FN Thomson Reuters Web of Science™ VR 1.0 PT J AU Sun, J Choi, KK Lee, U AF Sun, Jason Choi, Kwong-Kit Lee, Unchul TI Fabrication of pyramidal corrugated quantum well infrared photodetector focal plane arrays by inductively coupled plasma etching with BCl3/Ar SO JOURNAL OF MICRO-NANOLITHOGRAPHY MEMS AND MOEMS LA English DT Article DE inductively coupled plasma etching; corrugated quantum well infrared photodetector focal plane arrays; pyramidal-shaped etching profile ID SURFACE-INDUCED DAMAGE; INP; SIDEWALL AB We developed an optimized inductively coupled plasma etching process to produce gallium arsenide (GaAs) pyramidal corrugated quantum well infrared photodetector focal plane arrays (C-QWIP FPAs). A statistically designed experiment was performed to optimize the etching parameters. The resulting parameters are discussed in terms of the effect on the etching rate and profile. This process uses a small amount of mask corrosion and the control of the etching mask gap to give a 45 deg to 50 deg V-groove etching profile, which is independent of the crystal orientation of GaAs. In the etching development, scanning electron microscope was used to observe the surface morphology and the pattern profile. In addition, x-ray photoelectron spectroscopy was used to obtain the elemental composition and contamination of the etching surface. It is found that extremely small stoichiometric change and surface damage of the etching surface can be achieved while keeping a relatively high etching rate and similar to 45 deg V-groove etching profile. This etching process is applied to the fabrication of pyramidal C-QWIP FPAs successfully, which are expected to have better performance than the regular prism-shaped C-QWIPs according to electromagnetic modeling. (C) 2012 Society of Photo-Optical Instrumentation Engineers (SPIE). [DOI: 10.1117/1.JMM.11.4.043003] C1 [Sun, Jason; Choi, Kwong-Kit; Lee, Unchul] USA, Res Lab, Adelphi, MD 20783 USA. RP Sun, J (reprint author), USA, Res Lab, Adelphi, MD 20783 USA. EM jason.sun@arl.army.mil RI Choi, Kwong-Kit/K-9205-2013 NR 8 TC 6 Z9 6 U1 2 U2 15 PU SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98225 USA SN 1932-5150 J9 J MICRO-NANOLITH MEM JI J. Micro-Nanolithogr. MEMS MOEMS PD OCT-DEC PY 2012 VL 11 IS 4 AR 043003 DI 10.1117/1.JMM.11.4.043003 PG 4 WC Engineering, Electrical & Electronic; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Optics SC Engineering; Science & Technology - Other Topics; Materials Science; Optics GA 071RH UT WOS:000313611400006 ER PT J AU Peach, ML Zakharov, AV Liu, RF Pugliese, A Tawa, G Wallqvist, A Nicklaus, MC AF Peach, Megan L. Zakharov, Alexey V. Liu, Ruifeng Pugliese, Angelo Tawa, Gregory Wallqvist, Anders Nicklaus, Marc C. TI Computational tools and resources for metabolism-related property predictions. I. Overview of publicly available (free and commercial) databases and software SO FUTURE MEDICINAL CHEMISTRY LA English DT Review ID SMALL-MOLECULE BINDING; COMPARATIVE TOXICOGENOMICS DATABASE; IN-SILICO; DRUG-METABOLISM; XENOBIOTIC METABOLISM; CYTOCHROME-P450 2D6; BIOLOGICAL-ACTIVITY; RS-PREDICTOR; P450 ENZYME; DISCOVERY AB Metabolism has been identified as a defining factor in drug development success or failure because of its impact on many aspects of drug pharmacology, including bioavailability, half-life and toxicity. In this article, we provide an outline and descriptions of the resources for metabolism-related property predictions that are currently either freely or commercially available to the public. These resources include databases with data on, and software for prediction of, several end points: metabolite formation, sites of metabolic transformation, binding to metabolizing enzymes and metabolic stability. We attempt to place each tool in historical context and describe, wherever possible, the data it was based on. For predictions of interactions with metabolizing enzymes, we show a typical set of results for a small test set of compounds. Our aim is to give a clear overview of the areas and aspects of metabolism prediction in which the currently available resources are useful and accurate, and the areas in which they are inadequate or missing entirely. C1 [Zakharov, Alexey V.; Pugliese, Angelo; Nicklaus, Marc C.] NCI, CADD Grp, Biol Chem Lab, Ctr Canc Res,DHHS,Frederich Natl Lab Canc Res,NIH, Frederick, MD 21702 USA. [Peach, Megan L.] SAIC Frederick Inc, CADD Grp, Biol Chem Lab, Frederick Natl Lab Canc Res,Basic Sci Program, Frederick, MD 21702 USA. [Liu, Ruifeng; Tawa, Gregory; Wallqvist, Anders] USA, Med Res & Mat Command, DoD Biotechnol HPC Software Applicat Inst, Frederick, MD 21702 USA. [Pugliese, Angelo] Comp Aided Drug Design Canc Res UK, Beatson Labs, Drug Discovery Programme, Glasgow G61 1BD, Lanark, Scotland. RP Nicklaus, MC (reprint author), NCI, CADD Grp, Biol Chem Lab, Ctr Canc Res,DHHS,Frederich Natl Lab Canc Res,NIH, Bldg 376,376 Boyles Str, Frederick, MD 21702 USA. EM mnl@helix.nih.gov RI pugliese, angelo/C-1729-2008; Nicklaus, Marc/N-4183-2014 FU NIH, Center for Cancer Research; Frederick National Laboratory for Cancer Research, National Institutes of Health [HHSN261200800001E]; US Department of Defense Threat Reduction Agency [TMTI0004_09_BH_T] FX This work was supported in part by the Intramural Research Program of NIH, Center for Cancer Research, in part with Federal finds from the Frederick National Laboratory for Cancer Research, National Institutes of Health, under contract HHSN261200800001E, and in part by the US Department of Defense Threat Reduction Agency Grant TMTI0004_09_BH_T. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. NR 166 TC 9 Z9 9 U1 1 U2 31 PU FUTURE SCI LTD PI LONDON PA UNITED HOUSE, 2 ALBERT PL, LONDON, N3 1QB, ENGLAND SN 1756-8919 J9 FUTURE MED CHEM JI Future Med. Chem. PD OCT PY 2012 VL 4 IS 15 SI SI BP 1907 EP 1932 DI 10.4155/FMC.12.150 PG 26 WC Chemistry, Medicinal SC Pharmacology & Pharmacy GA 055KI UT WOS:000312414500014 PM 23088273 ER PT J AU Griffith, L Bristow, E Jourdan, M AF Griffith, Lawrence Bristow, Elizabeth Jourdan, Mark TI Rapid and Approximate Hydrologic Analysis Using Web-Based Data and Tools SO JOURNAL OF HYDROLOGIC ENGINEERING LA English DT Article DE Remote sensing; Hydrologic modeling; Geographic information systems ID SYSTEM; GIS AB Preliminary site design, emergency response, or engineering operations in remote locations may require a rapid hydrologic analysis to provide decision-support information on a site's suitability for various improvements. This paper describes a procedure for conducting such analyses using widely available Internet-based data and tools. The purpose of this paper is to introduce the reader to the steps necessary to execute a hydrologic analysis remotely. The analysis presented was conducted using programs typically found on any computer or that can be downloaded on short notice from the Internet. Freely available online geospatial data were used to create a database of hydrologic conditions at remotely identified points of interest. These points of interest were compared to actual hydrologic databases for sections of Interstate 25 in New Mexico and State Route M-131 in Michigan. The results of the remote hydrologic analysis correctly identified and analyzed 78% of actual physical locations of culverts for the New Mexico site. Due to increased difficulty of visual identification caused by the density of land cover in a more humid climate, the remote hydrologic analysis technique correctly identified 55% of actual physical locations of culverts for the Michigan site. Potential methods to improve the accuracy of the technique are discussed. DOI: 10.1061/(ASCE)HE.1943-5584.0000561. (C) 2012 American Society of Civil Engineers. C1 [Bristow, Elizabeth] US Mil Acad, West Point, NY 10996 USA. [Griffith, Lawrence] USA, Corps Engineers, Infantry Div 4 25, Ft Richardson, AK USA. [Jourdan, Mark] USA, Corps Engineers, Engineer Res & Dev Ctr, Waterways Expt Stn, Vicksburg, MS 39180 USA. RP Bristow, E (reprint author), US Mil Acad, West Point, NY 10996 USA. EM Elizabeth.bristow@usma.edu NR 13 TC 0 Z9 0 U1 0 U2 6 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 1084-0699 J9 J HYDROL ENG JI J. Hydrol. Eng. PD OCT PY 2012 VL 17 IS 10 BP 1153 EP 1156 DI 10.1061/(ASCE)HE.1943-5584.0000561 PG 4 WC Engineering, Civil; Environmental Sciences; Water Resources SC Engineering; Environmental Sciences & Ecology; Water Resources GA 059NE UT WOS:000312711400008 ER PT J AU Chamberlayne, EP Rakha, HA Bish, DR AF Chamberlayne, Edward P. Rakha, Hesham A. Bish, Douglas R. TI Modeling the capacity drop phenomenon at freeway bottlenecks using the INTEGRATION software SO TRANSPORTATION LETTERS-THE INTERNATIONAL JOURNAL OF TRANSPORTATION RESEARCH LA English DT Article DE INTEGRATION software; traffic simulation; capacity drop; queue discharge flows ID 3-PHASE TRAFFIC THEORY; ON-RAMP BOTTLENECKS; SIGNALIZED INTERSECTIONS; BREAKDOWN PHENOMENON; VEHICLE; BEHAVIOR; CALIBRATION; MANAGEMENT; EMISSIONS; NETWORKS AB Empirical studies have demonstrated that the discharge flow rate at a bottleneck is reduced following the onset of congestion. These flow reductions, also known as capacity drops, are typically measured by comparing the queue discharge flowrate to the maximum pre-queue discharge flow rate. This research demonstrates, through the use of the INTEGRATION microscopic traffic simulation software, that these empirically observed capacity drops can be simulated without enforcing a discontinuity in the steady-state car-following or fundamental diagram. Instead, these capacity drops may be captured by constraining and varying vehicle acceleration levels, which in turn produces the desired macroscopic behavior by introducing gaps between vehicles. The study demonstrates that the INTEGRATION software produces capacity drops at the same level of magnitude as empirically observed. The study then uses the INTEGRATION software to demonstrate the empirically observed stochastic capacity and demonstrates how it is impacted by the level of acceleration that drivers are willing to exert, the lane changing behavior, and the percentage of heavy vehicles in the traffic stream. C1 [Rakha, Hesham A.] Virginia Polytech Inst & State Univ, Dept Civil & Environm Engn 0105, Blacksburg, VA 24061 USA. [Chamberlayne, Edward P.] US Army Corps Engineers, Charleston, SC 29403 USA. [Bish, Douglas R.] Virginia Polytech Inst & State Univ, Grado Dept Ind & Syst Engn 0118, Blacksburg, VA 24061 USA. RP Rakha, HA (reprint author), Virginia Polytech Inst & State Univ, Dept Civil & Environm Engn 0105, Blacksburg, VA 24061 USA. EM edchambe@vt.edu; hrakha@vt.edu; drb1@vt.edu FU Mid-Atlantic University Transportation Center (MAUTC) FX This work has been partially supported by the Mid-Atlantic University Transportation Center (MAUTC). NR 42 TC 5 Z9 5 U1 1 U2 17 PU J ROSS PUBL PI FORT LAUDERDALE PA 5765 N ANDREWS WAY, FORT LAUDERDALE, FL 33309 USA SN 1942-7867 J9 TRANSP LETT JI Transp. Lett. PD OCT PY 2012 VL 4 IS 4 BP 227 EP 242 DI 10.3328/TL.2012.04.04.227-242 PG 16 WC Transportation; Transportation Science & Technology SC Transportation GA 061TW UT WOS:000312872200003 ER PT J AU Wambeke, BW Liu, M Hsiang, SM AF Wambeke, Brad W. Liu, Min Hsiang, Simon M. TI Using Pajek and Centrality Analysis to Identify a Social Network of Construction Trades SO JOURNAL OF CONSTRUCTION ENGINEERING AND MANAGEMENT LA English DT Article DE Social network; Pajek; Degree centrality; Eigenvector centrality; Construction ID BETWEENNESS AB Construction project managers are often faced with the challenge of managing a complex construction process consisting of multiple trades working on a large number of interdependent tasks. A social network is a pattern of ties that exist between different entities (i.e., people, organizations, countries). There is an underlying social network of trades that exists with a construction project and recognizing it can help a management team succeed in this challenging environment. A $50 million project involving 43 trades was studied over a 28-week period. Pajek, a social network analysis program, was used to generate a series of 14 social networks for the trades involved. Both degree and eigenvector centrality were analyzed to reflect the distribution of relationships through the network and to identify the key trades. This research is useful to project managers and is significant as it outlines and illustrates a method of identifying the underlying network and associated key trades of a construction project based on spatial proximity. While this research is based upon an individual case study, the apsects of this research are repeatable. The methods presented in this paper will enable others to develop a social network that is tailored for a specific aspect of a project, ranging from contract development teams to the individual trades using a critical path method (CPM) schedule. DOI:10.1061/(ASCE)CO.1943-7862.0000524. (C) 2012 American Society of Civil Engineers. C1 [Liu, Min] N Carolina State Univ, Dept Civil Construct & Environm Engn, Raleigh, NC 27695 USA. [Wambeke, Brad W.] US Mil Acad, Civil & Mech Engn Dept, West Point, NY 10996 USA. [Hsiang, Simon M.] Texas Tech Univ, Lubbock, TX 79409 USA. RP Liu, M (reprint author), N Carolina State Univ, Dept Civil Construct & Environm Engn, Raleigh, NC 27695 USA. EM bwwambek@ncsu.edu; min_liu@ncsu.edu; simon.hsiang@ttu.edu NR 21 TC 13 Z9 13 U1 10 U2 53 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 0733-9364 EI 1943-7862 J9 J CONSTR ENG M JI J. Constr. Eng. Manage. PD OCT PY 2012 VL 138 IS 10 BP 1192 EP 1201 DI 10.1061/(ASCE)CO.1943-7862.0000524 PG 10 WC Construction & Building Technology; Engineering, Industrial; Engineering, Civil SC Construction & Building Technology; Engineering GA 058YZ UT WOS:000312672500009 ER PT J AU Lee, JH Huang, D Johnson, TH Meurer, S Reid, AA Meldrum, BR AF Lee, Jonah H. Huang, Daisy Johnson, Thomas H. Meurer, Stephen Reid, Alexander A. Meldrum, Bill R. TI Slip-based experimental studies of a vehicle interacting with natural snowy terrain SO JOURNAL OF TERRAMECHANICS LA English DT Article DE Tire; Longitudinal slip; Interfacial forces; Drawbar pull; Traction; Motion resistance; Wheel state; Tire stiffness; Snow depth; Snow strength ID MICROSTRUCTURE AB As longitudinal slip affects vehicle pavement interactions on roads and hard surfaces, so too does it play an important role in interactions between vehicles and soft terrains, including snow. Although many slip-based models have been developed recently for tire-snow interactions (e.g., [1] and references cited therein), these models have only been partially validated, due to a lack of relevant experimental data. This paper presents comprehensive data from tests that were performed using a newly-developed test vehicle traversing natural snowy terrain, over a wide range of values for longitudinal slip, vertical load and torque via an effective accelerate/brake maneuver. Drawbar pull, motion resistance, wheel states and tire stiffness were presented as a function of slip; tire sinkage was obtained using a laser profilometer; strength and depth of snow were found using a snow micropenetrometer. The effects of the rear tire going over snow compacted by the front tire were also studied. The maximum traction force normalized by the vertical load is found to be approximate to 0.47, maximum motion resistance normalized by the vertical load is approximate to 0.4. Comparison of the trend and order-of-magnitude of test results with those from existing slip-based numerical model [1] shows good comparison in motion resistance, tire sinkage, and longitudinal stiffness, but indicates that a better traction model is needed to improve the comparison. (C) 2012 ISTVS. Published by Elsevier Ltd. All rights reserved. C1 [Lee, Jonah H.; Huang, Daisy; Johnson, Thomas H.] Univ Alaska Fairbanks, Fairbanks, AK USA. [Meurer, Stephen] USA, Cold Reg Test Ctr, Ft Greely, AK USA. [Reid, Alexander A.; Meldrum, Bill R.] USA, Tank Automot Res Dev & Engn Ctr, Warren, MI USA. RP Lee, JH (reprint author), Univ Alaska Fairbanks, Fairbanks, AK USA. EM jonah.lee@alaska.edu FU U.S. Army TACOM Life Cycle Command through Mississippi State University [W56HZV-08-C-0236] FX The authors gratefully acknowledge the support of this work by the U.S. Army TACOM Life Cycle Command under Contract No. W56HZV-08-C-0236, through a subcontract with Mississippi State University. This work was performed in part for the Simulation Based Reliability and Safety (SimBRS) research program. Any opinions, findings and conclusions or recommendations expressed in this material are those of the authors and do not necessarily reflect the views of the U.S. Army TACOM Life Cycle Command. NR 16 TC 8 Z9 8 U1 0 U2 13 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0022-4898 J9 J TERRAMECHANICS JI J. Terramech. PD OCT PY 2012 VL 49 IS 5 BP 233 EP 244 DI 10.1016/j.jterra.2012.07.002 PG 12 WC Engineering, Environmental SC Engineering GA 055JM UT WOS:000312412200001 ER PT J AU Fewell, A Lamb, PB Roberts, KK Battafarano, D Owens, NM Harrison, SA AF Fewell, Allyson Lamb, Paul B. Roberts, Katharine K. Battafarano, Daniel Owens, Nicole M. Harrison, Stephen A. TI The Prevalence of Nonalcoholic Fatty Liver Disease (NAFLD) and Nonalcoholic Steatohepatitis (NASH) Among Patients with Psoriasis and Psoriatic Arthritis in a Tertiary Care Dermatology and Rheumatology Clinic SO HEPATOLOGY LA English DT Meeting Abstract CT 63rd Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases (AASLD) CY NOV 09-13, 2012 CL Boston, MA SP Amer Assoc Study Liver Dis C1 [Fewell, Allyson; Lamb, Paul B.; Roberts, Katharine K.; Battafarano, Daniel; Owens, Nicole M.; Harrison, Stephen A.] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. NR 0 TC 1 Z9 1 U1 1 U2 3 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0270-9139 J9 HEPATOLOGY JI Hepatology PD OCT PY 2012 VL 56 SU 1 MA 1503 BP 897A EP 897A PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 035OD UT WOS:000310955603101 ER PT J AU Lomonaco, R Chang, Z Harrison, SA Ortiz-Lopez, C Feldstein, A Orsak, B Louden, C Hardies, J Schenker, S Cusi, K AF Lomonaco, Romina Chang, Zhi Harrison, Stephen A. Ortiz-Lopez, Carolina Feldstein, Ariel Orsak, Beverly Louden, Christopher Hardies, Jean Schenker, Steven Cusi, Kenneth TI Relationship of Cytokeratin-18 with Clinical, Metabolic and Histological Parameters in Patients with Nonalcoholic Steatohepatitis (NASH) SO HEPATOLOGY LA English DT Meeting Abstract CT 63rd Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases (AASLD) CY NOV 09-13, 2012 CL Boston, MA SP Amer Assoc Study Liver Dis C1 [Lomonaco, Romina; Cusi, Kenneth] Univ Florida, Gainesville, FL USA. [Chang, Zhi; Ortiz-Lopez, Carolina; Orsak, Beverly; Louden, Christopher; Hardies, Jean; Schenker, Steven] Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA. [Harrison, Stephen A.] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. [Feldstein, Ariel] Univ Calif San Diego, San Diego, CA 92103 USA. [Cusi, Kenneth] Malcom Randall VAMC, Gainesville, FL USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0270-9139 J9 HEPATOLOGY JI Hepatology PD OCT PY 2012 VL 56 SU 1 MA 1511 BP 900A EP 901A PG 2 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 035OD UT WOS:000310955603109 ER PT J AU Bozue, J Powell, BS Cote, CK Moody, KL Gelhaus, HC Vietri, NJ Rozak, DA AF Bozue, Joel Powell, Bradford S. Cote, Christopher K. Moody, Krishna L. Gelhaus, H. Carl Vietri, Nicholas J. Rozak, David A. TI Disrupting the luxS quorum sensing gene does not significantly affect Bacillus anthracis virulence in mice or guinea pigs SO VIRULENCE LA English DT Article DE Bacillus anthracis; LuxS; anthrax; animal models of infection ID ESCHERICHIA-COLI; SPORE; MACROPHAGES; EXPRESSION; MODEL; COLONIZATION; SPORULATION; METABOLISM; INFECTION; BACTERIA AB Many bacterial species use secreted quorum-sensing autoinducer molecules to regulate cell density- and growth phase-dependent gene expression, including virulence factor production, as sufficient environmental autoinducer concentrations are achieved. Bacillus anthracis, the causative agent of anthrax, contains a functional autoinducer (AI-2) system, which appears to regulate virulence gene expression. To determine if the AI-2 system is necessary for disease, we constructed a LuxS AI-2 synthase-deficient mutant in the virulent Ames strain of B. anthracis. We found that growth of the LuxS-deficient mutant was inhibited and sporulation was delayed when compared with the parental strain. However, spores of the Ames luxS mutant remained fully virulent in both mice and guinea pigs. C1 [Bozue, Joel; Powell, Bradford S.; Cote, Christopher K.; Moody, Krishna L.; Gelhaus, H. Carl; Vietri, Nicholas J.; Rozak, David A.] USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. RP Bozue, J (reprint author), USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. EM joel.a.bozue@us.army.mil FU Defense Threat Reduction Agency JSTO-CBD [1.1A0021_07_RD_B] FX We thank Gabriel Rother for his invaluable technical assistance, Diane Fisher for completing the statistical analysis and Adam Driks and Brad Stiles for their helpful comments and review of this manuscript. The research described herein was sponsored by the Defense Threat Reduction Agency JSTO-CBD project 1.1A0021_07_RD_B. Opinions, interpretations, conclusions and recommendations are those of the authors and are not necessarily endorsed by the United States Army. NR 38 TC 1 Z9 1 U1 0 U2 8 PU LANDES BIOSCIENCE PI AUSTIN PA 1806 RIO GRANDE ST, AUSTIN, TX 78702 USA SN 2150-5594 J9 VIRULENCE JI Virulence PD OCT PY 2012 VL 3 IS 6 BP 504 EP 509 DI 10.4161/viru.21934 PG 6 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 049RE UT WOS:000312000300006 PM 23076278 ER PT J AU Varga, JJ Vigil, A DeShazer, D Waag, DM Felgner, P Goldberg, JB AF Varga, John J. Vigil, Adam DeShazer, David Waag, David M. Felgner, Philip Goldberg, Joanna B. TI Distinct human antibody response to the biological warfare agent Burkholderia mallei SO VIRULENCE LA English DT Article DE Burkholderia mallei; Burkholderia pseudomallei; glanders; melioidosis; protein microarray ID PROTECTIVE IMMUNITY; MICROARRAY ANALYSIS; AEROSOL CHALLENGE; PSEUDOMALLEI; GLANDERS; PROTEIN; MICE; PATHOGENESIS; MELIOIDOSIS; FAILS AB The genetic similarity between Burkholderia mallei (glanders) and Burkholderia pseudomallei (melioidosis) had led to the general assumption that pathogenesis of each bacterium would be similar. In 2000, the first human case of glanders in North America since 1945 was reported in a microbiology laboratory worker. Leveraging the availability of pre-exposure sera for this individual and employing the same well-characterized protein array platform that has been previously used to study a large cohort of melioidosis patients in southeast Asia, we describe the antibody response in a human with glanders. Analysis of 156 peptides present on the array revealed antibodies against 17 peptides with a > 2-fold increase in this infection. Unexpectedly, when the glanders data were compared with a previous data set from B. pseudomallei infections, there were only two highly increased antibodies shared between these two infections. These findings have implications in the diagnosis and treatment of B. mallei and B. pseudomallei infections. C1 [Varga, John J.; Goldberg, Joanna B.] Univ Virginia, Charlottesville, VA 22903 USA. [Vigil, Adam; Felgner, Philip] Univ Calif Irvine, Irvine, CA USA. [Vigil, Adam] ContraFect Corp, Yonkers, NY USA. [DeShazer, David; Waag, David M.] USA, Med Res Inst Infect Dis, Frederick, MD USA. RP Goldberg, JB (reprint author), Univ Virginia, Charlottesville, VA 22903 USA. EM jbg2b@virginia.edu RI Varga, John/I-8130-2012 OI Varga, John/0000-0002-4868-1971 FU National Institutes of Health [R21AI73923, U54AI065359, U01AI061363]; [5T32AI055432] FX This work was supported by the National Institutes of Health (R21AI73923 to J.B.G., U54AI065359 and U01AI061363 to P.F., and J.J.V. was supported by 5T32AI055432 to the University of Virginia). NR 22 TC 3 Z9 3 U1 1 U2 8 PU LANDES BIOSCIENCE PI AUSTIN PA 1806 RIO GRANDE ST, AUSTIN, TX 78702 USA SN 2150-5594 J9 VIRULENCE JI Virulence PD OCT PY 2012 VL 3 IS 6 BP 510 EP 514 DI 10.4161/viru.22056 PG 5 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 049RE UT WOS:000312000300007 PM 23076276 ER PT J AU Pereira, NR Weber, BV Phipps, D Schumer, JW Seely, JF Carroll, JJ VanHoy, JR Slabkowska, K Polasik, M AF Pereira, N. R. Weber, B. V. Phipps, D. Schumer, J. W. Seely, J. F. Carroll, J. J. VanHoy, J. R. Slabkowska, K. Polasik, M. TI similar or equal to 10 eV ionization shift in Ir K alpha(2) from a near-coincident Lu K-edge SO REVIEW OF SCIENTIFIC INSTRUMENTS LA English DT Article; Proceedings Paper CT 19th Topical Conference on High-Temperature Plasma Diagnostics CY MAY 06-10, 2012 CL Monterey, CA ID X-RAY-SPECTRA; IONIZED HEAVY-ATOMS; DIRAC-FOCK METHOD; LINES; BEAM; SPECTROSCOPY; SPECTROMETER; MOLYBDENUM AB Close to an x-ray filter's K-edge the transmission depends strongly on the photon energy. For a few atom pairs, the K-edge of one is only a few tens of eV higher than a K-line energy of another, so that a small change in the line's energy becomes a measurable change in intensity behind such a matching filter. Lutetium's K-edge is similar or equal to 27 eV above iridium's K alpha(2) line, similar or equal to 63.287 keV for cold Ir. A Lu filter reduces this line's intensity by similar or equal to 10 % when it is emitted by a plasma, indicating an ionization shift Delta epsilon similar or equal to 10 +/- 1 eV. (C) 2012 American Institute of Physics. [http://dx.doi.org/10.1063/1.4731739] C1 [Pereira, N. R.] Ecopulse Inc, Springfield, VA 22150 USA. [Weber, B. V.; Phipps, D.; Schumer, J. W.] USN, Res Lab, Washington, DC 20375 USA. [Seely, J. F.] Artep Inc, Ellicott City, MD 21042 USA. [Carroll, J. J.] USA, Res Lab, Adelphi, MD 20873 USA. [VanHoy, J. R.] USN Acad, Annapolis, MD 21402 USA. [Slabkowska, K.; Polasik, M.] Nicholas Copernicus Univ, Fac Chem, PL-87100 Torun, Poland. RP Pereira, NR (reprint author), Ecopulse Inc, POB 528, Springfield, VA 22150 USA. EM ninorpereira@gmail.com RI Schumer, Joseph/D-7591-2013; Slabkowska, katarzyna/O-8760-2015 NR 27 TC 5 Z9 5 U1 0 U2 2 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0034-6748 J9 REV SCI INSTRUM JI Rev. Sci. Instrum. PD OCT PY 2012 VL 83 IS 10 AR 10E110 DI 10.1063/1.4731739 PN 2 PG 3 WC Instruments & Instrumentation; Physics, Applied SC Instruments & Instrumentation; Physics GA 043RB UT WOS:000311562900118 PM 23126932 ER PT J AU Cleland, JA Whitman, JM Houser, JL Wainner, RS Childs, JD AF Cleland, Joshua A. Whitman, Julie M. Houser, Janet L. Wainner, Robert S. Childs, John D. TI Psychometric properties of selected tests in patients with lumbar spinal stenosis SO SPINE JOURNAL LA English DT Article DE Lumbar spinal stenosis; Oswestry Disability Index; Numeric Pain Rating Scale; Patient Specific Functional Scale; Swiss Spinal Stenosis Scale ID LOW-BACK-PAIN; NECK DISABILITY INDEX; CLINICALLY IMPORTANT DIFFERENCE; QUALITY-OF-LIFE; FUNCTIONAL SCALE; PHYSICAL-THERAPY; OUTCOME MEASURES; HEALTH-STATUS; RATING-SCALE; NUMERIC PAIN AB BACKGROUND CONTEXT: The psychometric properties of many outcome tools commonly used with patients with lumbar spinal stenosis have yet to be examined. PURPOSE: Examine the test-retest reliability, responsiveness, and minimum levels of detectable and clinically important differences for several outcome measures in a cohort of patients with lumbar spinal stenosis. STUDY DESIGN/SETTING: Cohort secondary analysis of a randomized clinical trial of patients with lumbar spinal stenosis receiving outpatient physical therapy. PATIENT SAMPLE: Fifty-five patients (mean age, 69.5 years; standard deviation, +/- 7.9 years; 43.1% females) presenting with lumbar spinal stenosis to physical therapy. OUTCOME MEASURES: The Modified Oswestry Disability Index, Modified Swiss Spinal Stenosis Scale (SSS), Patient Specific Functional Scale, and Numeric Pain Rating Scale (NPRS). METHODS: All patients completed the Oswestry Disability Index, SSS, Patient Specific Functional Scale, and NPRS at the baseline examination and at a follow-up. In addition, patients completed a 15-point Global Rating of Change at follow-up, which was used to categorize whether patients experienced clinically meaningful change. Changes in the Oswestry Disability Index, SSS, Patient Specific Functional Scale, and NPRS were then used to assess test-retest reliability, responsiveness, and minimum levels of detectable and clinically important differences. RESULTS: The Oswestry Disability Index was the only outcome measure to exhibit excellent test-retest reliability with an intraclass correlation coefficient of 0.86 (95% confidence interval, 0.63-0.93). All others ranged between fair and moderate. The Oswestry Disability Index, SSS, and Patient Specific Functional Scale exhibited varying levels of responsiveness, each of which was superior to the NPRS. The minimal clinically important difference for the Oswestry Disability Index was five points, the SSS was 0.36 and 0.10 for symptoms subscale and functional subscale, respectively, 1.3 for the Patient Specific Functional Scale, and for the NPRS, 1.25 for back/buttock symptoms and 1.5 for thigh/leg symptoms. CONCLUSIONS: The results of our study indicate that the Oswestry Disability Index, SSS, and Patient Specific Functional Scale possess adequate psychometric properties to be used in the outcome assessment of patients with lumbar spinal stenosis. However, further investigation is needed to validate these findings in other samples of patients with lumbar spinal stenosis and nonspecific low back pain. (C) 2012 Elsevier Inc. All rights reserved. C1 [Cleland, Joshua A.] Franklin Pierce Univ, Dept Phys Therapy, Concord, NH 03301 USA. [Whitman, Julie M.] Evidence Mot LLC, Schertz, TX 78154 USA. [Houser, Janet L.] Regis Univ, Rueckert Hartman Coll Hlth Profess, Denver, CO 80221 USA. [Wainner, Robert S.] Texas State Univ, Dept Phys Therapy, San Marcos, TX 78006 USA. [Childs, John D.] Baylor Univ, USA, Doctoral Program Phys Therapy, Schertz, TX 78154 USA. RP Cleland, JA (reprint author), Franklin Pierce Univ, Dept Phys Therapy, 5 Chenell Dr, Concord, NH 03301 USA. EM joshcleland@comcast.net RI Comba, Valentina/G-6210-2014 FU Orthopedic Section of the American Physical Therapy Association; US Air Force Office of the Surgeon's General FX The Orthopedic Section of the American Physical Therapy Association and the US Air Force Office of the Surgeon's General supported the study. These agencies played no role in the design, conduct, reporting, or decision to submit this manuscript for publication. NR 45 TC 19 Z9 19 U1 0 U2 9 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1529-9430 J9 SPINE J JI Spine Journal PD OCT PY 2012 VL 12 IS 10 BP 921 EP 931 DI 10.1016/j.spinee.2012.05.004 PG 11 WC Clinical Neurology; Orthopedics SC Neurosciences & Neurology; Orthopedics GA 045GY UT WOS:000311684600011 PM 22749295 ER PT J AU Shipley, MA Koehler, JW Kulesh, DA Minogue, TD AF Shipley, Michelle A. Koehler, Jeffrey W. Kulesh, David A. Minogue, Timothy D. TI Comparison of nucleic acid extraction platforms for detection of select biothreat agents for use in clinical resource limited settings SO JOURNAL OF MICROBIOLOGICAL METHODS LA English DT Article DE Nucleic acid extraction comparison; Biothreat diagnostics; Field diagnostics ID REAL-TIME PCR; POLYMERASE CHAIN-REACTION; YERSINIA-PESTIS; ANTHRAX SPORES; DNA; IDENTIFICATION; ASSAY; AMPLIFICATION; INHIBITION; SAMPLES AB High-quality nucleic acids are critical for optimal PCR-based diagnostics and pathogen detection. Rapid sample processing time is important for the earliest administration of therapeutic and containment measures, especially in the case of biothreat agents. In this context, we compared the Fujifilm QuickGene-Mini80 to Qiagen's QIAamp Mini Purification kits for extraction of DNA and RNA for potential use in austere settings. Qiagen (QIAamp) column-based extraction is the currently recommended purification platform by United States Army Medical Research Institute for Infectious Diseases for both DNA and RNA extraction. However, this sample processing system requires dedicated laboratory equipment including a centrifuge. In this study, we investigated the QuickGene-Mini80, which does not require centrifugation, as a suitable platform for nucleic acid extraction for use in resource-limited locations. Quality of the sample extraction was evaluated using pathogen-specific, real-time PCR assays for nucleic acids extracted from viable and gamma-irradiated Bacillus anthracis, Yersinia pestis, vaccinia virus, Venezuelan equine encephalitis virus, or B. anthracis spores in buffer or human whole blood. QuickGene-Mini80 and QIAamp performed similarly for DNA extraction regardless of organism viability. It was noteworthy that gamma-irradiation did not have a significant impact on real-time PCR for organism detection. Comparison with QIAamp showed a less than adequate performance of the Fujifilm instrument for RNA extraction. However, QuickGene-Mini80 remains a viable alternative to QIAamp for DNA extraction for use in remote settings due to extraction quality, time efficiency, reduced instrument requirements. and ease of use. Published by Elsevier B.V. C1 [Shipley, Michelle A.; Koehler, Jeffrey W.; Kulesh, David A.; Minogue, Timothy D.] USA, Diagnost Syst Div, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. RP Minogue, TD (reprint author), USA, Diagnost Syst Div, Med Res Inst Infect Dis, 1425 Porter St, Ft Detrick, MD 21702 USA. EM timothy.minogue@us.army.mil OI Koehler, Jeffrey/0000-0003-3225-6599 FU Defense Threat Reduction Agency (DTRA) through the Joint Science and Technology Office for Chemical and Biological Defense [8.10041_08_RD_B] FX The authors would like to thank Dr. David A. Norwood for providing the B. anthracis, Y. pestis, and VEEV real-time assays. The opinions, interpretations, conclusions, and recommendations contained herein are those of the authors and are not necessarily endorsed by the U.S. Army. This research was supported by the Defense Threat Reduction Agency (DTRA) through the Joint Science and Technology Office for Chemical and Biological Defense, grant # 8.10041_08_RD_B. Author contribution: TDM conceived and designed the experiments, MAS performed the experiments, DAK designed and evaluated the real-time PCR assays, and MAS, JWK, DAK, and TDM analyzed and interpreted the data and wrote the manuscript NR 19 TC 8 Z9 8 U1 0 U2 17 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0167-7012 J9 J MICROBIOL METH JI J. Microbiol. Methods PD OCT PY 2012 VL 91 IS 1 BP 179 EP 183 DI 10.1016/j.mimet.2012.06.008 PG 5 WC Biochemical Research Methods; Microbiology SC Biochemistry & Molecular Biology; Microbiology GA 038LC UT WOS:000311175200030 PM 22750394 ER PT J AU Rafaels, KA Bass, CR Panzer, MB Salzar, RS Woods, WA Feldman, SH Walilko, T Kent, RW Capehart, BP Foster, JB Derkunt, B Toman, A AF Rafaels, Karin A. Bass, Cameron R. 'Dale' Panzer, Matthew B. Salzar, Robert S. Woods, William A. Feldman, Sanford H. Walilko, Tim Kent, Richard W. Capehart, Bruce P. Foster, Jonathan B. Derkunt, Burcu Toman, Amanda TI Brain injury risk from primary blast SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY LA English DT Article DE Primary blast; brain injury; injury risk; ferret ID ADULT-RAT BRAIN; IMPULSE NOISE; HEAD-INJURY; NEURONS; OVERPRESSURE; NEUROTRAUMA; EXPOSURE AB BACKGROUND: Military service members are often exposed to at least one explosive event, and many blast-exposed veterans present with symptoms of traumatic brain injury. However, there is little information on the intensity and duration of blast necessary to cause brain injury. METHODS: Varying intensity shock tube blasts were focused on the head of anesthetized ferrets, whose thorax and abdomen were protected. Injury evaluations included physiologic consequences, gross necropsy, and histologic diagnosis. The resulting apnea, meningeal bleeding, and fatality were analyzed using logistic regressions to determine injury risk functions. RESULTS: Increasing severity of blast exposure demonstrated increasing apnea immediately after the blast. Gross necropsy revealed hemorrhages, frequently near the brain stem, at the highest blast intensities. Apnea, bleeding, and fatality risk functions from blast exposure to the head were determined for peak overpressure and positive-phase duration. The 50% risk of apnea and moderate hemorrhage were similar, whereas the 50% risk of mild hemorrhage was independent of duration and required lower overpressures (144 kPa). Another fatality risk function was determined with existing data for scaled positive-phase durations from 1 millisecond to 20 milliseconds. CONCLUSION: The first primary blast brain injury risk assessments for mild and moderate/severe injuries in a gyrencephalic animal model were determined. The blast level needed to cause a mild/moderate brain injury may be similar to or less than that needed for pulmonary injury. The risk functions can be used in future research for blast brain injury by providing realistic injury risks to guide the design of protection or evaluate injury. (J Trauma Acute Care Surg. 2012;73:895-901. Copyright (C) 2012 by Lippincott Williams & Wilkins) C1 [Woods, William A.] Univ Virginia, Dept Emergency Med, Charlottesville, VA USA. [Rafaels, Karin A.; Salzar, Robert S.; Kent, Richard W.; Foster, Jonathan B.; Derkunt, Burcu] Univ Virginia, Ctr Appl Biomech, Charlottesville, VA USA. [Feldman, Sanford H.] Univ Virginia, Ctr Comparat Med, Charlottesville, VA USA. [Toman, Amanda] Tech Support Working Grp, Arlighton, VA USA. [Bass, Cameron R. 'Dale'; Panzer, Matthew B.] Duke Univ, Dept Biomed Engn, Durham, NC 27706 USA. [Capehart, Bruce P.] Duke Univ, Dept Psychiat & Behav Sci, Durham, NC 27706 USA. [Capehart, Bruce P.] Durham VA Med Ctr, Operat Enduring Freedom Operat Iraqi Freedom Vet, Durham, NC USA. [Capehart, Bruce P.] Durham VA Med Ctr, Mental Hlth Serv Line, Durham, NC USA. [Walilko, Tim] Appl Res Associates, Rocky Mt Div, Littleton, CO USA. RP Rafaels, KA (reprint author), USA, Res Lab, ATTN RDRL SLB W, 328 Hopkins Rd, Aberdeen Proving Ground, MD 21005 USA. EM kar3k@virginia.edu FU TSWG [W91CRB-09-C-0015]; University of Virginia School of Engineering and Applied Sciences; UVA Center for Applied Biomechanics; UVA Center for Comparative Medicine; Duke University Pratt School of Engineering; Department of Biomedical Engineering FX We gratefully acknowledge support from TSWG under contract W91CRB-09-C-0015, the University of Virginia School of Engineering and Applied Sciences, the UVA Center for Applied Biomechanics, the UVA Center for Comparative Medicine for animal support, the Duke University Pratt School of Engineering and the Department of Biomedical Engineering. NR 40 TC 23 Z9 24 U1 3 U2 24 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 2163-0755 J9 J TRAUMA ACUTE CARE JI J. Trauma Acute Care Surg. PD OCT PY 2012 VL 73 IS 4 BP 895 EP 901 DI 10.1097/TA.0b013e31825a760e PG 7 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 029OL UT WOS:000310505100017 PM 22836001 ER PT J AU Kota, KP Benko, JG Mudhasani, R Retterer, C Tran, JP Bavari, S Panchal, RG AF Kota, Krishna P. Benko, Jacqueline G. Mudhasani, Rajini Retterer, Cary Tran, Julie P. Bavari, Sina Panchal, Rekha G. TI High Content Image Based Analysis Identifies Cell Cycle Inhibitors as Regulators of Ebola Virus Infection SO VIRUSES-BASEL LA English DT Article DE ebolavirus; cell cycle; high-content imaging; serum starvation; aphidicolin; nocodazole ID HUMAN-IMMUNODEFICIENCY-VIRUS; REPLICATION; APHIDICOLIN; ARREST; PERTURBATIONS; ALPHA AB Viruses modulate a number of host biological responses including the cell cycle to favor their replication. In this study, we developed a high-content imaging (HCI) assay to measure DNA content and identify different phases of the cell cycle. We then investigated the potential effects of cell cycle arrest on Ebola virus (EBOV) infection. Cells arrested in G1 phase by serum starvation or G1/S phase using aphidicolin or G2/M phase using nocodazole showed much reduced EBOV infection compared to the untreated control. Release of cells from serum starvation or aphidicolin block resulted in a time-dependent increase in the percentage of EBOV infected cells. The effect of EBOV infection on cell cycle progression was found to be cell-type dependent. Infection of asynchronous MCF-10A cells with EBOV resulted in a reduced number of cells in G2/M phase with concomitant increase of cells in G1 phase. However, these effects were not observed in HeLa or A549 cells. Together, our studies suggest that EBOV requires actively proliferating cells for efficient replication. Furthermore, multiplexing of HCI based assays to detect viral infection, cell cycle status and other phenotypic changes in a single cell population will provide useful information during screening campaigns using siRNA and small molecule therapeutics. C1 [Benko, Jacqueline G.; Mudhasani, Rajini; Retterer, Cary; Tran, Julie P.; Bavari, Sina; Panchal, Rekha G.] USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. [Kota, Krishna P.] PerkinElmer, Waltham, MA 02451 USA. RP Panchal, RG (reprint author), USA, Med Res Inst Infect Dis, 1425 Porter St, Ft Detrick, MD 21702 USA. EM krishna.kota@amedd.army.mil; jacqueline.g.benko.ctr@us.army.mil; rajini.mudhasani@amedd.army.mil; cary.retterer@us.army.mil; julie.tran2@us.army.mil; sina.bavari@amedd.army.mil; rekha.panchal@amedd.army.mil FU Joint Science and Technology Office [TMTI_00048_RD_T] FX This project has been funded by Joint Science and Technology Office (TMTI_00048_RD_T). Opinions, interpretations, conclusions, and recommendations are those of the authors and are not necessarily endorsed by the US Army. NR 24 TC 5 Z9 6 U1 2 U2 14 PU MDPI AG PI BASEL PA POSTFACH, CH-4005 BASEL, SWITZERLAND SN 1999-4915 J9 VIRUSES-BASEL JI Viruses-Basel PD OCT PY 2012 VL 4 IS 10 BP 1865 EP 1877 DI 10.3390/v4101865 PG 13 WC Virology SC Virology GA 028YP UT WOS:000310462100002 PM 23202445 ER PT J AU Zumbrun, EE Bloomfield, HA Dye, JM Hunter, TC Dabisch, PA Garza, NL Bramel, NR Baker, RJ Williams, RD Nichols, DK Nalca, A AF Zumbrun, Elizabeth E. Bloomfield, Holly A. Dye, John M. Hunter, Ty C. Dabisch, Paul A. Garza, Nicole L. Bramel, Nicholas R. Baker, Reese J. Williams, Roger D. Nichols, Donald K. Nalca, Aysegul TI A Characterization of Aerosolized Sudan Virus Infection in African Green Monkeys, Cynomolgus Macaques, and Rhesus Macaques SO VIRUSES-BASEL LA English DT Article DE filovirus; ebolavirus; aerosol; primate; animal model ID EBOLA-VIRUS; NONHUMAN-PRIMATES; MARBURG VIRUS; ZAIRE-EBOLAVIRUS; HEMORRHAGIC-FEVER; PROTECTION; VACCINE; FILOVIRUSES; EXPOSURE; TAXONOMY AB Filoviruses are members of the genera Ebolavirus, Marburgvirus, and "Cuevavirus". Because they cause human disease with high lethality and could potentially be used as a bioweapon, these viruses are classified as CDC Category A Bioterrorism Agents. Filoviruses are relatively stable in aerosols, retain virulence after lyophilization, and can be present on contaminated surfaces for extended periods of time. This study explores the characteristics of aerosolized Sudan virus (SUDV) Boniface in non-human primates (NHP) belonging to three different species. Groups of cynomolgus macaques (cyno), rhesus macaques (rhesus), and African green monkeys (AGM) were challenged with target doses of 50 or 500 plaque-forming units (pfu) of aerosolized SUDV. Exposure to either viral dose resulted in increased body temperatures in all three NHP species beginning on days 4-5 post-exposure. Other clinical findings for all three NHP species included leukocytosis, thrombocytopenia, anorexia, dehydration, and lymphadenopathy. Disease in all of the NHPs was severe beginning on day 6 post-exposure, and all animals except one surviving rhesus macaque were euthanized by day 14. Serum alanine transaminase (ALT) and aspartate transaminase (AST) concentrations were elevated during the course of disease in all three species; however, AGMs had significantly higher ALT and AST concentrations than cynos and rhesus. While all three species had detectable viral load by days 3-4 post exposure, Rhesus had lower average peak viral load than cynos or AGMs. Overall, the results indicate that the disease course after exposure to aerosolized SUDV is similar for all three species of NHP. C1 [Zumbrun, Elizabeth E.; Bloomfield, Holly A.; Hunter, Ty C.; Dabisch, Paul A.; Bramel, Nicholas R.; Baker, Reese J.; Williams, Roger D.; Nalca, Aysegul] USA, Ctr Aerobiol Sci, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. [Dye, John M.] USA, Div Virol, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. [Garza, Nicole L.] USA, Div Toxicol, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. [Nichols, Donald K.] USA, Div Pathol, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. RP Nalca, A (reprint author), USA, Ctr Aerobiol Sci, Med Res Inst Infect Dis, 1425 Porter St, Ft Detrick, MD 21702 USA. EM Aysegul.Nalca@us.army.mil OI Zumbrun, Elizabeth/0000-0002-9897-7201 FU Defense Threat Reduction Agency (DTRA) [X.X.0009_06_RD_B]; USAMRIID [10846 (IAA: A120-B11)] FX The authors thank the personnel in the Center for Aerobiological Sciences and the personnel of the Veterinary Medicine. Furthermore, the authors gratefully acknowledge Diana Fisher for her assistance with statistics, and Katheryn Kenyon for editorial revision. This study was supported by an interagency agreement between Defense Threat Reduction Agency (DTRA) and USAMRIID. JSTO-CBD: Project No. X.X.0009_06_RD_B; USAMRIID Plan No. 10846 (IAA: A120-B11). Opinions, interpretations, conclusions, and recommendations are those of the authors and are not necessarily endorsed by the U.S. Army or the Department of Defense. NR 33 TC 12 Z9 13 U1 0 U2 14 PU MDPI AG PI BASEL PA POSTFACH, CH-4005 BASEL, SWITZERLAND SN 1999-4915 J9 VIRUSES-BASEL JI Viruses-Basel PD OCT PY 2012 VL 4 IS 10 BP 2115 EP 2136 DI 10.3390/v4102115 PG 22 WC Virology SC Virology GA 028YP UT WOS:000310462100013 PM 23202456 ER PT J AU Rangsin, R Kana, K Chuenchitra, T Sunantarod, A Meesiri, S Areekul, W Nelson, KE AF Rangsin, R. Kana, K. Chuenchitra, T. Sunantarod, A. Meesiri, S. Areekul, W. Nelson, K. E. TI The recent impact of MSM on the prevalence of HIV-1 infection among young men in Thailand SO JOURNAL OF THE INTERNATIONAL AIDS SOCIETY LA English DT Meeting Abstract C1 [Rangsin, R.; Areekul, W.] Phramongkutklao Coll Med, Bangkok, Thailand. [Kana, K.; Chuenchitra, T.; Meesiri, S.] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Sunantarod, A.] Royal Thai Army Inst Pathol, Bangkok, Thailand. [Nelson, K. E.] Johns Hopkins Bloomberg Sch Publ Hlth, Baltimore, MD USA. EM r_rangsin@yahoo.com NR 0 TC 0 Z9 0 U1 0 U2 0 PU INT AIDS SOCIETY PI GENEVA PA AVENUE DE FRANCE 23, GENEVA, 1202, SWITZERLAND SN 1758-2652 J9 J INT AIDS SOC JI J. Int. AIDS Soc. PD OCT PY 2012 VL 15 SU 3 BP 95 EP 96 PG 2 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 030RQ UT WOS:000310588200184 ER PT J AU Gao, YH Yang, CE Chang, YC Yao, J Yin, S Luo, C Ruffin, P Brantley, C Edwards, E AF Gao, Yaohui Yang, Chia-En Chang, Yunching Yao, Jimmy Yin, Stuart Luo, Claire Ruffin, Paul Brantley, Christina Edwards, Eugene TI Terahertz-radiation-enhanced broadband terahertz generation from large aperture photoconductive antenna SO APPLIED PHYSICS B-LASERS AND OPTICS LA English DT Article ID PULSES AB A technique of enhancing and broadening terahertz (THz) wave radiation from large aperture photoconductive (PC) antenna is presented in this paper. In this technique, the PC antenna is excited by both the optical and previously generated THz pulses by a laser-induced air plasma created in front of PC antenna and an enhanced and broadened THz wave signal is obtained. The theoretical and experimental investigation shows that the superposition is the main mechanism for this enhancement. The technique shown in this paper can be very useful for THz imaging and spectroscopy. C1 [Gao, Yaohui; Yang, Chia-En; Chang, Yunching; Yao, Jimmy; Yin, Stuart] Penn State Univ, Dept Elect Engn, University Pk, PA 16802 USA. [Luo, Claire] Gen Opto Solut LLC, State Coll, PA 16802 USA. [Ruffin, Paul; Brantley, Christina; Edwards, Eugene] USA, Aviat & Missile Res Dev & Engn Ctr, Redstone Arsenal, AL 35898 USA. RP Yin, S (reprint author), Penn State Univ, Dept Elect Engn, University Pk, PA 16802 USA. EM sxy105@psu.edu FU ONR FX Authors greatly acknowledge the partial financial support of this work by an ONR basic research program. The views and opinions of its authors do not necessarily state or reflect those of the US Government or any agency thereof. Reference to any specific commercial product, process, or service by trade name, trademark, manufacturer, or otherwise does not necessarily constitute or imply its endorsement, recommendation, or favoring by the US Government or any agency thereof. NR 11 TC 1 Z9 1 U1 0 U2 17 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0946-2171 J9 APPL PHYS B-LASERS O JI Appl. Phys. B-Lasers Opt. PD OCT PY 2012 VL 109 IS 1 BP 133 EP 136 DI 10.1007/s00340-012-5116-4 PG 4 WC Optics; Physics, Applied SC Optics; Physics GA 032UD UT WOS:000310743700020 ER PT J AU Britzke, ER Loeb, SC Romanek, CS Hobson, KA Vonhof, MJ AF Britzke, E. R. Loeb, S. C. Romanek, C. S. Hobson, K. A. Vonhof, M. J. TI Variation in catchment areas of Indiana bat (Myotis sodalis) hibernacula inferred from stable hydrogen (delta H-2) isotope analysis SO CANADIAN JOURNAL OF ZOOLOGY LA English DT Article DE catchment area; deuterium; hibernacula; Indiana bat; Myotis sodalis; migration; stable isotope analysis ID WHITE-NOSE SYNDROME; PLECOTUS-AURITUS; POPULATION-SIZE; SWARMING SITES; ANIMAL MIGRATION; OXYGEN ISOTOPES; HOST MIGRATION; NATTERERS BATS; NORTH-AMERICA; UNITED-STATES AB Understanding seasonal movements of bats is important for effective conservation efforts. Although female Indiana bats (Myotis sodalis Miller and Allen, 1928) have been documented to migrate >500 km, knowledge of their migratory patterns is still extremely limited. We used the relationship between latitude and stable hydrogen isotope ratio in bat hair (delta H-2(hair)) to estimate the north south extent of the summer range (catchment area) of bats hibernating in 14 Indiana bat hibernacula in eight states throughout its range. Range of delta H-2(hair) values varied substantially among hibernacula, suggesting large differences among sites in the north south distance travelled by bats between summer and winter habitats. In particular, hibernacula in the southern portion of the range had greater catchment areas than those in the central and northern portions of the range. Variability in movement distances among sites was not associated with the number of hair samples analyzed or colony size. Significant year-to-year variation (2007-2008 to 2008-2009) in the distribution of delta H-2(hair) for two sites in Tennessee was observed. Currently, hibernacula considered important for species conservation are largely determined by population size, but our results suggest that migratory diversity should also be considered. C1 [Britzke, E. R.] USA, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. [Loeb, S. C.] Clemson Univ, US Forest Serv, So Res Stn, Clemson, SC 29634 USA. [Romanek, C. S.] Univ Kentucky, Dept Earth & Environm Sci, Lexington, KY 40506 USA. [Hobson, K. A.] Environm Canada, Saskatoon, SK S7N 3H5, Canada. [Vonhof, M. J.] Western Michigan Univ, Dept Biol Sci, Kalamazoo, MI 49008 USA. [Vonhof, M. J.] Western Michigan Univ, Environm Studies Program, Kalamazoo, MI 49008 USA. RP Britzke, ER (reprint author), USA, Engineer Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM Eric.R.Britzke@usace.army.mil FU US Fish and Wildlife Service; New York State Department of Environmental Conservation; New Jersey Division of Fish and Wildlife; Tennessee Wildlife Resources Agency; Bat Conservation International FX Funding for this project was provided by the US Fish and Wildlife Service, New York State Department of Environmental Conservation, New Jersey Division of Fish and Wildlife, Tennessee Wildlife Resources Agency, and Bat Conservation International. Numerous researchers assisted with collection of samples, including T. Carter, R. Clawson, M. Craddock, R. Currie, A. Hicks, and C. Stihler, NR 53 TC 7 Z9 7 U1 5 U2 38 PU CANADIAN SCIENCE PUBLISHING, NRC RESEARCH PRESS PI OTTAWA PA 65 AURIGA DR, SUITE 203, OTTAWA, ON K2E 7W6, CANADA SN 0008-4301 EI 1480-3283 J9 CAN J ZOOL JI Can. J. Zool. PD OCT PY 2012 VL 90 IS 10 BP 1243 EP 1250 DI 10.1139/Z2012-093 PG 8 WC Zoology SC Zoology GA 034GC UT WOS:000310859700005 ER PT J AU Pereira, NR Weber, BV Phipps, DG Schumer, JW Seely, JF Carroll, JJ Vanhoy, JR Slabkowska, K Polasik, M AF Pereira, N. R. Weber, B. V. Phipps, D. G. Schumer, J. W. Seely, J. F. Carroll, J. J. Vanhoy, J. R. Slabkowska, K. Polasik, M. TI Near-coincident K-line and K-edge energies as ionization diagnostics for some high atomic number plasmas SO PHYSICS OF PLASMAS LA English DT Article ID X-RAY-SPECTRA; IONIZED HEAVY-ATOMS; DIRAC-FOCK METHOD; ROD-PINCH DIODE; HIGH-RESOLUTION; SPECTROSCOPY; BEAM; SPECTROMETER; MOLYBDENUM AB For some high atomic number atoms, the energy of the K-edge is tens of eVs higher than the K-line energy of another atom, so that a few eV increase in the line's energy results in a decreasing transmission of the x-ray through a filter of the matching material. The transmission of cold iridium's similar or equal to 63: 287 keV K alpha(2) line through a lutetium filter is 7% lower when emitted by ionized iridium, consistent with an energy increase of Delta epsilon similar or equal to 10 +/- 1 eV associated with the ionization. Likewise, the transmission of the K beta(1) line of ytterbium through a near-coincident K-edge filter changes depending on plasma parameters that should affect the ionization. Systematic exploration of filter-line pairs like these could become a unique tool for diagnostics of suitable high energy density plasmas. (C) 2012 American Institute of Physics. [http://dx.doi.org/10.1063/1.4759497] C1 [Pereira, N. R.] Ecopulse Inc, Springfield, VA 22150 USA. [Weber, B. V.; Phipps, D. G.; Schumer, J. W.] USN, Res Lab, Washington, DC 20375 USA. [Seely, J. F.] Artep Inc, Ellicott City, MD 21042 USA. [Carroll, J. J.] USA, Res Lab, Adelphi, MD 20873 USA. [Vanhoy, J. R.] USN Acad, Annapolis, MD 21402 USA. [Slabkowska, K.; Polasik, M.] Nicholas Copernicus Univ, Fac Chem, PL-87100 Torun, Poland. RP Pereira, NR (reprint author), Ecopulse Inc, POB 528, Springfield, VA 22150 USA. EM ninorpereira-@-gmail.com RI Schumer, Joseph/D-7591-2013; Slabkowska, katarzyna/O-8760-2015 FU DTRA through ARL [W911QX09D0016]; DTRA's Basic Research Sciences [MIPR 08-2468, MIPR 09-2156]; NRL; Polish National Science Centre [2011/01/D/ST2/01286] FX Particular thanks are due to Professor W. Johnson who performed the atomic physics computation included here. We also thank Mr. J. Glover (NIST) for his timely information on K-edge measurements with synchrotrons, Dr. V. Jacobs for comments on the ionization shift of iron, and an anonymous referee for many comments that helped to improve the paper. This work was supported by DTRA through ARL Contract No. W911QX09D0016 to Ecopulse, DTRA's Basic Research Sciences MIPR 08-2468, and MIPR 09-2156 with NRL, and the Polish National Science Centre under Grant No. 2011/01/D/ST2/01286. NR 43 TC 8 Z9 8 U1 0 U2 2 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 1070-664X J9 PHYS PLASMAS JI Phys. Plasmas PD OCT PY 2012 VL 19 IS 10 AR 102705 DI 10.1063/1.4759497 PG 11 WC Physics, Fluids & Plasmas SC Physics GA 030VE UT WOS:000310597400042 ER PT J AU Lujan, SA Williams, JS Pursell, ZF Abdulovic-Cui, AA Clark, AB McElhinny, SAN Kunkel, TA AF Lujan, Scott A. Williams, Jessica S. Pursell, Zachary F. Abdulovic-Cui, Amy A. Clark, Alan B. McElhinny, Stephanie A. Nick Kunkel, Thomas A. TI Mismatch Repair Balances Leading and Lagging Strand DNA Replication Fidelity SO PLOS GENETICS LA English DT Article ID SACCHAROMYCES-CEREVISIAE; POLYMERASE-EPSILON; ESCHERICHIA-COLI; RIBONUCLEOTIDE INCORPORATION; TRINUCLEOTIDE REPEATS; GENOME INSTABILITY; SINGLE-BASE; IN-VITRO; DELTA; ERRORS AB The two DNA strands of the nuclear genome are replicated asymmetrically using three DNA polymerases, alpha, delta, and epsilon. Current evidence suggests that DNA polymerase epsilon (Pol epsilon) is the primary leading strand replicase, whereas Pols alpha and delta primarily perform lagging strand replication. The fact that these polymerases differ in fidelity and error specificity is interesting in light of the fact that the stability of the nuclear genome depends in part on the ability of mismatch repair (MMR) to correct different mismatches generated in different contexts during replication. Here we provide the first comparison, to our knowledge, of the efficiency of MMR of leading and lagging strand replication errors. We first use the strand-biased ribonucleotide incorporation propensity of a Pol epsilon mutator variant to confirm that Pol epsilon is the primary leading strand replicase in Saccharomyces cerevisiae. We then use polymerase-specific error signatures to show that MMR efficiency in vivo strongly depends on the polymerase, the mismatch composition, and the location of the mismatch. An extreme case of variation by location is a T-T mismatch that is refractory to MMR. This mismatch is flanked by an AT-rich triplet repeat sequence that, when interrupted, restores MMR to >95% efficiency. Thus this natural DNA sequence suppresses MMR, placing a nearby base pair at high risk of mutation due to leading strand replication infidelity. We find that, overall, MMR most efficiently corrects the most potentially deleterious errors (indels) and then the most common substitution mismatches. In combination with earlier studies, the results suggest that significant differences exist in the generation and repair of Pol alpha, delta, and epsilon replication errors, but in a generally complementary manner that results in high-fidelity replication of both DNA strands of the yeast nuclear genome. C1 [Lujan, Scott A.; Williams, Jessica S.; Clark, Alan B.; Kunkel, Thomas A.] NIEHS, Mol Genet Lab, Res Triangle Pk, NC 27709 USA. [Lujan, Scott A.; Williams, Jessica S.; Clark, Alan B.; Kunkel, Thomas A.] NIEHS, Struct Biol Lab, Res Triangle Pk, NC 27709 USA. [Pursell, Zachary F.] Tulane Univ, Dept Biochem, New Orleans, LA 70118 USA. [Abdulovic-Cui, Amy A.] Augusta State Univ, Dept Biol, Augusta, GA USA. [McElhinny, Stephanie A. Nick] USA, Res Off, Res Triangle Pk, NC 27709 USA. RP Lujan, SA (reprint author), NIEHS, Mol Genet Lab, Res Triangle Pk, NC 27709 USA. EM kunkel@niehs.nih.gov OI Pursell, Zachary/0000-0001-5871-7192 FU Division of Intramural Research of the National Institutes of Health, National Institute of Environmental Health Sciences [Z01 ES065089] FX This work was supported by Project Z01 ES065089 to TAK, from the Division of Intramural Research of the National Institutes of Health, National Institute of Environmental Health Sciences. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 56 TC 32 Z9 32 U1 0 U2 13 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1553-7404 J9 PLOS GENET JI PLoS Genet. PD OCT PY 2012 VL 8 IS 10 AR e1003016 DI 10.1371/journal.pgen.1003016 PG 9 WC Genetics & Heredity SC Genetics & Heredity GA 029WR UT WOS:000310528400038 PM 23071460 ER PT J AU Collins, CE Narayanan, S Dall'Era, M Dennis, G Oglesby, A McGuire, MB Pappu, R Molta, CT Keenan, G AF Collins, Christopher E. Narayanan, Siva Dall'Era, Maria Dennis, Greg Oglesby, Alan McGuire, Mark B. Pappu, Ramesh Molta, Charles T. Keenan, Greg TI Outcomes Associated with Belimumab in Black/African American Patients with Systemic Lupus Erythematous in Clinical Practice Settings in the United States SO ARTHRITIS AND RHEUMATISM LA English DT Meeting Abstract CT Annual Scientific Meeting of the American-College-of-Rheumatology (ACR) and Association-of-Rheumatology-Health-Professionals (ARHP) CY NOV 09-14, 2012 CL Washington, DC SP Amer Coll Rheumatol (ACR), Assoc Rheumatol Hlth Profess (ARHP) C1 [Collins, Christopher E.] Washington Hosp Ctr, Washington, DC USA. [Narayanan, Siva; Dennis, Greg; Keenan, Greg] Human Genome Sci Inc, Rockville, MD USA. [Dall'Era, Maria] Univ Calif San Francisco, San Francisco, CA 94143 USA. [Oglesby, Alan] GlaxoSmithKline, Res Triangle Pk, NC USA. [McGuire, Mark B.] Med Data Analyt, Parsippany, NJ USA. [Pappu, Ramesh; Molta, Charles T.] USA, GlaxoSmithKline, Philadelphia, PA USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0004-3591 J9 ARTHRITIS RHEUM-US JI Arthritis Rheum. PD OCT PY 2012 VL 64 IS 10 SU S MA 2617 BP S1109 EP S1109 PG 1 WC Rheumatology SC Rheumatology GA 019OD UT WOS:000309748306127 ER PT J AU del Rincon, I Haas, RW O'Leary, DH Polak, JF Battafarano, DF Escalante, A AF del Rincon, Inmaculada Haas, Roy W. O'Leary, Daniel H. Polak, Joseph F. Battafarano, Daniel F. Escalante, Agustin TI Serum Cytokines Associated with Carotid Atherosclerosis in Rheumatoid Arthritis. SO ARTHRITIS AND RHEUMATISM LA English DT Meeting Abstract CT Annual Scientific Meeting of the American-College-of-Rheumatology (ACR) and Association-of-Rheumatology-Health-Professionals (ARHP) CY NOV 09-14, 2012 CL Washington, DC SP Amer Coll Rheumatol (ACR), Assoc Rheumatol Hlth Profess (ARHP) C1 [del Rincon, Inmaculada; Haas, Roy W.; Escalante, Agustin] Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA. [O'Leary, Daniel H.; Polak, Joseph F.] Tufts Univ, Boston, MA 02111 USA. [Battafarano, Daniel F.] Brooke Army Med Ctr, San Antonio, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0004-3591 J9 ARTHRITIS RHEUM-US JI Arthritis Rheum. PD OCT PY 2012 VL 64 IS 10 SU S MA 1269 BP S542 EP S542 PG 1 WC Rheumatology SC Rheumatology GA 019OD UT WOS:000309748302344 ER PT J AU Escalante, A Haas, RW Battafarano, DF Del Rincon, I AF Escalante, Agustin Haas, Roy W. Battafarano, Daniel F. Del Rincon, Inmaculada TI Prediction of Mortality in Rheumatoid Arthritis Using a Serum Cytokine Profile SO ARTHRITIS AND RHEUMATISM LA English DT Meeting Abstract CT Annual Scientific Meeting of the American-College-of-Rheumatology (ACR) and Association-of-Rheumatology-Health-Professionals (ARHP) CY NOV 09-14, 2012 CL Washington, DC SP Amer Coll Rheumatol (ACR), Assoc Rheumatol Hlth Profess (ARHP) C1 [Escalante, Agustin; Haas, Roy W.; Del Rincon, Inmaculada] Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA. [Battafarano, Daniel F.] Brooke Army Med Ctr, San Antonio, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0004-3591 J9 ARTHRITIS RHEUM-US JI Arthritis Rheum. PD OCT PY 2012 VL 64 IS 10 SU S MA 87 BP S39 EP S39 PG 1 WC Rheumatology SC Rheumatology GA 019OD UT WOS:000309748300088 ER PT J AU Restrepo, JF del Rincon, I Haas, RW Battafarano, DF Escalante, A AF Restrepo, Jose Felix del Rincon, Inmaculada Haas, Roy W. Battafarano, Daniel F. Escalante, Agustin TI Joint Damage Progression in Rheumatoid Arthritis: Role of the HLA-DRB1 Shared Epitope and Anti-CCP. SO ARTHRITIS AND RHEUMATISM LA English DT Meeting Abstract CT Annual Scientific Meeting of the American-College-of-Rheumatology (ACR) and Association-of-Rheumatology-Health-Professionals (ARHP) CY NOV 09-14, 2012 CL Washington, DC SP Amer Coll Rheumatol (ACR), Assoc Rheumatol Hlth Profess (ARHP) C1 [Restrepo, Jose Felix; del Rincon, Inmaculada; Haas, Roy W.; Escalante, Agustin] Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA. [Battafarano, Daniel F.] Brooke Army Med Ctr, San Antonio, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0004-3591 J9 ARTHRITIS RHEUM-US JI Arthritis Rheum. PD OCT PY 2012 VL 64 IS 10 SU S MA 2114 BP S894 EP S894 PG 1 WC Rheumatology SC Rheumatology GA 019OD UT WOS:000309748305034 ER PT J AU Restrepo, JF del Rincon, I Haas, R Battafarano, DF Escalante, A AF Restrepo, Jose Felix del Rincon, Inmaculada Haas, Roy Battafarano, Daniel F. Escalante, Agustin TI The Serum Cytokine Profile of Interstitial Lung Disease in Rheumatoid Arthritis SO ARTHRITIS AND RHEUMATISM LA English DT Meeting Abstract CT Annual Scientific Meeting of the American-College-of-Rheumatology (ACR) and Association-of-Rheumatology-Health-Professionals (ARHP) CY NOV 09-14, 2012 CL Washington, DC SP Amer Coll Rheumatol (ACR), Assoc Rheumatol Hlth Profess (ARHP) C1 [Restrepo, Jose Felix; Escalante, Agustin] Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA. [del Rincon, Inmaculada] Univ Texas San Antonio, Hlth Sci Ctr, San Antonio, TX USA. [Battafarano, Daniel F.] Brooke Army Med Ctr, San Antonio, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0004-3591 J9 ARTHRITIS RHEUM-US JI Arthritis Rheum. PD OCT PY 2012 VL 64 IS 10 SU S MA 1213 BP S518 EP S519 PG 2 WC Rheumatology SC Rheumatology GA 019OD UT WOS:000309748302288 ER PT J AU Fox, CB Baldwin, SL Vedvick, TS Angov, E Reed, SG AF Fox, Christopher B. Baldwin, Susan L. Vedvick, Thomas S. Angov, Evelina Reed, Steven G. TI Effects on Immunogenicity by Formulations of Emulsion-Based Adjuvants for Malaria Vaccines SO CLINICAL AND VACCINE IMMUNOLOGY LA English DT Article ID CANDIDATE; RESPONSES; DELIVERY; ENHANCE; CELLS; TRIAL; MICE AB New malaria vaccines are urgently needed to improve vaccine protective efficacy. PfCelTOS is a recombinant malaria vaccine antigen that has shown protective efficacy in a small-animal challenge model when combined with a water-in-oil emulsion adjuvant (Montanide ISA 720). In this report, we show that PfCelTOS vaccines containing GLA-SE (a stable oil-in-water emulsion combined with a Toll-like receptor 4 [TLR4] agonist) elicit strong Th1-type immune responses in BALB/c mice. These responses include higher antigen-specific IgG2a antibody titers and more gamma interferon (IFN-gamma) production than those seen with a PfCelTOS vaccine containing Montanide ISA 720. Furthermore, reducing the emulsion dose from 2% to 1% or 0.5% (vol/vol) squalene in GLA-SE did not compromise immunogenicity. Emulsion dose titration in the absence of formulated GLA caused some reduction in humoral and cellular immune responses compared to those with the 2% squalene emulsion dose. C1 [Fox, Christopher B.; Baldwin, Susan L.; Vedvick, Thomas S.; Reed, Steven G.] Infect Dis Res Inst, Seattle, WA USA. [Angov, Evelina] Walter Reed Army Inst Res, US Mil Malaria Res Program, Malaria Vaccine Branch, Silver Spring, MD USA. RP Fox, CB (reprint author), Infect Dis Res Inst, Seattle, WA USA. EM cfox@idri.org OI Fox, Christopher/0000-0002-4644-2619 FU Bill and Melinda Gates Foundation [42387] FX This research was supported in part by grant 42387 from the Bill and Melinda Gates Foundation. NR 29 TC 22 Z9 22 U1 1 U2 11 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 1556-6811 J9 CLIN VACCINE IMMUNOL JI Clin. Vaccine Immunol. PD OCT PY 2012 VL 19 IS 10 BP 1633 EP 1640 DI 10.1128/CVI.00235-12 PG 8 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 016TE UT WOS:000309541600011 PM 22896687 ER PT J AU Reisner, AT Chen, LY Reifman, J AF Reisner, Andrew T. Chen, Liangyou Reifman, Jaques TI The association between vital signs and major hemorrhagic injury is significantly improved after controlling for sources of measurement variability SO JOURNAL OF CRITICAL CARE LA English DT Article DE Vital signs; Decision support systems; Clinical; Hemorrhage; Data interpretation; Statistical; Emergency care; Prehospital; Trauma ID MEDICAL EMERGENCY TEAM; INTENSIVE-CARE-UNIT; TRAUMA PATIENTS; BLOOD-PRESSURE; PREHOSPITAL HYPOTENSION; RESPIRATORY RATE; SHOCK INDEX; HEART-RATE; MORTALITY; TRIAGE AB Purpose: Measurement error and transient variability affect vital signs. These issues are inconsistently considered in published reports and clinical practice. We investigated the association between major hemorrhagic injury and vital signs, successively applying analytic techniques that excluded unreliable measurements, reduced transient variation, and then controlled for ambiguity in individual vital signs through multivariate analysis. Methods: Vital sign data from 671 adult prehospital trauma patients were analyzed retrospectively. Computer algorithms were used to identify and exclude unreliable data and to apply time averaging. An ensemble classifier was developed and tested by cross-validation. Primary outcome was hemorrhagic injury plus red cell transfusion. Areas under receiver operating characteristic curves (ROC AUCs) were compared by the test of DeLong et al. Results: Of initial vital signs, systolic blood pressure (BP) had the highest ROC AUC of 0.71 (95% confidence interval, 0.64-0.78). The ROC AUCs improved after excluding unreliable data, significantly for heart rate and respiratory rate but not significantly for BP. Time averaging to reduce temporal variability further increased AUCs, significantly for BP and not significantly for heart rate and respiratory rate. The ensemble classifier yielded a final ROC AUC of 0.84 (95% confidence interval, 0.80-0.89) in cross-validation. Conclusions: Techniques to reduce variability in vital sign data can lead to significantly improved diagnostic performance. Failure to consider such variability could significantly reduce clinical effectiveness or confound research investigations. (C) 2012 Elsevier Inc. All rights reserved. C1 [Reisner, Andrew T.; Chen, Liangyou; Reifman, Jaques] USA, Med Res & Mat Command USAMRMC, TATRC, ATTN MCMR TT, Ft Detrick, MD 21702 USA. [Reisner, Andrew T.] Massachusetts Gen Hosp, Dept Emergency Med, Boston, MA 02114 USA. RP Reisner, AT (reprint author), USA, Med Res & Mat Command USAMRMC, TATRC, ATTN MCMR TT, 504 Scott St, Ft Detrick, MD 21702 USA. EM areisner@partners.org; lchen@bioanalysis.org; jaques.reifman@us.army.mil FU US Army Medical Research and Materiel Command, Fort Detrick, MD; Masimo Corp. FX This work was funded by the Combat Casualty Care Research Area Directorate of the US Army Medical Research and Materiel Command, Fort Detrick, MD.; Dr Andrew Reisner participated in a customer advisory meeting for General Electric Healthcare in 2008 and has received speaking fees from Masimo Corp. Dr Reisner is a coinvestigator on a US National Institutes of Health Bioengineering Research Partnership that includes Philips Healthcare. NR 51 TC 1 Z9 1 U1 0 U2 4 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0883-9441 J9 J CRIT CARE JI J. Crit. Care PD OCT PY 2012 VL 27 IS 5 AR 533.e1 DI 10.1016/j.jcrc.2012.01.006 PG 10 WC Critical Care Medicine SC General & Internal Medicine GA 025PP UT WOS:000310204300044 PM 22421006 ER PT J AU Cote, CK Kaatz, L Reinhardt, J Bozue, J Tobery, SA Bassett, AD Sanz, P Darnell, SC Alem, F O'Brien, AD Welkos, SL AF Cote, C. K. Kaatz, L. Reinhardt, J. Bozue, J. Tobery, S. A. Bassett, A. D. Sanz, P. Darnell, S. C. Alem, F. O'Brien, A. D. Welkos, S. L. TI Characterization of a multi-component anthrax vaccine designed to target the initial stages of infection as well as toxaemia SO JOURNAL OF MEDICAL MICROBIOLOGY LA English DT Article ID BACILLUS-ANTHRACIS; PROTECTIVE ANTIGEN; INHALATIONAL ANTHRAX; MOUSE MODEL; IMMUNODOMINANT PROTEIN; SPORE OPSONIZATION; SUBOPTIMAL AMOUNTS; AEROSOL CHALLENGE; CYTOKINE RESPONSE; FULLY VIRULENT AB Current vaccine approaches to combat anthrax are effective; however, they target only a single protein [the protective antigen (PA) toxin component] that is produced after spore germination. PA production is subsequently increased during later vegetative cell proliferation. Accordingly, several aspects of the vaccine strategy could be improved. The inclusion of spore-specific antigens with PA could potentially induce protection to initial stages of the disease. Moreover, adding other epitopes to the current vaccine strategy will decrease the likelihood of encountering a strain of Bacillus anthracis (emerging or engineered) that is refractory to the vaccine. Adding recombinant spore-surface antigens (e.g. BclA, ExsFA/BxpB and p5303) to PA has been shown to augment protection afforded by the latter using a challenge model employing immunosuppressed mice challenged with spores derived from the attenuated Sterne strain of B. anthracis. This report demonstrated similar augmentation utilizing guinea pigs or mice challenged with spores of the fully virulent Ames strain or a non-toxigenic but encapsulated Delta Ames strain of B. anthracis, respectively. Additionally, it was shown that immune interference did not occur if optimal amounts of antigen were administered. By administering the toxin and spore-based immunogens simultaneously, a significant adjuvant effect was also observed in some cases. Thus, these data further support the inclusion of recombinant spore antigens in next-generation anthrax vaccine strategies. C1 [Cote, C. K.; Kaatz, L.; Reinhardt, J.; Bozue, J.; Tobery, S. A.; Bassett, A. D.; Welkos, S. L.] USA, Bacteriol Div, Med Res Inst Infect Dis, Frederick, MD 21702 USA. [Sanz, P.; Darnell, S. C.; Alem, F.; O'Brien, A. D.] Uniformed Serv Univ Hlth Sci, Dept Microbiol & Immunol, Bethesda, MD 20814 USA. RP Welkos, SL (reprint author), USA, Bacteriol Div, Med Res Inst Infect Dis, 1425 Porter St, Frederick, MD 21702 USA. EM Susan.welkos@us.army.mil FU Defense Threat Reduction Agency JSTO-CBD [1.1A0010-07-RDB, CBM.VAXBT.03.10.RD.004/]; Biological Defense Research Directorate of the Naval Medical Research Center; United States Navy; Middle Atlantic Regional Centers of Excellence [1U54 A157168] FX The authors thank Ms Diana Fisher and Ms Sarah Norris for their expert statistical analyses. The research described herein was sponsored by the Defense Threat Reduction Agency JSTO-CBD plans 1.1A0010-07-RDB and CBM.VAXBT.03.10.RD.004/Medical Research/Material Command Research Plan (SLW) and the Biological Defense Research Directorate of the Naval Medical Research Center, United States Navy and the Middle Atlantic Regional Centers of Excellence (1U54 A157168) (A.D. O'B.). Opinions, interpretations, conclusions and recommendations are those of the authors and are not necessarily endorsed by the US Army or Department of Defense. Research was conducted in compliance with the Animal Welfare Act and other federal statutes and regulations relating to animals and experiments involving animals and adheres to the principles stated in the Guide for the Care and Use of Laboratory Animals, National Research Council, 1996. The facility where this research was conducted is fully accredited by the Association for Assessment and Accreditation of Laboratory Animal Care International. NR 63 TC 15 Z9 15 U1 1 U2 12 PU SOC GENERAL MICROBIOLOGY PI READING PA MARLBOROUGH HOUSE, BASINGSTOKE RD, SPENCERS WOODS, READING RG7 1AG, BERKS, ENGLAND SN 0022-2615 J9 J MED MICROBIOL JI J. Med. Microbiol. PD OCT PY 2012 VL 61 IS 10 BP 1380 EP 1392 DI 10.1099/jmm.0.045393-0 PG 13 WC Microbiology SC Microbiology GA 028HX UT WOS:000310414500006 PM 22767539 ER PT J AU Packnett, ER Gubata, ME Cowan, DN Niebuhr, DW AF Packnett, Elizabeth R. Gubata, Marlene E. Cowan, David N. Niebuhr, David W. TI Temporal Trends in the Epidemiology of Disabilities Related to Posttraumatic Stress Disorder in the US Army and Marine Corps From 2005-2010 SO JOURNAL OF TRAUMATIC STRESS LA English DT Article ID MENTAL-HEALTH PROBLEMS; IRAQ-WAR; DEPLOYMENT LENGTH; U.S. ARMY; AFGHANISTAN; MILITARY; SYMPTOMS; SOLDIERS; PERSONNEL; VETERANS AB Since the start of Operation Iraqi Freedom and Operation Enduring Freedom, over 2 million U.S. military members were deployed to Iraq and Afghanistan. The estimated prevalence of posttraumatic stress disorder (PTSD) among soldiers and Marines returning from combat zones varies from 5%20%; little is known about those individuals whose PTSD renders them unfit for duty. This report describes the rates and correlates of PTSD in soldiers and Marines evaluated for disability. Data for service members who underwent disability evaluation between fiscal years 20052010 were analyzed for trends in disability rates, ratings, retirement, and comorbid disability. PTSD rates varied by age, sex, race, rank, branch of service, and component. Most cases were deployed and were considered combat-related. Over the study period, the rate and severity of disability from PTSD increased substantially. Significant increases in disability from PTSD incidence, rating, and retirement were observed in both services. Other medical conditions, largely musculoskeletal and neurological, were present in the majority of cases indicating many cases also experienced disabling physical injuries. Further research is needed to target interventions accurately for redeploying service members to minimize comorbidity associated with disability from PTSD and facilitate continuation in military service or successful transition to civilian life. C1 [Packnett, Elizabeth R.; Gubata, Marlene E.; Cowan, David N.; Niebuhr, David W.] Walter Reed Army Inst Res, Prevent Med Branch, Silver Spring, MD 20910 USA. [Packnett, Elizabeth R.; Cowan, David N.] Allied Technol Grp Inc, Rockville, MD USA. RP Packnett, ER (reprint author), Walter Reed Army Inst Res, Prevent Med Branch, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM elizabeth.packnett1@us.army.mil NR 41 TC 13 Z9 13 U1 1 U2 7 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0894-9867 J9 J TRAUMA STRESS JI J. Trauma Stress PD OCT PY 2012 VL 25 IS 5 BP 485 EP 493 DI 10.1002/jts.21743 PG 9 WC Psychology, Clinical; Psychiatry SC Psychology; Psychiatry GA 026CV UT WOS:000310251500001 PM 23047545 ER PT J AU Pan, HN Hu, XZ Jacobowitz, DM Chen, C McDonough, J Van Shura, K Lyman, M Marini, AM AF Pan, Hongna Hu, Xian-zhang Jacobowitz, David M. Chen, Cynthia McDonough, John Van Shura, Kerry Lyman, Megan Marini, Ann M. TI Alpha-linolenic acid is a potent neuroprotective agent against soman-induced neuropathology SO NEUROTOXICOLOGY LA English DT Article DE Rat; Alpha-linolenic acid; Neuroprotection; Nerve agent; Soman; Nuclear factor kappa B; Fluorojade C; Cresyl violet; Neurodegeneration; Neuropathology ID POLYUNSATURATED FATTY-ACIDS; FACTOR-KAPPA-B; DDVP MARKEDLY DECREASES; CENTRAL-NERVOUS-SYSTEM; INDUCED SEIZURES; NEURONAL EXCITABILITY; SYNAPTIC-TRANSMISSION; EXCITOTOXIC INJURY; INDUCED-INHIBITION; GABA RELEASE AB Nerve agents are deadly threats to military and civilian populations around the world. Nerve agents cause toxicity to peripheral and central sites through the irreversible inhibition of acetylcholinesterase, the enzyme that metabolizes acetylcholine. Excessive acetylcholine accumulation in synapses results in status epilepticus in the central nervous system. Prolonged status epilepticus leads to brain damage, neurological dysfunction and poor outcome. Anticonvulsants are effective but must be given rapidly following exposure. Because these agents cause mass casualties, effective neuroprotective agents are needed to reduce brain damage and improve cognitive outcome. alpha-Linolenic acid is an omega-3 fatty acid that is found in vegetable products and has no known side effects. alpha-Linolenic acid is neuroprotective against kainic acid-induced brain damage in vivo, but its neuroprotective efficacy against nerve agents is unknown. alpha-Linolenic acid also exerts anti-depressant and anti-inflammatory activities and enhances synaptic plasticity in vivo. These properties make this polyunsaturated fatty acid (PUFA) a potential candidate against nerve agent-induced neuropathology. Here we show that alpha-linolenic acid is neuroprotective against soman-induced neuropathology in either a pretreatment or post-treatment paradigm. We also show that subcutaneous injection of alpha-linolenic acid shows greater neuroprotective efficacy compared with intravenous injection in a brain region-specific manner. Published by Elsevier Inc. C1 [Pan, Hongna; Hu, Xian-zhang; Chen, Cynthia; Marini, Ann M.] Uniformed Serv Univ Hlth Sci, Dept Neurol, Bethesda, MD 20814 USA. [Jacobowitz, David M.] Uniformed Serv Univ Hlth Sci, Dept Anat Physiol & Genet, Bethesda, MD 20814 USA. [McDonough, John; Van Shura, Kerry; Lyman, Megan] USA, Pharmacol Branch, Div Res, Med Res Inst Chem Defense, Aberdeen Proving Ground, MD 21010 USA. [Pan, Hongna; Hu, Xian-zhang; Chen, Cynthia; Marini, Ann M.] Uniformed Serv Univ Hlth Sci, Program Neurosci, Bethesda, MD 20814 USA. RP Marini, AM (reprint author), Uniformed Serv Univ Hlth Sci, Dept Neurol, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA. EM amarini@usuhs.mil FU Defense Thread Reduction Agency-Joint Science and Technology Office, Medical ST Division [1.E0017_07_US_C] FX This work was supported by the Defense Thread Reduction Agency-Joint Science and Technology Office, Medical S&T Division grant number: 1.E0017_07_US_C. NR 60 TC 11 Z9 11 U1 0 U2 7 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0161-813X J9 NEUROTOXICOLOGY JI Neurotoxicology PD OCT PY 2012 VL 33 IS 5 BP 1219 EP 1229 DI 10.1016/j.neuro.2012.07.001 PG 11 WC Neurosciences; Pharmacology & Pharmacy; Toxicology SC Neurosciences & Neurology; Pharmacology & Pharmacy; Toxicology GA 028BA UT WOS:000310396600026 PM 22884490 ER PT J AU Bland, CM Tritsch, AM Bookstaver, DA Sweeney, LB Choi, YU AF Bland, Christopher M. Tritsch, Adam M. Bookstaver, David A. Sweeney, Lori B. Choi, Yong U. TI Pharmacist-directed hypertension and diabetes mellitus medication management in sleeve gastrectomy patients SO PHARMACOTHERAPY LA English DT Meeting Abstract CT Annual Meeting of the American-College-of-Clinical-Pharmacy (ACCP) CY OCT 21-24, 2012 CL Hollywood, FL SP Amer Coll Clin Pharm (ACCP) C1 [Bland, Christopher M.; Tritsch, Adam M.; Bookstaver, David A.; Sweeney, Lori B.; Choi, Yong U.] Eisenhower Army Med Ctr, Ft Gordon, GA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0277-0008 J9 PHARMACOTHERAPY JI Pharmacotherapy PD OCT PY 2012 VL 32 IS 10 MA 307 BP E268 EP E268 PG 1 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA 015NH UT WOS:000309452700307 ER PT J AU Bookstaver, DA Bland, CM Woodberry, MW Mansell, KB AF Bookstaver, David A. Bland, Christopher M. Woodberry, Mitchell W. Mansell, Karon B. TI Correlation of cefpodoxime susceptibility with cephalothin, cefuroxime, and ceftriaxone for urinary tract isolates. SO PHARMACOTHERAPY LA English DT Meeting Abstract CT Annual Meeting of the American-College-of-Clinical-Pharmacy (ACCP) CY OCT 21-24, 2012 CL Hollywood, FL SP Amer Coll Clin Pharm (ACCP) C1 [Bookstaver, David A.; Bland, Christopher M.; Woodberry, Mitchell W.; Mansell, Karon B.] Eisenhower Army Med Ctr, Ft Gordon, GA USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0277-0008 J9 PHARMACOTHERAPY JI Pharmacotherapy PD OCT PY 2012 VL 32 IS 10 MA 126 BP E214 EP E215 PG 2 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA 015NH UT WOS:000309452700127 ER PT J AU Liu, RF Tawa, G Wallqvist, A AF Liu, Ruifeng Tawa, Gregory Wallqvist, Anders TI Locally Weighted Learning Methods for Predicting Dose-Dependent Toxicity with Application to the Human Maximum Recommended Daily Dose SO CHEMICAL RESEARCH IN TOXICOLOGY LA English DT Article ID NEAREST-NEIGHBOR; FINGERPRINTS; INHIBITION; SIMILARITY; MOLECULES AB Toxicological experiments in animals are carried out to determine the type and severity of any potential toxic effect associated with a new lead compound. The collected data are then used to 0 extrapolate the effects on humans and determine initial dose regimens for clinical trials. The underlying assumption is that the severity of the toxic effects in animals is correlated with that in humans. However, there is a general lack of toxic correlations across species. Thus, it is more advantageous to predict the toxicological effects of a compound on humans directly from the human toxicological data of related compounds. However, many popular quantitative structure activity relationship (QSAR) methods that build a single global model by fitting all training data appear inappropriate for predicting toxicological effects of structurally diverse compounds because the observed toxicological effects may originate from very different and mostly unknown molecular mechanisms. In this article, we demonstrate, via application to the human maximum recommended daily dose data that locally weighted learning methods, such as k-nearest neighbors, are well suited for predicting toxicological effects of structurally diverse compounds. We also show that a significant flaw of the k-nearest neighbor method is that it always uses a constant number of nearest neighbors in making prediction for a target compound, irrespective of whether the nearest neighbors are structurally similar enough to the target compound to ensure that they share the same mechanism of action. To remedy this flaw, we proposed and implemented a variable number nearest neighbor method. The advantages of the variable number nearest neighbor method over other QSAR methods include (1) allowing more reliable predictions to be achieved by applying a tighter molecular distance threshold and (2) automatic detection for when a prediction should not be made because the compound is outside the applicable domain. C1 [Liu, Ruifeng; Tawa, Gregory; Wallqvist, Anders] USA, US Dept Def, Biotechnol High Performance Comp Software Applica, Telemed & Adv Technol Res Ctr,Med Res & Mat Comma, Ft Detrick, MD 21702 USA. RP Liu, RF (reprint author), USA, US Dept Def, Biotechnol High Performance Comp Software Applica, Telemed & Adv Technol Res Ctr,Med Res & Mat Comma, Ft Detrick, MD 21702 USA. EM RLiu@bhsai.org OI wallqvist, anders/0000-0002-9775-7469 FU U.S. Department of Defense Threat Reduction Agency [TMTI0004_09_BH_T] FX Funding for this research was provided by U.S. Department of Defense Threat Reduction Agency Grant TMTI0004_09_BH_T. NR 28 TC 6 Z9 6 U1 0 U2 5 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0893-228X J9 CHEM RES TOXICOL JI Chem. Res. Toxicol. PD OCT PY 2012 VL 25 IS 10 BP 2216 EP 2226 DI 10.1021/tx300279f PG 11 WC Chemistry, Medicinal; Chemistry, Multidisciplinary; Toxicology SC Pharmacology & Pharmacy; Chemistry; Toxicology GA 019KR UT WOS:000309739000019 PM 22963722 ER PT J AU Phillips, DJ Blaine, KE Cirignano, LJ Ciampi, G Haegel, NM AF Phillips, David J. Blaine, Kevin E. Cirignano, Leonard J. Ciampi, Guido Haegel, Nancy M. TI Cathodoluminescence and Spatial Variation in Mobility-Lifetime (mu tau) Product in Bulk Doped Thallium Bromide SO IEEE TRANSACTIONS ON NUCLEAR SCIENCE LA English DT Article DE Ambipolar diffusion; cathodoluminescence; mobility-lifetime product; thallium bromide; transport imaging ID RADIATION DETECTORS; CRYSTALS; TLBR; PERFORMANCE AB Nonuniformity in charge transport properties is a limiting factor in energy resolution of radiation detectors. In this paper, we investigate variations in the low temperature ambipolar diffusion length and the mobility-lifetime (mu tau) product in bulk doped TlBr using cathodoluminescence (CL) and transport imaging. One TlBr crystal was doped with sodium (Na), aluminum (Al), and silver (Ag). A second TlBr crystal was doped with copper (Cu), iron (Fe), and zinc (Zn). We report the first low temperature high resolution CL spectroscopy and mapping in bulk doped TlBr, showing spatial variation in recombination luminescence on a scale of similar to 10 mu m. Transport imaging is applied to quantify these variations in TlBr at 5 K. Ambipolar diffusion lengths and mu tau products, dominated by the transport of holes, are mapped across a 40 mu m segment of TlBr at a resolution of 2 mu m. Ambipolar diffusion lengths are found to vary between 4.6 mu m and 11.2 mu m, on a spatial scale comparable to the variation observed in the CL map. C1 [Phillips, David J.; Haegel, Nancy M.] USN, Postgrad Sch, Dept Phys, Monterey, CA 93943 USA. [Blaine, Kevin E.] US Mil Acad, Dept Math, West Point, NY 10996 USA. [Cirignano, Leonard J.; Ciampi, Guido] RMD Inc, Watertown, MA 02472 USA. RP Phillips, DJ (reprint author), USN, Postgrad Sch, Dept Phys, Monterey, CA 93943 USA. EM david.john.phillips@us.army.mil; kevin.blaine@usma.edu; lcirignano@rmdinc.com; gciampi@rmdinc.com; nmhaegel@nps.edu FU DNDO Academic Research Initiative Grant [NSF/ARI 083007] FX This work was supported by the DNDO Academic Research Initiative Grant NSF/ARI 083007. NR 27 TC 3 Z9 3 U1 0 U2 8 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0018-9499 J9 IEEE T NUCL SCI JI IEEE Trans. Nucl. Sci. PD OCT PY 2012 VL 59 IS 5 BP 2608 EP 2613 DI 10.1109/TNS.2012.2212210 PN 3 PG 6 WC Engineering, Electrical & Electronic; Nuclear Science & Technology SC Engineering; Nuclear Science & Technology GA 024XD UT WOS:000310143400032 ER PT J AU Shkuratov, SI Baird, J Talantsev, EF Alberta, EF Hackenberger, WS Stults, AH Altgilbers, LL AF Shkuratov, Sergey I. Baird, Jason Talantsev, Evgueni F. Alberta, Edward F. Hackenberger, Wesley S. Stults, Allen H. Altgilbers, Larry L. TI Miniature 100-kV Explosive-Driven Prime Power Sources Based on Transverse Shock-Wave Depolarization of PZT 95/5 Ferroelectric Ceramics SO IEEE TRANSACTIONS ON PLASMA SCIENCE LA English DT Article DE Explosive pulsed power; primary power sources; shock depolarization of ferroelectrics ID LEAD-ZIRCONATE-TITANATE; X-CUT QUARTZ; DIELECTRIC-BREAKDOWN; BARIUM-TITANATE; COMPRESSION; GENERATOR; SYSTEM AB Our previous efforts were focused on designing, constructing, and investigating miniature shock-wave ferroelectric generators (FEGs) based on Pb(Zr0.52Ti0.48)O-3 poled ferroelectric ceramics (that is widely used in modern technology). In this paper, we extended our efforts by exploring a different type of ferroelectric materials, i.e., Pb(Zr0.95Ti0.05)O-3 (PZT 95/5), for designing miniature autonomous shock-wave FEGs. The performance of autonomous ultrahigh-voltage FEGs based on transverse explosive shock depolarization of poled PZT 95/5 ferroelectric ceramics was studied. As a result of this paper, miniature generators (38 mm in diameter) that are capable of producing output voltage pulses with amplitudes exceeding 120 kV and pulsewidths of 3 mu s were developed. C1 [Shkuratov, Sergey I.; Baird, Jason] Loki Inc, Rolla, MO 65401 USA. [Baird, Jason] Missouri Univ Sci & Technol, Dept Min & Nucl Engn, Rolla, MO 65409 USA. [Talantsev, Evgueni F.] Pulsed Power LLC, Lubbock, TX 79416 USA. [Alberta, Edward F.; Hackenberger, Wesley S.] TRS Technol Inc, State Coll, PA 16801 USA. [Stults, Allen H.] USA, Aviat & Missile Engn Ctr, Huntsville, AL 35807 USA. [Altgilbers, Larry L.] USA, Army Space & Missile Def Command, Army Forces Strateg Command, Huntsville, AL 35807 USA. RP Shkuratov, SI (reprint author), Loki Inc, Rolla, MO 65401 USA. EM shkuratov@lokiconsult.com OI Talantsev, Evgeny/0000-0001-8970-7982 NR 23 TC 3 Z9 3 U1 0 U2 9 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0093-3813 J9 IEEE T PLASMA SCI JI IEEE Trans. Plasma Sci. PD OCT PY 2012 VL 40 IS 10 SI SI BP 2512 EP 2516 DI 10.1109/TPS.2012.2202249 PN 1 PG 5 WC Physics, Fluids & Plasmas SC Physics GA 021EG UT WOS:000309867500028 ER PT J AU Fletcher, SJ Liston, GE Hiemstra, CA Miller, SD AF Fletcher, Steven J. Liston, Glen E. Hiemstra, Christopher A. Miller, Steven D. TI Assimilating MODIS and AMSR-E Snow Observations in a Snow Evolution Model SO JOURNAL OF HYDROMETEOROLOGY LA English DT Article ID LAND-SURFACE MODEL; WATER EQUIVALENT; COVER DATA; SYSTEM; DISTRIBUTIONS; INSTRUMENTS; PRODUCTS; DEPTH AB In this paper four simple computationally inexpensive, direct insertion data assimilation schemes are presented, and evaluated, to assimilate Moderate Resolution Imaging Spectroradiometer (MODIS) snow cover, which is a binary observation, and Advanced Microwave Scanning Radiometer for Earth Observing System (EOS) (AMSR-E) snow water equivalent (SWE) observations, which are at a coarser resolution than MODIS, into a numerical snow evolution model. The four schemes are 1) assimilate MODIS snow cover on its own with an arbitrary 0.01 m added to the model cells if there is a difference in snow cover; 2) iteratively change the model SWE values to match the AMSR-E equivalent value; 3) AMSR-E scheme with MODIS observations constraining which cells can be changed, when both sets of observations are available; and 4) MODIS-only scheme when the AMSR-E observations are not available, otherwise scheme 3. These schemes are used in the winter of 2006/07 over the southeast corner of Colorado and the tri-state area: Wyoming, Colorado. and Nebraska. It is shown that the inclusion of MODIS data enables the model in the north domain to have a 15% improvement in number of days with a less than 10% disagreement with the MODIS observation 24 h later and approximately 5% for the south domain. It is shown that the AMSR-E scheme has more of an impact in the south domain than the north domain. The assimilation results are also compared to station snow-depth data in both domains, where there is up-to-a-factor-of-5 underestimation of snow depth by the assimilation schemes compared with the station data but the snow evolution is fairly consistent. C1 [Fletcher, Steven J.; Liston, Glen E.; Miller, Steven D.] Colorado State Univ, Cooperat Inst Res Atmosphere, Ft Collins, CO 80523 USA. [Hiemstra, Christopher A.] US Army Corps Engineers, Cold Reg Res & Engn Lab, Ft Wainwright, AK USA. RP Fletcher, SJ (reprint author), Colorado State Univ, Cooperat Inst Res Atmosphere, 1375 Campus Delivery, Ft Collins, CO 80523 USA. EM fletcher@cira.colostate.edu FU NASA [NNX08AV21G] FX SJF is grateful for the help from Mr. John Forsythe at CIRA in understanding and inverting the different projections that the MODIS and AMSR-E observations come in. We are grateful for the useful reviews of this manuscript by Noah Molotch and the four other anonymous reviewers. This work was supported by the NASA Grant NNX08AV21G. NR 32 TC 8 Z9 9 U1 2 U2 19 PU AMER METEOROLOGICAL SOC PI BOSTON PA 45 BEACON ST, BOSTON, MA 02108-3693 USA SN 1525-755X J9 J HYDROMETEOROL JI J. Hydrometeorol. PD OCT PY 2012 VL 13 IS 5 BP 1475 EP 1492 DI 10.1175/JHM-D-11-082.1 PG 18 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA 023NT UT WOS:000310042400005 ER PT J AU Arendt, PD Apley, DW Chen, W Lamb, D Gorsich, D AF Arendt, Paul D. Apley, Daniel W. Chen, Wei Lamb, David Gorsich, David TI Improving Identifiability in Model Calibration Using Multiple Responses SO JOURNAL OF MECHANICAL DESIGN LA English DT Article DE multiple responses; Gaussian process; model updating; calibration; identifiability; uncertainty quantification; Multiple response emulator ID COMPUTER-SIMULATIONS; UNCERTAINTY; OUTPUT AB In physics-based engineering modeling, the two primary sources of model uncertainty, which account for the differences between computer models and physical experiments, are parameter uncertainty and model discrepancy. Distinguishing the effects of the two sources of uncertainty can be challenging. For situations in which identifiability cannot be achieved using only a single response, we propose to improve identifiability by using multiple responses that share a mutual dependence on a common set of calibration parameters. To that end, we extend the single response modular Bayesian approach for calculating posterior distributions of the calibration parameters and the discrepancy function to multiple responses. Using an engineering example, we demonstrate that including multiple responses can improve identifiability (as measured by posterior standard deviations) by an amount that ranges from minimal to substantial, depending on the characteristics of the specific responses that are combined. [DOI: 10.1115/1.4007573] C1 [Arendt, Paul D.; Chen, Wei] Northwestern Univ, Dept Mech Engn, Evanston, IL 60208 USA. [Apley, Daniel W.] Northwestern Univ, Dept Ind Engn & Management Sci, Evanston, IL 60208 USA. [Lamb, David; Gorsich, David] USA, Tank Automot Res Dev & Engn Ctr, Warren, MI 48397 USA. RP Chen, W (reprint author), Northwestern Univ, Dept Mech Engn, 2145 Sheridan Rd,Room A216, Evanston, IL 60208 USA. EM paularendt2012@u.northwestern.edu; apley@northwestern.edu; weichen@northwestern.edu RI Apley, Daniel/B-7454-2009; Chen, Wei/B-7574-2009 FU National Science Foundation [CMMI-1233403, CMMI-0928320, CMMI-0758557]; U.S. Army Tank-Automotive Research Development and Engineering Center (TARDEC) [W911NF11D0001-0037] FX The grant support from the National Science Foundation (CMMI-1233403, CMMI-0928320 and CMMI-0758557) and the U.S. Army Tank-Automotive Research Development and Engineering Center (TARDEC) (Contract No. W911NF11D0001-0037) is greatly acknowledged. The views expressed are those of the authors and do not necessarily reflect the views of the sponsors. NR 21 TC 14 Z9 14 U1 1 U2 17 PU ASME-AMER SOC MECHANICAL ENG PI NEW YORK PA THREE PARK AVE, NEW YORK, NY 10016-5990 USA SN 1050-0472 J9 J MECH DESIGN JI J. Mech. Des. PD OCT PY 2012 VL 134 IS 10 AR 100909 DI 10.1115/1.4007573 PG 9 WC Engineering, Mechanical SC Engineering GA 018IU UT WOS:000309654400011 ER PT J AU Armistead-Jehle, P Lee, D AF Armistead-Jehle, Patrick Lee, Dongwook TI Response to the Harch Group's "A Phase I Study of Low-Pressure Hyperbaric Oxygen Therapy for Blast-Induced Post-Concussion Syndrome and Post-Traumatic Stress Disorder" SO JOURNAL OF NEUROTRAUMA LA English DT Letter ID VALIDITY TEST-PERFORMANCE; CONTROLLED-TRIALS; INJURY; RECOVERY; VETERANS; IMPACT; SPEED; TESTS; TBI C1 [Armistead-Jehle, Patrick] Munson Army Hlth Ctr, Dept Behav Hlth, Ft Leavenworth, KS 66027 USA. [Lee, Dongwook] Joint Base Lewis McChord, Western Reg Med Command, Washington, DC USA. RP Armistead-Jehle, P (reprint author), Munson Army Hlth Ctr, Dept Behav Hlth, 550 Pope Ave, Ft Leavenworth, KS 66027 USA. EM patrick.jehle@amedd.army.mil NR 28 TC 1 Z9 2 U1 1 U2 3 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 J9 J NEUROTRAUM JI J. Neurotrauma PD OCT PY 2012 VL 29 IS 15 BP 2513 EP 2515 DI 10.1089/neu.2012.2400 PG 3 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA 022NY UT WOS:000309967300009 PM 22568791 ER PT J AU Krueger, CA Masini, BD Wenke, JC Hsu, JR Stinner, DJ AF Krueger, Chad A. Masini, Brendan D. Wenke, Joseph C. Hsu, Joseph R. Stinner, Daniel J. TI Time-Dependent Effects of Chlorhexidine Soaks on Grossly Contaminated Bone SO JOURNAL OF ORTHOPAEDIC TRAUMA LA English DT Article ID POVIDONE-IODINE SOLUTION; EXPLANTED SKULL BONE; FEMORAL-SHAFT; STERILIZATION; REIMPLANTATION; ALLOGRAFTS; FRACTURE; GRAFTS; LAVAGE; FRAGMENT AB Objective: The purpose of this study was to quantify the reduction in the bacterial burden of grossly contaminated bone segments using different chlorhexidine (CHL) solutions. We hypothesized that 4% CHL would be the most efficient decontaminate. Methods: Fifty-four bone segments were harvested from fresh-frozen porcine legs. Each specimen was dropped onto a Mueller-Hinton medium that was inoculated with Staphylococcus aureus (lux). These genetically engineered bacteria emit photons in proportion to their number, allowing for quantification. The segments were retrieved after 5 seconds of exposure. Baseline imaging provided the initial bacterial load. An equal number of specimens were soaked in normal saline (NS), 2% CHL, or 4% CHL. Specimen reimaging was completed at the 5-, 10-, 20-, 30-, and 60-minute marks. Results: The average bacterial count on the bone segments were 2.18 x 107 for NS, 2.31 x 107 for 2% CHL, and 2.00 x 107 for 4% CHL. The percent reduction in bacterial counts at the 5-, 10-, 20-, 30-, and 60-minute marks were NS: 0%, 0%, 0%, 29.84%, 72.23%; 2% CHL: 93.09%, 98.16%, 99.21%, 99.63%, 99.81%; 4% CHL: 94.32%, 97.60%, 99.25%, 99.63%, 99.82%. At all time intervals, there was a significant difference between the 2% CHL and 4% CHL groups compared with the NS group (P, 0.0001) and no difference between the 2% CHL and 4% CHL groups. Conclusions: This study provides new data supporting the use of CHL to decontaminate grossly soiled bone segments. To maximize efficiency and decrease potential untoward effects, the authors recommend 20-minute soaks using 2% CHL for contaminated bone segments. C1 [Krueger, Chad A.; Masini, Brendan D.; Stinner, Daniel J.] Brooke Army Med Ctr, Dept Orthopaed & Rehabil, Ft Sam Houston, TX 78234 USA. [Wenke, Joseph C.; Hsu, Joseph R.] USA, Inst Surg Res, Dept Regenerat Med, Ft Sam Houston, TX 78234 USA. RP Krueger, CA (reprint author), Brooke Army Med Ctr, Dept Orthopaed & Rehabil, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM chad.krueger@amedd.army.mil OI Stinner, Daniel/0000-0002-8981-6262 FU United States Army Institute of Surgical Research FX Supported by the United States Army Institute of Surgical Research. NR 32 TC 1 Z9 1 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0890-5339 J9 J ORTHOP TRAUMA JI J. Orthop. Trauma PD OCT PY 2012 VL 26 IS 10 BP 574 EP 578 DI 10.1097/BOT.0b013e31824a3aad PG 5 WC Orthopedics; Sport Sciences SC Orthopedics; Sport Sciences GA 022LV UT WOS:000309961800011 PM 22473065 ER PT J AU Drozdz, S Hawkins, T AF Drozdz, Susan Hawkins, Todd TI Carbon nanotube-infused zinc coating combines barrier properties with cathodic protection SO MATERIALS PERFORMANCE LA English DT Editorial Material C1 [Drozdz, Susan] USA, Erdc, Washington, DC 20310 USA. RP Drozdz, S (reprint author), USA, Erdc, Washington, DC 20310 USA. EM Susan.A.Drozdz@usace.army.mil; todd@teslanano.com NR 1 TC 0 Z9 0 U1 0 U2 2 PU NATL ASSOC CORROSION ENG PI HOUSTON PA 1440 SOUTH CREEK DRIVE, HOUSTON, TX 77084-4906 USA SN 0094-1492 J9 MATER PERFORMANCE JI Mater. Perform. PD OCT PY 2012 VL 51 IS 10 BP 14 EP 16 PG 3 WC Materials Science, Characterization & Testing SC Materials Science GA 024IL UT WOS:000310102800004 ER PT J AU Fu, R Pattison, J AF Fu, Richard Pattison, James TI Advanced thin conformal Al2O3 films for high aspect ratio mercury cadmium telluride sensors SO OPTICAL ENGINEERING LA English DT Article DE atomic layer deposition; plasma enhanced atomic layer deposition; Al2O3 film; mercury cadmium telluride ID ATOMIC LAYER DEPOSITION; TEMPERATURE AB Mercury cadmium telluride (HgCdTe) processing must be performed at a low temperature in order to reduce Hg depletion. To meet demand, low-temperature plasma enhanced atomic layer deposition (PE-ALD) is an emerging deposition technology for highly conformal thin films. We comparatively studied the effectiveness of low-temperature PE-ALD by measuring the ALD film roughness, thickness, and dielectric values. Conformal deposition was investigated through scanning electron microscopy images of the Al2O3 film deposited onto high aspect ratio features dry-etched into HgCdTe. PE-ALD demonstrated conformal coatings of trenches, pillars and holes in advanced HgCdTe infrared sensor architectures. (C) 2012 Society of Photo-Optical Instrumentation Engineers (SPIE). [ DOI: 10.1117/1.OE.51.10.104003] C1 [Fu, Richard; Pattison, James] USA, Res Lab, Adelphi, MD 20783 USA. RP Fu, R (reprint author), USA, Res Lab, Adelphi, MD 20783 USA. EM richard.x.fu.civ@mail.mil NR 7 TC 7 Z9 11 U1 0 U2 18 PU SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98225 USA SN 0091-3286 J9 OPT ENG JI Opt. Eng. PD OCT PY 2012 VL 51 IS 10 AR 104003 DI 10.1117/1.OE.51.10.104003 PG 4 WC Optics SC Optics GA 021WF UT WOS:000309915400027 ER PT J AU Heiner, JD Bebarta, VS Vamey, SM Bothwell, JD Cronin, AJ AF Heiner, J. D. Bebarta, V. S. Vamey, S. M. Bothwell, J. D. Cronin, A. J. TI Clinical Effects and Antivenom Use for Snake Bite Victims Treated at Three US Hospitals in Afghanistan SO ANNALS OF EMERGENCY MEDICINE LA English DT Meeting Abstract CT Research Forum of the American-College-of-Emergency-Physicians (ACEP) CY OCT 08-09, 2012 CL Denver, CO SP Amer Coll Emergency Phys (ACEP) C1 [Heiner, J. D.] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. Madigan Army Med Ctr, Joint Base Lewis McCord, Tacoma, WA USA. Womack Army Med Ctr, Ft Bragg, NC USA. RI Bebarta, Vikhyat/M-1513-2015; bebarta, vikhyat/K-3476-2015 NR 0 TC 0 Z9 0 U1 0 U2 1 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0196-0644 J9 ANN EMERG MED JI Ann. Emerg. Med. PD OCT PY 2012 VL 60 IS 4 SU S BP S126 EP S126 PG 1 WC Emergency Medicine SC Emergency Medicine GA 018BX UT WOS:000309636100351 ER PT J AU Lairet, JR Bebarta, V Mathis, D Warren, W Lawler, C Lairet, K Muncy, T Boudreau, S Pitotti, R Brock, J King, J AF Lairet, J. R. Bebarta, V Mathis, D. Warren, W. Lawler, C. Lairet, K. Muncy, T. Boudreau, S. Pitotti, R. Brock, J. King, J. TI Comparison of Intraosseous Infusion Rates of Blood Under High Pressure in an Adult Hypovolemic Swine Model In Three Different Limb Sites SO ANNALS OF EMERGENCY MEDICINE LA English DT Meeting Abstract CT Research Forum of the American-College-of-Emergency-Physicians (ACEP) CY OCT 08-09, 2012 CL Denver, CO SP Amer Coll Emergency Phys (ACEP) C1 [Lairet, J. R.] San Antonio Mil Med Ctr, Ft Sam Houston, TX USA. USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. RI Bebarta, Vikhyat/M-1513-2015; bebarta, vikhyat/K-3476-2015 NR 0 TC 3 Z9 3 U1 0 U2 1 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0196-0644 J9 ANN EMERG MED JI Ann. Emerg. Med. PD OCT PY 2012 VL 60 IS 4 SU S BP S75 EP S75 PG 1 WC Emergency Medicine SC Emergency Medicine GA 018BX UT WOS:000309636100207 ER PT J AU Darafsheh, A Walsh, GF Dal Negro, L Astratov, VN AF Darafsheh, Arash Walsh, Gary F. Dal Negro, Luca Astratov, Vasily N. TI Optical super-resolution by high-index liquid-immersed microspheres SO APPLIED PHYSICS LETTERS LA English DT Article ID PHOTONIC NANOJETS; LIGHT; BACKSCATTERING; FUNDAMENTALS; ENHANCEMENT; HYPERLENS; LENSES AB It is experimentally shown that barium titanate glass microspheres with diameters (D) in the range 2-220 mu m and with high refractive index (n similar to 1.9-2.1) can be used for super-resolution imaging of liquid-immersed nanostructures. Using micron-scale microspheres, we demonstrate an ability to discern the shape of a pattern with a minimum feature size of similar to lambda/7, where lambda is the illumination wavelength. For spheres with D > 50 mu m, the discernible feature sizes were found to increase to similar to lambda/4. Detailed data on the resolution, magnification, and field-of-view are presented. This imaging technique can be used in biomedical microscopy, microfluidics, and nanophotonics applications. (C) 2012 American Institute of Physics. [http://dx.doi.org/10.1063/1.4757600] C1 [Darafsheh, Arash; Astratov, Vasily N.] Univ N Carolina, Dept Phys & Opt Sci, Ctr Optoelect & Opt Commun, Charlotte, NC 28223 USA. [Walsh, Gary F.; Dal Negro, Luca] Boston Univ, Photon Ctr, Boston, MA 02215 USA. [Walsh, Gary F.; Dal Negro, Luca] Boston Univ, Dept Elect & Comp Engn, Boston, MA 02215 USA. [Walsh, Gary F.] USA, NSRDEC, Nanomat Sci Team, Natick, MA 01760 USA. RP Darafsheh, A (reprint author), Univ N Carolina, Dept Phys & Opt Sci, Ctr Optoelect & Opt Commun, Charlotte, NC 28223 USA. EM adarafs1@uncc.edu; astratov@uncc.edu RI Astratov, Vasily/D-1089-2012 FU U.S. Army Research Office (ARO) [W911NF-09-1-0450]; National Science Foundation (NSF) [ECCS-0824067]; U.S. Army Natick Soldier Center [W911NF-07-D-001]; SMART Scholarship Program FX The authors thank M.A. Fiddy, I. Vitebskiy, V. Kovanis, and D.M. Whittaker for stimulating discussions, A.D. Davies for sharing high NA microscope objective, and MOSCI Corporation for donating some of the microspheres used in this work. This research was supported by the U.S. Army Research Office (ARO) through Dr. J.T. Prater under Contract No. W911NF-09-1-0450 and the National Science Foundation (NSF) under Grant No. ECCS-0824067. The fabrication work was supported by the U.S. Army Natick Soldier Center under Contract No. W911NF-07-D-001 and the SMART Scholarship Program, and has been approved for public release NSRDEC PAO#U12-307. NR 26 TC 78 Z9 81 U1 11 U2 49 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD OCT 1 PY 2012 VL 101 IS 14 AR 141128 DI 10.1063/1.4757600 PG 4 WC Physics, Applied SC Physics GA 017PS UT WOS:000309603300028 ER PT J AU Maseng, T Landry, R Young, K AF Maseng, Torleiv Landry, Randall Young, Kenneth TI MILITARY COMMUNICATIONS SO IEEE COMMUNICATIONS MAGAZINE LA English DT Editorial Material C1 [Maseng, Torleiv] Norwegian Def Res Estab, Trondheim, Norway. [Maseng, Torleiv] SINTEF, N-7034 Trondheim, Norway. [Maseng, Torleiv] NC3A NATO Res Ctr, The Hague, Netherlands. [Maseng, Torleiv] Lund Univ, S-22100 Lund, Sweden. [Maseng, Torleiv] Norwegian Def Res Estab FFI, Kjeller, Norway. [Maseng, Torleiv] Univ Oslo, N-0316 Oslo, Norway. [Young, Kenneth] Appl Commun Sci, Appl Res Org, Piscataway, NJ USA. [Young, Kenneth] USA, Res Lab, Commun & Networks Collaborat Technol Alliance, Washington, DC USA. [Young, Kenneth] USA, CERDEC, Proact Integrated Link Select Network Robustness, Washington, DC USA. RP Maseng, T (reprint author), Norwegian Def Res Estab, Trondheim, Norway. EM torleiv.maseng@ffi.no; rlandry@mitre.org NR 0 TC 0 Z9 0 U1 0 U2 3 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0163-6804 J9 IEEE COMMUN MAG JI IEEE Commun. Mag. PD OCT PY 2012 VL 50 IS 10 BP 36 EP 36 PG 1 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA 019HO UT WOS:000309729100002 ER PT J AU Tortonesi, M Stefanelli, C Benvegnu, E Ford, K Suri, N Linderman, M AF Tortonesi, Mauro Stefanelli, Cesare Benvegnu, Erika Ford, Ken Suri, Niranjan Linderman, Mark TI Multiple-UAV Coordination and Communications in Tactical Edge Networks SO IEEE COMMUNICATIONS MAGAZINE LA English DT Article ID SYSTEMS AB Unmanned aerial vehicles are becoming prevalent in tactical networks as they are proving to be an extremely flexible platform for a variety of applications. Increasingly, UAVs need to cooperate with each other in order to perform complex tasks such as target monitoring and prosecution, information gathering and processing, and delivery between disconnected portions of the network. However, UAV cooperation in tactical scenarios represents a major challenge from both the coordination and communication perspectives. In fact, cooperating UAVs must achieve a high degree of coordination in order to accomplish complex tasks in a dynamic and uncertain environment. In turn, as UAVs interact with other entities, the effective coordination of multiple-UAV operations requires specific support in terms of efficient communication protocols and mechanisms exploiting UAVs as mobile assets that facilitate and hasten critical information flows. This article presents a series of considerations and lessons learned that we have collected in our experience with multiple-UAV coordination and communications in tactical edge networks, and discusses some of the main components of a middleware we specifically designed to support multiple-UAV operations. C1 [Tortonesi, Mauro; Stefanelli, Cesare] Univ Ferrara, Dept Engn, I-44100 Ferrara, Italy. [Suri, Niranjan] USA, Res Lab, Adelphi, MD USA. [Linderman, Mark] USAF, Res Lab, Informat Directorate, Informat Management Technol Area, Washington, DC USA. RP Tortonesi, M (reprint author), Univ Ferrara, Dept Engn, I-44100 Ferrara, Italy. EM mauro.tortonesi@unife.it; cesare.stefanelli@unife.it; ebenvegnu@ihmc.us; kford@ihmc.us; nsuri@ihmc.us; Mark.Linderman@rl.af.mil OI Tortonesi, Mauro/0000-0002-7417-4455 NR 17 TC 15 Z9 15 U1 0 U2 28 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0163-6804 J9 IEEE COMMUN MAG JI IEEE Commun. Mag. PD OCT PY 2012 VL 50 IS 10 BP 48 EP 55 PG 8 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA 019HO UT WOS:000309729100004 ER PT J AU Witzel, J AF Witzel, John TI Constructing a Thermoscope SO IEEE INSTRUMENTATION & MEASUREMENT MAGAZINE LA English DT Editorial Material DE Temperature measurement; Ocean temperature; Meteorology; Thermoscopes; Thermometers C1 [Witzel, John] Paladin S, Kandahar, Afghanistan. [Witzel, John] USA, Washington, DC USA. RP Witzel, J (reprint author), Paladin S, Kandahar, Afghanistan. EM john.witzel@gmail.com NR 0 TC 0 Z9 0 U1 0 U2 0 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1094-6969 J9 IEEE INSTRU MEAS MAG JI IEEE Instrum. Meas. Mag. PD OCT PY 2012 VL 15 IS 5 BP 52 EP 53 DI 10.1109/MIM.2012.6314517 PG 2 WC Engineering, Electrical & Electronic; Instruments & Instrumentation SC Engineering; Instruments & Instrumentation GA 019HF UT WOS:000309728000011 ER PT J AU Chung, DJ Polcawich, RG Pulskamp, JS Papapolymerou, J AF Chung, David J. Polcawich, Ronald G. Pulskamp, Jeffrey S. Papapolymerou, John TI Reduced-Size Low-Voltage RF MEMS X-Band Phase Shifter Integrated on Multilayer Organic Package SO IEEE TRANSACTIONS ON COMPONENTS PACKAGING AND MANUFACTURING TECHNOLOGY LA English DT Article DE Liquid crystal polymers; microelectromechanical systems; phase shifters; piezoelectric devices; radio frequency ID LIQUID-CRYSTAL POLYMER; SYSTEM-ON-PACKAGE; MODULES AB This paper presents an X-band two-bit phase shifter that integrates single-pole four-throw (SP4T) piezoelectric micro-electromechanical switches with a compact 3-D passive design on a liquid crystal polymer (LCP) organic substrate. The multilayer LCP process allows a low-cost and lightweight circuit that can easily be integrated with other radio frequency front-end components, such as an antenna, at the packaging level. By routing lines onto embedded multilayers, a 22.5% reduction in area is achieved. In addition, low-loss piezoelectric SP4T switches with a 7 V actuation voltage are used to switch between different phase delays. The phase shifter exhibits a loss of 0.75 dB/bit with 2.25 degrees average phase error at 10 GHz. C1 [Chung, David J.; Papapolymerou, John] Georgia Inst Technol, Dept Elect & Comp Engn, Atlanta, GA 30308 USA. [Polcawich, Ronald G.; Pulskamp, Jeffrey S.] USA, Res Lab, Micro & Nano Elect Mat & Devices Branch, Adelphi, MD 20783 USA. RP Chung, DJ (reprint author), Georgia Inst Technol, Dept Elect & Comp Engn, Atlanta, GA 30308 USA. EM gth049a@mail.gatech.edu; ronald.g.polcawich.civ@mail.mil; jeffrey.pulskamp1@us.army.mil; john.papapolymerou@ece.gatech.edu NR 14 TC 3 Z9 3 U1 1 U2 16 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 2156-3950 EI 2156-3985 J9 IEEE T COMP PACK MAN JI IEEE Trans. Compon. Pack. Manuf. Technol. PD OCT PY 2012 VL 2 IS 10 BP 1617 EP 1622 DI 10.1109/TCPMT.2012.2184112 PG 6 WC Engineering, Manufacturing; Engineering, Electrical & Electronic; Materials Science, Multidisciplinary SC Engineering; Materials Science GA 019HQ UT WOS:000309729400007 ER PT J AU Hsu, AA von Elten, K Chan, D Flynn, T Walker, K Barnhill, J Naun, C Pedersen, AM Ponaman, M Fredericks, GJ Crudo, DF Pinsker, JE AF Hsu, Angela A. von Elten, Kelley Chan, Debora Flynn, Tracy Walker, Kevin Barnhill, Jason Naun, Christopher Pedersen, Anita M. Ponaman, Michael Fredericks, Gregory J. Crudo, David F. Pinsker, Jordan E. TI Characterization of the Cortisol Stress Response to Sedation and Anesthesia in Children SO JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM LA English DT Article ID SALIVARY CORTISOL; ADRENAL INSUFFICIENCY; CHILDHOOD; SURGERY AB Context: The cortisol stress response to sedation and anesthesia in children is not well characterized. It is not clear whether it is necessary to give stress doses of corticosteroids to children with adrenal insufficiency undergoing sedated procedures. Objective: Our objective was to describe the cortisol stress response to sedation and anesthesia in normal children. Design, Setting, and Patients: This was a prospective cohort study of 149 children ages 1 month to 17 yr who presented for routine sedated procedures. Salivary cortisol was measured at baseline, every 30 min during procedures, at completion, and at recovery. Main Outcome Measures: We evaluated relative change in salivary cortisol from baseline for level of sedation achieved and type of procedure performed. Results: In total, 117 patients had adequate samples collected, and 110 were included in the main analysis. Twenty-five percent of patients showed an increase in salivary cortisol greater than four times baseline, consistent with a stress response. Mean salivary cortisol increased more than 3-fold from baseline (3.7 +/- 0.4, P < 0.001) for all patients in the study. There was no difference for change in cortisol when comparing by level of sedation achieved or by type of procedure performed. The majority of patients with a stress response had their highest levels in the recovery phase, after their procedure was completed. Conclusion: Sedation and anesthesia can induce a significant rise in cortisol in children. Additional studies should be performed to validate our results and to determine whether stress dosing of corticosteroids may be needed for children with adrenal insufficiency undergoing sedated procedures. (J Clin Endocrinol Metab 97: E1830-E1835, 2012) C1 [Pinsker, Jordan E.] Tripler Army Med Ctr, Dept Pediat, Honolulu, HI 96859 USA. [Barnhill, Jason] Tripler Army Med Ctr, Dept Clin Invest, Honolulu, HI 96859 USA. [Fredericks, Gregory J.] USA, Publ Hlth Command, Aberdeen, MD 21010 USA. [Crudo, David F.] Wake Forest Univ, Bowman Gray Sch Med, Dept Pediat, Winston Salem, NC 27157 USA. RP Pinsker, JE (reprint author), Tripler Army Med Ctr, Dept Pediat, Mail Code MCHK PE,1 Jarrett White Rd, Honolulu, HI 96859 USA. EM jordan.pinsker@us.army.mil OI Pinsker, Jordan/0000-0003-4080-9034 FU Department of Clinical Investigation, Tripler Army Medical Center FX Funding for this project was provided by the Department of Clinical Investigation, Tripler Army Medical Center. NR 17 TC 7 Z9 8 U1 1 U2 5 PU ENDOCRINE SOC PI CHEVY CHASE PA 8401 CONNECTICUT AVE, SUITE 900, CHEVY CHASE, MD 20815-5817 USA SN 0021-972X J9 J CLIN ENDOCR METAB JI J. Clin. Endocrinol. Metab. PD OCT 1 PY 2012 VL 97 IS 10 BP E1830 EP E1835 DI 10.1210/jc.2012-1499 PG 6 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA 018MH UT WOS:000309664400001 PM 22855336 ER PT J AU Olderog, CK Schmitz, GR Bruner, DR Pittoti, R Williams, J Ouyang, K AF Olderog, Cameron K. Schmitz, Gillian R. Bruner, David R. Pittoti, Rebecca Williams, Justin Ouyang, Ken TI CLINICAL AND EPIDEMIOLOGIC CHARACTERISTICS AS PREDICTORS OF TREATMENT FAILURES IN UNCOMPLICATED SKIN ABSCESSES WITHIN SEVEN DAYS AFTER INCISION AND DRAINAGE SO JOURNAL OF EMERGENCY MEDICINE LA English DT Article DE MRSA; cellulitis; abscess; antibiotics ID RESISTANT STAPHYLOCOCCUS-AUREUS; SOFT-TISSUE INFECTIONS; EMERGENCY-DEPARTMENT; RISK-FACTORS; PREVALENCE AB Background: Community-acquired methicillin-resistant Staphylococcus aureus (MRSA) is now the leading cause of superficial abscesses seen in the Emergency Department. Study Objectives: Our primary aim was to determine if an association exists between three predictor variables (abscess size, cellulitis size, and MRSA culture) and treatment failure within 7 days after incision and drainage in adults. Our secondary aim was to determine if an association exists between two clinical features (abscess size and size of surrounding cellulitis) and eventual MRSA diagnosis by culture. Methods: Logistic regression models were used to examine clinical variables as predictors of treatment failure within 7 days after incision and drainage and MRSA by wound culture. Results: Of 212 study participants, 190 patients were analyzed and 22 were lost to follow-up. Patients who grew MRSA, compared to those who did not, were more likely to fail treatment (31% to 10%, respectively; 95% confidence interval [CI] 8-31%). The failure rates for abscesses >= 5 cm and < 5 cm were 26% and 22%, respectively (95% CI -11-26%). The failure rates for cellulitis >= 5 cm and < 5 cm were 27% and 16%, respectively (95% CI -2-22%). Larger abscesses were no more likely to grow MRSA than smaller abscesses (55% vs. 53%, respectively; 95% CI -22-23%). The patients with larger-diameter cellulitis demonstrated a slightly higher rate of MRSA-positive culture results compared to patients with smaller-diameter cellulitis (61% vs. 46%, respectively; 95% CI -0.3-30%), but the difference was not statistically significant. Conclusion: Cellulitis and abscess size do not predict treatment failures within 7 days, nor do they predict which patients will have MRSA. MRSA-positive patients are more likely to fail treatment within 7 days of incision and drainage. Published by Elsevier Inc. C1 [Olderog, Cameron K.] Brooke Army Med Ctr, Dept Emergency Med, Ft Sam Houston, TX 78234 USA. [Schmitz, Gillian R.] Georgetown Univ, Med Ctr, Dept Emergency Med, Washington, DC 20007 USA. [Bruner, David R.] Portsmouth Naval Med Ctr, Dept Emergency Med, Portsmouth, VA USA. [Pittoti, Rebecca] Wilford Hall USAF Med Ctr, Dept Emergency Med, San Antonio, TX USA. [Williams, Justin] Univ Texas Hlth Sci Ctr San Antonio, Dept Emergency Med, San Antonio, TX 78229 USA. [Ouyang, Ken] Univ Texas Hlth Sci Ctr San Antonio, Dept Epidemiol & Biostat, San Antonio, TX 78229 USA. RP Olderog, CK (reprint author), DeWitt Army Hosp, Dept Emergency Med, 9501 Farrel Rd, Ft Belvoir, VA 22060 USA. NR 13 TC 3 Z9 3 U1 0 U2 3 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0736-4679 J9 J EMERG MED JI J. Emerg. Med. PD OCT PY 2012 VL 43 IS 4 BP 605 EP 611 DI 10.1016/j.jemermed.2011.09.037 PG 7 WC Emergency Medicine SC Emergency Medicine GA 017FY UT WOS:000309576700024 PM 22698825 ER PT J AU Morgan, TL Tomich, EB AF Morgan, Trent L. Tomich, Eric B. TI OVERWHELMING POST-SPLENECTOMY INFECTION (OPSI): A CASE REPORT AND REVIEW OF THE LITERATURE SO JOURNAL OF EMERGENCY MEDICINE LA English DT Review DE overwhelming post-splenectomy infection (OPSI); asplenic; sepsis ID BABESIOSIS; PREVENTION; ADULTS; SEPSIS AB Background: Overwhelming postsplenectomy infection (OPSI) is a serious disease that can progress from a mild flu-like illness to fulminant sepsis in a short time period. Although relatively rare, it has a high mortality rate with delayed or inadequate treatment, and therefore, it is important for Emergency Physicians to be familiar with it. Patients who are asplenic or hyposplenic are at an increased risk for infection and death from encapsulated organisms and other dangerous pathogens. Objectives: There is an abundance of literature discussing OPSI from the perspective of hematologists and infectious disease specialists, but an Emergency Medicine perspective is necessary to truly understand the acute nature of the disease. The objective of this article is to present a careful examination of the literature with a focus on early diagnosis and management to provide Emergency Physicians with the ability to positively affect outcomes of this deadly disease. Case Report: We present the case of a well-appearing 5-month-old girl with congenital asplenia who presented to the Emergency Department with fever, and rapidly progressed to septic shock as a result of OPSI. Aggressive resuscitation was initiated, including empiric antibiotics, and after a prolonged hospital course in the pediatric intensive care unit, the child recovered. Conclusion: Rapid identification of patients at risk for OPSI, followed by administration of intravenous antibiotics, usually vancomycin and ceftriaxone, combined with early goal-directed therapy, are the keys to successful treatment. If initiated early in the patient's course, the 70% mortality rate can be reduced to the 10-40% range. Published by Elsevier Inc. C1 [Morgan, Trent L.] San Antonio Mil Med Ctr, San Antonio, TX 78240 USA. [Tomich, Eric B.] Brooke Army Med Ctr, Dept Emergency Med, San Antonio, TX USA. RP Morgan, TL (reprint author), San Antonio Mil Med Ctr, 2200 Bergquist Dr,Ste 1, San Antonio, TX 78240 USA. NR 17 TC 24 Z9 28 U1 2 U2 15 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0736-4679 J9 J EMERG MED JI J. Emerg. Med. PD OCT PY 2012 VL 43 IS 4 BP 758 EP 763 DI 10.1016/j.jemermed.2011.10.029 PG 6 WC Emergency Medicine SC Emergency Medicine GA 017FY UT WOS:000309576700064 PM 22726665 ER PT J AU Watson, S AF Watson, Samuel TI Trusting to "the Chapter of Accidents": Contingency, Necessity, and Self-Constraint in Jeffersonian National Security Policy SO JOURNAL OF MILITARY HISTORY LA English DT Article ID DEFENSE AB James Madison faced a difficult war because of Republican antipathy to taxation, debt, standing armies, federal aid to infrastructure, and a national bank. Many Republicans shared Thomas Jefferson's faith that an untrained militia could easily conquer Canada, but they did not improve militia training or administration. Indeed, Jefferson gutted the army's fledgling supply organization in 1802, an act far more significant for the War of 1812 than the creation of the Military Academy. Jefferson boxed himself and his successor into a corner by refusing to negotiate with Britain on realistic terms and by relying on commercial sanctions that damaged the economy and devastated revenues. Reactive and backward-looking, the Jeffersonian Republicans refused to match ends and means and failed to create a viable deterrent or alternative to war. C1 US Mil Acad, West Point, NY 10996 USA. RP Watson, S (reprint author), US Mil Acad, West Point, NY 10996 USA. NR 101 TC 1 Z9 1 U1 0 U2 1 PU SOC MILITARY HISTORY PI LEXINGTON PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA 24450-1600 USA SN 0899-3718 J9 J MILITARY HIST JI J. Mil. Hist. PD OCT PY 2012 VL 76 IS 4 SI SI BP 973 EP 1000 PG 28 WC History SC History GA 015YP UT WOS:000309484500003 ER PT J AU Barbuto, RV AF Barbuto, Richard V. TI First Campaign of an ADC: The War of 1812 Memoir of Lieutenant William Jenkins Worth, United States Army SO JOURNAL OF MILITARY HISTORY LA English DT Book Review C1 [Barbuto, Richard V.] USA, Command & Gen Staff Coll, Ft Leavenworth, KS USA. RP Barbuto, RV (reprint author), USA, Command & Gen Staff Coll, Ft Leavenworth, KS USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU SOC MILITARY HISTORY PI LEXINGTON PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA 24450-1600 USA SN 0899-3718 J9 J MILITARY HIST JI J. Mil. Hist. PD OCT PY 2012 VL 76 IS 4 SI SI BP 1213 EP 1214 PG 2 WC History SC History GA 015YP UT WOS:000309484500022 ER PT J AU Barbuto, RV AF Barbuto, Richard V. TI 1812: War with America SO JOURNAL OF MILITARY HISTORY LA English DT Book Review C1 [Barbuto, Richard V.] USA, Command & Gen Staff Coll, Ft Leavenworth, KS USA. RP Barbuto, RV (reprint author), USA, Command & Gen Staff Coll, Ft Leavenworth, KS USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU SOC MILITARY HISTORY PI LEXINGTON PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA 24450-1600 USA SN 0899-3718 J9 J MILITARY HIST JI J. Mil. Hist. PD OCT PY 2012 VL 76 IS 4 SI SI BP 1222 EP 1223 PG 2 WC History SC History GA 015YP UT WOS:000309484500028 ER PT J AU Bonura, MA Watson, S AF Bonura, Michael A. Watson, Samuel TI With a Sword in One Hand and Jomini in the Other: The Problem of Military Thought in the Civil War North SO JOURNAL OF MILITARY HISTORY LA English DT Book Review C1 [Watson, Samuel] US Mil Acad, West Point, NY 10996 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU SOC MILITARY HISTORY PI LEXINGTON PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA 24450-1600 USA SN 0899-3718 EI 1543-7795 J9 J MILITARY HIST JI J. Mil. Hist. PD OCT PY 2012 VL 76 IS 4 SI SI BP 1229 EP 1232 PG 4 WC History SC History GA 015YP UT WOS:000309484500033 ER PT J AU Stapleton, JM AF Stapleton, John M. TI In Search of Glory in Flanders 1707-08: The Sun King and the Spanish Succession SO JOURNAL OF MILITARY HISTORY LA English DT Book Review C1 [Stapleton, John M.] US Mil Acad, West Point, NY 10996 USA. RP Stapleton, JM (reprint author), US Mil Acad, West Point, NY 10996 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU SOC MILITARY HISTORY PI LEXINGTON PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA 24450-1600 USA SN 0899-3718 J9 J MILITARY HIST JI J. Mil. Hist. PD OCT PY 2012 VL 76 IS 4 SI SI BP 1239 EP 1241 PG 3 WC History SC History GA 015YP UT WOS:000309484500039 ER PT J AU House, JM AF House, Jonathan M. TI Stalin's General: The Life of Georgy Zhukov SO JOURNAL OF MILITARY HISTORY LA English DT Book Review C1 [House, Jonathan M.] USA, Command & Gen Staff Coll, Ft Leavenworth, KS USA. RP House, JM (reprint author), USA, Command & Gen Staff Coll, Ft Leavenworth, KS USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU SOC MILITARY HISTORY PI LEXINGTON PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA 24450-1600 USA SN 0899-3718 J9 J MILITARY HIST JI J. Mil. Hist. PD OCT PY 2012 VL 76 IS 4 SI SI BP 1275 EP 1276 PG 2 WC History SC History GA 015YP UT WOS:000309484500066 ER PT J AU Fischer, JR AF Fischer, Joseph R. TI Omar Bradley: General at War SO JOURNAL OF MILITARY HISTORY LA English DT Book Review C1 [Fischer, Joseph R.] USA, Command & Gen Staff Coll, Ft Leavenworth, KS USA. RP Fischer, JR (reprint author), USA, Command & Gen Staff Coll, Ft Leavenworth, KS USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU SOC MILITARY HISTORY PI LEXINGTON PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA 24450-1600 USA SN 0899-3718 J9 J MILITARY HIST JI J. Mil. Hist. PD OCT PY 2012 VL 76 IS 4 SI SI BP 1287 EP 1289 PG 3 WC History SC History GA 015YP UT WOS:000309484500073 ER PT J AU Stewart, RW AF Stewart, Richard W. TI Operation Anaconda: America's First Major Battle in Afghanistan SO JOURNAL OF MILITARY HISTORY LA English DT Book Review C1 [Stewart, Richard W.] USA, Ctr Mil Hist, Washington, DC USA. RP Stewart, RW (reprint author), USA, Ctr Mil Hist, Washington, DC USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU SOC MILITARY HISTORY PI LEXINGTON PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA 24450-1600 USA SN 0899-3718 J9 J MILITARY HIST JI J. Mil. Hist. PD OCT PY 2012 VL 76 IS 4 SI SI BP 1311 EP 1312 PG 2 WC History SC History GA 015YP UT WOS:000309484500087 ER PT J AU Hallengard, D Applequist, SE Nystrom, S Maltais, AK Marovich, M Moss, B Earl, P Nihlmark, K Wahren, B Brave, A AF Hallengard, David Applequist, Steven E. Nystrom, Sanna Maltais, Anna-Karin Marovich, Mary Moss, Bernard Earl, Patricia Nihlmark, Kopek Wahren, Britta Brave, Andreas TI Immunization with Multiple Vaccine Modalities Induce Strong HIV-Specific Cellular and Humoral Immune Responses SO VIRAL IMMUNOLOGY LA English DT Article ID IMMUNODEFICIENCY-VIRUS TYPE-1; CD8(+) T-CELL; GP120 PROTEIN; DOUBLE-BLIND; DNA; IMMUNOGENICITY; PRIME; ELECTROPORATION; CHALLENGE; ANTIBODY AB Heterologous priming and boosting with antigens expressed by DNA, viral vectors, or as proteins, are experimental strategies to induce strong immune responses against infectious diseases and cancer. In a preclinical study we compared the ability of recombinant modified vaccinia Ankara encoding HIV antigens (MVA-CMDR), and/or recombinant gp140C (rgp140C), to boost responses induced by a multigene/multisubtype HIV DNA vaccine delivered by electroporation (EP). Homologous DNA immunizations augmented by EP stimulated strong cellular immune responses. Still stronger cellular immune responses were observed after DNA priming and MVA-CMDR boosting, which was superior to all other immunization schedules tested in terms of antigen-specific IFN-gamma, IL-2, and bifunctional IFN-g and IL-2 responses. For HIV Env-specific antibody responses, mice receiving repeated rgp140C immunizations, and mice boosted with rgp140C, elicited the highest binding titers and the highest numbers of antibody-secreting B cells. When considering both cellular and humoral immune responses, a combination of DNA, MVA-CMDR, and rgp140C immunizations induced the overall most potent immune responses and the highest avidity of HIV Env-specific antibodies. These data emphasize the importance of including multiple vaccine modalities that can stimulate both T and B cells, and thus elicit strong and balanced immune responses. The present HIV vaccine combination holds promise for further evaluation in clinical trials. C1 [Hallengard, David; Wahren, Britta; Brave, Andreas] Karolinska Inst, Dept Microbiol Tumor & Cell Biol, S-17177 Stockholm, Sweden. [Applequist, Steven E.; Nystrom, Sanna] Karolinska Inst, Ctr Infect Med, Huddinge, Sweden. [Maltais, Anna-Karin] Cyto Pulse Sci Inc, Solna, Sweden. [Marovich, Mary] Walter Reed Army Inst Res, US Mil HIV Res Program, Rockville, MD USA. [Moss, Bernard; Earl, Patricia] NIAID, Viral Dis Lab, NIH, Bethesda, MD 20892 USA. [Nihlmark, Kopek] Mabtech AB, Nacka Strand, Sweden. RP Hallengard, D (reprint author), Karolinska Inst, Dept Microbiol Tumor & Cell Biol, Nobels Vag 16, S-17177 Stockholm, Sweden. EM david.hallengard@ki.se FU EU [LSHP-CT-2006-037611, Health-F3-2008-201433] FX We thank the EU programs EUROPRISE (LSHP-CT-2006-037611) and NGIN (Health-F3-2008-201433) for funding, and Polymun Scientific for supplying the gp140C protein vaccine candidate. NR 46 TC 4 Z9 4 U1 0 U2 4 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0882-8245 J9 VIRAL IMMUNOL JI Viral Immunol. PD OCT PY 2012 VL 25 IS 5 BP 423 EP 432 DI 10.1089/vim.2012.0046 PG 10 WC Immunology; Virology SC Immunology; Virology GA 018JX UT WOS:000309657500010 PM 23035853 ER PT J AU Spinella, PC Reddy, HL Jaffe, JS Cap, AP Goodrich, RP AF Spinella, Philip C. Reddy, Heather L. Jaffe, Jennifer S. Cap, Andrew P. Goodrich, Raymond P. TI Fresh Whole Blood Use for Hemorrhagic Shock: Preserving Benefit While Avoiding Complications SO ANESTHESIA AND ANALGESIA LA English DT Article ID RED-CELL STORAGE; IN-HOSPITAL MORTALITY; VERSUS-HOST-DISEASE; OPEN-HEART-SURGERY; PATHOGEN REDUCTION; TRAUMA PATIENTS; PHOTOCHEMICAL TREATMENT; ULTRAVIOLET-LIGHT; PLATELET TRANSFUSION; MASSIVE TRANSFUSION AB Transfusion support of patients with hemorrhagic shock has changed over time with the development of storage and processing methods. Transfusion medicine developed during World War I with the use of whole blood, and now in the developed world, component therapy predominates. In contrast, there is still clinical use of fresh whole blood (FWB) in the developing world, in a minority of children's hospitals, and in combat settings. Although there is a rationale for the use of FWB in massively bleeding patients compared with the use of individual components, it has rarely been analyzed in prospective randomized clinical trials. Recent retrospective studies in adult trauma and mixed critically ill patients have revived this decades-old controversial question of the value of FWB for patients with severe shock and coagulopathy or those at risk. The risks of FWB use have also been highlighted recently, which has caused some to focus on reducing these risks with alternative processing and storage methods. It is important to recognize that current processing and storage methods for components have also not been adequately explored to determine whether they affect clinical outcomes. In this article, we review potential benefits and risks of FWB use for patients with hemorrhagic shock from any cause, and how current and future processing and storage methods may affect efficacy and safety of FWB in this population. We intend this review to stimulate hypothesis generation and clinical investigation in determining when FWB may be indicated and how to optimally process and store FWB to maximize its risk-benefit ratio. (Anesth Analg 2012;115:751-8) C1 [Spinella, Philip C.; Jaffe, Jennifer S.] Washington Univ, Dept Pediat, St Louis, MO 63110 USA. [Reddy, Heather L.; Goodrich, Raymond P.] Terumo BCT Biotechnol LLC, Caridian BCT Biotechnol LLC, Lakewood, CO USA. [Cap, Andrew P.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Spinella, PC (reprint author), Washington Univ, St Louis Childrens Hosp, Dept Pediat, Campus Box 8116,1 Childrens Pl NWT,10th fl, St Louis, MO 63110 USA. EM spinella_p@kids.wustl.edu FU Caridian BCT Biotechnologies FX Andrew Cap received research funding from Caridian BCT Biotechnologies. NR 77 TC 15 Z9 17 U1 0 U2 5 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0003-2999 J9 ANESTH ANALG JI Anesth. Analg. PD OCT PY 2012 VL 115 IS 4 BP 751 EP 758 DI 10.1213/ANE.0b013e318261f40e PG 8 WC Anesthesiology SC Anesthesiology GA 016AU UT WOS:000309490500003 PM 22763908 ER PT J AU Carrieri, AH Buican, TN Roese, ES Sutter, J Samuels, AC AF Carrieri, Arthur H. Buican, Tudor N. Roese, Erik S. Sutter, James Samuels, Alan C. TI Thermal luminescence spectroscopy chemical imaging sensor SO APPLIED OPTICS LA English DT Article ID IRREVERSIBLE-PROCESSES; RECIPROCAL RELATIONS; MODEL AB The authors present a pseudo-active chemical imaging sensor model embodying irradiative transient heating, temperature nonequilibrium thermal luminescence spectroscopy, differential hyperspectral imaging, and artificial neural network technologies integrated together. We elaborate on various optimizations, simulations, and animations of the integrated sensor design and apply it to the terrestrial chemical contamination problem, where the interstitial contaminant compounds of detection interest (analytes) comprise liquid chemical warfare agents, their various derivative condensed phase compounds, and other material of a life-threatening nature. The sensor must measure and process a dynamic pattern of absorptive-emissive middle infrared molecular signature spectra of subject analytes to perform its chemical imaging and standoff detection functions successfully. C1 [Carrieri, Arthur H.; Roese, Erik S.; Samuels, Alan C.] USA, Res Dev & Engn Command RDECOM, Edgewood Chem Biol Ctr, Res & Technol Directorate, Aberdeen Proving Ground, MD 21010 USA. [Buican, Tudor N.] Semiot Engn Associates LLC, Albuquerque, NM 87108 USA. RP Carrieri, AH (reprint author), USA, Res Dev & Engn Command RDECOM, Edgewood Chem Biol Ctr, Res & Technol Directorate, 5183 Blackhawk Rd, Aberdeen Proving Ground, MD 21010 USA. EM arthur.h.carrieri.civ@mail.mil FU office of the Joint Project Executive Office for Chemical Biological Defense; U.S. Department of Defense; U.S. Army Research Laboratory Major Shared Resource Center; High Performance Computing Modernization Program; ECBC FX The office of the Joint Project Executive Office for Chemical Biological Defense, U.S. Department of Defense, endorsed the Small Business Innovative Research CB defense topic "Ultra High-Speed Spectroradiometry for Contamination Reconnaissance and Surveillance" against which this research was partially funded. Additional support came from a grant of computer time on the U.S. Army Research Laboratory Major Shared Resource Center, High Performance Computing Modernization Program. Senior leadership at ECBC also provided funds through a New Initiatives proposal. We thank Debra Rapp and Mary Gobbett of ECBC for administering the latter funds used to purchase and upgrade some of the software packages mentioned in Section NR 26 TC 0 Z9 0 U1 0 U2 12 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1559-128X EI 2155-3165 J9 APPL OPTICS JI Appl. Optics PD OCT 1 PY 2012 VL 51 IS 28 BP 6765 EP 6780 DI 10.1364/AO.51.006765 PG 16 WC Optics SC Optics GA 016UI UT WOS:000309544600010 PM 23033092 ER PT J AU Petrassi, FA Hodkinson, PD Walters, PL Gaydos, SJ AF Petrassi, Frank A. Hodkinson, Peter D. Walters, P. Lynne Gaydos, Steven J. TI Hypoxic Hypoxia at Moderate Altitudes: Review of the State of the Science SO AVIATION SPACE AND ENVIRONMENTAL MEDICINE LA English DT Review DE hypoxia; altitude effects; unpressurized aircraft; supplemental oxygen; performance deficit; cognitive effect; visual disturbance ID CEREBRAL-BLOOD-FLOW; MILD ACUTE-HYPOXIA; PERCEPTUAL-MOTOR PERFORMANCE; CENTRAL-NERVOUS-SYSTEM; SPATIAL DISORIENTATION; SIMULATED ALTITUDE; HUMAN ERROR; COGNITIVE PERFORMANCE; CONTRAST SENSITIVITY; NORMOBARIC HYPOXIA AB PETRASSI FA, HODKINSON PD, WALTERS PL, GAYDOS SJ. Hypoxic hypoxia at moderate altitudes: review of the state of the science. Aviat Space Environ Med 2012; 83:975-84. Unpressurized aircraft routinely operate at altitudes where hypoxia may be of concern. A systematic literature review was conducted regarding hypoxic impairment, including mental functions, sensory deficits, and other pertinent research findings that may affect aviation-related duties at moderate altitude (8000 to 15,000 ft/2438 to 4572 m). The results of this review suggest that cognitive and psychomotor deficits may include learning, reaction time, decision-making, and certain types of memory. However, results are difficult to quantify and reliably reproduce. Inconsistency of results may be related to the subtlety of deficits compared to high altitude, differences among individual compensatory mechanisms, variation in methodology or sensitivity of metrics, presence or absence of exercise, heterogeneous neuronal central nervous system (CNS) response, and interindividual variation. Literature regarding hypoxic visual decrements is more consistent. Rod photoreceptors are more susceptible to hypoxia; visual degradation has been demonstrated at 4000 to 5000 ft (1219 to 1524 m) under scotopic and 10,000 ft (3048 m) under photopic conditions. Augmented night vision goggle resolution demonstrates more resilience to mild hypoxic effects than the unaided eye under starlight conditions. Hypocapnia enhances visual sensitivity and contrast discrimination. Hyperventilation with resulting respiratory alkalosis and cerebral vasoconstriction may confound both cognitive/psychomotor and visual experimental results. Future research should include augmentation of validated neuropsychological metrics (surrogate investigational end points) with actual flight metrics, investigation of mixed gas formulations, contribution of hypocapnic vasoconstrictive effects on hypoxic performance, and further investigation into cellular- and systems-level approaches for heterogeneous CNS response. Research is also required into the contribution of mild-moderate hypoxia in human factors- and spatial disorientation-related mishaps. C1 [Petrassi, Frank A.; Hodkinson, Peter D.; Walters, P. Lynne; Gaydos, Steven J.] USA, Aeromed Res Lab, Ft Rucker, AL USA. RP Petrassi, FA (reprint author), USASAM, 301 Andrews Ave, Ft Rucker, AL 36362 USA. EM frank.petrassi@us.army.mil NR 97 TC 22 Z9 24 U1 3 U2 35 PU AEROSPACE MEDICAL ASSOC PI ALEXANDRIA PA 320 S HENRY ST, ALEXANDRIA, VA 22314-3579 USA SN 0095-6562 J9 AVIAT SPACE ENVIR MD JI Aviat. Space Environ. Med. PD OCT PY 2012 VL 83 IS 10 BP 975 EP 984 DI 10.3357/ASEM.3315.2012 PG 10 WC Public, Environmental & Occupational Health; Medicine, General & Internal; Sport Sciences SC Public, Environmental & Occupational Health; General & Internal Medicine; Sport Sciences GA 013TO UT WOS:000309329000008 PM 23066620 ER PT J AU Zheng, L Enewold, L Zahm, SH Shriver, CD Zhou, J Marrogi, A McGlynn, KA Zhu, KM AF Zheng, Li Enewold, Lindsey Zahm, Shelia H. Shriver, Craig D. Zhou, Jing Marrogi, Aizen McGlynn, Katherine A. Zhu, Kangmin TI Lung Cancer Survival among Black and White Patients in an Equal Access Health System SO CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION LA English DT Article ID AFRICAN-AMERICAN PATIENTS; LEUKEMIA GROUP-B; RACIAL DISPARITIES; BREAST-CANCER; SOCIOECONOMIC-STATUS; LARGE COHORT; STAGE; DIAGNOSIS; OUTCOMES; RACE AB Background: Racial disparities in lung cancer outcomes have been observed in the general population. However, it is unclear whether survival differences persist when patients have equal access to health care. Our objective was to determine if lung cancer survival differed among black and white patients in the U.S. Military Health System (MHS), an equal access health care system. Methods: The study subjects were 10,181 black and white patients identified through the Department of Defense's Automated Central Tumor Registry, who were 20 years old or more and diagnosed with lung cancer between 1990 and 2003. Racial differences in all-cause survival were examined using the Kaplan-Meier method and Cox proportional hazards regression models stratified by histology. For comparison, survival rates in the general population were calculated using Surveillance Epidemiology and End Results-9 data. Results: Analyses included 9,154 white and 1,027 black patients: 1,834 small cell lung cancers, 3,876 adenocarcinomas, 2,741 squamous cell carcinomas, and 1,730 large cell carcinomas. Although more favorable crude survival was observed among black patients than white patients with small cell lung cancer (P = 0.04), survival was similar between the two groups after covariate adjustment. Racial differences in survival were nonsignificant for adenocarcinomas, squamous cell carcinomas, and large cell carcinomas. Survival rates appeared to be better in the MHS than in the general population. Conclusions and Impact: All-cause survival was similar among black and white lung cancer patients in the MHS. Providing equal access to health care may eliminate racial disparities in lung cancer survival while improving the outcome of all cases. Cancer Epidemiol Biomarkers Prev; 21(10); 1841-7. (c) 2012 AACR. C1 [Zhu, Kangmin] US Mil Canc Inst, Program Epidemiol, Rockville, MD 20852 USA. [Zahm, Shelia H.; McGlynn, Katherine A.] NCI, Bethesda, MD 20892 USA. [Shriver, Craig D.] Walter Reed Natl Mil Med Ctr, Bethesda, MD USA. [Shriver, Craig D.; Zhu, Kangmin] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [Marrogi, Aizen] Walter Reed Army Inst Res, Silver Spring, MD USA. RP Zhu, KM (reprint author), US Mil Canc Inst, Program Epidemiol, 11300 Rockville Pike,Suite 1215, Rockville, MD 20852 USA. EM kzhu@usuhs.mil RI Zahm, Shelia/B-5025-2015 FU United States Military Cancer Institute via the Uniformed Services University of the Health Sciences under the Henry M. Jackson Foundation for the Advancement of Military Medicine FX This research was supported by the United States Military Cancer Institute via the Uniformed Services University of the Health Sciences under the auspices of the Henry M. Jackson Foundation for the Advancement of Military Medicine. The authors thank the Armed Forces Institute of Pathology for providing the ACTUR data; Dr. Hongyu Wu for her help in computer programming; and Dr. Sally Bushhouse of Minnesota Cancer Surveillance System for providing the useful MN-PATRL document. NR 29 TC 13 Z9 13 U1 0 U2 2 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 1055-9965 J9 CANCER EPIDEM BIOMAR JI Cancer Epidemiol. Biomarkers Prev. PD OCT PY 2012 VL 21 IS 10 BP 1841 EP 1847 DI 10.1158/1055-9965.EPI-12-0560 PG 7 WC Oncology; Public, Environmental & Occupational Health SC Oncology; Public, Environmental & Occupational Health GA 017FS UT WOS:000309576100029 PM 22899731 ER PT J AU Shurtleff, AC Nguyen, TL Kingery, DA Bavari, S AF Shurtleff, Amy C. Nguyen, Tam L. Kingery, David A. Bavari, Sina TI Therapeutics for filovirus infection: traditional approaches and progress towards in silico drug design SO EXPERT OPINION ON DRUG DISCOVERY LA English DT Review DE ebolavirus; filovirus; glycoprotein; library screening; marburgvirus; protein interactions; rational drug design; small molecule; structure; structure-based drug design; viral entry mechanism; viral hemorrhagic fever ID EBOLA-VIRUS GLYCOPROTEIN; MATRIX PROTEIN VP40; MARBURG HEMORRHAGIC-FEVER; NIEMANN-PICK C1; CHOLESTEROL ABSORPTION INHIBITORS; SMALL-MOLECULE INHIBITORS; DOUBLE-STRANDED-RNA; PRELIMINARY-X-RAY; CYNOMOLGUS MACAQUES; NUCLEOCAPSID PROTEINS AB Introduction: Ebolaviruses and marburgviruses cause severe and often lethal human hemorrhagic fevers. As no FDA-approved therapeutics are available for these infections, efforts to discover new therapeutics are important, especially because these pathogens are considered biothreats and emerging infectious diseases. All methods for discovering new therapeutics should be considered, including compound library screening in vitro against virus and in silico structure-based drug design, where possible, if sufficient biochemical and structural information is available. Areas covered: This review covers the structure and function of filovirus proteins, as they have been reported to date, as well as some of the current antiviral screening approaches. The authors discuss key studies mapping small-molecule modulators that were found through library and in silico screens to potential sites on viral proteins or host proteins involved in virus trafficking and pathogenesis. A description of ebolavirus and marburgvirus diseases and available animal models is also presented. Expert opinion: To discover novel therapeutics with potent efficacy using sophisticated computational methods, more high-resolution crystal structures of filovirus proteins and more details about the protein functions and host interaction will be required. Current compound screening efforts are finding active antiviral compounds, but an emphasis on discovery research to investigate protein structures and functions enabling in silico drug design would provide another avenue for finding antiviral molecules. Additionally, targeting of protein-protein interactions may be a future avenue for drug discovery since disrupting catalytic sites may not be possible for all proteins. C1 [Shurtleff, Amy C.; Kingery, David A.; Bavari, Sina] USA, Med Res Inst Infect Dis, Integrated Toxicol Div, Frederick, MD 21702 USA. [Nguyen, Tam L.] NCI, Target Struct Based Drug Discovery Grp, SAIC Frederick, Frederick, MD 21702 USA. RP Shurtleff, AC (reprint author), USA, Med Res Inst Infect Dis, Integrated Toxicol Div, 1425 Porter St, Frederick, MD 21702 USA. EM amy.c.shurtleff.ctr@us.army.mil FU Defense Threat Reduction Agency; Transformational Medical Technologies FX This paper was sponsored by the Defense Threat Reduction Agency and Transformational Medical Technologies. The authors declare no other conflicts of interest. NR 196 TC 5 Z9 5 U1 0 U2 21 PU INFORMA HEALTHCARE PI LONDON PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND SN 1746-0441 EI 1746-045X J9 EXPERT OPIN DRUG DIS JI Expert. Opin. Drug Discov. PD OCT PY 2012 VL 7 IS 10 BP 935 EP 954 DI 10.1517/17460441.2012.714364 PG 20 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA 015QK UT WOS:000309460800005 PM 22873527 ER PT J AU Stokes, TA Holston, A Olsen, C Choi, Y Curtis, J Higginson, J Enright, L Adimora, C Hunt, CE AF Stokes, Theophil A. Holston, Alexander Olsen, Cara Choi, Young Curtis, Jerri Higginson, Jason Enright, Leah Adimora, Chinenye Hunt, Carl E. TI Preterm Infants of Lower Gestational Age at Birth Have Greater Waist Circumference-Length Ratio and Ponderal Index at Term Age than Preterm Infants of Higher Gestational Ages SO JOURNAL OF PEDIATRICS LA English DT Article ID BODY-MASS INDEX; TO-HEIGHT RATIO; CARDIOMETABOLIC RISK-FACTORS; INSULIN-RESISTANCE; METABOLIC SYNDROME; YOUNG-ADULTS; CARDIOVASCULAR-DISEASE; NUTRITIONAL-STATUS; ABDOMINAL OBESITY; BLOOD-PRESSURE AB Objective To assess anthropometric changes from birth to hospital discharge in infants born preterm and compare with a reference birth cohort of infants born full-term. Study design Retrospective chart review was conducted of 501 preterm and 1423 full-term infants. We evaluated birth and hospital discharge weight, length, and waist circumference (WC). WC/length ratio (WLR), ponderal index, and body mass index (BMI) were calculated. Preterm infants were categorized into quartiles (Q1-4) based on birth weight (BW). Results At birth mean length, WC, WLR, BMI, and ponderal index were all significantly less for preterm infants in the lowest BW quartile (Q1) than preterm infants in higher BW quartiles or full-term infants. Although their weight, length, and BMI remained significantly less at discharge, preterm infants in Q1 had a disproportionate increase in WLR and ponderal index such that at discharge their WLR and ponderal index were greater than infants in Q2-3 and comparable with infants in Q4 and full-term infants. Discharge WLR and ponderal index in Q1 were significantly higher with decreasing postmenstrual age at birth. Conclusions Preterm infants of a lower birth postmenstrual age have disproportionate increases in WLR and ponderal index that are suggestive of increased visceral and total adiposity. (J Pediatr 2012;161:735-41). C1 [Stokes, Theophil A.; Holston, Alexander; Choi, Young; Curtis, Jerri; Higginson, Jason; Hunt, Carl E.] Uniformed Serv Univ Hlth Sci, Dept Pediat, Bethesda, MD 20814 USA. [Stokes, Theophil A.; Higginson, Jason; Enright, Leah] Walter Reed Natl Mil Med Ctr, Dept Pediat, Bethesda, MD USA. [Olsen, Cara] Uniformed Serv Univ Hlth Sci, Dept Biostat, Bethesda, MD 20814 USA. USN, Med Ctr, Dept Pediat, Portsmouth, VA USA. [Choi, Young] Womack Army Med Ctr, Dept Med, Ft Bragg, NC USA. [Choi, Young] Womack Army Med Ctr, Dept Pediat, Ft Bragg, NC USA. [Adimora, Chinenye] Walter Reed Natl Mil Med Ctr, Dept Obstet & Gynecol, Bethesda, MD USA. RP Stokes, TA (reprint author), Uniformed Serv Univ Hlth Sci, Dept Pediat, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA. EM Theophil.Stokes@usuhs.edu NR 44 TC 10 Z9 10 U1 0 U2 2 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0022-3476 J9 J PEDIATR-US JI J. Pediatr. PD OCT PY 2012 VL 161 IS 4 BP 735 EP + DI 10.1016/j.jpeds.2012.03.023 PG 8 WC Pediatrics SC Pediatrics GA 016KH UT WOS:000309516400035 PM 22534153 ER PT J AU Panchal, RG Geller, BL Mellbye, B Lane, D Iversen, PL Bavari, S AF Panchal, Rekha G. Geller, Bruce L. Mellbye, Brett Lane, Douglas Iversen, Patrick L. Bavari, Sina TI Peptide Conjugated Phosphorodiamidate Morpholino Oligomers Increase Survival of Mice Challenged with Ames Bacillus anthracis SO NUCLEIC ACID THERAPEUTICS LA English DT Article ID COLI-IN-VITRO; ESCHERICHIA-COLI; PURE CULTURE; RESISTANCE; ANTIBIOTICS; DOXYCYCLINE; INHIBITION; BACTERIA; STERNE; GROWTH AB Targeting bacterial essential genes using antisense phosphorodiamidate morpholino oligomers (PMOs) represents an important strategy in the development of novel antibacterial therapeutics. PMOs are neutral DNA analogues that inhibit gene expression in a sequence-specific manner. In this study, several cationic, membrane-penetrating peptides were conjugated to PMOs (PPMOs) that target 2 bacterial essential genes: acyl carrier protein (acpP) and gyrase A (gyrA). These were tested for their ability to inhibit growth of Bacillus anthracis, a gram-positive spore-forming bacterium and causative agent of anthrax. PPMOs targeted upstream of both target gene start codons and conjugated with the bacterium-permeating peptide (RFF)(3)R were found to be most effective in inhibiting bacterial growth in vitro. Both of the gene-targeted PPMOs protected macrophages from B. anthracis induced cell death. Subsequent, in vivo testing of the PPMOs resulted in increased survival of mice challenged with the virulent Ames strain of B. anthracis. Together, these studies suggest that PPMOs targeting essential genes have the potential of being used as antisense antibiotics to treat B. anthracis infections. C1 [Panchal, Rekha G.; Bavari, Sina] USA, Med Res Inst Infect Dis, Frederick, MD USA. [Geller, Bruce L.; Mellbye, Brett; Iversen, Patrick L.] AVI BioPharma Inc, Corvallis, OR USA. [Geller, Bruce L.; Mellbye, Brett; Iversen, Patrick L.] Oregon State Univ, Corvallis, OR 97331 USA. [Lane, Douglas] NCI, Target Struct Based Drug Discovery Grp, SAIC Frederick, Frederick, MD 21701 USA. RP Panchal, RG (reprint author), Dept Target Discovery & Expt Microbiol, 1425 Porter St, Ft Detrick, MD 21702 USA. EM rekha.panchal@amedd.army.mil OI Mellbye, Brett/0000-0002-3586-1885 FU Department of Defense Chemical Biological Defense Program through the Defense Threat Reduction Agency; National Cancer Institute, National Institutes of Health [HHSN261200800001E]; Developmental Therapeutics Program in the Division of Cancer Treatment and Diagnosis of the National Cancer Institute FX We thank Brett Eaton for technical support. This project was partially funded by the Department of Defense Chemical Biological Defense Program through the Defense Threat Reduction Agency. This project has been funded in whole or in part with federal funds from the National Cancer Institute, National Institutes of Health, under contract HHSN261200800001E. The content of this publication does not necessarily reflect the views or policies of the Department of Health and Human Services, nor does mention of trade names, commercial products, or organizations imply endorsement by the U.S. Government. This research was supported, in part, by the Developmental Therapeutics Program in the Division of Cancer Treatment and Diagnosis of the National Cancer Institute. Opinions, interpretations, conclusions, and recommendations are those of the authors and are not necessarily endorsed by the U.S. Army. NR 29 TC 6 Z9 6 U1 0 U2 3 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 2159-3337 EI 2159-3345 J9 NUCLEIC ACID THER JI Nucl. Acid Ther. PD OCT PY 2012 VL 22 IS 5 BP 316 EP 322 DI 10.1089/nat.2012.0362 PG 7 WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Medicine, Research & Experimental SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Research & Experimental Medicine GA 017MJ UT WOS:000309593700004 PM 22978365 ER PT J AU Sabatini, JJ Raab, JM Hann, RK AF Sabatini, Jesse J. Raab, James M. Hann, Ronald K. TI Mitigation of Single-Point-of-Failure: Development of M127A1 White Star Illuminant Compositions Containing an Epoxy Binder System SO PROPELLANTS EXPLOSIVES PYROTECHNICS LA English DT Article DE Pyrotechnics; Energetic materials; Illuminants; Binders; Sodium nitrate ID PERCHLORATE-FREE; PYROTECHNICS DEVELOPMENT; CIVILIAN APPLICATIONS; LIGHT ILLUMINANTS; MILITARY AB A replacement for the M127A1 hand-held signal illuminant was developed to alleviate concerns associated with single-point-of-failure. In addressing single-point-of-failure, Laminac 4116/Lupersol binder system were replaced with Epon 813/Versamid 140 binder system. Powdered sodium nitrate was replaced with prilled sodium nitrate in the disclosed formulations to minimize hygroscopicity concerns associated with this oxidizer. The performance of the prilled sodium nitrate-based formulations, their burning behaviors, and the sensitivities of the best performing illuminant toward various ignition stimuli are also described in detail. C1 [Sabatini, Jesse J.] USA, RDECOM ARDEC, Pyrotech Technol & Prototyping Div, Picatinny Arsenal, NJ 07806 USA. [Raab, James M.; Hann, Ronald K.] US Mil Acad, Dept Chem & Life Sci, West Point, NY 10996 USA. RP Sabatini, JJ (reprint author), USA, RDECOM ARDEC, Pyrotech Technol & Prototyping Div, Bldg 3124, Picatinny Arsenal, NJ 07806 USA. EM jesse.sabatini@us.army.mil FU US Army (Picatinny Arsenal, NJ) FX The authors thank the US Army (Picatinny Arsenal, NJ) for funding of this work. The authors are indebted to the United States Military Academy Department of Chemistry and Life Sciences (West Point, NY) for their coordination during the Academic Individual Advanced Development (AIAD) program. Mr. Henry Grau is gratefully acknowledged for providing thermal onset values. NR 11 TC 3 Z9 3 U1 0 U2 4 PU WILEY-V C H VERLAG GMBH PI WEINHEIM PA BOSCHSTRASSE 12, D-69469 WEINHEIM, GERMANY SN 0721-3115 J9 PROPELL EXPLOS PYROT JI Propellants Explos. Pyrotech. PD OCT PY 2012 VL 37 IS 5 BP 592 EP 596 DI 10.1002/prep.201200068 PG 5 WC Chemistry, Applied; Engineering, Chemical SC Chemistry; Engineering GA 017NU UT WOS:000309597700011 ER PT J AU Martini, WZ AF Martini, W. Z. TI IMPACT OF ACIDOSIS AND HYPOTHERMIA SO SHOCK LA English DT Meeting Abstract CT 8th Wiggers-Bernard Conference CY FEB 17-18, 2011 CL Salzburg, AUSTRIA SP CSL Behring GmbH, AUVA, Tem Int GmbH, Haemonet Handels GmbH Austria, Fresenius Kabi Austria GmbH, Pfizer Corp Austria GmbH, Novo Nordisk Pharma GmbH, LFB Biotechnol C1 [Martini, W. Z.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1073-2322 J9 SHOCK JI Shock PD OCT PY 2012 VL 38 IS 4 SU 1 MA 3 BP 4 EP 4 PG 1 WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System & Cardiology GA 017VG UT WOS:000309618600004 ER PT J AU Spinella, PC Blackbourne, LH Holcomb, JB AF Spinella, P. C. Blackbourne, L. H. Holcomb, J. B. TI SHOULD COMBAT CASUALTIES WITH MASSIVE BLEEDING BE RESUSCITATED WITH A HIGH RATIO OF PLASMA AND PLATELETS TO RBCS? SO SHOCK LA English DT Meeting Abstract CT 8th Wiggers-Bernard Conference CY FEB 17-18, 2011 CL Salzburg, AUSTRIA SP CSL Behring GmbH, AUVA, Tem Int GmbH, Haemonet Handels GmbH Austria, Fresenius Kabi Austria GmbH, Pfizer Corp Austria GmbH, Novo Nordisk Pharma GmbH, LFB Biotechnol C1 [Spinella, P. C.] Blood Syst Res Inst, San Francisco, CA USA. [Spinella, P. C.; Blackbourne, L. H.] USA, Inst Surg Res, San Antonio, TX USA. [Holcomb, J. B.] Univ Texas Hlth Sci Ctr Houston, Houston, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1073-2322 J9 SHOCK JI Shock PD OCT PY 2012 VL 38 IS 4 SU 1 MA 17 BP 27 EP 28 PG 2 WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System & Cardiology GA 017VG UT WOS:000309618600018 ER PT J AU Halpern, BH Snider, KF AF Halpern, Barton H. Snider, Keith F. TI Products That Kill and Corporate Social Responsibility: The Case of U.S. Defense Firms SO ARMED FORCES & SOCIETY LA English DT Article DE corporate social responsibility; defense firms; defense industry; defense managers; military-industrial complex ID PERFORMANCE; INDUSTRY; ETHICS; ORIENTATIONS; PERCEPTIONS; MANAGEMENT; STUDENTS AB Scholars of corporate social responsibility (CSR), which refers to the responsibilities of a firm to society in four domains: economic, legal, ethical, and discretionary, have typically excluded defense firms from their research, mainly on ideological grounds. This study challenges these assumptions and measures the CSR orientations of managers of defense firms. The findings reveal the orientations of defense firm managers to be consistent with those of other corporate populations, though the highly regulated environment of defense contracting causes some differences. The findings help to redeem the social standing of defense firms, and by implication, their employees and the military members who use their products, from unwarranted antimilitary biases. C1 [Snider, Keith F.] USN, Grad Sch Business & Publ Policy, Postgrad Sch, Monterey, CA 93943 USA. [Halpern, Barton H.] USA, ARDEC, Picatinny Arsenal, NJ USA. RP Snider, KF (reprint author), USN, Grad Sch Business & Publ Policy, Postgrad Sch, Monterey, CA 93943 USA. EM ksnider@nps.edu NR 66 TC 0 Z9 0 U1 2 U2 11 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0095-327X J9 ARMED FORCES SOC JI Armed Forces Soc. PD OCT PY 2012 VL 38 IS 4 BP 604 EP 624 DI 10.1177/0095327X11415490 PG 21 WC Political Science; Sociology SC Government & Law; Sociology GA 013CU UT WOS:000309284100004 ER PT J AU Patzkowski, JC Kirk, KL Orr, JD Waterman, BR Kirby, JM Hsu, JR AF Patzkowski, Jeanne C. Kirk, Kevin L. Orr, Justin D. Waterman, Brian R. Kirby, Jess M. Hsu, Joseph R. TI Quantification of Posterior Ankle Exposure Through an Achilles Tendon-Splitting Versus Posterolateral Approach SO FOOT & ANKLE INTERNATIONAL LA English DT Article DE Posterolateral Ankle Approach; Achilles Tendon-Splitting Approach; Tibia Nonunion; Tibia Malunion; Posterior Tibia; Posterior Malleolus; Posterior Talus ID SURGICAL APPROACH; PILON FRACTURES; ARTHRODESIS; MALLEOLUS AB Background: The optimal surgical exposure to the posterior ankle for trauma and reconstruction is a source of debate. We hypothesized that the Achilles tendon-splitting approach would provide greater exposure to the posterior ankle than the posterolateral approach. Methods: Forty surgical approaches were performed from twenty fresh-frozen cadavers. Achilles tendon-splitting and posterolateral approaches were performed using a randomized crossover design for surgical sequence. Six landmarks (medial malleolus, ankle joint, subtalar joint, incisura fibularis, lateral malleolus and medial gutter) were identified by direct visualization or palpation. A calibrated digital photograph was taken and Image J (http://rsb.info.nih.gov/ij/) was used to calculate the surface area of the distal tibia and talus exposed in neutral and dorsiflexion. Results: Using a posterolateral approach, the average distal tibia exposed was 11.3cm(2) in neutral and 10.2 cm(2) in dorsiflexion. The average talus exposed was 2.0 cm(2) in neutral and 2.4 cm(2) in dorsiflexion. Using an Achilles tendon-splitting approach, the average exposed distal tibia was 33% more (15.0 cm(2)) in neutral and 43% more (14.6 cm(2)) in dorsiflexion. The average talus exposed was 47% more (3.0 cm(2)) in neutral and 76% more (4.2 cm(2)) in dorsiflexion. All increases in exposure were statistically significant. The medial malleolus was visualized in 19 tendon-splitting and six posterolateral approaches. The medial gutter was visualized in 20 tendon-splitting and 13 posterolateral approaches. These differences were statistically significant. All other landmarks could be visualized through both approaches. Conclusion: The Achilles tendon-splitting approach provided significantly greater exposure of the posterior distal tibia and talus compared to the posterolateral approach. Clinical relevance: Prospective studies will help determine if the tendon-splitting approach is a safe and clinically useful approach for surgeries in which direct access to the entire posterior ankle and subtalar joint are required. C1 [Patzkowski, Jeanne C.; Kirk, Kevin L.; Hsu, Joseph R.] San Antonio Mil Med Ctr, Ft Sam Houston, TX 78234 USA. [Orr, Justin D.; Waterman, Brian R.] William Beaumont Army Med Ctr, El Paso, TX 79920 USA. [Kirby, Jess M.] USA, Trauma Training Ctr, Cornelius, NC USA. RP Patzkowski, JC (reprint author), San Antonio Mil Med Ctr, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM Jeanne.patzkowski@us.army.mil FU United States Army Institute of Surgical Research FX Research funded by the United States Army Institute of Surgical Research; cadavers provided by the Combat Extremity Surgery Course. NR 23 TC 5 Z9 5 U1 0 U2 3 PU AMER ORTHOPAEDIC FOOT & ANKLE SOC, INC PI SEATTLE PA 2517 EASTLAKE AVE EAST, STE 200, SEATTLE, WA 98102 USA SN 1071-1007 J9 FOOT ANKLE INT JI Foot Ankle Int. PD OCT PY 2012 VL 33 IS 10 BP 900 EP 904 DI 10.3113/FAI.2012.0900 PG 5 WC Orthopedics SC Orthopedics GA 015ZL UT WOS:000309486800015 PM 23050716 ER PT J AU Bedair, SS Pulskamp, JS Meyer, CD Mirabelli, M Polcawich, RG Morgan, B AF Bedair, Sarah S. Pulskamp, Jeffrey S. Meyer, Christopher D. Mirabelli, Manrico Polcawich, Ronald G. Morgan, Brian TI High-Performance Micromachined Inductors Tunable by Lead Zirconate Titanate Actuators SO IEEE ELECTRON DEVICE LETTERS LA English DT Article DE Microwave devices; piezoelectric microelectromechanical system (MEMS); radio-frequency (RF) MEMS; tunable inductors ID MEMS INDUCTOR AB This letter documents the design, microfabrication, and testing of integrated and continuously tuned radio-frequency copper (Cu) inductors with low-power large-throw lead-zirconate-titanate (PZT) actuators. The devices, with inductances in the 3-10-nH range, achieved high-quality factors, Q > 10 (1-6 GHz range), and tuning ratios as high as 2.6 : 1 at 20-V actuation with nanowatt-power consumption. This was enabled by the monolithic integration of three electroplated Cu layers (similar to 10 mu m per layer) and PZT microelectromechanical system actuators. Two tunable inductor design types, positively and negatively coupled designs, and the tradeoff between tuning ratio and inductor Q are considered. C1 [Bedair, Sarah S.; Pulskamp, Jeffrey S.; Meyer, Christopher D.; Mirabelli, Manrico; Polcawich, Ronald G.; Morgan, Brian] USA, Res Lab, Adelphi, MD 20783 USA. RP Bedair, SS (reprint author), USA, Res Lab, Adelphi, MD 20783 USA. EM sarah.s.bedair.civ@mail.mil RI Bedair, Sarah/D-9130-2013 NR 11 TC 10 Z9 10 U1 1 U2 14 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0741-3106 J9 IEEE ELECTR DEVICE L JI IEEE Electron Device Lett. PD OCT PY 2012 VL 33 IS 10 BP 1483 EP 1485 DI 10.1109/LED.2012.2207700 PG 3 WC Engineering, Electrical & Electronic SC Engineering GA 014HA UT WOS:000309364600050 ER PT J AU Hakre, S Armstrong, AW O'Connell, RJ Michael, NL Scott, PT Brett-Major, DM AF Hakre, Shilpa Armstrong, Adam W. O'Connell, Robert J. Michael, Nelson L. Scott, Paul T. Brett-Major, David M. TI A Pilot Online Survey Assessing Risk Factors for HIV Acquisition in the Navy and Marine Corps, 2005-2010 SO JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES LA English DT Article DE HIV military personnel survey ID MILITARY PERSONNEL; BEHAVIOR; SEX; SUBTYPES; CARE; MEN AB The Department of Defense policy Don't Ask, Don't Tell (DADT) ended in September, 2011. The Navy Bloodborne Infection Management Center conducted a post-DADT pilot survey of HIV seroconverters identified when the DADT policy was in effect. Sailors and Marines newly diagnosed as HIV positive from 2005 to 2010 were invited to participate in an online survey. A structured questionnaire elicited risk information about the 3-year period before HIV diagnosis. Respondents reported engaging commonly in same sex sexual activity, having concurrent partners, and poor condom use for anal sex. In this first post-DADT repeal report of self-reported behaviors, male-to-male sexual contact was a much more common mode of infection than previously reported. Several opportunities for primary prevention messaging now possible after DADT repeal are evident. C1 [Hakre, Shilpa] Henry M Jackson Fdn Adv Mil Med, US Mil HIV Res Program, Bethesda, MD 20817 USA. [Armstrong, Adam W.] USN, Navy Blood borne Infect Management Ctr, Marine Corps Publ Hlth Ctr, Portsmouth, VA USA. [O'Connell, Robert J.; Michael, Nelson L.; Scott, Paul T.] Walter Reed Army Inst Res, US Mil HIV Res Program, Bethesda, MD USA. [Brett-Major, David M.] USN, Med Profess Dev Ctr, US Mil Trop Med Program, Bethesda, MD 20084 USA. [Brett-Major, David M.] Uniformed Serv Univ Hlth Sci, Dept Prevent Med & Biometr, Bethesda, MD 20814 USA. RP Hakre, S (reprint author), Henry M Jackson Fdn Adv Mil Med, US Mil HIV Res Program, 6720-A Rockledge Dr,Suite 400, Bethesda, MD 20817 USA. EM shakre@hivresearch.org FU US Navy Bureau of Medicine and Surgery; Military Infectious Diseases Research Program [MIDRP-H014010OTPPOC] FX Supported by US Navy Bureau of Medicine and Surgery and the Military Infectious Diseases Research Program, project MIDRP-H014010OTPPOC. NR 17 TC 3 Z9 3 U1 1 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1525-4135 J9 JAIDS-J ACQ IMM DEF JI JAIDS PD OCT 1 PY 2012 VL 61 IS 2 BP 125 EP 130 DI 10.1097/QAI.0b013e31826a15db PG 6 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 012EQ UT WOS:000309218700007 PM 23007117 ER PT J AU Havrylkoff, JM Peterson, MS Slack, WT AF Havrylkoff, J. -M. Peterson, M. S. Slack, W. T. TI Assessment of the seasonal usage of the lower Pascagoula River estuary by Gulf sturgeon (Acipenser oxyrinchus desotoi) SO JOURNAL OF APPLIED ICHTHYOLOGY LA English DT Article ID OF-MEXICO STURGEON; SUWANNEE RIVER; LIFE-HISTORY; SPAWNING SITE; HABITAT USE; FLORIDA; MISSISSIPPI; MIGRATION; ALABAMA; FLOW AB The Pascagoula watershed likely offers the greatest possibility for the survival of the Gulf sturgeon, Acipenser oxyrinchus desotoi, within Mississippi. Thus, understanding and preserving the connectivity between distant habitats in this region plays a major role in protecting and managing such anadromous fish populations. The focus of this project was to determine the within-river routes Gulf sturgeon take through the lower Pascagoula River downstream of the point where it splits (river kilometer 23) into two distinct distributaries. Sixty days were sampled throughout a two-year period with a total effort of 81 947 net-meter-hours and eight Gulf sturgeon were captured, ranging from 74 to 189 cm FL and weighing from 3.6 to 52.6 kg. Using an array of automated telemetry receivers, acoustically tagged Gulf sturgeon movements were monitored within the lower river and associated estuary. Estimated residence times (days) suggest Gulf sturgeon appear to prefer the eastern distributary upriver from Bayou Chemise as the primary travel corridor between freshwater habitats and marine feeding grounds. The western distributary mouth was more highly used by Gulf sturgeon during both seasonal migrations between upriver and offshore habitats. Thus, the western distributary appears to represent the main entrance point utilized by Gulf sturgeon to the Pascagoula River watershed and should be protected as the eastern distributary mouth has been altered from a natural marsh edge to one of hardened surfaces. C1 [Havrylkoff, J. -M.; Peterson, M. S.] Univ So Mississippi, Dept Coastal Sci, Ocean Springs, MS 39564 USA. [Slack, W. T.] USA, Engn Res & Dev Ctr, Waterways Expt Stn, Vicksburg, MS USA. RP Havrylkoff, JM (reprint author), Univ So Mississippi, Dept Coastal Sci, 703 E Beach Dr, Ocean Springs, MS 39564 USA. EM Jeannemarie.havrylkoff@eagles.usm.edu FU Mississippi Museum of Natural Science; USM IACUC [07081501]; USFWS Section 6 program [E-1]; USFWS [1448-40181-07-G029] FX We would like to thank R. Heard who provided guidance and support as a thesis committee member and A. Stricklin, J. Lopez, P. Grammer, M. Lowe, E. Lang, A. Charbonnet, R. Haehn, J. Wagner, M. Andreas, P. Mickle, and B. Barnes for their help in the field and laboratory. The Mississippi Museum of Natural Science provided equipment and support necessary for the completion of this project, and A. Francois and J. Copley of the agency provided assistance in the field. Phil Kirk, S. George and B. Lewis from the U.S. Army ERDC assisted with field work. Finally, we thank T. Ruth, B. J. Johnson, L. McCoy, and B. Lynd for their assistance with various aspects of this project. This work was conducted under the USM IACUC # 07081501 and funded by USFWS Section 6 program under Project No. E-1, Segment 23 and USFWS Grant # 1448-40181-07-G029. NR 28 TC 4 Z9 4 U1 2 U2 17 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0175-8659 J9 J APPL ICHTHYOL JI J. Appl. Ichthyol. PD OCT PY 2012 VL 28 IS 5 BP 681 EP 686 DI 10.1111/j.1439-0426.2012.02056.x PG 6 WC Fisheries; Marine & Freshwater Biology SC Fisheries; Marine & Freshwater Biology GA 007GY UT WOS:000308878000001 ER PT J AU Koppenhaver, SL Fritz, JM Hebert, JJ Kawchuk, GN Parent, EC Gill, NW Childs, JD Teyhen, DS AF Koppenhaver, Shane L. Fritz, Julie M. Hebert, Jeffrey J. Kawchuk, Greg N. Parent, Eric C. Gill, Norman W. Childs, John D. Teyhen, Deydre S. TI Association between history and physical examination factors and change in lumbar multifidus muscle thickness after spinal manipulation in patients with low back pain SO JOURNAL OF ELECTROMYOGRAPHY AND KINESIOLOGY LA English DT Article DE Musculoskeletal manipulations; Low back pain; Muscle contraction; Ultrasound; Lumbar multifidus ID CLINICAL-PREDICTION RULE; LEG RAISE TEST; STABILIZATION EXERCISE PROGRAM; FEAR-AVOIDANCE BELIEFS; TRANSVERSUS ABDOMINIS; PRIMARY-CARE; CENTRALIZATION PHENOMENON; DISC HERNIATION; MANUAL THERAPY; TRIAL AB Understanding the clinical characteristics of patients with low back pain (LBP) who display improved lumbar multifidus (LM) muscle function after spinal manipulative therapy (SMT) may provide insight into a potentially synergistic interaction between SMT and exercise. Therefore, the purpose of this study was to identify the baseline historical and physical examination factors associated with increased contracted LM muscle thickness one week after SMT. Eighty-one participants with LBP underwent a baseline physical examination and ultrasound imaging assessment of the LM muscle during submaximal contraction before and one week after SMT. The relationship between baseline examination variables and 1-week change in contracted LM thickness was assessed using correlation analysis and hierarchical multiple linear regression. Four variables best predicted the magnitude of increases in contracted LM muscle thickness after SMT. When combined, these variables suggest that patients with LBP, (1) that are fairly acute, (2) have at least a moderately good prognosis without focal and irritable symptoms, and (3) exhibit signs of spinal instability, may be the best candidates for a combined SMT and lumbar stabilization exercise (LSE) treatment approach. Published by Elsevier Ltd. C1 [Koppenhaver, Shane L.; Gill, Norman W.; Teyhen, Deydre S.] Baylor Univ, USA, Doctoral Program Phys Therapy, San Antonio, TX USA. [Koppenhaver, Shane L.; Hebert, Jeffrey J.] Murdoch Univ, Sch Chiropract & Sports Sci, Perth, WA, Australia. [Fritz, Julie M.] Univ Utah, Coll Hlth, Intermt Hlth Care, Salt Lake City, UT USA. [Kawchuk, Greg N.; Parent, Eric C.] Univ Alberta, Dept Phys Therapy, Edmonton, AB T6G 2M7, Canada. [Parent, Eric C.] Glenrose Rehabil Hosp, Edmonton, AB, Canada. [Childs, John D.] MSGS SGCUY, Dept Phys Therapy, Biloxi, MS USA. RP Koppenhaver, SL (reprint author), Baylor Univ, USA, Doctoral Program Phys Therapy, San Antonio, TX USA. EM shanekoppenhaver@mac.com RI Hebert, Jeffrey/C-4614-2008 OI Hebert, Jeffrey/0000-0002-6959-325X FU National Institutes of Health, National Center for Complementary and Alternative Medicine [R21 AT004221] FX The data for this study was collected using funding from the National Institutes of Health, National Center for Complementary and Alternative Medicine (R21 AT004221). The authors would like to thank Dr. Leslie Hair and Mr. Faris Al-Odaibi for their assistance with data collection. This study was approved by the Institutional Review Boards of the University of Utah and Brooke Army Medical Center. The view(s) expressed herein are those of the author(s) and do not reflect the official policy or position of Brooke Army Medical Center, the U. S. Army Medical Department, the U. S. Army Office of the Surgeon General, the Department of the Army, Department of the Air Force, Department of Defense, or the U.S. Government. NR 54 TC 8 Z9 10 U1 2 U2 22 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1050-6411 J9 J ELECTROMYOGR KINES JI J. Electromyogr. Kinesiol. PD OCT PY 2012 VL 22 IS 5 BP 724 EP 731 DI 10.1016/j.jelekin.2012.03.004 PG 8 WC Neurosciences; Physiology; Rehabilitation; Sport Sciences SC Neurosciences & Neurology; Physiology; Rehabilitation; Sport Sciences GA 013FJ UT WOS:000309291000011 PM 22516351 ER PT J AU Nguyen, PT Asarias, JR Pierce, LM AF Nguyen, Phuoc T. Asarias, Jennifer R. Pierce, Lisa M. TI Influence of a New Monofilament Polyester Mesh on Inflammation and Matrix Remodeling SO JOURNAL OF INVESTIGATIVE SURGERY LA English DT Article DE synthetic mesh; hernia repair; inflammatory cytokines; matrix metalloproteinase; chronic inflammation; monofilament; multifilament; polyester; polypropylene; polytetrafluoroethylene ID RANDOMIZED CONTROLLED-TRIALS; INGUINAL-HERNIA REPAIR; FOREIGN-BODY REACTION; POLYPROPYLENE MESH; INCISIONAL HERNIA; ABDOMINAL-WALL; GROIN HERNIA; RAT MODEL; EXPRESSION; CYTOKINES AB Synthetic mesh is widely used for hernia repairs, but mesh-induced chronic inflammatory responses may lead to postoperative complications. We previously showed an elevated response to multifilament polyester (PE) versus monofilament polypropylene (PP) and polytetrafluoroethylene (PTFE) meshes, but it is unclear whether this discrepancy is due to the differences in chemical composition or filament structure. This study compares the influence of a newly available monofilament PEmesh to that of multifilament PE, monofilament PP, and monofilament PTFE on the expression of genes important in inflammation and extracellular matrix remodeling in a rat model. Full thickness abdominal wall defects were corrected with onlay repair or suture repair with no mesh. Explants were harvested 7 or 90 days after repair and divided for histology and mRNA analyses using real-time quantitative polymerase chain reaction arrays to profile expression at the tissue-mesh interface. Monofilament PE elicited a reduced foreign body reaction compared to multifilament PE, corresponding with reduced mRNA expression of important inflammatory cytokines and matrix metalloproteinases (MMPs). Unexpectedly, monofilament PE also resulted in markedly reduced mRNA expression of tumor necrosis factor and MMPs 3 and 9 compared to the widely-used monofilament PP mesh. Findings from this study revealed that both chemical composition and filament structure are important mesh characteristics that may affect a patient's wound healing response and clinical outcome, and should be considered by the surgeon when choosing a particular mesh. Although clinical studies are warranted, results in a rodent model suggest that monofilament PE may be more beneficial than the multifilament form for certain hernia repairs. C1 [Pierce, Lisa M.] Tripler Army Med Ctr, Dept Clin Invest, Honolulu, HI 96859 USA. [Nguyen, Phuoc T.; Asarias, Jennifer R.] Tripler Army Med Ctr, Dept Gen Surg, Honolulu, HI 96859 USA. RP Pierce, LM (reprint author), Tripler Army Med Ctr, Dept Clin Invest, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM Lisa.Pierce@amedd.army.mil FU Victoria S. and Bradley L. Geist Foundation FX This research was funded by a Victoria S. and Bradley L. Geist Foundation grant awarded to L.P. NR 36 TC 10 Z9 10 U1 2 U2 3 PU INFORMA HEALTHCARE PI LONDON PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND SN 0894-1939 J9 J INVEST SURG JI J. Invest. Surg. PD OCT PY 2012 VL 25 IS 5 BP 330 EP 339 DI 10.3109/08941939.2011.639848 PG 10 WC Surgery SC Surgery GA 015NB UT WOS:000309452000009 PM 22571739 ER PT J AU Crowell, MS Tragord, BS Taylor, AL Deyle, GD AF Crowell, Michael S. Tragord, Bradley S. Taylor, Alden L. Deyle, Gail D. TI Integration of Critically Appraised Topics Into Evidence-Based Physical Therapist Practice SO JOURNAL OF ORTHOPAEDIC & SPORTS PHYSICAL THERAPY LA English DT Article DE critically appraised topic; evidence-based practice; screening ID DEEP-VEIN THROMBOSIS; UNITED-STATES; CT; OSTEOPOROSIS; UROLITHIASIS; ARTHRITIS; GOUT; CARE AB Physical therapists frequently encounter situations that require complex differential-diagnosis decisions and the ability to consistently screen for serious pathology that may mimic a musculoskeletal complaint. By applying the evidence-based-practice process to diagnosis, screening, and referral, physical therapists can identify diagnostic and screening strategies that positively influence clinical decisions. A critically appraised topic document (a standard 1-page summary of the literature appraisal and clinical relevance in response to a specific clinical question) is a valuable tool in evidence-based practice. The creation of a critically appraised topic makes the educational process cumulative instead of duplicative, allowing the individual clinician to assimilate and consolidate knowledge after a search effort and improving search and appraisal skills. The purpose of this clinical commentary is as follows: (1) to describe the clinical reasoning process of 3 orthopaedic physical therapists that led to the development of specific clinical questions related to screening for nonmusculoskeletal pathology, (2) to describe the search and triage strategy that led each physical therapist to the current best evidence needed to rule out nonmusculoskeletal pathology in the patient, and (3) to discuss the advantages and disadvantages of a critically appraised topic, the implementation of this process, and the tailoring of search strategies to find diagnostic and screening strategies. C1 [Crowell, Michael S.; Tragord, Bradley S.; Taylor, Alden L.; Deyle, Gail D.] Baylor Univ, USA, Brooke Army Med Ctr, Ft Sam Houston, TX USA. RP Crowell, MS (reprint author), 131 Amer Flag, Cibolo, TX 78108 USA. EM michael.crowell2@us.army.mil NR 37 TC 2 Z9 2 U1 0 U2 8 PU J O S P T, PI ALEXANDRIA PA 1111 NORTH FAIRFAX ST, STE 100, ALEXANDRIA, VA 22314-1436 USA SN 0190-6011 J9 J ORTHOP SPORT PHYS JI J. Orthop. Sports Phys. Ther. PD OCT PY 2012 VL 42 IS 10 BP 870 EP 879 DI 10.2519/jospt.2012.4265 PG 10 WC Orthopedics; Rehabilitation; Sport Sciences SC Orthopedics; Rehabilitation; Sport Sciences GA 016AL UT WOS:000309489500006 PM 22814199 ER PT J AU Kardouni, JR AF Kardouni, Joseph R. TI Distal Fibula Fracture Diagnosed With Ultrasound Imaging SO JOURNAL OF ORTHOPAEDIC & SPORTS PHYSICAL THERAPY LA English DT Editorial Material C1 [Kardouni, Joseph R.] USA, Washington, DC 20310 USA. [Kardouni, Joseph R.] Virginia Commonwealth Univ, Dept Phys Therapy, Richmond, VA USA. RP Kardouni, JR (reprint author), USA, Washington, DC 20310 USA. NR 2 TC 1 Z9 1 U1 0 U2 2 PU J O S P T, PI ALEXANDRIA PA 1111 NORTH FAIRFAX ST, STE 100, ALEXANDRIA, VA 22314-1436 USA SN 0190-6011 J9 J ORTHOP SPORT PHYS JI J. Orthop. Sports Phys. Ther. PD OCT PY 2012 VL 42 IS 10 BP 887 EP 887 DI 10.2519/jospt.2012.0418 PG 1 WC Orthopedics; Rehabilitation; Sport Sciences SC Orthopedics; Rehabilitation; Sport Sciences GA 016AL UT WOS:000309489500009 PM 23023064 ER PT J AU Underwood, JH Keating, JJ Troiano, E Vigilante, GN AF Underwood, John H. Keating, John J. Troiano, Edward Vigilante, Gregory N. TI Paris Fatigue Life Modeling of Pressure Vessel Service Simulation Tests SO JOURNAL OF PRESSURE VESSEL TECHNOLOGY-TRANSACTIONS OF THE ASME LA English DT Article AB Results from four groups of full-scale pressure vessel service simulation tests are described and analyzed using Paris fatigue life modeling. The objective is to determine how the vessel and initial crack configurations and applied and residual stresses control the as-tested fatigue life of the vessel. The tube inner radii are in the 40-80 mm range; wall thickness varies from 6 to 80 mm; materials are ASTM A723 pressure vessel steel and IN718 nickel-base alloy; applied internal pressure varies from 90 to 700 MPa. The Paris constant, C, and exponent, m, that describe the fatigue crack propagation rate versus stress intensity factor range for the various vessel materials, were measured as part of the investigation. Extensive, previously published fatigue life results from baseline A723 pressure vessels with well characterized autofrettage residual stresses and C and m values are used to demonstrate that a Paris fatigue life model gives a good description of the measured life. The same model is then used to determine the variables with predominant control over life in three types of pressure vessel for which less information and tests results are available. A design life for pressure vessels is calculated for a specified very low probability of fatigue failure using the log(N)-normal distribution statistics often used for fatigue of structures. The results of the work showed: (i) X-ray diffraction measurements of through-wall autofrettage residual stresses are in excellent agreement with prior neutron diffraction measurements from a baseline autofrettaged A723 pressure vessel; these verified autofrettage residual stresses then provide critical input to the baseline Paris life modeling; (ii) comparison of the various full-scale fatigue test results with results from the Paris fatigue life model shows close agreement when autofrettage residual stresses are incorporated into models; (iii) model results for A723 steel vessels with yield strength reduced from the initial 1400 MPa value and degree of autofrettage increased from the initial 40% value indicates a significantly improved resistance to brittle failure with no loss of fatigue life; (iv] comparison of model fatigue life results for IN718 nickel-base alloy vessels with their full-scale test results is improved when near-bore residual stresses measured by X-ray diffraction are included in the model calculations. [DOI: 10.1115/1.4006908] C1 [Underwood, John H.; Keating, John J.; Troiano, Edward; Vigilante, Gregory N.] USA, Benet Labs, Watervliet, NY 12189 USA. RP Underwood, JH (reprint author), USA, Benet Labs, Watervliet, NY 12189 USA. EM treaclemine@hughes.net; john.j.keating.civ@mail.mil; edward.j.troiano.civ@mail.mil; gregory.n.vigilante.civ@mail.mil FU RDECOM-ARDEC: Armaments Research, Development and Engineering Center under the U.S. Army Research Office [W911NF-11-D-0001] FX The authors would like to acknowledge Anthony P. Parker of the UK University of Cranfield for helpful discussions related to the modeling in this work, and Thomas Gabriel of U.S. Army Benet Laboratories for providing results of safe life simulation tests of pressure vessels. We acknowledge support from the RDECOM-ARDEC: Armaments Research, Development and Engineering Center under the auspices of the U.S. Army Research Office Scientific Services Program administered by Battelle (Delivery Order 0045, Contract No. W911NF-11-D-0001). NR 10 TC 0 Z9 0 U1 0 U2 11 PU ASME-AMER SOC MECHANICAL ENG PI NEW YORK PA THREE PARK AVE, NEW YORK, NY 10016-5990 USA SN 0094-9930 J9 J PRESS VESS-T ASME JI J. Press. Vessel Technol.-Trans. ASME PD OCT PY 2012 VL 134 IS 5 AR 051401 DI 10.1115/1.4006908 PG 6 WC Engineering, Mechanical SC Engineering GA 015DF UT WOS:000309425000007 ER PT J AU Malinovsky, VS Donskoy, DM AF Malinovsky, Vladimir S. Donskoy, Dimitri M. TI Electro-magnetically controlled acoustic metamaterials with adaptive properties SO JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA LA English DT Article DE acoustic materials; acoustic resonance; acoustic waves; metamaterials; nanoparticles; structural acoustics; vibrations ID NEGATIVE REFRACTION AB A design of actively controlled metamaterial is proposed and discussed. The metamaterial consists of layers of electrically charged nano or micro particles exposed to external magnetic field. The particles are also attached to compliant layers in a way that the designed structure exhibits two resonances: mechanical spring-mass resonance and electro-magnetic cyclotron resonance. It is shown that if the cyclotron frequency is greater than the mechanical resonance frequency, the designed structure could be highly attenuative (40-60 dB) for vibration and sound waves in very broad frequency range even for wavelength much greater than the thickness of the metamaterial. The approach opens up wide range of opportunities for design of adaptively controlled acoustic metamaterials by controlling magnetic field and/or electrical charges. (C) 2012 Acoustical Society of America. [http://dx.doi.org/10.1121/1.4744943] C1 [Malinovsky, Vladimir S.] Stevens Inst Technol, Dept Phys & Engn Phys, Hoboken, NJ 07030 USA. [Donskoy, Dimitri M.] Stevens Inst Technol, Davidson Lab, Hoboken, NJ 07030 USA. RP Malinovsky, VS (reprint author), USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM vsmalinovsky@gmail.com NR 24 TC 5 Z9 5 U1 2 U2 34 PU ACOUSTICAL SOC AMER AMER INST PHYSICS PI MELVILLE PA STE 1 NO 1, 2 HUNTINGTON QUADRANGLE, MELVILLE, NY 11747-4502 USA SN 0001-4966 EI 1520-8524 J9 J ACOUST SOC AM JI J. Acoust. Soc. Am. PD OCT PY 2012 VL 132 IS 4 BP 2866 EP 2872 DI 10.1121/1.4744943 PN 2 PG 7 WC Acoustics; Audiology & Speech-Language Pathology SC Acoustics; Audiology & Speech-Language Pathology GA 018HU UT WOS:000309651700012 PM 23039553 ER PT J AU Omelchenko, IV Shishkin, OV Gorb, L Hill, FC Leszczynski, J AF Omelchenko, Irina V. Shishkin, Oleg V. Gorb, Leonid Hill, Frances C. Leszczynski, Jerzy TI Properties, aromaticity, and substituents effects in poly nitro- and amino-substituted benzenes SO STRUCTURAL CHEMISTRY LA English DT Article DE Aromaticity; Push-pull effect; Intramolecular hydrogen bond; Quantum chemical calculations ID PI-ELECTRON DELOCALIZATION; CHARGE-TRANSFER CONTRIBUTIONS; MOLECULAR-STRUCTURE; PARA-NITROANILINE; GAS-PHASE; INTERNAL-ROTATION; CRYSTAL-STRUCTURE; HYDROGEN-TRANSFER; GASEOUS-PHASE; H-BOND AB Geometrical parameters, aromaticity, and conformational flexibility of the set of polysubstituted benzenes with different number and position of nitro and amino groups were calculated at the MP2/cc-pvdz level of theory. The key factor for structural and energetic changes has been identified. This is related to the presence of nitro and amino groups in vicinal positions that forms strong intramolecular resonance-assisted hydrogen bonds with a binding energy of 7-14 kcal/mol. Increasing number of such bonds facilitates a cooperative effect, inducing notable changes in molecular geometry (particularly increasing bond alternation within H2N-C-C-NO2 fragment and planarization of amino group), drastic increasing of conformational flexibility and decreasing of aromaticity. In spite of well-known pi-electron effects of nitro and amino substituents, influence of their push-pull interaction through aromatic moiety is negligible compared to the effect of the hydrogen bonding. That results in great difference of the ortho-isomers as compared to meta- and para-isomers. C1 [Omelchenko, Irina V.; Shishkin, Oleg V.] Natl Acad Sci Ukraine, STC Inst Single Crystals, UA-61001 Kharkov, Ukraine. [Shishkin, Oleg V.] Kharkov Natl Univ, UA-61077 Kharkov, Ukraine. [Gorb, Leonid] Badger Tech Serv LLC, Vicksburg, MS USA. [Hill, Frances C.; Leszczynski, Jerzy] USA, ERDC, Vicksburg, MS 39180 USA. [Leszczynski, Jerzy] Jackson State Univ, Dept Chem & Biochem, Interdisciplinary Ctr Nanotox, Jackson, MS 39217 USA. RP Omelchenko, IV (reprint author), Natl Acad Sci Ukraine, STC Inst Single Crystals, 60 Lenina Ave, UA-61001 Kharkov, Ukraine. EM irina@xray.isc.kharkov.com OI Omelchenko, Iryna/0000-0002-6882-6832 FU United States Army Corps of Engineers by the USAERDC FX The use of trade, product, or firm names in this report is for descriptive purposes only and does not imply endorsement by the U.S. Government. Results in this study were funded and obtained from research conducted under the Environmental Quality Technology Program of the United States Army Corps of Engineers by the USAERDC. Permission was granted by the Chief of Engineers to publish this information. The findings of this report are not to be construed as an official Department of the Army position unless so designated by other authorized documents. NR 77 TC 13 Z9 14 U1 3 U2 21 PU SPRINGER/PLENUM PUBLISHERS PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1040-0400 J9 STRUCT CHEM JI Struct. Chem. PD OCT PY 2012 VL 23 IS 5 BP 1585 EP 1597 DI 10.1007/s11224-012-9971-8 PG 13 WC Chemistry, Multidisciplinary; Chemistry, Physical; Crystallography SC Chemistry; Crystallography GA 014BD UT WOS:000309349200032 ER PT J AU Thompson, MG Corey, BW Si, YZ Craft, DW Zurawski, DV AF Thompson, Mitchell G. Corey, Brendan W. Si, Yuanzheng Craft, David W. Zurawski, Daniel V. TI Antibacterial Activities of Iron Chelators against Common Nosocomial Pathogens SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY LA English DT Article ID INFECTIOUS-DISEASES SOCIETY; IN-VITRO; DEFERASIROX; GROWTH; INHIBITION; THIOSEMICARBAZONE; IDENTIFICATION; DEFEROXAMINE; DEFERIPRONE; RESISTANT AB The activities of iron chelators (deferoxamine, deferiprone, Apo6619, and VK28) were evaluated against type strains of Acinetobacter baumannii, Pseudomonas aeruginosa, Staphylococcus aureus, Klebsiella pneumoniae, and Escherichia coli. Deferiprone, Apo6619, and VK28 each inhibited growth in standard and RPMI tissue culture medium, while deferoxamine had no effect. Additionally, time-kill assays revealed that VK28 had a bacteriostatic effect against S. aureus. Therefore, these newly developed iron chelators might provide a nontraditional approach for treatment of bacterial infections. C1 [Thompson, Mitchell G.; Corey, Brendan W.; Si, Yuanzheng; Craft, David W.; Zurawski, Daniel V.] Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. RP Zurawski, DV (reprint author), Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. EM daniel.zurawski@amedd.army.mil RI Zurawski, Daniel/B-6578-2009 OI Zurawski, Daniel/0000-0002-7920-5601 NR 27 TC 24 Z9 25 U1 0 U2 14 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0066-4804 J9 ANTIMICROB AGENTS CH JI Antimicrob. Agents Chemother. PD OCT PY 2012 VL 56 IS 10 BP 5419 EP 5421 DI 10.1128/AAC.01197-12 PG 3 WC Microbiology; Pharmacology & Pharmacy SC Microbiology; Pharmacology & Pharmacy GA 006GQ UT WOS:000308807900058 PM 22850524 ER PT J AU Strohbach, CA Scofield, DE Nindl, BC Centi, AJ Yanovich, R Evans, RK Moran, DS AF Strohbach, C. A. Scofield, D. E. Nindl, B. C. Centi, A. J. Yanovich, R. Evans, R. K. Moran, D. S. TI Female recruits sustaining stress fractures during military basic training demonstrate differential concentrations of circulating IGF-I system components: A preliminary study SO GROWTH HORMONE & IGF RESEARCH LA English DT Article DE Stress fracture; Military physical training; Insulin-like growth factor-I; Insulin-like growth factor binding protein ID BONE-MINERAL DENSITY; GROWTH-FACTOR-I; POSTMENOPAUSAL WOMEN; BODY-COMPOSITION; BINDING-PROTEINS; TRANSGENIC MICE; GENDER-DIFFERENCES; INFANTRY RECRUITS; PHYSICAL-ACTIVITY; SERUM-LEVELS AB Objective: Stress fracture injuries sustained during military basic combat training (BT) are a significant problem and occur at a higher rate in female recruits than male recruits. Insulin-like growth factor-I (IGF-I) is an easily measured biomarker that is involved in bone formation and positively correlated with bone mineral density, especially in women. This study examined the response of the IGF-I system between female soldiers that sustained a stress fracture (SFX, n = 13) during BT and female soldiers who did not (NSFX, n = 49). Design: Female soldiers (n = 62, 18.8 +/- 0.6 yr) from 2 companies of a gender-integrated combat battalion in the Israeli Defense Forces participated in this study. Height; weight and blood draws were taken upon entry to BT (preBT) and after a four-month BT program (postBT). Stress fractures were diagnosed by bone scan. Serum was analyzed for total IGF-I, free IGF-I, IGF binding proteins (IGFBP)1-6, BAP, calcium, CTx, IL1 beta, IL6, PINP, PTH, TNF alpha, TRAP, and 25(OH)D. Statistical differences between SEX and NSFX groups and time points were assessed by RM ANOVA with Fisher post-hoc (p <= 0.05). Results: The SFX group was significantly taller and had lower BMI than NSFX (p <= 0.05). Serum concentrations of total IGF-I, bioavailable IGF-I, other bone biomarkers, and cytokines were not significantly different between SFX and NSFX preBT. Serum IGFBP-2 and IGFBP-5 were significantly higher in the SFX compared to the NSFX preBT (p 0.05). In both groups, total IGF-I increased pre to postBT (p <= 0.05). Additionally, a significant difference was observed in the bioavailable IGF-I response pre to postBT for both groups. The SEX group demonstrated a significant decrease in bioavailable IGF-I pre to postBT (preBT: 0.58 +/- 0.58 ng/mL; postBT 0.39 +/- 0.48; p <= 0.05) whereas the NSFX group demonstrated a significant increase in bioavailable IGF-I pre to postBT (preBT: 0.53 +/- 0.37 ng/mL; postBT: 0.63 +/- 0.45: p <= 0.05). Conclusions: Our study demonstrated that serum IGF-I changes during basic training and that women sustaining stress fractures during BT significantly decreased bioavailable IGF-I, whereas their uninjured counter parts increased bioavailable IGF-I. These results suggest that stress fracture susceptibility may be related to differential IGF-I system concentrations and response to physical training. Published by Elsevier Ltd. C1 [Strohbach, C. A.; Scofield, D. E.; Nindl, B. C.; Centi, A. J.; Evans, R. K.] USA, Mil Performance Div, Environm Med Res Inst, Natick, MA 01760 USA. [Yanovich, R.; Moran, D. S.] Chaim Sheba Med Ctr, Heller Inst Med Res, IL-52621 Tel Hashomer, Israel. [Moran, D. S.] Ariel Univ, Ctr Samaria, IL-40700 Ariel, Israel. RP Strohbach, CA (reprint author), Brooke Army Med Ctr, Dept Clin Investigat, 3400 Rawley E Chambers Ave, Ft Sam Houston, TX 78234 USA. EM cassi.strohbach@us.army.mil RI SCOFIELD, DENNIS/F-3636-2015 FU Heller Institute FX The authors would like to acknowledge the soldier volunteers who participated in this study and the IDF who provided access to potential volunteers. We also thank the Heller Institute for their research support and Dr. Ronald W. Matheny Jr. for assistance and expertise preparation of this manuscript. NR 53 TC 5 Z9 5 U1 2 U2 11 PU CHURCHILL LIVINGSTONE PI EDINBURGH PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE, LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND SN 1096-6374 J9 GROWTH HORM IGF RES JI Growth Horm. IGF Res. PD OCT PY 2012 VL 22 IS 5 BP 151 EP 157 DI 10.1016/j.ghir.2012.04.007 PG 7 WC Cell Biology; Endocrinology & Metabolism SC Cell Biology; Endocrinology & Metabolism GA 007OM UT WOS:000308898000001 PM 22704365 ER PT J AU Haynes, RA Armanios, EA AF Haynes, Robert A. Armanios, Erian A. TI The challenge of achieving hygrothermal stability in composite laminates with optimal couplings SO INTERNATIONAL JOURNAL OF ENGINEERING SCIENCE LA English DT Article DE Laminated composites; Extension-twist coupling; Bend-twist coupling; Hygrothermal stability; Classical lamination theory; Optimization ID FAMILIES AB The necessary and sufficient conditions for hygrothermal curvature stability of composite laminates have been derived previously, and their development is summarized in this work. These conditions are shown to be material independent. A constrained optimization routine is implemented to arrive at hygrothermally stable stacking sequences that are optimal for each of bend-twist and extension-twist coupling. The necessary and sufficient conditions for hygrothermal stability are used as constraints, while the compliance coefficients from classical lamination Theory are used as the objective functions. Both sequential quadratic programming and ant-colony optimization routines are used to ensure global optimality. Laminates consisting of two through ten plies are considered. Laminates consisting of five through ten plies are manufactured and tested to demonstrate the achievable level of extension-twist or bend twist coupling. A geometrically nonlinear model is presented to predict the response of bend-twist-coupled laminates. Comparison with the previous state-of-the-art stacking sequence for achieving extension-twist coupling with hygrothermal stability demonstrates a nearly 80% increase in the level of coupling. (c) 2012 Elsevier Ltd. All rights reserved. C1 [Haynes, Robert A.; Armanios, Erian A.] USA, Res Lab, RDRL VTM, Flare Loop Aberdeen Prov, MD 21005 USA. RP Haynes, RA (reprint author), USA, Res Lab, RDRL VTM, Bldg 4603,Rm 216-08A 4603, Flare Loop Aberdeen Prov, MD 21005 USA. EM robert.haynes@gatech.edu; armanios@uta.edu NR 8 TC 1 Z9 1 U1 0 U2 4 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0020-7225 J9 INT J ENG SCI JI Int. J. Eng. Sci. PD OCT PY 2012 VL 59 SI SI BP 74 EP 82 DI 10.1016/j.ijengsci.2012.03.013 PG 9 WC Engineering, Multidisciplinary SC Engineering GA 989ZI UT WOS:000307600400006 ER PT J AU Lux, S Johnson, K Josefik, N AF Lux, Scott Johnson, Kelsey Josefik, Nicholas TI Component Failure Analysis From a Stationary Proton Exchange Membrane Fuel Cell Demonstration SO JOURNAL OF FUEL CELL SCIENCE AND TECHNOLOGY LA English DT Article ID DEGRADATION; DURABILITY AB A fleet of 91 residential-scale proton exchange membrane (PEM) fuel cells, ranging in size from 1 to 5 kW, was demonstrated at various U. S. federal facilities worldwide. This detailed analysis looks into the most prevalent means of failure in the PEM fuel cell systems as categorized from the stack, reformer, and power conditioning systems as well as the subsequent subsystems. Also evaluated are the lifespan and failure modes of selected fuel cell components, based on component type, age, and usage. The balance of plant, with the numerous pumps and filters, accounted for 60.6% of the total component outages, followed by the fuel cell stack system (20.4%), fuel processing system (10.7%), and the power conditioning system (8.2%). Hydrogen cartridges were the most prevalent component replaced (79), but various filters (RO, DI, air-intake, carbon) account for almost 25% (175) of the total component outages. The natural gas fuel cell stacks had the highest average operational lifetime; one stack reached a total of 10,250 h. [DOI: 10.1115/1.4007116] C1 [Lux, Scott; Johnson, Kelsey; Josefik, Nicholas] USA, Engn Res & Dev Ctr, Construct Engn Res Lab, Champaign, IL 61822 USA. RP Lux, S (reprint author), USA, Engn Res & Dev Ctr, Construct Engn Res Lab, Champaign, IL 61822 USA. EM Scott.M.Lux@usace.army.mil; Kelsey.J.Johnson@usace.army.mil; Nicholas.M.Josefik@usace.army.mil NR 12 TC 1 Z9 1 U1 0 U2 9 PU ASME-AMER SOC MECHANICAL ENG PI NEW YORK PA THREE PARK AVE, NEW YORK, NY 10016-5990 USA SN 1550-624X J9 J FUEL CELL SCI TECH JI J. Fuel Cell Sci. Technol. PD OCT PY 2012 VL 9 IS 5 AR 051007 DI 10.1115/1.4007116 PG 7 GA 000RX UT WOS:000308406800007 ER PT J AU Grujicic, M Arakere, G Pandurangan, B Yen, CF Cheeseman, BA AF Grujicic, Mica Arakere, G. Pandurangan, B. Yen, C. -F. Cheeseman, B. A. TI Process Modeling of Ti-6Al-4V Linear Friction Welding (LFW) SO JOURNAL OF MATERIALS ENGINEERING AND PERFORMANCE LA English DT Article DE linear friction welding; process modeling; Ti-6Al-4V; weld microstructure/properties prediction ID MICROSTRUCTURE EVOLUTION; MECHANICAL-PROPERTIES; WELDED 45-STEEL; ALLOY; AA5083 AB A fully coupled thermomechanical finite-element analysis of the linear friction welding (LFW) process is combined with the basic physical metallurgy of Ti-6Al-4V to predict microstructure and mechanical properties within the LFW joints (as a function of the LFW process parameters). A close examination of the experimental results reported in the open literature revealed that the weld region consists of a thermomechanically affected zone (TMAZ) and a heat-affected zone (HAZ) and that the material mechanical properties are somewhat more inferior in the HAZ. Taking this observation into account, a model for microstructure-evolution during LFW was developed and parameterized for the Ti-6Al-4V material residing in the HAZ. Specifically, this model addresses the problem of temporal evolution of the prior beta-phase grain size (the dominant microstructural parameter in the HAZ) during the LFW process. This model is next combined with the well-established property versus microstructure correlations in Ti-6Al-4V to predict the overall structural performance of the LFW joint. The results obtained are found to be in reasonably good agreement with their experimental counterparts suggesting that the present computational approach may be used to guide the selection of the LFW process parameters to optimize the structural performance of the LFW joints. C1 [Grujicic, Mica; Arakere, G.; Pandurangan, B.] Clemson Univ, Dept Mech Engn, Clemson, SC 29634 USA. [Yen, C. -F.; Cheeseman, B. A.] USA, Res Lab, Survivabil Mat Branch, Aberdeen Proving Ground, MD 21005 USA. RP Grujicic, M (reprint author), Clemson Univ, Dept Mech Engn, 241 Engn Innovat Bldg, Clemson, SC 29634 USA. EM gmica@clemson.edu FU Army Research Office [W911NF-11-1-0207, W911NF-09-1-0513]; U.S. Army/Clemson University [W911NF-04-2-0024, W911NF-06-2-0042] FX The research material presented in this article is based on study supported by two Army Research Office sponsored grants (W911NF-11-1-0207 and W911NF-09-1-0513), and two U.S. Army/Clemson University Cooperative Agreements (W911NF-04-2-0024 and W911NF-06-2-0042). NR 34 TC 11 Z9 11 U1 0 U2 23 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1059-9495 J9 J MATER ENG PERFORM JI J. Mater. Eng. Perform. PD OCT PY 2012 VL 21 IS 10 BP 2011 EP 2023 DI 10.1007/s11665-011-0097-8 PG 13 WC Materials Science, Multidisciplinary SC Materials Science GA 010OG UT WOS:000309103200001 ER PT J AU Baulesh, DM Huh, J Judkins, T Garg, S Miller, NH Erickson, MA AF Baulesh, David M. Huh, Jeannie Judkins, Timothy Garg, Sumeet Miller, Nancy H. Erickson, Mark A. TI The Role of Serial Casting in Early-onset Scoliosis (EOS) SO JOURNAL OF PEDIATRIC ORTHOPAEDICS LA English DT Article DE scoliosis; early-onset scoliosis (EOS); nonsurgical scoliosis treatment; serial casting ID PROGRESSIVE INFANTILE SCOLIOSIS; THORACIC INSUFFICIENCY SYNDROME; GROWTH; COMPLICATIONS; CHILDREN; FUSION AB Background: Serial casting has demonstrated efficacy for idiopathic early-onset scoliosis (EOS). Results of casting in nonidiopathic (syndromic and congenital) EOS patients have not previously been well described. Methods: A total of 53 patients underwent serial casting for EOS from 2005 to 2010 at a single institution. Deformity was classified as idiopathic or nonidiopathic. Diagnosis, time in cast, number of casts, use of bracing, complications, and outcomes were recorded. Radiographic measures included Cobb angle and thoracic height (T1-T12). Thoracic height velocity was calculated and compared with established norms. Results: A total of 36 patients, 19 idiopathic and 17 nonidiopathic (14 syndromic, 3 congenital), completed cast treatment and had >6-month follow-up and were therefore included. Of those, 17% (6/36) experienced resolution of their deformity, 53% (19/26) are currently in braces, and 31% (11/36) had undergone surgery. Surgery occurred on average at age 5.6 years and was delayed by an average of 2.1 years from time of first cast. A 19% complication was observed. There was no statistical difference in the rate of resolution of deformity between idiopathic (5/19) and nonidiopathic (1/17) patients (P = 0.182), although there exists a trend toward greater curve correction in idiopathic patients. Surgery occurred in fewer patients (2/19) in the idiopathic group compared with the nonidiopathic group (9/17) (P = 0.006). Significant improvements in Cobb angle was observed in the idiopathic group (12.2 degrees) during casting (P = 0.003). Nonidiopathic patients did not maintain the correction gained during casting at the time of final follow-up. T1-T12 height increased across all study patients regardless of etiology during the period of casting at similar velocity to established norms of 1.4 cm/y for this age group. Conclusions: Serial casting offers modest deformity correction in idiopathic deformities compared with nonidiopathic deformities. Thoracic height growth continued throughout the casting period at normal velocity. Serial casting maintained normal longitudinal thoracic growth in all patients with EOS in this cohort. Although many required surgery, the increased thoracic height may have positive implications on ultimate pulmonary function. Level of Evidence: Therapeutic level III. C1 [Huh, Jeannie] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. [Baulesh, David M.; Judkins, Timothy; Garg, Sumeet; Miller, Nancy H.; Erickson, Mark A.] Childrens Hosp, Dept Orthopaed Surg, Aurora, CO USA. [Garg, Sumeet; Miller, Nancy H.; Erickson, Mark A.] Univ Colorado, Dept Orthoped Surg, Denver, CO 80202 USA. RP Huh, J (reprint author), Brooke Army Med Ctr, Bldg 3600,3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM jeannie.huh@amedd.army.mil OI Garg, Sumeet/0000-0003-1703-0276 NR 14 TC 11 Z9 12 U1 0 U2 8 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0271-6798 EI 1539-2570 J9 J PEDIATR ORTHOPED JI J. Pediatr. Orthop. PD OCT-NOV PY 2012 VL 32 IS 7 BP 658 EP 663 DI 10.1097/BPO.0b013e318269c438 PG 6 WC Orthopedics; Pediatrics SC Orthopedics; Pediatrics GA 006HW UT WOS:000308811100006 PM 22955527 ER PT J AU Firoz, BF Henning, JS Zarzabal, LA Pollock, BH AF Firoz, Bahar F. Henning, Jeffrey Scott Zarzabal, Lee Ann Pollock, Brad H. TI Toxic epidermal necrolysis: Five years of treatment experience from a burn unit SO JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY LA English DT Article ID STEVENS-JOHNSON-SYNDROME; INTRAVENOUS IMMUNOGLOBULIN; CYCLOSPORINE; SCORTEN; MORTALITY; DEATH AB Background: Toxic epidermal necrolysis (TEN) is a serious drug eruption that results in death in approximately 25% to 50% of patients. There is controversy over whether SCORTEN accurately predicts mortality or if treatment interventions such as intravenous immunoglobulin (IVIg) can alter mortality. Objectives: We sought to determine whether SCORTEN accurately predicts mortality in this cohort, whether IVIg improved survival, and which drugs and medical comorbidities impacted mortality. Methods: We summarize our experience prospectively over 5 years and 82 patients. Patients either received supportive care, intravenous immunoglobulin, or cyclosporine as treatment. All patients had a SCORTEN on admission, an offending drug on record, and a list of medical comorbidities. Results: Of the 82 patients, 29% died from TEN. SCORTEN accurately predicted mortality in this cohort with an area under the curve (AUC) of 0.83 in a receiver operator curve (ROC) analysis. A Kaplan-Meier curve did not show improved mortality if patients received IVIg versus supportive care (P = .9). Medications most often responsible for TEN were trimethoprim/sulfamethoxazole, followed by anticonvulsants, nonsteroidal anti-inflammatories, and allopurinol. Limitations: This prospective cohort study design is not as ideal as patients presenting for a randomized controlled trial. Conclusions: SCORTEN was an accurate predictor of mortality in this cohort. Age older than 40 years, the presence of metabolic syndrome and/or gout, higher body surface area involvement, higher SCORTEN, and higher number of medical comorbidities statistically significantly increased risk of death. IVIg did not significantly alter mortality. Although the highest number of cases was due to trimethoprim/sulfamethoxazole, the greatest proportion of deaths was due to allopurinol. (J Am Acad Dermatol 2012;67:630-5.) C1 [Firoz, Bahar F.] Univ Texas Hlth Sci Ctr San Antonio, Div Dermatol, San Antonio, TX 78229 USA. [Zarzabal, Lee Ann; Pollock, Brad H.] Univ Texas Hlth Sci Ctr San Antonio, Dept Epidemiol & Biostat, San Antonio, TX 78229 USA. [Henning, Jeffrey Scott] Brooke Army Med Ctr, Dept Dermatol, San Antonio, TX USA. RP Firoz, BF (reprint author), CTRC, Dept Med, Div Dermatol MC 7876, 7979 Wurzbach,3rd Floor Grossman, San Antonio, TX 78229 USA. EM firoz@uthscsa.edu NR 15 TC 21 Z9 23 U1 0 U2 5 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0190-9622 J9 J AM ACAD DERMATOL JI J. Am. Acad. Dermatol. PD OCT PY 2012 VL 67 IS 4 BP 630 EP 635 DI 10.1016/j.jaad.2011.12.014 PG 6 WC Dermatology SC Dermatology GA 011JF UT WOS:000309160200044 PM 22285617 ER PT J AU Xia, Y Cho, SH Howard, RS Maggio, KL AF Xia, Yang Cho, Sunghun Howard, Robin S. Maggio, Kurt L. TI Topical eflornithine hydrochloride improves the effectiveness of standard laser hair removal for treating pseudofolliculitis barbae: A randomized, double-blinded, placebo-controlled trial SO JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY LA English DT Article DE eflornithine hydrochloride; hair laser; pseudofolliculitis barbae ID ND-YAG LASER; SKIN; VI AB Background: Pseudofolliculitis barbae (PFB) significantly impacts the military population, especially deployed personnel. Objective: This study was designed to determine whether the addition of topical eflornithine to hair laser treatment would improve efficacy in treating PFB. Methods: This was a randomized, double-blinded, placebo-controlled, paired (right and left neck) comparison study examining a combination of eflornithine and hair laser versus placebo and hair laser for the treatment of PFB. In all, 27 male patients with clinical PFB were treated with a long-pulsed neodymium: yttrium-aluminum-garnet laser with an energy fluence of 25 to 30 J/cm(2), a pulse duration of 20 to 30 milliseconds, and a 10-mm spot size to the entire bearded neck region. The laser treatment was performed every 4 weeks for a total of 16 weeks. Between laser treatments, patients applied eflornithine and placebo creams twice daily to opposite sides of the bearded neck region. The number of hairs and inflammatory papules were counted bilaterally at each visit. Results: The eflornithine side had a statistically significant decrease in the number of hairs and inflammatory papules compared with the placebo side. At 16 weeks, the eflornithine side had a median hair reduction of 99.5% from baseline (range 48.5%-100.0%), whereas the placebo side had an 85.0% median hair reduction from baseline (range 50.5%-94.5%), P less than .001. Limitations: Patients were not followed up beyond 16 weeks. Conclusion: The addition of topical eflornithine to hair laser treatment decreased hairs and inflammatory papules faster when compared with hair laser therapy alone in the treatment of PFB. (J Am Acad Dermatol 2012;67:694-9.) C1 [Xia, Yang] San Antonio Uniformed Serv Hlth Educ Consortium, Dermatol Serv, San Antonio, TX 78236 USA. [Cho, Sunghun] Dermatol Clin, Grafenwoehr, Germany. [Howard, Robin S.] Walter Reed Army Med Ctr, Dept Clin Invest, Washington, DC 20307 USA. [Maggio, Kurt L.] Walter Reed Army Med Ctr, Dermatol Serv, Washington, DC 20307 USA. RP Xia, Y (reprint author), San Antonio Uniformed Serv Hlth Educ Consortium, Dermatol Serv, 2200 Bergquist Dr,Ste 1, San Antonio, TX 78236 USA. EM yang.xia@us.army.mil NR 9 TC 6 Z9 6 U1 0 U2 2 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0190-9622 J9 J AM ACAD DERMATOL JI J. Am. Acad. Dermatol. PD OCT PY 2012 VL 67 IS 4 BP 694 EP 699 DI 10.1016/j.jaad.2011.10.029 PG 6 WC Dermatology SC Dermatology GA 011JF UT WOS:000309160200053 PM 22226431 ER PT J AU Burgess, EB AF Burgess, Edwin B. TI The Devil's Causeway: The True Story of America's First Prisoners of War in the Phillipines, and the Heroic Expedition Sent to Their Rescue SO LIBRARY JOURNAL LA English DT Book Review C1 [Burgess, Edwin B.] USA, Combined Arms Res Lib, Ft Leavenworth, KS USA. RP Burgess, EB (reprint author), USA, Combined Arms Res Lib, Ft Leavenworth, KS USA. NR 1 TC 0 Z9 0 U1 0 U2 1 PU REED BUSINESS INFORMATION PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010 USA SN 0363-0277 J9 LIBR J JI Libr. J. PD OCT 1 PY 2012 VL 137 IS 16 BP 93 EP 93 PG 1 WC Information Science & Library Science SC Information Science & Library Science GA 013TH UT WOS:000309328300162 ER PT J AU Ridgeway, K Silvernail, J AF Ridgeway, Kyle Silvernail, Jason TI Innominate 3D motion modeling: Biomechanically interesting, but clinically irrelevant SO MANUAL THERAPY LA English DT Letter ID PAIN PROVOCATION TESTS; SACROILIAC JOINT PAIN; LOW-BACK-PAIN; SPINAL MANIPULATION; PREDICTION RULE; RELIABILITY; DIAGNOSIS; VALIDITY; ANATOMY; THERAPY C1 [Ridgeway, Kyle] Univ Colorado Hosp, Aurora, CO USA. [Ridgeway, Kyle] Panther Phys Therapy, Littleton, CO USA. [Ridgeway, Kyle] Univ Colorado Anschutz Med Campus, Sch Med, Phys Therapy Program, Aurora, CO USA. [Silvernail, Jason] USA, El Paso, TX USA. [Silvernail, Jason] Army Baylor Univ, Doctoral Program Orthoped Manual Therapy, Adjunct Fac, San Antonio, TX USA. RP Ridgeway, K (reprint author), 1390 High St 704, Denver, CO 80218 USA. EM kyle.j.ridgeway@gmail.com NR 18 TC 0 Z9 0 U1 0 U2 4 PU CHURCHILL LIVINGSTONE PI EDINBURGH PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE, LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND SN 1356-689X J9 MANUAL THER JI Man. Ther. PD OCT PY 2012 VL 17 IS 5 BP E11 EP E12 DI 10.1016/j.math.2012.02.017 PG 2 WC Rehabilitation SC Rehabilitation GA 012AZ UT WOS:000309209100001 PM 22459603 ER PT J AU Koo, S Sutton, DA Yeh, WW Thompson, EH Sigler, L Shearer, JF Hofstra, DE Wickes, BL Marty, FM AF Koo, Sophia Sutton, Deanna A. Yeh, Wendy W. Thompson, Elizabeth H. Sigler, Lynne Shearer, Judy F. Hofstra, Deborah E. Wickes, Brian L. Marty, Francisco M. TI Invasive Mycoleptodiscus fungal cellulitis and myositis SO MEDICAL MYCOLOGY LA English DT Article DE Mycoleptodiscus; invasive fungal disease; dematiaceous; temozolomide ID PATIENTS RECEIVING TEMOZOLOMIDE; GLIOBLASTOMA-MULTIFORME; DOSE TEMOZOLOMIDE; INDICUS INFECTION; PHEOHYPHOMYCOSIS; LYMPHOPENIA; MELANOMA; THERAPY AB We report progressive necrotizing fungal cellulitis and myositis in the leg of a patient with glioblastoma multiforme treated with temozolomide and corticosteroids. While the morphologic appearance of the isolate and its ability to grow at temperatures greater than 32 degrees C were suggestive of Mycoleptodiscus indicus, some of the conidia were atypical for this species in that they had single septa and occasional lateral appendages. Furthermore, the isolate was different from M. indicus based on the sequencing analysis of two rDNA regions. This is the first case of Mycoleptodiscus invasive fungal disease in which the causative agent could not be resolved at the species level because of inconsistencies between morphological and molecular data. C1 [Koo, Sophia; Yeh, Wendy W.; Marty, Francisco M.] Brigham & Womens Hosp, Div Infect Dis, Boston, MA 02115 USA. [Koo, Sophia; Yeh, Wendy W.; Marty, Francisco M.] Dana Farber Canc Inst, Boston, MA 02115 USA. [Koo, Sophia; Yeh, Wendy W.; Marty, Francisco M.] Harvard Univ, Sch Med, Boston, MA USA. [Sutton, Deanna A.; Thompson, Elizabeth H.; Wickes, Brian L.] Univ Texas Hlth Sci Ctr San Antonio, Dept Pathol, Fungus Testing Lab, San Antonio, TX 78229 USA. [Sigler, Lynne] Univ Alberta Microfungus Collect & Herbarium, Devonian Bot Garden, Edmonton, AB, Canada. [Shearer, Judy F.] USA, Corps Engineers, Engn Res & Dev Ctr, Vicksburg, MS 39180 USA. [Hofstra, Deborah E.] Natl Inst Water & Atmospher Res, Hamilton, New Zealand. RP Koo, S (reprint author), Brigham & Womens Hosp, Div Infect Dis, 75 Francis St,PBB-A4, Boston, MA 02115 USA. EM skoo@partners.org OI Koo, Sophia/0000-0002-4973-7439 NR 26 TC 1 Z9 1 U1 0 U2 2 PU INFORMA HEALTHCARE PI LONDON PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND SN 1369-3786 J9 MED MYCOL JI Med. Mycol. PD OCT PY 2012 VL 50 IS 7 BP 740 EP 745 DI 10.3109/13693786.2012.656717 PG 6 WC Infectious Diseases; Mycology; Veterinary Sciences SC Infectious Diseases; Mycology; Veterinary Sciences GA 008HV UT WOS:000308948900008 PM 22332907 ER PT J AU Hill, OT AF Hill, Owen T. TI Comments to "Rhabdomyolysis in the US Active Duty Army, 2004-2006" RESPONSE SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Letter C1 USA, Environm Med Res Inst, Natick, MA 01760 USA. RP Hill, OT (reprint author), USA, Environm Med Res Inst, Natick, MA 01760 USA. RI Hill, Owen/E-3643-2013 NR 0 TC 0 Z9 0 U1 1 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD OCT PY 2012 VL 44 IS 10 BP 2043 EP 2043 DI 10.1249/MSS.0b013e318267c585 PG 1 WC Sport Sciences SC Sport Sciences GA 010RB UT WOS:000309110700030 ER PT J AU Wang, WY Shang, SL Fang, HZ Zhang, H Wang, Y Mathaudhu, SN Hui, XD Liu, ZK AF Wang, William Yi Shang, Shun Li Fang, Hua Zhi Zhang, Hui Wang, Yi Mathaudhu, Suveen Nigel Hui, Xi Dong Liu, Zi-Kui TI Effects of Composition on Atomic Structure, Diffusivity, and Viscosity of Liquid Al-Zr Alloys SO METALLURGICAL AND MATERIALS TRANSACTIONS A-PHYSICAL METALLURGY AND MATERIALS SCIENCE LA English DT Article; Proceedings Paper CT Hume-Rothery Symposium on Thermodynamics and Diffusion Coupling in Alloys-Application Driven Science CY FEB 27-MAR 03, 2011 CL San Diego, CA ID INITIO MOLECULAR-DYNAMICS; TOTAL-ENERGY CALCULATIONS; AUGMENTED-WAVE METHOD; METALLIC GLASSES; SUPERCOOLED LIQUID; RANGE ORDER; BASIS-SET; TRANSITION; SIMULATION; TEMPERATURE AB The diffusion coefficients and viscosity of four Al1-x Zr (x) (x = 0.4, 0.5. 0.6, and 0.67) alloys are predicted by ab initio molecular dynamic simulations via the Einstein and Darken equations. It is observed that the addition of Zr to Al reduces the self-diffusion coefficient of Al drastically, whereas the addition of Al to Zr has little effect on the self-diffusion coefficient of Zr. The interdiffusion coefficient and viscosity are predicted with both being close to those of pure Al extrapolated to high temperatures. Based on the analysis of atomic structures, the observations are attributed to clustering in liquid so that the migration of Al and Zr are correlated strongly and viscous flow is affected by Al-Al bonding between clusters. C1 [Wang, William Yi; Shang, Shun Li; Fang, Hua Zhi; Zhang, Hui; Wang, Yi; Liu, Zi-Kui] Penn State Univ, Dept Mat Sci & Engn, University Pk, PA 16802 USA. [Wang, William Yi; Hui, Xi Dong] Univ Sci & Technol Beijing, State Key Lab Adv Met & Mat, Beijing 100083, Peoples R China. [Mathaudhu, Suveen Nigel] USA, Div Mat Sci, Res Off, Res Triangle Pk, NC 27709 USA. RP Wang, WY (reprint author), Penn State Univ, Dept Mat Sci & Engn, University Pk, PA 16802 USA. EM yuw129@psu.edu RI Wang, William Yi/F-8212-2011; Hui, Xidong/A-1741-2010; Wang, Yi/D-1032-2013; Shang, Shun-Li/A-6564-2009; Fang, Huazhi/L-6126-2013; Mathaudhu, Suveen/B-4192-2009; Liu, Zi-Kui/A-8196-2009 OI Wang, William Yi/0000-0002-8814-525X; Shang, Shun-Li/0000-0002-6524-8897; Fang, Huazhi/0000-0002-4561-6971; Liu, Zi-Kui/0000-0003-3346-3696 FU U.S. Army Research Lab [W911NF-08-2-0064]; National Science Foundation in the United States [DMR-1006557]; National Natural Science Foundation of China [50431030, 50871013]; National Basic Research Program of China [2007CB613901]; Project Based Personnel Exchange Program; China Scholarship Council; American Academic Exchange Service [[2008]3072]; Materials Simulation Center; Research Computing and Cyberinfrastructure Unit at the Pennsylvania State University; NSF [OCI-0821527] FX This work was supported financially by the U.S. Army Research Lab (Project No. W911NF-08-2-0064) and the National Science Foundation (Grant No. DMR-1006557) in the United States, the National Natural Science Foundation of China (Grant Nos. 50431030 and 50871013), and the National Basic Research Program of China (Grant No. 2007CB613901). W.Y. Wang acknowledges the support from the Project Based Personnel Exchange Program with China Scholarship Council and American Academic Exchange Service ([2008]3072). First-principles calculations were carried out on the LION clusters at the Pennsylvania State University supported by the Materials Simulation Center and the Research Computing and Cyberinfrastructure Unit at the Pennsylvania State University. The calculations were also carried out on the CyberStar cluster funded by NSF through Grant OCI-0821527. NR 53 TC 9 Z9 9 U1 4 U2 38 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1073-5623 EI 1543-1940 J9 METALL MATER TRANS A JI Metall. Mater. Trans. A-Phys. Metall. Mater. Sci. PD OCT PY 2012 VL 43A IS 10 BP 3471 EP 3480 DI 10.1007/s11661-011-1054-8 PG 10 WC Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Materials Science; Metallurgy & Metallurgical Engineering GA 997ST UT WOS:000308187100010 ER PT J AU Kirkup, BC Craft, DW Palys, T Black, C Heitkamp, R Li, C Lu, Y Matlock, N McQueary, C Michels, A Peck, G Si, Y Summers, AM Thompson, M Zurawski, DV AF Kirkup, B. C., Jr. Craft, D. W. Palys, T. Black, C. Heitkamp, R. Li, C. Lu, Y. Matlock, N. McQueary, C. Michels, A. Peck, G. Si, Y. Summers, A. M. Thompson, M. Zurawski, D. V. TI Traumatic Wound Microbiome Workshop SO MICROBIAL ECOLOGY LA English DT Article ID DESORPTION IONIZATION-TIME; FLIGHT MASS-SPECTROMETRY; INTESTINAL MICROBIOTA; BACTERIAL DIVERSITY; RARE BIOSPHERE; GUT MICROBIOTA; IDENTIFICATION; YEAST; RESISTANCE; FLORA AB On May 9-10, 2011, the Walter Reed Army Institute of Research, as the Army Center of Excellence for Infectious Disease, assembled over a dozen leaders in areas related to research into the communities of microorganisms which colonize and infect traumatic wounds. The objectives of the workshop were to obtain guidance for government researchers, to spur research community involvement in the field of traumatic wound research informed by a microbiome perspective, and to spark collaborative efforts serving the Wounded Warriors and similarly wounded civilians. During the discussions, it was made clear that the complexity of these infections will only be met by developing a new art of clinical practice that engages the numerous microbes and their ecology. It requires the support of dedicated laboratories and technologists who advance research methods such as community sequencing, as well as the kinds of data analysis expertise and facilities. These strategies already appear to be bearing fruit in the clinical management of chronic wounds. There are now funding announcements and programs supporting this area of research open to extramural collaborators. C1 [Kirkup, B. C., Jr.; Craft, D. W.; Palys, T.; Black, C.; Heitkamp, R.; Li, C.; Lu, Y.; Matlock, N.; McQueary, C.; Michels, A.; Peck, G.; Si, Y.; Summers, A. M.; Thompson, M.; Zurawski, D. V.] Walter Reed Army Inst Res, Dept Wound Infect, Bacterial Dis Branch, Silver Spring, MD 20910 USA. [Kirkup, B. C., Jr.] Uniformed Serv Univ Hlth Sci, F Edward Hebert Sch Med, Silver Spring, MD 20910 USA. RP Kirkup, BC (reprint author), Walter Reed Army Inst Res, Dept Wound Infect, Bacterial Dis Branch, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM benjamin.kirkup@us.army.mil RI Black, Chad/B-2848-2011; Kirkup, Benjamin/C-3610-2009; OI Kirkup, Benjamin/0000-0002-8722-6218; Zurawski, Daniel/0000-0002-7920-5601 FU Command of the WRAIR FX The Command of the WRAIR, particularly Col. KE Kester, MC, and the Science Director, Dr. MT Vahey, is acknowledged for supporting and financing the workshop. Spc. Saini and Spc. Fly are acknowledged for their logistical support during the conference. NR 47 TC 1 Z9 1 U1 0 U2 12 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0095-3628 J9 MICROB ECOL JI Microb. Ecol. PD OCT PY 2012 VL 64 IS 3 BP 837 EP 850 DI 10.1007/s00248-012-0070-6 PG 14 WC Ecology; Marine & Freshwater Biology; Microbiology SC Environmental Sciences & Ecology; Marine & Freshwater Biology; Microbiology GA 010YZ UT WOS:000309131700024 PM 22622764 ER PT J AU Loyd, DR Sun, XLX Locke, EE Salas, MM Hargreaves, KM AF Loyd, Dayna R. Sun, Xiaoling X. Locke, Erin E. Salas, Margaux M. Hargreaves, Kenneth M. TI Sex differences in serotonin enhancement of capsaicin-evoked calcitonin gene-related peptide release from human dental pulp SO PAIN LA English DT Article DE CGRP; 5HT; Craniofacial; Orofacial; Teeth; Pain ID LINOLEIC-ACID METABOLITES; OROFACIAL PAIN; THERMAL HYPERALGESIA; MENSTRUAL-CYCLE; MIGRAINE; RECEPTOR; RAT; POPULATION; ACTIVATION; HEAT AB Serotonin (5HT) is a pronociceptive mediator in the periphery, and evidence implicates involvement in trigeminal pain processing. However, the mechanism(s) by which 5HT modulates trigeminal nociceptors remains unclear. Trigeminal pain can be evoked by the transient receptor potential V1 channel (TRPV1), which is expressed by nociceptive trigeminal neurons and induces release of proinflammatory calcitonin gene-related peptide (CGRP). In our preclinical models, 5HT evoked thermal hyperalgesia and enhanced calcium influx and CGRP release from the TRPV1 population of trigeminal nociceptors. Whether this occurs in humans is unknown. As dental pulp is densely innervated by trigeminal nociceptors, routine tooth extractions offer a unique opportunity to examine whether 5HT enhances CGRP release from human nociceptors. Pulpal tissue was collected from 140 extracted molar teeth from men and women, and basal release samples were collected before treatment with saline or 5HT 100 mu mol/L. CGRP release was then stimulated with the TRPV1 agonist capsaicin 1 mu mol/L and quantitated by enzyme immunoassay. Additional samples were collected for Western blots to examine 5HT receptor expression. We report that 5HT induced a significant increase in capsaicin-evoked CGRP release, and that this enhancement was observed only in female dental pulp, with no effect of 5HT on male dental pulp. The greatest amount of CGRP release occurred in dental pulp from women in the luteal phase of the menstrual cycle. These results indicate that 5HT enhances capsaicin-evoked CGRP release from human trigeminal nociceptors in a sexually dimorphic manner providing a mechanistic basis for prevalence of trigeminal pain disorders in women. Published by Elsevier B.V. on behalf of International Association for the Study of Pain. C1 [Loyd, Dayna R.; Sun, Xiaoling X.; Locke, Erin E.; Hargreaves, Kenneth M.] Univ Texas Hlth Sci Ctr San Antonio, Dept Endodont, San Antonio, TX 78229 USA. [Salas, Margaux M.; Hargreaves, Kenneth M.] Univ Texas Hlth Sci Ctr San Antonio, Dept Cellular & Struct Biol, San Antonio, TX 78229 USA. [Hargreaves, Kenneth M.] Univ Texas Hlth Sci Ctr San Antonio, Dept Pharmacol, San Antonio, TX 78229 USA. RP Loyd, DR (reprint author), USA, Inst Surg Res, Pain Management Res Area, 3698 Chambers Pass, Ft Sam Houston, TX 78234 USA. EM dayna.l.averitt@us.army.mil OI Averitt, Dayna/0000-0001-8345-4988; Loyd, Dayna/0000-0002-5635-185X FU National Institutes of Health [NCATS UL1TR000149, R01 NS58655, T32 DE14318, F32 DE021309] FX The authors would like to acknowledge the helpful comments of Michael A. Henry, DDS, PhD, and the technical assistance of Paul Chen. This work was supported by National Institutes of Health grants NCATS UL1TR000149 and R01 NS58655 (K. M. H.), T32 DE14318, F32 DE021309 (D.R.L.). NR 46 TC 8 Z9 8 U1 0 U2 6 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0304-3959 J9 PAIN JI Pain PD OCT PY 2012 VL 153 IS 10 BP 2061 EP 2067 DI 10.1016/j.pain.2012.06.018 PG 7 WC Anesthesiology; Clinical Neurology; Neurosciences SC Anesthesiology; Neurosciences & Neurology GA 009WG UT WOS:000309055500014 PM 22819536 ER PT J AU Das, P Densmore, JM Rastovski, C Schlesinger, KJ Laver, M Dewhurst, CD Littrell, K Bud'ko, SL Canfield, PC Eskildsen, MR AF Das, P. Densmore, J. M. Rastovski, C. Schlesinger, K. J. Laver, M. Dewhurst, C. D. Littrell, K. Bud'ko, S. L. Canfield, P. C. Eskildsen, M. R. TI Field dependence of the superconducting basal plane anisotropy of TmNi2B2C SO PHYSICAL REVIEW B LA English DT Article ID SINGLE-CRYSTAL TMNI2B2C; MAGNETIC-STRUCTURE; VORTICES; LATTICE; CORE AB The superconductor TmNi2B2C possesses a significant fourfold basal plane anisotropy, leading to a square vortex lattice (VL) at intermediate fields. However, unlike other members of the borocarbide superconductors, the anisotropy in TmNi2B2C appears to decrease with increasing field, evident by a reentrance of the square VL phase. We have used small-angle neutron scattering measurements of the VL to study the field dependence of the anisotropy. Our results provide a direct, quantitative measurement of the decreasing anisotropy. We attribute this reduction of the basal plane anisotropy to the strong Pauli paramagnetic effects observed in TmNi2B2C and the resulting expansion of vortex cores near H-c2. C1 [Das, P.; Rastovski, C.; Schlesinger, K. J.; Eskildsen, M. R.] Univ Notre Dame, Dept Phys, Notre Dame, IN 46556 USA. [Densmore, J. M.] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. [Laver, M.] Paul Scherrer Inst, Lab Neutron Scattering, CH-5232 Villigen, Switzerland. [Laver, M.] Tech Univ Denmark, Riso DTU, Mat Res Div, DK-4000 Roskilde, Denmark. [Laver, M.] Univ Copenhagen, Niels Bohr Inst, Nano Sci Ctr, DK-2100 Copenhagen, Denmark. [Dewhurst, C. D.] Inst Laue Langevin, F-38042 Grenoble, France. [Littrell, K.] Oak Ridge Natl Lab, Oak Ridge, TN 37831 USA. [Bud'ko, S. L.; Canfield, P. C.] Iowa State Univ, Ames Lab, Ames, IA 50011 USA. [Bud'ko, S. L.; Canfield, P. C.] Iowa State Univ, Dept Phys & Astron, Ames, IA 50011 USA. RP Das, P (reprint author), Univ Notre Dame, Dept Phys, Notre Dame, IN 46556 USA. EM eskildsen@nd.edu RI Densmore, John/G-1228-2011; Das, Pinaki/C-2877-2012; Littrell, Kenneth/D-2106-2013; Canfield, Paul/H-2698-2014 OI Densmore, John/0000-0003-2388-1413; Littrell, Kenneth/0000-0003-2308-8618; FU US National Science Foundation [DMR-0804887]; US Army Research Laboratory Postdoctoral Fellowship Program; Oak Ridge Associated Universities through a contract with the US Army Research Laboratory; Notre Dame Institute for Scholarship in the Liberal Arts; DanScatt; National Institute of Standards and Technology, US Department of Commerce; Scientific User Facilities Division, Office of Basic Energy Sciences, US Department of Energy; US Department of Energy, Office of Basic Energy Science, Division of Materials Sciences and Engineering; Iowa State University [DE-AC02-07CH11358] FX We acknowledge discussions with E. M. Forgan, M. Ichioka, K. Machida, V. P. Michal, V. P. Mineev, and J. S. White. This work was supported by the US National Science Foundation through Grant No. DMR-0804887. J.M.D. was supported in part by an appointment to the US Army Research Laboratory Postdoctoral Fellowship Program administered by the Oak Ridge Associated Universities through a contract with the US Army Research Laboratory. K.J.S. recognizes support from the Notre Dame Institute for Scholarship in the Liberal Arts. M.L. acknowledges support from DanScatt. We acknowledge the support of the National Institute of Standards and Technology, US Department of Commerce, in providing the neutron research facilities used in this work. The research at Oak Ridge National Laboratory's High Flux Isotope Reactor was sponsored by the Scientific User Facilities Division, Office of Basic Energy Sciences, US Department of Energy. The work at Ames Laboratory was supported by the US Department of Energy, Office of Basic Energy Science, Division of Materials Sciences and Engineering. Ames Laboratory is operated for the US Department of Energy by Iowa State University under Contract No. DE-AC02-07CH11358. NR 29 TC 0 Z9 0 U1 0 U2 14 PU AMER PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 1098-0121 J9 PHYS REV B JI Phys. Rev. B PD OCT 1 PY 2012 VL 86 IS 14 AR 144501 DI 10.1103/PhysRevB.86.144501 PG 7 WC Physics, Condensed Matter SC Physics GA 013ZS UT WOS:000309345400006 ER PT J AU Mitchell, EH Diaz, A Yilmaz, T Roberts, D Levine, N DeMonte, F Hanna, EY Kupferman, ME AF Mitchell, Elisabeth H. Diaz, Alvaro Yilmaz, Turker Roberts, Dianna Levine, Nicholas DeMonte, Franco Hanna, Ehab Y. Kupferman, Michael E. TI Multimodality treatment for sinonasal neuroendocrine carcinoma SO HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK LA English DT Article DE neuroendocrine carcinoma; paranasal sinus; definitive management; systemic therapy; survival rates ID PARANASAL SINUSES; NASAL CAVITY; TUMORS; SURGERY; TRACT AB Background Neuroendocrine carcinoma (NEC) of the paranasal sinuses is rare, accounting for 5% of sinonasal malignancies. The purpose of this study was to assess prognostic factors and survival rates for sinonasal NEC. Methods A retrospective review of patients with NEC treated from 1990 to 2004 was performed. Patient demographics, TNM classification, treatment modality, recurrences, and survival were evaluated. Results NEC was identified in 28 patients; the most common primary site was the ethmoid sinuses. Most patients presented with advanced tumors; few had regional or distant metastasis. Local recurrence rate was 21%. Five-year overall survival (OS) and disease-specific survival (DSS) rates were 65% and 78%, respectively. Response to chemotherapy predicted for improved survival, although no differences in outcomes were noted between definitive management strategies. Conclusion NEC of the paranasal sinuses is an exceedingly rare malignancy of the paranasal sinuses. Our data suggests definitive management with surgery or radiotherapy offers durable control. The response to chemotherapy may predict for overall outcomes. (c) 2011 Wiley Periodicals, Inc. Head Neck, 2011 C1 [Diaz, Alvaro; Yilmaz, Turker; Roberts, Dianna; Hanna, Ehab Y.; Kupferman, Michael E.] Univ Texas MD Anderson Canc Ctr, Dept Head & Neck Surg, Houston, TX 77030 USA. [Mitchell, Elisabeth H.] Walter Reed Army Med Ctr, Dept Otolaryngol Head & Neck Surg, Washington, DC 20307 USA. [Levine, Nicholas; DeMonte, Franco] Univ Texas MD Anderson Canc Ctr, Dept Neurosurg, Houston, TX 77030 USA. RP Kupferman, ME (reprint author), Univ Texas MD Anderson Canc Ctr, Dept Head & Neck Surg, 1515 Holcombe Blvd,Unit 1445, Houston, TX 77030 USA. EM mekupfer@mdanderson.org RI YILMAZ, TANER/I-9657-2013; Hanna, Ehab/B-1593-2017 OI YILMAZ, TANER/0000-0001-8999-3237; Hanna, Ehab/0000-0003-3241-2440 FU NCI NIH HHS [P30 CA016672] NR 15 TC 11 Z9 15 U1 0 U2 1 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1043-3074 J9 HEAD NECK-J SCI SPEC JI Head Neck-J. Sci. Spec. Head Neck PD OCT PY 2012 VL 34 IS 10 BP 1372 EP 1376 DI 10.1002/hed.21940 PG 5 WC Otorhinolaryngology; Surgery SC Otorhinolaryngology; Surgery GA 008PK UT WOS:000308968800003 PM 22052583 ER PT J AU D'Souza, AI Robinson, E Ionescu, AC Okerlund, D de Lyon, TJ Sharifi, H Roebuck, M Yap, D Rajavel, RD Dhar, N Wijewarnasuriya, PS Grein, C AF D'Souza, A. I. Robinson, E. Ionescu, A. C. Okerlund, D. de Lyon, T. J. Sharifi, H. Roebuck, M. Yap, D. Rajavel, R. D. Dhar, N. Wijewarnasuriya, P. S. Grein, C. TI Electrooptical Characterization of MWIR InAsSb Detectors SO JOURNAL OF ELECTRONIC MATERIALS LA English DT Article; Proceedings Paper CT US Workshop on the Physics and Chemistry of II-VI Materials CY OCT 04-06, 2011 CL Chicago, IL DE MWIR barrier detectors; photon-trap structures ID INAS1-XSBX AB InAs1-x Sb (x) material with an alloy composition of the absorber layer adjusted to achieve 200-K cutoff wavelengths in the 5-mu m range has been grown. Compound-barrier (CB) detectors were fabricated and tested for optical response, and J (dark)-V (d) measurements were taken as a function of temperature. Based on absorption coefficient information in the literature and spectral response measurements of the midwave infrared (MWIR) nCBn detectors, an absorption coefficient formula alpha(I center dot, x, T) is proposed. Since the presently suggested absorption coefficient is based on limited data, additional measurements of material and detectors with different x values and as a function of temperature should refine the absorption coefficient, providing more accurate parametrization. Material electronic structures were computed using a k center dot p formalism. From the band structure, dark-current density (J (dark)) as a function of bias (V (d)) and temperature (T) was calculated and matched to J (dark)-V (d) curves at fixed T and J (dark)-T curves at constant V (d). There is a good match between simulation and data over a wide range of bias, but discrepancies that are not presently understood exist near zero bias. C1 [D'Souza, A. I.; Robinson, E.; Ionescu, A. C.; Okerlund, D.] DRS Sensors & Targeting Syst, Cypress, CA 90630 USA. [de Lyon, T. J.; Sharifi, H.; Roebuck, M.; Yap, D.; Rajavel, R. D.] HRL Labs LLC, Malibu, CA 90265 USA. [Dhar, N.] MTO, DARPA, Arlington, VA 22203 USA. [Wijewarnasuriya, P. S.] USA, Res Lab, Adelphi, MD 20783 USA. [Grein, C.] Univ Illinois, Chicago, IL 60607 USA. RP D'Souza, AI (reprint author), DRS Sensors & Targeting Syst, 10600 Valley View St, Cypress, CA 90630 USA. EM arvind.d'souza@drs-sts.com FU DARPA [N66604-09-C-3652] FX This work was supported by DARPA under Contract N66604-09-C-3652 (Dr. Nibir Dhar, DARPA Program Manager). However, the views expressed are those of the author and do not reflect the official policy or position of the Department of Defense or the US Government. This is in accordance with DoDI 5230.29, January 8, 2009. Special thanks go to Mr. Dan Okerlund, the ever-patient Program Manager at DRS, Dr. Ravi Dat, Booz Allen Hamilton for technical and other advice, and Ms. Yesim Anter for helping prepare the manuscript. Excellent work was performed by Prof. Saif Islam and his team at UC Davis, who were instrumental in different aspects of the processing sequence. NR 12 TC 14 Z9 14 U1 0 U2 31 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0361-5235 EI 1543-186X J9 J ELECTRON MATER JI J. Electron. Mater. PD OCT PY 2012 VL 41 IS 10 BP 2671 EP 2678 DI 10.1007/s11664-012-2182-7 PG 8 WC Engineering, Electrical & Electronic; Materials Science, Multidisciplinary; Physics, Applied SC Engineering; Materials Science; Physics GA 004BQ UT WOS:000308655500003 ER PT J AU Jacobs, RN Nozaki, C Almeida, LA Jaime-Vasquez, M Lennon, C Markunas, JK Benson, D Smith, P Zhao, WF Smith, DJ Billman, C Arias, J Pellegrino, J AF Jacobs, R. N. Nozaki, C. Almeida, L. A. Jaime-Vasquez, M. Lennon, C. Markunas, J. K. Benson, D. Smith, P. Zhao, W. F. Smith, D. J. Billman, C. Arias, J. Pellegrino, J. TI Development of MBE II-VI Epilayers on GaAs(211)B SO JOURNAL OF ELECTRONIC MATERIALS LA English DT Article; Proceedings Paper CT US Workshop on the Physics and Chemistry of II-VI Materials CY OCT 04-06, 2011 CL Chicago, IL DE HgCdTe; gallium arsenide; CdTe; IRFPA; II-VI semiconductors; MBE; large-area substrates ID CDTE HETEROEPITAXY; HGCDTE; GROWTH; SI; DISLOCATIONS; CATHODOLUMINESCENCE; MICROSCOPY; MORPHOLOGY; DETECTORS; EPITAXY AB Large-area, low-cost substrates are envisioned for next-generation HgCdTe infrared focal-plane arrays (IRFPA). Si, GaAs, Ge, and InSb have been previously examined as potential candidates. Fabrication of IRFPAs based on these substrates is limited by fundamental materials properties that potentially lead to lower detector performance and operability. Lattice and thermal mismatch between the substrate and epilayer are just two of several material factors that must be considered. We have reviewed these factors in the context of more recent data, and determined it worthwhile to revisit the use of GaAs substrates for epitaxial growth of HgCdTe. Our study starts with an evaluation of the surface quality (epireadiness) of commercially available (211) B-oriented GaAs substrates. Molecular beam epitaxial growth of CdTe buffer layers and subsequent HgCdTe absorber layers are performed in separate vacuum-interconnected chambers. The importance of optimization of the CdTe buffer layer growth for high-quality HgCdTe is detailed through surface morphology and x-ray studies. x-Ray diffraction rocking-curve full-width at half-maximum values as low as 52 arcsec have been obtained. Long-wave infrared Hg1-x Cd (x) Te (x = 0.23) has been grown on these buffer layers, producing cross-hatch-dominated surface morphologies, with dislocation densities as low as similar to 3 x 10(6) cm(-2). We have also obtained (for optimized layers), 80-K Hall-effect n-type carrier concentration and electron mobility of approximately similar to 1.5 x 10(15) cm(-3) and 1 x 10(5) cm(2) V-1 s(-1), respectively. Finally, we briefly compare GaAs and Si in light of our preliminary investigation. C1 [Jacobs, R. N.; Nozaki, C.; Almeida, L. A.; Jaime-Vasquez, M.; Markunas, J. K.; Benson, D.; Smith, P.; Billman, C.; Pellegrino, J.] USA, RDECOM CERDEC Night Vis & Elect Sensors Directora, Ft Belvoir, VA USA. [Zhao, W. F.; Smith, D. J.] Arizona State Univ, Dept Phys, Tempe, AZ 85287 USA. [Lennon, C.] Corbin Co, Alexandria, VA USA. [Arias, J.] RAND Corp, Santa Monica, CA USA. RP Jacobs, RN (reprint author), USA, RDECOM CERDEC Night Vis & Elect Sensors Directora, Ft Belvoir, VA USA. EM rjacobs@nvl.army.mil NR 17 TC 13 Z9 13 U1 3 U2 30 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0361-5235 EI 1543-186X J9 J ELECTRON MATER JI J. Electron. Mater. PD OCT PY 2012 VL 41 IS 10 BP 2707 EP 2713 DI 10.1007/s11664-012-2218-z PG 7 WC Engineering, Electrical & Electronic; Materials Science, Multidisciplinary; Physics, Applied SC Engineering; Materials Science; Physics GA 004BQ UT WOS:000308655500008 ER PT J AU Carmody, M Yulius, A Edwall, D Lee, D Piquette, E Jacobs, R Benson, D Stoltz, A Markunas, J Almeida, A Arias, J AF Carmody, M. Yulius, A. Edwall, D. Lee, D. Piquette, E. Jacobs, R. Benson, D. Stoltz, A. Markunas, J. Almeida, A. Arias, J. TI Recent Progress in MBE Growth of CdTe and HgCdTe on (211)B GaAs Substrates SO JOURNAL OF ELECTRONIC MATERIALS LA English DT Article; Proceedings Paper CT US Workshop on the Physics and Chemistry of II-VI Materials CY OCT 04-06, 2011 CL Chicago, IL DE MBE; HgCdTe; GaAs; alternate substrate ID MOLECULAR-BEAM EPITAXY; WAVELENGTH INFRARED HGCDTE; SI DETECTOR PERFORMANCE; DISLOCATION DENSITIES; LWIR HGCDTE; SILICON; TECHNOLOGY AB Alternate substrates for molecular beam epitaxy growth of HgCdTe including Si, Ge, and GaAs have been under development for more than a decade. MBE growth of HgCdTe on GaAs substrates was pioneered by Teledyne Imaging Sensors (TIS) in the 1980s. However, recent improvements in the layer crystal quality including improvements in both the CdTe buffer layer and the HgCdTe layer growth have resulted in GaAs emerging as a strong candidate for replacement of bulk CdZnTe substrates for certain infrared imaging applications. In this paper the current state of the art in CdTe and HgCdTe MBE growth on (211)B GaAs and (211) Si at TIS is reviewed. Recent improvements in the CdTe buffer layer quality (double crystal rocking curve full-width at half-maximum a parts per thousand 30 arcsec) with HgCdTe dislocation densities of a parts per thousand currency sign10(6) cm(-2) are discussed and comparisons are made with historical HgCdTe on bulk CdZnTe and alternate substrate data at TIS. Material properties including the HgCdTe majority carrier mobility and dislocation density are presented as a function of the CdTe buffer layer quality. C1 [Carmody, M.; Yulius, A.; Edwall, D.; Lee, D.; Piquette, E.] Teledyne Imaging Sensors, Camarillo, CA 93012 USA. [Jacobs, R.; Benson, D.; Stoltz, A.; Markunas, J.; Almeida, A.; Arias, J.] USA, RDECOM CERDEC NVESD, Ft Belvoir, VA 22060 USA. RP Carmody, M (reprint author), Teledyne Imaging Sensors, 5212 Verdugo Way, Camarillo, CA 93012 USA. EM mcarmody@teledyne.com NR 14 TC 8 Z9 8 U1 2 U2 23 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0361-5235 EI 1543-186X J9 J ELECTRON MATER JI J. Electron. Mater. PD OCT PY 2012 VL 41 IS 10 BP 2719 EP 2724 DI 10.1007/s11664-012-2129-z PG 6 WC Engineering, Electrical & Electronic; Materials Science, Multidisciplinary; Physics, Applied SC Engineering; Materials Science; Physics GA 004BQ UT WOS:000308655500010 ER PT J AU Maloney, PG Dewames, R Pellegrino, JG Billman, C Arias, JM Edwall, DD Lee, D Khurgin, J AF Maloney, P. G. Dewames, R. Pellegrino, J. G. Billman, C. Arias, J. M. Edwall, D. D. Lee, D. Khurgin, J. TI Measurement of Minority Carrier Lifetime in n-Type MBE HgCdTe on Variable Substrates SO JOURNAL OF ELECTRONIC MATERIALS LA English DT Article; Proceedings Paper CT US Workshop on the Physics and Chemistry of II-VI Materials CY OCT 04-06, 2011 CL Chicago, IL DE HgCdTe; photoconductivity transient; photoconductive decay; lifetime; current-voltage; infrared ID RECOMBINATION; SEMICONDUCTORS; DIODES; GAAS AB This paper correlates measurements of minority carrier lifetime using photoconductivity transient or photoconductive decay (PCD) with measurements and analysis of current-voltage (I-V) on P (+) n photodiodes of the same layer. This analysis is done at the primary temperature of operation near 77 K. Measurements of minority carrier lifetime in n-type molecular beam epitaxy Hg1-x Cd (x) Te (MCT) on variable substrates of GaAs and CdZnTe are presented. The minority carrier lifetime from I-V analysis of P (+) n long-wave infrared (LWIR) photodiodes on CdZnTe (CZT) and GaAs substrates is similar to PCD analysis. Deviations occur for MCT/GaAs in the low-temperature extrinsic region associated with Shockley-Read-Hall (SRH) at 78 K in contrast to MCT/CZT at similar temperatures. The x-values in the formula Hg1-x Cd (x) Te for samples grown on CdZnTe and GaAs are 0.22 and 0.235, respectively. I-V analysis of variable-area LWIR photodiodes shows a calculated minority carrier diffusion coefficient of 2.3 cm(2)/s on lattice-matched CZT and 3 cm(2)/s on non-lattice-matched GaAs with diffusion lengths of approximately 24 mu m and 20 mu m, respectively. C1 [Maloney, P. G.; Dewames, R.; Pellegrino, J. G.; Billman, C.; Arias, J. M.] USA, RDECOM CERDEC NVESD, Ft Belvoir, VA 22060 USA. [Edwall, D. D.; Lee, D.] Teledyne Sci & Imaging, Thousand Oaks, CA 91360 USA. [Khurgin, J.] Johns Hopkins Univ, Dept Elect & Comp Engn, Baltimore, MD 21218 USA. RP Maloney, PG (reprint author), USA, RDECOM CERDEC NVESD, 10221 Burbeck Rd, Ft Belvoir, VA 22060 USA. EM info@nvl.army.mil RI khurgin, Jacob/A-3278-2010 NR 18 TC 1 Z9 1 U1 0 U2 13 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0361-5235 EI 1543-186X J9 J ELECTRON MATER JI J. Electron. Mater. PD OCT PY 2012 VL 41 IS 10 BP 2785 EP 2789 DI 10.1007/s11664-012-2062-1 PG 5 WC Engineering, Electrical & Electronic; Materials Science, Multidisciplinary; Physics, Applied SC Engineering; Materials Science; Physics GA 004BQ UT WOS:000308655500019 ER PT J AU Shintri, S Rao, S Wijewarnasuriya, P Trivedi, S Bhat, I AF Shintri, Shashidhar Rao, Sunil Wijewarnasuriya, Priyalal Trivedi, Sudhir Bhat, Ishwara TI Recent Results on Growth of (211)B CdTe on (211)Si with Intermediate Ge and ZnTe Buffer Layers by Metalorganic Vapor-Phase Epitaxy SO JOURNAL OF ELECTRONIC MATERIALS LA English DT Article; Proceedings Paper CT US Workshop on the Physics and Chemistry of II-VI Materials CY OCT 04-06, 2011 CL Chicago, IL DE Cadmium telluride; epitaxy; metalorganic vapor-phase epitaxy (MOVPE); (211)Si ID MOLECULAR-BEAM EPITAXY; SILICON; HGCDTE AB We report on the investigation of epitaxial cadmium telluride grown by metalorganic vapor-phase epitaxy (MOVPE) on (211)Si, with particular emphasis on studying the effect of changing the reactor parameters and thermal annealing conditions on the epilayer quality. The CdTe films were characterized by scanning electron microscopy (SEM), atomic force microscopy (AFM), and x-ray diffraction (XRD). The best CdTe films were observed when the Te/Cd precursor partial pressure ratio was close to 3.1. It was also observed that, though annealing improved the crystal quality, a slight increase in surface roughness was observed. Similar attempts were made to improve the growth conditions of ZnTe intermediate buffer layer, which showed similar trends with changes in precursor flows. C1 [Shintri, Shashidhar] Rensselaer Polytech Inst, Dept Engn Sci, Troy, NY 12180 USA. [Rao, Sunil; Bhat, Ishwara] Rensselaer Polytech Inst, Dept Elect Comp & Syst Engn, Troy, NY 12180 USA. [Wijewarnasuriya, Priyalal] USA, Res Lab, Adelphi, MD 20783 USA. [Trivedi, Sudhir] Brimrose Corp Amer, Sparks, MD 21152 USA. RP Shintri, S (reprint author), Rensselaer Polytech Inst, Dept Engn Sci, Troy, NY 12180 USA. EM shints@rpi.edu FU US Army STTR through Brimrose Corporation [W911NF-08-C-0071] FX This work was partially supported by US Army STTR Contract W911NF-08-C-0071 through Brimrose Corporation. We thank Dr. William Clark of ARO for all the encouragement. NR 9 TC 0 Z9 0 U1 0 U2 8 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0361-5235 EI 1543-186X J9 J ELECTRON MATER JI J. Electron. Mater. PD OCT PY 2012 VL 41 IS 10 BP 2824 EP 2827 DI 10.1007/s11664-012-1947-3 PG 4 WC Engineering, Electrical & Electronic; Materials Science, Multidisciplinary; Physics, Applied SC Engineering; Materials Science; Physics GA 004BQ UT WOS:000308655500025 ER PT J AU Zhao, WF Brill, G Chen, Y Smith, DJ AF Zhao, W. F. Brill, G. Chen, Y. Smith, David J. TI Microstructural Characterization of HgCdSe Grown by Molecular Beam Epitaxy on ZnTe/Si(112) and GaSb(112) Substrates SO JOURNAL OF ELECTRONIC MATERIALS LA English DT Article; Proceedings Paper CT US Workshop on the Physics and Chemistry of II-VI Materials CY OCT 04-06, 2011 CL Chicago, IL DE HgCdSe; ZnTe/Si(112); GaSb(112); MBE; TEM AB Transmission electron microscopy and small-probe microanalysis have been used to investigate the microstructure of HgCdSe thin films grown by molecular beam epitaxy on ZnTe/Si(112) and GaSb(112) substrates. The quality of the HgCdSe material was dependent on the growth temperature and materials flux, independent of the substrate. Samples grown at 100A degrees C were generally of high quality, while those grown at 140A degrees C had {111}-type stacking defects and increased dislocation densities. Improved preparation of the GaSb buffer layer should be developed for future HgCdSe growth on GaSb(112) substrates. C1 [Zhao, W. F.] Arizona State Univ, Sch Mat, Tempe, AZ 85287 USA. [Brill, G.; Chen, Y.] USA, Res Lab, Sensors & Elect Devices Directorate, Adelphi, MD 20783 USA. [Smith, David J.] Arizona State Univ, Dept Phys, Tempe, AZ 85287 USA. RP Zhao, WF (reprint author), Arizona State Univ, Sch Mat, Tempe, AZ 85287 USA. EM wenfeng.zhao@asu.edu RI Brill, Gregory/G-4877-2013 FU U.S. Army Research Laboratory; U.S. Army Research Office [54657 EL] FX The work at Arizona State University has been supported by the U.S. Army Research Laboratory and the U.S. Army Research Office under Contract #54657 EL (Monitor: Dr. W.W. Clark). We also acknowledge the use of facilities in the John M. Cowley Center for High Resolution Electron Microscopy. NR 9 TC 3 Z9 5 U1 2 U2 19 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0361-5235 EI 1543-186X J9 J ELECTRON MATER JI J. Electron. Mater. PD OCT PY 2012 VL 41 IS 10 BP 2852 EP 2856 DI 10.1007/s11664-012-2069-7 PG 5 WC Engineering, Electrical & Electronic; Materials Science, Multidisciplinary; Physics, Applied SC Engineering; Materials Science; Physics GA 004BQ UT WOS:000308655500030 ER PT J AU Chen, YP Simingalam, S Brill, G Wijewarnasuriya, P Dhar, N Kim, JJ Smith, DJ AF Chen, Yuanping Simingalam, Sina Brill, Gregory Wijewarnasuriya, Priyalal Dhar, Nibir Kim, Jae Jin Smith, David J. TI MBE-Grown ZnTe/Si, a Low-Cost Composite Substrate SO JOURNAL OF ELECTRONIC MATERIALS LA English DT Article; Proceedings Paper CT US Workshop on the Physics and Chemistry of II-VI Materials CY OCT 04-06, 2011 CL Chicago, IL DE ZnTe; ZnSeTe; MBE; Si; HgCdSe; T2-SLS ID MOLECULAR-BEAM EPITAXY; DETECTORS; DISLOCATIONS; SI(001); CDTE AB Growth of ZnTe on Si using molecular beam epitaxy (MBE) has been pursued as a new approach for a lattice-matched, large-area, low-cost alternate substrate for both II-VI and III-V compound semiconductors with lattice constants very near 6.1 , such as HgCdSe and GaSb-based type II strained-layer superlattices. In this paper, we report our findings on the systematic study of MBE growth parameters for both ZnTe(211) on Si(211) and ZnTe(100) on Si(100). Near-optimal growth procedures have been established for producing ZnTe/Si wafers with high crystallinity, low defect and etch pit densities, as well as excellent surface morphology. Using this baseline MBE growth process, we obtained ZnTe(211)/Si wafers with x-ray full-width at half-maximum as low as 70 arcsec. C1 [Chen, Yuanping; Brill, Gregory; Wijewarnasuriya, Priyalal; Dhar, Nibir] USA, Res Lab, Adelphi, MD 20783 USA. [Simingalam, Sina] George Mason Univ, Fairfax, VA 22030 USA. [Dhar, Nibir] MTO, DARPA, Arlington, VA 22203 USA. [Kim, Jae Jin] Arizona State Univ, Sch Engn Matter Transport & Energy, Tempe, AZ 85287 USA. [Smith, David J.] Arizona State Univ, Dept Phys, Tempe, AZ 85287 USA. RP Chen, YP (reprint author), USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM yuanping.chen.civ@mail.mil RI Brill, Gregory/G-4877-2013 FU Air Force Office of Scientific Research [FIATA00165G001]; U.S. Army Research Office [54657 EL] FX This work was partially supported by Air Force Office of Scientific Research through a Contract (FIATA00165G001) managed by Dr. Kitt Reinhardt. The electron microscopy at Arizona State University has been supported by the U.S. Army Research Laboratory and the U.S. Army Research Office under Contract #54657 EL (Monitor: Dr. W. W. Clark). NR 27 TC 3 Z9 5 U1 3 U2 16 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0361-5235 EI 1543-186X J9 J ELECTRON MATER JI J. Electron. Mater. PD OCT PY 2012 VL 41 IS 10 BP 2917 EP 2924 DI 10.1007/s11664-012-2032-7 PG 8 WC Engineering, Electrical & Electronic; Materials Science, Multidisciplinary; Physics, Applied SC Engineering; Materials Science; Physics GA 004BQ UT WOS:000308655500040 ER PT J AU Stoltz, AJ Benson, JD Jacobs, R Smith, P Almeida, LA Carmody, M Farrell, S Wijewarnasuriya, PS Brill, G Chen, Y AF Stoltz, A. J. Benson, J. D. Jacobs, R. Smith, P. Almeida, L. A. Carmody, M. Farrell, S. Wijewarnasuriya, P. S. Brill, G. Chen, Y. TI Reduction of Dislocation Density by Producing Novel Structures SO JOURNAL OF ELECTRONIC MATERIALS LA English DT Article; Proceedings Paper CT US Workshop on the Physics and Chemistry of II-VI Materials CY OCT 04-06, 2011 CL Chicago, IL DE HgCdTe; defects; EPD; etch pit density; dislocations; gettering; alternate substrate; ICP; plasma processing ID MOLECULAR-BEAM EPITAXY; CROSS-HATCH; HGCDTE; SI AB HgCdTe, because of its narrow band gap and low dark current, is the infrared detector material of choice for several military and commercial applications. CdZnTe is the substrate of choice for HgCdTe as it can be lattice matched, resulting in low-defect-density epitaxy. Being often small and not circular, layers grown on CdZnTe are difficult to process in standard semiconductor equipment. Furthermore, CdZnTe can often be very expensive. Alternate inexpensive large circular substrates, such as silicon or gallium arsenide, are needed to scale HgCdTe detector production. Growth of HgCdTe on these alternate substrates has its own difficulty, namely large lattice mismatch (19% for Si and 14% for GaAs). This large mismatch results in high defect density and reduced detector performance. In this paper we discuss ways to reduce the effects of dislocations by gettering these defects to the edge of a reticulated structure. These reticulated surfaces enable stress-free regions for dislocations to glide to. In this work, a novel structure was developed that allows for etch pit density of less than 4 x 10(5)/cm(2) for HgCdTe-on-Si. This is almost two orders of magnitude less than the as-grown etch pit density of 1.1 x 10(7)/cm(2). This value of 3.35 x 10(5)/cm(2) is below the < 1 x 10(6)/cm(2) or even the better < 5 x 10(5)/cm(2) target for this research, making HgCdTe-on- alternate substrate density much more like that of HgCdTe-on-CdZnTe. C1 [Stoltz, A. J.; Benson, J. D.; Jacobs, R.; Smith, P.; Almeida, L. A.] US Army, RDECOM, CERDEC, NVESD, Ft Belvoir, VA 22060 USA. [Carmody, M.] Teledyne Imaging Sensors, Camarillo, CA 93012 USA. [Farrell, S.; Wijewarnasuriya, P. S.; Brill, G.; Chen, Y.] US Army, Army Res Lab, Adelphi, MD 20783 USA. RP Stoltz, AJ (reprint author), US Army, RDECOM, CERDEC, NVESD, Ft Belvoir, VA 22060 USA. EM andrew.stoltz@us.army.mil RI Brill, Gregory/G-4877-2013 NR 13 TC 4 Z9 4 U1 2 U2 15 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0361-5235 EI 1543-186X J9 J ELECTRON MATER JI J. Electron. Mater. PD OCT PY 2012 VL 41 IS 10 BP 2949 EP 2956 DI 10.1007/s11664-012-2106-6 PG 8 WC Engineering, Electrical & Electronic; Materials Science, Multidisciplinary; Physics, Applied SC Engineering; Materials Science; Physics GA 004BQ UT WOS:000308655500045 ER PT J AU Lennon, CM Almeida, LA Jacobs, RN Markunas, JK Smith, PJ Arias, J Brown, AE Pellegrino, J AF Lennon, C. M. Almeida, L. A. Jacobs, R. N. Markunas, J. K. Smith, P. J. Arias, J. Brown, A. E. Pellegrino, J. TI Real-Time In Situ Monitoring of GaAs (211) Oxide Desorption and CdTe Growth by Spectroscopic Ellipsometry SO JOURNAL OF ELECTRONIC MATERIALS LA English DT Article; Proceedings Paper CT US Workshop on the Physics and Chemistry of II-VI Materials CY OCT 04-06, 2011 CL Chicago, IL DE CdTe; HgCdTe; GaAs; molecular beam epitaxy; infrared; spectroscopic ellipsometry ID MOLECULAR-BEAM EPITAXY; HGCDTE; HG1-XCDXTE; SUBSTRATE; QUALITY AB We describe the growth of CdTe (211)B by molecular beam epitaxy on large-area epiready GaAs (211)B substrates. Prior to CdTe growth, GaAs substrates were thermally cleaned under an As-4 flux. Oxide desorption was verified by in situ spectroscopic ellipsometry (SE) and reflection high-energy electron diffraction. The use of in situ SE played a significant role in the study of CdTe-on-GaAs growth and annealing processes. An effective medium approximation (EMA) was used to model the overlayer thickness variation of CdTe epilayers throughout growth and in situ annealing cycles. A correlation between SE-derived EMA thickness values and surface defect formation mitigation is discussed. All annealed samples (11.5 mu m to 13 mu m thick) exhibited excellent crystalline quality with average double crystal rocking curve full-width at half-maximum (FWHM) values of similar to 60 arcsec. C1 [Lennon, C. M.] Corbin Co, Alexandria, VA 22314 USA. [Lennon, C. M.; Almeida, L. A.; Jacobs, R. N.; Markunas, J. K.; Smith, P. J.; Arias, J.; Pellegrino, J.] USA, RDECOM, CERDEC, Night Vis & Elect Sensors Directorate, Ft Belvoir, VA 22060 USA. [Arias, J.] RAND Corp, Santa Monica, CA 90401 USA. [Brown, A. E.] Univ Illinois, Dept Phys, Microphys Lab, Chicago, IL 60607 USA. RP Lennon, CM (reprint author), Corbin Co, Alexandria, VA 22314 USA. EM info@us.army.mil NR 23 TC 4 Z9 4 U1 1 U2 8 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0361-5235 EI 1543-186X J9 J ELECTRON MATER JI J. Electron. Mater. PD OCT PY 2012 VL 41 IS 10 BP 2965 EP 2970 DI 10.1007/s11664-012-2088-4 PG 6 WC Engineering, Electrical & Electronic; Materials Science, Multidisciplinary; Physics, Applied SC Engineering; Materials Science; Physics GA 004BQ UT WOS:000308655500047 ER PT J AU Benson, JD Bubulac, LO Smith, PJ Jacobs, RN Markunas, JK Jaime-Vasquez, M Almeida, LA Stoltz, A Arias, JM Brill, G Chen, Y Wijewarnasuriya, PS Farrell, S Lee, U AF Benson, J. D. Bubulac, L. O. Smith, P. J. Jacobs, R. N. Markunas, J. K. Jaime-Vasquez, M. Almeida, L. A. Stoltz, A. Arias, J. M. Brill, G. Chen, Y. Wijewarnasuriya, P. S. Farrell, S. Lee, U. TI Growth and Analysis of HgCdTe on Alternate Substrates SO JOURNAL OF ELECTRONIC MATERIALS LA English DT Article; Proceedings Paper CT US Workshop on the Physics and Chemistry of II-VI Materials CY OCT 04-06, 2011 CL Chicago, IL DE HgCdTe/CdTe/alternate substrate; molecular beam epitaxy; dislocation; Hg thermal annealing; etch pit density; x-ray diffraction ID MOLECULAR-BEAM EPITAXY; (112)B HGCDTE/CDTE/SI; SI; PERFORMANCE AB Dislocations generated at the HgCdTe/CdTe(buffer layer) interface are demonstrated to play a significant role in influencing the crystalline characteristics of HgCdTe epilayers on alternate substrates (AS). A dislocation density > 10(8) cm(-2) is observed at the HgCdTe/CdTe interface. Networks of dislocations are generated at the HgCdTe/CdTe interface. The dislocation networks are observed to entangle. Significant dislocation reduction occurs within a few microns of the HgCdTe/CdTe interface. The reduction in dislocation density as a function of depth is enhanced by annealing. Etch pit density and x-ray diffraction full-width at half-maximum values increase as a function of the lattice mismatch between HgCdTe epilayer and the buffer layer/substrate. The experimental results suggest that only by reducing HgCdTe/CdTe lattice mismatch will the desired crystallinity be achieved for HgCdTe epilayers on AS. C1 [Benson, J. D.; Bubulac, L. O.; Smith, P. J.; Jacobs, R. N.; Markunas, J. K.; Jaime-Vasquez, M.; Almeida, L. A.; Stoltz, A.; Arias, J. M.] USA, RDECOM, CERDEC Night Vis & Elect Sensors Directorate, Ft Belvoir, VA USA. [Brill, G.; Chen, Y.; Wijewarnasuriya, P. S.; Farrell, S.; Lee, U.] USA, Res Lab, Adelphi, MD USA. RP Benson, JD (reprint author), USA, RDECOM, CERDEC Night Vis & Elect Sensors Directorate, Ft Belvoir, VA USA. EM david.j.benson@us.army.mil RI Brill, Gregory/G-4877-2013 NR 16 TC 14 Z9 14 U1 0 U2 10 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0361-5235 EI 1543-186X J9 J ELECTRON MATER JI J. Electron. Mater. PD OCT PY 2012 VL 41 IS 10 BP 2971 EP 2974 DI 10.1007/s11664-012-2089-3 PG 4 WC Engineering, Electrical & Electronic; Materials Science, Multidisciplinary; Physics, Applied SC Engineering; Materials Science; Physics GA 004BQ UT WOS:000308655500048 ER PT J AU Jaime-Vasquez, M Jacobs, RN Nozaki, C Benson, JD Almeida, LA Arias, J Pellegrino, J AF Jaime-Vasquez, M. Jacobs, R. N. Nozaki, C. Benson, J. D. Almeida, L. A. Arias, J. Pellegrino, J. TI Understanding the Evolution of CdTe Buffer Layer Surfaces on ZnTe/Si(211) and GaAs(211)B During Cyclic Annealing SO JOURNAL OF ELECTRONIC MATERIALS LA English DT Article; Proceedings Paper CT US Workshop on the Physics and Chemistry of II-VI Materials CY OCT 04-06, 2011 CL Chicago, IL DE CdTe/ZnTe/Si; CdTe/GaAs; molecular beam epitaxy; thermal cyclic annealing; alternative substrates; CdTe buffer layer ID MOLECULAR-BEAM EPITAXY; HETEROEPITAXY; HGCDTE; SI; REDUCTION AB We present the results of a detailed study of the changes that occur on CdTe buffer layer surfaces grown on ZnTe/Si(211) and GaAs(211)B during the routine thermal cyclic annealing (TCA) process. Observations indicate that CdTe buffer layer surfaces are Te saturated when the TCA is performed under Te overpressure. In the absence of Te flux during the TCA step, the CdTe surface loses CdTe congruently and the typical CdTe nanowires show the presence of nodules on their surfaces. The observed changes in reflection high-energy electron diffraction patterns during TCA are explained in terms of surface chemistry and topography observations. Overall, the Te overpressure is necessary to maintain a smoother and pristine surface to continue the molecular beam epitaxy (MBE) growth. C1 [Jaime-Vasquez, M.; Jacobs, R. N.; Nozaki, C.; Benson, J. D.; Almeida, L. A.; Arias, J.; Pellegrino, J.] USA, RDECOM, CERDEC Night Vis & Elect Sensors Directorate, Ft Belvoir, VA 22060 USA. [Arias, J.] RAND Corp, Santa Monica, CA USA. RP Jaime-Vasquez, M (reprint author), USA, RDECOM, CERDEC Night Vis & Elect Sensors Directorate, Ft Belvoir, VA 22060 USA. EM info@us.army.mil NR 16 TC 3 Z9 3 U1 1 U2 5 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0361-5235 EI 1543-186X J9 J ELECTRON MATER JI J. Electron. Mater. PD OCT PY 2012 VL 41 IS 10 BP 2975 EP 2980 DI 10.1007/s11664-012-2169-4 PG 6 WC Engineering, Electrical & Electronic; Materials Science, Multidisciplinary; Physics, Applied SC Engineering; Materials Science; Physics GA 004BQ UT WOS:000308655500049 ER PT J AU Remick, KN Dickerson, JA Cronk, D Topolski, R Nessen, SC AF Remick, Kyle N. Dickerson, James A., II Cronk, Daniel Topolski, Richard Nessen, Shawn C. TI Defining and predicting surgeon utilization at forward surgical teams in Afghanistan SO JOURNAL OF SURGICAL RESEARCH LA English DT Article DE Forward surgical team (FST); Life- or limb-saving surgery (LLSS); Life-saving intervention (LSI); Surgeon utilization; Lactate; Afghanistan ID OPERATION-IRAQI-FREEDOM; TRAUMA SYSTEM-DEVELOPMENT; ENDURING-FREEDOM; COMBAT CASUALTIES; UNITED-STATES; MARINE-CORPS; EXPERIENCE; MORTALITY; BATTLEFIELD; OUTCOMES AB Background: The forward surgical team (FST) is the US Army's smallest surgical element. These teams have supported current conflicts since 2001. The purpose of this study was to determine if surgeon utilization varied at two different FSTs and to determine factors that may predict the need for a surgeon. Method: Data from two FSTs were reviewed. A t-test was used to compare the military injury severity scores (mISS) and the revised trauma scores (RTS). chi(2) analysis was used to compare types and mechanisms of injury and to compare life-or limb-saving surgeries (LLSS) and life-saving interventions among the FSTs. Logistic regression was used to determine if mISS, RTS, physiologic parameters, or laboratory values predicted the need for LLSS or life-saving intervention. Results: The 541st FST treated a larger volume of patients than the 772nd FST (n = 761 versus n = 311). The 772nd FST performed a significantly higher percentage of LLSS; however, absolute number of LLSS was 31 at both FSTs. The mISS among operative patients were similar, but RTS were significantly different (772nd FST = 7.28 versus 541st FST = 7.58, P = 0.008). The 772nd FST saw a higher percentage of motor vehicle collision and rocket-propelled grenade injuries and thoracic and neurologic injuries, and the 541st FST saw a higher percentage of blast and gunshot wound injuries and abdominal injuries. Lactate level was the most significant predictor of the need for LLSS. Conclusion: Although percentage of surgical interventions varied between the two FSTs, the absolute number of needed surgical interventions was the same and was small. Lactate level predicted the need for surgical intervention in our population. Published by Elsevier Inc. C1 [Remick, Kyle N.] Hosp Univ Penn, Div Trauma Surg Crit Care & Emergency Surg, Philadelphia, PA 19104 USA. [Dickerson, James A., II] Brooke Army Med Ctr, Gen Surg Serv, San Antonio, TX USA. [Cronk, Daniel] Blanchfield Army Community Hosp, Gen Surg Serv, Ft Campbell, KY USA. [Topolski, Richard] Augusta State Univ, Eisenhower Army Med Ctr, Dept Psychol, Augusta, GA USA. RP Remick, KN (reprint author), Hosp Univ Penn, Div Trauma Surg Crit Care & Emergency Surg, 3440 Spruce St,5 Maloney, Philadelphia, PA 19104 USA. EM kyle.remick@us.army.mil NR 27 TC 2 Z9 3 U1 0 U2 3 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0022-4804 J9 J SURG RES JI J. Surg. Res. PD OCT PY 2012 VL 177 IS 2 BP 282 EP 287 DI 10.1016/j.jss.2012.07.022 PG 6 WC Surgery SC Surgery GA 004VD UT WOS:000308708400023 PM 22884448 ER PT J AU Morrison, JJ Percival, TJ Markov, NP Villamaria, C Scott, DJ Saches, KA Spencer, JR Rasmussen, TE AF Morrison, Jonathan J. Percival, Thomas J. Markov, Nickolay P. Villamaria, Carole Scott, Daniel J. Saches, Kaylyn A. Spencer, Jerry R. Rasmussen, Todd E. TI Aortic balloon occlusion is effective in controlling pelvic hemorrhage SO JOURNAL OF SURGICAL RESEARCH LA English DT Article DE Hemorrhagic shock; Vascular injury; Pelvic bleeding; Endovascular balloon ID PORCINE MODEL; SHOCK; DRESSINGS; ADJUNCT; TRAUMA; SWINE AB Background: The objective of this study was to evaluate the efficacy of resuscitative endovascular aortic balloon occlusion (REBOA) of the distal aorta in a porcine model of pelvic hemorrhage. Methods: Swine were entered into three phases of study: injury (iliac artery), hemorrhage (45 s), and intervention (180 min). Three groups were studied: no intervention (NI, n = 7), a kaolin-impregnated gauze (Combat Gauze) (CG, n = 7), or REBOA (n = 7). The protocol was repeated with a dilutional coagulopathy (CG-C, n = 7, and REBOA-C, n = 7). Measures of physiology, rates of hemorrhage, and mortality were recorded. Results: Rate of hemorrhage was greatest in the NI group, followed by the REBOA and CG groups (822 +/- 415 mL/min versus 11 +/- 13 and 0.2 +/- 0.4 mL/min respectively; P < 0.001). MAP following intervention (at 15 min) was the same in the CG and REBOA groups and higher than in the NI group (70 +/- 4 and 70 +/- 11 mm Hg versus 5 +/- 13 mm Hg respectively; P < 0.001). There was 100% mortality in the NI group, with no deaths in the CG or REBOA group. In the setting of coagulopathy, the rate of bleeding was higher in the CG-C versus the REBOA-C group (229 +/- 295 mL/min versus 20 +/- 7 mL/min, P = 0.085). MAP following intervention (15 min) was higher in the REBOA-C than the CG-C group (71 +/- 12 mm Hg versus 28 +/- 31 mm Hg; P = 0.005). There were 5 deaths (71.4%) in the CG-C group, but none in the REBOA-C group (P = 0.010). Conclusion: Balloon occlusion of the aorta is an effective method to control pelvic arterial hemorrhage. This technique should be further developed as an adjunct to manage noncompressible pelvic hemorrhage. Published by Elsevier Inc. C1 [Morrison, Jonathan J.; Percival, Thomas J.; Markov, Nickolay P.; Villamaria, Carole; Scott, Daniel J.; Rasmussen, Todd E.] USA, Inst Surg Res, San Antonio, TX 78234 USA. [Morrison, Jonathan J.; Percival, Thomas J.; Markov, Nickolay P.; Villamaria, Carole; Scott, Daniel J.; Saches, Kaylyn A.; Spencer, Jerry R.; Rasmussen, Todd E.] Lackland AFB, Clin Res Div 59, San Antonio, TX USA. [Morrison, Jonathan J.] Royal Ctr Def Med, Acad Dept Mil Surg & Trauma, Birmingham, W Midlands, England. [Rasmussen, Todd E.] Uniformed Serv Univ Hlth Sci, Norman M Rich Dept Surg, Bethesda, MD 20814 USA. RP Rasmussen, TE (reprint author), USA, Inst Surg Res, 3698 Chambers Pass, San Antonio, TX 78234 USA. EM todd.rasmussen@amedd.army.mil OI Morrison, Jonathan/0000-0001-7462-8456 NR 21 TC 41 Z9 41 U1 1 U2 9 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0022-4804 J9 J SURG RES JI J. Surg. Res. PD OCT PY 2012 VL 177 IS 2 BP 341 EP 347 DI 10.1016/j.jss.2012.04.035 PG 7 WC Surgery SC Surgery GA 004VD UT WOS:000308708400034 PM 22591921 ER PT J AU Nagendra, DC Burke, J Maxwell, GL Risinger, JI AF Nagendra, Deepak C. Burke, James, III Maxwell, G. Larry Risinger, John I. TI PPP2R1A mutations are common in the serous type of endometrial cancer SO MOLECULAR CARCINOGENESIS LA English DT Article DE endometrial cancer; PPP2R1A; uterine serous carcinoma; carcinosarcoma ID GENE-EXPRESSION PROFILES; PROTEIN PHOSPHATASE 2A; DIFFERENT HISTOLOGIC TYPES; FOLATE BINDING-PROTEIN; TUMOR-SUPPRESSOR; MICROARRAY ANALYSIS; FGFR2 MUTATIONS; CARCINOMA; OVEREXPRESSION; P53 AB Recently unbiased sequencing efforts identified PPP2R1A mutations in clear cell ovarian cancers (OCC). Similar mutations were also noted with high frequency in uterine serous carcinoma. Because the endometrium develops from the same developmental precursors we further examined the hypothesis that PPP2R1A mutations might also occur in diverse histologic subtypes of uterine cancer. We sequenced the PPP2R1A in 22 cell line models of uterine cancer and 10 primary cancers. We found no mutations in the cell lines originally derived from endometrioid (n?=?13), undifferentiated (n?=?3), clear cell (n?=?1), and carcinosarcoma (n?=?3) cancers. However, we found a CCC (Pro) to CGC (Arg) codon 179 mutation in the ACI-158 serous carcinoma cell line, a CCC (Pro) to CTC (Leu) in a primary serous carcinoma as well as a CGC (Arg) to CAC (His) codon 258 mutation in a poorly differentiated endometrioid cancer. We sequenced a large panel of endometrial malignancies (n?=?181) and found 12 mutants. Importantly, we confirmed a high frequency of mutation in 8 of 25 (32%) serous carcinomas a subtype with well-recognized poor prognosis. Mutations were infrequent in endometrioid cancer and absent in clear cell and carcinosarcoma subtypes. The PPP2R1A mutation regions are conserved among species and known to interact with the regulatory subunits of the PP2A enzyme. PPP2R1A mutant endometrial cancers may represent good candidates for personalized drug therapies particularly for women with the lethal serous histologic variant of uterine cancer. (c) 2011 Wiley Periodicals, Inc. C1 [Risinger, John I.] Michigan State Univ, Coll Human Med, Dept Obstet Gynecol & Reprod Biol, Van Andel Inst, Grand Rapids, MI 49503 USA. [Burke, James, III] Mem Hlth Univ Med Ctr, Curtis & Elizabeth Anderson Canc Inst, Savannah, GA 31404 USA. [Maxwell, G. Larry] Walter Reed Army Med Ctr, Div Gynecol Oncol, Washington, DC 20307 USA. RP Risinger, JI (reprint author), Michigan State Univ, Coll Human Med, Dept Obstet Gynecol & Reprod Biol, Van Andel Inst, 333 Bostwick Ave,Room 4019, Grand Rapids, MI 49503 USA. NR 44 TC 10 Z9 10 U1 0 U2 2 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0899-1987 J9 MOL CARCINOGEN JI Mol. Carcinog. PD OCT PY 2012 VL 51 IS 10 BP 826 EP 831 DI 10.1002/mc.20850 PG 6 WC Biochemistry & Molecular Biology; Oncology SC Biochemistry & Molecular Biology; Oncology GA 003VR UT WOS:000308640000007 PM 21882256 ER PT J AU Mitchell, MM Gallaway, MS Millikan, AM Bell, M AF Mitchell, Mary M. Gallaway, Michael Shayne Millikan, Amy M. Bell, Michael TI Interaction of Combat Exposure and Unit Cohesion in Predicting Suicide-Related Ideation Among Post-Deployment Soldiers SO SUICIDE AND LIFE-THREATENING BEHAVIOR LA English DT Article ID MENTAL-HEALTH PROBLEMS; SOCIAL SUPPORT; MILITARY PERSONNEL; RISK-FACTORS; PREVALENCE; IRAQ; OPERATIONS; COMPONENT; SYMPTOMS; DUTY AB Suicide is one of the leading causes of death among U.S. Army soldiers. Suicide-related ideation, which is associated with suicide attempts and suicide, can cause considerable distress. In a sample of 1,663 recently redeployed soldiers, we used factor analysis and structural equation modeling to test the associations between combat exposure, unit cohesion, and their interaction in predicting suicide-related ideation. We found that combat exposure was a significant risk factor for suicide-related ideation, while unit cohesion was a significant protective factor. The significant interaction between the two factors indicated that soldiers who experienced greater combat exposure but also had higher levels of unit cohesion had relatively lower levels of suicide-related ideation. In addition, those who had higher levels of combat exposure and lower unit cohesion were most at risk for suicide-related ideation. Our findings indicate the importance of unit cohesion in protecting soldiers from suicide-related ideation and suggest a higher risk group of soldiers who should be targeted for interventions. C1 [Mitchell, Mary M.; Gallaway, Michael Shayne; Millikan, Amy M.] USA, Social Hlth Outcomes Program Epidemiol & Dis Surv, Inst Publ Hlth, Edgewood Arsenal Aberdee, MD 21010 USA. [Bell, Michael] Uniformed Serv Univ Hlth Sci, Occupat & Environm Med Residency Program, Bethesda, MD 20814 USA. RP Mitchell, MM (reprint author), USA, Social Hlth Outcomes Program Epidemiol & Dis Surv, Inst Publ Hlth, Edgewood Arsenal Aberdee, MD 21010 USA. EM mary.mo-ser.mitchell@us.army.mil NR 39 TC 8 Z9 8 U1 1 U2 8 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0363-0234 J9 SUICIDE LIFE-THREAT JI Suicide Life-Threat. Behav. PD OCT PY 2012 VL 42 IS 5 BP 486 EP 494 DI 10.1111/j.1943-278X.2012.00106.x PG 9 WC Psychiatry; Psychology, Multidisciplinary SC Psychiatry; Psychology GA 007ZQ UT WOS:000308927300002 PM 22934836 ER PT J AU Colotelo, AH Pflugrath, BD Brown, RS Brauner, CJ Mueller, RP Carlson, TJ Deng, ZD Ahmann, ML Trumbo, BA AF Colotelo, Alison H. Pflugrath, Brett D. Brown, Richard S. Brauner, Colin J. Mueller, Robert P. Carlson, Thomas J. Deng, Z. Daniel Ahmann, Martin L. Trumbo, Bradly A. TI The effect of rapid and sustained decompression on barotrauma in juvenile brook lamprey and Pacific lamprey: Implications for passage at hydroelectric facilities SO FISHERIES RESEARCH LA English DT Article DE Barotrauma; Juvenile salmonids; Juvenile lamprey; Hydropower; Turbine passage ID HYDRO-TURBINE PASSAGE; CHINOOK SALMON; FISH AB Fish passing downstream through hydroelectric facilities may pass through turbines where they experience a rapid decrease in pressure, which can lead to barotraumas including swim bladder rupture, exopthalmia, emboli, and hemorrhaging. In juvenile Chinook salmon, the main mechanism for injury is thought to be expansion of existing gases (particularly those present in the swim bladder) and the rupture of the swim bladder ultimately leading to exopthalmia, emboli and hemorrhaging. In fish lacking a swim bladder, such as lamprey, barotraumas due to rapid decompression may be reduced, however this has yet to be extensively studied. Another mechanism for barotrauma can be gases coming out of solution and the rate of this occurrence may vary among species. In this study, juvenile brook and Pacific lamprey acclimated to 146.2 kPa (equivalent to a depth of 4.6 m) were subjected to rapid (<1 s) or sustained decompression (17 min) to a very low pressure (13.8 kPa) using a protocol previously applied to juvenile salmon. No mortality or evidence of barotraumas was observed following rapid decompression, nor up to 120 h after sustained decompression. In contrast, mortality or injury would be expected for 97.5% of juvenile Chinook salmon exposed to a similar rapid decompression to these very low pressures. Additionally, juvenile Chinook salmon experiencing sustained decompression died within 7 min. Thus, juvenile lamprey may not be susceptible to barotraumas associated with turbine passage to the same degree as juvenile salmonids. Published by Elsevier B.V. C1 [Colotelo, Alison H.; Pflugrath, Brett D.; Brown, Richard S.; Mueller, Robert P.; Carlson, Thomas J.; Deng, Z. Daniel] Pacific NW Natl Lab, Richland, WA 99352 USA. [Brauner, Colin J.] Univ British Columbia, Dept Zool, Vancouver, BC V6T 1Z4, Canada. [Ahmann, Martin L.; Trumbo, Bradly A.] US Army Corps Engineers, Walla Walla, WA 99362 USA. RP Colotelo, AH (reprint author), Pacific NW Natl Lab, Richland, WA 99352 USA. EM Alison.Colotelo@pnl.gov RI Deng, Daniel/A-9536-2011 OI Deng, Daniel/0000-0002-8300-8766 FU U.S. Army Corps of Engineers (USACE); Battelle for the U.S. DOE [DE-AC05-76RL01830] FX Funding was provided by the U.S. Army Corps of Engineers (USACE). The authors thank USACE staff including Robert L. Johnson, Dennis E. Schwartz, Mike J. Langeslay, M. Brad Eppard, Derek Fryer and the USACE Turbine Survival Program. We thank Jill M. Janak, Andrea P. LeBarge, Tim J. Linley, John R. Stephenson, Gayle Dirkes, David Geist, Andrea Currie and Ricardo Walker of PNNL and Greg Kovalchuk and Rick Martinson of Pacific States Marine Fisheries Commission. PNNL animal facilities are AALAC certified; fish were handled in accordance with federal guidelines for the care and use of laboratory animals, and study protocols were approved by the PNNL IACUC. PNNL is operated by Battelle for the U.S. DOE (contract DE-AC05-76RL01830). NR 12 TC 5 Z9 5 U1 3 U2 33 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0165-7836 J9 FISH RES JI Fish Res. PD OCT PY 2012 VL 129 BP 17 EP 20 DI 10.1016/j.fishres.2012.06.001 PG 4 WC Fisheries SC Fisheries GA 996BA UT WOS:000308057800003 ER PT J AU Johnson, MD Schlett, CD Grandits, GA Mende, K Whitman, TJ Tribble, DR Hospenthal, DR Murray, PR AF Johnson, Mark D. Schlett, Carey D. Grandits, Greg A. Mende, Katrin Whitman, Timothy J. Tribble, David R. Hospenthal, Duane R. Murray, Patrick R. TI Chlorhexidine Does Not Select for Resistance in Staphylococcus aureus Isolates in a Community Setting SO INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY LA English DT Letter ID DOUBLE-BLIND; INFECTION; MUPIROCIN; TRIAL C1 [Whitman, Timothy J.] Walter Reed Natl Mil Med Ctr, Dept Infect Dis, Div Infect Dis, Bethesda, MD 20889 USA. [Johnson, Mark D.] USN, Med Ctr, Div Infect Dis, San Diego, CA 92152 USA. [Schlett, Carey D.; Mende, Katrin; Tribble, David R.] Uniformed Serv Univ Hlth Sci, Infect Dis Clin Res Program, Bethesda, MD 20814 USA. [Grandits, Greg A.] Univ Minnesota, Div Biostat, Minneapolis, MN USA. [Mende, Katrin; Hospenthal, Duane R.] Brooke Army Med Ctr, Infect Dis Serv, Ft Sam Houston, TX 78234 USA. [Murray, Patrick R.] NIH, Bethesda, MD 20892 USA. RP Whitman, TJ (reprint author), Walter Reed Natl Mil Med Ctr, Dept Infect Dis, Div Infect Dis, 8901 Wisconsin Ave, Bethesda, MD 20889 USA. EM timothy.whitman@med.navy.mil FU NIAID NIH HHS [Y1-AI-5072] NR 10 TC 3 Z9 3 U1 0 U2 4 PU UNIV CHICAGO PRESS PI CHICAGO PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA SN 0899-823X J9 INFECT CONT HOSP EP JI Infect. Control Hosp. Epidemiol. PD OCT PY 2012 VL 33 IS 10 BP 1061 EP 1063 DI 10.1086/667744 PG 3 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA 004RR UT WOS:000308699300019 PM 22961032 ER PT J AU Kim, SY Hennigan, DJ Kim, D AF Kim, Sang-Young Hennigan, Daniel J. Kim, Dave (Dae-Wook) TI Influence of Fabrication and Interference-Fit Techniques on Tensile and Fatigue Properties of Pin-Loaded Glass Fiber Reinforced Plastics Composites SO JOURNAL OF ENGINEERING MATERIALS AND TECHNOLOGY-TRANSACTIONS OF THE ASME LA English DT Article DE composite; vacuum infusion; hand lay-up; glass fiber; fatigue; pin-loaded holes; interference fit; bearing strength ID BEARING STRENGTH; FAILURE ANALYSIS; JOINTS; CLEARANCE; LAMINATE; BEHAVIOR AB This paper aims to investigate the effect of fabrication processes on fatigue life enhancement of interference-fit pin-loaded glass fiber reinforced plastics (GFRP) composites. In this experimental study, three GFRP composite fabrication processes are used: hand lay-up (HL), vacuum infusion (VI), and hybrid (hand lay-up + vacuum infusion) processes. Stainless steel pins with interference fits ranging from 0% to 1% are inserted into the GFRP samples. The quasi-static and fatigue properties of the pin-loaded composites with interference fit (0.6% and 1%) are then compared to samples with transition-fit (0% of interference fit). Even with possible local damage on the joints, interference fit does not degrade the performance of the composite joints under quasi-static loading, especially when kept under 1% of interference fit. However, fatigue life is highly related to the fabrication processes. Vacuum infusion processed GFRP samples show most visible fatigue life improvement due to interference fit, while hand lay-up or hybrid samples have moderate improvement. Fractography and failure mode of each sample are examined using microscopes. C1 [Kim, Sang-Young; Kim, Dave (Dae-Wook)] Washington State Univ, Sch Engn & Comp Sci, Vancouver, WA 98686 USA. [Hennigan, Daniel J.] USA, Ft Rucker, AL 36362 USA. RP Kim, D (reprint author), Washington State Univ, Sch Engn & Comp Sci, 14204 NE Salmon Creek Ave, Vancouver, WA 98686 USA. EM kimd@wsu.edu RI Kim, Dave(Dae-Wook)/B-3517-2014 FU Christensen Shipyards Ltd.; US Army Research Lab [W911NF-11-1-0023] FX The authors thank for Christensen Shipyards Ltd., and the US Army Research Lab (Grant No. W911NF-11-1-0023) for their generous support for this research. NR 27 TC 1 Z9 3 U1 0 U2 14 PU ASME PI NEW YORK PA TWO PARK AVE, NEW YORK, NY 10016-5990 USA SN 0094-4289 J9 J ENG MATER-T ASME JI J. Eng. Mater. Technol.-Trans. ASME PD OCT PY 2012 VL 134 IS 4 AR 041012 DI 10.1115/1.4007351 PG 8 WC Engineering, Mechanical; Materials Science, Multidisciplinary SC Engineering; Materials Science GA 005AN UT WOS:000308722800012 ER PT J AU Nassar, SA Mao, JH Yang, XJ Templeton, D AF Nassar, Sayed A. Mao, Jianghui Yang, Xianjie Templeton, Douglas TI A Damage Model for Adhesively Bonded Single-Lap Thick Composite Joints SO JOURNAL OF ENGINEERING MATERIALS AND TECHNOLOGY-TRANSACTIONS OF THE ASME LA English DT Article DE laminated composite; adhesive bonding; damage modeling ID DELAMINATION DETECTION; LAMINATED COMPOSITES; STRESSES AB A proposed damage model is used for investigating the deformation and interfacial failure behavior of an adhesively bonded single-lap thick joint made of S2 glass/SC-15 epoxy resin composite material. The bonding material is 3M Scotch-Weld Epoxy Adhesive DP405 Black. Continuum damage mechanics models are used to describe the damage initiation and final failure at or near the interface. The effect of adhesive overlap length, thickness, and plasticity on the interfacial shear and normal stresses is studied. Experimental and analytical data are used to validate the proposed damage models. C1 [Nassar, Sayed A.; Mao, Jianghui; Yang, Xianjie] Oakland Univ, Dept Mech Engn, Fastening & Joining Res Inst, Rochester, MI 48309 USA. [Templeton, Douglas] USA, TARDEC, Warren, MI 48397 USA. RP Nassar, SA (reprint author), Oakland Univ, Dept Mech Engn, Fastening & Joining Res Inst, Rochester, MI 48309 USA. RI Mao, Jianghui/F-8650-2014 OI Mao, Jianghui/0000-0002-2461-482X NR 31 TC 3 Z9 3 U1 4 U2 19 PU ASME PI NEW YORK PA TWO PARK AVE, NEW YORK, NY 10016-5990 USA SN 0094-4289 J9 J ENG MATER-T ASME JI J. Eng. Mater. Technol.-Trans. ASME PD OCT PY 2012 VL 134 IS 4 AR 041004 DI 10.1115/1.4006821 PG 7 WC Engineering, Mechanical; Materials Science, Multidisciplinary SC Engineering; Materials Science GA 005AN UT WOS:000308722800004 ER PT J AU Escamilla, M Lavoy, M Moore, BA Krakow, B AF Escamilla, Monica LaVoy, Mercedes Moore, Bret A. Krakow, Barry TI Management of Post-Traumatic Nightmares: A Review of Pharmacologic and Nonpharmacologic Treatments Since 2010 SO CURRENT PSYCHIATRY REPORTS LA English DT Review DE Sleep disorders; Post-traumatic nightmares; Trauma; Post-traumatic stress disorder; PTSD; Pharmacologic treatments; Behavioral treatments; Sleep treatments; Psychiatry ID STRESS-DISORDER; SLEEP DISTURBANCE; IMAGERY REHEARSAL; TRAUMA NIGHTMARES; COMBAT VETERANS; PTSD; PRAZOSIN; THERAPY; SYMPTOMS; INSOMNIA AB Nightmares are a universal and timeless phenomenon. They occur in most healthy adults as well as a significant portion of clinical populations, especially those exposed to trauma. Considerable advances in the pharmacological and psychological treatment of post-traumatic nightmares have occurred over the last decade with continuing advances in psychological interventions over the last few years. Pharmacologically, the medication prazosin is showing robust clinical effects with minimal side effects. Psychologically, imagery rehearsal therapy commands the greater portion of the nightmare literature due to its established efficacy. These issues are reviewed in the following paper along with recommendations for future studies. C1 [Moore, Bret A.] Warrior Resiliency Program, Behav Readiness Div, San Antonio, TX 78230 USA. [Escamilla, Monica; LaVoy, Mercedes; Moore, Bret A.] USA, Warrior Resiliency Program, San Antonio Mil Med Ctr, So Reg Med Command, San Antonio, TX 78230 USA. [Krakow, Barry] Maimonides Sleep Arts & Sci Ltd, Sleep & Human Hlth Inst, Albuquerque, NM 87109 USA. RP Moore, BA (reprint author), Warrior Resiliency Program, Behav Readiness Div, 7800 IH-10 W Suite 300, San Antonio, TX 78230 USA. EM Monica.Escamilla@amedd.army.mil; Mercedes.LaVoy@amedd.army.mil; bret.moore@us.army.mil; bkrakow@sleeptreatment.com FU CMI/PESI; Wiley; Guilford; APA; Routledge Pearson; Simon Foundation; Oxynard Foundation; Maimonides Sleep Arts and Sciences; New Sleepy Times FX M. Escamilla: none; M. LaVoy: none; B. A. Moore: has been a consultant to Neuroscience Education Institute, has received payment for lectures including service on speakers bureaus from CMI/PESI, and has received royalties from Wiley, Guilford, APA, Routledge & Pearson; B. Krakow: has been a consultant to AMEDD Center & School; has received grants from Simon Foundation and Oxynard Foundation; has received royalties from Wiley, Maimonides Sleep Arts and Sciences, and The New Sleepy Times; and owns and operates 4 websites that provide education and offer products for sleep disorders patients. NR 56 TC 8 Z9 8 U1 3 U2 29 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1523-3812 J9 CURR PSYCHIAT REP JI Curr. Psychiatry Rep. PD OCT PY 2012 VL 14 IS 5 BP 529 EP 535 DI 10.1007/s11920-012-0306-7 PG 7 WC Psychiatry SC Psychiatry GA 999XK UT WOS:000308348800012 PM 22865154 ER PT J AU Balazik, MT McIninch, SP Garman, GC Fine, ML Smith, CB AF Balazik, Matthew T. McIninch, Stephen P. Garman, Greg C. Fine, Michael L. Smith, Clint B. TI Using energy dispersive x-ray fluorescence microchemistry to infer migratory life history of Atlantic sturgeon SO ENVIRONMENTAL BIOLOGY OF FISHES LA English DT Article DE Atlantic sturgeon; Sturgeon spine; Sr/Ca ratio; Diadromy; EDXRF ID OTOLITH MICROCHEMISTRY; SR/CA RATIOS; STRONTIUM; FISH; AGE AB Atlantic sturgeon migrate between ocean and freshwater habitats to spawn, and juveniles spend several years in fresh/brackish water before returning to the ocean. Because strontium/calcium (Sr/Ca) ratios are diagnostic for freshwater and marine environments, we examined the utility of energy-dispersive x-ray fluorescence (EDXRF) to quantify Sr/Ca ratios of Atlantic sturgeon pectoral fin spines. Atlantic sturgeon spines from wild adults and experimental juveniles were analyzed along a linear transect from the primordium to the outermost point. To verify the technique hatchery juvenile Atlantic sturgeon were held in experimental tanks at < 0.5, 13-15, or 33-35aEuro degrees and sampled after 5 months. Sr/Ca ratios of experimental hatchery fish increased with salinity, and Sr/Ca ratios in wild adults varied predictably along the measurement transect. However, the ratio decreased in the outermost region of the spine in mature fish collected during a return to freshwater for spawning. Therefore EDXRF is a useful tool to track individual movements of Atlantic sturgeons and other diadromous fish. C1 [Balazik, Matthew T.; McIninch, Stephen P.; Garman, Greg C.] Virginia Commonwealth Univ, Ctr Environm Studies, Richmond, VA 23284 USA. [Fine, Michael L.] Virginia Commonwealth Univ, Dept Biol, Richmond, VA 23284 USA. [Smith, Clint B.] USA, Engineer Res & Dev Ctr, Geospatial Res & Engn Div Alexandria, Alexandria, VA 22315 USA. RP Balazik, MT (reprint author), Virginia Commonwealth Univ, Ctr Environm Studies, 1000 W Cary St, Richmond, VA 23284 USA. EM balazikmt@vcu.edu NR 19 TC 2 Z9 2 U1 0 U2 30 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0378-1909 J9 ENVIRON BIOL FISH JI Environ. Biol. Fishes PD OCT PY 2012 VL 95 IS 2 BP 191 EP 194 DI 10.1007/s10641-012-9979-3 PG 4 WC Ecology; Marine & Freshwater Biology SC Environmental Sciences & Ecology; Marine & Freshwater Biology GA 000DD UT WOS:000308365800001 ER PT J AU Lynch, SM Fritch, A Heath, NM AF Lynch, Shannon M. Fritch, April Heath, Nicole M. TI Looking Beneath the Surface: The Nature of Incarcerated Women's Experiences of Interpersonal Violence, Treatment Needs, and Mental Health SO FEMINIST CRIMINOLOGY LA English DT Article DE incarcerated women; interpersonal violence; treatment needs ID POSTTRAUMATIC-STRESS-DISORDER; NATIONAL COMORBIDITY SURVEY; INTIMATE PARTNER VIOLENCE; SEXUAL-ABUSE; INMATES; ILLNESS; PROGRAM; PTSD; JAIL AB Female offenders report higher rates of interpersonal violence (IPV) and mental health problems than incarcerated men. The purpose of this study was to describe the nature of incarcerated women's (N = 102) IPV experiences, to investigate characteristics of IPV as predictors of current mental health, and to explore women's perceptions of their treatment needs. Utilizing multivariate multiple regression analyses, the authors found that recent partner violence, multiple types of IPV, chronic IPV, and distress at the time of the IPV were all significant predictors of current mental health. In narrative responses, participants recognized the connection between IPV and their mental health and indicated a need for trauma-informed interventions. C1 [Lynch, Shannon M.] Idaho State Univ, Pocatello, ID 83209 USA. [Fritch, April] Tripler Army Med Ctr, Honolulu, HI 96859 USA. [Heath, Nicole M.] Rush Univ, Med Ctr, Dept Behav Sci, Chicago, IL 60612 USA. RP Lynch, SM (reprint author), Idaho State Univ, 921 So 8th Ave,Stop 8112, Pocatello, ID 83209 USA. EM lyncshan@isu.edu NR 33 TC 25 Z9 25 U1 1 U2 17 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 1557-0851 J9 FEM CRIMINOL JI Fem. Criminol. PD OCT PY 2012 VL 7 IS 4 BP 381 EP 400 DI 10.1177/1557085112439224 PG 20 WC Criminology & Penology SC Criminology & Penology GA 997TC UT WOS:000308188200006 ER PT J AU Shiels, S Oh, S Bae, C Guda, T Singleton, B Dean, DD Wenke, JC Appleford, MR Ong, JL AF Shiels, Stefanie Oh, Sunho Bae, Chunsik Guda, Teja Singleton, Brian Dean, David D. Wenke, Joseph C. Appleford, Mark R. Ong, Joo L. TI Evaluation of BMP-2 tethered polyelectrolyte coatings on hydroxyapatite scaffolds in vivo SO JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS LA English DT Article DE bone; in vivo; scaffolds; rhBMP-2; polyelectrolyte ID BONE MORPHOGENETIC PROTEINS; CALCIUM-PHOSPHATE CERAMICS; ILIAC CREST; REPAIR; DELIVERY; DIFFERENTIATION; DEFECTS; CARRIER; FUSION; MARROW AB The goal of this in vivo study was to evaluate the osteoinductive and angio-inductive properties of a porous hydroxyapatite (HAp) scaffold with immobilized recombinant bone morphogenetic protein-2 (rhBMP-2) on the surface. It was hypothesized in this study that the use of a rhBMP-2 incorporated polyelectrolyte coating on the HAp scaffold would allow for controlled exposure of rhBMP-2 into the tissue and would provide a sound platform for tissue growth. The scaffolds were characterized for porosity and interconnectivity using pycnometry, scanning electron microscopy and micro-ct. These scaffolds were then divided into the following four groups: (a) HAp scaffold (n-HAp group), (b) rhBMP-2 physically adsorbed on HAp scaffold (HAp-BMP-2 Group), (c) polyelectrolyte coating on HAp scaffold without rhBMP-2 (HAp-PEI Scaffold Group), and (d) polyelectrolyte coating tethered with rhBMP-2 on HAp scaffold (HAp-PEI-BMP-2 Scaffold Group). Using 18 skeletally matured New Zealand white rabbits, these scaffolds were evaluated in a nonload bearing femoral condyle plug model. The negative controls for this study have defects that were left untreated and the positive controls have defects that were filled with autologous bone graft harvested from epsilateral iliac crest. Bone induction, vessel growth, and scaffold-bone contact were analyzed after 8-week implantation using micro-CT and histomorphometry. It was concluded from this study that the use of scaffold with an attached rhBMP-2 increased the vascularization around the implant when compared with the uncoated n-HAp scaffold, a necessary step of bone regeneration. The open-pore HAp scaffold was also concluded to provide a platform for tissue growth, drug loading, and tissue interaction. (C) 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2012. C1 [Shiels, Stefanie; Oh, Sunho; Guda, Teja; Singleton, Brian; Appleford, Mark R.; Ong, Joo L.] Univ Texas San Antonio, Dept Biomed Engn, San Antonio, TX 78249 USA. [Shiels, Stefanie; Singleton, Brian; Dean, David D.; Appleford, Mark R.; Ong, Joo L.] UTSA UTHSCSA Joint Grad Program Biomed Engn, San Antonio, TX USA. [Dean, David D.] Univ Texas Hlth Sci Ctr San Antonio, Dept Orthopaed, San Antonio, TX 78229 USA. [Wenke, Joseph C.] USA, Inst Surg Res, San Antonio, TX USA. [Bae, Chunsik] Chonnam Natl Univ, Coll Vet Med, Kwangju, South Korea. RP Shiels, S (reprint author), Univ Texas San Antonio, Dept Biomed Engn, San Antonio, TX 78249 USA. EM scrumlett@gmail.com RI Guda, Teja/A-7286-2009; OI Guda, Teja/0000-0002-3218-2916; Shiels, Stefanie/0000-0002-5904-3107; Dean, David/0000-0002-4512-9065 FU US Army Medical Research and Material Command [W81XWH-08-1-0393] FX Contract grant sponsor: OTRP funding from the US Army Medical Research and Material Command; contract grant number: W81XWH-08-1-0393 NR 33 TC 6 Z9 6 U1 1 U2 12 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1552-4973 J9 J BIOMED MATER RES B JI J. Biomed. Mater. Res. Part B PD OCT PY 2012 VL 100B IS 7 BP 1782 EP 1791 DI 10.1002/jbm.b.32745 PG 10 WC Engineering, Biomedical; Materials Science, Biomaterials SC Engineering; Materials Science GA 000QU UT WOS:000308403200008 PM 22807331 ER PT J AU Scott, PT Hakre, S Myles, O Sanders-Buell, EE Kijak, GH McCutchan, FE O'Connell, RJ Peel, SA Eggleston, JC Sateren, WB Robb-McGrath, M Mott, RL Tobler, SK Nolan, E Petruccelli, BP Michael, NL Cersovsky, SB AF Scott, Paul T. Hakre, Shilpa Myles, Otha Sanders-Buell, Eric E. Kijak, Gustavo H. McCutchan, Francine E. O'Connell, Robert J. Peel, Sheila A. Eggleston, J. Connor Sateren, Warren B. Robb-McGrath, Micaela Mott, Robert L. Tobler, Steven K. Nolan, Eileen Petruccelli, Bruno P. Michael, Nelson L. Cersovsky, Steven B. TI Investigation of Incident HIV Infections Among US Army Soldiers Deployed to Afghanistan and Iraq, 2001-2007 SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Article ID SEXUALLY-TRANSMITTED-DISEASES; MILITARY PERSONNEL; ENDURING-FREEDOM; WHOLE-BLOOD; TRANSFUSION; SEROCONVERSION AB The U.S. Army initiated an investigation in response to observations of a possible increase in HIV incidence among soldiers deployed to combat. Human immunodeficiency virus (HIV)-infected U.S. Army soldiers are not eligible to deploy. Combat presents a health hazard to HIV-infected soldiers and they pose a threat to the safety of the battlefield blood supply and their contacts. All soldiers are routinely screened for HIV every 2 years and those who deploy are also screened both prior to and after deployment. Seroconversion rates were estimated for all soldiers who deployed to Afghanistan or Iraq in the period 2001-2007 and all active duty soldiers who did not. Seroconverters with an estimated date of infection, based on calculation of the midpoint between the last seronegative and first seropositive test date, that was either before or during deployment were eligible for inclusion. Confidential interviews and medical record reviews were conducted to determine the most likely time, geographic location, and mode of infection. Reposed predeployment samples were tested for HIV ribonucleic acid. The HIV seroconversion rate among all soldiers who deployed was less than the rate among those who did not deploy: 1.04 and 1.42 per 10,000 person-years, respectively. Among 48 cases, most were determined to have been infected in the United States or Germany and prior to deployment (n = 20, 42%) or during rest and relaxation leave (n = 13, 27%). Seven seronegative acute infections were identified in the predeployment period. Subtype was determined for 40 individuals; all were subtype B infections. All were acquired through sexual contact. These findings can inform development of preventive interventions and refinement of existing screening policy to further reduce HIV-infected deployed soldier person time. C1 [Scott, Paul T.; Myles, Otha; O'Connell, Robert J.; Peel, Sheila A.; Sateren, Warren B.; Michael, Nelson L.] Walter Reed Army Inst Res, US Mil HIV Res Program, Bethesda, MD 20817 USA. [Hakre, Shilpa; Sanders-Buell, Eric E.; Kijak, Gustavo H.; McCutchan, Francine E.; Eggleston, J. Connor; Robb-McGrath, Micaela; Nolan, Eileen; Petruccelli, Bruno P.] Henry M Jackson Fdn Adv Mil Med, US Mil HIV Res Program, Bethesda, MD USA. [Mott, Robert L.] Off US Army Surgeon Gen, Falls Church, VA USA. [Tobler, Steven K.] Armed Forces Hlth Surveillance Ctr, Silver Spring, MD USA. [Cersovsky, Steven B.] US Army Publ Hlth Command, Aberdeen Proving Ground, MD USA. RP Scott, PT (reprint author), Walter Reed Army Inst Res, US Mil HIV Res Program, 6720A Rockledge Dr,Suite 400, Bethesda, MD 20817 USA. EM pscott@hivresearch.org FU United States Army Public Health Command FX This work was supported by funds from the United States Army Public Health Command, formerly the United States Army Center for Health Promotion and Preventive Medicine. These data were presented in part at the National STD Prevention Conference, Atlanta, GA, March 8-11,2010. NR 21 TC 6 Z9 6 U1 0 U2 1 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0889-2229 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD OCT PY 2012 VL 28 IS 10 BP 1308 EP 1312 DI 10.1089/aid.2011.0363 PG 5 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA 013TV UT WOS:000309329700022 PM 22280248 ER PT J AU Patil, S Rustgi, A Watson, J Betteridge, J Szeto, W Cheevers, N Flasar, M Skup, M Yang, M Chao, JD Mulani, P Cross, R AF Patil, Seema Rustgi, Ankur Watson, Joshua Betteridge, John Szeto, Winnie Cheevers, Nadia Flasar, Mark Skup, Martha Yang, Mei Chao, Jingdong Mulani, Parvez Cross, Raymond TI Predictors of Disability in Patients with Crohn's Disease SO AMERICAN JOURNAL OF GASTROENTEROLOGY LA English DT Meeting Abstract C1 [Patil, Seema; Rustgi, Ankur; Cheevers, Nadia; Flasar, Mark; Cross, Raymond] Univ Maryland, College Pk, MD 20742 USA. [Watson, Joshua] Dwight D Eisenhower Army Med Ctr, Ft Gordon, GA USA. [Betteridge, John; Szeto, Winnie] Walter Reed Natl Mil Med Ctr, Bethesda, MD USA. [Skup, Martha; Yang, Mei; Chao, Jingdong; Mulani, Parvez] Abbott Labs, Abbott Pk, IL 60064 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 0002-9270 EI 1572-0241 J9 AM J GASTROENTEROL JI Am. J. Gastroenterol. PD OCT PY 2012 VL 107 SU 1 MA 1612 BP S651 EP S651 PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA V30UA UT WOS:000208839702496 ER PT J AU Heinrich, KM Spencer, V Fehl, N Poston, WSC AF Heinrich, Katie M. Spencer, Vincent Fehl, Nathanael Poston, Walker S. Carlos TI Mission Essential Fitness: Comparison of Functional Circuit Training to Traditional Army Physical Training for Active Duty Military SO MILITARY MEDICINE LA English DT Article AB Appropriate and effective physical fitness training is imperative for soldier survival and mission success. The purpose of this study was to determine the effects of Mission Essential Fitness (MEF) circuit-style training program compared to standard Army Physical Readiness Training (APRT) on fitness, physiological, and body composition changes. Active duty Army personnel were randomly assigned to two groups (MEF = 34 or APRT = 33) for 8 weeks of training (15 sessions each). The MEF program included functional movements focused on strength, power, speed, and agility. Fifteen exercises were performed continuously for 60 to 90 seconds for 45 minutes. Baseline and post-test measures included the Army physical fitness test, physiological indicators, body composition, and additional fitness indicators. One-way analysis of covariance models indicated that MEP participants significantly increased their push-ups (p = 0.033), bench press (p = 0.001), and flexibility (p = 0.003) and significantly decreased their 2-mile run (p = 0.003) and step test heart rate (p = 0.004) compared to participants doing APRT. Both groups maintained body composition (p > 0.05) and reported no injuries. The MEF training program safely improved muscular strength and endurance, cardiovascular endurance, and flexibility, supporting functional fitness circuit-style exercise training for military personnel. C1 [Heinrich, Katie M.; Fehl, Nathanael] Kansas State Univ, Dept Kinesiol, Funct Intens Training Lab, Manhattan, KS 66506 USA. [Spencer, Vincent] US Army, Fitness Dept, Directorate Family Morale Welf & Recreat, Fort Riley, KS 66442 USA. [Poston, Walker S. Carlos] Inst Biobehav Hlth Res, Natl Dev & Res Inst, Leawood, KS 66224 USA. RP Heinrich, KM (reprint author), Kansas State Univ, Dept Kinesiol, Funct Intens Training Lab, Natatorium 4, Manhattan, KS 66506 USA. RI Heinrich, Katie/B-4782-2013 OI Heinrich, Katie/0000-0002-6837-408X NR 25 TC 15 Z9 16 U1 1 U2 2 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD OCT PY 2012 VL 177 IS 10 BP 1125 EP 1130 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA V33OE UT WOS:000209027300006 PM 23113436 ER PT J AU Johnson, D Corrigan, T Gulickson, G Holshouser, E Johnson, S AF Johnson, Don Corrigan, Theresa Gulickson, Gary Holshouser, Elizabeth Johnson, Sabine TI The Effects of a Human Patient Simulator vs. a CD-ROM on Performance SO MILITARY MEDICINE LA English DT Article AB Objectives: Military health care personnel need to have skills relative to caring for patients on the battlefield. No studies have compared the two teaching strategies of using the human patient simulator (HPS) and a CD-ROM in caring for combat injuries. The objective of this study was to determine if there were statistically significant differences in HIPS and CD-ROM educational strategies relative to caring for patients who have trauma. Methods: A pretest/post-test prospective experimental design was used. Anesthesia students were randomly assigned to one of three groups: HPS, CD-ROM, or a control group. A valid and reliable instrument, Combat Performance, was used to evaluate the participant's ability to give care to trauma patients. Results: A repeated analysis of variance and a least significant difference post hoc test were used to analyze the data. The HPS group performed better than the CD-ROM and control groups relative to performance (p = 0.001). There was no difference between the CD-ROM and control group (p = 0.171). Discussion: We speculate that the HPS group performed better than the CD-ROM group because of the realism. Conclusion: In this study, the HPS method of instruction was a more effective method of teaching than the CD-ROM approach. C1 [Johnson, Don; Corrigan, Theresa; Gulickson, Gary; Holshouser, Elizabeth; Johnson, Sabine] US Army, Acad Hlth Sci, Dept Army, Grad Program Anesthesia Nursing, Ft Sam Houston, TX 78234 USA. RP Johnson, D (reprint author), US Army, Acad Hlth Sci, Dept Army, Grad Program Anesthesia Nursing, 3490 Forage Rd, Ft Sam Houston, TX 78234 USA. FU U.S. Army Graduate Program in Anesthesia Nursing; TriService Nursing Research Program FX We acknowledge the U.S. Army Graduate Program in Anesthesia Nursing and the TriService Nursing Research Program for their support of this study. This study was funded by the TriService Nursing Research Program. NR 27 TC 2 Z9 2 U1 0 U2 1 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD OCT PY 2012 VL 177 IS 10 BP 1131 EP 1135 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA V33OE UT WOS:000209027300007 PM 23113437 ER PT J AU Warr, BJ Heumann, KJ Dodd, DJ Swan, PD Alvar, BA AF Warr, Bradley J. Heumann, Kristin J. Dodd, Daniel J. Swan, Pamela D. Alvar, Brent A. TI Injuries, Changes in Fitness, and Medical Demands in Deployed National Guard Soldiers SO MILITARY MEDICINE LA English DT Article AB Purpose: To characterize noncombat injury/illness, determine changes in physical fitness, and evaluate the influence of these changes on medical resource utilization by National Guard (NG) Soldiers. Methods: Fifty-four Soldiers from the Arizona NG completed pre- and postdeployment fitness testing. Additionally, individual deployment medical records were inventoried. Results: The majority of noncombat-related medical visits (41%) were musculoskeletal in nature, followed by miscellaneous (33%) and respiratory (13%). Soldiers experienced significant decreases in percent fat mass (-11.1%, p < 0.001) and VO2 peak (-10.8%, p < 0.001). There were significant increases in push-ups (16.4%, p < 0.001), sit-ups (11.0%, p = 0.001), bench-press (10.2%, p < 0.001), and back squat (14.2%, p < 0.001) measures. VO2 peak was inversely correlated to medical resource utilization (r = -0.45 to -0.28, p <= 0.05). The tertile of Soldiers experiencing the sharpest declines in VO2 peak had significantly more medical visits over the course of the deployment than the other two tertiles (8.0 vs. 2.6 vs. 3.1 medical visits/Soldier, p <= 0.05). Conclusion: The predominate noncombat medical issue was musculoskeletal injury. NG Soldiers improved their body composition, strength, and endurance but experienced significant declines in aerobic fitness while deployed. These data document the association between declining aerobic fitness and increased utilization of medical resources. C1 [Warr, Bradley J.] US Army, Res Inst Environm Med, Mil Performance Div, Natick, MA 01760 USA. [Warr, Bradley J.; Heumann, Kristin J.; Swan, Pamela D.] Arizona State Univ, Healthy Lifestyles Res Ctr, Exercise & Wellness Program, Phoenix, AZ 85004 USA. [Heumann, Kristin J.] Colorado Mesa Univ, Dept Kinesiol, Grand Junction, CO 81501 USA. [Dodd, Daniel J.] Chandler Gilbert Community Coll, Human Performance Lab, Mesa, AZ 85225 USA. [Alvar, Brent A.] Rocky Mt Univ Hlth Profess, Provo, UT 84606 USA. RP Warr, BJ (reprint author), US Army, Res Inst Environm Med, Mil Performance Div, Bldg 42,Kansas St, Natick, MA 01760 USA. FU American College of Sports Medicine; U.S. Army Research Institute of Environmental Medicine FX We acknowledge the Arizona National Guard for their cooperation and participation in this research. This study was supported in part by a Doctoral Student Research Grant from the American College of Sports Medicine and the U.S. Army Research Institute of Environmental Medicine. NR 28 TC 4 Z9 4 U1 0 U2 1 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD OCT PY 2012 VL 177 IS 10 BP 1136 EP 1142 PG 7 WC Medicine, General & Internal SC General & Internal Medicine GA V33OE UT WOS:000209027300008 PM 23113438 ER PT J AU Riviere, LA Merrill, JC Thomas, JL Wilk, JE Bliese, PD AF Riviere, Lyndon A. Merrill, Julie C. Thomas, Jeffrey L. Wilk, Joshua E. Bliese, Paul D. TI 2003-2009 Marital Functioning Trends Among US Enlisted Soldiers Following Combat Deployments SO MILITARY MEDICINE LA English DT Article AB Objective: This study examined 2003-2009 trends in three marital functioning indicators: marital quality, infidelity, and separation/divorce intent, and in marital dissolution rates among U.S. soldiers. Methods: Marital functioning trends were examined with cross-sectional postdeployment sample data collected under the Land Combat Study from married, male, enlisted soldiers who had deployed to Iraq or Afghanistan (n = 5,928). Marital dissolution rates were examined with population data (n = 1,895,571). The relationships between time (measured by year) and all study variables were analyzed with chi(2) tests of association, analysis of variance, and logistic regression analyses adjusting for combat exposure, mental and physical health, and demographic variables. Results: Marital quality has declined, and reports of past-year infidelity and separation/divorce intent have increased between 2003 and 2009. However, no increases were observed in marital dissolution rates. Conclusions: The results indicate that more proximal indicators of marital functioning such as decreased marital quality, infidelity, and separation/divorce intent may better illustrate the strain that increased deployment tempo exerts on marital relationships. The findings provide a better understanding of how Army marriages have been affected by the wars, and suggest that further inquiry is needed on military marriages. C1 [Riviere, Lyndon A.; Merrill, Julie C.; Thomas, Jeffrey L.; Wilk, Joshua E.; Bliese, Paul D.] Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci, Silver Spring, MD 20910 USA. RP Riviere, LA (reprint author), Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. FU Military Operational Medicine Research Area Directorate, U.S. Army Medical Research and Materiel Command, Fort Detrick, MD FX The authors thank Kristina Clarke-Walper and Brian Kok for their invaluable assistance in formatting tables and assembling references. We also thank past and present members of the Land Combat Study team for their inestimable contributions to the study. Additionally, we are grateful to the Data Manpower Data Center for provision of the data on marital dissolution rates. Funding for this project came from the Military Operational Medicine Research Area Directorate, U.S. Army Medical Research and Materiel Command, Fort Detrick, MD. NR 43 TC 9 Z9 9 U1 0 U2 3 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD OCT PY 2012 VL 177 IS 10 BP 1169 EP 1177 PG 9 WC Medicine, General & Internal SC General & Internal Medicine GA V33OE UT WOS:000209027300013 PM 23113443 ER PT J AU Franzos, MA Franzos, TL Wooford, JS McDonald, WA AF Franzos, M. Alaric Franzos, Tracy L. Wooford, Jeffrey S. McDonald, William A. TI Alcohol Abuse or Dependence in the Military Aviator: Guidance for the Non-Flight Surgeon SO MILITARY MEDICINE LA English DT Article AB Alcohol is tightly interwoven with the image and culture of aviation. When alcohol is combined with aviation, the result can be fatal to aircrew, passengers, and bystanders. Alcohol has been implicated in 8 to 12% of fatal general aviation accidents.(1,2) With approximately 10% of the general population estimated to have alcohol abuse or dependence,3 alcohol issues are similarly common among aviators. Clear and concise guidelines exist to address alcohol disorders in both civilian and military aviation. However, few health care providers outside the aviation community are aware of these guidelines. When an aviator presents with an alcohol disorder, the well-intentioned provider may be reluctant to address the issue because of poor understanding of the occupational implications Or a misplaced effort to preserve the aviator's career. However, proper therapy often permits the aviator to continue flying duties without adverse career impact. This review will discuss the implications, guidelines, and prognosis for the alcohol-dependent aviator and provide resources to enable the responsible health care provider to return the pilot to flight status as soon as practicable. Knowledge of these civilian and military guidelines will help close the treatment and communication gaps between aeromedical specialists and other medical professionals. C1 [Franzos, M. Alaric] Walter Reed Natl Mil Med Ctr, Dept Cardiol, Bethesda, MD 20889 USA. [Franzos, Tracy L.] Tripler Army Med Ctr, Dept Family Med, Honolulu, HI 96859 USA. [Wooford, Jeffrey S.] Spangdahlem Air Base, Med Grp 52, APO, AE 09123 USA. [McDonald, William A.] Naval Aerosp Med Inst, Dept Clin Med 32, Pensacola, FL 32508 USA. RP Franzos, MA (reprint author), Walter Reed Natl Mil Med Ctr, Dept Cardiol, 8901 Wisconsin Ave, Bethesda, MD 20889 USA. NR 19 TC 0 Z9 0 U1 0 U2 0 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD OCT PY 2012 VL 177 IS 10 BP 1191 EP 1195 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA V33OE UT WOS:000209027300016 PM 23113446 ER PT J AU Hommer, DH AF Hommer, Dean H. TI Chinese Scalp Acupuncture Relieves Pain and Restores Function in Complex Regional Pain Syndrome SO MILITARY MEDICINE LA English DT Article AB Complex Regional Pain Syndrome (CRPS) can result from trauma or after surgery. It is often difficult to manage effectively. If not recognized early, it can result in significant debilitation. Symptoms attributed to CRPS include neuropathic pain, allodynia, sudomotor changes, and decreased range of motion. It can occur with (Type II) or without (Type I) nerve injury. A number of soldiers sustaining extremity injuries during combat have manifested these symptoms. Two subjects were diagnosed with CRPS after sustaining upper extremity injuries during military operations. After failing conservative treatment, Chinese Scalp Acupuncture (CSA) was used once to twice a week for 1 to 4 weeks. CSA resulted in improvement in the pain visual analog scale or numeric rating scale by over 80% in two soldiers with upper extremity CRPS. Additionally, decreased sensory changes and improved function were noted on exam and therapy assessments. Notably, the pain reduction, functional improvement, and normalization of sensation have been fully maintained between treatments. The treatment response had been sustained at 20-month follow-up with no recurrence. CSA provided lasting pain reduction, and improved function and sensation in this group of combatants with upper extremity CRPS. C1 Brooke Army Med Ctr, Dept Orthoped & Rehabil, Phys Med & Rehabil Serv, Ft Sam Houston, TX 78234 USA. RP Hommer, DH (reprint author), Brooke Army Med Ctr, Dept Orthoped & Rehabil, Phys Med & Rehabil Serv, 3551 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. NR 9 TC 6 Z9 7 U1 1 U2 2 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD OCT PY 2012 VL 177 IS 10 BP 1231 EP 1234 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA V33OE UT WOS:000209027300024 PM 23113454 ER PT J AU Berman, M AF Berman, Morris TI A MATLAB Tool for Experimental and Analytical Shock and Vibration Data SO SOUND AND VIBRATION LA English DT Article AB A new MATLAB (R) tool provides the shock and vibration community with the ability to display and analyze data while minimizing the probability of bookkeeping errors. C1 US Army Res Lab, Adelphi, MD 20783 USA. RP Berman, M (reprint author), US Army Res Lab, Adelphi, MD 20783 USA. EM morris.berman@us.army.mil NR 4 TC 0 Z9 0 U1 1 U2 3 PU ACOUSTICAL PUBL INC PI BAY VILLAGE PA 27101 E OVIATT RD, PO BOX 40416, BAY VILLAGE, OH 44140 USA SN 1541-0161 J9 SOUND VIB JI Sound Vib. PD OCT PY 2012 VL 46 IS 10 BP 5 EP 9 PG 5 WC Acoustics; Engineering, Mechanical; Mechanics SC Acoustics; Engineering; Mechanics GA V33XB UT WOS:000209050400002 ER PT J AU Makar, JR Myers, TM AF Makar, J. R. Myers, T. M. TI USE OF COMPUTERIZED OPERANT BEHAVIOR TESTING FOR EVALUATING SURGICAL RECOVERY IN AFRICAN GREEN MONKEYS (CHLOROCEBUS AETHIOPS SABEUS) SO AMERICAN JOURNAL OF PRIMATOLOGY LA English DT Meeting Abstract CT 35th Meeting of the American-Society-of-Primatologists (ASP) CY JUN 20-23, 2012 CL Sacramento, CA SP Amer Soc Primatol (ASP), Calilf Natl Primate Res Ctr C1 [Makar, J. R.; Myers, T. M.] USA, Neurobehav Toxicol Branch, Analyt Toxicol Div, Med Res Inst Chem Def, Aberdeen Proving Ground, MD 21010 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0275-2565 J9 AM J PRIMATOL JI Am. J. Primatol. PD OCT PY 2012 VL 74 SU 1 MA 105 BP 58 EP 58 PG 1 WC Zoology SC Zoology GA 991UT UT WOS:000307728700103 ER PT J AU Sutorik, AC Green, MD Cooper, C Wolfenstine, J Gilde, G AF Sutorik, Anthony C. Green, Matthew D. Cooper, Christopher Wolfenstine, Jeffrey Gilde, Gary TI The comparative influences of structural ordering, grain size, Li-content, and bulk density on the Li+-conductivity of Li0.29La0.57TiO3 SO JOURNAL OF MATERIALS SCIENCE LA English DT Article ID LITHIUM ION CONDUCTIVITY; A-SITE IONS; PEROVSKITE; LA0.67-XLI3XTIO3; CERAMICS; TITANATE; OXIDES AB The lattice and total Li+-ionic conductivity of Li0.29La0.57TiO3 ceramic (LLTO) sintered at 1200 A degrees C were determined as functions of powder calcination temperature and sintering duration, and these results were correlated with the relative degrees of Li+-ordering, Li-content, grain size, and bulk density to assess the relative impact of these parameters on material performance. Under all conditions, LLTO formed with a high degree of tetragonal superstructure to its perovskite related framework, and the lattice conductivity closely followed the relative amounts of the superstructure, as evaluated via determination of the sample ordering parameter from X-ray diffraction data. LLTO powders that were calcined at 900 A degrees C for 1 h and sintered at 1200 A degrees C for 6 h gave lattice conductivity values (similar to 1.14 x 10(-3) S cm(-1)) comparable within the highest ranges reported in the literature. This coincided with the lowest degree of tetragonal superstructure formation, and it was also found to be largely independent of the values of Li-content measured on sintered ceramic despite significant Li2O volatilization at longer sintering times (up to 23 % after 12 h at 1200 A degrees C). Samples of LLTO powder that were calcined at 1100 A degrees C and sintered at 1200 A degrees C for 12 h resulted in the highest total Li-ion conductivity value similar to 6.30 x 10(-5) S cm(-1). The total conductivity of LLTO varied inversely with grain size when the grains were < 20 mu m but was insensitive to that parameter above that size threshold. The strongest influence on total conductivity was primarily the bulk ceramic density. It was estimated from measured values that as the bulk ceramic density approached the full theoretical value for LLTO the total conductivity could near the lattice conductivity of similar to 1.2 x 10(-3) S cm(-1). C1 [Sutorik, Anthony C.; Green, Matthew D.; Cooper, Christopher; Gilde, Gary] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. [Wolfenstine, Jeffrey] USA, Res Lab, Adelphi, MD 20783 USA. RP Sutorik, AC (reprint author), USA, Res Lab, RDRL WMM E,Bldg 4600, Aberdeen Proving Ground, MD 21005 USA. EM anthony.sutorik1@us.army.mil NR 20 TC 6 Z9 7 U1 2 U2 47 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0022-2461 J9 J MATER SCI JI J. Mater. Sci. PD OCT PY 2012 VL 47 IS 19 BP 6992 EP 7002 DI 10.1007/s10853-012-6650-5 PG 11 WC Materials Science, Multidisciplinary SC Materials Science GA 974LK UT WOS:000306436600026 ER PT J AU Haile, M Chen, TK Sediles, F Shiao, M Le, D AF Haile, Mulugeta Chen, Tzi-Kang Sediles, Felipe Shiao, Michael Le, Dy TI Estimating crack growth in rotorcraft structures subjected to mission load spectrum SO INTERNATIONAL JOURNAL OF FATIGUE LA English DT Article DE Mission spectrum load; Crack closure; Effect of friction on crack growth rate ID FATIGUE AB This paper is an extension of the work originally reported on the international conference of experimental mechanics. In this extended work, numerical and experimental results are presented from a project aimed at predicting the fatigue life of a rotorcraft structural component subjected to flight load spectrum. The structural component is a riveted joint used in cabin frame cap splices of several civilian and military helicopters modeled herein as a lap-joined nested angle assembly. This component is fatigue sensitive due to the highly cyclic and vibratory nature of a rotorcraft mission load spectrum and as such accurate prediction of its fatigue life is of major importance in the design cycle. In this work, numerical studies are conducted using constant amplitude and mission spectrum loads. The rate of fatigue crack growth for through-the-thickness crack initiated from the critical fastener hole is computed using 2D standard and weight function models with the crack plane stress field obtained from 3D finite element analysis. Effect of load interaction due to tensile overload is included using strip-yield retardation model and the effect of surface shear arising from contact friction between the plates and the fasteners is studied using parametric models. Finally, results of the numerical simulations are compared with representative experimental data obtained under similar spectrum loading condition. Published by Elsevier Ltd. C1 [Haile, Mulugeta; Chen, Tzi-Kang; Shiao, Michael; Le, Dy] USA, Res Lab, Vehicle Technol Directorate, Aberdeen Proving Ground, MD USA. [Sediles, Felipe] Natl Inst Aerosp, Hampton, VA USA. RP Haile, M (reprint author), USA, Res Lab, Vehicle Technol Directorate, Aberdeen Proving Ground, MD USA. EM mulugeta.a.haile@us.army.mil NR 16 TC 4 Z9 4 U1 1 U2 16 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0142-1123 J9 INT J FATIGUE JI Int. J. Fatigue PD OCT PY 2012 VL 43 BP 142 EP 149 DI 10.1016/j.ijfatigue.2012.03.009 PG 8 WC Engineering, Mechanical; Materials Science, Multidisciplinary SC Engineering; Materials Science GA 957MB UT WOS:000305166000016 ER PT J AU Mariani, MC Bianchini, A Bandini, P AF Mariani, Maria Cristina Bianchini, Alessandra Bandini, Paola TI Normalized truncated Levy walk applied to flexible pavement performance SO TRANSPORTATION RESEARCH PART C-EMERGING TECHNOLOGIES LA English DT Article DE Levy flight; Levy distribution; Pavement performance; Serviceability; Flexible pavement ID STOCHASTIC-PROCESS; ECONOPHYSICS; CONVERGENCE; DYNAMICS AB Government agencies and consulting companies face the challenge of pavement management aiming to maintain pavements in serviceable condition in the long term. This paper analyzed the evolution of the performance of flexible pavements to forecast the change in the serviceability level offered by the structure. Data from the Minnesota Road Research Project (MnROAD) road test corresponding to the low-volume traffic loop were used in the study. The data analysis centered on the normalized truncated Levy walk model. It was concluded that the truncated Levy distribution optimally describes the decrease of pavement serviceability caused by traffic and climatic conditions specific to the infrastructure location and traffic. The Truncated Levy Flight (TLF) provided a better approximation over the full range of the normalized pavement serviceability index than the Gaussian distribution for dataset considered. Published by Elsevier Ltd. C1 [Bianchini, Alessandra] USA, Engn Res & Dev Ctr, Vicksburg, MS 39180 USA. [Mariani, Maria Cristina] Univ Texas El Paso, Dept Math Sci, El Paso, TX 79968 USA. [Bandini, Paola] New Mexico State Univ, Dept Civil Engn, Las Cruces, NM 88003 USA. RP Bianchini, A (reprint author), USA, Engn Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM alessandra.bianchini@usace.army.mil OI Bandini, Paola/0000-0002-9055-3017 NR 34 TC 2 Z9 3 U1 1 U2 6 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0968-090X J9 TRANSPORT RES C-EMER JI Transp. Res. Pt. C-Emerg. Technol. PD OCT PY 2012 VL 24 BP 1 EP 8 DI 10.1016/j.trc.2012.01.006 PG 8 WC Transportation Science & Technology SC Transportation GA 953FH UT WOS:000304851800001 ER PT J AU Sheng, G Bhattacharyya, S Zhang, H Chang, K Shang, SL Mathaudhu, SN Liu, ZK Chen, LQ AF Sheng, G. Bhattacharyya, S. Zhang, H. Chang, K. Shang, S. L. Mathaudhu, S. N. Liu, Z. K. Chen, L. Q. TI Effective elastic properties of polycrystals based on phase-field description SO MATERIALS SCIENCE AND ENGINEERING A-STRUCTURAL MATERIALS PROPERTIES MICROSTRUCTURE AND PROCESSING LA English DT Article DE Phase-field models; Magnesium; Simulation; Elastic behavior; Polycrystal ID COMPUTER-SIMULATION; SINGLE-CRYSTAL; MAGNESIUM ALLOYS; CONSTANTS; MODEL; MICROSTRUCTURES; COMPUTATION; EVOLUTION AB A combination of microelasticity, phase-field description of grain structures, and first-principles calculations is proposed to predict the effective elastic properties of polycrystals. As an example, using the single crystal elastic constants from first-principles calculations and a polycrystalline microstructure from a phase-field simulation as inputs, the effective elastic moduli of polycrystalline magnesium are obtained as a function of temperature and compared with available experimental measurements. The texture effect on the effective elastic moduli is also examined. The proposed integrated model will make it possible to model not only the temporal evolution of microstructures but also the temporal evolution of properties using the phase-field method. (C) 2012 Elsevier B.V. All rights reserved. C1 [Sheng, G.; Bhattacharyya, S.; Zhang, H.; Chang, K.; Shang, S. L.; Liu, Z. K.; Chen, L. Q.] Penn State Univ, Dept Mat Sci & Engn, University Pk, PA 16802 USA. [Mathaudhu, S. N.] USA, Res Lab, Mat & Mfg Sci Div, Aberdeen Proving Ground, MD 21005 USA. RP Sheng, G (reprint author), Sci Forming Technol Corp, Columbus, OH 43235 USA. EM shengguang1982@gmail.com RI Chen, LongQing/I-7536-2012; Shang, Shun-Li/A-6564-2009; Mathaudhu, Suveen/B-4192-2009; Liu, Zi-Kui/A-8196-2009 OI Chen, LongQing/0000-0003-3359-3781; Shang, Shun-Li/0000-0002-6524-8897; Liu, Zi-Kui/0000-0003-3346-3696 FU U.S. Army Research Laboratory [W911NF-08-2-0064]; NSF [DMR-0710483]; Instrumentation (cyberstar Linux cluster); National Science Foundation [OCI-0821527]; Materials Simulation Center; Graduate Education and Research Services at the Pennsylvania State University FX The financial support from U.S. Army Research Laboratory under contract W911NF-08-2-0064 is greatly acknowledged. The work is also partially supported by NSF under the grant number DMR-0710483 (Chang and Chen). Calculations were conducted at the LION clusters at the Pennsylvania State University and in part supported by Instrumentation (cyberstar Linux cluster) funded by the National Science Foundation through grant OCI-0821527, and in part by the Materials Simulation Center and the Graduate Education and Research Services at the Pennsylvania State University. NR 31 TC 3 Z9 3 U1 0 U2 19 PU ELSEVIER SCIENCE SA PI LAUSANNE PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND SN 0921-5093 J9 MAT SCI ENG A-STRUCT JI Mater. Sci. Eng. A-Struct. Mater. Prop. Microstruct. Process. PD SEP 30 PY 2012 VL 554 BP 67 EP 71 DI 10.1016/j.msea.2012.06.012 PG 5 WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Science & Technology - Other Topics; Materials Science; Metallurgy & Metallurgical Engineering GA 990FL UT WOS:000307616300010 ER PT J AU Narayanan, A Kehn-Hall, K Senina, S Lundberg, L Van Duyne, R Guendel, I Das, R Baer, A Bethel, L Turell, M Hartman, AL Das, B Bailey, C Kashanchi, F AF Narayanan, Aarthi Kehn-Hall, Kylene Senina, Svetlana Lundberg, Lindsay Van Duyne, Rachel Guendel, Irene Das, Ravi Baer, Alan Bethel, Laura Turell, Michael Hartman, Amy Lynn Das, Bhaskar Bailey, Charles Kashanchi, Fatah TI Curcumin Inhibits Rift Valley Fever Virus Replication in Human Cells SO JOURNAL OF BIOLOGICAL CHEMISTRY LA English DT Article ID NF-KAPPA-B; NONSTRUCTURAL PROTEIN NSS; IKK-BETA; PROTEASOME EXPRESSION; P65 PHOSPHORYLATION; MEDIATED ACTIVATION; SIGNALING PATHWAYS; VIRAL REPLICATION; INDUCED APOPTOSIS; DOWN-REGULATION AB Rift Valley fever virus (RVFV) is an arbovirus that is classified as a select agent, an emerging infectious virus, and an agricultural pathogen. Understanding RVFV-host interactions is imperative to the design of novel therapeutics. Here, we report that an infection by the MP-12 strain of RVFV induces phosphorylation of the p65 component of the NF kappa B cascade. We demonstrate that phosphorylation of p65 (serine 536) involves phosphorylation of I kappa B alpha and occurs through the classical NF kappa B cascade. A unique, low molecular weight complex of the IKK-beta subunit can be observed in MP-12-infected cells, which we have labeled IKK-beta 2. The IKK-beta 2 complex retains kinase activity and phosphorylates an I kappa B alpha substrate. Inhibition of the IKK complex using inhibitors impairs viral replication, thus alluding to the requirement of an active IKK complex to the viral life cycle. Curcumin strongly down-regulates levels of extracellular infectious virus. Our data demonstrated that curcumin binds to and inhibits kinase activity of the IKK-beta 2 complex in infected cells. Curcumin partially exerts its inhibitory influence on RVFV replication by interfering with IKK-beta 2-mediated phosphorylation of the viral protein NSs and by altering the cell cycle of treated cells. Curcumin also demonstrated efficacy against ZH501, the fully virulent version of RVFV. Curcumin treatment down-regulated viral replication in the liver of infected animals. Our data point to the possibility that RVFV infection may result in the generation of novel versions of host components (such as IKK-beta 2) that, by virtue of altered protein interaction and function, qualify as unique therapeutic targets. C1 [Narayanan, Aarthi; Kehn-Hall, Kylene; Senina, Svetlana; Lundberg, Lindsay; Van Duyne, Rachel; Guendel, Irene; Das, Ravi; Baer, Alan; Bailey, Charles; Kashanchi, Fatah] George Mason Univ, Natl Ctr Biodef & Infect Dis, Manassas, VA 20110 USA. [Van Duyne, Rachel] George Washington Univ, Dept Microbiol Immunol & Trop Med, Washington, DC USA. [Turell, Michael] USA, Div Virol, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. [Das, Bhaskar] Albert Einstein Coll Med, Dept Nucl Med, Bronx, NY 10461 USA. [Bethel, Laura; Hartman, Amy Lynn] Univ Pittsburgh, Reg Biocontainment Lab, Ctr Vaccine Res, Pittsburgh, PA 15261 USA. RP Kashanchi, F (reprint author), George Mason Univ, Natl Ctr Biodef & Infect Dis, Discovery Hall,Rm 182,10900 Univ Blvd,MS 1H8, Manassas, VA 20110 USA. EM fkashanc@gmu.edu RI Kehn-Hall, Kylene/I-5752-2013; OI Hartman, Amy/0000-0002-0857-2973 FU United States Department of Energy [DE-FC52-04NA25455] FX This work was supported by United States Department of Energy Grant DE-FC52-04NA25455 (to C.B. and F.K.). NR 63 TC 21 Z9 21 U1 0 U2 4 PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3996 USA SN 0021-9258 J9 J BIOL CHEM JI J. Biol. Chem. PD SEP 28 PY 2012 VL 287 IS 40 BP 33198 EP 33214 DI 10.1074/jbc.M112.356535 PG 17 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA 017PG UT WOS:000309602100011 PM 22847000 ER PT J AU Zhang, J Fromzel, V Dubinskii, M AF Zhang, J. Fromzel, V. Dubinskii, M. TI Resonantly (in-band) cladding-pumped Yb-free Er-doped fibre laser with record efficiency SO ELECTRONICS LETTERS LA English DT Article ID OUTPUT POWER AB Power scaling potential with record high efficiency for a resonantly (in-band) cladding-pumped Yb-free Er-doped eye-safe fibre laser utilising the fibre with non-clustering composition and increased cladding pump absorption is domonstrated. While pumping at 1532.5 nm by power-combined fibre-coupled spectrally-narrowed InGaAsP/InP diode laser modules, similar to 47 W of continuous-wave multimode output power at similar to 1590 nm with optical-to-optical efficiency over 77% were achieved. To the best of the authors' knowledge, this is the highest efficiency ever obtained from a cladding-pumped Yb-free Er-doped fibre laser. C1 [Zhang, J.; Fromzel, V.; Dubinskii, M.] USA, Res Lab, Adelphi, MD 20783 USA. RP Zhang, J (reprint author), USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM mark.dubinskiy.civ@mail.mil FU High Energy Laser Joint Technology Office (HEL-JTO) FX This work was partially supported by the High Energy Laser Joint Technology Office (HEL-JTO). NR 8 TC 0 Z9 0 U1 1 U2 13 PU INST ENGINEERING TECHNOLOGY-IET PI HERTFORD PA MICHAEL FARADAY HOUSE SIX HILLS WAY STEVENAGE, HERTFORD SG1 2AY, ENGLAND SN 0013-5194 J9 ELECTRON LETT JI Electron. Lett. PD SEP 27 PY 2012 VL 48 IS 20 BP 1280 EP + DI 10.1049/e1.2012.2736 PG 2 WC Engineering, Electrical & Electronic SC Engineering GA 016LR UT WOS:000309520400033 ER PT J AU Ciraci, C Poutrina, E Scalora, M Smith, DR AF Ciraci, Cristian Poutrina, Ekaterina Scalora, Michael Smith, David R. TI Second-harmonic generation in metallic nanoparticles: Clarification of the role of the surface SO PHYSICAL REVIEW B LA English DT Article ID NONLINEAR OPTICAL REFLECTION; SPLIT-RING RESONATORS; MAGNETIC METAMATERIALS; 3RD-HARMONIC GENERATION; HARMONIC GENERATION; GOLD NANOPARTICLES; HYDRODYNAMIC-MODEL; SILVER; BOUNDARY; MEDIA AB We present a numerical investigation of the second-order nonlinear optical properties of metal-based metamaterial nanoresonators. The nonlinear optical response of the metal is described by a hydrodynamic model, with the effects of electron pressure in the electron gas also taken into account. We show that as the pressure term tends to zero the amount of converted second-harmonic field tends to an asymptotic value. In this limit it becomes possible to rewrite the nonlinear surface contributions as functions of the value of the polarization vector inside the bulk region. Nonlocality thus can be incorporated into numerical simulations without actually utilizing the nonlocal equation of motion or solving for the rapidly varying fields that occur near the metal surface. We use our model to investigate the second-harmonic generation process with three-dimensional gold nanoparticle arrays and show that nanocrescents can easily attain conversion efficiencies of similar to 6.0 x 10(-8) for pumping peak intensities of a few tens of MW/cm(2). C1 [Ciraci, Cristian; Poutrina, Ekaterina; Smith, David R.] Duke Univ, Ctrr Metamat & Integrated Plasmon, Durham, NC 27708 USA. [Ciraci, Cristian; Poutrina, Ekaterina; Smith, David R.] Duke Univ, Dept Elect & Comp Engn, Durham, NC 27708 USA. [Scalora, Michael] USA, CM Bowden Res Facil, RDECOM, Redstone Arsenal, AL 35803 USA. RP Ciraci, C (reprint author), Duke Univ, Ctrr Metamat & Integrated Plasmon, Durham, NC 27708 USA. EM cristian.ciraci@duke.edu RI Smith, David/E-4710-2012 FU Air Force Office of Scientific Research (AFOSR) [FA9550-09-1-0562]; Army Research Office through a Multidisciplinary University Research Initiative [W911NF-09-1-0539] FX The authors thank Yaroslav Urzhumov for valuable discussions. This work was supported by the Air Force Office of Scientific Research (AFOSR, Grant No. FA9550-09-1-0562) and by the Army Research Office through a Multidisciplinary University Research Initiative (Grant No. W911NF-09-1-0539). NR 86 TC 29 Z9 29 U1 2 U2 57 PU AMER PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 2469-9950 EI 2469-9969 J9 PHYS REV B JI Phys. Rev. B PD SEP 27 PY 2012 VL 86 IS 11 AR 115451 DI 10.1103/PhysRevB.86.115451 PG 10 WC Physics, Condensed Matter SC Physics GA 012LV UT WOS:000309238600009 ER PT J AU Ratto-Kim, S Currier, JR Cox, JH Excler, JL Valencia-Micolta, A Thelian, D Lo, V Sayeed, E Polonis, VR Earl, PL Moss, B Robb, ML Michael, NL Kim, JH Marovich, MA AF Ratto-Kim, Silvia Currier, Jeffrey R. Cox, Josephine H. Excler, Jean-Louis Valencia-Micolta, Anais Thelian, Doris Lo, Vicky Sayeed, Eddy Polonis, Victoria R. Earl, Patricia L. Moss, Bernard Robb, Merlin L. Michael, Nelson L. Kim, Jerome H. Marovich, Mary A. TI Heterologous Prime-Boost Regimens Using rAd35 and rMVA Vectors Elicit Stronger Cellular Immune Responses to HIV Proteins Than Homologous Regimens SO PLOS ONE LA English DT Article ID VACCINIA VIRUS ANKARA; RHESUS-MONKEYS; IMMUNOGENICITY; DNA; PROTECTION; HUMANS; MICE; SIV AB We characterized prime-boost vaccine regimens using heterologous and homologous vector and gene inserts. Heterologous regimens offer a promising approach that focuses the cell-mediated immune response on the insert and away from vector-dominated responses. Ad35-GRIN/ENV (Ad35-GE) vaccine is comprised of two vectors containing sequences from HIV-1 subtype A gag, rt, int, nef (Ad35-GRIN) and env (Ad35-ENV). MVA-CMDR (MVA-C), MVA-KEA (MVA-K) and MVA-TZC (MVA-T) vaccines contain gag, env and pol genes from HIV-1 subtypes CRF01_AE, A and C, respectively. Balb/c mice were immunized with different heterologous and homologous vector and insert prime-boost combinations. HIV and vector-specific immune responses were quantified post-boost vaccination. Gag-specific IFN-gamma ELISPOT, intracellular cytokine staining (ICS) (CD107 alpha, IFN-alpha, TNF-alpha and IL-2), pentamer staining and T-cell phenotyping were used to differentiate responses to inserts and vectors. Ad35-GE prime followed by boost with any of the recombinant MVA constructs (rMVA) induced CD8+ Gag-specific responses superior to Ad35-GE-Ad35-GE or rMVA-rMVA prime-boost combinations. Notably, there was a shift toward insert-focus responses using heterologous vector prime-boost regimens. Gag-specific central and effector memory T cells were generated more rapidly and in greater numbers in the heterologous compared to the homologous prime-boost regimens. These results suggest that heterologous prime-boost vaccination regimens enhance immunity by increasing the magnitude, onset and multifunctionality of the insert-specific cell-mediated immune response compared to homologous vaccination regimens. This study supports the rationale for testing heterologous prime-boost regimens in humans. C1 [Ratto-Kim, Silvia; Currier, Jeffrey R.; Valencia-Micolta, Anais; Thelian, Doris; Lo, Vicky; Polonis, Victoria R.; Robb, Merlin L.; Michael, Nelson L.; Kim, Jerome H.; Marovich, Mary A.] Walter Reed Army Inst Res, US Mil HIV Res Program, Rockville, MD USA. [Cox, Josephine H.; Excler, Jean-Louis; Sayeed, Eddy] Int AIDS Vaccine Initiat, New York, NY USA. [Earl, Patricia L.; Moss, Bernard] NIAID, Viral Dis Lab, NIH, Bethesda, MD 20892 USA. RP Ratto-Kim, S (reprint author), Walter Reed Army Inst Res, US Mil HIV Res Program, Rockville, MD USA. EM sratto-kim@hivresearch.org FU United States Army Medical Research and Materiel Command [Y1-AI-2642-12]; National Institute of Allergy and Infectious Diseases; Henry M. Jackson Foundation for the Advancement of Military Medicine [W81XWH-07-2-6700-P00001]; United States Department of Defense; International AIDS Vaccine Initiative; American people through the United States Agency for International Development (USAID) [GPO-A-00-06-00006-00] FX This work was supported in part by an Interagency Agreement (Y1-AI-2642-12) between the United States Army Medical Research and Materiel Command and the National Institute of Allergy and Infectious Diseases and by a cooperative agreement (W81XWH-07-2-6700-P00001) between the Henry M. Jackson Foundation for the Advancement of Military Medicine and the United States Department of Defense. This study was also partially funded by the International AIDS Vaccine Initiative and its donors, including the generous support of the American people through the United States Agency for International Development (USAID; USAID Cooperative Agreement number GPO-A-00-06-00006-00). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 27 TC 20 Z9 20 U1 0 U2 6 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD SEP 26 PY 2012 VL 7 IS 9 AR e45840 DI 10.1371/journal.pone.0045840 PG 10 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 016KP UT WOS:000309517300058 PM 23049876 ER PT J AU Petrich, C Eicken, H Polashenski, CM Sturm, M Harbeck, JP Perovich, DK Finnegan, DC AF Petrich, Chris Eicken, Hajo Polashenski, Christopher M. Sturm, Matthew Harbeck, Jeremy P. Perovich, Donald K. Finnegan, David C. TI Snow dunes: A controlling factor of melt pond distribution on Arctic sea ice SO JOURNAL OF GEOPHYSICAL RESEARCH-OCEANS LA English DT Article ID ALBEDO; VARIABILITY; EVOLUTION; OCEAN; DEPTH AB The location of snow dunes over the course of the ice-growth season 2007/08 was mapped on level landfast first-year sea ice near Barrow, Alaska. Landfast ice formed in mid-December and exhibited essentially homogeneous snow depths of 4-6 cm in mid-January; by early February distinct snow dunes were observed. Despite additional snowfall and wind redistribution throughout the season, the location of the dunes was fixed by March, and these locations were highly correlated with the distribution of meltwater ponds at the beginning of June. Our observations, including ground-based light detection and ranging system (lidar) measurements, show that melt ponds initially form in the interstices between snow dunes, and that the outline of the melt ponds is controlled by snow depth contours. The resulting preferential surface ablation of ponded ice creates the surface topography that later determines the melt pond evolution. C1 [Petrich, Chris] No Res Inst, NO-8504 Narvik, Norway. [Petrich, Chris; Eicken, Hajo; Harbeck, Jeremy P.] Univ Alaska Fairbanks, Inst Geophys, Fairbanks, AK 99775 USA. [Eicken, Hajo] Univ Alaska Fairbanks, Int Arctic Res Ctr, Fairbanks, AK USA. [Polashenski, Christopher M.; Sturm, Matthew] USA, Cold Reg Res & Engn Lab Alaska, Ft Wainwright, AK USA. [Harbeck, Jeremy P.] NASA, Goddard Space Flight Ctr, Greenbelt, MD 20771 USA. [Perovich, Donald K.; Finnegan, David C.] USA, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. RP Petrich, C (reprint author), No Res Inst, POB 250, NO-8504 Narvik, Norway. EM christian.petrich@norut.no RI Eicken, Hajo/M-6901-2016; OI Petrich, Chris/0000-0003-2226-0789 FU National Science Foundation Office of Polar Programs [OPP-0632398, OPP-0856867]; University of Alaska Foundation; Research Council of Norway [195153] FX Data acquisition for this project was supported by the National Science Foundation Office of Polar Programs (awards OPP-0632398 and OPP-0856867). Chris Petrich would like to acknowledge an International Polar Year postdoctoral fellowship of the University of Alaska Foundation and the Research Council of Norway (project number 195153) that allowed for analysis of the data. Weather data were provided by the National Oceanic and Atmospheric Administration (NOAA). We wish to acknowledge staff at the Barrow Arctic Science Consortium (BASC) for excellent support of this project. Magnaprobe snow depth measurements on 1 May 2008 and some thickness measurements for Figure 6 were performed by volunteers of Ben and Jerry's Climate Change College. We are indebted to Martin Stuefer for providing us with the opportunity to take aerial photographs from his plane. The constructive comments of Ian Eisenman and two anonymous reviewers of an earlier version of this manuscript, and two anonymous reviewers of this manuscript are gratefully acknowledged. NR 33 TC 18 Z9 19 U1 1 U2 23 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA SN 0148-0227 J9 J GEOPHYS RES-OCEANS JI J. Geophys. Res.-Oceans PD SEP 25 PY 2012 VL 117 AR C09029 DI 10.1029/2012JC008192 PG 10 WC Oceanography SC Oceanography GA 015BW UT WOS:000309421000001 ER PT J AU Laflin, KE Morris, CJ Muqeem, T Gracias, DH AF Laflin, Kate E. Morris, Christopher J. Muqeem, Tanziyah Gracias, David H. TI Laser triggered sequential folding of microstructures SO APPLIED PHYSICS LETTERS LA English DT Article ID ROBOTIC SURGERY; MICROACTUATOR; ACTUATORS; DESIGN AB In order to fabricate complex origami inspired devices, it is necessary to control folding pathways and enable sequential folding. We demonstrate sequential folding of microstructures from afar by the directed heating of pre-stressed hinges using low power, 40-80 mW handheld, commercial lasers. We observed that the hinge-actuation and consequently folding time varied with laser irradiance, wavelength, and distance. We highlight possible applications by sequential folding of patterned and nested microstructures. (C) 2012 American Institute of Physics. [http://dx.doi.org/10.1063/1.4754607] C1 [Laflin, Kate E.; Gracias, David H.] Johns Hopkins Univ, Dept Chem & Biomol Engn, Baltimore, MD 21218 USA. [Morris, Christopher J.] USA, Res Lab, Adelphi, MD 20783 USA. [Muqeem, Tanziyah] Johns Hopkins Univ, Dept Biomed Engn, Baltimore, MD 21218 USA. [Gracias, David H.] Johns Hopkins Univ, Dept Chem, Baltimore, MD 21218 USA. RP Gracias, DH (reprint author), Johns Hopkins Univ, Dept Chem & Biomol Engn, Baltimore, MD 21218 USA. EM dgracias@jhu.edu RI Gracias, David/A-1942-2010 OI Gracias, David/0000-0003-2735-4725 FU Northrop Grumman; Johns Hopkins Institute for NanoBiotechnology; U.S. Army Research Laboratory FX This work was supported by Northrop Grumman, the Johns Hopkins Institute for NanoBiotechnology, and the U.S. Army Research Laboratory. NR 34 TC 13 Z9 13 U1 0 U2 32 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD SEP 24 PY 2012 VL 101 IS 13 AR 131901 DI 10.1063/1.4754607 PG 4 WC Physics, Applied SC Physics GA 015DX UT WOS:000309426800022 ER PT J AU Gurton, KP Felton, M AF Gurton, Kristan P. Felton, Melvin TI Remote detection of buried land-mines and IEDs using LWIR polarimetric imaging SO OPTICS EXPRESS LA English DT Article ID ROC ANALYSIS; SENSORS; SYSTEM AB We report results of an ongoing study designed to assess the ability for enhanced detection of recently buried land-mines and/or improvised explosive devices (IED) devices using passive long-wave infrared (LWIR) polarimetric imaging. Polarimetric results are presented for a series of field tests conducted at various locations and soil types. Well-calibrated Stokes images, S0, S1, S2, and the degree-of-linear-polarization (DoLP) are recorded for different line-of-sight (LOS) slant paths at varying distances. Results span a three-year time period in which three different LWIR polarimetric camera systems are used. All three polarimetric imaging platforms used a spinning-achromatic-retarder (SAR) design capable of achieving high polarimetric frame rates and good radiometric throughput without the loss of spatial resolution inherent in other optical designs. Receiver-operating-characteristic (ROC) analysis and a standardized contrast parameter are used to compare detectability between conventional LWIR thermal and polarimetric imagery. Results suggest improved detectability, regardless of geographic location or soil type. (C) 2012 Optical Society of America C1 [Gurton, Kristan P.; Felton, Melvin] USA, Res Lab, Adelphi, MD 20783 USA. RP Gurton, KP (reprint author), USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM kristan.p.gurton.civ@mail.mil NR 31 TC 5 Z9 6 U1 1 U2 24 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1094-4087 J9 OPT EXPRESS JI Opt. Express PD SEP 24 PY 2012 VL 20 IS 20 BP 22344 EP 22359 DI 10.1364/OE.20.022344 PG 16 WC Optics SC Optics GA 016MJ UT WOS:000309522400051 PM 23037383 ER PT J AU Shakarian, P Wickiser, JK AF Shakarian, Paulo Wickiser, J. Kenneth TI Similar Pathogen Targets in Arabidopsis thaliana and Homo sapiens Protein Networks SO PLOS ONE LA English DT Article ID TRANSMISSION; CENTRALITY; VIRULENCE AB We study the behavior of pathogens on host protein networks for humans and Arabidopsis - noting striking similarities. Specifically, we preform k-shell decomposition analysis on these networks - which groups the proteins into various "shells" based on network structure. We observe that shells with a higher average degree are more highly targeted (with a power-law relationship) and that highly targeted nodes lie in shells closer to the inner-core of the network. Additionally, we also note that the inner core of the network is significantly under-targeted. We show that these core proteins may have a role in intra-cellular communication and hypothesize that they are less attacked to ensure survival of the host. This may explain why certain high-degree proteins are not significantly attacked. C1 [Shakarian, Paulo] United States Mil Acad, Paulo Shakarian Dept Elect Engn & Comp Sci, West Point, NY USA. [Wickiser, J. Kenneth] United States Mil Acad, J Kenneth Wickiser Dept Life Sci, West Point, NY USA. RP Shakarian, P (reprint author), United States Mil Acad, Paulo Shakarian Dept Elect Engn & Comp Sci, West Point, NY USA. EM paulo@shakarian.net FU ARO [611102B74F] FX P.S. and J.K.W. are supported by ARO grant 611102B74F, the opinions in this paper are those of the authors and do not necessarily reflect the opinions of the funders, the U. S. Military Academy, or the U. S. Army. http://www.arl.army.mil/www/default.cfm?page = 29 The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 17 TC 0 Z9 0 U1 0 U2 6 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD SEP 21 PY 2012 VL 7 IS 9 AR e45154 DI 10.1371/journal.pone.0045154 PG 7 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 014RG UT WOS:000309392800029 PM 23049774 ER PT J AU Lang, ET Brown-Peterson, NJ Peterson, MS Slack, WT AF Lang, Erik T. Brown-Peterson, Nancy J. Peterson, Mark S. Slack, William T. TI Seasonal and Tidally Driven Reproductive Patterns in the Saltmarsh Topminnow, Fundulus jenkinsi SO COPEIA LA English DT Article ID SEMILUNAR SPAWNING CYCLES; GULF KILLIFISH; LIFE-HISTORY; SPOTFIN KILLIFISH; HETEROCLITUS; GRANDIS; ECOLOGY; HABITAT; FISHES; CYPRINODONTIDAE AB Fundulus jenkinsi is recognized federally and within a number of northern Gulf of Mexico states as a Species of Concern. Little is known about its life history, but a detailed reproductive histology study of F. jenkinsi can provide the foundation needed to quantify reproductive parameters in this rare species in need of conservation. Monthly gonadosomatic index (GSI) of male and female F. jenkinsi indicated a spawning season from April through August. However, ovarian histological analysis suggested March through August was a more accurate spawning season. The multiple oocyte stages within F. jenkinsi in the spawning capable reproductive phase indicates batch spawning, similar to other members of its family. Many estuarine members of the family Fundulidae exhibit a semilunar spawning pattern, yet the oocyte composition of ovaries of F. jenkinsi suggested spawns occur multiple days around the time of spring tides both within a population and on the individual level. Spawning did not occur on neap tides, and no late secondary growth vitellogenic oocytes (SGI) were found in the majority of females captured during neap tide. The lack of SGI oocytes in females during the spawning season suggests the necessity for establishing a new sub-phase within the spawning capable phase, termed the redeveloping sub-phase. This new sub-phase is applicable to other batch spawning species with group synchronous oocyte development. This work contributes to a better understanding of the importance of intertidal saltmarsh habitat to F. jenkinsi, as spawning intensity appears to increase with tidal height and marsh inundation. C1 [Lang, Erik T.; Brown-Peterson, Nancy J.; Peterson, Mark S.] Univ So Mississippi, Dept Coastal Sci, Ocean Springs, MS USA. [Slack, William T.] USA, Engineer Res & Dev Ctr, Waterways Expt Stn EE A, Vicksburg, MS 39180 USA. RP Lang, ET (reprint author), NOAA, 3500 Delwood Beach Rd, Panama City, FL 32408 USA. EM erik.lang@noaa.gov; nancy.brown-peterson@usm.edu; mark.peterson@usm.edu; todd.slack@usace.army.mil FU USFWS; Mississippi Museum of Natural Science under the Mississippi Department of Wildlife Fisheries and Parks FX We thank the USFWS in conjunction with the Mississippi Museum of Natural Science under the Mississippi Department of Wildlife Fisheries and Parks for funding this project. We also thank J. Lopez, P. Grammer, M. Lowe, J. Havrylkoff, and M. Andres for field assistance, and G. Grammer for images in Fig. 1. This research was conducted with a blanket sampling permit to the USM-Gulf Coast Research Laboratory and was approved and performed under the USM IACUC protocol #10040802. NR 40 TC 4 Z9 4 U1 0 U2 10 PU AMER SOC ICHTHYOLOGISTS & HERPETOLOGISTS PI MIAMI PA MAUREEN DONNELLY, SECRETARY FLORIDA INT UNIV BIOLOGICAL SCIENCES, 11200 SW 8TH STREET, MIAMI, FL 33199 USA SN 0045-8511 EI 1938-5110 J9 COPEIA JI Copeia PD SEP 20 PY 2012 IS 3 BP 451 EP 459 DI 10.1643/CP-10-187 PG 9 WC Zoology SC Zoology GA 014MD UT WOS:000309379000011 ER PT J AU Scott, AM Gorb, L Mobley, EA Hill, FC Leszczynski, J AF Scott, A. M. Gorb, L. Mobley, E. A. Hill, F. C. Leszczynski, J. TI Predictions of Gibbs Free Energies for the Adsorption of Polyaromatic and Nitroaromatic Environmental Contaminants on Carbonaceous Materials: Efficient Computational Approach SO LANGMUIR LA English DT Article ID POLYCYCLIC AROMATIC-HYDROCARBONS; SPACE GAUSSIAN PSEUDOPOTENTIALS; APPROXIMATE COULOMB POTENTIALS; DENSITY-FUNCTIONAL THEORY; AUXILIARY BASIS-SETS; DER-WAALS COMPLEXES; PI-PI INTERACTIONS; AB-INITIO; BENZENE DIMER; ACTIVATED CARBON AB The adsorption of benzene, polycyclic aromatic hydrocarbons (PAHs), and nitroaromatic compounds (NACs) on the carbonaceous surfaces from the gas phase and water solution was investigated. Several different levels of theory were applied, including DFT-, MP2-, and CCSD(T)-based methods, to find an approach that is computationally inexpensive and can provide accurate thermodynamic parameters for studied adsorption phenomena. The methods and techniques used (including cluster and periodic approximations) were evaluated on the basis of comparison with available experimental data. The optimized structures of calculated complexes are obtained, and the interaction energies and Gibbs free energies are predicted. Good agreement was revealed for the theoretical and experimental adsorption energies of benzene and PAHs adsorbed on the carbon surfaces. The adsorption of benzene, PAHs, and NACs on carbon is suggested to be effective from the gas phase for all studied compounds and for PAHs and NACs also from water solution at room temperature. C1 [Gorb, L.; Mobley, E. A.] Badger Tech Serv LLC, Vicksburg, MS 39180 USA. [Scott, A. M.; Hill, F. C.; Leszczynski, J.] USA, ERDC, Vicksburg, MS 39180 USA. [Leszczynski, J.] Jackson State Univ, Interdisciplinary Nanotox Ctr, Dept Chem & Biochem, Jackson, MS 39217 USA. RP Gorb, L (reprint author), Badger Tech Serv LLC, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM lgorb@icnanotox.org FU High Performance Computing Major Shared Resource Center at the ERDC (Vicksburg, MS); Office of Naval Research [N00034-03-1-0116]; Environmental Quality Technology Program of the United States Army Corps of Engineers by the U.S. Army ERDC FX We acknowledge Dr. Roman Zhurakivsky for his help with the CCSD(T) calculations. This work was facilitated by support from the High Performance Computing Major Shared Resource Center at the ERDC (Vicksburg, MS) and the Office of Naval Research (grant No. N00034-03-1-0116). The use of trade, product, or firm names in this report is for descriptive purposes only and does not imply endorsement by the U.S. Government. Results in this study were funded and obtained from research conducted under the Environmental Quality Technology Program of the United States Army Corps of Engineers by the U.S. Army ERDC. Permission was granted by the Chief of Engineers to publish this information. The findings of this report are not to be construed as an official Department of the Army position unless so designated by other authorized documents. NR 92 TC 7 Z9 7 U1 0 U2 27 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0743-7463 J9 LANGMUIR JI Langmuir PD SEP 18 PY 2012 VL 28 IS 37 BP 13307 EP 13317 DI 10.1021/la3027286 PG 11 WC Chemistry, Multidisciplinary; Chemistry, Physical; Materials Science, Multidisciplinary SC Chemistry; Materials Science GA 005ZC UT WOS:000308787700022 PM 22909085 ER PT J AU Ravichandran, S Nagarajan, S Kokil, A Ponrathnam, T Bouldin, RM Bruno, FF Samuelson, L Kumar, J Nagarajan, R AF Ravichandran, Sethumadhavan Nagarajan, Subhalakshmi Kokil, Akshay Ponrathnam, Timothy Bouldin, Ryan M. Bruno, Ferdinando F. Samuelson, Lynne Kumar, Jayant Nagarajan, Ramaswamy TI Micellar Nanoreactors for Hematin Catalyzed Synthesis of Electrically Conducting Polypyrrole SO LANGMUIR LA English DT Article ID HEME-CONTAINING OXYGENASES; ENZYMATIC-SYNTHESIS; STRUCTURAL-PROPERTIES; SOLUBLE POLYPYRROLE; SOYBEAN PEROXIDASE; POLYMERS; POLYMERIZATION; POLYANILINE; TEMPERATURE; PYRROLE AB Enzymatic synthesis of doped polypyrrole (PPy) complexes using oxidoreductases (specifically peroxidases) is very well established "green" methods for producing conducting polypyrrole. The importance of this approach is realized by the numerous potential opportunities of using PPy in biological applications. However, due to very high costs and low acid stability of these enzymes, there is need for more robust alternate biomimetic catalysts. Hematin, a hydroxyferriprotoporphyrin, has a similar iron catalytic active center like the peroxidases and has previously shown to catalyze polymerization of phenol monomers at pH 12. The insolubility of hematin due to extensive self-aggregation at low pH conditions has prevented its use in the synthesis of conjugated polymers. In this study, we have demonstrated the use of a micellar environment with sodium dodecylbenzenesulfonate (DBSA) for biomimetic synthesis of PPy. The micellar environment helps solubilize hematin, generating nanometer size reactors for the polymerization of pyrrole. The resulting PPy is characterized using UV-visible, Fourier transform infrared, and X-ray photoelectron spectroscopy and reveals the formation of an ordered PPy/DBSA complex with conductivities approaching 0.1 S/cm. C1 [Ravichandran, Sethumadhavan; Nagarajan, Subhalakshmi] Univ Massachusetts, Dept Chem, Lowell, MA 01854 USA. [Kokil, Akshay; Kumar, Jayant] Univ Massachusetts, Dept Phys & Appl Phys, Lowell, MA 01854 USA. [Ponrathnam, Timothy; Nagarajan, Ramaswamy] Univ Massachusetts, Dept Plast Engn, Lowell, MA 01854 USA. [Bouldin, Ryan M.] Univ Massachusetts, Dept Chem Engn, Lowell, MA 01854 USA. [Bruno, Ferdinando F.; Samuelson, Lynne] USA, Natick Soldier Res Dev & Engn Ctr, Natick, MA 01760 USA. RP Nagarajan, R (reprint author), Ball 209A,1 Univ Ave, Lowell, MA 01854 USA. RI Kokil, Akshay/A-6886-2009 OI Kokil, Akshay/0000-0002-8295-2878 FU University of Massachusetts Lowell FX The authors would like acknowledge Dr. Daniel Sandman for his insightful suggestions on the effective use of biomimetic catalysts. Dr. Earl Ada of the center for high rate nano-manufacturing is gratefully acknowledged for his help with TEM imaging. Financial support from University of Massachusetts Lowell new faculty start-up fund is also gratefully acknowledged. NR 37 TC 16 Z9 17 U1 4 U2 44 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0743-7463 J9 LANGMUIR JI Langmuir PD SEP 18 PY 2012 VL 28 IS 37 BP 13380 EP 13386 DI 10.1021/la302494a PG 7 WC Chemistry, Multidisciplinary; Chemistry, Physical; Materials Science, Multidisciplinary SC Chemistry; Materials Science GA 005ZC UT WOS:000308787700031 PM 22906396 ER PT J AU Kong, D Le, LT Li, Y Zunino, JL Lee, W AF Kong, De Le, Linh T. Li, Yue Zunino, James L. Lee, Woo TI Temperature-Dependent Electrical Properties of Graphene Inkjet-Printed on Flexible Materials SO LANGMUIR LA English DT Article ID OXIDE; TRANSPARENT; ELECTRONICS; REDUCTION; FILMS AB Graphene electrode was fabricated by inkjet printing, as a new means of directly writing and micropatterning the electrode onto flexible polymeric materials. Graphene oxide sheets were dispersed in water and subsequently reduced using an infrared heat lamp at a temperature of similar to 200 degrees C in 10 min. Spacing between adjacent ink droplets and the number of printing layers were used to tailor the electrode's electrical sheet resistance as low as 0.3 M Omega/square and optical transparency as high as 86%. The graphene electrode was found to be stable under mechanical flexing and behave as a negative temperature coefficient (NTC) material, exhibiting rapid electrical resistance decrease with temperature increase. Temperature sensitivity of the graphene electrode was similar to that of conventional NTC materials, but with faster response time by an order of magnitude. This finding suggests the potential use of the inkjet-printed graphene electrode as a writable, very thin, mechanically flexible, and transparent temperature sensor. C1 [Kong, De; Le, Linh T.; Li, Yue; Lee, Woo] Stevens Inst Technol, Dept Chem Engn & Mat Sci, Hoboken, NJ 07030 USA. [Zunino, James L.] USA, ARDEC, Picatinny Arsenal, NJ 07806 USA. RP Lee, W (reprint author), Stevens Inst Technol, Dept Chem Engn & Mat Sci, Hoboken, NJ 07030 USA. EM wlee@stevens.edu FU U.S. Army - ARDEC [W15QKN-05-D-0011]; National Science Foundation [DMR-0922522] FX The authors thank the U.S. Army - ARDEC for funding this project under the contract of W15QKN-05-D-0011. This research effort used microscope resources partially funded by the National Science Foundation through NSF Grant DMR-0922522. We also thank Andrew Ihnen at Stevens and Brian Fuchs at ARDEC for various discussions. NR 21 TC 47 Z9 48 U1 8 U2 138 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0743-7463 J9 LANGMUIR JI Langmuir PD SEP 18 PY 2012 VL 28 IS 37 BP 13467 EP 13472 DI 10.1021/la301775d PG 6 WC Chemistry, Multidisciplinary; Chemistry, Physical; Materials Science, Multidisciplinary SC Chemistry; Materials Science GA 005ZC UT WOS:000308787700041 PM 22924965 ER PT J AU Aygun, A Buthker, JW Stephenson, LD Kumar, A Mahle, TK Gewirth, AA AF Aygun, Aysegul Buthker, Joseph W. Stephenson, Larry D. Kumar, Ashok Mahle, Thomas K. Gewirth, Andrew A. TI Electrochemically controlled swelling properties of nanoporous templated polypyrrole and layer by layer polypyrrole SO JOURNAL OF ELECTROANALYTICAL CHEMISTRY LA English DT Article DE Polypyrrole; EQCM; Conducting polymers; Layer-by-layer; Nanoporous ID QUARTZ-CRYSTAL MICROBALANCE; BENDING BEAM METHOD; CONDUCTING POLYMERS; POLYELECTROLYTE MULTILAYERS; CONFORMATIONAL RELAXATION; ELECTROACTIVE POLYMERS; PROPYLENE CARBONATE; VOLUME CHANGES; FILMS; ELECTROLYTES AB Electrochemically controlled swelling properties of polypyrrole (PPy) are investigated by comparing the performance of layer-by-layer (LbL) assembled and nanoporous templated (NT) systems. The swelling behavior was improved for the NT and LbL systems over that of unmodified PPy. Reversible swelling of about 20% in 120s on the first cycle was measured with the NT PPy via the electrochemical quartz crystal microbalance (EQCM). The changes in the morphology and roughness that occur with swelling and shrinking were measured using in situ electrochemical atomic force microscopy (EC-AFM). Electrochemical impedance spectroscopy (EIS) measurements showed that both the LbL and NT systems exhibited increased surface area relative to unmodified PPy thin films. The understanding of the changes occurring due to molecular and nanostructural reconfiguration in response to electrochemical stimuli may lead to potential applications in the development of a new generation of smart materials, in particular, more effective switchable materials. (C) 2012 Elsevier B.V. All rights reserved. C1 [Aygun, Aysegul; Stephenson, Larry D.; Kumar, Ashok] USA, Construct Engn Res Lab, Corps Engineers, Champaign, IL 61822 USA. [Aygun, Aysegul] Pertan Grp, Champaign, IL 61820 USA. [Buthker, Joseph W.; Mahle, Thomas K.; Gewirth, Andrew A.] Univ Illinois, Dept Chem, Urbana, IL 61801 USA. RP Aygun, A (reprint author), USA, Construct Engn Res Lab, Corps Engineers, Champaign, IL 61822 USA. EM aysegul.aygun@usace.army.mil FU USACE 6.1 funds FX This work was funded by USACE 6.1 funds. NR 42 TC 8 Z9 8 U1 4 U2 43 PU ELSEVIER SCIENCE SA PI LAUSANNE PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND SN 1572-6657 J9 J ELECTROANAL CHEM JI J. Electroanal. Chem. PD SEP 15 PY 2012 VL 684 BP 47 EP 52 DI 10.1016/j.jelechem.2012.08.034 PG 6 WC Chemistry, Analytical; Electrochemistry SC Chemistry; Electrochemistry GA 036DD UT WOS:000311005700007 ER PT J AU Saguil, A Phelps, K AF Saguil, Aaron Phelps, Karen TI The Spiritual Assessment SO AMERICAN FAMILY PHYSICIAN LA English DT Article ID CORONARY-CARE UNIT; RELIGIOUS ATTENDANCE; INTERCESSORY PRAYER; FAMILY PHYSICIANS; MEDICAL-PRACTICE; OLDER-ADULTS; ATTITUDES; BELIEFS; SURVIVAL; HEALTH AB More than 80 percent of Americans perceive religion as important. Issues of belief can affect the health care encounter, and patients may wish to discuss spirituality with their physician. Many physicians report barriers to broaching the subject of spirituality, including lack of time and experience, difficulty identifying patients who want to discuss spirituality, and the belief that addressing spiritual concerns is not a physician's responsibility. Spiritual assessment tools such as the FICA, the HOPE questions, and the Open Invite provide efficient means of eliciting patients' thoughts on this topic. The spiritual assessment allows physicians to support patients by stressing empathetic listening, documenting spiritual preferences for future visits, incorporating the precepts of patients' faith traditions into treatment plans, and encouraging patients to use the resources of their spiritual traditions and communities for overall wellness. Conducting the spiritual assessment also may help strengthen the physician-patient relationship and offer physicians opportunities for personal renewal, resiliency, and growth. (Am Fam Physician. 2012;86(6):546-550. Copyright (C) 2012 American Academy of Family Physicians.) C1 [Saguil, Aaron] Ft Belvoir Community Hosp, Ft Belvoir, VA 22060 USA. [Phelps, Karen] Eisenhower Army Med Ctr, Ft Gordon, GA USA. RP Saguil, A (reprint author), Ft Belvoir Community Hosp, 9300 DeWitt Loop, Ft Belvoir, VA 22060 USA. EM aaron.saguil@us.army.mil NR 32 TC 12 Z9 12 U1 0 U2 8 PU AMER ACAD FAMILY PHYSICIANS PI KANSAS CITY PA 8880 WARD PARKWAY, KANSAS CITY, MO 64114-2797 USA SN 0002-838X J9 AM FAM PHYSICIAN JI Am. Fam. Physician PD SEP 15 PY 2012 VL 86 IS 6 BP 546 EP 550 PG 5 WC Primary Health Care; Medicine, General & Internal SC General & Internal Medicine GA 006WF UT WOS:000308849600009 PM 23062046 ER PT J AU Newburgh, GA Fleischman, Z Dubinskii, M AF Newburgh, G. A. Fleischman, Z. Dubinskii, M. TI Highly efficient dual-wavelength laser operation of cryo-cooled resonantly (in-band) pumped Ho3+:YVO4 laser SO OPTICS LETTERS LA English DT Article AB We have demonstrated a CW, multiwatt, dual-wavelength cryogenically cooled, resonantly (in-band) pumped Ho3+:YVO4 laser with nearly quantum-defect-limited performance. The Ho3+(2%):YVO4 gain element, which was maintained at similar to 80 K and pumped by a Tm-fiber laser at 1966 nm, emitted at wavelengths of either 2053 or 2068 nm, or both at the same time, depending on the outcoupling loss and the pump power. We have achieved laser operation with a maximum slope efficiency of similar to 92%. This is, to the best of our knowledge, the highest slope efficiency ever demonstrated for any Ho3+-doped laser. (C) 2012 Optical Society of America C1 [Newburgh, G. A.; Fleischman, Z.; Dubinskii, M.] USA, Res Lab, Attn RDRL SEE M, Adelphi, MD 20783 USA. RP Newburgh, GA (reprint author), USA, Res Lab, Attn RDRL SEE M, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM george.a.newburgh.civ@mail.mil FU High Energy Laser Joint Technology Office FX This work has been partially supported by the High Energy Laser Joint Technology Office. NR 9 TC 5 Z9 5 U1 0 U2 16 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 0146-9592 J9 OPT LETT JI Opt. Lett. PD SEP 15 PY 2012 VL 37 IS 18 BP 3888 EP 3890 PG 3 WC Optics SC Optics GA 009SU UT WOS:000309046300050 PM 23041893 ER PT J AU Clayton, JD Kraft, RH Leavy, RB AF Clayton, J. D. Kraft, R. H. Leavy, R. B. TI Mesoscale modeling of nonlinear elasticity and fracture in ceramic polycrystals under dynamic shear and compression SO INTERNATIONAL JOURNAL OF SOLIDS AND STRUCTURES LA English DT Article DE Elasticity; Fracture; Finite elements; Ceramics; Polycrystals ID GRAIN-BOUNDARY PROPERTIES; HIGH-DENSITY POLYCRYSTALS; PRESSED SILICON-CARBIDE; SHOCK-WAVE COMPRESSION; BRITTLE MATERIALS; FAILURE INITIATION; FLEXURAL STRENGTH; LEVEL MODEL; DEFORMATION; PENETRATION AB Dynamic deformation and failure mechanisms in polycrystalline ceramics are investigated through constitutive modeling and numerical simulation. Two ceramics are studied: silicon carbide (SiC, hexagonal crystal structure) and aluminum oxynitride (AlON, cubic crystal structure). Three dimensional finite element simulations incorporate nonlinear anisotropic elasticity for behavior of single crystals within polycrystalline aggregates, cohesive zone models for intergranular fracture, and contact interactions among fractured interfaces. Boundary conditions considered include uniaxial strain compression, uniaxial stress compression, and shear with varying confinement, all at high loading rates. Results for both materials demonstrate shear-induced dilatation and increasing shear strength with increasing confining pressure. Failure statistics for unconfined loading exhibit a smaller Weibull modulus (corresponding to greater scatter in peak failure strength) in AlON than in SiC, likely a result of lower prescribed cohesive fracture strength and greater elastic anisotropy in the former. In both materials, the predicted Weibull modulus tends to decrease with an increasing number of grains contained in the simulated microstructure. Published by Elsevier Ltd. C1 [Clayton, J. D.; Kraft, R. H.; Leavy, R. B.] USA, RDRL WMP B, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Clayton, JD (reprint author), USA, RDRL WMP B, Res Lab, Aberdeen Proving Ground, MD 21005 USA. EM john.d.clayton1@us.army.mil RI Clayton, John/C-7760-2009 NR 76 TC 11 Z9 12 U1 1 U2 29 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0020-7683 J9 INT J SOLIDS STRUCT JI Int. J. Solids Struct. PD SEP 15 PY 2012 VL 49 IS 18 BP 2686 EP 2702 DI 10.1016/j.ijsolstr.2012.05.035 PG 17 WC Mechanics SC Mechanics GA 987KU UT WOS:000307416600028 ER PT J AU Gautam, A Dixit, S Embers, M Gautam, R Philipp, MT Singh, SR Morici, L Dennis, VA AF Gautam, Aarti Dixit, Saurabh Embers, Monica Gautam, Rajeev Philipp, Mario T. Singh, Shree R. Morici, Lisa Dennis, Vida A. TI Different Patterns of Expression and of IL-10 Modulation of Inflammatory Mediators from Macrophages of Lyme Disease-Resistant and -Susceptible Mice SO PLOS ONE LA English DT Article ID BORRELIA-BURGDORFERI LIPOPROTEINS; COLLAGEN-INDUCED ARTHRITIS; HUMAN MONOCYTIC CELLS; TOLL-LIKE RECEPTOR-2; HOST-DEFENSE; IFN-GAMMA; INTERLEUKIN-10 PRODUCTION; TREPONEMA-PALLIDUM; ERYTHEMA MIGRANS; MESSENGER-RNA AB C57BL/6J (C57) mice develop mild arthritis (Lyme disease-resistant) whereas C3H/HeN (C3H) mice develop severe arthritis (Lyme disease-susceptible) after infection with the spirochete Borrelia burgdorferi. We hypothesized that susceptibility and resistance to Lyme disease, as modeled in mice, is associated with early induction and regulation of inflammatory mediators by innate immune cells after their exposure to live B. burgdorferi spirochetes. Here, we employed multiplex ELISA and qRT-PCR to investigate quantitative differences in the levels of cytokines and chemokines produced by bone marrow-derived macrophages from C57 and C3H mice after these cells were exposed ex vivo to live spirochetes or spirochetal lipoprotein. Upon stimulation, the production of both cytokines and chemokines was up-regulated in macrophages from both mouse strains. Interestingly, however, our results uncovered two distinct patterns of spirochete- and lipoprotein-inducible inflammatory mediators displayed by mouse macrophages, such that the magnitude of the chemokine up-regulation was larger in C57 cells than it was in C3H cells, for most chemokines. Conversely, cytokine up-regulation was more intense in C3H cells. Gene transcript analyses showed that the displayed patterns of inflammatory mediators were associated with a TLR2/TLR1 transcript imbalance: C3H macrophages expressed higher TLR2 transcript levels as compared to those expressed by C57 macrophages. Exogenous IL-10 dampened production of inflammatory mediators, especially those elicited by lipoprotein stimulation. Neutralization of endogenously produced IL-10 increased production of inflammatory mediators, notably by macrophages of C57 mice, which also displayed more IL-10 than C3H macrophages. The distinct patterns of proinflammatory mediator production, along with TLR2/TLR1 expression, and regulation in macrophages from Lyme disease-resistant and -susceptible mice suggests itself as a blueprint to further investigate differential pathogenesis of Lyme disease. C1 [Gautam, Aarti; Dixit, Saurabh; Embers, Monica; Philipp, Mario T.; Dennis, Vida A.] Tulane Univ, Hlth Sci Ctr, Div Bacteriol & Parasitol, Tulane Natl Primate Res Ctr, Covington, LA USA. [Gautam, Rajeev] Tulane Univ, Hlth Sci Ctr, Div Microbiol, Tulane Natl Primate Res Ctr, Covington, LA USA. [Dixit, Saurabh; Singh, Shree R.; Dennis, Vida A.] Alabama State Univ, Ctr Nanobiotechnol Res, Montgomery, AL 36101 USA. [Morici, Lisa] Tulane Univ, Hlth Sci Ctr, Dept Microbiol & Immunol, New Orleans, LA 70118 USA. RP Gautam, A (reprint author), USA, Integrat Syst Biol Program, Ctr Environm Hlth Res, Ft Detrick, MD USA. EM vdennis@alasu.edu FU National Institute of Allergy and Infectious Diseases [R21AI073356]; National Center for Research Resources, National Institutes of Health [RR00164]; National Science Foundation-Centers of Research Excellence in Science and Technology [HRD- 0734232] FX The project described was supported by Grant Number R21AI073356 from the National Institute of Allergy and Infectious Diseases; Grant Number RR00164 from the National Center for Research Resources, National Institutes of Health and Grant Number HRD- 0734232 from National Science Foundation-Centers of Research Excellence in Science and Technology. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institute of Allergy and Infectious Diseases or the National Institutes of Health. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 85 TC 11 Z9 12 U1 1 U2 10 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD SEP 14 PY 2012 VL 7 IS 9 AR e43860 DI 10.1371/journal.pone.0043860 PG 13 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 007AD UT WOS:000308860100003 PM 23024745 ER PT J AU He, YP Brown, C Lundgren, CA Zhao, YP AF He, Yuping Brown, Cameron Lundgren, Cynthia A. Zhao, Yiping TI The growth of CuSi composite nanorod arrays by oblique angle co-deposition, and their structural, electrical and optical properties SO NANOTECHNOLOGY LA English DT Article ID THIN-FILMS; HYDROGEN STORAGE; NANOCOMPOSITES; DEPOSITION; NANOPARTICLES; BATTERIES; SILICON; ANODES; AG AB Different CuSi composite nanorods with 0-100 at.% Cu were fabricated by an oblique angle co-deposition technique. The effects of increasing Cu during deposition on the morphologies, structures and properties were investigated. During co-evaporation, the addition of Cu decreases the nanorod width and height but increases the nanorod tilting angle. The polarized optical transmission spectra reveal that all the nanorod samples show a remarkable anisotropic response to visible light with an eccentricity e approximate to 1, whereas their optical response to NIR light depends strongly on the Cu composition, and the related eccentricity increases monotonically with the increase of Cu. The obtained amorphous Si film has a resistivity of approximately 4: 9 x 10(4) Omega cm. The incorporation of 5-75 at.% Cu increases the electrical conductance from two to eight orders of magnitude. The improved conductance and the unique optical properties of the Si-based nanocomposites could have potential applications for Li-ion battery anode and optical design. C1 [He, Yuping; Brown, Cameron; Zhao, Yiping] Univ Georgia, Dept Phys & Astron, Athens, GA 30602 USA. [He, Yuping; Brown, Cameron; Zhao, Yiping] Univ Georgia, Nanoscale Sci & Engn Ctr, Athens, GA 30602 USA. [Lundgren, Cynthia A.] USA, Res Lab, Adelphi, MD 20783 USA. RP He, YP (reprint author), Univ Georgia, Dept Phys & Astron, Athens, GA 30602 USA. EM yphe@physast.uga.edu RI He, Yuping/F-2831-2011; Zhao, Yiping/A-4968-2008; Brown, Cameron/H-9563-2014 OI Brown, Cameron/0000-0002-9616-2084 FU US Army Research Laboratory [W911NF-10-2-0107] FX This work was supported by the US Army Research Laboratory with the contract number of W911NF-10-2-0107. NR 41 TC 7 Z9 7 U1 2 U2 37 PU IOP PUBLISHING LTD PI BRISTOL PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND SN 0957-4484 J9 NANOTECHNOLOGY JI Nanotechnology PD SEP 14 PY 2012 VL 23 IS 36 AR 365703 DI 10.1088/0957-4484/23/36/365703 PG 10 WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied SC Science & Technology - Other Topics; Materials Science; Physics GA 992XD UT WOS:000307812800012 PM 22910328 ER PT J AU Bonsignori, M Pollara, J Moody, MA Kepler, TB Chen, X Gurley, TC Kozink, DM Marshall, DJ Whitesides, JF Kaewkungwal, J Nitayaphan, S Pitisuttithum, P Rerks-Ngarm, S Kim, JH Michael, NL Montefiori, DC Liao, H Ferrari, G Haynes, BF AF Bonsignori, M. Pollara, J. Moody, M. A. Kepler, T. B. Chen, X. Gurley, T. C. Kozink, D. M. Marshall, D. J. Whitesides, J. F. Kaewkungwal, J. Nitayaphan, S. Pitisuttithum, P. Rerks-Ngarm, S. Kim, J. H. Michael, N. L. Montefiori, D. C. Liao, H. Ferrari, G. Haynes, B. F. TI Antibody-dependent cellular cytotoxicity-mediating antibodies from an HIV-1 vaccine efficacy trial preferentially use the VH1 gene family SO RETROVIROLOGY LA English DT Meeting Abstract C1 [Bonsignori, M.; Pollara, J.; Moody, M. A.; Chen, X.; Gurley, T. C.; Kozink, D. M.; Marshall, D. J.; Whitesides, J. F.; Montefiori, D. C.; Liao, H.; Ferrari, G.; Haynes, B. F.] Duke Univ, Med Ctr, Durham, NC USA. [Kepler, T. B.] Boston Univ, Sch Med, Boston, MA 02118 USA. [Kaewkungwal, J.; Pitisuttithum, P.] Mahidol Univ, Bangkok 10700, Thailand. [Nitayaphan, S.] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Rerks-Ngarm, S.] Minist Publ Hlth, Dept Dis Control, Nonthaburi, Thailand. [Kim, J. H.; Michael, N. L.] US Mil HIV Res Program, Rockville, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1742-4690 J9 RETROVIROLOGY JI Retrovirology PD SEP 13 PY 2012 VL 9 SU 2 AR P78 DI 10.1186/1742-4690-9-S2-P78 PG 1 WC Virology SC Virology GA 015UO UT WOS:000309472100151 ER PT J AU Franchini, G Pegu, P Gordon, S Keele, B Doster, M Guan, Y Ferrari, G Pal, R Ferrari, MG Whitney, S Hudacik, L Billings, E Rao, M Montefiori, D Venzon, D Fenizia, C Lifson, J Stablein, D Tartaglia, J Michael, N Kim, J AF Franchini, G. Pegu, P. Gordon, S. Keele, B. Doster, M. Guan, Y. Ferrari, G. Pal, R. Ferrari, M. G. Whitney, S. Hudacik, L. Billings, E. Rao, M. Montefiori, D. Venzon, D. Fenizia, C. Lifson, J. Stablein, D. Tartaglia, J. Michael, N. Kim, J. TI Antibodies to the envelope protein protect macaques from SIVmac251 acquisition in an immunization regimen that mimics the RV-144 Thai trial SO RETROVIROLOGY LA English DT Meeting Abstract C1 [Franchini, G.; Pegu, P.; Gordon, S.; Doster, M.; Venzon, D.; Fenizia, C.] NCI, NIH, Bethesda, MD 20892 USA. [Keele, B.; Lifson, J.; Stablein, D.] NCI Frederick, Frederick, MD USA. [Guan, Y.] Univ Maryland, Sch Med, Inst Human Virol, Baltimore, MD 21201 USA. [Pal, R.; Ferrari, M. G.; Whitney, S.; Hudacik, L.] Adv Biosci Labs, Rockville, MD USA. [Billings, E.; Rao, M.] USA, Inst Res, Silver Spring, MD USA. [Montefiori, D.] Duke Univ, Med Ctr, Durham, NC USA. [Tartaglia, J.] Sanofi Pasteur Inc, Swifter, PA USA. [Michael, N.; Kim, J.] Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1742-4690 J9 RETROVIROLOGY JI Retrovirology PD SEP 13 PY 2012 VL 9 SU 2 AR O2 DI 10.1186/1742-4690-9-S2-O2 PG 1 WC Virology SC Virology GA 015UO UT WOS:000309472100003 ER PT J AU Gao, G Peachman, KK Wieczorek, L Polonis, V Alving, CR Rao, M Rao, VB AF Gao, G. Peachman, K. K. Wieczorek, L. Polonis, V. Alving, C. R. Rao, M. Rao, V. B. TI Soluble and bacteriophage T4 displayed gp41 mutant proteins as HIV-1 vaccine candidates SO RETROVIROLOGY LA English DT Meeting Abstract C1 [Gao, G.; Rao, V. B.] Catholic Univ Amer, Washington, DC 20064 USA. [Peachman, K. K.; Wieczorek, L.; Polonis, V.; Alving, C. R.; Rao, M.] USMHRP, Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1742-4690 J9 RETROVIROLOGY JI Retrovirology PD SEP 13 PY 2012 VL 9 SU 2 AR P10 DI 10.1186/1742-4690-9-S2-P10 PG 1 WC Virology SC Virology GA 015UO UT WOS:000309472100083 ER PT J AU Joachim, A Nilsson, C Aboud, S Lyamuya, EF Robb, M Marovich, M Ochsenbauer, C Wahren, B Sandstrom, E Biberfeld, G Ferrari, G Polonis, VR AF Joachim, A. Nilsson, C. Aboud, S. Lyamuya, E. F. Robb, M. Marovich, M. Ochsenbauer, C. Wahren, B. Sandstrom, E. Biberfeld, G. Ferrari, G. Polonis, V. R. TI Antibody-mediated inhibition of HIV-1 elicited by HIV-I DNA priming and boosting with heterologous HIV-1 recombinant MVA in healthy Tanzanian adults SO RETROVIROLOGY LA English DT Meeting Abstract C1 [Joachim, A.; Aboud, S.; Lyamuya, E. F.] Muhimbili Univ Hlth & Allied Sci, Dar Es Salaam, Tanzania. [Nilsson, C.; Wahren, B.; Biberfeld, G.] Karolinska Inst, Inst Infect Dis Control SMI, Stockholm, Sweden. [Robb, M.] Henry M Jackson Fdn, Rockville, MD USA. [Marovich, M.; Polonis, V. R.] Walter Reed Army Inst Res, Rockville, MD USA. [Ochsenbauer, C.] Univ Alabama Birmingham, Dept Med, Birmingham, AL 35294 USA. [Sandstrom, E.] Karolinska Inst KI Sodersjukhuset, Stockholm, Sweden. [Ferrari, G.] Duke Univ, Med Ctr, Dept Surg, Durham, NC 27710 USA. NR 0 TC 0 Z9 0 U1 1 U2 4 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1742-4690 J9 RETROVIROLOGY JI Retrovirology PD SEP 13 PY 2012 VL 9 SU 2 AR O53 DI 10.1186/1742-4690-9-S2-O53 PG 1 WC Virology SC Virology GA 015UO UT WOS:000309472100054 ER PT J AU Liao, L Bonsignori, M Hwang, K Moody, AM Park, R Crawford, S Chen, H Jeffries, TL Cooper, M Lu, X De, R Karasavvas, N Rerks-Ngarm, S Nitayaphan, S Kaewkungwal, J Tovanabutra, S Pitisuttithum, P Tartaglia, J Sinangil, F Kim, J Michael, NL Tomaras, GD Yang, Z Dai, K Pancera, M Nabel, GJ Mascola, JR Kwong, PD Pinter, A Zolla-Pazner, S Alam, MS Haynes, BF AF Liao, L. Bonsignori, M. Hwang, K. Moody, A. M. Park, R. Crawford, S. Chen, H. Jeffries, T. L. Cooper, M. Lu, X. De, R. Karasavvas, N. Rerks-Ngarm, S. Nitayaphan, S. Kaewkungwal, J. Tovanabutra, S. Pitisuttithum, P. Tartaglia, J. Sinangil, F. Kim, J. Michael, N. L. Tomaras, G. D. Yang, Z. Dai, K. Pancera, M. Nabel, G. J. Mascola, J. R. Kwong, P. D. Pinter, A. Zolla-Pazner, S. Alam, M. S. Haynes, B. F. TI Design of an HIV Env antigen that binds with high affinity to antibodies against linear, conformational and broadly neutralizing epitopes within V1/V2 SO RETROVIROLOGY LA English DT Meeting Abstract C1 [Liao, L.; Bonsignori, M.; Hwang, K.; Moody, A. M.; Park, R.; Crawford, S.; Chen, H.; Jeffries, T. L.; Cooper, M.; Lu, X.; De, R.; Tomaras, G. D.; Alam, M. S.; Haynes, B. F.] Duke Univ, Med Ctr, Durham, NC USA. [Karasavvas, N.; Tovanabutra, S.; Kim, J.; Michael, N. L.] Walter Reed Army Inst Res, US MHRP, Silver Spring, MD USA. [Rerks-Ngarm, S.] Minist Publ Hlth, Dept Dis Control, Nonthaburi, Thailand. [Nitayaphan, S.] AFRIMS, US Army Med Component, Dept Retrovirol, Bangkok, Thailand. [Kaewkungwal, J.] Mahidol Univ, Fac Trop Med, BIOPHICS, Bangkok 10700, Thailand. [Tartaglia, J.] Sanofi Pasteur, Dept Res & Dev, Swiftwater, PA USA. [Sinangil, F.] Global Solut Infect Dis, San Francisco, CA USA. [Yang, Z.; Dai, K.; Pancera, M.; Nabel, G. J.; Mascola, J. R.; Kwong, P. D.] NIH, Vaccine Res Ctr, Bethesda, MD 20892 USA. [Pinter, A.] Univ Med & Dent New Jersey, New Jersey Med Sch, Publ Hlth Res Inst Ctr, Newark, NJ 07103 USA. [Zolla-Pazner, S.] Vet Affairs New York Harbor Healthcare Syst, New York, NY USA. RI Tomaras, Georgia/J-5041-2016 NR 0 TC 1 Z9 1 U1 0 U2 5 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1742-4690 J9 RETROVIROLOGY JI Retrovirology PD SEP 13 PY 2012 VL 9 SU 2 AR O31 DI 10.1186/1742-4690-9-S2-O31 PG 2 WC Virology SC Virology GA 015UO UT WOS:000309472100032 ER PT J AU Matyas, GR Jobe, O Wieczorek, L Peachman, KK Beck, Z Polonis, VR Rao, M Alving, CR AF Matyas, G. R. Jobe, O. Wieczorek, L. Peachman, K. K. Beck, Z. Polonis, V. R. Rao, M. Alving, C. R. TI Cross-clade neutralization of HIV-1 by a monoclonal antibody obtained by immunization with liposomes containing lipid A and a synthetic MPER peptide SO RETROVIROLOGY LA English DT Meeting Abstract C1 [Matyas, G. R.; Polonis, V. R.; Rao, M.; Alving, C. R.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Jobe, O.; Wieczorek, L.; Peachman, K. K.; Beck, Z.] WRAIR, MHRP, Silver Spring, MD USA. [Jobe, O.; Wieczorek, L.; Peachman, K. K.; Beck, Z.] Henry Jackson Fdn, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1742-4690 J9 RETROVIROLOGY JI Retrovirology PD SEP 13 PY 2012 VL 9 SU 2 AR P4 DI 10.1186/1742-4690-9-S2-P4 PG 1 WC Virology SC Virology GA 015UO UT WOS:000309472100077 ER PT J AU Ngauy, V Slike, B Marovich, M AF Ngauy, V. Slike, B. Marovich, M. TI Pre-existing humoral immunity in military smallpox vaccinees temporally effects MVA-vectored transgene expression in dendritic cells SO RETROVIROLOGY LA English DT Meeting Abstract C1 [Ngauy, V.] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. NR 0 TC 0 Z9 0 U1 0 U2 0 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1742-4690 J9 RETROVIROLOGY JI Retrovirology PD SEP 13 PY 2012 VL 9 SU 2 AR P97 DI 10.1186/1742-4690-9-S2-P97 PG 1 WC Virology SC Virology GA 015UO UT WOS:000309472100170 ER PT J AU Pollara, J Bonsignori, M Moody, M Alam, M Liao, H Hwang, K Pickeral, J Kappes, J Ochsenbauer, C Soderberg, K Gurley, TC Kozink, DM Marshall, DJ Whitesides, JF Montefiori, D Robinson, JE Kaewkungwal, J Nitayaphan, S Pitisuttithum, P Rerks-Ngarm, S Kim, J Michael, N Tomaras, G Haynes, BF Ferrari, G AF Pollara, J. Bonsignori, M. Moody, M. Alam, M. Liao, H. Hwang, K. Pickeral, J. Kappes, J. Ochsenbauer, C. Soderberg, K. Gurley, T. C. Kozink, D. M. Marshall, D. J. Whitesides, J. F. Montefiori, D. Robinson, J. E. Kaewkungwal, J. Nitayaphan, S. Pitisuttithum, P. Rerks-Ngarm, S. Kim, J. Michael, N. Tomaras, G. Haynes, B. F. Ferrari, G. TI Vaccine-induced ADCC-mediating antibodies target unique and overlapping envelope epitopes SO RETROVIROLOGY LA English DT Meeting Abstract C1 [Pollara, J.; Bonsignori, M.; Moody, M.; Alam, M.; Liao, H.; Hwang, K.; Pickeral, J.; Soderberg, K.; Gurley, T. C.; Kozink, D. M.; Marshall, D. J.; Whitesides, J. F.; Montefiori, D.; Tomaras, G.; Haynes, B. F.; Ferrari, G.] Duke Univ, Durham, NC USA. [Kappes, J.; Ochsenbauer, C.] Univ Alabama Birmingham, Birmingham, AL USA. [Robinson, J. E.] Tulane Univ, Sch Med, New Orleans, LA 70112 USA. [Kaewkungwal, J.; Pitisuttithum, P.] Mahidol Univ, Bangkok 10700, Thailand. [Nitayaphan, S.] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Rerks-Ngarm, S.] Minist Publ Hlth, Dept Dis Control, Nonthaburi, Thailand. [Kim, J.; Michael, N.] US Mil HIV Res Program, Rockville, MD USA. RI Tomaras, Georgia/J-5041-2016 NR 0 TC 0 Z9 0 U1 0 U2 2 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1742-4690 J9 RETROVIROLOGY JI Retrovirology PD SEP 13 PY 2012 VL 9 SU 2 AR O39 DI 10.1186/1742-4690-9-S2-O39 PG 1 WC Virology SC Virology GA 015UO UT WOS:000309472100040 ER PT J AU Polonis, V Wieczorek, L Kalyanaraman, V Matyas, G Whitney, S Williams, C Tovanabutra, S Sanders-Buell, E Wesberry, M Ochsenbauer, C Chenine, A Rao, M Tong, T Alving, C Cheng, H Zolla-Pazner, S Michael, N VanCott, T Marovich, M AF Polonis, V. Wieczorek, L. Kalyanaraman, V. Matyas, G. Whitney, S. Williams, C. Tovanabutra, S. Sanders-Buell, E. Wesberry, M. Ochsenbauer, C. Chenine, A. Rao, M. Tong, T. Alving, C. Cheng, H. Zolla-Pazner, S. Michael, N. VanCott, T. Marovich, M. TI Antigenicity and immunogenicity of a novel, acute HIV-1 Tanzanian subtype C gp145 envelope protein for clinical development SO RETROVIROLOGY LA English DT Meeting Abstract C1 [Polonis, V.; Matyas, G.; Rao, M.; Alving, C.; Michael, N.; Marovich, M.] Walter Reed Army Inst Res, Div Retrovirol, Silver Spring, MD USA. [Wieczorek, L.; Tovanabutra, S.; Sanders-Buell, E.; Wesberry, M.; Chenine, A.; Tong, T.] Henry M Jackson Fdn, Silver Spring, MD USA. [Kalyanaraman, V.; Whitney, S.; VanCott, T.] Adv Biosci Labs Inc, Rockville, MD USA. [Williams, C.; Zolla-Pazner, S.] NYU, Sch Med, New York, NY USA. [Ochsenbauer, C.] Univ Alabama Birmingham, Birmingham, AL USA. [Cheng, H.] Univ Calif Davis, Davis, CA 95616 USA. NR 0 TC 1 Z9 1 U1 0 U2 1 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1742-4690 J9 RETROVIROLOGY JI Retrovirology PD SEP 13 PY 2012 VL 9 SU 2 AR P323 DI 10.1186/1742-4690-9-S2-P323 PG 1 WC Virology SC Virology GA 015UO UT WOS:000309472100396 ER PT J AU Rao, M Karasavvas, N Pinter, A Liao, H Bonsignori, M Mathieson, B Zolla-Pazner, S Haynes, BF Michael, NL Kim, JH Alving, CR Peachman, KK AF Rao, M. Karasavvas, N. Pinter, A. Liao, H. Bonsignori, M. Mathieson, B. Zolla-Pazner, S. Haynes, B. F. Michael, N. L. Kim, J. H. Alving, C. R. Peachman, K. K. TI Detection of antibodies to the alpha 4 beta 7 integrin binding site on HIV-1 gp120 V2 loop using a novel cell adhesion assay SO RETROVIROLOGY LA English DT Meeting Abstract C1 [Rao, M.; Michael, N. L.; Kim, J. H.; Alving, C. R.] US Mil HIV Res Program, WRAIR, Silver Spring, MD USA. [Karasavvas, N.] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Pinter, A.] Int Cente, Publ Hlth Res Inst Ctr, Newark, NJ USA. [Liao, H.; Bonsignori, M.; Haynes, B. F.] Duke Univ, Med Ctr, Duke Human Vaccine Inst, Durham, NC USA. [Mathieson, B.] NIH, Off AIDS Res, Bethesda, MD 20892 USA. [Zolla-Pazner, S.] NYU, Sch Med, New York, NY USA. [Peachman, K. K.] US Mil HIV Res Program, WRAIR HJF, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1742-4690 J9 RETROVIROLOGY JI Retrovirology PD SEP 13 PY 2012 VL 9 SU 2 AR P71 DI 10.1186/1742-4690-9-S2-P71 PG 1 WC Virology SC Virology GA 015UO UT WOS:000309472100144 ER PT J AU Sholukh, AM Siddappa, NB Shanmuganathan, V Lakhashe, SK Rasmussen, RA Watkins, JD Vyas, HK Mukhtar, MM Hemashettar, G Thorat, S Yoon, JK Villinger, F Novembre, FJ Landucci, G Forthal, DN Ratcliffe, S Robert-Guroff, M Polonis, V Montefiori, DC Ertl, HC Ruprecht, RM AF Sholukh, A. M. Siddappa, N. B. Shanmuganathan, V. Lakhashe, S. K. Rasmussen, R. A. Watkins, J. D. Vyas, H. K. Mukhtar, M. M. Hemashettar, G. Thorat, S. Yoon, J. K. Villinger, F. Novembre, F. J. Landucci, G. Forthal, D. N. Ratcliffe, S. Robert-Guroff, M. Polonis, V. Montefiori, D. C. Ertl, H. C. Ruprecht, R. M. TI Passive immunization with polyclonal anti-SHIV IgG: partial protection or increased acquisition of heterologous tier 2 SHIV - depending on IgG dose SO RETROVIROLOGY LA English DT Meeting Abstract C1 [Villinger, F.; Novembre, F. J.] Yerkes Natl Primate Res Ctr, Atlanta, GA USA. [Villinger, F.; Novembre, F. J.] Emory Univ, Atlanta, GA 30322 USA. [Landucci, G.; Forthal, D. N.] Univ Calif Irvine, Div Infect Dis, Irvine, CA USA. [Ratcliffe, S.] Univ Penn, Philadelphia, PA 19104 USA. [Robert-Guroff, M.] NCI, Vaccine Branch, NIH, Bethesda, MD 20892 USA. [Polonis, V.] Walter Reed Army Inst Res, Mil HIV Res Program, Silver Spring, MD USA. [Montefiori, D. C.] Duke Univ, Sch Med, Dept Surg, Durham, NC USA. [Ertl, H. C.] Wistar Inst Anat & Biol, Philadelphia, PA 19104 USA. [Sholukh, A. M.; Siddappa, N. B.; Lakhashe, S. K.; Rasmussen, R. A.; Watkins, J. D.; Vyas, H. K.; Mukhtar, M. M.; Thorat, S.; Ruprecht, R. M.] Harvard Univ, Sch Med, Dana Farber Canc Inst, Boston, MA 02115 USA. NR 0 TC 0 Z9 0 U1 0 U2 4 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1742-4690 J9 RETROVIROLOGY JI Retrovirology PD SEP 13 PY 2012 VL 9 SU 2 PG 2 WC Virology SC Virology GA 015UO UT WOS:000309472100114 ER PT J AU Slike, BM Tassaneetrithep, B Nitayaphan, S Rono, K Sanga, E Sekiziyivu, A Stablein, D Eller, L Eller, MA Kim, J Michael, N Robb, M Marovich, M AF Slike, B. M. Tassaneetrithep, B. Nitayaphan, S. Rono, K. Sanga, E. Sekiziyivu, A. Stablein, D. Eller, L. Eller, M. A. Kim, J. Michael, N. Robb, M. Marovich, M. TI Early immune events during acute HIV infection SO RETROVIROLOGY LA English DT Meeting Abstract C1 [Slike, B. M.; Eller, L.; Eller, M. A.; Kim, J.; Michael, N.; Robb, M.; Marovich, M.] US Mil HIV Res Program, Silver Spring, MD USA. [Tassaneetrithep, B.] Mahidol Univ, Siriraj Hosp, Bangkok, Thailand. [Nitayaphan, S.] Armed Forces Res Inst Med Sci, Bangkok, Thailand. [Rono, K.] Walter Reed Program, Kericho, Kenya. [Sanga, E.] Mbeya Med Res Programme, Mbeya, Tanzania. [Sekiziyivu, A.] Makerere Univ, Walter Reed Project, Kampala, Uganda. [Stablein, D.] Emmes Corp, Rockville, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1742-4690 J9 RETROVIROLOGY JI Retrovirology PD SEP 13 PY 2012 VL 9 SU 2 AR P181 DI 10.1186/1742-4690-9-S2-P181 PG 1 WC Virology SC Virology GA 015UO UT WOS:000309472100254 ER PT J AU Stephenson, KE Li, H Walker, BD Michael, NL Barouch, DH AF Stephenson, K. E. Li, H. Walker, B. D. Michael, N. L. Barouch, D. H. TI Gag-specific cellular immunity determines in vitro viral inhibition and in vivo virologic control following SIV challenges of vaccinated monkeys SO RETROVIROLOGY LA English DT Meeting Abstract C1 [Stephenson, K. E.; Li, H.; Barouch, D. H.] Beth Israel Deaconess Med Ctr, Boston, MA 02215 USA. [Stephenson, K. E.; Li, H.; Barouch, D. H.] Harvard Univ, Boston, MA 02115 USA. [Walker, B. D.] Ragon Inst MGH MIT & Harvard, Charlestown, MA USA. [Michael, N. L.] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1742-4690 J9 RETROVIROLOGY JI Retrovirology PD SEP 13 PY 2012 VL 9 SU 2 AR P245 DI 10.1186/1742-4690-9-S2-P245 PG 1 WC Virology SC Virology GA 015UO UT WOS:000309472100318 ER PT J AU Wieczorek, L Rao, M Peachman, K Steers, N Marovich, M Michael, N Polonis, V Rao, V AF Wieczorek, L. Rao, M. Peachman, K. Steers, N. Marovich, M. Michael, N. Polonis, V. Rao, V. TI Immunogenic selection of HIV-1 MPER epitopes for improved vaccine design SO RETROVIROLOGY LA English DT Meeting Abstract C1 [Wieczorek, L.; Peachman, K.; Steers, N.] Henry M Jackson Fdn, Silver Spring, MD USA. [Rao, M.; Marovich, M.; Michael, N.; Polonis, V.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Rao, V.] Catholic Univ Amer, Washington, DC 20064 USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1742-4690 J9 RETROVIROLOGY JI Retrovirology PD SEP 13 PY 2012 VL 9 SU 2 AR P322 DI 10.1186/1742-4690-9-S2-P322 PG 1 WC Virology SC Virology GA 015UO UT WOS:000309472100395 ER PT J AU Ciezak-Jenkins, J AF Ciezak-Jenkins, Jennifer TI Derivation of the isothermal equation of state of carbon monoxide to 50 GPa SO CHEMICAL PHYSICS LETTERS LA English DT Article ID X-RAY-DIFFRACTION; HIGH-PRESSURES; SOLID CO; PHASE; POLYMERIZATION; HYDROGEN AB The refractive index of carbon monoxide was derived to near 50 GPa using Infrared reflectivity. Variances in the refractive index near 5.5 GPa were related to a previously identified phase transition. A combination of refractive index and image mapping permitted extraction of the sample thickness as a function of pressure, which when fit with a third-order Birch-Murnaghan EOS, revealed the pressure-volume relationship is in good agreement with X-ray diffraction and a computationally predicted shock Hugoniot of non-reactive carbon monoxide over a limited pressure range. Published by Elsevier B.V. C1 USA, Army Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Ciezak-Jenkins, J (reprint author), USA, Army Res Lab, RDRL WML B Bldg 390, Aberdeen Proving Ground, MD 21005 USA. EM jennifer.a.ciezak-jenkins@us.army.mil FU DOE [DEAC02-98CH10886]; COMPRES; Consortium for Materials Properties Research in Earth Sciences under NSF Cooperative Agreement [EAR01-35554]; US DOE [DEFC03-03N00144] FX Infrared reflectivity measurements were performed at the U2A beamline at the NSLS of BNL (DOE Contract No. DEAC02-98CH10886). The U2A beamline is supported by COMPRES, the Consortium for Materials Properties Research in Earth Sciences, under NSF Cooperative Agreement Grant No. EAR01-35554 and the US DOE (CDAC, Contract No. DEFC03-03N00144). NR 20 TC 0 Z9 0 U1 2 U2 22 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0009-2614 J9 CHEM PHYS LETT JI Chem. Phys. Lett. PD SEP 12 PY 2012 VL 546 BP 86 EP 89 DI 10.1016/j.cplett.2012.07.048 PG 4 WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical SC Chemistry; Physics GA 000SC UT WOS:000308407400015 ER PT J AU Chantawansri, TL Sliozberg, YR Andzelm, JW Hsieh, AJ AF Chantawansri, Tanya L. Sliozberg, Yelena R. Andzelm, Jan W. Hsieh, Alex J. TI Coarse-grained modeling of model poly(urethane urea)s: Microstructure and interface aspects SO POLYMER LA English DT Article DE Poly(urethane urea); Morphology; Mechanical properties ID DISSIPATIVE PARTICLE DYNAMICS; STRESS-STRAIN BEHAVIOR; MOLECULAR-DYNAMICS; MECHANICAL DEFORMATION; GLASS-TRANSITION; PHASE-SEPARATION; POLYMER MELTS; POLYUREA; SIMULATION; COPOLYMERS AB Poly(urethane urea) elastomers are versatile and can be tailored to exhibit a broad range of mechanical response under high strain rate deformation. In this work, we utilize coarse-grained molecular dynamics simulations to elucidate the molecular mechanisms, particularly the effects of hard segment content, intermolecular interaction, and rigidity of the interface between the hard and soft segments on local morphology and rate-dependent stress-strain behavior in the ballistic regime. Simulation results qualitatively agree with available experimental data, where analysis of hard segment orientation during tensile and compression deformation and dynamic strain rate sensitivity was also performed. Further study of the intermolecular interaction on the stress-strain behavior reveals that it has a strong effect on strain hardening, particularly for a rigid interface, once the hard segment content reaches the percolation threshold. Simulation results also show that interface intermolecular interaction could become more dominant over interface rigidity in the initial stress-strain response, particularly below percolation. Published by Elsevier Ltd. C1 [Chantawansri, Tanya L.; Sliozberg, Yelena R.; Andzelm, Jan W.; Hsieh, Alex J.] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Chantawansri, TL (reprint author), USA, Res Lab, 4600 Deer Creek Loop, Aberdeen Proving Ground, MD 21005 USA. EM tanya.chantawansri.civ@mail.mil RI Chantawansri, Tanya/N-3601-2013 FU Director's Research Initiative program at the Army Research Laboratory; U.S. Army Research Laboratory FX The authors would like to thank Professor R. Riggleman (PENN) for useful discussion. Funding has been provided by the Director's Research Initiative program at the Army Research Laboratory. YRS was supported in part by an appointment to the Postgraduate Research Participation Program at the U.S. Army Research Laboratory administered by the Oak Ridge Institute of Science and Education through an interagency agreement between the U.S. Department of Energy and ARL. The DoD HPC Modernization Office supported this project by supplying supercomputer time under the Computing Challenge Project C5M. This computer time was made available at the DoD Major Shared Resources Centers at the AFRL DSRC. NR 45 TC 6 Z9 6 U1 2 U2 48 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0032-3861 J9 POLYMER JI Polymer PD SEP 12 PY 2012 VL 53 IS 20 BP 4512 EP 4524 DI 10.1016/j.polymer.2012.07.056 PG 13 WC Polymer Science SC Polymer Science GA 006XM UT WOS:000308853100025 ER PT J AU Sealfon, R Gire, S Ellis, C Calderwood, S Qadri, F Hensley, L Kellis, M Ryan, ET LaRocque, RC Harris, JB Sabeti, PC AF Sealfon, Rachel Gire, Stephen Ellis, Crystal Calderwood, Stephen Qadri, Firdausi Hensley, Lisa Kellis, Manolis Ryan, Edward T. LaRocque, Regina C. Harris, Jason B. Sabeti, Pardis C. TI High depth, whole-genome sequencing of cholera isolates from Haiti and the Dominican Republic SO BMC GENOMICS LA English DT Article DE Whole-genome sequencing; Vibrio cholerae; Haitian cholera epidemic; Microbial evolution ID TOXIGENIC VIBRIO-CHOLERAE; CTX-PHI; TRANSMISSION; ALIGNMENT AB Background: Whole-genome sequencing is an important tool for understanding microbial evolution and identifying the emergence of functionally important variants over the course of epidemics. In October 2010, a severe cholera epidemic began in Haiti, with additional cases identified in the neighboring Dominican Republic. We used whole-genome approaches to sequence four Vibrio cholerae isolates from Haiti and the Dominican Republic and three additional V. cholerae isolates to a high depth of coverage (> 2000x); four of the seven isolates were previously sequenced. Results: Using these sequence data, we examined the effect of depth of coverage and sequencing platform on genome assembly and identification of sequence variants. We found that 50x coverage is sufficient to construct a whole-genome assembly and to accurately call most variants from 100 base pair paired-end sequencing reads. Phylogenetic analysis between the newly sequenced and thirty-three previously sequenced V. cholerae isolates indicates that the Haitian and Dominican Republic isolates are closest to strains from South Asia. The Haitian and Dominican Republic isolates form a tight cluster, with only four variants unique to individual isolates. These variants are located in the CTX region, the SXT region, and the core genome. Of the 126 mutations identified that separate the Haiti-Dominican Republic cluster from the V. cholerae reference strain (N16961), 73 are non-synonymous changes, and a number of these changes cluster in specific genes and pathways. Conclusions: Sequence variant analyses of V. cholerae isolates, including multiple isolates from the Haitian outbreak, identify coverage-specific and technology-specific effects on variant detection, and provide insight into genomic change and functional evolution during an epidemic. C1 [Sealfon, Rachel; Kellis, Manolis] MIT, CSAIL, Cambridge, MA 02139 USA. [Sealfon, Rachel; Gire, Stephen; Kellis, Manolis; Sabeti, Pardis C.] Broad Inst MIT & Harvard, Cambridge, MA USA. [Gire, Stephen; Sabeti, Pardis C.] Harvard Univ, Dept Organism & Evolutionary Biol, Ctr Syst Biol, Cambridge, MA 02138 USA. [Ellis, Crystal; Calderwood, Stephen; Ryan, Edward T.; LaRocque, Regina C.; Harris, Jason B.] Massachusetts Gen Hosp, Div Infect Dis, Boston, MA 02114 USA. [Ellis, Crystal; Calderwood, Stephen; Ryan, Edward T.; LaRocque, Regina C.] Harvard Univ, Sch Med, Dept Med, Boston, MA USA. [Qadri, Firdausi] Int Ctr Diarrheal Dis Res, Dhaka, Bangladesh. [Hensley, Lisa] USA, Inst Infect Dis, Ft Detrick, MD USA. [Ryan, Edward T.; Sabeti, Pardis C.] Harvard Univ, Sch Publ Hlth, Dept Immunol & Infect Dis, Cambridge, MA 02138 USA. [Harris, Jason B.] Harvard Univ, Sch Med, Dept Pediat, Boston, MA 02115 USA. RP Sealfon, R (reprint author), MIT, CSAIL, 77 Massachusetts Ave, Cambridge, MA 02139 USA. EM rsealfon@mit.edu; pardis@broadinstitute.org FU NDSEG fellowship; Physician Scientist Early Career Award from the Howard Hughes Medical Institute; Charles H. Hood Foundation Child Health Research Award; International Research Scientist Development Award [K01 TW0/144]; USAMRIID award [W81XWH-11-1-0141] FX RS was supported by an NDSEG fellowship. RCL was supported by a Physician Scientist Early Career Award from the Howard Hughes Medical Institute. JBH was supported by a Charles H. Hood Foundation Child Health Research Award (J. B. H.) and an International Research Scientist Development Award (K01 TW0/144). PCS and this work were supported by USAMRIID award W81XWH-11-1-0141. NR 34 TC 4 Z9 5 U1 0 U2 13 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1471-2164 J9 BMC GENOMICS JI BMC Genomics PD SEP 11 PY 2012 VL 13 AR 468 DI 10.1186/1471-2164-13-468 PG 11 WC Biotechnology & Applied Microbiology; Genetics & Heredity SC Biotechnology & Applied Microbiology; Genetics & Heredity GA 022BG UT WOS:000309929400002 PM 22963323 ER PT J AU Arnold, BR Roberson, SD Pellegrino, PM AF Arnold, Bradley R. Roberson, Stephen D. Pellegrino, Paul M. TI Excited state dynamics of nitrogen reactive intermediates at the threshold of laser induced filamentation SO CHEMICAL PHYSICS LA English DT Article DE Filamentation; Nitrogen excited states; Time-resolved emission spectroscopy; Electron density ID ELECTRIC-FIELD STRENGTH; INTENSITY RATIO; SPECTRAL BANDS; MOLECULAR NITROGEN; LIGHT FILAMENTS; PULSE; PLASMAS; AIR; SPECTROSCOPY; EMISSION AB It has been suggested that the process of laser induced filamentation can be used in a wide range of applications such as: material processing, controlled electric discharge, and innovative spectroscopic measurements including the remote sensing of pollutants and hazardous materials. During filamentation, emissions from small excited molecular species and atomic states, both neutral and ionic, are readily observed. Among the important excited state species observed in air is the excited triplet state of molecular nitrogen, N-2(C-3 Pi(u)). A method used to measure the emission properties of the excited states of nitrogen during filamentation is described. These measurements indicate that intersystem crossing from an excited singlet state is the dominate path to produce the triplet state. Alternative pathways, including neutralization of cationic species, were shown to be minor contributors under the laser-induced filamentation conditions of this study. (C) 2012 Elsevier B.V. All rights reserved. C1 [Arnold, Bradley R.] Univ Maryland Baltimore Cty, Dept Chem & Biochem, Baltimore, MD 21250 USA. [Arnold, Bradley R.; Roberson, Stephen D.; Pellegrino, Paul M.] USA, RDRL SEE O, Res Lab, Adelphi, MD 20783 USA. RP Arnold, BR (reprint author), Univ Maryland Baltimore Cty, Dept Chem & Biochem, 1000 Hilltop Circle, Baltimore, MD 21250 USA. EM barnold@umbc.edu FU MPCA; 'RDECOM-ARL: Army Research Laboratory' under U.S. Army Research Office Scientific Services Program [W911NF-07-D-0001]; Department of Chemistry and Biochemistry at UMBC FX The authors wish to acknowledge the MPCA for partial support of this research. BRA further acknowledges support by the 'RDECOM-ARL: Army Research Laboratory' under the auspices of the U.S. Army Research Office Scientific Services Program administered by Battelle (Delivery Order 0979; Contract No. W911NF-07-D-0001) and the Department of Chemistry and Biochemistry at UMBC. NR 38 TC 11 Z9 11 U1 0 U2 9 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0301-0104 J9 CHEM PHYS JI Chem. Phys. PD SEP 11 PY 2012 VL 405 BP 9 EP 15 DI 10.1016/j.chemphys.2012.05.019 PG 7 WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical SC Chemistry; Physics GA 004ZQ UT WOS:000308720500002 ER PT J AU Persans, PD Berry, NE Recht, D Hutchinson, D Peterson, H Clark, J Charnvanichborikarn, S Williams, JS DiFranzo, A Aziz, MJ Warrender, JM AF Persans, Peter D. Berry, Nathaniel E. Recht, Daniel Hutchinson, David Peterson, Hannah Clark, Jessica Charnvanichborikarn, Supakit Williams, James S. DiFranzo, Anthony Aziz, Michael J. Warrender, Jeffrey M. TI Photocarrier lifetime and transport in silicon supersaturated with sulfur SO APPLIED PHYSICS LETTERS LA English DT Article ID SOLAR-CELLS; RECOMBINATION AB Doping of silicon-on-insulator layers with sulfur to concentrations far above equilibrium by ion implantation and pulsed laser melting can result in large concentration gradients. Photocarriers generated in and near the impurity gradient can separate into different coplanar transport layers, leading to enhanced photocarrier lifetimes in thin silicon-on-insulator films. The depth from which holes escape the heavily doped region places a lower limit on the minority carrier mobility-lifetime product of 10(-8) cm(2)/V for heavily sulfur doped silicon. We conclude that the cross-section for recombination through S impurities at this concentration is significantly reduced relative to isolated impurities. (C) 2012 American Institute of Physics. [http://dx.doi.org/10.1063/1.4746752] C1 [Persans, Peter D.; Berry, Nathaniel E.; Hutchinson, David; Peterson, Hannah; Clark, Jessica; DiFranzo, Anthony] Rensselaer Polytech Inst, Troy, NY 12180 USA. [Recht, Daniel; Williams, James S.; Aziz, Michael J.] Harvard Univ, Sch Engn & Appl Sci, Cambridge, MA 02138 USA. [Peterson, Hannah; Warrender, Jeffrey M.] USA, ARDEC, Benet Labs, Watervliet, NY 12189 USA. [Charnvanichborikarn, Supakit; Williams, James S.] Australian Natl Univ, Res Sch Phys & Engn, Canberra, ACT 0200, Australia. RP Persans, PD (reprint author), Rensselaer Polytech Inst, 110 8th St, Troy, NY 12180 USA. FU Army Research Office [W911NF0910470]; NSF REU program at Rensselaer; US Army ARDEC [W15QKN-07-P-0092]; National Defense Science and Engineering Graduate fellowship FX Research at Rensselaer was supported by the Army Research Office under Contract No. W911NF0910470 and by the NSF REU program at Rensselaer. Research at Harvard was supported by US Army ARDEC under Contract No. W15QKN-07-P-0092. D.R. was supported in part by a National Defense Science and Engineering Graduate fellowship. We thank Athena Pan and Mark Winkler for access to unpublished data. We thank William Cunningham, David Lombardo, Andrew McAllister, Christina McGahan, Jeremy Mehta, and Drew Rosen for technical assistance. NR 23 TC 11 Z9 11 U1 2 U2 30 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD SEP 10 PY 2012 VL 101 IS 11 AR 111105 DI 10.1063/1.4746752 PG 4 WC Physics, Applied SC Physics GA 013TR UT WOS:000309329300005 ER PT J AU Yao, CW Garvin, TP Alvarado, JL Jacobi, AM Jones, BG Marsh, CP AF Yao, C. W. Garvin, T. P. Alvarado, J. L. Jacobi, A. M. Jones, B. G. Marsh, C. P. TI Droplet contact angle behavior on a hybrid surface with hydrophobic and hydrophilic properties SO APPLIED PHYSICS LETTERS LA English DT Article ID ARTIFICIAL SUPERHYDROPHOBIC SURFACES; GROWTH DYNAMICS; HEAT-TRANSFER; CONDENSATION; WATER; WETTABILITY; HYSTERESIS; EQUATION AB A hybrid surface consisting of an array of hydrophobic and hydrophilic sites was designed and fabricated in an effort to better understand the effects of microscale surface features and chemistry on wettability. A model based on energy minimization was developed to design and predict the wettability of hybrid surfaces. Measured advancing, receding, and equilibrium contact angles fit the proposed model well. Experiments show that a higher degree of hydrophobicity results in higher contact angles and that contact angle hysteresis increases with decreasing micropillar spacing (b/a). Moreover, measured roll-off angle as an indicator of droplet shedding, decreases with b/a. (C) 2012 American Institute of Physics. [http://dx.doi.org/10.1063/1.4752470] C1 [Yao, C. W.] Texas A&M Univ, Dept Mech Engn, College Stn, TX 77843 USA. [Garvin, T. P.; Marsh, C. P.] Erdc, Construct Engn Res Lab, Champaign, IL 61826 USA. [Garvin, T. P.; Jacobi, A. M.] Univ Illinois, Dept Mech Sci & Engn, Urbana, IL 61801 USA. [Alvarado, J. L.] Texas A&M Univ, Dept Engn Technol & Ind Distribut, College Stn, TX 77843 USA. [Jones, B. G.; Marsh, C. P.] Univ Illinois, Dept Nucl Plasma & Radiol Engn, Champaign, IL 61801 USA. RP Yao, CW (reprint author), Texas A&M Univ, Dept Mech Engn, College Stn, TX 77843 USA. EM alvarado@entc.tamu.edu RI Yao, Chun-Wei/K-4271-2016; OI Yao, Chun-Wei/0000-0002-9032-9592; Alvarado, Jorge/0000-0002-4059-6588 NR 32 TC 9 Z9 9 U1 3 U2 75 PU AMER INST PHYSICS PI MELVILLE PA 1305 WALT WHITMAN RD, STE 300, MELVILLE, NY 11747-4501 USA SN 0003-6951 EI 1077-3118 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD SEP 10 PY 2012 VL 101 IS 11 AR 111605 DI 10.1063/1.4752470 PG 5 WC Physics, Applied SC Physics GA 013TR UT WOS:000309329300017 ER PT J AU Ogden, FL Harmon, RS AF Ogden, Fred L. Harmon, Russell S. TI Editorial: Special issue of J. Hydrology on Tropical Hydrology SO JOURNAL OF HYDROLOGY LA English DT Editorial Material ID CENTRAL-AMERICA; SOIL; FORESTS; TREES C1 [Ogden, Fred L.] Univ Wyoming, Dept Civil & Architectural Engn 3295, Laramie, WY 82071 USA. [Harmon, Russell S.] US Army Corps Engineers, Int Res Off, Engineer Res & Dev Ctr, Ruislip HA4 7HB, England. RP Ogden, FL (reprint author), Univ Wyoming, Dept Civil & Architectural Engn 3295, Laramie, WY 82071 USA. EM fogden@uwyo.edu; russell.s.harmon@usace.army.mil NR 24 TC 1 Z9 1 U1 0 U2 3 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0022-1694 J9 J HYDROL JI J. Hydrol. PD SEP 10 PY 2012 VL 462 SI SI BP 1 EP 3 DI 10.1016/j.jhydrol.2012.07.017 PG 3 WC Engineering, Civil; Geosciences, Multidisciplinary; Water Resources SC Engineering; Geology; Water Resources GA 009GY UT WOS:000309015400001 ER PT J AU Zhang, MY Yuan, TT Li, JJ Borges, AR Watkins, JD Guenaga, J Yang, Z Wang, YP Wilson, R Li, YX Polonis, VR Pincus, SH Ruprecht, RM Dimitrov, DS AF Zhang, Mei-Yun Yuan, Tingting Li, Jingjing Borges, Andrew Rosa Watkins, Jennifer D. Guenaga, Javier Yang, Zheng Wang, Yanping Wilson, Richard Li, Yuxing Polonis, Victoria R. Pincus, Seth H. Ruprecht, Ruth M. Dimitrov, Dimiter S. TI Identification and Characterization of a Broadly Cross-Reactive HIV-1 Human Monoclonal Antibody That Binds to Both gp120 and gp41 SO PLOS ONE LA English DT Article ID IMMUNODEFICIENCY-VIRUS TYPE-1; NEUTRALIZING ANTIBODIES; IN-VIVO; CRYSTAL-STRUCTURE; ENVELOPE PROTEIN; PHAGE LIBRARY; POTENT; CELL; FUSION; RECOGNIZES AB Identification of broadly cross-reactive HIV-1-neutralizing antibodies (bnAbs) may assist vaccine immunogen design. Here we report a novel human monoclonal antibody (mAb), designated m43, which co-targets the gp120 and gp41 subunits of the HIV-1 envelope glycoprotein (Env). M43 bound to recombinant gp140 s from various primary isolates, to membrane-associated Envs on transfected cells and HIV-1 infected cells, as well as to recombinant gp120 s and gp41 fusion intermediate structures containing N-trimer structure, but did not bind to denatured recombinant gp140 s and the CD4 binding site (CD4bs) mutant, gp120 D368R, suggesting that the m43 epitope is conformational and overlaps the CD4bs on gp120 and the N-trimer structure on gp41. M43 neutralized 34% of the HIV-1 primary isolates from different clades and all the SHIVs tested in assays based on infection of peripheral blood mononuclear cells (PBMCs) by replication-competent virus, but was less potent in cell line-based pseudovirus assays. In contrast to CD4, m43 did not induce Env conformational changes upon binding leading to exposure of the coreceptor binding site, enhanced binding of mAbs 2F5 and 4E10 specific for the membrane proximal external region (MPER) of gp41 Envs, or increased gp120 shedding. The overall modest neutralization activity of m43 is likely due to the limited binding of m43 to functional Envs which could be increased by antibody engineering if needed. M43 may represent a new class of bnAbs targeting conformational epitopes overlapping structures on both gp120 and gp41. Its novel epitope and possibly new mechanism(s) of neutralization could helpdesign improved vaccine immunogens and candidate therapeutics. C1 [Zhang, Mei-Yun; Yuan, Tingting; Li, Jingjing; Yang, Zheng] Univ Hong Kong, AIDS Inst, Li Ka Shing Fac Med, Hong Kong, Hong Kong, Peoples R China. [Zhang, Mei-Yun; Yuan, Tingting; Li, Jingjing; Yang, Zheng] Univ Hong Kong, Dept Microbiol, Li Ka Shing Fac Med, Hong Kong, Hong Kong, Peoples R China. [Borges, Andrew Rosa] Henry M Jackson Fdn, Dept Vaccine Res, US Mil HIV Res Program, Rockville, MD USA. [Watkins, Jennifer D.; Ruprecht, Ruth M.] Dana Farber Canc Inst, Boston, MA 02115 USA. [Watkins, Jennifer D.; Ruprecht, Ruth M.] Harvard Univ, Sch Med, Boston, MA USA. [Guenaga, Javier; Wilson, Richard; Li, Yuxing] Scripps Res Inst, Dept Immunol & Microbial Sci, Int AIDS Vaccine Initiat Neutralizing Antibody Ct, La Jolla, CA 92037 USA. [Wang, Yanping; Dimitrov, Dimiter S.] NCI, CCRNP, Ctr Canc Res, NIH, Frederick, MD 21701 USA. [Polonis, Victoria R.] Walter Reed Army Inst Res, Div Retrovirol, US Mil HIV Res Program, Rockville, MD USA. [Pincus, Seth H.] Childrens Hosp, New Orleans, LA USA. [Pincus, Seth H.] Louisiana State Univ, Hlth Sci Ctr, New Orleans, LA USA. RP Zhang, MY (reprint author), Univ Hong Kong, AIDS Inst, Li Ka Shing Fac Med, Hong Kong, Hong Kong, Peoples R China. EM zhangmy@hku.hk OI Yang, Zheng/0000-0003-0217-6694 FU Intramural Research Program of the University of Hong Kong; Hong Kong Research Grants Council (RGC) General Research Fund (GRF) grant [785210]; National Institutes of Health (NIH) [R37 AI034266, P01 AI048240]; Intramural Research Program of the Center for Cancer Research, National Cancer Institute, NIH; Bill and Melinda Gates Foundation FX This work was supported by the Intramural Research Program of the University of Hong Kong, and by Hong Kong Research Grants Council (RGC) General Research Fund (GRF) grant #785210 to MYZ, National Institutes of Health (NIH) R37 AI034266 and P01 AI048240 to RMR, and by the Intramural Research Program of the Center for Cancer Research, National Cancer Institute, NIH, and the Bill and Melinda Gates Foundation to DSD. The content of this publication does not necessarily reflect the views or policies of the Department of Health and Human Services, nor does the mention of trade names, commercial products, or organizations imply endorsement by the United States Government. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 50 TC 16 Z9 16 U1 1 U2 8 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD SEP 10 PY 2012 VL 7 IS 9 AR e44241 DI 10.1371/journal.pone.0044241 PG 14 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 005KD UT WOS:000308748400013 PM 22970187 ER PT J AU Hong, SK Epureanu, BI Castanier, MP AF Hong, Sung-Kwon Epureanu, Bogdan I. Castanier, Matthew P. TI Joining of components of complex structures for improved dynamic response SO JOURNAL OF SOUND AND VIBRATION LA English DT Article ID GENERALIZED SHAPE OPTIMIZATION; TOPOLOGY OPTIMIZATION; EVOLUTIONARY PROCEDURE; DESIGN; SYSTEMS; MODELS; HOMOGENIZATION; FREQUENCY; LAYOUT AB The goal of this work is to provide a method for choosing joining (e.g., bolt) locations for attaching structural reinforcements onto complex structures. The joining locations affect structural performance criteria such as the frequency response and the static compliance of the modified structure. One approach to finding improved/optimal joining locations is to place the joints such that the total amount of energy input into the structure (from external forces) is lowered/minimized, thus ensuring that the performance of the structure is least affected by the structural modifications. However, such an approach does not account for the stresses in the joints. Therefore, in this work, the amount of strain energy concentrated in the joints is also considered. The cost function for this optimization problem is then composed of two energies. These energies are different for the undamped and damped cases. Herein, the focus is on the (more realistic) damped case. The cost function is minimized by a modified optimality criteria method. This process is time consuming because it requires the calculation of sensitivities of the joint strain energy, which in turn requires the calculation of the displacements of all candidate joint locations by using the system-level mass and stiffness matrices and force vector (at each frequency in the range of interest). To address this issue, a series of complex algebraic manipulations and approximations are used to significantly reduce the computational cost. In addition, for the case where structural and geometrical variations are necessary, parametric reduced-order models are used to compute the cost function with further significant gains in computational speed. Numerical results for improved/optimal joining are presented for representative complex structures with structural variabilities. (C) 2012 Elsevier Ltd. All rights reserved. C1 [Hong, Sung-Kwon; Epureanu, Bogdan I.] Univ Michigan, Dept Mech Engn, Ann Arbor, MI 48109 USA. [Castanier, Matthew P.] USA, Tank Automot Res Dev & Engn Ctr, Warren, MI 48397 USA. RP Epureanu, BI (reprint author), Univ Michigan, Dept Mech Engn, 2350 Hayward St, Ann Arbor, MI 48109 USA. EM sungkwon@umich.edu; epureanu@umich.edu; matt.castanier@us.army.mil OI Castanier, Matthew/0000-0002-3646-382X FU Automotive Research Center; Automotive Research Center, a U.S. Army Center of Excellence for Modeling and Simulation of Ground Vehicles FX The authors gratefully acknowledge the financial support of the Automotive Research Center, a U.S. Army Center of Excellence for Modeling and Simulation of Ground Vehicles led by the University of Michigan. NR 40 TC 2 Z9 2 U1 1 U2 10 PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD PI LONDON PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND SN 0022-460X EI 1095-8568 J9 J SOUND VIB JI J. Sound Vibr. PD SEP 10 PY 2012 VL 331 IS 19 BP 4285 EP 4298 DI 10.1016/j.jsv.2012.05.004 PG 14 WC Acoustics; Engineering, Mechanical; Mechanics SC Acoustics; Engineering; Mechanics GA 980HM UT WOS:000306884200006 ER PT J AU Yang, J Jones, KF Yu, W Morris, R AF Yang, Jing Jones, Kathleen F. Yu, Wei Morris, Robert TI Simulation of in-cloud icing events on Mount Washington with the GEM-LAM SO JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES LA English DT Article ID BULK MICROPHYSICS SCHEME; ATMOSPHERIC BOUNDARY-LAYER; FINITE-ELEMENT MODEL; PART I; EXPLICIT FORECASTS; PARAMETERIZATION; PREDICTION; SENSITIVITY; SNOW; IMPLEMENTATION AB In-cloud icing on structures such as transmission lines and wind turbines is an important consideration both for design and operations. It often occurs in coastal areas and over high terrain, where there are virtually no systematic observations. The regional mesoscale model GEM-LAM of the Canadian Meteorological Center (CMC) was used to model three historical icing events on Mount Washington, where observational data were available. These three events are representative of the most frequent low level wind directions for seven available observation periods. A newly developed sophisticated two-moment microphysics scheme (Milbrandt-Yau) is used in GEM-LAM. The simulated cloud properties and other meteorological data are compared with near surface observational data. Simulation results from the 1-km resolution run agree best with the observations, with an average RMSE (root mean square error) of 1.6 degrees C for near surface temperature, 4.6 m s(-1) for wind speed, 0.23 g m(-3) for liquid water content, and 5.8 mu m for the median volume droplet diameter. These simulated meteorological fields and cloud properties were used as inputs to a cylindrical sleeve icing model. The modeled icing rate from the GEM-LAM simulated fields follows the temporal evolution of the observed one with average RMSE of 1.53 g m(-1) min(-1) compared to an average measured icing rate of 1.98 g m(-1) min(-1) for all the three cases. C1 [Yang, Jing; Yu, Wei] Environm Canada, Meteorol Res Div, Dorval, PQ H9P 1J3, Canada. [Yang, Jing; Morris, Robert] Environm Canada, Adaptat & Impacts Res Sect, Dorval, PQ H9P 1J3, Canada. [Jones, Kathleen F.] USA, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. RP Yang, J (reprint author), Environm Canada, Meteorol Res Div, 2121 Transcanada Hwy 500, Dorval, PQ H9P 1J3, Canada. EM jing.yang@ec.gc.ca FU Antoine Lacoix; Clean Energy Fund project Forecasting and Estimating Atmospheric Icing on Wind Turbines [CE-015]; National Sciences and Engineering Research Council (NSERC) FX The authors wish to express their appreciation for the support provided by Antoine Lacoix, the Clean Energy Fund project (CE-015) Forecasting and Estimating Atmospheric Icing on Wind Turbines and the National Sciences and Engineering Research Council (NSERC). The numerical simulations were performed on the supercomputers at CMC Supercomputer Center. The authors are grateful to Andre Plante of CMC for helping set up the model configuration, David Straub of McGill University and Jason Milbrandt of RPN for useful discussions and suggestions, and three reviewers for constructive comments, which greatly improved the quality of this article. NR 67 TC 5 Z9 5 U1 0 U2 1 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA SN 2169-897X J9 J GEOPHYS RES-ATMOS JI J. Geophys. Res.-Atmos. PD SEP 8 PY 2012 VL 117 AR D17204 DI 10.1029/2012JD017520 PG 21 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA 003DA UT WOS:000308587200002 ER PT J AU Bergmann-Leitner, ES Duncan, EH Mease, RM Angov, E AF Bergmann-Leitner, Elke S. Duncan, Elizabeth H. Mease, Ryan M. Angov, Evelina TI Impact of pre-existing MSP1(42)-allele specific immunity on potency of an erythrocytic Plasmodium falciparum vaccine SO MALARIA JOURNAL LA English DT Article DE Pre-existing immunity; Plasmodium; Vaccine; Erythrocytic stage; Merozoite surface protein-1; Clonal imprinting ID MEROZOITE SURFACE PROTEIN-1; STAGE MALARIA VACCINE; CARBOXYL-TERMINAL REGION; IMMUNOGENICITY TRIAL; ANTIBODY-RESPONSES; ACQUIRED-IMMUNITY; GROWTH-INHIBITION; KENYAN CHILDREN; MALIAN ADULTS; ANTIGEN AB Background: MSP1 is the major surface protein on merozoites and a prime candidate for a blood stage malaria vaccine. Preclinical and seroepidemiological studies have implicated antibodies to MSP1 in protection against blood stage parasitaemia and/or reduced parasite densities, respectively. Malaria endemic areas have multiple strains of Plasmodium falciparum circulating at any given time, giving rise to complex immune responses, an issue which is generally not addressed in clinical trials conducted in non-endemic areas. A lack of understanding of the effect of pre-existing immunity to heterologous parasite strains may significantly contribute to vaccine failure in the field. The purpose of this study was to model the effect of pre-existing immunity to MSP1(42) on the immunogenicity of blood-stage malaria vaccines based on alternative MSP1 alleles. Methods: Inbred and outbred mice were immunized with various recombinant P. falciparum MSP142 proteins that represent the two major alleles of MSP1(42), MAD20 (3D7) and Wellcome (K1, FVO). Humoral immune responses were analysed by ELISA and Luminex (TM), and functional activity of induced MSP1(42)-specific antibodies was assessed by growth inhibition assays. T-cell responses were characterized using ex vivo ELISpot assays. Results: Analysis of the immune responses induced by various immunization regimens demonstrated a strong allele-specific response at the T cell level in both inbred and outbred mice. The success of heterologous regimens depended on the degree of homology of the N-terminal p33 portion of the MSP1(42), likely due to the fact that most T cell epitopes reside in this part of the molecule. Analysis of humoral immune responses revealed a marked cross-reactivity between the alleles. Functional analyses showed that some of the heterologous regimens induced antibodies with improved growth inhibitory activities. Conclusion: The development of a more broadly efficacious MSP1 based vaccine may be hindered by clonally imprinted p33 responses mainly restricted at the T cell level. In this study, the homology of the p33 sequence between the clonally imprinted response and the vaccine allele determines the magnitude of vaccine induced responses. C1 [Bergmann-Leitner, Elke S.; Duncan, Elizabeth H.; Mease, Ryan M.; Angov, Evelina] Walter Reed Army Inst Res, US Mil Malaria Vaccine Program, Malaria Vaccine Branch, Silver Spring, MD 20910 USA. RP Bergmann-Leitner, ES (reprint author), Walter Reed Army Inst Res, US Mil Malaria Vaccine Program, Malaria Vaccine Branch, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM Elke.BergmannLeitner@us.army.mil; Evelina.Angov@us.army.mil RI Bergmann-Leitner, Elke/B-3548-2011 OI Bergmann-Leitner, Elke/0000-0002-8571-8956 FU U.S. Agency for International Development [9363118, GHA-T-00-08-00007-01]; United States Army Medical Research and Materiel Command FX The authors thank Kari Laquer and Lily Raines for their technical contributions to the ELISAs and Luminex assays. This work was supported by the U.S. Agency for International Development under project number 9363118, award number GHA-T-00-08-00007-01, and by the United States Army Medical Research and Materiel Command. NR 56 TC 3 Z9 3 U1 0 U2 1 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1475-2875 J9 MALARIA J JI Malar. J. PD SEP 7 PY 2012 VL 11 AR 315 DI 10.1186/1475-2875-11-315 PG 15 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA 043WD UT WOS:000311580400001 PM 22958482 ER PT J AU Lin, HY Causey, R Garcia, GE Snider, BB AF Lin, Hong-Yu Causey, Robert Garcia, Gregory E. Snider, Barry B. TI Synthesis of (+/-)-7-Hydroxylycopodine SO JOURNAL OF ORGANIC CHEMISTRY LA English DT Article ID STRAINED DOUBLE-BONDS; EFFICIENT TOTAL-SYNTHESIS; LYCOPODIUM ALKALOIDS; ALZHEIMERS-DISEASE; HUPERZIA-SAURURUS; METHYLTHIOMETHYL ETHERS; CARBONYL-COMPOUNDS; HYDROXYL-GROUPS; DL-LYCOPODINE; CYCLIZATION AB A seven-step synthesis of (+/-)-7-hydroxylycopodine that proceeds in 5% overall yield has been achieved. The key step is a Prins reaction in 60% sulfuric acid that gave the key tricyclic intermediate with complete control of the ring fusion stereochemistry. A one-pot procedure orthogonally protected the primary alcohol as an acetate and the tertiary alcohol as a methylthiomethyl ether. The resulting product was converted to 7-hydroxydehydrolycopodine by heating with KO-t-Bu and benzophenone in benzene followed by acidic workup. During unsuccessful attempts to make optic:ally pure starting material, we observed the selective Pt-catalyzed hydrogenation of the 5-phenyl group of a 4,5-diphenyloxazolidine under acidic conditions and the Pt-catalyzed isomerization of the oxazolidine to an amide under neutral conditions. In attempts to hydroxylate the starting material so that we could adapt this synthesis to the preparation of (+/-)-7,8-dihydroxylycopodine (sauroine) we observed the novel oxidation of a bicyclic vinylogous amide to a keto pyridine with Mn(OAc)(3) and to an amino phenol with KHMDS and oxygen. C1 [Lin, Hong-Yu; Snider, Barry B.] Brandeis Univ, Dept Chem MS 015, Waltham, MA 02454 USA. [Causey, Robert; Garcia, Gregory E.] USA, Div Res, Physiol & Immunol Branch, Med Res Inst Chem Def,Edgewood Area, Aberdeen Proving Ground, MD 21010 USA. RP Snider, BB (reprint author), Brandeis Univ, Dept Chem MS 015, Waltham, MA 02454 USA. EM snider@brandeis.edu RI Snider, Barry/K-2477-2012 FU National Institutes of Health [GM-50151] FX We are grateful to the National Institutes of Health (GM-50151) for support of this work. We thank Dr. C.-H. Tan, Shanghai Institute of Materia Medica, for a copy of his Ph.D. thesis containing an HMQC spectrum of 7-hydroxylycopodine (5). We thank Mr. Edward P. Dougherty for preparing the cover art and Prof. Chang-Heng Tan, Shanghai Institute of Materia Medica, for a photograph of Huperzia serrata. NR 91 TC 16 Z9 16 U1 2 U2 28 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0022-3263 J9 J ORG CHEM JI J. Org. Chem. PD SEP 7 PY 2012 VL 77 IS 17 BP 7143 EP 7156 DI 10.1021/jo300353t PG 14 WC Chemistry, Organic SC Chemistry GA 000MJ UT WOS:000308390100002 PM 22443298 ER PT J AU Dumas, LJ O'Bleness, MS Davis, JM Dickens, CM Anderson, N Keeney, JG Jackson, J Sikela, M Raznahan, A Giedd, J Rapoport, J Nagamani, SSC Erez, A Brunetti-Pierri, N Sugalski, R Lupski, JR Fingerlin, T Cheung, SW Sikela, JM AF Dumas, Laura J. O'Bleness, Majesta S. Davis, Jonathan M. Dickens, C. Michael Anderson, Nathan Keeney, J. G. Jackson, Jay Sikela, Megan Raznahan, Armin Giedd, Jay Rapoport, Judith Nagamani, Sandesh S. C. Erez, Ayelet Brunetti-Pierri, Nicola Sugalski, Rachel Lupski, James R. Fingerlin, Tasha Cheung, Sau Wai Sikela, James M. TI DUF1220-Domain Copy Number Implicated in Human Brain-Size Pathology and Evolution SO AMERICAN JOURNAL OF HUMAN GENETICS LA English DT Article ID PRIMATE EVOLUTION; GENE; REARRANGEMENTS; DUPLICATIONS; 1Q21.1; EVI5 AB DUF1220 domains show the largest human-lineage-specific increase in copy number of any protein-coding region in the human genome and map primarily to 1q21, where deletions and reciprocal duplications have been associated with microcephaly and macrocephaly, respectively. Given these findings and the high correlation between DUF1220 copy number and brain size across primate lineages (R-2 = 0.98; p = 1.8 x 10(-6)), DUF1220 sequences represent plausible candidates for underlying 1q21-associated brain-size pathologies. To investigate this possibility, we used specialized bioinformatics tools developed for scoring highly duplicated DUF1220 sequences to implement targeted 1q21 array comparative genomic hybridization on individuals (n = 42) with 1q21-associated microcephaly and macrocephaly. We show that of all the 1q21 genes examined (n = 53), DUF1220 copy number shows the strongest association with brain size among individuals with 1q21-associated microcephaly, particularly with respect to the three evolutionarily conserved DUF1220 clades CON1(p = 0.0079), CON2 (p = 0.0134), and CON3 (p = 0.0116). Interestingly, all 1q21 DUF1220-encoding genes belonging to the NBPF family show significant correlations with frontal-occipital-circumference Z scores in the deletion group. In a similar survey of a nondisease population, we show that DUF1220 copy number exhibits the strongest correlation with brain gray-matter volume (CON1, p = 0.0246; and CON2, p = 0.0334). Notably, only DUF1220 sequences are consistently significant in both disease and nondisease populations. Taken together, these data strongly implicate the loss of DUF1220 copy number in the etiology of 1q21-associated microcephaly and support the view that DUF1220 domains function as general effectors of evolutionary, pathological, and normal variation in brain size. C1 [Dumas, Laura J.; O'Bleness, Majesta S.; Davis, Jonathan M.; Dickens, C. Michael; Anderson, Nathan; Keeney, J. G.; Jackson, Jay; Sikela, Megan; Sikela, James M.] Univ Colorado, Sch Med, Dept Biochem & Mol Genet, Aurora, CO 80045 USA. [Dumas, Laura J.; O'Bleness, Majesta S.; Davis, Jonathan M.; Dickens, C. Michael; Anderson, Nathan; Keeney, J. G.; Jackson, Jay; Sikela, Megan; Sikela, James M.] Univ Colorado, Sch Med, Human Med Genet Program, Aurora, CO 80045 USA. [Dumas, Laura J.; O'Bleness, Majesta S.; Davis, Jonathan M.; Dickens, C. Michael; Anderson, Nathan; Keeney, J. G.; Jackson, Jay; Sikela, Megan; Sikela, James M.] Univ Colorado, Sch Med, Neurosci Program, Aurora, CO 80045 USA. [Davis, Jonathan M.; Fingerlin, Tasha] Univ Colorado, Sch Publ Hlth, Dept Epidemiol, Aurora, CO 80045 USA. [Raznahan, Armin; Giedd, Jay; Rapoport, Judith] NIMH, NIH, Bethesda, MD 20892 USA. [Nagamani, Sandesh S. C.; Erez, Ayelet; Lupski, James R.; Cheung, Sau Wai] Baylor Coll Med, Dept Mol & Human Genet, Houston, TX 77030 USA. [Brunetti-Pierri, Nicola] Telethon Inst Genet & Med, I-80131 Naples, Italy. [Brunetti-Pierri, Nicola] Univ Naples Federico II, Dept Pediat, I-80131 Naples, Italy. [Sugalski, Rachel] Brooke Army Med Ctr, San Antonio, TX 78234 USA. RP Sikela, JM (reprint author), Univ Colorado, Sch Med, Dept Biochem & Mol Genet, Aurora, CO 80045 USA. EM james.sikela@ucdenver.edu RI Raznahan, Armin/F-4534-2012; Giedd, Jay/B-7302-2012; Giedd, Jay/J-9644-2015; Brunetti-Pierri, Nicola/K-8465-2016 OI Giedd, Jay/0000-0003-0827-3460; Giedd, Jay/0000-0003-2002-8978; Brunetti-Pierri, Nicola/0000-0002-6895-8819 FU National Institutes of Health (NIH) [R01 MH081203-1, R01 AA11853-11]; Butcher Foundation; JFK Partners, University of Colorado; Maternal Child Health Bureau; Leadership Education in Neurodevelopmental Disabilities grant [T73MC11044]; National Institute on Alcohol Abuse and Alcoholism/National Institute on Drug Abuse [5T32AA007464-32]; American Recovery and Reinvestment Act grant [R01 AA011853-12S1]; NIH Computational Bioscience Program Training Grant [5T15 LM009451-05]; National Institute of Mental Health [R01 MH0811203-02S1]; Coleman Institute for Cognitive Disabilities; Fondazione Telethon FX We thank Pawel Stankiewicz, Martin Kennedy, John Hokanson, and Mark Johnston for helpful comments; Scott Vacha and Amir Ben-Dor for help with aCGH analyses; Andrew Fortna for programming expertise; Gunter Scherer and Elaine Spector for blood draws and DNA isolations; and Jake Saunders for graphics help. We also thank Oxford Gene Technology for high-quality aCGH services. This work was supported by National Institutes of Health (NIH) grants R01 MH081203-1 and R01 AA11853-11 to J.M.S. and a Butcher Foundation grant to J.M.S. and T.F. J.D. was supported in part by JFK Partners, University of Colorado funding from the Maternal Child Health Bureau, and Leadership Education in Neurodevelopmental Disabilities grant T73MC11044. M.O. was supported by a postdoctoral fellowship from the National Institute on Alcohol Abuse and Alcoholism/National Institute on Drug Abuse (5T32AA007464-32). C.M.D. was supported by American Recovery and Reinvestment Act grant R01 AA011853-12S1 and by an NIH Computational Bioscience Program Training Grant (5T15 LM009451-05). N.A. was supported by National Institute of Mental Health Supplementary Grant R01 MH0811203-02S1; J.K. was supported in part through a Graduate Assistantship from the Coleman Institute for Cognitive Disabilities. J.M.S. is a founder and shareholder of GATC Science. J.R.L. is a consultant for Athena Diagnostics, holds stock ownership of 23andMe and Ion Torrent Systems, and is a coinventor on multiple United States and European patents for DNA diagnostics. The Baylor College of Medicine and Department of Molecular and Human Genetics derive revenue from molecular genetics testing clinical services provided by the Medical Genetics Laboratories (https://www.bcm.edu/geneticlabs). NR 17 TC 36 Z9 36 U1 3 U2 21 PU CELL PRESS PI CAMBRIDGE PA 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA SN 0002-9297 J9 AM J HUM GENET JI Am. J. Hum. Genet. PD SEP 7 PY 2012 VL 91 IS 3 BP 444 EP 454 DI 10.1016/j.ajhg.2012.07.016 PG 11 WC Genetics & Heredity SC Genetics & Heredity GA 004LL UT WOS:000308683100005 PM 22901949 ER PT J AU Izvekov, S Rice, BM AF Izvekov, Sergei Rice, Betsy M. TI Free-energy based pair-additive potentials for bulk Ni-Al systems: Application to study Ni-Al reactive alloying SO JOURNAL OF CHEMICAL PHYSICS LA English DT Article ID DENSITY-FUNCTIONAL THEORY; EMBEDDED-ATOM-METHOD; MOLECULAR-DYNAMICS; BIOMOLECULAR SYSTEMS; LIQUID ALUMINUM; SURFACE-TENSION; POINT-DEFECTS; METALS; SIMULATION; DIFFUSION AB We present new numerical pair-additive Al, Ni, and Al-Ni potentials by force-matching (FM) ionic force and virial data from single (bulk liquid) phase ab initio molecular dynamics (MD) simulations using the Born-Oppenheimer method. The potentials are represented by piece-wise functions (splines) and, therefore, are not constrained to a particular choice of analytical functional form. The FM method with virial constraint naturally yields a potential which maps out the ionic free-energy surface of the reference ensemble. To further improve the free energetics of the FM ensemble, the FM procedure is modified to bias the potentials to reproduce the experimental melting temperatures of the reference (FCC-Al, FCC-Ni, B2-NiAl) phases, the only macroscopic data included in the fitting set. The performance of the resultant potentials in simulating bulk metallic phases is then evaluated. The new model is applied to perform MD simulations of self-propagating exothermic reaction in Ni-Al bilayers at P = 0-5 GPa initiated at T = 1300 K. Consistent with experimental observations, the new model describes realistically a sequence of peritectic phase transformations throughout the reaction and at a realistic rate. The reaction proceeds through interlayer diffusion of Al and Ni atoms at the interface with formation of B2-NiAl in the Al melt. Such material responses have, in the past, been proven to be difficult to observe with then-existing potentials. [http://dx.doi.org/10.1063/1.4747546] C1 [Izvekov, Sergei; Rice, Betsy M.] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Izvekov, S (reprint author), USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. FU DoD High Performance Computing Modernization Program Software Application Institute for Multi-Scale Reactive Modeling of Insensitive Munitions FX The authors wish to thank Dr. John Brennan, Dr. Scott Weingarten, and Ms. Sarah Hamdan for helpful comments. This research was supported by the DoD High Performance Computing Modernization Program Software Application Institute for Multi-Scale Reactive Modeling of Insensitive Munitions. Computing support was provided by the DoD Super-computer Resource Center. NR 93 TC 7 Z9 7 U1 1 U2 60 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0021-9606 J9 J CHEM PHYS JI J. Chem. Phys. PD SEP 7 PY 2012 VL 137 IS 9 AR 094704 DI 10.1063/1.4747546 PG 14 WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical SC Chemistry; Physics GA 010JZ UT WOS:000309092000043 PM 22957583 ER PT J AU Whitworth, WC Hamilton, LR Goodwin, DJ Barrera, C West, KB Racster, L Daniels, LJ Chuke, SO Campbell, BH Bohanon, J Jaffar, AT Drane, W Maserang, D Mazurek, GH AF Whitworth, William C. Hamilton, Lanette R. Goodwin, Donald J. Barrera, Carlos West, Kevin B. Racster, Laura Daniels, Laura J. Chuke, Stella O. Campbell, Brandon H. Bohanon, Jamaria Jaffar, Atheer T. Drane, Wanzer Maserang, David Mazurek, Gerald H. TI Within-Subject Interlaboratory Variability of QuantiFERON-TB Gold In-Tube Tests SO PLOS ONE LA English DT Article ID HEALTH-CARE WORKERS; LATENT TUBERCULOSIS INFECTION; INTERFERON-GAMMA RESPONSES; MYCOBACTERIUM-TUBERCULOSIS; PULMONARY TUBERCULOSIS; RELEASE ASSAYS; REPRODUCIBILITY; CONVERSIONS; GUIDELINES; AGREEMENT AB Background: The QuantiFERON (R)-TB Gold In-Tube test (QFT-GIT) is a viable alternative to the tuberculin skin test (TST) for detecting Mycobacterium tuberculosis infection. However, within-subject variability may limit test utility. To assess variability, we compared results from the same subjects when QFT-GIT enzyme-linked immunosorbent assays (ELISAs) were performed in different laboratories. Methods: Subjects were recruited at two sites and blood was tested in three labs. Two labs used the same type of automated ELISA workstation, 8-point calibration curves, and electronic data transfer. The third lab used a different automated ELISA workstation, 4-point calibration curves, and manual data entry. Variability was assessed by interpretation agreement and comparison of interferon-gamma (IFN-gamma) measurements. Data for subjects with discordant interpretations or discrepancies in TB Response >0.05 IU/mL were verified or corrected, and variability was reassessed using a reconciled dataset. Results: Ninety-seven subjects had results from three labs. Eleven (11.3%) had discordant interpretations and 72 (74.2%) had discrepancies >0.05 IU/mL using unreconciled results. After correction of manual data entry errors for 9 subjects, and exclusion of 6 subjects due to methodological errors, 7 (7.7%) subjects were discordant. Of these, 6 (85.7%) had all TB Responses within 0.25 IU/mL of the manufacturer's recommended cutoff. Non-uniform error of measurement was observed, with greater variation in higher IFN-gamma measurements. Within-subject standard deviation for TB Response was as high as 0.16 IU/mL, and limits of agreement ranged from -0.46 to 0.43 IU/mL for subjects with mean TB Response within 0.25 IU/mL of the cutoff. Conclusion: Greater interlaboratory variability was associated with manual data entry and higher IFN-gamma measurements. Manual data entry should be avoided. Because variability in measuring TB Response may affect interpretation, especially near the cutoff, consideration should be given to developing a range of values near the cutoff to be interpreted as "borderline," rather than negative or positive. C1 [Whitworth, William C.; Daniels, Laura J.; Chuke, Stella O.; Campbell, Brandon H.; Mazurek, Gerald H.] Ctr Dis Control & Prevent, Div TB Eliminat, Atlanta, GA 30333 USA. [Hamilton, Lanette R.; Barrera, Carlos] Tripler Army Med Ctr, Dept Med, Honolulu, HI 96859 USA. [Goodwin, Donald J.; Racster, Laura; Bohanon, Jamaria; Jaffar, Atheer T.] USAF, Sch Aerosp Med, Epidemiol Serv Branch, Brooks City Base, TX USA. [West, Kevin B.] Wilford Hall USAF Med Ctr, Reid Clin, Dept Occupat Med TB Prevent Deployment Med, Lackland AFB, TX 78236 USA. [Daniels, Laura J.; Bohanon, Jamaria; Jaffar, Atheer T.] CDC Fdn, Atlanta, GA USA. [Chuke, Stella O.] Northrop Grumman Informat Syst Sect, Atlanta, GA USA. [Drane, Wanzer] Univ S Carolina, Columbia, SC 29208 USA. [Maserang, David] USAF, Sch Aerosp Med, Appl Technol Ctr, Brooks City Base, TX USA. RP Whitworth, WC (reprint author), Ctr Dis Control & Prevent, Div TB Eliminat, Atlanta, GA 30333 USA. EM wcw2@cdc.gov FU United States Air Force (USAF) FX The United States Air Force (USAF) funded this study as part of a larger project assessing reproducibility of the QuantiFERON-TB Gold In-Tube tests. The USAF and the Centers for Disease Control and Prevention (CDC) reviewed the study design, data collection methods, and analysis plans prior to approval. The USAF, U. S. Army, and CDC cleared the manuscript for publication according to established guidelines. No outside funders had a role in the study design, data collection, analysis, decision to publish, or preparation of the manuscript. NR 34 TC 15 Z9 16 U1 0 U2 6 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD SEP 6 PY 2012 VL 7 IS 9 AR e43790 DI 10.1371/journal.pone.0043790 PG 10 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 001KC UT WOS:000308458400019 PM 22970142 ER PT J AU Kennedy, AJ Johnson, DR Seiter, JM Lindsay, JH Boyd, RE Bednar, AJ Allison, PG AF Kennedy, Alan J. Johnson, David R. Seiter, Jennifer M. Lindsay, James H. Boyd, Robert E. Bednar, Anthony J. Allison, Paul G. TI Tungsten Toxicity, Bioaccumulation, and Compartmentalization into Organisms Representing Two Trophic Levels SO ENVIRONMENTAL SCIENCE & TECHNOLOGY LA English DT Article ID HELIX-ASPERSA; SOIL; EARTHWORM; ANIMALS; SNAILS AB Metallic tungsten has civil and military applications and was considered a green alternative to lead. Recent reports of contamination in drinking water and soil have raised scrutiny and suspended some applications. This investigation employed the cabbage Brassica oleracae and snail Otala lactea as models to determine the toxicological implications of sodium tungstate and an aged tungsten powder-spiked soil containing monomeric and polymeric tungstates. Aged soil bioassays indicated cabbage growth was impaired at 436 mg of W/kg, while snail survival was not impacted up to 3793 mg of W/kg. In a dermal exposure, sodium tungstate was more toxic to the snail, with a lethal median concentration of 859 mg of W/kg. While the snail significantly bioaccumulated tungsten, predominately in the hepatopancreas, cabbage leaves bioaccumulated much higher concentrations. Synchrotron-based mapping indicated the highest levels of W were in the veins of cabbage leaves. Our results suggest snails consuming contaminated cabbage accumulated higher tungsten concentrations relative to the concentrations directly bioaccumulated from soil, indicating the importance of robust trophic transfer investigations. Finally, synchrotron mapping provided evidence of tungsten in the inner layer of the snail shell, suggesting potential use of snail shells as a biomonitoring tool for metal contamination. C1 [Kennedy, Alan J.; Johnson, David R.; Seiter, Jennifer M.; Lindsay, James H.; Boyd, Robert E.; Bednar, Anthony J.; Allison, Paul G.] USA, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Kennedy, AJ (reprint author), USA, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. EM Alan.J.Kennedy@usace.army.mil OI Allison, Paul/0000-0002-9041-237X FU Army Environmental Quality Technology Basic Research Program (U.S. Army Engineer Research and Development Center) FX This work was funded by the Army Environmental Quality Technology Basic Research Program (U.S. Army Engineer Research and Development Center, Mr. Martin Savoie and Dr. Elizabeth Ferguson, Technical Directors). Synchrotron analysis was conducted in collaboration with Dr. Sam Webb at the Stanford Synchrotron Radiation Lightsource, a Directorate of the SLAC National Accelerator Laboratory and an Office of Science User Facility operated for the U.S. Department of Energy Office of Science. We appreciate Ashley Harmon for sectioning tissue and constructive comments from Drs. Afrachanna Butler, Chris McGrath, and two anonymous reviewers. Permission was granted by the Chief of Engineers to publish this information. NR 43 TC 8 Z9 9 U1 2 U2 36 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0013-936X J9 ENVIRON SCI TECHNOL JI Environ. Sci. Technol. PD SEP 4 PY 2012 VL 46 IS 17 BP 9646 EP 9652 DI 10.1021/es300606x PG 7 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA 998SM UT WOS:000308260700054 PM 22873780 ER PT J AU Uzarski, JR Mello, CM AF Uzarski, Joshua R. Mello, Charlene M. TI Detection and Classification of Related Lipopolysaccharides via a Small Array of Immobilized Antimicrobial Peptides SO ANALYTICAL CHEMISTRY LA English DT Article ID SELF-ASSEMBLED MONOLAYERS; PROTEIN ADSORPTION; ESCHERICHIA-COLI; RECOGNITION MOLECULES; CONFORMATION; BIOSENSOR; BACTERIAL; GOLD; SPECTROSCOPY; MECHANISMS AB A small array of antimicrobial peptides comprising three cysteine-terminated natural sequences covalently immobilized to pendant surface maleimide groups are used to bind and successfully discriminate five types of lipopolysaccharide (LPS) molecules. Using surface plasmon resonance, LPSs isolated from four strains of Escherichia coli and one strain of Pseudomonas aeruginosa yield distinct binding profiles to the three immobilized peptides. Linear discriminant analysis generated 100% training set and 80% validation set classification success for the 40 samples evaluated. This work demonstrates the discriminatory binding capabilities of immobilized antimicrobial peptides toward LPS molecules and alludes to their use as probes in pathogen sensing devices potentially superior to the current state-of-the-art. C1 [Uzarski, Joshua R.] USA, Natick Solider Res, Ctr Dev & Engn, Natick, MA 01760 USA. Univ Massachusetts Dartmouth, Dept Chem & Biochem, N Dartmouth, MA 02747 USA. RP Uzarski, JR (reprint author), USA, Natick Solider Res, Ctr Dev & Engn, Natick, MA 01760 USA. EM juzarski@umassd.edu; charlene.m.mello2.civ@mail.mil FU U.S. Army Natick Research, Development and Engineering Center In-House Laboratory Independent Research (ILIR) program; DTRA Medical Diagnostics [8.10012_08_NRL_B]; National Research Council CBD postdoctoral fellowship program FX The authors would like to acknowledge Dr. Morris Slutsky for his insightful discussions and generous help with data analysis. This work was supported by the U.S. Army Natick Research, Development and Engineering Center In-House Laboratory Independent Research (ILIR) program, DTRA Medical Diagnostics (8.10012_08_NRL_B) and the National Research Council CBD postdoctoral fellowship program. NR 40 TC 20 Z9 20 U1 1 U2 47 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0003-2700 J9 ANAL CHEM JI Anal. Chem. PD SEP 4 PY 2012 VL 84 IS 17 BP 7359 EP 7366 DI 10.1021/ac300987h PG 8 WC Chemistry, Analytical SC Chemistry GA 998QL UT WOS:000308255400014 PM 22881053 ER PT J AU Paramasivam, A Sambantham, S Shabnam, J Raghunandhakumar, S Anandan, B Rajiv, R Priyadharsini, JV Jayaraman, G AF Paramasivam, Arumugam Sambantham, Shanmugam Shabnam, Jawahar Raghunandhakumar, Subramanian Anandan, Balakrishnan Rajiv, Rose Priyadharsini, Jayaseelan Vijayashree Jayaraman, Gopalswamy TI Anti-cancer effects of thymoquinone in mouse neuroblastoma (Neuro-2a) cells through caspase-3 activation with down-regulation of XIAP SO TOXICOLOGY LETTERS LA English DT Article DE Thymoquinone; Neuroblastoma; Apoptosis; Caspase; XIAP ID COLORECTAL-CANCER CELLS; X-LINKED INHIBITOR; ANTITUMOR-ACTIVITY; NIGELLA-SATIVA; IN-VITRO; BREAST-CANCER; JURKAT CELLS; APOPTOSIS; PATHWAY; CISPLATIN AB Thymoquinone (TQ) is a bioactive component derived from the medicinal plant Nigella sativa. Recent studies reported that TQ exhibited cytotoxic effects in several cancer cell lines. Currently, no information in the literature is found concerning its mechanisms and cytotoxicity on neuroblastoma cells. In this study, the cytotoxicity of TQ in mouse neuroblastoma cells (Neuro-2a) was investigated. Our results showed that TQ significantly reduced viability of Neuro-2a cells than normal neuronal cells. Apoptosis induction by TQ was confirmed by DAPI and AO/PI staining. TQ triggered the apoptotic pathway, which was characterized by increased Bax/Bcl-2 ratio. TQ significantly increased the expression of pro-apoptotic protein Bax, whereas decreased the expression of anti-apoptotic protein Bcl-2, which leads to the release of cytochrome c from mitochondria into the cytoplasm. Moreover, TQ treatment directs the activation of caspase-3 followed by the cleavage of poly(ADP-ribose) polymerase (PARP). Interestingly, we also observed that TQ down-regulated caspase inhibitor X-linked inhibitor of apoptosis protein (XIAP). These results indicate that TQ induces apoptosis via caspase-3 activation with down-regulation of XIAP in Neuro-2a cells. (C) 2012 Elsevier Ireland Ltd. All rights reserved. C1 [Paramasivam, Arumugam; Sambantham, Shanmugam; Shabnam, Jawahar; Anandan, Balakrishnan; Priyadharsini, Jayaseelan Vijayashree; Jayaraman, Gopalswamy] Univ Madras, Dr ALM Post Grad Inst Basic Med Sci, Dept Genet, Madras 600113, Tamil Nadu, India. [Raghunandhakumar, Subramanian] Univ Madras, Dept Biochem, Madras 600025, Tamil Nadu, India. [Rajiv, Rose] USA, Inst Surg Res, Med Res & Mat Command, San Antonio, TX 78234 USA. RP Jayaraman, G (reprint author), Univ Madras, Dr ALM Post Grad Inst Basic Med Sci, Dept Genet, Sekkizhar Campus, Madras 600113, Tamil Nadu, India. EM gjlab2012@gmail.com NR 55 TC 17 Z9 20 U1 2 U2 9 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0378-4274 EI 1879-3169 J9 TOXICOL LETT JI Toxicol. Lett. PD SEP 3 PY 2012 VL 213 IS 2 BP 151 EP 159 DI 10.1016/j.toxlet.2012.06.011 PG 9 WC Toxicology SC Toxicology GA 005SH UT WOS:000308769700003 PM 22732633 ER PT J AU Kiel, JL AF Kiel, John Loran, Jr. TI WAR CRIMES IN THE AMERICAN REVOLUTION: EXAMINING THE CONDUCT OF LT. COL. BANASTRE TARLETON AND THE BRITISH LEGION DURING THE SOUTHERN CAMPAIGNS OF 1780-1781 SO MILITARY LAW REVIEW LA English DT Article ID LAW C1 [Kiel, John Loran, Jr.] US Mil Acad, West Point, NY 10996 USA. RP Kiel, JL (reprint author), USA, Joint Multinatl Training Command, Grafenwoehr, Germany. NR 43 TC 0 Z9 0 U1 0 U2 0 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 USA SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD FAL PY 2012 VL 213 BP 29 EP 64 PG 36 WC Law SC Government & Law GA 120GY UT WOS:000317160000002 ER PT J AU Paschal, MD AF Paschal, Marlin D. TI GETTING BEYOND "GOOD ENOUGH" IN CONTINGENCY CONTRACTING BY USING PUBLIC PROCUREMENT LAW AS A FORCE TO FIGHT CORRUPTION SO MILITARY LAW REVIEW LA English DT Article C1 [Paschal, Marlin D.] 1st Armored Div, Fort Bliss, NM USA. [Paschal, Marlin D.] USA, Legal Serv Agcy, Ft Belvoir, VA USA. [Paschal, Marlin D.] 413th Contract Support Brigade, Ft Shafter, HI USA. NR 116 TC 1 Z9 1 U1 1 U2 3 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 USA SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD FAL PY 2012 VL 213 BP 65 EP 139 PG 75 WC Law SC Government & Law GA 120GY UT WOS:000317160000003 ER PT J AU Stigall, DE AF Stigall, Dan E. TI THE LAW OF ARMED CONFLICT: AN OPERATIONAL APPROACH SO MILITARY LAW REVIEW LA English DT Book Review C1 [Stigall, Dan E.] US Dept Justice, Off Int Affairs, Washington, DC 20530 USA. [Stigall, Dan E.] USA, Judge Advocate Gen Legal Ctr & Sch, Charlottesville, VA USA. [Stigall, Dan E.] US Dept Justice, Washington, DC USA. RP Stigall, DE (reprint author), US Dept Justice, Off Int Affairs, Washington, DC 20530 USA. NR 33 TC 0 Z9 0 U1 0 U2 0 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 USA SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD FAL PY 2012 VL 213 BP 227 EP 241 PG 15 WC Law SC Government & Law GA 120GY UT WOS:000317160000008 ER PT J AU Deyle, GD Gill, NW AF Deyle, Gail D. Gill, Norman W. TI Well-Tolerated Strategies for Managing Knee Osteoarthritis: A Manual Physical Therapist Approach to Activity, Exercise, and Advice SO PHYSICIAN AND SPORTSMEDICINE LA English DT Article DE knee osteoarthritis; physical therapy; exercise; rehabilitation ID CRUCIATE LIGAMENT RECONSTRUCTION; RANDOMIZED CLINICAL-TRIAL; HIP OSTEOARTHRITIS; ACTIVATION FAILURE; OLDER-ADULTS; JOINT INJURY; RISK-FACTORS; REPLACEMENT; PAIN; PREVALENCE AB The orthopedic manual physical therapist approach to knee osteoarthritis (OA) is an effective, well-tolerated, and comprehensive strategy that provides a spectrum of intervention measures, which include guidance on activity selection, as well as selection of manual treatment and exercises to systematically address impairments and increase strength and movement in the knee and other related body regions. This approach integrates manually applied treatment while reinforcing exercise and functional activities that are tailored in scope and dose to each patient. Concepts used in the careful design of this exercise program include emphasizing minimal dosing, avoiding exacerbation, using exercises with multiple effects, effective functional positioning, emphasizing the importance of mid-range movements and end-range challenges, and strategic timing of exercises. Focusing on motion and strength gains through range of motion, along with functional or reinforcing activities, such as walking or biking to maintain motion and strength gains, are keys to long-term success. The overarching theme is that well-tolerated strategies using manual treatment, exercise, and activity require deliberate design and targeting of the most common impairments and functional limitations seen in the knee OA population and, more importantly, tailoring to the individual patient. C1 [Deyle, Gail D.; Gill, Norman W.] Brooke Army Med Ctr, Army Baylor Doctoral Fellowship Program Orthopaed, San Antonio, TX 78218 USA. RP Deyle, GD (reprint author), Brooke Army Med Ctr, Army Baylor Doctoral Fellowship Program Orthopaed, San Antonio, TX 78218 USA. EM gail.deyle@amedd.army.mil NR 70 TC 6 Z9 7 U1 1 U2 10 PU JTE MULTIMEDIA PI BERWYN PA 1235 WESTLAKES DR, STE 220, BERWYN, PA 19312 USA SN 0091-3847 J9 PHYSICIAN SPORTSMED JI Physician Sportsmed. PD SEP PY 2012 VL 40 IS 3 BP 12 EP 25 DI 10.3810/psm.2012.09.1976 PG 14 WC Primary Health Care; Orthopedics; Sport Sciences SC General & Internal Medicine; Orthopedics; Sport Sciences GA 107DZ UT WOS:000316196300001 PM 23528617 ER PT J AU Walk, RD AF Walk, Robert D. TI Chemical Warfare during the Vietnam War: Riot Control Agents in Combat SO JOURNAL OF COLD WAR STUDIES LA English DT Book Review C1 [Walk, Robert D.] USA, San Antonio, TX USA. NR 1 TC 0 Z9 0 U1 3 U2 12 PU MIT PRESS PI CAMBRIDGE PA 55 HAYWARD STREET, CAMBRIDGE, MA 02142 USA SN 1520-3972 J9 J COLD WAR STUD JI J. Cold War Stud. PD FAL PY 2012 VL 14 IS 4 BP 233 EP 234 PG 2 WC History; International Relations; Political Science SC History; International Relations; Government & Law GA 099GZ UT WOS:000315610800016 ER PT J AU Gallagher, SP Thompson, S Wright, DW AF Gallagher, Sean P. Thompson, Shaun Wright, David W. TI Identifying factors limiting coho salmon to inform stream restoration in coastal Northern California SO CALIFORNIA FISH AND GAME LA English DT Article DE California; coho salmon; habitat; Mendocino County; Oncorhynchus kisutch; Oncorhynchus mykiss; Oncorhynchus tshawytscha; restoration; survival ID ONCORHYNCHUS-KISUTCH; SMOLT PRODUCTION; LARGE WOOD; ABUNDANCE; SURVIVAL; INCREASE; HABITAT; TIME AB We evaluated an eleven-year (2000 to 2011) coho salmon adult, parr, and smolt abundance data stream from three census watersheds in coastal Mendocino County, California to determine how this information can provide a scientific basis for directing life-stage specific stream restoration activities. The three census watersheds: Caspar Creek, Pudding Creek, and the South Fork Noyo River called Life Cycle Monitoring Streams (LCMS), are part of the California Coastal Salmonid Monitoring Plan. These LCMS are places where we estimate adult, parr, and smolt abundance; make connections between life stage abundance and abiotic factors; and serve as focal points to foster additional watershed and salmon research. Adult and smolt abundance was estimated using capture-recapture methods where fish were marked with either batch marks or individual identifiers and we estimated parr abundance with depletion sampling. Since 2006, we have applied Passive Integrated Transponder (PIT) tags to parr and smolts >70 mm and used this information to estimate abundance and survival. We used these data to calculate marine and freshwater survival, estimate carrying capacity of the three streams, and investigate the relationship between survival and abiotic factors (stream flow, turbidity, and temperature). We present the findings of this analysis and our results in relation to habitat census evaluations conducted during summer 2011. Finally, we discuss the application of our findings to restoration using large wood, and provide recommendations for future work to increase coho salmon production. C1 [Gallagher, Sean P.; Thompson, Shaun] Calif Dept Fish & Game, Ft Bragg, CA 95437 USA. [Wright, David W.] Campbell Timberlands Management LLC, Ft Bragg, CA 95437 USA. RP Gallagher, SP (reprint author), Calif Dept Fish & Game, 32330 N Harbor Dr, Ft Bragg, CA 95437 USA. EM sgallagh@dfg.ca.gov FU California Department of Fish and Game Fisheries Restoration Grant Program [P0410527, P0510544, P0610540, P0710540, P0810312] FX This work was funded by the California Department of Fish and Game Fisheries Restoration Grant Program (Grants P0410527, P0510544, P0610540, P0710540, and P0810312). Research on live fish followed appropriate guidelines required under the Endangered Species Act Section 10 process (Permit number 10093) and CDFG policies. Many individuals, too numerous to mention by name, from CDFG, CTM, NOAA Fisheries Santa Cruz, and the Pacific States Marine Fisheries Commission helped with this study; be assured we value your help. A few we are compelled to mention specifically include S. Allen for administrative support, W. Holloway for help with Figure 1, E. Lang, and C. Bell for many long hours in the field, and C. Gallagher and J. Ferreira for statistical assistance. D. Albin, V. Bleich, L. Bolton, S. Hayes, D. Porter, K. Shaffer, and an anonymous reviewer provided useful comments that greatly improved the manuscript. NR 36 TC 3 Z9 3 U1 2 U2 31 PU CALIFORNIA FISH AND GAME EDITOR PI SACRAMENTO PA 1416 NINTH ST, SACRAMENTO, CA 95814 USA SN 0008-1078 J9 CALIF FISH GAME JI Calif. Fish Game PD FAL PY 2012 VL 98 IS 4 BP 185 EP 201 PG 17 WC Fisheries; Zoology SC Fisheries; Zoology GA 094FP UT WOS:000315248700002 ER PT J AU Krakauer, T Buckley, M AF Krakauer, Teresa Buckley, Marilyn TI Intranasal Rapamycin Rescues Mice from Staphylococcal Enterotoxin B-Induced Shock SO TOXINS LA English DT Article DE intranasal rapamycin; staphylococcal enterotoxin B; shock ID CLASS-II MOLECULES; TOXIC-SHOCK; LETHAL SHOCK; BACTERIAL SUPERANTIGENS; CYTOKINE RELEASE; T-CELLS; TRANSGENIC MICE; ACTIVATION; MODEL; TEMPERATURE AB Staphylococcal enterotoxin B (SEB) and related exotoxins produced by Staphylococcus aureus are potent activators of the immune system and cause toxic shock in humans. Currently there is no effective treatment except for the use of intravenous immunoglobulins administered shortly after SEB exposure. Intranasal SEB induces long-lasting lung injury which requires prolonged drug treatment. We investigated the effects of rapamycin, an immunosuppressive drug used to prevent graft rejection, by intranasal administration in a lethal mouse model of SEB-induced shock. The results show that intranasal rapamycin alone delivered as late as 17 h after SEB protected 100% of mice from lethal shock. Additionally, rapamycin diminished the weight loss and temperature fluctuations elicited by SEB. Intranasal rapamycin attenuated lung MCP-1, IL-2, IL-6, and IFN gamma by 70%, 30%, 64%, and 68% respectively. Furthermore, short courses (three doses) of rapamycin were sufficient to block SEB-induced shock. Intranasal rapamycin represents a novel use of an immunosuppressant targeting directly to site of toxin exposure, reducing dosages needed and allowing a wider therapeutic window. C1 [Krakauer, Teresa; Buckley, Marilyn] USA, Integrated Toxicol Div, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. RP Krakauer, T (reprint author), USA, Integrated Toxicol Div, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. EM Teresa.krakauer@amedd.army.mil; marilyn.buckley@us.army.mil NR 37 TC 5 Z9 5 U1 0 U2 2 PU MDPI AG PI BASEL PA POSTFACH, CH-4005 BASEL, SWITZERLAND SN 2072-6651 J9 TOXINS JI Toxins PD SEP PY 2012 VL 4 IS 9 BP 718 EP 728 DI 10.3390/toxins4090718 PG 11 WC Toxicology SC Toxicology GA 096LP UT WOS:000315405900006 PM 23105977 ER PT J AU Kolb, CM Pierce, LM Roofe, SB AF Kolb, Caroline M. Pierce, Lisa M. Roofe, Scott B. TI Biocompatibility Comparison of Novel Soft Tissue Implants vs Commonly Used Biomaterials in a Pig Model SO OTOLARYNGOLOGY-HEAD AND NECK SURGERY LA English DT Article DE soft tissue implants; augmentation; bioscaffold; expanded polytetrafluoroethylene; human dermis; porcine dermis ID EXPANDED POLYTETRAFLUOROETHYLENE; FREE-FLAP; AUGMENTATION; RABBIT; TERM; RECONSTRUCTION; INGROWTH; COLLAGEN; SURGERY; FILLERS AB Objective. To develop a model to evaluate biocompatibility, integration, and substrate independence of novel porous bioscaffolds for maxillofacial and plastic reconstruction using sphere-templated angiogenic regeneration technology compared with currently available synthetic and biologic soft tissue implants. Study Design. A prospective pilot study using animals. Setting. Military medical center. Subjects and Methods. Five pigs underwent dorsal subcutaneous implantation of a polypropylene-based material coated with precision pore silicone granules (sphere-templated scaffold), expanded polytetrafluoroethylene, human dermis, and porcine dermis. Sham and undissected sites were also used as controls. Specimens were harvested 7, 21, 90, and 180 days after surgery and evaluated histologically for inflammation, neovascularization, and collagen deposition. Results. All materials and sham sites induced a mild to moderate inflammation that decreased over time, except for human dermis, which elicited a moderate to severe inflammatory response. The responses were varied and measurable using subjective scoring methods. The sphere-templated scaffold demonstrated numerous foreign body giant cells adjacent to the silicone granules, which were not seen in any of the other specimens. Conclusion. Subjective scoring of pathology slides and measurement of capsule thickness appeared to show differences between the materials, but these differences require a larger number of subjects and proper statistical analysis to assess. The robust foreign body reaction elicited by the polypropylene/ silicone-based scaffold argues against the use of this material in future studies. The authors advocate using inert biodegradable substances for future bioscaffold constructs. C1 [Kolb, Caroline M.; Pierce, Lisa M.; Roofe, Scott B.] Tripler Army Med Ctr, Honolulu, HI 96859 USA. RP Kolb, CM (reprint author), Tripler Army Med Ctr, Dept Otolaryngol, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM caroline.m.kolb@us.army.mil FU Tripler Army Medical Center Department of Clinical Investigation FX This study was funded by the Tripler Army Medical Center Department of Clinical Investigation, which provided funding to purchase the graft materials. The STAR implant was donated by Healionics Corporation, but no part of the concept of the study or the results of the study was shared with the company until after presentation. NR 36 TC 5 Z9 5 U1 3 U2 16 PU SAGE PUBLICATIONS LTD PI LONDON PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND SN 0194-5998 J9 OTOLARYNG HEAD NECK JI Otolaryngol. Head Neck Surg. PD SEP PY 2012 VL 147 IS 3 BP 456 EP 461 DI 10.1177/0194599812450855 PG 6 WC Otorhinolaryngology; Surgery SC Otorhinolaryngology; Surgery GA 080YT UT WOS:000314281300009 PM 22687327 ER PT J AU Waetjen, L Parker, M Wilken, JM AF Waetjen, Linda Parker, Matthew Wilken, Jason M. TI The effects of altering initial ground contact in the running gait of an individual with transtibial amputation SO PROSTHETICS AND ORTHOTICS INTERNATIONAL LA English DT Article DE Amputation; running; kinematic; ground reaction force; knee moment ID KNEE-JOINT; OSTEOARTHRITIS; FORCES; IMPACT; AMPUTEES; PATTERNS; WALKING; PAIN AB Background: High rates of osteoarthritis of the knee joint of the intact limb in persons with amputation have raised concern about the long-term consequence of running. The purpose of this intervention was to determine if loading of the knee on the intact limb of a person with transtibial amputation during running could be decreased by changing the intact limb initial ground contact from rear foot to forefoot strike. Case Description and Methods: This study compared kinematic, kinetic and temporal-spatial data collected while a 27-year-old male, who sustained a traumatic unilateral transtibial amputation of the left lower extremity, ran using a forefoot ground contact and again while using a heel first ground contact. Findings and Outcomes: Changing initial ground contact from rear foot strike to forefoot strike resulted in decreases in vertical ground reaction forces at impact, peak knee moments in stance, peak knee powers, and improved symmetry in step length. Conclusion: This case suggests forefoot initial contact of the intact limb may minimize loading of the knee on the intact limb in individuals with transtibial amputation. C1 [Waetjen, Linda; Parker, Matthew; Wilken, Jason M.] Brooke Army Med Ctr, Ctr Intrepid, Ft Sam Houston, TX 78234 USA. RP Waetjen, L (reprint author), Brooke Army Med Ctr, Ctr Intrepid, 3551 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM linda.waetjen@gmail.com OI Wilken, Jason/0000-0002-5556-7667 FU Military Amputee Research Program FX Support provided by the Military Amputee Research Program. NR 15 TC 3 Z9 3 U1 0 U2 16 PU SAGE PUBLICATIONS LTD PI LONDON PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND SN 0309-3646 J9 PROSTHET ORTHOT INT JI Prosthet. Orthot. Int. PD SEP PY 2012 VL 36 IS 3 SI SI BP 356 EP 360 DI 10.1177/0309364611433353 PG 5 WC Orthopedics; Rehabilitation SC Orthopedics; Rehabilitation GA 080LV UT WOS:000314244900014 PM 22918914 ER PT J AU Krawczyk, S AF Krawczyk, Scott TI Organising Poetry: The Coleridge Circle, 1790-1798 SO STUDIES IN ROMANTICISM LA English DT Book Review C1 [Krawczyk, Scott] US Mil Acad, West Point, NY 10996 USA. RP Krawczyk, S (reprint author), US Mil Acad, West Point, NY 10996 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU BOSTON UNIV SCHOLARLY PUBL PI BOSTON PA 985 COMMONWEALTH AVE, BOSTON, MA 02215 USA SN 0039-3762 J9 STUD ROMANTICISM JI Stud. Romant. PD FAL PY 2012 VL 51 IS 3 BP 455 EP 460 PG 6 WC Literature SC Literature GA 071NS UT WOS:000313602100008 ER PT J AU Nation, RC AF Nation, R. Craig TI Reset or rerun? Sources of discord in Russian-American relations SO COMMUNIST AND POST-COMMUNIST STUDIES LA English DT Article DE Five-Day War; Reset agenda; Vladimir Putin; Energy security; Authoritarian governance; New Start Treaty; Missile defense; Counter-proliferation; Sphere of privileged interests; Shanghai Cooperation Organization AB Despite some notable accomplishments, the effort underway since 2008 to "reset" U.S.-Russian relations on a foundation of mutual interests is far from secure. In the past the Russian Federation and the U.S. have moved through a number of cycles where phases of rapprochement have given way to intensified strategic competition. This pattern could reproduce itself if a momentum of expanded cooperation is not sustained. Today, in critical areas such as democratization and respect for human rights, arms control, counter proliferation, energy security, and regional stability, conflict is becoming more pronounced. If the reset agenda is to lead forward to a more substantial redefinition of the U.S.-Russian relationship these underlying sources of conflict will need to be addressed. For the promise of rapprochement to be realized the U.S. and its allies must look beyond the limited goals of the reset as originally defined towards a strategy of more comprehensive engagement designed to bring Russia into the fold as a cooperative member of the Western security community. Published by Elsevier Ltd on behalf of The Regents of the University of California. C1 USA, War Coll, Carlisle, PA USA. RP Nation, RC (reprint author), USA, War Coll, Carlisle, PA USA. NR 88 TC 0 Z9 0 U1 3 U2 15 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0967-067X J9 COMMUNIS POST-COMMUN JI Communist Post-Communist Stud. PD SEP-DEC PY 2012 VL 45 IS 3-4 SI SI BP 379 EP 387 DI 10.1016/j.postcomstud.2012.07.011 PG 9 WC International Relations; Political Science SC International Relations; Government & Law GA 068QG UT WOS:000313380700019 ER PT J AU Helwig, BG Ward, JA Blaha, MD Leon, LR AF Helwig, Bryan G. Ward, Jermaine A. Blaha, Michael D. Leon, Lisa R. TI Effect of Intraperitoneal Radiotelemetry Instrumentation on Voluntary Wheel Running and Surgical Recovery in Mice SO JOURNAL OF THE AMERICAN ASSOCIATION FOR LABORATORY ANIMAL SCIENCE LA English DT Article ID TRANSMITTER IMPLANTATION; EXERCISE; MOUSE; LIPOPOLYSACCHARIDE; MODELS AB Radiotelemetry transmitters support tracking of physiologic variables in conscious animals, but the size of the transmitter may alter animal health and behavior. We hypothesized that the size of the device adversely affects body weight, food intake, water intake, circadian core temperature, activity, voluntary running patterns, and the health of internal organs and that these negative effects can be minimized with smaller transmitter devices. Male C57BL/6J mice (weight, 20 to 24 g) were implanted with small (1.1 g, 0.52 mL) or large (3.5 g, 1.75 mL) radiotransmitters. Recovery of presurgical body weight, food intake, and water intake occurred within 3 d in mice implanted with small transmitter and 9 d in those with large transmitters. Mice with small transmitters displayed robust circadian core body temperature and activity patterns within 1 d after surgery, whereas activity was depressed in mice with large transmitters throughout experimentation. The most robust effects of the large transmitter included significantly reduced voluntary running, which never recovered to baseline, and inflammation of the diaphragm, large intestine, and duodenum. These results demonstrate that the large transmitter delayed surgical recovery, disrupted normal growth, reduced voluntary running, and induced inflammatory reactions of the internal organs of mice. The choice of radiotelemetry transmitter can significantly affect the health and wellbeing of experimental mice as well as data quality, such that the smallest transmitter device available and appropriate to the situation should be chosen for experimentation. C1 [Helwig, Bryan G.; Ward, Jermaine A.; Blaha, Michael D.; Leon, Lisa R.] USA, Environm Med Res Inst, Thermal Mt Med Div, Natick, MA 01760 USA. RP Helwig, BG (reprint author), USA, Environm Med Res Inst, Thermal Mt Med Div, Natick, MA 01760 USA. EM bryan.helwig@us.army.mil FU US Army Medical Research and Materiel Command FX Research funded by US Army Medical Research and Materiel Command. Approved for public release, distribution is unlimited. The opinions or assertions contained herein are the private views of the author(s) and are not to be construed as official or reflecting the views of the Army or the Department of Defense. Any citations of commercial organizations and trade names in this report do not constitute an official Department of the Army endorsement of approval of the products or services of these organizations. NR 18 TC 5 Z9 5 U1 0 U2 3 PU AMER ASSOC LABORATORY ANIMAL SCIENCE PI MEMPHIS PA 9190 CRESTWYN HILLS DR, MEMPHIS, TN 38125 USA SN 1559-6109 J9 J AM ASSOC LAB ANIM JI J. Amer. Assoc. Lab. Anim. Sci. PD SEP PY 2012 VL 51 IS 5 BP 600 EP 608 PG 9 WC Veterinary Sciences; Zoology SC Veterinary Sciences; Zoology GA 067NV UT WOS:000313303300010 PM 23312089 ER PT J AU Rodriguez, M Luthra, R Slaughter, T Elster, E Crane, N AF Rodriguez, M. Luthra, R. Slaughter, T. Elster, E. Crane, N. TI Understanding Systemic Responses to Localized Limb Ischemia-Reperfusion Injury: A Yorkshire Swine Model SO JOURNAL OF THE AMERICAN ASSOCIATION FOR LABORATORY ANIMAL SCIENCE LA English DT Meeting Abstract C1 [Rodriguez, M.; Luthra, R.; Elster, E.; Crane, N.] NMRC, Dept Regenerat Med, Silver Spring, MD USA. [Slaughter, T.] Uniformed Serv Univ Hlth Sci, Dept Surg, Bethesda, MD 20814 USA. [Elster, E.] Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU AMER ASSOC LABORATORY ANIMAL SCIENCE PI MEMPHIS PA 9190 CRESTWYN HILLS DR, MEMPHIS, TN 38125 USA SN 1559-6109 J9 J AM ASSOC LAB ANIM JI J. Amer. Assoc. Lab. Anim. Sci. PD SEP PY 2012 VL 51 IS 5 BP 700 EP 701 PG 2 WC Veterinary Sciences; Zoology SC Veterinary Sciences; Zoology GA 067NV UT WOS:000313303300295 ER PT J AU McCown, ME Monterroso, VH Cardona, W AF McCown, M. E. Monterroso, V. H. Cardona, W. TI Surveillance for Ehrlichia canis, Anaplasma phagocytophilum, Borrelia burgdorferi, and Dirofilaria immitis in Dogs from 3 Cities in Colombia SO JOURNAL OF THE AMERICAN ASSOCIATION FOR LABORATORY ANIMAL SCIENCE LA English DT Meeting Abstract C1 [McCown, M. E.] USA, Vet Corps, Ft Sam Houston, TX USA. [Monterroso, V. H.] Oregon Hlth & Sci Univ, Portland, OR 97201 USA. [Cardona, W.] Carval, Medellin, Colombia. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC LABORATORY ANIMAL SCIENCE PI MEMPHIS PA 9190 CRESTWYN HILLS DR, MEMPHIS, TN 38125 USA SN 1559-6109 J9 J AM ASSOC LAB ANIM JI J. Amer. Assoc. Lab. Anim. Sci. PD SEP PY 2012 VL 51 IS 5 BP 708 EP 708 PG 1 WC Veterinary Sciences; Zoology SC Veterinary Sciences; Zoology GA 067NV UT WOS:000313303300324 ER PT J AU Sarker, BR Baylot, EA AF Sarker, Bhaba R. Baylot, E. Alex TI Throughput Capacity Estimation for Convoy Movement in Linked Roads SO JOURNAL OF TRANSPORTATION ENGINEERING-ASCE LA English DT Article DE Turning speed; Delay time; Arc throughput rate; Linked roads ID TRAFFIC FLOW; NETWORK; INTERSECTION; URBAN; DERIVATION; MODELS; DELAYS; SPEED; PATH AB This research is aimed at finding the throughput rate of convoy movement in a transportation network. The primary goal of the study is first to find the throughput rate that will facilitate an estimate of the time to logistically deploy one unit, omnidirectionally (radially), to different localities during different elapsed times. The concept of average speed on a linked road is used to estimate the throughput rate of the vehicles. Several models for physical boundary conditions have been established to estimate the turning delay time in a convoy movement through streets in an urban environment under different conditions of road geometry. Special cases are also evaluated to study the capability of the general models. As a primary emphasis of the study, delay time at a turning is modeled to estimate the individual arc capacity and linked-arcs capacity. A model to estimate the average velocity in a linked road is developed to determine the average throughput rate of a route for a convoy movement. In all modeling approaches, detailed descriptions of the derivations are illustrated with numerical examples and figures. DOI: 10.1061/(ASCE)TE.1943-5436.0000421. (C) 2012 American Society of Civil Engineers. C1 [Sarker, Bhaba R.] Louisiana State Univ, Dept Construct Management & Ind Engn, Baton Rouge, LA 70803 USA. [Baylot, E. Alex] USAC Engineer Res & Dev Ctr, Mobil Syst Branch, Engn Syst & Mat Div, Vicksburg, MS 39180 USA. RP Sarker, BR (reprint author), Louisiana State Univ, Dept Construct Management & Ind Engn, Baton Rouge, LA 70803 USA. EM bsarker@lsu.edu; alex.baylot@usace.army.mil FU USACE under the SFFP [DAAD19-02-D-0001, TCN: 04-043, 0394] FX The authors are thankful to the three anonymous reviewers for their critical comments and constructive suggestions, the responses to which improved the quality and presentation of the paper significantly. This research was funded by the USACE under the SFFP Contract #DAAD19-02-D-0001, TCN: 04-043 (Delivery Order: 0394). NR 49 TC 1 Z9 1 U1 1 U2 10 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 0733-947X J9 J TRANSP ENG-ASCE JI J. Transp. Eng.-ASCE PD SEP PY 2012 VL 138 IS 9 BP 1133 EP 1142 DI 10.1061/(ASCE)TE.1943-5436.0000421 PG 10 WC Engineering, Civil; Transportation Science & Technology SC Engineering; Transportation GA 060HP UT WOS:000312767400006 ER PT J AU Blaylock, JM Wortmann, GW AF Blaylock, Jason M. Wortmann, Glenn W. TI A case report and literature review of "Chiclero's ulcer" SO TRAVEL MEDICINE AND INFECTIOUS DISEASE LA English DT Article DE Chiclero's ulcer; Cutaneous leishmaniasis; Leishmania mexicana ID WORLD CUTANEOUS LEISHMANIASIS; YUCATAN PENINSULA; CLINICAL-ASPECTS; MEXICO; EPIDEMIOLOGY; DIAGNOSIS; CAMPECHE; STATE; TEXAS AB An 86-year-old man with history of travel to Guatemala presented with a 4-month history of an enlarging ulcerative lesion on his right ear. After several weeks of empiric treatment for otitis externa, histopathology, culture, and PCR analysis of a biopsy specimen confirmed the diagnosis of localized cutaneous leishmaniasis secondary to Leishmania mexicana. Known as "Chiclero's ulcer" in southeast Mexico and Latin America, this unique presentation of cutaneous leishmaniasis is caused mainly by the L. mexicana complex. Infection results in a single ulcerative lesion, most commonly involving the ear pinna, without a tendency for cutaneous metastasis, lymphatic or mucosal involvement. The majority of cases of "Chiclero's ulcer" spontaneously re-epithelialize without treatment within 3-9 months. This patient's lesion completely resolved without therapy after 11 months. "Chiclero's ulcer" should be considered in the differential diagnosis of a patient presenting with a chronic ulcerative lesion and history of travel to an endemic area. Published by Elsevier Ltd. C1 [Blaylock, Jason M.] Walter Reed Army Inst Res, Viral Dis Branch, Silver Spring, MD 20910 USA. [Wortmann, Glenn W.] Walter Reed Natl Mil Med Ctr, Infect Dis Serv, Bethesda, MD 20889 USA. RP Blaylock, JM (reprint author), Walter Reed Army Inst Res, Viral Dis Branch, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM jason.blaylock@med.navy.mil; glenn.w.wortmann@medstar.net NR 22 TC 3 Z9 3 U1 0 U2 2 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1477-8939 J9 TRAVEL MED INFECT DI JI Travel Med. Infect. Dis. PD SEP-NOV PY 2012 VL 10 IS 5-6 BP 275 EP 278 DI 10.1016/j.tmaid.2012.08.005 PG 4 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA 059AC UT WOS:000312675800014 PM 23146325 ER PT J AU Hajifathalian, K Wambeke, BW Liu, M Hsiang, SM AF Hajifathalian, Kiarash Wambeke, Brad W. Liu, Min Hsiang, Simon M. TI Effects of Production Control Strategy and Duration Variance on Productivity and Work in Process: Simulation-Based Investigation SO JOURNAL OF CONSTRUCTION ENGINEERING AND MANAGEMENT-ASCE LA English DT Article DE Productivity; Work in process; Duration variance; Simulation ID CONSTRUCTION AB Improving productivity and reducing work-in-process are two activities that can improve project performance, but are often difficult to accomplish. The construction process is complex and consists of a large number of interdependent and sequential tasks. Construction activities are simulated as serial production lines, using state-and resource-based simulation of construction processes simulation models, to investigate the effects that different production control strategies (push/pull and balanced/unbalanced) have on productivity and work-in-process. The sensitivity to task duration variance is also examined for different working strategies. Simulation results are used to compare the models based on their performance. In the presence of duration variance, push strategies result in higher productivity, whereas pull strategies result in lower amounts of work-in-process. Pull strategies are more sensitive to the presence of duration variance. Work-in-process is also a function of the coefficient of variance. Simulation results are used to compare the tradeoffs between strategies. The findings will help construction managers better understand the effects of working strategies and conditions to decide which production control strategy is best suited for their needs. DOI: 10.1061/(ASCE)CO.1943-7862.0000517. (C) 2012 American Society of Civil Engineers. C1 [Hajifathalian, Kiarash; Liu, Min] N Carolina State Univ, Dept Civil Construct & Environm Engn, Raleigh, NC 27695 USA. [Wambeke, Brad W.] US Mil Acad, Dept Civil & Mech Engn, West Point, NY 10996 USA. [Hsiang, Simon M.] Texas Tech Univ, Lubbock, TX 79409 USA. [Wambeke, Brad W.] USA, West Point, NY 10996 USA. RP Liu, M (reprint author), N Carolina State Univ, Dept Civil Construct & Environm Engn, Raleigh, NC 27695 USA. EM khajifa@ncsu.edu; bwwambek@ncsu.edu; min_liu@ncsu.edu; simon.hsiang@ttu.edu NR 24 TC 2 Z9 2 U1 0 U2 8 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 0733-9364 J9 J CONSTR ENG M ASCE JI J. Constr. Eng. Manage.-ASCE PD SEP PY 2012 VL 138 IS 9 BP 1035 EP 1043 DI 10.1061/(ASCE)CO.1943-7862.0000517 PG 9 WC Construction & Building Technology; Engineering, Industrial; Engineering, Civil SC Construction & Building Technology; Engineering GA 058YT UT WOS:000312671900004 ER PT J AU Cole, DM Ringelberg, DB Reynolds, CM AF Cole, D. M. Ringelberg, D. B. Reynolds, C. M. TI Small-Scale Mechanical Properties of Biopolymers SO JOURNAL OF GEOTECHNICAL AND GEOENVIRONMENTAL ENGINEERING LA English DT Article DE Biopolymer; Soil strengthening; Micromechanics; Laboratory experiments ID SOIL; SUCCINOGLYCAN; BIOFILM; MEDIA AB The use of biopolymers to improve the engineering properties of soil has received attention in recent years, stimulated by potential cost savings and the low environmental impact of this class of materials. The purpose of this work is to improve the understanding of precisely how biopolymers strengthen soil and to quantify the small-scale mechanical properties of biopolymers for implementation in physics-based numerical models. The authors describe the initial efforts to develop viable methods to form biopolymer bonds between grains of naturally occurring materials and present the results of mechanical properties experiments on these bonds. The subject biopolymer was an exopolysaccharide from Rhizobium tropici (ATCC #49672). The initial experiments indicate that the stiffness of bonds ranged from 1 GPa after approximately 1 h of curing to plateau values as high as 3.8 GPa for extended cure times. For bonds with neck areas in the range of 0.01-0.06 mm(2), the cohesive tensile strength of the bonds ranged from 16 to 62 MPa, but averaged approximate to 20 MPa. The associated cohesive failure strains in tension ranged from 0.013 to 0.042. Cyclic loading experiments were conducted to provide information on the mechanical behavior of the biopolymer and to support subsequent constitutive modeling. The results are analyzed and discussed in terms of the underlying viscoelastic behavior, paying particular attention to the variations in stiffness and internal friction as functions of cure time, frequency, and amplitude. DOI: 10.1061/(ASCE)GT.1943-5606.0000680. (C) 2012 American Society of Civil Engineers. C1 [Cole, D. M.; Ringelberg, D. B.; Reynolds, C. M.] USA, Cold Reg Res & Engn Lab, Engn Res & Dev Ctr, Hanover, NH 03755 USA. RP Cole, DM (reprint author), USA, Cold Reg Res & Engn Lab, Engn Res & Dev Ctr, 72 Lyme Rd, Hanover, NH 03755 USA. EM David.M.Cole@usace.army.mil FU ERDC Military Engineering program's basic research project entitled, "Biopolymer Coating Effects on Particle Micro-Structure" FX The authors gratefully acknowledge the support of ERDC Military Engineering program's basic research project entitled, "Biopolymer Coating Effects on Particle Micro-Structure." NR 24 TC 9 Z9 10 U1 1 U2 17 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 1090-0241 J9 J GEOTECH GEOENVIRON JI J. Geotech. Geoenviron. Eng. PD SEP PY 2012 VL 138 IS 9 BP 1063 EP 1074 DI 10.1061/(ASCE)GT.1943-5606.0000680 PG 12 WC Engineering, Geological; Geosciences, Multidisciplinary SC Engineering; Geology GA 059KM UT WOS:000312704000002 ER PT J AU Savant, G Berger, RC AF Savant, Gaurav Berger, R. C. TI Adaptive Time Stepping-Operator Splitting Strategy to Couple Implicit Numerical Hydrodynamic and Water Quality Codes SO JOURNAL OF ENVIRONMENTAL ENGINEERING-ASCE LA English DT Article DE Implicit; Adaptive hydraulics; Runge-Kutta; ADH ID ORDINARY DIFFERENTIAL-EQUATIONS; RUNGE-KUTTA METHOD; MODEL AB Hydrodynamic and water quality codes have been frequently linked. These have typically been linked with both the hydrodynamic and water quality models using similar explicit time steps, but for long-term simulations implicit models are required. The water quality codes linked to these hydrodynamic codes are forced to perform their computations using the hydrodynamic time step even though utilizing the same might result in drifting of the water quality solution. This technical note presents the development and testing of an operator splitting-derived method for linking hydrodynamic and water quality codes with adaptive time stepping. The resulting method provides high-fidelity solutions that compare well with analytic solutions and lends itself for extension to various other transported quantities. DOI: 10.1061/(ASCE)EE.1943-7870.0000547. (C) 2012 American Society of Civil Engineers. C1 [Savant, Gaurav] USA, Corps Engineers, Res & Dev Ctr, Vicksburg, MS 39180 USA. [Berger, R. C.] USA, Corps Engineers, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. EM Gaurav.Savant@usace.army.mil FU U.S. Army Engineer Research and Development Center, Coastal and Hydraulics Laboratory FX The experiments described and the results presented were obtained from research sponsored by the System Wide Water Resources Program (SWWRP) of the U.S. Army Engineer Research and Development Center, Coastal and Hydraulics Laboratory. Permission was granted by the Chief of Engineers to publish this information. NR 17 TC 1 Z9 1 U1 0 U2 2 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 0733-9372 J9 J ENVIRON ENG-ASCE JI J. Environ. Eng.-ASCE PD SEP PY 2012 VL 138 IS 9 BP 979 EP 984 DI 10.1061/(ASCE)EE.1943-7870.0000547 PG 6 WC Engineering, Environmental; Engineering, Civil; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA 051CL UT WOS:000312102000009 ER PT J AU Parker, L Britt, S AF Parker, Louise Britt, Sanford TI The Effect of Bottle Fill Rate and Pour Technique on the Recovery of Volatile Organics SO GROUND WATER MONITORING AND REMEDIATION LA English DT Article ID GROUND-WATER; CONTAMINANTS; ARTIFACTS; QUALITY; SOLUTES; METALS AB This field study was conducted to examine whether the method or the flow rate (fill rate) used to fill a sample vial affects recovery of volatile organics (VOCs). To our knowledge, there have not been any systematic studies that have examined this issue. For this field study, three fill rates (50 mL/min, 250 mL/min, and similar to 1 L/min) and three filling methods (top-pour, side-pour, and bottom-fill) were used to fill sample vials. We found that the bottom-fill method, with the tubing submerged in the sample as it fills, yielded the greatest recovery (i.e., highest concentrations) of VOCs. Little improvement was observed by pouring down the side of a vial vs. simply pouring straight down from the top. We also found that filling the vials at the fastest fill rate (similar to 1 L/min) yielded higher recovery than the slowest fill rate (50 mL/min) using all three filling methods. These results are counter to prevailing guidance and conventional wisdom that slower filling is preferable to faster filling and that pouring down the side of a sample vial is the best practice for VOC sampling. However, because we were unable to randomize the order the samples were collected with respect to fill rate, we recommend a follow-on study be conducted that will allow us to confirm our findings and better determine which fill rates minimize losses of VOCs C1 [Parker, Louise] USA, Corps Engineers, ERDC, CRREL, Hanover, NH 03755 USA. [Britt, Sanford] ProHydro Inc, Fairport, NY 14450 USA. RP Parker, L (reprint author), USA, Corps Engineers, ERDC, CRREL, Hanover, NH 03755 USA. EM louise.v.parker@usace.army.mil; Sandy.Britt@ProHydroInc.com FU Strategic Environmental Research and Development Program (SERDP) FX Thanks to the Strategic Environmental Research and Development Program (SERDP) for funding this project and to Dr. Jeffrey Marqusee Executive Director, Dr. Anne Andrews Deputy Director, and Dr. Andrea Leeson, Environmental Restoration Program Director. Special thanks to Tommie Hall (ERDC-CRREL, Hanover, NH) and the American Environmental Testing Laboratory, Inc. (Burbank, CA) for their excellent assistance in the field work and chemical analyses, respectively. We would also like to thank our reviewers for their useful comments. NR 39 TC 2 Z9 2 U1 0 U2 8 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1069-3629 J9 GROUND WATER MONIT R JI Ground Water Monit. Remediat. PD FAL PY 2012 VL 32 IS 4 BP 78 EP 86 DI 10.1111/j.1745-6592.2012.01401.x PG 9 WC Water Resources SC Water Resources GA 041EZ UT WOS:000311381600021 ER PT J AU Bowen, IR Devlin, JF Schillig, PC AF Bowen, Ian R. Devlin, J. F. Schillig, Peter C. TI Design and Testing of a Convenient Benchtop Sandbox for Controlled Flow Experiments SO GROUND WATER MONITORING AND REMEDIATION LA English DT Article ID HETEROGENEOUS POROUS-MEDIA; GROUNDWATER VELOCITY; TRACER TESTS; TRANSPORT; SCALE; PROBE AB A benchtop sandbox constructed from nested storage tanks (NeSTs), was assembled for studying flow and transport in porous media. Molded plastic storage containers, purchased at a department store, were modified to fashion the tanks. The remaining construction materials were also inexpensive and the NeST design made it virtually leak-proof. The uniformity of flow in the NeST was evaluated with three independent tracer tests. Estimated velocities were within about +/- 20% including all test results, indicating a high degree of predictability and uniformity in the flow. The NeST is a simple and robust tool suitable for research and teaching purposes, particularly for the testing of flow measurement sensors like the point velocity probes. C1 [Devlin, J. F.; Schillig, Peter C.] Univ Kansas, Dept Geol, Lawrence, KS 66045 USA. [Bowen, Ian R.] USA, Corps Engineers, Kansas City, MO USA. RP Devlin, JF (reprint author), Univ Kansas, Dept Geol, Lindley Hall,Rm 120,1475 Jayhawk Blvd, Lawrence, KS 66045 USA. EM jfrickdevlin@gmail.com NR 18 TC 4 Z9 4 U1 1 U2 11 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1069-3629 J9 GROUND WATER MONIT R JI Ground Water Monit. Remediat. PD FAL PY 2012 VL 32 IS 4 BP 87 EP 91 DI 10.1111/j.1745-6592.2012.01400.x PG 5 WC Water Resources SC Water Resources GA 041EZ UT WOS:000311381600022 ER PT J AU Leifer, I Lehr, WJ Simecek-Beatty, D Bradley, E Clark, R Dennison, P Hu, YX Matheson, S Jones, CE Holt, B Reif, M Roberts, DA Svejkovsky, J Swayze, G Wozencraft, J AF Leifer, Ira Lehr, William J. Simecek-Beatty, Debra Bradley, Eliza Clark, Roger Dennison, Philip Hu, Yongxiang Matheson, Scott Jones, Cathleen E. Holt, Benjamin Reif, Molly Roberts, Dar A. Svejkovsky, Jan Swayze, Gregg Wozencraft, Jennifer TI State of the art satellite and airborne marine oil spill remote sensing: Application to the BP Deepwater Horizon oil spill SO REMOTE SENSING OF ENVIRONMENT LA English DT Review DE Oil spill; Deepwater Horizon; Remote sensing; Lidar; Near infrared; Thermal infrared; Satellite; Airborne remote sensing; Synthetic aperture radar; MODIS; Hyperspectral; Multispectral; Expert system; False positives; Technology readiness; Operational readiness; Visible spectrum; Oil water emulsions; Spill response; AVIRIS; Synthetic aperture radar; UAVSAR; Fire; CALIPSO; Oil slick thickness; Laser fluorescence ID APERTURE RADAR IMAGERY; SURFACE-FILMS; SEA-SURFACE; HYDROCARBON SEEPS; PERSIAN-GULF; SAR IMAGES; SLICKS; ALGORITHM; CALIFORNIA; KUWAIT AB The vast and persistent Deepwater Horizon (DWH) spill challenged response capabilities, which required accurate, quantitative oil assessment at synoptic and operational scales. Although experienced observers are a spill response's mainstay, few trained observers and confounding factors including weather, oil emulsification, and scene illumination geometry present challenges. DWH spill and impact monitoring was aided by extensive airborne and spaceborne passive and active remote sensing. Oil slick thickness and oil-to-water emulsion ratios are key spill response parameters for containment/cleanup and were derived quantitatively for thick (>0.1 mm) slicks from AVIRIS (Airborne Visible/Infrared Imaging Spectrometer) data using a spectral library approach based on the shape and depth of near infrared spectral absorption features. MODIS (Moderate Resolution Imaging Spectroradiometer) satellite, visible-spectrum broadband data of surface-slick modulation of sunglint reflection allowed extrapolation to the total slick. A multispectral expert system used a neural network approach to provide Rapid Response thickness class maps. Airborne and satellite synthetic aperture radar (SAR) provides synoptic data under all-sky conditions; however. SAR generally cannot discriminate thick (> 100 mu m) oil slicks from thin sheens (to 0.1 mu m). The UAVSAR's (Uninhabited Aerial Vehicle SAR) significantly greater signal-to-noise ratio and finer spatial resolution allowed successful pattern discrimination related to a combination of oil slick thickness, fractional Surface coverage, and emulsification. In situ burning and smoke plumes were studied with AVIRIS and corroborated spaceborne CALIPSO (Cloud Aerosol Lidar and Infrared Pathfinder Satellite Observation) observations of combustion aerosols. CALIPSO and bathymetry lidar data documented shallow subsurface oil, although ancillary data were required for confirmation. Airborne hyperspectral, thermal infrared data have nighttime and overcast collection advantages and were collected as well as MODIS thermal data. However, interpretation challenges and a lack of Rapid Response Products prevented significant use. Rapid Response Products were key to response utilization data needs are time critical; thus, a high technological readiness level is critical to operational use of remote sensing products. DWH's experience demonstrated that development and operationalization of new spill response remote sensing tools must precede the next major oil spill. (c) 2012 Elsevier Inc. All rights reserved. C1 [Leifer, Ira] Univ Calif Santa Barbara, Inst Marine Sci, Santa Barbara, CA 93106 USA. [Lehr, William J.; Simecek-Beatty, Debra] NOAA, Off Response & Restorat, Seattle, WA USA. [Bradley, Eliza; Roberts, Dar A.] Univ Calif Santa Barbara, Dept Geog, Santa Barbara, CA 93106 USA. [Clark, Roger; Swayze, Gregg] US Geol Survey, Denver, CO 80225 USA. [Dennison, Philip; Matheson, Scott] Univ Utah, Dept Geog, Salt Lake City, UT USA. [Dennison, Philip; Matheson, Scott] Univ Utah, Ctr Nat & Technol Hazards, Salt Lake City, UT USA. [Hu, Yongxiang] NASA, Langley Res Ctr, Hampton, VA 23665 USA. [Jones, Cathleen E.; Holt, Benjamin] CALTECH, Jet Prop Lab, Pasadena, CA USA. [Reif, Molly; Wozencraft, Jennifer] USA, Corp Engineers, Kiln, MS USA. [Svejkovsky, Jan] Ocean Imaging Corp, Solana Beach, CA USA. RP Leifer, I (reprint author), Univ Calif Santa Barbara, Inst Marine Sci, Santa Barbara, CA 93106 USA. EM Ira.Leifer@bubbleology.com RI chen, zhu/K-5923-2013; Hu, Yongxiang/K-4426-2012; OI Leifer, Ira/0000-0002-4674-5775; Dennison, Philip/0000-0002-0241-1917 FU NASA; NOAA; NSF; USGS; Jet Propulsion Laboratory, California Institute of Technology, under a contract with the National Aeronautics and Space Administration; Bureau of Ocean Energy Management, Regulation, and Enforcement (BOEMRE) [M07PC13205] FX We thank the important role and support of NASA, NOAA, NSF, and USGS in the development of these technologies. Some of the research described herein was carried out in part at the Jet Propulsion Laboratory, California Institute of Technology, under a contract with the National Aeronautics and Space Administration. Development of the multispectral rapid response thickness sensor by Ocean Imaging was supported by the Bureau of Ocean Energy Management, Regulation, and Enforcement (BOEMRE) under contract M07PC13205. NSF support enabled the SEBASS data collection. The efforts of Susan Ustin (UC Davis) and Raymond Kokaly (USGS) for ecosystem data collection and analysis and David Tratt for editing are thanked. NR 129 TC 102 Z9 111 U1 14 U2 218 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0034-4257 EI 1879-0704 J9 REMOTE SENS ENVIRON JI Remote Sens. Environ. PD SEP PY 2012 VL 124 BP 185 EP 209 DI 10.1016/j.rse.2012.03.024 PG 25 WC Environmental Sciences; Remote Sensing; Imaging Science & Photographic Technology SC Environmental Sciences & Ecology; Remote Sensing; Imaging Science & Photographic Technology GA 039LQ UT WOS:000311247700016 ER PT J AU Solomon, DJ Tokish, JM AF Solomon, Daniel J. Tokish, John M. TI Superior Labrum, Anterior, and Posterior Tears SO OPERATIVE TECHNIQUES IN SPORTS MEDICINE LA English DT Article DE SLAP; labrum; bicep tendon; glenohumeral ID II SLAP LESIONS; BICEPS LOAD TEST; ARTHROSCOPIC REPAIR; GLENOID LABRUM; CLINICAL-TEST; COMPRESSION TEST; SHOULDER; DIAGNOSIS; OUTCOMES; PATHOLOGY AB Superior labrum, anterior and posterior (SLAP) tears are among the most common injuries seen in the adult shoulder. Several normal anatomic variations occur. This necessitates appropriate understanding of normal anatomy and pathology, including the classifications schemes for SLAP. Tips and techniques for repair of SLAP tears are also discussed. Oper Tech Sports Med 20:238-243 (c) 2012 Elsevier Inc. All rights reserved. C1 [Solomon, Daniel J.] Marin Orthoped & Sport Med, Novato, CA USA. [Tokish, John M.] Tripler Army Med Ctr, Honolulu, HI 96859 USA. RP Solomon, DJ (reprint author), Marin Orthoped & Sport Med, Novato, CA USA. EM dansolly@aol.com NR 44 TC 1 Z9 1 U1 0 U2 8 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 1060-1872 J9 OPER TECHN SPORT MED JI Oper. Tech. Sports Med. PD SEP PY 2012 VL 20 IS 3 BP 238 EP 243 DI 10.1053/j.otsm.2012.09.003 PG 6 WC Sport Sciences; Surgery SC Sport Sciences; Surgery GA 035IG UT WOS:000310939400007 ER PT J AU Alexander, VV Kulkarni, OP Kumar, M Xia, CA Islam, MN Terry, FL Welsh, MJ Ke, K Freeman, MJ Neelakandan, M Chan, A AF Alexander, Vinay V. Kulkarni, Ojas P. Kumar, Malay Xia, Chenan Islam, Mohammed N. Terry, Fred L., Jr. Welsh, Michael J. Ke, Kevin Freeman, Michael J. Neelakandan, Manickam Chan, Allan TI Modulation instability initiated high power all-fiber supercontinuum lasers and their applications SO OPTICAL FIBER TECHNOLOGY LA English DT Article DE Supercontinuum; Mid-infrared; Fiber; ZBLAN; Modulation instability ID PHOTONIC CRYSTAL FIBERS; OPTICAL COHERENCE TOMOGRAPHY; FREE-ELECTRON-LASER; MIDINFRARED ABSORPTION-SPECTROSCOPY; ZBLAN FLUORIDE FIBERS; TIME-AVERAGED POWER; TM-DOPED FIBER; 4.5 MU-M; FEMTOSECOND LASER; CONTINUUM GENERATION AB High average power, all-fiber integrated, broadband supercontinuum (SC) sources are demonstrated. Architecture for SC generation using amplified picosecond/nanosecond laser diode (LD) pulses followed by modulation instability (MI) induced pulse breakup is presented and used to demonstrate SC sources from the mid-IR to the visible wavelengths. In addition to the simplicity in implementation, this architecture allows scaling up of the SC average power by increasing the pulse repetition rate and the corresponding pump power, while keeping the peak power, and, hence, the spectral extent approximately constant. Using this process, we demonstrate > 10 W in a mid-IR SC extending from similar to 0.8 to 4 mu m, > 5 W in a near IR SC extending from similar to 0.8 to 2.8 mu m, and >0.7 W in a visible SC extending from similar to 0.45 to 1.2 mu m. SC modulation capability is also demonstrated in a mid-IR SC laser with similar to 3.9 W in an SC extending from similar to 0.8 to 4.3 mu m. The entire system and SC output in this case is modulated by a 500 Hz square wave at 50% duty cycle without any external chopping or modulation. We also explore the use of thulium doped fiber amplifier (TDFA) stages for mid-IR SC generation. In addition to the higher pump to signal conversion efficiency demonstrated in TDFAs compared to erbium/ytterbium doped fiber amplifier (EYFA), the shifting of the SC pump from similar to 1.5 to similar to 2 mu m is pursued with an attempt to generate a longer extending SC into the mid-IR. We demonstrate similar to 2.5 times higher optical conversion efficiency from pump to SC generation in wavelengths beyond 3.8 mu m in the TDFA versus the EYFA based SC systems. The TDFA SC spectrum extends from similar to 1.9 to 4.5 mu m with similar to 2.6 W at 50% modulation with a 250 Hz square wave. A variety of applications in defense, health care and metrology are also demonstrated using the SC laser systems presented in this paper. (C) 2012 Elsevier Inc. All rights reserved. C1 [Alexander, Vinay V.; Kulkarni, Ojas P.; Kumar, Malay; Xia, Chenan; Islam, Mohammed N.; Terry, Fred L., Jr.; Welsh, Michael J.] Univ Michigan, Dept Elect & Comp Engn, Ann Arbor, MI 48109 USA. [Islam, Mohammed N.] Univ Michigan, Sch Med, Dept Internal Med, Ann Arbor, MI 48109 USA. [Welsh, Michael J.] Univ Michigan, Dept Cell & Dev Biol, Ann Arbor, MI 48109 USA. [Islam, Mohammed N.; Freeman, Michael J.] Omni Sci Inc, Dexter, MI 48105 USA. [Neelakandan, Manickam; Chan, Allan] USA, CERDEC I2WD, Aberdeen Proving Ground, MD 21005 USA. RP Alexander, VV (reprint author), 1301 Beal Ave, Ann Arbor, MI 48109 USA. EM vinalex@umich.edu OI Terry, Fred/0000-0002-0634-5005 FU US Army; US Air Force; Omni Sciences Inc.; Coherix Inc.; University of Michigan FX The works presented here were funded by the US Army, the US Air Force, Omni Sciences Inc., Coherix Inc. and the University of Michigan. The authors would like to thank David J. Carter, James R and Michael Folts. Tice of the Physics Instrument shop at the University of Michigan, for their help in machining parts of the setup used in our experiments. The authors also thank Judy Poore and Jeff Harrison and the Histology Core of the Microscopy and Image Analysis Laboratory core facility at the University of Michigan Medical School for their help in preparing cryostat sections of the biological tissues presented in this study. NR 97 TC 31 Z9 32 U1 3 U2 40 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1068-5200 EI 1095-9912 J9 OPT FIBER TECHNOL JI Opt. Fiber Technol. PD SEP PY 2012 VL 18 IS 5 BP 349 EP 374 DI 10.1016/j.yofte.2012.07.014 PG 26 WC Engineering, Electrical & Electronic; Optics; Telecommunications SC Engineering; Optics; Telecommunications GA 031NK UT WOS:000310648500012 ER PT J AU Gurram, P Kwon, H Han, T AF Gurram, Prudhvi Kwon, Heesung Han, Timothy TI Sparse Kernel-Based Hyperspectral Anomaly Detection SO IEEE GEOSCIENCE AND REMOTE SENSING LETTERS LA English DT Article DE Hyperspectral anomaly detection; sparse kernel-based ensemble learning (SKEL); support vector data description (SVDD) ID IMAGERY AB In this letter, a novel ensemble-learning approach for anomaly detection is presented. The proposed technique aims to optimize an ensemble of kernel-based one-class classifiers, such as support vector data description (SVDD) classifiers, by estimating optimal sparse weights of the subclassifiers. In this method, the features of a given multivariate data set representing normalcy are first randomly subsampled into a large number of feature subspaces. An enclosing hypersphere that defines the support of the normalcy data in the reproducing kernel Hilbert space (RKHS) of each respective feature subspace is estimated using standard SVDD. The joint hypersphere in the RKHS of the combined kernel is learned by optimally combining the weighted individual kernels while imposing the l1 constraint on the combining weights. The joint hypersphere representing the optimal compact support of the multivariate data in the joint RKHS is then used to test a new data point to determine if it belongs to the normalcy data or not. A performance comparison between the proposed algorithm and regular SVDD is reported using hyperspectral image data as well as general multivariate data. C1 [Gurram, Prudhvi; Kwon, Heesung] USA, Res Lab, Adelphi, MD 20783 USA. [Han, Timothy] Agilex Technol Inc, Chantilly, VA 20151 USA. RP Gurram, P (reprint author), USA, Res Lab, Adelphi, MD 20783 USA. EM pkgurram@gmail.com; heesung.kwon@us.army.mil; Timothy.Han@agilex.com RI Yin, Wotao/A-5472-2011 OI Yin, Wotao/0000-0001-6697-9731 NR 11 TC 14 Z9 17 U1 0 U2 25 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1545-598X J9 IEEE GEOSCI REMOTE S JI IEEE Geosci. Remote Sens. Lett. PD SEP PY 2012 VL 9 IS 5 BP 943 EP 947 DI 10.1109/LGRS.2012.2187040 PG 5 WC Geochemistry & Geophysics; Engineering, Electrical & Electronic; Remote Sensing; Imaging Science & Photographic Technology SC Geochemistry & Geophysics; Engineering; Remote Sensing; Imaging Science & Photographic Technology GA 035BA UT WOS:000310915500030 ER PT J AU Raines, EF AF Raines, Edgar F., Jr. TI US Army Doctrine: From the American Revolution to the War on Terror SO JOURNAL OF AMERICAN HISTORY LA English DT Book Review C1 [Raines, Edgar F., Jr.] USA, Ctr Mil Hist, Washington, DC 20310 USA. RP Raines, EF (reprint author), USA, Ctr Mil Hist, Washington, DC 20310 USA. NR 1 TC 0 Z9 0 U1 0 U2 1 PU ORGANIZATION AMER HISTORIANS PI BLOOMINGTON PA 112 N BRYAN ST, BLOOMINGTON, IN 47408 USA SN 0021-8723 J9 J AM HIST JI J. Am. Hist. PD SEP PY 2012 VL 99 IS 2 BP 563 EP 563 DI 10.1093/jahist/jas210 PG 1 WC History SC History GA 995OD UT WOS:000308018300014 ER PT J AU Capitolo, PJ Carter, HR Jaques, DL McChesney, GJ McIver, WR Keeney, TW Smith, G AF Capitolo, Phillip J. Carter, Harry R. Jaques, Deborah L. McChesney, Gerard J. McIver, William R. Keeney, Thomas W. Smith, Grace TI Roosting Brown Pelicans at San Nicolas Island, California, 1972-2006 SO WATERBIRDS LA English DT Article DE Brown Pelican; disturbance; El Nino; nesting; Pelecanus occidentalis; roosting; San Nicolas Island; Southern California Bight AB To assist long-term protection of roost sites, roosting patterns of California Brown Pelicans (Pelecanus occidentalis californicus) at San Nicolas Island (SNI), California, were assessed for the 1972-2006 period. SNI was used for roosting year-round, with most birds likely from nearest primary, breeding colonies (Santa Barbara and Anacapa islands) within the Southern California Bight subpopulation. Among non-El Nino years, monthly diurnal counts varied, but ranged from less than 100 birds during the breeding season to approximately 1,000 during fall. Influxes from the large Gulf of California subpopulation also occurred on occasion, best demonstrated by prolonged increased numbers during strong El Nino conditions in 1972-1973, possibly reflecting delayed or skipped breeding and increased prey availability near the outer California Channel Islands. The peak estimate of 13,500 night-roosting pelicans was on 16 November 1972 during these El Nino conditions. Most pelicans roosted diurnally on the north shore, reflecting close proximity to main foraging areas. Diurnal roost patterns did not appear affected by introduced feral cats (Felis catus) and Island Foxes (Urocyon littoralis dickeyi). The single, major night roost shifted 4 km from Cormorant Rock Area (used 1972-1992) to Vizcaino Point by 2006, following reduction of human disturbance in 1992-1996. Vizcaino Point and Cormorant Rock Area should be designated as "key, long-semi roosts" that merit additional protection. Received 25 July 2011, accepted 14 March 2012. C1 [Capitolo, Phillip J.] Univ Calif Santa Cruz, Inst Marine Sci, Santa Cruz, CA 95060 USA. [Carter, Harry R.] Carter Biol Consulting, Victoria, BC V8S 4S8, Canada. [Carter, Harry R.; McChesney, Gerard J.; McIver, William R.] Humboldt State Univ, Dept Wildlife, Arcata, CA 95521 USA. [Jaques, Deborah L.] Pacific Eco Log, Astoria, OR 97103 USA. [Keeney, Thomas W.] USA, Corps Engineers, Planning Div, Environm Resources Branch, Los Angeles, CA 90017 USA. [Smith, Grace] USN, NAWCWD Range Sustainabil Off, Point Mugu Nawc, CA 93042 USA. RP Capitolo, PJ (reprint author), Univ Calif Santa Cruz, Inst Marine Sci, 100 Shaffer Rd, Santa Cruz, CA 95060 USA. EM phil.capitolo@gmail.com FU USN; Humboldt State University (HSU) FX Funding for surveys in 2006 was provided to University of California, Santa Cruz (UCSC; Principal Investigator: W B. Tyler) and Pacific EcoLogic by USN, with assistance from Grace Smith (USN). Flight support was provided by the California Department of Fish and Game (CDFG; Air Services), with assistance from J. Yamamoto (CDFG-Office of Spill Prevention and Response [OSPR]). L. Van Der Kamp, R. Chace, J. Moody (UCSC), T. Sheperd and R. Guieb (USN) provided administrative assistance. H. Gellerman (Engineering Management Concepts, Camarillo, California; EMC) and Gina Smith (USN) provided logistical support for ground surveys. H. Gellerman (EMC) assisted surveys.; Aerial surveys in 1992-1993 by Crescent Coastal Research were funded through Humboldt State University (HSU) by USN (Point Mugu Naval Air Station; Principal Investigator: D. Jaques), with assistance from T. Keeney and H. Carter. Ground surveys in 1992-1994 by HSU and USN were funded by USN (Legacy Resources Management Program; Principal Investigators: H. Carter and T. Keeney). J. Feldman, J. Hosokawa, C. Lombardo, T. Miner, L. Ochikubo, C. Strong, A. Whelchel and W Whetje assisted surveys. NR 34 TC 0 Z9 0 U1 1 U2 15 PU WATERBIRD SOC PI WASHINGTON PA NATL MUSEUM NATURAL HISTORY SMITHSONIAN INST, WASHINGTON, DC 20560 USA SN 1524-4695 J9 WATERBIRDS JI Waterbirds PD SEP PY 2012 VL 35 IS 3 BP 443 EP 452 PG 10 WC Ornithology SC Zoology GA 025JK UT WOS:000310184700009 ER PT J AU Lieser, AC Zacherl, CL Saengdeejing, A Liu, ZK Kecskes, LJ AF Lieser, Alyson C. Zacherl, Chelsey L. Saengdeejing, Arkapol Liu, Zi-Kui Kecskes, Laszlo J. TI First-principles calculations and thermodynamic re-modeling of the Hf-W system SO CALPHAD-COMPUTER COUPLING OF PHASE DIAGRAMS AND THERMOCHEMISTRY LA English DT Article DE Hafnium; Tungsten alloys; Thermodynamic modeling; First-principles calculations; Special quasirandom structures; Debye-Gruneisen model ID TUNGSTEN; HAFNIUM; ALLOYS; ENERGY; NI; SCIENCE AB An integrative approach coupling first-principles calculations and the CALculation of PHAse Diagram (CALPHAD) method provides a more thermodynamically accurate model of the Hf-W system when compared to previous models. A two-sublattice model is used for describing the solid solubility of the HfW2 Laves phase. The modeling of the Laves phase includes input from first-principles total energy calculations and predictions of finite temperature properties from the Debye-Gruneisen model. In addition, first-principles calculations performed on hcp and bcc special quasirandom structures (SQS) predicted a positive enthalpy of mixing in both solid solution phases. Predicting the finite temperature properties of bcc SQS with the Debye-Gruneisen model was necessary to balance the positive, asymmetric enthalpy of mixing found in the bcc solid solution. The model produced by the coupling of CALPHAD modeling with first-principles calculations agrees well with experimental data. It also reproduces the Hf-W phase diagram with fewer parameters than previous models, which were created without the aid of first-principles calculations. (C) 2012 Elsevier Ltd. All rights reserved. C1 [Lieser, Alyson C.; Zacherl, Chelsey L.; Saengdeejing, Arkapol; Liu, Zi-Kui] Penn State Univ, Dept Mat Sci & Engn, University Pk, PA 16802 USA. [Kecskes, Laszlo J.] USA, Res Lab, Weap & Mat Res Directorate, RDRL WMM F, Aberdeen Proving Ground, MD 21005 USA. RP Lieser, AC (reprint author), Penn State Univ, Dept Mat Sci & Engn, University Pk, PA 16802 USA. EM zql5071@psu.edu RI Kecskes, Laszlo/F-6880-2014; Hargather, Chelsey/G-6972-2014; Liu, Zi-Kui/A-8196-2009 OI Kecskes, Laszlo/0000-0002-1342-3729; Hargather, Chelsey/0000-0002-1446-9112; Liu, Zi-Kui/0000-0003-3346-3696 FU U.S. Army Research Laboratory [W911NF-08-2-0064]; Materials Simulation Center; Research and Computing Cyberinfrastructure; National Science foundation [OCI-0821527] FX The financial support from U.S. Army Research Laboratory under contract W911NF-08-2-0064 is greatly appreciated. First-principles calculations for this work were carried out on the LION clusters at the Pennsylvania State University supported by the Materials Simulation Center and the Research and Computing Cyberinfrastructure and in part through instrumentation funded by the National Science foundation grant OCI-0821527. The authors would like to thank Dr. Shun-Li Shang for the use of his scripts. NR 37 TC 7 Z9 7 U1 2 U2 16 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0364-5916 EI 1873-2984 J9 CALPHAD JI Calphad-Comput. Coupling Ph. Diagrams Thermochem. PD SEP PY 2012 VL 38 BP 92 EP 99 DI 10.1016/j.calphad.2012.04.005 PG 8 WC Thermodynamics; Chemistry, Physical; Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Thermodynamics; Chemistry; Materials Science; Metallurgy & Metallurgical Engineering GA 013MP UT WOS:000309309800011 ER PT J AU Hedden, AS Dietlein, CR Wikner, DA AF Hedden, Abigail S. Dietlein, Charles R. Wikner, David A. TI Design of 220 GHz electronically scanned reflectarrays for confocal imaging systems SO OPTICAL ENGINEERING LA English DT Article DE millimeter wave technology; millimeter wave imaging; scanning radar architecture; scanning reflectarray; phased arrays ID PHASE SHIFTERS; MILLIMETER-WAVE; BAND; TRANSMISSION; TERAHERTZ AB The authors analyze properties of a 220 GHz imaging system that uses a scanned reflectarray to perform electronic beam scanning of a confocal imager for applications including imaging meter-sized fields of view at 50 m standoff. Designs incorporating reflectarrays with confocal imagers have not been examined previously at these frequencies. We examine tradeoffs between array size, overall system size, and number of achievable image pixels resulting in a realistic architecture capable of meeting the needs of our application. Impacts to imaging performance are assessed through encircled energy calculations, beam pointing accuracy, and examining the number and intensity of quantization lobes that appear over the scan ranges of interest. Over the desired scan range, arrays with 1 and 2-bit phase quantization showed similar array main beam energy efficiencies. Two-bit phase quantization is advantageous in terms of pointing angle error, resulting in errors of at most 15% of the diffraction-limited beam size. However, both phase quantization cases considered resulted in spurious returns over the scan range of interest and other array layouts should be examined to eliminate potential imaging artifacts. (C) 2012 Society of Photo-Optical Instrumentation Engineers (SPIE). [DOI: 10.1117/1.OE.51.9.091611] C1 [Hedden, Abigail S.; Dietlein, Charles R.; Wikner, David A.] USA, Res Lab, Adelphi, MD 20783 USA. RP Hedden, AS (reprint author), USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM abigail.s.hedden.civ@mail.mil NR 22 TC 1 Z9 1 U1 3 U2 12 PU SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98225 USA SN 0091-3286 J9 OPT ENG JI Opt. Eng. PD SEP PY 2012 VL 51 IS 9 AR 091611 DI 10.1117/1.OE.51.9.091611 PG 10 WC Optics SC Optics GA 021VZ UT WOS:000309914800016 ER PT J AU Mait, JN Martin, RD Schuetz, CA Prather, DW AF Mait, Joseph N. Martin, Richard D. Schuetz, Christopher A. Prather, Dennis W. TI Millimeter wave imaging with engineered point spread functions SO OPTICAL ENGINEERING LA English DT Article DE imaging systems; phase-only filters; point spread functions; millimeter waves ID PUPIL-FUNCTION DESIGN; ARRAYS AB We demonstrate experimentally the ability to shape the point spread function of a distributed-aperture millimeter-wave imaging system by modifying its aperture phase. We consider distributions on a regular hexagonal array and a nonredundant array. We also show how to exploit this capability to perform low-resolution analog image processing. A preliminary investigation of system performance reveals nonuniformity in amplitude response across the array is a major contributor to deviations from predicted point spread functions (PSFs). (C) 2012 Society of Photo-Optical Instrumentation Engineers (SPIE). [DOI: 10.1117/1.OE.51.9.091606] C1 [Mait, Joseph N.] USA, Res Lab, Adelphi, MD 20783 USA. [Martin, Richard D.; Schuetz, Christopher A.] Phase Sensit Innovat, Newark, DE 19711 USA. [Prather, Dennis W.] Univ Delaware, Dept Elect & Comp Engn, Newark, DE 19716 USA. RP Mait, JN (reprint author), USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM joseph.n.mait2.civ@mail.mil NR 17 TC 1 Z9 1 U1 1 U2 10 PU SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98225 USA SN 0091-3286 EI 1560-2303 J9 OPT ENG JI Opt. Eng. PD SEP PY 2012 VL 51 IS 9 AR 091606 DI 10.1117/1.OE.51.9.091606 PG 9 WC Optics SC Optics GA 021VZ UT WOS:000309914800011 ER PT J AU Patel, VM Mait, JN AF Patel, Vishal M. Mait, Joseph N. TI Compressive passive millimeter wave imaging with extended depth of field SO OPTICAL ENGINEERING LA English DT Article DE computational imaging; millimeter wave imaging; extended depth-of-field; image reconstruction; sparsity ID RECONSTRUCTION; SYSTEMS AB We introduce a millimeter wave imaging modality with extended depth-of-field that provides diffraction-limited images with reduced-spatial sampling. The technique uses a cubic phase element in the pupil of the system and a nonlinear recovery algorithm to produce images that are insensitive to object distance. We present experimental results that validate system performance and demonstrate a greater than four-fold increase in depth-of-field with a reduction in sampling requirements by a factor of at least two. (C) 2012 Society of Photo-Optical Instrumentation Engineers (SPIE). [DOI: 10.1117/1.OE.51.9.091610] C1 [Patel, Vishal M.] Univ Maryland, Ctr Automat Res, UMIACS, College Pk, MD 20742 USA. [Mait, Joseph N.] USA, Res Lab, RDRL SER, Adelphi, MD 20783 USA. RP Patel, VM (reprint author), Univ Maryland, Ctr Automat Res, UMIACS, College Pk, MD 20742 USA. EM pvishalm@gmail.com FU Multidisciplinary University Research Initiative from the Army Research Office [W911NF-09-1-0383] FX The authors would like to thank Charles Dietlein of Army Research Labfor fruitful observations and comments on our work and to Professor Rama Chellappa of the University of Maryland for engaging discussions about the project. This work was partially supported by a Multidisciplinary University Research Initiative from the Army Research Office under the Grant W911NF-09-1-0383. NR 19 TC 4 Z9 4 U1 1 U2 11 PU SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98225 USA SN 0091-3286 J9 OPT ENG JI Opt. Eng. PD SEP PY 2012 VL 51 IS 9 AR 091610 DI 10.1117/1.OE.51.9.091610 PG 7 WC Optics SC Optics GA 021VZ UT WOS:000309914800015 ER PT J AU Krairojananan, P Sattabongkot, J Chavalitshewinkoon-Petmitr, P AF Krairojananan, Panadda Sattabongkot, Jetsumon Chavalitshewinkoon-Petmitr, Porntip TI EFFECT OF PERITROPHIC MATRIX C- TYPE LECTIN (AdPMCTL) ON BLOOD-MEAL SIZE IN ANOPHELES DIRUS SO SOUTHEAST ASIAN JOURNAL OF TROPICAL MEDICINE AND PUBLIC HEALTH LA English DT Article DE Anopheles dirus; Anopheles gambiae; C-type lectin; gene silencing; peritrophic matrix ID PARASITE CHITINASE; GAMBIAE; MOSQUITOS; MEMBRANE; IDENTIFICATION; EXPRESSION; STEPHENSI; INVASION; PROTEIN; GENE AB The peritrophic matrix (PM) is penetrated by Plasmodium ookinete to permit transition to oocyst in the mosquito midgut, the manner by which the ookinete interacts with glycoproteins on the PM remains poorly understood. We partially characterized peritrophic matrix C-type lectin (PMCTL) from An. gambiae (CTL10) and An. dirus (AdPMCTL). AdPMCTL protein was produced specifically in blood-fed mosquitoes. The 320 amino acid AdPMCTL exhibits 72% identity with a putative secreted An. gambiae ortholog (AGAP009316, CTL10). AdPMCTL was cloned and its expression profile determined in sugar- and blood-fed midguts. RNAi was used to determine the effect of AdPMCTL on blood meal size and on mosquito survival. AdPMCTL mRNA was present in midguts of sugar-fed mosquitoes and exhibited up-regulation following a blood meal, and AdPMCTL silencing significantly influenced the blood-meal size of engorged mosquitoes, suggesting a role for AdPMCTL as a stabilizing linker molecule, which limits PM distension after blood feeding. C1 [Krairojananan, Panadda; Chavalitshewinkoon-Petmitr, Porntip] Mahidol Univ, Fac Trop Med, Dept Protozool, Bangkok 10400, Thailand. [Krairojananan, Panadda] Armed Forces Res Inst Med Sci, Dept Entomol, Bangkok 10400, Thailand. [Sattabongkot, Jetsumon] Mahidol Univ, Fac Trop Med, Mahidol Vivax Res Ctr, Bangkok 10400, Thailand. RP Krairojananan, P (reprint author), Mahidol Univ, Fac Trop Med, Dept Protozool, 420-6 Rajvithi Rd, Bangkok 10400, Thailand. EM pkrairojananan@yahoo.com FU Johns Hopkins Malaria Research Institute FX This work was partially supported by a grant from the Johns Hopkins Malaria Research Institute short-term fellowship program for endemic-area scientists. We are grateful to Ms Somporn Krasaesub for statistical analysis, and to members of the Insectary Section and Lab Sciences Section, Department of Entomology, AFRIMS, for providing An. dirus mosquitoes and assistance in artificial membrane feeding. NR 25 TC 1 Z9 1 U1 0 U2 3 PU SOUTHEAST ASIAN MINISTERS EDUC ORGANIZATION PI BANGKOK PA SEAMEO-TROPMED, 420-6 RAJVITHI RD,, BANGKOK 10400, THAILAND SN 0125-1562 J9 SE ASIAN J TROP MED JI Southeast Asian J. Trop. Med. Public Health PD SEP PY 2012 VL 43 IS 5 BP 1134 EP 1145 PG 12 WC Public, Environmental & Occupational Health; Infectious Diseases; Tropical Medicine SC Public, Environmental & Occupational Health; Infectious Diseases; Tropical Medicine GA 018DE UT WOS:000309639500008 PM 23431819 ER PT J AU Seifert, K Gandia, NC Wilburn, JK Bower, KS Sia, RK Ryan, DS Deaton, ML Still, KM Vassilev, VC Laurie, GW McKown, RL AF Seifert, Kyle Gandia, Natasha C. Wilburn, Jennifer K. Bower, Kraig S. Sia, Rose K. Ryan, Denise S. Deaton, Michael L. Still, Katherine M. Vassilev, Veronica C. Laurie, Gordon W. McKown, Robert L. TI Tear Lacritin Levels by Age, Sex, and Time of Day in Healthy Adults SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Article ID LINKED-IMMUNOSORBENT-ASSAY; NORMAL YOUNG-ADULTS; DRY EYE; PROTEIN-LEVELS; 2-DIMENSIONAL ELECTROPHORESIS; ARRAY CHARACTERIZATION; MASS-SPECTROMETRY; LACRIMAL GLAND; FLUID; VARIABILITY AB PURPOSE. Several small proteomic studies suggest that the prosecretory tear protein lacritin may be selectively downregulated in dry eye syndrome and in blepharitis, yet little information is available about normal baseline levels. This study assessed lacritin levels in tears from healthy individuals and addressed whether they differ according to sex, age, or time of day. METHODS. Rabbit antibodies against lacritin N-terminal peptide EDASSDSTGADPAQEAGTS (Pep Lac N-Term) were generated and characterized against human recombinant lacritin and N-65 truncation mutant. Basal tears were collected from 66 healthy individuals ranging in age from 18 to 52 years, and at four times during one 24-hour period from 34 other individuals. Lacritin levels were then analyzed by ELISA and Western blotting. RESULTS. Anti-Pep Lac N-Term bound lacritin, but not truncation mutant N-65 that lacks the N-terminal antigenic site. Tear lacritin levels followed a normal distribution with a mean of 4.2 +/- 1.17 ng/100 ng total tear protein. Levels differed little by age or sex, and decreased slightly between 4 and 8 hours in a 24-hour cycle. Tear-blocking effects were minimal, as suggested by spiking of tears with recombinant lacritin. CONCLUSIONS. Anti-Pep Lac N-Term-detectable lacritin comprises similar to 4.2 ng/100 ng total tear protein in healthy individuals, with no significant differences between males and females or among individuals between 18 and 52 years old. Levels decrease slightly in the late afternoon. These findings provide a baseline for future immunodiagnostic studies of lacritin in dry eye and other ocular diseases. (Invest Ophthalmol Vis Sci. 2012;53:6610-6616) DOI:10.1167/iovs.11-8729 C1 [Deaton, Michael L.; Still, Katherine M.; Vassilev, Veronica C.; McKown, Robert L.] James Madison Univ, Dept Integrated Sci & Technol, Harrisonburg, VA 22807 USA. [Seifert, Kyle; Gandia, Natasha C.; Wilburn, Jennifer K.] James Madison Univ, Dept Biol, Harrisonburg, VA 22807 USA. [Bower, Kraig S.] Johns Hopkins Univ, Wilmer Eye Inst, Baltimore, MD 21218 USA. [Sia, Rose K.; Ryan, Denise S.] Walter Reed Army Med Ctr, Ctr Refract Surg, Washington, DC 20307 USA. [Laurie, Gordon W.] Univ Virginia, Dept Cell Biol, Charlottesville, VA USA. RP McKown, RL (reprint author), James Madison Univ, Dept Integrated Sci & Technol, 701 Carrier Dr, Harrisonburg, VA 22807 USA. EM mckownrl@jmu.edu FU Virginia's Commonwealth Health Research Board; NIH [RO1 EY013143, RO1 EY018222] FX Supported by grant funding from Virginia's Commonwealth Health Research Board (KS and RLM), NIH RO1 EY013143, and NIH RO1 EY018222 (GWL). NR 40 TC 7 Z9 7 U1 0 U2 2 PU ASSOC RESEARCH VISION OPHTHALMOLOGY INC PI ROCKVILLE PA 12300 TWINBROOK PARKWAY, ROCKVILLE, MD 20852-1606 USA SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD SEP PY 2012 VL 53 IS 10 BP 6610 EP 6616 DI 10.1167/iovs.11-8729 PG 7 WC Ophthalmology SC Ophthalmology GA 016NQ UT WOS:000309526200079 PM 22918641 ER PT J AU Fang, X Wallqvist, A Reifman, J AF Fang, Xin Wallqvist, Anders Reifman, Jaques TI Modeling Phenotypic Metabolic Adaptations of Mycobacterium tuberculosis H37Rv under Hypoxia SO PLOS COMPUTATIONAL BIOLOGY LA English DT Article ID GENE-EXPRESSION; SACCHAROMYCES-CEREVISIAE; SYSTEMS BIOLOGY; LATENT TUBERCULOSIS; PROTEIN EXPRESSION; DRUG DISCOVERY; TRANSCRIPTIONAL REGULATION; MACROMOLECULAR-COMPOSITION; STATIONARY-PHASE; ALPHA-CRYSTALLIN AB The ability to adapt to different conditions is key for Mycobacterium tuberculosis, the causative agent of tuberculosis (TB), to successfully infect human hosts. Adaptations allow the organism to evade the host immune responses during acute infections and persist for an extended period of time during the latent infectious stage. In latently infected individuals, estimated to include one-third of the human population, the organism exists in a variety of metabolic states, which impedes the development of a simple strategy for controlling or eradicating this disease. Direct knowledge of the metabolic states of M. tuberculosis in patients would aid in the management of the disease as well as in forming the basis for developing new drugs and designing more efficacious drug cocktails. Here, we propose an in silico approach to create state-specific models based on readily available gene expression data. The coupling of differential gene expression data with a metabolic network model allowed us to characterize the metabolic adaptations of M. tuberculosis H37Rv to hypoxia. Given the microarray data for the alterations in gene expression, our model predicted reduced oxygen uptake, ATP production changes, and a global change from an oxidative to a reductive tricarboxylic acid (TCA) program. Alterations in the biomass composition indicated an increase in the cell wall metabolites required for cell-wall growth, as well as heightened accumulation of triacylglycerol in preparation for a low-nutrient, low metabolic activity life style. In contrast, the gene expression program in the deletion mutant of dosR, which encodes the immediate hypoxic response regulator, failed to adapt to low-oxygen stress. Our predictions were compatible with recent experimental observations of M. tuberculosis activity under hypoxic and anaerobic conditions. Importantly, alterations in the flow and accumulation of a particular metabolite were not necessarily directly linked to differential gene expression of the enzymes catalyzing the related metabolic reactions. C1 [Fang, Xin; Wallqvist, Anders; Reifman, Jaques] USA, DoD Biotechnol High Performance Comp Software App, Telemed & Adv Technol Res Ctr, Med Res & Mat Command, Ft Detrick, MD USA. RP Fang, X (reprint author), USA, DoD Biotechnol High Performance Comp Software App, Telemed & Adv Technol Res Ctr, Med Res & Mat Command, Ft Detrick, MD USA. EM jaques.reifman@us.army.mil OI wallqvist, anders/0000-0002-9775-7469 FU competitive In-house Laboratory Independent Research (ILIR) award by the U.S. Army Assistant Secretary of the Army for Acquisition, Logistics, and Technology (ASAALT) FX This project was funded in part by a competitive In-house Laboratory Independent Research (ILIR) award by the U.S. Army Assistant Secretary of the Army for Acquisition, Logistics, and Technology (ASAALT). The opinions and assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the U.S. Army or the U.S. Department of Defense. This paper has been approved for public release with unlimited distribution. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 73 TC 26 Z9 28 U1 1 U2 19 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1553-7358 J9 PLOS COMPUT BIOL JI PLoS Comput. Biol. PD SEP PY 2012 VL 8 IS 9 AR e1002688 DI 10.1371/journal.pcbi.1002688 PG 14 WC Biochemical Research Methods; Mathematical & Computational Biology SC Biochemistry & Molecular Biology; Mathematical & Computational Biology GA 016IJ UT WOS:000309510900025 PM 23028286 ER PT J AU Chomel, BB McMillan-Cole, AC Kasten, RW Stuckey, MJ Sato, S Maruyama, S Diniz, PPVP Breitschwerdt, EB AF Chomel, Bruno B. McMillan-Cole, Audrey C. Kasten, Rickie W. Stuckey, Matthew J. Sato, Shingo Maruyama, Soichi Diniz, Pedro P. V. P. Breitschwerdt, Edward B. TI Candidatus Bartonella merieuxii, a Potential New Zoonotic Bartonella Species in Canids from Iraq SO PLOS NEGLECTED TROPICAL DISEASES LA English DT Article ID INFECTIVE ENDOCARDITIS; SEROLOGICAL EVIDENCE; DOMESTIC CATS; GRAY FOXES; B-HENSELAE; DOGS; CLARRIDGEIAE; CALIFORNIA; SPP.; IDENTIFICATION AB Bartonellae are emerging vector-borne pathogens infecting erythrocytes and endothelial cells of various domestic and wild mammals. Blood samples were collected from domestic and wild canids in Iraq under the United States Army zoonotic disease surveillance program. Serology was performed using an indirect immunofluorescent antibody test for B. henselae, B. clarridgeiae, B. vinsonii subsp. berkhoffii and B. bovis. Overall seroprevalence was 47.4% in dogs (n = 97), 40.4% in jackals (n = 57) and 12.8% in red foxes (n = 39). Bartonella species DNA was amplified from whole blood and representative strains were sequenced. DNA of a new Bartonella species similar to but distinct from B. bovis, was amplified from 37.1% of the dogs and 12.3% of the jackals. B. vinsonii subsp. berkhoffii was also amplified from one jackal and no Bartonella DNA was amplified from foxes. Adjusting for age, the odds of dogs being Bartonella PCR positive were 11.94 times higher than for wild canids (95% CI: 4.55-31.35), suggesting their role as reservoir for this new Bartonella species. This study reports on the prevalence of Bartonella species in domestic and wild canids of Iraq and provides the first detection of Bartonella in jackals. We propose Candidatus Bartonella merieuxii for this new Bartonella species. Most of the Bartonella species identified in sick dogs are also pathogenic for humans. Therefore, seroprevalence in Iraqi dog owners and bacteremia in Iraqi people with unexplained fever or culture negative endocarditis requires further investigation as well as in United States military personnel who were stationed in Iraq. Finally, it will also be essential to test any dog brought back from Iraq to the USA for presence of Bartonella bacteremia to prevent any accidental introduction of a new Bartonella species to the New World. C1 [Chomel, Bruno B.; Kasten, Rickie W.; Stuckey, Matthew J.] Univ Calif Davis, Sch Vet Med, Dept Populat Hlth & Reprod, Davis, CA 95616 USA. [McMillan-Cole, Audrey C.] Tripler Army Med Ctr, Publ Hlth Command Reg Pacific, Honolulu, HI 96859 USA. [Sato, Shingo; Maruyama, Soichi] Nihon Univ, Coll Bioresource Sci, Dept Vet Med, Lab Vet Publ Hlth, Fujisawa, Kanagawa, Japan. [Diniz, Pedro P. V. P.] Western Univ Hlth Sci, Coll Vet Med, Pomona, CA USA. [Breitschwerdt, Edward B.] N Carolina State Univ, Coll Vet Med, Intracellular Pathogens Res Lab, Ctr Comparat Med & Translat Res, Raleigh, NC USA. RP Chomel, BB (reprint author), Univ Calif Davis, Sch Vet Med, Dept Populat Hlth & Reprod, Davis, CA 95616 USA. EM bbchomel@ucdavis.edu RI Diniz, Pedro Paulo/B-2794-2013 FU US Army contract (USAMRAA/WRAIR) [W81XWH10P0215] FX The project was funded under a US Army contract (USAMRAA/WRAIR Contract Number: W81XWH10P0215). The funders had no role in study design, data collection* and analysis, or preparation of the manuscript. Decision to publish was approved by Public Affairs and Dr. McMillan-Cole supervisors (e-mail of Dr. McMillan-Cole of April 19, 2012). * Sample collection was performed by the military under the supervision of United States Army zoonotic disease surveillance program. NR 42 TC 10 Z9 11 U1 2 U2 12 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1935-2735 J9 PLOS NEGLECT TROP D JI Plos Neglect. Trop. Dis. PD SEP PY 2012 VL 6 IS 9 AR e1843 DI 10.1371/journal.pntd.0001843 PG 9 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA 016OH UT WOS:000309528100039 PM 23029597 ER PT J AU Valente, JJ King, SL Wilson, RR AF Valente, Jonathon J. King, Sammy L. Wilson, R. Randy TI Summer use of Rice Fields by Secretive Marsh Birds in the Mississippi Alluvial Valley of Northeast Louisiana SO SOUTHEASTERN NATURALIST LA English DT Article ID SOUTHWESTERN LOUISIANA; AGRICULTURAL WETLANDS; MEDITERRANEAN REGION; SITE OCCUPANCY; HABITAT USE; WATERBIRDS; PATTERNS; SUCCESS; RAILS AB Many secretive marsh bird (SMB) species nest within rice fields, yet in most regions we do not understand the extent to which these birds use such habitats. In the summers of 2007 and 2008, we investigated summer use of rice fields by SMBs in north-east Louisiana and evaluated the local (within 100 m) and landscape (within 1 km) habitat characteristics influencing site selection. We did not encounter any SMB species in 2007, but we encountered low densities of Ixobrychus exilis (Least Bitterns), Rallus elegans (King Rails), and Fulica americana (American Coots) in mid-July of 2008. It is unclear whether or not the birds we detected were actually breeding in the rice fields, or merely using them as late summer foraging areas. When we combined detections of all species, we found that probability of occupancy was positively influenced by the proportion of the local habitat dominated by flooded ditches containing herbaceous emergent vegetation. Ditches likely provide refuge and resource alternatives that may be particularly important to these birds in the late summer when rice fields are drained and harvested. However, given that SMBs were detected at less than 10% of the 72 rice fields we surveyed, it appears as though Mississippi Alluvial Valley rice fields contribute very little toward supporting SMB populations. C1 [Valente, Jonathon J.] Louisiana State Univ, Sch Renewable Nat Resources, Baton Rouge, LA 70803 USA. [King, Sammy L.] Louisiana State Univ, Sch Renewable Nat Resources 124, US Geol Survey, Louisiana Cooperat Fish & Wildlife Res Unit, Baton Rouge, LA 70803 USA. [Wilson, R. Randy] US Fish & Wildlife Serv, Jackson, MS 39213 USA. RP Valente, JJ (reprint author), USA, Engineer Res & Dev Ctr, Environm Lab, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM Jonathon.J.Valente@gmail.com FU US Fish and Wildlife Service State Wildlife Grant [T-41-R] FX We kindly thank L. Philley, E. Davis, and Grand Cote National Wildlife Refuge for allowing us to use their farms for our study. We also thank J.A. Nyman, P. Stouffer, K. McCarter, and B. Strader for their intellectual contributions. Reviews provided by S. Pierluissi, D. Krementz, P. Leberg, and two anonymous reviewers helped improve this manuscript. Lastly, we thank C. Duplechain, D. Crawford, E. DeLeon, T. Gancos, E. Hunter, J. Unger, J. Keiser, M. Osinskie, J. Russell, R. Villani, H. Gee, B. Pickens, P. Newell, S.R. Kang, and J. Davis for their assistance. This project was funded by US Fish and Wildlife Service State Wildlife Grant T-41-R, which was administered by the Louisiana Department of Wildlife and Fisheries. The use of trade, product, or industry firm names or products is for informative purposes only and does not constitute an endorsement by the US Government or the US Geological Survey. NR 38 TC 0 Z9 1 U1 2 U2 24 PU HUMBOLDT FIELD RESEARCH INST PI STEUBEN PA PO BOX 9, STEUBEN, ME 04680-0009 USA SN 1528-7092 EI 1938-5412 J9 SOUTHEAST NAT JI Southeast. Nat. PD SEP PY 2012 VL 11 IS 3 BP 423 EP 436 DI 10.1656/058.011.0306 PG 14 WC Biodiversity Conservation; Ecology SC Biodiversity & Conservation; Environmental Sciences & Ecology GA 017OJ UT WOS:000309599500006 ER PT J AU Possley, DR Blair, JA Schoenfeld, AJ Lehman, RA Hsu, JR AF Possley, Daniel R. Blair, James A. Schoenfeld, Andrew J. Lehman, Ronald A. Hsu, Joseph R. CA Skeletal Trauma Res Consortium STR TI Complications associated with military spine injuries SO SPINE JOURNAL LA English DT Article DE Spine fracture; Spinal cord injury; Combat trauma; Complication ID CORD MISSILE INJURIES; RETROSPECTIVE ANALYSIS; PENETRATING INJURIES; WAR; INTERVENTION; MANAGEMENT AB BACKGROUND CONTEXT: To assess the presence of complications associated with spine injuries in the Global War on Terror. PURPOSE: To characterize the effect of complications in and around the battlefield during Operation Enduring Freedom and Operation Iraqi Freedom from 2001 to 2009. STUDY DESIGN/SETTING: Retrospective study. PATIENT SAMPLE: American servicemembers sustaining spine injury during combat. METHODS: Extracted medical records of warriors identified by the Joint Theater Trauma Registry from October 2001 to December 2009. Complications were defined as unplanned medical events that required further intervention. Complications were classified as major or minor and further subdivided among groups, including surgical and nonsurgical management, mounted (in an armored vehicle) or dismounted at the time of injury, and blunt or penetrating trauma. RESULTS: Major complications were encountered in 55 servicemembers (9%), and 38 (6%) sustained minor complications. Forty-four percent (n=24) of those with major complications had more than one complication. Eleven servicemembers sustained three or more complications. There were five intraoperative complications, and 50 occurred in the perioperative period. Intraoperative complications included gastrointestinal injury, dural tear, and instrument malposition. Among patients who sustained complications, precipitating spinal injuries occurred primarily in combat (n=43 [78%]) and resulted from blunt (18) or penetrating (25) mechanisms. Complications occurred in 10 (3%) of those treated nonoperatively and 45 (25%) of those receiving surgery. Complications were higher in the dismounted group (80%) as compared with those who were mounted in vehicles at the time of injury (20%). Thirty-five percent (n=24) of surgically treated, dismounted, and penetrating injured servicemembers had complications. Seventeen percent (n=8) of surgically treated and blunt injured mounted servicemembers and 20% (n=13) of dismounted servicemembers had complications. Among the dismounted and nonspinal cord-injured servicemembers, both blunt (p=.002) and penetrating injured (p<.0005) treated with surgery were correlated with complications. Only the dismounted servicemembers with spinal cord injuries because of a penetrating mechanism were also at an increased risk for complications (p<.0005). CONCLUSIONS: Patients treated with surgery appear to be at increased complication risk regardless of the mechanism of injury. Uparmored vehicles may safeguard servicemembers from spine injuries and complications associated with their treatment. This may be reflective of the fact that less severe spinal and concomitant injuries are sustained in the precipitating trauma because of the protection afforded by the vehicle. Dismounted soldiers had more complications in all groups regardless of type of management or injury mechanism. Published by Elsevier Inc. C1 [Possley, Daniel R.; Blair, James A.] San Antonio Mil Med Ctr, Dept Orthopaed Surg, Ft Sam Houston, TX 78234 USA. [Schoenfeld, Andrew J.] William Beaumont Army Med Ctr, Dept Surg, Orthopaed Serv, El Paso, TX 79920 USA. [Lehman, Ronald A.] Walter Reed Mil Med Ctr, Dept Orthopaed & Rehabil, Bethesda, MD 20889 USA. [Hsu, Joseph R.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Possley, DR (reprint author), San Antonio Mil Med Ctr, Dept Orthopaed Surg, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM daniel.possley@amedd.army.mil OI Schoenfeld, Andrew/0000-0002-3691-1215 FU Defense Advanced Research Projects Agency; Defense Medical Research and Development Program; Geneva Foundation FX DRP: Nothing to disclose. JAB: Nothing to disclose. AJS: Nothing to disclose. RAL: Grants: Defense Advanced Research Projects Agency (I, Paid directly to institution/employer), Defense Medical Research and Development Program (H, Paid directly to institution/employer). JRH: Grants: The Geneva Foundation (D, Paid directly to institution). NR 27 TC 2 Z9 2 U1 0 U2 5 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1529-9430 J9 SPINE J JI Spine Journal PD SEP PY 2012 VL 12 IS 9 SI SI BP 756 EP 761 DI 10.1016/j.spinee.2011.10.002 PG 6 WC Clinical Neurology; Orthopedics SC Neurosciences & Neurology; Orthopedics GA 016OF UT WOS:000309527900006 PM 22100207 ER PT J AU Blair, JA Possley, DR Petfield, JL Schoenfeld, AJ Lehman, RA Hsu, JR AF Blair, James A. Possley, Daniel R. Petfield, Joseph L. Schoenfeld, Andrew J. Lehman, Ronald A. Hsu, Joseph R. CA Skeletal Trauma Res Consortium STR TI Military penetrating spine injuries compared with blunt SO SPINE JOURNAL LA English DT Article DE Spine trauma; Blunt; Penetrating; Iraq; Afghanistan ID OPERATION ENDURING FREEDOM; MISSILE INJURIES; IRAQI FREEDOM; WOUNDS AB BACKGROUND CONTEXT: The nature of blunt and penetrating injuries to the spine and spinal column in a military combat setting has been poorly documented in the literature. To date, no study has attempted to characterize and compare blunt and penetrating spine injuries sustained by American servicemembers. PURPOSE: The purpose of this study was to compare the military penetrating spine injuries with blunt spine injuries in the current military conflicts. STUDY DESIGN/SETTING: Retrospective study. PATIENT SAMPLE: All American military servicemembers who have been injured while deployed in Iraq (Operation Iraqi Freedom) and Afghanistan (Operation Enduring Freedom) whose medical data have been entered into the Joint Theater Trauma Registry (JTTR). METHODS: The JTTR was queried for all American servicemembers sustaining an injury to the spinal column or spinal cord while deployed in Iraq or Afghanistan. These data were manually reviewed for relevant information regarding demographics, mechanism of injury, surgical intervention, and neurologic injury. RESULTS: A total of 598 servicemembers sustained injuries to the spine or spinal cord. Isolated blunt injuries were recorded in 396 (66%) servicemembers and 165 (28%) sustained isolating penetrating injuries. Thirty servicemembers (5%) sustained combined blunt and penetrating injuries to the spine. The most commonly documented injuries were transverse process fractures, compression fractures, and burst fractures in the blunt-injured servicemembers versus transverse process fractures, lamina fractures, and spinous process fractures in those injured with a penetrating injury. One hundred four (17%) servicemembers sustained spinal cord injuries, comprising 10% of blunt injuries and 38% of penetrating injuries (p<.0001). Twenty-eight percent (28%) of blunt-injured servicemembers underwent a surgical procedure compared with 41% of those injured by penetrating mechanisms (p=.4). Sixty percent (n=12/20) of blunt-injured servicemembers experienced a neurologic improvement after surgical intervention at follow-up compared with 43% of servicemembers (n=10/23) who underwent a surgical intervention after a penetrating trauma (p=.28). Explosions accounted for 58% of blunt injuries and 47% of penetrating injuries, whereas motor vehicle collisions accounted for 40% of blunt injuries and 2% of penetrating injuries. Concomitant injuries to the abdomen, chest, and head were common in both groups. CONCLUSIONS: Blunt and penetrating injuries to the spinal column and spinal cord occur frequently in the current conflicts in Iraq and Afghanistan. Penetrating injuries result in significantly higher rates of spinal cord injury and trend toward increased rates of operative interventions and decreased neurologic improvement at follow-up. Published by Elsevier Inc. C1 [Blair, James A.; Possley, Daniel R.; Petfield, Joseph L.] San Antonio Mil Med Ctr, Dept Orthopaed & Rehabil, Ft Sam Houston, TX 78234 USA. [Schoenfeld, Andrew J.] William Beaumont Army Med Ctr, Dept Surg, Orthopaed Serv, El Paso, TX 79920 USA. [Lehman, Ronald A.] Walter Reed Natl Mil Med Ctr, Dept Orthopaed & Rehabil, Bethesda, MD 20889 USA. [Hsu, Joseph R.; Skeletal Trauma Res Consortium STR] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Blair, JA (reprint author), San Antonio Mil Med Ctr, Dept Orthopaed & Rehabil, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM james.blair@amedd.army.mil OI Schoenfeld, Andrew/0000-0002-3691-1215 FU DARPA; DMRDP; Geneva Foundation FX JAB: Nothing to disclose. DRP: Nothing to disclose. JLP: Nothing to disclose. AJS: Nothing to disclose. RAL: Grants: DARPA (I, Paid directly to institution/employer), DMRDP (H, Paid directly to institution/employer). JRH: Grants: The Geneva Foundation (D, Paid directly to institution). NR 15 TC 15 Z9 15 U1 0 U2 6 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1529-9430 J9 SPINE J JI Spine Journal PD SEP PY 2012 VL 12 IS 9 SI SI BP 762 EP 768 DI 10.1016/j.spinee.2011.10.009 PG 7 WC Clinical Neurology; Orthopedics SC Neurosciences & Neurology; Orthopedics GA 016OF UT WOS:000309527900007 PM 22100206 ER PT J AU Patzkowski, JC Blair, JA Schoenfeld, AJ Lehman, RA Hsu, JR AF Patzkowski, Jeanne C. Blair, James A. Schoenfeld, Andrew J. Lehman, Ronald A. Hsu, Joseph R. CA Skeletal Trauma Res Consortium STR TI Multiple associated injuries are common with spine fractures during war SO SPINE JOURNAL LA English DT Article DE Spine trauma; Combat trauma; Associated injuries; Polytrauma ID OPERATION ENDURING FREEDOM; IRAQI FREEDOM; TRAUMA; WOUNDS AB BACKGROUND CONTEXT: The nature of concomitant injuries associated with spine fractures in American military personnel engaged in Operation Enduring Freedom (OEF) and Operation Iraqi Freedom (OIF) has been poorly documented in the literature. PURPOSE: To characterize the incidence and epidemiology of associated injuries (AIs) in American military personnel with spine fractures sustained during OEF and OIF from 2001 to 2009. STUDY DESIGN: Retrospective study. PATIENT SAMPLE: American military personnel who were injured in a combat zone and whose medical data were abstracted in the Joint Theater Trauma Registry (JTTR). OUTCOME MEASURES: Not applicable. METHODS: The JTTR was queried using International Statistical Classification of Disease, Ninth Revision codes to identify all individuals who sustained spine injuries in OEF or OIF from October 2001 to December 2009. Medical records of all identified service members were abstracted to ensure accuracy and avoid duplication. Demographic information, including sex, age, and military rank, were obtained for all patients. Information regarding fracture type, spine region, mechanism of injury, and the presence of AIs was collected for all patients. RESULTS: Seventy-eight percent of patients with a spine fracture sustained at least one AI, with an average of 3.4 AIs per patient. Musculoskeletal injuries were most common, followed by chest, abdomen, and traumatic brain injuries. Most patients were injured by an explosive mechanism (62%). Head and face traumas were more common with cervical fractures, chest with thoracic injuries, and abdominopelvic injuries with lumbosacral fractures. Pelvis and acetabulum fractures were common after helicopter crashes, tibia/fibula injuries after explosions, thoracoabdominal injuries after gunshot wounds, and traumatic brain injuries after falls. Most patients (76%) sustained multiple spine fractures. CONCLUSION: Spine fractures sustained in OEF and OIF have high rates of AIs. Musculoskeletal AIs are the most common, but visceral injuries adjacent to the spine fracture frequently occur. Multiple spine injuries are more prevalent after military trauma. Published by Elsevier Inc. C1 [Patzkowski, Jeanne C.; Blair, James A.] San Antonio Mil Med Ctr, Dept Orthopaed & Rehabil, Ft Sam Houston, TX 78234 USA. [Schoenfeld, Andrew J.] William Beaumont Army Med Ctr, Dept Orthoped, El Paso, TX 79920 USA. [Lehman, Ronald A.] Walter Reed Natl Mil Med Ctr, Dept Orthopaed & Rehabil, Bethesda, MD 20889 USA. [Hsu, Joseph R.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Patzkowski, JC (reprint author), San Antonio Mil Med Ctr, Dept Orthopaed & Rehabil, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM jeanne.patzkowski2@amedd.army.mil OI Schoenfeld, Andrew/0000-0002-3691-1215 FU DARPA; DMRDP; Geneva Foundation FX JCP: Nothing to disclose. JAB: Nothing to disclose. AJS: Nothing to disclose. RAL: Grants: DARPA (I, Paid directly to institution/employer), DMRDP (H, Paid directly to institution/employer). JRH: Grants: Geneva Foundation (D, Paid direction to institution/employer). NR 18 TC 6 Z9 6 U1 0 U2 2 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1529-9430 J9 SPINE J JI Spine Journal PD SEP PY 2012 VL 12 IS 9 SI SI BP 791 EP 797 DI 10.1016/j.spinee.2011.10.001 PG 7 WC Clinical Neurology; Orthopedics SC Neurosciences & Neurology; Orthopedics GA 016OF UT WOS:000309527900012 PM 22054909 ER PT J AU Schoenfeld, AJ Lehman, RA Hsu, JR AF Schoenfeld, Andrew J. Lehman, Ronald A., Jr. Hsu, Joseph R. TI Evaluation and management of combat-related spinal injuries: a review based on recent experiences SO SPINE JOURNAL LA English DT Review DE Spine injuries; Combat; United States military; Spinal trauma ID OPERATION-IRAQI-FREEDOM; CERVICAL-SPINE; BLUNT TRAUMA; ENDURING-FREEDOM; METAANALYSIS; WOUNDS AB BACKGROUND CONTEXT: The current approach to the evaluation and treatment of military casualties in the Global War on Terror is informed by medical experience from prior conflicts and combat encounters from the last 10 years. In an effort to standardize the care provided to military casualties in the ongoing conflicts, the Department of Defense (DoD) has published Clinical Practice Guidelines (CPGs) that deal specifically with the combat casualty sustaining a spinal injury. However, the combat experience with spine injuries in the present conflicts remains incompletely described. PURPOSE: To describe the CPGs for the care of the combat casualty with suspected spine injuries and discuss them in light of the published military experience with combat-related spinal trauma. STUDY DESIGN: Literature review. METHODS: A literature review was conducted regarding published works that discussed the incidence, epidemiology, and management of combat-related spinal trauma. The CPGs, established by the DoD, are discussed in light of actual military experiences with spine trauma, the present situation in the forward surgical teams and combat support hospitals treating casualties in theater, and recent publications in the field of spine surgery. RESULTS: In the conventional wars fought by the United States between 1950 and 1991 (Korea, Vietnam, Gulf War I), the incidence of spine injuries remained close to 1% of all combat casualties. However, in the Global War on Terror, the enemy has relied on implements of asymmetric warfare, including sniper attacks, ambush, roadside bombs, and improvised explosive devices. The increase in explosive mechanisms of injury has elevated the number of soldiers exposed to blunt force trauma and, consequently, recent publications reported the highest incidence of combat-related spinal injuries in American military history. Wounded soldiers are expeditiously evacuated through the echelons of care but typically do not receive surgical management in theater. The current CPGs for the care of soldiers with combat-related spinal injuries should be re-examined in light of data regarding the increasing number of spine injuries, new injury patterns, such as lumbosacral dissociation and low lumbar burst fractures, and recent reports within the field of spine surgery as a whole. CONCLUSIONS: American and coalition forces are sustaining the highest spine combat casualty rates in recorded history and previously unseen injuries are being encountered with increased frequency. While the CPGs provide useful direction in terms of the evaluation and management of combat casualties with spine injuries, such recommendations may warrant periodic re-evaluation in light of recent combat experiences and evolving scientific evidence within the spine literature. Published by Elsevier Inc. C1 [Schoenfeld, Andrew J.] 115th Combat Support Hosp, Dept Orthopaed Surg, El Paso, TX 79920 USA. [Schoenfeld, Andrew J.] William Beaumont Army Med Ctr, El Paso, TX 79920 USA. [Lehman, Ronald A., Jr.] Walter Reed Natl Mil Med Ctr, Integrated Dept Orthopaed Surg & Rehabil, Bethesda, MD 20889 USA. [Hsu, Joseph R.] USA, Dept Orthopaed Surg, Inst Surg Res, San Antonio Mil Med Ctr, San Antonio, TX 78234 USA. RP Schoenfeld, AJ (reprint author), 115th Combat Support Hosp, Dept Orthopaed Surg, 5005 N Piedras St, El Paso, TX 79920 USA. EM ajschoen@neoucom.edu OI Schoenfeld, Andrew/0000-0002-3691-1215 FU DARPA; DMRDP FX AJS: Nothing to disclose; RAL: Grants: DARPA (I, Paid directly to institution/employer), DMRDP (H, Paid directly to institution/employer); JRH: Nothing to disclose. NR 22 TC 9 Z9 9 U1 0 U2 5 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1529-9430 J9 SPINE J JI Spine Journal PD SEP PY 2012 VL 12 IS 9 SI SI BP 817 EP 823 DI 10.1016/j.spinee.2011.04.028 PG 7 WC Clinical Neurology; Orthopedics SC Neurosciences & Neurology; Orthopedics GA 016OF UT WOS:000309527900016 PM 21640658 ER PT J AU Blair, JA Patzkowski, JC Schoenfeld, AJ Rivera, JDC Grenier, ES Lehman, RA Hsu, JR AF Blair, James A. Patzkowski, Jeanne C. Schoenfeld, Andrew J. Rivera, Jessica D. Cross Grenier, Eric S. Lehman, Ronald A. Hsu, Joseph R. CA Skeletal Trauma Res Consortium STR TI Are spine injuries sustained in battle truly different? SO SPINE JOURNAL LA English DT Review DE Spine trauma; Spinal cord injury; Battle injury; Nonbattle injury; Military ID OPERATION IRAQI FREEDOM; ENDURING FREEDOM; CORD INJURIES; TRAUMA CENTER; EXPERIENCE; WOUNDS; COLUMN AB BACKGROUND CONTEXT: The severity and prognosis of combat-related injuries to the spine and spine injuries sustained unrelated to direct combat have not been previously compared. Differences may have implications on tactics, treatment strategies, and directions for future research. PURPOSE: Compare the severity and prognosis of battle and nonbattle injuries to the spine. STUDY DESIGN: Retrospective study. PATIENT SAMPLE: American military personnel who were injured in a combat zone and whose medical data were abstracted in the Joint Theater Trauma Registry (JTTR). METHODS: The JTTR was queried using International Statistical Classification of Diseases, Ninth Revision codes to identify all individuals who sustained battle and nonbattle injuries to the neck, back, spinal column, or spinal cord in Operation Iraqi Freedom or Operation Enduring Freedom from October 2001 to December 2009. Medical records of all identified servicemembers were individually reviewed. Demographic information, including sex, age, military rank, date of injury, and final disposition, was obtained for all patients. Spinal injuries were categorized according to anatomic location, associated neurologic involvement, precipitating mechanism of injury (MOI), and concomitant wounds. These data points were compared for the groups battle spine injuries (BSIs) and nonbattle spine injuries (NBSIs). RESULTS: Five hundred two servicemembers sustained a total of 1,834 battle injuries to the spinal column, including 1,687 fractures (92%), compared with 92 servicemembers sustaining 267 nonbattle spinal column injuries, with 241 (90%) fractures. Ninety-one BSI servicemembers (18% of patients) sustained spinal cord injuries (SCIs) with 41 (45%) complete SCIs, compared with 13 (14% of patients) nonbattle SCIs with six (46.2%) complete injuries (p=.92). The reported MOI for 335 BSI servicemembers (66.7%) was an explosion compared with one NBSI explosive injury. Eighty-four patients (17%) sustained gunshot wounds (GSWs) in battle compared with five (5.2%) nonbattle GSWs. Fifteen patients (3.0%) sustained a battle-related fall compared with 29 (30%) nonbattle-related falls. Battle spine injury servicemembers underwent significantly higher rates of surgical interventions (p<.0001), were injured by high-energy injury mechanisms at a significantly greater rate (p<.0001), and demonstrated a trend toward lower neurologic recovery rates after SCI (p=.16). CONCLUSIONS: Battle spine injury and NBSI are separate entities that may ultimately have disparate long-term prognoses. Nonbattle spine injury patients, although having similar MOIs compared with civilian spinal trauma, maintain a different patient demographic. Further research must be directed at accurately quantifying the long-term disabilities of all spine injuries sustained in a combat theater, whether they are the result of battle or not. Published by Elsevier Inc. C1 [Blair, James A.; Patzkowski, Jeanne C.; Rivera, Jessica D. Cross; Grenier, Eric S.] San Antonio Mil Med Ctr, Dept Orthopaed & Rehabil, Ft Sam Houston, TX 78234 USA. [Schoenfeld, Andrew J.] William Beaumont Army Med Ctr, Dept Surg, Orthopaed Serv, El Paso, TX 79920 USA. [Lehman, Ronald A.] Walter Reed Natl Mil Med Ctr, Dept Orthopaed & Rehabil, Bethesda, MD 20889 USA. [Hsu, Joseph R.; Skeletal Trauma Res Consortium STR] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Blair, JA (reprint author), San Antonio Mil Med Ctr, Dept Orthopaed & Rehabil, Ft Sam Houston, TX 78234 USA. EM james.blair@amedd.army.mil OI Schoenfeld, Andrew/0000-0002-3691-1215 FU Defense Advanced Research Projects Agency; Defense Medical Research and Development Program FX JAB: Nothing to disclose. JCP: Nothing to disclose. AJS: Nothing to disclose. JDCR: Nothing to disclose. ESG: Nothing to disclose. RAL: Grants: Defense Advanced Research Projects Agency (I, Paid directly to institution/employer), Defense Medical Research and Development Program (H, Paid directly to institution/employer). JRH: The Geneva Foundation (D, Paid directly to institution). NR 21 TC 14 Z9 14 U1 0 U2 5 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1529-9430 J9 SPINE J JI Spine Journal PD SEP PY 2012 VL 12 IS 9 SI SI BP 824 EP 829 DI 10.1016/j.spinee.2011.09.012 PG 6 WC Clinical Neurology; Orthopedics SC Neurosciences & Neurology; Orthopedics GA 016OF UT WOS:000309527900017 PM 22000726 ER PT J AU Possley, DR Blair, JA Freedman, BA Schoenfeld, AJ Lehman, RA Hsu, JR AF Possley, Daniel R. Blair, James A. Freedman, Brett A. Schoenfeld, Andrew J. Lehman, Ronald A. Hsu, Joseph R. CA Skeletal Trauma Res Consortium STR TI The effect of vehicle protection on spine injuries in military conflict SO SPINE JOURNAL LA English DT Review DE Spine fracture; Spinal cord injury; Combat trauma; Mode of transportation ID OPERATION-IRAQI-FREEDOM; ENDURING-FREEDOM; COMBAT CASUALTIES; BODY ARMOR; FRACTURES; TRAUMA; CLASSIFICATION; BATTLEFIELD AB BACKGROUND CONTEXT: To evaluate the effect of critical time periods in vehicle protection on spine injuries in the Global War on Terror. PURPOSE: To characterize the effect of method of movement on and around the battlefield during Operation Enduring Freedom and Operation Iraqi Freedom from 2001 to 2009 in terms of its impact on the incidence and severity of spinal fractures sustained in combat. STUDY DESIGN/SETTING: Retrospective study. PATIENT SAMPLE: Mounted and dismounted American servicemembers who were injured during combat. METHODS: Extracted medical records of servicemembers identified in the Joint Theater Trauma Registry from October 2001 to December 2009. Methods of movement were defined as mounted or dismounted. Two time periods were compared. Cohorts were created for 2x2 analysis based on method of movement and the time period in which the injury occurred. Time period 1 and 2 were separated by April 1, 2007, which correlates with the initial fielding of the modern class of uparmored fighting vehicles with thickened underbelly armor and a V-shaped hull. Our four comparison groups were Dismounted in Time Period 1 (D1), Dismounted in Time Period 2 (D2), Mounted in Time Period 1 (M1), and Mounted in Time Period 2 (M2). RESULTS: In total, 1,819 spine fractures occurred over the entire study period. Four hundred seventy-two fractures (26%) were sustained in 145 servicemembers who were mounted at the time of injury, and 1,347 (74%) were sustained by 404 servicemembers who were dismounted (p<.0005). The incidence of fractures in the dismounted cohort (D1+D2) was significantly higher than in the mounted cohort (M1+M2) in both time periods (D1 vs. M1, 13.75 vs. 3.95/10,000 warrior-years [p<.001] and D2 vs. M2, 11.15 vs. 4.89/10,000 warrior-years [p<.0001]). In both the mounted and dismounted groups, the thoracolumbar (TL) junction was the most common site of injury (36.1%). Fractures to the TL junction (T10-L3) increased significantly from Time Period 1 to 2 (34% vs. 40% of all fractures, respectively, p=.03). Thoracolumbar fractures were significantly more severe in that there were more Arbeitsgemeinschaft fur Osteosynthesefragen/Magerl Type A injuries versus all TL fractures, 1.75 versus 2.68/10,000 or 27% of all spine fractures in Time Period 1 versus 40% in Time Period 2 (p=.007). Furthermore, there were significantly fewer minor fractures (spinous process and transverse process fractures) (p<.0001). In Time Period 2, significantly more TL spine fractures were classified as major fractures, according to the Denis classification system, in both the mounted and dismounted groups; M1 group, 61 of 226 (27%) versus the M2 group, 86 of 246 (34%) (p<.0005) and 173 of 786 (22%) in the D1 group versus 193 of 561 (34%) in the D2 group. The spinal cord injury (SCI) incidence did not change in the mounted groups in Time Period 1 (7 of 71, 9.9%) versus Time Period 2 (7 of 74, 9.5%) (p=.935). In the dismounted groups, SCI actually decreased from D1 (55 of 228, 24%) to D2 (28 of 176, 16%) (p=.0428). CONCLUSIONS: The incidence of spine fractures and SCI is significantly higher in dismounted operations. The data suggest that current uparmored vehicles convey greater protection against spinal fracture compared with dismounted operations in which servicemembers are engaged on foot, outside their vehicles. The TL junction is at greatest risk for spine fractures sustained in mounted and dismounted combat operations. Recently, the incidence of TL fractures, especially severe fractures, has significantly increased in mounted operations. Although there has been an increased incidence of TL spine fractures, in context of the number of servicemembers deployed in support of Operation Enduring Freedom/Operation Iraqi Freedom, these severe fractures still represent a relatively rare event. Published by Elsevier Inc. C1 [Possley, Daniel R.; Blair, James A.] San Antonio Mil Med Ctr, Dept Orthopaed Surg, Ft Sam Houston, TX 78234 USA. [Freedman, Brett A.] Landstuhl Reg Med Ctr, Dept Orthopaed Surg, Landstuhl, Germany. [Schoenfeld, Andrew J.] William Beaumont Army Med Ctr, Dept Surg, Orthopaed Serv, El Paso, TX 79920 USA. [Lehman, Ronald A.] Walter Reed Mil Med Ctr, Dept Orthopaed & Rehabil, Bethesda, MD 20889 USA. [Hsu, Joseph R.] USA, Inst Surg Res, Ft Sam Houston, TX 78261 USA. RP Possley, DR (reprint author), San Antonio Mil Med Ctr, Dept Orthopaed Surg, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM Daniel.Possley@amedd.army.mil OI Schoenfeld, Andrew/0000-0002-3691-1215 FU DARPA; DMRDP; Geneva Foundation; Combat Casualty Care Research Program; Major Extremity Research Consortium FX DRP: Nothing to disclose. JAB: Nothing to disclose. BAF: Relationships Outside the One-Year Requirement: Medtronic, Inc (Speaking and/or Teaching Arrangement, B). AJS: Nothing to disclose. RAL: Grants: DARPA (I, Paid directly to institution/employer), DMRDP (H, Paid directly to institution/employer). JRH: Research Support: The Geneva Foundation (E, Paid directly to institution), The Combat Casualty Care Research Program (F, Paid directly to institution), The Major Extremity Research Consortium (F, Paid directly to institution). NR 27 TC 9 Z9 10 U1 0 U2 6 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1529-9430 J9 SPINE J JI Spine Journal PD SEP PY 2012 VL 12 IS 9 SI SI BP 843 EP 848 DI 10.1016/j.spinee.2011.10.007 PG 6 WC Clinical Neurology; Orthopedics SC Neurosciences & Neurology; Orthopedics GA 016OF UT WOS:000309527900020 PM 22177925 ER PT J AU Rao, SS Stesmans, A van Tol, J Kosynkin, DV Higginbotham-Duque, A Lu, W Sinitskii, A Tour, JM AF Rao, Singamaneni S. Stesmans, Andre van Tol, Johan Kosynkin, Dmitry V. Higginbotham-Duque, A. Lu, Wei Sinitskii, Alexander Tour, James. M. TI Spin Dynamics and Relaxation in Graphene Nanoribbons: Electron Spin Resonance Probing SO ACS NANO LA English DT Article DE electron spin relaxation rate; graphene nanoribbons; tunneling level states; electron spin resonance; edge spin ID CARBON NANOTUBES; LATTICE-RELAXATION; TEMPERATURE; DEFECTS AB Here we report the results of a multifrequency (similar to 9, 20, 34, 239.2, and 336 GHz) variable-temperature continuous wave (cw) and X-band (similar to 9 GHz) pulse electron spin resonance (ESR) measurement performed at cryogenic temperatures on potassium split graphene nanoribbons (GNRs). Important experimental findings include the following: (a) The multifrequency cw ESR data infer the presence of only carbon-related paramagnetic nonbonding states, at any measured temperature, with the g value independent of microwave frequency and temperature. (b) A linear broadening of the ESR signal as a function of microwave frequency is noticed. The observed linear frequency dependence of ESR signal width points to a distribution of g factors causing the non-Lorentzian line shape, and the g broadening contribution is found to be very small. (c) The ESR process is found to be characterized by slow and fast components, whose temperature dependences could be well described by a tunneling level state model. This work not only could help in advancing the present fundamental understanding on the edge spin (or magnetic)-based properties of GNRs but also pave the way to GNR-based spin devices. C1 [Rao, Singamaneni S.; Stesmans, Andre] Katholieke Univ Leuven, Semicond Phys Lab, Inst Nanoscale Phys & Chem, INPAC, B-3001 Louvain, Belgium. [van Tol, Johan] Florida State Univ, Ctr Interdisciplinary Magnet Resonance, Natl High Magnet Field Lab, Tallahassee, FL 32310 USA. [Kosynkin, Dmitry V.; Higginbotham-Duque, A.; Lu, Wei; Sinitskii, Alexander; Tour, James. M.] Rice Univ, Dept Chem, Houston, TX 77005 USA. [Tour, James. M.] Rice Univ, Dept Mech Engn & Mat Sci, Houston, TX 77005 USA. [Tour, James. M.] Rice Univ, Smalley Inst Nanoscale Sci & Technol, Houston, TX 77005 USA. RP Rao, SS (reprint author), Army Res Off, Div Mat Sci, Res Triangle Pk, NC 27709 USA. EM ssingam@ncsu.edu RI van Tol, Johan/G-4190-2011; Lu, Wei /D-1751-2012; Sinitskii, Alexander/J-6619-2015; OI van Tol, Johan/0000-0001-6972-2149; Lu, Wei /0000-0003-4504-7083; Sinitskii, Alexander/0000-0002-8688-3451; Tour, James/0000-0002-8479-9328 FU NSF [DMR-0654118]; Air Force Office of Scientific Research [FA9550-09-1-0581]; Office of Naval Research MURI Graphene program; State of Florida FX The National High Magnetic Field Laboratory is supported by NSF Cooperative Agreement No. DMR-0654118, and by the State of Florida. The work at Rice University was supported by the Air Force Office of Scientific Research FA9550-09-1-0581 and the Office of Naval Research MURI Graphene program. NR 35 TC 15 Z9 15 U1 1 U2 44 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1936-0851 J9 ACS NANO JI ACS Nano PD SEP PY 2012 VL 6 IS 9 BP 7615 EP 7623 DI 10.1021/nn302745x PG 9 WC Chemistry, Multidisciplinary; Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary SC Chemistry; Science & Technology - Other Topics; Materials Science GA 009QP UT WOS:000309040600008 PM 22901098 ER PT J AU Zamolo, VA Valenti, G Venturelli, E Chaloin, O Marcaccio, M Boscolo, S Castagnola, V Sosa, S Berti, F Fontanive, G Poli, M Tubaro, A Bianco, A Paolucci, F Prato, M AF Zamolo, Valeria Anna Valenti, Giovanni Venturelli, Enrica Chaloin, Olivier Marcaccio, Massimo Boscolo, Sabrina Castagnola, Valentina Sosa, Silvio Berti, Federico Fontanive, Giampaolo Poli, Mark Tubaro, Aurelia Bianco, Alberto Paolucci, Francesco Prato, Maurizio TI Highly Sensitive Electrochemiluminescent Nanobiosensor for the Detection of Palytoxin SO ACS NANO LA English DT Article DE biosensor; palytoxin; carbon nanotubes; antibody; electrochemiluminescence; shellfish ID WALLED CARBON NANOTUBES; SURFACES AB Marine toxins appear to be increasing in many areas of the world. An emerging problem in the Mediterranean Sea is represented by palytoxin (PITX), one of the most potent marine toxins, frequently detected in seafood. Due to the high potential for human toxicity of PITX, there is a strong and urgent need for sensitive methods toward its detection and quantification. We have developed an ultrasensitive electrochemiluminescence-based sensor for the detection of PITX, taking advantage of the specificity provided by anti-PITX antibodies, the good conductive properties of carbon nanotubes, and the excellent sensitivity achieved by a luminescence-based transducer. The sensor was able to produce a concentration-dependent light signal, allowing PITX quantification in mussels, with a limit of quantification (LOQ = 2.2 mu g/kg of mussel meat) more than 2 orders of magnitude more sensitive than that of the commonly used detection techniques, such as LC-MS/MS. C1 [Sosa, Silvio; Tubaro, Aurelia] Univ Trieste, Dept Life Sci, I-34127 Trieste, Italy. [Zamolo, Valeria Anna; Berti, Federico; Fontanive, Giampaolo; Prato, Maurizio] Univ Trieste, Ctr Excellence Nanostruct Mat, Dept Chem & Pharmaceut Sci, I-34127 Trieste, Italy. [Zamolo, Valeria Anna; Berti, Federico; Fontanive, Giampaolo; Prato, Maurizio] Univ Trieste, INSTM, Unit Trieste, I-34127 Trieste, Italy. [Valenti, Giovanni; Marcaccio, Massimo; Castagnola, Valentina; Paolucci, Francesco] Univ Bologna, Dept Chem G Ciamidan, I-40126 Bologna, Italy. [Venturelli, Enrica; Chaloin, Olivier; Bianco, Alberto] CNRS, Lab Immunol & Chim Therapeut, Inst Biol Mol & Cellulaire, F-67000 Strasbourg, France. [Boscolo, Sabrina] Univ Trieste, Dept Life Sci, I-34127 Trieste, Italy. [Poli, Mark] USA, Med Res Inst Infect Dis, Ft Detrick, MD 21701 USA. RP Tubaro, A (reprint author), Univ Trieste, Dept Life Sci, Via A Valerio 6, I-34127 Trieste, Italy. EM tubaro@units.it; a.bianco@ibmc-cnrs.unistra.fr; francesco.paolucci@unibo.it; prato@units.it RI Prato, Maurizio/G-7067-2012; OI Prato, Maurizio/0000-0002-8869-8612; VALENTI, GIOVANNI/0000-0002-6223-2072 FU Regione Friuli Venezia-Giulia, Direzione Risorse Rurali, Agroalimentari e Forestali (Progetto "Kit e biosensori di elevata sensibilita per la determinazione delle tossine di alghe nelle acque e nei prodotti ittici del Friuli Venezia Giulia - Senstox"); European Union [HEALTH-2007-201587]; CNRS; University of Trieste, the Italian Ministry of Education MIUR [Cofin Prot. 20085M27SS, Firb RBIN04HC3S] FX This work was supported by Regione Friuli Venezia-Giulia, Direzione Risorse Rurali, Agroalimentari e Forestali (Progetto "Kit e biosensori di elevata sensibilita per la determinazione delle tossine di alghe nelle acque e nei prodotti ittici del Friuli Venezia Giulia - Senstox"), and the European Union FP7 ANTICARB (HEALTH-2007-201587) program. Support is also acknowledged by the CNRS and the University of Trieste, the Italian Ministry of Education MIUR (Cofin Prot. 20085M27SS and Firb RBIN04HC3S). TEM images were recorded at the RIO Microscopy Facility Platform of Esplanade Campus (Strasbourg, France) and at the Electron Microscopy Facility of the University of Trieste (with the assistance of Mr. Claudio Gamboz). The authors wish to thank also Prof. G. Honsell (University of Udine) and Dr. M. Pelin (University of Trieste) for their assistance and discussions. NR 30 TC 40 Z9 40 U1 7 U2 73 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1936-0851 J9 ACS NANO JI ACS Nano PD SEP PY 2012 VL 6 IS 9 BP 7989 EP 7997 DI 10.1021/nn302573c PG 9 WC Chemistry, Multidisciplinary; Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary SC Chemistry; Science & Technology - Other Topics; Materials Science GA 009QP UT WOS:000309040600049 PM 22913785 ER PT J AU Cao, XY Pignatello, JJ Li, Y Lattao, C Chappell, MA Chen, N Miller, LF Mao, JD AF Cao, Xiaoyan Pignatello, Joseph J. Li, Yuan Lattao, Charisma Chappell, Mark A. Chen, Na Miller, Lesley F. Mao, Jingdong TI Characterization of Wood Chars Produced at Different Temperatures Using Advanced Solid-State C-13 NMR Spectroscopic Techniques SO ENERGY & FUELS LA English DT Article ID NUCLEAR-MAGNETIC-RESONANCE; BLACK CARBON; CARBONIZATION TEMPERATURE; ORGANIC-MATTER; CHARCOAL; PYROLYSIS; BIOMASS; ACID; QUANTIFICATION; AROMATICITY AB Temperature is one of the controlling factors determining the chemical structure of char. We employed advanced solid-state C-13 NMR techniques to characterize maple wood and its chars produced under wN(2) at temperatures from 300 to 700 degrees C. Our results indicated that 300 degrees C char was primarily composed of residues of biopolymers such as lignin and cellulose. Carbohydrates are completely lost for char prepared at 350 degrees C. At 400 degrees C, the char lost most of the ligno-cellulosic features and consisted predominantly of aromatic structures. By 500 degrees C, sp(3)-hybridized carbon had all but disappeared. Protonated aromatic carbons increased up to 400 degrees C chars but then decreased. Aromatic C-O groups decreased, whereas nonprotonated aromatic carbons, especially bridgehead carbons, increased as temperature increased. The minimum aromatic cluster sizes estimated from spectral analysis increased from 8 carbons in 300 degrees C char, to 20, 18, 40, 64, and 76 carbons, respectively, in 350 degrees C, 400 degrees C, 500 degrees C, 600 degrees C, and 700 degrees C chars. H-1-C-13 long-range dipolar dephasing displayed the same increasing trend of aromatic cluster sizes of wood chars with increasing temperature. We show for the first time quantitative changes of different aromatic C forms and aromatic cluster size as a function of heat treatment temperature. C1 [Cao, Xiaoyan; Li, Yuan; Chen, Na; Mao, Jingdong] Old Dominion Univ, Dept Chem & Biochem, Norfolk, VA 23529 USA. [Pignatello, Joseph J.; Lattao, Charisma] Connecticut Agr Expt Stn, Dept Environm Sci, New Haven, CT 06504 USA. [Chappell, Mark A.; Miller, Lesley F.] USA, Corps Engineers, Environm Lab, Vicksburg, MS 39180 USA. RP Mao, JD (reprint author), Old Dominion Univ, Dept Chem & Biochem, 4541 Hampton Blvd, Norfolk, VA 23529 USA. EM jmao@odu.edu RI Cao, Xiaoyan/E-3492-2012 OI Cao, Xiaoyan/0000-0001-7571-6482 FU National Science Foundation [CBET-0853950, CBET-0853682] FX We thank the National Science Foundation (CBET-0853950 and CBET-0853682) for the support of this research. NR 47 TC 31 Z9 31 U1 4 U2 74 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0887-0624 EI 1520-5029 J9 ENERG FUEL JI Energy Fuels PD SEP PY 2012 VL 26 IS 9 BP 5983 EP 5991 DI 10.1021/ef300947s PG 9 WC Energy & Fuels; Engineering, Chemical SC Energy & Fuels; Engineering GA 006YP UT WOS:000308856000068 ER PT J AU Foley, DH Wilkerson, RC Dornak, LL Pecor, DB Nyari, AS Rueda, LM Long, LS Richardson, JH AF Foley, Desmond H. Wilkerson, Richard C. Dornak, L. Lynnette Pecor, David B. Nyari, Arpad S. Rueda, Leopoldo M. Long, Lewis S. Richardson, Jason H. TI SandflyMap: leveraging spatial data on sand fly vector distribution for disease risk assessments SO GEOSPATIAL HEALTH LA English DT Article DE database; distribution; SandflyMap; VectorMap; leishmaniasis; georeferencing; geographical information system AB We feature SandflyMap (www.sandflymap.org), a new map service within VectorMap (www.vectormap.org) that allows free public online access to global sand fly, tick and mosquito collection records and habitat suitability models. Given the short home range of sand flies, combining remote sensing and collection point data give a powerful insight into the environmental determinants of sand fly distribution. SandflyMap is aimed at medical entomologists, vector disease control workers, public health officials and health planners. Data are checked for geographical and taxonomic errors, and are comprised of vouchered specimen information, and both published and unpublished observation data. SandflyMap uses Microsoft Silverlight and ESRI's ArcGIS Server 10 software platform to present disease vector data and relevant remote sensing layers in an online geographical information system format. Users can view the locations of past vector collections and the results of models that predict the geographic extent of individual species. Collection records are searchable and downloadable, and Excel collection forms with drop down lists, and Excel charts to country, are available for data contributors to map and quality control their data. SandflyMap makes accessible, and adds value to, the results of past sand fly collecting efforts. We detail the workflow for entering occurrence data from the literature to SandflyMap, using an example for sand flies from South America. We discuss the utility of SandflyMap as a focal point to increase collaboration and to explore the nexus between geography and vector-borne disease transmission. C1 [Foley, Desmond H.; Wilkerson, Richard C.; Dornak, L. Lynnette; Pecor, David B.; Nyari, Arpad S.; Rueda, Leopoldo M.; Long, Lewis S.; Richardson, Jason H.] Walter Reed Army Inst Res, Entomol Branch, Silver Spring, MD 20910 USA. RP Foley, DH (reprint author), Smithsonian Inst, Walter Reed Army Inst Res, MSC MRC534,4210 Silver Hill Rd, Suitland, MD 20746 USA. EM foleydes@si.edu RI Richardson, Jason/A-9441-2011; Valle, Ruben/A-7512-2013 FU Global Emerging Infections Surveillance and Response System, a Division of the Armed Forces Health Surveillance Center; Global Biodiversity Information Facility FX Funding for this work was provided by the Global Emerging Infections Surveillance and Response System, a Division of the Armed Forces Health Surveillance Center, and from the Global Biodiversity Information Facility. This research was performed under a Memorandum of Understanding between the Walter Reed Army Institute of Research and the Smithsonian Institution, with institutional support provided by both organizations. The opinions and assertions contained herein are those of the authors and are not to be construed as official or reflecting the views of the Department of the Army or the Department of Defense. NR 9 TC 5 Z9 5 U1 1 U2 6 PU UNIV NAPLES FEDERICO II PI NAPLES PA FAC VET MED, DEP PATHOLOGY & ANIMAL HEALTH, VET PARASITOLOGY, VIA DELLA VETERINARIA 1, NAPLES, 80137, ITALY SN 1827-1987 J9 GEOSPATIAL HEALTH JI Geospatial Health PD SEP PY 2012 VL 6 IS 3 SI SI BP S25 EP S30 PG 6 WC Health Care Sciences & Services; Public, Environmental & Occupational Health SC Health Care Sciences & Services; Public, Environmental & Occupational Health GA 011JC UT WOS:000309159900005 PM 23032280 ER PT J AU Bogetti, TA Staniszewski, J Burns, BP Hoppel, CPR Gillespie, JW Tierney, J AF Bogetti, Travis A. Staniszewski, Jeffrey Burns, Bruce P. Hoppel, Christopher P. R. Gillespie, John W., Jr. Tierney, John TI Predicting the nonlinear response and progressive failure of composite laminates under tri-axial loading SO JOURNAL OF COMPOSITE MATERIALS LA English DT Article DE Maximum strain; three-dimensional progressive ply failure; nonlinear response; through-thickness; failure; envelope ID ELASTIC-CONSTANTS; CAPABILITIES; STIFFNESS; EXERCISE; CRACKING AB As a part of the Second World-Wide Failure Exercise, a three-dimensional nonlinear maximum progressive strain model, based on laminate analysis, is employed to make blind predictions for 12 test cases representing failure envelopes and stress strain curves for isotropic, unidirectional, and multidirectional composite laminates. This approach allows for redistribution of ply stresses and differentiation of the various potential modes of failure. These cases include initial and final ply failure envelopes under tri-axial loading, as well as 3 cases, requiring nonlinear stress-strain analysis. Comparison of predictions with actual experimental data will be made in Part B of the Second World-Wide Failure Exercise. C1 [Bogetti, Travis A.] USA, Res Lab, RDRL WMM B, Aberdeen Proving Ground, MD 21005 USA. [Gillespie, John W., Jr.] Univ Delaware, Ctr Composite Mat, Dept Civil & Environm Engn, Newark, DE 19716 USA. [Gillespie, John W., Jr.] Univ Delaware, Dept Mat Sci & Engn, Newark, DE 19716 USA. RP Bogetti, TA (reprint author), USA, Res Lab, RDRL WMM B, Aberdeen Proving Ground, MD 21005 USA. EM travis.a.bogetti.civ@mail.mil NR 33 TC 7 Z9 7 U1 1 U2 11 PU SAGE PUBLICATIONS LTD PI LONDON PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND SN 0021-9983 J9 J COMPOS MATER JI J. Compos Mater. PD SEP PY 2012 VL 46 IS 19-20 SI SI BP 2443 EP 2459 DI 10.1177/0021998312449889 PG 17 WC Materials Science, Composites SC Materials Science GA 015EA UT WOS:000309427100010 ER PT J AU McPhatter, LP Mahmood, F Debboun, M AF McPhatter, Lee P. Mahmood, Farida Debboun, Mustapha TI SURVEY OF MOSQUITO FAUNA IN SAN ANTONIO, TEXAS SO JOURNAL OF THE AMERICAN MOSQUITO CONTROL ASSOCIATION LA English DT Article DE Mosquito fauna; San Antonio; Aedes vexans; Aedes sollicitans; Culex tarsalis AB A faunal survey of mosquitoes was conducted in 2008, 2009, and 2010 at various trapping locations throughout the city of San Antonio, TX. A total of 22,739 mosquitoes representing 41 species in 8 genera were collected during this study. The most prevalent mosquito species collected were Aedes vexans (25%). Ae. sollicitans (14%). Culex tarsalis (13.5%), and Cx. erraticus (11%). Four mosquito species (Ae. bimaculatus, Anopheles freeborni, Cx. decimator, and Psorophora horrida) not previously recorded in this area were collected, whereas several species historically occurring in San Antonio were not collected during this survey. C1 [McPhatter, Lee P.; Mahmood, Farida] USA, Publ Hlth Command Reg S, Ft Sam Houston, TX 78234 USA. [Debboun, Mustapha] USA, Dept Prevent Hlth Serv, Med Dept Ctr & Sch, Acad Hlth Sci, Ft Sam Houston, TX 78234 USA. RP McPhatter, LP (reprint author), USA, Publ Hlth Command Reg S, Ft Sam Houston, TX 78234 USA. NR 29 TC 1 Z9 1 U1 2 U2 7 PU AMER MOSQUITO CONTROL ASSOC PI MOUNT LAUREL PA 15000 COMMERCE PARKWAY, SUITE C, MOUNT LAUREL, NJ 08054 USA SN 8756-971X J9 J AM MOSQUITO CONTR JI J. Am. Mosq. Control Assoc. PD SEP PY 2012 VL 28 IS 3 BP 240 EP 247 PG 8 WC Entomology SC Entomology GA 013HH UT WOS:000309296000012 PM 23833905 ER PT J AU Lee, RML Lam-Phua, SG Tan, WCH Pang, SC Vythilingam, I Ng, LC Rueda, LM AF Lee, Ruth Mee Lian Lam-Phua, Sai Gek Tan, Wilson Cheong Huat Pang, Sook Cheng Vythilingam, Indra Ng, Lee Ching Rueda, Leopoldo M. TI MOSQUITO FAUNA OF UBIN ISLAND, SINGAPORE SO JOURNAL OF THE AMERICAN MOSQUITO CONTROL ASSOCIATION LA English DT Article DE Diptera; Culicidae; mosquitoes; Ubin; Singapore AB We report the mosquito species and their distribution records for Ubin Island, Singapore, based on our field collections in February 2010, routine adult and larval surveys from 1993 to 2009 by Singapore operational officers, and accessioned specimens deposited in the Environmental Health Institute, Singapore, and the US National Museum of Natural History, Washington, DC. A total of 25 species and 6 unidentified species belonging to 9 genera (Aedes, Anopheles, Armigeres, Coquillettidia, Culex, Lutzia, Mansonia, Uranotaenia, and Verrallina) were identified and recorded from Ubin Island, based on specimens collected from 1993 to 2010. C1 [Lee, Ruth Mee Lian; Lam-Phua, Sai Gek; Tan, Wilson Cheong Huat; Pang, Sook Cheng; Vythilingam, Indra; Ng, Lee Ching] Natl Environm Agcy, Environm Hlth Inst, Singapore 138667, Singapore. [Rueda, Leopoldo M.] Walter Reed Army Inst Res, Walter Reed Biosystemat Unit, Entomol Branch, Silver Spring, MD 20910 USA. [Vythilingam, Indra] Univ Malaya, Fac Med, Parasitol Dept, Kuala Lumpur 50603, Malaysia. RP Rueda, LM (reprint author), Smithsonian Inst, Walter Reed Biosystemat Unit, MSC MRC 534,4210 Silver Hill Rd, Suitland, MD 20746 USA. RI Vythilingam, Indra/Q-5019-2016 FU Singapore EHI FX We would like to thank researchers of the Singapore EHI and field officers of the Environmental Health Department for their help in collecting mosquito specimens, especially C. S. B. Lee, N. Maideen, and O. Mohd Ali. We also thank C. S. Chong, B. A. Harrison, Y. M. Huang, and B. P. Rueda for reviewing the manuscript. Funding for this work was provided by the Singapore EHI. The opinions and assertions contained herein are those of the authors and are not to be construed as official or reflecting the views of the US Department of the Army or the US Department of Defense. NR 13 TC 1 Z9 1 U1 0 U2 2 PU AMER MOSQUITO CONTROL ASSOC PI MOUNT LAUREL PA 15000 COMMERCE PARKWAY, SUITE C, MOUNT LAUREL, NJ 08054 USA SN 8756-971X J9 J AM MOSQUITO CONTR JI J. Am. Mosq. Control Assoc. PD SEP PY 2012 VL 28 IS 3 BP 248 EP 254 PG 7 WC Entomology SC Entomology GA 013HH UT WOS:000309296000013 PM 23833906 ER PT J AU Martini, WZ Cortez, DS Dubick, MA Blackbourne, LH AF Martini, Wenjun Z. Cortez, Douglas S. Dubick, Michael A. Blackbourne, Lorne H. TI Different recovery profiles of coagulation factors, thrombin generation, and coagulation function after hemorrhagic shock in pigs SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY LA English DT Article DE Hemorrhagic shock; fibrinogen; platelets; thromboelastography ID TRAUMA EXSANGUINATION PROTOCOL; PARTIAL THROMBOPLASTIN TIME; DAMAGE CONTROL HEMATOLOGY; BLOOD-PRODUCT UTILIZATION; FIBRINOGEN CONCENTRATE; FACTOR-XIII; INDEPENDENT CONTRIBUTIONS; HYPERCOAGULABLE STATE; MASSIVE TRANSFUSION; PROTHROMBIN TIME AB BACKGROUND: Hemorrhagic shock contributes to coagulopathy after trauma. We investigated daily changes of coagulation components and coagulation function for 5 days in hemorrhaged and resuscitated pigs. METHODS: Fourteen pigs were randomized into the sham control (C) and the hemorrhage and lactated Ringer's resuscitation (H-LR) groups. On day 1, hemorrhage was induced in the H-LR group by bleeding 35% of the total blood volume, followed by LR resuscitation at three times the bled volume. Pigs in the C group were not hemorrhaged or resuscitated. Hemodynamics and coagulation were measured daily after H-LR on day 1 to day 5. RESULTS: No changes in hemodynamics and coagulation function occurred in C. Hemorrhage decreased mean arterial pressure and increased heart rate. LR resuscitation corrected these changes within 2 hours. Compared with the baseline values (BL) on day 1, fibrinogen levels were decreased to 76% +/- 6% by H-LR on day 1, increased to 217% +/- 16% on day 2, and remained increased thereafter; platelet counts were decreased to 63% +/- 5% by H-LR on day 1 and remained lower on days 2 and 3 but returned to BL by days 4 and 5 (all p < 0.05). Thrombin generation was decreased by H-LR on days 1 and 2 but then increased to above BL on days 4 and 5. Coagulation factor levels were decreased by H-LR on day 1 but returned to BL on day 3 except for factor XIII. Clot strength was decreased by H-LR on day 1 and returned to BL by day 2. Clot rapidity did not change on day 1 but was decreased on days 2 and 3 and returned to BL on days 4 and 5. CONCLUSION: Hemorrhage and resuscitation reduced coagulation components and compromised coagulation function, which showed different recovery profiles over the 5-day study period. (J Trauma Acute Care Surg. 2012; 73: 640-647. Copyright (C) 2012 by Lippincott Williams & Wilkins) C1 [Martini, Wenjun Z.; Cortez, Douglas S.; Dubick, Michael A.; Blackbourne, Lorne H.] USA, Inst Surg Res, San Antonio, TX 78234 USA. RP Martini, WZ (reprint author), USA, Inst Surg Res, 3698 Chambers Pass, San Antonio, TX 78234 USA. EM wenjun.martini@amedd.army.mil FU Veterinary Support Division; Laboratory Support Division at the US Army Institute of Surgical Research FX We appreciate the support received from the Veterinary Support Division and the Laboratory Support Division at the US Army Institute of Surgical Research in animal studies and coagulation measurements. We thank Dr. James Aden and Mr. John Jones for their assistance with statistical analysis and Ms. Otilia Sanchez for editing the manuscript. NR 30 TC 4 Z9 4 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 2163-0755 J9 J TRAUMA ACUTE CARE JI J. Trauma Acute Care Surg. PD SEP PY 2012 VL 73 IS 3 BP 640 EP 647 DI 10.1097/TA.0b013e318253b693 PG 8 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 009TK UT WOS:000309047900016 PM 22710770 ER PT J AU Dai, TH Murray, CK Vrahas, MS Baer, DG Tegos, GP Hamblin, MR AF Dai, Tianhong Murray, Clinton K. Vrahas, Mark S. Baer, David G. Tegos, George P. Hamblin, Michael R. TI Ultraviolet C light for Acinetobacter baumannii wound infections in mice: Potential use for battlefield wound decontamination? SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY LA English DT Article DE Skin abrasion; burn; Acinetobacter baumannii; ultraviolet C; combat-related infection ID MULTIDRUG-RESISTANT ACINETOBACTER; INTERSTITIAL PHOTODYNAMIC THERAPY; EXTREMITY INJURIES; BURN INFECTIONS; INACTIVATION; PREVENTION; BACTERIA; MANAGEMENT; OPERATIONS; RADIATION AB BACKGROUND: Since the beginning of the conflicts in the Middle East, US Army physicians have noted a high rate of multidrug-resistant Acinetobacter baumannii infections among US soldiers wounded and initially treated in Iraq. In this study, we investigated the use of ultraviolet C (UVC) light for prevention of multidrug-resistant A. baumannii wound infections using mouse models. METHODS: Partial-thickness skin abrasions and full-thickness burns in mice were infected with a multidrug-resistant A. baumannii isolate recovered from a wounded US soldier deployed to Iraq. The luxCDABE operon, which was contained in plasmid pMF 385, was cloned into the A. baumannii strain. This allowed real-time monitoring of the extent of infection in mice using bioluminescence imaging. UVC light was delivered to the mouse wounds at 30 minutes after the inoculation of A. baumannii. Groups of infected mouse wounds without being exposed to UVC served as the controls. RESULTS: In vitro studies demonstrated that A. baumannii cells were inactivated at UVC exposures much lower than those needed for a similar effect on mammalian cells. It was observed in animal studies that UVC (3.24 J/cm(2) for abrasions and 2.59 J/cm(2) for burns) significantly reduced the bacterial burdens in UVC-treated wounds by approximately 10-fold compared with nontreated controls (p = 0.004 for abrasions, p = 0.019 for burns). DNA lesions were observed by immunofluorescence in mouse skin abrasions immediately after a UVC exposure of 3.24 J/cm(2); however, the lesions were extensively repaired within 72 hours. CONCLUSION: These results suggested that UVC may be useful in preventing combat-related wound infections. (J Trauma Acute Care Surg. 2012; 73: 661-667. Copyright (C) 2012 by Lippincott Williams & Wilkins) C1 [Dai, Tianhong; Tegos, George P.; Hamblin, Michael R.] Massachusetts Gen Hosp, Wellman Ctr Photomed, Boston, MA 02114 USA. [Dai, Tianhong; Tegos, George P.; Hamblin, Michael R.] Harvard Univ, Sch Med, Dept Dermatol, Boston, MA 02115 USA. [Murray, Clinton K.] Brooke Army Med Ctr, Infect Dis Serv, Ft Sam Houston, TX 78234 USA. [Vrahas, Mark S.] Massachusetts Gen Hosp, Dept Orthopaed Surg, Boston, MA 02114 USA. [Baer, David G.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Tegos, George P.] Univ New Mexico, Sch Med, Dept Pathol, Albuquerque, NM 87131 USA. [Hamblin, Michael R.] MIT, Harvard Mit Div Hlth Sci & Technol, Cambridge, MA 02139 USA. RP Hamblin, MR (reprint author), Massachusetts Gen Hosp, Wellman Ctr Photomed, 40 Blossom St,BAR 414, Boston, MA 02114 USA. EM hamblin@helix.mgh.harvard.edu OI Hamblin, Michael/0000-0001-6431-4605 FU Airlift Research Foundation Extremity Trauma Research Grant [109421]; COTA/Smith Nephew Grant [2012-16]; National Institutes of Health [RO1AI050875, 5U54MH084690-02] FX The authors declare no conflicts of interest. This study was supported in part by an Airlift Research Foundation Extremity Trauma Research Grant (grant 109421 to T. D.), a COTA/Smith & Nephew Grant (Grant 2012-16 to T. D.), and the National Institutes of Health (grant RO1AI050875 to M. R. H.). G. P. T. was supported by the National Institutes of Health (grant 5U54MH084690-02). NR 29 TC 7 Z9 7 U1 0 U2 7 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 2163-0755 J9 J TRAUMA ACUTE CARE JI J. Trauma Acute Care Surg. PD SEP PY 2012 VL 73 IS 3 BP 661 EP 667 DI 10.1097/TA.0b013e31825c149c PG 7 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 009TK UT WOS:000309047900019 PM 22929495 ER PT J AU Reddy, KM Guo, JJ Shinoda, Y Fujita, T Hirata, A Singh, JP McCauley, JW Chen, MW AF Reddy, K. Madhav Guo, J. J. Shinoda, Y. Fujita, T. Hirata, A. Singh, J. P. McCauley, J. W. Chen, M. W. TI Enhanced mechanical properties of nanocrystalline boron carbide by nanoporosity and interface phases SO NATURE COMMUNICATIONS LA English DT Article ID ELASTIC-MODULUS; CERAMICS; INDENTATION; COMPOSITES; DEFORMATION; TOUGHNESS; STRENGTH; BEHAVIOR; POROSITY; FRACTURE AB Ceramics typically have very high hardness, but low toughness and plasticity. Besides intrinsic brittleness associated with rigid covalent or ionic bonds, porosity and interface phases are the foremost characteristics that lead to their failure at low stress levels in a brittle manner. Here we show that, in contrast to the conventional wisdom that these features are adverse factors in mechanical properties of ceramics, the compression strength, plasticity and toughness of nanocrystalline boron carbide can be noticeably improved by introducing nanoporosity and weak amorphous carbon at grain boundaries. Transmission electron microscopy reveals that the unusual nanosize effect arises from the deformation-induced elimination of nanoporosity mediated by grain boundary sliding with the assistance of the soft grain boundary phases. This study has important implications in developing high-performance ceramics with ultrahigh strength and enhanced plasticity and toughness. C1 [Reddy, K. Madhav; Guo, J. J.; Fujita, T.; Hirata, A.; Chen, M. W.] Tohoku Univ, WPI Adv Inst Mat Res, Sendai, Miyagi 9808577, Japan. [Shinoda, Y.] Tokyo Inst Technol, Mat & Struct Lab, Yokohama, Kanagawa 2268503, Japan. [Singh, J. P.; McCauley, J. W.] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. [Chen, M. W.] Shanghai Jiao Tong Univ, Sch Mat Sci & Engn, State Key Lab Met Matrix Composites, Shanghai 200030, Peoples R China. [Chen, M. W.] JST, CREST, Kawaguchi, Saitama 3320012, Japan. RP Chen, MW (reprint author), Tohoku Univ, WPI Adv Inst Mat Res, Sendai, Miyagi 9808577, Japan. EM mwchen@wpi-aimr.tohoku.ac.jp RI Fujita, Takeshi/B-1867-2009; Hirata, Akihiko/A-4850-2010; Chen, Mingwei/A-4855-2010; Shinoda, Yutaka/F-7502-2014; guo, junjie/I-3189-2012 OI Fujita, Takeshi/0000-0002-2318-0433; Chen, Mingwei/0000-0002-2850-8872; guo, junjie/0000-0002-3414-3734 FU JST-CREST 'Phase Interface Science for Highly Efficient Energy Utilization', JST, Japan; Global COE Programme 'Materials Integration (International Centre of Education and Research), Tohoku University', MEXT, Japan; JST-PRESTO 'New Materials Science and Element Strategy', JST, Japan FX This work was sponsored by JST-CREST 'Phase Interface Science for Highly Efficient Energy Utilization', JST, Japan. K.M.R. and J.J.G. were supported by the graduate scholarships of Global COE Programme 'Materials Integration (International Centre of Education and Research), Tohoku University', MEXT, Japan. T.F. was supported by JST-PRESTO 'New Materials Science and Element Strategy', JST, Japan. NR 34 TC 25 Z9 25 U1 5 U2 79 PU NATURE PUBLISHING GROUP PI LONDON PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND SN 2041-1723 J9 NAT COMMUN JI Nat. Commun. PD SEP PY 2012 VL 3 AR 1052 DI 10.1038/ncomms2047 PG 7 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 013XA UT WOS:000309338100019 PM 22968698 ER PT J AU Nielsen, PE Munroe, M Foglia, L Piecek, RI Backman, MP Cypher, R Smith, DC AF Nielsen, Peter E. Munroe, Michelle Foglia, Lisa Piecek, Roxanne I. Backman, Mary Paul Cypher, Rebecca Smith, Denise C. TI Collaborative Practice Model Madigan Army Medical Center SO OBSTETRICS AND GYNECOLOGY CLINICS OF NORTH AMERICA LA English DT Article DE Collaboration between midwives and obstetricians; Graduate medical education; Delivery of healthcare; Military medicine ID MIDWIFERY; MIDWIVES; OUTCOMES; CARE AB In 2007, Madigan Army Medical Center implemented a new maternity care delivery model, integrating obstetricians and certified nurse-midwives (CNMs) in a collaborative practice. The change was driven by multiple factors, including patient preference, changes in the resident workweek, and low provider satisfaction. This article describes the elements of successful collaboration, including the structure, effective teamwork principles, role of the CNM in resident education, and preliminary data on mode of delivery, the number of CNM-supervised resident births, and procedures, such as episiotomy and epidural use. C1 [Smith, Denise C.] Univ Colorado, Coll Nursing, Aurora, CO 80045 USA. [Nielsen, Peter E.] Western Reg Med Command, Joint Base Lewis Mcchord, WA 98433 USA. [Munroe, Michelle] Kenner Army Hlth Clin, Ft Lee, VA 23801 USA. [Foglia, Lisa] Madigan Army Med Ctr, OB GYN Residency Program, Tacoma, WA 98431 USA. [Piecek, Roxanne I.] Madigan Army Med Ctr, Nurse Midwifery Serv, Tacoma, WA 98431 USA. RP Smith, DC (reprint author), Univ Colorado, Coll Nursing, Mail Stop C28813120,E 19th Ave, Aurora, CO 80045 USA. EM denise.smith@ucdenver.edu NR 19 TC 6 Z9 6 U1 1 U2 8 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0889-8545 EI 1558-0474 J9 OBSTET GYN CLIN N AM JI Obstet. Gynecol. Clin. N. Am. PD SEP PY 2012 VL 39 IS 3 BP 399 EP + DI 10.1016/j.ogc.2012.05.008 PG 13 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA 016DW UT WOS:000309498700010 PM 22963699 ER PT J AU Vacchi, D AF Vacchi, David TI Veterans in Higher Education: When Johnny and Jane Come Marching to Campus SO REVIEW OF HIGHER EDUCATION LA English DT Book Review C1 [Vacchi, David] USA, Washington, DC 20310 USA. [Vacchi, David] Univ Massachusetts Amherst, Sch Educ, Amherst, MA USA. RP Vacchi, D (reprint author), USA, Washington, DC 20310 USA. NR 5 TC 0 Z9 0 U1 1 U2 5 PU JOHNS HOPKINS UNIV PRESS PI BALTIMORE PA JOURNALS PUBLISHING DIVISION, 2715 NORTH CHARLES ST, BALTIMORE, MD 21218-4363 USA SN 0162-5748 J9 REV HIGH EDUC JI Rev. High. Educ. PD FAL PY 2012 VL 36 IS 1 BP 138 EP 139 PG 2 WC Education & Educational Research SC Education & Educational Research GA 015JP UT WOS:000309442500013 ER PT J AU Bromberg, L Klichko, Y Chang, EP Speakman, S Straut, CM Wilusz, E Hatton, TA AF Bromberg, Lev Klichko, Yaroslav Chang, Emily P. Speakman, Scott Straut, Christine M. Wilusz, Eugene Hatton, T. Alan TI Alkylaminopyridine-Modified Aluminum Aminoterephthalate Metal-Organic Frameworks As Components of Reactive Self-Detoxifying Materials SO ACS APPLIED MATERIALS & INTERFACES LA English DT Article DE metal organic framework; aluminum aminoterephthalate; self-detoxifying materials; alkylaminopyridine; organophosphates ID CHEMICAL WARFARE AGENTS; AEROBIC DECONTAMINATION; TEREPHTHALATE MIL-53; CATALYTIC-PROPERTIES; SEPARATION; POLYMERS; NANOPARTICLES; PROTECTION; OXIDATION; ANALOGS AB Aluminum aminoterephthalate MOF particulate materials (NH2-MIL-101(Al) and NH2-MIL-53(Al)), studied here as components of self-detoxifying surfaces, retained their reactivity following their covalent attachment to protective surfaces utilizing a newly developed strategy in which the MOF particles were deposited on a reactive adhesive composed of polyisobutylene/toluene diisocyanate (PIB/TDI) blends. Following MOF attachment and curing, the MOF primary amino groups were functionalized with highly nucleophilic 4-methylaminopyridine (4-MAP) by disuccinimidyl suberate-activated conjugation. The resulting MOF-4-MAP modified PIB/TDI elastomeric films were mechanically flexible and capable of degrading diisopropyl fluorophosphate (DFP), a chemical threat simulant. C1 [Bromberg, Lev; Klichko, Yaroslav; Chang, Emily P.; Hatton, T. Alan] MIT, Dept Chem Engn, Cambridge, MA 02139 USA. [Speakman, Scott] MIT, Dept Mat Sci & Engn, Cambridge, MA 02139 USA. [Straut, Christine M.] Battelle Natick Operat, Natick, MA 01760 USA. [Wilusz, Eugene] US Army Natick Soldier Res, Ctr Dev & Engn, Mat & Def Sci Div, Natick, MA 01760 USA. RP Hatton, TA (reprint author), MIT, Dept Chem Engn, 77 Massachusetts Ave, Cambridge, MA 02139 USA. EM tahatton@mit.edu FU Defense Threat Reduction Agency; U.S. Army Research Office; [HDTRA1-09-1-0012] FX The authors were supported by the Defense Threat Reduction Agency, in part by Grant HDTRA1-09-1-0012, and by the U.S. Army Research Office. NR 42 TC 10 Z9 10 U1 15 U2 123 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1944-8244 J9 ACS APPL MATER INTER JI ACS Appl. Mater. Interfaces PD SEP PY 2012 VL 4 IS 9 BP 4595 EP 4602 DI 10.1021/am3009696 PG 8 WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary SC Science & Technology - Other Topics; Materials Science GA 010MZ UT WOS:000309099800024 PM 22871803 ER PT J AU Ihnen, AC Petrock, AM Chou, T Fuchs, BE Lee, WY AF Ihnen, Andrew C. Petrock, Anne M. Chou, Tsengming Fuchs, Brian E. Lee, Woo Y. TI Organic Nanocomposite Structure Tailored by Controlling Droplet Coalescence during Inkjet Printing SO ACS APPLIED MATERIALS & INTERFACES LA English DT Article DE inkjet printing; organic nanocomposite materials; droplet spacing; ink droplet coalescence; supersaturation; crystal nucleation and growth ID SESSILE DROPLET; MORPHOLOGY; MICROSTRUCTURE; EVAPORATION; PATTERNS AB Inkjet printing offers a low-cost, high-throughput avenue for producing functional organic materials through rapid translation of desktop discoveries to industrial roll-to-roll processes. Here, we report a simple, but effective strategy to control droplet coalescence during inkjet printing, as a major variable, to tailor the nanoscale morphology of organic composite materials produced upon evaporation of all-liquid inks. During deposition, the spacing between ink droplets was controlled to systematically vary the extent of droplet coalescence. Our results show that decreasing coalescence increased the solvent evaporation rate, supersaturation of the solutes, and nucleation density of the precipitating organic crystals. This phenomenon was utilized to tailor the average size of pentaerythritol tetranitrate (PETN) crystals dispersed in an adhesive binder matrix from similar to 0.2 to upwards of 100 mu m. The results suggest that controlling the extent of droplet coalescence can be used as an effective means to tailor the composite morphology of printed organic materials at the nanoscale. C1 [Ihnen, Andrew C.; Chou, Tsengming; Lee, Woo Y.] Stevens Inst Technol, Dept Chem Engn & Mat Sci, Hoboken, NJ 07030 USA. [Petrock, Anne M.; Fuchs, Brian E.] USA, Armament Res Dev & Engn Ctr, Picatinny Arsenal, NJ 07806 USA. RP Lee, WY (reprint author), Stevens Inst Technol, Dept Chem Engn & Mat Sci, Hoboken, NJ 07030 USA. EM wlee@stevens.edu FU U.S. Army [W15QKN-05-D-0011]; National Science Foundation [DMR-0922522] FX We thank Professor Chang-Hwan Choi and Mr. Wei Xu of Stevens for their thoughtful discussions about droplet evaporation. We also thank Dr. Daniel Stec III of SAIC and Mr. Rodger E. Cornell of U.S. Army-ARDEC for laboratory support. This research was sponsored by the U.S. Army under contract W15QKN-05-D-0011 and used SEM-FIB microscope resources partially funded by the National Science Foundation through NSF Grant DMR-0922522. NR 40 TC 7 Z9 7 U1 6 U2 41 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1944-8244 J9 ACS APPL MATER INTER JI ACS Appl. Mater. Interfaces PD SEP PY 2012 VL 4 IS 9 BP 4691 EP 4699 DI 10.1021/am301050n PG 9 WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary SC Science & Technology - Other Topics; Materials Science GA 010MZ UT WOS:000309099800037 PM 22950443 ER PT J AU Vasterling, JJ Brailey, K Proctor, SP Kane, R Heeren, T Franz, M AF Vasterling, Jennifer J. Brailey, Kevin Proctor, Susan P. Kane, Robert Heeren, Timothy Franz, Molly TI Neuropsychological outcomes of mild traumatic brain injury, post-traumatic stress disorder and depression in Iraq-deployed US Army soldiers SO BRITISH JOURNAL OF PSYCHIATRY LA English DT Article ID UK MILITARY PERSONNEL; PERSIAN-GULF-WAR; SYMPTOMS; VETERANS; HEALTH; COHORT; AFGHANISTAN; SEQUELAE; TBI; INFORMATION AB Background Traumatic brain injury (TBI) is a concern of contemporary military deployments. Whether milder TBI leads to enduring impairment remains controversial. Aims To determine the influence of deployment TBI, and post-traumatic stress disorder (PTSD) and depression symptoms on neuropsychological and functional outcomes. Method A sample of 760 US Army soldiers were assessed pre- and post-deployment. Outcomes included neuropsychological performances and subjective functional impairment. Results In total, 9% of the participants reported (predominantly mild) TBI with loss of consciousness between pre- and post-deployment. At post-deployment, 17.6% of individuals with TBI screened positive for PTSD and 31.3% screened positive for depression. Before and after adjustment for psychiatric symptoms, TBI was significantly associated only with functional impairment. Both PTSD and depression symptoms adjusted for TBI were significantly associated with several neuropsychological performance deficits and functional impairment. Conclusions Milder TBI reported by deployed service members typically has limited lasting neuropsychological consequences; PTSD and depression are associated with more enduring cognitive compromise. C1 [Vasterling, Jennifer J.; Proctor, Susan P.] USA, VA Boston Healthcare Syst, Environm Med Res Inst, Mil Performance Div,Res Serv, Boston, MA 02130 USA. [Vasterling, Jennifer J.; Brailey, Kevin] Boston Univ, Sch Med, Boston, MA 02118 USA. [Proctor, Susan P.] Boston Univ, Sch Publ Hlth, Dept Environm Hlth, Boston, MA USA. [Kane, Robert] Def & Vet Brain Injury Ctr, Washington, DC USA. [Heeren, Timothy] Boston Univ, Sch Publ Hlth, Dept Biostat, Boston, MA USA. RP Vasterling, JJ (reprint author), USA, VA Boston Healthcare Syst, Environm Med Res Inst, Mil Performance Div,Res Serv, 150 S Huntington Ave, Boston, MA 02130 USA. EM jennifer.vasterling@va.gov OI Heeren, Timothy/0000-0001-5643-3559 FU US Department of Defense CDMRP [W81XWH-08-2-0035]; US Army Medical Research and Materiel Command [DAMD 17-03-0020]; US Veterans Affairs Clinical Sciences Research and Development FX Funding was provided by the US Department of Defense CDMRP (W81XWH-08-2-0035), US Army Medical Research and Materiel Command (DAMD 17-03-0020); and US Veterans Affairs Clinical Sciences Research and Development. The primary funding organisation had no role in the scientific aspects of the study or the preparation of the manuscript. The manuscript underwent scientific and administrative review within the US Army Research Institute for Environmental Medicine and US Army Medical Research and Materiel Command. The content of this article does not necessarily reflect the position or policy of the US government, and no official endorsement should be inferred. NR 36 TC 54 Z9 54 U1 5 U2 22 PU ROYAL COLLEGE OF PSYCHIATRISTS PI LONDON PA BRITISH JOURNAL OF PSYCHIATRY 17 BELGRAVE SQUARE, LONDON SW1X 8PG, ENGLAND SN 0007-1250 J9 BRIT J PSYCHIAT JI Br. J. Psychiatry PD SEP PY 2012 VL 201 IS 3 BP 186 EP 192 DI 10.1192/bjp.bp.111.096461 PG 7 WC Psychiatry SC Psychiatry GA 007OR UT WOS:000308898500006 PM 22743844 ER PT J AU Del Favero, G Florio, C Codan, B Sosa, S Poli, M Sbaizero, O Molgo, J Tubaro, A Lorenzon, P AF Del Favero, Giorgia Florio, Chiara Codan, Barbara Sosa, Silvio Poli, Mark Sbaizero, Orfeo Molgo, Jordi Tubaro, Aurelia Lorenzon, Paola TI The Stretch-Activated Channel Blocker Gd3+ Reduces Palytoxin Toxicity in Primary Cultures of Skeletal Muscle Cells SO CHEMICAL RESEARCH IN TOXICOLOGY LA English DT Article ID VASCULAR SMOOTH-MUSCLE; CONTRACTILE ACTION; ION CHANNELS; MECHANISMS; MYOBLASTS; RELEASE; FROG; NA+,K+-ATPASE; EXPOSURE; BINDING AB Palytoxin (PLTX) is one of the most toxic seafood contaminants ever isolated. Reports of human food-borne poisoning ascribed to PLTX suggest skeletal muscle as a primary target site. Primary cultures of mouse skeletal muscle cells were used to study the relationship between Ca2+ response triggered by PLTX and the development of myotoxic insult. Ca2+ imaging experiments revealed that PLTX causes a transitory intracellular Ca2+ response (transient phase) followed by a slower and more sustained Ca2+ increase (long-lasting phase). The transient phase is due to Ca2+ release from intracellular stores and entry through voltage-dependent channels and the Na+/Ca2+ exchanger (reverse mode). The long-lasting phase is due to a massive and prolonged Ca2+ influx from the extracellular compartment. Sulforhodamine B assay revealed that the long-lasting phase is the one responsible for the toxicity in skeletal muscle cells. Our data analyzed, for the first time, pathways of PLTX-induced Ca2+ entry and their correlation with PLTX-induced toxicity in skeletal muscle cells. The cellular morphology changes induced by PLTX and the sensitivity to gadolinium suggest a role for stretch-activated channels. C1 [Del Favero, Giorgia; Florio, Chiara; Sosa, Silvio; Tubaro, Aurelia; Lorenzon, Paola] Univ Trieste, Dept Life Sci, I-34127 Trieste, Italy. [Codan, Barbara; Sbaizero, Orfeo] Univ Trieste, Dept Ind Engn & Informat Technol, I-34127 Trieste, Italy. [Poli, Mark] USA, Med Res Inst Infect Dis, Ft Detrick, MD 21701 USA. [Molgo, Jordi] CNRS, Inst Federatif Neurobiol Alfred Fessard, Lab Neurobiol & Dev, UPR 3294, F-91198 Gif Sur Yvette, France. RP Tubaro, A (reprint author), Univ Trieste, Dept Life Sci, I-34127 Trieste, Italy. EM tubaro@units.it FU Italian Ministry of Education, University and Research (PRIN) FX This work was supported by the Italian Ministry of Education, University and Research (PRIN). NR 49 TC 7 Z9 7 U1 0 U2 9 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0893-228X J9 CHEM RES TOXICOL JI Chem. Res. Toxicol. PD SEP PY 2012 VL 25 IS 9 BP 1912 EP 1920 DI 10.1021/tx300203x PG 9 WC Chemistry, Medicinal; Chemistry, Multidisciplinary; Toxicology SC Pharmacology & Pharmacy; Chemistry; Toxicology GA 005VB UT WOS:000308777100013 PM 22900474 ER PT J AU Kuzhuget, AV Beilina, L Klibanov, MV Sullivan, A Nguyen, L Fiddy, MA AF Kuzhuget, Andrey V. Beilina, Larisa Klibanov, Michael V. Sullivan, Anders Lam Nguyen Fiddy, Michael A. TI Blind backscattering experimental data collected in the field and an approximately globally convergent inverse algorithm SO INVERSE PROBLEMS LA English DT Article ID SCATTERING PROBLEM; NOVIKOV ALGORITHM; NUMERICAL-METHOD; FIXED-ENERGY; 3 DIMENSIONS; RECONSTRUCTION; TOMOGRAPHY AB An approximately globally convergent numerical method for a 1D coefficient inverse problem for a hyperbolic PDE is applied to image dielectric constants of targets from blind experimental data. The data were collected in the field by the Forward Looking Radar of the US Army Research Laboratory. A posteriori analysis has revealed that computed and tabulated values of dielectric constants are in good agreement. Convergence analysis is presented. C1 [Klibanov, Michael V.] Univ N Carolina, Dept Math & Stat, UNCC ChalmersGU Team, Charlotte, NC 28223 USA. [Kuzhuget, Andrey V.] Morgan Stanley & Co Inc, UNCC ChalmersGU Team, New York, NY 10036 USA. [Beilina, Larisa] Chalmers, Dept Math Sci, UNCC ChalmersGU Team, SE-42196 Gothenburg, Sweden. [Beilina, Larisa] Gothenburg Univ, UNCC ChalmersGU Team, SE-42196 Gothenburg, Sweden. [Sullivan, Anders; Lam Nguyen] USA, Res Lab, ARL Team, Adelphy, MD 20783 USA. [Fiddy, Michael A.] Univ N Carolina, Optoelect Ctr, UNCC ChalmersGU Team, Charlotte, NC 28223 USA. RP Klibanov, MV (reprint author), Univ N Carolina, Dept Math & Stat, UNCC ChalmersGU Team, Charlotte, NC 28223 USA. EM larisa@chalmers.se; mklibanv@uncc.edu; anders.j.sullivan.civ@mail.mil; lam.h.nguyen2.civ@mail.mil; mafiddy@uncc.edu FU US Army Research Laboratory; US Army Research Office [W911NF-11-1-0399]; Swedish Research Council; Swedish Foundation for Strategic Research (SSF) in Gothenburg Mathematical Modelling Centre (GMMC); Swedish Institute FX This research was supported by the US Army Research Laboratory and US Army Research Office grant W911NF-11-1-0399, the Swedish Research Council, the Swedish Foundation for Strategic Research (SSF) in Gothenburg Mathematical Modelling Centre (GMMC) and by the Swedish Institute, Visby Program. The authors are grateful to Drs Paul Sacks and Natee Pantong for a number of useful discussions. NR 45 TC 21 Z9 21 U1 0 U2 3 PU IOP PUBLISHING LTD PI BRISTOL PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND SN 0266-5611 J9 INVERSE PROBL JI Inverse Probl. PD SEP PY 2012 VL 28 IS 9 AR 095007 DI 10.1088/0266-5611/28/9/095007 PG 33 WC Mathematics, Applied; Physics, Mathematical SC Mathematics; Physics GA 006DO UT WOS:000308799900008 ER PT J AU Wozniak, JR Swannack, TM Butzler, R Llewellyn, C Davis, SE AF Wozniak, Jeffrey R. Swannack, Todd M. Butzler, Rachel Llewellyn, Christopher Davis, Stephen E., III TI River inflow, estuarine salinity, and Carolina wolfberry fruit abundance: linking abiotic drivers to Whooping Crane food SO JOURNAL OF COASTAL CONSERVATION LA English DT Article DE Freshwater inflow; Fruit abundance; Marsh salinity; Inundation level; Mesocosm; Aransas National Wildlife Refuge (ANWR); Whooping Crane ID HYPERSALINE SALT-MARSH; EMERGENT VEGETATION; IRIS-HEXAGONA; CLONAL PLANT; LEAF-AREA; GROWTH; STRESS; USA; REPRODUCTION; VARIABILITY AB The supply of freshwater to estuarine ecosystems is a critical factor in maintaining the overall health and organization of coastal marshes. Specifically along the Texas Gulf coast, the coupled effects of decreased freshwater inflows to the estuary and natural processes (e.g., precipitation, wind, and tides) can exert significant salt-stress on coastal marsh vegetation. In this project we sought to quantitatively link the inflow of freshwater to the estuary (San Antonio Bay) with Aransas National Wildlife Refuge (ANWR) coastal marsh salinity and assess the influence of salinity and inundation on Carolina wolfberry (Lycium carolinianum Walt.) phenology (leaf and fruit abundance). The Carolina wolfberry is one of the more common high marsh plant species found at ANWR and has been shown to be a key food source for endangered Whooping Cranes which inhabit the coastal marshes of the ANWR each fall/winter. Results from our study show that periods of decreased freshwater inflows to the estuary correlated with increased marsh salinity at the ANWR. Wolfberry plants at ANWR marsh sites displayed increased fruit abundance during years which had lower mean summer time salinity (June, July, and August) in San Antonio Bay; conversely, during years of increased bay salinity during the same summertime months, wolfberry plants showed decreased fruit abundance. Through the continued validation of the relationship between inflows and coastal marsh salinity, we hope to provide additional insight into how wolfberry phenology varies inter-annually across both salinity and inundation regimes and how freshwater inflows may affect food availability for the endangered Whooping Crane. C1 [Wozniak, Jeffrey R.] Sam Houston State Univ, Texas Res Inst Environm Studies, Huntsville, TX 77340 USA. [Swannack, Todd M.] USA, Environm Lab, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. [Butzler, Rachel] City Knoxville, Stormwater Management, Dept Engn, Knoxville, TN 37902 USA. [Llewellyn, Christopher] Texas A&M Univ, Dept Wildlife & Fisheries Sci, College Stn, TX 77843 USA. [Davis, Stephen E., III] Everglades Fdn, Palmetto Bay, FL 33157 USA. RP Wozniak, JR (reprint author), Sam Houston State Univ, Texas Res Inst Environm Studies, Huntsville, TX 77340 USA. EM wozniak@shsu.edu FU Guadalupe-Blanco River Authority; San Antonio River Authority; San Antonio Guadalupe Estuarine System (SAGES) project; San Antonio Water System; Texas Water Development Board; REU Fellowship [EEC-9912278] FX We thank the Guadalupe-Blanco River Authority and the San Antonio River Authority for direct funding and sponsorship of the San Antonio Guadalupe Estuarine System (SAGES) project. We also thank the San Antonio Water System and the Texas Water Development Board for contributing funding. CL's work was supported in part by an REU Fellowship (NSF grant EEC-9912278). In addition, we thank Tyson Hart, Melissa Romigh, Matthew Driffill, Kung-Jen Liu, Tom Stehn and the U. S. Fish and Wildlife Service at the Aransas National Wildlife Refuge for their generous on-site support. NR 44 TC 2 Z9 2 U1 3 U2 40 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1400-0350 J9 J COAST CONSERV JI J. Coast. Conserv. PD SEP PY 2012 VL 16 IS 3 BP 345 EP 354 DI 10.1007/s11852-012-0205-4 PG 10 WC Biodiversity Conservation; Environmental Sciences; Marine & Freshwater Biology; Water Resources SC Biodiversity & Conservation; Environmental Sciences & Ecology; Marine & Freshwater Biology; Water Resources GA 988SL UT WOS:000307510900009 ER PT J AU Gaydos, S AF Gaydos, Steven TI CLINICAL AUSCULTATION IN NOISY ENVIRONMENTS SO JOURNAL OF EMERGENCY MEDICINE LA English DT Letter C1 USA, Aeromed Res Lab, Warfighter Performance & Hlth Div, Ft Rucker, AL USA. RP Gaydos, S (reprint author), USA, Aeromed Res Lab, Warfighter Performance & Hlth Div, Ft Rucker, AL USA. NR 7 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0736-4679 J9 J EMERG MED JI J. Emerg. Med. PD SEP PY 2012 VL 43 IS 3 BP 492 EP 493 DI 10.1016/j.jemermed.2011.07.039 PG 2 WC Emergency Medicine SC Emergency Medicine GA 011GR UT WOS:000309153600023 PM 22406026 ER PT J AU Brown, SL Clausen, I Chappell, MA Scheckel, KG Newville, M Hettiarachchi, GM AF Brown, Sally L. Clausen, Ingrid Chappell, Mark A. Scheckel, Kirk G. Newville, Matthew Hettiarachchi, Ganga M. TI High-Iron Biosolids Compost-Induced Changes in Lead and Arsenic Speciation and Bioaccessibility in Co-contaminated Soils SO JOURNAL OF ENVIRONMENTAL QUALITY LA English DT Article ID SIMULATED GASTROINTESTINAL SYSTEM; BLOOD LEAD; IN-SITU; AMENDED SOILS; FERROUS IRON; NEW-ORLEANS; URBAN; FERRIHYDRITE; BIOAVAILABILITY; OXIDE AB The safety of urban farming has been questioned due to the potential for contamination in urban soils. A laboratory incubation, a field trial, and a second laboratory incubation were conducted to test the ability of high-Fe biosolids-based composts to reduce the bioaccessibility of soil Pb and As in situ. Lead and As bioaccessibility were evaluated using an in vitro assay. Changes in Pb, As, and Fe speciation were determined on select samples aft er the second laboratory incubation using mu-X-ray fluorescence mapping followed by mu-X-ray absorption near-edge structure (XANES). A compost with Fe added to wastewater treatment residuals (Fe WTR compost) added to soils at 100 g kg(-1) decreased Pb bioaccessibility in both laboratory incubations. Mixed results were observed for As. Composts tested in the field trial (Fe added as Fe powder or FeCl2) did not reduce bioaccessible Pb, and limited reductions were observed in bioaccessible As. These composts had no effect on Pb bioaccessibility during the second laboratory incubation. Bulk XANES showed association of Pb with sulfates and carbonates in the control soil. mu-XANES for three points in the Fe WTR amended soil showed Pb present as Fe-sorbed Pb (88 and 100% of two points) and pyromorphite (12 and 53% of two points). Bulk XANES of the Fe WTR compost showed 97% of total Fe present as Fe3+. The results of this study indicate that addition of high-Fe biosolids compost is an effective means to reduce Pb accessibility only for certain types of Fe-rich materials. C1 [Brown, Sally L.; Clausen, Ingrid] Univ Washington, Coll Environm, Seattle, WA 98195 USA. [Chappell, Mark A.] USA, Erdc, Environm Lab, Vicksburg, MS USA. [Scheckel, Kirk G.] US EPA, Natl Risk Management Res Lab, Cincinnati, OH 45224 USA. [Newville, Matthew] Univ Chicago, GSECARS, Chicago, IL 60637 USA. [Hettiarachchi, Ganga M.] Kansas State Univ, Dep Agron, Manhattan, KS 66506 USA. RP Brown, SL (reprint author), Univ Washington, Coll Environm, Seattle, WA 98195 USA. EM slb@u.washington.edu RI Scheckel, Kirk/C-3082-2009; Hettiarachchi, Ganga/F-6895-2015 OI Scheckel, Kirk/0000-0001-9326-9241; Hettiarachchi, Ganga/0000-0002-6669-2885 NR 55 TC 9 Z9 9 U1 1 U2 64 PU AMER SOC AGRONOMY PI MADISON PA 677 S SEGOE RD, MADISON, WI 53711 USA SN 0047-2425 J9 J ENVIRON QUAL JI J. Environ. Qual. PD SEP PY 2012 VL 41 IS 5 BP 1612 EP 1622 DI 10.2134/jeq2011.0297 PG 11 WC Environmental Sciences SC Environmental Sciences & Ecology GA 008BI UT WOS:000308931700028 PM 23099953 ER PT J AU Blank, RA Pourpoint, TL Meyer, SE Heister, SD Anderson, WE AF Blank, R. A. Pourpoint, T. L. Meyer, S. E. Heister, S. D. Anderson, W. E. TI Experimental and Theoretical Performance of High-Pressure Hydrogen Peroxide Catalyst Beds SO JOURNAL OF PROPULSION AND POWER LA English DT Article ID DECOMPOSITION AB A small silver-screen hydrogen peroxide catalyst bed was developed to study the effect of high operating pressures on the performance of the device. The catalyst bed was designed for a nominal mass flow rate of 90 wt % hydrogen peroxide of 0.32 lbm/s (0.145 k g/s) corresponding to a bed loading of 0.4 lbm/s . in(2) (0.03 kg/s . cm(2)). Twelve separate tests were conducted at chamber pressures ranging from 1000 to 4000 psia (69 to 276 bar), and a companion analysis was developed to assess the results and observed trends. Results indicate that the catalyst bed could be operated with high decomposition efficiencies, low pressure drop, and rapid start transients at bed loadings up to three times the conventionally accepted value of 0.4 lbm/s . in(2) (0.03 k g/s . cm(2)). The thermal and pressure profiles within the catalyst bed were also measured, and the real gas implications of operations at high pressures were also assessed. C1 [Blank, R. A.; Pourpoint, T. L.; Meyer, S. E.; Heister, S. D.; Anderson, W. E.] Purdue Univ, Sch Aeronaut & Astronaut, W Lafayette, IN 47907 USA. RP Blank, RA (reprint author), USA, Weap Dev & Integrat Directorate, Aviat & Missile Res Dev & Engn Ctr, RDMR WDP P, Redstone Arsenal, AL 35898 USA. EM timothee@purdue.edu NR 17 TC 3 Z9 3 U1 1 U2 8 PU AMER INST AERONAUT ASTRONAUT PI RESTON PA 1801 ALEXANDER BELL DRIVE, STE 500, RESTON, VA 22091-4344 USA SN 0748-4658 J9 J PROPUL POWER JI J. Propul. Power PD SEP-OCT PY 2012 VL 28 IS 5 BP 912 EP 917 DI 10.2514/1.B34432 PG 6 WC Engineering, Aerospace SC Engineering GA 007NU UT WOS:000308896200005 ER PT J AU Mehmood, A Sabatier, JM Damarla, T AF Mehmood, Asif Sabatier, James M. Damarla, Thyagaraju TI Ultrasonic Doppler methods to extract signatures of a walking human SO JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA LA English DT Article ID HUMAN GAIT; RADAR AB Extraction of Doppler signatures that characterize human motion has attracted a growing interest in recent years. These Doppler signatures are generated by various components of the human body while walking, and contain unique features that can be used for human detection and recognition. Although, a significant amount of research has been done in radio frequency regime for human Doppler signature extraction, considerably less has been done in acoustics. In this work, 40 kHz ultrasonic sonar is employed to measure the Doppler signature generated by the motion of body segments using different electronic and signal processing schemes. These schemes are based on both analog and digital demodulation with homodyne and heterodyne receiver circuitry. The results and analyses from these different schemes are presented. C1 [Mehmood, Asif; Sabatier, James M.; Damarla, Thyagaraju] USA, Res Lab, Adelphi, MD 20783 USA. RP Mehmood, A (reprint author), USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM asif.kyani@gmail.com; sabatier@olemiss.edu; thyagaraju.damarla.civ@mail.mil NR 11 TC 1 Z9 1 U1 0 U2 11 PU ACOUSTICAL SOC AMER AMER INST PHYSICS PI MELVILLE PA STE 1 NO 1, 2 HUNTINGTON QUADRANGLE, MELVILLE, NY 11747-4502 USA SN 0001-4966 EI 1520-8524 J9 J ACOUST SOC AM JI J. Acoust. Soc. Am. PD SEP PY 2012 VL 132 IS 3 BP EL243 EP EL249 DI 10.1121/1.4746421 PN 1 PG 7 WC Acoustics; Audiology & Speech-Language Pathology SC Acoustics; Audiology & Speech-Language Pathology GA 011HF UT WOS:000309155000012 PM 22979839 ER PT J AU Moinpour, CM Darke, AK Donaldson, GW Cespedes, D Johnson, CR Ganz, PA Patrick, DL Ware, JE Shumaker, SA Meyskens, FL Thompson, IM AF Moinpour, Carol M. Darke, Amy K. Donaldson, Gary W. Cespedes, Duane Johnson, Christine R. Ganz, Patricia A. Patrick, Donald L. Ware, John E., Jr. Shumaker, Sally A. Meyskens, Frank L. Thompson, Ian M., Jr. TI Health-Related Quality-of-Life Findings for the Prostate Cancer Prevention Trial SO JOURNAL OF THE NATIONAL CANCER INSTITUTE LA English DT Article ID URINARY-TRACT SYMPTOMS; SURVEY SF-36; MEN; FINASTERIDE; HYPERPLASIA; RISK; INCREASE; OUTCOMES; TESTS; FAT AB The Prostate Cancer Prevention Trial (PCPT)a randomized placebo-controlled study of the efficacy of finasteride in preventing prostate canceroffered the opportunity to prospectively study effects of finasteride and other covariates on the health-related quality of life of participants in a multiyear trial. We assessed three health-related quality-of-life domains (measured with the Health Survey Short Form36: Physical Functioning, Mental Health, and Vitality scales) via questionnaires completed by PCPT participants at enrollment (3 months before randomization), at 6 months after randomization, and annually for 7 years. Covariate data obtained at enrollment from patient-completed questionnaires were included in our model. Mixed-effects model analyses and a cross-sectional presentation at three time points began at 6 months after randomization. All statistical tests were two-sided. For the physical function outcome (n = 16 077), neither the finasteride main effect nor the finasteride interaction with time were statistically significant. The effects of finasteride on physical function were minor and accounted for less than a 1-point difference over time in Physical Functioning scores (mixed-effect estimate = 0.07, 95% confidence interval [CI] = 0.28 to 0.42, P = .71). Comorbidities such as congestive heart failure (estimate = 5.64, 95% CI = 7.96 to 3.32, P < .001), leg pain (estimate = 2.57, 95% CI = 3.04 to 2.10, P < .001), and diabetes (estimate = 1.31, 95% CI = 2.04 to 0.57, P < .001) had statistically significant negative effects on physical function, as did current smoking (estimate = 2.34, 95% CI = 2.97 to 1.71, P < .001) and time on study (estimate = 1.20, 95% CI = 1.36 to 1.03, P < .001). Finasteride did not have a statistically significant effect on the other two dependent variables, mental health and vitality, either in the mixed-effects analyses or in the cross-sectional analysis at any of the three time points. Finasteride did not negatively affect SF36 Physical Functioning, Mental Health, or Vitality scores. C1 [Moinpour, Carol M.; Patrick, Donald L.] Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Canc Prevent Program, Seattle, WA 98109 USA. [Darke, Amy K.] Fred Hutchinson Canc Res Ctr, SW Oncol Grp, Ctr Stat, Seattle, WA 98109 USA. [Donaldson, Gary W.] Univ Utah, Dept Anesthesiol, Pain Res Ctr, Salt Lake City, UT USA. [Johnson, Christine R.] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. [Cespedes, Duane] Shore Comprehens Urol, Easton, MD USA. [Ganz, Patricia A.] Univ Calif Los Angeles, Sch Med, Los Angeles, CA USA. [Ganz, Patricia A.] Univ Calif Los Angeles, Sch Publ Hlth, Los Angeles, CA 90024 USA. [Ganz, Patricia A.] Univ Calif Los Angeles, Jonsson Comprehens Canc Ctr, Los Angeles, CA 90024 USA. [Moinpour, Carol M.; Patrick, Donald L.] Univ Washington, Dept Hlth Serv, Seattle, WA 98195 USA. [Ware, John E., Jr.] Univ Massachusetts, Sch Med, Dept Quantitat Hlth Sci, Worcester, MA USA. [Shumaker, Sally A.] Wake Forest Sch Med, Div Publ Hlth Sci, Dept Social Sci & Hlth Policy, Winston Salem, NC USA. [Meyskens, Frank L.] Univ Calif Irvine, Chao Family NCI Designated Comprehens Canc Ctr, Irvine, CA USA. [Thompson, Ian M., Jr.] Univ Texas Hlth Sci Ctr San Antonio, Dept Urol, San Antonio, TX 78229 USA. RP Moinpour, CM (reprint author), Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Canc Prevent Program, M3 C102,1100 Fairview Ave N,POB 19024, Seattle, WA 98109 USA. EM cmoinpou@fhcrc.org FU National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD [5 U10 CA37429, 2 U10 CA37429-09]; Merck, Inc; National Cancer Institute (NCI), Division of Cancer Prevention (DCP); DCP/NCI FX This research was supported by Public Health Service grants no. 5 U10 CA37429 and 2 U10 CA37429-09 from the National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD (to IMT, principal investigator).; The study agents (finasteride and placebo) were provided by Merck, Inc. Merck, Inc, and the National Cancer Institute (NCI), Division of Cancer Prevention (DCP), also provided small grants to produce videos and to support projects to enhance trial recruitment and adherence. The study sponsor, DCP/NCI, provided input regarding study design but had no role in the following study activities: collection, analysis, or interpretation of the data; the writing of the manuscript; or the decision to submit the manuscript for publication. The authors extend appreciation to PCPT participants who provided health behaviors information at study entry and faithfully completed the health-related quality-of-life and health behaviors forms over the course of the trial. Study clinical research associates and nurses were also instrumental in our ability to achieve such impressive submission rates for the participant-completed forms. NR 34 TC 5 Z9 5 U1 0 U2 9 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0027-8874 J9 J NATL CANCER I JI J. Natl. Cancer Inst. PD SEP PY 2012 VL 104 IS 18 BP 1373 EP 1385 DI 10.1093/jnci/djs359 PG 13 WC Oncology SC Oncology GA 010ZG UT WOS:000309132500008 PM 22972968 ER PT J AU Stephenson, KE Li, HL Walker, BD Michael, NL Barouch, DH AF Stephenson, Kathryn E. Li, Hualin Walker, Bruce D. Michael, Nelson L. Barouch, Dan H. TI Gag-Specific Cellular Immunity Determines In Vitro Viral Inhibition and In Vivo Virologic Control following Simian Immunodeficiency Virus Challenges of Vaccinated Rhesus Monkeys SO JOURNAL OF VIROLOGY LA English DT Article ID CD8(+) T-CELLS; HIV REPLICATION; EX-VIVO; INFECTION; LYMPHOCYTES; RESPONSES; NEUTRALIZATION; LOAD; SIV; INDIVIDUALS AB A comprehensive vaccine for human immunodeficiency virus type 1 (HIV-1) would block HIV-1 acquisition as well as durably control viral replication in breakthrough infections. Recent studies have demonstrated that Env is required for a vaccine to protect against acquisition of simian immunodeficiency virus (SIV) in vaccinated rhesus monkeys, but the antigen requirements for virologic control remain unclear. Here, we investigate whether CD8(+) T lymphocytes from vaccinated rhesus monkeys mediate viral inhibition in vitro and whether these responses predict virologic control following SIV challenge. We observed that CD8(+) lymphocytes from 23 vaccinated rhesus monkeys inhibited replication of SIV in vitro. Moreover, the magnitude of inhibition prior to challenge was inversely correlated with set point SIV plasma viral loads after challenge. In addition, CD8 cell-mediated viral inhibition in vaccinated rhesus monkeys correlated significantly with Gag-specific, but not Pol- or Env-specific, CD4(+) and CD8(+) T lymphocyte responses. These findings demonstrate that in vitro viral inhibition following vaccination largely reflects Gag-specific cellular immune responses and correlates with in vivo virologic control following infection. These data suggest the importance of including Gag in an HIV-1 vaccine in which virologic control is desired. C1 [Stephenson, Kathryn E.; Li, Hualin; Barouch, Dan H.] Harvard Univ, Beth Israel Deaconess Med Ctr, Sch Med, Div Vaccine Res, Boston, MA 02215 USA. [Walker, Bruce D.; Barouch, Dan H.] Ragon Inst MGH MIT & Harvard, Boston, MA USA. [Walker, Bruce D.] Howard Hughes Med Inst, Chevy Chase, MD USA. [Michael, Nelson L.] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD USA. RP Barouch, DH (reprint author), Harvard Univ, Beth Israel Deaconess Med Ctr, Sch Med, Div Vaccine Res, Boston, MA 02215 USA. EM dbarouch@bidmc.harvard.edu FU U.S. National Institutes of Health [AI07387, AI066305, AI066924, AI078526, AI095985, AI030914]; Bill and Melinda Gates Foundation; Ragon Institute of MGH, MIT, and Harvard FX We acknowledge support from the U.S. National Institutes of Health (AI07387 to K.E.S.; AI066305, AI066924, AI078526, and AI095985 to D.H.B.; AI030914 to B.D.W.), the Bill and Melinda Gates Foundation, and the Ragon Institute of MGH, MIT, and Harvard. NR 29 TC 23 Z9 24 U1 1 U2 2 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0022-538X J9 J VIROL JI J. Virol. PD SEP PY 2012 VL 86 IS 18 BP 9583 EP 9589 DI 10.1128/JVI.00996-12 PG 7 WC Virology SC Virology GA 999TI UT WOS:000308337500003 PM 22761379 ER PT J AU Clayton, JD AF Clayton, J. D. TI On anholonomic deformation, geometry, and differentiation SO MATHEMATICS AND MECHANICS OF SOLIDS LA English DT Article DE anholonomic deformation; curvature; differential geometry; finite strain; multiplicative decomposition; torsion ID CONTINUOUS DISTRIBUTIONS; GRADIENT THEORY; MULTIPLICATIVE ELASTOPLASTICITY; SIMPLE BODIES; DISLOCATIONS; PLASTICITY; CRYSTALS; INCOMPATIBILITY; DISCLINATIONS; DECOMPOSITION AB In geometrically nonlinear theories of inelasticity of solids, the deformation gradient is typically split multiplicatively into two (or more terms), none of which need be integrable to a motion or displacement field. Such terms, when not integrable, are termed anholonomic, and can be associated with intermediate configuration(s) of a deformed material element. In this work, aspects of tensor calculus associated with anholonomic deformation are analyzed in general curvilinear coordinates. Various linear connection coefficients for intermediate configurations are posited or derived; of particular interest are those mapped coefficients corresponding to the choice of identical basis vectors in multiple configurations. It is shown that torsion and curvature associated with such mapped coefficients do not necessarily vanish, even though torsion and curvature tensors of the original connections vanish by definition in reference or current configurations. Intermediate connection coefficients defined in this way exhibit vanishing covariant derivatives of corresponding metric tensors, but are time dependent even when reference (current) configuration connections are fixed in time at a given material (spatial) location. Formulae are derived for total covariant derivatives of two-and three-point tensors with one or more components referred to the intermediate configuration. It is shown that in intermediate coordinates, neither the divergence of the curl of a vector field nor the curl of the gradient of a scalar field need always vanish. The balance of linear momentum for a hyperelastic-plastic material is examined in the context of curvilinear intermediate coordinates. C1 USA, Res Lab, RDRL WMP B, Aberdeen Proving Ground, MD 21005 USA. RP Clayton, JD (reprint author), USA, Res Lab, RDRL WMP B, Aberdeen Proving Ground, MD 21005 USA. EM john.d.clayton1.civ@mail.mil RI Clayton, John/C-7760-2009 NR 46 TC 12 Z9 12 U1 0 U2 4 PU SAGE PUBLICATIONS LTD PI LONDON PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND SN 1081-2865 J9 MATH MECH SOLIDS JI Math. Mech. Solids PD SEP PY 2012 VL 17 IS 7 BP 702 EP 735 DI 10.1177/1081286511429887 PG 34 WC Materials Science, Multidisciplinary; Mathematics, Interdisciplinary Applications; Mechanics SC Materials Science; Mathematics; Mechanics GA 005PK UT WOS:000308762100003 ER PT J AU Athrey, G Lance, RF Leberg, PL AF Athrey, Giri Lance, Richard F. Leberg, Paul L. TI How far is too close? restricted, sex-biased dispersal in black-capped vireos SO MOLECULAR ECOLOGY LA English DT Article DE differentiation; dispersal; endangered birds; fine-scale genetic structure; fragmentation; sex-biased dispersal ID SCALE GENETIC-STRUCTURE; POPULATION-STRUCTURE; SPATIAL AUTOCORRELATION; HABITAT FRAGMENTATION; MOLECULAR MARKERS; BIRD POPULATION; PHILOPATRY; FLOW; DIFFERENTIATION; WARBLER AB Understanding the interplay of dispersal and how it translates into gene flow is key to understanding population processes, and especially so for endangered species occupying fragmented habitats. In migratory songbirds, there is evidence that long-distance movement capabilities do not translate well into observed dispersal. Our objectives were to (i) define the fine-scale spatial genetic structure in endangered black-capped vireos to characterize dispersal patterns and (ii) to correlate dispersal dynamics to overall population genetic structure using a simulation approach. We sampled 160 individuals over 2 years to (i) describe the fine-scale genetic structuring and (ii) used this information to model scenarios to compare with actual data on change in population structuring over a 100-year interval. We found that black-capped vireos exhibit male philopatry and restricted dispersal distances, relative to females. Our simulations also support a sex-biased dispersal model. Additionally, we find that fragmentation related changes in rates of dispersal might be a likely cause for increasing levels of population structure over a 100-year period. We show that restricted sex-biased dispersal can explain population structuring in this species and that changes in dispersal rates due to fragmentation may be a continuing threat to genetic viability in this species. C1 [Athrey, Giri; Leberg, Paul L.] Univ Louisiana Lafayette, Dept Biol, Lafayette, LA 70504 USA. [Lance, Richard F.] USA, Environm Lab, Engineer Res & Dev Ctr, Waterways Expt Stn, Vicksburg, MS 39180 USA. [Athrey, Giri] Texas A&M Univ, Vector Biol Grp, College Stn, TX 77842 USA. RP Athrey, G (reprint author), Texas A&M Univ, Dept Entomol, 514 Minnie Belle Heep Bldg, College Stn, TX 77843 USA. EM giri.athrey@tamu.edu RI Athrey, Giridhar/H-4077-2011 OI Athrey, Giridhar/0000-0002-7396-5490 FU US Army 6.1 Threatened and Endangered Species program; National Geographic Society CRE FX We thank K. Barr, D. Lindsay, C. Goates, J. Hernandez, L. Butler and S. Pathikonda for help with sample collection. We thank Texas Parks and Wildlife Department, Kerr Wildlife Management Area and Stowers Ranch for access to field sites and logistical support. This study was funded by US Army 6.1 Threatened and Endangered Species program grant to Richard F. Lance and Paul L. Leberg, and a National Geographic Society CRE grant to Giri Athrey. NR 58 TC 4 Z9 4 U1 3 U2 26 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0962-1083 J9 MOL ECOL JI Mol. Ecol. PD SEP PY 2012 VL 21 IS 17 BP 4359 EP 4370 DI 10.1111/j.1365-294X.2012.05694.x PG 12 WC Biochemistry & Molecular Biology; Ecology; Evolutionary Biology SC Biochemistry & Molecular Biology; Environmental Sciences & Ecology; Evolutionary Biology GA 995XB UT WOS:000308047100018 PM 22747695 ER PT J AU Wang, H Yu, LL Lee, YH Shi, YM Hsu, A Chin, ML Li, LJ Dubey, M Kong, J Palacios, T AF Wang, Han Yu, Lili Lee, Yi-Hsien Shi, Yumeng Hsu, Allen Chin, Matthew L. Li, Lain-Jong Dubey, Madan Kong, Jing Palacios, Tomas TI Integrated Circuits Based on Bilayer MoS2 Transistors SO NANO LETTERS LA English DT Article DE Molybdenum disulfide (MoS2); transition metal dichalcogenides (TMD); two-dimensional (2D) electronics; integrated circuits; ring oscillator ID SINGLE-LAYER MOS2; THIN-FILM TRANSISTORS; CARBON NANOTUBE; MONOLAYER MOS2; ATOMIC LAYERS AB Two-dimensional (2D) materials, such as molybdenum disulfide (MoS2), have been shown to exhibit excellent electrical and optical properties. The semiconducting nature of MoS2 allows it to overcome the shortcomings of zero-bandgap graphene, while still sharing many of graphene's advantages for electronic and optoelectronic applications. Discrete electronic and optoelectronic components, such as field-effect transistors, sensors, and photodetectors made from few-layer MoS2 show promising performance as potential substitute of Si in conventional electronics and of organic and amorphous Si semiconductors in ubiquitous systems and display applications. An important next step is the fabrication of fully integrated multistage circuits and logic building blocks on MoS2 to demonstrate its capability for complex digital logic and high-frequency ac applications. This paper demonstrates an inverter, a NAND gate, a static random access memory, and a five-stage ring oscillator based on a direct-coupled transistor logic technology. The circuits comprise between 2 to 12 transistors seamlessly integrated side-by-side on a single sheet of bilayer MoS2. Both enhancement-mode and depletion-mode transistors were fabricated thanks to the use of gate metals with different work functions. C1 [Wang, Han; Yu, Lili; Lee, Yi-Hsien; Shi, Yumeng; Hsu, Allen; Kong, Jing; Palacios, Tomas] MIT, Dept Elect Engn & Comp Sci, Cambridge, MA 02139 USA. [Chin, Matthew L.; Dubey, Madan] USA, Res Lab, Adelphi, MD 20783 USA. [Lee, Yi-Hsien; Li, Lain-Jong] Acad Sinica, Inst Atom & Mol Sci, Taipei 11529, Taiwan. RP Wang, H (reprint author), MIT, Dept Elect Engn & Comp Sci, 77 Massachusetts Ave, Cambridge, MA 02139 USA. EM hanw@mtl.mit.edu; tpalacios@mit.edu RI Wang, Han/E-9063-2011; Li, Lain-Jong/D-5244-2011; Shi, Yumeng/A-7349-2012 OI Wang, Han/0000-0002-1543-2020; Li, Lain-Jong/0000-0002-4059-7783; Shi, Yumeng/0000-0002-9623-3778 FU Office of Naval Research (ONR); Microelectronics Advanced Research Corporation Focus Center for Materials, Structure and Device (MARCO MSD), National Science Foundation [NSF DMR 0845358]; Army Research Laboratory FX The authors are grateful to D. Antoniadis and L. Wei for discussions. The authors acknowledge financial support from the Office of Naval Research (ONR) Young Investigator Program, the Microelectronics Advanced Research Corporation Focus Center for Materials, Structure and Device (MARCO MSD), National Science Foundation (NSF DMR 0845358) and the Army Research Laboratory. This research has made use of the MIT MTL and Harvard CNS facilities. NR 38 TC 598 Z9 604 U1 92 U2 807 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1530-6984 J9 NANO LETT JI Nano Lett. PD SEP PY 2012 VL 12 IS 9 BP 4674 EP 4680 DI 10.1021/nl302015v PG 7 WC Chemistry, Multidisciplinary; Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied; Physics, Condensed Matter SC Chemistry; Science & Technology - Other Topics; Materials Science; Physics GA 002YW UT WOS:000308576000043 PM 22862813 ER PT J AU Wohl, E Barros, A Brunsell, N Chappell, NA Coe, M Giambelluca, T Goldsmith, S Harmon, R Hendrickx, JMH Juvik, J McDonnell, J Ogden, F AF Wohl, Ellen Barros, Ana Brunsell, Nathaniel Chappell, Nick A. Coe, Michael Giambelluca, Thomas Goldsmith, Steven Harmon, Russell Hendrickx, Jan M. H. Juvik, James McDonnell, Jeffrey Ogden, Fred TI The hydrology of the humid tropics SO NATURE CLIMATE CHANGE LA English DT Review ID CLIMATE-CHANGE; MONTANE WATERSHEDS; SATELLITE DATA; SOIL-MOISTURE; AMAZON BASIN; FOREST; CARBON; PRECIPITATION; SEDIMENT; RAINFALL AB Hydrological processes in the humid tropics differ from other regions in having greater energy inputs and faster rates of change, including human-induced change. Human influences on population growth, land use and climate change will profoundly influence tropical hydrology, yet understanding of key hydrological interactions is limited. We propose that efforts to collect tropical data should explicitly emphasize characterizing moisture and energy fluxes from below the ground surface into the atmosphere. Research needs to chiefly involve field-based characterizations and modelling of moisture cycling and catchment processes, as well as long-term data acquisition and organization. C1 [Wohl, Ellen] Colorado State Univ, Dept Geosci, Ft Collins, CO 80523 USA. [Barros, Ana] Duke Univ, Pratt Sch Engn, CIEMAS 2457, Durham, NC 27708 USA. [Brunsell, Nathaniel] Univ Kansas, Dept Geog, Lawrence, KS 66045 USA. [Chappell, Nick A.] Univ Lancaster, Lancaster Environm Ctr, Lancaster LA1 4YQ, England. [Coe, Michael] Woods Hole Res Ctr, Falmouth, MA 02540 USA. [Giambelluca, Thomas] Univ Hawaii Manoa, Dept Geog, Honolulu, HI 96822 USA. [Goldsmith, Steven] Villanova Univ, Dept Geog & Environm, Villanova, PA 19085 USA. [Harmon, Russell] ARL Army Res Off, Environm Sci Div, Res Triangle Pk, NC 27709 USA. [Hendrickx, Jan M. H.] New Mexico Inst Min & Technol, Socorro, NM 87801 USA. [Juvik, James] Univ Hawaii, Dept Geog & Environm Studies, Hilo, HI 96720 USA. [McDonnell, Jeffrey] Oregon State Univ, Dept Forest Engn Resources & Management, Corvallis, OR 97331 USA. [Ogden, Fred] Univ Wyoming, Dept Civil & Architectural Engn, Laramie, WY 82071 USA. RP Wohl, E (reprint author), Colorado State Univ, Dept Geosci, Ft Collins, CO 80523 USA. EM ellenw@cnr.colostate.edu RI Brunsell, Nathaniel/G-2904-2012; Chappell, Nick/E-3562-2014; Barros, Ana/A-3562-2011; OI Barros, Ana/0000-0003-4606-3106; Giambelluca, Thomas/0000-0002-6798-3780 FU US Army Research Office FX Funding for the March 2011 tropical hydrology workshop that formed the starting point for this paper was provided by the US Army Research Office. We thank H. Rogers for hosting the workshop, and J. DeLay, C. Downer, H. Elsenbeer, E. McDonald and S. Turnbull for discussions during the workshop. NR 97 TC 62 Z9 63 U1 7 U2 114 PU NATURE PUBLISHING GROUP PI LONDON PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND SN 1758-678X EI 1758-6798 J9 NAT CLIM CHANGE JI Nat. Clim. Chang. PD SEP PY 2012 VL 2 IS 9 BP 655 EP 662 DI 10.1038/NCLIMATE1556 PG 8 WC Environmental Sciences; Environmental Studies; Meteorology & Atmospheric Sciences SC Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences GA 009ME UT WOS:000309029100010 ER PT J AU Satya, RV Zavaljevski, N Reifman, J AF Satya, Ravi Vijaya Zavaljevski, Nela Reifman, Jaques TI A new strategy to reduce allelic bias in RNA-Seq readmapping SO NUCLEIC ACIDS RESEARCH LA English DT Article ID GENE-EXPRESSION; HAPLOTYPE MAP; SHORT READS; ALIGNMENT; GENOME AB Accurate estimation of expression levels from RNA-Seq data entails precise mapping of the sequence reads to a reference genome. Because the standard reference genome contains only one allele at any given locus, reads overlapping polymorphic loci that carry a non-reference allele are at least one mismatch away from the reference and, hence, are less likely to be mapped. This bias in read mapping leads to inaccurate estimates of allele-specific expression (ASE). To address this read-mapping bias, we propose the construction of an enhanced reference genome that includes the alternative alleles at known polymorphic loci. We show that mapping to this enhanced reference reduced the read-mapping biases, leading to more reliable estimates of ASE. Experiments on simulated data show that the proposed strategy reduced the number of loci with mapping bias by epsilon 63% when compared with a previous approach that relies on masking the polymorphic loci and by epsilon 18% when compared with the standard approach that uses an unaltered reference. When we applied our strategy to actual RNA-Seq data, we found that it mapped up to 15% more reads than the previous approaches and identified many seemingly incorrect inferences made by them. C1 [Satya, Ravi Vijaya; Zavaljevski, Nela; Reifman, Jaques] USA, Med Res & Materiel Command, DoD Biotechnol High Performance Comp Software App, Telemed & Adv Technol Res Ctr, Ft Detrick, MD 21702 USA. RP Satya, RV (reprint author), USA, Med Res & Materiel Command, DoD Biotechnol High Performance Comp Software App, Telemed & Adv Technol Res Ctr, Ft Detrick, MD 21702 USA. EM ravi.vijayasatya@gmail.com; jaques.reifman@us.army.mil FU United States (U.S.) Department of Defense (DoD) under the High Performance Computing Software Applications Institutes Initiative FX Funding for open access charge: United States (U.S.) Department of Defense (DoD) High Performance Computing Modernization Program, under the High Performance Computing Software Applications Institutes Initiative. NR 19 TC 37 Z9 37 U1 2 U2 25 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 0305-1048 J9 NUCLEIC ACIDS RES JI Nucleic Acids Res. PD SEP PY 2012 VL 40 IS 16 AR e127 DI 10.1093/nar/gks425 PG 9 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA 008LZ UT WOS:000308959800008 PM 22584625 ER PT J AU Chung, W Goeckeler-Fried, J Brodsky, J Havasi, V Rowe, SM Piazza, GA Keeton, AB Sorscher, EJ AF Chung, W. Goeckeler-Fried, J. Brodsky, J. Havasi, V Rowe, S. M. Piazza, G. A. Keeton, A. B. Sorscher, E. J. TI AVAILABILITY OF F508DEL CFTR FOR SMALL MOLECULE CORRECTION SO PEDIATRIC PULMONOLOGY LA English DT Meeting Abstract C1 [Chung, W.; Havasi, V; Rowe, S. M.; Sorscher, E. J.] Univ Alabama Birmingham, Cyst Fibrosis Res Ctr, Birmingham, AL USA. [Goeckeler-Fried, J.; Brodsky, J.] Univ Pittsburgh, Pittsburgh, PA USA. [Piazza, G. A.; Keeton, A. B.] USA, Mitchell Canc Inst, Mobile, AL USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 8755-6863 J9 PEDIATR PULM JI Pediatr. Pulmonol. PD SEP PY 2012 VL 47 SU 35 SI SI BP 224 EP 224 PG 1 WC Pediatrics; Respiratory System SC Pediatrics; Respiratory System GA 007IM UT WOS:000308882000091 ER PT J AU Cozza, KL Wynn, GH AF Cozza, Kelly L. Wynn, Gary H. TI Smoking and Metabolism; Asenapine; Irreversible MAOIs SO PSYCHOSOMATICS LA English DT Editorial Material C1 [Cozza, Kelly L.] Walter Reed Natl Mil Med Ctr, Dept Psychiat, Bethesda, MD USA. [Wynn, Gary H.] Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0033-3182 J9 PSYCHOSOMATICS JI Psychosomatics PD SEP-OCT PY 2012 VL 53 IS 5 BP 499 EP 502 PG 4 WC Psychiatry; Psychology SC Psychiatry; Psychology GA 009MN UT WOS:000309030000016 PM 23126004 ER PT J AU Friedrich, BM Trefry, JC Biggins, JE Hensley, LE Honko, AN Smith, DR Olinger, GG AF Friedrich, Brian M. Trefry, John C. Biggins, Julia E. Hensley, Lisa E. Honko, Anna N. Smith, Darci R. Olinger, Gene G. TI Potential Vaccines and Post-Exposure Treatments for Filovirus Infections SO VIRUSES-BASEL LA English DT Review DE filovirus; Ebola; ebolavirus; Marburg virus; marburgvirus; vaccines; post-exposure treatments; clinical trials; non-human primates; animal models ID EBOLA-VIRUS INFECTION; NIEMANN-PICK C1; ANTIBODY-DEPENDENT ENHANCEMENT; PROTECTS NONHUMAN-PRIMATES; EQUINE ENCEPHALITIS-VIRUS; RESPIRATORY SYNDROME CORONAVIRUS; ANTISENSE MORPHOLINO OLIGOMERS; ADENOVIRUS-BASED VACCINE; T-CELL RESPONSES; HEMORRHAGIC-FEVER AB Viruses of the family Filoviridae represent significant health risks as emerging infectious diseases as well as potentially engineered biothreats. While many research efforts have been published offering possibilities toward the mitigation of filoviral infection, there remain no sanctioned therapeutic or vaccine strategies. Current progress in the development of filovirus therapeutics and vaccines is outlined herein with respect to their current level of testing, evaluation, and proximity toward human implementation, specifically with regard to human clinical trials, nonhuman primate studies, small animal studies, and in vitro development. Contemporary methods of supportive care and previous treatment approaches for human patients are also discussed. C1 [Friedrich, Brian M.; Trefry, John C.; Biggins, Julia E.; Honko, Anna N.; Smith, Darci R.; Olinger, Gene G.] USA, Med Res Inst Infect Dis, Div Virol, Frederick, MD 21702 USA. [Hensley, Lisa E.] US FDA, Med Sci Countermeasures Initiat McMi, Silver Spring, MD 20901 USA. RP Olinger, GG (reprint author), USA, Med Res Inst Infect Dis, Div Virol, 1425 Porter St, Frederick, MD 21702 USA. EM brian.m.friedrich.ctr@us.army.mil; john.c.trefry.ctr@us.army.mil; julia.biggins@us.army.mil; lisa.hensley@fda.hhs.gov; anna.honko@us.army.mil; darci.smith1@us.army.mil; Gene.olinger@us.army.mil OI Olinger, Gene/0000-0001-7338-0292; Honko, Anna/0000-0001-9165-148X FU JSTO-NRC CBD postdoctoral funds from DTRA; Department of Defense Chemical and Biological Defense Program [TMTI0017_09_RD_T]; DTRA [CBCALL12-THRFDA1-2-0135] FX BMF and JCT are National Research Council (NRC) postdoctoral fellows. BMF is also funded by JSTO-NRC CBD postdoctoral funds from DTRA. ANH is partially supported by Joint Project Management Office for Transformational Medical Technologies agreement TMTI0017_09_RD_T from the Department of Defense Chemical and Biological Defense Program. GGO is supported by the DTRA grant CBCALL12-THRFDA1-2-0135. NR 176 TC 25 Z9 29 U1 0 U2 36 PU MDPI AG PI BASEL PA POSTFACH, CH-4005 BASEL, SWITZERLAND SN 1999-4915 J9 VIRUSES-BASEL JI Viruses-Basel PD SEP PY 2012 VL 4 IS 9 BP 1619 EP 1650 DI 10.3390/v4091619 PG 32 WC Virology SC Virology GA 012XF UT WOS:000309269300014 PM 23170176 ER PT J AU Gui, F James, J Sridhar, N AF Gui, F. James, J. Sridhar, N. TI Corrosion Study of Carbon Steel in Biodiesel and Water Mixture Using Multielectrode Array SO CORROSION LA English DT Article DE biodiesel; carbon steel; corrosion; electrochemical; multielectrode array AB The demand for biodiesel and biodiesel blends as a fuel source has increased exponentially in the last decade. Water is the most significant contaminant in biodiesel-handling facilities (pipeline, storage tanks on the land, and fuel storage tanks on ships). Corrosion performance of materials in these facilities in biodiesel needs to be understood well to ascertain the facility integrity. The highly resistive nature of biodiesel imposes a great challenge in using the conventional electrochemical techniques for corrosion evaluation, even in the presence of water. Multielectrode array technique was demonstrated to be useful in evaluating the corrosion of steel in both the biodiesel phase and the water phase that is overlaid by the biodiesel phase. This work demonstrated that the corrosion rate in biodiesel phase is low. However, the biodiesel does influence the corrosion rate in the water phase when it is in contact. Appreciable corrosion was observed on the steel exposed to the water phase below a biodiesel layer, likely because of the diffusion of corrosive species (e.g., chloride) from the biodiesel phase into the water phase. C1 [Gui, F.; James, J.; Sridhar, N.] USA, DNV, Dublin, OH 43017 USA. RP Gui, F (reprint author), USA, DNV, 5777 Frantz Rd, Dublin, OH 43017 USA. EM feng.gui@dnv.com FU Pipeline Hazardous Materials and Safety Administration (PHMSA); DNV Research Innovation FX The authors would like acknowledge the financial support from the Pipeline Hazardous Materials and Safety Administration (PHMSA) and DNV Research & Innovation. The support from T. Place (Enbridge Pipelines) and J. Haas (Colonial Pipeline) in obtaining diesel samples is gratefully acknowledged. NR 18 TC 3 Z9 3 U1 1 U2 10 PU NATL ASSOC CORROSION ENG PI HOUSTON PA 1440 SOUTH CREEK DRIVE, HOUSTON, TX 77084-4906 USA SN 0010-9312 J9 CORROSION JI Corrosion PD SEP PY 2012 VL 68 IS 9 BP 827 EP 834 DI 10.5006/0591 PG 8 WC Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Materials Science; Metallurgy & Metallurgical Engineering GA 000TH UT WOS:000308411000007 ER PT J AU Fowler, M Garza, TH Slater, TM Maani, CV McGhee, LL AF Fowler, Marice Garza, Thomas H. Slater, Terry M. Maani, Christopher V. McGhee, Laura L. TI The Relationship Between Gabapentin and Pregabalin and Posttraumatic Stress Disorder in Burned Servicemembers SO JOURNAL OF BURN CARE & RESEARCH LA English DT Article ID ANTIEPILEPTIC DRUGS; ANXIETY DISORDERS; NEUROPATHIC PAIN; PTSD CHECKLIST; SOLDIERS; SYMPTOMS; VETERANS; MEMBERS; COMBAT; PHARMACOTHERAPY AB Posttraumatic stress disorder (PTSD) affects approximately 30% of burned Servicemembers returning from Operation Iraqi Freedom/Operation Enduring Freedom. Gabapentin and pregabalin are anticonvulsant drugs that limited evidence suggests may also be effective treatments for some psychological disorders. This study examines the relationship between these anticonvulsants and PTSD development in burned Servicemembers. Drugs received, injury severity score, TBSA burned, length of hospital stay, number of intensive care unit days, number of surgeries, and PTSD Checklist-Military scores and administration dates were collected. Subjects were grouped based on receipt of gabapentin or pregabalin, and the groups were compared. The primary outcome was incidence of a positive screen for PTSD. Because injury severity was significantly different between the two groups, propensity score matching based on injury severity score and TBSA was performed. Two hundred ninety burned Servicemembers received the PTSD Checklist-Military at least 30 days after injury. Of these subjects, 104 received gabapentin, pregabalin, or both and 186 did not. Despite significantly greater injuries, the group that received gabapentin or pregabalin did not develop PTSD at a different rate than those patients who did (P = .727). Propensity score matching resulted in 57 patients in each group; there was no difference between these groups in the incidence of PTSD (P = .663). These data suggest that gabapentin or pregabalin administration may not affect PTSD development in burned Servicemembers. Many factors influence the development and progression of PTSD, but few drugs have been identified that are effective at treating or preventing PTSD. (J Burn Care Res 2012;33:612-618) C1 [Fowler, Marice] USA, Inst Surg Res, Battlefield Pain Control Area, Ft Sam Houston, TX 78234 USA. RP Fowler, M (reprint author), USA, Inst Surg Res, Battlefield Pain Control Area, 3698 Chambers Pass, Ft Sam Houston, TX 78234 USA. FU US Army Institute of Surgical Research Battlefield Pain Control Research Area FX Supported by the US Army Institute of Surgical Research Battlefield Pain Control Research Area. NR 59 TC 3 Z9 3 U1 0 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1559-047X J9 J BURN CARE RES JI J. Burn Care Res. PD SEP-OCT PY 2012 VL 33 IS 5 BP 612 EP 618 DI 10.1097/BCR.0b013e31823dc710 PG 7 WC Emergency Medicine; Dermatology; Surgery SC Emergency Medicine; Dermatology; Surgery GA 004VG UT WOS:000308708700012 PM 22210072 ER PT J AU Johnson, M Sidow, SJ Looney, SW Lindsey, K Niu, LN Tay, FR AF Johnson, Meenal Sidow, Stephanie J. Looney, Stephen W. Lindsey, Kimberly Niu, Li-na Tay, Franklin R. TI Canal and Isthmus Debridement Efficacy Using a Sonic Irrigation Technique in a Closed-canal System SO JOURNAL OF ENDODONTICS LA English DT Article DE Closed system; collagen; isthmus; side-vented needle; sonic irrigation ID BIO-MOLECULAR FILM; EX-VIVO MODEL; ENDODONTIC TREATMENT; BACTERIOLOGIC EVALUATION; APICAL PERIODONTITIS; AGITATION TECHNIQUES; SODIUM-HYPOCHLORITE; BACTERIAL REDUCTION; IN-VITRO; ROOT AB Introduction: This in vitro study compared debridement efficacies of a sonic irrigation technique (Vibringe; Cavex Holland BV, Haarlem, The Netherlands) with side-vented needle irrigation (SNI) in the mesiobuccal root of maxillary first molars. Methods: Twenty roots with narrow isthmuses (<= 1/4 canal diameter) were selected using micro-computed tomography scanning. Collagen solution was injected into canals/isthmuses and reconstituted with NH4OH to simulate canal debris. Each root was sealed apically and embedded in polyvinyl siloxane simulating a closed-canal system. Canals were instrumented to size 40/.04 taper 1 mm short of the anatomic apex. The final irrigation was performed with the Vibringe or SNI. Roots were demineralized, sectioned at 6 levels (1.2-3.2 mm) from the anatomic apex, and stained using Masson trichrome stain. The areas occupied by canals and isthmus and the debris-containing areas were statistically analyzed with repeated-measures analyses using "irrigation technique" as the between factor and "canal level" as the within factor (alpha = 0.05). Results: Canals had significantly more debris at 1.2 and 1.6 mm (P < .001), but there was no overall difference between the 2 techniques (P = .561). Significant differences were found between the Vibringe and SNI at 2.4, 2.8, and 3.2 mm (P < .05). There was no significant difference in the remaining debris in the isthmus for SNI at all (P > .05). Considerably more debris remained at 1.2 and 2.0 mm for the Vibringe (P < .05). A significant difference was observed between the canal and the isthmus (P < .001). Conclusions: There is no difference between the Vibringe and SNI in their overall debridement efficacy, in apical one third of the mesiobuccal root of maxillary first molars. (J Endod 2012;38:1265-1268) C1 [Johnson, Meenal; Sidow, Stephanie J.; Lindsey, Kimberly] US Army Dent Act, Augusta, GA USA. [Looney, Stephen W.] Georgia Hlth Sci Univ, Dept Biostat, Augusta, GA USA. [Looney, Stephen W.] Georgia Hlth Sci Univ, Dept Oral Hlth & Diagnost Sci, Augusta, GA USA. [Niu, Li-na] Fourth Mil Med Univ, Sch Stomatol, Xian 710032, Peoples R China. [Tay, Franklin R.] Georgia Hlth Sci Univ, Coll Dent Med, Dept Endodont, Augusta, GA USA. RP Sidow, SJ (reprint author), US Army Dent Act, Dept Endodont, Ft Gordon, GA 30905 USA. EM stephanie.sidow@us.army.mil NR 34 TC 9 Z9 10 U1 3 U2 9 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0099-2399 J9 J ENDODONT JI J. Endod. PD SEP PY 2012 VL 38 IS 9 BP 1265 EP 1268 DI 10.1016/j.joen.2012.05.009 PG 4 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA 998ZF UT WOS:000308278200021 PM 22892748 ER PT J AU Peck, GW Kirkup, BC AF Peck, George W. Kirkup, Benjamin C. TI Biocompatibility of Antimicrobials to Maggot Debridement Therapy: Medical Maggots Lucilia sericata (Diptera: Calliphoridae) Exhibit Tolerance to Clinical Maximum Doses of Antimicrobials SO JOURNAL OF MEDICAL ENTOMOLOGY LA English DT Article DE Lucilia sericata; antibacterial; antileishmanial; antifungal; maggot therapy ID CUTANEOUS LEISHMANIASIS; PSEUDOMONAS-AERUGINOSA; STAPHYLOCOCCUS-AUREUS; BIOFILM FORMATION; MEDICINAL MAGGOT; EXCRETIONS; BACTERIA; EXCRETIONS/SECRETIONS; BIOMATERIALS; ANTIBIOTICS AB The larvae of calliphorid flies are used to debride wounds of patients with severe tissue destruction, often concurrently with antimicrobials. The current study evaluates the effects of ceftazidime, tobramycin, amikacin, gentamicin, polymyxin B, doxycycline, paromomycin, amphotericin B, sodium stibogluconate, and miltefosine at 1, 10, and 100 x the Maximum Clinical Concentration (mg/kg/d) in raw liver assays. Effects on larvae were small and depended on dose and antimicrobial formulation, with hours in assay (24 or 48 h) having a significant effect on larval survival. Sodium stibgluconate had the strongest effect on maggot survival (80.0% at 48 h). These results suggest that the antimicrobials tested here may be used simultaneously with maggot debridement therapy, and may actually increase the effectiveness of maggot debridement therapy in certain applications where >1 x Maximum Clinical Concentration is indicated, such as topical creams for cutaneous leishmaniasis. C1 [Peck, George W.; Kirkup, Benjamin C.] Walter Reed Army Inst Res, Wound Infect Dept, Bacterial Dis Branch, Silver Spring, MD 20910 USA. RP Peck, GW (reprint author), Walter Reed Army Inst Res, Wound Infect Dept, Bacterial Dis Branch, 530 Robert Grant Ave, Silver Spring, MD 20910 USA. EM george.peck@amedd.army.mil RI Kirkup, Benjamin/C-3610-2009 OI Kirkup, Benjamin/0000-0002-8722-6218 FU DMRDP [D10_I_AR_J2_561] FX We thank Rae A. Heitkamp for assistance rearing flies. This research was supported in part by a DMRDP grant (D10_I_AR_J2_561) to B.C.K. NR 40 TC 4 Z9 4 U1 1 U2 10 PU ENTOMOLOGICAL SOC AMER PI LANHAM PA 10001 DEREKWOOD LANE, STE 100, LANHAM, MD 20706-4876 USA SN 0022-2585 J9 J MED ENTOMOL JI J. Med. Entomol. PD SEP PY 2012 VL 49 IS 5 BP 1137 EP 1143 DI 10.1603/ME12066 PG 7 WC Entomology; Veterinary Sciences SC Entomology; Veterinary Sciences GA 007YK UT WOS:000308924100022 PM 23025196 ER PT J AU Martin, MJ DuBose, JJ Rodriguez, C Dorlac, WC Beilman, GJ Rasmussen, TE Jenkins, DH Holcomb, JB Pruitt, BA AF Martin, Matthew J. DuBose, Joseph J. Rodriguez, Carlos Dorlac, Warren C. Beilman, Greg J. Rasmussen, Todd E. Jenkins, Donald H. Holcomb, John B. Pruitt, Basil A. TI "One Front and One Battle": Civilian Professional Medical Support of Military Surgeons SO JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS LA English DT Editorial Material C1 [Martin, Matthew J.] Madigan Army Med Ctr, Dept Surg, Tacoma, WA 98431 USA. [DuBose, Joseph J.] Univ Maryland Med Syst, R Adams Cowley Shock Trauma Ctr, C STARS Baltimore, Baltimore, MD USA. [Rodriguez, Carlos] Natl Naval Med Ctr, Dept Surg, Bethesda, MD USA. [Dorlac, Warren C.] Univ Cincinnati, Sch Med, Dept Surg, Cincinnati, OH USA. [Beilman, Greg J.] Univ Minnesota, Dept Surg, Minneapolis, MN 55455 USA. [Rasmussen, Todd E.] Brooke Army Med Ctr, Dept Surg, San Antonio, TX USA. [Jenkins, Donald H.] Mayo Coll Med, Dept Surg, Rochester, MN USA. [Holcomb, John B.] Mem Hermman Texas Med Ctr, Dept Surg, Houston, TX USA. [Pruitt, Basil A.] Univ Texas San Antonio, San Antonio Med Ctr, Dept Surg, San Antonio, TX USA. RP DuBose, JJ (reprint author), Univ Maryland Med Syst R Adams Cowley Shock Traum, USAF MC, C STARS Baltimore, 22 S Greene St,T5R46, Baltimore, MD 21201 USA. EM jjd3c@yahoo.com RI Martin, Matthew/B-2676-2014; OI Martin, Matthew/0000-0002-9169-9069; Beilman, Gregory/0000-0001-5036-3027 NR 6 TC 3 Z9 3 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1072-7515 EI 1879-1190 J9 J AM COLL SURGEONS JI J. Am. Coll. Surg. PD SEP PY 2012 VL 215 IS 3 BP 432 EP 437 DI 10.1016/j.jamcollsurg.2012.03.025 PG 6 WC Surgery SC Surgery GA 007RY UT WOS:000308907000016 PM 22683071 ER PT J AU Ivey, KM White, CE Wallum, TE Cannon, JW Chung, KK McNeil, JD Cohn, SM Blackbourne, LH AF Ivey, Katherine M. White, Christopher E. Wallum, Timothy E. Cannon, Jeremy W. Chung, Kevin K. McNeil, Jeffrey D. Cohn, Stephen M. Blackbourne, Lorne H. TI Thoracic injuries in US combat casualties: A review of Operation Enduring Freedom and Operation Iraqi Freedom SO JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS LA English DT Meeting Abstract CT 98th Annual Clinical Congress of the American-College-of-Surgeons/67th Annual Sessions of the Owen H Wangensteen Forum on Fundamental Surgical Problems CY SEP 30-OCT 04, 2012 CL Chicago, IL SP Amer Coll Surg C1 [Ivey, Katherine M.; White, Christopher E.; Wallum, Timothy E.; Cannon, Jeremy W.; Chung, Kevin K.; McNeil, Jeffrey D.; Cohn, Stephen M.; Blackbourne, Lorne H.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1072-7515 J9 J AM COLL SURGEONS JI J. Am. Coll. Surg. PD SEP PY 2012 VL 215 IS 3 SU S BP S44 EP S45 PG 2 WC Surgery SC Surgery GA 007SX UT WOS:000308909600085 ER PT J AU Kellicut, DC Kuncir, E Williamson, HM Nielsen, PE AF Kellicut, Dwight C. Kuncir, Eric Williamson, Hope M. Nielsen, Peter E. TI Surgical Team Assessment Training (STAT): Improving surgical teams during deployment SO JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS LA English DT Meeting Abstract CT 98th Annual Clinical Congress of the American-College-of-Surgeons/67th Annual Sessions of the Owen H Wangensteen Forum on Fundamental Surgical Problems CY SEP 30-OCT 04, 2012 CL Chicago, IL SP Amer Coll Surg C1 Madigan Army Med Ctr, Tacoma, WA 98431 USA. Tripler Army Med Ctr, Honlulu, HI USA. NR 0 TC 1 Z9 1 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1072-7515 J9 J AM COLL SURGEONS JI J. Am. Coll. Surg. PD SEP PY 2012 VL 215 IS 3 SU S BP S100 EP S100 PG 1 WC Surgery SC Surgery GA 007SX UT WOS:000308909600215 ER PT J AU Krueger, CA Wenke, JC Masini, BD Stinner, DJ AF Krueger, Chad A. Wenke, Joseph C. Masini, Brendan D. Stinner, Daniel J. TI Characteristics and Impact of Animal Models Used for Sports Medicine Research SO ORTHOPEDICS LA English DT Article ID ANTERIOR CRUCIATE LIGAMENT; BIOMECHANICAL EVALUATION; MECHANICAL-PROPERTIES; FIXATION; REPAIR; CARTILAGE; HISTOLOGY; HUMANS; INJURY; TENDON AB Animal models are commonly used for translational research despite evidence that the methodology of these studies is often inconsistent and substandard. This study describes the characteristics and impact of published research using animal models in the American Journal of Sports Medicine (AJSM). Peer-reviewed articles published in the AJSM between January 1990 and January 2010 using animal models were identified using MEDLINE. The articles were reviewed for funding source, anesthesia used, animal used, study type, study location, outcome measures, number of animals, duration of animal survival, main topic being studied, and positive or negative treatment effect. The impact factor of the studies published between 2005 and 2010 was calculated. Two hundred fifty-seven articles, or 6% (257/4278) of the total publications during the 20-year period, were analyzed. The impact factor increased from 1.83 in 2005 to 3.9 in 2010. The most common animals used were rabbits (24%) and pigs (16%). The anterior cruciate ligament was studied in 34% of the articles, and a pig model was used for 31% of these studies. Eighty-six percent of the studies had a positive treatment effect. This study shows that animal models used in sports medicine research lack uniformity in their methods and suggests that a publication bias may exist for animal research in the sports medicine literature. C1 [Krueger, Chad A.; Masini, Brendan D.; Stinner, Daniel J.] Brooke Army Med Ctr, Dept Orthopaed & Rehabil, Ft Sam Houston, TX 78234 USA. [Wenke, Joseph C.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Krueger, CA (reprint author), Brooke Army Med Ctr, Dept Orthopaed & Rehabil, 3851 Rogers Brooke Dr, Ft Sam Houston, TX 78234 USA. EM chad.krueger@amedd.army.mil OI Stinner, Daniel/0000-0002-8981-6262 NR 29 TC 3 Z9 3 U1 0 U2 4 PU SLACK INC PI THOROFARE PA 6900 GROVE RD, THOROFARE, NJ 08086 USA SN 0147-7447 J9 ORTHOPEDICS JI Orthopedics PD SEP PY 2012 VL 35 IS 9 BP E1410 EP E1415 DI 10.3928/01477447-20120822-30 PG 6 WC Orthopedics SC Orthopedics GA 007TL UT WOS:000308911100018 PM 22955410 ER PT J AU Krueger, CA Shakir, I Fuller, BC AF Krueger, Chad A. Shakir, Irshad Fuller, Brian C. TI Prevalence of Answers to Orthopaedic In-Training Examination Questions in 3 Commonly Used Orthopedic Review Sources SO ORTHOPEDICS LA English DT Review ID EDUCATIONAL-TOOL; EXAMINATION OITE; TRAUMA SECTION; PERFORMANCE; SCORES AB One of the greatest predictors for resident success on the Orthopaedic In-Training Examination (OITE) is reviewing previous OITE questions. However, no studies have examined which review sources contain the most answers to previously asked OITE questions. The goal of this study was to determine which review source contains the most answers to previously asked OITE questions. Each question from the 2006 to 2010 OITEs was examined. The questions were placed into 1 of 13 categories based on their topic. The publication date of the recommended readings associated with each question was recorded. The answer to each question was then searched for in 3 commonly used review sources: Miller's Review of Orthopaedics, 5th edition (MRO), American Academy of Orthopaedic Surgeons Comprehensive Orthopaedic Review (COR), and www.orthobullets.com (OB). Searchable electronic versions of each textbook were used, and each question had a 12-minute time limit. Of 1358 questions, 665 (49%) were found in all 3 sources. Significantly more answers were found on OB (99.4%) compared with MRO (60%) and COR (62%) (P <.0001). Significantly more answers to questions in each question category were found on OB compared with MRO or COR (P <.0001). More than 50% of all recommended readings for OITE questions were published within 5 years of the OITE. Residents using OB to review for the OITE will be exposed to significantly more answers of previously asked OITE questions than residents using MRO or COR (P <.0001). C1 [Krueger, Chad A.; Fuller, Brian C.] Brooke Army Med Ctr, Dept Orthopaed Surg & Rehabil, Ft Sam Houston, TX 78234 USA. [Shakir, Irshad] St Louis Univ, Sch Med, Dept Orthopaed Surg, St Louis, MO USA. RP Krueger, CA (reprint author), Brooke Army Med Ctr, Dept Orthopaed Surg & Rehabil, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM chad.krueger@amedd.army.mil NR 25 TC 3 Z9 3 U1 0 U2 0 PU SLACK INC PI THOROFARE PA 6900 GROVE RD, THOROFARE, NJ 08086 USA SN 0147-7447 J9 ORTHOPEDICS JI Orthopedics PD SEP PY 2012 VL 35 IS 9 BP E1420 EP E1426 DI 10.3928/01477447-20120822-32 PG 7 WC Orthopedics SC Orthopedics GA 007TL UT WOS:000308911100020 PM 22955412 ER PT J AU Mu, TS Palmer, EG Batts, SG Lentz-Kapua, SL Uyehara-Lock, JH Uyehara, CFT AF Mu, Thornton S. Palmer, Eldon G. Batts, Sherreen G. Lentz-Kapua, Sarah L. Uyehara-Lock, Jane H. Uyehara, Catherine F. T. TI Continuous renal replacement therapy to reduce inflammation in a piglet hemorrhage-reperfusion extracorporeal membrane oxygenation model SO PEDIATRIC RESEARCH LA English DT Article ID MECONIUM ASPIRATION SYNDROME; CARDIOPULMONARY BYPASS; BRONCHOALVEOLAR LAVAGE; CYTOKINE RELEASE; INFANTS; HEMOFILTRATION; ACTIVATION; PULMONARY; FAILURE; INJURY AB BACKGROUND: During extracorporeal membrane oxygenation (ECMO), circulation of blood across synthetic surfaces triggers an inflammatory response. Therefore, we evaluated the ability of continuous renal replacement therapy (CRRT) to remove cytokines and reduce the inflammatory response in a piglet hemorrhage-reperfusion ECMO model. METHODS: Three groups were studied: (i) uninjured controls (n = 11); (ii) hemorrhage-reperfusion while on veno-arterial ECMO (30% hemorrhage with subsequent blood volume replacement within 60 min) (n = 8); (iii) treatment with CRRT after hemorrhage-reperfusion while on ECMO (n = 7). Hemodynamic parameters, oxygen utilization, and plasma and broncho-alveolar lavage (BAL) cytokine levels were recorded and lung tissue samples collected for histologic comparison. RESULTS: Whereas mean arterial pressures decreased among hemorrhage-reperfusion piglets, ECMO with CRRT did not significantly alter mean arterial pressures or systemic vascular resistance and was able to maintain blood flow as well as oxygen delivery after hemorrhage-reperfusion. Plasma interleukin (IL)-6 and IL-10, and BAL tumor necrosis factor (TNF)-alpha, IL-1 beta, IL-6, IL-8, and IL-10 increased as a result of hemorrhage-reperfusion while on ECMO. After a 6-h period of CRRT, plasma IL-6 and BAL TNF-alpha, IL-6, and IL-8 levels decreased. CONCLUSION: Data suggest CRRT may decrease inflammatory cytokine levels during the initial phase of ECMO therapy following hemorrhage-reperfusion while maintaining cardiac output and oxygen utilization. C1 [Mu, Thornton S.; Palmer, Eldon G.; Batts, Sherreen G.; Lentz-Kapua, Sarah L.] Tripler Army Med Ctr, Dept Pediat, Honolulu, HI 96859 USA. [Uyehara-Lock, Jane H.] Univ Hawaii, John A Burns Sch Med, Dept Pathol, Honolulu, HI 96822 USA. [Uyehara, Catherine F. T.] Tripler Army Med Ctr, Dept Clin Invest, Honolulu, HI 96859 USA. RP Mu, TS (reprint author), Tripler Army Med Ctr, Dept Pediat, Honolulu, HI 96859 USA. EM thornton.mu@amedd.army.mil FU US Army Medical Research and Material Command Core Research Program; FY08 War Supplemental Intramural Research Program; Congressionally Directed Medical Research Program [W23RYX6200N602] FX This work was supported, in part, by the US Army Medical Research and Material Command Core Research Program, FY08 War Supplemental Intramural Research Program, and Congressionally Directed Medical Research Program grant W23RYX6200N602. NR 28 TC 13 Z9 16 U1 0 U2 3 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 0031-3998 J9 PEDIATR RES JI Pediatr. Res. PD SEP PY 2012 VL 72 IS 3 BP 249 EP 255 DI 10.1038/pr.2012.69 PG 7 WC Pediatrics SC Pediatrics GA 999AC UT WOS:000308280500004 PM 22669297 ER PT J AU Matis, M AF Matis, Michael TI The Protection of Undersea Cables: A Global Security Threat SO SEA TECHNOLOGY LA English DT Editorial Material C1 [Matis, Michael] USA, War College, Washington, DC 20310 USA. RP Matis, M (reprint author), USA, War College, Washington, DC 20310 USA. NR 0 TC 0 Z9 0 U1 1 U2 3 PU COMPASS PUBLICATIONS, INC PI ARLINGTON PA 1501 WILSON BLVD., STE 1001, ARLINGTON, VA 22209-2403 USA SN 0093-3651 J9 SEA TECHNOL JI Sea Technol. PD SEP PY 2012 VL 53 IS 9 BP 89 EP 89 PG 1 WC Engineering, Ocean SC Engineering GA 009JE UT WOS:000309021300009 ER PT J AU Knox, JB Orchowski, JR Owens, B AF Knox, Jeffrey B. Orchowski, Joseph R. Owens, Brett TI Racial Differences in the Incidence of Acute Low Back Pain in United States Military Service Members SO SPINE LA English DT Article DE race; epidemiology; low back pain ID DISC DEGENERATION; RISK-FACTORS; NECK PAIN; PREVALENCE; CONSULTATION; POPULATION AB Study Design. An epidemiological study. Objective. To determine the effect of race on the incidence of acute low back pain, resulting in a health care encounter in active duty military service members. Summary of Background Data. Although racial differences in the incidence of low back pain have been documented in previous studies, currently no consensus exists on the relative risk between these groups. Methods. A query was performed using the Armed Forces Health Surveillance Center database for the International Classification of Diseases, Ninth Revision code for low back pain (724.20). A total of 12,399,276 person-years of data were analyzed and stratified by age, race, and sex. Incidence rates were calculated and compared using the multivariate Poisson regression analysis. Results. A total of 467,950 cases of low back pain resulted in a visit to a health care provider in our population, with an overall incidence rate of 37.74 per 1000 person-years. Asians/Pacific Islanders had the lowest incidence rate of 30.7 and blacks had the highest with 43.7. Female sex and older age were also significant risk factors but with significantly different effect sizes between racial groups. Native Americans/Alaskan Natives demonstrated the greatest effect of age on low back pain incidence rates, with a 126% increase between the youngest and oldest age groups compared with a 36% difference in whites. Conclusion. Race, sex, and age were all found to be significant risk factors for acute low back pain. The highest rates were identified in blacks followed by whites, Hispanics, and American Indian/Alaskan Native, and the lowest rates were identified in Asians/Pacific Islanders. Significant differences in the effect of sex and age were identified between the different racial groups. C1 [Knox, Jeffrey B.; Orchowski, Joseph R.] Tripler Army Med Ctr, Dept Surg, Orthopaed Surg Serv, Honolulu, HI 96859 USA. [Owens, Brett] Keller Army Hosp, Orthopaed Surg Serv, Dept Surg, West Point, NY USA. RP Knox, JB (reprint author), Tripler Army Med Ctr, Dept Surg, Orthopaed Surg Serv, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM jeffrey.bruce.knox@us.army.mil NR 16 TC 10 Z9 10 U1 0 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0362-2436 J9 SPINE JI SPINE PD SEP 1 PY 2012 VL 37 IS 19 BP 1688 EP 1692 DI 10.1097/BRS.0b013e318255a07b PG 5 WC Clinical Neurology; Orthopedics SC Neurosciences & Neurology; Orthopedics GA 999YR UT WOS:000308352300019 PM 22460922 ER PT J AU Stromdahl, EY Hickling, GJ AF Stromdahl, E. Y. Hickling, G. J. TI Beyond Lyme: Aetiology of Tick-borne Human Diseases with Emphasis on the South-Eastern United States SO ZOONOSES AND PUBLIC HEALTH LA English DT Review DE Emerging infectious disease; ehrlichiosis; lyme disease; rickettsiosis; tick-borne disease ID AMBLYOMMA-AMERICANUM ACARI; LONE-STAR TICK; MOUNTAIN-SPOTTED-FEVER; IXODES-SCAPULARIS ACARI; GULF-COAST TICKS; TRANSFUSION-ASSOCIATED BABESIOSIS; BORRELIA-LONESTARI DNA; WHITE-TAILED DEER; BROWN DOG TICK; DERMACENTOR-VARIABILIS AB Since its emergence in the north-eastern and upper mid-western United States in the 1970s, Lyme disease, caused by Borrelia burgdorferi, has captured the publics attention as the nations most prevalent vector-borne zoonotic disease. In contrast, recent publications on tick-pathogen systems in the eastern United States, and findings from Department of Defense investigations of ticks found biting military personnel, indicate that residents of the south-eastern United States are primarily at risk from emerging diseases caused by tick-borne pathogens other than B.burgdorferi. The risk of contracting these diseases varies greatly among states as a consequence of regional variation in the abundance of the key vector tick species. Moreover, this risk is changing, because tick distributions are in flux. To improve health outcomes, health providers need better information and awareness regarding which tick species bite humans in each state and which zoonotic pathogens are prevalent in these ticks. Effective diagnosis, treatment, control and reporting of tick-borne disease in the south-eastern United States require that health providers think beyond Lyme and consider the marked regional differences in the tick species that bite humans and in the pathogens that these ticks carry. C1 [Hickling, G. J.] Univ Tennessee, Inst Agr, Ctr Wildlife Hlth, Knoxville, TN 37996 USA. [Stromdahl, E. Y.] USA, Publ Hlth Command, Army Inst Publ Hlth, Aberdeen Proving Ground, MD USA. RP Hickling, GJ (reprint author), Univ Tennessee, Inst Agr, Ctr Wildlife Hlth, 274 Ellington Plant Sci, Knoxville, TN 37996 USA. EM ghicklin@utk.edu FU National Science Foundation EEID Grant [0914397]; NIMBioS, the National Institute for Mathematical and Biological Synthesis FX We thank Drs Mark Eshoo and Chris Crowder of Ibis Bio-sciences, Carlsbad, California, and Dr Marcee Toliver, for allowing us to cite their unpublished data. Dr Jean Tsao, University of Michigan, Dr Jennifer McQuiston, CDC-Atlanta, Dr Barbara J. Johnson and Ms Anna Perea, CDC-Ft. Collins and Dr Anne Kjemtrup, California Department of Public Health, provided insightful comments on drafts of the manuscript. Dr Joe Piesman and Ms. Gabrielle Dietrich, CDC-Ft. Collins, kindly supplied us with I. scapularis nymphs for high-resolution imaging. The views expressed in this article are those of the authors and do not reflect the official policy or position of the Department of the Army, Department of Defense, The National Science Foundation, or the US Government. GJH was supported in part by National Science Foundation EEID Grant No. 0914397 and by NIMBioS, the National Institute for Mathematical and Biological Synthesis. NR 132 TC 39 Z9 40 U1 1 U2 47 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1863-1959 J9 ZOONOSES PUBLIC HLTH JI Zoonoses Public Health PD SEP PY 2012 VL 59 SU 2 SI SI BP 48 EP 64 DI 10.1111/j.1863-2378.2012.01475.x PG 17 WC Public, Environmental & Occupational Health; Infectious Diseases; Veterinary Sciences SC Public, Environmental & Occupational Health; Infectious Diseases; Veterinary Sciences GA 003BB UT WOS:000308582000005 PM 22958250 ER PT J AU Watts, DB Arriaga, FJ Torbert, HA Gebhart, DL Busby, RR AF Watts, D. B. Arriaga, F. J. Torbert, H. A. Gebhart, D. L. Busby, R. R. TI Ecosystem Biomass, Carbon, and Nitrogen Five Years after Restoration with Municipal Solid Waste SO AGRONOMY JOURNAL LA English DT Article ID PROCESSING BY-PRODUCT; SOIL; COMPOST AB Escalating municipal solid waste generation coupled with decreasing landfill space needed for disposal has increased the pressure on military installations to evaluate novel approaches to handle this waste. One approach to alleviating the amount of municipal solid waste being landfilled is the use of a new garbage-processing technology that sterilizes and separates waste into inorganic and organic components. Thus, a study was initiated to evaluate the effectiveness of using the organic component (Fluff) as a soil amendment for establishing native prairie grasses on disturbed U.S.Army training land. The Fluff material was incorporated (10-20 cm) into a highly degraded sandy loam soil located in a borrow pit at Fort Benning Military Reservation, GA, in 2003. Th e Fluff was applied at rates of 0, 18, 36, 72, and 143 Mg ha(-1) and seeded with native prairie grasses to assess its effect on aboveground and belowground biomass production and C and N cycling aft er 5 yr. An unseeded control (no Fluff) treatment was also evaluated as a comparison of natural recovery. Aft er 5 yr, revegetation resulting from natural recovery in the unseeded control was sparse. However, Fluff addition improved native grass establishment, with greater biomass production being observed with increasing rates. Fluff addition also decreased soil bulk density and increased soil C and N concentrations. These results show that Fluff can be effectively used in land rehabilitation and revegetation practices as well as to improve C and N cycling of highly degraded soils for periods exceeding 5 yr aft er application. C1 [Watts, D. B.; Arriaga, F. J.; Torbert, H. A.] ARS, USDA, Natl Soil Dynam Lab, Auburn, AL 36832 USA. [Gebhart, D. L.; Busby, R. R.] USA, Engineer Res & Dev Ctr, Construct Engn Res Lab, Champaign, IL 61826 USA. RP Watts, DB (reprint author), ARS, USDA, Natl Soil Dynam Lab, 411 S Donahue Dr, Auburn, AL 36832 USA. EM Dexter.Watts@ars.usda.gov NR 22 TC 2 Z9 2 U1 1 U2 18 PU AMER SOC AGRONOMY PI MADISON PA 677 S SEGOE RD, MADISON, WI 53711 USA SN 0002-1962 J9 AGRON J JI Agron. J. PD SEP-OCT PY 2012 VL 104 IS 5 BP 1305 EP 1311 DI 10.2134/agronj2011.0347 PG 7 WC Agronomy SC Agriculture GA 999YT UT WOS:000308352600012 ER PT J AU Nissan, A Protic, M Bilchik, AJ Howard, RS Peoples, GE Stojadinovic, A AF Nissan, Aviram Protic, Mladjan Bilchik, Anton J. Howard, Robin S. Peoples, George E. Stojadinovic, Alexander TI United States Military Cancer Institute Clinical Trials Group (USMCI GI-01) Randomized Controlled Trial Comparing Targeted Nodal Assessment and Ultrastaging With Standard Pathological Evaluation for Colon Cancer SO ANNALS OF SURGERY LA English DT Article DE cancer recurrence; colon cancer; disease-free survival; lymph node; lymph node yield; quality indicator; sentinel node; staging; targeted nodal assessment ID PROSPECTIVE MULTICENTER TRIAL; SENTINEL LYMPH-NODES; COLORECTAL-CANCER; STAGING SYSTEM; TUMOR-CELLS; CARCINOMA; SURVIVAL; MICROMETASTASES; DISEASE; METAANALYSIS AB Objective: Our randomized controlled trial previously demonstrated improved staging accuracy with targeted nodal assessment and ultrastaging (TNA-us) in colon cancer (CC). Our objective was to test the hypothesis that TNA-us improves disease-free survival (DFS) in CC. Methods: In this nonblinded, group-sequential randomized controlled trial, 192 patients with CC were randomized to standard nodal evaluation (control) or TNA-us (intervention) in academic centers (August 2002-March 2010). The primary outcome (upstaging) was reported in 2007. The secondary outcome was DFS. The trial is closed, and the analysis of DFS is reported herein. Results: Clinical parameters of the control (n = 94) and TNA-us (n = 98) groups were comparable. Median (interquartile range) lymph node yield was higher in the TNA-us arm: 16 (12-22) versus 13 (10-18); P = 0.002. Median follow-up was 46 (29-70) months. Overall 5-year DFS was 61% in the control arm and 71% in the TNA-us arm (P = 0.11). Clinical parameters of node-negative patients in the control (n = 51) and TNA-us (n = 55) groups were comparable. Lymph node yield was higher in the TNA-us arm: 15 (12-21) versus 13 (8-18); P = 0.03. Five-year DFS differed significantly between groups with node-negative CC (control 71% vs TNA-us 86%; P = 0.04). Survival among stage II CC alone was alone was higher in the TNA-us group, 83% versus 65%; P = 0.03. Adjuvant chemotherapy use was nearly identical between groups. TNA-us stratified CC prognosis; DFS differed significantly between ultrastaged and conventionally staged node-negative patients [control pN0 72% vs TNA-us pN0(i-) 87%; P = 0.03]. Survival varied according to lymph node yield in patients with node-negative CC [5-year DFS: < 12 lymph nodes = 57% vs 12+ lymph nodes = 85%; P = 0.011] but not in stage III CC. Conclusions: TNA-us is associated with improved nodal diagnostic yield and enhanced staging accuracy (stage migration), which is further associated with improved DFS in early CC. This study is registered at clinicaltrials.gov under the registration number: NCT01623258. C1 [Stojadinovic, Alexander] Walter Reed Natl Mil Med Ctr, Dept Surg, Div Surg Oncol, Bethesda, MD 20899 USA. [Nissan, Aviram; Protic, Mladjan; Bilchik, Anton J.; Peoples, George E.; Stojadinovic, Alexander] US Mil Canc Inst, Washington, DC USA. [Protic, Mladjan] Clin Ctr Vojvodina, Clin Abdominal Endocrine & Transplantat Surg, Novi Sad, Serbia. [Protic, Mladjan] Univ Novi Sad, Fac Med, Novi Sad 21000, Serbia. [Bilchik, Anton J.] Univ Calif Los Angeles, Los Angeles, CA USA. [Bilchik, Anton J.] Calif Oncol Res Inst, Santa Monica, CA USA. [Howard, Robin S.] Walter Reed Natl Mil Med Ctr, Dept Res Programs, Biostat Sect, Bethesda, MD 20899 USA. [Peoples, George E.] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. [Stojadinovic, Alexander] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. RP Stojadinovic, A (reprint author), Walter Reed Natl Mil Med Ctr, Dept Surg, Div Surg Oncol, 8901 Wisconsin Ave,Bldg 9,Room 1272, Bethesda, MD 20899 USA. EM alexander.stojadinovic@med.navy.mil FU United States Military Cancer Institute (USMCI); NCI grant [RO1 CA090848]; Ultrastaging Early Colon Cancer; PI AJ Bilchik; California Oncology Research Institute FX Supported by the United States Military Cancer Institute (USMCI), NCI grant RO1 CA090848 Ultrastaging Early Colon Cancer, PI AJ Bilchik, and the California Oncology Research Institute. NR 42 TC 11 Z9 11 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0003-4932 EI 1528-1140 J9 ANN SURG JI Ann. Surg. PD SEP PY 2012 VL 256 IS 3 BP 412 EP 427 DI 10.1097/SLA.0b013e31826571c8 PG 16 WC Surgery SC Surgery GA 004HB UT WOS:000308670900013 PM 22871988 ER PT J AU Safronetz, D Ebihara, H Feldmann, H Hooper, JW AF Safronetz, David Ebihara, Hideki Feldmann, Heinz Hooper, Jay W. TI The Syrian hamster model of hantavirus pulmonary syndrome SO ANTIVIRAL RESEARCH LA English DT Review DE Hantavirus pulmonary syndrome; Andes virus; Bunyavirus; Hamster; Animal model ID HANTAAN VIRUS-INFECTION; SIN-NOMBRE-VIRUS; TO-PERSON TRANSMISSION; CREEK CANAL VIRUS; M GENOME SEGMENT; ANDES VIRUS; CARDIOPULMONARY SYNDROME; HEMORRHAGIC-FEVER; SUCKLING MICE; PUUMALA VIRUS AB Hantavirus pulmonary syndrome (HPS) is a relatively rare, but frequently fatal disease associated with New World hantaviruses, most commonly Sin Nombre and Andes viruses in North and South America, respectively. It is characterized by fever and the sudden, rapid onset of severe respiratory distress and cardiogenic shock, which can be fatal in up to 50% of cases. Currently there are no approved antiviral therapies or vaccines for the treatment or prevention of HPS. A major obstacle in the development of effective medical countermeasures against highly pathogenic agents like the hantaviruses is recapitulating the human disease as closely as possible in an appropriate and reliable animal model. To date, the only animal model that resembles HPS in humans is the Syrian hamster model. Following infection with Andes virus, hamsters develop HPS-like disease which faithfully mimics the human condition with respect to incubation period and pathophysiology of disease. Perhaps most importantly, the sudden and rapid onset of severe respiratory distress observed in humans also occurs in hamsters. The last several years has seen an increase in studies utilizing the Andes virus hamster model which have provided unique insight into HPS pathogenesis as well as potential therapeutic and vaccine strategies to treat and prevent HPS. The purpose of this article is to review the current understanding of HPS disease progression in Syrian hamsters and discuss the suitability of utilizing this model to evaluate potential medical countermeasures against HPS. (c) 2012 Elsevier B.V. All rights reserved. C1 [Safronetz, David; Ebihara, Hideki; Feldmann, Heinz] NIAID, Virol Lab, Div Intramural Res, NIH, Hamilton, MT 59840 USA. [Hooper, Jay W.] USA, Div Virol, Med Res Inst Infect Dis, Frederick, MD 21702 USA. RP Safronetz, D (reprint author), NIAID, Virol Lab, Div Intramural Res, NIH, 903 S 4th St, Hamilton, MT 59840 USA. EM safronetzd@niaid.nih.gov; jay.hooper@amedd.army.mil OI Hooper, Jay/0000-0002-4475-0415 FU Intramural NIH HHS [Z99 AI999999] NR 97 TC 26 Z9 26 U1 1 U2 17 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0166-3542 J9 ANTIVIR RES JI Antiviral Res. PD SEP PY 2012 VL 95 IS 3 BP 282 EP 292 DI 10.1016/j.antivira1.2012.06.002 PG 11 WC Pharmacology & Pharmacy; Virology SC Pharmacology & Pharmacy; Virology GA 002FM UT WOS:000308517500012 PM 22705798 ER PT J AU Wagner, L Verma, A Meade, BD Reiter, K Narum, DL Brady, RA Little, SF Burns, DL AF Wagner, Leslie Verma, Anita Meade, Bruce D. Reiter, Karine Narum, David L. Brady, Rebecca A. Little, Stephen F. Burns, Drusilla L. TI Structural and Immunological Analysis of Anthrax Recombinant Protective Antigen Adsorbed to Aluminum Hydroxide Adjuvant SO CLINICAL AND VACCINE IMMUNOLOGY LA English DT Article ID LETHAL TOXIN NEUTRALIZATION; BACILLUS-ANTHRACIS; MONOCLONAL-ANTIBODIES; SALT ADJUVANTS; GUINEA-PIGS; VACCINE; PROTEIN; STABILITY; RECEPTOR; BINDING AB New anthrax vaccines currently under development are based on recombinant protective antigen (rPA) and formulated with aluminum adjuvant. Because long-term stability is a desired characteristic of these vaccines, an understanding of the effects of adsorption to aluminum adjuvants on the structure of rPA is important. Using both biophysical and immunological techniques, we compared the structure and immunogenicity of freshly prepared rPA-Alhydrogel formulations to that of formulations stored for 3 weeks at either room temperature or 37 degrees C in order to assess the changes in rPA structure that might occur upon long-term storage on aluminum adjuvant. Intrinsic fluorescence emission spectra of tryptophan residues indicated that some tertiary structure alterations of rPA occurred during storage on Alhydrogel. Using anti-PA monoclonal antibodies to probe specific regions of the adsorbed rPA molecule, we found that two monoclonal antibodies that recognize epitopes located in domain 1 of PA exhibited greater reactivity to the stored formulations than to freshly prepared formulations. Immunogenicity of rPA-Alhydrogel formulations in mice was assessed by measuring the induction of toxin-neutralizing antibodies, as well as antibodies reactive to 12-mer peptides spanning the length of PA. Mice immunized with freshly prepared formulations developed significantly higher toxin-neutralizing antibody titers than mice immunized with the stored preparations. In contrast, sera from mice immunized with stored preparations exhibited increased reactivity to nine 12-mer peptides corresponding to sequences located throughout the rPA molecule. These results demonstrate that storage of rPA-Alhydrogel formulations can lead to structural alteration of the protein and loss of the ability to elicit toxin-neutralizing antibodies. C1 [Wagner, Leslie; Verma, Anita; Brady, Rebecca A.; Burns, Drusilla L.] US FDA, Ctr Biol Evaluat & Res, Bethesda, MD 20014 USA. [Meade, Bruce D.] Meade Biol, Hillsborough, NC USA. [Reiter, Karine; Narum, David L.] NIAID, Lab Malaria Immunol & Vaccinol, NIH, Rockville, MD USA. [Little, Stephen F.] USA, Med Res Inst Infect Dis, Frederick, MD USA. RP Burns, DL (reprint author), US FDA, Ctr Biol Evaluat & Res, Bethesda, MD 20014 USA. EM drusilla.burns@fda.hhs.gov FU National Institute of Allergy and Infectious Diseases, NIH; Center for Biologics Evaluation and Research, Food and Drug Administration FX This work was supported by the Intramural Research Programs of the National Institute of Allergy and Infectious Diseases, NIH, and the Center for Biologics Evaluation and Research, Food and Drug Administration. The following reagents were obtained from the NIH Biodefense and Emerging Infections Research Resources Repository, NIAID, NIH: anthrax PA, recombinant from B. anthracis, NR-164; anthrax LF, recombinant from B. anthracis, NR-142; J774A. 1 monocyte/macrophage (mouse) working cell bank, NR-28; and rabbit anti-PA reference serum pool, NR-3839. NR 39 TC 17 Z9 17 U1 0 U2 16 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 1556-6811 J9 CLIN VACCINE IMMUNOL JI Clin. Vaccine Immunol. PD SEP PY 2012 VL 19 IS 9 BP 1465 EP 1473 DI 10.1128/CVI.00174-12 PG 9 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 002AX UT WOS:000308503400017 PM 22815152 ER PT J AU Roningen, JM Burbey, TJ AF Roningen, Jeanne M. Burbey, Thomas J. TI Hydrogeologic controls on lake level: a case study at Mountain Lake, Virginia, USA SO HYDROGEOLOGY JOURNAL LA English DT Article DE Groundwater recharge/water budget; Groundwater/surface-water relations; Valley and Ridge Physiographic Province, USA ID RESISTIVITY; WETLANDS; TRANSPIRATION AB Mountain Lake in Giles County, Virginia, USA, has a documented history of severe natural lake-level changes involving groundwater seepage that extends over the past 4,200 years. The natural lake was full during a large part of the twentieth century but dried up completely in September 2008 and levels have yet to recover. The objective of the study was to understand the hydrogeologic factors that influence lake-level changes using a daily water balance, electrical resistivity, water sampling and geochemical analysis, and well logging. Results from the water balance demonstrate the seasonal response to precipitation of a forested first-order drainage system in fractured rock. The resistivity surveys suggest discrete high-permeability areas may provide pathways for lake drainage. Imagery, well logs, and field observations appear to confirm the presence of a fault which crosses the Eastern Continental Divide to the east of the lake that had not previously been discussed in literature on the lake; the position of the lake within local and intermediate groundwater flow systems is considered. Historical data suggest that either significant precipitation or artificial intervention to mitigate seepage would be required for lake-level recovery in the near future. C1 [Roningen, Jeanne M.] US Army Corps Engineers, Cold Reg Res & Engn Lab, Lebanon, NH 03766 USA. [Burbey, Thomas J.] Virginia Polytech Inst & State Univ, Dept Geosci, Blacksburg, VA 24061 USA. RP Roningen, JM (reprint author), US Army Corps Engineers, Cold Reg Res & Engn Lab, 72 Lyme Rd, Lebanon, NH 03766 USA. EM jeanne.m.roningen@usace.army.mil; tjburbey@vt.edu FU Virginia Water Resources Research Center; Geological Society of America FX The authors would like to acknowledge the Virginia Water Resources Research Center and the Geological Society of America for providing funding, the Mountain Lake Hotel and Conservancy for providing access to the study area and assistance with field work, the Mountain Lake Biological Station for weather data and property access, and Stefan Stomulis for access to water level data. We also thank the anonymous reviewers whose comments significantly improved the manuscript. NR 59 TC 0 Z9 0 U1 0 U2 13 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1431-2174 EI 1435-0157 J9 HYDROGEOL J JI Hydrogeol. J. PD SEP PY 2012 VL 20 IS 6 BP 1149 EP 1167 DI 10.1007/s10040-012-0859-x PG 19 WC Geosciences, Multidisciplinary; Water Resources SC Geology; Water Resources GA 001DU UT WOS:000308441100009 ER PT J AU Sundin, J Fear, NT Greenberg, N Riviere, L Herrell, R Adler, A Hoge, C Bliese, P Wessely, S AF Sundin, J. Fear, N. T. Greenberg, N. Riviere, L. Herrell, R. Adler, A. Hoge, C. Bliese, P. Wessely, S. TI A COMPARATIVE ANALYSIS OF DEPLOYMENT ASSOCIATED MENTAL HEALTH ISSUES IN UNITED STATES AND UNITED KINGDOM ARMED FORCES SO JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH LA English DT Meeting Abstract C1 [Sundin, J.; Fear, N. T.; Greenberg, N.] Kings Coll London, ACDMH, London WC2R 2LS, England. [Riviere, L.; Herrell, R.; Hoge, C.; Bliese, P.] Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci, Silver Spring, MD USA. [Wessely, S.] Kings Coll London, Kings Ctr Mil Hlth Res, London WC2R 2LS, England. RI Fear, Nicola/A-1917-2012; Wessely, Simon/A-8713-2008 NR 0 TC 0 Z9 0 U1 0 U2 1 PU BMJ PUBLISHING GROUP PI LONDON PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND SN 0143-005X J9 J EPIDEMIOL COMMUN H JI J. Epidemiol. Community Health PD SEP PY 2012 VL 66 SU 1 BP A8 EP A8 DI 10.1136/jech-2012-201753.020 PG 1 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 007BD UT WOS:000308862900021 ER PT J AU Grujicic, M Pandurangan, B Cheeseman, BA Yen, CF AF Grujicic, M. Pandurangan, B. Cheeseman, B. A. Yen, C-F TI Spall-Fracture Physics and Spallation-Resistance-Based Material Selection SO JOURNAL OF MATERIALS ENGINEERING AND PERFORMANCE LA English DT Article DE material-selection methodology; spall-fracture; spallation resistance AB Spallation is a fracture mode commonly observed in ballistically/blast-wave-loaded structures. The interaction between decompression waves generated within the target structure produces tensile stresses which, if of a sufficient magnitude, may cause material damage and ultimate fracture (spallation). In this study, the phenomenon of spall-fracture is analyzed within a one-dimensional Lagrangian framework. Two distinct analyses are carried out. Within the first analysis, decompression waves are treated as decompression shocks, which simplified the analysis and enabled the formation of spallation-strength-based material index. In the second analysis, decompression waves are treated as smooth (centered simple) waves. This increased the fidelity of the computational analysis, but the material-selection procedure could be done only numerically and an explicit formulation of the spallation-strength-based material-selection index could not be carried out. Overall, the two analyses yielded similar results for the spallation-strength-based material-selection criterion suggesting that the simpler (decompression shock based) one is still adequate for use in the material-selection process. C1 [Grujicic, M.; Pandurangan, B.] Clemson Univ, Dept Mech Engn, Clemson, SC 29634 USA. [Cheeseman, B. A.; Yen, C-F] USA, Res Lab, Survivabil Mat Branch, Aberdeen Proving Ground, MD 21005 USA. RP Grujicic, M (reprint author), Clemson Univ, Dept Mech Engn, 241 Engn Innovat Bldg, Clemson, SC 29634 USA. EM gmica@clemson.edu FU Office of Naval Research (ONR) [4036-CU-ONR-1125]; Pennsylvania State University FX The material presented in this article is based on study supported by the Office of Naval Research (ONR) research contract entitled "Elastomeric Polymer-By-Design to Protect the Warfighter Against Traumatic Brain Injury by Diverting the Blast Induced Shock Waves from the Head", Contract Number 4036-CU-ONR-1125 as funded through the Pennsylvania State University. The authors are indebted to Dr. Roshdy Barsoum of ONR for continuing support and interest in the present work. The authors would also like to thank Dr. Lee Davison whose book "Fundamentals of Shock Wave Propagation in Solids" and specifically Chapter 12: Spall-Fracture, provided the motivation and the necessary shock-physics background used in this study. NR 9 TC 2 Z9 2 U1 0 U2 5 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1059-9495 J9 J MATER ENG PERFORM JI J. Mater. Eng. Perform. PD SEP PY 2012 VL 21 IS 9 BP 1813 EP 1823 DI 10.1007/s11665-011-0068-0 PG 11 WC Materials Science, Multidisciplinary SC Materials Science GA 997SG UT WOS:000308185800001 ER PT J AU Grujicic, M Arakere, G Pandurangan, B Ochterbeck, JM Yen, CF Cheeseman, BA Reynolds, AP Sutton, MA AF Grujicic, M. Arakere, G. Pandurangan, B. Ochterbeck, J. M. Yen, C-F. Cheeseman, B. A. Reynolds, A. P. Sutton, M. A. TI Computational Analysis of Material Flow During Friction Stir Welding of AA5059 Aluminum Alloys SO JOURNAL OF MATERIALS ENGINEERING AND PERFORMANCE LA English DT Article DE friction stir welding; material-flow simulation and analysis; process modeling ID 3-DIMENSIONAL HEAT; 6061-T6 ALUMINUM; PLASTIC-FLOW; VISUALIZATION; MICROSTRUCTURE; SIMULATION; EVOLUTION; JOINTS; MODEL AB Workpiece material flow and stirring/mixing during the friction stir welding (FSW) process are investigated computationally. Within the numerical model of the FSW process, the FSW tool is treated as a Lagrangian component while the workpiece material is treated as an Eulerian component. The employed coupled Eulerian/Lagrangian computational analysis of the welding process was of a two-way thermo-mechanical character (i.e., frictional-sliding/plastic-work dissipation is taken to act as a heat source in the thermal-energy balance equation) while temperature is allowed to affect mechanical aspects of the model through temperature-dependent material properties. The workpiece material (AA5059, solid-solution strengthened and strain-hardened aluminum alloy) is represented using a modified version of the classical Johnson-Cook model (within which the strain-hardening term is augmented to take into account for the effect of dynamic recrystallization) while the FSW tool material (AISI H13 tool steel) is modeled as an isotropic linear-elastic material. Within the analysis, the effects of some of the FSW key process parameters are investigated (e.g., weld pitch, tool tilt-angle, and the tool pin-size). The results pertaining to the material flow during FSW are compared with their experimental counterparts. It is found that, for the most part, experimentally observed material-flow characteristics are reproduced within the current FSW-process model. C1 [Grujicic, M.; Arakere, G.; Pandurangan, B.; Ochterbeck, J. M.] Clemson Univ, Dept Mech Engn, Clemson, SC 29634 USA. [Yen, C-F.; Cheeseman, B. A.] USA, Res Lab, Survivabil Mat Branch, Aberdeen Proving Ground, MD 21005 USA. [Reynolds, A. P.; Sutton, M. A.] Univ S Carolina, Dept Mech Engn, Columbia, SC 29208 USA. RP Grujicic, M (reprint author), Clemson Univ, Dept Mech Engn, 241 Engn Innovat Bldg, Clemson, SC 29634 USA. EM gmica@clemson.edu RI Reynolds, Anthony/F-2585-2010 FU Army Research Office [W911NF-11-1-0207, W911NF-09-1-0513]; U.S. Army/Clemson University [W911NF-04-2-0024, W911NF-06-2-0042] FX The material presented in this paper is based on work supported by two Army Research Office sponsored Grants (W911NF-11-1-0207 and W911NF-09-1-0513) and two U.S. Army/Clemson University Cooperative Agreements (W911NF-04-2-0024 and W911NF-06-2-0042). NR 32 TC 29 Z9 29 U1 6 U2 38 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1059-9495 J9 J MATER ENG PERFORM JI J. Mater. Eng. Perform. PD SEP PY 2012 VL 21 IS 9 BP 1824 EP 1840 DI 10.1007/s11665-011-0069-z PG 17 WC Materials Science, Multidisciplinary SC Materials Science GA 997SG UT WOS:000308185800002 ER PT J AU Xu, K Cresce, AV AF Xu, Kang Cresce, Arthur von Wald TI Li+-solvation/desolvation dictates interphasial processes on graphitic anode in Li ion cells SO JOURNAL OF MATERIALS RESEARCH LA English DT Article ID SOLID-ELECTROLYTE INTERPHASE; PROPYLENE CARBONATE SOLUTIONS; IONIZATION-MASS-SPECTROSCOPY; ORIENTED PYROLYTIC-GRAPHITE; HIGH-PRECISION COULOMETRY; ATOMIC-FORCE MICROSCOPY; SURFACE-FILM FORMATION; LITHIUM-ION; ETHYLENE CARBONATE; GRAPHITE/ELECTROLYTE INTERFACE AB In any electrochemical device, the interface between electrolyte and electrode should be the only "legitimate" location where redox reactions happen. Particularly in Li ion batteries, these interfaces become "interphases" due to the reactivity of the electrode materials used, and they mainly consist of chemical species from the sacrificial decomposition of electrolyte components. Since the emergence of Li ion technology, it has been recognized that interphase on graphitic anodes, usually referred as SEI (solid electrolyte interphase) after its electrolyte attributes, is the key component supporting the reversibility of Li+-intercalation chemistry. Research attention focused on this component during the past two decades has led to substantial understanding about both its chemistry and mechanism. This article summarizes these progresses, and elaborates on the relatively recent insights, including the effect of Li+-solvation sheath structure on the interphasial processes at graphitic anode. A new strategy of forming a more desirable interphase is also discussed. C1 [Xu, Kang; Cresce, Arthur von Wald] USA, Electrochem Branch, Power & Energy Div, Sensor & Elect Devices Directorate,Res Lab, Adelphi, MD 20783 USA. RP Xu, K (reprint author), USA, Electrochem Branch, Power & Energy Div, Sensor & Elect Devices Directorate,Res Lab, Adelphi, MD 20783 USA. EM conrad.k.xu.civ@mail.mil NR 65 TC 35 Z9 35 U1 5 U2 77 PU CAMBRIDGE UNIV PRESS PI NEW YORK PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA SN 0884-2914 J9 J MATER RES JI J. Mater. Res. PD SEP PY 2012 VL 27 IS 18 BP 2327 EP 2341 DI 10.1557/jmr.2012.104 PG 15 WC Materials Science, Multidisciplinary SC Materials Science GA 999RR UT WOS:000308332400001 ER PT J AU Varney, SM Bebarta, VS Pitotti, RL Vargas, TE AF Varney, Shawn M. Bebarta, Vikhyat S. Pitotti, Rebecca L. Vargas, Toni E. TI Survey in the Emergency Department of Parents' Understanding of Cough and Cold Medication Use in Children Younger Than 2 Years SO PEDIATRIC EMERGENCY CARE LA English DT Article DE cough and cold medications; Food and Drug Administration guidelines; Public Health Advisory; infants; over-the-counter ID OVER-THE-COUNTER; PEDIATRIC COUGH AB Objectives: In August 2007, the Food and Drug Administration (FDA) released a public health advisory recommending that over-the-counter cough and cold medications (CCMs) not be used in children younger than 2 years. Our objective was to assess parents' awareness and understanding of the guidelines. Methods: We surveyed caregivers of children younger than 2 years in the emergency department of an urban tertiary care military hospital where civilian patients are also treated. After completing the survey, caregivers received a handout explaining the FDA's recommendations. Results: Our response rate was 99% (264/265). First-time parents constituted 45% (114/251) of responders. Education level was high school, 21%; some college, 36%; and college graduate, 40%. Thirty-one percent (77/247) were aware of the FDA guidelines. Of these 77, 44 (57%) reported the guidelines indicated CCMs were not safe in children younger than 2 years, and 18 (23%) said CCMs have caused death. Twenty-six percent (68/264) did not give CCMs to their children younger than 2 years, and 40% of these reported it was because of learning about the guidelines; 63% (165/264) reported CCMs were effective, 11% ineffective, and 27% did not know. Fifty-seven percent (151/263) reported CCMs were safe, 12% unsafe, and 31% unsure. Twenty-two percent (31/143) planned to use or continue to use CCMs in their children, 34% did not, 23% not sure, and 21% only if their doctor advised it. Conclusions: The majority of caregivers were not aware of the FDA guidelines on CCM use in children younger than 2 years. Most thought CCMs were safe and effective. C1 [Varney, Shawn M.; Bebarta, Vikhyat S.] Brooke Army Med Ctr, Wilford Hall Med Ctr, San Antonio, TX USA. [Varney, Shawn M.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [Bebarta, Vikhyat S.] Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA. [Pitotti, Rebecca L.; Vargas, Toni E.] Wilford Hall USAF Med Ctr, Dept Emergency Med, San Antonio, TX 78236 USA. RP Varney, SM (reprint author), 515 Ruidosa Downs, Helotes, TX 78023 USA. EM smvarney@gmail.com RI bebarta, vikhyat/K-3476-2015 NR 10 TC 4 Z9 4 U1 0 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0749-5161 J9 PEDIATR EMERG CARE JI Pediatr. Emerg. Care PD SEP PY 2012 VL 28 IS 9 BP 883 EP 885 DI 10.1097/PEC.0b013e3182676518 PG 3 WC Emergency Medicine; Pediatrics SC Emergency Medicine; Pediatrics GA 004HZ UT WOS:000308673600011 PM 22929136 ER PT J AU Lachniet, MS Lawson, DE Sloat, AR AF Lachniet, Matthew S. Lawson, Daniel E. Sloat, Alison R. TI Revised C-14 dating of ice wedge growth in interior Alaska (USA) to MIS 2 reveals cold paleoclimate and carbon recycling in ancient permafrost terrain SO QUATERNARY RESEARCH LA English DT Article DE Alaska; Paleoclimate; Radiocarbon dating; Permafrost; Ice wedge; CRREL Permafrost Tunnel ID LATE QUATERNARY LOESS; ISOTOPE COMPOSITION; YUKON-TERRITORY; RADIOCARBON AGE; OXYGEN-ISOTOPE; GROUND ICE; SIBERIA; TUNNEL; CANADA; CHRONOLOGIES AB Establishing firm radiocarbon chronologies for Quaternary permafrost sequences remains a challenge because of the persistence of old carbon in younger deposits. To investigate carbon dynamics and establish ice wedge formation ages in Interior Alaska, we dated a late Pleistocene ice wedge, formerly assigned to Marine Isotope Stage (MIS) 3, and host sediments near Fairbanks, Alaska, with 24 radiocarbon analyses on wood, particulate organic carbon (POC), air-bubble CO2, and dissolved organic carbon (DOC). Our new CO2 and DOC ages are up to 11,170 yr younger than ice wedge POC ages, indicating that POC is detrital in origin. We conclude an ice wedge formation age between 28 and 22 cal ka BP during cold stadial conditions of MIS 2 and solar insolation minimum, possibly associated with Heinrich event 2 or the last glacial maximum. A DOC age for an ice lens in a thaw unconformity above the ice wedge returned a maximum age of 21,470 +/- 200 cal yr BP. Our variable C-14 data indicate recycling of older carbon in ancient permafrost terrain, resulting in radiocarbon ages significantly older than the period of ice-wedge activity. Release of ancient carbon with climatic warming will therefore affect the global C-14 budget (c) 2012 University of Washington. Published by Elsevier Inc. All rights reserved. C1 [Lachniet, Matthew S.; Sloat, Alison R.] Univ Nevada, Las Vegas, NV 89154 USA. [Lawson, Daniel E.] Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. RP Lachniet, MS (reprint author), Univ Nevada, 4505 Maryland Pkwy,Mailstop 4022, Las Vegas, NV 89154 USA. EM Matthew.Lachniet@unlv.edu; Daniel.E.Lawson@usace.army.mil; sloata@unlv.nevada.edu OI Lachniet, Matthew/0000-0001-5250-0144 FU NSF Grants [ARC-0714058, ARC-0714060] FX This research was supported by NSF Grants ARC-0714058 and ARC-0714060. We thank Tim Jull and Alex Leonard at the University of Arizona radiocarbon facility for sample preparation, Prof. D. Lal of Scripps for gracious use of his laboratory, advice and discussion of the CO2 dating technique, and staff of CRREL in Fairbanks, Alaska, for tunnel and cold-room support. We thank Duane Froese, an anonymous reviewer, and the editors (Derek Booth and Lewis Owen) for constructive comments that helped improve the paper. NR 47 TC 9 Z9 9 U1 1 U2 15 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0033-5894 EI 1096-0287 J9 QUATERNARY RES JI Quat. Res. PD SEP PY 2012 VL 78 IS 2 BP 217 EP 225 DI 10.1016/j.yqres.2012.05.007 PG 9 WC Geography, Physical; Geosciences, Multidisciplinary SC Physical Geography; Geology GA 002EY UT WOS:000308516000007 ER PT J AU Athrey, G Barr, KR Lance, RF Leberg, PL AF Athrey, Giridhar Barr, Kelly R. Lance, Richard F. Leberg, Paul L. TI Birds in space and time: genetic changes accompanying anthropogenic habitat fragmentation in the endangered black-capped vireo (Vireo atricapilla) SO EVOLUTIONARY APPLICATIONS LA English DT Article DE anthropogenic fragmentation; bottlenecks; evolutionary dynamics; fragmentation; genetic differentiation; genetic diversity ID EFFECTIVE POPULATION-SIZE; APPROXIMATE BAYESIAN COMPUTATION; GENOTYPING ERRORS; BROOD PARASITISM; LOCAL EXTINCTION; TEMPORAL-CHANGES; N-E; DIVERSITY; CONSERVATION; BOTTLENECKS AB Anthropogenic alterations in the natural environment can be a potent evolutionary force. For species that have specific habitat requirements, habitat loss can result in substantial genetic effects, potentially impeding future adaptability and evolution. The endangered black-capped vireo (Vireo atricapilla) suffered a substantial contraction of breeding habitat and population size during much of the 20th century. In a previous study, we reported significant differentiation between remnant populations, but failed to recover a strong genetic signal of bottlenecks. In this study, we used a combination of historical and contemporary sampling from Oklahoma and Texas to (i) determine whether population structure and genetic diversity have changed over time and (ii) evaluate alternate demographic hypotheses using approximate Bayesian computation (ABC). We found lower genetic diversity and increased differentiation in contemporary samples compared to historical samples, indicating nontrivial impacts of fragmentation. ABC analysis suggests a bottleneck having occurred in the early part of the 20th century, resulting in a magnitude decline in effective population size. Genetic monitoring with temporally spaced samples, such as used in this study, can be highly informative for assessing the genetic impacts of anthropogenic fragmentation on threatened or endangered species, as well as revealing the dynamics of small populations over time. C1 [Athrey, Giridhar; Barr, Kelly R.; Leberg, Paul L.] Univ Louisiana Lafayette, Dept Biol, Lafayette, LA 70504 USA. [Lance, Richard F.] USA, Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS USA. RP Athrey, G (reprint author), Texas A&M Univ, Dept Entomol, 2475 TAMU, College Stn, TX 77843 USA. EM giri.athrey@tamu.edu RI Athrey, Giridhar/H-4077-2011 OI Athrey, Giridhar/0000-0002-7396-5490 FU US Department of Defense under Section 6.1 Basic research program; U.S. Army 6.2 Threatened and Endangered Species program FX We thank the AMNH, New York, NY, MCZ Harvard University, Cambridge, MA, FMNH, Chicago, IL, NMNH, Washington, D. C., and the MVZ, Berkeley, CA, for providing us valuable archival tissue samples that made this study possible. The Natural Resources Branch at Ft. Hood, Kerr Wildlife Management Area, Balcones Canyonlands NWR, Texas Parks and Wildlife Department, Fort Sill Military Reservation and Wichita Mountain Wildlife Refuge provided access to study sites. We thank D. Lindsay, C. Goates, J. Hernandez, S. Pathikonda, L. Butler and S. Leberg for help with field sampling. We thank J. Neigel, S. Mopper, D. Johnson and anonymous reviewers for comments on an earlier version of this manuscript. This study was partly funded by US Department of Defense under Section 6.1 Basic research program and U.S. Army 6.2 Threatened and Endangered Species program to RFL and PLL. NR 79 TC 10 Z9 11 U1 3 U2 52 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1752-4571 J9 EVOL APPL JI Evol. Appl. PD SEP PY 2012 VL 5 IS 6 BP 540 EP 552 DI 10.1111/j.1752-4571.2011.00233.x PG 13 WC Evolutionary Biology SC Evolutionary Biology GA 001MY UT WOS:000308466000002 PM 23028396 ER PT J AU Song, LX Hamilton, JB Moore, AD AF Song, Lixin Hamilton, Jill B. Moore, Angelo D. TI Patient-Healthcare Provider Communication: Perspectives of African American Cancer Patients SO HEALTH PSYCHOLOGY LA English DT Article DE African American; patient-health care provider communication; decision-making; cultural sensitivity; cancer ID PROSTATE-CANCER; BREAST-CANCER; PHYSICIAN COMMUNICATION; RACIAL-DIFFERENCES; PATIENTS PERCEPTIONS; CULTURAL COMPETENCE; OLDER WOMEN; SURVIVAL; VISITS; DISPARITIES AB Objective: African Americans are often viewed as ineffective communicators during medical encounters. However, most previous studies have been conducted among noncancer populations and based on the perceptions of health care providers (HCP) and researchers. This study aimed to explore African American cancer patients' perspectives of HCPs' communication behaviors and how these communication patterns facilitate or hinder their cancer management and survivorship experiences. Methods: This is a secondary data analysis of qualitative interviews with 28 African American cancer patients residing in the Southeastern U.S. Participants were purposefully selected to represent patients of both genders with varied sociodemographic characteristics. Grounded theory techniques of constant comparison were used to identify patterns of responses from the participants. Results: Four major themes were identified about communication patterns between these cancer patients and their HCPs during diagnosis and treatment: (1) communication of cancer information; (2) communication of shared decision making; (3) communication of empathy and understanding; and (4) communication of respect. This study also described the effects of patient-HCP communication (e.g., satisfaction with oncology care, emotional distress, patient loyalty, treatment adherence, decisional regrets). Conclusions: African American cancer patients in this study perceived that HCPs demonstrated different levels of communication sensitivity and skills during cancer diagnosis and treatment. They also believed that HCPs' communication behaviors directly affected their survivorship experiences. Our findings help to gain knowledge of patient-HCP communication and to identify potential strategies for better communication between patients and HCPs among middle-aged and older African American cancer patients, which will ultimately promote culturally sensitive oncology care. C1 [Song, Lixin; Hamilton, Jill B.] Univ N Carolina, Dept Adult & Geriatr Hlth, Sch Nursing, Chapel Hill, NC 27599 USA. [Song, Lixin] Univ N Carolina, Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27599 USA. [Moore, Angelo D.] Tripler Army Med Ctr, Nursing Res Serv, Honolulu, HI 96859 USA. RP Song, LX (reprint author), Univ N Carolina, Dept Adult & Geriatr Hlth, Sch Nursing, Carrington Hall, Chapel Hill, NC 27599 USA. EM lsong@unc.edu NR 46 TC 14 Z9 14 U1 1 U2 20 PU AMER PSYCHOLOGICAL ASSOC PI WASHINGTON PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA SN 0278-6133 J9 HEALTH PSYCHOL JI Health Psychol. PD SEP PY 2012 VL 31 IS 5 BP 539 EP 547 DI 10.1037/a0025334 PG 9 WC Psychology, Clinical; Psychology SC Psychology GA 002CZ UT WOS:000308509900001 PM 21895368 ER PT J AU Warren, RE Osher, SJ Vanderbeek, RG AF Warren, Russell E. Osher, Stanley J. Vanderbeek, Richard G. TI Multiple Aerosol Unmixing by the Split Bregman Algorithm SO IEEE TRANSACTIONS ON GEOSCIENCE AND REMOTE SENSING LA English DT Article DE Aerosols; lidar; L-1-regularization; parameter estimation; remote sensing AB For more than a decade, the U.S. government has been developing laser-based sensors for detecting, locating, and classifying aerosols in the atmosphere at safe standoff ranges. The motivation for this work is the need to discriminate aerosols of biological origin from interferent materials such as smoke and dust using the backscatter from multiple wavelengths in the long wave infrared (LWIR) spectral region. Through previous work, algorithms have been developed for estimating the aerosol spectral dependence and concentration range dependence from these data. The range dependence is required for locating and tracking the aerosol plumes, and the backscatter spectral dependence is used for discrimination by a support vector machine classifier. Substantial progress has been made in these algorithms for the case of a single aerosol present in the lidar line-of-sight (LOS). Often, however, mixtures of aerosols are present along the same LOS overlapped in range and time. Analysis of these mixtures of aerosols presents a difficult inverse problem that cannot be successfully treated by the methods used for single aerosols. Fortunately, recent advances have been made in the analysis of inverse problems using shrinkage-based L-1-regularization techniques. Of the several L-1-regularization methods currently known, the split Bregman algorithm is straightforward to implement, converges rapidly, and is applicable to a broad range of inverse problems including our aerosol unmixing. In this paper, we show how the split Bregman algorithm can successfully resolve LWIR lidar data containing mixtures of bioaerosol simulants and interferents into their separate components. The individual components then can be classified as bio- or nonbioaerosol by our SVM classifier. We illustrate the approach through data collected in field tests over the past several years using the U. S. Army FAL sensor in testing at Dugway Proving Ground, UT. C1 [Warren, Russell E.] EO Stat Inc, Chapel Hill, NC 27517 USA. [Osher, Stanley J.] Univ Calif Los Angeles, Los Angeles, CA 90095 USA. [Vanderbeek, Richard G.] USA, Edgewood Chem Biol Ctr, Aberdeen, MD 21010 USA. RP Warren, RE (reprint author), EO Stat Inc, Chapel Hill, NC 27517 USA. EM eostatinc@aol.com; sjo@math.ucla.edu; richard.vanderbeek@us.army.mil FU U.S. Army RDECOM [W911SR-10-C-0067]; National Science Foundation [DMS0914561] FX This work was supported in part by the U.S. Army RDECOM Contract W911SR-10-C-0067 and in part by National Science Foundation under Grant DMS0914561. NR 10 TC 0 Z9 0 U1 2 U2 7 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0196-2892 J9 IEEE T GEOSCI REMOTE JI IEEE Trans. Geosci. Remote Sensing PD SEP PY 2012 VL 50 IS 9 BP 3271 EP 3279 DI 10.1109/TGRS.2011.2180913 PG 9 WC Geochemistry & Geophysics; Engineering, Electrical & Electronic; Remote Sensing; Imaging Science & Photographic Technology SC Geochemistry & Geophysics; Engineering; Remote Sensing; Imaging Science & Photographic Technology GA 996PY UT WOS:000308105600001 ER PT J AU Xia, F Yang, LT Wang, L Vinel, A AF Xia, Feng Yang, Laurence T. Wang, Lizhe Vinel, Alexey TI Internet of Things SO INTERNATIONAL JOURNAL OF COMMUNICATION SYSTEMS LA English DT Editorial Material C1 [Xia, Feng; Yang, Laurence T.; Wang, Lizhe; Vinel, Alexey] Dalian Univ Technol, Sch Software, Dalian, Peoples R China. Indiana Univ, USA, Indiana, PA USA. Tampere Univ Technol, Tampere, Finland. RP Xia, F (reprint author), Dalian Univ Technol, Sch Software, Dalian, Peoples R China. EM f.xia@ieee.org OI Xia, Feng/0000-0002-8324-1859; Wang, Lizhe/0000-0003-2766-0845 NR 0 TC 67 Z9 67 U1 3 U2 29 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1074-5351 J9 INT J COMMUN SYST JI Int. J. Commun. Syst. PD SEP PY 2012 VL 25 IS 9 SI SI BP 1101 EP 1102 DI 10.1002/dac.2417 PG 2 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA 996JK UT WOS:000308080800001 ER PT J AU Williams, RL Lim, SB Onyuksel, H Marucha, PT AF Williams, Richard L. Lim, Sok Bee Onyuksel, Hayat Marucha, Phillip T. TI Sterically Stabilized Phospholipid Micelles Reduce Activity of a Candidate Antimicrobial Wound Healing Adjunct SO INTERNATIONAL JOURNAL OF PEPTIDE RESEARCH AND THERAPEUTICS LA English DT Article DE Antimicrobial peptide; Wound healing; Drug delivery; Stress ID RESTRAINT-STRESSED MICE; PEG CHAIN-LENGTH; IN-VITRO; POLY(ETHYLENE GLYCOL); DECAPEPTIDE KSL; INFECTION; IRAQ; BACTERIA; SUSCEPTIBILITY; NANOMEDICINE AB KSLW is an antimicrobial decapeptide, presumed to associate with micelles. Linear polymeric chains of hydrophobic phospholipids tend to form micelles, spontaneously, and function as efficient drug-stabilizing delivery systems. Our goal was to examine whether association of a cationic decapeptide with sterically stabilized nanomicelles (SSMs), improves stability and antimicrobial effect in vivo, using an impaired healing model. KSLW solutions were prepared in either saline or 12 mM SSM. Bilateral circular excisional wounds were created on the backs of SKH-1 mice followed by intradermal delivery of peptide solutions. Bacterial assays were conducted to assess bioactivity of KSLW in different formulations. Fluorescence analyses demonstrated an optimum lipid:peptide ratio for loading KSLW in PEGylated phospholipid micelles to be 15:1. Stressed animals treated with KSLW-SSM preparations demonstrated no differences in microbial load at post-operative time points. In vitro assays against Staphylococcus epidermidis confirmed diminished activity of KSLW in SSM solution. The loss of KSLW antimicrobial activity may be based on electrostatic interactions with the anionic surface of SSM, which interfere with the peptide's interaction with bacterial membranes. This study emphasizes the importance of antimicrobial peptide charge, size, and bioactivity, when designing delivery systems for wound healing agents. C1 [Williams, Richard L.] USA, Inst Surg Res DTRD, Ft Sam Houston, TX 78234 USA. [Lim, Sok Bee; Onyuksel, Hayat] Univ Illinois, Coll Pharm, Dept Biopharmaceut Sci, Chicago, IL USA. [Marucha, Phillip T.] Univ Illinois, Coll Dent, Ctr Wound Healing & Tissue Regenerat, Chicago, IL USA. RP Williams, RL (reprint author), USA, Inst Surg Res DTRD, 3650 Chambers Pass,Bldg 3610, Ft Sam Houston, TX 78234 USA. EM richard.williams15@amedd.army.mil FU US Army Medical Research and Materiel Command [W74SHSQZ6160N548] FX The authors are grateful to Dr. Kai Leung and Mr. Johnathan Abercrombie, DTRD, for providing the peptide and performing in vitro microbiology assays, respectively. This study was supported by the US Army Medical Research and Materiel Command, Grant #W74SHSQZ6160N548. NR 51 TC 2 Z9 2 U1 0 U2 6 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1573-3149 J9 INT J PEPT RES THER JI Int. J. Pept. Res. Ther. PD SEP PY 2012 VL 18 IS 3 BP 195 EP 203 DI 10.1007/s10989-012-9292-1 PG 9 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA 002NF UT WOS:000308538200003 ER PT J AU Newell, RA Allore, SM Dowd, OP Netinho, S Asselin, ME AF Newell, Rebecca A. Allore, Suzanne M. Dowd, Ouida P. Netinho, Susan Asselin, Marilyn E. TI Stress among Caregivers of Chronically Ill Older Adults Implications for Nursing Practice SO JOURNAL OF GERONTOLOGICAL NURSING LA English DT Article ID FAMILY CAREGIVERS; ALZHEIMERS-DISEASE; DEMENTIA PATIENTS; DAY-CARE; HEALTH; BURDEN; INTERVENTIONS; SYMPTOMS; STROKE; IMPACT AB Caregiving is a dynamic process involving a series of decisions at different stages of a person's chronic illness trajectory. Research suggests the burdens of caregiving can lead to caregiver stress, the actual or perceived physical or emotional strain experienced by the caregiver. Nurses have a pivotal role in assessing for caregiver stress and providing interventions to assist caregivers. This article defines caregiver stress, discusses the impact that caregiving has on a caregiver, provides assessment principles to identify caregiver stress, and includes evidence-based interventions that can be tailored to individual caregivers to encourage health-promoting behaviors. C1 [Newell, Rebecca A.] Eye Hlth Vision Ctr, N Dartmouth, MA USA. [Newell, Rebecca A.] Home Instead Senior Care, N Dartmouth, MA USA. [Allore, Suzanne M.] USA, Washington, DC USA. [Allore, Suzanne M.] Univ Massachusetts Boston, Boston, MA USA. [Dowd, Ouida P.; Netinho, Susan] St Lukes Hosp, New Bedford, MA USA. [Dowd, Ouida P.; Asselin, Marilyn E.] Univ Massachusetts Dartmouth, Coll Nursing, Dartmouth, NS, Canada. RP Newell, RA (reprint author), Eye Hlth Vision Ctr, N Dartmouth, MA USA. EM rebeccan43@gmail.com NR 52 TC 0 Z9 0 U1 2 U2 15 PU SLACK INC PI THOROFARE PA 6900 GROVE RD, THOROFARE, NJ 08086 USA SN 0098-9134 J9 J GERONTOL NURS JI J. Gerontol. Nurs. PD SEP PY 2012 VL 38 IS 9 BP 18 EP 29 DI 10.3928/00989134-20120807-06 PG 12 WC Geriatrics & Gerontology; Gerontology; Nursing SC Geriatrics & Gerontology; Nursing GA 999XN UT WOS:000308349100004 PM 22897130 ER PT J AU Evans, RK Negus, CH Centi, AJ Spiering, BA Kraemer, WJ Nindl, BC AF Evans, R. K. Negus, C. H. Centi, A. J. Spiering, B. A. Kraemer, W. J. Nindl, B. C. TI Peripheral QCT sector analysis reveals early exercise-induced increases in tibial bone mineral density SO JOURNAL OF MUSCULOSKELETAL & NEURONAL INTERACTIONS LA English DT Article DE pQCT; Exercise; Bone; Early Adaptation; Volumetric Density ID HIGH-IMPACT EXERCISE; CORTICAL BONE; REGIONAL DIFFERENCES; PHYSICAL-ACTIVITY; RANDOMIZED-TRIAL; SHAFT FRACTURE; STRAIN-RATE; MALE RATS; STRENGTH; MASS AB Objectives: The purpose of this controlled trial was to determine whether subtle changes in mineralization and geometry of the tibia were evident following short term exercise interventions. Methods: Fifty-seven female volunteers (age 20.1 +/- 1.6) were randomized to one of four, 13-week training groups: sedentary control, resistance training, aerobic training, or combined aerobic-resistance. A pQCT image analysis software was developed and used to analyze images taken at sites 4%, 38% and 66% from the distal tibia at baseline and at completion of training. Parameters of bone mineral density, geometry and strength were determined for the entire scan cross-section and for each of six 60 degrees polar sectors. Repeated-measures ANOVA and Fisher's LSD post hoc tests analyzed the effects of training over time. Results: Trabecular density (TrDn) at the 4% site increased from 279.8 +/- 37.1 to 283.1 +/- 36.0 mg/cm(3) in the aerobic group, and from 285.1 +/- 24.6 to 287.5 +/- 22.9 mg/cm(3) in the combined group over the study period (P <= 0.001). Regional sector analyses revealed that impact exercises resulted in localized changes to the medial aspect of the tibia. Small increases in total bone area were observed in the diaphysis (38% site) (P<0.05). Conclusions: Subtle, regional increases in trabecular density may be an early measurable manifestation of bone quality changes. C1 [Negus, C. H.] L 3 ATI, Simulat Engn & Testing, San Diego, CA 92121 USA. [Evans, R. K.; Centi, A. J.; Nindl, B. C.] USA, Environm Med Res Inst, Natick, MA 01760 USA. [Spiering, B. A.] Calif State Univ Fullerton, Dept Kinesiol, Fullerton, CA 92634 USA. [Kraemer, W. J.] Univ Connecticut, Storrs, CT USA. RP Negus, CH (reprint author), L 3 ATI, Simulat Engn & Testing, 10770 Wateridge Circle,Suite 200, San Diego, CA 92121 USA. EM Charles.Negus@L-3Com.com FU U.S. Army Medical Research and Materiel Command's Bone Health; Military Medical Readiness Research Program FX This study was funded in part by a grant from the U.S. Army Medical Research and Materiel Command's Bone Health and Military Medical Readiness Research Program. NR 38 TC 8 Z9 8 U1 0 U2 4 PU JMNI PI NAFPLION PA 7 SPILIADOU SQ, NAFPLION, 21 100, GREECE SN 1108-7161 J9 J MUSCULOSKEL NEURON JI J. Musculoskelet. Neuronal Interact. PD SEP PY 2012 VL 12 IS 3 BP 155 EP 164 PG 10 WC Neurosciences; Physiology SC Neurosciences & Neurology; Physiology GA 002UV UT WOS:000308562800005 PM 22947547 ER PT J AU Lang, GM Patrician, P Steele, N AF Lang, Gary Morris Patrician, Patricia Steele, Nancy TI Comparison of Nurse Burnout Across Army Hospital Practice Environments SO JOURNAL OF NURSING SCHOLARSHIP LA English DT Article DE Burnout; military nursing; nurse work environment; nurse outcomes ID AUSTERE ENVIRONMENT; WORK ENVIRONMENTS; JOB-SATISFACTION; CRITICAL-CARE; OUTCOMES; IRAQ; AFGHANISTAN; TRAUMA; HEALTH; IMPACT AB Purpose: The primary purpose of this study was to examine the nursing practice environment and burnout of nursing personnel assigned to a deployed combat support hospital (CSH). A secondary aim was to compare differences in the level of burnout between the deployed Army nursing personnel and Army nursing personnel assigned to an Army hospital in the United States that served as the U.S. military's primary referral center for American combat casualties evacuated from Iraq. Design: A nonexperimental cross-sectional design was used for this study. Methods: The Maslach Burnout Inventory and the Practice Environment Scale were administered to 105 personnel who deployed with a CSH to Iraq. Data from this study were linked to data obtained from 152 nursing personnel who participated in an earlier burnout study at a large Army hospital in the United States. The linked datasets yielded a final sample of 257 Army nursing personnel. Analysis of variance and linear regression analysis were used to analyze these data. Findings: Emotional exhaustion was common across groups. For the deployed nursing personnel, emotional exhaustion was related to a perceived lack of support from management, foundations for quality of care, collegial relationships, and extended work schedules. The U.S.-based Army hospital group scored significantly higher emotional exhaustion, but it was related to the additional responsibilities associated with being an Army nurse, working extended schedules, and working with combat casualties for extended periods of time. The U.S.-based group perceived more personal accomplishment from the work they do. Conclusions: Burnout was common across Army hospital settings. Emotional exhaustion was most problematic in the U.S.-based Army hospital; however, there was less cynicism toward patients and a greater perception of personal accomplishment associated with work. Clinical Relevance: This study supports the importance of a professional practice environment for Army nursing personnel both during deployment and in U.S.-based Army hospitals. Journal of Nursing Scholarship, 2011; XX:X, XXXXXX. (c) 2011 Sigma Theta Tau International. C1 [Lang, Gary Morris] USA, Task Force Med Afghanistan Bagram, Med Brigade 1, APO, AE 09354 USA. [Patrician, Patricia] Univ Alabama Birmingham, Sch Nursing, Birmingham, AL USA. [Steele, Nancy] Womack Army Med Ctr, Ctr Nurse Sci & Clin Inquiry, Ft Bragg, NC USA. RP Lang, GM (reprint author), USA, Task Force Med Afghanistan Bagram, Med Brigade 1, APO, AE 09354 USA. EM glang002@yahoo.com NR 36 TC 3 Z9 3 U1 1 U2 18 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1527-6546 J9 J NURS SCHOLARSHIP JI J. Nurs. Scholarsh. PD SEP PY 2012 VL 44 IS 3 BP 274 EP 283 DI 10.1111/j.1547-5069.2012.01462.x PG 10 WC Nursing SC Nursing GA 998AD UT WOS:000308208700010 PM 22882620 ER PT J AU Zakharova, NT Videen, G Khlebtsov, NG AF Zakharova, Nadezhda T. Videen, Gorden Khlebtsov, Nikolai G. TI Comprehensive T-matrix reference database: A 2009-2011 update SO JOURNAL OF QUANTITATIVE SPECTROSCOPY & RADIATIVE TRANSFER LA English DT Article DE Electromagnetic scattering; T-matrix method; Nonspherical particles; Many-particle aggregates ID LIGHT ABSORBING CARBON; DISCRETE DIPOLE APPROXIMATION; LORENZ-MIE THEORY; OPTICAL-PROPERTIES; ELECTROMAGNETIC SCATTERING; NONSPHERICAL PARTICLES; METAL NANOPARTICLES; FAR-FIELD; RADIATIVE PROPERTIES; MULTIPLE-SCATTERING AB The T-matrix method is one of the most versatile and efficient theoretical techniques widely used for the computation of electromagnetic scattering by single and composite particles, discrete random media, and particles in the vicinity of an interface separating two half-spaces with different refractive indices. This paper presents an update to the comprehensive database of peer-reviewed T-matrix publications compiled by us previously and includes the publications that appeared since 2009. It also lists several earlier publications not included in the original database. (C) 2012 Elsevier Ltd. All rights reserved. C1 [Zakharova, Nadezhda T.] NASA, Trinnovim, Goddard Inst Space Studies, New York, NY 10025 USA. [Videen, Gorden] USA, Res Lab, AMSRL IS EE, Adelphi, MD 20783 USA. [Khlebtsov, Nikolai G.] Russian Acad Sci, Inst Biochem & Physiol Plants & Microorganisms, Saratov 410015, Russia. RP Zakharova, NT (reprint author), NASA, Trinnovim, Goddard Inst Space Studies, 2880 Broadway, New York, NY 10025 USA. EM nadezhda.zakharova@nasa.gov RI Khlebtsov, Nikolai/D-6199-2017; Pylaev, Timofey/A-8401-2016; OI Pylaev, Timofey/0000-0002-2701-3333; Khlebtsov, Nikolai/0000-0002-2055-7784 FU NASA FX We thank Josefina Mora and Zoe Wai for helping to obtain copies of publications that were not readily accessible. This project was sponsored by NASA. NR 294 TC 13 Z9 13 U1 1 U2 33 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0022-4073 EI 1879-1352 J9 J QUANT SPECTROSC RA JI J. Quant. Spectrosc. Radiat. Transf. PD SEP PY 2012 VL 113 IS 14 BP 1844 EP 1852 DI 10.1016/j.jqsrt.2012.04.009 PG 9 WC Optics; Spectroscopy SC Optics; Spectroscopy GA 976VN UT WOS:000306615400008 ER PT J AU Natesan, S Baer, DG Zamora, DO Wrice, NL Becerra, SC Christy, RJ AF Natesan, S. Baer, D. G. Zamora, D. O. Wrice, N. L. Becerra, S. C. Christy, R. J. TI Development of a vascularized skin construct using adipose derived stem cells from debrided burn skin SO JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE LA English DT Meeting Abstract C1 [Natesan, S.; Baer, D. G.; Zamora, D. O.; Wrice, N. L.; Becerra, S. C.; Christy, R. J.] USA, Inst Surg Res, Washington, DC USA. RI Zamora, David/B-9889-2011 NR 0 TC 0 Z9 0 U1 0 U2 1 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1932-6254 J9 J TISSUE ENG REGEN M JI J. Tissue Eng. Regen. Med. PD SEP PY 2012 VL 6 SU 1 SI SI BP 91 EP 91 PG 1 WC Cell & Tissue Engineering; Biotechnology & Applied Microbiology; Cell Biology; Engineering, Biomedical SC Cell Biology; Biotechnology & Applied Microbiology; Engineering GA 999LG UT WOS:000308313000329 ER PT J AU Corona, BT Wu, X Walters, TJ AF Corona, B. T. Wu, X. Walters, T. J. TI Treatment of volumetric muscle loss injury with muscle-derived ECM and BMSCs promotes functional recovery in rat tibialis anterior muscle SO JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE LA English DT Meeting Abstract C1 [Corona, B. T.; Wu, X.; Walters, T. J.] USA, Inst Surg Res, Washington, DC USA. NR 0 TC 0 Z9 0 U1 0 U2 4 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1932-6254 J9 J TISSUE ENG REGEN M JI J. Tissue Eng. Regen. Med. PD SEP PY 2012 VL 6 SU 1 SI SI BP 117 EP 117 PG 1 WC Cell & Tissue Engineering; Biotechnology & Applied Microbiology; Cell Biology; Engineering, Biomedical SC Cell Biology; Biotechnology & Applied Microbiology; Engineering GA 999LG UT WOS:000308313001024 ER PT J AU Zamora, DO Natesan, S Suggs, LG Christy, RJ AF Zamora, D. O. Natesan, S. Suggs, L. G. Christy, R. J. TI Development of a novel plasma hydrogels for use as a cell delivery scaffold SO JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE LA English DT Meeting Abstract C1 USA, Inst Surg Res, Houston, TX USA. Univ Texas Austin, Austin, TX 78712 USA. RI Zamora, David/B-9889-2011 NR 0 TC 0 Z9 0 U1 0 U2 4 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1932-6254 J9 J TISSUE ENG REGEN M JI J. Tissue Eng. Regen. Med. PD SEP PY 2012 VL 6 SU 1 SI SI BP 160 EP 160 PG 1 WC Cell & Tissue Engineering; Biotechnology & Applied Microbiology; Cell Biology; Engineering, Biomedical SC Cell Biology; Biotechnology & Applied Microbiology; Engineering GA 999LG UT WOS:000308313001189 ER PT J AU Baer, BPRB Lien, W Hale, R AF Baer, B. P. R. Brown Lien, W. Hale, R. TI Clinical modeling for lateral mandibular body reconstruction: initial results from a pig mandible model SO JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE LA English DT Meeting Abstract C1 [Baer, B. P. R. Brown; Lien, W.; Hale, R.] USA, Inst Surg Res, Washington, DC USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1932-6254 J9 J TISSUE ENG REGEN M JI J. Tissue Eng. Regen. Med. PD SEP PY 2012 VL 6 SU 1 SI SI BP 398 EP 398 PG 1 WC Cell & Tissue Engineering; Biotechnology & Applied Microbiology; Cell Biology; Engineering, Biomedical SC Cell Biology; Biotechnology & Applied Microbiology; Engineering GA 999LG UT WOS:000308313003271 ER PT J AU Gruber, JB Vetter, U Burdick, GW Fleischman, ZD Merkle, LD Taniguchi, T Yuan, XL Sekiguchi, T Jurgens, D Hofsass, H AF Gruber, John B. Vetter, Ulrich Burdick, Gary W. Fleischman, Zackery D. Merkle, Larry D. Taniguchi, Takashi Yuan Xiaoli Sekiguchi, Takashi Juergens, Daniel Hofsaess, Hans TI Analysis of the spectra of trivalent erbium in multiple sites of hexagonal aluminum nitride SO OPTICAL MATERIALS EXPRESS LA English DT Article ID ENERGY-LEVELS; HIGH-PRESSURE; SINGLE; GAN; LANTHANIDES; CERAMICS; ALN AB The 12 K cathodoluminescence spectra of Er3+ doped into single crystals of aluminum nitride (2H-AlN) in the hexagonal phase are reported between 320 nm and 775 nm. The emission spectra represent transitions from the lower Stark level of P-2(3/2) to the Stark levels of the I-4(15/2), I-4(13/2), I-4(11/2), I-4(9/2), F-4(9/2), and S-4(3/2) multiplet manifolds of Er3+(4f(11)). Emission spectra from S-4(3/2) to I-4(15/2) are also reported. All observed strong line emission are accounted for in terms of two principle sites, denoted site "a" and site "b", with a few line spectra attributed to additional sites. A parameterized Hamiltonian that includes the atomic and crystal-field terms for Er3+(4f(11))(2S+1) L-J was used to determine the symmetry and the crystal field splitting of the "a" and "b" sites. A descent in symmetry calculation was carried out to determine if distortion due to the size difference between Er, Al and the vacancies can be discerned. Modeling results assuming C-3v and C-1h are discussed. It appears that the sensitivity to a C-1h model is not sufficient to invalidate the choice of C-3v as an approximate symmetry for both sites. The g-factors reported from an EPR study of Er3+ in single-crystal AlN are in reasonable agreement with calculated g-factors for Er3+ in the "a" site assuming C-3v symmetry. (C) 2012 Optical Society of America C1 [Gruber, John B.] Univ Texas San Antonio, Dept Phys & Astron, San Antonio, TX 78249 USA. [Vetter, Ulrich; Juergens, Daniel; Hofsaess, Hans] Univ Gottingen, Inst Phys 2, D-37077 Gottingen, Germany. [Burdick, Gary W.] Andrews Univ, Dept Phys, Berrien Springs, MI 49104 USA. [Fleischman, Zackery D.; Merkle, Larry D.] USA, Res Lab, RDRL SEE M, Adelphi, MD 20783 USA. [Taniguchi, Takashi; Yuan Xiaoli; Sekiguchi, Takashi] Natl Inst Mat Sci, Tsukuba, Ibaraki 3050044, Japan. RP Gruber, JB (reprint author), Univ Texas San Antonio, Dept Phys & Astron, San Antonio, TX 78249 USA. EM uvetter@uni-goettingen.de RI Burdick, Gary/D-3233-2013; takashi, Sekiguchi/D-2603-2010; TANIGUCHI, Takashi/H-2718-2011 OI Burdick, Gary/0000-0002-8066-5330; NR 32 TC 2 Z9 2 U1 0 U2 35 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 2159-3930 J9 OPT MATER EXPRESS JI Opt. Mater. Express PD SEP 1 PY 2012 VL 2 IS 9 BP 1186 EP 1202 PG 17 WC Materials Science, Multidisciplinary; Optics SC Materials Science; Optics GA 003GW UT WOS:000308598300002 ER PT J AU Mulligan, CP Papi, PA Gall, D AF Mulligan, C. P. Papi, P. A. Gall, D. TI Ag transport in CrN-Ag nanocomposite coatings SO THIN SOLID FILMS LA English DT Article DE Chromium nitride; Silver; Lubrication; Sputtering; Solid lubrication; Adaptive lubrication ID SELF-LUBRICATING COATINGS; TRIBOLOGICAL COATINGS; COMPOSITE COATINGS; TEMPERATURE; GROWTH; SILVER; DIFFUSION; FILMS; MICROSTRUCTURE; DEPOSITION AB 2-mu m-thick CrN-Ag composite coatings containing 22 at.% Ag were deposited on Si(001) by reactive co-sputtering at T-s = 300, 400, and 500 degrees C. Subsequent vacuum annealing at T-a = 425, 525, and 625 degrees C causes Ag transport to the surface. Auger electron spectroscopy and plan-view microscopy are used to quantify the Ag transport to the surface, which increases strongly with increasing Delta T = T-a - T-s. Compositional depth profiles and cross-sectional microscopy show that annealing causes a negligible Ag gradient through the composite layer, suggesting that the Ag transport is detachment-limited as opposed to diffusion-limited. Statistical analyses of Ag aggregate size-distributions within the matrix show that large aggregates (>= 50 nm) are unaffected by annealing, while the Ag in a large fraction of small aggregates (<50 nm) moves to the surface, leaving behind 10-50 nm wide voids in the annealed composite. This indicates that the Ag from the smaller grains, with a higher chemical potential and thus a higher detachment rate, is transferred to the large grains on the surface which are 200-1000 nm wide. (C) 2012 Elsevier B. V. All rights reserved. C1 [Mulligan, C. P.; Papi, P. A.; Gall, D.] Rensselaer Polytech Inst, Dept Mat Sci & Engn, Troy, NY 12180 USA. [Mulligan, C. P.] USA, Armament Res Dev & Engn Ctr, Benet Labs, Watervliet, NY 12189 USA. RP Gall, D (reprint author), Rensselaer Polytech Inst, Dept Mat Sci & Engn, Troy, NY 12180 USA. EM galld@rpi.edu RI Gall, Daniel/B-1060-2008 OI Gall, Daniel/0000-0002-5762-9307 FU Armament Research, Development and Engineering Center; National Science Foundation [0645312, 1031201] FX This research was supported by the Armament Research, Development and Engineering Center, and by the National Science Foundation under grant nos. 0645312 and 1031201. The authors thank David Frey of Rensselaer Polytechnic Institute for FIB cross-section preparation and imaging and Prof. Thierry Blanchet of Rensselaer Polytechnic Institute for many valuable discussions during the preparation of this manuscript. NR 37 TC 13 Z9 14 U1 3 U2 30 PU ELSEVIER SCIENCE SA PI LAUSANNE PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND SN 0040-6090 J9 THIN SOLID FILMS JI Thin Solid Films PD SEP 1 PY 2012 VL 520 IS 22 BP 6774 EP 6779 DI 10.1016/j.tsf.2012.06.082 PG 6 WC Materials Science, Multidisciplinary; Materials Science, Coatings & Films; Physics, Applied; Physics, Condensed Matter SC Materials Science; Physics GA 997YW UT WOS:000308205400010 ER PT J AU Parida, BK Cap, AP McFaul, SJ AF Parida, B. K. Cap, A. P. McFaul, S. J. TI Centrifugation Effects on Plasma Microparticle Populations SO TRANSFUSION LA English DT Meeting Abstract CT AABB Annual Meeting and CTTXPO CY OCT 06-09, 2012 CL Boston, MA SP AABB, CTTXPO C1 [Parida, B. K.; Cap, A. P.; McFaul, S. J.] USA, Inst Surg Res, San Antonio, TX USA. EM bijaya.parida.ctr@us.army.mil NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0041-1132 J9 TRANSFUSION JI Transfusion PD SEP PY 2012 VL 52 SU 3 SI SI BP 56A EP 56A PG 1 WC Hematology SC Hematology GA 000PH UT WOS:000308398600115 ER PT J AU Stanton, RS Yogi, YN Minamoto, M Takenaka, K Blomberg, F AF Stanton, R. S. Yogi, Y. N. Minamoto, M. Takenaka, K. Blomberg, F. TI An Example of Passively Acquired Anti-C And/Or Anti-G From Rh Immune Globulin Found to Be Present in an Eluate Due to the Matuhasi-Ogata Phenomenon SO TRANSFUSION LA English DT Meeting Abstract CT AABB Annual Meeting and CTTXPO CY OCT 06-09, 2012 CL Boston, MA SP AABB, CTTXPO C1 [Stanton, R. S.; Yogi, Y. N.; Minamoto, M.; Takenaka, K.; Blomberg, F.] Tripler Army Med Ctr, Blood Bank, Honolulu, HI 96859 USA. EM rostst@aol.com NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0041-1132 J9 TRANSFUSION JI Transfusion PD SEP PY 2012 VL 52 SU 3 SI SI BP 152A EP 152A PG 1 WC Hematology SC Hematology GA 000PH UT WOS:000308398600365 ER PT J AU Walsh, MR Walsh, ME Ramsey, CA AF Walsh, Michael R. Walsh, Marianne E. Ramsey, Charles A. TI Measuring Energetic Contaminant Deposition Rates on Snow SO WATER AIR AND SOIL POLLUTION LA English DT Article DE Residues; Explosives; Propellants; Quantification; Snow surface; Ice ID SALT-MARSH; LIVE-FIRE; RESIDUES; RANGES; DETONATIONS AB Energetic residues from military live-fire training will accumulate on ranges and lead to the contamination of soil and water. Characterizing surface soils for energetic contamination has been conducted extensively in the past. However, deriving mass deposition rates on soils for specific munition-related activities, necessary for determining the cumulative impact of these activities and developing range sustainability models, has been problematic. Factors include determining the energetic residues deposition area, discriminating current deposition from previous activities, separating the residues from the collection matrix, and processing the samples. To circumvent these problems, methods were developed for sampling energetic residues on clean snow surfaces. At firing points, a clean snow surface allows the collection of propellant residues from a known quantity and type of munition. Explosives residues from projectile detonations can be sampled from clean snow- and ice-covered surfaces in active impact areas. Sampling protocols have been optimized and quality assurance procedures have been developed during years of research on munition residues deposition rates. These methods are currently being used in the US, Canada, and Norway for both energetics and metal contaminants with other applications under consideration. This paper describes the current sampling protocol for clean snow surfaces and presents examples of its application. C1 [Walsh, Michael R.; Walsh, Marianne E.] USA, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. [Ramsey, Charles A.] Envirostat INC, Ft Collins, CO 80522 USA. RP Walsh, MR (reprint author), USA, Cold Reg Res & Engn Lab, 72 Lyme Rd, Hanover, NH 03755 USA. EM Michael.Walsh@usace.army.mil; Marianne.E.Walsh@usace.army.mil; Chuck@Envirostat.org FU Strategic Environmental Research and Development Program; Alaska Soil and Water Monitoring Fund; US Army Environmental Command FX Funding for this work was provided by the Strategic Environmental Research and Development Program, Dr. Jeffrey Marquesse, Executive Director, and Dr. Andrea Leeson, Environmental Restoration Program manager; the Alaska Soil and Water Monitoring Fund, Gary Larson, Director; and the US Army Environmental Command under various projects funded by Dr. Bonnie Packer. Valuable assistance was also provided by the US Army Alaska and the US Army Garrison Alaska. Funding and assistance were provided without direct influence on the research or conclusions. NR 25 TC 5 Z9 5 U1 1 U2 5 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0049-6979 J9 WATER AIR SOIL POLL JI Water Air Soil Pollut. PD SEP PY 2012 VL 223 IS 7 BP 3689 EP 3699 DI 10.1007/s11270-012-1141-5 PG 11 WC Environmental Sciences; Meteorology & Atmospheric Sciences; Water Resources SC Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences; Water Resources GA 985OO UT WOS:000307276400010 ER PT J AU Chen, IR Bao, FY Chang, MJ Cho, JH AF Chen, Ing-Ray Bao, Fenye Chang, MoonJeong Cho, Jin-Hee TI Integrated Social and QoS Trust-Based Routing in Delay Tolerant Networks SO WIRELESS PERSONAL COMMUNICATIONS LA English DT Article DE Delay tolerant networks; Opportunistic routing; Trust management; Trust-based routing; Social networks; Resiliency; Performance analysis; Stochastic Petri nets ID DTNS AB We propose and analyze a class of integrated social and quality of service (QoS) trust-based routing protocols in mobile ad-hoc delay tolerant networks. The underlying idea is to incorporate trust evaluation in the routing protocol, considering not only QoS trust properties but also social trust properties to evaluate other nodes encountered. We prove that our protocol is resilient against bad-mouthing, good-mouthing and whitewashing attacks performed by malicious nodes. By utilizing a stochastic Petri net model describing a delay tolerant network consisting of heterogeneous mobile nodes with vastly different social and networking behaviors, we analyze the performance characteristics of trust-based routing protocols in terms of message delivery ratio, message delay, and message overhead against connectivity-based, epidemic and PROPHET routing protocols. The results indicate that our trust-based routing protocols outperform PROPHET and can approach the ideal performance obtainable by epidemic routing in delivery ratio and message delay, without incurring high message overhead. Further, integrated social and QoS trust-based protocols can effectively trade off message delay for a significant gain in message delivery ratio and message overhead over traditional connectivity-based routing protocols. C1 [Chen, Ing-Ray; Bao, Fenye; Chang, MoonJeong] Virginia Tech, Dept Comp Sci, Blacksburg, VA 24061 USA. [Cho, Jin-Hee] USA, Computat & Informat Sci Directorate, Res Lab, Adelphi, MD USA. RP Chen, IR (reprint author), Virginia Tech, Dept Comp Sci, Blacksburg, VA 24061 USA. EM irchen@vt.edu; baofenye@vt.edu; mjchang@vt.edu; jinhee.cho@us.army.mil FU Office of Naval Research [N00014-10-1-0156]; National Research Foundation of Korea; Korean Government [NRF-2009-352-D00262] FX This work was supported in part by the Office of Naval Research under Grant N00014-10-1-0156. This work was supported by the National Research Foundation of Korea Grant funded by the Korean Government [NRF-2009-352-D00262] to Dr. Chang. NR 20 TC 5 Z9 5 U1 0 U2 15 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0929-6212 EI 1572-834X J9 WIRELESS PERS COMMUN JI Wirel. Pers. Commun. PD SEP PY 2012 VL 66 IS 2 BP 443 EP 459 DI 10.1007/s11277-011-0351-2 PG 17 WC Telecommunications SC Telecommunications GA 992EF UT WOS:000307757700014 ER PT J AU Pallis, M Cameron, KL Svoboda, SJ Owens, BD AF Pallis, Mark Cameron, Kenneth L. Svoboda, Steven J. Owens, Brett D. TI Epidemiology of Acromioclavicular Joint Injury in Young Athletes SO AMERICAN JOURNAL OF SPORTS MEDICINE LA English DT Article DE acromioclavicular; sprain; epidemiology; risk factor ID SHOULDER INJURIES AB Background: Acromioclavicular (AC) joint injuries, particularly sprains, are common in athletic populations and may result in significant time lost to injury. However, surprisingly, little is known of the epidemiology of this injury. Purpose: To define the incidence of AC joint injuries and to determine the risk factors for injury. Study Design: Descriptive epidemiological study. Methods: A longitudinal cohort study was performed to determine the incidence and characteristics of AC joint injury at the United States Military Academy between 2005 and 2009. All suspected AC joint injuries were reviewed by an independent orthopaedic surgeon using both chart reviews as well as assessments of radiological imaging studies. Injuries were graded according to the modified Rockwood classification system as well as dichotomized into low-grade (Rockwood types I and II) and high-grade (Rockwood types III, IV, V, and VI) injuries for analysis. Injury mechanisms, return-to-play timing, and athlete-exposures were documented and analyzed. chi(2) and Poisson regression analyses were performed, with statistical significance set at P < .05. Results: During the study period, 162 new AC joint injuries and 17,606 person-years at risk were documented, for an overall incidence rate of 9.2 per 1000 person-years. The majority of the AC joint injuries were low-grade (145 sprains, 89%) injuries, with 17 high-grade injuries. Overall, male patients experienced a significantly higher incidence rate for AC joint injuries than female patients (incidence rate ratio [IRR], 2.18; 95% confidence interval [CI], 1.21-4.31). An AC joint injury occurred most commonly during athletics (91%). The incidence rate of AC joint injury was significantly higher in intercollegiate athletes than intramural athletics when using athlete-exposure as a measure of person-time at risk (IRR, 2.11; 95% CI, 1.31-3.56). Similarly, the incidence rate of AC injury was significantly higher among male intercollegiate athletes when compared to female athletes (IRR, 3.56; 95% CI, 1.74-8.49) when using athlete-exposure as the denominator. The intercollegiate sports of men's rugby, wrestling, and hockey had the highest incidence rate of AC joint injury. Acromioclavicular injuries resulted in at least 1359 total days lost to injury and an average of 18.4 days lost per athlete. The average time lost to injury for low-grade sprains was 10.4 days compared with high-grade injuries at 63.7 days. Of the patients with high-grade injuries, 71% elected to undergo coracoclavicular/AC reconstructions. The rate of surgical intervention was 19 times higher for high-grade AC joint injuries than for low-grade injuries (IRR, 19.2; 95% CI, 7.64-48.23; P < .0001). Conclusion: Acromioclavicular separations are relatively common in young athletes. Most injuries occur during contact sports such as rugby, wrestling, and hockey. Male athletes are at greater risk than female athletes. Intercollegiate athletes are at greater risk than intramural athletes. The average time lost to sport due to AC joint injury was 18 days, with low-grade injuries averaging 10 days lost. High-grade injuries averaged 64 days lost to sport, and 71% elected to undergo surgical repair/reconstruction. C1 [Pallis, Mark; Cameron, Kenneth L.; Svoboda, Steven J.; Owens, Brett D.] US Mil Acad, Keller Army Hosp, West Point, NY 10996 USA. RP Owens, BD (reprint author), US Mil Acad, Keller Army Hosp, 900 Washington Rd, West Point, NY 10996 USA. EM b.owens@us.army.mil OI Cameron, Kenneth/0000-0002-6276-4482 NR 10 TC 28 Z9 29 U1 2 U2 18 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0363-5465 J9 AM J SPORT MED JI Am. J. Sports Med. PD SEP PY 2012 VL 40 IS 9 BP 2072 EP 2077 DI 10.1177/0363546512450162 PG 6 WC Orthopedics; Sport Sciences SC Orthopedics; Sport Sciences GA 998IH UT WOS:000308230600024 PM 22707749 ER PT J AU Grammer, GL Slack, WT Peterson, MS Dugo, MA AF Grammer, Gretchen L. Slack, William T. Peterson, Mark S. Dugo, Mark A. TI Nile tilapia Oreochromis niloticus (Linnaeus, 1758) establishment in temperate Mississippi, USA: multi-year survival confirmed by otolith ages SO AQUATIC INVASIONS LA English DT Article DE Cichlidae; aquaculture; non-native; validation; tilapia ID BLUEGILL LEPOMIS-MACROCHIRUS; ETHIOPIAN RIFT-VALLEY; MAN-MADE LAKES; CLIMATE-CHANGE; HERICHTHYS-CYANOGUTTATUS; COASTAL MISSISSIPPI; FISH OTOLITHS; GROWTH; L.; REPRODUCTION AB Tolerance and adaptability to changing environmental parameters have made Nile tilapia Oreochromis niloticus (Linnaeus, 1758) a hardy and desirable aquaculture species. These traits have also enabled this fish to become a highly successful invasive species into temperate and subtropical aquatic environments. Otolith-based ages of Nile tilapia (41.3 - 400.0 mm TL, 1.34 - 1,293 g WW, n = 259) collected from a power plant cooling reservoir and the Pascagoula River proper indicated that feral populations overwintered reaching ages up to 4+ years old in coastal Mississippi, USA; these data confirm their establishment. A survey of mean daily winter (December - February) water temperatures from 2004 - 2010 in this region showed minimum lethal temperatures of < 10 degrees C to occur nearly 11% of the time attesting to the adaptability of the Nile tilapia as an invasive species. One annulus (opaque zone) per year was being deposited from April to August based on marginal increment analysis along with sulcal groove length-age estimation of the young-of-the-year Nile tilapia. Additionally, life history metrics measured for this temperate population of Nile tilapia were nearly identical to those reported from African environments, indicating they are flourishing in this non-native habitat. C1 [Grammer, Gretchen L.] Univ Adelaide, Sch Earth & Environm Sci, Adelaide, SA 5005, Australia. [Slack, William T.] USA, Engineer Res & Dev Ctr, Waterways Expt Stn EE A, Vicksburg, MS 39180 USA. [Peterson, Mark S.] Univ So Mississippi, Dept Coastal Sci, Ocean Springs, MS 39564 USA. [Dugo, Mark A.] Jackson State Univ, Environm Sci Program, Jackson, MS 39217 USA. RP Grammer, GL (reprint author), Univ Adelaide, Sch Earth & Environm Sci, Darling Bldg DP 418, Adelaide, SA 5005, Australia. EM gretchen.grammer@adelaide.edu.au; todd.slack@usace.army.mil; mark.peterson@usm.edu; mark.a.dugo@students.jsums.edu OI Grammer, Gretchen/0000-0003-1605-8007 FU U.S. Fish and Wildlife Service State Wildlife Grant Program (Mississippi ); Mississippi Department of Wildlife, Fisheries, and Parks FX We thank the Jackson County Port Authority for access to the Plant Daniels Cooling Reservoir, and appreciate the hospitality given by B. Hoard and J. Reynolds. Field assistance was provided by B. Fedrick, B. Lezina, J. McDonald, S. Peyton, L. Turner, M. Wilson and C. Wright, and B. Comyns provided guidance during otolith preparation and aging. This project was funded in part through a U.S. Fish and Wildlife Service State Wildlife Grant Program (Mississippi SWG 02) through a cooperative agreement with the Mississippi Department of Wildlife, Fisheries, and Parks. Permission was granted by the Chief of Engineers to publish this information. The experiments performed in this study comply with the current laws of the country in which the experiments were carried out. NR 43 TC 14 Z9 15 U1 0 U2 21 PU REGIONAL EURO-ASIAN BIOLOGICAL INVASIONS CENTRE-REABIC PI HELSINKI PA PL 3, HELSINKI, 00981, FINLAND SN 1798-6540 J9 AQUAT INVASIONS JI Aquat. Invasions PD SEP PY 2012 VL 7 IS 3 BP 367 EP 376 DI 10.3391/ai.2012.7.3.008 PG 10 WC Ecology; Marine & Freshwater Biology SC Environmental Sciences & Ecology; Marine & Freshwater Biology GA 999YS UT WOS:000308352500008 ER PT J AU Gaydos, SJ AF Gaydos, Steven John TI Low Back Pain: Considerations for Rotary-Wing Aircrew SO AVIATION SPACE AND ENVIRONMENTAL MEDICINE LA English DT Review DE backache; low back pain; aircrew disability; helicopter; rotary wing ID WHOLE-BODY VIBRATION; HELICOPTER PILOTS; EXERCISE THERAPY; IN-FLIGHT; NECK PAIN; POSTURE; PREVALENCE; DISORDERS; AVIATORS; EXPOSURE AB GAYDOS SJ. Low back pain: considerations for rotary-wing aircrew. Aviat Space Environ Med 2012; 83:879-89. Low back pain remains a significant issue among helicopter aircrew. There is a considerable body of scientific literature devoted to the problem, including epidemiologic and experimental studies addressing prevalence, characteristics, primary etiology, and contributing factors. It is endemic and multinational, with a prevalence ranging from 50-92%. Archetypal pain begins with flight or within hours of flight, is mostly targeted in the low back/lumbar region and/or buttocks, is transient, and is commonly described as dull and achy. A minority develop chronic, persistent pain that is variously described with dissimilar characteristics. The pernicious effects of back pain or discomfort while piloting may affect flight performance and safety, including reduced operational effectiveness and lost duty time, occupational attrition, curtailed or cancelled missions, compromised emergency egress, and performance deficits during critical phases of flight. The majority of etiologic studies have focused on the pathophysical posture adopted by pilots for aircraft control and exposure to whole body vibration. With more evidence for the former, it remains likely that both, as well as other factors, may have a contributory and perhaps integrative or concerted role. Corrective and mitigation strategies have addressed lumbar support, seat and cockpit ergonomic redesign, and improved aircrew health. Flight surgeons should be familiar with this prevalent issue and future research must address longitudinal cohort studies with clear definitions, relevant and valid exposure data, dose-response detail, and control for contributing factors and confounders. C1 [Gaydos, Steven John] USA, Aviat Ctr, Headquarters Army Air Corps, Stockbridge SO208DY, Hants, England. [Gaydos, Steven John] USA, Aeromed Res Lab, Ft Rucker, AL USA. RP Gaydos, SJ (reprint author), USA, Aviat Ctr, Headquarters Army Air Corps, Stockbridge SO208DY, Hants, England. EM steven.j.gaydos@us.army.mil NR 92 TC 8 Z9 8 U1 2 U2 10 PU AEROSPACE MEDICAL ASSOC PI ALEXANDRIA PA 320 S HENRY ST, ALEXANDRIA, VA 22314-3579 USA SN 0095-6562 J9 AVIAT SPACE ENVIR MD JI Aviat. Space Environ. Med. PD SEP PY 2012 VL 83 IS 9 BP 879 EP 889 DI 10.3357/ASEM.3274.2012 PG 11 WC Public, Environmental & Occupational Health; Medicine, General & Internal; Sport Sciences SC Public, Environmental & Occupational Health; General & Internal Medicine; Sport Sciences GA 994GO UT WOS:000307919100006 PM 22946352 ER PT J AU Still, DL Temme, LA AF Still, David L. Temme, Leonard A. TI An Independent, Objective Calibration Check for the Reduced Oxygen Breathing Device SO AVIATION SPACE AND ENVIRONMENTAL MEDICINE LA English DT Article DE hypoxia; hypobaric hypoxia; normobaric hypoxia; Reduced Oxygen Breathing Device; ROBD-2 ID HYPOXIA; HUMANS AB STILL DL, TEMME LA. An independent, objective calibration check for the Reduced Oxygen Breathing Device. Aviat Space Environ Med 2012; 83:902-8. Introduction: Normobaric hypoxia, which does not entail an altitude chamber, but reduces the fraction of inspired oxygen (O-2) by diluting air with nitrogen, is finding increased use. The Reduced Oxygen Breathing Device (ROBD-2) is one of several commercial devices for generating such normobaric hypoxia. Reported here are results of a procedure to check the calibration of the ROBD-2 using methods that may be readily available in physiology and psychophysiology facilities. Methods: The %O-2, output by the ROBD-2 was measured concurrently in two ways for altitudes from mean sea level (MSL) to 34,000 ft above MSL at 2000-ft intervals five times over 2 d. One measurement method used was the one built into the ROBD-2, which reports the %O-2, the device is delivering at the selected target altitude. The other method diverted a sample of the ROBD-2's output gas to the paramagnetic O-2 sensor of a metabolic measuring system via its sampling line. The %O-2, measured with the two techniques was compared using Bland-Altman statistical procedures. Results: The two measurement methods produced %O-2 readings differing by no more than 0.18% O-2 from MSL to 34,000 ft (from 20.95 to about 4.40% oxygen, respectively), the full operating range of the device. Calculating altitude from the measured %O-2 showed the ROBD-2 operated within its design error margins over its whole operational range. Discussion: The purpose for which the ROBD-2 is used should determine whether the reliability of its output in normobaric equivalent altitude is adequate. Differences between devices and device stability over time and with use have yet to be assessed. Our assessment does not address the accuracy of the algorithm the ROBD-2 uses to provide an equivalent target altitude under normobaric conditions. C1 [Still, David L.; Temme, Leonard A.] USA, Aeromed Res Lab, Sensory Res Div, Vis Sci Branch, Ft Rucker, AL 36362 USA. RP Still, DL (reprint author), USA, Aeromed Res Lab, Sensory Res Div, Vis Sci Branch, 6901 Andrews Ave, Ft Rucker, AL 36362 USA. EM david.l.still@us.army.mil FU CDMRP Award [W81XWH-08-2-0052] FX The authors wish to acknowledge Dr. Loraine St. Onge, LTC Jose Capo-Aponte, and two anonymous reviewers for their constructive, patient criticism during the preparation of this document. This research was funded in part by the CDMRP Award W81XWH-08-2-0052, The Effects of Hypoxia on Cognitive Function in Aviators and Complex System Operators Who Have Had a Mild Traumatic Brain Injury. NR 14 TC 2 Z9 2 U1 0 U2 1 PU AEROSPACE MEDICAL ASSOC PI ALEXANDRIA PA 320 S HENRY ST, ALEXANDRIA, VA 22314-3579 USA SN 0095-6562 J9 AVIAT SPACE ENVIR MD JI Aviat. Space Environ. Med. PD SEP PY 2012 VL 83 IS 9 BP 902 EP 908 DI 10.3357/ASEM.3046.2012 PG 7 WC Public, Environmental & Occupational Health; Medicine, General & Internal; Sport Sciences SC Public, Environmental & Occupational Health; General & Internal Medicine; Sport Sciences GA 994GO UT WOS:000307919100010 PM 22946356 ER PT J AU Bergeron, MF Bahr, R Bartsch, P Bourdon, L Calbet, JAL Carlsen, KH Castagna, O Gonzalez-Alonso, J Lundby, C Maughan, RJ Millet, G Mountjoy, M Racinais, S Rasmussen, P Singh, DG Subudhi, AW Young, AJ Soligard, T Engebretsen, L AF Bergeron, M. F. Bahr, R. Baertsch, P. Bourdon, L. Calbet, J. A. L. Carlsen, K. H. Castagna, O. Gonzalez-Alonso, J. Lundby, C. Maughan, R. J. Millet, G. Mountjoy, M. Racinais, S. Rasmussen, P. Singh, D. G. Subudhi, A. W. Young, A. J. Soligard, T. Engebretsen, L. TI International Olympic Committee consensus statement on thermoregulatory and altitude challenges for high-level athletes SO BRITISH JOURNAL OF SPORTS MEDICINE LA English DT Article ID EXERCISE-INDUCED BRONCHOCONSTRICTION; ACUTE MOUNTAIN-SICKNESS; MUSCLE BLOOD-FLOW; HIGH-TRAINING LOW; NORMOBARIC HYPOXIA; HEAT ACCLIMATION; INDUCED ASTHMA; INDUCED BRONCHOSPASM; IPRATROPIUM BROMIDE; AEROBIC PERFORMANCE AB Challenging environmental conditions, including heat and humidity, cold, and altitude, pose particular risks to the health of Olympic and other high-level athletes. As a further commitment to athlete safety, the International Olympic Committee (IOC) Medical Commission convened a panel of experts to review the scientific evidence base, reach consensus, and underscore practical safety guidelines and new research priorities regarding the unique environmental challenges Olympic and other international-level athletes face. For non-aquatic events, external thermal load is dependent on ambient temperature, humidity, wind speed and solar radiation, while clothing and protective gear can measurably increase thermal strain and prompt premature fatigue. In swimmers, body heat loss is the direct result of convection at a rate that is proportional to the effective water velocity around the swimmer and the temperature difference between the skin and the water. Other cold exposure and conditions, such as during Alpine skiing, biathlon and other sliding sports, facilitate body heat transfer to the environment, potentially leading to hypothermia and/or frostbite; although metabolic heat production during these activities usually increases well above the rate of body heat loss, and protective clothing and limited exposure time in certain events reduces these clinical risks as well. Most athletic events are held at altitudes that pose little to no health risks; and training exposures are typically brief and well-tolerated. While these and other environment-related threats to performance and safety can be lessened or averted by implementing a variety of individual and event preventative measures, more research and evidence-based guidelines and recommendations are needed. In the mean time, the IOC Medical Commission and International Sport Federations have implemented new guidelines and taken additional steps to mitigate risk even further. C1 [Bergeron, M. F.] Univ S Dakota, Sanford Childrens Hlth Res Ctr, Sanford Sch Med, Dept Paediat, Sioux Falls, SD USA. [Bahr, R.] Norwegian Sch Sport Sci, Oslo Sports Trauma Res Ctr, Dept Sports Med, Oslo, Norway. [Baertsch, P.] Univ Heidelberg Hosp, Dept Internal Med, Div Sports Med 7, Heidelberg, Germany. [Bourdon, L.; Castagna, O.] IRBA EVDG, Ecole Val de Grace, Inst Rech Biomed Def, Paris, France. [Calbet, J. A. L.] Univ Palmas de Gran Canaria, Dept Phys Educ, Las Palmas Gran Canaria, Spain. [Carlsen, K. H.] Univ Oslo, Fac Med, Oslo, Norway. [Carlsen, K. H.] Oslo Univ Hosp, Rikshospitalet, Dept Paediat, Oslo, Norway. [Gonzalez-Alonso, J.] Brunel Univ, Ctr Sports Med & Human Performance, Uxbridge UB8 3PH, Middx, England. [Lundby, C.; Rasmussen, P.] Univ Zurich, ZIHP, Zurich, Switzerland. [Lundby, C.; Rasmussen, P.] Univ Zurich, Inst Physiol, Zurich, Switzerland. [Maughan, R. J.] Univ Loughborough, Sch Sport Exercise & Hlth Sci, Loughborough, Leics, England. [Millet, G.] Univ Lausanne, Fac Biol & Med, ISSUL Inst Sport Sci, Dept Physiol, Lausanne, Switzerland. [Mountjoy, M.] Federat Int Natat, Med Commiss, Lausanne, Switzerland. [Mountjoy, M.] Int Olymp Comm, Med Commiss, Lausanne, Switzerland. [Mountjoy, M.] McMaster Univ, Hamilton, ON, Canada. [Racinais, S.] ASPETAR, Qatar Orthopaed & Sports Med Hosp, Res & Educ Ctr, Doha, Qatar. [Rasmussen, P.] Univ Copenhagen, Dept Neurosci & Pharmacol, Copenhagen, Denmark. [Singh, D. G.] Federat Int Football Assoc, Med Comm, Zurich, Switzerland. [Singh, D. G.] Badminton World Federat, Med Commiss, Kuala Lumpur, Malaysia. [Singh, D. G.] Asian Football Confederat, Med Comm, Kuala Lumpur, Malaysia. [Subudhi, A. W.] Univ Colorado, Dept Biol, Colorado Springs, CO 80907 USA. [Subudhi, A. W.] Univ Colorado, Altitude Res Ctr, Colorado Springs, CO 80907 USA. [Young, A. J.] USA, Environm Med Res Inst, Mil Nutr Div, Natick, MA USA. [Soligard, T.; Engebretsen, L.] Int Olymp Comm, Med & Sci Dept, Lausanne, Switzerland. RP Engebretsen, L (reprint author), Univ Oslo, IOC Med & Sci Dept, Kirkeveien 111, N-0407 Oslo, Norway. EM lars.engebretsen@medisin.uio.no RI Millet, Gregoire/F-4104-2012; Rasmussen, Peter/B-8203-2013; Bahr, Roald/B-6964-2014; maughan, ron/G-5370-2016; Calbet, Jose A/H-6693-2015; OI Millet, Gregoire/0000-0001-8081-4423; Rasmussen, Peter/0000-0003-1761-4562; maughan, ron/0000-0002-7642-354X; Calbet, Jose A/0000-0002-9215-6234; Bahr, Roald/0000-0001-5725-4237; Soligard, Torbjorn/0000-0001-8863-4574 NR 99 TC 41 Z9 42 U1 6 U2 54 PU BMJ PUBLISHING GROUP PI LONDON PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND SN 0306-3674 J9 BRIT J SPORT MED JI Br. J. Sports Med. PD SEP PY 2012 VL 46 IS 11 BP 770 EP 779 DI 10.1136/bjsports-2012-091296 PG 10 WC Sport Sciences SC Sport Sciences GA 996EP UT WOS:000308067600002 PM 22685119 ER PT J AU Castellani, JW Young, AJ AF Castellani, John William Young, Andrew John TI Health and performance challenges during sports training and competition in cold weather SO BRITISH JOURNAL OF SPORTS MEDICINE LA English DT Review ID EXERCISE; THERMOREGULATION; HYPOTHERMIA; HYPOGLYCEMIA; TEMPERATURE; RESPONSES; EXPOSURE; FATIGUE; STRESS AB Olympic athletes compete and train in diverse cold-weather environments, generally without adverse effects. However, the nature of some sports may increase the risk of cold injuries. This paper provides guidance to enable competition organisers and officials, coaches and athletes to avoid cold-weather injuries. This paper will (1) define potential cold-weather injuries during training and competition and (2) provide risk management guidance to mitigate susceptibility to cold-weather injuries. C1 [Young, Andrew John] USA, Environm Med Res Inst, Mil Nutr Div, Natick, MA 01760 USA. [Castellani, John William] USA, Environm Med Res Inst, Thermal & Mt Med Div, Natick, MA USA. RP Young, AJ (reprint author), USA, Environm Med Res Inst, Mil Nutr Div, 42 Kansas St, Natick, MA 01760 USA. EM andrew.j.young@us.army.mil FU US Army Medical Research and Materiel Command (USAMRMC) FX The views, opinions and/or findings in this report are those of the authors, and should not be construed as an official Department of the Army position, policy or decision, unless so designated by other official documentation. This work was supported by the US Army Medical Research and Materiel Command (USAMRMC). NR 23 TC 3 Z9 3 U1 4 U2 30 PU B M J PUBLISHING GROUP PI LONDON PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND SN 0306-3674 J9 BRIT J SPORT MED JI Br. J. Sports Med. PD SEP PY 2012 VL 46 IS 11 BP 788 EP + DI 10.1136/bjsports-2012-091260 PG 5 WC Sport Sciences SC Sport Sciences GA 996EP UT WOS:000308067600004 PM 22906781 ER PT J AU Clark, PJ Thompson, AJ Zhu, QQ Vock, DM Zhu, MF Patel, K Harrison, SA Naggie, S Ge, DL Tillmann, HL Urban, TJ Shianna, K Fellay, J Goodman, Z Noviello, S Pedicone, LD Afdhal, N Sulkowski, M Albrecht, JK Goldstein, DB McHutchison, JG Muir, AJ AF Clark, Paul J. Thompson, Alexander J. Zhu, Qianqian Vock, David M. Zhu, Mingfu Patel, Keyur Harrison, Stephen A. Naggie, Susanna Ge, Dongliang Tillmann, Hans L. Urban, Thomas J. Shianna, Kevin Fellay, Jacques Goodman, Zachary Noviello, Stephanie Pedicone, Lisa D. Afdhal, Nezam Sulkowski, Mark Albrecht, Janice K. Goldstein, David B. McHutchison, John G. Muir, Andrew J. TI The Association of Genetic Variants with Hepatic Steatosis in Patients with Genotype 1 Chronic Hepatitis C Infection (vol 57, pg 2213, 2012) SO DIGESTIVE DISEASES AND SCIENCES LA English DT Correction C1 [Clark, Paul J.; Thompson, Alexander J.; Vock, David M.; Patel, Keyur; Naggie, Susanna; Tillmann, Hans L.; McHutchison, John G.; Muir, Andrew J.] Duke Univ, Duke Clin Res Inst, Durham, NC 27715 USA. [Clark, Paul J.] Univ New S Wales, Kirby Inst Infect & Immun Soc, Kensington, NSW 2033, Australia. [Zhu, Qianqian; Zhu, Mingfu; Ge, Dongliang; Urban, Thomas J.; Shianna, Kevin; Fellay, Jacques; Goldstein, David B.] Duke Univ, Ctr Human Genome Variat, Durham, NC 27715 USA. [Harrison, Stephen A.] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. [Goodman, Zachary] Armed Forces Inst Pathol, Washington, DC 20306 USA. [Noviello, Stephanie; Pedicone, Lisa D.; Albrecht, Janice K.] Merck & Co Inc, Whitehouse Stn, NJ USA. [Afdhal, Nezam] Beth Israel Deaconess Med Ctr, Boston, MA 02215 USA. [Sulkowski, Mark] Johns Hopkins Univ, Sch Med, Baltimore, MD USA. RP Clark, PJ (reprint author), Duke Univ, Duke Clin Res Inst, POB 17969, Durham, NC 27715 USA. EM drpjclark@gmail.com; muir0002@mc.duke.edu RI Zhu, Mingfu/F-3217-2011; Clark, Paul/A-1480-2012; Fellay, Jacques/A-6681-2009 OI Zhu, Mingfu/0000-0003-0296-712X; Clark, Paul/0000-0002-1821-4969; Fellay, Jacques/0000-0002-8240-939X NR 1 TC 0 Z9 0 U1 0 U2 1 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0163-2116 J9 DIGEST DIS SCI JI Dig. Dis. Sci. PD SEP PY 2012 VL 57 IS 9 BP 2479 EP 2479 DI 10.1007/s10620-012-2309-y PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 995VW UT WOS:000308043300038 ER PT J AU Kingseed, CCC AF Kingseed, Colonel Cole C. TI Pacific Crucible: War at Sea in the Pacific, 1941-1942 SO HISTORIAN LA English DT Book Review C1 [Kingseed, Colonel Cole C.] USA, Washington, DC 20310 USA. RP Kingseed, CCC (reprint author), USA, Washington, DC 20310 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0018-2370 J9 HISTORIAN JI Historian PD FAL PY 2012 VL 74 IS 3 BP 602 EP 603 DI 10.1111/j.1540-6563.2012.00328_39.x PG 2 WC History SC History GA 999IO UT WOS:000308303300043 ER PT J AU Yeager, JJ Facemire, P Dabisch, PA Robinson, CG Nyakiti, D Beck, K Baker, R Pitt, MLM AF Yeager, John J. Facemire, Paul Dabisch, Paul A. Robinson, Camenzind G. Nyakiti, David Beck, Katie Baker, Reese Pitt, M. Louise M. TI Natural History of Inhalation Melioidosis in Rhesus Macaques (Macaca mulatta) and African Green Monkeys (Chlorocebus aethiops) SO INFECTION AND IMMUNITY LA English DT Article ID BURKHOLDERIA-PSEUDOMALLEI; BALB/C MICE; INFECTION; MODEL; EPIDEMIOLOGY; NEUTROPHILS; EXPRESSION; THAILAND; IMMUNITY; SYSTEM AB Burkholderia pseudomallei, the causative agent of melioidosis, is recognized as a serious health threat due to its involvement in septic and pulmonary infections in areas of endemicity and is recognized by the Centers for Disease Control and Prevention as a category B biothreat agent. An animal model is desirable to evaluate the pathogenesis of melioidosis and medical countermeasures. A model system that represents human melioidosis infections is essential in this process. A group of 10 rhesus macaques (RMs) and 10 African green monkeys (AGMs) was exposed to aerosolized B. pseudomallei 1026b. The first clinical signs were fever developing 24 to 40 h postexposure followed by leukocytosis resulting from a high percentage of neutrophils. Dyspnea manifested 2 to 4 days postexposure. In the AGMs, an increase in interleukin 1 beta (IL-1 beta), IL-6, IL-8, gamma interferon (IFN-gamma), and tumor necrosis factor alpha (TNF-alpha) was observed. In the RMs, IL-1 beta, IL-6, and TNF-alpha increased. All the RMs and AGMs had various degrees of bronchopneumonia, with inflammation consisting of numerous neutrophils and a moderate number of macrophages. Both the RMs and the AGMs appear to develop a melioidosis infection that closely resembles that seen in acute human melioidosis. However, for an evaluation of medical countermeasures, AGMs appear to be a more appropriate model. C1 [Yeager, John J.; Dabisch, Paul A.; Nyakiti, David; Baker, Reese; Pitt, M. Louise M.] USA, Med Res Inst Infect Dis, Ctr Aerobiol Sci, Ft Detrick, MD 21702 USA. [Facemire, Paul; Robinson, Camenzind G.] USA, Med Res Inst Infect Dis, Div Pathol, Ft Detrick, MD 21702 USA. [Beck, Katie] Keaki Technol LLC, Frederick, MD USA. RP Yeager, JJ (reprint author), USA, Med Res Inst Infect Dis, Ctr Aerobiol Sci, Ft Detrick, MD 21702 USA. EM john.yeager3@us.army.mil FU Defense Threat Reduction Agency-Transformational Medical Technology Initiative [108574] FX This project was supported by the Defense Threat Reduction Agency-Transformational Medical Technology Initiative, plan number 108574. NR 43 TC 17 Z9 17 U1 0 U2 4 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0019-9567 J9 INFECT IMMUN JI Infect. Immun. PD SEP PY 2012 VL 80 IS 9 BP 3332 EP 3340 DI 10.1128/IAI.00675-12 PG 9 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 993ON UT WOS:000307869100034 PM 22778104 ER PT J AU Eller, MA Eller, LA Ratto-Kim, S Ouma, BJ Lo, V de Souza, M Guwatudde, D Nails, B Michael, NL Wabwire-Mangen, F Robb, ML Marovich, MA Sandberg, JK Currier, JR AF Eller, Michael A. Eller, Leigh Anne Ratto-Kim, Silvia Ouma, Benson J. Lo, Vicky de Souza, Mark Guwatudde, David Nails, Barbara Michael, Nelson L. Wabwire-Mangen, Fred Robb, Merlin L. Marovich, Mary A. Sandberg, Johan K. Currier, Jeffrey R. TI Single-Cell Level Response of HIV-Specific and Cytomegalovirus-Specific CD4 T Cells Correlate With Viral Control in Chronic HIV-1 Subtype A Infection SO JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES LA English DT Article DE T cells; HIV-1; AIDS; viral infections; memory ID VIRUS TYPE-1 INFECTION; IMMUNODEFICIENCY-VIRUS; DISEASE PROGRESSION; EFFECTOR FUNCTIONS; RAKAI DISTRICT; GENETIC NEUTROPENIA; VIREMIA; MEMORY; UGANDA; LYMPHOCYTES AB Background and Objective: HIV-1 subtype A is the second most prevalent subtype globally and is associated with reduced viral load, higher CD4 absolute counts, and slower disease progression. To study the possible role of T cells associated with better outcome, we examined CD4 and CD8 T-cell responses against HIV-1 and cytomegalovirus (CMV) in Ugandans infected with subtype A HIV-1. Methods: T-cell responses were investigated using flow cytometry and novel subtype A variant inclusive peptide (VIP) sets designed for this evaluation. CD4 T-cell responses focused primarily on Gag, whereas CD8 T-cell responses were broadly directed against Gag, gp41, and Nef VIP sets. CD4 T cells primarily responded with interferon (IFN)-gamma, whereas CD8 cells were more diverse with degranulation (CD107a), IFN-gamma, and macrophage inflammatory protein (MIP)-1 beta production. Results: No relationship was observed between CD8 T-cell responses and the HIV-1 load. Similarly, the frequency of CD4 T cells responding to these antigens did not associate with viral control. However, in CD4 T cells responding against Gag or CMV, the IFN-gamma intensity, indicative of the production at the single-cell level, was inversely proportional to viral load. No significant relationship was found between T-cell effector/memory phenotype and viral control. Conclusions: The per cell production of IFN-gamma in CD4 T cells responding to HIV-1 or CMV correlated with viral control in chronic HIV-1 subtype A infection. These data suggest that quantitative aspects at the single-cell level may be more important than the frequency of antigen-specific CD4 T cells in HIV-1 subtype A infection control. C1 [Eller, Michael A.; Eller, Leigh Anne; Ratto-Kim, Silvia; Lo, Vicky; Nails, Barbara; Michael, Nelson L.; Robb, Merlin L.; Marovich, Mary A.; Currier, Jeffrey R.] US Mil HIV Res Program, Silver Spring, MD 20910 USA. [Eller, Michael A.; Sandberg, Johan K.] Karolinska Inst, Ctr Infect Med, Stockholm, Sweden. [Ouma, Benson J.; Guwatudde, David; Wabwire-Mangen, Fred] Makerere Univ, Walter Reed Project, Kampala, Uganda. [de Souza, Mark] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Guwatudde, David; Wabwire-Mangen, Fred] Makerere Univ, Sch Publ Hlth, Kampala, Uganda. RP Eller, MA (reprint author), US Mil HIV Res Program, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM meller@hivresearch.org OI Sandberg, Johan/0000-0002-6275-0750 NR 48 TC 3 Z9 3 U1 1 U2 4 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1525-4135 J9 JAIDS-J ACQ IMM DEF JI JAIDS PD SEP 1 PY 2012 VL 61 IS 1 BP 9 EP 18 DI 10.1097/QAI.0b013e31825c1217 PG 10 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 999YO UT WOS:000308352000008 PM 22580564 ER PT J AU Taylor, PJ Maddux, JR Uppal, PN AF Taylor, Patrick J. Maddux, Jay R. Uppal, Parvez N. TI Measurement of Thermal Conductivity Using Steady-State Isothermal Conditions and Validation by Comparison with Thermoelectric Device Performance SO JOURNAL OF ELECTRONIC MATERIALS LA English DT Article DE Thermoelectric power generation; thermal conductivity; Seebeck coefficient ID TELLURIDE AB A new technique for measuring thermal conductivity with significantly improved accuracy is presented. By using the Peltier effect to counterbalance an imposed temperature difference, a completely isothermal, steady-state condition can be obtained across a sample. In this condition, extraneous parasitic heat flows that would otherwise cause error can be eliminated entirely. The technique is used to determine the thermal conductivity of p-type and n-type samples of (Bi,Sb)(2)(Te,Se)(3) materials, and thermal conductivity values of 1.47 W/m K and 1.48 W/m K are obtained respectively. To validate this technique, those samples were assembled into a Peltier cooling device. The agreement between the Seebeck coefficient measured individually and from the assembled device were within 0.5%, and the corresponding thermal conductivity was consistent with the individual measurements with less than 2% error. C1 [Taylor, Patrick J.; Maddux, Jay R.; Uppal, Parvez N.] USA, Sensors & Electron Devices Directorate, Res Lab, Adelphi, MD 20783 USA. RP Taylor, PJ (reprint author), USA, Sensors & Electron Devices Directorate, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM patrick.j.taylor36.civ@mail.mil FU Defense Advanced Research Projects Agency (DARPA) under the Active Cooling Modules program FX The authors would like to acknowledge the support from the Defense Advanced Research Projects Agency (DARPA) under the Active Cooling Modules program. NR 11 TC 3 Z9 3 U1 1 U2 10 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0361-5235 J9 J ELECTRON MATER JI J. Electron. Mater. PD SEP PY 2012 VL 41 IS 9 BP 2307 EP 2312 DI 10.1007/s11664-012-2178-3 PG 6 WC Engineering, Electrical & Electronic; Materials Science, Multidisciplinary; Physics, Applied SC Engineering; Materials Science; Physics GA 985SF UT WOS:000307289400001 ER PT J AU Cheng, SF Tom, K Pecht, M AF Cheng, Shunfeng Tom, Kwok Pecht, Michael TI Failure Causes of a Polymer Resettable Circuit Protection Device SO JOURNAL OF ELECTRONIC MATERIALS LA English DT Article DE Resettable circuit protection devices; polymer positive-temperature-coefficient effect; failure mode; failure cause analysis; reliability ID POSITIVE-TEMPERATURE-COEFFICIENT; HIGH-DENSITY POLYETHYLENE; CARBON-BLACK; HEALTH MANAGEMENT; COMPOSITES; RESISTIVITY; ELECTRONICS; PROGNOSTICS; SYSTEMS AB As a circuit protection device, failure or abnormal behavior of polymer positive-temperature-coefficient resettable devices can cause damage to circuits. Identification of failure modes and determination of failure causes are necessary to improve the reliability of resettable circuit protection devices and understand their limitations. In this study, a series of experiments was conducted to identify the failure modes of polymer positive-temperature- coefficient resettable circuit protection devices. The causes of failures of a polymer positive-temperature-coefficient resettable circuit protection device were determined by failure analyses, including analysis of the increase in surface temperature using an infrared camera, interconnection analysis using cross-sectioning and environmental scanning electron microscopy, analysis of the microstructures of carbon-black-filled polymer composite, thermal property analysis of the polymer composite, and coefficient of thermal expansion analysis of different parts of the resettable circuit protection device. C1 [Cheng, Shunfeng; Pecht, Michael] Univ Maryland, CALCE, College Pk, MD 20742 USA. [Tom, Kwok] USA, Res Lab, Adelphi, MD 20783 USA. [Pecht, Michael] City Univ Hong Kong, Prognost & Hlth Management Ctr, Hong Kong, Hong Kong, Peoples R China. RP Cheng, SF (reprint author), Intel Corp, Hillsboro, OR 97124 USA. EM shunfengcheng@gmail.com; kwok.tom.civ@mail.mil; pecht@calce.umd.edu OI Pecht, Michael/0000-0003-1126-8662 NR 20 TC 0 Z9 0 U1 0 U2 10 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0361-5235 J9 J ELECTRON MATER JI J. Electron. Mater. PD SEP PY 2012 VL 41 IS 9 BP 2419 EP 2430 DI 10.1007/s11664-012-2148-9 PG 12 WC Engineering, Electrical & Electronic; Materials Science, Multidisciplinary; Physics, Applied SC Engineering; Materials Science; Physics GA 985SF UT WOS:000307289400019 ER PT J AU Morelli, JN Ai, F Runge, VM Zhang, W Li, XM Schmitt, P McNeal, G Michaely, HJ Schoenberg, SO Miller, M Gerdes, CM Sincleair, ST Spratt, H Attenberger, UI AF Morelli, John N. Ai, Fei Runge, Val M. Zhang, Wei Li, Xiaoming Schmitt, Peter McNeal, Gary Michaely, Henrick J. Schoenberg, Stefan O. Miller, Matthew Gerdes, Clint M. Sincleair, Spencer T. Spratt, Heidi Attenberger, Ulrike I. TI Time-resolved MR angiography of renal artery stenosis in a swine model at 3 Tesla using gadobutrol with digital subtraction angiography correlation SO JOURNAL OF MAGNETIC RESONANCE IMAGING LA English DT Article DE MRA; gadobutrol; time-resolved MRA ID MAGNETIC-RESONANCE ANGIOGRAPHY; NEPHROGENIC SYSTEMIC FIBROSIS; BRAIN GLIOMA MODEL; GADOBENATE DIMEGLUMINE; 3.0 T; GADOPENTETATE DIMEGLUMINE; OCCLUSIVE DISEASE; CONTRAST AGENTS; IMAGE QUALITY; ENHANCED MRA AB Purpose: To establish the minimum dose required for detection of renal artery stenosis using high temporal resolution, contrast enhanced MR angiography (MRA) in a porcine model. Materials and Methods: Surgically created renal artery stenoses were imaged with 3 Tesla MR and digital subtraction angiography (DSA) in 12 swine in this IACUC approved protocol. Gadobutrol was injected intravenously at doses of 0.5, 1, 2, and 4 mL for time-resolved MRA (1.5 x 1.5 mm2 spatial resolution). Region of interest analysis was performed together with stenosis assessment and qualitative evaluation by two blinded readers. Results: Mean signal to noise ratio (SNR) and contrast to noise ratio (CNR) values were statistically significantly less with the 0.5-mL protocol (P < 0.001). There were no statistically significant differences among the other evaluated doses. Both readers found 10/12 cases with the 0.5-mL protocol to be of inadequate diagnostic quality (? = 1.0). All other scans were found to be adequate for diagnosis. Accuracies in distinguishing between mild/insignificant (<50%) and higher grade stenoses (>50%) were comparable among the higher-dose protocols (sensitivities 7393%, specificities 62100%). Conclusion: Renal artery stenosis can be assessed with very low doses ( 0.025 mmol/kg bodyweight) of a high concentration, high relaxivity gadolinium chelate formulation in a swine model, results which are promising with respect to limiting exposure to gadolinium based contrast agents. J. Magn. Reson. Imaging 2012;36:704713. (C) 2012 Wiley Periodicals, Inc. C1 [Ai, Fei; Zhang, Wei; Li, Xiaoming] Huazhong Univ Sci & Technol, Tongji Hosp, Dept Radiol, Wuhan 430074, Hubei, Peoples R China. [Morelli, John N.; Gerdes, Clint M.; Sincleair, Spencer T.] Texas A&M Univ, Scott & White Clin & Hosp, Hlth Sci Ctr, Dept Radiol, Temple, TX USA. [Runge, Val M.] UTMB, Dept Radiol, Galveston, TX USA. [Schmitt, Peter] Siemens Healthcare Erlangen, Bavaria, Germany. [McNeal, Gary] USA, Siemens Med Solut, Dallas, TX USA. [Michaely, Henrick J.; Schoenberg, Stefan O.; Attenberger, Ulrike I.] Univ Med Ctr Mannheim, Inst Clin Radiol & Nucl Med, Mannheim, Baden Wurttembe, Germany. [Miller, Matthew] Texas A&M Univ, Inst Preclin Studies TIPS, College Stn, TX USA. [Spratt, Heidi] UTMB, Bioinformat Program, Galveston, TX USA. RP Li, XM (reprint author), Huazhong Univ Sci & Technol, Tongji Hosp, Dept Radiol, Wuhan 430074, Hubei, Peoples R China. EM lilyboston2002@163.com NR 37 TC 5 Z9 6 U1 1 U2 10 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1053-1807 J9 J MAGN RESON IMAGING JI J. Magn. Reson. Imaging PD SEP PY 2012 VL 36 IS 3 BP 704 EP 713 DI 10.1002/jmri.23696 PG 10 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA 994MM UT WOS:000307934900021 PM 22645046 ER PT J AU Stinner, DJ Hsu, JR Wenke, JC AF Stinner, Daniel J. Hsu, Joseph R. Wenke, Joseph C. TI Negative Pressure Wound Therapy Reduces the Effectiveness of Traditional Local Antibiotic Depot in a Large Complex Musculoskeletal Wound Animal Model SO JOURNAL OF ORTHOPAEDIC TRAUMA LA English DT Article DE Negative pressure wound therapy; local antibiotics; bead pouch; orthopaedic infection ID VACUUM-ASSISTED CLOSURE; IMPREGNATED POLYMETHYLMETHACRYLATE BEADS; SURGICAL INCISIONS; TRAUMA; FRACTURES; DIFFUSION; OUTCOMES; RELEASE; BONE AB Objectives: Negative pressure wound therapy (NPWT) has been used to help manage open wounds. Surgeons also often use local antibiotic depot as adjunctive therapy in an effort to reduce infection rates. These 2 techniques have been reported to be used in conjunction, but there are little data to support this practice. We sought to compare the contamination levels of wounds treated with the commonly used antibiotic bead pouch technique to wounds that received both antibiotic beads and NWPT. Methods: The effectiveness of a bead pouch was compared with antibiotic beads with NPWT. The anterior compartment and proximal tibia of goats were injured and inoculated with Staphylococcus aureus. Six hours later, the wounds were debrided and the animals were assigned to a group; the bacteria level was quantified immediately before and after initial debridement and 2 days after treatment. Results: The wounds in the antibiotic bead pouch group had 6-fold less bacteria than the augmented NPWT group, 11 + 2% versus 67 + 11% of baseline values, respectively (P = 0.01). As expected, high levels of the antibiotic were consistently recovered from the augmented NPWT effluent samples at all time points. Conclusions: NPWT reduces the effectiveness of local antibiotic depot. These results can provide surgeons with the information to personalize the adjunctive therapies to individual patients, with the degree of difficulty in managing the wound and concern for infection being the 2 variables dictating treatment. C1 [Stinner, Daniel J.; Wenke, Joseph C.] USA, Dept Regenerat Med, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Hsu, Joseph R.] Brooke Army Med Ctr, Dept Orthopaed & Rehabil, Ft Sam Houston, TX 78234 USA. RP Stinner, DJ (reprint author), USA, Dept Regenerat Med, Inst Surg Res, 3400 Rawley E Chambers Ave, Ft Sam Houston, TX 78234 USA. EM daniel.stinner@gmail.com OI Stinner, Daniel/0000-0002-8981-6262 FU intramural federal funding FX This project was supported by intramural federal funding. NR 30 TC 14 Z9 14 U1 1 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0890-5339 J9 J ORTHOP TRAUMA JI J. Orthop. Trauma PD SEP PY 2012 VL 26 IS 9 BP 512 EP 518 DI 10.1097/BOT.0b013e318251291b PG 7 WC Orthopedics; Sport Sciences SC Orthopedics; Sport Sciences GA 999YQ UT WOS:000308352200016 PM 22495524 ER PT J AU Jernajczyk, W Musinska, I Wolkow, L Jakubczyk, T West, B Latka, M AF Jernajczyk, W. Musinska, I. Wolkow, L. Jakubczyk, T. West, B. Latka, M. TI Respiration sinus arrhythmia during sleep SO JOURNAL OF SLEEP RESEARCH LA English DT Meeting Abstract CT 21st Congress of the European-Sleep-Research-Society CY SEP 04-08, 2012 CL Paris, FRANCE SP European Sleep Res Soc C1 [Jernajczyk, W.; Musinska, I.; Wolkow, L.; Jakubczyk, T.] Inst Psychiat & Neurol, Warsaw, Poland. [West, B.] USA, Math & Informat Sci Directorate, Res Off, Durham, NC USA. [Latka, M.] Wroclaw Univ Technol, PL-50370 Wroclaw, Poland. NR 0 TC 0 Z9 0 U1 0 U2 1 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0962-1105 J9 J SLEEP RES JI J. Sleep Res. PD SEP PY 2012 VL 21 SU 1 SI SI BP 286 EP 286 PG 1 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA 994VV UT WOS:000307963201247 ER PT J AU Streubel, PN Stinner, DJ Obremskey, WT AF Streubel, Philipp N. Stinner, Daniel J. Obremskey, William T. TI Use of Negative-pressure Wound Therapy in Orthopaedic Trauma SO JOURNAL OF THE AMERICAN ACADEMY OF ORTHOPAEDIC SURGEONS LA English DT Review ID VACUUM-ASSISTED CLOSURE; SOFT-TISSUE INJURIES; SEALING-TECHNIQUE; OPEN FRACTURES; TRIAL; CONTAMINATION; INFECTIONS; EXPERIENCE; MANAGEMENT; DRESSINGS AB Negative-pressure wound therapy (NPWT) has become an important adjunct to the management of traumatic wounds and surgical incisions related to musculoskeletal trauma. On the battlefield, this adjunct therapy allows early wound management and safe aeromedical evacuation. NPWT mechanisms of action include stabilization of the wound environment, reduction of wound edema, improvement of tissue perfusion, and stimulation of cells at the wound surface. NPWT stimulates granulation tissue and angiogenesis and may improve the likelihood of primary closure and reduce the need for free tissue transfer. In addition, NPWT reduces the bacterial bioburden of wounds contaminated with gram-negative bacilli. However, an increased risk of colonization of gram-positive cocci (eg, Staphylococcus aureus) exists. Although NPWT facilitates wound management, further research is required to determine conclusively whether this modality is superior to other management options. Ongoing research will continue to define the indications for and benefits of NPWT as well as establish the role of combination therapy, in which NPWT is used with instillation of antibiotic solutions, placement of antibiotic-laden cement beads, or silver-impregnated sponges. C1 [Streubel, Philipp N.; Obremskey, William T.] Vanderbilt Univ, Ctr Med, Div Orthopaed Trauma, Nashville, TN 37232 USA. [Stinner, Daniel J.] Brooke Army Med Ctr, San Antonio, TX USA. RP Streubel, PN (reprint author), Vanderbilt Univ, Ctr Med, Div Orthopaed Trauma, Nashville, TN 37232 USA. OI Streubel, Philipp/0000-0002-4585-1779; Stinner, Daniel/0000-0002-8981-6262 NR 41 TC 16 Z9 23 U1 0 U2 9 PU AMER ACAD ORTHOPAEDIC SURGEONS PI ROSEMENT PA 6300 N RIVER ROAD, ROSEMENT, IL 60018-4262 USA SN 1067-151X J9 J AM ACAD ORTHOP SUR JI J. Am. Acad. Orthop. Surg. PD SEP PY 2012 VL 20 IS 9 BP 564 EP 574 DI 10.5435/JAAOS-20-09-564 PG 11 WC Orthopedics; Surgery SC Orthopedics; Surgery GA 000JK UT WOS:000308382400003 PM 22941799 ER PT J AU Markov, NP DuBose, JJ Scott, D Propper, BW Clouse, WD Thompson, B Blackbourne, LH Rasmussen, TE AF Markov, Nickolay P. DuBose, Joseph J. Scott, Daniel Propper, Brandon W. Clouse, W. Darrin Thompson, Billy Blackbourne, Lorne H. Rasmussen, Todd E. TI Anatomic distribution and mortality of arterial injury in the wars in Afghanistan and Iraq with comparison to a civilian benchmark SO JOURNAL OF VASCULAR SURGERY LA English DT Article ID TRAUMA-DATA-BANK; EXTREMITY VASCULAR INJURY; PENETRATING FEMOROPOPLITEAL INJURY; DAMAGE CONTROL RESUSCITATION; OPERATION-ENDURING-FREEDOM; COMBAT CASUALTY CARE; BALAD AIR BASE; COMPLETE MANAGEMENT; LOCAL-POPULATION; CONTROL ADJUNCT AB Objective: The purpose of this study was to examine the anatomic distribution and associated mortality of combat-related vascular injuries comparing them to a contemporary civilian standard. Design: The Joint Trauma Theater Registry (JTTR) was queried to identify patients with major compressible arterial injury (CAI) and noncompressible arterial injury (NCAI) sites, and their outcomes, among casualties in Iraq and Afghanistan from 2003 to 2006. The National Trauma Data Bank (NTDB) was then queried over the same time frame to identify civilian trauma patients with similar arterial injuries. Propensity score-based matching was used to create matched patient cohorts from both populations for analysis. Results: Registry queries identified 380 patients from the JTTR and 7020 patients from the NTDB who met inclusion criteria. Propensity score matching for age, elevated Injury Severity Score (ISS; >15), and hypotension on arrival (systolic blood pressure [SBP] <90) resulted in 167 matched patients from each registry. The predominating mechanism of injury among matched JTTR patients was explosive events (73.1%), whereas penetrating injury was more common in the NTDB group (61.7%). In the matched cohorts, the incidence of NCAI did not differ (22.2% JTTR vs 26.6% NTDB; P = .372), but the NTDB patients had a higher incidence of CAI (73.7% vs 59.3%; P = .005). The JTTR cohort was also found to have a higher incidence of associated venous injury (57.5% vs 23.4%; P < .001). Overall, the matched JTTR cohort had a lower mortality than NTDB counterparts (4.2% vs 12.6%; P = .006), a finding that was also noted among patients with NCAI (10.8% vs 36.4%; P = .008). There was no difference in mortality between matched JTTR and NTDB patients with CAI overall (2.0% vs 4.1%; P = .465), or among those presenting with Glasgow Coma Scale (GCS) < 8 (28.6% vs 40.0%; P = 1.00) or shock (SBP < 90; 10.5% vs 7.7%; P = 1.00). The JTTR mortality rate among patients with CAI was, however, lower among patients with ISS >15 compared with civilian matched counterparts (10.7% vs 42.4%; P = .006). Conclusions: Mortality of injured service personnel who reach a medical treatment facility after major arterial injury compares favorably to a matched civilian standard. Acceptable mortality rates within the military cohort are related to key aspects of an organized Joint Trauma System, including prehospital tactical combat casualty care, rapid medical evacuation to forward surgical capability, and implementation of clinical practice guidelines. Aspects of this comprehensive combat casualty care strategy may translate and be of value to management of arterial injury in the civilian sector. (J Vasc Surg 2012;56:728-36.) C1 [Markov, Nickolay P.; Scott, Daniel; Propper, Brandon W.; Clouse, W. Darrin; Thompson, Billy; Blackbourne, Lorne H.; Rasmussen, Todd E.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [DuBose, Joseph J.] USAF, Ctr Sustainment Trauma Readiness & Skills C STARS, Baltimore, MD USA. RP Rasmussen, TE (reprint author), USA, Inst Surg Res, 3698 Chambers Pass, Ft Sam Houston, TX 78234 USA. EM todd.rasmussen@amedd.army.mil NR 47 TC 17 Z9 20 U1 0 U2 0 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0741-5214 J9 J VASC SURG JI J. Vasc. Surg. PD SEP PY 2012 VL 56 IS 3 BP 728 EP 736 DI 10.1016/j.jvs.2012.02.048 PG 9 WC Surgery; Peripheral Vascular Disease SC Surgery; Cardiovascular System & Cardiology GA 996KM UT WOS:000308085500020 PM 22795520 ER PT J AU Sluss, DM Thompson, BS AF Sluss, David M. Thompson, Bryant S. TI Socializing the newcomer: The mediating role of leader-member exchange SO ORGANIZATIONAL BEHAVIOR AND HUMAN DECISION PROCESSES LA English DT Article DE Newcomer adjustment; Socialization; Social exchange theory; Leader-member exchange; Identification; Person-organization fit ID PERCEIVED ORGANIZATIONAL SUPPORT; CONFIRMATORY FACTOR-ANALYSIS; IDENTITY THEORY; SCALE LMX-6; TACTICS; WORK; FIT; IDENTIFICATION; ADJUSTMENT; BEHAVIOR AB We expand organizational socialization research by integrating social exchange theory, specifically leader-member exchange (LMX), as an important mediator in explaining newcomer attachment to the job, occupation, and organization. Using temporally-lagged data from 213 newcomers across 12 telemarketing organizations, we found that newcomer perceptions of LMX mediate the association between supervisory socialization tactics (i.e. supervisory job-focused advice, guidance, and role modeling) and occupational identification as well as between supervisory socialization tactics and perceived person-organization fit - but not between supervisory socialization tactics and job satisfaction. Our study specifies (1) LMX as a compelling mediating mechanism within the new employee 'on-boarding' process and (2) the immediate supervisor as an important relational source for newcomer attitudes. (C) 2012 Elsevier Inc. All rights reserved. C1 [Sluss, David M.] Georgia Inst Technol, Coll Management, Atlanta, GA 30332 USA. [Thompson, Bryant S.] US Mil Acad, Dept Behav Sci & Leadership, West Point, NY 10996 USA. RP Sluss, DM (reprint author), Georgia Inst Technol, Coll Management, Atlanta, GA 30332 USA. EM david.sluss@mgt.gatech.edu; bryant.thompson@usma.edu NR 111 TC 20 Z9 20 U1 3 U2 109 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0749-5978 J9 ORGAN BEHAV HUM DEC JI Organ. Behav. Hum. Decis. Process. PD SEP PY 2012 VL 119 IS 1 BP 114 EP 125 DI 10.1016/j.obhdp.2012.05.005 PG 12 WC Psychology, Applied; Management; Psychology, Social SC Psychology; Business & Economics GA 994DN UT WOS:000307911200010 ER PT J AU Rahman, MM Hosur, M Ludwick, AG Zainuddin, S Kumar, A Trovillion, J Jeelani, S AF Rahman, Muhammad M. Hosur, Mahesh Ludwick, Adriane G. Zainuddin, Shaik Kumar, Ashok Trovillion, Jonathan Jeelani, Shaik TI Thermo-mechanical behavior of epoxy composites modified with reactive polyol diluent and randomly-oriented amino-functionalized multi-walled carbon nanotubes SO POLYMER TESTING LA English DT Article DE Nanocomposites; Carbon nanotubes; Thermo-mechanical properties; Toughener ID TOUGHENING MECHANISMS; PHASE-SEPARATION; FRACTURE ENERGY; FREE-VOLUME; NANOCOMPOSITES; MORPHOLOGY; POLYMERS; MATRIX; RESINS AB The effect of a multifunctional reactive diluent and toughener, an epoxy-terminated polyether polyol, and amino-functionalized multi-walled carbon nanotubes (NH2-MWCNTs) on the thermo-mechanical behavior of three-phase (epoxy/polyol/NH2-MWCNTs) toughened epoxy composites was investigated. Thermo-mechanical behavior of the composites was evaluated by dynamic mechanical analysis (DMA) and thermal mechanical analysis (TMA). The addition of epoxy-terminated polyether polyol to the epoxy resin caused a slight decrease in thermo-mechanical properties of resin systems. However, the addition of a very small amount of NH2-MWCNTs into the polyol-toughened epoxy considerably increased the glass transition temperature, storage and loss moduli, damping properties and coefficient of thermal expansion (CTE) of the composites. The inclusion of the polyol in the resin system resulted in a more flexible system and a corresponding decrease in the thermo-mechanical properties. However, incorporation of a uniformly dispersed 0.3 wt.% loading of NH2-MWCNTs into the polyol-toughened epoxy composites improved the properties compared with pristine and polyol-toughened epoxy composites due to improved crosslink interactions among NH2-MWCNTs, epoxy-terminated polyol and epoxy resin. (C) 2012 Elsevier Ltd. All rights reserved. C1 [Hosur, Mahesh; Zainuddin, Shaik; Jeelani, Shaik] Tuskegee Univ, Dept Mat Sci & Engn, Tuskegee, AL 36088 USA. [Rahman, Muhammad M.; Jeelani, Shaik] Tuskegee Univ, Dept Mech Engn, Tuskegee, AL 36088 USA. [Ludwick, Adriane G.] Tuskegee Univ, Dept Chem, Tuskegee, AL 36088 USA. [Kumar, Ashok; Trovillion, Jonathan] USA, Construct Engn Res Lab, Engineer Res & Dev Ctr, Champaign, IL 61821 USA. RP Hosur, M (reprint author), Tuskegee Univ, Dept Mat Sci & Engn, Tuskegee, AL 36088 USA. EM hosur@mytu.tuskegee.edu FU ERDC-CERL; NSF-EPSCoR FX The authors would like to acknowledge ERDC-CERL and NSF-EPSCoR for funding this work. The authors also would like to thank Mr. Richard Moulton, Applied Poleramic Inc. for providing materials and Dr. Michael E. Miller at Auburn University's Research Instrumentation Facility, Auburn University, for SEM and TEM micrographs. NR 34 TC 10 Z9 10 U1 2 U2 38 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0142-9418 J9 POLYM TEST JI Polym. Test PD SEP PY 2012 VL 31 IS 6 BP 777 EP 784 DI 10.1016/j.polymertesting.2012.05.006 PG 8 WC Materials Science, Characterization & Testing; Polymer Science SC Materials Science; Polymer Science GA 990EO UT WOS:000307614000010 ER PT J AU Aldstadt, J Yoon, IK Tannitisupawong, D Jarman, RG Thomas, SJ Gibbons, RV Uppapong, A Iamsirithaworn, S Rothman, AL Scott, TW Endy, T AF Aldstadt, Jared Yoon, In-Kyu Tannitisupawong, Darunee Jarman, Richard G. Thomas, Stephen J. Gibbons, Robert V. Uppapong, Angkana Iamsirithaworn, Sopon Rothman, Alan L. Scott, Thomas W. Endy, Timothy TI Space-time analysis of hospitalised dengue patients in rural Thailand reveals important temporal intervals in the pattern of dengue virus transmission SO TROPICAL MEDICINE & INTERNATIONAL HEALTH LA English DT Article DE dengue; transmission; serial interval; space-time; clustering; Thailand ID AEDES-AEGYPTI DIPTERA; PUERTO-RICO; HAEMORRHAGIC FEVER; INFECTIOUS-DISEASE; CULICIDAE; VIREMIA; BLOOD; TEMPERATURE; ENVIRONMENT; POPULATION AB Objective To determine the temporal intervals at which spatial clustering of dengue hospitalisations occurs. Methods Space-time analysis of 262 people hospitalised and serologically confirmed with dengue virus infections in Kamphaeng Phet, Thailand was performed. The cases were observed between 1 January 2009 and 6 May 2011. Spatial coordinates of each patients home were captured using the Global Positioning System. A novel method based on the Knox test was used to determine the temporal intervals between cases at which spatial clustering occurred. These intervals are indicative of the length of time between successive illnesses in the chain of dengue virus transmission. Results The strongest spatial clustering occurred at the 1517-day interval. There was also significant spatial clustering over short intervals (25 days). The highest excess risk was observed within 200 m of a previous hospitalised case and significantly elevated risk persisted within this distance for 3234 days. Conclusions Fifteen to seventeen days are the most likely serial interval between successive dengue illnesses. This novel method relies only on passively detected, hospitalised case data with household locations and provides a useful tool for understanding region-specific and outbreak-specific dengue virus transmission dynamics. C1 [Aldstadt, Jared] SUNY Buffalo, Dept Geog, Buffalo, NY 14260 USA. [Yoon, In-Kyu; Tannitisupawong, Darunee; Gibbons, Robert V.] Armed Forces Res Inst Med Sci, Dept Virol, Bangkok 10400, Thailand. [Jarman, Richard G.; Thomas, Stephen J.] Walter Reed Army Inst Res, Viral Dis Branch, Silver Spring, MD USA. [Uppapong, Angkana] Kamphaeng Phet Prov Hosp, Dept Pediat, Minist Publ Hlth, Kamphaeng Phet, Thailand. [Iamsirithaworn, Sopon] Minist Publ Hlth, Bur Epidemiol, Nonthaburi, Thailand. [Rothman, Alan L.] Univ Rhode Isl, Inst Immunol & Informat, Providence, RI 02908 USA. [Scott, Thomas W.] Univ Calif Davis, Dept Entomol, Davis, CA 95616 USA. [Scott, Thomas W.] NIH, Fogarty Int Ctr, Bethesda, MD 20892 USA. [Endy, Timothy] SUNY Syracuse, Dept Infect Dis, Syracuse, NY USA. RP Aldstadt, J (reprint author), SUNY Buffalo, Dept Geog, Buffalo, NY 14260 USA. EM geojared@buffalo.edu RI Aldstadt, Jared/A-8508-2009 OI Aldstadt, Jared/0000-0001-9162-7439 FU National Institutes of Health [R01 GM083224, P01 AI034533]; U.S. Military Infectious Diseases Research Programme FX This research would not have been possible without the cooperation of the administration and staff of the Kamphaeng Phet Provincial Hospital, especially Dr. Kamchai Rungsimunpaiboon, Hospital Director. We would like to acknowledge the efforts of Ms. Wilaiwan Sridadeth, Ms. Rattiya Wannawong and the staff of the Kamphaeng Phet-AFRIMS Virology Research Unit for their thorough fieldwork and careful data management. This research was funded by National Institutes of Health grants R01 GM083224 and P01 AI034533 and U.S. Military Infectious Diseases Research Programme. This research benefitted from discussions with working group members in the Research and Policy for Infectious Disease Dynamics (RAPIDD) programme of the Science and Technology Directorate, Department of Homeland Security, and the Fogarty International Center, National Institutes of Health. The opinions or assertions contained herein are the private views of the authors and are not to be construed as reflecting the official views of the National Institutes of Health, the United States Army or the United States Department of Defense. NR 55 TC 14 Z9 14 U1 0 U2 14 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1360-2276 J9 TROP MED INT HEALTH JI Trop. Med. Int. Health PD SEP PY 2012 VL 17 IS 9 BP 1076 EP 1085 DI 10.1111/j.1365-3156.2012.03040.x PG 10 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 994OQ UT WOS:000307940800006 PM 22808917 ER PT J AU Rodway, GW Muza, SR AF Rodway, George W. Muza, Stephen R. TI The Bias of Medical Care-Keeping Medical Journals Free of Propaganda In Reply SO WILDERNESS & ENVIRONMENTAL MEDICINE LA English DT Letter C1 [Rodway, George W.] Univ Utah, Coll Nursing, Salt Lake City, UT 84112 USA. [Rodway, George W.] Sch Med, Salt Lake City, UT USA. [Muza, Stephen R.] USA, Environm Med Res Inst, Thermal & Mt Med Div, Natick, MA 01760 USA. RP Rodway, GW (reprint author), Univ Utah, Coll Nursing, Salt Lake City, UT 84112 USA. NR 2 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1080-6032 J9 WILD ENVIRON MED JI Wildern. Environ. Med. PD FAL PY 2012 VL 23 IS 3 BP 294 EP 295 PG 2 WC Public, Environmental & Occupational Health; Sport Sciences SC Public, Environmental & Occupational Health; Sport Sciences GA 999BR UT WOS:000308284600020 ER PT J AU Gallaway, MS Fink, DS Millikan, AM Bell, MR AF Gallaway, Michael Shayne Fink, David S. Millikan, Amy M. Bell, Michael R. TI Factors Associated With Physical Aggression Among US Army Soldiers SO AGGRESSIVE BEHAVIOR LA English DT Article DE aggression; military; deployment; combat ID POSTTRAUMATIC-STRESS-DISORDER; MENTAL-HEALTH PROBLEMS; INTIMATE PARTNER VIOLENCE; AFGHANISTAN WAR VETERANS; COMBAT VETERANS; ALCOHOL-PROBLEMS; SPOUSE ABUSE; IRAQ WAR; DEPLOYMENT; MILITARY AB There are a growing number of studies that have approximated levels of aggression and associated outcomes among combat veterans returning from Iraq and Afghanistan using brief screening assessments. However, further research to evaluate the relative role of combat exposures and overt physical behaviors is required to further elucidate potential associations between military service, combat deployment, and overt physical aggression. The purpose of the current study was to assess the prevalence of self-reported physical aggression in a sample of US Army soldiers using an adaptation of the Revised Conflict Tactics Scale (CTS2), and examine factors associated with higher levels of aggression. A population-based cross-sectional study was conducted at a single US Army Installation within a sample of active duty US Army soldiers (n = 6,128) from two large units. Anonymous surveys were collected 6 months following deployment to measure overt aggressive behaviors, posttraumatic stress disorder, anxiety, depression, traumatic brain injury, and misuse of alcohol. There were a relatively higher number of minor and severe physical overt aggressive actions reported among soldiers who previously deployed, notably highest among deployed soldiers reporting the highest levels of combat intensity. Soldiers screening positive for the misuse of alcohol were also significantly more likely to report relatively higher levels of physical aggression. This study quantified overt aggressive behaviors and associated factors, showing increasing combat exposures may result in increased physical aggression. Clinicians treating service members returning from combat may consider assessing relative levels of combat. Aggr. Behav. 38:357-367, 2012. Published 2012 Wiley Periodicals, Inc. C1 [Gallaway, Michael Shayne; Fink, David S.; Millikan, Amy M.] USA, BSHOP, Inst Publ Hlth, Publ Hlth Command, Aberdeen Proving Ground, MD 21010 USA. [Bell, Michael R.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. RP Gallaway, MS (reprint author), USA, BSHOP, Inst Publ Hlth, Publ Hlth Command, Aberdeen Proving Ground, MD 21010 USA. EM shayne.gallaway@us.army.mil OI Fink, David/0000-0003-1531-1525 NR 40 TC 11 Z9 12 U1 0 U2 16 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0096-140X J9 AGGRESSIVE BEHAV JI Aggressive Behav. PD SEP-OCT PY 2012 VL 38 IS 5 BP 357 EP 367 DI 10.1002/ab.21436 PG 11 WC Behavioral Sciences; Psychology, Multidisciplinary SC Behavioral Sciences; Psychology GA 989MP UT WOS:000307564500003 PM 22898873 ER PT J AU Holthoff, EL Marcus, LS Pellegrino, PM AF Holthoff, Ellen L. Marcus, Logan S. Pellegrino, Paul M. TI Quantum Cascade Laser Based Photoacoustic Spectroscopy for Depth Profiling Investigations of Condensed-Phase Materials SO APPLIED SPECTROSCOPY LA English DT Article DE Photoacoustic spectroscopy; Condensed phase; Depth profiling; Quantum cascade laser ID TRACE GAS-ANALYSIS; OPTOACOUSTIC SPECTROSCOPY; CHEMICAL SENSOR; LIQUIDS; SOLIDS; CAVITY; CELL AB We report on the development of a photoacoustic device for the detection of condensed-phase materials. A mid-infrared quantum cascade laser (QCL) was used for depth-profiling studies to distinguish among glycerol films and tetraethoxysilane (TEOS) films deposited on photoresist-coated silicon wafers. The QCL was continuously tunable from 1015 cm(-1) to 1240 cm(-1), allowing for collection of photoacoustic vibrational spectra for these materials. Variation of the laser pulse repetition rate allowed for identification and molecular discrimination of glycerol, TEOS, and photoresist based solely on photoacoustic spectra collected at different film depths. C1 [Holthoff, Ellen L.; Pellegrino, Paul M.] USA, Res Lab, RDRL SEE E, Adelphi, MD 20783 USA. [Marcus, Logan S.] Univ Mississippi, Natl Ctr Phys Acoust, University, MS 38677 USA. RP Holthoff, EL (reprint author), USA, Res Lab, RDRL SEE E, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM ellen.l.holthoff.civ@mail.mil NR 47 TC 6 Z9 6 U1 0 U2 11 PU SOC APPLIED SPECTROSCOPY PI FREDERICK PA 5320 SPECTRUM DRIVE SUITE C, FREDERICK, MD 21703 USA SN 0003-7028 EI 1943-3530 J9 APPL SPECTROSC JI Appl. Spectrosc. PD SEP PY 2012 VL 66 IS 9 BP 987 EP 992 DI 10.1366/12-06655 PG 6 WC Instruments & Instrumentation; Spectroscopy SC Instruments & Instrumentation; Spectroscopy GA 990AQ UT WOS:000307603800001 ER PT J AU Sausa, RC Cabalo, JB AF Sausa, Rosario C. Cabalo, Jerry B. TI The Detection of Energetic Materials by Laser Photoacoustic Overtone Spectroscopy SO APPLIED SPECTROSCOPY LA English DT Article DE TNT; RDX; CL-20; Overtone spectroscopy; Near-infrared laser radiation; Explosives; Photoacoustic; Detection ID MOLECULAR-STRUCTURE; TRACE DETECTION; HIGH EXPLOSIVES; RAMAN-SPECTRA; RDX; WAVELENGTHS; VIBRATION; RESIDUES; VAPOR; TNT AB Laser-based sensors offer high sensitivity and species selectivity with real-time capabilities for monitoring the vapors of some energetic materials. However, the extremely low vapor pressure of many solid energetic materials under ambient conditions impedes these sensors. In this paper, we report on a novel technique based on laser photoacoustic overtone spectroscopy to detect and differentiate solid 1,3,5-trinitrotoluene (TNT), 1,3,5-trinitro-1,3,5-triazacyclohexane (RDX), and 2 4,6,8,10,12-hexanitro-2,4,6,8,10,12-hexaazaisowurtzitane (CL-20) in real time at ambient conditions. A tunable, near-infrared laser excites the target compound in the spectral region between 5800 to 6100 cm(-1), and a microphone monitors the sound that they generate by non-radiative, collisional de-excitation processes. The photoacoustic signals result from first-overtone and combination absorptions of the energetic material's C-H vibrations, and the collisional processes enhance the signal at atmospheric pressure. The spectra reveal features that are unique to each measured material and these features can serve as a fingerprint for that material. We report the effects of laser energy and wavelength on signal intensity and estimate a detection limit for these compounds. C1 [Sausa, Rosario C.] USA, Res Lab, ARL RDRL WML B, Aberdeen Proving Ground, MD 21005 USA. [Cabalo, Jerry B.] Chem Biol Engn Ctr, Aberdeen Proving Ground, MD 21010 USA. RP Sausa, RC (reprint author), USA, Res Lab, ARL RDRL WML B, Aberdeen Proving Ground, MD 21005 USA. EM rosario.c.sausa.civ@mail.mil FU ARL; ECBC FX We thank Dr. Rose Pesce-Rodriguez for providing us with the energetic material samples, along with their purity analysis, and allowing us to use her photoacoustic cell. Support from both the ARL and ECBC is greatly appreciated. NR 32 TC 6 Z9 6 U1 1 U2 17 PU SOC APPLIED SPECTROSCOPY PI FREDERICK PA 5320 SPECTRUM DRIVE SUITE C, FREDERICK, MD 21703 USA SN 0003-7028 J9 APPL SPECTROSC JI Appl. Spectrosc. PD SEP PY 2012 VL 66 IS 9 BP 993 EP 998 DI 10.1366/12-06699 PG 6 WC Instruments & Instrumentation; Spectroscopy SC Instruments & Instrumentation; Spectroscopy GA 990AQ UT WOS:000307603800002 ER PT J AU Aarabi, B Harrop, JS Tator, CH Alexander, M Dettori, JR Grossman, RG Fehlings, MG Mirvis, SE Shanmuganathan, K Zacherl, KM Burau, KD Frankowski, RF Toups, E Shaffrey, CI Guest, JD Harkema, SJ Habashi, NM Andrews, P Johnson, MM Rosner, MK AF Aarabi, Bizhan Harrop, James S. Tator, Charles H. Alexander, Melvin Dettori, Joseph R. Grossman, Robert G. Fehlings, Michael G. Mirvis, Stuart E. Shanmuganathan, Kathirkamanathan Zacherl, Katie M. Burau, Keith D. Frankowski, Ralph F. Toups, Elizabeth Shaffrey, Christopher I. Guest, James D. Harkema, Susan J. Habashi, Nader M. Andrews, Penny Johnson, Michele M. Rosner, Michael K. TI Predictors of pulmonary complications in blunt traumatic spinal cord injury SO JOURNAL OF NEUROSURGERY-SPINE LA English DT Article DE pulmonary complication; spinal cord; trauma; predictor; spinal cord injury ID RESPIRATORY COMPLICATIONS; CANAL COMPROMISE; COMPRESSION; DYSFUNCTION; MANAGEMENT; CAPACITY; PATHOPHYSIOLOGY; RELIABILITY; PREVALENCE; MORTALITY AB Object. Pulmonary complications are the most common acute systemic adverse events following spinal cord injury (SCI), and contribute to morbidity, mortality, and increased length of hospital stay (LOS). Identification of factors associated with pulmonary complications would be of value in prevention and acute care management. Predictors of pulmonary complications after SCI and their effect on neurological recovery were prospectively studied between 2005 and 2009 at the 9 hospitals in the North American Clinical Trials Network (NACTN). Methods. The authors sought to address 2 specific aims: 1) define and analyze the predictors of moderate and severe pulmonary complications following SCI; and 2) investigate whether pulmonary complications negatively affected the American Spinal Injury Association (ASIA) Impairment Scale conversion rate of patients with SCI. The NACTN registry of the demographic data, neurological findings, imaging studies, and acute hospitalization duration of patients with SCI was used to analyze the incidence and severity of pulmonary complications in 109 patients with early MR imaging and long-term follow-up (mean 9.5 months). Univariate and Bayesian logistic regression analyses were used to analyze the data. Results. In this study, 86 patients were male, and the mean age was 43 years. The causes of injury were motor vehicle accidents and falls in 80 patients. The SCI segmental level was in the cervical, thoracic, and conus medullaris regions in 87. 14, and 8 patients, respectively. Sixty-four patients were neurologically motor complete at the time of admission. The authors encountered 87 complications in 51 patients: ventilator-dependent respiratory failure (26); pneumonia (25); pleural effusion (17); acute lung injury (6); lobar collapse (4); pneumothorax (4); pulmonary embolism (2); hemothorax (2), and mucus plug (1). Univariate analysis indicated associations between pulmonary complications and younger age, sports injuries, ASIA Impairment Scale grade, ascending neurological level, and lesion length on the MRI studies at admission. Bayesian logistic regression indicated a significant relationship between pulmonary complications and ASIA Impairment Scale Grades A (p = 0.0002) and B (p = 0.04) at admission. Pulmonary complications did not affect long-term conversion of ASIA Impairment Scale grades. Conclusions. The ASIA Impairment Scale grade was the fundamental clinical entity predicting pulmonary complications. Although pulmonary complications significantly increased LOS, they did not increase mortality rates and did not adversely affect the rate of conversion to a better ASIA Impairment Scale grade in patients with SCI. Maximum canal compromise, maximum spinal cord compression, and Acute Physiology and Chronic Health Evaluation II score had no relationship to pulmonary complications. (http://thejnsorg/doi/abs/10.3171/2012.4.AOSPINE1295) C1 [Aarabi, Bizhan; Alexander, Melvin; Mirvis, Stuart E.; Shanmuganathan, Kathirkamanathan; Zacherl, Katie M.; Habashi, Nader M.; Andrews, Penny] Univ Maryland, Sch Med, Dept Neurosurg, Baltimore, MD 21201 USA. [Johnson, Michele M.] Univ Texas Med Sch Houston, Mem Hermann Hosp, Dept Neurosurg, Houston, TX USA. [Grossman, Robert G.; Burau, Keith D.; Frankowski, Ralph F.; Toups, Elizabeth] Methodist Hosp, Dept Neurosurg, Houston, TX 77030 USA. [Harkema, Susan J.] Univ Louisville, Dept Neurosurg, Louisville, KY 40292 USA. [Harkema, Susan J.] Univ Louisville, Dept Rehabil, Louisville, KY 40292 USA. [Tator, Charles H.; Fehlings, Michael G.] Toronto Western Hosp, Dept Neurosurg, Toronto, ON M5T 2S8, Canada. [Shaffrey, Christopher I.] Univ Virginia Hlth Syst, Dept Neurosurg, Charlottesville, VA USA. [Harrop, James S.] Thomas Jefferson Univ, Dept Neurosurg, Philadelphia, PA 19107 USA. [Rosner, Michael K.] Walter Reed Army Med Ctr, Dept Neurosurg, Washington, DC 20307 USA. [Guest, James D.] Univ Miami, Dept Neurosurg, Coral Gables, FL 33124 USA. [Dettori, Joseph R.] Spectrum Res Inc, Olympia, WA USA. RP Aarabi, B (reprint author), Univ Maryland Med Syst, Dept Neurosurg, 22 S Greene St,S 12D, Baltimore, MD 21201 USA. EM baarabi@smail.umaryland.edu FU AO North America; Neurosurgery Research and Education Foundation; NIH; Department of Defense; NACTN FX The authors report no conflict of interest concerning the materials or methods used in this study or the findings specified in this paper. Dr. Harrop is a consultant for DePuy Spine. Dr. Shaffrey is a consultant for Medtronic, DePuy, Biomet, Globus, and NuVasive; a patent holder with Medtronic and Biomet; and receives royalties from Medtronic, fellowship support from AO North America and Neurosurgery Research and Education Foundation, and grant support from the NIH, Department of Defense, and NACTN. NR 51 TC 11 Z9 15 U1 1 U2 17 PU AMER ASSOC NEUROLOGICAL SURGEONS PI ROLLING MEADOWS PA 5550 MEADOWBROOK DRIVE, ROLLING MEADOWS, IL 60008 USA SN 1547-5654 J9 J NEUROSURG-SPINE JI J. Neurosurg.-Spine PD SEP PY 2012 VL 17 SU S BP 38 EP 45 DI 10.3171/2012.4.AOSPINE1295 PG 8 WC Clinical Neurology; Surgery SC Neurosciences & Neurology; Surgery GA 992SG UT WOS:000307799400009 PM 22985369 ER PT J AU Austin, SDW Middleton, RT Yon, R AF Austin, Sharon D. Wright Middleton, Richard T. Yon, Rachel TI The Effect of Racial Group Consciousness on the Political Participation of African Americans and Black Ethnics in Miami-Dade County, Florida SO POLITICAL RESEARCH QUARTERLY LA English DT Article DE group consciousness; black political participation; race and ethnicity ID LATINO GROUP CONSCIOUSNESS; RACE; MOBILIZATION; IMMIGRANTS; COMMONALITY; RESOURCES; IDENTITY; CHURCHES; CITY AB This research examines group consciousness among people of African descent in Miami-Dade County, Florida, and its possible impact on their political participation. Using an original survey of over one thousand respondents, the authors question whether African Americans and black ethnics (Africans, Afro-Caribbean Americans, Afro-Cuban Americans, and Haitians) possess a shared group consciousness and, if so, why. Second, does group consciousness or socioeconomic status most influence the political participation of our respondents? The authors find that these groups have a common consciousness because of their skin color, experiences with discrimination, common interests, similar ideological views, and leadership preferences. They also find that while group consciousness has more of an impact on African American political participation, socioeconomic status more heavily influences black ethnics. Last, factors such as age, gender, partisanship, religion, and second-generation citizenship also affect African American and/or black ethnic political participation. C1 [Austin, Sharon D. Wright; Yon, Rachel] Univ Florida, Gainesville, FL 32611 USA. [Middleton, Richard T.] Univ Missouri, St Louis, MO 63121 USA. [Middleton, Richard T.] St Louis Univ, Sch Law, St Louis, MO 63103 USA. [Yon, Rachel] US Mil Acad, West Point, NY 10996 USA. RP Austin, SDW (reprint author), Univ Florida, 234 Anderson Hall, Gainesville, FL 32611 USA. EM polssdw@ufl.edu NR 70 TC 1 Z9 1 U1 2 U2 21 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 1065-9129 EI 1938-274X J9 POLIT RES QUART JI Polit. Res. Q. PD SEP PY 2012 VL 65 IS 3 BP 629 EP 641 DI 10.1177/1065912911404563 PG 13 WC Political Science SC Government & Law GA 983IB UT WOS:000307111900012 ER PT J AU Keen, EF Mende, K Yun, HC Aldous, WK Wallum, TE Guymon, CH Cole, DW Crouch, HK Griffith, ME Thompson, BL Rose, JT Murray, CK AF Keen, Edward F., III Mende, Katrin Yun, Heather C. Aldous, Wade K. Wallum, Timothy E. Guymon, Charles H. Cole, David W. Crouch, Helen K. Griffith, Matthew E. Thompson, Bernadette L. Rose, Joel T. Murray, Clinton K. TI Evaluation of Potential Environmental Contamination Sources for the Presence of Multidrug-Resistant Bacteria Linked to Wound Infections in Combat Casualties SO INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY LA English DT Article ID ACINETOBACTER-BAUMANNII; DISEASES SOCIETY; USNS COMFORT; IRAQ; INJURIES; PREVENTION; COLONIZATION; EARTHQUAKE; HEALTH; RECOVERY AB OBJECTIVE. To determine whether multidrug-resistant (MDR) gram-negative organisms are present in Afghanistan or Iraq soil samples, contaminate standard deployed hospital or modular operating rooms (ORs), or aerosolize during surgical procedures. DESIGN. Active surveillance. SETTING. US military hospitals in the United States, Afghanistan, and Iraq. METHODS. Soil samples were collected from sites throughout Afghanistan and Iraq and analyzed for presence of MDR bacteria. Environmental sampling of selected newly established modular and deployed OR high-touch surfaces and equipment was performed to determine the presence of bacterial contamination. Gram-negative bacteria aerosolization during OR surgical procedures was determined by microbiological analysis of settle plate growth. RESULTS. Subsurface soil sample isolates recovered in Afghanistan and Iraq included various pansusceptible members of Enterobacteriaceae, Vibrio species, Pseudomonas species, Acinetobacter lwoffii, and coagulase-negative Staphylococcus (CNS). OR contamination studies in Afghanistan revealed 1 surface with a Micrococcus luteus. Newly established US-based modular ORs and the colocated fixed-facility ORs revealed no gram-negative bacterial contamination prior to the opening of the modular OR and 5 weeks later. Bacterial aerosolization during surgery in a deployed fixed hospital revealed a mean gram-negative bacteria colony count of 12.8 colony-forming units (CFU)/dm(2)/h (standard deviation [SD], 17.0) during surgeries and 6.5 CFU/dm(2)/h (SD, 7.5; P = .14) when the OR was not in use. CONCLUSION. This study demonstrates no significant gram-negative bacilli colonization of modular and fixed-facility ORs or dirt and no significant aerosolization of these bacilli during surgical procedures. These results lend additional support to the role of nosocomial transmission of MDR pathogens or the colonization of the patient themselves prior to injury. C1 [Murray, Clinton K.] USA, Brooke Army Med Ctr, San Antonio Mil Med Ctr, Infect Dis Serv, Ft Sam Houston, TX 78234 USA. [Mende, Katrin] Uniformed Serv Univ Hlth Sci, Infect Dis Clin Res Program, Bethesda, MD 20814 USA. [Aldous, Wade K.; Rose, Joel T.] AMEDD Army Med Dept Ctr & Sch, Ft Sam Houston, TX USA. [Wallum, Timothy E.; Guymon, Charles H.] USA, Brooke Army Med Ctr, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Cole, David W.] Blanchfield Army Community Hosp, Ft Campbell, KY USA. RP Murray, CK (reprint author), USA, Brooke Army Med Ctr, San Antonio Mil Med Ctr, Infect Dis Serv, 3551 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM clinton.murray@amedd.army.mil RI Valle, Ruben/A-7512-2013 FU Armed Forces Health Surveillance Center, including the Global Emerging Infectious System FX This work was supported by the Armed Forces Health Surveillance Center, including the Global Emerging Infectious System. NR 33 TC 8 Z9 9 U1 1 U2 9 PU UNIV CHICAGO PRESS PI CHICAGO PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA SN 0899-823X J9 INFECT CONT HOSP EP JI Infect. Control Hosp. Epidemiol. PD SEP PY 2012 VL 33 IS 9 BP 905 EP 911 DI 10.1086/667382 PG 7 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA 988EE UT WOS:000307470400007 PM 22869264 ER PT J AU van der Rhee, B Schmidt, GM Van Orden, J AF van der Rhee, Bo Schmidt, Glen M. Van Orden, Joseph TI High-end Encroachment Patterns of New Products SO JOURNAL OF PRODUCT INNOVATION MANAGEMENT LA English DT Article ID CONJOINT-ANALYSIS; DIFFUSION; SUBSTITUTION; TECHNOLOGY; ADOPTION AB Previous research describes two key ways in which a new product may encroach on an existing market. In high-end encroachment, the new product first sells to high-end customers and then diffuses down-market; in low-end encroachment, the new product enters at the low end and encroaches up-market. This paper focuses on high-end encroachment, which can further be broken down into three subtypes, which are called the immediate, the new-attribute, and the new-market forms of high-end encroachment. This paper makes three key contributions. First, it provides a sound theoretical underpinning for the three distinct subtypes of high-end encroachmenta linear reservation price curve model (LRPCM) is used to establish this theoretical foundation. Second, this paper delineates and illustrates four different ways the high-end new-market diffusion process may progress over time. These four are: (1) the traditional type, where the new product diffuses relatively slowly and methodically over time; (2) the fad scenario, where the new product opens a new market but then fizzles out after a relatively short period of high sales; (3) the rapid diffusion outcome, where the new product opens a new market and then rapidly diffuses down-market; and (4) the prolonged-niche type, where the new product purposefully restricts itself to its own niche rather than diffusing down-market. The third key contribution of this paper is to offer managerial insights into the new-market high-end encroachment process by discussing two short case studies; namely, a retrospective look at the introduction of the iPhone, and a prospective look at Tesla's challenges in growing the market for its electric car. With regard to the iPhone, it helps explain why Apple precipitously dropped the price of the iPhone by one third only 68 days after its introduction. With regard to Tesla, it discusses how Tesla must leverage the revenues that stem from its current high-end pricing power. Tesla must be able to progress down the learning curve fast enough so that it can create a virtuous cycle; a cycle in which cost reductions and technology improvements lead to price reductions and increased sales, which in turn lead to further cost reductions. At the conclusion of the paper, a step-by-step approach is offered to aid in determining which type of encroachment should be pursued and in determining how the encroachment pattern will eventually develop. The encroachment framework and the step-by-step approach are intended to help managers better assess and mitigate the risks inherent with a new product introduction. C1 [van der Rhee, Bo] Nyenrode Business Univ, Breukelen, Netherlands. [Schmidt, Glen M.] Univ Utah, David Eccles Sch Business, Salt Lake City, UT 84112 USA. [Van Orden, Joseph] W Point Mil Acad, Dept Behav Sci & Leadership, West Point, NY USA. RP van der Rhee, B (reprint author), POB 130, NL-3620 AC Breukelen, Netherlands. EM b.vdrhee@nyenrode.nl NR 33 TC 2 Z9 2 U1 5 U2 34 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0737-6782 J9 J PROD INNOVAT MANAG JI J. Prod. Innov. Manage. PD SEP PY 2012 VL 29 IS 5 BP 715 EP 733 DI 10.1111/j.1540-5885.2012.00945.x PG 19 WC Business; Engineering, Industrial; Management SC Business & Economics; Engineering GA 984BQ UT WOS:000307164000004 ER PT J AU Cope, EC Morris, DR Scrimgeour, AG Levenson, CW AF Cope, Elise C. Morris, Deborah R. Scrimgeour, Angus G. Levenson, Cathy W. TI Use of Zinc as a Treatment for Traumatic Brain Injury in the Rat: Effects on Cognitive and Behavioral Outcomes SO NEUROREHABILITATION AND NEURAL REPAIR LA English DT Article DE TBI; zinc supplementation; anhedonia; spatial memory ID HIPPOCAMPAL NEUROGENESIS; SUPPLEMENTATION; DEPRESSION; MODEL; CHELATION; DEATH AB Background. While treatments for the behavioral deficits associated with traumatic brain injury (TBI) are currently limited, animal models suggest that zinc supplementation may increase resilience to TBI. Objective. This work tests the hypothesis that zinc supplementation after TBI can be used as treatment to improve behavioral outcomes such as anxiety, depression, and learning and memory. Methods. TBI was induced by controlled cortical impact to the medial frontal cortex. After TBI, rats were fed either a zinc adequate (ZA, 30 ppm) or zinc supplemented (ZS, 180 ppm) diet. Additional rats in each dietary group (ZA or ZS) were given a single intraperitoneal (ip) injection of zinc (30 mg/kg) 1 hour following injury. Results. Brain injury resulted in significant increases in anxiety-like and depression-like behaviors as well as impairments in learning and memory. None of the zinc treatments (dietary or ip zinc) improved TBI-induced anxiety. The 2-bottle saccharin preference test for anhedonia revealed that dietary ZS also did not improve depression-like behaviors. However, dietary ZS combined with an early ip zinc injection significantly reduced anhedonia (P < .001). Dietary supplementation after injury, but not zinc injection, significantly improved (P < .05) cognitive behavior as measured by the time spent finding the hidden platform in the Morris water maze test compared with injured rats fed a ZA diet. Conclusions. These data suggest that zinc supplementation may be an effective treatment option for improving behavioral deficits such as cognitive impairment and depression following TBI. C1 [Levenson, Cathy W.] Florida State Univ, Coll Med, Tallahassee, FL 32306 USA. [Scrimgeour, Angus G.] USA, Environm Med Res Inst, Natick, MA 01760 USA. RP Levenson, CW (reprint author), Florida State Univ, Coll Med, Tallahassee, FL 32306 USA. EM cathy.levenson@med.fsu.edu FU US Army Medical Research and Material Command FX The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work is supported by the US Army Medical Research and Material Command. NR 25 TC 17 Z9 17 U1 3 U2 15 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 1545-9683 J9 NEUROREHAB NEURAL RE JI Neurorehabil. Neural Repair PD SEP PY 2012 VL 26 IS 7 BP 907 EP 913 DI 10.1177/1545968311435337 PG 7 WC Clinical Neurology; Rehabilitation SC Neurosciences & Neurology; Rehabilitation GA 981MY UT WOS:000306973700011 PM 22331212 ER PT J AU Razavi, SM Foley, DC Karaman, I Hartwig, KT Duygulu, O Kecskes, LJ Mathaudhu, SN Hammond, VH AF Razavi, S. M. Foley, D. C. Karaman, I. Hartwig, K. T. Duygulu, O. Kecskes, L. J. Mathaudhu, S. N. Hammond, V. H. TI Effect of grain size on prismatic slip in Mg-3Al-1Zn alloy SO SCRIPTA MATERIALIA LA English DT Article DE Prismatic slip; Magnesium alloys; Equal-channel angular pressing/extrusion; Grain size; Hall-Petch relation ID CHANNEL ANGULAR EXTRUSION; MAGNESIUM ALLOY; CRYSTALLOGRAPHIC TEXTURE; ROOM-TEMPERATURE; DEFORMATION; DUCTILITY; EVOLUTION; MECHANISMS; ANISOTROPY; SHEET AB The grain size of Mg-3Al-1Zn magnesium alloy was systematically varied from 33 mu m down to 350 nm, while keeping the crystallographic texture nearly constant, via multi-temperature equal-channel angular processing. Nearly the same texture allowed the activation of mostly prismatic slip in tension and thus evaluation of the effect of grain size on prismatic slip. The maximum tensile yield strength of 385 MPa and ultimate tensile strength of 455 MPa were achieved in materials with an average grain size of 350 nm, accompanied with 13% ductility. (C) 2012 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved. C1 [Razavi, S. M.; Karaman, I.; Hartwig, K. T.] Texas A&M Univ, Dept Mech Engn, College Stn, TX 77843 USA. [Foley, D. C.; Karaman, I.; Hartwig, K. T.] Texas A&M Univ, Mat Sci & Engn Grad Program, College Stn, TX 77843 USA. [Duygulu, O.] TUBITAK MRC, Mat Inst, TR-41470 Gebze, Kocaeli, Turkey. [Kecskes, L. J.; Mathaudhu, S. N.; Hammond, V. H.] USA, Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. RP Karaman, I (reprint author), Texas A&M Univ, Dept Mech Engn, College Stn, TX 77843 USA. EM ikaraman@tamu.edu RI Kecskes, Laszlo/F-6880-2014; Duygulu, Ozgur/A-9076-2015; Karaman, Ibrahim/E-7450-2010; Mathaudhu, Suveen/B-4192-2009 OI Kecskes, Laszlo/0000-0002-1342-3729; Duygulu, Ozgur/0000-0001-8646-0363; Karaman, Ibrahim/0000-0001-6461-4958; FU US Army Research Lab [W911NF-11-2-0035] FX This work was funded by the US Army Research Lab through contract W911NF-11-2-0035. NR 21 TC 24 Z9 25 U1 5 U2 34 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 1359-6462 J9 SCRIPTA MATER JI Scr. Mater. PD SEP PY 2012 VL 67 IS 5 BP 439 EP 442 DI 10.1016/j.scriptamat.2012.05.017 PG 4 WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Science & Technology - Other Topics; Materials Science; Metallurgy & Metallurgical Engineering GA 987RE UT WOS:000307434000005 ER PT J AU Bianchini, A AF Bianchini, Alessandra TI Fuzzy Representation of Pavement Condition for Efficient Pavement Management SO COMPUTER-AIDED CIVIL AND INFRASTRUCTURE ENGINEERING LA English DT Article ID FREEWAY INCIDENT DETECTION; STEEL STRUCTURES; GENETIC ALGORITHM; COST OPTIMIZATION; NEURAL-NETWORKS; MODEL AB Many government agencies and private consulting companies manage large pavement networks in terms of infrastructure condition assessment and maintenance planning. Efficient pavement management is supported by pavement management systems (PMSs), which includes models for pavement condition assessments considered valuable by agency's engineers. The objective of this article is to define a pavement condition model able to overcome surveyors subjectivity in rating distresses and thus provide meaningful pavement conditions for the agencies to employ in project planning. The article proposes a fuzzy inference model for calculating pavement condition ratio (PCR) specifically tailored on the Alabama Department of Transportation Pavement (ALDOT) guidelines and policies. Applied to several surveyors ratings, the proposed model has the ability to smooth distress extent differences among surveyors producing PCR values within acceptable range of variability. The proposed approach has the intention of not only enhancing pavement condition characterization but also to exploit the opportunity made available by automation in the collection and interpretation of pavement data which are anyway characterized by an inherent subjectivity. C1 USA, Airfields & Pavements Branch, Geotechn & Struct Lab, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Bianchini, A (reprint author), USA, Airfields & Pavements Branch, Geotechn & Struct Lab, Engineer Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM alessandra.bianchini@usace.army.mil NR 43 TC 18 Z9 18 U1 3 U2 12 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1093-9687 J9 COMPUT-AIDED CIV INF JI Comput.-Aided Civil Infrastruct. Eng. PD SEP PY 2012 VL 27 IS 8 BP 608 EP 619 DI 10.1111/j.1467-8667.2012.00758.x PG 12 WC Computer Science, Interdisciplinary Applications; Construction & Building Technology; Engineering, Civil; Transportation Science & Technology SC Computer Science; Construction & Building Technology; Engineering; Transportation GA 986KX UT WOS:000307341600004 ER PT J AU Cross, MS Zavaleta, ES Bachelet, D Brooks, ML Enquist, CAF Fleishman, E Graumlich, LJ Groves, CR Hannah, L Hansen, L Hayward, G Koopman, M Lawler, JJ Malcolm, J Nordgren, J Petersen, B Rowland, EL Scott, D Shafer, SL Shaw, MR Tabor, GM AF Cross, Molly S. Zavaleta, Erika S. Bachelet, Dominique Brooks, Marjorie L. Enquist, Carolyn A. F. Fleishman, Erica Graumlich, Lisa J. Groves, Craig R. Hannah, Lee Hansen, Lara Hayward, Greg Koopman, Marni Lawler, Joshua J. Malcolm, Jay Nordgren, John Petersen, Brian Rowland, Erika L. Scott, Daniel Shafer, Sarah L. Shaw, M. Rebecca Tabor, Gary M. TI The Adaptation for Conservation Targets (ACT) Framework: A Tool for Incorporating Climate Change into Natural Resource Management SO ENVIRONMENTAL MANAGEMENT LA English DT Article DE Adaptation; Climate change; Conservation; Decision-making; Management; Natural resources ID STRUCTURED DECISION-MAKING; WESTERN NORTH-AMERICA; BIODIVERSITY CONSERVATION; SCENARIO; CANADA; WATER AB As natural resource management agencies and conservation organizations seek guidance on responding to climate change, myriad potential actions and strategies have been proposed for increasing the long-term viability of some attributes of natural systems. Managers need practical tools for selecting among these actions and strategies to develop a tailored management approach for specific targets at a given location. We developed and present one such tool, the participatory Adaptation for Conservation Targets (ACT) framework, which considers the effects of climate change in the development of management actions for particular species, ecosystems and ecological functions. Our framework is based on the premise that effective adaptation of management to climate change can rely on local knowledge of an ecosystem and does not necessarily require detailed projections of climate change or its effects. We illustrate the ACT framework by applying it to an ecological function in the Greater Yellowstone Ecosystem (Montana, Wyoming, and Idaho, USA)-water flows in the upper Yellowstone River. We suggest that the ACT framework is a practical tool for initiating adaptation planning, and for generating and communicating specific management interventions given an increasingly altered, yet uncertain, climate. C1 [Cross, Molly S.] Wildlife Conservat Soc, Bozeman, MT 59715 USA. [Zavaleta, Erika S.] Univ Calif Santa Cruz, Dept Environm Studies, Santa Cruz, CA 95064 USA. [Bachelet, Dominique] Conservat Biol Inst, Corvallis, OR USA. [Brooks, Marjorie L.] So Illinois Univ, Dept Zool, Carbondale, IL 62901 USA. [Enquist, Carolyn A. F.] Wildlife Soc, Bethesda, MD USA. [Enquist, Carolyn A. F.] USA, Natl Phenol Network, Tucson, AZ USA. [Fleishman, Erica] Univ Calif Santa Barbara, Bren Sch Environm Sci & Management, Santa Barbara, CA 93106 USA. [Fleishman, Erica] Univ Calif Davis, John Muir Inst Environm, Davis, CA 95616 USA. [Graumlich, Lisa J.] Univ Washington, Coll Environm, Seattle, WA 98195 USA. [Groves, Craig R.] Nature Conservancy, Bozeman, MT USA. [Hannah, Lee] Conservat Int, CABS, Arlington, VA USA. [Hansen, Lara] EcoAdapt, Bainbridge Isl, WA USA. [Hayward, Greg] US Forest Serv, Rocky Mt Reg Off, Golden, CO USA. [Koopman, Marni] Geos Inst, Ashland, OR USA. [Lawler, Joshua J.] Univ Washington, Sch Environm & Forest Sci, Seattle, WA 98195 USA. [Malcolm, Jay] Univ Toronto, Fac Forestry, Toronto, ON, Canada. [Nordgren, John] Kresge Fdn, Troy, MI USA. [Petersen, Brian] Michigan State Univ, Kellogg Biol Stn, E Lansing, MI 48824 USA. [Rowland, Erika L.] Wildlife Conservat Soc, Tucson, AZ USA. [Shafer, Sarah L.] US Geol Survey, Corvallis, OR USA. [Shaw, M. Rebecca] Environm Def Fund, San Francisco, CA USA. [Tabor, Gary M.] Ctr Large Landscape Conservat, Bozeman, MT USA. RP Cross, MS (reprint author), Wildlife Conservat Soc, 301 N Willson Ave, Bozeman, MT 59715 USA. EM mcross@wcs.org RI Brooks, Marjorie/M-5692-2014 FU Henry P. Kendall Foundation; Marisla Foundation; Surdna Foundation FX We thank J. Weaver and C. Carroll for early discussions, B. Gresswell for consultation on the Yellowstone River pilot study, A. Toivola for creating Fig. 1, and C. Schwartz, C. Clifton, and several anonymous reviewers for comments that helped strengthen the manuscript. This manuscript is a product of the Climate Change and Wildlife Conservation working group affiliated with the National Center for Ecological Analysis and Synthesis, University of California, Santa Barbara, and funded by the Henry P. Kendall Foundation, the Marisla Foundation, and the Surdna Foundation. Additional support was provided to S. Shafer from the United States Geological Survey Climate and Land Use Change Research and Development Program, and to G. Hayward from the United States Department of Agriculture Forest Service. NR 55 TC 32 Z9 33 U1 8 U2 87 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0364-152X J9 ENVIRON MANAGE JI Environ. Manage. PD SEP PY 2012 VL 50 IS 3 BP 341 EP 351 DI 10.1007/s00267-012-9893-7 PG 11 WC Environmental Sciences SC Environmental Sciences & Ecology GA 985KX UT WOS:000307266100001 PM 22773068 ER PT J AU Propst, AM Thoppil, JJ Groll, JM Frattarelli, JL Robinson, RD Retzloff, MG AF Propst, A. M. Thoppil, J. J. Groll, J. M. Frattarelli, J. L. Robinson, R. D. Retzloff, M. G. TI A SINGLE PRE-OVULATORY IUI AT 12 HOURS AFTER HCG TRIGGER IS COMPARABLE TO A TRADITIONAL IUI AT 36 HOURS. SO FERTILITY AND STERILITY LA English DT Meeting Abstract CT 68th Annual Meeting of the American-Society-for-Reproductive-Medicine (ASRM) CY OCT 20-24, 2012 CL San Diego, CA SP Amer Soc Reprod Med C1 [Propst, A. M.; Thoppil, J. J.; Robinson, R. D.; Retzloff, M. G.] San Antonio Mil Med Ctr, San Antonio, TX USA. [Groll, J. M.] Wright Patterson USAF Med Ctr, Dayton, OH USA. [Frattarelli, J. L.] Tripler Army Med Ctr, Honolulu, HI 96859 USA. [Retzloff, M. G.] Keesler USAF Med Grp, Biloxi, MS USA. [Propst, A. M.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0015-0282 EI 1556-5653 J9 FERTIL STERIL JI Fertil. Steril. PD SEP PY 2012 VL 98 IS 3 SU S MA O-288 BP S85 EP S86 PG 2 WC Obstetrics & Gynecology; Reproductive Biology SC Obstetrics & Gynecology; Reproductive Biology GA V45UY UT WOS:000209842700284 ER PT J AU Chen, X Sobhy, EA Yu, ZZ Hoyos, S Silva-Martinez, J Palermo, S Sadler, BM AF Chen, Xi Sobhy, Ehab Ahmed Yu, Zhuizhuan Hoyos, Sebastian Silva-Martinez, Jose Palermo, Samuel Sadler, Brian M. TI A Sub-Nyquist Rate Compressive Sensing Data Acquisition Front-End SO IEEE JOURNAL ON EMERGING AND SELECTED TOPICS IN CIRCUITS AND SYSTEMS LA English DT Article DE Analog-to-digital converters (ADCs); compressive sensing (CS); low-power circuit; sub-Nyquist ADC; wideband front-end AB This paper presents a sub-Nyquist rate data acquisition front-end based on compressive sensing theory. The front-end randomizes a sparse input signal by mixing it with pseudo-random number sequences, followed by analog-to-digital converter sampling at sub-Nyquist rate. The signal is then reconstructed using an L1-based optimization algorithm that exploits the signal sparsity to reconstruct the signal with high fidelity. The reconstruction is based on a priori signal model information, such as a multi-tone frequency-sparse model which matches the input signal frequency support. Wideband multi-tone test signals with 4% sparsity in 5 similar to 500 MHz band were used to experimentally verify the front-end performance. Single-tone and multi-tone tests show maximum signal to noise and distortion ratios of 40 dB and 30 dB, respectively, with an equivalent sampling rate of 1 GS/s. The analog front-end was fabricated in a 90 nm complementary metal-oxide-semiconductor process and consumes 55 mW. The front-end core occupies 0.93 mm(2). C1 [Chen, Xi] Broadcom, Irvine, CA 92617 USA. [Sobhy, Ehab Ahmed] Qualcomm, San Diego, CA 92121 USA. [Yu, Zhuizhuan] Texas Instrument, Dallas, TX 75266 USA. [Hoyos, Sebastian; Silva-Martinez, Jose; Palermo, Samuel] Texas A&M Univ, Dept Elect Engn, College Stn, TX 77840 USA. [Sadler, Brian M.] Army Res Lab, Adelphi, MD 20783 USA. RP Chen, X (reprint author), Broadcom, Irvine, CA 92617 USA. EM chenx@broadcom.com NR 49 TC 15 Z9 15 U1 0 U2 3 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 2156-3357 J9 IEEE J EM SEL TOP C PD SEP PY 2012 VL 2 IS 3 BP 542 EP 551 DI 10.1109/JETCAS.2012.2221531 PG 10 WC Engineering, Electrical & Electronic SC Engineering GA V32TG UT WOS:000208972900020 ER PT J AU Forney, AJ AF Forney, Andrew J. TI CLASS UNKNOWN: Undercover Investigations of American Work and Poverty from the Progressive Era to the Present SO JOURNAL OF THE WEST LA English DT Book Review C1 [Forney, Andrew J.] US Mil Acad, Dept Hist, West Point, NY 10996 USA. RP Forney, AJ (reprint author), US Mil Acad, Dept Hist, West Point, NY 10996 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU ABC-CLIO PI SANTA BARBARA PA 130 CREMONA DR, SANTA BARBARA, CA 93117 USA SN 0022-5169 EI 1930-0115 J9 J WEST JI J. West PD FAL PY 2012 VL 51 IS 4 BP 93 EP 93 PG 1 WC History SC History GA V35UY UT WOS:000209174600030 ER PT J AU Durning, SJ Graner, J Artino, AR Pangaro, LN Beckman, T Holmboe, E Oakes, T Roy, M Riedy, G Capaldi, V Walter, R van der Vleuten, C Schuwirth, L AF Durning, Steven J. Graner, John Artino, Anthony R., Jr. Pangaro, Louis N. Beckman, Thomas Holmboe, Eric Oakes, Terrance Roy, Michael Riedy, Gerard Capaldi, Vincent Walter, Robert van der Vleuten, Cees Schuwirth, Lambert TI Using Functional Neuroimaging Combined With a Think-Aloud Protocol to Explore Clinical Reasoning Expertise in Internal Medicine SO MILITARY MEDICINE LA English DT Article AB Background: Clinical reasoning is essential to medical practice, but because it entails internal mental processes, it is difficult to assess. Functional magnetic resonance imaging (fMRI) and think-aloud protocols may improve understanding of clinical reasoning as these methods can more directly assess these processes. The objective of our study was to use a combination of fMRI and think-aloud procedures to examine fMRI correlates of a leading theoretical model in clinical reasoning based on experimental findings to date: analytic (i.e., actively comparing and contrasting diagnostic entities) and nonanalytic (i.e., pattern recognition) reasoning. We hypothesized that there would be functional neuroimaging differences between analytic and nonanalytic reasoning theory. Methods: 17 board-certified experts in internal medicine answered and reflected on validated U.S. Medical Licensing Exam and American Board of Internal Medicine multiple-choice questions (easy and difficult) during an fMRI scan. This procedure was followed by completion of a formal think-aloud procedure. Results: fMRI findings provide some support for the presence of analytic and nonanalytic reasoning systems. Statistically significant activation of prefrontal cortex distinguished answering incorrectly versus correctly (p < 0.01), whereas activation of precuneus and midtemporal gyrus distinguished not guessing from guessing (p < 0.01). Conclusions: We found limited fMRI evidence to support analytic and nonanalytic reasoning theory, as our results indicate functional differences with correct vs. incorrect answers and guessing vs. not guessing. However, our findings did not suggest one consistent fMRI activation pattern of internal medicine expertise. This model of employing fMRI correlates offers opportunities to enhance our understanding of theory, as well as improve our teaching and assessment of clinical reasoning, a key outcome of medical education. C1 [Durning, Steven J.; Graner, John; Artino, Anthony R., Jr.; Pangaro, Louis N.; Oakes, Terrance; Roy, Michael] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [Beckman, Thomas] Mayo Clin, Rochester, MN 55905 USA. [Holmboe, Eric] Amer Board Internal Med, Philadelphia, PA 19106 USA. [Riedy, Gerard; Capaldi, Vincent; Walter, Robert] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [van der Vleuten, Cees; Schuwirth, Lambert] Maastricht Univ, NL-6211 LK Maastricht, Netherlands. RP Durning, SJ (reprint author), Uniformed Serv Univ Hlth Sci, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA. OI Artino, Anthony/0000-0003-2661-7853 NR 26 TC 10 Z9 10 U1 0 U2 5 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD SEP PY 2012 VL 177 IS 9 SU S SI SI BP 72 EP 78 PG 7 WC Medicine, General & Internal SC General & Internal Medicine GA V33OD UT WOS:000209027200016 PM 23029866 ER PT J AU Dretsch, MN Coldren, RL Kelly, MP Parish, RV Russell, ML AF Dretsch, Michael N. Coldren, Rodney L. Kelly, Mark P. Parish, Robert V. Russell, Michael L. TI No Effect of Mild Nonconcussive Injury on Neurocognitive Functioning in US Army Soldiers Deployed to Iraq SO MILITARY MEDICINE LA English DT Article AB With neurocognitive testing being heavily relied on for concussion assessments in the U.S. Warfighter, there is a need to investigate the impact of nonconcussive injury on neurocognitive functioning. Objectives: To determine if a nonconcussive injury may have a negative effect on neurocognitive functioning in a deployment setting. Methods: The current study compared scores on computerized and traditional neurocognitive tests of 166 Soldiers deployed to Iraq. Performance on a battery of tests was compared between a group of healthy deployed Soldiers (n = 102) versus a group of deployed Soldiers seeking outpatient care for mild injuries not involving the head or blast exposure (n = 62). Results: The injured group's performance was not significantly lower on any of the measures administered compared to healthy Soldiers. Conclusions: The results suggest that there was no significant effect of nonconcussive injury on neurocognitive functioning. Findings lend support to feasibility of using neurocognitive tests to evaluate the effects of concussion in theater. C1 [Dretsch, Michael N.] US Army, Aeromed Res Lab, Warfighter Hlth Div, Fort Rucker, AL 36362 USA. [Coldren, Rodney L.] Uniformed Serv Univ Hlth Sci, Dept Prevent Med & Biometr, Bethesda, MD 20814 USA. [Kelly, Mark P.] Walter Reed Army Med Ctr, Dept Psychol, Washington, DC 20037 USA. [Parish, Robert V.] Landstuhl Reg Med Ctr, APO, AE 09180 USA. [Russell, Michael L.] OTSG, Rehabil & Reintegrat Div R2D, San Antonio, TX 78230 USA. RP Dretsch, MN (reprint author), US Army, Aeromed Res Lab, Warfighter Hlth Div, 6901 Farrel Rd, Fort Rucker, AL 36362 USA. FU U.S. Army Medical Research Acquisition Activity, 820 Chandler Street, Fort Detrick, MA 21702-5014 [W81XWIH-09-2-0057] FX The authors acknowledge the assistance of numerous individuals whose efforts were critical in the performance of this study. We thank SSG David Lopez and SGT Pedro Cruz of the U.S. Army Aeromedical Research Laboratory for their diligent data collection efforts and Cara Olsen, PhD of Uniformed Services University for the Health Sciences for assistance with the statistical analyses. This work was supported in part by the U.S. Army Medical Research Acquisition Activity, 820 Chandler Street, Fort Detrick, MA 21702-5014, Project W81XWIH-09-2-0057. NR 23 TC 1 Z9 1 U1 0 U2 2 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD SEP PY 2012 VL 177 IS 9 BP 1011 EP 1014 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA V33OC UT WOS:000209027100003 PM 23025128 ER PT J AU Fielden, JS AF Fielden, JoEllen Schimmels TI Review: Management of Adjustment Disorder in the Deployed Setting SO MILITARY MEDICINE LA English DT Review AB Adjustment disorder is a maladaptive response to a stressor that causes functional impairment. The contribution of deployment stress on the diagnosis and treatment of adjustment disorder has not been previously explored. Despite the high cost and commonality of adjustment disorder as a behavioral health condition diagnosed during deployment, there are few clinical trials and no standardized recommendations found in this review related to treatment of military service members in the deployed setting. This manuscript reviews the best practices for adjustment disorder management and applies these principles to create clinical guidelines and an algorithm for treatment in the deployed setting. C1 Brooke Army Med Ctr, Dept Behav Med, Ft Sam Houston, TX 78234 USA. RP Fielden, JS (reprint author), Brooke Army Med Ctr, Dept Behav Med, 4178 Petr Dr,Bldg 3528, Ft Sam Houston, TX 78234 USA. NR 43 TC 1 Z9 2 U1 1 U2 2 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD SEP PY 2012 VL 177 IS 9 BP 1022 EP 1027 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA V33OC UT WOS:000209027100005 PM 23025130 ER PT J AU Perales, R Gallaway, MS Forys-Donahue, KL Spiess, A Millikan, AM AF Perales, Rossybelle Gallaway, M. Shayne Forys-Donahue, Kelly L. Spiess, Anita Millikan, Amy M. TI Prevalence of Childhood Trauma Among US Army Soldiers With Suicidal Behavior SO MILITARY MEDICINE LA English DT Article AB In 2009, suicide was reported to be the third leading cause of death among U.S. Army personnel. The increase of suicides in the Army indicates the need for additional research to better understand the problem. Research in civilian populations found that experiencing childhood trauma increases the risk for various negative health outcomes, including suicide and suicide attempts, during adulthood. To date, there has been very little focus on pre-existing mental health before joining the service because of a lack of existing data. Participants were active duty Army Soldiers who attempted or completed suicide as identified by the Department of Defense Suicide Event Report. Among Soldiers exhibiting suicidal behavior, analyses were completed to identify significant associations with specific types of childhood trauma experienced before joining the Army. The prevalence of childhood trauma in this population was 43.3% among the suicide cases and 64.7% among the attempt cases. The most common types of childhood trauma among Soldiers were family problems and abuse. The need for further research among military populations is clear given the high prevalence of childhood trauma found among these Soldiers with suicidal behavior and the lack of complete data for this population. C1 [Perales, Rossybelle; Gallaway, M. Shayne; Forys-Donahue, Kelly L.; Spiess, Anita; Millikan, Amy M.] US Army, Inst Publ Hlth, Aberdeen Proving Ground, MD 21010 USA. RP Perales, R (reprint author), US Army, Inst Publ Hlth, 5188 Blackhawk Rd, Aberdeen Proving Ground, MD 21010 USA. NR 54 TC 6 Z9 6 U1 2 U2 7 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD SEP PY 2012 VL 177 IS 9 BP 1034 EP 1040 PG 7 WC Medicine, General & Internal SC General & Internal Medicine GA V33OC UT WOS:000209027100007 PM 23025132 ER PT J AU Kearney, SP Bluman, EM Lonergan, KT Arrington, ED Ficke, JR AF Kearney, Sean P. Bluman, Eric M. Lonergan, Keith T. Arrington, Edward D. Ficke, James R. TI Preparedness of Orthopaedic Surgeons for Modern Battlefield Surgery SO MILITARY MEDICINE LA English DT Article AB Over 220 U.S. Army orthopaedic surgeons have deployed during the Global War on Terrorism (GWOT). This study documents the orthopaedic procedures performed during the GWOT and identifies training that prepared surgeons for deployment. It reveals deficiencies in surgeons' preparedness and intends to improve predeployment training. All surgeons deployed during the GWOT from 2001 to 2007 were surveyed. Questions fit 4 general categories: deployment demographics, medical and surgical experiences, predeployment preparation, and self-perceived preparedness during deployment. Response rate was 70%. Surgeons averaged 138 adult operative cases and 26 pediatric cases per deployment. All surgeons performed irrigation and debridement, 94% external fixation, 93% amputations, 89% arthrotomies, 86% open reduction and internal fixation, and 76% soft-tissue coverage procedures. Residency and fellowship contributed most to surgeon preparedness for deployment. Surgeons generally reported high levels of preparedness, but nearly 1 in 6 reported low levels of medical, surgical and physical preparedness. More reported low levels of mental preparedness. Soft-tissue coverage was the most frequently reported surgical deficiency. This study documents the number and types of orthopaedic procedures performed during the GWOT and identifies the self-perceived preparedness deficiencies of surgeons in a combat environment. Improvements in predeployment training are needed to better prepare surgeons for managing battlefield causalities. C1 [Kearney, Sean P.] Munson Army Hlth Ctr, Ft Leavenworth, KS 66027 USA. [Bluman, Eric M.] Brigham Foot & Ankle Ctr, Boston, MA 02130 USA. [Lonergan, Keith T.] Steadman Hawkins Clin Carolinas, Greer, SC 29650 USA. [Arrington, Edward D.] Madigan Army Med Ctr, MCHJ SOP, Tacoma, WA 98431 USA. [Ficke, James R.] Brooke Army Med Ctr, Dept Orthopaed & Rehabil, Ft Sam Houston, TX 78234 USA. RP Kearney, SP (reprint author), Munson Army Hlth Ctr, 550 Pope Ave, Ft Leavenworth, KS 66027 USA. NR 13 TC 5 Z9 5 U1 0 U2 1 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD SEP PY 2012 VL 177 IS 9 BP 1058 EP 1064 PG 7 WC Medicine, General & Internal SC General & Internal Medicine GA V33OC UT WOS:000209027100010 PM 23025135 ER PT J AU Scott, SJ Feltwell, DN Knapik, JJ Barkley, CB Hauret, KG Bullock, SH Evans, RK AF Scott, Shawn J. Feltwell, David N. Knapik, Joseph J. Barkley, Colleen B. Hauret, Keith G. Bullock, Steven H. Evans, Rachel K. TI A Multiple Intervention Strategy for Reducing Femoral Neck Stress Injuries and Other Serious Overuse Injuries in US Army Basic Combat Training SO MILITARY MEDICINE LA English DT Article AB We hypothesized that the use of evidence based injury prevention strategies would lead to a reduction in the incidence of femoral neck stress injuries (FNSIs) and other serious overuse injuries in U.S. Army Basic Combat Training (BCT). An injury prevention strategy began in late 2008 that included: (1) leadership education, (2) leadership enforcement of proven methods, and (3) injury surveillance and reporting. Data on FNSI and removal from training for injury were analyzed based on the fiscal year 2006 through 2010 (n = 210,002). For men, FNSI were reduced from 13 to 20 cases/10,000 recruits per year (2006-2008) to 8 cases/10,000 recruits in 2010 (p < 0.01); for women, FNSI were reduced from 35 to 41 cases/10,000 recruits per year (2006-2008) to 18 cases/10,000 recruits per year in 2010 (p < 0.01). For men, removals from training for injury were reduced from 0.8 to 1.1 cases/100 recruits per year (2006-2008) to 0.5 cases/100 recruits in 2010 (p < 0.01); for women removal from training for injury was reduced from 2.3 to 2.4 cases/100 recruits (2006-2008) to 1.0 case/100 recruits per years in 2010 (p < 0.01). The time course of the changes suggests that following specific injury prevention methods was effective in reducing injuries. C1 [Scott, Shawn J.] Tripler Army Med Ctr, Honolulu, HI 96859 USA. [Feltwell, David N.] 171st Infantry Brigade, Fort Jackson, SC 29207 USA. [Knapik, Joseph J.; Hauret, Keith G.; Bullock, Steven H.] US Army, Inst Publ Hlth, Aberdeen Proving Ground, MD 21010 USA. [Barkley, Colleen B.] Moncrief Army Community Hosp, Fort Jackson, SC 29207 USA. [Evans, Rachel K.] Brooke Army Med Ctr, Ctr Intrepid, Ft Sam Houston, TX 78234 USA. [Evans, Rachel K.] US Army, Inst Environm Med, Natick, MA 01760 USA. RP Scott, SJ (reprint author), Tripler Army Med Ctr, 1 Jarrett White Rd, Honolulu, HI 96859 USA. NR 34 TC 5 Z9 6 U1 1 U2 4 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD SEP PY 2012 VL 177 IS 9 BP 1081 EP 1089 PG 9 WC Medicine, General & Internal SC General & Internal Medicine GA V33OC UT WOS:000209027100014 PM 23025139 ER PT J AU Colthirst, P DeNicolo, P Will, R Simecek, JW AF Colthirst, Paul DeNicolo, Philip Will, Randy Simecek, John W. TI Use of the Dental Disease Nonbattle Injury Encounter Module to Assess the Emergency Rate on an Army Military Installation Within the United States SO MILITARY MEDICINE LA English DT Article AB The objectives of this study are (1) to establish a baseline rate for dental emergencies (DE) occurring within a Brigade Combat Team (BCT) garrisoned on a military installation located in the continental United States (CONUS), and (2) to determine if differences in risk of DE are observed in soldiers of different Dental Fitness Classifications (DFC). Data concerning DE were documented by Army Dental Corps providers using CONUS Dental Disease Nonbattle Injury Emergency Encounter module of the Corporate Dental Application (CDA). The data were collected from September 1, 2011 to December 15, 2011. The number of soldiers at risk, the BCT dental readiness, the DFC of each soldier who experienced a DE, and the date of the dental visit that preceded the DE were documented from CDA. The estimated rate of 221 DE per 1,000 soldiers per year was observed. The risk of DE for DFC 3 soldiers was five times that of soldiers who were DFC 1 or 2. Assessing the DE rate of a BCT in garrison is useful for stakeholders and policymakers who must accommodate the impact of DE on mission readiness. C1 [Colthirst, Paul; DeNicolo, Philip; Will, Randy] US Army, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Simecek, John W.] Naval Med Res Unit San Antonio, Ft Sam Houston, TX 78234 USA. RP Colthirst, P (reprint author), US Army, Inst Surg Res, 3650 Chambers Pass,Bldg 3610, Ft Sam Houston, TX 78234 USA. FU United States Army Institute of Surgical 14 Research [H-11-037] FX The authors thank the staff of the Center for Army Medical Department Strategic Studies for their superb level of professionalism and analysis. This study was funded by the United States Army Institute of Surgical 14 Research (Protocol No. H-11-037). NR 13 TC 1 Z9 1 U1 0 U2 1 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD SEP PY 2012 VL 177 IS 9 BP 1100 EP 1104 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA V33OC UT WOS:000209027100017 PM 23025142 ER PT J AU Barrera, CA Finger, DA Higashida, C Hu, B Eberly, B Kallstrom, G AF Barrera, Carlos A. Finger, David A. Higashida, Cheryl Hu, Benjamin Eberly, Bardwell Kallstrom, George TI Evaluation of Two Commercial Immunoassays Used to Screen Patients for Systemic Lupus ErytheMatosus SO MILITARY MEDICINE LA English DT Article AB Diagnosing systemic lupus erythematosus (SLE) can be challenging as laboratory screening methods, although sensitive, lack specificity. The poor specificity of autoimmune testing produces more false positive results than true positive results. False positive results can cause stress to patients without autoimmune disease and require unnecessary rheumatology consultation to rule out disease. Our objective was to evaluate two screening assays to reduce the number of false positives while maintaining high sensitivity. In this study, we evaluated two immunoassays, the AtheNA Multi-Lyle II ANA System and QUANTA Lite ANA ELISA, to screen patients for SLE. All positive screening results were compared to immunoflourescent ANA testing using theHEp-2000 ANA System. A chart review was performed on all patients tested to determine clinical diagnosis of SLE. The QuantaLite ANA ELISA produced significantly more false positive results than the AtheNA Multi-Lyte II Test System when screening for SLE in our patient population. C1 [Barrera, Carlos A.; Finger, David A.; Higashida, Cheryl; Hu, Benjamin; Eberly, Bardwell; Kallstrom, George] Tripler Army Med Ctr, Honolulu, HI 96859 USA. RP Barrera, CA (reprint author), Tripler Army Med Ctr, 1 Jarrett White Rd, Honolulu, HI 96859 USA. FU Department of Pathology, Tripler Army Medical Center FX This work was funded by the Department of Pathology, Tripler Army Medical Center. NR 11 TC 0 Z9 0 U1 0 U2 0 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD SEP PY 2012 VL 177 IS 9 BP 1110 EP 1113 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA V33OC UT WOS:000209027100019 PM 23025144 ER PT J AU Casto, KL Cho, TH AF Casto, Kristen L. Cho, Timothy H. TI In-Flight Speech Intelligibility Evaluation of a Service Member With Sensorineural Hearing Loss: Case Report SO MILITARY MEDICINE LA English DT Article AB This case report describes the in-flight speech intelligibility evaluation of an aircraft crewmember with pure tone audiometric thresholds that exceed the U.S. Army's flight standards. Results of in-flight speech intelligibility testing highlight the inability to predict functional auditory abilities from pure tone audiometry and underscore the importance of conducting validated functional hearing evaluations to determine aviation fitness-for-duty. C1 [Casto, Kristen L.; Cho, Timothy H.] United States Army, Aeromed Res Lab, Ft Rucker, AL 36330 USA. RP Casto, KL (reprint author), United States Army, Aeromed Res Lab, 6901 Farrel Ave, Ft Rucker, AL 36330 USA. FU U.S. Army Medical Research and Materiel Command-Military Operational Medicine Research Program FX The authors thank Mr. John Ramiccio, CPT Chris Wingate, and SSG Bryan Shewbridge of the U.S. Army Aeromedical Research Laboratory for their piloting and crewmember expertise. This study was funded by the U.S. Army Medical Research and Materiel Command-Military Operational Medicine Research Program. NR 8 TC 0 Z9 0 U1 0 U2 0 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD SEP PY 2012 VL 177 IS 9 BP 1114 EP 1116 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA V33OC UT WOS:000209027100020 PM 23025145 ER PT J AU Fincher, RK Green, RH AF Fincher, R. Keith Green, Roland H. TI High Serum Albumin Ascites Gradient Ascites-An Atypical Presentation of Metastatic Pancreatic Cancer SO MILITARY MEDICINE LA English DT Article AB Pancreatic adenocarcinoma has less than a 5% 5-year survival rate, and metastatic disease is associated with a median survival of 4.5 months. A typical presentation often includes evidence of biliary obstruction, abdominal pain, jaundice, and weight loss. Significant ascites is not commonly seen at initial presentation and, when present, is typically associated with a low serum albumin ascites gradient (SAAG). We discuss a patient who presented with high-SAAG ascites as her initial presentation, only to be later diagnosed with metastatic pancreatic adenocarcinoma. C1 [Fincher, R. Keith; Green, Roland H.] DD Eisenhower Army Med Ctr, Ft Gordon, GA 30905 USA. RP Fincher, RK (reprint author), DD Eisenhower Army Med Ctr, Med Care Line,Bldg 300,Hosp Rd, Ft Gordon, GA 30905 USA. NR 7 TC 0 Z9 0 U1 0 U2 0 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD SEP PY 2012 VL 177 IS 9 BP 1117 EP 1118 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA V33OC UT WOS:000209027100021 PM 23025146 ER PT J AU Hexdall, EJ Butler, FK AF Hexdall, Eric J. Butler, Frank K. TI Transient vision loss at depth due to presumed barotraumatic optic neuropathy SO UNDERSEA AND HYPERBARIC MEDICINE LA English DT Article ID SPHENOID SINUS PNEUMOCELE; BLINDNESS; AMAUROSIS; PRESSURE AB Pressure-related vision loss has been reported during ascent to altitude. We report the case of an otherwise healthy diver who suffered painless, sudden-onset binocular vision loss at depth, followed by complete recovery immediately upon surfacing. We examine the dive and briefly discuss the differential diagnosis of transient vision loss in the setting of ambient pressure changes. We conclude that the diver likely suffered from sphenoid sinus barotrauma, possibly in association with dehiscence of the bony canals of the optic nerves as they travel in close proximity to the walls of the sphenoid sinus. C1 [Hexdall, Eric J.] Duke Ctr Hyperbar Med & Environm Physiol, Durham, NC USA. [Butler, Frank K.] US Army Inst Surg Res, San Antonio, TX USA. RP Hexdall, EJ (reprint author), Duke Ctr Hyperbar Med & Environm Physiol, Durham, NC USA. EM eric.hexdall@duke.edu NR 18 TC 0 Z9 0 U1 0 U2 0 PU UNDERSEA & HYPERBARIC MEDICAL SOC INC PI DURHAM PA 21 WEST COLONY PLACE, STE 280, DURHAM, NC 27705 USA SN 1066-2936 J9 UNDERSEA HYPERBAR M JI Undersea Hyperb. Med. PD SEP-OCT PY 2012 VL 39 IS 5 BP 911 EP 914 PG 4 WC Marine & Freshwater Biology; Medicine, Research & Experimental SC Marine & Freshwater Biology; Research & Experimental Medicine GA 250BS UT WOS:000326825800007 PM 23045919 ER PT J AU Moore, AD Hamilton, JB Knafl, GJ Godley, PA Carpenter, WR Bensen, JT Mohler, JL Mishel, M AF Moore, Angelo D. Hamilton, Jill B. Knafl, George J. Godley, P. A. Carpenter, William R. Bensen, Jeannette T. Mohler, James L. Mishel, Merle TI Patient Satisfaction Influenced by Interpersonal Treatment and Communication for African American Men: The North Carolina-Louisiana Prostate Cancer Project (PCaP) SO AMERICAN JOURNAL OF MENS HEALTH LA English DT Article DE interpersonal treatment; patient-provider communication; African American men; PCaP; prostate cancer ID HEALTH-CARE; PHYSICIANS COMMUNICATION; CULTURAL COMPETENCE; RACIAL DISPARITIES; BEHAVIORAL-MODEL; PERCEPTIONS; QUALITY; OUTCOMES; PARTICIPATION; INTERVENTION AB The purpose of this study was to determine if a particular set of health behaviors of health care providers and African American men (AAM) influence patient satisfaction from the AAM's perspective. This descriptive, correlational study consisted of 505 AAM in North Carolina diagnosed with prostate cancer and enrolled in the North Carolina-Louisiana Prostate Cancer Project (PCaP). Analyses consisted of bivariate analyses and multiple regression. Patient-to-provider communication, interpersonal treatment, and provider-to-patient communication accounted for 45% (p <= .0001) of the variability in patient satisfaction. Interpersonal treatment (provider focusing on the patient) explained the greatest amount (F = 313.53, R-2 = .39) of patient satisfaction. Since interpersonal treatment focuses on the patient and demonstrated to be the strongest predictor in patient satisfaction, it is noteworthy to consider the emphasis that should be placed on patient-centered care. In addition, knowing important variables positively affecting patient satisfaction provides useful information for developing appropriate interventions to improve AAM health care experiences. C1 [Moore, Angelo D.] USA, Tripler Army Med Ctr, Honolulu, HI USA. [Hamilton, Jill B.; Knafl, George J.; Mishel, Merle] Univ N Carolina, Sch Nursing, Chapel Hill, NC USA. [Godley, P. A.] Univ N Carolina, Sch Med, Chapel Hill, NC USA. [Bensen, Jeannette T.] Univ N Carolina, Dept Epidemiol, Gillings Sch Global Publ Hlth, Chapel Hill, NC USA. [Carpenter, William R.] Univ N Carolina, Gillings Sch Global Publ Hlth, Dept Hlth Policy & Management, Chapel Hill, NC USA. [Godley, P. A.; Bensen, Jeannette T.; Mohler, James L.] Univ N Carolina, Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27599 USA. [Mohler, James L.] Roswell Pk Canc Inst, Dept Urol, Buffalo, NY 14263 USA. RP Moore, AD (reprint author), 176 Dawson Rd, Wahiawa, HI 96786 USA. EM angelo.moore@us.army.mil RI Carpenter, William/E-5125-2013 NR 66 TC 5 Z9 5 U1 3 U2 8 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 1557-9883 J9 AM J MENS HEALTH JI Am. J. Mens Health PD SEP PY 2012 VL 6 IS 5 BP 409 EP 419 DI 10.1177/1557988312443695 PG 11 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 978IM UT WOS:000306734000008 PM 22833311 ER PT J AU Batra, RC Gopinath, G Zheng, JQ AF Batra, R. C. Gopinath, G. Zheng, J. Q. TI Material parameters for pressure-dependent yielding of unidirectional fiber-reinforced polymeric composites SO COMPOSITES PART B-ENGINEERING LA English DT Article DE Polymer-matrix composites (PMCs); Plastic deformation; Micromechanics; Homogenization ID SHAPE-MEMORY ALLOY; PIEZOCOMPOSITE; INCLUSIONS; BEHAVIOR; FAILURE; MATRIX AB We study elasto-plastic deformations of unidirectional fiber reinforced polymeric composites (UFPCs) with fibers assumed to deform elastically and the matrix elasto-plastically. The matrix's and hence composite's plastic deformations are analyzed by using both the pressure-independent von Mises yield surface and the pressure-dependent Drucker-Prager yield surface and the associated flow rules. In both cases the strain hardening of the matrix is considered and values of material parameters for the matrix are obtained by computing the effective stress versus the effective plastic strain curves from experimental uniaxial stress-strain curves. Values of parameters in the yield surface for the UFPC in terms of those of the matrix and the volume fraction of fibers are found by using a micromechanics approach. Wherever possible, the computed results are compared with the corresponding experimental findings available in the literature. Significant contributions of the work include providing a methodology for determining values of elasto-plastic material parameters for a UFPC from those of its constituents and their volume fractions, and giving expressions in terms of volume fractions of fibers for material parameters appearing in the yield surface of the composite. (C) 2011 Elsevier Ltd. All rights reserved. C1 [Batra, R. C.; Gopinath, G.] Virginia Polytech Inst & State Univ, Dept Engn Sci & Mech, Blacksburg, VA 24061 USA. [Zheng, J. Q.] USA, Program Execut Off Soldier, Haymarket, VA 20169 USA. RP Batra, RC (reprint author), Virginia Polytech Inst & State Univ, Dept Engn Sci & Mech, Blacksburg, VA 24061 USA. EM rbatra@vt.edu FU Army Research Laboratory; Office of Naval Research [N00014-1-06-0567]; [W911NF-06-2-0014] FX This research was sponsored by the Army Research Laboratory and was accomplished under Cooperative Agreement Number W911NF-06-2-0014. The views and conclusions contained in this document are those of the authors and should not be interpreted as representing official policies, either expressed or implied, of the Army Research Laboratory or the US Government. The US Government is authorized to reproduce and distribute reprints for Government purposes notwithstanding any copyright notation hereon. The work was also partially supported by the Office of Naval Research Grant N00014-1-06-0567 to Virginia Polytechnic Institute and State University with Dr. Y.D.S. Rajapakse as the program manager. NR 35 TC 2 Z9 2 U1 0 U2 6 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1359-8368 EI 1879-1069 J9 COMPOS PART B-ENG JI Compos. Pt. B-Eng. PD SEP PY 2012 VL 43 IS 6 SI SI BP 2594 EP 2604 DI 10.1016/j.compositesb.2011.12.005 PG 11 WC Engineering, Multidisciplinary; Materials Science, Composites SC Engineering; Materials Science GA 978EY UT WOS:000306724600008 ER PT J AU Lurchachaiwong, W Monkanna, T Leepitakrat, S Ponlawat, A Sattabongkot, J Schuster, AL McCardle, PW Richards, AL AF Lurchachaiwong, Woradee Monkanna, Taweesak Leepitakrat, Surachai Ponlawat, Alongkot Sattabongkot, Jetsumon Schuster, Anthony L. McCardle, Patrick W. Richards, Allen L. TI Variable clinical responses of a scrub typhus outbred mouse model to feeding by Orientia tsutsugamushi infected mites SO EXPERIMENTAL AND APPLIED ACAROLOGY LA English DT Article DE Scrub typhus; Orientia tsutsugamushi; Mouse model; Mites ID LEPTOTROMBIDIUM-DELIENSE; RICKETTSIA-TSUTSUGAMUSHI; ACARI-TROMBICULIDAE; LABORATORY MICE; TRANSMISSION; INOCULATION; THAILAND; IMPHALUM; CHIGGERS; FEATURES AB Rodents are the natural hosts for Leptotrombidium mites that transmit Orientia tsutsugamushi, the causative agent of scrub typhus, a potentially fatal febrile human disease. Utilizing mite lines that included O. tsutsugamushi infected and non-infected Leptotrombidium species we investigated the varied infection response of outbred mice (ICR) exposed to L. chiangraiensis (Lc), L. imphalum (Li) and L. deliense (Ld). Each of six mite lines (Lc1, Lc5, Li3, Li4, Li7 and Ld) was separately placed in the inner ears of ICR mice either as a single individual (individual feeding, IF) or as a group of 2-4 individuals (pool feeding, PF). The species of infected chigger feeding on mice significantly affected mortality rates of the mice, with mite lines of Lc causing higher mean (+/- SE) mortality (90.7 +/- A 3.6 %) than mite lines of Li (62.9 +/- A 5.6 %) or Ld (53.6 +/- A 5.8 %). Mouse responses which included time to death, food consumption and total mice weight change depended on mite species and their O. tsutsugamushi genotype, more than on feeding procedure (IF vs. PF) except for mite lines within the Lc. Infected mite lines of Lc were the most virulent infected mites assessed whereas the infected Ld species was the least virulent for the ICR. Mice killed by various mite lines showed enlarged spleens and produced ascites. The results of this investigation of the clinical responses of ICR mice to feeding by various infected mite lines indicated that the different species of infected mites and their O. tsutsugamushi genotype produced different clinical presentations in ICR mice, a scrub typhus mouse model which mimics the natural transmission of O. tsutsugamushi that is critical for understanding scrub typhus disease in terms of natural transmission, host-pathogen-vector interaction and vaccine development. C1 [Lurchachaiwong, Woradee; Monkanna, Taweesak; Leepitakrat, Surachai; Ponlawat, Alongkot; Schuster, Anthony L.; McCardle, Patrick W.] Armed Forces Res Inst Med Sci, Dept Entomol, US Army Med Component, Bangkok 10400, Thailand. [Sattabongkot, Jetsumon] Mahidol Univ, Fac Trop Med, Mahidol Vivax Res Ctr, Bangkok, Thailand. [Richards, Allen L.] USN, Med Res Ctr, Viral & Rickettsial Dis Dept, Silver Spring, MD USA. RP Lurchachaiwong, W (reprint author), Armed Forces Res Inst Med Sci, Dept Entomol, US Army Med Component, Bangkok 10400, Thailand. EM woradeel@afrims.org FU U.S. Army Medical and Material command FX We thank Drs. Kriangkrai Lerdthusnee, Stephen P. Frances, Ratree Takhumpanya and staff at department of Entomology, AFRIMS, Bangkok, Thailand, for assistance and kind support. Funding for this project was partially provided by the U.S. Army Medical and Material command. The opinions or assertions contained herein are the private views of the authors, and are not to be construed as official, or as reflecting true views of the Department of the Army, Department of the Navy or the Department of Defense. Research was conducted in compliance with the Animal Welfare Act and other federal statutes and regulations relating to animals and experiments involving animals and adheres to principles stated in the Guide for the Care and Use of Laboratory Animals, NRC Publication, 1996 edition. NR 31 TC 7 Z9 7 U1 0 U2 2 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0168-8162 J9 EXP APPL ACAROL JI Exp. Appl. Acarol. PD SEP PY 2012 VL 58 IS 1 BP 23 EP 34 DI 10.1007/s10493-012-9563-8 PG 12 WC Entomology SC Entomology GA 975XH UT WOS:000306544500003 PM 22527840 ER PT J AU Shultz, SJ Wideman, L Montgomery, MM Beasley, KN Nindl, BC AF Shultz, Sandra J. Wideman, Laurie Montgomery, Melissa M. Beasley, Kathleen N. Nindl, Bradley C. TI Changes in serum collagen markers, IGF-I, and Knee joint laxity across the menstrual cycle SO JOURNAL OF ORTHOPAEDIC RESEARCH LA English DT Article DE collagen markers; growth factors; menstrual cycle; sex hormones; knee laxity; ACL ID ANTERIOR CRUCIATE LIGAMENT; ORAL-CONTRACEPTIVE USE; CELLULAR-METABOLISM; HORMONE-LEVELS; GROWTH-FACTORS; SEX-HORMONES; YOUNG-WOMEN; INJURIES; ESTROGEN; PERFORMANCE AB Variations in serum markers of collagen production (CICP) and degradation (ICTP), insulin-like growth factor I (IGF-I) and anterior knee laxity (AKL) were measured in 20 women [10 with spontaneous cycles (eumenorrheic), 10 using oral contraceptives] over 5 consecutive days at menses (M1M5, 1st pill week), the initial estrogen rise near ovulation (O1O5, 2nd pill week), the initial progesterone rise of the early luteal phase (EL1EL5, 3rd pill week) and post-progesterone peak of the late luteal phase (LL1LL5, 4th pill week). ICTP was higher in oral contraceptive women (5.3 +/- 1.7 vs. 3.7 +/- 1.3 mu g/L; p?=?0.030), primarily during days near ovulation and the early luteal phase when concentrations decreased in eumenorrheic women (p?=?0.04). IGF-I concentrations increased during menses then decreased and remained lower during the early and late luteal phase in oral contraceptive women, resulting in lower concentrations compared to eumenorrheic women at EL2 and LL1 (p?=?0.03). CICP decreased in early and late luteal days (p?<0.01), and there was a trend toward lower concentrations in eumenorrheic versus oral contraceptive women (85.7 +/- 35.7?ng/ml vs. 123.2 +/- 49.8?ng/ml; p?=?0.07). Lower CICP and greater IGF-I concentrations predicted greater AKL across the 20 cycle days in both groups (R2?=?0.310 and 0.400). Sex hormone concentration changes across the menstrual cycle are of sufficient magnitude to influence collagen metabolism, and may indirectly influence knee structure and function. (C) 2012 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 30:14051412, 2012 C1 [Shultz, Sandra J.; Wideman, Laurie; Montgomery, Melissa M.] Univ N Carolina, Dept Kinesiol, Greensboro, NC 27402 USA. [Beasley, Kathleen N.; Nindl, Bradley C.] USA, Environm Med Res Inst, Mil Performance Div, Natick, MA 01760 USA. RP Shultz, SJ (reprint author), Univ N Carolina, Dept Kinesiol, 1408 Walker Ave, Greensboro, NC 27402 USA. EM sjshultz@uncg.edu FU NIH-NIAMS [RO3 AR 47178, R01-AR053172]; UNCG; U.S. Army Research Institute of Environmental Medicine; University of Virginia (NICHD/NIH) [U54 HD28934] FX This project was supported by NIH-NIAMS RO3 AR 47178, R01-AR053172, the UNCG Safrit Award, and cooperative agreements with the U.S. Army Research Institute of Environmental Medicine and the University of Virginia Specialized Cooperative Centers Program in Reproductive Research (NICHD/NIH U54 HD28934). NR 36 TC 6 Z9 6 U1 1 U2 5 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0736-0266 J9 J ORTHOP RES JI J. Orthop. Res. PD SEP PY 2012 VL 30 IS 9 BP 1405 EP 1412 DI 10.1002/jor.22093 PG 8 WC Orthopedics SC Orthopedics GA 972WH UT WOS:000306311400008 PM 22389002 ER PT J AU He, QG Yang, XF He, RH Bueno-Lopez, A Miller, H Ren, XM Yang, WL Koel, BE AF He, Qinggang Yang, Xiaofang He, Ruihua Bueno-Lopez, Agustin Miller, Hamish Ren, Xiaoming Yang, Wanli Koel, Bruce E. TI Electrochemical and spectroscopic study of novel Cu and Fe-based catalysts for oxygen reduction in alkaline media SO JOURNAL OF POWER SOURCES LA English DT Article DE Alkaline fuel cell; Oxygen reduction reaction; Non-noble electrocatalyst; Cu; Fe; X-ray absorption spectroscopy ID ANION-EXCHANGE MEMBRANES; CARBON-BLACK SUPPORT; PEM FUEL-CELLS; HEAT-TREATMENT; METAL PHTHALOCYANINES; DISK ELECTRODE; AREA CARBON; ACID-MEDIUM; ELECTROCATALYSTS; PERFORMANCE AB We synthesized two "single-core" Fe-N-x/C and Cu-N-x/C electrocatalysts and a bi-core CuFe-N-x/C composite electrocatalyst using iron and copper phthalocyanine-based precursors and a high-temperature pyrolysis method. The morphology, structure, and activity toward the oxygen reduction reaction (ORR) in alkaline media were evaluated for each electrocatalyst by transmission electron microscopy (TEM), X-ray Diffraction (XRD), and the rotating ring-disk electrode (RRDE) method. Although the Cu-N-x/C catalyst showed lower catalytic activity than Fe-N-x/C, the presence of Cu enhanced the ORR performance of bi-core CuFe-N-x/C, as compared to single-core Fe-N-x/C. To fully understand the synergistic effect between Cu and Fe on this enhancement, high resolution X-ray photoelectron spectroscopy (HR-XPS) and soft X-ray absorption spectroscopy (XAS) was employed to study the electronic structure of as-synthesized electrocatalysts. The HR-XPS analysis showed that metal-nitrogen bonding was maintained and that the oxidation states of Fe and Cu were influenced by the presence of the second metal in the bi-core catalyst. The XAS data revealed that a fraction of an electron was transferred from Fe to Cu, which may help to lower the kinetic barrier during the ORR process. Based on our experimental results and four different models, we briefly discuss ORR mechanisms on these metallic catalysts. Published by Elsevier B.V. C1 [He, Qinggang] Univ Calif Berkeley, Lawrence Berkeley Natl Lab, Environm Energy Technol Div, Berkeley, CA 94720 USA. [Yang, Xiaofang; Koel, Bruce E.] Princeton Univ, Dept Chem & Biol Engn, Princeton, NJ 08544 USA. [He, Ruihua; Yang, Wanli] Univ Calif Berkeley, Lawrence Berkeley Natl Lab, ALS, Berkeley, CA 94720 USA. [Bueno-Lopez, Agustin] Univ Alicante, Dept Inorgan Chem, E-03080 Alicante, Spain. [Miller, Hamish] Acta SpA, Pisa, Italy. [Ren, Xiaoming] USA, Res Lab, RDRL SED C, Adelphi, MD 20783 USA. RP He, QG (reprint author), Univ Calif Berkeley, Lawrence Berkeley Natl Lab, Environm Energy Technol Div, 1 Cyclotron Road, Berkeley, CA 94720 USA. EM hqgma2008@gmail.com RI Yang, Wanli/D-7183-2011; He, Ruihua/A-6975-2010; Yang, Xiaofang/K-4388-2012; Koel, Bruce/H-3857-2013; ren, xiaoming/F-3953-2011; He, Qinggang/O-7639-2014 OI Yang, Wanli/0000-0003-0666-8063; Koel, Bruce/0000-0002-0032-4991; MILLER, HAMISHANDREW/0000-0003-1668-6476; Bueno Lopez, Agustin/0000-0002-5434-6459; He, Qinggang/0000-0002-7693-8017 FU Office of Hydrogen, Fuel Cells and Infrastructure Technologies of the U.S. Department of Energy [DE-AC02-05CH11231]; National Science Foundation [CHE-1129417] FX This work was supported by the Assistant Secretary for Energy Efficiency and Renewable Energy, Office of Hydrogen, Fuel Cells and Infrastructure Technologies of the U.S. Department of Energy under Contract No. DE-AC02-05CH11231. BEK acknowledges support by the National Science Foundation under Grant No. CHE-1129417. NR 50 TC 36 Z9 36 U1 10 U2 135 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0378-7753 J9 J POWER SOURCES JI J. Power Sources PD SEP 1 PY 2012 VL 213 BP 169 EP 179 DI 10.1016/j.jpowsour.2012.04.029 PG 11 WC Chemistry, Physical; Electrochemistry; Energy & Fuels; Materials Science, Multidisciplinary SC Chemistry; Electrochemistry; Energy & Fuels; Materials Science GA 971ZR UT WOS:000306246800022 ER PT J AU Ruflin, J Perwich, AD Brett, C Berner, JK Lux, SM AF Ruflin, Justin Perwich, Alexander D., II Brett, Chris Berner, J. Kevin Lux, Scott M. TI Direct carbon fuel cell: A proposed hybrid design to improve commercialization potential SO JOURNAL OF POWER SOURCES LA English DT Article DE Direct carbon fuel cell; Carbon; Molten carbonate fuel cell; Solid oxide fuel cell ID OXIDATION AB This paper summarizes Contained Energy, LLC's (CEL's) 2 year work effort to produce a DCFC single cell with a minimum performance of 120 W.L-1 at 50% efficiency. It explains the challenge of high temperature that is required to get the power densities necessary to produce feasible-sized operational units and also explains problems encountered with partial oxidation of the carbon at those temperatures which causes low efficiencies. Finally, in an attempt to balance these two opposing parameters, CEL introduces a novel ceramic DCFC concept, reviews lessons learned and makes recommendations for future DCFC work. (C) 2012 Elsevier B.V. All rights reserved. C1 [Ruflin, Justin; Perwich, Alexander D., II; Brett, Chris; Berner, J. Kevin] Contained Energy LLC, Highland Hts, OH 44143 USA. [Lux, Scott M.] USA, CERL, Engineer Res & Dev Ctr, Champaign, IL 61822 USA. RP Perwich, AD (reprint author), Contained Energy LLC, 51 Alpha Pk, Highland Hts, OH 44143 USA. EM jruflin@gmail.com; aperwich@gmail.com FU Construction Engineering Research Laboratory (CERL); U.S. Army Engineer Research and Development Center [W9132T-08-C-0036]; Ohio's Third Frontier Fuel Cell Program [09-022, 09-058] FX Financial support for this work was provided by the Construction Engineering Research Laboratory (CERL), U.S. Army Engineer Research and Development Center (Contract #W9132T-08-C-0036), Ohio's Third Frontier Fuel Cell Program (Grant No. 09-022 and 09-058) and many private investors. The authors would like to thank the Wright Fuel Cell Group (Case Western Reserve University), Stark State Technical College and NASA Glenn Research Center. The authors would also like to acknowledge the contributions of Dr. Pallavi Pharkya and Dr. Abhishek Guha. NR 18 TC 14 Z9 14 U1 3 U2 31 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0378-7753 J9 J POWER SOURCES JI J. Power Sources PD SEP 1 PY 2012 VL 213 BP 275 EP 286 DI 10.1016/j.jpowsour.2012.04.048 PG 12 WC Chemistry, Physical; Electrochemistry; Energy & Fuels; Materials Science, Multidisciplinary SC Chemistry; Electrochemistry; Energy & Fuels; Materials Science GA 971ZR UT WOS:000306246800035 ER PT J AU Jobe, O Peachman, KK Matyas, GR Asher, LV Alving, CR Rao, M AF Jobe, Ousman Peachman, Kristina K. Matyas, Gary R. Asher, Ludmila V. Alving, Carl R. Rao, Mangala TI An anti-phosphoinositide-specific monoclonal antibody that neutralizes HIV-1 infection of human monocyte-derived macrophages SO VIROLOGY LA English DT Article DE Human immunodeficiency virus; Monoclonal antibody; Macrophage; Neutralization; Liposomes; Chemokines; p24; Phosphoinositide ID HUMAN-IMMUNODEFICIENCY-VIRUS; PROXIMAL EXTERNAL REGION; PLASMA-MEMBRANE; LIPID EPITOPES; PHOSPHATIDYLINOSITOL PHOSPHATE; SIMULTANEOUSLY BIND; BETA-CHEMOKINES; TYPE-1; LIPOSOMES; PROTEIN AB HIV-1 entry into cells requires the interaction of both HIV-1 envelope proteins and membrane lipids. We investigated the mechanism of neutralization of HIV-1 infection of primary monocyte-derived macrophages (MDM) by a murine monoclonal antibody (mAb) WR321. WR321 specifically binds phosphatidylinositol-4-phosphate and phosphatidylinositol-4,5-bisphosphate. These phosphoinositides are present not only on the inner surface of the plasma membranes of cells but also on the surface of virions. HIV-1 acquires these lipids during the budding process. Pre-incubation of WR321 with the virus but not with MDM neutralized HIV-1 infection of MDM. Our results demonstrate that WR321 was internalized only when it was bound to HIV-1. WR321 did not prevent the entry of HIV-1 into MDM. However, once WR321 was internalized along with HIV-1 the mAb acted intracellulary to prevent the release of virions from MDM and also triggered the release of beta-chemokines. Published by Elsevier Inc. C1 [Jobe, Ousman; Peachman, Kristina K.; Matyas, Gary R.; Asher, Ludmila V.; Alving, Carl R.; Rao, Mangala] US Mil HIV Res Program, Lab Adjuvant & Antigen Res, Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. [Jobe, Ousman; Peachman, Kristina K.; Asher, Ludmila V.] Henry M Jackson Fdn Adv Mil Med, Rockville, MD 20850 USA. RP Rao, M (reprint author), US Mil HIV Res Program, Lab Adjuvant & Antigen Res, Walter Reed Army Inst Res, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM mrao@hivresearch.org OI Matyas, Gary/0000-0002-2074-2373 FU Henry M. Jackson Foundation for the Advancement of Military Medicine [W81XWH-07-2-067]; U.S. Army Medical Research and Materiel Command [W81XWH-07-2-067] FX The authors thank Ms. Lindsay Wieczorek for growing the viral stocks. This work was supported through a Cooperative Agreement contract (no. W81XWH-07-2-067) between the Henry M. Jackson Foundation for the Advancement of Military Medicine and the U.S. Army Medical Research and Materiel Command. The views expressed in this article are those of the authors and do not reflect the official policy of the Department: of the Army, Department of Defense, or the U.S. Government. NR 32 TC 7 Z9 7 U1 0 U2 0 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0042-6822 J9 VIROLOGY JI Virology PD SEP 1 PY 2012 VL 430 IS 2 BP 110 EP 119 DI 10.1016/j.virol.2012.04.017 PG 10 WC Virology SC Virology GA 972HG UT WOS:000306267300004 PM 22633000 ER PT J AU Norton, P AF Norton, P. TI Understanding the NE Delta T of tactical infrared focal plane arrays SO OPTO-ELECTRONICS REVIEW LA English DT Article DE MWIR; LWIR; detectors; infrared AB NE Delta T is the commonly used figure-of-merit for infrared-imaging systems using focal plane arrays (FPAs). This paper discusses an intuitive approach to understanding what determines this value in the majority of MWIR and LWIR broad-band applications, namely, the available charge storage capacity of the FPA readout. This conclusion is a consequence of the negligible amount of dark current compared to photo-current for modern detector technology. C1 USA, Night Vis & Elect Sensors Directorate, Ft Belvoir, VA 22060 USA. RP Norton, P (reprint author), USA, Night Vis & Elect Sensors Directorate, Ft Belvoir, VA 22060 USA. EM p.norton@verizon.net NR 4 TC 1 Z9 2 U1 1 U2 4 PU VERSITA PI WARSAW PA SOLIPSKA 14A-1, 02-482 WARSAW, POLAND SN 1230-3402 J9 OPTO-ELECTRON REV JI Opto-Electron. Rev. PD SEP PY 2012 VL 20 IS 3 BP 275 EP 278 DI 10.2478/s11772-012-0039-5 PG 4 WC Engineering, Electrical & Electronic; Optics; Physics, Applied SC Engineering; Optics; Physics GA 969RT UT WOS:000306075400010 ER PT J AU Gopinath, G Zheng, JQ Batra, RC AF Gopinath, G. Zheng, J. Q. Batra, R. C. TI Effect of matrix on ballistic performance of soft body armor SO COMPOSITE STRUCTURES LA English DT Article DE Soft body armor; Impact; Matrix strength; Elastoplastic deformations ID FIBER-REINFORCED COMPOSITES; WOVEN-FABRIC COMPOSITES; COMPUTATIONAL ANALYSIS; IMPACT BEHAVIOR; FAILURE; MODEL; SIMULATION; ENERGY; PENETRATION; PERFORATION AB We analyze three-dimensional (3-D) deformations of soft body armor in the form of a clamped rectangular plate impacted at normal incidence by a projectile. Results have been computed by the finite element method, using the commercial software LSDYNA, for the armor with and without a matrix, and in the former case with either perfect or no bonding between the matrix and the yarn. Also, two impact speeds and two polymers, one stiffer than the other, have been considered. Significant contributions of the work include studying 3-D elastoplastic deformations, and delineating the effect of the matrix on the ballistic performance of the armor. It is found that the matrix reduces the maximum deflection of the armor, increases the size of the deformed area, and enhances the reduction in the kinetic energy of the projectile. However, the size of the deformed area is not a good indicator of the energy absorbed during impact. These results are useful for armor designers since the reduction in the maximum deflection should reduce the intensity of injuries to persons wearing the armor. On the other hand the larger deformed area of the armor can increase the possibility of injuries. (c) 2012 Elsevier Ltd. All rights reserved. C1 [Gopinath, G.; Batra, R. C.] Virginia Polytech Inst & State Univ, Dept Engn Sci & Mech, Blacksburg, VA 24061 USA. [Zheng, J. Q.] USA, Program Execut Off, Haymarket, VA 20169 USA. RP Batra, RC (reprint author), Virginia Polytech Inst & State Univ, Dept Engn Sci & Mech, M-C 0219, Blacksburg, VA 24061 USA. EM rbatra@vt.edu FU office of Naval Research Grant [N00014-05-1-0826] FX This work was supported by the office of Naval Research Grant N00014-05-1-0826 to VPI&SU. Views expressed herein are those of the authors and neither of the funding agency nor of the authors' institutions. NR 38 TC 10 Z9 10 U1 2 U2 35 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0263-8223 J9 COMPOS STRUCT JI Compos. Struct. PD SEP PY 2012 VL 94 IS 9 BP 2690 EP 2696 DI 10.1016/j.compstruct.2012.03.038 PG 7 WC Materials Science, Composites SC Materials Science GA 963DP UT WOS:000305600600003 ER PT J AU Wang, W Adali, T Emge, D AF Wang, Wei Adali, Tuelay Emge, Darren TI A Novel Approach for Target Detection and Classification Using Canonical Correlation Analysis SO JOURNAL OF SIGNAL PROCESSING SYSTEMS FOR SIGNAL IMAGE AND VIDEO TECHNOLOGY LA English DT Article DE Detection; Classification; Canonical correlation analysis ID SUBSPACE DETECTORS; MODEL AB We present a novel detection approach, detection with canonical correlation (DCC), for target detection without prior information on the interference. We use the maximum canonical correlations between the target set and the observation data set as the detection statistic, and the coefficients of the canonical vector are used to determine the indices of components from a given target library, thus enabling both detection and classification of the target components that might be present in the mixture. We derive an approximate distribution of the maximum canonical correlation when targets are present. For applications where the contributions of components are non-negative, non-negativity constraints are incorporated into the canonical correlation analysis framework and a recursive algorithm is derived to obtain the solution. We demonstrate the effectiveness of DCC and its non-negative variant by applying them on detection of surface-deposited chemical agents in Raman spectroscopy. C1 [Wang, Wei; Adali, Tuelay] Univ Maryland Baltimore Cty, Dept Comp Sci & Elect Engn, Baltimore, MD 21250 USA. [Emge, Darren] USA, Edgewood Chem & Biol Ctr, Baltimore, MD 21010 USA. RP Wang, W (reprint author), Univ Maryland Baltimore Cty, Dept Comp Sci & Elect Engn, Baltimore, MD 21250 USA. EM wangw1@umbc.edu; adali@umbc.edu; darren.emge@us.army.mil FU Edgewood Chemical and Biological Center, US Army RDECOM [W91ZLK-04-P-0950] FX This project is supported by Edgewood Chemical and Biological Center, US Army RDECOM under contract no: W91ZLK-04-P-0950. NR 22 TC 3 Z9 3 U1 0 U2 9 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1939-8018 J9 J SIGNAL PROCESS SYS JI J. Signal Process. Syst. Signal Image Video Technol. PD SEP PY 2012 VL 68 IS 3 BP 379 EP 390 DI 10.1007/s11265-011-0625-7 PG 12 WC Computer Science, Information Systems; Engineering, Electrical & Electronic SC Computer Science; Engineering GA 944NN UT WOS:000304210700007 ER PT J AU Graham, JH Duda, JJ Brown, ML Kitchen, S Emlen, JM Malol, J Bankstahl, E Krzysik, AJ Balbach, H Freeman, DC AF Graham, John H. Duda, Jeffrey J. Brown, Michelle L. Kitchen, Stanley Emlen, John M. Malol, Jagadish Bankstahl, Elizabeth Krzysik, Anthony J. Balbach, Harold Freeman, D. Carl TI The effects of drought and disturbance on the growth and developmental instability of loblolly pine (Pinus taeda L.) SO ECOLOGICAL INDICATORS LA English DT Article DE Disturbance; Loblolly pine; Drought; Indicators; Developmental instability ID FALL-LINE SANDHILLS; FLUCTUATING ASYMMETRY; IPOMOEA-PANDURATA; SOIL DISTURBANCE; RHUS-COPALLINUM; CROWN POSITION; FERTILIZATION; GEORGIA; STRESS; EVOLUTION AB Ecological indicators provide early warning of adverse environmental change, helping land managers adaptively manage their resources while minimizing costly remediation. In 1999 and 2000, we studied two such indicators, growth and developmental instability, of loblolly pine (Pinus taeda L.) influenced by mechanized infantry training at Fort Benning, Georgia. Disturbed areas were used for military training: tracked and wheeled vehicles damaged vegetation and soils. Highly disturbed sites had fewer trees, diminished ground cover, warmer soils in the summer, and more compacted soils with a shallower A-horizon. We hypothesized that disturbance would decrease the growth of needles, branches, and tree rings, increase the complexity of tree rings, and increase the developmental instability of needles. Contrary to our expectations, however, disturbance enhanced growth in the first year of the study, possibly by reducing competition. In the second year. a drought reduced growth of branches and needles, eliminating the stimulatory effect of disturbance. Growth-ring widths increased with growing-season precipitation, and decreased with growing-season temperature over the last 40 years. Disturbance had no effect on tree-ring complexity, as measured by the Hurst exponent. Within-fascicle variation of current-year needle length, a measure of developmental instability, differed among the study populations, but appeared unrelated to mechanical disturbance or drought. (C) 2012 Elsevier Ltd. All rights reserved. C1 [Graham, John H.] Berry Coll, Dept Biol, Mt Berry, GA 30149 USA. [Duda, Jeffrey J.; Emlen, John M.] US Geol Survey, Western Fisheries Res Ctr, Seattle, WA 98115 USA. [Brown, Michelle L.; Malol, Jagadish; Bankstahl, Elizabeth; Freeman, D. Carl] Wayne State Univ, Dept Biol Sci, Detroit, MI 48202 USA. [Kitchen, Stanley] US Forest Serv, USDA, Rocky Mt Res Stn, Provo, UT 84606 USA. [Krzysik, Anthony J.] Prescott Coll, Prescott, AZ 86301 USA. [Balbach, Harold] USA, ERDC CERL, Champaign, IL 61826 USA. RP Graham, JH (reprint author), Berry Coll, Dept Biol, Mt Berry, GA 30149 USA. EM jgraham@berry.edu RI Duda, Jeffrey/A-7132-2009; OI Duda, Jeffrey/0000-0001-7431-8634; Graham, John/0000-0003-1974-132X FU SERDP (Strategic Environmental Research and Development Program) [CS-1114B] FX We thank Hugh Westbury (U.S. Army ERDC-CERL) for coordinating our fieldwork at Fort Benning, and Pete Swiderek, Natural Resources Branch Chief, for his assistance in site selection, and John Brent, Environmental Management Division Chief, for research support. We also thank Lisa Ceravolo, Cathy Chamberlin-Graham, Michelle Hobig, Jennifer Murray, and Michelle Nilson for assisting with data collection. This research was funded by SERDP (Strategic Environmental Research and Development Program) Project CS-1114B, Development of Ecological Indicator Guilds for Land Management. SERDP is a joint cooperative research program of the Department of Defense, Department of Energy, and U.S. Environmental Protection Agency. These studies comply with the current laws of the United States of America. Use of trade names is for convenience of the reader and does not constitute endorsement by the U.S. government. NR 54 TC 4 Z9 4 U1 4 U2 38 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1470-160X J9 ECOL INDIC JI Ecol. Indic. PD SEP PY 2012 VL 20 BP 143 EP 150 DI 10.1016/j.ecolind.2012.03.007 PG 8 WC Biodiversity Conservation; Environmental Sciences SC Biodiversity & Conservation; Environmental Sciences & Ecology GA 939DQ UT WOS:000303788000017 ER PT J AU Stewart, B Rose, CE Tokars, JI Martin, SW Keitel, WA Keyserling, HL Babcock, J Parker, SD Jacobson, RM Poland, GA McNeil, MM AF Stewart, Brock Rose, Charles E. Tokars, Jerome I. Martin, Stacey W. Keitel, Wendy A. Keyserling, Harry L. Babcock, Janiine Parker, Scott D. Jacobson, Robert M. Poland, Gregory A. McNeil, Michael M. TI Health-related quality of life in the CDC Anthrax Vaccine Adsorbed Human Clinical Trial SO VACCINE LA English DT Article DE Quality of life; Health survey; AVA Clinical Trial ID GULF-WAR; VETERANS; MICE AB Background: After the Department of Defense implemented a mandatory anthrax vaccination program in 1998 concerns were raised about potential long-term safety effects of the current anthrax vaccine. The CDC multicenter, randomized, double-blind, placebo-controlled Anthrax Vaccine Adsorbed (AVA) Human Clinical Trial to evaluate route change and dose reduction collected data on participants' quality of life. Our objective is to assess the association between receipt of AVA and changes in health-related quality of life, as measured by the SF-36 health survey (Medical Outcomes Trust, Boston, MA), over 42 months after vaccination. Methods: 1562 trial participants completed SF-36v2 health surveys at 0, 12,18,30 and 42 months. Physical and mental summary scores were obtained from the survey results. We used Generalized Estimating Equations (GEE) analyses to assess the association between physical and mental score difference from baseline and seven study groups receiving either AVA at each dose, saline placebo at each dose, or a reduced AVA schedule substituting saline placebo for some doses. Results: Overall, mean physical and mental scores tended to decrease after baseline. However, we found no evidence that the score difference from baseline changed significantly differently between the seven study groups. Conclusions: These results do not favor an association between receipt of AVA and an altered health-related quality of life over a 42-month period. Published by Elsevier Ltd. C1 [Stewart, Brock; Tokars, Jerome I.; McNeil, Michael M.] Ctr Dis Control & Prevent, Immunizat Safety Off, Div Healthcare Qual Promot, Natl Ctr Emerging & Zoonot Infect Dis, Atlanta, GA 30333 USA. [Rose, Charles E.; Martin, Stacey W.] Ctr Dis Control & Prevent, Div Bacterial Dis, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA. [Keitel, Wendy A.] Baylor Coll Med, Houston, TX 77030 USA. [Keyserling, Harry L.] Emory Univ, Sch Med, Atlanta, GA USA. [Babcock, Janiine] Walter Reed Army Inst Res, Silver Spring, MD USA. [Parker, Scott D.] Univ Alabama Birmingham, Birmingham, AL USA. [Jacobson, Robert M.; Poland, Gregory A.] Mayo Clin, Rochester, MN USA. RP McNeil, MM (reprint author), Ctr Dis Control & Prevent, Immunizat Safety Off, Div Healthcare Qual Promot, Natl Ctr Emerging & Zoonot Infect Dis, MS D-26,1600 Clifton Rd NE, Atlanta, GA 30333 USA. EM mmm2@cdc.gov OI Jacobson, Robert/0000-0002-6355-8752 NR 20 TC 2 Z9 2 U1 0 U2 7 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X EI 1873-2518 J9 VACCINE JI Vaccine PD AUG 31 PY 2012 VL 30 IS 40 BP 5875 EP 5879 DI 10.1016/j.vaccine.2012.06.076 PG 5 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 001GY UT WOS:000308449800012 PM 22814409 ER PT J AU Defawe, OD Fong, YY Vasilyeva, E Pickett, M Carter, DK Gabriel, E Rerks-Ngarm, S Nitayaphan, S Frahm, N McElrath, MJ De Rosa, SC AF Defawe, Olivier D. Fong, Youyi Vasilyeva, Evgenia Pickett, Melissa Carter, Donald K. Gabriel, Erin Rerks-Ngarm, Supachai Nitayaphan, Sorachai Frahm, Nicole McElrath, M. Juliana De Rosa, Stephen C. TI Optimization and qualification of a multiplex bead array to assess cytokine and chemokine production by vaccine-specific cells SO JOURNAL OF IMMUNOLOGICAL METHODS LA English DT Article DE Multiplex bead array; Vaccine; HIV; Cytokine; Chemokine ID VALIDATION; RESPONSES; ASSAYS; KITS; INFECTION; BIOASSAY AB The magnitude and functional phenotype (e.g. proliferation, immune stimulation) of vaccine-induced T-cell responses are likely to be critical in defining responses that can control pathogenic challenge. Current multi-parameter flow cytometric techniques may not be sufficient to measure all of these different functions, since characterizing T-cell responses by flow cytometry is presently limited to concurrent measurement of at most 10 cytokines/chemokines. Here, we describe extensive studies conducted using standardized GCLP procedures to optimize and qualitatively/quantitatively qualify a multiplex bead array (MBA) performed on supernatant collected from stimulated peripheral blood mononuclear cells (PBMC) to assess 12 cytokines and chemokines of interest. Our optimized MBA shows good precision (intra-assay, inter-day, inter-technician; coefficients of variation <30%) and linearity for most of the analytes studied. We also developed positivity criteria that allow us to define a response as positive or negative with a high degree of confidence. In conclusion, we provide a detailed description of the qualification of an MBA, which permits quantitative and qualitative evaluation of vaccine-induced immunogenicity and analysis of immune correlates of protection. This assay provides an excellent complement to the existing repertoire of assays for assessing immunogenicity in HIV vaccine clinical trials. (C) 2012 Elsevier B.V. All rights reserved. C1 [Defawe, Olivier D.; Fong, Youyi; Vasilyeva, Evgenia; Pickett, Melissa; Carter, Donald K.; Gabriel, Erin; Frahm, Nicole; McElrath, M. Juliana; De Rosa, Stephen C.] Fred Hutchinson Canc Res Ctr, Vaccine & Infect Dis Div, Seattle, WA 98109 USA. [Rerks-Ngarm, Supachai] Minist Publ Hlth, Nonthaburi 11000, Thailand. [Nitayaphan, Sorachai] Royal Thai Army, Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Frahm, Nicole; McElrath, M. Juliana] Univ Washington, Dept Global Hlth, Seattle, WA 98195 USA. [McElrath, M. Juliana; De Rosa, Stephen C.] Univ Washington, Dept Lab Med, Seattle, WA 98195 USA. [McElrath, M. Juliana] Univ Washington, Dept Med, Seattle, WA 98195 USA. RP De Rosa, SC (reprint author), Fred Hutchinson Canc Res Ctr, Vaccine & Infect Dis Div, 1100 Fairview Ave N,LE 200,POB 19024, Seattle, WA 98109 USA. EM sderosa@fhcrc.org OI Gabriel, Erin/0000-0002-0504-8404 FU Public Health Service from the US National Institutes of Health [UM1 AI068618, UM1 AI068635, U01 AI069481]; University of Washington Center for AIDS Research, a National Institutes of Health [P30 AI027757] FX Funding was provided by Public Health Service grants UM1 AI068618, UM1 AI068635 and U01 AI069481 from the US National Institutes of Health. This work was also supported through the University of Washington Center for AIDS Research, a National Institutes of Health-funded program (P30 AI027757). We thank the James B. Pendleton Charitable Trust for their generous equipment donation, the NIH Vaccine Research Center for the provision of their HIV vaccine, the HVTN 068 protocol team, the RV144 protocol team, and all of the study participants for their time and willingness to participate in these studies. We thank Stephen Voght for scientific discussion and assistance with the preparation of the manuscript. The funders had no role in the experimental design, collection, analysis or interpretation of the data, the writing of this report, or decision to submit. NR 26 TC 13 Z9 13 U1 1 U2 6 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0022-1759 J9 J IMMUNOL METHODS JI J. Immunol. Methods PD AUG 31 PY 2012 VL 382 IS 1-2 BP 117 EP 128 DI 10.1016/j.jim.2012.05.011 PG 12 WC Biochemical Research Methods; Immunology SC Biochemistry & Molecular Biology; Immunology GA 983AN UT WOS:000307088700012 PM 22626638 ER PT J AU Stanford, SM Panchal, RG Walker, LM Wu, DJ Falk, MD Mitra, S Damle, SS Ruble, D Kaltcheva, T Zhang, S Zhang, ZY Bavari, S Barrios, AM Bottini, N AF Stanford, Stephanie M. Panchal, Rekha G. Walker, Logan M. Wu, Dennis J. Falk, Matthew D. Mitra, Sayantan Damle, Sagar S. Ruble, David Kaltcheva, Teodora Zhang, Sheng Zhang, Zhong-Yin Bavari, Sina Barrios, Amy M. Bottini, Nunzio TI High-throughput screen using a single-cell tyrosine phosphatase assay reveals biologically active inhibitors of tyrosine phosphatase CD45 SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA LA English DT Article DE single-cell assay; peptide substrate ID DRUG DISCOVERY; IN-VIVO; RECEPTOR; ACTIVATION; EXPRESSION; PEPTIDES; TARGETS; KINASE AB Many cellular signaling events are regulated by tyrosine phosphorylation and mediated by the opposing actions of protein tyrosine kinases and phosphatases. Protein tyrosine phosphatases are emerging as drug targets, but poor cell permeability of inhibitors has limited the development of drugs targeting these enzymes [Tautz L, et al. (2006) Expert Opin Ther Targets 10:157-177]. Here we developed a method to monitor tyrosine phosphatase activity at the single-cell level and applied it to the identification of cell-permeable inhibitors. The method takes advantage of the fluorogenic properties of phosphorylated coumaryl amino propionic acid (pCAP), an analog of phosphotyrosine, which can be incorporated into peptides. Once delivered into cells, pCAP peptides were dephosphorylated by protein tyrosine phosphatases, and the resulting cell fluorescence could be monitored by flow cytometry and high-content imaging. The robustness and sensitivity of the assay was validated using peptides preferentially dephosphorylated by CD45 and T-cell tyrosine phosphatase and available inhibitors of these two enzymes. The assay was applied to high-throughput screening for inhibitors of CD45, an important target for autoimmunity and infectious diseases [Hermiston ML, et al. (2003) Annu Rev Immunol 21:107-137]. We identified four CD45 inhibitors that showed activity in T cells and macrophages. These results indicate that our assay can be applied to primary screening for inhibitors of CD45 and of other protein tyrosine phosphatases to increase the yield of biologically active inhibitors. C1 [Stanford, Stephanie M.; Walker, Logan M.; Wu, Dennis J.; Falk, Matthew D.; Bottini, Nunzio] La Jolla Inst Allergy & Immunol, Div Cellular Biol, La Jolla, CA 92037 USA. [Stanford, Stephanie M.; Ruble, David; Bottini, Nunzio] Univ So Calif, Inst Med Genet, Los Angeles, CA 90033 USA. [Panchal, Rekha G.; Bavari, Sina] USA, Target Discovery & Expt Microbiol Dept, Integrated Toxicol Div, Med Res Inst Infect Dis, Frederick, MD 21702 USA. [Mitra, Sayantan; Kaltcheva, Teodora] Univ So Calif, Dept Chem, Los Angeles, CA 90089 USA. [Damle, Sagar S.] CALTECH, Div Biol, Pasadena, CA 91125 USA. [Kaltcheva, Teodora; Barrios, Amy M.] Univ Utah, Dept Med Chem, Salt Lake City, UT 84112 USA. [Zhang, Sheng; Zhang, Zhong-Yin] Indiana Univ Sch Med, Dept Biochem & Mol Biol, Indianapolis, IN 46202 USA. RP Bottini, N (reprint author), La Jolla Inst Allergy & Immunol, Div Cellular Biol, La Jolla, CA 92037 USA. EM nunzio@liai.org FU Inter-Disciplinary Zumberge grant at the University of Southern California (USC); National Institutes of Health (NIH) [DK080165, GM079386, CA126937, CA152194, CA079954]; Department of Defense Chemical Biological Defense Program through the Defense Threat Reduction Agency Transformational Medical Technologies Program [TMTI.DRUG.02.10.RD.001, TMTI0048_09_RD_T]; NIH Training Grant in Cellular, Biochemical, and Molecular Biology at USC FX We thank Krishna Kota and Robert C. Boltz for their help with high-content image analysis and Klaus Ley for critically reading the manuscript. This work was supported by an Inter-Disciplinary Zumberge grant at the University of Southern California (USC) (to N.B. and A.M.B.), by National Institutes of Health (NIH) Grants DK080165 (to N.B. and A.M.B.); GM079386 (to A.M.B.); CA126937, CA152194, and CA079954 (to Z.Y.Z.); and by the Department of Defense Chemical Biological Defense Program through the Defense Threat Reduction Agency Transformational Medical Technologies Program TMTI.DRUG.02.10.RD.001 (to R.G.P.) and TMTI0048_09_RD_T (to S.B.). S.M.S. was supported by the NIH Training Grant in Cellular, Biochemical, and Molecular Biology at USC. NR 28 TC 16 Z9 16 U1 0 U2 9 PU NATL ACAD SCIENCES PI WASHINGTON PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA SN 0027-8424 J9 P NATL ACAD SCI USA JI Proc. Natl. Acad. Sci. U. S. A. PD AUG 28 PY 2012 VL 109 IS 35 BP 13972 EP 13977 DI 10.1073/pnas.1205028109 PG 6 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 002VP UT WOS:000308565300027 PM 22891353 ER PT J AU Leary, GP Allen, JE Bunger, PL Luginbill, JB Linn, CE Macallister, IE Kavanaugh, MP Wanner, KW AF Leary, Greg P. Allen, Jean E. Bunger, Peggy L. Luginbill, Jena B. Linn, Charles E., Jr. Macallister, Irene E. Kavanaugh, Michael P. Wanner, Kevin W. TI Single mutation to a sex pheromone receptor provides adaptive specificity between closely related moth species SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA LA English DT Article DE nubilalis; furnacalis ID EUROPEAN CORN-BORER; DROSOPHILA ODORANT RECEPTORS; OSTRINIA-NUBILALIS; REPRODUCTIVE ISOLATION; OLFACTORY RECEPTORS; MOLECULAR EVOLUTION; MEMBRANE TOPOLOGY; BOMBYX-MORI; GENES; LEPIDOPTERA AB Sex pheromone communication, acting as a prezygotic barrier to mating, is believed to have contributed to the speciation of moths and butterflies in the order Lepidoptera. Five decades after the discovery of the first moth sex pheromone, little is known about the molecular mechanisms that underlie the evolution of pheromone communication between closely related species. Although Asian and European corn borers (ACB and ECB) can be interbred in the laboratory, they are behaviorally isolated from mating naturally by their responses to subtly different sex pheromone isomers, (E)-12- and (Z)-12-tetradecenyl acetate and (E)-11- and (Z)-11-tetradecenyl acetate (ACB: E12, Z12; ECB; E11, Z11). Male moth olfactory systems respond specifically to the pheromone blend produced by their conspecific females. In vitro, ECB(Z) odorant receptor 3 (OR3), a sex pheromone receptor expressed in male antennae, responds strongly to E11 but also generally to the Z11, E12, and Z12 pheromones. In contrast, we show that ACB OR3, a gene that has been subjected to positive selection (omega = 2.9), responds preferentially to the ACB E12 and Z12 pheromones. In Ostrinia species the amino acid residue corresponding to position 148 in transmembrane domain 3 of OR3 is alanine (A), except for ACB OR3 that has a threonine (T) in this position. Mutation of this residue from A to T alters the pheromone recognition pattern by selectively reducing the E11 response similar to 14-fold. These results suggest that discrete mutations that narrow the specificity of more broadly responsive sex pheromone receptors may provide a mechanism that contributes to speciation. C1 [Leary, Greg P.; Allen, Jean E.; Bunger, Peggy L.; Wanner, Kevin W.] Montana State Univ, Dept Plant Sci & Plant Pathol, Bozeman, MT 59717 USA. [Leary, Greg P.; Luginbill, Jena B.; Kavanaugh, Michael P.] Univ Montana, Dept Biomed & Pharmaceut Sci, Ctr Struct & Funct Neurosci, Missoula, MT 59812 USA. [Linn, Charles E., Jr.] Cornell Univ, Dept Entomol, New York State Agr Expt Stn, Barton Lab, Geneva, NY 14456 USA. [Macallister, Irene E.] USA, Construct Engn Res Lab, Engineer Res & Dev Ctr, Champaign, IL 61826 USA. RP Wanner, KW (reprint author), Montana State Univ, Dept Plant Sci & Plant Pathol, Bozeman, MT 59717 USA. EM kwanner@montana.edu FU US Department of Agriculture (USDA) National Institute of Food and Agriculture (NIFA) [2010-65105-20627, 2011-67012-30751]; Rocky Mountains Cooperative Ecosystem Studies Unit [W9132T-11-2-0004]; National Institutes of Health [R01 NS33270] FX We thank Tom Blake's laboratory and Li Huang's laboratory at Montana State University for the use of their equipment; and Aracely Ospina-Lopez, also of Montana State University, for excellent technical assistance. K.W.W. is supported by US Department of Agriculture (USDA) National Institute of Food and Agriculture (NIFA) Award 2010-65105-20627 and Rocky Mountains Cooperative Ecosystem Studies Unit Award W9132T-11-2-0004. G.P.L. is supported by USDA NIFA Award 2011-67012-30751. M.P.K. is supported by National Institutes of Health Award R01 NS33270. NR 53 TC 51 Z9 53 U1 8 U2 159 PU NATL ACAD SCIENCES PI WASHINGTON PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA SN 0027-8424 J9 P NATL ACAD SCI USA JI Proc. Natl. Acad. Sci. U. S. A. PD AUG 28 PY 2012 VL 109 IS 35 BP 14081 EP 14086 DI 10.1073/pnas.1204661109 PG 6 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 002VP UT WOS:000308565300046 PM 22891317 ER PT J AU Sampath, AV Zhou, QG Enck, RW McIntosh, D Shen, H Campbell, JC Wraback, M AF Sampath, A. V. Zhou, Q. G. Enck, R. W. McIntosh, D. Shen, H. Campbell, J. C. Wraback, M. TI P-type interface charge control layers for enabling GaN/SiC separate absorption and multiplication avalanche photodiodes SO APPLIED PHYSICS LETTERS LA English DT Article AB A p-type interface charge control layer (PICCL) is introduced that enables optimization of the net positive polarization induced interface charge at the GaN/SiC interface in GaN/SiC separate absorption and multiplication avalanche photodiodes (SAM-APDs) by varying its thickness. The response from SAM-APDs with PICCL thickness less than 10 nm has an anomalous shape at all bias attributed to the collection of carriers generated directly in the SiC layer. Devices with a 15 nm thick PICCL exhibit GaN related response at high bias that is indicative of punch-through of the electric field into the GaN absorption region due to optimization of the net interface charge. (C) 2012 American Institute of Physics. [http://dx.doi.org/10.1063/1.4748793] C1 [Sampath, A. V.; Enck, R. W.; Shen, H.; Wraback, M.] USA, Res Lab, Sensors & Electron Devices Directorate, RDRL SEE M, Adelphi, MD 20783 USA. [Zhou, Q. G.; McIntosh, D.; Campbell, J. C.] Univ Virginia, Dept Elect & Comp Engn, Charlottesville, VA 22904 USA. RP Sampath, AV (reprint author), USA, Res Lab, Sensors & Electron Devices Directorate, RDRL SEE M, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. RI Zhou, Qiugui/G-7357-2011 OI Zhou, Qiugui/0000-0002-7728-8765 NR 7 TC 8 Z9 9 U1 4 U2 27 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD AUG 27 PY 2012 VL 101 IS 9 AR 093506 DI 10.1063/1.4748793 PG 4 WC Physics, Applied SC Physics GA 000SI UT WOS:000308408100079 ER PT J AU Todd, CS Nasir, A Mansoor, GF Sahibzada, SM Jagodzinski, LL Salimi, F Khateri, MN Hale, BR Barthel, RV Scott, PT AF Todd, Catherine S. Nasir, Abdul Mansoor, G. Farooq Sahibzada, Sayed M. Jagodzinski, Linda L. Salimi, Farzana Khateri, M. Naim Hale, Braden R. Barthel, R. Vincent Scott, Paul T. TI Cross-sectional assessment of prevalence and correlates of blood-borne and sexually-transmitted infections among Afghan National Army recruits SO BMC INFECTIOUS DISEASES LA English DT Article DE Afghanistan; Military populations; HIV; Sexual risk behavior; Drug use ID FEMALE SEX WORKERS; HEPATITIS-B; MILITARY PERSONNEL; RISK BEHAVIORS; CONDOM USE; HIV RISK; INTERVENTION; SOLDIERS; DISEASES; TRENDS AB Background: Few data are available in Afghanistan to shape national military force health practices, particularly with regard to sexually-transmitted infections (STIs). We measured prevalence and correlates of HIV, syphilis, herpes simplex 2 virus (HSV-2), and hepatitis C virus (HCV) among Afghan National Army (ANA) recruits. Methods: A cross-sectional sample of male ANA recruits aged 18-35 years were randomly selected at the Kabul Military Training Center between February 2010 and January 2011. Participants completed an interviewer-administered questionnaire and serum-based rapid testing for syphilis and hepatitis C virus antibody on-site; HIV and HSV-2 screening, and confirmatory testing were performed off-site. Prevalence of each infection was calculated and logistic regression analysis performed to identify correlates. Results: Of 5313 recruits approached, 4750 consented to participation. Participants had a mean age of 21.8 years (SD +/- 3.8), 65.5% had lived outside Afghanistan, and 44.3% had no formal education. Few reported prior marijuana (16.3%), alcohol (5.3%), or opiate (3.4%) use. Of sexually active recruits (58.7%, N = 2786), 21.3% reported paying women for sex and 21.3% reported sex with males. Prevalence of HIV (0.063%, 95% CI: 0.013- 0.19), syphilis (0.65%, 95% CI: 0.44 - 0.93), and HCV (0.82%, 95% CI: 0.58 - 1.12) were quite low. Prevalence of HSV-2 was 3.03% (95% CI: 2.56 - 3.57), which was independently associated with age (Adjusted Odds Ratio (AOR) = 1.04, 95% CI: 1.00 - 1.09) and having a television (socioeconomic marker) (AOR = 1.46, 95% CI: 1.03 - 2.05). Conclusion: Though prevalence of HIV, HCV, syphilis, and HSV-2 was low, sexual risk behaviors and intoxicant use were present among a substantial minority, indicating need for prevention programming. Formative work is needed to determine a culturally appropriate approach for prevention programming to reduce STI risk among Afghan National Army troops. C1 [Todd, Catherine S.] Columbia Univ, Dept Obstet & Gynecol, New York, NY 10032 USA. [Nasir, Abdul; Mansoor, G. Farooq; Sahibzada, Sayed M.] Hlth Protect & Res Org, Taimany, Kabul, Afghanistan. [Jagodzinski, Linda L.] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD 20910 USA. [Salimi, Farzana] Minist Publ Hlth, Afghan Publ Hlth Inst, Kabul, Afghanistan. [Khateri, M. Naim] Minist Def, Shash Darak, Kabul, Afghanistan. [Hale, Braden R.] USN, Hlth Res Ctr, Dept Def, HIV AIDS Prevent Program, San Diego, CA 92106 USA. [Barthel, R. Vincent] US NAMRU 3, Cairo, Egypt. [Scott, Paul T.] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD 20910 USA. RP Todd, CS (reprint author), Columbia Univ, Dept Obstet & Gynecol, 622 W 168th St,PH 16-69, New York, NY 10032 USA. EM cst2121@columbia.edu FU Walter Reed Army Institute of Research FX This study was funded by the Walter Reed Army Institute of Research. Material has been reviewed by the Walter Reed Army Institute of Research. There is no objection to its presentation and/or publication. The opinions or assertions contained herein are the private views of the authors, and are not to be construed as official, or as reflecting true views of the United States Department of the Army or the Department of Defense. NR 28 TC 4 Z9 4 U1 0 U2 4 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1471-2334 J9 BMC INFECT DIS JI BMC Infect. Dis. PD AUG 21 PY 2012 VL 12 AR 196 DI 10.1186/1471-2334-12-196 PG 9 WC Infectious Diseases SC Infectious Diseases GA 027KQ UT WOS:000310351500001 PM 22909128 ER PT J AU AbdulHameed, MD Wallqvist, A Tawa, GJ AF AbdulHameed, Mohamed D. Wallqvist, Anders Tawa, Gregory J. TI Application of computational target fishing approaches in drug repurposing SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 244th National Fall Meeting of the American-Chemical-Society (ACS) CY AUG 19-23, 2012 CL Philadelphia, PA SP Amer Chem Soc, Div Hist Chem, Amer Chem Soc C1 [AbdulHameed, Mohamed D.; Wallqvist, Anders; Tawa, Gregory J.] US Army Med Res & Mat Command, Computat Drug Design Grp, DoD Biotechnol High Performance Comp Software App, Frederick, MD 21702 USA. EM mabdulhameed@bhsai.org RI AbdulHameed, Mohamed Diwan M/O-3088-2015 OI AbdulHameed, Mohamed Diwan M/0000-0003-1483-4084 NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 19 PY 2012 VL 244 MA 28-CINF PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA 220XX UT WOS:000324621802110 ER PT J AU Becker, J McElhinny, S AF Becker, Jennifer McElhinny, Stephanie TI Bio/abio research at the US Army Research Office SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 244th National Fall Meeting of the American-Chemical-Society (ACS) CY AUG 19-23, 2012 CL Philadelphia, PA SP Amer Chem Soc, Div Hist Chem, Amer Chem Soc C1 [Becker, Jennifer; McElhinny, Stephanie] US Army Res Off, Res Triangle Pk, NC 27709 USA. EM jennifer.j.becker.civ@mail.mil NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 19 PY 2012 VL 244 MA 534-COLL PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA 220XX UT WOS:000324621802713 ER PT J AU Chantawansri, TL Sliozberg, YR Andzelm, JW Hsieh, AJ AF Chantawansri, Tanya L. Sliozberg, Yelena R. Andzelm, Jan W. Hsieh, Alex J. TI High strain-rate mechanical deformation via coarse grain modeling for select model poly(urethane urea) elastomers SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 244th National Fall Meeting of the American-Chemical-Society (ACS) CY AUG 19-23, 2012 CL Philadelphia, PA SP Amer Chem Soc, Div Hist Chem, Amer Chem Soc C1 [Chantawansri, Tanya L.; Sliozberg, Yelena R.; Andzelm, Jan W.; Hsieh, Alex J.] US Army Res Lab, Macromol Sci & Technol Branch, Aberdeen Proving Ground, MD 21005 USA. EM tanya.chantawansri.civ@mail.mil RI Chantawansri, Tanya/N-3601-2013 NR 0 TC 0 Z9 0 U1 0 U2 2 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 19 PY 2012 VL 244 MA 304-POLY PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA 220XX UT WOS:000324621808463 ER PT J AU Cresce, A Borodin, O Xu, K AF Cresce, Arthur Borodin, Oleg Xu, Kang TI Investigating electrolyte/electrode interphases in Li ion batteries SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 244th National Fall Meeting of the American-Chemical-Society (ACS) CY AUG 19-23, 2012 CL Philadelphia, PA SP Amer Chem Soc, Div Hist Chem, Amer Chem Soc C1 [Cresce, Arthur; Borodin, Oleg; Xu, Kang] US Army Res Lab, Electrochem Branch, Adelphi, MD 20783 USA. EM conrad.k.xu.civ@mail.mil RI Borodin, Oleg/B-6855-2012 OI Borodin, Oleg/0000-0002-9428-5291 NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 19 PY 2012 VL 244 MA 664-ENFL PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA 220XX UT WOS:000324621804201 ER PT J AU DeLacy, BG Soljacic, M Qiu, WJ AF DeLacy, Brendan G. Soljacic, Marin Qiu, Wenjun TI Plasmon-exciton coupling in double-shell nanostructures: Investigating the effect of spacer layer composition SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 244th National Fall Meeting of the American-Chemical-Society (ACS) CY AUG 19-23, 2012 CL Philadelphia, PA SP Amer Chem Soc, Div Hist Chem, Amer Chem Soc C1 [DeLacy, Brendan G.] US Army Edgewood Chem Biol Ctr, Res & Technol Directorate, Aberdeen Proving Ground, MD 21010 USA. [Soljacic, Marin; Qiu, Wenjun] MIT, Dept Phys, Cambridge, MA 02139 USA. EM brendan.g.delacy.civ@mail.mil NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 19 PY 2012 VL 244 MA 234-COLL PG 2 WC Chemistry, Multidisciplinary SC Chemistry GA 220XX UT WOS:000324621802432 ER PT J AU Eng, G Song, XQ Hoerner, J Anjorin, C Hernandez, JD Mclean, DP Murphy, J Zapata, A AF Eng, George Song, Xueqing Hoerner, Jana Anjorin, Chezaray Hernandez, Jose D. Mclean, Diane P. Murphy, Jittawadee Zapata, Alejandra TI Synthesis, structural determination, and larvicidal effects of two series of ionic dialkylamine triphenyltin complexes against Anopheles stephensi larvae SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 244th National Fall Meeting of the American-Chemical-Society (ACS) CY AUG 19-23, 2012 CL Philadelphia, PA SP Amer Chem Soc, Div Hist Chem, Amer Chem Soc C1 [Eng, George; Song, Xueqing; Hoerner, Jana; Anjorin, Chezaray; Hernandez, Jose D.; Mclean, Diane P.] Univ Dist Columbia, Washington, DC 20008 USA. [Murphy, Jittawadee; Zapata, Alejandra] Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. EM Geng@udc.edu NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 19 PY 2012 VL 244 MA 510-INOR PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA 220XX UT WOS:000324621805356 ER PT J AU Filocamo, S Stote, R Narsimhan, G Wu, XY AF Filocamo, Shaun Stote, Robert Narsimhan, Ganesan Wu, Xiaoyu TI Biomimetic formation of metal oxides to impart multifunctionality SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 244th National Fall Meeting of the American-Chemical-Society (ACS) CY AUG 19-23, 2012 CL Philadelphia, PA SP Amer Chem Soc, Div Hist Chem, Amer Chem Soc C1 [Filocamo, Shaun; Stote, Robert] USA, Natick Soldier Res Dev & Engn Ctr, Biol Sci & Technol Team, Natick, MA 01760 USA. [Narsimhan, Ganesan; Wu, Xiaoyu] Purdue Univ, W Lafayette, IN 47907 USA. EM shaun.filocamo@us.army.mil NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 19 PY 2012 VL 244 MA 477-COLL PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA 220XX UT WOS:000324621802658 ER PT J AU Fischel, JS Fischel, MH Lafferty, BJ Sparks, DL AF Fischel, Jason S. Fischel, Matthew H. Lafferty, Brandon J. Sparks, Donald L. TI Arsenic mobilization in the critical zone: Oxidation by manganese oxide minerals SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 244th National Fall Meeting of the American-Chemical-Society (ACS) CY AUG 19-23, 2012 CL Philadelphia, PA SP Amer Chem Soc, Div Hist Chem, Amer Chem Soc C1 [Fischel, Jason S.; Fischel, Matthew H.; Sparks, Donald L.] Univ Delaware, Dept Plant & Soil Sci, Newark, DE 19716 USA. [Fischel, Jason S.; Fischel, Matthew H.; Sparks, Donald L.] Univ Delaware, Ctr Crit Zone Res, Newark, DE 19716 USA. [Lafferty, Brandon J.] US Army Corps Engineers, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. EM fischelj@udel.edu NR 0 TC 0 Z9 0 U1 1 U2 2 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 19 PY 2012 VL 244 MA 261-ENVR PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA 220XX UT WOS:000324621804472 ER PT J AU Flanigan, PM Radell, LL Brady, JJ Levis, RJ AF Flanigan, Paul M. Radell, Laine L. Brady, John J. Levis, Robert J. TI Differentiation of eight phenotypes and discovery of potential biomarkers for a single tissue class using laser electrospray mass spectrometry and multivariate statistical analysis SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 244th National Fall Meeting of the American-Chemical-Society (ACS) CY AUG 19-23, 2012 CL Philadelphia, PA SP Amer Chem Soc, Div Hist Chem, Amer Chem Soc C1 [Flanigan, Paul M.; Radell, Laine L.; Levis, Robert J.] Temple Univ, Philadelphia, PA 19122 USA. [Brady, John J.] US Army Res Lab, Adelphi, MD 20783 USA. EM paul.flanigan@temple.edu NR 0 TC 0 Z9 0 U1 0 U2 4 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 19 PY 2012 VL 244 MA 48-ANYL PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA 220XX UT WOS:000324621800825 ER PT J AU Griggs, CS Barber, PS Kelley, SP Gurau, G Rogers, RD AF Griggs, Chris S. Barber, Patrick S. Kelley, Steven P. Gurau, Gabriela Rogers, Robin D. TI Electrospun chitin nanofibers for uranyl absorbant materials SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 244th National Fall Meeting of the American-Chemical-Society (ACS) CY AUG 19-23, 2012 CL Philadelphia, PA SP Amer Chem Soc, Div Hist Chem, Amer Chem Soc C1 [Griggs, Chris S.; Barber, Patrick S.; Kelley, Steven P.; Gurau, Gabriela; Rogers, Robin D.] Univ Alabama, Dept Chem, Tuscaloosa, AL 35487 USA. [Griggs, Chris S.] US Army Engineer Res & Dev Ctr, Dept Environm Engn, Vicksburg, MS 39180 USA. EM csgriggs@crimson.ua.edu NR 0 TC 0 Z9 0 U1 0 U2 3 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 19 PY 2012 VL 244 MA 58-IEC PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA 220XX UT WOS:000324621804689 ER PT J AU Hogan, M Bahta, M Zhao, B Cherry, S Tropea, JE Lountos, GT Burke, TR Waugh, DS Ulrich, RG AF Hogan, Megan Bahta, Medhanit Zhao, Bryan Cherry, Scott Tropea, Joseph E. Lountos, George T. Burke, Terrence R. Waugh, David S. Ulrich, Robert G. TI Investigation of the interaction kinetics between small molecule inhibitors and the protein tyrosine phosphatase YopH from Yersinia pestis SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 244th National Fall Meeting of the American-Chemical-Society (ACS) CY AUG 19-23, 2012 CL Philadelphia, PA SP Amer Chem Soc, Div Hist Chem, Amer Chem Soc C1 [Hogan, Megan; Zhao, Bryan] Oak Ridge Associated Univ, Fac Res Participat Program, Belcamp, MD 21017 USA. [Hogan, Megan; Zhao, Bryan; Ulrich, Robert G.] US Army Med Res Inst Infect Dis, Lab Mol Immunol, Frederick, MD 21702 USA. [Bahta, Medhanit; Burke, Terrence R.] NCI, Biol Chem Lab, Ctr Canc Res, NIH,Frederick Natl Lab, Frederick, MD 21702 USA. [Cherry, Scott; Tropea, Joseph E.; Lountos, George T.; Waugh, David S.] NCI, Macromol Crystallog Lab, Ctr Canc Res, NIH,Frederick Natl Lab, Frederick, MD 21702 USA. RI Lountos, George/B-3983-2015 NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 19 PY 2012 VL 244 MA 402-MEDI PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA 220XX UT WOS:000324621806124 ER PT J AU Jackson, AC Price, SC Beyer, FL AF Jackson, Aaron C. Price, Samuel C. Beyer, Frederick L. TI Bis(benzimidazoyl)-4-oxypyridine-functionalized silica for metallopolymer nanocomposites SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 244th National Fall Meeting of the American-Chemical-Society (ACS) CY AUG 19-23, 2012 CL Philadelphia, PA SP Amer Chem Soc, Div Hist Chem, Amer Chem Soc C1 [Jackson, Aaron C.; Price, Samuel C.; Beyer, Frederick L.] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. EM aaron.jackson57.ctr@mail.mil NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 19 PY 2012 VL 244 MA 236-PMSE PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA 220XX UT WOS:000324621808005 ER PT J AU Jenkins, AL Balboa, A Hurley, MM Karwacki, CJ AF Jenkins, Amanda L. Balboa, Alex Hurley, Margaret M. Karwacki, Christopher J. TI Preparation, properties, and modeling of luminescent lanthanide labeled graphene-oxide SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 244th National Fall Meeting of the American-Chemical-Society (ACS) CY AUG 19-23, 2012 CL Philadelphia, PA SP Amer Chem Soc, Div Hist Chem, Amer Chem Soc C1 [Jenkins, Amanda L.] Analyt Sci Konsulting Inc, Hebron, MD 21830 USA. [Balboa, Alex; Karwacki, Christopher J.] US Army ECBC, CBR Filtrat Team, Edgewood, MD 21010 USA. [Hurley, Margaret M.] Army Res Lab, WMRD, Aberdeen Proving Ground, MD 21005 USA. EM amanda21801@yahoo.com NR 0 TC 0 Z9 0 U1 0 U2 7 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 19 PY 2012 VL 244 MA 666-COLL PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA 220XX UT WOS:000324621802834 ER PT J AU Killops, KL Rodriguez, C Lynd, NA Hawker, CJ AF Killops, Kato L. Rodriguez, Christina Lynd, Nathaniel A. Hawker, Craig J. TI Hierarchically porous polymer nanoparticle assemblies with modular functionality SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 244th National Fall Meeting of the American-Chemical-Society (ACS) CY AUG 19-23, 2012 CL Philadelphia, PA SP Amer Chem Soc, Div Hist Chem, Amer Chem Soc C1 [Killops, Kato L.] USA, Edgewood Chem Biol Ctr, RDECOM, Aberdeen Proving Ground, MD 21010 USA. [Rodriguez, Christina; Lynd, Nathaniel A.; Hawker, Craig J.] Univ Calif Santa Barbara, Mat Res Lab, Santa Barbara, CA 93106 USA. EM kathryn.l.killops.civ@mail.mil NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 19 PY 2012 VL 244 MA 250-PMSE PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA 220XX UT WOS:000324621808014 ER PT J AU King, AS Peltier, E Michalsen, MM AF King, Aaron S. Peltier, Edward Michalsen, Mandy M. TI Sorption and pH effects on the removal of trace metals from a contaminated alkaline groundwater SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 244th National Fall Meeting of the American-Chemical-Society (ACS) CY AUG 19-23, 2012 CL Philadelphia, PA SP Amer Chem Soc, Div Hist Chem, Amer Chem Soc C1 [King, Aaron S.; Peltier, Edward] Univ Kansas, Dept Civil Environm & Architectural Engn, Lawrence, KS 66045 USA. [Michalsen, Mandy M.] US Army Corps Engineers, Seattle, WA 98124 USA. EM epeltier@ku.edu NR 0 TC 0 Z9 0 U1 0 U2 2 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 19 PY 2012 VL 244 MA 40-GEOC PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA 220XX UT WOS:000324621804599 ER PT J AU Lee, IC Gamson, AS AF Lee, Ivan C. Gamson, Adam S. TI Identification of seed oils SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 244th National Fall Meeting of the American-Chemical-Society (ACS) CY AUG 19-23, 2012 CL Philadelphia, PA SP Amer Chem Soc, Div Hist Chem, Amer Chem Soc C1 [Lee, Ivan C.; Gamson, Adam S.] US Army Res Lab, Sensors & Electron Device Directorate, Adelphi, MD 20783 USA. EM ivan.c.lee2.civ@mail.mil NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 19 PY 2012 VL 244 MA 199-AGFD PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA 220XX UT WOS:000324621800243 ER PT J AU Manocchi, AK Baker, DR Sumner, JJ Pendley, SS Hurley, MM Xu, K Bruce, BD Lundgren, CA AF Manocchi, Amy K. Baker, David R. Sumner, James J. Pendley, Scott S. Hurley, Margaret M. Xu, Kang Bruce, Barry D. Lundgren, Cynthia A. TI Surface-assembled Photosystem I as a biomolecular reactor toward solar energy conversion SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 244th National Fall Meeting of the American-Chemical-Society (ACS) CY AUG 19-23, 2012 CL Philadelphia, PA SP Amer Chem Soc, Div Hist Chem, Amer Chem Soc C1 [Manocchi, Amy K.; Baker, David R.; Sumner, James J.; Lundgren, Cynthia A.] US Army Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA. [Pendley, Scott S.; Hurley, Margaret M.; Xu, Kang] US Army Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. [Bruce, Barry D.] Univ Tennessee, Dept Biochem Cellular & Mol Biol, Knoxville, TN 37996 USA. [Bruce, Barry D.] Univ Tennessee, Dept Chem & Biomol Engn, Knoxville, TN 37996 USA. EM james.j.sumner4.civ@mail.mil NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 19 PY 2012 VL 244 MA 597-COLL PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA 220XX UT WOS:000324621802771 ER PT J AU Morrissey, KM Schenning, AM Cheicante, RL Sumpter, KB AF Morrissey, Kevin M. Schenning, Amanda M. Cheicante, Richard L. Sumpter, Kenneth B. TI Sorption of the chemical warfare agent VX to clay minerals SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 244th National Fall Meeting of the American-Chemical-Society (ACS) CY AUG 19-23, 2012 CL Philadelphia, PA SP Amer Chem Soc, Div Hist Chem, Amer Chem Soc C1 [Morrissey, Kevin M.; Schenning, Amanda M.; Cheicante, Richard L.] Sci Applicat Int Corp, Abingdon, MD 21009 USA. [Sumpter, Kenneth B.] US Army, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. EM kevin.m.morrissey.ctr@mail.mil NR 0 TC 0 Z9 0 U1 1 U2 4 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 19 PY 2012 VL 244 MA 227-ENVR PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA 220XX UT WOS:000324621804444 ER PT J AU Norton, JR Hu, Y Li, L Eberhart, M Shaw, AP AF Norton, Jack R. Hu, Yue Li, Ling Eberhart, Michael Shaw, Anthony P. TI Hydride transfer from M-H: One step vs. two SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 244th National Fall Meeting of the American-Chemical-Society (ACS) CY AUG 19-23, 2012 CL Philadelphia, PA SP Amer Chem Soc, Div Hist Chem, Amer Chem Soc C1 [Norton, Jack R.; Hu, Yue; Eberhart, Michael] Columbia Univ, Chem, New York, NY 10027 USA. [Li, Ling] CUNY, New York, NY 10031 USA. [Shaw, Anthony P.] US Army RDECOM ARDEC, Pyrotech Technol & Prototyping Div, Picatinny Arsenal, NJ 07806 USA. EM jrn11@columbia.edu NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 19 PY 2012 VL 244 MA 67-CATL PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA 220XX UT WOS:000324621801321 ER PT J AU Rawlett, AM AF Rawlett, Adam M. TI Revolutionary materials development leading to transformational capabilities SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 244th National Fall Meeting of the American-Chemical-Society (ACS) CY AUG 19-23, 2012 CL Philadelphia, PA SP Amer Chem Soc, Div Hist Chem, Amer Chem Soc C1 [Rawlett, Adam M.] Army Res Lab, Aberdeen, MD USA. EM adam.m.rawlett.civ@mail.mil NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 19 PY 2012 VL 244 MA 106-POLY PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA 220XX UT WOS:000324621808286 ER PT J AU Rinderspacher, BC AF Rinderspacher, Berend Christopher TI General systematic property optimization in chemical space SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 244th National Fall Meeting of the American-Chemical-Society (ACS) CY AUG 19-23, 2012 CL Philadelphia, PA SP Amer Chem Soc, Div Hist Chem, Amer Chem Soc C1 [Rinderspacher, Berend Christopher] Army Res Labobratory, Aberdeen Proving Ground, MD 21005 USA. EM berend.rinderspacher@us.army.mil NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 19 PY 2012 VL 244 MA 45-COMP PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA 220XX UT WOS:000324621802888 ER PT J AU Sadler, JM Toulan, FR Zaiee, S La Scala, JJ AF Sadler, Joshua M. Toulan, Faye R. Zaiee, Saeed La Scala, John J. TI Development and characterization of carbohydrate derived furanic resins as phenolic analogs SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 244th National Fall Meeting of the American-Chemical-Society (ACS) CY AUG 19-23, 2012 CL Philadelphia, PA SP Amer Chem Soc, Div Hist Chem, Amer Chem Soc C1 [Sadler, Joshua M.; Toulan, Faye R.; Zaiee, Saeed; La Scala, John J.] Army Res Lab, RDRL WMM C, Aberdeen Proving Ground, MD 21005 USA. EM joshua.sadler1.ctr@mail.mil NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 19 PY 2012 VL 244 MA 76-CELL PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA 220XX UT WOS:000324621801447 ER PT J AU Satapathi, S Pal, AK Bheemaraju, A Li, L Bello, D Venkataraman, D Kumar, J AF Satapathi, Soumitra Pal, Anoop K. Bheemaraju, Amarnath Li, Lian Bello, Dhimiter Venkataraman, Dhandapani Kumar, Jayant TI Oligothiophene nanoparticles for high contrast imaging of cancerous cells SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 244th National Fall Meeting of the American-Chemical-Society (ACS) CY AUG 19-23, 2012 CL Philadelphia, PA SP Amer Chem Soc, Div Hist Chem, Amer Chem Soc C1 [Satapathi, Soumitra; Kumar, Jayant] Univ Maasachusetts Lowell, Ctr Adv Mat, Lowell, MA 01854 USA. [Pal, Anoop K.; Bello, Dhimiter] Univ Maasachusetts Lowell, Dept Work Environm, Lowell, MA 01854 USA. [Bheemaraju, Amarnath; Venkataraman, Dhandapani] Univ Massachusetts, Dept Chem, Amherst, MA 01003 USA. [Li, Lian] US Army Natick Soldier Res, Ctr Dev & Engn, Natick, MA 01760 USA. EM soumitra_satapathi@student.uml.edu NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 19 PY 2012 VL 244 MA 116-PMSE PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA 220XX UT WOS:000324621807780 ER PT J AU Schumacher, PD AF Schumacher, Paul D. TI Radiochemistry within the Department of Defense SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 244th National Fall Meeting of the American-Chemical-Society (ACS) CY AUG 19-23, 2012 CL Philadelphia, PA SP Amer Chem Soc, Div Hist Chem, Amer Chem Soc C1 [Schumacher, Paul D.] US Mil Acad, Dept Chem & Life Sci, West Point, NY 10996 USA. EM paul.schumacher@usma.edu NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 19 PY 2012 VL 244 MA 44-NUCL PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA 220XX UT WOS:000324621806190 ER PT J AU Sirk, TW Knox, C Lenhart, JL Andzelm, JW Khare, KS Karmin, M Khare, R AF Sirk, Timothy W. Knox, Craig Lenhart, Joseph L. Andzelm, Jan W. Khare, Ketan S. Karmin, Mir Khare, Rajesh TI Modeling polymer networks SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 244th National Fall Meeting of the American-Chemical-Society (ACS) CY AUG 19-23, 2012 CL Philadelphia, PA SP Amer Chem Soc, Div Hist Chem, Amer Chem Soc C1 [Sirk, Timothy W.; Knox, Craig; Lenhart, Joseph L.; Andzelm, Jan W.] Army Res Lab, Macromol Sci & Technol Branch, Aberdeen Proving Ground, MD 21005 USA. [Khare, Ketan S.; Karmin, Mir; Khare, Rajesh] Texas Tech Univ, Dept Chem Engn, Lubbock, TX 79409 USA. EM tim.sirk@us.army.mil RI Khare, Rajesh/J-2079-2014 OI Khare, Rajesh/0000-0002-8859-766X NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 19 PY 2012 VL 244 MA 302-POLY PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA 220XX UT WOS:000324621808461 ER PT J AU Sliozberg, YR Chantawansri, TL Sirk, TW Mrozek, RA Lenhart, JL Andzelm, JW AF Sliozberg, Yelena R. Chantawansri, Tanya L. Sirk, Timothy W. Mrozek, Randy A. Lenhart, Joseph L. Andzelm, Jan W. TI Modeling polymer gels for defense applications SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 244th National Fall Meeting of the American-Chemical-Society (ACS) CY AUG 19-23, 2012 CL Philadelphia, PA SP Amer Chem Soc, Div Hist Chem, Amer Chem Soc C1 [Sliozberg, Yelena R.; Chantawansri, Tanya L.; Sirk, Timothy W.; Mrozek, Randy A.; Lenhart, Joseph L.; Andzelm, Jan W.] Army Res Lab, Mat & Mfg Sci Div, Aberdeen, MD 21005 USA. EM jan.w.andzelm.civ@mail.mil RI Chantawansri, Tanya/N-3601-2013 NR 0 TC 0 Z9 0 U1 0 U2 3 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 19 PY 2012 VL 244 MA 297-POLY PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA 220XX UT WOS:000324621808456 ER PT J AU Stanzione, JF Sadler, JM La Scala, JJ Wool, RP AF Stanzione, Joseph F., III Sadler, Joshua M. La Scala, John J. Wool, Richard P. TI Methacrylated lignin model compounds as monomers for use in high-performance poylmers SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 244th National Fall Meeting of the American-Chemical-Society (ACS) CY AUG 19-23, 2012 CL Philadelphia, PA SP Amer Chem Soc, Div Hist Chem, Amer Chem Soc C1 [Stanzione, Joseph F., III; Wool, Richard P.] Univ Delaware, Dept Chem & Biomol Engn, Newark, DE 19716 USA. [Sadler, Joshua M.; La Scala, John J.] Army Res Lab, Aberdeen Proving Ground, MD 21005 USA. EM jfstanz@udel.edu NR 0 TC 0 Z9 0 U1 0 U2 2 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 19 PY 2012 VL 244 MA 45-IEC PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA 220XX UT WOS:000324621804677 ER PT J AU Stanzione, JF Sadler, JM La Scala, JJ Wool, RP AF Stanzione, Joseph F., III Sadler, Joshua M. La Scala, John J. Wool, Richard P. TI Methacrylated lignin model compounds as monomers for use in high-performance poylmers SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 244th National Fall Meeting of the American-Chemical-Society (ACS) CY AUG 19-23, 2012 CL Philadelphia, PA SP Amer Chem Soc, Div Hist Chem, Amer Chem Soc C1 [Stanzione, Joseph F., III; Wool, Richard P.] Univ Delaware, Dept Chem & Biomol Engn, Newark, DE 19716 USA. [Sadler, Joshua M.; La Scala, John J.] Army Res Lab, Aberdeen Proving Ground, MD 21005 USA. EM jfstanz@udel.edu NR 0 TC 0 Z9 0 U1 0 U2 2 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 19 PY 2012 VL 244 MA 45-IEC PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA 220XX UT WOS:000324621804676 ER PT J AU Steffen, MR Chapman, MA AF Steffen, Melissa Reinard Chapman, Michael A. TI Thermal decomposition of fire extinguishing agents in military systems SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 244th National Fall Meeting of the American-Chemical-Society (ACS) CY AUG 19-23, 2012 CL Philadelphia, PA SP Amer Chem Soc, Div Hist Chem, Amer Chem Soc C1 [Steffen, Melissa Reinard; Chapman, Michael A.] US Army, Aberdeen Test Ctr, Army Test & Evaluat Command, Aberdeen Proving Ground, MD 21005 USA. EM melissa.r.steffen.civ@mail.mil NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 19 PY 2012 VL 244 MA 126-ANYL PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA 220XX UT WOS:000324621800891 ER PT J AU Tran, DT Dong, H Chu, D AF Tran, Dat T. Dong, Hong Chu, Deryn TI Adsorptive desulfurization of JP-8 fuel using Ag+ - silica monolith based adsorbents at ambient conditions SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 244th National Fall Meeting of the American-Chemical-Society (ACS) CY AUG 19-23, 2012 CL Philadelphia, PA SP Amer Chem Soc, Div Hist Chem, Amer Chem Soc C1 [Tran, Dat T.; Chu, Deryn] US Army Res Lab, RDRL SED C, Adelphi, MD 20783 USA. [Dong, Hong] US Army Res Lab, Macromol Sci & Technol Branch, RDRL WMM G, Aberdeen Proving Ground, MD 21005 USA. EM dat.t.tran4.civ@mail.mil NR 0 TC 0 Z9 0 U1 1 U2 3 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 19 PY 2012 VL 244 MA 104-ENFL PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA 220XX UT WOS:000324621803588 ER PT J AU Uzarski, JR Mello, CM AF Uzarski, Joshua R. Mello, Charlene M. TI Immobilized antimicrobial peptides: From interfacial structure to emerging applications SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 244th National Fall Meeting of the American-Chemical-Society (ACS) CY AUG 19-23, 2012 CL Philadelphia, PA SP Amer Chem Soc, Div Hist Chem, Amer Chem Soc C1 [Uzarski, Joshua R.; Mello, Charlene M.] USA, Natick Soldier Res Dev & Engn Ctr, Natick, MA 01760 USA. [Uzarski, Joshua R.; Mello, Charlene M.] Univ Massachusetts Dartmouth, N Dartmouth, MA 02747 USA. EM juzarski@umassd.edu NR 0 TC 0 Z9 0 U1 1 U2 2 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 19 PY 2012 VL 244 MA 473-COLL PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA 220XX UT WOS:000324621802654 ER PT J AU VanLandingham, MR AF VanLandingham, Mark R. TI Nanomechanics of polymers using AFM-based techniques SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 244th National Fall Meeting of the American-Chemical-Society (ACS) CY AUG 19-23, 2012 CL Philadelphia, PA SP Amer Chem Soc, Div Hist Chem, Amer Chem Soc C1 [VanLandingham, Mark R.] US Army Res Lab, Mat & Mfg Sci Div, Aberdeen Proving Ground, MD 21005 USA. EM mark.r.vanlandingham2.civ@mail.mil NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 19 PY 2012 VL 244 MA 82-POLY PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA 220XX UT WOS:000324621808262 ER PT J AU Winski, D Kreutz, K Osterberg, E Campbell, S Wake, C AF Winski, Dominic Kreutz, Karl Osterberg, Erich Campbell, Seth Wake, Cameron TI High-frequency observations of melt effects on snowpack stratigraphy, Kahiltna Glacier, Central Alaska Range SO HYDROLOGICAL PROCESSES LA English DT Article; Proceedings Paper CT Eastern Snow Conference (ESC) CY 2011 CL Montreal, CANADA DE melt layers; densification; glaciochemistry; Alaska; snow ID GREENLAND ICE-SHEET; MASS-BALANCE; ION CONCENTRATIONS; ISOTOPIC SIGNALS; ENERGY-BALANCE; SEA-LEVEL; WATER; CORE; CAP; TEMPERATURE AB With an increased volume of melt on many of the world's glaciers, study of how meltwater affects the properties of glacial snowpack becomes essential to our understanding of how glaciers will respond to climate change. We address this problem by studying how snow properties changed on sub-daily timescales on the Kahiltna Glacier, Alaska, between May 26 and June 10, 2010. During this period, we dug 1.8-m-deep snow pits twice daily to record the stratigraphy of melt layers, snow hardness, grain size, and density and sampled for hydrogen isotopic composition (delta D) on four occasions. From these data, we show that 65% of the melted surface snow infiltrates and refreezes in the snowpack. This leads to a densification of the snow, a 729% increase in volume of melt layers, and a homogenization of isotopic and physical snow properties. From visual and stratigraphic observations, we show that meltwater flow within the snowpack is conducted primarily along lenses and pipes, where melt layers later form, but that more homogeneous capillary-based flow is also important. Finally, we show using isotope ratios that post-depositional alteration is exacerbated with increased melt extent, using the delta D profile below a volcanic ash layer as a case study. In the future, similar studies would benefit from this high-frequency monitoring approach to assessing snowpack evolution, as it allows for a greater understanding of short duration processes. New directions for study would include longer-term monitoring efforts over a wider spatial snow pit network. Copyright (c) 2012 John Wiley & Sons, Ltd. C1 [Winski, Dominic; Kreutz, Karl] Univ Maine, Climate Change Inst, Orono, ME 04469 USA. [Osterberg, Erich] Dartmouth Coll, Dept Earth Sci, Hanover, NH 03755 USA. [Campbell, Seth] Univ Maine, Dept Earth Sci, Orono, ME USA. [Campbell, Seth] USA, Corps Engineers, Cold Reg Res & Engn Lab, Hanover, NH USA. [Wake, Cameron] Univ New Hampshire, Dept Earth Sci, Durham, NH 03824 USA. RP Winski, D (reprint author), Univ Maine, Climate Change Inst, 5790 Bryand Hall, Orono, ME 04469 USA. EM dominic.winski@gmail.com RI Wake, Cameron/G-8114-2014; OI Wake, Cameron/0000-0002-5961-5902 FU National Science Foundation [ARC-0713974]; Dan and Betty Churchill Exploration Fund; Kingsley Brown Scholarship; Climate Change Institute FX I would like to acknowledge the following people and organizations for their support: Dr. Peter Koons and Dr. Roger Hooke, for their input on this manuscript; Bob Hawley, Sarah Das, and Gifford Wong for their advice on energy balance modelling, snow metamorphism, and glaciochemistry; John Thompson, Kevin Volkening, Loren Rausch, and Austin Johnson for field assistance; the staff of Denali National Park, particularly at Kbase, for general support for our research effort; Douglas Introne, Mike Handley, Sharon Sneed, Jay Holweger, and Bess Koffman for help with chemical analysis; and Talkeetna Air Taxi for transportation and assistance. Funding for this project was provided by the National Science Foundation (ARC-0713974), the Dan and Betty Churchill Exploration Fund, the Kingsley Brown Scholarship, and a Climate Change Institute research assistantship. NR 47 TC 2 Z9 3 U1 2 U2 28 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0885-6087 EI 1099-1085 J9 HYDROL PROCESS JI Hydrol. Process. PD AUG 15 PY 2012 VL 26 IS 17 SI SI BP 2573 EP 2582 DI 10.1002/hyp.9348 PG 10 WC Water Resources SC Water Resources GA 983ME UT WOS:000307122600008 ER PT J AU Daly, SF Vuyovich, CM Deeb, EJ Newman, SD Baldwin, TB Gagnon, JJ AF Daly, Steven F. Vuyovich, Carrie M. Deeb, Elias J. Newman, Stephen D. Baldwin, Timothy B. Gagnon, John J. TI Assessment of the snow conditions in the major watersheds of Afghanistan using multispectral and passive microwave remote sensing SO HYDROLOGICAL PROCESSES LA English DT Article; Proceedings Paper CT Eastern Snow Conference (ESC) CY 2011 CL Montreal, CANADA DE Snow covered area; Snow water equivalent; Remote sensing; Passive microwave; Afghanistan; Hydrology ID SATELLITE DATA; IN-SITU; AMSR-E; MODIS; GENERATION; RADIOMETER; SYSTEM AB Since the winter season of 2004-2005, annual snow assessments have been conducted for the major watersheds of Afghanistan using multispectral (AVHRR and MODIS) and passive microwave (SSM/I and AMSR-E) remote sensing technologies. Because of limited ground-based observations of precipitation and snow pack conditions, remote sensing provides a unique opportunity to assess these conditions at different scales offering an appraisal of current conditions from a historical context. This paper describes the methodology that has been developed over the past seven winter seasons, wherein bi-weekly snow products and assessments are produced including the following: current snow-covered area (SCA) at regional and watershed scales; estimation of SCA by elevation band; current snowpack volume [snow water equivalent (SWE)] for each watershed with a historical perspective (1987present); snow condition outlook by watershed; general summary of snow conditions based on remote sensing products and limited ground-based observations; and if warranted, a snow melt flooding advisory. Further analysis of these snow products and assessments are presented. Moreover, comparisons between both available passive microwave estimates of SWE (SSM/I and AMSR-E) for all watersheds differ in magnitude yet exhibit similar historical trends. The SSM/I versus AMSR-E historical differences in SWE for each of the major Afghanistan watersheds are quantified and show a strong relationship (R2 =96%) to the mean elevation of the watershed. Copyright (c) 2012 John Wiley & Sons, Ltd. C1 [Daly, Steven F.; Vuyovich, Carrie M.; Deeb, Elias J.; Newman, Stephen D.; Baldwin, Timothy B.; Gagnon, John J.] USA, Corps Engineers, Cold Reg Res & Engn Lab, Hanover, NH USA. RP Daly, SF (reprint author), USA, Corps Engineers, Cold Reg Res & Engn Lab, Hanover, NH USA. EM Steven.F.Daly@usace.army.mil NR 50 TC 3 Z9 3 U1 0 U2 16 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0885-6087 EI 1099-1085 J9 HYDROL PROCESS JI Hydrol. Process. PD AUG 15 PY 2012 VL 26 IS 17 SI SI BP 2631 EP 2642 DI 10.1002/hyp.9367 PG 12 WC Water Resources SC Water Resources GA 983ME UT WOS:000307122600014 ER PT J AU Bookstaver, DA Burkhalter, NA Hatzigeorgiou, C AF Bookstaver, David A. Burkhalter, Nancy A. Hatzigeorgiou, Christos TI Effect of Coenzyme Q10 Supplementation on Stalin-Induced Myalgias SO AMERICAN JOURNAL OF CARDIOLOGY LA English DT Article ID COA REDUCTASE INHIBITORS; STATIN-ASSOCIATED MYOPATHY; SERUM UBIQUINONE; DOUBLE-BLIND; Q(10) LEVEL; BLOOD; RISK; ATORVASTATIN; DECREASES; SYMPTOMS AB Coenzyme Q10 (CoQ10) deficiency has been proposed to be causal in 3-hydroxy-3-methyl-glutaryl coenzyme A reductase inhibitor (statin)-induced myopathies. However, the clinical benefit of supplementation is unproved. The purpose of the present study was to assess the effect of CoQ10 supplementation on myalgias presumed to be caused by statins. Patients currently receiving a statin who developed new-onset myalgias in >= 2 extremities within 60 days of initiation or a dosage increase were eligible. Patients continued statin therapy and were randomized using a matched design to either CoQ10 60 mg twice daily or matching placebo. Double-blind treatment continued for 3 months, and patients completed a 10-cm visual analog scale (VAS) and the Short-Form McGill Pain Questionnaire. at baseline and at each monthly visit. The primary end point was the comparison of the VAS score at 1 month. A total of 76 patients were enrolled (40 in the CoQ10 arm and 36 in the placebo arm). The mean VAS score was 6 cm at baseline in both groups. At 1 month, no difference was seen in the mean VAS score between the 2 groups (3.9 cm in the CoQ10 group and 4 cm in the placebo group; p = 0.97). However, 5 patients in the CoQ10 group and 3 in the placebo group discontinued therapy during the first month because of myalgias. The baseline median score on the Sensory Pain Rating Index subscale was 10 in the CoQ10 group and 11.5 in the placebo group. At 1 month, these scores had decreased to 6.5 and 7.5, respectively, with no statistically significant difference (p = 0.34). In conclusion, CoQ10 did not produce a greater response than placebo in the treatment of presumed statin-induced myalgias. Published by Elsevier Inc. (Am J Cardiol 2012;110:526-529) C1 [Bookstaver, David A.; Burkhalter, Nancy A.] Eisenhower Army Med Ctr, Dept Pharm, Ft Gordon, GA USA. [Hatzigeorgiou, Christos] Eisenhower Army Med Ctr, Dept Med, Ft Gordon, GA USA. RP Bookstaver, DA (reprint author), Eisenhower Army Med Ctr, Dept Pharm, Ft Gordon, GA USA. EM david.bookstaver@amedd.army.mil NR 23 TC 35 Z9 35 U1 2 U2 8 PU EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC PI BRIDGEWATER PA 685 ROUTE 202-206 STE 3, BRIDGEWATER, NJ 08807 USA SN 0002-9149 J9 AM J CARDIOL JI Am. J. Cardiol. PD AUG 15 PY 2012 VL 110 IS 4 BP 526 EP 529 DI 10.1016/j.amjcard.2012.04.026 PG 4 WC Cardiac & Cardiovascular Systems SC Cardiovascular System & Cardiology GA 993LK UT WOS:000307861000010 PM 22608359 ER PT J AU Gurton, KP Felton, M Tober, R AF Gurton, Kristan P. Felton, Melvin Tober, Richard TI Selective real-time detection of gaseous nerve agent simulants using multiwavelength photoacoustics SO OPTICS LETTERS LA English DT Article ID FLOW-THROUGH PHOTOACOUSTICS; GAS-DETECTION; SPECTROSCOPY; LASER; SENSOR AB An optical detection method is presented that is designed to detect and identify the presence of macromolecular gas species (e. g., organophosphate-based nerve agent simulants) at trace level concentrations. The technique is based on a modified version of conventional laser photoacoustic (PA) spectroscopy, in which optical absorption is typically measured using a single laser source. We demonstrate the ability to simultaneously measure multiple absorption-related parameters that serve as a concentration-independent identifier. Three continuous wave mid-infrared laser sources, operating at 8.68, 9.29, and 10.35 mu m, are combined and propagated axially through a specially designed flow through PA cell. Each laser is modulated at a different frequency and the resultant acoustic signal(s) are detected and deconvolved using a PC-based 24 bit dynamic signal acquisition device. Species detection and identification is achieved by tabulating independent ratios of the acoustic response for each laser source. Quantitative absorption measured is verified using a Fourier transform infrared spectrometer. Results show good detection and species separation/identification at moderately low ppm concentrations. (C) 2012 Optical Society of America C1 [Gurton, Kristan P.; Felton, Melvin; Tober, Richard] USA, Res Lab, Adelphi, MD 20783 USA. RP Gurton, KP (reprint author), USA, Res Lab, Adelphi, MD 20783 USA. EM kristan.p.gurton.civ@mail.mil NR 9 TC 4 Z9 4 U1 1 U2 21 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 0146-9592 J9 OPT LETT JI Opt. Lett. PD AUG 15 PY 2012 VL 37 IS 16 BP 3474 EP 3476 PG 3 WC Optics SC Optics GA 994TY UT WOS:000307956700061 PM 23381295 ER PT J AU Motamarri, P Iyer, M Knap, J Gavini, V AF Motamarri, Phani Iyer, Mrinal Knap, Jaroslaw Gavini, Vikram TI Higher-order adaptive finite-element methods for orbital-free density functional theory SO JOURNAL OF COMPUTATIONAL PHYSICS LA English DT Article DE Density functional theory; Real space; Finite elements; Spectral elements; Convergence; Computational efficiency ID ELECTRONIC-STRUCTURE CALCULATIONS; NONSYMMETRIC LINEAR-SYSTEMS; KINETIC-ENERGY FUNCTIONALS; MINIMAL RESIDUAL ALGORITHM; BASIS-SET; MESH; GAS; APPROXIMATIONS; DYNAMICS; EQUATION AB In the present work, we study various numerical aspects of higher-order finite-element discretizations of the non-linear saddle-point formulation of orbital-free density-functional theory. We first investigate the robustness of viable solution schemes by analyzing the solvability conditions of the discrete problem. We find that a staggered solution procedure where the potential fields are computed consistently for every trial electron-density is a robust solution procedure for higher-order finite-element discretizations. We next study the convergence properties of higher-order finite-element discretizations of orbital-free density functional theory by considering benchmark problems that include calculations involving both pseudopotential as well as Coulomb singular potential fields. Our numerical studies suggest close to optimal rates of convergence on all benchmark problems for various orders of finite-element approximations considered in the present study. We finally investigate the computational efficiency afforded by various higher-order finite-element discretizations, which constitutes the main aspect of the present work, by measuring the CPU time for the solution of discrete equations on benchmark problems that include large Aluminum clusters. In these studies, we use mesh coarse-graining rates that are derived from error estimates and an a priori knowledge of the asymptotic solution of the far-field electronic fields. Our studies reveal a significant 100-1000 fold computational savings afforded by the use of higher-order finite-element discretization, alongside providing the desired chemical accuracy. We consider this study as a step towards developing a robust and computationally efficient discretization of electronic structure calculations using the finite-element basis. (C) 2012 Elsevier Inc. All rights reserved. C1 [Motamarri, Phani; Iyer, Mrinal; Gavini, Vikram] Univ Michigan, Dept Mech Engn, Ann Arbor, MI 48109 USA. [Knap, Jaroslaw] USA, Res Labs, Aberdeen, MD 21001 USA. RP Gavini, V (reprint author), Univ Michigan, Dept Mech Engn, Ann Arbor, MI 48109 USA. EM vikramg@umich.edu RI Gavini, Vikram/J-9725-2012 OI Gavini, Vikram/0000-0002-9451-2300 FU Air Force Office of Scientific Research [FA9550-09-1-0240]; Army Research Office [W911NF-09-0292]; National Science Foundation [CMMI 0927478] FX We thank Kenneth Leiter (U.S. Army Research Labs) for assistance in improving the software architecture of the code that is used to conduct our simulations. We gratefully acknowledge the support of Air Force Office of Scientific Research under Grant No. FA9550-09-1-0240 and Army Research Office under Grant No. W911NF-09-0292. VG also gratefully acknowledges the support of National Science Foundation under Grant No. CMMI 0927478. NR 54 TC 12 Z9 12 U1 0 U2 9 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0021-9991 EI 1090-2716 J9 J COMPUT PHYS JI J. Comput. Phys. PD AUG 15 PY 2012 VL 231 IS 20 BP 6596 EP 6621 DI 10.1016/j.jcp.2012.04.036 PG 26 WC Computer Science, Interdisciplinary Applications; Physics, Mathematical SC Computer Science; Physics GA 985VU UT WOS:000307299400002 ER PT J AU Hoge, CW Castro, CA AF Hoge, Charles W. Castro, Carl A. TI Preventing Suicides in US Service Members and Veterans Concerns After a Decade of War SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION LA English DT Editorial Material ID DEPLOYMENT; MILITARY C1 [Hoge, Charles W.] Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. [Castro, Carl A.] USA, Med Res & Mat Command, Ft Detrick, MD USA. RP Hoge, CW (reprint author), Walter Reed Army Inst Res, 501 Robert Grant Ave, Silver Spring, MD 20910 USA. EM charles.hoge@us.army.mil NR 10 TC 42 Z9 42 U1 2 U2 6 PU AMER MEDICAL ASSOC PI CHICAGO PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA SN 0098-7484 EI 1538-3598 J9 JAMA-J AM MED ASSOC JI JAMA-J. Am. Med. Assoc. PD AUG 15 PY 2012 VL 308 IS 7 BP 671 EP 672 DI 10.1001/jama.2012.9955 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA 988NC UT WOS:000307496700018 PM 22893160 ER PT J AU Yin, JM Vahey, MT Dai, AL Lewis, MG Arango, T Yalley-Ogunro, J Greenhouse, J Mendoza, K Khan, A Sardesai, NY Weiss, W Komisar, J Boyer, JD AF Yin, Jiangmei Vahey, Maryanne T. Dai, Anlan Lewis, Mark G. Arango, Tatiana Yalley-Ogunro, Jake Greenhouse, Jack Mendoza, Karla Khan, Amir Sardesai, Niranjan Y. Weiss, Walter Komisar, Jack Boyer, Jean D. TI Plasmodium inui Infection Reduces the Efficacy of a Simian Immunodeficiency Virus DNA Vaccine in a Rhesus Macaque Model Through Alteration of the Vaccine-Induced Immune Response SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article ID REGULATORY T-CELLS; NECROSIS-FACTOR-ALPHA; ANTIRETROVIRAL THERAPY; FALCIPARUM MALARIA; RURAL MALAWI; HIV; DEPLETION; DISEASE; MEMORY; ADULTS AB Human immunodeficiency virus type 1 and malaria are co-endemic in many areas. We evaluated the effects of Plasmodium inui infection on the performance of a simian immunodeficiency virus (SIV) DNA vaccine. Rhesus macaques were infected with P. inui by transfusion of whole blood from a persistently infected animal. Animals with and animals without P. inui infection were then vaccinated 4 times with an SIV DNA vaccine encoding SIVgag, SIVpol, and SIVenv. Animals were subsequently challenged with thirty 50% rhesus monkey infectious doses of SIVmac251 6 weeks after the last vaccination. P. inui-infected immunized animals showed a significantly higher viral load than animals without P. inui infection (P = .010, by the Wilcoxon rank sum test). The higher viral loads in the P. inui-infected animals were durable and were observed at all sampling time points across the study (P = .00245, by the Wilcoxon rank test). The P. inui-infected animals also had correspondingly lower CD4(+) cell counts. There were fewer vaccine-specific CD4(+) and CD8(+) cells in the P. inui-infected animals, compared with uninfected animals. Of importance, P. inui infection seemed to decrease the number of CD8(+) cells that could proliferate or secrete interferon gamma, although the number of CD8(+) cells capable of secreting tumor necrosis factor a following in vitro stimulation was increased. This study demonstrated that P. inui infection had an influence on the immune response to an SIV DNA vaccine and decreased the vaccine's efficacy. C1 [Yin, Jiangmei; Dai, Anlan; Arango, Tatiana; Boyer, Jean D.] Univ Penn, Sch Med, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA. [Khan, Amir; Sardesai, Niranjan Y.] Inovio Pharmaceut, Blue Bell, PA USA. [Vahey, Maryanne T.] Walter Reed Army Inst Res, Mil HIV Res Program, Silver Spring, MD USA. [Komisar, Jack] Walter Reed Army Inst Res, Mil Malaria Res Program, Silver Spring, MD USA. [Weiss, Walter] Natl Navy Res Ctr, Silver Spring, MD USA. [Lewis, Mark G.; Yalley-Ogunro, Jake; Greenhouse, Jack; Mendoza, Karla] Bioqual, Rockville, MD USA. RP Boyer, JD (reprint author), Univ Penn, Sch Med, Dept Pathol & Lab Med, 505 SCL,422 Curie Blvd, Philadelphia, PA 19104 USA. EM boyerj@mail.med.upenn.edu FU National Institutes of Health [5R01A1071886-04]; Medical Infectious Disease Research Program of the US Army Medical Research and Material Command FX This work was support in part by the National Institutes of Health (grant 5R01A1071886-04) and the Medical Infectious Disease Research Program of the US Army Medical Research and Material Command (to M. T. V.). Inovio provided DNA for the immunization, and primate studies were conducted at Bioqual (by M.G.L.) NR 33 TC 5 Z9 5 U1 0 U2 6 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD AUG 15 PY 2012 VL 206 IS 4 BP 523 EP 533 DI 10.1093/infdis/jis404 PG 11 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 977MQ UT WOS:000306667000010 PM 22693228 ER PT J AU Kremsner, PG Taylor, T Issifou, S Kombila, M Chimalizeni, Y Kawaza, K Akotet, MKB Duscha, M Mordmuller, B Kosters, K Humberg, A Miller, RS Weina, P Duparc, S Mohrle, J Kun, JFJ Planche, T Teja-Isavadharm, P Simpson, JA Kohler, C Krishna, S AF Kremsner, Peter Gottfried Taylor, Terrie Issifou, Saadou Kombila, Maryvonne Chimalizeni, Yamikani Kawaza, Kondwana Akotet, Marielle K. Bouyou Duscha, Mattias Mordmueller, Benjamin Koesters, Katrin Humberg, Alexander Miller, R. Scott Weina, Peter Duparc, Stephan Moehrle, Joerg Kun, Juergen F. J. Planche, Tim Teja-Isavadharm, Paktiya Simpson, Julie Anne Koehler, Carsten Krishna, Sanjeev TI A Simplified Intravenous Artesunate Regimen for Severe Malaria-Reply SO JOURNAL OF INFECTIOUS DISEASES LA English DT Letter ID FALCIPARUM-MALARIA; AFRICAN CHILDREN; PLASMODIUM-FALCIPARUM C1 [Planche, Tim; Krishna, Sanjeev] St Georges Univ London, Ctr Infect, Div Clin Sci, London SW17 0RE, England. [Kremsner, Peter Gottfried; Issifou, Saadou; Duscha, Mattias; Mordmueller, Benjamin; Koesters, Katrin; Humberg, Alexander; Kun, Juergen F. J.; Koehler, Carsten] Univ Tubingen, Inst Tropenmed, Tubingen, Germany. [Kremsner, Peter Gottfried; Issifou, Saadou; Duscha, Mattias; Mordmueller, Benjamin; Planche, Tim; Krishna, Sanjeev] Albert Schweitzer Hosp, Med Res Unit, Lambarene, Gabon. [Taylor, Terrie] Univ Malawi, Coll Med, Blantyre Malaria Project, Blantyre 3, Malawi. [Taylor, Terrie] Michigan State Univ, Coll Osteopath Med, E Lansing, MI 48824 USA. [Kombila, Maryvonne; Akotet, Marielle K. Bouyou] Fac Med & Sci Sante, Dept Parasitol Mycol & Med Trop, Libreville, Gabon. [Chimalizeni, Yamikani] Univ Malawi, Coll Med, Malawi Liverpool Wellcome Trust Clin Res Programm, Blantyre, Malawi. [Kawaza, Kondwana] Queen Elizabeth Cent Hosp, Dept Paediat, Blantyre, Malawi. [Miller, R. Scott; Weina, Peter] Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD USA. [Duparc, Stephan] Int Ctr Contrin, Med Malaria Venture, Geneva, Switzerland. [Teja-Isavadharm, Paktiya] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Simpson, Julie Anne] Univ Melbourne, Sch Populat Hlth, Ctr MEGA Epidemiol, Melbourne, Vic, Australia. RP Krishna, S (reprint author), St Georges Univ London, Ctr Infect, Div Clin Sci, London SW17 0RE, England. EM s.krishna@sgul.ac.uk RI Weina, Peter/A-2120-2011; OI Simpson, Julie/0000-0002-2660-2013; Krishna, Sanjeev/0000-0003-0066-0634 NR 8 TC 2 Z9 2 U1 0 U2 2 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD AUG 15 PY 2012 VL 206 IS 4 BP 621 EP 622 DI 10.1093/infdis/jis391 PG 2 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 977MQ UT WOS:000306667000024 ER PT J AU Villeneuve, DL Garcia-Reyero, N Martinovic-Weigelt, D Li, ZH Watanabe, KH Orlando, EF LaLone, CA Edwards, SW Burgoon, LD Denslow, ND Perkins, EJ Ankley, GT AF Villeneuve, Daniel L. Garcia-Reyero, Natalia Martinovic-Weigelt, Dalma Li, Zhenhong Watanabe, Karen H. Orlando, Edward F. LaLone, Carlie A. Edwards, Stephen W. Burgoon, Lyle D. Denslow, Nancy D. Perkins, Edward J. Ankley, Gerald T. TI A graphical systems model and tissue-specific functional gene sets to aid transcriptomic analysis of chemical impacts on the female teleost reproductive axis SO MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS LA English DT Article DE Systems biology; Toxicogenomics; Gene set enrichment analysis; Fish; Endocrine ID ENRICHMENT ANALYSIS; GENOME DUPLICATION; OOCYTE MATURATION; EXPRESSION; ZEBRAFISH; GROWTH; FISH; RNA AB Oligonucleotide microarrays and other 'omics' approaches are powerful tools for unsupervised analysis of chemical impacts on biological systems. However, the lack of well annotated biological pathways for many aquatic organisms, including fish, and the limited power of microarray-based analyses to detect low level differential expression of individual genes can hinder the ability to infer and understand chemical effects based on transcriptomic data. Here we report on the supervised assembly of a series of tissue-specific functional gene sets intended to aid transcriptomic analysis of chemical impacts on the female teleost reproductive axis. Gene sets were defined based on an updated graphical systems model of the teleost brain-pituitary-gonadal-hepatic axis. Features depicted in the model were organized into gene sets and mapped to specific probes on three zebrafish (Danio rerio) and two fathead minnow (Pimephales promelas) microarray platforms. Coverage of target genes on the microarrays ranged from 48% for the fathead minnow arrays to 88% for the most current zebrafish platform. Additionally, extended fathead minnow gene sets, incorporating first degree neighbors identified from a Spearman correlation network derived from a large compendium of fathead minnow microarray data, were constructed. Overall, only 14% of the 78 genes queried were connected in the network. Among those, over half had less than five neighbors, while two genes, cyclin b1 and zona pellucida glycoprotein 3, had over 100 first degree neighbors, and were neighbors to one another. Gene set enrichment analyses were conducted using microarray data from a zebrafish hypoxia experiment and fathead minnow time-course experiments conducted with three different endocrine-active chemicals. Results of these analyses demonstrate the utility of the approach for supporting biological inference from ecotoxicogenomic data and comparisons across multiple toxicogenomic experiments. The graphical model, gene mapping, and gene sets described are now available to the scientific community as tools to support ecotoxicogenomic research. Published by Elsevier B.V. C1 [Villeneuve, Daniel L.; LaLone, Carlie A.; Ankley, Gerald T.] US EPA, Midcontinent Ecol Div, Duluth, MN 55804 USA. [Garcia-Reyero, Natalia] Mississippi State Univ, Inst Genom Biocomp & Biotechnol, Starkville, MS 39762 USA. [Martinovic-Weigelt, Dalma] Univ St Thomas, Dept Biol, St Paul, MN 55105 USA. [Li, Zhenhong; Watanabe, Karen H.] Oregon Hlth & Sci Univ, Div Sci & Engn, Beaverton, OR 97006 USA. [Orlando, Edward F.] Univ Maryland, Dept Anim & Avian Sci, College Pk, MD 20742 USA. [Edwards, Stephen W.] US EPA, NHEERL, Res Triangle Pk, NC 27711 USA. [Burgoon, Lyle D.] US EPA, NCEA, Res Triangle Pk, NC 27711 USA. [Denslow, Nancy D.] Univ Florida, Dept Physiol Sci, Gainesville, FL 32611 USA. [Denslow, Nancy D.] Ctr Environm & Human Toxicol, Gainesville, FL 32611 USA. [Perkins, Edward J.] USA, Engn Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Villeneuve, DL (reprint author), US EPA, Midcontinent Ecol Div, 6201 Congdon Blvd, Duluth, MN 55804 USA. EM Villeneuve.dan@epa.gov; Natalia@icnanotox.org; dalma@stthomas.edu; zli@thehamner.org; watanabe@ebs.ogi.edu; eorlando@umd.edu; lalone.carlie@epa.gov; Edwards.stephen@epa.gov; burgoon.lyle@epa.gov; ndenslow@ufl.edu; Edward.J.Perkins@usace.army.mil; ankley.gerald@epa.gov RI li, zhenhong/B-1699-2014; OI Martinovic-Weigelt, Dalma/0000-0002-9973-4965; Burgoon, Lyle/0000-0003-4977-5352 FU US EPA; US Army Environmental Quality Research Program [BAA 11-4838]; Medical Research Foundation of Oregon [0634]; US EPA Science to Achieve Results (STAR) program [RD-831848-01-0]; Division of Environmental and Biomolecular Systems at Oregon Health and Science University; University of Maryland FX This manuscript has been subjected to review by the US Environmental Protection Agency (US EPA), National Health and Environmental Effects Research Laboratory and approved for publication. Approval does not signify that the contents reflect the views of the Agency, nor does the mention of trade names or commercial products constitute endorsement or recommendation for use. The authors thank Jon Haselman and Rong-lin Wang for helpful comments on the manuscript. Primary funding for this work was provided by the US EPA and the US Army Environmental Quality Research Program (including BAA 11-4838). Additional contributions to this work were supported by grants from the Medical Research Foundation of Oregon [Grant #0634 to K.H.W.], US EPA Science to Achieve Results (STAR) program [Cooperative Agreement #RD-831848-01-0 to N.D.D., K.H.W., E.F.O.], the Division of Environmental and Biomolecular Systems at Oregon Health and Science University [Z.L.], and University of Maryland [E.F.O.]. NR 37 TC 11 Z9 11 U1 0 U2 28 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1383-5718 J9 MUTAT RES-GEN TOX EN JI Mutat. Res. Genet. Toxicol. Environ. Mutagen. PD AUG 15 PY 2012 VL 746 IS 2 SI SI BP 151 EP 162 DI 10.1016/j.mrgentox.2011.12.016 PG 12 WC Biotechnology & Applied Microbiology; Genetics & Heredity; Toxicology SC Biotechnology & Applied Microbiology; Genetics & Heredity; Toxicology GA 972TW UT WOS:000306304400008 PM 22227403 ER PT J AU Tsai, PC Fox, N Bigley, AN Harvey, SP Barondeau, DP Raushel, FM AF Tsai, Ping-Chuan Fox, Nicholas Bigley, Andrew N. Harvey, Steven P. Barondeau, David P. Raushel, Frank M. TI Enzymes for the Homeland Defense: Optimizing Phosphotriesterase for the Hydrolysis of Organophosphate Nerve Agents SO BIOCHEMISTRY LA English DT Article ID PSEUDOMONAS-DIMINUTA; DIRECTED EVOLUTION; BACTERIAL PHOSPHOTRIESTERASE; STEREOCHEMICAL SPECIFICITY; DEGRADING ENZYME; ACTIVE-SITE; DEGRADATION; MUTAGENESIS; HYDROLASE; SOMAN AB Phosphotriesterase (PTE) from soil bacteria is known for its ability to catalyze the detoxification of organophosphate pesticides and chemical warfare agents. Most of the organophosphate chemical warfare agents are a mixture of two stereoisomers at the phosphorus center, and the S-p-enantiomers are significantly more toxic than the R-p-enantiomers. In previous investigations, PTE variants were created through the manipulation of the substrate binding pockets and these mutants were shown to have greater catalytic activities for the detoxification of the more toxic S-p-enantiomers of nerve agent analogues for GB, GD, GF, VX, and VR than the less toxic R-p-enantiomers. In this investigation, alternate strategies were employed to discover additional PTE variants with significant improvements in catalytic activities relative to that of the wild-type enzyme. Screening and selection techniques were utilized to isolate PTE variants from randomized libraries and site specific modifications. The catalytic activities of these newly identified PTE variants toward the S-p-enantiomers of chromophoric analogues of GB, GD, GF, VX, and VR have been improved up to 15000-fold relative to that of the wild-type enzyme. The X-ray crystal structures of the best PTE variants were determined. Characterization of these mutants with the authentic G-type nerve agents has confirmed the expected improvements in catalytic activity against the most toxic enantiomers of GB, GD, and GF. The values of k(cat)/K-m for the H257Y/L303T (YT) mutant for the hydrolysis of GB, GD, and GF were determined to be 2 x 10(6), 5 x 10(5), and 8 x 10(5) M-1 s(-1), respectively. The YT mutant is the most proficient enzyme reported thus far for the detoxification of G-type nerve agents. These results support a combinatorial strategy of rational design and directed evolution as a powerful tool for the discovery of more efficient enzymes for the detoxification of organophosphate nerve agents. C1 [Tsai, Ping-Chuan; Fox, Nicholas; Bigley, Andrew N.; Barondeau, David P.; Raushel, Frank M.] Texas A&M Univ, Dept Chem, College Stn, TX 77842 USA. [Harvey, Steven P.] USA, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. RP Barondeau, DP (reprint author), Texas A&M Univ, Dept Chem, POB 30012, College Stn, TX 77842 USA. EM barondeau@chem.tamu.eu; raushel@tamu.edu RI Raushel, Frank/B-7125-2015; Barondeau, David/D-6736-2015 OI Raushel, Frank/0000-0002-5918-3089; Barondeau, David/0000-0002-6422-9053 FU NIH [GM 68550] FX This work was supported in part by the NIH (GM 68550). NR 36 TC 41 Z9 43 U1 3 U2 54 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0006-2960 J9 BIOCHEMISTRY-US JI Biochemistry PD AUG 14 PY 2012 VL 51 IS 32 BP 6463 EP 6475 DI 10.1021/bi300811t PG 13 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA 988GY UT WOS:000307478700019 PM 22809162 ER PT J AU Farthing, MW Seyedabbasi, MA Imhoff, PT Miller, CT AF Farthing, M. W. Seyedabbasi, M. A. Imhoff, P. T. Miller, C. T. TI Influence of porous media heterogeneity on nonaqueous phase liquid dissolution fingering and upscaled mass transfer SO WATER RESOURCES RESEARCH LA English DT Article ID DISTRIBUTED IMMISCIBLE LIQUID; SATURATED SUBSURFACE SYSTEMS; SOURCE ZONE ARCHITECTURE; DNAPL SOURCE ZONES; LIGHT TRANSMISSION; NAPL DISSOLUTION; LABORATORY EXPERIMENTS; CONTAMINANT FLUX; TRANSFER RATES; TRACER TESTS AB The utility of existing models for describing upscaled mass transfer from nonaqueous phase liquid (NAPL) were examined when preferential dissolution pathways form in NAPL-contaminated zones that extend over the scale of decimeters. Laboratory experiments were conducted in two well-characterized, heterogeneous packings. Using data from these experiments and simulations, existing methods for upscaling the mass transfer rate coefficient for NAPL dissolution based on dissolution front length growth (LDF), aquifer heterogeneity and spatial moments of NAPL distribution, and the ganglia-to-pool ratio (GTP) were evaluated along with an equilibrium stream tube (EST) model for predicting contaminant flux. When the correlation length of permeability perpendicular to the mean water flow direction was 6.0 cm, greater than the scale of dissolution fingers, only 4.8% of the NAPL resided in pools. Dissolution fingers formed in this experiment, and the LDF, GTP, and EST models resulted in similar predictions of effluent concentrations, with root-mean-square errors (RMSEs) between 0.035 and 0.079 and the LDF-heterogeneous model best. When the correlation scale was smaller (1.0 cm), 66.7% of the NAPL was in pools, and preferential dissolution pathways were dominated by channeling, preferential dissolution caused by spatial variations in aqueous phase permeability, and NAPL saturation. For this experiment the EST and GTP models performed well, with RMSEs of 0.055 and 0.103, respectively. Dissolution fingering was important when the permeability correlation length was sufficiently large that dissolution finger formation was not disrupted and NAPL pools were not dominant. C1 [Imhoff, P. T.] Univ Delaware, Dept Civil & Environm Engn, Newark, DE 19716 USA. [Farthing, M. W.] USA, Coastal & Hydraul Lab, Ctr Res & Dev, Vicksburg, MS USA. [Seyedabbasi, M. A.] GSI Environm Inc, Houston, TX USA. [Miller, C. T.] Univ N Carolina, Dept Environm Sci & Engn, Chapel Hill, NC USA. RP Imhoff, PT (reprint author), Univ Delaware, Dept Civil & Environm Engn, 344A DuPont Hall, Newark, DE 19716 USA. EM imhoff@udel.edu RI Miller, Cass T./I-6613-2012; Imhoff, Paul/B-5085-2013 OI Miller, Cass T./0000-0001-6082-9273; FU National Science Foundation [0440236] FX Nathan Kiracofe provided considerable assistance in preparing the heterogeneous packing, light transmission measurements, and effluent concentration measurements. Doug Baker's efforts in fabricating the experimental apparatus is gratefully acknowledged. This work was supported by the National Science Foundation grant 0440236, and permission was granted by the Chief of Engineers to publish this information. NR 72 TC 10 Z9 10 U1 1 U2 28 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA SN 0043-1397 J9 WATER RESOUR RES JI Water Resour. Res. PD AUG 11 PY 2012 VL 48 AR W08507 DI 10.1029/2011WR011389 PG 20 WC Environmental Sciences; Limnology; Water Resources SC Environmental Sciences & Ecology; Marine & Freshwater Biology; Water Resources GA 988AZ UT WOS:000307461900001 ER PT J AU McNutt, P Lyman, M Swartz, A Tuznik, K Kniffin, D Whitten, K Milhorn, D Hamilton, T AF McNutt, Patrick Lyman, Megan Swartz, Adam Tuznik, Kaylie Kniffin, Denise Whitten, Kim Milhorn, Denise Hamilton, Tracey TI Architectural and Biochemical Expressions of Mustard Gas Keratopathy: Preclinical Indicators and Pathogenic Mechanisms SO PLOS ONE LA English DT Article ID IN-SITU KERATOMILEUSIS; SULFUR MUSTARD; CONFOCAL MICROSCOPY; EPITHELIAL INGROWTH; INJURY; KERATOCYTE; RABBITS; CORNEA; APOPTOSIS; SYSTEM AB A subset of victims of ocular sulfur mustard (SM) exposure develops an irreversible, idiotypic keratitis with associated secondary pathologies, collectively referred to as mustard gas keratopathy (MGK). MGK involves a progressive corneal degeneration resulting in chronic ocular discomfort and impaired vision for which clinical interventions have typically had poor outcomes. Using a rabbit corneal vapor exposure model, we previously demonstrated a clinical progression with acute and chronic sequelae similar to that observed in human casualties. However, a better understanding of the temporal changes that occur during the biphasic SM injury is crucial to mechanistic understanding and therapeutic development. Here we evaluate the histopathologic, biochemical and ultrastructural expressions of pathogenesis of the chronic SM injury over eight weeks. We confirm that MGK onset exhibits a biphasic trajectory involving corneal surface regeneration over the first two weeks, followed by the rapid development and progressive degeneration of corneal structure. Preclinical markers of corneal dysfunction were identified, including destabilization of the basal corneal epithelium, basement membrane zone abnormalities and stromal deformation. Clinical sequelae of MGK appeared abruptly three weeks after exposure, and included profound anterior edema, recurring corneal erosions, basement membrane disorganization, basal cell necrosis and stromal degeneration. Unlike resolved corneas, MGK corneas exhibited frustrated corneal wound repair, with significantly elevated histopathology scores. Increased lacrimation, disruption of the basement membrane and accumulation of pro-inflammatory mediators in the aqueous humor provide several mechanisms for corneal degeneration. These data suggest that the chronic injury is fundamentally distinct from the acute lesion, involving injury mechanisms that operate on different time scales and in different corneal tissues. Corneal edema appears to be the principal pathology of MGK, in part resulting from persistent necrosis of the basal corneal epithelium and deterioration of the basement membrane. The findings also provide a potential explanation as to why administration of anti-inflammatories transiently delays, but does not prevent, the development of MGK sequelae. C1 [McNutt, Patrick; Lyman, Megan; Swartz, Adam; Tuznik, Kaylie; Kniffin, Denise; Whitten, Kim; Hamilton, Tracey] USA, Med Res Inst Chem Def, Aberdeen Proving Ground, MD 21010 USA. [Milhorn, Denise] USA, Med Res & Mat Command, Ft Detrick, MD USA. RP McNutt, P (reprint author), USA, Med Res Inst Chem Def, Aberdeen Proving Ground, MD 21010 USA. EM patrick.mcnutt@us.army.mil OI McNutt, Patrick/0000-0002-5703-4565 FU DTRA - Joint Science and Technology Office, Medical ST Division [2.F0012_08_RC_C, CBM.CUTOC.01.10.RC.003] FX This research was supported by the DTRA - Joint Science and Technology Office, Medical S&T Division (http://www.dtra.mil/Home.aspx), grants 2.F0012_08_RC_C and CBM.CUTOC.01.10.RC.003. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 39 TC 7 Z9 7 U1 0 U2 2 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD AUG 10 PY 2012 VL 7 IS 8 AR e42837 DI 10.1371/journal.pone.0042837 PG 10 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 986XO UT WOS:000307380900074 PM 22900056 ER PT J AU Convertino, M Welle, P Munoz-Carpena, R Kiker, GA Chu-Agor, ML Fischer, RA Linkov, I AF Convertino, Matteo Welle, Paul Munoz-Carpena, Rafael Kiker, Gregory A. Chu-Agor, Ma. L. Fischer, Richard A. Linkov, Igor TI Epistemic uncertainty in predicting shorebird biogeography affected by sea-level rise SO ECOLOGICAL MODELLING LA English DT Article DE Species distribution models; Epistemic uncertainty; Land-cover; Calibration; MAXENT; Snowy Plover ID CLIMATE-CHANGE; SPECIES DISTRIBUTION; POTENTIAL DISTRIBUTIONS; DISTRIBUTION MODELS; SNOWY PLOVERS; HABITAT; ENVELOPE; PERSPECTIVE; SELECTION; SERVICES AB Accurate spatio-temporal predictions of land-cover are fundamentally important for assessing geomorphological and ecological patterns and processes. This study quantifies the epistemic uncertainty in the species distribution modeling, which is generated by spatio-temporal gaps between the biogeographical data, model selection and model complexity. Epistemic uncertainty is generally given by the sum of subjective and objective uncertainty. The subjective uncertainty generated by the modeler-choice in the manipulation of the environmental variables was analyzed. The Snowy Plover in Florida (Charadrius alexandrinus nivosus, SP), a residential shorebird whose geographic range is extended along the Panhandle-Big Bend-Peninsula Gulf coast was considered as case-study. The first fundamental step for studying the species distribution and how it will be affected by climate change is to obtain an accurate description of the shorebird coastal habitat. The land-cover was translated into ecosystem classes using a land-cover model that predicts the evolution of coastal ecosystems affected by sea-level rise scenarios. The best land-cover map decreased the objective uncertainty (intrinsically present in data or models) in representing the spatial structure of the coastal ecosystem, reduced the temporal gaps with the occurrence data, and diminished the subjective uncertainty due to the conversion from land-cover to model-classes. Multimodeling was performed to reduce the uncertainty in the prediction of the species distribution related to model uncertainty. The best representation of the species distribution was performed by MAXENT. The area under the receiver operating characteristic curve (AUC), the omission/commission test, the similarity index of the response curves, and the jackknife test were used simultaneously as indicators of the predictability of each species distribution model. The availability of updated high-resolution biogeoclimatological data was proven to be necessary in order to properly predict the species ranges for conservation purposes. (C) 2012 Elsevier B.V. All rights reserved. C1 [Convertino, Matteo; Welle, Paul; Linkov, Igor] USA Corps Engineers, ERDC, Risk & Decis Sci Team, Concord, MA 01742 USA. [Convertino, Matteo; Munoz-Carpena, Rafael; Kiker, Gregory A.; Chu-Agor, Ma. L.] Univ Florida, IFAS, Dept Agr & Biol Engn, Gainesville, FL 32611 USA. [Welle, Paul] MIT, Dept Civil & Environm Engn, Cambridge, MA 02139 USA. [Welle, Paul; Linkov, Igor] Carnegie Mellon Univ, Dept Engn & Publ Policy, Pittsburgh, PA 15213 USA. [Chu-Agor, Ma. L.] St Louis Univ, Dept Biol, St Louis, MO 63103 USA. [Fischer, Richard A.] USA Corps Engineers, Environm Lab, Vicksburg, MS USA. RP Convertino, M (reprint author), USA Corps Engineers, ERDC, Risk & Decis Sci Team, Concord, MA 01742 USA. EM mconvertino@ufl.edu RI Munoz-Carpena, Rafael/A-7588-2010; OI Munoz-Carpena, Rafael/0000-0003-2838-1514; Chu, Ma Librada/0000-0003-3732-7165 FU SERDP-DOD [SI-1699] FX The authors acknowledge the funds from SERDP-DOD (project SI-1699). Two anonymous reviewers are gratefully acknowledged for the comments about the first version of the manuscript. MC acknowledges Jason Roberts and Ben Best (Duke University) for the support with the GAM and GLM codes, Renato De Giovanni (CRIA) for the assistance with openModeller, and Jason K. Blackburn (Emerging Pathogens Institute & Department of Geography, University of Florida) for the stimulating discussion about GARPbs and MAXENT. MC also is grateful for the service made by Google Earth Pro (Google Earth Pro #621778859). R.A. Pruner (MSc University of Florida) is gratefully acknowledged for the discussions about the biology of the SP and the data collected on the field. K. Baker and M. Barber (MIT) are kindly acknowledged for reviewing the latest version of the manuscript. The research was finalized when Paul Welle performed his research internship at the Risk and Decision Science Team advised by IL and MC. MLC-A was at the University of Florida at the time of this research. Permission was granted by the USACE Chief of Engineers to publish this material. The views and opinions expressed in this paper are those of the individual authors and not those of the US Army, or other sponsor organizations. NR 77 TC 10 Z9 10 U1 1 U2 26 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0304-3800 J9 ECOL MODEL JI Ecol. Model. PD AUG 10 PY 2012 VL 240 BP 1 EP 15 DI 10.1016/j.ecolmodel.2012.04.012 PG 15 WC Ecology SC Environmental Sciences & Ecology GA 978UB UT WOS:000306770200001 ER PT J AU Sinitksi, EH Terry, K Wilken, JM Dingwell, JB AF Sinitksi, Emily H. Terry, Kevin Wilken, Jason M. Dingwell, Jonathan B. TI Effects of perturbation magnitude on dynamic stability when walking in destabilizing environments SO JOURNAL OF BIOMECHANICS LA English DT Article DE Walking; Dynamic stability; Perturbations; Walking surface; Visual ID GAIT STABILITY; LATERAL STABILIZATION; LYAPUNOV EXPONENTS; OVERGROUND WALKING; MODELING APPROACH; VARIABILITY; SURFACE; SPEED; BALANCE; MOTION AB External perturbations applied to the walking surface or visual field can challenge an individual's ability to maintain stability during walking. Accurately quantifying and predicting changes in stability during walking will further our understanding of how individuals respond to challenges encountered during daily life and guide the development of assessments and rehabilitation interventions for individuals at increased risk of falling. This study is the first to determine how orbital and local dynamic stability metrics, including maximum Floquet multipliers and local divergence exponents, change in response to continuous mediolateral visual and surface perturbations of different amplitudes. Eleven healthy individuals walked in a fully immersive virtual environment. Participants completed two 3-min walking trials each under the following nine conditions: no perturbations, surface perturbations at each of 3 amplitudes, and visual perturbations at each of 5 amplitudes. All perturbations were applied as continuous pseudo-random oscillations. During both surface and visual perturbations, individuals were significantly more orbitally and locally unstable compared to un-perturbed walking. As walking surface perturbation amplitudes increased, individuals were more orbitally (but not locally) unstable. As visual perturbation amplitudes increased, individuals were more locally (but not orbitally) unstable between lower and higher amplitudes. Overall, these dynamic stability metrics were much less sensitive to changes in perturbation amplitudes than to differences between un-perturbed and perturbed walking, or to differences between mechanical and visual perturbations. This suggests that the type of perturbation(s) applied has a far greater impact than the magnitude of those perturbations in determining the response that will be elicited. (C) 2012 Elsevier Ltd. All rights reserved. C1 [Terry, Kevin; Dingwell, Jonathan B.] Univ Texas Austin, Dept Kinesiol & Hlth Educ, Austin, TX 78712 USA. [Sinitksi, Emily H.; Terry, Kevin; Wilken, Jason M.] Brooke Army Med Ctr, Dept Orthopaed & Rehabil, Ctr Intrepid, Ft Sam Houston, TX 78234 USA. RP Dingwell, JB (reprint author), Univ Texas Austin, Dept Kinesiol & Hlth Educ, Austin, TX 78712 USA. EM jdingwell@austin.utexas.edu RI Terry, Kevin/L-2760-2013; OI Terry, Kevin/0000-0001-7708-1740; Wilken, Jason/0000-0002-5556-7667; Dingwell, Jonathan/0000-0001-6990-4153 FU National Institutes of Health (NIH) [1-R01-HD059844] FX Support by National Institutes of Health (NIH) Grant 1-R01-HD059844 (to JBD and JMW). The authors also thank Michael Vernon for development and operation of the simulation environment. NR 41 TC 14 Z9 14 U1 2 U2 167 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0021-9290 J9 J BIOMECH JI J. Biomech. PD AUG 9 PY 2012 VL 45 IS 12 BP 2084 EP 2091 DI 10.1016/j.jbiomech.2012.05.039 PG 8 WC Biophysics; Engineering, Biomedical SC Biophysics; Engineering GA 994BL UT WOS:000307905800005 PM 22749389 ER PT J AU McWilliams, RS Kadry, Y Mahmood, MF Goncharov, AF Ciezak-Jenkins, J AF McWilliams, R. Stewart Kadry, Yasmin Mahmood, Mohammad F. Goncharov, Alexander F. Ciezak-Jenkins, Jennifer TI Structural and chemical properties of the nitrogen-rich energetic material triaminoguanidinium 1-methyl-5-nitriminotetrazolate under pressure SO JOURNAL OF CHEMICAL PHYSICS LA English DT Article ID DENSITY; PHASE; GPA AB The structural and chemical properties of the bi-molecular, hydrogen-bonded, nitrogen-rich energetic material triaminoguanidinium 1-methyl-5-nitriminotetrazolate C3H12N12O2 (TAG-MNT) have been investigated at room pressure and under high pressure isothermal compression using powder x-ray diffraction and Raman and infrared spectroscopy. A stiffening of the equation of state and concomitant structural relaxation between 6 and 14 GPa are found to correlate with Raman mode disappearances, frequency discontinuities, and changes in the pressure dependence of modes. These observations manifest the occurrence of a reversible martensitic structural transformation to a new crystalline phase. The onset and vanishing of Fermi resonance in the nitrimine group correlate with the stiffening of the equation of state and phase transition, suggesting a possible connection between these phenomena. Beyond 15 GPa, pressure induces irreversible chemical reactions, culminating in the formation of a polymeric phase by 60 GPa. (C) 2012 American Institute of Physics. [http://dx.doi.org/10.1063/1.4732097] C1 [McWilliams, R. Stewart; Kadry, Yasmin; Mahmood, Mohammad F.] Howard Univ, Washington, DC 20059 USA. [McWilliams, R. Stewart; Kadry, Yasmin; Mahmood, Mohammad F.; Goncharov, Alexander F.; Ciezak-Jenkins, Jennifer] Carnegie Inst Sci, Geophys Lab, Washington, DC 20015 USA. [Ciezak-Jenkins, Jennifer] USA, RDRL WML B, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP McWilliams, RS (reprint author), Howard Univ, Washington, DC 20059 USA. RI McWilliams, R./J-4358-2016 FU US Army Research Office [ARO-56122-CH-H]; US Army Research Office High School Apprenticeship Program (ARO-HSAP); Department of Energy National Nuclear Security Administration (Carnegie/DOE Alliance Center) [DE-FC52-08NA28554]; National Science Foundation - Earth Sciences [EAR-0622171]; Department of Energy - Geosciences [DE-FG02-94ER14466]; U.S. Department of Energy, Office of Science, Office of Basic Energy Sciences [DE-AC02-06CH11357]; DOE [DE-AC02-98CH10886]; COMPRES; Consortium for Materials Properties Research in Earth Sciences, under NSF Cooperative Agreement [EAR-0135554]; U.S. DOE (CDAC) [DE-FC03-03N00144] FX The authors would like to thank M. Somayazulu for experimental assistance, Vitali Prakapenka and the GSECARS staff for help in conducting synchrotron experiments, and two anonymous reviewers for comments on this manuscript. E. F. C. Byrd is thanked for his assistance in performing the quantum chemical calculations on TAG-MNT. This work was supported by the US Army Research Office (ARO-56122-CH-H), the US Army Research Office High School Apprenticeship Program (ARO-HSAP), and the Department of Energy National Nuclear Security Administration (Carnegie/DOE Alliance Center; DE-FC52-08NA28554). GSECARS is supported by the National Science Foundation - Earth Sciences (EAR-0622171) and Department of Energy - Geosciences (DE-FG02-94ER14466). Use of the Advanced Photon Source was supported by the U.S. Department of Energy, Office of Science, Office of Basic Energy Sciences, under Contract No. DE-AC02-06CH11357. Infrared measurements were performed at the U2A beamline at the NSLS of BNL (DOE Contract No. DE-AC02-98CH10886). The U2A beamline is supported by COMPRES, the Consortium for Materials Properties Research in Earth Sciences, under NSF Cooperative Agreement Grant No. EAR-0135554 and the U.S. DOE (CDAC, Contract No. DE-FC03-03N00144). NR 29 TC 9 Z9 9 U1 2 U2 25 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0021-9606 J9 J CHEM PHYS JI J. Chem. Phys. PD AUG 7 PY 2012 VL 137 IS 5 AR 054501 DI 10.1063/1.4732097 PG 12 WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical SC Chemistry; Physics GA 994HM UT WOS:000307921500036 PM 22894358 ER PT J AU Woo, HJ Reifman, J AF Woo, Hyung-June Reifman, Jaques TI A quantitative quasispecies theory-based model of virus escape mutation under immune selection SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA LA English DT Article DE population dynamics; next-generation sequencing; stochastic simulation; HIV ID RNA VIRUS; FITNESS LANDSCAPE; HIV-1; EVOLUTION; ADAPTATION; RESPONSES; TYPE-1; REPLICATION; DIVERSITY; SURVIVAL AB Viral infections involve a complex interplay of the immune response and escape mutation of the virus quasispecies inside a single host. Although fundamental aspects of such a balance of mutation and selection pressure have been established by the quasispecies theory decades ago, its implications have largely remained qualitative. Here, we present a quantitative approach to model the virus evolution under cytotoxic T-lymphocyte immune response. The virus quasispecies dynamics are explicitly represented by mutations in the combined sequence space of a set of epitopes within the viral genome. We stochastically simulated the growth of a viral population originating from a single wild-type founder virus and its recognition and clearance by the immune response, as well as the expansion of its genetic diversity. Applied to the immune escape of a simian immunodeficiency virus epitope, model predictions were quantitatively comparable to the experimental data. Within the model parameter space, we found two qualitatively different regimes of infectious disease pathogenesis, each representing alternative fates of the immune response: It can clear the infection in finite time or eventually be overwhelmed by viral growth and escape mutation. The latter regime exhibits the characteristic disease progression pattern of human immunodeficiency virus, while the former is bounded by maximum mutation rates that can be suppressed by the immune response. Our results demonstrate that, by explicitly representing epitope mutations and thus providing a genotype-phenotype map, the quasispecies theory can form the basis of a detailed sequence-specific model of real-world viral pathogens evolving under immune selection. C1 [Woo, Hyung-June; Reifman, Jaques] USA, Biotechnol High Performance Comp Software Applica, Telemed & Adv Technol Res Ctr, Med Res & Mat Command, Ft Detrick, MD 21702 USA. RP Reifman, J (reprint author), USA, Biotechnol High Performance Comp Software Applica, Telemed & Adv Technol Res Ctr, Med Res & Mat Command, Ft Detrick, MD 21702 USA. EM jaques.reifman@us.army.mil FU US Army's Network Science Initiative; US Army Assistant Secretary of the Army for Acquisition, Logistics, and Technology FX This work was sponsored by both the US Army's Network Science Initiative, managed by the Military Operational Medicine Research Program of the US Army Medical Research and Materiel Command, Fort Detrick, Maryland, and by a competitive In-House Laboratory Independent Research award by the US Army Assistant Secretary of the Army for Acquisition, Logistics, and Technology. The opinions and assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the US Army or of the US Department of Defense. This paper has been approved for public release with unlimited distribution. NR 43 TC 15 Z9 16 U1 2 U2 9 PU NATL ACAD SCIENCES PI WASHINGTON PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA SN 0027-8424 J9 P NATL ACAD SCI USA JI Proc. Natl. Acad. Sci. U. S. A. PD AUG 7 PY 2012 VL 109 IS 32 BP 12980 EP 12985 DI 10.1073/pnas.1117201109 PG 6 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 989HU UT WOS:000307551700035 PM 22826258 ER PT J AU Mohan, M Trump, BD Bates, ME Monica, JC Linkov, I AF Mohan, Mayank Trump, Benjamin D. Bates, Matthew E. Monica, John C., Jr. Linkov, Igor TI Integrating Legal Liabilities in Nanomanufacturing Risk Management SO ENVIRONMENTAL SCIENCE & TECHNOLOGY LA English DT Article ID NANOMATERIALS AB Among other things, the wide-scale development and use of nanomaterials is expected to produce costly regulatory and civil liabilities for nanomanufacturers due to lingering uncertainties, unanticipated effects, and potential toxicity. The life-cycle environmental, health, and safety (EHS) risks of nanomaterials are currently being studied, but the corresponding legal risks have not been systematically addressed. With the aid of a systematic approach that holistically evaluates and accounts for uncertainties about the inherent properties of nanomaterials, it is possible to provide an order of magnitude estimate of liability risks from regulatory and litigious sources based on current knowledge. In this work, we present a conceptual framework for integrating estimated legal liabilities with EHS risks across nanomaterial life-cycle stages using empirical knowledge in the field, scientific and legal judgment, probabilistic risk assessment, and multicriteria decision analysis. Such estimates will provide investors and operators with a basis to compare different technologies and practices and will also inform regulatory and legislative bodies in determining standards that balance risks with technical advancement. We illustrate the framework through the hypothetical case of a manufacturer of nanoscale titanium dioxide and use the resulting expected legal costs to evaluate alternative risk-management actions. C1 [Mohan, Mayank; Trump, Benjamin D.; Bates, Matthew E.; Linkov, Igor] USA, Engineer Res & Dev Ctr, Concord, MA USA. [Mohan, Mayank] Loyola Law Sch, Los Angeles, CA USA. [Linkov, Igor] Carnegie Mellon Univ, Pittsburgh, PA 15213 USA. [Monica, John C., Jr.] Porter Wright Morris & Arthur LLP, Columbus, OH USA. [Trump, Benjamin D.] Univ Michigan, Ann Arbor, MI 48109 USA. RP Linkov, I (reprint author), USA, Engineer Res & Dev Ctr, 696 Virginia Rd, Concord, MA USA. EM igor.linkov@usace.army.mil FU ERDC Nanotechnology Focus Area FX This effort was sponsored through the ERDC Nanotechnology Focus Area. Permission was granted by the USACE Chief of Engineers to publish this material. NR 28 TC 3 Z9 4 U1 1 U2 21 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0013-936X EI 1520-5851 J9 ENVIRON SCI TECHNOL JI Environ. Sci. Technol. PD AUG 7 PY 2012 VL 46 IS 15 BP 7955 EP 7962 DI 10.1021/es3003266 PG 8 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA 984OG UT WOS:000307199800008 PM 22717005 ER PT J AU Lutz, LJ Karl, JP Rood, JC Cable, SJ Williams, KW Young, AJ McClung, JP AF Lutz, Laura J. Karl, J. Philip Rood, Jennifer C. Cable, Sonya J. Williams, Kelly W. Young, Andrew J. McClung, James P. TI Vitamin D status, dietary intake, and bone turnover in female Soldiers during military training: a longitudinal study SO JOURNAL OF THE INTERNATIONAL SOCIETY OF SPORTS NUTRITION LA English DT Article DE Vitamin D; Calcium; Parathyroid hormone; Bone turnover; Soldiers ID STRESS-FRACTURES; 25-HYDROXYVITAMIN D; WHITE-CHILDREN; WOMEN; BLACK; CALCIUM; ASSOCIATION; PREVENTION; RESISTANCE; EXERCISE AB Background: Vitamin D is an essential nutrient for maintaining bone health, to include protecting against stress fracture during periods of rapid bone turnover. The objective of this longitudinal, observational study was to assess vitamin D status, biomarkers of bone turnover, and vitamin D and calcium intake in female Soldiers (n = 91) during US Army basic combat training (BCT). Methods: Anthropometric, biological and dietary intake data were collected at wk 0, 3, 6, and 9 of the 10 wk BCT course. Mixed models repeated measures ANOVAs were used to assess main effects of time, race, and time-by-race interactions. Results: White volunteers experienced a decrease in serum 25(OH) D levels, whereas non-white volunteers experienced an increase during BCT. However, serum 25(OH) D levels were lower in non-whites than whites at all timepoints (P-interaction < 0.05). Group mean PTH levels increased (P < 0.05) during the first 3 wk of training, remained elevated for the duration of BCT, and were higher in non-whites compared to whites (P-race < 0.05). Biomarkers of both bone formation (bone alkaline phosphatase and procollagen I N-terminal peptide) and resorption (tartrate-resistant acid phosphatase and C-terminal telopeptide) increased (P < 0.05) during BCT, indicating increased bone turnover. Estimated daily intakes of vitamin D and calcium were below recommended levels (15 mu g and 1000 mg/day, respectively), both before (group mean +/- SEM; 3.9 mu g/d +/- 0.4 and 887 mg/d +/- 67) and during BCT (4.1 mu g/d +/- 0.3 and 882 mg/d +/- 51). Conclusions: These findings demonstrate that female Soldiers experience dynamic changes in vitamin D status coupled with increased bone turnover and potentially inadequate vitamin D and calcium intake during military training. C1 [Lutz, Laura J.; Karl, J. Philip; Young, Andrew J.; McClung, James P.] USA, Environm Med Res Inst, Mil Nutr Div, Natick, MA 01760 USA. [Rood, Jennifer C.] Louisiana State Univ Syst, Pennington Biomed Res Ctr, Baton Rouge, LA 70808 USA. [Cable, Sonya J.; Williams, Kelly W.] Directorate Basic Combat Training, Ft Jackson, SC 29207 USA. RP McClung, JP (reprint author), USA, Environm Med Res Inst, Mil Nutr Div, Natick, MA 01760 USA. EM James.McClung3@us.army.mil RI McClung, James/A-1989-2009; OI Karl, J. Philip/0000-0002-5871-2241 FU US Army Medical Research and Material Command FX We acknowledge the Soldier volunteers that participated in this study and the Command staff at Fort Jackson, SC, who provided access to potential volunteers. Research supported by the US Army Medical Research and Material Command. The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the Army or the Department of Defense. Any citations of commercial organizations and trade names in this report do not constitute an official Department of the Army endorsement of approval of the products or services of these organizations. NR 39 TC 10 Z9 10 U1 0 U2 11 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1550-2783 J9 J INT SOC SPORT NUTR JI J. Int. Soc. Sport Nutr. PD AUG 6 PY 2012 VL 9 AR 38 DI 10.1186/1550-2783-9-38 PG 7 WC Nutrition & Dietetics; Sport Sciences SC Nutrition & Dietetics; Sport Sciences GA 993IX UT WOS:000307852800001 PM 22866974 ER PT J AU Steers, NJ Ratto-Kim, S de Souza, MS Currier, JR Kim, JH Michael, NL Alving, CR Rao, M AF Steers, Nicholas J. Ratto-Kim, Silvia de Souza, Mark S. Currier, Jeffrey R. Kim, Jerome H. Michael, Nelson L. Alving, Carl R. Rao, Mangala TI HIV-1 Envelope Resistance to Proteasomal Cleavage: Implications for Vaccine Induced Immune Responses SO PLOS ONE LA English DT Article ID T-CELL RESPONSES; ANTIGEN PRESENTATION; CLASS-II; INVARIANT CHAIN; DENDRITIC CELLS; IN-VIVO; PROTEIN; GLYCOSYLATION; DEGRADATION; GENERATION AB Background: Antigen processing involves many proteolytic enzymes such as proteasomes and cathepsins. The processed antigen is then presented on the cell surface bound to either MHC class I or class II molecules and induces/interacts with antigen-specific CD8+ and CD4+ T-cells, respectively. Preliminary immunological data from the RV144 phase III trial indicated that the immune responses were biased towards the Env antigen with a dominant CD4+ T-cell response. Methods: In this study, we examined the susceptibility of HIV-1 Env-A244 gp120 protein, one of the protein boost subunits of the RV144 Phase III vaccine trial, to proteasomes and cathepsins and identified the generated peptide epitope repertoire by mass spectrometry. The peptide fragments were tested for cytokine production in CD4(+) T-cell lines derived from RV144 volunteers. Results: Env-A244 was resistant to proteasomes, thus diminishing the possibility of the generation of class I epitopes by the classical MHC class I pathway. However, Env-A244 was efficiently cleaved by cathepsins generating peptide arrays identified by mass spectrometry that contained both MHC class I and class II epitopes as reported in the Los Alamos database. Each of the cathepsins generated distinct degradation patterns containing regions of light and dense epitope clusters. The sequence DKKQKVHALF that is part of the V2 loop of gp120 produced by cathepsins induced a polyfunctional cytokine response including the generation of IFN-gamma from CD4(+) T-cell lines-derived from RV144 vaccinees. This sequence is significant since antibodies to the V1/V2-loop region correlated inversely with HIV-1 infection in the RV144 trial. Conclusions: Based on our results, the susceptibility of Env-A244 to cathepsins and not to proteasomes suggests a possible mechanism for the generation of Env-specific CD4(+)T cell and antibody responses in the RV144 vaccinees. C1 [Steers, Nicholas J.; Ratto-Kim, Silvia; Currier, Jeffrey R.; Kim, Jerome H.; Michael, Nelson L.; Alving, Carl R.; Rao, Mangala] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD USA. [Steers, Nicholas J.; Ratto-Kim, Silvia; Currier, Jeffrey R.] Henry M Jackson Fdn Adv Mil Med, Bethesda, MD USA. [de Souza, Mark S.] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. RP Steers, NJ (reprint author), Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD USA. EM mrao@hivresearch.org FU Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. [W81XWH-07-2-0067]; U.S. Department of Defense (DOD) [W81XWH-07-2-0067] FX This work was supported by a cooperative agreement (W81XWH-07-2-0067) between the Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., and the U.S. Department of Defense (DOD). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 54 TC 10 Z9 10 U1 0 U2 4 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD AUG 6 PY 2012 VL 7 IS 8 AR e42579 DI 10.1371/journal.pone.0042579 PG 18 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 992WD UT WOS:000307810000049 PM 22880042 ER PT J AU Clarkson, ED Schulz, SM Railer, RF Smith, KH AF Clarkson, Edward D. Schulz, Susan M. Railer, Roy F. Smith, Kelly H. TI Median lethal dose determination for percutaneous exposure to soman and VX in guinea pigs and the effectiveness of decontamination with M291 SDK or SANDIA foam SO TOXICOLOGY LETTERS LA English DT Article DE Soman; GD; VX; Cutaneous; Decontamination; M291 SDK; SANDIA foam; MDF-100 ID SKIN; PROTECTION; TOXICITY AB Soman (GD) and VX are chemical warfare agents that can be absorbed through the skin. We determined the median lethal dose (MLD) for the cutaneous application of GD and VX in anesthetized haired guinea pigs and then tested the ability of a currently fielded decontamination kit, the M291 Skin Decontamination Kit (SDK), and decontaminating foam made by SANDIA Labs to decontaminate areas that have been exposed to cutaneous applications of GD and VX. The fur of guinea pigs was clipped on the left flank 24 h prior to exposure. Animals were anesthetized and 5 min later neat GD or neat VX was applied. The MLD for percutaneous exposure to GD was 11.6 mg/kg, and to VX it was 0.10 mg/kg. To test the ability of the M291 SDK. either GD or VX was applied and removed 1 min later with the pads of the M291 SDK clasped in a pair of forceps and wiped across the flank of the animal. The MLDs for GD and VX removed with the M291 SDK pads were 76.9 mg/kg and 0.87 mg/kg, respectively. When neat GD or neat VX was applied and removed 1 min later in the same manner with gauze soaked in SANDIA foam (MDF-100), the MLDs were 412 mg/kg and 10.4 mg/kg respectively. These data demonstrate that GD and VX are significantly less potent when applied cutaneously than previously reported for subcutaneous injections and indicate that improvement is needed on the limited protective ratio provided by the M291 SDK. Published by Elsevier Ireland Ltd. C1 [Clarkson, Edward D.; Schulz, Susan M.; Railer, Roy F.; Smith, Kelly H.] USA, Med Res Inst Chem Def, ATTN MCMR CDT T, Aberdeen Proving Ground, MD 21010 USA. RP Clarkson, ED (reprint author), USA, Med Res Inst Chem Def, ATTN MCMR CDT T, 3100 Ricketts Pt Rd, Aberdeen Proving Ground, MD 21010 USA. EM Edward.D.Clarkson@US.Army.Mil FU Defense Threat Reduction Agency - Joint Science and Technology Office, Medical ST Division FX The authors wish to thank Modec Inc., Denver, Colorado for the donation of MDF-100. This research was supported by the Defense Threat Reduction Agency - Joint Science and Technology Office, Medical S&T Division. The views expressed in this article are those of the author(s) and do not reflect the official policy of the Department of Army, Department of Defense, or the U.S. Government. The experimental protocol was approved by the Animal Care and Use Committee at the United States Army Medical Research Institute of Chemical Defense and all procedures were conducted in accordance with the principles stated in the Guide for the Care and Use of Laboratory Animals (National Research Council, 2011), and the Animal Welfare Act of 1966 (P.L. 89-544), as amended. NR 23 TC 1 Z9 1 U1 0 U2 8 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0378-4274 J9 TOXICOL LETT JI Toxicol. Lett. PD AUG 3 PY 2012 VL 212 IS 3 BP 282 EP 287 DI 10.1016/j.toxlet.2012.05.028 PG 6 WC Toxicology SC Toxicology GA 990GN UT WOS:000307619100007 PM 22698813 ER PT J AU Liang, T Devine, B Phillpot, SR Sinnott, SB AF Liang, Tao Devine, Bryce Phillpot, Simon R. Sinnott, Susan B. TI Variable Charge Reactive Potential for Hydrocarbons to Simulate Organic-Copper Interactions SO JOURNAL OF PHYSICAL CHEMISTRY A LA English DT Article ID EMBEDDED-ATOM METHOD; MOLECULAR-DYNAMICS SIMULATIONS; CHEMICAL-VAPOR-DEPOSITION; AUGMENTED-WAVE METHOD; EQUATION-OF-STATE; FORCE-FIELD; AB-INITIO; ELASTIC CONSTANTS; OXIDE SYSTEMS; SILICON AB A variable charge reactive empirical potential for carbon-based materials, hydrocarbons, organometallics, and their interfaces is developed within the framework of charge optimized many-body (COMB) potentials. The resulting potential contains improved expressions for the bond order and self-energy, which gives a flexible, robust, and integrated treatment of different bond types in multicomponent and multifunctional systems. It furthermore captures the dissociation and formation of the chemical bonds and appropriately and dynamically determines the associated charge transfer, thus providing a powerful method to simulate the complex chemistry of many-atom systems in changing environments. The resulting COMB potential is used in a classical molecular dynamics simulation of the room temperature, low energy deposition of ethyl radicals on the Cu (111) surface (a system with similar to 5000 atoms) to demonstrate its capabilities at describing organic-metal interactions in a dynamically changing environment. C1 [Liang, Tao; Phillpot, Simon R.; Sinnott, Susan B.] Univ Florida, Dept Mat Sci & Engn, Gainesville, FL 32611 USA. [Devine, Bryce] USA, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Sinnott, SB (reprint author), Univ Florida, Dept Mat Sci & Engn, Gainesville, FL 32611 USA. EM ssinn@mse.ufl.edu RI Phillpot, Simon/J-9117-2012; Sinnott, Susan/P-8523-2014; OI Sinnott, Susan/0000-0002-3598-0403; Phillpot, Simon/0000-0002-7774-6535 FU National Science Foundation [CHE-0809376]; Consortium for Advanced Simulation of Light Water Reactors; U.S. Department of Energy [DE-AC05-00OR22725] FX T.L., B.D., and S.B.S. gratefully acknowledge the support of the National Science Foundation (CHE-0809376). The work of S.R.P. was supported by the Consortium for Advanced Simulation of Light Water Reactors (www.casl.gov), an Energy Innovation Hub (http://www.energy.gov/hubs) for Modeling and Simulation of Nuclear Reactors under U.S. Department of Energy Contract No. DE-AC05-00OR22725. NR 85 TC 30 Z9 30 U1 0 U2 47 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1089-5639 J9 J PHYS CHEM A JI J. Phys. Chem. A PD AUG 2 PY 2012 VL 116 IS 30 BP 7976 EP 7991 DI 10.1021/jp212083t PG 16 WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical SC Chemistry; Physics GA 981RZ UT WOS:000306988700024 PM 22738218 ER PT J AU Pybus, BS Sousa, JC Jin, XN Ferguson, JA Christian, RE Barnhart, R Vuong, C Sciotti, RJ Reichard, GA Kozar, MP Walker, LA Ohrt, C Melendez, V AF Pybus, Brandon S. Sousa, Jason C. Jin, Xiannu Ferguson, James A. Christian, Robert E. Barnhart, Rebecca Vuong, Chau Sciotti, Richard J. Reichard, Gregory A. Kozar, Michael P. Walker, Larry A. Ohrt, Colin Melendez, Victor TI CYP450 phenotyping and accurate mass identification of metabolites of the 8-aminoquinoline, anti-malarial drug primaquine SO MALARIA JOURNAL LA English DT Article ID INDUCED HEMOLYTIC-ANEMIA; MONOAMINE-OXIDASE; PHARMACOKINETICS; ERYTHROCYTES; MALARIA; CYP2D6 AB Background: The 8-aminoquinoline (8AQ) drug primaquine (PQ) is currently the only approved drug effective against the persistent liver stage of the hypnozoite forming strains Plasmodium vivax and Plasmodium ovale as well as Stage V gametocytes of Plasmodium falciparum. To date, several groups have investigated the toxicity observed in the 8AQ class, however, exact mechanisms and/or metabolic species responsible for PQ's haemotoxic and antimalarial properties are not fully understood. Methods: In the present study, the metabolism of PQ was evaluated using in vitro recombinant metabolic enzymes from the cytochrome P450 (CYP) and mono-amine oxidase (MAO) families. Based on this information, metabolite identification experiments were performed using nominal and accurate mass measurements. Results: Relative activity factor ( RAF)-weighted intrinsic clearance values show the relative role of each enzyme to be MAO-A, 2C19, 3A4, and 2D6, with 76.1, 17.0, 5.2, and 1.7% contributions to PQ metabolism, respectively. CYP 2D6 was shown to produce at least six different oxidative metabolites along with demethylations, while MAO-A products derived from the PQ aldehyde, a pre-cursor to carboxy PQ. CYPs 2C19 and 3A4 produced only trace levels of hydroxylated species. Conclusions: As a result of this work, CYP 2D6 and MAO-A have been implicated as the key enzymes associated with PQ metabolism, and metabolites previously identified as potentially playing a role in efficacy and haemolytic toxicity have been attributed to production via CYP 2D6 mediated pathways. C1 [Pybus, Brandon S.; Sousa, Jason C.; Jin, Xiannu; Barnhart, Rebecca; Vuong, Chau; Sciotti, Richard J.; Reichard, Gregory A.; Kozar, Michael P.; Ohrt, Colin; Melendez, Victor] Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. [Ferguson, James A.; Christian, Robert E.] AB Sciex, Framingham, MA 01701 USA. [Walker, Larry A.] Univ Mississippi, Sch Pharm, Natl Ctr Nat Prod Res, Oxford, MS 38677 USA. RP Pybus, BS (reprint author), Walter Reed Army Inst Res, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM brandon.pybus@us.army.mil RI Sousa, Jason/A-9177-2011; Sciotti, Richard/A-9069-2011; Kozar, Michael/A-9155-2011 FU University of Mississippi; US Army Medical Research & Materiel Command (USAMRMC); Telemedicine & Advanced Technology Research Center (TATRC), at Fort Detrick, MD [W81-XWH-07-2-0095] FX This research and development project is supported by a grant to the University of Mississippi, and was awarded and administered by the US Army Medical Research & Materiel Command (USAMRMC) and the Telemedicine & Advanced Technology Research Center (TATRC), at Fort Detrick, MD, under award number: W81-XWH-07-2-0095. The views, opinions and/or findings contained in this presentation are those of the author(s) and do not necessarily reflect the views of the Department of Defense and should not be construed as an official DoD/Army position, policy or decision unless so designated by other documentation. No official endorsement should be made. NR 19 TC 37 Z9 37 U1 0 U2 17 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1475-2875 J9 MALARIA J JI Malar. J. PD AUG 2 PY 2012 VL 11 AR 259 DI 10.1186/1475-2875-11-259 PG 9 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA 002OK UT WOS:000308541300001 PM 22856549 ER PT J AU He, H Lei, YK Xiao, C Chu, DR Chen, RR Wang, GF AF He, Hui Lei, Yinkai Xiao, Chan Chu, Deryn Chen, Rongrong Wang, Guofeng TI Molecular and Electronic Structures of Transition-Metal Macrocyclic Complexes as Related to Catalyzing Oxygen Reduction Reactions: A Density Functional Theory Study SO JOURNAL OF PHYSICAL CHEMISTRY C LA English DT Article ID METHANOL FUEL-CELLS; COBALT PHTHALOCYANINE; IRON PHTHALOCYANINE; O-2 REDUCTION; CARBON-BLACK; ELECTROCATALYSTS; PORPHYRINS; CATALYSTS; STEREOCHEMISTRY; CATHODE AB Transition-metal (TM) macrocyclic complexes have potential applications as nonprecious electrocatalysts in polymer electrolyte membrane fuel cells. In this study, we employed density functional theory calculation methods to predict the molecular and electronic structures of O-2, OH, and H2O2 molecules adsorbed on TM porphyrins, TM tetraphenylporphyrins, TM phthalocyanines, TM fluorinated phthalocyanines, and TM chlorinated phthalocyanines (here TM = Fe or Co). Relevant to their performance on catalyzing oxygen reduction reaction (ORR), we found for the studied TM macrocyclic complexes: (1) The type of the central TM is the most determinant factor in influencing the adsorption energies of O-2, OH, and H2O2 (chemical species involved in ORR) molecules on these macrocyclic complexes. Specifically, the calculated adsorption energies of O-2, OH, and H2O2 on the Fe macrocyclic complexes are always distinguishably lower than those on the Co macrocyclic complexes. (2) The peripheral ligands are capable of modulating the binding strength among the adsorbed O-2, OH, and H2O2, and the TM macrocyclic complexes. (3) A N-TM-N cluster structure (like N-Fe-N) with a proper distance between the two ending N atoms and a strong electronic interaction among the three atoms is required to break the O-O bond and thus promote the efficient four-electron pathway of the ORR on the TM macrocyclic complexes. C1 [He, Hui; Chen, Rongrong] Indiana Univ Purdue Univ, Richard G Lugar Ctr Renewable Energy, Indianapolis, IN 46202 USA. [Xiao, Chan] Indiana Univ Purdue Univ, Dept Mech Engn, Indianapolis, IN 46202 USA. [Lei, Yinkai; Wang, Guofeng] Univ Pittsburgh, Dept Mech Engn & Mat Sci, Pittsburgh, PA 15261 USA. [Chu, Deryn] USA, Res Lab, Adelphi, MD 20783 USA. RP Chen, RR (reprint author), Indiana Univ Purdue Univ, Richard G Lugar Ctr Renewable Energy, Indianapolis, IN 46202 USA. EM rochen@iupui.edu; guw8@pitt.edu OI Lei, Yinkai/0000-0002-0200-1491 FU Chemical Sciences Research Programs, Office of Basic Energy Sciences, U.S. Department of Energy [DE-FG02-09ER16093]; EERE program of U.S. Department of Energy [DE-AC02-06CH11357]; U.S. Army Research Lab [W911NF-10-2-0075] FX Y.L. and C.X. were funded by Chemical Sciences Research Programs, Office of Basic Energy Sciences, U.S. Department of Energy (grant no. DE-FG02-09ER16093). G.W. also acknowledges the research grants from EERE program of U.S. Department of Energy (grant no. DE-AC02-06CH11357). H.H. and RC. were supported by the U.S. Army Research Lab (grant no. W911NF-10-2-0075). NR 29 TC 36 Z9 37 U1 5 U2 90 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1932-7447 J9 J PHYS CHEM C JI J. Phys. Chem. C PD AUG 2 PY 2012 VL 116 IS 30 BP 16038 EP 16046 DI 10.1021/jp303312r PG 9 WC Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary SC Chemistry; Science & Technology - Other Topics; Materials Science GA 981SH UT WOS:000306989500021 ER PT J AU de Rosset, WS AF de Rosset, William S. TI Gun Liner Emplacement SO JOURNAL OF PRESSURE VESSEL TECHNOLOGY-TRANSACTIONS OF THE ASME LA English DT Article AB The development of a process to emplace a refractory metal liner inside a gun tube is described. The process consists of filling the liner with an elastomeric material and then slipping this arrangement into the gun tube. The ends of the liner are plugged with plastic disks and pressure is applied to the elastomeric material by a load frame. Plastic deformation of the gun tube results in residual radial stresses that induce a frictional bond between the liner and gun tube. Efforts are described to increase the bond strength through increasing the coefficient of friction. [DOI: 10.1115/1.4007008] C1 USA, Dynam Sci Inc, Res Lab, ATTN RDRL WMM F, Aberdeen Proving Ground, MD 21005 USA. RP de Rosset, WS (reprint author), USA, Dynam Sci Inc, Res Lab, ATTN RDRL WMM F, Aberdeen Proving Ground, MD 21005 USA. EM william.s.derosset.ctr@mail.mil NR 1 TC 0 Z9 0 U1 0 U2 2 PU ASME PI NEW YORK PA TWO PARK AVE, NEW YORK, NY 10016-5990 USA SN 0094-9930 J9 J PRESS VESS-T ASME JI J. Press. Vessel Technol.-Trans. ASME PD AUG PY 2012 VL 134 IS 4 AR 041009 DI 10.1115/1.4007008 PG 5 WC Engineering, Mechanical SC Engineering GA 103TG UT WOS:000315941200010 ER PT J AU Littlefield, AG Hyland, EJ AF Littlefield, Andrew G. Hyland, Edward J. TI 120 mm Prestressed Carbon Fiber/Thermoplastic Overwrapped Gun Tubes SO JOURNAL OF PRESSURE VESSEL TECHNOLOGY-TRANSACTIONS OF THE ASME LA English DT Article AB The emphasis on lightweight large caliber weapons systems has placed the focus on the use of advanced composite materials. Using composite materials not only directly removes weight from the gun tube but also, by better balancing the tube, allows the use of smaller drive systems, thus further enhancing the system weight loss. Additionally, the use of high stiffness composites helps with pointing accuracy and to alleviate the dynamic strain phenomenon encountered with high velocity projectiles. Traditionally, there were two issues with composite jackets: the coefficient of thermal expansion mismatch between the steel substrate and the composite jacket causing a gap and the lack of favorable prestress in the jacket. Dealing with these issues greatly complicated the manufacturing process to the point where mass-producing the barrels would have been problematic at best. By using a thermoplastic resin, a cure on the fly process, and winding under tension, the manufacturability of the barrels has been greatly improved, the gap has been eliminated, and a favorable prestress has been achieved. Four 120 mm barrels have been manufactured using this process with IM7 fibers in a PEEK matrix and successfully test fired. The first barrel was not prestressed and was reported on previously. This paper will focus on the other three barrels. The design, manufacturing, and test firing of these barrels will be covered. [DOI: 10.1115/1.4007007] C1 [Littlefield, Andrew G.; Hyland, Edward J.] USA, RDECOM ARDEC Benet Labs, Watervliet, NY 12189 USA. RP Littlefield, AG (reprint author), USA, RDECOM ARDEC Benet Labs, Watervliet, NY 12189 USA. EM andrew.littlefield@us.army.mil; edward.hyland@us.army.mil NR 7 TC 1 Z9 1 U1 1 U2 7 PU ASME PI NEW YORK PA TWO PARK AVE, NEW YORK, NY 10016-5990 USA SN 0094-9930 J9 J PRESS VESS-T ASME JI J. Press. Vessel Technol.-Trans. ASME PD AUG PY 2012 VL 134 IS 4 AR 041008 DI 10.1115/1.4007007 PG 9 WC Engineering, Mechanical SC Engineering GA 103TG UT WOS:000315941200009 ER PT J AU Parker, AP Troiano, E Underwood, JH AF Parker, Anthony P. Troiano, Edward Underwood, John H. TI Impact of Intensity of Residual Stress Field Upon Reyielding and Re-Autofrettage of an Autofrettaged Thick Cylinder SO JOURNAL OF PRESSURE VESSEL TECHNOLOGY-TRANSACTIONS OF THE ASME LA English DT Article ID STEELS AB Re-autofrettage has been identified as a significant, cost-effective method to achieve higher reyield pressure (RYP) and/or weight reduction in large caliber gun tubes. For a given overstrain, residual stress profiles for hydraulic and swage autofrettage may differ significantly in their intensity. The simplest representation of this "intensity" effect is the magnitude of the bending moment "locked in" via the residual hoop stress. Hill's analytical, plane strain, Von Mises analysis predicts a larger "locked-in" moment than does the equivalent open-end condition. By assuming a range of stress-field intensities (f) scaling from 1.0 to 1.4 times that were produced by open-end hydraulic autofrettage, it was possible to assess reyield behavior following initial autofrettage via a generic numerical study. In cases where Bauschinger effect is absent, reyield initiates at the original elastic-plastic interface. This includes the ideal Hill distribution. When Bauschinger effect is present, reyield for f <= 1.1 initiates at the bore and after further pressurization at the original elastic-plastic interface within two zones. For f >= 1.2, the reverse is the case, with initial yield at the original elastic-plastic interface and subsequently at the bore. RYP increases with increasing f up to f=1.175 and then decreases significantly. This loss of RYP may be mitigated by hydraulic re-autofrettage. At f=1.0 re-autofrettage increases RYP by 4%. At f=1.4, RYP is increased by 19%. There are modest increases in safe maximum pressure (SMP) as a result of re-autofrettage. RYP closely approaching re-autofrettage pressure is achievable for f >= 1.3. Within this range, re-autofrettage offers a significant benefit. Re-autofrettage also produces beneficial effects via increased bore hoop compressive stress, this increase varying from 20% for f=1% to 0% for f=1.4. Such increased compression will benefit fatigue lifetime for fatigue cracks initiating at the bore. Conversely, tensile outside diameter (OD) hoop stress increases, with increasing f, by a maximum of 6%. [DOI: 10.1115/1.4006349] C1 [Parker, Anthony P.] Cranfield Univ, Def Acad United Kingdom, Swindon SN6 8LA, Wilts, England. [Troiano, Edward] USA, WS&T Ctr, Benet Labs, Watervliet, NY 12189 USA. [Underwood, John H.] Battelle Sci Serv, Watervliet, NY 12189 USA. RP Parker, AP (reprint author), Cranfield Univ, Def Acad United Kingdom, Swindon SN6 8LA, Wilts, England. EM parker.ETR@tiscali.co.uk; edward.troiano@us.army.mil; treaclemine@hughes.net FU US Army Armament, Research, Development and Engineering Center, Watervliet, NY; European Research Office of the US Army Research, Development and Standardization Group (UK) FX One of the authors (A.P.P.) gratefully acknowledges the support from the US Army Armament, Research, Development and Engineering Center, Watervliet, NY and from the European Research Office of the US Army Research, Development and Standardization Group (UK). NR 14 TC 0 Z9 0 U1 1 U2 2 PU ASME PI NEW YORK PA TWO PARK AVE, NEW YORK, NY 10016-5990 USA SN 0094-9930 J9 J PRESS VESS-T ASME JI J. Press. Vessel Technol.-Trans. ASME PD AUG PY 2012 VL 134 IS 4 AR 041003 DI 10.1115/1.4006349 PG 4 WC Engineering, Mechanical SC Engineering GA 103TG UT WOS:000315941200004 ER PT J AU Parker, AP Troiano, E Underwood, JH AF Parker, Anthony P. Troiano, Edward Underwood, John H. TI Stress and Stress Intensity Factor Near Notches in Thick Cylinders SO JOURNAL OF PRESSURE VESSEL TECHNOLOGY-TRANSACTIONS OF THE ASME LA English DT Article ID FATIGUE LIFE; WALLED CYLINDER; EROSIONS; CRACKS; TUBES AB This work investigates the impact of semi-elliptical notches (erosion grooves) at the bore of pressurized and autofrettaged thick cylinders. It provides a robust yet rapid method to determine the rapidly varying stress in the near-notch region prior to crack development and crack tip stress intensity factor after a crack develops at the notch root. The procedure involves a sequence of asymptotic solutions and adjustments. A superposition is presented for the stress concentration factor (SCF) of a small edge notch in a pressurized cylinder with bore pressure infiltrating and acting upon the notch surface. A procedure for adjusting this SCF to account for a varying pre-existing stress field is described. This provides accurate predictions for notch depths of up to 15% of wall thickness. Stress variation beyond the notch root is determined by scaling analytic solutions. Solution accuracy appears to be approximately 5%. Stress profiles were used to calculate stress intensity factor (SIF) for cracks emanating from the notch root and deep into the wall. There are notable differences between SIF behavior in the pressurized tube and in the autofrettaged tube. The main reason for this difference is that compressive reyielding near the notch disrupts the residual compressive stress profile over an extended distance. This leads to the conclusion that a crack originating from a notch in an autofrettaged tube exhibits a much higher cyclic SIF range during pressurization than the same length crack originating from the bore. This will cause higher fatigue crack growth rates and shorter fatigue lifetimes. [DOI: 10.1115/1.4006348] C1 [Parker, Anthony P.] Cranfield Univ, Def Acad United Kingdom, Swindon SN6 8LA, Wilts, England. [Troiano, Edward] USA, WS&T Ctr, Benet Labs, Watervliet, NY 12189 USA. [Underwood, John H.] Battelle Sci Serv, Watervliet, NY 12189 USA. RP Parker, AP (reprint author), Cranfield Univ, Def Acad United Kingdom, Swindon SN6 8LA, Wilts, England. EM parker.ETR@tiscali.co.uk; edward.troiano@us.army.mil; treaclemine@hughes.net FU US Army Armament, Research, Development and Engineering Center, Watervliet, NY; European Research Office of the US Army Research, Development and Standardization Group (UK) FX One of the authors (A.P.P.) gratefully acknowledges support from the US Army Armament, Research, Development and Engineering Center, Watervliet, NY and from the European Research Office of the US Army Research, Development and Standardization Group (UK). NR 21 TC 0 Z9 0 U1 1 U2 6 PU ASME PI NEW YORK PA TWO PARK AVE, NEW YORK, NY 10016-5990 USA SN 0094-9930 J9 J PRESS VESS-T ASME JI J. Press. Vessel Technol.-Trans. ASME PD AUG PY 2012 VL 134 IS 4 AR 041002 DI 10.1115/1.4006348 PG 7 WC Engineering, Mechanical SC Engineering GA 103TG UT WOS:000315941200003 ER PT J AU Parker, AP Gibson, MC Hameed, A Troiano, E AF Parker, Anthony P. Gibson, Michael C. Hameed, Amer Troiano, Edward TI Material Modeling for Autofrettage Stress Analysis Including the "Single Effective Material" SO JOURNAL OF PRESSURE VESSEL TECHNOLOGY-TRANSACTIONS OF THE ASME LA English DT Article ID RESIDUAL-STRESS; BAUSCHINGER; STEELS; TUBES AB Analytical and numerical stress analyses of the autofrettage process have made great strides in the last few years. The major challenge is no longer the stress analysis process but the incorporation of "real" material behavior, including Bauschinger effect. This means that material properties may vary at every radial location within the tube. In this paper, it is demonstrated that finite element analysis (FEA) may be accomplished using a "user programmable feature (UPF)" within a nonlinear FEA or, more simply using an elastic modulus and Poisson's ratio adjustment procedure (EMPRAP) within a linear-effective FEA. The results of these two methods are shown to be in agreement with each other and with an independent numerical analysis. It is further demonstrated that the numerical solutions may be obtained using a single "fictitious" material. This is called a single effective material (SEMAT). While this requires a very small number of iterations for accurate convergence, it dramatically reduces the material-modeling challenges. Furthermore, SEMAT may be implemented into an analytical procedure thereby permitting highly accurate modeling of a real material whose unloading behavior varies with radius. Comparisons indicate that this is a robust, accurate procedure. [DOI: 10.1115/1.4006351] C1 [Parker, Anthony P.; Gibson, Michael C.; Hameed, Amer] Cranfield Univ, Def Acad United Kingdom, Swindon SN6 8LA, Wilts, England. [Troiano, Edward] USA, WS&T Ctr, Benet Labs, Watervliet, NY 12189 USA. RP Parker, AP (reprint author), Cranfield Univ, Def Acad United Kingdom, Swindon SN6 8LA, Wilts, England. EM parker.ETR@tiscali.co.uk; m.c.gibson@cranfield.ac.uk; a.hameed@cranfield.ac.uk; edward.troiano@us.army.mil OI Gibson, Michael/0000-0002-7534-8701 FU US Army Armament, Research, Development and Engineering Center, Watervliet, New York; European Research Office of the US Army Research, Development and Standardization Group, United Kingdom FX The first author gratefully acknowledges the support from the US Army Armament, Research, Development and Engineering Center, Watervliet, New York and from the European Research Office of the US Army Research, Development and Standardization Group, United Kingdom. NR 19 TC 0 Z9 0 U1 0 U2 2 PU ASME PI NEW YORK PA TWO PARK AVE, NEW YORK, NY 10016-5990 USA SN 0094-9930 J9 J PRESS VESS-T ASME JI J. Press. Vessel Technol.-Trans. ASME PD AUG PY 2012 VL 134 IS 4 AR 041004 DI 10.1115/1.4006351 PG 7 WC Engineering, Mechanical SC Engineering GA 103TG UT WOS:000315941200005 ER PT J AU Trexler, MD Carter, R Champagne, VK AF Trexler, Matthew D. Carter, Robert Champagne, Victor K. TI Cold Sprayed Liners for Gun Tubes SO JOURNAL OF PRESSURE VESSEL TECHNOLOGY-TRANSACTIONS OF THE ASME LA English DT Article ID COATINGS AB The use of refractory materials is currently being developed for gun barrel coatings and liners. Explosive cladding, as well as a novel gun liner emplacement with elastomeric material (GLEEM) technique has been shown to be a successful method for bonding liners into 25-mm M242 Bushmaster barrels. The process relies on commercially available tube products that serve as the liner materials that are often difficult to manufacture. Cold spray is a novel process used to consolidate metal powders into both thin coatings and large bulk materials that is being investigated as a cost effective alternative to conventional processing techniques. This work examines the use of cold spray as it pertains to the consolidation of Ta donor tubes for explosively bonded gun liners. Ta tubes were consolidated and annealed to increase the ductility of the material from 0.2% to 35% strain as determined by tensile testing. Ta donor tube was successfully explosively clad to 25 mm gun barrel forging. Bond strength testing results of explosively clad cold spray tube were found to be comparable to commercially obtained liners. GLEEM was also successfully employed. However, the mechanical bond strength of this cladding was considerably lower than that of the explosively clad liner. The failure mechanism during GLEEM is slip between the liner and the forging and is due to the fact that the process relies on frictional bonding rather than metallurgical bonding. [DOI: 10.1115/1.4006128] C1 [Trexler, Matthew D.; Carter, Robert; Champagne, Victor K.] USA, Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. RP Trexler, MD (reprint author), USA, Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. NR 12 TC 0 Z9 0 U1 2 U2 16 PU ASME PI NEW YORK PA TWO PARK AVE, NEW YORK, NY 10016-5990 USA SN 0094-9930 J9 J PRESS VESS-T ASME JI J. Press. Vessel Technol.-Trans. ASME PD AUG PY 2012 VL 134 IS 4 AR 041010 DI 10.1115/1.4006128 PG 4 WC Engineering, Mechanical SC Engineering GA 103TG UT WOS:000315941200011 ER PT J AU Troiano, E Underwood, JH Venter, AM Izzo, JH Norray, JM AF Troiano, E. Underwood, J. H. Venter, A. M. Izzo, J. H. Norray, J. M. TI Improved Finite Element Model to Predict the Reverse Loading Behavior of Autofrettaged A723 and HB7 Cylinders SO JOURNAL OF PRESSURE VESSEL TECHNOLOGY-TRANSACTIONS OF THE ASME LA English DT Article ID STEELS AB Ideal isotropic or kinematic hardening is often utilized in order to simplify the modeling of the loading and reverse loading behavior of materials when using finite element analysis. Unfortunately, this simplification can result in significant error if the material exhibits the Bauschinger effect (BE), which is the loss of strength of the material upon reverse loading. The error associated with this simplification is further compounded in heavily autofrettaged, Cr-Mo-V, thick walled cylinders due to the fact that the Bauschinger effect and the reverse loading strain hardening exponent are a strong function of the initial applied plastic strains, which can vary significantly throughout the wall of the cylinder. [DOI: 10.1115/1.4006603] C1 [Troiano, E.; Izzo, J. H.; Norray, J. M.] USA, Benet Labs, Watervliet, NY 12189 USA. [Underwood, J. H.] Battelle Sci Serv, Watervliet, NY 12189 USA. [Venter, A. M.] Nesca Ltd, ZA-0001 Pretoria, South Africa. RP Troiano, E (reprint author), USA, Benet Labs, Watervliet, NY 12189 USA. EM edward.j.troiano.civ@mail.mil; john.h.underwood.ctr@mail.mil; andrew.venter@necsa.co.za; john.h.izzo.civ@mail.mil; john.m.norray.civ@mail.mil NR 6 TC 0 Z9 0 U1 0 U2 1 PU ASME PI NEW YORK PA TWO PARK AVE, NEW YORK, NY 10016-5990 USA SN 0094-9930 J9 J PRESS VESS-T ASME JI J. Press. Vessel Technol.-Trans. ASME PD AUG PY 2012 VL 134 IS 4 AR 041012 DI 10.1115/1.4006603 PG 4 WC Engineering, Mechanical SC Engineering GA 103TG UT WOS:000315941200013 ER PT J AU Malasavage, NE Jagupilla, S Grubb, DG Wazne, M Coon, WP AF Malasavage, Nicholas E. Jagupilla, Santhi Grubb, Dennis G. Wazne, Mahmoud Coon, William P. TI Geotechnical Performance of Dredged Material-Steel Slag Fines Blends: Laboratory and Field Evaluation SO JOURNAL OF GEOTECHNICAL AND GEOENVIRONMENTAL ENGINEERING LA English DT Article DE Field tests; Recycling; Slag; Dredge spoils; Physical properties; Soil mixing; Embankment; Cone penetration tests ID CRUSHED GLASS; HYDRAULIC CONDUCTIVITY; BLAST-FURNACE; CLAY AB This paper contains the results of a combined laboratory and field demonstration project exploring the use of dredged material (DM) blended with steel slag fines [SSF; 9.5 mm (3/8 in :) minus] as synthetic fill materials. The granular nature [a well graded sand (SW) soil], mineralogy, reactivity, and residual lime content of the SSF media make it well suited for blending with DM high-plasticity organic (OH) soil, so that geotechnical and environmental soil improvement occur simultaneously with one amendment. The source materials (100% DM, 100% SSF) were evaluated along with 80/20, 60/40, 50/50, 40/60, and 20/80 DM-SSF blends (dry weight basis), where the DM content is reported first. Key findings include that the 100% DM had a phi(CI (U) over bar)' of 27.3 degrees, which increased to a peak phi(CI (U) over bar)' value of 45 degrees for the 50/50 DM-SSF blend. The hydraulic conductivity (k) of the 100% DM(10(-8) cm/s) remained relatively constant until SSF content reached 80%, where an abrupt increase to 10(-5) cm/s was observed. The field demonstration project confirmed that the DM-SSF blends could be easily blended to within +/- 5% of their target DM content. Trial highway embankments were constructed with 100% DM, 100% SSF, and the 80/20, 50/50, and 20/80 DM-SSF blends to modified Proctor compaction goals ranging from 85 to 95% relative compaction on the maximum dry unit weight, depending on the blend. The average cone penetration test (CPT) tip resistance for 100% DM and 100% SSF media were approximately 1.3 and 57.3 MPa, respectively. The compacted 80/20, 50/50, and 20/80 DM-SSF blend embankments were generally characterized by average CPT tip resistances on the order of 2.9, 6.2, and 11.6 MPa, respectively. DOI: 10.1061/(ASCE)GT.1943-5606.0000658. (C) 2012 American Society of Civil Engineers. C1 [Malasavage, Nicholas E.] USA, Corps Engineers, San Francisco, CA 94103 USA. [Jagupilla, Santhi; Wazne, Mahmoud; Coon, William P.] Stevens Inst Technol, Dept Civil & Environm Engn, Hoboken, NJ 07030 USA. [Grubb, Dennis G.] CETCO, Trevose, PA 19053 USA. RP Malasavage, NE (reprint author), USA, Corps Engineers, 1455 Market St, San Francisco, CA 94103 USA. EM nicholas.e.malasavage@usace.army.mil FU Maryland Port Administration (Baltimore, Maryland) [270025-S-1] FX The Maryland Port Administration (Baltimore, Maryland) provided the resources and the dredged material to support this research under Contract No. 270025-S-1, "Innovative Reuse of Dredged Material" to Schnabel Engineering (West Chester, Pennsylvania), the prior affiliation for Drs. Malasavage and Grubb. Frank Hamons and Bill Lear (MPA) are thanked for their support and involvement. The SSF media were provided by Phoenix Services, LLC, Kennett Square, PA (Terry Wagaman). Maryland Environmental Services (MES) facilitated collection of the DM from the Cox Creek DMCF. The geotechnical experiments that produced the results in Tables 1 and 2 were conducted in the W. M. Keck Geoenvironmental Laboratory at Stevens Institute of Technology, Hoboken, New Jersey. The Maryland State Highway Administration (Hanover, Maryland) provided the testing space and scales for the laboratory ND calibration. All the TS data (Table 6) were generated in Schnabel Engineering's Baltimore Soils Laboratory. Any opinions, findings, and conclusions or recommendations expressed in this material are those of the author(s) and do not necessarily reflect the views of the project sponsors. NR 43 TC 6 Z9 7 U1 0 U2 17 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 1090-0241 J9 J GEOTECH GEOENVIRON JI J. Geotech. Geoenviron. Eng. PD AUG PY 2012 VL 138 IS 8 BP 981 EP 991 DI 10.1061/(ASCE)GT.1943-5606.0000658 PG 11 WC Engineering, Geological; Geosciences, Multidisciplinary SC Engineering; Geology GA 059KI UT WOS:000312703600010 ER PT J AU Kim, HJ Naumann, CB Cornell, MC AF Kim, Hajin J. Naumann, Charles B. Cornell, Michael C. TI Hardware-in-the-loop projector system for light detection and ranging sensor testing SO OPTICAL ENGINEERING LA English DT Article DE hardware-in-the-loop; light detection and ranging; seeker; simulation; projection AB Efforts in developing a synthetic environment for testing light detection and ranging (LADAR) sensors in a hardware-in-the-loop simulation are continuing at the Aviation and Missile Research, Engineering, and Development Center of the U. S. Army Research, Engineering and Development Command (RDECOM). Current activities have concentrated on evaluating the optical projection techniques for the LADAR synthetic environment. Schemes for generating the optical signals representing the individual pixels of the projection are of particular interest. Several approaches have been investigated and tested with emphasis on operating wavelength, intensity dynamic range and uniformity, and flexibility in pixel waveform generation. This paper will discuss some of the results from these current efforts at RDECOM's System Simulation and Development Directorate's Electro Optical Technology Development Laboratory. (c) 2012 Society of Photo-Optical Instrumentation Engineers (SPIE). [DOI: 10.1117/1.OE.51.8.083609] C1 [Kim, Hajin J.] USA, Aviat & Missile Command, Aviat & Missile RDEC, AMSAM RD SS HW, Redstone Arsenal, AL 35898 USA. [Naumann, Charles B.; Cornell, Michael C.] Opt Sci Corp, Huntsville, AL 35808 USA. RP Kim, HJ (reprint author), USA, Aviat & Missile Command, Aviat & Missile RDEC, AMSAM RD SS HW, Bldg 5400, Redstone Arsenal, AL 35898 USA. EM hajin.j.kim@us.army.mil NR 4 TC 3 Z9 3 U1 1 U2 5 PU SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98225 USA SN 0091-3286 J9 OPT ENG JI Opt. Eng. PD AUG PY 2012 VL 51 IS 8 AR 083609 DI 10.1117/1.OE.51.8.083609 PG 15 WC Optics SC Optics GA 021VH UT WOS:000309913000033 ER PT J AU Pinsker, JE Crudo, DF AF Pinsker, Jordan E. Crudo, David F. TI Ganglioneuroblastoma in a young child with Turner syndrome SO JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM LA English DT Article DE abdominal mass; ganglioneuroblastoma; neuroblastoma; Turner syndrome ID GROWTH-HORMONE; NEUROBLASTOMA; TUMORS AB X chromosome aneuploidy has been identified as a potential risk factor for the development of neuroblastic tumors. We report a case of a 4-year-old girl with a 45, X karyotype incidentally discovered to have a large ganglioneuroblastoma on initial screening ultrasound. The incidence of these tumors in girls with Turner syndrome as well as their possible relationship to recombinant human growth hormone treatment is discussed. C1 [Pinsker, Jordan E.] Tripler Army Med Ctr, Div Pediat Endocrinol, Dept Pediat, Mail Code MCHK PE, Honolulu, HI 96859 USA. [Crudo, David F.] Wake Forest Univ, Bowman Gray Sch Med, Dept Pediat, Winston Salem, NC 27103 USA. RP Pinsker, JE (reprint author), Tripler Army Med Ctr, Div Pediat Endocrinol, Dept Pediat, Mail Code MCHK PE, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM jordan.pinsker@us.army.mil OI Pinsker, Jordan/0000-0003-4080-9034 NR 10 TC 0 Z9 0 U1 0 U2 1 PU WALTER DE GRUYTER GMBH PI BERLIN PA GENTHINER STRASSE 13, D-10785 BERLIN, GERMANY SN 0334-018X J9 J PEDIATR ENDOCR MET JI J. Pediatr. Endocrinol. Metab. PD AUG PY 2012 VL 25 IS 7-8 BP 799 EP 800 DI 10.1515/jpem-2012-0102 PG 2 WC Endocrinology & Metabolism; Pediatrics SC Endocrinology & Metabolism; Pediatrics GA 019RB UT WOS:000309755900033 PM 23155714 ER PT J AU Miller, RS Li, QG Cantilena, LR Leary, KJ Saviolakis, GA Melendez, V Smith, B Weina, PJ AF Miller, Robert Scott Li, Qigui Cantilena, Louis R. Leary, Kevin J. Saviolakis, George A. Melendez, Victor Smith, Bryan Weina, Peter J. TI Pharmacokinetic profiles of artesunate following multiple intravenous doses of 2, 4, and 8 mg/kg in healthy volunteers: Phase 1b study SO MALARIA JOURNAL LA English DT Article DE Artesunate injection; Severe malaria; Pharmacokinetics; Healthy volunteers; Tolerability; Multiple doses ID SEVERE FALCIPARUM-MALARIA; PLASMODIUM-FALCIPARUM; RANDOMIZED-TRIAL; AFRICAN CHILDREN; QUININE; DIHYDROARTEMISININ; NEUROTOXICITY; ARTEETHER; EFFICACY AB Background: Severe malaria results in over a million deaths every year, most of them in children aged less than five years and living in sub-Saharan Africa. Injectable artesunate (AS) was recommended as initial treatment for severe malaria by WHO in 2006. The Walter Reed Army Institute of Research (WRAIR) has been developing a novel good manufacturing practice (GMP) injection of AS, which was approved by the US FDA for investigational drug use and distribution by the CDC. Methods: Tolerability and pharmacokinetics of current GMP intravenous AS, as an anti-malarial agent, were evaluated after ascending multiple doses of 2, 4, and 8 mg/kg daily for three days with 2-minute infusion in 24 healthy subjects (divided into three groups) in the Phase 1 clinical trial study. Results: Results showed that there were no dose-dependent increases in any adverse events. Drug concentrations showed no accumulation and no decline of the drug during the three days of treatment. After intravenous injection, parent drug rapidly declined and was converted to dihydroartemisinin (DHA) with overall mean elimination half-lives ranging 0.15-0.23 hr for AS and 1.23-1.63 hr for DHA, but the peak concentration (C-max) of AS was much higher than that of DHA with a range of 3.08-3.78-folds. In addition, the AUC and C-max values of AS and DHA were increased proportionally to the AS climbing multiple doses. Discussion: The safety of injectable AS, even at the highest dose of 8 mg/kg increases the probability of therapeutic success of the drug even in patients with large variability of parasitaemia. C1 [Li, Qigui; Melendez, Victor; Weina, Peter J.] Walter Reed Army Inst Res, Dept Drug Discovery, Div Expt Therapeut, Silver Spring, MD 20910 USA. [Cantilena, Louis R.; Saviolakis, George A.] USUHS, Bethesda, MD USA. [Miller, Robert Scott; Leary, Kevin J.; Smith, Bryan] US Army Med Mat Dev Act, Ft Detrick, MD USA. RP Li, QG (reprint author), Walter Reed Army Inst Res, Dept Drug Discovery, Div Expt Therapeut, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM qigui.li@us.army.mil RI Weina, Peter/A-2120-2011 FU United States Army Research and Materiel Command FX This study was supported by the United States Army Research and Materiel Command. The opinions or assertions contained herein are the private views of the author and are not to be construed as official, or as reflecting true views of the Department of the Army or the Department of Defense. NR 32 TC 15 Z9 15 U1 2 U2 12 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1475-2875 J9 MALARIA J JI Malar. J. PD AUG 1 PY 2012 VL 11 AR 255 DI 10.1186/1475-2875-11-255 PG 10 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA 019LZ UT WOS:000309742500001 PM 22853818 ER PT J AU Walsh, MR Walsh, ME Ampleman, G Thiboutot, S Brochu, S Jenkins, TF AF Walsh, Michael R. Walsh, Marianne E. Ampleman, Guy Thiboutot, Sonia Brochu, Sylvie Jenkins, Thomas F. TI Munitions Propellants Residue Deposition Rates On Military Training Ranges SO PROPELLANTS EXPLOSIVES PYROTECHNICS LA English DT Article DE Propellants; Residues; Deposition rates; Live-fire; Military ID SALT-MARSH; LIVE-FIRE; DETONATIONS AB Training with live munitions is an integral component of preparing the modern military for warfare. Energetic compounds, such as propellants and explosives, are consumed during the use of these munitions. These compounds are never fully consumed, however, and the deposition and accumulation of energetic residue on training ranges is the result. This paper summarizes 10 years of research into propellant deposition rates for common military munitions used in the USA and Canada. Research indicates that the firing of howitzers and tanks leave very little residue, the firing of mortars can result in moderate deposition of propellant residue, small-arms firing positions have the potential for significant residue accumulation, and training with shoulder-fired rockets and 40 mm machine guns can result in dangerous quantities of unburned propellants. Residue rates vary widely for the weapon systems tested, from 10-6?% for large rocket systems to over 70?% for shoulder-fired rockets. C1 [Walsh, Michael R.; Walsh, Marianne E.; Jenkins, Thomas F.] USA, Corps Engineers, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. [Ampleman, Guy; Thiboutot, Sonia; Brochu, Sylvie] DRDC Valcartier, Quebec City, PQ G3J 1X5, Canada. RP Walsh, MR (reprint author), USA, Corps Engineers, Cold Reg Res & Engn Lab, 72 Lyme Rd, Hanover, NH 03755 USA. EM Michael.Walsh@usace.army.mil NR 43 TC 7 Z9 7 U1 3 U2 10 PU WILEY-V C H VERLAG GMBH PI WEINHEIM PA BOSCHSTRASSE 12, D-69469 WEINHEIM, GERMANY SN 0721-3115 J9 PROPELL EXPLOS PYROT JI Propellants Explos. Pyrotech. PD AUG PY 2012 VL 37 IS 4 BP 393 EP 406 DI 10.1002/prep.201100105 PG 14 WC Chemistry, Applied; Engineering, Chemical SC Chemistry; Engineering GA 984WJ UT WOS:000307223200003 ER PT J AU Bermudez, LE Inderlied, CB Kolonoski, P Chee, CB Aralar, P Petrofsky, M Parman, T Green, CE Lewin, AH Ellis, WY Young, LS AF Bermudez, Luiz E. Inderlied, Clark B. Kolonoski, Peter Chee, Christopher B. Aralar, Priscilla Petrofsky, Mary Parman, Toufan Green, Carol E. Lewin, Anita H. Ellis, William Y. Young, Lowell S. TI Identification of (+)-Erythro-Mefloquine as an Active Enantiomer with Greater Efficacy than Mefloquine against Mycobacterium avium Infection in Mice SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY LA English DT Article ID IN-VITRO; COMPLEX; ETHAMBUTOL; MOXIFLOXACIN; RECEPTOR; DISEASE; VIVO AB Infection caused by Mycobacterium avium is common in AIDS patients who do not receive treatment with highly active antiretroviral therapy (HAART) or who develop resistance to anti-HIV therapy. Mefloquine, a racemic mixture used for malaria prophylaxis and treatment, is bactericidal against M. avium in mice. MICs of (+)-erythro-, (-)-erythro-, (+)-threo-, and (-)-threo-mefloquine were 32 mu g/ml, 32 mu g/ml, 64 mu g/ml, and 64 mu g/ml, respectively. The postantibiotic effect for (+)-erythro-mefloquine was 36 h (MIC) and 41 h for a concentration of 4 x MIC. The mefloquine postantibiotic effect was 25 h (MIC and 4X MIC). After baseline infection was established (7 days), the (+)- and (-)-isomers of the diastereomeric threo- and erythro-alpha-(2piperidyl)-2,8-bis(trifluoromethyl)-4-quinolinemethanol were individually used to orally treat C57BL/6 bg(+)/bg(+) beige mice that were infected intravenously with M. avium. Mice were also treated with commercial mefloquine and diluent as controls. After 4 weeks of treatment, the mice were harvested, and the number of bacteria in spleen and liver was determined. Mice receiving (+)or (-)-threo-mefloquine or (-)-erythro-mefloquine had numbers of bacterial load in tissues similar to those of untreated control mice at 4 weeks. Commercial mefloquine had a bactericidal effect. However, mice given the (+)-erythro-enantiomer for 4 weeks had a significantly greater reduction of bacterial load than those given mefloquine. Thus, (+)-erythro-mefloquine is the active enantiomer of mefloquine against M. avium and perhaps other mycobacteria. C1 [Bermudez, Luiz E.; Kolonoski, Peter; Chee, Christopher B.; Petrofsky, Mary; Young, Lowell S.] Kuzell Inst Arthrit & Infect Dis, San Francisco, CA USA. [Inderlied, Clark B.; Aralar, Priscilla] Childrens Hosp Los Angeles, Los Angeles, CA 90027 USA. [Ellis, William Y.] Walter Reed Army Med Ctr, Walter Reed Army Inst Res, Washington, DC 20307 USA. [Bermudez, Luiz E.] Oregon State Univ, Coll Vet Med, Dept Biomed Sci, Corvallis, OR 97331 USA. [Lewin, Anita H.] Res Triangle Inst, Res Triangle Pk, NC 27709 USA. [Parman, Toufan; Green, Carol E.] SRI Int, Menlo Pk, CA 94025 USA. RP Bermudez, LE (reprint author), Kuzell Inst Arthrit & Infect Dis, San Francisco, CA USA. EM luiz.bermudez@oregonstate.edu FU National Institute of Allergy and Infectious Diseases [N02-AI-75322, NO1-AI-05417] FX This work was supported by contract numbers N02-AI-75322 and NO1-AI-05417 of the National Institute of Allergy and Infectious Diseases. NR 19 TC 3 Z9 3 U1 0 U2 5 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0066-4804 J9 ANTIMICROB AGENTS CH JI Antimicrob. Agents Chemother. PD AUG PY 2012 VL 56 IS 8 BP 4202 EP 4206 DI 10.1128/AAC.00320-12 PG 5 WC Microbiology; Pharmacology & Pharmacy SC Microbiology; Pharmacology & Pharmacy GA 979NI UT WOS:000306826300022 PM 22615290 ER PT J AU Kositanont, U Prasajak, P Trakulsomboon, S Sangjun, N Phulsuksombati, D AF Kositanont, Uraiwan Prasajak, Patcharee Trakulsomboon, Suwanna Sangjun, Noppadol Phulsuksombati, Duangpom TI Fingerprints by pulsed-field gel electrophoresis of leptospires isolated from field rats and comparison with reference Leptospira serovars SO ASIAN BIOMEDICINE LA English DT Article DE Leptospira; leptospiral serovar; molecular typing; PFGE; pulsed-field gel electrophoresis ID POLYMERASE-CHAIN-REACTION; INTERROGANS; DIFFERENTIATION; IDENTIFICATION; DNA; PCR; POLYMORPHISMS; COPENHAGENI; SEROGROUP; POMONA AB Background: More than 260 leptospiral serovars by serology have been recorded. New genotypic methods have classified Leptospira into 20 species. Serovar identification is essential for epidemiological study of this disease. Objective: We identified fingerprints from reference serovar strains of Leptospira spp. and representative serovars from field rat isolates by pulsed-field gel electrophoresis (PFGE). Methods: Extract genomic DNA from 28 reference serovars of Leptospira spp. and 13 leptospiral isolates from field rats, selected as representative serovars Pyrogenes, Bataviae, Autumnalis, and Australis, using PFGE following NotI restriction digest. Results: PFGE with NotI restriction enzyme successfully differentiated 28 reference serovars into 27 fingerprint patterns, with the exception of serovars Copenhageni and Icterohaemorrhagiae. The discriminatory power of these reference strains was 0.99. Isolates that yielded patterns identical to their corresponding serovars were serovars Pyrogenes strain Salinem and Bataviae. Patterns for isolates of serovars Autumnalis and Australis were different from reference serovar Autumnalis strain Akiyami A and serovar Australis strain Ballico used in this study. Conclusion: PFGE can be useful for identifying serovars of leptospiral isolates from reservoirs and for identifying new serovars of Leptospira for epidemiological study. C1 [Kositanont, Uraiwan; Prasajak, Patcharee] Mahidol Univ, Fac Med, Siriraj Hosp, Dept Microbiol, Bangkok 10700, Thailand. [Sangjun, Noppadol; Phulsuksombati, Duangpom] Armed Forces Res Inst Med Sci, Dept Vet Med, Bangkok 10400, Thailand. [Trakulsomboon, Suwanna] Mahidol Univ, Fac Med, Siriraj Hosp, Dept Med, Bangkok 10700, Thailand. RP Kositanont, U (reprint author), Mahidol Univ, Fac Med, Siriraj Hosp, Dept Microbiol, Bangkok 10700, Thailand. EM gruks@mahidol.ac.th FU Faculty of Graduate Studies; Siriraj Graduate Thesis Scholarship; Chalermphrakiat Grant from the Faculty of Medicine Siriraj Hospital, Mahidol University, Thailand FX This work was partly supported by a Thesis Grant, from the Faculty of Graduate Studies, the Siriraj Graduate Thesis Scholarship, and the Chalermphrakiat Grant from the Faculty of Medicine Siriraj Hospital, Mahidol University, Thailand. NR 21 TC 0 Z9 0 U1 0 U2 0 PU CHULALONGKORN UNIV, FAC MED PI BANGKOK PA CHULALONGKORN UNIV, FAC MED, 1873, RAMA 4, BANGKOK, 10330, THAILAND SN 1905-7415 J9 ASIAN BIOMED JI Asian Biomed. PD AUG PY 2012 VL 6 IS 4 BP 557 EP 564 DI 10.5372/1905-7415.0604.090 PG 8 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA 014NP UT WOS:000309382900008 ER PT J AU Dai, TH Gupta, A Murray, CK Vrahas, MS Tegos, GP Hamblin, MR AF Dai, Tianhong Gupta, Asheesh Murray, Clinton K. Vrahas, Mark S. Tegos, George P. Hamblin, Michael R. TI Blue light for infectious diseases: Propionibacterium acnes, Helicobacter pylori, and beyond? SO DRUG RESISTANCE UPDATES LA English DT Review DE Blue light; Infectious disease; Drug resistance; Intracellular porphyrins; Reactive oxygen species; Wound healing; Microbial signaling ID NARROW-SPECTRUM LIGHT; ANTIMICROBIAL PHOTODYNAMIC THERAPY; STAPHYLOCOCCUS-AUREUS INFECTION; BIPHASIC DOSE-RESPONSE; MRSA IN-VITRO; VISIBLE-LIGHT; HIGH-INTENSITY; PORPHYROMONAS-GINGIVALIS; ENVIRONMENTAL DECONTAMINATION; FUSOBACTERIUM-NUCLEATUM AB Blue light, particularly in the wavelength range of 405-470 nm, has attracted increasing attention due to its intrinsic antimicrobial effect without the addition of exogenous photosensitizers. In addition, it is commonly accepted that blue light is much less detrimental to mammalian cells than ultraviolet irradiation, which is another light-based antimicrobial approach being investigated. In this review, we discussed the blue light sensing systems in microbial cells, antimicrobial efficacy of blue light, the mechanism of antimicrobial effect of blue light, the effects of blue light on mammalian cells, and the effects of blue light on wound healing. It has been reported that blue light can regulate multi-cellular behavior involving cell-to-cell communication via blue light receptors in bacteria, and inhibit biofilm formation and subsequently potentiate light inactivation. At higher radiant exposures, blue light exhibits a broad-spectrum antimicrobial effect against both Gram-positive and Gram-negative bacteria. Blue light therapy is a clinically accepted approach for Propionibacterium acnes infections. Clinical trials have also been conducted to investigate the use of blue light for Helicobacter pylori stomach infections and have shown promising results. Studies on blue light inactivation of important wound pathogenic bacteria, including Staphylococcus aureus and Pseudomonas aeruginosa have also been reported. The mechanism of blue light inactivation of P. acnes, H. pylori, and some oral bacteria is proved to be the photo-excitation of intracellular porphyrins and the subsequent production of cytotoxic reactive oxygen species. Although it may be the case that the mechanism of blue light inactivation of wound pathogens (e.g., S. aureus, P. aeruginosa) is the same as that of P. acnes, this hypothesis has not been rigorously tested. Limited and discordant results have been reported regarding the effects of blue light on mammalian cells and wound healing. Under certain wavelengths and radiant exposures, blue light may cause cell dysfunction by the photo-excitation of blue light sensitizing chromophores, including flavins and cytochromes, within mitochondria or/and peroxisomes. Further studies should be performed to optimize the optical parameters (e.g., wavelength, radiant exposure) to ensure effective and safe blue light therapies for infectious disease. In addition, studies are also needed to verify the lack of development of microbial resistance to blue light. (C) 2012 Elsevier Ltd. All rights reserved. C1 [Dai, Tianhong; Gupta, Asheesh; Tegos, George P.; Hamblin, Michael R.] Massachusetts Gen Hosp, Wellman Ctr Photomed, Boston, MA 02114 USA. [Dai, Tianhong; Gupta, Asheesh; Tegos, George P.; Hamblin, Michael R.] Harvard Univ, Sch Med, Dept Dermatol, Boston, MA 02115 USA. [Gupta, Asheesh] Def Inst Physiol & Allied Sci, Delhi 110054, India. [Murray, Clinton K.] Brooke Army Med Ctr, Infect Dis Serv, Ft Sam Houston, TX 78234 USA. [Vrahas, Mark S.] Massachusetts Gen Hosp, Dept Orthopaed Surg, Boston, MA 02114 USA. [Tegos, George P.] Univ New Mexico, Sch Med, Dept Pathol, Albuquerque, NM 87131 USA. [Hamblin, Michael R.] MIT, Harvard Mit Div Hlth Sci & Technol, Cambridge, MA 02139 USA. RP Hamblin, MR (reprint author), Massachusetts Gen Hosp, Wellman Ctr Photomed, BAR 414,40 Blossom St, Boston, MA 02114 USA. EM hamblin@helix.mgh.harvard.edu OI Hamblin, Michael/0000-0001-6431-4605 FU NIAID NIH HHS [R01 AI050875] NR 79 TC 58 Z9 65 U1 4 U2 42 PU CHURCHILL LIVINGSTONE PI EDINBURGH PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE, LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND SN 1368-7646 J9 DRUG RESIST UPDATE JI Drug Resist. Update PD AUG PY 2012 VL 15 IS 4 BP 223 EP 236 DI 10.1016/j.drup.2012.07.001 PG 14 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA 013US UT WOS:000309332000003 PM 22846406 ER PT J AU Schlake, A Crispen, PL Cap, AP Atkinson, T Davenport, D Preston, DM AF Schlake, Anthony Crispen, Paul L. Cap, Andrew P. Atkinson, Timothy Davenport, Daniel Preston, David M. TI NMP-22, urinary cytology, and cystoscopy: a 1 year comparison study SO CANADIAN JOURNAL OF UROLOGY LA English DT Article DE urinary cytology; cystoscopy; bladder cancer; NMP-22 ID NUCLEAR-MATRIX PROTEIN-22; BLADDER-CANCER; NMP22; DIAGNOSIS; ASSAY AB Introduction: Bladder cancer diagnosis and surveillance is costly and frequent. Urinary cytology is used with cystoscopy in the diagnosis and surveillance of bladder cancer with little evidence to support this practice. Nuclear Matrix Protein-22 (NMP-22) is a marker of urothelial cell death and is elevated in the urine of patients with bladder cancer. Our study compares the performance of NMP-22, urinary cytology and office cystoscopy when utilized in a Veteran Affairs urology practice for 1 year. Materials and methods: A total of 391 consecutive office cystoscopy procedures performed over 1 year were included in the study. NMP-22 and cytology were performed on the urine specimens of patients presenting for cystoscopy. Tumor resection/bladder biopsy was performed when cystoscopy, NMP-22 or urinary cytology were abnormal. Results: Cystoscopy, NMP-22, and urinary cytology data were available in 351 encounters and 69 tumor resections were performed. Urothelial carcinoma bladder (UCB) was identified in 37 bladder specimens. NMP-22, urinary cytology and cystoscopy demonstrated sensitivity and specificity of (51%/96%), (35%/97%), and (92%/88%), respectively. NMP-22 cost $8,750 in the study group and urinary cytology cost $52,500 in the same group. Conclusions: This study demonstrates cystoscopy was the most sensitive test in the diagnosis of UCB. NMP-22 had a higher sensitivity than urinary cytology and similar specificity to cytology. Additional urinary marker testing has a limited role in the management of bladder cancer in the office setting. When adjunct testing is desired in the diagnosis and surveillance of bladder cancer, NMP-22 is a cost effective alternative to urinary cytology. C1 [Schlake, Anthony; Crispen, Paul L.; Davenport, Daniel; Preston, David M.] Univ Kentucky, Dept Surg, Lexington, KY USA. [Crispen, Paul L.; Atkinson, Timothy; Davenport, Daniel; Preston, David M.] Dept Vet Affairs Med Ctr, Lexington, KY USA. [Cap, Andrew P.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Preston, DM (reprint author), 1101 Vet Dr, Lexington, KY 40502 USA. NR 18 TC 6 Z9 7 U1 0 U2 1 PU CANADIAN J UROLOGY PI ST LAURENT PA 2330 WARD ST, STE 604, ST LAURENT, QUEBEC H4M 2V6, CANADA SN 1195-9479 J9 CAN J UROL JI Can. J. Urol. PD AUG PY 2012 VL 19 IS 4 BP 6345 EP 6350 PG 6 WC Urology & Nephrology SC Urology & Nephrology GA 010MF UT WOS:000309097800005 PM 22892257 ER PT J AU Webb, RC Howard, RS Stojadinovic, A Gaitonde, DY Wallace, MK Ahmed, J Burch, HB AF Webb, Richard C. Howard, Robin S. Stojadinovic, Alexander Gaitonde, David Y. Wallace, Mark K. Ahmed, Jehanara Burch, Henry B. TI The Utility of Serum Thyroglobulin Measurement at the Time of Remnant Ablation for Predicting Disease-Free Status in Patients with Differentiated Thyroid Cancer: A Meta-Analysis Involving 3947 Patients SO JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM LA English DT Article ID POSTSURGICAL STIMULATED THYROGLOBULIN; RECOMBINANT HUMAN THYROTROPIN; LOW-RISK PATIENTS; PROGNOSTIC VALUE; FOLLOW-UP; HORMONE WITHDRAWAL; INITIAL TREATMENT; BODY SCAN; CARCINOMA; RECURRENCE AB Context: Decisions regarding initial therapy and subsequent surveillance in patients with differentiated thyroid cancer (DTC) depend upon an accurate assessment of the risk of persistent or recurrent disease. Objective: The objective of this study was to examine the predictive value of a single measurement of serum thyroglobulin (Tg) just before radioiodine remnant ablation (preablation Tg) on subsequent disease-free status. Data Sources: Sources included MEDLINE and BIOSYS databases between January 1996 and June 2011 as well as data from the author's tertiary-care medical center. Study Selection: Included studies reported preablation Tg values and the outcome of initial therapy at surveillance testing or during the course of long-term follow-up. Data Extraction: Two investigators independently extracted data and rated study quality using the Quality Assessment of Studies of Diagnostic Accuracy included in Systematic Reviews-2 (QUADAS-2) tool. Data Synthesis: Fifteen studies involving 3947 patients with DTC were included. Seventy percent of patients had preablation Tg values lower than the threshold value being examined. The negative predictive value (NPV) of a preablation Tg below threshold was 94.2 (95% confidence interval = 92.8-95.3) for an absence of biochemical or structural evidence of disease at initial surveillance or subsequent follow-up. The summary receiver operator characteristic curve based on a bivariate mixed-effects binomial regression model showed a clustering of studies using a preablation Tg below 10 ng/ml near the summary point of optimal test sensitivity and specificity. Conclusion: Preablation Tg testing is a readily available and in expensive tool with high NPV for future disease-free status. A low preablation Tg should be considered a favorable risk factor in patients with DTC. Further study is required to determine whether a low preablation Tg may be used to select patients for whom radioiodine remnant ablation can be avoided. (J Clin Endocrinol Metab97: 2754-2763, 2012) C1 [Burch, Henry B.] Uniformed Serv Univ Hlth Sci, Dept Med, Div Endocrine, Bethesda, MD 20889 USA. [Webb, Richard C.; Stojadinovic, Alexander] Walter Reed Natl Mil Med Ctr, Biostat Div, Dept Surg, Bethesda, MD 20889 USA. [Howard, Robin S.] Walter Reed Natl Mil Med Ctr, Biostat Div, Res Programs, Bethesda, MD 20889 USA. [Burch, Henry B.] Walter Reed Natl Mil Med Ctr, Dept Med, Serv Endocrinol, Bethesda, MD 20889 USA. [Stojadinovic, Alexander] US Mil Canc Inst, Bethesda, MD 20889 USA. [Gaitonde, David Y.] Dwight D Eisenhower Army Med Ctr, Dept Med, Serv Endocrinol, Ft Gordon, GA 30905 USA. [Wallace, Mark K.] Brooke Army Med Ctr, Serv Endocrinol, Ft Sam Houston, TX 78234 USA. [Ahmed, Jehanara] SE Med Associates, Beaumont, TX 77701 USA. RP Burch, HB (reprint author), Uniformed Serv Univ Hlth Sci, Dept Med, Div Endocrine, Bethesda, MD 20889 USA. EM henry.burch@med.navy.mil NR 42 TC 48 Z9 55 U1 0 U2 9 PU ENDOCRINE SOC PI CHEVY CHASE PA 8401 CONNECTICUT AVE, SUITE 900, CHEVY CHASE, MD 20815-5817 USA SN 0021-972X J9 J CLIN ENDOCR METAB JI J. Clin. Endocrinol. Metab. PD AUG PY 2012 VL 97 IS 8 BP 2754 EP 2763 DI 10.1210/jc.2012-1533 PG 10 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA 987ZI UT WOS:000307457400060 PM 22639291 ER PT J AU Doona, CJ Feeherry, FE Ross, EW Kustin, K AF Doona, Christopher J. Feeherry, Florence E. Ross, Edward W. Kustin, Kenneth TI Inactivation Kinetics of Listeria monocytogenes by High-Pressure Processing: Pressure and Temperature Variation SO JOURNAL OF FOOD SCIENCE LA English DT Article DE enhanced quasi-chemical kinetics (EQCK) model; food safety; high-pressure processing (HPP); Listeria monocytogenes inactivation kinetics; predictive microbiology ID PREDICTING MICROBIAL INACTIVATION; HIGH HYDROSTATIC-PRESSURE; QUASI-CHEMICAL MODEL; SUPERDORMANT SPORES; DEATH; GROWTH; MICROORGANISMS; ACTIVATION; PATHOGENS; CURVES AB The enhanced quasi-chemical kinetics (EQCK) model is presented as a methodology to evaluate the nonlinear inactivation kinetics of baro-resistant Listeria monocytogenes in a surrogate protein food system by high-pressure processing (HPP) for various combinations of pressure (P= 207 to 414 MPa) and temperature (T= 20 to 50 degrees C). The EQCK model is based on ordinary differential equations derived from 6 quasi-chemical reaction steps. The EQCK model continuously fits the conventional stages of the microbial lifecycle: lag, growth, stationary phase, and death; and tailing. Depending on the conditions, the inactivation kinetics of L. monocytogenes by HPP show a lag, inactivation, and tailing. Accordingly, we developed a customized, 4-step subset version of the EQCK model sufficient to evaluate the HPP inactivation kinetics of L. monocytogenes and obtain values for the model parameters of lag (?), inactivation rate (mu), rate constants (k), and processing time (tp). This latter parameter was developed uniquely to evaluate kinetics data showing tailing. Secondary models are developed by interrelating the fitting parameters with experimental parameters, and Monte Carlo simulations are used to evaluate parameter reproducibility. This 4-step model is also compared with the empirical Weibull and Polylog models. The success of the EQCK model (as its 4-step subset) for the HPP inactivation kinetics of baro-resistant L. monocytogenes showing tailing establishes several advantages of the EQCK modeling approach for investigating nonlinear microbial inactivation kinetics, and it has implications for determining mechanisms of bacterial spore inactivation by HPP. Practical Application: Results of this study will be useful to the many segments of the food processing industry (ready-to-eat meats, fresh produce, seafood, dairy) concerned with ensuring the safety of consumers from the health hazards of Listeria monocytogenes, particularly through the use of emerging food preservation technologies such as high-pressure processing. C1 [Doona, Christopher J.; Feeherry, Florence E.; Ross, Edward W.] USA, Natick Soldier RD&E Ctr, RDNS WSC, Natick, MA 01760 USA. [Kustin, Kenneth] Brandeis Univ, Dept Chem, Waltham, MA 02254 USA. RP Doona, CJ (reprint author), USA, Natick Soldier RD&E Ctr, RDNS WSC, Kansas St, Natick, MA 01760 USA. EM christopher.j.doona.civ@mail.mil NR 30 TC 8 Z9 8 U1 2 U2 45 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0022-1147 J9 J FOOD SCI JI J. Food Sci. PD AUG PY 2012 VL 77 IS 8 BP M458 EP M465 DI 10.1111/j.1750-3841.2012.02791.x PG 8 WC Food Science & Technology SC Food Science & Technology GA 986ZI UT WOS:000307385800026 PM 22748039 ER PT J AU Jabara, B Punch, G Ching, B AF Jabara, Benjamin Punch, Greg Ching, Brian TI Neurologic Complication after Use of a Percutaneous Vascular Closure Device SO JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY LA English DT Letter C1 [Jabara, Benjamin; Punch, Greg; Ching, Brian] Tripler Army Med Ctr, Dept Radiol, Honolulu, HI 96859 USA. RP Jabara, B (reprint author), Tripler Army Med Ctr, Dept Radiol, 1 Jarrett White Rd, Honolulu, HI 96859 USA. NR 3 TC 1 Z9 1 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1051-0443 J9 J VASC INTERV RADIOL JI J. Vasc. Interv. Radiol. PD AUG PY 2012 VL 23 IS 8 BP 1099 EP 1101 DI 10.1016/j.jvir.2012.04.028 PG 3 WC Radiology, Nuclear Medicine & Medical Imaging; Peripheral Vascular Disease SC Radiology, Nuclear Medicine & Medical Imaging; Cardiovascular System & Cardiology GA 980AI UT WOS:000306865600018 PM 22840809 ER PT J AU Yu, AB Zacks, JM AF Yu, Alfred B. Zacks, Jeffrey M. TI Off with his head! The role of embodied transformations in perspective taking SO COGNITIVE PROCESSING LA English DT Meeting Abstract C1 [Yu, Alfred B.] Washington Univ, Dept Psychol, Human Res & Engn Directorate, USA,Res Lab, St Louis, MO 63130 USA. RI Zacks, Jeffrey/E-9099-2011 OI Zacks, Jeffrey/0000-0003-1171-3690 NR 0 TC 0 Z9 0 U1 0 U2 2 PU SPRINGER HEIDELBERG PI HEIDELBERG PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY SN 1612-4782 J9 COGN PROCESS JI Cogn. Process. PD AUG PY 2012 VL 13 SU 1 SI SI BP S22 EP S23 PG 2 WC Psychology, Experimental SC Psychology GA 006NA UT WOS:000308824700079 ER PT J AU Clark, PJ Thompson, AJ Zhu, QQ Vock, DM Zhu, MF Patel, K Harrison, SA Naggie, S Ge, DL Tillmann, HL Urban, TJ Shianna, K Fellay, J Goodman, Z Noviello, S Pedicone, LD Afdhal, N Sulkowski, M Albrecht, JK Goldstein, DB McHutchison, JG Muir, AJ AF Clark, Paul J. Thompson, Alexander J. Zhu, Qianqian Vock, David M. Zhu, Mingfu Patel, Keyur Harrison, Stephen A. Naggie, Susanna Ge, Dongliang Tillmann, Hans L. Urban, Thomas J. Shianna, Kevin Fellay, Jacques Goodman, Zachary Noviello, Stephanie Pedicone, Lisa D. Afdhal, Nezam Sulkowski, Mark Albrecht, Janice K. Goldstein, David B. McHutchison, John G. Muir, Andrew J. TI The Association of Genetic Variants with Hepatic Steatosis in Patients with Genotype 1 Chronic Hepatitis C Infection SO DIGESTIVE DISEASES AND SCIENCES LA English DT Article DE Polymorphism, single-nucleotide, SNP; IL28B protein, human; PNPLA3 protein, human; Adiponutrin, human; Fatty liver; Abdominal obesity metabolic syndrome ID FATTY LIVER-DISEASE; PNPLA3 I148M MUTATION; ALCOHOL INTAKE; FIBROSIS PROGRESSION; IL28B GENOTYPE; UNITED-STATES; EXPRESSION; DAMAGE; PEGINTERFERON; POLYMORPHISM AB Single-nucleotide polymorphisms (SNPs) in the IL28B and PNPLA3 gene regions have been associated with hepatic steatosis in genotype 1 (G1) chronic HCV infection but their clinical impacts remain to be determined. We sought to validate these associations and to explore their impact on treatment response to peginterferon and ribavirin therapy. A total of 972 G1 HCV-infected Caucasian patients were genotyped for the SNPs rs12979860 (IL28B) and rs2896019 (PNPLA3). Multivariable analysis tested IL28B and PNPLA3 for association with the presence of any steatosis (> 0 %); clinically significant steatosis (> 5 %); steatosis severity (grade 0-3/4); and the interacting associations of the SNPs and hepatic steatosis to sustained viral response (SVR). IL28B and PNPLA3 polymorphisms were associated with the presence of any steatosis (rs12979860, p = 1.87 x 10(-7); rs2896019, p = 7.56 x 10(-4)); clinically significant steatosis (rs12979860, p = 1.82 x 10(-3); rs2896019, p = 1.27 x 10(-4)); and steatosis severity (rs12979860, p = 2.05 x 10(-8); rs2896019, p = 2.62 x 10(-6)). Obesity, hypertriglyceridemia, hyperglycemia, liver fibrosis, and liver inflammation were all independently associated with worse steatosis. Hepatic steatosis was associated with lower SVR, and this effect was attenuated by IL28B. PNPLA3 had no independent association with SVR. IL28B and PNPLA3 are associated with hepatic steatosis prevalence and severity in Caucasians with G1 HCV, suggesting differing potential genetic risk pathways to steatosis. IL28B attenuates the association between steatosis and SVR. Remediable metabolic risk factors remain important, independently of these polymorphisms, and remain key therapeutic goals to achieve better outcomes for patients with HCV-associated hepatic steatosis. C1 [Clark, Paul J.; Thompson, Alexander J.; Vock, David M.; Patel, Keyur; Naggie, Susanna; Tillmann, Hans L.; McHutchison, John G.; Muir, Andrew J.] Duke Univ, Duke Clin Res Inst, Durham, NC 27715 USA. [Clark, Paul J.] Univ New S Wales, Kirby Inst Infect & Immun Soc, Kensington, NSW 2033, Australia. [Zhu, Qianqian; Zhu, Mingfu; Ge, Dongliang; Urban, Thomas J.; Shianna, Kevin; Fellay, Jacques; Goldstein, David B.] Duke Univ, Ctr Human Genome Variat, Durham, NC USA. [Harrison, Stephen A.] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. [Goodman, Zachary] Armed Forces Inst Pathol, Washington, DC 20306 USA. [Noviello, Stephanie; Pedicone, Lisa D.; Albrecht, Janice K.] Merck & Co Inc, Whitehouse Stn, NJ USA. [Afdhal, Nezam] Beth Israel Deaconess Med Ctr, Boston, MA 02215 USA. [Sulkowski, Mark] Johns Hopkins Univ, Sch Med, Baltimore, MD USA. RP Clark, PJ (reprint author), Duke Univ, Duke Clin Res Inst, POB 17969, Durham, NC 27715 USA. EM drpjclark@gmail.com; muir0002@mc.duke.edu RI Zhu, Mingfu/F-3217-2011; Clark, Paul/A-1480-2012; Fellay, Jacques/A-6681-2009; OI Zhu, Mingfu/0000-0003-0296-712X; Clark, Paul/0000-0002-1821-4969; Fellay, Jacques/0000-0002-8240-939X; Vock, David M/0000-0002-5459-9579 FU Merck and Co.; Duke Clinical Research Institute; Richard Boebel Family Fund; National Health and Medical Research Council of Australia [APP1017139]; Gastroenterological Society of Australia; Royal Australian College of Physicians; Kirby Institute for Infection and Immunity in Society, University of New South Wales, Australia; AASLD/LIFER; Merck; Genentech; Rottapharm FX The authors would like to thank the patients in the IDEAL trial as well as the principal investigators, study coordinators, and nurses involved. The authors thank Megan Koehler, DCRI for her statistical review. The study was funded by Schering-Plough Research Institute, Kenilworth, NJ (now Merck and Co.). Drs. Clark and Thompson received funding support from the Duke Clinical Research Institute, the Richard Boebel Family Fund, the National Health and Medical Research Council of Australia (PJC: APP1017139), the Gastroenterological Society of Australia. Dr Thompson received funding from the Royal Australian College of Physicians. Dr. Clark received funding from the National Centre in HIV Epidemiology and Clinical Research (now The Kirby Institute for Infection and Immunity in Society), University of New South Wales, Australia, and the AASLD/LIFER Clinical and Translational Research Fellowship in Liver Diseases Award.; The authors disclose the following: Drs. Thompson, Harrison, Sulkowski, Afdhal, McHutchison and Muir report having received research and grant support from Schering-Plough (now Merck); Drs Afdhal, Harrison, McHutchison, Goldstein and Muir have received consulting fees or acted in an advisory capacity for Schering-Plough or Merck. Dr Harrison has received grant and research support from Genentech, Merck, and Rottapharm, worked in an advisory capacity for Three Rivers Pharmaceuticals and Amylin and for speaker's bureau for Bristol Myers Squibb and Merck. Drs Albrecht and Pedicone are employees of Schering-Plough (now Merck & Co.) and are stockholders in this entity. Dr McHutchison is now employed by Gilead Sciences. Dr Noviello is a former employee of Schering-Plough and is now a consultant to Merck & Co. Drs. Thompson, Ge, Urban, McHutchison and Goldstein are co-inventors of a patent application based on the IL28B finding. NR 36 TC 19 Z9 20 U1 1 U2 6 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0163-2116 J9 DIGEST DIS SCI JI Dig. Dis. Sci. PD AUG PY 2012 VL 57 IS 8 BP 2213 EP 2221 DI 10.1007/s10620-012-2171-y PG 9 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 980YM UT WOS:000306930100033 PM 22543885 ER PT J AU Cvengros, RM Valente, D Nykaza, ET Vipperman, JS AF Cvengros, Robert M. Valente, Dan Nykaza, Edward T. Vipperman, Jeffrey S. TI Blast noise classification with common sound level meter metrics SO JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA LA English DT Article ID SUPPORT VECTOR MACHINES AB A common set of signal features measurable by a basic sound level meter are analyzed, and the quality of information carried in subsets of these features are examined for their ability to discriminate military blast and non-blast sounds. The analysis is based on over 120 000 human classified signals compiled from seven different datasets. The study implements linear and Gaussian radial basis function (RBF) support vector machines (SVM) to classify blast sounds. Using the orthogonal centroid dimension reduction technique, intuition is developed about the distribution of blast and non-blast feature vectors in high dimensional space. Recursive feature elimination (SVM-RFE) is then used to eliminate features containing redundant information and rank features according to their ability to separate blasts from non-blasts. Finally, the accuracy of the linear and RBF SVM classifiers is listed for each of the experiments in the dataset, and the weights are given for the linear SVM classifier. (C) 2012 Acoustical Society of America. [http://dx.doi.org/10.1121/1.4730921] C1 [Cvengros, Robert M.; Valente, Dan; Nykaza, Edward T.] USA, Corps Engineers, Engineer Res & Dev Ctr, Champaign, IL 61820 USA. [Vipperman, Jeffrey S.] Univ Pittsburgh, Dept Mech Engn & Mat Sci, Pittsburgh, PA 15261 USA. RP Valente, D (reprint author), USA, Corps Engineers, Engineer Res & Dev Ctr, Champaign, IL 61820 USA. EM daniel.p.valente@usace.army.mil FU Strategic Environmental Research and Development Program (SERDP) FX The authors would like to thank Chris Shelton, Tom Noble, Jesse Barr, Kaylee Burow, and Lauren Ronsse for their work in classifying the signals from the various datasets. We would also like to thank a reviewer of a previous version of this manuscript for their comments on human error in classification. This work was funded by the Strategic Environmental Research and Development Program (SERDP). Any opinions, findings, and conclusions or recommendations expressed in this material are those of the authors, do not necessarily reflect the views of the funding agency, and are not to be construed as an official Department of the Army position unless so designated by other authorized documents. Distribution Statement - A (Approved for public release; distribution unlimited). NR 13 TC 0 Z9 0 U1 1 U2 6 PU ACOUSTICAL SOC AMER AMER INST PHYSICS PI MELVILLE PA STE 1 NO 1, 2 HUNTINGTON QUADRANGLE, MELVILLE, NY 11747-4502 USA SN 0001-4966 J9 J ACOUST SOC AM JI J. Acoust. Soc. Am. PD AUG PY 2012 VL 132 IS 2 BP 822 EP 831 DI 10.1121/1.4730921 PG 10 WC Acoustics; Audiology & Speech-Language Pathology SC Acoustics; Audiology & Speech-Language Pathology GA 010FD UT WOS:000309079200042 PM 22894205 ER PT J AU Owens, BD Dickens, JF Kilcoyne, KG Rue, JPH AF Owens, Brett D. Dickens, Jonathan F. Kilcoyne, Kelly G. Rue, John-Paul H. TI Management of Mid-season Traumatic Anterior Shoulder Instability in Athletes SO JOURNAL OF THE AMERICAN ACADEMY OF ORTHOPAEDIC SURGEONS LA English DT Review ID ARTHROSCOPIC BANKART REPAIR; INFERIOR GLENOHUMERAL LIGAMENT; RANDOMIZED CONTROLLED-TRIAL; FOLLOW-UP; NONOPERATIVE TREATMENT; EXTERNAL ROTATION; CLINICAL-TRIAL; DISLOCATION; STABILIZATION; IMMOBILIZATION AB Shoulder dislocation and subluxation injuries are common in young athletes and most frequently occur during the competitive season. Controversy exists regarding optimal treatment of an athlete with an in-season shoulder dislocation, and limited data are available to guide treatment. Rehabilitation may facilitate return to sport within 3 weeks, but return is complicated by a moderate risk of recurrence. Bracing may reduce the risk of recurrence, but it restricts motion and may not be tolerated in patients who must complete certain sport-specific tasks such as throwing. Surgical management of shoulder dislocation or subluxation with arthroscopic or open Bankart repair reduces the rate of recurrence; however, the athlete is unable to participate in sport for the remainder of the competitive season. When selecting a management option, the clinician must consider the natural history of shoulder instability, pathologic changes noted on examination and imaging, sport- and position-specific demands, duration of treatment, and the athlete's motivation. C1 [Owens, Brett D.] Keller Army Community Hosp, West Point, NY USA. [Dickens, Jonathan F.; Kilcoyne, Kelly G.] Walter Reed Natl Mil Med Ctr, Dept Orthopaed & Rehabil, Washington, DC USA. [Rue, John-Paul H.] USN Acad, Dept Orthopaed & Sports Med, Annapolis, MD USA. RP Owens, BD (reprint author), Keller Army Community Hosp, West Point, NY USA. NR 53 TC 17 Z9 17 U1 0 U2 17 PU AMER ACAD ORTHOPAEDIC SURGEONS PI ROSEMENT PA 6300 N RIVER ROAD, ROSEMENT, IL 60018-4262 USA SN 1067-151X J9 J AM ACAD ORTHOP SUR JI J. Am. Acad. Orthop. Surg. PD AUG PY 2012 VL 20 IS 8 BP 518 EP 526 DI 10.5435/JAAOS-20-08-518 PG 9 WC Orthopedics; Surgery SC Orthopedics; Surgery GA 984NY UT WOS:000307198900005 PM 22855854 ER PT J AU Kraft, RH Mckee, PJ Dagro, AM Grafton, ST AF Kraft, Reuben H. Mckee, Phillip Justin Dagro, Amy M. Grafton, Scott T. TI Combining the Finite Element Method with Structural Connectome-based Analysis for Modeling Neurotrauma: Connectome Neurotrauma Mechanics SO PLOS COMPUTATIONAL BIOLOGY LA English DT Article ID TRAUMATIC BRAIN-INJURY; GRAPH-THEORETICAL ANALYSIS; WHITE-MATTER CONNECTIVITY; CENTRAL-NERVOUS-SYSTEM; SMALL-WORLD NETWORKS; CORTICAL NETWORKS; DYNAMIC-RESPONSE; HEAD; TISSUE; GENERATION AB This article presents the integration of brain injury biomechanics and graph theoretical analysis of neuronal connections, or connectomics, to form a neurocomputational model that captures spatiotemporal characteristics of trauma. We relate localized mechanical brain damage predicted from biofidelic finite element simulations of the human head subjected to impact with degradation in the structural connectome for a single individual. The finite element model incorporates various length scales into the full head simulations by including anisotropic constitutive laws informed by diffusion tensor imaging. Coupling between the finite element analysis and network-based tools is established through experimentally-based cellular injury thresholds for white matter regions. Once edges are degraded, graph theoretical measures are computed on the "damaged" network. For a frontal impact, the simulations predict that the temporal and occipital regions undergo the most axonal strain and strain rate at short times (less than 24 hrs), which leads to cellular death initiation, which results in damage that shows dependence on angle of impact and underlying microstructure of brain tissue. The monotonic cellular death relationships predict a spatiotemporal change of structural damage. Interestingly, at 96 hrs post-impact, computations predict no network nodes were completely disconnected from the network, despite significant damage to network edges. At early times (t<24 hrs) network measures of global and local efficiency were degraded little; however, as time increased to 96 hrs the network properties were significantly reduced. In the future, this computational framework could help inform functional networks from physics-based structural brain biomechanics to obtain not only a biomechanics-based understanding of injury, but also neurophysiological insight. C1 [Kraft, Reuben H.; Dagro, Amy M.] USA, Soldier Protect Sci Branch, Protect Div, Res Lab, Aberdeen Proving Ground, MD USA. [Mckee, Phillip Justin] Dynamic Sci Inc, Aberdeen Proving Ground, MD USA. [Grafton, Scott T.] Univ Calif Santa Barbara, Dept Psychol, Santa Barbara, CA 93106 USA. RP Kraft, RH (reprint author), USA, Soldier Protect Sci Branch, Protect Div, Res Lab, Aberdeen Proving Ground, MD USA. EM reuben.kraft@gmail.com FU U.S. Department of Defense, Department of the Army FX This work was funded by the U.S. Department of Defense, Department of the Army. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 66 TC 19 Z9 20 U1 0 U2 13 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1553-7358 J9 PLOS COMPUT BIOL JI PLoS Comput. Biol. PD AUG PY 2012 VL 8 IS 8 AR e1002619 DI 10.1371/journal.pcbi.1002619 PG 15 WC Biochemical Research Methods; Mathematical & Computational Biology SC Biochemistry & Molecular Biology; Mathematical & Computational Biology GA 002SA UT WOS:000308553500008 PM 22915997 ER PT J AU Ripoll, DR Khavrutskii, IV Chaudhury, S Liu, J Kuschner, RA Wallqvist, A Reifman, J AF Ripoll, Daniel R. Khavrutskii, Ilja V. Chaudhury, Sidhartha Liu, Jin Kuschner, Robert A. Wallqvist, Anders Reifman, Jaques TI Quantitative Predictions of Binding Free Energy Changes in Drug-Resistant Influenza Neuraminidase SO PLOS COMPUTATIONAL BIOLOGY LA English DT Article ID MOLECULAR-DYNAMICS; CRYSTAL-STRUCTURES; CONTINUUM SOLVENT; LIGAND-BINDING; VIRUS; OSELTAMIVIR; INHIBITORS; DESIGN; FLEXIBILITY; SENSITIVITY AB Quantitatively predicting changes in drug sensitivity associated with residue mutations is a major challenge in structural biology. By expanding the limits of free energy calculations, we successfully identified mutations in influenza neuraminidase (NA) that confer drug resistance to two antiviral drugs, zanamivir and oseltamivir. We augmented molecular dynamics (MD) with Hamiltonian Replica Exchange and calculated binding free energy changes for H274Y, N294S, and Y252H mutants. Based on experimental data, our calculations achieved high accuracy and precision compared with results from established computational methods. Analysis of 15 mu s of aggregated MD trajectories provided insights into the molecular mechanisms underlying drug resistance that are at odds with current interpretations of the crystallographic data. Contrary to the notion that resistance is caused by mutant-induced changes in hydrophobicity of the binding pocket, our simulations showed that drug resistance mutations in NA led to subtle rearrangements in the protein structure and its dynamics that together alter the active-site electrostatic environment and modulate inhibitor binding. Importantly, different mutations confer resistance through different conformational changes, suggesting that a generalized mechanism for NA drug resistance is unlikely. C1 [Ripoll, Daniel R.; Khavrutskii, Ilja V.; Chaudhury, Sidhartha; Liu, Jin; Wallqvist, Anders; Reifman, Jaques] USA, Dept Def Biotechnol, High Performance Comp Software Applicat Inst, Telemed & Adv Technol Res Ctr,Med Res & Mat Comma, Frederick, MD USA. [Kuschner, Robert A.] Walter Reed Army Inst Res, Emerging Infect Dis Res Unit, Silver Spring, MD USA. RP Ripoll, DR (reprint author), USA, Dept Def Biotechnol, High Performance Comp Software Applicat Inst, Telemed & Adv Technol Res Ctr,Med Res & Mat Comma, Frederick, MD USA. EM jaques.reifman@us.army.mil OI wallqvist, anders/0000-0002-9775-7469 FU Military Infectious Diseases Research Program of the United States (US) Army Medical Research and Materiel Command, Fort Detrick, Maryland; US Department of Defense (DoD) High-Performance Computing Modernization Program FX Support for this research was provided by the Military Infectious Diseases Research Program of the United States (US) Army Medical Research and Materiel Command, Fort Detrick, Maryland, and the US Department of Defense (DoD) High-Performance Computing Modernization Program. The opinions and assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the US Army or the US DoD. This paper has been approved for public release with unlimited distribution. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 41 TC 7 Z9 7 U1 0 U2 7 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1553-7358 J9 PLOS COMPUT BIOL JI PLoS Comput. Biol. PD AUG PY 2012 VL 8 IS 8 AR e1002665 DI 10.1371/journal.pcbi.1002665 PG 10 WC Biochemical Research Methods; Mathematical & Computational Biology SC Biochemistry & Molecular Biology; Mathematical & Computational Biology GA 002SA UT WOS:000308553500043 PM 22956900 ER PT J AU Zubko, E Muinonen, K Shkuratov, Y Hadamcik, E Levasseur-Regourd, AC Videen, G AF Zubko, E. Muinonen, K. Shkuratov, Y. Hadamcik, E. Levasseur-Regourd, A. -C. Videen, G. TI Evaluating the carbon depletion found by the Stardust mission in Comet 81P/Wild 2 SO ASTRONOMY & ASTROPHYSICS LA English DT Article DE comets: general; comets: individual: 81p/Wild 2; polarization ID PHASE ANGLES; HALLEY DUST; POLARIMETRY AB The low abundance of refractory carbonaceous material in samples collected by Stardust in comet 81P/Wild 2 coma was completely unexpected. If these results are universal to other comets, this necessitates a reformulation of current models of solar system formation. A polarimetric imaging analysis demonstrates that dust is not uniformly distributed within cometary coma, and that the circumnucleus halo region where the dust samples were collected must contain a low population of carbonaceous particles. Such regions are seen in other comets, suggesting that comet 81P/Wild 2 is not unusual and that the anomalous lack of carbon is not necessarily representative of the entire coma. C1 [Zubko, E.; Muinonen, K.] Univ Helsinki, Dept Phys, Helsinki 00014, Finland. [Zubko, E.; Shkuratov, Y.] Kharkov Natl Univ, Inst Astron, UA-61022 Kharkov, Ukraine. [Muinonen, K.] Finnish Geodet Inst, Masala 02431, Finland. [Hadamcik, E.] Univ Paris 06, LATMOS, F-78280 Guyancourt, France. [Levasseur-Regourd, A. -C.] Univ Paris 06, LATMOS, F-75005 Paris, France. [Videen, G.] Space Sci Inst, Boulder, CO 80301 USA. [Videen, G.] USA, Res Lab, Adelphi, MD 20783 USA. RP Zubko, E (reprint author), Univ Helsinki, Dept Phys, POB 64, Helsinki 00014, Finland. EM ezubko@rambler.ru FU Academy of Finland [127461]; NASA program for Outer Planets Research [NNX10AP93G]; French space agency (CNES); French Programme national de planetologie (PNP) FX This work was partially supported by the Academy of Finland (contract 127461), by the NASA program for Outer Planets Research (grant NNX10AP93G), by the French space agency (CNES) and by the French Programme national de planetologie (PNP). The authors are grateful to the anonymous referee for valuable comments on this paper. NR 35 TC 9 Z9 9 U1 0 U2 5 PU EDP SCIENCES S A PI LES ULIS CEDEX A PA 17, AVE DU HOGGAR, PA COURTABOEUF, BP 112, F-91944 LES ULIS CEDEX A, FRANCE SN 0004-6361 J9 ASTRON ASTROPHYS JI Astron. Astrophys. PD AUG PY 2012 VL 544 AR L8 DI 10.1051/0004-6361/201218981 PG 4 WC Astronomy & Astrophysics SC Astronomy & Astrophysics GA 999DS UT WOS:000308290100168 ER PT J AU Miao, GW Li, Y Swami, A AF Miao, Guowang Li, Ye (Geoffrey) Swami, Ananthram TI Channel-Aware Distributed Medium Access Control SO IEEE-ACM TRANSACTIONS ON NETWORKING LA English DT Article DE Channel-aware; distributed; medium access control (MAC); random access; scheduling ID CROSS-LAYER OPTIMIZATION; MULTICHANNEL RANDOM-ACCESS; OFDM WIRELESS NETWORKS; AD-HOC NETWORKS; CELLULAR NETWORKS; POWER-CONTROL; ALOHA; INTERFERENCE; INFORMATION; FAIRNESS AB In this paper, we solve a fundamental problem: how to use distributed random access to achieve the performance of centralized schedulers. We consider wireless networks with arbitrary topologies and spatial traffic distributions, where users can receive traffic from or send traffic to different users and different communication links may interfere with each other. The channels are assumed heterogeneous, and the random channel gains of different links may have different distributions. To resolve the network contention in a distributed way, each frame is divided into contention and transmission periods. The contention period is used to resolve conflicts, while the transmission period is used to send payload in collision-free scenarios. We design a multistage channel-aware Aloha scheme for the contention period to enable users with relatively better channel states to have higher probabilities of contention success while assuring fairness among all users. We show analytically that the proposed scheme completely resolves network contention and achieves throughput close to that of centralized schedulers. Furthermore, the proposed scheme is robust to any uncertainty in channel estimation. Simulation results demonstrate that it significantly improves network performance while maintaining fairness among different users. The proposed random access approach can be applied to different wireless networks, such as cellular, sensor, and mobile ad hoc networks, to improve quality of service. C1 [Miao, Guowang] Royal Inst Technol, Sch Informat & Commun Technol, S-16440 Kista, Sweden. [Li, Ye (Geoffrey)] Georgia Inst Technol, Sch Elect & Comp Engn, Atlanta, GA 30332 USA. [Swami, Ananthram] USA, CISD, Res Lab, Adelphi, MD 20783 USA. RP Miao, GW (reprint author), Royal Inst Technol, Sch Informat & Commun Technol, S-16440 Kista, Sweden. EM guowangmiao@gmail.com FU Intel Corporation; U.S. Army Research Laboratory under the Collaborative Technology Alliance Program [DAAD19-01-20-0011] FX This work was supported by Intel Corporation and the U.S. Army Research Laboratory under the Collaborative Technology Alliance Program, Cooperative Agreement DAAD19-01-20-0011. NR 41 TC 6 Z9 6 U1 1 U2 5 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1063-6692 EI 1558-2566 J9 IEEE ACM T NETWORK JI IEEE-ACM Trans. Netw. PD AUG PY 2012 VL 20 IS 4 BP 1290 EP 1303 DI 10.1109/TNET.2011.2177473 PG 14 WC Computer Science, Hardware & Architecture; Computer Science, Theory & Methods; Engineering, Electrical & Electronic; Telecommunications SC Computer Science; Engineering; Telecommunications GA 993YD UT WOS:000307895100023 ER PT J AU Liao, DH Dogaru, T AF Liao, DaHan Dogaru, Traian TI Full-Wave Characterization of Rough Terrain Surface Scattering for Forward-Looking Radar Applications SO IEEE TRANSACTIONS ON ANTENNAS AND PROPAGATION LA English DT Article DE Finite-difference time-domain method; forward-looking radar; grazing-angle scattering; ground clutter distribution; integral equation method; rough surface; time-reversal imaging ID MONTE-CARLO SIMULATIONS; CANONICAL-GRID METHOD; NUMERICAL-SIMULATION; ELECTROMAGNETIC SCATTERING; 3-DIMENSIONAL SCATTERING; PARALLEL IMPLEMENTATION; RADIOWAVE PROPAGATION; BISTATIC SCATTERING; GRAZING-INCIDENCE; K-DISTRIBUTION AB In characterizing ground surface clutter as relevant to forward-looking radar applications, a finite-difference time-domain (FDTD)-based solver is proposed to study dielectric surface scattering at low depression angles. The solver's effectiveness and accuracy are carefully evaluated for one-dimensional surfaces by comparing Monte Carlo scattering results to those from a surface integral equation (SIE) approach for various surface parameters and incidence angles. It is demonstrated that satisfactory results can be attained at near-grazing angles for most surface parameters of interest with a relatively small simulation domain size, independent of the incidence angle. Subsequently, FDTD simulations of two-dimensional terrain surfaces are featured, along with a demonstration of the effects of ground clutter on target imaging generated by the time-reversal technique. By providing a practical full-wave simulation framework for the emulation of forward-looking radar operation and imaging, this study is intended to facilitate ongoing investigations into the detectability of discrete ground targets in the presence of distributed variable ground clutter in the near-grazing regime. C1 [Liao, DaHan; Dogaru, Traian] USA, Res Lab, Adelphi, MD 20783 USA. RP Liao, DH (reprint author), USA, Res Lab, Adelphi, MD 20783 USA. EM dahan.liao.civ@mail.mil NR 58 TC 11 Z9 14 U1 0 U2 6 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0018-926X J9 IEEE T ANTENN PROPAG JI IEEE Trans. Antennas Propag. PD AUG PY 2012 VL 60 IS 8 BP 3853 EP 3866 DI 10.1109/TAP.2012.2201076 PG 14 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA 001BW UT WOS:000308435800034 ER PT J AU Cheng, YW Lu, ST Zhang, HB Varanasi, CV Liu, J AF Cheng, Yingwen Lu, Songtao Zhang, Hongbo Varanasi, Chakrapani V. Liu, Jie TI Synergistic Effects from Graphene and Carbon Nanotubes Enable Flexible and Robust Electrodes for High-Performance Supercapacitors SO NANO LETTERS LA English DT Article DE MnO2; flexible energy storage; graphene; carbon nanotubes; supercapacitor ID ELECTROCHEMICAL CAPACITORS; ENERGY-STORAGE; MNO2; OXIDE; COMPOSITES AB Flexible and lightweight energy storage systems have received tremendous interest recently due to their potential applications in wearable electronics, roll-up displays, and other devices. To manufacture such systems, flexible electrodes with desired mechanical and electrochemical properties are critical. Herein we present a novel method to fabricate conductive, highly flexible, and robust film supercapacitor electrodes based on graphene/MnO2/CNTs nanocomposites. The synergistic effects from graphene, CNTs, and MnO2 deliver outstanding mechanical properties (tensile strength of 48 MPa) and superior electrochemical activity that were not achieved by any of these components alone. These flexible electrodes allow highly active material loading (71 wt % MnO2), areal density (8.80 mg/cm(2)), and high specific capacitance (372 F/g) with excellent rate capability for supercapacitors without the need of current collectors and binders. The film can also be wound around 0.5 mm diameter rods for fabricating full cells with high performance, showing significant potential in flexible energy storage devices. C1 [Cheng, Yingwen; Lu, Songtao; Zhang, Hongbo; Varanasi, Chakrapani V.; Liu, Jie] Duke Univ, Dept Chem, Durham, NC 27708 USA. [Cheng, Yingwen; Liu, Jie] Duke Univ, Ctr Environm Implicat NanoTechnol, Durham, NC 27708 USA. [Lu, Songtao] Harbin Inst Technol, Dept Chem, Harbin 150001, Peoples R China. [Varanasi, Chakrapani V.] Army Res Off, Durham, NC 27703 USA. RP Liu, J (reprint author), Duke Univ, Dept Chem, Durham, NC 27708 USA. EM j.liu@duke.edu RI Cheng, Yingwen/B-2202-2012; Liu, Jie/B-4440-2010 OI Cheng, Yingwen/0000-0002-0778-5504; Liu, Jie/0000-0003-0451-6111 FU Army Research Office (ARO) [W911NF-04-D-0001]; National Science Foundation (NSF); Environmental Protection Agency (EPA) under NSF [EF-0830093]; Center for the Environmental Implications of NanoTechnology (CEINT); Duke SMIF (Shared Materials Instrumentation Facilities) FX This work is in part supported by a research grant from Army Research Office (ARO) under Contract W911NF-04-D-0001 and the National Science Foundation (NSF) and the Environmental Protection Agency (EPA) under NSF Cooperative Agreement EF-0830093, Center for the Environmental Implications of NanoTechnology (CEINT). Any opinions, findings, conclusions, or recommendations expressed in this material are those of the author(s) and do not necessarily reflect the views of the ARO, NSF, or the EPA. This work has not been subjected to EPA review, and no official endorsement should be inferred. The authors also acknowledge the support from Duke SMIF (Shared Materials Instrumentation Facilities). NR 36 TC 284 Z9 291 U1 42 U2 488 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1530-6984 J9 NANO LETT JI Nano Lett. PD AUG PY 2012 VL 12 IS 8 BP 4206 EP 4211 DI 10.1021/nl301804c PG 6 WC Chemistry, Multidisciplinary; Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied; Physics, Condensed Matter SC Chemistry; Science & Technology - Other Topics; Materials Science; Physics GA 984SD UT WOS:000307211000053 PM 22823066 ER PT J AU Kuehn, JT AF Kuehn, John T. TI The Hump: America's Strategy for Keeping China in World War II SO PACIFIC HISTORICAL REVIEW LA English DT Book Review C1 [Kuehn, John T.] US Army Command, Ft Leavenworth, KS USA. [Kuehn, John T.] Gen Staff Coll, Ft Leavenworth, KS USA. RP Kuehn, JT (reprint author), US Army Command, Ft Leavenworth, KS USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU UNIV CALIFORNIA PRESS PI BERKELEY PA C/O JOURNALS & DIGITAL PUBLISHING DIVISION, 2000 CENTER ST, STE 303, BERKELEY, CA 94704-1223 USA SN 0030-8684 J9 PAC HIST REV JI Pac. Hist. Rev. PD AUG PY 2012 VL 81 IS 3 BP 498 EP 499 PG 2 WC History SC History GA 984RJ UT WOS:000307208700029 ER PT J AU Khalil, B Aung, K Mansi, IA AF Khalil, Bassem Aung, KoKo Mansi, Ishak A. TI Reporting Potential Conflicts of Interest among Authors of Professional Medical Societies' Guidelines SO SOUTHERN MEDICAL JOURNAL LA English DT Article DE conflicts of interest; ethics; medical societies ID CLINICAL-PRACTICE GUIDELINES; INDUSTRY; RECOMMENDATIONS; TRANSPARENCY; PERSPECTIVE; PHYSICIANS; DISCLOSURE AB Background: Limited attention is directed to the potential conflicts of interest (COI) of the authors of practice guidelines writing groups of professional medical societies (PMS) and industry. The objective of this study was to report the proportion of authors with potential COI among guidelines writing groups of PMS. Methods: A systematic search in PubMed to identify practice guidelines of a convenience sample of 12 publicly known PMS for a period of 3 years. The authors' disclosures of COI were reviewed for the identified guidelines Results: We identified 126 guidelines, of which 107 (85%) reported authors' disclosures of COI and 19 (15%) did not. With the exception of the US Preventive Services Task Force, all of the reviewed guidelines writing groups of PMS had potential COI to some extent. The maximum percentage of authors with potential COI varied among PMS from 25% to 100%. Conclusions: A substantial variation of percentage of authors with potential COI exists among guidelines writing groups of different PMS. Several practice guidelines of PMS fail to include the disclosures of potential COI in their published guidelines. We made several suggestions to promote the transparency of potential COI in clinical practice guidelines. C1 [Mansi, Ishak A.] Brooke Army Med Ctr, Internal Med Clin MCHE MDM, San Antonio, TX 78234 USA. Union Mem Hosp, Baltimore, MD USA. Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA. RP Mansi, IA (reprint author), Brooke Army Med Ctr, Internal Med Clin MCHE MDM, 3851 Roger Brooke Dr, San Antonio, TX 78234 USA. EM ishak.mansi@us.army.mil NR 28 TC 4 Z9 4 U1 1 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0038-4348 J9 SOUTH MED J JI South.Med.J. PD AUG PY 2012 VL 105 IS 8 BP 411 EP 415 DI 10.1097/SMJ.0b013e318256ef1d PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA 992WF UT WOS:000307810200006 PM 22864097 ER PT J AU Blackbourne, LH AF Blackbourne, Lorne H. TI Invited Commentary Recent Advances and Future Directions in Trauma Care SO SURGICAL CLINICS OF NORTH AMERICA LA English DT Editorial Material C1 USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Blackbourne, LH (reprint author), USA, Inst Surg Res, 3698 Chambers Pass, Ft Sam Houston, TX 78234 USA. EM lorne.h.blackbourne@us.army.mil NR 0 TC 0 Z9 0 U1 0 U2 0 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0039-6109 J9 SURG CLIN N AM JI Surg. Clin.-North Am. PD AUG PY 2012 VL 92 IS 4 BP XVII EP XVIII DI 10.1016/j.suc.2012.06.006 PG 2 WC Surgery SC Surgery GA 000IE UT WOS:000308379100003 PM 22850165 ER PT J AU Morrison, JJ Rasmussen, TE AF Morrison, Jonathan J. Rasmussen, Todd E. TI Noncompressible Torso Hemorrhage A Review with Contemporary Definitions and Management Strategies SO SURGICAL CLINICS OF NORTH AMERICA LA English DT Review DE Noncompressible torso hemorrhage; Trauma surgery; Military surgery; Damage-control surgery; Damage-control resuscitation ID EMERGENCY-DEPARTMENT THORACOTOMY; DAMAGE CONTROL LAPAROTOMY; ENDOVASCULAR BALLOON OCCLUSION; PENETRATING ABDOMINAL-TRAUMA; CONTROL RESUSCITATION; AORTIC OCCLUSION; PORCINE MODEL; SURVIVAL; SUPPORT; SHOCK AB Trauma resulting in hemorrhage from vascular disruption within the torso is a challenging scenario, with a propensity to be lethal in the first hour following trauma. The term noncompressible torso hemorrhage (NCTH) was only recently coined as part of contemporary studies describing the epidemiology of wounding during the wars in Afghanistan and Iraq. This article provides a contemporary review of NCTH, including a unifying definition to promote future study as well as a description of resuscitative and operative management strategies to be used in this setting, and sets a course for research to improve mortality following this vexing injury pattern. C1 [Morrison, Jonathan J.; Rasmussen, Todd E.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Morrison, Jonathan J.] Royal Ctr Def Med, Acad Dept Mil Surg & Trauma, Birmingham B15 2SQ, W Midlands, England. [Rasmussen, Todd E.] USAF, Med Serv, Sci & Technol Sect, Lackland AFB, TX 78236 USA. [Rasmussen, Todd E.] Uniformed Serv Univ Hlth Sci, Norman M Rich Dept Surg, Bethesda, MD 20814 USA. RP Rasmussen, TE (reprint author), USA, Inst Surg Res, 3400 Rawley E Chambers Ave,Suite B, Ft Sam Houston, TX 78234 USA. EM todd.rasmussen@amedd.army.mil NR 49 TC 36 Z9 36 U1 0 U2 5 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0039-6109 J9 SURG CLIN N AM JI Surg. Clin.-North Am. PD AUG PY 2012 VL 92 IS 4 BP 843 EP + DI 10.1016/j.suc.2012.05.002 PG 17 WC Surgery SC Surgery GA 000IE UT WOS:000308379100005 PM 22850150 ER PT J AU Cannon, JW Chung, KK King, DR AF Cannon, Jeremy W. Chung, Kevin K. King, David R. TI Advanced Technologies in Trauma Critical Care Management SO SURGICAL CLINICS OF NORTH AMERICA LA English DT Article DE Innovation; Trauma critical care; Ultrasound; Hemodynamic monitoring; Extracorporeal therapy; Wound management ID PULMONARY-ARTERY CATHETERS; HEART-RATE-VARIABILITY; EXTRACORPOREAL MEMBRANE-OXYGENATION; HYPOTHERMIC CARDIOPULMONARY BYPASS; RESPIRATORY-DISTRESS-SYNDROME; SURGEON-PERFORMED ULTRASOUND; PENETRATING CARDIAC WOUNDS; VACUUM-ASSISTED CLOSURE; CENTRAL VENOUS CATHETER; ACUTE LUNG INJURY AB Care of critically injured patients has evolved over the 50 years since Shoemaker established one of the first trauma units at Cook County Hospital in 1962. Modern trauma intensive care units offer a high nurse-to-patient ratio, physicians and midlevel providers who manage the patients, and technologically advanced monitors and therapeutic devices designed to optimize the care of patients. This article describes advances that have transformed trauma critical care, including bedside ultrasonography, novel patient monitoring techniques, extracorporeal support, and negative pressure dressings. It also discusses how to evaluate the safety and efficacy of future advances in trauma critical care. C1 [Cannon, Jeremy W.] San Antonio Mil Med Ctr, Div Trauma & Acute Care Surg, Ft Sam Houston, TX 78234 USA. [Cannon, Jeremy W.] Uniformed Serv Univ Hlth Sci, Dept Surg, Bethesda, MD 20814 USA. [Chung, Kevin K.] USA, Clin Div, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [King, David R.] Massachusetts Gen Hosp, Div Trauma Emergency Surg & Surg Crit Care, Boston, MA 02114 USA. [King, David R.] Harvard Univ, Sch Med, Boston, MA 02114 USA. RP Cannon, JW (reprint author), San Antonio Mil Med Ctr, Div Trauma & Acute Care Surg, 3551 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM jcannon@massmed.org OI King, David/0000-0003-1028-1478 NR 113 TC 2 Z9 2 U1 2 U2 11 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0039-6109 J9 SURG CLIN N AM JI Surg. Clin.-North Am. PD AUG PY 2012 VL 92 IS 4 BP 903 EP + DI 10.1016/j.suc.2012.04.001 PG 22 WC Surgery SC Surgery GA 000IE UT WOS:000308379100009 PM 22850154 ER PT J AU Cancio, LC Lundy, JB Sheridan, RL AF Cancio, Leopoldo C. Lundy, Jonathan B. Sheridan, Robert L. TI Evolving Changes in the Management of Burns and Environmental Injuries SO SURGICAL CLINICS OF NORTH AMERICA LA English DT Article DE Burns; Inhalation injury; Heat injury; Frostbite; Hypothermia ID ASSOCIATION PRACTICE GUIDELINES; ABDOMINAL COMPARTMENT SYNDROME; INTENSIVE INSULIN THERAPY; ACUTE KIDNEY INJURY; CARBON-MONOXIDE; THERMAL-INJURY; MILITARY CASUALTIES; ENERGY-EXPENDITURE; PEDIATRIC-PATIENTS; INHALATION INJURY AB Burns and environmental injuries are common as primary or secondary problems in survivors of natural disasters, terrorist incidents, and combat operations. In recent years, intensive military medical experience has resulted in substantial progress in treatment of these important problems. This article reviews practical applications of this new knowledge. C1 [Sheridan, Robert L.] Shriners Hosp Children, Dept Surg, Boston, MA 02114 USA. [Cancio, Leopoldo C.; Lundy, Jonathan B.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Sheridan, RL (reprint author), Shriners Hosp Children, Dept Surg, 51 Blossom St, Boston, MA 02114 USA. EM rsheridan@partners.org NR 109 TC 2 Z9 2 U1 0 U2 6 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0039-6109 J9 SURG CLIN N AM JI Surg. Clin.-North Am. PD AUG PY 2012 VL 92 IS 4 BP 959 EP + DI 10.1016/j.suc.2012.06.002 PG 29 WC Surgery SC Surgery GA 000IE UT WOS:000308379100012 PM 22850157 ER PT J AU Bailey, J Trexler, S Murdock, A Hoyt, D AF Bailey, Jeffrey Trexler, Scott Murdock, Alan Hoyt, David TI Verification and Regionalization of Trauma Systems The Impact of These Efforts on Trauma Care in the United States SO SURGICAL CLINICS OF NORTH AMERICA LA English DT Article DE Trauma systems; Verification; Regionalization ID INJURED PATIENTS; MAJOR TRAUMA; MORTALITY-RATE; FIELD TRIAGE; LEVEL I; OUTCOMES; CENTERS; GUIDELINES; US AB Efforts to develop trauma systems in the United States followed the publication of the landmark article, "Accidental Death and Disability: The Neglected Disease of Modern Society," by the National Academy of Sciences (1966) and have resulted in the implementation of a system of care for the seriously injured in most states and within the US military. In 2007, Hoyt and Coimbra published an article detailing the history, organization, and future directions of trauma systems within the United States. This article provides an update of the developments that have occurred in trauma systems in system verification and regionalization. C1 [Bailey, Jeffrey] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Trexler, Scott] San Antonio Mil Med Ctr, Dept Surg, Ft Sam Houston, TX USA. [Murdock, Alan] USAF, Med Serv, Pittsburgh, PA USA. [Murdock, Alan] Univ Pittsburgh, Pittsburgh, PA USA. [Hoyt, David] Amer Coll Surg, Dept Surg, Chicago, IL USA. RP Bailey, J (reprint author), USA, Inst Surg Res, 3611 Chambers Pass,Bldg 3611, Ft Sam Houston, TX 78234 USA. EM Jeffrey.a.bailey3@amedd.army.mil NR 52 TC 13 Z9 13 U1 1 U2 4 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0039-6109 J9 SURG CLIN N AM JI Surg. Clin.-North Am. PD AUG PY 2012 VL 92 IS 4 BP 1009 EP + DI 10.1016/j.suc.2012.04.008 PG 18 WC Surgery SC Surgery GA 000IE UT WOS:000308379100014 PM 22850159 ER PT J AU Perkins, JG Brosch, LR Beekley, AC Warfield, KL Wade, CE Holcomb, JB AF Perkins, Jeremy G. Brosch, Laura R. Beekley, Alec C. Warfield, Kelly L. Wade, Charles E. Holcomb, John B. TI Research and Analytics in Combat Trauma Care Converting Data and Experience to Practical Guidelines SO SURGICAL CLINICS OF NORTH AMERICA LA English DT Article DE Iraq; Afghanistan; Military trauma registry; Research; Clinical practice guidelines; Human research protection program ID OPERATION-ENDURING-FREEDOM; MAJOR LIMB TRAUMA; CASUALTY CARE; SURGICAL-TEAM; TOURNIQUET USE; IRAQI-FREEDOM; ORTHOPEDIC INJURIES; MILITARY CASUALTIES; HEMORRHAGE CONTROL; AFGHANISTAN AB Throughout history, wars have resulted in medical advancements, especially in trauma. Once clinical challenges are identified, they require documentation and analysis before changes to care are introduced. The wars in Afghanistan and Iraq led to the collection of clinically relevant data from the entire medical system into a formal trauma registry. Improvements in data collection and human research oversight have allowed more effective and efficient techniques to capture and analyze trauma data, which has enabled rapid development and dissemination of clinical practice guidelines in the midst of war. These data-driven experiences are influencing trauma practice patterns in the civilian community. C1 [Perkins, Jeremy G.] Walter Reed Natl Mil Med Ctr, Hematol Oncol Serv, Bethesda, MD 20889 USA. [Brosch, Laura R.] USA, Off Res Protect, Med Res & Mat Command, Ft Detrick, MD 21702 USA. [Beekley, Alec C.] Thomas Jefferson Univ, Dept Surg, Philadelphia, PA 19107 USA. [Warfield, Kelly L.] Integrated Biotherapeut Inc, Dept Vaccine Dev, Gaithersburg, MD 20878 USA. [Wade, Charles E.; Holcomb, John B.] Univ Texas Hlth Sci Ctr, Ctr Translat Injury Res, Dept Surg, Houston, TX 77030 USA. RP Perkins, JG (reprint author), Walter Reed Natl Mil Med Ctr, Hematol Oncol Serv, 8901 Wisconsin Ave, Bethesda, MD 20889 USA. EM jeremy.perkins1@us.army.mil FU US Army; NIH FX Conflict of interest statement: The authors have no conflicts of interest relevant to the subject matter of this article. Dr Wade and Dr Holcomb have received grant support from the US Army and NIH for the conduct of research related to trauma. NR 63 TC 6 Z9 6 U1 2 U2 8 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0039-6109 J9 SURG CLIN N AM JI Surg. Clin.-North Am. PD AUG PY 2012 VL 92 IS 4 BP 1041 EP + DI 10.1016/j.suc.2012.04.004 PG 15 WC Surgery SC Surgery GA 000IE UT WOS:000308379100016 PM 22850161 ER PT J AU Selakovic, Z Opsenica, D Eaton, B Retterer, C Bavari, S Burnett, JC Solaja, BA Panchal, RG AF Selakovic, Zivota Opsenica, Dejan Eaton, Brett Retterer, Cary Bavari, Sina Burnett, James C. Solaja, Bogdan A. Panchal, Rekha G. TI A Limited Structural Modification Results in a Significantly More Efficacious Diazachrysene-Based Filovirus Inhibitor SO VIRUSES-BASEL LA English DT Article DE filovirus; Ebola virus; Marburg virus; antiviral; diazachrysene; inhibitory efficacy; toxicity; small molecule ID EBOLA-VIRUS INFECTION; MORPHOLINO OLIGOMERS; PROTECTION; PRIMATES AB Ebola (EBOV) and Marburg (MARV) filoviruses are highly infectious pathogens causing deadly hemorrhagic fever in humans and non-human primates. Promising vaccine candidates providing immunity against filoviruses have been reported. However, the sporadic nature and swift progression of filovirus disease underlines the need for the development of small molecule therapeutics providing immediate antiviral effects. Herein we describe a brief structural exploration of two previously reported diazachrysene (DAAC)-based EBOV inhibitors. Specifically, three analogs were prepared to examine how slight substituent modifications would affect inhibitory efficacy and inhibitor-mediated toxicity during not only EBOV, but also MARV cellular infection. Of the three analogs, one was highly efficacious, providing IC50 values of 0.696 mu M +/- 0.13 mu M and 2.76 mu M +/- 0.21 mu M against EBOV and MARV infection, respectively, with little or no associated cellular toxicity. Overall, the structure-activity and structure-toxicity results from this study provide a framework for the future development of DAAC-based filovirus inhibitors that will be both active and non-toxic in vivo. C1 [Burnett, James C.] SAIC Frederick Inc, Frederick Natl Lab Canc Res, Frederick, MD 21702 USA. [Selakovic, Zivota; Solaja, Bogdan A.] Univ Belgrade, Belgrade 11158, Serbia. [Opsenica, Dejan] Univ Belgrade, Inst Chem Technol & Met, Belgrade 11000, Serbia. [Eaton, Brett; Retterer, Cary; Bavari, Sina; Panchal, Rekha G.] USA, Med Res Inst, Inst Infect Dis, Frederick, MD 21702 USA. RP Burnett, JC (reprint author), SAIC Frederick Inc, Frederick Natl Lab Canc Res, POB B, Frederick, MD 21702 USA. EM zivota.selakovic@gmail.com; dopsen@chem.bg.ac.rs; brett.eaton@amedd.army.mil; cary.retterer@amedd.army.mil; sina.bavari@us.army.mil; burnettjames@mail.nih.gov; bsolaja@chem.bg.ac.rs; rekha.panchal@us.army.mil OI Solaja, Bogdan/0000-0002-9975-2725 FU Joint Science and Technology Office [TMTI_00048_RD_T]; Ministry of Science and Technological Development of Serbia [172008]; Frederick National Laboratory for Cancer Research, National Institutes of Health (US) [HHSN261200800001E] FX This research was sponsored by the Joint Science and Technology Office (project designation: TMTI_00048_RD_T) and the Ministry of Science and Technological Development of Serbia (grant No. 172008). Furthermore, for J.C.B., in compliance with SAIC-Frederick, Inc. contractual requirements: this project has been funded in whole or in part with federal funds from the Frederick National Laboratory for Cancer Research, National Institutes of Health (US), under Contract No. HHSN261200800001E. NR 14 TC 4 Z9 6 U1 0 U2 3 PU MDPI AG PI BASEL PA POSTFACH, CH-4005 BASEL, SWITZERLAND SN 1999-4915 J9 VIRUSES-BASEL JI Viruses-Basel PD AUG PY 2012 VL 4 IS 8 BP 1279 EP 1288 DI 10.3390/v4081279 PG 10 WC Virology SC Virology GA 998BU UT WOS:000308213000007 PM 23012625 ER PT J AU Pegoraro, G Bavari, S Panchal, RG AF Pegoraro, Gianluca Bavari, Sina Panchal, Rekha G. TI Shedding Light on Filovirus Infection with High-Content Imaging SO VIRUSES-BASEL LA English DT Review DE filoviruses; High-Content Imaging; therapeutics; host-pathogen interactions; phenotype ID VIRUS-LIKE PARTICLES; HEMORRHAGIC-FEVER VIRUSES; FUNCTIONAL GENOMIC SCREEN; TO-CELL VARIABILITY; STRAND RNA VIRUSES; NIEMANN-PICK C1; WEST-NILE-VIRUS; EBOLA-VIRUS; MARBURG-VIRUS; HOST FACTORS AB Microscopy has been instrumental in the discovery and characterization of microorganisms. Major advances in high-throughput fluorescence microscopy and automated, high-content image analysis tools are paving the way to the systematic and quantitative study of the molecular properties of cellular systems, both at the population and at the single-cell level. High-Content Imaging (HCI) has been used to characterize host-virus interactions in genome-wide reverse genetic screens and to identify novel cellular factors implicated in the binding, entry, replication and egress of several pathogenic viruses. Here we present an overview of the most significant applications of HCI in the context of the cell biology of filovirus infection. HCI assays have been recently implemented to quantitatively study filoviruses in cell culture, employing either infectious viruses in a BSL-4 environment or surrogate genetic systems in a BSL-2 environment. These assays are becoming instrumental for small molecule and siRNA screens aimed at the discovery of both cellular therapeutic targets and of compounds with anti-viral properties. We discuss the current practical constraints limiting the implementation of high-throughput biology in a BSL-4 environment, and propose possible solutions to safely perform high-content, high-throughput filovirus infection assays. Finally, we discuss possible novel applications of HCI in the context of filovirus research with particular emphasis on the identification of possible cellular biomarkers of virus infection. C1 [Pegoraro, Gianluca; Bavari, Sina; Panchal, Rekha G.] USA, Med Res Inst Infect Dis USAMRIID, Ft Detrick, MD 21702 USA. [Pegoraro, Gianluca] PerkinElmer, Waltham, MA 02451 USA. RP Panchal, RG (reprint author), USA, Med Res Inst Infect Dis USAMRIID, 1425 Porter St, Ft Detrick, MD 21702 USA. EM gianluca.pegoraro.ctr@amedd.army.mil; sina.bavari@amedd.army.mil; rekha.panchal@amedd.army.mil OI Pegoraro, Gianluca/0000-0003-2843-9464 FU Joint Science and Technology Office Transformational Medical Technologies [TMTI0048_09_RDE_T] FX We would like to thank S. Radoshitzky for critical reading of the manuscript. This work was supported by the Joint Science and Technology Office Transformational Medical Technologies (proposal #TMTI0048_09_RDE_T). The content of this publication does not necessarily reflect the views or policies of the US Department of Defense, the US Department of the Army, the US Department of Health and Human Services or of the institutions and companies affiliated with the authors. NR 107 TC 8 Z9 8 U1 0 U2 18 PU MDPI AG PI BASEL PA POSTFACH, CH-4005 BASEL, SWITZERLAND SN 1999-4915 J9 VIRUSES-BASEL JI Viruses-Basel PD AUG PY 2012 VL 4 IS 8 BP 1354 EP 1371 DI 10.3390/v4081354 PG 18 WC Virology SC Virology GA 998BU UT WOS:000308213000013 PM 23012631 ER PT J AU Schmaljohn, CS Smith, LA Friedlander, AM AF Schmaljohn, Connie S. Smith, Leonard A. Friedlander, Arthur M. TI Military vaccines in today's environment SO HUMAN VACCINES & IMMUNOTHERAPEUTICS LA English DT Article DE vaccines; infectious diseases; military; biological warfare; bioterrorism ID DNA VACCINES; VIRUS; PERSPECTIVE AB The US military has a long and highly distinguished record of developing effective vaccines against pathogens that threaten the armed forces. Many of these vaccines have also been of significant benefit to civilian populations around the world. The current requirements for force protection include vaccines against endemic disease threats as well as against biological warfare or bioterrorism agents, to include novel or genetically engineered threats. The cost of vaccine development and the modern regulatory requirements for licensing vaccines have strained the ability of the program to maintain this broad mission. Without innovative vaccine technologies, streamlined regulatory strategies, and coordinating efforts for use in civilian populations where appropriate, the military vaccine development program is in jeopardy. C1 [Schmaljohn, Connie S.; Smith, Leonard A.; Friedlander, Arthur M.] USA, Med Res Inst Infect Dis, Off Senior Scientists, Ft Detrick, MD 21702 USA. RP Schmaljohn, CS (reprint author), USA, Med Res Inst Infect Dis, Off Senior Scientists, Ft Detrick, MD 21702 USA. EM connie.schmaljohn@us.army.mil NR 15 TC 1 Z9 1 U1 0 U2 3 PU LANDES BIOSCIENCE PI AUSTIN PA 1806 RIO GRANDE ST, AUSTIN, TX 78702 USA SN 2164-5515 J9 HUM VACC IMMUNOTHER JI Human Vaccines Immunother. PD AUG PY 2012 VL 8 IS 8 BP 1126 EP 1128 DI 10.4161/hv.20503 PG 3 WC Biotechnology & Applied Microbiology; Immunology SC Biotechnology & Applied Microbiology; Immunology GA 995UH UT WOS:000308038100025 PM 22854669 ER PT J AU Karkkainen, RL Yen, CF AF Karkkainen, Ryan L. Yen, Chian-Fong TI Dynamic modeling for rate-dependent and mode-dependent cohesive interface failure analysis SO JOURNAL OF COMPOSITE MATERIALS LA English DT Article DE Interface failure; cohesive elements ID CRACK-PROPAGATION; STRAIN-RATE; DELAMINATION; COMPOSITES; SIMULATION; FRACTURE; ELEMENTS; DAMAGE; XFEM; ZONE AB Accurate modeling of interface failure represents an important consideration for analysis cases such as adhesive bonds or phase interface failure of inhomogeneous materials. In the current work, a cohesive element based model for interface failure has been developed in the context of a butterfly-type Hopkinson Bar interface specimen. Simulation has enabled insight into the dynamic in-situ stress state and crack growth under impact for property determination and test specimen evaluation. A failure criterion has been successfully employed and agrees closely with experimental results at multiple strain rates. Strain rate effects and fracture mode effects are implemented to modify the allowable strain to failure at the interface. Calculated fracture toughness values and crack propagation rates have compared closely to published experimental results at multiple strain rates. An analytical parametric evaluation of the interface failure model has been performed to illustrate the relative importance of material properties and failure behavior. C1 [Karkkainen, Ryan L.; Yen, Chian-Fong] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Karkkainen, RL (reprint author), USA, Res Lab, 4600 Deer Creek Loop, Aberdeen Proving Ground, MD 21005 USA. EM ryan.karkkainen@us.army.mil FU Army Research Office FX Special acknowledgments for the interface specimen experimental work of C.J. Syn and W. W. Chen performed at Purdue under grant from the Army Research Office. The authors also thank B. McWilliams of the Army Research Laboratory for support and assistance. NR 22 TC 2 Z9 2 U1 3 U2 18 PU SAGE PUBLICATIONS LTD PI LONDON PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND SN 0021-9983 EI 1530-793X J9 J COMPOS MATER JI J. Compos Mater. PD AUG PY 2012 VL 46 IS 18 BP 2193 EP 2201 DI 10.1177/0021998311430543 PG 9 WC Materials Science, Composites SC Materials Science GA 995HH UT WOS:000307998300004 ER PT J AU Karkkainen, RL McWilliams, B AF Karkkainen, Ryan L. McWilliams, Brandon TI Dynamic micromechanical modeling of textile composites with cohesive interface failure SO JOURNAL OF COMPOSITE MATERIALS LA English DT Article DE Textile composites; micromechanics; interface failure ID PLAIN-WEAVE COMPOSITES; BINARY MODEL; STRAIN-RATE; DAMAGE; MECHANISMS; BEHAVIOR; CRITERIA; SYSTEMS AB Micromechanical finite element modeling has been employed to investigate the failure of several compositionally varied textile composite materials under dynamic loading. A previously developed cohesive element failure model for interface strength is employed at the phase boundary between the fiber tows and the interstitial matrix to determine the effects of interface properties on the failure behavior of a 2D plain weave and 3D orthogonal weave S2 glass/BMI composite. Thus, tow pullout and separation have been included in addition to more classical micro-level failure modes such as fiber breakage and matrix microcracking. The dynamic response of a representative volume element (RVE) is determined at strain rates of 1000 and 10,000 strain/s in an explicit finite element formulation. A parametric study has investigated compositional effects on impact strengths of two weave geometries with a relatively 'strong' versus 'weak' interface property at 10,000 and 1000 strain/s in tension and compression. The successful implementation of the cohesive failure scheme into the textile RVE framework is shown, and fundamental macro-level failure cases are investigated to relate micromechanical parametric variation to consequent strength effects. C1 [Karkkainen, Ryan L.; McWilliams, Brandon] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Karkkainen, RL (reprint author), USA, Res Lab, 4600 Deer Creek Loop, Aberdeen Proving Ground, MD 21005 USA. EM ryan.karkkainen@us.army.mil FU Army Research Office FX Special acknowledgments for the interface specimen experimental work of C.J. Syn and W. W. Chen performed at Purdue under grant from the Army Research Office. Thanks to C. F. Yen and B. Boesl of the Army Research Laboratory for support and assistance. NR 35 TC 1 Z9 1 U1 2 U2 21 PU SAGE PUBLICATIONS LTD PI LONDON PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND SN 0021-9983 J9 J COMPOS MATER JI J. Compos Mater. PD AUG PY 2012 VL 46 IS 18 BP 2203 EP 2218 DI 10.1177/0021998311430544 PG 16 WC Materials Science, Composites SC Materials Science GA 995HH UT WOS:000307998300005 ER PT J AU Walsh, GP Dela Cruz, EC Abalos, RM Tan, EV Fajardo, TT Villahermosa, LG Cellona, RV Balagon, MV White, VA Saunderson, PR Walsh, DS AF Walsh, Gerald P. Dela Cruz, Eduardo C. Abalos, Rodolfo M. Tan, Esterlina V. Fajardo, Tranquilino T. Villahermosa, Laarni G. Cellona, Roland V. Balagon, Maria V. White, Valerie A. Saunderson, Paul R. Walsh, Douglas S. TI Limited Susceptibility of Cynomolgus Monkeys (Macaca fascicularis) to Leprosy after Experimental Administration of Mycobacterium leprae SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID SOOTY MANGABEY MONKEYS; ANTILEPROSY PROTECTIVE VACCINATION; SIMIAN IMMUNODEFICIENCY VIRUS; PHENOLIC GLYCOLIPID-I; RHESUS-MONKEYS; IMMUNOLOGICAL OBSERVATIONS; NECROPSY FINDINGS; RESPONSES; BCG; TRANSMISSION AB Cynomolgus monkeys are a useful model for human tuberculosis, but susceptibility to M. leprae is unknown. A cynomolgus model of leprosy could increase understanding of pathogenesis importantly, neuritis and nerve-damaging reactions. We administered viable Mycobacterium leprae to 24 cynomolgus monkeys by three routes, with a median follow-up period of 6 years (range = 1-19 years) involving biopsies, nasal smears, antiphenolic glycolipid-1 (PGL-1) antibody serology, and lepromin skin testing. Most developed evanescent papules at intradermal M. leprae inoculation sites that, on biopsy, showed a robust cellular immune response akin to a lepromin skin test reaction; many produced PGL-1 antibodies. At necropsy, four monkeys, without cutaneous or gross neurological signs of leprosy but with elevated PGL-1 antibodies, including three with nasal smears (+) for acid fast bacilli (AFB), showed histological features, including AFB, suggestive of leprosy at several sites. Overall, however, cynomolgus monkeys seem minimally susceptible to leprosy after experimental M. leprae administration. C1 [Walsh, Douglas S.] Armed Forces Res Inst Med Sci, Dept Immunol & Med, USA, Bangkok 10400, Thailand. Cebu Leprosy & TB Res Fdn, Cebu, Philippines. [White, Valerie A.] Vancouver Gen Hosp, Dept Pathol & Lab Med, Vancouver, BC, Canada. [Walsh, Gerald P.; Dela Cruz, Eduardo C.; Abalos, Rodolfo M.; Tan, Esterlina V.; Fajardo, Tranquilino T.; Villahermosa, Laarni G.; Cellona, Roland V.; Balagon, Maria V.; Saunderson, Paul R.] Leprosy Res Ctr, Cebu, Philippines. RP Walsh, DS (reprint author), Armed Forces Res Inst Med Sci, Dept Immunol & Med, USA, 315-6 Rajvithi Rd, Bangkok 10400, Thailand. EM csc_epi@yahoo.com; val.white@ych.ca; douglas.walsh@afrims.org NR 33 TC 3 Z9 3 U1 0 U2 3 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD AUG PY 2012 VL 87 IS 2 BP 327 EP 336 DI 10.4269/ajtmh.2012.11-0780 PG 10 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 984QA UT WOS:000307204900023 PM 22855766 ER PT J AU Vamvoudakis, KG Lewis, FL Hudas, GR AF Vamvoudakis, Kyriakos G. Lewis, Frank L. Hudas, Greg R. TI Multi-agent differential graphical games: Online adaptive learning solution for synchronization with optimality SO AUTOMATICA LA English DT Article DE Graphical games; Cooperative Hamilton-Jacobi equations; Policy iteration; Cooperative Nash-equilibrium; Best response; Consensus ID COOPERATIVE CONTROL; CONSENSUS PROBLEMS; SYSTEMS; COORDINATION; ALGORITHMS; NETWORKS; TOPOLOGY; AGENTS AB Multi-agent systems arise in several domains of engineering and can be used to solve problems which are difficult for an individual agent to solve. Strategies for team decision problems, including optimal control, N-player games (H-infinity control and non-zero sum), and so on are normally solved for off-line by solving associated matrix equations such as the coupled Riccati equations or coupled Hamilton-Jacobi equations. However, using that approach players cannot change their objectives online in real time without calling for a completely new off-line solution for the new strategies. Therefore, in this paper we bring together cooperative control, reinforcement learning, and game theory to present a multiagent formulation for the online solution of team games. The notion of graphical games is developed for dynamical systems, where the dynamics and performance indices for each node depend only on local neighbor information. It is shown that standard definitions for Nash equilibrium are not sufficient for graphical games and a new definition of "Interactive Nash Equilibrium" is given. We give a cooperative policy iteration algorithm for graphical games that converges to the best response when the neighbors of each agent do not update their policies, and to the cooperative Nash equilibrium when all agents update their policies simultaneously. This is used to develop methods for online adaptive learning solutions of graphical games in real time along with proofs of stability and convergence. (C) 2012 Elsevier Ltd. All rights reserved. C1 [Vamvoudakis, Kyriakos G.] Univ Calif Santa Barbara, Ctr Control Dynam Syst & Computat CCDC, Santa Barbara, CA 93106 USA. [Lewis, Frank L.] Univ Texas Arlington, Automat & Robot Res Inst, Ft Worth, TX 76118 USA. [Hudas, Greg R.] USA, RDECOM TARDEC, Joint Ctr Robot JCR, Warren, MI 48397 USA. RP Vamvoudakis, KG (reprint author), Univ Calif Santa Barbara, Ctr Control Dynam Syst & Computat CCDC, Santa Barbara, CA 93106 USA. EM kyriakos@ece.ucsb.edu; lewis@uta.edu; greg.hudas@us.army.mil FU National Science Foundation [ECS-1128050]; Army Research Office [W91NF-05-1-0314]; Air Force Office of Scientific Research [FA9550-09-1-0278] FX This work was supported by the National Science Foundation ECS-1128050, the Army Research Office W91NF-05-1-0314 and the Air Force Office of Scientific Research FA9550-09-1-0278. The material in this paper was partially presented at the 50th IEEE Conference on Decision and Control (CDC 2011), December 12-15, 2011, Orlando, Florida, USA. This paper was recommended for publication in revised form by Associate Editor Shuzhi Sam Ge under the direction of Editor Miroslav Krstic. NR 43 TC 47 Z9 52 U1 1 U2 29 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0005-1098 EI 1873-2836 J9 AUTOMATICA JI Automatica PD AUG PY 2012 VL 48 IS 8 BP 1598 EP 1611 DI 10.1016/j.automatica.2012.05.074 PG 14 WC Automation & Control Systems; Engineering, Electrical & Electronic SC Automation & Control Systems; Engineering GA 991FZ UT WOS:000307688200011 ER PT J AU Torres, DM Williams, CD HarrisonO, SA AF Torres, Dawn M. Williams, Christopher D. HarrisonO, Stephen A. TI Features, Diagnosis, and Treatment of Nonalcoholic Fatty Liver Disease SO CLINICAL GASTROENTEROLOGY AND HEPATOLOGY LA English DT Article DE Diagnosis; Epidemiology; Cancer Risk; Mechanisms ID PLACEBO-CONTROLLED TRIAL; RANDOMIZED CONTROLLED-TRIAL; OBSTRUCTIVE SLEEP-APNEA; MAGNETIC-RESONANCE ELASTOGRAPHY; SERUM AMINOTRANSFERASE LEVELS; DOSE URSODEOXYCHOLIC ACID; INDUCED HEPATIC STEATOSIS; GASTRIC BYPASS-SURGERY; NECROSIS-FACTOR-ALPHA; VITAMIN-D DEFICIENCY AB As the global incidence of obesity has increased, nonalcoholic fatty liver disease (NAFLD) has become a worldwide health concern. NAFLD occurs in children and adults of all ethnicities and includes isolated fatty liver and nonalcoholic steatohepatitis (NASH). Patients with NASH are at risk for developing cirrhosis, hepatic decompensation, and hepatocellular carcinoma and have increased all-cause mortality. NAFLD is associated with a variety of clinical conditions and is an independent risk factor for hepatocellular carcinoma. The pathogenesis of NAFLD and the specific steps that lead to NASH and advanced fibrosis are not fully understood, although researchers have found that a combination of environmental, genetic, and metabolic factors lead to advanced disease. There have been improvements in noninvasive radiographic methods to diagnose NAFLD, especially for advanced disease. However, liver biopsy is still the standard method of diagnosis for NASH. There are many challenges to treating patients with NASH, and no therapies have been approved by the U. S. Food and Drug Administration; multimodal approaches are being developed and becoming the standard of care. We review pathogenesis and treatment approaches for the West's largest liver-related public health concern. C1 [Torres, Dawn M.] Walter Reed Natl Mil Med Ctr, Dept Med, Div Gastroenterol, Bethesda, MD USA. [Williams, Christopher D.; HarrisonO, Stephen A.] San Antonio Mil Med Ctr, Dept Med, Div Gastroenterol, Ft Sam Houston, TX USA. RP HarrisonO, SA (reprint author), Brooke Army Med Ctr, Div Gastroenterol & Hepatol, Dept Med, Ft Sam Houston, TX 78234 USA. EM stephen.harrison@amedd.army.mil FU Genentech; Merck; BMS; Rottapharm; Mochida FX This author discloses the following: Dr Harrison received research support from Genentech, Merck, BMS, Rottapharm, and Mochida and is on the Ad hoc advisory board for Amylin Pharmaceuticals. The remaining authors disclose no conflicts. NR 261 TC 87 Z9 95 U1 2 U2 32 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1542-3565 J9 CLIN GASTROENTEROL H JI Clin. Gastroenterol. Hepatol. PD AUG PY 2012 VL 10 IS 8 BP 837 EP 858 DI 10.1016/j.cgh.2012.03.011 PG 22 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 984WL UT WOS:000307223400006 PM 22446927 ER PT J AU Kernan, L Ito, S Shirazi, F Boesen, K AF Kernan, Leah Ito, Satoru Shirazi, Farshad Boesen, Keith TI Fatal gastrointestinal hemorrhage after a single dose of dabigatran SO CLINICAL TOXICOLOGY LA English DT Article DE Pradaxa; Gastrointestinal hemorrhage; Gastric ulcer; Renal insufficiency; Anticoagulation ID ATRIAL-FIBRILLATION; P-GLYCOPROTEIN; WARFARIN AB Introduction. Dabigatran (Pradaxa) is a new oral anticoagulant approved by the Food and Drug Administration (FDA), available internationally and indicated as an alternative to warfarin for the prevention of stroke and systemic embolism in patients with nonvalvular atrial fibrillation. Dabigatran does not require laboratory monitoring and its kinetics allow for a more rapid onset of action with a time to peak concentration of 1.25-1.5 h. We are reporting a fatality resulting from gastrointestinal bleeding after the ingestion of a single dose of dabigatran 150 mg. Case details. A 92-year-old man with a medical history of chronic obstructive pulmonary disease, hypothyroidism, and atrial flutter presented to the emergency department with complaints of weakness and rectal bleeding. He was seen by his Cardiologist the day before and was found to be in new atrial fibrillation. He was prescribed dabigatran 150 mg twice daily for anticoagulation therapy. He took one dose of dabigatran 150 mg at 2200 and woke up the following morning before 0900 with profuse rectal bleeding. The initial vital signs in the emergency department, approximately 11 h after ingestion, were heart rate 72 beats/min, blood pressure 62/30 mmHg, and lab work showed hemoglobin 9.9 g/dL, international normalization ratio (INR) 1.99, blood urea nitrogen (BUN) 66 mg/dL, and creatinine (SCr) 1.4 mg/dL (creatinine clearance (CrCl) 24.2 mL/min). He was resuscitated with intravenous fluids, two units of packed red blood cells, two units of fresh frozen plasma, platelets, and vitamin K 10 mg intravenously. He was also given an unknown dose of erythromycin early in his hospital stay. An actively bleeding gastric ulcer was discovered and treated with local epinephrine injections. Approximately 48 h after his exposure, he received an additional two units of blood to treat his decreasing blood pressure (98/41 mmHg). On day three, his hemoglobin and hematocrit were stable at 10 g/dL and 30%, INR 1.6, he was extubated and off vasoactive medications. Day six of hospitalization, he began having maroon stools, his hemoglobin decreased to 8.1 g/dL and his platelets to 81 x 1000/mcL. On day seven, the hemoglobin decreased to 6.4 mg/dL. Despite aggressive resuscitative efforts and supportive care, he died. Discussion. This case demonstrates the potential of a single dose of dabigatran 150 mg to result in a fatal gastrointestinal hemorrhage. This patient was started on the maximum dose with a CrCl 33.9 mL/min and on admission CrCl 24.2 mL/min, suggesting underlying renal insufficiency. C1 [Boesen, Keith] Univ Arizona, Coll Pharm, Arizona Poison & Drug Informat Ctr, CSPI, Tucson, AZ 85721 USA. [Kernan, Leah] USA, Carl R Darnall Army Med Ctr, Dept Emergency Med, Fr Hood, TX USA. RP Boesen, K (reprint author), Univ Arizona, Coll Pharm, Arizona Poison & Drug Informat Ctr, CSPI, 1295 N Martin, Tucson, AZ 85721 USA. EM boesen@pharmacy.arizona.edu NR 9 TC 23 Z9 25 U1 2 U2 3 PU INFORMA HEALTHCARE PI NEW YORK PA 52 VANDERBILT AVE, NEW YORK, NY 10017 USA SN 1556-3650 J9 CLIN TOXICOL JI Clin. Toxicol. PD AUG PY 2012 VL 50 IS 7 BP 571 EP 573 DI 10.3109/15563650.2012.705290 PG 3 WC Toxicology SC Toxicology GA 985WB UT WOS:000307300100007 PM 22800505 ER PT J AU Heiner, JD Varney, SM Bebarta, VS Bothwell, JD Cronin, AJ AF Heiner, Jason D. Varney, Shawn M. Bebarta, Vikhyat S. Bothwell, Jason D. Cronin, Aaron J. TI Clinical effects and antivenom use for snakebite victims treated at three US hospitals in Afghanistan SO CLINICAL TOXICOLOGY LA English DT Meeting Abstract DE Antivenom; Snake bite; Envenomation C1 [Heiner, Jason D.; Varney, Shawn M.; Bebarta, Vikhyat S.] San Antonio Mil Med Ctr, San Antonio, TX USA. [Bothwell, Jason D.] Madigan Army Med Ctr, Seattle, WA USA. [Cronin, Aaron J.] Womack Army Med Ctr, Ft Bragg, NC USA. RI Bebarta, Vikhyat/M-1513-2015; bebarta, vikhyat/K-3476-2015 NR 0 TC 0 Z9 0 U1 0 U2 1 PU INFORMA HEALTHCARE PI NEW YORK PA 52 VANDERBILT AVE, NEW YORK, NY 10017 USA SN 1556-3650 J9 CLIN TOXICOL JI Clin. Toxicol. PD AUG PY 2012 VL 50 IS 7 MA 175 BP 652 EP 652 PG 1 WC Toxicology SC Toxicology GA 985WB UT WOS:000307300100183 ER PT J AU Barry, JD Hanson, CE McCall, S Merril, J AF Barry, J. Dave Hanson, Chis E. McCall, Suzanne Merril, Jerry TI Evaluation of crotalidae polyvalent fab antivenom for the treatment of Middle Eastern and South Asian Viperidae envenomation in a murine model (Mus musculus) SO CLINICAL TOXICOLOGY LA English DT Meeting Abstract DE Antivenom; Snake bite; Venom C1 [Hanson, Chis E.; McCall, Suzanne; Merril, Jerry] Brooke Army Med Ctr, San Antonio, TX USA. [Barry, J. Dave] USN, Med Ctr Portsmouth, Portsmouth, VA USA. NR 0 TC 0 Z9 0 U1 2 U2 2 PU INFORMA HEALTHCARE PI NEW YORK PA 52 VANDERBILT AVE, NEW YORK, NY 10017 USA SN 1556-3650 J9 CLIN TOXICOL JI Clin. Toxicol. PD AUG PY 2012 VL 50 IS 7 MA 262 BP 692 EP 692 PG 1 WC Toxicology SC Toxicology GA 985WB UT WOS:000307300100270 ER PT J AU Vasan, S Michael, NL AF Vasan, Sandhya Michael, Nelson L. TI Improved outlook on HIV-1 prevention and vaccine development SO EXPERT OPINION ON BIOLOGICAL THERAPY LA English DT Review DE AIDS; clinical trials; HIV; vaccine ID HUMAN-IMMUNODEFICIENCY-VIRUS; TEST-OF-CONCEPT; CD8(+) T-CELLS; GENITAL ULCER DISEASE; NEUTRALIZING ANTIBODY; MALE CIRCUMCISION; IMMUNE-RESPONSES; RHESUS MACAQUES; EFFICACY TRIAL; SUBTYPE-B AB Introduction: The development of an effective vaccine against HIV-1 has been challenging but recent advances in both the HIV prevention landscape and the partial efficacy of the recent RV144 vaccine efficacy trial in Thailand provide hope for an improved arsenal of approaches to prevent HIV-1 transmission. Areas covered: This review describes recent advances in HIV-1 prevention such as circumcision, microbicides and pre-exposure prophylaxis with antiretroviral therapy, but focuses mainly on the current state of HIV-1 vaccine development in the post-RV144 era. Expert opinion: The field of HIV-1 vaccine development has been plagued by the unprecedented challenges involved with designing a vaccine effective in preventing transmission of a retrovirus, due in part to sequence diversity, retroviral integration into host chromosomes, establishment of reservoir sites and glycosylation shielding of the HIV-1 envelope. The partial efficacy of the recent RV144 vaccine trial in Thailand may allow for better understanding of immune correlates of infection risk, which could enable iterative improvements to vaccine regimens in the development pipeline. In parallel, a number of promising vaccine strategies incorporating viral vectors, novel immunogens, delivery systems and adjuvants are advancing in clinical development. Vaccine development must occur in parallel with continued advances in HIV-1 prevention. C1 [Michael, Nelson L.] Armed Forces Res Inst Med Sci, US Mil HIV Res Program MHRP, USA, Bangkok 10400, Thailand. RP Michael, NL (reprint author), Armed Forces Res Inst Med Sci, US Mil HIV Res Program MHRP, USA, Bangkok 10400, Thailand. EM nmichael@hivresearch.org FU U.S. Army Medical Research (MRMC) and Materiel Command; National Institutes of Allergy and Infectious Diseases [Y1-AI-2642-16, W81XWH-07-2-0067] FX This work was supported by intramural funding from the U.S. Army Medical Research (MRMC) and Materiel Command and from the National Institutes of Allergy and Infectious Diseases (Y1-AI-2642-16) via a cooperative agreement between MRMC and the Henry Jackson Foundation (W81XWH-07-2-0067). The views expressed herein are those of the authors do not reflect official views of the U.S. Departments of the Army or Defense. The authors have no further interests to declare. NR 117 TC 2 Z9 2 U1 0 U2 14 PU INFORMA HEALTHCARE PI LONDON PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND SN 1471-2598 J9 EXPERT OPIN BIOL TH JI Expert Opin. Biol. Ther. PD AUG PY 2012 VL 12 IS 8 BP 983 EP 994 DI 10.1517/14712598.2012.688020 PG 12 WC Biotechnology & Applied Microbiology; Medicine, Research & Experimental SC Biotechnology & Applied Microbiology; Research & Experimental Medicine GA 984QF UT WOS:000307205400002 PM 22583109 ER PT J AU Ward, DL Clemens, BJ Clugston, D Jackson, AD Moser, ML Peery, C Statler, DP AF Ward, David L. Clemens, Benjamin J. Clugston, David Jackson, Aaron D. Moser, Mary L. Peery, Chris Statler, David P. TI Translocating Adult Pacific Lamprey within the Columbia River Basin: State of the Science SO FISHERIES LA English DT Article ID ANADROMOUS PARASITIC LAMPREY; LAMPETRA-TRIDENTATA; BRITISH-COLUMBIA; FRASER-RIVER; BODY-SIZE; POPULATION; EXTINCTION; UPSTREAM; BIOLOGY; OREGON AB The Pacific lamprey (Entosphenus tridentatus) is in decline in the Columbia River Basin, and translocating adult lamprey to bypass difficult migration corridors has been implemented since 2000. We describe and report results from two current translocation programs, provide context for use of translocation, and discuss potential benefits, risks, and uncertainties. Both translocation programs appear to have increased the number of spawning adults and the presence of larvae and juveniles; however, any subsequent increase in naturally spawning adults will require at least one, and likely more, generations to be realized. It was seen that the number of adults entering the Umatilla River increased beginning four years after the first translocations. Potential benefits of translocation programs are increased pheromone production by ammocoetes to attract adults, increased lamprey distribution and abundance in target areas, increased marine-derived nutrients, and promotion of tribal culture. Potential risks include disruption of population structure and associated genetic adaptations, disease transmission, and depletion of donor stocks. C1 [Ward, David L.] HDR Engn Inc, Portland, OR 97204 USA. [Clemens, Benjamin J.] Oregon State Univ, Dept Fisheries & Wildlife, Corvallis, OR 97331 USA. [Clugston, David] USA, Corps Engn, Portland, OR 97209 USA. [Jackson, Aaron D.] Confederated Tribes Umatilla Indian Reservat, Pendleton, OR 97801 USA. [Moser, Mary L.] NOAA, Natl Marine Fisheries Serv, NW Fisheries Sci Ctr, Seattle, WA 98112 USA. [Peery, Chris] US Fish & Wildlife Serv, Moscow, ID 83844 USA. RP Ward, DL (reprint author), HDR Engn Inc, Portland, OR 97204 USA. EM david.ward@hdrinc.com NR 33 TC 8 Z9 9 U1 1 U2 34 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA SN 0363-2415 J9 FISHERIES JI Fisheries PD AUG PY 2012 VL 37 IS 8 BP 351 EP 361 DI 10.1080/03632415.2012.704818 PG 11 WC Fisheries SC Fisheries GA 992VX UT WOS:000307809400003 ER PT J AU Schwartz, MD Betancourt, JL Weltzin, JF AF Schwartz, Mark D. Betancourt, Julio L. Weltzin, Jake F. TI From Caprio's lilacs to the USA National Phenology Network SO FRONTIERS IN ECOLOGY AND THE ENVIRONMENT LA English DT Article AB Continental-scale monitoring is vital for understanding and adapting to temporal changes in seasonal climate and associated phenological responses. The success of monitoring programs will depend on recruiting, retaining, and managing members of the public to routinely collect phenological observations according to standardized protocols. Here, we trace the development of infrastructure for phenological monitoring in the US, culminating in the USA National Phenology Network, a program that engages scientists and volunteers. C1 [Schwartz, Mark D.] Univ Wisconsin, Dept Geog, Milwaukee, WI 53201 USA. [Betancourt, Julio L.; Weltzin, Jake F.] US Geol Survey, Tucson, AZ USA. [Weltzin, Jake F.] USA, Natl Coordinating Off, Natl Phenol Network, Tucson, AZ USA. RP Schwartz, MD (reprint author), Univ Wisconsin, Dept Geog, Milwaukee, WI 53201 USA. EM mds@uwm.edu FU US Geological Survey; University of Arizona; University of Wisconsin-Milwaukee; Wildlife Society; US National Park Service; National Oceanic and Atmospheric Administration; National Aeronautics and Space Administration; National Science Foundation [IOS-0639794]; Oak Ridge National Laboratory; US Fish and Wildlife Service FX We dedicate this contribution to the memory of the late Joseph M Caprio. The USA-NPN gratefully acknowledges sponsoring organizations: US Geological Survey, University of Arizona, University of Wisconsin-Milwaukee, The Wildlife Society, US National Park Service, National Oceanic and Atmospheric Administration, National Aeronautics and Space Administration, National Science Foundation (IOS-0639794), Oak Ridge National Laboratory, and US Fish and Wildlife Service. Staff from the USA-NPN National Coordinating Office collaboratively developed the description of the contemporary network in the body of the text and in Web Panel 2. NR 7 TC 42 Z9 42 U1 1 U2 38 PU ECOLOGICAL SOC AMER PI WASHINGTON PA 1990 M STREET NW, STE 700, WASHINGTON, DC 20036 USA SN 1540-9295 J9 FRONT ECOL ENVIRON JI Front. Ecol. Environ. PD AUG PY 2012 VL 10 IS 6 SI SI BP 324 EP 327 DI 10.1890/110281 PG 4 WC Ecology; Environmental Sciences SC Environmental Sciences & Ecology GA 983VK UT WOS:000307146600012 ER PT J AU Ma, L Chu, D Chen, RR AF Ma, Liang Chu, Deryn Chen, Rongrong TI Comparison of ethanol electro-oxidation on Pt/C and Pd/C catalysts in alkaline media SO INTERNATIONAL JOURNAL OF HYDROGEN ENERGY LA English DT Article DE Ethanol electro-oxidation; Alkaline media; Carbon-supported Pt; Carbon-supported Pd; Temperature; Mechanism ID ANION-EXCHANGE MEMBRANES; ELECTROLYTE FUEL-CELLS; POLYMER-ELECTROLYTE; ELECTROCATALYTIC OXIDATION; METHANOL ELECTROOXIDATION; ELECTROCHEMICAL-BEHAVIOR; ALCOHOL OXIDATION; MASS-SPECTROMETRY; OXYGEN REDUCTION; PALLADIUM AB The ethanol electro-oxidation behaviors of Pt/C and Pd/C in alkaline media were compared using potentiodynamic and potentiostatic methods. Various ethanol and alkaline concentrations were studied. In addition, the temperature effect of ethanol oxidation was investigated. The Pd/C showed a higher activity toward ethanol oxidation than the Pt/C, especially in the potentiostatic measurement. This is mainly due to the higher oxyphilic characteristics of the Pd/C and the relatively inert nature of the Pd/C on C-C bond cleavage. The apparent activation energies of the ethanol oxidation on the Pd/C in alkaline media varied from 26.6 to 30.4 kJ mol(-1), depending on the potentials. The Tafel slopes could be divided into two parts on both catalysts: at low overpotentials, the Tafel slope on both the Pt/C and the Pd/C was close to 120 mV dec(-1) at all temperatures; at high overpotentials, the Tafel slope was ca. 260 mV dec(-1) on the Pd/C at all temperatures, but was much higher on the Pt/C, especially at high temperatures. Based on these results, it is concluded that Pd/C has less poisoning effect and higher activity than Pt/C for selective oxidation of ethanol to acetate. Copyright (C) 2012, Hydrogen Energy Publications, LLC. Published by Elsevier Ltd. All rights reserved. C1 [Ma, Liang; Chen, Rongrong] Indiana Univ Purdue Univ, Richard G Lugar Ctr Renewable Energy, Indianapolis, IN 46202 USA. [Chu, Deryn] USA, Res Lab, Adelphi, MD 20783 USA. RP Chen, RR (reprint author), Indiana Univ Purdue Univ, Richard G Lugar Ctr Renewable Energy, Indianapolis, IN 46202 USA. EM rochen@iupui.edu RI Ma, Liang/H-6226-2013 FU U.S. Army Research Lab [W911NF-10-2-0075] FX This work was supported by the U.S. Army Research Lab (Grant No. W911NF-10-2-0075). NR 50 TC 74 Z9 74 U1 8 U2 116 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0360-3199 J9 INT J HYDROGEN ENERG JI Int. J. Hydrog. Energy PD AUG PY 2012 VL 37 IS 15 BP 11185 EP 11194 DI 10.1016/j.ijhydene.2012.04.132 PG 10 WC Chemistry, Physical; Electrochemistry; Energy & Fuels SC Chemistry; Electrochemistry; Energy & Fuels GA 989ZL UT WOS:000307600700022 ER PT J AU Chan, CM Shorr, AF Perkins, JG AF Chan, Chee M. Shorr, Andrew F. Perkins, Jeremy G. TI Factors associated with acute lung injury in combat casualties receiving massive blood transfusions: A retrospective analysis SO JOURNAL OF CRITICAL CARE LA English DT Article DE Acute lung injury; Massive transfusions; Warm fresh whole blood; Risk factors; Combat casualties; Outcomes; Penetrating wounds ID FRESH WHOLE-BLOOD; RESPIRATORY-DISTRESS-SYNDROME; HEMORRHAGIC-SHOCK; CELL TRANSFUSION; TRAUMA PATIENTS; CLASSIFICATION; DISEASE; IMPACT; TRALI AB Purpose: We sought to determine if use of warm fresh whole blood (WFWB), rather than blood component therapy, alters rates of acute lung injury (ALI) in patients with trauma. Materials and Methods: We retrospectively analyzed rates of ALI in patients undergoing massive blood transfusions while at a combat support hospital. Patients with ALI were compared with those not developing ALI with respect to demographics, trauma type, severity of illness, crystalloid volume given, and exposure to WFWB. Logistic regression was used to identify variables associated with ALI. Results: The cohort included 591 subjects (mean age, 28 +/- 8.1 years; male, 96.7%). Acute lung injury occurred in 11.2%, and 34.4% received WFWB. After adjusting for the type of trauma, severity of illness, and volume of crystalloid administered, WFWB remained independently associated with ALI (adjusted odds ratio [AOR], 1.06; 95% confidence interval [CI], 1.00-1.13). Nearly two thirds of persons with ALI never received WFWB; factors associated with the use of WFWB were also examined. Severity of illness (AOR, 1.18; 95% CI, 1.02-1.35), crystalloid volume (AOR, 1.12; 95% CI, 1.06-1.18), recombinant factor VIIa use (AOR, 1.94; 95% CI, 1.06-3.57), and US citizenship (AOR, 3.06; 95% CI, 1.74-5.37) correlated with WFWB use. Conclusions: Warm fresh whole blood may be associated with an increased risk of ALI, but this is confounded by increased injury and crystalloid use in patients receiving WFWB. (C) 2012 Elsevier Inc. All rights reserved. C1 [Chan, Chee M.; Shorr, Andrew F.] Georgetown Univ, Med Ctr, Washington Hosp Ctr, Pulm & Crit Care Dept, Washington, DC 20010 USA. [Perkins, Jeremy G.] Walter Reed Army Med Ctr, Dept Hematol & Oncol, Washington, DC 20307 USA. RP Chan, CM (reprint author), Georgetown Univ, Med Ctr, Washington Hosp Ctr, Pulm & Crit Care Dept, Washington, DC 20010 USA. EM chee262@hotmail.com NR 30 TC 2 Z9 2 U1 0 U2 1 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0883-9441 J9 J CRIT CARE JI J. Crit. Care PD AUG PY 2012 VL 27 IS 4 AR 419.e7 DI 10.1016/j.jcrc.2011.11.010 PG 8 WC Critical Care Medicine SC General & Internal Medicine GA 984VS UT WOS:000307221100024 PM 22227085 ER PT J AU Baer, DG Rasmussen, TE Blackbourne, LH AF Baer, David G. Rasmussen, Todd E. Blackbourne, Lorne H. TI Foreword for 2011 Advanced Technology Applications for Combat Casualty Care SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY LA English DT Editorial Material C1 [Baer, David G.; Rasmussen, Todd E.; Blackbourne, Lorne H.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Baer, DG (reprint author), USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. EM David.G.Baer@us.army.mil NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 2163-0755 J9 J TRAUMA ACUTE CARE JI J. Trauma Acute Care Surg. PD AUG PY 2012 VL 73 SU 1 BP S1 EP S2 DI 10.1097/TA.0b013e3182605fbc PG 2 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 992VP UT WOS:000307808500001 PM 22847076 ER PT J AU Bowman, WJ Nesbitt, ME Therien, SP AF Bowman, W. Joseph Nesbitt, Michael E. Therien, Sean P. TI The effects of standardized trauma training on prehospital pain control: Have pain medication administration rates increased on the battlefield? SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY LA English DT Article DE Prehospital; pain; analgesia; combat; military ID POSTTRAUMATIC-STRESS-DISORDER; COMBAT CASUALTY CARE; MANAGEMENT AB BACKGROUND: The US Military has served in some of the most austere locations in the world. In this ever-changing environment, units are organized into smaller elements operating in very remote areas. This often results in longer evacuation times, which can lead to a delay in pain management if treatment is not initiated in the prehospital setting. Early pain control has become an increasingly crucial military prehospital task and must be controlled from the pain-initiating event. The individual services developed their standardized trauma training based on the recommendations by Frank Butler and the Defense Health Board Committee on Tactical Combat Casualty Care. This training stresses evidence-based treatment modalities, including pain control, derived from casualty injury analysis. Inadequate early pain control may lead to multiple acute and potentially chronic effects. These effects encompass a wide range from changes in blood pressure to delayed wound healing and posttraumatic stress disorder. Therefore, it is essential that pain be addressed in the prehospital environment. METHODS: Institutional Review Board approval was obtained to conduct a retrospective Joint Theater Trauma Registry comparative study evaluating whether standardized trauma training increased prehospital pain medication administration between 2007 and 2009. These years were selected on the basis of mandatory training initiation dates and available Joint Theater Trauma Registry records. Records were analyzed for all US prehospital trauma cases with documented pain medication administration from Operations Enduring Freedom and Iraqi Freedom for the specified years. RESULTS: Data analysis revealed 232 patients available for review (102 for 2007 and 130 for 2009). A statistically significant prehospital pain treatment increase was noted, from 3.1% in 2007 to 6.7% in 2009 (p < 0.0005; 95% confidence interval, 2.39-4.93). CONCLUSION: Standardized trauma training has increased the administration of prehospital pain medication and the awareness of the importance of early pain control. (J Trauma Acute Care Surg. 2012;73: S43-S48. Copyright (c) 2012 by Lippincott Williams & Wilkins) C1 [Bowman, W. Joseph; Nesbitt, Michael E.] San Antonio Mil Med Ctr, Dept Emergency Med, Ft Sam Houston, TX USA. [Therien, Sean P.] William Beaumont Army Med Ctr, Dept Emergency Med, El Paso, TX 79920 USA. RP Bowman, WJ (reprint author), Bassett St, Ft Bragg, NC 28307 USA. EM w.joseph.bowman@mail.us.army.mil NR 33 TC 3 Z9 3 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 2163-0755 J9 J TRAUMA ACUTE CARE JI J. Trauma Acute Care Surg. PD AUG PY 2012 VL 73 SU 1 BP S43 EP S48 DI 10.1097/TA.0b013e3182606148 PG 6 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 992VP UT WOS:000307808500008 PM 22847093 ER PT J AU Cap, AP Spinella, PC Borgman, MA Blackbourne, LH Perkins, JG AF Cap, Andrew P. Spinella, Philip C. Borgman, Matthew A. Blackbourne, Lorne H. Perkins, Jeremy G. TI Timing and location of blood product transfusion and outcomes in massively transfused combat casualties SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY LA English DT Article DE Apheresis platelets; resuscitation; massive transfusion; combat trauma ID LIFE-THREATENING COAGULOPATHY; TRAUMA PATIENT HYPOTHERMIA; IMPROVED SURVIVAL; DAMAGE CONTROL; PLATELET; RATIO; MORTALITY; IMPACT; RESUSCITATION; PLASMA AB BACKGROUND: Hemostatic resuscitation using blood components in a 1: 1:1 ratio of platelets: fresh frozen plasma: red blood cells (RBCs) is based on analyses of massive transfusion (MT, >= Q10 RBC units in 24 hours). These 24-hour analyses are weakened by survival bias and do not describe the timing and location of transfusions. Mortality outcomes associated with early (first 6 hours) resuscitation incorporating platelets, for combat casualties requiring MT, have not been reported. METHODS: We analyzed records for 8,618 casualties treated at the United States military hospital in Baghdad, Iraq, between January 2004 and December 2006. Patients (n = 414) requiring MT, not receiving fresh whole blood, and surviving at least 1 hour (reducing survival bias) were divided into 6-hour apheresis platelet (aPLT) transfusion ratio groups: LOW (aPLT: RBC, <= 0.1, n = 344) and HIGH (aPLT: RBC, >0.1, n = 70). Baseline characteristics of groups were compared. Factors influencing survival on univariate analysis were included in Cox proportional hazards models of 24-hour and 30-day survival. RESULTS: Patients received aPLT in the emergency department (4%), operating room (45%), intensive care unit (51%). The HIGH group presented with higher (p < 0.05) admission International Normalized Ratio (1.6 vs. 1.4), base deficit (8 vs. 7), and temperature (36.7 vs. 36.4). Overall mortality was 27%. At 24 hours, the HIGH group showed lower mortality (10.0% vs. 22.1%, p = 0.02). Absolute differences in 30-day mortality were not significant (HIGH, 18.6%; LOW, 28.8%, p = 0.08). On adjusted analysis, the HIGH group was independently associated with increased survival: LOW group mortality hazard ratios were 4.1 at 24 hours and 2.3 at 30 days compared with HIGH group (p = 0.03 for both). Increasing 6-hour FFP:RBC ratio was also independently associated with increased survival. CONCLUSION: Early (first 6 hours) hemostatic resuscitation incorporating platelets and plasma is associated with improved 24-hour and 30-day survival in combat casualties requiring MT. (J Trauma Acute Care Surg. 2012; 73: S89-S94. Copyright (C) 2012 by Lippincott Williams & Wilkins) C1 [Cap, Andrew P.; Spinella, Philip C.; Blackbourne, Lorne H.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Spinella, Philip C.] Washington Univ, St Louis, MO USA. [Borgman, Matthew A.] San Antonio Mil Med Ctr, Ft Sam Houston, TX USA. [Perkins, Jeremy G.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. RP Cap, AP (reprint author), USA, Inst Surg Res, 3698 Chambers Pass,Bldg 3610, Ft Sam Houston, TX 78234 USA. EM andre.p.cap@us.army.mil RI Borgman, Matthew/L-9477-2015 OI Borgman, Matthew/0000-0002-2008-7380 NR 30 TC 28 Z9 28 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 2163-0755 J9 J TRAUMA ACUTE CARE JI J. Trauma Acute Care Surg. PD AUG PY 2012 VL 73 SU 1 BP S89 EP S94 DI 10.1097/TA.0b013e318260625a PG 6 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 992VP UT WOS:000307808500016 PM 22847102 ER PT J AU Convertino, VA Parquette, B Zeihr, J Traynor, K Baia, D Baumblatt, M Vartanian, L Suresh, M Metzger, A Gerhardt, RT Lurie, KG Lindstrom, D AF Convertino, Victor A. Parquette, Brent Zeihr, John Traynor, Kevin Baia, Daryn Baumblatt, Mark Vartanian, Levon Suresh, Mithun Metzger, Anja Gerhardt, Robert T. Lurie, Keith G. Lindstrom, David TI Use of respiratory impedance in prehospital care of hypotensive patients associated with hemorrhage and trauma: A case series SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY LA English DT Article DE Impedance threshold device; hypotension; lower body negative pressure ID CEREBRAL-BLOOD-FLOW; INSPIRATORY RESISTANCE; THRESHOLD DEVICE; CENTRAL HYPOVOLEMIA; HEMODYNAMIC-RESPONSES; PRESSURE; SYMPTOMS; HUMANS; PIGS AB BACKGROUND: The respiratory pump can be optimized to enhance circulation in patients with hypotension by having patients spontaneously breathe through a low level of inspiratory resistance. This can be achieved with an impedance threshold device (ITD) designed to provide 7 cm H2O resistance during spontaneous inspiration with minimal resistance during expiration. Little is known about the effects of harnessing this physiological concept to increase blood pressure (BP) in the prehospital setting of care for patients with hypotension caused by blood loss or trauma. In this case series, we report on the feasibility, effectiveness, and safety of rapidly deploying the ITD by first responders to treat hypotension secondary to blood loss and trauma in the urban setting by emergency medical services personnel. METHODS: Hemodynamic data from hypotensive patients (pretreatment systolic BP [SBP] <100 mm Hg) from 3 U.S. cities where the ITD is deployed were evaluated. The primary end point was maximum change in SBP and diastolic BP (DBP) from before to during ITD use in patients with hypotension secondary to documented blood loss or trauma. Secondary end points were device tolerance, whether the patient felt "better,'' change in heart rate, O-2 saturation, and adverse events. RESULTS: Of the 255 hypotensive patients treated, there were 26 categorized with blood loss and 13 with trauma. In this 39-patient subgroup, the SBP and DBP (mean +/- SD) increased from 79 +/- 14 mm Hg and 48 +/- 12 mm Hg before ITD placement to 110 +/- 17 mm Hg and 66 +/- 14 mm Hg after ITD placement (p < 0.001). Breathing through the ITD resulted in no reported adverse events, was well tolerated, and resulted in feeling "better'' in more than 85% of the patients. CONCLUSION: Use of an ITD by emergency medical services personnel on hypotensive spontaneously breathing patients secondary to blood loss and trauma increased SBP and DBP and was feasible, well tolerated, and not associated with adverse effects (e.g., increased bleeding). (J Trauma Acute Care Surg. 2012;73: S54-S59. Copyright (c) 2012 by Lippincott Williams & Wilkins) C1 [Convertino, Victor A.; Suresh, Mithun; Gerhardt, Robert T.] USA, Inst Surg Res, Tact Combat Casualty Care Res Program, Ft Sam Houston, TX 78234 USA. [Parquette, Brent; Zeihr, John; Lindstrom, David] Lucas Cty Emergency Med Serv, Toledo, OH USA. [Traynor, Kevin; Vartanian, Levon] Cypress Creek Emergency Med Serv, Spring, TX USA. [Baia, Daryn] Empress Emergency Med Serv, Yonkers, NY USA. [Baumblatt, Mark] Eastchester Emergency Med Serv, Eastchester, NY USA. [Metzger, Anja; Lurie, Keith G.] Univ Minnesota, Med Ctr, Dept Emergency Med, Minneapolis, MN 55455 USA. [Metzger, Anja; Lurie, Keith G.] Adv Circulatory Syst Inc, Roseville, NSW, Australia. [Lurie, Keith G.] Minnesota Med Res Fdn, Minneapolis, MN USA. RP Convertino, VA (reprint author), USA, Inst Surg Res, Tact Combat Casualty Care Res Program, 3698 Chambers Pass, Ft Sam Houston, TX 78234 USA. EM victor.convertino@amedd.army.mil FU United States Army Medical Research and Materiel Command Combat Casualty Research Program; Small Business Innovative Research Program FX The authors declare no conflicts of interest. This research was supported in part by funding from the United States Army Medical Research and Materiel Command Combat Casualty Research Program and the Small Business Innovative Research Program. Drs. Lurie and Metzger have disclosed a relationship with Advanced Circulatory Systems. NR 15 TC 6 Z9 6 U1 0 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 2163-0755 J9 J TRAUMA ACUTE CARE JI J. Trauma Acute Care Surg. PD AUG PY 2012 VL 73 SU 1 BP S54 EP S59 DI 10.1097/TA.0b013e3182606124 PG 6 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 992VP UT WOS:000307808500010 PM 22847095 ER PT J AU Deng-Bryant, Y Chen, ZY van der Merwe, C Liao, ZL Dave, JR Rupp, R Shear, DA Tortella, FC AF Deng-Bryant, Ying Chen, Zhiyong van der Merwe, Christopher Liao, Zhilin Dave, Jitendra R. Rupp, Randall Shear, Deborah A. Tortella, Frank C. TI Long-term administration of amnion-derived cellular cytokine suspension promotes functional recovery in a model of penetrating ballistic-like brain injury SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY LA English DT Article; Proceedings Paper CT Advanced Technology Applications for Combat Casualty Care Conference (ATACCC) CY AUG 15-18, 2011 CL Ft Lauderdale, FL DE Penetrating ballistic-like brain injury; amnion-derived cellular cytokine suspension; rotarod; silver stain; glial fibrillary acidic protein ID EPITHELIAL-CELLS; HEAD-INJURY; TRANSPLANTATION; SURVIVAL; MOTOR AB BACKGROUND: Previous work has shown that human amnion-derived progenitor (AMP) cell therapy is neuroprotective in a penetrating ballistic-like brain injury (PBBI) model. However, the neuroprotective capacity of AMP cells seemed to be mediated by the sustained secretion of AMP cell-derived neurotrophic factors, which are abundant in the amnion-derived cellular cytokine suspension (ACCS). To test this theory, the current study assessed the neuroprotective efficacy of long-term ACCS delivery in the PBBI model. METHODS: Experiment 1 assessed the bioactive stability and neuroprotective capacity of ACCS in an in vitro model of neurodegeneration. Experiment 2 evaluated the therapeutic effects of ACCS delivery initiated 15 minutes after PBBI and continued for 2 weeks after injury. Experiment 3 was designed to identify the therapeutic window for long-term ACCS delivery in the PBBI model. Outcome metrics included neurobehavioral assessments and neuropathologic measures of neuroinflammation and axonal/neuronal degeneration. RESULTS: Experiment 1 demonstrated that ACCS is thermally stable for 1 week at 37 degrees C and that ACCS treatment protected neurite against staurosporine toxicity. Experiment 2 identified the optimal infusion rate of ACCS (1 mu L/h) and demonstrated that long-term infusion of ACCS was capable of promoting significant protection against PBBI-induced neuropathology and motor abnormalities, but was not sufficient for reducing cognitive deficits. Finally, the results of Experiment 3 showed that ACCS is effective in promoting significant neuroprotection even when onset of treatment is delayed out to 24 hours (but not 48 hours) after PBBI. CONCLUSIONS: Collectively, our results support the hypothesis that the neuroprotective effects of AMP cells are mediated through a sustained delivery of ACCS, which implicates ACCS as a promising neuroprotection agent for clinical study. (J Trauma Acute Care Surg. 2012; 73: S156-S164. Copyright (C) 2012 by Lippincott Williams & Wilkins) C1 [Deng-Bryant, Ying; Chen, Zhiyong; van der Merwe, Christopher; Liao, Zhilin; Dave, Jitendra R.; Shear, Deborah A.; Tortella, Frank C.] Walter Reed Army Inst Res, Brain Trauma Neuroprotect & Neurorestorat Branch, Ctr Mil Psychiat & Neurosci, Silver Spring, MD 20910 USA. [Rupp, Randall] Stemnion Inc, Pittsburgh, PA USA. RP Deng-Bryant, Y (reprint author), Walter Reed Army Inst Res, Brain Trauma Neuroprotect & Neurorestorat Branch, Ctr Mil Psychiat & Neurosci, 503 Robert Grant Ave,Room 2W15, Silver Spring, MD 20910 USA. EM ying.d.bryant@us.army.mil RI Shear, Deborah/B-3607-2011; Dave, Jitendra/A-8940-2011 NR 27 TC 3 Z9 3 U1 0 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 2163-0755 J9 J TRAUMA ACUTE CARE JI J. Trauma Acute Care Surg. PD AUG PY 2012 VL 73 SU 1 BP S156 EP S164 DI 10.1097/TA.0b013e3182625f5f PG 9 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 992VP UT WOS:000307808500027 PM 22847087 ER PT J AU Lairet, JR Bebarta, VS Burns, CJ Lairet, KF Rasmussen, TE Renz, EM King, BT Fernandez, W Gerhardt, R Butler, F DuBose, J Cestero, R Salinas, J Torres, P Minnick, J Blackbourne, LH AF Lairet, Julio R. Bebarta, Vikhyat S. Burns, Christopher J. Lairet, Kimberly F. Rasmussen, Todd E. Renz, Evan M. King, Booker T. Fernandez, William Gerhardt, Robert Butler, Frank DuBose, Joseph Cestero, Ramon Salinas, Jose Torres, Pedro Minnick, Joanne Blackbourne, Lorne H. TI Prehospital interventions performed in a combat zone: A prospective multicenter study of 1,003 combat wounded SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY LA English DT Article DE Lifesaving intervention; prehospital; resuscitation; tactical combat casualty care; emergency medical services ID CASUALTY CARE; DEATH; RESUSCITATION; MANAGEMENT; PROGRAM; INJURY; TRAUMA AB BACKGROUND: Battlefield care given to a casualty before hospital arrival impacts clinical outcomes. To date, the published data regarding care given in the prehospital setting of a combat zone are limited. The purpose of this study was to describe the incidence and efficacy of specific prehospital lifesaving interventions (LSIs; interventions that could affect the outcome of the casualty), consistent with the Tactical Combat Casualty Care paradigm, performed during the resuscitation of casualties in a combat zone. METHODS: We performed a prospective observational study between November 2009 and November 2011. Casualties were enrolled as they were treated at six US surgical facilities in Afghanistan. Descriptive data were collected on a standardized data collection form and included mechanism of injury, airway management, chest and hemorrhage interventions, vascular access, type of fluid administered, and hypothermia prevention. On arrival to the military hospital, the treating physician determined whether an intervention was performed correctly and whether an intervention was not performed that should have been performed (missed LSI). RESULTS: A total of 1,003 patients met the inclusion criteria. Their mean (SD) age was 25 (8.5) years and 97% were male. The mechanism of injury was explosion in 60% of patients, penetrating in 24% of patients, blunt in 15% of patients, and burn in 0.8% of patients. The most commonly performed LSIs included hemorrhage control (n = 599), hypothermia prevention (n = 429), and vascular access (n = 388). Of the missed LSIs, 252 were identified with the highest percentage of missed opportunities being composed of endotracheal intubation, chest needle decompression, and hypotensive resuscitation. In contrast, tourniquet application had the lowest percentage of missed opportunities. CONCLUSIONS: In our prospective study of prehospital LSIs performed in a combat zone, we observed a higher rate of incorrectly performed and missed LSIs in airway and chest (breathing) interventions than hemorrhage control interventions. The most commonly performed LSIs had lower incorrect and missed LSI rates. (J Trauma Acute Care Surg. 2012;73: S38-S42. Copyright (c) 2012 by Lippincott Williams & Wilkins) C1 [Lairet, Julio R.; Bebarta, Vikhyat S.] San Antonio Mil Med Ctr, Dept Emergency Med, San Antonio, TX USA. [Burns, Christopher J.; Cestero, Ramon] Naval Med Res Unit San Antonio, Navy Combat Casualty Care, San Antonio, TX USA. [Lairet, Kimberly F.; Rasmussen, Todd E.; Renz, Evan M.; King, Booker T.; Gerhardt, Robert; Salinas, Jose; Blackbourne, Lorne H.] USA, Inst Surg Res, Houston, TX USA. [Fernandez, William] Boston Med Ctr, Boston, MA USA. [Butler, Frank] Tact Combat Casualty Care Program, San Antonio, TX USA. [DuBose, Joseph] Univ Maryland Med Syst, AF C STARS, R Adams Cowley Shock Trauma Ctr, Baltimore, MD USA. [Lairet, Julio R.; Torres, Pedro; Minnick, Joanne] Enroute Care Res Ctr, Houston, TX USA. RP Lairet, JR (reprint author), San Antonio Mil Med Ctr, Dept Emergency Med, San Antonio, TX USA. EM JRLairet@pol.net RI bebarta, vikhyat/K-3476-2015 OI Fernandez, William/0000-0003-1723-2273; NR 16 TC 27 Z9 28 U1 0 U2 6 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 2163-0755 J9 J TRAUMA ACUTE CARE JI J. Trauma Acute Care Surg. PD AUG PY 2012 VL 73 SU 1 BP S38 EP S42 DI 10.1097/TA.0b013e3182606022 PG 5 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 992VP UT WOS:000307808500007 PM 22847092 ER PT J AU Mabry, RL Apodaca, A Penrod, J Orman, JA Gerhardt, RT Dorlac, WC AF Mabry, Robert L. Apodaca, Amy Penrod, Jason Orman, Jean A. Gerhardt, Robert T. Dorlac, Warren C. TI Impact of critical care-trained flight paramedics on casualty survival during helicopter evacuation in the current war in Afghanistan SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY LA English DT Article; Proceedings Paper CT Advanced Technology Applications for Combat Casualty Care Conference (ATACCC) CY AUG 15-18, 2011 CL Ft Lauderdale, FL DE Helicopter; military; trauma; flight medic; Afghanistan; emergency medical services ID TRAUMATIC BRAIN-INJURY; EMERGENCY CARE; SERVICES; TRANSPORT; MORTALITY; INTUBATION; OUTCOMES; VICTIMS; PATIENT; ILL AB BACKGROUND: The US Army pioneered medical evacuation (MEDEVAC) by helicopter, yet its system remains essentially unchanged since the Vietnam era. Care is provided by a single combat medic credentialed at the Emergency Medical Technician - Basic level. Treatment protocols, documentation, medical direction, and quality improvement processes are not standardized and vary significantly across US Army helicopter evacuation units. This is in contrast to helicopter emergency medical services that operate within the United States. Current civilian helicopter evacuation platforms are routinely staffed by critical care-trained flight paramedics (CCFP) or comparably trained flight nurses who operate under trained EMS physician medical direction using formalized protocols, standardized patient care documentation, and rigorous quality improvement processes. This study compares mortality of patients with injury from trauma between the US Army's standard helicopter evacuation system staffed with medics at the Emergency Medical Technician - Basic level (standard MEDEVAC) and one staffed with experienced CCFP using adopted civilian helicopter emergency medical services practices. METHODS: This is a retrospective study of a natural experiment. Using data from the Joint Theater Trauma Registry, 48-hour mortality for severely injured patients (injury severity score >= 16) was compared between patients transported by standard MEDEVAC units and CCFP air ambulance units. RESULTS: The 48-hour mortality for the CCFP-treated patients was 8% compared to 15% for the standard MEDEVAC patients. After adjustment for covariates, the CCFP system was associated with a 66% lower estimated risk of 48-hour mortality compared to the standard MEDEVAC system. CONCLUSIONS: These findings demonstrate that using an air ambulance system based on modern civilian helicopter EMS practice was associated with a lower estimated risk of 48-hour mortality among severely injured patients in a combat setting. (J Trauma Acute Care Surg. 2012;73: S32-S37. Copyright (c) 2012 by Lippincott Williams & Wilkins) LEVEL OF EVIDENCE: Therapeutic study, level II. C1 [Mabry, Robert L.] USA, Inst Surg Res, MCMR SRJ, San Antonio, TX 78234 USA. RP Mabry, RL (reprint author), USA, Inst Surg Res, MCMR SRJ, 3400 Rawley E Chambers Ave, San Antonio, TX 78234 USA. EM robert.mabry@us.army.mil NR 36 TC 25 Z9 25 U1 4 U2 11 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 2163-0755 J9 J TRAUMA ACUTE CARE JI J. Trauma Acute Care Surg. PD AUG PY 2012 VL 73 SU 1 BP S32 EP S37 DI 10.1097/TA.0b013e3182606001 PG 6 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 992VP UT WOS:000307808500006 PM 22847091 ER PT J AU Mitrophanov, AY Rosendaal, FR Reifman, J AF Mitrophanov, Alexander Y. Rosendaal, Frits R. Reifman, Jaques TI Therapeutic correction of thrombin generation in dilution-induced coagulopathy: Computational analysis based on a data set of healthy subjects SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY LA English DT Article; Proceedings Paper CT Advanced Technology Applications for Combat Casualty Care Conference (ATACCC) CY AUG 15-18, 2011 CL Ft Lauderdale, FL DE Prothrombin complex concentrates; coagulation factors; factor VIIa; thrombin; antithrombin ID PROTHROMBIN COMPLEX CONCENTRATE; VITRO THROMBELASTOGRAPHY MEASUREMENTS; VIVO BLEEDING-TIME; FACTOR VIIA; BLOOD-COAGULATION; HYPOTHERMIC COAGULOPATHY; TRAUMA; MODEL; MANAGEMENT; TRANSFUSION AB BACKGROUND: Prothrombin complex concentrates (PCCs), which contain different coagulation proteins, are attractive alternatives to the standard methods to treat dilution-induced (and, generally, traumatic) coagulopathy. We investigated the ability of a novel PCC composition to restore normal thrombin generation in diluted blood. The performance of the proposed PCC composition (coagulation factors [F] II, IX, and X and the anticoagulant antithrombin), designated PCC-AT, was compared with that of FVIIa and PCC-FVII, which is the PCC composition containing FII, FVII, FIX, and FX (main components of most PCCs). METHODS: We used a thoroughly validated computational model to simulate thrombin generation in normal and diluted blood for 472 healthy subjects in the control group of the Leiden Thrombophilia Study. For every simulated thrombin curve, we calculated and analyzed five standard thrombin generation parameters. RESULTS: The three therapeutic agents (FVIIa, PCC-FVII, and PCC-AT) caused statistically significant changes in each of the five thrombin generation parameters in diluted blood. Factor VIIa tended to primarily impact clotting time, thrombin peak time, and maximum slope of the thrombin curve, whereas in the case of PCC-FVII, thrombin peak height and the area under the thrombin curve were affected particularly strongly. As a result, these two therapeutics tended to push those respective parameters outside their normal ranges. PCC-AT significantly outperformed both FVIIa and PCC-FVII in its ability to normalize individual thrombin generation parameters in diluted blood. Furthermore, PCC-AT could simultaneously restore all five thrombin generation parameters to their normal levels in every subject in the study group. CONCLUSIONS: Our computational results suggest that PCC-AT may demonstrate a superior ability to restore normal thrombin generation compared with FVIIa and PCC-FVII. (J Trauma Acute Care Surg. 2012; 73: S95-S102. Copyright (C) 2012 by Lippincott Williams & Wilkins) C1 [Mitrophanov, Alexander Y.; Reifman, Jaques] USA, Med Res & Mat Command, DoD Biotechnol High Performance Comp Software App, Telemed & Adv Technol Res Ctr, Ft Detrick, MD 21702 USA. [Rosendaal, Frits R.] Leiden Univ, Med Ctr, Dept Clin Epidemiol & Hemostasis, Leiden, Netherlands. [Rosendaal, Frits R.] Leiden Univ, Med Ctr, Thrombosis Res Ctr, Leiden, Netherlands. RP Mitrophanov, AY (reprint author), USA, Med Res & Mat Command, DoD Biotechnol High Performance Comp Software App, Telemed & Adv Technol Res Ctr, ATTN MCMR TT,504 Scott St, Ft Detrick, MD 21702 USA. EM alex@bhsai.org; jaques.reifman@us.army.mil NR 31 TC 13 Z9 13 U1 0 U2 4 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 2163-0755 J9 J TRAUMA ACUTE CARE JI J. Trauma Acute Care Surg. PD AUG PY 2012 VL 73 SU 1 BP S95 EP S102 DI 10.1097/TA.0b013e3182609bca PG 8 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 992VP UT WOS:000307808500017 PM 22847103 ER PT J AU Newkirk, M Pamplin, JC Kuwamoto, R Allen, DA Chung, KK AF Newkirk, Michelle Pamplin, Jeremy C. Kuwamoto, Roderick Allen, David A. Chung, Kevin K. TI Checklists change communication about key elements of patient care SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY LA English DT Article DE Checklist; intensive care; communication ID BLOOD-STREAM INFECTIONS; INTENSIVE-CARE; DAILY GOALS; UNIT; QUALITY; SAFETY; IMPROVEMENT; HANDOVER; ICU AB BACKGROUND: Combat casualty care is distributed across professions and echelons of care. Communication within it is fragmented, inconsistent, and prone to failure. Daily checklists used during intensive care unit (ICU) rounds have been shown to improve compliance with evidence-based practices, enhance communication, promote consistency of care, and improve outcomes. Checklists are criticized because it is difficult to establish a causal link between them and their effect on outcomes. We investigated how checklists used during ICU rounds affect communication. METHODS: We conducted this project in two military ICUs (burn and surgical/trauma). Checklists contained up to 21 questions grouped according to patient population. We recorded which checklist items were discussed during rounds before and after implementation of a "must address" checklist and compared the frequency of discussing items before checklist prompting. RESULTS: Patient discussions addressed more checklist items before prompting at the end of the 2-week evaluation compared with the 2-week preimplementation period (surgical trauma ICU, 36% vs. 77%, p < 0.0001; burn ICU, 47% vs. 72 %, p < 0.001). Most items were addressed more frequently in both ICUs after implementation. Key items such as central line removal, reduction of laboratory testing, medication reconciliation, medication interactions, bowel movements, sedation holidays, breathing trials, and lung protective ventilation showed significant improvements. CONCLUSION: Checklists modify communication patterns. Improved communication facilitated by checklists may be one mechanism behind their effectiveness. Checklists are powerful tools that can rapidly alter patient care delivery. Implementing checklists could facilitate the rapid dissemination of clinical practice changes, improve communication between echelons of care and between individuals involved in patient care, and reduce missed information. (J Trauma Acute Care Surg. 2012;73: S75-S82. Copyright (C) 2012 by Lippincott Williams & Wilkins) C1 [Newkirk, Michelle] San Antonio Mil Med Ctr, Dept Med, Ft Sam Houston, TX USA. [Pamplin, Jeremy C.; Kuwamoto, Roderick] San Antonio Mil Med Ctr, Dept Surg, Ft Sam Houston, TX USA. [Allen, David A.; Chung, Kevin K.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Pamplin, JC (reprint author), Brooke Army Med Ctr, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM Jeremy.pamplin@us.army.mil NR 26 TC 17 Z9 17 U1 1 U2 11 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 2163-0755 J9 J TRAUMA ACUTE CARE JI J. Trauma Acute Care Surg. PD AUG PY 2012 VL 73 SU 1 BP S75 EP S82 DI 10.1097/TA.0b013e3182606239 PG 8 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 992VP UT WOS:000307808500014 PM 22847100 ER PT J AU Patel, S Rasmussen, TE Gifford, SM Apodaca, AN Eastridge, BJ Blackbourne, LH AF Patel, Shimul Rasmussen, Todd E. Gifford, Shaun M. Apodaca, Amy N. Eastridge, Brian J. Blackbourne, Lorne H. TI Interpreting comparative died of wounds rates as a quality benchmark of combat casualty care SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY LA English DT Article; Proceedings Paper CT Advanced Technology Applications for Combat Casualty Care Conference (ATACCC) CY AUG 15-18, 2011 CL Ft Lauderdale, FL DE Wartime injury; lethality of battlefield; military trauma ID OPERATION-ENDURING-FREEDOM; IRAQI-FREEDOM; TRAUMA; INJURY; DEATH; WAR AB BACKGROUND: The died of wounds (DOW) rate is cited as a measure of combat casualty care effectiveness without the context of injury severity or insight into lethality of the battlefield. The objective of this study was to characterize injury severity and other factors related to variations in the DOW rate. METHODS: The highest monthly DOW (HDOW) and lowest monthly DOW (LDOW) rates from 2004 to 2008 were identified from analysis and casualty report databases and used to direct a search of the Joint Theater Trauma Registry. Casualties from the HDOW and LDOW were combined into cohorts, and injury data were analyzed and compared. RESULTS: The HDOW rates were 13.4%, 11.6%, and 12.8% (mean, 12.6%), and the LDOW rates were 1.3%, 2.0%, and 2.7% (mean, 2.0%) (p < 0.0001). The HDOW (n = 541) and LDOW (n = 349) groups sustained a total of 1,154 wounds. Injury Severity Score was greater in the HDOW than the LDOWgroup (mean [SD], 11.1 [0.53] vs. 9.4 [0.58]; p = 0.03) as was the percentage of patients with Injury Severity Score of more than 25 (HDOW, 12% vs. LDOW, 7.7%; p = 0.04). Excluding minor injuries (Abbreviated Injury Scale score of 1), there was a greater percentage of chest injuries in the HDOW compared with the LDOW group (16.5% vs. 11.2%, p = 0.03). Explosive mechanisms were more commonly the cause of injury in the HDOW group (58.7% vs. 49.7%; p = 0.007), which also had a higher percentage of Marine Corps personnel (p = 0.02). CONCLUSION: This study provides novel data demonstrating that the died of wounds rate ranges significantly throughout the course of combat. Discernible differences in injury severity, wounding patterns, and even service affiliation exist within this variation. For accuracy, the died of wounds rate should be cited only in the context of associated injury patterns, injury severity, and mechanisms of injury. Without this context, DOW should not be used as a comparative medical metric. (J Trauma Acute Care Surg. 2012;73: 60-63. Copyright (C) 2012 by Lippincott Williams & Wilkins) C1 [Patel, Shimul; Rasmussen, Todd E.; Gifford, Shaun M.; Apodaca, Amy N.; Eastridge, Brian J.; Blackbourne, Lorne H.] USA, Inst Surg Res, Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. RP Rasmussen, TE (reprint author), US Inst Surg Res, Ft Sam Houston, TX USA. EM todd.rasmussen@amedd.army.mil NR 15 TC 5 Z9 5 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 2163-0755 J9 J TRAUMA ACUTE CARE JI J. Trauma Acute Care Surg. PD AUG PY 2012 VL 73 SU 1 BP S60 EP S63 DI 10.1097/TA.0b013e31826061b4 PG 4 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 992VP UT WOS:000307808500011 PM 22847096 ER PT J AU Patzkowski, JC Owens, JG Blanck, RV Kirk, KL Hsu, JR AF Patzkowski, Jeanne C. Owens, Johnny G. Blanck, Ryan V. Kirk, Kevin L. Hsu, Joseph R. CA Skeletal Trauma Res Consortium STR TI Deployment after limb salvage for high-energy lower-extremity trauma SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY LA English DT Article; Proceedings Paper CT Advanced Technology Applications for Combat Casualty Care Conference (ATACCC) CY AUG 15-18, 2011 CL Ft Lauderdale, FL DE Limb salvage; high-energy lower-extremity trauma; energy storing ankle foot orthosis; high-intensity progression-oriented rehabilitation ID PATIENT; COMBAT; RETURN; FOOT AB BACKGROUND: Many wounded warriors experienced high-energy lower-extremity trauma (HELET) that may be limb threatening. Volumetric muscle loss, posttraumatic osteoarthritis, nerve injuries, and pain may severely limit physical function. Several wounded warriors express a strong desire to return to their units and be deployed in their original military occupational specialty. We began the return-to-run (RTR) clinical pathway at our institution 2 years ago to facilitate high-performance goals such as these. It involves an energy storing ankle foot orthosis, the intrepid dynamic exoskeletal orthosis in combination with high-intensity, progression-oriented rehabilitation. We sought to determine the rate of deployment or predeployment training after participation in this noninvasive intervention. METHODS: A retrospective analysis of the RTR database was performed to determine the rate of deployment or predeployment training among those service members who began participation in the RTR between November of 2009 and March of 2011. Medical records were reviewed for demographics, injury, surgical data, and major complications. Requests for delayed amputation were recorded, and charts were reviewed to determine if patients eventually elected to proceed with amputation or if they chose to continue with limb salvage. RESULTS: Between November 2009 and March 2011, 87 service members completed the RTR. Of these, 17 (19.5%) have been deployed to combat or are in predeployment training. Sixteen serve in combat arms (nine Special Forces, four infantry/ranger, two combat engineers, and one gunner), and one is a member of the military intelligence community. Fifteen patients sustained their injuries as a result of HELET (four gunshot, five motor vehicle collisions, four explosions, one parachute injury, and one fall from height), one had idiopathic avascular necrosis of the talus, and one had an iatrogenic nerve injury after pelvic surgery. Six of the patients underwent circular external fixation, five received joint fusions (three ankle, two subtalar joint), and nine had major nerve injuries. Four initially desired amputation of their injured limb but have subsequently countermanded their request. CONCLUSION: Returning to high-level physical function after HELET is challenging. After implementation of the RTR clinical pathway with the intrepid dynamic exoskeletal orthosis, 19.5% of wounded warriors treated with the RTR have been deployed or will be deployed in the coming year. (J Trauma Acute Care Surg. 2012; 73: S112-S115. Copyright (C) 2012 by Lippincott Williams & Wilkins) C1 [Patzkowski, Jeanne C.; Kirk, Kevin L.; Hsu, Joseph R.] San Antonio Mil Med Ctr, Ft Sam Houston, TX 78234 USA. [Owens, Johnny G.; Blanck, Ryan V.] Ctr Intrepid, Ft Sam Houston, TX USA. [Hsu, Joseph R.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Patzkowski, JC (reprint author), San Antonio Mil Med Ctr, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM Jeanne.patzkowski@us.army.mil NR 11 TC 10 Z9 10 U1 1 U2 8 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 2163-0755 J9 J TRAUMA ACUTE CARE JI J. Trauma Acute Care Surg. PD AUG PY 2012 VL 73 SU 1 BP S112 EP S115 DI 10.1097/TA.0b013e3182606291 PG 4 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 992VP UT WOS:000307808500020 PM 22847079 ER PT J AU Rapp, PE Curley, KC AF Rapp, Paul E. Curley, Kenneth C. TI Is a diagnosis of "mild traumatic brain injury" a category mistake? SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY LA English DT Article; Proceedings Paper CT Advanced Technology Applications for Combat Casualty Care Conference (ATACCC) CY AUG 15-18, 2011 CL Fort Lauderdale, FL DE Diagnosis; mild TBI; nosology ID CLOSED-HEAD-INJURY; POSTTRAUMATIC-STRESS-DISORDER; TEST-RETEST RELIABILITY; POST-CONCUSSION SYMPTOMS; CLINICAL NEUROPHYSIOLOGY SOCIETY; EYE-TARGET SYNCHRONIZATION; EVENT-RELATED POTENTIALS; COMPLAINT BASE RATES; QUANTITATIVE EEG; AMERICAN ACADEMY AB BACKGROUND: Efforts to produce definitions and diagnostic standards for mild traumatic brain injury (TBI) have a long and complex history. The diagnosis of TBI must be considered in the larger context of neuropsychiatric diagnosis. A major reconceptualization of diagnosis is now underway in which the classical syndrome conceptualization is being discarded. We address the question, what are the implications of this revision of thinking in the specific context of TBI? METHODS: A recent literature on logical structures for neuropsychiatric disorders was reviewed. The symptom pattern of TBI was identified, and a literature survey determined the frequency of these symptom patterns in other disorders and in healthy control populations. RESULTS: The frequency of symptom endorsement in populations without a history of TBI can be equal to endorsement frequencies in populations with a history of mild TBI. In some studies, the frequency of symptom endorsement in healthy controls having no history of head injury actually exceeded the endorsement rates in a comparison group with a history mild TBI. CONCLUSION: The heterogeneity of this clinical population and their clinical presentations, the absence of a unitary etiology of postinjury deficits, and the complex idiosyncratic time course of the appearance of these deficits argue against the valid implementation of the classical model of diagnosis. In addition, the accepted criteria of diagnostic utility are not satisfied. TBI is not a disease; it is an event. More precisely, TBI is an event or a sequence of events that can, in some instances, lead to a diagnosable neurological or psychiatric disorder. (J Trauma Acute Care Surg. 2012;73:S13-S23. Copyright (c) 2012 by Lippincott Williams & Wilkins) C1 [Rapp, Paul E.] Uniformed Serv Univ Hlth Sci, Dept Mil & Emergency Med, Traumat Injury Res Program, Bethesda, MD 20814 USA. [Curley, Kenneth C.] USA, Med Res & Mat Command, Combat Casualty Care Directorate, Ft Detrick, MD USA. RP Rapp, PE (reprint author), Uniformed Serv Univ Hlth Sci, Dept Mil & Emergency Med, Traumat Injury Res Program, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA. EM prapp@usuhs.mil NR 119 TC 9 Z9 9 U1 5 U2 20 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 2163-0755 EI 2163-0763 J9 J TRAUMA ACUTE CARE JI J. Trauma Acute Care Surg. PD AUG PY 2012 VL 73 SU 1 BP S13 EP S23 DI 10.1097/TA.0b013e318260604b PG 11 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 992VP UT WOS:000307808500004 PM 22847083 ER PT J AU Ryan, KL Blackbourne, LH Cancio, LC Dunn, WJ Jordan, BS McClinton, AR Nelson, BS Rathbone, CR Ross, JD Kragh, JF AF Ryan, Kathy L. Blackbourne, Lorne H. Cancio, Leopoldo C. Dunn, William J. Jordan, Bryan S. McClinton, Annette R. Nelson, Betty S. Rathbone, Christopher R. Ross, James D. Kragh, John F. TI The Battlefield Health and Trauma Research Institute Scientific Ethics Committee: An evolving model for fostering a culture of integrity SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY LA English DT Review DE Responsible conduct of research; ethics ID RESEARCH MISCONDUCT; RETRACTION AB "The scientific enterprise is built on a foundation of trust. Society trusts that scientific research results are an honest and accurate reflection of a researcher's work. Researchers equally trust that their colleagues have gathered data carefully, have used appropriate analytic and statistical techniques, have reported their results accurately, and have treated the work of other researchers with respect. When this trust is misplaced and the professional standards of science are violated, researchers are not just personally affronted-they feel that the base of their profession has been undermined. This would impact the relationship between science and society." C1 [Ryan, Kathy L.; Blackbourne, Lorne H.; Cancio, Leopoldo C.; Jordan, Bryan S.; McClinton, Annette R.; Nelson, Betty S.; Rathbone, Christopher R.; Kragh, John F.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Dunn, William J.] USAF, Sch Aerosp Med, Detachment 1, Ft Sam Houston, TX USA. [Ross, James D.] USN, Med Res Unit San Antonio, Ft Sam Houston, TX USA. RP Ryan, KL (reprint author), USA, Inst Surg Res, 3698 Chambers Pass, Ft Sam Houston, TX 78234 USA. EM Kathy.l.ryan@us.army.mil FU US Army Medical and Materiel Command, Combat Casualty Care Research Program FX Funding was provided by the US Army Medical and Materiel Command, Combat Casualty Care Research Program. K.L.G. is a military service member (or employee of the US Government). This work was prepared as part of her official duties. Title 17 United States Code Section 105 provides that "Copyright protection under this title is not available for any work of the United States Government." Title 17 United States Code Section 101 defines a US Government work as a work prepared by a military service member or employee of the US Government as part of that person's official duties. The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the Departments of the Army, Air Force or Navy, or the Department of Defense. NR 16 TC 0 Z9 0 U1 1 U2 5 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 2163-0755 J9 J TRAUMA ACUTE CARE JI J. Trauma Acute Care Surg. PD AUG PY 2012 VL 73 SU 1 BP S3 EP S6 DI 10.1097/TA.0b013e3182605f9e PG 4 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 992VP UT WOS:000307808500002 PM 22847090 ER PT J AU Soller, BR Zou, FM Ryan, KL Rickards, CA Ward, K Convertino, VA AF Soller, Babs R. Zou, Fengmei Ryan, Kathy L. Rickards, Caroline A. Ward, Kevin Convertino, Victor A. TI Lightweight noninvasive trauma monitor for early indication of central hypovolemia and tissue acidosis: A review SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY LA English DT Article DE Lower body negative pressure; shock; medical monitoring; vasoconstriction ID NEAR-INFRARED SPECTROSCOPY; BODY NEGATIVE-PRESSURE; HEMORRHAGIC-SHOCK; OXYGEN-SATURATION; HEART-RATE; HUMANS; MUSCLE; PH; EPIDEMIOLOGY; MODEL AB BACKGROUND: Hemorrhage is a major cause of soldier death; it must be quickly identified and appropriately treated. We developed a prototype patient monitor that noninvasively and continuously determines muscle oxygen saturation (SmO2), muscle pH (pH(m)), and a regional assessment of blood volume (HbT) using near-infrared spectroscopy. Previous demonstration in a model of progressive, central hypovolemia induced by lower body negative pressure (LBNP) showed that SmO2 provided an early indication of impending hemodynamic instability in humans. In this review, we expand the number of subjects and provide an overview of the relationship between the muscle and sublingual microcirculation in this model of compensated shock. METHODS: Healthy human volunteers (n = 30) underwent progressive LBNP in 5-minute intervals. Standard vital signs, along with stroke volume (SV), total peripheral resistance, functional capillary density, SmO2, HbT, and pH(m) were measured continuously throughout the study. RESULTS AND DISCUSSION: SmO2 and SV significantly decreased during the first level of central hypovolemia (-15 mm Hg LBNP), whereas vital signs were later indicators of impending cardiovascular collapse. SmO2 declined with SV and inversely with total peripheral resistance throughout LBNP. HbT was correlated with declining functional capillary density, suggesting vasoconstriction as a cause for decreased SmO2 and subsequently decreased pH(m). CLINICAL TRANSLATION: The monitor has been miniaturized to a 58-g solid-state sensor that is currently being evaluated on patients with dengue hemorrhagic fever. Early results demonstrate significant decreases in SmO2 similar to those observed with progressive reductions in central blood volume. As such, this technology has the potential to (1) provide a monitoring capability for both nontraumatic and traumatic hemorrhage and (2) help combat medics triage casualties and monitor patients during lengthy transport from combat areas. (J Trauma Acute Care Surg. 2012; 73: S106-S111. Copyright (C) 2012 by Lippincott Williams & Wilkins) C1 [Ryan, Kathy L.; Convertino, Victor A.] USA, Inst Surg Res, Tact Combat Casualty Care Res Program, Ft Sam Houston, TX 78234 USA. [Soller, Babs R.; Zou, Fengmei] Reflectance Med Inc, Westborough, MA USA. [Rickards, Caroline A.] Univ Texas San Antonio, San Antonio, TX USA. [Ward, Kevin] Virginia Commonwealth Univ, Reanimat Engn Sci Ctr, Richmond, VA USA. RP Convertino, VA (reprint author), USA, Inst Surg Res, Tact Combat Casualty Care Res Program, 3698 Chambers Pass, Ft Sam Houston, TX 78234 USA. EM victor.convertino@amedd.army.mil FU United States Army; US Army; National Space Biomedical Research Institute under NASA [NCC 9-58] FX This research was supported by funding from the United States Army Medical Research and Materiel Command Combat Casualty Research Program, the US Army Small Business Technology Transfer Research program and the National Space Biomedical Research Institute under NASA Cooperative Agreement NCC 9-58 with grants to Dr. Soller at the University of Massachusetts Medical School and Reflectance Medical, Inc. Dr. Soller and Dr. Zou are employees of Reflectance Medical, Inc. Dr. Soller is an officer of Reflectance Medical and holds stock in the company. NR 26 TC 11 Z9 11 U1 0 U2 8 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 2163-0755 J9 J TRAUMA ACUTE CARE JI J. Trauma Acute Care Surg. PD AUG PY 2012 VL 73 SU 1 BP S106 EP S111 DI 10.1097/TA.0b013e318260a928 PG 6 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 992VP UT WOS:000307808500019 PM 22847078 ER PT J AU Stannard, A Scott, DJ Ivatury, RA Miller, DL Ames-Chase, AC Feider, LL Porras, CA Gifford, SM Rasmussen, TE AF Stannard, Adam Scott, Daniel J. Ivatury, Rebecca A. Miller, Diane L. Ames-Chase, April C. Feider, Laura L. Porras, Chantel A. Gifford, Shaun M. Rasmussen, Todd E. TI A collaborative research system for functional outcomes following wartime extremity vascular injury SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY LA English DT Article; Proceedings Paper CT Advanced Technology Applications for Combat Casualty Care Conference (ATACCC) CY AUG 15-18, 2011 CL Ft Lauderdale, FL DE Vascular; injury; limb; function; outcome; military; trauma; quality of life; SF-36; SMFA ID PENETRATING FEMOROPOPLITEAL INJURY; FUNCTION ASSESSMENT INSTRUMENT; HEALTH-STATUS; MODERN WARFARE; REGISTRY; TRAUMA; EXPERIENCE; OPERATIONS; VIETNAM; DEATH C1 [Scott, Daniel J.; Ivatury, Rebecca A.; Miller, Diane L.; Ames-Chase, April C.; Feider, Laura L.; Porras, Chantel A.; Gifford, Shaun M.; Rasmussen, Todd E.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Stannard, Adam] Royal Ctr Def Med, Acad Dept Mil Surg & Trauma, Birmingham, W Midlands, England. RP Rasmussen, TE (reprint author), USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. EM todd.rasmussen@us.af.mil NR 34 TC 5 Z9 5 U1 0 U2 4 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 2163-0755 J9 J TRAUMA ACUTE CARE JI J. Trauma Acute Care Surg. PD AUG PY 2012 VL 73 SU 1 BP S7 EP S12 DI 10.1097/TA.0b013e318260aa54 PG 6 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 992VP UT WOS:000307808500003 PM 22847098 ER PT J AU Tyler, JA Ritchie, JD Leas, ML Edwards, KD Eastridge, BE White, CE Knudson, MM Rasmussen, TE Martin, RR Blackbourne, LH AF Tyler, Joshua A. Ritchie, John D. Leas, Michelle L. Edwards, Kurt D. Eastridge, Brian E. White, Christopher E. Knudson, M. Margaret Rasmussen, Todd E. Martin, R. Russell Blackbourne, Lorne H. TI Combat readiness for the modern military surgeon: Data from a decade of combat operations SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY LA English DT Article; Proceedings Paper CT 70th Annual Meeting of the American-Association-for-the-Surgery-of-Trauma (AAST) / Clinical Congress of Acute Care Surgery CY SEP 14-17, 2011 CL Chicago, IL SP Amer Assoc Surg Trauma (AAST) DE Iraq; Afghanistan; deployment; training; survey ID IRAQI-FREEDOM; ENDURING-FREEDOM; INJURY SEVERITY; TOURNIQUET USE; SURGICAL-TEAM; GLOBAL WAR; SUPPORT; TRAUMA; EXPERIENCE; MORTALITY AB OBJECTIVE: Hundreds of general surgeons from the army, navy, and air force have been deployed during the past 10 years to support combat forces, but little data exist on their preparedness to handle the challenging injuries that they are currently encountering. Our objective was to assess operative and operational experience in theater with the goal of improving combat readiness among surgeons. METHODS: A detailed survey was sent to 246 active duty surgeons from the army, navy, and air force who have been deployed at least once in the past 10 years, requesting information on cases performed, perceptions of efficacy of predeployment training, knowledge deficits, and postdeployment emotional challenges. Survey data were kept confidential and analyzed using standard statistical methods. RESULTS: Of 246 individuals, 137 (56%) responded and 93 (68%) have been deployed two or more times. More than 18,500 operative procedures were reported, with abdominal and soft tissue cases predominating. Many surgeons identified knowledge or practice gaps in predeployment vascular (46%), neurosurgical (29.9%), and orthopedic (28.5%) training. The personal burden of deployment manifested itself with both family (approximately 10% deployment-related divorce rate) and personal (37 surgeons [27%] with two or more symptoms of posttraumatic stress syndrome) stressors. CONCLUSION: These data support modifications of predeployment combat surgical training to include increased exposure to open vascular procedures and curriculum traditionally outside general surgery (neurosurgery and orthopedics). The acute care surgical model may be ideal for the military surgeon preparing for deployment. Further research should be directed toward identifying factors contributing to psychological stress among military medics. (J Trauma Acute Care Surg. 2012;73: S64-S70. Copyright (C) 2012 by Lippincott Williams & Wilkins) C1 [Tyler, Joshua A.] San Antonio Mil Med Ctr, MCHE SDG, Dept Gen Surg, Ft Sam Houston, TX 78234 USA. [Leas, Michelle L.; Eastridge, Brian E.; White, Christopher E.; Rasmussen, Todd E.; Blackbourne, Lorne H.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Edwards, Kurt D.] Tripler Army Med Ctr, Dept Gen Surg, Honolulu, HI 96859 USA. [Knudson, M. Margaret] Univ Calif San Francisco, Dept Surg, San Francisco, CA 94143 USA. RP Tyler, JA (reprint author), San Antonio Mil Med Ctr, MCHE SDG, Dept Gen Surg, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM josh.tyler@amedd.army.mil NR 27 TC 12 Z9 12 U1 0 U2 9 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 2163-0755 J9 J TRAUMA ACUTE CARE JI J. Trauma Acute Care Surg. PD AUG PY 2012 VL 73 SU 1 BP S64 EP S70 DI 10.1097/TA.0b013e3182625ebb PG 7 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 992VP UT WOS:000307808500012 PM 22847097 ER PT J AU Song, DJ Kennebrew, GJ Jex, JW AF Song, Daniel J. Kennebrew, Garry J., Jr. Jex, Jefferson W. TI Isolated Ring Finger Flexor Digitorum Profundus Entrapment After Closed Reduction and Intramedullary Fixation of Both-bone Forearm Fracture SO ORTHOPEDICS LA English DT Article AB Flexor tendon entrapment after a pediatric forearm fracture is a rarely reported complication that is often diagnosed late. Flexor tendon entrapment is more frequently reported after distal forearm fractures, and possible etiologies include fibrosis secondary to hemorrhage at the fracture site and simple entrapment of the muscle belly. This article describes a case of ring finger flexor digitorum profundus entrapment in a 12-year-old boy with a closed both-bone forearm fracture that was treated with closed reduction and intramedullary nail fixation. Preoperatively, the patient had full flexion and extension of all fingers. The entrapment was noted at the first postoperative follow-up when the patient could fully extend the ring finger proximal interphalangeal joint but was unable to concomitantly extend the metacarpal phalangeal joint. Magnetic resonance imaging and ultrasound were obtained to identify the entrapment site. Intraoperatively, a portion of the flexor digitorum profundus musculotendinous junction was entrapped in the fracture site. After release of the entrapment, the patient gained immediate passive range of motion. Subsequently, the hardware was removed, and the patient healed and regained full ring finger function. To the authors' knowledge, this is the only report of isolated ring finger flexor digitorum profundus entrapment after closed reduction and intramedullary fixation of a pediatric forearm fracture. The authors recommend vigilant physical examination of passive and active range of motion of all digital joints with the wrist in flexion and extension before and after bony manipulation. C1 [Song, Daniel J.] Tripler Army Med Ctr, Orthopaed Surg Serv, Honolulu, HI 96859 USA. [Kennebrew, Garry J., Jr.] Loyola Univ, Med Ctr, Chicago, IL 60611 USA. [Jex, Jefferson W.] Walter Reed Natl Mil Med Ctr, Orthopaed Surg Serv, Bethesda, MD USA. RP Song, DJ (reprint author), Tripler Army Med Ctr, Orthopaed Surg Serv, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM song_daniel@hotmail.com NR 4 TC 1 Z9 1 U1 0 U2 0 PU SLACK INC PI THOROFARE PA 6900 GROVE RD, THOROFARE, NJ 08086 USA SN 0147-7447 J9 ORTHOPEDICS JI Orthopedics PD AUG PY 2012 VL 35 IS 8 BP E1283 EP E1285 DI 10.3928/01477447-20120725-36 PG 3 WC Orthopedics SC Orthopedics GA 988UI UT WOS:000307515800026 PM 22868622 ER PT J AU Brill, GN Chen, YP Wijewarnasuriya, PS Dhar, NK AF Brill, Gregory N. Chen, Yuanping Wijewarnasuriya, Priyalal S. Dhar, Nibir K. TI Hg based II-VI compounds on non-standard substrates SO PHYSICA STATUS SOLIDI A-APPLICATIONS AND MATERIALS SCIENCE LA English DT Article DE dislocations; HgCdSe; HgCdTe; infrared ID MOLECULAR-BEAM EPITAXY; WAVELENGTH INFRARED HGCDTE; DETECTORS; SILICON; GROWTH; DISLOCATIONS; PERFORMANCE AB The Army Research Laboratory (ARL) is pursuing scalable infrared (IR) material technologies to meet the growing need for large format arrays. A two pronged approach is being undertaken at ARL using IIVI semiconductor materials. The first encompasses the well developed IR material system HgCdTe but grown on large area, extremely lattice mismatched Si(112) substrates. To overcome the high dislocation density associated with the large mismatch within the as-grown material, ARL has successfully pursued a postgrowth thermal cycle annealing (TCA) process to reduce the dislocation density by an order of magnitude. Current results show HgCdTe/Si material can consistently be achieved with dislocation density values on the order of 1?X?106?cm-2. The second approach involves developing HgCdSe material using lattice matched, large area, and commercially available IIIV substrates, specifically GaSb. Preliminary results indicate that quality HgCdSe growth by molecular beam epitaxy (MBE) can be achieved and that the bandgap of the material can be controlled through the Cd/Se ratio of fluxes used during growth. C1 [Brill, Gregory N.; Chen, Yuanping; Wijewarnasuriya, Priyalal S.; Dhar, Nibir K.] USA, Res Lab, Adelphi, MD 20783 USA. [Dhar, Nibir K.] DARPA, Micro Technol Off, Arlington, VA 22203 USA. RP Brill, GN (reprint author), USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM gregory.n.brill.civ@mail.mil RI Brill, Gregory/G-4877-2013 NR 25 TC 0 Z9 1 U1 0 U2 16 PU WILEY-V C H VERLAG GMBH PI WEINHEIM PA POSTFACH 101161, 69451 WEINHEIM, GERMANY SN 1862-6300 EI 1862-6319 J9 PHYS STATUS SOLIDI A JI Phys. Status Solidi A-Appl. Mat. PD AUG PY 2012 VL 209 IS 8 BP 1423 EP 1427 DI 10.1002/pssa.201100734 PG 5 WC Materials Science, Multidisciplinary; Physics, Applied; Physics, Condensed Matter SC Materials Science; Physics GA 989GP UT WOS:000307548600003 ER PT J AU Wood, M Kovacs, D Bostrom, A Bridges, T Linkov, I AF Wood, Matthew Kovacs, Daniel Bostrom, Ann Bridges, Todd Linkov, Igor TI Flood Risk Management: US Army Corps of Engineers and Layperson Perceptions SO RISK ANALYSIS LA English DT Article DE flood; mental models; risk analysis ID MENTAL MODELS CONCEPTS; GLOBAL CLIMATE-CHANGE; PEOPLE KNOW; IMPACT; KATRINA; HEALTH; RIVERS; CANADA; VIEWS; BASIN AB Recent severe storm experiences in the U.S. Gulf Coast illustrate the importance of an integrated approach to flood preparedness planning that harmonizes stakeholder and agency efforts. Risk management decisions that are informed by and address decision maker and stakeholder risk perceptions and behavior are essential for effective risk management policy. A literature review and two expert models/mental models studies were undertaken to identify areas of importance in the flood risk management process for layperson, non-USACE-expert, and two USACE-expert groups. In characterizing and mapping stakeholder beliefs about risks in the literature onto current risk management practice, recommendations for accommodating and changing stakeholder perceptions of flood risks and their management are identified. Needs of the U.S. Army Corps of Engineers (USACE) flood preparedness and response program are discussed in the context of flood risk mental models. C1 [Wood, Matthew; Bridges, Todd; Linkov, Igor] USA, Corps Engineers, Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA. [Kovacs, Daniel] Decis Partners LLC, Pittsburgh, PA USA. [Bostrom, Ann] Univ Washington, Evans Sch Publ Affairs, Seattle, WA 98195 USA. RP Linkov, I (reprint author), USA, Corps Engineers, Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA. EM Igor.Linkov@usace.army.mil OI Wood, Matthew/0000-0002-1140-1526 FU Civil Works Basic Research Program by the U.S. Army Engineer Research and Development Center FX We would like to thank Drs. Jack Davis and Edmond Russo of the US Army Corps for advice and discussions. Gordon Butte, Sarah Thorne, Alexander Tkachuk, and Laure Canis helped in manuscript preparation and review. Information described and the resulting data presented herein, unless otherwise noted, were obtained from research conducted under the sponsorship of the Civil Works Basic Research Program by the U.S. Army Engineer Research and Development Center. Permission was granted by the USACE Chief of Engineers to publish this material. NR 61 TC 12 Z9 15 U1 1 U2 28 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0272-4332 EI 1539-6924 J9 RISK ANAL JI Risk Anal. PD AUG PY 2012 VL 32 IS 8 BP 1349 EP 1368 DI 10.1111/j.1539-6924.2012.01832.x PG 20 WC Public, Environmental & Occupational Health; Mathematics, Interdisciplinary Applications; Social Sciences, Mathematical Methods SC Public, Environmental & Occupational Health; Mathematics; Mathematical Methods In Social Sciences GA 986ZH UT WOS:000307385700008 PM 22571520 ER PT J AU Sawyer, T Sierocka-Castaneda, A Chan, D Berg, B Lustik, M Thompson, M AF Sawyer, Taylor Sierocka-Castaneda, Agnes Chan, Debora Berg, Benjamin Lustik, Mike Thompson, Mark TI The Effectiveness of Video-Assisted Debriefing Versus Oral Debriefing Alone at Improving Neonatal Resuscitation Performance A Randomized Trial SO SIMULATION IN HEALTHCARE LA English DT Article DE Simulation; Neonatal resuscitation; Facilitated debriefing; Video review; Video-assisted debriefing ID DELIVERY-ROOM ENVIRONMENT; MEDICAL-EDUCATION; FEEDBACK; SIMULATION; SKILLS; TIME AB Introduction: Debriefing is a critical component of effective simulation-based medical education. The optimal format in which to conduct debriefing is unknown. The use of video review has been promoted as a means of enhancing debriefing, and video-assisted debriefing is widely used in simulation training. Few empirical studies have evaluated the impact of video-assisted debriefing, and the results of those studies have been mixed. The objective of this study was to compare the effectiveness of video-assisted debriefing to oral debriefing alone at improving performance in neonatal resuscitation. Methods: Thirty residents, divided into 15 teams of 2 members each, participated in the study. Each team completed a series of 3 neonatal resuscitation simulations. Each simulation was followed by a facilitated debriefing. Teams were randomly assigned to receive either oral debriefing alone or video-assisted debriefing after each simulation. Objective measures of performance and times to complete critical tasks in resuscitation were evaluated by blinded video review on the first (pretest) and the third (posttest) simulations using a previously validated tool. Results: Overall neonatal resuscitation performance scores improved in both groups [mean (SD), 83% (14%) for oral pretest vs. 91% (7%) for oral posttest (P = 0.005); 81% (16%) for video pretest vs. 93% (10%) for video posttest (P < 0.001)]. There was no difference in performance scores between the 2 groups on either the pretest or posttest [overall posttest scores, 91.3% for oral vs. 93.4% for video (P = 0.59)]. Times to complete the critical tasks of resuscitation also did not differ significantly between the 2 study groups. The educational effect of the video-assisted debriefing versus oral debriefing alone was small (d = 0.08). Conclusions: Using this study design, we failed to show a significant educational benefit of video-assisted debriefing. Although our results suggest that the use of video-assisted debriefing may not offer significant advantage over oral debriefing alone, exactly why this is the case remains obscure. Further research is needed to define the optimal role of video review during simulation debriefing in neonatal resuscitation. (Sim Healthcare 7:213-221, 2012) C1 [Sawyer, Taylor; Chan, Debora; Thompson, Mark] Tripler Army Med Ctr, Dept Pediat, Honolulu, HI 96859 USA. [Lustik, Mike] Tripler Army Med Ctr, Dept Clin Invest, Honolulu, HI 96859 USA. [Berg, Benjamin] Univ Hawaii, Telehlth Res Inst, Honolulu, HI 96822 USA. [Sierocka-Castaneda, Agnes] Natl Naval Med Ctr, Dept Pediat, Bethesda, MD USA. RP Sawyer, T (reprint author), Tripler Army Med Ctr, Dept Pediat, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM taylorleesawyer@hotmail.com NR 36 TC 27 Z9 27 U1 2 U2 17 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1559-2332 J9 SIMUL HEALTHC JI Simul. Healthc. PD AUG PY 2012 VL 7 IS 4 BP 213 EP 221 DI 10.1097/SIH.0b013e3182578eae PG 9 WC Health Care Sciences & Services SC Health Care Sciences & Services GA 989IG UT WOS:000307552900002 PM 22673159 ER PT J AU Kelly, E McFarland, MAJD AF Kelly, Elizabeth McFarland, M. A. J. Denise CA Cent Simulation Comm TI Anaphylaxis During General Anesthesia SO SIMULATION IN HEALTHCARE LA English DT Article C1 [McFarland, M. A. J. Denise] Munson Army Hlth Ctr, Anesthesia Serv & Ambulatory Surg Ctr, Ft Leavenworth, KS USA. [Kelly, Elizabeth] USA, Grad Program Anesthesia Nursing, Tripler Army Med Ctr, Honolulu, HI USA. RP McFarland, MAJD (reprint author), Munson Army Hlth Ctr, Anesthesia Serv & Ambulatory Surg Ctr, Ft Leavenworth, KS USA. EM maymcfarland@yahoo.com NR 9 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1559-2332 J9 SIMUL HEALTHC JI Simul. Healthc. PD AUG PY 2012 VL 7 IS 4 BP 261 EP 266 DI 10.1097/SIH.0b013e31824cd329 PG 6 WC Health Care Sciences & Services SC Health Care Sciences & Services GA 989IG UT WOS:000307552900008 PM 22722704 ER PT J AU Rupp, TL Wesensten, NJ Balkin, TJ AF Rupp, Tracy L. Wesensten, Nancy J. Balkin, Thomas J. TI Trait-Like Vulnerability to Total and Partial Sleep Loss SO SLEEP LA English DT Article DE Sleep deprivation; sleep restriction; partial sleep deprivation; individual differences; cognitive performance; mood ID INTERINDIVIDUAL DIFFERENCES; INDIVIDUAL-DIFFERENCES; DOSE-RESPONSE; PERFORMANCE; DEPRIVATION; RESTRICTION; MODEL; VARIABILITY; IMPAIRMENT; ALERTNESS AB Objective: To determine the extent to which individual differences in vulnerability to total sleep deprivation also reflect individual differences in vulnerability to multiple nights of sleep restriction. Design: Two sleep loss conditions (order counterbalanced) separated by 2 to 4 weeks: (a) total sleep deprivation (TSD) of 2 nights (63 h continuous wakefulness); (b) sleep restriction (SR) of 7 nights of 3 h nightly time in bed (TIB). Both conditions were preceded by 7 in-laboratory nights with 10 h nightly TIB; and followed by 3 recovery nights with 8 h nightly TIB. Measures of cognitive performance (psychomotor vigilance, working memory [1-Back], and mathematical processing), objective alertness, subjective sleepiness, and mood were obtained at regular intervals under both conditions. Intra-class correlation coefficients (ICC) were computed using outcome metrics averaged over the last day (08:00-20:00) of TSD and SR. Setting: Residential sleep/performance testing facility. Participants: Nineteen healthy adults (ages 18-39; 11 males, 8 females). Interventions: 2 nights of TSD and 7 nights SR (3 h nightly TIB). Results: Volunteers who displayed greater vulnerability to TSD displayed greater vulnerability to SR on cognitive performance tasks (ICC: PVT lapses = 0.89; PVT speed = 0.86; 1-Back = 0.88; mathematical processing = 0.68, Ps < 0.05). In addition, trait-like responsivity to TSD/SR was found for mood variables vigor (ICC = 0.91), fatigue (ICC = 0.73), and happiness (ICC = 0.85) (all Ps < 0.05). Conclusion: Resilience to sleep loss is a trait-like characteristic that reflects an individual's ability to maintain performance during both types of sleep loss (SR and TSD). Whether the findings extend to sleep schedules other than those investigated here (63 h of TSD and 7 nights of 3 h nightly TIB) will be the focus of future studies. C1 [Rupp, Tracy L.; Wesensten, Nancy J.; Balkin, Thomas J.] Walter Reed Army Inst Res, Behav Biol Branch, Ctr Mil Psychiat & Neurosci, Silver Spring, MD 20910 USA. RP Wesensten, NJ (reprint author), Walter Reed Army Inst Res, Behav Biol Branch, Ctr Mil Psychiat & Neurosci, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM nancy.wesensten@us.army.mil FU US Army Medical Research and Materiel Command FX This work was supported by the US Army Medical Research and Materiel Command. We thank the student contractors, military personnel, on-call physicians Drs. John Hughes and LTC Melanie Guerrero. and study volunteers for their dedicated work and participation in the study. NR 34 TC 41 Z9 41 U1 1 U2 9 PU AMER ACAD SLEEP MEDICINE PI WESTCHESTER PA ONE WESTBROOK CORPORATE CTR, STE 920, WESTCHESTER, IL 60154 USA SN 0161-8105 J9 SLEEP JI Sleep PD AUG 1 PY 2012 VL 35 IS 8 BP 1163 EP 1172 DI 10.5665/sleep.2010 PG 10 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA 983CT UT WOS:000307094900018 PM 22851812 ER PT J AU Watts, DB Arriaga, FJ Torbert, HA Busby, RR Gebhart, DL AF Watts, Dexter B. Arriaga, Francisco J. Torbert, H. Allen Busby, Ryan R. Gebhart, Dick L. TI Noncomposted Municipal Solid Waste Byproduct Influences Soil and Plant Nutrients 5 Years After Soil Reclamation SO SOIL SCIENCE LA English DT Article DE Municipal solid waste; soil restoration; plant nutrients ID COMPOST; CARBON; TILLAGE AB Concerns for the mounting supply of municipal solid waste being generated combined with decreasing landfill space have compelled military installations to evaluate alternative methods for disposal. One approach to reduce landfilling is the use of a new garbage-processing technology that sterilizes and separates the waste into inorganic and organic components. Thus, a study was initiated to evaluate the effectiveness of using the organic component (Fluff) as a soil amendment for reclamation of disturbed US Army training land. The Fluff material was initially incorporated (10-20 cm) into a highly degraded sandy loam soil (fine-loamy, kaolinitic, thermic Typic Kandiudults) located in a borrow pit at Fort Benning Military Reservation, Georgia, in 2003. The Fluff was applied at rates of 0, 18, 36, 72, and 143 Mg ha(-1), and the soil was seeded with native prairie grasses. Soil nutrient retention and plant uptake were evaluated to determine the soil-plant system's sustainability after 5 years. An unseeded control was also evaluated as a comparison of natural recovery. Five years after reclamation, vegetation resulting from natural recovery in the unseeded control was sparse. Fluff addition increased pH, organic matter, and plant nutrient availability in the degraded soil, with the greatest improvements occurring at higher application rates. Soil productivity improvements resulted in greater plant biomass production. Generally, plant nutrient concentrations were not significantly impacted by Fluff addition. However, plant nutrient content was consistently higher with Fluff addition, which was attributed to increased biomass production. Plant nutrient uptakes of N, Ca, Mg, B, Mn, and Zn were within the reference range for grasses, whereas P and K concentrations were slightly deficient. An Fe and Cu concentration toxicity problem at the borrow site was alleviated with higher Fluff application rates, whereas the control and lower Fluff rates accumulated high levels of Fe and Cu within plant tissues. These results suggest that Fluff can be effectively used in land rehabilitation and revegetation practices to create a sustainable native grassland ecosystem. C1 [Watts, Dexter B.; Arriaga, Francisco J.; Torbert, H. Allen] USDA ARS, Natl Soil Dynam Lab, Auburn, AL 36832 USA. [Busby, Ryan R.; Gebhart, Dick L.] USA, Construct Engn Res Lab, Ecol Proc Branch, Engn Res & Dev Ctr, Champaign, IL 61824 USA. RP Watts, DB (reprint author), USDA ARS, Natl Soil Dynam Lab, 411 S Donahue Dr, Auburn, AL 36832 USA. EM Dexter.Watts@ars.usda.gov NR 34 TC 0 Z9 0 U1 2 U2 23 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0038-075X J9 SOIL SCI JI Soil Sci. PD AUG PY 2012 VL 177 IS 8 BP 480 EP 489 DI 10.1097/SS.0b013e318268a246 PG 10 WC Soil Science SC Agriculture GA 989HL UT WOS:000307550800002 ER PT J AU Song, XY Chen, Y Chen, S Barbero, E Thomas, EL Barnes, P AF Song, Xueyan Chen, Yun Chen, Song Barbero, Ever Thomas, Evan L. Barnes, Paul TI Significant enhancement of electrical transport properties of thermoelectric Ca3Co4O9+delta through Yb doping SO SOLID STATE COMMUNICATIONS LA English DT Article DE Thermoelectric materials; Cobalt oxide; Substitution; Transmission electron microscopy ID OXIDE; SYSTEM; POWER AB We report the significant enhancement of the power factor of Ca3Co4O9+delta through Yb doping. The pellets were prepared by pressing under 0.5 GPa and 2 GPa. The highest power factor of 553 mu W m(-1) K-2 due to the significant increase of electrical conductivity was obtained for Ca2.9Yb0.1Co4O9+delta pressed at 0.5 GPa. This is 2.3 times higher than that of Ca3Co4O9+delta (246 mu W m(-1) K-2). Nanostructure examinations show that the pellets pressed at 0.5 and 2 GPa have different nano-lamella structures. This work suggests that Yb is an effective doping element for enhancing the electrical transport properties of Ca3Co4O9+delta, and the optimum doping level is related to the nanostructure of the bulk pellets. (C) 2012 Elsevier Ltd. All rights reserved. C1 [Song, Xueyan; Chen, Yun; Chen, Song; Barbero, Ever] W Virginia Univ, Dept Mech & Aerosp Engn, Morgantown, WV 26506 USA. [Thomas, Evan L.] Univ Dayton, Res Inst, AF Res Lab WPAFB, Energy Technol & Mat Div, Dayton, OH 45469 USA. [Barnes, Paul] USA, Res Lab, Adelphi, MD 20783 USA. RP Song, XY (reprint author), W Virginia Univ, Dept Mech & Aerosp Engn, Evansdale Dr, Morgantown, WV 26506 USA. EM xueyan.song@mail.wvu.edu RI Chen, Song/H-3174-2011 NR 16 TC 9 Z9 9 U1 0 U2 33 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0038-1098 J9 SOLID STATE COMMUN JI Solid State Commun. PD AUG PY 2012 VL 152 IS 16 BP 1509 EP 1512 DI 10.1016/j.ssc.2012.06.014 PG 4 WC Physics, Condensed Matter SC Physics GA 982JQ UT WOS:000307039700001 ER PT J AU Klein, TA Kim, HC Chong, ST O'Guinn, ML Lee, JS Turell, MJ Sames, WJ Gu, SH Kang, HJ Moon, S Lee, SY Chun, Y Song, JW AF Klein, Terry A. Kim, Heung-Chul Chong, Sung-Tae O'Guinn, Monica L. Lee, John S. Turell, Michael J. Sames, William J. Gu, Se Hun Kang, Hae Ji Moon, Sungsil Lee, Sook-Young Chun, YuJin Song, Jin-Won TI Hantaan Virus Surveillance in Small Mammals at Firing Points 10 and 60, Yeoncheon, Gyeonggi Province, Republic of Korea SO VECTOR-BORNE AND ZOONOTIC DISEASES LA English DT Article DE Apodemus agrarius; Crocidura lasiura; Epidemiology; Military; Phylogeny ID VOLES CLETHRIONOMYS-GLAREOLUS; NORTH TRAINING AREA; SIN-NOMBRE-VIRUS; HANTAVIRUS INFECTION; ECOLOGICAL SURVEILLANCE; RODENT POPULATIONS; HUMANS; SWEDEN; RISK; RATS AB We used epidemiological data and indirect fluorescent antibody tests to determine the Hantaan virus (HTNV) antibody-positive (Ab +) prevalence in small mammals captured at firing point 10 (FP-10) and firing point 60 (FP-60), Gyeonggi Province, near the demilitarized zone, Republic of Korea (ROK), from 2001 to 2005. We used these data, combined with the partial M segment amplified from HTNV recovered from lung tissues of Apodemus agrarius, to clarify the genetic diversity and phylogenetic relationships among HTNV strains in the ROK. Of the eight species of rodents and one insectivore species captured, A. agrarius accounted for 93.4% and 88.5% at FP-10 and FP-60, respectively. Only two species of rodents, A. agrarius and Micromys minutus, were HTNV Ab +. The overall HTNV Ab + prevalence for A. agrarius captured at FP-10 and FP-60 was 23.3% (121/520) and 14.5% (94/647), respectively. The hantaviral reverse transcription-polymerase chain reaction-positive rate of Ab + A. agrarius was 74.2% (167/215), and the phylogenetic trees, based on the 269-nucleotide G2-encoding M segment, demonstrated that HTNV strains from FP-10 and FP-60 were distantly segregated from HTNV of other geographic regions in Korea and China. These data are useful in the development of risk reduction strategies for the prevention of hantavirus infections among military personnel, especially during training or the event of hostilities, and civilian populations. C1 [Gu, Se Hun; Kang, Hae Ji; Lee, Sook-Young; Chun, YuJin; Song, Jin-Won] Korea Univ, Coll Med, Inst Viral Dis, Dept Microbiol, Seoul 136705, South Korea. [Klein, Terry A.] 65th Med Brigade USAMEDDAC Korea, Unit 15281, APO, AP 96205 USA. [Kim, Heung-Chul; Chong, Sung-Tae] 65th Med Brigade, Unit 15247, APO, AP 96205 USA. [Sames, William J.] Med Entomol Consultant, Leakey, TX USA. [Moon, Sungsil] Ctr Dis Control & Prevent, Div Viral Dis, Atlanta, GA USA. [O'Guinn, Monica L.; Lee, John S.; Turell, Michael J.] US Army Med Res Inst Infect Dis, Dept Vector Assessment, Ft Detrick, MD USA. RP Song, JW (reprint author), Korea Univ, Coll Med, Inst Viral Dis, Dept Microbiol, 126-1,5Ka Anam Dong, Seoul 136705, South Korea. EM jwsong@korea.ac.kr RI Valle, Ruben/A-7512-2013 FU Armed Forces Health Surveillance Center; Division of Global Emerging Infections Surveillance and Response System Operations, Silver Spring; National Center for Medical Intelligence, Ft. Detrick FX We thank COL Brian Allgood (deceased) and COL Hee-Choon (Sam) Lee, 18th Medical Command, Seoul, Korea, for their support in conducting rodent-borne disease surveillance. We thank Ms. Suk Hee Yi, Force Health Protection, 65th Medical Brigade, Seoul, Korea, for conducting data analysis and GIS mapping, and MAJ Rex Bergren and LTC Min Ro, Chief, Laboratory Services, USAMEDDAC-Korea, Seoul Korea, for their support. We thank COL Ronald Smith, Commander, USAMEDDAC-Korea, LTC Mitchell Meyers, Chief, Force Health Protection and Preventive Medicine, 65th Medical Brigade, Seoul, Korea, and Dr. Joel Gaydos, Armed Forces Health Surveillance Center, Silver Spring, MD, for their support throughout the study.; Funding for portions of this work was provided by the Armed Forces Health Surveillance Center, Division of Global Emerging Infections Surveillance and Response System Operations, Silver Spring, MD, and the National Center for Medical Intelligence, Ft. Detrick, MD. NR 38 TC 5 Z9 5 U1 1 U2 4 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1530-3667 J9 VECTOR-BORNE ZOONOT JI Vector-Borne Zoonotic Dis. PD AUG PY 2012 VL 12 IS 8 BP 674 EP 682 DI 10.1089/vbz.2011.0618 PG 9 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA 988UH UT WOS:000307515700008 PM 22607077 ER EF