothy J. Rerks-Ngarm, Supachai Nitayaphan, Sorachai Pitisuttithum, Punnee Kaewkungwal, Jaranit Paris, Robert Greene, Kelli Gao, Hongmei Gurunathan, Sanjay Tartaglia, Jim Sinangil, Faruk Korber, Bette T. Montefiori, David C. Mascola, John R. Robb, Merlin L. Haynes, Barton F. Ngauy, Viseth Michael, Nelson L. Kim, Jerome H. de Souza, Mark S. CA MOPH TAVEG Collaboration TI The Thai Phase III HIV Type 1 Vaccine Trial (RV144) Regimen Induces Antibodies That Target Conserved Regions Within the V2 Loop of gp120 SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Article ID IMMUNODEFICIENCY-VIRUS TYPE-1; RECOMBINANT GLYCOPROTEIN-120 VACCINE; QUATERNARY NEUTRALIZING EPITOPE; HIV-1/SIV CHIMERIC VIRUS; ENVELOPE GLYCOPROTEIN; EFFICACY TRIAL; HETEROSEXUAL TRANSMISSION; INTEGRIN ALPHA(4)BETA(7); MONOCLONAL-ANTIBODIES; CANARYPOX VACCINE AB The Thai Phase III clinical trial (RV144) showed modest efficacy in preventing HIV-1 acquisition. Plasma collected from HIV-1-uninfected trial participants completing all injections with ALVAC-HIV (vCP1521) prime and AIDSVAX B/E boost were tested for antibody responses against HIV-1 gp120 envelope (Env). Peptide microarray analysis from six HIV-1 subtypes and group M consensus showed that vaccination induced antibody responses to the second variable (V2) loop of gp120 of multiple subtypes. We further evaluated V2 responses by ELISA and surface plasmon resonance using cyclic (Cyc) and linear V2 loop peptides. Thirty-one of 32 vaccine recipients tested (97%) had antibody responses against Cyc V2 at 2 weeks postimmunization with a reciprocal geometric mean titer (GMT) of 1100 (range: 200-3200). The frequency of detecting plasma V2 antibodies declined to 19% at 28 weeks post-last injection (GMT: 110, range: 100-200). Antibody responses targeted the mid-region of the V2 loop that contains conserved epitopes and has the amino acid sequence KQKVHALFYKLDIVPI (HXB2 Numbering sequence 169-184). Valine at position 172 was critical for antibody binding. The frequency of V3 responses at 2 weeks postimmunization was modest (18/32, 56%) with a GMT of 185 (range: 100-800). In contrast, naturally infected HIV-1 individuals had a lower frequency of antibody responses to V2 (10/20, 50%; p = 0.003) and a higher frequency of responses to V3 (19/20, 95%), with GMTs of 400 (range: 100-3200) and 3570 (range: 200-12,800), respectively. RV144 vaccination induced antibodies that targeted a region of the V2 loop that contains conserved epitopes. Early HIV-1 transmission events involve V2 loop interactions, raising the possibility that anti-V2 antibodies in RV144 may have contributed to viral inhibition. C1 [Karasavvas, Nicos; Madnote, Sirinan; Arworn, Duangnapa; Ngauy, Viseth; de Souza, Mark S.] Armed Forces Res Inst Med Sci, US Army Med Component, Dept Retrovirol, Bangkok 10400, Thailand. [Billings, Erik; Currier, Jeffrey R.; Andrews, Charla; Robb, Merlin L.] Henry M Jackson Fdn Adv Mil Med, US Mil HIV Res Program MHRP, Rockville, MD USA. [Rao, Mangala; Paris, Robert; Michael, Nelson L.; Kim, Jerome H.] Walter Reed Army Inst Res, USMHRP, Silver Spring, MD USA. [Williams, Constance; Zolla-Pazner, Susan; Cardozo, Timothy J.] NYU, Sch Med, Dept Pathol, New York, NY USA. [Williams, Constance; Zolla-Pazner, Susan; Cardozo, Timothy J.] NYU, Sch Med, Dept Pharmacol, New York, NY USA. [Zolla-Pazner, Susan] Vet Affairs Harbor Healthcare Syst, New York, NY USA. [Bailer, Robert T.; Koup, Richard A.] NIAID, Immunol Lab, Vaccine Res Ctr, NIH, Bethesda, MD 20892 USA. [Shen, Xiaoying; Tomaras, Georgia D.; Haynes, Barton F.] Duke Univ, Med Ctr, Duke Human Vaccine Inst, Durham, NC USA. [Jiang, Mike; Magaret, Craig; Gottardo, Raphael; Gilbert, Peter] Fred Hutchinson Canc Res Ctr, Vaccine & Infect Dis Div, Seattle, WA 98104 USA. [Rerks-Ngarm, Supachai] Minist Publ Hlth, Dept Dis Control, Nonthaburi, Thailand. [Nitayaphan, Sorachai] Armed Forces Res Inst Med Sci, Royal Thai Army Component, Bangkok 10400, Thailand. [Pitisuttithum, Punnee] Mahidol Univ, Fac Trop Med, Vaccine Trial Ctr, Bangkok, Thailand. [Pitisuttithum, Punnee] Mahidol Univ, Fac Trop Med, Dept Clin Trop Med, Bangkok, Thailand. [Kaewkungwal, Jaranit] Mahidol Univ, Fac Trop Med, Ctr Excellence Biomed & Publ Hlth Informat BIOPHI, Bangkok, Thailand. [Paris, Robert] Walter Reed Natl Mil Med Ctr, Bethesda, MD USA. [Greene, Kelli; Gao, Hongmei; Montefiori, David C.; Mascola, John R.] Duke Univ, Med Ctr, Dept Surg, Durham, NC 27710 USA. [Gurunathan, Sanjay; Tartaglia, Jim] Sanofi Pasteur, Swiftwater, PA USA. [Sinangil, Faruk] Global Solut Infect Dis, San Francisco, CA USA. [Korber, Bette T.] Los Alamos Natl Lab, Div Theoret, Los Alamos, NM USA. RP Karasavvas, N (reprint author), Armed Forces Res Inst Med Sci, US Army Med Component, Dept Retrovirol, 315-6 Rajvithi Rd, Bangkok 10400, Thailand. EM karasavvan@afrims.org RI Tomaras, Georgia/J-5041-2016; OI Korber, Bette/0000-0002-2026-5757 FU U.S. Army Medical Research and Materiel Command (USAMRMC) [Y1-AI-2642-12]; National Institutes of Allergy and Infectious Diseases; Henry M. Jackson Foundation for the Advancement of Military Medicine [W81XWH-07-2-0067]; U.S. Department of Defense [W81XWH-07-2-0067]; U.S. National Institute of Allergy and Infectious Diseases; Bill and Melinda Gates Foundation [OPP38744]; NIH Vaccine Research Center; NIH [HL59725, AI084119]; Department of Veterans Affairs; Bill and Melinda Gates Foundation Collaboration for AIDS Vaccine Discovery FX The authors thank SCHARP for assisting with the microarray analysis, James Swetnam for providing the biotinylated subtype B linear peptides, Kelly Soderberg for coordination of sample shipment and project management, Rob O'Connell for constructive reading of the manuscript, Robert Parks, Ryan Meyerhoff, and Krissey Lloyd for ELISA technical assistance, and Ellen Turk for performing the peptide microarray analysis. These studies were supported in part by an Interagency Agreement Y1-AI-2642-12 between U.S. Army Medical Research and Materiel Command (USAMRMC) and the National Institutes of Allergy and Infectious Diseases. In addition, this work was supported by a cooperative agreement (W81XWH-07-2-0067) between the Henry M. Jackson Foundation for the Advancement of Military Medicine and the U.S. Department of Defense. This research was funded, in part, by the U.S. National Institute of Allergy and Infectious Diseases. Peptide microarray work was funded by the Bill and Melinda Gates Foundation's Collaboration for AIDS Vaccine Discovery (OPP38744) and the NIH Vaccine Research Center. S.Z.P. and T.J.C. receive funding from NIH Grants HL59725 (S.Z.P.) and AI084119 (T.J.C.) and the Department of Veterans Affairs. Supported in part by grants from the Bill and Melinda Gates Foundation Collaboration for AIDS Vaccine Discovery to Dr. Haynes. NR 69 TC 82 Z9 82 U1 4 U2 16 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0889-2229 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD NOV PY 2012 VL 28 IS 11 BP 1444 EP 1457 DI 10.1089/aid.2012.0103 PG 14 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA 032XP UT WOS:000310754100009 PM 23035746 ER PT J AU Sobarzo, A Perelman, E Groseth, A Dolnik, O Becker, S Lutwama, JJ Dye, JM Yavelsky, V Lobel, L Marks, RS AF Sobarzo, Ariel Perelman, Eddie Groseth, Allison Dolnik, Olga Becker, Stephan Lutwama, Julius Julian Dye, John M. Yavelsky, Victoria Lobel, Leslie Marks, Robert S. TI Profiling the Native Specific Human Humoral Immune Response to Sudan Ebola Virus Strain Gulu by Chemiluminescence Enzyme-Linked Immunosorbent Assay SO CLINICAL AND VACCINE IMMUNOLOGY LA English DT Article ID VALLEY FEVER VIRUS; HEMORRHAGIC-FEVER; MONOCLONAL-ANTIBODIES; ZAIRE-EBOLAVIRUS; INFECTION; UGANDA; IGG; NUCLEOPROTEIN; GLYCOPROTEIN; APOPTOSIS AB Ebolavirus, a member of the family Filoviridae, causes high lethality in humans and nonhuman primates. Research focused on protection and therapy for Ebola virus infection has investigated the potential role of antibodies. Recent evidence suggests that antibodies can be effective in protection from lethal challenge with Ebola virus in nonhuman primates. However, despite these encouraging results, studies have not yet determined the optimal antibodies and composition of an antibody cocktail, if required, which might serve as a highly effective and efficient prophylactic. To better understand optimal antibodies and their targets, which might be important for protection from Ebola virus infection, we sought to determine the profile of viral protein-specific antibodies generated during a natural cycle of infection in humans. To this end, we characterized the profile of antibodies against individual viral proteins of Sudan Ebola virus (Gulu) in human survivors and nonsurvivors of the outbreak in Gulu, Uganda, in 2000-2001. We developed a unique chemiluminescence enzyme-linked immunosorbent assay (ELISA) for this purpose based on the full-length recombinant viral proteins NP, VP30, and VP40 and two recombinant forms of the viral glycoprotein (GP(1-294) and GP(1-649)) of Sudan Ebola virus (Gulu). Screening results revealed that the greatest immunoreactivity was directed to the viral proteins NP and GP(1-649), followed by VP40. Comparison of positive immunoreactivity between the viral proteins NP, GP(1-649), and VP40 demonstrated a high correlation of immunoreactivity between these viral proteins, which is also linked with survival. Overall, our studies of the profile of immunorecognition of antibodies against four viral proteins of Sudan Ebola virus in human survivors may facilitate development of effective monoclonal antibody cocktails in the future. C1 [Sobarzo, Ariel; Yavelsky, Victoria; Lobel, Leslie] Ben Gurion Univ Negev, Dept Virol & Dev Genet, IL-84105 Beer Sheva, Israel. [Perelman, Eddie; Marks, Robert S.] Ben Gurion Univ Negev, Dept Biotechnol Engn, IL-84105 Beer Sheva, Israel. [Groseth, Allison; Dolnik, Olga; Becker, Stephan] Univ Marburg, Inst Virol, D-3550 Marburg, Germany. [Lutwama, Julius Julian] Uganda Virus Res Inst, Dept Arbovirol Emerging & Reemerging Infect, Entebbe, Uganda. [Dye, John M.] USA, Med Res Inst Infect Dis, Div Virol, Frederick, MD 21701 USA. [Marks, Robert S.] Natl Inst Biotechnol Negev, Beer Sheva, Israel. [Marks, Robert S.] Ilse Katz Ctr Meso & Nanoscale Sci & Technol, Beer Sheva, Israel. RP Lobel, L (reprint author), Ben Gurion Univ Negev, Dept Virol & Dev Genet, IL-84105 Beer Sheva, Israel. EM llobel@bgu.ac.il RI Becker, Stephan/A-1065-2010 OI Becker, Stephan/0000-0002-2794-5659 FU National Institute of Biotechnology in the Negev, Beer-sheva, Israel; Feldman Family Foundation FX We acknowledge the support of the National Institute of Biotechnology in the Negev, Beer-sheva, Israel, and the Feldman Family Foundation. NR 43 TC 10 Z9 11 U1 1 U2 17 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 1556-6811 J9 CLIN VACCINE IMMUNOL JI Clin. Vaccine Immunol. PD NOV PY 2012 VL 19 IS 11 BP 1844 EP 1852 DI 10.1128/CVI.00363-12 PG 9 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 030IF UT WOS:000310563700019 PM 22993411 ER PT J AU Bhagwat, MJ Ramasamy, M AF Bhagwat, Mahendra J. Ramasamy, Manikandan TI Effect of tip vortex aperiodicity on measurement uncertainty SO EXPERIMENTS IN FLUIDS LA English DT Article ID HELICOPTER ROTOR; FLOW; WAKE; VORTICES AB Vortex aperiodicity introduces random uncertainty in the measured vortex center location. Unless corrected, this may lead to systematic uncertainty in the vortex properties derived from the measured velocity field. For example, the vortex core size derived from averaged or mean flow field appears larger because of aperiodicity. Several methodologies for aperiodicity correction have been developed over the past two decades to alleviate this systematic uncertainty. However, these do not always reduce the accompanying random uncertainty. The current work shows that the analysis methods used to derive the vortex properties from the measured velocity field play an important role in the resultant random uncertainty in these properties; perhaps, even more important role than the aperiodicity correction methodology itself. It is hypothesized that a class of methods called global methods, which use a large extent of measured data, yield a smaller measurement uncertainty compared to local methods. This hypothesis is verified using a newly proposed global method based on a planar least-squares fit. The general applicability of the method is demonstrated using previous particle image velocimetry measurements of rotor tip vortices. The results clearly demonstrate a reduced random uncertainty in the vortex core properties, even in the presence of secondary vortical structures. Furthermore, the results are independent of the choice of aperiodicity correction methodology. C1 [Bhagwat, Mahendra J.] USA, Aeroflightdynam Directorate AMRDEC, Ames Res Ctr, Moffett Field, CA 94035 USA. [Ramasamy, Manikandan] NASA, UARC AFDD, Ames Res Ctr, Moffett Field, CA 94035 USA. RP Bhagwat, MJ (reprint author), USA, Aeroflightdynam Directorate AMRDEC, Ames Res Ctr, M-S 215-1, Moffett Field, CA 94035 USA. EM mahendra.bhagwat@us.army.mil NR 24 TC 8 Z9 8 U1 1 U2 6 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0723-4864 J9 EXP FLUIDS JI Exp. Fluids PD NOV PY 2012 VL 53 IS 5 BP 1191 EP 1202 DI 10.1007/s00348-012-1348-7 PG 12 WC Engineering, Mechanical; Mechanics SC Engineering; Mechanics GA 031MA UT WOS:000310643600002 ER PT J AU Prokopenko, OV Bankowski, E Meitzler, T Tiberkevich, VS Slavin, AN AF Prokopenko, Oleksandr V. Bankowski, Elena Meitzler, Thomas Tiberkevich, Vasil S. Slavin, Andrei N. TI Influence of Temperature on the Performance of a Spin-Torque Microwave Detector SO IEEE TRANSACTIONS ON MAGNETICS LA English DT Article; Proceedings Paper CT International Magnetics Conference (INTERMAG) CY MAY 07-11, 2012 CL Vancouver, CANADA SP IEEE, Magnet Soc DE Microwave detector; noise properties; spin-transfer torque; temperature ID MAGNETIC TUNNEL-JUNCTIONS; PHASE-LOCKING; DRIVEN; MAGNETORESISTANCE; EXCITATIONS; DEPENDENCE; WAVES AB We analyzed the influence of temperature on the main characteristics of a passive spin-torque microwave detector (STMD): volt-watt sensitivity, signal-to-noise ratio, and minimum detectable microwave power. We reveal that these parameters do not always improve with the decrease of temperature. The developed formalism can be used for the optimization of the practical parameters of a STMD in a wide range of temperatures. C1 [Prokopenko, Oleksandr V.] Taras Shevchenko Natl Univ Kyiv, UA-01601 Kiev, Ukraine. [Bankowski, Elena; Meitzler, Thomas] USA, TARDEC, Warren, MI 48397 USA. [Tiberkevich, Vasil S.; Slavin, Andrei N.] Oakland Univ, Rochester, MI 48309 USA. RP Prokopenko, OV (reprint author), Taras Shevchenko Natl Univ Kyiv, UA-01601 Kiev, Ukraine. EM ovp@univ.kiev.ua RI Tiberkevich, Vasil/A-8697-2008; Meitzler, Thomas/D-1065-2017; OI Tiberkevich, Vasil/0000-0002-8374-2565; Meitzler, Thomas/0000-0002-0730-3958 NR 25 TC 4 Z9 4 U1 0 U2 14 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0018-9464 J9 IEEE T MAGN JI IEEE Trans. Magn. PD NOV PY 2012 VL 48 IS 11 BP 3807 EP 3810 DI 10.1109/TMAG.2012.2197853 PG 4 WC Engineering, Electrical & Electronic; Physics, Applied SC Engineering; Physics GA 025MV UT WOS:000310194400276 ER PT J AU Meyer, CD Bedair, SS Morgan, BC Arnold, DP AF Meyer, Christopher D. Bedair, Sarah S. Morgan, Brian C. Arnold, David P. TI Influence of Layer Thickness on the Performance of Stacked Thick-Film Copper Air-Core Power Inductors SO IEEE TRANSACTIONS ON MAGNETICS LA English DT Article; Proceedings Paper CT International Magnetics Conference (INTERMAG) CY MAY 07-11, 2012 CL Vancouver, CANADA SP IEEE, Magnet Soc DE Electromagnetic induction; micromachining; power integrated circuits; thick-film inductors ID DC-DC CONVERTER; CHIP; SILICON; MANAGEMENT; MHZ AB This paper presents the fabrication and characterization of air-core power inductors that leverage vertically-stacked, thick copper spiral windings to deliver high inductance densities >100 nH/mm(2) and quality factors >10 on silicon substrates. The inductors are designed for on-chip or in-package integration with high-frequency power converter circuits to enable chip-scale power management in size-constrained applications. A process for realizing the inductors through multilevel, three-dimensional molding of electroplated copper structures has been enhanced with capabilities for four independent copper layers in thicknesses of up to 30 mu m each. The impact of increasing the thickness of the stacked copper traces is specifically explored and compared to similar inductors with 10-mu m-thick stacked windings. Impedance characterization revealed a drastic decrease in the series resistance in the thicker inductors as desired but also revealed undesired eddy current and magnetic coupling effects. C1 [Meyer, Christopher D.; Bedair, Sarah S.; Morgan, Brian C.] USA, Res Lab, Bethesda, MD 20814 USA. [Meyer, Christopher D.; Arnold, David P.] Univ Florida, Dept Elect & Comp Engn, Gainesville, FL 32611 USA. RP Meyer, CD (reprint author), USA, Res Lab, Bethesda, MD 20814 USA. EM christopher.d.meyer1.civ@mail.mil RI Bedair, Sarah/D-9130-2013; Arnold, David/F-5947-2013 NR 21 TC 8 Z9 8 U1 0 U2 22 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0018-9464 EI 1941-0069 J9 IEEE T MAGN JI IEEE Trans. Magn. PD NOV PY 2012 VL 48 IS 11 BP 4436 EP 4439 DI 10.1109/TMAG.2012.2197185 PG 4 WC Engineering, Electrical & Electronic; Physics, Applied SC Engineering; Physics GA 025MV UT WOS:000310194400438 ER PT J AU Ramirez, AB Arce, GR Otero, D Paredes, JL Sadler, BM AF Ramirez, Ana B. Arce, Gonzalo R. Otero, Daniel Paredes, Jose-Luis Sadler, Brian M. TI Reconstruction of Sparse Signals From l(1) Dimensionality-Reduced Cauchy Random Projections SO IEEE TRANSACTIONS ON SIGNAL PROCESSING LA English DT Article DE Cauchy random projections; compressed sensing; dimensionality reduction; myriad filter; Restricted Isometry Property (RIP); sketching ID COORDINATE DESCENT ALGORITHMS; WEIGHTED MYRIAD FILTERS; PENALIZED REGRESSION; NOISE ENVIRONMENTS; OPTIMIZATION; COMPUTATION; RECOVERY; SEARCH AB Dimension reduction methods via linear random projections are used in numerous applications including data mining, information retrieval and compressive sensing (CS). While CS has traditionally relied on normal random projections, corresponding to l(2) distance preservation, a large body of work has emerged for applications where l(1) approximate distances may be preferred. Dimensionality reduction in l(1) often use Cauchy random projections that multiply the original data matrix B is an element of R-nxD with a Cauchy random matrix R is an element of R-kxn (k << n), resulting in a projected matrix C is an element of R-kxD. In this paper, an analogous of the Restricted Isometry Property for dimensionality reduction in l(1) is proposed using explicit tail bounds for the geometric mean of the random projections. A set of signal reconstruction algorithms from the Cauchy random projections are then developed given that the large suite of reconstruction algorithms developed in compressive sensing perform poorly due to the lack of finite second-order statistics in the projections. These algorithms are based on regularized coordinate-descent Myriad estimates using both l(0) and Lorentzian norms as sparsity inducing terms. C1 [Ramirez, Ana B.; Arce, Gonzalo R.; Otero, Daniel] Univ Delaware, Dept Elect & Comp Engn, Newark, DE 19716 USA. [Paredes, Jose-Luis] Univ Los Andes, Dept Elect Engn, Merida 5105, Venezuela. [Sadler, Brian M.] USA, Res Lab, Adelphi, MD 20783 USA. RP Ramirez, AB (reprint author), Univ Delaware, Dept Elect & Comp Engn, Newark, DE 19716 USA. EM anaberam@udel.edu; arce@udel.edu; dotero@uwaterloo.ca; paredesj@ula.ve; bsadler@arl.army.mil FU ARO [W911NF-11-1-0368]; National Science Foundation [ECCS-0725422, CIF-0915800] FX This work was supported in part by ARO Grant W911NF-11-1-0368 and in part by the National Science Foundation under the Grants ECCS-0725422 and CIF-0915800. NR 43 TC 12 Z9 12 U1 0 U2 11 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1053-587X J9 IEEE T SIGNAL PROCES JI IEEE Trans. Signal Process. PD NOV PY 2012 VL 60 IS 11 BP 5725 EP 5737 DI 10.1109/TSP.2012.2208954 PG 13 WC Engineering, Electrical & Electronic SC Engineering GA 024WB UT WOS:000310139900009 ER PT J AU Zinnert, JC AF Zinnert, Julie C. TI PLANTS AS PHYTOSENSORS: PHYSIOLOGICAL RESPONSES OF A WOODY PLANT IN RESPONSE TO RDX EXPOSURE AND POTENTIAL FOR REMOTE DETECTION SO INTERNATIONAL JOURNAL OF PLANT SCIENCES LA English DT Article DE chlorophyll fluorescence; electron transport rate; hexahydro-1,3,5-trinitro-l,3,5-triazine; hyperspectral reflectance; photosynthesis; RDX ID VEGETATION STRESS DETECTION; LEAF GAS-EXCHANGE; CHLOROPHYLL FLUORESCENCE; XANTHOPHYLL CYCLE; C-3 PLANTS; HEXAHYDRO-1,3,5-TRINITRO-1,3,5-TRIAZINE RDX; PHOTOSYNTHETIC EFFICIENCY; DEEPOXIDATION STATE; PHILLYREA-LATIFOLIA; SPECTRAL PROPERTIES AB Using plants as phytosensors could allow for large-scale detection of explosives and other anthropogenic contamination. Quantifying physiological, photosynthetic, and hyperspectral responses of plants to hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) contamination provides the basis for understanding plant signals for remote detection. Plants of the woody shrub Baccharis halimifolia (a generalist species common on many military installations) were potted in soil concentrations of RDX ranging from 100 to 1500 mg kg(-1). Physiological measurements of stomatal conductance and photosynthesis were significantly affected by RDX exposure at all treatment levels, with no overall effect on water potential. However, declines in photosynthesis and stomatal conductance were markedly different from those that occur under natural stress. Quantum use efficiency (F'(v)/F'(m)) and electron transport rate indicated that photosystem II (PSII) of RDX-treated plants was functional, with active photosynthetic reaction centers. Thus, declines in photosynthesis resulted from biochemical dysfunction in light-independent processes. Reflectance indices in the near-infrared region (R-740/R-630, R-750/R-710, and derivative indices) were most affected and may reflect the pathway on which RDX is contained within plants by being compartmentalized in the vacuole, cell wall, or lignin. These results demonstrate the potential for using plants as phytosensors to identify explosives exposure at remote distances. C1 [Zinnert, Julie C.] USA, Engineer Res & Dev Ctr, Alexandria, VA 22315 USA. [Zinnert, Julie C.] Virginia Commonwealth Univ, Dept Biol, Richmond, VA 23284 USA. RP Zinnert, JC (reprint author), USA, Engineer Res & Dev Ctr, 7701 Telegraph Rd, Alexandria, VA 22315 USA. EM jczinner@vcu.edu FU U.S. Army Corps of Engineers/Engineer Research and Development Center (ERDC) FX I thank Jean Nelson and Stephen Via for preparation of the soils and Jarrod Edwards, Jared Austin, and David Starling for assistance in data collection. This research was supported by internal basic research program funds from the U.S. Army Corps of Engineers/Engineer Research and Development Center (ERDC). NR 47 TC 6 Z9 6 U1 1 U2 24 PU UNIV CHICAGO PRESS PI CHICAGO PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA SN 1058-5893 J9 INT J PLANT SCI JI Int. J. Plant Sci. PD NOV-DEC PY 2012 VL 173 IS 9 BP 1005 EP 1014 DI 10.1086/667608 PG 10 WC Plant Sciences SC Plant Sciences GA 030MB UT WOS:000310573700005 ER PT J AU Sperry, JH Barron, DG Weatherhead, PJ AF Sperry, Jinelle H. Barron, Douglas G. Weatherhead, Patrick J. TI Snake behavior and seasonal variation in nest survival of northern cardinals Cardinalis cardinalis SO JOURNAL OF AVIAN BIOLOGY LA English DT Article ID BLACK RAT SNAKES; ELAPHE-OBSOLETA; PREDATION; HABITAT; BIRDS; RATSNAKES; PATTERNS; SELECTION; SUCCESS; VIDEO AB Seasonal variation in nest success is well documented for many bird species. Predator behavior has been suggested as a mechanism behind these seasonal patterns, but this hypothesis has received little attention. Here we test the hypothesis that predator behavior produces seasonal patterns of nest success by relating nest success of northern cardinals Cardinalis cardinalis to the activity of Texas rat snakes Elaphe obsoleta. Cardinal nest survival varied over the season and was lower when rat snakes were more active. The probability that a nest survived was associated both with when cardinals nested and with nest height, indicating that both temporal and habitat factors affected predation risk. The increased success of higher nests could be associated with some aspect of rat snakes climbing ability. In combination with results for two other species studied previously at the same location, our results for cardinals suggest that the specific seasonal pattern of nest success expected for a given bird species will depend on how its nesting season coincides with predator activity. Determining the generality of seasonal variation in predator behavior as a mechanism for producing seasonal patterns of avian nest success will require additional studies that investigate birds and their nest predators simultaneously. C1 [Sperry, Jinelle H.; Barron, Douglas G.; Weatherhead, Patrick J.] Univ Illinois, Program Ecol Evolut & Conservat Biol, Champaign, IL 61820 USA. RP Sperry, JH (reprint author), Engn Res & Dev Ctr, POB 9005, Champaign, IL 61826 USA. EM jinelle.sperry@usace.army.mil FU U.S. Army through an Natural Resources Management Branch at Fort Hood; U.S. Army ERDC; Univ. of Illinois Urbana-Champaign; Army Corps of Engineers, Engineer Research and Development Center FX Funding for this project was provided by the U.S. Army through an agreement between the Natural Resources Management Branch at Fort Hood, U.S. Army ERDC, and Univ. of Illinois Urbana-Champaign. Additional support was provided by Army Corps of Engineers, Engineer Research and Development Center. We thank J. Cornelius and T. Hayden for help in arranging funding as well as C. Pekins, G. Eckrich and The Nature Conservancy for logistical support. We thank numerous field biologists for field assistance. All work was approved by the Institutional Animal Care and Use Committee of the Univ. of Illinois Urbana-Champaign. NR 37 TC 9 Z9 9 U1 3 U2 34 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0908-8857 J9 J AVIAN BIOL JI J. Avian Biol. PD NOV PY 2012 VL 43 IS 6 BP 496 EP 502 DI 10.1111/j.1600-048X.2012.05632.x PG 7 WC Ornithology SC Zoology GA 033MP UT WOS:000310801400004 ER PT J AU Davis, ED Wagner, A McEntee, M Kaur, M Troya, D Morris, JR AF Davis, Erin Durke Wagner, Alec McEntee, Monica Kaur, Manpreet Troya, Diego Morris, John R. TI Reaction Probability and Infrared Detection of the Primary Ozonide in Collisions of O-3 with Surface-Bound C-60 SO JOURNAL OF PHYSICAL CHEMISTRY LETTERS LA English DT Article ID SELF-ASSEMBLED MONOLAYERS; GAS-PHASE OZONE; C-70 FULLERENES; REACTION-KINETICS; THIN-FILMS; SOLID C-60; OZONATION; DECOMPOSITION; OZONOLYSIS; OXIDATION AB The kinetics and mechanism of reactions between gas-phase ozone and surface-bound C-60 have been investigated by monitoring changes to reflection-absorption infrared spectra within a well-characterized film of C-60 during exposure to a controlled flux of pure ozone. These ultrahigh vacuum studies provide direct infrared spectroscopic evidence for the formation and decomposition of a primary ozonide of C-60. The spectral assignments of this highly unstable intermediate have been verified using electronic structure calculations. Theory and experiment revealed that C-60 oxidized nearly exclusively via addition of ozone across the double bond that links two six-carbon-containing rings of the molecule. Following spectral characterization, the initial probability for ozone to react with the surface was found to be 5.8 +/- 0.2 x 10(-4). Once formed, the ozonide quickly thermally decomposed to a variety of carbonyl-containing products. C1 [Wagner, Alec; Kaur, Manpreet; Troya, Diego; Morris, John R.] Virginia Tech, Dept Chem, Blacksburg, VA 24061 USA. [Davis, Erin Durke] USA, Edgewood Chem Biol Ctr, Edgewood, MD 21010 USA. [McEntee, Monica] Univ Virginia, Dept Chem, Charlottesville, VA 22904 USA. RP Morris, JR (reprint author), Virginia Tech, Dept Chem, Blacksburg, VA 24061 USA. EM erin.d.davis9.ctr@mail.mil; atw136@vt.edu; mlm4gf@virginia.edu; khmanp8@vt.edu; troya@vt.edu; jrmorris@vt.edu FU NSF [CHE-0948293] FX The authors would like to thank the NSF for supporting this work (CHE-0948293). We are also grateful to Professor Linsey Marr and Andrea Tiwari for many helpful discussions. NR 57 TC 9 Z9 9 U1 0 U2 38 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1948-7185 J9 J PHYS CHEM LETT JI J. Phys. Chem. Lett. PD NOV 1 PY 2012 VL 3 IS 21 BP 3193 EP 3198 DI 10.1021/jz3012518 PG 6 WC Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Physics, Atomic, Molecular & Chemical SC Chemistry; Science & Technology - Other Topics; Materials Science; Physics GA 032JH UT WOS:000310713000020 PM 26296028 ER PT J AU Pan, YL Huang, H Chang, RK AF Pan, Yong-Le Huang, Hermes Chang, Richard K. TI Clustered and integrated fluorescence spectra from single atmospheric aerosol particles excited by a 263-and 351-nm laser at New Haven, CT, and Adelphi, MD SO JOURNAL OF QUANTITATIVE SPECTROSCOPY & RADIATIVE TRANSFER LA English DT Article DE Fluorescence spectra; Atmospheric aerosol particles; Hierarchical cluster analysis; Time integrated spectral profiles; 263-and 351-nm lasers; Bioaerosol ID REAL-TIME MEASUREMENT; BIOLOGICAL AEROSOL; INTRINSIC FLUORESCENCE; UV FLUORESCENCE; ORGANIC-CARBON; CLASSIFICATION; SPECTROSCOPY; EXCITATION; SCATTERING; SPECTROMETER AB Fluorescence spectra from individual micron-sized atmospheric aerosol particles were measured by a Dual-wavelength-excitation Particle Fluorescence Spectrometer (DPFS). Particles were drawn into our laboratory at Adelphi, MD, an urban site in the Washington, DC, metroplex and within the Yale University campus at New Haven, CT. Two fluorescence spectra were obtained for every individual particle as it was moving through the DPFS system and excited sequentially by single laser pulses at 263 and 351 nm. There were around ten to a few hundred particles detected per second and up to a few million per day within the 1-10 mu m particle size range. The majority of the particles have weak fluorescence, but 10-50% of the particles have fluorescence signals above the noise level at both sites at different time period. For the first time, these Ultra Violet laser-induced-fluorescence (UV-LIF) spectra from individual particles were integrated every 10 min, which forms a group of about a few thousand to a few tens of thousand particles, to provide the averaged background atmospheric fluorescence spectral profiles which may be helpful in the development of bioaerosol detection systems, particularly those systems based on integrated fluorescence from a group of aerosol particles, such as Light Detection And Rangeing (LIDAR) remotor biosensor and the point sensor based on collected particles on substrate. These integrated spectral profiles had small variations from time to time and were distinguishable from that of the bacterial simulant B. subtilis. Also for the first time, the individual spectra excited by a 351 nm laser were grouped using unstructured hierarchical cluster analysis, with parameters chosen so that spectra clustered into 8 main categories. They showed less spectral variations than that excited by a 263-nm laser. Over 98% of the spectra were able to be grouped into 8 clusters, and over 90% of the fluorescent particles were in clusters 3-5 with a fluorescence emission peak around 420-470 nm; these were mostly from biological and organic carbon-containing compounds. Integrated fluorescence spectral profiles and averaged spectra for each cluster show high similarity between New Haven, CT and Adelphi, MD. Published by Elsevier Ltd. C1 [Pan, Yong-Le] USA, Res Lab, Adelphi, MD 20783 USA. [Huang, Hermes] Real Time Analyzers Inc, Middletown, CT 06457 USA. [Chang, Richard K.] Yale Univ, Dept Appl Phys, New Haven, CT 06520 USA. RP Pan, YL (reprint author), USA, Res Lab, Adelphi, MD 20783 USA. EM yongle.pan.civ@mail.mil FU Defense Threat Reduction Agency (DTRA); US Army Research Laboratory mission funds FX This research was supported by the Defense Threat Reduction Agency (DTRA) and the US Army Research Laboratory mission funds. We are thankful for helpful discussions with Drs. Steve Hill and Ron Pinnick. NR 36 TC 10 Z9 11 U1 1 U2 29 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0022-4073 J9 J QUANT SPECTROSC RA JI J. Quant. Spectrosc. Radiat. Transf. PD NOV PY 2012 VL 113 IS 17 BP 2213 EP 2221 DI 10.1016/j.jqsrt.2012.07.028 PG 9 WC Optics; Spectroscopy SC Optics; Spectroscopy GA 031RP UT WOS:000310660300007 ER PT J AU Gupta, A Kim, BC Edwards, E Brantley, C Ruffin, P AF Gupta, Anurag Kim, Bruce C. Edwards, Eugene Brantley, Christina Ruffin, Paul TI Covalent functionalization of zinc oxide nanowires for high sensitivity p-nitrophenol detection in biological systems SO MATERIALS SCIENCE AND ENGINEERING B-ADVANCED FUNCTIONAL SOLID-STATE MATERIALS LA English DT Article DE Zinc oxide nanowire; Surface functionalization; 1-Pyrenebutyric acid; Fluorescent sensing ID THIN-FILMS; ZNO; NANOPARTICLES; GROWTH; ORGANOPHOSPHATES; TRINITROPHENOL; 4-NITROPHENOL; MECHANISM; SENSOR AB High-quality zinc oxide (ZnO) nanowires were synthesized using the atmospheric chemical vapor deposition technique and were appropriately characterized. Subsequently, the nanowire surface was covalently grafted with 1-pyrenebutyric acid (PBA) fluorophore, and surface-sensitive X-ray photoelectron spectroscopy and Fourier transform infrared-attenuated total reflectance spectroscopy were utilized to confirm the functionalization of 1-pyrenebutyric acid on the nanowire surface. Additionally. photoluminescence (PL) measurements were used to evaluate the Optical behavior of pristine nanowires. Through fluorescence quenching of 1-pyrenebutyric acid by p-nitrophenol. a detection limit of 28 ppb was estimated. Based on these findings, ZnO nanowires functionalized with 1-pyrenebutyric acid are envisaged as extremely sensitive platforms for the ultra-trace detection of p-nitrophenol in biological systems. (C) 2012 Elsevier B.V. All rights reserved. C1 [Gupta, Anurag; Kim, Bruce C.] Univ Alabama, Tuscaloosa, AL 35487 USA. [Edwards, Eugene; Brantley, Christina; Ruffin, Paul] USA, RDECOM AMRDEC, Redstone Arsenal, AL 35898 USA. RP Gupta, A (reprint author), Univ Alabama, 101 Houser Hall, Tuscaloosa, AL 35487 USA. EM agupta16@crimson.ua.edu FU U.S. Army [W31P4Q-09-D-0028] FX This work was partially funded by the U.S. Army Contract No. W31P4Q-09-D-0028, AMRDEC in Huntsville, AL NR 31 TC 5 Z9 5 U1 3 U2 32 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0921-5107 J9 MATER SCI ENG B-ADV JI Mater. Sci. Eng. B-Adv. Funct. Solid-State Mater. PD NOV 1 PY 2012 VL 177 IS 18 BP 1583 EP 1588 DI 10.1016/j.mseb.2012.08.002 PG 6 WC Materials Science, Multidisciplinary; Physics, Condensed Matter SC Materials Science; Physics GA 033BL UT WOS:000310767500002 ER PT J AU O'Connor, FG Bergeron, MF Cantrell, J Connes, P Harmon, KG Ivy, E Kark, J Klossner, D Lisman, P Meyers, BK O'Brien, K Ohene-Frempong, K Thompson, AA Whitehead, J Deuster, PA AF O'Connor, Francis G. Bergeron, Michael F. Cantrell, Joyce Connes, Philippe Harmon, Kimberly G. Ivy, Edward Kark, John Klossner, Dave Lisman, Peter Meyers, Bryce K. O'Brien, Karen Ohene-Frempong, Kwaku Thompson, Alexis A. Whitehead, James Deuster, Patricia A. TI ACSM and CHAMP Summit on Sickle Cell Trait: Mitigating Risks for Warfighters and Athletes SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Article DE ATHLETIC HEALTH; EXERCISE COLLAPSE; HEMOGLOBINOPATHIES; RISK MANAGEMENT ID SUDDEN-DEATH; ALPHA-THALASSEMIA; BLOOD RHEOLOGY; ADHESION MOLECULES; ARMED-FORCES; EXERTIONAL RHABDOMYOLYSIS; MALIGNANT HYPERTHERMIA; EXERCISE PERFORMANCE; ENDURANCE EXERCISE; STRENUOUS EXERCISE AB O'CONNOR, F. G., M. F. BERGERON, J. CANTRELL, P. CONNES, K. G. HARMON, E. IVY, J. KARK, D. KLOSSNER, P. LISMAN, B. K. MEYERS, K. 0 BRIEN, K. OHENE-FREMPONG, A. A. THOMPSON, J. WHITEHEAD, AND P. A. DEUSTER. ACSM and CHAMP Summit on Sickle Cell Trait: Mitigating Risks for Warfighters and Athletes. Med. Set. Sports Ererc., Vol. 44, No. 11, pp. 2045-2056, 2012. Introduction: An estimated 300 million people worldwide have sickle cell trait (SCT). Although largely benign, SCT has been associated with exertional rhabdomyolysis and exercise-related sudden death in warfighters/athletes (WA). The National Collegiate Athletic Association's policy to confirm a student athlete's SCT status during their preparticipation medical examination prompted reaction from some organizations regarding the rationale and ethical justification of the policy. Methods: On September 26 and 27, 2011, a summit, composed of military and civilian experts in sports medicine and SCT, was convened at the Uniformed Services University in Bethesda, MD. The expert panel was charged with two objectives: 1) to provide specific recommendations to further mitigate the apparent risk with strenuous exercise in WA with SCT and 2) to develop clinical guidelines to identify, treat, and return to duty/play WA suspected to have incurred nonfatal sickle cell collapse. Results: New terminology is introduced, areas of current controversy are explored, consensus recommendations for mitigating risk and managing the WA with SCT are reviewed, and important areas for future research are identified. Conclusion: Further research is needed before conclusions can be drawn regarding the etiology of the increased death rate observed in WA with SCT, and the possibility exists that SCT is a surrogate for as yet another contributing factor for the unexplained deaths. C1 [O'Connor, Francis G.; Lisman, Peter; Deuster, Patricia A.] Uniformed Serv Univ Hlth Sci, Dept Mil & Emergency Med, Bethesda, MD 20814 USA. [Bergeron, Michael F.] Sanford USD Med Ctr, Natl Inst Athlet Hlth & Performance, Sioux Falls, SD USA. [Cantrell, Joyce] Uniformed Serv Univ Hlth Sci, Dept Prevent Med & Biometr, Bethesda, MD 20814 USA. [Connes, Philippe] Univ Antilles Guyane, INSERM, UMR 665, Pointe A Pitre, Guadeloupe. [Harmon, Kimberly G.] Univ Washington, Dept Family Med, Seattle, WA 98195 USA. [Harmon, Kimberly G.] Univ Washington, Dept Orthopaed & Sports Med, Seattle, WA 98195 USA. [Ivy, Edward] NHLBI, Bethesda, MD 20892 USA. [Kark, John] Howard Univ Hosp, Div Hematol Oncol, Washington, DC USA. [Klossner, Dave] Natl Collegiate Athlet Assoc, Indianapolis, IN USA. [Meyers, Bryce K.] Walter Reed Army Inst Res, Div Prevent Med, Silver Spring, MD USA. [O'Brien, Karen] Madigan Army Med Ctr, Tacoma, WA 98431 USA. [Ohene-Frempong, Kwaku] Childrens Hosp Philadelphia, Ctr Comprehens Sickle Cell, Philadelphia, PA 19104 USA. [Thompson, Alexis A.] Northwestern Univ, Feinberg Sch Med, Chicago, IL 60611 USA. [Whitehead, James] Amer Coll Sports Med, Indianapolis, IN USA. RP O'Connor, FG (reprint author), Uniformed Serv Univ Hlth Sci, Dept Mil & Emergency Med, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA. EM francis.oconnor@usuhs.edu RI Deuster, Patricia/G-3838-2015; OI Deuster, Patricia/0000-0002-7895-0888; Philippe, Connes/0000-0001-8449-7998 NR 100 TC 21 Z9 21 U1 2 U2 12 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD NOV PY 2012 VL 44 IS 11 BP 2045 EP 2056 DI 10.1249/MSS.0b013e31826851c2 PG 12 WC Sport Sciences SC Sport Sciences GA 024QD UT WOS:000310122800001 PM 22811029 ER PT J AU Torres, IP Torres, LN Spiess, BD AF Torres Filho, Ivo P. Torres, Luciana N. Spiess, Bruce D. TI In vivo microvascular mosaics show air embolism reduction after perfluorocarbon emulsion treatment SO MICROVASCULAR RESEARCH LA English DT Article ID GAS EMBOLISM; BUBBLE ADHESION; SURFACTANT; DAMAGE; MICROCIRCULATION; HEMODILUTION; REPERFUSION; ABSORPTION; DYNAMICS; TISSUE AB Massive arteriolar gas embolism (AGE) has never been evaluated in vivo using intravital microscopy and previous perfluorocarbon (PFC) emulsions were only effective in AGE when administered before AGE. We implemented a new system for quantitative studies of massive AGE using brightfield microscopy and tested a treatment with a third-generation PFC emulsion after massive AGE. We studied bubble dynamics in cremaster muscles from anesthetized rats after AGE was induced by direct air injection into the femoral artery ipsilateral to the studied muscle. Using a motorized microscope stage and a color camera, in vivo microvascular mosaics were produced on-line from over 2000 digital images to evaluate multiple networks in order to investigate the distribution, lodging, breaking, reduction and moving of 105 air bubbles in microvessels. Thirty minutes after PFC treatment, there was a reduction of 80% in bubble volume while untreated and saline-treated rats showed significantly smaller decreases of 33% and 40%, respectively (p<0.05). Air bubbles also dissolved into a larger number of smaller bubbles after PFC treatment. The proposed methodology may prove useful for rapid in vivo data acquisition from large networks. Since large air bubbles broke-up, decreased in length and volume, and moved toward smaller microvessels, the study provides quantitative data to support a mechanism by which PFC may improve tissue blood flow following massive AGE. The findings suggest that this new generation of PFC emulsions administered after severe AGE may reach compromised microvascular networks and provide help to alleviate microvascular obstruction by increasing air bubble reabsorption. (C) 2012 Elsevier Inc. All rights reserved. C1 [Torres, Luciana N.; Spiess, Bruce D.] Virginia Commonwealth Univ, Dept Anesthesiol, Virginia Commonwealth Univ Reanimat Engn Shock Ct, Richmond, VA 23298 USA. [Torres Filho, Ivo P.; Spiess, Bruce D.] Virginia Commonwealth Univ, Dept Emergency Med, Virginia Commonwealth Univ Reanimat Engn Shock Ct, Richmond, VA 23298 USA. [Torres Filho, Ivo P.] Virginia Commonwealth Univ, Dept Internal Med, Virginia Commonwealth Univ Reanimat Engn Shock Ct, Richmond, VA 23298 USA. RP Torres, IP (reprint author), USA, Inst Surg Res, 3698 Chambers Pass,Bldg 3611,BHT 2,Room 282-2, Ft Sam Houston, TX 78234 USA. EM ivoptf@msn.com FU Office of Naval Research (ONR) [N000140810461]; ONR [N000140810474] FX The authors would like to thank Brian Berger for the help during various phases of the study. Ivo Torres Filho was also supported by the Universidade do Estado do Rio de Janeiro. Luciana Torres was a postdoctoral fellow awarded by the Office of Naval Research (ONR; # N000140810461). This work was supported in part by a grant from the ONR: N000140810474. NR 25 TC 2 Z9 2 U1 0 U2 2 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0026-2862 J9 MICROVASC RES JI Microvasc. Res. PD NOV PY 2012 VL 84 IS 3 BP 390 EP 394 DI 10.1016/j.mvr.2012.08.002 PG 5 WC Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 034GZ UT WOS:000310862200024 PM 23010091 ER PT J AU Kenefick, RW Cheuvront, SN AF Kenefick, Robert W. Cheuvront, Samuel N. TI Hydration for recreational sport and physical activity SO NUTRITION REVIEWS LA English DT Review DE fluid needs; leisure activity; predicted sweat loss ID EXERCISE-INDUCED DEHYDRATION; HEAT-STRESS; PERFORMANCE; FLUID; HYPOHYDRATION; HYPERTHERMIA; TEMPERATURE; ELECTROLYTE; INGESTION; ENDURANCE AB This review presents recommendations for fluid needs and hydration assessment for recreational activity. Fluid needs are based on sweat losses, dependent on intensity and duration of the activity, and will vary among individuals. Prolonged aerobic activity is adversely influenced by dehydration, and heat exposure will magnify this effect. Fluid needs predicted for running 542 km at recreational paces show that fluid losses are <2% body mass; thus, aggressive fluid replacement may not be necessary. Competitive paces result in greater fluid losses and greater fluid needs. Fluid needs for recreational activity may be low; however, carbohydrate consumption (sport drinks, gels, bars) can benefit high-intensity (<= 1 h) and less-intense, long-duration activity (>= 1 h). Spot measures of urine color or urine-specific gravity to assess hydration status have limitations. First morning urine concentration and body mass with gross thirst perception can be simple ways to assess hydration status. (C) 2012 International Life Sciences Institute C1 [Kenefick, Robert W.] USA, Environm Med Res Inst, Thermal & Mt Med Div, Natick, MA 01760 USA. RP Kenefick, RW (reprint author), USA, Environm Med Res Inst, Thermal & Mt Med Div, Kansas St, Natick, MA 01760 USA. EM Robert.Kenefick@us.army.mil NR 54 TC 18 Z9 18 U1 1 U2 46 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0029-6643 J9 NUTR REV JI Nutr. Rev. PD NOV PY 2012 VL 70 SU 2 SI SI BP S137 EP S142 DI 10.1111/j.1753-4887.2012.00523.x PG 6 WC Nutrition & Dietetics SC Nutrition & Dietetics GA 030WV UT WOS:000310601700008 PM 23121349 ER PT J AU Ter-Gabrielyan, N Fromzel, V Dubinskii, M AF Ter-Gabrielyan, N. Fromzel, V. Dubinskii, M. TI Linear thermal expansion and thermo-optic coefficients of YVO4 crystals the 80-320 K temperature range SO OPTICAL MATERIALS EXPRESS LA English DT Article ID LASER; CONDUCTIVITY; ND AB We present the measurement results for coefficients of linear thermal expansion (CTE) and thermo-optic coefficients of uniaxial yttrium orthovanadate YVO4 crystals in the temperature range 80 - 320 K. The CTE data were obtained for the directions parallel (alpha(parallel to)) and perpendicular (alpha(perpendicular to)) to the optical c-axis of YVO4. The corresponding polynomial expressions for the observed temperature dependencies were derived. At 80 K the CTE values alpha(perpendicular to) similar to 0.11.10(-6)K(-1) and alpha(parallel to) similar to 2.43.10(-6)K(-), are approximately 5.3% and 28% of those at room temperature, respectively. Thermo-optic coefficients corresponding to ordinary and extra-ordinary beams were measured for two wavelengths, 633 and 1570 nm. To the best of our knowledge, the CTE and dn/dT data for this important laser host in the temperature range 80 - 320 K are reported for the first time. (C) 2012 Optical Society of America C1 [Ter-Gabrielyan, N.; Fromzel, V.; Dubinskii, M.] USA, Res Lab, Adelphi, MD 20783 USA. RP Ter-Gabrielyan, N (reprint author), USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM nikolay.e.ter-gabrielyan.civ@mail.mil NR 10 TC 6 Z9 6 U1 0 U2 13 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 2159-3930 J9 OPT MATER EXPRESS JI Opt. Mater. Express PD NOV 1 PY 2012 VL 2 IS 11 BP 1624 EP 1631 PG 8 WC Materials Science, Multidisciplinary; Optics SC Materials Science; Optics GA 031NB UT WOS:000310647500018 ER PT J AU Wengraitis, S Reed, NG AF Wengraitis, Stephen Reed, Nicholas G. TI Ultraviolet Spectral Reflectance of Ceiling Tiles, and Implications for the Safe Use of Upper-Room Ultraviolet Germicidal Irradiation SO PHOTOCHEMISTRY AND PHOTOBIOLOGY LA English DT Article ID AIR DISINFECTION; HISTORY AB Ultraviolet germicidal irradiation can be used to prevent airborne transmission of infectious diseases. A common application is to irradiate upper-room areas, by passing air from the lower room into the irradiated zone. Well-designed systems do not expose people directly; however, some UV radiation may be reflected off ceiling tiles and wall paints into the lower room. Lower room exposure should be limited to the American Conference of Governmental Industrial Hygienists threshold limit value of 6 mJ center dot cm(-2) of 254 nm radiation per day. To limit the lower room exposure, the reflectance of upper-room surfaces must not be high. The reflective properties of wall paints have been studied, but less is known about the UV reflectance of ceiling tiles. Using a double monochromator spectroradiometer and an integrating sphere reflectance attachment, the UV spectral reflectance of 37 ceiling tiles was measured from 200 to 400 nm. The reflectances varied from 0.020 to 0.822 in this range, and from 0.035 to 0.459 at 254 nm, the main wavelength emitted by upper room low-pressure mercury germicidal lamps. These data were then used to estimate an 8 h exposure based on several simplified workplace scenarios. The implications for workplace safety are then discussed. C1 [Wengraitis, Stephen] USA, Publ Hlth Command, MCHB IP OLO, Aberdeen Proving Ground, MD USA. [Reed, Nicholas G.] ORAU ORISE Maryland, Belcamp, MD USA. RP Wengraitis, S (reprint author), USA, Publ Hlth Command, MCHB IP OLO, Aberdeen Proving Ground, MD USA. EM steve.wengraitis@mail.us.army.mil FU U.S. Department of Energy; US-APHC FX This project was supported in part by an appointment to the Internship/Research Participation Program for the US Army Public Health Command (USAPHC) administered by the Oak Ridge Institute for Science and Education through an agreement between the U.S. Department of Energy and the US-APHC. The views expressed in this article are the views of the authors and do not reflect the official policy or position of the Department of the Army, the Department of Defense, or the U.S. government. Use of trademarked name does not imply endorsement by the U.S. Army, but is intended only to assist in identification of a specific product. NR 32 TC 3 Z9 3 U1 1 U2 7 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0031-8655 J9 PHOTOCHEM PHOTOBIOL JI Photochem. Photobiol. PD NOV-DEC PY 2012 VL 88 IS 6 BP 1480 EP 1488 DI 10.1111/j.1751-1097.2012.01193.x PG 9 WC Biochemistry & Molecular Biology; Biophysics SC Biochemistry & Molecular Biology; Biophysics GA 030IB UT WOS:000310563300020 PM 22731691 ER PT J AU Bhandari, RK Oda, RP Youso, SL Petrikovics, I Bebarta, VS Rockwood, GA Logue, BA AF Bhandari, Raj K. Oda, Robert P. Youso, Stephanie L. Petrikovics, Ilona Bebarta, Vikhyat S. Rockwood, Gary A. Logue, Brian A. TI Simultaneous determination of cyanide and thiocyanate in plasma by chemical ionization gas chromatography mass-spectrometry (CI-GC-MS) SO ANALYTICAL AND BIOANALYTICAL CHEMISTRY LA English DT Article DE Cyanide; Thiocyanate; Method development; Chemical-ionization gas-chromatographymass-spectrometry ID SOLID-PHASE MICROEXTRACTION; NITROGEN PHOSPHORUS DETECTION; ELECTRON-CAPTURE DETECTION; BLOOD CYANIDE; WHOLE-BLOOD; PSEUDOMONAS-AERUGINOSA; BIOLOGICAL-FLUIDS; FIRE VICTIMS; DERIVATIZATION; CONVERSION AB An analytical method utilizing chemical ionization gas chromatography-mass spectrometry was developed for the simultaneous determination of cyanide and thiocyanate in plasma. Sample preparation for this analysis required essentially one-step by combining the reaction of cyanide and thiocyanate with pentafluorobenzyl bromide and simultaneous extraction of the product into ethyl acetate facilitated by a phase-transfer catalyst, tetrabutylammonium sulfate. The limits of detection for cyanide and thiocyanate were 1 mu M and 50 nM, respectively. The linear dynamic range was from 10 mu M to 20 mM for cyanide and from 500 nM to 200 mu M for thiocyanate with correlation coefficients higher than 0.999 for both cyanide and thiocyanate. The precision, as measured by %RSD, was below 9 %, and the accuracy was within 15 % of the nominal concentration for all quality control standards analyzed. The gross recoveries of cyanide and thiocyanate from plasma were over 90 %. Using this method, the toxicokinetic behavior of cyanide and thiocyanate in swine plasma was assessed following cyanide exposure. C1 [Bhandari, Raj K.; Oda, Robert P.; Youso, Stephanie L.; Logue, Brian A.] S Dakota State Univ, Dept Chem & Biochem, Brookings, SD 57007 USA. [Petrikovics, Ilona] Sam Houston State Univ, Dept Chem, Huntsville, TX 77341 USA. [Bebarta, Vikhyat S.] USAF, San Antonio Mil Med Ctr, San Antonio, TX 78229 USA. [Rockwood, Gary A.] USA, Med Res Inst Chem Def, Analyt Toxicol Div, Aberdeen Proving Ground, MD 21010 USA. RP Logue, BA (reprint author), S Dakota State Univ, Dept Chem & Biochem, Avera Hlth & Sci Ctr 131,Box 2202, Brookings, SD 57007 USA. EM Vikhyat.bebarta@us.af.mil; brian.logue@sdstate.edu RI bebarta, vikhyat/K-3476-2015 FU CounterACT Program; National Institutes of Health Office of the Director; National Institute of Allergy and Infectious Diseases [Y1-OD-0690-01/A-120-B.P2010-01, Y1-OD-1561-01/A120-B.P2011-01]; USAMRICD under US Army Research Office of Scientific Services Program [W911NF-11-D-0001]; Battelle [TCN 11077]; Oak Ridge Institute for Science and Education (ORISE) FX The research was supported by the CounterACT Program, National Institutes of Health Office of the Director, and the National Institute of Allergy and Infectious Diseases, Inter Agency Agreement Number Y1-OD-0690-01/A-120-B.P2010-01, Y1-OD-1561-01/A120-B.P2011-01, and the USAMRICD under the auspices of the US Army Research Office of Scientific Services Program Contract No. W911NF-11-D-0001 administered by Battelle (delivery order 0079, contract no TCN 11077). We gratefully acknowledge the funding from the Oak Ridge Institute for Science and Education (ORISE). The authors would also like to acknowledge Dr. George Perry, Associate Professor, Animal and Range Science of South Dakota State University, for making arrangements to provide swine plasma. The authors are thankful to Susan M. Boudreau, RN, BSN, Maria G. Castaneda, MS, Toni E. Vargas, PA-C, MHS, and Patricia Dixon, MHS, from the Clinical Research Division, Wilford Medical Center, Lackland A F B, TX, for providing cyanide exposed swine plasma samples for these studies. The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the Department of the Army, the National Institutes of Health, or the Department of Defense. NR 48 TC 19 Z9 20 U1 4 U2 41 PU SPRINGER HEIDELBERG PI HEIDELBERG PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY SN 1618-2642 J9 ANAL BIOANAL CHEM JI Anal. Bioanal. Chem. PD NOV PY 2012 VL 404 IS 8 BP 2287 EP 2294 DI 10.1007/s00216-012-6360-5 PG 8 WC Biochemical Research Methods; Chemistry, Analytical SC Biochemistry & Molecular Biology; Chemistry GA 024BY UT WOS:000310083900021 PM 22941221 ER PT J AU Armistead-Jehle, P Gervais, RO Green, P AF Armistead-Jehle, Patrick Gervais, Roger O. Green, Paul TI Memory Complaints Inventory and Symptom Validity Test Performance in a Clinical Sample SO ARCHIVES OF CLINICAL NEUROPSYCHOLOGY LA English DT Article DE Symptom validity testing; Response bias; Memory Complaints Inventory ID NEUROPSYCHOLOGICAL STATUS RBANS; STATUS EFFORT INDEX; BIAS SCALE RBS; REPEATABLE BATTERY; GERIATRIC SAMPLE; BRAIN-INJURY; CHRONIC PAIN; IMPAIRMENT; FIBROMYALGIA; SENSITIVITY AB Previous work in a disability-seeking sample has demonstrated that as symptom validity test (SVT) scores decline, there is a corresponding increase in subjective reports of memory problems as measured by the Memory Complaints Inventory (MCI). The current archival study examined this relationship in a clinical sample of active and retired military service members and their adult family members without overt potential for secondary gain (n 191). General support for the previously evidenced relationship between SVT performances and MCI responses was found. Select MCI subscales (i.e., Amnesia for Complex Behavior and Amnesia for Antisocial Behavior) were not as strongly correlated with SVT scores as in the previously studied disability-seeking groups. The relationship between performances on an embedded effort measure and MCI scores was not nearly as robust as the relationship between MCI profiles and stand-alone SVTs. The potential clinical implications for these findings are discussed. C1 [Armistead-Jehle, Patrick] Munson Army Hlth Ctr, Dept Behav Hlth, Ft Leavenworth, KS 66027 USA. [Gervais, Roger O.] Univ Alberta, Dept Educ Psychol, Neurobehav Associates, Edmonton, AB T6G 2E1, Canada. RP Armistead-Jehle, P (reprint author), Munson Army Hlth Ctr, Dept Behav Hlth, 550 Pope Ave, Ft Leavenworth, KS 66027 USA. EM patrick.jehle@amedd.army.mil NR 49 TC 8 Z9 8 U1 2 U2 3 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 0887-6177 J9 ARCH CLIN NEUROPSYCH JI Arch. Clin. Neuropsychol. PD NOV PY 2012 VL 27 IS 7 BP 725 EP 734 DI 10.1093/arclin/acs071 PG 10 WC Psychology, Clinical; Psychology SC Psychology GA 024ZS UT WOS:000310152300004 PM 22885242 ER PT J AU Wang, WY Shang, SL Wang, Y Darling, KA Mathaudhu, SN Hui, XD Liu, ZK AF Wang, W. Y. Shang, S. L. Wang, Y. Darling, K. A. Mathaudhu, S. N. Hui, X. D. Liu, Z. K. TI Electron localization morphology of the stacking faults in Mg: A first-principles study SO CHEMICAL PHYSICS LETTERS LA English DT Article ID TOTAL-ENERGY CALCULATIONS; WAVE BASIS-SET; HCP METALS; MAGNESIUM; STRENGTH; ALUMINUM; DENSITY; ALLOY; GAS AB Electron localization morphologies of growth, deformation, and extrinsic faults of hcp Mg are calculated, yielding quantitative descriptions of charge transfer between atoms in and out of the stacking faults. We provide a physical interpretation of the relation between stacking fault energy and the difference of charge density and electron localization function between fault and non-fault planes and show that the stacking fault energy ascends in the order of growth, deformation, and extrinsic faults and is proportional to the square of the difference of maximum deformation charge density, the difference of maximum electron localization function, and the number of faulted layers. (C) 2012 Elsevier B.V. All rights reserved. C1 [Wang, W. Y.; Shang, S. L.; Wang, Y.; Liu, Z. K.] Penn State Univ, Dept Mat Sci & Engn, University Pk, PA 16802 USA. [Darling, K. A.] USA, Res Lab, Weap & Mat Res Directorate, RDRL WMM B, Aberdeen Proving Ground, MD 21005 USA. [Mathaudhu, S. N.] USA, Div Mat Sci, Res Off, Res Triangle Pk, NC 27709 USA. [Wang, W. Y.; Hui, X. D.] Univ Sci & Technol Beijing, State Key Lab Adv Met & Mat, Beijing 100083, Peoples R China. RP Wang, WY (reprint author), Penn State Univ, Dept Mat Sci & Engn, University Pk, PA 16802 USA. EM yuw129@psu.edu; xdhui@ustb.edu.cn; dr.liu@psu.edu RI Wang, William Yi/F-8212-2011; Wang, Yi/D-1032-2013; Shang, Shun-Li/A-6564-2009; Mathaudhu, Suveen/B-4192-2009; Liu, Zi-Kui/A-8196-2009 OI Wang, William Yi/0000-0002-8814-525X; Shang, Shun-Li/0000-0002-6524-8897; Liu, Zi-Kui/0000-0003-3346-3696 FU US Army Research Lab [W911NF-08-2-0064]; National Science Foundation in the United States [DMR-1006557]; National Natural Science Foundation of China [51071018]; Project Based Personnel Exchange Program; China Scholarship Council; American Academic Exchange Service [[2008] 3072]; NSF [OCI-0821527] FX This Letter was financially supported by the US Army Research Lab (Project No. W911NF-08-2-0064) and the National Science Foundation (Grant No. DMR-1006557) in the United States, National Natural Science Foundation of China (Grant Nos. 51071018). W. Y. Wang acknowledges the support from the Project Based Personnel Exchange Program with China Scholarship Council and American Academic Exchange Service ([2008] 3072). First-principles calculations were carried out on the LION clusters supported by the Materials Simulation Center and the Research Computing and Cyberinfrastructure unit at the Pennsylvania State University. Calculations were also carried out on the CyberStar cluster funded by NSF through grant OCI-0821527, and partially on resources of the National Supercomputer Center in Shenzhen. NR 41 TC 11 Z9 11 U1 5 U2 42 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0009-2614 J9 CHEM PHYS LETT JI Chem. Phys. Lett. PD NOV 1 PY 2012 VL 551 BP 121 EP 125 DI 10.1016/j.cplett.2012.09.028 PG 5 WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical SC Chemistry; Physics GA 027OK UT WOS:000310362200024 ER PT J AU Gaffney-Stomberg, E McClung, JP AF Gaffney-Stomberg, Erin McClung, James P. TI Inflammation and diminished iron status: mechanisms and functional outcomes SO CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE LA English DT Review DE cognition; hepcidin; inflammation; iron; obesity; physical performance ID REGULATORY HORMONE HEPCIDIN; PLACEBO-CONTROLLED TRIAL; FEMALE SOLDIERS; ENDURANCE CAPACITY; SERUM HEPCIDIN; ACUTE EXERCISE; DOUBLE-BLIND; WOMEN; HEMOJUVELIN; EXPRESSION AB Purpose of review To summarize recent findings regarding the effects of inflammation on iron (Fe) metabolism and to review studies detailing the influence of poor Fe status on physical and cognitive performance. Recent findings Hepatic expression and release of hepcidin, a negative regulator of Fe status, is increased by the actions of the inflammatory cytokine interleukin-6. Inflammation associated with chronic disease, obesity, and exercise is associated with elevated interleukin-6 and hepcidin levels, which may result in diminished Fe status. Summary Decrements in Fe status due to insufficient dietary Fe intake and/or the inflammatory response may degrade physical and cognitive performance. Future studies should clarify whether dietary or other therapeutic interventions to mitigate inflammation attenuate hepcidin-mediated declines in Fe status. C1 [Gaffney-Stomberg, Erin; McClung, James P.] USA, Environm Med Res Inst, Mil Nutr Div, Natick, MA 01760 USA. RP McClung, JP (reprint author), Kansas St,Bldg 42, Natick, MA 01760 USA. EM james.mcclung3@us.army.mil RI McClung, James/A-1989-2009 FU US Army Research Institute of Environmental Medicine FX This work was supported by an appointment to the Postgraduate Research Participation Program at the US Army Research Institute of Environmental Medicine administered by the Oak Ridge Institute for Science and Education (ORISE) through an interagency agreement between the US Department of Energy and the US Army Medical Research and Materiel Command (USAMRMC). NR 54 TC 15 Z9 16 U1 0 U2 20 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1363-1950 J9 CURR OPIN CLIN NUTR JI Curr. Opin. Clin. Nutr. Metab. Care PD NOV PY 2012 VL 15 IS 6 BP 605 EP 613 DI 10.1097/MCO.0b013e328357f63b PG 9 WC Endocrinology & Metabolism; Nutrition & Dietetics SC Endocrinology & Metabolism; Nutrition & Dietetics GA 027OI UT WOS:000310362000013 PM 23075938 ER PT J AU Knapik, J Montain, SJ McGraw, S Grier, T Ely, M Jones, BH AF Knapik, J. Montain, S. J. McGraw, S. Grier, T. Ely, M. Jones, B. H. TI Stress Fracture Risk Factors in Basic Combat Training SO INTERNATIONAL JOURNAL OF SPORTS MEDICINE LA English DT Article DE age; gender; body mass index; height; weight; race/ethnicity ID FEMALE ARMY RECRUITS; LIFE-STYLE FACTORS; HIP AXIS LENGTH; BONE-DENSITY; RACIAL-DIFFERENCES; MILITARY RECRUITS; INFANTRY RECRUITS; WOMEN; INJURIES; AMERICAN AB This study examined demographic and physical risk factors for stress fractures in a large cohort of basic trainees. New recruits participating in US Army BCT from 1997 through 2007 were identified, and birth year, race/ethnicity, physical characteristics, body mass index, and injuries were obtained from electronic databases. Injury cases were recruits medically diagnosed with inpatient or outpatient stress fractures. There were 475 745 men and 107 906 women. Stress fractures incidences were 19.3 and 79.9 cases/1000 recruits for men and women, respectively. Factors that increased stress fracture risk for both men and women included older age, lower body weight, lower BMI, and race/ethnicity other than black. Compared to Asians, those of white race/ethnicity were at higher stress fractures risk. In addition, men, but not women, who were taller or heavier were at increased stress fracture risk. Stress fracture risk generally increased with age (17-35 year range) at a rate of 2.2 and 3.9 cases/1000 recruits per year for men and women, respectively. This was the largest sample of military recruits ever examined for stress fractures and found that stress fracture risk was elevated among recruits who were female, older, had lower body weight, had lower BMI, and/or were not of black race/ethnicity. C1 [Knapik, J.; Grier, T.; Jones, B. H.] USA, Inst Publ Hlth, Aberdeen Proving Ground, MD USA. [Montain, S. J.; McGraw, S.; Ely, M.] USA, Environm Med Res Inst, Natick, MA 01760 USA. RP Knapik, J (reprint author), AIPH Injury Prevent, ATN MCHB TS DI, Aberdeen Proving Ground, MD 21010 USA. EM joseph.knapik@us.army.mil OI Ely, Matthew/0000-0002-0618-7078 NR 69 TC 28 Z9 28 U1 1 U2 22 PU GEORG THIEME VERLAG KG PI STUTTGART PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY SN 0172-4622 EI 1439-3964 J9 INT J SPORTS MED JI Int. J. Sports Med. PD NOV PY 2012 VL 33 IS 11 BP 940 EP 946 DI 10.1055/s-0032-1311583 PG 7 WC Sport Sciences SC Sport Sciences GA 027KY UT WOS:000310352300013 PM 22821178 ER PT J AU Lipinski, J Schneegans, S Sandamirskaya, Y Spencer, JP Schoner, G AF Lipinski, John Schneegans, Sebastian Sandamirskaya, Yulia Spencer, John P. Schoener, Gregor TI A Neurobehavioral Model of Flexible Spatial Language Behaviors SO JOURNAL OF EXPERIMENTAL PSYCHOLOGY-LEARNING MEMORY AND COGNITION LA English DT Article DE spatial cognition; spatial language; modeling; dynamical systems; reference frame ID DYNAMIC FIELD-THEORY; POSTERIOR PARIETAL CORTEX; PRIMARY VISUAL-CORTEX; MOVEMENT PREPARATION; WORKING-MEMORY; CORTICAL REPRESENTATIONS; COGNITIVE SCIENCE; POPULATION CODES; REFERENCE FRAME; ATTENTION AB We propose a neural dynamic model that specifies how low-level visual processes can be integrated with higher level cognition to achieve flexible spatial language behaviors. This model uses real-word visual input that is linked to relational spatial descriptions through a neural mechanism for reference frame transformations. We demonstrate that the system can extract spatial relations from visual scenes, select items based on relational spatial descriptions, and perform reference object selection in a single unified architecture. We further show that the performance of the system is consistent with behavioral data in humans by simulating results from 2 independent empirical studies, I spatial term rating task and 1 study of reference object selection behavior. The architecture we present thereby achieves a high degree of task flexibility under realistic stimulus conditions. At the same time, it also provides a detailed neural grounding for complex behavioral and cognitive processes. C1 [Lipinski, John; Schneegans, Sebastian; Sandamirskaya, Yulia; Schoener, Gregor] Ruhr Univ Bochum, Inst Neuroinformat, Bochum, Germany. [Spencer, John P.] Univ Iowa, Dept Psychol, Iowa City, IA 52242 USA. [Spencer, John P.] Univ Iowa, Delta Ctr, Iowa City, IA 52242 USA. RP Lipinski, J (reprint author), USA, Res Inst Behav & Social Sci, POB 52086, Ft Benning, GA 31995 USA. EM john.lipinski@us.army.mil; Sebastian.Schneegans@ini.ruhr-uni-bochum.de OI Sandamirskaya, Yulia/0000-0003-4684-202X; Schneegans, Sebastian/0000-0002-1246-2259 FU German Federal Ministry of Education [FKZ 0IGQ0951]; National Institutes of Health [Grant R01-MH062480] FX John Lipinski and Sebastian Schneegans contributed equally to this article and are listed alphabetically. We acknowledge support from the German Federal Ministry of Education and Research within the National Network Computational Neuroscience-Bernstein Focus: "Learning Behavioral Models: From Human Experiment to Technical Assistance," Grant FKZ 0IGQ0951. This work was also supported by National Institutes of Health Grant R01-MH062480 awarded to John P. Spencer. NR 84 TC 9 Z9 9 U1 0 U2 9 PU AMER PSYCHOLOGICAL ASSOC PI WASHINGTON PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA SN 0278-7393 J9 J EXP PSYCHOL LEARN JI J. Exp. Psychol.-Learn. Mem. Cogn. PD NOV PY 2012 VL 38 IS 6 BP 1490 EP 1511 DI 10.1037/a0022643 PG 22 WC Psychology; Psychology, Experimental SC Psychology GA 024RL UT WOS:000310126200002 PM 21517224 ER PT J AU Favini, E Agnihotra, S Surwade, SP Niezrecki, C Willis, D Chen, J Niemi, E Desabrais, K Charette, C Manohar, SK AF Favini, Eric Agnihotra, Srikanthrao Surwade, Sumedh P. Niezrecki, Christopher Willis, David Chen, Julie Niemi, Eugene Desabrais, Kenneth Charette, Christine Manohar, Sanjeev K. TI Sensing performance of electrically conductive fabrics and suspension lines for parachute systems SO JOURNAL OF INTELLIGENT MATERIAL SYSTEMS AND STRUCTURES LA English DT Article DE Smart parachute; integrated fabric sensor; structural health monitoring; carbon nanotube; polypyrrole; polyaniline ID FLEXIBLE STRAIN SENSOR; IN-SITU POLYMERIZATION; POLYANILINE; NANOFIBERS; COMPOSITE; TEXTILES AB The electronic sensing capabilities of parachute fabrics and suspension lines coated with conducting polymers, single-walled carbon nanotubes, and their composites are described. A new synthetic method is described to obtain a thin, strongly adhering coating of conducting polymers on commercial parachute fabrics and suspension lines using oligoanilines as an undercoating. The results indicate that both materials have a sensing ability; however, the coated suspension lines show superior performance compared to the coated parachute fabrics. C1 [Favini, Eric; Niezrecki, Christopher; Willis, David; Chen, Julie; Niemi, Eugene] Univ Massachusetts Lowell, Dept Mech Engn, Lowell, MA 01854 USA. [Agnihotra, Srikanthrao; Surwade, Sumedh P.] Univ Massachusetts Lowell, Dept Chem, Lowell, MA 01854 USA. [Desabrais, Kenneth; Charette, Christine] USA, Natick Soldier Res Dev & Engn Ctr, Warfighter Protect & Aerial Delivery Directorate, Natick, MA 01760 USA. [Manohar, Sanjeev K.] Univ Massachusetts Lowell, Dept Chem Engn, Lowell, MA 01854 USA. RP Niezrecki, C (reprint author), Univ Massachusetts Lowell, Dept Mech Engn, 1 Univ Ave, Lowell, MA 01854 USA. EM Christopher_Niezrecki@uml.edu FU Army's Natick Soldier Research, Development, and Engineering Center; NSRDEC FX This work was sponsored by a research grant from the Army's Natick Soldier Research, Development, and Engineering Center.; The authors are grateful for the funding, collaboration, and technical expertise provided by scientist Dr Calvin Lee from NSRDEC. The authors would also like to thank Dr Raymond Dunn for his expertise in testing the parachute cords. NR 27 TC 3 Z9 3 U1 1 U2 18 PU SAGE PUBLICATIONS LTD PI LONDON PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND SN 1045-389X J9 J INTEL MAT SYST STR JI J. Intell. Mater. Syst. Struct. PD NOV PY 2012 VL 23 IS 17 BP 1969 EP 1986 DI 10.1177/1045389X12453959 PG 18 WC Materials Science, Multidisciplinary SC Materials Science GA 027TU UT WOS:000310377300005 ER PT J AU Pilchak, AL Shiveley, AR Shade, PA Tiley, JS Ballard, DL AF Pilchak, A. L. Shiveley, A. R. Shade, P. A. Tiley, J. S. Ballard, D. L. TI Using cross-correlation for automated stitching of two-dimensional multi-tile electron backscatter diffraction data SO JOURNAL OF MICROSCOPY LA English DT Article DE EBSD; SEM; cross-correlation ID FIB-SEM; ORIENTATION; DIFFERENTIATION; DEFORMATION; SYSTEM; GRAIN AB A method for automatically aligning consecutive data sets of large, two-dimensional multi-tile electron backscatter diffraction (EBSD) scans with high accuracy was developed. The method involved first locating grain and phase boundaries within search regions containing overlapping data in adjacent scan tiles, and subsequently using cross-correlation algorithms to determine the relative position of the individual scan tiles which maximizes the fraction of overlapping boundaries. Savitzky-Golay filtering in two dimensions was used to estimate the background, which was then subtracted from the cross-correlation to enhance the peak signal in samples with a high density of interfaces. The technique was demonstrated on data sets with a range of interface densities. The equations were implemented as enhancements to a recently published open source code for stitching of multi-tile EBSD data sets. C1 [Pilchak, A. L.; Shiveley, A. R.; Shade, P. A.; Tiley, J. S.; Ballard, D. L.] USA, Res Lab, Mat & Mfg Directorate, RXLM, Wright Patterson AFB, OH USA. [Pilchak, A. L.; Shiveley, A. R.; Shade, P. A.] Universal Technol Corp, Dayton, OH USA. RP Pilchak, AL (reprint author), USA, Res Lab, Mat & Mfg Directorate, RXLM, Wright Patterson AFB, OH USA. EM adam.pilchak@wpafb.af.mil RI Shade, Paul/H-6459-2011 FU Air Force [FA8650-07-D-5800]; Institute for Science and Engineering Simulation [FA8650-08-C-5226] FX This work was performed as part of the in-house research activities of the Air Force Research Laboratory's Materials and Manufacturing Directorate. The support and encouragement of laboratory management and helpful discussions with Drs. M. Uchic and M. Groeber (AFRL/RXLM) are gratefully acknowledged. Three of the authors (ALP, ARS, PAS) were supported by Air Force Contract FA8650-07-D-5800 during the time this work was completed. This research was also partially supported by the Institute for Science and Engineering Simulation, Contract FA8650-08-C-5226. NR 24 TC 2 Z9 2 U1 1 U2 12 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0022-2720 J9 J MICROSC-OXFORD JI J. Microsc.. PD NOV PY 2012 VL 248 IS 2 BP 172 EP 186 DI 10.1111/j.1365-2818.2012.03661.x PG 15 WC Microscopy SC Microscopy GA 027GC UT WOS:000310339000008 PM 23078117 ER PT J AU Dunbar, ZW Chu, D AF Dunbar, Zachary W. Chu, Deryn TI Thin palladium membranes supported on microstructured nickel for purification of reformate gases SO JOURNAL OF POWER SOURCES LA English DT Article DE Fuel processing; Hydrogen purification; Palladium membrane; Fuel cell; Composite membrane ID HYDROGEN SEPARATION; ALLOY MEMBRANES; COMPOSITE MEMBRANES; PERMEATION; PD; DIFFUSION; REACTOR; SILVER AB Palladium membrane purification technology is a key unit operation to produce high purity hydrogen from a feedstock of hydrocarbon fuel. Palladium membrane technology has been investigated for many years. but designing affordable, leak free, and high flux membranes remains a challenge. Even more challenging are portable reforming applications where the membrane must integrate into fuel processing systems typically operating at much lower pressures than stationary industrial systems, in order to meet strict size, weight and rapid start-up requirements. In this work, a new supported palladium membrane composite structure is developed to meet the above challenges. Using microfabrication techniques, an ultra-thin palladium film supported on a microstructured nickel honeycomb is fabricated and characterized. The composite membrane is entirely metallic, highly selective and demonstrates flux rates of 0.47 mol of hydrogen per second per square meter of membrane area (140 standard cubic feet per hour per square) at 350 degrees C, using under 1 atm hydrogen partial pressure gradient driving force. (C) 2012 Elsevier BM. All rights reserved. C1 [Dunbar, Zachary W.; Chu, Deryn] USA, Res Lab, Adelphi, MD USA. RP Dunbar, ZW (reprint author), USA, Res Lab, Adelphi, MD USA. EM Zachary.dunbar.ctr@mail.mil NR 30 TC 4 Z9 4 U1 0 U2 18 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0378-7753 J9 J POWER SOURCES JI J. Power Sources PD NOV 1 PY 2012 VL 217 BP 47 EP 53 DI 10.1016/j.jpowsour.2012.05.044 PG 7 WC Chemistry, Physical; Electrochemistry; Energy & Fuels; Materials Science, Multidisciplinary SC Chemistry; Electrochemistry; Energy & Fuels; Materials Science GA 005XA UT WOS:000308782200008 ER PT J AU Grew, KN Brownlee, ZB Shukla, KC Chu, D AF Grew, Kyle N. Brownlee, Zachary B. Shukla, Kailash C. Chu, Deryn TI Assessment of Alane as a hydrogen storage media for portable fuel cell power sources SO JOURNAL OF POWER SOURCES LA English DT Article DE Portable; Alane; Hydrogen storage; Fuel cell ID METAL BOROHYDRIDES; ALUMINUM-HYDRIDE; POLYMORPHS; THERMODYNAMICS; ALCOHOLS; KINETICS; ALH3 AB Aluminum hydride (AlH3), often referred to as Alane, is examined as a hydrogen storage media for fuel cell-based portable power applications. The hydrogen storage capacity and thermally activated dehydrogenation of Mane makes it a candidate as a hydrogen storage material for portable fuel cell systems. In this study. Alane is found to provide a high gravimetric and volumetric energy density for portable power applications: however, there are significant challenges that must be addressed. These challenges include proper thermal control of the Alane dehydrogenation, fuel utilization and storage/treatment of excess hydrogen, and most importantly safety measures to prevent failure from an over-pressurization caused by excess hydrogen. (C) 2012 Elsevier B.V. All rights reserved. C1 [Grew, Kyle N.; Chu, Deryn] USA, Res Lab, Sensors & Electron Devices Directorate, RDRL SED C, Adelphi, MD 20783 USA. [Brownlee, Zachary B.] US Mil Acad, Dept Civil & Mech Engn, West Point, NY 10996 USA. [Shukla, Kailash C.] USA, Natick Soldier Syst Ctr, Natick, MA 01760 USA. RP Grew, KN (reprint author), USA, Res Lab, Sensors & Electron Devices Directorate, RDRL SED C, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM kyle.n.grew.ctr@mail.mil RI Grew, Kyle/K-3982-2013 OI Grew, Kyle/0000-0002-1645-3835 FU U.S. Department of the Army; U.S. Army Materiel Command; U.S. Army Research Laboratory [W911NF-12-2-0019] FX Financial support from the U.S. Department of the Army and U.S. Army Materiel Command are gratefully acknowledged. Research was supported, in part, by an appointment to the U.S. Army Research Laboratory Postdoctoral Fellowship Program administered by the Oak Ridge Associated Universities through Cooperative Agreement Number W911NF-12-2-0019. The authors also gratefully acknowledge support of ZBB's contributions to this work, through the U.S. Military Academy's Advanced Individual Advanced Development program. Discussions with Dr. Tony Thampan, U.S. Army Communications-Electronics Research, Development and Engineering Center (CERDEC), are gratefully acknowledged. NR 26 TC 8 Z9 9 U1 1 U2 29 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0378-7753 J9 J POWER SOURCES JI J. Power Sources PD NOV 1 PY 2012 VL 217 BP 417 EP 430 DI 10.1016/j.jpowsour.2012.06.007 PG 14 WC Chemistry, Physical; Electrochemistry; Energy & Fuels; Materials Science, Multidisciplinary SC Chemistry; Electrochemistry; Energy & Fuels; Materials Science GA 005XA UT WOS:000308782200061 ER PT J AU Villamaria, CY Rasmussen, TE Spencer, JR Patel, S Davis, MR AF Villamaria, Carole Y. Rasmussen, Todd E. Spencer, Jerry R. Patel, Shimul Davis, Michael R. TI Microvascular porcine model for the optimization of vascularized composite tissue transplantation SO JOURNAL OF SURGICAL RESEARCH LA English DT Article DE Composite tissue transplantation; Large animal model; Microvascular techniques; Ischemia; Reperfusion injury; Gracilis flap ID INJURY AB Background: Devastating extremity injuries are prevalent but most often survivable on the modern battlefield. The complexity of these injuries requires advanced methods of reconstruction. This study is designed to validate the feasibility of gracilis myocutaneous flap transplantation via microvascular free tissue transfer in a porcine model. This model will facilitate study of autotransplant physiology as well as vascularized composite allotransplantation as an evolving method for reconstructing previously nonreconstructable injuries. Material and methods: A donor gracilis myocutaneous flap is procured from Yorkshire swine. The right external carotid artery and internal jugular vein are prepared as the recipient axis for microvascular anastomoses. Group 1 undergoes immediate microvascular anastomosis with resultant 1-h ischemic period. Group 2 undergoes delayed anastomosis with 3-h ischemic period. Markers of ischemia-reperfusion injury are evaluated after anastomosis and on postoperative days 1, 2, 7, and 14. Results: A novel porcine model for microvascular composite tissue transplantation is demonstrated. Ischemia period-dependent elevations in circulating biomarkers (lactate dehydrogenase [LDH], creatine kinase [CK], and aspartate transaminase [AST]) demonstrate the effects of prolonged ischemia. Both groups showed marked LDH elevation without significant statistical intergroup difference (P = 0.250). The difference in CK and AST levels at 24 h showed strong significance (P < 0.0001). Conclusions: A novel method of vascularized gracilis myocutaneous flap transplantation was validated in the Yorkshire swine. Assays for skeletal muscle tissue injury (LDH, CK, and AST) showed ischemia period-dependent response providing assessment of ischemia-reperfusion injury at the cellular level. Subsequent studies will evaluate agents that mitigate ischemia-reperfusion injury and transition these findings to potentiate vascularized composite allotransplantation. Published by Elsevier Inc. C1 [Rasmussen, Todd E.; Davis, Michael R.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Villamaria, Carole Y.] Univ Texas Hlth Sci Ctr San Antonio, Dept Surg, San Antonio, TX 78229 USA. [Spencer, Jerry R.] 59MDW Sci & Technol Div, Joint Base San Antonio, TX USA. [Patel, Shimul] San Antonio Mil Med Ctr, Ft Sam Houston, TX USA. RP Davis, MR (reprint author), USA, Inst Surg Res, 3650 Chambers Pass,Bldg 3610, Ft Sam Houston, TX 78234 USA. EM michael.davis7@amedd.army.mil NR 13 TC 7 Z9 7 U1 0 U2 3 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0022-4804 J9 J SURG RES JI J. Surg. Res. PD NOV PY 2012 VL 178 IS 1 BP 452 EP 459 DI 10.1016/j.jss.2012.03.051 PG 8 WC Surgery SC Surgery GA 028UV UT WOS:000310450300067 PM 22651980 ER PT J AU Terry, FFN Marine, R Wang, CL Simmonds, P Kapusinszky, B Bodhidatta, L Oderinde, BS Wommack, KE Delwart, E AF Terry Fei Fan Ng Marine, Rachel Wang, Chunlin Simmonds, Peter Kapusinszky, Beatrix Bodhidatta, Ladaporn Oderinde, Bamidele Soji Wommack, K. Eric Delwart, Eric TI High Variety of Known and New RNA and DNA Viruses of Diverse Origins in Untreated Sewage SO JOURNAL OF VIROLOGY LA English DT Article ID HEPATITIS-E VIRUS; MULTIPLE SEQUENCE ALIGNMENT; AICHI VIRUS; MOLECULAR CHARACTERIZATION; ACUTE GASTROENTERITIS; METAGENOMIC ANALYSIS; FAMILY HEPEVIRIDAE; ENTERIC VIRUSES; COMPLETE GENOME; ACUTE DIARRHEA AB Deep sequencing of untreated sewage provides an opportunity to monitor enteric infections in large populations and for high-throughput viral discovery. A metagenomics analysis of purified viral particles in untreated sewage from the United States (San Francisco, CA), Nigeria (Maiduguri), Thailand (Bangkok), and Nepal (Kathmandu) revealed sequences related to 29 eukaryotic viral families infecting vertebrates, invertebrates, and plants (BLASTx E score, <10(-4)), including known pathogens (>90% protein identities) in numerous viral families infecting humans (Adenoviridae, Astroviridae, Caliciviridae, Hepeviridae, Parvoviridae, Picornaviridae, Picobirnaviridae, and Reoviridae), plants (Alphaflexiviridae, Betaflexiviridae, Partitiviridae, Sobemovirus, Secoviridae, Tombusviridae, Tymoviridae, Virgaviridae), and insects (Dicistroviridae, Nodaviridae, and Parvoviridae). The full and partial genomes of a novel kobuvirus, salivirus, and sapovirus are described. A novel astrovirus (casa astrovirus) basal to those infecting mammals and birds, potentially representing a third astrovirus genus, was partially characterized. Potential new genera and families of viruses distantly related to members of the single-stranded RNA picorna-like virus superfamily were genetically characterized and named Picalivirus, Secalivirus, Hepelivirus, Nedicistrovirus, Cadicistrovirus, and Niflavirus. Phylogenetic analysis placed these highly divergent genomes near the root of the picorna-like virus superfamily, with possible vertebrate, plant, or arthropod hosts inferred from nucleotide composition analysis. Circular DNA genomes distantly related to the plant-infecting Geminiviridae family were named Baminivirus, Nimivirus, and Niminivirus. These results highlight the utility of analyzing sewage to monitor shedding of viral pathogens and the high viral diversity found in this common pollutant and provide genetic information to facilitate future studies of these newly characterized viruses. C1 [Terry Fei Fan Ng; Kapusinszky, Beatrix; Delwart, Eric] Blood Syst Res Inst, San Francisco, CA USA. [Terry Fei Fan Ng; Kapusinszky, Beatrix; Delwart, Eric] Univ Calif San Francisco, Dept Lab Med, San Francisco, CA 94143 USA. [Marine, Rachel; Wommack, K. Eric] Univ Delaware, Delaware Biotechnol Inst, Dept Biol Sci, Newark, DE USA. [Marine, Rachel; Wommack, K. Eric] Univ Delaware, Delaware Biotechnol Inst, Dept Plant & Soil Sci, Newark, DE USA. [Wang, Chunlin] Stanford Univ, Stanford Genome Technol Ctr, Stanford, CA 94305 USA. [Simmonds, Peter] Univ Edinburgh, Ctr Immun Infect & Evolut, Edinburgh, Midlothian, Scotland. [Bodhidatta, Ladaporn] Armed Forces Res Inst Med Sci, Dept Enter Dis, Bangkok 10400, Thailand. [Oderinde, Bamidele Soji] Univ Maiduguri Teaching Hosp, WHO Natl Polio Lab, Maiduguri, Borno State, Nigeria. RP Delwart, E (reprint author), Blood Syst Res Inst, San Francisco, CA USA. EM delwarte@medicine.ucsf.edu RI Valle, Ruben/A-7512-2013; OI Marine, Rachel/0000-0002-3875-2959; Ng, Terry Fei Fan/0000-0002-4815-8697 FU NIH [R01HL083254, R01HL105770]; BSRI FX This work was supported by NIH grants R01HL083254 and R01HL105770 and funds from BSRI to E.D. NR 98 TC 0 Z9 1 U1 1 U2 36 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0022-538X J9 J VIROL JI J. Virol. PD NOV PY 2012 VL 86 IS 22 BP 12161 EP 12175 DI 10.1128/JVI.00869-12 PG 15 WC Virology SC Virology GA 027MK UT WOS:000310356400018 ER PT J AU Maegele, M Spinella, PC Schochl, H AF Maegele, Marc Spinella, Philip C. Schoechl, Herbert TI THE ACUTE COAGULOPATHY OF TRAUMA: MECHANISMS AND TOOLS FOR RISK STRATIFICATION SO SHOCK LA English DT Review DE Trauma; coagulopathy; mechanisms; scoring; stratification ID RED-BLOOD-CELLS; FRESH WHOLE-BLOOD; RECEIVING MASSIVE TRANSFUSIONS; LIFE-THREATENING HEMORRHAGE; COMBAT CASUALTIES; EARLY PREDICTION; INJURED PATIENT; SCORING SYSTEM; GLOBAL BURDEN; CLOT STRENGTH AB Trauma remains the leading cause of death, with bleeding as the primary cause of preventable mortality. When death occurs, it happens quickly, typically within the first 6 h after injury. The principal drivers of the acute coagulopathy of trauma have been characterized, but another group of patients with early evidence of coagulopathy both physiologically and mechanistically distinct from this systemic acquired coagulopathy has been identified. This distinct phenotype is present in 25% to 30% of patients with major trauma without being exposed to the traditional triggers and is associated with higher morbidity and a 4-fold increase in mortality. Despite improvements in the resuscitation of exsanguinating patients, one of the remaining keys is to expeditiously and reproducibly identify the patients most likely to require transfusion including massive transfusion with damage control resuscitation principles. Several predictive scoring systems/algorithms for transfusion including massive transfusion in both civilian and military trauma populations have been introduced. The models developed usually suggest combinations of physiologic, hemodynamic, laboratory, injury severity, and demographic triggers identified on the initial evaluation. Many use a combination of dichotomous variables that are readily accessible after the patient's arrival to the trauma bay, but others rely on time-consuming mathematical calculations and may thus have limited real-time application. Weighted and more sophisticated systems including higher numbers of variables perform superiorly. A common limitation to all models is their retrospective nature, and prospective validations are needed. Point-of-care viscoelastic testing may be an alternative to early recognize trauma-induced coagulopathy with the risk of ongoing hemorrhage and transfusion. C1 [Maegele, Marc] Univ Witten Herdecke, Cologne Merheim Med Ctr, Dept Traumatol & Orthoped Surg, D-51109 Cologne, Germany. [Maegele, Marc] Univ Witten Herdecke, Cologne Merheim Med Ctr, Inst Res Operat Med, D-51109 Cologne, Germany. [Spinella, Philip C.] Washington Univ, St Louis Childrens Hosp, Sch Med, St Louis, MO 63110 USA. [Spinella, Philip C.] Washington Univ, Crit Care Translat Res Program, Sch Med, St Louis, MO 63110 USA. [Spinella, Philip C.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Schoechl, Herbert] AUVA Trauma Hosp, Dept Anaesthesiol & Intens Care, Salzburg, Austria. [Schoechl, Herbert] Ludwig Boltzmann Inst Expt & Clin Traumatol, Vienna, Austria. RP Maegele, M (reprint author), Univ Witten Herdecke, Cologne Merheim Med Ctr, Dept Traumatol & Orthoped Surg, Ostmerheimerstr 200, D-51109 Cologne, Germany. EM Marc.Maegele@t-online.de NR 88 TC 29 Z9 31 U1 0 U2 15 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1073-2322 J9 SHOCK JI Shock PD NOV PY 2012 VL 38 IS 5 BP 450 EP 458 DI 10.1097/SHK.0b013e31826dbd23 PG 9 WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System & Cardiology GA 027QG UT WOS:000310367500002 PM 23042192 ER PT J AU Saunders, D Khemawoot, P Vanachayangkul, P Siripokasupkul, R Bethell, D Tyner, S Se, Y Rutvisuttinunt, W Sriwichai, S Chanthap, L Lin, J Timmermans, A Socheat, D Ringwald, P Noedl, H Smith, B Fukuda, M Teja-Isavadharm, P AF Saunders, David Khemawoot, Phisit Vanachayangkul, Pattaraporn Siripokasupkul, Raveewan Bethell, Delia Tyner, Stuart Se, Youry Rutvisuttinunt, Wiriya Sriwichai, Sabaithip Chanthap, Lon Lin, Jessica Timmermans, Ans Socheat, Doung Ringwald, Pascal Noedl, Harald Smith, Bryan Fukuda, Mark Teja-Isavadharm, Paktiya TI Pharmacokinetics and Pharmacodynamics of Oral Artesunate Monotherapy in Patients with Uncomplicated Plasmodium falciparum Malaria in Western Cambodia SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY LA English DT Article ID HEALTHY-VOLUNTEERS; ARTEMISININ RESISTANCE; POPULATION PHARMACOKINETICS; DIHYDROARTEMISININ; PROTEIN; PHARMACOLOGY; COMBINATION; METABOLISM; ARTEMETHER; EFFICACY AB Artemisinin-resistant malaria along the Thailand-Cambodian border is an important public health concern, yet mechanisms of drug action and their contributions to the development of resistance are poorly understood. The pharmacokinetics and pharmacodynamics of oral artesunate monotherapy were explored in a dose-ranging trial in an area of emerging artesunate resistance in western Cambodia. We enrolled 143 evaluable subjects with uncomplicated Plasmodium falciparum malaria in an open label study of directly observed artesunate monotherapy at 3 dose levels (2, 4, and 6 mg/kg of body weight/day) for 7 days at Tasanh Health Center, Tasanh, Cambodia. Clinical outcomes were similar among the 3 groups. Wide variability in artesunate and dihydroartemisinin concentrations in plasma was observed. No significant dose-effect or concentration-effect relationships between pharmacokinetic (PK) and parasite clearance parameters were observed, though baseline parasitemia was modestly correlated with increased parasite clearance times. The overall parasite clearance times were prolonged compared with the clearance times in a previous study at this site in 2006 to 2007, but this did not persist when the evaluation was limited to subjects with a comparable artesunate dose (4 mg/kg/day) and baseline parasitemia from the two studies. Reduced plasma drug levels with higher presentation parasitemias, previously hypothesized to result from partitioning into infected red blood cells, was not observed in this population with uncomplicated malaria. Neither in vitro parasite susceptibility nor plasma drug concentrations appeared to have a direct relationship with the pharmacodynamic (PD) effects of oral artesunate on malaria parasites. While direct concentration-effect relationships were not found, it remains possible that a population PK modeling approach that allows modeling of greater dose separation might discern more-subtle relationships. C1 [Saunders, David; Khemawoot, Phisit; Vanachayangkul, Pattaraporn; Siripokasupkul, Raveewan; Bethell, Delia; Tyner, Stuart; Se, Youry; Rutvisuttinunt, Wiriya; Sriwichai, Sabaithip; Chanthap, Lon; Timmermans, Ans; Teja-Isavadharm, Paktiya] Armed Forces Res Inst Med Sci AFRIMS, Dept Immunol & Med, Bangkok, Thailand. [Socheat, Doung] Natl Ctr Parasitol Entomol & Malaria Control CNM, Phnom Penh, Cambodia. [Ringwald, Pascal] World Hlth Org, Drug Resistance & Containment Global Malaria Prog, Geneva, Switzerland. [Lin, Jessica] Univ N Carolina, Chapel Hill, NC USA. [Noedl, Harald] Med Univ Vienna, Vienna, Austria. [Smith, Bryan] US Army Med Mat Dev Act, Ft Detrick, MD USA. [Fukuda, Mark] Armed Forces Hlth Surveillance Ctr, Silver Spring, MD USA. [Khemawoot, Phisit] Chulalongkorn Univ, Fac Pharmaceut Sci, Bangkok, Thailand. RP Saunders, D (reprint author), Armed Forces Res Inst Med Sci AFRIMS, Dept Immunol & Med, Bangkok, Thailand. EM david.saunders@afrims.org RI Valle, Ruben/A-7512-2013 FU U.S. Army Research and Materiel Command; Bill & Melinda Gates Foundation through the World Health Organization [48821]; Global Emerging Infections Surveillance and Response System (a Division of the Armed Forces Health Surveillance Center) FX This study was supported by the U.S. Army Research and Materiel Command. This study was funded by the Bill & Melinda Gates Foundation through the World Health Organization (grant 48821) and the Global Emerging Infections Surveillance and Response System (a Division of the Armed Forces Health Surveillance Center). P.R. is a staff member of the World Health Organization. NR 40 TC 14 Z9 14 U1 0 U2 12 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0066-4804 J9 ANTIMICROB AGENTS CH JI Antimicrob. Agents Chemother. PD NOV PY 2012 VL 56 IS 11 BP 5484 EP 5493 DI 10.1128/AAC.00044-12 PG 10 WC Microbiology; Pharmacology & Pharmacy SC Microbiology; Pharmacology & Pharmacy GA 023SN UT WOS:000310055800007 PM 22869581 ER PT J AU Roy, TC Knapik, JJ Ritland, BM Murphy, N Sharp, MA AF Roy, Tanja C. Knapik, Joseph J. Ritland, Bradley M. Murphy, Nicole Sharp, Marilyn A. TI Risk Factors for Musculoskeletal Injuries for Soldiers Deployed to Afghanistan SO AVIATION SPACE AND ENVIRONMENTAL MEDICINE LA English DT Article DE pain; military; deployment ID OPERATION IRAQI FREEDOM; PHYSICAL-FITNESS; INFANTRY SOLDIERS; LOAD DISTRIBUTION; BODY-COMPOSITION; MILITARY; BACK; PAIN; PREVENTION; MASS AB ROY TC, KNAPIK JJ, RITLAND BM, MURPHY N, SHARP MA. Risk factors for musculoskeletal injuries for soldiers deployed to Afghanistan. Aviat Space Environ Med 2012; 83:1060-6. Purpose: This study determined injury incidence and examined the association between musculoskeletal injuries and potential intrinsic and extrinsic risk factors. Methods: This retrospective cohort study involved a survey of 593 volunteers from two battalions of a Stryker Brigade Combat Team upon completion of a 12-mo deployment to Afghanistan. The survey included questions on physical characteristics, work duties, equipment worn, fitness training, and injuries experienced during the deployment. Results: Of the surveyed soldiers, 45% sustained an injury during the deployment. Total injuries resulted in 5049 d of limited duty, an average of 8.5 d per injury. The body regions with the largest numbers of injuries were the low back (17.4%), knee (12.7%), and shoulder (10.0%). The majority (65%) of injuries occurred while working. The most frequent activities soldiers reported as the cause of injury were lifting and carrying (9.8%), dismounted patrolling (9.6%), and physical training (8.0%). Older age, higher enlisted rank, female sex, months deployed, more time spent standing, longer strength training sessions, heaviest load worn, and heavier or more frequent lifting tasks were all associated with injury. Discussion: Tasks requiring physical energy expenditure such as load carriage, lifting, or standing resulted in an increased risk of musculoskeletal injury in this study. Lifting/carrying, dismounted patrols, and physical training were associated with 26% of musculoskeletal injuries. The weight of loads carried and lifting may be exceeding the work capacity of the soldiers, resulting in injury. These injuries in turn limit available work days for military units, reducing combat power. C1 [Roy, Tanja C.; Knapik, Joseph J.; Ritland, Bradley M.; Murphy, Nicole; Sharp, Marilyn A.] USA, Environm Med Res Inst, Natick, MA 01760 USA. RP Roy, TC (reprint author), 15 Kansas St, Natick, MA USA. EM Tanja.roy@us.army.mil NR 25 TC 23 Z9 26 U1 2 U2 18 PU AEROSPACE MEDICAL ASSOC PI ALEXANDRIA PA 320 S HENRY ST, ALEXANDRIA, VA 22314-3579 USA SN 0095-6562 J9 AVIAT SPACE ENVIR MD JI Aviat. Space Environ. Med. PD NOV PY 2012 VL 83 IS 11 BP 1060 EP 1066 DI 10.3357/ASEM.3341.2012 PG 7 WC Public, Environmental & Occupational Health; Medicine, General & Internal; Sport Sciences SC Public, Environmental & Occupational Health; General & Internal Medicine; Sport Sciences GA 025IL UT WOS:000310182100006 PM 23156094 ER PT J AU Vinnakota, CV Peetha, NS Perrizo, MG Ferris, DG Oda, RP Rockwood, GA Logue, BA AF Vinnakota, Chakravarthy V. Peetha, Naga S. Perrizo, Mitch G. Ferris, David G. Oda, Robert P. Rockwood, Gary A. Logue, Brian A. TI Comparison of cyanide exposure markers in the biofluids of smokers and non-smokers SO BIOMARKERS LA English DT Article DE Chemical warfare agents; cyanide exposure; gas chromatography mass spectrometry; high performance liquid chromatography ID METABOLITE 2-AMINOTHIAZOLINE-4-CARBOXYLIC ACID; PERFORMANCE LIQUID-CHROMATOGRAPHY; GAS-CHROMATOGRAPHY; TOBACCO-SMOKE; WHOLE-BLOOD; MASS SPECTROMETRY; HYDROGEN-CYANIDE; BODY-FLUIDS; THIOCYANATE; PLASMA AB Cyanide is highly toxic and is present in many foods, combustion products (e. g. cigarette smoke), industrial processes, and has been used as a terrorist weapon. In this study, cyanide and its major metabolites, thiocyanate and 2-amino-2-thiazoline-4-carboxylic acid (ATCA), were analyzed from various human biofluids of smokers (low-level chronic cyanide exposure group) and non-smokers to gain insight into the relationship of these biomarkers to cyanide exposure. The concentrations of each biomarker tested were elevated for smokers in each biofluid. Significant differences (p < 0.05) were found for thiocyanate in plasma and urine, and ATCA showed significant differences in plasma and saliva. Additionally, biomarker concentration ratios, correlations between markers of cyanide exposure, and other statistical methods were performed to better understand the relationship between cyanide and its metabolites. Of the markers studied, the results indicate plasma ATCA, in particular, showed excellent promise as a biomarker for chronic low-level cyanide exposure. C1 [Vinnakota, Chakravarthy V.; Peetha, Naga S.; Perrizo, Mitch G.; Ferris, David G.; Oda, Robert P.; Logue, Brian A.] S Dakota State Univ, Dept Chem & Biochem, Brookings, SD 57007 USA. [Rockwood, Gary A.] USA, Analyt Toxicol Div, Med Res Inst Chem Def, Aberdeen Proving Ground, MD USA. RP Logue, BA (reprint author), S Dakota State Univ, Dept Chem & Biochem, SAV131,Box 2202, Brookings, SD 57007 USA. EM brian.logue@sdstate.edu FU CounterACT Program, National Institutes Of Health Office of the Director; National Institute of Allergy and Infectious Diseases [Y1-A1-6176-03/A120-B.P2008-01, Y1-0D-9611-01/A120-B.P2009-01]; US Army Medical Research Institute of Chemical Defense under US Army Research Office of Scientific Services Program [W911NF-11-D-0001, DAAD19-02-D-0001] FX The research was supported by the CounterACT Program, National Institutes Of Health Office of the Director and the National Institute of Allergy and Infectious Diseases, Inter Agency Agreement Numbers Y1-A1-6176-03/A120-B.P2008-01 and Y1-0D-9611-01/A120-B.P2009-01 and the US Army Medical Research Institute of Chemical Defense under the auspices of the US Army Research Office of Scientific Services Program Contract No. W911NF-11-D-0001 administered by Battelle (Delivery order 399, Contract No DAAD19-02-D-0001). The authors report no declaration of interest. NR 55 TC 7 Z9 7 U1 2 U2 48 PU INFORMA HEALTHCARE PI LONDON PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND SN 1354-750X EI 1366-5804 J9 BIOMARKERS JI Biomarkers PD NOV PY 2012 VL 17 IS 7 BP 625 EP 633 DI 10.3109/1354750X.2012.709880 PG 9 WC Biotechnology & Applied Microbiology; Toxicology SC Biotechnology & Applied Microbiology; Toxicology GA 023ZQ UT WOS:000310077200007 PM 22889346 ER PT J AU Dew, ITZ Buchler, N Dobbins, IG Cabeza, R AF Dew, Ilana T. Z. Buchler, Norbou Dobbins, Ian G. Cabeza, Roberto TI Where Is ELSA? The Early to Late Shift in Aging SO CEREBRAL CORTEX LA English DT Article DE episodic memory; fMRI; medial temporal lobe; older adults; retrieval preparation ID AGE-RELATED DIFFERENCES; MEDIAL TEMPORAL-LOBE; POSITRON-EMISSION-TOMOGRAPHY; PREFRONTAL CORTEX ACTIVITY; EPISODIC MEMORY RETRIEVAL; EVENT-RELATED FMRI; OLDER-ADULTS; RECOGNITION MEMORY; WORKING-MEMORY; FUNCTIONAL NEUROANATOMY AB Studies of cognitive and neural aging have recently provided evidence of a shift from an early- to late-onset cognitive control strategy, linked with temporally extended activity in the prefrontal cortex (PFC). It has been uncertain, however, whether this age-related shift is unique to PFC and executive control tasks or whether the functional location might vary depending on the particular cognitive processes that are altered. The present study tested whether an early-to-late shift in aging (ELSA) might emerge in the medial temporal lobes (MTL) during a protracted context memory task comprising both anticipatory cue (retrieval preparation) and retrieval probe (retrieval completion) phases. First, we found reduced MTL activity in older adults during the early retrieval preparation phase coupled with increased MTL activity during the late retrieval completion phase. Second, we found that functional connectivity between MTL and PFC regions was higher during retrieval preparation in young adults but higher during retrieval completion in older adults, suggesting an important interactive relationship between the ELSA pattern in MTL and PFC. Taken together, these results critically suggest that aging results in temporally lagged activity even in regions not typically associated with cognitive control, such as the MTL. C1 [Dew, Ilana T. Z.; Cabeza, Roberto] Duke Univ, Ctr Cognit Neurosci, Durham, NC 27708 USA. [Buchler, Norbou] USA, Cognit Sci Branch, Res Lab, Aberdeen Proving Ground, MD 21005 USA. [Dobbins, Ian G.] Washington Univ, Dept Psychol, St Louis, MO 63130 USA. RP Dew, ITZ (reprint author), Duke Univ, Ctr Cognit Neurosci, LSRC B254,Box 90999, Durham, NC 27708 USA. EM ilana.dew@duke.edu FU National Institute on Aging at the National Institutes of Health [AG19731, AG23770]; National Institute of Mental Health at the National Institutes of Health [MH073982] FX National Institute on Aging at the National Institutes of Health (AG19731 and AG23770 to R. C.); National Institute of Mental Health at the National Institutes of Health (MH073982 to I.G.D.). NR 75 TC 15 Z9 15 U1 2 U2 18 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 1047-3211 J9 CEREB CORTEX JI Cereb. Cortex PD NOV PY 2012 VL 22 IS 11 BP 2542 EP 2553 DI 10.1093/cercor/bhr334 PG 12 WC Neurosciences SC Neurosciences & Neurology GA 018XH UT WOS:000309700700008 PM 22114083 ER PT J AU Marcellin, P Roberts, SK Reddy, KR Harrison, SA Jensen, DM Hadziyannis, S Diago, M Weltman, M Messinger, D Tatsch, F Rizzetto, M AF Marcellin, Patrick Roberts, Stuart K. Reddy, K. Rajender Harrison, Stephen A. Jensen, Donald M. Hadziyannis, Stephanos Diago, Moises Weltman, Martin Messinger, Diethelm Tatsch, Fernando Rizzetto, Mario TI Safety profile of standard- vs. high-dose peginterferon alfa-2a plus standard-dose ribavirin in HCV genotype 1/4 patients: pooled analysis from 5 randomized studies SO EXPERT OPINION ON DRUG SAFETY LA English DT Review DE hepatitis C; high dose induction; peginterferon alfa-2a; safety ID CHRONIC HEPATITIS-C; VIRUS-INFECTION; VIROLOGICAL RESPONSE; COMBINATION THERAPY; PEGYLATED INTERFERON; RETREATMENT; TRIAL; NEUTROPENIA; DEPRESSION; INDUCTION AB Objective: This analysis examines the safety profile of standard-versus high-dose peginterferon alfa-2a. Methods: Data were pooled from five trials including HCV genotype 1- or 4-infected naive and treatment-experienced patients (n = 2,940). Patients were randomized to receive peginterferon alfa-2a at 180 mu g/week (standard-dose; n = 1,672) or 360 mu g/week (high-dose; n = 1,268) plus ribavirin 1,000/1,200 mg/day for 12 weeks; after 12 weeks, all received standard dose. This safety analysis was restricted to the first 12 weeks. Results: In standard and high-dose groups, similar frequencies of serious adverse events (SAEs, 3.2 and 4.2%, respectively) and treatment discontinuations for safety reasons (2.8 and 2.9%) were reported. More patients reported weight decrease as an adverse event (AE) in the 360 mu g/week group (7.7 vs. 3.3%). Significant (p < 0.05) independent predictors for discontinuation due to safety were older age, male gender, lower albumin and low neutrophil count, but not the starting dose of peginterferon alfa-2a. Although more laboratory abnormalities were reported in patients receiving high-dose peginterferon alfa-2a, this was not reflected in AEs or discontinuations, suggesting these are adequately managed by dose modification. Conclusions: High-dose peginterferon alfa-2a for 12 weeks does not significantly increase the incidence of SAEs or discontinuations for safety reasons, beyond that of a standard dose regimen. C1 [Marcellin, Patrick] Hop Beaujon, F-92110 Clichy, France. [Roberts, Stuart K.] Alfred Hosp, Prahran, Vic, Australia. [Reddy, K. Rajender] Univ Penn, Philadelphia, PA 19104 USA. [Harrison, Stephen A.] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. [Jensen, Donald M.] Ctr Liver Dis, Chicago, IL USA. [Hadziyannis, Stephanos] Henry Dunant Hosp, Athens, Greece. [Diago, Moises] Hosp Gen Valencia, Valencia, Spain. [Weltman, Martin] Nepean Hosp, Sydney, NSW, Australia. [Messinger, Diethelm] IST GmbH, Mannheim, Germany. [Tatsch, Fernando] Roche, Basel, Switzerland. [Rizzetto, Mario] Univ Turin, Turin, Italy. RP Marcellin, P (reprint author), Hop Beaujon, 100 Blvd Gen Leclerc, F-92110 Clichy, France. EM patrick.marcellin@bjn.aphp.fr FU Roche; Schering-Plough; Gilead; Boehringer-Ingelheim; Genentech/Roche; Tibotec; Vertex; Schering Plough FX Support for third-party writing assistance for this manuscript was provided by F. Hoffmann-La Roche Ltd. P Marcellin reports acting as a consultant for Roche, Schering-Plough, Gilead, BMS, Vertex, Novartis, Tibotec, MSD, Boehringer, Biolex and InterMune; has received grant/research support from Roche, Schering-Plough and Gilead; and has been involved as a speaker for Roche, Schering-Plough, Gilead, BMS, Vertex, Novartis, Pharmasset, Tibotec, MSD, Biolex, InterMune, and Zymogenetics. KR Reddy reports involvement on advisory committees/review panels for Schering Plough, Roche, Vertex, Salix, Gore, and Otsuka. SA Harrison reports being involved as a speaker for BMS. DM Jensen reports involvement on advisory committees/review panels for Abbott, Boehringer-Ingelheim, Genentech/Roche, GlobeImmune, Tibotec, Vertex, Human Genome Sciences and Pharmasset; and has received grant/research support from Boehringer-Ingelheim, Genentech/Roche, Tibotec and Vertex. S Hadziyannis reports involvement on advisory committees/review panels for Gilead, Bristol-Myers Squibb and Novartis; and has received grant/research support from Roche, Gilead and Schering Plough; and has been involved as a speaker for Roche. M Weltman reports involvement on advisory committees/review panels for Roche, Novartis, Janssen and Cillag; and has been involved as a speaker for Roche, MSD and Bristol-Myers Squibb. D Messinger reports serving as a consultant for Roche. F Tatsch is an employee of F. Hoffmann-La Roche Ltd. SK Roberts, M Diago and M Rizzetto have nothing to disclose. NR 30 TC 4 Z9 4 U1 0 U2 0 PU INFORMA HEALTHCARE PI LONDON PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND SN 1474-0338 J9 EXPERT OPIN DRUG SAF JI Expert Opin. Drug Saf. PD NOV PY 2012 VL 11 IS 6 BP 901 EP 909 DI 10.1517/14740338.2012.721927 PG 9 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA 023ZO UT WOS:000310076900005 PM 22943161 ER PT J AU Butzin, XY Troiano, AJ Coleman, WH Griffiths, KK Doona, CJ Feeherry, FE Wang, GW Li, YQ Setlow, P AF Butzin, Xuan Yi Troiano, Anthony J. Coleman, William H. Griffiths, Keren K. Doona, Christopher J. Feeherry, Florence E. Wang, Guiwen Li, Yong-qing Setlow, Peter TI Analysis of the Effects of a gerP Mutation on the Germination of Spores of Bacillus subtilis SO JOURNAL OF BACTERIOLOGY LA English DT Article ID CORTEX LYTIC ENZYMES; GENOME-WIDE ANALYSIS; BACTERIAL-SPORES; ALANINE RACEMASE; NUTRIENT RECEPTORS; SPORULATION GENES; ANTHRACIS SPORES; DIPICOLINIC ACID; PROTEIN-LEVELS; HIGH-PRESSURE AB As previously reported, gerP Bacillus subtilis spores were defective in nutrient germination triggered via various germinant receptors (GRs), and the defect was eliminated by severe spore coat defects. The gerP spores' GR-dependent germination had a longer lag time between addition of germinants and initiation of rapid release of spores' dipicolinic acid (DPA), but times for release of >90% of DPA from individual spores were identical for wild-type and gerP spores. The gerP spores were also defective in GR-independent germination by DPA with its associated Ca2+ divalent cation (CaDPA) but germinated better than wild-type spores with the GR-independent germinant dodecylamine. The gerP spores exhibited no increased sensitivity to hypochlorite, suggesting that these spores have no significant coat defect. Overexpression of GRs in gerP spores did lead to faster germination via the overexpressed GR, but this was still slower than germination of comparable gerP(+) spores. Unlike wild-type spores, for which maximal nutrient germinant concentrations were between 500 mu M and 2 mM for L-alanine and <= 10 mM for L-valine, rates of gerP spore germination increased up to between 200 mM and 1 M L-alanine and 100 mM L-valine, and at 1 M L-alanine, the rates of germination of wild-type and gerP spores with or without all alanine racemases were almost identical. A high pressure of 150 MPa that triggers spore germination by activating GRs also triggered germination of wild-type and gerP spores identically. All these results support the suggestion that GerP proteins facilitate access of nutrient germinants to their cognate GRs in spores' inner membrane. C1 [Butzin, Xuan Yi; Troiano, Anthony J.; Coleman, William H.; Griffiths, Keren K.; Setlow, Peter] Univ Connecticut, Ctr Hlth, Dept Mol Microbial & Struct Biol, Farmington, CT USA. [Doona, Christopher J.; Feeherry, Florence E.] USA, Natick Soldier RD&E Ctr, Warfighter Directorate, Natick, MA 01760 USA. [Wang, Guiwen; Li, Yong-qing] E Carolina Univ, Dept Phys, Greenville, NC 27858 USA. RP Setlow, P (reprint author), Univ Connecticut, Ctr Hlth, Dept Mol Microbial & Struct Biol, Farmington, CT USA. EM setlow@nso2.uchc.edu FU Multi-University Research Initiative award through the U.S. Army Research Laboratory; Multi-University Research Initiative award through the Army Research Office [W911NF-09-1-0286] FX This work was supported by a Multi-University Research Initiative award through the U.S. Army Research Laboratory and the Army Research Office under contract number W911NF-09-1-0286. NR 50 TC 16 Z9 16 U1 0 U2 8 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0021-9193 J9 J BACTERIOL JI J. Bacteriol. PD NOV PY 2012 VL 194 IS 21 BP 5749 EP 5758 DI 10.1128/JB.01276-12 PG 10 WC Microbiology SC Microbiology GA 022VB UT WOS:000309990800004 PM 22904285 ER PT J AU Siaki, LA Loescher, LJ Ritter, L AF Siaki, Leilani A. Loescher, Lois J. Ritter, Leslie TI A Cultural Perspective of Samoans' Perceived Risk of Cardiovascular Disease and Diabetes SO JOURNAL OF CARDIOVASCULAR NURSING LA English DT Article DE cardiovascular disease; diabetes; Pacific Islanders; perceived risk ID METABOLIC SYNDROME; PACIFIC ISLANDERS; HEART-DISEASE; PERCEPTION; WOMEN; BEHAVIOR; PEOPLE; MEN AB Background: Cardiovascular disease (CVD) and diabetes, which are leading causes of morbidity and mortality in the United States, have a high incidence among Pacific Islanders. Risk of these conditions increases in the presence of metabolic syndrome. Risk-reducing behaviors for CVD and diabetes are driven partly by perceived risk of health threats and their consequences. Perceived risk is influenced by sociocultural beliefs and is a component of some health behavior models, yet it is understudied in Pacific Islanders. Objective: This mixed-methods study explored the perceived risk of CVD and diabetes in at-risk Samoan Pacific Islanders. Subjects and Methods: We used culturally sensitive strategies to recruit and enroll 43 adult Samoans from a community setting in Hawaii. Participants were obese with at least 1 other component of metabolic syndrome. Their objective risk was determined by the National Cholesterol Education Program Adult Treatment Program III risk categories. Participants provided demographic and health history information and answered 2 quantitative perceived risk questions. They also participated in 1 of 7 focus groups-the source of perceived risk qualitative data. Quantitative and qualitative data were analyzed using descriptive statistics and content analysis, respectively. The mixed-methods analysis targeted points of data convergence and complementarity for the 2 methods. Results: More than 80% of participants who were at moderately high (10%-20%) objective risk for CVD and diabetes had high (>20%) perceived risk of these conditions. There was high concordance of perceived risk for CVD and diabetes (P < .05). Qualitative data revealed bidirectional codes that influenced and were influenced by perceived risk within the participants' cultural perspective: current and planned health behavior, physical health, and family history of CVD or diabetes. Conclusion: Using mixed methods facilitated better understanding of cultural perspectives of perceived risk of CVD and diabetes. These results provide a foundation for developing culturally appropriate interventions targeting CVD and diabetes risk reduction in Samoans. C1 [Siaki, Leilani A.] USA, Pacific Reg Med Command, Nurse Corps, Kapolei, HI 96707 USA. [Loescher, Lois J.; Ritter, Leslie] Univ Arizona, Coll Nursing, Tucson, AZ 85721 USA. RP Siaki, LA (reprint author), USA, Pacific Reg Med Command, Nurse Corps, 92-917 Welo St,Unit 107, Kapolei, HI 96707 USA. EM leilani.a.siaki@us.army.mil FU National Institutes of Health [K07CA106996] FX Dr Loescher's work on this article was supported by National Institutes of Health grant K07CA106996. NR 40 TC 2 Z9 2 U1 2 U2 14 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0889-4655 J9 J CARDIOVASC NURS JI J. Cardiovasc. Nurs. PD NOV-DEC PY 2012 VL 27 IS 6 BP 468 EP 475 DI 10.1097/JCN.0b013e31822b9be3 PG 8 WC Cardiac & Cardiovascular Systems; Nursing SC Cardiovascular System & Cardiology; Nursing GA 022MZ UT WOS:000309964800011 PM 21912273 ER PT J AU Grujicic, M Pandurangan, B Yen, CF Cheeseman, BA AF Grujicic, M. Pandurangan, B. Yen, C. -F. Cheeseman, B. A. TI Modifications in the AA5083 Johnson-Cook Material Model for Use in Friction Stir Welding Computational Analyses SO JOURNAL OF MATERIALS ENGINEERING AND PERFORMANCE LA English DT Article DE AA5083; friction stir welding; Johnson-Cook material model ID FINITE-ELEMENT SIMULATION; MATERIAL FLOW; MICROSTRUCTURE EVOLUTION; ALUMINUM AB Johnson-Cook strength material model is frequently used in finite-element analyses of various manufacturing processes involving plastic deformation of metallic materials. The main attraction to this model arises from its mathematical simplicity and its ability to capture the first-order metal-working effects (e.g., those associated with the influence of plastic deformation, rate of deformation, and the attendant temperature). However, this model displays serious shortcomings when used in the engineering analyses of various hot-working processes (i.e., those utilizing temperatures higher than the material recrystallization temperature). These shortcomings are related to the fact that microstructural changes involving: (i) irreversible decrease in the dislocation density due to the operation of annealing/recrystallization processes; (ii) increase in grain-size due to high-temperature exposure; and (iii) dynamic-recrystallization-induced grain refinement are not accounted for by the model. In this study, an attempt is made to combine the basic physical-metallurgy principles with the associated kinetics relations to properly modify the Johnson-Cook material model, so that the model can be used in the analyses of metal hot-working and joining processes. The model is next used to help establish relationships between process parameters, material microstructure and properties in friction stir welding welds of AA5083 (a non-age-hardenable, solid-solution strengthened, strain-hardened/stabilized Al-Mg-Mn alloy). C1 [Grujicic, M.; Pandurangan, B.] Clemson Univ, Dept Mech Engn, Clemson, SC 29634 USA. [Yen, C. -F.; Cheeseman, B. A.] USA, Res Lab, Survivabil Mat Branch, Aberdeen Proving Ground, MD 21005 USA. RP Grujicic, M (reprint author), Clemson Univ, Dept Mech Engn, 241 Engn Innovat Bldg, Clemson, SC 29634 USA. EM mica.grujicic@ces.clemson.edu FU Army Research Office [W911NF-11-1-0207, W911NF-09-1-0513]; U.S. Army/Clemson University [W911NF-04-2-0024, W911NF-06-2-0042] FX The material presented in this paper is based on work supported by two Army Research Office sponsored grants (W911NF-11-1-0207 and W911NF-09-1-0513) and two U.S. Army/Clemson University Cooperative Agreements (W911NF-04-2-0024 and W911NF-06-2-0042). NR 24 TC 21 Z9 21 U1 1 U2 29 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1059-9495 J9 J MATER ENG PERFORM JI J. Mater. Eng. Perform. PD NOV PY 2012 VL 21 IS 11 BP 2207 EP 2217 DI 10.1007/s11665-011-0118-7 PG 11 WC Materials Science, Multidisciplinary SC Materials Science GA 024CR UT WOS:000310085800001 ER PT J AU Klein, K Aarons, L ter Kuile, FO Nosten, F White, NJ Edstein, MD Teja-Isavadharm, P AF Klein, Kerenaftali Aarons, Leon ter Kuile, Feiko O. Nosten, Francois White, Nick J. Edstein, Michael D. Teja-Isavadharm, Paktiya TI Population pharmacokinetics of halofantrine in healthy volunteers and patients with symptomatic falciparum malaria SO JOURNAL OF PHARMACY AND PHARMACOLOGY LA English DT Article DE Bayesian modelling; halofantrine; malaria; non-linear mixed effects modelling; population pharmacokinetics ID PLASMODIUM-FALCIPARUM; MEFLOQUINE; DESBUTYLHALOFANTRINE; CARDIOTOXICITY; RESISTANCE; REGIMEN AB Aims To investigate the population pharmacokinetics of the antimalarial halofantrine (HF) in healthy volunteers and patients with symptomatic falciparum malaria. Methods Healthy volunteer data were obtained from six volunteers who received three different doses of HF (250, 500 and 1000 mg) after an overnight fast with a washout period of at least 6 weeks between doses. Patient data (n = 188) were obtained from randomised controlled trials conducted on the ThaiBurmese border in the early 1990s. They were either assigned to receive a total HF dose of 24 mg/kg (8 mg/kg every 6 h for 24 h) or 72 mg/kg (8 mg/kg every 6 to 10 h for 3 days). The population pharmacokinetics of HF were evaluated using non-linear mixed effects modelling with a two-compartment model with first-order absorption. Key findings The population estimates of apparent clearance (CL), volume of compartment one (V1), distributional clearance (CLD) and volume of compartment two (V2) of HF in healthy volunteers were 2453 l/day (102 l/h), 2386 l, 716 l/day (29.8 l/h) and 2641 l, respectively. The population estimates of the PK parameters in patients were 429 l/day (17.9 l/h), 729 l, 178 l/day (7.42 l/h) and 1351 l, respectively. All PK parameters were significantly related to body weight and some were related to sex, sampling method, pre-treatment parasite density and whether patients vomited or not. When the two datasets were analysed jointly using a maximum likelihood method, the population estimates in patients were 196 l/day (8.17 l/h), 161 l, 65 l/day (2.71 l/h) and 89 l, respectively, and the parameters were significantly related to body weight and sex. Bayesian analysis of the patient data, with a diffuse prior based on the healthy volunteer data analysis results, yielded the population estimates 354 l/day (14.8 l/h), 728 l, 162 l/day (6.75 l/h) and 1939 l, respectively. Conclusions The pharmacokinetic properties of HF in patients with malaria are affected by several demographic variables as well as other relevant covariates. Apparent differences between the healthy volunteer and the patient data analysis results are not entirely due to differences in bioavailability. For the patient data analysis, the Bayesian method was preferred, as the fitting procedure was more stable, allowing random effects to be estimated for all four dispositional parameters. C1 [Aarons, Leon] Univ Manchester, Sch Pharm & Pharmaceut Sci, Manchester M13 9PT, Lancs, England. [Klein, Kerenaftali] Univ Queensland, Queensland Clin Trials & Biostat Ctr, Sch Populat Hlth, Brisbane, Qld, Australia. [ter Kuile, Feiko O.; Nosten, Francois] Shoklo Malaria Res Unit, Tak, Thailand. [ter Kuile, Feiko O.] Univ Liverpool, Liverpool Sch Trop Med, Child & Reprod Hlth Grp, Liverpool L3 5QA, Merseyside, England. [ter Kuile, Feiko O.] Univ Amsterdam, Acad Med Ctr, Dept Infect Dis Trop Med & AIDS, NL-1105 AZ Amsterdam, Netherlands. [Nosten, Francois; White, Nick J.] Mahidol Univ, Fac Trop Med, Bangkok, Thailand. [Nosten, Francois; White, Nick J.] Churchill Hosp, Ctr Clin Vaccinol & Trop Med, Oxford OX3 7LJ, England. [Edstein, Michael D.] Australian Army Malaria Inst, Enoggera, Qld, Australia. [Teja-Isavadharm, Paktiya] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. RP Aarons, L (reprint author), Univ Manchester, Sch Pharm & Pharmaceut Sci, Manchester M13 9PT, Lancs, England. EM leon.aarons@manchester.ac.uk OI Nosten, Francois/0000-0002-7951-0745; ter Kuile, Feiko/0000-0003-3663-5617 FU Overseas Research Students Awards Scheme; Pfizer Central Research FX K. Klein was supported by the Overseas Research Students Awards Scheme and Pfizer Central Research. The healthy volunteer data were provided by Geoffrey Edwards from The University of Liverpool. The opinions expressed herein are those of the authors and do not necessarily reflect those of the Australian Defence Force, Joint Health Command or any extant policy. NR 30 TC 1 Z9 1 U1 0 U2 5 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0022-3573 J9 J PHARM PHARMACOL JI J. Pharm. Pharmacol. PD NOV PY 2012 VL 64 IS 11 BP 1603 EP 1613 DI 10.1111/j.2042-7158.2012.01554.x PG 11 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA 021WA UT WOS:000309914900007 PM 23058047 ER PT J AU Bressette, JW Beck, H Beauchamp, VB AF Bressette, James W. Beck, Harald Beauchamp, Vanessa B. TI Beyond the browse line: complex cascade effects mediated by white-tailed deer SO OIKOS LA English DT Article ID MYCORRHIZAL INFECTION; TROPICAL FOREST; BOTTOM-UP; TOP-DOWN; POPULATIONS; COMMUNITY; ABUNDANCE; DECOMPOSITION; MANIPULATION; DISTURBANCE AB In many ecosystems, browsing of large mammals can affect plant species compositions. However, much less is known about potential above- and below-ground trophic interactions of large browsing mammals. This study focused on the direct and indirect effects of browsing on trophic and abiotic interactions within forest ecosystems. To quantify above- and below-ground cascade effects, white-tailed deer have been excluded for over 18 years from three 4-ha plots, which were paired with same sized deer access plots. Our results demonstrate complex direct and indirect cascade effects on forest food webs. Deer exclusion directly altered woody species composition and significantly increased shrub and sapling density. Above-ground cascade effects include greater leaf litter accumulation and higher arthropod density and biomass within the exclosures. Below-ground indirect effects include significant decrease in soil nutrients, and higher arbuscular mycorrhizal fungal inoculum potential in the exclosures. Because ecosystems have finite resource availability, high deer density may imbalance the system by redirecting resources toward maintaining deer biomass at the expense of multiple trophic levels throughout the forest community. Both complex bottom up and top down trophic cascade effects demonstrated largely unidirectional negative responses suggesting that high deer density has reduced the biodiversity of the forest community. C1 [Bressette, James W.; Beck, Harald; Beauchamp, Vanessa B.] Towson Univ, Dept Biol Sci, Towson, MD 21252 USA. RP Bressette, JW (reprint author), USA, Environm Hlth Risk Assessment Program, Inst Publ Hlth, 5158 Blackhawk Rd,E-1675, Aberdeen Proving Ground, MD 21010 USA. EM bressette-3@verizon.net FU Towson Univ. Dept of Biological Sciences; Fisher College of Science and Mathematics; Explorers Club Washington Group FX We thank J. LaPolla, and M. McDonald for their help. W. McShea kindly permitted access to the deer exclosures. Thanks to our undergraduate and graduate students D. Borowy, A. Busey, D. Ellis, T. Meyers, M. Volk and R. Zeroth, for their tireless assistance in the field and lab. Funding was provided by Towson Univ. Dept of Biological Sciences, Fisher College of Science and Mathematics, and The Explorers Club Washington Group. NR 47 TC 26 Z9 26 U1 9 U2 111 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0030-1299 J9 OIKOS JI Oikos PD NOV PY 2012 VL 121 IS 11 BP 1749 EP 1760 DI 10.1111/j.1600-0706.2011.20305.x PG 12 WC Ecology SC Environmental Sciences & Ecology GA 023WB UT WOS:000310066600004 ER PT J AU Bakhtyar, R Barry, DA Kees, CE AF Bakhtyar, R. Barry, D. A. Kees, C. E. TI Numerical experiments on breaking waves on contrasting beaches using a two-phase flow approach SO ADVANCES IN WATER RESOURCES LA English DT Article DE Beach morphology; Nearshore hydrodynamics; Sediment transport; Spilling and plunging breakers; Multi-phase flow; Turbulent energy ID SUSPENDED-SEDIMENT TRANSPORT; SHEET FLOW; SWASH ZONE; SURF ZONE; TURBULENCE; MODEL; SIMULATION; HYDRODYNAMICS; PARTICLES; NEARSHORE AB A mechanistic understanding of beach environments needs to account for interactions of oceanic forcing and beach materials, in particular the role of waves on the evolution of the beach profile. A fully coupled two-phase flow model was used to simulate nearshore fluid-sediment turbulent flow in the cross-shore direction. It includes the Reynolds-Averaged Navier-Stokes equations and turbulent stress closures for each phase, and accounts for inter-granular stresses. The model has previously been validated using laboratory-scale data, so the results are likely more reliable for that scale. It was used to simulate wave breaking and the ensuing hydrodynamics and sediment transport processes in the surf/swash zones. Numerical experiments were conducted to investigate the effects of varying beach and wave characteristics (e. g., beach slope, sediment grain size, wave periods and heights) on the foreshore profile changes. Spilling and plunging breakers occur on dissipative and intermediate beaches, respectively. The impact of these wave/beach types on nearshore zone hydrodynamics and beach morphology was determined. The numerical results showed that turbulent kinetic energy, sediment concentrations and transport rate are greater on intermediate than on dissipative beaches. The results confirmed that wave energy, beach grain size and bed slope are main factors for sediment transport and beach morphodynamics. The location of the maximum sediment transport is near the breaking point for both beach types. Coarse-and fine-sand beaches differ significantly in their erosive characteristics (e. g., foreshore profile evolutions are erosive and accretionary on the fine and coarse sand beaches, respectively). In addition, a new parameter (based on main driving factors) is proposed that can characterize the sediment transport in the surf and swash zones. The results are consistent with existing physical observations, suggesting that the two-phase flow model is suitable for the simulation of hyper-concentrated mixed water-sediment flows in the nearshore. The model thus has potential as a useful tool for investigating interactions between nearshore hydrodynamics and beach morphology. (C) 2012 Elsevier Ltd. All rights reserved. C1 [Bakhtyar, R.; Barry, D. A.] Ecole Polytech Fed Lausanne, Lab Technol Ecol, Inst Ingn Environm, Fac Environm Nat Architectural & Construit ENAC,S, CH-1015 Lausanne, Switzerland. [Kees, C. E.] USA, Coastal & Hydraul Lab, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Bakhtyar, R (reprint author), Ecole Polytech Fed Lausanne, Lab Technol Ecol, Inst Ingn Environm, Fac Environm Nat Architectural & Construit ENAC,S, CH-1015 Lausanne, Switzerland. EM roham.bakhtyar@epfl.ch; andrew.barry@epfl.ch; chris.kees@us.army.mil RI Bakhtyar, Roham/E-5787-2012; Barry, David/C-6077-2008 OI Barry, David/0000-0002-8621-0425 FU Swiss National Foundation [SNF 200021-135322]; Internal Research Investment Program of the Coastal and Hydraulics Laboratory FX Support of the Swiss National Foundation(SNF 200021-135322) is acknowledged. This manuscript is the extension of authors' paper that was presented at THESIS-2011 conference. Kees acknowledges support from the Internal Research Investment Program of the Coastal and Hydraulics Laboratory. Permission was granted by the Chief of Engineers to publish this information. NR 48 TC 5 Z9 5 U1 3 U2 18 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0309-1708 J9 ADV WATER RESOUR JI Adv. Water Resour. PD NOV PY 2012 VL 48 BP 68 EP 78 DI 10.1016/j.advwatres.2012.03.025 PG 11 WC Water Resources SC Water Resources GA 017FN UT WOS:000309575600007 ER PT J AU Chen, HP Zhu, SH Casabon, I Hallam, SJ Crocker, FH Mohn, WW Indest, KJ Eltis, LD AF Chen, Hao-Ping Zhu, Song-Hua Casabon, Israel Hallam, Steven J. Crocker, Fiona H. Mohn, William W. Indest, Karl J. Eltis, Lindsay D. TI Genomic and Transcriptomic Studies of an RDX (Hexahydro-1,3,5-Trinitro-1,3,5-Triazine)-Degrading Actinobacterium SO APPLIED AND ENVIRONMENTAL MICROBIOLOGY LA English DT Article ID GENE-CLUSTER; GORDONIA; HEXAHYDRO-1,3,5-TRINITRO-1,3,5-TRIAZINE; DEGRADATION; SEQUENCE; INSIGHTS; ACTINOMYCETE; BIOLOGY; SP. AB Whole-genome sequencing, transcriptomic analyses, and metabolic reconstruction were used to investigate Gordonia sp. strain KTR9's ability to catabolize a range of compounds, including explosives and steroids. Aspects of this mycolic acid-containing actinobacterium's catabolic potential were experimentally verified and compared with those of rhodococci and mycobacteria. C1 [Crocker, Fiona H.; Indest, Karl J.] USA, Engn Res & Dev Ctr, Environm Lab, Vicksburg, MS USA. [Chen, Hao-Ping; Zhu, Song-Hua; Casabon, Israel; Hallam, Steven J.; Mohn, William W.; Eltis, Lindsay D.] Univ British Columbia, Dept Microbiol & Immunol, Inst Life Sci, Vancouver, BC V5Z 1M9, Canada. RP Indest, KJ (reprint author), USA, Engn Res & Dev Ctr, Environm Lab, Vicksburg, MS USA. EM Karl.J.Indest@usace.army.mil; leltis@mail.ubc.ca RI Eltis, Lindsay/J-8272-2015 OI Eltis, Lindsay/0000-0002-6774-8158 FU U.S. Army Corps of Engineers Environmental Quality Research Program [08-34]; Strategic Environmental Research and Development Program [ER-1609]; Genome BC; Fonds de Recherche en Sante du Quebec; Michael Smith Foundation for Health Research FX This research was funded in part through grants from the U.S. Army Corps of Engineers Environmental Quality Research Program (project 08-34, K.J.I.), the Strategic Environmental Research and Development Program (project ER-1609, F. H. C.), and Genome BC (L. D. E., S.J.H., and W. W. M.). I. C. is the recipient of a postdoctoral fellowship from the Fonds de Recherche en Sante du Quebec and the Michael Smith Foundation for Health Research. NR 21 TC 11 Z9 12 U1 0 U2 8 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0099-2240 J9 APPL ENVIRON MICROB JI Appl. Environ. Microbiol. PD NOV PY 2012 VL 78 IS 21 BP 7798 EP 7800 DI 10.1128/AEM.02120-12 PG 3 WC Biotechnology & Applied Microbiology; Microbiology SC Biotechnology & Applied Microbiology; Microbiology GA 018RB UT WOS:000309678600035 PM 22923396 ER PT J AU Garner, LE Thomas, AW Sumner, JJ Harvey, SP Bazan, GC AF Garner, Logan E. Thomas, Alexander W. Sumner, James J. Harvey, Steven P. Bazan, Guillermo C. TI Conjugated oligoelectrolytes increase current response and organic contaminant removal in wastewater microbial fuel cells SO ENERGY & ENVIRONMENTAL SCIENCE LA English DT Article ID 2-PHOTON ABSORPTION; AIR-CATHODE; ELECTRICITY; AGGREGATION; GENERATION; OLIGOMERS; CHROMOPHORES; LAYERS AB The conjugated oligoelectrolyte 4,4'-bis(4'-(N,N-bis(6 ''-(N,N,N-trimethylammonium)hexyl)amino)-styryl)stilbene tetraiodide (DSSN+) has been employed to improve the performance of wastewater microbial fuel cells (MFCs) with respect to current generation and organic contaminant removal. The best performance was afforded by biocathode type MFCs run in the presence of DSSN+. Laser scanning confocal microscopy confirmed cellular uptake of DSSN+ in the biofilms. C1 [Garner, Logan E.; Thomas, Alexander W.; Bazan, Guillermo C.] Univ Calif Santa Barbara, Dept Mat, Ctr Polymers & Organ Solids, Dept Chem & Biochem, Santa Barbara, CA 93106 USA. [Sumner, James J.] USA, Res Lab, Sensors & Elect Devices Directorate, Adelphi, MD 20783 USA. [Harvey, Steven P.] USA, Edgewater Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. RP Garner, LE (reprint author), Univ Calif Santa Barbara, Dept Mat, Ctr Polymers & Organ Solids, Dept Chem & Biochem, Santa Barbara, CA 93106 USA. EM james.j.sumner4.civ@mail.mil; steve.harvey@us.army.mil; bazan@chem.ucsb.edu RI Bazan, Guillermo/B-7625-2014 FU Institute for Collaborative Biotechnologies [W911NF-09-D-0001]; Air Force Office of Scientific Research [FA9550-08-1-0248]; National Center for Research Resources Shared Instrument Grant [1S10RR017753-01]; National Science Foundation [DMR05-20415] FX The authors thank the Institute for Collaborative Biotechnologies (W911NF-09-D-0001), and the Air Force Office of Scientific Research (FA9550-08-1-0248) for financial support; the National Center for Research Resources Shared Instrument Grant (1S10RR017753-01) for funding of confocal microscopy facilities employed in this work; the National Science Foundation (DMR05-20415) for support of Materials Research Laboratory (MRL) central facilities that house the SEM instrument employed in this work; Mr Mark Cornish for assistance in SEM imaging; and Dr Christian J. Sund and Dr Amethist S. Finch for technical assistance and consultation in the operation of wastewater MFCs. NR 28 TC 24 Z9 24 U1 3 U2 49 PU ROYAL SOC CHEMISTRY PI CAMBRIDGE PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND SN 1754-5692 J9 ENERG ENVIRON SCI JI Energy Environ. Sci. PD NOV PY 2012 VL 5 IS 11 BP 9449 EP 9452 DI 10.1039/c2ee22839d PG 4 WC Chemistry, Multidisciplinary; Energy & Fuels; Engineering, Chemical; Environmental Sciences SC Chemistry; Energy & Fuels; Engineering; Environmental Sciences & Ecology GA 023AV UT WOS:000310006200023 ER PT J AU Bonsignori, M Pollara, J Moody, MA Alpert, MD Chen, X Hwang, KK Gilbert, PB Huang, Y Gurley, TC Kozink, DM Marshall, DJ Whitesides, JF Tsao, CY Kaewkungwal, J Nitayaphan, S Pitisuttithum, P Rerks-Ngarm, S Kim, JH Michael, NL Tomaras, GD Montefiori, DC Lewis, GK DeVico, A Evans, DT Ferrari, G Liao, HX Haynes, BF AF Bonsignori, Mattia Pollara, Justin Moody, M. Anthony Alpert, Michael D. Chen, Xi Hwang, Kwan-Ki Gilbert, Peter B. Huang, Ying Gurley, Thaddeus C. Kozink, Daniel M. Marshall, Dawn J. Whitesides, John F. Tsao, Chun-Yen Kaewkungwal, Jaranit Nitayaphan, Sorachai Pitisuttithum, Punnee Rerks-Ngarm, Supachai Kim, Jerome H. Michael, Nelson L. Tomaras, Georgia D. Montefiori, David C. Lewis, George K. DeVico, Anthony Evans, David T. Ferrari, Guido Liao, Hua-Xin Haynes, Barton F. TI Antibody-Dependent Cellular Cytotoxicity-Mediating Antibodies from an HIV-1 Vaccine Efficacy Trial Target Multiple Epitopes and Preferentially Use the VH1 Gene Family SO JOURNAL OF VIROLOGY LA English DT Article ID IMMUNODEFICIENCY-VIRUS TYPE-1; HUMAN MONOCLONAL-ANTIBODIES; NEUTRALIZING-ANTIBODY; RECEPTOR-BINDING; INFLUENZA-VIRUS; SHIV CHALLENGE; RHESUS-MONKEYS; GP120; RESPONSES; ADCC AB The ALVAC-HIV/AIDSVAX-B/E RV144 vaccine trial showed an estimated efficacy of 31%. RV144 secondary immune correlate analysis demonstrated that the combination of low plasma anti-HIV-1 Env IgA antibodies and high levels of antibody-dependent cellular cytotoxicity (ADCC) inversely correlate with infection risk. One hypothesis is that the observed protection in RV144 is partially due to ADCC-mediating antibodies. We found that the majority (73 to 90%) of a representative group of vaccinees displayed plasma ADCC activity, usually (96.2%) blocked by competition with the C1 region-specific A32 Fab fragment. Using memory B-cell cultures and antigen-specific B-cell sorting, we isolated 23 ADCC-mediating nonclonally related antibodies from 6 vaccine recipients. These antibodies targeted A32-blockable conformational epitopes (n = 19), a non-A32-blockable conformational epitope (n = 1), and the gp120 Env variable loops (n = 3). Fourteen antibodies mediated cross-clade target cell killing. ADCC-mediating antibodies displayed modest levels of V-heavy (VH) chain somatic mutation (0.5 to 1.5%) and also displayed a disproportionate usage of VH1 family genes (74%), a phenomenon recently described for CD4-binding site broadly neutralizing antibodies (bNAbs). Maximal ADCC activity of VH1 antibodies correlated with mutation frequency. The poly-clonality and low mutation frequency of these VH1 antibodies reveal fundamental differences in the regulation and maturation of these ADCC-mediating responses compared to VH1 bNAbs. C1 [Bonsignori, Mattia; Pollara, Justin; Moody, M. Anthony; Chen, Xi; Hwang, Kwan-Ki; Gurley, Thaddeus C.; Kozink, Daniel M.; Marshall, Dawn J.; Whitesides, John F.; Tsao, Chun-Yen; Tomaras, Georgia D.; Montefiori, David C.; Ferrari, Guido; Liao, Hua-Xin; Haynes, Barton F.] Duke Univ, Med Ctr, Durham, NC 27706 USA. [Alpert, Michael D.; Evans, David T.] Harvard Univ, Sch Med, Boston, MA USA. [Gilbert, Peter B.; Huang, Ying] Fred Hutchinson Canc Res Ctr, Stat Ctr HIV AIDS Res & Prevent, Seattle, WA 98104 USA. [Kaewkungwal, Jaranit; Pitisuttithum, Punnee] Mahidol Univ, Bangkok 10700, Thailand. [Nitayaphan, Sorachai] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Rerks-Ngarm, Supachai] Minist Publ Hlth, Dept Dis Control, Nonthaburi, Thailand. [Kim, Jerome H.; Michael, Nelson L.] US Mil HIV Res Program, Rockville, MD USA. [Lewis, George K.; DeVico, Anthony] Univ Maryland, Sch Med, Inst Human Virol, Baltimore, MD 21201 USA. RP Bonsignori, M (reprint author), Duke Univ, Med Ctr, Durham, NC 27706 USA. EM mattia.bonsignori@duke.edu RI Ferrari, Guido/A-6088-2015; Tomaras, Georgia/J-5041-2016 FU National Institutes of Health (NIH), National Institutes of Allergies and Infectious Diseases (NIAID) [AI07392]; Division of AIDS with the Center for HIV/AIDS Vaccine Immunology (CHAVI) [U19 AI067854]; Collaboration for AIDS Vaccine Discovery (CAVD) from the Bill and Melinda Gates Foundation [38619, 38650]; U.S. Army Medical Research and Materiel Command (USAMRMC) [Y1-AI-2642-12]; NIAID [Y1-AI-2642-12]; Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. [W81XWH-07-2-0067]; U.S. Department of Defense [W81XWH-07-2-0067] FX This work was supported by the National Institutes of Health (NIH), National Institutes of Allergies and Infectious Diseases (NIAID), the Division of AIDS with the Center for HIV/AIDS Vaccine Immunology (CHAVI) (grant U19 AI067854); by a Collaboration for AIDS Vaccine Discovery (CAVD) grant to B. F. H. from the Bill and Melinda Gates Foundation; in part by Interagency Agreement Y1-AI-2642-12 between U.S. Army Medical Research and Materiel Command (USAMRMC) and the NIAID. In addition, this work was supported by a cooperative agreement (W81XWH-07-2-0067) between the Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., and the U.S. Department of Defense. Additional support was provided by the CAVD from the Bill and Melinda Gates Foundation (grants 38619 to G. F. and D. C. M. and 38650 to G. F.). J.P. was supported by the NIH, NIAID grant AI07392. NR 54 TC 154 Z9 155 U1 0 U2 13 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0022-538X J9 J VIROL JI J. Virol. PD NOV PY 2012 VL 86 IS 21 BP 11521 EP 11532 DI 10.1128/JVI.01023-12 PG 12 WC Virology SC Virology GA 018JT UT WOS:000309657100011 PM 22896626 ER PT J AU Hang, J Clifford, RJ Yang, Y Riley, MC Mody, RM Kuschner, RA Lesho, EP AF Hang, Jun Clifford, Robert J. Yang, Yu Riley, Matthew C. Mody, Rupal M. Kuschner, Robert A. Lesho, Emil P. TI Genome Sequencing of Pathogenic Rhodococcus spp. SO EMERGING INFECTIOUS DISEASES LA English DT Letter ID INFECTION; ERYTHROPOLIS C1 [Hang, Jun; Clifford, Robert J.; Yang, Yu; Riley, Matthew C.; Kuschner, Robert A.; Lesho, Emil P.] Walter Reed Army Inst Res, Silver Spring, MD 20902 USA. [Mody, Rupal M.] William Beaumont Army Med Ctr, El Paso, TX 79920 USA. RP Lesho, EP (reprint author), Walter Reed Army Inst Res, 503 Robert Grant Ave, Silver Spring, MD 20902 USA. EM carolinelesho@yahoo.com NR 9 TC 3 Z9 3 U1 2 U2 5 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 1080-6040 EI 1080-6059 J9 EMERG INFECT DIS JI Emerg. Infect. Dis PD NOV PY 2012 VL 18 IS 11 BP 1915 EP 1916 DI 10.3201/eid1811.120818 PG 2 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 268LQ UT WOS:000328172600037 PM 23092600 ER PT J AU Eliasson, A Kashani, M Dela Cruz, G Vernalis, M AF Eliasson, Arn Kashani, Mariam Dela Cruz, Georgia Vernalis, Marina TI Readiness and Associated Health Behaviors and Symptoms in Recently Deployed Army National Guard Solders SO MILITARY MEDICINE LA English DT Article AB To examine major factors affecting readiness in the Army National Guard (ARNG), 265 soldiers of the Pennsylvania ARNG redeploying in 2010 from Iraq and Afghanistan were evaluated with validated questionnaires during their first unit formation. The questionnaires assessed demographic information, health habits, levels of perceived stress, mood, diet, sleep, and exercise habits, and included a screening question for depression. Our analysis revealed no negative effects of multiple deployments in this cohort of ARNG soldiers. There was no apparent impact on readiness attributable to soldiers' living locations; there did not appear to be an urban rural divide. There were, however, numerous opportunities to improve health behaviors, including smoking (prevalence of 41%), poor dietary choices and sleep habits, as well as management of stress and mood disorders. A striking prevalence of sleep apnea exists in these ARNG soldiers (40%), approximately double that previously measured in the general U.S. population. Soldiers with high stress, depression, poor sleep quality, and sleep apnea are at increased long-term risk for cardiovascular complications and deserve focused interventions to encourage lifestyle behavior change. C1 [Eliasson, Arn; Kashani, Mariam; Vernalis, Marina] Walter Reed Army Med Ctr, Integrat Cardiac Hlth Project, Washington, DC 20307 USA. [Dela Cruz, Georgia] US Army, Off Surg Gen Dent Affairs, Falls Church, VA USA. RP Eliasson, A (reprint author), Walter Reed Army Med Ctr, Integrat Cardiac Hlth Project, 6900 Georgia Ave, Washington, DC 20307 USA. FU Telemedicine and Advanced Technology Research Center; U.S. Army Medical Research and Materiel Command FX This research was performed as Approved Proposal #08016001, funded by the Telemedicine and Advanced Technology Research Center, U.S. Army Medical Research and Materiel Command, 504 Scott Street, Fort Detrick, MD 21702-5012. NR 39 TC 3 Z9 3 U1 1 U2 7 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD NOV PY 2012 VL 177 IS 11 BP 1254 EP 1260 DI 10.7205/MILMED-D-11-00242 PG 7 WC Medicine, General & Internal SC General & Internal Medicine GA V33OF UT WOS:000209027400004 PM 23198498 ER PT J AU Lawrence, KL Benante, JP Close, NC AF Lawrence, Kendra L. Benante, John Paul Close, Nicole C. TI Field-User Acceptability Evaluation of a New Stick Camouflage Face Paint Formulation With and Without the Insect Repellent DEET SO MILITARY MEDICINE LA English DT Article AB Two newly designed formulations of stick camouflage face paint, one with 30% N,N-diethy1-3-methylbenzamide (DEET) and the other without DEBT, were evaluated for acceptability among soldiers upon completion of normal military field training exercises. A total of 156 soldiers participated and completed a self-administered survey answering questions about product acceptability, packaging, and ease of use. Results of the study indicated that soldiers found stick formulations, with and without DEBT, to be acceptable for use (62.9% and 83.7%, respectively). This data will be used by the Program Management Office at the U.S. Army Medical Materiel Development Activity to support a request to the Armed Forces Pest Management Board to assign a National Stock Number. C1 [Lawrence, Kendra L.] US Army Med Mat Dev Act GDIT, Pharmaceut Syst Project Management Off, Ft Detrick, MD 21702 USA. [Benante, John Paul] Walter Reed Army Inst Res, Entomol Branch, Silver Spring, MD 20910 USA. [Close, Nicole C.] Empiristat Inc, Mt Airy, MD 21771 USA. RP Lawrence, KL (reprint author), US Army Med Mat Dev Act GDIT, Pharmaceut Syst Project Management Off, 1430 Vet Dr, Ft Detrick, MD 21702 USA. FU U.S. Army Medical Materiel Development Activity FX We thank Harold Howe, U.S. Army Medical Department Board, and David Dellenbaugh, U.S. Army Natick Soldier Center, for facilitating coordination of volunteers at Camp Bulls and Fort Benning, respectively. Funding for this study was provided by the U.S. Army Medical Materiel Development Activity. NR 9 TC 0 Z9 0 U1 0 U2 3 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD NOV PY 2012 VL 177 IS 11 BP 1322 EP 1327 DI 10.7205/MELMED-D-12-00204 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA V33OF UT WOS:000209027400014 PM 23198508 ER PT J AU Brett-Major, DM Hakre, S Naito, NA Armstrong, A Bower, EA Michael, NL Scott, PT AF Brett-Major, David M. Hakre, Shilpa Naito, Neal A. Armstrong, Adam Bower, Eric A. Michael, Nelson L. Scott, Paul T. TI Epidemiology of Contemporary Seroincident HIV Infection in the Navy and Marine Corps SO MILITARY MEDICINE LA English DT Article AB Human Immunodeficiency Virus (HIV) infection continues at a steady rate among U.S. Sailors and Marines. This study provides the first service-specific description of HIV infection demographics. All Sailors and Marines identified as HIV infected between January 2005 and August 2010 were included. The project compared personnel and epidemiologic data, and tested reposed sera in the Department of Defense Serum Repository. This group comprised 410 Sailors and 86 Marines, predominantly men. HIV infected Marines were more likely to be foreign born than their Navy counterparts, 42% versus 10%, p < 0.001. Approximately half of the patients had deployed including to the wars in Iraq or Afghanistan. Nearly half of each group was infected by the age of 25. Similar to the U.S. epidemic, Black race was over-represented. Unlike national rates, Hispanic Sailors and Marines were not over-represented. Demographics were distinct for those of specific occupational specialties. Certain ship classes carried lower incidences. Clustering of HIV infection risk occurred around deployment. The Navy and Marine Corps have different patterns of HIV infection, which may merit distinct approaches to prevention. The Navy may have unique targets for prevention efforts to include pipeline training and first assignment as well as particular occupational environments. C1 [Brett-Major, David M.] US Mil Trop Med, Navy Med Profess Dev Ctr, Bethesda, MD 20889 USA. [Brett-Major, David M.] Uniformed Serv Univ Hlth Sci, Dept Prevent Med & Biometr, Bethesda, MD 20814 USA. [Hakre, Shilpa; Michael, Nelson L.; Scott, Paul T.] Walter Reed Army Inst Res, US Mil HIV Res Program, Bethesda, MD 20817 USA. [Naito, Neal A.] US Navy, Bur Med & Surg, Falls Church, VA 22042 USA. [Armstrong, Adam] Navy Bloodborne Infect Management Ctr, Navy Marine Corps Publ Hlth Ctr, Bethesda, MD 20889 USA. [Bower, Eric A.] Navy Personnel Command Pers 82, Millington, TN 38055 USA. RP Brett-Major, DM (reprint author), US Mil Trop Med, Navy Med Profess Dev Ctr, 8901 Wisconsin Ave, Bethesda, MD 20889 USA. FU U.S. Navy Bureau of Medicine and Surgery; Military Infectious Diseases Research Program [MIDRP-H014010OTPPOC] FX This project is a public health activity reviewed and exempted under the Walter Reed Army Institute of Research (WRAIR) Institutional Review Board, serial RV314. Ms. Jacqueline Sheffield, Deputy Head, NBIMC, and her team were critical to all phases of project planning and execution. This activity received essential data support from Gunnery Sergeants Kenneth Emery and Jeremiah Johnson, Headquarters U.S. Marine Corps, and Joyce Comelius and Jenny Cuccia at the Navy Personnel Command. Mark Milazzo coordinated data pooling and management for privacy and security. Fang Li managed all data for analysis. Dr. Christopher Rennix and Michelle Barnes, Epidemiology Data Center, Navy Marine Corps Public Health Center, provided significant medical data support. This project was funded in part by the U.S. Navy Bureau of Medicine and Surgery and the Military Infectious Diseases Research Program, project MIDRP-H014010OTPPOC. NR 18 TC 5 Z9 5 U1 1 U2 1 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD NOV PY 2012 VL 177 IS 11 BP 1328 EP 1334 DI 10.7205/MILMED-D-12-00299 PG 7 WC Medicine, General & Internal SC General & Internal Medicine GA V33OF UT WOS:000209027400015 PM 23198509 ER PT J AU Ernat, J Knox, J Orchowski, J Owens, B AF Ernat, Justin Knox, Jeffrey Orchowski, Joseph Owens, Brett TI Incidence and Risk Factors for Acute Low Back Pain in Active Duty Infantry SO MILITARY MEDICINE LA English DT Article AB Although much research has been performed on occupational risk factors for low back pain, little has been published on low back pain among infantrymen. This purpose of this study is to evaluate the incidence of acute low back pain amongst active duty infantrymen as compared to a matched control population. The Defense Medical Epidemiology Database was searched and incidence rates were calculated and compared between infantry and noninfantry soldiers. Data was stratified and controlled for age, race, marital status, rank, and branch of service using the Poisson multivariate regression analysis. Significantly lower rates of acute low back pain were discovered in active duty infantrymen when compared to matched controls (32.9 versus 49.5 cases per 1,000 person-years). Additionally, significantly lower rates were identified in the Marines versus the Army, and among junior enlisted compared to senior enlisted service members. C1 [Ernat, Justin; Knox, Jeffrey; Orchowski, Joseph; Owens, Brett] Tripler Army Med Ctr, Dept Orthoped Surg, Honolulu, HI 96859 USA. RP Ernat, J (reprint author), Tripler Army Med Ctr, Dept Orthoped Surg, 1 Jarrett White Rd, Honolulu, HI 96859 USA. NR 41 TC 6 Z9 6 U1 1 U2 1 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD NOV PY 2012 VL 177 IS 11 BP 1348 EP 1351 DI 10.7205/MILMED-D-12-00183 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA V33OF UT WOS:000209027400018 PM 23198512 ER PT J AU Causey, MW Burgess, PL Porta, CR Johnson, EK Steele, SR AF Causey, Marlin Wayne Burgess, Pamela L. Porta, Christopher Rees Johnson, Eric K. Steele, Scott R. TI Initial Operative Time and Metastatic Disease Recurrence SO MILITARY MEDICINE LA English DT Article AB Colon cancer metastases are a major source of morbidity and mortality for patients following oncologic resection. The purpose of this study was to identify whether operative time as a surrogate for resident involvement increased the risk of future liver metastases. We performed a retrospective review of patients undergoing curative colon resection from 2001 to 2010 at two military residency training hospitals. Intraoperative time as well as preoperative comorbidities and perioperative factors were gathered from electronic medical records. Liver metastases were identified from the tumor registry and inpatient records. A total of 106 patients underwent resection for colon cancer (Stage from 2001 to 2005 with 5-year follow-up through 2010. Operative times in patients who had recurrence was 205 60 minutes and those without recurrence was 187 73 minutes (p = 0.398). There was no correlation between operative time and time to recurrence (p = 0.452), and Cox regression demonstrated that case duration had no impact on time to metastatic recurrence (p = 0.461). Within our cohort, operative time had no impact on metastatic cancer recurrence. Surgeons should continue to focus on proper oncologic principles and tumor biology rather than the concern that increased operative time or resident training leads to increased metastatic recurrence. C1 [Causey, Marlin Wayne; Porta, Christopher Rees; Johnson, Eric K.; Steele, Scott R.] Madigan Army Med Ctr, Dept Surg, Tacoma, WA 98431 USA. [Burgess, Pamela L.] Eisenhower Army Med Ctr, Dept Surg, Ft Gordon, GA 30905 USA. RP Causey, MW (reprint author), Madigan Army Med Ctr, Dept Surg, 9040 Fitzsimmons Ave, Tacoma, WA 98431 USA. NR 28 TC 0 Z9 0 U1 0 U2 0 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD NOV PY 2012 VL 177 IS 11 BP 1382 EP 1386 DI 10.7205/MILMED-D-12-00053 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA V33OF UT WOS:000209027400023 PM 23198517 ER PT J AU Serra, MM Greenburg, D Barnwell, M Fallah, D Keith, K Mysliwiec, V AF Serra, Marc M. Greenburg, David Barnwell, Megan Fallah, David Keith, Karen Mysliwiec, Vincent TI Maxillomandibular Advancement as Surgical Treatment for Obstructive Sleep Apnea in Active Duty Military Personnel: A Retrospective Cohort SO MILITARY MEDICINE LA English DT Article AB Objective: The objective of our study is to assess the surgical outcomes of active duty military personnel undergoing maxillomandibular advancement (MMA) for the treatment of obstructive sleep apnea. Methods: Pre- and postoperative data on 37 military personnel who underwent MMA were assessed for changes in apnea-hypopnea index (AHI) and minimum oxygen saturation. A surgical success was defined as a reduction of by 50% or a postoperative AHI of 20. Results: 83.7% had an AHI greater than 20 (n = 33; range 7.6-118) with a mean preoperative AHI of 50.5 per hour. The postoperative AHI decreased by 36.3 to a new value of 14.2 (p <0.001). Most service members experienced a postoperative AHI of less than 20 (n = 28; 76%). Sixteen (43%) had a surgical cure (AHI < 5). The number of surgical successes for this study was 81% (n = 30). The mean minimal nocturnal oxyhemoglobin saturation did not significantly change from preoperative 85% (SD = 6.8%) to postoperative 86% (SD = 7%; p = 0.21). Conclusion: MMA represents a viable surgical treatment option for military personnel in whom continuous positive airway pressure is either not tolerated or for those who desire a fully deployable status. C1 [Serra, Marc M.; Keith, Karen] Joint Base Lewis McChord, Madigan Healthcare Syst, Oral & Maxillofacial Surg Dept, Tacoma, WA 98431 USA. [Greenburg, David] Joint Base Lewis McChord, Madigan Healthcare Syst, Internal Med, Tacoma, WA 98431 USA. [Barnwell, Megan] Brooke Army Med Ctr, Dept Cardiol, San Antonio, TX 78234 USA. [Fallah, David] William Beaumont Army Med Ctr, Oral & Maxillofacial Surg Dept, El Paso, TX 79920 USA. [Mysliwiec, Vincent] Joint Base Lewis McChord, Madigan Healthcare Syst, Pulmonol Crit Care Sleep Med, Tacoma, WA 98431 USA. RP Serra, MM (reprint author), Joint Base Lewis McChord, Madigan Healthcare Syst, Oral & Maxillofacial Surg Dept, 9040 Jackson Ave, Tacoma, WA 98431 USA. NR 33 TC 3 Z9 3 U1 0 U2 0 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD NOV PY 2012 VL 177 IS 11 BP 1387 EP 1392 DI 10.7205/MILMED-D-12-00172 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA V33OF UT WOS:000209027400024 PM 23198518 ER PT J AU Heitkamp, RA Peck, GW Kirkup, BC AF Heitkamp, Rae A. Peck, George W. Kirkup, Benjamin C. TI Maggot Debridement Therapy in Modern Army Medicine: Perceptions and Prevalence SO MILITARY MEDICINE LA English DT Article AB Maggot debridement therapy (MDT), despite its long history and safety profile, finds limited use in the military health care system. Although new methods are continually being investigated to debride wounds more quickly and effectively, MDT remains largely a therapy of last resort. We evaluated the frequency of MDT in the Army sector of the MHS and the decision-making process surrounding its use. A 22 question survey of Army physicians was prepared and distributed through select Medical Corps Consultants in specialties likely to practice debridement. 83% of respondents were familiar with MDT, and of those familiar, 63% were aware of FDA approval for the product and 10% had used the product themselves. The three most frequently cited reasons for not using the therapy were no need (52%), no access (23%), and insufficient experience (19%). Informing the 37% of physicians who are not aware of FDA approval is an obvious target for program improvement. However, as many do not find a need for MDT, targeted improvements to MDT access and education for those physicians who encounter indications for MDT would permit them to apply MDT where there is an unmet need. C1 [Heitkamp, Rae A.; Peck, George W.; Kirkup, Benjamin C.] Walter Reed Army Inst Res, Div Bacterial & Rickettsial Dis, Dept Wound Infect, Silver Spring, MD 20910 USA. RP Heitkamp, RA (reprint author), Walter Reed Army Inst Res, Div Bacterial & Rickettsial Dis, Dept Wound Infect, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. RI Kirkup, Benjamin/C-3610-2009 OI Kirkup, Benjamin/0000-0002-8722-6218 FU Defense Medical Research and Development Program (DMRDP) [D10_I_AR_J2_561] FX We gratefully acknowledge COL Duane Hospenthal and the other Medical Corps Consultants. Ms. Terrie Wheeler produced the online survey. COL Emil Lesho discussed the analysis of free-response data. Volunteers from WRAIR assisted in classifying free-response survey data. The Division of Entomology at WRAM. has graciously supported the biodebridement program. This research was funded by Defense Medical Research and Development Program (DMRDP) grant D10_I_AR_J2_561. NR 24 TC 3 Z9 3 U1 0 U2 12 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD NOV PY 2012 VL 177 IS 11 BP 1411 EP 1416 DI 10.7205/MILMED-D-12-00200 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA V33OF UT WOS:000209027400029 PM 23198524 ER PT J AU Lang, GT Harrigan, MJ AF Lang, Gregory T. Harrigan, Michael J. TI Changes in Hearing Thresholds as Measured by Decibels of Hearing Loss in British Army Air Corps Lynx and Apache Pilots SO MILITARY MEDICINE LA English DT Article AB Objective: Helicopter pilots are exposed to noise at work and are at risk of developing hearing loss in excess of that which naturally results from aging. We investigated whether Lynx pilots demonstrated changes to hearing thresholds that differed from Apache pilots. Methods: Survey responses were combined with audiometric data from a retrospective cohort of 59 Lynx and 87 Apache pilots. Subjects' audiograms were analyzed for air conduction thresholds with age correction performed in accordance with ISO 7029. Annual changes in low frequencies (0.5-2 kHz) and high frequencies (3-6 kHz) were calculated. Subjects were categorized for time in service and flying hours. Results: Hearing was better than predicted at nearly all frequencies in both ears for Lynx and Apache pilots. There were no differences in hearing between groups of pilots. Significant differences in hearing threshold changes existed for pilots with 20 or more years of service compared to those in other categories. Discussion: The results suggest that the circumaural earmuffs currently incorporated into the flying helmet mitigate the risk of noise-induced hearing loss in these pilots. C1 [Lang, Gregory T.] Eisenhower Army Med Ctr, Dept Family & Clin Med, Ft Gordon, GA 30905 USA. [Harrigan, Michael J.] Army Air Corps, Middle Wallop, Stockbridge, MA USA. RP Lang, GT (reprint author), Eisenhower Army Med Ctr, Dept Family & Clin Med, 300 Hosp Rd, Ft Gordon, GA 30905 USA. NR 17 TC 1 Z9 1 U1 0 U2 2 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD NOV PY 2012 VL 177 IS 11 BP 1431 EP 1437 DI 10.7205/MILMED-D-11-00409 PG 7 WC Medicine, General & Internal SC General & Internal Medicine GA V33OF UT WOS:000209027400032 PM 23198527 ER PT J AU DuBose, JJ Rajani, R Gilani, R Arthurs, ZA Morrison, JJ Clouse, WD Rasmussen, TE AF DuBose, Joseph J. Rajani, Ravi Gilani, Ramy Arthurs, Zachary A. Morrison, Jonathan J. Clouse, William D. Rasmussen, Todd E. TI Endovascular management of axillo-subclavian arterial injury: A review of published experience SO INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED LA English DT Review DE Calmodulin; Chlorpromazine; Leaf senescence; Salt stress; Sweet potato ID STENT-GRAFT PLACEMENT; ARTERIOVENOUS-FISTULA; TRAUMATIC INJURIES; BALLOON OCCLUSION; HEMORRHAGIC-SHOCK; BLUNT TRAUMA; REPAIR; PSEUDOANEURYSM; ANEURYSM; CANNULATION AB Background: The role of endovascular treatment for vascular trauma, including injury to the subclavian and axillary arteries, continues to evolve. Despite growing experience with the utilization of these techniques in the setting of artherosclerotic and aneurysmal disease, published reports in traumatic subclavian and axillary arterial injuries remain confined to sporadic case reports and case series. Methods: We conducted a review of the medical literature from 1990 to 2012 using Pubmed and OVID Medline databases to search for all reports documenting the use of endovascular stenting for the treatment of subclavian or axillary artery injuries. Thirty-two published reports were identified. Individual manuscripts were analysed to abstract data regarding mechanism, location and type of injury, endovascular technique and endograft type utilized, follow-up, and radiographic and clinical outcomes. Results: The use of endovascular stenting for the treatment of subclavian (150) or axillary (10) artery injuries was adequately described for only 160 patients from 1996 to the present. Endovascular treatment was employed after penetrating injury (56.3%; 29 GSW; 61 SW), blunt trauma (21.3%), iatrogenic catheter-related injury (21.8%) and surgical injury (0.6%). Injuries treated included pseudoaneurysm (77), AV fistula (27), occlusion (16), transection (8), perforation (22), dissection (6), or other injuries otherwise not fully described (4). Initial endovascular stent placement was successful in 96.9% of patients. Radiographic and clinical follow-up periods ranging from hospital discharge to 70 months revealed a follow-up patency of 84.4%. No mortalities related to endovascular intervention were reported. New neurologic deficits after the use of endovascular modalities were reported in only one patient. Conclusion: Endovascular treatment of traumatic subclavian and axillary artery injuries continues to evolve. Early results are promising, but experience with this modality and data on late follow-up remain limited. Additional multicenter prospective study and capture of data for these patients is warranted to further define the role of this treatment modality in the setting of trauma. Published by Elsevier Ltd. C1 [DuBose, Joseph J.] USAF, Univ Maryland, Med Syst, R Adams Cowley Shock Trauma Ctr,Baltimore Ctr Sus, Baltimore, MD 21201 USA. [Rajani, Ravi] Emory Univ, Sch Med, Dept Surg, Div Vasc Surg, Atlanta, GA 30322 USA. [Gilani, Ramy] Baylor Coll Med, Dept Surg, Div Vasc Surg & Endovasc Therapy Michael E DeBake, Houston, TX 77030 USA. [Arthurs, Zachary A.] San Antonio Mil Med Complex, Ft Sam Houston, TX USA. [Morrison, Jonathan J.; Rasmussen, Todd E.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP DuBose, JJ (reprint author), USAF, Univ Maryland, Med Syst, R Adams Cowley Shock Trauma Ctr,Baltimore Ctr Sus, 22 S Greene St,T5R46, Baltimore, MD 21201 USA. EM jjd3c@yahoo.com OI Morrison, Jonathan/0000-0001-7462-8456 NR 46 TC 25 Z9 30 U1 0 U2 1 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0020-1383 J9 INJURY JI Injury-Int. J. Care Inj. PD NOV PY 2012 VL 43 IS 11 BP 1785 EP 1792 DI 10.1016/j.injury.2012.08.028 PG 8 WC Critical Care Medicine; Emergency Medicine; Orthopedics; Surgery SC General & Internal Medicine; Emergency Medicine; Orthopedics; Surgery GA 014VR UT WOS:000309404300002 PM 22921384 ER PT J AU Evangelista, JW Avedisian, CT Tsang, W AF Evangelista, John W. Avedisian, C. Thomas Tsang, Wing TI Thermal and catalytic decomposition of aqueous ethylene glycol mixtures by film boiling SO INTERNATIONAL JOURNAL OF HEAT AND MASS TRANSFER LA English DT Article DE Film boiling; Catalysis; Thermal decomposition; Heat transfer; Critical heat flux; Ethylene glycol; Synthesis gas ID CARBON NANOTUBES; ORGANIC LIQUIDS; REACTOR; PYROLYSIS; HYDROGEN AB Aqueous ethylene glycol (EG) mixtures are decomposed by film boiling at near saturation temperatures on a horizontal tube in a stagnant pool containing up to 20% (volume) water. The reactor volume is the vapor layer that blankets the tube in the film boiling regime. Chemical reactions are promoted within the vapor film by the tube temperatures while the bulk liquid is close to its bubble point temperature. Experiments are carried out on bare tubes and tubes coated with nickel and platinum catalysts to show the effects involved. Results show that chemical conversion of the hydrocarbon vapors produces primarily CO and H-2. Product yields (flow rates) are enhanced on a catalyst, with an 80%EG/20%water mixture (volume percent) showing three to four times higher product yields compared to a bare tube. Platinum coatings showed slightly higher yields than nickel coatings. Diluting ethylene glycol with water decreases the overall chemical reactivity owing to preferential vaporization of water that enriches the film with steam. The presence of steam in the vapor film appears to reduce carbon deposition or "coking" on the tube when enrichment by steam is significant: deposits were observed for pure EG and 90%EG/10%water mixtures but not for 80%EG/20%water mixtures. (C) 2012 Elsevier Ltd. All rights reserved. C1 [Evangelista, John W.; Avedisian, C. Thomas; Tsang, Wing] Cornell Univ, Sibley Sch Mech & Aerosp Engn, Ithaca, NY 14853 USA. RP Evangelista, JW (reprint author), US Mil Acad, Dept Civil & Mech Engn, West Point, NY 10996 USA. EM jweaee@gmail.com FU NSF [CTS-0933521] FX This research was supported by NSF grant no. CTS-0933521. The authors appreciate the useful insights and help offered by Dr. Sung Choi on the experimental design and procedures. Dr. William B. Retallic of Catacel Corporation is thanked for his assistance with fabricating the catalyst coatings. NR 19 TC 4 Z9 4 U1 1 U2 22 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0017-9310 J9 INT J HEAT MASS TRAN JI Int. J. Heat Mass Transf. PD NOV PY 2012 VL 55 IS 23-24 BP 6425 EP 6434 DI 10.1016/j.ijheatmasstransfer.2012.06.030 PG 10 WC Thermodynamics; Engineering, Mechanical; Mechanics SC Thermodynamics; Engineering; Mechanics GA 009RG UT WOS:000309042300013 ER PT J AU McDaniel, MW Nishihata, T Brooks, CA Salesses, P Iagnemma, K AF McDaniel, Matthew W. Nishihata, Takayuki Brooks, Christopher A. Salesses, Phil Iagnemma, Karl TI Terrain classification and identification of tree stems using ground-based LiDAR SO JOURNAL OF FIELD ROBOTICS LA English DT Article ID STANDING TREES; LADAR DATA; TAPER; LOCALIZATION; NAVIGATION; FORESTS AB To operate autonomously in forested terrain, unmanned ground vehicles must be able to identify the load-bearing surface of the terrain (i.e., the ground) and obstacles in the environment. To travel long distances, they must be able to track their position even when the forest canopy obstructs GPS signals, e.g., by tracking progress relative to tree stems. This paper presents a novel, robust approach for modeling the ground plane and tree stems in forests from a single viewpoint using a lightweight LiDAR scanner. Ground plane identification is implemented using a two-stage approach. The first stage, a local height-based filter, discards most nonground points. The second stage, based on a support vector machine classifier, identifies which of the remaining points belong to the ground. Main tree stems are modeled as cylinders or cones to estimate the diameter 130 cm above the ground plane. To fit these models, candidate main stem data are selected by finding points approximately 130 cm above the ground. These points are clustered into separate point clouds for each stem. Cylinders and cones are fit to each point cloud, and heuristic filters identify which fits correspond to tree stems. Experimental results from five forested environments demonstrate the effectiveness of this approach. For ground plane estimation, the overall classification accuracy was 86.28% with a mean error for the ground height of approximately 4.7 cm. For stem estimation, up to 50% of the main stems were accurately modeled using cones, with a root mean square diameter error of 13.2 cm.(c) 2012 Wiley Periodicals, Inc. C1 [McDaniel, Matthew W.; Nishihata, Takayuki; Brooks, Christopher A.; Salesses, Phil; Iagnemma, Karl] MIT, Dept Mech Engn, Cambridge, MA 02139 USA. [Salesses, Phil] USA, Engineer Res & Dev Ctr, Alexandria, VA 22315 USA. RP Brooks, CA (reprint author), MIT, Dept Mech Engn, Cambridge, MA 02139 USA. EM mmcdaniel@alum.mit.edu; takayuki_nishihata@komatsu.co.jp; cabrooks@alum.mit.edu; salesses@mit.edu; kdi@mit.edu FU U.S. Army Research Office [W912HZ-08-C-0060]; U.S. Army Topographic Engineering Center [W911NF-07-1-0540] FX This work was supported by the U.S. Army Research Office (contract #W912HZ-08-C-0060) and the U.S. Army Topographic Engineering Center (contract #W911NF-07-1-0540). NR 23 TC 14 Z9 15 U1 1 U2 29 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1556-4959 J9 J FIELD ROBOT JI J. Field Robot. PD NOV-DEC PY 2012 VL 29 IS 6 BP 891 EP 910 DI 10.1002/rob.21422 PG 20 WC Robotics SC Robotics GA 015PA UT WOS:000309457200004 ER PT J AU Hammamieh, R Chakraborty, N De Lima, TCM Meyerhoff, J Gautam, A Muhie, S D'Arpa, P Lumley, L Carroll, E Jett, M AF Hammamieh, Rasha Chakraborty, Nabarun De Lima, Thereza C. M. Meyerhoff, James Gautam, Aarti Muhie, Seid D'Arpa, Peter Lumley, Lucille Carroll, Erica Jett, Marti TI Murine model of repeated exposures to conspecific trained aggressors simulates features of post-traumatic stress disorder SO BEHAVIOURAL BRAIN RESEARCH LA English DT Article DE PTSD; Stress effects; Avoidance; Dendritic spines; Cardiovascular disease ID MEDIAL PREFRONTAL CORTEX; SOCIAL-DEFEAT STRESS; GERBILS MERIONES-UNGUICULATUS; ANXIETY-LIKE BEHAVIOR; CHRONIC MILD STRESS; ANIMAL-MODELS; MALE-MICE; PREPULSE INHIBITION; AGONISTIC BEHAVIOR; GROOMING BEHAVIOR AB We evaluated repeated exposures of mice to a trained aggressor mouse as a model (adapted from "social stress" models of traumatic stress) for aspects of post-traumatic stress disorder (PTSD). Using a "cage-within-cage resident-intruder" protocol, subject C57BL/6J mice were exposed to aggressors for 6 h daily for 5 or 10 days. At one to three random times during each 6-h session, subjects were exposed directly to aggressor for 1 min or 10 bites, whichever came first. Behavioral, physiological, and histological changes associated with aggressor-exposure were assessed for up to 6 weeks. During aggressor exposure, subjects displayed less territorial behavior, gained weight, and increased body temperature. One day after the last aggressor exposure, inflammatory cardiac histopathologies were prevalent; after 10 days, only mild myocardial degeneration with fibrosis or fibroplasias was evident, while controls showed almost no cardiac abnormalities at any time. After 4 weeks, the medial prefrontal cortex of control mice showed increased dendritic spine density, but aggressor-exposed mice showed no increase. Behaviors affected by aggressor exposure were evaluated in a partition test wherein the subject mouse is separated from the aggressor by a fenestrated partition that permits sensory cues to pass but prevents direct physical interaction. For up to 4-6 weeks after the last aggressor exposure, subjects showed prolonged grooming, freezing, retarded locomotion and no tail rattling. PTSD and its co-morbidities are often consequent to repeated aggravated "social" assaults (e.g., combat) and manifest socially over time, suggesting the relevance of this repeated aggressor-exposure model to clinical aspects of PTSD. Published by Elsevier B.V. C1 [Hammamieh, Rasha; Chakraborty, Nabarun; Meyerhoff, James; Gautam, Aarti; Muhie, Seid; D'Arpa, Peter; Jett, Marti] USA, Ctr Environm Hlth Res, Ft Detrick, MD USA. [De Lima, Thereza C. M.] Univ Fed Santa Catarina, Dept Pharmacol, Florianopolis, SC, Brazil. [Lumley, Lucille] USA, Med Res Inst Chem Def, Aberdeen, MD USA. [Carroll, Erica] USN, Med Res Ctr, Silver Spring, MD USA. RP Hammamieh, R (reprint author), 568 Doughten Dr, Ft Detrick, MD 21702 USA. EM Rasha.Hammamieh1@us.army.mil RI Lima, Thereza/C-6812-2015 OI Lima, Thereza/0000-0002-3253-7350 FU U.S. Army Medical Research and Materiel Command; Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq) FX This research was sponsored by the U.S. Army Medical Research and Materiel Command and had the financial support of the Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq), which provided a sabbatical grant to Dr. T.C.M. De Lima. The authors would like to thank Stacy-Ann Miller, Monique Melige, Bintu Sowe, Seshamalini Srinivasan, and Meskerem Jibitu for their technical support and assistance. NR 105 TC 12 Z9 12 U1 1 U2 14 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0166-4328 J9 BEHAV BRAIN RES JI Behav. Brain Res. PD NOV 1 PY 2012 VL 235 IS 1 BP 55 EP 66 DI 10.1016/j.bbr.2012.07.022 PG 12 WC Behavioral Sciences; Neurosciences SC Behavioral Sciences; Neurosciences & Neurology GA 010LM UT WOS:000309095900008 PM 22824590 ER PT J AU Mathaudhu, SN Huang, XX Kim, HS Langdon, TG Lowe, TC Valiev, RZ Wu, XL Zehetbauer, M Zhu, YTT AF Mathaudhu, Suveen N. Huang, Xiaoxu Kim, Hyoung Seop Langdon, Terence G. Lowe, Terry C. Valiev, Ruslan Z. Wu, Xiaolei Zehetbauer, Michael Zhu, Yuntian T. TI Preface to the special issue on ultrafine-grained materials SO JOURNAL OF MATERIALS SCIENCE LA English DT Editorial Material C1 [Zhu, Yuntian T.] N Carolina State Univ, Dept Mat Sci & Engn, Raleigh, NC 27695 USA. [Mathaudhu, Suveen N.] USA, Div Mat Sci, Res Off, Durham, NC USA. [Huang, Xiaoxu] Riso Natl Lab, DK-4000 Roskilde, Denmark. [Kim, Hyoung Seop] POSTECH Pohang Univ Sci & Technol, Dept Mat Sci & Engn, Pohang 790784, Gyungbuk, South Korea. [Langdon, Terence G.] Univ So Calif, Dept Aerosp & Mech Engn, Los Angeles, CA 90089 USA. [Lowe, Terry C.] Metallicum Inc, Santa Fe, NM USA. [Valiev, Ruslan Z.] Ufa State Aviat Tech Univ, Inst Phys Adv Mat, Ufa 450000, Russia. [Wu, Xiaolei] Chinese Acad Sci, Inst Mech, State Key Lab Nonlinear Mech, Beijing 100190, Peoples R China. [Wu, Xiaolei] Chinese Acad Sci, Inst Mech, Mat Res Ctr, Beijing 100190, Peoples R China. [Zehetbauer, Michael] Univ Vienna, Fac Phys, A-1090 Vienna, Austria. RP Zhu, YTT (reprint author), N Carolina State Univ, Dept Mat Sci & Engn, Box 7907, Raleigh, NC 27695 USA. EM suveen.n.mathaudhu.civ@mail.mil; xihu@dtu.dk; hskim@postech.edu; langdon@usc.edu; terry@mhtx.com; rzvaliev@mail.rb.ru; xlwu@imech.ac.cn; michael.zehetbauer@univie.ac.at; ytzhu@ncsu.edu RI Kim, Hyoung Seop/C-2166-2009; Mathaudhu, Suveen/B-4192-2009; Zhu, Yuntian/B-3021-2008 OI Kim, Hyoung Seop/0000-0002-3155-583X; Zhu, Yuntian/0000-0002-5961-7422 NR 0 TC 2 Z9 2 U1 2 U2 24 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0022-2461 J9 J MATER SCI JI J. Mater. Sci. PD NOV PY 2012 VL 47 IS 22 BP 7717 EP 7718 DI 10.1007/s10853-012-6735-1 PG 2 WC Materials Science, Multidisciplinary SC Materials Science GA 000BX UT WOS:000308362600001 ER PT J AU Mohan, P Shekhar, S Shine, JA Rogers, JP AF Mohan, Pradeep Shekhar, Shashi Shine, James A. Rogers, James P. TI Cascading Spatio-Temporal Pattern Discovery SO IEEE TRANSACTIONS ON KNOWLEDGE AND DATA ENGINEERING LA English DT Article DE Cascading spatiotemporal patterns; space-time K-function; cascade participation index; spatiotemporal join; spatiotemporal continuity; positive ST autocorrelation; spatiotemporal partial order ID DATA SETS AB Given a collection of Boolean spatiotemporal (ST) event-types, the cascading spatiotemporal pattern (CSTP) discovery process finds partially ordered subsets of these event-types whose instances are located together and occur serially. For example, analysis of crime data sets may reveal frequent occurrence of misdemeanors and drunk driving after and near bar closings on weekends, as well as after and near large gatherings such as football games. Discovering CSTPs from ST data sets is important for application domains such as public safety (e. g., identifying crime attractors and generators) and natural disaster planning, (e. g., preparing for hurricanes). However, CSTP discovery presents multiple challenges; three important ones are 1) the exponential cardinality of candidate patterns with respect to the number of event types, 2) computationally complex ST neighborhood enumeration required to evaluate the interest measure and 3) the difficulty of balancing computational complexity and statistical interpretation. Current approaches for ST data mining focus on mining totally ordered sequences or unordered subsets. In contrast, our recent work explores partially ordered patterns. Recently, we represented CSTPs as directed acyclic graphs (DAGs); proposed a new interest measure, the cascade participation index (CPI); outlined the general structure of a cascading spatiotemporal pattern miner (CSTPM); evaluated filtering strategies to enhance computational savings using a real-world crime data set and proposed a nested loop-based CSTPM to address the challenge posed by exponential cardinality of candidate patterns. This paper adds to our recent work by offering a new computational insight, namely, that the computational bottleneck for CSTP discovery lies in the interest measure evaluation. With this insight, we propose a new CSTPM based on spatiotemporal partitioning that significantly lowers the cost of interest measure evaluation. Analytical evaluation shows that our new CSTPM is correct and complete. Results from significant amount of new experimental evaluation with both synthetic and real data show that our new ST partitioning-based CSTPM outperforms the CSTPM from our previous work. We also present a case study that verifies the applicability of CSTP discovery process. C1 [Mohan, Pradeep; Shekhar, Shashi] Univ Minnesota, Dept Comp Sci, Minneapolis, MN 55455 USA. [Shine, James A.; Rogers, James P.] USA, Engn Res & Dev Ctr, Corps Engineers, Alexandria, VA USA. [Shine, James A.] USA, Topog Engn Ctr, Alexandria, VA USA. [Rogers, James P.] USA, Engineer Res & Dev Ctr, Alexandria, VA USA. RP Mohan, P (reprint author), Univ Minnesota, Dept Comp Sci, 4-192 Keller Hall,200 Union St, Minneapolis, MN 55455 USA. EM mohan@cs.umn.edu; shekhar@cs.umn.edu; James.A.Shine@usace.army.mil; James.P.Rogers.II@usace.army.mil FU US Army Corps of Engineers; US Department of Defense FX The authors would like to thank Kim Koffolt, Nicole Wayant, Katlyn Winter, and the members of the spatial database and data mining research group at the University of Minnesota for their helpful comments. They are especially grateful to Mr. Tom Casady, Chief of Police, Lincoln City Police Department, Lincoln, Nebraska for providing us with real ST crime data sets. This work was supported in part by the US Army Corps of Engineers and the US Department of Defense. NR 32 TC 6 Z9 6 U1 2 U2 13 PU IEEE COMPUTER SOC PI LOS ALAMITOS PA 10662 LOS VAQUEROS CIRCLE, PO BOX 3014, LOS ALAMITOS, CA 90720-1314 USA SN 1041-4347 J9 IEEE T KNOWL DATA EN JI IEEE Trans. Knowl. Data Eng. PD NOV PY 2012 VL 24 IS 11 BP 1977 EP 1992 DI 10.1109/TKDE.2011.146 PG 16 WC Computer Science, Artificial Intelligence; Computer Science, Information Systems; Engineering, Electrical & Electronic SC Computer Science; Engineering GA 009AL UT WOS:000308997600005 ER PT J AU Brown, MA Evans, JL AF Brown, Michael A. Evans, Jeffrey L. TI Fatigue life variability due to variations in interference fit of steel bushings in 7075-T651 aluminum lugs SO INTERNATIONAL JOURNAL OF FATIGUE LA English DT Article DE Aerospace; Aluminum alloy; Fatigue strength; Life prediction; S-N curves ID STRENGTH AB Fatigue of metallic components is a concern in rotary wing aircraft. There exists a potential for loss of an aircraft if a component fatigue life does not take into account all factors than can cause life variation. Much literature was located dealing with the impact of large interference fits and cold working. Literature covering small changes was lacking. This study focused on small changes in interference such as those that could come from a tolerance on a drawing. Testing was completed on 7075-T651 Aluminum alloy lugs with steel bushings of varying interference fit. Testing three different levels of interference fit revealed three different S-N curves even though the variation from fit to fit was small. Significant improvements can be achieved in the S-N curve simply by small changes in interference. From a safety point of view these changes should be looked at as potential reductions. (C) 2012 Elsevier Ltd. All rights reserved. C1 [Brown, Michael A.; Evans, Jeffrey L.] Univ Alabama Huntsville, Dept Mech & Aerosp Engn, Huntsville, AL USA. [Brown, Michael A.] USA, Aviat Engn Directorate, Washington, DC USA. RP Evans, JL (reprint author), Univ Alabama Huntsville, Dept Mech & Aerosp Engn, Huntsville, AL USA. EM jeff.evans@uah.edu FU US Army, Aviation Engineering Directorate FX The authors would like to thank the US Army, Aviation Engineering Directorate, for funding that was used to offset some of the costs associated with specimen manufacture and testing. The authors would also like to thank Royal Ritchey at the UAH Research Machine Shop. In addition to manufacturing the lugs, performing final component assembly and manufacturing the test fixture clevis, Mr. Ritchey provided valuable input in the field of machining that was taken into consideration when deciding how to make parts and which type of test to run. NR 22 TC 1 Z9 1 U1 1 U2 13 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0142-1123 J9 INT J FATIGUE JI Int. J. Fatigue PD NOV PY 2012 VL 44 BP 177 EP 187 DI 10.1016/j.ijfatigue.2012.05.001 PG 11 WC Engineering, Mechanical; Materials Science, Multidisciplinary SC Engineering; Materials Science GA 996AT UT WOS:000308057100019 ER PT J AU White, MJ Swenson, GW Borrowman, TA Borth, JD AF White, Michael J. Swenson, George W., Jr. Borrowman, Todd A. Borth, Jeffrey D. TI Low-frequency sound propagation in porous media: Glass spheres and pea gravel SO APPLIED ACOUSTICS LA English DT Article DE Sound absorption; Characteristic impedance; Granular medium ID SATURATED RANDOM PACKINGS; TORTUOSITY; MODELS; BEADS AB The sound propagation properties of two air-filled granular materials: large sifted pea gravel and 10 mm diameter glass spheres have been measured in an impedance tube. The experimental method was essentially the same as reported earlier [Swenson et al. Low-frequency sound wave parameter measurement in gravels. Appl Acoust 2010; 71: 45-51] for two other kinds of gravel: crushed limestone and undifferentiated pea gravel. Additional sampling and processing steps were applied to the microphone signals such that instead of tones, band-limited random noise was used as the input signal, and spectral domain complex pressures are now offered as input to the estimation algorithm. The estimation process extracts the best-fit attenuation coefficient, phase velocity, and characteristic impedance for the material over the signal frequencies, all with better precision than we previously obtained. Quadratic approximations for the acoustical parameters are given over the frequency range 25-160 Hz. The media are both slightly attenuating and dispersive, having attenuation coefficients within 0.13-0.34 Np/m, phase velocities smaller than those in air (180-240 m/s), and characteristic impedance approximately 3-5 times that for air. Pea gravel was more attenuating, and had slightly higher characteristic impedance, but lower phase velocities than the glass spheres. Published by Elsevier Ltd. C1 [White, Michael J.] ERDC, CERL, Champaign, IL 61826 USA. [Swenson, George W., Jr.; Borrowman, Todd A.; Borth, Jeffrey D.] Univ Illinois, Dept Elect & Comp Engn, Urbana, IL 61801 USA. RP White, MJ (reprint author), ERDC, CERL, POB 9005, Champaign, IL 61826 USA. EM michael.j.white@usace.army.mil RI White, Michael/B-3612-2009 OI White, Michael/0000-0001-8450-9135 FU US Army Construction Engineering Research Laboratory of the US Army Engineering Research and Development Center under the Great Rivers Cooperative Ecosystems Studies Unit [W9132T-09-2-0008]; University of Illinois at Urbana-Champaign FX This work was supported by the US Army Construction Engineering Research Laboratory of the US Army Engineering Research and Development Center under the Great Rivers Cooperative Ecosystems Studies Unit Agreement, No. W9132T-09-2-0008, with the University of Illinois at Urbana-Champaign. The authors acknowledge the contributions of Timothy Onder, Tyler Rossi, Jeffery Mifflin, and Bruce MacAllister. The physical measurements were made on the premises and with the facilities of the Construction Engineering Research Laboratory. NR 12 TC 0 Z9 2 U1 1 U2 23 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0003-682X J9 APPL ACOUST JI Appl. Acoust. PD NOV PY 2012 VL 73 IS 11 BP 1146 EP 1149 DI 10.1016/j.apacoust.2012.05.007 PG 4 WC Acoustics SC Acoustics GA 987PI UT WOS:000307429200008 ER PT J AU Gillespie, JW Carlsson, LA Gawandi, AA Bogetti, TA AF Gillespie, J. W., Jr. Carlsson, L. A. Gawandi, A. A. Bogetti, T. A. TI Fatigue crack growth at the face sheet-core interface in a discontinuous ceramic-tile cored sandwich structure SO COMPOSITE STRUCTURES LA English DT Article DE Fatigue; Sandwich structures; Discontinous core; Ceramic tile; Armor ID BONDED JOINTS; FRACTURE; MECHANICS; SHEAR; BEAMS AB The fatigue failure mechanism of a sandwich structure with discontinuous ceramic tile core is characterized. The sandwich structure in consideration comprises ceramic core tiles bonded to composite face sheet with a compliant adhesive layer. The discontinuous nature of the core results in a non-uniform stress field under in-plane loading of the sandwich. Static tensile tests performed on sandwich coupons revealed first damage as debonding at the gaps between adjacent tiles in the core. Tension-tension fatigue tests caused debonding at the gaps followed by initiation of cracks in the adhesive layer between the face sheet and core. Experimental data for crack length versus number of cycles is collected at various load levels. Crack growth rates (da/dN) are determined based on the experimental data acquired. The energy release rate available for crack propagation is computed using an analytical model and finite element analysis. Mode separation performed using the Virtual Crack Closure Technique (VCCT) revealed that crack propagation is completely dominated by shear (mode II). Fatigue crack growth behavior for the discontinuous sandwich structure is quantified by correlating the cyclic energy release rate with the rate of crack propagation. The loss of specimen stiffness with crack propagation is quantified using an analytical model. (C) 2012 Elsevier Ltd. All rights reserved. C1 [Gillespie, J. W., Jr.; Gawandi, A. A.] Univ Delaware, Ctr Composite Mat, Newark, DE 19716 USA. [Carlsson, L. A.] Florida Atlantic Univ, Dept Mech Engn, Boca Raton, FL 33431 USA. [Bogetti, T. A.] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Gillespie, JW (reprint author), Univ Delaware, Ctr Composite Mat, Newark, DE 19716 USA. EM Gillespie@udel.edu FU Army Research Laboratory FX The authors are thankful to the Army Research Laboratory for funding the research work. The authors are also grateful to Penny O'Donnell and Dawn Fiore at the Center for Composite Materials for their help in the preparation of this manuscript. NR 21 TC 5 Z9 5 U1 3 U2 19 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0263-8223 J9 COMPOS STRUCT JI Compos. Struct. PD NOV PY 2012 VL 94 IS 11 BP 3186 EP 3193 DI 10.1016/j.compstruct.2012.05.021 PG 8 WC Materials Science, Composites SC Materials Science GA 978XB UT WOS:000306778000007 ER PT J AU Bitner, S Daescu, O AF Bitner, Steven Daescu, Ovidiu TI Minimum-sum dipolar spanning tree in R-3 SO COMPUTATIONAL GEOMETRY-THEORY AND APPLICATIONS LA English DT Article; Proceedings Paper CT 19th Canadian Conference on Computational Geometry (CCCG) CY AUG 20-22, 2007 CL Ottawa, CANADA DE Computational geometry; Dipolar spanning tree; MSST; Two-center ID LINEAR-TIME ALGORITHMS; FACILITY LOCATION; 2-CENTER PROBLEM; DIAMETER AB In this paper we consider finding a geometric minimum-sum dipolar spanning tree in R-3, and present an algorithm that takes O (n(2) log(2) n) time using O(n(2)) space, thus almost matching the best known results for the planar case. Our solution uses an interesting result related to the complexity of the common intersection of n balls in R-3, of possible different radii, that are all tangent to a given point p. The problem has applications in communication networks, when the goal is to minimize the distance between two hubs or servers as well as the distance from any node in the network to the closer of the two hubs. Published by Elsevier B.V. C1 [Bitner, Steven] USA, TRADOC Anal Ctr, Ft Leavenworth, KS 66027 USA. [Daescu, Ovidiu] Univ Texas Dallas, Dept Comp Sci, Richardson, TX 75080 USA. RP Bitner, S (reprint author), USA, TRADOC Anal Ctr, Ft Leavenworth, KS 66027 USA. EM steven.p.bitner.civ@mail.mil; daescu@utdallas.edu NR 21 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0925-7721 J9 COMP GEOM-THEOR APPL JI Comput. Geom.-Theory Appl. PD NOV PY 2012 VL 45 IS 9 SI SI BP 476 EP 481 DI 10.1016/j.comgeo.2010.09.011 PG 6 WC Mathematics, Applied; Mathematics SC Mathematics GA 969GI UT WOS:000306043300002 ER PT J AU Knorr, DB Jaye, C Fischer, DA Shoch, AB Lenhart, JL AF Knorr, Daniel B., Jr. Jaye, Cherno Fischer, Daniel A. Shoch, Andrew B. Lenhart, Joseph L. TI Manipulation of Interfacial Amine Density in Epoxy-Amine Systems as Studied by Near-Edge X-ray Absorption Fine Structure (NEXAFS) SO LANGMUIR LA English DT Article ID SILANE COUPLING AGENTS; ENERGY-ABSORPTION; POLYMER LAYERS; SURFACE CHARACTERIZATION; BALLISTIC IMPACT; CARBON-FIBERS; GLASS; COMPOSITES; ADHESION; IMMOBILIZATION AB In this work, we investigate the ability to tune the quantity of surface amine functional groups in the interfacial region of epoxy-diamine composites using NEXAFS, a technique that is extremely sensitive to surface composition. Thereby, we employ a model surface (silicon wafer with the native oxide present) and, after deposition of an epoxy functionalized silane, we immersed the wafers in various diamines, followed by reaction with a diepoxy acting as a molecular probe. These results show that the number of available surface amines depends on the diamine chosen, wherein smaller molecular weight diamines provide more reaction sites. Subsequent experiments with mixtures of diamines undergoing competitive adsorption show that the amine quantity can be tailored by choice of the diamine mixture. Further experiments of diamine treated 3-(glycidoxypropyl) trimethoxysilane layers in a reacting epoxy/diamine showed that the surface reaction site density differences observed for adsorption experiments persisted in the reacting epoxy, implying that the surface reaction rate (and by extension, the surface amine concentration) dictate interfacial cross-link density up to the point of gelation. C1 [Knorr, Daniel B., Jr.; Shoch, Andrew B.; Lenhart, Joseph L.] USA, Res Lab, Aberdeen Proving Ground, MD USA. [Jaye, Cherno; Fischer, Daniel A.] NIST, Mat Sci & Engn Lab, Gaithersburg, MD 20899 USA. RP Lenhart, JL (reprint author), USA, Res Lab, Aberdeen Proving Ground, MD USA. EM joseph.l.lenhart.civ@mail.mil FU U.S. Army Research Laboratory FX Support for this work was provided by the U.S. Army Research Laboratory. NR 73 TC 4 Z9 4 U1 2 U2 28 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0743-7463 J9 LANGMUIR JI Langmuir PD OCT 30 PY 2012 VL 28 IS 43 BP 15294 EP 15304 DI 10.1021/la3033786 PG 11 WC Chemistry, Multidisciplinary; Chemistry, Physical; Materials Science, Multidisciplinary SC Chemistry; Materials Science GA 029HB UT WOS:000310484300021 PM 23013540 ER PT J AU Olinger, GG Pettitt, J Kim, D Working, C Bohorov, O Bratcher, B Hiatt, E Hume, SD Johnson, AK Morton, J Pauly, M Whaley, KJ Lear, CM Biggins, JE Scully, C Hensley, L Zeitlin, L AF Olinger, Gene Garrard, Jr. Pettitt, James Kim, Do Working, Cara Bohorov, Ognian Bratcher, Barry Hiatt, Ernie Hume, Steven D. Johnson, Ashley K. Morton, Josh Pauly, Michael Whaley, Kevin J. Lear, Calli M. Biggins, Julia E. Scully, Corinne Hensley, Lisa Zeitlin, Larry TI Delayed treatment of Ebola virus infection with plant-derived monoclonal antibodies provides protection in rhesus macaques SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA LA English DT Article DE passive immunization; therapy ID NONHUMAN-PRIMATES; HEMORRHAGIC-FEVER; PROPHYLAXIS; DISEASE; POLYMORPHISM; VACCINATION; EXPRESSION; IGG AB Filovirus infections can cause a severe and often fatal disease in humans and nonhuman primates, including great apes. Here, three anti-Ebola virus mouse/human chimeric mAbs (c13C6, h-13F6, and c6D8) were produced in Chinese hamster ovary and in whole plant (Nicotiana benthamiana) cells. In pilot experiments testing a mixture of the three mAbs (MB-003), we found that MB-003 produced in both manufacturing systems protected rhesus macaques from lethal challenge when administered 1 h postinfection. In a pivotal follow-up experiment, we found significant protection (P < 0.05) when MB-003 treatment began 24 or 48 h postinfection (four of six survived vs. zero of two controls). In all experiments, surviving animals that received MB-003 experienced little to no viremia and had few, if any, of the clinical symptoms observed in the controls. The results represent successful postexposure in vivo efficacy by a mAb mixture and suggest that this immunoprotectant should be further pursued as a postexposure and potential therapeutic for Ebola virus exposure. C1 [Olinger, Gene Garrard, Jr.; Pettitt, James; Lear, Calli M.; Biggins, Julia E.; Scully, Corinne; Hensley, Lisa] USA, Med Res Inst Infect Dis, Div Virol, Frederick, MD 21702 USA. [Kim, Do; Bohorov, Ognian; Pauly, Michael; Whaley, Kevin J.; Zeitlin, Larry] Mapp Biopharmaceut Inc, San Diego, CA 92121 USA. [Working, Cara; Bratcher, Barry; Hiatt, Ernie; Hume, Steven D.; Johnson, Ashley K.; Morton, Josh] Kentucky BioProc LLC, Owensboro, KY 42301 USA. RP Olinger, GG (reprint author), USA, Med Res Inst Infect Dis, Div Virol, Frederick, MD 21702 USA. EM gene.olinger@us.army.mil; larry.zeitlin@mappbio.com OI Olinger, Gene/0000-0001-7338-0292 FU National Institute of Allergy and Infectious Diseases [AI61270, AI 72915]; Department of Defense [DAMD 17-02-2-0015]; Defense Threat Reduction Agency [4.10007-08-RD-B] FX We thank Dr. Yuri Gleba for providing access to the magnICON expression system; Dr. Herta Steinkellner for access to the Delta XT/FT N. benthamiana; and the Veterinarian and Pathology Division staff at USAMRIID for assistance with this study. This work was supported by National Institute of Allergy and Infectious Diseases Grants AI61270 and AI 72915 and Department of Defense Grant DAMD 17-02-2-0015, and partially supported by Defense Threat Reduction Agency Grant 4.10007-08-RD-B. NR 41 TC 133 Z9 140 U1 14 U2 78 PU NATL ACAD SCIENCES PI WASHINGTON PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA SN 0027-8424 J9 P NATL ACAD SCI USA JI Proc. Natl. Acad. Sci. U. S. A. PD OCT 30 PY 2012 VL 109 IS 44 BP 18030 EP 18035 DI 10.1073/pnas.1213709109 PG 6 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 038BJ UT WOS:000311149900072 PM 23071322 ER PT J AU Kaba, SA McCoy, ME Doll, TAPF Brando, C Guo, Q Dasgupta, D Yang, YK Mittelholzer, C Spaccapelo, R Crisanti, A Burkhard, P Lanar, DE AF Kaba, Stephen A. McCoy, Margaret E. Doll, Tais A. P. F. Brando, Clara Guo, Qin Dasgupta, Debleena Yang, Yongkun Mittelholzer, Christian Spaccapelo, Roberta Crisanti, Andrea Burkhard, Peter Lanar, David E. TI Protective Antibody and CD8(+) T-Cell Responses to the Plasmodium falciparum Circumsporozoite Protein Induced by a Nanoparticle Vaccine SO PLOS ONE LA English DT Article ID DENDRITIC CELLS; DNA VACCINE; MALARIA PARASITES; IFN-GAMMA; DELIVERY; SPOROZOITES; IMMUNITY; DESIGN; VIVAX AB Background: The worldwide burden of malaria remains a major public health problem due, in part, to the lack of an effective vaccine against the Plasmodium falciparum parasite. An effective vaccine will most likely require the induction of antigen specific CD8(+) and CD4(+) T-cells as well as long-lasting antibody responses all working in concert to eliminate the infection. We report here the effective modification of a self-assembling protein nanoparticle (SAPN) vaccine previously proven effective in control of a P. berghei infection in a rodent model to now present B- and T-cell epitopes of the human malaria parasite P. falciparum in a platform capable of being used in human subjects. Methodology/Principal Findings: To establish the basis for a SAPN-based vaccine, B- and CD8(+) T-cell epitopes from the P. falciparum circumsporozoite protein (PfCSP) and the universal CD4 T-helper epitope PADRE were engineered into a versatile small protein (similar to 125 amino acids) that self-assembles into a spherical nanoparticle repetitively displaying the selected epitopes. P. falciparum epitope specific immune responses were evaluated in mice using a transgenic P. berghei malaria parasite of mice expressing the human malaria full-length P. falciparum circumsporozoite protein (Tg-Pb/PfCSP). We show that SAPN constructs, delivered in saline, can induce high-titer, long-lasting (1 year) protective antibody and poly-functional (IFN gamma(+), IL-2(+)) long-lived central memory CD8(+) T-cells. Furthermore, we demonstrated that these Ab or CD8(+) T-cells can independently provide sterile protection against a lethal challenge of the transgenic parasites. Conclusion: The SAPN construct induces long-lasting antibody and cellular immune responses to epitope specific sequences of the P. falciparum circumsporozoite protein (PfCSP) and prevents infection in mice by a transgenic P. berghei parasite displaying the full length PfCSP. C1 [Kaba, Stephen A.; McCoy, Margaret E.; Brando, Clara; Guo, Qin; Dasgupta, Debleena; Lanar, David E.] Walter Reed Army Inst Res, Malaria Vaccine Branch, Silver Spring, MD 20910 USA. [Doll, Tais A. P. F.; Yang, Yongkun; Burkhard, Peter] Univ Connecticut, Inst Mat Sci, Storrs, CT USA. [Mittelholzer, Christian] Univ Basel, ME Muller Inst Struct Biol, Basel, Switzerland. [Spaccapelo, Roberta] Univ Perugia, Dept Expt Med, Microbiol Sect, I-06100 Perugia, Italy. [Crisanti, Andrea] Univ London Imperial Coll Sci Technol & Med, London, England. [Burkhard, Peter] Univ Connecticut, Dept Mol & Cell Biol, Storrs, CT USA. RP Lanar, DE (reprint author), Walter Reed Army Inst Res, Malaria Vaccine Branch, Silver Spring, MD 20910 USA. EM david.lanar@us.army.mil RI Kaba, Stephen/B-3555-2011 OI Kaba, Stephen/0000-0003-1509-2975 FU NIH [1R01AI068761-01A2]; US Military Infectious Disease Research Program FX This work was supported by NIH Grant 1R01AI068761-01A2 (PB, DEL) and the US Military Infectious Disease Research Program (DEL). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 35 TC 29 Z9 30 U1 1 U2 24 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD OCT 29 PY 2012 VL 7 IS 10 AR e48304 DI 10.1371/journal.pone.0048304 PG 11 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 032HH UT WOS:000310705300060 PM 23144750 ER PT J AU Arulanandam, BP Chetty, SL Yu, JJ Leonard, S Klose, K Seshu, J Cap, A Valdes, JJ Chambers, JP AF Arulanandam, Bernard P. Chetty, Senthilnath Lakshmana Yu, Jieh-Juen Leonard, Sean Klose, Karl Seshu, Janakiram Cap, Andrew Valdes, James J. Chambers, James P. TI Francisella DnaK Inhibits Tissue-nonspecific Alkaline Phosphatase SO JOURNAL OF BIOLOGICAL CHEMISTRY LA English DT Article ID LIVE VACCINE STRAIN; TULARENSIS SUBSP NOVICIDA; PROTECTIVE IMMUNITY; ESCHERICHIA-COLI; SERUM COMPONENTS; WHOLE-BLOOD; IN-VIVO; SCHU S4; MICE; CHALLENGE AB Following pulmonary infection with Francisella tularensis, we observed an unexpected but significant reduction of alkaline phosphatase, an enzyme normally up-regulated following inflammation. However, no reduction was observed in mice infected with a closely related Gram-negative pneumonic organism (Klebsiella pneumoniae) suggesting the inhibition may be Francisella-specific. In similar fashion to in vivo observations, addition of Francisella lysate to exogenous alkaline phosphatase (tissue-nonspecific isozyme) was inhibitory. Partial purification and subsequent proteomic analysis indicated the inhibitory factor to be the heat shock protein DnaK. Incubation with increasing amounts of anti-DnaK antibody reduced the inhibitory effect in a dose-dependent manner. Furthermore, DnaK contains an adenosine triphosphate binding domain at its N terminus, and addition of adenosine triphosphate enhances dissociation of DnaK with its target protein, e. g. alkaline phosphatase. Addition of adenosine triphosphate resulted in decreased DnaK co-immunoprecipitated with alkaline phosphatase as well as reduction of Francisella-mediated alkaline phosphatase inhibition further supporting the binding of Francisella DnaK to alkaline phosphatase. Release of DnaK via secretion and/or bacterial cell lysis into the extracellular milieu and inhibition of plasma alkaline phosphatase could promote an orchestrated, inflammatory response advantageous to Francisella. C1 [Arulanandam, Bernard P.; Chetty, Senthilnath Lakshmana; Yu, Jieh-Juen; Leonard, Sean; Klose, Karl; Seshu, Janakiram; Chambers, James P.] Univ Texas San Antonio, Dept Biol, San Antonio, TX 78249 USA. [Cap, Andrew] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Valdes, James J.] USA, Edgewood Chem Biol Command, Aberdeen Proving Ground, MD 21010 USA. RP Chambers, JP (reprint author), Univ Texas San Antonio, Dept Biol, 1 UTSA Circle, San Antonio, TX 78249 USA. EM james.chambers@UTSA.edu RI Arulanandam, Bernard/O-9501-2014 FU National Institutes of Health [AI057986]; Center of Excellence in Infection Genomics Contract [W911NF-11-1-0136]; San Antonio Life Sciences Institute [14-3300-24] FX This work was supported in part by National Institutes of Health Grant AI057986, Center of Excellence in Infection Genomics Contract W911NF-11-1-0136, and San Antonio Life Sciences Institute Grant 14-3300-24. NR 44 TC 2 Z9 2 U1 0 U2 5 PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3996 USA SN 0021-9258 J9 J BIOL CHEM JI J. Biol. Chem. PD OCT 26 PY 2012 VL 287 IS 44 BP 37185 EP 37194 DI 10.1074/jbc.M112.404400 PG 10 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA 030RT UT WOS:000310588500052 PM 22923614 ER PT J AU Hubbard, KS Gut, IM Lyman, ME Tuznik, KM Mesngon, MT McNutt, PM AF Hubbard, Kyle S. Gut, Ian M. Lyman, Megan E. Tuznik, Kaylie M. Mesngon, Mariano T. McNutt, Patrick M. TI High yield derivation of enriched glutamatergic neurons from suspension-cultured mouse ESCs for neurotoxicology research SO BMC NEUROSCIENCE LA English DT Article DE Mouse embryonic stem cells; Neurotoxicity; In vitro modeling; BoNT; LTX; Glutamate ID EMBRYONIC STEM-CELLS; ALPHA-LATROTOXIN; CORTICAL-NEURONS; IN-VITRO; RNA-SEQ; EXOCYTOSIS; DIFFERENTIATION; MICE; EXCITOTOXICITY; IDENTIFICATION AB Background: Recently, there has been a strong emphasis on identifying an in vitro model for neurotoxicity research that combines the biological relevance of primary neurons with the scalability, reproducibility and genetic tractability of continuous cell lines. Derived neurons should be homotypic, exhibit neuron-specific gene expression and morphology, form functioning synapses and consistently respond to neurotoxins in a fashion indistinguishable from primary neurons. However, efficient methods to produce neuronal populations that are suitable alternatives to primary neurons have not been available. Methods: With the objective of developing a more facile, robust and efficient method to generate enriched glutamatergic neuronal cultures, we evaluated the neurogenic capacity of three mouse embryonic stem cell (ESC) lines (R1, C57BL/6 and D3) adapted to feeder-independent suspension culture. Neurogenesis and neuronal maturation were characterized as a function of time in culture using immunological, genomic, morphological and functional metrics. The functional responses of ESNs to neurotropic toxins with distinctly different targets and mechanisms of toxicity, such as glutamate, alpha-latrotoxin (LTX), and botulinum neurotoxin (BoNT), were also evaluated. Results: Suspension-adapted ESCs expressed markers of pluripotency through at least 30 passages, and differentiation produced 97x10(6) neural progenitor cells (NPCs) per 10-cm dish. Greater than 99% of embryonic stem cell-derived neurons (ESNs) expressed neuron-specific markers by 96 h after plating and rapidly developed complex axodendritic arbors and appropriate compartmentalization of neurotypic proteins. Expression profiling demonstrated the presence of transcripts necessary for neuronal function and confirmed that ESN populations were predominantly glutamatergic. Furthermore, ESNs were functionally receptive to all toxins with sensitivities and responses consistent with primary neurons. Conclusions: These findings demonstrate a cost-effective, scalable and flexible method to produce a highly enriched glutamatergic neuron population. The functional characterization of pathophysiological responses to neurotropic toxins and the compatibility with multi-well plating formats were used to demonstrate the suitability of ESNs as a discovery platform for molecular mechanisms of action, moderate-throughput analytical approaches and diagnostic screening. Furthermore, for the first time we demonstrate a cell-based model that is sensitive to all seven BoNT serotypes with EC50 values comparable to those reported in primary neuron populations. These data providing compelling evidence that ESNs offer a neuromimetic platform suitable for the evaluation of molecular mechanisms of neurotoxicity. C1 [Hubbard, Kyle S.; Gut, Ian M.; Lyman, Megan E.; Tuznik, Kaylie M.; McNutt, Patrick M.] USA, Med Res Inst Chem Def, Aberdeen Proving Ground, MD 21010 USA. [Mesngon, Mariano T.] Madigan Army Med Ctr, Dept Clin Invest, Ft Lewis, WA 98431 USA. RP McNutt, PM (reprint author), USA, Med Res Inst Chem Def, 3100 Ricketts Point Rd, Aberdeen Proving Ground, MD 21010 USA. EM patrick.mcnutt@us.army.mil OI McNutt, Patrick/0000-0002-5703-4565 FU Defense Threat Reduction Agency-National Research Council Research Associateship Award at USAMRICD; Oak Ridge Institute for Science and Education fellowship; National Research Council Research Associateship Award at USAMRICD; Defense Threat Reduction Agency, VA; Defense Threat Reduction Agency - Joint Science and Technology Office, Medical ST Division [CBM.THRTOX.01.10.RC.021]; NIH National Institute of Allergy and Infectious Diseases [AOD12058-0001-0000] FX This research was performed while I. G. held a Defense Threat Reduction Agency-National Research Council Research Associateship Award at USAMRICD. K. H. consecutively held an Oak Ridge Institute for Science and Education fellowship and a National Research Council Research Associateship Award at USAMRICD. We thank Angela Adkins, Alexandre Katos, Megan Lyman, Marian Nelson and Adam Swartz (USAMRICD, MD) for administrative, logistical and technical assistance; and Dr. Erin Reichert for encouragement and financial support (the Defense Threat Reduction Agency, VA). This research was supported by the Defense Threat Reduction Agency - Joint Science and Technology Office, Medical S&T Division [CBM.THRTOX.01.10.RC.021] and the NIH National Institute of Allergy and Infectious Diseases (IAA number AOD12058-0001-0000). The views expressed in this article are those of the authors and do not reflect the official policy of the Department of Army, Department of Defense, or the U.S. Government. NR 45 TC 7 Z9 7 U1 1 U2 10 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1471-2202 J9 BMC NEUROSCI JI BMC Neurosci. PD OCT 24 PY 2012 VL 13 AR 127 DI 10.1186/1471-2202-13-127 PG 15 WC Neurosciences SC Neurosciences & Neurology GA 093JP UT WOS:000315188400001 PM 23095170 ER PT J AU Convertino, M Mangoubi, RS Linkov, I Lowry, NC Desai, M AF Convertino, Matteo Mangoubi, Rami S. Linkov, Igor Lowry, Nathan C. Desai, Mukund TI Inferring Species Richness and Turnover by Statistical Multiresolution Texture Analysis of Satellite Imagery SO PLOS ONE LA English DT Article ID BETA DIVERSITY; INDEPENDENT ALPHA; VEGETATION; FOREST; RESOLUTION; CLASSIFICATION; BIODIVERSITY; EVERGLADES; ENTROPY; INDEX AB Background: The quantification of species-richness and species-turnover is essential to effective monitoring of ecosystems. Wetland ecosystems are particularly in need of such monitoring due to their sensitivity to rainfall, water management and other external factors that affect hydrology, soil, and species patterns. A key challenge for environmental scientists is determining the linkage between natural and human stressors, and the effect of that linkage at the species level in space and time. We propose pixel intensity based Shannon entropy for estimating species-richness, and introduce a method based on statistical wavelet multiresolution texture analysis to quantitatively assess interseasonal and interannual species turnover. Methodology/Principal Findings: We model satellite images of regions of interest as textures. We define a texture in an image as a spatial domain where the variations in pixel intensity across the image are both stochastic and multiscale. To compare two textures quantitatively, we first obtain a multiresolution wavelet decomposition of each. Either an appropriate probability density function (pdf) model for the coefficients at each subband is selected, and its parameters estimated, or, a non-parametric approach using histograms is adopted. We choose the former, where the wavelet coefficients of the multiresolution decomposition at each subband are modeled as samples from the generalized Gaussian pdf. We then obtain the joint pdf for the coefficients for all subbands, assuming independence across subbands; an approximation that simplifies the computational burden significantly without sacrificing the ability to statistically distinguish textures. We measure the difference between two textures' representative pdf's via the Kullback-Leibler divergence (KL). Species turnover, or b diversity, is estimated using both this KL divergence and the difference in Shannon entropy. Additionally, we predict species richness, or a diversity, based on the Shannon entropy of pixel intensity. To test our approach, we specifically use the green band of Landsat images for a water conservation area in the Florida Everglades. We validate our predictions against data of species occurrences for a twenty-eight years long period for both wet and dry seasons. Our method correctly predicts 73% of species richness. For species turnover, the newly proposed KL divergence prediction performance is near 100% accurate. This represents a significant improvement over the more conventional Shannon entropy difference, which provides 85% accuracy. Furthermore, we find that changes in soil and water patterns, as measured by fluctuations of the Shannon entropy for the red and blue bands respectively, are positively correlated with changes in vegetation. The fluctuations are smaller in the wet season when compared to the dry season. Conclusions/Significance: Texture-based statistical multiresolution image analysis is a promising method for quantifying interseasonal differences and, consequently, the degree to which vegetation, soil, and water patterns vary. The proposed automated method for quantifying species richness and turnover can also provide analysis at higher spatial and temporal resolution than is currently obtainable from expensive monitoring campaigns, thus enabling more prompt, more cost effective inference and decision making support regarding anomalous variations in biodiversity. Additionally, a matrix-based visualization of the statistical multiresolution analysis is presented to facilitate both insight and quick recognition of anomalous data. C1 [Convertino, Matteo; Linkov, Igor] USA, Engn Res & Dev Ctr, Environm Lab, Risk & Decis Sci Team,Corps Engineers, Concord, MA USA. [Convertino, Matteo] Univ Florida, Inst Food & Agr Sci, Dept Agr & Biol Engn, Gainesville, FL 32611 USA. [Convertino, Matteo] Florida State Univ, Univ Florida, Florida Climate Inst, Gainesville, FL USA. [Mangoubi, Rami S.; Lowry, Nathan C.; Desai, Mukund] Charles Stark Draper Lab Inc, Algorithms & Software, Cambridge, MA USA. [Linkov, Igor] Carnegie Mellon Univ, Dept Engn & Publ Policy, Pittsburgh, PA 15213 USA. RP Convertino, M (reprint author), USA, Engn Res & Dev Ctr, Environm Lab, Risk & Decis Sci Team,Corps Engineers, Concord, MA USA. EM mconvertino@ufl.edu; mangoubi@draper.com NR 92 TC 1 Z9 1 U1 0 U2 24 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD OCT 24 PY 2012 VL 7 IS 10 AR e46616 DI 10.1371/journal.pone.0046616 PG 16 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 026VC UT WOS:000310310200016 PM 23115629 ER PT J AU Branstetter, BK Finneran, JJ Fletcher, EA Weisman, BC Ridgway, SH AF Branstetter, Brian K. Finneran, James J. Fletcher, Elizabeth A. Weisman, Brian C. Ridgway, Sam H. TI Dolphins Can Maintain Vigilant Behavior through Echolocation for 15 Days without Interruption or Cognitive Impairment SO PLOS ONE LA English DT Article ID CONTINUOUS AUDITORY VIGILANCE; BOTTLE-NOSED DOLPHINS; TURSIOPS-TRUNCATUS; STENELLA-LONGIROSTRIS; SPINNER DOLPHINS; SHARK PREDATION; CETACEAN SLEEP; HABITAT USE; EVOLUTION; RISK AB In dolphins, natural selection has developed unihemispheric sleep where alternating hemispheres of their brain stay awake. This allows dolphins to maintain consciousness in response to respiratory demands of the ocean. Unihemispheric sleep may also allow dolphins to maintain vigilant states over long periods of time. Because of the relatively poor visibility in the ocean, dolphins use echolocation to interrogate their environment. During echolocation, dolphin produce clicks and listen to returning echoes to determine the location and identity of objects. The extent to which individual dolphins are able to maintain continuous vigilance through this active sense is unknown. Here we show that dolphins may continuously echolocate and accurately report the presence of targets for at least 15 days without interruption. During a total of three sessions, each lasting five days, two dolphins maintained echolocation behaviors while successfully detecting and reporting targets. Overall performance was between 75 to 86% correct for one dolphin and 97 to 99% correct for a second dolphin. Both animals demonstrated diel patterns in echolocation behavior. A 15-day testing session with one dolphin resulted in near perfect performance with no significant decrement over time. Our results demonstrate that dolphins can continuously monitor their environment and maintain long-term vigilant behavior through echolocation. C1 [Branstetter, Brian K.; Ridgway, Sam H.] Natl Marine Mammal Fdn, San Diego, CA USA. [Finneran, James J.; Weisman, Brian C.] USA, Marine Mammal Program, Space & Naval Warfare Syst Ctr Pacific, San Diego, CA USA. [Fletcher, Elizabeth A.] Sci Applicat Int Corp, Maritime Serv Div, San Diego, CA 92121 USA. RP Branstetter, BK (reprint author), Natl Marine Mammal Fdn, San Diego, CA USA. EM brian.branstetter@nmmpfoundation.org FU U.S. Navy Marine Mammal Program FX This project was funded by the U.S. Navy Marine Mammal Program. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 36 TC 9 Z9 9 U1 10 U2 63 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD OCT 17 PY 2012 VL 7 IS 10 AR e47478 DI 10.1371/journal.pone.0047478 PG 10 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 038AF UT WOS:000311146900066 PM 23082170 ER PT J AU Hull, M Kennedy, AJ Detzel, C Vikesland, P Chappell, MA AF Hull, M. Kennedy, A. J. Detzel, C. Vikesland, P. Chappell, M. A. TI Moving beyond Mass: The Unmet Need to Consider Dose Metrics in Environmental Nanotoxicology Studies SO ENVIRONMENTAL SCIENCE & TECHNOLOGY LA English DT Editorial Material C1 [Hull, M.; Vikesland, P.] Virginia Polytech Inst & State Univ, Dept Civil & Environm Engn, Blacksburg, VA 24061 USA. [Hull, M.; Vikesland, P.] Virginia Polytech Inst & State Univ, ICTAS, Blacksburg, VA 24061 USA. [Hull, M.; Vikesland, P.] Duke Univ, Ctr Environm Implicat Nanotechnol iCENT, Durham, NC USA. [Hull, M.; Detzel, C.] NanoSafe Inc, Blacksburg, VA USA. [Kennedy, A. J.; Chappell, M. A.] USA, ERDC, Vicksburg, MS USA. RP Hull, M (reprint author), Virginia Polytech Inst & State Univ, Dept Civil & Environm Engn, Blacksburg, VA 24061 USA. EM mahull@vt.edu RI Vikesland, Peter/B-3960-2013 OI Vikesland, Peter/0000-0003-2654-5132 NR 4 TC 12 Z9 13 U1 0 U2 19 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0013-936X J9 ENVIRON SCI TECHNOL JI Environ. Sci. Technol. PD OCT 16 PY 2012 VL 46 IS 20 BP 10881 EP 10882 DI 10.1021/es3035285 PG 2 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA 020JO UT WOS:000309805000006 PM 23030824 ER PT J AU Densmore, JM Biss, MM Homan, BE McNesby, KL AF Densmore, John M. Biss, Matthew M. Homan, Barrie E. McNesby, Kevin L. TI Thermal imaging of nickel-aluminum and aluminum-polytetrafluoroethylene impact initiated combustion SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID TEFLON AB Combustion temperatures from impact initiated nickel-aluminum (NiAl) and aluminum-polytetrafluoroethylene (Al-PTFE) materials have been measured using a high-speed two-camera imaging pyrometer. The materials were launched with a nominal velocity of 1700 m/s into a sealed chamber. Upon impact into a steel anvil chemical reactions were initiated and a flame propagated through the chamber. The measured temperature after impact was 3600 K (NiAl) and 3300 K (Al-PTFE). (C) 2012 American Institute of Physics. [http://dx.doi.org/10.1063/1.4762009] C1 [Densmore, John M.] Lawrence Livermore Natl Lab, Energet Mat Ctr, Livermore, CA 94550 USA. [Biss, Matthew M.; Homan, Barrie E.; McNesby, Kevin L.] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Densmore, JM (reprint author), Lawrence Livermore Natl Lab, Energet Mat Ctr, Livermore, CA 94550 USA. EM densmore3@llnl.gov OI Biss, Matthew/0000-0003-3780-6393 FU United States Army Research Laboratory Postdoctoral Fellowship Program; U.S. Army Research Laboratory; U.S. Department of Energy, National Nuclear Security Administration [DE-AC52-07NA27344] FX This research was supported in part by an appointment to the United States Army Research Laboratory Postdoctoral Fellowship Program, administered by the Oak Ridge Associated Universities through a contract with the U.S. Army Research Laboratory.; Lawrence Livermore National Laboratory is operated by Lawrence Livermore National Security, LLC, for the U.S. Department of Energy, National Nuclear Security Administration under Contract DE-AC52-07NA27344. NR 20 TC 6 Z9 7 U1 2 U2 39 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD OCT 15 PY 2012 VL 112 IS 8 AR 084911 DI 10.1063/1.4762009 PG 5 WC Physics, Applied SC Physics GA 030VF UT WOS:000310597500160 ER PT J AU Jammalamadaka, SN Rao, SS Bhat, SV Vanacken, J Moshchalkov, VV AF Jammalamadaka, S. Narayana Rao, S. S. Bhat, S. V. Vanacken, J. Moshchalkov, V. V. TI Magnetocaloric effect and nature of magnetic transition in nanoscale Pr0.5Ca0.5MnO3 SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID REFRIGERATION; MANGANITE AB Systematic measurements pertinent to the magnetocaloric effect and nature of magnetic transition around the transition temperature are performed in the 10 nm Pr0.5Ca0.5MnO3 nanoparticles (PCMO10). Maxwell's relation is employed to estimate the change in magnetic entropy. At Curie temperature (T-C) similar to 83.5 K, the change in magnetic entropy (-Delta S-M) discloses a typical variation with a value 0.57 J/kg K, and is found to be magnetic field dependent. From the area under the curve (Delta S vs T), the refrigeration capacity is calculated at T-C similar to 83.5K and it is found to be 7.01 J/kg. Arrott plots infer that due to the competition between the ferromagnetic and anti-ferromagnetic interactions, the magnetic phase transition in PCMO10 is broadly spread over both in temperature as well as magnetic field coordinates. Upon tuning the particle size, size distribution, morphology, and relative fraction of magnetic phases, it may be possible to enhance the magnetocalorific effect further in PCMO10. (C) 2012 American Institute of Physics. [http://dx.doi.org/10.1063/1.4759372] C1 [Jammalamadaka, S. Narayana; Rao, S. S.] Katholieke Univ Leuven, INPAC Inst Nanoscale Phys & Chem, Semicond Phys Lab, B-3001 Louvain, Belgium. [Jammalamadaka, S. Narayana] Indian Inst Technol Hyderabad, Dept Phys, Yeddumailaram 502205, Andhra Pradesh, India. [Rao, S. S.] USA, Div Mat Sci, Res Off, Res Triangle Pk, NC 27709 USA. [Rao, S. S.] N Carolina State Univ, Dept Mat Sci & Engn, Raleigh, NC 27695 USA. [Rao, S. S.; Bhat, S. V.] Indian Inst Sci, Dept Phys, Bangalore 560012, Karnataka, India. RP Jammalamadaka, SN (reprint author), Katholieke Univ Leuven, INPAC Inst Nanoscale Phys & Chem, Semicond Phys Lab, Celestijnenlaan 200D, B-3001 Louvain, Belgium. EM surya@iith.ac.in; ssingam@ncsu.edu RI Vanacken, Johan/F-3026-2013; Moshchalkov, Victor/I-7232-2013 FU KU Leuven; CSIR, Government of India; UGC, India for a Basic Scientific Research Faculty Fellowship; K U Leuven Excellence financing (INPAC); Flemish Methusalem financing; IAP network of the Belgian Government FX S.N.J. would like to thank KU Leuven, for research fellowship, S. S. R. acknowledges CSIR, Government of India for fellowship. S. V. B. thanks UGC, India for a Basic Scientific Research Faculty Fellowship. This work was supported by the K U Leuven Excellence financing (INPAC), by the Flemish Methusalem financing and by the IAP network of the Belgian Government. NR 37 TC 6 Z9 6 U1 0 U2 25 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD OCT 15 PY 2012 VL 112 IS 8 AR 083917 DI 10.1063/1.4759372 PG 4 WC Physics, Applied SC Physics GA 030VF UT WOS:000310597500084 ER PT J AU Fourney, DR Skelly, AC DeVine, JG AF Fourney, Daryl R. Skelly, Andrea C. DeVine, John G. TI Treatment of Cervical Adjacent Segment Pathology A Systematic Review SO SPINE LA English DT Review DE cervical spine; adjacent segment degeneration; junctional breakdown; spondylosis; disc arthroplasty ID INTERBODY FUSION; ANTERIOR; SPINE; SURGERY; DISEASE; DECOMPRESSION; LAMINOPLASTY; ARTHRODESIS; MYELOPATHY; QUALITY AB Study Design. Systematic review. Objective. To critically review and summarize evidence on the treatment of cervical adjacent segment pathology (ASP). Summary of Background Data. Clinical ASP (CASP) refers to clinically significant symptoms and signs (radiculopathy, myelopathy, mechanical pain) that correlate with imaging evidence of degeneration at motion segments adjacent to a previous intervention. Despite growing awareness of the long-term risks of ASP, fusion is the most commonly performed type of cervical spine surgery. There are little data regarding the optimal treatment for cervical CASP. Methods. A systematic search of PubMed, the Cochrane Library, and Google Scholar for literature published through March 2, 2012, was conducted to answer 2 key questions: (1) What is the comparative effectiveness and safety of operative versus nonoperative treatments for cervical CASP?; and (2) Describe the outcomes of surgical treatment of cervical CASP. Results. A total of 5 studies were selected for inclusion. No comparative studies were found to answer question 1. We found 1 comparative study and 4 case series of more than 10 patients that addressed question 2: 2 studies described fusion (1 comparing discectomy with corpectomy), 2 evaluated laminoplasty, and 1 reported on use of artificial discs. No studies on use of laminectomy, foraminotomy, or posterior decompression and fusion were found. Two poor-quality (level of evidence III) retrospective cohort studies compared anterior cervical discectomy and fusion with corpectomy for the treatment of CASP, but 1 study was too small to draw meaningful comparisons and was considered a case series. The other reported a 37.5% risk difference favoring corpectomy; however, most patients in both treatment groups had excellent or good clinical results, and the study had significant methodological limitations that limit comparison of anterior cervical discectomy and fusion with corpectomy (nonrandomized allocation to treatment groups, limited follow-up, small numbers of patients). No studies describing subsequent development or advancement of ASP after reconstructive surgery were found. Conclusion. Surgical options to treat cervical CASP include fusion, laminoplasty, and disc arthroplasty. There are no comparative data to guide operative versus nonoperative management. Favorable results are reported for each of these operative strategies, but small patient numbers and largely retrospective methodology limit definitive conclusions. There were conflicting data regarding the risk of single-versus multilevel fusion with respect to arthrodesis rates, and very low evidence that fusions at spinal levels caudal to ASP have a higher pseudoarthrosis risk compared with rostral levels. Consensus Statement 1. Arthroplasty, laminoplasty, and fusion for treatment of cervical CASP were described in the studies found. These seem to be effective for treatment of cervical CASP. No studies on foraminotomy, laminectomy, and posterior decompression and fusion were found. Level of Evidence: Insufficient Strength of Statement: Strong Recommendation no. 1: Despite the importance of this topic, a dearth of literature was found. We recommend further studies on this topic. Level of Evidence: Insufficient Strength of Statement: Strong C1 [Fourney, Daryl R.] Univ Saskatchewan, Div Neurosurg, Neurosurg Residency Training Program, Saskatoon, SK, Canada. [Skelly, Andrea C.] Spectrum Res Inc, Tacoma, WA USA. [DeVine, John G.] Dwight D Eisenhower Army Med Ctr, Ft Gordon, GA USA. RP Fourney, DR (reprint author), 103 Hosp Dr, Saskatoon, SK S7N 0W8, Canada. EM daryl.fourney@usask.ca FU AOSpine North America, Inc.; AOSpine North America FX Supported by AOSpine North America, Inc. Analytic support for this work was provided by Spectrum Research, Inc., with funding from the AOSpine North America. NR 20 TC 2 Z9 3 U1 1 U2 8 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0362-2436 J9 SPINE JI SPINE PD OCT 15 PY 2012 VL 37 IS 22 SU S BP S113 EP S122 DI 10.1097/BRS.0b013e31826d6284 PG 10 WC Clinical Neurology; Orthopedics SC Neurosciences & Neurology; Orthopedics GA 028PP UT WOS:000310434900012 PM 22885831 ER PT J AU Mays, JW Kumar, R Sides, SW Goswami, M Sumpter, BG Hong, KL Wu, XD Russell, TP Gido, SP Avgeropoulos, A Tsoukatos, T Hadjichristidis, N Beyer, FL AF Mays, Jimmy W. Kumar, Rajeev Sides, Scott W. Goswami, Monojoy Sumpter, Bobby G. Hong, Kunlun Wu, Xiaodong Russell, Thomas P. Gido, Samuel P. Avgeropoulos, Apostolos Tsoukatos, Thodoris Hadjichristidis, Nikos Beyer, Frederick L. TI Morphologies of poly(cyclohexadiene) diblock copolymers: Effect of conformational asymmetry SO POLYMER LA English DT Article DE Morphology; Poly(cyclohexadiene); Block copolymer ID CONSISTENT-FIELD THEORY; POLYDISPERSE BLOCK-COPOLYMERS; 1,3-CYCLOHEXADIENE POLYMERS; MICROPHASE-SEPARATION; PHASE-BEHAVIOR; SUPERMOLECULAR STRUCTURES; ANIONIC-POLYMERIZATION; MAIN-CHAIN; MELTS; POLY(1,3-CYCLOHEXADIENE) AB Concerted experimental and theoretical investigations have been carried out to understand the microphase separation in diblock copolymer melts containing poly (1,3-cyclohexadiene), PCHD, as one of the constituents. In particular, we have studied diblock copolymer melts containing polystyrene (PS), polybutadiene (PB), and polyisoprene (PI) as the second block. We have systematically varied the ratio of 1,2-/1,4-microstructures of poly (1,3-cyclohexadiene) to tune the conformational asymmetry between the two blocks and characterized the effects of these changes on the morphologies using transmission electron microscopy (TEM) and small angle X-ray scattering (SAXS). Our experimental investigations reveal that the melts of PCHD-b-PB, PCHD-b-PS and PCHD-b-PI containing nearly equal fractions of each component and high percentage of 1,4-microstructures in the PCHD block form cylindrical rather than lamellar morphologies as expected in symmetric diblock copolymers. In contrast, the morphologies of PCHD-b-PB, PCHD-b-PS and PCHD-b-PI containing PCHD block with higher 1,2-microstructure are found to be disordered at 110 degrees C. The change in the morphological behavior is in good agreement with our numerical calculations using the random phase approximation and self-consistent field theory for conformationally asymmetric diblock copolymer melts. Also, the effects of composition fluctuations are studied by extending the Brazovskii-Leibler-Fredrickson-Helfand (J. Chem. Phys. 87, 697 (1987)) theory to conformationally asymmetric diblock copolymer melts. These results allow the understanding of the underlying self-assembly process that highlights the importance of the conformational asymmetry in tuning the morphologies in block copolymers. (C) 2012 Elsevier Ltd. All rights reserved. C1 [Mays, Jimmy W.] Univ Tennessee, Dept Chem, Knoxville, TN 37996 USA. [Kumar, Rajeev] Oak Ridge Natl Lab, Natl Ctr Computat Sci, Oak Ridge, TN 37831 USA. [Sides, Scott W.] Tech X Corp, Boulder, CO 80303 USA. [Goswami, Monojoy] Oak Ridge Natl Lab, Comp Sci & Math Div, Oak Ridge, TN 37831 USA. [Sumpter, Bobby G.; Hong, Kunlun] Oak Ridge Natl Lab, Ctr Nanophase Mat Sci, Oak Ridge, TN 37831 USA. [Wu, Xiaodong; Russell, Thomas P.; Gido, Samuel P.] Univ Massachusetts, Polymer Sci & Engn Dept, Amherst, MA 01003 USA. [Avgeropoulos, Apostolos] Univ Ioannina, Dept Mat Sci & Engn, GR-45110 Ioannina, Greece. [Tsoukatos, Thodoris; Hadjichristidis, Nikos] Univ Athens, Dept Chem, Athens 15771, Greece. [Beyer, Frederick L.] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Mays, JW (reprint author), Univ Tennessee, Dept Chem, 655 Buehler Hall, Knoxville, TN 37996 USA. EM jimmymays@utk.edu RI KUMAR, RAJEEV/D-2562-2010; Sumpter, Bobby/C-9459-2013; Avgeropoulos, Apostolos/I-5772-2012; Kumar, Rajeev/Q-2255-2015; Goswami, Monojoy/G-7943-2012; Hong, Kunlun/E-9787-2015 OI Sumpter, Bobby/0000-0001-6341-0355; Kumar, Rajeev/0000-0001-9494-3488; Goswami, Monojoy/0000-0002-4473-4888; Hong, Kunlun/0000-0002-2852-5111 FU Materials Science and Engineering Division, U.S. Department of Energy (DoE), Office of Basic Energy Sciences (BES) [DEAC05-00OR22725]; UT-Battelle, LLC, at Oak Ridge National Laboratory (ORNL); Scientific User Facilities Division of DOE FX This work was supported by the Materials Science and Engineering Division, U.S. Department of Energy (DoE), Office of Basic Energy Sciences (BES) under Contract No. DEAC05-00OR22725 with UT-Battelle, LLC, at Oak Ridge National Laboratory (ORNL). Part of the research was done at the Center for Nanophase Materials Sciences, which is sponsored by the Scientific User Facilities Division of DOE. This research used resources of the Oak Ridge Leadership Computing Facility at the ORNL. NR 54 TC 6 Z9 6 U1 1 U2 74 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0032-3861 EI 1873-2291 J9 POLYMER JI Polymer PD OCT 12 PY 2012 VL 53 IS 22 BP 5155 EP 5162 DI 10.1016/j.polymer.2012.08.047 PG 8 WC Polymer Science SC Polymer Science GA 023ND UT WOS:000310040800031 ER PT J AU Carlson, DW Atwood, JE AF Carlson, Daniel W. Atwood, John E. TI An Audible Case of Acute Pericarditis SO NEW ENGLAND JOURNAL OF MEDICINE LA English DT Editorial Material C1 [Carlson, Daniel W.; Atwood, John E.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. RP Carlson, DW (reprint author), Walter Reed Army Med Ctr, Washington, DC 20307 USA. EM daniel.w.carlson.mil@health.mil NR 0 TC 0 Z9 0 U1 0 U2 0 PU MASSACHUSETTS MEDICAL SOC PI WALTHAM PA WALTHAM WOODS CENTER, 860 WINTER ST,, WALTHAM, MA 02451-1413 USA SN 0028-4793 J9 NEW ENGL J MED JI N. Engl. J. Med. PD OCT 11 PY 2012 VL 367 IS 15 DI 10.1056/NEJMicm1211055 PG 1 WC Medicine, General & Internal SC General & Internal Medicine GA 018ID UT WOS:000309652700012 PM 23050547 ER PT J AU Fomovska, A Wood, RD Mui, E Dubey, JP Ferreira, LR Hickman, MR Lee, PJ Leed, SE Auschwitz, JM Welsh, WJ Sommerville, C Woods, S Roberts, C McLeod, R AF Fomovska, Alina Wood, Richard D. Mui, Ernest Dubey, Jitenter P. Ferreira, Leandra R. Hickman, Mark R. Lee, Patricia J. Leed, Susan E. Auschwitz, Jennifer M. Welsh, William J. Sommerville, Caroline Woods, Stuart Roberts, Craig McLeod, Rima TI Salicylanilide Inhibitors of Toxoplasma gondii SO JOURNAL OF MEDICINAL CHEMISTRY LA English DT Article ID CONGENITAL TOXOPLASMOSIS; MECHANISM; OOCYSTS AB Toxoplasma gondii (T. gondii) is an apicomplexan parasite that can cause eye disease, brain disease, and death, especially in congenitally infected and immune-compromised people. Novel medicines effective against both active and latent forms of the parasite are greatly needed. The current study focused on the discovery of such medicines by exploring a family of potential inhibitors whose antiapicomplexan activity has not been previously reported. Initial screening efforts revealed that niclosamide, a drug approved for anthelmintic use, possessed promising activity in vitro against T. gondii. This observation inspired the evaluation of the activity of a series of salicylanilides and derivatives. Several inhibitors with activities in the nanomolar range with no appreciable in vitro toxicity to human cells were identified. An initial structure activity relationship was explored. Four compounds were selected for evaluation in an in vivo model of infection, and two derivatives with potentially enhanced pharmacological parameters demonstrated the best activity profiles. C1 [Fomovska, Alina; Mui, Ernest; McLeod, Rima] Univ Chicago, Dept Ophthalmol & Visual Sci, Comm Genet, Inst Genom & Syst Biol,The Coll, Chicago, IL 60637 USA. [Fomovska, Alina; Mui, Ernest; McLeod, Rima] Univ Chicago, Dept Ophthalmol & Visual Sci, Comm Immunol, Inst Genom & Syst Biol,The Coll, Chicago, IL 60637 USA. [Fomovska, Alina; Mui, Ernest; McLeod, Rima] Univ Chicago, Dept Ophthalmol & Visual Sci, Comm Mol Med, Inst Genom & Syst Biol,The Coll, Chicago, IL 60637 USA. [Wood, Richard D.; Welsh, William J.] Snowdon Inc, Monmouth Jct, NJ USA. [Dubey, Jitenter P.; Ferreira, Leandra R.] ARS, USDA, Anim Nat Resources Inst, Anim Parasit Dis Lab,BARC E, Beltsville, MD 20705 USA. [Hickman, Mark R.; Lee, Patricia J.; Leed, Susan E.; Auschwitz, Jennifer M.] Walter Reed Army Inst Res, Div Expt Therapeut, Dept Discovery, Silver Spring, MD 20910 USA. [Welsh, William J.] Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Dept Pharmacol, Piscataway, NJ 08854 USA. [Sommerville, Caroline; Woods, Stuart; Roberts, Craig] Strathclyde Inst Pharm & Biomed Sci, Glasgow G4 0RE, Lanark, Scotland. RP McLeod, R (reprint author), Univ Chicago, Dept Ophthalmol & Visual Sci, Comm Genet, Inst Genom & Syst Biol,The Coll, Chicago, IL 60637 USA. EM rwood@snowdonpharma.com; welshwj@umdnj.edu; rmcleod@midway.uchicago.edu RI Roberts, Craig/B-8016-2008 OI Roberts, Craig/0000-0002-0653-835X FU NIAID-AT-SBIR [1R43AI078763-01A1]; National Institute of Allergy and Infectious Diseases [R43AI078763] FX We thank Dr. Laura Knoll (University of Wisconsin) for providing the plasmid pLK47 construct used generate insertional mutants, Kristen Wroblewski for assistance in statistical analyses of in vivo studies, Daniel Lee for assistance with preparation of the manuscript, Dr. Kaipeen Yang (Snowdon, Inc.) for expert technical assistance in the synthesis of test compounds, and Boris Streipen (University of Georgia) for providing RH-YFP parasites. This work was supported by NIAID-AT-SBIR 1R43AI078763-01A1 and by gifts from the Mann and Cornwell, Taub, Rooney-Alden, Engel, Pritzker, Harris, Zucker, Morel, Samuel, and Mussilami families. We thank K. Wroblewski for assistance with statistical analyses.; The project described was supported by award no. R43AI078763 from the National Institute of Allergy and Infectious Diseases. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institute of Allergy and Infectious Diseases or the National Institutes of Health. The opinions of researchers at Walter Reed Army Institute of Research are their own and do not reflect the views of the U.S. Army or the Department of Defense. NR 16 TC 15 Z9 15 U1 1 U2 18 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0022-2623 J9 J MED CHEM JI J. Med. Chem. PD OCT 11 PY 2012 VL 55 IS 19 BP 8375 EP 8391 DI 10.1021/jm3007596 PG 17 WC Chemistry, Medicinal SC Pharmacology & Pharmacy GA 018ES UT WOS:000309643500016 PM 22970937 ER PT J AU Carvey, CE Farina, EK Lieberman, HR AF Carvey, Christina E. Farina, Emily K. Lieberman, Harris R. TI Confidence in the efficacy and safety of dietary supplements among United States active duty army personnel SO BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE LA English DT Article DE Consumer beliefs; Military; Government regulation; Dietary supplement health and education act (DSHEA) ID ADULTS; HEALTH; CARE AB Background: United States Army Soldiers regularly use dietary supplements (DS) to promote general health, enhance muscle strength, and increase energy, but limited scientific evidence supports the use of many DS for these benefits. This study investigated factors associated with Soldiers' confidence in the efficacy and safety of DS, and assessed Soldiers' knowledge of federal DS regulatory requirements. Methods: Between 2006 and 2007, 990 Soldiers were surveyed at 11 Army bases world-wide to assess their confidence in the effectiveness and safety of DS, knowledge of federal DS regulations, demographic characteristics, lifestyle-behaviors and DS use. Results: A majority of Soldiers were at least somewhat confident that DS work as advertised (67%) and thought they are safe to consume (71%). Confidence in both attributes was higher among regular DS users than non-users. Among users, confidence in both attributes was positively associated with rank, self-rated diet quality and fitness level, education, and having never experienced an apparent DS-related adverse event. Fewer than half of Soldiers knew the government does not require manufacturers to demonstrate efficacy, and almost a third incorrectly believed there are effective pre-market federal safety requirements for DS. Conclusions: Despite limited scientific evidence supporting the purported benefits and safety of many popular DS, most Soldiers were confident that DS are effective and safe. The positive associations between confidence and DS use should be considered when developing DS-related interventions or policies. Additionally, education to clarify Soldiers' misperceptions about federal DS safety and efficacy regulations is warranted. C1 [Carvey, Christina E.; Farina, Emily K.; Lieberman, Harris R.] USA, Environm Med Res Inst, Mil Nutr Div, Natick, MA 01760 USA. RP Lieberman, HR (reprint author), USA, Environm Med Res Inst, Mil Nutr Div, Kansas St, Natick, MA 01760 USA. EM harris.lieberman@us.army.mil FU U.S. Army Medical Research and Materiel Command (USAMRMC); Department of Defense Center Alliance for Dietary Supplement Research FX This work was supported by the U.S. Army Medical Research and Materiel Command (USAMRMC) and the Department of Defense Center Alliance for Dietary Supplement Research. The opinions or assertions contained herein are the private views of the author and are not to be construed as official or as reflecting the views of the Army or the Department of Defense. Human subjects participated after giving their free and informed voluntary consent. The investigators adhered to the policies for protection of human subjects as prescribed in Army Regulation 70-25, and the research was conducted in adherence with the provisions of 32 CFR Part 219. Citations of commercial organizations and trade names in this report do not constitute an official Department of the Army endorsement or approval of the products or services of these organizations. Approved for public release; distribution is unlimited. NR 22 TC 9 Z9 9 U1 5 U2 11 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1472-6882 J9 BMC COMPLEM ALTERN M JI BMC Complement. Altern. Med. PD OCT 10 PY 2012 VL 12 AR 182 DI 10.1186/1472-6882-12-182 PG 12 WC Integrative & Complementary Medicine SC Integrative & Complementary Medicine GA 107CJ UT WOS:000316192000001 PM 23051046 ER PT J AU Yun, HC Kreft, RE Castillo, MA Ehrlich, GD Guymon, CH Crouch, HK Chung, KK Wenke, JC Hsu, JR Spirk, TL Costerton, JW Mende, K Murray, CK AF Yun, Heather C. Kreft, Rachael E. Castillo, Mayra A. Ehrlich, Garth D. Guymon, Charles H. Crouch, Helen K. Chung, Kevin K. Wenke, Joseph C. Hsu, Joseph R. Spirk, Tracy L. Costerton, J. William Mende, Katrin Murray, Clinton K. TI Comparison of PCR/Electron spray Ionization-Time-of-Flight-Mass Spectrometry versus Traditional Clinical Microbiology for active surveillance of organisms contaminating high-use surfaces in a burn intensive care unit, an orthopedic ward and healthcare workers SO BMC INFECTIOUS DISEASES LA English DT Article DE PCR/ESI-TOF-MS; Ibis; Microbiology; Contamination; Environment ID RESISTANT STAPHYLOCOCCUS-AUREUS; GRAM-NEGATIVE BACTERIA; ACINETOBACTER-BAUMANNII; ENVIRONMENTAL CONTAMINATION; GLYCOPEPTIDE RESISTANCE; INFECTION-CONTROL; MULTILOCUS PCR; IDENTIFICATION; TRANSMISSION; ENTEROCOCCI AB Background: Understanding nosocomial pathogen transmission is restricted by culture limitations. Novel platforms, such as PCR-based electron spray ionization-time-of-flight-mass spectrometry (ESI-TOF-MS), may be useful as investigational tools. Methods: Traditional clinical microbiology (TCM) and PCR/ESI-TOF-MS were used to recover and detect microorganisms from the hands and personal protective equipment of 10 burn intensive care unit (ICU) healthcare workers providing clinical care at a tertiary care military referral hospital. High-use environmental surfaces were assessed in 9 burn ICU and 10 orthopedic patient rooms. Clinical cultures during the study period were reviewed for pathogen comparison with investigational molecular diagnostic methods. Results: From 158 samples, 142 organisms were identified by TCM and 718 by PCR/ESI-TOF-MS. The molecular diagnostic method detected more organisms (4.5 +/- 2.1 vs. 0.9 +/- 0.8, p < 0.01) from 99% vs. 67% of samples (p < 0.01). TCM detected S. aureus in 13 samples vs. 21 by PCR/ESI-TOF-MS. Gram-negative organisms were less commonly identified than gram-positive by both methods; especially by TCM. Among all detected bacterial species, similar percentages were typical nosocomial pathogens (18-19%) for TCM vs. PCR/ESI-TOF-MS. PCR/ESI-TOF-MS also detected mecA in 112 samples, vanA in 13, and KPC-3 in 2. MecA was associated (p < 0.01) with codetection of coagulase negative staphylococci but not S. aureus. No vanA was codetected with enterococci; one KPC-3 was detected without Klebsiella spp. Conclusions: In this pilot study, PCR/ESI-TOF-MS detected more organisms, especially gram-negatives, compared to TCM, but the current assay format is limited by the number of antibiotic resistance determinants it covers. Further large-scale assessments of PCR/ESI-TOF-MS for hospital surveillance are warranted. C1 [Yun, Heather C.; Castillo, Mayra A.; Crouch, Helen K.; Mende, Katrin; Murray, Clinton K.] San Antonio Mil Med Ctr, San Antonio, TX USA. [Kreft, Rachael E.; Ehrlich, Garth D.; Spirk, Tracy L.; Costerton, J. William] Allegheny Singer Res Inst, Ctr Genom Sci, Pittsburgh, PA 15212 USA. [Ehrlich, Garth D.] Drexel Univ, Coll Med, Dept Microbiol & Immunol, Pittsburgh, PA USA. [Ehrlich, Garth D.] Drexel Univ, Coll Med, Dept Otolaryngol Head & Neck Surg, Pittsburgh, PA USA. [Guymon, Charles H.; Chung, Kevin K.; Wenke, Joseph C.; Hsu, Joseph R.] USA, Inst Surg Res, San Antonio, TX USA. [Mende, Katrin] Uniformed Serv Univ Hlth Sci, Infect Dis Clin Res Program, Bethesda, MD 20814 USA. RP Yun, HC (reprint author), San Antonio Mil Med Ctr, San Antonio, TX USA. EM heather.yun@amedd.army.mil; gehrlich@wpahs.org RI Valle, Ruben/A-7512-2013 FU US Army Institute of Surgical Research; Armed Forces Health Surveillance Center including the Global Emerging Infectious System FX This work was supported by the US Army Institute of Surgical Research and the Armed Forces Health Surveillance Center including the Global Emerging Infectious System. NR 43 TC 12 Z9 12 U1 0 U2 12 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1471-2334 J9 BMC INFECT DIS JI BMC Infect. Dis. PD OCT 10 PY 2012 VL 12 AR 252 DI 10.1186/1471-2334-12-252 PG 11 WC Infectious Diseases SC Infectious Diseases GA 060KK UT WOS:000312776300001 PM 23050585 ER PT J AU Vincenti, MA Campione, S de Ceglia, D Capolino, F Scalora, M AF Vincenti, Maria Antonietta Campione, Salvatore de Ceglia, Domenico Capolino, Filippo Scalora, Michael TI Gain-assisted harmonic generation in near-zero permittivity metamaterials made of plasmonic nanoshells SO NEW JOURNAL OF PHYSICS LA English DT Article ID 2ND-HARMONIC GENERATION; REFRACTIVE-INDEX; PERIODIC ARRAYS; COMPLEX-MODES; NANOPARTICLES; NANOSPHERES; CLUSTERS AB We investigate enhanced harmonic generation processes in gainassisted, near-zero permittivity metamaterials composed of spherical plasmonic nanoshells. We report the presence of narrow-band features in transmission, reflection and absorption induced by the presence of an active material inside the core of the nanoshells. The damping-compensation mechanism used to achieve the near-zero effective permittivity condition also induces a significant increase in field localization and strength and, consequently, enhancement of linear absorption. When only metal nonlinearities are considered, second- and third-harmonic generation efficiencies obtained by probing the structure in the vicinity of the near-zero permittivity condition approach values as high as 10-7 for irradiance value as low as 10 MW cm(-2). These results clearly demonstrate that a relatively straightforward path now exists for the development of exotic and extreme nonlinear optical phenomena in the kW cm(-2) range. C1 [Vincenti, Maria Antonietta; de Ceglia, Domenico] Aegis Technol Inc, Huntsville, AL 35806 USA. [Campione, Salvatore; Capolino, Filippo] Univ Calif Irvine, Dept Elect Engn & Comp Sci, Irvine, CA 92697 USA. [Scalora, Michael] USA, Charles M Bowden Res Ctr, RDECOM, Redstone Arsenal, AL 35898 USA. RP Vincenti, MA (reprint author), Aegis Technol Inc, 410 Jan Davis Dr, Huntsville, AL 35806 USA. EM mvincenti@aegistg.com RI Campione, Salvatore/A-2349-2015 OI Campione, Salvatore/0000-0003-4655-5485 NR 50 TC 22 Z9 22 U1 1 U2 18 PU IOP PUBLISHING LTD PI BRISTOL PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND SN 1367-2630 J9 NEW J PHYS JI New J. Phys. PD OCT 9 PY 2012 VL 14 AR 103016 DI 10.1088/1367-2630/14/10/103016 PG 18 WC Physics, Multidisciplinary SC Physics GA 017HU UT WOS:000309581600003 ER PT J AU Do, Y Didierlaurent, AM Ryu, S Koh, H Park, CG Park, S Perlin, DS Powell, BS Steinman, RM AF Do, Yoonkyung Didierlaurent, Arnaud M. Ryu, Seongho Koh, Hyein Park, Chae Gyu Park, Steven Perlin, David S. Powell, Bradford S. Steinman, Ralph M. TI Induction of pulmonary mucosal immune responses with a protein vaccine targeted to the DEC-205/CD205 receptor SO VACCINE LA English DT Article DE Dendritic cells; CD205/DEC-205; Y. pestis; LcrV; Cellular immunity; Mucosal ID YERSINIA-PESTIS INFECTION; PRIMARY PNEUMONIC PLAGUE; LCRV VIRULENCE PROTEIN; NECROSIS-FACTOR-ALPHA; GAMMA-INTERFERON; DENDRITIC CELLS; FUSION PROTEIN; MOUSE MODEL; PROTECTION; MICE AB It is of great interest to develop a pneumonic plague vaccine that would induce combined humoral and cellular immunity in the lung. Here we investigate a novel approach based on targeting of dendritic cells using the DEC-205/CD205 receptor (DEC) via the intranasal route as way to improve mucosal cellular immunity to the vaccine. Intranasal administration of Yersinia pestis LcrV (V) protein fused to anti-DEC antibody together with poly IC as an adjuvant induced high frequencies of IFN-gamma secreting CD4(+) T cells in the airway and lung as well as pulmonary IgG and IgA antibodies. Anti-DEC:LcrV was more efficient to induce IFN-gamma/TNF-alpha/IL-2 secreting polyfunctional CD4(+) T cells when compared to non-targeted soluble protein vaccine. In addition, the intranasal route of immunization with anti-DEC:LcrV was associated with improved survival upon pulmonary challenge with the virulent CO92 Y. pestis. Taken together, these data indicate that targeting dendritic cells via the mucosal route is a potential new avenue for the development of a mucosal vaccine against pneumonic plague. (c) 2012 Elsevier Ltd. All rights reserved. C1 [Do, Yoonkyung] Ulsan Natl Inst Sci & Technol, Sch Nanobiosci & Chem Engn, Ulsan 689805, South Korea. [Do, Yoonkyung; Didierlaurent, Arnaud M.; Koh, Hyein; Park, Chae Gyu; Steinman, Ralph M.] Rockefeller Univ, Lab Cellular Physiol & Immunol, New York, NY 10065 USA. [Do, Yoonkyung; Didierlaurent, Arnaud M.; Koh, Hyein; Park, Chae Gyu; Steinman, Ralph M.] Rockefeller Univ, Chris Browne Ctr, New York, NY 10065 USA. [Ryu, Seongho] Cornell Univ, Dept Cardiothorac Surg, Weill Cornell Med Coll, New York, NY 10065 USA. [Park, Steven; Perlin, David S.] UMDNJ New Jersey Med Sch, Int Ctr Publ Hlth, Publ Hlth Res Inst, Newark, NJ USA. [Powell, Bradford S.] USA, Med Res Inst Infect Dis, Bacteriol Div, Frederick, MD 21702 USA. RP Do, Y (reprint author), Ulsan Natl Inst Sci & Technol, Sch Nanobiosci & Chem Engn, 100 Banyeon Ri, Ulsan 689805, South Korea. EM doy@unist.ac.kr RI Do, Yoonkyung /F-5231-2010; OI Do, Yoonkyung /0000-0001-7947-4767; Park, Chae Gyu/0000-0003-1906-1308 FU National Institutes of Health [5 U54 AI057158, AI13013, 1 R21 AI082331-01]; Basic Science Research Program through the National Research Foundation of Korea (NRF); Ministry of Education, Science and Technology [2012-0003632]; National R&D Program for Cancer Control, Ministry for Health and Welfare, Republic of Korea [1020120]; Novartis Foundation FX We thank H. Zebroski of the Rockefeller University Proteomics Facility for synthesizing peptides, and J. Adams for help with the graphics. This work was supported by funds from the National Institutes of Health (#5 U54 AI057158 PI-Lipkin and AI13013, PI, RMS, and 1 R21 AI082331-01, PI, Y. Do). This study was also supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (2012-0003632), and a grant from the National R&D Program for Cancer Control, Ministry for Health and Welfare, Republic of Korea (1020120). A. Didilerlaurent was supported by a symposium bursary awarded by the Novartis Foundation. The opinions, interpretations, conclusions, and recommendations are those of the authors and are not necessarily endorsed by the U.S. Army. NR 29 TC 17 Z9 17 U1 0 U2 7 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X EI 1873-2518 J9 VACCINE JI Vaccine PD OCT 5 PY 2012 VL 30 IS 45 BP 6359 EP 6367 DI 10.1016/j.vaccine.2012.08.051 PG 9 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 024NZ UT WOS:000310117200003 PM 22947140 ER PT J AU Allen, CJ Hwang, J Kautz, R Mukerjee, S Plichta, EJ Hendrickson, MA Abraham, KM AF Allen, Chris J. Hwang, Jaehee Kautz, Roger Mukerjee, Sanjeev Plichta, Edward J. Hendrickson, Mary A. Abraham, K. M. TI Oxygen Reduction Reactions in Ionic Liquids and the Formulation of a General ORR Mechanism for Li-Air Batteries SO JOURNAL OF PHYSICAL CHEMISTRY C LA English DT Article ID ELECTROLYTE; VOLTAMMETRY; VISCOSITY; BEHAVIOR AB Oxygen reduction and evolution reactions (ORRs and OERs) have been studied in ionic liquids containing singly charged cations having a range of ionic radii, or charge densities. Specifically, ORR and OER mechanisms were studied using cyclic and rotating disk electrode voltammetry in the neat ionic liquids (ILs), 1-ethyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide (EMITFSI) and 1-methyl-1-butyl-pyrrolidinium bis-(triflouromethanesulfonyl)imide (PYR14TFSI), and in their solutions containing LiTFSI, NaPF6, KPF6, and tetrabutylammonium hexafluorophosphate (TBAPF(6)). A strong correlation was found between the ORR products and the ionic charge density, including those of the ionic liquids. The observed trend is explained in terms of the Lewis acidity of the cation present in the electrolyte using an acidity scale created from C-13 NMR chemical shifts and spin-attice relaxation (T-1) times of C-13=O in solutions of these charged ions in propylene carbonate (PC). The ionic liquids lie in a continuum of a cascading Lewis acidity scale with respect to the charge density of alkali. metal, IL, and TBA cations with the result that the ORR products in ionic liquids and in organic electrolytes containing any conducting cations can be predicted on the basis of a general theory based on the hard soft acid base (HSAB) concept. C1 [Allen, Chris J.; Hwang, Jaehee; Kautz, Roger; Mukerjee, Sanjeev; Abraham, K. M.] Northeastern Univ, NUCRET, Dept Chem & Chem Biol, Boston, MA 02115 USA. [Plichta, Edward J.; Hendrickson, Mary A.] USA, Power Div, RDER CCP, RDECOM CERDEC CP&I, Aberdeen Proving Ground, MD 21005 USA. RP Abraham, KM (reprint author), Northeastern Univ, NUCRET, Dept Chem & Chem Biol, 360 Huntington Ave,317 Egan Res Ctr, Boston, MA 02115 USA. EM kmabraham@comcast.net FU U.S. Army Cerdec [GTS-S-10-392] FX Financial support for this work was provided by the U.S. Army Cerdec through Subcontract No. GTS-S-10-392. NR 27 TC 77 Z9 79 U1 9 U2 144 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1932-7447 J9 J PHYS CHEM C JI J. Phys. Chem. C PD OCT 4 PY 2012 VL 116 IS 39 BP 20755 EP 20764 DI 10.1021/jp306718v PG 10 WC Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary SC Chemistry; Science & Technology - Other Topics; Materials Science GA 014KX UT WOS:000309375700013 ER PT J AU Fenimore, PW Muhammad, MA Fischer, WM Foley, BT Bakken, RR Thurmond, JR Yusim, K Yoon, H Parker, M Hart, MK Dye, JM Korber, B Kuiken, C AF Fenimore, Paul W. Muhammad, Majidat A. Fischer, William M. Foley, Brian T. Bakken, Russell R. Thurmond, James R. Yusim, Karina Yoon, Hyejin Parker, Michael Hart, Mary Kate Dye, John M. Korber, Bette Kuiken, Carla TI Designing and Testing Broadly-Protective Filoviral Vaccines Optimized for Cytotoxic T-Lymphocyte Epitope Coverage SO PLOS ONE LA English DT Article ID HUMAN-IMMUNODEFICIENCY-VIRUS; EBOLA HEMORRHAGIC-FEVER; MAXIMUM-LIKELIHOOD; RESPONSES; INFECTION; IMMUNITY; MONKEYS; BREADTH AB We report the rational design and in vivo testing of mosaic proteins for a polyvalent pan-filoviral vaccine using a computational strategy designed for the Human Immunodeficiency Virus type 1 (HIV-1) but also appropriate for Hepatitis C virus (HCV) and potentially other diverse viruses. Mosaics are sets of artificial recombinant proteins that are based on natural proteins. The recombinants are computationally selected using a genetic algorithm to optimize the coverage of potential cytotoxic T lymphocyte (CTL) epitopes. Because evolutionary history differs markedly between HIV-1 and filoviruses, we devised an adapted computational technique that is effective for sparsely sampled taxa; our first significant result is that the mosaic technique is effective in creating high-quality mosaic filovirus proteins. The resulting coverage of potential epitopes across filovirus species is superior to coverage by any natural variants, including current vaccine strains with demonstrated cross-reactivity. The mosaic cocktails are also robust: mosaics substantially outperformed natural strains when computationally tested against poorly sampled species and more variable genes. Furthermore, in a computational comparison of cross-reactive potential a design constructed prior to the Bundibugyo outbreak performed nearly as well against all species as an updated design that included Bundibugyo. These points suggest that the mosaic designs would be more resilient than natural-variant vaccines against future Ebola outbreaks dominated by novel viral variants. We demonstrate in vivo immunogenicity and protection against a heterologous challenge in a mouse model. This design work delineates the likely requirements and limitations on broadly-protective filoviral CTL vaccines. C1 [Fenimore, Paul W.; Fischer, William M.; Foley, Brian T.; Yusim, Karina; Yoon, Hyejin; Korber, Bette; Kuiken, Carla] Los Alamos Natl Lab, Theoret Biol & Biophys Grp, Los Alamos, NM USA. [Muhammad, Majidat A.; Bakken, Russell R.; Parker, Michael; Dye, John M.] USA, Med Res Inst Infect Dis, Div Virol, Frederick, MD USA. [Thurmond, James R.] Indiana Univ, Bloomington, IN USA. [Hart, Mary Kate] DynPort Vaccine Co, Frederick, MD USA. RP Fenimore, PW (reprint author), Los Alamos Natl Lab, Theoret Biol & Biophys Grp, Los Alamos, NM USA. EM paulf@lanl.gov OI Foley, Brian/0000-0002-1086-0296; Fischer, Will/0000-0003-4579-4062; Korber, Bette/0000-0002-2026-5757 FU Defense Threat Reduction Agency [CBM.VAXPLAT.05.10.RD.005]; USAMRIID [TA2F06062]; Los Alamos National Laboratory [20050155DR] FX Funding was provided by the Defense Threat Reduction Agency, project #CBM.VAXPLAT.05.10.RD.005 and by USAMRIID subcontract TA2F06062 and Los Alamos National Laboratory Directed Research funds 20050155DR. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 34 TC 14 Z9 14 U1 1 U2 12 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD OCT 3 PY 2012 VL 7 IS 10 AR e44769 DI 10.1371/journal.pone.0044769 PG 11 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 015NU UT WOS:000309454000004 PM 23056184 ER PT J AU Kennedy, AJ Chappell, MA Bednar, AJ Ryan, AC Laird, JG Stanley, JK Steevens, JA AF Kennedy, Alan J. Chappell, Mark A. Bednar, Anthony J. Ryan, Adam C. Laird, Jennifer G. Stanley, Jacob K. Steevens, Jeffery A. TI Impact of Organic Carbon on the Stability and Toxicity of Fresh and Stored Silver Nanoparticles SO ENVIRONMENTAL SCIENCE & TECHNOLOGY LA English DT Article ID ION-RELEASE KINETICS; BIOTIC LIGAND MODEL; DAPHNIA-MAGNA; CERIODAPHNIA-DUBIA; AQUATIC ORGANISMS; HUMIC SUBSTANCES; NANOMATERIALS; DISPERSION; PARTICLES; EXPOSURE AB Studies investigating the impact of particle size and capping agents on nanosilver toxicity in pristine laboratory conditions are becoming available. However, the relative importance of known environmental mitigating factors for dissolved silver remains poorly characterized for nanosilver in context with existing predictive toxicity models. This study investigated the implications of freshly prepared versus stored 20 and 100 nm nanosilver stocks to freshwater zooplankton (Ceriodaphnia dubia) in presence and absence of dissolved organic carbon (DOC). Results indicated that while the acute toxicity of nanosilver decreased significantly with larger size and higher DOC, storage resulted in significant increases in toxicity and ion release. The most dramatic decrease in toxicity due to DOC was observed for the 20 nm particle (2.5-6.7 fold decrease), with more modest toxicity reductions observed for the 100 nm particle (2.0-2.4 fold) and dissolved silver (2.7-3.1 fold). While a surface area dosimetry presented an improvement over mass when DOC was absent, the presence of DOC confounded its efficacy. The fraction of dissolved silver in the nanosilver suspensions was most predictive of acute toxicity regardless of system complexity. Biotic Ligand Model (BLM) predictions based on the dissolved fraction in nanosilver suspensions were comparable to observed toxicity. C1 [Kennedy, Alan J.; Chappell, Mark A.; Bednar, Anthony J.; Laird, Jennifer G.; Stanley, Jacob K.; Steevens, Jeffery A.] USA, Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS USA. [Ryan, Adam C.] HydroQual, HDR, Syracuse, NY USA. RP Kennedy, AJ (reprint author), USA, Engineer Res & Dev Ctr, Environm Lab, 3909 Halls Ferry Rd, Vicksburg, MS USA. EM Alan.J.Kennedy@usace.army.mil FU U.S. Army Environmental Quality Research Program FX This research was funded by the U.S. Army Environmental Quality Research Program (Dr. Elizabeth Ferguson, technical director). Permission was granted by the Chief of Engineers to publish this information. We thank Drs. Chris Detzel and Dr. Matthew Hull (NanoSafe) and Ms. Ashley Harmon (ERDC) for TEM analysis. Drs. Frances Hill, David Johnson and three anonymous reviewers provided thoughtful comments. NR 47 TC 41 Z9 42 U1 3 U2 86 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0013-936X J9 ENVIRON SCI TECHNOL JI Environ. Sci. Technol. PD OCT 2 PY 2012 VL 46 IS 19 BP 10772 EP 10780 DI 10.1021/es302322y PG 9 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA 015FG UT WOS:000309431200052 PM 22950762 ER PT J AU Bellan, LM Pearsall, M Cropek, DM Langer, R AF Bellan, Leon M. Pearsall, Matthew Cropek, Donald M. Langer, Robert TI A 3D Interconnected Microchannel Network Formed in Gelatin by Sacrificial Shellac Microfibers SO ADVANCED MATERIALS LA English DT Article DE vascular; hydrogel; gelatin; shellac; microfiber ID SELF-HEALING MATERIALS; MICROVASCULAR NETWORKS; VASCULAR-RESISTANCE; TISSUE; FABRICATION; HYDROGELS; SECTIONS; FLAPS C1 [Bellan, Leon M.; Pearsall, Matthew; Langer, Robert] MIT, David H Koch Inst, Cambridge, MA 02139 USA. [Cropek, Donald M.] USA, Corps Engineers, Construct Engn Res Lab, Champaign, IL 61822 USA. RP Bellan, LM (reprint author), MIT, David H Koch Inst, 77 Massachusetts Ave,Room 76-661, Cambridge, MA 02139 USA. EM Lbellan@mit.edu FU U.S. Army Engineer Research and Development Center Construction Engineering Research Laboratory (ERDC-CERL); Cancer Center from the NCI [P30-CA14051]; NIH [F32EB011866, K99EB013630] FX The authors wish to thank Ignacio Arganda-Carreras for help with the AnalyzeSkeleton plugin, and Dr. Jeffrey Borenstein for the use of the pressure measurement apparatus. This research was supported in part by the U.S. Army Engineer Research and Development Center Construction Engineering Research Laboratory (ERDC-CERL), and in part by Cancer Center Support (core) Grant P30-CA14051 from the NCI. One of the authors, LMB, gratefully acknowledges support from NIH grants F32EB011866 and K99EB013630. NR 35 TC 34 Z9 37 U1 5 U2 112 PU WILEY-V C H VERLAG GMBH PI WEINHEIM PA BOSCHSTRASSE 12, D-69469 WEINHEIM, GERMANY SN 0935-9648 J9 ADV MATER JI Adv. Mater. PD OCT 2 PY 2012 VL 24 IS 38 BP 5187 EP 5191 DI 10.1002/adma.201200810 PG 5 WC Chemistry, Multidisciplinary; Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied; Physics, Condensed Matter SC Chemistry; Science & Technology - Other Topics; Materials Science; Physics GA 011PH UT WOS:000309176800004 PM 22826135 ER PT J AU Jammalamadaka, SN Rao, SS Vanacken, J Moshchalkov, VV Lu, W Tour, JM AF Jammalamadaka, S. Narayana Rao, S. S. Vanacken, J. Moshchalkov, V. V. Lu, Wei Tour, J. M. TI Dynamic response of exchange bias in graphene nanoribbons SO APPLIED PHYSICS LETTERS LA English DT Article ID SPIN-VALVES; SPINTRONICS; ELECTRONICS; FUTURE; FILMS AB The dynamics of magnetic hysteresis, including the training effect and the field sweep rate dependence of the exchange bias, is experimentally investigated in exchange-coupled potassium split graphene nanoribbons (GNRs). We find that, at low field sweep rate, the pronounced absolute training effect is present over a large number of cycles. This is reflected in a gradual decrease of the exchange bias with the sequential field cycling. However, at high field sweep rate above 0.5 T/min, the training effect is not prominent. With the increase in field sweep rate, the average value of exchange bias field grows and is found to follow power-law behavior. The response of the exchange bias field to the field sweep rate variation is linked to the difference in the time it takes to perform a hysteresis loop measurement compared with the relaxation time of the anti-ferromagnetically aligned spins. The present results may broaden our current understanding of magnetism of GNRs and would be helpful in establishing the GNRs-based spintronic devices. (C) 2012 American Institute of Physics. [http://dx.doi.org/10.1063/1.4755840] C1 [Jammalamadaka, S. Narayana; Rao, S. S.] Katholieke Univ Leuven, INPAC, Semicond Phys Lab, B-3001 Louvain, Belgium. [Jammalamadaka, S. Narayana] Indian Inst Technol Hyderabad, Dept Phys, Yeddumailaram 502205, Andhra Pradesh, India. [Rao, S. S.] USA, Res Off, Div Mat Sci, Res Triangle Pk, NC 27709 USA. [Rao, S. S.] N Carolina State Univ, Dept Mat Sci & Engn, Raleigh, NC 27695 USA. [Lu, Wei; Tour, J. M.] Rice Univ, Dept Chem, Houston, TX 77005 USA. [Tour, J. M.] Rice Univ, Dept Mech Engn & Mat Sci, Houston, TX 77005 USA. [Tour, J. M.] Rice Univ, Smalley Inst Nanoscale Sci & Technol, Houston, TX 77005 USA. RP Jammalamadaka, SN (reprint author), Katholieke Univ Leuven, INPAC, Semicond Phys Lab, Celestijnenlaan 200D, B-3001 Louvain, Belgium. EM surya@iith.ac.in; ssingam@ncsu.edu RI Moshchalkov, Victor/I-7232-2013; Vanacken, Johan/F-3026-2013; OI Tour, James/0000-0002-8479-9328 FU K.U. Leuven; K.U. Leuven Excellence financing (INPAC); Flemish Methusalem financing; IAP network of the Belgian Government; AFOSR [FA9550-09-1-0581]; Office of Naval Research Graphene MURI Program [00006766, N00014-09-1-1066] FX S.N.J. would like to thank K.U. Leuven, for research fellowship, This work is supported by the K.U. Leuven Excellence financing (INPAC), by the Flemish Methusalem financing and by the IAP network of the Belgian Government. J.M.T. thanks Mitsui & Co., Ltd., M. Endo and A. Tanioka for generously donating the starting MWCNTs, the AFOSR (FA9550-09-1-0581) and the Office of Naval Research Graphene MURI Program (00006766, N00014-09-1-1066) for support. NR 34 TC 1 Z9 1 U1 0 U2 10 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD OCT 1 PY 2012 VL 101 IS 14 AR 142402 DI 10.1063/1.4755840 PG 5 WC Physics, Applied SC Physics GA 017PS UT WOS:000309603300061 ER PT J AU Eksi, S Morahan, BJ Haile, Y Furuya, T Jiang, HY Ali, O Xu, HC Kiattibutr, K Suri, A Czesny, B Adeyemo, A Myers, TG Sattabongkot, J Su, XZ Williamson, KC AF Eksi, Saliha Morahan, Belinda J. Haile, Yoseph Furuya, Tetsuya Jiang, Hongying Ali, Omar Xu, Huichun Kiattibutr, Kirakorn Suri, Amreena Czesny, Beata Adeyemo, Adebowale Myers, Timothy G. Sattabongkot, Jetsumon Su, Xin-zhuan Williamson, Kim C. TI Plasmodium falciparum Gametocyte Development 1 (Pfgdv1) and Gametocytogenesis Early Gene Identification and Commitment to Sexual Development SO PLOS PATHOGENS LA English DT Article ID HUMAN MALARIA PARASITE; OOCYST PRODUCTION; RISK-FACTORS; EXPRESSION; CYTOADHERENCE; CHROMOSOME-9; TRANSMISSION; EVOLUTION; PROTEINS; DIFFERENTIATION AB Malaria transmission requires the production of male and female gametocytes in the human host followed by fertilization and sporogonic development in the mosquito midgut. Although essential for the spread of malaria through the population, little is known about the initiation of gametocytogenesis in vitro or in vivo. Using a gametocyte-defective parasite line and genetic complementation, we show that Plasmodium falciparum gametocyte development 1 gene (Pfgdv1), encoding a peri-nuclear protein, is critical for early sexual differentiation. Transcriptional analysis of Pfgdv1 negative and positive parasite lines identified a set of gametocytogenesis early genes (Pfge) that were significantly down-regulated (>10 fold) in the absence of Pfgdv1 and expression was restored after Pfgdv1 complementation. Progressive accumulation of Pfge transcripts during successive rounds of asexual replication in synchronized cultures suggests that gametocytes are induced continuously during asexual growth. Comparison of Pfge gene transcriptional profiles in patient samples divided the genes into two groups differing in their expression in mature circulating gametocytes and providing candidates to evaluate gametocyte induction and maturation separately in vivo. The expression profile of one of the early gametocyte specific genes, Pfge1, correlated significantly with asexual parasitemia, which is consistent with the ongoing induction of gametocytogenesis during asexual growth observed in vitro and reinforces the need for sustained transmission-blocking strategies to eliminate malaria. C1 [Eksi, Saliha; Morahan, Belinda J.; Haile, Yoseph; Ali, Omar; Suri, Amreena; Czesny, Beata; Williamson, Kim C.] Loyola Univ, Dept Biol, Chicago, IL 60626 USA. [Morahan, Belinda J.; Furuya, Tetsuya; Jiang, Hongying; Su, Xin-zhuan; Williamson, Kim C.] NIAID, Lab Malaria & Vector Res, NIH, Bethesda, MD 20892 USA. [Xu, Huichun; Adeyemo, Adebowale] NHGRI, Ctr Res Genom & Global Hlth, Inherited Dis Res Branch, NIH, Bethesda, MD 20892 USA. [Kiattibutr, Kirakorn; Sattabongkot, Jetsumon] Armed Forces Res Inst Med Sci, Dept Entomol, US Army Med Component, Bangkok 10400, Thailand. [Myers, Timothy G.] NIAID, Genom Technol Sect, Res Technol Branch, NIH, Bethesda, MD 20892 USA. RP Eksi, S (reprint author), Loyola Univ, Dept Biol, Chicago, IL 60626 USA. EM kwilli4@luc.edu RI Furuya, Tetsuya/H-2412-2013; Furuya, Tetsuya/J-5916-2013; OI Furuya, Tetsuya/0000-0003-3979-7072; Adeyemo, Adebowale/0000-0002-3105-3231; Su, Xinzhuan/0000-0003-3246-3248 FU Public Health Service grants, National Institute of Allergy and Infectious Diseases (NIAID) [AI40592, AI48826]; Division of Intramural Research, NIAID, National Institutes of Health FX This investigation received financial support from Public Health Service grants AI40592 and AI48826 from the National Institute of Allergy and Infectious Diseases (NIAID) and the Division of Intramural Research, NIAID, National Institutes of Health. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 83 TC 22 Z9 24 U1 1 U2 17 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1553-7374 J9 PLOS PATHOG JI PLoS Pathog. PD OCT PY 2012 VL 8 IS 10 AR e1002964 DI 10.1371/journal.ppat.1002964 PG 14 WC Microbiology; Parasitology; Virology SC Microbiology; Parasitology; Virology GA 029XH UT WOS:000310530300027 PM 23093935 ER PT J AU Wildman, RA Gazonas, GA AF Wildman, Raymond A. Gazonas, George A. TI A PERFECTLY MATCHED LAYER FOR PERIDYNAMICS IN TWO DIMENSIONS SO JOURNAL OF MECHANICS OF MATERIALS AND STRUCTURES LA English DT Article DE peridynamics; perfectly matched layer; absorbing boundary ID ABSORBING BOUNDARY-CONDITION; DISCRETIZED OPERATIONAL CALCULUS; LONG-RANGE FORCES; CONVOLUTION QUADRATURE; ELASTICITY; EQUATIONS; WAVES; MEDIA AB A perfectly matched layer (PML) absorbing boundary is formulated for and numerically applied to peridynamics in two dimensions. Peridynamics is a nonlocal method, derived to be insensitive to discontinuities, more easily simulating fracture. A PML is an absorbing boundary layer, which decays impinging waves exponentially without introducing reflections at the boundary between the computational region and the absorbing layer. Here, we use state-based peridynamics as PMLs are essentially anisotropic absorbing materials, therefore requiring arbitrary material parameters. State-based peridynamics is also more convenient for auxiliary field formulations, facilitating the implementation of the PML. Results show the efficacy of the approach. C1 [Wildman, Raymond A.; Gazonas, George A.] USA, Res Lab, Weap & Mat Res Directorate, Attn RDRL WMM B, Aberdeen Proving Ground, MD 21005 USA. RP Wildman, RA (reprint author), USA, Res Lab, Weap & Mat Res Directorate, Attn RDRL WMM B, Aberdeen Proving Ground, MD 21005 USA. EM raymond.a.wildman.civ@mail.mil; george.a.gazonas.civ@mail.mil OI Gazonas, George/0000-0002-2715-016X NR 39 TC 1 Z9 1 U1 1 U2 16 PU MATHEMATICAL SCIENCE PUBL PI BERKELEY PA UNIV CALIFORNIA, DEPT MATHEMATICS, BERKELEY, CA 94720-3840 USA SN 1559-3959 J9 J MECH MATER STRUCT JI J. Mech. Mater. Struct. PD OCT PY 2012 VL 7 IS 8-9 BP 765 EP 781 DI 10.2140/jomms.2012.7.765 PG 17 WC Materials Science, Multidisciplinary; Mechanics SC Materials Science; Mechanics GA 080DD UT WOS:000314220500003 ER PT J AU Nezhat, FR Denoble, SM Cho, JE Brown, DN Soto, E Chuang, L Gretz, H Saharia, P AF Nezhat, Farr R. Denoble, Shaghayegh M. Cho, Jennifer E. Brown, Douglas N. Soto, Enrique Chuang, Linus Gretz, Herbert Saharia, Prakash TI Safety and Efficacy of Video Laparoscopic Surgical Debulking of Recurrent Ovarian, Fallopian Tube, and Primary Peritoneal Cancers SO JSLS-JOURNAL OF THE SOCIETY OF LAPAROENDOSCOPIC SURGEONS LA English DT Article DE Operative laparoscopy; recurrent ovarian cancer; fallopian tube cancer; Primary peritoneal cancer; secondary and tertiary cytoreduction ID SECONDARY CYTOREDUCTIVE SURGERY; GYNECOLOGIC-ONCOLOGY-GROUP; EPITHELIAL OVARIAN; TERTIARY CYTOREDUCTION; RESIDUAL DISEASE; STAGE OVARIAN; I OVARIAN; SURVIVAL; CARCINOMA; MANAGEMENT AB Background and Objective: Studies on the role of laparoscopy in secondary or tertiary cytoreduction for recurrent ovarian cancer are limited. Our objective is to describe our preliminary experience with laparoscopic secondary/tertiary cytoreduction in patients with recurrent ovarian, fallopian, and primary peritoneal cancers. Methods: This is a retrospective analysis of a prospective case series. Women with recurrent ovarian, fallopian tube, or primary peritoneal cancers deemed appropriate candidates for laparoscopic debulking by the primary surgeon(s) were recruited. The patients underwent exploratory video laparoscopy, biopsy, and laparoscopic secondary/tertiary cytoreduction between June 1999 and October 2009. Variables analyzed include stage, site of disease, extent of cytoreduction, operative time, blood loss, length of hospital stay, complications, and survival time. Results: Twenty-three patients were recruited. Only one surgery involved conversion to laparotomy. Seventeen (77.3%) of the patients had stage IIIC disease at the time of their initial diagnosis, and 20 (90.9%) had laparotomy for primary debulking. Median blood loss was 75 mL, median operative time 200 min, and median hospital stay 2 d. No intraoperative complications occurred. One patient (4.5%) had postoperative ileus. Eighteen (81.8%) of the patients with recurrent disease were optimally cytoreduced to < 1cm. Overall, 12 patients live no evidence of disease (NED), 6 are alive with disease (AWD), and 4 have died of disease (DOD), over a median follow-up of 14 mo. Median disease-free survival was 71.9 mo. Conclusions: In a well-selected population, laparoscopy is technically feasible and can be utilized to optimally cytoreduce patients with recurrent ovarian, fallopian, or primary peritoneal cancers. C1 [Nezhat, Farr R.] Columbia Univ, Dept Obstet & Gynecol, New York, NY 10019 USA. [Nezhat, Farr R.] St Lukes Roosevelt Hosp, Dept Obstet & Gynecol, New York, NY USA. [Denoble, Shaghayegh M.] Chilton Mem Hosp, Dept Obstet & Gynecol, Pompton Plains, NJ USA. [Cho, Jennifer E.] N Shore Univ Hosp, Dept Obstet & Gynecol, Manhasset, NY USA. [Brown, Douglas N.] Walter Reed Army Med Ctr, Dept Obstet & Gynecol, Wa, DC USA. [Soto, Enrique; Chuang, Linus; Gretz, Herbert] Mt Sinai Med Ctr, Dept Obstet Gynecol & Reprod Sci, New York, NY 10029 USA. [Saharia, Prakash] Winthrop Univ Hosp, Dept Gen Surg, New York, NY USA. RP Nezhat, FR (reprint author), Columbia Univ, Dept Obstet & Gynecol, 1000 10th Ave,10th Floor, New York, NY 10019 USA. EM fnezhat@chpnet.org NR 34 TC 9 Z9 9 U1 0 U2 1 PU SOC LAPAROENDOSCOPIC SURGEONS PI MIAMI PA 7330 SW 62 PL, STE 410, MIAMI, FL 33143-4825 USA SN 1086-8089 J9 JSLS-J SOC LAPAROEND JI JSLS-J. Soc. Laparoendosc. Surg. PD OCT-DEC PY 2012 VL 16 IS 4 BP 511 EP 518 DI 10.4293/108680812X13462882736691 PG 8 WC Surgery SC Surgery GA 079WB UT WOS:000314201800002 PM 23484556 ER EF