FN Thomson Reuters Web of Science™ VR 1.0 PT J AU Sluss, DM Ployhart, RE Cobb, MG Ashforth, BE AF Sluss, David M. Ployhart, Robert E. Cobb, M. Glenn Ashforth, Blake E. TI GENERALIZING NEWCOMERS' RELATIONAL AND ORGANIZATIONAL IDENTIFICATIONS: PROCESSES AND PROTOTYPICALITY SO ACADEMY OF MANAGEMENT JOURNAL LA English DT Article ID LEADER-MEMBER EXCHANGE; SOCIAL IDENTITY THEORY; PERCEIVED SUPERVISOR SUPPORT; PROFESSIONAL IDENTIFICATION; SOCIALIZATION TACTICS; EMPLOYEE PERFORMANCE; INFORMATION-SEEKING; SELF-CONSISTENCY; FIT INDEXES; WORK AB A recent theoretical proposal is that relational identification generalizes to organizational identification through affective, cognitive, and behavioral mediating mechanisms. The generalization process is strengthened when a relational other is prototypical that is, is seen as promoting core organizational values. We investigate these propositions via two field studies. First, we find, via temporally lagged data from 186 newcomers to the telemarketing industry, that relational identification with a supervisor generalizes to organizational identification through affective (i.e., affect transfer), cognitive (i.e., social influence), and behavioral (i.e., behavioral "sensemaking") mediating mechanisms. Second, we find, via temporally lagged data from 1,101 newcomers to the U.S. Army, that a newcomer's relational identification with his/her supervisor generalizes to the newcomer's organizational identification, but only when the supervisor is perceived to be prototypical. Our combined findings suggest that (1) multiple identifications are more integrative than exclusive and (2) organizational membership may be more personalized and relational than previously assumed in extant research. C1 [Sluss, David M.] Georgia Inst Technol, Scheller Coll Business, Atlanta, GA 30332 USA. [Ployhart, Robert E.] Univ S Carolina, Darla Moore Sch Business, Columbia, SC 29208 USA. [Cobb, M. Glenn] US Army Res Inst, Ft Benning, GA USA. [Ashforth, Blake E.] Arizona State Univ, WP Carey Sch Business, Tempe, AZ 85287 USA. RP Sluss, DM (reprint author), Georgia Inst Technol, Scheller Coll Business, Atlanta, GA 30332 USA. EM david.sluss@mgt.gatech.edu; ployhart@moore.sc.edu; marshell.g.cobb.civ@mail.mil; blake.ashforth@asu.edu NR 139 TC 41 Z9 44 U1 10 U2 142 PU ACAD MANAGEMENT PI BRIARCLIFF MANOR PA PACE UNIV, PO BOX 3020, 235 ELM RD, BRIARCLIFF MANOR, NY 10510-8020 USA SN 0001-4273 EI 1948-0989 J9 ACAD MANAGE J JI Acad. Manage. J. PD AUG PY 2012 VL 55 IS 4 BP 949 EP 975 DI 10.5465/amj.2010.0420 PG 27 WC Business; Management SC Business & Economics GA 987NW UT WOS:000307425200009 ER PT J AU Perkins, MW Pierre, Z Sabnekar, P Sciuto, AM Song, J Soojhawon, I Oguntayo, S Doctor, BP Nambiar, MP AF Perkins, Michael W. Pierre, Zdenka Sabnekar, Praveena Sciuto, Alfred M. Song, Jian Soojhawon, Iswarduth Oguntayo, Samuel Doctor, Bhupendra P. Nambiar, Madhusoodana P. TI Aerosolized delivery of oxime MMB-4 in combination with atropine sulfate protects against soman exposure in guinea pigs SO INHALATION TOXICOLOGY LA English DT Article DE Chemical warfare nerve agents; MMB-4; Atropine sulfate; Respiratory toxicity; Lung injury; Cholinesterase; Inhalation exposure; Soman ID MICROINSTILLATION INHALATION EXPOSURE; NONNEURONAL CHOLINERGIC SYSTEM; TISSUE CHOLINESTERASE ACTIVITY; INDUCED RESPIRATORY DEPRESSION; NERVE AGENTS; HUMAN ACETYLCHOLINESTERASE; SEIZURE ACTIVITY; KINETIC APPROACH; EFFICACY; TOXICITY AB We evaluated the efficacy of aerosolized acetylcholinesterase (AChE) reactivator oxime MMB-4 in combination with the anticholinergic atropine sulfate for protection against respiratory toxicity and lung injury following microinstillation inhalation exposure to nerve agent soman (GD) in guinea pigs. Anesthetized animals were exposed to GD (841 mg/m(3), 1.2 LCt(50)) and treated with endotracheally aerosolized MMB-4 (50 mu mol/kg) plus atropine sulfate (0.25 mg/kg) at 30 sec post-exposure. Treatment with MMB-4 plus atropine increased survival to 100% compared to 38% in animals exposed to GD. Decreases in the pulse rate and blood O-2 saturation following exposure to GD returned to normal levels in the treatment group. The body-weight loss and lung edema was significantly reduced in the treatment group. Similarly, bronchoalveolar cell death was significantly reduced in the treatment group while GD-induced increase in total cell count was decreased consistently but was not significant. GD-induced increase in bronchoalveolar protein was diminished after treatment with MMB-4 plus atropine. Bronchoalveolar lavage AChE and BChE activity were significantly increased in animals treated with MMB-4 plus atropine at 24 h. Lung and diaphragm tissue also showed a significant increase in AChE activity in the treatment group. Treatment with MMB-4 plus atropine sulfate normalized various respiratory dynamics parameters including respiratory frequency, tidal volume, peak inspiratory and expiratory flow, time of inspiration and expiration, enhanced pause and pause post-exposure to GD. Collectively, these results suggest that aerosolization of MMB-4 plus atropine increased survival, decreased respiratory toxicity and lung injury following GD inhalation exposure. C1 [Song, Jian; Soojhawon, Iswarduth; Oguntayo, Samuel; Doctor, Bhupendra P.; Nambiar, Madhusoodana P.] Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci, Blast Induced Neurotrauma Branch, Silver Spring, MD 20910 USA. [Perkins, Michael W.; Pierre, Zdenka; Sabnekar, Praveena; Sciuto, Alfred M.] USA, Med Res Inst Chem Def, Silver Spring, MD USA. [Nambiar, Madhusoodana P.] Uniformed Serv Univ Hlth Sci, Dept Med, Bethesda, MD 20814 USA. RP Nambiar, MP (reprint author), Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci, Blast Induced Neurotrauma Branch, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM madhusoodana.nambiar@amedd.army.mil FU Defense Threat Reduction Agency FX The project was supported by Defense Threat Reduction Agency. Its contents, opinions and assertions contained herein are private views of the authors are not to be construed as official or reflecting the views of the Department of the Army or the Department of Defense. NR 53 TC 2 Z9 2 U1 0 U2 6 PU INFORMA HEALTHCARE PI LONDON PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND SN 0895-8378 J9 INHAL TOXICOL JI Inhal. Toxicol. PD AUG PY 2012 VL 24 IS 9 BP 539 EP 549 DI 10.3109/08958378.2012.691912 PG 11 WC Toxicology SC Toxicology GA 983HT UT WOS:000307111100001 PM 22860999 ER PT J AU Olevsky, EA Bradbury, WL Haines, CD Martin, DG Kapoor, D AF Olevsky, Eugene A. Bradbury, William L. Haines, Christopher D. Martin, Darold G. Kapoor, Deepak TI Fundamental Aspects of Spark Plasma Sintering: I. Experimental Analysis of Scalability SO JOURNAL OF THE AMERICAN CERAMIC SOCIETY LA English DT Article ID TRANSPARENT ALUMINA; COMBUSTION SYNTHESIS; DENSIFICATION; CERAMICS; STRENGTH; SPS; POWDER; PRESSURE; FIELD; MICROSTRUCTURE AB Scalability experiments on the spark plasma sintering (SPS) of similarly shaped alumina specimens of the four different sizes are conducted. The utilized experimental methodology, based on the principle of rigorous proportionality of all the specimen and tooling dimensions, employs two different SPS devices of different scales. The processed specimens are characterized in terms of relative density and grain-pore structure. Overall, SPS shows good scalability potential within a single SPS device, but indicates substantial structure changes when switching between different SPS devices. Despite deviations in some cases, by and large, the experimental results obtained for different tooling sizes and temperature regimes are rather similar for specimens processed by the same SPS device. The obtained density and grain size spatial distributions are relatively uniform. High final densities with moderate grain growth are common. At the same time, due to the demonstrated possibility of a significant size impact in case of high heating rates and large specimen sizes, as well as the demonstrated differences of the processing outcomes based on different SPS devices, the predictive capability of reliable modeling approaches is of great importance for the industrial implementation of SPS techniques. C1 [Olevsky, Eugene A.; Bradbury, William L.] San Diego State Univ, San Diego, CA 92182 USA. [Haines, Christopher D.; Martin, Darold G.; Kapoor, Deepak] USA, ARDEC, Picatinny Arsenal, NJ 07806 USA. RP Olevsky, EA (reprint author), San Diego State Univ, 5500 Campanile Dr, San Diego, CA 92182 USA. EM eolevsky@mail.sdsu.edu FU US Army ARDEC, Picatinny Arsenal [W15QKN-09C-0128]; National Science Foundation, Division of Civil, Mechanical, and Manufacturing Innovations [CMMI- 0758232]; Major Instrumentation Research Program [DBI-0959908] FX The support of US Army ARDEC, Picatinny Arsenal (Contract Award #W15QKN-09C-0128) is gratefully appreciated. The support of the National Science Foundation, Division of Civil, Mechanical, and Manufacturing Innovations (Grant CMMI- 0758232) and Major Instrumentation Research Program (Grant DBI-0959908) is gratefully appreciated. The authors acknowledge the assistance of Dr. Steve Barlow, and use of the San Diego State University Electron Microscopy Facility. NR 54 TC 23 Z9 23 U1 0 U2 36 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0002-7820 J9 J AM CERAM SOC JI J. Am. Ceram. Soc. PD AUG PY 2012 VL 95 IS 8 SI SI BP 2406 EP 2413 DI 10.1111/j.1551-2916.2012.05203.x PG 8 WC Materials Science, Ceramics SC Materials Science GA 983EJ UT WOS:000307101000007 ER PT J AU Olevsky, EA Garcia-Cardona, C Bradbury, WL Haines, CD Martin, DG Kapoor, D AF Olevsky, Eugene A. Garcia-Cardona, Cristina Bradbury, William L. Haines, Christopher D. Martin, Darold G. Kapoor, Deepak TI Fundamental Aspects of Spark Plasma Sintering: II. Finite Element Analysis of Scalability SO JOURNAL OF THE AMERICAN CERAMIC SOCIETY LA English DT Article ID ELECTRIC-FIELD; TEMPERATURE DISTRIBUTION; DENSIFICATION; SIMULATION; PRESSURE; EVOLUTION; STRESS; POWDER; SPS; DISTRIBUTIONS AB A comprehensive three-dimensional fully coupled thermo-electro-mechanical finite element framework is developed for modeling spark plasma sintering (SPS). The finite element model is applied to the simulation of spark plasma processing with four different tooling sizes and various temperature regimes. The comparison of modeling and experimental results shows that the model is reliable for qualitative predictions of the densification behavior and of the grain growth in powder specimens subjected to SPS with a given temperature regime. The conducted modeling indicates the possibility of changing the heating pattern of the specimen (warmer central areas of the specimen's volume and cooler outside areas or vice versa) depending on the size of the tooling. High heating rates and large specimen sizes elevate the temperature and, in turn, material structure gradients during SPS processing. The obtained results suggest that the industrial implementation of SPS techniques should be based on the predictive capability of reliable modeling approaches. C1 [Olevsky, Eugene A.; Garcia-Cardona, Cristina; Bradbury, William L.] San Diego State Univ, San Diego, CA 92182 USA. [Haines, Christopher D.; Martin, Darold G.; Kapoor, Deepak] USA, ARDEC, Picatinny Arsenal, NJ 07806 USA. RP Olevsky, EA (reprint author), San Diego State Univ, 5500 Campanile Dr, San Diego, CA 92182 USA. EM eolevsky@mail.sdsu.edu FU US Army ARDEC, Picatinny Arsenal [W15QKN-09C-0128]; National Science Foundation, Division of Civil, Mechanical, and Manufacturing Innovations [CMMI 0758232] FX The support of US Army ARDEC, Picatinny Arsenal (Contract Award #W15QKN-09C-0128) is gratefully appreciated. The support of the National Science Foundation, Division of Civil, Mechanical, and Manufacturing Innovations (Grant CMMI 0758232) is gratefully appreciated. NR 45 TC 43 Z9 43 U1 1 U2 27 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0002-7820 J9 J AM CERAM SOC JI J. Am. Ceram. Soc. PD AUG PY 2012 VL 95 IS 8 SI SI BP 2414 EP 2422 DI 10.1111/j.1551-2916.2012.05096.x PG 9 WC Materials Science, Ceramics SC Materials Science GA 983EJ UT WOS:000307101000008 ER PT J AU Castro, CA Adler, AB McGurk, D Bliese, PD AF Castro, Carl Andrew Adler, Amy B. McGurk, Dennis Bliese, Paul D. TI Mental health training with soldiers four months after returning from iraq: Randomization by platoon SO JOURNAL OF TRAUMATIC STRESS LA English DT Article ID VALIDATION; COMBAT; TRIAL; CARE AB Military personnel report significant and increasing mental health problems in the months following return from combat. Nevertheless, studies have not assessed the impact of mental health training with this at-risk population. The present study evaluated the efficacy of a prototype mental health training module designed for U.S. soldiers 36 months after returning from combat; the module was a component of the Battlemind Training system. Soldiers (N = 1,645) were randomly assigned by platoon to 1 hour of training or a survey-only control group. Baseline surveys were conducted immediately before training; a training satisfaction survey was administered immediately after training, and a follow-up survey was administered 6 months later. Immediate postsession surveys were conducted with 681 subjects, and follow-up surveys were conducted with 542 soldiers. The Battlemind Training module received positive ratings from participants, and those who received it reported significantly better adjustment in terms of posttraumatic stress disorder symptoms, depression, and life satisfaction at follow-up compared to those in the survey-only control group. Changes in attitudes about the stigma of seeking mental health care were found immediately posttraining, but not at follow-up. The findings demonstrate that brief mental health training can be effective in reducing mental health systems with at-risk occupational groups. C1 [Castro, Carl Andrew] Med Res & Mat Command, Mil Operat Med Res Program, Frederick, MD USA. [Adler, Amy B.; McGurk, Dennis] Walter Reed Army Inst Res, US Army Med Res Unit Europe, Heidelberg, Germany. [Bliese, Paul D.] Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci, Forest Glenn, MD USA. RP Adler, AB (reprint author), USA, Med Res Unit, APO, AE 09042 USA. EM amy.adler@us.army.mil NR 24 TC 16 Z9 16 U1 0 U2 4 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0894-9867 J9 J TRAUMA STRESS JI J. Trauma Stress PD AUG PY 2012 VL 25 IS 4 BP 376 EP 383 DI 10.1002/jts.21721 PG 8 WC Psychology, Clinical; Psychiatry SC Psychology; Psychiatry GA 983HI UT WOS:000307110000003 PM 22833447 ER PT J AU Jacobs, LM Nawaz, MK Hood, JL Bae, S AF Jacobs, Linda M. Nawaz, Muhammad K. Hood, Joyce L. Bae, Sejong TI Burnout Among Workers in a Pediatric Health Care System SO WORKPLACE HEALTH & SAFETY LA English DT Article ID QUALITY-OF-CARE; JOB-SATISFACTION; OUTCOMES; NURSES; STRESS; PUMA AB Burnout among health care workers is recognized as an organizational risk contributing to absenteeism, presenteeism, excessive turnover, or illness, and may also manifest as decreased patient satisfaction. Pediatric health care may add stressors including worried parents of ill or dying children, child custody issues, child abuse, and workplace violence. The purpose of this study was to measure burnout among workers in a regional pediatric health care system and report whether burnout in a pediatric health care system is different from previously published data on human service workers. The Maslach Burnout Inventory Human Services Survey (MBI-HSS) and the Copenhagen Burnout Inventory (CBI) were used to measure burnout. Pediatric health care workers expressed significantly less burnout as compared to published MBI-HSS scores and client-related CBI scores. Personal burnout CBI scores were not different, but work-related CBI scores were significantly higher than normative scores. C1 [Jacobs, Linda M.] Cook Childrens Hlth Care Syst, Dept Educ, Occupat Hlth Serv, Ft Worth, TX 76104 USA. [Nawaz, Muhammad K.] USA, Med Dept Regiment, Ft Hood, TX USA. [Bae, Sejong] Univ N Texas, Sch Publ Hlth, Dept Biostat, Hlth Sci Ctr, Ft Worth, TX USA. RP Jacobs, LM (reprint author), Cook Childrens Hlth Care Syst, Dept Educ, Occupat Hlth Serv, 801 7th Ave, Ft Worth, TX 76104 USA. EM linda.jacobs@cookchildrens.org NR 24 TC 5 Z9 5 U1 3 U2 16 PU SLACK INC PI THOROFARE PA 6900 GROVE RD, THOROFARE, NJ 08086 USA SN 2165-0799 J9 WORKPLACE HEALTH SAF JI Workplace Health Saf. PD AUG PY 2012 VL 60 IS 8 BP 335 EP 344 DI 10.3928/21650799-20120726-03 PG 10 WC Nursing SC Nursing GA 987PJ UT WOS:000307429300003 PM 22850134 ER PT J AU Gaitonde, DY Rowley, KD Sweeney, LB AF Gaitonde, David Y. Rowley, Kevin D. Sweeney, Lori B. TI Hypothyroidism: An Update SO AMERICAN FAMILY PHYSICIAN LA English DT Article ID THYROID-DYSFUNCTION; MYXEDEMA COMA; THYROXINE; LEVOTHYROXINE; GUIDELINES; THERAPY; HYPERTHYROIDISM; THYROTROPIN; MANAGEMENT; TRIAL AB Hypothyroidism is a clinical disorder commonly encountered by the primary care physician. Untreated hypothyroidism can contribute to hypertension, dyslipidemia, infertility, cognitive impairment, and neuromuscular dysfunction. Data derived from the National Health and Nutrition Examination Survey suggest that about one in 300 persons in the United States has hypothyroidism. The prevalence increases with age, and is higher in females than in males. Hypothyroidism may occur as a result of primary gland failure or insufficient thyroid gland stimulation by the hypothalamus or pituitary gland. Autoimmune thyroid disease is the most common etiology of hypothyroidism in the United States. Clinical symptoms of hypothyroidism are nonspecific and may be subtle, especially in older persons. The best laboratory assessment of thyroid function is a serum thyroid-stimulating hormone test. There is no evidence that screening asymptomatic adults improves outcomes. In the majority of patients, alleviation of symptoms can be accomplished through oral administration of synthetic levothyroxine, and most patients will require lifelong therapy. Combination triiodothyronine/thyroxine therapy has no advantages over thyroxine monotherapy and is not recommended. Among patients with subclinical hypothyroidism, those at greater risk of progressing to clinical disease, and who may be considered for therapy, include patients with thyroid-stimulating hormone levels greater than 10 mIU per L and those who have elevated thyroid peroxidase antibody titers. (Am Fam Physician. 2012;86 (3):244-251. Copyright (c) 2012 American Academy of Family Physicians.) C1 [Gaitonde, David Y.; Sweeney, Lori B.] Dwight D Eisenhower Army Med Ctr, Dept Endocrinol, Ft Gordon, GA 30905 USA. [Rowley, Kevin D.] Dwight D Eisenhower Army Med Ctr, Dept Med, Ft Gordon, GA USA. RP Gaitonde, DY (reprint author), Dwight D Eisenhower Army Med Ctr, Dept Endocrinol, 300 W Hosp Rd, Ft Gordon, GA 30905 USA. EM david.gaitonde@us.army.mil NR 34 TC 19 Z9 20 U1 0 U2 23 PU AMER ACAD FAMILY PHYSICIANS PI KANSAS CITY PA 8880 WARD PARKWAY, KANSAS CITY, MO 64114-2797 USA SN 0002-838X J9 AM FAM PHYSICIAN JI Am. Fam. Physician PD AUG 1 PY 2012 VL 86 IS 3 BP 244 EP 251 PG 8 WC Primary Health Care; Medicine, General & Internal SC General & Internal Medicine GA 983XR UT WOS:000307152500006 PM 22962987 ER PT J AU Shatalov, M Sun, WH Lunev, A Hu, XH Dobrinsky, A Bilenko, Y Yang, JW Shur, M Gaska, R Moe, C Garrett, G Wraback, M AF Shatalov, Max Sun, Wenhong Lunev, Alex Hu, Xuhong Dobrinsky, Alex Bilenko, Yuri Yang, Jinwei Shur, Michael Gaska, Remis Moe, Craig Garrett, Gregory Wraback, Michael TI AlGaN Deep-Ultraviolet Light-Emitting Diodes with External Quantum Efficiency above 10% SO APPLIED PHYSICS EXPRESS LA English DT Article ID EMISSION; NITRIDE AB Improvements of the internal quantum efficiency by reduction of the threading dislocation density and of the light extraction by using UV transparent p-type cladding and contact layers, UV reflecting ohmic contact, and chip encapsulation with optimized shape and refractive index allowed us to obtain the external quantum efficiency of 10.4% at 20mA CW current with the output power up to 9.3 mW at 278 nm for AlGaN-based deep-ultraviolet light-emitting diodes grown on sapphire substrates. (C) 2012 The Japan Society of Applied Physics C1 [Shatalov, Max; Sun, Wenhong; Lunev, Alex; Hu, Xuhong; Dobrinsky, Alex; Bilenko, Yuri; Yang, Jinwei; Gaska, Remis] Sensor Elect Technol Inc, Columbia, SC 29209 USA. [Shur, Michael] Rensselaer Polytech Inst, Dept Elect Comp & Syst Engn, Troy, NY 12180 USA. [Shur, Michael] Rensselaer Polytech Inst, Ctr Integrated Elect, Troy, NY 12180 USA. [Moe, Craig; Garrett, Gregory; Wraback, Michael] USA, Res Lab, Adelphi, MD 20783 USA. RP Shatalov, M (reprint author), Sensor Elect Technol Inc, Columbia, SC 29209 USA. EM shatalov@s-et.com RI Shur, Michael/A-4374-2016 OI Shur, Michael/0000-0003-0976-6232 FU Defense Advanced Research Program Agency [W911NF-10-2-0023]; U.S. Army Research Laboratory [W911NF-10-2-0023] FX Work at Sensor Electronic Technology was supported by the Defense Advanced Research Program Agency (Dr. J. Albrecht) through a cooperative research agreement W911NF-10-2-0023 with the U.S. Army Research Laboratory (Dr. M. Wraback). The authors also would like to thank Dr. Z. Liliental-Weber from Lawrence Berkley National Laboratory for TEM analysis of epitaxial structures. NR 8 TC 134 Z9 139 U1 12 U2 115 PU JAPAN SOC APPLIED PHYSICS PI TOKYO PA KUDAN-KITA BUILDING 5TH FLOOR, 1-12-3 KUDAN-KITA, CHIYODA-KU, TOKYO, 102-0073, JAPAN SN 1882-0778 J9 APPL PHYS EXPRESS JI Appl. Phys. Express PD AUG PY 2012 VL 5 IS 8 AR 082101 DI 10.1143/APEX.5.082101 PG 3 WC Physics, Applied SC Physics GA 986XT UT WOS:000307381500011 ER PT J AU Gaydos, SJ Harrigan, MJ Bushby, AJR AF Gaydos, Steven J. Harrigan, Michael J. Bushby, Alastair J. R. TI Ten Years of Spatial Disorientation in U.S. Army Rotary-Wing Operations SO AVIATION SPACE AND ENVIRONMENTAL MEDICINE LA English DT Article DE spatial disorientation; aircraft accidents; aircraft mishaps; rotary-wing; helicopter AB GAYDOS SJ, HARRIGAN MJ, BUSHBY AJR. Ten years of spatial disorientation in U.S. Army rotary-wing operations. Aviat Space Environ Med 2012; 83:739-45. Introduction: Spatial disorientation (SD) has plagued aviation since its inception, contributing to numerous lost lives, destroyed or damaged aircraft, and a reduction in operational mission effectiveness. Military rotary-wing (RW) operations are not immune. The U.S. Army has retired many "legacy aircraft" represented in older studies, developed new training regimens for aircrew, continued to expand its night vision capabilities, and has prosecuted combat operations for some 10 yr utilizing new tactics, techniques, and procedures. For these reasons, it is important and relevant to re-engage the subject of SD among accidents within the Army's RW community. Methods: The U.S. Army's Combat Readiness/Safety Center database at Fort Rucker, AL, was queried for the previous 10 yr RW mishaps from fiscal year (FY) 2002 through FY 2011 (FY11 current through 01 July). Accidents identified as having SD as a contributing factor were selected. Results: From FY 2002 to FY 2011, there were 100 Class A through C rotary-wing flight mishaps involving SD. This represents 11% of all Class A through C rotary-wing flight accidents for this period. Of the 100 SD-related accidents, 22% involved fatalities, and 39% involved fatalities and/or injuries. The total number of RW SD-related accidents with fatalities represents 31% of the total helicopter accidents with fatalities for the 10-yr period. Discussion: This review of accident data confirms that SD remains a substantial issue for the Army aviation community and reinforces the importance and relevance of SD awareness, research, education, and training in RW operations. C1 [Gaydos, Steven J.] USA, Aeromed Res Lab, Ft Rucker, AL 36362 USA. [Gaydos, Steven J.; Harrigan, Michael J.; Bushby, Alastair J. R.] Headquarters Army Air Corps, Army Aviat Ctr, Stockbridge, Hants, England. RP Gaydos, SJ (reprint author), USA, Aeromed Res Lab, 6901 Farrel Rd, Ft Rucker, AL 36362 USA. EM steven.j.gaydos@us.army.mil NR 24 TC 3 Z9 3 U1 2 U2 14 PU AEROSPACE MEDICAL ASSOC PI ALEXANDRIA PA 320 S HENRY ST, ALEXANDRIA, VA 22314-3579 USA SN 0095-6562 J9 AVIAT SPACE ENVIR MD JI Aviat. Space Environ. Med. PD AUG PY 2012 VL 83 IS 8 BP 739 EP 745 DI 10.3357/ASEM.3196.2012 PG 7 WC Public, Environmental & Occupational Health; Medicine, General & Internal; Sport Sciences SC Public, Environmental & Occupational Health; General & Internal Medicine; Sport Sciences GA 981AC UT WOS:000306936600001 PM 22872986 ER PT J AU Harrison, SA Hamzeh, FM Han, J Pandya, PK Sheikh, MY Vierling, JM AF Harrison, Stephen A. Hamzeh, Fayez M. Han, Jian Pandya, Prashant K. Sheikh, Muhammed Y. Vierling, John M. TI Chronic hepatitis C genotype 1 patients with insulin resistance treated with pioglitazone and peginterferon alpha-2a plus ribavirin SO HEPATOLOGY LA English DT Article ID VIRUS CORE PROTEIN; VIROLOGICAL RESPONSE; VIRAL LOAD; PEGYLATED INTERFERON; RECEPTOR SUBSTRATE-1; COMBINATION THERAPY; DIABETES-MELLITUS; HIGH PREVALENCE; CELL FUNCTION; NS5A PROTEIN AB Patients with chronic hepatitis C and insulin resistance are less likely to respond to anti-hepatitis C virus (HCV) therapy and are at risk for more rapid fibrosis progression. Coadministration of pioglitazone with peginterferon/ribavirin improves insulin sensitivity and increases virologic response rates in insulin-resistant HCV genotype 4 patients, but it is unclear whether this finding applies to genotype 1 patients. For this reason we randomized treatment-naive HCV genotype 1 patients with insulin resistance to receive either standard care (peginterferon alpha-2a plus ribavirin for 48 weeks, n = 73) or pioglitazone 30-45 mg/day plus standard care (n = 77) in an open-label multicenter trial. Patients randomized to pioglitazone received the drug during a 16-week run-in phase, the 48-week standard-care phase, and the 24-week untreated follow-up phase. Pioglitazone treatment improved hemoglobin A1c (HbA1c), plasma glucose, insulin levels, and homeostasis model assessment of insulin resistance score and increased serum adiponectin levels during the 16-week run-in phase and maintained these improvements during the standard-care phase. However, we observed no statistically significant difference between the two groups in the primary efficacy endpoint, the decrease from baseline to Week 12 of peginterferon alpha-2a/ribavirin treatment in mean log10 HCV RNA titer (-3.5 +/- 1.71 and -3.7 +/- 1.62 IU/mL in the pioglitazone and standard-care groups, respectively, triangle = 0.21 IU/mL, P = 0.4394). Conclusion: Treatment with pioglitazone before and during treatment with peginterferon alpha-2a plus ribavirin improved several indices of glycemic control in patients with chronic hepatitis C and insulin resistance, but did not improve virologic response rates compared with peginterferon alpha-2a plus ribavirin alone. (HEPATOLOGY 2012) C1 [Harrison, Stephen A.] Brooke Army Med Ctr, Dept Med, Div Gastroenterol & Hepatol, Ft Sam Houston, TX 78234 USA. [Hamzeh, Fayez M.; Han, Jian] Genentech Inc, San Francisco, CA 94080 USA. [Pandya, Prashant K.] Univ Kansas, Sch Med, Kansas City VA Med Ctr, Kansas City, MO USA. [Sheikh, Muhammed Y.] Univ Calif San Francisco, Fresno, CA USA. [Vierling, John M.] Baylor Coll Med, Houston, TX 77030 USA. RP Harrison, SA (reprint author), Brooke Army Med Ctr, Dept Med, Div Gastroenterol & Hepatol, 3551 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM STEPHEN.A.HARRISON@us.army.mil FU Merck; Abbott; Bristol-Myers Squibb; Excalenz; Gilead; GlobeImmune; Hyperion; Roche; Sundise; Ocera; Vertex; Conatus; Idenix-Novartis; Ikara; Intercept; Mochida; Novartis; Pfizer; Pharmasset; Zymogenetics FX Dr. Harrison advises and is on the speakers' bureau of Merck. He is also on the speakers' bureau of Bristol-Myers Squibb. Dr. Pandya advises and is on the speakers' bureau of Onyx. He is on the speakers' bureau of Vertex and received grants from Merck. Dr. Vierling advises, consults for, and received grants from Abbott, Bristol-Myers Squibb, Excalenz, Gilead, GlobeImmune, Hyperion, Roche, Merck, Sundise, Ocera, and Vertex. He advises and consults for Salix, HepaLife Tehcnologies, Herbalife, and Ocera. He received grants from Conatus, Idenix-Novartis, Ikara, Intercept, Mochida, Novartis, Pfizer, Pharmasset, and Zymogenetics. Dr. Sheikh is on the speakers' bureau of Merck and Salix. He received grants from Roche and Vertex. NR 42 TC 32 Z9 32 U1 0 U2 3 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0270-9139 J9 HEPATOLOGY JI Hepatology PD AUG PY 2012 VL 56 IS 2 BP 464 EP 473 DI 10.1002/hep.25661 PG 10 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 979GF UT WOS:000306804500009 PM 22334369 ER PT J AU Jagodzinski, LL Weston, HR Liu, Y O'Connell, RJ Peel, SA AF Jagodzinski, Linda L. Weston, Holly R. Liu, Ying O'Connell, Robert J. Peel, Sheila A. TI Efficient Quantification of HIV-1 in Heparin Plasma Spiked with Cultured HIV-1 by the Roche Cobas TaqMan and Abbott RealTime HIV-1 Tests SO JOURNAL OF CLINICAL MICROBIOLOGY LA English DT Article ID ACTIVE ANTIRETROVIRAL THERAPY; AFRICAN-AMERICANS; RNA; AMPLIFICATION; QUANTITATION; INHIBITION; PCR AB The current automated real-time HIV-1 viral load assays, the Roche Cobas AmpliPrep/Cobas TaqMan test and the Abbott Real-Time test, are FDA cleared for use with EDTA plasma. We show that both real-time reverse transcription-PCR (RT-PCR) tests reliably quantify HIV-1 RNA in heparin plasma specimens spiked with HIV-1 isolate MN. C1 [Jagodzinski, Linda L.; O'Connell, Robert J.; Peel, Sheila A.] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD USA. [Weston, Holly R.; Liu, Ying] Henry M Jackson Fdn, US Mil HIV Res Program, Rockville, MD USA. RP Jagodzinski, LL (reprint author), Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD USA. EM ljagodzinski@hivresearch.org FU U.S. Army Medical Research and Materiel Command [W81XWH-072-0067]; Henry M. Jackson Foundation for the Advancement of Military Research [W81XWH-072-0067]; U.S. Army Medical Command FX This work was performed under Cooperative Agreement W81XWH-072-0067 between the U.S. Army Medical Research and Materiel Command and the Henry M. Jackson Foundation for the Advancement of Military Research and executed using funding provided by the U.S. Army Medical Command. We have no conflicts of interest. NR 16 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0095-1137 J9 J CLIN MICROBIOL JI J. Clin. Microbiol. PD AUG PY 2012 VL 50 IS 8 BP 2804 EP 2806 DI 10.1128/JCM.00706-12 PG 3 WC Microbiology SC Microbiology GA 986WY UT WOS:000307378400046 PM 22675128 ER PT J AU dela Cruz, WP Calvano, TP Griffith, ME White, CE Kim, SH Sutton, DA Thompson, EH Fu, JM Wickes, BL Guarro, J Hospenthal, DR AF dela Cruz, Wilfred P. Calvano, Tatjana P. Griffith, Matthew E. White, Christopher E. Kim, Seung H. Sutton, Deanna A. Thompson, Elizabeth H. Fu, Jianmin Wickes, Brian L. Guarro, Josep Hospenthal, Duane R. TI Invasive Apophysomyces variabilis Infection in a Burn Patient SO JOURNAL OF CLINICAL MICROBIOLOGY LA English DT Article ID SOFT-TISSUE; ELEGANS; OSTEOMYELITIS; POSACONAZOLE; SPECIMENS AB Apophysomyces variabilis is an emerging fungal pathogen that can cause significant infections in immunocompetent patients. We report a case of A. variabilis invasive wound infection in a 21-year-old male after a self-inflicted burn injury. C1 [dela Cruz, Wilfred P.; Calvano, Tatjana P.; Griffith, Matthew E.; Hospenthal, Duane R.] San Antonio Mil Med Ctr, Dept Med, Ft Sam Houston, TX USA. [White, Christopher E.; Kim, Seung H.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Sutton, Deanna A.; Thompson, Elizabeth H.] Univ Texas Hlth Sci Ctr San Antonio, Fungus Testing Lab, Dept Pathol, San Antonio, TX 78229 USA. [Fu, Jianmin; Wickes, Brian L.] Univ Texas Hlth Sci Ctr San Antonio, Dept Microbiol, San Antonio, TX 78229 USA. [Guarro, Josep] Univ Rovira & Virgili, Mycol Unit, Sch Med, E-43201 Reus, Spain. [Guarro, Josep] Univ Rovira & Virgili, IISPV, E-43201 Reus, Spain. RP Hospenthal, DR (reprint author), San Antonio Mil Med Ctr, Dept Med, Ft Sam Houston, TX USA. EM drhospenthal@gmail.com OI Delacruz, Wilfred/0000-0001-5363-6975; Guarro, Josep/0000-0002-7839-7568 NR 20 TC 5 Z9 5 U1 2 U2 3 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0095-1137 J9 J CLIN MICROBIOL JI J. Clin. Microbiol. PD AUG PY 2012 VL 50 IS 8 BP 2814 EP 2817 DI 10.1128/JCM.00671-12 PG 4 WC Microbiology SC Microbiology GA 986WY UT WOS:000307378400049 PM 22622444 ER PT J AU Ter-Gabrielyan, N Fromzel, V Ryba-Romanowski, W Lukasiewicz, T Dubinskii, M AF Ter-Gabrielyan, Nikolay Fromzel, Viktor Ryba-Romanowski, Witold Lukasiewicz, Tadeusz Dubinskii, Mark TI Spectroscopic and laser properties of resonantly (in-band) pumped Er:YVO4 and Er:GdVO4 crystals: a comparative study SO OPTICAL MATERIALS EXPRESS LA English DT Article ID THERMAL-CONDUCTIVITY; OPTICAL SPECTROSCOPY; ER3+/YVO4 LASER; EXPANSION; YVO4; ND; COEFFICIENTS; ABSORPTION; VANADATE; INDEX AB We compared spectroscopic properties and resonantly (in-band) pumped laser performances of Er3+:YVO4 and Er3+:GdVO4 single crystals, at room and cryogenic temperatures. It was shown that these gain materials are very similar in absorption and emission spectra, associated with transitions between I-4(15/2) and I-4(13/2) manifolds of Er3+ ions. Both lasers demonstrated comparable performances in quasi continuous wave (QCW) operation at both temperatures. However, Er3+:GdVO4 material performed better in a continuous wave (CW) mode, under the higher thermal load. (C)2012 Optical Society of America C1 [Ter-Gabrielyan, Nikolay; Fromzel, Viktor; Dubinskii, Mark] USA, Res Lab, Adelphi, MD 20783 USA. [Ryba-Romanowski, Witold] Inst Low Temperatures & Struct Res, PL-50422 Wroclaw, Poland. [Lukasiewicz, Tadeusz] Inst Elect Mat Technol, PL-01919 Warsaw, Poland. RP Ter-Gabrielyan, N (reprint author), USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM mark.dubinskiy@us.army.mil NR 24 TC 11 Z9 11 U1 3 U2 23 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 2159-3930 J9 OPT MATER EXPRESS JI Opt. Mater. Express PD AUG 1 PY 2012 VL 2 IS 8 BP 1040 EP 1049 PG 10 WC Materials Science, Multidisciplinary; Optics SC Materials Science; Optics GA 983KG UT WOS:000307117600007 ER PT J AU Cardellina, JH Roxas-Duncan, VI Montgomery, V Eccard, V Campbell, Y Hu, X Tawa, GJ Khavrutskii, I Wallqvist, A Gloer, JB Phatak, NL Holler, U Soman, AG Joshi, BK Hein, SM Wicklow, DT Smith, LA AF Cardellina, J. H., II Roxas-Duncan, V., I Montgomery, V Eccard, V Campbell, Y. Hu, X. Tawa, G. J. Khavrutskii, I Wallqvist, A. Gloer, J. B. Phatak, N. L. Hoeller, U. Soman, A. G. Joshi, B. K. Hein, S. M. Wicklow, D. T. Smith, L. A. TI Fungal BIS-Naphthopyrones as inhibitors of botulinum neurotoxin serotype A SO PLANTA MEDICA LA English DT Meeting Abstract CT International Congress on Natural Products Research on Global Change, Natural Products and Human Health/8th Joint Meeting of AFERP, ASP, GA, PSE and SIF CY JUL 28-AUG 01, 2012 CL New York, NY SP Amer Soc Pharmacognosy (ASP), Soc Med Plant & Nat Prod Res (GA), Italian Soc Phytochem (SIF), Phytochem Soc Europe (PSE), French Speaking Soc Pharmacognosy (AFERP) C1 [Cardellina, J. H., II; Roxas-Duncan, V., I; Montgomery, V; Eccard, V; Campbell, Y.] USA, Div Integrated Toxicol, Med Res Inst Infect Dis, Frederick, MD USA. [Hu, X.; Tawa, G. J.; Khavrutskii, I; Wallqvist, A.] USA, Biotechnol High Performance Comp Software Applica, Telemed & Adv Technol Res Ctr, Med Res & Mat Command, Frederick, MD USA. [Gloer, J. B.; Phatak, N. L.; Hoeller, U.; Soman, A. G.; Joshi, B. K.; Hein, S. M.] Univ Iowa, Dept Chem, Iowa City, IA 52242 USA. [Wicklow, D. T.] ARS, Bacterial Foodborne Pathogens & Mycol Res Unit, USDA, Peoria, IL USA. NR 0 TC 0 Z9 0 U1 0 U2 4 PU GEORG THIEME VERLAG KG PI STUTTGART PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY SN 0032-0943 J9 PLANTA MED JI Planta Med. PD AUG PY 2012 VL 78 IS 11 BP 1044 EP 1045 PG 2 WC Plant Sciences; Chemistry, Medicinal; Integrative & Complementary Medicine; Pharmacology & Pharmacy SC Plant Sciences; Pharmacology & Pharmacy; Integrative & Complementary Medicine GA 982KT UT WOS:000307042800052 ER PT J AU Darwish, AM Bayba, AJ Khorshid, A Rajaie, A Hung, HA AF Darwish, Ali M. Bayba, Andrew J. Khorshid, Ahmed Rajaie, Ahmed Hung, H. Alfred TI Calculation of the Nonlinear Junction Temperature for Semiconductor Devices Using Linear Temperature Values SO IEEE TRANSACTIONS ON ELECTRON DEVICES LA English DT Article DE GaAs heterojunction bipolar transistor (HBT); GaAs pHEMT; gallium nitride (GaN); HEMT; monolithic microwave integrated circuit (MMIC); nonlinear thermal conductivity; reliability; thermal resistance ID THERMAL-RESISTANCE CALCULATION; ALGAN-GAN DEVICES; CONDUCTIVITY; CRYSTALS; PROBE; FILMS AB The drive for smaller, faster, and higher output power integrated circuits continues to push the device junction (channel) temperature to higher levels. An accurate estimate of the maximum junction temperature is necessary for ensuring proper and reliable operation. In most cases, for simplicity, the thermal resistance within the device is calculated or measured assuming constant thermal conductivity, i.e., k. This consistently underestimates the junction temperature. Typically, the maximum temperature is calculated using the expression T-m = To + Delta T-lin, where T-o is the base-plate temperature, and Delta T-lin is the linear temperature rise. This paper derives a new expression, i.e., T-m = T-o exp(Delta T-lin/T-o), replacing the common expression. It is shown that this new expression, which is reported for the first time, accounts for most of the resultant effect due to the nonlinearity of k, converges to the common expression for small Delta T-lin, and is independent of the semiconductor material used in the device. Hence, an improved assessment of the junction temperature can be established even in cases where the temperature dependence of k is not known. The expression's validity is verified by comparing its results with those from finite-element simulations and experimental observations from GaAs heterojunction bipolar transistors and GaN HEMTs. C1 [Darwish, Ali M.; Bayba, Andrew J.; Hung, H. Alfred] USA, Res Lab, Adelphi, MD 20783 USA. [Khorshid, Ahmed; Rajaie, Ahmed] Amer Univ Cairo, Dept Elect Engn, New Cairo 11835, Egypt. RP Darwish, AM (reprint author), USA, Res Lab, Adelphi, MD 20783 USA. EM darwish@alum.mit.edu NR 24 TC 8 Z9 9 U1 2 U2 18 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0018-9383 J9 IEEE T ELECTRON DEV JI IEEE Trans. Electron Devices PD AUG PY 2012 VL 59 IS 8 BP 2123 EP 2128 DI 10.1109/TED.2012.2200040 PG 6 WC Engineering, Electrical & Electronic; Physics, Applied SC Engineering; Physics GA 980UT UT WOS:000306920200018 ER PT J AU Harris, KD Deyle, GD Bui-Mansfield, LT AF Harris, Kevin D. Deyle, Gail D. Bui-Mansfield, Liem T. TI Disruption of a Patellar Tendon Repair SO JOURNAL OF ORTHOPAEDIC & SPORTS PHYSICAL THERAPY LA English DT Editorial Material C1 [Harris, Kevin D.; Deyle, Gail D.] Brooke Army Med Ctr, Phys Therapy Serv, Ft Sam Houston, TX 78234 USA. [Bui-Mansfield, Liem T.] Brooke Army Med Ctr, Dept Radiol, Ft Sam Houston, TX 78234 USA. [Deyle, Gail D.] Army Baylor Univ, Ft Sam Houston, TX USA. RP Harris, KD (reprint author), Brooke Army Med Ctr, Phys Therapy Serv, Ft Sam Houston, TX 78234 USA. NR 1 TC 1 Z9 1 U1 1 U2 2 PU J O S P T, PI ALEXANDRIA PA 1111 NORTH FAIRFAX ST, STE 100, ALEXANDRIA, VA 22314-1436 USA SN 0190-6011 J9 J ORTHOP SPORT PHYS JI J. Orthop. Sports Phys. Ther. PD AUG PY 2012 VL 42 IS 8 BP 738 EP 738 DI 10.2519/jospt.2012.0414 PG 1 WC Orthopedics; Rehabilitation; Sport Sciences SC Orthopedics; Rehabilitation; Sport Sciences GA 981AU UT WOS:000306938500009 PM 22951316 ER PT J AU Delaney, HM Rooks, VJ Wolfe, SQ Sawyer, TL AF Delaney, H. M. Rooks, V. J. Wolfe, S. Q. Sawyer, T. L. TI Term neonate with intracranial hemorrhage and hereditary hemorrhagic telangiectasia: a case report and review of the literature SO JOURNAL OF PERINATOLOGY LA English DT Review DE arteriovenous malformations; endoglin gene; hereditary hemorrhagic telangiectasia ID WEBER-RENDU-SYNDROME; ARTERIOVENOUS-MALFORMATIONS; CHILDREN AB Hereditary hemorrhagic telangiectasia (HHT) is an autosomal dominant disorder characterized by mucocutaneous telangiectases and arteriovenous malformations (AVMs). The disease rarely presents in the neonatal period, primarily manifesting with epistaxis and gastrointestinal bleeding in adulthood. Occasionally, HHT can also present with symptoms related to AVMs in the cerebral, pulmonary or gastrointestinal vasculature. In prior reports, intracranial hemorrhage (ICH) secondary to cerebral AVM in neonates with HHT has been catastrophic and uniformly fatal. Here we report a case of a newborn with HHT and ICH from a suspected AVM who survived with aggressive medical management and surgical intervention, and provide a comprehensive review of the literature on ICH in neonates with HHT. Journal of Perinatology (2012) 32, 642-644; doi: 10.1038/jp.2011.146 C1 [Delaney, H. M.; Sawyer, T. L.] Tripler Army Med Ctr, Dept Pediat, Honolulu, HI 96859 USA. [Rooks, V. J.] Tripler Army Med Ctr, Dept Radiol, Honolulu, HI 96859 USA. [Wolfe, S. Q.] Tripler Army Med Ctr, Dept Neurosurg, Honolulu, HI 96859 USA. RP Delaney, HM (reprint author), Tripler Army Med Ctr, Dept Neonatol, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM heather.delaney@amedd.army.mil NR 10 TC 3 Z9 3 U1 0 U2 3 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 0743-8346 J9 J PERINATOL JI J. Perinatol. PD AUG PY 2012 VL 32 IS 8 BP 642 EP 644 DI 10.1038/jp.2011.146 PG 3 WC Obstetrics & Gynecology; Pediatrics SC Obstetrics & Gynecology; Pediatrics GA 982BB UT WOS:000307015600015 PM 22842803 ER PT J AU Rubal, BJ McKay, K Armstrong, KR Rubal, MP Marbach, MJ AF Rubal, Bernard J. McKay, Kathleen Armstrong, Kevin R. Rubal, Mark P. Marbach, Melissa J. TI Variability in intraosseous pressure induced by saline flush of an intraosseous cannula by multiple practitioners SO LAB ANIMAL LA English DT Article ID FAT-EMBOLISM; VASCULAR ACCESS; INFUSION RATES; BONE-MARROW AB Intraosseous cannulation is an accepted means to achieve vascular access when peripheral venous access is not available. It is common practice to flush the intraosseous cannula with saline prior to establishing infusions. The objective of this study was to evaluate changes in intraosseous pressure during the flush procedure and to assess the variability of pressure changes induced by different practitioners. Two intraosseous cannulas were placed in an isolated cadaveric femur collected from a swine. Intraosseous pressure and the rate of change in pressure were recorded continuously during a series of saline flushes into a distal femoral intraosseous cannula by 21 members of the veterinary research staff at the authors' institution. Median peak intraosseous pressures exceeded 600 mmHg, and an inverse relationship was noted between peak intraosseous pressure and the duration of flush. Bone marrow fat emboli were grossly evident in flush effluents and their presence was confirmed by microscopic examination. Until the practitioners were informed of the pressure changes induced by the intraosseous cannula flush, few had appreciated the magnitude of the pressures that they had generated, suggesting that an instrumented intraosseous flush preparation like the one used in this study may prove useful as a training tool for flush procedures. C1 [Rubal, Bernard J.; Rubal, Mark P.; Marbach, Melissa J.] Brooke Army Med Ctr, San Antonio, TX USA. [McKay, Kathleen; Armstrong, Kevin R.] USA, Inst Surg Res, San Antonio, TX USA. RP Rubal, BJ (reprint author), Brooke Army Med Ctr, San Antonio, TX USA. EM bernard.j.rubal@us.army.mil FU Advanced Medical Technology Initiative [AAMTI-1574] FX We thank the veterinarians, veterinary technicians and senior research staff at the US Army Institute of Surgical Research for their participation and support of this project. Funding for this project was in part provided by Advanced Medical Technology Initiative (AAMTI-1574). The content of this manuscript was presented at the 62nd AALAS National Meeting (2011) in San Diego, CA. The views expressed in this commentary are those of the authors and do not reflect the official policy or position of the Department of the Army, Department of Defense, or the US Government. NR 36 TC 4 Z9 4 U1 0 U2 1 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 0093-7355 J9 LAB ANIMAL JI Lab Anim. PD AUG PY 2012 VL 41 IS 8 BP 224 EP 229 PG 6 WC Veterinary Sciences SC Veterinary Sciences GA 982GN UT WOS:000307031100017 PM 22821045 ER PT J AU Waterman, P Kwak, Y Clifford, R Julius, M Onmus-Leone, F Tsurgeon, C Riley, M Black, C McGann, P Lesho, E AF Waterman, Paige Kwak, Yoon Clifford, Robert Julius, Michael Onmus-Leone, Fatma Tsurgeon, Cyruss Riley, Matthew Black, Chad McGann, Patrick Lesho, Emil TI A multidrug-resistance surveillance network: 1 year on SO LANCET INFECTIOUS DISEASES LA English DT Letter C1 [Waterman, Paige; Kwak, Yoon; Clifford, Robert; Julius, Michael; Onmus-Leone, Fatma; Tsurgeon, Cyruss; Riley, Matthew; Black, Chad; McGann, Patrick; Lesho, Emil] Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. RP Waterman, P (reprint author), Walter Reed Army Inst Res, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM carolinelesho@yahoo.com RI Black, Chad/B-2848-2011 NR 5 TC 8 Z9 8 U1 0 U2 1 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1473-3099 EI 1474-4457 J9 LANCET INFECT DIS JI Lancet Infect. Dis. PD AUG PY 2012 VL 12 IS 8 BP 587 EP 588 DI 10.1016/S1473-3099(12)70149-4 PG 2 WC Infectious Diseases SC Infectious Diseases GA 981BT UT WOS:000306941200011 PM 22835896 ER PT J AU Nittrouer, JA Best, JL Brantley, C Cash, RW Czapiga, M Kumar, P Parker, G AF Nittrouer, Jeffrey A. Best, James L. Brantley, Christopher Cash, Ronald W. Czapiga, Matthew Kumar, Praveen Parker, Gary TI Mitigating land loss in coastal Louisiana by controlled diversion of Mississippi River sand SO NATURE GEOSCIENCE LA English DT Article ID SEA-LEVEL RISE; WETLAND LOSS; WATER; DELTA; RESTORATION; LAKE AB After the 1927 flood of record on the Mississippi River, the Bonnet Carre Spillway in Louisiana was constructed as a flood control operation. When it is opened, the spillway diverts floodwaters from the Mississippi River to Lake Pontchartrain(1), to reduce the water discharge flowing past New Orleans. During the 2011 Mississippi River flood, which had the highest peak discharge since 1927, the Bonnet Carre Spillway was opened for 42 days, from 9May to 20 June. During this period, the average spillway discharge of 6,010m(3) s(-1) amounted to 10-20% of the total river flood discharge. Here we present measurements of the areal extent and thickness of new sediments in the floodway, following the 2011 Mississippi flood. Only the upper 10-15% of the river water column was skimmed into the floodway. Yet, we conservatively estimate that 31-46% of the total sand load carried by the Mississippi River during the period of spillway opening was diverted. We find that local river conditions led to increased concentrations of suspended sand in the upper water column and thus led to diversion of sand from the river into the spillway. We conclude that an appropriate design of engineered river diversions in Louisiana can help mitigate coastal wetland loss. C1 [Nittrouer, Jeffrey A.; Best, James L.; Cash, Ronald W.; Parker, Gary] Univ Illinois, Dept Geol, Urbana, IL 61801 USA. [Nittrouer, Jeffrey A.; Best, James L.; Czapiga, Matthew; Kumar, Praveen; Parker, Gary] Univ Illinois, Ven Te Chow Hydrosyst Lab, Dept Civil & Environm Engn, Urbana, IL 61801 USA. [Best, James L.] Univ Illinois, Dept Geog & Geog Informat Sci, Urbana, IL 61801 USA. [Best, James L.] Univ Illinois, Dept Mech Sci & Engn, Urbana, IL 61801 USA. [Brantley, Christopher] USA, Corps Engineers, Norco, LA 70079 USA. RP Nittrouer, JA (reprint author), Univ Illinois, Dept Geol, Urbana, IL 61801 USA. EM jeffnitt@illinois.edu RI Kumar, Praveen/D-2036-2010; Best, Jim/P-8440-2015 OI Kumar, Praveen/0000-0002-4787-0308; Best, Jim/0000-0001-5314-6140 FU National Science Foundation (NSF) [EAR 1140198, EAR 0948224]; Office of Naval Research [N00014-10-1-0617]; National Center for Earth-Surface Dynamics, an NSF Science and Technology Center [EAR 0120914] FX This research was supported by the National Science Foundation (NSF) through the RAPID grant EAR 1140198. J.A.N. was partially supported by NSF post doctoral grant EAR 0948224. M. C. and G. P. were partially supported by the Office of Naval Research, N00014-10-1-0617. G. P. was partially supported by the National Center for Earth-Surface Dynamics, an NSF Science and Technology Center, EAR 0120914. The authors acknowledge T. Sawyer and E. Prokocki for providing valuable field assistance and the sedimentology lab at the Jackson School of Geosciences at the University of Texas, Austin, for facilities support. The logistical support of the United States Geological Survey and the USACE are gratefully acknowledged. NR 26 TC 34 Z9 34 U1 6 U2 90 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 1752-0894 EI 1752-0908 J9 NAT GEOSCI JI Nat. Geosci. PD AUG PY 2012 VL 5 IS 8 BP 534 EP 537 DI 10.1038/NGEO1525 PG 4 WC Geosciences, Multidisciplinary SC Geology GA 983DR UT WOS:000307099000008 ER PT J AU Mathew, SD Battafarano, DF Morris, MJ AF Mathew, Stephanie D. Battafarano, Daniel F. Morris, Michael J. TI Relapsing Polychondritis in the Department of Defense Population and Review of the Literature SO SEMINARS IN ARTHRITIS AND RHEUMATISM LA English DT Review DE Relapsing polychondrities; Polychondrities ID REVERSIBLE AIRWAY-OBSTRUCTION; SUSTAINED RESPONSE; II COLLAGEN; PULMONARY-FUNCTION; CYCLOSPORINE-A; INVOLVEMENT; INFLIXIMAB; MANIFESTATIONS; PATIENT; RECONSTRUCTION AB Objective: The objective of this study was to characterize the clinical features of relapsing polychondritis (RPC) within the Department of Defense beneficiary population and determine the utility of echocardiography, imaging studies, and pulmonary function testing for diagnosis and monitoring disease. Methods: We performed a retrospective Electronic Medical Record chart review of all patients diagnosed with RPC within the Department of Defense between January 2004 and December 2009. Results: Thirty patients met McAdam's diagnostic criteria and an additional 13 met our criteria for partial RPC. Auricular chondritis (88%), inflammatory eye disease (57%), and arthritis (60%) were the most common clinical manifestations. Pulmonary involvement was seen in 16 (37%) patients. Methotrexate (42%) and corticosteroids (21%) were the most conventional therapies. Thirty (70%) patients had pulmonary function tests with flow volume loop abnormalities observed in 33%. Chest computed tomography was performed in 63%, with abnormalities in 48%. Abnormalities on echocardiography were observed in 12 of 25 (48%) patients. Conclusions: The incidence, demographic data, and organ involvement in our RPC patients were similar to previous studies. The diagnosis of RPC was determined primarily on physical examination and symptom-driven diagnostic testing. There was no notable pattern by rheumatologists for monitoring the progression of tracheobronchial tree or large vessel involvement. Interpreting flow volume loops is recommended with pulmonary function testing to detect early laryngotracheal involvement. Computed tomography of the chest is also recommended to monitor for vascular and tracheobronchial tree involvement. Published by Elsevier Inc. Semin Arthritis Rheum 42:70-83 C1 [Mathew, Stephanie D.; Battafarano, Daniel F.] Brooke Army Med Ctr, Rheumatol Serv, Dept Med, Ft Sam Houston, TX 78209 USA. [Morris, Michael J.] Brooke Army Med Ctr, Pulm Dis Serv, Dept Med, Ft Sam Houston, TX 78209 USA. RP Battafarano, DF (reprint author), Brooke Army Med Ctr, Rheumatol Serv, Dept Med, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78209 USA. EM Daniel.Battafarano@amedd.army.mil NR 83 TC 15 Z9 16 U1 0 U2 2 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0049-0172 J9 SEMIN ARTHRITIS RHEU JI Semin. Arthritis Rheum. PD AUG PY 2012 VL 42 IS 1 BP 70 EP 83 DI 10.1016/j.semarthrit.2011.12.007 PG 14 WC Rheumatology SC Rheumatology GA 982GF UT WOS:000307030300009 PM 22417894 ER PT J AU Dalton, SR Chandler, WM Abuzeid, M Hossler, EW Ferringer, T Elston, DM LeBoit, PE AF Dalton, Scott R. Chandler, Wells M. Abuzeid, Margaret Hossler, Eric W. Ferringer, Tammie Elston, Dirk M. LeBoit, Philip E. TI Eosinophils in Mycosis Fungoides: An Uncommon Finding in the Patch and Plaque Stages SO AMERICAN JOURNAL OF DERMATOPATHOLOGY LA English DT Article DE mycosis fungoides; CTCL; eosinophils; patch; plaque; histopathology ID T-CELL LYMPHOMA; SEZARY-SYNDROME; DIAGNOSIS AB Early diagnosis of mycosis fungoides (MF) is one of the most challenging problems in dermatopathology, as the histopathologic features of inflammatory dermatoses and MF may show significant overlap. One criterion used to distinguish early MF (patch stage) from dermatitis, which may be currently underutilized, is the presence of eosinophils. A search was performed for cases with a preoperative diagnosis of MF, cutaneous T-cell lymphoma, or dermatitis, which included 29 cases "diagnostic" for MF, 25 cases "suspicious" for MF, and 55 cases of spongiotic dermatitis. We examined tissue sections blinded to diagnosis to obtain an exact eosinophil count. Twenty-nine cases were diagnostic for MF (12 patch, 9 plaque, and 8 tumor stage). The average eosinophil count for cases diagnostic for patch stage MF was 1 eosinophil in 10 (0.11) sections examined. For plaque MF, there was 1 eosinophil in 5 (0.24) sections examined. All tumor stage MF cases showed abundant eosinophils within each section. Twenty-five cases were suspicious for MF (15 patches, 9 plaques, and 1 folliculotropic). The average eosinophil count for the patch lesions was 1 eosinophil in 4 (0.25) sections examined and 2 eosinophils per section for plaque lesions. Forty-five of 55 cases of spongiotic dermatitis had at least scattered eosinophils (>3) in each section. Twenty-three (47%) had eosinophils around most postcapillary venules. Only 3 of 45 patients (6.6%) with biopsies diagnostic or suspicious for patch or plaque stage MF showed >3 eosinophils per tissue section, whereas 45 of 55 (81.8%) biopsies of spongiotic dermatitis had >3. The presence of eosinophils (>3 per tissue section) is statistically significant in differentiating cases diagnostic or suspicious for patch or plaque stage MF from dermatitis (P < 0.0001). Our data indicate that eosinophils are uncommon in cases of patch and plaque MF. When a pathologist is faced with evaluating a biopsy that lacks some of the criteria used to make the diagnosis of patch stage MF, yet demonstrates >3 eosinophils per tissue section, dermatitis is the likely diagnosis. However, in cases where fewer than 3 eosinophils are present in sections, patch stage MF cannot be excluded. C1 [Dalton, Scott R.; Hossler, Eric W.; Ferringer, Tammie; Elston, Dirk M.] Geisinger Med Ctr, Dept Dermatol, Danville, PA 17821 USA. [Chandler, Wells M.; Hossler, Eric W.; Ferringer, Tammie; Elston, Dirk M.] Geisinger Med Ctr, Dept Pathol, Danville, PA 17821 USA. [Abuzeid, Margaret] Brooke Army Med Ctr, Dept Pathol, Ft Sam Houston, TX 78234 USA. [LeBoit, Philip E.] Univ Calif San Francisco, Dept Pathol, San Francisco, CA 94140 USA. [LeBoit, Philip E.] Univ Calif San Francisco, Dept Dermatol, San Francisco, CA 94140 USA. RP Dalton, SR (reprint author), Geisinger Med Ctr, Dept Dermatol, Danville, PA 17821 USA. EM scott.dalton@us.army.mil NR 15 TC 6 Z9 6 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0193-1091 J9 AM J DERMATOPATH JI Am. J. Dermatopathol. PD AUG PY 2012 VL 34 IS 6 BP 586 EP 591 DI 10.1097/DAD.0b013e31823d921b PG 6 WC Dermatology SC Dermatology GA 977KQ UT WOS:000306659100007 PM 22814317 ER PT J AU Schwartz, MD Hurst, CG Kirk, MA Reedy, SJD Braue, EH AF Schwartz, M. D. Hurst, C. G. Kirk, M. A. Reedy, S. J. D. Braue, E. H., Jr. TI Reactive Skin Decontamination Lotion (RSDL) for the Decontamination of Chemical Warfare Agent (CWA) Dermal Exposure SO CURRENT PHARMACEUTICAL BIOTECHNOLOGY LA English DT Review DE VX; soman; vesicants; sulfur mustard; dermal; decontamination; reactive skin decontamination lotion; chemical warfare ID 1-PERCENT SOAPY WATER; 0.5-PERCENT BLEACH; REDUCTION PASTE; DOMESTIC SWINE; VX; EFFICACY; KIT AB Rapid decontamination of the skin is the single most important action to prevent dermal absorption of chemical contaminants in persons exposed to chemical warfare agents (CWA) and toxic industrial chemicals (TICs) as a result of accidental or intentional release. Chemicals on the skin may be removed by mechanical means through the use of dry sorbents or water. Recent interest in decontamination systems which both partition contaminants away from the skin and actively neutralize the chemical has led to the development of several reactive decontamination solutions. This article will review the recently FDA-approved Reactive Skin Decontamination Lotion (RSDL) and will summarize the toxicity and efficacy studies conducted to date. Evidence of RSDL's superior performance against vesicant and organophosphorus chemical warfare agents compared to water, bleach, and dry sorbents, suggests that RSDL may have a role in mass human exposure chemical decontamination in both the military and civilian arenas. C1 [Schwartz, M. D.] CDC, Off Terrorism Preparedness & Emergency Response, Natl Ctr Environm Hlth, Atlanta, GA 30333 USA. [Hurst, C. G.; Braue, E. H., Jr.] USA, Med Res Inst Chem Def, Washington, DC USA. [Kirk, M. A.] Univ Virginia, Dept Emergency Med, Off Hlth Affairs, Dept Homeland Secur, Charlottesville, VA 22903 USA. RP Schwartz, MD (reprint author), CDC, Off Terrorism Preparedness & Emergency Response, Natl Ctr Environm Hlth, 1600 Clifton Rd,Mailstop F-09, Atlanta, GA 30333 USA. EM Aeo8@cdc.gov NR 20 TC 7 Z9 11 U1 4 U2 41 PU BENTHAM SCIENCE PUBL LTD PI SHARJAH PA EXECUTIVE STE Y26, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB EMIRATES SN 1389-2010 J9 CURR PHARM BIOTECHNO JI Curr. Pharm. Biotechnol. PD AUG PY 2012 VL 13 IS 10 BP 1971 EP 1979 PG 9 WC Biochemistry & Molecular Biology; Pharmacology & Pharmacy SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy GA 979QP UT WOS:000306835200015 PM 22352732 ER PT J AU Levy, G Hill, MJ Ramirez, CI Correa, L Ryan, ME DeCherney, AH Levens, ED Whitcomb, BW AF Levy, Gary Hill, Micah J. Ramirez, Christina I. Correa, Luiz Ryan, Mary E. DeCherney, Alan H. Levens, Eric D. Whitcomb, Brian W. TI The use of follicle flushing during oocyte retrieval in assisted reproductive technologies: a systematic review and meta-analysis SO HUMAN REPRODUCTION LA English DT Review DE follicle flushing; oocyte retrieval; in-vitro fertilization; assisted reproductive technologies ID FERTILIZATION PROGRAM; INVITRO FERTILIZATION; CONTROLLED-TRIALS; RANDOMIZED-TRIAL; ASPIRATION; RECOVERY; STIMULATION; QUALITY; NEEDLES; IVF AB Does follicular flushing during assisted reproductive technologies (ART) improve the number of oocytes retrieved? Follicular flushing during ART does not result in a greater number of oocytes in normal responders. Despite limited evidence supporting the use of follicular flushing, it continues to be a common procedure in many ART clinics. Prior studies have provided conflicting results regarding the routine use of flushing during oocyte retrieval. Systematic review and meta-analysis of 518 patients who participated in 6 randomized trials over 20 years. Literature searches were conducted to retrieve randomized controlled trials on follicle or ovarian flushing in ART. Databases searched included PubMed, EMBASE, Web of Science and the Cochrane Database of Clinical Trials (CENTRAL). Six trials that included 518 subjects matched the inclusion criteria. Studies included were limited to trials that were published, randomized trials comparing oocyte retrieval with a single-lumen pick-up needle versus follicle flushing after direct aspiration with a multi-channel oocyte pick-up needle in ART patients. In each of the trials, measures of the oocyte yield (oocytes retrieved divided by follicles aspirated), total oocytes retrieved, fertilization or pregnancy were not different when comparing direct aspiration with follicle flushing. Four trials reported a higher operative time with follicle flushing. Results of the meta-analysis indicated no significant differences in the oocytes retrieved [weighted mean difference: 0.07, 95 confidence interval (CI): 0.13 to 0.29] or the oocyte yield (odds ratio: 1.06, 95 CI: 0.951.18) between the non-flushing and flushing groups. All trials featured an open label design and the majority of patients in this meta-analysis were normal responders. The applications of these results to poor responders, patients undergoing natural cycle ART or minimal stimulation ART should be made with caution. Follicle flushing does not improve ART outcomes in normal-responding patients and should not be performed. This meta-analysis should solidify this recommendation as it includes the largest trial published on the subject and is consistent with a recently published Cochrane review. This work was supported, in part, by the Program in Reproductive and Adult Endocrinology, NICHD, NIH, Bethesda, MD. The authors have no competing interests to declare. N/A. C1 [Whitcomb, Brian W.] Univ Massachusetts, Div Biostat & Epidemiol, Sch Publ Hlth & Hlth Sci, Amherst, MA 01003 USA. [Levy, Gary; Hill, Micah J.; Ramirez, Christina I.; DeCherney, Alan H.] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Program Reprod & Adult Endocrinol, NIH, Bethesda, MD USA. [Correa, Luiz] Tripler Army Med Ctr, Honolulu, HI 96859 USA. [Ryan, Mary E.] Natl Inst Hlth Lib, Bethesda, MD USA. [Levens, Eric D.] Shady Grove Fertil Ctr, Bethesda, MD USA. RP Whitcomb, BW (reprint author), Univ Massachusetts, Div Biostat & Epidemiol, Sch Publ Hlth & Hlth Sci, 408 Arnold House,715 N Pleasant St, Amherst, MA 01003 USA. EM bwhitcomb@schoolph.umass.edu FU NICHD, NIH, Bethesda, MD FX This work was supported, in part, by the Program in Reproductive and Adult Endocrinology, NICHD, NIH, Bethesda, MD. NR 24 TC 10 Z9 10 U1 0 U2 3 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 0268-1161 J9 HUM REPROD JI Hum. Reprod. PD AUG PY 2012 VL 27 IS 8 BP 2373 EP 2379 DI 10.1093/humrep/des174 PG 7 WC Obstetrics & Gynecology; Reproductive Biology SC Obstetrics & Gynecology; Reproductive Biology GA 977HZ UT WOS:000306648600015 PM 22647450 ER PT J AU Cavalieri, DJ Markus, T Ivanoff, A Miller, JA Brucker, L Sturm, M Maslanik, JA Heinrichs, JF Gasiewski, AJ Leuschen, C Krabill, W Sonntag, J AF Cavalieri, Donald J. Markus, Thorsten Ivanoff, Alvaro Miller, Jeff A. Brucker, Ludovic Sturm, Matthew Maslanik, James A. Heinrichs, John F. Gasiewski, Albin J. Leuschen, Carl Krabill, William Sonntag, John TI A Comparison of Snow Depth on Sea Ice Retrievals Using Airborne Altimeters and an AMSR-E Simulator SO IEEE TRANSACTIONS ON GEOSCIENCE AND REMOTE SENSING LA English DT Article DE Airborne altimetry; passive microwave remote sensing; sea ice; snow on sea ice ID MICROWAVE SIGNATURES; LASER ALTIMETRY; RADAR ALTIMETER; ROUGHNESS; ACCURACY; SYSTEM; SHEET AB A comparison of snow depths on sea ice was made using airborne altimeters and an Advanced Microwave Scanning Radiometer for the Earth Observing System (AMSR-E) simulator. The data were collected during the March 2006 National Aeronautics and Space Administration (NASA) Arctic field campaign utilizing the NASA P-3B aircraft. The campaign consisted of an initial series of coordinated surface and aircraft measurements over Elson Lagoon, Alaska and adjacent seas followed by a series of large-scale (100 km x 50 km) coordinated aircraft and AMSR-E snow depth measurements over portions of the Chukchi and Beaufort seas. This paper focuses on the latter part of the campaign. The P-3B aircraft carried the University of Colorado Polarimetric Scanning Radiometer (PSR-A), the NASA Wallops Airborne Topographic Mapper (ATM) lidar altimeter, and the University of Kansas Delay-Doppler (D2P) radar altimeter. The PSR-A was used as an AMSR-E simulator, whereas the ATM and D2P altimeters were used in combination to provide an independent estimate of snow depth. Results of a comparison between the altimeter-derived snow depths and the equivalent AMSR-E snow depths using PSR-A brightness temperatures calibrated relative to AMSR-E are presented. Data collected over a frozen coastal polynya were used to intercalibrate the ATM and D2P altimeters before estimating an altimeter snow depth. Results show that the mean difference between the PSR and altimeter snow depths is -2.4 cm (PSR minus altimeter) with a standard deviation of 7.7 cm. The RMS difference is 8.0 cm. The overall correlation between the two snow depth data sets is 0.59. C1 [Cavalieri, Donald J.; Markus, Thorsten; Ivanoff, Alvaro; Miller, Jeff A.; Brucker, Ludovic; Krabill, William; Sonntag, John] NASA, Goddard Space Flight Ctr, Cryospher Sci Lab, Greenbelt, MD 20771 USA. [Ivanoff, Alvaro] ADNET Syst Inc, Rockville, MD 20852 USA. [Miller, Jeff A.] Wyle Informat Sci, Mclean, VA 22102 USA. [Brucker, Ludovic] Univ Space Res Assoc, Goddard Earth Sci Technol & Res Studies & Invest, Columbia, MD 21044 USA. [Sturm, Matthew] USA, Cold Reg Res & Engn Lab, Ft Wainwright, AK 99703 USA. [Maslanik, James A.] Univ Colorado, Colorado Ctr Astrodynam Res, Boulder, CO 80262 USA. [Heinrichs, John F.] Ft Hays State Univ, Dept Geosci, Hays, KS 67601 USA. [Gasiewski, Albin J.] Univ Colorado, Dept Elect & Comp Engn, Boulder, CO 80309 USA. [Leuschen, Carl] Univ Kansas, Ctr Remote Sensing Ice Sheets, Lawrence, KS 66045 USA. [Krabill, William] Sigma Space Inc, Wallops Isl, VA 23337 USA. [Sonntag, John] URS Corp, Wallops Isl, VA 23337 USA. RP Cavalieri, DJ (reprint author), NASA, Goddard Space Flight Ctr, Cryospher Sci Lab, Greenbelt, MD 20771 USA. EM Donald.J.Cavalieri@nasa.gov; thorsten.markus@nasa.gov; Alvaro.Ivanoff@nasa.gov; jeff.miller@nasa.gov; ludovic.brucker@nasa.gov; matthew.sturm@usace.army.mil; james.maslanik@colorado.edu; jheinric@fhsu.edu; al.gasiewski@colorado.edu; leuschen@cresis.ku.edu; William.B.Krabill@nasa.gov; john.g.sonntag@nasa.gov RI Brucker, Ludovic/A-8029-2010 OI Brucker, Ludovic/0000-0001-7102-8084 FU NASA EOS Project Office; NASA; National Science Foundation FX The authors thank the NASA EOS Project Office and the NASA Cryospheric Sciences Program for their full support and the NASA P-3B pilots and their crew for meeting all flight objectives, all of which led to the successful completion of the Arctic 2006 field campaign. We also think the two anonymous reviewers whose comments and recommendations have resulted in a significantly improved manuscript.; The authors also acknowledge both the National Space Science and Technology Center in Huntsville, AL and the National Snow and Ice Data Center in Boulder, Colorado for processing and providing the AMSR-E snow depth on sea ice products. The ECMWF data used in this study are from the Research Data Archive (RDA) which is maintained by the Computational and Information Systems Laboratory at the National Center for Atmospheric Research which is sponsored by the National Science Foundation. The original data (data set number ds627.0) are available from the RDA (http://dss.ucar.edu). The AMSR-E sea ice drift gridded products were obtained from the Centre de Recherche et d'Exploitation Satellitaire (CERSAT), at IFREMER, Plouzane, France (http://cersat.ifremer.fr/data/discovery/by_product_type/gridded_product s). NR 22 TC 14 Z9 14 U1 0 U2 20 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0196-2892 J9 IEEE T GEOSCI REMOTE JI IEEE Trans. Geosci. Remote Sensing PD AUG PY 2012 VL 50 IS 8 BP 3027 EP 3040 DI 10.1109/TGRS.2011.2180535 PG 14 WC Geochemistry & Geophysics; Engineering, Electrical & Electronic; Remote Sensing; Imaging Science & Photographic Technology SC Geochemistry & Geophysics; Engineering; Remote Sensing; Imaging Science & Photographic Technology GA 977UV UT WOS:000306691200008 ER PT J AU Moore, NLT Gauchan, S Genovese, RF AF Moore, Nicole L. T. Gauchan, Sangeeta Genovese, Raymond F. TI Differential severity of anxiogenic effects resulting from a brief swim or underwater trauma in adolescent male rats SO PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR LA English DT Article DE Adolescent; Stress; Underwater trauma; Anxiety; Glucocorticoids ID POSTTRAUMATIC-STRESS-DISORDER; ELEVATED PLUS-MAZE; ANXIETY-LIKE BEHAVIOR; CHRONIC MILD STRESS; CHILDHOOD ADVERSITY; RISK-FACTORS; DEPRESSION; EXPOSURE; ADULTS; CONSEQUENCES AB Clinical studies have shown a link between early-life adversity and severity of adulthood responses to a traumatic stress event (post-traumatic stress disorder, PTSD). Despite a need for basic research, few rodent models are available to test the lasting impacts of early-life traumatic stressors. Underwater trauma (UWT) has been used previously to model traumatic stress; however, effects of this procedure have only been characterized in adulthood. Susceptibility of younger animals to physiological or psychological damage from a forced submersion procedure is unknown. A procedure involving swimming may be a stressful stimulus outside of the underwater component of the experience, as well. The acute effects of a 1-minute sham exposure (empty water tank), swim-only, and UWT (40 s swim followed by 20 s underwater) were compared in adolescent rats at postnatal day 37. No effects on blood oxygenation or lung tissue were observed. Stepwise decreases in open arm behavior were observed on the elevated plus maze (EPM) in swim-only rats, while UWT rats showed an immediate, lasting decrease in open arm behavior. UWT rats showed a significant decrease in basal corticosterone one week after trauma. These results show that while water immersion is a stressor. MATT causes a distinct syndrome of traumatic stress response in adolescent rats. (C) 2012 Elsevier Inc. All rights reserved. C1 [Moore, Nicole L. T.; Gauchan, Sangeeta; Genovese, Raymond F.] Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci, Behav Biol Branch, Silver Spring, MD 20910 USA. RP Moore, NLT (reprint author), Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci, Behav Biol Branch, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM nicole.moore@amedd.army.mil FU Military Operational Medicine Research Program, US Army Medical Research and Materiel Command FX This study was supported by the Military Operational Medicine Research Program, US Army Medical Research and Materiel Command. N.L.T.M is a National Research Council Postdoctoral Fellow. NR 32 TC 10 Z9 10 U1 0 U2 1 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0091-3057 J9 PHARMACOL BIOCHEM BE JI Pharmacol. Biochem. Behav. PD AUG PY 2012 VL 102 IS 2 BP 264 EP 268 DI 10.1016/j.pbb.2012.05.002 PG 5 WC Behavioral Sciences; Neurosciences; Pharmacology & Pharmacy SC Behavioral Sciences; Neurosciences & Neurology; Pharmacology & Pharmacy GA 978WH UT WOS:000306776000012 PM 22584043 ER PT J AU Jain, R Yeo, H AF Jain, Rohit Yeo, Hyeonsoo TI Effects of torsion frequencies on rotor performance and structural loads with trailing edge flap SO SMART MATERIALS AND STRUCTURES LA English DT Article ID PREDICTION AB The effects of variation of blade torsion frequency on rotor performance and structural loads are investigated for a 1/rev active flap rotor and baseline rotor (no active control). The UH-60A four-bladed articulated main rotor is studied at a high-speed forward flight condition. The torsion frequencies are varied by modifying the spanwise torsional stiffness of the blade and/or the pitch link stiffness. First, a parametric/optimization study on the flap deployment schedule is carried out using lifting-line comprehensive analysis for the soft, baseline, and stiff rotor configurations, and then a higher fidelity coupled computational fluid dynamics-computational structural dynamics analysis is carried out for the optimal flap deployment. It is shown that with the soft rotor there is degradation in performance-of about 6% with respect to the baseline rotor in the case where the flaps are not activated, and of about 1% if flap deflections are applied. On the other hand, for the stiff rotor there is a slight improvement in performance-of about 2.3% when the flaps are not activated, and no appreciable change in the case where active flap deflections are applied. It appears that the peak performance achievable with using active flaps on a baseline stiffness rotor cannot be further improved significantly by varying the torsional frequencies. Variation of torsion frequency does not appear to have a significant influence on blade torsion moments and pitch link loads, although the 1/rev flap activation examined has an important role. C1 [Jain, Rohit; Yeo, Hyeonsoo] USA, Res Dev & Engn Command, Ames Res Ctr, Aeroflightdynam Directorate AMRDEC, Moffett Field, CA USA. RP Jain, R (reprint author), USA, Res Dev & Engn Command, Ames Res Ctr, Aeroflightdynam Directorate AMRDEC, Moffett Field, CA USA. EM rjain@merlin.arc.nasa.gov FU US Army Research, Development, and Engineering Command (AMRDEC) under SBIR [W911W6-08-C-0061] FX This work was presented at the Future Vertical Lift Aircraft Design Conference, San Francisco, California, January 18-20, 2012. This work was performed while the first author was an employee at HyPerComp Inc. and was sponsored by US Army Research, Development, and Engineering Command (AMRDEC) under SBIR Contract# W911W6-08-C-0061. Technical monitors are Drs Hyeonsoo Yeo and Mark Fulton at the US Army Aeroflightdynamics Directorate (AFDD). This is a work of the US Government and is not subject to copyright protection in the US. NR 27 TC 0 Z9 0 U1 0 U2 2 PU IOP PUBLISHING LTD PI BRISTOL PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND SN 0964-1726 J9 SMART MATER STRUCT JI Smart Mater. Struct. PD AUG PY 2012 VL 21 IS 8 AR 085026 DI 10.1088/0964-1726/21/8/085026 PG 11 WC Instruments & Instrumentation; Materials Science, Multidisciplinary SC Instruments & Instrumentation; Materials Science GA 978BL UT WOS:000306713800027 ER PT J AU Albrecht, MT Eyles, JE Baillie, LW Keane-Myers, AM AF Albrecht, Mark T. Eyles, Jim E. Baillie, Les W. Keane-Myers, Andrea M. TI Immunogenicity and efficacy of an anthrax/plague DNA fusion vaccine in a mouse model SO FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY LA English DT Article DE anthrax; plague; DNA vaccine ID BACILLUS-ANTHRACIS INFECTION; EQUINE ENCEPHALITIS-VIRUS; LETHAL FACTOR; PROTECTIVE ANTIGEN; YERSINIA-PESTIS; PLAGUE VACCINE; MURINE MODEL; IMMUNIZATION; PLASMID; DELIVERY AB The efficacy of multi-agent DNA vaccines consisting of a truncated gene encoding Bacillus anthracis lethal factor (LFn) fused to either Yersinia pestis V antigen (V) or Y . pestis F1 was evaluated. A/J mice were immunized by gene gun and developed predominantly IgG1 responses that were fully protective against a lethal aerosolized B. anthracis spore challenge but required the presence of an additional DNA vaccine expressing anthrax protective antigen to boost survival against aerosolized Y. pestis. C1 [Albrecht, Mark T.; Keane-Myers, Andrea M.] USA, Biol Def Res Directorate, Med Res Ctr, Ft Detrick, MD 21702 USA. [Eyles, Jim E.] DSTL, Porton Down, Wilts, England. [Baillie, Les W.] Cardiff Univ, Sch Pharm & Pharmaceut Sci, Cardiff, S Glam, Wales. [Baillie, Les W.] Univ Maryland, Sch Med, BIOMET, Baltimore, MD 21201 USA. RP Keane-Myers, AM (reprint author), USA, Biol Def Res Directorate, Med Res Ctr, 8400 Res Plaza, Ft Detrick, MD 21702 USA. EM andrea.keane-myers@med.navy.mil OI Baillie, Les/0000-0002-8186-223X FU U.S. Naval Medical Research Center [0000106993]; Henry M. Jackson Foundation for the Advancement of Military medicine [0000106993]; Dstl [0000106993] FX All animal studies were carried out in strict accordance with the Animals (Scientific Procedures) Act 1986. This work was financially supported by contract #0000106993 between the U.S. Naval Medical Research Center, the Henry M. Jackson Foundation for the Advancement of Military medicine, and Dstl. The authors wish to thank G. K. Paterson, A. Gates, A. Stagg, and S. Perkins for critical technical input. The views expressed in this article are those of the authors and do not necessarily reflect the official policy or position of the Department of the Navy, the Department of Defense, nor the U. S. Government. A. K.-M. is an employee of the U. S. Government. This work was prepared as a part of her official duties. Title 17 U. S. C. 105 provides that Copyright protection under this title is not available for any work of the United States Government.' Title 17 U. S. C 101 defines a U. S. Government work as work prepared by a military service member of employee of the U. S. Government as part of that person's official duties. NR 23 TC 1 Z9 1 U1 0 U2 4 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0928-8244 J9 FEMS IMMUNOL MED MIC JI FEMS Immunol. Med. Microbiol. PD AUG PY 2012 VL 65 IS 3 BP 505 EP 509 DI 10.1111/j.1574-695X.2012.00974.x PG 5 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 975NA UT WOS:000306516800013 PM 22515653 ER PT J AU Ruiz, JF Hernanz, A Armitage, RA Rowe, MW Vinas, R Gavira-Vallejo, JM Rubio, A AF Ruiz, Juan F. Hernanz, Antonio Armitage, Ruth Ann Rowe, Marvin W. Vinas, Ramon Gavira-Vallejo, Jose M. Rubio, Albert TI Calcium oxalate AMS C-14 dating and chronology of post-Palaeolithic rock paintings in the Iberian Peninsula. Two dates from Abrigo de los Oculados (Henarejos, Cuenca, Spain) SO JOURNAL OF ARCHAEOLOGICAL SCIENCE LA English DT Article DE AMS C-14 dating; Calcium oxalate; Schematic art; Levantine art; Eye-idols; Abrigo de los Oculados ID CAVE PAINTINGS; LAS CUERDAS; AUSTRALIA; CARBON; SIERRA; ART AB Since 2005 we have been utilizing accelerator mass spectrometry (AMS) C-14 dating in research on calcium oxalate crusts associated with open air rock art of the Iberian Peninsula. In this paper we present two dates linked with three eye-idol pictographs at Abrigo de los Oculados (Henarejos, Cuenca, Spain). Radiocarbon ages for these motifs agree with the expected iconography-based archaeological chronology. Such oxalate dates could provide an independent basis for evaluating chronological theories for post-Palaeolithic sites, designated in the UNESCO World Heritage List as Rock Art of the Mediterranean Basin on the Iberian Peninsula. (C) 2012 Elsevier Ltd. All rights reserved. C1 [Ruiz, Juan F.] Univ Castilla La Mancha, Fac Ciencias Educ & Humanidades, Dpto Hist, Cuenca 16002, Spain. [Hernanz, Antonio; Gavira-Vallejo, Jose M.] Univ Nacl Educ Distancia, Fac Ciencias, Dpto Ciencias & Tecn Fis Quim, Madrid 28041, Spain. [Armitage, Ruth Ann] Eastern Michigan Univ, Dept Chem, Ypsilanti, MI 48197 USA. [Rowe, Marvin W.] USA, Museum New Mexico, Santa Fe, NM USA. [Rowe, Marvin W.] Texas A&M Univ Qatar, Dept Chem, Doha, Qatar. [Vinas, Ramon] Univ Rovira & Virgili, Inst Catala Paleoecol Humana & Evolucio Social IP, Tarragona, Spain. [Rubio, Albert] Univ Barcelona, Dept Prehist, Barcelona 08001, Spain. RP Ruiz, JF (reprint author), Univ Castilla La Mancha, Fac Ciencias Educ & Humanidades, Dpto Hist, Avda Alfares 42, Cuenca 16002, Spain. EM juanfrancisco.ruiz@uclm.es OI Ruiz, Juan F./0000-0002-7309-0102 FU Direccion General de Patrimonio y Museos, Consejeria de Cultura, Junta de Comunidades de Castilla - La Mancha (Spain); European Regional Development Fund (EDRF); Ministerio de Ciencia e Innovacion (MICINN), I + D + i project [CTQ2009-12489] FX This research was funded by a grant of Direccion General de Patrimonio y Museos, Consejeria de Cultura, Junta de Comunidades de Castilla - La Mancha (Spain). Additional financial support was granted by European Regional Development Fund (EDRF) and Ministerio de Ciencia e Innovacion (MICINN), I + D + i project CTQ2009-12489. The authors would like to acknowledge Dr. Egor Gavrilenko for assistance with microscopic polarized light images and thin section analyses, Dr. Tom Guilderson for AMS 14C dating, M.A. Mateo Saura for assistance with Murcia's sites (Spain), and Dr. J. Russ for their assistance with oxalate characterization. The Nikon SMZ belongs to the Dpt. Arqueologia y Prehistoria, UNED and we thank Dr. M. Mas for its use in this work and we thank Dr. B. Gavilan for the camera attached to the microscope. Finally, special mention needs to be made to Brian Akers for his accurate and thorough editing of our manuscript. NR 101 TC 13 Z9 13 U1 1 U2 15 PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD PI LONDON PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND SN 0305-4403 J9 J ARCHAEOL SCI JI J. Archaeol. Sci. PD AUG PY 2012 VL 39 IS 8 BP 2655 EP 2667 DI 10.1016/j.jas.2012.02.038 PG 13 WC Anthropology; Archaeology; Geosciences, Multidisciplinary SC Anthropology; Archaeology; Geology GA 970WT UT WOS:000306163700007 ER PT J AU Yoon, IK Rothman, AL Tannitisupawong, D Srikiatkhachorn, A Jarman, RG Aldstadt, J Nisalak, A Mammen, MP Thammapalo, S Green, S Libraty, DH Gibbons, RV Getis, A Endy, T Jones, JW Koenraadt, CJM Morrison, AC Fansiri, T Pimgate, C Scott, TW AF Yoon, In-Kyu Rothman, Alan L. Tannitisupawong, Darunee Srikiatkhachorn, Anon Jarman, Richard G. Aldstadt, Jared Nisalak, Ananda Mammen, Mammen P., Jr. Thammapalo, Suwich Green, Sharone Libraty, Daniel H. Gibbons, Robert V. Getis, Arthur Endy, Timothy Jones, James W. Koenraadt, Constantianus J. M. Morrison, Amy C. Fansiri, Thanyalak Pimgate, Chusak Scott, Thomas W. TI Underrecognized Mildly Symptomatic Viremic Dengue Virus Infections in Rural Thai Schools and Villages SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article ID KAMPHAENG PHET; AEDES-AEGYPTI; TRANSMISSION; CHILDREN; EPIDEMIOLOGY; BLOOD; SURVEILLANCE; INAPPARENT; INDONESIA; PATTERNS AB Background. The understanding of dengue virus (DENV) transmission dynamics and the clinical spectrum of infection are critical to informing surveillance and control measures. Geographic cluster studies can elucidate these features in greater detail than cohort studies alone. Methods. A 4-year longitudinal cohort and geographic cluster study was undertaken in rural Thailand. Cohort children underwent pre-/postseason serology and active school absence-based surveillance to detect inapparent and symptomatic dengue. Cluster investigations were triggered by cohort dengue and non-dengue febrile illnesses (positive and negative clusters, respectively). Results. The annual cohort incidence of symptomatic dengue ranged from 1.3% to 4.4%. DENV-4 predominated in the first 2 years, DENV-1 in the second 2 years. The inapparent-to-symptomatic infection ratio ranged from 1.1:1 to 2.9:1. Positive clusters had a 16.0% infection rate, negative clusters 1.1%. Of 119 infections in positive clusters, 59.7% were febrile, 20.2% were afebrile with other symptoms, and 20.2% were asymptomatic. Of 16 febrile children detected during cluster investigations who continued to attend school, 9 had detectable viremia. Conclusions. Dengue transmission risk was high near viremic children in both high- and low-incidence years. Inapparent infections in the cohort overestimated the rate of asymptomatic infections. Ambulatory children with mild febrile viremic infections could represent an important component of dengue transmission. C1 [Yoon, In-Kyu; Tannitisupawong, Darunee; Jarman, Richard G.; Nisalak, Ananda; Mammen, Mammen P., Jr.; Gibbons, Robert V.; Pimgate, Chusak] Armed Forces Res Inst Med Sci, Dept Virol, Bangkok 10400, Thailand. [Rothman, Alan L.] Univ Rhode Isl, Inst Immunol & Informat, Providence, RI 02908 USA. [Srikiatkhachorn, Anon; Green, Sharone; Libraty, Daniel H.] Univ Massachusetts, Sch Med, Dept Med, Div Infect Dis & Immunol, Worcester, MA 01605 USA. [Aldstadt, Jared] SUNY Buffalo, Dept Geog, Buffalo, NY 14260 USA. [Thammapalo, Suwich] Thailand Minist Publ Hlth, Dept Dis Control, Bur Vector Borne Dis, Nonthaburi, Thailand. [Getis, Arthur] San Diego State Univ, Dept Geog, San Diego, CA 92182 USA. [Endy, Timothy] SUNY Syracuse, Dept Infect Dis, Syracuse, NY USA. [Jones, James W.; Fansiri, Thanyalak] Armed Forces Res Inst Med Sci, Dept Entomol, Bangkok 10400, Thailand. [Koenraadt, Constantianus J. M.] Wageningen Univ, Entomol Lab, Wageningen, Netherlands. [Morrison, Amy C.; Scott, Thomas W.] Univ Calif Davis, Dept Entomol, Davis, CA 95616 USA. [Scott, Thomas W.] Fogarty Int Ctr, NIH, Bethesda, MD USA. RP Yoon, IK (reprint author), USAMC AFRIMS, APO, AP 96546 USA. EM yooni@afrims.org RI Aldstadt, Jared/A-8508-2009 OI Aldstadt, Jared/0000-0001-9162-7439 FU US National Institutes of Health [P01 AI34533, R01 GM083224]; US Military Infectious Diseases Research Program [S0016-04-AF]; Bill & Melinda Gates Foundation Global Health Program [OPP52250] FX This work was supported by the US National Institutes of Health (grant numbers P01 AI34533 and R01 GM083224); the US Military Infectious Diseases Research Program (grant number S0016-04-AF); and the Bill & Melinda Gates Foundation Global Health Program (grant number OPP52250). NR 30 TC 44 Z9 44 U1 1 U2 17 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD AUG 1 PY 2012 VL 206 IS 3 BP 389 EP 398 DI 10.1093/infdis/jis357 PG 10 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 973OI UT WOS:000306369100012 PM 22615312 ER PT J AU Montefiori, DC Karnasuta, C Huang, Y Ahmed, H Gilbert, P de Souza, MS McLinden, R Tovanabutra, S Laurence-Chenine, A Sanders-Buell, E Moody, MA Bonsignori, M Ochsenbauer, C Kappes, J Tang, HL Greene, K Gao, HM LaBranche, CC Andrews, C Polonis, VR Rerks-Ngarm, S Pitisuttithum, P Nitayaphan, S Kaewkungwal, J Self, SG Berman, PW Francis, D Sinangil, F Lee, C Tartaglia, J Robb, ML Haynes, BF Michael, NL Kim, JH AF Montefiori, David C. Karnasuta, Chitraporn Huang, Ying Ahmed, Hasan Gilbert, Peter de Souza, Mark S. McLinden, Robert Tovanabutra, Sodsai Laurence-Chenine, Agnes Sanders-Buell, Eric Moody, M. Anthony Bonsignori, Mattia Ochsenbauer, Christina Kappes, John Tang, Haili Greene, Kelli Gao, Hongmei LaBranche, Celia C. Andrews, Charla Polonis, Victoria R. Rerks-Ngarm, Supachai Pitisuttithum, Punnee Nitayaphan, Sorachai Kaewkungwal, Jaranit Self, Steve G. Berman, Phillip W. Francis, Donald Sinangil, Faruk Lee, Carter Tartaglia, Jim Robb, Merlin L. Haynes, Barton F. Michael, Nelson L. Kim, Jerome H. TI Magnitude and Breadth of the Neutralizing Antibody Response in the RV144 and Vax003 HIV-1 Vaccine Efficacy Trials SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article ID IMMUNODEFICIENCY-VIRUS TYPE-1; MONOCLONAL-ANTIBODIES; CHIMERIC VIRUS; DOUBLE-BLIND; SUBTYPE-B; INFECTION; PROTECTION; THAILAND; PHASE-3; BINDING AB Background. A recombinant canarypox vector expressing human immunodeficiency virus type 1 (HIV-1) Gag, Pro, and membrane-linked gp120 (vCP1521), combined with a bivalent gp120 protein boost (AIDSVAX B/E), provided modest protection against HIV-1 infection in a community-based population in Thailand (RV144 trial). No protection was observed in Thai injection drug users who received AIDSVAX B/E alone (Vax003 trial). We compared the neutralizing antibody response in these 2 trials. Methods. Neutralization was assessed with tier 1 and tier 2 strains of virus in TZM-bl and A3R5 cells. Results. Neutralization of several tier 1 viruses was detected in both RV144 and Vax003. Peak titers were higher in Vax003 and waned rapidly in both trials. The response in RV144 was targeted in part to V3 of gp120. vCP1521 priming plus 2 boosts with gp120 protein was superior to 2 gp120 protein inoculations alone, confirming a priming effect for vCP1521. Sporadic weak neutralization of tier 2 viruses was detected only in Vax003 and A3R5 cells. Conclusion. The results suggest either that weak neutralizing antibody responses can be partially protective against HIV-1 in low-risk heterosexual populations or that the modest efficacy seen in RV144 was mediated by other immune responses, either alone or in combination with neutralizing antibodies. C1 [Montefiori, David C.] Duke Univ, Med Ctr, Dept Surg, Durham, NC 27710 USA. [Karnasuta, Chitraporn; de Souza, Mark S.; Nitayaphan, Sorachai] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Huang, Ying; Ahmed, Hasan; Gilbert, Peter; Self, Steve G.] Fred Hutchinson Canc Res Ctr, Seattle, WA 98104 USA. [McLinden, Robert; Tovanabutra, Sodsai; Laurence-Chenine, Agnes; Sanders-Buell, Eric; Andrews, Charla; Polonis, Victoria R.; Robb, Merlin L.; Michael, Nelson L.; Kim, Jerome H.] Walter Reed Army Inst Res, US Mil HIV Res Program, Rockville, MD USA. [Ochsenbauer, Christina; Kappes, John] Univ Alabama Birmingham, Birmingham, AL USA. [Rerks-Ngarm, Supachai] Minist Publ Hlth, Dept Dis Control, Bangkok, Thailand. [Pitisuttithum, Punnee; Kaewkungwal, Jaranit] Mahidol Univ, Fac Trop Med, Bangkok 10700, Thailand. [Berman, Phillip W.] Univ Calif Santa Cruz, Baskin Sch Engn, Santa Cruz, CA 95064 USA. [Francis, Donald; Sinangil, Faruk; Lee, Carter] Global Solut Infect Dis, San Francisco, CA USA. [Tartaglia, Jim] Sanofi Pasteur, Toronto, ON, Canada. RP Montefiori, DC (reprint author), Duke Univ, Med Ctr, Dept Surg, Box 2926, Durham, NC 27710 USA. EM monte@duke.edu OI Moody, Tony/0000-0002-3890-5855 FU Bill & Melinda Gates Foundation; Center for HIV/AIDS Vaccine Immunology (Division of Acquired Immunodeficiency Syndrome, NIAID, NIH) [AI678501]; US Army Medical Research [Y1-AI-2642-12]; NIAID; Materiel Command [Y1-AI-2642-12]; Henry M. Jackson Foundation for the Advancement of Military Medicine [W81XWH-07-2-0067]; US Department of Defense [W81XWH-07-2-0067] FX This study was supported by the Bill & Melinda Gates Foundation Collaboration for AIDS Vaccine Discovery, by the Center for HIV/AIDS Vaccine Immunology (grant AI678501 from the Division of Acquired Immunodeficiency Syndrome, NIAID, NIH), and by an interagency agreement (Y1-AI-2642-12) between the US Army Medical Research and Materiel Command and the NIAID. This work was also supported by a cooperative agreement (W81XWH-07-2-0067) between the Henry M. Jackson Foundation for the Advancement of Military Medicine and the US Department of Defense. NR 50 TC 142 Z9 144 U1 1 U2 15 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD AUG 1 PY 2012 VL 206 IS 3 BP 431 EP 441 DI 10.1093/infdis/jis367 PG 11 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 973OI UT WOS:000306369100017 PM 22634875 ER PT J AU Grujicic, M Bell, WC Pandurangan, B Cheeseman, BA Fountzoulas, C Patel, P AF Grujicic, M. Bell, W. C. Pandurangan, B. Cheeseman, B. A. Fountzoulas, C. Patel, P. TI Molecular-Level Simulations of Shock Generation and Propagation in Soda-Lime Glass SO JOURNAL OF MATERIALS ENGINEERING AND PERFORMANCE LA English DT Article DE ballistic-impact; non-equilibrium molecular dynamics simulations; shock-wave formation/propagation; soda-lime glass ID BALLISTIC MATERIAL MODEL; BRITTLE MATERIALS; MECHANICAL-PROPERTIES; FORCE-FIELD; PRESSURE; DYNAMICS; FRAGMENTATION; TRANSITION; POLYUREA; COMPASS AB A non-equilibrium molecular dynamics method is employed to study the mechanical response of soda-lime glass (a material commonly used in transparent armor applications) when subjected to the loading conditions associated with the generation and propagation of planar shock waves. Specific attention is given to the identification and characterization of various (inelastic-deformation and energy-dissipation) molecular-level phenomena and processes taking place at, or in the vicinity of, the shock front. The results obtained revealed that the shock loading causes a 2-4% (shock strength-dependent) density increase. In addition, an increase in the average coordination number of the silicon atoms is observed along with the creation of smaller Si-O rings. These processes are associated with substantial energy absorption and dissipation and are believed to greatly influence the blast/ballistic impact mitigation potential of soda-lime glass. The present work was also aimed at the determination of the shock Hugoniot (i.e., a set of axial stress vs. density/specific-volume vs. internal energy vs. particle velocity vs. temperature) material states obtained in soda-lime glass after the passage of a shock wave of a given strength (as quantified by the shock speed). The availability of a shock Hugoniot is critical for construction of a high deformation-rate, large-strain, high pressure material model which can be used within a continuum-level computational analysis to capture the response of a soda-lime glass based laminated transparent armor structure (e.g., a military vehicle windshield, door window, etc.) to blast/ballistic impact loading. C1 [Grujicic, M.; Bell, W. C.; Pandurangan, B.] Clemson Univ, Dept Mech Engn, Clemson, SC 29634 USA. [Cheeseman, B. A.; Fountzoulas, C.; Patel, P.] USA, Res Lab, Survivabil Mat Branch, Proving Ground, MD 21005 USA. RP Grujicic, M (reprint author), Clemson Univ, Dept Mech Engn, 241 Engn Innovat Bldg, Clemson, SC 29634 USA. EM gmica@exchange.clemson.edu FU U.S. Army/Clemson University [W911NF-04-2-0024, W911NF-06-2-0042]; ARC-TARDEC FX The material presented in this paper is based on work supported by the U.S. Army/Clemson University Cooperative Agreements W911NF-04-2-0024 and W911NF-06-2-0042 and by an ARC-TARDEC research contract. NR 29 TC 9 Z9 9 U1 0 U2 13 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1059-9495 EI 1544-1024 J9 J MATER ENG PERFORM JI J. Mater. Eng. Perform. PD AUG PY 2012 VL 21 IS 8 BP 1580 EP 1590 DI 10.1007/s11665-011-0064-4 PG 11 WC Materials Science, Multidisciplinary SC Materials Science GA 975ZD UT WOS:000306549400003 ER PT J AU Dietrich, JC Tanaka, S Westerink, JJ Dawson, CN Luettich, RA Zijlema, M Holthuijsen, LH Smith, JM Westerink, LG Westerink, HJ AF Dietrich, J. C. Tanaka, S. Westerink, J. J. Dawson, C. N. Luettich, R. A., Jr. Zijlema, M. Holthuijsen, L. H. Smith, J. M. Westerink, L. G. Westerink, H. J. TI Performance of the Unstructured-Mesh, SWAN plus ADCIRC Model in Computing Hurricane Waves and Surge SO JOURNAL OF SCIENTIFIC COMPUTING LA English DT Article DE Hurricane waves; Storm surge; Unstructured meshes ID SHALLOW-WATER EQUATIONS; SOUTHERN LOUISIANA; WIND; COMPUTATIONS; VALIDATION; GUSTAV; SCALE AB Coupling wave and circulation models is vital in order to define shelf, nearshore and inland hydrodynamics during a hurricane. The intricacies of the inland floodplain domain, level of required mesh resolution and physics make these complex computations very cycle-intensive. Nonetheless, fast wall-clock times are important, especially when forecasting an incoming hurricane. We examine the performance of the unstructured-mesh, SWAN+ADCIRC wave and circulation model applied to a high-resolution, 5M-vertex, finite-element SL16 mesh of the Gulf of Mexico and Louisiana. This multi-process, multi-scale modeling system has been integrated by utilizing inter-model communication that is intra-core. The modeling system is validated through hindcasts of Hurricanes Katrina and Rita (2005), Gustav and Ike (2008) and comprehensive comparisons to wave and water level measurements throughout the region. The performance is tested on a variety of platforms, via the examination of output file requirements and management, and the establishment of wall-clock times and scalability using up to 9,216 cores. Hindcasts of waves and storm surge can be computed efficiently, by solving for as many as 2.3a <...10(12) unknowns per day of simulation, in as little as 10 minutes of wall-clock time. C1 [Dietrich, J. C.; Tanaka, S.; Westerink, J. J.; Westerink, L. G.; Westerink, H. J.] Univ Notre Dame, Dept Civil Engn & Geol Sci, Notre Dame, IN 46556 USA. [Dietrich, J. C.; Dawson, C. N.] Univ Texas Austin, Inst Computat Engn & Sci, Austin, TX 78712 USA. [Luettich, R. A., Jr.] Univ N Carolina, Inst Marine Sci, Chapel Hill, NC USA. [Zijlema, M.; Holthuijsen, L. H.] Delft Univ Technol, Fac Civil Engn & Geosci, Delft, Netherlands. [Smith, J. M.] USA, Corps Engineers, Coastal Hydraul Lab, Vicksburg, MS 39180 USA. RP Dietrich, JC (reprint author), Univ Texas Austin, Inst Computat Engn & Sci, 1 Univ Stn C0200, Austin, TX 78712 USA. EM dietrich@ices.utexas.edu RI Dietrich, Joel/E-5161-2011; Zijlema, Marcel/J-3099-2013 OI Dietrich, Joel/0000-0001-5294-2874; FU National Science Foundation [DMS-0915223, OCI-0749015, OCI-0746232] FX This work was supported by awards from the National Science Foundation (DMS-0915223, OCI-0749015 and OCI-0746232). NR 38 TC 42 Z9 48 U1 2 U2 34 PU SPRINGER/PLENUM PUBLISHERS PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0885-7474 J9 J SCI COMPUT JI J. Sci. Comput. PD AUG PY 2012 VL 52 IS 2 BP 468 EP 497 DI 10.1007/s10915-011-9555-6 PG 30 WC Mathematics, Applied SC Mathematics GA 976LW UT WOS:000306587200010 ER PT J AU Singer, S Wang, GX Howard, H Anderson, A AF Singer, Steve Wang, Guangxing Howard, Heidi Anderson, Alan TI Environmental Condition Assessment of US Military Installations Using GIS Based Spatial Multi-Criteria Decision Analysis SO ENVIRONMENTAL MANAGEMENT LA English DT Article DE Assessment; Environmental condition; GIS; Military installation; Spatial integration; Decision analysis ID USE SUITABILITY ANALYSIS; LONG-TERM DISTURBANCE; LAND-USE ACTIVITIES; SOIL-EROSION; TM IMAGES; GEOSTATISTICAL METHODS; TRACKED VEHICLES; PLANT COMMUNITY; TRAINING LANDS; CO-SIMULATION AB Environment functions in various aspects including soil and water conservation, biodiversity and habitats, and landscape aesthetics. Comprehensive assessment of environmental condition is thus a great challenge. The issues include how to assess individual environmental components such as landscape aesthetics and integrate them into an indicator that can comprehensively quantify environmental condition. In this study, a geographic information systems based spatial multi-criteria decision analysis was used to integrate environmental variables and create the indicator. This approach was applied to Fort Riley Military installation in which land condition and its dynamics due to military training activities were assessed. The indicator was derived by integrating soil erosion, water quality, landscape fragmentation, landscape aesthetics, and noise based on the weights from the experts by assessing and ranking the environmental variables in terms of their importance. The results showed that landscape level indicator well quantified the overall environmental condition and its dynamics, while the indicator at level of patch that is defined as a homogeneous area that is different from its surroundings detailed the spatiotemporal variability of environmental condition. The environmental condition was mostly determined by soil erosion, then landscape fragmentation, water quality, landscape aesthetics, and noise. Overall, environmental condition at both landscape and patch levels greatly varied depending on the degree of ground and canopy disturbance and their spatial patterns due to military training activities and being related to slope. It was also determined the environment itself could be recovered quickly once military training was halt or reduced. Thus, this study provided an effective tool for the army land managers to monitor environmental dynamics and plan military training activities. Its limitation lies at that the obtained values of the indicator vary and are subjective to the experts' knowledge and experience. Thus, further advancing this approach is needed by developing a scientific method to derive the weights of environmental variables. C1 [Singer, Steve; Wang, Guangxing] So Illinois Univ, Dept Geog & Environm Resources, Carbondale, IL 62901 USA. [Howard, Heidi; Anderson, Alan] ERDC CERL, Champaign, IL USA. RP Wang, GX (reprint author), So Illinois Univ, Dept Geog & Environm Resources, Faner Hall 4520,1000 Faner Dr, Carbondale, IL 62901 USA. EM gxwang@siu.edu; Heidi.R.Howard@usace.army.mil FU US Army Corps of Engineers, Construction Engineering Research Laboratory (USA-CERL) [CERL W9132T-08-2-0019] FX We are grateful to US Army Corps of Engineers, Construction Engineering Research Laboratory (USA-CERL) for providing support (CERL W9132T-08-2-0019) and data sets for this study and also to the editors and reviewers. NR 50 TC 4 Z9 5 U1 1 U2 35 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0364-152X J9 ENVIRON MANAGE JI Environ. Manage. PD AUG PY 2012 VL 50 IS 2 BP 329 EP 340 DI 10.1007/s00267-012-9873-y PG 12 WC Environmental Sciences SC Environmental Sciences & Ecology GA 971AO UT WOS:000306174200013 PM 22684636 ER PT J AU Mitchell-Blackwood, J Gurian, PL Lee, R Thran, B AF Mitchell-Blackwood, J. Gurian, P. L. Lee, R. Thran, B. TI Variance in Bacillus anthracis virulence assessed through Bayesian hierarchical dose-response modelling SO JOURNAL OF APPLIED MICROBIOLOGY LA English DT Article DE Bacillus anthracis; dose-response modelling; environmental; spores; virulence ID ENVIRONMENTAL EXPOSURE; RISK; INHALATION; SPORES AB Aims: To develop a predictive doseresponse model for describing the survival of animals exposed to Bacillus anthracis to support risk management options. Methods and Results: Doseresponse curves were generated from a large dosemortality data set (>11 000 data points) consisting of guinea pigs exposed via the inhalation route to 76 different product preparations of B.similar to anthracis. Because of the predictive nature of the Bayesian hierarchical approach (BHA), this method was used. The utility of this method in planning for a variety of scenarios from best case to worst case was demonstrated. Conclusions: A wide range of expected virulence was observed across products. Median estimates of virulence match well with previously published statistical estimates, but upper bound values of virulence are much greater than previous statistical estimates. Significance and Impact of the Study: This study is the first meta-analysis in open literature to estimate the doseresponse relationship for B.similar to anthracis from a very large data set, generally a rare occurrence for highly infectious pathogens. The results are also the first to suggest the extent of variability, which is contributed by product preparation and/or dissemination methods, information needed for health-based risk management decisions in response to a deliberate release. A set of possible benchmark values produced through this analysis can be tied to the risk tolerance of the decision-maker or available intelligence. Further, the substantial size of the data set led to the ability to assess the appropriateness of the assumed distributional form of the prior, a common limitation in Bayesian analysis. C1 [Mitchell-Blackwood, J.; Gurian, P. L.] Drexel Univ, Dept Civil Architectural & Environm Engn, Philadelphia, PA 19104 USA. [Mitchell-Blackwood, J.] US EPA, Natl Exposure Res Lab, Res Triangle Pk, NC 27711 USA. [Lee, R.] USA, Med Res Inst Chem Def, Aberdeen Proving Ground, MD 21010 USA. [Lee, R.; Thran, B.] USA, Environm Hlth Risk Assessment Program, Hlth Risk Management Portfolio, Publ Hlth Command Army Inst Publ Hlth, Aberdeen Proving Ground, MD USA. RP Mitchell-Blackwood, J (reprint author), Food Safety & Inspect Serv, USDA, 1400 Independence Ave,Stop 3766, Washington, DC 20250 USA. EM mitchell-blackwood.jade@epa.gov RI Gurian, Patrick/A-8365-2013 OI Gurian, Patrick/0000-0001-7456-9740 FU US Army, of the Pathogen Information Catalog (PICAT); US Army Center for Health Promotion and Preventive Medicine (USACHPPM); Center for Advancing Microbial Risk Assessment; US Department of Homeland Security; US Environmental Protection Agency under the Science to Achieve Results (STAR) grant program [R83236201] FX The authors would like to thank Drs Tonya Nichols and Sarah Taft (US Environmental Protection Agency, National Homeland Security Research Center) for joint financial support, with the US Army, of the Pathogen Information Catalog (PICAT), which houses the data set, and their technical contributions to the project. Stephanie Hines (Battelle) also contributed during technical discussions. Ms. Erin Curran (US Army Public Health Command was instrumental in the gathering of the original research reports, and Peg Coleman, Stacey Massulik, Michele Stephenson, and Lisa Lowe (Syracuse Research Corporation) were instrumental in the population of the PICAT. Portions of this research were supported in part by an appointment to the Student Research Participation Program at the US Army Center for Health Promotion and Preventive Medicine (USACHPPM) administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the US Department of Energy and USACHPPM. Additional support was provided by the Center for Advancing Microbial Risk Assessment, which is supported by the US Department of Homeland Security and the US Environmental Protection Agency under the Science to Achieve Results (STAR) grant program (grant no. R83236201). NR 18 TC 4 Z9 4 U1 0 U2 7 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1364-5072 J9 J APPL MICROBIOL JI J. Appl. Microbiol. PD AUG PY 2012 VL 113 IS 2 BP 265 EP 275 DI 10.1111/j.1365-2672.2012.05311.x PG 11 WC Biotechnology & Applied Microbiology; Microbiology SC Biotechnology & Applied Microbiology; Microbiology GA 974AF UT WOS:000306401300005 PM 22515543 ER PT J AU Ma, Q Prater, JT Sudakar, C Rosenberg, RA Narayan, J AF Ma, Q. Prater, J. T. Sudakar, C. Rosenberg, R. A. Narayan, J. TI Defects in room-temperature ferromagnetic Cu-doped ZnO films probed by x-ray absorption spectroscopy SO JOURNAL OF PHYSICS-CONDENSED MATTER LA English DT Article ID DILUTE MAGNETIC SEMICONDUCTORS; FINE-STRUCTURE; ORIGIN; COPPER; OXIDE AB We report a comprehensive study of the defects in room-temperature ferromagnetic (RTFM) Cu-doped ZnO thin films using x-ray absorption spectroscopy. The films are doped with 2 at.% Cu, and are prepared by reactive magnetron sputtering (RMS) and pulsed laser deposition (PLD), respectively. The results reveal unambiguously that atomic point defects exist in these RTFM thin films. The valence states of the Cu ions in both films are 2(+). In the film prepared by PLD, the oxygen vacancies (V-O) form around both Zn ions and Cu ions in the hexagonal wurtzite structure. Upon annealing of the film in O-2, the V-O population reduces and so does the RTFM. In the film prepared by RMS, the V(O)s around Cu ions are not detected, and the V-O population around Zn ions is also smaller than in the PLD-prepared film. However, zinc vacancies (V-Zn) are evidenced. Given the low doping level of spin-carrying Cu ions, these results provide strong support for defect-mediated ferromagnetism in Cu-doped ZnO thin C1 [Ma, Q.] Argonne Natl Lab, Adv Photon Source, NW Synchrotron Res Ctr, DND CAT, Argonne, IL 60439 USA. [Prater, J. T.] USA, Res Off, Div Mat Sci, Res Triangle Pk, NC 27709 USA. [Prater, J. T.; Narayan, J.] N Carolina State Univ, Dept Mat Sci & Engn, Raleigh, NC 27695 USA. [Sudakar, C.] Wayne State Univ, Dept Phys & Astron, Detroit, MI 48201 USA. RP Ma, Q (reprint author), Argonne Natl Lab, Adv Photon Source, NW Synchrotron Res Ctr, DND CAT, Argonne, IL 60439 USA. EM q-ma@northwestern.edu RI Rosenberg, Richard/K-3442-2012; Sudakar, Chandran/A-6067-2008; Sudakar, C./A-3393-2013 OI Sudakar, C./0000-0003-2863-338X FU E I DuPont de Nemours Co.; Dow Chemical Company; State of Illinois; US Department of Energy, Office of Science, Office of Basic Energy Sciences [DE-AC02-06CH11357] FX x-ray absorption spectroscopy experiments are carried out at the DND-CAT located at Sector 5 of the Advanced Photon Source (APS). DND-CAT is supported by E I DuPont de Nemours & Co., The Dow Chemical Company and the State of Illinois. Use of the APS was supported by the US Department of Energy, Office of Science, Office of Basic Energy Sciences, under Contract No. DE-AC02-06CH11357. CS acknowledges G Lawes at Department of Physics and Astronomy, Wayne State University for magnetic measurements. NR 52 TC 11 Z9 11 U1 1 U2 38 PU IOP PUBLISHING LTD PI BRISTOL PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND SN 0953-8984 J9 J PHYS-CONDENS MAT JI J. Phys.-Condes. Matter PD AUG 1 PY 2012 VL 24 IS 30 AR 306002 DI 10.1088/0953-8984/24/30/306002 PG 9 WC Physics, Condensed Matter SC Physics GA 974BU UT WOS:000306405600017 PM 22763657 ER PT J AU Sia, RK Ryan, DS Stutzman, RD Psolka, M Mines, MJ Wagner, ME Weber, ED Wroblewski, KJ Bower, KS AF Sia, Rose K. Ryan, Denise S. Stutzman, Richard D. Psolka, Maximilian Mines, Michael J. Wagner, Melvin E. Weber, Eric D. Wroblewski, Keith J. Bower, Kraig S. TI Alcohol versus brush PRK: Visual outcomes and adverse effects SO LASERS IN SURGERY AND MEDICINE LA English DT Article DE complications; cornea; debridement; epithelium ID EPITHELIAL REMOVAL TECHNIQUES; PHOTOREFRACTIVE KERATECTOMY; REFRACTIVE SURGERY; MECHANICAL DEBRIDEMENT; STANDARDIZED GRAPHS; EXCIMER-LASER; CORNEAL HAZE; TERMS AB Background and Objective A smooth corneal surface prior to laser ablation is important in order to achieve a favorable refractive outcome. In this study, we compare PRK outcomes following two commonly used methods of epithelial debridement: Amoils epithelial scrubber (brush) versus 20% ethanol (alcohol). Study Design/Patients and Methods We reviewed records of patients who underwent wavefront-optimized PRK for myopia or myopic astigmatism between January 2008 and June 2010. Two treatment groups (brush vs. alcohol) were compared in terms of uncorrected distance visual acuity (UDVA), manifest refraction spherical equivalent (MRSE), corrected distance visual acuity (CDVA), and complications at postoperative months 1, 3, 6, and 12. Results One thousand five hundred ninety-three eyes of 804 patients underwent PRK during the study period: 828 brush-treated eyes and 765 alcohol-treated eyes. At 6 months postoperatively UDVA was =20/20 in 94.7% of brush-treated eyes versus 94.4% of alcohol-treated eyes (P?=?0.907). At 1 month a higher percentage of brush-treated eyes maintained or gained one or more lines CDVA compared to alcohol-treated eyes (P?=?0.007), but there were no other differences in UDVA, MRSE, or CDVA at any point postoperatively. At 1 month 75.4% of brush-treated eyes versus 70.4% of alcohol-treated eyes were free of complications (P?=?0.032), and there were fewer brush-treated eyes with corneal haze (4.0% vs. 6.9%, P?=?0.012) and dry eye (8.9% vs. 14.4%, P?=?0.001). Although corneal haze was slightly more frequent in the alcohol group, most was trace and not significant. Conclusions Although alcohol-assisted PRK had more minor complications in the early postoperative period, including corneal haze and dry eye, results for both groups beyond 1 month were comparable. Lasers Surg. Med. 44: 475481, 2012. (C) Wiley Periodicals, Inc. C1 [Sia, Rose K.; Ryan, Denise S.] Ft Belvoir Community Hosp, USA, Warfighter Refract Surg Res Ctr Ft Belvoir, Ft Belvoir, VA 22060 USA. [Stutzman, Richard D.; Mines, Michael J.; Wagner, Melvin E.; Weber, Eric D.; Wroblewski, Keith J.] Walter Reed Natl Mil Med Ctr, Bethesda, MD 20889 USA. [Psolka, Maximilian] Keller Army Hosp, West Point, NY 10996 USA. [Bower, Kraig S.] Johns Hopkins Univ, Wilmer Eye Inst, Baltimore, MD 21287 USA. RP Sia, RK (reprint author), Community Hosp, USA, Warfighter Refract Surg Res Ctr Ft Belvoir Ft Bel, 9300 DeWitt Loop,Meadows M2-R3, Ft Belvoir, VA 22060 USA. EM rose.sia@us.army.mil NR 18 TC 2 Z9 2 U1 1 U2 3 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0196-8092 J9 LASER SURG MED JI Lasers Surg. Med. PD AUG PY 2012 VL 44 IS 6 BP 475 EP 481 DI 10.1002/lsm.22036 PG 7 WC Dermatology; Surgery SC Dermatology; Surgery GA 972YL UT WOS:000306317500006 PM 22674627 ER PT J AU Qiu, HW Stepanov, V Chou, TM Surapaneni, A Di Stasio, AR Lee, WY AF Qiu, Hongwei Stepanov, Victor Chou, Tsengming Surapaneni, Ashok Di Stasio, Anthony R. Lee, Woo Y. TI Single-step production and formulation of HMX nanocrystals SO POWDER TECHNOLOGY LA English DT Article DE HMX; Nanocrystals; Nanocomposite; Granules; Spray drying ID SENSITIVITY; MORPHOLOGY; SIZE; RDX AB We assessed the feasibility of single-step production of nanocrystalline cyclotetramethylene tetranitramine (HMX)-based composite granules by spray drying. Acetone solution of HMX and a polymeric binder was spray-dried using a commercially available spray dryer equipped with a compressed gas nozzle. During spray drying both ingredients precipitated simultaneously under high degrees of supersaturation, conditions necessary for small crystal size. The product was characterized using focused ion beam coupled scanning electron microscopy (FIB-SEM), transmission electron microscopy (TEM), X-ray diffraction (XRD), and high-performance liquid chromatography (HPLC). We found that similar to 1 mu m composite granules were formed comprised of sub-100 nm HMX crystals dispersed in the binder matrix. gamma and delta polymorphs of HMX were found in the product. Due to its simplicity, the spray drying method lends itself to facile production of bulk quantities of a variety of nanocomposite energetics. (C) 2012 Elsevier B.V. All rights reserved. C1 [Qiu, Hongwei; Chou, Tsengming; Lee, Woo Y.] Stevens Inst Technol, Dept Chem Engn & Mat Sci, Hoboken, NJ 07030 USA. [Stepanov, Victor; Surapaneni, Ashok; Di Stasio, Anthony R.] USA, Armament Res Dev & Engn Ctr, Picatinny Arsenal, NJ 07806 USA. RP Qiu, HW (reprint author), Stevens Inst Technol, Dept Chem Engn & Mat Sci, Hoboken, NJ 07030 USA. EM hqiu@stevens.edu FU U.S. Army, ARDEC [W15QKN-05-D-0011]; National Science Foundation [DMR-0922522] FX This work was funded by the U.S. Army, ARDEC under the contract of W15QKN-05-D-0011. We also thank Aleksander Gandzelko for assistance with HPLC analysis. This research effort used microscope resources partially funded by the National Science Foundation through NSF Grant DMR-0922522. NR 18 TC 21 Z9 26 U1 4 U2 25 PU ELSEVIER SCIENCE SA PI LAUSANNE PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND SN 0032-5910 J9 POWDER TECHNOL JI Powder Technol. PD AUG PY 2012 VL 226 BP 235 EP 238 DI 10.1016/j.powtec.2012.04.053 PG 4 WC Engineering, Chemical SC Engineering GA 972DE UT WOS:000306255900030 ER PT J AU Morehead-Gee, AJ Pfalzer, L Levy, E McGarvey, C Springer, B Soballe, P Gerber, L Stout, NL AF Morehead-Gee, Alicia J. Pfalzer, Lucinda Levy, Ellen McGarvey, Charles Springer, Barbara Soballe, Peter Gerber, Lynn Stout, Nicole L. TI Racial disparities in physical and functional domains in women with breast cancer SO SUPPORTIVE CARE IN CANCER LA English DT Article DE Breast cancer; Health status; Health-related quality of life; Race; Physical impairment; Health disparities ID QUALITY-OF-LIFE; AXILLARY WEB SYNDROME; PREOPERATIVE ASSESSMENT ENABLES; SF-36 HEALTH SURVEY; SOCIOECONOMIC-STATUS; AFRICAN-AMERICAN; ARM LYMPHEDEMA; WHITE WOMEN; ETHNIC DISPARITIES; EARLY-DIAGNOSIS AB African-American women are more likely than white women to have functional impairments after breast cancer (BC) surgery; however, no differences were found in self-reported health status surveys at 12+ months postsurgery. This analysis compared white and African-American BC survivors' (BCS) health status, health-related quality of life, and the occurrence of physical impairments after BC treatment. One hundred sixty-six women (130 white, 28 African-American, 8 other) were assessed for impairments preoperatively and at 1, 3, 6, 9, and 12+ months postsurgery. Health status was assessed at 12+ months using the Short Form Health Survey (SF36v2 (TM)). Analysis of variance estimated differences between groups for health status and impairment occurrence. No differences were found between groups for BC type, stage, grade, or tumor size; surgery type; or number of lymph nodes sampled. African-American BCS had more estrogen/progesterone receptor-negative tumors (p < 0.001; p = 0.036) and received radiation more frequently (p = 0.03). More African-American BCS were employed (p = 0.022) and reported higher rates of social activities (p = 0.011) but less recreational activities (p = 0.020) than white BCS. African-American BCS had higher rates of cording (p = 0.013) and lymphedema (p = 0.011) postoperatively. No differences were found in self-reported health status. In a military healthcare system, where access to care is ubiquitous, there were no significant differences in many BC characteristics commonly attributed to race. African-American women had more ER/PR-negative tumors; however, no other BC characteristics differed between racial groups. African-American women exhibited more physical impairments, although their BC treatment only differed regarding radiation therapy. This suggests that African-American BCS may be at higher risk for physical impairments and should be monitored prospectively for early identification and treatment. C1 [Stout, Nicole L.] Natl Naval Med Ctr, Breast Care Ctr, Bethesda, MD 20889 USA. [Morehead-Gee, Alicia J.; Levy, Ellen] NIH, Dept Rehabil Med, Ctr Clin, Bethesda, MD 20892 USA. [Pfalzer, Lucinda] Univ Michigan, Phys Therapy Dept, Flint, MI 48503 USA. [McGarvey, Charles] CLM Consulting, Rockville, MD USA. [Springer, Barbara] USA, Off Surg Gen, Rehabil & Reintegrat Div, Falls Church, VA USA. [Soballe, Peter] USN Hosp, San Diego, CA 92134 USA. [Gerber, Lynn] George Mason Univ, Coll Hlth & Human Serv, Fairfax, VA 22030 USA. RP Stout, NL (reprint author), Natl Naval Med Ctr, Breast Care Ctr, 8901 Wisconsin Ave,Bldg 19,3rd Floor, Bethesda, MD 20889 USA. EM Nicole.stout@med.navy.mil FU National Naval Medical Center (National Naval Medical Center [NNMC]) [NNMC 2001-052]; National Institutes of Health (NIH), Clinical Center, Rehabilitation Medicine Department, Physical Therapy Section [NIH 02-CC-0044] FX This study was supported by the National Naval Medical Center (National Naval Medical Center [NNMC] Protocol NNMC 2001-052) and by the National Institutes of Health (NIH), Clinical Center, Rehabilitation Medicine Department, Physical Therapy Section (Protocol NIH 02-CC-0044). NR 48 TC 7 Z9 7 U1 2 U2 6 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0941-4355 EI 1433-7339 J9 SUPPORT CARE CANCER JI Support. Care Cancer PD AUG PY 2012 VL 20 IS 8 BP 1839 EP 1847 DI 10.1007/s00520-011-1285-7 PG 9 WC Oncology; Health Care Sciences & Services; Rehabilitation SC Oncology; Health Care Sciences & Services; Rehabilitation GA 970LG UT WOS:000306129600030 PM 21979903 ER PT J AU Bryant, DB Whilden, KA Socolofsky, SA Chang, KA AF Bryant, Duncan B. Whilden, Kerri A. Socolofsky, Scott A. Chang, Kuang-An TI Formation of tidal starting-jet vortices through idealized barotropic inlets with finite length SO ENVIRONMENTAL FLUID MECHANICS LA English DT Article DE Vortex dynamics; Tidal exchange; Vortex interaction; Shallow waterflow ID SCALE FLOW STRUCTURES; SHALLOW FLOWS; TURBULENT; FIELD; MODEL AB This paper presents a surface particle image velocimetry study to investigate the dynamics of shallow starting-jet dipoles formed by tidal flow through inlets and their interaction with vorticity formed at the inlet channel lateral boundaries. Vortical structure in the flow field is identified using a local swirl strength criterion evaluated from the two-dimensional flow field. The starting jet dipole vortices and vortices formed as the lateral boundary layers are expelled during flow reversal are characterized by their trajectory, size, and circulation. Using these quantities, a model is developed to predict the size and strength of the expelled lateral boundary layer vortices based on the inlet velocity, channel length, and width of the lateral boundary layer. The expelled boundary layer vortices are found to disrupt the formation of the primary tidal jet dipole through two mechanisms. First, because the boundary layer vortices themselves form a dipole with each half of the starting-jet dipole, the starting-jet vortices are pulled apart and advected away from the inlet mouth early in the tidal cycle, resulting in a reduction in the spin-up time and the amount of vorticity input during starting-jet vortex formation. Second, the advection of each dipole away from the inlet disconnects each starting-jet vortex from the starting jet; hence, the vortices are not fed by fluid in the jet or energized by shear in the jet boundary layers. These influences of the lateral boundary layer on the starting-jet vortices' formation and propagation are found to be a function of the channel length L, maximum velocity U, and tidal period T, resulting in a predictive value to characterize their trajectory, strength, and evolution. C1 [Bryant, Duncan B.] USA, Engineers Res & Dev Ctr, Coastal & Hydraul Lab, Vicksburg, MS 39180 USA. [Whilden, Kerri A.; Socolofsky, Scott A.; Chang, Kuang-An] Texas A&M Univ, Coastal & Ocean Engn Div, Zachry Dept Civil Engn, Colleamge Stn, TX USA. RP Bryant, DB (reprint author), USA, Engineers Res & Dev Ctr, Coastal & Hydraul Lab, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM Duncan.bryant@usace.army.mil RI Chang, Kuang-An/D-7556-2015 OI Chang, Kuang-An/0000-0003-3177-4896 FU National Sea Grant Program, National Oceanic and Atmospheric Administration, U.S. Department of Commerce [NA06OAR4170076]; NSF CBET [0637034]; International Research and Education in Engineering (IREE) program FX This study was supported by institutional grant NA06OAR4170076 to Texas A&M University from the National Sea Grant Program, National Oceanic and Atmospheric Administration, U.S. Department of Commerce. Travel Funds were provided from NSF CBET proposal number 0637034 for supplemental funding through the International Research and Education in Engineering (IREE) program. Thanks to Dr. Wernher Brevis, Bryan Alldredge, and Kate Hagan for their support in conducting the experiments. We would also like to thank to Dr. Gerhard Jirka for his support and time in the shallow water basin at the University of Karlsruhe. The study of environmental fluid mechanics was one of his passions and he made many contributions in this field. He will be missed. NR 23 TC 3 Z9 3 U1 1 U2 10 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 1567-7419 J9 ENVIRON FLUID MECH JI Environ. Fluid Mech. PD AUG PY 2012 VL 12 IS 4 BP 301 EP 319 DI 10.1007/s10652-012-9237-4 PG 19 WC Environmental Sciences; Mechanics; Meteorology & Atmospheric Sciences; Oceanography; Water Resources SC Environmental Sciences & Ecology; Mechanics; Meteorology & Atmospheric Sciences; Oceanography; Water Resources GA 973EJ UT WOS:000306338500001 ER PT J AU George, SG Slack, WT Hoover, JJ AF George, S. G. Slack, W. T. Hoover, J. J. TI A note on the fecundity of pallid sturgeon SO JOURNAL OF APPLIED ICHTHYOLOGY LA English DT Article ID MIDDLE MISSISSIPPI RIVER; SHOVELNOSE STURGEON; LIFE-HISTORY; REPRODUCTIVE STAGE; SCAPHIRHYNCHUS-ALBUS; GONADAL DEVELOPMENT; BODY-SIZE; AGE; BIOLOGY; GROWTH AB Fecundity was estimated for two pallid sturgeon, Scaphirhynchus albus, from the Lower Mississippi River (LMR). Sturgeon measured 827 and 886 mm fork length, weighed <3.2 kilograms and had 16 237 and 17 810 ova per kilogram of body mass (based on mean ovum density) with total fecundity estimates ranging from 43 357 to 58 913. Ovum size in the two sturgeon was 2.53.0 mm diameter. Pectoral fin ray sections showed distinct annuli and spawning bands. The smaller sturgeon was aged at 10 and the larger fish at 12 years. Spawning bands were present and suggest the smaller sturgeon first spawned at age 8 and the larger fish at age 9. When compared to published results, the data representing specimens from more northern populations suggest that pallid sturgeon from the LMR mature at comparable ages but at smaller sizes and have greater gonadal mass. These features and greater fecundity per mass unit (number of eggs per kilogram body weight) suggest that LMR pallid sturgeon populations exhibit greater potential for population growth and recovery than other populations with slower growth and lower fecundity. C1 [George, S. G.] USA, Corps Engineers, Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA. RP George, SG (reprint author), USA, Corps Engineers, Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA. EM Steven.G.George@usace.army.mil FU US Army Corps of Engineers Mississippi Valley Division (CEMVD); New Orleans District (CEMVN) FX P. Hartfield (United States Fish and Wildlife Service, Jackson, MS) and B. Reed (Louisiana Department of Wildlife and Fisheries, Lake Charles, Louisiana) provided specimens and information on the project area. Laboratory assistance was provided by L. W. Southern, J. P. Kirk and B. R. Lewis, who processed pectoral fin rays and estimated ages of the fish. B. Durham provided microscopy assistance. Pallid sturgeon studies in the Lower Mississippi River are funded by the US Army Corps of Engineers Mississippi Valley Division (CEMVD) and New Orleans District (CEMVN). Permission to publish was granted by the US Army Chief of Engineers. Our thanks to all of the above. NR 32 TC 4 Z9 4 U1 1 U2 11 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0175-8659 J9 J APPL ICHTHYOL JI J. Appl. Ichthyol. PD AUG PY 2012 VL 28 IS 4 BP 512 EP 515 DI 10.1111/j.1439-0426.2011.01931.x PG 4 WC Fisheries; Marine & Freshwater Biology SC Fisheries; Marine & Freshwater Biology GA 970OX UT WOS:000306142900004 ER PT J AU Beaver, KM Shutt, JE Vaughn, MG DeLisi, M Wright, JP AF Beaver, Kevin M. Shutt, J. Eagle Vaughn, Michael G. DeLisi, Matt Wright, John Paul TI Genetic Influences on Measures of Parental Negativity and Childhood Maltreatment: An Exploratory Study Testing for Gene x Environment Correlations SO JOURNAL OF CONTEMPORARY CRIMINAL JUSTICE LA English DT Article DE genetics; parenting; dopamine; environment; family AB Behavioral genetics research has revealed that approximately 25% of the variance in measures of the family environment, including parenting, is attributable to genetic factors. However, precisely which candidate genes are associated with the family environment is largely unknown. The current study addresses this gap in the literature by analyzing data drawn from the National Longitudinal Study of Adolescent Health. Results provide some evidence that three genes of the dopaminergic system ( Dopamine D2 receptor gene [DRD2], Dopamine D4 receptor gene [DRD4], and Dopamine transporter gene [DAT1]) are associated with variation in measures of maternal negativity, paternal negativity, and childhood maltreatment for Caucasian males. We speak to what these findings mean for criminological theory and research that focuses on family socialization as an important factor in the etiology of crime and related antisocial behaviors. C1 [Beaver, Kevin M.] Florida State Univ, Coll Criminol & Criminal Justice, Tallahassee, FL 32306 USA. [Shutt, J. Eagle] US Army, Ft Drum, NY USA. [Vaughn, Michael G.] St Louis Univ, Sch Social Work, St Louis, MO 63103 USA. [DeLisi, Matt] Iowa State Univ, Ames, IA USA. [Wright, John Paul] Univ Cincinnati, Cincinnati, OH USA. RP Beaver, KM (reprint author), Florida State Univ, Coll Criminol & Criminal Justice, 634 West Call St, Tallahassee, FL 32306 USA. EM kbeaver@fsu.edu RI Beaver, Kevin/B-4631-2013 NR 64 TC 3 Z9 3 U1 2 U2 4 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 1043-9862 EI 1552-5406 J9 J CONTEMP CRIM JUST JI J. Contemp. Crim. Justice PD AUG PY 2012 VL 28 IS 3 SI SI BP 273 EP 292 DI 10.1177/1043986212450220 PG 20 WC Criminology & Penology SC Criminology & Penology GA V35SH UT WOS:000209168000004 ER PT J AU Short, SS Stojadinovic, A Nissan, A Wainberg, Z Dhall, D Yao, K Bilchik, A AF Short, Scott S. Stojadinovic, Alexander Nissan, Aviram Wainberg, Zev Dhall, Deepti Yao, Kathy Bilchik, Anton TI Adjuvant treatment of early colon cancer with micrometastases: Results of a national survey SO JOURNAL OF SURGICAL ONCOLOGY LA English DT Article DE colon cancer; lymph node metastases; micrometastatic disease; adjuvant chemotherapy ID LYMPH-NODE MICROMETASTASES; OCCULT TUMOR-CELLS; COLORECTAL-CANCER; STAGE-II; PROGNOSTIC VALUE; DUKES STAGES; SURVIVAL; FLUOROURACIL; LEUCOVORIN; IMMUNOHISTOCHEMISTRY AB Background and Objectives Optimal adjuvant treatment for patients with Stage I/II colon cancer with micrometastases (MM) is unknown. Because there is no known adjuvant treatment-related benefit, we evaluated whether MM influenced treatment decisions. Method Review of a national survey from members of the SSO and ASCO. Results Of 602 survey responses, 305 (51%) stated that MM had significant prognostic value, 250 (42%) were unsure, and 47 (7%) did not believe that MM held prognostic value. Three hundred seventy-four (63%) would offer adjuvant therapy in the setting of MM, while 222 (37%) would not. Only 15% routinely performed IHC on lymph nodes. Medical oncologists were more likely to recommend adjuvant therapy compared to surgical oncologists (68% vs. 51%, P?=?0.001). Conclusions MM in colon cancer apparently influenced adjuvant treatment decisions absent known prognostic benefit. Prospective trials are needed to improve the selection of patients for systemic chemotherapy in early, node-negative colon cancer. J. Surg. Oncol. 2012; 106:119122. (c) 2012 Wiley Periodicals, Inc. C1 [Bilchik, Anton] Calif Oncol Res Inst, Los Angeles, CA 90404 USA. [Stojadinovic, Alexander] Walter Reed Army Med Ctr, Dept Surg, Div Surg Oncol, Washington, DC 20307 USA. [Nissan, Aviram] Rabin Med Ctr, Dept Surg, Petah Tiqwa, Israel. [Wainberg, Zev; Bilchik, Anton] Univ Calif Los Angeles, Los Angeles, CA USA. [Yao, Kathy] N Shore Univ, Chicago, IL USA. [Short, Scott S.; Dhall, Deepti; Bilchik, Anton] Cedars Sinai Med Ctr, Los Angeles, CA 90048 USA. RP Bilchik, A (reprint author), Calif Oncol Res Inst, 2336 Santa Monica Blvd,Suite 206, Los Angeles, CA 90404 USA. EM abilchik@mednet.ucla.edu FU National Cancer Institute [2RO1CA090848-05A2, 2R01CA090848-05A2]; Joyce E and Ben B Eisenberg Foundation; Hearst Foundation; Davidow Charitable Fund; Rod Fasone Memorial Cancer Fund; Sequoia Foundation for achievement in the arts and education; NIH FX This study was supported by grant 2RO1CA090848-05A2 from the National Cancer Institute and the Joyce E and Ben B Eisenberg Foundation, the Hearst Foundation, the Davidow Charitable Fund, the Rod Fasone Memorial Cancer Fund, Mrs. Ruth Weil, the Sequoia Foundation for achievement in the arts and education and Mrs. Marguerite Perkins Mautner.; Grant sponsor: NIH; Grant sponsor: National Cancer Institute; Grant number: 2R01CA090848-05A2; Grant sponsor: Joyce E and Ben B Eisenberg Foundation; Grant sponsor: Hearst Foundation; Grant sponsor: Davidow Charitable Fund; Grant sponsor: Rod Fasone Memorial Cancer Fund; Grant sponsor: Sequoia Foundation for Achievement in the Arts and Education. NR 26 TC 4 Z9 4 U1 0 U2 1 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0022-4790 J9 J SURG ONCOL JI J. Surg. Oncol. PD AUG PY 2012 VL 106 IS 2 BP 119 EP 122 DI 10.1002/jso.23057 PG 4 WC Oncology; Surgery SC Oncology; Surgery GA 971EY UT WOS:000306187700001 PM 22308106 ER PT J AU Cisney, ED Fernandez, S Hall, SI Krietz, GA Ulrich, RG AF Cisney, Emily D. Fernandez, Stefan Hall, Shannan I. Krietz, Gale A. Ulrich, Robert G. TI Examining the Role of Nasopharyngeal-associated Lymphoreticular Tissue (NALT) in Mouse Responses to Vaccines SO JOVE-JOURNAL OF VISUALIZED EXPERIMENTS LA English DT Article DE Infectious Diseases; Issue 66; Immunology; nasal vaccination; nasopharyngeal-associated lymphoreticular tissue; mouse; antibody; mucosal immunity; NALT ablation; NALT culture; NALT-deficient mice AB The nasopharyngeal-associated lymphoreticular tissues (NALT) found in humans, rodents, and other mammals, contribute to immunity in the nasal sinuses(1-3). The NALT are two parallel bell-shaped structures located in the nasal passages above the hard palate, and are usually considered to be secondary components of the mucosal-associated lymphoid system(4-6). Located within the NALT are discrete compartments of B and T lymphocytes interspersed with antigen-presenting dendritic cells(4,7,8). These cells are surrounded by an epithelial cell layer intercalated with M-cells that are responsible for antigen retrieval from the mucosal surfaces of the air passages(9,10). Naive lymphocytes circulating through the NALT are poised to respond to first encounters with respiratory pathogens(7). While NALT disappear in humans by the age of two years, the Waldeyer's Ring and similarly structured lymphatic organs continue to persist throughout life(6). In contrast to humans, mice retain NALT throughout life, thus providing a convenient animal model for the study of immune responses originating within the nasal sinuses(11). Cultures of single-cell suspensions of NALT are not practical due to low yields of mononuclear cells. However, NALT biology can be examined by ex vivo culturing of the intact organ, and this method has the additional advantage of maintaining the natural tissue structure. For in vivo studies, genetic knockout models presenting defects limited to NALT are not currently available due to a poor understanding of the developmental pathway. For example, while lymphotoxin-a knockout mice have atrophied NALT, the Peyer's patches, peripheral lymph nodes, follicular dendritic cells and other lymphoid tissues are also altered in these genetically manipulated mice(12,13). As an alternative to gene knockout mice, surgical ablation permanently eliminates NALT from the nasal passage without affecting other tissues. The resulting mouse model has been used to establish relationships between NALT and immune responses to vaccines(1,3). Serial collection of serum, saliva, nasal washes and vaginal secretions is necessary for establishing the basis of host responses to vaccination, while immune responses originating directly from NALT can be confirmed by tissue culture. The following procedures outline the surgeries, tissue culture and sample collection necessary to examine local and systemic humoral immune responses to intranasal (IN) vaccination. C1 [Cisney, Emily D.; Fernandez, Stefan; Hall, Shannan I.; Krietz, Gale A.; Ulrich, Robert G.] US Army Med Res Inst Infect Dis, Ft Detrick, MD 21701 USA. RP Ulrich, RG (reprint author), US Army Med Res Inst Infect Dis, Ft Detrick, MD 21701 USA. EM rulrich@bhsai.org FU Becton Dickinson Technologies FX Support was provided by Becton Dickinson Technologies. Views expressed in this submission are those of the authors and do not purport to reflect official policy of the U. S. Government. Research was conducted in compliance with the Animal Welfare Act and other federal statutes and regulations relating to animals and experiments involving animals and adheres to principles stated in the Guide for the Care and Use of Laboratory Animals, National Research Council, 1996. The facility where this research was conducted is fully accredited by the Association for Assessment and Accreditation of Laboratory Animal Care International. NR 14 TC 0 Z9 0 U1 0 U2 1 PU JOURNAL OF VISUALIZED EXPERIMENTS PI CAMBRIDGE PA 1 ALEWIFE CENTER, STE 200, CAMBRIDGE, MA 02140 USA SN 1940-087X J9 JOVE-J VIS EXP JI J. Vis. Exp. PD AUG PY 2012 IS 66 AR UNSP e3960 DI 10.3791/3960 PG 7 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA V36QC UT WOS:000209225000014 ER PT J AU Kanel, RL Tepe, V Ness, J Gratel, S AF Kanel, Robert L. Tepe, Victoria Ness, James Gratel, Stephen TI In Response to: "The ANAM Lacks Utility as a Diagnostic or Screening Tool for Concussion More Than 10 Days Following Injury," published in the February issue (Mil Med 2011; 177(2): 179-83) SO MILITARY MEDICINE LA English DT Letter C1 [Ness, James] US Mil Acad, West Point, NY 10996 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD AUG PY 2012 VL 177 IS 8 BP VI EP VII PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA V33OA UT WOS:000209026900002 PM 22934363 ER PT J AU Helmick, K Baugh, L Lattimore, T Goldman, S AF Helmick, Kathy Baugh, Laura Lattimore, Tracie Goldman, Sarah TI Traumatic Brain Injury: Next Steps, Research Needed, and Priority Focus Areas SO MILITARY MEDICINE LA English DT Article AB Traumatic brain injury (TBI) has been not only a major focus of concern during the recent conflicts in Afghanistan and Iraq, but also among our garrison service members. The prevalence of these injuries has compelled the nation and Congress to invest in the development of policies and programs that support evidence-based care for the full continuum of TBI, from mild (otherwise known as concussion) to severe and penetrating brain injuries. Although, the Department of Defense has made great strides in the areas of TBI clinical care, education, and research, there remains a great need to leverage scientific, policy, and clinical advancement to maximize care of the service member. The purpose of this article is to outline the 7 major areas of work currently being undertaken to help advance the field of TBI. The 7 areas include: (I) eliminating undetected mild traumatic brain injury through prompt early diagnosis, (2) ensuring force readiness and addressing cultural barriers, (3) improving collaborations with the Department of Veterans Affairs, other federal agencies, and academic and civilian organizations, (4) improving deployment-related assessments, (5) deploying effective treatments, (6) conducting military-relevant and targeted research, and (7) enhancing information technology systems. C1 [Helmick, Kathy] Def Ctr Excellence Psychol Hlth & Traumat Brain I, Silver Spring, MD 20910 USA. [Baugh, Laura] AFMSA SG30, AF SGE Attn Maj Baugh, Air Force Med Support Agcy, Washington, DC 20330 USA. [Lattimore, Tracie; Goldman, Sarah] US Army, Off Surg Gen, Rehabil & Reintegrat Div, Falls Church, VA 22041 USA. RP Helmick, K (reprint author), Def Ctr Excellence Psychol Hlth & Traumat Brain I, 1335 East West Highway, Silver Spring, MD 20910 USA. NR 7 TC 8 Z9 8 U1 0 U2 1 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD AUG PY 2012 VL 177 IS 8 SU S SI SI BP 86 EP 92 PG 7 WC Medicine, General & Internal SC General & Internal Medicine GA V33OB UT WOS:000209027000012 PM 22953445 ER PT J AU Lewis, PC Stewart, D Brown, W AF Lewis, Paul C. Stewart, Della Brown, William TI Deployment Experiences of Army Nurse Practitioners SO MILITARY MEDICINE LA English DT Article AB Army Nurse Practitioners (NPs) provide immediate and lifesaving care during combat operations. The most recent conflicts of Operation Iraqi Freedom and Operation Enduring Freedom have seen an increasing number of NP deployments. The uniqueness of these conflicts has also seen NPs being used in nontraditional roles. This study surveyed 50 Army NPs with deployment experience to explore and elucidate their clinical practices in a combat environment. Over 70% reported seeing greater than 11 patients a day with the top three diagnoses of musculoskeletal/soft tissue (noncombat), spinal pain (mechanical, sciatica), and gastrointestinal complaints. Over 74% reported having a physician available for collaboration, but 50% reported providing independent emergency care and 58% treating life-threatening injuries. The NPs in this study report standard credentialing privileges with most care falling within this realm. However, a few report nontraditional roles such as hospital admitting privileges. This study adds to the growing body of knowledge on NP practice in a combat environment, which shows increased decision making and advanced clinical skills. NPs are battlefield multipliers who bring additional skills and abilities to the combat environment. C1 [Lewis, Paul C.] Uniformed Serv Univ Hlth Sci, Grad Sch Nursing, Bethesda, MD 20814 USA. [Stewart, Della] Womack Army Med Ctr, Ft Bragg, NC 28310 USA. [Brown, William] Univ Virginia, Palmyra, VA 22963 USA. RP Lewis, PC (reprint author), Uniformed Serv Univ Hlth Sci, Grad Sch Nursing, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA. NR 11 TC 1 Z9 1 U1 0 U2 5 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD AUG PY 2012 VL 177 IS 8 BP 889 EP 893 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA V33OA UT WOS:000209026900004 PM 22934365 ER PT J AU Hakre, S Upshaw-Combs, DR Sanders-Buell, EE Scoville, SL Kuper, JD Jagodzinski, LL Bradfield, AN Davison, DC Calis, WG Owens, AB Michael, NL O'Connell, RJ Peel, SA Gardner, JW Thompson, ND Hu, DJ Kim, JH Tovanabutra, S Scott, PT Lafon, SG AF Hakre, Shilpa Upshaw-Combs, Donna R. Sanders-Buell, Eric E. Scoville, Stephanie L. Kuper, Joshua D. Jagodzinski, Linda L. Bradfield, Andrea N. Davison, Dinae C. Calis, William G. Owens, Angela B. Michael, Nelson L. O'Connell, Robert J. Peel, Sheila A. Gardner, John W. Thompson, Nicola D. Hu, Dale J. Kim, Jerome H. Tovanabutra, Sodsai Scott, Paul T. LaFon, Sandra G. CA Insulin Pen Investigation Team TI An Investigation of Bloodborne Pathogen Transmission Due to Multipatient Sharing of Insulin Pens SO MILITARY MEDICINE LA English DT Article AB On January 30, 2009, nursing staff at a military hospital in Texas reported that single-patient use insulin pens were used on multiple patients. An investigation was initiated to determine if patient-to-patient bloodborne transmission occurred from the practice. Human immunodeficiency virus (HIV), hepatitis B virus (HBV), and hepatitis C virus (HCV) testing was offered to patients hospitalized from August 2007 to January 2009 and prescribed insulin pen injections. Virus from HCV-infected patients' sera was sequenced and compared for relatedness. An anonymous survey was administered to nurses. Of 2,113 patients prescribed insulin pen injections, 1,501 (71%) underwent testing; 6 (0.4%) were HIV positive, 6 (0.4%) were hepatitis B surface antigen positive, and 56 (3.7%) had HCV antibody. No viral sequences from 10 of 28 patients with newly diagnosed and 12 of 28 patients with preexisting HCV infection were closely related. Of 54 nurses surveyed, 74% reported being trained on insulin pen use, but 24% believed nurses used insulin pens on more than one patient. We found no clear evidence of bloodborne pathogen transmission Training of hospital staff on correct use of insulin pens should be prioritized and their practices evaluated. Insulin pens should be more clearly labeled for single-patient use. C1 [Hakre, Shilpa] Henry M Jackson Fdn Adv Mil Med, US Mil HIV Res Program, Bethesda, MD 20817 USA. [Upshaw-Combs, Donna R.; Kuper, Joshua D.; Davison, Dinae C.] William Beaumont Army Med Ctr, El Paso, TX 79920 USA. [Sanders-Buell, Eric E.; Bradfield, Andrea N.; Tovanabutra, Sodsai] Henry M Jackson Fdn Adv Mil Med, US Mil HIV Res Program, Silver Spring, MD 20910 USA. [Scoville, Stephanie L.] US Army Publ Hlth Command, Prevent Med Residency Program, Silver Spring, MD 20910 USA. [Jagodzinski, Linda L.; Peel, Sheila A.] Walter Reed Army Inst Res, HIV Diagnost & Reference Lab, US Mil HIV Res Program, Rockville, MD 20850 USA. [Calis, William G.] Moncrief Army Community Hosp, Fort Jackson, SC 29207 USA. [Owens, Angela B.] Keaki Technol LLC, US Army Publ Hlth Command, Ft Sam Houston, TX 78234 USA. [Michael, Nelson L.; O'Connell, Robert J.; Kim, Jerome H.; Scott, Paul T.] Walter Reed Army Inst Res, US Mil HIV Res Program, Bethesda, MD 20817 USA. [Gardner, John W.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [Thompson, Nicola D.; Hu, Dale J.] Ctr Dis Control & Prevent, Atlanta, GA USA. [LaFon, Sandra G.] 1st Armored Div, El Paso, TX 79918 USA. RP Hakre, S (reprint author), Henry M Jackson Fdn Adv Mil Med, US Mil HIV Res Program, 6720-A Rockledge Dr,Suite 400, Bethesda, MD 20817 USA. FU William Beaumont Army Medical Center; Henry M. Jackson Foundation; U.S. Army Public Health Command FX This investigation would not have been possible without the patient contact and notification efforts of the Insulin Pen Investigation Team members, Mr. Bruce Gramlich, CPT Billy McPherson, CPT Michael Swanhart, MAJ Victoria Prehn, and CPT Alfreda Ritter. We thank MAJ Christopher Perdue at the Armed Forces Health Surveillance Center for his assistance in obtaining archived medical encounter records for all patients in our cohort. We are grateful for laboratory assistance from Ms. Ying Liu and sample processing efforts of Mr. J. Connor Eggleston (U.S. Military HIV Research Program). We thank Mrs. Faye Raye at the Texas Department of Health Services Vital Statistics Fraud Unit for extracting cause of death records. We thank Drs. Philip Spradling and Joseph Perz for their review of the manuscript and Dr. Yuri Khudyakov for his review of the HCV molecular characterization results from the investigation (Centers for Disease Control and Prevention). The investigation, part of the response to the discovery of the insulin pen misuse, was funded by the William Beaumont Army Medical Center, the Henry M. Jackson Foundation, and the U.S. Army Public Health Command. NR 37 TC 5 Z9 5 U1 1 U2 3 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD AUG PY 2012 VL 177 IS 8 BP 930 EP 938 PG 9 WC Medicine, General & Internal SC General & Internal Medicine GA V33OA UT WOS:000209026900012 PM 22934373 ER PT J AU Im, EE Stewart, IJ Morrow, BD Tilley, MA Heegard, KD Aden, JK Chung, KK Cotant, CL AF Im, Ellen E. Stewart, Ian J. Morrow, Benjamin D. Tilley, Molly A. Heegard, Kelly D. Aden, James K. Chung, Kevin K. Cotant, Casey L. TI Retrospective Review of Serum Creatinine and Creatinine-Based Measures of Estimated Glomerular Filtration Rate in an Amputee Population SO MILITARY MEDICINE LA English DT Review AB A variety of equations are used to estimate glomerular filtration rate (eGFR). These formulas have never been validated in the setting of traumatic amputation. In this retrospective study involving 255 military personnel with traumatic amputations at a single outpatient center, muscle mass lost was estimated using percentage of estimated body weight lost (% EBWL). Serum creatinine (Scr) and eGFR by the Modification of Diet in Renal Disease (MDRD) and Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equations were compared to % EBWL for each patient. The average Scr for the group studied was also compared with a cohort matched for age, sex, and race from the Third National Health and Nutrition Examination Survey (NHANES 111). Percentage EBWL correlated significantly with Scr (R-2 = 0.095, p < 0.0001), eGFR by MDRD (R-2 = 0.077, p < 0.0001), and eGFR by CKD-EPI (R-2 = 0.074, p < 0.0001). The average Scr was significantly lower than a similar population from NHANES III (0.83 +/- 0.137 mg/dL vs. 1.14 +/- 0.127 mg/dL, p < 0.0001). Percentage EBWL has a significant correlation with Scr and eGFR by both the MDRD and CKD-EPI equations. Furthermore, patients with traumatic amputation have significantly lower Scr values than the general population. Creatinine-based estimators of GFR may overestimate renal function in the setting of traumatic amputation. C1 [Im, Ellen E.; Stewart, Ian J.; Morrow, Benjamin D.; Tilley, Molly A.; Heegard, Kelly D.; Cotant, Casey L.] San Antonio Mil Med Ctr, Lackland AFB, TX 78236 USA. [Aden, James K.; Chung, Kevin K.] US Army Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Im, EE (reprint author), San Antonio Mil Med Ctr, 2200 Bergquist Dr,Suite 1,59MDOS SGO5K, Lackland AFB, TX 78236 USA. NR 20 TC 4 Z9 4 U1 2 U2 3 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD AUG PY 2012 VL 177 IS 8 BP 952 EP 956 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA V33OA UT WOS:000209026900015 PM 22934376 ER PT J AU Peik, SM Pollack, KM Canham-Chervak, M Hauret, KG Baker, SP AF Peik, Samuel M. Pollack, Keshia M. Canham-Chervak, Michelle Hauret, Keith G. Baker, Susan P. TI Injuries to Deployed US Army Soldiers Involved in HMMWV Crashes, 2002-2006 SO MILITARY MEDICINE LA English DT Article AB Highly mobile multipurpose wheeled vehicle (HMMWV or Humvee) crashes present an important issue for the U.S. military. The aim of this study was to provide a descriptive analysis of occupants of military motor vehicle (MMV) crashes involving HMMWVs that occurred among deployed U.S. Army Soldiers. Crash-related data were collected from the U.S. Army Combat Readiness/Safety Center on MMV crashes among active duty Army personnel between 1999 and 2006. Records for 964 occupants with injuries from HMMWV crashes were analyzed, which represented 52% of the total occupants of MMV crashes. A significant association was observed between injury and engagement in combat, odds ratio 1.49 (1.03, 2.16). The risk of injury was greatest for gunners, odds ratio 2.37 (1.43, 3.92), and injury cost related to the crash was significantly related to prior deployment status (p < 0.001) and role of Soldier in the vehicle (Operator p = 0.005, Gunner p = 0.003). There was also a decrease over time in the number of crashes resulting in injury (p < 0.001). These data support the development of interventions that address the specific risks detailed, including the use of combat simulation training, increased protection for vulnerable positions, and enforcement of safety regulations. C1 [Peik, Samuel M.] Walter Reed Army Inst Res, Div Prevent Med, Silver Spring, MD 20910 USA. [Pollack, Keshia M.; Baker, Susan P.] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Hlth Policy & Management, Baltimore, MD 21205 USA. [Pollack, Keshia M.; Baker, Susan P.] Johns Hopkins Ctr Injury Res & Policy, Johns Hopkins Bloomberg Sch Publ Hlth, Baltimore, MD 21205 USA. [Canham-Chervak, Michelle; Hauret, Keith G.] US Army Publ Hlth Command, Injury Prevent Program, Aberdeen Proving Ground, MD 21010 USA. RP Peik, SM (reprint author), Walter Reed Army Inst Res, Div Prevent Med, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. FU Centers for Disease Control and Prevention [5R49CE001507]; Defense Safety Oversight Council through Concurrent Technologies Corporation FX This publication was supported in part by Grant Number 5R49CE001507 from the Centers for Disease Control and Prevention to the Johns Hopkins Center for Injury Research and Policy. The research was also supported by the Defense Safety Oversight Council through Concurrent Technologies Corporation in June 2007. NR 13 TC 0 Z9 0 U1 0 U2 0 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD AUG PY 2012 VL 177 IS 8 BP 963 EP 969 PG 7 WC Medicine, General & Internal SC General & Internal Medicine GA V33OA UT WOS:000209026900017 PM 22934378 ER PT J AU Hsiao, MS Cameron, KL Huh, J Hsu, JR Benigni, M Whitener, JC Owens, BD AF Hsiao, Mark S. Cameron, Kenneth L. Huh, Jeannie Hsu, Joseph R. Benigni, Matthew Whitener, JoAnna C. Owens, Brett D. TI Clavicle Fractures in the United States Military: Incidence and Characteristics SO MILITARY MEDICINE LA English DT Article AB Background: Although it is generally known that clavicle fractures represent a common injury of the shoulder girdle in the general population, the true incidence in the active duty military population is unknown. Given the implications for such injuries on the ability to perform occupation-specific tasks, determining the incidence in the U.S. military population is worthwhile. The purpose of this study was to determine the incidence of clavicle fractures in the U.S. military and to identify any demographic risk factors for injury. Methods: We performed a query of the Defense Medical Epidemiology Database with the code from the International Classification of Diseases, Ninth Revision, for clavicle fractures for the years 1999 through 2008. An overall injury incidence was calculated, in addition to multivariate analysis, to determine independent risk factors among the following demographic considerations: sex, race, branch of military service, rank, and age. Results: During the study period, a total of 12,514 clavicle fractures were documented among an at-risk population of 13,770,767 person-years for an incidence rate (IR) of 0.91 per 1,000 person-years in the U.S. Military. Males, when compared with females, were more than twice as likely to sustain a clavicle fracture OR ratios [IRR], 2.30; 95% confidence intervals [CI], 2.12-2.49). The peak incidence of clavicle fractures occurred in the age groups of <20 and 20 to 24. Compared to black service members, the white service members were associated with significantly higher rate of clavicle fractures (IRR, 2.45; 95% CI, 2.28-2.63). The service members serving in the Marine Corps were associated with a higher IR of clavicle fractures when compared to those in the Navy (IRR, 1.44; 95% CI, 1.35-1.53). Junior enlisted service members were 34% as likely to sustain a clavicle fracture when compared to senior officers (IRR, 1.46; 95% CI, 1.34-1.60 and IRR, 1.12; 95% CI, 0.99-1.28, respectively). Conclusions: The incidence of clavicle fractures among U.S. military personnel (0.908 per 1,000 person-years) is higher than previous epidemiological reports. C1 [Hsiao, Mark S.] William Beaumont Army Med Ctr, El Paso, TX 79920 USA. [Cameron, Kenneth L.; Owens, Brett D.] Keller Army Hosp, Dept Orthopaed Surg, Dept Orthopaed Res, West Point, NY 10996 USA. [Huh, Jeannie; Hsu, Joseph R.] Brooke Army Med Ctr, San Antonio Mil Med Ctr, Dept Orthopaed Surg & Rehabil, Ft Sam Houston, TX 78234 USA. [Benigni, Matthew; Whitener, JoAnna C.] US Mil Acad, Dept Math Sci, West Point, NY 10996 USA. RP Hsiao, MS (reprint author), William Beaumont Army Med Ctr, 5005 North Piedras St,RM 3C49, El Paso, TX 79920 USA. NR 28 TC 3 Z9 3 U1 0 U2 0 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD AUG PY 2012 VL 177 IS 8 BP 970 EP 974 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA V33OA UT WOS:000209026900018 PM 22934379 ER PT J AU Hile, DC Morgan, AR Laselle, BT Bothwell, JD AF Hile, David C. Morgan, Andrew R. Laselle, Brooks T. Bothwell, Jason D. TI Is Point-of-Care Ultrasound Accurate and Useful in the Hands of Military Medical Technicians? A Review of the Literature SO MILITARY MEDICINE LA English DT Review AB Over the past decade, point-of-care ultrasound (US) use by nonphysician providers has grown substantially. The purpose of this article is to (1) summarize the literature evaluating military medics' facility at US, (2) more clearly define the potential utility of military prehospital US technology, and (3) lay a pathway for future research of military prehospital US. The authors performed a keyword search using multiple search engines. Each author independently reviewed the search results and evaluated the literature for inclusion. Of 30 studies identified, five studies met inclusion criteria. The applications included evaluation of cardiac activity, pneumothorax evaluation, and fracture evaluation. Additionally, a descriptive study demonstrated distribution of US exam types during practical use by Army Special Forces Medical Sergeants. No studies evaluated retention of skills over prolonged periods. Multiple studies demonstrate the feasibility of training military medics in US. Even under austere conditions, the majority of studies conclude that medic can perform US with a high degree of accuracy. Lessons learned from these studies tend to support continued use of US in out-of-hospital settings and exploration of the optimal curriculum to introduce this skill. C1 [Hile, David C.; Laselle, Brooks T.; Bothwell, Jason D.] Joint Base Lewis McChord, Madigan Healthcare Syst, Tacoma, WA 98431 USA. [Morgan, Andrew R.] Womack Army Med Ctr, Ft Bragg, NC 28307 USA. RP Hile, DC (reprint author), Joint Base Lewis McChord, Madigan Healthcare Syst, Bldg 9040,Fitzsimmons Dr, Tacoma, WA 98431 USA. NR 20 TC 1 Z9 1 U1 0 U2 2 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD AUG PY 2012 VL 177 IS 8 BP 983 EP 987 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA V33OA UT WOS:000209026900020 PM 22934381 ER PT J AU Harcke, HT Rooks, VJ AF Harcke, H. Theodore Rooks, Veronica J. TI Sonographic Localization and Management of Metallic Fragments: A Report of Five Cases SO MILITARY MEDICINE LA English DT Article AB Ultrasound was used as adjunct to radiographic imaging in the assessment and management of metallic fragments in five cases encountered in forward-deployed military facilities. Although metallic fragments are usually seen well on radiographs, ultrasound can add details of the surrounding soft-tissue structures and clarify location. Portable handheld units are well suited for studies when probe selection and equipment adjustments are correct. In selected cases, ultrasound information can favorably influence case management. C1 [Harcke, H. Theodore] Armed Forces Inst Pathol, Washington, DC 20306 USA. [Harcke, H. Theodore; Rooks, Veronica J.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [Rooks, Veronica J.] Tripler Army Med Ctr, Honolulu, HI 96859 USA. RP Harcke, HT (reprint author), Armed Forces Inst Pathol, 6900 Georgia Ave, Washington, DC 20306 USA. NR 15 TC 1 Z9 1 U1 0 U2 0 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD AUG PY 2012 VL 177 IS 8 BP 988 EP 992 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA V33OA UT WOS:000209026900021 PM 22934382 ER PT J AU Kennedy, AB Westerink, JJ Smith, JM Hope, ME Hartman, M Taflanidis, AA Tanaka, S Westerink, H Cheung, KF Smith, T Hamann, M Minamide, M Ota, A Dawson, C AF Kennedy, Andrew B. Westerink, Joannes J. Smith, Jane M. Hope, Mark E. Hartman, Michael Taflanidis, Alexandros A. Tanaka, Seizo Westerink, Hans Cheung, Kwok Fai Smith, Tom Hamann, Madeleine Minamide, Masashi Ota, Aina Dawson, Clint TI Tropical cyclone inundation potential on the Hawaiian Islands of Oahu and Kauai SO OCEAN MODELLING LA English DT Article DE Hurricanes; Water waves; Wave runup; Storm surge; Storm inundation; Hurricane Iniki; Hawaii ID RUNUP AB The lack of a continental shelf in steep volcanic islands leads to significant changes in tropical cyclone inundation potential, with wave setup and runup increasing in importance and wind driven surge decreasing when compared to more gently-sloped mainland regions. This is illustrated through high resolution modeling of waves, surge, and runup on the Hawaiian Islands of Oahu and Kauai. A series of hurricane waves and water levels were computed using the SWAN + ADCIRC models for a suite of 643 synthetic storm scenarios, while local wave runup was evaluated along a series of 1D transects using the phase-resolving model Bouss1D. Waves are found to be an extremely important component of the inundation, both from breaking wave forced increases in storm surge and also from wave runup over the relatively steep topography. This is clear in comparisons with debris lines left by Hurricane Iniki on the Island of Kauai, where runup penetration is much greater than still water inundation in most instances. The difference between steeply-sloping and gently-sloping topographies was demonstrated by recomputing Iniki with the same landfall location as Hurricane Katrina in Louisiana. Surge was greatly increased for the mild-slope Iniki-in-Louisiana case, while pure wind surge for Iniki-in-Kauai was very small. For the entire suite of storms, maxima on Kauai show predicted inundation largely confined to a narrow coastal strip, with few locations showing more than a few hundred meters of flooding from the shoreline. As expected, maximum flooded areas for the 643 storms were somewhat greater than the Iniki inundation. Oahu has significantly more low-lying land compared to Kauai, and consequently hypothetical tropical cyclone landfalls show much more widespread inundation. Under direct impact scenarios, there is the potential for much of Honolulu and most of Waikiki to be inundated, with both still water surge and wave runup contributing. Other regions of Oahu show inundation confined to a more narrow coastal strip, although there is still much infrastructure at risk. Even for very strong storms in Oahu and Kauai, maximum still water surge is relatively small, and does not exceed 3 m in any storm modeled. In contrast, hurricane waves several kilometers from shore regularly exceed 10 m due to the lack of a continental shelf. (C) 2012 Elsevier Ltd. All rights reserved. C1 [Kennedy, Andrew B.; Westerink, Joannes J.; Hope, Mark E.; Hartman, Michael; Taflanidis, Alexandros A.; Tanaka, Seizo; Westerink, Hans; Hamann, Madeleine] Univ Notre Dame, Dept Civil Engn & Geol Sci, Notre Dame, IN 46556 USA. [Smith, Jane M.] USA, Coastal & Hydraul Lab, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. [Cheung, Kwok Fai] Univ Hawaii Manoa, Dept Ocean & Resources Engn, Honolulu, HI 96822 USA. [Smith, Tom] USA, Corps Engineers, Ft Shafter, HI 96858 USA. [Tanaka, Seizo; Hamann, Madeleine; Minamide, Masashi] Univ Tokyo, Fac Engn, Dept Civil Engn, Bukkyo Ku, Tokyo 1138656, Japan. [Dawson, Clint] Univ Texas Austin, Dept Aerosp Engn & Engn Mech, WR Woolrich Labs, Austin, TX 78712 USA. RP Kennedy, AB (reprint author), Univ Notre Dame, Dept Civil Engn & Geol Sci, Notre Dame, IN 46556 USA. EM andrew.kennedy@nd.edu RI Kennedy, Andrew/E-4746-2011; Taflanidis, Alexandros/A-3393-2012; OI Kennedy, Andrew/0000-0002-7254-1346; Taflanidis, Alexandros/0000-0002-9784-7480 FU US Army Corps of Engineers FX This work was funded under the Surge and Wave Island Modeling Studies under the Field Data Collection Program of the US Army Corps of Engineers. Permission to publish was granted by the Chief of Engineers. NR 24 TC 20 Z9 20 U1 3 U2 18 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1463-5003 J9 OCEAN MODEL JI Ocean Model. PD AUG PY 2012 VL 52-53 BP 54 EP 68 DI 10.1016/j.ocemod.2012.04.009 PG 15 WC Meteorology & Atmospheric Sciences; Oceanography SC Meteorology & Atmospheric Sciences; Oceanography GA 970YU UT WOS:000306169200004 ER PT J AU Ligda, JP Schuster, BE Wei, Q AF Ligda, J. P. Schuster, B. E. Wei, Q. TI Transition in the deformation mode of nanocrystalline tantalum processed by high-pressure torsion SO SCRIPTA MATERIALIA LA English DT Article DE Nanoindentation; Nanocrystalline metal; Shear bands; Microcompression; Severe plastic deformation ID ULTRAFINE GRAIN SIZES; MECHANICAL-PROPERTIES; ELASTIC-MODULUS; SHEAR BANDS; BEHAVIOR; MICROSTRUCTURE; INDENTATION; COMPRESSION; IRON; METHODOLOGY AB We present quasi-static room temperature compression and nanoindentation data for nanocrystalline and ultrafine grained tantalum processed by high-pressure torsion. Because bulk samples possess an inherent gradient in properties, microstructures were characterized using site-specific transmission electron microscopy and synchrotron X-ray diffraction. Nanocrystalline Ta shows appreciable homogeneous plastic deformation in compression; however, specimens with the smallest grain sizes exhibit localized plastic deformation via shear bands. Microstructural changes associated with this transition in deformation mode are discussed. (C) 2012 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved. C1 [Ligda, J. P.] Univ N Carolina, PhD Program Nanoscale Sci & Technol, Charlotte, NC 28223 USA. [Schuster, B. E.] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. [Wei, Q.] Univ N Carolina, Dept Mech Engn, Charlotte, NC 28223 USA. RP Ligda, JP (reprint author), Univ N Carolina, PhD Program Nanoscale Sci & Technol, Charlotte, NC 28223 USA. EM jligda@uncc.edu RI Wei, Qiuming/B-7579-2008 FU US Army Research Laboratory [W911QX-06-C-0124, W911QX-08-C-0073]; US DOE [DE-AC02-06CH11357] FX We would like to thank Dr. Ruslan Valiev for performing the HPT on the Ta disk and Dr. Shailendra Joshi for discussions on grain rotation theory. We would also like to extend our gratitude to Brady Butler for help with the TEM analysis. Q.W. would like to acknowledge support from the US Army Research Laboratory under contracts Nos. W911QX-06-C-0124 and W911QX-08-C-0073. Use of the Advanced Photon Source, an Office of Science User Facility operated for the US Department of Energy (DOE) Office of Science by Argonne National Laboratory, was supported by the US DOE under contract No. DE-AC02-06CH11357. NR 24 TC 9 Z9 9 U1 0 U2 33 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 1359-6462 J9 SCRIPTA MATER JI Scr. Mater. PD AUG PY 2012 VL 67 IS 3 BP 253 EP 256 DI 10.1016/j.scriptamat.2012.04.031 PG 4 WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Science & Technology - Other Topics; Materials Science; Metallurgy & Metallurgical Engineering GA 972DL UT WOS:000306256600008 ER PT J AU Scott, AM Petrova, T Hill, F Leszczynski, J AF Scott, A. Michalkova Petrova, T. Hill, F. Leszczynski, J. TI Density functional theory study of interactions of cyclotrimethylene trinitramine (RDX) and triacetone triperoxide (TATP) with metal-organic framework (IRMOF-1(Be)) SO STRUCTURAL CHEMISTRY LA English DT Article DE IRMOF-1; RDX; TATP; DFT ID AB-INITIO; MOLECULAR SIMULATIONS; HYDROGEN STORAGE; FORCE-FIELD; ADSORPTION; MECHANISM; DESIGN; MOF-5; DIFFUSION; BINDING AB We performed a density functional study of the interactions of 1,3,5-trinitro-s-triazine (RDX) and triacetone triperoxide (TATP) with small fragments of isoreticular crystalline metal-organic frameworks having beryllium as connector metal center (IRMOF-1(Be)). The influence of different metal centers of the connector was evaluated. For particular IRMOF-1 clusters, used small IRMOF-1(Zn) fragments are reported to have higher binding affinity than such components of IRMOF-1(Be), and their interactions with TATP are favored compared with the RDX systems. The binding efficiency is also influenced by the presence of linkers. One benzene linker connected with a Be-O-C cluster was found to have the lowest binding energy for the target molecules when compared with larger fragments containing more linkers. Binding with IRMOF-1 fragments leads to polarization of RDX and TATP. The said effect is found to be larger for the TATP systems. C1 [Scott, A. Michalkova; Hill, F.; Leszczynski, J.] USA, Engineer Res & Dev Ctr ERDC, Vicksburg, MS 39180 USA. [Scott, A. Michalkova; Petrova, T.; Leszczynski, J.] Jackson State Univ, Dept Chem, Interdisciplinary Nanotox Ctr, Jackson, MS 39217 USA. RP Scott, AM (reprint author), USA, Engineer Res & Dev Ctr ERDC, Vicksburg, MS 39180 USA. EM andrea.m.scott@usace.army.mil FU NSF [0730186]; Division of Materials Science and Engineering, Office of Basic Energy Science of the US Department of Energy FX This study was facilitated by the NSF grant EXP-LA no. 0730186. This study at ORNL was performed under the auspices of the Division of Materials Science and Engineering, Office of Basic Energy Science of the US Department of Energy. The tests described and the resulting data presented herein, unless otherwise noted, were obtained from research conducted under the Environmental Quality Technology Program of the United States Army Corps of Engineers by the USAERDC. The authors acknowledge the permission granted by the Chief of Engineers to publish this information. NR 57 TC 1 Z9 1 U1 1 U2 26 PU SPRINGER/PLENUM PUBLISHERS PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1040-0400 EI 1572-9001 J9 STRUCT CHEM JI Struct. Chem. PD AUG PY 2012 VL 23 IS 4 BP 1143 EP 1154 DI 10.1007/s11224-011-9936-3 PG 12 WC Chemistry, Multidisciplinary; Chemistry, Physical; Crystallography SC Chemistry; Crystallography GA 971PC UT WOS:000306215300019 ER PT J AU Cornejo, A Sahar, DE Stephenson, SM Chang, SL Nguyen, S Guda, T Wenke, JC Vasquez, A Michalek, JE Sharma, R Krishnegowda, NK Wang, HT AF Cornejo, Agustin Sahar, David E. Stephenson, Stacy M. Chang, Shiliang Nguyen, Son Guda, Teja Wenke, Joseph C. Vasquez, Amanda Michalek, Joel E. Sharma, Ramaswamy Krishnegowda, Naveen K. Wang, Howard T. TI Effect of Adipose Tissue-Derived Osteogenic and Endothelial Cells on Bone Allograft Osteogenesis and Vascularization in Critical-Sized Calvarial Defects SO TISSUE ENGINEERING PART A LA English DT Article ID MESENCHYMAL STEM-CELLS; PROGENITOR CELLS; ENGINEERED BONE; NEOVASCULARIZATION; RECONSTRUCTION; MODEL; OSTEOBLASTS; COCULTURES; PERIOSTEUM; OUTGROWTH AB The use of processed bone allograft to repair large osseous defects of the skull has been limited, given that it lacks the osteogenic cellularity and intrinsic vascular supply which are essential elements for successful graft healing and, at the same time, the areas to be targeted through tissue-engineering applications. In this study, we investigated the effect of predifferentiated rat adipose tissue-derived osteoblastic cells (OBs) and endothelial cells (ECs) on calvarial bone allograft healing and vascularization using an orthotopic critical-sized calvarial defect model. For this purpose, thirty-seven 8 mm critical calvarial defects in Lewis rats were treated with bone allografts seeded with no cells, undifferentiated adipose tissue-derived stem cells (ASC), OBs, ECs, and OBs and ECs simultaneously. After 8 weeks, the bone volume and mineral density were calculated using microcomputed tomography and the microvessel formation using immunohistochemical staining and imaging software. The amount of bone within the 8mm defect was significantly higher for the allografts treated with ECs compared with the allografts treated with OBs (p = 0.05) and simultaneously with the two cell lineages (p = 0.02). There were no significant differences in bone formation between the latter two groups and the control groups (allografts treated with no cells and undifferentiated ASC). There were no significant differences in bone mineral density among the groups. The amount of microvessels was significantly higher in the group treated with ECs relative to all groups (p= < 0.05). Our results show that the implantation of ASC-derived ECs improves the vascularization of calvarial bone allografts at 8 weeks after treatment. This cell-based vascularization strategy can be used to improve the paucity of perfusion in allogenic bone implants. However, in this study, the treatment of allografts with OBs alone or in combination with ECs did not support bone formation or vascularization. C1 [Cornejo, Agustin; Sahar, David E.; Stephenson, Stacy M.; Chang, Shiliang; Nguyen, Son; Vasquez, Amanda; Krishnegowda, Naveen K.; Wang, Howard T.] Univ Texas Hlth Sci Ctr San Antonio, Div Plast & Reconstruct Surg, San Antonio, TX 78229 USA. [Guda, Teja; Wenke, Joseph C.] USA, Inst Surg Res, Extrem Trauma & Regenerat Med Task Area, Houston, TX USA. [Michalek, Joel E.] Univ Texas Hlth Sci Ctr San Antonio, Dept Epidemiol & Biostat, San Antonio, TX 78229 USA. [Sharma, Ramaswamy] Univ Texas Hlth Sci Ctr San Antonio, Dept Cellular & Struct Biol, San Antonio, TX 78229 USA. RP Wang, HT (reprint author), Univ Texas Hlth Sci Ctr San Antonio, Div Plast & Reconstruct Surg, 7703 Floyd Curl Dr, San Antonio, TX 78229 USA. EM wanght@uthscsa.edu RI Guda, Teja/A-7286-2009 OI Guda, Teja/0000-0002-3218-2916 FU National Endowment for Plastic Surgery FX This work was supported by a grant from the National Endowment for Plastic Surgery. NR 49 TC 22 Z9 22 U1 0 U2 7 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1937-3341 J9 TISSUE ENG PT A JI Tissue Eng. Part A PD AUG PY 2012 VL 18 IS 15-16 BP 1552 EP 1561 DI 10.1089/ten.tea.2011.0515 PG 10 WC Cell & Tissue Engineering; Biotechnology & Applied Microbiology; Cell Biology SC Cell Biology; Biotechnology & Applied Microbiology GA 995HP UT WOS:000307999100003 PM 22440012 ER PT J AU Forsberg, LS Abshire, TG Friedlander, A Quinn, CP Kannenberg, EL Carlson, RW AF Forsberg, L. Scott Abshire, Teresa G. Friedlander, Arthur Quinn, Conrad P. Kannenberg, Elmar L. Carlson, Russell W. TI Localization and structural analysis of a conserved pyruvylated epitope in Bacillus anthracis secondary cell wall polysaccharides and characterization of the galactose-deficient wall polysaccharide from avirulent B-anthracis CDC 684 SO GLYCOBIOLOGY LA English DT Article DE Bacillus anthracis; cell wall; polysaccharide; pyruvylation; structure ID CEREUS STRAINS; ACID; SURFACE; IDENTIFICATION; SPECTROSCOPY; PROTEINS; ACETAL; CONFIGURATION; ELUCIDATION; DERIVATIVES AB Bacillus anthracis CDC 684 is a naturally occurring, avirulent variant and close relative of the highly pathogenic B. anthracis Vollum. Bacillus anthracis CDC 684 contains both virulence plasmids, pXO1 and pXO2, yet is non-pathogenic in animal models, prompting closer scrutiny of the molecular basis of attenuation. We structurally characterized the secondary cell wall polysaccharide (SCWP) of B. anthracis CDC 684 (Ba684) using chemical and NMR spectroscopy analysis. The SCWP consists of a HexNAc trisaccharide backbone having identical structure as that of B. anthracis Pasteur, Sterne and Ames, -> 4)-beta-d-ManpNAc-(1 -> 4)-beta-d-GlcpNAc-(1 -> 6)-alpha-d-GlcpNAc-(1 ->. Remarkably, although the backbone is fully polymerized, the SCWP is the devoid of all galactosyl side residues, a feature which normally comprises 50% of the glycosyl residues on the highly galactosylated SCWPs from pathogenic strains. This observation highlights the role of defective wall assembly in virulence and indicates that polymerization occurs independently of galactose side residue attachment. Of particular interest, the polymerized Ba684 backbone retains the substoichiometric pyruvate acetal, O-acetate and amino group modifications found on SCWPs from normal B. anthracis strains, and immunofluorescence analysis confirms that SCWP expression coincides with the ability to bind the surface layer homology (SLH) domain containing S-layer protein extractable antigen-1. Pyruvate was previously demonstrated as part of a conserved epitope, mediating SLH-domain protein attachment to the underlying peptidoglycan layer. We find that a single repeating unit, located at the distal (non-reducing) end of the Ba684 SCWP, is structurally modified and that this modification is present in identical manner in the SCWPs of normal B. anthracis strains. These polysaccharides terminate in the sequence: (S)-4,6-O-(1-carboxyethylidene)-beta-d-ManpNAc-(1 -> 4)-[3-O-acetyl]-beta-d-GlcpNAc-(1 -> 6)-alpha-d-GlcpNH(2)-(1 ->. C1 [Forsberg, L. Scott; Kannenberg, Elmar L.; Carlson, Russell W.] Univ Georgia, Complex Carbohydrate Res Ctr, Athens, GA 30602 USA. [Abshire, Teresa G.] USA, Med Res Inst Infect Dis, Diagnost Syst Div, Frederick, MD 21702 USA. [Friedlander, Arthur] USA, Med Res Inst Infect Dis, Headquarters Div, Frederick, MD 21702 USA. [Quinn, Conrad P.] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. RP Forsberg, LS (reprint author), Univ Georgia, Complex Carbohydrate Res Ctr, 315 Riverbend Rd, Athens, GA 30602 USA. EM sforsb@ccrc.uga.edu FU National Institutes of Health [R21 AI076753]; Department of Energy [DE-FG02-09ER20097] FX This work was supported in part by National Institutes of Health (R21 AI076753 to R. W. C.). The Complex Carbohydrate Research Center was supported in part by Department of Energy (DE-FG02-09ER20097). NR 42 TC 18 Z9 19 U1 0 U2 7 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0959-6658 J9 GLYCOBIOLOGY JI Glycobiology PD AUG PY 2012 VL 22 IS 8 BP 1103 EP 1117 DI 10.1093/glycob/cws080 PG 15 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA 966FT UT WOS:000305823800008 PM 22556058 ER PT J AU Lu, Z Wang, WY Wang, C AF Lu, Zhuo Wang, Wenye Wang, Cliff TI Modeling and Performance Evaluation of Backoff Misbehaving Nodes in CSMA/CA Networks SO IEEE TRANSACTIONS ON MOBILE COMPUTING LA English DT Article DE CSMA/CA; random backoff; misbehaving nodes; performance gain; wireless networks ID DISTRIBUTED COORDINATION FUNCTION; WIRELESS NETWORKS; IEEE-802.11; THROUGHPUT; DELAY AB Backoff misbehavior, in which a wireless node deliberately manipulates its backoff time, can induce significant network problems, such as severe unfairness and denial of service. Although great progress has been made toward the design of countermeasures to backoff misbehavior, little attention has been focused on quantifying the gain of backoff misbehaviors. In this paper, to assess the gain that misbehaving nodes can obtain, we define and study two general classes of backoff misbehavior: continuous misbehavior, which keeps manipulating the backoff time unless it is disabled by countermeasures, and intermittent misbehavior, which tends to evade the detection of countermeasures by performing misbehavior sporadically. Our approach is to introduce a new performance metric, namely order gain, to characterize the performance benefits of misbehaving nodes in comparison to legitimate nodes in CSMA/CA-based wireless networks. We derive the order gains of both continuous and intermittent misbehaviors and further investigate the relation between our metric, order gain, and the throughput gain for a misbehaving node. We show that in IEEE 802.11 networks, the throughput ratio of a backoff misbehaving node to a legitimate node is either bounded above or proportional to the number of legitimate nodes. We use both simulations and experiments to validate our theoretical analysis and to further demonstrate the impact of a wide range of backoff misbehaviors on network performance in CSMA/CA-based wireless networks. C1 [Lu, Zhuo; Wang, Wenye] N Carolina State Univ, Dept Elect & Comp Engn, Raleigh, NC 27606 USA. [Wang, Cliff] USA, Res Off, Res Triangle Pk, NC 27709 USA. RP Lu, Z (reprint author), N Carolina State Univ, Dept Elect & Comp Engn, 890 Oval Dr, Raleigh, NC 27606 USA. EM zlu3@ncsu.edu; wwang@ncsu.edu; cliff.wang@us.army.mil FU US Army Research Office (ARO) [53435-CS-SR]; US National Science Foundation [CNS-0546289] FX An earlier version of this work was published in the 29th IEEE Conference on Computer Communications (INFOCOM 2010). This work was supported by the US Army Research Office (ARO) under Grant Number 53435-CS-SR and US National Science Foundation Career Award CNS-0546289. NR 24 TC 2 Z9 2 U1 0 U2 3 PU IEEE COMPUTER SOC PI LOS ALAMITOS PA 10662 LOS VAQUEROS CIRCLE, PO BOX 3014, LOS ALAMITOS, CA 90720-1314 USA SN 1536-1233 J9 IEEE T MOBILE COMPUT JI IEEE. Trans. Mob. Comput. PD AUG PY 2012 VL 11 IS 8 BP 1331 EP 1344 DI 10.1109/TMC.2011.164 PG 14 WC Computer Science, Information Systems; Telecommunications SC Computer Science; Telecommunications GA 964OO UT WOS:000305705800007 ER PT J AU Yenesew, A Akala, HM Twinomuhwezi, H Chepkirui, C Irungu, BN Eyase, FL Kamatenesi-Mugisha, M Kiremire, BT Johnson, JD Waters, NC AF Yenesew, Ably Akala, Hoseah M. Twinomuhwezi, Hannington Chepkirui, Carolyne Irungu, Beatrice N. Eyase, Fredrick L. Kamatenesi-Mugisha, Maud Kiremire, Bernard T. Johnson, Jacob D. Waters, Norman C. TI The antiplasmodial and radical scavenging activities of flavonoids of Erythrina burttii SO ACTA TROPICA LA English DT Article DE Erythrina burttii; Root bark; Leguminosae; Flavonoid; Isoflav-3-ene; 2-Arylbenzofuran; Malaria; Plasmodium falciparum; Plasmodium berghei; Radical scavenger; DPPH ID PARASITE PLASMODIUM-FALCIPARUM; ANTIOXIDANT ACTIVITY; ROOT BARK; STEM BARK; IN-VITRO; MALARIA; 2-ARYLBENZOFURAN; ABYSSINICA; ASSAY; VIVO AB The acetone extract of the root bark of Erythrina burttii showed in vitro antiplasmodial activity against the chloroquine-sensitive (D6) and chloroquine-resistant (W2) strains of Plasmodium falciparum with IC50 values of 0.97 +/- 0.2 and 1.73 +/- 0.5 mu g/ml respectively. The extract also had radical scavenging activity against 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical with an EC50 value of 12.0 mu g/ml. The isoflav-3-enes burttinol-A and burttinol-C, and the 2-arylbenzofuran derivative burttinol-D were identified as the most active antiplasmodial (IC50 <10 mu M) and free radical scavenging (EC50 ca. 10 mu m) principles. The acetone extract of E. burttii at 800 mg/kg/day, in a 4-day Plasmodium berghei ANKA suppressive test, showed in vivo antimalarial activity with 52% chemosuppression. In the same in vivo test, marginal activities were also observed for the extracts of the root and stem bark of Erythrina abyssinica and the root bark of Erythrina sacleuxii. (C) 2012 Elsevier B.V. All rights reserved. C1 [Yenesew, Ably; Twinomuhwezi, Hannington; Chepkirui, Carolyne] Univ Nairobi, Dept Chem, Nairobi 00100, Kenya. [Akala, Hoseah M.; Eyase, Fredrick L.; Johnson, Jacob D.] USA, Med Res Unit Kenya, Walter Reed Project, APO, AE 09831 USA. [Akala, Hoseah M.; Kamatenesi-Mugisha, Maud] Makerere Univ, Sch Biosci, Coll Nat Sci, Kampala, Uganda. [Twinomuhwezi, Hannington; Kiremire, Bernard T.] Makerere Univ, Dept Chem, Kampala, Uganda. [Irungu, Beatrice N.] Kenya Med Res Inst KEMRI, Ctr Tradit Med & Drug Res, Nairobi 00200, Kenya. [Waters, Norman C.] US Mil Acad, Dept Chem & Life Sci, New York, NY 10996 USA. RP Yenesew, A (reprint author), Univ Nairobi, Dept Chem, POB 30197, Nairobi 00100, Kenya. EM ayenesew@uonbi.ac.ke RI Derese, Solomon/H-5957-2016 OI Derese, Solomon/0000-0002-2640-3583 FU Natural Products Research Network for Eastern and Central Africa (NAPRECA); German Academic Exchange Service (DAAD) FX H.M.A. and H.T. are grateful to the Natural Products Research Network for Eastern and Central Africa (NAPRECA) and the German Academic Exchange Service (DAAD) for fellowship. Mr S.G. Mathenge is thanked for identification of the plant material. The opinions and assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the U.S. Department of the Army or the Department of Defense. NR 32 TC 11 Z9 12 U1 2 U2 8 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0001-706X J9 ACTA TROP JI Acta Trop. PD AUG PY 2012 VL 123 IS 2 BP 123 EP 127 DI 10.1016/j.actatropica.2012.04.011 PG 5 WC Parasitology; Tropical Medicine SC Parasitology; Tropical Medicine GA 960CE UT WOS:000305364800011 PM 22575309 ER PT J AU Bair, EH Simenhois, R Birkeland, K Dozier, J AF Bair, Edward H. Simenhois, Ron Birkeland, Karl Dozier, Jeff TI A field study on failure of storm snow slab avalanches SO COLD REGIONS SCIENCE AND TECHNOLOGY LA English DT Article DE Snow; Avalanche; Anticrack ID NEAR-INFRARED PHOTOGRAPHY; FRACTURE; MECHANISM; RELEASE; LAYERS; SPEED; TESTS AB Storm snow often avalanches before crystals metamorphose into faceted or rounded shapes, which typically occurs within a few days. We call such crystals nonpersistent, to distinguish them from snow crystals that persist within the snowpack for weeks or even months. Nonpersistent crystals can form weak layers or interfaces that are common sources of failure for avalanches. The anticrack fracture model emphasizes collapse and predicts that triggering is almost independent of slope angle, but this prediction has only been tested on persistent weak layers. In this study, dozens of stability tests show that both nonpersistent and persistent crystals collapse during failure, and that slope angle does not affect triggering (although slope angle determines whether collapse leads to an avalanche). Our findings suggest that avalanches in storm snow and persistent weak layers share the same failure mechanism described by the anticrack model, with collapse providing the fracture energy. Manual hardness measurements and near-infrared measurements of grain size sometimes showed thin weak layers of softer and larger crystals in storm snow, but often showed failures at interfaces marked by softer layers above and harder layers below. We suggest collapse often occurs in crystals at the bottom of the slab. Planar crystals such as sectored plates were often found in failure layers, suggesting they are especially prone to collapse. (C) 2012 Elsevier B.V. All rights reserved. C1 [Bair, Edward H.; Dozier, Jeff] USA, Cold Reg Res & Engn Lab, Corps Engineers, Hanover, NH 03755 USA. [Bair, Edward H.; Dozier, Jeff] Univ Calif Santa Barbara, Earth Res Inst, Santa Barbara, CA 93106 USA. [Simenhois, Ron] SE Alaska Avalanche Ctr, Juneau, AK USA. [Birkeland, Karl] US Forest Serv, Natl Avalanche Ctr, Bozeman, MT USA. RP Bair, EH (reprint author), USA, Cold Reg Res & Engn Lab, Corps Engineers, 72 Lyme Rd, Hanover, NH 03755 USA. EM nbair@eri.ucsb.edu RI Dozier, Jeff/B-7364-2009 OI Dozier, Jeff/0000-0001-8542-431X FU Oak Ridge Institute for Scientific Education; NSF [EAR-0537327/EAR-1015057] FX The work was supported by the Oak Ridge Institute for Scientific Education and NSF Grants EAR-0537327/EAR-1015057. We thank Joachim Heierli for his assistance in applying the anticrack model and an anonymous reviewer for his or her contribution to our displacement error analysis. NR 43 TC 7 Z9 7 U1 0 U2 7 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0165-232X EI 1872-7441 J9 COLD REG SCI TECHNOL JI Cold Reg. Sci. Tech. PD AUG PY 2012 VL 79-80 BP 20 EP 28 DI 10.1016/j.coldregions.2012.02.007 PG 9 WC Engineering, Environmental; Engineering, Civil; Geosciences, Multidisciplinary SC Engineering; Geology GA 957XV UT WOS:000305201300002 ER PT J AU Ratchford, JB Crawford, BA Wolfenstine, J Allen, JL Lundgren, CA AF Ratchford, J. B. Crawford, B. A. Wolfenstine, J. Allen, J. L. Lundgren, C. A. TI Young's modulus of polycrystalline Li12Si7 using nanoindentation testing SO JOURNAL OF POWER SOURCES LA English DT Article DE Lithium; Silicon; Li12Si7; Young's modulus ID LITHIUM-ION BATTERIES; ELASTIC-MODULUS; SILICON; ANODES AB Young's modulus for Li12Si7 was determined from nanoindentation testing. Young's modulus for Li12Si7 was 52.0 +/- 8.2 GPa. This value is in excellent agreement with estimated values of Young's modulus calculated from predicted values of bulk modulus using density functional theory. Published by Elsevier B.V. C1 [Ratchford, J. B.; Wolfenstine, J.; Allen, J. L.; Lundgren, C. A.] USA, Res Lab, Adelphi Lab Ctr, Adelphi, MD 20783 USA. [Crawford, B. A.] Nanomechanics Inc, Analyt Serv Lab, Oak Ridge, TN 37830 USA. RP Lundgren, CA (reprint author), USA, Res Lab, Adelphi Lab Ctr, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM cynthia.a.lundgren2.civ@mail.mil FU Army Research Laboratory; National Research Council Research Associateship Award at the United States Army Research Laboratory FX The authors are grateful to the Army Research Laboratory for financial support. This research was performed while JBR held a National Research Council Research Associateship Award at the United States Army Research Laboratory. NR 18 TC 10 Z9 11 U1 1 U2 30 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0378-7753 J9 J POWER SOURCES JI J. Power Sources PD AUG 1 PY 2012 VL 211 BP 1 EP 3 DI 10.1016/j.jpowsour.2012.02.027 PG 3 WC Chemistry, Physical; Electrochemistry; Energy & Fuels; Materials Science, Multidisciplinary SC Chemistry; Electrochemistry; Energy & Fuels; Materials Science GA 960CF UT WOS:000305364900001 ER PT J AU Zhang, SS Tran, DT AF Zhang, Sheng S. Tran, Dat T. TI A proof-of-concept lithium/sulfur liquid battery with exceptionally high capacity density SO JOURNAL OF POWER SOURCES LA English DT Article DE Lithium/sulfur battery; Sulfur cathode; Polysulfide; Li anode; Cycle life ID SULFUR BATTERIES; ELECTROCHEMICAL PERFORMANCE; GEL ELECTROLYTE; CYCLE PROPERTY; CATHODE; IMPROVEMENT; COMPOSITES AB In this communication, we disclose a proof-of-concept lithium/sulfur liquid battery that has exceptionally high capacity density. In such a battery, the cathode consists of a highly porous carbon cloth (CC) as the cathode current collector and a porous sulfur paper as the source of active material. In the first discharge, sulfur is reduced on the CC surface into high order lithium polysulfide (PS), which dissolves into liquid electrolyte and serves as the catholyte of the so-called "Li/S liquid battery". By adopting a LiNO3-contained electrolyte to protect Li anode, the Li/S liquid cell is shown to cycle reversibly between 1.7 V and 2.8 V with an initial capacity of 778 mAh g(-1) S. corresponding to a capacity density of 10.1 mAh cm(-2) CC, which could be the highest capacity density among the rechargeable Li/S batteries reported ever. This work reveals that the high capacity density Li/S batteries can be made through a "Li/S liquid cell" by employing a highly porous carbon electrode to accommodate the insoluble sulfur reduction products (Li2S2/Li2S) with appropriate protection of the Li anode. Published by Elsevier B.V. C1 [Zhang, Sheng S.; Tran, Dat T.] USA, Res Lab, Electrochem Branch, RDRL SED C, Adelphi, MD 20783 USA. RP Zhang, SS (reprint author), USA, Res Lab, Electrochem Branch, RDRL SED C, Adelphi, MD 20783 USA. EM shengshui.zhang.civ@mail.mil RI Zhang, Sheng/A-4456-2012 OI Zhang, Sheng/0000-0003-4435-4110 NR 32 TC 62 Z9 63 U1 15 U2 174 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0378-7753 J9 J POWER SOURCES JI J. Power Sources PD AUG 1 PY 2012 VL 211 BP 169 EP 172 DI 10.1016/j.jpowsour.2012.04.006 PG 4 WC Chemistry, Physical; Electrochemistry; Energy & Fuels; Materials Science, Multidisciplinary SC Chemistry; Electrochemistry; Energy & Fuels; Materials Science GA 960CF UT WOS:000305364900026 ER PT J AU Boyd, RW Reynolds, PJ AF Boyd, Robert W. Reynolds, Peter J. TI Introduction to the special issue on quantum imaging SO QUANTUM INFORMATION PROCESSING LA English DT Editorial Material C1 [Boyd, Robert W.] Univ Rochester, Inst Opt, Rochester, NY 14627 USA. [Boyd, Robert W.] Univ Rochester, Dept Phys & Astron, Rochester, NY 14627 USA. [Boyd, Robert W.] Univ Ottawa, Dept Phys, Ottawa, ON K1N 6N5, Canada. [Boyd, Robert W.] Univ Ottawa, Sch Elect Engn & Comp Sci, Ottawa, ON K1N 6N5, Canada. [Reynolds, Peter J.] USA, Res Off, Div Phys, Res Triangle Pk, NC 27709 USA. [Reynolds, Peter J.] USA, Res Off, Phys Sci Directorate, Res Triangle Pk, NC 27709 USA. RP Boyd, RW (reprint author), Univ Rochester, Inst Opt, Rochester, NY 14627 USA. EM boydrw@mac.com NR 0 TC 1 Z9 1 U1 0 U2 8 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1570-0755 J9 QUANTUM INF PROCESS JI Quantum Inf. Process. PD AUG PY 2012 VL 11 IS 4 SI SI BP 887 EP 889 DI 10.1007/s11128-012-0401-z PG 3 WC Physics, Multidisciplinary; Physics, Mathematical SC Physics GA 962GL UT WOS:000305530200001 ER PT J AU Brennan, LM Widder, MW Lee, LEJ van der Schalie, WH AF Brennan, Linda M. Widder, Mark W. Lee, Lucy E. J. van der Schalie, William H. TI Long-term storage and impedance-based water toxicity testing capabilities of fluidic biochips seeded with RTgill-W1 cells SO TOXICOLOGY IN VITRO LA English DT Article DE Biosensor; Impedance; Rainbow trout gill epithelial cells; Toxic chemicals; Biochip; Water toxicity sensor ID RAINBOW-TROUT GILL; FISH CELLS; LINE; CYTOTOXICITY; BIOSENSORS; EFFLUENT; ABILITY; OSCILLATIONS; SENSITIVITY; TETRAHYMENA AB Rainbow trout gill epithelial cells (RTgill-W1) are used in a cell-based biosensor that can respond within one hour to toxic chemicals that have the potential to contaminate drinking water supplies. RTgill-W1 cells seeded on enclosed fluidic biochips and monitored using electric cell-substrate impedance sensing (ECIS) technology responded to 18 out of the 18 toxic chemicals tested within one hour of exposure. Nine of these chemical responses were within established concentration ranges specified by the U.S. Army for comparison of toxicity sensors for field application. The RTgill-W1 cells remain viable on the biochips at ambient carbon dioxide levels at 6 degrees C for 78 weeks without media changes. RTgill-W1 biochips stored in this manner were challenged with 9.4 mu M sodium pentachlorophenate (PCP), a benchmark toxicant, and impedance responses were significant (p < 0.001) for all storage times tested. This poikilothermic cell line has toxicant sensitivity comparable to a mammalian cell line (bovine lung microvessel endothelial cells (BLMVECs)) that was tested on fluidic biochips with the same chemicals. In order to remain viable, the BLMVEC biochips required media replenishments 3 times per week while being maintained at 37 degrees C. The ability of RTgill-W1 biochips to maintain monolayer integrity without media replenishments for 78 weeks, combined with their chemical sensitivity and rapid response time, make them excellent candidates for use in low cost, maintenance-free field-portable biosensors. Published by Elsevier Ltd. C1 [Brennan, Linda M.; Widder, Mark W.; van der Schalie, William H.] USA, Ctr Environm Hlth Res, Ft Detrick, MD USA. [Lee, Lucy E. J.] Wilfrid Laurier Univ, Dept Biol, Waterloo, ON N2L 3C5, Canada. RP Brennan, LM (reprint author), USA, Ctr Environm Hlth Res, Ft Detrick, MD USA. EM linda.brennan@us.army.mil; mark.widder@us.army.mil; llee@wlu.ca; william.vanderSchalie@us.army.mil RI Lee, Lucy/B-8849-2016 OI Lee, Lucy/0000-0003-1796-0588 FU US Army Medical Research and Materiel Command; Small Business Innovation Research program [W81XWH-04-C-0043]; Small Business Technology Transfer program [W81XWH-04-C-0140]; Natural Sciences and Engineering Research Council of Canada (NSERC); Cumulative Environmental Management Association (CEMA) FX We thank William Dennis and Alan Rosencrance of USACEHR for chemistry sample preparation and analysis. The authors would also like to thank Agave BioSystems and Nanohmics, Inc. for their expertise on the design and construction of the ECIS test units, Applied Biophysics for fabricating the electronic ECIS layers of the fluidic biochips and for assembling them, and Dr. Steve J. Schwager of Cornell University for writing the statistical program for the analysis of data. This work was supported by the US Army Medical Research and Materiel Command and by the Small Business Innovation Research and Small Business Technology Transfer programs, Contracts W81XWH-04-C-0043 and W81XWH-04-C-0140, respectively. Opinions, interpretations, conclusions, and recommendations are those of the authors and are not necessarily endorsed by the U.S. Army. Citations of commercial organizations or trade names in this report do not constitute an official Department of the Army endorsement or approval of the products or services of these organizations. Dr. Lucy Lee thanks the Natural Sciences and Engineering Research Council of Canada (NSERC) for continuous funding of her research program and the Cumulative Environmental Management Association (CEMA) for funding support. NR 47 TC 18 Z9 18 U1 1 U2 10 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0887-2333 J9 TOXICOL IN VITRO JI Toxicol. Vitro PD AUG PY 2012 VL 26 IS 5 BP 736 EP 745 DI 10.1016/j.tiv.2012.03.010 PG 10 WC Toxicology SC Toxicology GA 964EC UT WOS:000305675500013 PM 22469871 ER PT J AU Cho, YH Wolfenstine, J Rangasamy, E Kim, H Choe, H Sakamoto, J AF Cho, Yong-Hun Wolfenstine, Jeff Rangasamy, Ezhiylmurugan Kim, Hyunjoong Choe, Heeman Sakamoto, Jeff TI Mechanical properties of the solid Li-ion conducting electrolyte: Li0.33La0.57TiO3 SO JOURNAL OF MATERIALS SCIENCE LA English DT Article ID CRACK DEFLECTION PROCESSES; GRAIN-SIZE; FRACTURE-TOUGHNESS; ELASTIC-MODULUS; INDENTATION TECHNIQUES; POROSITY; HARDNESS; LI3XLA2/3-XTIO3; BETA''-ALUMINA; LI7LA3ZR2O12 AB Li0.33La0.57TiO3 (LLTO) is a potential Li-ion conducting membrane for use in aqueous Li-air batteries. To be in this configuration its mechanical properties must be determined. Dense LLTO was prepared using a solid-state (SS) or sol-gel (SG) procedure and was hot-pressed to yield a high relative density material (> 95 %). Young's modulus, hardness, and fracture toughness of the LLTO-SS and sol-gel LLTO-SG materials was determined and compared to other solid Li-ion conducting electrolytes. The Young's modulus for LLTO-SG and LLTO-SS was 186 +/- A 4 and 200 +/- A 3 GPa, respectively. The Vickers hardness of LLTO-SG and LLTO-SS was 9.7 +/- A 0.7 and 9.2 +/- A 0.2 GPa, respectively. The fracture toughness, K (IC), of both LLTO-SG and LLTO-SS was similar to 1 MPa m(1/2); the fracture toughness of LLTO-SG was slightly higher than that of LLTO-SS. Both LLTO-SG and LLTO-SS have a Young's modulus and hardness greater than the other possible solid Li-ion conducting membranes; Li7La3Zr2O12 and Li1+x+y Al (x) Ti2-x Si (y) P3-y O-12. Based on modulus and hardness hot-pressed LLTO exhibits sufficient mechanical integrity to be used as a solid Li-ion conducting membrane in aqueous Li-air batteries but, its fracture toughness needs to be improved without degrading its ionic conductivity. C1 [Rangasamy, Ezhiylmurugan; Kim, Hyunjoong; Sakamoto, Jeff] Michigan State Univ, Dept Chem Engn & Mat Sci, E Lansing, MI 48824 USA. [Cho, Yong-Hun; Choe, Heeman] Kookmin Univ, Sch Adv Mat Engn, Seoul 136702, South Korea. [Wolfenstine, Jeff] USA, Res Lab, RDRL SED C, Adelphi, MD 20783 USA. RP Sakamoto, J (reprint author), Michigan State Univ, Dept Chem Engn & Mat Sci, 2527 Michigan State Univ, E Lansing, MI 48824 USA. EM jsakamot@msu.edu RI Rangasamy, Ezhiylmurugan/K-8340-2013; Choe, Heeman/J-4053-2013 OI Choe, Heeman/0000-0002-5908-577X FU Priority Research Centers through the National Research Foundation of Korea (NRF); Ministry of Education, Science, and Technology [2009-0093814]; National Research Foundation of Korea [KRF-2008-313-D00012]; U.S. Army Research Laboratory (ARL); Army Research Office (ARO) FX This study was supported by the Priority Research Centers Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science, and Technology (2009-0093814) and the National Research Foundation of Korea Grant (KRF-2008-313-D00012). JW would like to acknowledge the support of the U.S. Army Research Laboratory (ARL). Authors JS, ER and HK would like to acknowledge support from the Army Research Office (ARO). NR 50 TC 15 Z9 15 U1 5 U2 75 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0022-2461 J9 J MATER SCI JI J. Mater. Sci. PD AUG PY 2012 VL 47 IS 16 BP 5970 EP 5977 DI 10.1007/s10853-012-6500-5 PG 8 WC Materials Science, Multidisciplinary SC Materials Science GA 949YZ UT WOS:000304616000008 ER PT J AU Yen, CF AF Yen, Chian-Fong TI A ballistic material model for continuous-fiber reinforced composites SO INTERNATIONAL JOURNAL OF IMPACT ENGINEERING LA English DT Article DE Ballistic impact; Composite materials; Damage mechanics; Material model; Rate effect ID LAMINATED COMPOSITES; STRAIN-RATE; IMPACT; DAMAGE; FAILURE AB A ply-level material constitutive model for plain-weave composite laminates has been developed to enable computational analyses of progressive damage/failure in the laminates under high velocity ballistic impact conditions. In this model, failure-initiation criteria and damage evolution laws are introduced to account for the major fiber-failure modes (tensile, compressive, punch shear and crush loading). In addition, two matrices related failure modes (in-plane shear and through the thickness delamination) are also accounted for. These types of fiber and matrix failure modes are commonly observed during a ballistic event. The composite-material model has been implemented within LS-DYNA as a user-defined material subroutine and used successfully to predict the damage and ballistic behavior of composite laminates subjected to various ballistic impact conditions. It is hoped that the availability of this material model will help facilitate the development of composite structures with enhanced ballistic survivability. Published by Elsevier Ltd. C1 USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Yen, CF (reprint author), USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. EM chianfong.yen@us.army.mil FU U.S. Army Research Laboratory [DAAD17-00-C-0059] FX Initiation of this work was supported by the U.S. Army Research Laboratory under Contract No. DAAD17-00-C-0059 when the author was working at Materials Sciences Corporation. NR 39 TC 17 Z9 18 U1 3 U2 9 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0734-743X J9 INT J IMPACT ENG JI Int. J. Impact Eng. PD AUG PY 2012 VL 46 BP 11 EP 22 DI 10.1016/j.ijimpeng.2011.12.007 PG 12 WC Engineering, Mechanical; Mechanics SC Engineering; Mechanics GA 930YD UT WOS:000303179800002 ER PT J AU Wilmsmeyer, AR Uzarski, J Barrie, PJ Morris, JR AF Wilmsmeyer, Amanda R. Uzarski, Joshua Barrie, Patrick J. Morris, John R. TI Interactions and Binding Energies of Dimethyl Methylphosphonate and Dimethyl Chlorophosphate with Amorphous Silica SO LANGMUIR LA English DT Article ID TEMPERATURE-PROGRAMMED DESORPTION; CHEMICAL WARFARE AGENTS; POROUS CATALYSTS; HYDROGEN-BOND; ADSORPTION; SURFACE; SENSORS; SIO2 AB The fundamental interactions of dimethyl methylphosphonate (DMMP) and dimethyl chlorophosphate (DMCP) on amorphous silica nanoparticles have been investigated with transmission infrared spectroscopy and temperature-programmed desorption (TPD). DMMP and DMCP both adsorb molecularly to silica through the formation of hydrogen bonds between isolated silanols and the phosphoryl oxygen of the adsorbate. The magnitude of the shift of the v(OH) mode upon simulant adsorption is correlated to the adsorption strength. The activation energies for desorption for a single DMMP or DMCP molecule from amorphous silica varied with coverage. In the limit of zero coverage, after the effects of defects were excluded, the activation energies were 54.5 +/- 0.3 and 48.4 +/- 1.0 kJ/mol for DMMP and DMCP, respectively. C1 [Wilmsmeyer, Amanda R.; Morris, John R.] Virginia Tech, Dept Chem, Blacksburg, VA 24061 USA. [Uzarski, Joshua] USA, Natick Soldier Res Dev & Engn Ctr, Natick, MA 01760 USA. [Barrie, Patrick J.] Univ Cambridge, Dept Chem Engn & Biotechnol, Cambridge CB2 3RA, England. RP Morris, JR (reprint author), Virginia Tech, Dept Chem, Blacksburg, VA 24061 USA. FU Army Research Office [W911NF-09-1-0150]; Defense Threat Reduction Agency [W911NF-06-1-0111] FX The support of the Army Research Office, W911NF-09-1-0150, and the Defense Threat Reduction Agency, W911NF-06-1-0111, is gratefully acknowledged. We thank Professor Diego Troya for many helpful discussions. The authors also thank Z. Dohnalek for a helpful discussion regarding the use of the inversion analysis. NR 23 TC 11 Z9 11 U1 1 U2 51 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0743-7463 J9 LANGMUIR JI Langmuir PD JUL 31 PY 2012 VL 28 IS 30 BP 10962 EP 10967 DI 10.1021/la301938f PG 6 WC Chemistry, Multidisciplinary; Chemistry, Physical; Materials Science, Multidisciplinary SC Chemistry; Materials Science GA 011XP UT WOS:000309199900002 PM 22780431 ER PT J AU Golden, JW Josleyn, M Mucker, EM Hung, CF Loudon, PT Wu, TC Hooper, JW AF Golden, Joseph W. Josleyn, Matthew Mucker, Eric M. Hung, Chien-Fu Loudon, Peter T. Wu, T. C. Hooper, Jay W. TI Side-by-Side Comparison of Gene-Based Smallpox Vaccine with MVA in Nonhuman Primates SO PLOS ONE LA English DT Article ID HEAT-LABILE ENTEROTOXIN; ESCHERICHIA-COLI; PROTECTIVE IMMUNITY; VIRUS CHALLENGE; POXVIRUS INFECTION; LETHAL MONKEYPOX; DNA VACCINATION; NEUTRALIZING ANTIBODIES; MUCOSAL ADJUVANTICITY; ANKARA ACAM3000 AB Orthopoxviruses remain a threat as biological weapons and zoonoses. The licensed live-virus vaccine is associated with serious health risks, making its general usage unacceptable. Attenuated vaccines are being developed as alternatives, the most advanced of which is modified-vaccinia virus Ankara (MVA). We previously developed a gene-based vaccine, termed 4pox, which targets four orthopoxvirus antigens, A33, B5, A27 and L1. This vaccine protects mice and non-human primates from lethal orthopoxvirus disease. Here, we investigated the capacity of the molecular adjuvants GM-CSF and Escherichia coli heat-labile enterotoxin (LT) to enhance the efficacy of the 4pox gene-based vaccine. Both adjuvants significantly increased protective antibody responses in mice. We directly compared the 4pox plus LT vaccine against MVA in a monkeypox virus (MPXV) nonhuman primate (NHP) challenge model. NHPs were vaccinated twice with MVA by intramuscular injection or the 4pox/LT vaccine delivered using a disposable gene gun device. As a positive control, one NHP was vaccinated with ACAM2000. NHPs vaccinated with each vaccine developed anti-orthopoxvirus antibody responses, including those against the 4pox antigens. After MPXV intravenous challenge, all control NHPs developed severe disease, while the ACAM2000 vaccinated animal was well protected. All NHPs vaccinated with MVA were protected from lethality, but three of five developed severe disease and all animals shed virus. All five NHPs vaccinated with 4pox/LT survived and only one developed severe disease. None of the 4pox/LT-vaccinated animals shed virus. Our findings show, for the first time, that a subunit orthopoxvirus vaccine delivered by the same schedule can provide a degree of protection at least as high as that of MVA. C1 [Golden, Joseph W.; Josleyn, Matthew; Hooper, Jay W.] USA, Med Res Inst Infect Dis, Dept Mol Virol, Div Virol, Ft Detrick, MD 21702 USA. [Mucker, Eric M.] USA, Med Res Inst Infect Dis, Dept Viral Therapeut, Div Virol, Ft Detrick, MD 21702 USA. [Hung, Chien-Fu; Wu, T. C.] Johns Hopkins Med Inst, Dept Pathol, Baltimore, MD 21205 USA. [Loudon, Peter T.] Pfizer Ltd, Sandwich Labs, Sandwich CT13 9NJ, Kent, England. RP Golden, JW (reprint author), USA, Med Res Inst Infect Dis, Dept Mol Virol, Div Virol, Ft Detrick, MD 21702 USA. EM jay.hooper@amedd.army.mil OI Hooper, Jay/0000-0002-4475-0415 FU National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Health and Human Services [IAA Y1-AI-9426-02]; NIAID [UO1 AI070346-01] FX This project was funded in part with Federal funds from the National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Health and Human Services under IAA Y1-AI-9426-02, Appendix A120 B.19 and NIAID UO1 AI070346-01. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 73 TC 5 Z9 5 U1 0 U2 5 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD JUL 31 PY 2012 VL 7 IS 7 AR e42353 DI 10.1371/journal.pone.0042353 PG 13 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 982LS UT WOS:000307045600093 PM 22860117 ER PT J AU Katz, A Sankaran, V AF Katz, Aaron Sankaran, Venkateswaran TI High aspect ratio grid effects on the accuracy of Navier-Stokes solutions on unstructured meshes SO COMPUTERS & FLUIDS LA English DT Article; Proceedings Paper CT 6th International Conference on Computational Fluid Dynamics (ICCFD) CY JUL 12-16, 2010 CL St Petersburg, RUSSIA SP Aerosp Res & Dev, European Off, Natl Aeronaut & Space Adm DE Computational fluid dynamics; Mesh quality; Method of manufactured solutions; Unstructured grids; High aspect-ratio grids ID VERIFICATION; CODE AB The method of manufactured solutions is used to evaluate the stability and accuracy of several unstructured discretization schemes in the presence of high-aspect ratio grids. Both inviscid and viscous discretizations are studied by systematically varying parameters such as the aspect ratio, mesh stretching, curvature, skewness, and non-planar faces. For the inviscid terms, gradient reconstruction based on cell least squares and nodal Green-Gauss are considered. In particular, high curvature grids are shown to lead to instabilities with both classes of schemes and a new Green-Gauss scheme based on nodal projection is developed that retains stability and formal second-order accuracy under all conditions. A further advantage of the nodal Green-Gauss schemes is that the nodal values can be used in the viscous discretization as well. All the viscous schemes tested here are demonstrated to preserve second-order accuracy. Finally, for three-dimensional meshes, triangulation of non-planar faces is found to be necessary to preserve second-order accuracy. (c) 2012 Elsevier Ltd. All rights reserved. C1 [Katz, Aaron; Sankaran, Venkateswaran] USA, Aeroflightdynam Directorate AMRDEC, Moffett Field, CA 94035 USA. RP Katz, A (reprint author), NASA, Ames Res Ctr, M-S 215-1, Moffett Field, CA 94035 USA. EM akatz@merlin.arc.nasa.gov RI Katz, Aaron/I-8244-2015 OI Katz, Aaron/0000-0003-2739-9384 NR 23 TC 5 Z9 6 U1 0 U2 3 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0045-7930 J9 COMPUT FLUIDS JI Comput. Fluids PD JUL 30 PY 2012 VL 65 SI SI BP 66 EP 79 DI 10.1016/j.compfluid.2012.02.012 PG 14 WC Computer Science, Interdisciplinary Applications; Mechanics SC Computer Science; Mechanics GA 994IM UT WOS:000307924100008 ER PT J AU Jiang, RZ Tran, DT McClure, JP Chu, D AF Jiang, Rongzhong Tran, Dat T. McClure, Joshua P. Chu, Deryn TI Increasing the electrochemically available active sites for heat-treated hemin catalysts supported on carbon black SO ELECTROCHIMICA ACTA LA English DT Article DE BET surface area; Heat-treatment; Hemin; ORR catalysts; Ultrasound; Fuel cell ID CHEMICALLY-MODIFIED ELECTRODES; ELECTROCATALYTIC REDUCTION; COBALT; DIOXYGEN; OXYGEN; POLYANILINE; PORPHYRINS; IRON AB A nano-sized non-noble metal catalyst containing hemin supported on carbon black was synthesized for the oxygen reduction reaction (ORR). The hemin supported on carbon black was heat-treated (HT), and subjected to additional ultrasound treatments to increase the BET surface area and available active sites for the ORR. The HT hemin supported on carbon black was characterized with thermogravimetric analysis (TGA), elemental analysis, transmission electron microscopy (TEM), and BET surface area analysis. The catalytic activity of the synthesized electrocatalysts was analyzed with cyclic voltammetry (CV), rotating disk electrode (RDE), and rotating ring disk electrode (RRDE). The effect of BET surface area on formal potential, anodic and cathodic peak currents, limiting currents, half wave potentials, and kinetic rate constant for ORR were studied. We found an apparent correlation between catalytic activity and BET surface area for this particular catalyst. Increasing BET surface area, the ORR catalytic activity increases significantly. Our research on HT hemin indicates that the catalytic activity for ORR significantly improves by reducing the particle size and increasing the surface area. Published by Elsevier Ltd. C1 [Jiang, Rongzhong; Tran, Dat T.; Chu, Deryn] USA, Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA. [McClure, Joshua P.] N Carolina State Univ, Dept Chem & Biomol Engn, Raleigh, NC 27695 USA. RP Jiang, RZ (reprint author), USA, Res Lab, Sensors & Electron Devices Directorate, 2800 Powder Mill Road, Adelphi, MD 20783 USA. EM Rongzhong.jiang.civ@mail.mil FU U.S. Department of the Army; U.S. Army Materiel Command FX The authors wish to thank Dr. Li-Chung Lai at University of Maryland for assisting TEM analysis, and the U.S. Department of the Army and U.S. Army Materiel Command for financial support. NR 14 TC 13 Z9 14 U1 2 U2 42 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0013-4686 J9 ELECTROCHIM ACTA JI Electrochim. Acta PD JUL 30 PY 2012 VL 75 BP 185 EP 190 DI 10.1016/j.electacta.2012.04.098 PG 6 WC Electrochemistry SC Electrochemistry GA 980HL UT WOS:000306884100025 ER PT J AU Kissner, TL Ruthel, G Alam, S Mann, E Ajami, D Rebek, M Larkin, E Fernandez, S Ulrich, RG Ping, S Waugh, DS Rebek, J Saikh, KU AF Kissner, Teri L. Ruthel, Gordon Alam, Shahabuddin Mann, Enrique Ajami, Dariush Rebek, Mitra Larkin, Eileen Fernandez, Stefan Ulrich, Robert G. Ping, Sun Waugh, David S. Rebek, Julius, Jr. Saikh, Kamal U. TI Therapeutic Inhibition of Pro-Inflammatory Signaling and Toxicity to Staphylococcal Enterotoxin B by a Synthetic Dimeric BB-Loop Mimetic of MyD88 SO PLOS ONE LA English DT Article ID MHC CLASS-II; INNATE IMMUNE-RESPONSES; CRYSTAL-STRUCTURE; HUMAN-DISEASE; MOLECULES; CYTOKINE; SHOCK; ENDOTOXIN; DOMAIN; MICE AB Staphylococcal enterotoxin B (SEB) exposure triggers an exaggerated pro-inflammatory cytokine response that often leads to toxic shock syndrome (TSS) associated with organ failure and death. MyD88 mediates pro-inflammatory cytokine signaling induced by SEB exposure and MyD88(-/-) mice are resistant to SEB intoxication, suggesting that MyD88 may be a potential target for therapeutic intervention. We targeted the BB loop region of the Toll/IL-1 receptor (TIR) domain of MyD88 to develop small-molecule therapeutics. Here, we report that a synthetic compound (EM-163), mimic to dimeric form of BB-loop of MyD88 attenuated tumor necrosis factor (TNF)-alpha, interferon (IFN)-gamma, interleukin (IL)-1 beta, IL-2 and IL-6 production in human primary cells, whether administered pre- or post-SEB exposure. Results from a direct binding assay, and from MyD88 co-transfection/co-immunoprecipitation experiments, suggest that EM-163 inhibits TIR-TIR domain interaction. Additional results indicate that EM-163 prevents MyD88 from mediating downstream signaling. In an NF-kBdriven reporter assay of lipopolysaccharide-stimulated MyD88 signaling, EM-163 demonstrated a dose-dependent inhibition of reporter activity as well as TNF-alpha and IL-1 beta production. Importantly, administration of EM-163 pre- or post exposure to a lethal dose of SEB abrogated pro-inflammatory cytokine responses and protected mice from toxic shock-induced death. Taken together, our results suggest that EM-163 exhibits a potential for therapeutic use against SEB intoxication. C1 [Kissner, Teri L.; Ruthel, Gordon; Alam, Shahabuddin; Larkin, Eileen; Fernandez, Stefan; Ulrich, Robert G.; Saikh, Kamal U.] USA, Med Res Inst Infect Dis, Dept Immunol, Frederick, MD USA. [Mann, Enrique; Ajami, Dariush; Rebek, Mitra] Scripps Res Inst, Dept Chem, Skaggs Inst Chem Biol, La Jolla, CA 92037 USA. [Ping, Sun; Waugh, David S.; Rebek, Julius, Jr.] NCI, Macromol Crystallog Lab, Frederick, MD 21701 USA. RP Kissner, TL (reprint author), USA, Med Res Inst Infect Dis, Dept Immunol, Frederick, MD USA. EM kamal.saikh@amedd.army.mil RI Ajami, Dariush/A-1312-2014; Mann, Enrique /K-6594-2014 OI Mann, Enrique /0000-0002-2050-4295 FU Defense Threat Reduction Agency (DTRA) [CBM.THRTOX.03.10.RD.006] FX This work was supported by the Defense Threat Reduction Agency (DTRA; WWW.jpras.us) grant CBM.THRTOX.03.10.RD.006 to Kamal U. Saikh. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 34 TC 9 Z9 9 U1 0 U2 9 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD JUL 27 PY 2012 VL 7 IS 7 AR e40773 DI 10.1371/journal.pone.0040773 PG 12 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 981ER UT WOS:000306950200030 PM 22848400 ER PT J AU Lentine, KL Vijayan, A Xiao, HL Schnitzler, MA Davis, CL Garg, AX Axelrod, D Abbott, KC Brennan, DC AF Lentine, Krista L. Vijayan, Anitha Xiao, Huiling Schnitzler, Mark A. Davis, Connie L. Garg, Amit X. Axelrod, David Abbott, Kevin C. Brennan, Daniel C. TI Cancer Diagnoses After Living Kidney Donation: Linking US Registry Data and Administrative Claims SO TRANSPLANTATION LA English DT Article DE Administrative claims; Cancer; Kidney transplantation; Living donors; Registries ID UNITED-STATES; TRANSPLANT CENTERS; DONORS; GUIDELINES; RECIPIENTS; MELANOMA; OUTCOMES; RISK AB Background. Mortality records identify cancer as the leading cause of death among living kidney donors, but information on the burden of cancer outside death records is limited in this population. Methods. We examined a database wherein U.S. Organ Procurement and Transplantation Network identifiers for 4,650 living kidney donors in 1987 to 2007 were linked to administrative data of a U.S. private health insurer (2000-2007 claims) to identify postdonation cancer diagnoses. Skin cancer and non-skin cancer diagnoses were ascertained from International Classification of Diseases, Ninth Revision, Clinical Modification diagnosis codes on billing claims. Donors were also matched one-to-one with general insurance beneficiaries by sex and age when benefits began. Diagnosis rates within observation windows were compared as rate ratios. Results. The median time from donation to the end of plan insurance enrollment was 7.7 years, with a median observation period of 2.1 years. Skin cancer rates were similar among prior living donors in the observation period and nondonor controls (rate ratio, 0.91; 95% confidence interval [CI], 0.59-1.40). In contrast, the rate of total non-skin cancers was significantly less common among donors than among controls (rate ratio, 0.74; 95% CI, 0.55-0.99), although reduced relative risk was limited to donors captured earlier in relation to donation. Several cases of cancer diagnosis (uterine, melanoma, "other'') were identified within the first year after donation. Prostate cancer diagnosis was significantly more common among living donors compared with controls (rate ratio, 3.80; 95% CI, 1.42-10.2). Conclusions. Continued study of cancer after kidney donation is warranted to ensure that evaluation, selection, and long-term follow-up support overall good health of the donor. C1 [Lentine, Krista L.; Xiao, Huiling; Schnitzler, Mark A.] St Louis Univ, Ctr Outcomes Res, Sch Med, St Louis, MO 63104 USA. [Lentine, Krista L.] St Louis Univ, Div Nephrol, Sch Med, St Louis, MO 63104 USA. [Vijayan, Anitha; Brennan, Daniel C.] Washington Univ, Sch Med, Div Nephrol, St Louis, MO USA. [Davis, Connie L.] Univ Washington, Sch Med, Div Nephrol, Seattle, WA USA. [Garg, Amit X.] Univ Western Ontario, Div Nephrol, London, ON, Canada. [Axelrod, David] Dartmouth Hitchcock Med Ctr, Dept Surg, Hanover, NH USA. [Abbott, Kevin C.] Walter Reed Army Med Ctr, Serv Nephrol, Washington, DC 20307 USA. RP Lentine, KL (reprint author), St Louis Univ, Ctr Outcomes Res, Sch Med, Salus Ctr 4th Floor,3545 Lafayette Ave, St Louis, MO 63104 USA. EM lentinek@slu.edu OI Abbott, Kevin/0000-0003-2111-7112 FU National Institute of Diabetes Digestive and Kidney Diseases (NIDDK) [K08DK073036, P30DK079333] FX K.L.L. was supported in part by Grant K08DK073036 from the National Institute of Diabetes Digestive and Kidney Diseases (NIDDK). M. A. S. and D. C. B. were supported in part by Grant P30DK079333 from the NIDDK. NR 25 TC 8 Z9 8 U1 0 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0041-1337 J9 TRANSPLANTATION JI Transplantation PD JUL 27 PY 2012 VL 94 IS 2 BP 139 EP 144 DI 10.1097/TP.0b013e318254757d PG 6 WC Immunology; Surgery; Transplantation SC Immunology; Surgery; Transplantation GA 977SN UT WOS:000306685000011 PM 22825543 ER PT J AU Lowe, MR Wu, W Peterson, MS Brown-Peterson, NJ Slack, WT Schofield, PJ AF Lowe, Michael R. Wu, Wei Peterson, Mark S. Brown-Peterson, Nancy J. Slack, William T. Schofield, Pamela J. TI Survival, Growth and Reproduction of Non-Native Nile Tilapia II: Fundamental Niche Projections and Invasion Potential in the Northern Gulf of Mexico SO PLOS ONE LA English DT Article ID COASTAL MISSISSIPPI WATERSHEDS; SPECIES DISTRIBUTION MODELS; CLIMATE-CHANGE; OREOCHROMIS-NILOTICUS; BIOLOGICAL INVASIONS; LOGISTIC-REGRESSION; LAKE PONTCHARTRAIN; FISH; AQUACULTURE; ESTUARIES AB Understanding the fundamental niche of invasive species facilitates our ability to predict both dispersal patterns and invasion success and therefore provides the basis for better-informed conservation and management policies. Here we focus on Nile tilapia (Oreochromis niloticus Linnaeus, 1758), one of the most widely cultured fish worldwide and a species that has escaped local aquaculture facilities to become established in a coastal-draining river in Mississippi (northern Gulf of Mexico). Using empirical physiological data, logistic regression models were developed to predict the probabilities of Nile tilapia survival, growth, and reproduction at different combinations of temperature (14 and 30 degrees C) and salinity (0-60, by increments of 10). These predictive models were combined with kriged seasonal salinity data derived from multiple long-term data sets to project the species' fundamental niche in Mississippi coastal waters during normal salinity years (averaged across all years) and salinity patterns in extremely wet and dry years (which might emerge more frequently under scenarios of climate change). The derived fundamental niche projections showed that during the summer, Nile tilapia is capable of surviving throughout Mississippi's coastal waters but growth and reproduction were limited to river mouths (or upriver). Overwinter survival was also limited to river mouths. The areas where Nile tilapia could survive, grow, and reproduce increased during extremely wet years (2-368%) and decreased during extremely dry years (86-92%) in the summer with a similar pattern holding for overwinter survival. These results indicate that Nile tilapia is capable of 1) using saline waters to gain access to other watersheds throughout the region and 2) establishing populations in nearshore, low-salinity waters, particularly in the western portion of coastal Mississippi. C1 [Lowe, Michael R.; Wu, Wei; Peterson, Mark S.; Brown-Peterson, Nancy J.] Univ So Mississippi, Dept Coastal Sci, Ocean Springs, MS USA. [Slack, William T.] USA, Waterways Expt Stn, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. [Schofield, Pamela J.] US Geol Survey, SE Ecol Sci Ctr, Gainesville, FL USA. RP Lowe, MR (reprint author), Univ So Mississippi, Dept Coastal Sci, Ocean Springs, MS USA. EM michael.lowe@eagles.usm.edu FU United States Fish and Wildlife Service (Region 4); United States Geological Survey Invasive Species Program; departmental fellowship through the Department of Coastal Sciences at the University of Southern Mississippi FX None of the work in this manuscript was funded directly. Funding for previous aspects of this study were provided by the United States Fish and Wildlife Service (Region 4) and the United States Geological Survey Invasive Species Program. MRL was funded through a departmental fellowship through the Department of Coastal Sciences at the University of Southern Mississippi. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 88 TC 18 Z9 21 U1 5 U2 42 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD JUL 27 PY 2012 VL 7 IS 7 AR e41580 DI 10.1371/journal.pone.0041580 PG 10 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 981ER UT WOS:000306950200072 PM 22848533 ER PT J AU Blair, JRS Manne, F AF Blair, Jean R. S. Manne, Fredrik TI An efficient self-stabilizing distance-2 coloring algorithm SO THEORETICAL COMPUTER SCIENCE LA English DT Article ID PLANAR GRAPHS; NETWORKS AB The problem of assigning frequencies to processes so as to avoid interference can in many instances be modeled as a graph coloring problem on the processor graph where no two processes that are sufficiently close are assigned the same color. One version of this problem requires that processes within distance two of each other have different colors. This is known as the distance-2 coloring problem. We present a self-stabilizing algorithm for this problem that uses O(log Delta) memory on each node and that stabilizes in O(Delta(2)m) time steps for any scheduler (synchronous or asynchronous) using at most Delta(2) + 1 colors, where Delta is the maximum degree in the graph and m is the number of edges in the graph. The analysis holds true for both the sequential and distributed adversarial daemon models. This should be compared with the previous best self-stabilizing algorithm for this problem which stabilizes in O(nm) moves under the sequential adversarial daemon and in O(n(3)m) time steps for the distributed adversarial daemon and which uses O(delta(i) log Delta) memory on each node i, where n is the number of nodes in the graph and delta(i) is the degree of node i. (c) 2012 Elsevier B.V. All rights reserved. C1 [Blair, Jean R. S.] US Mil Acad, Off Dean, West Point, NY 10996 USA. [Manne, Fredrik] Univ Bergen, Dept Informat, N-5020 Bergen, Norway. RP Blair, JRS (reprint author), US Mil Acad, Off Dean, Taylor Hall, West Point, NY 10996 USA. EM Jean.Blair@usma.edu; fredrikm@ii.uib.no NR 21 TC 5 Z9 5 U1 0 U2 3 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0304-3975 J9 THEOR COMPUT SCI JI Theor. Comput. Sci. PD JUL 27 PY 2012 VL 444 BP 28 EP 39 DI 10.1016/j.tcs.2012.01.034 PG 12 WC Computer Science, Theory & Methods SC Computer Science GA 969FS UT WOS:000306041700004 ER PT J AU Terry, K Sinitski, EH Dingwell, JB Wilken, JM AF Terry, Kevin Sinitski, Emily H. Dingwell, Jonathan B. Wilken, Jason M. TI Amplitude effects of medio-lateral mechanical and visual perturbations on gait SO JOURNAL OF BIOMECHANICS LA English DT Article DE Balance; Perturbation; Gait; Strategies; Movement ID WALKING; VARIABILITY; ENVIRONMENT; BALANCE AB Falls during walking are a major contributor to accidental deaths and injuries that can result in debilitating hospitalization costs, lost productivity, and diminished quality of life. To reduce these losses, we must develop a more profound understanding of the characteristic responses to perturbations similar to those encountered in daily life. This study addresses this issue by building on our earlier studies that examined mechanical and visual perturbations in the same environment by applying the same continuous pseudo-random perturbations at multiple (3 mechanical, 5 visual) amplitudes. Walking variability during mechanical perturbations increased significantly with amplitude for all subjects and differences as measured by variabilities of step width, COM position, and COM velocity. These parameters were the only ones sensitive to the presence of visual perturbations, but none of them changed significantly with perturbation amplitude. Additionally, visual perturbation effects were far less consistent across participants, with several who were essentially unaffected by visual perturbations at any level. The homogeneity of the mechanical perturbation effects demonstrates that human responses to mechanical perturbations are similar because they are driven by kinetics that require similar corrections that must be made in order to maintain balance. Conversely, responses to visual perturbations are driven by the perceived need to make corrections and this perception is not accurate enough to produce amplitude-related corrections, even for a single participant, nor is this perception consistent across individuals. This latter finding is likely to be relevant to future visual perturbation studies and the diagnosis and rehabilitation of gait and balance disorders. (C) 2012 Elsevier Ltd. All rights reserved. C1 [Terry, Kevin; Sinitski, Emily H.; Wilken, Jason M.] Brooke Army Med Ctr, Ctr Intrepid, Dept Orthoped & Rehabil, Ft Sam Houston, TX 78234 USA. [Terry, Kevin; Dingwell, Jonathan B.] Univ Texas Austin, Dept Kinesiol & Hlth Educ, Austin, TX 78712 USA. RP Wilken, JM (reprint author), Brooke Army Med Ctr, Ctr Intrepid, Dept Orthoped & Rehabil, Ft Sam Houston, TX 78234 USA. EM Jason.Wilken@amedd.army.mil RI Terry, Kevin/L-2760-2013; OI Terry, Kevin/0000-0001-7708-1740; Wilken, Jason/0000-0002-5556-7667; Dingwell, Jonathan/0000-0001-6990-4153 FU NIH [R01-HD059844] FX This research was supported by NIH Grant R01-HD059844. The views expressed herein are those of the authors and do not reflect the official policy or position of Brooke Army Medical Center, the US Army Medical Department, the US Army Office of the Surgeon General, the Department of the Army, Department of Defense or the US Government, NR 16 TC 7 Z9 8 U1 1 U2 8 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0021-9290 J9 J BIOMECH JI J. Biomech. PD JUL 26 PY 2012 VL 45 IS 11 BP 1979 EP 1986 DI 10.1016/j.jbiomech.2012.05.006 PG 8 WC Biophysics; Engineering, Biomedical SC Biophysics; Engineering GA 986CL UT WOS:000307318300019 PM 22648147 ER PT J AU Shukla, MK Hill, F AF Shukla, Manoj K. Hill, Frances TI Computational Elucidation of Mechanisms of Alkaline Hydrolysis of Nitrocellulose: Dimer and Trimer Models with Comparison to the Corresponding Monomer SO JOURNAL OF PHYSICAL CHEMISTRY A LA English DT Article ID THERMAL-DECOMPOSITION; CELLULOSE NITRATE; KINETICS; DEGRADATION AB Density functional theory (DFT) investigation has been undertaken to explore alkaline hydrolysis mechanisms for nitrocellulose in the gas phase and in bulk water solution by considering the dimer and trimer forms of 2,3,6-trinitro-beta-D-glucopyranose in the C-4(1) chair conformation and by comparing the computed results with the monomer. Ground and transition state geometries were optimized using the B3LYP functional and the 6-311G(d,p) basis set both in the gas phase. and in:the bulk water solution. The nature of respective potential : energy surfaces was ascertained through harmonic vibrational frequency analysis.' Intrinsic reaction Coordinate calculations were performed to ensure that computed transition state connects to the respective reactants and products. Single point energy calculations were also performed using the recently developed M06-2X functional,and the cc-pVTZ basis set using the B3LYP/6-311G(d,p) optimized geometries. Effect of the bulk water solution was modeled Using the polarizable continuum model (PCM) approach. It has been suggested that the dimeric form of 2,3,6-trinitro-beta-D-glucopyranose can be considered as the smallest model to study the nitrocellulose system regarding the alkaline hydrolysis reaction It was predicted that the peeling off reaction will start after the denitration of various sites, which will follow a C3 -> C6 -> C2 denitration route. Further, it was determined that the peeling off reaction will be more preferred than the ring cleavage through the ring CO bond. C1 [Shukla, Manoj K.; Hill, Frances] USA, Engn Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA. RP Shukla, MK (reprint author), USA, Engn Res & Dev Ctr, Environm Lab, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM Manoj.K.Shukla@usace.army.mil NR 25 TC 1 Z9 1 U1 1 U2 21 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1089-5639 J9 J PHYS CHEM A JI J. Phys. Chem. A PD JUL 26 PY 2012 VL 116 IS 29 BP 7746 EP 7755 DI 10.1021/jp3042878 PG 10 WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical SC Chemistry; Physics GA 978EU UT WOS:000306724200018 PM 22742429 ER PT J AU Lau, TM Gwin, JT McDowell, KG Ferris, DP AF Lau, Troy M. Gwin, Joseph T. McDowell, Kaleb G. Ferris, Daniel P. TI Weighted phase lag index stability as an artifact resistant measure to detect cognitive EEG activity during locomotion SO JOURNAL OF NEUROENGINEERING AND REHABILITATION LA English DT Article DE Electroencephalography (EEG); Walking; Movement artifact; Artifact removal; Connectivity; Phase lag ID BRAIN; NETWORK; SYNCHRONIZATION; CONNECTIVITY; REMOVAL; WALKING; P300; P3A AB Background: High-density electroencephalography (EEG) with active electrodes allows for monitoring of electrocortical dynamics during human walking but movement artifacts have the potential to dominate the signal. One potential method for recovering cognitive brain dynamics in the presence of gait-related artifact is the Weighted Phase Lag Index. Methods: We tested the ability of Weighted Phase Lag Index to recover event-related potentials during locomotion. Weighted Phase Lag Index is a functional connectivity measure that quantified how consistently 90 degrees (or 270 degrees) phase 'lagging' one EEG signal was compared to another. 248-channel EEG was recorded as eight subjects performed a visual oddball discrimination and response task during standing and walking (0.8 or 1.2 m/s) on a treadmill. Results: Applying Weighted Phase Lag Index across channels we were able to recover a p300-like cognitive response during walking. This response was similar to the classic amplitude-based p300 we also recovered during standing. We also showed that the Weighted Phase Lag Index detects more complex and variable activity patterns than traditional voltage-amplitude measures. This variability makes it challenging to compare brain activity over time and across subjects. In contrast, a statistical metric of the index's variability, calculated over a moving time window, provided a more generalized measure of behavior. Weighted Phase Lag Index Stability returned a peak change of 1.8% + -0.5% from baseline for the walking case and 3.9% + -1.3% for the standing case. Conclusions: These findings suggest that both Weighted Phase Lag Index and Weighted Phase Lag Index Stability have potential for the on-line analysis of cognitive dynamics within EEG during human movement. The latter may be more useful from extracting general principles of neural behavior across subjects and conditions. C1 [Lau, Troy M.; Gwin, Joseph T.; Ferris, Daniel P.] Univ Michigan, Human Neuromech Lab, Sch Kinesiol, Ann Arbor, MI 48109 USA. [Lau, Troy M.; McDowell, Kaleb G.] USA, Res Lab, Human Res & Engn Directorate, Translat Neuroscience Branch, Aberdeen, MD 21005 USA. RP Lau, TM (reprint author), Univ Michigan, Human Neuromech Lab, Sch Kinesiol, Ann Arbor, MI 48109 USA. EM troylau@umich.edu RI Ferris, Daniel/A-9624-2008 OI Ferris, Daniel/0000-0001-6373-6021 NR 32 TC 13 Z9 13 U1 2 U2 16 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1743-0003 J9 J NEUROENG REHABIL JI J. NeuroEng. Rehabil. PD JUL 24 PY 2012 VL 9 AR 47 DI 10.1186/1743-0003-9-47 PG 9 WC Engineering, Biomedical; Neurosciences; Rehabilitation SC Engineering; Neurosciences & Neurology; Rehabilitation GA 033OF UT WOS:000310806600001 PM 22828128 ER PT J AU Cohen, EB Moore, FR Fischer, RA AF Cohen, Emily B. Moore, Frank R. Fischer, Richard A. TI Experimental Evidence for the Interplay of Exogenous and Endogenous Factors on the Movement Ecology of a Migrating Songbird SO PLOS ONE LA English DT Article ID CATBIRDS DUMETELLA-CAROLINENSIS; PASSERINE MIGRANTS; HABITAT SELECTION; REPRODUCTIVE-PERFORMANCE; INSECTIVOROUS BIRDS; FOOD AVAILABILITY; STOPOVER ECOLOGY; SPATIAL-BEHAVIOR; FAT; COMPETITION AB Movement patterns during songbird migration remain poorly understood despite their expected fitness consequences in terms of survival, energetic condition and timing of migration that will carry over to subsequent phases of the annual cycle. We took an experimental approach to test hypotheses regarding the influence of habitat, energetic condition, time of season and sex on the hour-by-hour, local movement decisions of a songbird during spring stopover. To simulate arrival of nocturnal migrants at unfamiliar stopover sites, we translocated and continuously tracked migratory red-eyed vireos (Vireo olivaceus) throughout spring stopover with and without energetic reserves that were released in two replicates of three forested habitat types. Migrants moved the most upon release, during which time they selected habitat characterized by greater food abundance and higher foraging attack rates. Presumably under pressure to replenish fuel stores necessary to continue migration in a timely fashion, migrants released in poorer energetic condition moved faster and further than migrants in better condition and the same pattern was true for migrants released late in spring relative to those released earlier. However, a migrant's energetic condition had less influence on their behavior when they were in poor quality habitat. Movement did not differ between sexes. Our study illustrates the importance of quickly finding suitable habitat at each stopover site, especially for energetically constrained migrants later in the season. If an initial period prior to foraging were necessary at each stop along a migrant's journey, non-foraging periods would cumulatively result in a significant energetic and time cost to migration. However, we suggest behavior during stopover is not solely a function of underlying resource distributions but is a complex response to a combination of endogenous and exogenous factors. C1 [Cohen, Emily B.; Moore, Frank R.] Univ So Mississippi, Dept Biol Sci, Hattiesburg, MS 39406 USA. [Fischer, Richard A.] United States Army Engn Res & Dev Ctr, Environm Lab, Vicksburg, MS USA. RP Cohen, EB (reprint author), Smithsonian Conservat Biol Inst, Natl Zool Pk, Migratory Bird Ctr, Washington, DC USA. EM cohene@si.edu FU The University of Southern Mississippi; Department of Defense Strategic Environmental Research and Development Program (SERDP) [SI-1469] FX Funding for this project was provided by The University of Southern Mississippi and the Department of Defense Strategic Environmental Research and Development Program (SERDP Project SI-1469). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 58 TC 16 Z9 16 U1 1 U2 44 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD JUL 23 PY 2012 VL 7 IS 7 AR e41818 DI 10.1371/journal.pone.0041818 PG 11 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 977TM UT WOS:000306687700155 PM 22844528 ER PT J AU Ranallo, RT Fonseka, S Boren, TL Bedford, LA Kaminski, RW Thakkar, S Venkatesan, MM AF Ranallo, Ryan T. Fonseka, Suramya Boren, Tara L. Bedford, Lisa A. Kaminski, Robert W. Thakkar, Sejal Venkatesan, Malabi M. TI Two live attenuated Shigella flexneri 2a strains WRSf2G12 and WRSf2G15: A new combination of gene deletions for 2nd generation live attenuated vaccine candidates SO VACCINE LA English DT Article DE S. flexneri 2a vaccine; Live Shigella vaccine; WRSf2G12 and WRSf2G15 ID ENTEROPATHOGENIC ESCHERICHIA-COLI; PIG KERATOCONJUNCTIVITIS MODEL; LARGE VIRULENCE PLASMID; GUINEA-PIG; MONOCLONAL-ANTIBODIES; INTESTINAL EPITHELIUM; PROTECTIVE EFFICACY; DIVERSE SEROTYPES; IMMUNE-RESPONSE; SUICIDE VECTOR AB oShigella infections are a major cause of inflammatory diarrhea and dysentery worldwide. First-generation virG-based live attenuated Shigella strains have been successfully tested in phase I and II clinical trials and are a leading approach for Shigella vaccine development. Additional gene deletions in senA, senB and msbB2 have been engineered into second-generation virG-based Shigella flexneri 2a strains producing WRSf2G12 and WRSf2G15. Both strains harbor a unique combination of gene deletions designed to increase the safety of live Shigella vaccines. WRSf2G12 and WRSf2G15 are genetically stable and highly attenuated in both cell culture and animal models of infection. Ocular immunization of guinea pigs with either strain induces robust systemic and mucosal immune responses that protect against homologous challenge with wildtype Shigella. The data support further evaluation of the second-generation strains in a phase I clinical trial. (C) 2012 Elsevier Ltd. All rights reserved. C1 [Ranallo, Ryan T.; Fonseka, Suramya; Boren, Tara L.; Bedford, Lisa A.; Kaminski, Robert W.; Thakkar, Sejal; Venkatesan, Malabi M.] Walter Reed Army Inst Res, Div Bacterial & Rickettsial Dis, Silver Spring, MD 20814 USA. RP Venkatesan, MM (reprint author), Walter Reed Army Inst Res, Div Bacterial & Rickettsial Dis, 503 Robert Grant Ave, Silver Spring, MD 20814 USA. EM malabi.venkatesan@us.army.mil NR 60 TC 11 Z9 11 U1 0 U2 3 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X J9 VACCINE JI Vaccine PD JUL 20 PY 2012 VL 30 IS 34 BP 5159 EP 5171 DI 10.1016/j.vaccine.2012.05.003 PG 13 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 981PP UT WOS:000306982000014 PM 22658966 ER PT J AU Sanghavi, BJ Hirsch, G Karna, SP Srivastava, AK AF Sanghavi, Bankim J. Hirsch, Gary Karna, Shashi P. Srivastava, Ashwini K. TI Potentiometric stripping analysis of methyl and ethyl parathion employing carbon nanoparticles and halloysite nanoclay modified carbon paste electrode SO ANALYTICA CHIMICA ACTA LA English DT Article DE Methyl parathion; Ethyl parathion; Carbon nanoparticles; Halloysite nanoclay; Potentiometric stripping analysis ID CHROMATOGRAPHY MASS-SPECTROMETRY; ORGANOPHOSPHATE PESTICIDE SENSOR; CHEMICALLY-MODIFIED ELECTRODES; SOLID-PHASE EXTRACTION; LIQUID-CHROMATOGRAPHY; BIOMIMETIC SENSOR; ACID; ACETAMINOPHEN; VOLTAMMETRY; DEGRADATION AB Carbon nanoparticles (CNPs) and halloysite nanoclay (HNC) modified carbon paste electrode (HNC-CNP-CPE) was developed for the determination of methyl parathion (MP) and ethyl parathion (EP). The electrochemical behavior of these molecules was investigated employing cyclic voltammetry (CV), chronocoulometry (CC), electrochemical impedance spectroscopy (EIS) and potentiometric stripping analysis (PSA). After optimization of analytical conditions employing this electrode at pH 5.0 in acetate buffer (0.1 M), the peak currents were found to vary linearly with its concentration in the range of 1.55 x 10(-9) to 3.67 x 10(-6) M and 1.21 x 10(-9) to 4.92 x 10(-6) M for MP and EP, respectively. The detection limits (S/N = 3) of 4.70 x 10(-10) M and 3.67 x 10(-10) M were obtained for MP and EP, respectively, using PSA. The prepared modified electrode showed several advantages such as simple preparation method, high sensitivity, very low detection limits and excellent reproducibility. The proposed method was employed for the determination of MP and EP in fruits, vegetables, water and soil samples. (C) 2012 Elsevier B.V. All rights reserved. C1 [Sanghavi, Bankim J.; Srivastava, Ashwini K.] Univ Mumbai, Dept Chem, Bombay 400098, Maharashtra, India. [Hirsch, Gary; Karna, Shashi P.] USA, Res Lab, Weap & Mat Res Directorate, ATTN RDRL WM, Aberdeen Proving Ground, MD 21005 USA. RP Srivastava, AK (reprint author), Univ Mumbai, Dept Chem, Bombay 400098, Maharashtra, India. EM aksrivastava@chem.mu.ac.in FU Council of Scientific and Industrial Research, New Delhi, India [09/019(0092)2K11/EMR-I] FX One of the authors (B.J.S.) is thankful to the Council of Scientific and Industrial Research, New Delhi, India for providing financial assistance in the form of Senior Research Fellowship [09/019(0092)2K11/EMR-I]. NR 47 TC 66 Z9 66 U1 7 U2 63 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0003-2670 J9 ANAL CHIM ACTA JI Anal. Chim. Acta PD JUL 20 PY 2012 VL 735 BP 37 EP 45 DI 10.1016/j.aca.2012.05.029 PG 9 WC Chemistry, Analytical SC Chemistry GA 970RQ UT WOS:000306150400005 PM 22713915 ER PT J AU West, D West, BJ AF West, Damien West, Bruce J. TI ON ALLOMETRY RELATIONS SO INTERNATIONAL JOURNAL OF MODERN PHYSICS B LA English DT Review DE Allometry; fractals; physiology; scaling; statistical analysis; ontogenetic growth ID UNIVERSAL SCALING LAWS; ECOLOGICAL COMMUNITY DESCRIPTION; MAMMALIAN RESPIRATORY SYSTEM; BODY-SIZE; BRONCHIAL TREE; POPULATION-DENSITY; LOGARITHMIC TRANSFORMATION; ONTOGENIC GROWTH; METABOLIC-RATE; GENERAL-MODEL AB There are a substantial number of empirical relations that began with the identification of a pattern in data; were shown to have a terse power-law description; were interpreted using existing theory; reached the level of "law" and given a name; only to be subsequently fade away when it proved impossible to connect the "law" with a larger body of theory and/or data. Various forms of allometry relations (ARs) have followed this path. The ARs in biology are nearly two hundred years old and those in ecology, geophysics, physiology and other areas of investigation are not that much younger. In general if X is a measure of the size of a complex host network and Y is a property of a complex subnetwork embedded within the host network a theoretical AR exists between the two when Y = aX(b). We emphasize that the reductionistic models of AR interpret X and Y as dynamic variables, albeit the ARs themselves are explicitly time independent even though in some cases the parameter values change over time. On the other hand, the phenomenological models of AR are based on the statistical analysis of data and interpret X and Y as averages to yield the empirical AR: < Y > = a < X >(b). Modern explanations of AR begin with the application of fractal geometry and fractal statistics to scaling phenomena. The detailed application of fractal geometry to the explanation of theoretical ARs in living networks is slightly more than a decade old and although well received it has not been universally accepted. An alternate perspective is given by the empirical AR that is derived using linear regression analysis of fluctuating data sets. We emphasize that the theoretical and empirical ARs are not the same and review theories "explaining" AR from both the reductionist and statistical fractal perspectives. The probability calculus is used to systematically incorporate both views into a single modeling strategy. We conclude that the empirical AR is entailed by the scaling behavior of the probability density, which is derived using the probability calculus. C1 [West, Damien] Rensselaer Polytech Inst, Dept Phys, Troy, NY 12180 USA. [West, Bruce J.] USA, Res Off, Informat Sci Directorate, Res Triangle Pk, NC 27709 USA. RP West, D (reprint author), Rensselaer Polytech Inst, Dept Phys, Troy, NY 12180 USA. RI West, Damien/F-8616-2012 OI West, Damien/0000-0002-4970-3968 NR 264 TC 9 Z9 9 U1 5 U2 43 PU WORLD SCIENTIFIC PUBL CO PTE LTD PI SINGAPORE PA 5 TOH TUCK LINK, SINGAPORE 596224, SINGAPORE SN 0217-9792 EI 1793-6578 J9 INT J MOD PHYS B JI Int. J. Mod. Phys. B PD JUL 20 PY 2012 VL 26 IS 18 AR 1230010 DI 10.1142/S0217979212300101 PG 57 WC Physics, Applied; Physics, Condensed Matter; Physics, Mathematical SC Physics GA 973BO UT WOS:000306326800002 ER PT J AU Gaidamakova, EK Myles, IA McDaniel, DP Fowler, CJ Valdez, PA Naik, S Gayen, M Gupta, P Sharma, A Glass, PJ Maheshwari, RK Datta, SK Daly, MJ AF Gaidamakova, Elena K. Myles, Ian A. McDaniel, Dennis P. Fowler, Cedar J. Valdez, Patricia A. Naik, Shruti Gayen, Manoshi Gupta, Paridhi Sharma, Anuj Glass, Pamela J. Maheshwari, Radha K. Datta, Sandip K. Daly, Michael J. TI Preserving Immunogenicity of Lethally Irradiated Viral and Bacterial Vaccine Epitopes Using a Radio-Protective Mn2+-Peptide Complex from Deinococcus SO CELL HOST & MICROBE LA English DT Article ID VENEZUELAN EQUINE ENCEPHALITIS; STAPHYLOCOCCUS-AUREUS; RADIATION-RESISTANCE; IONIZING-RADIATION; ESCHERICHIA-COLI; GAMMA-RADIATION; PROTEIN DAMAGE; RADIODURANS; IMMUNITY; DNA AB Although pathogen inactivation by gamma-radiation is an attractive approach for whole-organism vaccine development, radiation doses required to ensure sterility also destroy immunogenic protein epitopes needed to mount protective immune responses. We demonstrate the use of a reconstituted manganous peptide complex from the radiation-resistant bacterium Deinococcus radiodurans to protect protein epitopes from radiation-induced damage and uncouple it from genome damage and organism killing. The Mn2+ complex preserved antigenic structures in aqueous preparations of bacteriophage lambda, Venezuelan equine encephalitis virus, and Staphylococcus aureus during supralethal irradiation (25-40 kGy). An irradiated vaccine elicited both antibody and Th17 responses, and induced B and T cell-dependent protection against methicillin-resistant S. aureus (MRSA) in mice. Structural integrity of viruses and bacteria are shown to be preserved at radiation doses far above those which abolish infectivity. This approach could expedite vaccine production for emerging and established pathogens for which no protective vaccines exist. C1 [Myles, Ian A.; Fowler, Cedar J.; Valdez, Patricia A.; Datta, Sandip K.] NIAID, Bacterial Pathogenesis Unit, Lab Clin Infect Dis, NIH, Bethesda, MD 20892 USA. [Naik, Shruti] NIAID, Mucosal Immunol Sect, Parasit Dis Lab, NIH, Bethesda, MD 20892 USA. [Gaidamakova, Elena K.; Gayen, Manoshi; Gupta, Paridhi; Sharma, Anuj; Maheshwari, Radha K.; Daly, Michael J.] Uniformed Serv Univ Hlth Sci, Dept Pathol, Sch Med, Bethesda, MD 20814 USA. [McDaniel, Dennis P.] Uniformed Serv Univ Hlth Sci, Dept Microbiol & Immunol, Sch Med, Bethesda, MD 20814 USA. [Naik, Shruti] Univ Penn, Immunol Grad Grp, Philadelphia, PA 19104 USA. [Gayen, Manoshi; Gupta, Paridhi] Birla Inst Technol & Sci, Biol Sci Dept, Pilani 333031, Rajasthan, India. [Glass, Pamela J.] USA, Virol Div, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. RP Datta, SK (reprint author), NIAID, Bacterial Pathogenesis Unit, Lab Clin Infect Dis, NIH, Bethesda, MD 20892 USA. EM dattas@niaid.nih.gov; michael.daly@usuhs.edu OI Sharma, Anuj/0000-0001-6906-190X; Datta, Sandip/0000-0003-0243-7815 FU Air Force Office of Scientific Research; Defense Threat Reduction Agency; Intramural Research Program of the NIAID FX This work was supported by the Air Force Office of Scientific Research (E.K.G., D.P.M., and M.J.D.), the Defense Threat Reduction Agency (M.G., P.G., A.S., P.J.G., and R.K.M.), and the Intramural Research Program of the NIAID (I.A.M., C.J.F., P.A.V., S.N., and S.K.D.). We thank Rodney L. Levine (NHLBI, NIH) for authenticating the decapeptide by HPLC-MS, and Vera Y. Matrosova (USUHS) for technical assistance in quantifying lambda phage pfu. We thank A. Mullbacher (The Australian National University), B. Stern (Harvard University), and F. DeLeo (NIAID) for critical reading of the manuscript. NR 37 TC 15 Z9 15 U1 4 U2 12 PU CELL PRESS PI CAMBRIDGE PA 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA SN 1931-3128 J9 CELL HOST MICROBE JI Cell Host Microbe PD JUL 19 PY 2012 VL 12 IS 1 BP 117 EP 124 DI 10.1016/j.chom.2012.05.011 PG 8 WC Microbiology; Parasitology; Virology SC Microbiology; Parasitology; Virology GA 981CA UT WOS:000306941900013 PM 22817993 ER PT J AU Yizengaw, E Zesta, E Moldwin, MB Damtie, B Mebrahtu, A Valladares, CE Pfaff, RF AF Yizengaw, E. Zesta, E. Moldwin, M. B. Damtie, B. Mebrahtu, A. Valladares, C. E. Pfaff, R. F. TI Longitudinal differences of ionospheric vertical density distribution and equatorial electrodynamics SO JOURNAL OF GEOPHYSICAL RESEARCH-SPACE PHYSICS LA English DT Article ID TOTAL ELECTRON-CONTENT; TOMOGRAPHY; STORM; LATITUDES; SPACE AB Accurate estimation of global vertical distribution of ionospheric and plasmaspheric density as a function of local time, season, and magnetic activity is required to improve the operation of space-based navigation and communication systems. The vertical density distribution, especially at low and equatorial latitudes, is governed by the equatorial electrodynamics that produces a vertical driving force. The vertical structure of the equatorial density distribution can be observed by using tomographic reconstruction techniques on ground-based global positioning system (GPS) total electron content (TEC). Similarly, the vertical drift, which is one of the driving mechanisms that govern equatorial electrodynamics and strongly affect the structure and dynamics of the ionosphere in the low/midlatitude region, can be estimated using ground magnetometer observations. We present tomographically reconstructed density distribution and the corresponding vertical drifts at two different longitudes: the East African and west South American sectors. Chains of GPS stations in the east African and west South American longitudinal sectors, covering the equatorial anomaly region of meridian similar to 37 degrees E and 290 degrees E, respectively, are used to reconstruct the vertical density distribution. Similarly, magnetometer sites of African Meridian B-field Education and Research (AMBER) and INTERMAGNET for the east African sector and South American Meridional B-field Array (SAMBA) and Low Latitude Ionospheric Sensor Network (LISN) are used to estimate the vertical drift velocity at two distinct longitudes. The comparison between the reconstructed and Jicamarca Incoherent Scatter Radar (ISR) measured density profiles shows excellent agreement, demonstrating the usefulness of tomographic reconstruction technique in providing the vertical density distribution at different longitudes. Similarly, the comparison between magnetometer estimated vertical drift and other independent drift observation, such as from VEFI onboard Communication/Navigation Outage Forecasting System (C/NOFS) satellite and JULIA radar, is equally promising. The observations at different longitudes suggest that the vertical drift velocities and the vertical density distribution have significant longitudinal differences; especially the equatorial anomaly peaks expand to higher latitudes more in American sector than the African sector, indicating that the vertical drift in the American sector is stronger than the African sector. C1 [Yizengaw, E.; Valladares, C. E.] Boston Coll, Inst Sci Res, Chestnut Hill, MA 02467 USA. [Zesta, E.] USA, Res Lab, AFRL VSBXP, Hanscom AFB, Bedford, MA USA. [Moldwin, M. B.] Univ Michigan, Dept Atmospher Ocean & Space Sci, Ann Arbor, MI 48109 USA. [Damtie, B.] Bahir Dar Univ, Washera Geospace & Radar Sci Lab, Bahir Dar, Ethiopia. [Mebrahtu, A.] Mekelle Univ, Dept Phys, Mekelle, Ethiopia. [Pfaff, R. F.] NASA, Goddard Space Flight Ctr, Greenbelt, MD 20771 USA. RP Yizengaw, E (reprint author), Boston Coll, Inst Sci Res, 140 Commonwealth Ave, Chestnut Hill, MA 02467 USA. EM endawoke.kassie@bc.edu RI Pfaff, Robert/F-5703-2012; Moldwin, Mark/F-8785-2011; Yizengaw, Endawoke/I-3471-2015 OI Pfaff, Robert/0000-0002-4881-9715; Moldwin, Mark/0000-0003-0954-1770; Yizengaw, Endawoke/0000-0001-5772-3355 FU NASA IHY program [NNX07AM22G]; NASA LWS program [NNX11AP02G, NNX10AQ53G]; NASA Geospace Science program [NNX09AR84G]; AFOSR YIP grant [FA9550-10-1-0096] FX This work was supported by NASA IHY (NNX07AM22G), LWS (NNX11AP02G and NNX10AQ53G) and Geospace Science programs (NNX09AR84G) and AFOSR YIP grant (FA9550-10-1-0096). The authors are indebted to the IGS and UNAVCO GPS, Jicamarca radar, and INTERMAGNET magnetometer teams for the data resources they made available to the public. NR 30 TC 10 Z9 10 U1 0 U2 2 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA SN 2169-9380 EI 2169-9402 J9 J GEOPHYS RES-SPACE JI J. Geophys. Res-Space Phys. PD JUL 19 PY 2012 VL 117 AR A07312 DI 10.1029/2011JA017454 PG 10 WC Astronomy & Astrophysics SC Astronomy & Astrophysics GA 977YN UT WOS:000306701700002 ER PT J AU Kasper, MR Lescano, AG Lucas, C Gilles, D Biese, BJ Stolovitz, G Reaves, EJ AF Kasper, Matthew R. Lescano, Andres G. Lucas, Carmen Gilles, Duncan Biese, Brian J. Stolovitz, Gary Reaves, Erik J. TI Diarrhea Outbreak during US Military Training in El Salvador SO PLOS ONE LA English DT Article ID ENTEROTOXIGENIC ESCHERICHIA-COLI; OPERATIONS IRAQI FREEDOM; TRAVELERS DIARRHEA; SOUTH-AMERICA; ENDURING FREEDOM; MULTIPLEX PCR; WEST-AFRICA; PERSONNEL; EPIDEMIOLOGY; EGYPT AB Infectious diarrhea remains a major risk to deployed military units worldwide in addition to their impact on travelers and populations living in the developing world. This report describes an outbreak of diarrheal illness in the U.S. military's 130th Maneuver Enhancement Brigade deployed in San Vicente, El Salvador during a training and humanitarian assistance mission. An outbreak investigation team from U.S. Naval Medical Research Unit - Six conducted an epidemiologic survey and environmental assessment, patient interviews, and collected stool samples for analysis in an at risk population of 287 personnel from May 31st to June 3rd, 2011. Personnel (n = 241) completed an epidemiological survey (87% response rate) and 67 (27%) reported diarrhea and/or vomiting during the past two weeks. The median duration of illness was reported to be 3 days (IQR 2-4 days) and abdominal pain was reported among 30 (49%) individuals. Presentation to the medical aid station was sought by (62%) individuals and 9 (15%) had to stop or significantly reduce work for at least one day. Microscopy and PCR analysis of 14 stool samples collected from previously symptomatic patients, Shigella (7), Cryptosporidium (5), and Cyclospora (4) were the most prevalent pathogens detected. Consumption of food from on-base local vendors (RR = 4.01, 95% CI = 1.53-10.5, p-value <0.001) and arriving on base within the past two weeks (RR = 2.79, 95% confidence [CI] = 1.35-5.76, p-value = 0.001) were associated with increased risk of developing diarrheal disease. The risk of infectious diarrhea is great among reserve military personnel during two week training exercises. The consumption of local food, prepared without proper monitoring, is a risk factor for deployed personnel developing diarrheal illness. Additional information is needed to better understand disease risks to personnel conducting humanitarian assistance activities in the Latin America Region. C1 [Kasper, Matthew R.; Lescano, Andres G.; Lucas, Carmen; Reaves, Erik J.] USN, Med Res Unit 6, Lima, Peru. [Gilles, Duncan] Madigan Healthcare Syst, Tacoma, WA USA. [Biese, Brian J.; Stolovitz, Gary] US Army Reserve, Combat Support Hosp 452, Milwaukee, WI USA. [Lescano, Andres G.] Univ Peruana Cayetano Heredia, Lima, Peru. RP Kasper, MR (reprint author), USN, Med Res Unit 6, Lima, Peru. EM Matthew.kasper@med.navy.mil RI Valle, Ruben/A-7512-2013; Lescano, Andres/B-8479-2008 OI Lescano, Andres/0000-0001-9779-633X FU U.S. Department of Defense Global Emerging Infectious Systems (DoD-GEIS), a division of the Armed Forces Health Surveillance Center; National Institutes of Health/Fogarty International Center [2D43 TW0007393] FX This work was funded by the U.S. Department of Defense Global Emerging Infectious Systems (DoD-GEIS), a division of the Armed Forces Health Surveillance Center. The participation of Dr. Lescano in this activity was partially funded by the National Institutes of Health/Fogarty International Center training grant 2D43 TW0007393 "Peru Infectious Diseases Epidemiology Research Training Consortium". The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 30 TC 10 Z9 11 U1 0 U2 3 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD JUL 18 PY 2012 VL 7 IS 7 AR e40404 DI 10.1371/journal.pone.0040404 PG 8 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 975YY UT WOS:000306548900025 PM 22815747 ER PT J AU Chung, MK White, PS Lee, SJ Waters, ML Gagne, MR AF Chung, Mee-Kyung White, Peter S. Lee, Stephen J. Waters, Marcey L. Gagne, Michel R. TI Self-Assembled Multi-Component Catenanes: Structural Insights into an Adaptable Class of Molecular Receptors and [2]-Catenanes SO JOURNAL OF THE AMERICAN CHEMICAL SOCIETY LA English DT Article ID DYNAMIC COMBINATORIAL LIBRARIES; CH/PI INTERACTIONS; SUPRAMOLECULAR CHEMISTRY; BIOLOGICAL RECOGNITION; AROMATIC INTERACTIONS; PI INTERACTIONS; HYDROGEN-BONDS; PROTEINS; PEPTIDES; CONFORMATIONS AB Under acidic conditions (50 equiv of TFA), combinations of hydrazide A-B monomers self-assemble into octameric [2]-catenanes with high selectivity for [1(3)2](2), where 1 is a D-Pro-X (X = Aib, Ac(4)c, Ac(6)c, L-4-Cl-PhGly)-derived monomer and 2 is an L-Pro'-L-arylGly (Pro' = Pro, trans-F-Pro, trans-HO-Pro, aryl = naphthyl, phenyl)-derived monomer. Five different combinations of monomers were studied by X-ray crystallography. In each case, the unique aryl glycine unit is located in the core of the structure where the aryl ring templates a CHI-pi-CH sandwich. Analysis of metrical parameters indicates that this core region is highly conserved, while the more peripheral zones are flexible. H-1 NMR spectroscopy indicate that the solid-state structures are largely retained in solution, though several non-C-2-symmetric compounds have a net C-2-symmetry that indicates accessible dynamic processes. Catenane dynamic processes were additionally probed through H/D exchange, with the core being inflexible relative to the peripheral structure. Mass spectrometry was utilized to identify the constitutional isomerism in the minor asymmetric [1(5)2(3)] catenanes. C1 [Chung, Mee-Kyung; White, Peter S.; Waters, Marcey L.; Gagne, Michel R.] Univ N Carolina, Dept Chem, Chapel Hill, NC 27599 USA. [Lee, Stephen J.] USA, Res Off, Res Triangle Pk, NC 27709 USA. RP Waters, ML (reprint author), Univ N Carolina, Dept Chem, CB 3290, Chapel Hill, NC 27599 USA. EM mlwaters@unc.edu; mgagne@unc.edu FU Defense Threat Reduction Agency (DTRA) [HDTRA1-10-1-0030]; Army Research Office FX We thank the Defense Threat Reduction Agency (DTRA) for support (HDTRA1-10-1-0030). S.J.L. thanks the Army Research Office for support. We thank Dr. Marc ter Horst for helpful discussions of NMR spectroscopy techniques. NR 85 TC 20 Z9 20 U1 3 U2 39 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0002-7863 J9 J AM CHEM SOC JI J. Am. Chem. Soc. PD JUL 18 PY 2012 VL 134 IS 28 BP 11415 EP 11429 DI 10.1021/ja302345n PG 15 WC Chemistry, Multidisciplinary SC Chemistry GA 974SV UT WOS:000306457900031 PM 22686480 ER PT J AU Chung, MK Lee, SJ Waters, ML Gagne, MR AF Chung, Mee-Kyung Lee, Stephen J. Waters, Marcey L. Gagne, Michel R. TI Self-Assembled Multi-Component Catenanes: The Effect of Multivalency and Cooperativity on Structure and Stability SO JOURNAL OF THE AMERICAN CHEMICAL SOCIETY LA English DT Article ID SICKLE-CELL HEMOGLOBINS; BETA-HAIRPIN PEPTIDES; CH/PI HYDROGEN-BONDS; C-H/PI-INTERACTIONS; PI INTERACTIONS; THEORETICAL DETERMINATION; CHIRAL DISCRIMINATION; VANCOMYCIN RESISTANCE; CONSTRAINED PEPTIDES; INTERACTION ENERGIES AB Using dynamic combinatorial chemistry, mixtures of dipeptide monomers were combined to probe how the structural elements of a family of self-assembled [2]-catenanes affect their equilibrium stability versus competing non-catenated structures. Of particular interest were experiments to target the effects of CH-pi interactions, inter-ring hydrogen bonds, and beta-turn types on [2]-catenane energetics. The non-variant core of the [2]-catenane was shown only to adopt type II' and type VIII turns at the beta-2 and beta-4 positions, respectively. Monomers were designed to delineate how these factors contribute to [2]-catenane equilibrium speciation/stability. Dipeptide turn adaptation studies, including three-component dynamic self-assembly experiments, suggested that stability losses are localized to the mutated sites, and that the turn types for the core beta-2 and beta-4 positions, type II' and type VIII, respectively, cannot be modified. Mutagenesis studies on the core Aib residue involved in a seemingly key CH-pi-CH sandwich reported on how CH-pi interactions and inter-ring hydrogen bonds affect stability. The interacting methyl group of Aib could be replaced with a range of alkyl and aryl substituents with monotonic affects on stability, though polar heteroatoms were disproportionately destabilizing. The importance of a key crossring H-bond was also probed by examining an Aib for L-Pro variant. Inductiye affects and the effect of CH donor multiplicity on the core proline-pi interaction also demonstrated that electronegative substituents and the number of CH donors can enhance the effectiveness of a CH-pi interaction. These data were interpreted using a cooperative binding model wherein multiple non-covalent interactions create a web of interdependent interactions. In some cases, changes to a component of the web lead to compensating effects in the linked interactions, while in others, the perturbations create a cascade of destabilizing interactions that lead to disproportionate losses in stability. C1 [Chung, Mee-Kyung; Waters, Marcey L.; Gagne, Michel R.] Univ N Carolina, Dept Chem, Chapel Hill, NC 27599 USA. [Lee, Stephen J.] USA, Res Off, Res Triangle Pk, NC 27709 USA. RP Waters, ML (reprint author), Univ N Carolina, Dept Chem, CB 3290, Chapel Hill, NC 27599 USA. EM mlwaters@unc.edu; mgagne@unc.edu FU Defense Threat Reduction Agency (DTRA) [HDTRA1-10-1-0030]; Army Research Office FX We thank the Defense Threat Reduction Agency (DTRA) for support (HDTRA1-10-1-0030). S.J.L. thanks the Army Research Office for support. NR 94 TC 30 Z9 30 U1 4 U2 62 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0002-7863 J9 J AM CHEM SOC JI J. Am. Chem. Soc. PD JUL 18 PY 2012 VL 134 IS 28 BP 11430 EP 11443 DI 10.1021/ja302342q PG 14 WC Chemistry, Multidisciplinary SC Chemistry GA 974SV UT WOS:000306457900032 PM 22686511 ER PT J AU Warner, CM Gust, KA Stanley, JK Habib, T Wilbanks, MS Garcia-Reyero, N Perkins, EJ AF Warner, Christopher M. Gust, Kurt A. Stanley, Jacob K. Habib, Tanwir Wilbanks, Mitchell S. Garcia-Reyero, Natalia Perkins, Edward J. TI A Systems Toxicology Approach to Elucidate the Mechanisms Involved in RDX Species-Specific Sensitivity SO ENVIRONMENTAL SCIENCE & TECHNOLOGY LA English DT Article ID BOBWHITE COLINUS-VIRGINIANUS; MINNOW PIMEPHALES-PROMELAS; ADVERSE OUTCOME PATHWAYS; HEXAHYDRO-1,3,5-TRINITRO-1,3,5-TRIAZINE RDX; FATHEAD MINNOW; GENE-EXPRESSION; RISK-ASSESSMENT; FISH; ECOTOXICOLOGY; TOXICITY AB Interspecies uncertainty factors in ecological risk assessment provide conservative estimates of risk where limited or no toxicity data is available. We quantitatively examined the validity of interspecies uncertainty factors by comparing the responses of zebrafish (Danio rerio) and fathead minnow (Pimephales promelas) to the energetic compound 1,3,5-trinitroperhydro-1,3,5-triazine (RDX), a known neurotoxicant. Relative toxicity was measured through transcriptional, morphological, and behavioral end points in zebrafish and fathead minnow fry exposed for 96 h to RDX concentrations ranging from 0.9 to 27.7 mg/L. Spinal deformities and lethality occurred at 1.8 and 3.5 mg/L RDX respectively for fathead minnow and at 13.8 and 27.7 mg/L for zebrafish, indicating that zebrafish have an 8-fold greater tolerance for RDX than fathead minnow fry. The number and magnitude of differentially expressed transcripts increased with increasing RDX concentration for both species. Differentially expressed genes were enriched in functions related to neurological disease, oxidative stress, acute phase response, vitamin/mineral metabolism and skeletal/muscular disorders Decreased expression of collagen coding transcripts were associated with spinal deformity and likely involved in sensitivity to RDX. Our work provides a mechanistic explanation for species specific sensitivity to RDX where zebrafish responded at lower concentrations with greater numbers of functions related to RDX tolerance than fathead minnow. While the 10 fold interspecies uncertainty factor does provide a reasonable cross species estimate of toxicity in the present study, the observation that the responses between ZF and FHM are markedly different does initiate a call for concern regarding establishment of broad ecotoxicological conclusions based on model species such as zebrafish. C1 [Warner, Christopher M.; Gust, Kurt A.; Stanley, Jacob K.; Wilbanks, Mitchell S.; Perkins, Edward J.] USA, Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS USA. [Warner, Christopher M.] Keck Grad Inst, Claremont, CA USA. [Habib, Tanwir] Badger Tech Serv, San Antonio, TX USA. [Garcia-Reyero, Natalia] Mississippi State Univ, Starkville, MS USA. RP Gust, KA (reprint author), USA, Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS USA. EM kurt.a.gust@usace.army.mil FU U.S. Army Environmental Quality Research Program [BAA 08-4379] FX This work was funded by the U.S. Army Environmental Quality Research Program (including BAA 08-4379). Permission for publishing this information has been granted by the Chief of Engineers. NR 52 TC 6 Z9 6 U1 0 U2 20 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0013-936X J9 ENVIRON SCI TECHNOL JI Environ. Sci. Technol. PD JUL 17 PY 2012 VL 46 IS 14 BP 7790 EP 7798 DI 10.1021/es300495c PG 9 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA 974MZ UT WOS:000306441000047 PM 22697906 ER PT J AU Adedeji, OB Durhan, EJ Garcia-Reyero, N Kahl, MD Jensen, KM LaLone, CA Makynen, EA Perkins, EJ Thomas, L Villeneuve, DL Ankley, GT AF Adedeji, Olufemi B. Durhan, Elizabeth J. Garcia-Reyero, Natalia Kahl, Michael D. Jensen, Kathleen M. LaLone, Carlie A. Makynen, Elizabeth A. Perkins, Edward J. Thomas, Linnea Villeneuve, Daniel L. Ankley, Gerald T. TI Short-Term Study Investigating the Estrogenic Potency of Diethylstilbesterol in the Fathead Minnow (Pimephales promelas) SO ENVIRONMENTAL SCIENCE & TECHNOLOGY LA English DT Article ID MESSENGER-RNA; IN-VIVO; VITELLOGENIN; ESTRADIOL; WATER; FISH; ETHYNYLESTRADIOL; ENVIRONMENT; NONYLPHENOL; EXPRESSION AB Diethylstilbestrol (DES) is a synthetic estrogen that has been banned for use in humans, but still is employed in livestock and aquaculture operations in some parts of the world. Detectable concentrations of DES in effluent and surface waters have been reported to range from slightly below 1 to greater than 10 ng/L. Little is known, however, concerning the toxicological potency of DES in fish. In this study, sexually mature fathead minnows (Pimephales promelas) of both sexes were exposed to 1, 10, or 100 ng of DES/L of water in a flow-through system. Tissue concentrations of DES and changes in a number of estrogen-responsive end points were measured in the fish at the end of a 4 d exposure and after a 4 d depuration/recovery period in clean water. Accumulation of DES was sex dependent, with females exhibiting higher tissue residues than males after the 4 d exposure. The observed bioconcentration Of DES in the fish was about 1 order of magnitude lower than that predicted on the basis of the octanol-water partition coefficient of the chemical, suggesting relatively efficient metabolic clearance by the fish. Exposure to 1, 10, or 100 ng of DES/L caused decreased testis weight and morphological demasculinization of males (regression of dorsal nuptial tubercles). Diethylstilbesterol induced plasma vitellogenin (VTG) in both sexes at water concentrations >= 10 ng/L; this response (especially in males) persisted through the end of the 4 d recovery period. Hepatic transcripts of VTG and estrogen receptor-alpha also were affected at DES concentrations >= 10 ng/L. Evaluation of transcript profiles in the liver of females using a 15K gene fathead minnow microarray revealed a concentration dependent change in gene expression, with mostly up regulated transcripts after the exposure and substantial numbers of down-regulated gene products after depuration. genes previously identified as vitellogenesis-related and regulated by 17 beta-estradiol were significantly enriched among those differentially expressed following exposure to DES. Overall, our studies show that DES causes a range of responses in fish at water concentrations comparable to those reported in the environment and that in vivo potency of the estrogen is on par with that of the better-studied estrogenic contaminant 17 alpha-ethinylestradiol. C1 [Durhan, Elizabeth J.; Kahl, Michael D.; Jensen, Kathleen M.; LaLone, Carlie A.; Makynen, Elizabeth A.; Thomas, Linnea; Villeneuve, Daniel L.; Ankley, Gerald T.] US EPA, Midcontinent Ecol Div, Duluth, MN USA. [Adedeji, Olufemi B.] Univ Ibadan, Dept Vet Publ Hlth & Preventat Med, Ibadan, Nigeria. [Garcia-Reyero, Natalia] Mississippi State Univ, Inst Genom Biocomp & Biotechnol, Starkville, MS USA. [Perkins, Edward J.] USA, Ctr Res & Dev, Vicksburg, MS USA. RP Ankley, GT (reprint author), US EPA, Midcontinent Ecol Div, 6201 Congdon Blvd, Duluth, MN USA. EM ankley.gerald@epa.gov FU University of Ibadan/MacArthur Foundation; U.S. Army Environmental Quality Research Program [BAA 11-4838] FX This work was conducted while O.B.A. was a Visiting Scientist from the University of Ibadan (Nigeria), at the U.S. Environmental Protection Agency (USEPA) Mid-Continent Ecology Division in Duluth, MN. He was supported through the University of Ibadan/MacArthur Foundation staff development fund. We acknowledge the assistance of Charles Tyler from the University of Exeter (United Kingdom), who provided unpublished data concerning the in vitro potency of DES in fish. L. Earl Gray, Duane Huggett, and John Nichols provided helpful advice concerning interpretation of the DES data. Matt Weberg assisted with the QPCR analyses, and Lynn Escalon conducted the microarray hybridizations. Joe Tietge provided valuable comments on an earlier version of the manuscript. This work was partly funded by the U.S. Army Environmental Quality Research Program (including Grant BAA 11-4838). NR 44 TC 6 Z9 6 U1 2 U2 24 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0013-936X J9 ENVIRON SCI TECHNOL JI Environ. Sci. Technol. PD JUL 17 PY 2012 VL 46 IS 14 BP 7826 EP 7835 DI 10.1021/es301043b PG 10 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA 974MZ UT WOS:000306441000051 PM 22708615 ER PT J AU Mishra, S Peddada, LY Devore, DI Roth, CM AF Mishra, Swati Peddada, Lavanya Y. Devore, David I. Roth, Charles M. TI Poly(alkylene oxide) Copolymers for Nucleic Acid Delivery SO ACCOUNTS OF CHEMICAL RESEARCH LA English DT Review ID AMPHIPHILIC BLOCK-COPOLYMERS; GENE DELIVERY; IN-VIVO; TRIBLOCK COPOLYMERS; AQUEOUS-SOLUTIONS; PLASMID DNA; TRANSFECTION EFFICIENCY; POLYMERIC MICELLES; SKELETAL-MUSCLE; CELLULAR UPTAKE AB The advancement of gene-based therapeutics to the clinic is limited by the ability to deliver physiologically relevant doses of nucleic adds to target tissues safely and effectively. Over the last couple of decades, researchers have successfully employed polymer and lipid based nanoassemblies to deliver nucleic adds for the treatment of a variety of diseases. Results of phase I/II clinical studies to evaluate the efficacy and biosafety of these gene delivery vehicles have been encouraging, which has promoted the design of more efficient and biocompatible systems. Research has focused on designing carriers to achieve biocompatibility, stability in the circulatory system, biodistribution to target the disease site, and intracellular delivery, all of which enhance the resulting therapeutic effect. The family of poly(alkylene oxide) (PAO) polymers Includes random, block and branched structures, among which the ABA type triblocks copolymers of ethylene oxide (EO) and propylene oxide (PO) (commercially known as Pluronic) have received the greatest consideration. In this Account, we highlight examples of polycation-PAO conjugates, liposome-PAO formulations, and PAO micelles for nucleic add delivery. Among the various polymer design considerations, which include molecular weight of polymer, molecular weight of blocks, and length of blocks, the overall hydrophobic-lipophilic balance (HLB) is a critical parameter in defining the behavior of the polymer conjugates for gene delivery. We discuss the effects of varying this parameter in the context of improving gene delivery processes, such as serum stability and association with cell membranes. Other innovative macromolecular modifications discussed In this category include our work to enhance the serum stability and efficiency of lipoplexes using PAO graft copolymers, the development of a PAO gel-based carrier for sustained and stimuli responsive delivery, and the development of biodegradable PAO-based amphiphilic block copolymers. C1 [Mishra, Swati; Peddada, Lavanya Y.; Roth, Charles M.] Rutgers State Univ, Dept Biomed Engn, Piscataway, NJ 08854 USA. [Roth, Charles M.] Rutgers State Univ, Dept Chem & Biochem Engn, Piscataway, NJ 08854 USA. [Devore, David I.] USA, Inst Surg Res, Battlefield Hlth & Trauma Res Inst, Ft Sam Houston, TX 78234 USA. RP Roth, CM (reprint author), Rutgers State Univ, Dept Biomed Engn, 599 Taylor Rd, Piscataway, NJ 08854 USA. EM cmroth@rutgers.edu OI Roth, Charles/0000-0002-4924-0721 FU National Institutes of Health [EB 008278-07]; Department of Defense [W81-WXH-10-2-0139]; New Jersey State Commission on Cancer Research FX Support for this work was provided under grants from the National Institutes of Health (EB 008278-07) and Department of Defense (W81-WXH-10-2-0139) and a fellowship to LP from the New Jersey State Commission on Cancer Research. The authors thank Dr. Asa Vaughan for synthesis of the PPM graft copolymers and Neil Raju for assistance with figures. NR 60 TC 15 Z9 16 U1 3 U2 54 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0001-4842 J9 ACCOUNTS CHEM RES JI Accounts Chem. Res. PD JUL 17 PY 2012 VL 45 IS 7 BP 1057 EP 1066 DI 10.1021/ar200232n PG 10 WC Chemistry, Multidisciplinary SC Chemistry GA 974NH UT WOS:000306441900012 PM 22260518 ER PT J AU Flanigan, PM Radell, LL Brady, JJ Levis, RJ AF Flanigan, Paul M. Radell, Laine L. Brady, John J. Levis, Robert J. TI Differentiation of Eight Phenotypes and Discovery of Potential Biomarkers for a Single Plant Organ Class Using Laser Electrospray Mass Spectrometry and Multivariate Statistical Analysis SO ANALYTICAL CHEMISTRY LA English DT Article ID ATMOSPHERIC-PRESSURE; AMBIENT CONDITIONS; BIOLOGICAL TISSUE; DISEASE CLASSIFICATION; PROTEOMIC DATA; IONIZATION; ANTHOCYANINS; VAPORIZATION; MS; METABOLITES AB Laser electrospray mass spectrometry (LEMS) coupled with offline multivariate statistical analysis is used to discriminate eight phenotypes from a single plant organ class and to find potential biomarkers. Direct analysis of the molecules from the flower petal is enabled by interfacing intense (10(13) W/cm(2)), nonresonant, femtosecond laser vaporization at ambient pressure with electrospray ionization for postionization of the vaporized analytes. The observed mass spectral signatures allowed for the discrimination of various phenotypes using principal component analysis (PCA) and either linear discriminant analysis (LDA) or K-nearest neighbor (KNN) classifiers. Cross validation was performed using multiple training sets to evaluate the predictive ability of the classifiers, which showed 93.7% and 96.8% overall accuracies for the LDA and KNN classifiers, respectively. Linear combinations of significant mass spectral features were extracted from the PCA loading plots, demonstrating the capability to discover potential biomarkers from the direct analysis of tissue samples. C1 [Flanigan, Paul M.; Radell, Laine L.; Levis, Robert J.] Temple Univ, Dept Chem, Philadelphia, PA 19122 USA. [Brady, John J.] USA, Res Lab, Adelphi, MD 20783 USA. RP Levis, RJ (reprint author), Temple Univ, Dept Chem, 1901 N 13th St, Philadelphia, PA 19122 USA. EM rjlevis@temple.edu FU Office of Naval Research [N00014-10-0293]; National Science Foundation [CHE 0518497, CHE0957694] FX The work was supported by the Office of Naval Research (N00014-10-0293) and the National Science Foundation (CHE 0518497, CHE0957694). J.J.B. acknowledges the Oak Ridge Associated Universities Postdoctoral Research Program. NR 61 TC 13 Z9 13 U1 2 U2 28 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0003-2700 J9 ANAL CHEM JI Anal. Chem. PD JUL 17 PY 2012 VL 84 IS 14 BP 6225 EP 6232 DI 10.1021/ac3012335 PG 8 WC Chemistry, Analytical SC Chemistry GA 974NB UT WOS:000306441200056 PM 22697315 ER PT J AU McLinden, R Paris, R Polonis, V Close, N Su, ZH Shikuma, C Margolis, D Kim, J AF McLinden, Robert Paris, Robert Polonis, Victoria Close, Nicole Su, Zhaohui Shikuma, Cecilia Margolis, David Kim, Jerome TI Association of HIV neutralizing antibody with lower viral load after treatment interruption in a prospective trial (A5170) SO AIDS LA English DT Letter ID HUMAN-IMMUNODEFICIENCY-VIRUS; CELLULAR IMMUNE-RESPONSES; INFECTION C1 [McLinden, Robert] Henry M Jackson Fdn, Rockville, MD USA. [Paris, Robert] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [McLinden, Robert] Henry M Jackson Fdn, Walter Reed Army Inst Res, Dept Mol Virol & Pathogenesis, HIV Mil Res Program, Silver Spring, MD 20910 USA. [Close, Nicole] Empiristat Inc, Mt Airy, MD USA. [Su, Zhaohui] Outcome Sci Inc, Cambridge, MA USA. [Shikuma, Cecilia] Univ Hawaii, JABSOM, Dept Med, Honolulu, HI 96822 USA. [Margolis, David] Univ N Carolina, Chapel Hill, NC USA. [Kim, Jerome] Henry M Jackson Fdn, Walter Reed Army Inst Res, Dept Mol Virol & Pathogenesis, Mil Res Program, Silver Spring, MD 20910 USA. RP McLinden, R (reprint author), Henry M Jackson Fdn, Walter Reed Army Inst Res, Dept Mol Virol & Pathogenesis, HIV Mil Res Program, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM rmclinden@hivresearch.org OI Margolis, David/0000-0001-5714-0002 FU NCRR NIH HHS [G12 RR003061] NR 10 TC 3 Z9 3 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0269-9370 J9 AIDS JI Aids PD JUL 17 PY 2012 VL 26 IS 11 BP 1452 EP 1452 DI 10.1097/QAD.0b013e3283550b8e PG 1 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA 970LO UT WOS:000306130700021 PM 22767347 ER PT J AU Lawhern, V Hairston, WD McDowell, K Westerfield, M Robbins, K AF Lawhern, Vernon Hairston, W. David McDowell, Kaleb Westerfield, Marissa Robbins, Kay TI Detection and classification of subject-generated artifacts in EEG signals using autoregressive models SO JOURNAL OF NEUROSCIENCE METHODS LA English DT Article DE Autoregressive model; Artifacts; Electroencephalography; Support vector machines ID INDEPENDENT COMPONENT ANALYSIS; FALSE DISCOVERY RATE; SYSTEM AB We examine the problem of accurate detection and classification of artifacts in continuous EEG recordings. Manual identification of artifacts, by means of an expert or panel of experts, can be tedious, time-consuming and infeasible for large datasets. We use autoregressive (AR) models for feature extraction and characterization of EEG signals containing several kinds of subject-generated artifacts. AR model parameters are scale-invariant features that can be used to develop models of artifacts across a population. We use a support vector machine (SVM) classifier to discriminate among artifact conditions using the AR model parameters as features. Results indicate reliable classification among several different artifact conditions across subjects (approximately 94%). These results suggest that AR modeling can be a useful tool for discriminating among artifact signals both within and across individuals. (C) 2012 Elsevier B.V. All rights reserved. C1 [Lawhern, Vernon; Robbins, Kay] Univ Texas San Antonio, Dept Comp Sci, San Antonio, TX 78249 USA. [Hairston, W. David; McDowell, Kaleb] USA, Res Lab, Human Res & Engn Directorate, Aberdeen Proving Ground, MD 21005 USA. [Westerfield, Marissa] Univ Calif San Diego, Dept Neurosci, La Jolla, CA 92093 USA. RP Lawhern, V (reprint author), Univ Texas San Antonio, Dept Comp Sci, San Antonio, TX 78249 USA. EM vlawhern@cs.utsa.edu; william.d.hairston4.civ@mail.mil; kaleb.g.mcdowell.civ@mail.mil; mwesterfield@ucsd.edu; krobbins@cs.utsa.edu OI Hairston, W. David/0000-0003-4432-8430 FU Army Research Laboratory; [W911NF-10-2-0022] FX We thank Scott Kerick, Anthony Ries and Jean Vettel of the Army Research Laboratory for helpful discussions and for help with data collection. This research was sponsored by the Army Research Laboratory and was accomplished under Cooperative Agreement Number W911NF-10-2-0022. The views and conclusions contained in this document are those of the authors and should not be interpreted as representing the official policies, either expressed or implied, of the Army Research Laboratory or the U.S. Government. The U.S. Government is authorized to reproduce and distribute reprints for Government purposes notwithstanding any copyright notation herein. NR 28 TC 25 Z9 27 U1 1 U2 9 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0165-0270 J9 J NEUROSCI METH JI J. Neurosci. Methods PD JUL 15 PY 2012 VL 208 IS 2 BP 181 EP 189 DI 10.1016/j.jneumeth.2012.05.017 PG 9 WC Biochemical Research Methods; Neurosciences SC Biochemistry & Molecular Biology; Neurosciences & Neurology GA 980GY UT WOS:000306882800013 PM 22634706 ER PT J AU Vorontsov, M Weyrauch, T Lachinova, S Gatz, M Carhart, G AF Vorontsov, Mikhail Weyrauch, Thomas Lachinova, Svetlana Gatz, Micah Carhart, Gary TI Speckle-metric-optimization-based adaptive optics for laser beam projection and coherent beam combining SO OPTICS LETTERS LA English DT Article ID PHASE-DISTORTION CORRECTION; PROPAGATION; SYSTEMS; TARGET AB Maximization of a projected laser beam's power density at a remotely located extended object (speckle target) can be achieved by using an adaptive optics (AO) technique based on sensing and optimization of the target-return speckle field's statistical characteristics, referred to here as speckle metrics (SM). SM AO was demonstrated in a target-in-the-loop coherent beam combining experiment using a bistatic laser beam projection system composed of a coherent fiber-array transmitter and a power-in-the-bucket receiver. SM sensing utilized a 50 MHz rate dithering of the projected beam that provided a stair-mode approximation of the outgoing combined beam's wavefront tip and tilt with subaperture piston phases. Fiber-integrated phase shifters were used for both the dithering and SM optimization with stochastic parallel gradient descent control. (c) 2012 Optical Society of America C1 [Vorontsov, Mikhail; Weyrauch, Thomas; Gatz, Micah] Univ Dayton, Intelligent Opt Lab, Sch Engn, Dayton, OH 45469 USA. [Vorontsov, Mikhail; Lachinova, Svetlana] Optonicus, Dayton, OH 45402 USA. [Carhart, Gary] USA, Intelligent Opt Lab, Computat & Informat Sci Directorate, Res Lab, Adelphi, MD 20783 USA. RP Vorontsov, M (reprint author), Univ Dayton, Intelligent Opt Lab, Sch Engn, 300 Coll Pk, Dayton, OH 45469 USA. EM mikhail.vorontsov@udayton.edu FU United States Army Research Laboratory [W911NF-09-2-0040]; University of Dayton [W911NF-09-2-0040] FX This work was performed in part through collaborative agreement W911NF-09-2-0040 between the United States Army Research Laboratory and the University of Dayton. NR 15 TC 6 Z9 7 U1 1 U2 13 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 0146-9592 J9 OPT LETT JI Opt. Lett. PD JUL 15 PY 2012 VL 37 IS 14 BP 2802 EP 2804 PG 3 WC Optics SC Optics GA 978AH UT WOS:000306709900011 PM 22825139 ER PT J AU Liesemer, K Casper, TC Korgenski, K Menon, SC AF Liesemer, Kirk Casper, T. Charles Korgenski, Kent Menon, Shaji C. TI Use and Misuse of Serum Troponin Assays in Pediatric Practice SO AMERICAN JOURNAL OF CARDIOLOGY LA English DT Review ID HEART-ASSOCIATION ELECTROCARDIOGRAPHY; FOR-COMPUTERIZED-ELECTROCARDIOLOGY; OF-CARDIOLOGY FOUNDATION; AHA/ACCF/HRS RECOMMENDATIONS; ANTHRACYCLINE CHEMOTHERAPY; MYOCARDIAL DYSFUNCTION; ARRHYTHMIAS COMMITTEE; SCIENTIFIC STATEMENT; CLINICAL CARDIOLOGY; KAWASAKI-DISEASE AB Cardiac troponin (cTn) is instrumental in screening and diagnosing myocardial ischemia in adults. However, the role of cTn screening in the pediatric population is less clear. The purpose of this study was to evaluate the current clinical practice, diagnostic and prognostic value, and resource utilization associated with cTn assays in the pediatric population. A multicenter, retrospective review of all cTn assays performed on patients aged <= 18 years from January 2003 to December 2010 in the Intermountain Healthcare system was conducted. Data collected included patient demographics, location, presenting symptoms, provisional and discharge diagnoses, additional tests, clinical outcomes (hospitalization days, ventilation, and death), and patient charges. During the study period, cTn assays were performed on 3,497 pediatric patients. The most common presenting diagnoses were chest pain (40%), trauma (11%), and poisoning or drug overdose (9%). Irrespective of diagnosis, elevated cTn was associated with an increased rate of hospitalization, ventilation, and death. Overall, 12% of patients had elevated cTn. Of the patients with chest pain, 4% had elevated cTn, 53% of whom were diagnosed with myopericarditis. In the myopericarditis group, 66% presented with fever, and 98% had abnormal electrocardiographic findings. For patients presenting with chest pain, approximately $162,000 was spent per positive result. In conclusion, cTn screening has strong prognostic value in pediatric patients, even in noncardiac diagnoses such as trauma or drug overdose. However, cTn screening in pediatric patients with chest pain provides minimal benefits and is associated with increased resource utilization, unless patients have constitutional symptoms, such as fever and/or electrocardiographic abnormalities. Published by Elsevier Inc. (Am J Cardiol 2012;110:284-289) C1 [Liesemer, Kirk; Menon, Shaji C.] Univ Utah, Div Pediat Cardiol, Salt Lake City, UT 84112 USA. [Casper, T. Charles; Korgenski, Kent] Univ Utah, Dept Pediat, Salt Lake City, UT USA. [Liesemer, Kirk] USA, Med Corps, Washington, DC USA. RP Liesemer, K (reprint author), Univ Utah, Div Pediat Cardiol, Salt Lake City, UT 84112 USA. EM kirk.liesemer@imail.org NR 29 TC 6 Z9 7 U1 0 U2 4 PU EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC PI BRIDGEWATER PA 685 ROUTE 202-206 STE 3, BRIDGEWATER, NJ 08807 USA SN 0002-9149 J9 AM J CARDIOL JI Am. J. Cardiol. PD JUL 15 PY 2012 VL 110 IS 2 BP 284 EP 289 DI 10.1016/j.amjcard.2012.03.020 PG 6 WC Cardiac & Cardiovascular Systems SC Cardiovascular System & Cardiology GA 982FX UT WOS:000307029500021 PM 22537355 ER PT J AU Alves, DA AF Alves, Derron A. TI Pathology in Practice SO JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION LA English DT Editorial Material ID PIG CAVIA-PORCELLANUS; GUINEA-PIGS; UROLITHIASIS; CYSTITIS; CALCULI C1 USA, Comparat Pathol Branch, Med Res Inst Chem Def, Edgewood, MD 21010 USA. RP Alves, DA (reprint author), USA, Comparat Pathol Branch, Med Res Inst Chem Def, 3100 Ricketts Point Rd, Edgewood, MD 21010 USA. EM derron.a.alves@us.army.mil NR 9 TC 0 Z9 0 U1 1 U2 2 PU AMER VETERINARY MEDICAL ASSOC PI SCHAUMBURG PA 1931 N MEACHAM RD SUITE 100, SCHAUMBURG, IL 60173-4360 USA SN 0003-1488 J9 JAVMA-J AM VET MED A JI JAVMA-J. Am. Vet. Med. Assoc. PD JUL 15 PY 2012 VL 241 IS 2 BP 185 EP 187 PG 3 WC Veterinary Sciences SC Veterinary Sciences GA 971ZN UT WOS:000306246400005 PM 22765364 ER PT J AU Valcour, V Chalermchai, T Sailasuta, N Marovich, M Lerdlum, S Suttichom, D Suwanwela, NC Jagodzinski, L Michael, N Spudich, S van Griensven, F de Souza, M Kim, J Ananworanich, J AF Valcour, Victor Chalermchai, Thep Sailasuta, Napapon Marovich, Mary Lerdlum, Sukalaya Suttichom, Duanghathai Suwanwela, Nijasri C. Jagodzinski, Linda Michael, Nelson Spudich, Serena van Griensven, Frits de Souza, Mark Kim, Jerome Ananworanich, Jintanat CA RV254 SEARCH 010 Study Grp TI Central Nervous System Viral Invasion and Inflammation During Acute HIV Infection SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article ID IMMUNODEFICIENCY-VIRUS INFECTION; NEUROPSYCHOLOGICAL IMPAIRMENT; ANTIRETROVIRAL THERAPY; RISK-FACTORS; FLUID LEVELS; DEMENTIA; BRAIN; SPECTROSCOPY; REPLICATION; PROGRESSION AB Background. Understanding the earliest central nervous system (CNS) events during human immunodeficiency virus (HIV) infection is crucial to knowledge of neuropathogenesis, but these have not previously been described in humans. Methods. Twenty individuals who had acute HIV infection (Fiebig stages I-IV), with average 15 days after exposure, underwent clinical neurological, cerebrospinal fluid (CSF), magnetic resonance imaging, and magnetic resonance spectroscopy (MRS) characterization. Results. HIV RNA was detected in the CSF from 15 of 18 subjects as early as 8 days after estimated HIV transmission. Undetectable CSF levels of HIV (in 3 of 18) was noted during Fiebig stages I, II, and III, with plasma HIV RNA levels of 285 651, 2321, and 81 978 copies/mL, respectively. On average, the CSF HIV RNA level was 2.42 log(10) copies/mL lower than that in plasma. There were no cases in which the CSF HIV RNA level exceeded that in plasma. Headache was common during the acute retroviral syndrome (in 11 of 20 subjects), but no other neurological signs or symptoms were seen. Intrathecal immune activation was identified in some subjects with elevated CSF neopterin, monocyte chemotactic protein/CCL2, and interferon gamma-induced protein 10/CXCL-10 levels. Brain inflammation was suggested by MRS. Conclusions. CSF HIV RNA was detectable in humans as early as 8 days after exposure. CNS inflammation was apparent by CSF analysis and MRS in some individuals during acute HIV infection. C1 [Valcour, Victor] Univ Calif San Francisco, Dept Neurol, Memory & Aging Ctr, San Francisco, CA 94143 USA. [Valcour, Victor] Univ Calif San Francisco, Dept Med, Div Geriatr Med, San Francisco, CA 94143 USA. [Chalermchai, Thep; Suttichom, Duanghathai; Ananworanich, Jintanat] SEARCH, Bangkok, Thailand. [Sailasuta, Napapon] Huntington Med Res Inst, Pasadena, CA USA. [Marovich, Mary; Jagodzinski, Linda; Michael, Nelson] Walter Reed Army Inst Res, Mil HIV Res Program, Rockville, MD USA. [Lerdlum, Sukalaya; Suwanwela, Nijasri C.; Kim, Jerome; Ananworanich, Jintanat] Chulalongkorn Univ, Fac Med, Bangkok 10330, Thailand. [Lerdlum, Sukalaya; Suwanwela, Nijasri C.; Kim, Jerome] King Chulalongkorn Mem Hosp, Dept Radiol, Bangkok, Thailand. [Spudich, Serena] Yale Univ, Sch Med, Dept Neurol, New Haven, CT 06510 USA. [van Griensven, Frits] Thailand Minist Publ Hlth CDC Collaborat, Nonthaburi, Thailand. [van Griensven, Frits] Ctr Dis Control & Prevent, Div HIV AIDS Prevent, CDC, Atlanta, GA USA. [de Souza, Mark] Armed Forces Res Inst Med Sci US Component, Dept Retrovirol, Bangkok, Thailand. [Ananworanich, Jintanat] US Armed Forces Res Inst Med Sci, Bangkok, Thailand. [Ananworanich, Jintanat] HIV Netherlands Australia Thailand Res Collaborat, Bangkok, Thailand. [Chalermchai, Thep; Suttichom, Duanghathai; Ananworanich, Jintanat] Thai Red Cross AIDS Res Ctr, Bangkok, Thailand. RP Valcour, V (reprint author), UCSF Memory & Aging Ctr, Ste 905,350 Parnassus Ave, San Francisco, CA 94143 USA. EM Vvalcour@memory.ucsf.edu RI van Griensven, Frits/G-4719-2013 OI van Griensven, Frits/0000-0002-0971-2843 FU National Institute of Mental Health [NIH-R21 MH086341]; Military HIV Research Program, Walter Reed Army Institute of Research (Rockville, MD); Henry M. Jackson Foundation for the Advancement of Military Medicine [W81XWH-07-2-0067]; US Department of Defense [W81XWH-07-2-0067]; Intramural research program of the NIAID; Intramural research program of the Vaccine and Gene Therapy Institute; Gilead (Truvada, Atripla); Merck (Sustiva, Isentress); Pfizer (Selzentry) FX This work was supported by the National Institute of Mental Health (NIH-R21 MH086341). The Military HIV Research Program, Walter Reed Army Institute of Research (Rockville, MD), funded the main acute HIV study. This work was supported by a cooperative agreement (W81XWH-07-2-0067) between the Henry M. Jackson Foundation for the Advancement of Military Medicine and the US Department of Defense. This work was also supported in part by the Intramural research programs of the NIAID and of the Vaccine and Gene Therapy Institute. Antiretroviral therapy was supported by Gilead (Truvada, Atripla), Merck (Sustiva, Isentress), and Pfizer (Selzentry). Monogram Biosciences supported the Trofile test. NR 32 TC 116 Z9 117 U1 0 U2 6 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD JUL 15 PY 2012 VL 206 IS 2 BP 275 EP 282 DI 10.1093/infdis/jis326 PG 8 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 963MX UT WOS:000305626200016 PM 22551810 ER PT J AU Panigrahi, SK Kumar, K Kumar, N Yuan, W Mishra, RS DeLorme, R Davis, B Howell, RA Cho, K AF Panigrahi, S. K. Kumar, K. Kumar, N. Yuan, W. Mishra, R. S. DeLorme, R. Davis, B. Howell, R. A. Cho, K. TI Transition of deformation behavior in an ultrafine grained magnesium alloy SO MATERIALS SCIENCE AND ENGINEERING A-STRUCTURAL MATERIALS PROPERTIES MICROSTRUCTURE AND PROCESSING LA English DT Article DE Magnesium alloys; Ultrafine grained alloys; Deformation mechanism; Friction stir processing ID MG-3AL-1ZN ALLOY; MECHANICAL-PROPERTIES; NANOCRYSTALLINE METALS; TENSILE DEFORMATION; PLASTIC-DEFORMATION; SIZE DEPENDENCE; YIELD ASYMMETRY; ALUMINUM; STRENGTH; DUCTILITY AB The deformation behavior of friction stir processed magnesium alloy with average grain size ranging from 25 mu m to 240 nm was studied. An evaluation of critical grain size for transition of deformation mode from twinning to slip was carried out by employing tensile and compressive tests. The role of critical grain size in transition of deformation behavior from strain hardening to softening was established. Inhomogeneous yielding was observed during tensile test of ultrafine-grained magnesium alloy below the critical grain size. (C) 2012 Elsevier B.V. All rights reserved. C1 [Panigrahi, S. K.; Kumar, K.; Kumar, N.; Yuan, W.; Mishra, R. S.] Missouri Univ Sci & Technol, Ctr Frict Stir Proc, Rolla, MO 65409 USA. [Panigrahi, S. K.; Kumar, K.; Kumar, N.; Yuan, W.; Mishra, R. S.] Missouri Univ Sci & Technol, Dept Mat Sci & Engn, Rolla, MO 65409 USA. [DeLorme, R.; Davis, B.] Magnesium Elektron N Amer Inc, Madison, IL 62060 USA. [Howell, R. A.; Cho, K.] USA, Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. RP Mishra, RS (reprint author), Missouri Univ Sci & Technol, Ctr Frict Stir Proc, Rolla, MO 65409 USA. EM rajiv.mishra@unt.edu RI Mishra, Rajiv/A-7985-2009 OI Mishra, Rajiv/0000-0002-1699-0614 FU U.S. Army Research Laboratory [W911NF-07-2-0073] FX Research was sponsored by U.S. Army Research Laboratory and was accomplished under Cooperative Agreement W911NF-07-2-0073. The views, opinions, and conclusions made in this document are those of the authors and should not be interpreted as representing the official policies, either expressed or implied, of Army Research Laboratory or the U.S. Government. The U.S. Government is authorized to reproduce and distribute reprints for Government purposes notwithstanding any copyright notation herein. NR 41 TC 7 Z9 8 U1 2 U2 12 PU ELSEVIER SCIENCE SA PI LAUSANNE PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND SN 0921-5093 J9 MAT SCI ENG A-STRUCT JI Mater. Sci. Eng. A-Struct. Mater. Prop. Microstruct. Process. PD JUL 15 PY 2012 VL 549 BP 123 EP 127 DI 10.1016/j.msea.2012.04.017 PG 5 WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Science & Technology - Other Topics; Materials Science; Metallurgy & Metallurgical Engineering GA 960FQ UT WOS:000305373800018 ER PT J AU Lucca, JJD Chavko, M Dubick, MA Adeeb, S Falabella, MJ Slack, JL McCarron, R Li, YS AF Lucca, Jurandir J. Dalle Chavko, Mikulas Dubick, Michael A. Adeeb, Saleena Falabella, Michael J. Slack, Jessica L. McCarron, Richard Li, Yansong TI Blast-induced moderate neurotrauma (BINT) elicits early complement activation and tumor necrosis factor alpha (TNF alpha) release in a rat brain SO JOURNAL OF THE NEUROLOGICAL SCIENCES LA English DT Article DE Blast overpressure; Blast-induced neurotrauma; Complement activation; Edema; Inflammatory cytokine; Leukocyte infiltration ID INJURY-INDUCED NEUROTRAUMA; MEMBRANE ATTACK; OVERPRESSURE; EXPRESSION; CONTUSION; INCREASE; TRAUMA; SYSTEM; EDEMA; CELLS AB Blast-induced neurotrauma (BINT) is a major medical concern yet its etiology is largely undefined. Complement activation may play a role in the development of secondary injury following traumatic brain injury; however, its role in BINT is still undefined. The present study was designed to characterize the complement system and adaptive immune-inflammatory responses in a rat model of moderate BINT. Anesthetized rats were exposed to a moderate blast (120 kPa) using an air-driven shock tube. Brain tissue injury, systemic and local complement, cerebral edema, inflammatory cell infiltration, and pro-inflammatory cytokine production were measured at 0.5, 3, 48, 72, 120, and 168 h. Injury to brain tissue was evaluated by histological evaluation. Systemic complement was measured via ELSIA. The remaining measurements were determined by immunohistoflourescent staining. Moderate blast triggers moderate brain injuries, elevated levels of local brain C3/C5b-9 and systemic C5b-9, increased leukocyte infiltration, unregulated tumor necrosis factor alpha (TNF alpha), and aquaporin-4 in rat brain cortex at 3- and 48-hour post blast. Early immune-inflammatory response to BINT involves complement and TNF alpha, which correlates with hippocampus and cerebral cortex damage. Complement and TNF alpha activation may be a novel therapeutic target for reducing the damaging effects of BINT inflammation. Published by Elsevier B.V. C1 [Lucca, Jurandir J. Dalle; Dubick, Michael A.; Falabella, Michael J.; Slack, Jessica L.; Li, Yansong] USA, Inst Surg Res, Immunomodulat Trauma Program, Ft Sam Houston, TX 78234 USA. [Chavko, Mikulas; Adeeb, Saleena; McCarron, Richard] USN, Dept Trauma & Resuscitat Med, Med Res Ctr, Silver Spring, MD 20910 USA. RP Lucca, JJD (reprint author), USA, Inst Surg Res, Immunomodulat Trauma Program, 3650 Chambers Pass,BHT2,Bldg 3610, Ft Sam Houston, TX 78234 USA. EM Jurandir.dallelucca@us.army.mil FU Defense Medical Research and Development Program (DMRDP); US Army Medical Research and Materiel Command Combat Casualty Care Research Program; Office of Naval Research FX This study was funded by the Defense Medical Research and Development Program (DMRDP) and US Army Medical Research and Materiel Command Combat Casualty Care Research Program and the Office of Naval Research. NR 35 TC 16 Z9 16 U1 0 U2 7 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0022-510X J9 J NEUROL SCI JI J. Neurol. Sci. PD JUL 15 PY 2012 VL 318 IS 1-2 BP 146 EP 154 DI 10.1016/j.jns.2012.02.002 PG 9 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA 964BK UT WOS:000305668500025 ER PT J AU Huang, XZ Frye, JG Chahine, MA Glenn, LM Ake, JA Su, WW Nikolich, MP Lesho, EP AF Huang, Xiao-Zhe Frye, Jonathan G. Chahine, Mohamad A. Glenn, LaShanda M. Ake, Julie A. Su, Wanwen Nikolich, Mikeljon P. Lesho, Emil P. TI Characteristics of Plasmids in Multi-Drug-Resistant Enterobacteriaceae Isolated during Prospective Surveillance of a Newly Opened Hospital in Iraq SO PLOS ONE LA English DT Article ID ANTIBIOTIC-RESISTANCE; SALMONELLA-ENTERICA; GENES; MICROARRAY; EPIDEMIOLOGY; ENVIRONMENT; WORLDWIDE; INTEGRONS AB Background: Gram-negative multidrug-resistant (MDR) bacteria are major causes of nosocomial infections, and antibiotic resistance in these organisms is often plasmid mediated. Data are scarce pertaining to molecular mechanisms of antibiotic resistance in resource constrained areas such as Iraq. Methodology/Principal Findings: In this study, all MDR Enterobacteriaceae (n = 38) and randomly selected non-MDR counterparts (n = 41) isolated from patients, healthcare workers and environmental surfaces in a newly opened hospital in Iraq were investigated to characterize plasmids found in these isolates and determine their contribution to antibiotic resistance. Our results demonstrated that MDR E. coli and K. pneumoniae isolates harbored significantly more (>= 3) plasmids compared to their non-MDR counterparts, which carried <= 2 plasmids (p<0.01). Various large plasmids (similar to 52 to 100 kb) from representative isolates were confirmed to contain multiple resistance genes by DNA microarray analysis. Aminoglycoside (acc, aadA, aph, strA/B, and ksgA), beta-lactam (bla(TEM1), bla(AMPC), bla(CTX-M-15), bla(OXA-1), bla(VIM-2) and bla(SHV)), sulfamethoxazole/trimethoprim (sul/dfr), tetracycline (tet) and chloramphenicol (cat) resistance genes were detected on these plasmids. Additionally, multiple plasmids carrying multiple antibiotic resistance genes were found in the same host strain. Genetic transfer-associated genes were identified on the plasmids from both MDR and non-MDR isolates. Seven plasmid replicon types (FII, FIA, FIB, B/O, K, I1 and N) were detected in the isolates, while globally disseminated IncA/C and IncHI1 plasmids were not detected in these isolates. Conclusions/Significance: This is the first report of the characteristics of the plasmids found in Enterobacteriaceae isolated following the opening of a new hospital in Iraq. The information provided here furthers our understanding of the mechanisms of drug resistance in this specific region and their evolutionary relationship with other parts of world. The large plasmids, carrying resistance genes and transfer-associated genes, may be potential factors for regional dissemination of antibiotic resistance. C1 [Huang, Xiao-Zhe; Chahine, Mohamad A.; Su, Wanwen; Nikolich, Mikeljon P.; Lesho, Emil P.] Walter Reed Army Inst Res, Bacterial Dis Branch, Silver Spring, MD USA. [Frye, Jonathan G.; Glenn, LaShanda M.] ARS, Bacterial Epidemiol & Antidrug Resistant Unit, USDA, Athens, GA USA. [Ake, Julie A.] Walter Reed Army Med Ctr, Infect Dis Serv, Washington, DC 20307 USA. RP Huang, XZ (reprint author), Walter Reed Army Inst Res, Bacterial Dis Branch, Silver Spring, MD USA. EM xiaozhe.huang1.ctr@us.army.mil RI Valle, Ruben/A-7512-2013; Frye, Jonathan/I-6382-2013 OI Frye, Jonathan/0000-0002-8500-3395 FU Military Infectious Diseases Research Program (MIDRP); Global Emerging Infectious Diseases Surveillance and Response (GEIS), U.S. Department of Defense (DOD) FX This study was supported by the Military Infectious Diseases Research Program (MIDRP), and the Global Emerging Infectious Diseases Surveillance and Response (GEIS), U.S. Department of Defense (DOD). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 30 TC 5 Z9 6 U1 1 U2 15 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD JUL 11 PY 2012 VL 7 IS 7 AR e40360 DI 10.1371/journal.pone.0040360 PG 8 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 973LU UT WOS:000306362400045 PM 22808141 ER PT J AU Auliff, AM Balu, B Chen, NH O'Neil, MT Cheng, Q Adams, JH AF Auliff, Alyson M. Balu, Bharath Chen, Nanhua O'Neil, Michael T. Cheng, Qin Adams, John H. TI Functional Analysis of Plasmodium vivax Dihydrofolate Reductase-Thymidylate Synthase Genes through Stable Transformation of Plasmodium falciparum SO PLOS ONE LA English DT Article ID HUMAN MALARIA PARASITE; PAPUA-NEW-GUINEA; SULFADOXINE-PYRIMETHAMINE; IN-VITRO; ANTIFOLATE RESISTANCE; THERAPEUTIC RESPONSE; EXPRESSION SYSTEM; CHLOROQUINE; MUTATIONS; ANTIMALARIAL AB Mechanisms of drug resistance in Plasmodium vivax have been difficult to study partially because of the difficulties in culturing the parasite in vitro. This hampers monitoring drug resistance and research to develop or evaluate new drugs. There is an urgent need for a novel method to study mechanisms of P. vivax drug resistance. In this paper we report the development and application of the first Plasmodium falciparum expression system to stably express P. vivax dhfr-ts alleles. We used the piggyBac transposition system for the rapid integration of wild-type, single mutant (117N) and quadruple mutant (57L/58R/61M/117T) pvdhfr-ts alleles into the P. falciparum genome. The majority (81%) of the integrations occurred in non-coding regions of the genome; however, the levels of pvdhfr transcription driven by the P. falciparum dhfr promoter were not different between integrants of non-coding and coding regions. The integrated quadruple pvdhfr mutant allele was much less susceptible to antifolates than the wild-type and single mutant pvdhfr alleles. The resistance phenotype was stable without drug pressure. All the integrated clones were susceptible to the novel antifolate JPC-2067. Therefore, the piggyBac expression system provides a novel and important tool to investigate drug resistance mechanisms and gene functions in P. vivax. C1 [Auliff, Alyson M.; Chen, Nanhua; Cheng, Qin] Australian Army Malaria Inst, Drug Resistance & Diagnost Dept, Enoggera, Qld, Australia. [Auliff, Alyson M.; Cheng, Qin] Univ Queensland, Sch Populat Hlth, Brisbane, Qld, Australia. [Balu, Bharath; Adams, John H.] Univ S Florida, Dept Global Hlth, Tampa, FL USA. [O'Neil, Michael T.] Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD USA. RP Auliff, AM (reprint author), Australian Army Malaria Inst, Drug Resistance & Diagnost Dept, Enoggera, Qld, Australia. EM qin.cheng@defence.gov.au; jadams3@health.usf.edu RI Adams, John/G-1800-2015 OI Adams, John/0000-0003-3707-7979 FU National Institutes of Health [R21AI070888, R01AI033656]; Australian American Fulbright Scholarship; Chief of Army Scholarship; ARC/NHMRC Parasitology Network FX The work was supported in part by National Institutes of Health grants R21AI070888 and R01AI033656 (JHA). AMA received travel awards from the Australian American Fulbright Scholarship (2009), Chief of Army Scholarship (2009) and ARC/NHMRC Parasitology Network travel scholarship (2006). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. No additonal external funding received for this study. NR 62 TC 3 Z9 4 U1 0 U2 0 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD JUL 9 PY 2012 VL 7 IS 7 AR e40416 DI 10.1371/journal.pone.0040416 PG 11 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 973IV UT WOS:000306354700044 PM 22792308 ER PT J AU Alexson, DA Hickman, SA Marohn, JA Smith, DD AF Alexson, Dimitri A. Hickman, Steven A. Marohn, John A. Smith, Doran D. TI Single-shot nuclear magnetization recovery curves with force-gradient detection SO APPLIED PHYSICS LETTERS LA English DT Article ID ULTRASENSITIVE CANTILEVERS; FIBEROPTIC INTERFEROMETER; RESONANCE; RELAXATION; MICROSCOPY; GAAS; TIPS AB We measure the spin-lattice relaxation time as a function of sample temperature in GaAs in a real-time single-shot inversion recovery experiment using spin force gradients acting on a magnetic tipped cantilever. After inverting Ga-69 spins localized near the magnet with a single 20 ms adiabatic rapid passage sweep, the spins' magnetization recovery was passively tracked by recording the cantilever's frequency change, which is proportional to the longitudinal component of the spins' magnetization. The cantilever's frequency was recorded for a time 3*T-1 for sample temperatures ranging from 4.8 to 25 K. The temperature dependence was observed for the Ga-69 quadrupolar relaxation interaction. (C) 2012 American Institute of Physics. [http://dx.doi.org/10.1063/1.4730610] C1 [Alexson, Dimitri A.; Smith, Doran D.] USA, Res Lab, Adelphi, MD 20783 USA. [Hickman, Steven A.; Marohn, John A.] Cornell Univ, Dept Chem & Chem Biol, Ithaca, NY 14853 USA. [Hickman, Steven A.] Harvard Univ, Ctr Nanoscale Syst, Cambridge, MA 02138 USA. RP Alexson, DA (reprint author), USA, Res Lab, Adelphi, MD 20783 USA. FU DOE NNSA Office of Nonproliferation and Verification RD; National Science Foundation [ECS-0335765] FX The authors would like to graciously thank Jeff Pulskamp for modeling the vibration behavior of parts of the probe head, Peter Newman for the GaAs crystal growth, Mathew Erwin for Au coating the sample, the DOE NNSA Office of Nonproliferation and Verification R&D for partial funding of the work, and Dr. Nicholas Fell for his support. Cantilevers were fabricated at the Cornell NanoScale Science and Technology Facility, a member of the National Nanotechnology Infrastructure Network, supported by the National Science Foundation (ECS-0335765). J.A.M. acknowledges the National Institutes of Health (5R01GM-070012) and S. A. H. and J.A.M. acknowledge the Army Research Office Multi-university Research Initiative (W911NF-05-1-0403). NR 25 TC 5 Z9 5 U1 0 U2 13 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD JUL 9 PY 2012 VL 101 IS 2 AR 022103 DI 10.1063/1.4730610 PG 4 WC Physics, Applied SC Physics GA 973LC UT WOS:000306360600036 PM 26130824 ER PT J AU Lapchak, PH Ioannou, A Rani, P Lieberman, LA Yoshiya, K Kannan, L Lucca, JJD Kowalska, MA Tsokos, GC AF Lapchak, Peter H. Ioannou, Antonis Rani, Poonam Lieberman, Linda A. Yoshiya, Kazuhisa Kannan, Lakshmi Lucca, Jurandir J. Dalle Kowalska, M. Anna Tsokos, George C. TI The Role of Platelet Factor 4 in Local and Remote Tissue Damage in a Mouse Model of Mesenteric Ischemia/Reperfusion Injury SO PLOS ONE LA English DT Article ID CXC-CHEMOKINE PLATELET-FACTOR-4; INFLAMMATORY-BOWEL-DISEASE; HUMAN PLATELET FACTOR-4; ISCHEMIA-REPERFUSION; HUMAN MONOCYTES; FACTOR-IV; MICE; CELLS; ATHEROSCLEROSIS; DIFFERENTIATION AB The robust inflammatory response that occurs during ischemia reperfusion (IR) injury recruits factors from both the innate and adaptive immune systems. However the contribution of platelets and their products such as Platelet Factor 4 (PF4; CXCL4), during the pathogenesis of IR injury has not been thoroughly investigated. We show that a deficiency in PF4 protects mice from local and remote tissue damage after 30 minutes of mesenteric ischemia and 3 hours of reperfusion in PF4-/- mice compared to control B6 mice. This protection was independent from Ig or complement deposition in the tissues. However, neutrophil and monocyte infiltration were decreased in the lungs of PF4-/- mice compared with B6 control mice. Platelet-depleted B6 mice transfused with platelets from PF4-/- mice displayed reduced tissue damage compared with controls. In contrast, transfusion of B6 platelets into platelet depleted PF4-/- mice reconstituted damage in both intestine and lung tissues. We also show that PF4 may modulate the release of IgA. Interestingly, we show that PF4 expression on intestinal epithelial cells is increased after IR at both the mRNA and protein levels. In conclusion, these findings demonstrate that may PF4 represent an important mediator of local and remote tissue damage. C1 [Lapchak, Peter H.; Ioannou, Antonis; Rani, Poonam; Lieberman, Linda A.; Yoshiya, Kazuhisa; Kannan, Lakshmi; Tsokos, George C.] Beth Israel Deaconess Med Ctr, Div Rheumatol, Boston, MA 02215 USA. [Lapchak, Peter H.; Ioannou, Antonis; Rani, Poonam; Lieberman, Linda A.; Yoshiya, Kazuhisa; Kannan, Lakshmi; Tsokos, George C.] Harvard Univ, Sch Med, Boston, MA USA. [Kowalska, M. Anna] Univ Penn, Childrens Hosp Philadelphia, Sch Med, Dept Pediat, Philadelphia, PA 19104 USA. [Lucca, Jurandir J. Dalle] USA, Inst Surg Res, San Antonio, TX USA. RP Lapchak, PH (reprint author), Beth Israel Deaconess Med Ctr, Div Rheumatol, Boston, MA 02215 USA. EM aioannou@bicmc.harvard.edu; gtsokos@bidmc.harvard.edu OI Lapchak, Peter/0000-0001-8597-088X FU Medical Research and Material Command of the Department of the Army [W81XWH-09-1-0530, W81XWH-09-1-0536] FX The research presented herein was supported by Grant numbers W81XWH-09-1-0530 and W81XWH-09-1-0536 from Medical Research and Material Command of the Department of the Army. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 51 TC 14 Z9 15 U1 0 U2 6 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD JUL 6 PY 2012 VL 7 IS 7 AR e39934 DI 10.1371/journal.pone.0039934 PG 11 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 974UB UT WOS:000306461800026 PM 22792197 ER PT J AU Silva, LP Vanzile, M Bavari, S Aman, JMJ Schriemer, DC AF Silva, Leslie P. Vanzile, Michael Bavari, Sina Aman, J. M. Javad Schriemer, David C. TI Assembly of Ebola Virus Matrix Protein VP40 Is Regulated by Latch-Like Properties of N and C Terminal Tails SO PLOS ONE LA English DT Article ID POSTEXPOSURE PROTECTION; BINDING PROPERTIES; NONHUMAN-PRIMATES; RNA; PARTICLES; OLIGOMERIZATION; TRANSCRIPTION; GLYCOPROTEIN; ASSOCIATION; CHALLENGE AB The matrix protein VP40 coordinates numerous functions in the viral life cycle of the Ebola virus. These range from the regulation of viral transcription to morphogenesis, packaging and budding of mature virions. Similar to the matrix proteins of other nonsegmented, negative-strand RNA viruses, VP40 proceeds through intermediate states of assembly (e.g. octamers) but it remains unclear how these intermediates are coordinated with the various stages of the life cycle. In this study, we investigate the molecular basis of synchronization as governed by VP40. Hydrogen/deuterium exchange mass spectrometry was used to follow induced structural and conformational changes in VP40. Together with computational modeling, we demonstrate that both extreme N and C terminal tail regions stabilize the monomeric state through a direct association. The tails appear to function as a latch, released upon a specific molecular trigger such as RNA ligation. We propose that triggered release of the tails permits the coordination of late-stage events in the viral life cycle, at the inner membrane of the host cell. Specifically, N-tail release exposes the L-domain motifs PTAP/PPEY to the transport and budding complexes, whereas triggered C-tail release could improve association with the site of budding. C1 [Silva, Leslie P.; Schriemer, David C.] Univ Calgary, Dept Biochem & Mol Biol, Calgary, AB, Canada. [Vanzile, Michael; Bavari, Sina; Aman, J. M. Javad] USA, Med Res Inst Infect Dis, Frederick, MD USA. RP Silva, LP (reprint author), Univ Calgary, Dept Biochem & Mol Biol, Calgary, AB, Canada. EM dschriem@ucalgary.ca FU Alberta Innovates - Health Solutions; Defense Threat Reduction Agency [JSTO-CBD project] [44.10022-08-RD-B]; Defense Threat Reduction Agency TMTI (Transformational Medical Technologies Initiative) project [0048-09-RD-T] FX The work was supported in part by grants from Alberta Innovates - Health Solutions, the Defense Threat Reduction Agency [JSTO-CBD project 44.10022-08-RD-B and TMTI (Transformational Medical Technologies Initiative) project 0048-09-RD-T]. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 39 TC 7 Z9 7 U1 0 U2 13 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD JUL 5 PY 2012 VL 7 IS 7 AR e39978 DI 10.1371/journal.pone.0039978 PG 10 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 974LI UT WOS:000306436300018 PM 22792204 ER PT J AU Pollard, KA Blumstein, DT AF Pollard, Kimberly A. Blumstein, Daniel T. TI Evolving communicative complexity: insights from rodents and beyond SO PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES LA English DT Review DE sociality; individuality; repertoire size; alarm call; information theory; vocal complexity ID MARMOT ALARM CALLS; GROUND-SQUIRRELS SPERMOPHILUS; GROUP-SIZE; INDIVIDUAL RECOGNITION; ACOUSTIC STRUCTURE; SOCIAL COMPLEXITY; PRIMATE SOCIETIES; VOCAL COMPLEXITY; EVOLUTION; PREDATOR AB Social living goes hand in hand with communication, but the details of this relationship are rarely simple. Complex communication may be described by attributes as diverse as a species' entire repertoire, signallers' individualistic signatures, or complex acoustic phenomena within single calls. Similarly, attributes of social complexity are diverse and may include group size, social role diversity, or networks of interactions and relationships. How these different attributes of social and communicative complexity co-evolve is an active question in behavioural ecology. Sciurid rodents ( ground squirrels, prairie dogs and marmots) provide an excellent model system for studying these questions. Sciurid studies have found that demographic role complexity predicts alarm call repertoire size, while social group size predicts alarm call individuality. Along with other taxa, sciurids reveal an important insight: different attributes of sociality are linked to different attributes of communication. By breaking social and communicative complexity down to different attributes, focused studies can better untangle the underlying evolutionary relationships and move us closer to a comprehensive theory of how sociality and communication evolve. C1 [Pollard, Kimberly A.; Blumstein, Daniel T.] Univ Calif Los Angeles, Dept Ecol & Evolutionary Biol, Los Angeles, CA 90095 USA. [Pollard, Kimberly A.] USA, Human Res & Engn Directorate, Perceptual Sci Branch, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Pollard, KA (reprint author), Univ Calif Los Angeles, Dept Ecol & Evolutionary Biol, Los Angeles, CA 90095 USA. EM kpollard@ucla.edu OI Blumstein, Daniel/0000-0001-5793-9244 FU American Philosophical Society; American Society of Mammalogists; Animal Behavior Society; Explorers Club; Mildred Mathias/UC Reserves; National Geographic Society; National Institute of Health; National Science Foundation; Rocky Mountain Biological Laboratory; Sigma Xi; UCLA; UC Davis; University of Kansas FX We thank Todd Freeberg, Indrikis Krams and Cecilia Kullberg for organizing the ABS/IEC 2011 symposium on social complexity and communicative complexity and two anonymous reviewers for comments on a previous version of this manuscript. We thank our field collaborators and colleagues-Ken Armitage, Abigail Benson, Dean Biggins, Suzanne Cox-Griffin, David Eads, Chris Evans, Greg Grether, Jim Hare, John Hoogland, Marta Manser, Jill Mateo, Peter Nonacs, Don Owings, Dan Salkeld and Joan Silk-for access to animals and insightful comments over the years. For funding, we thank the American Philosophical Society, American Society of Mammalogists, Animal Behavior Society, Explorers Club, Mildred Mathias/UC Reserves, National Geographic Society, National Institute of Health, National Science Foundation, Rocky Mountain Biological Laboratory, Sigma Xi, UCLA, UC Davis and the University of Kansas. We also thank the many wonderful lab and field assistants who have helped both of us study the evolution of complex sociality and communication. NR 93 TC 31 Z9 31 U1 2 U2 74 PU ROYAL SOC PI LONDON PA 6-9 CARLTON HOUSE TERRACE, LONDON SW1Y 5AG, ENGLAND SN 0962-8436 EI 1471-2970 J9 PHILOS T R SOC B JI Philos. Trans. R. Soc. B-Biol. Sci. PD JUL 5 PY 2012 VL 367 IS 1597 SI SI BP 1869 EP 1878 DI 10.1098/rstb.2011.0221 PG 10 WC Biology SC Life Sciences & Biomedicine - Other Topics GA 948XS UT WOS:000304537700009 PM 22641825 ER PT J AU Chauncey, KM Lopez, MC Sidhu, G Szarowicz, SE Baker, HV Quinn, C Southwick, FS AF Chauncey, Kassidy M. Lopez, M. Cecilia Sidhu, Gurjit Szarowicz, Sarah E. Baker, Henry V. Quinn, Conrad Southwick, Frederick S. TI Bacillus anthracis' lethal toxin induces broad transcriptional responses in human peripheral monocytes SO BMC IMMUNOLOGY LA English DT Article ID DENDRITIC CELLS; INHALATIONAL ANTHRAX; MACROPHAGES; EXPRESSION; DIFFERENTIATION; SUSCEPTIBILITY; COMPONENTS; INCREASES; INFECTION; PATHOLOGY AB Background: Anthrax lethal toxin (LT), produced by the Gram-positive bacterium Bacillus anthracis, is a highly effective zinc dependent metalloprotease that cleaves the N-terminus of mitogen-activated protein kinase kinases (MAPKK or MEKs) and is known to play a role in impairing the host immune system during an inhalation anthrax infection. Here, we present the transcriptional responses of LT treated human monocytes in order to further elucidate the mechanisms of LT inhibition on the host immune system. Results: Western Blot analysis demonstrated cleavage of endogenous MEK1 and MEK3 when human monocytes were treated with 500 ng/mL LT for four hours, proving their susceptibility to anthrax lethal toxin. Furthermore, staining with annexin V and propidium iodide revealed that LT treatment did not induce human peripheral monocyte apoptosis or necrosis. Using Affymetrix Human Genome U133 Plus 2.0 Arrays, we identified over 820 probe sets differentially regulated after LT treatment at the p <0.001 significance level, interrupting the normal transduction of over 60 known pathways. As expected, the MAPKK signaling pathway was most drastically affected by LT, but numerous genes outside the well-recognized pathways were also influenced by LT including the IL-18 signaling pathway, Toll-like receptor pathway and the IFN alpha signaling pathway. Multiple genes involved in actin regulation, signal transduction, transcriptional regulation and cytokine signaling were identified after treatment with anthrax LT. Conclusion: We conclude LT directly targets human peripheral monocytes and causes multiple aberrant gene responses that would be expected to be associated with defects in human monocyte's normal signaling transduction pathways and function. This study provides further insights into the mechanisms associated with the host immune system collapse during an anthrax infection, and suggests that anthrax LT may have additional downstream targets outside the well-known MAPK pathway. C1 [Chauncey, Kassidy M.; Sidhu, Gurjit; Szarowicz, Sarah E.; Southwick, Frederick S.] Univ Florida, Coll Med, Dept Med, Gainesville, FL 32610 USA. [Lopez, M. Cecilia; Baker, Henry V.] Univ Florida, Dept Mol Genet & Microbiol, USA, Gainesville, FL 32610 USA. [Quinn, Conrad] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. RP Southwick, FS (reprint author), Univ Florida, Coll Med, Dept Med, Gainesville, FL 32610 USA. EM southfs@medicine.ufl.edu OI Baker, Henry/0000-0002-8273-5320 FU National Institutes of Health [RO1AI064891]; University of Florida Open-Access Publishing Fund FX We thank Dr. Lyle Moldawer for his guidance and assistance in the flow cytometry analysis. The study was supported by the National Institutes of Health RO1AI064891. Publication of this article was funded in part by the University of Florida Open-Access Publishing Fund. NR 33 TC 2 Z9 3 U1 0 U2 8 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1471-2172 J9 BMC IMMUNOL JI BMC Immunol. PD JUL 2 PY 2012 VL 13 AR 33 DI 10.1186/1471-2172-13-33 PG 26 WC Immunology SC Immunology GA 024UE UT WOS:000310133700001 PM 22747600 ER PT J AU Capretti, A Walsh, GF Minissale, S Trevino, J Forestiere, C Miano, G Dal Negro, L AF Capretti, Antonio Walsh, Gary F. Minissale, Salvatore Trevino, Jacob Forestiere, Carlo Miano, Giovanni Dal Negro, Luca TI Multipolar second harmonic generation from planar arrays of Au nanoparticles SO OPTICS EXPRESS LA English DT Article ID METAL NANOPARTICLES; SURFACE; SCATTERING; MODES; GOLD; RESONANCES; SPIRALS; LIGHT AB We demonstrate optical Second Harmonic Generation (SHG) in planar arrays of cylindrical Au nanoparticles arranged in periodic and deterministic aperiodic geometries. In order to understand the respective roles of near-field plasmonic coupling and long-range photonic interactions on the SHG signal, we systematically vary the interparticle separation from 60 nm to distances comparable to the incident pump wavelength. Using polarization-resolved measurements under femtosecond pumping, we demonstrate multipolar SHG signal largely tunable by the array geometry. Moreover, we show that the SHG signal intensity is maximized by arranging Au nanoparticles in aperiodic spiral arrays. The possibility to engineer multipolar SHG in planar arrays of metallic nanoparticles paves the way to the development of novel optical elements for nanophotonics, such as nonlinear optical sensors, compact frequency converters, optical mixers, and broadband harmonic generators on a chip. (C) 2012 Optical Society of America C1 [Capretti, Antonio; Walsh, Gary F.; Minissale, Salvatore; Trevino, Jacob; Forestiere, Carlo; Dal Negro, Luca] Boston Univ, Dept Elect & Comp Engn, Boston, MA 02215 USA. [Capretti, Antonio; Walsh, Gary F.; Minissale, Salvatore; Trevino, Jacob; Forestiere, Carlo; Dal Negro, Luca] Boston Univ, Photon Ctr, Boston, MA 02215 USA. [Capretti, Antonio; Miano, Giovanni] Univ Naples Federico II, Dept Elect Engn, I-80125 Naples, Italy. [Capretti, Antonio] CNR SPIN, I-80126 Naples, Italy. [Walsh, Gary F.] USA, NSRDEC, Nanomat Sci Team, Natick, MA 01760 USA. [Trevino, Jacob; Dal Negro, Luca] Boston Univ, Div Mat Sci & Engn, Brookline, MA 02446 USA. RP Capretti, A (reprint author), Boston Univ, Dept Elect & Comp Engn, 8 St Marys St, Boston, MA 02215 USA. EM dalnegro@bu.edu RI Forestiere, Carlo/A-7986-2013; Miano, Giovanni/L-3507-2014; Forestiere, Carlo/L-7754-2015; Capretti, Antonio/D-9948-2014; OI Miano, Giovanni/0000-0002-5765-799X; Forestiere, Carlo/0000-0003-2849-2513; Capretti, Antonio/0000-0002-6705-9280; Trevino, Jacob/0000-0002-7656-4107 FU Air Force program "Deterministic Aperiodic Structures for On-chip Nanophotonic and Nanoplasmonic Device Applications" [FA9550-10-1-0019]; U.S. Army Natick Soldier Center; SMART Scholarship Program FX This work was supported by the Air Force program "Deterministic Aperiodic Structures for On-chip Nanophotonic and Nanoplasmonic Device Applications" under Award FA9550-10-1-0019, the U.S. Army Natick Soldier Center, and the SMART Scholarship Program. This document has been approved for public release. NSRDEC PAO # U12-184. NR 37 TC 23 Z9 23 U1 4 U2 44 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1094-4087 J9 OPT EXPRESS JI Opt. Express PD JUL 2 PY 2012 VL 20 IS 14 BP 15797 EP 15806 DI 10.1364/OE.20.015797 PG 10 WC Optics SC Optics GA 971BF UT WOS:000306176100111 PM 22772269 ER PT J AU White, JO Vasilyev, A Cahill, JP Satyan, N Okusaga, O Rakuljic, G Mungan, CE Yariv, A AF White, J. O. Vasilyev, A. Cahill, J. P. Satyan, N. Okusaga, O. Rakuljic, G. Mungan, C. E. Yariv, A. TI Suppression of stimulated Brillouin scattering in optical fibers using a linearly chirped diode laser SO OPTICS EXPRESS LA English DT Article ID PHASE-LOCK LOOPS; COHERENT POWER COMBINATION; AMPLIFIER; GAIN AB The output of high power fiber amplifiers is typically limited by stimulated Brillouin scattering (SBS). An analysis of SBS with a chirped pump laser indicates that a chirp of 2.5 x 10(15) Hz/s could raise, by an order of magnitude, the SBS threshold of a 20-m fiber. A diode laser with a constant output power and a linear chirp of 5 x 10(15) Hz/s has been previously demonstrated. In a low-power proof-of-concept experiment, the threshold for SBS in a 6-km fiber is increased by a factor of 100 with a chirp of 5 x 10(14) Hz/s. A linear chirp will enable straightforward coherent combination of multiple fiber amplifiers, with electronic compensation of path length differences on the order of 0.2 m. (C) 2012 Optical Society of America C1 [White, J. O.; Cahill, J. P.; Okusaga, O.] USA, Res Lab, Adelphi, MD 20783 USA. [Vasilyev, A.; Satyan, N.; Yariv, A.] CALTECH, Dept Appl Phys & Mat Sci, Pasadena, CA 91125 USA. [Rakuljic, G.] Telaris Inc, Santa Monica, CA 90403 USA. [Mungan, C. E.] USN Acad, Dept Phys, Annapolis, MD 21402 USA. RP White, JO (reprint author), USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM jeffrey.owen.white@us.army.mil FU High Energy Laser Joint Technology Office [11-SA-0405] FX This work has been supported by High Energy Laser Joint Technology Office contract 11-SA-0405. We are also grateful for continuing technical input from Scott Christensen, John Edgecumbe, and Imtiaz Majid at Nufern. NR 24 TC 14 Z9 15 U1 2 U2 14 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1094-4087 J9 OPT EXPRESS JI Opt. Express PD JUL 2 PY 2012 VL 20 IS 14 BP 15872 EP 15881 DI 10.1364/OE.20.015872 PG 10 WC Optics SC Optics GA 971BF UT WOS:000306176100119 PM 22772277 ER PT J AU Schauffert, EA Cusatis, G Pelessone, D O'Daniel, JL Baylot, JT AF Schauffert, Edward A. Cusatis, Gianluca Pelessone, Daniele O'Daniel, James L. Baylot, James T. TI Lattice Discrete Particle Model for Fiber-Reinforced Concrete. II: Tensile Fracture and Multiaxial Loading Behavior SO JOURNAL OF ENGINEERING MECHANICS-ASCE LA English DT Article DE Concrete; Fiber reinforcing; Numerical models; Simulation; Lattice models; Particle models; Calibration; Validation; Fiber pull-out; Fiber debonding ID BOND-SLIP MECHANISMS; CEMENTITIOUS COMPOSITES; STEEL FIBERS; INCLINATION ANGLE; PULL-OUT; COMPRESSION; STRENGTH; MATRIX AB In Part I of this two-part study, a theory is provided for the extension of the lattice discrete particle model (LDPM) to include fiber reinforcing capability. The resulting model, LDPM-F, is calibrated and validated in the present paper by comparing numerical simulations with experimental data gathered from the literature. The analyzed experiments include direct tension, confined and unconfined compression, and notched three-point bending tests. DOI: 10.1061/(ASCE)EM.1943-7889.0000392. (C) 2012 American Society of Civil Engineers. C1 [Cusatis, Gianluca] Northwestern Univ, Evanston, IL 60208 USA. [Schauffert, Edward A.] Rensselaer Polytech Inst, Troy, NY 12180 USA. [Pelessone, Daniele] Engn & Software Syst Solut Inc ES3, San Diego, CA 92101 USA. [O'Daniel, James L.; Baylot, James T.] USA, ERDC, Vicksburg, MS 39180 USA. RP Cusatis, G (reprint author), Northwestern Univ, 1245 Sheridan Rd, Evanston, IL 60208 USA. EM schaue@rpi.edu; g-cusatis@northwestern.edu; daniele.pelessone@es3inc.com; james.l.o'daniel@usace.army.mil; james.t.baylot@usace.army.mil RI Cusatis, Gianluca/G-2539-2011 FU U.S. Army Engineer Research and Development Center; NSF [0928448]; DTRA [HDTRA1-09-1-0029] FX This effort was sponsored by the U.S. Army Engineer Research and Development Center. Permission to publish was granted by the Director, Geotechnical and Structures Laboratory. The work of G. C. was also supported under NSF Grant No. 0928448 and DTRA Grant No. HDTRA1-09-1-0029 to Rensselaer Polytechnic Institute. In addition, the writers wish to acknowledge the help of Mr. Marco Stacchini for performing the three-point bending simulations and of Professor Marco Savoia for providing the three-point bending experimental data. NR 32 TC 17 Z9 17 U1 7 U2 23 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 0733-9399 J9 J ENG MECH-ASCE JI J. Eng. Mech.-ASCE PD JUL PY 2012 VL 138 IS 7 BP 834 EP 841 DI 10.1061/(ASCE)EM.1943-7889.0000392 PG 8 WC Engineering, Mechanical SC Engineering GA 059HQ UT WOS:000312695400011 ER PT J AU Jepsen, RA Roberts, JD Kearney, SP Dimiduk, TG O'Hern, TJ Gailani, JZ AF Jepsen, Richard A. Roberts, Jesse D. Kearney, Sean P. Dimiduk, Thomas G. O'Hern, Timothy J. Gailani, Joseph Z. TI Shear Stress Measurements and Erosion Implications for Wave and Combined Wave-Current Generated Flows SO JOURNAL OF WATERWAY PORT COASTAL AND OCEAN ENGINEERING-ASCE LA English DT Article DE Waves; Sediment; PIV; Erosion; Oscillation; Laminar; Turbulent ID BOUNDARY-LAYERS; BULK-DENSITY; TURBULENCE; BOTTOM AB Sediment transport in wave-dominated environments is of great interest for dredged material placement, contaminated sediments, habitat protection, and other issues. The shear stress at the sediment-water interface during a wave event is an important parameter in determining erosion and transport for both experimental and model simulation applications. Sandia National Laboratories has developed a laboratory and field device called the sediment erosion actuated by wave oscillations and linear flow (SEAWOLF) flume in which high-resolution, particle-image velocimetry (PIV) has been applied to investigate turbulent flow shear stresses for a variety of flow conditions. The results of the PIV analysis for a wave cycle demonstrate a fully developed turbulent flow, relaminarization, and an explosive transition back to turbulence. In many cases, the results of the flume tests did not show good agreement with previously reported computational fluid dynamic results and existing theories, such as Blasius, for wave-current interactions, which raises the question of whether similar phenomena are present in real environments. These results implore more studies to be conducted with similarly high-resolution field measurements and modeling efforts to determine shear stress time history for oscillatory flows and the subsequent effects on erosion and sediment transport in wave-dominated environments. DOI: 10.1061/(ASCE)WW.1943-5460.0000137. (C) 2012 American Society of Civil Engineers. C1 [Jepsen, Richard A.; Roberts, Jesse D.; Kearney, Sean P.; O'Hern, Timothy J.] Sandia Natl Labs, Albuquerque, NM 87185 USA. [Dimiduk, Thomas G.] Cornell Univ, Appl & Engn Phys Dept, Ithaca, NY 14853 USA. [Gailani, Joseph Z.] USA, Corps Engineers, Engn Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Jepsen, RA (reprint author), Sandia Natl Labs, POB 5800, Albuquerque, NM 87185 USA. EM rajepse@sandia.gov FU Strategic Environmental Research and Development Program (SERDP); Environmental Security Technology Certification Program (ESTCP); United States Department of Energy's National Nuclear Security Administration [DE-AC04-94AL85000] FX The writers thank Janet Barco for her technical review of the text and editing of the figures for the final manuscript. This work was funded by the Strategic Environmental Research and Development Program (SERDP) and the Environmental Security Technology Certification Program (ESTCP). SERDP is the Department of Defense's (DoD) environmental science and technology program, planned and executed in full partnership with the Department of Energy and the Environmental Protection Agency, with participation by numerous other federal and nonfederal organizations. ESTCP is a DoD program that promotes innovative, cost-effective environmental technologies through demonstration and validation at DoD sites. This work was conducted at Sandia National Laboratories. Sandia is a multiprogram laboratory operated by Sandia Corporation, a Lockheed-Martin Company, for the United States Department of Energy's National Nuclear Security Administration under Contract DE-AC04-94AL85000. NR 17 TC 0 Z9 1 U1 3 U2 11 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 0733-950X J9 J WATERW PORT C-ASCE JI J. Waterw. Port Coast. Ocean Eng.-ASCE PD JUL PY 2012 VL 138 IS 4 BP 323 EP 329 DI 10.1061/(ASCE)WW.1943-5460.0000137 PG 7 WC Engineering, Civil; Engineering, Ocean; Water Resources SC Engineering; Water Resources GA 064AD UT WOS:000313042400006 ER PT J AU Nitayaphan, S Ngauy, V O'Connell, R Excler, JL AF Nitayaphan, Sorachai Ngauy, Viseth O'Connell, Robert Excler, Jean-Louis TI HIV epidemic in Asia: optimizing and expanding vaccine development SO EXPERT REVIEW OF VACCINES LA English DT Review DE Asia; efficacy trial; HIV; prime-boost; vaccine ID HUMAN-IMMUNODEFICIENCY-VIRUS; SEXUALLY-TRANSMITTED INFECTIONS; INJECTION-DRUG USERS; PHASE-I TRIAL; INTERNATIONAL CLINICAL-TRIALS; SYNTHETIC PEPTIDE VACCINE; RESEARCH-AND-DEVELOPMENT; MIDDLE-INCOME COUNTRIES; FULL-LENGTH GENOMES; MALE SEX WORKERS AB The recent evidence in Thailand for protection from acquisition of HIV through vaccination in a mostly heterosexual population has generated considerable hope. Building upon these results and the analysis of the correlates of risk remains among the highest priorities. Improved vaccine concepts including heterologous prime boost regimens, improved proteins with potent adjuvants and new vectors expressing mosaic antigens may soon enter clinical development to assess vaccine efficacy in men who have sex with men. Identifying heterosexual populations with sufficient HIV incidence for the conduct of efficacy trials represents perhaps the main challenge in Asia. Fostering translational research efforts in Asian countries may benefit from the development of master strategic plans and program management processes. C1 [O'Connell, Robert; Excler, Jean-Louis] Henry M Jackson Fdn Adv Mil Med, US Mil HIV Res Program MHRP, Bethesda, MD 20817 USA. [Nitayaphan, Sorachai] Royal Thai Army Component, AFRIMS, Bangkok 10400, Thailand. [Ngauy, Viseth] US Army Med Component, Armed Forces Res Inst Med Sci, Dept Retrovirol, US Mil HIV Res Program MHRP, Bangkok 10400, Thailand. RP Excler, JL (reprint author), Henry M Jackson Fdn Adv Mil Med, US Mil HIV Res Program MHRP, 6720-A Rockledge Dr,Suite 400, Bethesda, MD 20817 USA. EM jexcler@hivresearch.org FU US Army Medical Research and Material Command (USAMRMC); Henry M Jackson Foundation for the Advancement of Military Medicine [DAMD17-98-2-7007] FX The authors have received finding from the US Army Medical Research and Material Command (USAMRMC), and its Cooperative Agreement (DAMD17-98-2-7007) with the Henry M Jackson Foundation for the Advancement of Military Medicine. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. NR 164 TC 7 Z9 7 U1 3 U2 13 PU EXPERT REVIEWS PI LONDON PA UNITEC HOUSE, 3RD FL, 2 ALBERT PLACE, FINCHLEY CENTRAL, LONDON N3 1QB, ENGLAND SN 1476-0584 J9 EXPERT REV VACCINES JI Expert Rev. Vaccines PD JUL PY 2012 VL 11 IS 7 BP 805 EP 819 DI 10.1586/ERV.12.49 PG 15 WC Immunology SC Immunology GA 028GW UT WOS:000310411800015 PM 22913258 ER PT J AU Sparvero, LJ Amoscato, AA Dixon, CE Long, JB Kochanek, PM Pitt, BR Bayir, H Kagan, VE AF Sparvero, Louis J. Amoscato, Andrew A. Dixon, C. Edward Long, Joseph B. Kochanek, Patrick M. Pitt, Bruce R. Bayir, Huelya Kagan, Valerian E. TI Mapping of phospholipids by MALDI imaging (MALDI-MSI): realities and expectations SO CHEMISTRY AND PHYSICS OF LIPIDS LA English DT Article DE Lipidomics; MALDI imaging; Traumatic brain injury; Acute lung injury; Lipid peroxidation; Docosahexaenoic acid ID TRAUMATIC BRAIN-INJURY; LASER-DESORPTION-IONIZATION; HIGH-SPATIAL-RESOLUTION; MASS-SPECTROMETRIC CHARACTERIZATION; ION MOBILITY-TOFMS; OXIDATIVE LIPIDOMICS; ELECTROSPRAY-IONIZATION; STRUCTURAL-CHARACTERIZATION; SHOTGUN LIPIDOMICS; MATRIX DEPOSITION AB Matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) has emerged as a novel powerful MS methodology that has the ability to generate both molecular and spatial information within a tissue section. Application of this technology as a new type of biochemical lipid microscopy may lead to new discoveries of the lipid metabolism and biomarkers associated with area-specific alterations or damage under stress/disease conditions such as traumatic brain injury or acute lung injury, among others. However there are limitations in the range of what it can detect as compared with liquid chromatography-MS (LC-MS) of a lipid extract from a tissue section. The goal of the current work was to critically consider remarkable new opportunities along with the limitations and approaches for further improvements of MALDI-MSI. Based on our experimental data and assessments, improvements of the spectral and spatial resolution, sensitivity and specificity towards low abundance species of lipids are proposed. This is followed by a review of the current literature, including methodologies that other laboratories have used to overcome these challenges. (C) 2012 Elsevier Ireland Ltd. All rights reserved. C1 [Sparvero, Louis J.; Amoscato, Andrew A.; Bayir, Huelya; Kagan, Valerian E.] Ctr Free Rad & Antioxidant Hlth, Pittsburgh, PA 15213 USA. [Dixon, C. Edward; Kochanek, Patrick M.; Bayir, Huelya] Safar Ctr Resuscitat Res, Pittsburgh, PA 15213 USA. [Sparvero, Louis J.; Amoscato, Andrew A.; Pitt, Bruce R.; Bayir, Huelya; Kagan, Valerian E.] Dept Environm & Occupat Hlth, Pittsburgh, PA 15213 USA. [Kochanek, Patrick M.; Bayir, Huelya] Dept Crit Care Med, Pittsburgh, PA 15213 USA. [Dixon, C. Edward] Univ Pittsburgh, Dept Neurosurg, Pittsburgh, PA 15213 USA. [Long, Joseph B.] Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci, Silver Spring, MD 21910 USA. RP Sparvero, LJ (reprint author), Univ Pittsburgh, Dept Environm & Occupat Hlth, Ctr Free Rad & Antioxidant Hlth, 100 Technol Dr,Suite 350, Pittsburgh, PA 15219 USA. EM ljs39@pitt.edu; amoscatoaa@upmc.edu; dixoec@upmc.edu; joseph.long@us.army.mil; kochanekpm@ccm.upmc.edu; brucep@pitt.edu; bayihx@ccm.upmc.edu; kagan@pitt.edu RI Kochanek, Patrick/D-2371-2015; OI Kochanek, Patrick/0000-0002-2627-913X; Amoscato, Andrew/0000-0002-1340-9150 FU NIH [U19AI068021, HL70755, HL094488, ES020693, ES021068, NS076511]; Cancer Center Support Grant (CCSG) [P30 CA047904]; NIOSH [OH008282]; US Army [W81XWH-09-2-0187] FX This study was supported in part by grants from NIH (U19AI068021, HL70755, HL094488, ES020693, ES021068, and NS076511); Cancer Center Support Grant (CCSG) P30 CA047904; NIOSH (OH008282) and the US Army (W81XWH-09-2-0187). NR 120 TC 41 Z9 42 U1 9 U2 72 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0009-3084 J9 CHEM PHYS LIPIDS JI Chem. Phys. Lipids PD JUL PY 2012 VL 165 IS 5 BP 545 EP 562 DI 10.1016/j.chemphyslip.2012.06.001 PG 18 WC Biochemistry & Molecular Biology; Biophysics SC Biochemistry & Molecular Biology; Biophysics GA 004KX UT WOS:000308681700006 PM 22692104 ER PT J AU Shubitidze, F Fernandez, JP Shamatava, I Barrowes, BE O'Neill, K AF Shubitidze, Fridon Fernandez, Juan Pablo Shamatava, Irma Barrowes, Benjamin E. O'Neill, Kevin TI Joint diagonalization applied to the detection and discrimination of unexploded ordnance SO GEOPHYSICS LA English DT Article ID ELECTROMAGNETIC INDUCTION SENSORS; BLIND SOURCE SEPARATION; IDENTIFICATION; SURFACE; MODEL AB Efforts to discriminate buried unexploded ordnance from harmless surrounding clutter are often hampered by the uncertainty in the number of buried targets that produce a given detected signal. We present a technique that helps determine that number with no need for data inversion. The procedure is based on the joint diagonalization of a set of multistatic response (MSR) matrices measured at different time gates by a time-domain electromagnetic induction sensor. In particular, we consider the Naval Research Laboratory's Time-Domain Electromagnetic Multisensor Towed Array Detection System (TEMTADS), which consists of a 5 x 5 square grid of concentric transmitter/receiver pairs. The diagonalization process itself generalizes one of the standard procedures for extracting the eigenvalues of a single matrix; in terms of execution time, it is comparable to diagonalizing the matrices one by one. We present the method, discuss and illustrate its mathematical basis and physical meaning, and apply it to several actual measurements carried out with TEMTADS at a test stand and in the field at the former Camp Butner in North Carolina. We find that each target in a measurement is associated with a set of nonzero time-dependent MSR eigenvalues (usually three), which enables estimation of the number of targets interrogated. These eigenvalues have a characteristic shape as a function of time that does not change with the location and orientation of the target relative to the sensor. We justify analytically and empirically that symmetric targets have pairs of eigenvalues with constant ratios between them. C1 [Shubitidze, Fridon; Shamatava, Irma; Barrowes, Benjamin E.; O'Neill, Kevin] Dartmouth Coll, Thayer Sch Engn, Hanover, NH 03755 USA. [Shubitidze, Fridon; Shamatava, Irma] Sky Res Inc, Etna, NH USA. [Barrowes, Benjamin E.; O'Neill, Kevin] USA, Corps Engineers, ERDC CRREL, Hanover, NH USA. RP Shubitidze, F (reprint author), Dartmouth Coll, Thayer Sch Engn, Hanover, NH 03755 USA. EM fridon.shubitidze@dartmouth.edu; jpf@alumni.umass.edu; irma.shamatava@dartmouth.edu; benjamin.e.barrowes@usace.army.mil; kevin.o'neill@usace.army.mil FU Strategic Environmental Research and Development Program (SERDP) [MR-1572, MR-1664]; Environmental Strategic Technology Certification Program [MR-201101] FX This work was supported by the Strategic Environmental Research and Development Program (SERDP) through Projects MR-1572 and MR-1664 and by the Environmental Strategic Technology Certification Program through Project MR-201101. The authors would like to thank Dan Steinhurst of Nova Research, Inc. for taking the test-stand data. NR 33 TC 11 Z9 11 U1 0 U2 5 PU SOC EXPLORATION GEOPHYSICISTS PI TULSA PA 8801 S YALE ST, TULSA, OK 74137 USA SN 0016-8033 J9 GEOPHYSICS JI Geophysics PD JUL-AUG PY 2012 VL 77 IS 4 SU S BP WB149 EP WB160 DI 10.1190/GEO2011-0387.1 PG 12 WC Geochemistry & Geophysics SC Geochemistry & Geophysics GA 992SH UT WOS:000307799500014 ER PT J AU Zifchock, RA Pratt, K Brown, A Hillstrom, H AF Zifchock, Rebecca Avrin Pratt, Kristamarie Brown, Allison Hillstrom, Howard TI Knee Kinematic Coupling in Males and Females: Open and Closed-Chain Tasks SO JOURNAL OF APPLIED BIOMECHANICS LA English DT Article DE knee coupling; gait; stair climbing ID ILIOTIBIAL BAND SYNDROME; GENDER-DIFFERENCES; RUNNERS; VARIABILITY; BIOMECHANICS; HISTORY AB The purpose of this study was to compare the magnitude of knee kinematic coupling between genders and among open- and closed-chain tasks. A secondary purpose was to compare the consistency of knee kinematic coupling between genders and among open- and closed-chain tasks. Vector-coding methods were used to quantify coupling in the sagittal and transverse planes of the knee between full extension and 20 degrees of flexion as 10 males and 10 females walked, ascended and descended stairs, and performed a passive pendulum leg drop. An ANOVA showed no main effect of gender. There was a main effect of task, where coupling during the stance phase of walking was significantly greater than each of the other tasks. Intraclass correlation values suggested that males were slightly more consistent than females. A general lack of divergence between genders may be related to the tasks analyzed in this study. It is possible that more strenuous tasks may elicit larger differences. C1 [Zifchock, Rebecca Avrin] US Mil Acad, Dept Civil & Mech Engn, West Point, NY 10996 USA. [Pratt, Kristamarie] Univ So Calif, Los Angeles, CA USA. [Brown, Allison] Univ Med & Dent New Jersey, Newark, NJ 07103 USA. [Hillstrom, Howard] Hosp Special Surg, Mot Anal Lab, New York, NY 10021 USA. RP Zifchock, RA (reprint author), US Mil Acad, Dept Civil & Mech Engn, West Point, NY 10996 USA. OI Pratt, Kristamarie/0000-0001-8422-4834 NR 19 TC 0 Z9 0 U1 0 U2 4 PU HUMAN KINETICS PUBL INC PI CHAMPAIGN PA 1607 N MARKET ST, PO BOX 5076, CHAMPAIGN, IL 61820-2200 USA SN 1065-8483 J9 J APPL BIOMECH JI J. Appl. Biomech. PD JUL PY 2012 VL 28 IS 3 BP 291 EP 296 PG 6 WC Engineering, Biomedical; Sport Sciences SC Engineering; Sport Sciences GA 998YZ UT WOS:000308277600008 ER PT J AU Gauer, R Qiu, KF Crawford, P AF Gauer, Robert Qiu, Kefeng (Maylene) Crawford, Paul TI Does blood pressure screening benefit children? SO JOURNAL OF FAMILY PRACTICE LA English DT Editorial Material ID ADOLESCENTS; RISK C1 [Gauer, Robert] Womack Army Med Ctr, Family Med Residency Clin, Ft Bragg, NC USA. [Qiu, Kefeng (Maylene)] Univ Penn, Biomed Lib, Philadelphia, PA 19104 USA. [Crawford, Paul] Nellis AFB Family Med Residency, Nellis Afb, NV USA. RP Gauer, R (reprint author), Womack Army Med Ctr, Family Med Residency Clin, Ft Bragg, NC USA. NR 9 TC 2 Z9 2 U1 0 U2 0 PU DOWDEN HEALTH MEDIA PI MONTVALE PA 110 SUMMIT AVE, MONTVALE, NJ 07645-1712 USA SN 0094-3509 J9 J FAM PRACTICE JI J. Fam. Pract. PD JUL PY 2012 VL 61 IS 7 BP 425 EP 426 PG 2 WC Primary Health Care; Medicine, General & Internal SC General & Internal Medicine GA 003MR UT WOS:000308616400009 PM 22754893 ER PT J AU Gupta, N Tan, SS Zander, DR AF Gupta, Neelam Tan, Songsheng Zander, Dennis R. TI Microelectromechanical systems-based visible-near infrared Fabry-Perot tunable filters using quartz substrate SO OPTICAL ENGINEERING LA English DT Article DE microelectromechanical systems; quartz substrate; Fabry-Perot tunable filter; visible near-infrared; electrostatic actuation ID MEMS AB There is a need to develop miniature optical tunable filters for small hyperspectral imagers. We plan to develop a number of miniature Fabry-Perot tunable filters (FPTFs) using microelectromechanical systems (MEMS) technology, each operating over a different wavelength region, to cover spectral regions from the visible to the longwave infrared (IR). Use of a MEMS-based FPTF as a dispersive element will reduce the size, weight, and power requirements of hyperspectral imagers and make them less expensive. A key requirement for such a filter is a large optical aperture. Recently, we succeeded in fabricating FPTFs with a 6 mm optical aperture operating in the visible to near IR spectral region (400 to 800 nm) using commercially available thin quartz wafers as the substrate. The FPTF design contains one fixed silver (Ag) mirror and one electrostatically movable Ag mirror, each grown on a quartz substrate with a low total thickness variation. Gold (Au) bumps are used to control the initial air gap distance between the two mirrors, and Au-Au bonding is used to bond the device. We describe material selection, device design, modeling, fabrication, interferometric, and spectral characterizations. (C) 2012 Society of Photo-Optical Instrumentation Engineers (SPIE). [DOI: 10.1117/1.OE.51.7.074007] C1 [Gupta, Neelam] USA, Res Lab, Adelphi, MD 20783 USA. [Tan, Songsheng] Smart Syst Technol & Commercializat Ctr, Canandaigua, NY 14424 USA. [Zander, Dennis R.] SpectralSight Inc, Rochester, NY 14624 USA. RP Gupta, N (reprint author), USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM neelam.gupta.civ@mail.mil RI Gupta, Neelam/B-8702-2013 NR 10 TC 2 Z9 2 U1 0 U2 13 PU SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98225 USA SN 0091-3286 J9 OPT ENG JI Opt. Eng. PD JUL PY 2012 VL 51 IS 7 AR 074007 DI 10.1117/1.OE.51.7.074007 PG 8 WC Optics SC Optics GA 000BJ UT WOS:000308361200032 ER PT J AU Owens, BD AF Owens, Brett D. TI Shoulder Instability in Athletes SO ORTHOPEDICS LA English DT Editorial Material ID EXTERNAL ROTATION; DISLOCATION; 1ST-TIME C1 Keller Army Community Hosp, Orthopaed Surg Serv, West Point, NY 10996 USA. RP Owens, BD (reprint author), Keller Army Community Hosp, Orthopaed Surg Serv, West Point, NY 10996 USA. EM b.owens@us.army.mil NR 6 TC 0 Z9 0 U1 0 U2 1 PU SLACK INC PI THOROFARE PA 6900 GROVE RD, THOROFARE, NJ 08086 USA SN 0147-7447 J9 ORTHOPEDICS JI Orthopedics PD JUL PY 2012 VL 35 IS 7 BP 593 EP 594 DI 10.3928/01477447-20120621-05 PG 2 WC Orthopedics SC Orthopedics GA 979QV UT WOS:000306835800033 PM 22784886 ER PT J AU Blank, E Owens, BD Burks, R Belmont, PJ AF Blank, Elizabeth Owens, Brett D. Burks, Robert Belmont, Philip J., Jr. TI Incidence of Greater Trochanteric Pain Syndrome in Active Duty US Military Servicemembers SO ORTHOPEDICS LA English DT Article ID ROTATOR CUFF TEARS; HIP PAIN; GLUTEUS MEDIUS; UNITED-STATES; BURSITIS; EPIDEMIOLOGY; OVERWEIGHT AB Although greater trochanteric pain syndrome is thought to be a common musculoskeletal disorder, little has been reported on the incidence rates of the disorder. The purpose of this study was to determine the incidence and demographic risk factors of greater trochanteric pain syndrome in a United States military population. Multivariate Poisson regression analysis was used to estimate the rate of greater trochanteric pain syndrome per 1000 person-years, controlling for sex, race, age, rank, and branch of service. The overall unadjusted incidence rate of greater trochanteric pain syndrome was 2.03 per 1000 person-years. Women had a significantly increased adjusted incidence rate ratio for greater trochanteric pain syndrome of 5.03 (95% confidence interval [CI], 4.91-5.16). The adjusted incidence rate ratio for White servicemembers compared with Black servicemembers was 1.36 (95% CI, 1.32-1.40). The adjusted incidence rate ratio for the 40+ age group compared with the 25 to 29 age group was 2.81 (95% CI, 2.68-2.95). Compared with junior officers, junior and senior enlisted ranks had an increased adjusted incidence rate ratio of 1.94 (95% CI, 1.84-2.04) and 1.17 (95% CI, 1.12-1.23), respectively. Compared with the Navy, each branch of service had an increased adjusted incidence rate ratio, with the Army at 2.90 (95% CI, 2.80-3.01), the Marines at 1.96 (95% CI, 1.87-2.07), and the Air Force at 1.33 (95% CI, 1.27-1.38). Female servicemembers had a five-fold greater incidence of greater trochanteric pain syndrome. Increasing age, enlisted rank groups, and service in the Army, Marines, or Air Force were also significant risk factors. C1 [Belmont, Philip J., Jr.] William Beaumont Army Med Ctr, Dept Orthopaed & Rehabil, El Paso, TX 79920 USA. [Blank, Elizabeth] Gen Leonard Wood Army Community Hosp, Orthopaed Surg Serv, Ft Leonard Wood, MO USA. [Owens, Brett D.] Keller Army Community Hosp, Orthopaed Surg Serv, West Point, NY USA. [Burks, Robert] USN, Postgrad Sch, Monterey, CA USA. RP Belmont, PJ (reprint author), William Beaumont Army Med Ctr, Dept Orthopaed & Rehabil, 5005 N Piedras St, El Paso, TX 79920 USA. EM philip.belmont@amedd.army.mil RI Burks, Robert/J-2481-2015; OI Burks, Robert/0000-0001-6443-6653; Belmont, Philip/0000-0003-2618-199X NR 28 TC 8 Z9 8 U1 0 U2 5 PU SLACK INC PI THOROFARE PA 6900 GROVE RD, THOROFARE, NJ 08086 USA SN 0147-7447 J9 ORTHOPEDICS JI Orthopedics PD JUL PY 2012 VL 35 IS 7 BP E1022 EP E1027 DI 10.3928/01477447-20120621-14 PG 6 WC Orthopedics SC Orthopedics GA 979QV UT WOS:000306835800003 PM 22784894 ER PT J AU Willer, RL Storey, RF Campbell, CG Bunte, SW Parrish, D AF Willer, Rodney L. Storey, Robson F. Campbell, Christopher G. Bunte, Steven W. Parrish, Damon TI A Re-Examination of the Reaction of 3,4-Diamino[1,2,5]oxadiazole with Glyoxal SO JOURNAL OF HETEROCYCLIC CHEMISTRY LA English DT Article ID THIN-FILM DEVICES; CHEMISTRY; FURAZANO<3,4-B>PIPERAZINE AB Reaction coordinate mapping was used to study the reaction of 3,4-diamino[1,2,5]oxadiazole (3,4-diaminofurazan) and 3,4-diamino[1,2,5]thiadiazole with glyoxal. The thiadiazole was known to give a good yield of [1,2,5]thiadiazolo[3,4-b]pyrazine, whereas the oxadiazole had not yielded, until now, [1,2,5]oxadiazolo[3,4-b]pyrazine (or furazano[2,3-b]pyrazine). The calculations suggested that the diols, 5,6-dihydroxy-4,5,6,7-tetrahydro[1,2,5]oxadiazolo[3,4-b]pyrazine and 5,6-dihydroxy-4,5,6,7-tetrahydro[1,2,5]thiadiazolo[3,4-b]pyrazine should be stable intermediates, and once formed, should provide a pathway to the target compounds via two dehydration steps, under forcing conditions. With this information in mind, the reactions of 3,4-diamino[1,2,5]oxadiazole with glyoxal and pyruvic aldehyde were re-examined. The reaction of 3,4-diamino[1,2,5]oxadiazole with glyoxal and pyruvic aldehyde produced, under slightly basic conditions, a near quantitative yield of the expected initial products, 5,6-dihydroxy-4,5,6,7-tetrahydro[1,2,5]oxadiazolo[3,4-b]pyrazine and the 5-methyl analog, respectively. The diols were easily isolated by lyophilizing the aqueous reaction mixture. The diols were pyrolized on silica gel at 160 degrees C to give the desired [1,2,5]oxadiazolo[3,4-b]pyrazine and the 5-methyl analog. Both compounds were easily reduced to the corresponding 4,5,6,7-tetrahydro-derivative using sodium borohydride in THF/methanol. The [1,2,5]oxadiazolo[3,4-b]pyrazine also displayed other interesting chemistry. C1 [Willer, Rodney L.; Storey, Robson F.; Campbell, Christopher G.] Univ So Mississippi, Sch Polymers & High Performance Mat, Hattiesburg, MS 39406 USA. [Bunte, Steven W.] USA, Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. [Parrish, Damon] USN, Res Lab, Washington, DC 20375 USA. RP Willer, RL (reprint author), Univ So Mississippi, Sch Polymers & High Performance Mat, Hattiesburg, MS 39406 USA. EM rodney.willer@usm.edu FU Office of Naval Research [N00014-081006, N00014-11-AF-0-0002, N0001411MP20002] FX This work was funded by grants N00014-081006 (USM), N00014-11-AF-0-0002 (NRL), and N0001411MP20002 (ARL) from the Office of Naval Research (Dr. Clifford Bedford). The 3,4-diamino[1,2,5]oxadiazole used was kindly supplied by Dr. Stephen Palopoli and Robert Day of Alliant Tech Systems-Elkton, MD. All calculations were performed at the ARL DoD Supercomputing Resource Center of the Department of Defense High Performance Computing Modernization Program. NR 20 TC 1 Z9 1 U1 1 U2 14 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0022-152X EI 1943-5193 J9 J HETEROCYCLIC CHEM JI J. Heterocycl. Chem. PD JUL PY 2012 VL 49 IS 4 BP 919 EP 925 DI 10.1002/jhet.1054 PG 7 WC Chemistry, Organic SC Chemistry GA 003CX UT WOS:000308586900034 ER PT J AU Gupta, N Tan, SS AF Gupta, Neelam Tan, Songsheng TI Spectral imaging characterization of quartz MOEM tunable Fabry-Perot filter SO JOURNAL OF MICRO-NANOLITHOGRAPHY MEMS AND MOEMS LA English DT Article DE MOEM; Fabry-Perot; tunable filter; quartz; electrostatic actuation; visible near-IR; spectral imaging; acousto-optic tunable filter AB Recently, prototype MOEM tunable Fabry-Perot filters operating from 400 to 800 nm were fabricated under a program to design miniature hyperspectral imagers operating from the visible to the longwave infrared. The filter design uses two semitransparent 30 nm thick silver-film mirrors, one fixed and the other moving, on a low-cost thin commercial quartz substrate. The moving mirror is supported by three leaf spring arms, which are fabricated by wet etching of the quartz substrate. The tuning of the transmitted wavelength of light from the filter is achieved by electrostatically actuating the moving mirror to vary the distance between the two mirrors. The size of the device is 18 x 24 mm(2). The fixed part has a 6 mm diameter mirror and three electrodes to apply voltages, and the moving mirror is used as a ground electrode. Au bumps deposited on both parts control the initial air gap distance, and an Au-Au bonding is used to bond the two parts together. The spectral imaging performance of the MOEM filter is characterized using a spectrally tunable source and a CCD camera with suitable optics. The authors present a brief description of the filter, its characteristics, spectral imaging characterization experiment and results. (C) 2012 Society of Photo-Optical Instrumentation Engineers (SPIE). [DOI: 10.1117/1.JMM.11.3.033002] C1 [Gupta, Neelam] USA, Res Lab, Adelphi, MD 20783 USA. [Tan, Songsheng] Smart Syst Technol & Commercializat Ctr, New York, NY 14424 USA. RP Gupta, N (reprint author), USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM neelam.gupta.civ@mail.mil RI Gupta, Neelam/B-8702-2013 NR 10 TC 1 Z9 1 U1 0 U2 11 PU SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98225 USA SN 1932-5150 J9 J MICRO-NANOLITH MEM JI J. Micro-Nanolithogr. MEMS MOEMS PD JUL-SEP PY 2012 VL 11 IS 3 AR 033002 DI 10.1117/1.JMM.11.3.033002 PG 6 WC Engineering, Electrical & Electronic; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Optics SC Engineering; Science & Technology - Other Topics; Materials Science; Optics GA 000OD UT WOS:000308394800015 ER PT J AU Valente, D Ronsse, LM Pater, L White, MJ Serwy, R Nykaza, ET Swearingen, ME Albert, DG AF Valente, Dan Ronsse, Lauren M. Pater, Larry White, Michael J. Serwy, Roger Nykaza, Edward T. Swearingen, Michelle E. Albert, Donald G. TI Blast noise characteristics as a function of distance for temperate and desert climates SO JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA LA English DT Article DE acoustic noise; acoustic variables measurement; acoustic wave propagation ID SOUND-PROPAGATION; STATISTICAL DESCRIPTION; BOUNDARY-LAYER; ATMOSPHERE AB Variability in received sound levels were investigated at distances ranging from 4 m to 16 km from a typical blast source in two locations with different climates and terrain. Four experiments were conducted, two in a temperate climate with a hilly terrain and two in a desert climate with a flat terrain, under a variety of meteorological conditions. Sound levels were recorded in three different directions around the source during the summer and winter seasons in each location. Testing occurred over the course of several days for each experiment during all 24 h of the day, and meteorological data were gathered throughout each experiment. The peak levels (L-Pk), C-weighted sound exposure levels (CSEL), and spectral characteristics of the received sound pressure levels were analyzed. The results show high variability in L-Pk and CSEL at distances beyond 2 km from the source for each experiment, which was not clearly explained by the time of day the blasts occurred. Also, as expected, higher frequency energy is attenuated more drastically than the lower frequency energy as the distance from the source increases. These data serve as a reference for long-distance blast sound propagation. [http://dx.doi.org/10.1121/1.4728171] C1 [Valente, Dan; Ronsse, Lauren M.; Pater, Larry; White, Michael J.; Serwy, Roger; Nykaza, Edward T.; Swearingen, Michelle E.] USA, Corps Engineers, Engineer Res & Dev Ctr, Construct Engn Res Lab, Champaign, IL 61826 USA. [Albert, Donald G.] USA, Corps Engineers, Engineer Res & Dev Ctr, Cold Reg Res Lab, Hanover, NH 03755 USA. RP Valente, D (reprint author), USA, Corps Engineers, Engineer Res & Dev Ctr, Construct Engn Res Lab, POB 9005, Champaign, IL 61826 USA. EM daniel.p.valente@usace.army.mil RI White, Michael/B-3612-2009 OI White, Michael/0000-0001-8450-9135 NR 25 TC 2 Z9 2 U1 1 U2 4 PU ACOUSTICAL SOC AMER AMER INST PHYSICS PI MELVILLE PA STE 1 NO 1, 2 HUNTINGTON QUADRANGLE, MELVILLE, NY 11747-4502 USA SN 0001-4966 J9 J ACOUST SOC AM JI J. Acoust. Soc. Am. PD JUL PY 2012 VL 132 IS 1 BP 216 EP 227 DI 10.1121/1.4728171 PG 12 WC Acoustics; Audiology & Speech-Language Pathology SC Acoustics; Audiology & Speech-Language Pathology GA 973LS UT WOS:000306362200032 PM 22779471 ER PT J AU Nakamura-Messenger, K Herzog, GF Smith, T Keller, LP Flynn, GJ Khodja, H Taylor, S Wirick, S Messenger, S AF Nakamura-Messenger, K. Herzog, G. F. Smith, T. Keller, L. P. Flynn, G. J. Khodja, H. Taylor, S. Wirick, S. Messenger, S. TI COORDINATED ANALYSES OF MINERAL-ORGANIC MATTER ASSOCIATIONS IN INTERPLANETARY DUST PARTICLES SO METEORITICS & PLANETARY SCIENCE LA English DT Meeting Abstract CT 75th Annual Meeting of the Meteoritical-Society CY AUG 12-17, 2012 CL Cairns, AUSTRALIA SP Meteorit Soc, Australian Natl Univ, Australian Sci Instruments, Barringer Crater Co, Cameca, Australian Govt, Dept Ind, Innovat Sci, Res & Tertiary Educ, IMCA, Japan Aerosp Explorat Agcy, Lunar & Planetary Inst, NASA, Planetary Studies Fdn, ThermoFisher Sci ID GRAINS C1 [Nakamura-Messenger, K.] IESCG, Houston, TX USA. [Nakamura-Messenger, K.; Keller, L. P.; Messenger, S.] NASA, Robert M Walker Lab Space Sci, ARES, JSC, Houston, TX USA. [Herzog, G. F.] Rutgers State Univ, Piscataway, NJ USA. [Flynn, G. J.] SUNY Coll Plattsburgh, Plattsburgh, NY 12901 USA. [Taylor, S.] CRREL, Hanover, NH USA. [Wirick, S.] Univ Chicago, CARS, Chicago, IL 60637 USA. EM keiko.nakamura-1@nasa.gov RI Khodja, Hicham/A-1869-2016 NR 8 TC 0 Z9 0 U1 0 U2 2 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1086-9379 J9 METEORIT PLANET SCI JI Meteorit. Planet. Sci. PD JUL PY 2012 VL 47 SU 1 SI SI BP A289 EP A289 PG 1 WC Geochemistry & Geophysics SC Geochemistry & Geophysics GA 987AV UT WOS:000307389700256 ER PT J AU Carlson, AE AF Carlson, Anthony E. TI Public Health and the U.S. Military: A History of the Army Medical Department, 1818-1917 SO JOURNAL OF MILITARY HISTORY LA English DT Book Review C1 [Carlson, Anthony E.] USA, Combat Studies Inst, Ft Leavenworth, KS USA. RP Carlson, AE (reprint author), USA, Combat Studies Inst, Ft Leavenworth, KS USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU SOC MILITARY HISTORY PI LEXINGTON PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA 24450-1600 USA SN 0899-3718 J9 J MILITARY HIST JI J. Mil. Hist. PD JUL PY 2012 VL 76 IS 3 BP 871 EP 873 PG 3 WC History SC History GA 974OJ UT WOS:000306445500022 ER PT J AU Rafuse, ES AF Rafuse, Ethan S. TI Warfare State: World War II Americans and the Age of Big Government SO JOURNAL OF MILITARY HISTORY LA English DT Book Review C1 [Rafuse, Ethan S.] USA, Command & Gen Staff Coll, Ft Leavenworth, KS USA. RP Rafuse, ES (reprint author), USA, Command & Gen Staff Coll, Ft Leavenworth, KS USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU SOC MILITARY HISTORY PI LEXINGTON PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA 24450-1600 USA SN 0899-3718 J9 J MILITARY HIST JI J. Mil. Hist. PD JUL PY 2012 VL 76 IS 3 BP 901 EP 902 PG 2 WC History SC History GA 974OJ UT WOS:000306445500042 ER PT J AU House, JM AF House, Jonathan M. TI Nazi Policy on the Eastern Front, 1941: Total War, Genocide, and Radicalization SO JOURNAL OF MILITARY HISTORY LA English DT Book Review C1 [House, Jonathan M.] USA, Command & Gen Staff Coll, Ft Leavenworth, KS USA. RP House, JM (reprint author), USA, Command & Gen Staff Coll, Ft Leavenworth, KS USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU SOC MILITARY HISTORY PI LEXINGTON PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA 24450-1600 USA SN 0899-3718 J9 J MILITARY HIST JI J. Mil. Hist. PD JUL PY 2012 VL 76 IS 3 BP 906 EP 907 PG 2 WC History SC History GA 974OJ UT WOS:000306445500045 ER PT J AU Giangreco, DM AF Giangreco, D. M. TI Do Unto Others: Counter Bombardment in Australia's Military Campaigns SO JOURNAL OF MILITARY HISTORY LA English DT Book Review C1 [Giangreco, D. M.] Foreign Mil Studies Off, Ft Leavenworth, KS USA. RP Giangreco, DM (reprint author), Foreign Mil Studies Off, Ft Leavenworth, KS USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU SOC MILITARY HISTORY PI LEXINGTON PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA 24450-1600 USA SN 0899-3718 J9 J MILITARY HIST JI J. Mil. Hist. PD JUL PY 2012 VL 76 IS 3 BP 917 EP 919 PG 3 WC History SC History GA 974OJ UT WOS:000306445500053 ER PT J AU Huntsinger, GC Burk, RC Trainor, TE AF Huntsinger, Guy C. Burk, Roger Chapman Trainor, Timothy E. TI The US Army Projects the Effect of Merit Pay on Payroll Growth SO INTERFACES LA English DT Article DE government: defense; organizational studies; manpower planning; motivation/incentives; probability; Markov processes; simulation; systems dynamics AB The National Security Personnel System (NSPS) was designed to provide greater opportunity for merit-based pay raises than the preexisting civil service system. However, a US Army organization was concerned that over time the accumulation of merit raises would make the total payroll unaffordable. We were asked to investigate the conditions under which this situation would be likely to happen. We used the Vensim (R) modeling software to produce a model of the influences and events that would cause payroll to rise or fall from year to year. Our analysis showed that the merit pay policies in place at the start of our study were very likely to lead to undesirable growth in total pay and a concentration of all employees near the maximum allowed salary, defeating the purpose of NSPS-to reward better service with more pay. The most important factors were the fraction of merit pay that was given as merit raises (as opposed to bonuses) and the salaries of people newly hired to replace those who left the organization. We showed how departing senior employees should be replaced with less-senior ones to avoid long-term payroll growth. We used the model to find the combinations of merit pay and new-hire policies that would balance the effect of these two major influences and produce little or no long-term payroll growth. We also showed that some other influences that had concerned the client were actually of small effect compared to the stochastic uncertainty in payroll growth. Another influence, attrition, produced a more substantial effect. The interactive nature of the model allowed real-time exploration of alternatives with the client and helped build confidence in the robustness of the results. These results highlight potential problem areas needing careful analysis in implementing similar merit pay systems. C1 [Huntsinger, Guy C.; Burk, Roger Chapman; Trainor, Timothy E.] US Mil Acad, Dept Syst Engn, West Point, NY 10996 USA. RP Huntsinger, GC (reprint author), US Mil Acad, Dept Syst Engn, West Point, NY 10996 USA. EM guy.huntsinger@us.army.mil; roger.burk@usma.edu; ft5890@usma.edu NR 15 TC 0 Z9 0 U1 0 U2 12 PU INFORMS PI HANOVER PA 7240 PARKWAY DR, STE 310, HANOVER, MD 21076-1344 USA SN 0092-2102 J9 INTERFACES JI Interfaces PD JUL-AUG PY 2012 VL 42 IS 4 BP 395 EP 405 DI 10.1287/inte.1110.0605 PG 11 WC Management; Operations Research & Management Science SC Business & Economics; Operations Research & Management Science GA 984QY UT WOS:000307207500006 ER PT J AU McAllister, QP Gillespie, JW VanLandingham, MR AF McAllister, Quinn P. Gillespie, John W., Jr. VanLandingham, Mark R. TI Evaluation of the three-dimensional properties of Kevlar across length scales SO JOURNAL OF MATERIALS RESEARCH LA English DT Article ID ATOMIC-FORCE MICROSCOPY; INCLUDING SLIDING FRICTION; HIGH-PERFORMANCE FIBERS; WOOD CELL-WALLS; ELASTIC-MODULUS; MECHANICAL-PROPERTIES; POLY(P-PHENYLENE TEREPHTHALAMIDE); NANOINDENTATION MEASUREMENTS; NANOMECHANICAL PROPERTIES; INDENTATION EXPERIMENTS AB In this study, nanoindentation was utilized to measure the local, three-dimensional properties of Kevlar 49 and Kevlar KM2 on the length scales of the fiber microstructure. First, atomic force microscopy-based methods were used to explore the extent of property changes with respect to radial position in the fibers' axial and hoop planes. From these measurements, no significant change in response was found for Kevlar 49 fibers, consistent with transverse isotropy. However, a reduced stiffness "shell" region (up to similar to 300-350 nm thick) was observed for KM2 fibers. Instrumented indentation was then used to evaluate fiber response with respect to orientation and contact size and establish a critical contact size above which the response is independent of indenter size (i.e., "homogeneous" behavior). A previously proposed analytical method for indentation of a transversely isotropic material was used to estimate the local material properties of the Kevlar fibers from the measured homogeneous response. C1 [McAllister, Quinn P.; Gillespie, John W., Jr.] Univ Delaware, Ctr Composite Mat, Dept Mat Sci & Engn, Newark, DE 19716 USA. [VanLandingham, Mark R.] USA, Weap & Mat Res Directorate, Mat & Mfg Sci Div, Res Lab,ATTN RDRL WMM B, Aberdeen Proving Ground, MD 21005 USA. RP Gillespie, JW (reprint author), Univ Delaware, Ctr Composite Mat, Dept Mat Sci & Engn, Newark, DE 19716 USA. EM gillespi@udel.edu FU Army Research Laboratory [W911NF-06-2-0011] FX QM and JWG gratefully acknowledge sponsorship by the Army Research Laboratory under cooperative agreement W911NF-06-2-0011. The views and conclusions contained in this paper should not be interpreted as representing the official policies, either expressed or implied, of the Army Research Laboratory or the U.S. Government. The U.S. Government is authorized to reproduce and distribute reprints for Government purposes not withstanding any copyright notation herein. NR 53 TC 15 Z9 15 U1 1 U2 31 PU CAMBRIDGE UNIV PRESS PI NEW YORK PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA SN 0884-2914 J9 J MATER RES JI J. Mater. Res. PD JUL PY 2012 VL 27 IS 14 BP 1824 EP 1837 DI 10.1557/jmr.2012.80 PG 14 WC Materials Science, Multidisciplinary SC Materials Science GA 984LP UT WOS:000307191500006 ER PT J AU Yoon, IK Getis, A Aldstadt, J Rothman, AL Tannitisupawong, D Koenraadt, CJM Fansiri, T Jones, JW Morrison, AC Jarman, RG Nisalak, A Mammen, MP Thammapalo, S Srikiatkhachorn, A Green, S Libraty, DH Gibbons, RV Endy, T Pimgate, C Scott, TW AF Yoon, In-Kyu Getis, Arthur Aldstadt, Jared Rothman, Alan L. Tannitisupawong, Darunee Koenraadt, Constantianus J. M. Fansiri, Thanyalak Jones, James W. Morrison, Amy C. Jarman, Richard G. Nisalak, Ananda Mammen, Mammen P., Jr. Thammapalo, Suwich Srikiatkhachorn, Anon Green, Sharone Libraty, Daniel H. Gibbons, Robert V. Endy, Timothy Pimgate, Chusak Scott, Thomas W. TI Fine Scale Spatiotemporal Clustering of Dengue Virus Transmission in Children and Aedes aegypti in Rural Thai Villages SO PLOS NEGLECTED TROPICAL DISEASES LA English DT Article ID POLYMERASE-CHAIN-REACTION; PRIMARY-SCHOOL CHILDREN; KAMPHAENG PHET; PUERTO-RICO; VECTOR; CULICIDAE; DIPTERA; BLOOD; PATTERNS; KINETICS AB Background: Based on spatiotemporal clustering of human dengue virus (DENV) infections, transmission is thought to occur at fine spatiotemporal scales by horizontal transfer of virus between humans and mosquito vectors. To define the dimensions of local transmission and quantify the factors that support it, we examined relationships between infected humans and Aedes aegypti in Thai villages. Methodology/Principal Findings: Geographic cluster investigations of 100-meter radius were conducted around DENV-positive and DENV-negative febrile "index" cases (positive and negative clusters, respectively) from a longitudinal cohort study in rural Thailand. Child contacts and Ae. aegypti from cluster houses were assessed for DENV infection. Spatiotemporal, demographic, and entomological parameters were evaluated. In positive clusters, the DENV infection rate among child contacts was 35.3% in index houses, 29.9% in houses within 20 meters, and decreased with distance from the index house to 6.2% in houses 80-100 meters away (p<0.001). Significantly more Ae. aegypti were DENV-infectious (i.e., DENV-positive in head/thorax) in positive clusters (23/1755; 1.3%) than negative clusters (1/1548; 0.1%). In positive clusters, 8.2% of mosquitoes were DENV-infectious in index houses, 4.2% in other houses with DENV-infected children, and 0.4% in houses without infected children (p<0.001). The DENV infection rate in contacts was 47.4% in houses with infectious mosquitoes, 28.7% in other houses in the same cluster, and 10.8% in positive clusters without infectious mosquitoes (p<0.001). Ae. aegypti pupae and adult females were more numerous only in houses containing infectious mosquitoes. Conclusions/Significance: Human and mosquito infections are positively associated at the level of individual houses and neighboring residences. Certain houses with high transmission risk contribute disproportionately to DENV spread to neighboring houses. Small groups of houses with elevated transmission risk are consistent with over-dispersion of transmission (i.e., at a given point in time, people/mosquitoes from a small portion of houses are responsible for the majority of transmission). C1 [Yoon, In-Kyu; Tannitisupawong, Darunee; Jarman, Richard G.; Nisalak, Ananda; Mammen, Mammen P., Jr.; Gibbons, Robert V.; Pimgate, Chusak] Armed Forces Res Inst Med Sci, Dept Virol, Bangkok 10400, Thailand. [Getis, Arthur] San Diego State Univ, Dept Geog, San Diego, CA 92182 USA. [Aldstadt, Jared] SUNY Buffalo, Dept Geog, Buffalo, NY 14260 USA. [Rothman, Alan L.] Univ Rhode Isl, Inst Immunol & Informat, Providence, RI 02908 USA. [Koenraadt, Constantianus J. M.] Wageningen Univ, Entomol Lab, Wageningen, Netherlands. [Fansiri, Thanyalak; Jones, James W.] Armed Forces Res Inst Med Sci, Dept Entomol, Bangkok 10400, Thailand. [Morrison, Amy C.; Scott, Thomas W.] Univ Calif Davis, Dept Entomol, Davis, CA 95616 USA. [Thammapalo, Suwich] Thailand Minist Publ Hlth, Dept Dis Control, Bur Vector Borne Dis, Nonthaburi, Thailand. [Srikiatkhachorn, Anon; Green, Sharone; Libraty, Daniel H.] Univ Massachusetts, Div Infect Dis & Immunol, Dept Med, Sch Med, Worcester, MA USA. [Endy, Timothy] SUNY Syracuse, Dept Infect Dis, Syracuse, NY USA. [Scott, Thomas W.] NIH, Fogarty Int Ctr, Bethesda, MD 20892 USA. RP Yoon, IK (reprint author), Armed Forces Res Inst Med Sci, Dept Virol, Bangkok 10400, Thailand. EM Yooni@afrims.org RI Aldstadt, Jared/A-8508-2009 OI Aldstadt, Jared/0000-0001-9162-7439 FU U.S. National Institutes of Health [P01 AI34533, R01 GM083224]; U.S. Military Infectious Diseases Research Program [S0016-04-AF]; Bill and Melinda Gates Foundation Global Health [OPP52250] FX This work was supported by the U.S. National Institutes of Health (grant numbers P01 AI34533, R01 GM083224); U.S. Military Infectious Diseases Research Program (grant number S0016-04-AF); and The Bill and Melinda Gates Foundation Global Health (grant number OPP52250). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 37 TC 49 Z9 50 U1 3 U2 27 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1935-2735 J9 PLOS NEGLECT TROP D JI Plos Neglect. Trop. Dis. PD JUL PY 2012 VL 6 IS 7 AR e1730 DI 10.1371/journal.pntd.0001730 PG 9 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA 983ES UT WOS:000307101900023 PM 22816001 ER PT J AU McDermott, RN AF McDermott, Roger N. TI The Shanghai Cooperation Organization's Impact on Central Asian Security A View from Kazakhstan SO PROBLEMS OF POST-COMMUNISM LA English DT Article AB The focus of Western experts and policy makers on China and Russia may distort their understanding of how the Shanghai Cooperation Organization operates. C1 [McDermott, Roger N.] Jamestown Fdn, Washington, DC USA. [McDermott, Roger N.] FMSO, Ft Leavenworth, KS USA. RP McDermott, RN (reprint author), Jamestown Fdn, Washington, DC USA. NR 43 TC 2 Z9 2 U1 3 U2 12 PU M E SHARPE INC PI ARMONK PA 80 BUSINESS PARK DR, ARMONK, NY 10504 USA SN 1075-8216 J9 PROBL POST-COMMUNISM JI Probl. Post-Communism PD JUL-AUG PY 2012 VL 59 IS 4 BP 56 EP 65 DI 10.2753//PPC1075-8216590405 PG 10 WC Political Science SC Government & Law GA 989KW UT WOS:000307559700005 ER PT J AU Chiles, D Larson, N Pinsker, JE AF Chiles, Daniel Larson, Noelle Pinsker, Jordan E. TI What is the diagnosis? Graves disease with anasarca. SO ENDOCRINE PRACTICE LA English DT Editorial Material C1 [Pinsker, Jordan E.] Tripler Army Med Ctr, Dept Pediat, Div Pediat Endocrinol, Mail Code MCHK PE, Honolulu, HI 96859 USA. [Larson, Noelle] Uniformed Serv Univ Hlth Sci, Dept Pediat, Bethesda, MD 20814 USA. RP Pinsker, JE (reprint author), Tripler Army Med Ctr, Dept Pediat, Div Pediat Endocrinol, Mail Code MCHK PE, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM jordan.pinsker@us.army.mil NR 3 TC 0 Z9 0 U1 0 U2 1 PU AMER ASSOC CLINICAL ENDOCRINOLOGISTS PI JACKSONVILLE PA 245 RIVERSIDE AVENUE, STE 200, JACKSONVILLE, FL 32202 USA SN 1530-891X J9 ENDOCR PRACT JI Endocr. Pract. PD JUL-AUG PY 2012 VL 18 IS 4 BP 619 EP 619 DI 10.4158/EP12044.VV PG 1 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA 981BU UT WOS:000306941300027 PM 22548952 ER PT J AU Hildebrand, MAJCL AF Hildebrand, M. A. J. Charlotte L. TI Untitled SO JOURNAL OF HEALTHCARE MANAGEMENT LA English DT Editorial Material C1 Tripler Army Med Ctr, Honolulu, HI 96859 USA. RP Hildebrand, MAJCL (reprint author), Tripler Army Med Ctr, Honolulu, HI 96859 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER COLL HEALTHCARE EXEC HEALTH ADMINISTRATION PRESS PI CHICAGO PA ONE NORTH FRANKLIN ST SUITE 1700, CHICAGO, IL 60606 USA SN 1096-9012 J9 J HEALTHC MANAG JI J. Healthc. Manag. PD JUL-AUG PY 2012 VL 57 IS 4 BP 274 EP 275 PG 2 WC Health Policy & Services SC Health Care Sciences & Services GA 981QL UT WOS:000306984300008 ER PT J AU Bhagwat, MJ Ormiston, RA Saberi, HA Xin, H AF Bhagwat, Mahendra J. Ormiston, Robert A. Saberi, Hossein A. Xin, Hong TI Application of Computational Fluid Dynamics/Computational Structural Dynamics Coupling for Analysis of Rotorcraft Airloads and Blade Loads in Maneuvering Flight SO JOURNAL OF THE AMERICAN HELICOPTER SOCIETY LA English DT Article AB This paper presents coupled calculations of both the airloads and structural loads for the UH-60A main rotor during the UTTAS pull-up maneuver performed under the NASA/Army UH-60A Airloads Program. These calculations were performed using OVERFLOW-2, a computational fluid dynamics (CFD) solver, coupled to the Rotorcraft Comprehensive Analysis System (RCAS), a rotorcraft comprehensive analysis. For time-varying maneuvers, the two codes were tightly coupled and exchanged airloads and structural deflections at every time step. The coupled solution methodology gives improved airload prediction because of the ability to model three-dimensional transonic effects on the advancing blade, stall events on the retreating blade, as well as the aeroelastic deformations. Correlation with data for both the airloads and structural loads is reasonably good. Control load predictions also show good correlation with data, which is a substantial improvement over conventional analyses. A quasisteady loosely coupled approximate solution was also examined and was found to give good airload and structural load predictions, for this relatively slow maneuver. C1 [Bhagwat, Mahendra J.; Ormiston, Robert A.] USA, AMRDEC, RDECOM, Aeroflightdynam Directorate, Moffett Field, CA USA. [Saberi, Hossein A.; Xin, Hong] Adv Rotorcraft Technol Inc, Sunnyvale, CA USA. RP Bhagwat, MJ (reprint author), USA, AMRDEC, RDECOM, Aeroflightdynam Directorate, Moffett Field, CA USA. EM mahendra.bhagwat@us.army.mil NR 19 TC 6 Z9 6 U1 0 U2 7 PU AMER HELICOPTER SOC INC PI ALEXANDRIA PA 217 N WASHINGTON ST, ALEXANDRIA, VA 22314 USA SN 0002-8711 J9 J AM HELICOPTER SOC JI J. Am. Helicopter Soc. PD JUL PY 2012 VL 57 IS 3 AR 032007 DI 10.4050/JAHS.57.032007 PG 21 WC Engineering, Aerospace SC Engineering GA 983BA UT WOS:000307090000007 ER PT J AU Moodie, AM Yeo, H AF Moodie, Alex M. Yeo, Hyeonsoo TI Design of a Cruise-Efficient Compound Helicopter SO JOURNAL OF THE AMERICAN HELICOPTER SOCIETY LA English DT Article; Proceedings Paper CT 67th Annual Forum of the American-Helicopter-Society CY MAY 03-05, 2011 CL Virginia Beach, VA SP Amer Helicopter Soc AB A slowed-rotor compound helicopter is conceptually designed using a multitidelity approach, showing the potential for significant efficiency improvements above conventional helicopters. The cruise tip speed and bilinear twist distribution are optimized using the Comprehensive Analytical Model of Rotorcraft Aerodynamics and Dynamics (CAMRAD II). System-level metrics are computed using the NASA Design and Analysis of RotorCraft (NDARC) program to show top-level payoffs. An aeroperformance map is generated using comprehensive analysis for the optimum twist distribution, providing calibration data for the main rotor model within NDARC. Effects of disk loading and wing loading on the size of the slowed-rotor compound helicopter are analyzed, and off-design performance is computed. Rotor wing interference effects are analyzed using CAMRAD II for several wing vertical locations. C1 [Moodie, Alex M.; Yeo, Hyeonsoo] NASA, Aeroflightdynam Directorate AMRDEC, USA, Res Dev & Engn Command,Ames Res Ctr, Moffett Field, CA USA. RP Moodie, AM (reprint author), NASA, Aeroflightdynam Directorate AMRDEC, USA, Res Dev & Engn Command,Ames Res Ctr, Moffett Field, CA USA. EM alex.moodie@us.army.mil NR 15 TC 1 Z9 2 U1 0 U2 2 PU AMER HELICOPTER SOC INC PI ALEXANDRIA PA 217 N WASHINGTON ST, ALEXANDRIA, VA 22314 USA SN 0002-8711 J9 J AM HELICOPTER SOC JI J. Am. Helicopter Soc. PD JUL PY 2012 VL 57 IS 3 AR 032004 DI 10.4050/JAHS.57.032004 PG 11 WC Engineering, Aerospace SC Engineering GA 983BA UT WOS:000307090000004 ER PT J AU Sekula, MK Wilbur, ML AF Sekula, Martin K. Wilbur, Matthew L. TI Analysis of a Multiflap Control System for a Swashplateless Rotor SO JOURNAL OF THE AMERICAN HELICOPTER SOCIETY LA English DT Article; Proceedings Paper CT 67th Annual Forum of the American-Helicopter-Society CY MAY 03-05, 2011 CL Virginia Beach, VA SP Amer Helicopter Soc ID TRAILING-EDGE FLAPS; DESIGN AB An analytical study was conducted examining the feasibility of a swashplateless rotor controlled through two trailing-edge flaps (TEFs), where the cyclic and collective controls were provided by separate TEFs. This analysis included a parametric study examining the impact of various design parameters on TEF deflections. Blade pitch bearing stiffness; blade pitch index; and flap chord, span, location, and control function of the inboard and outboard flaps were systematically varied on a utility-class rotorcraft trimmed in steady level flight. Gradient-based optimizations minimizing flap deflections were performed to identify single- and two-TEF swashplateless rotor designs. Steady, forward flight analysis suggest that a two-TEF swashplateless rotor where the outboard flap provides cyclic control and inboard flap provides collective control can reduce TEF deflection requirements without a significant impact on power, compared to a single-TEF swashplateless rotor design. C1 [Sekula, Martin K.] NASA, Langley Res Ctr, Hampton, VA 23665 USA. [Wilbur, Matthew L.] USA, Res Lab, Hampton, VA USA. RP Sekula, MK (reprint author), NASA, Langley Res Ctr, Hampton, VA 23665 USA. EM martin.k.sekula@nasa.gov NR 16 TC 1 Z9 1 U1 0 U2 3 PU AMER HELICOPTER SOC INC PI ALEXANDRIA PA 217 N WASHINGTON ST, ALEXANDRIA, VA 22314 USA SN 0002-8711 J9 J AM HELICOPTER SOC JI J. Am. Helicopter Soc. PD JUL PY 2012 VL 57 IS 3 AR 032006 DI 10.4050/JAHS.57.032006 PG 12 WC Engineering, Aerospace SC Engineering GA 983BA UT WOS:000307090000006 ER PT J AU Rasmussen, TE DuBose, JJ Asensio, JA Feliciano, DV Fox, CJ Nunez, TC Sise, MJ AF Rasmussen, Todd E. DuBose, Joseph J. Asensio, Juan A. Feliciano, David V. Fox, Charles J. Nunez, Timothy C. Sise, Michael J. CA Amer Assoc Surg Trauma TI Tourniquets, vascular shunts, and endovascular technologies: Esoteric or essential? A report from the 2011 AAST Military Liaison Panel SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY LA English DT Editorial Material ID HEMORRHAGIC-SHOCK; BALLOON OCCLUSION; PORCINE MODEL; TRAUMA; MANAGEMENT; SURVIVAL; WARTIME; ADJUNCT; INJURY; AORTA C1 [Rasmussen, Todd E.; Nunez, Timothy C.] USA, Inst Surg Res, San Antonio Mil Med Ctr, San Antonio, TX USA. [DuBose, Joseph J.] Univ Maryland, R Adams Cowley Shock Trauma Ctr, Baltimore, MD 21201 USA. [Asensio, Juan A.] Univ Miami, Miller Sch Med, Ryder Trauma Ctr, Miami, FL 33136 USA. [Feliciano, David V.] Mercer Univ, Sch Med, Atlanta Med Ctr, Macon, GA 31207 USA. [Feliciano, David V.] Mercer Univ, Sch Med, Med Ctr Cent Georgia, Macon, GA 31207 USA. [Fox, Charles J.] Uniformed Serv Univ Hlth Sci, Walter Reed Natl Mil Med Ctr, Bethesda, MD 20814 USA. [Rasmussen, Todd E.; Asensio, Juan A.; Feliciano, David V.; Fox, Charles J.; Sise, Michael J.] Uniformed Serv Univ Hlth Sci, Norman M Rich Dept Surg, Bethesda, MD 20814 USA. [Sise, Michael J.] Scripps Mercy Hosp, San Diego, CA USA. RP Rasmussen, TE (reprint author), USA, Inst Surg Res, 3400 Rawley E Chambers,Suite B, Ft Sam Houston, TX 78234 USA. EM todd.rasmussen@amedd.army.mil NR 14 TC 8 Z9 9 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 2163-0755 J9 J TRAUMA ACUTE CARE JI J. Trauma Acute Care Surg. PD JUL PY 2012 VL 73 IS 1 BP 282 EP 285 DI 10.1097/TA.0b013e3182569df4 PG 4 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 979JU UT WOS:000306814100042 PM 22743396 ER PT J AU Javitt, MC Hendrick, RE Keen, JD Jorgensen, KJ Orton, CG AF Javitt, Marcia C. Hendrick, R. Edward Keen, John D. Jorgensen, Karsten Juhl Orton, Colin G. TI Recent data show that mammographic screening of asymptomatic women is effective and essential SO MEDICAL PHYSICS LA English DT Editorial Material ID BREAST-CANCER MORTALITY; RANDOMIZED CONTROLLED-TRIALS; OVERDIAGNOSIS; REDUCTION; NORWAY; TRENDS; IMPACT; DEATH; RISK C1 [Javitt, Marcia C.] Uniformed Serv Univ Hlth Sci, Walter Reed Army Med Ctr, Washington, DC 20307 USA. [Hendrick, R. Edward] Univ Colorado Denver, Tinmath, CO 80547 USA. [Keen, John D.] John H Stroger Jr Hosp, Chicago, IL 60612 USA. [Jorgensen, Karsten Juhl] Univ Copenhagen, Rigshosp, Nord Cochrane Ctr, DK-2100 Copenhagen, Denmark. RP Javitt, MC (reprint author), Uniformed Serv Univ Hlth Sci, Walter Reed Army Med Ctr, Washington, DC 20307 USA. EM femscan@aol.com; edward.hendrick@gmail.com; jkeen@cookcountyhhs.org; kj@cochrane.dk NR 32 TC 2 Z9 2 U1 0 U2 4 PU AMER ASSOC PHYSICISTS MEDICINE AMER INST PHYSICS PI MELVILLE PA STE 1 NO 1, 2 HUNTINGTON QUADRANGLE, MELVILLE, NY 11747-4502 USA SN 0094-2405 J9 MED PHYS JI Med. Phys. PD JUL PY 2012 VL 39 IS 7 BP 4047 EP 4050 DI 10.1118/1.3694115 PG 4 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA 980KV UT WOS:000306893000001 PM 22830737 ER PT J AU Endale, M Ekberg, A Akala, HM Alao, JP Sunnerhagen, P Yenesew, A Erdelyi, M AF Endale, Milkyas Ekberg, Annabel Akala, Hoseah M. Alao, John Patrick Sunnerhagen, Per Yenesew, Abiy Erdelyi, Mate TI Busseihydroquinones A-D from the Roots of Pentas bussei SO JOURNAL OF NATURAL PRODUCTS LA English DT Article ID MEDICINAL-PLANTS; COMPLETE PROTON; LONGIFLORA; MALARIA; NMR; TRANS-3,4-DIHYDROXY-3,4-DIHYDROMOLLUGIN; PYRANONAPHTHOQUINONE; PENTALONGIN; STEM AB Four new naphthohydroquinones, named busseihydroquinones A-D (1-4), along with a known homoprenylated dihydronaphthoquinone (5), were isolated from the CH2Cl2/MeOH (1:1) extract of the roots of Pentas bussei. Although the genus Pentas is frequently used by traditional healers for the treatment of malaria, only marginal activities against the chloroquine-sensitive (D6) and the chloroquine-resistant (W2) strains of Plasmodium falciparum were observed for the crude root extract and the isolated constituents of this plant. C1 [Endale, Milkyas; Yenesew, Abiy] Univ Nairobi, Dept Chem, Nairobi, Kenya. [Endale, Milkyas; Ekberg, Annabel; Alao, John Patrick; Sunnerhagen, Per; Erdelyi, Mate] Univ Gothenburg, Dept Chem & Mol Biol, SE-41296 Gothenburg, Sweden. [Ekberg, Annabel; Erdelyi, Mate] Univ Gothenburg, Swedish NMR Ctr, SE-40530 Gothenburg, Sweden. [Akala, Hoseah M.] USA, Med Res Unit Kenya, APO, AE 09831 USA. RP Yenesew, A (reprint author), Univ Nairobi, Dept Chem, POB 30197-00100, Nairobi, Kenya. EM ayenesew@uonbi.ac.ke; mate@chem.gu.se RI Erdelyi, Mate/A-3686-2009; Sunnerhagen, Per/G-1696-2012 OI Erdelyi, Mate/0000-0003-0359-5970; Sunnerhagen, Per/0000-0002-0967-8729 FU Swedish Research Council [VR2007-4407]; International Science Program, Sweden [KEN-02]; Swedish Institute [210/00154/2010]; NAPRECA FX We acknowledge the Swedish Research Council (VR2007-4407), International Science Program, Sweden (KEN-02), and the Swedish Institute (210/00154/2010) as funding sources.; We are grateful to F. L. Eyase (U.S. Army Medical Research Unit-Kenya, MRU 64109), M. Mbugua, A. Ndakala, and A. O. Yusuf (Dept. of Chemistry, University of Nairobi) for helpful advice. M. Endale is thankful to NAPRECA and to the Swedish Institute for financial support. J.P.A. and P.S. acknowledge the Chemical Biology Platform at the University of Gothenburg. M. Erdelyi acknowledges the support of the Swedish Research Council (VR2007-4407). A.Y. is thankful to the International Science Program, Sweden, for a research grant (KEN-02). NR 27 TC 5 Z9 5 U1 0 U2 2 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0163-3864 J9 J NAT PROD JI J. Nat. Prod. PD JUL PY 2012 VL 75 IS 7 BP 1299 EP 1304 DI 10.1021/np3002223 PG 6 WC Plant Sciences; Chemistry, Medicinal; Pharmacology & Pharmacy SC Plant Sciences; Pharmacology & Pharmacy GA 978ZE UT WOS:000306783500007 PM 22709138 ER PT J AU Brunell, MK AF Brunell, Marla K. TI Comparison of Noncontact Infrared Thermometry and 3 Commercial Subcutaneous Temperature Transponding Microchips with Rectal Thermometry in Rhesus Macaques (Macaca mulatta) SO JOURNAL OF THE AMERICAN ASSOCIATION FOR LABORATORY ANIMAL SCIENCE LA English DT Article ID OBTAINING BODY-TEMPERATURE; INTENSIVE-CARE UNIT; CORE TEMPERATURE; PULMONARY-ARTERY; PIGS; DOGS; MICE AB This study compared a noncontact infrared laser thermometer and 3 different brands of subcutaneous temperature transponding microchips with rectal thermometry in 50 rhesus macaques (Macaca mulatta). The data were analyzed by using intraclass correlation coefficients and limits of agreement. In addition, the technical capabilities and practicality of the thermometers in the clinical setting were reviewed. None of the alternative techniques investigated was equivalent to rectal thermometry in rhesus macaques. Temperatures obtained by using microchips had higher correlation and agreed more closely with rectal temperatures than did those obtained by the noncontact infrared method. However, transponding microchips did not yield consistent results. Due to difficulty in positioning nonsedated macaques in their homecage, subcutaneous microchips were not practical in the clinical setting. Furthermore, pair-housed macaques may be able to break or remove microchips from their cagemates. C1 USN, Med Res Ctr, Vet Serv Program, Walter Reed Army Inst Res, Silver Spring, MD USA. RP Brunell, MK (reprint author), USN, Med Res Ctr, Vet Serv Program, Walter Reed Army Inst Res, Silver Spring, MD USA. EM marla.brunell@us.army.mil FU Walter Reed Army Institute of Research FX This work was performed at Walter Reed Army Institute of Research, Naval Medical Research Center, Silver Spring, MD, USA 20912-7500, and was funded by the Walter Reed Army Institute of Research. There is no objection to its presentation or publication. The opinions and assertions contained herein are the private ones of the author and are not to be construed as such or reflecting the views of the Department of Defense. Research was conducted in compliance with the Animal Welfare Act and other federal statutes and regulations relating to animals and experiments involving animals and adheres to principles stated in the Guide for the Care and Use of Laboratory Annuals, NRC Publication, 2011 edition. NR 21 TC 9 Z9 9 U1 0 U2 11 PU AMER ASSOC LABORATORY ANIMAL SCIENCE PI MEMPHIS PA 9190 CRESTWYN HILLS DR, MEMPHIS, TN 38125 USA SN 1559-6109 J9 J AM ASSOC LAB ANIM JI J. Amer. Assoc. Lab. Anim. Sci. PD JUL PY 2012 VL 51 IS 4 BP 479 EP 484 PG 6 WC Veterinary Sciences; Zoology SC Veterinary Sciences; Zoology GA 978UY UT WOS:000306772500016 PM 23043815 ER PT J AU Facemire, PR Facemire, LM Honnold, SP AF Facemire, Paul R. Facemire, Lynn M. Honnold, Shelley P. TI Peripheral primitive neuroectodermal tumor in a two-year-old paint horse SO JOURNAL OF VETERINARY DIAGNOSTIC INVESTIGATION LA English DT Article DE Horses; neoplasia; primitive neuroectodermal tumor ID EWINGS-SARCOMA; NERVE AB A 2-year-old gelding presented with a history of lethargy and anorexia. Physical examination revealed pleural and abdominal fluid, as well as several masses in the scrotum. The horse became acutely dyspneic despite 7 days of supportive care. Because of the poor prognosis, the owners elected euthanasia. Gross necropsy findings included multiple masses in the scrotum and inguinal canals and along the dorsal peritoneal cavity. The neoplasm infiltrated the kidneys, liver, spleen, mesenteric lymph nodes, mesentery, and abdominal surface of the diaphragm. Histologically, the neoplasm is composed of spindle to round cells arranged in densely cellular areas, vague streams, and rare rosettes. Neoplastic cells were immunoreactive for S-100 protein, glial fibrillary acidic protein, neuron-specific enolase, neurofilament protein, and synaptophysin. Based on gross, histological, and immunohistochemical findings, a diagnosis of peripheral primitive neuroectodermal tumor was made. Primitive neuroectodermal tumors are rarely described in horses that were associated with the eyes. C1 [Facemire, Paul R.; Honnold, Shelley P.] Armed Forces Inst Pathol, Dept Vet Pathol, Washington, DC 20306 USA. [Facemire, Lynn M.] Monocacy Equine Associates, Bealsville, MD USA. RP Facemire, PR (reprint author), USA, Med Res Inst Infect Dis, Dept Pathol, 1425 Porter St, Ft Detrick, MD 21702 USA. EM paul.facemire@us.army.mil NR 18 TC 1 Z9 2 U1 0 U2 3 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 1040-6387 J9 J VET DIAGN INVEST JI J. Vet. Diagn. Invest. PD JUL PY 2012 VL 24 IS 4 BP 794 EP 796 DI 10.1177/1040638712446505 PG 3 WC Veterinary Sciences SC Veterinary Sciences GA 983KR UT WOS:000307118700027 PM 22621943 ER PT J AU Pasiakos, SM AF Pasiakos, Stefan M. TI Exercise and Amino Acid Anabolic Cell Signaling and the Regulation of Skeletal Muscle Mass SO NUTRIENTS LA English DT Review DE mechanotransduction; leucine; hypertrophy; mTORC1; protein synthesis ID STIMULATES PROTEIN-SYNTHESIS; GROWTH-RELATED GENES; P70 S6 KINASE; RESISTANCE EXERCISE; MAMMALIAN TARGET; OLDER-ADULTS; YOUNG MEN; TRANSPORTER EXPRESSION; PHOSPHATIDIC-ACID; BODY-COMPOSITION AB A series of complex intracellular networks influence the regulation of skeletal muscle protein turnover. In recent years, studies have examined how cellular regulators of muscle protein turnover modulate metabolic mechanisms contributing to the loss, gain, or conservation of skeletal muscle mass. Exercise and amino acids both stimulate anabolic signaling potentially through several intracellular pathways including the mammalian target of rapamycin complex 1 and the mitogen activated protein kinase cell signaling cascades. As novel molecular regulators of muscle integrity continue to be explored, a contemporary analysis of the literature is required to understand the metabolic mechanisms by which contractile forces and amino acids affect cellular process that contribute to long-term adaptations and preservation of muscle mass. This article reviews the literature related to how exercise and amino acid availability affect cellular regulators of skeletal muscle mass, especially highlighting recent investigations that have identified mechanisms by which contractile forces and amino acids modulate muscle health. Furthermore, this review will explore integrated exercise and nutrition strategies that promote the maintenance of muscle health by optimizing exercise, and amino acid-induced cell signaling in aging adults susceptible to muscle loss. C1 USA, Mil Nutr Div, Environm Med Res Inst, Natick, MA 01760 USA. RP Pasiakos, SM (reprint author), USA, Mil Nutr Div, Environm Med Res Inst, 15 Kansas St,Bldg 42, Natick, MA 01760 USA. EM stefan.pasiakos@us.army.mil RI Pasiakos, Stefan/E-6295-2014 OI Pasiakos, Stefan/0000-0002-5378-5820 NR 100 TC 15 Z9 15 U1 0 U2 20 PU MDPI AG PI BASEL PA POSTFACH, CH-4005 BASEL, SWITZERLAND SN 2072-6643 J9 NUTRIENTS JI Nutrients PD JUL PY 2012 VL 4 IS 7 BP 740 EP 758 DI 10.3390/nu4070740 PG 19 WC Nutrition & Dietetics SC Nutrition & Dietetics GA 979EY UT WOS:000306799800012 PM 22852061 ER PT J AU Swearingen, ME Swanson, DC AF Swearingen, Michelle E. Swanson, David C. TI A Numerical Model for Point Source Scattering from an Impedance Cylinder Placed Normal to an Impedance Plane SO ACTA ACUSTICA UNITED WITH ACUSTICA LA English DT Article ID SOUND-PROPAGATION; GROUND SURFACE; HALF-SPACE; DIFFRACTION; ATTENUATION; BOUNDARY; TREES; NOISE AB A semi-analytic model that couples acoustic propagation over an impedance plane and scattering from an semi-infinite right cylinder with finite impedance placed normal to the impedance plane is developed mathematically and verified with benchmark cases. Model output is found to be sensitive to large changes in temperature. Large changes in non-rigid ground and cylinder impedances also significantly impact results. The model is only valid near the impedance boundary. Minimum numbers of integration points and summation terms are determined. C1 [Swearingen, Michelle E.; Swanson, David C.] Penn State Univ, Grad Program Acoust, University Pk, PA 16802 USA. RP Swearingen, ME (reprint author), USA, Construct Engn Res Lab, Engn Res & Dev Ctr, Champaign, IL 61826 USA. EM Michelle.E.Swearingen@usace.army.mil NR 22 TC 2 Z9 2 U1 0 U2 5 PU S HIRZEL VERLAG PI STUTTGART PA POSTFACH 10 10 61, D-70 009 STUTTGART, GERMANY SN 1610-1928 J9 ACTA ACUST UNITED AC JI Acta Acust. United Acust. PD JUL-AUG PY 2012 VL 98 IS 4 BP 523 EP 533 DI 10.3813/AAA.918534 PG 11 WC Acoustics SC Acoustics GA 974TE UT WOS:000306459100001 ER PT J AU Lindsay, DL Edwards, CE Jung, MG Bailey, P Lance, RF AF Lindsay, Denise L. Edwards, Christine E. Jung, Michael G. Bailey, Pamela Lance, Richard F. TI NOVEL MICROSATELLITE LOCI FOR AGAVE PARRYI AND CROSS-AMPLIFICATION IN AGAVE PALMERI (AGAVACEAE) SO AMERICAN JOURNAL OF BOTANY LA English DT Article DE 454 sequencing; Agavaceae; Agave palmeri; Agave parryi; microsatellites; polyploidy AB Premise of the study: To examine the foraging behavior of nectarivorous bats in southeastern Arizona, we developed microsatellite primers in Agave parryi. These markers were also tested for cross-amplification and applicability to assess patterns of genetic diversity and structure in A. palmeri. Methods and Results: Utilizing DNA sequence data from 454 shotgun sequencing, we identified seven novel polymorphic microsatellite loci in A. parryi and screened them for cross-amplification in A. palmeri. These markers were characterized in two populations of 30 individuals each for each species. In A. parryi, all primers were polymorphic and amplified between three and 12 alleles per population. In A. palmeri, all primers amplified, six were polymorphic, and allelic diversity ranged from one to 16 alleles per population. Conclusions: Our results demonstrate the applicability of these microsatellite primers for population genetics studies in both A. parryi and A. palmeri C1 [Lindsay, Denise L.; Edwards, Christine E.; Jung, Michael G.; Bailey, Pamela; Lance, Richard F.] USA, Environm Lab, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Lindsay, DL (reprint author), USA, Environm Lab, Engineer Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM denise.l.lindsay@usace.army.mil OI Edwards, Christine/0000-0001-8837-4872 NR 9 TC 4 Z9 4 U1 0 U2 7 PU BOTANICAL SOC AMER INC PI ST LOUIS PA PO BOX 299, ST LOUIS, MO 63166-0299 USA SN 0002-9122 J9 AM J BOT JI Am. J. Bot. PD JUL PY 2012 VL 99 IS 7 BP E295 EP E297 DI 10.3732/ajb.1200033 PG 3 WC Plant Sciences SC Plant Sciences GA 975IN UT WOS:000306505000010 PM 22753814 ER PT J AU Meguerdichian, DA Heiner, JD Younggren, BN AF Meguerdichian, David A. Heiner, Jason D. Younggren, Bradley N. TI Emergency Medicine Simulation: A Resident's Perspective SO ANNALS OF EMERGENCY MEDICINE LA English DT Editorial Material ID HIGH-FIDELITY SIMULATION; HUMAN PATIENT SIMULATOR; HEALTH-CARE; DELIBERATE PRACTICE; STUDENT PROCEDURES; HOUR RESTRICTIONS; TEAM PERFORMANCE; VIRTUAL PATIENTS; DUTY HOURS; EDUCATION C1 [Meguerdichian, David A.] Boston Med Ctr, Dept Emergency Med, Boston, MA USA. [Heiner, Jason D.] Brooke Army Med Ctr, Dept Emergency Med, Ft Sam Houston, TX 78234 USA. [Younggren, Bradley N.] Madigan Army Med Ctr, Andersen Simulat Ctr, Ft Lewis, WA USA. RP Meguerdichian, DA (reprint author), Brigham & Womens Hosp, Dept Emergency Med, 75 Francis St, Boston, MA 02115 USA. EM dmeguerdichian@partners.org NR 69 TC 5 Z9 5 U1 0 U2 5 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0196-0644 J9 ANN EMERG MED JI Ann. Emerg. Med. PD JUL PY 2012 VL 60 IS 1 BP 121 EP 126 DI 10.1016/j.annemergmed.2011.08.011 PG 6 WC Emergency Medicine SC Emergency Medicine GA 975HQ UT WOS:000306501700026 PM 21944898 ER PT J AU Zhang, HC Nasrabadi, NM Zhang, YN Huang, TS AF Zhang, Haichao Nasrabadi, Nasser M. Zhang, Yanning Huang, Thomas S. TI Multi-View Automatic Target Recognition using Joint Sparse Representation SO IEEE TRANSACTIONS ON AEROSPACE AND ELECTRONIC SYSTEMS LA English DT Article ID MULTIPLE-MEASUREMENT VECTORS; RESOLUTION RADAR SIGNATURES; SIGNAL RECOVERY; IDENTIFICATION AB We introduce a novel joint sparse representation based multi-view automatic target recognition (ATR) method, which can not only handle multi-view ATR without knowing the pose but also has the advantage of exploiting the correlations among the multiple views of the same physical target for a single joint recognition decision. Extensive experiments have been carried out on moving and stationary target acquisition and recognition (MSTAR) public database to evaluate the proposed method compared with several state-of-the-art methods such as linear support vector machine (SVM), kernel SVM, as well as a sparse representation based classifier (SRC). Experimental results demonstrate that the proposed joint sparse representation ATR method is very effective and performs robustly under variations such as multiple joint views, depression, azimuth angles, target articulations, as well as configurations. C1 [Zhang, Yanning] Northwestern Polytech Univ, Sch Comp Sci & Technol, Xian 710129, Peoples R China. [Nasrabadi, Nasser M.] USA, Res Lab, Adelphi, MD 20783 USA. [Zhang, Haichao] Univ Illinois, Dept Elect & Comp Engn, Beckman Inst, Urbana, IL 61801 USA. RP Zhang, HC (reprint author), Univ Illinois, Dept Elect & Comp Engn, Beckman Inst, Urbana, IL 61801 USA. EM hczhang1@gmail.com FU U.S. Army Research Laboratory; U.S. Army Research Office [W911NF-09-1-0383]; National Natural Science Foundation of China [60872145, 60903126]; National High Technology Research and Development Program (863) of China [2009AA01Z315]; China Postdoctoral (Special) Science Foundation [20090451397, 201003685]; Ministry of Education of China [708085] FX The work is supported by the U.S. Army Research Laboratory and U.S. Army Research Office under Grant W911NF-09-1-0383. This work is also supported by the National Natural Science Foundation of China (60872145, 60903126), National High Technology Research and Development Program (863) of China (2009AA01Z315), China Postdoctoral (Special) Science Foundation (20090451397, 201003685) and Cultivation Fund of the Key Scientific and Technical Innovation Project from Ministry of Education of China (708085). NR 49 TC 45 Z9 53 U1 1 U2 17 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0018-9251 J9 IEEE T AERO ELEC SYS JI IEEE Trans. Aerosp. Electron. Syst. PD JUL PY 2012 VL 48 IS 3 BP 2481 EP 2497 DI 10.1109/TAES.2012.6237604 PG 17 WC Engineering, Aerospace; Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA 975ND UT WOS:000306517100040 ER PT J AU Yang, C Kaplan, L Blasch, E AF Yang, Chun Kaplan, Lance Blasch, Erik TI Performance Measures of Covariance and Information Matrices in Resource Management for Target State Estimation SO IEEE TRANSACTIONS ON AEROSPACE AND ELECTRONIC SYSTEMS LA English DT Article ID DISTRIBUTED SENSOR NETWORK; WAVE-FORM SELECTION; NODE SELECTION; TRACKING; LOCALIZATION; FUSION; COORDINATION; PLACEMENT; SYSTEMS AB In target tracking, sensor resource management (SRM) assigns to each target a best combination of sensors, which requires performance analysis of track filter updates. Two popular implementations of track filters are the Kalman filter (or covariance filter) and the information filter. SRM with Kalman filters attempts to minimize the estimation error covariance matrix-based scalar performance measures, whereas SRM with information filters aims to maximize the information matrix-based counterpart. In this paper, we investigate issues related to scalar performance measures and, in particular, compare the use of trace, determinant, and eigenvalues of the covariance matrix or information matrix as scalar performance measures. The study demonstrates which matrix measures are appropriate for resource management applications. Furthermore, the study shows when the matrix measures lead to equivalent goals. While this analysis is agnostic to the type of measurement, the paper demonstrates how to accommodate bearing and range measurements. Overall, the analysis provides insight about how sensor measurements best reduce uncertainty so that we can properly exploit performance measures to satisfy requirements of practical tracking and SRM applications. C1 [Yang, Chun] Sigtem Technol Inc, San Mateo, CA 94402 USA. [Kaplan, Lance] USA, Res Lab, Adelphi, MD 20783 USA. [Blasch, Erik] USAF, Res Lab, Wright Patterson AFB, OH 45433 USA. RP Yang, C (reprint author), Sigtem Technol Inc, San Mateo, CA 94402 USA. EM chunynag@sigtem.com FU Air Force Research Lab [FA8650-08-C-1407] FX Research supported in part by Air Force Research Lab under Contract No. FA8650-08-C-1407, which is greatly appreciated. We also thank the editor and four anonymous reviewers whose suggestions and comments have improved the focus, quality, and presentation of the paper. NR 39 TC 61 Z9 62 U1 2 U2 8 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0018-9251 J9 IEEE T AERO ELEC SYS JI IEEE Trans. Aerosp. Electron. Syst. PD JUL PY 2012 VL 48 IS 3 BP 2594 EP 2613 DI 10.1109/TAES.2012.6237611 PG 20 WC Engineering, Aerospace; Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA 975ND UT WOS:000306517100047 ER PT J AU Houston, JR Dean, RG AF Houston, James R. Dean, Robert G. TI Comparisons at Tide-Gauge Locations of Glacial Isostatic Adjustment Predictions with Global Positioning System Measurements SO JOURNAL OF COASTAL RESEARCH LA English DT Article DE Sea-level rise; global climate change ID SEA-LEVEL CHANGE; ICE-5G VM2; FENNOSCANDIA; MODEL; RISE; GPS AB Houston, J.R. and Dean, R.G., 2012. Comparisons at tide-gauge locations of glacial isostatic adjustment predictions with global positioning system measurements. Journal of Coastal Research, 28(4), 739-744. West Palm Beach (Florida), ISSN 0749-0208. Glacial isostatic adjustment (GIA) is routinely used to adjust sea-level trends determined from tide-gauge data to improve estimates of worldwide sea-level rise. This adjustment may be appropriate for formerly glaciated high-latitude (referred to as FGHL) areas where vertical land motions due to GIA are large compared with motions produced by other phenomena. However, since GIA is only one component of vertical motion, does adjusting for it outside FGHL areas improve sea-level rise estimates or bias them? We compare global positioning system (GPS) gauge measurements with the vertical land-motion component of GIA predictions at 147 worldwide locations that are near tide gauges and outside FGHL areas and find remarkably little correlation. We analyze the data in several ways to determine the source of the lack of correlation. We also find that the average vertical motion for the 147 locations measured by GPS is subsidence, whereas the average GIA prediction is zero. C1 [Houston, James R.] USA, Corps Engineers, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. [Dean, Robert G.] Univ Florida, Dept Civil & Coastal Engn, Gainesville, FL 32611 USA. RP Houston, JR (reprint author), USA, Corps Engineers, Engineer Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM james.r.houston@usace.army.mil NR 28 TC 11 Z9 11 U1 0 U2 7 PU COASTAL EDUCATION & RESEARCH FOUNDATION PI LAWRENCE PA 810 EAST 10TH STREET, LAWRENCE, KS 66044 USA SN 0749-0208 EI 1551-5036 J9 J COASTAL RES JI J. Coast. Res. PD JUL PY 2012 VL 28 IS 4 BP 739 EP 744 DI 10.2112/JCOASTRES-D-11-00227.1 PG 6 WC Environmental Sciences; Geography, Physical; Geosciences, Multidisciplinary SC Environmental Sciences & Ecology; Physical Geography; Geology GA 974QF UT WOS:000306450700002 ER PT J AU Clark, DV Ismailov, A Seyidova, E Hajiyeva, A Bakhishova, S Hajiyev, H Nuriyev, T Piraliyev, S Bagirov, S Aslanova, A Debes, AK Qasimov, M Hepburn, MJ AF Clark, Danielle V. Ismailov, Afrail Seyidova, Esmiralda Hajiyeva, Ayten Bakhishova, Sevinj Hajiyev, Huseyn Nuriyev, Tahir Piraliyev, Saleh Bagirov, Sadigulla Aslanova, Afag Debes, Amanda K. Qasimov, Maqsud Hepburn, Matthew J. TI Seroprevalence of Tularemia in Rural Azerbaijan SO VECTOR-BORNE AND ZOONOTIC DISEASES LA English DT Article DE Azerbaijan; GIS; seroprevalence; tularemia ID FRANCISELLA-TULARENSIS; MARTHAS-VINEYARD; OUTBREAK; TICKS AB A representative, two-stage probability sampling design was used to select 40 villages in northern Azerbaijan with populations of <500 people to screen for evidence of prior infection with Francisella tularensis. Informed consent was provided, and samples were obtained from 796 volunteers and tested for the presence of immunoglobulin G antibodies using enzyme-linked immunosorbent assay. F. tularensis seropositivity was prevalent (15.5% of volunteers), but there was minimal reporting of signs and symptoms consistent with clinical tularemia, suggesting that mild or asymptomatic infection commonly occurs. Frequently seeing rodents around the home was a risk factor for seropositivity (POR = 1.6, p = 0.03), controlling for age and gender. Geospatial analysis identified associations between village-level tularemia prevalence and suitable tick habitats, annual rainfall, precipitation in the driest quarter, and altitude. This study contributes to the growing understanding of the geographic distribution of tularemia and provides further information on the climatic and landscape conditions that increased the potential for exposure to this pathogen. The potential occurrence of asymptomatic or mild F. tularensis infection warrants further study. C1 [Clark, Danielle V.] Walter Reed Army Inst Res, Silver Spring, MD 20009 USA. [Ismailov, Afrail; Seyidova, Esmiralda; Bakhishova, Sevinj; Hajiyev, Huseyn; Qasimov, Maqsud] Antiplague Stn, Baku, Azerbaijan. [Ismailov, Afrail; Seyidova, Esmiralda; Bakhishova, Sevinj; Hajiyev, Huseyn; Qasimov, Maqsud] Antiplague Stn, Xachmaz, Azerbaijan. [Hajiyeva, Ayten] Republican Vet Lab, Baku, Azerbaijan. [Nuriyev, Tahir; Piraliyev, Saleh; Bagirov, Sadigulla] Ctr Hyg & Epidemiol, Quba, Azerbaijan. [Nuriyev, Tahir; Piraliyev, Saleh; Bagirov, Sadigulla] Ctr Hyg & Epidemiol, Qusar, Azerbaijan. [Nuriyev, Tahir; Piraliyev, Saleh; Bagirov, Sadigulla] Ctr Hyg & Epidemiol, Xachmaz, Azerbaijan. [Aslanova, Afag] Raytheon Tech Serv Co, Baku, Azerbaijan. [Debes, Amanda K.; Hepburn, Matthew J.] USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. RP Clark, DV (reprint author), Walter Reed Army Inst Res, 503 Robert Grant Ave, Silver Spring, MD 20009 USA. EM dvclark@gmail.com FU U.S. Department of Defense Cooperative Threat Reduction Program FX Funding for this project was provided by the U.S. Department of Defense Cooperative Threat Reduction Program, implemented by the U.S. Defense Threat Reduction Agency. NR 27 TC 9 Z9 9 U1 0 U2 2 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1530-3667 J9 VECTOR-BORNE ZOONOT JI Vector-Borne Zoonotic Dis. PD JUL PY 2012 VL 12 IS 7 BP 558 EP 563 DI 10.1089/vbz.2010.0081 PG 6 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA 974YJ UT WOS:000306473200005 PM 22452727 ER PT J AU Summers, RM Liu, JM Sussman, DL Dwyer, AJ Rehani, B Pickhardt, PJ Choi, JR Yao, JH AF Summers, Ronald M. Liu, Jiamin Sussman, Daniel L. Dwyer, Andrew J. Rehani, Bhavya Pickhardt, Perry J. Choi, J. Richard Yao, Jianhua TI Association Between Visceral Adiposity and Colorectal Polyps on CT Colonography SO AMERICAN JOURNAL OF ROENTGENOLOGY LA English DT Article DE colon; colonic polyps; CT; virtual imaging; visceral fat measurement ID BODY-FAT DISTRIBUTION; COLON-CANCER RISK; ADENOMATOUS POLYPS; COMPUTED-TOMOGRAPHY; INSULIN-RESISTANCE; AMERICAN-COLLEGE; RECTAL-CANCER; MASS INDEX; OBESITY; ADIPONECTIN AB OBJECTIVE. The purpose of this article is to determine whether there is an association between visceral adiposity measured on CT colonography (CTC) and colorectal polyps. MATERIALS AND METHODS. Patients who underwent CTC and same-day optical colonoscopy (n = 1186) were analyzed. Visceral adipose tissue volumes and volume percentages relative to total internal body volume were measured on slices in the L2-L3 regions on supine CTC scans with validated fully automated software. Student t test, odds ratio, logistic regression, and receiver operating characteristic analyses were performed. RESULTS. For subjects with (n = 345) and without (n = 841) adenomatous polyps, the mean (+/- SD) volume percentages were 31.2% +/- 10.8% and 28.2% +/- 11.3%, respectively (p < 0.0001). For subjects with (n = 244) and without (n = 942) hyperplastic polyps, the volume percentages were 31.8% +/- 10.7% and 28.3% +/- 11.2%, respectively (p < 0.0001). Comparing the lowest and highest quintiles of volume percentage, the odds ratios for having at least one adenomatous polyp or hyperplastic polyp versus no polyp were 2.06 (95% CI, 1.36-3.13) and 1.71 (95% CI, 1.08-2.71), and the prevalence of having adenomatous polyps or hyperplastic polyps increased by 14% and 8%, respectively. CONCLUSION. Subjects with higher visceral adiposity measurements on CTC have a greater risk for the presence of colonic polyps. C1 [Summers, Ronald M.; Liu, Jiamin; Sussman, Daniel L.; Dwyer, Andrew J.; Rehani, Bhavya; Yao, Jianhua] NIH, Imaging Biomarkers & Comp Aided Diag Lab, Ctr Clin, Bethesda, MD 20892 USA. [Pickhardt, Perry J.] Univ Wisconsin, Dept Radiol, Sch Med, Madison, WI 53706 USA. [Choi, J. Richard] Walter Reed Army Med Ctr, Washington, DC 20307 USA. RP Summers, RM (reprint author), NIH, Imaging Biomarkers & Comp Aided Diag Lab, Ctr Clin, Bldg 10,Rm 1C224D,MSC 1182, Bethesda, MD 20892 USA. EM rms@nih.gov FU Intramural NIH HHS [Z01 CL040003-05, Z01 CL040003-06, ZIA CL040003-07, ZIA CL040003-08, ZIA CL040003-09] NR 50 TC 12 Z9 12 U1 0 U2 5 PU AMER ROENTGEN RAY SOC PI RESTON PA 1891 PRESTON WHITE DR, SUBSCRIPTION FULFILLMENT, RESTON, VA 22091 USA SN 0361-803X J9 AM J ROENTGENOL JI Am. J. Roentgenol. PD JUL PY 2012 VL 199 IS 1 BP 48 EP 57 DI 10.2214/AJR.11.7842 PG 10 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA 965YP UT WOS:000305804000030 PM 22733893 ER PT J AU Merchant-Borna, K Rodrigues, EG Smith, KW Proctor, SP Mcclean, MD AF Merchant-Borna, Kian Rodrigues, Ema G. Smith, Kristen W. Proctor, Susan P. Mcclean, Michael D. TI Characterization of Inhalation Exposure to Jet Fuel among U.S. Air Force Personnel SO ANNALS OF OCCUPATIONAL HYGIENE LA English DT Article DE exposure assessment; hydrocarbons; inhalation; jet fuel; JP-8; mixture ID DERMAL EXPOSURE; JP-8; HYDROCARBONS; NAPHTHALENE; BENZENE; SMOKE; PAHS; SKIN; JP8 AB Jet propulsion fuel-8 (JP-8) is the primary jet fuel used by the US military, collectively consuming similar to 2.5 billion gallons annually. Previous reports suggest that JP-8 is potentially toxic to the immune, respiratory, and nervous systems. The objectives of this study were to evaluate inhalation exposure to JP-8 constituents among active duty United States Air Force (USAF) personnel while performing job-related tasks, identify significant predictors of inhalation exposure to JP-8, and evaluate the extent to which surrogate exposure classifications were predictive of measured JP-8 exposures. Seventy-three full-time USAF personnel from three different air force bases were monitored during four consecutive workdays where personal air samples were collected and analyzed for benzene, ethylbenzene, toluene, xylenes, total hydrocarbons (THC), and naphthalene. The participants were categorized a priori into high- and low-exposure groups, based on their exposure to JP-8 during their typical workday. Additional JP-8 exposure categories included job title groups and self-reported exposure to JP-8. Linear mixed-effects models were used to evaluate predictors of personal air concentrations. The concentrations of THC in air were significantly different between a priori exposure groups (2.6 mg m(-3) in high group versus 0.5 mg m(-3) in low, P < 0.0001), with similar differences observed for other analytes in air. Naphthalene was strongly correlated with THC (r = 0.82, P < 0.0001) and both were positively correlated with the relative humidity of the work environment. Exposures to THC and naphthalene varied significantly by job categories based on USAF specialty codes and were highest among personnel working in fuel distribution/maintenance, though self-reported exposure to JP-8 was an even stronger predictor of measured exposure in models that explained 72% (THC) and 67% (naphthalene) of between-worker variability. In fact, both self-report JP-8 exposure and a priori exposure groups explained more between-worker variability than job categories. Personal exposure to JP-8 varied by job and was positively associated with the relative humidity. However, self-reported exposure to JP-8 was an even stronger predictor of measured exposure than job title categories, suggesting that self-reported JP-8 exposure is a valid surrogate metric of exposure when personal air measurements are not available. C1 [Merchant-Borna, Kian; Rodrigues, Ema G.; Smith, Kristen W.; Proctor, Susan P.; Mcclean, Michael D.] Boston Univ, Sch Publ Hlth, Dept Environm Hlth, Boston, MA 02118 USA. [Merchant-Borna, Kian] Univ Rochester, Dept Environm Med, Sch Med & Dent, Rochester, NY 14642 USA. [Rodrigues, Ema G.; Smith, Kristen W.] Harvard Univ, Dept Environm Hlth, Sch Publ Hlth, Boston, MA 02115 USA. [Proctor, Susan P.] USA, Environm Med Res Inst, Natick, MA 01760 USA. [Proctor, Susan P.] VA Boston Healthcare Syst, Boston, MA 02132 USA. RP Mcclean, MD (reprint author), Boston Univ, Sch Publ Hlth, Dept Environm Hlth, Boston, MA 02118 USA. EM mmcclean@bu.edu RI McClean, Michael/J-2934-2015; OI McClean, Michael/0000-0002-3902-8823 FU US Army Medical Research and Materiel Command [W81XWH-06-1-0105] FX US Army Medical Research and Materiel Command award (W81XWH-06-1-0105) to the Henyt M. Jackson Foundation of the Advancement of Military Medicine, Inc. (PI: SP Proctor). NR 27 TC 4 Z9 4 U1 1 U2 10 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 0003-4878 J9 ANN OCCUP HYG JI Ann. Occup. Hyg. PD JUL PY 2012 VL 56 IS 6 BP 736 EP 745 DI 10.1093/annhyg/mes014 PG 10 WC Public, Environmental & Occupational Health; Toxicology SC Public, Environmental & Occupational Health; Toxicology GA 974DA UT WOS:000306408800009 PM 22433121 ER PT J AU Chung, KK Stewart, IJ Gisler, C Simmons, JW Aden, JK Tilley, MA Cotant, CL White, CE Wolf, SE Renz, EM AF Chung, Kevin K. Stewart, Ian J. Gisler, Christopher Simmons, John W. Aden, James K. Tilley, Molly A. Cotant, Casey L. White, Christopher E. Wolf, Steven E. Renz, Evan M. TI The Acute Kidney Injury Network (AKIN) Criteria Applied in Burns SO JOURNAL OF BURN CARE & RESEARCH LA English DT Article ID ACUTE-RENAL-FAILURE; INTENSIVE-CARE-UNIT; MORTALITY; RIFLE; DYSFUNCTION; DEFINITION; COHORT AB In 2007, the Acute Kidney Injury Network (AKIN) developed a modified standard for diagnosing and classifying acute kidney injury (AKI). This classification system is a modification of the previously described risk, injury, failure, loss, and end-stage (RIFLE) criteria. Among other modifications, the AKIN staging requires an absolute serum creatinine change of 0.3 mg/dl in a 48-hour period to establish the diagnosis of AKI. The purpose of this study was to apply these new criteria in the severely burned population and to compare the prevalence, stage, and mortality impact of these criteria to the RIFLE criteria. The authors performed a retrospective analysis of consecutive patients with burns admitted to their burn center for at least 24 hours from June 2003 through December 2008. Each patient was classified by both the AKIN and RIFLE criteria by three referees. Both univariate and multivariate analyses were performed to determine the impact of the various AKI stages on mortality. A total of 1973 patients met inclusion and exclusion criteria and were included in the analysis. The average age, % TBSA, injury severity score, and percent with smoke inhalation injury were 36 +/- 16, 16 +/- 18, 10 +/- 12, and 13%, respectively. Overall, the prevalence of AKI was 33% using the AKIN criteria and 24% using the RIFLE criteria with an associated mortality of 21 and 25%, respectively. Of those meeting criteria for AKIN stage 1 (N = 434), 41% (N = 180) would have been categorized as not having AKI on the basis of the RIFLE criteria. In this cohort of patients, mortality increased by almost 8-fold when compared with those without AKI (odds ratio 7.8 [95% confidence interval (CI) 3.7-16.2], P < .0001). The area under the receiver operator characteristic curve for in-hospital mortality was significantly higher for the AKIN criteria at 0.877 (95% CI 0.848-0.906) when compared to the RIFLE criteria at 0.838 (95% CI 0.801-0.874; P = .0007). Burn patients indentified as having AKI by the AKIN criteria missed by RIFLE appear to be an important cohort. On the basis of our study, AKIN criteria may be more precise and are more predictive of death than the RIFLE criteria in this population. Prospective validation is needed. (J Burn Care Res 2012;33:483-490) C1 [Chung, Kevin K.; Aden, James K.; White, Christopher E.; Renz, Evan M.] USA, Inst Surg Res, Clin Div, Ft Sam Houston, TX 78234 USA. [Stewart, Ian J.; Tilley, Molly A.; Cotant, Casey L.] San Antonio Mil Med Ctr, Dept Nephrol, Ft Sam Houston, TX USA. [Stewart, Ian J.; Gisler, Christopher] Univ Texas Hlth Sci Ctr San Antonio, Dept Nephrol, San Antonio, TX 78229 USA. [Simmons, John W.] San Antonio Mil Med Ctr, Dept Surg, Ft Sam Houston, TX USA. [Wolf, Steven E.] Univ Texas SW, Dept Surg, Dallas, TX USA. [Renz, Evan M.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. RP Chung, KK (reprint author), USA, Inst Surg Res, 3400 Rawley E Chambers Ave, San Antonio, TX 78234 USA. OI Wolf, Steven/0000-0003-2972-3440 FU Clinical Trials Task Area, United States Army Institute of Surgical Research FX This project was funded by the Clinical Trials Task Area, United States Army Institute of Surgical Research. NR 18 TC 21 Z9 21 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1559-047X J9 J BURN CARE RES JI J. Burn Care Res. PD JUL-AUG PY 2012 VL 33 IS 4 BP 483 EP 490 DI 10.1097/BCR.0b013e31825aea8d PG 8 WC Emergency Medicine; Dermatology; Surgery SC Emergency Medicine; Dermatology; Surgery GA 972KC UT WOS:000306275000015 PM 22688091 ER PT J AU Hardin, MO Mace, JE Ritchie, JD Chung, KK Markell, KW Renz, EM Wolf, SE Blackbourne, LH White, CE AF Hardin, Mark O. Mace, James E. Ritchie, John D. Chung, Kevin K. Markell, Katharine W. Renz, Evan M. Wolf, Steven E. Blackbourne, Lorne H. White, Christopher E. TI An Experience in the Management of the Open Abdomen in Severely Injured Burn Patients SO JOURNAL OF BURN CARE & RESEARCH LA English DT Article; Proceedings Paper CT 41st Annual Meeting of the American-Burn-Association CY MAR 24-27, 2009 CL San Antonio, TX SP Amer Burn Assoc ID ABDOMINAL COMPARTMENT SYNDROME; OPERATION IRAQI FREEDOM; FASCIAL CLOSURE; TRAUMA PATIENTS AB Few descriptions of temporary abdominal closure for planned relaparotomy have been reported in burned patients. The purpose of this study is to describe our experience and outcomes in the management of burned patients with an open abdomen. The authors performed a retrospective review of all admissions to our burn center from March 2003 to June 2008, identifying patients treated by laparotomy with temporary abdominal closure. The authors collected data on patient demographics, indication for laparotomy, methods of temporary and definitive abdominal closure, and outcomes. Of 2,104 patients admitted, 38 underwent a laparotomy with temporary abdominal closure. Their median TBSA was 55%, and the incidence of inhalation injury was 58%. Abdominal compartment syndrome was the most common indication for laparotomy (82%) followed by abdominal trauma (16%). The in-hospital mortality associated with an open abdomen was 68%. Temporary abdominal closure was performed most commonly using negative pressure wound therapy (90%). Fascial closure was performed in 21 patients but was associated with a 38% rate of failure requiring reexploration. Of 12 survivors, fascial closure was achieved in seven patients and five were managed with a planned ventral hernia. Burned patients who necessitate an open abdomen management strategy have a high morbidity and mortality. Fascial closure was associated with a high rate of failure but was successful in a select group of patients. Definitive abdominal closure with a planned ventral hernia was associated with no increased mortality and remains an option when "tension-free" fascial closure cannot be achieved. (J Burn Care Res 2012;33:491-496) C1 [Hardin, Mark O.; Mace, James E.; Ritchie, John D.; Chung, Kevin K.; Markell, Katharine W.; Renz, Evan M.; Wolf, Steven E.; Blackbourne, Lorne H.; White, Christopher E.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP White, CE (reprint author), USA, Inst Surg Res, 3400 Rawley E Chambers Ave, Ft Sam Houston, TX 78234 USA. OI Wolf, Steven/0000-0003-2972-3440 NR 21 TC 3 Z9 4 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1559-047X J9 J BURN CARE RES JI J. Burn Care Res. PD JUL-AUG PY 2012 VL 33 IS 4 BP 491 EP 496 DI 10.1097/BCR.0b013e3182479b00 PG 6 WC Emergency Medicine; Dermatology; Surgery SC Emergency Medicine; Dermatology; Surgery GA 972KC UT WOS:000306275000016 PM 22777397 ER PT J AU Oh, JS Chung, KK Allen, A Batchinsky, AI Huzar, T King, BT Wolf, SE Sjulin, T Cancio, LC AF Oh, John S. Chung, Kevin K. Allen, Anthony Batchinsky, Andriy I. Huzar, Todd King, Booker T. Wolf, Steven E. Sjulin, Tyson Cancio, Leopoldo C. TI Admission Chest CT Complements Fiberoptic Bronchoscopy in Prediction of Adverse Outcomes in Thermally Injured Patients SO JOURNAL OF BURN CARE & RESEARCH LA English DT Article ID RESPIRATORY-DISTRESS-SYNDROME; SMOKE-INHALATION INJURY; FREQUENCY PERCUSSIVE VENTILATION; COMPUTED TOMOGRAPHIC SCANS; EARLY-DIAGNOSIS; LUNG INJURY; BURN; MANIFESTATIONS; RESUSCITATION; PNEUMONIA AB In burned patients, inhalation injury can result in progressive pulmonary dysfunction, infection, and death. Although bronchoscopy is the standard for diagnosis, it only assesses the proximal airway and does not provide a comprehensive analysis of pulmonary insult. Chest radiographs have not been proven helpful in diagnosis of inhalation injury. Our hypothesis is that a CT scan alone or in conjunction with bronchoscopy can be used as a prognostic tool for critically ill burn patients, especially those with inhalation injury. The authors performed a retrospective study of all patients admitted to the U. S. Army Institute of Surgical Research Burn Center between 2002 and 2008 with chest CT within 24 hours of admission. They divided subjects into two groups, those with evidence of inhalation injury on bronchoscopy and those without. They used a radiologist's score to assess the degree of damage to the pulmonary parenchyma. The primary endpoint was a composite of pneumonia, acute lung injury/acute respiratory distress syndrome, and death. The inhalation injury group consisted of 25 patients and the noninhalation injury group of 19 patients. Groups were not different in age, TBSA burned, and percentage full-thickness burn. By multiple logistic regression, detection of inhalation injury on bronchoscopy was associated with an 8.3-fold increase in the composite endpoint. The combination of inhalation injury on bronchoscopy and a high radiologist's score was associated with a 12.7-fold increase in the incidence of the composite endpoint. Admission CT assists in predicting future lung dysfunction in burn patients. (J Burn Care Res 2012;33:532-538) C1 [Oh, John S.; Chung, Kevin K.; Allen, Anthony; Batchinsky, Andriy I.; Huzar, Todd; King, Booker T.; Wolf, Steven E.; Sjulin, Tyson; Cancio, Leopoldo C.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Oh, JS (reprint author), MCEUL TP, Landstuhl Reg Med Ctr, Dept Surg, CMR 402,APO AE 09180, Landstuhl, Rhineland Palat, Germany. OI Wolf, Steven/0000-0003-2972-3440 NR 36 TC 12 Z9 12 U1 0 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1559-047X J9 J BURN CARE RES JI J. Burn Care Res. PD JUL-AUG PY 2012 VL 33 IS 4 BP 532 EP 538 DI 10.1097/BCR.0b013e318237455f PG 7 WC Emergency Medicine; Dermatology; Surgery SC Emergency Medicine; Dermatology; Surgery GA 972KC UT WOS:000306275000022 PM 22210063 ER PT J AU Arun, P Abu-Taleb, R Valiyaveettil, M Wang, Y Long, J Nambiar, M AF Arun, Peethambaran Abu-Taleb, Rania Valiyaveettil, Manojkumar Wang, Ying Long, Joseph Nambiar, Madhusoodana TI TRANSIENT MEMBRANE DISRUPTION AFTER BLAST EXPOSURE AND PHARMACOLOGICAL INTERVENTIONS FOR PROTECTION SO JOURNAL OF NEUROTRAUMA LA English DT Meeting Abstract CT 30th Annual National Neurotrauma Symposium CY JUL 22-25, 2012 CL Phoenix, AZ DE Blast TBI; membrane disruption; CDP-choline C1 [Arun, Peethambaran; Abu-Taleb, Rania; Valiyaveettil, Manojkumar; Wang, Ying; Long, Joseph; Nambiar, Madhusoodana] Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 J9 J NEUROTRAUM JI J. Neurotrauma PD JUL PY 2012 VL 29 IS 10 BP A217 EP A218 PG 2 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA 971YV UT WOS:000306244400379 ER PT J AU Boutte, AM Yu, CG Yu, XP Dutta, B Feala, J Schmid, K Dave, J Tortella, FC Reifman, J AF Boutte, Angela M. Yu, Chenggang Yu, Xueping Dutta, Bhaskar Feala, Jacob Schmid, Kara Dave, Jitendra Tortella, Frank C. Reifman, Jaques TI SYSTEMS BIOLOGY META-ANALYSES OF GENOMIC DATASETS TO IDENTIFY CONSERVED MECHANISMS AND NOVEL BIOMARKERS OF TRAUMATIC BRAIN INJURY SO JOURNAL OF NEUROTRAUMA LA English DT Meeting Abstract CT 30th Annual National Neurotrauma Symposium CY JUL 22-25, 2012 CL Phoenix, AZ DE Brain Injury; Biomarker; Systems Biology C1 [Boutte, Angela M.] Walter Reed Army Inst Res, Brain Trauma Neuroprotect & Neurorestorat Branch, Silver Spring, MD USA. [Yu, Chenggang; Yu, Xueping; Dutta, Bhaskar; Feala, Jacob; Reifman, Jaques] USA, Med Res & Mat Command, BHSAI MRMC, DoD Biotechnol HPC Software Applicat Inst, Washington, DC USA. RI Dave, Jitendra/A-8940-2011 NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 J9 J NEUROTRAUM JI J. Neurotrauma PD JUL PY 2012 VL 29 IS 10 BP A102 EP A103 PG 2 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA 971YV UT WOS:000306244400173 ER PT J AU Boutte, AM Tong, M Pedersen, R Shaughness, M Maudlin-Jeronimo, E Maj, KS Genovese, R Ahlers, S Tortella, FC Dave, J AF Boutte, Angela M. Tong, Min Pedersen, Rebecca Shaughness, Michael Maudlin-Jeronimo, Eric Maj, Kara Schmid Genovese, Raymond Ahlers, Stephen Tortella, Frank C. Dave, Jitendra TI DIFFERENTIAL PROTEIN CHANGES IN PENETRATING AND NON-PENETRATING MODELS OF TBI SO JOURNAL OF NEUROTRAUMA LA English DT Meeting Abstract CT 30th Annual National Neurotrauma Symposium CY JUL 22-25, 2012 CL Phoenix, AZ DE traumatic brain injury; biomarker; spectrin C1 [Boutte, Angela M.] Walter Reed Army Inst Res, Brain Trauma Neuroprotect & Neurorestorat Branch, Silver Spring, MD USA. RI Dave, Jitendra/A-8940-2011 NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 J9 J NEUROTRAUM JI J. Neurotrauma PD JUL PY 2012 VL 29 IS 10 BP A51 EP A52 PG 2 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA 971YV UT WOS:000306244400084 ER PT J AU Cartagena, C Phillips, K Sanders, V Schmid, K Tortella, FC Dave, JR AF Cartagena, Casandra Phillips, Katie Sanders, Valeta Schmid, Kara Tortella, Frank C. Dave, Jitendra R. TI TEMPORAL ALTERATIONS IN HIF1-ALPHA AND AQUAPORIN EXPRESSION FOLLOWING PBBI SO JOURNAL OF NEUROTRAUMA LA English DT Meeting Abstract CT 30th Annual National Neurotrauma Symposium CY JUL 22-25, 2012 CL Phoenix, AZ DE TBI; PBBI; Hypoxia; Edema C1 [Cartagena, Casandra; Phillips, Katie; Sanders, Valeta; Schmid, Kara; Tortella, Frank C.; Dave, Jitendra R.] Walter Reed Army Inst Res, Silver Spring, MD USA. RI Dave, Jitendra/A-8940-2011 NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 J9 J NEUROTRAUM JI J. Neurotrauma PD JUL PY 2012 VL 29 IS 10 BP A71 EP A71 PG 1 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA 971YV UT WOS:000306244400118 ER PT J AU Chen, ZY Dave, J Liao, ZL Lu, XCM Tortella, F Shear, DA AF Chen, Zhiyong Dave, Jitendra Liao, Zhiling Lu, X-C May Tortella, Frank Shear, Deborah A. TI AMNION DERIVED MULTIPOTENT CELLS INHIBIT LIPOPOLYSACCHARIDE-INDUCED MICROGLIA ACTIVATION IN VITRO VIA CELL-CELL CONTACT SO JOURNAL OF NEUROTRAUMA LA English DT Meeting Abstract CT 30th Annual National Neurotrauma Symposium CY JUL 22-25, 2012 CL Phoenix, AZ DE Amnion Derived Multipotent Cells; microglia C1 [Lu, X-C May] Stemnion Inc, Stemnion Inc NA, Walter Reed Army Inst Res, Silver Spring, MD USA. [Tortella, Frank] WRAIR, Ctr Excellence Psychiat & Neurosci, Brain Trauma Neuroprotect & Neurorestorat Branch, Silver Spring, MD USA. RI Shear, Deborah/B-3607-2011; Dave, Jitendra/A-8940-2011 NR 0 TC 0 Z9 0 U1 0 U2 1 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 J9 J NEUROTRAUM JI J. Neurotrauma PD JUL PY 2012 VL 29 IS 10 BP A176 EP A177 PG 2 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA 971YV UT WOS:000306244400305 ER PT J AU Cunningham, TL Cartagena, C Shear, DA Lu, XCM Kolpoko, M Dave, J Tortella, FC AF Cunningham, Tracy L. Cartagena, Casandra Shear, Deborah A. Lu, Xi-Chun M. Kolpoko, Melissa Dave, Jitendra Tortella, Frank C. TI COMPARISON OF THE BLOOD-BRAIN BARRIER DISRUPTION TIMELINE AND NEUROINFLAMMATION POST-PENETRATING BALLISTIC-LIKE BRAIN INJURY IN RATS SO JOURNAL OF NEUROTRAUMA LA English DT Meeting Abstract CT 30th Annual National Neurotrauma Symposium CY JUL 22-25, 2012 CL Phoenix, AZ DE PBBI; Neuroinflammation; Blood-brain barrier; TBI C1 [Cunningham, Tracy L.; Cartagena, Casandra; Shear, Deborah A.; Lu, Xi-Chun M.; Kolpoko, Melissa; Dave, Jitendra; Tortella, Frank C.] Walter Reed Army Inst Res, Silver Spring, MD USA. RI Shear, Deborah/B-3607-2011; Dave, Jitendra/A-8940-2011 NR 0 TC 0 Z9 0 U1 0 U2 2 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 J9 J NEUROTRAUM JI J. Neurotrauma PD JUL PY 2012 VL 29 IS 10 BP A122 EP A122 PG 1 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA 971YV UT WOS:000306244400207 ER PT J AU Deng-Bryant, Y van der Merwe, C Bustos, F Yang, WH Chen, ZY Shear, DA Tortella, FC AF Deng-Bryant, Ying van der Merwe, Christopher Bustos, Francis Yang, Weihong Chen, Zhiyong Shear, Deborah A. Tortella, Frank C. TI COMPARISON OF INTRAVENOUS AND INTRACEREBROVENTRICULAR ADMINISTRATION OF AMNION-DERIVED CELLULAR CYTOKINE SOLUTION IN A RAT MODEL OF PENETRATING BALLISTIC-LIKE BRAIN INJURY SO JOURNAL OF NEUROTRAUMA LA English DT Meeting Abstract CT 30th Annual National Neurotrauma Symposium CY JUL 22-25, 2012 CL Phoenix, AZ DE Amnion-derived Cellular Cytokine Solution C1 [Deng-Bryant, Ying; van der Merwe, Christopher; Bustos, Francis; Yang, Weihong; Chen, Zhiyong; Shear, Deborah A.; Tortella, Frank C.] Walter Reed Army Inst Res, Silver Spring, MD USA. RI Shear, Deborah/B-3607-2011 NR 0 TC 0 Z9 0 U1 0 U2 1 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 J9 J NEUROTRAUM JI J. Neurotrauma PD JUL PY 2012 VL 29 IS 10 BP A171 EP A172 PG 2 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA 971YV UT WOS:000306244400296 ER PT J AU Jackson, C Yokobori, S Gajavelli, S Bomberger, C Zeidan, M Leung, LY Tortella, FC Bullock, MR AF Jackson, Clayton Yokobori, Shoji Gajavelli, Shyam Bomberger, Christine Zeidan, Michelle Leung, Lai Yee Tortella, Frank C. Bullock, M. Ross TI PERFLUOROCARBON EMULSION IMPROVES CEREBRAL TISSUE OXYGENATION AFTER PENETRATING BALLISTIC-LIKE BRAIN INJURY IN RAT SO JOURNAL OF NEUROTRAUMA LA English DT Meeting Abstract CT 30th Annual National Neurotrauma Symposium CY JUL 22-25, 2012 CL Phoenix, AZ DE TBI; PBBI; PbtO2; perfluorocarbon; neuroprotection C1 [Jackson, Clayton; Yokobori, Shoji; Gajavelli, Shyam; Bullock, M. Ross] Univ Miami, Sch Med, Miami Project Cure Paralysis, Dept Neurosurg, Coral Gables, FL 33124 USA. [Leung, Lai Yee; Tortella, Frank C.] Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 J9 J NEUROTRAUM JI J. Neurotrauma PD JUL PY 2012 VL 29 IS 10 BP A214 EP A214 PG 1 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA 971YV UT WOS:000306244400372 ER PT J AU Kochanek, PM Bramlett, H Dixon, CE Shear, DA Mondello, S Schmid, K Dietrich, WD Wang, K Hayes, R Tortella, FC AF Kochanek, Patrick M. Bramlett, Helen Dixon, C. Edward Shear, Deborah A. Mondello, Stefania Schmid, Kara Dietrich, W. Dalton Wang, Kevin Hayes, Ronald Tortella, Frank C. TI CROSS MODEL COMPARISON OF BEHAVIOR, NEUROPATHOLOGY, AND SERUM BIOMARKERS AFTER CONTROLLED CORTICAL IMPACT, PARASAGITTAL FLUID PERCUSSION, AND PENETRATING BALLISTIC-LIKE BRAIN INJURY: RESULTS FROM OPERATION BRAIN TRAUMA THERAPY SO JOURNAL OF NEUROTRAUMA LA English DT Meeting Abstract CT 30th Annual National Neurotrauma Symposium CY JUL 22-25, 2012 CL Phoenix, AZ DE traumatic brain injury; neuroprotection; consortium C1 [Kochanek, Patrick M.; Dixon, C. Edward] Univ Pittsburgh, Sch Med, Safar Ctr Resuscitat Res, Pittsburgh, PA 15260 USA. [Dietrich, W. Dalton] Univ Miami, Miller Sch Med, Miami Project Cure Paralysis, Dept Neurol Surg, Coral Gables, FL 33124 USA. [Shear, Deborah A.; Schmid, Kara; Tortella, Frank C.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Wang, Kevin] Univ Florida, Dept Psychiat, Gainesville, FL 32611 USA. RI Mondello, Stefania/A-1813-2012; Shear, Deborah/B-3607-2011; Kochanek, Patrick/D-2371-2015 OI Mondello, Stefania/0000-0002-8587-3614; Kochanek, Patrick/0000-0002-2627-913X NR 0 TC 0 Z9 0 U1 0 U2 3 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 J9 J NEUROTRAUM JI J. Neurotrauma PD JUL PY 2012 VL 29 IS 10 BP A23 EP A23 PG 1 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA 971YV UT WOS:000306244400035 ER PT J AU Leung, LY McLoughlin, S Wei, G Shear, DA Tortella, F AF Leung, Lai Yee McLoughlin, Shawn Wei, Guo Shear, Deborah A. Tortella, Frank TI TEMPORAL AND SPATIAL PROFILE OF HISTOPATHOLOGICAL CHANGES CAUSED BY HEMORRHAGIC SHOCK AFTER PENETRATING BALLISTIC-LIKE BRAIN INJURY (PBBI) SO JOURNAL OF NEUROTRAUMA LA English DT Meeting Abstract CT 30th Annual National Neurotrauma Symposium CY JUL 22-25, 2012 CL Phoenix, AZ DE Polytrauma; PBBI; Hemorrhagic Shock; Histopathology C1 [Tortella, Frank] Walter Reed Army Inst Res, Ctr Excellence Psychiat & Neurosci, Brain Trauma Neuroprotect & Neurorestorat Branch, Silver Spring, MD USA. RI Shear, Deborah/B-3607-2011 NR 0 TC 0 Z9 0 U1 0 U2 1 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 J9 J NEUROTRAUM JI J. Neurotrauma PD JUL PY 2012 VL 29 IS 10 BP A218 EP A218 PG 1 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA 971YV UT WOS:000306244400380 ER PT J AU Leung, LY Larimore, Z Holmes, L McLoughlin, S Mountney, A Schmid, K Shear, DA Tortella, F AF Leung, Lai Yee Larimore, Zachary Holmes, Larry McLoughlin, Shawn Mountney, Andrea Schmid, Kara Shear, Deborah A. Tortella, Frank TI WRAIR PROJECTILE CONCUSSIVE IMPACT (PCI) MODEL: INJURY DEVICE AND HELMET ADVANCED DEVELOPMENT SO JOURNAL OF NEUROTRAUMA LA English DT Meeting Abstract CT 30th Annual National Neurotrauma Symposium CY JUL 22-25, 2012 CL Phoenix, AZ DE mTBI; Concussion; Injury Device; Helmet C1 [Tortella, Frank] Walter Reed Army Inst Res, Brain Trauma Neuroprotect & Neurorestorat Branch, Ctr Excellence Psychiat & Neurosci, Silver Spring, MD USA. [Larimore, Zachary; Holmes, Larry] USA, Res Lab, Adelphi, MD USA. RI Shear, Deborah/B-3607-2011 NR 0 TC 0 Z9 0 U1 0 U2 4 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 J9 J NEUROTRAUM JI J. Neurotrauma PD JUL PY 2012 VL 29 IS 10 BP A72 EP A72 PG 1 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA 971YV UT WOS:000306244400119 ER PT J AU Lu, XCM Mountney, A Chen, ZY Wei, G Cao, Y Leung, LY Khatri, V Cunningham, T Harris, J Tortella, FC AF Lu, Xi-Chun M. Mountney, Andrea Chen, Zhiyong Wei, Guo Cao, Ying Leung, Lai Yee Khatri, Vivek Cunningham, Tracy Harris, Jesse Tortella, Frank C. TI SIMILARITIES AND DIFFERENCES OF ACUTE EPILEPTIC ACTIVITIES FOLLOWING PENETRATING BALLISTIC-LIKE BRAIN INJURY AND FOCAL BRAIN ISCHEMIA IN RATS SO JOURNAL OF NEUROTRAUMA LA English DT Meeting Abstract CT 30th Annual National Neurotrauma Symposium CY JUL 22-25, 2012 CL Phoenix, AZ DE PBBI; Nonconvulsive seizure; EEG; Rat C1 [Lu, Xi-Chun M.; Mountney, Andrea; Chen, Zhiyong; Wei, Guo; Cao, Ying; Leung, Lai Yee; Khatri, Vivek; Cunningham, Tracy; Harris, Jesse; Tortella, Frank C.] Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 J9 J NEUROTRAUM JI J. Neurotrauma PD JUL PY 2012 VL 29 IS 10 BP A172 EP A172 PG 1 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA 971YV UT WOS:000306244400297 ER PT J AU Lu, XCM Graham, PB Cao, Y Harris, J Shear, D Schmid, K Tortella, FC AF Lu, Xi-Chun M. Graham, Philip B. Cao, Ying Harris, Jessie Shear, Deborah Schmid, Kara Tortella, Frank C. TI DOSE-RESPONSE EFFECTS OF C-10068 ON ATTENUATION OF NONCONVULSIVE SEIZURES INDUCED BY PENETRATING BALLISTIC-LIKE BRAIN INJURY IN RATS SO JOURNAL OF NEUROTRAUMA LA English DT Meeting Abstract CT 30th Annual National Neurotrauma Symposium CY JUL 22-25, 2012 CL Phoenix, AZ DE PBBI; nonconvulsive seizures; EEG; C-10068 C1 [Lu, Xi-Chun M.; Cao, Ying; Harris, Jessie; Shear, Deborah; Schmid, Kara; Tortella, Frank C.] Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 J9 J NEUROTRAUM JI J. Neurotrauma PD JUL PY 2012 VL 29 IS 10 BP A122 EP A123 PG 2 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA 971YV UT WOS:000306244400208 ER PT J AU Mondello, S Yang, BX Zoltewicz, S Gabrielli, A Catani, S Mo-Seany, J Schmid, K Tortella, FC Wang, KKW Hayes, R Formisano, R AF Mondello, Stefania Yang, Boxuan Zoltewicz, Susie Gabrielli, Andrea Catani, Sheila Mo-Seany, Jixiang Schmid, Kara Tortella, Frank C. Wang, Kevin K. W. Hayes, Ronald Formisano, Rita TI PERSISTENT VEGETATIVE STATE FOLLOWING SEVERE TRAUMATIC BRAIN INJURY IS ASSOCIATED WITH BRAIN-REACTIVE ANTIBODIES IN SERUM SO JOURNAL OF NEUROTRAUMA LA English DT Meeting Abstract CT 30th Annual National Neurotrauma Symposium CY JUL 22-25, 2012 CL Phoenix, AZ DE Biomarkers; TBI; Persistent Vegetative State C1 [Gabrielli, Andrea; Wang, Kevin K. W.] Univ Florida, Gainesville, FL 32611 USA. [Schmid, Kara; Tortella, Frank C.] Walter Reed Army Inst Res, Silver Spring, MD USA. RI Mondello, Stefania/A-1813-2012 OI Mondello, Stefania/0000-0002-8587-3614 NR 0 TC 0 Z9 0 U1 0 U2 6 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 J9 J NEUROTRAUM JI J. Neurotrauma PD JUL PY 2012 VL 29 IS 10 BP A134 EP A134 PG 1 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA 971YV UT WOS:000306244400229 ER PT J AU Mondello, S Bramlett, HM Dixon, CE Shear, DA Zhang, ZQ Zoltewicz, S Schmid, K Dietrich, WD Wang, KKW Hayes, R Tortella, FC Kochanek, PM AF Mondello, Stefania Bramlett, Helen M. Dixon, C. Edward Shear, Deborah A. Zhang, Zhiqun Zoltewicz, Susie Schmid, Kara Dietrich, W. Dalton Wang, Kevin K. W. Hayes, Ronald Tortella, Frank C. Kochanek, Patrick M. TI DIFFERENTIAL EFFECT OF NICOTINAMIDE ON SERUM DAMAGE MARKER PROFILES FOLLOWING CONTROLLED CORTICAL IMPACT, PARASAGITTAL FLUID PERCUSSION, AND PENETRATING BALLISTIC-LIKE BRAIN INJURY: RESULTS FROM OPERATION BRAIN TRAUMA THERAPY SO JOURNAL OF NEUROTRAUMA LA English DT Meeting Abstract CT 30th Annual National Neurotrauma Symposium CY JUL 22-25, 2012 CL Phoenix, AZ DE TBI; Biomarker; Neuroprotection; Rat; Model C1 [Bramlett, Helen M.] Univ Miami, Miller Sch Med, Dept Neurosurg, Miami Project Cure Paralysis, Coral Gables, FL 33124 USA. [Dixon, C. Edward; Kochanek, Patrick M.] Univ Pittsburgh, Sch Med, Safar Ctr Resuscitat Res, Pittsburgh, PA 15260 USA. [Shear, Deborah A.; Schmid, Kara; Tortella, Frank C.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Wang, Kevin K. W.] Univ Florida, Gainesville, FL 32611 USA. [Dietrich, W. Dalton] Univ Miami, Miller Sch Med, Miami Project Cure Paralysis, Dept Neurol Surg, Coral Gables, FL 33124 USA. RI Mondello, Stefania/A-1813-2012; Shear, Deborah/B-3607-2011; Kochanek, Patrick/D-2371-2015 OI Mondello, Stefania/0000-0002-8587-3614; Kochanek, Patrick/0000-0002-2627-913X NR 0 TC 0 Z9 0 U1 0 U2 3 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 J9 J NEUROTRAUM JI J. Neurotrauma PD JUL PY 2012 VL 29 IS 10 BP A48 EP A48 PG 1 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA 971YV UT WOS:000306244400078 ER PT J AU Mountney, A Leung, LY Pedersen, R Shear, DA Tortella, FC AF Mountney, Andrea Leung, Lai Yee Pedersen, Rebecca Shear, Deborah A. Tortella, Frank C. TI LONGITUDINAL PROFILE OF GAIT DISTURBANCES FOLLOWING PENETRATING BALLISTIC-LIKE BRAIN INJURY USING THE CatWalk GAIT ANALYSIS SYSTEM SO JOURNAL OF NEUROTRAUMA LA English DT Meeting Abstract CT 30th Annual National Neurotrauma Symposium CY JUL 22-25, 2012 CL Phoenix, AZ DE TBI; gait; Catwalk C1 [Mountney, Andrea; Leung, Lai Yee; Pedersen, Rebecca; Shear, Deborah A.; Tortella, Frank C.] Walter Reed Army Inst Res, Silver Spring, MD USA. RI Shear, Deborah/B-3607-2011 NR 0 TC 0 Z9 0 U1 0 U2 1 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 J9 J NEUROTRAUM JI J. Neurotrauma PD JUL PY 2012 VL 29 IS 10 BP A219 EP A219 PG 1 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA 971YV UT WOS:000306244400381 ER PT J AU Mountney, A Lu, XCM Yang, WH Cao, Y Shear, DA Tortella, FC AF Mountney, Andrea Lu, Xi-Chun M. Yang, Weihong Cao, Ying Shear, Deborah A. Tortella, Frank C. TI ETHOSUXIMIDE DOSE-DEPENDENTLY ATTENUATED NONCONVULSIVE SEIZURES INDUCED BY PENETRATING BALLISTIC-LIKE BRAIN INJURY IN RATS SO JOURNAL OF NEUROTRAUMA LA English DT Meeting Abstract CT 30th Annual National Neurotrauma Symposium CY JUL 22-25, 2012 CL Phoenix, AZ DE TBI; EEG; nonconvulsive seizure; Ethosuximide C1 [Mountney, Andrea; Lu, Xi-Chun M.; Yang, Weihong; Cao, Ying; Shear, Deborah A.; Tortella, Frank C.] Walter Reed Army Inst Res, Silver Spring, MD USA. RI Shear, Deborah/B-3607-2011 NR 0 TC 0 Z9 0 U1 0 U2 1 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 J9 J NEUROTRAUM JI J. Neurotrauma PD JUL PY 2012 VL 29 IS 10 BP A11 EP A12 PG 2 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA 971YV UT WOS:000306244400017 ER PT J AU Papa, L Wang, KKW Brophy, GM Demery, J Silvestri, S Giordano, P Falk, J Schmid, K Tortella, FC Hayes, R Robertson, C AF Papa, Linda Wang, Kevin K. W. Brophy, Gretchen M. Demery, Jason Silvestri, Salvatore Giordano, Philip Falk, Jay Schmid, Kara Tortella, Frank C. Hayes, Ronald Robertson, Claudia TI SERUM LEVELS OF SPECTRIN BREAKDOWN PRODUCT 150 (SBDP150) DISTINGUISH MILD TRAUMATIC BRAIN INJURY FROM TRAUMA AND UNINJURED CONTROLS AND PREDICT INTRACRANIAL INJURIES ON CT AND NEUROSURGICAL INTERVENTION SO JOURNAL OF NEUROTRAUMA LA English DT Meeting Abstract CT 30th Annual National Neurotrauma Symposium CY JUL 22-25, 2012 CL Phoenix, AZ DE Serum; biomarker; neuronal; TBI; neuroimaging C1 [Wang, Kevin K. W.] Univ Florida, McKnight Brain Inst, Gainesville, FL 32611 USA. [Brophy, Gretchen M.] Virginia Commonwealth Univ, Med Coll Virginia, Richmond, VA 23284 USA. [Schmid, Kara; Tortella, Frank C.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Robertson, Claudia] Baylor Coll Med, Houston, TX 77030 USA. NR 0 TC 1 Z9 1 U1 0 U2 0 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 J9 J NEUROTRAUM JI J. Neurotrauma PD JUL PY 2012 VL 29 IS 10 BP A39 EP A40 PG 2 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA 971YV UT WOS:000306244400064 ER PT J AU Prima, V Scharf, D Gutierrez, H Kirk, D Svetlov, A Curley, K Hayes, R Svetlov, S AF Prima, Victor Scharf, Dancia Gutierrez, Hector Kirk, Daniel Svetlov, Artem Curley, Kenneth Hayes, Ronald Svetlov, Stanislav TI MULTIPLE BLAST EXPOSURES EXACERBATE SYSTEMIC LEAKAGE OF NEURO-GLIAL BIOMARKERS IN A RAT MODEL OF BLAST INJURY SO JOURNAL OF NEUROTRAUMA LA English DT Meeting Abstract CT 30th Annual National Neurotrauma Symposium CY JUL 22-25, 2012 CL Phoenix, AZ DE Blast; TBI; Neuro-glial; Biomarkers; Circulation C1 [Prima, Victor; Scharf, Dancia; Svetlov, Artem; Hayes, Ronald; Svetlov, Stanislav] Banyan Biomarkers Inc, Alachua, FL USA. [Gutierrez, Hector; Kirk, Daniel] Florida Inst Technol, Melbourne, FL USA. [Curley, Kenneth] USA, Med Res & Mat Command, Washington, DC USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 J9 J NEUROTRAUM JI J. Neurotrauma PD JUL PY 2012 VL 29 IS 10 BP A47 EP A48 PG 2 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA 971YV UT WOS:000306244400077 ER PT J AU Shear, DA Mountney, A Pedersen, R Sun, J Long, M Lu, XCM Tortella, FC AF Shear, Deborah A. Mountney, Andrea Pedersen, Rebecca Sun, Justin Long, Melissa Lu, Xi-Chun M. Tortella, Frank C. TI DOSE-RESPONSE PROFILES FOR PROGESTERONE, DEXTROMETHORPHAN, AND SIMVASTATIN IN A MODEL OF PENETRATING BALLISTIC-LIKE BRAIN INJURY SO JOURNAL OF NEUROTRAUMA LA English DT Meeting Abstract CT 30th Annual National Neurotrauma Symposium CY JUL 22-25, 2012 CL Phoenix, AZ DE PBBI; dextromethorphan; progesterone; simvastatin; dose-response C1 [Shear, Deborah A.; Mountney, Andrea; Pedersen, Rebecca; Sun, Justin; Long, Melissa; Lu, Xi-Chun M.; Tortella, Frank C.] Walter Reed Army Inst Res, Silver Spring, MD USA. RI Shear, Deborah/B-3607-2011 NR 0 TC 0 Z9 0 U1 0 U2 3 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 J9 J NEUROTRAUM JI J. Neurotrauma PD JUL PY 2012 VL 29 IS 10 BP A123 EP A123 PG 1 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA 971YV UT WOS:000306244400209 ER PT J AU Shear, DA Pedersen, R Sun, J Long, M Schmid, K Tortella, FC AF Shear, Deborah A. Pedersen, Rebecca Sun, Justin Long, Melissa Schmid, Kara Tortella, Frank C. TI OPERATION BRAIN TRAUMA THERAPY CONSORTIUM: DOSE-RESPONSE EVALUATION OF NICOTINAMIDE IN THE WRAIR MODEL OF PENETRATING BALLISTIC-LIKE BRAIN INJURY SO JOURNAL OF NEUROTRAUMA LA English DT Meeting Abstract CT 30th Annual National Neurotrauma Symposium CY JUL 22-25, 2012 CL Phoenix, AZ DE PBBI; TBI; nicotinamide; OBTT; WRAIR C1 [Shear, Deborah A.; Pedersen, Rebecca; Sun, Justin; Long, Melissa; Schmid, Kara; Tortella, Frank C.] Walter Reed Army Inst Res, Silver Spring, MD USA. RI Shear, Deborah/B-3607-2011 NR 0 TC 0 Z9 0 U1 0 U2 1 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 J9 J NEUROTRAUM JI J. Neurotrauma PD JUL PY 2012 VL 29 IS 10 BP A72 EP A73 PG 2 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA 971YV UT WOS:000306244400120 ER PT J AU Simon, JC Jackson, C Yokobori, S Gajavelli, S Bidot, CJ Jy, W Spurlock, M Leung, LY Tortella, F Bullock, R AF Simon, Julio C. Jackson, Clayton Yokobori, Shoji Gajavelli, Shyam Bidot, Carlos J. Jy, Wenche Spurlock, Markus Leung, Lai Yee Tortella, Frank Bullock, Ross TI PENETRATING BALLISTIC-LIKE BRAIN INJURY (PBBI) INDUCES COAGULOPATHY WITH REDUCTION OF PLATELET-FIBRIN INTERACTION: A STUDY OF THROMBOELASTOGRAPHY IN A RAT MODEL SO JOURNAL OF NEUROTRAUMA LA English DT Meeting Abstract CT 30th Annual National Neurotrauma Symposium CY JUL 22-25, 2012 CL Phoenix, AZ DE Blood; Thromboelastography; TEG; PBBI; TBI C1 [Jackson, Clayton; Yokobori, Shoji; Gajavelli, Shyam; Spurlock, Markus; Bullock, Ross] Univ Miami, Miller Sch Med, Dept Neurosurg, Miami Project Cure Paralysis, Coral Gables, FL 33124 USA. [Leung, Lai Yee] Walter Reed Army Inst Res, Silver Spring, MD USA. [Tortella, Frank] WRAIR, Ctr Excellence Psychiat & Neurosci, Brain Trauma Neuroprotect & Neurorestorat Branch, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 J9 J NEUROTRAUM JI J. Neurotrauma PD JUL PY 2012 VL 29 IS 10 BP A55 EP A55 PG 1 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA 971YV UT WOS:000306244400091 ER PT J AU Valiyaveettil, M Alamneh, Y Wang, Y Arun, P Oguntaya, S Wei, YL Long, J Nambiar, M AF Valiyaveettil, Manojkumar Alamneh, Yonas Wang, Ying Arun, Peethambaran Oguntaya, Samuel Wei, Yanling Long, Joseph Nambiar, Madhusoodana TI FUNCTIONAL SIGNIFICANCE OF SYSTEMIC FACTORS IN THE PATHOPHYSIOLOGY OF BLAST-INDUCED NEUROTRAUMA SO JOURNAL OF NEUROTRAUMA LA English DT Meeting Abstract CT 30th Annual National Neurotrauma Symposium CY JUL 22-25, 2012 CL Phoenix, AZ DE TBI; blast exposure; platelets; leukocytes C1 [Valiyaveettil, Manojkumar; Alamneh, Yonas; Wang, Ying; Arun, Peethambaran; Oguntaya, Samuel; Wei, Yanling; Long, Joseph; Nambiar, Madhusoodana] Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 J9 J NEUROTRAUM JI J. Neurotrauma PD JUL PY 2012 VL 29 IS 10 BP A173 EP A173 PG 1 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA 971YV UT WOS:000306244400298 ER PT J AU Wang, Y Wei, YL Oguntaya, S Gist, I Long, J Nambiar, M AF Wang, Ying Wei, Yanling Oguntaya, Samuel Gist, Irene Long, Joseph Nambiar, Madhusoodana TI INCREASE IN CELL-FREE DNA LEVEL AND BRAIN DNA DAMAGE AFTER BLAST EXPOSURES SO JOURNAL OF NEUROTRAUMA LA English DT Meeting Abstract CT 30th Annual National Neurotrauma Symposium CY JUL 22-25, 2012 CL Phoenix, AZ DE Blast; Neurotrauma; DNA damage; Cell-free-DNA C1 [Wang, Ying; Wei, Yanling; Oguntaya, Samuel; Gist, Irene; Long, Joseph; Nambiar, Madhusoodana] Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 1 U2 2 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 J9 J NEUROTRAUM JI J. Neurotrauma PD JUL PY 2012 VL 29 IS 10 BP A219 EP A219 PG 1 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA 971YV UT WOS:000306244400382 ER PT J AU Wei, G Yang, XF Leung, LY Mountney, A Shear, DA Tortella, FC AF Wei, Guo Yang, Xiaofang Leung, Lai Yee Mountney, Andrea Shear, Deborah A. Tortella, Frank C. TI EFFECT OF SELECTIVE BRAIN COOLING ON THE FUNCTIONAL RECOVERY FOLLOWING PENETRATING BALLISTIC-LIKE BRAIN INJURY IN RATS SO JOURNAL OF NEUROTRAUMA LA English DT Meeting Abstract CT 30th Annual National Neurotrauma Symposium CY JUL 22-25, 2012 CL Phoenix, AZ DE PBBI, Hypothermia; Functional recovery C1 [Wei, Guo; Yang, Xiaofang; Leung, Lai Yee; Mountney, Andrea; Shear, Deborah A.; Tortella, Frank C.] Walter Reed Army Inst Res, Silver Spring, MD USA. RI Shear, Deborah/B-3607-2011 NR 0 TC 0 Z9 0 U1 0 U2 2 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 J9 J NEUROTRAUM JI J. Neurotrauma PD JUL PY 2012 VL 29 IS 10 BP A174 EP A175 PG 2 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA 971YV UT WOS:000306244400301 ER PT J AU Sablon, KA Little, JW Sergeev, A Vagidov, N Mitin, V AF Sablon, Kimberly A. Little, John W. Sergeev, Andrei Vagidov, Nizami Mitin, Vladimir TI Solar cell with built-in charge: Experimental studies of diode model parameters SO JOURNAL OF VACUUM SCIENCE & TECHNOLOGY A LA English DT Article ID QUANTUM DOTS; EFFICIENCY AB Quantum dots acquire built-in charge due to selective n-doping of the interdot space. The quantum dots with built-in charge (Q-BIC) increase electron coupling to IR radiation and suppress photoelectron capture, which in turn decrease the recombination via quantum dots. To investigate effects of the built-in-dot charge on recombination processes and device performance, the light and dark I-V characteristics and their temperature dependences of Q-BIC solar cells are measured. Employing the diode model, the data are analyzed in terms of the ideality factor, shunt resistance, and reverse saturation current. The authors compare the n-doped Q-BIC solar cells with the GaAs p-i-n reference cell, undoped, and p-doped devices. The analysis provides a qualitative description of the effect of doping on carrier kinetics and transport. The authors show that n-doping substantially reduces the recombination via quantum dots. (C) 2012 American Vacuum Society. [http://dx.doi.org/10.1116/1.3703607] C1 [Sablon, Kimberly A.; Little, John W.] USA, Res Lab, Adelphi, MD 20783 USA. [Sergeev, Andrei; Vagidov, Nizami; Mitin, Vladimir] SUNY Buffalo, Buffalo, NY 14260 USA. RP Sablon, KA (reprint author), USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM kimberly.a.sablonramsey.civ@mail.mil FU Air Force Office of Scientific Research (AFOSR) FX This work was supported by the Air Force Office of Scientific Research (AFOSR). The authors thank Kimberley Olver for sample processing and Fred Towner of Maxion Technologies, Inc. for MBE growth. NR 15 TC 8 Z9 8 U1 0 U2 9 PU A V S AMER INST PHYSICS PI MELVILLE PA STE 1 NO 1, 2 HUNTINGTON QUADRANGLE, MELVILLE, NY 11747-4502 USA SN 0734-2101 J9 J VAC SCI TECHNOL A JI J. Vac. Sci. Technol. A PD JUL PY 2012 VL 30 IS 4 AR 04D104 DI 10.1116/1.3703607 PG 4 WC Materials Science, Coatings & Films; Physics, Applied SC Materials Science; Physics GA 970OW UT WOS:000306142800013 ER PT J AU Abadie, J AF Abadie, Jude TI How Can the Clinical Picture Guide Appropriate Laboratory Drug Testing in the Treatment of Pain Clinic Patients with Opioid Analgesics? SO PAIN MEDICINE LA English DT Editorial Material C1 Tripler Army Med Ctr, Core Lab, Out Patient Lab, Honolulu, HI 96859 USA. RP Abadie, J (reprint author), Tripler Army Med Ctr, Core Lab, Out Patient Lab, Honolulu, HI 96859 USA. NR 7 TC 2 Z9 2 U1 0 U2 1 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1526-2375 J9 PAIN MED JI Pain Med. PD JUL PY 2012 VL 13 IS 7 BP 857 EP 859 DI 10.1111/j.1526-4637.2012.01421.x PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA 973LA UT WOS:000306360400002 PM 22804904 ER PT J AU Buckenmaier, C Mahoney, PF Anton, T Kwon, N Polomano, RC AF Buckenmaier, Chester Trip, III Mahoney, Peter F. Anton, Todd Kwon, Nancy Polomano, Rosemary C. TI Impact of an Acute Pain Service on Pain Outcomes with Combat-Injured Soldiers at Camp Bastion, Afghanistan SO PAIN MEDICINE LA English DT Article DE Acute Pain Service; Military Medicine; Traumatology; Wounds and Injuries; Regional Anesthesia ID FEMORAL BONE-FRACTURES; BATTLEFIELD ANESTHESIA; GLOBAL WAR; MANAGEMENT; BLOCK; CARE; EVACUATION; OPERATIONS; TERRORISM; PATIENT AB Background. Few studies demonstrate the impact of early aggressive analgesia with acute pain service (APS) involvement at combat support hospitals (CSHs) using real-time data. Collaboration between the British and the United States (US) Army led to a 3-month deployment of a US Army APS to Camp Bastion, the main British military base in southern Afghanistan, from April to July 2009. Methods. Pain outcomes data were collected at Camp Bastion from 71 soldiers sustaining major combat injuries followed by an APS. Results. The sample was predominantly male (98.6%) and Caucasian (98.8%) with a mean age 25.4 years +/- 5.4 (range 1845). Regional nerve blocks were performed in 51 (71.8%) and epidurals placed in 11 (15.5%) of the cases. Repeated measures analysis of variance showed a statistically significant decreases in pain intensity (numeric rating scale from 0 for none to 10 for as bad as you can imagine) over the three data collection points; first 3, 46, and 710 hours (F = 133.35; degrees of freedom [df; 1,68]; P < 0.001). Mean percent pain relief (0% no relief to 100% complete relief) increased significantly over time (F = 193.12; df[1,69]; P < 0.001) with scores 31.29% +/- 20.3 (initial 3 hours), 74.86% +/- 27.5 (46 hours), and 83.14% +/- 19.3 (724 hours). Overall, the perceived quality of pain control by soldiers was high. Conclusions. Findings from this quality of pain care study show that aggressive multimodal analgesia interventions by an APS in a CSH is associated with decreased pain intensity and increased pain relief. C1 [Buckenmaier, Chester Trip, III; Kwon, Nancy] Def & Vet Ctr Integrat Pain Management, Rockville, MD 20852 USA. [Buckenmaier, Chester Trip, III] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [Buckenmaier, Chester Trip, III; Anton, Todd] Walter Reed Army Med Ctr, Dept Surg, Washington, DC 20307 USA. [Polomano, Rosemary C.] Univ Penn, Sch Nursing, Philadelphia, PA 19104 USA. [Polomano, Rosemary C.] Univ Penn, Sch Med, Philadelphia, PA 19104 USA. [Mahoney, Peter F.] Royal Ctr Def Med, Birmingham, W Midlands, England. RP Def & Vet Ctr Integrat Pain Management, 11300 Rockville Pike,Suite 709, Rockville, MD 20852 USA. EM cbuckenmaier@dvpmi.org OI Buckenmaier III, Chester/0000-0003-3623-5525 FU Defense and Veterans Center for Integrative Pain Management FX This work was supported by institutional funding and the Defense and Veterans Center for Integrative Pain Management. All authors have no conflicts of interest to disclose. NR 22 TC 5 Z9 5 U1 1 U2 6 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1526-2375 J9 PAIN MED JI Pain Med. PD JUL PY 2012 VL 13 IS 7 BP 919 EP 926 DI 10.1111/j.1526-4637.2012.01382.x PG 8 WC Medicine, General & Internal SC General & Internal Medicine GA 973LA UT WOS:000306360400010 PM 22694122 ER PT J AU Polomano, RC Chisholm, E Anton, TM Kwon, N Mahoney, PF Buckenmaier, C AF Polomano, Rosemary C. Chisholm, Ellie Anton, Todd M. Kwon, Nancy Mahoney, Peter F. Buckenmaier, Chester Trip, III TI A Survey of Military Health Professionals' Perceptions of an Acute Pain Service at Camp Bastion, Afghanistan SO PAIN MEDICINE LA English DT Article DE Acute Pain Service; Regional Anesthesia; Military Medicine ID REGIONAL ANESTHESIA OUTCOMES; POSTOPERATIVE PAIN; SURGEONS ATTITUDES; GLOBAL WAR; MANAGEMENT; OPERATIONS; DECISIONS; TERRORISM; KNOWLEDGE; UK AB Objective. The primary goal of this investigation was to survey military health care professionals at a Camp Bastion, Afghanistan, regarding their perceptions of care delivered by an anesthesiologist-directed acute pain service (APS) at a British Combat Support Hospital (CSH)Role 3. Methods. The APS was directed by a U.S. Army anesthesiologist experienced in acute pain medicine who established an APS within a deployed British CSH. A brief 15-item survey was developed to assess impressions of outcomes, complexity of care, and satisfaction with the APS. Content validity was established through limited published surveys of APSs, expert review, and end user evaluation. Results. The sample (N = 70, of which 61.4% were male) included 50% nurses, 15.8% surgeons, and 10% anesthesiologists who completed the survey at the end of the 3-month APS implementation period. Approximately 75% of the sample agreed or strongly agreed that injured soldiers managed by an APS obtained better pain relief than those who were not. With a 10-point scale, respondents rated how satisfied they were with the APS (mean 7.70 +/- 1.7), how beneficial it was for patients (7.89 +/- 2), and how important it would be to deploy an APS again to a level 3 facility (8.52 +/- 1.7). Internal consistency reliability (Cronbach's alpha) for the 12-items measuring perceptions was acceptable, alpha = 0.82. Conclusions. Overall, the majority of military health care survey responders indicated support for an APS team as part of a CSH care, and confirmed its contributions to improving trauma care. C1 [Kwon, Nancy; Buckenmaier, Chester Trip, III] Walter Reed Army Med Ctr, Def & Vet Ctr Integrat Pain Management, Rockville, MD 20852 USA. [Polomano, Rosemary C.] Univ Penn, Sch Nursing, Philadelphia, PA 19104 USA. [Polomano, Rosemary C.] Univ Penn, Sch Med, Philadelphia, PA 19104 USA. [Anton, Todd M.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [Buckenmaier, Chester Trip, III] USUHS, Bethesda, MD USA. [Chisholm, Ellie] QARANC V, York, N Yorkshire, England. [Mahoney, Peter F.] DMA & CC RCDM, Birmingham, W Midlands, England. RP Buckenmaier, C (reprint author), Walter Reed Army Med Ctr, Def & Vet Ctr Integrat Pain Management, 11300 Rockville Pike,Suite 709, Rockville, MD 20852 USA. EM chester.buckenmaier@us.army.mil OI Buckenmaier III, Chester/0000-0003-3623-5525 FU Defense and Veterans Center for Integrative Pain Management FX This work was supported by institutional funding and the Defense and Veterans Center for Integrative Pain Management. All authors have no conflicts of interest to disclose. NR 29 TC 1 Z9 1 U1 1 U2 6 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1526-2375 EI 1526-4637 J9 PAIN MED JI Pain Med. PD JUL PY 2012 VL 13 IS 7 BP 927 EP 936 DI 10.1111/j.1526-4637.2012.01415.x PG 10 WC Medicine, General & Internal SC General & Internal Medicine GA 973LA UT WOS:000306360400011 PM 22694183 ER PT J AU Moore, CE Blacksell, SD Taojaikong, T Jarman, RG Gibbons, RV Lee, SJ Chansamouth, V Thongpaseuth, S Mayxay, M Newton, PN AF Moore, Catrin E. Blacksell, Stuart D. Taojaikong, Thaksinaporn Jarman, Richard G. Gibbons, Robert V. Lee, Sue J. Chansamouth, Vilada Thongpaseuth, Soulignasack Mayxay, Mayfong Newton, Paul N. TI A Prospective Assessment of the Accuracy of Commercial IgM ELISAs in Diagnosis of Japanese Encephalitis Virus Infections in Patients with Suspected Central Nervous System Infections in Laos SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID LINKED IMMUNOSORBENT ASSAYS; IMMUNOGLOBULIN-M ANTIBODIES; CEREBROSPINAL-FLUID; HEMORRHAGIC-FEVER; CAPTURE ELISA; CHILDREN; VIETNAM; SAMPLES; DENGUE; SERUM AB Japanese encephalitis virus (JEV) is a major cause of encephalitis in Asia. We estimated the diagnostic accuracy of two anti-JEV immunoglobulin M (IgM) enzyme-linked immunosorbent assays (ELISAs) (Panbio and XCyton JEVCheX) compared with a reference standard (AFRIMS JEV MAC ELISA) in a prospective study of the causes of central nervous system infections in Laos. Cerebrospinal fluid (CSF; 515 patients) and serum samples (182 patients) from those admitted to Mahosot Hospital, Vientiane, were tested. The CSF from 14.5% of acute encephalitis syndrome (AES) patients and 10.1% from those with AES and meningitis were positive for anti-JEV IgM in the reference ELISA. The sensitivities for CSF were 65.4% (95% confidence interval [CI] = 51-78) (Xcyton), 69.2% (95% CI = 55-81) (Panbio), however 96.2% (95% CI = 87-100) with Panbio Ravi criteria. Specificities were 89-100%. For admission sera from AES patients, sensitivities and specificities of the Panbio ELISA were 85.7% (95% CI = 42-100%) and 92.9% (95% CI = 83-98%), respectively. C1 [Newton, Paul N.] Mahosot Hosp, Microbiol Lab, Wellcome Trust Mahosot Hosp Oxford Trop Med Res C, Viangchan, Laos. Univ Oxford, Nuffield Dept Clin Med, Ctr Clin Vaccinol & Trop Med, Oxford, England. [Blacksell, Stuart D.; Lee, Sue J.] Mahidol Univ, Fac Trop Med, Bangkok, Thailand. [Jarman, Richard G.; Gibbons, Robert V.] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. RP Newton, PN (reprint author), Mahosot Hosp, Microbiol Lab, Wellcome Trust Mahosot Hosp Oxford Trop Med Res C, Viangchan, Laos. EM catrin@tropmedres.ac; stuart@tropmedres.ac; im@tropmedres.ac; Richard.Jarman@afrims.org; Robert.Gibbons@afrims.org; sue@tropmedres.ac; vilada@tropmedres.ac; sack@tropmedres.ac; mayfong@tropmedres.ac; paul@tropmedres.ac OI Blacksell, Stuart/0000-0001-6576-726X FU WPRO; Wellcome Trust of Great Britain; JE project at PATH; Bill and Melinda Gates Foundation FX This study was funded by WPRO, the JE project at PATH through support from the Bill and Melinda Gates Foundation, and the Wellcome Trust of Great Britain. NR 27 TC 7 Z9 7 U1 0 U2 4 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD JUL PY 2012 VL 87 IS 1 BP 171 EP 178 DI 10.4269/ajtmh.2012.11-0729 PG 8 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 970SV UT WOS:000306153500029 PM 22764310 ER PT J AU Steinhardt, L Arguin, P Magill, A AF Steinhardt, Laura Arguin, Paul Magill, Alan TI Malaria Prophylaxis in Latin America: A Controversial Topic Response SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Letter ID TRAVELERS; PRIMAQUINE; CHEMOPROPHYLAXIS C1 [Steinhardt, Laura; Arguin, Paul] Ctr Dis Control & Prevent, Malaria Branch, Div Parasit Dis & Malaria, Atlanta, GA 30333 USA. [Magill, Alan] Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD USA. RP Steinhardt, L (reprint author), Ctr Dis Control & Prevent, Malaria Branch, Div Parasit Dis & Malaria, Atlanta, GA 30333 USA. EM lsteinhardt@cdc.gov NR 9 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD JUL PY 2012 VL 87 IS 1 BP 192 EP 192 DI 10.4269/ajtmh.2012.12-0193b PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 970SV UT WOS:000306153500033 ER PT J AU Howle, JF Bawden, GW Schweickeret, RA Finkel, RC Hunter, LE Rose, RS von Twistern, B AF Howle, James F. Bawden, Gerald W. Schweickeret, Richard A. Finkel, Robert C. Hunter, Lewis E. Rose, Ronn S. von Twistern, Brent TI Airborne LiDAR analysis and geochronology of faulted glacial moraines in the Tahoe-Sierra frontal fault zone reveal substantial seismic hazards in the Lake Tahoe region, California-Nevada, USA SO GEOLOGICAL SOCIETY OF AMERICA BULLETIN LA English DT Article ID PLEISTOCENE GLACIATION; MONO BASIN; CHRONOLOGY; EARTHQUAKES; RANGE; SIMULATIONS; MAGNITUDE; EXTENSION; RUPTURE; NORTH AB We integrated high-resolution bare-earth airborne light detection and ranging (LiDAR) imagery with field observations and modern geochronology to characterize the Tahoe-Sierra frontal fault zone, which forms the neotectonic boundary between the Sierra Nevada and the Basin and Range Province west of Lake Tahoe. The LiDAR imagery clearly delineates active normal faults that have displaced late Pleistocene glacial moraines and Holocene alluvium along 30 km of linear, right-stepping range front of the Tahoe-Sierra frontal fault zone. Herein, we illustrate and describe the tectonic geomorphology of faulted lateral moraines. We have developed new, three-dimensional modeling techniques that utilize the high-resolution LiDAR data to determine tectonic displacements of moraine crests and alluvium. The statistically robust displacement models combined with new ages of the displaced Tioga (20.8 +/- 1.4 ka) and Tahoe (69.2 +/- 4.8 ka; 73.2 +/- 8.7 ka) moraines are used to estimate the minimum vertical separation rate at 17 sites along the Tahoe-Sierra frontal fault zone. Near the northern end of the study area, the minimum vertical separation rate is 1.5 +/- 0.4 mm/yr, which represents a two-to threefold increase in estimates of seismic moment for the Lake Tahoe basin. From this study, we conclude that potential earthquake moment magnitudes (M-w) range from 6.3 +/- 0.25 to 6.9 +/- 0.25. A close spatial association of landslides and active faults suggests that landslides have been seismically triggered. Our study underscores that the Tahoe-Sierra frontal fault zone poses substantial seismic and landslide hazards. C1 [Howle, James F.] US Geol Survey, Carnelian Bay, CA 96140 USA. [Bawden, Gerald W.] US Geol Survey, Sacramento, CA 95819 USA. [Schweickeret, Richard A.] Univ Nevada, Dept Geol Sci, Reno, NV 89509 USA. [Finkel, Robert C.] Univ Calif Berkeley, Dept Earth & Planetary Sci, Berkeley, CA 94720 USA. [Hunter, Lewis E.; Rose, Ronn S.] USA, Corps Engineers, Sacramento, CA 95814 USA. RP Howle, JF (reprint author), US Geol Survey, POB 1360, Carnelian Bay, CA 96140 USA. EM jfhowle@usgs.gov; gbawden@usgs.gov; rschweickert@gmail.com; rfinkel@berkeley.edu; lewis.e.hunter@usace.army.mil; ronn.s.rose@usace.army.mil; bvtwist@journeyaroundhappy.com FU U.S. Army Corp of Engineers, Dam Safety Assurance Program FX This study was funded, in part, by the U.S. Army Corp of Engineers, Dam Safety Assurance Program. JFH would like to thank Keith Kelson for his input during preparation of an early version of this paper. We are grateful for constructive colleague reviews by James Lienkaemper, Kenneth Hudnut, Andrew Cyr, and peer reviews by Arthur Sylvester and an anonymous reviewer, all of which improved the manuscript. Any use of trade, product, or firm names is for descriptive purposes only and does not imply endorsement by the U.S. government. NR 57 TC 11 Z9 11 U1 3 U2 21 PU GEOLOGICAL SOC AMER, INC PI BOULDER PA PO BOX 9140, BOULDER, CO 80301-9140 USA SN 0016-7606 J9 GEOL SOC AM BULL JI Geol. Soc. Am. Bull. PD JUL-AUG PY 2012 VL 124 IS 7-8 BP 1087 EP 1101 DI 10.1130/B30598.1 PG 15 WC Geosciences, Multidisciplinary SC Geology GA 966YD UT WOS:000305872400004 ER PT J AU Adley, MD Frank, AO Danielson, KT Akers, SA Cargile, JD Patterson, BC Termaath, S AF Adley, Mark D. Frank, Andreas O. Danielson, Kent T. Akers, Stephen A. Cargile, James D. Patterson, Bruce C. Termaath, Stephanie TI GENERATING PENETRATION RESISTANCE FUNCTIONS WITH A VIRTUAL PENETRATION LABORATORY (VPL): APPLICATIONS TO PROJECTILE PENETRATION AND STRUCTURAL RESPONSE SIMULATIONS SO INTERNATIONAL JOURNAL OF STRUCTURAL STABILITY AND DYNAMICS LA English DT Article DE Penetration mechanics; constitutive modeling; cavity expansion ID MICROPLANE MODEL M4; LARGE-DEFORMATION; CONCRETE TARGETS; ALUMINUM TARGETS; MESHLESS METHODS; STRAIN; STRENGTH; STRESS; RODS AB A new software package called the Virtual Penetration Laboratory (VPL) has been developed to automatically generate and optimize penetration resistance functions. We have used this VPL code to generate highly "tuned" penetration resistance functions that can distinctly model the penetration trajectory of steel projectiles into rate-independent, elastic-perfectly plastic aluminum targets. Projectiles with arbitrary nose geometry were considered in this example (i.e. conical, ogival, and spherical nose shapes). The penetration resistance of the aluminum target was determined by numerically solving a series of spherical and cylindrical cavity expansion problems. The solution to these cavity expansion problems were obtained with an explicit, dynamic finite element code that accounts for material and geometric nonlinearities. The resulting cavity expansion equations are then transformed to penetration resistance functions using various transformation algorithms, in order to determine an appropriate method to spatially distribute the resisting stresses on the projectile nose. The resulting penetration resistance functions were then used in a penetration trajectory code to predict the actual trajectories observed from a set of similar experiments. C1 [Adley, Mark D.; Frank, Andreas O.; Danielson, Kent T.; Akers, Stephen A.; Cargile, James D.] USA, Engn Res & Dev Ctr, ATTN CEERD GM I 3909, Vicksburg, MS 39180 USA. [Patterson, Bruce C.] USAF, Res Lab Munit Directorate, Eglin AFB, FL USA. [Termaath, Stephanie] Appl Res Associates Inc, Ft Worth, TX USA. RP Adley, MD (reprint author), USA, Engn Res & Dev Ctr, ATTN CEERD GM I 3909, Halls Ferry Rd Vicksburg, Vicksburg, MS 39180 USA. EM mark.d.adley@erdc.usace.army.mil FU [DAAD19-03-D-0001] FX The research reported herein was conducted as part of the U.S. Army Corps of Engineers Survivability and Protective Structures Technical Area, Hardened Combined Effects Penetrator Warheads Work Package, Work Unit "HPC Prediction of Weapon Penetration, Blast and Secondary Effects". The third author's contributions were performed in connection with contract DAAD19-03-D-0001 with the U.S. Army Research Laboratory. The authors gratefully acknowledge M. Forrestal and T. Warren for sharing their extensive notes on cavity expansion solution techniques and for numerous discussions over the years. Permission to publish was granted by Director, Geotechnical and Structures Laboratory. NR 41 TC 0 Z9 0 U1 2 U2 8 PU WORLD SCIENTIFIC PUBL CO PTE LTD PI SINGAPORE PA 5 TOH TUCK LINK, SINGAPORE 596224, SINGAPORE SN 0219-4554 J9 INT J STRUCT STAB DY JI Int. J. Struct. Stab. Dyn. PD JUL PY 2012 VL 12 IS 4 AR 1250024 DI 10.1142/S0219455412500241 PG 25 WC Engineering, Civil; Engineering, Mechanical; Mechanics SC Engineering; Mechanics GA 973BQ UT WOS:000306327100003 ER PT J AU Havard, MAJRW AF Havard, M. A. J. Ronald W. TI Setting a New Standard: Increasing Capacity at the Fort Drum Environmental Health Department SO JOURNAL OF ENVIRONMENTAL HEALTH LA English DT Editorial Material C1 USA, Environm Hlth Sect, Ft Hood, TX 76544 USA. RP Havard, MAJRW (reprint author), USA, Environm Hlth Sect, 7162 Lorraine Loop, Ft Hood, TX 76544 USA. EM ronald.havard@us.army.mil NR 0 TC 0 Z9 0 U1 0 U2 0 PU NATL ENVIRON HEALTH ASSOC PI DENVER PA 720 S COLORADO BLVD SUITE 970, SOUTH TOWER, DENVER, CO 80246 USA SN 0022-0892 J9 J ENVIRON HEALTH JI J. Environ. Health PD JUL-AUG PY 2012 VL 75 IS 1 BP 26 EP 27 PG 2 WC Environmental Sciences; Public, Environmental & Occupational Health SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health GA 970UX UT WOS:000306158900005 ER PT J AU Reiter, M Wiedenhoefer, JF Schwope, R Feathers, A Page, S AF Reiter, Michael Wiedenhoefer, James F. Schwope, Ryan Feathers, Abigail Page, Sarah TI Use of MRI for Evaluation of Retained Uterine Fundus Mimicking a Pelvic Mass SO JOURNAL OF MINIMALLY INVASIVE GYNECOLOGY LA English DT Article DE Retained uterine fundus; Vaginal hysterectomy; MRI ID VAGINAL HYSTERECTOMY AB Increased use of less invasive hysterectomy techniques requires awareness of the unique potential complications they pose in patients with continued symptoms after surgery. Retained uterine fundus is rare after vaginal hysterectomy; only 2 other cases have been reported in the English literature. Magnetic resonance imaging (MRI) was not used preoperatively in either case. However, imaging evaluation, in particular with MRI because of its superior soft tissue resolution, can be helpful in suggesting the diagnosis. Herein is presented the case of a 40-year-old woman who had undergone vaginal hysterectomy several years previously, but was experiencing abdominal pain. MRI was performed, which revealed a supravesical mass. Visualization at MRI of intact round ligaments arising from the mass favored the diagnosis of retained uterine fundus and confirmed after surgical excision. Journal of Minimally Invasive Gynecology (2012) 19, 524-526 Published by Elsevier Inc. on behalf of AAGL. C1 [Reiter, Michael; Wiedenhoefer, James F.; Schwope, Ryan] Brooke Army Med Ctr, Dept Radiol, San Antonio, TX 78234 USA. [Feathers, Abigail; Page, Sarah] Brooke Army Med Ctr, Dept Obstet & Gynecol, San Antonio, TX 78234 USA. RP Reiter, M (reprint author), Brooke Army Med Ctr, Dept Radiol, 3851 Roger Brooke Dr, San Antonio, TX 78234 USA. EM michael.reiter1@us.army.mil NR 6 TC 0 Z9 0 U1 0 U2 1 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1553-4650 J9 J MINIM INVAS GYN JI J. Mimim. Invasive Gynecol. PD JUL-AUG PY 2012 VL 19 IS 4 BP 524 EP 526 DI 10.1016/j.jmig.2012.03.018 PG 3 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA 971KI UT WOS:000306202400023 PM 22748959 ER PT J AU Croy, T Saliba, S Saliba, E Anderson, MW Hertel, J AF Croy, Theodore Saliba, Susan Saliba, Ethan Anderson, Mark W. Hertel, Jay TI Differences in Lateral Ankle Laxity Measured via Stress Ultrasonography in Individuals With Chronic Ankle Instability, Ankle Sprain Copers, and Healthy Individuals SO JOURNAL OF ORTHOPAEDIC & SPORTS PHYSICAL THERAPY LA English DT Article DE anterior drawer test; anterior talofibular ligament; inversion; sprain ID STRAIN-MEASUREMENT; LIGAMENT INJURIES; ABILITY MEASURE; ANATOMY; ULTRASOUND; DIAGNOSIS; FOOT; RADIOGRAPHY; RELIABILITY; VALIDITY AB STUDY DESIGN: Cross-sectional. OBJECTIVE: To use stress ultrasonography to measure the change in anterior talofibular ligament length during the simulated anterior drawer and ankle inversion stress tests. BACKGROUND: In approximately 30% of individuals, ankle sprains may eventually develop into chronic ankle instability (CAI) with recurrent symptoms. Individuals with CAI and those who have a history of ankle sprain (greater than 1 year prior) without chronic instability (copers) may or may not have mechanical laxity. METHODS: Sixty subjects (n = 60 ankles) were divided into 3 groups: (1) control subjects without ankle injury history (n = 20; mean +/- SD age, 24.8 +/- 4.8 years; height, 173.7 +/- 9.4 cm; mass, 77.2 +/- 19.5 kg), ankle sprain copers (n = 20; mean +/- SD age, 22.3 +/- 2.9 years; height, 172.8 +/- 11.3 cm; mass, 72.4 +/- 14.3 kg), and subjects with CAI (n = 20; mean +/- SD age, 23.5 +/- 4.2 years; height, 174.6 +/- 9.6 cm; mass, 74.8 +/- 17.3 kg). Ligament length change with the anterior drawer test and end range ankle inversion were calculated from ultrasound images. The Foot and Ankle Ability Measure was used to quantify self-reported function on activities of daily living and sports. RESULTS: The anterior drawer test resulted in length changes that were greater (F-2.57 = 6.2, P = .004) in the CAI (mean +/- SD length change, 15.6% +/- 15.1%; P = .006) and the coper groups (14.0% +/- 15.9%, P = .016) compared to the control group (1.3% +/- 10.7%); however, the length changes for the CAI and coper groups were not different (P = .93). Ankle inversion similarly resulted in greater ligament-length change (F-2.57 = 6.5, P = .003) in the CAI (25.3% +/- 15.5%, P = .003) and coper groups (20.2% +/- 19.6%, P = .039) compared to the control group (7.4% +/- 12.9%), with no difference in length change between the coper and CAI groups (P = .59). The CAI group had a lower score on the Foot and Ankle Ability Measure activities of daily living subscale (87.4% +/- 13.4%) and sports subscale (74.2% +/- 17.8%) compared to the control group (98.8% +/- 2.9% and 98.9% +/- 3.1%, respectively; P <.0001) and caper group (99.4% +/- 1.8% and 94.6% +/- 8.8%, respectively; P <.0001). CONCLUSION: Stress ultrasonography identified greater length changes of the anterior talofibular ligament ligament in both the coper and CAI groups compared to the control group. Only subjects with CAI had reductions in self-reported function. J Orthop Sports Phys Ther 2012;42(7):593-600, Epub 23 March 2012. doi:10.2519/jospt.2012.3923 C1 [Croy, Theodore] USA, Baylor Univ Doctoral Program Phys Therapy, Ft Sam Houston, TX 78234 USA. [Hertel, Jay] Univ Virginia, Kinesiol Program, Charlottesville, VA USA. [Croy, Theodore] USA, Med Specialist Corps, Ft Sam Houston, TX 78234 USA. RP Croy, T (reprint author), USA, Baylor Univ Doctoral Program Phys Therapy, Ft Sam Houston, TX 78234 USA. EM tcroypt@gmail.com OI Croy, Theodore/0000-0002-3053-8974; Saliba, Susan/0000-0001-7179-8310 FU Retired Army Medical Specialist Corps Association (RAMSCA) FX The authors would like to thank Nicole Cosby, PhD, ATC for her assistance with this project. Grant funding was provided by the Retired Army Medical Specialist Corps Association (RAMSCA). NR 37 TC 17 Z9 17 U1 0 U2 9 PU J O S P T, PI ALEXANDRIA PA 1111 NORTH FAIRFAX ST, STE 100, ALEXANDRIA, VA 22314-1436 USA SN 0190-6011 J9 J ORTHOP SPORT PHYS JI J. Orthop. Sports Phys. Ther. PD JUL PY 2012 VL 42 IS 7 BP 593 EP 600 DI 10.2519/jospt.2012.3923 PG 8 WC Orthopedics; Rehabilitation; Sport Sciences SC Orthopedics; Rehabilitation; Sport Sciences GA 969YG UT WOS:000306094700002 PM 22446334 ER PT J AU Solomon, NP Helou, LB Makashay, MJ Stojadinovic, A AF Solomon, Nancy Pearl Helou, Leah B. Makashay, Matthew J. Stojadinovic, Alexander TI Aerodynamic Evaluation of the Postthyroidectomy Voice SO JOURNAL OF VOICE LA English DT Article DE Laryngeal airway resistance; Phonation threshold pressure; Airflow; Maximum phonation duration; Fundamental frequency range ID PHONATION THRESHOLD PRESSURE; LARYNGEAL NERVE INJURIES; VOCALLY FATIGUING TASK; SYSTEMIC HYDRATION; SWALLOWING CHANGES; FOLD IMMOBILITY; THYROID-SURGERY; CORD PARALYSIS; SEVERITY INDEX; WARM-UP AB Objectives/Hypotheses. Changes in vocal function before and after thyroidectomy were examined using aerodynamic and related assessments. Laryngeal airway resistance (R-law) and phonation threshold pressure (PTP) were hypothesized to be sensitive to changes in laryngeal function that may occur after thyroidectomy separate from changes that may occur from endotracheal intubation alone. Study Design. Prospective longitudinal clinical trial with comparison group. Methods. Eighty patients were evaluated preoperatively, and 2 weeks and 3 months postoperatively to assess voice outcomes after thyroidectomy. In addition, 16 patients who underwent a nonneck operation were tested as a control group. Maximum phonation time (MPT), mean airflow, R-law, and PTP were determined at two vocal fundamental frequency (F0) levels (30% and 80% of the F0 range). Results. No systematic differences were detected for MPT, mean airflow, or R-law as a short-term or intermediate-term outcome of either surgical group. PTP decreased significantly over time for both groups of participants and at both F0 levels. F0 range decreased significantly at the short-term postsurgical assessment and covaried with the PTP results, thereby explaining some of the variability in the PTP data. Conclusions. Aerodynamic assessment did not reveal systematic changes in vocal function associated with thyroidectomy, although PTP decreased postoperatively for both surgical groups. This may be attributable in part to a learning effect or to postoperative reductions in F0 range. C1 [Solomon, Nancy Pearl; Helou, Leah B.; Makashay, Matthew J.; Stojadinovic, Alexander] Walter Reed Army Med Ctr, Dept Surg, Army Audiol & Speech Ctr, Washington, DC 20307 USA. [Helou, Leah B.] Univ Pittsburgh, Dept Commun Sci & Disorders, Pittsburgh, PA USA. RP Solomon, NP (reprint author), Walter Reed Army Med Ctr, Dept Surg, Army Audiol & Speech Ctr, 6900 Georgia Ave NW, Washington, DC 20307 USA. EM nancy.p.solomon@us.army.mil FU Department of the Army Congressional Program Grant, Army Regional Anesthesia and Pain Management Initiative FX The views expressed in this article are those of the authors and do not reflect the official policy of the Department of Army, Department of Defense, or US Government. We appreciate contributions to this research by Erin Glass, Joyce Gurevich-Uvena, and Leonard Henry. The Department of the Army Congressional Program Grant, Army Regional Anesthesia and Pain Management Initiative, provided partial support for this research. A preliminary version of this study was presented at the 38th Annual Symposium of The Voice Foundation in June 2009 in Philadelphia, PA. NR 53 TC 6 Z9 7 U1 0 U2 2 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0892-1997 J9 J VOICE JI J. Voice PD JUL PY 2012 VL 26 IS 4 BP 454 EP 461 DI 10.1016/j.jvoice.2011.03.010 PG 8 WC Otorhinolaryngology SC Otorhinolaryngology GA 968FA UT WOS:000305961500014 PM 21782386 ER PT J AU Burgess, EB AF Burgess, Edwin B. TI Private: Bradley Manning, WikiLeaks, and the Biggest Exposure of Official Secrets in American History SO LIBRARY JOURNAL LA English DT Book Review C1 [Burgess, Edwin B.] USA, Combined Arms Res Lib, Ft Leavenworth, KS USA. RP Burgess, EB (reprint author), USA, Combined Arms Res Lib, Ft Leavenworth, KS USA. NR 1 TC 0 Z9 0 U1 0 U2 9 PU REED BUSINESS INFORMATION PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010 USA SN 0363-0277 J9 LIBR J JI Libr. J. PD JUL PY 2012 VL 137 IS 12 BP 94 EP 94 PG 1 WC Information Science & Library Science SC Information Science & Library Science GA 972TG UT WOS:000306302500165 ER PT J AU Meitzler, TJ Reynolds, T Ebenstein, S AF Meitzler, Thomas J. Reynolds, Thomas Ebenstein, Samuel TI ARMOR TEST A Technique and Device for Health Monitoring of Glass Armor SO MATERIALS EVALUATION LA English DT Article C1 [Meitzler, Thomas J.; Reynolds, Thomas; Ebenstein, Samuel] USA, RDECOM TARDEC, RDTA RS, Warren, MI 48397 USA. RP Meitzler, TJ (reprint author), USA, RDECOM TARDEC, RDTA RS, MS 263,6501 E 11 Mile Rd, Warren, MI 48397 USA. EM thomas.j.meitzler.civ@mail.mil RI Meitzler, Thomas/D-1065-2017 NR 3 TC 0 Z9 0 U1 0 U2 2 PU AMER SOC NONDESTRUCTIVE TEST PI COLUMBUS PA 1711 ARLINGATE LANE PO BOX 28518, COLUMBUS, OH 43228-0518 USA SN 0025-5327 J9 MATER EVAL JI Mater. Eval. PD JUL PY 2012 VL 70 IS 7 BP 814 EP 820 PG 7 WC Materials Science, Characterization & Testing SC Materials Science GA 972HT UT WOS:000306268600003 ER PT J AU Peiniger, S Nienaber, U Lefering, R Braun, M Wafaisade, A Borgman, MA Spinella, PC Maegele, M AF Peiniger, Sigune Nienaber, Ulrike Lefering, Rolf Braun, Maximilian Wafaisade, Arasch Borgman, Matthew A. Spinella, Philip C. Maegele, Marc CA Trauma Registry Deutsch Gesell Unf TI Glasgow Coma Scale as a predictor for hemocoagulative disorders after blunt pediatric traumatic brain injury SO PEDIATRIC CRITICAL CARE MEDICINE LA English DT Article DE children; Glasgow Coma Scale; hemocoagulative disorders; traumatic brain injury ID SEVERE HEAD-INJURY; SERIAL LABORATORY EXAMINATION; MASSIVE TRANSFUSION; RETROSPECTIVE ANALYSIS; SUBSEQUENT DEVELOPMENT; INDUCED COAGULOPATHY; PROGNOSTIC FACTORS; MULTIPLE INJURY; CHILDREN; COAGULATION AB Objective: Coagulopathy is a complication of traumatic brain injury and its presence after injury has been identified as a risk factor for prognosis. It was our aim to determine whether neurologic findings reflected by Glasgow Coma Scale at initial resuscitation can predict hemocoagulative disorders resulting from traumatic brain injury that may aggravate clinical sequelae and outcome in children. Design: A retrospective analysis of 200 datasets from children with blunt, isolated traumatic brain injury documented in the Trauma Registry of the Deutsche Gesellschaft fur Unfallchirurgie was conducted. Inclusion criteria were primary admission, age <14 yrs, and sustained isolated blunt traumatic brain injury. Setting: Trauma Registry of the Deutsche Gesellschaft fur Unfallchirurgie-affiliated trauma centers in Germany. Patients: Two hundred datasets of children (age <14 yrs) with blunt isolated traumatic brain injury were analyzed: children were subdivided into two groups according to Glasgow Coma Scale at the scene (Glasgow Coma Scale <= 8 vs. Glasgow Coma Scale >8) and reviewed for coagulation abnormalities upon emergency room admission and outcome. Measurement and Main Results: Fifty-one percent (n = 102 of 200) of children had Glasgow Coma Scale >8 and 49% (n = 98 of 200) had Glasgow Coma Scale <= 8 at the scene. The incidence of coagulopathy at admission was higher in children with Glasgow Coma Scale <= 8 compared to children with Glasgow Coma Scale >8: 44% (n = 31 of 71) vs. 14% (n = 11 of 79) (p < .001). Multivariate logistic regression revealed that Glasgow Coma Scale <= 8 at scene was associated with coagulopathy at admission (odds ratio 3.378, p = .009) and stepwise regression identified Glasgow Coma Scale <= 8 as an independent risk factor for coagulopathy. Mortality in children with Glasgow Coma Scale <= 8 at scene was substantially higher with the presence of coagulation abnormalities at admission compared to children in which coagulopathy was absent (51.6%, n = 16 of 31 vs. 5% n = 2 of 40). Conclusions: Glasgow Coma Scale <= 8 at scene in children with isolated traumatic brain injury is associated with increased risk for coagulopathy and mortality. These results may guide laboratory testing, management, and blood bank resources in acute pediatric trauma care. (Pediatr Crit Care Med 2012; 13:455-460) C1 [Peiniger, Sigune; Braun, Maximilian; Wafaisade, Arasch; Maegele, Marc] Univ Witten Herdecke, Cologne Merheim Med Ctr, Dept Trauma & Orthoped Surg, Cologne, Germany. [Peiniger, Sigune; Nienaber, Ulrike; Braun, Maximilian; Wafaisade, Arasch; Maegele, Marc] Univ Witten Herdecke, Cologne Merheim Med Ctr, Inst Res Operat Med, Cologne, Germany. [Borgman, Matthew A.] Brooke Army Med Ctr, Houston, TX USA. [Spinella, Philip C.] Washington Univ, Dept Pediat, St Louis, MO 63130 USA. [Spinella, Philip C.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Maegele, M (reprint author), Univ Witten Herdecke, Cologne Merheim Med Ctr, Dept Trauma & Orthoped Surg, Cologne, Germany. EM Marc.Maegele@t.online.de RI Borgman, Matthew/L-9477-2015 OI Borgman, Matthew/0000-0002-2008-7380 NR 45 TC 9 Z9 13 U1 0 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1529-7535 EI 1947-3893 J9 PEDIATR CRIT CARE ME JI Pediatr. Crit. Care Med. PD JUL PY 2012 VL 13 IS 4 BP 455 EP 460 DI 10.1097/PCC.0b013e31823893c5 PG 6 WC Critical Care Medicine; Pediatrics SC General & Internal Medicine; Pediatrics GA 970FU UT WOS:000306114300023 PM 22422166 ER PT J AU Loh, LC Peik, SM AF Loh, Lawrence C. Peik, Samuel M. TI Public Health Physician Specialty Training in Canada and the United States SO ACADEMIC MEDICINE LA English DT Article ID PREVENTIVE-MEDICINE AB Today's interconnected world has produced a distinct need for physician specialists in public health and preventive medicine. As the industrialized world confronts aging populations, rising health care costs, and a growing epidemic of chronic disease, it is clear that the focus of health care must become more preventive than curative. Although public health and preventive medicine exists in various forms worldwide, the literature has not yet examined different national strategies for postgraduate medical training in this unique specialty. This examination of present-day public health physician training in Canada and the United States represents a first step in addressing this gap. Using a standardized template for review, the authors compare key aspects of public health physician specialty training in both countries, including the definition and scope of the specialty; oversight and location of training; length of postgraduate training; specific clinical, academic, and practicum requirements; residency program funding; availability of residency positions; certification; and the roles of specialists. The authors explore similarities and differences between public health physician specialists in Canada and the United States in an effort to highlight training improvements for incorporation into each country's training program and to identify potential avenues of collaboration and cooperation across the border. C1 [Loh, Lawrence C.] Univ Toronto, Dalla Lana Sch Publ Hlth, Toronto, ON M5T 3M7, Canada. [Peik, Samuel M.] Walter Reed Army Inst Res, Div Prevent Med, Silver Spring, MD USA. RP Loh, LC (reprint author), Univ Toronto, Dalla Lana Sch Publ Hlth, 155 Coll St,6th Floor, Toronto, ON M5T 3M7, Canada. EM lloh@jhsph.edu RI Peik, Samuel/B-7867-2011 NR 46 TC 3 Z9 3 U1 0 U2 4 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1040-2446 J9 ACAD MED JI Acad. Med. PD JUL PY 2012 VL 87 IS 7 BP 904 EP 911 DI 10.1097/ACM.0b013e31825803f3 PG 8 WC Education, Scientific Disciplines; Health Care Sciences & Services SC Education & Educational Research; Health Care Sciences & Services GA 967HL UT WOS:000305897400019 PM 22622209 ER PT J AU Klemanski, DH Mennin, DS Borelli, JL Morrissey, PM Aikins, DE AF Klemanski, David H. Mennin, Douglas S. Borelli, Jessica L. Morrissey, Paul M. Aikins, Deane E. TI EMOTION-RELATED REGULATORY DIFFICULTIES CONTRIBUTE TO NEGATIVE PSYCHOLOGICAL OUTCOMES IN ACTIVE-DUTY IRAQ WAR SOLDIERS WITH AND WITHOUT POSTTRAUMATIC STRESS DISORDER SO DEPRESSION AND ANXIETY LA English DT Article DE posttraumatic stress disorder; PTSD; Iraq; emotion regulation ID MENTAL-HEALTH PROBLEMS; GENERALIZED ANXIETY DISORDER; ALCOHOLISM SCREENING-TEST; VIETNAM COMBAT VETERANS; CHILDHOOD ABUSE; PTSD; AFGHANISTAN; SURVIVORS; EXPOSURE; DYSREGULATION AB Data suggest military personnel involved in U.S. military initiatives in Iraq and Afghanistan are returning from deployment with elevated rates of mental health diagnoses, including posttraumatic stress disorder (PTSD). The aim of this study was to examine difficulties with emotion regulation as a potential contributory mechanism by which soldiers have poorer psychological outcomes, such as depression, dissociation, alcohol abuse, and interpersonal difficulties. Participants were 44 active-duty male service members who comprised three groups, including those deployed with and without diagnosed PTSD and those prior to deployment. Participants in the PTSD group scored significantly higher on measures of self-reported depression, trauma-related dissociation, alcohol misuse, and social adjustment difficulties than did comparison groups. Importantly, difficulties with emotion regulation were found to partially mediate the relationship between PTSD and depression, poor social adjustment, and trauma-related depersonalization but not alcohol misuse. Emotion-regulation difficulties are important to consider in the relationship between PTSD and additional psychological outcomes in recently deployed personnel. Implications for treatment are briefly discussed. C1 [Mennin, Douglas S.] CUNY, Dept Psychol, Hunter Coll, New York, NY 10065 USA. [Klemanski, David H.] Yale Univ, Dept Psychol, New Haven, CT 06520 USA. [Borelli, Jessica L.] Pomona Coll, Dept Psychol, Claremont, CA 91711 USA. [Morrissey, Paul M.] USA, Mt Div LI 10, Ft Drum, NY USA. [Aikins, Deane E.] Yale Univ, Dept Psychiat, New Haven, CT 06520 USA. [Aikins, Deane E.] Natl Ctr Posttraumat Stress Disorder, West Haven, CT USA. RP Mennin, DS (reprint author), CUNY, Dept Psychol, Hunter Coll, 695 Pk Ave, New York, NY 10065 USA. EM dmennin@hunter.cuny.edu NR 60 TC 11 Z9 11 U1 3 U2 13 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1091-4269 J9 DEPRESS ANXIETY JI Depress. Anxiety PD JUL PY 2012 VL 29 IS 7 BP 621 EP 628 DI 10.1002/da.21914 PG 8 WC Psychology, Clinical; Psychiatry; Psychology SC Psychology; Psychiatry GA 967VP UT WOS:000305936200009 PM 22461455 ER PT J AU Opsenica, I Filipovic, V Nuss, JE Gomba, LM Opsenica, D Burnett, JC Gussio, R Solaja, BA Bavari, S AF Opsenica, Igor Filipovic, Vuk Nuss, Jon E. Gomba, Laura M. Opsenica, Dejan Burnett, James C. Gussio, Rick Solaja, Bogdan A. Bavari, Sina TI The synthesis of 2,5-bis(4-amidinophenyl)thiophene derivatives providing submicromolar-range inhibition of the botulinum neurotoxin serotype A metalloprotease SO EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY LA English DT Article DE Bioterrorism; Botulinum neurotoxin; Inhibition ID PROTEOLYTIC ACTIVITY; TOXIN; PHARMACOPHORE AB Botulinum neurotoxins (BoNTs), composed of a family of seven serotypes (categorized A-G), are the deadliest of known biological toxins. The activity of the metalloprotease, light chain (LC) component of the toxins is responsible for causing the life-threatening paralysis associated with the disease botulism. Herein we report significantly more potent analogs of novel, lead BoNT serotype A LC inhibitor 2,5-bis(4-amidinophenyl)thiophene (K-i = 10.881 mu M +/- 0.90 mu M). Specifically, synthetic modifications involved simultaneously replacing the lead inhibitor's terminal bis-amidines with secondary amines and the systematic tethering of 4-amino-7-chloroquinoline substituents to provide derivatives with K-i values ranging from 0.302 mu M (+/- 0.03 mu M) to 0.889 mu M (+/- 0.11 mu M). (C) 2012 Elsevier Masson SAS. All rights reserved. C1 [Opsenica, Igor; Filipovic, Vuk; Solaja, Bogdan A.] Univ Belgrade, Fac Chem, Belgrade, Serbia. [Nuss, Jon E.; Gomba, Laura M.] USA, Med Res Inst Infect Dis, Dept Bacteriol, Frederick, MD 21702 USA. [Opsenica, Dejan] Univ Belgrade, Inst Chem Technol & Met, Belgrade 11001, Serbia. [Burnett, James C.] SAIC Frederick Inc, Natl Canc Inst Frederick, Target Struct Based Drug Discovery Grp, Frederick, MD 21702 USA. [Gussio, Rick] NCI, Dev Therapeut Program, Frederick, MD 21702 USA. RP Solaja, BA (reprint author), Univ Belgrade, Fac Chem, Studentski Trg 16,POB 51, Belgrade, Serbia. EM burnettjames@mail.nih.gov; bsolaja@chem.bg.ac.rs; sina.bavari@us.army.mil RI Opsenica, Igor/P-5308-2016; OI Opsenica, Igor/0000-0003-4942-4042; Solaja, Bogdan/0000-0002-9975-2725 FU NATO's Public Diplomacy Division; National Institute of Allergy and Infectious Diseases (USA) [5-U01 AI082051-02]; National Cancer Institute; National Institutes of Health (USA) [HHSN261200800001E] FX This research was supported by NATO's Public Diplomacy Division in the framework of Science for Peace project SfP983638 and by National Institute of Allergy and Infectious Diseases (USA) grant 5-U01 AI082051-02.; Furthermore, for J.C.B., in compliance with SAIC-Frederick, Inc. contractual requirements: this project has been funded in whole or in part with federal funds from the National Cancer Institute, National Institutes of Health (USA), under Contract No. HHSN261200800001E. NR 29 TC 12 Z9 12 U1 0 U2 4 PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER PI PARIS PA 23 RUE LINOIS, 75724 PARIS, FRANCE SN 0223-5234 J9 EUR J MED CHEM JI Eur. J. Med. Chem. PD JUL PY 2012 VL 53 BP 374 EP 379 DI 10.1016/j.ejmech.2012.03.043 PG 6 WC Chemistry, Medicinal SC Pharmacology & Pharmacy GA 966UO UT WOS:000305863100040 PM 22516424 ER PT J AU Edupuganti, OP Ovsepian, SV Wang, JF Zurawski, TH Schmidt, JJ Smith, L Lawrence, GW Dolly, JO AF Edupuganti, Om P. Ovsepian, Saak V. Wang, Jiafu Zurawski, Tomas H. Schmidt, James J. Smith, Leonard Lawrence, Gary W. Dolly, J. Oliver TI Targeted delivery into motor nerve terminals of inhibitors for SNARE-cleaving proteases via liposomes coupled to an atoxic botulinum neurotoxin SO FEBS JOURNAL LA English DT Article DE biotin-streptavidin conjugation; neuromuscular transmission; pharmaceutical carriers; SNAP-25 ID DRUG-DELIVERY; NEUROTRANSMITTER RELEASE; GENE DELIVERY; BINDING; TOXIN; TRANSLOCATION; PROTEINS; AFFINITY; ENDINGS; NEURONS AB A targeted drug carrier (TDC) is described for transferring functional proteins or peptides into motor nerve terminals, a pivotal locus for therapeutics to treat neuromuscular disorders. It exploits the pronounced selectivity of botulinum neurotoxin type B (BoNT/B) for interacting with acceptors on these cholinergic nerve endings and becoming internalized. The gene encoding an innocuous BoNT/B protease-inactive mutant (BoTIM) was fused to that for core streptavidin, expressed in Escherichia coli and the purified protein was conjugated to surface-biotinylated liposomes. Such decorated liposomes, loaded with fluorescein as traceable cargo, acquired pronounced specificity for motor nerve terminals in isolated mouse hemidiaphragms and facilitated the intraneuronal transfer of the fluor, as revealed by confocal microscopy. Delivery of the protease light chain of botulinum neurotoxin type A (BoNT/A) via this TDC accelerated the onset of neuromuscular paralysis, indicative of improved translocation of this enzyme into the presynaptic cytosol with subsequent proteolytic inactivation of synaptosomal-associated protein of molecular mass 25 kDa (SNAP-25), an exocytotic soluble N-ethyl-maleimide-sensitive factor attachment protein receptor (SNARE) essential for neurotransmitter release. BoTIM-coupled liposomes, loaded with peptide inhibitors of proteases, yielded considerable attenuation of the neuroparalytic effects of BoNT/A or BoNT/F as a result of their cytosolic transfer, the first in situ demonstration of the ability of designer antiproteases to suppress the symptoms of botulism ex vivo. Delivery of the BoNT/A inhibitor by liposomes targeted with the full-length BoTIM proved more effective than that mediated by its C-terminal neuroacceptor-binding domain. This demonstrated versatility of TDC for nonviral cargo transfer into cholinergic nerve endings has unveiled its potential for direct delivery of functional targets into motor nerve endings. C1 [Edupuganti, Om P.; Ovsepian, Saak V.; Wang, Jiafu; Zurawski, Tomas H.; Lawrence, Gary W.; Dolly, J. Oliver] Dublin City Univ, Int Ctr Neurotherapeut, Dublin 9, Ireland. [Schmidt, James J.; Smith, Leonard] USA, Med Res Inst Infect Dis, Frederick, MD USA. RP Dolly, JO (reprint author), Dublin City Univ, Int Ctr Neurotherapeut, Dublin 9, Ireland. EM oliver.dolly@dcu.ie RI Dolly, Oliver/G-1532-2012 OI Dolly, Oliver/0000-0002-0861-5320 FU United States Defence Threat Reduction Agency [HDTRAI-07-C-0034, 3.10023_07_RD_B]; Science Foundation Ireland; Programme for Research in Third Level Institutions (PRTLI); European Regional Development Fund (ERDF), part of the European Union Structural Funds Programme FX We are grateful to Liam Ryan and Catherine Hagedorn for technical assistance. This work was supported by grants HDTRAI-07-C-0034 (to J.O.D.) and 3.10023_07_RD_B (to J.J.S.) from the United States Defence Threat Reduction Agency and a Research Professorship and Principal Investigator awards (to. J.O.D.) from Science Foundation Ireland. This work is funded under the Programme for Research in Third Level Institutions (PRTLI) Cycle 4. The PRTLI is co-funded through the European Regional Development Fund (ERDF), part of the European Union Structural Funds Programme 2007-2013. NR 48 TC 13 Z9 14 U1 0 U2 12 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1742-464X J9 FEBS J JI FEBS J. PD JUL PY 2012 VL 279 IS 14 BP 2555 EP 2567 DI 10.1111/j.1742-4658.2012.08638.x PG 13 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA 967KB UT WOS:000305905300008 PM 22607388 ER PT J AU Ziebarth, AJ Smith, H Killian, ME Nguyen, NA Durst, JK Subramaniam, A Kim, KH Leath, CA Straughn, JM Alvarez, RD AF Ziebarth, Angela J. Smith, Haller Killian, Mary E. Nguyen, Nguyet A. Durst, Jennifer K. Subramaniam, Akila Kim, Kenneth H. Leath, Charles A., III Straughn, J. Michael, Jr. Alvarez, Ronald D. TI Completed versus aborted radical hysterectomy for node-positive stage IB cervical cancer in the modern era of chemoradiation therapy SO GYNECOLOGIC ONCOLOGY LA English DT Article DE Cervical cancer; Vaginal brachytherapy; Stage I cervical cancer ID RADIATION-THERAPY; GYNECOLOGIC ONCOLOGY; SURGERY; INVOLVEMENT; CARCINOMA AB Objective. Debate continues about optimal management of patients with node-positive stage I cervical cancer. Our objective was to determine if patient outcomes are affected by radical hysterectomy in the modern era of adjuvant chemoradiation. Methods. Cervical cancer patients diagnosed from 2000 to 2008 were identified. Demographics, therapy, clinicopathologic data, progression free survival (PFS), overall survival (OS), total radiation exposure, and grade 3-4 complications were analyzed by student t, Mann-Whitney, Fisher's exact, Kaplan-Meier, and log rank tests. Results. This single-institution review evaluated forty-one of 334 (13.4%) patients scheduled to undergo radical hysterectomy that had gross nodal disease diagnosed intraoperatively. 15 underwent aborted radical hysterectomy following lymphadenectomy; the remaining 26 underwent radical hysterectomy and lymphadenectomy. Eleven patients undergoing radical hysterectomy underwent whole pelvic radiation therapy (WPRT) while 8 (30.7%) patients underwent WPRT and postoperative vaginal brachytherapy (BT) for local treatment secondary to close margins. All patients undergoing aborted radical hysterectomy underwent WPRT and BT. With mean follow-up of 42.3 months, there were no significant differences in urinary, gastrointestinal, or hematologic complications between groups. When comparing those undergoing radical hysterectomy to aborted radical hysterectomy, there were no significant differences in local recurrence (11.5% vs 26.7%, p = 039) or distant recurrence (19.2% vs. 33.3%, p = 0.45), PFS (74.9 months vs 46.8 months, p = 0.106), or OS (91.8 months vs 69.4 months, p = 0.886). Conclusions. Treatment of patients with early stage cervical cancer and nodal metastasis may be tailored intraoperatively. Completion of radical hysterectomy and lymphadenectomy decreases radiation exposure without apparently compromising safety or outcome in the era of adjuvant chemoradiation. (c) 2012 Elsevier Inc. All rights reserved. C1 [Ziebarth, Angela J.; Smith, Haller; Killian, Mary E.; Nguyen, Nguyet A.; Durst, Jennifer K.; Subramaniam, Akila; Kim, Kenneth H.; Straughn, J. Michael, Jr.; Alvarez, Ronald D.] Univ Alabama Birmingham, Birmingham, AL 35294 USA. [Leath, Charles A., III] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. RP Ziebarth, AJ (reprint author), Univ Alabama Birmingham, Birmingham, AL 35294 USA. EM aziebart@gmail.com OI Leath III, Charles/0000-0002-4034-6845; Subramaniam, Akila/0000-0003-0753-805X NR 14 TC 2 Z9 2 U1 0 U2 0 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0090-8258 J9 GYNECOL ONCOL JI Gynecol. Oncol. PD JUL PY 2012 VL 126 IS 1 BP 69 EP 72 DI 10.1016/j.ygyno.2012.03.046 PG 4 WC Oncology; Obstetrics & Gynecology SC Oncology; Obstetrics & Gynecology GA 967AL UT WOS:000305878400014 PM 22484400 ER PT J AU Veliadis, V Hearne, H Stewart, EJ Snook, M Chang, W Caldwell, JD Ha, HC El-Hinnawy, N Borodulin, P Howell, RS Urciuoli, D Lelis, A Scozzie, C AF Veliadis, Victor Hearne, H. Stewart, E. J. Snook, M. Chang, W. Caldwell, J. D. Ha, H. C. El-Hinnawy, N. Borodulin, P. Howell, R. S. Urciuoli, D. Lelis, A. Scozzie, C. TI Degradation and Full Recovery in High-Voltage Implanted-Gate SiC JFETs Subjected to Bipolar Current Stress SO IEEE ELECTRON DEVICE LETTERS LA English DT Article DE Annealing; basal plane dislocations (BPDs); bipolar current; high voltage; JFET; recovery; reliability; silicon carbide (SiC); stacking faults (SFs) ID STACKING-FAULTS; DIODES AB Electron-hole-recombination-induced stacking faults (SFs) have been shown to degrade the electrical characteristics of SiC power pin and MPS diodes and DMOSFETs with thick drift epitaxial layers. In this letter, we investigate the effects of bipolar current stress on the electrical characteristics of ion-implanted gate vertical-channel JFETs with 100-mu m drift epilayers. JFETs are stressed at a fixed gate-drain dc bipolar current density of 100 A/cm(2) for 5 h. Several JFETs exhibit severe forward gate-drain voltage degradation, while others show intermediate or no degradation. As degradation under bipolar current stress is caused by basal plane dislocation (BPD)-induced SF formation and expansion, the differences in degradation severity are attributed to the nonuniform BPD concentrations in the JFETs' drift epitaxial layers. Forward/reverse gate-source, transfer, reverse gate-drain, and blocking voltage JFET characteristics exhibit no degradation with bipolar stress. Forward gate-drain voltage and ON-state conduction degrade in affected JFETs. The degradations are fully reversed by annealing at 350 degrees C for 96 h, while nondegraded electrical characteristics remain unaffected by the annealing. These results suggest that elevated-temperature bipolar JFET operation can proceed without BPD-induced SF-related degradation. In the absence of BPDs, bipolar operation does not impact JFET electrical characteristics. C1 [Veliadis, Victor; Hearne, H.; Stewart, E. J.; Snook, M.; Ha, H. C.; El-Hinnawy, N.; Borodulin, P.; Howell, R. S.] Northrop Grumman Elect Syst, Linthicum, MD 21090 USA. [Chang, W.] MIT, Dept Elect Engn & Comp Sci, Cambridge, MA 02139 USA. [Caldwell, J. D.] USN, Res Lab, Washington, DC 20375 USA. [Urciuoli, D.; Lelis, A.; Scozzie, C.] USA, Res Lab, Adelphi, MD 20783 USA. RP Veliadis, V (reprint author), Northrop Grumman Elect Syst, Linthicum, MD 21090 USA. EM victor.veliadis@ngc.com; harold.hearne@ngc.com; eric.j.stewart@ngc.com; megan.snook@ngc.com; wchang7@u.rochester.edu; joshua.caldwell@nrl.navy.mil; hanh.ha@ngc.com; nabil.elhinnawy@ngc.com; pavel.borodulin@ngc.com; rs.howell@ngc.com; damian.p.urciuoli.civ@mail.mil; aivars.j.lelis@us.army.mil; charles.j.scozzie.civ@mail.mil RI Caldwell, Joshua/B-3253-2008 OI Caldwell, Joshua/0000-0003-0374-2168 FU U.S. Army Research Laboratory FX This work was supported by the U.S. Army Research Laboratory. The review of this letter was arranged by Editor S.-H. Ryu. NR 11 TC 5 Z9 5 U1 1 U2 8 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0741-3106 EI 1558-0563 J9 IEEE ELECTR DEVICE L JI IEEE Electron Device Lett. PD JUL PY 2012 VL 33 IS 7 BP 952 EP 954 DI 10.1109/LED.2012.2196674 PG 3 WC Engineering, Electrical & Electronic SC Engineering GA 966KA UT WOS:000305835300012 ER PT J AU Kim, S Zhang, X Daugherty, R Lee, E Kunnen, G Allee, DR Forsythe, E Chae, J AF Kim, Sangpyeong Zhang, Xu Daugherty, Robin Lee, Ed Kunnen, George Allee, David R. Forsythe, Eric Chae, Junseok TI Microelectromechanical Systems (MEMS) Based-Ultrasonic Electrostatic Actuators on a Flexible Substrate SO IEEE ELECTRON DEVICE LETTERS LA English DT Article DE Electrostatic actuator; microelectromechanical systems (MEMS); ultrasonic actuator ID HEARING-AIDS; TRANSDUCERS; LOUDSPEAKER; PERFORMANCE; COMPACT; SOUND AB We present a microelectromechanical systems (MEMS)-based electrostatic actuator on a flexible substrate, made of polyethylene naphthalate, which emits acoustic waves at ultrasonic frequencies. The actuator has a suspended diaphragm, made of parylene, of 2-6-mm diameter and a 6-mu m gap between the diaphragm and substrate. The actuator is driven by hydrogenated amorphous silicon integrated circuits. The driving circuits consist of voltage-controlled oscillator and buffer chain, which can tune the output voltage from 3 to 32 V with 35-V supply. A single actuator emits ultrasonic waves at 25 kHz and pressure of 27-dB sound pressure level (SPL), and a 1 x 2 array emits up to 34.6-dB SPL at 1-cm distance. C1 [Kim, Sangpyeong; Zhang, Xu; Daugherty, Robin; Lee, Ed; Kunnen, George; Allee, David R.; Chae, Junseok] Arizona State Univ, Dept Elect Engn, Tempe, AZ 85287 USA. [Forsythe, Eric] USA, Res Lab, Adelphi, MD 20783 USA. RP Kim, S (reprint author), Arizona State Univ, Dept Elect Engn, Tempe, AZ 85287 USA. EM skim85@asu.edu; Xu.Zhang.2@asu.edu; Robin.L.Daugherty@asu.edu; edward.lee@asu.edu; george.kunnen@gmail.com; allee@asu.edu; eric.forsythe@us.army.mil; Junseok.Chae@asu.edu FU Army Research Laboratory [W911NG-04-2-0005] FX This work was supported by the Army Research Laboratory under Cooperative Agreement W911NG-04-2-0005. The review of this letter was arranged by Editor A. Flewitt. NR 15 TC 1 Z9 1 U1 3 U2 22 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0741-3106 J9 IEEE ELECTR DEVICE L JI IEEE Electron Device Lett. PD JUL PY 2012 VL 33 IS 7 BP 1072 EP 1074 DI 10.1109/LED.2012.2195630 PG 3 WC Engineering, Electrical & Electronic SC Engineering GA 966KA UT WOS:000305835300052 ER PT J AU Tran, DT Dunbar, ZW Chu, D AF Tran, Dat T. Dunbar, Zachary W. Chu, Deryn TI Regenerable sulfur adsorbent for liquid phase JP-8 fuel using gold/silica based materials SO INTERNATIONAL JOURNAL OF HYDROGEN ENERGY LA English DT Article; Proceedings Paper CT 240th National Meeting of the American-Chemical-Society/Symposium on Hydrogen Production and Applications CY AUG 22-26, 2010 CL Boston, MA SP Amer Chem Soc DE Regenerable adsorbent; Fuel processing; JP-8 fuel; Logistical fuels; Gold/silica; Organic sulfur compounds ID ORGANOSULFUR COMPOUNDS; SELECTIVE ADSORPTION; HYDROGEN-PRODUCTION; JET FUEL; DESULFURIZATION; REMOVAL; ZEOLITES; CELLS AB Applications requiring hydrogen fuel, including portable, mobile and stationary fuel cells for power generation, are increasing. The conversion of JP-8 to hydrogen offers an energy dense feedstock for hydrogen production through fuel reformation. Unfortunately, organic sulfur compounds in logistical fuels, even at part per million levels, can poison reformer and fuel cell catalysts. In this work, adsorbents based on silica supported gold ions and gold nanoparticles were synthesized and evaluated for the adsorptive desulfurization of JP-8 jet fuel. The adsorbents were evaluated with JP-8 fuel containing 430 ppmw sulfur under ambient conditions. The preparation, as well as the sulfur removal and adsorption characteristics for two adsorbents are described in this work. Copyright (c) 2012, Hydrogen Energy Publications, LLC. Published by Elsevier Ltd. All rights reserved. C1 [Tran, Dat T.; Dunbar, Zachary W.; Chu, Deryn] USA, Res Lab, RDRL SED C, Adelphi, MD 20783 USA. RP Tran, DT (reprint author), USA, Res Lab, RDRL SED C, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM dat.t.tran4.civ@mail.mil NR 17 TC 10 Z9 10 U1 1 U2 23 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0360-3199 J9 INT J HYDROGEN ENERG JI Int. J. Hydrog. Energy PD JUL PY 2012 VL 37 IS 13 BP 10430 EP 10434 DI 10.1016/j.ijhydene.2012.01.115 PG 5 WC Chemistry, Physical; Electrochemistry; Energy & Fuels SC Chemistry; Electrochemistry; Energy & Fuels GA 969EP UT WOS:000306038800061 ER PT J AU Clifford, RJ Hang, J Riley, MC Onmus-Leone, F Kuschner, RA Lesho, EP Waterman, PE AF Clifford, Robert J. Hang, Jun Riley, Matthew C. Onmus-Leone, Fatma Kuschner, Robert A. Lesho, Emil P. Waterman, Paige E. TI Complete Genome Sequence of Providencia stuartii Clinical Isolate MRSN 2154 SO JOURNAL OF BACTERIOLOGY LA English DT Article ID BETA-LACTAMASE; AFGHANISTAN; BLA(NDM-1); RESISTANCE AB Here we present the complete genome sequence of Providencia stuartii MRSN 2154, isolated from an Afghan national. P. stuartii is a Gram-negative bacillus capable of causing infections in a wide variety of human tissues. Because Providencia readily acquires plasmids bearing drug resistance loci, it is of growing clinical significance. C1 [Clifford, Robert J.; Riley, Matthew C.; Onmus-Leone, Fatma; Lesho, Emil P.; Waterman, Paige E.] Walter Reed Army Inst Res, Multidrug Resistant Organism Surveillance Network, Silver Spring, MD USA. [Hang, Jun; Kuschner, Robert A.] Walter Reed Army Inst Res, Viral Dis Branch, Silver Spring, MD USA. RP Clifford, RJ (reprint author), Walter Reed Army Inst Res, Multidrug Resistant Organism Surveillance Network, Silver Spring, MD USA. EM robert.clifford@amedd.army.mil RI Valle, Ruben/A-7512-2013 FU U.S. Army Medical Command Policies [09-050, 11-035]; Global Emerging Infections Surveillance and Response System, a division of the Armed Forces Health Surveillance Center [C0709_12_WR, I0361_12_WR] FX This study was supported by the U.S. Army Medical Command Policies 09-050 and 11-035 and was partially funded by grants C0709_12_WR and I0361_12_WR from the Global Emerging Infections Surveillance and Response System, a division of the Armed Forces Health Surveillance Center. NR 16 TC 8 Z9 9 U1 1 U2 11 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0021-9193 J9 J BACTERIOL JI J. Bacteriol. PD JUL PY 2012 VL 194 IS 14 BP 3736 EP 3737 DI 10.1128/JB.00615-12 PG 2 WC Microbiology SC Microbiology GA 970AE UT WOS:000306099700025 PM 22740665 ER PT J AU Yang, B Irsa, J He, YP Lundgren, CA Zhao, YP AF Yang, B. Irsa, J. He, Y-P Lundgren, C. A. Zhao, Y-P TI A Chemo-Elastoplastic Analysis of Anisotropic Swelling in an SnO2 Nanowire Under Lithiation SO JOURNAL OF ENGINEERING MATERIALS AND TECHNOLOGY-TRANSACTIONS OF THE ASME LA English DT Article; Proceedings Paper CT ASME Applied Mechanics and Materials Conference (McMat) CY MAY 31-JUN 02, 2011 CL Chicago, IL SP ASME DE chemomechanics; diffusion induced stress; elastoplasticity; lithiation; lithium-ion battery; nanowires; strain hardening ratio; yield strength ID LITHIUM-ION BATTERIES; SILICON NANOWIRES; ELECTROCHEMICAL LITHIATION; HIGH-CAPACITY; ANODES; PERFORMANCE; TEMPERATURE AB A parametric study is carried out to shed light on the elastoplastic behavior of a nanowire under lithiation. The Li-ion diffusivity is assumed to be significantly higher at near-saturation than at dilute concentration. It leads to the prediction of an Li-ion diffusion jam and consequently a topologically steep step moving along the wire. The analysis shows that the different plastic flow rates due to the different constraint conditions along the longitudinal and radial directions result in apparent anisotropic volume expansion. Either lower yield strength, smaller strain hardening ratio, or higher charging rate would cause greater swelling anisotropy. The numerical results are compared with the experimental observation of an SnO2 nanowire (Huang et al., 2011, "In Situ Observation of the Electrochemical Lithiation of a Single SnO2 Nanowire Electrode," Science, 330, pp. 1515-1520) to suggest its elastoplastic properties under lithiation. [DOI:10.1115/1.4006502] C1 [Yang, B.] Univ Texas Arlington, Dept Mech & Aerosp Engn, Arlington, TX 76019 USA. [Irsa, J.] Univ Wyoming, Dept Geol & Geophys, Laramie, WY 82071 USA. [He, Y-P; Zhao, Y-P] Univ Georgia, Dept Phys & Astron, Nanoscale Sci & Engn Ctr, Athens, GA 30602 USA. [Lundgren, C. A.] USA, Res Lab, Adelphi, MD 20783 USA. RP Yang, B (reprint author), Univ Texas Arlington, Dept Mech & Aerosp Engn, Arlington, TX 76019 USA. EM boyang@uta.edu RI Zhao, Yiping/A-4968-2008; Yang, Bo/A-5716-2010; He, Yuping/F-2831-2011 NR 25 TC 0 Z9 0 U1 0 U2 17 PU ASME-AMER SOC MECHANICAL ENG PI NEW YORK PA THREE PARK AVE, NEW YORK, NY 10016-5990 USA SN 0094-4289 J9 J ENG MATER-T ASME JI J. Eng. Mater. Technol.-Trans. ASME PD JUL PY 2012 VL 134 IS 3 AR 031013 DI 10.1115/1.4006502 PG 5 WC Engineering, Mechanical; Materials Science, Multidisciplinary SC Engineering; Materials Science GA 966FF UT WOS:000305822300014 ER PT J AU Zhang, D Waas, AM Pankow, M Yen, CF Ghiorse, S AF Zhang, D. Waas, A. M. Pankow, M. Yen, C. F. Ghiorse, S. TI Flexural Behavior of a Layer-to-Layer Orthogonal Interlocked Three-Dimensional Textile Composite SO JOURNAL OF ENGINEERING MATERIALS AND TECHNOLOGY-TRANSACTIONS OF THE ASME LA English DT Article; Proceedings Paper CT ASME Applied Mechanics and Materials Conference (McMat) CY MAY 31-JUN 02, 2011 CL Chicago, IL SP ASME ID 3D WOVEN COMPOSITES; COMPRESSIVE FAILURE; FIBER COMPOSITES; STRENGTH; PREDICTION; MECHANISMS; DEGRADATION; FLOW AB The flexural response of a three-dimensional (3D) layer-to-layer orthogonal interlocked textile composite has been investigated under quasi-static three-point bending. Fiber tow kinking on the compressive side of the flexed specimens has been found to be a strength limiting mechanism for both warp and weft panels. The digital image correlation (DIC) technique has been utilized to map the deformation and identify the matrix microcracking on the tensile side prior to the peak load in the warp direction loaded panels. It has been shown that the geometrical characteristics of textile reinforcement play a key role in the mechanical response of this class of material. A 3D local-global finite element (FE) model that reflects the textile architectures has been proposed to successfully capture the surface strain localizations in the predamage region. To analyze the kink banding event, the fiber tow is modeled as an inelastic degrading homogenized orthotropic solid in a state of plane stress based on Schapery Theory (ST). The predicted peak stress is in agreement with the tow kinking stress obtained from the 3D FE model. [DOI:10.1115/1.4006501] C1 [Zhang, D.; Waas, A. M.; Pankow, M.] Univ Michigan, Dept Aerosp Engn, Composite Struct Lab, Ann Arbor, MI 48109 USA. [Pankow, M.] USA, Res Lab, Aberdeen, MD 21005 USA. [Yen, C. F.; Ghiorse, S.] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Waas, AM (reprint author), Univ Michigan, Dept Aerosp Engn, Composite Struct Lab, 1320 Beal St, Ann Arbor, MI 48109 USA. NR 27 TC 3 Z9 3 U1 1 U2 16 PU ASME-AMER SOC MECHANICAL ENG PI NEW YORK PA THREE PARK AVE, NEW YORK, NY 10016-5990 USA SN 0094-4289 J9 J ENG MATER-T ASME JI J. Eng. Mater. Technol.-Trans. ASME PD JUL PY 2012 VL 134 IS 3 AR 031009 DI 10.1115/1.4006501 PG 8 WC Engineering, Mechanical; Materials Science, Multidisciplinary SC Engineering; Materials Science GA 966FF UT WOS:000305822300010 ER PT J AU Teyhen, DS Childs, JD Stokes, MJ Wright, AC Dugan, JL George, SZ AF Teyhen, Deydre S. Childs, John D. Stokes, Maria J. Wright, Alison C. Dugan, Jessica L. George, Steven Z. TI Abdominal and Lumbar Multifidus Muscle Size and Symmetry at Rest and During Contracted States Normative Reference Ranges SO JOURNAL OF ULTRASOUND IN MEDICINE LA English DT Article DE external oblique; internal oblique; lumbar multifidus; morphology; morphometry; paraspinal musculature; rectus abdominis; transversus abdominis; ultrasound imaging ID LOW-BACK-PAIN; LEG RAISE TEST; POSTERIOR PELVIC PAIN; BODY-MASS INDEX; TRANSVERSUS ABDOMINIS; ULTRASOUND MEASUREMENT; WEIGHT-BEARING; MOTOR CONTROL; RELIABILITY; ACTIVATION AB Objectives-The purpose of this study was to establish reference values for abdominal and lumbar multifidus muscles at rest and while contracted in a sample of active healthy adults. Methods-Three hundred forty participants (mean age +/- SD, 21.8 +/- 3.9 years; 96 females and 244 males) completed the study. Ultrasound imaging was used to assess the thickness of the transversus abdominis, internal and external oblique, rectus abdominis, and lumbar multifidus muscles. Additionally, the cross-sectional area of the rectus abdominis was assessed. Results-Although males had significantly thicker muscles than females (P<.05), the relative change in thickness during specified tasks was equivalent. Overall, relative muscle thickness and symmetry were similar to previous studies using smaller sample sizes. Conclusions-These findings provide a robust data set of muscle thickness values measured by ultrasound imaging and can be used for comparison to those with pain, abnormal function, and pathologic conditions. C1 [Teyhen, Deydre S.; Childs, John D.; Wright, Alison C.; Dugan, Jessica L.] Baylor Univ, USA, Ft Sam Houston, TX USA. [Teyhen, Deydre S.] Publ Hlth Command Reg S, Ft Sam Houston, TX USA. [Childs, John D.] 81st Med Grp, Biloxi, MS USA. [Stokes, Maria J.] Univ Southampton, Southampton, Hants, England. [George, Steven Z.] Univ Florida, Gainesville, FL USA. RP Teyhen, DS (reprint author), USA, Dept Phys Therapy, Med Dept Ctr & Sch, Attn MCCS HGE PT, 3151 Scott Rd,Room 1303, Ft Sam Houston, TX 78234 USA. EM dteyhen@gmail.com FU US Department of Defense [PR054098]; Congressionally Directed Peer-Reviewed Medical Research Program, Ft Detrick, Maryland [W81XWH-06-1-0564] FX We thank CPT Nicole Hall, DPT, CPT Sonrie Gervacio, DPT, CPT Joseph Lopez, DPT, CPT Jason Mitchler; DPT, CPT Joshua Sorge, DPT, LT Michael Marmolejo, DPT, CPT Jeremy Mello, DPT, CPT Adam Taylor, DPT, LT Joshua Shumway, DPT, LT Brittany McCright, DPT, John May, DPT, Elizabeth Sampey, DPT, and Alexandria Gentles, DPT, for their contributions to image acquisition and measurement. We also thank the physical therapy students at the University of Texas Health Science Center for their support of this research study. The Prevention of Low Back Pain in the Military trial is supported by the peer-review medical research program of the US Department of Defense (PR054098), Congressionally Directed Peer-Reviewed Medical Research Program (W81XWH-06-1-0564), Ft Detrick, Maryland. The view(s) expressed herein are those of the author(s) and do not reflect the official policy or position of Brooke Army Medical Center, the US Army Medical Department, the US Army Office of the Surgeon General, the US Department of the Army, the US Department of Defense, or the US Government. NR 52 TC 11 Z9 12 U1 0 U2 7 PU AMER INST ULTRASOUND MEDICINE PI LAUREL PA SUBSCRIPTION DEPT, 14750 SWEITZER LANE, STE 100, LAUREL, MD 20707-5906 USA SN 0278-4297 J9 J ULTRAS MED JI J. Ultrasound Med. PD JUL PY 2012 VL 31 IS 7 BP 1099 EP 1110 PG 12 WC Acoustics; Radiology, Nuclear Medicine & Medical Imaging SC Acoustics; Radiology, Nuclear Medicine & Medical Imaging GA 969HU UT WOS:000306047100015 PM 22733859 ER PT J AU Pak, JH Lee, JH AF Pak, Jang Hyuk Lee, Joo Heon TI A hyper-concentrated sediment yield prediction model using sediment delivery ratio for large watersheds SO KSCE JOURNAL OF CIVIL ENGINEERING LA English DT Article DE sediment; fire; sediment delivery ratio; debris; watersheds ID FIRE; WILDFIRE AB This paper presents a sediment prediction model using sediment delivery ratio approach for prediction of sediment yields from large watersheds (larger than 800 ha). The Sediment Delivery Ratio (SDR) approach is effective for predicting the sediment yield as it moves through the stream system to a concentration point (debris basin) in the watershed. A statistical model, the Multi-Sequence Debris Prediction Model (MSDPM), was developed for use in relatively small watersheds (50-800 ha) in the Los Angeles area. In this study, the MSDPM was extended to include a sediment delivery ratio for modeling of sediment transport through the stream network in the large watershed. The sediment delivery ratio approach was implemented to express the percent of sediment yield that is delivered through a stream system from the sub-watersheds to the debris basin. After adding the sediment delivery ratio to estimate the sediment yields from large watersheds, the revised MSDPM (MSDPM-R) was calibrated and validated based on precipitation, sediment yield and fire data collected from the William Fire (September 2002) and Grand Prix Fire (October and November 2003) events in southern California. Results from MSDPM-R were compared with the available field data obtained from several debris basins within Los Angeles and San Bernardino Counties. The MSDPM-R yields remarkably consistent results when compared with the measured field data. C1 [Lee, Joo Heon] Joongbu Univ, Dept Civil Engn, Kumsan 312702, South Korea. [Pak, Jang Hyuk] US Army Corps Engn, Inst Water Resources, Hydrol Engn Ctr, Davis, CA 95616 USA. RP Lee, JH (reprint author), Joongbu Univ, Dept Civil Engn, Kumsan 312702, South Korea. EM jay.h.pak@usace.army.mil; leejh@joongbu.ac.kr NR 19 TC 0 Z9 0 U1 0 U2 6 PU KOREAN SOCIETY OF CIVIL ENGINEERS-KSCE PI SEOUL PA 50-7 OGUM-DONG, SONGPA-KU, SEOUL, 138-857, SOUTH KOREA SN 1226-7988 J9 KSCE J CIV ENG JI KSCE J. Civ. Eng. PD JUL PY 2012 VL 16 IS 5 BP 883 EP 891 DI 10.1007/s12205-012-1588-3 PG 9 WC Engineering, Civil SC Engineering GA 966JJ UT WOS:000305833600023 ER PT J AU Robb, ML Rerks-Ngarm, S Nitayaphon, S Pitisuttithum, P Kaewkungwal, J Kunasol, P Khamboonruang, C Thongcharoen, P Morgan, P Benenson, M Paris, RM Chiu, J Adams, E Francis, D Gurunathan, S Tartaglia, J Gilbert, P Stablein, D Michael, NL Kim, JH AF Robb, Merlin L. Rerks-Ngarm, Supachai Nitayaphon, Sorachai Pitisuttithum, Punnee Kaewkungwal, Jaranit Kunasol, Prayura Khamboonruang, Chirasak Thongcharoen, Prasert Morgan, Patricia Benenson, Michael Paris, Robert M. Chiu, Joseph Adams, Elizabeth Francis, Donald Gurunathan, Sanjay Tartaglia, Jim Gilbert, Peter Stablein, Don Michael, Nelson L. Kim, Jerome H. TI Risk behaviour and time as covariates for efficacy of the HIV vaccine regimen ALVAC-HIV (vCP1521) and AIDSVAX B/E: a post-hoc analysis of the Thai phase 3 efficacy trial RV 144 SO LANCET INFECTIOUS DISEASES LA English DT Article ID IMMUNODEFICIENCY-VIRUS; RHESUS-MONKEYS; INFECTION; MACAQUES; SIV; METAANALYSIS; REPLICATION; ACQUISITION; CHALLENGES; PREVENTION AB Background The Thai phase 3 HIV vaccine trial RV 144 showed modest efficacy of a vaccine against HIV acquisition. Baseline variables of age, sex, marital status, and risk did not modify vaccine efficacy. We did a post-hoc analysis of the trial's data to investigate behavioural risk and efficacy every 6 months after vaccination. Methods RV 144 was a randomised, multicentre, double-blind, placebo-controlled efficacy trial testing the combination of the HIV vaccines ALVAC-HIV (vCP1521) and AIDSVAX B/E to prevent HIV infection or reduce setpoint viral load. Male and female volunteers aged 18-30 years were recruited from the community. In this post-hoc analysis of the modified intention-to-treat population (16395 participants), HIV risk behaviour was assessed with a self-administered questionnaire at the time of initial vaccination in the trial and every 6 months thereafter for 3 years. We classified participants' behaviour as low, medium, or high risk. Both the acquisition endpoint and the early viral-load endpoint were examined for interactions with risk status over time and temporal effects after vaccination. Multiple proportional hazards regression models with treatment and time-varying risk covariates were analysed. Findings Risk of acquisition of HIV was low in each risk group, but 9187 (58.2%) participants reported higher-risk behaviour at least once during the study. Participants classified as high or increasing risk at least once during follow-up were compared with those who maintained low-risk or medium-risk behaviour as a time-varying covariate, and the interaction of risk status and acquisition efficacy was significant (p=0.01), with greater benefit in low-risk individuals. Vaccine efficacy seemed to peak early-cumulative vaccine efficacy was estimated to be 60.5% (95% CI 22-80) through the 12 months after initial vaccination-and declined quickly. Vaccination did not seem to affect viral load in either early or late infections. Interpretation Future HIV vaccine trials should recognise potential interactions between challenge intensity and risk heterogeneity in both population and treatment effects. The regimen tested in the RV 144 phase 3 trial might benefit from extended immunisation schedules. C1 [Robb, Merlin L.; Michael, Nelson L.; Kim, Jerome H.] Walter Reed Army Inst Res, Div Retrovirol, US Mil HIV Res Program, Rockville, MD USA. [Rerks-Ngarm, Supachai; Kunasol, Prayura; Khamboonruang, Chirasak; Thongcharoen, Prasert] Minist Publ Hlth, Dept Dis Control, Nonthaburi, Thailand. [Nitayaphon, Sorachai; Morgan, Patricia; Benenson, Michael] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Pitisuttithum, Punnee] Mahidol Univ, Vaccine Trials Ctr, Fac Trop Med, Bangkok 10700, Thailand. [Kaewkungwal, Jaranit] Mahidol Univ, Data Management Unit, Fac Trop Med, Bangkok 10700, Thailand. [Kaewkungwal, Jaranit] Henry Jackson Fdn, Rockville, MD USA. [Morgan, Patricia; Benenson, Michael] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [Paris, Robert M.] NIAID, NIH, Bethesda, MD 20892 USA. [Adams, Elizabeth] Global Solut Infect Dis, San Francisco, CA USA. [Francis, Donald] Sanofi Pasteur, Swiftwater, PA USA. [Gurunathan, Sanjay; Tartaglia, Jim] Fred Hutchinson Canc Res Ctr, Seattle, WA 98104 USA. [Gilbert, Peter] EMMES Corp, Rockville, MD USA. [Stablein, Don; Kim, Jerome H.] USA, Med Mat Dev Act, Ft Detrick, MD USA. RP Kim, JH (reprint author), 1600 E Gude Dr, Rockville, MD 20850 USA. EM jkim@hivresearch.org FU US National Institutes of Health, Division of AIDS; US Army Medical Research and Materiel Command; Division of AIDS, National Institute of Allergy and Infectious Disease, National Institutes of Health FX The study was funded by the US National Institutes of Health, Division of AIDS and the US Army Medical Research and Materiel Command. We recognise the crucial support and commitment of the volunteers, research staff, and communities of Chonburi and Rayong where the study was done. The opinions in this paper are those of the authors and are not to be construed as official and do not reflect the views of the Department of Army or the Department of Defense.; Funding US Army Medical Research and Materiel Command and Division of AIDS, National Institute of Allergy and Infectious Disease, National Institutes of Health. NR 27 TC 73 Z9 74 U1 0 U2 4 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1473-3099 J9 LANCET INFECT DIS JI Lancet Infect. Dis. PD JUL PY 2012 VL 12 IS 7 BP 531 EP 537 DI 10.1016/S1473-3099(12)70088-9 PG 7 WC Infectious Diseases SC Infectious Diseases GA 969HC UT WOS:000306045300026 PM 22652344 ER PT J AU Smith, TJ Marriott, BP Dotson, L Bathalon, GP Funderburk, L White, A Hadden, L Young, AJ AF Smith, Tracey J. Marriott, Bernadette P. Dotson, Laura Bathalon, Gaston P. Funderburk, LesLee White, Alan Hadden, Louise Young, Andrew J. TI Overweight and Obesity in Military Personnel: Sociodemographic Predictors SO OBESITY LA English DT Article ID WEIGHT-GAIN; US ADULTS; HEALTH; TRENDS; PREVALENCE AB In the United States, nationally representative civilian studies have shown that BMI is associated with select sociodemographic characteristics. Active-duty military personnel are not included in these surveys and the persistence of these associations in military personnel is unknown. Data from the worldwide, representative 2002 and 2005 Department of Defense (DoD) Surveys of Health-Related Behaviors Among Active Duty Military Personnel were used to assess the prevalence of overweight and obesity and, the association of BMI with sociodemographic characteristics. The final response bases included 12,756 (2002) and 16,146 (2005) personnel. Results indicated that the combined prevalence of overweight and obesity in military personnel increased to an all-time high in 2005 (60.5%) with higher prevalence of obesity in 2005 compared to 2002 (12.9% vs. 8.7, respectively, P <= 0.01). Holding other variables constant, regression analysis indicated that women were significantly less likely than men to be overweight or obese in both survey years (P <= 0.0001), which is contrary to civilian data. Similar to civilian data, the prevalence of obesity was significantly associated with increased age, black or Hispanic/Latino race/ethnicity, and being married (P <= 0.01). US military personnel are not immune to the US obesity epidemic. Demographic characteristics associated with being overweight should be considered when developing military-sponsored weight management programs. C1 [Smith, Tracey J.; Bathalon, Gaston P.; Funderburk, LesLee; Young, Andrew J.] USA, Mil Nutr Div, Environm Med Res Inst, Natick, MA 01760 USA. [Marriott, Bernadette P.; Dotson, Laura] Samueli Inst, Alexandria, VA USA. [Marriott, Bernadette P.; White, Alan] ABT Associates Inc, Durham, NC USA. [Marriott, Bernadette P.] Med Univ S Carolina, Dept Psychiat, Charleston, SC 29425 USA. [Hadden, Louise] ABT Associates Inc, Cambridge, MA 02138 USA. RP Smith, TJ (reprint author), USA, Mil Nutr Div, Environm Med Res Inst, Natick, MA 01760 USA. EM tracey.j.smith@us.army.mil FU US Army [W911QY-09-P-0082]; Abt Associates Inc. FX The analysis reported in this paper was supported in full by US Army Contract # W911QY-09-P-0082 with Abt Associates Inc. The authors are grateful to Janice Abbas and Viviane Enslein for preparation of the tables and formatting the final manuscript. NR 22 TC 31 Z9 33 U1 1 U2 4 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 1930-7381 J9 OBESITY JI Obesity PD JUL PY 2012 VL 20 IS 7 BP 1534 EP 1538 DI 10.1038/oby.2012.25 PG 5 WC Endocrinology & Metabolism; Nutrition & Dietetics SC Endocrinology & Metabolism; Nutrition & Dietetics GA 966LW UT WOS:000305840200030 PM 22314620 ER PT J AU Wall, WA Hoffmann, WA Wentworth, TR Gray, JB Hohmann, MG AF Wall, Wade A. Hoffmann, William A. Wentworth, Thomas R. Gray, Janet B. Hohmann, Matthew G. TI Demographic effects of fire on two endemic plant species in the longleaf pine-wiregrass ecosystem SO PLANT ECOLOGY LA English DT Article DE Astragalus; Demography; Endemism; Fire; Matrix models; Pinus palustris; Pyxidanthera ID EASTERN NORTH-AMERICA; POPULATION PROJECTION-MATRIX; ATLANTIC COASTAL-PLAIN; LAST GLACIAL MAXIMUM; PRESCRIBED FIRE; DYNAMICS; SEASON; SAVANNA; VIABILITY; GROWTH AB Fire can have dramatic effects on the vital rates of plant species and has been used successfully for management in a number of ecosystems. However, the demographic response of species to fire in fire-dependent ecosystems is variable, making it important to study the effects of fire on rare and threatened species. We quantified the effects of fire on Astragalus michauxii and Pyxidanthera brevifolia, two rare endemics of the longleaf pine-wiregrass ecosystem of the southeastern USA, by means of periodic matrix models to project the effect of fire frequency on population growth. In contrast to many species in the longleaf pine-wiregrass ecosystem, fire had short-term negative effects on both species, causing reductions in survival, size, flowering, and fruit production. Relative to the three-year fire intervals to which the study populations are currently exposed, more frequent burning is projected to cause population decline, with the most dramatic effects under annual burning. Although the current longleaf pine-wiregrass ecosystem is fire dependent and has experienced frequent fire for at least several thousand years, we propose that the two endemic species may be remnants from a past vegetation assemblage that experienced less frequent fire and thus may be adapted to longer fire-return intervals compared to other species currently in the ecosystem. Despite the short-term negative effects of fire on the vital rates of these species, longer-term benefits such as reduction of woody encroachment and litter removal may be important for the ultimate success of the species. C1 [Wall, Wade A.; Hohmann, Matthew G.] USA, Corps Engineers, Engineer Res & Dev Ctr, Champaign, IL 61826 USA. [Wall, Wade A.; Hoffmann, William A.; Wentworth, Thomas R.] N Carolina State Univ, Dept Plant Biol, Raleigh, NC 27695 USA. [Gray, Janet B.] Endangered Species Branch, Ft Bragg, NC 28310 USA. RP Wall, WA (reprint author), USA, Corps Engineers, Engineer Res & Dev Ctr, POB 9005, Champaign, IL 61826 USA. EM wawall@ncsu.edu RI Hoffmann, William/E-8894-2010 OI Hoffmann, William/0000-0002-1926-823X FU Construction Engineering Research Laboratory (US Army Corps of Engineers) [W9132T-07-2-0019]; North Carolina State University and its Plant Biology Department FX We thank Fort Bragg Military Reservation and the Endangered Species Branch for logistic support and the Construction Engineering Research Laboratory (US Army Corps of Engineers Agreement #W9132T-07-2-0019) for funding. We also thank Conseulo Arellano, Matthew Cleary, Brendan Dawal, Sherry Emerine, Will Fields, Kevin Gross, Jacob Hilton, Kristen Kostelnik, the North Carolina Natural Heritage Program, the North Carolina Botanical Garden, Renee Marchin, Eric Menges, Robert Peet, Bruce Sorrie, Andrew Walker, Alan Weakley, and the Hoffmann lab. We thank Rob Salguero-Gomez and two anonymous reviewers for their helpful comments. Finally, we thank North Carolina State University and its Plant Biology Department for financial support during the course of this study. NR 44 TC 6 Z9 6 U1 5 U2 119 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 1385-0237 J9 PLANT ECOL JI Plant Ecol. PD JUL PY 2012 VL 213 IS 7 BP 1093 EP 1104 DI 10.1007/s11258-012-0068-7 PG 12 WC Plant Sciences; Ecology; Forestry SC Plant Sciences; Environmental Sciences & Ecology; Forestry GA 968BQ UT WOS:000305952400004 ER PT J AU Sun, LT Friedrich, E Heuslein, JL Pferdehirt, RE Dangelo, NM Natesan, S Christy, RJ Washburn, NR AF Sun, Liang Tso Friedrich, Emily Heuslein, Joshua L. Pferdehirt, Rachel E. Dangelo, Nicole M. Natesan, Shanmugasundaram Christy, Robert J. Washburn, Newell R. TI Reduction of burn progression with topical delivery of (antitumor necrosis factor-alpha)-hyaluronic acid conjugates SO WOUND REPAIR AND REGENERATION LA English DT Article ID PARTIAL-THICKNESS BURNS; BLOOD MONONUCLEAR-CELLS; TNF-ALPHA CONTRIBUTES; THERMAL-INJURY; ISCHEMIA/REPERFUSION INJURY; ENDOTHELIAL PERMEABILITY; INTERLEUKIN-6 IL-6; EXPRESSION; CYTOKINE; DYSFUNCTION AB In this study, we explored whether topical application of antibodies targeting tumor necrosis factor-a (TNF-a) or interleukin-6 (IL-6) conjugated to hyaluronic acid (HA) could reduce the extension of necrosis by modulating inflammation locally in a partial-thickness rat burn model. Partial-thickness to deep partial-thickness burn injuries present significant challenges in healing, as these burns often progress following the initial thermal insult, resulting in necrotic expansion and increased likelihood of secondary complications. Necrotic expansion is driven by a microenvironment with elevated levels of pro-inflammatory mediators, and local neutralization of these using antibody conjugates could reduce burn progression. Trichrome-stained tissue sections indicated the least necrotic tissue in (anti-TNF-a)-HA-treated sites, while (anti-IL-6)-HA-treated sites displayed similar outcomes to saline controls. This was confirmed by vimentin immunostaining, which demonstrated that HA treatment alone reduced burn progression by nearly 30%, but (anti-TNF-a)-HA reduced it by approximately 70%. At all time points, (anti-TNF-a)-HA-treated sites showed reduced tissue levels of IL-1 beta compared to controls, suggesting inhibition of a downstream mediator of inflammation. Decreased macrophage infiltration in (anti-TNF-a)-HA-treated sites compared to controls was elucidated by immunohistochemical staining of macrophages, suggesting a reduction in overall inflammation in all time points. These results suggest that local targeting of TNF-a may be an effective strategy for preventing progression of partial-thickness burns. C1 [Sun, Liang Tso; Friedrich, Emily; Heuslein, Joshua L.; Washburn, Newell R.] Carnegie Mellon Univ, Dept Biomed Engn, Pittsburgh, PA 15213 USA. [Pferdehirt, Rachel E.; Dangelo, Nicole M.; Washburn, Newell R.] Carnegie Mellon Univ, Dept Chem, Pittsburgh, PA 15213 USA. [Natesan, Shanmugasundaram; Christy, Robert J.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Washburn, Newell R.] Univ Pittsburgh, McGowan Inst Regenerat Med, Pittsburgh, PA USA. RP Washburn, NR (reprint author), Carnegie Mellon Univ, Dept Biomed Engn, 4400 5th Ave, Pittsburgh, PA 15213 USA. EM washburn@andrew.cmu.edu FU Armed Forces Institute of Regenerative Medicine [W81XWH-08-2-0032]; National Institutes of Health [R43GM085897]; 3M Non-Tenured Faculty Grant; Wallace H. Coulter Foundation Translational Research Award program; Heinz Endowment [C1747]; Howard Hughes Medical Institute for support through the Undergraduate Science Education Program [CMU.52005865] FX The authors acknowledge support from the Armed Forces Institute of Regenerative Medicine (W81XWH-08-2-0032) and the National Institutes of Health (R43GM085897). NRW gratefully acknowledges support from a 3M Non-Tenured Faculty Grant, the Wallace H. Coulter Foundation Translational Research Award program, and the Heinz Endowment (C1747). REP and NMD wish to thank the Howard Hughes Medical Institute for support through the Undergraduate Science Education Program at CMU.52005865 The authors also wish to thank Dr. Yoram Vodovotz and Dr. Lillian Nanney for helpful discussions, and John Walters for help with statistical analysis. NR 48 TC 13 Z9 13 U1 0 U2 4 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1067-1927 J9 WOUND REPAIR REGEN JI Wound Repair Regen. PD JUL-AUG PY 2012 VL 20 IS 4 BP 563 EP 572 DI 10.1111/j.1524-475X.2012.00813.x PG 10 WC Cell Biology; Dermatology; Medicine, Research & Experimental; Surgery SC Cell Biology; Dermatology; Research & Experimental Medicine; Surgery GA 967HA UT WOS:000305896300014 PM 22712482 ER PT J AU Nguyen, AH Kim, S Maloney, WJ Wenke, JC Yang, Y AF Nguyen, A. H. Kim, S. Maloney, W. J. Wenke, J. C. Yang, Y. TI Effect of Coadministration of Vancomycin and BMP-2 on Cocultured Staphylococcus aureus and W-20-17 Mouse Bone Marrow Stromal Cells In Vitro SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY LA English DT Article ID INHIBITORY CONCENTRATION; MORPHOGENETIC PROTEIN-2; OPEN FRACTURES; GROWTH-FACTOR; OSTEOBLASTS; INFECTION; DELIVERY; OSTEOMYELITIS; INTERNALIZATION; ANTIBIOTICS AB In this study, we aimed to establish an in vitro bacterium/bone cell coculture model system and to use this model for dose dependence studies of dual administration of antibiotics and growth factors in vitro. We examined the effect of single or dual administration of the antibiotic vancomycin (VAN) at 0 to 16 mu g/ml and bone morphogenetic protein-2 (BMP-2) at 0 or 100 ng/ml on both methicillin-sensitive Staphylococcus aureus and mouse bone marrow stromal cells (W-20-17) under both mono- and coculture conditions. Cell metabolic activity, Live/Dead staining, double-stranded DNA (dsDNA) amounts, and alkaline phosphatase activity were measured to assess cell viability, proliferation, and differentiation. An interleukin-6 (IL-6) enzyme-linked immunosorbent assay (ELISA) kit was used to test the bone cell inflammation response in the presence of bacteria. Our results suggest that, when delivered together in coculture, VAN and BMP-2 maintain their primary functions as an antibiotic and a growth factor, respectively. Most interestingly, this dual-delivery type of approach has shown itself to be effective at lower concentrations of VAN than those required for an approach relying strictly on the antibiotic. It may be that BMP-2 enhances cell proliferation and differentiation before the cells become infected. In coculture, a dosage of VAN higher than that used for treatment in monoculture may be necessary to effectively inhibit growth of Staphylococcus aureus. This could mean that the coculture environment may be limiting the efficacy of VAN, possibly by way of bacterial invasion of the bone cells. This report of a coculture study demonstrates a potential beneficial effect of the coadministration of antibiotics and growth factors compared to treatment with antibiotic alone. C1 [Nguyen, A. H.; Kim, S.; Yang, Y.] Univ Texas Hlth Sci Ctr Houston, Dept Restorat Dent & Biomat, Houston, TX 77225 USA. [Kim, S.; Maloney, W. J.; Yang, Y.] Stanford Univ, Dept Orthoped Surg, Stanford, CA 94305 USA. [Wenke, J. C.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Yang, Y (reprint author), Univ Texas Hlth Sci Ctr Houston, Dept Restorat Dent & Biomat, Houston, TX 77225 USA. EM ypyang@stanford.edu FU DOD [W81XWH-10-1-0966, W81XWH-10-2-0010]; Airlift Research Foundation; Wallace H. Coulter Foundation; NIH from NIAMS [R01AR057837]; NIH from NIDCR [R01DE021468] FX We acknowledge the support from DOD (W81XWH-10-1-0966 and W81XWH-10-2-0010), Airlift Research Foundation, Wallace H. Coulter Foundation, NIH R01AR057837 from NIAMS, and NIH R01DE021468 from NIDCR. NR 50 TC 6 Z9 6 U1 0 U2 8 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0066-4804 J9 ANTIMICROB AGENTS CH JI Antimicrob. Agents Chemother. PD JUL PY 2012 VL 56 IS 7 BP 3776 EP 3784 DI 10.1128/AAC.00114-12 PG 9 WC Microbiology; Pharmacology & Pharmacy SC Microbiology; Pharmacology & Pharmacy GA 964DD UT WOS:000305673000042 PM 22564844 ER PT J AU Dai, TH Garcia, B Murray, CK Vrahas, MS Hamblin, MR AF Dai, Tianhong Garcia, Barbara Murray, Clinton K. Vrahas, Mark S. Hamblin, Michael R. TI UVC Light Prophylaxis for Cutaneous Wound Infections in Mice SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY LA English DT Article ID SOFT-TISSUE INFECTIONS; TARGETED PHOTODYNAMIC THERAPY; NO ESKAPE; IN-VIVO; SKIN; INACTIVATION; MILITARY; BACTERIA; AFGHANISTAN; PATHOGENS AB UVC light has long been known to be highly germicidal but has not been much developed as a therapy for infections. This study investigated the potential of UVC light for the prophylaxis of infections developing in highly contaminated superficial cutaneous wounds. In vitro studies demonstrated that the pathogenic bacteria Pseudomonas aeruginosa and Staphylococcus aureus were inactivated at UVC light exposures much lower than those needed for a similar effect on mammalian keratinocytes. Mouse models of partial-thickness skin abrasions infected with bioluminescent P. aeruginosa and S. aureus were developed. Approximately 10(7) bacterial cells were inoculated onto wounds measuring 1.2 by 1.2 cm on the dorsal surfaces of mice. UVC light was delivered at 30 min after bacterial inoculation. It was found that for both bacterial infections, UVC light at a single radiant exposure of 2.59 J/cm(2) reduced the bacterial burden in the infected mouse wounds by approximately 10-fold in comparison to those in untreated mouse wounds (P < 0.00001). Furthermore, UVC light increased the survival rate of mice infected with P. aeruginosa by 58.3% (P = 0.0023) and increased the wound healing rate in mice infected with S. aureus by 31.2% (P < 0.00001). DNA lesions were observed in the UVC light-treated mouse wounds; however, the lesions were extensively repaired by 48 h after UVC light exposure. These results suggested that UVC light may be used for the prophylaxis of cutaneous wound infections. C1 [Dai, Tianhong; Garcia, Barbara; Hamblin, Michael R.] Massachusetts Gen Hosp, Wellman Ctr Photomed, Boston, MA 02114 USA. [Dai, Tianhong; Garcia, Barbara; Hamblin, Michael R.] Harvard Univ, Sch Med, Dept Dermatol, Boston, MA 02115 USA. [Murray, Clinton K.] Brooke Army Med Ctr, Infect Dis Serv, Ft Sam Houston, TX 78234 USA. [Vrahas, Mark S.] Massachusetts Gen Hosp, Dept Orthopaed Surg, Boston, MA 02114 USA. [Hamblin, Michael R.] MIT, Harvard Mit Div Hlth Sci & Technol, Cambridge, MA 02139 USA. RP Hamblin, MR (reprint author), Massachusetts Gen Hosp, Wellman Ctr Photomed, Boston, MA 02114 USA. EM hamblin@helix.mgh.harvard.edu OI Hamblin, Michael/0000-0001-6431-4605 FU Airlift Research Foundation Extremity Trauma research grant [109421]; COTA/Smith Nephew grant [2012-16]; NIH [RO1AI050875] FX This study was supported in part by an Airlift Research Foundation Extremity Trauma research grant (109421 to T.D.), by a COTA/Smith & Nephew grant (2012-16 to T.D.), and by the NIH (grant RO1AI050875 to M.R.H.). We have no conflict of interest. NR 39 TC 11 Z9 11 U1 0 U2 6 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0066-4804 J9 ANTIMICROB AGENTS CH JI Antimicrob. Agents Chemother. PD JUL PY 2012 VL 56 IS 7 BP 3841 EP 3848 DI 10.1128/AAC.00161-12 PG 8 WC Microbiology; Pharmacology & Pharmacy SC Microbiology; Pharmacology & Pharmacy GA 964DD UT WOS:000305673000050 PM 22564833 ER PT J AU Kelley, AM Webb, CM Athy, JR Ley, S Gaydos, S AF Kelley, Amanda M. Webb, Catherine M. Athy, Jeremy R. Ley, Sanita Gaydos, Steven TI Cognition Enhancement by Modafinil: A Meta-Analysis SO AVIATION SPACE AND ENVIRONMENTAL MEDICINE LA English DT Article DE performance enhancement; pharmaceuticals; cognition ID SLEEP-DEPRIVATION; YOUNG VOLUNTEERS; PERFORMANCE; MOOD AB KELLEY AM, WEBB CM, ATHY JR, LEY S, GAYDOS S. Cognition enhancement by modafinil a meta-analysis. Aviat Space Environ Med 2012; 83:685-90. Introduction: Currently, there are a number of pharmaceuticals available that have potential to enhance cognitive functioning, some of which may ultimately be considered for such use in military operations. Some drugs with potential for cognition enhancement have already been studied for use in military operations specific to their primary effect in sleep regulation (i.e., dextroamphetamine, modafinil, caffeine). There is considerable information available on many of these drugs. However, considerations for military appropriateness must be based on proficient research (e.g., randomly controlled trial design). Methods: A meta-analysis was conducted to summarize the current state of knowledge of these potentially cognition-enhancing drugs. The analysis only included studies which met inclusion criteria relevant to military research. Results: The results of the literature review reveal a gap in research of the enhancement properties of the drugs of interest. The results yielded three studies (all of which studied modafinil) that met the criteria. The meta-analysis of these three studies revealed a relatively weak pooled effect of modafinil on some aspects of cognitive performance in normal, rested adults. Discussion: While the results of this study support the efficacy of modafinil, the main finding is the large literature gap evaluating the short- and long-term effects of these drugs in healthy adults. C1 [Kelley, Amanda M.; Webb, Catherine M.; Athy, Jeremy R.; Ley, Sanita; Gaydos, Steven] USA, Aeromed Res Lab, Ft Rucker, AL 36362 USA. RP Kelley, AM (reprint author), USA, Aeromed Res Lab, POB 620577, Ft Rucker, AL 36362 USA. EM amanda.m.kelley@us.army.mil NR 20 TC 9 Z9 9 U1 3 U2 23 PU AEROSPACE MEDICAL ASSOC PI ALEXANDRIA PA 320 S HENRY ST, ALEXANDRIA, VA 22314-3579 USA SN 0095-6562 J9 AVIAT SPACE ENVIR MD JI Aviat. Space Environ. Med. PD JUL PY 2012 VL 83 IS 7 BP 685 EP 690 DI 10.3357/ASEM.3212.2012 PG 6 WC Public, Environmental & Occupational Health; Medicine, General & Internal; Sport Sciences SC Public, Environmental & Occupational Health; General & Internal Medicine; Sport Sciences GA 966EJ UT WOS:000305820100009 PM 22779312 ER PT J AU Radoshitzky, SR Kuhn, JH de Kok-Mercado, F Jahrling, PB Bavari, S AF Radoshitzky, Sheli R. Kuhn, Jens H. de Kok-Mercado, Fabian Jahrling, Peter B. Bavari, Sina TI Drug discovery technologies and strategies for Machupo virus and other New World arenaviruses SO EXPERT OPINION ON DRUG DISCOVERY LA English DT Review DE antivirals; arenavirus; Machupo; therapeutics; viral hemorrhagic fever ID LYMPHOCYTIC CHORIOMENINGITIS VIRUS; ARGENTINE HEMORRHAGIC-FEVER; FINGER-Z-PROTEIN; STABLE SIGNAL PEPTIDE; VIRAL-RNA SYNTHESIS; REVERSE GENETICS GENERATION; I INTERFERON INDUCTION; PH-INDUCED ACTIVATION; ZINC-BINDING PROTEIN; GLYCOPROTEIN GP-C AB Introduction: Seven arenaviruses cause viral hemorrhagic fever in humans: the Old World arenaviruses Lassa and Lujo, and the New World Clade B arenaviruses Machupo (MACV), Junin (JUNV), Guanarito (GTOV), Sabia (SABV), and Chapare (CHPV). All of these viruses are Risk Group 4 biosafety pathogens. MACV causes human disease outbreak with high case-fatality rates. To date, at least 1,200 cases with approximate to 200 fatalities have been recorded. Areas covered: This review summarizes available systems and technologies for the identification of antivirals against MACV. Furthermore, the article summarizes animal models that have been used for the in vivo evaluation of novel inhibitors. The article highlights present treatments for arenaviral diseases and provides an overview of efficacious small molecules and other therapeutics reported to date. Finally, the article summarizes strategies to identify novel inhibitors for anti-arenaviral therapy. Expert opinion: New high-throughput approaches to quantitate infection rates of arenaviruses, as well as viruses modified to carry reporter genes, will accelerate compound screens and drug discovery efforts. RNAi, gene expression profiling and proteomics studies will identify host targets for therapeutic intervention. New discoveries in the cell entry mechanism of MACV and other arenaviruses as well as extensive structural studies of arenaviral L and NP could facilitate the rational design of antivirals effective against all pathogenic New World arenaviruses. C1 [Radoshitzky, Sheli R.; Bavari, Sina] USA, Med Res Inst Infect Dis, Frederick, MD 21702 USA. [Kuhn, Jens H.; de Kok-Mercado, Fabian; Jahrling, Peter B.] NIAID, Integrated Res Facil Ft Detrick, NIH, Frederick, MD 21702 USA. RP Bavari, S (reprint author), USA, Med Res Inst Infect Dis, Frederick, MD 21702 USA. EM sina.bavari@us.army.mil RI Kuhn, Jens H./B-7615-2011 OI Kuhn, Jens H./0000-0002-7800-6045 FU Joint Science and Technology Office Transformational Medical Technologies [TMTI0048_09_RDE_T]; NIAID [HHSN272200200016I] FX `SR Radoshitzky and S Bavari's research is supported by the Joint Science and Technology Office Transformational Medical Technologies (proposal #TMTI0048_09_RDE_T). F de Kok-Mercado performed this work as an employee of Battelle-Memorial Institute under its prime contract with NIAID (Contract No. HHSN272200200016I). JH Kuhn performed this work as an employee of Tunnell Consulting, Inc., a subcontractor to Battelle Memorial Institute under its prime contract with NIAID (Contract No. HHSN272200200016I). NR 207 TC 8 Z9 8 U1 2 U2 12 PU INFORMA HEALTHCARE PI LONDON PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND SN 1746-0441 J9 EXPERT OPIN DRUG DIS JI Expert. Opin. Drug Discov. PD JUL PY 2012 VL 7 IS 7 BP 613 EP 632 DI 10.1517/17460441.2012.687719 PG 20 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA 963WB UT WOS:000305654600007 PM 22607481 ER PT J AU Drost, RJ Singer, AC AF Drost, Robert J. Singer, Andrew C. TI Fast Recursive Equalizers for 1D and 2D Linear Equalization SO IEEE TRANSACTIONS ON SIGNAL PROCESSING LA English DT Article DE Channel equalization; intersymbol interference; recursive estimation; turbo equalization ID TURBO-EQUALIZATION; INTERSYMBOL INTERFERENCE; CODES; SYSTEMS AB We develop fast recursive equalizers to be used in the one-dimensional (1D) or two-dimensional (2D) linear minimum mean-squared error equalization of a known linear finite-length channel. In particular, these equalization algorithms address the communications scenario in which the channel or the prior information on the transmitted symbols may be time varying. The latter case of time-varying priors is especially pertinent for turbo equalization, on which we focus here. We first consider a 1D sliding-window equalizer based on a Cholesky-factorization update and then generalize this approach to the 2D case. Finally, we develop a 2D equalizer that is based on a recursive matrix-inverse update. We summarize each of these algorithms and describe their computational complexities. C1 [Drost, Robert J.] USA, Res Lab, Adelphi, MD 20783 USA. [Singer, Andrew C.] Univ Illinois, Dept Elect & Comp Engn, Urbana, IL 61801 USA. RP Drost, RJ (reprint author), USA, Res Lab, Adelphi, MD 20783 USA. EM robert.j.drost6.civ@mail.mil; acsinger@illinois.edu FU Department of the Navy, Office of Naval Research [N00014-01-1-0117]; National Science Foundation [CCR-0092598]; U.S. Army Research Laboratory FX This work was supported in part by the Department of the Navy, Office of Naval Research, under Grant N00014-01-1-0117, by the National Science Foundation under Grant CCR-0092598 (CAREER), and by an appointment to the U.S. Army Research Laboratory Postdoctoral Fellowship Program administered by the Oak Ridge Associated Universities through a contract with the U.S. Army Research Laboratory. NR 15 TC 0 Z9 0 U1 0 U2 3 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1053-587X EI 1941-0476 J9 IEEE T SIGNAL PROCES JI IEEE Trans. Signal Process. PD JUL PY 2012 VL 60 IS 7 BP 3886 EP 3891 DI 10.1109/TSP.2012.2191967 PG 6 WC Engineering, Electrical & Electronic SC Engineering GA 962WO UT WOS:000305578800049 ER PT J AU Grujicic, M Hariharan, A Pandurangan, B Yen, CF Cheeseman, BA Wang, Y Miao, Y Zheng, JQ AF Grujicic, M. Hariharan, A. Pandurangan, B. Yen, C. -F. Cheeseman, B. A. Wang, Y. Miao, Y. Zheng, J. Q. TI Fiber-Level Modeling of Dynamic Strength of Kevlar (R) KM2 Ballistic Fabric SO JOURNAL OF MATERIALS ENGINEERING AND PERFORMANCE LA English DT Article DE ballistic performance; flexible armor; Kevlar (R) KM2 fibers and fabric; penetration resistance ID FINITE-DEFORMATION THEORY; PLAIN-WEAVE FABRICS; MATRIX COMPOSITE ARMOR; WOVEN FABRICS; PROTECTION PERFORMANCE; MECHANICAL-PROPERTIES; TEXTILE COMPOSITES; ENERGY-ABSORPTION; ELEMENT MODEL; IMPACT AB In recent years, modeling of the high-performance ballistic fabric has gradually shifted from the continuum and yarn length scales to the sub-yarn length scale which enabled establishment of the relationships between the fabric penetration resistance and various fiber-level phenomena such as fiber-fiber friction, fiber twist, transverse properties of the fibers, and the stochastic nature of fiber strength. In general, these sub-yarn modeling schemes involve special numerical techniques (e. g., digital-element method) and customized computational codes. This status of the sub-yarn fabric-modeling methods and tools makes them not readily available to wider academic and industrial research communities. In the present work, an attempt is made to use conventional finite-element methods and tools in order to carry out sub-yarn numerical analysis of the penetration resistance of Kevlar (R) KM2 ballistic fabric. The goal was to demonstrate that results could be obtained which are comparable to their digital-element method = based counterparts. Specifically, a series of transient nonlinear dynamics finite-element analyses was carried out in order to investigate the role of the following two important sub-yarn phenomena on the penetration resistance of Kevlar (R) KM2 fabric: (a) fiber transverse properties including nonlinear elastic and plastic response and (b) fiber-fiber friction within the context of stochastically distributed fiber axial strength. It is generally found that the results obtained are consistent with their digital-element method-based counterparts. C1 [Grujicic, M.; Hariharan, A.; Pandurangan, B.] Clemson Univ, Dept Mech Engn, Clemson, SC 29634 USA. [Yen, C. -F.; Cheeseman, B. A.] USA, Res Lab, Survivabil Mat Branch, Aberdeen Proving Ground, MD 21005 USA. [Wang, Y.; Miao, Y.] Kansas State Univ, Dept Mech & Nucl Engn, Manhattan, KS 66506 USA. [Zheng, J. Q.] USA, PM Soldier Equipment, Haymarket, VA 20169 USA. RP Grujicic, M (reprint author), Clemson Univ, Dept Mech Engn, 241 Engn Innovat Bldg, Clemson, SC 29634 USA. EM gmica@clemson.edu FU Army Research Office (ARO) [W911NF-09-1-0513]; Army Research Laboratory (ARL) [W911NF-06-2-0042] FX The material presented in this article is based on work supported by the Army Research Office (ARO) research contract entitled "Multi-length Scale Material Model Development for Armor-grade Composites,'' Contract Number W911NF-09-1-0513, and the Army Research Laboratory (ARL) research contract entitled "Computational Analysis and Modeling of Various Phenomena Accompanying Detonation Explosives Shallow-Buried in Soil'' Contract Number W911NF-06-2-0042. NR 49 TC 13 Z9 13 U1 3 U2 25 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1059-9495 J9 J MATER ENG PERFORM JI J. Mater. Eng. Perform. PD JUL PY 2012 VL 21 IS 7 BP 1107 EP 1119 DI 10.1007/s11665-011-0006-1 PG 13 WC Materials Science, Multidisciplinary SC Materials Science GA 962EL UT WOS:000305522800001 ER PT J AU Allison, PG Horstemeyer, MF Brown, HR AF Allison, P. G. Horstemeyer, M. F. Brown, H. R. TI Modulus Dependence on Large Scale Porosity of Powder Metallurgy Steel SO JOURNAL OF MATERIALS ENGINEERING AND PERFORMANCE LA English DT Article DE carbon/alloy steels; mechanical testing; powder metallurgy ID ELASTIC-MODULI; COMPOSITE MATERIALS; DAMAGE AB This article compares the existing theoretical expressions for the porosity dependence on elastic constants to experimental data for a commercially available material, FC-0205 powder metallurgy (PM) steel. The modulus of compression, tension, effective torsion, and ultrasound-based data at varying porosity levels are plotted graphically against the theoretical expressions. An equation by McAdam (J. Iron Steel Inst. Lond., 1950, 168, p 346) was able to most accurately predict the experimental data with the adjustment of only one material constant. C1 [Allison, P. G.] USA, Corps Engineers, Geotech & Struct Lab, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. [Allison, P. G.; Horstemeyer, M. F.; Brown, H. R.] Mississippi State Univ, Dept Mech Engn, Mississippi State, MS 39762 USA. RP Allison, PG (reprint author), USA, Corps Engineers, Geotech & Struct Lab, Engineer Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM paul.g.allison@usace.army.mil OI Allison, Paul/0000-0002-9041-237X; Horstemeyer, Mark/0000-0003-4230-0063 FU U.S. Automotive Materials Partnership [AMD410, FC-26-02OR22910]; Center for Advanced Vehicular Systems at Mississippi State University FX This research was funded by the U.S. Automotive Materials Partnership (AMD410) contract no. FC-26-02OR22910 with guidance from Howard I. Sanderow (Center for Powder Metallurgy Technology-CPMT), Russell A. Chernenkoff (Metaldyne), Paulo Rosa (DaimlerChrysler), Shekhar G. Wakade (GM Powertrain), and Glen Weber (Ford Motor Company). The authors would also like to thank the Center for Advanced Vehicular Systems at Mississippi State University for supporting this study. The authors gratefully acknowledge the permission granted to publish this research article by the director of the Geotechnical and Structures Laboratory. NR 17 TC 3 Z9 3 U1 1 U2 1 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1059-9495 J9 J MATER ENG PERFORM JI J. Mater. Eng. Perform. PD JUL PY 2012 VL 21 IS 7 BP 1422 EP 1425 DI 10.1007/s11665-011-0001-6 PG 4 WC Materials Science, Multidisciplinary SC Materials Science GA 962EL UT WOS:000305522800040 ER PT J AU Kim, C McGlynn, KA McCorkle, R Li, YH Erickson, RL Ma, SG Niebuhr, DW Zhang, GS Zhang, YQ Bai, YN Dai, L Graubard, BI Zheng, TZ Aschebrook-Kilfoy, B Barry, KH Zhang, YW AF Kim, Christopher McGlynn, Katherine A. McCorkle, Ruth Li, Yonghong Erickson, Ralph L. Ma, Shuangge Niebuhr, David W. Zhang, Guangsheng Zhang, Yaqun Bai, Yana Dai, Li Graubard, Barry I. Zheng, Tongzhang Aschebrook-Kilfoy, Briseis Barry, Kathryn H. Zhang, Yawei TI Sexual functioning among testicular cancer survivors: A case-control study in the U.S. SO JOURNAL OF PSYCHOSOMATIC RESEARCH LA English DT Article DE Testicular cancer; Sexual function; Military men ID GERM-CELL TUMORS; LONG-TERM SURVIVORS; QUALITY-OF-LIFE; ERECTILE DYSFUNCTION; BODY-IMAGE; MEN; CHEMOTHERAPY; RISK; RADIOTHERAPY; FERTILITY AB Objective: Sexual function among testicular cancer survivors is a concern because affected men are of reproductive age when diagnosed. We conducted a case-control study among United States military men to examine whether testicular cancer survivors experienced impaired sexual function. Methods: A total of 246 testicular cancer cases and 236 ethnicity and age matched controls were enrolled in the study in 2008-2009. The Brief Male Sexual Function Inventory (BMSFI) was used to assess sexual function. Results: Compared to controls, cases scored significantly lower on sex drive (5.77 vs. 5.18), erection (9.40 vs. 8.63), ejaculation (10.83 vs. 9.90), and problem assessment (10.55 vs. 9.54). Cases were significantly more likely to have impaired erection (OR 1.72; 95% CI 1.11-2.64), ejaculation (OR 2.27; 95% CI 1.32-3.91), and problem assessment (OR 2.36; 95% CI 1.43-3.90). In histology and treatment analysis, nonseminoma, chemotherapy and radiation treated cases risk of erectile dysfunction, delayed ejaculation, and/or problem assessment were greater when compared to controls. Conclusion: This study provides evidence that testicular cancer survivors are more likely to have impaired sexual functioning compared to demographically matched controls. The observed impaired sexual functioning appeared to vary by treatment regimen and histologic subtype. (C) 2012 Elsevier Inc. All rights reserved. C1 [Kim, Christopher; Ma, Shuangge; Zheng, Tongzhang; Zhang, Yawei] Yale Univ, Sch Publ Hlth, New Haven, CT 06520 USA. [McGlynn, Katherine A.; Graubard, Barry I.; Aschebrook-Kilfoy, Briseis; Barry, Kathryn H.] NCI, Div Canc Epidemiol & Genet, NIH, US Dept HHS, Rockville, MD 20852 USA. [McCorkle, Ruth] Yale Univ, Sch Nursing, New Haven, CT 06520 USA. [Li, Yonghong; Zhang, Guangsheng] China CDC, Chinese Natl Inst Environm Hlth & Related Prod Sa, Beijing, Peoples R China. [Erickson, Ralph L.; Niebuhr, David W.] Walter Reed Army Inst Res, Forest Glen, MD USA. [Zhang, Yaqun] Gansu Prov Design & Res Inst Environm Sci, Lanzhou 730000, Gansu, Peoples R China. [Bai, Yana] Lanzhou Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Lanzhou 730000, Peoples R China. [Dai, Li] Sichuan Univ, Natl Ctr Birth Defect Monitoring, W China Univ Hosp 2, Chengdu 610041, Peoples R China. RP Zhang, YW (reprint author), Yale Univ, Sch Publ Hlth, 60 Coll St,LEPH 440, New Haven, CT 06520 USA. EM yawei.zhang@yale.edu FU National Cancer Institute (NCI) [CA105666, CA130110]; National Institute of Health (NIH) [1D43TW008323-01, 1D43TW007864-01]; CTSA from National Center for Research Resources (NCRR), a component of the NIH [UL1 RR024139] FX This study is supported by grants CA105666 and CA130110 from the National Cancer Institute (NCI) and by Fogarty training grants 1D43TW008323-01 and 1D43TW007864-01 from the National Institute of Health (NIH). This publication was made possible by CTSA Grant number UL1 RR024139 from the National Center for Research Resources (NCRR), a component of the NIH and NHL roadmap for medical Research. Its content is solely the responsibility of the authors and do not necessarily represent the official view of NCRR. The authors are greatly indebted to the Study participants, without whom, there would have been no study. NR 38 TC 9 Z9 9 U1 0 U2 8 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0022-3999 J9 J PSYCHOSOM RES JI J. Psychosomat. Res. PD JUL PY 2012 VL 73 IS 1 BP 68 EP 73 DI 10.1016/j.jpsychores.2012.02.011 PG 6 WC Psychiatry SC Psychiatry GA 965NX UT WOS:000305775600011 PM 22691563 ER PT J AU Trock, BJ Brotzman, MJ Mangold, LA Bigley, JW Epstein, JI McLeod, D Klein, EA Jones, JS Wang, SB McAskill, T Mehrotra, J Raghavan, B Partin, AW AF Trock, Bruce J. Brotzman, Michelle J. Mangold, Leslie A. Bigley, Joseph W. Epstein, Jonathan I. McLeod, David Klein, Eric A. Jones, J. Stephen Wang, Songbai McAskill, Theresa Mehrotra, Jyoti Raghavan, Bhargavi Partin, Alan W. TI Evaluation of GSTP1 and APC methylation as indicators for repeat biopsy in a high-risk cohort of men with negative initial prostate biopsies SO BJU INTERNATIONAL LA English DT Article DE prostate cancer; biopsy; methylation; APC; GSTP1 ID INTRAEPITHELIAL NEOPLASIA; PROMOTER METHYLATION; POSITIVE BIOPSIES; SEXTANT BIOPSIES; CANCER; ANTIGEN; PREDICTORS; HYPERMETHYLATION; ADENOCARCINOMA; CARCINOMA AB OBJECTIVE To evaluate the performance of DNA methylation biomarkers in the setting of repeat biopsy in men with an initially negative prostate biopsy but a high index of suspicion for missed prostate cancer. PATIENTS AND METHODS We prospectively evaluated 86 men with an initial histologically negative prostate biopsy and high-risk features. All men underwent repeat 12-core ultrasonography-guided biopsy. DNA methylation of glutathione-Stransferase P1 (GSTP1) and adenomatous polyposis coli (APC) was determined using tissue from the initially negative biopsy and compared with histology of the repeat biopsy. The primary outcome was the relative negative predictive value (NPV) of APC compared with GSTP1, and its 95% confidence interval (CI). RESULTS On repeat biopsy, 21/86 (24%) men had prostate cancer. APC and GSTP1 methylation ratios below the threshold (predicting no cancer) produced a NPV of 0.96 and 0.80, respectively. The relative NPV was 1.2 (95% CI: 1.06-1.36), indicating APC has significantly higher NPV. Methylation ratios above the threshold yielded a sensitivity of 0.95 for APC and 0.43 for GSTP1. Combining both methylation markers produced a performance similar to that of APC alone. APC methylation patterns were consistent with a possible field effect or occurrence early in carcinogenesis. CONCLUSIONS APC methylation provided a very high NPV with a low percentage of false-negatives, in the first prospective study to evaluate performance of DNA methylation markers in a clinical cohort of men undergoing repeat biopsy. The potential of APC methylation to reduce unnecessary repeat biopsies warrants validation in a larger prospective cohort. C1 [Trock, Bruce J.; Brotzman, Michelle J.; Mangold, Leslie A.; Partin, Alan W.] Johns Hopkins Sch Med, Brady Urol Inst, Baltimore, MD 21287 USA. [Bigley, Joseph W.; McAskill, Theresa] MDxHealth, Durham, NC USA. [Epstein, Jonathan I.] Johns Hopkins Sch Med, Dept Pathol, Baltimore, MD 21287 USA. [McLeod, David] Walter Reed Army Med Ctr, Dept Urol, Washington, DC 20307 USA. [Klein, Eric A.; Jones, J. Stephen] Cleveland Clin, Glickman Urol & Kidney Inst, Cleveland, OH 44106 USA. [Wang, Songbai; Mehrotra, Jyoti; Raghavan, Bhargavi] Johnson & Johnson, Orthoclin Diagnost, Raritan, NJ USA. RP Trock, BJ (reprint author), Johns Hopkins Sch Med, Brady Urol Inst, 600 N Wolfe St, Baltimore, MD 21287 USA. EM btrock@jhmi.edu FU MDx Health; Veridex, LLC; National Cancer Institute [P50-CA58236, U01-CA86323] FX Funding to conduct the study was provided by Veridex, LLC (now MDx Health). Alan W. Partin was a study investigator funded by Veridex, LLC. Source of funding: B.J.T. and A.W.P. were supported in part by funding from the National Cancer Institute, grant Nos. P50-CA58236 (SPORE in Prostate Cancer) and U01-CA86323 (Early Detection Research Network). NR 31 TC 37 Z9 39 U1 0 U2 8 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1464-4096 J9 BJU INT JI BJU Int. PD JUL PY 2012 VL 110 IS 1 BP 56 EP 62 DI 10.1111/j.1464-410X.2011.10718.x PG 7 WC Urology & Nephrology SC Urology & Nephrology GA 965CX UT WOS:000305744900013 PM 22077694 ER PT J AU Hancock, DE Indest, KJ Gust, KA Kennedy, AJ AF Hancock, Dawn E. Indest, Karl J. Gust, Kurt A. Kennedy, Alan J. TI Effects of C60 on the Salmonella typhimurium TA100 transcriptome expression: Insights into C60-mediated growth inhibition and mutagenicity SO ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY LA English DT Article DE Fullerenes; Mutagenicity; Transcriptomics ID FULLERENE WATER SUSPENSION; ENGINEERED NANOPARTICLES; OXIDATIVE STRESS; ANTIBACTERIAL ACTIVITY; SOLUBLE FULLERENES; C-60; EXPOSURE; DERIVATIVES; TOXICITY; MATTER AB Rapid advances are being made in the creation and use of nanomaterials, but little is known about the impact these materials might have on key microbial functions if introduced into the environment. Previous studies have generated conflicting results with respect to the impact of fullerenes on microbial activity. In the present study, Salmonella typhimurium TA100 was selected as a model microbial system with which to investigate further the impact of C60 aggregates on microbial growth, mutagenicity, and global transcript expression. Aggregates of C60 predominantly less than 100?nm significantly impacted Salmonella growth at concentrations of =0.5?mg/L. In addition, C60 aggregates also displayed mutagenic potential at concentrations =0.1?mg/L. Transcript expression analysis of S. typhimurium TA100 exposed to C60 for 24?h indicated that 271 transcripts had significant differential expression relative to controls with twofold or more change. Of particular interest was the increased expression of transcripts coding for proteins involved in energy metabolism, amino acid biosynthesis, transcription, and DNA metabolism, and the decreased expression of transcripts coding for proteins involved in protein fate, transport, and binding and bacterial secretion systems. Collectively, these data indicate that C60 interacts with the outer membrane of S. typhimurium TA100, resulting in delayed growth and mutagenicity, most likely by interfering with key transport functions and inducing a stress response, respectively. Environ. Toxicol. Chem. 2012; 31: 14381444. (C) 2012 SETAC C1 [Hancock, Dawn E.; Indest, Karl J.; Gust, Kurt A.; Kennedy, Alan J.] USA, Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS USA. RP Indest, KJ (reprint author), USA, Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS USA. EM karl.j.indest@usace.army.mil FU U.S. Army Corps of Engineers FX This research was funded through the U.S. Army Corps of Engineers Environmental Quality Program. Views, opinions, and/or findings contained herein are those of the authors and should not be construed as an official Department of the Army position or decision unless so designated by other official documentation. NR 50 TC 5 Z9 5 U1 1 U2 23 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0730-7268 J9 ENVIRON TOXICOL CHEM JI Environ. Toxicol. Chem. PD JUL PY 2012 VL 31 IS 7 BP 1438 EP 1444 DI 10.1002/etc.1848 PG 7 WC Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA 958ZS UT WOS:000305280100004 PM 22511527 ER PT J AU Bozue, J Cote, CK Webster, W Bassett, A Tobery, S Little, S Swietnicki, W AF Bozue, Joel Cote, Christopher K. Webster, Wendy Bassett, Anthony Tobery, Steven Little, Stephen Swietnicki, Wieslaw TI A Yersinia pestis YscN ATPase mutant functions as a live attenuated vaccine against bubonic plague in mice SO FEMS MICROBIOLOGY LETTERS LA English DT Article DE Yersinia pestis; YscN; plague; live vaccine ID RECOMBINANT V-ANTIGEN; III SECRETION ATPASE; TARGET-CELL CONTACT; PNEUMONIC PLAGUE; YOP SECRETION; ESCHERICHIA-COLI; PLASMINOGEN-ACTIVATOR; LOW-CA2+ RESPONSE; EFFECTOR PROTEINS; PASSIVE-IMMUNITY AB Yersinia pestis is the causative agent responsible for bubonic and pneumonic plague. The bacterium uses the pLcr plasmid-encoded type III secretion system to deliver virulence factors into host cells. Delivery requires ATP hydrolysis by the YscN ATPase encoded by the yscN gene also on pLcr. A yscN mutant was constructed in the fully virulent CO92 strain containing a nonpolar, in-frame internal deletion within the gene. We demonstrate that CO92 with a yscN mutation was not able to secrete the LcrV protein (V-Antigen) and attenuated in a subcutaneous model of plague demonstrating that the YscN ATPase was essential for virulence. However, if the yscN mutant was complemented with a functional yscN gene in trans, virulence was restored. To evaluate the mutant as a live vaccine, SwissWebster mice were vaccinated twice with the ?yscN mutant at varying doses and were protected against bubonic plague in a dose-dependent manner. Antibodies to F1 capsule but not to LcrV were detected in sera from the vaccinated mice. These preliminary results suggest a proof-of-concept for an attenuated, genetically engineered, live vaccine effective against bubonic plague. C1 [Bozue, Joel; Cote, Christopher K.; Webster, Wendy; Bassett, Anthony; Tobery, Steven; Little, Stephen; Swietnicki, Wieslaw] USA, Med Res Inst Infect Dis, Div Bacteriol, Ft Detrick, MD 21702 USA. RP Bozue, J (reprint author), USAMRIID, Bacteriol Div, 1425 Porter St, Ft Detrick, MD 21702 USA. EM joel.a.bozue@us.army.mil NR 61 TC 5 Z9 5 U1 0 U2 8 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0378-1097 EI 1574-6968 J9 FEMS MICROBIOL LETT JI FEMS Microbiol. Lett. PD JUL PY 2012 VL 332 IS 2 BP 113 EP 121 DI 10.1111/j.1574-6968.2012.02583.x PG 9 WC Microbiology SC Microbiology GA 959SW UT WOS:000305334300004 PM 22537022 ER PT J AU Alaro, JR Angov, E Lopez, AM Zhou, H Long, CA Burns, JM AF Alaro, James R. Angov, Evelina Lopez, Ana M. Zhou, Hong Long, Carole A. Burns, James M., Jr. TI Evaluation of the Immunogenicity and Vaccine Potential of Recombinant Plasmodium falciparum Merozoite Surface Protein 8 SO INFECTION AND IMMUNITY LA English DT Article ID APICAL MEMBRANE ANTIGEN-1; FACTOR-LIKE DOMAINS; MALARIA VACCINE; MONOCLONAL-ANTIBODY; TERMINAL FRAGMENT; ESCHERICHIA-COLI; DISULFIDE BONDS; INVASION; YOELII; IMMUNIZATION AB The C-terminal 19-kDa domain of merozoite surface protein 1 (MSP1(19)) is the target of protective antibodies but alone is poorly immunogenic. Previously, using the Plasmodium yoelii murine model, we fused P. yoelii MSP1(19) (PfMSP1(19)) with full-length P. yoelii merozoite surface protein 8 (MSP8). Upon immunization, the MSP8-restricted T cell response provided help for the production of high and sustained levels of protective PfMSP1(19)- and PyMSP8-specific antibodies. Here, we assessed the vaccine potential of MSP8 of the human malaria parasite, Plasmodium falciparum. Distinct from PfMSP8, P. falciparum MSP8 (PfMSP8) contains an N-terminal asparagine and aspartic acid (Asn/Asp)-rich domain whose function is unknown. Comparative analysis of recombinant full-length PfMSP8 and a truncated version devoid of the Asn/Asp-rich domain, PfMSP8(Delta Asn/Asp), showed that both proteins were immunogenic for T cells and B cells. All T cell epitopes utilized mapped within rPfMSP8(Delta Asn/Asp). The dominant B cell epitopes were conformational and common to both rPfMSP8 and rPfMSP8(Delta Asn/Asp). Analysis of native PfMSP8 expression revealed that PfMSP8 is present intracellularly in late schizonts and merozoites. Following invasion, PfMSP8 is found distributed on the surface of ring- and trophozoite-stage parasites. Consistent with a low and/or transient expression of PfMSP8 on the surface of merozoites, PfMSP8-specific rabbit IgG did not inhibit the in vitro growth of P. falciparum blood-stage parasites. These studies suggest that the further development of PfMSP8 as a malaria vaccine component should focus on the use of PfMSP8(Delta Asn/Asp) and its conserved, immunogenic T cell epitopes as a fusion partner for protective domains of poor immunogens, including PfMSP1(19). C1 [Alaro, James R.; Lopez, Ana M.; Long, Carole A.; Burns, James M., Jr.] Drexel Univ, Coll Med, Dept Microbiol & Immunol, Ctr Mol Parasitol, Philadelphia, PA 19104 USA. [Angov, Evelina] Walter Reed Army Inst Res, US Mil Malaria Res Program, Malaria Vaccine Branch, Silver Spring, MD USA. [Zhou, Hong; Long, Carole A.] NIAID, Malaria Immunol Sect, Lab Malaria & Vector Res, NIH, Rockville, MD USA. RP Burns, JM (reprint author), Drexel Univ, Coll Med, Dept Microbiol & Immunol, Ctr Mol Parasitol, Philadelphia, PA 19104 USA. EM jburns@drexelmed.edu FU NIH-NIAID [AI035661]; PATH Malaria Vaccine Initiative FX This work was supported by NIH-NIAID grant AI035661 (J.M.B.) and the Intramural Program of NIH-NIAID (C.A.L.).; We thank Kazutoyo Miura (NIH-NIAID) for providing the GIA data through the GIA Reference Center that is supported by the PATH Malaria Vaccine Initiative. We thank Prakash Srinivasan (NIH-NIAID) for assistance with the immunofluorescence analysis. NR 54 TC 4 Z9 5 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0019-9567 J9 INFECT IMMUN JI Infect. Immun. PD JUL PY 2012 VL 80 IS 7 BP 2473 EP 2484 DI 10.1128/IAI.00211-12 PG 12 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 963DD UT WOS:000305599400023 PM 22585960 ER PT J AU Phadikar, JK Bogetti, TA Karlsson, AM AF Phadikar, J. K. Bogetti, T. A. Karlsson, A. M. TI On establishing elastic-plastic properties of a sphere by indentation testing SO INTERNATIONAL JOURNAL OF SOLIDS AND STRUCTURES LA English DT Article DE Indentation; Spherical; Algorithms; Elastic moduli; Yield ID RESIDUAL-STRESS; MECHANICAL-PROPERTIES; CONICAL INDENTATION; RIGID FLAT; FINITE-ELEMENT; CONTACT; NANOINDENTATION; COMPRESSION; BEHAVIOR; HARDNESS AB Instrumented indentation is a popular technique for determining mechanical properties of materials. Currently, the evaluation techniques of instrumented indentation are mostly limited to a flat substrate being indented by various shaped indenters (e.g., conical or spherical). This work investigates the possibility of extending instrumented indentation to non-flat surfaces. To this end, conical indentation of a sphere is investigated where two methodologies for establishing mechanical properties are explored. In the first approach, a semi-analytical approach is employed to determine the elastic modulus of the sphere utilizing the elastic unloading response (the "unloading slope"). In the second method, reverse analysis based on finite element analysis is used, where non-dimensional characteristic functions derived from the force-displacement response are utilized to determine the elastic modulus and yield strength. To investigate the accuracies of the proposed methodologies, selected numerical experiments have been performed and excellent agreement was obtained. (C) 2012 Elsevier Ltd. All rights reserved. C1 [Phadikar, J. K.; Karlsson, A. M.] Univ Delaware, Dept Mech Engn, Newark, DE 19716 USA. [Bogetti, T. A.] USA, Res Lab, Aberdeen Proving Ground, MD USA. RP Karlsson, AM (reprint author), Univ Delaware, Dept Mech Engn, Newark, DE 19716 USA. EM karlsson@udel.edu NR 35 TC 2 Z9 2 U1 5 U2 28 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0020-7683 J9 INT J SOLIDS STRUCT JI Int. J. Solids Struct. PD JUL PY 2012 VL 49 IS 14 BP 1961 EP 1972 DI 10.1016/j.ijsolstr.2012.04.001 PG 12 WC Mechanics SC Mechanics GA 961CN UT WOS:000305441600004 ER PT J AU Wright, KM Foran, HM Wood, MD Eckford, RD McGurk, D AF Wright, Kathleen M. Foran, Heather M. Wood, Michael D. Eckford, Rachel D. McGurk, Dennis TI Alcohol Problems, Aggression, and Other Externalizing Behaviors After Return From Deployment: Understanding the Role of Combat Exposure, Internalizing Symptoms, and Social Environment SO JOURNAL OF CLINICAL PSYCHOLOGY LA English DT Article DE externalizing behaviors; military personnel; aggression; alcohol problems; combat exposure ID POSTTRAUMATIC-STRESS-DISORDER; MENTAL-HEALTH PROBLEMS; COVARIANCE STRUCTURE-ANALYSIS; AFGHANISTAN WAR VETERANS; MISSING DATA; RISK-TAKING; TRAUMATIC EVENTS; SUBSTANCE USE; PRIMARY-CARE; DSM-V AB Objectives The study examined whether elevated rates of externalizing behaviors following deployment could be explained by internalizing symptoms (depression, anxiety, and PTSD symptoms), and health of the social environment (unit leadership, organizational support, and stigma/barriers to care). Design A model of combat exposure, social environment, internalizing symptoms, and externalizing behaviors was tested in a military unit following a fifteen-month deployment to Iraq. The sample included 1,397 soldiers assessed four month post-deployment; 589 of these soldiers were assessed again nine months post-deployment. Results Externalizing behaviors were highly stable over the five-month post-deployment period. Both social environment and internalizing symptoms were significantly associated with level of externalizing behaviors at four months and nine months post-deployment, but combat exposure alone significantly predicted change in externalizing behaviors over the follow-up period. Conclusions Results suggest the need to broaden the scope of interventions targeted to combat veterans and have implications for care providers and military leaders. (c) 2012 Wiley Periodicals, Inc. J. Clin. Psychol. 68:782-800, 2012 C1 [Wright, Kathleen M.; Foran, Heather M.; Wood, Michael D.; Eckford, Rachel D.] USA, Med Res Unit Europe, Walter Reed Army Inst Res, Heidelberg, Germany. [McGurk, Dennis] Walter Reed Army Inst Res, Silver Spring, MD USA. RP Wright, KM (reprint author), USA, Med Res Unit, APO, AE 09042 USA. EM kathleen.wright@us.army.mil NR 76 TC 16 Z9 16 U1 2 U2 23 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0021-9762 J9 J CLIN PSYCHOL JI J. Clin. Psychol. PD JUL PY 2012 VL 68 IS 7 BP 782 EP 800 DI 10.1002/jclp.21864 PG 19 WC Psychology, Clinical SC Psychology GA 959DV UT WOS:000305293300006 PM 22573513 ER PT J AU Scott, AM Petrova, T Odbadrakh, K Nicholson, DM Fuentes-Cabrera, M Lewis, JP Hill, FC Leszczynski, J AF Scott, Andrea Michalkova Petrova, Tetyana Odbadrakh, Khorgolkhuu Nicholson, Donald M. Fuentes-Cabrera, Miguel Lewis, James P. Hill, Frances C. Leszczynski, Jerzy TI Molecular simulations of adsorption of RDX and TATP on IRMOF-1(Be) SO JOURNAL OF MOLECULAR MODELING LA English DT Article DE Adsorption; B97-D; IRMOF-1; RDX; TATP ID METAL-ORGANIC FRAMEWORKS; AB-INITIO; PYRIDINE ADSORPTION; ELECTRON-DENSITY; HYDROGEN STORAGE; CLAY-MINERALS; MOF-5; SITES; MECHANISM; SURFACE AB The influence of different sorption sites of isoreticular metal-organic frameworks (IRMOFs) on interactions with explosive molecules is investigated. Different connector effects are taken into account by choosing IRMOF-1(Be) (IRMOF-1 with Zn replaced by Be), and two high explosive molecules: 1,3,5-trinitro-s-triazine (RDX) and triacetone triperoxide (TATP). The key interaction features (structural, electronic and energetic) of selected contaminants were analyzed by means of density functional calculations. The interaction of RDX and TATP with different IRMOF-1(Be) fragments is studied. The results show that physisorption is favored and occurs due to hydrogen bonding, which involves the C-H groups of both molecules and the carbonyl oxygen atoms of IRMOF-1(Be). Additional stabilization of RDX and TATP arises from weak electrostatic interactions. Interaction with IRMOF-1(Be) fragments leads to polarization of the target molecules. Of the molecular configurations we have studied, the Be-O-C cluster connected with six benzene linkers (1,4-benzenedicarboxylate, BDC), possesses the highest binding energy for the studied explosives (-16.4 kcal mol(-1) for RDX and -12.9 kcal mol(-1) for TATP). The main difference was discovered to be in the preferable adsorption site for adsorbates (RDX above the small and TATP placed above the big cage). Based on these results, IRMOF-1 can be suggested as an effective material for storage and also for separation of similar explosives. Hydration destabilizes most of the studied adsorption systems by 1-3 kcal mol(-1) but it leads to the same trend in the binding strength as found for the non-hydrated complexes. C1 [Scott, Andrea Michalkova; Hill, Frances C.] USA, ERDC, Vicksburg, MS 39180 USA. [Scott, Andrea Michalkova; Petrova, Tetyana; Leszczynski, Jerzy] Jackson State Univ, Dept Chem, Interdisciplinary Nanotox Ctr, Jackson, MS 39217 USA. [Odbadrakh, Khorgolkhuu] ORNL, Mat Sci & Technol Div, Oak Ridge, TN 37831 USA. [Nicholson, Donald M.; Fuentes-Cabrera, Miguel] Oak Ridge Natl Lab, Ctr Nanophase Mat Sci, Oak Ridge, TN 37831 USA. [Lewis, James P.] W Virginia Univ, Dept Phys & Astron, Morgantown, WV 26506 USA. [Nicholson, Donald M.; Fuentes-Cabrera, Miguel] Oak Ridge Natl Lab, Div Math & Comp Sci, Oak Ridge, TN 37831 USA. RP Scott, AM (reprint author), USA, ERDC, Vicksburg, MS 39180 USA. EM andrea@icnanotox.org RI Fuentes-Cabrera, Miguel/Q-2437-2015 OI Fuentes-Cabrera, Miguel/0000-0001-7912-7079 FU NSF grant EXP-LA [0730186] FX This work was facilitated by the NSF grant EXP-LA no. 0730186. Work at ORNL was performed under the auspices of the Division of Materials Science and Engineering, Office of Basic Energy Science of the US Department of Energy. The use of trade, product, or firm names in this report is for descriptive purposes only and does not imply endorsement by the U.S. Government. The tests described and the resulting data presented herein, unless otherwise noted, were obtained from research conducted under the Environmental Quality Technology Program of the United States Army Corps of Engineers by the United States Army Engineer Research and Development Center (USAERDC). Permission was granted by the Chief of Engineers to publish this information. The findings of this report are not to be construed as an official Department of the Army position unless so designated by other authorized documents. NR 76 TC 7 Z9 7 U1 2 U2 38 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1610-2940 J9 J MOL MODEL JI J. Mol. Model. PD JUL PY 2012 VL 18 IS 7 BP 3363 EP 3378 DI 10.1007/s00894-011-1338-3 PG 16 WC Biochemistry & Molecular Biology; Biophysics; Chemistry, Multidisciplinary; Computer Science, Interdisciplinary Applications SC Biochemistry & Molecular Biology; Biophysics; Chemistry; Computer Science GA 963EM UT WOS:000305602900044 PM 22271094 ER PT J AU Dirks, MS Butman, JA Kim, HJ Wu, TX Morgan, K Tran, AP Lonser, RR Asthagiri, AR AF Dirks, Michael S. Butman, John A. Kim, H. Jeffrey Wu, Tianxia Morgan, Keaton Tran, Anne P. Lonser, Russell R. Asthagiri, Ashok R. TI Natural history of neurofibromatosis Type 2 tumors Response SO JOURNAL OF NEUROSURGERY LA English DT Editorial Material C1 [Dirks, Michael S.; Morgan, Keaton; Tran, Anne P.; Lonser, Russell R.; Asthagiri, Ashok R.] NINDS, Surg Neurol Branch, Bethesda, MD 20892 USA. [Wu, Tianxia] NINDS, Clin Neurosci Program, Bethesda, MD 20892 USA. [Butman, John A.] NIH, Dept Diagnost Radiol, Ctr Clin, Bethesda, MD 20892 USA. [Kim, H. Jeffrey] Natl Inst Deafness & Other Commun Disorders, Head & Neck Surg Branch, NIH, Bethesda, MD USA. [Dirks, Michael S.] Walter Reed Army Med Ctr, Dept Neurol Surg, Washington, DC 20307 USA. RP Dirks, MS (reprint author), NINDS, Surg Neurol Branch, Bldg 36,Rm 4D04, Bethesda, MD 20892 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC NEUROLOGICAL SURGEONS PI ROLLING MEADOWS PA 5550 MEADOWBROOK DRIVE, ROLLING MEADOWS, IL 60008 USA SN 0022-3085 J9 J NEUROSURG JI J. Neurosurg. PD JUL PY 2012 VL 117 IS 1 BP 108 EP 108 PG 1 WC Clinical Neurology; Surgery SC Neurosciences & Neurology; Surgery GA 962ZC UT WOS:000305588900020 ER PT J AU Dirks, MS Butman, JA Kim, HJ Wu, TX Morgan, K Tran, AP Lonser, RR Asthagiri, AR AF Dirks, Michael S. Butman, John A. Kim, H. Jeffrey Wu, Tianxia Morgan, Keaton Tran, Anne P. Lonser, Russell R. Asthagiri, Ashok R. TI Long-term natural history of neurofibromatosis Type 2-associated intracranial tumors Clinical article SO JOURNAL OF NEUROSURGERY LA English DT Article DE neurofibromatosis Type 2; intracranial tumor; natural history; vestibular schwannoma; meningioma; tumor growth; oncology ID VESTIBULAR SCHWANNOMA GROWTH; HIPPEL-LINDAU-DISEASE; STEREOTACTIC RADIOSURGERY; ACOUSTIC NEUROMAS; HUMAN MENINGIOMAS; PROGESTERONE; RECEPTORS; RATES; HEMANGIOBLASTOMAS; PREDICTORS AB Object. Neurofibromatosis Type 2 (NF2) is a heritable tumor predisposition syndrome that leads to the development of multiple intracranial tumors, including meningiomas and schwannomas. Because the natural history of these tumors has not been determined, their optimal management has not been established. To define the natural history of NF2-associated intracranial tumors and to optimize management strategies, the authors evaluated long-term clinical and radiographic data in patients with NF2. Methods. Consecutive NF2 patients with a minimum of 4 years of serial clinical and MRI follow-up were analyzed. Results. Seventeen patients, 9 males and 8 females, were included in this analysis (mean follow-up 9.5 +/- 4.8 years, range 4.0-20.7 years). The mean age at initial evaluation was 33.2 +/- 15.5 years (range 12.3-57.6 years). Patients harbored 182 intracranial neoplasms, 164 of which were assessable for growth rate analysis (18 vestibular schwannomas [VSs], 11 nonvestibular cranial nerve [CN] schwannomas, and 135 meningiomas) and 152 of which were assessable for growth pattern analysis (15 VSs, 9 nonvestibular CN schwannomas, and 128 meningiomas). New tumors developed in patients over the course of the imaging follow-up: 66 meningiomas, 2 VSs, and 2 nonvestibular CN schwannomas. Overall, 45 tumors (29.6%) exhibited linear growth, 17 tumors (11.2%) exhibited exponential growth, and 90 tumors (59.2%) displayed a saltatory growth pattern characterized by alternating periods of growth and quiescence (mean quiescent period 2.3 +/- 2.1 years, range 0.4-11.7 years). Further, the saltatory pattern was the most frequently identified growth pattern for each tumor type: meningiomas 60.9%. VSs 46.7%, and nonvestibular schwannoma 55.6%. A younger age at the onset of NF2-related symptoms (p = 0.01) and female sex (p = 0.05) were associated with an increased growth rate in meningiomas. The identification of saltatory growth in meningiomas increased with the duration of follow-up (p = 0.01). Conclusions. Neurofibromatosis Type 2 associated intracranial tumors most frequently demonstrated a saltatory growth pattern. Because new tumors can develop in NF2 patients over their lifetime and because radiographic progression and symptom formation are unpredictable, resection may be best reserved for symptom-producing tumors. Moreover, establishing the efficacy of nonsurgical therapeutic interventions must be based on long-term follow-up (several years). (http:://thejns.org/doi/abs/10.3171/2012.3.JNS111649) C1 [Asthagiri, Ashok R.] NINDS, Surg Neurol Branch, NIH, Bethesda, MD 20892 USA. [Wu, Tianxia] NINDS, Clin Neurosci Program, Bethesda, MD 20892 USA. [Butman, John A.] NIH, Dept Diagnost Radiol, Ctr Clin, Bethesda, MD 20892 USA. [Kim, H. Jeffrey] Natl Inst Deafness & Other Commun Disorders, Head & Neck Surg Branch, NIH, Bethesda, MD USA. [Dirks, Michael S.] Walter Reed Army Med Ctr, Dept Neurol Surg, Washington, DC 20307 USA. RP Asthagiri, AR (reprint author), NINDS, Surg Neurol Branch, NIH, Bldg 10,Room 3D20, Bethesda, MD 20892 USA. EM asthagiria@ninds.nih.gov RI Butman, John/J-2780-2013 OI Butman, John/0000-0002-1547-9195 FU National Institute of Neurologic Disorders and Stroke at the National Institutes of Health FX This research was supported by the Intramural Research Program of the National Institute of Neurologic Disorders and Stroke at the National Institutes of Health. NR 38 TC 44 Z9 45 U1 2 U2 6 PU AMER ASSOC NEUROLOGICAL SURGEONS PI ROLLING MEADOWS PA 5550 MEADOWBROOK DRIVE, ROLLING MEADOWS, IL 60008 USA SN 0022-3085 EI 1933-0693 J9 J NEUROSURG JI J. Neurosurg. PD JUL PY 2012 VL 117 IS 1 BP 109 EP 117 DI 10.3171/2012.3.JNS111649 PG 9 WC Clinical Neurology; Surgery SC Neurosciences & Neurology; Surgery GA 962ZC UT WOS:000305588900021 PM 22503123 ER PT J AU Lucca, JJD Li, YS Simovic, M Pusateri, AE Falabella, M Dubick, MA Tsokos, GC AF Lucca, Jurandir J. Dalle Li, Yansong Simovic, Milomir Pusateri, Anthony E. Falabella, Michael Dubick, Michael A. Tsokos, George C. TI EFFECTS OF C1 INHIBITOR ON TISSUE DAMAGE IN A PORCINE MODEL OF CONTROLLED HEMORRHAGE SO SHOCK LA English DT Article DE Recombinant human C1 inhibitor; hemorrhage; low volume fluid resuscitation; swine; reperfusion injury ID ESTERASE INHIBITOR; COMPLEMENT ACTIVATION; HEREDITARY ANGIOEDEMA; MAJOR TRAUMA; INJURY; RESUSCITATION; C1-INHIBITOR; SHOCK; REPERFUSION; BLOOD AB Activation of the complement system has been associated with tissue injury after hemorrhage and resuscitation in animals. We investigated whether administration of recombinant human C1-esterase inhibitor (rhC1-INH), a regulator of complement and contact activation systems, reduces tissue damage and cytokine release and improves metabolic acidosis in a porcine model of hemorrhagic shock. Male Yorkshire swine were assigned to experimental groups and subjected to controlled, isobaric hemorrhage to a target mean arterial pressure of 35 mmHg. Hypotension was maintained for 20 min followed by a bolus intravenous injection of rhC1-INH or vehicle; animals were then observed for 3 h. Blood chemistry and physiologic parameters were recorded. Lung and small intestine tissue samples were subjected to histopathologic evaluation and immunohistochemistry to determine the extent of injury and deposition of complement proteins. Cytokine levels and quantitative assessment of renal and hepatic function were measured via enzyme-linked immunosorbent assay and chemistry analyzer, respectively. Pharmacokinetics of rhC1-INH revealed dose proportionality for maximum concentration, half-life, and the time span in which the functional C1-INH level was greater than 1 IU/mL. Recombinant human C1-INH significantly reduced renal, intestinal, and lung tissue damage in a dose-dependent manner (100 and 250 IU/kg). In addition, rhC1-INH (250 IU/kg) markedly improved hemorrhage-induced metabolic acidosis and circulating tumor necrosis factor alpha. The tissue-protective effects of rhC1-INH appear to be related to its ability to reduce tissue complement activation and deposition. Recombinant human C1-INH decreased tissue complement activation and deposition in hemorrhaged animals, improved metabolic acidosis, reduced circulating tumor necrosis factor alpha, and attenuated tissue damage in this model. The observed beneficial effects of rhC1-INH treatment on tissue injury 20 min into severe hypotension present an attractive model of low-volume resuscitation, particularly in situations with a restrictive medical logistical footprint. C1 [Lucca, Jurandir J. Dalle; Li, Yansong; Simovic, Milomir; Falabella, Michael] USA, Immunomodulat Trauma Program, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Pusateri, Anthony E.] USA, Combat Casualty Care Res Program, Med Res & Mat Command, Ft Detrick, MD USA. [Tsokos, George C.] Harvard Univ, Sch Med, Dept Med, Beth Israel Deaconess Med Ctr, Boston, MA USA. RP Lucca, JJD (reprint author), USA, Immunomodulat Trauma Program, Inst Surg Res, 3650 Chambers Pass, Ft Sam Houston, TX 78234 USA. EM jurandir.dallelucca@us.army.mil FU US Army Medical Research and Materiel Command FX This study was funded by the US Army Medical Research and Materiel Command. NR 34 TC 5 Z9 5 U1 0 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1073-2322 J9 SHOCK JI Shock PD JUL PY 2012 VL 38 IS 1 BP 82 EP 91 DI 10.1097/SHK.0b013e31825a3522 PG 10 WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System & Cardiology GA 961WV UT WOS:000305501100014 ER PT J AU Ramirez, A Gentlesk, PJ Peele, ME Eckart, RE AF Ramirez, Alexies Gentlesk, Philip J. Peele, Mark E. Eckart, Robert E. TI Management of Central Venous Gradient Using Excimer Laser Lead Extraction of Chronic Indwelling Pacemaker Leads in the Setting of Ipsilateral Arteriovenous Fistula SO VASCULAR AND ENDOVASCULAR SURGERY LA English DT Article DE dialysis; peripheral venoplasty; lead management; pacemakers AB Device therapy is becoming common in those patients with renal insufficiency. Coexisting need for arteriovenous (AV) fistula placement is often contemplated relative to device placement. We describe the excimer laser lead extraction of a malfunctioning chronic atrial pacemaker lead ipsilateral to an AV fistula. C1 [Eckart, Robert E.] Brooke Army Med Ctr, Div Cardiovasc, Cardiac Arrhythmia Serv, San Antonio, TX 78234 USA. RP Eckart, RE (reprint author), Brooke Army Med Ctr, Div Cardiovasc, Cardiac Arrhythmia Serv, San Antonio, TX 78234 USA. EM Robert.Eckart@us.army.mil NR 5 TC 0 Z9 0 U1 1 U2 1 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 1538-5744 J9 VASC ENDOVASC SURG JI Vasc. Endovasc. Surg. PD JUL PY 2012 VL 46 IS 5 BP 414 EP 417 DI 10.1177/1538574412449395 PG 4 WC Surgery; Peripheral Vascular Disease SC Surgery; Cardiovascular System & Cardiology GA 963GR UT WOS:000305608900012 PM 22673493 ER PT J AU Cowan, CM Wink, JS Dezee, KJ AF Cowan, Christopher M. Wink, Jennifer S. Dezee, Kent J. TI Use of the Patient Health Questionnaire-2 to Predict Suicidal Ideations in Patients Taking Varenicline SO AMERICAN JOURNAL ON ADDICTIONS LA English DT Article ID RECEPTOR PARTIAL AGONIST; SUSTAINED-RELEASE BUPROPION; RANDOMIZED CONTROLLED-TRIAL; SMOKING-CESSATION; NICOTINE DEPENDENCE; PSYCHIATRIC-DISORDERS; MAJOR DEPRESSION; GENERAL-PRACTICE; MENTAL-ILLNESS; PRIMARY-CARE AB Varenicline, when taken for smoking cessation, has been associated with suicidal ideations (SI), but the incidence and risk factors for SI are largely unknown. The aim of this paper was to describe the incidence and pretreatment patient factors that are associated with SI when taking varenicline. We conducted a smoking cessation trial of 217 patients at a single center, all of whom took varenicline. Between 6 and 18 months after study completion (when the risk for SI became known), we successfully contacted 72 (response rate 33%) and queried them for SI during varenicline treatment. Of these, 4 (6%) had SI. Self-reported history of depression was not associated with SI (p = 0.11), but depressive symptoms at the time of varenicline initiation as measured by the Patient Health Questionnaire-8 (p = 0.004) and Patient Health Questionnaire-2 (p = 0.007) were associated with SI. The Patient Health Questionnaire-2 (which is only two questions) had a sensitivity of 75% and a specificity of 90% to predict SI. We conclude that current depressive symptoms, not necessarily a history of depression, are associated with SI when taking varenicline for smoking cessation. Providers should consider screening for depressive symptoms before treatment with varenicline. (Am J Addict 2012;21:356-362) C1 [Dezee, Kent J.] Uniformed Serv Univ Hlth Sci, Dept Med, Bethesda, MD 20814 USA. [Wink, Jennifer S.] Natl Jewish Hlth, Dept Med, Denver, CO USA. [Cowan, Christopher M.] 2nd Advise & Assist Brigade, Infantry Div 25, Task Force Brigade Support Battal 225, Schofield Barracks, HI USA. RP Dezee, KJ (reprint author), Uniformed Serv Univ Hlth Sci, Dept Med, 4301 Jones Bridge RD EDP, Bethesda, MD 20814 USA. EM kent.dezee@us.army.mil NR 41 TC 3 Z9 3 U1 0 U2 2 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1055-0496 J9 AM J ADDICTION JI Am. J. Addict. PD JUL-AUG PY 2012 VL 21 IS 4 BP 356 EP 362 DI 10.1111/j.1521-0391.2012.00243.x PG 7 WC Substance Abuse SC Substance Abuse GA 956XH UT WOS:000305122400009 PM 22691015 ER PT J AU Hill, FC Sviatenko, LK Gorb, L Okovytyy, SI Blaustein, GS Leszczynski, J AF Hill, Frances C. Sviatenko, Liudmyla K. Gorb, Leonid Okovytyy, Sergiy I. Blaustein, Gail S. Leszczynski, Jerzy TI DET M06-2X investigation of alkaline hydrolysis of nitroaromatic compounds SO CHEMOSPHERE LA English DT Article DE 2,4,6-Trinitrotoluene; Meisenheimer complex; Janovsky complex; UV-VIS spectra; NMR spectra ID HIGHLY CONTAMINATED SOILS; STRONGLY BASIC-MEDIA; DENSITY FUNCTIONALS; 2,4,6-TRINITROTOLUENE; TRINITROTOLUENE; KINETICS; SODIUM; RATES; TNT; NMR AB The nitroaromatic compounds 2,4,6-trinitrotoluene (TNT), 2,4-dinitrotoluene (DNT) and 2,4-dinitroanisole (DNAN) are potential environmental contaminants and their transformations under a variety of environmental conditions are consequently of great interest. One possible method to safely degrade these nitrocompounds is alkaline hydrolysis. A mechanism of the initial stages of this reaction was investigated computationally. Simulations of UV-VIS and NMR spectra for this mechanism were also produced. The results obtained were compared to available experimental data on the alkaline hydrolysis of TNT and suggest that the formation of Meisenheimer complexes and an anion of TNT are potential first-step intermediates in the reaction path. As the reaction proceeds, computational results indicate that polynegative complexes dominate the degradation pathway, followed by cycles of carbon chain opening and breaking. A second possible pathway was identified that leads to polymeric products through Janovsky complex formation. Results from this study indicate that the order of increasing resistance to alkaline hydrolysis is TNT, DNT and DNAN. (C) 2012 Elsevier Ltd. All rights reserved. C1 [Sviatenko, Liudmyla K.; Okovytyy, Sergiy I.; Leszczynski, Jerzy] Jackson State Univ, Interdisciplinary Ctr Nanotox, Dept Chem & Biochem, Jackson, MS 39217 USA. [Hill, Frances C.; Blaustein, Gail S.; Leszczynski, Jerzy] USA, ERDC, Vicksburg, MS 39180 USA. [Sviatenko, Liudmyla K.] Kirovohrad State Pedag Univ, UA-25006 Kirovohrad, Ukraine. [Gorb, Leonid] Badger Tech Serv LLC, Vicksburg, MS USA. [Okovytyy, Sergiy I.] Dnepropetrovsk Natl Univ, Dept Organ Chem, UA-49010 Dnepropetrovsk, Ukraine. RP Leszczynski, J (reprint author), Jackson State Univ, Interdisciplinary Ctr Nanotox, Dept Chem & Biochem, 325 JR Lynch St,POB 17910, Jackson, MS 39217 USA. EM jerzy@icnanotox.org RI Okovytyy, Sergiy/F-9838-2010 OI Okovytyy, Sergiy/0000-0003-4367-1309 FU USAERDC FX The use of trade, product, or firm names in this report is for descriptive purposes only and does not imply endorsement by the US Government. Results in this study were funded and obtained from research conducted under the Environmental Quality Technology Program of the United States Army Corps of Engineers by the USAERDC. Permission was granted by the Chief of Engineers to publish this information. The findings of this report are not to be construed as an official Department of the Army position unless so designated by other authorized documents. NR 34 TC 12 Z9 12 U1 0 U2 15 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0045-6535 J9 CHEMOSPHERE JI Chemosphere PD JUL PY 2012 VL 88 IS 5 BP 635 EP 643 DI 10.1016/j.chemosphere.2012.03.048 PG 9 WC Environmental Sciences SC Environmental Sciences & Ecology GA 958SV UT WOS:000305261900015 PM 22513338 ER PT J AU Gerges, M AF Gerges, Mark TI Debating Foreign Policy in Eighteenth Century Britain SO HISTORY LA English DT Book Review C1 [Gerges, Mark] USA, Command & Gen Staff Coll, Ft Leavenworth, KS USA. RP Gerges, M (reprint author), USA, Command & Gen Staff Coll, Ft Leavenworth, KS USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0018-2648 EI 1468-229X J9 HISTORY-UK JI History PD JUL PY 2012 VL 97 IS 327 BP 500 EP 501 DI 10.1111/j.1468-229X.2012.00561_17.x PG 2 WC History SC History GA 957TA UT WOS:000305184500022 ER PT J AU Frech, CB Coppola, BP Harris, H Woodbridge, CM AF Frech, Cheryl B. Coppola, Brian P. Harris, Hal Woodbridge, C. M. TI Summer 2012 Book and Media Recommendations SO JOURNAL OF CHEMICAL EDUCATION LA English DT Editorial Material DE General Public; History/Philosophy; Interdisciplinary/Multidisciplinary; Public Understanding/Outreach AB This is a list of recommendations for books and a few Web sites for Journal readers to enjoy in the summer, either in preparation for fall teaching, or for sheer pleasure. Four contributors have assembled an eclectic list in this annual collection. C1 [Frech, Cheryl B.] Univ Cent Oklahoma, Dept Chem, Edmond, OK 73034 USA. [Coppola, Brian P.] Univ Michigan, Dept Chem, Ann Arbor, MI 48109 USA. [Harris, Hal] Univ Missouri, Dept Chem & Biochem, St Louis, MO 63121 USA. [Woodbridge, C. M.] US Mil Acad, Dept Chem & Life Sci, West Point, NY 10996 USA. RP Frech, CB (reprint author), Univ Cent Oklahoma, Dept Chem, Edmond, OK 73034 USA. EM cfrech@uco.edu RI Coppola, Brian P/G-3709-2016 OI Coppola, Brian P/0000-0001-7226-0942 NR 33 TC 0 Z9 0 U1 0 U2 8 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0021-9584 J9 J CHEM EDUC JI J. Chem. Educ. PD JUL PY 2012 VL 89 IS 7 BP 825 EP 831 DI 10.1021/ed300296j PG 7 WC Chemistry, Multidisciplinary; Education, Scientific Disciplines SC Chemistry; Education & Educational Research GA 959JL UT WOS:000305308600002 ER PT J AU Park, SJ Gunn, N Harrison, SA AF Park, Stephen J. Gunn, Nadege Harrison, Stephen A. TI Olanzapine and Benztropine as a Cause of Ischemic Colitis in a 27-year-old Man SO JOURNAL OF CLINICAL GASTROENTEROLOGY LA English DT Article DE ischemic colitis; constipation; olanzapine; benztropine; antipsychotic ID SCHIZOPHRENIA; CONSTIPATION; CLOZAPINE AB Ischemic colitis is a rare adverse effect of antipsychotic medications and is most commonly associated with the phenothiazine class of antipsychotics and atypical antipsychotics such as clozapine and olanzapine. The risk is further increased when antipsychotics are taken in conjunction with anticholinergics. A 27-year-old man with a history of bipolar disorder and depression presented to the emergency department with 6 days of constipation, abdominal pain, nausea, and nonbloody vomiting. He later developed multiple episodes of hematochezia and fever. Within the preceding 2 weeks, his medication regimen of divalproex sodium, aripiprazole, and trihexyphenidyl, had been changed to olanzapine, benztropine, and bupropion. The patient's physical examination showed diffuse abdominal tenderness, guarding, and distension and laboratory tests revealed a leukocytosis. A computed tomographic scan of the abdomen/pelvis showed colitis extending from the splenic flexure to the sigmoid colon, without evidence of perforation. A colonoscopy revealed severe ischemic colitis involving the descending and sigmoid colon, which was confirmed on biopsy. Given the temporal association between the new medications and onset of symptoms, the patient's ischemic colitis was likely caused by olanzapine or the combination of olanzapine and benztropine, likely secondary to their anticholinergic properties. Thus, providers should take a thorough history and counsel patients regarding the risks of constipation when starting antipsychotic medications, particularly those with anticholinergic activity. Despite the fact that ischemic colitis is such a rare adverse effect of antipsychotic medications, it is important to consider because of its potentially fatal outcomes. C1 [Park, Stephen J.] Brooke Army Med Ctr, Dept Med, San Antonio, TX USA. [Gunn, Nadege; Harrison, Stephen A.] Brooke Army Med Ctr, Div Gastroenterol & Hepatol, San Antonio, TX USA. RP Park, SJ (reprint author), Brooke Army Med Ctr, Dept Med, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM sjpark412@gmail.com NR 11 TC 5 Z9 5 U1 1 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0192-0790 J9 J CLIN GASTROENTEROL JI J. Clin. Gastroenterol. PD JUL PY 2012 VL 46 IS 6 BP 515 EP 517 DI 10.1097/MCG.0b013e318231124c PG 3 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 959RW UT WOS:000305331500015 PM 22011585 ER PT J AU Schlussel, AT Holt, DB Crawley, EA Lustik, MB Wade, CE Uyehara, CFT AF Schlussel, Andrew T. Holt, Danielle B. Crawley, Eric A. Lustik, Michael B. Wade, Charles E. Uyehara, Catherine F. T. TI Effects of Hyperglycemia and Continuous Intravenous Insulin on Outcomes of Surgical Patients SO JOURNAL OF SURGICAL RESEARCH LA English DT Article DE hyperglycemia; continuous insulin therapy; surgery ID CRITICALLY-ILL PATIENTS; INTENSIVE-CARE-UNIT; GLUCOSE VARIABILITY; CRITICAL ILLNESS; SITE INFECTIONS; MORTALITY; THERAPY; ASSOCIATION; SURGERY; SEPSIS AB Background. Hyperglycemia in critically ill patients has been associated with increased morbidity and mortality. It is unclear to what degree hyperglycemia should be regulated in a mixed surgical population. Study Design. A retrospective chart review of 210 surgical patients in the intensive care unit (ICU) was performed. All patients were placed on an intravenous insulin protocol targeted to a blood glucose (BG) of 80-140 mg/dL. Outcomes were compared between surgical patients with controlled BG levels (80-140 mg/dL) versus uncontrolled levels (> 140 mg/dL). Results. The mortality rate of this population was 12%, 5% in the controlled BG group compared with 18% in the uncontrolled BG group (P < 0.01). After adjusting for covariates, the mortality rate of the uncontrolled blood glucose group was significantly greater (OR = 4.8, 95% CI 1.4-20; P = 0.02). The overall hypoglycemic rate was < 1%, and was not associated with a higher mortality, P = 0.60. A greater mortality rate was associated with patients who spent a greater time with blood glucose values > 181 mg/dL (OR = 1.3, 95% CI 1.1-1.6; P = 0.01). Conclusions. Increased mortality was associated with surgical patients in the uncontrolled blood glucose group compared with patients who were well controlled with insulin therapy. These results are comparable to previous studies and indicate that surgical patients are a population who may benefit from tighter glycemic control. Further investigations through prospective randomized studies are needed to fully evaluate the effects of hyperglycemia in a diverse surgical population as well as specific surgical subspecialties. (C) 2012 Published by Elsevier Inc. C1 [Lustik, Michael B.; Uyehara, Catherine F. T.] Tripler Army Med Ctr, Dept Clin Invest, Honolulu, HI 96859 USA. [Schlussel, Andrew T.; Holt, Danielle B.] Tripler Army Med Ctr, Dept Gen Surg, Honolulu, HI 96859 USA. [Crawley, Eric A.] Tripler Army Med Ctr, Dept Pulm & Crit Care Med, Honolulu, HI 96859 USA. [Wade, Charles E.] Univ Texas Houston, Sch Med, Dept Surg, Houston, TX USA. [Wade, Charles E.] Univ Texas Houston, Sch Med, Ctr Translat Injury Res, Houston, TX USA. RP Uyehara, CFT (reprint author), Tripler Army Med Ctr, Dept Clin Invest, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM catherine.uyehara@amedd.army.mil FU Technologies for Metabolic Monitoring (TMM)/Julia Weaver Fund; Juvenile Diabetes Research Foundation; Combat Casualty Care Division, United States Army Medical Research and Materiel Command FX This project was supported by The Technologies for Metabolic Monitoring (TMM)/Julia Weaver Fund, a congressionally directed program wjointly managed by the USA MRMC, NIH, NASA, and the Juvenile Diabetes Research Foundation and Combat Casualty Care Division, United States Army Medical Research and Materiel Command. The views expressed in this paper are those of the authors and do not reflect the official policy or position of the Department of the Army, Department of Defense, or the U.S. Government. NR 31 TC 2 Z9 2 U1 0 U2 1 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0022-4804 J9 J SURG RES JI J. Surg. Res. PD JUL PY 2012 VL 176 IS 1 BP 202 EP 209 DI 10.1016/j.jss.2011.07.004 PG 8 WC Surgery SC Surgery GA 958BD UT WOS:000305210100038 PM 21920548 ER PT J AU Black, MD Honda, SAA Uyehara-Lock, JH AF Black, Michael D. Honda, Stacey A. A. Uyehara-Lock, Jane H. TI Two Rare Entities in a Single Patient: The Development of Cutaneous Rosai-Dorfman Disease After Successful Treatment of Langerhans Cell Histiocytosis SO AMERICAN JOURNAL OF CLINICAL PATHOLOGY LA English DT Meeting Abstract C1 [Black, Michael D.; Honda, Stacey A. A.; Uyehara-Lock, Jane H.] Hawaii Pathol Residency Program, Honolulu, HI USA. [Honda, Stacey A. A.; Uyehara-Lock, Jane H.] Kaiser Moanalua Med Ctr, Honolulu, HI USA. [Black, Michael D.; Honda, Stacey A. A.; Uyehara-Lock, Jane H.] John A Burns Sch Med, Honolulu, HI USA. [Uyehara-Lock, Jane H.] Honolulu Asia Aging Study, Honolulu, HI USA. [Uyehara-Lock, Jane H.] Tripler Army Med Ctr, Honolulu, HI 96859 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0002-9173 EI 1943-7722 J9 AM J CLIN PATHOL JI Am. J. Clin. Pathol. PD JUL 1 PY 2012 VL 138 SU 1 MA 84 BP A084 EP A084 PG 1 WC Pathology SC Pathology GA V45XG UT WOS:000209848700080 ER PT J AU Grace, CL Honda, SAA Uyehara-Lock, JH AF Grace, Chelestes Lee Honda, Stacey A. A. Uyehara-Lock, Jane H. TI Can Large Prostatic Glands be Malignant? The Perils of Diagnosing Pseudohyperplastic Variant of Prostatic Adenocarcinoma by Core Needle Biopsy SO AMERICAN JOURNAL OF CLINICAL PATHOLOGY LA English DT Meeting Abstract C1 [Grace, Chelestes Lee; Honda, Stacey A. A.; Uyehara-Lock, Jane H.] Univ Hawaii, Pathol Residency Program, Honolulu, HI 96822 USA. [Grace, Chelestes Lee; Honda, Stacey A. A.; Uyehara-Lock, Jane H.] John A Burns Sch Med, Honolulu, HI USA. [Honda, Stacey A. A.; Uyehara-Lock, Jane H.] Kaiser Moanalua Med Ctr, Honolulu, HI USA. [Uyehara-Lock, Jane H.] Honolulu Asia Aging Study, Honolulu, HI USA. [Uyehara-Lock, Jane H.] Tripler Army Med Ctr, Honolulu, HI 96859 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0002-9173 EI 1943-7722 J9 AM J CLIN PATHOL JI Am. J. Clin. Pathol. PD JUL 1 PY 2012 VL 138 SU 1 MA 105 BP A105 EP A105 PG 1 WC Pathology SC Pathology GA V45XG UT WOS:000209848700101 ER PT J AU Mafnas, CT Honda, SAA Uyehara-Lock, JH AF Mafnas, Chrisy T. Honda, Stacey A. A. Uyehara-Lock, Jane H. TI Do a Positive Occult Fecal Blood Test and a Colonic Mass on Imaging Always Mean Colonic Neoplasm? A Case Report Describing the Rare Entity of Filiform Polyposis in an Asymptomatic Patient Who Underwent Colectomy for Suspected Colonic Neoplasm and Proposal of Strategies to Improve Diagnostic Acumen to Recognize This Rare Entity for the Purpose of Preventing Unnecessary Surgical Procedures Such as Colectomy SO AMERICAN JOURNAL OF CLINICAL PATHOLOGY LA English DT Meeting Abstract C1 [Mafnas, Chrisy T.; Honda, Stacey A. A.; Uyehara-Lock, Jane H.] Hawaii Pathol Residency Program, Honolulu, HI USA. [Honda, Stacey A. A.; Uyehara-Lock, Jane H.] Kaiser Moanalua Med Ctr, Honolulu, HI USA. [Mafnas, Chrisy T.; Honda, Stacey A. A.; Uyehara-Lock, Jane H.] John A Burns Sch Med, Honolulu, HI USA. [Uyehara-Lock, Jane H.] Honolulu Asia Aging Study, Honolulu, HI USA. [Uyehara-Lock, Jane H.] Tripler Army Med Ctr, Honolulu, HI USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0002-9173 EI 1943-7722 J9 AM J CLIN PATHOL JI Am. J. Clin. Pathol. PD JUL 1 PY 2012 VL 138 SU 1 MA 346 BP A346 EP A346 PG 1 WC Pathology SC Pathology GA V45XG UT WOS:000209848700306 ER PT J AU Ritter, FE Bittner, JL Kase, SE Evertsz, R Pedrotti, M Busetta, P AF Ritter, Frank E. Bittner, Jennifer L. Kase, Sue E. Evertsz, Rick Pedrotti, Matteo Busetta, Paolo TI CoJACK: A high-level cognitive architecture with demonstrations of moderators, variability, and implications for situation awareness SO BIOLOGICALLY INSPIRED COGNITIVE ARCHITECTURES LA English DT Article DE Cognitive architecture; BDI; Situation awareness; Behavior moderators; Usability AB We report a high-level architecture, CoJACK, that provides insights on behavior variability, situation awareness, and behavioral moderators. CoJACK combines Beliefs/Desires/Intentions (BDI) agents' high-level knowledge representation and usability with several aspects of low-level cognitive architectures, including processing time predictions, errors, and traceability. CoJACK explores new areas for cognitive architectures, such as variability arising from moderators. It also allows aspects of situation awareness (SA) in a cognitive architecture to be explored. Its behavior and the effects of moderators on behavior are demonstrated in a simple adversarial environment. It provides lessons for other architectures including how to define, measure, and control variability due to individual and temporal aspects of cognition; the importance of SA and knowledge representations necessary to support complex SA; the potential for parameter sweeps and paths as measures of variability; and some of the complexities that will arise when aspects of moderators and SA are added to cognitive architectures. (C) 2012 Elsevier B.V. All rights reserved. C1 [Ritter, Frank E.; Bittner, Jennifer L.] Penn State, Coll IST, University Pk, PA 16802 USA. [Kase, Sue E.] US Army, Res Lab, RDRL CII C, Aberdeen Proving Ground, MD 21005 USA. [Evertsz, Rick; Pedrotti, Matteo; Busetta, Paolo] AOS Grp, Cambridge CB1 1BH, England. RP Ritter, FE (reprint author), Penn State, Coll IST, University Pk, PA 16802 USA. EM frank.ritter@psu.edu; bittnerj@indiana.edu; sue.e.kase.civ@mail.mil; rick.evertsz@aosgrp.com; matteo.pedrotti@aosgrp.com; paolo.busetta@aosgrp.com FU UK MoD's Directorate of Analysis, Experimentation and Simulation corporate research programme [RT/COM/3/006]; ONR [N00014-06-1-0164] FX This work was supported by the UK MoD's Directorate of Analysis, Experimentation and Simulation corporate research programme (Project No. RT/COM/3/006). We thank Susan Chipman, Simon Goss, and Harold Hawkins for useful discussions about modeling, and Ian Greig, Roy McNee, Bharat Patel, and Colin Sheppard for useful discussions about CoJACK. Bit Lewis, along with Damodar Bhandikar and Jeremiah Hiam, helped develop dTank. ONR N00014-06-1-0164 helped support dTank. Comments from Olivier Georgeon, Greg Plumb, participants at the ARL Workshop on Developing and Understanding Computational Models of Macrocognition, and anonymous reviewers of previous versions of this paper as related conference papers, as well as six very responsive, helpful, and kind BICA reviewers helped improve this presentation. NR 54 TC 12 Z9 12 U1 0 U2 2 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 2212-683X EI 2212-6848 J9 BIOL INSPIR COGN ARC JI Biol. Inspired Cogn. Archit. PD JUL PY 2012 VL 1 BP 2 EP 13 DI 10.1016/j.bica.2012.04.004 PG 12 WC Computer Science, Artificial Intelligence; Neurosciences SC Computer Science; Neurosciences & Neurology GA V38RA UT WOS:000209359300002 ER PT J AU Dretsch, MN Thiel, KJ Athy, JR Irvin, CR Sirmon-Fjordbak, B Salvatore, A AF Dretsch, Michael N. Thiel, Kenneth J. Athy, Jeremy R. Irvin, Clinton R. Sirmon-Fjordbak, Bess Salvatore, Anthony TI Mood symptoms contribute to working memory decrement in active-duty soldiers being treated for posttraumatic stress disorder SO BRAIN AND BEHAVIOR LA English DT Article DE Anxiety; depression; digit span; memory; military; neurocognitive AB A significant proportion of military veterans of operations in Afghanistan and Iraq have been diagnosed with posttraumatic stress disorder (PTSD). Growing evidence suggests that neuropsychological deficits are a symptom of PTSD. The current study investigated neurocognitive functioning among soldiers diagnosed with PTSD. Specifically, active-duty soldiers with and without a diagnosis of PTSD were assessed for performance on tests of attention and working memory. In addition, factors such as combat experience, depression, anxiety, PTSD symptom severity, and alcohol consumption were explored as possible mediators of group differences in neurocognitive functioning. Twenty-three active-duty soldiers diagnosed with PTSD were matched with 23 healthy Soldier controls; all were administered the Attention Network Task (ANT), Backward Digit Span (BDS) task, Beck Depression Inventory, Beck Anxiety Inventory, PTSD Checklist-Military Version, Combat Exposure Scale, and Modified Drinking Behavior Questionnaire. Soldiers diagnosed with PTSD performed significantly worse on the working memory task (BDS) than healthy controls, and reported greater levels of PTSD symptoms, combat exposure, depression, and anxiety. However, after controlling for depression and anxiety symptoms, the relationship between PTSD and working memory was no longer present. The results indicate that PTSD is accompanied by deficits in working memory, which appear to be partially attributed to anxiety and depression symptoms. C1 [Dretsch, Michael N.; Thiel, Kenneth J.; Athy, Jeremy R.; Irvin, Clinton R.] US Army Aeromed Res Lab, Ft Rucker, AL 36362 USA. [Sirmon-Fjordbak, Bess; Salvatore, Anthony] Univ Texas El Paso, El Paso, TX 79968 USA. RP Dretsch, MN (reprint author), US Army Aeromed Res Lab, 6901 Farrell Rd,POB 620577, Ft Rucker, AL 36362 USA. EM Michael.dretsch@us.army.mil NR 50 TC 7 Z9 7 U1 1 U2 5 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 2162-3279 J9 BRAIN BEHAV JI Brain Behav. PD JUL PY 2012 VL 2 IS 4 BP 357 EP 364 DI 10.1002/brb3.53 PG 8 WC Behavioral Sciences; Neurosciences SC Behavioral Sciences; Neurosciences & Neurology GA V35US UT WOS:000209174100001 PM 22950039 ER PT J AU Burnfield, JM Shu, Y Buster, TW Taylor, AP McBride, MM Krause, ME AF Burnfield, Judith M. Shu, Yu Buster, Thad W. Taylor, Adam P. McBride, Michaela M. Krause, Megan E. TI Kinematic and electromyographic analyses of normal and device-assisted sit-to-stand transfers SO GAIT & POSTURE LA English DT Article DE Rehabilitation; Safe patient handling; Physical therapy; Arisk factors; Occupational injury ID MUSCULOSKELETAL DISORDERS; PHYSICAL-THERAPISTS; GAIT; DEMANDS AB Mechanical sit-to-stand devices assist patient transfers and help protect against work-related injuries in rehabilitation environments. However, observational differences between patient's movements within devices compared to normal sit-to-stand transfers deter clinician use. This study compared kinematics and muscle demands during sit-to-stand transfers with no device (ND), and device-assisted during which participants exerted no effort (DA-NE) and best effort (DA-BE). Coefficient of multiple correlations (CMCs) compared kinematic profiles during each device-assisted condition to ND. Compared to DA-NE, CMCs were higher during DA-BE at the hip, knee, and ankle. However, DA-BE values were lower than DA-NE at the trunk and pelvis due to the device's mechanical constraints. In general, all joints' final DA-NE postures were more flexed than other conditions. Electromyographic was significantly lower during DA-NE compared to ND for all muscles except lateral hamstring, and during DA-BE compared to ND for gluteus maximus, gastrocnemius, and soleus. Verbal encouragement (DA-BE) significantly increased medial hamstring, vastus lateralis, gastrocnemius, soleus and tibialis anterior activation compared to DA-NE. In conclusion, device-assisted sit-to-stand movements differed from normal sit-to-stand patterns. Verbally encouraging best effort during device-assisted transfers elevated select lower extremity muscle activation and led to greater similarity in hip, knee and ankle movement profiles. However, trunk and pelvis profiles declined. (C) 2012 Elsevier B.V. All rights reserved. C1 [Burnfield, Judith M.; Shu, Yu; Buster, Thad W.; Taylor, Adam P.] Madonna Rehabil Hosp, Inst Rehabil Sci & Engn, Lincoln, NE 68506 USA. [McBride, Michaela M.] USA, Res Lab, Human Res Engn Directorate, Adelphi, MD 20783 USA. [Krause, Megan E.] Univ Michigan, Orthot & Prosthet Ctr, Ann Arbor, MI 48104 USA. RP Burnfield, JM (reprint author), Madonna Rehabil Hosp, Inst Rehabil Sci & Engn, 5401 South St, Lincoln, NE 68506 USA. EM jburnfield@madonna.org FU University of Nebraska-Lincoln FX This work was supported, in part, by Undergraduate Creative Activities and Research Experiences Program and Agricultural Research Division grants from the University of Nebraska-Lincoln. NR 30 TC 11 Z9 12 U1 1 U2 7 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0966-6362 J9 GAIT POSTURE JI Gait Posture PD JUL PY 2012 VL 36 IS 3 BP 516 EP 522 DI 10.1016/j.gaitpost.2012.05.002 PG 7 WC Neurosciences; Orthopedics; Sport Sciences SC Neurosciences & Neurology; Orthopedics; Sport Sciences GA 157OP UT WOS:000319908600036 PM 22727735 ER PT J AU Mudge, CR Haller, WT AF Mudge, Christopher R. Haller, William T. TI Response of target and nontarget floating and emergent aquatic plants to flumioxazin SO JOURNAL OF AQUATIC PLANT MANAGEMENT LA English DT Article DE chemical control; dose response; EC50: Effective Concentration 50; Eichhornia crassipes; Eleocharis interstincta; Landoltia punctata; Panicum hemitomon; Pistia stratiotes; Pontederia cordata; protoporphyrinogen oxidase inhibitor; Sagittaria lancifolia; selectivity AB The effects of subsurface and foliar flumioxazin {2-[7-fluoro-3,4-dihydro-3-oxo-4-(2-propynyl)-2H-1,4-benzoxazin-6-yl]-4,5,6,7-tetrahydro-1H-isoindole-1,3 (2H)w-dione} treatments were evaluated on the floating weeds waterhyacinth (Eichhornia crassipes (Mart.) Solms), water lettuce (Pistia stratiotes L.), and landoltia (Landoltia punctata [G. Mey] D.H. Les and D.J. Crawford) as well as the nontarget emergent species eleocharis (Eleocharis interstincta (Vahl) Roem & J.A. Schult), maidencane (Panicum hemitomon Schult.), pickerelweed (Pontederia cordata L.), and sagittaria (Sagittaria lancifolia L.). All subsurface treatments (>= 100 mu g a.i. L-1) and foliar application rates >143 g a.i. ha(-1) provided complete water lettuce control. Conversely, both flumioxazin application techniques provided <30% control of waterhyacinth. No injury symptoms were exhibited by landoltia treated with foliar flumioxazin applications, and in water, concentrations >= 200 mu g a.i. L-1 were required to provide more than 50% control. Sagittaria was the most sensitive nontarget emergent species to subsurface flumioxazin applications, followed by maidencane, eleocharis, and pickerelweed. Sagittaria dry weight was reduced 100% at herbicide concentrations >= 800 mu g a.i. compared to a 73 to 83% dry weight reduction in eleocharis, maidencane, and pickerelweed. Conversely, all emergent species were highly tolerant to foliar flumioxazin treatments, yielding calculated EC50 values >= 1320 g a.i. ha(-1) for dry weight. Results of this study indicate differential efficacy and selectivity among floating and emergent target and nontarget aquatic plant species when treated with flumioxazin. C1 [Mudge, Christopher R.; Haller, William T.] Univ Florida, Inst Food & Agr Sci, Ctr Aquat & Invas Plants, Gainesville, FL 32611 USA. RP Mudge, CR (reprint author), US Army Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. EM Christopher.R.Mudge@usace.army.mil FU Aquatic Ecosystem Restoration Foundation; Valent USA Corporation; Florida Department of Environmental Protection Bureau of Invasive Plant Management FX The Aquatic Ecosystem Restoration Foundation, Valent USA Corporation, and the Florida Department of Environmental Protection Bureau of Invasive Plant Management provided funding for this research. Product was provided by Valent. Appreciation is extended to Brett Bultemeier, Margaret Glenn, David Mayo, Lyn Gettys, and Tomas Chiconela for technical assistance. Judy Shearer and Ryan Wersal provided reviews of this manuscript. Permission was granted by the Chief of Engineers to publish this information. Citation of trade names does not constitute endorsement or approval of the use of such commercial products. NR 32 TC 4 Z9 4 U1 1 U2 11 PU AQUATIC PLANT MANAGEMENT SOC, INC PI VICKSBURG PA PO BOX 821265, VICKSBURG, MS 39182 USA SN 0146-6623 J9 J AQUAT PLANT MANAGE JI J. Aquat. Plant Manage. PD JUL PY 2012 VL 50 BP 111 EP 116 PG 6 WC Plant Sciences; Marine & Freshwater Biology SC Plant Sciences; Marine & Freshwater Biology GA V33UM UT WOS:000209043700006 ER PT J AU Mudge, CR Heilman, MA Theel, HJ Getsinger, KD AF Mudge, Christopher R. Heilman, M. A. Theel, H. J. Getsinger, K. D. TI Efficacy of subsurface and foliar penoxsulam and fluridone applications on giant salvinia SO JOURNAL OF AQUATIC PLANT MANAGEMENT LA English DT Article DE ALS inhibitor; aquatic fern; chemical control; diquat; exotic weed; foliar herbicide application; glyphosate; PDS inhibitor; Salvinia molesta; subsurface herbicide application AB Giant salvinia (Salvinia molesta Mitchell) continues to be problematic and spread throughout the southern portion of the United States. Traditional management of this invasive weed has been application of the foliar herbicides diquat, glyphosate, and combinations of the two. Unfortunately, thick surface mats that limit contact with foliar sprays and fast recovery potential have resulted in mixed efficacy. Three experiments were conducted to determine the efficacy of subsurface and foliar penoxsulam and subsurface fluridone applications on giant salvinia. These studies were conducted to determine concentration exposure time (CET) relationships, determine if repeat applications can be as effective as single static applications of each respective herbicide, and if subsurface or foliar applications will control mature giant salvinia compared to standard foliar treatments used operationally. In the CET experiment, both herbicides were more effective at growth regulating or controlling giant salvinia when exposed >= 8 wk, regardless of concentration. All penoxsulam concentrations evaluated (5 to 40 mu g a.i. L-1) resulted in initial growth regulation of giant salvinia as early as 1 week after treatment, followed by either new healthy growth (1 to 4 wk exposure) or tissue destruction (>4 wk exposure). Static penoxsulam treatments (10 and 20 mu g L-1) decreased plant dry weight 88 to 100% compared to the nontreated control. Penoxsulam foliar (24 h exposure) plus fluridone subsurface, penoxsulam foliar (24 h exposure), and penoxsulam foliar (static) reduced plant biomass to below pretreatment level in the third experiment. All herbicide treatments, except fluridone subsurface (20 mu g a.i. L-1 with 8 wk exposure), were as effective or provided greater giant salvinia control than the standard operational mix of glyphosate plus diquat plus two surfactants. These data confirm that penoxsulam and fluridone can be used operationally to control giant salvinia. C1 [Mudge, Christopher R.; Heilman, M. A.; Theel, H. J.] US Army Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. [Heilman, M. A.] SePRO Corp, Carmel, IN 46032 USA. RP Mudge, CR (reprint author), US Army Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. EM Christopher.R.Mudge@usace.army.mil FU SePRO Corporation/Aquatic Ecosystem Restoration Foundation; US Army Aquatic Plant Control Research Program FX This research was supported by SePRO Corporation/Aquatic Ecosystem Restoration Foundation and the US Army Aquatic Plant Control Research Program. Appreciation is extended to L. Nelson, C. Grodowitz, J. Namanny, M. Robertson, J. Smith, K. DeRossette, M. Sternberg, and A. Poovey for technical assistance throughout the research. D. Sanders (LSU AgCenter) and A. Perret (Louisiana Department of Wildlife and Fisheries) kindly provided recommendations on giant salvinia control in Louisiana. M. Netherland and L. Glomski kindly provided reviews of this manuscript. Permission was granted by the Chief of Engineers to publish this information. Citation of trade names does not constitute endorsement or approval of the use of such commercial products. NR 33 TC 3 Z9 3 U1 0 U2 4 PU AQUATIC PLANT MANAGEMENT SOC, INC PI VICKSBURG PA PO BOX 821265, VICKSBURG, MS 39182 USA SN 0146-6623 J9 J AQUAT PLANT MANAGE JI J. Aquat. Plant Manage. PD JUL PY 2012 VL 50 BP 116 EP 124 PG 9 WC Plant Sciences; Marine & Freshwater Biology SC Plant Sciences; Marine & Freshwater Biology GA V33UM UT WOS:000209043700007 ER PT J AU Theel, HJ Nelson, LS Mudge, CR AF Theel, Heather J. Nelson, Linda S. Mudge, Christopher R. TI Growth regulating hydrilla and subsequent effects on habitat complexity SO JOURNAL OF AQUATIC PLANT MANAGEMENT LA English DT Article DE bensulfuron-methyl; flurprimidol; habitat complexity; Hydrilla verticillata; imazamox; plant growth regulation AB Plant growth regulators (PGRs), such as flurprimidol ([alpha-(1-methylethyl)-alpha-[4-(trifluoromethoxy) phenyl]-5 pyrimidinemethanol]), and herbicides with growth regulating properties, such as imazamox (2-[4.5-dihydro-4-methyl-4-(1-methylethyl)-5-oxo-1H-imidazol-2-yl]-5-(methoxymethyl)-3-pyridinecarboxylic acid-3-pyridinecarboxylic acid), and bensulfuron-methyl (methyl 2-[[[[[(4,6-dimethoxy-2-pyrimidinyl)amino]carbonyl]amino]sulfonyl]methyl]benzoate) have been reported to control or suppress hydrilla (Hydrilla verticillata [L.f.] Royle) growth while maintaining the vegetative structure important for fish and invertebrates. This change in vegetative structure created by the use of PGRs and herbicides with growth-regulating properties has not been quantified in terms of habitat complexity. Therefore, we investigated the effects of a static exposure of flurprimidol (active ingredient 150 and 300 mu g ai L-1) and bensulfuronmethyl (5 mu g ai L-1), as well as a 14-day exposure of imazamox (50 and 100 mu g ai L-1) on hydrilla growth and aquatic habitat complexity. Results at 12 weeks after treatment indicate that flurprimidol, imazamox, and bensulfuron-methyl reduced hydrilla shoot length 46 to 69%. Imazamox (50 and 100 mu g ai L-1) and bensulfuron-methyl (5 mu g ai L-1) reduced hydrilla shoot biomass by an average of 68%. Habitat complexity was reduced in all treatments by an average of 93%. These results indicate that plant growth regulation may be a viable tool to decrease hydrilla's "weediness" while maintaining habitat complexity beneficial for fish and other aquatic fauna. C1 [Theel, Heather J.; Nelson, Linda S.; Mudge, Christopher R.] US Army Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA. RP Theel, HJ (reprint author), US Army Engineer Res & Dev Ctr, Environm Lab, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM Heather.J.Theel@usace.army.mil FU Florida Fish and Wildlife Conservation Commission's Invasive Plant Management Section FX The authors thank Mike Netherland and Kurt Getsinger for critical review of an earlier version of this manuscript. Permission was granted by the Chief of Engineers to publish this information. Citation of trade or generic chemical names does not constitute an official endorsement or approval of such commercial products. This research was funded by the Florida Fish and Wildlife Conservation Commission's Invasive Plant Management Section, and conducted under the US Army Corps of Engineers Aquatic Plant Control Research Program, Environmental Laboratory, US Army Research and Development Center. Technical assistance was provided by J. Namanny and C. Grodowitz. NR 34 TC 0 Z9 0 U1 0 U2 2 PU AQUATIC PLANT MANAGEMENT SOC, INC PI VICKSBURG PA PO BOX 821265, VICKSBURG, MS 39182 USA SN 0146-6623 J9 J AQUAT PLANT MANAGE JI J. Aquat. Plant Manage. PD JUL PY 2012 VL 50 BP 129 EP 135 PG 7 WC Plant Sciences; Marine & Freshwater Biology SC Plant Sciences; Marine & Freshwater Biology GA V33UM UT WOS:000209043700009 ER PT J AU Berger, ST Netherland, MD Macdonald, GE AF Berger, Sarah T. Netherland, Michael D. Macdonald, Gregory E. TI Evaluating fluridone sensitivity of multiple hybrid and Eurasian watermilfoil accessions under mesocosm conditions SO JOURNAL OF AQUATIC PLANT MANAGEMENT LA English DT Article DE 1-methyl-3-phenyl-5-3-(trifluoromethyl)phenyl-41H-pyridinone; aquatic plant management; herbicide tolerance; hybridity; resistance AB The recent confirmation of widespread watemiilfoil hybridity throughout the northern tier states has led some aquatic plant managers to suggest these invasive hybrids have increased tolerance to various management efforts, including the use of fluridone (1-methyl-3-phenyl-5-[3-(trifluoromethyl) phenyl]-4(1H)-pyridinone) for whole-lake management. In this study we evaluated a hybrid watermilfoil (Myriophyllum spicatum x M. sibiricum) population from Townline Lake in Michigan that has been putatively identified as fluridone tolerant. We compared this plant to three separate populations of Eurasian watermilfoil (M. spicatum L.) and two distinct populations of hybrid watermilfoil. All watermilfoil populations were grown together in mesocosnas and exposed to static fluridone treatments ranging from 3 to 36 mu g L-1. Fluorescence yield was measured on apical shoots over time and plant biomass was harvested to compare herbicide response between watermilfoil populations. All Eurasian watermilfoil and hybrid watermilfoil populations, except Townline, responded similarly to fluridone. In contrast, the Townline hybrid showed increased fluorescence yield and biomass when compared to other watermilfoil populations at fluridone concentrations between 3 and 12 mu g L-1, confirming an increased tolerance to low concentrations of fluridone. The current mechanism for the increased fluridone tolerance by this hybrid population is not yet understood. These results also illustrate that not all hybrids show an increased tolerance to fluridone. Because many states allow only 5 to 15 mu g L-1 of fluridone for control of watermilfoil, the elevated tolerance of the Townline population at these fluridone rates has implications for regulation of aquatic herbicide applications. Documentation of a fluridone-tolerant population suggests that further sampling and testing is warranted to determine if other fluridone-tolerant watermilfoil populations exist in different waterbodies, especially those near Townline Lake. C1 [Berger, Sarah T.; Macdonald, Gregory E.] Univ Florida, Dept Agron, Gainesville, FL 32611 USA. [Netherland, Michael D.] US Army ERDC, Gainesville, FL 32653 USA. RP Berger, ST (reprint author), Univ Florida, Dept Agron, Gainesville, FL 32611 USA. EM sberger@ufl.edu FU Michigan Department of Environmental Quality grant; US Army Aquatic Plant Control Research Program FX Thanks to Caleb James, Heather Hayward, Patricia Phillips, and Amanda Mercer for help with the molecular identifications of watermilfoils. In addition, comments and suggestions from three anonymous reviewers improved the initial draft of this manuscript. This study was funded in part by a Michigan Department of Environmental Quality grant awarded to RAT. Parts of this research were funded under the US Army Aquatic Plant Control Research Program and permission to publish this information was granted by the Chief of Engineers. NR 24 TC 6 Z9 6 U1 1 U2 4 PU AQUATIC PLANT MANAGEMENT SOC, INC PI VICKSBURG PA PO BOX 821265, VICKSBURG, MS 39182 USA SN 0146-6623 J9 J AQUAT PLANT MANAGE JI J. Aquat. Plant Manage. PD JUL PY 2012 VL 50 BP 135 EP 146 PG 12 WC Plant Sciences; Marine & Freshwater Biology SC Plant Sciences; Marine & Freshwater Biology GA V33UM UT WOS:000209043700010 ER PT J AU Williamson, ML Ryan, EJ Fickes, EJ Kim, CH Gunstad, J Kamimori, GH Glickman, EL AF Williamson, Megan L. Ryan, Edward J. Fickes, Emily J. Kim, Chul H. Gunstad, John Kamimori, Gary H. Glickman, Ellen L. TI Caffeine, Exercise, And Selective Attention SO JOURNAL OF GENERAL INTERNAL MEDICINE LA English DT Meeting Abstract C1 [Williamson, Megan L.; Ryan, Edward J.; Fickes, Emily J.; Kim, Chul H.; Gunstad, John; Glickman, Ellen L.] Kent State Univ, Kent, OH 44242 USA. [Kamimori, Gary H.] Walter Reed Army Inst Res, Silver Spring, MD USA. EM mwilli93@kent.edu NR 0 TC 0 Z9 0 U1 0 U2 2 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0884-8734 EI 1525-1497 J9 J GEN INTERN MED JI J. Gen. Intern. Med. PD JUL PY 2012 VL 27 SU 2 MA 1301 BP 256 EP 256 PG 1 WC Health Care Sciences & Services; Medicine, General & Internal SC Health Care Sciences & Services; General & Internal Medicine GA V35IG UT WOS:000209142901058 ER PT J AU Shultz, SJ Wideman, L Montgomery, MM Beasley, KN Nindl, BC AF Shultz, Sandra J. Wideman, Laurie Montgomery, Melissa M. Beasley, Kathleen N. Nindl, Bradley C. TI Changes in Serum Collagen Markers and IGF-I and Knee Joint Laxity Across the Menstrual Cycle SO JOURNAL OF GENERAL INTERNAL MEDICINE LA English DT Meeting Abstract C1 [Shultz, Sandra J.; Wideman, Laurie; Montgomery, Melissa M.] UNC Greensboro, Greensboro, NC USA. [Beasley, Kathleen N.; Nindl, Bradley C.] US Army Res Inst Environm Med, Natick, MA USA. EM sjshultz@uncg.edu NR 0 TC 0 Z9 0 U1 1 U2 1 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0884-8734 EI 1525-1497 J9 J GEN INTERN MED JI J. Gen. Intern. Med. PD JUL PY 2012 VL 27 SU 2 MA 1317 BP 261 EP 261 PG 1 WC Health Care Sciences & Services; Medicine, General & Internal SC Health Care Sciences & Services; General & Internal Medicine GA V35IG UT WOS:000209142901074 ER PT J AU Crowder, TA AF Crowder, Todd A. TI Aerobic Capacity Influence on Load Carriage Performance and High Intensity Activity Recovery SO JOURNAL OF GENERAL INTERNAL MEDICINE LA English DT Meeting Abstract C1 [Crowder, Todd A.] US Mil Acad, West Point, NY 10996 USA. EM todd.crowder@usma.edu NR 0 TC 0 Z9 0 U1 0 U2 1 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0884-8734 EI 1525-1497 J9 J GEN INTERN MED JI J. Gen. Intern. Med. PD JUL PY 2012 VL 27 SU 2 MA 1608 BP 366 EP 366 PG 1 WC Health Care Sciences & Services; Medicine, General & Internal SC Health Care Sciences & Services; General & Internal Medicine GA V35IG UT WOS:000209142901364 ER PT J AU Graham, BS Knapik, JJ Colliver, K Grier, T Steelman, R Jones, B AF Graham, Bria S. Knapik, Joseph J. Colliver, Keith Grier, Tyson Steelman, Ryan Jones, Bruce TI Comparison of Injury Incidence in Two Different Military Parachuting Systems During United States Army Airborne Training SO JOURNAL OF GENERAL INTERNAL MEDICINE LA English DT Meeting Abstract C1 [Graham, Bria S.; Knapik, Joseph J.; Grier, Tyson; Steelman, Ryan; Jones, Bruce] US Army Publ Hlth Command, Aberdeen Proving Ground, MD USA. [Colliver, Keith] Engility Corp, Ft Belvior, VA USA. EM bria.graham@us.army.mil NR 0 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0884-8734 EI 1525-1497 J9 J GEN INTERN MED JI J. Gen. Intern. Med. PD JUL PY 2012 VL 27 SU 2 MA 1612 BP 367 EP 368 PG 3 WC Health Care Sciences & Services; Medicine, General & Internal SC Health Care Sciences & Services; General & Internal Medicine GA V35IG UT WOS:000209142901368 ER PT J AU Grier, T Swedler, D Jones, BH AF Grier, Tyson Swedler, David Jones, Bruce H. TI Effect of Body Mass Index and Aerobic Fitness on Injury Risks in US Army Trainees SO JOURNAL OF GENERAL INTERNAL MEDICINE LA English DT Meeting Abstract C1 [Grier, Tyson; Swedler, David; Jones, Bruce H.] US Army Publ Hlth Command, Aberdeen Proving Ground, MD USA. EM Tyson.Grier@us.army.mil NR 0 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0884-8734 EI 1525-1497 J9 J GEN INTERN MED JI J. Gen. Intern. Med. PD JUL PY 2012 VL 27 SU 2 MA 1610 BP 367 EP 367 PG 1 WC Health Care Sciences & Services; Medicine, General & Internal SC Health Care Sciences & Services; General & Internal Medicine GA V35IG UT WOS:000209142901366 ER PT J AU Loringer, KA Bedno, SA Kao, TC Hauret, K AF Loringer, Kelly A. Bedno, Sheryl A. Kao, Tzu-Cheg Hauret, Keith TI Incidence of Sports Injuries in the Military: 2008 Survey of Active Duty Military Members SO JOURNAL OF GENERAL INTERNAL MEDICINE LA English DT Meeting Abstract C1 [Loringer, Kelly A.; Hauret, Keith] US Army Publ Hlth Command, Aberdeen Proving Ground, MD USA. [Bedno, Sheryl A.] Dwight D Eisenhower Army Med Ctr, Ft Gordon, GA USA. [Kao, Tzu-Cheg] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. EM kelly.loringer@us.army.mil NR 0 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0884-8734 EI 1525-1497 J9 J GEN INTERN MED JI J. Gen. Intern. Med. PD JUL PY 2012 VL 27 SU 2 MA 1611 BP 367 EP 367 PG 1 WC Health Care Sciences & Services; Medicine, General & Internal SC Health Care Sciences & Services; General & Internal Medicine GA V35IG UT WOS:000209142901367 ER PT J AU Roy, TC Seay, J AF Roy, Tanja C. Seay, Joseph TI Low Back Pain Prevalence and Mechanisms of Injury in an Infantry Brigade Serving in Afghanistan SO JOURNAL OF GENERAL INTERNAL MEDICINE LA English DT Meeting Abstract C1 [Roy, Tanja C.; Seay, Joseph] US Army Res Inst Environm Med, Natick, MA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0884-8734 EI 1525-1497 J9 J GEN INTERN MED JI J. Gen. Intern. Med. PD JUL PY 2012 VL 27 SU 2 MA 1613 BP 368 EP 368 PG 1 WC Health Care Sciences & Services; Medicine, General & Internal SC Health Care Sciences & Services; General & Internal Medicine GA V35IG UT WOS:000209142901369 ER PT J AU Hendrickson, NR Sharp, MA Staab, JS McClung, HL Michniak-Kohn, BB Adam, GE Nindl, BC AF Hendrickson, Nathan R. Sharp, Marilyn A. Staab, Jeffery S. McClung, Holly L. Michniak-Kohn, Bozena B. Adam, Gina E. Nindl, Bradley C. TI Quercetin's Influence On Muscle Soreness, Markers Of Inflammation, And Muscle Damage SO JOURNAL OF GENERAL INTERNAL MEDICINE LA English DT Meeting Abstract C1 [Hendrickson, Nathan R.; Sharp, Marilyn A.; Staab, Jeffery S.; McClung, Holly L.; Adam, Gina E.; Nindl, Bradley C.] US Army Res Inst Environm Med, Natick, MA USA. [Michniak-Kohn, Bozena B.] Rutgers State Univ, Piscataway, NJ USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0884-8734 EI 1525-1497 J9 J GEN INTERN MED JI J. Gen. Intern. Med. PD JUL PY 2012 VL 27 SU 2 MA 1779 BP 428 EP 429 PG 3 WC Health Care Sciences & Services; Medicine, General & Internal SC Health Care Sciences & Services; General & Internal Medicine GA V35IG UT WOS:000209142901534 ER PT J AU Sharp, MA Hendrickson, NR Staab, JS McClung, HL Michniak-Kohn, B Catrambone, DE Adam, GE Nindl, BC AF Sharp, Marilyn A. Hendrickson, Nathan R. Staab, Jeffery S. McClung, Holly L. Michniak-Kohn, Bozena Catrambone, Daniel E. Adam, Gina E. Nindl, Bradley C. TI Quercetin Did Not Influence Exercise Performance or Plasma Metabolic Markers in Soldiers SO JOURNAL OF GENERAL INTERNAL MEDICINE LA English DT Meeting Abstract C1 [Sharp, Marilyn A.; Hendrickson, Nathan R.; Staab, Jeffery S.; McClung, Holly L.; Catrambone, Daniel E.; Adam, Gina E.; Nindl, Bradley C.] US Army Res Inst Environm Med, Natick, MA USA. [Michniak-Kohn, Bozena] Rutgers State Univ, New Brunswick, NJ 08903 USA. EM marilyn.sharp@us.army.mil NR 0 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0884-8734 EI 1525-1497 J9 J GEN INTERN MED JI J. Gen. Intern. Med. PD JUL PY 2012 VL 27 SU 2 MA 1780 BP 429 EP 429 PG 1 WC Health Care Sciences & Services; Medicine, General & Internal SC Health Care Sciences & Services; General & Internal Medicine GA V35IG UT WOS:000209142901535 ER PT J AU Sauer, S Ely, B Kenefick, R Seay, J Cheuvront, S AF Sauer, Shane Ely, Brett Kenefick, Robert Seay, Joseph Cheuvront, Samuel TI Effects Of Dehydration On Measures Of Quiet Standing Balance SO JOURNAL OF GENERAL INTERNAL MEDICINE LA English DT Meeting Abstract C1 [Sauer, Shane; Ely, Brett; Kenefick, Robert; Seay, Joseph; Cheuvront, Samuel] US Army Res Inst Environm Med, Natick, MA USA. EM shane.sauer@us.army.mil NR 0 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0884-8734 EI 1525-1497 J9 J GEN INTERN MED JI J. Gen. Intern. Med. PD JUL PY 2012 VL 27 SU 2 MA 2048 BP 525 EP 525 PG 1 WC Health Care Sciences & Services; Medicine, General & Internal SC Health Care Sciences & Services; General & Internal Medicine GA V35IG UT WOS:000209142902160 ER PT J AU Fickes, EJ Ryan, EJ Kim, CH Williamson, ML Gunstad, J Barkley, JE Kamimori, GH Glickman, EL AF Fickes, Emily J. Ryan, Edward J. Kim, Chul-Ho Williamson, Megan L. Gunstad, John Barkley, Jacob E. Kamimori, Gary H. Glickman, Ellen L. TI Perceptual Responses to Cycling Following Caffeine Administration in Chewing Gum SO JOURNAL OF GENERAL INTERNAL MEDICINE LA English DT Meeting Abstract C1 [Fickes, Emily J.; Ryan, Edward J.; Kim, Chul-Ho; Williamson, Megan L.; Gunstad, John; Barkley, Jacob E.; Glickman, Ellen L.] Kent State Univ, Kent, OH 44242 USA. [Kamimori, Gary H.] Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0884-8734 EI 1525-1497 J9 J GEN INTERN MED JI J. Gen. Intern. Med. PD JUL PY 2012 VL 27 SU 2 MA 2073 BP 534 EP 535 PG 3 WC Health Care Sciences & Services; Medicine, General & Internal SC Health Care Sciences & Services; General & Internal Medicine GA V35IG UT WOS:000209142902185 ER PT J AU Gregory, RW Bond, BM AF Gregory, Robert W. Bond, Bryan M. TI Biomechanics of Movement-Related Effort: Effects of Task SO JOURNAL OF GENERAL INTERNAL MEDICINE LA English DT Meeting Abstract C1 [Gregory, Robert W.] US Mil Acad, West Point, NY 10996 USA. [Bond, Bryan M.] Univ Kansas, Lawrence, KS 66045 USA. EM robert.gregory@usma.edu NR 0 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0884-8734 EI 1525-1497 J9 J GEN INTERN MED JI J. Gen. Intern. Med. PD JUL PY 2012 VL 27 SU 2 MA 2292 BP 612 EP 613 PG 3 WC Health Care Sciences & Services; Medicine, General & Internal SC Health Care Sciences & Services; General & Internal Medicine GA V35IG UT WOS:000209142902404 ER PT J AU Linberg, AA Sweet, AF Andrews, AM AF Linberg, Alison A. Sweet, Allison F. Andrews, Anne M. TI Oxygen Consumption Of Individuals With And Without Lower Extremity Amputations During Self-selected Pace Running SO JOURNAL OF GENERAL INTERNAL MEDICINE LA English DT Meeting Abstract C1 [Linberg, Alison A.; Andrews, Anne M.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [Sweet, Allison F.] Gen Leonard Wood Army Community Hosptial, Ft Leonard Wood, MO USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0884-8734 EI 1525-1497 J9 J GEN INTERN MED JI J. Gen. Intern. Med. PD JUL PY 2012 VL 27 SU 2 MA 2486 BP 678 EP 678 PG 1 WC Health Care Sciences & Services; Medicine, General & Internal SC Health Care Sciences & Services; General & Internal Medicine GA V35IG UT WOS:000209142902587 ER PT J AU Seay, JF Frykman, PN Gutekunst, DJ AF Seay, Joseph F. Frykman, Peter N. Gutekunst, David J. TI Constrained Cadence Marching Leads to Higher Peak Tibial Accelerations SO JOURNAL OF GENERAL INTERNAL MEDICINE LA English DT Meeting Abstract C1 [Seay, Joseph F.; Frykman, Peter N.; Gutekunst, David J.] US Army, Environm Med Res Inst, Natick, MA 01760 USA. EM joseph.seay@us.army.mil NR 0 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0884-8734 EI 1525-1497 J9 J GEN INTERN MED JI J. Gen. Intern. Med. PD JUL PY 2012 VL 27 SU 2 MA 2524 BP 691 EP 692 PG 3 WC Health Care Sciences & Services; Medicine, General & Internal SC Health Care Sciences & Services; General & Internal Medicine GA V35IG UT WOS:000209142902625 ER PT J AU Jackson, JL O'Malley, PG Hanson, J AF Jackson, Jeffrey L. O'Malley, Patrick G. Hanson, Janice TI MODEL OF ADHERENCE TO BLOOD PRESSURE MEDICATIONS SO JOURNAL OF GENERAL INTERNAL MEDICINE LA English DT Meeting Abstract C1 [Jackson, Jeffrey L.] Zablocki VAMC, Milwaukee, WI USA. [O'Malley, Patrick G.; Hanson, Janice] Walter Reed Army Med Ctr, Bethesda, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0884-8734 EI 1525-1497 J9 J GEN INTERN MED JI J. Gen. Intern. Med. PD JUL PY 2012 VL 27 SU 2 BP S249 EP S249 PG 1 WC Health Care Sciences & Services; Medicine, General & Internal SC Health Care Sciences & Services; General & Internal Medicine GA V35IG UT WOS:000209142900353 ER PT J AU Lawrence, V Noel, PH Yoder, LH Cornell, JE Johnson, AE Hsu, JR Wolf, SE AF Lawrence, Valerie Noel, Polly H. Yoder, Linda H. Cornell, John E. Johnson, Anthony E. Hsu, Joseph R. Wolf, Steven E. TI MENTAL HEALTH STATUS AND PHYSICAL FUNCTION OF COMBAT-INJURED MILITARY PERSONNEL AT HOSPITAL DISCHARGE SO JOURNAL OF GENERAL INTERNAL MEDICINE LA English DT Meeting Abstract C1 [Lawrence, Valerie; Noel, Polly H.; Cornell, John E.] South Texas Vet Hlth Care Syst, San Antonio, TX USA. [Lawrence, Valerie; Noel, Polly H.; Cornell, John E.] Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA. [Yoder, Linda H.] Univ Texas Austin, Austin, TX 78712 USA. [Yoder, Linda H.; Hsu, Joseph R.] US Army Inst Surg Res, Ft Sam Houston, TX USA. [Johnson, Anthony E.; Hsu, Joseph R.] San Antonio Mil Med Ctr, Ft Sam Houston, TX USA. [Wolf, Steven E.] Univ Texas SW Med Ctr Dallas, Dallas, TX 75390 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0884-8734 EI 1525-1497 J9 J GEN INTERN MED JI J. Gen. Intern. Med. PD JUL PY 2012 VL 27 SU 2 BP S246 EP S247 PG 2 WC Health Care Sciences & Services; Medicine, General & Internal SC Health Care Sciences & Services; General & Internal Medicine GA V35IG UT WOS:000209142900347 ER PT J AU Wright, PJ Kim, PY Wilk, JE Thomas, JL AF Wright, Paul J. Kim, Paul Y. Wilk, Joshua E. Thomas, Jeffrey L. TI The Effects of Mental Health Symptoms and Organizational Climate on Intent to Leave the Military Among Combat Veterans SO MILITARY MEDICINE LA English DT Article AB Frequent deployments to Iraq and Afghanistan have placed a strain on military retention. There is a need to determine contributing factors predicting intent to leave the military. The purpose of this study was to determine to what extent soldiers' mental health symptoms and perceptions of organizational climate are associated with intent to leave the military. Participants (n = 892) were soldiers of one infantry brigade combat team stationed in the United States, anonymously surveyed approximately 6 months after returning from a combat deployment to Iraq. The survey assessed overall deployment experiences, mental health symptoms, and perceptions of organizational climate. Results showed that soldiers reporting higher perceived organizational support were significantly less likely to report intent to leave and those screening positive for anxiety were significantly more likely to report intent to leave than those not screening positive. Implications of these results for Army clinicians and career counselors are discussed. C1 [Wright, Paul J.; Kim, Paul Y.; Wilk, Joshua E.; Thomas, Jeffrey L.] Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. RP Wright, PJ (reprint author), Walter Reed Army Inst Res, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. RI Dopko, Rae/J-7437-2015 NR 36 TC 2 Z9 2 U1 0 U2 3 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD JUL PY 2012 VL 177 IS 7 BP 773 EP 779 PG 7 WC Medicine, General & Internal SC General & Internal Medicine GA V33NZ UT WOS:000209026800003 PM 22808882 ER PT J AU Deering, S Sawyer, T Mikita, J Maurer, D Roth, BJ AF Deering, Shad Sawyer, Taylor Mikita, Jeffrey Maurer, Douglas Roth, Bernard J. CA Central Simulation Committee TI The Central Simulation Committee (CSC): A Model for Centralization and Standardization of Simulation-Based Medical Education in the US Army Healthcare System SO MILITARY MEDICINE LA English DT Article AB In this report, we describe the organizational framework, operations and current status of the Central Simulation Committee (CSC). The CSC was established in 2007 with the goals of standardizing simulation-based training in Army graduate medical education programs, assisting in redeployment training of physicians returning from war, and improving patient safety within the Army Medical Department. Presently, the CSC oversees 10 Simulation Centers, controls over 21,000 sq ft of simulation center space, and provides specialty-specific training in 14 medical specialties. In the past 2 years, CSC Simulation Centers have trained over 50,000 Army medical students, residents, physician assistants, nurses, Soldiers and DoD civilian medical personnel. We hope this report provides simulation educators within the military, and our civilian simulation colleagues, with insight into the workings of our organization and provides an example of centralized support and oversight of simulation-based medical education. C1 [Deering, Shad] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [Sawyer, Taylor] Tripler Army Med Ctr, Honolulu, HI 96859 USA. [Mikita, Jeffrey] Walter Reed Natl Mil Med Ctr, Bethesda, MD 20889 USA. [Maurer, Douglas] Carl R Darnall Army Med Ctr, Fort Hood, TX 76544 USA. [Roth, Bernard J.] Madigan Army Med Ctr, Tacoma, WA 98431 USA. RP Deering, S (reprint author), Uniformed Serv Univ Hlth Sci, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA. NR 11 TC 2 Z9 3 U1 1 U2 5 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD JUL PY 2012 VL 177 IS 7 BP 829 EP 835 PG 7 WC Medicine, General & Internal SC General & Internal Medicine GA V33NZ UT WOS:000209026800011 PM 22808890 ER PT J AU Hill, OT Kay, AB Wahi, MM McKinnon, CJ Bulathsinhala, L Haley, TF AF Hill, Owen T. Kay, Ashley B. Wahi, Monika M. McKinnon, Craig J. Bulathsinhala, Lakmini Haley, Timothy F. TI Rates of Knee Injury in the US Active Duty Army, 2000-2005 SO MILITARY MEDICINE LA English DT Article AB We sought to summarize knee injuries (KI) in the U.S. Active Duty Army (ADA) in terms of absolute numbers, examine current rate trends, and identify ADA who were at increased risk for experiencing a KI. We used the Total Army Injury and Health Outcomes Database (TAIHOD) to compute unadjusted and adjusted rates of KI, categorized by the Bare 11 Matrix, within the ADA for the years 2000-2005. During this period, 21 to 25 per 1,000 ADA suffered from KI. The highest yearly rates were observed for knee dislocation and sprains/strains (31 per 1,000 ADA). In ADA with a history of a KI (within 2 years), rates increased nearly tenfold. Elevated KI rates were also seen in ADA with prior upper or lower leg injuries, those >30 years of age, and those with a category IV Armed Forces Qualification Test score (lowest admissible in Army). ADA KI rates remained fairly stable throughout the study period. Relative to other ADA Soldiers, those with prior knee, upper leg, or lower leg injuries are at increased risk for subsequent KI. C1 [Hill, Owen T.; Wahi, Monika M.; McKinnon, Craig J.; Bulathsinhala, Lakmini; Haley, Timothy F.] US Army, Environm Med Res Inst, Natick, MA 01760 USA. [Kay, Ashley B.] Social Sect Dev Strategies Inc, Boston, MA 02118 USA. RP Hill, OT (reprint author), US Army, Environm Med Res Inst, 15 Kansas St,Bldg 42, Natick, MA 01760 USA. FU Military Operational Medicine Research Program [8840] FX This study was made possible by internal funding from the Military Operational Medicine Research Program, Proposal No. 8840. This research was supported in part by an appointment to the Postgraduate Research Participation Program at the U.S. Army Research Institute of Environmental Medicine administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the U.S. Department of Energy and USAMRMC. NR 20 TC 6 Z9 6 U1 0 U2 2 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD JUL PY 2012 VL 177 IS 7 BP 840 EP 844 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA V33NZ UT WOS:000209026800013 PM 22808892 ER PT J AU Bastian, ND Fulton, LV Mitchell, R Pollard, W Wierschem, D Wilson, R AF Bastian, Nathaniel D. Fulton, Lawrence V. Mitchell, Robert Pollard, Wayne Wierschem, David Wilson, Ronald TI The Future of Vertical Lift: Initial Insights for Aircraft Capability and Medical Planning SO MILITARY MEDICINE LA English DT Article ID REQUIREMENTS; OPERATIONS AB The U.S. Army continues to evaluate capabilities associated with the Future of Vertical Lift (FVL) program-a futures program (with a time horizon of 15 years and beyond) intended to replace the current helicopter fleet. As part of the FVL study, we investigated required capabilities for future aeromedical evacuation platforms. This study presents two significant capability findings associated with the future aeromedical evacuation platform and one doctrinal finding associated with medical planning for future brigade operations. The three results follow: (1) Given simplifying assumptions and constraints for a scenario where a future brigade is operating in a 300 x 300 km(2), the zero-risk aircraft ground speed required for the FVL platform is 350 nautical miles per hour (knots); (2) Given these same assumptions and constraints with the future brigade projecting power in a circle of radius 150 km, the zero-risk ground speed required for the FVL platform is 260 knots; and (3) Given uncertain casualty locations associated with future brigade stability and support operations, colocating aeromedical evacuation assets and surgical elements mathematically optimizes the 60-minute set covering problem. C1 [Bastian, Nathaniel D.] US Army, Med Dept Ctr & Sch, Med Capabil Integrat Ctr, Ctr AMEDD Strateg Studies, Ft Sam Houston, TX 78234 USA. [Fulton, Lawrence V.; Wierschem, David] Texas State Univ, McCoy Coll Business Adm, Dept Comp Informat Syst & Quantitat Method, San Marcos, TX 78666 USA. [Mitchell, Robert] US Army, Med Dept Ctr & Sch, Med Capabil Integrat Ctr, Med Evacuat Proponency Directorate, Fort Rucker, AL 36362 USA. [Pollard, Wayne; Wilson, Ronald] Navigator Dev Grp, Enterprise, AL 36330 USA. RP Bastian, ND (reprint author), US Army, Med Dept Ctr & Sch, Med Capabil Integrat Ctr, Ctr AMEDD Strateg Studies, Ft Sam Houston, TX 78234 USA. FU Medical Evacuation Proponency Directorate of the Medical Capabilities Integration Center of the U.S. Army Medical Department Center & School, Fort Rucker, AL FX We thank the Medical Evacuation Proponency Directorate of the Medical Capabilities Integration Center of the U.S. Army Medical Department Center & School, Fort Rucker, AL, who funded the research and analysis of this study. NR 12 TC 4 Z9 4 U1 1 U2 2 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD JUL PY 2012 VL 177 IS 7 BP 863 EP 869 PG 7 WC Medicine, General & Internal SC General & Internal Medicine GA V33NZ UT WOS:000209026800017 PM 22808896 ER PT J AU Arseneau, CAM Hrabak, TM Weibel, KH AF Arseneau, Capt April M. Hrabak, Todd M. Weibel, Kirk H. TI Inhalant Horse Allergens and Allergies: A Review of the Literature SO MILITARY MEDICINE LA English DT Review AB A wealth of literature exists regarding common allergies to household pets such as cat or dog. Allergy to horse, however, is infrequently discussed in the medical literature despite significant sensitization rates among urban-dwelling subjects without direct exposure to horses. A literature search was conducted in PubMed and additional references were collected from surveying the references of the pulled articles. This review summarizes aspects of IgE-mediated horse allergy including the prevalence and mechanisms for sensitization, clinical presentation, molecular characterization of the major and minor horse allergens, and the role of allergen immunotherapy. There is currently only one horse immunotherapy study showing significant improvement in clinically sensitive patients. The 1997 World Health Organization Position Paper on Immunotherapy lists horse immunotherapy among the areas needing further clinical research. Inclusion of horse into the standard allergen panel for children and adults has been supported by several authors, although further identification and characterization of horse antigens is needed to provide the most efficacious extract. As clinicians, we need to be aware of the potential cross-reactivity among the common mammalian allergens and consider the possibility of known or occult exposure to horse as a possible source of symptom exacerbation in susceptible individuals. C1 [Arseneau, Capt April M.] Wilford Hall USAF Med Ctr, Dept Allergy & Immunol, Lackland AFB, TX 78236 USA. [Hrabak, Todd M.] Desert Ctr Allergy & Chest Dis, Phoenix, AZ 85032 USA. [Weibel, Kirk H.] Brooke Army Med Ctr, Dept Allergy & Immunol, Ft Sam Houston, TX 78234 USA. RP Arseneau, CAM (reprint author), Wilford Hall USAF Med Ctr, Dept Allergy & Immunol, 2200 Bergquist Dr,Suite 1, Lackland AFB, TX 78236 USA. NR 51 TC 0 Z9 0 U1 1 U2 1 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD JUL PY 2012 VL 177 IS 7 BP 877 EP 882 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA V33NZ UT WOS:000209026800019 ER PT J AU Rahman, MM Zainuddin, S Hosur, MV Malone, JE Salam, MBA Kumar, A Jeelani, S AF Rahman, M. M. Zainuddin, S. Hosur, M. V. Malone, J. E. Salam, M. B. A. Kumar, Ashok Jeelani, S. TI Improvements in mechanical and thermo-mechanical properties of e-glass/epoxy composites using amino functionalized MWCNTs SO COMPOSITE STRUCTURES LA English DT Article DE Functionalized MWCNTs; Sonication; Calendaring; Mechanical and thermo-mechanical properties ID FIBER-REINFORCED COMPOSITES; WALLED CARBON NANOTUBES; ELECTRICAL-PROPERTIES; EPOXY NANOCOMPOSITES; PHYSICAL-PROPERTIES; DISPERSION; MATRIX; STRENGTH AB The prime objective of this work is to optimize the mechanical and thermo-mechanical properties of e-glass/epoxy composites by utilizing amino-functionalized multi-walled carbon nanotubes (MWCNTs-NH2) through a combination of dispersion method. At first, 0.1-0.4 wt.% of MWCNT-NH2 was integrated into SC-15 epoxy suspension using a combination of ultra-sonication and calendaring techniques. E-glass/epoxy nanocomposites were than fabricated at elevated temperature with the modified resin using hand layup and compression hot press. 3-Point flexural and dynamic mechanical analysis (DMA) results demonstrated a linearly increasing trend in properties from 0 to 0.3 wt.% loading. Micrographs of MWCNTs incorporated epoxy and e-glass/epoxy samples revealed uniform dispersion of MWCNTs in epoxy, good interfacial adhesion between CNTs and polymer, and improved interfacial bonding between fiber/matrix at 0.3 wt.% loading. An improved dispersion and hence an improved cross-link interaction between MWCNT-NH2 and epoxy lead to the stronger shift of the mechanical and thermo-mechanical properties of the composites. (c) 2012 Elsevier Ltd. All rights reserved. C1 [Zainuddin, S.; Hosur, M. V.; Jeelani, S.] Tuskegee Univ, Dept Mat Sci & Engn, Tuskegee, AL 36088 USA. [Rahman, M. M.; Malone, J. E.; Salam, M. B. A.] Tuskegee Univ, Dept Mech Engn, Tuskegee, AL 36088 USA. [Kumar, Ashok] USA, Construct Engn Res Lab, Engineer Res & Dev Ctr, Champaign, IL 61821 USA. RP Zainuddin, S (reprint author), Tuskegee Univ, Dept Mat Sci & Engn, Tuskegee, AL 36088 USA. EM szainuddin@mytu.tuskegee.edu FU US Engineer Research Development Corporation - Construction Engineering Research Laboratory (ERDC-CERL); NASA-EPSCoR FX The authors would like to acknowledge US Engineer Research Development Corporation - Construction Engineering Research Laboratory (ERDC-CERL) and NASA-EPSCoR for funding this work. NR 29 TC 46 Z9 48 U1 0 U2 22 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0263-8223 J9 COMPOS STRUCT JI Compos. Struct. PD JUL PY 2012 VL 94 IS 8 BP 2397 EP 2406 DI 10.1016/j.compstruct.2012.03.014 PG 10 WC Materials Science, Composites SC Materials Science GA 952LD UT WOS:000304793100015 ER PT J AU Ezzati, M Horwitz, MEM Thomas, DSK Friedman, AB Roach, R Clark, T Murray, CJL Honigman, B AF Ezzati, Majid Horwitz, Mara E. M. Thomas, Deborah S. K. Friedman, Ari B. Roach, Robert Clark, Timothy Murray, Christopher J. L. Honigman, Benjamin TI Altitude, life expectancy and mortality from ischaemic heart disease, stroke, COPD and cancers: national population-based analysis of US counties SO JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH LA English DT Article ID OBSTRUCTIVE PULMONARY-DISEASE; UNITED-STATES; CARDIOVASCULAR MORTALITY; MYOCARDIAL-INFARCTION; BLOOD-PRESSURE; LUNG-CANCER; VITAMIN-D; HYPOXIA; PREVALENCE; STATISTICS AB Background There is a substantial variation in life expectancy across US counties, primarily owing to differentials in chronic diseases. The authors' aim was to examine the association of life expectancy and mortality from selected diseases with altitude. Methods The authors used data from the National Elevation Dataset, National Center for Heath Statistics and US Census. The authors analysed the crude association of mean county altitude with life expectancy and mortality from ischaemic heart disease (IHD), stroke, chronic obstructive pulmonary disease (COPD) and cancers, and adjusted the associations for sociodemographic factors, migration, average annual solar radiation and cumulative exposure to smoking in multivariable regressions. Results Counties above 1500 m had longer life expectancies than those within 100 m of sea level by 1.2-3.6 years for men and 0.5-2.5 years for women. The association between altitude and life expectancy became non-significant for women and non-significant or negative for men in multivariate analysis. After adjustment, altitude had a beneficial association with IHD mortality and harmful association with COPD, with a dose-response relationship. IHD mortality above 1000 m was 4-14 per 10 000 people lower than within 100 m of sea level; COPD mortality was higher by 3-4 per 10 000. The adjusted associations for stroke and cancers were not statistically significant. Conclusions Living at higher altitude may have a protective effect on IHD and a harmful effect on COPD. At least in part due to these two opposing effects, living at higher altitude appears to have no net effect on life expectancy. C1 [Ezzati, Majid] Univ London Imperial Coll Sci Technol & Med, Dept Epidemiol & Biostatist, MRC HPA Ctr Environm & Hlth, Sch Publ Hlth, London W2 1PG, England. [Horwitz, Mara E. M.] Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98195 USA. [Thomas, Deborah S. K.] Univ Colorado Denver, Dept Geog & Environm Sci, Denver, CO USA. [Friedman, Ari B.] Univ Penn, Philadelphia, PA 19104 USA. [Roach, Robert; Honigman, Benjamin] Univ Colorado Denver, Sch Med, Altitude Res Ctr, Aurora, CO USA. [Roach, Robert; Honigman, Benjamin] Univ Colorado Denver, Sch Med, Dept Emergency Med, Aurora, CO USA. [Clark, Timothy] USA, Corps Engineers Engn Res & Dev Ctr, Topog Engn Ctr, Alexandria, VA USA. RP Ezzati, M (reprint author), Univ London Imperial Coll Sci Technol & Med, Dept Epidemiol & Biostatist, MRC HPA Ctr Environm & Hlth, Sch Publ Hlth, St Marys Campus,Norfolk Pl, London W2 1PG, England. EM majid.ezzati@imperial.ac.uk RI Friedman, Ari/J-6528-2013; bebarta, vikhyat/K-3476-2015 OI Friedman, Ari/0000-0003-0412-6754; FU Centers for Disease Control and Prevention (CDC) through the Association of Schools of Public Health (ASPH) [U36/CCU300430-23]; Altitude Research Center; MRC-HPA Centre for Environmental and Health, Imperial College London FX The study was supported by the Centers for Disease Control and Prevention (CDC) through the Association of Schools of Public Health (ASPH) (Grant No U36/CCU300430-23), the Altitude Research Center and MRC-HPA Centre for Environmental and Health, Imperial College London. NR 50 TC 21 Z9 22 U1 0 U2 9 PU B M J PUBLISHING GROUP PI LONDON PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND SN 0143-005X J9 J EPIDEMIOL COMMUN H JI J. Epidemiol. Community Health PD JUL PY 2012 VL 66 IS 7 AR e17 DI 10.1136/jech.2010.112938 PG 8 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 954CD UT WOS:000304922600005 PM 21406589 ER PT J AU Brockmeyer, JR Simon, TE Jacob, RK Husain, F Choi, Y AF Brockmeyer, Joel R. Simon, Todd E. Jacob, Richard K. Husain, Farah Choi, Yong TI Upper Gastrointestinal Swallow Study Following Bariatric Surgery: Institutional Review and Review of the Literature SO OBESITY SURGERY LA English DT Review DE Upper GI; Bariatric surgery; Radiology ID LAPAROSCOPIC GASTRIC BYPASS; UPPER GI SERIES; ROUTINE; LEAKS AB The aim of this study was to determine the efficacy of routine upper gastrointestinal imaging following the three forms of laparoscopic bariatric surgery completed at our institution (laparoscopic Roux en Y gastric bypass (LRYGB), laparoscopic sleeve gastrectomy (LS), and laparoscopic adjustable gastric banding (LAGB)). Radiograph reports were reviewed from the period of January 2005 to July 2010. During that time, 129 patients underwent LRYGB, 209 underwent LS, and 12 patients underwent LAGB. Of those patients, 120 LRYGB patients, 188 LS patients, and 11 LAGB patients underwent upper gastrointestinal studies on postoperative days (POD) 1 or 2. Of the 319 total patients who underwent UGI, no contrast leaks were found. One LRYGB patient was found to have stenosis of the jejunojejunal anastomosis and was taken to the operating room for revision. A total of ten patients went on to develop leaks: four LRYGB patients, six LS patients, and zero LAGB patients. The results of our study show that a positive UGI study for stricture has a specificity of 100 %. In terms of leak, which offers a much higher risk of significant morbidity and mortality, UGI was unable to find any on postoperative days 1 or 2. Based on the results of this study, our institution has stopped completing routine UGI on POD 1 following bariatric surgery. C1 [Brockmeyer, Joel R.; Simon, Todd E.; Jacob, Richard K.; Husain, Farah; Choi, Yong] Dwight D Eisenhower Army Med Ctr, Ft Gordon, GA 30905 USA. RP Brockmeyer, JR (reprint author), Dwight D Eisenhower Army Med Ctr, 300 Hosp Rd, Ft Gordon, GA 30905 USA. EM joel.r.brockmeyer@gmail.com NR 14 TC 22 Z9 22 U1 0 U2 2 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0960-8923 J9 OBES SURG JI Obes. Surg. PD JUL PY 2012 VL 22 IS 7 BP 1039 EP 1043 DI 10.1007/s11695-012-0658-4 PG 5 WC Surgery SC Surgery GA 953PX UT WOS:000304884200007 PM 22527600 ER PT J AU Stark, S Chernyshenko, OS Drasgow, F White, LA AF Stark, Stephen Chernyshenko, Oleksandr S. Drasgow, Fritz White, Leonard A. TI Adaptive Testing With Multidimensional Pairwise Preference Items: Improving the Efficiency of Personality and Other Noncognitive Assessments SO ORGANIZATIONAL RESEARCH METHODS LA English DT Article DE item response theory; IRT; computerized adaptive testing; CAT; ideal point; pairwise preference; multidimensional forced choice ID FORCED-CHOICE; JOB-PERFORMANCE; PERSONNEL-SELECTION; COGNITIVE-ABILITY; BIG 5; FAKING; MODEL; VALIDITY; FORMATS; SCALES AB Assessment of noncognitive constructs in organizational research and practice is challenging because of response biases that can distort test scores. Researchers must also deal with time constraints and the ensuing trade-offs between test length and the number of constructs measured. This article describes a novel way of improving the efficiency of noncognitive assessments using computer adaptive testing (CAT) with multidimensional pairwise preference (MDPP) items. Tests composed of MDPP items are part of a broader family of forced choice measures that ask respondents to choose between two or more equally desirable statements in an effort to combat response distortion. The authors conducted four computer simulations to explore the influences of test design, dimensionality, and the advantages of adaptive item selection for trait score and error estimation with tests involving as many as 25 dimensions. Overall, adaptive MDPP testing produced gains in accuracy over nonadaptive MDPP tests comparable to those observed with traditional unidimensional CATs. In addition, an empirical illustration involving a 15-dimension MDPP CAT administered in a field setting showed patterns of correlations that were consistent with expectations, thus showing construct validity. C1 [Stark, Stephen] Univ S Florida, Dept Psychol, Tampa, FL 33620 USA. [Chernyshenko, Oleksandr S.] Nanyang Technol Univ, Nanyang Business Sch, Div Strategy Management & Org, Singapore, Singapore. [Drasgow, Fritz] Univ Illinois, Dept Psychol, Champaign, IL USA. [White, Leonard A.] USA, Res Inst Behav & Social Sci, Arlington, VA USA. RP Stark, S (reprint author), Univ S Florida, Dept Psychol, 4202 E Fowler Ave,PCD 4118G, Tampa, FL 33620 USA. EM sestark@usf.edu NR 61 TC 19 Z9 20 U1 3 U2 30 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 1094-4281 J9 ORGAN RES METHODS JI Organ. Res. Methods PD JUL PY 2012 VL 15 IS 3 BP 463 EP 487 DI 10.1177/1094428112444611 PG 25 WC Psychology, Applied; Management SC Psychology; Business & Economics GA 955HP UT WOS:000305008300006 ER PT J AU Levine, F Escarsega, J La Scala, J AF Levine, Felicia Escarsega, John La Scala, John TI Effect of isocyanate to hydroxyl index on the properties of clear polyurethane films SO PROGRESS IN ORGANIC COATINGS LA English DT Review DE Polyurethane; Isocyanate to hydroxyl ratio; CARC; Crosslinking; Permeability; Tensile testing ID WATERBORNE POLYURETHANES AB Clear polyurethane films were made from aqueous polyurethane pre-polymer dispersions and water-dispersible aliphatic isocyanate pre-polymer, varying the amount of isocyanate used to cure the films. Film series were made from one of two polyol dispersions; the control XP-7110 having a higher molecular weight and containing 10 wt.% n-methylpyrrolidone (nmp) was compared to a zero-volatile organic compound (VOC) lower molecular weight alternate polyol XP-2591. Increasing the relative number of isocyanate groups to hydroxyl groups in these films provided an increase in glass transition temperature (T-g), tensile strength, elastic modulus and improved barrier properties to dimethyl methylphosphonate (DMMP) for both polyols in this study. At all indices in this study XP-7110 films achieved slightly higher T-g and slightly better resistance to permeation by DMMP than the XP-2591 films. Water resistance of the films was not improved at higher indices nor was there any difference between the polyols. Yet, the experimental results suggest that it is possible to produce polyurethane binders with acceptable film properties while reducing the VOC content of the formulation by using t-butyl acetate as the isocyanate reducing solvent. The zero-VOC polyol achieved better tensile properties with higher indexing than the current polyol containing 10 wt.% VOC. While the zero-VOC polyol did not perform as well as the baseline polyol in some tests, the differences in performance were small and thus there may be an opportunity to use the zero-VOC polyol as a partial or even a complete replacement of the current material. (C) 2012 Elsevier B.V. All rights reserved. C1 [Levine, Felicia; Escarsega, John; La Scala, John] USA, Dept Army, Res Lab, RDRL WMM C, Aberdeen Proving Ground, MD 21005 USA. RP Levine, F (reprint author), USA, Dept Army, Res Lab, RDRL WMM C, Aberdeen Proving Ground, MD 21005 USA. EM felicia.levine@us.army.mil FU Strategic Environmental Research and Development Program (SERDP) [WP-1521] FX The authors would like to thank Faye R. Toulan (Army Research Laboratory) for her contributions to this research and the Strategic Environmental Research and Development Program (SERDP WP-1521) for funding this study. NR 26 TC 5 Z9 6 U1 5 U2 61 PU ELSEVIER SCIENCE SA PI LAUSANNE PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND SN 0300-9440 J9 PROG ORG COAT JI Prog. Org. Coat. PD JUL PY 2012 VL 74 IS 3 BP 572 EP 581 DI 10.1016/j.porgcoat.2012.02.004 PG 10 WC Chemistry, Applied; Materials Science, Coatings & Films SC Chemistry; Materials Science GA 952MG UT WOS:000304796000020 ER PT J AU Schmidt, B Choisy, P Rahtman-Josserand, M AF Schmidt, B. Choisy, P. Rahtman-Josserand, M. TI Skin Regenerating Active Produced from Rosa Dedifferentiated Cell Culture SO IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL LA English DT Meeting Abstract C1 [Schmidt, B.] USA, LOreal Res & Innovat, Clark, NJ 08873 USA. [Choisy, P.] LOreal Res & Innovat, F-37097 Tours 2, France. [Rahtman-Josserand, M.] LOreal Res & Innovat, F-92583 Clichy, France. EM bschmidt@rd.us.loreal.com NR 0 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1071-2690 J9 IN VITRO CELL DEV-AN JI In Vitro Cell. Dev. Biol.-Anim. PD JUL PY 2012 VL 48 SU 1 BP 3 EP 4 PG 2 WC Cell Biology; Developmental Biology SC Cell Biology; Developmental Biology GA 947BU UT WOS:000304402400008 ER PT J AU Brennan, LM Widder, MW Lee, LEJ van der Schalie, WH AF Brennan, Linda M. Widder, Mark W. Lee, Lucy E. J. van der Schalie, William H. TI Long-term Storage and Impedance-based Water Toxicity Testing Capabilities of Fluidic Biochips Seeded with RTgill-W1 Cells SO IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL LA English DT Meeting Abstract C1 [Brennan, Linda M.; Widder, Mark W.; van der Schalie, William H.] USA, Ctr Environm Hlth Res, Ft Detrick, MD USA. [Lee, Lucy E. J.] Wilfrid Laurier Univ, Dept Biol, Waterloo, ON N2L 3C5, Canada. EM linda.brennan@us.army.mil; mark.widder@us.army.mil; llee@wlu.ca; william.vanderSchalie@us.army.mil RI Lee, Lucy/B-8849-2016 OI Lee, Lucy/0000-0003-1796-0588 NR 0 TC 0 Z9 0 U1 1 U2 2 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1071-2690 J9 IN VITRO CELL DEV-AN JI In Vitro Cell. Dev. Biol.-Anim. PD JUL PY 2012 VL 48 SU 1 BP 8 EP 9 PG 2 WC Cell Biology; Developmental Biology SC Cell Biology; Developmental Biology GA 947BU UT WOS:000304402400021 ER PT J AU Fridman, A Weber, S Graff, C Breen, DE Dandekar, KR Kam, M AF Fridman, Alex Weber, Steven Graff, Charles Breen, David E. Dandekar, Kapil R. Kam, Moshe TI OMAN: A Mobile Ad Hoc Network Design System SO IEEE TRANSACTIONS ON MOBILE COMPUTING LA English DT Article DE Cross-layer design; optimization; mobile ad hoc networks; simulation; software systems ID OPTIMIZATION AB We present a software library that aids in the design of mobile ad hoc networks (MANET). The OMAN design engine works by taking a specification of network requirements and objectives, and allocates resources which satisfy the input constraints and maximize the communication performance objective. The tool is used to explore networking design options and challenges, including: power control, adaptive modulation, flow control, scheduling, mobility, uncertainty in channel models, and cross-layer design. The unaddressed niche which OMAN seeks to fill is the general framework for optimization of any network resource, under arbitrary constraints, and with any selection of multiple objectives. While simulation is an important part of measuring the effectiveness of implemented optimization techniques, the novelty and focus of OMAN is on proposing novel network design algorithms, aggregating existing approaches, and providing a general framework for a network designer to test out new proposed resource allocation methods. In this paper, we present a high-level view of the OMAN architecture, review specific mathematical models used in the network representation, and show how OMAN is used to evaluate tradeoffs in MANET design. Specifically, we cover three case studies of optimization. The first case is robust power control under uncertain channel information for a single physical layer snapshot. The second case is scheduling with the availability of directional radiation patterns. The third case is optimizing topology through movement planning of relay nodes. C1 [Fridman, Alex; Kam, Moshe] Drexel Univ, Dept Elect & Comp Engn, DHS NSA Ctr Excellence Informat Assurance Educ, Philadelphia, PA 19104 USA. [Graff, Charles] USA, RDECOM, CERDEC, Ft Monmouth, NJ USA. [Breen, David E.] Drexel Univ, Dept Comp Sci, Philadelphia, PA 19104 USA. RP Fridman, A (reprint author), Drexel Univ, Dept Elect & Comp Engn, DHS NSA Ctr Excellence Informat Assurance Educ, Philadelphia, PA 19104 USA. RI Dandekar, Kapil/J-3055-2013 OI Dandekar, Kapil/0000-0003-1936-2514 FU US Army Communications-Electronics Research, Development and Engineering Center (CERDEC) [DAAB-07-01-9-L504] FX This work is funded by the US Army Communications-Electronics Research, Development and Engineering Center (CERDEC), under contract #DAAB-07-01-9-L504. NR 33 TC 6 Z9 6 U1 1 U2 7 PU IEEE COMPUTER SOC PI LOS ALAMITOS PA 10662 LOS VAQUEROS CIRCLE, PO BOX 3014, LOS ALAMITOS, CA 90720-1314 USA SN 1536-1233 J9 IEEE T MOBILE COMPUT JI IEEE. Trans. Mob. Comput. PD JUL PY 2012 VL 11 IS 7 BP 1179 EP 1191 DI 10.1109/TMC.2011.174 PG 13 WC Computer Science, Information Systems; Telecommunications SC Computer Science; Telecommunications GA 943TU UT WOS:000304148900009 ER PT J AU Nestrud, MA Ennis, JM Lawless, HT AF Nestrud, Michael A. Ennis, John M. Lawless, Harry T. TI A group level validation of the supercombinatorality property: Finding high-quality ingredient combinations using pairwise information SO FOOD QUALITY AND PREFERENCE LA English DT Article DE Combinations; Graph theory; Menus; Combinations; Pizza; Supercombinatorality ID PRODUCT DEVELOPMENT; CONSUMER-RESEARCH; CONJOINT-ANALYSIS; PURCHASE INTENT; FOODS; CLIQUES AB This study tested the principle of supercombinatorality, i.e. that food combinations (of more than two items) that are fully compatible on a pairwise basis are more compatible than combinations that are not fully compatible pairwise. Previous work has shown this to hold for salad ingredient combinations predicted for individuals, but this has not yet been tested for groups. This study extended the previous findings to group data, and in a different product system, namely pizza toppings. Purchase intent responses to pairs of 25 different pizza toppings were collected and used to predict pizzas (with 1-6 toppings) that would appeal to the entire group. Results showed purchase interest to be higher for the predicted pizzas than for non-predicted pizzas supporting the supercombinatorality principle. The study demonstrates that food product developers can use consumer-driven data and a graph theoretic approach to screen large numbers of potential food combinations in order to predict potentially successful combinations and to do so in a highly cost-efficient manner. Published by Elsevier Ltd. C1 [Nestrud, Michael A.] USA, Natick Res Dev & Engn Ctr, Natick, MA 01760 USA. [Ennis, John M.] Inst Percept, Richmond, VA 23235 USA. [Lawless, Harry T.] Cornell Univ, Dept Food Sci, Ithaca, NY 14853 USA. RP Nestrud, MA (reprint author), USA, Natick Res Dev & Engn Ctr, Natick, MA 01760 USA. EM mike@ataraxis.org; john.m.ennis@ifpress.com; harry.lawless@cornell.edu OI Nestrud, Michael/0000-0002-2423-6785 NR 25 TC 3 Z9 3 U1 0 U2 2 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0950-3293 J9 FOOD QUAL PREFER JI Food. Qual. Prefer. PD JUL PY 2012 VL 25 IS 1 BP 23 EP 28 DI 10.1016/j.foodqual.2012.01.003 PG 6 WC Food Science & Technology SC Food Science & Technology GA 925LT UT WOS:000302763400003 ER PT J AU Girgis, L Khan, KR Milovic, D Crutcher, SH Konar, S Biswas, A AF Girgis, Laila Khan, Kaisar R. Milovic, Daniela Crutcher, Sihon H. Konar, Swapan Biswas, Anjan TI Adiabatic phase variation for optical Gaussons SO OPTICS AND LASER TECHNOLOGY LA English DT Article DE Gaussons; Phase conservation; Perturbation ID LOG-LAW NONLINEARITY; SOLITON PERTURBATION; SCHRODINGER-EQUATION; MEDIA AB This paper studies the adiabatic phase variation of optical Gaussons in the presence of perturbation terms. The modified conservation law of phase variation is used to carry out this analysis. (C) 2012 Elsevier Ltd. All rights reserved. C1 [Girgis, Laila; Biswas, Anjan] Delaware State Univ, Dept Math Sci, Dover, DE 19901 USA. [Khan, Kaisar R.] Humber Coll, Sch Appl Technol, Toronto, ON M9W 5L7, Canada. [Milovic, Daniela] Univ Nis, Dept Telecommun, Fac Elect Engn, Nish 18000, Serbia. [Crutcher, Sihon H.] USA, Res Dev & Engn Command, Redstone Arsenal, AL 35898 USA. [Konar, Swapan] Birla Inst Technol, Dept Appl Phys, Ranchi 835215, Bihar, India. RP Biswas, A (reprint author), Delaware State Univ, Dept Math Sci, Dover, DE 19901 USA. EM biswas.anjan@gmail.com RI Biswas, Anjan /D-8500-2012 FU Serbian Ministry of Education and Science [III44006] FX The work of the third author (Daniela Milovic) presented here was supported by the Serbian Ministry of Education and Science (project III44006). NR 20 TC 5 Z9 5 U1 0 U2 0 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0030-3992 EI 1879-2545 J9 OPT LASER TECHNOL JI Opt. Laser Technol. PD JUL PY 2012 VL 44 IS 5 BP 1219 EP 1222 DI 10.1016/j.optlastec.2012.01.007 PG 4 WC Optics; Physics, Applied SC Optics; Physics GA 910BE UT WOS:000301611400005 ER PT J AU Sampath, R Mulholland, N Blyn, LB Massire, C Whitehouse, CA Waybright, N Harter, C Bogan, J Miranda, MS Smith, D Baldwin, C Wolcott, M Norwood, D Kreft, R Frinder, M Lovari, R Yasuda, I Matthews, H Toleno, D Housley, R Duncan, D Li, F Warren, R Eshoo, MW Hall, TA Hofstadler, SA Ecker, DJ AF Sampath, Rangarajan Mulholland, Niveen Blyn, Lawrence B. Massire, Christian Whitehouse, Chris A. Waybright, Nicole Harter, Courtney Bogan, Joseph Miranda, Mary Sue Smith, David Baldwin, Carson Wolcott, Mark Norwood, David Kreft, Rachael Frinder, Mark Lovari, Robert Yasuda, Irene Matthews, Heather Toleno, Donna Housley, Roberta Duncan, David Li, Feng Warren, Robin Eshoo, Mark W. Hall, Thomas A. Hofstadler, Steven A. Ecker, David J. TI Comprehensive Biothreat Cluster Identification by PCR/Electrospray-Ionization Mass Spectrometry SO PLOS ONE LA English DT Article ID TANDEM REPEAT ANALYSIS; YERSINIA-PESTIS; GENETIC-RELATIONSHIPS; RAPID IDENTIFICATION; UNIVERSAL BIOSENSOR; GENOME SEQUENCE; BACILLUS; PLAGUE; VIRUS; PSEUDOTUBERCULOSIS AB Technology for comprehensive identification of biothreats in environmental and clinical specimens is needed to protect citizens in the case of a biological attack. This is a challenge because there are dozens of bacterial and viral species that might be used in a biological attack and many have closely related near-neighbor organisms that are harmless. The biothreat agent, along with its near neighbors, can be thought of as a biothreat cluster or a biocluster for short. The ability to comprehensively detect the important biothreat clusters with resolution sufficient to distinguish the near neighbors with an extremely low false positive rate is required. A technological solution to this problem can be achieved by coupling biothreat group-specific PCR with electrospray ionization mass spectrometry (PCR/ESI-MS). The biothreat assay described here detects ten bacterial and four viral biothreat clusters on the NIAID priority pathogen and HHS/USDA select agent lists. Detection of each of the biothreat clusters was validated by analysis of a broad collection of biothreat organisms and near neighbors prepared by spiking biothreat nucleic acids into nucleic acids extracted from filtered environmental air. Analytical experiments were carried out to determine breadth of coverage, limits of detection, linearity, sensitivity, and specificity. Further, the assay breadth was demonstrated by testing a diverse collection of organisms from each biothreat cluster. The biothreat assay as configured was able to detect all the target organism clusters and did not misidentify any of the near-neighbor organisms as threats. Coupling biothreat cluster-specific PCR to electrospray ionization mass spectrometry simultaneously provides the breadth of coverage, discrimination of near neighbors, and an extremely low false positive rate due to the requirement that an amplicon with a precise base composition of a biothreat agent be detected by mass spectrometry. C1 [Sampath, Rangarajan; Blyn, Lawrence B.; Massire, Christian; Kreft, Rachael; Frinder, Mark; Lovari, Robert; Yasuda, Irene; Matthews, Heather; Toleno, Donna; Housley, Roberta; Duncan, David; Li, Feng; Warren, Robin; Eshoo, Mark W.; Hall, Thomas A.; Hofstadler, Steven A.; Ecker, David J.] Abbott, Ibis Biosci, Carlsbad, CA 92008 USA. [Mulholland, Niveen; Waybright, Nicole; Harter, Courtney; Bogan, Joseph] MRIGlobal, Rockville, MD USA. [Whitehouse, Chris A.; Baldwin, Carson; Wolcott, Mark; Norwood, David] USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. [Miranda, Mary Sue; Smith, David] Pentagon Force Protect Agcy, Lab Div, Chem Biol Radiol Nucl & Explos Directorate, Washington, DC USA. RP Sampath, R (reprint author), Abbott, Ibis Biosci, Carlsbad, CA 92008 USA. EM rangarajan.sampath@abbott.com FU Defense Advanced Research Projects Agency (DARPA) [MDA972-00-C-0053]; Centers for Disease Control and Prevention (CDC) [1R01-C1000099]; Department of Homeland Security (DHS) [NBCHC070019]; Ibis; Department of Homeland Security FX The authors acknowledge the Defense Advanced Research Projects Agency (DARPA: Contract MDA972-00-C-0053) and the Centers for Disease Control and Prevention (CDC: Contract 1R01-C1000099) for financial support to develop the hardware platform, and the Department of Homeland Security (DHS: Contract NBCHC070019) for support of the biothreat assay validation. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.; R.S. and other authors with affiliation listed as Ibis Biosciences Inc., are employees of Ibis Biosciences, a subsidiary of Abbott Molecular, Inc., which manufactures the instruments and reagents used in this study. N.M. and other authors with affiliations listed as MRIGlobal are employees of MRIGlobal, an independent, not-for-profit contract research organization that was funded by Ibis and the Department of Homeland Security to carry out the validation studies. The opinions, interpretations, conclusions, and recommendations are those of the authors and are not necessarily endorsed by the United States Army or the Pentagon Force Protection Agency. NR 48 TC 18 Z9 19 U1 1 U2 7 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD JUN 29 PY 2012 VL 7 IS 6 AR e36528 DI 10.1371/journal.pone.0036528 PG 16 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 967FO UT WOS:000305892100003 PM 22768032 ER PT J AU Benight, SJ Knorr, DB Johnson, LE Sullivan, PA Lao, D Sun, JN Kocherlakota, LS Elangovan, A Robinson, BH Overney, RM Dalton, LR AF Benight, Stephanie J. Knorr, Daniel B., Jr. Johnson, Lewis E. Sullivan, Philip A. Lao, David Sun, Jianing Kocherlakota, Lakshmi S. Elangovan, Arumugasamy Robinson, Bruce H. Overney, Rene M. Dalton, Larry R. TI Nano-Engineering Lattice Dimensionality for a Soft Matter Organic Functional Material SO ADVANCED MATERIALS LA English DT Article DE soft matter; electro-optics; molecular dynamics; dimensionality; intermolecular interactions ID NONLINEAR-OPTICAL CHROMOPHORES; ELECTROOPTIC ACTIVITY; FORCE MICROSCOPY; LIQUID-CRYSTALS; POLYMER-FILMS; GLASS; FRICTION; DESIGN; FIELD AB A high performing electro-optic ( EO) chromophore with covalently attached coumarin-based pendant groups exhibits intermolecular correlation of coumarin units through molecular dynamics ( MD) simulations. Unique, orthogonal molecular orientations of the chromophore and coumarin units are also evident when investigated optically. Such molecular orientation translates to reduced lattice dimensionality of the bulk C1 soft matter material system, leading to increased acentric order and EO activity. Results are corroborated by nanorheological experimental methods. C1 [Benight, Stephanie J.; Johnson, Lewis E.; Sullivan, Philip A.; Lao, David; Elangovan, Arumugasamy; Robinson, Bruce H.; Dalton, Larry R.] Univ Washington, Dept Chem, Seattle, WA 98195 USA. [Knorr, Daniel B., Jr.] USA, Res Lab, Macromol Sci & Technol Branch, Aberdeen Proving Ground, MD 21009 USA. [Kocherlakota, Lakshmi S.; Overney, Rene M.] Univ Washington, Dept Chem Engn, Seattle, WA 98195 USA. [Sun, Jianing] JA Woollam Co, Lincoln, NE 68508 USA. RP Dalton, LR (reprint author), Univ Washington, Dept Chem, Box 351700, Seattle, WA 98195 USA. EM Dalton@chem.washington.edu FU National Science Foundation; Air Force Office of Scientific Research FX The National Science Foundation and Air Force Office of Scientific Research are acknowledged for funding. Bruce Eichinger is acknowledged for useful discussions. Portions of this work appeared in the PhD Dissertation of Stephanie J Benight, Department of Chemistry, University of Washington, August 2011. NR 30 TC 13 Z9 13 U1 2 U2 58 PU WILEY-V C H VERLAG GMBH PI WEINHEIM PA BOSCHSTRASSE 12, D-69469 WEINHEIM, GERMANY SN 0935-9648 J9 ADV MATER JI Adv. Mater. PD JUN 26 PY 2012 VL 24 IS 24 BP 3263 EP 3268 DI 10.1002/adma.201104949 PG 6 WC Chemistry, Multidisciplinary; Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied; Physics, Condensed Matter SC Chemistry; Science & Technology - Other Topics; Materials Science; Physics GA 961FV UT WOS:000305450500016 PM 22605547 ER PT J AU Fisher, NA Ribot, WJ Applefeld, W DeShazer, D AF Fisher, Nathan A. Ribot, Wilson J. Applefeld, Willard DeShazer, David TI The Madagascar hissing cockroach as a novel surrogate host for Burkholderia pseudomallei, B. mallei and B. thailandensis SO BMC MICROBIOLOGY LA English DT Article DE Pathogenesis; Melioidosis; Glanders; Virulence; Surrogate host; Type VI secretion system ID VIRULENCE DETERMINANT; VI SECRETION; SYSTEM; IDENTIFICATION; GENE; MELIOIDOSIS; MUTAGENESIS; INFECTION; INSECT; MODELS AB Background: Burkholderia pseudomallei and Burkholderia mallei are gram-negative pathogens responsible for the diseases melioidosis and glanders, respectively. Both species cause disease in humans and animals and have been designated as category B select agents by the Centers for Disease Control and Prevention (CDC). Burkholderia thailandensis is a closely related bacterium that is generally considered avirulent for humans. While it can cause disease in rodents, the B. thailandensis 50% lethal dose (LD50) is typically >= 10(4)-fold higher than the B. pseudomallei and B. mallei LD50 in mammalian models of infection. Here we describe an alternative to mammalian hosts in the study of virulence and host-pathogen interactions of these Burkholderia species. Results: Madagascar hissing cockroaches (MH cockroaches) possess a number of qualities that make them desirable for use as a surrogate host, including ease of breeding, ease of handling, a competent innate immune system, and the ability to survive at 37 degrees C. MH cockroaches were highly susceptible to infection with B. pseudomallei, B. mallei and B. thailandensis and the LD50 was < 10 colony-forming units (cfu) for all three species. In comparison, the LD50 for Escherichia coli in MH cockroaches was > 10(5) cfu. B. pseudomallei, B. mallei, and B. thailandensis cluster 1 type VI secretion system (T6SS-1) mutants were all attenuated in MH cockroaches, which is consistent with previous virulence studies conducted in rodents. B. pseudomallei mutants deficient in the other five T6SS gene clusters, T6SS-2 through T6SS-6, were virulent in both MH cockroaches and hamsters. Hemocytes obtained from MH cockroaches infected with B. pseudomallei harbored numerous intracellular bacteria, suggesting that this facultative intracellular pathogen can survive and replicate inside of MH cockroach phagocytic cells. The hemolymph extracted from these MH cockroaches also contained multinuclear giant cells (MNGCs) with intracellular B. pseudomallei, which indicates that infected hemocytes can fuse while flowing through the insect's open circulatory system in vivo. Conclusions: The results demonstrate that MH cockroaches are an attractive alternative to mammals to study host-pathogen interactions and may allow the identification of new Burkholderia virulence determinants. The importance of T6SS-1 as a virulence factor in MH cockroaches and rodents suggests that the primary role of this secretion system is to target evasion of the innate immune system. C1 [Ribot, Wilson J.; Applefeld, Willard; DeShazer, David] USA, Bacteriol Div, Med Res Inst Infect Dis, Frederick, MD 21702 USA. [Fisher, Nathan A.] USA, Ctr Genom Sci, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. [Applefeld, Willard] Univ Maryland, Sch Med, Baltimore, MD 21201 USA. RP DeShazer, D (reprint author), USA, Bacteriol Div, Med Res Inst Infect Dis, 1425 Porter St,301, Frederick, MD 21702 USA. EM david.deshazer@us.army.mil OI Fisher, Nathan/0000-0002-2604-0719 FU DTRA/JSTO-CBD [CBS. MEDBIO.02.10.RD.034] FX This project received support from DTRA/JSTO-CBD proposal number CBS. MEDBIO.02.10.RD.034 (to D.D.). NR 42 TC 6 Z9 6 U1 0 U2 22 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1471-2180 J9 BMC MICROBIOL JI BMC Microbiol. PD JUN 22 PY 2012 VL 12 AR 117 DI 10.1186/1471-2180-12-117 PG 10 WC Microbiology SC Microbiology GA 000SF UT WOS:000308407800001 PM 22892068 ER PT J AU Yu, CG Desai, V Cheng, L Reifman, J AF Yu, Chenggang Desai, Valmik Cheng, Li Reifman, Jaques TI QuartetS-DB: a large-scale orthology database for prokaryotes and eukaryotes inferred by evolutionary evidence SO BMC BIOINFORMATICS LA English DT Article DE Orthologs; Orthology detection; Orthology database ID HIERARCHICAL CATALOG; GENE DUPLICATION; IDENTIFICATION; ANNOTATION; SEQUENCES; ALGORITHM; ORTHOMCL; PARALOGS; EGGNOG AB Background: The concept of orthology is key to decoding evolutionary relationships among genes across different species using comparative genomics. QuartetS is a recently reported algorithm for large-scale orthology detection. Based on the well-established evolutionary principle that gene duplication events discriminate paralogous from orthologous genes, QuartetS has been shown to improve orthology detection accuracy while maintaining computational efficiency. Description: QuartetS-DB is a new orthology database constructed using the QuartetS algorithm. The database provides orthology predictions among 1621 complete genomes (1365 bacterial, 92 archaeal, and 164 eukaryotic), covering more than seven million proteins and four million pairwise orthologs. It is a major source of orthologous groups, containing more than 300,000 groups of orthologous proteins and 236,000 corresponding gene trees. The database also provides over 500,000 groups of inparalogs. In addition to its size, a distinguishing feature of QuartetS-DB is the ability to allow users to select a cutoff value that modulates the balance between prediction accuracy and coverage of the retrieved pairwise orthologs. The database is accessible at https://applications.bioanalysis.org/quartetsdb. Conclusions: QuartetS-DB is one of the largest orthology resources available to date. Because its orthology predictions are underpinned by evolutionary evidence obtained from sequenced genomes, we expect its accuracy to continue to increase in future releases as the genomes of additional species are sequenced. C1 [Yu, Chenggang; Desai, Valmik; Cheng, Li; Reifman, Jaques] USA, US Dept Def, Biotechnol High Performance Comp Software Applica, Telemed & Adv Technol Res Ctr,Med Res & Mat Comma, Ft Detrick, MD 21702 USA. RP Reifman, J (reprint author), USA, US Dept Def, Biotechnol High Performance Comp Software Applica, Telemed & Adv Technol Res Ctr,Med Res & Mat Comma, Ft Detrick, MD 21702 USA. EM Jaques.Reifman@us.army.mil FU United States (U.S.) Department of Defense High Performance Computing Modernization Program under the High Performance Computing Software Applications Institutes Initiative FX This work was sponsored by the United States (U.S.) Department of Defense High Performance Computing Modernization Program, under the High Performance Computing Software Applications Institutes Initiative. Funding for open access charge is the same as the funding for the performed research. NR 25 TC 8 Z9 9 U1 0 U2 5 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1471-2105 J9 BMC BIOINFORMATICS JI BMC Bioinformatics PD JUN 22 PY 2012 VL 13 AR 143 DI 10.1186/1471-2105-13-143 PG 9 WC Biochemical Research Methods; Biotechnology & Applied Microbiology; Mathematical & Computational Biology SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology; Mathematical & Computational Biology GA 999YF UT WOS:000308350900001 PM 22726705 ER PT J AU Sholukh, AM Mukhtar, MM Humbert, M Essono, SS Watkins, JD Vyas, HK Shanmuganathan, V Hemashettar, G Kahn, M Hu, SL Montefiori, DC Polonis, VR Schur, PH Ruprecht, RM AF Sholukh, Anton M. Mukhtar, Muhammad M. Humbert, Michael Essono, Sosthene S. Watkins, Jennifer D. Vyas, Hemant K. Shanmuganathan, Vivekanandan Hemashettar, Girish Kahn, Maria Hu, Shiu-Lok Montefiori, David C. Polonis, Victoria R. Schur, Peter H. Ruprecht, Ruth M. TI Isolation of Monoclonal Antibodies with Predetermined Conformational Epitope Specificity SO PLOS ONE LA English DT Article ID IMMUNODEFICIENCY-VIRUS TYPE-1; HUMAN IMMUNE-RESPONSE; CLADE-C ENV; NEUTRALIZING ANTIBODIES; REPLICATION-COMPETENT; RHESUS MACAQUES; CD4 BINDING; B-CELLS; HIV-1; INFECTION AB Existing technologies allow isolating antigen-specific monoclonal antibodies (mAbs) from B cells. We devised a direct approach to isolate mAbs with predetermined conformational epitope specificity, using epitope mimetics (mimotopes) that reflect the three-dimensional structure of given antigen subdomains. We performed differential biopanning using bacteriophages encoding random peptide libraries and polyclonal antibodies (Abs) that had been affinity-purified with either native or denatured antigen. This strategy yielded conformational mimotopes. We then generated mimotope-fluorescent protein fusions, which were used as baits to isolate single memory B cells from rhesus monkeys (RMs). To amplify RM immunoglobulin variable regions, we developed RM-specific PCR primers and generated chimeric simian-human mAbs with predicted epitope specificity. We established proof-of-concept of our strategy by isolating mAbs targeting the conformational V3 loop crown of HIV Env; the new mAbs cross-neutralized viruses of different clades. The novel technology allows isolating mAbs from RMs or other hosts given experimental immunogens or infectious agents. C1 [Sholukh, Anton M.; Mukhtar, Muhammad M.; Humbert, Michael; Essono, Sosthene S.; Watkins, Jennifer D.; Vyas, Hemant K.; Shanmuganathan, Vivekanandan; Hemashettar, Girish; Ruprecht, Ruth M.] Dana Farber Canc Inst, Dept Canc Immunol, Boston, MA 02115 USA. [Sholukh, Anton M.; Mukhtar, Muhammad M.; Humbert, Michael; Essono, Sosthene S.; Watkins, Jennifer D.; Vyas, Hemant K.; Shanmuganathan, Vivekanandan; Hemashettar, Girish; Ruprecht, Ruth M.] Dana Farber Canc Inst, AIDS, Boston, MA 02115 USA. [Sholukh, Anton M.; Mukhtar, Muhammad M.; Humbert, Michael; Essono, Sosthene S.; Watkins, Jennifer D.; Vyas, Hemant K.; Schur, Peter H.; Ruprecht, Ruth M.] Harvard Univ, Sch Med, Boston, MA USA. [Kahn, Maria; Hu, Shiu-Lok] Univ Washington, Dept Pharmaceut, Seattle, WA 98195 USA. [Hu, Shiu-Lok] Univ Washington, Dept Microbiol, Seattle, WA 98195 USA. [Montefiori, David C.] Duke Univ, Sch Med, Dept Surg, Durham, NC USA. [Polonis, Victoria R.] Walter Reed Army Inst Res, Mil HIV Res Program, Silver Spring, MD USA. [Schur, Peter H.] Brigham & Womens Hosp, Dept Rheumatol Immunol & Allergy, Boston, MA 02115 USA. RP Sholukh, AM (reprint author), Dana Farber Canc Inst, Dept Canc Immunol, Boston, MA 02115 USA. EM ruth_ruprecht@dfci.harvard.edu RI Hu, Shiu-Lok/A-3196-2008 OI Hu, Shiu-Lok/0000-0003-4336-7964 FU NIH [P01 AI048240, P01 AI048240-08s1, R37 AI034266, P30 AI060354] FX This work was supported by NIH grants P01 AI048240, P01 AI048240-08s1, R37 AI034266, and P30 AI060354. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 37 TC 4 Z9 4 U1 0 U2 7 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD JUN 21 PY 2012 VL 7 IS 6 AR e38943 DI 10.1371/journal.pone.0038943 PG 11 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 964KY UT WOS:000305695100023 PM 22737224 ER PT J AU Hu, SW Maschal, R Young, SS Hong, TH Phillips, PJ AF Hu, Shuowen Maschal, Robert Young, S. Susan Hong, Tsai Hong Phillips, P. Jonathon TI Face recognition performance with superresolution SO APPLIED OPTICS LA English DT Article AB With the prevalence of surveillance systems, face recognition is crucial to aiding the law enforcement community and homeland security in identifying suspects and suspicious individuals on watch lists. However, face recognition performance is severely affected by the low face resolution of individuals in typical surveillance footage, oftentimes due to the distance of individuals from the cameras as well as the small pixel count of low-cost surveillance systems. Superresolution image reconstruction has the potential to improve face recognition performance by using a sequence of low-resolution images of an individual's face in the same pose to reconstruct a more detailed high-resolution facial image. This work conducts an extensive performance evaluation of superresolution for a face recognition algorithm using a methodology and experimental setup consistent with real world settings at multiple subject-to-camera distances. Results show that superresolution image reconstruction improves face recognition performance considerably at the examined midrange and close range. C1 [Hu, Shuowen; Maschal, Robert; Young, S. Susan] USA, Res Lab, Adelphi, MD 20783 USA. [Hong, Tsai Hong; Phillips, P. Jonathon] NIST, Gaithersburg, MD 20899 USA. RP Hu, SW (reprint author), USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM shuowen.hu.civ@mail.mil NR 16 TC 2 Z9 2 U1 0 U2 3 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1559-128X EI 2155-3165 J9 APPL OPTICS JI Appl. Optics PD JUN 20 PY 2012 VL 51 IS 18 BP 4250 EP 4259 DI 10.1364/AO.51.004250 PG 10 WC Optics SC Optics GA 970AH UT WOS:000306100000037 PM 22722306 ER PT J AU Reeder, DM Frank, CL Turner, GG Meteyer, CU Kurta, A Britzke, ER Vodzak, ME Darling, SR Stihler, CW Hicks, AC Jacob, R Grieneisen, LE Brownlee, SA Muller, LK Blehert, DS AF Reeder, DeeAnn M. Frank, Craig L. Turner, Gregory G. Meteyer, Carol U. Kurta, Allen Britzke, Eric R. Vodzak, Megan E. Darling, Scott R. Stihler, Craig W. Hicks, Alan C. Jacob, Roymon Grieneisen, Laura E. Brownlee, Sarah A. Muller, Laura K. Blehert, David S. TI Frequent Arousal from Hibernation Linked to Severity of Infection and Mortality in Bats with White-Nose Syndrome SO PLOS ONE LA English DT Article ID MYOTIS-LUCIFUGUS; VESPERTILIONID BATS; EMERGING DISEASE; METABOLIC-RATE; BROWN BATS; TEMPERATURE; PATTERNS; DURATION; TORPOR; GROWTH AB White-nose syndrome (WNS), an emerging infectious disease that has killed over 5.5 million hibernating bats, is named for the causative agent, a white fungus (Geomyces destructans (Gd)) that invades the skin of torpid bats. During hibernation, arousals to warm (euthermic) body temperatures are normal but deplete fat stores. Temperature-sensitive dataloggers were attached to the backs of 504 free-ranging little brown bats (Myotis lucifugus) in hibernacula located throughout the northeastern USA. Dataloggers were retrieved at the end of the hibernation season and complete profiles of skin temperature data were available from 83 bats, which were categorized as: (1) unaffected, (2) WNS-affected but alive at time of datalogger removal, or (3) WNS-affected but found dead at time of datalogger removal. Histological confirmation of WNS severity (as indexed by degree of fungal infection) as well as confirmation of presence/absence of DNA from Gd by PCR was determined for 26 animals. We demonstrated that WNS-affected bats aroused to euthermic body temperatures more frequently than unaffected bats, likely contributing to subsequent mortality. Within the subset of WNS-affected bats that were found dead at the time of datalogger removal, the number of arousal bouts since datalogger attachment significantly predicted date of death. Additionally, the severity of cutaneous Gd infection correlated with the number of arousal episodes from torpor during hibernation. Thus, increased frequency of arousal from torpor likely contributes to WNS-associated mortality, but the question of how Gd infection induces increased arousals remains unanswered. C1 [Reeder, DeeAnn M.; Vodzak, Megan E.; Jacob, Roymon; Grieneisen, Laura E.; Brownlee, Sarah A.] Bucknell Univ, Dept Biol, Lewisburg, PA 17837 USA. [Frank, Craig L.] Fordham Univ, Dept Biol Sci, Armonk, NY USA. [Turner, Gregory G.] Pennsylvania Game Commiss, Harrisburg, PA USA. [Meteyer, Carol U.; Muller, Laura K.; Blehert, David S.] US Geol Survey, Natl Wildlife Hlth Ctr, Madison, WI USA. [Kurta, Allen] Eastern Michigan Univ, Dept Biol, Ypsilanti, MI 48197 USA. [Britzke, Eric R.] USA, Engineer Res & Dev Ctr, Vicksburg, MS USA. [Darling, Scott R.] Vermont Fish & Wildlife Dept, Rutland, VT USA. [Stihler, Craig W.] W Virginia Div Nat Resources, Elkins, WV USA. [Hicks, Alan C.] New York State Dept Environm Conservat, Albany, NY USA. RP Reeder, DM (reprint author), Bucknell Univ, Dept Biol, Lewisburg, PA 17837 USA. EM dreeder@bucknell.edu OI Reeder, DeeAnn/0000-0001-8651-2012 FU Northeast Association of Fish and Wildlife Agencies (NEAFWA); Pennsylvania Department of Conservation and Natural Resources; Woodtiger Fund; Bucknell University FX The temperature tracking portion of this study was supported by State Wildlife Grant funds awarded through the Northeast Association of Fish and Wildlife Agencies (NEAFWA) Regional Conservation Needs grant program to DMR. (PI), CLF, GGT, ACH, and ERB, by funds from the Pennsylvania Department of Conservation and Natural Resources and the Woodtiger Fund to DMR, and by Graduate Fellowships from Bucknell University to LEG, SAB, and RJ. This grant and its associated conservation activities are done to support implementation of a priority action of the State Wildlife Action Plans from members of the NEAFWA. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 36 TC 66 Z9 68 U1 18 U2 157 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD JUN 20 PY 2012 VL 7 IS 6 AR e38920 DI 10.1371/journal.pone.0038920 PG 10 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 964KK UT WOS:000305693200029 PM 22745688 ER PT J AU Jones, LC Lafferty, BJ Sparks, DL AF Jones, L. Camille Lafferty, Brandon J. Sparks, Donald L. TI Additive and Competitive Effects of Bacteria and Mn Oxides on Arsenite Oxidation Kinetics SO ENVIRONMENTAL SCIENCE & TECHNOLOGY LA English DT Article ID RAY-ABSORPTION SPECTROSCOPY; ARSENIC(III) OXIDATION; MINERAL/WATER INTERFACE; SYNTHETIC BIRNESSITE; ALCALIGENES-FAECALIS; OXIDIZING BACTERIA; MANGANESE OXIDES; PUBLIC-HEALTH; GENES; ADSORPTION AB Arsenic (As) is a redox-active metalloid whose toxicity and mobility in soil depend on oxidation state. Arsenite [As(III)] can be oxidized to arsenate [As(V)] by both minerals and microbes in soil however, the interaction between these abiotic and biotic processes is not well understood. In this study, the time dependency of As(III) oxidation by two heterotrophic soil bacteria (Agrobacterium tumefaciens and Pseudomonas fluorescens) and a poorly crystalline manganese (Mn) oxide mineral (delta-MnO2) was determined using batch experiments. The apparent rate of As(V) appearance in solution was greater for the combined batch experiments in which bacteria and delta-MnO2 were oxidizing As(III) at the same time than for either component alone. The additive effect of the mixed cell-delta-MnO2 system was consistent for short (<1 h) and long (24 h) term coincubation indicating that mineral surface inhibition by cells has little effect the As(III) oxidation rate. Surface interactions between cells and the mineral surface were indicated by sorption and pH-induced desorption results. Total sorption of As on the mineral was lower with bacteria present (16.1 +/- 0.8% As sorbed) and higher with delta-MnO2 alone (23.4 +/- 1%) and As was more easily desorbed from the cell-delta-MnO2 system than from delta-MnO2 alone. Therefore, the presence of bacteria inhibited As sorption and decreased the stability of sorbed As on delta-MnO2 even though As(III) was oxidized fastest in a mixed cell-delta-MnO2 system. The additive effect of biotic (As-oxidizing bacteria) and abiotic (delta-MnO2 mineral) oxidation processes in a system containing both oxidants suggests that mineral-only results may underestimate the oxidative capacity of natural systems with biotic and abiotic As(III) oxidation pathways. C1 [Jones, L. Camille; Lafferty, Brandon J.; Sparks, Donald L.] Univ Delaware, Dept Plant & Soil Sci, Newark, DE 19717 USA. [Lafferty, Brandon J.] US Army Corps Engineers, Engineer Res & Dev Ctr, Vicksburg, MS USA. RP Jones, LC (reprint author), Stanford Univ, Dept Environm Earth Syst Sci, Stanford, CA 94305 USA. EM l.camille.jones@gmail.com FU Delaware Environmental Institute Fellowship (Unidel Foundation); EPA Science to Achieve Results (STAR) graduate fellowship FX Thanks are due to Caroline Golt, Jerry Hendricks, Tom Hanson, Jeff Fuhrmann, Clara Chan, and Debbie Powell for laboratory assistance, and Olesya Lazareva and Sam Ying for manuscript help. We also acknowledge Richard Macur and Bill Inskeep, of the Department of Land Resources and Environmental Sciences at Montana State University, for providing bacteria. L.C.J. acknowledges her fellowships: the Delaware Environmental Institute Fellowship (Unidel Foundation) and the EPA Science to Achieve Results (STAR) graduate fellowship. We also acknowledge three anonymous reviewers for their constructive suggestions and comments on the manuscript. NR 40 TC 18 Z9 19 U1 6 U2 61 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0013-936X J9 ENVIRON SCI TECHNOL JI Environ. Sci. Technol. PD JUN 19 PY 2012 VL 46 IS 12 BP 6548 EP 6555 DI 10.1021/es204252f PG 8 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA 959OA UT WOS:000305320900017 PM 22642773 ER PT J AU Choi, KK AF Choi, K. K. TI Electromagnetic modeling of edge coupled quantum well infrared photodetectors SO JOURNAL OF APPLIED PHYSICS LA English DT Article AB Edge coupling through a 45 degrees facet is the standard approach in characterizing quantum well infrared photodetector materials. From the spectral responsivity, the material absorption coefficient can be deduced from a classical model. However, this classical model has not been closely examined by a rigorous theory. In this work, we apply finite element electromagnetic modeling to obtain the detector quantum efficiency under this geometry and compare the result with the classical prediction. Remarkably, we find that both models give the same result at this particular angle while they differ significantly at other angles. [http://dx.doi.org/10.1063/1.4729810] C1 USA, Res Lab, Adelphi, MD 20783 USA. RP Choi, KK (reprint author), USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. RI Choi, Kwong-Kit/K-9205-2013 NR 3 TC 5 Z9 5 U1 0 U2 12 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD JUN 15 PY 2012 VL 111 IS 12 AR 124507 DI 10.1063/1.4729810 PG 4 WC Physics, Applied SC Physics GA 966IV UT WOS:000305832100145 ER PT J AU Prokopenko, OV Krivorotov, IN Bankowski, E Meitzler, T Jaroch, S Tiberkevich, VS Slavin, AN AF Prokopenko, O. V. Krivorotov, I. N. Bankowski, E. Meitzler, T. Jaroch, S. Tiberkevich, V. S. Slavin, A. N. TI Spin-torque microwave detector with out-of-plane precessing magnetic moment SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID DYNAMICS AB Operation of a spin-torque microwave detector (STMD) in a weak perpendicular bias magnetic field has been studied theoretically. It is shown that in this geometry a novel dynamical regime of STMD operation, characterized by large-angle out-of-plane magnetization precession, can be realized. The excitation of the large-angle precession has threshold character and is possible only for input microwave currents exceeding a certain frequency-dependent critical value. The output voltage of an STMD increases with the frequency of the input signal but is virtually independent of its power. An STMD working in the regime of large-amplitude out-of-plane precession functions as a non-resonant threshold detector of low frequency microwave signals, due to the large nonlinear shift of its operating frequency. Therefore, it is particularly suitable for applications in microwave energy harvesting. (C) 2012 American Institute of Physics. [http://dx.doi.org/10.1063/1.4729301] C1 [Prokopenko, O. V.] Taras Shevchenko Natl Univ Kyiv, Fac Radiophys, UA-01601 Kiev, Ukraine. [Krivorotov, I. N.] Univ Calif Irvine, Dept Phys & Astron, Irvine, CA 92697 USA. [Bankowski, E.; Meitzler, T.] USA, TARDEC, Warren, MI 48397 USA. [Jaroch, S.; Tiberkevich, V. S.; Slavin, A. N.] Oakland Univ, Dept Phys, Rochester, MI 48309 USA. RP Prokopenko, OV (reprint author), Taras Shevchenko Natl Univ Kyiv, Fac Radiophys, UA-01601 Kiev, Ukraine. EM ovp@univ.kiev.ua RI Tiberkevich, Vasil/A-8697-2008 OI Tiberkevich, Vasil/0000-0002-8374-2565 FU U.S. Army TARDEC, RDECOM; National Science Foundation of the USA [ECCS-1001815, 1015175]; DARPA; State Agency of Science, Innovations and Informatization of Ukraine [M/212-2011]; State Fund for Fundamental Research of Ukraine [UU34/008] FX This work was supported in part by the Contract from the U.S. Army TARDEC, RDECOM, by the Grant Nos. ECCS-1001815 and DMR-1015175 from the National Science Foundation of the USA, by the grant from DARPA, by the Grant No. M/212-2011 from the State Agency of Science, Innovations and Informatization of Ukraine, and by the Grant No. UU34/008 from the State Fund for Fundamental Research of Ukraine. NR 12 TC 10 Z9 10 U1 4 U2 22 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD JUN 15 PY 2012 VL 111 IS 12 AR 123904 DI 10.1063/1.4729301 PG 6 WC Physics, Applied SC Physics GA 966IV UT WOS:000305832100078 ER PT J AU Williams, CL Ramesh, KT Dandekar, DP AF Williams, C. L. Ramesh, K. T. Dandekar, D. P. TI Spall response of 1100-O aluminum SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID FRACTURE; BEHAVIOR; DEFORMATION; SOLIDS; COPPER AB Plate impact experiments were conducted to study the effects of peak shock stress and pulse duration on the spall response of fully annealed 1100 aluminum. The spall strength was observed to decrease as the pulse duration was increased from approximately 0.58 mu s to 1.17 mu s. Also, an increase in tensile unloading strain rate increases the spall strength. However, our results also show an increase in spall strength with increase in peak shock stress up to approximately 8.3 GPa, followed by a decrease in spall strength for higher shock stresses. (C) 2012 American Institute of Physics. [http://dx.doi.org/10.1063/1.4729305] C1 [Williams, C. L.; Dandekar, D. P.] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. [Williams, C. L.; Ramesh, K. T.] Johns Hopkins Univ, Baltimore, MD 21218 USA. RP Williams, CL (reprint author), USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. FU United States Army Research Laboratory (ARL) at Aberdeen Proving Ground (APG); Center for Advanced Metallic and Ceramic Systems (CAMCS) at The Johns Hopkins University (JHU); Army Research Laboratory under ARMAC-RTP [W911NF-06-2-0006] FX This work was sponsored by both the United States Army Research Laboratory (ARL) at Aberdeen Proving Ground (APG) and the Center for Advanced Metallic and Ceramic Systems (CAMCS) at The Johns Hopkins University (JHU). Cyril Williams and Professor K. T. Ramesh also acknowledge support from the Army Research Laboratory under ARMAC-RTP Cooperative Agreement number W911NF-06-2-0006. The authors are grateful to Brian Schuster and Chris Meredith for supporting the Electron BackScatter Diffraction work, and also gratefully acknowledge the personnel at the Shock Physics Laboratory (Rich Becker, Stephan Bilyk, Tim Cline, and Codie Adams) for their technical contributions. NR 40 TC 12 Z9 13 U1 0 U2 9 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD JUN 15 PY 2012 VL 111 IS 12 AR 123528 DI 10.1063/1.4729305 PG 8 WC Physics, Applied SC Physics GA 966IV UT WOS:000305832100051 ER PT J AU Wolfenstine, J Ratchford, J Rangasamy, E Sakamoto, J Allen, JL AF Wolfenstine, Jeff Ratchford, Joshua Rangasamy, Ezhiyl Sakamoto, Jeffrey Allen, Jan L. TI Synthesis and high Li-ion conductivity of Ga-stabilized cubic Li7La3Zr2O12 SO MATERIALS CHEMISTRY AND PHYSICS LA English DT Article DE Garnet; Li; Ga; Cubic; Ionic conductivity; Hot-pressing ID SOLID-ELECTROLYTE; MIXED CONDUCTORS; METAL ANODE; GARNET; BATTERY; AL AB Ga addition to the garnet Li7La3Zr2O12 (LLZO) can lead to stabilization of the cubic structure, high relative density and high Li-ion conductivity at room temperature. Cubic Li6.25La3Zr2Ga0.25O12 powders were prepared from co-precipitated nitrate precursor and consolidated by hot-pressing to a relative density of similar to 91%. The total Li-ion conductivity was similar to 3.5 x 10(-4) Scm(-1) while the electronic conductivity was similar to 7.1 x 10(-8) Scm(-1). The Ga substituted LLZO had a slightly higher total Li-ion conductivity compared to Al substituted LLZO of similar composition and relative density. This difference may be related to the larger size of Ga versus Al leading to different site occupancy fractions. Published by Elsevier Ltd. C1 [Wolfenstine, Jeff; Ratchford, Joshua; Allen, Jan L.] USA, Res Lab, RDRL SED C, Adelphi, MD 20783 USA. [Rangasamy, Ezhiyl; Sakamoto, Jeffrey] Michigan State Univ, Dept Chem Engn & Mat Sci, E Lansing, MI 48824 USA. RP Wolfenstine, J (reprint author), USA, Res Lab, RDRL SED C, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM Jeffrey.b.wolfenstine.civ@mail.mil RI Rangasamy, Ezhiylmurugan/K-8340-2013 FU U.S. Army Research Laboratory (ARL); U.S. Army Research Office (ARO); United States Army Research Laboratory FX JW and JLA would like to acknowledge support of the U.S. Army Research Laboratory (ARL).; EL and JS authors would like to acknowledge the support of the U.S. Army Research Office (ARO). This research was performed while JBR held a National Research Council Research Associateship Award at the United States Army Research Laboratory. NR 23 TC 36 Z9 37 U1 10 U2 129 PU ELSEVIER SCIENCE SA PI LAUSANNE PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND SN 0254-0584 J9 MATER CHEM PHYS JI Mater. Chem. Phys. PD JUN 15 PY 2012 VL 134 IS 2-3 BP 571 EP 575 DI 10.1016/j.matchemphys.2012.03.054 PG 5 WC Materials Science, Multidisciplinary SC Materials Science GA 967OR UT WOS:000305918200004 ER PT J AU Walsh, MR Thiboutot, S Walsh, ME Ampleman, G AF Walsh, M. R. Thiboutot, S. Walsh, M. E. Ampleman, G. TI Controlled expedient disposal of excess gun propellant SO JOURNAL OF HAZARDOUS MATERIALS LA English DT Article DE Propellants; Burn pan; Lead; Disposal; Residues ID RANGES AB The expedient field disposal of excess gun propellants on the ground is an integral part of live-fire training in many countries. However, burning excess propellant in the field will leave significant quantities of energetic residues and heavy metals in the environment. Compounds such as dinitrotoluene and nitroglycerin and metals such as lead will leach into the soil column, eventually migrating to groundwater. Contamination of the environment will lead to high remediation costs and the possible loss of the training facility. After investigating the contamination at several propellant disposal sites, a portable propellant burn pan was developed and tested. The pan was transported to training sites where excess propellant was loaded and burned in a controlled manner. Up to 120 kg of excess single-base propellant charges have been burned during two series of tests at a consumption rate of greater than 99.9%. Less than 0.03% of the energetic material was recovered outside the burn pan. Recovered lead is largely contained within the pan. The turnover rate for burns is 15 min. The residues can be collected following cool-down for proper disposal. Published by Elsevier B.V. C1 [Walsh, M. R.; Walsh, M. E.] USA, Corps Engineers, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. [Thiboutot, S.; Ampleman, G.] Def Res & Dev Canada, DRDC Valcartier, Quebec City, PQ G3J 1X5, Canada. RP Walsh, MR (reprint author), USA, Corps Engineers, Cold Reg Res & Engn Lab, 72 Lyme Rd, Hanover, NH 03755 USA. EM Michael.Walsh@usace.army.mil FU U.S. Department of Defense; SERDP; [ER-1481] FX Funding for this project was granted by the U.S. Department of Defense Strategic Environmental Research and Development Program (SERDP), Dr. Jeff Marqusee, Director, under the Environmental Restoration program, Dr. Andrea Leeson, Director. Research and development work was performed under project ER-1481: Characterization and fate of gun and rocket propellant residues on testing and training ranges, Mr. Michael R. Walsh and Dr. Sonia Thiboutot, principle investigators. The sponsor, SERDP, approved the research plan and provided funding. Study design; collection, analysis, and interpretation of the data; writing of the report; and all publication decisions were the sole responsibilities of the principle investigators. NR 14 TC 0 Z9 0 U1 1 U2 14 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0304-3894 J9 J HAZARD MATER JI J. Hazard. Mater. PD JUN 15 PY 2012 VL 219 BP 89 EP 94 DI 10.1016/j.jhazmat.2012.03.060 PG 6 WC Engineering, Environmental; Engineering, Civil; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA 953SN UT WOS:000304893600012 PM 22503215 ER PT J AU Srikiatkhachorn, A Rothman, AL Gibbons, RV Sittisombut, N Malasit, P Ennis, FA Nimmannitya, S Kalayanarooj, S AF Srikiatkhachorn, Anon Rothman, Alan L. Gibbons, Robert V. Sittisombut, Nopporn Malasit, Prida Ennis, Francis A. Nimmannitya, Suchitra Kalayanarooj, Siripen TI Regarding "Dengue-How Best to Classify It" Reply SO CLINICAL INFECTIOUS DISEASES LA English DT Letter ID CASE CLASSIFICATION; MULTICENTER; COUNTRIES; SEVERITY C1 [Srikiatkhachorn, Anon] Univ Massachusetts, Sch Med, Dept Med, Worcester, MA 01655 USA. [Rothman, Alan L.] Univ Rhode Isl, Inst Immunol & Informat, Providence, RI 02908 USA. [Gibbons, Robert V.] Chiang Mai Univ, Armed Forces Res Inst Med Sci, Bangkok, Thailand. [Sittisombut, Nopporn] Chiang Mai Univ, Fac Med, Bangkok, Thailand. [Malasit, Prida] Mahidol Univ, Siriraj Hop, Bangkok 10700, Thailand. [Nimmannitya, Suchitra; Kalayanarooj, Siripen] Queen Sirikit Natl Inst Child Hlth, Bangkok, Thailand. RP Srikiatkhachorn, A (reprint author), Univ Massachusetts, Sch Med, Dept Med, 55 Lake Ave N,Rm S6-862, Worcester, MA 01655 USA. EM anon.srikiatkhachorn@umassmed.edu NR 11 TC 0 Z9 0 U1 0 U2 5 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 1058-4838 J9 CLIN INFECT DIS JI Clin. Infect. Dis. PD JUN 15 PY 2012 VL 54 IS 12 BP 1821 EP 1822 DI 10.1093/cid/cis344 PG 2 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 948YT UT WOS:000304541000034 ER PT J AU Kunz, AN Begum, AA Wu, H D'Ambrozio, JA Robinson, JM Shafer, WM Bash, MC Jerse, AE AF Kunz, Anjali N. Begum, Afrin A. Wu, Hong D'Ambrozio, Jonathan A. Robinson, James M. Shafer, William M. Bash, Margaret C. Jerse, Ann E. TI Impact of Fluoroquinolone Resistance Mutations on Gonococcal Fitness and In Vivo Selection for Compensatory Mutations SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article ID SEXUALLY-TRANSMITTED-DISEASES; GENITAL-TRACT INFECTION; MTRRCDE EFFLUX SYSTEM; NEISSERIA-GONORRHOEAE; ANTIBIOTIC-RESISTANCE; BIOLOGICAL COST; STAPHYLOCOCCUS-AUREUS; QUINOLONE RESISTANCE; TREATMENT GUIDELINES; SUSCEPTIBILITY AB Background. Quinolone-resistant Neisseria gonorrhoeae (QRNG) arise from mutations in gyrA (intermediate resistance) or gyrA and parC (resistance). Here we tested the consequence of commonly isolated gyrA(91/95) and parC(86) mutations on gonococcal fitness. Methods. Mutant gyrA(91/95) and parC(86) alleles were introduced into wild-type gonococci or an isogenic mutant that is resistant to macrolides due to an mtrR(-79) mutation. Wild-type and mutant bacteria were compared for growth in vitro and in competitive murine infection. Results. In vitro growth was reduced with increasing numbers of mutations. Interestingly, the gyrA(91/95) mutation conferred an in vivo fitness benefit to wild-type and mtrR(-79) mutant gonococci. The gyrA(91/95), parC(86) mutant, in contrast, showed a slight fitness defect in vivo, and the gyrA(91/95), parC(86), mtrR(-79) mutant was markedly less fit relative to the parent strains. A ciprofloxacin-resistant (Cip(R)) mutant was selected during infection with the gyrA(91/95), parC(86), mtrR(-79) mutant in which the mtrR(-79) mutation was repaired and the gyrA(91) mutation was altered. This in vivo-selected mutant grew as well as the wild-type strain in vitro. Conclusions. gyrA(91/95) mutations may contribute to the spread of QRNG. Further acquisition of a parC(86) mutation abrogates this fitness advantage; however, compensatory mutations can occur that restore in vivo fitness and maintain Cip(R). C1 [Kunz, Anjali N.; Begum, Afrin A.; Wu, Hong; D'Ambrozio, Jonathan A.; Robinson, James M.; Jerse, Ann E.] Uniformed Serv Univ Hlth Sci, Dept Microbiol & Immunol, Silver Spring, MD USA. [Kunz, Anjali N.] Walter Reed Army Inst Res, Mil HIV Res Program, Silver Spring, MD USA. [Shafer, William M.] Vet Affairs Med Ctr, VA Med Res Serv, Labs Microbial Pathogenesis, Decatur, GA 30033 USA. [Shafer, William M.] Emory Univ, Sch Med, Dept Microbiol & Immunol, Atlanta, GA 30322 USA. [Bash, Margaret C.] US FDA, Ctr Biol Evaluat & Res, Div Bacterial Allergen & Parasit Prod, Bethesda, MD USA. RP Jerse, AE (reprint author), Uniformed Serv Univ Hlth Sci, Dept Microbiol & Immunol, Bethesda, MD 20814 USA. EM ajerse@usuhs.mil FU National Institute of Allergy and Infectious Diseases at the National Institute of Health [RO1 AI42053, U19 AI31496, R37 AI21150]; Uniformed Services University of the Health Sciences [C073-RT]; VA Medical Research Service FX This work was supported by the National Institute of Allergy and Infectious Diseases at the National Institute of Health (RO1 AI42053 and U19 AI31496 to A. E. J.; R37 AI21150 to W. M. S.), and a Uniformed Services University of the Health Sciences training grant (C073-RT to A. N. K.). W. M. S. was supported in part by Senior Research Career Scientist and VA Merit awards from the VA Medical Research Service. NR 48 TC 33 Z9 34 U1 2 U2 6 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD JUN 15 PY 2012 VL 205 IS 12 BP 1821 EP 1829 DI 10.1093/infdis/jis277 PG 9 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 948YI UT WOS:000304539600010 PM 22492860 ER PT J AU Herrell, RK Bliese, PB Hoge, CW AF Herrell, R. K. Bliese, P. B. Hoge, C. W. TI COMBAT EXPERIENCES AND PTSD IN A MILITARY SAMPLE: RESULTS FROM A CLASSIFICATION BY EXPERT OPINION SO AMERICAN JOURNAL OF EPIDEMIOLOGY LA English DT Meeting Abstract CT 45th Annual Meeting of the Society-for-Epidemiologic-Research (SER) CY JUN 27-30, 2012 CL Minneapolis, MN SP Soc Epidemiol Res (SER) C1 [Herrell, R. K.; Bliese, P. B.; Hoge, C. W.] Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0002-9262 J9 AM J EPIDEMIOL JI Am. J. Epidemiol. PD JUN 15 PY 2012 VL 175 SU 11 BP S130 EP S130 PG 1 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 197ED UT WOS:000322831400514 ER PT J AU Wolfenstine, J Rangasamy, E Allen, JL Sakamoto, J AF Wolfenstine, Jeff Rangasamy, Ezhiyl Allen, Jan L. Sakamoto, Jeffrey TI High conductivity of dense tetragonal Li7La3Zr2O12 SO JOURNAL OF POWER SOURCES LA English DT Article DE Garnet; Tetragonal; Twins; Ionic conductivity; Hot-pressing ID LITHIUM ION CONDUCTION; SOLID-ELECTROLYTE; MIXED CONDUCTORS; STATE; MODEL; AL AB Hot-pressing at 1050 degrees C lead to near theoretical density (similar to 98% relative density) tetragonal LLZO. The total conductivity value for dense tetragonal LLZO is similar to 2.3 x 10(-5) S cm(-1). This is the highest reported value for tetragonal LLZO. This vast improvement in total conductivity is a result of the higher density achieved as a result of hot-pressing compared to conventional solid-state sintering. The value of the Li-ion lattice conductivity for dense tetragonal LLZO is 1.1 x 10(-4) S cm(-1). The microstructure of dense tetragonal LLZO consist of twins within the grains. It is suggested that the presence of twin boundaries adds a significant contribution to the total resistance. Published by Elsevier B.V. C1 [Wolfenstine, Jeff; Allen, Jan L.] USA, Res Lab, RDRL SED C, Adelphi, MD 20783 USA. [Rangasamy, Ezhiyl; Sakamoto, Jeffrey] Michigan State Univ, Dept Chem Engn & Mat Sci, E Lansing, MI 48824 USA. RP Wolfenstine, J (reprint author), USA, Res Lab, RDRL SED C, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM Jeffrey.b.wolfenstine.civ@mail.mil RI Rangasamy, Ezhiylmurugan/K-8340-2013 FU U.S. Army Research Laboratory (ARL); U.S. Army Research Office (ARO) FX JW and JAL would like to acknowledge support of the U.S. Army Research Laboratory (ARL). JS would like to acknowledge the support of the U.S. Army Research Office (ARO). NR 26 TC 43 Z9 43 U1 14 U2 175 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0378-7753 EI 1873-2755 J9 J POWER SOURCES JI J. Power Sources PD JUN 15 PY 2012 VL 208 BP 193 EP 196 DI 10.1016/j.jpowsour.2012.02.031 PG 4 WC Chemistry, Physical; Electrochemistry; Energy & Fuels; Materials Science, Multidisciplinary SC Chemistry; Electrochemistry; Energy & Fuels; Materials Science GA 932JE UT WOS:000303286500024 ER PT J AU Tian, JH Fuhrmann, SR Kluepfel-Stahl, S Carman, RJ Ellingsworth, L Flyer, DC AF Tian, Jing-Hui Fuhrmann, Steven R. Kluepfel-Stahl, Stefanie Carman, Robert J. Ellingsworth, Larry Flyer, David C. TI A novel fusion protein containing the receptor binding domains of C. difficile toxin A and toxin B elicits protective immunity against lethal toxin and spore challenge in preclinical efficacy models SO VACCINE LA English DT Article DE Clostridium difficile; Clostridium difficile associated disease; Vaccine; Toxin; Fusion protein ID CLOSTRIDIUM-DIFFICILE; INTRAVENOUS IMMUNOGLOBULIN; MONOCLONAL-ANTIBODIES; DIARRHEA; IMMUNIZATION; HAMSTERS; DISEASE; VACCINE; STRAIN; ASSOCIATION AB Antibodies targeting the Clostridium difficile toxin A and toxin B confer protective immunity to C. difficile associated disease in animal models and provided protection against recurrent C. difficile disease in human subjects. These antibodies are directed against the receptor binding domains (RBD) located in the carboxy-terminal portion of both toxins and inhibit binding of the toxins to their receptors. We have constructed a recombinant fusion protein containing portions of the RBD from both toxin A and toxin B and expressed it in Escherichia coli. The fusion protein induced high levels of serum antibodies to both toxins A and B capable of neutralizing toxin activity both in vitro and in vivo. In a hamster C. difficile infection model, immunization with the fusion protein reduced disease severity and conferred significant protection against a lethal dose of C. difficile spores. Our studies demonstrate the potential of the fusion protein as a vaccine that could provide protection from C. difficile disease in humans. (C) 2012 Elsevier Ltd. All rights reserved. C1 [Tian, Jing-Hui; Fuhrmann, Steven R.; Kluepfel-Stahl, Stefanie; Ellingsworth, Larry; Flyer, David C.] USA, Intercell, Gaithersburg, MD 20878 USA. [Carman, Robert J.] TechLab Inc, Blacksburg, VA USA. RP Flyer, DC (reprint author), Novavax Inc, Rockville, MD USA. EM dcflyer51@gmail.com NR 38 TC 31 Z9 31 U1 0 U2 3 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X J9 VACCINE JI Vaccine PD JUN 13 PY 2012 VL 30 IS 28 BP 4249 EP 4258 DI 10.1016/j.vaccine.2012.04.045 PG 10 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 965PT UT WOS:000305780400017 PM 22537987 ER PT J AU Salje, H Lessler, J Endy, TP Curriero, FC Gibbons, RV Nisalak, A Nimmannitya, S Kalayanarooj, S Jarman, RG Thomas, SJ Burke, DS Cummings, DAT AF Salje, Henrik Lessler, Justin Endy, Timothy P. Curriero, Frank C. Gibbons, Robert V. Nisalak, Ananda Nimmannitya, Suchitra Kalayanarooj, Siripen Jarman, Richard G. Thomas, Stephen J. Burke, Donald S. Cummings, Derek A. T. TI Revealing the microscale spatial signature of dengue transmission and immunity in an urban population SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA LA English DT Article DE dynamics; spatial statistics; dengue hemorrhagic fever ID POINT PATTERN-ANALYSIS; HEMORRHAGIC-FEVER; HERD-IMMUNITY; UNITED-STATES; K-FUNCTION; EPIDEMIOLOGY; BANGKOK; DISEASE; HOST AB It is well-known that the distribution of immunity in a population dictates the future incidence of infectious disease, but this process is generally understood at individual or macroscales. For example, herd immunity to multiple pathogens has been observed at national and city levels. However, the effects of population immunity have not previously been shown at scales smaller than the city (e.g., neighborhoods). In particular, no study has shown long-term effects of population immunity at scales consistent with the spatial scale of person-to-person transmission. Here, we use the location of dengue patients' homes in Bangkok with the serotype of the infecting pathogen to investigate the spatiotemporal distribution of disease risk at small spatial scales over a 5-y period. We find evidence for localized transmission at distances of under 1 km. We also observe patterns of spatiotemporal dependence consistent with the expected impacts of homotypic immunity, heterotypic immunity, and immune enhancement of disease at these distances. Our observations indicate that immunological memory of dengue serotypes occurs at the neighborhood level in this large urban setting. These methods have broad applications to studying the spatiotemporal structure of disease risk where pathogen serotype or genetic information is known. C1 [Salje, Henrik; Lessler, Justin; Cummings, Derek A. T.] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD 21205 USA. [Curriero, Frank C.] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Environm Hlth Sci, Baltimore, MD 21205 USA. [Endy, Timothy P.] Upstate Med Univ, SUNY, Dept Med, Syracuse, NY 13210 USA. [Gibbons, Robert V.; Nisalak, Ananda] Armed Forces Res Inst Med Sci, Dept Virol, Bangkok 10400, Thailand. [Nimmannitya, Suchitra; Kalayanarooj, Siripen] Queen Sirikit Natl Inst Child Hlth, Bangkok 10400, Thailand. [Jarman, Richard G.; Thomas, Stephen J.] Walter Reed Army Inst Res, Viral Dis Branch, Silver Spring, MD 20910 USA. [Burke, Donald S.] Univ Pittsburgh, Grad Sch Publ Hlth, Pittsburgh, PA 15261 USA. RP Cummings, DAT (reprint author), Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD 21205 USA. EM dcumming@jhsph.edu OI Lessler, Justin/0000-0002-9741-8109; /0000-0002-5704-8094; Salje, Henrik/0000-0003-3626-4254 FU Gates Foundation Vaccine Modeling Initiative; National Institutes of Health (NIH) [1U54GM088491-0109, R01GM090204]; Burroughs Wellcome Fund Career Award at the Scientific Interface; Research and Policy for Infectious Disease Dynamics (RAPIDD) initiative of the NIH; Department of Homeland Security FX J.L., D.S.B., and D.A.T.C. received support from the Gates Foundation Vaccine Modeling Initiative and National Institutes of Health (NIH) Grant 1U54GM088491-0109. D.A.T.C. also received support from NIH Grant R01GM090204, the Burroughs Wellcome Fund Career Award at the Scientific Interface, and the Research and Policy for Infectious Disease Dynamics (RAPIDD) initiative of the NIH and Department of Homeland Security. NR 25 TC 46 Z9 46 U1 2 U2 13 PU NATL ACAD SCIENCES PI WASHINGTON PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA SN 0027-8424 J9 P NATL ACAD SCI USA JI Proc. Natl. Acad. Sci. U. S. A. PD JUN 12 PY 2012 VL 109 IS 24 BP 9535 EP 9538 DI 10.1073/pnas.1120621109 PG 4 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 962AL UT WOS:000305511300067 PM 22645364 ER PT J AU Myneni, K Smith, DD Odutola, JA Schambeau, CA AF Myneni, Krishna Smith, David D. Odutola, Jamiu A. Schambeau, Charles A. TI Tuning the scale factor and sensitivity of a passive cavity with optical pumping SO PHYSICAL REVIEW A LA English DT Article AB The pushing of the Fabry-Perot cavity modes by an intracavity medium of Rb vapor may be tuned with optical pumping. A second laser, propagating through the Rb vapor orthogonal to the intracavity beam, is used to modify the optical transmission of the Rb vapor. We demonstrate that the cavity scale factor may be switched from S > 1, on one side of its pole along the gain axis, to the other side of the pole, where mode splitting occurs, simply by changing the pumping transition. Continuous tuning of the cavity scale factor and sensitivity may be realized by varying the intensity and/or frequency of the pump beam. C1 [Myneni, Krishna] USA, RDMR WSS, Res Dev & Engn Command, Redstone Arsenal, AL 35898 USA. [Smith, David D.] NASA, George C Marshall Space Flight Ctr, Spacecraft & Vehicle Syst Dept, Huntsville, AL 35812 USA. [Odutola, Jamiu A.] Alabama A&M Univ, Dept Nat & Phys Sci Chem, Normal, AL 35762 USA. [Schambeau, Charles A.] Univ Alabama, Dept Phys, Huntsville, AL 35899 USA. RP Myneni, K (reprint author), USA, RDMR WSS, Res Dev & Engn Command, Redstone Arsenal, AL 35898 USA. EM krishna.myneni@us.army.mil NR 17 TC 6 Z9 6 U1 0 U2 3 PU AMER PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 2469-9926 EI 2469-9934 J9 PHYS REV A JI Phys. Rev. A PD JUN 11 PY 2012 VL 85 IS 6 AR 063813 DI 10.1103/PhysRevA.85.063813 PG 10 WC Optics; Physics, Atomic, Molecular & Chemical SC Optics; Physics GA 956KG UT WOS:000305087900012 ER PT J AU Allon, N Saxena, A Chambers, C Doctor, BP AF Allon, Nahum Saxena, Ashima Chambers, Carolyn Doctor, Bhupendra P. TI A new liposome-based gene delivery system targeting lung epithelial cells using endothelin antagonist SO JOURNAL OF CONTROLLED RELEASE LA English DT Article DE DNA encapsulation; Endothelin receptor; Green fluorescent protein; Intra-tracheal instillation; Liposomes; Targeted gene delivery system ID C-TERMINAL HEXAPEPTIDE; NONVIRAL DELIVERY; FUSION GENES; RECEPTOR; INTERNALIZATION; PHOSPHATIDYLSERINE; THERAPY; DESIGN; CANCER; HOMEOSTASIS AB We formulated a new gene delivery system based on targeted liposomes. The efficacy of the delivery system was demonstrated in in vitro and in vivo models. The targeting moiety consists of a high-affinity 7-aminoacid peptide, covalently and evenly conjugated to the liposome surface. The targeting peptide acts as an endothelin antagonist, and accelerates liposome binding and internalization. It is devoid of other biological activity. Liposomes with high phosphatidyl serine (PS) were specially formulated to help their fusion with the endosomal membrane at low pH and enable release of the liposome payload into the cytoplasm. A DNA payload, pre-compressed by protamine, was encapsulated into the liposomes, which directed the plasmid into the cell's nucleus. Upon exposure to epithelial cells, binding of the liposomes occurred within 510 min, followed by facilitated internalization of the complex. Endosomal escape was complete within 30 min, followed by DNA accumulation in the nucleus 2 h post-transfection. A549 lung epithelial cells transfected with plasmid encoding for GFP encapsulated in targeted liposomes expressed significantly more protein than those transfected with plasmid complexed with Lipofectamine. The intra-tracheal instillation of plasmid encoding for GFP encapsulated in targeted liposomes into rat lungs resulted in the expression of GFP in bronchioles and alveoli within 5 days. These results suggest that this delivery system has great potential in targeting genes to lungs. (C) 2011 Elsevier B. V. All rights reserved. C1 [Allon, Nahum; Saxena, Ashima; Chambers, Carolyn; Doctor, Bhupendra P.] Walter Reed Army Inst Res, Div Biochem, Silver Spring, MD 20910 USA. RP Allon, N (reprint author), Israel Inst Biol Res, Dept Pharmacol, 24 Reuven St, IL-74100 Ness Ziona, Israel. EM allon_nahum@hotmail.com FU Defense Threat Reduction Agency FX The opinions or assertions contained herein are the private views of the authors, and are not to be construed as official, or as reflecting true views of the Department of the Army or the Department of Defense. The authors wish to thank Ms. Amy Michels for her assistance in the preparation of the manuscript. Funding for this project was provided by the Defense Threat Reduction Agency. NR 42 TC 14 Z9 15 U1 3 U2 16 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0168-3659 J9 J CONTROL RELEASE JI J. Control. Release PD JUN 10 PY 2012 VL 160 IS 2 BP 217 EP 224 DI 10.1016/j.jconrel.2011.10.033 PG 8 WC Chemistry, Multidisciplinary; Pharmacology & Pharmacy SC Chemistry; Pharmacology & Pharmacy GA 965SY UT WOS:000305788800013 PM 22079949 ER PT J AU Crawford, DC DeBerardino, TM Williams, RJ AF Crawford, Dennis C. DeBerardino, Thomas M. Williams, Riley J., III TI NeoCart, an Autologous Cartilage Tissue Implant, Compared with Microfracture for Treatment of Distal Femoral Cartilage Lesions An FDA Phase-II Prospective, Randomized Clinical Trial After Two Years SO JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME LA English DT Article ID CHONDROCYTE IMPLANTATION; CHONDRAL DEFECTS; KNEE; OSTEOARTHRITIS; OUTCOMES; REPAIR; TRANSPLANTATION; EFFICACY AB Background: Despite introduction of autologous chondrocyte therapy for repair of hyaline articular cartilage injury in 1994, microfracture remains a primary standard of care. NeoCart, an autologous cartilage tissue implant, was compared with microfracture in a multisite prospective, randomized trial of a tissue-engineered bioimplant for treating articular cartilage injuries in the knee. Methods: Thirty patients were randomized at a ratio of two to one (two were treated with an autologous cartilage tissue implant [NeoCart] for each patient treated with microfracture) at the time of arthroscopic confirmation of an International Cartilage Repair Society (ICRS) grade-III lesion(s). Microfracture or cartilage biopsy was performed. NeoCart, produced by seeding a type-I collagen matrix scaffold with autogenous chondrocytes and bioreactor treatment, was implanted six weeks following arthroscopic cartilage biopsy. Standard evaluations were performed with validated clinical outcomes measures. Results: Three, six, twelve, and twenty-four-month data are reported. The mean duration of follow-up (and standard deviation) was 26 +/- 2 months. There were twenty-one patients in the NeoCart group and nine in the microfracture group. The mean age (40 +/- 9 years), body mass index (BMI) (28 +/- 4 kg/m(2)), duration between the first symptoms and treatment (3 +/- 5 years), and lesion size (287 +/- 138 mm(2) in the NeoCart group and 252 +/- 135 mm(2) in the microfracture group) were similar between the groups. Adverse event rates per procedure did not differ between the treatment arms. The scores on the Short Form-36 (SF-36), Knee Injury and Osteoarthritis Outcome Score (KOOS) activities of daily living (ADL) scale, and International Knee Documentation Committee (IKDC) form improved from baseline (p < 0.05) to two years postoperatively in both treatment groups. In the NeoCart group, improvement, compared with baseline, was significant (p < 0.05) for all measures at six, twelve, and twenty-four months. Improvement in the NeoCart group was significantly greater (p < 0.05) than that in the microfracture group for the KOOS pain score at six, twelve, and twenty-four months; the KOOS symptom score at six months; the IKDC, KOOS sports, and visual analog scale (VAS) pain scores at twelve and twenty-four months; and the KOOS quality of life (QOL) score at twenty-four months. Analysis of covariance (ANCOVA) at one year indicated that the change in the KOOS pain (p = 0.016) and IKDC (p = 0.028) scores from pretreatment levels favored the NeoCart group. Significantly more NeoCart-treated patients (p = 0.0125) had responded to therapy (were therapeutic responders) at six months (43% versus 25% in the microfracture group) and twelve months (76% versus 22% in the microfracture group). This trend continued, as the proportion of NeoCart-treated patients (fifteen of nineteen) who were therapeutic responders at twenty-four months was greater than the proportion of microfracture-treated participants (four of nine) who were therapeutic responders at that time. Conclusions: This randomized study suggests that the safety of autologous cartilage tissue implantation, with use of the NeoCart technique, is similar to that of microfracture surgery and is associated with greater clinical efficacy at two years after treatment. C1 Oregon Hlth & Sci Ctr, Portland, OR USA. Keller Army Community Hosp, West Point, NY USA. Duke Sports Med Ctr, Durham, NC USA. Univ Calif San Francisco, San Francisco, CA 94143 USA. TRIA Orthopaed Ctr, Bloomington, MN USA. Hosp Special Surg, New York, NY 10021 USA. RP Crawford, DC (reprint author), Oregon Hlth & Sci Univ, Dept Orthopaed & Rehabil, 3181 SW Sam Jackson Pk Rd,Mail Code OP31, Portland, OR 97239 USA. EM crawfden@ohsu.edu OI DeBerardino, Thomas/0000-0002-7110-8743 NR 46 TC 55 Z9 59 U1 3 U2 32 PU JOURNAL BONE JOINT SURGERY PI NEEDHAM PA 20 PICKERING ST, NEEDHAM, MA 02492 USA SN 0021-9355 EI 1535-1386 J9 J BONE JOINT SURG AM JI J. Bone Joint Surg.-Am. Vol. PD JUN 6 PY 2012 VL 94A IS 11 BP 979 EP 989 DI 10.2106/JBJS.K.00533 PG 11 WC Orthopedics; Surgery SC Orthopedics; Surgery GA 954WC UT WOS:000304977700003 PM 22637204 ER PT J AU Powell, C Schawbel, D AF Powell, Colin Schawbel, Dan TI Battle Ready SO FORBES LA English DT Editorial Material AB Advice for startups from a seasoned veteran. C1 [Powell, Colin] USA, Washington, DC USA. [Schawbel, Dan] Millennial Branding, Boston, MA USA. [Schawbel, Dan] Forbes Com, New York, NY USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU FORBES INC PI NEW YORK PA 60 FIFTH AVE, NEW YORK, NY 10011 USA SN 0015-6914 J9 FORBES JI Forbes PD JUN 4 PY 2012 VL 189 IS 10 BP 50 EP 50 PG 1 WC Business, Finance SC Business & Economics GA 944XN UT WOS:000304237200010 ER PT J AU Schmaljohn, C Mandl, CW AF Schmaljohn, Connie Mandl, Christian W. TI The interface of animal and human vaccines SO CURRENT OPINION IN VIROLOGY LA English DT Editorial Material ID ERADICATION; SMALLPOX C1 [Schmaljohn, Connie] USA, Med Res Inst Infect Dis, Frederick, MD 21702 USA. [Mandl, Christian W.] Novartis Vaccines & Diagnost Inc, Cambridge, MA 02139 USA. RP Schmaljohn, C (reprint author), USA, Med Res Inst Infect Dis, Frederick, MD 21702 USA. EM connie.schmaljohn@us.army.mil; christian.mandl@novartis.com NR 8 TC 1 Z9 1 U1 0 U2 2 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1879-6257 J9 CURR OPIN VIROL JI Curr. Opin. Virol. PD JUN PY 2012 VL 2 IS 3 BP 306 EP 308 DI 10.1016/j.coviro.2012.04.001 PG 3 WC Virology SC Virology GA 051FY UT WOS:000312112800012 PM 22542098 ER PT J AU Dupuy, LC Reed, DS AF Dupuy, Lesley C. Reed, Douglas S. TI Nonhuman primate models of encephalitic alphavirus infection: historical review and future perspectives SO CURRENT OPINION IN VIROLOGY LA English DT Article ID VENEZUELAN EQUINE ENCEPHALITIS; MACACA-RHESUS MONKEYS; CYNOMOLGUS MACAQUES; ENCEPHALOMYELITIS VIRUS; AEROSOL CHALLENGE; ANIMAL-MODELS; NEUTRALIZING ANTIBODIES; ATTENUATED VACCINES; RESPIRATORY TRACT; OLFACTORY ROUTE AB Venezuelan, western, and eastern equine encephalitis viruses are New World alphaviruses that are recognized as potential agents of biowarfare and bioterrorism owing to their morbidity and mortality in humans, ease of production, considerable stability, and high infectivity in aerosols. As a result, these encephalitic alphaviruses are defined as category B select agents. Studies involving infection of nonhuman primates have been instrumental in gaining an understanding of the in vivo pathogenesis of these viruses and have provided relevant models to evaluate the efficacy of candidate human vaccines. Recent advances have led to refinement and further characterization of these models toward the goal of utility in the licensure of next-generation alphavirus vaccines and therapeutics for use in humans by the Animal Rule. C1 [Reed, Douglas S.] Univ Pittsburgh, Ctr Vaccine Res, Pittsburgh, PA 15261 USA. [Dupuy, Lesley C.] USA, Div Virol, Med Res Inst Infect Dis, Frederick, MD 21702 USA. RP Reed, DS (reprint author), Univ Pittsburgh, Ctr Vaccine Res, Pittsburgh, PA 15261 USA. EM dsreed@cvr.pitt.edu OI Reed, Douglas/0000-0003-0076-9023 NR 32 TC 2 Z9 2 U1 0 U2 10 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1879-6257 J9 CURR OPIN VIROL JI Curr. Opin. Virol. PD JUN PY 2012 VL 2 IS 3 BP 363 EP 367 DI 10.1016/j.coviro.2012.02.014 PG 5 WC Virology SC Virology GA 051FY UT WOS:000312112800021 PM 22709522 ER PT J AU Koukoulopoulos, D Thiel, J AF Koukoulopoulos, Dimitris Thiel, Johann TI Arrangements of Stars on the American Flag SO AMERICAN MATHEMATICAL MONTHLY LA English DT Article AB In this article, we examine the existence of nice arrangements of stars on the American flag. We show that despite the existence of such arrangements for any number of stars from 1 to 100, with the exception of 29, 69 and 87, they are rare as the number of stars increases. C1 [Koukoulopoulos, Dimitris] Univ Montreal, Ctr Rech Math, Ctr Ville Stn, Montreal, PQ H3C 3J7, Canada. [Thiel, Johann] US Mil Acad, Dept Math Sci, West Point, NY 10996 USA. RP Koukoulopoulos, D (reprint author), Univ Montreal, Ctr Rech Math, Ctr Ville Stn, POB 6128, Montreal, PQ H3C 3J7, Canada. EM koukoulo@crm.umontreal.ca; johann.thiel@usma.edu NR 9 TC 1 Z9 1 U1 0 U2 0 PU MATHEMATICAL ASSOC AMER PI WASHINGTON PA 1529 18TH STREET NW, WASHINGTON, DC 20036 USA SN 0002-9890 J9 AM MATH MON JI Am. Math. Mon. PD JUN-JUL PY 2012 VL 119 IS 6 BP 443 EP 450 DI 10.4169/amer.math.monthly.119.06.443 PG 8 WC Mathematics SC Mathematics GA 028AP UT WOS:000310395500001 ER PT J AU Atkins, AR AF Atkins, Andrew R. TI DOCTRINALLY ACCOUNTING FOR HOST NATION SOVEREIGNTY DURING U.S. COUNTERINSURGENCY SECURITY OPERATIONS SO MILITARY LAW REVIEW LA English DT Article ID WAR C1 USA, Washington, DC 20310 USA. RP Atkins, AR (reprint author), USA, Washington, DC 20310 USA. NR 117 TC 0 Z9 0 U1 0 U2 0 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 USA SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD SUM PY 2012 VL 212 BP 70 EP 132 PG 63 WC Law SC Government & Law GA 022HN UT WOS:000309948800002 ER PT J AU Warren, B AF Warren, Brittany TI THE CASE OF THE MURDERING WIVES: REID V. COVERT AND THE COMPLICATED QUESTION OF CIVILIANS AND COURTS-MARTIAL SO MILITARY LAW REVIEW LA English DT Article ID ARMED-FORCES; MILITARY; JURISDICTION; ABROAD; LAW C1 USA, Washington, DC 20310 USA. RP Warren, B (reprint author), USA, Washington, DC 20310 USA. NR 117 TC 2 Z9 2 U1 0 U2 0 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 USA SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD SUM PY 2012 VL 212 BP 133 EP 193 PG 61 WC Law SC Government & Law GA 022HN UT WOS:000309948800003 ER PT J AU Lamont, TR AF Lamont, Thomas. R. TI THE THIRTIETH CHARLES L. DECKER LECTURE IN ADMINISTRATIVE AND CIVIL LAW SO MILITARY LAW REVIEW LA English DT Article C1 USA, Washington, DC 20310 USA. RP Lamont, TR (reprint author), USA, Washington, DC 20310 USA. NR 1 TC 0 Z9 0 U1 0 U2 1 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 USA SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD SUM PY 2012 VL 212 BP 222 EP 230 PG 9 WC Law SC Government & Law GA 022HN UT WOS:000309948800005 ER PT J AU Kurz, M AF Kurz, Margaret TI IN THE GARDEN OF BEASTS, LOVE, TERROR, AND AN AMERICAN FAMILY IN HITLER'S BERLIN SO MILITARY LAW REVIEW LA English DT Book Review C1 [Kurz, Margaret] USA, Washington, DC 20310 USA. RP Kurz, M (reprint author), USA, Washington, DC 20310 USA. NR 7 TC 0 Z9 0 U1 0 U2 0 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 USA SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD SUM PY 2012 VL 212 BP 261 EP 269 PG 9 WC Law SC Government & Law GA 022HN UT WOS:000309948800008 ER PT J AU Lafortune, KA Dichristina, WD AF Lafortune, Kathryn A. Dichristina, Wendy Dunne TI Representing Clients with Mental Disabilities in Custody Hearings: Using the ADA to Help in a Best-Interests-of-the-Child Determination SO FAMILY LAW QUARTERLY LA English DT Article C1 [Lafortune, Kathryn A.] Oklahoma Indigent Def Syst, Psychol Serv, Oklahoma City, OK USA. [Lafortune, Kathryn A.] Univ Tulsa, Coll Law, Tulsa, OK 74104 USA. [Lafortune, Kathryn A.] New York Law Sch, New York, NY USA. [Lafortune, Kathryn A.] Univ Tulsa, Dept Psychol, Tulsa, OK 74104 USA. [Lafortune, Kathryn A.] Oklahoma State Univ, Coll Hlth Sci, Coll Osteopath Med, Stillwater, OK 74078 USA. [Dichristina, Wendy Dunne] USA, Washington, DC USA. RP Lafortune, KA (reprint author), Oklahoma Indigent Def Syst, Psychol Serv, Oklahoma City, OK USA. NR 17 TC 1 Z9 1 U1 0 U2 0 PU AMER BAR ASSOC, ADMINISTRATIVE LAW & REGULATORY PRACTICE SECTION PI CHICAGO PA 321 N CLARK ST, CHICAGO, IL 60610 USA SN 0014-729X J9 FAM LAW QUART JI Fam. Law Q. PD SUM PY 2012 VL 46 IS 2 BP 223 EP 246 PG 24 WC Family Studies; Law SC Family Studies; Government & Law GA 020ZA UT WOS:000309853900003 ER PT J AU Gaston, JR Letowski, TR AF Gaston, Jeremy R. Letowski, Tomasz R. TI Listener perception of single-shot small arms fire SO NOISE CONTROL ENGINEERING JOURNAL LA English DT Article ID SOUNDS; CATEGORIZATION; FREQUENCY AB The ability to identify and interpret impulse sounds from small arms weapons fire is a very important element of a soldier's situational awareness that is critically needed to avoid potential danger. For example, differentiation of hostile from friendly weapons fire can indicate the need for increased vigilance and can reveal the approximate location of an enemy element. In addition, estimation of weapon size can be used to infer the resources of an enemy element. Despite the potential operational importance of these sounds, little is known about listener perception of impulse weapons sounds. The present work investigates listener ability to differentiate signatures of various small arms weapons on the basis of high-quality recordings of single-shot impulse sounds. Experiment 1 measured listener perceived similarity for paired small arms impulse sounds. A multidimensional scaling solution (MDS) based on listener ratings showed significant overlap in perceptual space for most rifle sounds, but the mappings of handgun sounds were largely segregated from all rifle sounds. These mappings correlated well with measured source and sound properties of the small arms weapons. Experiment 2 measured discrimination performance for selected sets of contrasted weapon pairings. In general, discrimination performance correlated well with the listener perceptual space measured in Experiment 1, with best performance for handgun-rifle pairings and worst performance for rifle-rifle pairings. (c) 2012 Institute of Noise Control Engineering. C1 [Gaston, Jeremy R.; Letowski, Tomasz R.] USA, Army Res Lab, Dept Army, RDRL HRS D, Aberdeen Proving Ground, MD 21005 USA. RP Gaston, JR (reprint author), USA, Army Res Lab, Dept Army, RDRL HRS D, Aberdeen Proving Ground, MD 21005 USA. EM jeremy.r.gaston.civ@.mail.mil; tomasz.r.letowski.civ@mail.mil FU US Army Research Laboratory Postdoctoral Fellowship program FX This research was supported in part by an appointment to the US Army Research Laboratory Postdoctoral Fellowship program administered by Oakridge Affiliated Universities through a contract with the US Army Research Laboratory. The authors would like to thank Kim Fluitt, Paula Henry and Timothy Mermagen, for their thoughtful suggestions and technical assistance in the conduct of this research. NR 25 TC 3 Z9 3 U1 0 U2 5 PU INST NOISE CONTROL ENGINEERING PI AMES PA IOWA STATE UNIV, COLLEGE ENGINEERING, 212 MARSTON HALL, AMES, IA 50011-2152 USA SN 0736-2501 J9 NOISE CONTROL ENG J JI Noise Control Eng. J. PD JUN PY 2012 VL 60 IS 3 BP 236 EP 245 PG 10 WC Acoustics; Engineering, Multidisciplinary SC Acoustics; Engineering GA 014YC UT WOS:000309410800002 ER PT J AU Hale, DF Clifton, GT Sears, AK Vreeland, TJ Shumway, N Peoples, GE Mittendorf, EA AF Hale, Diane F. Clifton, G. Travis Sears, Alan K. Vreeland, Timothy J. Shumway, Nathan Peoples, George E. Mittendorf, Elizabeth A. TI Cancer vaccines: should we be targeting patients with less aggressive disease? SO EXPERT REVIEW OF VACCINES LA English DT Review DE biologic factors; cancer vaccines; clinical trials; early-stage disease; immunotherapy; metastatic disease ID TUMOR-INFILTRATING LYMPHOCYTES; ACTIVE SPECIFIC IMMUNOTHERAPY; REGULATORY T-CELLS; GROUP-STUDY I-01; HLA CLASS-I; TRANSCRIPTION FACTOR FOXP3; HER2/NEU PEPTIDE VACCINE; GROWTH-FACTOR-BETA; III COLON-CANCER; BREAST-CANCER AB There is enthusiasm for using vaccines to stimulate the immune system to treat cancer. In this article, the authors review the evolution of vaccines evaluated in clinical trials, starting with Phase III trials in metastatic disease and progressing to trials in the adjuvant setting. Data from these trials suggest that cancer vaccines may be more effective in patients with lower volume disease, and data from the E75 peptide vaccine trials suggest that vaccines may be most effective in less aggressive disease. C1 [Mittendorf, Elizabeth A.] Univ Texas MD Anderson Canc Ctr, Dept Surg Oncol, Houston, TX 77030 USA. [Hale, Diane F.; Clifton, G. Travis; Sears, Alan K.; Vreeland, Timothy J.; Peoples, George E.] Brooke Army Med Ctr, Dept Surg, Gen Surg Serv, San Antonio, TX USA. [Shumway, Nathan] Brooke Army Med Ctr, Dept Med, Hematol Oncol Serv, San Antonio, TX USA. RP Mittendorf, EA (reprint author), Univ Texas MD Anderson Canc Ctr, Dept Surg Oncol, Houston, TX 77030 USA. EM eamitten@mdanderson.org NR 88 TC 16 Z9 17 U1 0 U2 4 PU EXPERT REVIEWS PI LONDON PA UNITEC HOUSE, 3RD FL, 2 ALBERT PLACE, FINCHLEY CENTRAL, LONDON N3 1QB, ENGLAND SN 1476-0584 EI 1744-8395 J9 EXPERT REV VACCINES JI Expert Rev. Vaccines PD JUN PY 2012 VL 11 IS 6 BP 721 EP 731 DI 10.1586/ERV.12.39 PG 11 WC Immunology SC Immunology GA 007OK UT WOS:000308897800012 PM 22873128 ER PT J AU Alving, CR Rao, M Steers, NJ Matyas, GR Mayorov, AV AF Alving, Carl R. Rao, Mangala Steers, Nicholas J. Matyas, Gary R. Mayorov, Alexander V. TI Liposomes containing lipid A: an effective, safe, generic adjuvant system for synthetic vaccines SO EXPERT REVIEW OF VACCINES LA English DT Review DE adjuvant; adjuvant mechanisms; adjuvant systems; data mining; lipid A; liposomes; monophosphoryl lipid A; patents and intellectual property; peptide vaccines ID T-CELL RESPONSES; PROTEASOME ACTIVATOR PA28; RECEPTOR 4 AGONIST; MALARIA VACCINE; DENDRITIC CELLS; ESCHERICHIA-COLI; BIOLOGICAL-ACTIVITIES; ANTIGEN PRESENTATION; ANTIBODY-RESPONSES; PEPTIDE ANTIGENS AB Liposomes containing monophosphoryl lipid A (MPLA) have previously exhibited considerable potency and safety in human trials with a variety of candidate vaccines, including vaccines to malaria, HIV-1 and several different types of cancer. The long history of research and development of MPLA and liposomal MPLA as vaccine adjuvants reveals that there are numerous opportunities for creation and development of generic (nonproprietary) adjuvant system formulations with these materials that are not only highly potent and safe, but also readily available as native materials or as synthetic compounds. They are easily manufactured as potentially inexpensive and easy to use adjuvant systems and might be effective even with synthetic peptides as antigens. C1 [Alving, Carl R.; Rao, Mangala; Steers, Nicholas J.; Matyas, Gary R.; Mayorov, Alexander V.] Walter Reed Army Inst Res, Lab Adjuvant & Antigen Res, US Mil HIV Res Program, Silver Spring, MD 20910 USA. RP Alving, CR (reprint author), Walter Reed Army Inst Res, Lab Adjuvant & Antigen Res, US Mil HIV Res Program, Silver Spring, MD 20910 USA. EM calving@hivresearch.org RI Mayorov, Alexander/G-5204-2014; OI Mayorov, Alexander/0000-0002-0899-7138; Matyas, Gary/0000-0002-2074-2373 FU Henry M Jackson Foundation for the Advancement of Military Medicine [W81XWH-07-2-067]; US Army Medical Research and Materiel Command [W81XWH-07-2-067] FX This work was supported through a Cooperative Agreement contract (No. W81XWH-07-2-067) between the Henry M Jackson Foundation for the Advancement of Military Medicine and the US Army Medical Research and Materiel Command. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. NR 107 TC 36 Z9 37 U1 1 U2 17 PU EXPERT REVIEWS PI LONDON PA UNITEC HOUSE, 3RD FL, 2 ALBERT PLACE, FINCHLEY CENTRAL, LONDON N3 1QB, ENGLAND SN 1476-0584 J9 EXPERT REV VACCINES JI Expert Rev. Vaccines PD JUN PY 2012 VL 11 IS 6 BP 733 EP 744 DI 10.1586/ERV.12.35 PG 12 WC Immunology SC Immunology GA 007OK UT WOS:000308897800013 PM 22873129 ER PT J AU Brossy, CC Kelson, KI Amos, CB Baldwin, JN Kozlowicz, B Simpson, D Ticci, MG Lutz, AT Kozaci, O Streig, A Turner, R Rose, R AF Brossy, C. C. Kelson, K. I. Amos, C. B. Baldwin, J. N. Kozlowicz, B. Simpson, D. Ticci, M. G. Lutz, A. T. Kozaci, O. Streig, A. Turner, R. Rose, R. TI Map of the late Quaternary active Kern Canyon and Breckenridge faults, southern Sierra Nevada, California SO GEOSPHERE LA English DT Article ID EASTERN CALIFORNIA; MOJAVE-DESERT; TULARE-COUNTY; SHEAR ZONE; SLIP RATE; SYSTEM; TECTONICS; EVOLUTION; LITHOSPHERE; BATHOLITH AB Surface traces of the Quaternary active Kern Canyon and Breckenridge faults were mapped via aerial reconnaissance, analysis of light detection and ranging (LiDAR) elevation data, review and interpretation of aerial photography, field reconnaissance, and detailed field mapping. This effort specifically targeted evidence of late Quaternary surface deformation and, combined with separate paleoseismic investigations, identified and characterized the North Kern Canyon, South Kern Canyon, and Lake Isabella sections of the Kern Canyon fault and the Breckenridge fault. The mapping presented here provides definitive evidence for previously unrecognized Holocene and late Pleistocene east-down displacement along the Kern Canyon and Breckenridge faults. Our results indicate that much of the Kern Canyon fault has undergone Quaternary reactivation to accommodate internal deformation of the otherwise rigid Sierra Nevada block. This deformation reflects ongoing, seismogenic crustal thinning in the southern Sierra Nevada, and highlights the effects of localized tectonic forces operating in this part of the Sierra Nevada. C1 [Brossy, C. C.; Kelson, K. I.; Baldwin, J. N.; Ticci, M. G.; Lutz, A. T.; Kozaci, O.; Turner, R.] Fugro Consultants Inc, Walnut Creek, CA 94596 USA. [Amos, C. B.] Univ Calif Berkeley, Dept Earth & Planetary Sci, Berkeley, CA 94720 USA. [Kozlowicz, B.; Simpson, D.] URS Corp, Oakland, CA 94104 USA. [Streig, A.] Univ Oregon, Dept Geol Sci, Eugene, OR 97403 USA. [Rose, R.] USA, Corps Engineers, Dam Safety Assurance Program, Sacramento, CA 95814 USA. RP Brossy, CC (reprint author), Fugro Consultants Inc, 1777 Botelho Dr, Walnut Creek, CA 94596 USA. EM c.brossy@fugro.com RI Amos, Colin/B-2397-2008 OI Amos, Colin/0000-0002-3862-9344 NR 52 TC 7 Z9 7 U1 0 U2 5 PU GEOLOGICAL SOC AMER, INC PI BOULDER PA PO BOX 9140, BOULDER, CO 80301-9140 USA SN 1553-040X J9 GEOSPHERE JI Geosphere PD JUN PY 2012 VL 8 IS 3 BP 581 EP 591 DI 10.1130/GES00663.1 PG 11 WC Geosciences, Multidisciplinary SC Geology GA 008EN UT WOS:000308940300004 ER PT J AU Mason, GL Gates, BQ Moore, VD AF Mason, George L. Gates, Burhman Q. Moore, Victoria D. TI Determining forces required to override obstacles for ground vehicles SO JOURNAL OF TERRAMECHANICS LA English DT Article DE Obstacle; Force; Velocity; Vegetation; Mobility; Override; Trees; Modeling; Tests AB The military is constantly expanding the use of unmanned ground vehicles in warfighting applications that often involve complex environments. Part of the focus of military research is to improve or validate existing routing algorithms which are used to predict vehicle mobility. Routing algorithms are based on the time required for vehicle movement through a series of obstacles such as trees or fences, thus requiring an assessment of the ability to override such obstacles as compared to finding an alternate maneuver path. The required overriding force can be computed and compared to a vehicle's tractive force to determine the best viable option. If overriding the obstacle is an option (tractive force exceeds the required overriding force), the delay in overriding can be assessed as compared to the delay in maneuvering around the obstacle. This study provides a quick and reasonable calculation of the force required to override specific types of vertically embedded obstacles to support the determination of movement capabilities for unmanned ground vehicles on the battlefield. Published by Elsevier Ltd. on behalf of ISTVS. C1 [Mason, George L.; Gates, Burhman Q.; Moore, Victoria D.] USA, Engineer Res & Dev Ctr, Geotech & Struct Lab, Washington, DC USA. RP Mason, GL (reprint author), USA, Engineer Res & Dev Ctr, Geotech & Struct Lab, Washington, DC USA. EM George.L.Mason@us.army.mil; Burhman.Gates@us.army.mil; Victoria.D.Moore@us.army.mil NR 7 TC 5 Z9 5 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0022-4898 J9 J TERRAMECHANICS JI J. Terramech. PD JUN-AUG PY 2012 VL 49 IS 3-4 BP 191 EP 196 DI 10.1016/j.jterra.2012.04.001 PG 6 WC Engineering, Environmental SC Engineering GA 001GD UT WOS:000308447700006 ER PT J AU Lever, JH Weale, JC AF Lever, James H. Weale, Jason C. TI High efficiency fuel sleds for polar traverses SO JOURNAL OF TERRAMECHANICS LA English DT Article DE Over-snow mobility; Sliding friction; Transport efficiency; Polar resupply operations ID SNOW; POLYETHYLENE AB We describe here the evolution of lightweight, high-efficiency fuel sleds for Polar over-snow traverses. These sleds consist of flexible bladders strapped to sheets of high molecular weight polyethylene. They cost 1/6th, weigh 1/10th and triple the fuel delivered per towing tractor compared with steel sleds. An eight-tractor fleet has conducted three 3400-km roundtrips to South Pole with each traverse delivering 320,000 kg of fuel while emitting <1% the pollutants, consuming 1/2 the fuel and saving similar to$1.6 M compared with aircraft resupply. A two-tractor fleet in Greenland recently delivered 83,000 kg of fuel in bladder sleds to Summit with similar benefits. Performance monitoring has revealed that bladder-sled towing resistance is largely governed by sliding friction, which can start high and drop in half over the first 30 min of travel. Frictional heating probably produces a thin water layer that lubricates the sled-snow interface. Consequently, towing resistance depends on the thermal budget of the sled. For example, black fuel bladders increase solar gain and thus decrease sled resistance; data suggest they could double again the fuel delivered per tractor. The outstanding efficiency and low cost of these sleds has transformed fuel delivery to Polar research stations. Published by Elsevier Ltd. on behalf of ISTVS. C1 [Lever, James H.; Weale, Jason C.] USA, Ctr Res & Dev, CRREL, Hanover, NH 03755 USA. RP Lever, JH (reprint author), USA, Ctr Res & Dev, CRREL, 72 Lyme Rd, Hanover, NH 03755 USA. EM james.lever@us.army.mil; jason.weale@us.army.mil NR 12 TC 3 Z9 3 U1 0 U2 3 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0022-4898 J9 J TERRAMECHANICS JI J. Terramech. PD JUN-AUG PY 2012 VL 49 IS 3-4 BP 207 EP 213 DI 10.1016/j.jterra.2012.05.001 PG 7 WC Engineering, Environmental SC Engineering GA 001GD UT WOS:000308447700008 ER PT J AU Anderson, K Gibbons, RV Rothman, AL Berkelman, R Endy, TP AF Anderson, K. Gibbons, R. V. Rothman, A. L. Berkelman, R. Endy, T. P. TI A shorter time interval between first and second dengue infections is associated with protection from clinical illness in a prospective school-based cohort in Thailand SO INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES LA English DT Meeting Abstract C1 [Anderson, K.; Berkelman, R.] Rollins Sch Publ Hlth, Atlanta, GA USA. [Gibbons, R. V.] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Rothman, A. L.] Univ Rhode Isl, Providence, RI 02908 USA. [Endy, T. P.] SUNY Syracuse, Syracuse, NY USA. NR 0 TC 0 Z9 0 U1 0 U2 4 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1201-9712 J9 INT J INFECT DIS JI Int. J. Infect. Dis. PD JUN PY 2012 VL 16 SU 1 BP E82 EP E83 DI 10.1016/j.ijid.2012.05.197 PG 2 WC Infectious Diseases SC Infectious Diseases GA 999YX UT WOS:000308353100182 ER PT J AU Chusri, S Siripaitoon, P Silpapojakul, K Hortiwakul, T Nisalak, A Thaisomboonsuk, B Klungthong, C Gibbons, RV Jarman, R AF Chusri, S. Siripaitoon, P. Silpapojakul, K. Hortiwakul, T. Nisalak, A. Thaisomboonsuk, B. Klungthong, C. Gibbons, R. V. Jarman, R. TI Kinetics of Chikungunya infection during an outbreak in southern Thailand, 2009 SO INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES LA English DT Meeting Abstract C1 [Chusri, S.; Siripaitoon, P.; Silpapojakul, K.; Hortiwakul, T.] Prince Songkla Univ, Hat Yai, Thailand. [Nisalak, A.; Thaisomboonsuk, B.; Klungthong, C.; Gibbons, R. V.; Jarman, R.] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. NR 0 TC 0 Z9 0 U1 0 U2 2 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1201-9712 J9 INT J INFECT DIS JI Int. J. Infect. Dis. PD JUN PY 2012 VL 16 SU 1 BP E251 EP E251 DI 10.1016/j.ijid.2012.05.884 PG 1 WC Infectious Diseases SC Infectious Diseases GA 999YX UT WOS:000308353101206 ER PT J AU Dumre, SP Na-Bangchang, K Eursitthichai, V Viyanant, V Grams, R Shakya, G Klungthong, C Nisalak, A Fernandez, S AF Dumre, S. P. Na-Bangchang, K. Eursitthichai, V. Viyanant, V. Grams, R. Shakya, G. Klungthong, C. Nisalak, A. Fernandez, S. TI Molecular characterization of dengue virus from Nepal SO INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES LA English DT Meeting Abstract C1 [Dumre, S. P.; Na-Bangchang, K.; Eursitthichai, V.; Viyanant, V.; Grams, R.] Thammasat Univ, Fac Allied Hlth Sci, Pathum Thani 12121, Thailand. [Shakya, G.] Natl Publ Hlth Lab, Kathmandu, Nepal. [Klungthong, C.; Nisalak, A.; Fernandez, S.] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. NR 0 TC 0 Z9 0 U1 0 U2 3 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1201-9712 J9 INT J INFECT DIS JI Int. J. Infect. Dis. PD JUN PY 2012 VL 16 SU 1 BP E77 EP E77 DI 10.1016/j.ijid.2012.05.186 PG 1 WC Infectious Diseases SC Infectious Diseases GA 999YX UT WOS:000308353100171 ER PT J AU Ibadova, G Musabaev, E Juraev, R Khodiev, A Abdukhalilova, G Madiyarov, R Merkushkina, T Mason, C Bodhidatta, L AF Ibadova, G. Musabaev, E. Juraev, R. Khodiev, A. Abdukhalilova, G. Madiyarov, R. Merkushkina, T. Mason, C. Bodhidatta, L. TI Epidemiological and genetic aspects of rotavirus gastroenteritis in Uzbekistan SO INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES LA English DT Meeting Abstract C1 [Ibadova, G.; Khodiev, A.; Madiyarov, R.; Merkushkina, T.] Tashkent Inst Postgrad Med Educ, Tashkent, Uzbekistan. [Musabaev, E.; Juraev, R.] Res Inst Virol, Tashkent, Uzbekistan. [Abdukhalilova, G.] Epidemiol Microbiol & Infect Dis Res Inst, Tashkent, Uzbekistan. [Mason, C.; Bodhidatta, L.] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. NR 0 TC 0 Z9 0 U1 0 U2 1 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1201-9712 J9 INT J INFECT DIS JI Int. J. Infect. Dis. PD JUN PY 2012 VL 16 SU 1 BP E86 EP E86 DI 10.1016/j.ijid.2012.05.201 PG 1 WC Infectious Diseases SC Infectious Diseases GA 999YX UT WOS:000308353100186 ER PT J AU Khuntirat, B Yoon, IK Krueger, W Chittaganrnpitch, M Supawat, K Blair, P Putnam, SD Gibbons, RV Sawanpanyalert, P Heil, GL Friary, JA Gray, GC AF Khuntirat, B. Yoon, I. -K. Krueger, W. Chittaganrnpitch, M. Supawat, K. Blair, P. Putnam, S. D. Gibbons, R. V. Sawanpanyalert, P. Heil, G. L. Friary, J. A. Gray, G. C. TI Pandemic influenza A (H1N1) virus infections among villagers living in rural Thailand SO INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES LA English DT Meeting Abstract C1 [Khuntirat, B.; Yoon, I. -K.; Gibbons, R. V.] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Krueger, W.; Heil, G. L.; Friary, J. A.; Gray, G. C.] Univ Florida, Coll Publ Hlth & Hlth Profess, Gainesville, FL USA. [Chittaganrnpitch, M.; Supawat, K.; Sawanpanyalert, P.] Thai Natl Inst Hlth, Nonthaburi, Thailand. [Blair, P.] USN, Hlth Res Ctr, San Diego, CA 92152 USA. [Putnam, S. D.] JMI Labs, N Liberty, IA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1201-9712 J9 INT J INFECT DIS JI Int. J. Infect. Dis. PD JUN PY 2012 VL 16 SU 1 BP E348 EP E348 DI 10.1016/j.ijid.2012.05.424 PG 1 WC Infectious Diseases SC Infectious Diseases GA 999YX UT WOS:000308353101410 ER PT J AU Klungthong, C Charoensri, N Pobkeeree, V Hussem, K Fernandez, S Bauer, KM AF Klungthong, C. Charoensri, N. Pobkeeree, V. Hussem, K. Fernandez, S. Bauer, K. M. TI Evaluation of influenza RT-PCR assay competency SO INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES LA English DT Meeting Abstract C1 [Klungthong, C.; Charoensri, N.; Pobkeeree, V.; Hussem, K.; Fernandez, S.; Bauer, K. M.] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. NR 0 TC 0 Z9 0 U1 0 U2 1 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1201-9712 J9 INT J INFECT DIS JI Int. J. Infect. Dis. PD JUN PY 2012 VL 16 SU 1 BP E471 EP E471 DI 10.1016/j.ijid.2012.05.682 PG 1 WC Infectious Diseases SC Infectious Diseases GA 999YX UT WOS:000308353102036 ER PT J AU Rabaa, M Klungthong, C Yoon, IK Holmes, EC Chinnawirotpisan, P Thaisomboonsuk, B Rothman, AL Tannitisupawong, D Aldstadt, J Nisalak, A Mammen, MP Thammapalo, S Gibbons, RV Endy, TP Fansiri, T Pimgate, C Scott, TW Jarman, R AF Rabaa, M. Klungthong, C. Yoon, I-K. Holmes, E. C. Chinnawirotpisan, P. Thaisomboonsuk, B. Rothman, A. L. Tannitisupawong, D. Aldstadt, J. Nisalak, A. Mammen, M. P., Jr. Thammapalo, S. Gibbons, R. V. Endy, T. P. Fansiri, T. Pimgate, C. Scott, T. W. Jarman, R. TI Frequent in-migration and highly focal transmission of dengue viruses among children in Kamphaeng Phet, Thailand SO INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES LA English DT Meeting Abstract C1 [Rabaa, M.; Holmes, E. C.] Penn State Univ, University Pk, PA 16802 USA. [Klungthong, C.; Yoon, I-K.; Chinnawirotpisan, P.; Tannitisupawong, D.; Nisalak, A.; Mammen, M. P., Jr.; Gibbons, R. V.; Fansiri, T.; Pimgate, C.; Jarman, R.] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Thaisomboonsuk, B.] USAMC AFRIMS, Bangkok, Thailand. [Rothman, A. L.] Univ Rhode Isl, Providence, RI 02908 USA. [Aldstadt, J.] SUNY Buffalo, Buffalo, NY 14260 USA. [Thammapalo, S.] Bur Vector Borne Dis, Nonthaburi, Thailand. [Endy, T. P.] SUNY Syracuse, Syracuse, NY USA. [Scott, T. W.] Univ Calif Davis, Davis, CA 95616 USA. RI Aldstadt, Jared/A-8508-2009 OI Aldstadt, Jared/0000-0001-9162-7439 NR 0 TC 0 Z9 0 U1 0 U2 4 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1201-9712 J9 INT J INFECT DIS JI Int. J. Infect. Dis. PD JUN PY 2012 VL 16 SU 1 BP E90 EP E91 DI 10.1016/j.ijid.2012.05.211 PG 2 WC Infectious Diseases SC Infectious Diseases GA 999YX UT WOS:000308353100196 ER PT J AU Thaisomboonsuk, B Jarman, R Gibbons, RV Nisalak, A Klungthong, C Yoon, IK Thomas, S Endy, TP Rothman, AL Scott, TW AF Thaisomboonsuk, B. Jarman, R. Gibbons, R. V. Nisalak, A. Klungthong, C. Yoon, I. -K. Thomas, S. Endy, T. P. Rothman, A. L. Scott, T. W. TI Considerations for changing PRNT Dengue 4 reference viruses: sub- optimal immunity to documented infections SO INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES LA English DT Meeting Abstract C1 [Thaisomboonsuk, B.; Thomas, S.] USAMC AFRIMS, Bangkok, Thailand. [Jarman, R.; Gibbons, R. V.; Nisalak, A.; Klungthong, C.; Yoon, I. -K.] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Endy, T. P.] SUNY Syracuse, Syracuse, NY USA. [Rothman, A. L.] Univ Rhode Isl, Providence, RI 02908 USA. [Scott, T. W.] Univ Calif Davis, Davis, CA 95616 USA. NR 0 TC 1 Z9 1 U1 0 U2 3 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1201-9712 J9 INT J INFECT DIS JI Int. J. Infect. Dis. PD JUN PY 2012 VL 16 SU 1 BP E113 EP E114 DI 10.1016/j.ijid.2012.05.261 PG 2 WC Infectious Diseases SC Infectious Diseases GA 999YX UT WOS:000308353100246 ER PT J AU Tomayao, A Yoon, IK Tac-an, I Macasocol, D Obidas, D Ygona, S Coberly, J Wojcik, R Alera, MT Velasco, JM Fernandez, T AF Tomayao, A. Yoon, I. -K. Tac-an, I. Macasocol, D. Obidas, D. Ygona, S. Coberly, J. Wojcik, R. Alera, M. T. Velasco, J. M. Fernandez, T. TI Implementation of SMS fever surveillance in the Philippines SO INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES LA English DT Meeting Abstract C1 [Tomayao, A.; Obidas, D.; Alera, M. T.] Philippines AFRIMS Virol Res Unit, Cebu, Philippines. [Yoon, I. -K.; Velasco, J. M.] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Tac-an, I.; Macasocol, D.; Ygona, S.; Fernandez, T.] Cebu City Hlth Dept, Cebu, Philippines. [Coberly, J.] Johns Hopkins Univ, Appl Phys Lab, Laurel, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1201-9712 J9 INT J INFECT DIS JI Int. J. Infect. Dis. PD JUN PY 2012 VL 16 SU 1 BP E147 EP E147 DI 10.1016/j.ijid.2012.05.332 PG 1 WC Infectious Diseases SC Infectious Diseases GA 999YX UT WOS:000308353100317 ER PT J AU Yoon, IK Nisaluk, A Kalayanarooj, S Klungthong, C Thaisomboonsuk, B Bhoomiboonchoo, P Gibbons, RV AF Yoon, I. -K. Nisaluk, A. Kalayanarooj, S. Klungthong, C. Thaisomboonsuk, B. Bhoomiboonchoo, P. Gibbons, R. V. TI Serotype-specific dengue virus circulation and dengue disease in Bangkok, Thailand from 1973 to 2010 SO INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES LA English DT Meeting Abstract C1 [Yoon, I. -K.; Klungthong, C.; Gibbons, R. V.] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Nisaluk, A.; Thaisomboonsuk, B.; Bhoomiboonchoo, P.] USAMC AFRIMS, Bangkok, Thailand. [Kalayanarooj, S.] Queen Sirikit Natl Inst Child Hlth, Bangkok, Thailand. NR 0 TC 0 Z9 0 U1 0 U2 1 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1201-9712 J9 INT J INFECT DIS JI Int. J. Infect. Dis. PD JUN PY 2012 VL 16 SU 1 BP E141 EP E141 DI 10.1016/j.ijid.2012.05.319 PG 1 WC Infectious Diseases SC Infectious Diseases GA 999YX UT WOS:000308353100304 ER PT J AU Warren, B AF Warren, Brittany TI "If You Have a Zero-Tolerance Policy, Why Aren't You Doing Anything?": Using the Uniform Code of Military Justice to Combat Human Trafficking Abroad SO GEORGE WASHINGTON LAW REVIEW LA English DT Article AB Human trafficking is a long-recognized problem with global implications. Officially, the U.S. Government has a "zero-tolerance" policy for human trafficking. To that end, the United States has enacted a variety of legislation since 2000 to combat human trafficking both at home and abroad. The over 600,000 individuals who are trafficked each year, however, are evidence that these laws are insufficient. Specifically, the current legal framework leaves significant jurisdictional, evidentiary, and motivational hurdles When It comes to applying that framework to crimes committed by civilian contractors abroad. In 2007, article 2(a) (10) of the Uniform Code of Military Justice ("UCMJ") was amended to explicitly provide courts-martial jurisdiction over all civilian personnel accompanying troops abroad in support of a Department of Defense mission, whether that mission is war or a contingency operation. Congress should further amend the UCMJ's punitive articles to reach conduct that might otherwise fall through the gaps in existing antitrafficking laws. This Note sets out a proposed punitive article that, by operating concurrently with existing federal law, gives true effect to the U.S. Government's zero-tolerance policy. C1 USA, Washington, DC 20310 USA. RP Warren, B (reprint author), USA, Washington, DC 20310 USA. NR 77 TC 2 Z9 2 U1 1 U2 10 PU GEORGE WASHINGTON UNIV PI WASHINGTON PA 2000 H STREET N W, WASHINGTON, DC 20052 USA SN 0016-8076 J9 GEORGE WASH LAW REV JI George Wash. Law Rev. PD JUN PY 2012 VL 80 IS 4 BP 1255 EP 1292 PG 38 WC Law SC Government & Law GA 974OX UT WOS:000306447000006 ER PT J AU Aldridge, JM Sturdy, JT Wilken, JM AF Aldridge, Jennifer M. Sturdy, Jordan T. Wilken, Jason M. TI Stair ascent kinematics and kinetics with a powered lower leg system following transtibial amputation SO GAIT & POSTURE LA English DT Article DE Stair ascent; Transtibial; Biomechanics; Amputee; Powered prosthesis ID BIOMECHANICAL ANALYSIS; HEALTHY-ADULTS; AMPUTEE GAIT; KNEE; AMBULATION; WALKING; FEEDBACK; MOTION; ANKLE; HIP AB During stair ascent (STA) persons with transtibial amputation (TEA) typically adopt a hip strategy to compensate for the limited ankle motion and joint power that is characteristic of conventional energy storing and returning (ESR) prosthetic feet. The purpose of this investigation was to determine if providing ankle power via a powered prosthetic device (BiOM) normalized STA kinematics and kinetics. Eleven individuals with TTA participated in two STA gait analysis sessions: (1) using an ESR foot, and (2) using the BiOM. Eleven height and weight matched able-bodied controls (CONT) were also assessed. Lower extremity peak kinematic and kinetic values were calculated at a self-selected and controlled cadence (80 steps/min). Increased prosthetic limb peak ankle plantarflexion and push-up power were observed while using the BiOM as compared to ESR. Peak ankle power was not significantly different between BiOM and CONT indicating normalization of ankle power generation. However, peak ankle plantarflexion was significantly lower than CONT. Limb asymmetries including greater prosthetic limb hip flexion and power during stance, and decreased prosthetic limb knee power during stance were observed in the BiOM and ESR conditions. The results suggest that the BiOM successfully increased ankle motion and restored ankle power during STA. These differences did not, however, reduce the use of a hip strategy while ascending stairs. Additional device specific training may be necessary to utilize the full benefits of the device. Published by Elsevier B.V. C1 [Aldridge, Jennifer M.; Sturdy, Jordan T.; Wilken, Jason M.] Brooke Army Med Ctr, Ctr Intrepid, Dept Orthopaed & Rehabil, Ft Sam Houston, TX 78234 USA. RP Wilken, JM (reprint author), Brooke Army Med Ctr, Ctr Intrepid, Dept Orthopaed & Rehabil, Ft Sam Houston, TX 78234 USA. EM Jason.Wilken@us.army.mil OI Wilken, Jason/0000-0002-5556-7667 FU U.S. Army Telemedicine and Advanced Technology Research Center; Center for Rehabilitation Sciences Research FX Support partially provided by the U.S. Army Telemedicine and Advanced Technology Research Center (to JMW) and by The Center for Rehabilitation Sciences Research. NR 24 TC 11 Z9 11 U1 2 U2 17 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0966-6362 J9 GAIT POSTURE JI Gait Posture PD JUN PY 2012 VL 36 IS 2 BP 291 EP 295 DI 10.1016/j.gaitpost.2012.03.013 PG 5 WC Neurosciences; Orthopedics; Sport Sciences SC Neurosciences & Neurology; Orthopedics; Sport Sciences GA 976YP UT WOS:000306623600023 PM 22571821 ER PT J AU Alving, CR Peachman, KK Rao, M Reed, SG AF Alving, Carl R. Peachman, Kristina K. Rao, Mangala Reed, Steven G. TI Adjuvants for human vaccines SO CURRENT OPINION IN IMMUNOLOGY LA English DT Review ID MALARIA VACCINE; TRANSCUTANEOUS IMMUNIZATION; EPICUTANEOUS IMMUNIZATION; INFLUENZA VACCINE; ANIMAL-MODELS; INDUCTION; IMMUNITY; TRIAL; SKIN; TUBERCULOSIS AB Rational selection of individual adjuvants can often be made on the basis of innate molecular interactions of the foreign molecules with pattern recognition receptors such as Toll-like receptors. For example, monophosphoryl lipid A, a family of endotoxic TLR4 agonist molecules from bacteria, has recently been formulated with liposomes, oil emulsions, or aluminum salts for several vaccines. Combinations of antigens and adjuvants with particulate lipid or oil components may reveal unique properties of immune potency or efficacy, but these can sometimes be exhibited differently in rodents when compared to nonhuman primates or humans. New adjuvants, formulations, microinjection devices, and skin delivery techniques for transcutaneous immunization demonstrate that adjuvant systems can include combinations of strategies and delivery mechanisms for uniquely formulated antigens and adjuvants. C1 [Alving, Carl R.; Peachman, Kristina K.; Rao, Mangala] Walter Reed Army Inst Res, US Mil HIV Res Program, Lab Adjuvant & Antigen Res, Silver Spring, MD 20910 USA. [Reed, Steven G.] Infect Dis Res Inst, Seattle, WA 98104 USA. RP Alving, CR (reprint author), Walter Reed Army Inst Res, US Mil HIV Res Program, Lab Adjuvant & Antigen Res, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM calving@hivresearch.org FU Henry M. Jackson Foundation for the Advancement of Military Medicine [W81XWH-07-2-067]; U.S. Army Medical Research and Materiel Command [W81XWH-07-2-067]; National Institute of Allergy and Infectious Diseases [R01AI025038, R01AI044373]; Bill and Melinda Gates Foundation [42387] FX This work was supported through a Cooperative Agreement contract (no. W81XWH-07-2-067) between the Henry M. Jackson Foundation for the Advancement of Military Medicine and the U.S. Army Medical Research and Materiel Command. Work was also supported by Grants R01AI025038 and R01AI044373 from the National Institute of Allergy and Infectious Diseases and Grant 42387 from the Bill and Melinda Gates Foundation (S. Reed). The views expressed in this article are those of the authors and do not reflect the official policy of the Department of the Army, Department of Defense, or the U.S. Government, the National Institute of Allergy and Infectious Diseases, the National Institutes of Health or the Bill and Melinda Gates Foundation. NR 48 TC 74 Z9 76 U1 2 U2 31 PU CURRENT BIOLOGY LTD PI LONDON PA 84 THEOBALDS RD, LONDON WC1X 8RR, ENGLAND SN 0952-7915 J9 CURR OPIN IMMUNOL JI Curr. Opin. Immunol. PD JUN PY 2012 VL 24 IS 3 BP 310 EP 315 DI 10.1016/j.coi.2012.03.008 PG 6 WC Immunology SC Immunology GA 974QA UT WOS:000306450200011 PM 22521140 ER PT J AU Pinsker, JE AF Pinsker, Jordan E. TI Turner Syndrome: Updating the Paradigm of Clinical Care SO JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM LA English DT Article ID GROWTH-HORMONE TREATMENT; BONE-MINERAL DENSITY; GH-TREATED GIRLS; TERM-FOLLOW-UP; FINAL HEIGHT; INTRACRANIAL HYPERTENSION; ESTROGEN REPLACEMENT; PRENATAL-DIAGNOSIS; AORTIC DILATATION; BODY-COMPOSITION AB Context: Turner syndrome (TS), in which there is loss of all or part of one sex chromosome, occurs in one in 2500 live-born females and is associated with characteristic findings. Detailed healthcare checklists and screening guidelines are commonly used to detect known complications affecting individuals with TS. Even with the use of these guidelines, there remains an increased morbidity and mortality seen in TS as compared to the general population, leading to significant controversy on optimal management of several aspects of TS. Evidence Acquisition and Synthesis: A PubMed search of articles from the past 15 yr identified available studies related to the diagnosis and management of common issues related to TS as well as important historical articles. This review summarizes studies through January 2012 and highlights recent developments. Conclusions: There remain many areas of uncertainty in the diagnosis and management of TS. Generalizations from experience in the care of other conditions in isolation (such as poor growth, follow-up of cardiac disease, or the treatment of ovarian failure) cannot be broadly applied when caring for individuals with TS. Specific differences include treatment of growth failure as early as possible; acquisition of adequate baseline cardiac studies, followed by serial magnetic resonance imaging, targeted to identify findings unique to TS that address the increased risk of aortic dissection; initiation of hormone replacement at the normal age of puberty, preferentially with transdermal estradiol; and detailed patient counseling to explain the long-term health risks commonly associated with this disorder. A revised paradigm of care using a standardized multidisciplinary evaluation, supplementing screening tests as advocated by expert opinion guidelines, can aid clinicians in interpreting the results of diagnostic testing in the context of TS. This approach optimizes medical care for women with TS and may reduce the increased morbidity and mortality currently seen in this population. (J Clin Endocrinol Metab 97: E994-E1003, 2012) C1 Tripler Army Med Ctr, Dept Pediat, Div Pediat Endocrinol, Mail Code MCHK PE, Honolulu, HI 96859 USA. RP Pinsker, JE (reprint author), Tripler Army Med Ctr, Dept Pediat, Div Pediat Endocrinol, Mail Code MCHK PE, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM jordan.pinsker@us.army.mil OI Pinsker, Jordan/0000-0003-4080-9034 NR 122 TC 29 Z9 33 U1 0 U2 19 PU ENDOCRINE SOC PI CHEVY CHASE PA 8401 CONNECTICUT AVE, SUITE 900, CHEVY CHASE, MD 20815-5817 USA SN 0021-972X J9 J CLIN ENDOCR METAB JI J. Clin. Endocrinol. Metab. PD JUN PY 2012 VL 97 IS 6 BP E994 EP E1003 DI 10.1210/jc.2012-1245 PG 10 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA 970AP UT WOS:000306100800017 PM 22472565 ER PT J AU Corron, NJ Blakely, JN Stahl, MT AF Corron, Ned J. Blakely, Jonathan N. Stahl, Mark T. TI A matched filter for chaos (vol 20, 023123, 2010) SO CHAOS LA English DT Correction C1 [Corron, Ned J.; Blakely, Jonathan N.; Stahl, Mark T.] USA, Res Dev & Engn Command, RDMR WSS, Redstone Arsenal, AL 35898 USA. RP Corron, NJ (reprint author), USA, Res Dev & Engn Command, RDMR WSS, Redstone Arsenal, AL 35898 USA. EM ned.corron@us.army.mil OI Corron, Ned/0000-0002-3232-5024 NR 2 TC 2 Z9 2 U1 0 U2 2 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 1054-1500 J9 CHAOS JI Chaos PD JUN PY 2012 VL 22 IS 2 AR 029901 DI 10.1063/1.4729138 PG 1 WC Mathematics, Applied; Physics, Mathematical SC Mathematics; Physics GA 966JM UT WOS:000305833900077 ER PT J AU Corron, NJ Blakely, JN AF Corron, Ned J. Blakely, Jonathan N. TI Exact folded-band chaotic oscillator SO CHAOS LA English DT Article ID BIOLOGICAL OSCILLATORS; EQUATION; SYSTEMS; MODEL AB An exactly solvable chaotic oscillator with folded-band dynamics is shown. The oscillator is a hybrid dynamical system containing a linear ordinary differential equation and a nonlinear switching condition. Bounded oscillations are provably chaotic, and successive waveform maxima yield a one-dimensional piecewise-linear return map with segments of both positive and negative slopes. Continuous-time dynamics exhibit a folded-band topology similar to Rossler's oscillator. An exact solution is written as a linear convolution of a fixed basis pulse and a discrete binary sequence, from which an equivalent symbolic dynamics is obtained. The folded-band topology is shown to be dependent on the symbol grammar. [http://dx.doi.org/10.1063/1.4704813] C1 [Corron, Ned J.; Blakely, Jonathan N.] USA, RDECOM, RDMR WSS, Redstone Arsenal, AL 35898 USA. RP Corron, NJ (reprint author), USA, RDECOM, RDMR WSS, Redstone Arsenal, AL 35898 USA. EM ned.corron@us.army.mil OI Corron, Ned/0000-0002-3232-5024; Blakely, Jonathan/0000-0002-9772-582X NR 24 TC 13 Z9 13 U1 0 U2 8 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 1054-1500 J9 CHAOS JI Chaos PD JUN PY 2012 VL 22 IS 2 AR 023113 DI 10.1063/1.4704813 PG 7 WC Mathematics, Applied; Physics, Mathematical SC Mathematics; Physics GA 966JM UT WOS:000305833900013 PM 22757520 ER PT J AU Jiang, RZ Tran, DT McClure, J Chu, D AF Jiang, Rongzhong Tran, Dat T. McClure, Joshua Chu, Deryn TI Heat-treated hemin supported on graphene nanoplatelets for the oxygen reduction reaction SO ELECTROCHEMISTRY COMMUNICATIONS LA English DT Article DE Hemin; Graphene; ORR catalysts; Ultrasound; Fuel cell ID CARBON; ELECTROCATALYSTS; CATALYSTS; METHANOL; COBALT; IRON AB A bio-material. hemin, was heat-treated and used as an oxygen reduction reaction (ORR) electrocatalyst. In addition to heat-treatment, two methods were used to improve the catalysts' electrochemical activity. First, high surface area graphene nanoplatelets (GNP) were chosen as a catalyst support. Second, ultrasound was used to break the catalyst samples into smaller pieces. Hemin supported on GNP and heat-treated at 600 degrees C showed significantly higher catalytic activity than those without ultrasonic treatment. Furthermore, a single fuel cell fabricated with the synthesized catalyst yielded a power density of 300 mW cm(-2). Published by Elsevier B.V. C1 [Jiang, Rongzhong; Tran, Dat T.; Chu, Deryn] USA, Res Lab, RDRL SED C, Adelphi, MD 20783 USA. [McClure, Joshua] N Carolina State Univ, Raleigh, NC 27695 USA. RP Jiang, RZ (reprint author), USA, Res Lab, RDRL SED C, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM Rongzhong.jiang.civ@mail.mil FU U.S. Department of the Army; U.S. Army Materiel Command FX The authors wish to thank Dr. Li-Chung Lai at University of Maryland for assisting TEM analysis, and the U.S. Department of the Army and U.S. Army Materiel Command for financial support. NR 9 TC 27 Z9 28 U1 4 U2 62 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1388-2481 J9 ELECTROCHEM COMMUN JI Electrochem. Commun. PD JUN PY 2012 VL 19 BP 73 EP 76 DI 10.1016/j.elecom.2012.03.013 PG 4 WC Electrochemistry SC Electrochemistry GA 965KW UT WOS:000305767700020 ER PT J AU Snook, M Hearne, H McNutt, T Veliadis, V El-Hinnawy, N Nechay, B Woodruff, S Stahlbush, RE Howell, RS Giorgi, D White, J Davis, S AF Snook, M. Hearne, H. McNutt, T. Veliadis, V. El-Hinnawy, N. Nechay, B. Woodruff, S. Stahlbush, R. E. Howell, R. S. Giorgi, D. White, J. Davis, S. TI 11.72-cm(2) Active-Area Wafer-Interconnected p-i-n Diode Pulsed at 64 kA Dissipates 382 J and Exhibits an Action of 1.7 MA(2) . s SO IEEE ELECTRON DEVICE LETTERS LA English DT Article DE Action; di/dt; full-wafer diode; high voltage; P-i-n diode; pulsed power; wafer interconnection; 4H-SiC ID ASSISTED REVERSE BREAKDOWN; P(+)N JUNCTION DIODES; BULK; KV AB SiC device area is currently limited by material and processing defects. To meet the large current handling requirements of modern power conditioning systems, paralleling of a large number of devices is required. This can increase cost and complexity through dicing, soldering, inclusion of ballast resistors, and forming multiple wire bonds. Furthermore, paralleling numerous discrete devices increases package volume/weight and reduces power density. To overcome these complexities, p-i-n diodes were designed, fabricated at a yield of 83%, and interconnected on a 3-in 4H-SiC wafer to form an 11.72-cm(2) active-area full-wafer diode. The full-wafer diode exhibited a breakdown voltage of 1790 V at an extremely low leakage current density of less than 0.002 mA/cm(2). At a pulsed current density of 5.5 kA/cm(2) and a rise time of di/dt = 1.1 kA/mu s, the peak current through the wafer-interconnected diode was 64.3 kA with a forward-voltage drop of 10.3 V. The dissipated energy was 382 J, and the calculated action exceeded 1.7 MA(2) center dot s. Preliminary efforts on high-voltage diode interconnection have produced quarter-wafer-interconnected p-i-n diodes with breakdown voltages of 4 and 4.5 kV and active areas of 3.1 and 2.2 cm(2), respectively. C1 [Snook, M.; Hearne, H.; Veliadis, V.; El-Hinnawy, N.; Nechay, B.; Woodruff, S.; Howell, R. S.] Northrop Grumman Elect Syst, Linthicum, MD 21090 USA. [McNutt, T.] APEI Inc, Fayetteville, AR 72701 USA. [Stahlbush, R. E.] USN, Res Lab, Washington, DC 20375 USA. [Giorgi, D.] Omnipulse Inc, San Diego, CA 92121 USA. [White, J.; Davis, S.] USA, Tank Automot Res, Ctr Dev & Engn, Warren, MI 48397 USA. RP Snook, M (reprint author), Northrop Grumman Elect Syst, Linthicum, MD 21090 USA. FU U.S. Army Tank Automotive Research, Development, and Engineering Center FX This work was supported by the U.S. Army Tank Automotive Research, Development, and Engineering Center. Reference herein to any specific commercial company, product, process, or service by trade name, trademark, manufacturer, or otherwise, does not necessarily constitute or imply its endorsement, recommendation, or favoring by the United States Government or the Department of the Army (DoA). The opinions of the authors expressed herein do not necessarily state or reflect those of the United States Government or the DoA, and shall not be used for advertising or product endorsement purposes. The review of this letter was arranged by Editor S.-H. Ryu. NR 8 TC 3 Z9 3 U1 0 U2 1 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0741-3106 J9 IEEE ELECTR DEVICE L JI IEEE Electron Device Lett. PD JUN PY 2012 VL 33 IS 6 BP 764 EP 766 DI 10.1109/LED.2012.2192089 PG 3 WC Engineering, Electrical & Electronic SC Engineering GA 966JX UT WOS:000305835000008 ER PT J AU Ho, JN Jow, TR AF Ho, Janet Jow, T. Richard TI High Field Conduction in Biaxially Oriented Polypropylene at Elevated Temperature SO IEEE TRANSACTIONS ON DIELECTRICS AND ELECTRICAL INSULATION LA English DT Article DE Biaxially oriented polypropylene (BOPP); electrical conductivity; breakdown strength; activation energy; charge transport mechanism ID ELECTRICAL-CONDUCTION; DIELECTRIC POLYETHYLENE; INSULATING POLYMERS; IMPURITIES; BREAKDOWN; ELECTRODE; FILMS AB Although biaxially-oriented polypropylene thin film is a common dielectric for many high voltage pulsed power capacitor applications, the electrical conductivity under high field at elevated temperature is mostly unknown. Such knowledge is valuable not only for better understanding of the origin and transport mechanisms of the charge species at high field, but also for gaining insight for improving breakdown strength and electro-thermal modeling of high energy density, pulsed power capacitors. In this work, the conduction mechanism was investigated and the conductivities near breakdown were inferred through the use of a thermal runaway criterion and the measured breakdown strength at various temperatures. Results suggested that conduction is by hopping with a thermal activation energy that is about 0.76 eV and is field-independent. Such finding allows the use of an Arrhenius term and a field-dependent term to describe the field-dependent conductivity up to breakdown. C1 [Ho, Janet; Jow, T. Richard] USA, Res Lab, Adelphi, MD 20873 USA. RP Ho, JN (reprint author), USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20873 USA. NR 24 TC 27 Z9 27 U1 3 U2 29 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1070-9878 J9 IEEE T DIELECT EL IN JI IEEE Trns. Dielectr. Electr. Insul. PD JUN PY 2012 VL 19 IS 3 BP 990 EP 995 PG 6 WC Engineering, Electrical & Electronic; Physics, Applied SC Engineering; Physics GA 963FW UT WOS:000305606600029 ER PT J AU McQueary, CN Kirkup, BC Si, YZ Barlow, M Actis, LA Craft, DW Zurawskii, DV AF McQueary, Christin N. Kirkup, Benjamin C. Si, Yuanzheng Barlow, Miriam Actis, Luis A. Craft, David W. Zurawskii, Daniel V. TI Extracellular Stress and Lipopolysaccharide Modulate Acinetobacter baumannii Surface-Associated Motility SO JOURNAL OF MICROBIOLOGY LA English DT Article DE motility; LPS; swarming; biofilm; nosocomial pathogen; extracellular stressors; bacteria; optical mapping ID ENTERICA SEROVAR TYPHIMURIUM; GRAM-NEGATIVE BACTERIA; INTENSIVE-CARE-UNIT; BIOFILM FORMATION; PSEUDOMONAS-AERUGINOSA; SWARMING MOTILITY; TWITCHING MOTILITY; ESCHERICHIA-COLI; EPITHELIAL-CELLS; OUTER-MEMBRANE AB Acinetobacter baumannii is a nosocomial bacterial pathogen, and infections attributed to this species are further complicated by a remarkable ability to acquire antimicrobial resistance genes and to survive in a desiccated state. While the antibiotic resistance and biofilm formation of A. baumannii is well-documented, less is known about the virulence attributes of this organism. Recent studies reported A. baumannii strains display a motility phenotype, which appears to be partially dependent upon Type IV pill, autoinducer molecules, and the response to blue light. In this study, we wanted to determine the prevalence of this trait in genetically diverse clinical isolates, and any additional required factors, and environmental cues that regulate motility. When strains are subjected to a wide array of stress conditions, A. baumannii motility is significantly reduced. In contrast, when extracellular iron is provided or salinity is reduced, motility is significantly enhanced. We further investigated whether the genes required for the production of lipopolysaccharide (lpsB) and K1 capsule (epsA/ptk) are required for motility as demonstrated in other Gram-negative bacteria. Transposon mutagenesis resulted in reduced motility by the insertion derivatives of each of these genes. The presence of the parental allele provided in trans, in the insertion mutant background, could only restore motility in the lpsB mutant. The production of core LPS directly contributes to the motility phenotype, while capsular polysaccharide may have an indirect effect. Further, the data suggest motility is regulated by extracellular conditions, indicating that A. baumannii is actively sensing the environment and responding accordingly. C1 [McQueary, Christin N.; Kirkup, Benjamin C.; Si, Yuanzheng; Craft, David W.; Zurawskii, Daniel V.] Walter Reed Army Inst Res, Div Bacterial & Rickettsial Dis, Dept Wound Infect, Silver Spring, MD 20910 USA. [Kirkup, Benjamin C.] Uniformed Serv Univ Hlth Sci, F Edward Hebert Sch Med, Dept Med, Div Infect Dis, Merced, CA 95343 USA. [Barlow, Miriam] Univ Calif, Sch Nat Sci, Merced, CA 95343 USA. [Actis, Luis A.] Miami Univ, Dept Microbiol, Oxford, OH 45056 USA. RP Zurawskii, DV (reprint author), Walter Reed Army Inst Res, Div Bacterial & Rickettsial Dis, Dept Wound Infect, Silver Spring, MD 20910 USA. EM daniel.zurawski@amedd.army.mil RI Kirkup, Benjamin/C-3610-2009; OI Kirkup, Benjamin/0000-0002-8722-6218; Zurawski, Daniel/0000-0002-7920-5601 FU Defense Medical Research and Development Program (DMRDP) FX We would like to thank Anthony Campagnari for the strains he provided and for his review and critique of this manuscript. We would also like to thank the MRSN, Robert Bonomo, Xiaozhe Huang, and Marcelo Tolmasky for providing Acinetobacter baumannii strains. We would like to gratefully acknowledge the funds from the Defense Medical Research and Development Program (DMRDP) that supported this work. NR 87 TC 14 Z9 14 U1 0 U2 14 PU MICROBIOLOGICAL SOCIETY KOREA PI SEOUL PA KOREA SCIENCE & TECHNOLOGY CENTER 803, 635-4 YEOGSAM-DONG, KANGNAM-KU, SEOUL 135-703, SOUTH KOREA SN 1225-8873 J9 J MICROBIOL JI J. Microbiol. PD JUN PY 2012 VL 50 IS 3 BP 434 EP 443 DI 10.1007/s12275-012-1555-1 PG 10 WC Microbiology SC Microbiology GA 966PF UT WOS:000305849200010 PM 22752907 ER PT J AU Skovira, JW Shih, TM McDonough, JH AF Skovira, Jacob W. Shih, Tsung-Ming McDonough, John H. TI Neuropharmacological specificity of brain structures involved in soman-induced seizures SO NEUROTOXICOLOGY LA English DT Article DE Nerve agents; Soman; Seizures; Brain areas; Anticonvulsant; Scopolamine; Midazolam; MK-801; Rats ID LIMBIC STATUS EPILEPTICUS; FUNCTIONAL-ANATOMY; PERIRHINAL CORTEX; THALAMIC NUCLEUS; AREA TEMPESTAS; NERVE AGENTS; RATS; NEUROPATHOLOGY; INDUCTION; EPILEPSY AB Pharmacological control of seizure activity following nerve agent exposure is critical in reducing neuropathology and improving survival in casualties. Three classes of drugs, anticholinergics, benzodiazepines and excitatory amino acid (EM) antagonists, have been shown to be effective at moderating nerve agent-induced seizures. However, little is known about which brain structures are involved in producing the anticonvulsant response. This study evaluated drugs from each class, injected directly into one of three specific brain structures, the perirhinal cortex, the entorhinal cortex, or the mediodorsal thalamus, for their ability to modulate seizures induced by the nerve agent soman. The drugs evaluated were the anticholinergic scopolamine, the benzodiazepine midazolam, and the EM antagonist MK-801. For each drug treatment in each brain area, anticonvulsant ED50 values were calculated using an up-down dosing procedure over successive animals. There was no statistical difference in the anticonvulsant ED50 values for scopolamine and MK-801 in the perirhinal and entorhinal cortices. MK-801 pretreatment in the mediodorsal thalamus had a significantly lower anticonvulsant ED50 value than any other treatment/injection site combination. Midazolam required significantly higher doses than scopolamine and MK-801 in the perirhinal and entorhinal cortices to produce an anticonvulsant response and was ineffective in the mediodorsal thalamus. These findings support the contention that specific neuroanatomical pathways are activated during nerve agent-induced seizures and that the discrete brain structures involved have unique pharmacological thresholds for producing an anticonvulsant response. This study is also the first to show the involvement of the mediodorsal thalamus in the control of nerve agent-induced seizures. Published by Elsevier Inc. C1 [McDonough, John H.] USA, Pharmacol Branch, Div Res, Med Res Inst Chem Def,ATTN MCMR CDR P Dr JH McDon, Aberdeen Proving Ground, MD 21010 USA. RP McDonough, JH (reprint author), USA, Pharmacol Branch, Div Res, Med Res Inst Chem Def,ATTN MCMR CDR P Dr JH McDon, 3100 Ricketts Point Rd, Aberdeen Proving Ground, MD 21010 USA. EM john.mcdonough1@us.army.mil FU Army In-House Laboratory Independent Research (ILIR) FX The authors wish to recognize the excellent technical assistance of Ms. Jessica Chandler, Ms. Lindsey Newman, Ms. Sarah Cassella, Ms. Nicole Schlau, and Ms. Kerry Van Shura. This research was supported by the Army In-House Laboratory Independent Research (ILIR) program. NR 42 TC 9 Z9 10 U1 0 U2 6 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0161-813X J9 NEUROTOXICOLOGY JI Neurotoxicology PD JUN PY 2012 VL 33 IS 3 BP 463 EP 468 DI 10.1016/j.neuro.2012.03.006 PG 6 WC Neurosciences; Pharmacology & Pharmacy; Toxicology SC Neurosciences & Neurology; Pharmacology & Pharmacy; Toxicology GA 951OO UT WOS:000304730100023 PM 22774227 ER PT J AU Rossetti, F Furtado, MD Pak, T Bailey, K Shields, M Chanda, S Addis, M Robertson, BD Moffett, M Lumley, LA Yourick, DL AF Rossetti, Franco Furtado, Marcio de Araujo Pak, Thomas Bailey, Keenan Shields, Mallory Chanda, Soma Addis, Michael Robertson, Benjamin D. Moffett, Mark Lumley, Lucille A. Yourick, Debra L. TI Combined diazepam and HDAC inhibitor treatment protects against seizures and neuronal damage caused by soman exposure SO NEUROTOXICOLOGY LA English DT Article DE Suberoylanilide hydroxamic acid; Valproic acid; Fluoro-Jade B; Hippocampus; Amygdala; Thalamus; Piriform; Cortex; Soman ID SUBEROYLANILIDE HYDROXAMIC ACID; HISTONE DEACETYLASE INHIBITORS; CONVULSIVE STATUS EPILEPTICUS; TEMPORAL-LOBE EPILEPSY; VALPROIC ACID; INDUCED NEUROPATHOLOGY; BRAIN-DAMAGE; PHARMACOLOGICAL AGENTS; ANTIEPILEPTIC DRUGS; RECURRENT SEIZURES AB The occurrence of status epilepticus (SE) is considered the main cause of brain lesions and morphological alterations, such as hippocampal neuron loss, that result in chronic epilepsy. Previous work demonstrated the convulsive and widespread neuropathological effects of soman, an organophosphorus compound that causes SE and severe recurrent seizures as a result of exposure. Seizures begin rapidly after exposure, can continue for hours, and contribute to prolonged physical incapacitation of the victim. This study attempts to identify anticonvulsive and neuroprotective drugs against soman exposure. Male Sprague-Dawley rats were exposed to 1.0 LD50 soman. EEGraphical and neuropathological (Fluoro-Jade B staining) effects were analyzed at 72 h post-exposure to soman and subsequent treatments with diazepam (DZP) alone or in combination with histone deacetylase inhibitors, suberoylanilide hydroxamic acid (SAHA) or valproic acid (VPA). The extent of brain damage was dependent on the length of SE and not on the number of recurrent seizures. DZP treatment alone decreased SE time and damage in hippocampus, amygdala, thalamus and cortex, but not in piriform nuclei. The combination of DZP and VPA 100 mg/kg showed more anticonvulsive effects, decreased SE time, and afforded more neuroprotection in the hippocampus, mainly the ventral portion. The combination DZP and SAHA 25 mg/kg was more neuroprotective, but not more anticonvulsant than DZP alone. The DZP combination with VPA HDAC inhibitor proved to be a good treatment for SE and neuronal damage caused by soman exposure. Published by Elsevier Inc. C1 [Rossetti, Franco; Furtado, Marcio de Araujo; Pak, Thomas; Bailey, Keenan; Shields, Mallory; Chanda, Soma; Addis, Michael; Robertson, Benjamin D.; Yourick, Debra L.] Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. [Moffett, Mark; Lumley, Lucille A.] USA, Med Inst Chem Def, Analyt Toxicol Div, Aberdeen Proving Ground, MD USA. RP Yourick, DL (reprint author), Walter Reed Army Inst Res, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM debra.yourick@us.army.mil RI Yourick, Debra/A-2121-2011; Bailey, Keenan/E-5222-2012 FU National Research Council; Defense Threat Reduction Agency [I. E0042-08-WR-C] FX Dr. Franco Rossetti and Dr. Marcia de Araujo Furtado (currently at Clinical RM, Inc.) were administratively supported by National Research Council fellowships. The present study was supported financially by the Defense Threat Reduction Agency (Grant I. E0042-08-WR-C, Principal Investigator: Dr. Debra Yourick). Thanks to Dr. Taiza H. Figueiredo and Dr. Maria F.M. Braga from Uniformed Services University of the Health Sciences, Bethesda, MD, USA for Fluoro-Jade B technical assistance and Dr. Laurence Tong and Dr. Richard Bauman for assistance with microscopy. NR 84 TC 11 Z9 12 U1 0 U2 2 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0161-813X J9 NEUROTOXICOLOGY JI Neurotoxicology PD JUN PY 2012 VL 33 IS 3 BP 500 EP 511 DI 10.1016/j.neuro.2012.02.010 PG 12 WC Neurosciences; Pharmacology & Pharmacy; Toxicology SC Neurosciences & Neurology; Pharmacology & Pharmacy; Toxicology GA 951OO UT WOS:000304730100028 PM 22387230 ER PT J AU Helm, SR AF Helm, Steven R. TI Addendum to a Calculation of Expected Plant Frequency SO CASTANEA LA English DT Article C1 US Army Corps Engineers, Portland, OR 97208 USA. RP Helm, SR (reprint author), US Army Corps Engineers, POB 2946 CENWP PM E, Portland, OR 97208 USA. EM steve.r.helm@usace.army.mil NR 2 TC 0 Z9 0 U1 0 U2 2 PU SOUTHERN APPALACHIAN BOTANICAL SOC, NEWBERRY COLL PI NEWBERRY PA DEPT BIOLOGY, C/O CHARLES N HORN, SECRETARY-TREASURER, 2100 COLLEGE ST, NEWBERRY, SC 29108 USA SN 0008-7475 J9 CASTANEA JI Castanea PD JUN PY 2012 VL 77 IS 2 BP 158 EP 158 DI 10.2179/11-047 PG 1 WC Plant Sciences SC Plant Sciences GA 962KX UT WOS:000305545100004 ER PT J AU Davis, KL AF Davis, Konrad L. TI Tetracaine's Bad Reputation Is Not Well Deserved SO CHEST LA English DT Letter ID FIBEROPTIC BRONCHOSCOPY; COMPLICATIONS C1 Tripler Army Med Ctr, Dept Med, Honolulu, HI 96859 USA. RP Davis, KL (reprint author), Tripler Army Med Ctr, Dept Med, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM konrad_davis@yahoo.com NR 7 TC 0 Z9 0 U1 0 U2 0 PU AMER COLL CHEST PHYSICIANS PI NORTHBROOK PA 3300 DUNDEE ROAD, NORTHBROOK, IL 60062-2348 USA SN 0012-3692 J9 CHEST JI Chest PD JUN PY 2012 VL 141 IS 6 BP 1640 EP 1641 DI 10.1378/chest.12-0153 PG 2 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA 955RT UT WOS:000305039300047 PM 22670032 ER PT J AU Nakamura, YK Dubick, MA Omaye, ST AF Nakamura, Yukiko K. Dubick, Michael A. Omaye, Stanley T. TI Modulation of oxidative stress by gamma-glutamylcysteine (GGC) and conjugated linoleic acid (CLA) isomer mixture in human umbilical vein endothelial cells SO FOOD AND CHEMICAL TOXICOLOGY LA English DT Article DE gamma-Glutamylcysteine; Glutathione; Conjugated linoleic acid; Oxidative stress ID GLUTATHIONE SYNTHETASE; GENE-EXPRESSION; FATTY-ACIDS; PPAR-GAMMA; MECHANISMS; INJURY; ACCUMULATION; SUPPRESSION; DISEASES; HEALTH AB Individually, gamma-glutamylcysteine (GGC), a dipeptide and precursor of glutathione (GSH), and conjugated linoleic acid (CLA), a trans-fatty acid, exhibit antioxidant properties. The objective of this study was to compare effects of co-administration of GGC and CLA to treatment with GGC alone on oxidative stress and GSH synthesis in human endothelial cells. Changes in levels of 8-epi-PGF2 alpha, thiobarbituric acid reactive substances (TBARS), GSH, total antioxidants, GSH synthetase (GSS) expression, and transcription factor DNA binding were assessed in human umbilical vein endothelial cells (HUVEC) treated with GGC alone (100 mu mol/L) or combined with CLA isomer mixture (10, 50, 100 mu mol/L) for 24 h. Significantly higher levels of TBARS, 8-epi-PGF2 alpha, GSH, and GSS protein were found in cells treated with GGC and 10 mu mol/L CLA, compared to cells treated with GGC alone, indicative of prooxidant effects of CLA. Approximately 40% cell death was microscopically observed in cells incubated with GGC and 100 mu mol/L CLA. Despite lower levels of GSH, treatment with GGC and 50 mu mol/L CLA appeared to be protective from oxidative stress similar to treatment with GGC alone, as indicated by lower levels of TBARS, compared to control cells not treated with GGC and CLA. Published by Elsevier Ltd. C1 [Nakamura, Yukiko K.; Omaye, Stanley T.] Univ Nevada, Dept Nutr, Reno, NV 89557 USA. [Dubick, Michael A.] USA, Inst Surg Res, San Antonio, TX 78234 USA. RP Omaye, ST (reprint author), 1664 N Virginia St, Reno, NV 89557 USA. EM omaye@cabnr.unr.edu FU U.S. Army [USAMRMC09070005] FX This work was supported by federal funds from U.S. Army (USAMRMC09070005). NR 39 TC 2 Z9 2 U1 0 U2 6 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0278-6915 J9 FOOD CHEM TOXICOL JI Food Chem. Toxicol. PD JUN PY 2012 VL 50 IS 6 BP 1854 EP 1859 DI 10.1016/j.fct.2012.03.066 PG 6 WC Food Science & Technology; Toxicology SC Food Science & Technology; Toxicology GA 964TN UT WOS:000305719700006 PM 22490668 ER PT J AU Liu, RF Liu, J Tawa, G Wallqvist, A AF Liu, Ruifeng Liu, Jin Tawa, Greg Wallqvist, Anders TI 2D SMARTCyp Reactivity-Based Site of Metabolism Prediction for Major Drug-Metabolizing Cytochrome P450 Enzymes SO JOURNAL OF CHEMICAL INFORMATION AND MODELING LA English DT Article ID SUBSTRATE-BINDING; DOCKING; CYP2C9; P450; IDENTIFICATION; PHARMACOPHORE; ADAPTATIONS; ISOENZYMES; RESOLUTION; OXIDATION AB Cytochrome P450 (CYP) 3A4, 2D6, 2C9, 2C19, and 1A2 are the most important drug-metabolizing enzymes in the human liver. Knowledge of which parts of a drug molecule are subject to metabolic reactions catalyzed by these enzymes is crucial for rational drug design to mitigate ADME/toxicity issues. SMARTCyp, a recently developed 2D ligand structure-based method, is able to predict site-specific metabolic reactivity of CYP3A4 and CYP2D6 substrates with an accuracy that rivals the best and more computationally demanding 3D structure-based methods. In this article, the SM.ARTCyp approach was extended to predict the metabolic hotspots for CYP2C9, CYP2C19, and CYP1A2 substrates. This was accomplished by taking into account the impact of a key substrate-receptor recognition feature of each enzyme as a correction term to the SMARTCyp reactivity. The corrected reactivity was then used to rank order the likely sites of CYP-mediated metabolic reactions. For 60 CYP1A2 substrates, the observed major sites of CYP1A2 catalyzed metabolic reactions were among the top-ranked 1, 2, and 3 positions in 67%, 80%, and 83% of the cases, respectively. The results were similar to those obtained by MetaSite and the reactivity + docking approach. For 70 CYP2C9 substrates, the observed sites of CYP2C9 metabolism were among the top-ranked 1, 2, and 3 positions in 66%, 86%, and 87% of the cases, respectively. These results were better than the corresponding results of StarDrop version 5.0, which were 61%, 73%, and 77%, respectively. For 36 compounds metabolized by CYP2C19, the observed sites of metabolism were found to be among the top-ranked 1, 2, and 3 sites in 78%, 89%, and 94% of the cases, respectively. The computational procedure was implemented as an extension to the program SMARTCyp 2.0. With the extension, the program can now predict the site of metabolism for all five major drug-metabolizing enzymes with an accuracy similar to or better than that achieved by the best 3D structure-based methods. Both the Java source code and the binary executable of the program are freely available to interested users. C1 [Liu, Ruifeng; Liu, Jin; Tawa, Greg; Wallqvist, Anders] USA, DoD Biotechnol High Performance Comp Software App, Telemed & Adv Technol Res Ctr, Med Res & Mat Command, Ft Detrick, MD 21702 USA. RP Liu, RF (reprint author), USA, DoD Biotechnol High Performance Comp Software App, Telemed & Adv Technol Res Ctr, Med Res & Mat Command, Ft Detrick, MD 21702 USA. EM rliu@bhsai.org OI wallqvist, anders/0000-0002-9775-7469 FU U.S. Department of Defense Threat Reduction Agency [TMTI0004_09_BH_T] FX Funding of this research was provided by the U.S. Department of Defense Threat Reduction Agency Grant TMTI0004_09_BH_T. The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the U.S. Army or of the U.S. Department of Defense. We thank Mr. Li Chen and Jason Smith for their technical assistance. This paper has been approved for public release with unlimited distribution. NR 45 TC 17 Z9 18 U1 2 U2 26 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1549-9596 J9 J CHEM INF MODEL JI J. Chem Inf. Model. PD JUN PY 2012 VL 52 IS 6 BP 1698 EP 1712 DI 10.1021/ci3001524 PG 15 WC Chemistry, Medicinal; Chemistry, Multidisciplinary; Computer Science, Information Systems; Computer Science, Interdisciplinary Applications SC Pharmacology & Pharmacy; Chemistry; Computer Science GA 962YU UT WOS:000305588100021 PM 22631565 ER PT J AU Duan, JJ Oppel, C AF Duan, Jian J. Oppel, Craig TI Critical Rearing Parameters of Tetrastichus planipennisi (Hymenoptera: Eulophidae) as Affected by Host Plant Substrate and Host-Parasitoid Group Structure SO JOURNAL OF ECONOMIC ENTOMOLOGY LA English DT Article DE Tetrastichus planipennisi; Agrilus planipennis; Eulophidae; parasitoid; fitness ID ASH BORER COLEOPTERA; AGRILI HYMENOPTERA; NATURAL ENEMIES; FRUIT-FLIES; BUPRESTIDAE; BRACONIDAE; BEHAVIOR; ENCYRTIDAE; QUALITY; CHINA AB In laboratory assays, we evaluated the potential impact of host plant substrate types, host-parasitoid group sizes (densities), and parasitoid-to-host ratios on select fitness parameters of the larval endoparasitoid Tetrastichus planipennisi Yang (Hymenoptera: Eulophidae), newly introduced for biological control of emerald ash borer, Agrilus planipennis Fairmaire (Coleoptera: Buprestidae), in the United States. Results from our study showed that offspring production and critical fitness parameters (body size and sex ratio) of T. planipennisi from parasitized emerald ash borer larvae are significantly influenced by host plant substrate type, host-parasitoid group size, parasitoid-to-host ratio, or a combination in the primary exposure assay. The number of both female and male T. planipennisi progeny was significantly greater when emerald ash borer larvae were inserted into tropical ash [Fraxinus uhdei (Wenz.) Lingelsh.] logs rather than green ash (Fraxinus pensylvanica Marshall). When maintained at a constant 1:1 parasitoid-to-host ratio, assays with larger host-parasitoid group sizes (3:3-12:12) produced significantly greater numbers of both male and female offspring per parental wasp compared with those with the single host-parasitoid (1:1) group treatment. As the parasitoid-to-host ratio increased from 1:1 to 8:1 in the assay, the average brood size (number of offspring per parasitized emerald ash borer larva) increased significantly, whereas the average brood sex ratio (female to male) changed from being female-biased (6:1) to male-biased (1:2); body size of female offspring as measured by the length of ovipositor and left hind tibia also was reduced significantly. Based on these findings, we suggest that the current method of rearing T. planipennisi with artificially infested-emerald ash borer larvae use the tropical ash logs for emerald ash borer insertion, a larger (>= 3:3) host-parasitoid group size and 1:1 parasitoid-to-host ratio in the primary parasitoid exposure assays. C1 [Duan, Jian J.; Oppel, Craig] USA, Med Res Inst Chem Def, Edgewood, MD 21040 USA. RP Duan, JJ (reprint author), USA, Med Res Inst Chem Def, Edgewood, MD 21040 USA. EM jian.duan@ars.usda.com NR 31 TC 12 Z9 14 U1 1 U2 24 PU ENTOMOLOGICAL SOC AMER PI LANHAM PA 10001 DEREKWOOD LANE, STE 100, LANHAM, MD 20706-4876 USA SN 0022-0493 J9 J ECON ENTOMOL JI J. Econ. Entomol. PD JUN PY 2012 VL 105 IS 3 BP 792 EP 801 DI 10.1603/EC11431 PG 10 WC Entomology SC Entomology GA 961NY UT WOS:000305473500006 PM 22812114 ER PT J AU Driggers, RG Vollmerhausen, R Reynolds, JP Fanning, J Holst, GC AF Driggers, Ronald G. Vollmerhausen, Richard Reynolds, Joseph P. Fanning, Jonathan Holst, Gerald C. TI Infrared detector size: how low should you go? SO OPTICAL ENGINEERING LA English DT Article DE infrared systems; imaging; performance AB In the past five years, significant progress has been accomplished in the reduction of infrared detector pitch and detector size. Recently, longwave infrared (LWIR) detectors in limited quantities have been fabricated with a detector pitch of 5 mu m. Detectors with 12-mu m pitch are now becoming standard in both midwave infrared (MWIR) and LWIR sensors. Persistent surveillance systems are pursuing 10-mu m detector pitch in large format arrays. The fundamental question that most system designers and detector developers desire an answer to is: "How small can you produce an infrared detector and still provide value in performance?" If a system is mostly diffraction-limited, then developing a smaller detector is of limited benefit. If a detector is so small that it does not collect enough photons to produce a good image, then a smaller detector is not much benefit. Resolution and signal-to-noise are the primary characteristics of an imaging system that contribute to targeting, pilotage, search, and other human warfighting task performance. We investigate the task of target discrimination range performance as a function of detector size/pitch. Results for LWIR and MWIR detectors are provided and depend on a large number of assumptions that are reasonable. (C) 2012 Society of Photo-Optical Instrumentation Engineers (SPIE). [DOI: 10.1117/1.OE.51.6.063202] C1 [Driggers, Ronald G.] USN, Res Lab, Code Opt Sci Div 5600, Washington, DC 20375 USA. [Driggers, Ronald G.] USN, Res Lab, Div Opt Sci, Senior Execut Serv, Washington, DC 20375 USA. [Vollmerhausen, Richard] Univ Delaware, Dept Elect Engn, Newark, DE 19716 USA. [Reynolds, Joseph P.; Fanning, Jonathan] USA, Night Vis & Elect Sensors Directorate, Ft Belvoir, VA 22060 USA. RP Driggers, RG (reprint author), USN, Res Lab, Code Opt Sci Div 5600, 4555 Overlook Ave, Washington, DC 20375 USA. EM ronald.driggers@nrl.navy.mil NR 9 TC 22 Z9 25 U1 1 U2 10 PU SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98225 USA SN 0091-3286 J9 OPT ENG JI Opt. Eng. PD JUN PY 2012 VL 51 IS 6 AR 063202 DI 10.1117/1.OE.51.6.063202 PG 6 WC Optics SC Optics GA 965UG UT WOS:000305792200012 ER PT J AU Lapchak, PH Kannan, L Rani, P Pamuk, ON Ioannou, A Lucca, JJD Pine, P Tsokos, GC AF Lapchak, Peter H. Kannan, Lakshmi Rani, Poonam Pamuk, Omer Nuri Ioannou, Antonis Lucca, Jurandir J. Dalle Pine, Polly Tsokos, George C. TI Inhibition of Syk activity by R788 in platelets prevents remote lung tissue damage after mesenteric ischemia-reperfusion injury SO AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY LA English DT Article DE lungs; tissue injury; intestine; platelet depletion; platelet transfusion ID SPLEEN TYROSINE KINASE; ENDOTHELIAL-CELLS; LEUKOCYTE INTERACTIONS; FUNCTIONAL EXPRESSION; CD40 LIGAND; COMPLEMENT; ACTIVATION; DISEASE; STROKE; ISCHEMIA/REPERFUSION AB Lapchak PH, Kannan L, Rani P, Pamuk ON, Ioannou A, Lucca JJ, Pine P, Tsokos GC. Inhibition of Syk activity by R788 in platelets prevents remote lung tissue damage after mesenteric ischemia-reperfusion injury. Am J Physiol Gastrointest Liver Physiol 302: G1416-G1422, 2012. First published April 5, 2012; doi: 10.1152/ajpgi.00026.2012.-Tissue injury following ischemia-reperfusion (I/R) occurs as a consequence of actions of soluble factors and immune cells. Growing evidence supports a role for platelets in the manifestation of tissue damage following I/R. Spleen tyrosine kinase has been well documented to be important in lymphocyte activation and more recently in platelet activation. We performed experiments to evaluate whether inhibition of platelet activation through inhibition of spleen tyrosine kinase prevents tissue damage after mesenteric I/R injury. Platelets isolated from C57BL/6J mice fed with R788 for 10 days were transfused into C57BL/6J mice depleted of platelets 2 days before mesenteric I/R injury. Platelet-depleted mice transfused with platelets from R788-treated mice before mesenteric I/R displayed a significant reduction in the degree of remote lung damage, but with little change in the degree of local intestinal damage compared with control I/R mice. Transfusion of R788-treated platelets also decreased platelet sequestration, C3 deposition, and immunoglobulin deposition in lung, but not in the intestine, compared with control groups. These findings demonstrate that platelet activation is a requisite for sequestration in the pulmonary vasculature to mediate remote tissue injury after mesenteric I/R. The use of small-molecule inhibitors may be valuable to prevent tissue damage in remote organs following I/R injury. C1 [Tsokos, George C.] Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Div Rheumatol,Dept Med, Boston, MA 02115 USA. [Pamuk, Omer Nuri] Trakya Univ, Sch Med, Div Rheumatol, Edirne, Turkey. [Lucca, Jurandir J. Dalle] USA, Inst Surg Res, San Antonio, TX USA. [Pine, Polly] Rigel Pharmaceut, San Francisco, CA USA. RP Tsokos, GC (reprint author), Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Div Rheumatol,Dept Med, 330 Brookline Ave,CLS 928, Boston, MA 02115 USA. EM gtsokos@bidmc.harvard.edu RI Ji, Haofeng/G-6206-2012; OI Lapchak, Peter/0000-0001-8597-088X FU Medical Research and Material Command of the Department of the Army [W81XWH-09-1-0530, W81XWH-09-1-0536] FX The research presented herein was supported by Grant nos. W81XWH-09-1-0530 and W81XWH-09-1-0536 from Medical Research and Material Command of the Department of the Army. NR 50 TC 6 Z9 6 U1 0 U2 4 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 0193-1857 J9 AM J PHYSIOL-GASTR L JI Am. J. Physiol.-Gastroint. Liver Physiol. PD JUN PY 2012 VL 302 IS 12 BP G1416 EP G1422 DI 10.1152/ajpgi.00026.2012 PG 7 WC Gastroenterology & Hepatology; Physiology SC Gastroenterology & Hepatology; Physiology GA 960OU UT WOS:000305398600007 PM 22492694 ER PT J AU Blakey, BL Gratrix, ML AF Blakey, Brittony L. Gratrix, Max L. TI Reactive Benign Follicular Mucinosis: A Report of 2 Cases SO CUTIS LA English DT Article ID ASSOCIATION AB We report 2 cases of adolescents who developed follicular mucinosis following cutaneous infections. A 17-year-old adolescent boy was evaluated for a 2-week history of erythematous papules and plaques on his face and neck. One month prior to presentation a culture was taken that was positive for methicillin-sensitive Staphylococcus aureus-associated impetigo. Biopsies from 2 representative lesions demonstrated follicular mucinosis without evidence of folliculotropism or T cell gene rearrangements. A separate case involved a 17-year-old adolescent girl who presented with an edematous plaque on her right preauricular region and scattered erythematous papules and small annular plaques over her face 2 weeks following a herpes simplex virus type 2 (HHV-2) infection on her face. Biopsy showed follicular mucinosis without evidence of epidermotropism or lymphocyte atypia. There was no herpesvirus cytopathic effect. The first case rapidly responded to an oral prednisone taper and the second case resolved over several weeks without further treatment. Cutis. 2012;89:266-268. C1 [Blakey, Brittony L.; Gratrix, Max L.] Walter Reed Army Med Ctr, Dept Dermatol, Washington, DC 20307 USA. RP Gratrix, ML (reprint author), Walter Reed Army Med Ctr, Dept Dermatol, 6900 Georgia Ave NW, Washington, DC 20307 USA. EM max.gratrix@us.army.mil NR 11 TC 5 Z9 5 U1 0 U2 0 PU QUADRANT HEALTHCOM INC PI PARSIPPANY PA 7 CENTURY DRIVE, STE 302, PARSIPPANY, NJ 07054-4603 USA SN 0011-4162 J9 CUTIS JI Cutis PD JUN PY 2012 VL 89 IS 6 BP 266 EP 268 PG 3 WC Dermatology SC Dermatology GA 962ZG UT WOS:000305589300004 PM 22838088 ER PT J AU Cunningham, SE Johnson, MD Laczek, JT AF Cunningham, Scott E. Johnson, Mark D. Laczek, Jeffrey T. TI Lymphogranuloma venereum proctitis SO GASTROINTESTINAL ENDOSCOPY LA English DT Editorial Material C1 [Cunningham, Scott E.] Tripler Army Med Ctr, Dept Internal Med, Honolulu, HI 96859 USA. [Johnson, Mark D.] Naval Med Ctr San Diego, Div Infect Dis, San Diego, CA USA. [Laczek, Jeffrey T.] Tripler Army Med Ctr, Dept Gastroenterol, Honolulu, HI 96859 USA. RP Cunningham, SE (reprint author), Tripler Army Med Ctr, Dept Internal Med, Honolulu, HI 96859 USA. NR 0 TC 1 Z9 1 U1 1 U2 1 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0016-5107 J9 GASTROINTEST ENDOSC JI Gastrointest. Endosc. PD JUN PY 2012 VL 75 IS 6 BP 1269 EP 1270 DI 10.1016/j.gie.2012.01.041 PG 3 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 961HA UT WOS:000305453700027 PM 22459660 ER PT J AU Liu, LB Xie, H Albert, DG Eller, PR Cheng, JRC AF Liu, Lanbo Xie, Hao Albert, Donald G. Eller, Paul R. Cheng, Jing-Ru C. TI A SCENARIO STUDY FOR IMPROVING COST-EFFECTIVENESS IN ACOUSTIC TIME-REVERSAL SOURCE RELOCATION IN AN URBAN ENVIRONMENT SO JOURNAL OF COMPUTATIONAL ACOUSTICS LA English DT Article DE Finite difference time domain (FDTD); time-reversal (TR); urban acoustic source relocation; receiver array; scenarios; urban acoustic propagation ID PULSE-PROPAGATION; SOUND-PROPAGATION; BUILDINGS AB Through finite difference time domain (FDTD) numerical simulation, we have studied the possible observation settings to improve the cost effectiveness in time-reversal (TR) source relocation in a two-dimensional (2D) urban setting under a number of typical scenarios. All scenario studies were based on the FDTD computation of the acoustic wave field resulted from an impulse source, propagated through an artificial village composed of 15 buildings and a set of sources and receivers, a typical urban setting has been extensively analyzed in previous studies. The FDTD numerical modeling code can be executed on an off-the-shelf graphic processor unit (GPU) that increases the speed of the time-reversal calculations by a factor of 200. With this approach the computational results lead to some significant conclusions. In general, using only one non-line-of-sight (NLOS) single receiver is not enough to do a quality work to re-locate the source via time-reversal. This is particularly true when there are more than one path between the source and this receiver with similar wave energy travel time. However, when the single sensor is located in an acoustic channel, reverberation inside the waveguide may increase the effective aperture of the single receiver enough to give a good location. It is equivalent to say that the waveguide and the single receiver form a "virtual array". It appears that a sensor array with a minimum number of three receivers might be the most cost-effective way to carry out TR source relocation in an urban environment. The most optimal geometry of a sensor array with a minimum number of three receivers could be an equal side-length triangle. Simple analysis showed that by this setup it is possible to catch sound sources from almost all possible azimuths. Effective source relocation essentially depends on the geometry, relativity to the scatters, etc. of the sensing array. Generally, adding another single sensor relatively far away from the main array will not improve the results. It is practically useful and achievable to have a sensor array mounted on the outside of a single building, and in these cases successful source relocations were obtained. As stated by the fundamental TR theory, increasing the number of scatters, here, increasing the number of buildings will definitely be helpful to increase the effectiveness of TR source relocation. C1 [Liu, Lanbo; Xie, Hao] Univ Connecticut, Dept Civil & Environm Engn, Storrs, CT 06269 USA. [Liu, Lanbo; Albert, Donald G.] USA, Cold Reg Res & Engn Lab, Engineer Res & Dev Ctr, Hanover, NH 03755 USA. [Eller, Paul R.; Cheng, Jing-Ru C.] USA, Informat Technol Lab, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Liu, LB (reprint author), Univ Connecticut, Dept Civil & Environm Engn, 261 Glenbrook Rd U-2037, Storrs, CT 06269 USA. EM Lanbo.Liu@UConn.edu; Donald.G.Albert@usace.army.mil NR 22 TC 0 Z9 0 U1 1 U2 13 PU WORLD SCIENTIFIC PUBL CO PTE LTD PI SINGAPORE PA 5 TOH TUCK LINK, SINGAPORE 596224, SINGAPORE SN 0218-396X J9 J COMPUT ACOUST JI J. Comput. Acoust. PD JUN PY 2012 VL 20 IS 2 SI SI AR 1240003 DI 10.1142/S0218396X12400036 PG 16 WC Acoustics; Mathematics, Interdisciplinary Applications SC Acoustics; Mathematics GA 962JC UT WOS:000305539400004 ER PT J AU Butler, DK Simms, JE Furey, JS Bennett, HH AF Butler, Dwain K. Simms, Janet E. Furey, John S. Bennett, Hollis H. TI Review of Magnetic Modeling for UXO and Applications to Small Items and Close Distances SO JOURNAL OF ENVIRONMENTAL AND ENGINEERING GEOPHYSICS LA English DT Review ID UNEXPLODED ORDNANCE AB Prior to 1990, UXO were generally modeled or approximated as compact, ferrous objects; the model was effectively a uniformly magnetized sphere of iron at a specified or an unknown distance from the magnetic sensor. Correlations were developed between various UXO, represented as compact masses of iron, and magnetic anomaly signature features such as maximum positive value, peak-to-peak value, and wavelength. The uniformly magnetized sphere, equivalent to a point dipole model external to the sphere, cannot account for magnetic phenomenology of actual UXO, which exist in forms ranging from approximately spherical to highly elongated, with elongations as large as 5 (ratio of length to diameter). UXO are generally ferrous, with large magnetic permeability, although some can contain aluminum or other non-magnetic metals. This paper reviews the phenomenology of models applied to simulation of UXO magnetic anomalies. The multipole expansion solution of the prolate spheroid model in earth's magnetic field is highlighted, as it replicates most of the phenomenology of UXO magnetic anomalies, and is about the most complicated model for which practical geophysical inversion can be achieved (8-parameter model vector, plus magnitude and orientation of the earth's magnetic field). While the prolate spheroid model works well for the larger UXO (e.g., 60-mm mortars and larger) at distances (burial depth plus sensor height) greater than the length of the target or model, it has not been tested for close distances (less than the target length) and for the smaller UXO (e.g., 20-mm to 40-mm projectiles). Test stand magnetic anomaly measurements for these small UXO at distances equal to the length or less from the sensor are compared to model calculations. The importance of including the octupole component is demonstrated for small ordnance at close distances, and the differences in modeling and inversion results for UXO physical dimension versus UXO ferrous component dimension are presented. C1 [Butler, Dwain K.] Appl Geophys Consultancy LLC, Vicksburg, MS 39180 USA. [Simms, Janet E.; Furey, John S.; Bennett, Hollis H.] USA, Engn Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Butler, DK (reprint author), Appl Geophys Consultancy LLC, 211 Grinders Pl, Vicksburg, MS 39180 USA. EM agc.llc@bellsouth.net FU U.S. Army Engineer Environmental Quality Technology Program at the U.S. Army Engineer Research and Development Center (ERDC), Vicksburg, MS FX This research was supported by the U.S. Army Engineer Environmental Quality Technology Program at the U.S. Army Engineer Research and Development Center (ERDC), Vicksburg, MS. NR 28 TC 1 Z9 1 U1 0 U2 4 PU ENVIRONMENTAL ENGINEERING GEOPHYSICAL SOC PI DENVER PA 1720 SOUTH BELLAIRE, STE 110, DENVER, CO 80222-433 USA SN 1083-1363 J9 J ENVIRON ENG GEOPH JI J. Environ. Eng. Geophys. PD JUN PY 2012 VL 17 IS 2 BP 53 EP 73 PG 21 WC Geochemistry & Geophysics; Engineering, Geological SC Geochemistry & Geophysics; Engineering GA 961EO UT WOS:000305447000001 ER PT J AU Siegel, CL Andreotti, RF Cardenes, HR Brown, DL Gaffney, DK Horowitz, NS Javitt, MC Lee, SI Mitchell, DG Moore, DH Rao, GG Royal, HD Small, W Varia, MA Yashar, CM AF Siegel, Cary Lynn Andreotti, Rochelle F. Cardenes, Higinia Rosa Brown, Douglas L. Gaffney, David K. Horowitz, Neil S. Javitt, Marcia C. Lee, Susanna I. Mitchell, Donald G. Moore, David H. Rao, Gautam G. Royal, Henry D. Small, William, Jr. Varia, Mahesh A. Yashar, Catheryn M. TI ACR Appropriateness Criteria (R) Pretreatment Planning of Invasive Cancer of the Cervix SO JOURNAL OF THE AMERICAN COLLEGE OF RADIOLOGY LA English DT Article DE Appropriateness Criteria; cervical cancer; imaging; invasive; pretreatment ID POSITRON-EMISSION-TOMOGRAPHY; LYMPH-NODE METASTASIS; SQUAMOUS-CELL CARCINOMA; CLINICAL STAGE-I; COMPUTED-TOMOGRAPHY; FDG-PET; INTEGRATED PET/CT; PREDICTIVE-VALUE; F-18-FDG PET; INTERGROUP AB The prognosis of cervical cancer is linked to lymph node involvement, and this is predicted clinically and pathologically by the stage of the disease, as well as the volume and grade of the tumor. Staging of cervical cancer based on International Federation of Gynecology and Obstetrics (FIGO) staging uses physical examination, cystoscopy, proctoscopy, intravenous urography, and barium enema. It does not include CT Of MRI. Evaluation of the parametrium is limited in FIGO staging, and lymph node metastasis, an important prognostic factor, is not included in FIGO staging. The most important role for imaging is to distinguish stages Ia, Ib, and ha disease treated with surgery from advanced disease treated with radiation therapy with or without chemotherapy. This article reviews the current role of imaging in pretreatment planning of invasive cervical cancer. The ACR Appropriateness Criteria (R) are evidence-based guidelines for specific clinical conditions that are reviewed every 2 years by a multidisciplinaty expert panel. The guideline development and review include an extensive analysis of current medical literature from peer-reviewed journals and the application of a well-established consensus methodology (modified Delphi) to rate the appropriateness of imaging and treatment procedures by the panel. In those instances in which evidence is lacking or not definitive, expert opinion may be used to recommend imaging or treatment. C1 [Siegel, Cary Lynn; Royal, Henry D.] Mallinckrodt Inst Radiol, St Louis, MO USA. [Andreotti, Rochelle F.] Vanderbilt Univ, Med Ctr, Nashville, TN USA. [Cardenes, Higinia Rosa] Indiana Univ, Med Ctr, Indianapolis, IN USA. [Brown, Douglas L.] Mayo Clin, Rochester, MN USA. [Gaffney, David K.] Univ Utah, Med Ctr, Salt Lake City, UT USA. [Horowitz, Neil S.] Brigham & Womens Hosp, Boston, MA 02115 USA. [Horowitz, Neil S.] Soc Gynecol Oncologists, Chicago, IL USA. [Javitt, Marcia C.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [Lee, Susanna I.] Massachusetts Gen Hosp, Boston, MA 02114 USA. [Mitchell, Donald G.] Thomas Jefferson Univ Hosp, Philadelphia, PA 19107 USA. [Moore, David H.] Indiana Univ Sch Med, Indianapolis, IN USA. [Moore, David H.] Amer Coll Obstetricians & Gynecologists, Washington, DC 20024 USA. [Rao, Gautam G.] Univ Maryland, Sch Med, Baltimore, MD 21201 USA. [Rao, Gautam G.] Amer Soc Clin Oncol, Alexandria, VA USA. [Royal, Henry D.] Soc Nucl Med, Reston, VA USA. [Small, William, Jr.] Northwestern Univ, Robert H Lurie Comprehens Canc Ctr, Chicago, IL 60611 USA. [Varia, Mahesh A.] Univ N Carolina Hosp, Chapel Hill, NC USA. [Yashar, Catheryn M.] Univ Calif San Diego, San Diego, CA 92103 USA. RP Siegel, CL (reprint author), Amer Coll Radiol, 1891 Preston White Dr, Reston, VA 20191 USA. EM siegelc@mir.wustl.edu NR 68 TC 15 Z9 16 U1 0 U2 3 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1546-1440 J9 J AM COLL RADIOL JI J. Am. Coll. Radiol. PD JUN PY 2012 VL 9 IS 6 BP 395 EP 402 DI 10.1016/j.jacr.2012.02.021 PG 8 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA 960BU UT WOS:000305363800009 PM 22632665 ER PT J AU Hale, DF Cannon, JW Batchinsky, AI Cancio, LC Aden, JK White, CE Renz, EM Blackbourne, LH Chung, KK AF Hale, Diane F. Cannon, Jeremy W. Batchinsky, Andriy I. Cancio, Leopoldo C. Aden, James K. White, Christopher E. Renz, Evan M. Blackbourne, Lorne H. Chung, Kevin K. TI Prone positioning improves oxygenation in adult burn patients with severe acute respiratory distress syndrome SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY LA English DT Article DE Burn; prone positioning; ARDS; inhalation injury; hypoxemia ID ACUTE LUNG INJURY; END-EXPIRATORY PRESSURE; INHALED NITRIC-OXIDE; MECHANICAL VENTILATION; METAANALYSIS; TRIAL; ARDS; SURVIVAL; FAILURE; VICTIMS AB BACKGROUND: Prone positioning (PP) improves oxygenation and may provide a benefit in patients with acute respiratory distress syndrome (ARDS). This approach adds significant challenges to patients in intensive care by limiting access to the endotracheal or tracheostomy tube and vascular access. PP also significantly complicates burn care by making skin protection and wound care more difficult. We hypothesize that PP improves oxygenation and can be performed safely in burn patients with ARDS. METHODS: PP was implemented in a burn intensive care unit for 18 patients with severe refractory ARDS. The characteristics of these patients were retrospectively reviewed to evaluate the impact of PP on Pao(2):FiO(2) ratio (PFR) during the first 48 hours of therapy. Each patient was considered his or her own control before initiation of PP, and trends in PFR were evaluated with one-way analysis of variance. Secondary measures of complications and mortality were also evaluated. RESULTS: Mean PFR before PP was 87 (+/- 38) with a mean sequential organ failure assessment score of 11 (+/- 4). PFR improved during 48 hours in 12 of 14 survivors (p < 0.05). Mean PFR was 133 (+/- 77) immediately after PP, 165 (+/- 118) at 6 hours, 170 (+/- 115) at 12 hours, 214 (+/- 126) at 24 hours, 236 (+/- 137) at 36 hours, and 210 (+/- 97) at 48 hours. At each measured time interval except the last, PFR significantly improved. There were no unintended extubations. Facial pressure ulcers developed in four patients (22%). Overall, 14 survived 48 hours (78%), 12 survived 28 days (67%), and six survived to hospital discharge (33%). CONCLUSIONS: PP improves oxygenation in burn patients with severe ARDS and was safely implemented in a burn intensive care unit. Mortality in this population remains high, warranting investigation into additional complementary rescue therapies. (J Trauma Acute Care Surg. 2012;72: 1634-1639. Copyright (C) 2012 by Lippincott Williams & Wilkins) LEVEL OF EVIDENCE: Therapeutic study, level IV. C1 [Hale, Diane F.; Cannon, Jeremy W.] Brooke Army Med Ctr, Dept Surg, Ft Sam Houston, TX 78234 USA. [Cannon, Jeremy W.; Renz, Evan M.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [Batchinsky, Andriy I.; Cancio, Leopoldo C.; Aden, James K.; White, Christopher E.; Renz, Evan M.; Blackbourne, Lorne H.; Chung, Kevin K.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Chung, KK (reprint author), USA, Inst Surg Res, 3698 Chambers Pass, San Antonio, TX 78234 USA. EM kevin.chung@amedd.army.mil FU Clinical Trials Task Area; United States Army Institute of Surgical Research FX Supported by the Clinical Trials Task Area, United States Army Institute of Surgical Research. NR 28 TC 16 Z9 18 U1 1 U2 13 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 2163-0755 J9 J TRAUMA ACUTE CARE JI J. Trauma Acute Care Surg. PD JUN PY 2012 VL 72 IS 6 BP 1634 EP 1639 DI 10.1097/TA.0b013e318247cd4f PG 6 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 960WH UT WOS:000305422900035 PM 22695433 ER PT J AU Wood, MD Britt, TW Wright, KM Thomas, JL Bliese, PD AF Wood, Michael D. Britt, Thomas W. Wright, Kathleen M. Thomas, Jeffrey L. Bliese, Paul D. TI Benefit Finding at War: A Matter of Time SO JOURNAL OF TRAUMATIC STRESS LA English DT Article ID MENTAL-HEALTH; RESILIENCE; EXPERIENCE; SOLDIERS; STRESS; GROWTH; IRAQ AB Benefit finding, described as one's ability to find benefits from stressful situations, has been hypothesized as a buffer against the negative effects of stress on mental health outcomes. Nonetheless, many have questioned the buffering potential of benefit finding in the face of prolonged and excessive stress such as is found in the combat environment. This study suggests that the length of a combat deployment and benefit finding may impact the relationship between combat exposure and posttraumatic stress disorder (PTSD) symptoms. Surveys were distributed to U.S. enlisted soldiers (n = 1,917), officers, and warrant officers (n = 163) of various combat and combat support units deployed to Iraq. A significant 3-way interaction (sr2 = .004, p < .05) revealed that benefit finding buffered soldiers from increased PTSD symptoms under high levels of combat exposure early in the deployment, but not in later months. These results indicate that although benefit finding may be a useful coping approach during the early phases of deployment, prolonged exposure to stress may diminish a soldier's ability to use benefit finding as a method for coping. C1 [Wood, Michael D.; Britt, Thomas W.; Wright, Kathleen M.] US Army, Med Res Unit Europe, Heidelberg, Germany. [Britt, Thomas W.; Thomas, Jeffrey L.; Bliese, Paul D.] Walter Reed Army Inst Res, Silver Spring, MD USA. RP Wood, MD (reprint author), USA, Med Res Unit Europe, CMR 442, APO, AE 09042 USA. EM michael.wood@amedd.army.mil NR 24 TC 2 Z9 2 U1 1 U2 5 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0894-9867 J9 J TRAUMA STRESS JI J. Trauma Stress PD JUN PY 2012 VL 25 IS 3 BP 307 EP 314 DI 10.1002/jts.21701 PG 8 WC Psychology, Clinical; Psychiatry SC Psychology; Psychiatry GA 962VV UT WOS:000305576500014 PM 22729980 ER PT J AU Owens, BD Tokish, J AF Owens, Brett D. Tokish, John TI Recurrent Anterior Shoulder Instability SO ORTHOPEDICS LA English DT Editorial Material ID HILL-SACHS REMPLISSAGE; LESION C1 [Owens, Brett D.] Keller Army Hosp, West Point, NY 10996 USA. [Tokish, John] Tripler Army Med Ctr, Honolulu, HI 96859 USA. RP Owens, BD (reprint author), Keller Army Hosp, West Point, NY 10996 USA. NR 5 TC 0 Z9 0 U1 0 U2 1 PU SLACK INC PI THOROFARE PA 6900 GROVE RD, THOROFARE, NJ 08086 USA SN 0147-7447 J9 ORTHOPEDICS JI Orthopedics PD JUN PY 2012 VL 35 IS 6 BP 496 EP 497 DI 10.3928/01477447-20120525-10 PG 2 WC Orthopedics SC Orthopedics GA 960YS UT WOS:000305430300047 PM 22691638 ER PT J AU Acevedo, JL Shah, RK Brietzke, SE AF Acevedo, Jason L. Shah, Rahul K. Brietzke, Scott E. TI Systematic Review of Complications of Tonsillotomy versus Tonsillectomy SO OTOLARYNGOLOGY-HEAD AND NECK SURGERY LA English DT Review DE tonsillotomy; partial tonsillectomy; sleep-disordered breathing; evidence-based medicine ID POWERED INTRACAPSULAR TONSILLECTOMY; QUALITY-OF-LIFE; MONOPOLAR ELECTROCAUTERY TONSILLECTOMY; RANDOMIZED CONTROLLED-TRIAL; RADIOFREQUENCY TONSILLOTOMY; DISSECTION TONSILLECTOMY; COBLATION TONSILLECTOMY; RECURRENT TONSILLITIS; CHILDREN; MICRODEBRIDER AB Objective. Intracapsular tonsillotomy continues to gain acceptance as an alternative to traditional tonsillectomy. Despite large clinical studies, there is a lack of consensus as to which technique offers lower complication rates. This study seeks to analyze the available data and surmise the complication rates of partial tonsillectomy as compared with traditional tonsillectomy. Data Sources. MEDLINE was searched using multiple search terms. Review Methods. After the MEDLINE search, the following inclusion criteria were applied: English language, human subjects, and related to partial tonsillectomy. Multiple tonsillotomy techniques were included. The results of these studies were summated and the results analyzed. Subgroup analysis was then performed. Results. Thirty-three studies met inclusion criteria. Tonsillotomy had a lower postoperative bleeding rate, lower postoperative dehydration rate requiring medical care, reduced days of analgesic use, and reduced days to return to normal diet compared with tonsillectomy. When separated into higher versus lower quality studies, the differences in bleeding and dehydration were negligible, while differences in return to diet and days of analgesic use persisted. Mean intraoperative blood loss was similar for both techniques. Insufficient data were available to assess tonsil regrowth rates. Conclusions. Tonsillotomy appears to be a safe technique that may offer some advantages over tonsillectomy in terms of postoperative morbidity, but differences in hemorrhage and dehydration were not evident in high-quality studies. Data regarding tonsil regrowth rates and efficacy in treating sleep-disordered breathing are not yet sufficient for formal analysis, which may preclude widespread acceptance of this technique. C1 [Acevedo, Jason L.] Reynolds Army Community Hosp, Ft Sill, OK 73505 USA. [Acevedo, Jason L.; Brietzke, Scott E.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [Shah, Rahul K.] Childrens Natl Med Ctr, Washington, DC 20010 USA. [Shah, Rahul K.] George Washington Univ, Washington, DC USA. [Brietzke, Scott E.] Walter Reed Natl Mil Med Ctr, Bethesda, MD USA. RP Acevedo, JL (reprint author), Reynolds Army Community Hosp, 4301 Wilson St, Ft Sill, OK 73505 USA. EM jasag00@yahoo.com NR 35 TC 25 Z9 27 U1 0 U2 8 PU SAGE PUBLICATIONS LTD PI LONDON PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND SN 0194-5998 J9 OTOLARYNG HEAD NECK JI Otolaryngol. Head Neck Surg. PD JUN PY 2012 VL 146 IS 6 BP 871 EP 879 DI 10.1177/0194599812439017 PG 9 WC Otorhinolaryngology; Surgery SC Otorhinolaryngology; Surgery GA 962EI UT WOS:000305522400001 PM 22394550 ER PT J AU Heiner, JD Kalsi, KS AF Heiner, Jason D. Kalsi, Kamaljeet S. TI IMAGES IN EMERGENCY MEDICINE Traumatic mydriasis with hyphema SO ANNALS OF EMERGENCY MEDICINE LA English DT Editorial Material C1 [Heiner, Jason D.] Brooke Army Med Ctr, Dept Emergency Med, Ft Sam Houston, TX 78234 USA. [Kalsi, Kamaljeet S.] Womack Army Med Ctr, Dept Emergency Med, Ft Bragg, NC USA. RP Heiner, JD (reprint author), Brooke Army Med Ctr, Dept Emergency Med, Ft Sam Houston, TX 78234 USA. NR 3 TC 1 Z9 1 U1 0 U2 0 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0196-0644 J9 ANN EMERG MED JI Ann. Emerg. Med. PD JUN PY 2012 VL 59 IS 6 BP 456 EP + DI 10.1016/j.annemergmed.2011.11.040 PG 2 WC Emergency Medicine SC Emergency Medicine GA 959HA UT WOS:000305302300003 PM 22626014 ER PT J AU Papa, L Lewis, LM Falk, JL Zhang, ZQ Silvestri, S Giordano, P Brophy, GM Demery, JA Dixit, NK Ferguson, I Liu, MC Mo, JX Akinyi, L Schmid, K Mondello, S Robertson, CS Tortella, FC Hayes, RL Wang, KKW AF Papa, Linda Lewis, Lawrence M. Falk, Jay L. Zhang, Zhiqun Silvestri, Salvatore Giordano, Philip Brophy, Gretchen M. Demery, Jason A. Dixit, Neha K. Ferguson, Ian Liu, Ming Cheng Mo, Jixiang Akinyi, Linnet Schmid, Kara Mondello, Stefania Robertson, Claudia S. Tortella, Frank C. Hayes, Ronald L. Wang, Kevin K. W. TI Elevated Levels of Serum Glial Fibrillary Acidic Protein Breakdown Products in Mild and Moderate Traumatic Brain Injury Are Associated With Intracranial Lesions and Neurosurgical Intervention SO ANNALS OF EMERGENCY MEDICINE LA English DT Article ID NEURON-SPECIFIC-ENOLASE; SEVERE HEAD-INJURY; COMPUTED-TOMOGRAPHY; OUTCOME PREDICTION; RADIATION-EXPOSURE; S-100B PROTEIN; CANCER-RISKS; ACUTE STROKE; S100B; CT AB Study objective: This study examines whether serum levels of glial fibrillary acidic protein breakdown products (GFAP-BDP) are elevated in patients with mild and moderate traumatic brain injury compared with controls and whether they are associated with traumatic intracranial lesions on computed tomography (CT) scan (positive CT result) and with having a neurosurgical intervention. Methods: This prospective cohort study enrolled adult patients presenting to 3 Level I trauma centers after blunt head trauma with loss of consciousness, amnesia, or disorientation and a Glasgow Coma Scale (GCS) score of 9 to 15. Control groups included normal uninjured controls and trauma controls presenting to the emergency department with orthopedic injuries or a motor vehicle crash without traumatic brain injury. Blood samples were obtained in all patients within 4 hours of injury and measured by enzyme.linked immunosorbent assay for GFAP-BDP (nanograms/milliliter). Results: Of the 307 patients enrolled, 108 were patients with traumatic brain injury (97 with GCS score 13 to 15 and 11 with GCS score 9 to 12) and 199 were controls (176 normal controls and 16 motor vehicle crash controls and 7 orthopedic controls). Receiver operating characteristic curves demonstrated that early GFAP-BDP levels were able to distinguish patients with traumatic brain injury from uninjured controls with an area under the curve of 0.90 (95% confidence interval [Cl] 0.86 to 0.94) and differentiated traumatic brain injury with a GCS score of 15 with an area under the curve of 0.88 (95% Cl 0.82 to 0.93). Thirty-two patients with traumatic brain injury (30%) had lesions on CT. The area under these curves for discriminating patients with CT lesions versus those without CT lesions was 0.79 (95% Cl 0.69 to 0.89). Moreover, the receiver operating characteristic curve for distinguishing neurosurgical intervention from no neurosurgical intervention yielded an area under the curve of 0.87 (95% Cl 0.77 to 0.96). Conclusion: GFAP-BDP is detectable in serum within an hour of injury and is associated with measures of injury severity, including the GCS score, CT lesions, and neurosurgical intervention. Further study is required to validate these findings before clinical application. [Ann Emerg Med. 2012;59:471-483.] C1 [Papa, Linda; Falk, Jay L.; Silvestri, Salvatore; Giordano, Philip] Orlando Reg Med Ctr Inc, Dept Emergency Med, Orlando, FL USA. [Lewis, Lawrence M.; Ferguson, Ian] Washington Univ, Sch Med, Div Emergency Med, St Louis, MO USA. [Zhang, Zhiqun; Liu, Ming Cheng; Mo, Jixiang; Akinyi, Linnet; Mondello, Stefania; Hayes, Ronald L.; Wang, Kevin K. W.] Banyan Biomarkers Inc, Alachua, FL USA. [Brophy, Gretchen M.] Virginia Commonwealth Univ, Richmond, VA USA. [Demery, Jason A.] Univ Florida, Forens Inst, UF Springhill Hlth Ctr, Gainesville, FL USA. [Dixit, Neha K.] NF SG Vet Hlth Syst, Psychol Serv, Gainesville, FL USA. [Schmid, Kara; Tortella, Frank C.] Walter Reed Army Inst Res, Dept Appl Neurobiol, Div Psychiat & Neurosci, Silver Spring, MD USA. [Robertson, Claudia S.] Baylor Coll Med, Dept Crit Care & Neurosurg, Houston, TX 77030 USA. RP Papa, L (reprint author), Orlando Reg Med Ctr Inc, Dept Emergency Med, Orlando, FL USA. EM lpstat@aol.com; kawangwang17@gmail.com RI Mondello, Stefania/A-1813-2012; Ferguson, Ian/C-1874-2016; OI Mondello, Stefania/0000-0002-8587-3614; Ferguson, Ian/0000-0003-3060-414X; Wang, Kevin/0000-0002-9343-6473 FU Department of Defense [DoD W81XWH-06-1-0517]; National Institute of Neurological Disorders and Stroke [R01NS057676] FX By Annals policy, all authors are required to disclose any and all commercial, financial, and other relationships in any way related to the subject of this article as per ICMJE conflict of interest guidelines (see www.icmje.org). This study was supported in part by Department of Defense Award number DoD W81XWH-06-1-0517. Material has been reviewed by the Walter Reed Army Institute of Research. There is no objection to its presentation or publication. The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting true views of Department of the Army or Department of Defense. The project described was supported in part by award number R01NS057676 from the National Institute of Neurological Disorders and Stroke. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institute of Neurological Disorders and Stroke or the National Institutes of Health. Drs. Papa, Brophy, and Demery are consultants of Banyan Biomarkers, Inc. but receive no stocks or royalties from the company and will not benefit financially from this publication. Drs. Liu, Mo, Zhang, and Mondello and Ms. Akinyi are employees of Banyan Biomarkers, Inc. Drs. Wang and Hayes own stock, receive royalties from, and are officers of Banyan Biomarkers Inc. and as such may benefit financially as a result of the outcomes of this research or work reported in this publication. NR 69 TC 97 Z9 101 U1 0 U2 11 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0196-0644 J9 ANN EMERG MED JI Ann. Emerg. Med. PD JUN PY 2012 VL 59 IS 6 BP 471 EP 483 DI 10.1016/j.annemergmed.2011.08.021 PG 13 WC Emergency Medicine SC Emergency Medicine GA 959HA UT WOS:000305302300007 PM 22071014 ER PT J AU Bebarta, VS Pitotti, RL Dixon, P Lairet, JR Bush, A Tanen, DA AF Bebarta, Vikhyat S. Pitotti, Rebecca L. Dixon, Patricia Lairet, Julio R. Bush, Anneke Tanen, David A. TI Hydroxocobalamin Versus Sodium Thiosulfate for the Treatment of Acute Cyanide Toxicity in a Swine (Sus scrofa) Model SO ANNALS OF EMERGENCY MEDICINE LA English DT Article ID INDUCED CARDIAC-ARREST; SMOKE-INHALATION; NITRIC-OXIDE; GUINEA-PIGS; ANTIDOTE; PHARMACOKINETICS; INTOXICATION; EFFICACY; INJURY AB Study objective: We compare the efficacy of hydroxocobalamin to sodium thiosulfate to reverse the depressive effects on mean arterial pressure in a swine model of acute cyanide toxicity and gain a better understanding of the mechanism of action of the hydroxocobalamin in reversal of the toxicity. Methods: Swine were intubated, anesthetized, and instrumented with central arterial and venous lines and a pulmonary artery catheter. Animals (n=36) were randomly assigned to one of 3 groups: hydroxocobalamin alone (150 mg/kg), sodium thiosulfate alone (413 mg/kg), or hydroxocobalamin (150 mg/kg)+sodium thiosulfate (413 mg/kg) and monitored for 60 minutes after the start of antidotal infusion. Cyanide was infused until severe hypotension developed, defined as blood pressure 50% of baseline mean arterial pressure. Repeated-measures ANOVA was used to determine statistically significant changes between groups over time. Results: Time to hypotension (25, 28, and 33 minutes), cyanide dose at hypotension (4.7, 5.0, and 5.6 mg/kg), and mean cyanide blood levels (3.2, 3.7, and 3.8 mu g/mL) and lactate levels (7, 8.2, 8.3 and mmol/L) were similar. All 12 animals in the sodium thiosulfate group died compared with 2 of 12 in the hydroxocobalamin/sodium thiosulfate group and 1 of 12 in hydroxocobalamin group. No statistically significant differences were detected between the hydroxocobalamin and hydroxocobalamin/sodium thiosulfate groups for carbon monoxide, mean arterial pressure, cyanide levels, or mortality at 60 minutes. Lactate level (2.6 versus 2.1 mmol/L), pH (7.44 versus 7.42), and bicarbonate level (25 versus 26 mEq/L) at 60 minutes were also similar between groups. Conclusion: Sodium thiosulfate failed to reverse cyanide-induced shock in our swine model of severe cyanide toxicity. Further, sodium thiosulfate was not found to be effective when added to hydroxocobalamin in the treatment of cyanide-induced shock. Hydroxocobalamin alone was again found to be effective for severe cyanide toxicity. [Ann Emerg Med. 2012;59:532-539.] C1 [Bebarta, Vikhyat S.; Pitotti, Rebecca L.; Lairet, Julio R.] Wilford Hall USAF Med Ctr, Brooke Army Med Ctr, Dept Emergency Med, San Antonio, TX 78236 USA. [Dixon, Patricia; Bush, Anneke] Wilford Hall USAF Med Ctr, Brooke Army Med Ctr, Div Clin Res, San Antonio, TX 78236 USA. [Tanen, David A.] USN, Med Ctr, Dept Emergency Med, San Diego, CA 92152 USA. RP Bebarta, VS (reprint author), Wilford Hall USAF Med Ctr, Brooke Army Med Ctr, Dept Emergency Med, San Antonio, TX 78236 USA. EM vikbebarta@yahoo.com RI bebarta, vikhyat/K-3476-2015 FU US Air Force Office of the Surgeon General FX By Annals policy, all authors are required to disclose any and all commercial, financial, and other relationships in any way related to the subject of this article as per ICMJE conflict of interest guidelines (see www.icmje.org). The US Air Force Office of the Surgeon General funded this study. NR 38 TC 18 Z9 19 U1 1 U2 2 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0196-0644 J9 ANN EMERG MED JI Ann. Emerg. Med. PD JUN PY 2012 VL 59 IS 6 BP 532 EP 539 DI 10.1016/j.annemergmed.2012.01.022 PG 8 WC Emergency Medicine SC Emergency Medicine GA 959HA UT WOS:000305302300018 PM 22387086 ER PT J AU Sabatini, JJ Raab, JM Hann, RK Damavarapu, R Klapotke, TM AF Sabatini, Jesse J. Raab, James M. Hann, Ronald K., Jr. Damavarapu, Reddy Klapoetke, Thomas M. TI High-Nitrogen-Based Pyrotechnics: Development of Perchlorate-Free Green-Light Illuminants for Military and Civilian Applications SO CHEMISTRY-AN ASIAN JOURNAL LA English DT Article DE energetic materials; fireworks; heterocycles; pyrotechnics; sustainable chemistry ID DECHLORANE PLUS; ENERGETIC MATERIALS; GREAT-LAKES; SALTS AB The development of perchlorate-free hand-held signal illuminants for the US Armys M195 green star parachute is described. Compared with the perchlorate-containing control, the optimized perchlorate-free illuminants were less sensitive toward various ignition stimuli while offering comparable burn times and visible-light outputs. The results were also important from the perspective of civilian fireworks because the development of perchlorate-free illuminants remains an important objective of the commercial fireworks industry. C1 [Sabatini, Jesse J.] USA, RDECOM, ARDEC, Pyrotech Technol & Prototyping Div, Picatinny Arsenal, NJ 07806 USA. [Raab, James M.; Hann, Ronald K., Jr.] W Point Mil Acad, Dept Chem & Life Sci, West Point, NY 10996 USA. [Damavarapu, Reddy] USA, RDECOM, ARDEC, Energet & Warheads Res & Dev Div, Picatinny Arsenal, NJ 07806 USA. [Klapoetke, Thomas M.] Univ Munich, Dept Chem, D-81377 Munich, Germany. RP Sabatini, JJ (reprint author), USA, RDECOM, ARDEC, Pyrotech Technol & Prototyping Div, Bldg 1515, Picatinny Arsenal, NJ 07806 USA. EM jesse.sabatini@us.army.mil RI Klapoetke, Thomas/B-6055-2014 OI Klapoetke, Thomas/0000-0003-3276-1157 FU Environmental Quality Technology and Ordnance Environmental Programs; US Army (Picatinny Arsenal, NJ); Ludwig Maximilians University (Munich, Germany); Chemistry and Life Sciences Department at the United States Military Academy (West Point, NY) FX We are indebted to the Environmental Quality Technology and Ordnance Environmental Programs, the US Army (Picatinny Arsenal, NJ) and Ludwig Maximilians University (Munich, Germany) for funding of this work. We express many thanks to the Chemistry and Life Sciences Department at the United States Military Academy (West Point, NY) for their efforts in sponsoring and coordinating the Academic Individual Advanced Development (AIAD) program to further fund this work. We express our gratitude to Dr. Karl D. Oyler for providing particle-size data for all solid ingredients and to Henry Grau for providing the thermal onset values. We thank Dr. Mark S. Johnson and Dr. William S. Eck of the US Army Public Health Command (Aberdeen Proving Ground, MD) for their insightful discussions on the bioaccumulation potential of dechlorane plus. The invitation by Dr. Peter Golitz to submit this paper is gratefully acknowledged. NR 41 TC 20 Z9 20 U1 1 U2 34 PU WILEY-V C H VERLAG GMBH PI WEINHEIM PA BOSCHSTRASSE 12, D-69469 WEINHEIM, GERMANY SN 1861-4728 J9 CHEM-ASIAN J JI Chem.-Asian J. PD JUN PY 2012 VL 7 IS 7 BP 1657 EP 1663 DI 10.1002/asia.201200036 PG 7 WC Chemistry, Multidisciplinary SC Chemistry GA 958LR UT WOS:000305239500028 PM 22488721 ER PT J AU Finkel, AG Yerry, J Scher, A Choi, YS AF Finkel, Alan G. Yerry, Juanita Scher, Ann Choi, Young S. TI Headaches in Soldiers With Mild Traumatic Brain Injury: Findings and Phenomenologic Descriptions SO HEADACHE LA English DT Article DE headache diagnosis; post-traumatic headache; traumatic brain injury; blast; continuous headache; migraine ID TEMPOROMANDIBULAR DISORDER; CUTANEOUS ALLODYNIA; CHRONIC PAIN; MIGRAINE; EPIDEMIOLOGY; FIBROMYALGIA; COMORBIDITY; POPULATION; MECHANISMS; ASSOCIATION AB Objective.-The primary goal of this study was to use headache criteria-based classification for headache types described by service members. Background.-Headache is common in soldiers returning from the wars in Afghanistan and Iraq. To date, few papers have provided detailed descriptions of these headaches. Methods.-The first 25 patients seen by a certified headache specialist at the Traumatic Brain Injury Center at Womack Army Medical Center, Fort Bragg, NC, between August 2008 and December 2009 are reported. Results.-Service members described a total of 55 headaches. Most, but not all, headaches began within 1 week after injury. Migraine type was most common. Aura occurred in 5 soldiers. Continuous headaches were described in 88%. Uncommon headache types including cluster type were diagnosed. Additional symptoms and service outcomes are described. Conclusions.-We conclude that headaches occurring after various types of head injury, including explosions, can be assigned primary and secondary headache diagnoses using standard classifications not necessarily available to larger survey-based studies. C1 [Finkel, Alan G.] Carolina Headache Inst, Chapel Hill, NC 27516 USA. [Finkel, Alan G.; Yerry, Juanita; Choi, Young S.] Womack Army Med Ctr, Ft Bragg, NC USA. [Scher, Ann] Uniformed Serv Univ Hlth Sci, Bethesda, MD USA. [Finkel, Alan G.] Def & Vet Brain Injury Ctr, Rockville, MD USA. RP Finkel, AG (reprint author), Carolina Headache Inst, 103 Market St, Chapel Hill, NC 27516 USA. EM finkela@carolinaheadacheinstitute.com NR 40 TC 13 Z9 13 U1 0 U2 2 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0017-8748 J9 HEADACHE JI Headache PD JUN PY 2012 VL 52 IS 6 BP 957 EP 965 DI 10.1111/j.1526-4610.2012.02167.x PG 9 WC Clinical Neurology SC Neurosciences & Neurology GA 952OA UT WOS:000304800600004 PM 22568576 ER PT J AU Cheng, SF Tom, K Pecht, M AF Cheng, Shunfeng Tom, Kwok Pecht, Michael TI Anomaly Detection of Polymer Resettable Circuit Protection Devices SO IEEE TRANSACTIONS ON DEVICE AND MATERIALS RELIABILITY LA English DT Article DE Anomaly detection; cross-validation-based sequential probability ratio test; failure precursor parameter; polymer positive-temperature-coefficient (PPTC) resettable circuit protection device; power supply protection ID HEALTH MANAGEMENT; CROSS-VALIDATION; PROGNOSTICS; SYSTEMS; ALGORITHMS; FAILURE AB As circuit protection devices, failure or abnormal behavior of polymer positive-temperature-coefficient resettable devices can cause damage to circuits. It is necessary to detect anomalies in the resettable circuit protection devices to provide early warning of failure and avoid damage to a circuit. In this paper, a novel anomaly detection method, the cross-validation-based sequential probability ratio test, is developed and applied to the failure precursor parameters of the resettable circuit protection devices to conduct anomaly detection. The cross-validation-based sequential probability ratio test integrates the advantages of both the sequential probability ratio test for in situ anomaly detection and the cross-validation technique for model parameter selection to reduce the probability of false and missed alarms in anomaly detection. The cross-validation-based sequential probability ratio test solves the model parameter selection difficulty of the traditional sequential probability ratio test and improves its performance in anomaly detection. C1 [Cheng, Shunfeng] Univ Maryland, Prognost & Hlth Management Consortium, Ctr Adv Life Cycle Engn, College Pk, MD 20742 USA. [Tom, Kwok] USA, Res Lab, Adelphi, MD 20783 USA. [Pecht, Michael] City Univ Hong Kong, Ctr Prognost & Syst Hlth Management, Kowloon, Hong Kong, Peoples R China. RP Cheng, SF (reprint author), Intel Corp, Hillsboro, OR 97124 USA. EM shunfengcheng@gmail.com; kwok.tom.civ@mail.mil; pecht@calce.umd.edu OI Pecht, Michael/0000-0003-1126-8662 NR 30 TC 3 Z9 3 U1 3 U2 9 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1530-4388 J9 IEEE T DEVICE MAT RE JI IEEE Trans. Device Mater. Reliab. PD JUN PY 2012 VL 12 IS 2 BP 420 EP 427 DI 10.1109/TDMR.2011.2170689 PG 8 WC Engineering, Electrical & Electronic; Physics, Applied SC Engineering; Physics GA 956JE UT WOS:000305085100031 ER PT J AU Stockstill, RL Maynord, ST Hite, JE AF Stockstill, Richard L. Maynord, Stephen T. Hite, John E., Jr. TI Discussion of "Stop Logs for Emergency Spillway Gate Dewatering" by Derek R. Freckleton, Michael C. Johnson, M. Leslie Boyd, and Dustin G. Mortensen SO JOURNAL OF HYDRAULIC ENGINEERING-ASCE LA English DT Editorial Material C1 [Stockstill, Richard L.; Maynord, Stephen T.; Hite, John E., Jr.] USA, Engr Res & Devel Ctr, Coast & Hydr Lab, Vicksburg, MS 39180 USA. RP Stockstill, RL (reprint author), USA, Engr Res & Devel Ctr, Coast & Hydr Lab, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM Richard.L.Stockstill@usace.army.mil NR 8 TC 0 Z9 0 U1 0 U2 1 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 0733-9429 J9 J HYDRAUL ENG-ASCE JI J. Hydraul. Eng.-ASCE PD JUN PY 2012 VL 138 IS 6 BP 574 EP 576 DI 10.1061/(ASCE)HY.1943-7900.0000535 PG 3 WC Engineering, Civil; Engineering, Mechanical; Water Resources SC Engineering; Water Resources GA 956LP UT WOS:000305091400011 ER PT J AU Baird, CP DeBakey, S Reid, L Hauschild, VD Petruccelli, B Abraham, JH AF Baird, Coleen P. DeBakey, Samar Reid, Lawrence Hauschild, Veronique D. Petruccelli, Bruno Abraham, Joseph H. TI Respiratory Health Status of US Army Personnel Potentially Exposed to Smoke From 2003 Al-Mishraq Sulfur Plant Fire SO JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE LA English DT Article ID HYDROGEN-SULFIDE; AFGHANISTAN; INHALATION; SYMPTOMS; IRAQ AB Objective: To assess the impact of exposure to a 2003 sulfur plant fire on the health of deployed US Army personnel. Methods: The authors identified a small firefighter group known to be at the fire source and a larger, more dispersed population. Self-reported health status and respiratory health outcomes for these two groups were reviewed compared with two unexposed groups. Results: Self-reported health concerns, difficulty breathing, and shortness of breath were common in the exposed. Rates for chronic respiratory conditions increased in all groups from before to after deployment. Postdeploymont medical encounters for chronic respiratory conditions among the exposed did not differ significantly from the unexposed comparison groups. Conclusion: Potential exposure to the sulfur fire was positively associated with self-reported health concerns and symptoms but not with clinical encounters for chronic respiratory health conditions. C1 [Baird, Coleen P.] USA, Publ Hlth Command, Environm Med Program, Aberdeen Proving Ground, MD 21010 USA. [DeBakey, Samar; Reid, Lawrence] Hlth Res & Anal, Rockville, MD USA. RP Baird, CP (reprint author), USA, Publ Hlth Command, Environm Med Program, 5158 Black Hawk Rd, Aberdeen Proving Ground, MD 21010 USA. EM coleen.baird@us.army.mil FU US Department of Defense FX This work was supported by the US Department of Defense. NR 20 TC 15 Z9 15 U1 0 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1076-2752 J9 J OCCUP ENVIRON MED JI J. Occup. Environ. Med. PD JUN PY 2012 VL 54 IS 6 SI SI BP 717 EP 723 DI 10.1097/JOM.0b013e3182572e37 PG 7 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 957MA UT WOS:000305165900010 PM 22610092 ER PT J AU Abraham, JH Baird, CP AF Abraham, Joseph H. Baird, Coleen P. TI A Case-Crossover Study of Ambient Particulate Matter and Cardiovascular and Respiratory Medical Encounters Among US Military Personnel Deployed to Southwest Asia SO JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE LA English DT Article ID AIR-POLLUTION; CIGARETTE-SMOKING; HEALTH; AFGHANISTAN; SYMPTOMS; EXPOSURE; SOLDIERS; RISK; STRATEGIES; AEROSOLS AB Objective: To evaluate the impact of ambient particulate matter (PM) on acute cardiorespiratory morbidity among US military personnel in southwest Asia. Methods: We linked ambient PM data collected between December 2005 and June 2007 with personnel, medical, and meteorological data. We implemented a case-crossover analysis to estimate base-specific associations and pooled those estimates using meta-analytic methods. Results: The adjusted odds ratios for a 10-mu g/m(3) increase in ambient PM2.5 and a qualifying medical encounter were 0.92 (95% confidence interval [CI]: 0.77 to 1.11) and 1.01 (95% CI: 0.95 to 1.07) for the current (lag_0) and previous (lag_1) days. The estimates for a 10-mu g/m(3) increase in PM10 were 0.99 (95% CI: 0.97 to 1.03) at lag_0, and 1.00 (95% CI: 0.97 to 1.02) at lag_l. Conclusions: No statistically significant associations between PM and cardiorespiratory outcomes were observed in this young, relatively healthy, deployed military population. C1 [Abraham, Joseph H.; Baird, Coleen P.] USA, Publ Hlth Command, Aberdeen Proving Ground, MD 21010 USA. RP Abraham, JH (reprint author), USA, Publ Hlth Command Provis, Environm Med Program, 5158 Black Hawk Rd, Aberdeen Proving Ground, MD 21010 USA. EM joseph.h.abraham@us.army.mil FU US Department of Defense FX This work was supported by the US Department of Defense. NR 31 TC 14 Z9 14 U1 0 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1076-2752 J9 J OCCUP ENVIRON MED JI J. Occup. Environ. Med. PD JUN PY 2012 VL 54 IS 6 SI SI BP 733 EP 739 DI 10.1097/JOM.0b013e318253356c PG 7 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 957MA UT WOS:000305165900012 PM 22547122 ER PT J AU Abraham, JH DeBakey, SF Reid, L Zhou, J Baird, CP AF Abraham, Joseph H. DeBakey, Samar F. Reid, Lawrence Zhou, Joey Baird, Coleen P. TI Does Deployment to Iraq and Afghanistan Affect Respiratory Health of US Military Personnel? SO JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE LA English DT Article ID OBSTRUCTIVE PULMONARY-DISEASE; SYMPTOMS; IMPACT AB Objective: To evaluate the association between postdeployment respiratory conditions and deployment to Iraq or Afghanistan. Methods: We linked deployment history of US military personnel with postdeployment medical records. We then conducted a nested case-control study. Results: Relative to a single deployment, multiple deployments were not significantly associated with obstructive pulmonary disease (odds ratio, 1.08; 95% confidence interval, 0.82 to 1.42). Cumulative time deployed was also not significantly associated with obstructive pulmonary disease. Nevertheless, we did note that the rate of respiratory symptoms and encounters for obstructive pulmonary diseases (predominantly asthma and bronchitis) increased from before to after deployment. Conclusions: In a population of active duty US military personnel, we observed an increase in postdeployment respiratory symptoms and medical encounters for obstructive pulmonary diseases, relative to predeployment rates, in the absence of an association with cumulative deployment duration or total number of deployments. C1 [Abraham, Joseph H.; Zhou, Joey; Baird, Coleen P.] USA, Publ Hlth Command, Aberdeen Proving Ground, MD 21010 USA. [DeBakey, Samar F.; Reid, Lawrence] Hlth Res & Anal, Rockville, MD USA. RP Baird, CP (reprint author), USA, Publ Hlth Command, 5158 Blackhawk Rd, Aberdeen Proving Ground, MD 21010 USA. EM coleen.weese@us.army.mil FU US Department of Defense FX This work was supported by the US Department of Defense. NR 16 TC 21 Z9 21 U1 1 U2 5 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1076-2752 J9 J OCCUP ENVIRON MED JI J. Occup. Environ. Med. PD JUN PY 2012 VL 54 IS 6 SI SI BP 740 EP 745 DI 10.1097/JOM.0b013e318252969a PG 6 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 957MA UT WOS:000305165900013 PM 22588475 ER PT J AU Rose, C Abraham, J Harkins, D Miller, R Morris, M Zacher, L Meehan, R Szema, A Tolle, J King, M Jackson, D Lewis, J Stahl, A Lyles, MB Hodgson, M Teichman, R Salihi, W Matwiyoff, G Meeker, G Mormon, S Bird, K Baird, C AF Rose, Cecile Abraham, Joseph Harkins, Deanna Miller, Robert Morris, Michael Zacher, Lisa Meehan, Richard Szema, Anthony Tolle, James King, Matthew Jackson, David Lewis, John Stahl, Andrea Lyles, Mark B. Hodgson, Michael Teichman, Ronald Salihi, Walid Matwiyoff, Gregory Meeker, Gregory Mormon, Suzette Bird, Kathryn Baird, Coleen TI Overview and Recommendations for Medical Screening and Diagnostic Evaluation for Postdeployment Lung Disease in Returning US Warfighters SO JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE LA English DT Article ID RESPIRATORY SYMPTOMS; AFGHANISTAN; IRAQ; BRONCHIOLITIS; EXPOSURE; ASTHMA; IMPACT AB Objective: To review inhalational exposures and respiratory disease risks in US military personnel deployed to Iraq and Afghanistan and to develop consensus recommendations for medical screening and diagnostic referral. Methods: A Working Group of physicians and exposure scientists from academia and from the Departments of Defense and Veterans Affairs was convened in February 2010. Results: Despite uncertainty about the number of people affected and risk factors for adverse pulmonary outcomes in this occupational setting, the Working Group recommended: (1) standardized approaches to pre-and postdeployment medical surveillance; (2) criteria for medical referral and diagnosis; and (3) case definitions for major deployment-related lung diseases. Conclusions: There is a need for targeted, practical medical surveillance for lung diseases and for a standardized diagnostic approach for all symptomatic deployed personnel. C1 [Rose, Cecile; Meehan, Richard; Bird, Kathryn] Natl Jewish Hlth, Dept Med, Denver, CO 80206 USA. Univ Colorado Denver, Denver, CO USA. [Abraham, Joseph; Harkins, Deanna; Baird, Coleen] USA, Publ Hlth Command, Aberdeen Proving Ground, MD USA. [Miller, Robert; Tolle, James; King, Matthew] Vanderbilt Univ, Sch Med, Nashville, TN 37212 USA. [Morris, Michael; Zacher, Lisa] Brooke Army Med Ctr, Dept Med, Ft Sam Houston, TX 78234 USA. [Szema, Anthony; Salihi, Walid] SUNY Stony Brook, Sch Med, Stony Brook, NY 11794 USA. Vet Affairs Med Ctr, Northport, NY USA. [Jackson, David; Lewis, John; Stahl, Andrea] USA, Ctr Environm Hlth Res, Ft Detrick, MD USA. [Lyles, Mark B.] USN, War Coll, Washington, DC USA. [Hodgson, Michael] Dept Vet Affairs, VHA, Off Publ Hlth, Washington, DC USA. [Teichman, Ronald] Dept Vet Affairs, VA New Jersey Hlth Care Syst, War Related Illness & Injury Study Ctr, E Orange, NJ USA. [Matwiyoff, Gregory] Navy Med Ctr, San Diego, CA USA. [Meeker, Gregory; Mormon, Suzette] US Geol Survey, Denver, CO 80225 USA. RP Rose, C (reprint author), Natl Jewish Hlth, Dept Med, 1400 Jackson St, Denver, CO 80206 USA. EM rosec@njhealth.org RI Meehan, Richard/B-5556-2012 FU Department of Defense FX Author Rose received a Department of Defense grant in 2011; she receives royalties from a contribution to a chapter in an online journal on silicosis. She and her coauthors have no relationships/conditions/circumstances that present potential conflict of interest. NR 21 TC 14 Z9 14 U1 0 U2 9 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1076-2752 J9 J OCCUP ENVIRON MED JI J. Occup. Environ. Med. PD JUN PY 2012 VL 54 IS 6 SI SI BP 746 EP 751 DI 10.1097/JOM.0b013e31825297ba PG 6 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 957MA UT WOS:000305165900014 PM 22588477 ER PT J AU Zacher, LL Browning, R Bisnett, T Bennion, JR Postlewaite, RC Baird, CP AF Zacher, Lisa L. Browning, Robert Bisnett, Teresa Bennion, James R. Postlewaite, R. Craig Baird, Coleen P. TI Clarifications From Representatives of the Department of Defense Regarding the Article "Recommendations for Medical Screening and Diagnostic Evaluation for Postdeployment Lung Disease in Returning US Warfighters" SO JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE LA English DT Editorial Material C1 [Zacher, Lisa L.] USA, Brooke Army Med Ctr, Off Surg Gen, Ft Sam Houston, TX USA. [Browning, Robert] USN, Walter Reed Natl Mil Med Ctr, Washington, DC USA. [Bisnett, Teresa] USAF, Washington, DC 20330 USA. [Bennion, James R.] USAF, Med Support Agcy, Washington, DC 20330 USA. [Postlewaite, R. Craig] Off Assistant Secretary Def Hlth Affairs, Falls Church, VA USA. [Baird, Coleen P.] USA, Publ Hlth Command, Aberdeen, MD USA. RP Baird, CP (reprint author), USA, Publ Hlth Command, 5158 Blackhawk Rd, Aberdeen Proving Ground, MD 21010 USA. EM coleen.weese@us.army.mil NR 7 TC 7 Z9 7 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1076-2752 J9 J OCCUP ENVIRON MED JI J. Occup. Environ. Med. PD JUN PY 2012 VL 54 IS 6 SI SI BP 760 EP 761 DI 10.1097/JOM.0b013e31824fe102 PG 2 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 957MA UT WOS:000305165900016 PM 22684322 ER PT J AU Huang, EKW Pour, SA Hoang, MA Haddadi, A Razeghi, M Tidrow, MZ AF Huang, Edward Kwei-wei Pour, Siamak Abdollahi Hoang, Minh-Anh Haddadi, Abbas Razeghi, Manijeh Tidrow, Meimei Z. TI Low irradiance background limited type-II superlattice MWIR M-barrier imager SO OPTICS LETTERS LA English DT Article AB We report a type-II superlattice mid-wave infrared 320 x 256 imager at 81 K with the M-barrier design that achieved background limited performance (BLIP) and similar to 99% operability. The 280 K blackbody's photon irradiance was limited by an aperture and a band-pass filter from 3.6 mu m to 3.8 mu m resulting in a total flux of similar to 5 x 10(12) ph.cm(-2).s(-1). Under these low-light conditions, and consequently the use of a 13.5 ms integration time, the imager was observed to be BLIP thanks to a similar to 5 pA dark current from the 27 mu m wide pixels. The total noise was dominated by the photon flux and read-out circuit which gave the imager a noise equivalent input of similar to 5 x 10(10) ph.cm(-2).s(-1) and temperature sensitivity of 9 mK with F/2.3 optics. Excellent imagery obtained using a 1-point correction alludes to the array's uniform responsivity. (C) 2012 Optical Society of America C1 [Huang, Edward Kwei-wei; Pour, Siamak Abdollahi; Hoang, Minh-Anh; Haddadi, Abbas; Razeghi, Manijeh] Northwestern Univ, Dept Elect Engn & Comp Sci, Evanston, IL 60208 USA. [Tidrow, Meimei Z.] USA, Night Vis & Elect Sensors Directorate, Ft Belvoir, VA 22060 USA. RP Razeghi, M (reprint author), Northwestern Univ, Dept Elect Engn & Comp Sci, Evanston, IL 60208 USA. EM razeghi@eecs.northwestern.edu RI Razeghi, Manijeh/B-7265-2009 NR 10 TC 6 Z9 6 U1 0 U2 4 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 0146-9592 J9 OPT LETT JI Opt. Lett. PD JUN 1 PY 2012 VL 37 IS 11 BP 2025 EP 2027 PG 3 WC Optics SC Optics GA 956JD UT WOS:000305085000083 PM 22660109 ER PT J AU Thiruvengadathan, R Belarde, GM Bezmelnitsyn, A Shub, M Balas-Hummers, W Gangopadhyay, K Gangopadhyay, S AF Thiruvengadathan, Rajagopalan Belarde, Gianetta Maria Bezmelnitsyn, Andrey Shub, Maxim Balas-Hummers, Wendy Gangopadhyay, Keshab Gangopadhyay, Shubhra TI Combustion Characteristics of Silicon-Based Nanoenergetic Formulations with Reduced Electrostatic Discharge Sensitivity SO PROPELLANTS EXPLOSIVES PYROTECHNICS LA English DT Article DE Nanoenergetics; Silicon; Combustion; Nanowires; ESD sensitivity ID POROUS SILICON; EXPLOSIVE DEVICES; SI NANOWIRES; COMPOSITES; NANOTUBES; NANO; NANOTHERMITES; NANOPARTICLES; MORPHOLOGY; THERMITES AB This paper details the synthesis and combustion characteristics of silicon-based nanoenergetic formulations. Silicon nanostructured powder (with a wide variety of morphologies such as nanoparticles, nanowires, and nanotubes) were produced by DC plasma arc discharge route. These nanostructures were passivated with oxygen and hydrogen post-synthesis. Their structural, morphological, and vibrational properties were investigated using X-ray diffractometry, transmission electron microscopy (TEM), nitrogen adsorption-desorption analysis, Fourier transform infrared (FTIR) spectrometry and Raman spectroscopy. The silicon nanostructured powder (fuel) was mixed with varying amounts of sodium perchlorate (NaClO4) nanoparticles (oxidizer) to form nanoenergetic mixtures. The NaClO4 nanoparticles with a size distribution in the range of 540 nm were prepared using surfactant in a mixed solvent system. The combustion characteristics, namely (i) the combustion wave speed and (ii) the pressure-time characteristics, were measured. The observed correlation between the basic material properties and the measured combustion characteristics is presented. These silicon-based nanoenergetic formulations exhibit reduced sensitivity to electrostatic discharge (ESD). C1 [Thiruvengadathan, Rajagopalan; Belarde, Gianetta Maria; Bezmelnitsyn, Andrey; Shub, Maxim; Gangopadhyay, Keshab; Gangopadhyay, Shubhra] Univ Missouri, Dept Elect & Comp Engn, Columbia, MO 65211 USA. [Balas-Hummers, Wendy] USA, ARDEC, Picatinny Arsenal, NJ 07806 USA. [Gangopadhyay, Keshab] Univ Missouri, Nucl Sci & Engn Inst, Columbia, MO 65211 USA. [Gangopadhyay, Keshab] NEMS MEMS WORKS LLC, Columbia, MO 65211 USA. RP Thiruvengadathan, R (reprint author), Univ Missouri, Dept Elect & Comp Engn, Columbia, MO 65211 USA. EM gangopadhyays@missouri.edu OI Thiruvengadathan, Rajagopalan/0000-0001-9609-3245 FU US Army ARDEC, Picatinny, New Jersey [DAAE30-01-9-0800 Tosa 82] FX The authors gratefully acknowledge the funding support provided by US Army ARDEC, Picatinny, New Jersey. (Contract # DAAE30-01-9-0800 Tosa 82). NR 51 TC 13 Z9 13 U1 2 U2 16 PU WILEY-V C H VERLAG GMBH PI WEINHEIM PA POSTFACH 101161, 69451 WEINHEIM, GERMANY SN 0721-3115 EI 1521-4087 J9 PROPELL EXPLOS PYROT JI Propellants Explos. Pyrotech. PD JUN PY 2012 VL 37 IS 3 BP 359 EP 372 DI 10.1002/prep.201100129 PG 14 WC Chemistry, Applied; Engineering, Chemical SC Chemistry; Engineering GA 958NV UT WOS:000305247000015 ER PT J AU Knapik, JJ Spiess, A Grier, T Sharp, MA Lester, ME Marin, R Jones, BH AF Knapik, J. J. Spiess, A. Grier, T. Sharp, M. A. Lester, M. E. Marin, R. Jones, B. H. TI Injuries before and after deployments to Afghanistan and Iraq SO PUBLIC HEALTH LA English DT Article DE Military personnel; Age; Ethnicity; Educational level; Post-traumatic stress ID GULF-WAR VETERANS; POSTWAR HOSPITALIZATION EXPERIENCE; POSTTRAUMATIC-STRESS-DISORDER; PHYSICAL-TRAINING PROGRAM; RISK-FACTORS; BOSNIA-HERZEGOVINA; VIETNAM VETERANS; MILITARY SERVICE; FOLLOW-UP; POSTSERVICE MORTALITY AB Objective: To examine outpatient injuries before and after deployments of elements of the 10th Mountain Division to Afghanistan (n = 505 men) and the 1st Cavalry Division to Iraq (n = 3242 men). Study design: Observational. Methods: The military units provided a list of deployed soldiers, and soldiers' outpatient medical encounters were obtained from the Defense Medical Surveillance System. Cumulative injury incidence was examined for two consecutive 90-day periods before the deployments (Periods 1-2) and two consecutive 90-day periods after the deployments (Periods 3-4). Results: Both groups showed post-deployment increases in the overall incidence of injury (Afghanistan group = 14.1%, 14.1%, 16.4, 23.4%; Iraq Group = 15.1%, 12.4%, 35.4%, 43.4%; Periods 1-4, respectively). Soldiers with pre-deployment injuries were 1.4-3.0 times more likely to experience post-deployment injuries. Conclusions: This study found a post-deployment increase in the incidence of outpatient injury. Also, soldiers with pre-deployment injuries were more likely to experience post-deployment injuries. Published by Elsevier Ltd on behalf of The Royal Society for Public Health. C1 [Knapik, J. J.; Spiess, A.; Grier, T.; Jones, B. H.] USA, Inst Publ Hlth, Aberdeen Proving Ground, MD 21010 USA. [Sharp, M. A.] USA, Environm Med Res Inst, Natick, MA 01760 USA. [Lester, M. E.] USA, Inst Surg Res, Army Burn Ctr, Ft Sam Houston, TX 78234 USA. [Marin, R.] Womack Army Med Ctr, Dept Occupat Med, Ft Bragg, NC USA. RP Knapik, JJ (reprint author), USA, Inst Publ Hlth, Aberdeen Proving Ground, MD 21010 USA. EM joseph.knapik@us.army.mil FU Military Training Task Force of the Defense Safety Oversight Council, Department of Defense FX This study was funded by the Military Training Task Force of the Defense Safety Oversight Council, Department of Defense. The views, opinions and/or findings contained in this report are those of the authors and should not be construed as official Department of the Army position, policy or decision, unless so designated by other official documentation. Approved for public release; distribution is unlimited. NR 74 TC 5 Z9 5 U1 3 U2 3 PU W B SAUNDERS CO LTD PI LONDON PA 32 JAMESTOWN RD, LONDON NW1 7BY, ENGLAND SN 0033-3506 EI 1476-5616 J9 PUBLIC HEALTH JI Public Health PD JUN PY 2012 VL 126 IS 6 BP 498 EP 506 DI 10.1016/j.puhe.2012.01.031 PG 9 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 958YL UT WOS:000305276800006 PM 22361434 ER PT J AU Manak, M Sina, S Anekella, B Hewlett, I Sanders-Buell, E Ragupathy, V Kim, J Vermeulen, M Stramer, SL Sabino, E Grabarczyk, P Michael, N Peel, S Garrett, P Tovanabutra, S Busch, MP Schito, M AF Manak, Mark Sina, Silvana Anekella, Bharathi Hewlett, Indira Sanders-Buell, Eric Ragupathy, Viswanath Kim, Jerome Vermeulen, Marion Stramer, Susan L. Sabino, Ester Grabarczyk, Piotr Michael, Nelson Peel, Sheila Garrett, Patricia Tovanabutra, Sodsai Busch, Michael P. Schito, Marco TI Pilot Studies for Development of an HIV Subtype Panel for Surveillance of Global Diversity SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Article ID HUMAN-IMMUNODEFICIENCY-VIRUS; POLYMERASE CHAIN-REACTION; VIRAL-LOAD ASSAYS; DISEASE PROGRESSION; GENETIC-CHARACTERIZATION; TYPE-1 INFECTION; TRANSMISSION; RESISTANCE; PROTEASE; DYNAMICS AB The continued global spread and evolution of HIV diversity pose significant challenges to diagnostics and vaccine strategies. NIAID partnered with the FDA, WRAIR, academia, and industry to form a Viral Panel Working Group to design and prepare a panel of well-characterized current and diverse HIV isolates. Plasma samples that had screened positive for HIV infection and had evidence of recently acquired infection were donated by blood centers in North and South America, Europe, and Africa. A total of 80 plasma samples were tested by quantitative nucleic acid tests, p24 antigen, EIA, and Western blot to assign a Fiebig stage indicative of approximate time from initial infection. Evaluation of viral load using FDA-cleared assays showed excellent concordance when subtype B virus was tested, but lower correlations for subtype C. Plasma samples were cocultivated with phytohemagglutinin (PHA)-stimulated peripheral blood mononuclear cells (PBMCs) from normal donors to generate 30 viral isolates (50-80% success rate for samples with viral load >10,000 copies/ml), which were then expanded to 10(7)-10(9) virus copies per ml. Analysis of env sequences showed that sequences derived from cultured PBMCs were not distinguishable from those obtained from the original plasma. The pilot collection includes 30 isolates representing subtypes B, C, B/F, CRF04_cpx, and CRF02_AG. These studies will serve as a basis for the development of a comprehensive panel of highly characterized viral isolates that reflects the current dynamic and complex HIV epidemic, and will be made available through the External Quality Assurance Program Oversight Laboratory (EQAPOL). C1 [Manak, Mark] Henry M Jackson Fdn Adv Mil Med, Dept Diagnost & Monitoring, US Mil HIV Res Program, Rockville, MD 20850 USA. [Manak, Mark; Anekella, Bharathi; Garrett, Patricia] SeraCare Life Sci Inc, Gaithersburg, MD USA. [Hewlett, Indira; Ragupathy, Viswanath] US FDA, CBER, Bethesda, MD 20014 USA. [Kim, Jerome; Michael, Nelson; Peel, Sheila] Walter Reed Army Inst Res, US Mil HIV Res Program, Rockville, MD USA. [Vermeulen, Marion] S African Natl Blood Serv, Gauteng, South Africa. [Stramer, Susan L.] Amer Red Cross, Sci Support Off, Gaithersburg, MD USA. [Sabino, Ester] Univ Sao Paulo, Dept Infect Dis, Sao Paulo, Brazil. [Grabarczyk, Piotr] Inst Haematol & Blood Transfus Med, Warsaw, Poland. [Busch, Michael P.] Blood Syst Res Inst, San Francisco, CA USA. [Schito, Marco] Henry M Jackson Fdn, Bethesda, MD USA. [Schito, Marco] NIH, Div Aids, Bethesda, MD 20892 USA. RP Manak, M (reprint author), Henry M Jackson Fdn Adv Mil Med, Dept Diagnost & Monitoring, US Mil HIV Res Program, 13 Taft Court, Rockville, MD 20850 USA. EM mmanak@hivresearch.org RI Imunologia, Inct/I-2124-2013; sourisseau, marion/M-7542-2014; Sabino, Ester/F-7750-2010; OI Sabino, Ester/0000-0003-2623-5126; Manak, Mark /0000-0002-9217-9129 FU National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Health and Human Services [HHSN272200800014C]; Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. [W81XWH-07-2-0067]; U.S. Department of Defense (DoD) [W81XWH-07-2-0067] FX This project has been funded in part with Federal funds from the National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Health and Human Services, under Contract No. HHSN272200800014C. This work was also supported by a cooperative agreement W81XWH-07-2-0067 between the Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. and the U.S. Department of Defense (DoD). NR 40 TC 12 Z9 13 U1 1 U2 6 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0889-2229 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD JUN PY 2012 VL 28 IS 6 BP 594 EP 606 DI 10.1089/aid.2011.0271 PG 13 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA 952GQ UT WOS:000304780100011 PM 22149143 ER PT J AU Pallis, M Svoboda, SJ Cameron, KL Owens, BD AF Pallis, Mark Svoboda, Steven J. Cameron, Kenneth L. Owens, Brett D. TI Survival Comparison of Allograft and Autograft Anterior Cruciate Ligament Reconstruction at the United States Military Academy SO AMERICAN JOURNAL OF SPORTS MEDICINE LA English DT Article; Proceedings Paper CT 37th Annual Meeting of the American-Orthopaedic-Society-for-Sports-Medicine (AOSSM) CY JUL, 2011 CL San Diego, CA SP Amer Orthopaed Soc Sports Med (AOSSM) DE anterior cruciate ligament; reconstruction; allograft; autograft; revision ID PATELLAR TENDON AUTOGRAFT; ANKLE SPRAIN; EPIDEMIOLOGY; INJURY; 5-YEAR; LEVEL; YOUNG AB Background: There is recent evidence that use of allograft tendons for anterior cruciate ligament (ACL) reconstruction in young patients may result in increased failure rates compared with autologous grafts. Hypothesis: Allograft ACL reconstruction will result in higher failure rates in young athletes compared with autograft reconstruction. Study Design: Cohort study; Level of evidence, 2. Methods: A prospective cohort study of cadets at the United States Military Academy (USMA) was performed to assess performance of ACL reconstructions performed before entrance to service. Members of the classes of 2007 through 2013 who had undergone prior ACL reconstruction were identified through the Department of Defense Medical Evaluation Review Board reporting and waiver process and evaluated on the first day of matriculation. These participants were followed during their tenure at the academy with revision ACL reconstruction as the primary outcome measure of interest. Kaplan-Meier survival analysis was performed for all graft types using STATA with significance set as P < .05. Results: A total of 120 cadets underwent 122 ACL reconstructions (2 bilateral) before matriculation and compose the prospective cohort. This cohort included 30 female and 90 male cadets. Of these 122 knees with prior ACL reconstructions, the grafts used were 61 bone-patellar tendon-bone (BTB), 45 hamstring, and 16 allograft. A total of 20 failures occurred among this cohort at an average of 545 days from matriculation. Of the failures requiring revision, 7 were BTB (11% of all BTB), 7 were allograft (44% of all allograft), and 6 were hamstring (13% of all hamstring). There was no significant difference in the graft failure between the BTB and hamstring autograft groups. In contrast, those who entered the USMA with an allograft were 7.7 times more likely to experience a subsequent graft failure during the follow-up period when compared with the BTB autograft group (hazard ratio = 7.74; 95% confidence interval [CI], 2.67-22.38; P < .001). When allografts were compared with all autografts combined, a similar increase failure was noted in the allograft group (hazard ratio = 6.71; 95% CI, 2.64-17.06; P < .001). Conclusion: In this young active cohort, individuals having undergone an allograft ACL reconstruction were significantly more likely to experience clinical failure requiring revision reconstruction compared with those who underwent autologous graft reconstruction. The authors recommend the use of autograft in ACL reconstruction in young athletes. C1 [Pallis, Mark; Svoboda, Steven J.; Cameron, Kenneth L.; Owens, Brett D.] US Mil Acad, Keller Army Hosp, Orthoped Surg Serv, West Point, NY 10996 USA. RP Owens, BD (reprint author), US Mil Acad, Keller Army Hosp, Orthoped Surg Serv, West Point, NY 10996 USA. EM b.owens@us.army.mil OI Cameron, Kenneth/0000-0002-6276-4482 NR 13 TC 42 Z9 43 U1 0 U2 12 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0363-5465 J9 AM J SPORT MED JI Am. J. Sports Med. PD JUN PY 2012 VL 40 IS 6 BP 1242 EP 1246 DI 10.1177/0363546512443945 PG 5 WC Orthopedics; Sport Sciences SC Orthopedics; Sport Sciences GA 951CA UT WOS:000304697100003 PM 22534281 ER PT J AU Deye, GA Gettayacamin, M Hansukjariya, P Im-erbsin, R Sattabongkot, J Rothstein, Y Macareo, L Fracisco, S Bennett, K Magill, AJ Ohrt, C AF Deye, Gregory A. Gettayacamin, Montip Hansukjariya, Pranee Im-erbsin, Rawiwan Sattabongkot, Jetsumon Rothstein, Yarrow Macareo, Louis Fracisco, Susan Bennett, Kent Magill, Alan J. Ohrt, Colin TI Use of a Rhesus Plasmodium cynomolgi Model to Screen for Anti-Hypnozoite Activity of Pharmaceutical Substances SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID VIVAX MALARIA; CHLOROQUINE; PRIMAQUINE; QUININE; DRUG AB There remains a need for new drugs to prevent relapse of Plasmodium vivax or P. ovale infection. The relapsing primate malaria P. cynomolgi has been used for decades to assess drugs for anti-hypnozoite activity. After sporozoite inoculation and blood-stage cure of initial parasitemia with chloroquine, rhesus macaques were treated on subsequent relapses with chloroquine in conjunction with test regimens of approved drugs Tested drugs were selected for known liver or blood-stage activity and were tested alone or in conjunction with low-dose primaquine. Tinidazole and pyrazinamide prevented relapse when used in conjunction with chloroquine and low-dose primaquine. Triamterene and tinidazole administered without primaquine achieved radical cure in some animals. All other tested drugs or combinations failed to prevent relapse. The rhesus macaque P. cynomolgi model remains a useful tool for screening drugs with anti-hypnozoite activity. Tinidazole and pyrazinamide require further investigation as agents to enable dose reduction of primaquine. C1 [Deye, Gregory A.; Rothstein, Yarrow; Macareo, Louis; Fracisco, Susan; Bennett, Kent; Magill, Alan J.; Ohrt, Colin] Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. [Gettayacamin, Montip; Hansukjariya, Pranee; Im-erbsin, Rawiwan] Armed Forces Res Inst Med Sci, Dept Vet Med, Bangkok 10400, Thailand. [Sattabongkot, Jetsumon] Armed Forces Res Inst Med Sci, Dept Entomol, Bangkok 10400, Thailand. RP Deye, GA (reprint author), Walter Reed Army Inst Res, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM gregory.deye@gmail.com; montipg@AAALAC.org; praneeH@afrims.org; RawiwanI@afrims.org; Jetsumon@hotmail.com; yarrow.rothstein@us.army.mil; lmacareo@wrp-ksm.org; susan.fracisco@yahoo.com; kent.bennett@us.army.mil; alan.magill@darpa.mil; colin.ohrt@us.army.mil RI Bennett, Kent/K-2742-2012 FU US Army Medical Research and Materiel Command FX This study was supported by the Military Infectious Disease Research Program, US Army Medical Research and Materiel Command. NR 13 TC 15 Z9 15 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD JUN PY 2012 VL 86 IS 6 BP 931 EP 935 DI 10.4269/ajtmh.2012.11-0552 PG 5 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 952IH UT WOS:000304785700005 PM 22665596 ER PT J AU Conlan, JV Vongxay, K Jarman, RG Gibbons, RV Lunt, RA Fenwick, S Thompson, RCA Blacksell, SD AF Conlan, James V. Vongxay, Khamphouth Jarman, Richard G. Gibbons, Robert V. Lunt, Ross A. Fenwick, Stanley Thompson, R. C. Andrew Blacksell, Stuart D. TI Serologic Study of Pig-Associated Viral Zoonoses in Laos SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID HEPATITIS-E VIRUS; JAPANESE ENCEPHALITIS-VIRUS; IMMUNOGLOBULIN-M ANTIBODIES; NIPAH-VIRUS; HEMAGGLUTINATION-INHIBITION; GENETIC-CHARACTERIZATION; CEREBROSPINAL-FLUID; INFECTION; TRANSMISSION; CHINA AB We conducted a serologic survey of four high-priority pig-associated viral zoonoses, Japanese encephalitis virus (JEV), hepatitis E virus (HEV), Nipah virus (NiV), and swine influenza virus (SIV), in Laos. We collected blood from pigs at slaughter during May 2008 January 2009 in four northern provinces. Japanese encephalitis virus hemagglutination inhibition seroprevalence was 74.7% (95% confidence interval [CI] = 71.5-77.9%), JEV IgM seroprevalence was 2.3% (95% CI = 1.2-3.2%), and HEV seroprevalence was 21.1% (95% Cl = 18;1-24.0%). Antibodies to SIV were detected in 1.8% (95% CI = 0.8-2.8%) of pigs by screening enzyme-linked immunosorbent assay, and only subtype H3N2 was detected by hemagglutination inhibition in two animals with an inconclusive enzyme-linked immunosorbent assay result. No NiV antibody positive pigs were detected. Our evidence indicates that peak JEV and HEV transmission coincides with the start of the monsoonal wet season and poses the greatest risk for human infection. C1 [Conlan, James V.; Fenwick, Stanley; Thompson, R. C. Andrew] Murdoch Univ, Sch Vet & Biomed Sci, Murdoch, WA 6150, Australia. Minist Agr & Forestry, Dept Livestock & Fisheries, Natl Anim Hlth Ctr, Viangchan, Laos. [Jarman, Richard G.; Gibbons, Robert V.] Armed Forces Res Inst Med Sci, Dept Virol, US Army Med Component, Bangkok 10400, Thailand. [Lunt, Ross A.] Commonwealth Sci & Ind Res Org Livestock Ind, Australian Anim Hlth Lab, Geelong, Vic, Australia. [Blacksell, Stuart D.] Mahidol Univ, Fac Trop Med, Mahidol Oxford Trop Med Res Unit, Bangkok, Thailand. Univ Oxford, Nuffield Dept Clin Med, Ctr Clin Vaccinol & Trop Med, Oxford, England. RP Conlan, JV (reprint author), Murdoch Univ, Sch Vet & Biomed Sci, South St, Murdoch, WA 6150, Australia. EM j.conlan@murdoch.edu.au; kamputvongxay@yahoo.com; richard.jarman@afrims.org; robert.gibbons@afrims.org; ross.lunt@csiro.au; stanley_fenwick@dai.com; a.thompson@murdoch.edu.au; stuart@tropmedres.ac RI Lunt, Ross/I-4941-2013; OI Lunt, Ross/0000-0002-9630-8493; Blacksell, Stuart/0000-0001-6576-726X FU Australian Centre for International Agricultural Research [AH2006/161]; Murdoch University FX This study was supported by the Australian Centre for International Agricultural Research (project no. AH2006/161), and the laboratory work at the Armed Forces Research Institute of Medical Sciences was partially supported by U.S. Department of State Bioengagement Program. James V. Conlan was supported by a Murdoch University Research Studentship award. NR 58 TC 6 Z9 6 U1 1 U2 12 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD JUN PY 2012 VL 86 IS 6 BP 1077 EP 1084 DI 10.4269/ajtmh.2012.11-0195 PG 8 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 952IH UT WOS:000304785700031 PM 22665622 ER PT J AU Aygun, A Torrey, K Kumar, A Stephenson, LD AF Aygun, Aysegul Torrey, Kathryn Kumar, Ashok Stephenson, Larry D. TI Investigation of Factors Affecting Controlled Release from Photosensitive DMPC and DSPC Liposomes SO APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY LA English DT Article DE Liposome; DSPC; DMPC; Photo-induced destabilization; Controlled release; Lysis; Triggered liposomal release ID CHOLESTEROL CONTENT; IN-VITRO; STABILITY; PHOSPHOLIPIDS; PERMEABILITY; FORMULATION; ADDITIVES; MEMBRANES; DELIVERY; AGENTS AB An investigation of liposomes comprised of 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) or 1,2-distearoyl-sn-glycero-3-phosphocholine (DSPC) lipids with cholesterol and zinc phthalocyanine (ZnPC) revealed that several fundamental liposome properties are influenced by composition and by lipid-specific features. DMPC and DSPC liposomes were synthesized, and their compositional changes, encapsulation capacities, morphologies, and release properties were evaluated. In this research, liposome degradation, lysis, and content release were initiated by photolysis, i.e., rupture induced by exposure to light. A controlled release mechanism was created through the introduction of photosensitizers (i.e., ZnPC) embedded within the cholesterol-stabilized liposome membrane. The light wavelength and light exposure time accelerated photodegradation properties of DMPC liposomes compared to DSPC liposomes, which exhibited a slower release rate. Morphological changes in the liposomes were strongly influenced by light wavelength and light exposure time. For both the DMPC and DSPC liposomes, visible light with wavelengths in the red end of the spectrum and broad spectrum ambient lighting (400-700 nm) were more effective for lysis than UV-A light (365 nm). Heating liposomes to 100 A degrees C decreased the stability of liposomes compared to liposomes kept at room temperatures. In addition, the optimal lipid-to-cholesterol-to-photoactivator ratio that produced the most stable liposomes was determined. C1 [Aygun, Aysegul] Pertan Grp, Champaign, IL 61820 USA. [Aygun, Aysegul; Torrey, Kathryn; Kumar, Ashok; Stephenson, Larry D.] USA, Construct Engn Res Lab, Corps Engineers, Champaign, IL 61822 USA. RP Aygun, A (reprint author), Pertan Grp, 44 Main St,Suite 403, Champaign, IL 61820 USA. EM ayaygun@gmail.com FU US Army Corps of Engineer (USACE) FX We gratefully acknowledge the financial support from the US Army Corps of Engineer (USACE). This work was all done at Engineer Research and Development Center-Construction Engineering Research Laboratory (ERDC-CERL) and was funded by USACE 6.1 funds. The authors would also like to thank Ms. B. Mehnert for aid in editing the paper. NR 23 TC 7 Z9 7 U1 0 U2 24 PU HUMANA PRESS INC PI TOTOWA PA 999 RIVERVIEW DRIVE SUITE 208, TOTOWA, NJ 07512 USA SN 0273-2289 J9 APPL BIOCHEM BIOTECH JI Appl. Biochem. Biotechnol. PD JUN PY 2012 VL 167 IS 4 BP 743 EP 757 DI 10.1007/s12010-012-9724-6 PG 15 WC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology GA 954EU UT WOS:000304930200007 PM 22592778 ER PT J AU Taniuchi, M Walters, CC Gratz, J Maro, A Kumburu, H Serichantalergs, O Sethabutr, O Bodhidatta, L Kibiki, G Toney, DM Berkeley, L Nataro, JP Houpt, ER AF Taniuchi, Mami Walters, Carol C. Gratz, Jean Maro, Athanasia Kumburu, Happiness Serichantalergs, Oralak Sethabutr, Orntipa Bodhidatta, Ladaporn Kibiki, Gibson Toney, Denise M. Berkeley, Lynette Nataro, James P. Houpt, Eric R. TI Development of a multiplex polymerase chain reaction assay for diarrheagenic Escherichia coli and Shigella spp. and its evaluation on colonies, culture broths, and stool SO DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE LA English DT Article DE Multiplex PCR; Diarrheagenic E. coli; Luminex; Shigella; Enteroaggregative E. coli; Enterohemorrhagic E. coli; Enteropathogenic E. coli; Enterotoxigenic E. coli; Diarrhea; Enteroinvasive E. coli; PCR; Shiga toxin-producing E. coli; Virulence genes ID YOUNG-CHILDREN; PCR; GENE; IDENTIFICATION; INFECTIONS; AMPLIFICATION; TRAVELERS; VARIANTS; O157-H7; PROBE AB Detection of diarrheagenic Escherichia coli (DEC) typically depends on identification of virulence genes from stool cultures, not on stool itself. We developed a multiplex polymerase chain reaction (PCR) assay that detects key DEC virulence genes (stx1, stx2, eae, bfpA, ipaH, LT, STh, aaiC, aatA). The assay involved a multiplex PCR reaction followed by detection of amplicon(s) using Luminex beads. The assay was evaluated on over 100 colony and broth specimens. We then evaluated the assay using DNA extracted from stool, colony pools, and Gram-negative broths, using stool spiked with known quantities of DEC. Performance of the assay on stool DNA was most quantitative, while stool broth DNA offered the lowest limit of detection. The assay was prospectively evaluated on clinical specimens in Tanzania. Stool DNA yielded higher sensitivity than colony pools compared with broth DNA as the standard. We propose using this assay to screen for DEC directly in stool or stool broths. (C) 2012 Elsevier Inc. All rights reserved. C1 [Taniuchi, Mami; Gratz, Jean; Houpt, Eric R.] Univ Virginia, Div Infect Dis & Int Hlth, Charlottesville, VA 22908 USA. [Walters, Carol C.; Toney, Denise M.] Virginia Dept Gen Serv, Div Consolidated Lab Serv, Richmond, VA 23219 USA. [Gratz, Jean; Maro, Athanasia; Kumburu, Happiness; Kibiki, Gibson] Kilimanjaro Christian Med Ctr, Biotechnol Lab, Moshi, Tanzania. [Serichantalergs, Oralak; Sethabutr, Orntipa; Bodhidatta, Ladaporn] Armed Forces Res Inst Med Sci, Dept Enter Dis, Bangkok 10400, Thailand. [Berkeley, Lynette] Univ Maryland, Ctr Vaccine Dev, Baltimore, MD 21201 USA. [Nataro, James P.] Univ Virginia, Dept Pediat, Charlottesville, VA 22908 USA. RP Taniuchi, M (reprint author), Univ Virginia, Div Infect Dis & Int Hlth, POB 801340, Charlottesville, VA 22908 USA. EM mt2f@virginia.edu FU National Institute of Health [U01 AI075396-01]; Bill and Melinda Gates Foundation [51635] FX This work was supported by U01 AI075396-01 from the National Institute of Health and by the Study of Risk Factors for Malnutrition Using Molecular Genomic Tools Global Health Grant #51635 from the Bill and Melinda Gates Foundation. NR 43 TC 20 Z9 21 U1 1 U2 11 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0732-8893 J9 DIAGN MICR INFEC DIS JI Diagn. Microbiol. Infect. Dis. PD JUN PY 2012 VL 73 IS 2 BP 121 EP 128 DI 10.1016/j.diagmicrobio.2012.03.008 PG 8 WC Infectious Diseases; Microbiology SC Infectious Diseases; Microbiology GA 956PR UT WOS:000305102100003 PM 22541788 ER PT J AU Cafasso, D Schneider, P AF Cafasso, D. Schneider, P. TI Consideration of embolic protection devices during infrainguinal endovascular repair SO ITALIAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY LA English DT Article DE Peripheral arterial disease; Embolic protection devices; Embolism, cholesterol ID SUPERFICIAL FEMORAL-ARTERY; RENAL-ARTERY; VASCULAR INTERVENTIONS; DISTAL EMBOLIZATION; OCCLUSIVE DISEASE; LOWER-EXTREMITIES; EARLY EXPERIENCE; ANGIOPLASTY; REVASCULARIZATION; REGISTRY AB Embolic protection devices have the potential to make complex lower extremity endovascular interventions safer. The utility and success of distal embolic protection devices in the coronary and carotid vasculature have prompted the exploration as to whether such devices may evolve to prevent distal embolization in the lower extremity. There are no substantially powered, prospective, multicenter, randomized trials to prove or disprove the effectiveness and benefit of such devices over the associated risks. However, observational and experiential data are accumulating which provide clues as to the usefulness of this approach. This review presents an overview of the current literature as well as an argument for the use of distal embolic protection devices in selected patients during endovascular treatment of infrainguinal occlusive disease. The types of filters as well as the technique for filter use are described. Pitfalls and associated recommendations to over-come these circumstances are included. C1 [Cafasso, D.] Tripler Army Med Ctr, Dept Surg, Honolulu, HI 96859 USA. [Schneider, P.] Hawaii Permanente Med Grp, Div Vasc Therapy, Honolulu, HI USA. [Schneider, P.] Kaiser Fdn Hosp, Honolulu, HI USA. RP Cafasso, D (reprint author), Tripler Army Med Ctr, Dept Surg, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM Danielle.Cafasso@us.army.mil; Peter.Schneider@kp.org NR 29 TC 0 Z9 0 U1 0 U2 3 PU EDIZIONI MINERVA MEDICA PI TURIN PA CORSO BRAMANTE 83-85 INT JOURNALS DEPT., 10126 TURIN, ITALY SN 1824-4777 J9 ITAL J VASC ENDOVASC JI Ital. J. Vasc. Endovasc. Surg. PD JUN PY 2012 VL 19 IS 2 BP 87 EP 95 PG 9 WC Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 953TW UT WOS:000304897100005 ER PT J AU Moralez, G Romero, SA Rickards, CA Ryan, KL Convertino, VA Cooke, WH AF Moralez, Gilbert Romero, Steven A. Rickards, Caroline A. Ryan, Kathy L. Convertino, Victor A. Cooke, William H. TI Effects of dehydration on cerebrovascular control during standing after heavy resistance exercise SO JOURNAL OF APPLIED PHYSIOLOGY LA English DT Article DE hypohydration; cerebral blood flow; weight training; cerebrovascular control ID CEREBRAL-BLOOD-FLOW; DIURETIC-INDUCED DEHYDRATION; SYMPATHETIC-NERVE ACTIVITY; TILT-INDUCED SYNCOPE; ORTHOSTATIC STRESS; CARDIAC-OUTPUT; HUMANS; AUTOREGULATION; VELOCITY; RESPONSES AB Moralez G, Romero SA, Rickards CA, Ryan KL, Convertino VA, Cooke WH. Effects of dehydration on cerebrovascular control during standing after heavy resistance exercise. J Appl Physiol 112: 1875-1883, 2012. First published March 29, 2012; doi:10.1152/japplphysiol.01217.2011.-We tested the hypothesis that dehydration exacerbates reductions of middle cerebral artery blood velocity (MCAv) and alters cerebrovascular control during standing after heavy resistance exercise. Ten males participated in two trials under 1) euhydration (EUH) and 2) dehydration (DEH; fluid restriction + 40 mg furosemide). We recorded finger photoplethysmographic arterial pressure and MCAv (transcranial Doppler) during 10 min of standing immediately after high-intensity leg press exercise. Symptoms (e. g., lightheadedness) were ranked by subjects during standing (1-5 scale). Low-frequency (LF) oscillations of mean arterial pressure (MAP) and mean MCAv were calculated as indicators of cerebrovascular control. DEH reduced plasma volume by 11% (P = 0.002; calculated from hemoglobin and hematocrit). During the first 30 s of standing after exercise, subjects reported greater symptoms during DEH vs. EUH (P = 0.05), but these were mild and resolved at 60 s. While MAP decreased similarly between conditions immediately after standing, MCAv decreased more with DEH than EUH (P = 0.02). With prolonged standing under DEH, mean MCAv remained below baseline (P <= 0.01), and below EUH values (P <= 0.05). LF oscillations of MAP were higher for DEH at baseline and during the entire 10 min of stand after exercise (P <= 0.057), while LF oscillations in mean MCAv were distinguishable only at baseline and 5 min following stand (P = 0.05). Our results suggest that mean MCAv falls below a "symptomatic threshold" in the acute phase of standing after exercise during DEH, although symptoms were mild and transient. During the prolonged phase of standing, increases in LF MAP and mean MCAv oscillations with DEH may help to maintain cerebral perfusion despite absolute MCAv remaining below the symptomatic threshold. C1 [Moralez, Gilbert; Romero, Steven A.; Rickards, Caroline A.; Cooke, William H.] Univ Texas San Antonio, Dept Hlth & Kinesiol, Lab Appl Auton Neurophysiol, San Antonio, TX 78249 USA. [Ryan, Kathy L.; Convertino, Victor A.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Cooke, WH (reprint author), Univ Texas San Antonio, Dept Hlth & Kinesiol, Lab Appl Auton Neurophysiol, 1 UTSA Circle, San Antonio, TX 78249 USA. EM william.cooke@utsa.edu FU American College of Sports Medicine FX This study was funded by a Student Development Grant from the Texas Chapter of the American College of Sports Medicine (to G. Moralez). NR 46 TC 7 Z9 7 U1 3 U2 11 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 8750-7587 J9 J APPL PHYSIOL JI J. Appl. Physiol. PD JUN PY 2012 VL 112 IS 11 BP 1875 EP 1883 DI 10.1152/japplphysiol.01217.2011 PG 9 WC Physiology; Sport Sciences SC Physiology; Sport Sciences GA 952RS UT WOS:000304810500009 PM 22461441 ER PT J AU Ruhl, DS Ramsey, MJ Ruffin, DM AF Ruhl, Douglas S. Ramsey, Mitchell J. Ruffin, David M. TI A profound case of neurally mediated syncope with asystole after septoplasty SO JOURNAL OF CLINICAL ANESTHESIA LA English DT Article DE Asystole; Neurocardiogenic syncope; Vasovagal septoplasty ID HEAD-UP TILT; MALIGNANT VASOVAGAL SYNCOPE; GLOSSOPHARYNGEAL NEURALGIA; VAGOGLOSSOPHARYNGEAL NEURALGIA; CARDIAC SYNCOPE; TASK-FORCE; MANAGEMENT; DIAGNOSIS; THERAPY AB Vasovagal syncope (VVS) is an alarming yet benign condition that may present postoperatively for the first time in otherwise healthy patients. Although VVS is associated anecdotally with nasal manipulation, no data have been found to quantify this incidence with otolaryngology surgeries. We present a case of profound, recurrent syncope and documented asystole with an initial diagnosis of glossopharyngeal neuralgia. We conclude with a discussion of neurally mediated syncope particular to the perioperative setting. It is essential to recognize neurocardiogenic etiology to differentiate it from other more concerning causes of syncope and asystole. Published by Elsevier Inc. C1 [Ruhl, Douglas S.] Tripler Army Med Ctr, Attn MCHK DSH, Dept Otolaryngol Head & Neck Surg, Tamc, HI 96859 USA. [Ruffin, David M.] Tripler Army Med Ctr, Dept Anesthesiol, Tamc, HI 96859 USA. RP Ruhl, DS (reprint author), Tripler Army Med Ctr, Attn MCHK DSH, Dept Otolaryngol Head & Neck Surg, 1 Jarrett White Rd, Tamc, HI 96859 USA. EM douglas.ruhl@amedd.army.mil OI Ruhl, Douglas/0000-0002-7411-2385 NR 32 TC 0 Z9 0 U1 0 U2 1 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0952-8180 J9 J CLIN ANESTH JI J. Clin. Anesth. PD JUN PY 2012 VL 24 IS 4 BP 310 EP 314 DI 10.1016/j.jclinane.2011.10.006 PG 5 WC Anesthesiology SC Anesthesiology GA 951QS UT WOS:000304735700009 PM 22608586 ER PT J AU Parson, L Khalil, SM Waters, JP AF Parson, Larry Khalil, Syed M. Waters, Jeffrey P. TI An Introduction to the Technical Framework for the Gulf Regional Sediment Management Master Plan SO JOURNAL OF COASTAL RESEARCH LA English DT Article DE Regional sediment management; beneficial use; environmental restoration; environmental conservation; sediment management strategies; sediment processes; sediment transport; dredging activities; sediment planning AB Parson, L.; Khalil, S.M., and Waters, J.P., 2012. An introduction to the technical framework for the Gulf Regional Sediment Management Master Plan. In: Khalil, S.M., Parson, L.E., and Waters, J.P. (eds.), Technical Framework for the Gulf Regional Sediment Management Master Plan (GRSMMP), Journal of Coastal Research, Special Issue No. 60, 1-5. A partnership has been instituted through the Gulf of Mexico Alliance (GOMA) among the Gulf States to enhance the ecological and economic health of the Gulf of Mexico. Established under the GOMA, the Habitat Conservation and Restoration Team (HCRT) recognized that sediments are integral to and a critical resource in accomplishing the GOMA conservation and restoration objectives. As a result, the Gulf Regional Sediment Management Master Plan (GRSMMP) was initiated for managing sediment resources and corroborates the need for an understanding of regional sediment processes. The plan provides guidelines using the understanding of sediment dynamics to manage resources toward accomplishing environmental restoration, conservation, and preservation while enhancing abilities to make informed, management decisions. A key step in this process is the recognition of a technical framework that provides a foundation associated with regional sediment management processes essential for establishing management guidelines that balance sediment dynamics and available sediment resources with needs and that enhance abilities to make informed management decisions and develop regional strategies. Issues surrounding sediment management, both natural and dredged sediments, have a considerable impact on the ability to sustain coastal habitats. Sediment management must occur on a regional scale unencumbered by agency, state, or political boundaries. Guidelines and recommendations from this effort will aid the Gulf States in more effective management of sediment resources, recognizing they are a part of a regional system involving natural and man-made processes. The effort involves a range of state and federal agencies, as well as nongovernmental representatives. Thus, a technical framework for the GRSMMP was compiled/completed and submitted to the HCRT/GOMA. The decision was made to publish this document as peer-reviewed papers in a special issue of the Journal of Coastal Research for benefit of the global scientific community. In return, feedback in terms of review and comments will be beneficial for the team. C1 [Parson, Larry] USA, Corps Engineers, Mobile, AL 36602 USA. [Khalil, Syed M.] CPRA, Baton Rouge, LA 70801 USA. [Waters, Jeffrey P.] USA, Engn Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Parson, L (reprint author), USA, Corps Engineers, Mobile, AL 36602 USA. EM larry.e.parson@usace.army.mil; Syed.Khalil@la.gov; jeffrey.p.waters@usace.army.mil NR 2 TC 0 Z9 0 U1 2 U2 5 PU COASTAL EDUCATION & RESEARCH FOUNDATION PI LAWRENCE PA 810 EAST 10TH STREET, LAWRENCE, KS 66044 USA SN 0749-0208 J9 J COASTAL RES JI J. Coast. Res. PD SUM PY 2012 SI 60 BP 1 EP 5 DI 10.2112/SI_60_1 PG 5 WC Environmental Sciences; Geography, Physical; Geosciences, Multidisciplinary SC Environmental Sciences & Ecology; Physical Geography; Geology GA 950XH UT WOS:000304684700002 ER PT J AU Morang, A Waters, JP Khalil, SM AF Morang, Andrew Waters, Jeffrey P. Khalil, Syed M. TI Gulf of Mexico Regional Sediment Budget SO JOURNAL OF COASTAL RESEARCH LA English DT Article DE Planning tools; sediment management; sediment pathways; sediment budget ID MISSISSIPPI RIVER; ALABAMA AB Morang, A. M.; Waters, J. P., and Khalil, S. M., 2012. Gulf of Mexico regional sediment budget. In: Khalil, S.M., Parson, L.E., and Waters, J.P. (eds.), Technical Framework for the Gulf Regional Sediment Management Master Plan (GRSMMP), Journal of Coastal Research, Special Issue No. 60, 14-29. Development of dynamic regional sediment management (RSM) plans is needed for future planning, construction, and monitoring of wetland and barrier island restoration. Broadly speaking, RSM refers to the optimum use of various sediment resources (littoral, estuarine, and riverine) in an environmentally effective and economically feasible manner. Coordination of the supply and demand sides of sand resources in a comprehensive manner will be required as project planning develops and evolves. The sediment budget is a planning tool that provides an accounting of sediment sources, sinks, and pathways as well as engineering activities and sediment budgets have generally been characterized as conceptual, interim, and operational depending upon the quality of the data, the level of analysis, and the uncertainty associated with the volume fluxes in the sediment budget. This paper summarizes existing sediment budget data for the entire Northern Gulf of Mexico. The purpose of this work has been to compile available sediment budget data into a common geographic information system based data management framework in order to address various sediment management issues related to restoration around the Gulf of Mexico. The regional sediment budget is comprehensive and current through year end 2008. Within the coastal management community, there is an increasing awareness of the importance of reliable sediment budgets to inform sediment management decisions. However more work is needed to refine the sediment budget and provide its appropriate place in coastal management decisions. C1 [Morang, Andrew; Waters, Jeffrey P.] USA, Engn Res & Dev Ctr, Vicksburg, MS 39180 USA. [Khalil, Syed M.] CPRA, Baton Rouge, LA 70801 USA. RP Morang, A (reprint author), USA, Engn Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM andrew.morang@usace.army.mil NR 30 TC 1 Z9 1 U1 4 U2 16 PU COASTAL EDUCATION & RESEARCH FOUNDATION PI LAWRENCE PA 810 EAST 10TH STREET, LAWRENCE, KS 66044 USA SN 0749-0208 J9 J COASTAL RES JI J. Coast. Res. PD SUM PY 2012 SI 60 BP 14 EP 29 DI 10.2112/SI_60_3 PG 16 WC Environmental Sciences; Geography, Physical; Geosciences, Multidisciplinary SC Environmental Sciences & Ecology; Physical Geography; Geology GA 950XH UT WOS:000304684700004 ER PT J AU Parson, LE Swafford, R AF Parson, Larry E. Swafford, Russell TI Beneficial Use of Sediments from Dredging Activities in the Gulf of Mexico SO JOURNAL OF COASTAL RESEARCH LA English DT Article AB Parson, L.E. and Swafford, R., 2012. Beneficial use of sediments from dredging activities in the Gulf of Mexico. In: Khalil, S.M., Parson, L.E., and Waters, J.P. (eds.), Technical Framework for the Gulf Regional Sediment Management Master Plan (GRSMMP), Journal of Coastal Research, Special Issue No. 60, 45-50. Dredging activities are a potential source of sediment and should be considered in any conservation and restoration planning process. Wise use of sediment resources from dredging is integral to accomplishing the conservation and restoration initiatives and objectives being recommended under the Gulf of Mexico Alliance. Keeping dredged sediments within the natural system or using it in the construction of restoration projects can improve environmental conditions, provide storm damage protection, and contribute to habitat creation and restoration goals. Hundreds of millions of cubic yards of sediments are dredged each year from Gulf ports, harbors, and waterways, much of which could be used beneficially. Currently it is estimated that about 30% of all material dredged from federal channels in the Gulf states is used beneficially and very little of the privately funded dredging is used for beneficial purposes. The U.S. Army Corps of Engineers (USACE) conducts dredging under its navigation maintenance program and much of the dredging conducted is typically done on a scheduled and routine basis. Successful planning of beneficial-use projects utilizing USACE dredging necessitates the early coordination and work of multidisciplinary interagency teams on a regular basis. There is also a need to improve data access and management for dredging activities for use by project managers and planners. C1 [Parson, Larry E.] USA, Corps Engineers, Mobile, AL 36602 USA. [Swafford, Russell] Natl Marine Fisheries Serv, Galveston, TX 77551 USA. RP Parson, LE (reprint author), USA, Corps Engineers, Mobile, AL 36602 USA. EM larry.e.parson@usace.army.mil NR 9 TC 5 Z9 5 U1 1 U2 16 PU COASTAL EDUCATION & RESEARCH FOUNDATION PI LAWRENCE PA 810 EAST 10TH STREET, LAWRENCE, KS 66044 USA SN 0749-0208 J9 J COASTAL RES JI J. Coast. Res. PD SUM PY 2012 SI 60 BP 45 EP 50 DI 10.2112/SI_60_5 PG 6 WC Environmental Sciences; Geography, Physical; Geosciences, Multidisciplinary SC Environmental Sciences & Ecology; Physical Geography; Geology GA 950XH UT WOS:000304684700006 ER PT J AU Padgett, C Williams, K AF Padgett, Clint Williams, Klay TI Information Management Related to Regional Sediment Management in the Gulf of Mexico SO JOURNAL OF COASTAL RESEARCH LA English DT Article AB Padgett, C. and Williams, K., 2012. Information management related to regional sediment management in the Gulf of Mexico. In: Khalil, S.M., Parson, L.E., and Waters, J.P. (eds.), Technical Framework for the Gulf Regional Sediment Management Master Plan (GRSMMP), Journal of Coastal Research, Special Issue No. 60,66-71. Currently, a number of organizations across the Gulf Coast are simultaneously collecting and distributing proprietary data. However, if Gulf Regional Sediment Management Master Plan (GRSMMP) users are to perform analysis efficiently and make effective, educated decisions to support various coastal projects, collaboration and data sharing at all levels of government and among the numerous shareholders must be established. One method of doing this is the implementation of an enterprise geographic information system (EGIS) a geospatial technology infrastructure that delivers spatial information products, services, and standard data sets to all business elements and processes within and among organizations. The U.S. Army Corps of Engineers has developed and/or participated in a number of such enterprise GIS efforts, including the eCoastal, CE-Dredge, and Spatial Presentation Viewer programs. It is therefore proposed that the GRSMMP establish a firm data management plan and implement an organized, enterprise approach to data management through the use of Web Map Services (WMS). By including the publication of planned data acquisition, inventory of available offline data products, and direct access to organization flagship data sets, such a proposal would allow GRSMMP members to locate, connect to, view, and retrieve desirable data sets across many agencies, saving time and money previously dedicated to new data acquisition. C1 [Padgett, Clint; Williams, Klay] USA, Corps Engineers, Spatial Data Branch, Mobile, AL 36602 USA. RP Padgett, C (reprint author), USA, Corps Engineers, Spatial Data Branch, 109 St Joseph St,Room 7029, Mobile, AL 36602 USA. EM clint.padgett@usace.army.mil NR 0 TC 1 Z9 1 U1 0 U2 12 PU COASTAL EDUCATION & RESEARCH FOUNDATION PI LAWRENCE PA 810 EAST 10TH STREET, LAWRENCE, KS 66044 USA SN 0749-0208 J9 J COASTAL RES JI J. Coast. Res. PD SUM PY 2012 SI 60 BP 66 EP 71 DI 10.2112/SI_60_7 PG 6 WC Environmental Sciences; Geography, Physical; Geosciences, Multidisciplinary SC Environmental Sciences & Ecology; Physical Geography; Geology GA 950XH UT WOS:000304684700008 ER PT J AU Johnson, CI Mayer, RE AF Johnson, Cheryl I. Mayer, Richard E. TI An Eye Movement Analysis of the Spatial Contiguity Effect in Multimedia Learning SO JOURNAL OF EXPERIMENTAL PSYCHOLOGY-APPLIED LA English DT Article DE multimedia learning; eye tracking; spatial contiguity; transfer ID PRINT ADVERTISEMENTS; COGNITIVE LOAD; ILLUSTRATIONS; INFORMATION; TEXT; MODALITY; LOOKING; DESIGN AB In three studies, eye movements of participants were recorded while they viewed a single-slide multimedia presentation about how car brakes work. Some of the participants saw an integrated presentation in which each segment of words was presented near its corresponding area of the diagram (integrated group, Experiments 1 and 3) or an integrated presentation that also included additional labels identifying each part (integrated-with-labels group, Experiment 2), whereas others saw a separated presentation in which the words were presented as a paragraph below the diagrams (separated group, Experiments 1 and 2) or as a legend below the diagrams (legend group, Experiment 3). On measures of cognitive processing during learning, the integrated groups made significantly more eye-movements from text to diagram and vice versa (integrative transitions; d = 1.65 in Experiment 1, d = 0.85 in Experiment 2, and d = 1.44 in Experiment 3) and significantly more eye-movements from the text to the corresponding part of the diagram (corresponding transitions; d = 2.02 in Experiment 1 and d = 1.35 in Experiment 3) than the separated groups. On measures of learning outcome the integrated groups significantly outperformed the separated groups on transfer test score in Experiment 1(d = .80) and Experiment 2 (d = .73) but not in Experiment 3 (d = .35). Spatial contiguity encourages more attempts to integrate words and pictures and enables more successful integration of words and pictures during learning, which can result in meaningful learning outcomes. C1 [Johnson, Cheryl I.] US Army, Res Inst, Orlando, FL 32826 USA. [Mayer, Richard E.] Univ Calif Santa Barbara, Dept Psychol, Santa Barbara, CA 93106 USA. RP Johnson, CI (reprint author), US Army, Res Inst, 12350 Res Pkwy, Orlando, FL 32826 USA. EM cheryl.i.johnson@us.army.mil NR 39 TC 31 Z9 32 U1 10 U2 31 PU AMER PSYCHOLOGICAL ASSOC PI WASHINGTON PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA SN 1076-898X J9 J EXP PSYCHOL-APPL JI J. Exp. Psychol.-Appl. PD JUN PY 2012 VL 18 IS 2 BP 178 EP 191 DI 10.1037/a0026923 PG 14 WC Psychology, Applied SC Psychology GA 955TT UT WOS:000305044500004 PM 22309059 ER PT J AU Lambert, JH Karvetski, CW Spencer, DK Sotirin, BJ Liberi, DM Zaghloul, HH Koogler, JB Hunter, SL Goran, WD Ditmer, RD Linkov, I AF Lambert, James H. Karvetski, Christopher W. Spencer, David K. Sotirin, Barbara J. Liberi, Dawn M. Zaghloul, Hany H. Koogler, John B. Hunter, Samuel L. Goran, William D. Ditmer, Renae D. Linkov, Igor TI Prioritizing Infrastructure Investments in Afghanistan with Multiagency Stakeholders and Deep Uncertainty of Emergent Conditions SO JOURNAL OF INFRASTRUCTURE SYSTEMS LA English DT Article DE Decision making; Infrastructure; Risk management; Uncertainty principles; Sustainable development; Afghanistan; Investments ID DECISION-ANALYSIS; DELIBERATIVE METHOD; RISK; RANKING; SYSTEMS; FRAMEWORK; MANAGEMENT; PROJECTS AB The Afghanistan National Development Strategy identified billions of dollars of needs for transportation, water, energy, telecommunications, and other necessary infrastructure development for the rebuilding of Afghanistan. With economic sustainability as a primary aim, the coordination and prioritization of investments has been a challenge in part because of Afghanistan's volatile security situation along with the intricacies of the negotiating and coordinating efforts of numerous stakeholders. An understanding of the contributions of infrastructure systems and associated projects to the national development strategy is needed. This paper formulates a scenario-informed multicriteria approach to prioritize major project investments for infrastructure development subject to deep, nonprobabilistic uncertainties. The methods are inclusive of stakeholder values and accounts for deep uncertainties in governance, security, economy, environment, workforce, and other topics. The methods are applied in Afghanistan's Nangarhar province to assist in the selection among twenty-seven candidate infrastructure projects that are vulnerable to potential refugee immigration among other emergent conditions. The paper describes the relationships of selected projects to strategic goals while facilitating collaboration among government and nongovernment investors, donors, technologists, and other stakeholders. DOI: 10.1061/(ASCE)IS.1943-555X.0000078. (C) 2012 American Society of Civil Engineers. C1 [Linkov, Igor] USA, Corps Engineers, Engineer Res & Dev Ctr, Environm Lab, Concord, MA 01742 USA. [Lambert, James H.] Univ Virginia, Charlottesville, VA 22904 USA. [Karvetski, Christopher W.] George Mason Univ, Fairfax, VA 22030 USA. [Spencer, David K.] USA, Ft Leavenworth, KS USA. [Sotirin, Barbara J.] US Dept Def, Washington, DC 20305 USA. [Liberi, Dawn M.] US Agcy Int Dev, Washington, DC 20523 USA. [Zaghloul, Hany H.; Hunter, Samuel L.; Goran, William D.] USA, Corps Engineers, Engineer Res & Dev Ctr, Construct Engn Res Lab, Champaign, IL USA. [Koogler, John B.] US Dept State, Washington, DC 20520 USA. [Ditmer, Renae D.] STRATCON LLC, Woodbridge, VA USA. RP Linkov, I (reprint author), USA, Corps Engineers, Engineer Res & Dev Ctr, Environm Lab, 696 Virginia Rd, Concord, MA 01742 USA. EM lambert@virginia.edu; Igor.Linkov@usace.army.mil FU U.S. Army Corps of Engineers; Business Transformation Agency of the U.S. Department of Defense FX The effort described in this paper has been supported by the U.S. Army Corps of Engineers and by the Business Transformation Agency of the U.S. Department of Defense. The authors are grateful for the comments of the participants of a workshop on the Afghanistan Sustainable Infrastructure Plan that was convened early in the effort at the University Club, Washington, D.C. Permission was granted by the US Army Chief of Engineers to publish this information. The views and opinions expressed in this paper are those of the individual authors and not those of the US Department of State, US Army or other sponsor agencies. NR 57 TC 16 Z9 19 U1 3 U2 13 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 1076-0342 EI 1943-555X J9 J INFRASTRUCT SYST JI J. Infrastruct. Syst. PD JUN PY 2012 VL 18 IS 2 BP 155 EP 166 DI 10.1061/(ASCE)IS.1943-555X.0000078 PG 12 WC Engineering, Civil SC Engineering GA 952WP UT WOS:000304825900011 ER PT J AU Czeiter, E Mondello, S Kovacs, N Sandor, J Gabrielli, A Schmid, K Tortella, F Wang, KKW Hayes, RL Barzo, P Ezer, E Doczi, T Buki, A AF Czeiter, Endre Mondello, Stefania Kovacs, Noemi Sandor, Janos Gabrielli, Andrea Schmid, Kara Tortella, Frank Wang, Kevin K. W. Hayes, Ronald L. Barzo, Pal Ezer, Erzsebet Doczi, Tamas Buki, Andras TI Brain Injury Biomarkers May Improve the Predictive Power of the IMPACT Outcome Calculator SO JOURNAL OF NEUROTRAUMA LA English DT Article DE biomarkers; IMPACT calculator; outcome; prognostic models; traumatic brain injury ID SPECTRIN BREAKDOWN PRODUCTS; FIBRILLARY ACIDIC PROTEIN; NEURON-SPECIFIC ENOLASE; C-TERMINAL HYDROLASE; CEREBROSPINAL-FLUID; ADMISSION CHARACTERISTICS; PROGNOSTIC MODELS; HEAD-INJURY; DIAGNOSIS; CLASSIFICATION AB Outcome prediction following severe traumatic brain injury (sTBI) is a widely investigated field of research. A major breakthrough is represented by the IMPACT prognostic calculator based on admission data of more than 8500 patients. A growing body of scientific evidence has shown that clinically meaningful biomarkers, including glial fibrillary acidic protein (GFAP), ubiquitin C-terminal hydrolase-L1 (UCH-L1), and alpha II-spectrin breakdown product (SBDP145), could also contribute to outcome prediction. The present study was initiated to assess whether the addition of biomarkers to the IMPACT prognostic calculator could improve its predictive power. Forty-five sTBI patients (GCS score <= 8) from four different sites were investigated. We utilized the core model of the IMPACT calculator (age, GCS motor score, and reaction of pupils), and measured the level of GFAP, UCH-L1, and SBDP145 in serum and cerebrospinal fluid (CSF). The forecast and actual 6-month outcomes were compared by logistic regression analysis. The results of the core model itself, as well as serum values of GFAP and CSF levels of SBDP145, showed a significant correlation with the 6-month mortality using a univariate analysis. In the core model, the Nagelkerke R-2 value was 0.214. With multivariate analysis we were able to increase this predictive power with one additional biomarker (GFAP in CSF) to R-2 = 0.476, while the application of three biomarker levels (GFAP in CSF, GFAP in serum, and SBDP145 in CSF) increased the Nagelkerke R-2 to 0.700. Our preliminary results underline the importance of biomarkers in outcome prediction, and encourage further investigation to expand the predictive power of contemporary outcome calculators and prognostic models in TBI. C1 [Czeiter, Endre; Kovacs, Noemi; Ezer, Erzsebet; Doczi, Tamas; Buki, Andras] Univ Pecs, Dept Neurosurg, Sch Med, H-7623 Pecs, Hungary. [Czeiter, Endre] Univ Pecs, Dept Anat, Sch Med, H-7623 Pecs, Hungary. [Mondello, Stefania; Gabrielli, Andrea; Hayes, Ronald L.] Univ Florida, Dept Anesthesiol, Gainesville, FL USA. [Wang, Kevin K. W.] Univ Florida, Ctr Neuroprote & Biomarkers Res, Dept Psychiat, McKnight Brain Inst, Gainesville, FL USA. [Mondello, Stefania; Hayes, Ronald L.] Banyan Biomarkers Inc, Dept Clin Programs, Ctr Innovat Res, Alachua, FL USA. [Wang, Kevin K. W.] Banyan Biomarkers Inc, Dept Diagnost Res & Dev, Ctr Innovat Res, Alachua, FL USA. [Sandor, Janos] Univ Debrecen, Div Biostat & Epidemiol, Fac Publ Hlth, H-4012 Debrecen, Hungary. [Schmid, Kara; Tortella, Frank] Walter Reed Army Inst Res, Dept Appl Neurobiol, Div Psychiat & Neurosci, Silver Spring, MD USA. [Barzo, Pal] Univ Szeged, Dept Neurosurg, Fac Med, Szeged, Hungary. RP Czeiter, E (reprint author), Univ Pecs, Dept Neurosurg, Sch Med, 2 Ret St, H-7623 Pecs, Hungary. EM endre.czeiter@gmail.com RI Mondello, Stefania/A-1813-2012; Doczi, Tamas /C-5750-2009; Czeiter, Endre/B-1404-2009; OI Mondello, Stefania/0000-0002-8587-3614; Wang, Kevin/0000-0002-9343-6473 FU Department of Defense [DAMD17-03-1-0772, DAMD17-03-1-0066]; National Institutes of Health [R01-NS049175-01, R01-NS052831-01, R01-NS051431-01]; University of Florida [N00014-06-1-1029]; Developing Competitiveness of Universities in the South Transdanubian Region [SROP-4.2.1.B-10/2/KONV-2010-0002]; MTA-PTE Clinical Neuroscience MR Research Group; ETT [269/2009]; Banyan Biomarkers, Inc. FX This study was primarily sponsored by Department of Defense Award numbers DAMD17-03-1-0772 and DAMD17-03-1-0066; we also acknowledge additional funding support from the National Institutes of Health (R01-NS049175-01, R01-NS052831-01, and R01-NS051431-01), Navy grant no. N00014-06-1-1029 (University of Florida), and Developing Competitiveness of Universities in the South Transdanubian Region (SROP-4.2.1.B-10/2/KONV-2010-0002), as well as the MTA-PTE Clinical Neuroscience MR Research Group and ETT grant no. 269/2009.; Drs. Czeiter, Mondello, Kovacs, Gabrielli, Barzo, Ezer, and Buki are consultants for Banyan Biomarkers, Inc., and received consulting fees. Drs. Wang and Hayes own stock, receive royalties from, and are officers of Banyan Biomarkers Inc., and as such may benefit financially as a result of the outcomes of this research. No competing financial interests exist for Drs. Sandor, Schmid, Tortella, and Doczi. NR 39 TC 42 Z9 45 U1 0 U2 7 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 EI 1557-9042 J9 J NEUROTRAUM JI J. Neurotrauma PD JUN PY 2012 VL 29 IS 9 BP 1770 EP 1778 DI 10.1089/neu.2011.2127 PG 9 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA 954CN UT WOS:000304924000006 PM 22435839 ER PT J AU Peacock, ZS Kademani, D Le, AD Lee, JS Hale, RG Cunningham, LL AF Peacock, Zachary S. Kademani, Deepak Le, Anh D. Lee, Janice S. Hale, Robert G. Cunningham, Larry L., Jr. TI Proceedings From the 2011 American Association of Oral and Maxillofacial Surgeons Research Summit SO JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY LA English DT Editorial Material ID OBSTRUCTIVE SLEEP-APNEA; SQUAMOUS-CELL CARCINOMA; QUALITY-OF-LIFE; POSITIVE AIRWAY PRESSURE; LYMPH-NODE BIOPSY; HUMAN-PAPILLOMAVIRUS; HEART HEALTH; NECK-CANCER; RISK-FACTOR; CARDIOVASCULAR-DISEASE C1 [Cunningham, Larry L., Jr.] Univ Kentucky, Coll Dent, Div Oral & Maxillofacial Surg, Lexington, KY 40536 USA. [Peacock, Zachary S.] Massachusetts Gen Hosp, Dept Oral & Maxillofacial Surg, Boston, MA 02114 USA. [Peacock, Zachary S.] Harvard Univ, Sch Dent Med, Boston, MA 02115 USA. [Kademani, Deepak] Univ Minnesota, Sch Dent, Dept Oral & Maxillofacial Surg, Minneapolis, MN 55455 USA. [Le, Anh D.] Univ So Calif, Los Angeles, CA USA. [Lee, Janice S.] Univ Calif San Francisco, Dept Oral & Maxillofacial Surg, San Francisco, CA USA. [Hale, Robert G.] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. RP Cunningham, LL (reprint author), Univ Kentucky, Coll Dent, Div Oral & Maxillofacial Surg, 800 Rose St,D-508, Lexington, KY 40536 USA. EM llcunn2@email.uky.edu FU NIDCR NIH HHS [R13DE019744] NR 85 TC 1 Z9 1 U1 0 U2 1 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0278-2391 J9 J ORAL MAXIL SURG JI J. Oral Maxillofac. Surg. PD JUN PY 2012 VL 70 IS 6 BP 1271 EP 1279 DI 10.1016/j.joms.2012.01.029 PG 9 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA 950TS UT WOS:000304672700008 PM 22608814 ER PT J AU Foran, M Strickland, F Perkins, K Smith, JA AF Foran, Michael Strickland, Frank Perkins, Kimberley Smith, Julie Ann TI Excessive Intraoperative Bleeding With Chronic Energy Drink Consumption SO JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY LA English DT Article C1 [Foran, Michael; Strickland, Frank; Perkins, Kimberley] Walter Reed Army Med Ctr, Dept Oral & Maxillofacial Surg, Washington, DC 20307 USA. [Smith, Julie Ann] Oregon Hlth & Sci Univ, Dept Oral & Maxillofacial Surg, Portland, OR 97201 USA. RP Foran, M (reprint author), Walter Reed Army Med Ctr, Dept Oral & Maxillofacial Surg, 6900 Georgia Ave, Washington, DC 20307 USA. EM MichaelForanDMD@gmail.com NR 8 TC 3 Z9 3 U1 0 U2 1 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0278-2391 J9 J ORAL MAXIL SURG JI J. Oral Maxillofac. Surg. PD JUN PY 2012 VL 70 IS 6 BP 1439 EP 1441 DI 10.1016/j.joms.2011.03.067 PG 3 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA 950TS UT WOS:000304672700032 PM 21813226 ER PT J AU Teyhen, DS Shaffer, SW Lorenson, CL Halfpap, JP Donofry, DF Walker, MJ Dugan, JL Childs, JD AF Teyhen, Deydre S. Shaffer, Scott W. Lorenson, Chelsea L. Halfpap, Joshua P. Donofry, Dustin F. Walker, Michael J. Dugan, Jessica L. Childs, John D. TI The Functional Movement Screen: A Reliability Study SO JOURNAL OF ORTHOPAEDIC & SPORTS PHYSICAL THERAPY LA English DT Article DE injury prediction; injury prevention; injury risk; interrater; intrarater ID LOWER-EXTREMITY BIOMECHANICS; DYNAMIC STABILIZATION; INJURIES; PROGRAM; BALANCE; PREVENTION; PLAYERS AB STUDY DESIGN: Reliability study. OBJECTIVES: To determine intrarater test-retest and interrater reliability of the Functional Movement Screen (FMS) among novice raters. BACKGROUND: The FMS is used by various examiners to assess movement and predict time-loss injuries in diverse populations (eg, youth to professional athletes, firefighters, military service members) of active participants. Unfortunately, critical analysis of the reliability of the FMS is currently limited to 1 sample of active college-age participants. METHODS: Sixty-four active-duty service members (mean +/- SD age, 25.2 +/- 3.8 years; body mass index, 25.1 +/- 3.1 kg/m(2)) without a history of injury were enrolled. Participants completed the 7 component tests of the FMS in a counterbalanced order. Each component test was scored on an ordinal scale (0 to 3 points), resulting in a composite score ranging from 0 to 21 points. Intrarater test-retest reliability was assessed between baseline scores and those obtained with repeated testing performed 48 to 72 hours later. Interrater reliability was based on the assessment from 2 raters, selected from a pool of 8 novice raters, who assessed the same movements on day 2 simultaneously. Descriptive statistics, weighted kappa (kappa(w)), and percent agreement were calculated on component scores. Intraclass correlation coefficients (ICCs), standard error of the measurement, minimal detectable change (MDC95), and associated 95% confidence intervals (CIs) were calculated on composite scores. RESULTS: The average +/- SD score on the FMS was 15.7 +/- 0.2 points, with 15.6% (n = 10) of the participants scoring less than or equal to 14 points, the recommended cutoff for predicting time-loss injuries. The intrarater test-retest and interrater reliability of the FMS composite score resulted in an ICC3.1 of 0.76(95% CI: 0.63, 0.85) and an ICC2.1 of 0.74 (95% CI: 0.60, 0.83), respectively. The standard error of the measurement of the composite test was within 1 point, and the MDC95 values were 2.1 and 2.5 points on the 21-point scale for interrater and intrarater reliability, respectively. The interrater agreement of the component scores ranged from moderate to excellent (kappa(w) = 0.45-0.82). CONCLUSION: Among novice raters, the FMS composite score demonstrated moderate to good interrater and intrarater reliability, with acceptable levels of measurement error. The measures of reliability and measurement error were similar for both intrarater reliability that repeated the assessment of the movement patterns over a 48- to-72-hour period and interrater reliability that had 2 raters assess the same movement pattern simultaneously. The interrater agreement of the FMS component scores was good to excellent for the push-up, quadruped, shoulder mobility, straight leg raise, squat, hurdle, and lunge. Only 15.6% (n = 10) of the participants were identified to be at risk for injury based on previously published cutoff values. J Orthop Sports Phys Ther 2012;42(6):530-540, Epub 14 May 2012. doi:10.2519/jospt.2012.3838 C1 [Teyhen, Deydre S.; Shaffer, Scott W.; Lorenson, Chelsea L.; Halfpap, Joshua P.; Donofry, Dustin F.; Walker, Michael J.; Childs, John D.] USA, Baylor Univ, Ft Sam Houston, TX 78234 USA. [Teyhen, Deydre S.] USA, Publ Hlth Command Reg S, Ft Sam Houston, TX USA. [Dugan, Jessica L.] TRUE Res Fdn, San Antonio, TX USA. [Childs, John D.] Keesler Air Force Base, Med Grp 81, Dept Phys Therapy MSGS SGCUY, Biloxi, MS USA. RP Teyhen, DS (reprint author), USA, Baylor Univ, 3151 Scott Rd,Room 1303,ATTN MCCS HGE PT, Ft Sam Houston, TX 78234 USA. EM dteyhen@gmail.com NR 25 TC 60 Z9 61 U1 5 U2 74 PU J O S P T, PI ALEXANDRIA PA 1111 NORTH FAIRFAX ST, STE 100, ALEXANDRIA, VA 22314-1436 USA SN 0190-6011 J9 J ORTHOP SPORT PHYS JI J. Orthop. Sports Phys. Ther. PD JUN PY 2012 VL 42 IS 6 BP 530 EP 540 DI 10.2519/jospt.2012.3838 PG 11 WC Orthopedics; Rehabilitation; Sport Sciences SC Orthopedics; Rehabilitation; Sport Sciences GA 952IO UT WOS:000304786400007 PM 22585621 ER PT J AU Lieberman, HR Stavinoha, T McGraw, S White, A Hadden, L Marriott, BP AF Lieberman, Harris R. Stavinoha, Trisha McGraw, Susan White, Alan Hadden, Louise Marriott, Bernadette P. TI Caffeine Use among Active Duty US Army Soldiers SO JOURNAL OF THE ACADEMY OF NUTRITION AND DIETETICS LA English DT Article DE Energy drink; Coffee; Tea; Cola ID COGNITIVE PERFORMANCE; UNITED-STATES; CONSUMPTION; COFFEE; MOOD; VIGILANCE; OPERATIONS; ALERTNESS; DRINKS; WOMEN AB Eighty-percent of the US adult population regularly consumes caffeine, but limited information is available on the extent and patterns of use. Caffeine use is a public health issue and its risks and benefits are regularly considered in scientific literature and the lay media. Recently, new caffeine-containing products have been introduced and are widely available on Army bases and are added to rations to maintain cognitive performance. This study surveyed caffeine consumption and demographic characteristics in 990 US Army soldiers. Data were weighted by age, sex, rank, and Special Forces status. Total caffeine intake and intake from specific products were estimated. Logistic regression was used to examine relationships between caffeine use and soldier demographic and lifestyle characteristics. Eighty-two percent of soldiers consumed caffeine at least once a week. Mean daily caffeine consumption was 285 mg/day (347 mg/day among regular caffeine consumers). Male soldiers consumed, on average, 303 mg/day and females 163 mg/day (regular consumers: 365 mg/day for male soldiers, 216 mg/day for female soldiers). Coffee was the main source of caffeine intake. Among young males, energy drinks were the largest source of caffeine intake, but their intake was not greater than older males. Regression analysis indicated an association of higher caffeine intake with male sex, white race, and tobacco use (P < 0.01). Most soldiers consume caffeine in levels accepted as safe, but some consume greater quantities than recommended, although definitive information on safe upper limits of caffeine intake is not available. Labels of caffeine-containing products should provide caffeine content so individuals can make informed decisions. J Acad Nutr Diet 2012;112:902-912. C1 [Lieberman, Harris R.; Stavinoha, Trisha; McGraw, Susan] USA, Environm Med Res Inst, Mil Nutr Div, Natick, MA 01760 USA. [Stavinoha, Trisha] Evans Community Hosp, Performance Nutr Serv, Ft Carson, CO USA. [White, Alan; Marriott, Bernadette P.] ABT Associates Inc, Durham, NC USA. [Hadden, Louise] ABT Associates Inc, Cambridge, MA 02138 USA. [Marriott, Bernadette P.] Univ S Carolina, Dept Psychiat, Columbia, SC 29208 USA. RP Lieberman, HR (reprint author), USA, Environm Med Res Inst, Mil Nutr Div, Natick, MA 01760 USA. EM harris.lieberman@us.army.mil FU US Army Medical Research and Material Command; Department of Defense Center Alliance for Dietary Supplement Research FX Support for this research was provided by the US Army Medical Research and Material Command and the Department of Defense Center Alliance for Dietary Supplement Research. NR 44 TC 20 Z9 21 U1 0 U2 14 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 2212-2672 J9 J ACAD NUTR DIET JI J. Acad. Nutr. Diet. PD JUN PY 2012 VL 112 IS 6 BP 902 EP 912 DI 10.1016/j.jand.2012.02.001 PG 11 WC Nutrition & Dietetics SC Nutrition & Dietetics GA 951QU UT WOS:000304735900015 PM 22709816 ER PT J AU Smith, GL Pulskamp, JS Sanchez, LM Potrepka, DM Proie, RM Ivanov, TG Rudy, RQ Nothwang, WD Bedair, SS Meyer, CD Polcawich, RG AF Smith, Gabriel L. Pulskamp, Jeffrey S. Sanchez, Luz M. Potrepka, Daniel M. Proie, Robert M. Ivanov, Tony G. Rudy, Ryan Q. Nothwang, William D. Bedair, Sarah S. Meyer, Christopher D. Polcawich, Ronald G. TI PZT-Based Piezoelectric MEMS Technology SO JOURNAL OF THE AMERICAN CERAMIC SOCIETY LA English DT Article ID TITANATE THIN-FILMS; ACTUATORS; CAPACITORS; RADIATION AB This review article presents recent advancements in the design and fabrication of thin-film (<3 mu m) lead zirconate titanate (PZT) microelectromechanical system (MEMS) devices. The article covers techniques for optimizing highly (001)/(100) oriented chemical solution deposited PZT films to achieve improved piezoelectric coefficients. These PZT films combined with surface and bulk micromachining techniques are fabricated into actuators and transducers for radio frequency (RF) switches, nanomechanical logic, resonators, and power transformers for use in communication systems and phased-array radar. In addition, the large relative displacements generated by PZT thin films have been used to demonstrate mechanical mobility in MEMS devices, including insect-inspired flight actuators and ultrasonic traveling wave motors. In conjunction with actuation, PZT films are being developed for feedback sensors for the integrated control of insect-inspired robots. C1 [Smith, Gabriel L.; Pulskamp, Jeffrey S.; Sanchez, Luz M.; Potrepka, Daniel M.; Proie, Robert M.; Ivanov, Tony G.; Rudy, Ryan Q.; Nothwang, William D.; Bedair, Sarah S.; Meyer, Christopher D.; Polcawich, Ronald G.] USA, Sensors & Electron Devices Directorate, Res Lab, Adelphi, MD 20783 USA. RP Smith, GL (reprint author), USA, Sensors & Electron Devices Directorate, Res Lab, Adelphi, MD 20783 USA. EM gabe.smith@us.army.mil RI Bedair, Sarah/D-9130-2013; OI Potrepka, Daniel/0000-0002-0528-1038 NR 57 TC 45 Z9 46 U1 10 U2 102 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0002-7820 EI 1551-2916 J9 J AM CERAM SOC JI J. Am. Ceram. Soc. PD JUN PY 2012 VL 95 IS 6 BP 1777 EP 1792 DI 10.1111/j.1551-2916.2012.05155.x PG 16 WC Materials Science, Ceramics SC Materials Science GA 952BU UT WOS:000304765500001 ER PT J AU Sutorik, AC Gilde, G Cooper, C Wright, J Hilton, C AF Sutorik, Anthony C. Gilde, Gary Cooper, Christopher Wright, Jared Hilton, Corydon TI The Effect of Varied Amounts of LiF Sintering Aid on the Transparency of Alumina Rich Spinel Ceramic with the Composition MgO center dot 1.5 Al2O3 SO JOURNAL OF THE AMERICAN CERAMIC SOCIETY LA English DT Article ID MICROSTRUCTURE DEVELOPMENT AB Magnesium aluminate spinel with the alumina rich composition MgO center dot 1.5 Al2O3 has been prepared as a transparent polycrystalline ceramic with average in-line transmission at 550 nm of 83.3 +/- 0.9% and >80% throughout the visible spectrum. This finding significantly increases the compositional range over which polycrystalline magnesium aluminates can be prepared as fully dense ceramics with high transparency to visible light. Starting powders are prepared from combinations of high purity Mg(OH)(2) and gamma-Al2O3 thoroughly mixed in an aqueous slurry, and the solids are collected, dried, calcined, mixed with LiF sintering aid, and sieved. The powders are sintered into dense ceramics by hot pressing at 1600 degrees C under vacuum and 20 MPa uniaxial load, followed by hot isostatic pressing at 1850 degrees C under 200 MPa Ar. The crucial parameter for forming highly transparent MgO center dot 1.5 Al2O3 ceramic from this procedure is to hold the amount of LiF to 0.25 wt%. C1 [Sutorik, Anthony C.; Gilde, Gary; Cooper, Christopher] USA, Res Lab, Attn RDRL WMM E, Aberdeen Proving Ground, MD 21005 USA. [Wright, Jared] UICTS Bowhead Sci & Technol LLC, Belcamp, MD 21017 USA. [Hilton, Corydon] Oak Ridge Inst Sci & Educ, Oak Ridge, TN 37831 USA. RP Sutorik, AC (reprint author), USA, Res Lab, Attn RDRL WMM E, Bldg 4600, Aberdeen Proving Ground, MD 21005 USA. EM anthony.sutorik1@us.army.mil NR 22 TC 6 Z9 6 U1 1 U2 21 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0002-7820 J9 J AM CERAM SOC JI J. Am. Ceram. Soc. PD JUN PY 2012 VL 95 IS 6 BP 1807 EP 1810 DI 10.1111/j.1551-2916.2012.05217.x PG 4 WC Materials Science, Ceramics SC Materials Science GA 952BU UT WOS:000304765500006 ER PT J AU Kim, HC Bellies, GA Kim, MS Chong, ST Lee, DK Park, JY Yeh, JY Klein, TA AF Kim, Heung Chul Bellies, Glenn A. Kim, Myung-Soon Chong, Sung-Tae Lee, Dong-Kyu Park, Jee-Yong Yeh, Jung-Yong Klein, Terry A. TI Seasonal Abundance of Biting Midges, Culicoides spp. (Diptera: Ceratopogonidae), Collected at Cowsheds in the Southern Part of the Republic of Korea SO KOREAN JOURNAL OF PARASITOLOGY LA English DT Article DE Culicoides punctatus; Culicoides arakawae; biting midge; seasonal abundance ID JAPAN; ARBOVIRUSES; VIRUS AB Black light traps were used to measure the seasonal and geographical distribution of Culicoides spp. (biting midges or no-see-urns) at 9 cowsheds in the southern half of the Republic of Korea (ROK) from June through October 2010. A total of 25,242 Culicoides females (24,852; 98.5%) and males (390; 1.5%) comprising of 9 species were collected. The most commonly collected species was Culicoides punctatus (73.0%) followed by C. arakawae (25.7%), while the remaining 7 species accounted for <1.0% of all Culicoides spp. collected. The mean number of Culicoides spp. collected per trap night (Trap Index [TI]) was highest for C. punctatus (409.3), followed by C. arakawae (144.2), C. tainanus (4.1), C. oxystoma (1.2), C. circumscriptus (0.7), C. homotomus (0.6), C. erairai (0.4), C. kibunensis (0.3), and C. nipponensis (0.04). Peak TIs were observed for C. punctatus (1,188.7) and C. arakawae (539.0) during July and August, respectively. C. punctatus and C. arakawae have been implicated in the transmission of arboviruses and other pathogens of veterinary importance that adversely impact on animal and bird husbandry. C1 [Klein, Terry A.] 65th Med Brigade US Army MEDDAC Korea, Unit 15281, Seoul, South Korea. [Kim, Heung Chul; Kim, Myung-Soon; Chong, Sung-Tae] 168th Multifunct Med Battal, Med Detachment 5, Med Brigade 65, Unit 15247, Seoul, South Korea. [Bellies, Glenn A.] Dept Agr Fisheries & Forestry, Dept Agr Fisheries & Forestry, Winnellie, NT 0821, Australia. [Lee, Dong-Kyu] Kosin Univ, Dept Hlth & Environm, Pusan 606701, South Korea. [Park, Jee-Yong; Yeh, Jung-Yong] Anim Plant & Fisheries Quaentine & Inspect Agcy, Foreign Anim Dis Div, Anyang 430016, South Korea. [Kim, Heung Chul; Kim, Myung-Soon; Chong, Sung-Tae] 65th Med Brigade, Unit 15247, Multifunct Med Battal, Seoul 962055247, South Korea. RP Klein, TA (reprint author), 65th Med Brigade US Army MEDDAC Korea, Unit 15281, Seoul, South Korea. EM terry.klein@us.army.mil RI Valle, Ruben/A-7512-2013 FU Uniformed Services University, Bethesda, Maryland, USA; AFHSC-GEIS, Silver Spring, Maryland, USA; National Center for Medical Intelligence; 65th Medical Brigade, ROK FX We thank Hyun-Doo Kim, and Joo-Oh Kang, Kosin University, for their assistance in conducting Culicoides collections. We also thank Dr. Joel Gaydos, Armed Forces Health Surveillance Center, Global Emerging Infections Surveillance and Response System (AFHSC-GEIS), Silver Spring, Maryland, USA, for his administrative and technical support. This work was supported, as part of the Japanese encephalitis and malaria surveillance programs, through the joint partnership between the Uniformed Services University, Bethesda, Maryland, USA, the AFHSC-GEIS, Silver Spring, Maryland, USA, the National Center for Medical Intelligence, and the 65th Medical Brigade, ROK. The views expressed are those of the authors and should not be construed to represent the positions of the US Department of the Army or Department of Defense. NR 31 TC 5 Z9 5 U1 0 U2 2 PU KOREAN SOC PARASITOLOGY, SEOUL NATL UNIV COLL MEDI PI SEOUL PA DEPT PARASITOLOGY, SEOUL, 00000, SOUTH KOREA SN 0023-4001 J9 KOREAN J PARASITOL JI Korean J. Parasitol. PD JUN PY 2012 VL 50 IS 2 BP 127 EP 131 DI 10.3347/kjp.2012.50.2.127 PG 5 WC Parasitology SC Parasitology GA 955TX UT WOS:000305044900005 PM 22711923 ER PT J AU Kelly, WF Cuneo, BM Shimeall, WT AF Kelly, William F. Cuneo, Brian M. Shimeall, William T. TI Merging Cultures and Curriculum: An Anonymous Survey of Army and Navy Physicians Before the New Walter Reed Bethesda Internal Medicine Residency Program SO MILITARY MEDICINE LA English DT Editorial Material ID MERGER; INTEGRATION; EDUCATION C1 [Kelly, William F.] Uniformed Serv Univ Hlth Sci, Dept Med, Educ Programs, Bethesda, MD 20814 USA. [Cuneo, Brian M.] Walter Reed Army Med Ctr, Internal Med Program, Washington, DC 20307 USA. [Shimeall, William T.] Natl Naval Med Ctr, Internal Med Program, Bethesda, MD 20889 USA. RP Kelly, WF (reprint author), Uniformed Serv Univ Hlth Sci, Dept Med, Educ Programs, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA. NR 8 TC 1 Z9 1 U1 0 U2 1 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD JUN PY 2012 VL 177 IS 6 BP 624 EP 626 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA 955QP UT WOS:000305036300002 PM 22730835 ER PT J AU Hanson, JA Haub, MD Walker, JJ Johnston, DT Goff, BSN Dretsch, MN AF Hanson, Jennifer A. Haub, Mark D. Walker, Jennifer J. Johnston, Daniel T. Goff, Briana S. Nelson Dretsch, Michael N. TI Attention Deficit Hyperactivity Disorder Subtypes and Their Relation to Cognitive Functioning, Mood States, and Combat Stress Symptomatology in Deploying US Soldiers SO MILITARY MEDICINE LA English DT Article ID REPORT SCALE ASRS; ADULT ADHD; PERFORMANCE; PREVALENCE; MEDICATION; SYMPTOMS; VALIDITY; SERVICE; MEMBERS; INJURY AB Objectives: To explore the relationship between adult attention deficit hyperactivity disorder (ADHD) subtypes and neuropsychological functioning among U.S. soldiers. Methods: Deploying soldiers (N = 260) completed The World Health Organization Adult ADHD Self-Report Scale (ASRS) Screener. Cognitive tests, a deployment health::-history questionnaire, and the post-traumatic stress disorder (PTSD) Checklist-Military Version were completed by subsamples of available participants. Results: The prevalence of positive ASRS screens was 10.4%. ASRS scores were correlated with PTSD avoidance (n = 63, rho = 0.37, p = 0.003), hyperarousal (n = 63, rho = 0.25, p = 0.047), and total PTSD scores (n = 62, rho = 0.33, p = 0.009); and all six moods (e.g., anger, anxiety) scale scores (n = 110; rho = -0.37 to 0.43). ASRS was also correlated with scores on the match-to-sample (n = 110, p = 0.23, p = 0.014) and emotional,Stroop (n = 108, rho = 0.23, p = 0.016) tasks. In addition, a differential pattern between subtypes of ADHD was noted with regard to cognitive functioning, mood, and combat stress symptomatology. Conclusions: Although the results are :preliminary given the sample size, the prevalence and comorbidities of ADHD appear to be similar among military and nonmilitary populations. C1 [Hanson, Jennifer A.; Haub, Mark D.] Kansas State Univ, Dept Human Nutr, Manhattan, KS 66506 USA. [Walker, Jennifer J.] Schofield Barracks Hlth Clin, Clin Serv, Schofield Barracks, HI 96786 USA. [Johnston, Daniel T.] Comprehens Soldier Fitness, Washington, DC 20310 USA. [Goff, Briana S. Nelson] Kansas State Univ, Inst Hlth & Secur Mil Families, Manhattan, KS 66506 USA. [Dretsch, Michael N.] USA, Cognit Assessment & Diagnost Branch, Aeromed Res Lab, Ft Rucker, AL 36362 USA. RP Hanson, JA (reprint author), Kansas State Univ, Dept Human Nutr, 212 Justin Hall, Manhattan, KS 66506 USA. OI Hanson, Jennifer /0000-0003-0437-6489 FU American Dietetic Association Foundation; Kansas State University Research Foundation; United Sorghum Check-Off Program; NutriJoy; Coca-Cola; Penford Foods; VTT (Finland); USDA; Cargill; University of Nebraska Lincoln; Texas AM University; Midwest Advanced Food Manufacturing Alliance FX We would like to thank the military leadership and the soldiers for their support and participation. This study was funded in part by the Herbert D and Nylda Gemple Research Award from the American Dietetic Association Foundation. CPT Jennifer A. Hanson was the recipient of the Kansas State University Research Foundation Fellowship Award. She also received partial support from the University of Nebraska Impact of Sustagrain Barley Grant and Nutrijoy. This work was completed as part of her dissertation. Dr. Mark D. Haub has received funding (unrelated to this project) over the past 36 months from the United Sorghum Check-Off Program, NutriJoy, Coca-Cola, Penford Foods, VTT (Finland), USDA National Needs Fellowship, Cargill, University of Nebraska Lincoln, Texas A&M University, Midwest Advanced Food Manufacturing Alliance, and USDA Hatch Project. NR 30 TC 10 Z9 10 U1 1 U2 7 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD JUN PY 2012 VL 177 IS 6 BP 655 EP 662 PG 8 WC Medicine, General & Internal SC General & Internal Medicine GA 955QP UT WOS:000305036300007 PM 22730840 ER PT J AU Spiering, BA Walker, LA Hendrickson, NR Simpson, K Harman, EA Allison, SC Sharp, MA AF Spiering, Barry A. Walker, Leila A. Hendrickson, Nathan R. Simpson, Kathleen Harman, Everett A. Allison, Stephen C. Sharp, Marilyn A. TI Reliability of Military-Relevant Tests Designed to Assess Soldier Readiness for Occupational and Combat-Related Duties SO MILITARY MEDICINE LA English DT Article ID PHYSICAL PERFORMANCE TESTS; MATERIAL-HANDLING ABILITY; BRITISH-ARMY RECRUITS; STATISTICAL-METHODS; RESISTANCE; FITNESS; CRITERION; PERSONNEL; TASKS AB The purpose of this study was to determine the reliability of military-relevant tests: designed to assess soldier readiness. Forty-seven soldiers (46 men, 1 woman; 22 +/- 3 years; 80.4 +/- 11.7 kg) performed each of seven soldier readiness tests on four different occasions over the course of 8 weeks. The soldier readiness tests were: (I) 3.2-km load carriage (LC) time-trial, (2) running long jump (RLJ), (3) one-repetition maximum box lift (IRMBL), (4) 10-minute repetitive box lift and carry (RBLC), (5) simulated victim rescue (VR), (6) mock grenade throw (CT) for accuracy, and (7) simulated combat rushes (CR). Repeated measures analysis of variance revealed significant learning effects for IRMBL, RBLC, and GT; these tests required two (IRMBL and RBLC) or three (CT) trials to obtain statistically stable values. The intraclass correlation coefficient was 0.78 to 0.89 for all tests. LC, IRMBL, RBLC, CR, and RLJ all demonstrated standard error of measurement values that were 3% to 5%, whereas VR and GT were 9% and 36%, respectively. In conclusion, the IRMBL, RBLC, and CT tests required familiarization before a stable value was obtained. The LC, IRMBL, RBLC, CR, and RU tests (and, to a lesser degree, the VR test) demonstrated reasonably acceptable levels of reliability and measurement error, whereas the CT test did not. C1 [Spiering, Barry A.; Walker, Leila A.; Hendrickson, Nathan R.; Simpson, Kathleen; Harman, Everett A.; Allison, Stephen C.; Sharp, Marilyn A.] USA, Environm Med Res Inst, Mil Performance Div, Natick, MA 01760 USA. RP Spiering, BA (reprint author), USA, Environm Med Res Inst, Mil Performance Div, 15 Kansas St,Bldg 42, Natick, MA 01760 USA. FU Army Medical Research and Materiel Command FX Technical assistance in developing the testing equipment and procedures was skillfully provided by Mr. Peter Frykman. This study was supported by core funding from the Army Medical Research and Materiel Command. NR 17 TC 3 Z9 3 U1 1 U2 6 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD JUN PY 2012 VL 177 IS 6 BP 663 EP 668 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA 955QP UT WOS:000305036300008 PM 22730841 ER PT J AU Paolino, KM Henry, JA Hospenthal, DR Wortmann, GW Hartzell, JD AF Paolino, Kristopher M. Henry, James A. Hospenthal, Duane R. Wortmann, Glenn W. Hartzell, Joshua D. TI Invasive Fungal Infections Following Combat-Related Injury SO MILITARY MEDICINE LA English DT Article ID TRAUMA; IRAQ; ZYGOMYCOSIS AB Invasive mold infections are a rare complication of traumatic wounds. We examined the incidence and outcomes of these infections in combat wounds. A retrospective chart review from March 2002 through July 2008 of U.S. soldiers returning from Iraq and Afghanistan with traumatic wounds was performed. A confirmed fungal wound infection was defined as growth of a known pathogenic mold and visualization of fungal elements on histopathology. Six cases were identified for an incidence of 0.4 cases/1,000 admissions. The incidence of invasive mold infections increased over time (p = 0.008) with a peak of 5.2 cases/1,000 admissions in 2007. Isolated molds included Aspergillus (n = 4), Bipolaris (n = 2), and I each Mucor and Absidia. All patients were male with a mean age of 22. Blast (n = 5) and gunshot wound (n = 1) were the sources of injury. All patients had fever (mean 39.4 degrees C) and leukocytosis (mean white blood cell count 25 x 10(3)/mu L). The average acute physiology and chronic health evaluation II score was 22. All patients received antifungal agents, surgical debridement, and 3 required amputation revision. Average length of stay was 97 days. There were no deaths. Invasive mold infections are a rare complication of combat wounds but are associated with significant morbidity and may be increasing in frequency. C1 [Paolino, Kristopher M.] Walter Reed Army Inst Res, Dept Clin Trials, Silver Spring, MD 20910 USA. [Henry, James A.; Wortmann, Glenn W.; Hartzell, Joshua D.] Walter Reed Natl Mil Med Ctr, Bethesda, MD 20889 USA. [Hospenthal, Duane R.] San Antonio Mil Med Ctr, Ft Sam Houston, TX 78234 USA. RP Paolino, KM (reprint author), Walter Reed Army Inst Res, Dept Clin Trials, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. RI Paolino, Kristopher/G-1859-2012 NR 13 TC 23 Z9 23 U1 0 U2 4 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD JUN PY 2012 VL 177 IS 6 BP 681 EP 685 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA 955QP UT WOS:000305036300011 PM 22730844 ER PT J AU Roy, TC Ritland, BM Knapik, JJ Sharp, MA AF Roy, Tanja C. Ritland, Bradley M. Knapik, Joseph J. Sharp, Marilyn A. TI Lifting Tasks are Associated With Injuries During the Early Portion of a Deployment to Afghanistan SO MILITARY MEDICINE LA English DT Article ID OPERATION IRAQI FREEDOM; PHYSICAL-TRAINING PROGRAM; BRIGADE COMBAT TEAM; RISK-FACTORS; ENDURING FREEDOM; MILITARY RECRUITS; OUTPATIENT VISITS; NONBATTLE INJURY; BODY-COMPOSITION; SOLDIERS AB U.S. Army soldiers spend months at a time working in austere environments during deployments. The numerous physical demands placed on them during deployment can lead to musculoskeletal injuries. These injuries account for the majority of medical evacuations and lost duty days, seriously affecting mission readiness. Because of limited electronic injury data, little research has been done on physical demands associated with injury in deployed environments. To this end, this study conducted a survey on 263 soldiers in a Stryker Brigade Combat Team during their third month of deployment to Afghanistan. In the third month, 23% sustained an injury and 43% of injuries affected the low-back, shoulder, or knee. Dismounted patrolling and lifting were reported to account for 36% of injuries. Wearing heavy loads and lifting tasks were identified as injury risk factors. Wearing heavier equipment and lifting objects higher may increase physical demands and may result in injury. C1 [Roy, Tanja C.; Sharp, Marilyn A.] USA, Environm Med Res Inst, Natick, MA 01760 USA. [Ritland, Bradley M.] 402nd Brigade Support Battal, Stryker Brigade Combat Team 5, Infantry Div 2, Ft Lewis, WA 98433 USA. [Knapik, Joseph J.] USA, Inst Publ Hlth, Aberdeen Proving Ground, MD 21010 USA. RP Roy, TC (reprint author), USA, Environm Med Res Inst, 15 Kansas St, Natick, MA 01760 USA. FU U.S. Army Research Institute of Environmental Medicine under Task Area S FX Funding was supplied by the U.S. Army Research Institute of Environmental Medicine under Task Area S. NR 37 TC 15 Z9 15 U1 1 U2 3 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD JUN PY 2012 VL 177 IS 6 BP 716 EP 722 PG 7 WC Medicine, General & Internal SC General & Internal Medicine GA 955QP UT WOS:000305036300016 PM 22730849 ER PT J AU Staal, MA AF Staal, Mark A. TI Assessing Iraqi Arab Personality Using the Nonverbal Personality Questionnaire SO MILITARY MEDICINE LA English DT Article ID CULTURES AB The assessment of personality and related interpersonal dynamics among non-English-speaking populations offers many challenges to psychologists. Nonverbal culture-free or culture-fair instruments often fall short of adequately navigating the complex demands of non-Western cultural and ideological influences. Despite nearly a decade of America's presence within the Middle East, there remains a paucity of useful psychological assessment instruments available for use with non-English-speaking Arab populations in the region. A modified version of the Nonverbal Personality Questionnaire was used to assess personality, motivation, and interpersonal style among a small sample of Iraqi Arab male job applicants (n = 56). The various cross-cultural challenges and lessons learned from this assessment process are discussed and specific recommendations are provided. C1 US Special Operat Command, Ft Bragg, NC 28307 USA. RP Staal, MA (reprint author), US Special Operat Command, Ft Bragg, NC 28307 USA. NR 29 TC 0 Z9 0 U1 0 U2 3 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD JUN PY 2012 VL 177 IS 6 BP 732 EP 739 PG 8 WC Medicine, General & Internal SC General & Internal Medicine GA 955QP UT WOS:000305036300018 PM 22730851 ER PT J AU White, TM Elledge, JB AF White, Thomas M. Elledge, James B. TI Detainee Optometry at Camp Cropper, Iraq, 2009-2010 SO MILITARY MEDICINE LA English DT Article AB This article details the first in-depth analysis of an Optometry Service working with a large Middle Eastern detainee population composed entirely of Iraqi males. The mission of the Camp Cropper Optometry Service was to provide eye care services to the detainee population consistent with the standards of optometric care that would be provided to any U.S. military member in the same geographic area. This included providing detainees with eyeglasses, therapeutic treatment of eye disease, and referral for treatment of medical conditions and surgical care, if it was needed and available at the U.S. military facilities in the Iraq Theater. Diagnoses, services provided, and medications given to the detainees are listed in detail and demonstrate the complexity of pathology encountered in this population. C1 [White, Thomas M.] Reynolds Army Community Hosp, Optometry Serv, Ft Sill, OK 73503 USA. [Elledge, James B.] Madigan Army Med Ctr, Dept Optometry, Tacoma, WA 98431 USA. RP White, TM (reprint author), Reynolds Army Community Hosp, Optometry Serv, 4301 Wilson St, Ft Sill, OK 73503 USA. NR 8 TC 0 Z9 0 U1 0 U2 2 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD JUN PY 2012 VL 177 IS 6 BP 757 EP 762 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA 955QP UT WOS:000305036300023 PM 22730856 ER PT J AU Daraio, JA Weber, LJ Zigler, SJ Newton, TJ Nestler, JM AF Daraio, J. A. Weber, L. J. Zigler, S. J. Newton, T. J. Nestler, J. M. TI Simulated effects of host fish distribution on juvenile unionid mussel dispersal in a large river SO RIVER RESEARCH AND APPLICATIONS LA English DT Article DE ecohydraulics; host fish; spatial distribution; transport; unionids ID UPPER MISSISSIPPI RIVER; FRESH-WATER MUSSELS; ELLIPTIO-COMPLANATA MOLLUSCA; HYDRAULIC FLOW SIMULATION; CHANNEL; MOVEMENTS; PATTERNS; ABUNDANCE; STREAMS; MODEL AB Larval mussels (Family Unionidae) are obligate parasites on fish, and after excystment from their host, as juveniles, they are transported with flow. We know relatively little about the mechanisms that affect dispersal and subsequent settlement of juvenile mussels in large rivers. We used a three-dimensional hydrodynamic model of a reach of the Upper Mississippi River with stochastic Lagrangian particle tracking to simulate juvenile dispersal. Sensitivity analyses were used to determine the importance of excystment location in two-dimensional space (lateral and longitudinal) and to assess the effects of vertical location (depth in the water column) on dispersal distances and juvenile settling distributions. In our simulations, greater than 50% of juveniles mussels settled on the river bottom within 500?m of their point of excystment, regardless of the vertical location of the fish in the water column. Dispersal distances were most variable in environments with higher velocity and high gradients in velocity, such as along channel margins, near the channel bed, or where effects of river bed morphology caused large changes in hydraulics. Dispersal distance was greater and variance was greater when juvenile excystment occurred in areas where vertical velocity (w) was positive (indicating an upward velocity) than when w was negative. Juvenile dispersal distance is likely to be more variable for mussels species whose hosts inhabit areas with steeper velocity gradients (e.g. channel margins) than a host that generally inhabits low-flow environments (e.g. impounded areas). Copyright (c) 2010 John Wiley & Sons, Ltd. C1 [Daraio, J. A.; Weber, L. J.] Univ Iowa, IIHR Hydrosci & Engn, C Maxwell Stanley Hydraul Lab 100, Iowa City, IA USA. [Zigler, S. J.; Newton, T. J.] USGS, Upper Midw Environm Sci Ctr, La Crosse, WI USA. [Nestler, J. M.] USA, Engineer Res & Dev Ctr, Vicksburg, MS USA. RP Daraio, JA (reprint author), US Geol Survey, 12201 Sunrise Valley Dr,MS 436, Reston, VA 20192 USA. EM joseph.a.daraio@gmail.com OI Zigler, Steven/0000-0002-4153-0652; Daraio, Joe/0000-0001-5591-4465; Newton, Teresa/0000-0001-9351-5852 FU IIHR Hydroscience and Engineering FX This research was funded by IIHR Hydroscience and Engineering. Authors thank George Constantinescu, Keri Hornbuckle, Lee Hastie, David Strayer, Mike Gangloff and two anonymous reviewers for comments on earlier drafts of the manuscript. Product names are provided for informational purposes only and do not represent an endorsement by the US Geological Survey. NR 60 TC 6 Z9 6 U1 1 U2 29 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1535-1459 J9 RIVER RES APPL JI River Res. Appl. PD JUN PY 2012 VL 28 IS 5 BP 594 EP 608 DI 10.1002/rra.1469 PG 15 WC Environmental Sciences; Water Resources SC Environmental Sciences & Ecology; Water Resources GA 951YT UT WOS:000304757400007 ER PT J AU Ingram, K Ellis, W Keiser, J AF Ingram, Katrin Ellis, William Keiser, Jennifer TI Antischistosomal Activities of Mefloquine-Related Aryhnethanols SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY LA English DT Article ID ANTI-MALARIAL ACTIVITIES; SCHISTOSOMA-MANSONI; IN-VITRO; PLASMODIUM-FALCIPARUM; ANTIMALARIAL ACTIVITY; QUINOLINE METHANOLS; SPECIAL ATTENTION; PRAZIQUANTEL; VIVO; HAEMATOBIUM AB Interesting antischistosomal properties have been documented for the antimalarial mefloquine, a 4-quinolinemethanol. We evaluated the antischistosomal activities of nine mefloquine-related compounds belonging to the 4-pyridinemethanols, 9-phenanthrenmethanols, and 4-quinolinemethanols. Eight compounds revealed high activities against Schistosoma mansoni in vitro, with two drugs (the 4-quinolinemethanols WR7573 and WR7930) characterized by significantly lower half-maximal inhibitory concentrations (IC(50)s) (2.7 and 3.5 mu M, respectively) compared to mefloquine (11.4 mu M). Mefloquine and WR7930 showed significantly decreased IC(50)s when incubated in the presence of hemoglobin. High worm burden reductions (WBR) were obtained with enpiroline (WBR, 82.7%; dosage, 200 mg/kg of body weight) and its threo isomers (+)-threo (WBR, 100%) and (-)threo (WBR, 89%) and with WR7930 (WBR, 87%; dosage, 100 mg/kg) against adult S. mansoni in mice. Furthermore, excellent in vitro and in vivo antischistosomal activity was observed for two WR7930-related structures (WR29252 and WR7524). In addition, mefloquine (WBR, 81%), enpiroline (WBR, 77%), and WR7930 (WBR, 100%) showed high activities against S. haematobium harbored in mice following single oral doses of 200 mg/kg. These results provide a deeper insight into the structural features of the arylmethanols that rule antischistosomal activity. Further studies should be launched with enpiroline and WR7930. C1 [Ingram, Katrin; Keiser, Jennifer] Swiss Trop & Publ Hlth Inst, Dept Med Parasitol & Infect Biol, Basel, Switzerland. [Ingram, Katrin; Keiser, Jennifer] Univ Basel, Basel, Switzerland. [Ellis, William] Walter Reed Army Med Ctr, Walter Reed Army Inst Res, Dept Chem Informat, Washington, DC 20307 USA. RP Keiser, J (reprint author), Swiss Trop & Publ Hlth Inst, Dept Med Parasitol & Infect Biol, Basel, Switzerland. EM jennifer.keiser@unibas.ch FU Swiss National Science Foundation [PPOOA-114941, PPOOP3_135170] FX J. Keiser is grateful to the Swiss National Science Foundation for financial support (grants PPOOA-114941 and PPOOP3_135170). NR 37 TC 28 Z9 28 U1 0 U2 3 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0066-4804 J9 ANTIMICROB AGENTS CH JI Antimicrob. Agents Chemother. PD JUN PY 2012 VL 56 IS 6 BP 3207 EP 3215 DI 10.1128/AAC.06177-11 PG 9 WC Microbiology; Pharmacology & Pharmacy SC Microbiology; Pharmacology & Pharmacy GA 947LZ UT WOS:000304432800055 PM 22470113 ER PT J AU Emmons, ED Farrell, ME Holthoff, EL Tripathi, A Green, N Moon, RP Guicheteau, JA Christesen, SD Pellegrino, PM Fountain, AW AF Emmons, Erik D. Farrell, Mikella E. Holthoff, Ellen L. Tripathi, Ashish Green, Norman Moon, Raphael P. Guicheteau, Jason A. Christesen, Steven D. Pellegrino, Paul M. Fountain, Augustus W., III TI Characterization of Polymorphic States in Energetic Samples of 1,3,5-Trinitro-1,3,5-Triazine (RDX) Fabricated Using Drop-on-Demand Inkjet Technology SO APPLIED SPECTROSCOPY LA English DT Article DE Inkjet printing; Drop-on-demand; Polymorphic phases; RDX; Raman ID SURFACE-ENHANCED RAMAN; TRACE EXPLOSIVES; IDENTIFICATION; SPECTROSCOPY; SCATTERING; SPECTRA; AGENTS AB The United States Army and the first responder community are evaluating optical detection systems for the trace detection of hazardous energetic materials. Fielded detection systems must he evaluated with the appropriate material concentrations to accurately identify the residue in theater. Trace levels of energetic materials have been observed in mutable polymorphic phases and, therefore, the systems being evaluated must be able to detect and accurately identify variant sample phases observed in spectral data. In this work, we report on the novel application of drop-on-demand technology for the fabrication of standardized trace 1,3,5-trinitro-1,3,5-triazine (RDX) samples. The drop-on-demand sample fabrication technique is compared both visually and spectrally to the more commonly used drop-and-dry technique. As the drop-on-demand technique allows for the fabrication of trace level hazard materials, concerted efforts focused on characterization of the polymorphic phase changes observed with low concentrations of RDX commonly used in drop-on-demand processing. This information is important when evaluating optical detection technologies using samples prepared with a drop-on-demand inkjet system, as the technology may be "trained" to detect the common bulk alpha phase of the explosive based on its spectral features hut fall short in positively detecting a trace quantity of RDX (beta-phase). We report the polymorphic shifts observed between alpha- and beta-phases of this energetic material and discuss the conditions leading to the favoring of one phase over the other. C1 [Farrell, Mikella E.; Holthoff, Ellen L.; Pellegrino, Paul M.] USA, Res Lab, RDRL SEE E, Adelphi, MD 20783 USA. [Emmons, Erik D.; Tripathi, Ashish] Sci Applicat Int Corp, Gunpowder Branch, Aberdeen Proving Ground, MD 21010 USA. [Green, Norman] Sci & Technol Corp, Edgewood, MD 21040 USA. [Moon, Raphael P.; Guicheteau, Jason A.; Christesen, Steven D.; Fountain, Augustus W., III] USA, Edgewood Chem Biol Ctr, RDCB DRD L, Aberdeen Proving Ground, MD 21010 USA. RP Holthoff, EL (reprint author), USA, Res Lab, RDRL SEE E, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM ellen.l.holthoff.civ@mail.mil; steven.d.christesen.civ@mail.mil RI Hankus, Mikella/A-9005-2012 NR 35 TC 13 Z9 13 U1 3 U2 33 PU SOC APPLIED SPECTROSCOPY PI FREDERICK PA 5320 SPECTRUM DRIVE SUITE C, FREDERICK, MD 21703 USA SN 0003-7028 J9 APPL SPECTROSC JI Appl. Spectrosc. PD JUN PY 2012 VL 66 IS 6 BP 628 EP 635 DI 10.1366/12-06608 PG 8 WC Instruments & Instrumentation; Spectroscopy SC Instruments & Instrumentation; Spectroscopy GA 948MN UT WOS:000304507400002 PM 22732532 ER PT J AU Estrada, A Kelley, AM Webb, CM Athy, JR Crowley, JS AF Estrada, Arthur Kelley, Amanda M. Webb, Catherine M. Athy, Jeremy R. Crowley, John S. TI Modafinil as a Replacement for Dextroamphetamine for Sustaining Alertness in Military Helicopter Pilots SO AVIATION SPACE AND ENVIRONMENTAL MEDICINE LA English DT Article DE modafinil; dextroamphetamine; stimulants; extended wakefulness; sustained helicopter operations; fatigue ID SLEEP-DEPRIVATION; COGNITIVE PERFORMANCE; D-AMPHETAMINE; SHIFT WORK; CAFFEINE; FATIGUE; MOOD; WAKEFULNESS; SIMULATOR; TEMPERATURE AB Introduction: Successful military aviation operations depend on maintaining continuous day-night operations. Stimulants are easy to use and popular for sustaining performance because their utility is not dependent upon environmental or scheduling modifications. Dextroamphetamine is authorized for use by the aircrews of all U.S. military services, but its potential for abuse and subsequent addiction is of aeromedical concern. Finding an alternative stimulant, such as modafinil, that displays a low affinity for dopamine uptake binding sites would prove extremely beneficial. This study sought to establish the efficacy and safety of modafinil during actual flying operations, thus providing the operational validity desired to approve the use of modafinil for helicopter flight operations. Methods: During two, 40-h periods of sustained wakefulness, 18 helicopter pilots (17 men, 1 woman, mean years of age = 29.5) each completed 15 flights and other evaluations, during which they received 2 of 3 experimental conditions: 3 closes at 4-h intervals of modafinil (100 mg), dextroamphetamine (5 mg), or placebo. Results: Statistical results showed that modafinil, like dextroamphetamine, maintained alertness, feelings of well-being, cognitive function, judgment, risk perception, and situation awareness of sleep-deprived aviators consistently better than placebo and without side effects of aeromedical concern. Discussion: Like previous research, this study strongly suggests that both drugs can maintain acceptable levels of mood and performance during sleep deprivation. The results also confirm that modafinil is well tolerated and appears to be a good alternative to dextroamphetamine for countering the debilitating mood and cognitive effects of sleep loss during sustained operations. C1 [Estrada, Arthur; Kelley, Amanda M.; Webb, Catherine M.; Athy, Jeremy R.; Crowley, John S.] USA, Warfighter Hlth Div, Aeromed Res Lab, Ft Rucker, AL 36362 USA. RP Estrada, A (reprint author), USA, Warfighter Hlth Div, Aeromed Res Lab, 6901 Ferrel Rd,POB 620577, Ft Rucker, AL 36362 USA. EM arthur.estrada@us.army.mil FU U.S. Special Operations Command Biomedical Initiative Steering Committee; U.S. Army Medical Research and Materiel Command's Military Operational Medicine Research Program FX The authors would like to acknowledge the dedication and professionalism of the research pilots of the Flight Systems Branch and the research staff of the Warfighter Health Division, U.S. Army Aeromedical Research Laboratory, for their contributions to the success of this project. This study was funded by the U.S. Special Operations Command Biomedical Initiative Steering Committee and the U.S. Army Medical Research and Materiel Command's Military Operational Medicine Research Program. NR 38 TC 10 Z9 11 U1 1 U2 21 PU AEROSPACE MEDICAL ASSOC PI ALEXANDRIA PA 320 S HENRY ST, ALEXANDRIA, VA 22314-3579 USA SN 0095-6562 J9 AVIAT SPACE ENVIR MD JI Aviat. Space Environ. Med. PD JUN PY 2012 VL 83 IS 6 BP 556 EP 564 DI 10.3357/ASEM.3129.2012 PG 9 WC Public, Environmental & Occupational Health; Medicine, General & Internal; Sport Sciences SC Public, Environmental & Occupational Health; General & Internal Medicine; Sport Sciences GA 951MB UT WOS:000304723600002 PM 22764609 ER PT J AU Convertino, VA AF Convertino, Victor A. TI Blood Pressure Measurement for Accurate Assessment of Patient Status in Emergency Medical Settings SO AVIATION SPACE AND ENVIRONMENTAL MEDICINE LA English DT Article DE medical monitoring; shock monitor; central hypovolemia; lower body negative pressure ID CENTRAL HYPOVOLEMIA; FINGER; HEMORRHAGE; HUMANS; SHOCK AB Obtaining blood pressure measurements with traditional sphygomanometry that are insensitive and nonspecific can fail to provide an accurate assessment of patient status, particularly in specific clinical scenarios of acute reduction in central blood volume such as hemorrhage or orthostatic testing. This paper provides a review of newly emerging monitoring technologies that are being developed and integrated to improve patient diagnosis by using collection and feature extraction in real time of arterial waveforms by machine-learning algorithms. With assessment of continuous, noninvasively measured arterial waveforms, machine-learning algorithms have been developed with the capability to predict cardiovascular collapse with >96% accuracy and a correlation of 0.89 between the time of predicted and actual cardiovascular collapse (e.g., shock, syncope) using a human model of progressive central hypovolemia. The resulting capability to obtain earlier predictions of imminent hemodynamic instability has significant implications for effective countermeasure applications by the aeromedical community. The ability to obtain real-time, continuous information about changes in features and patterns of arterial waveforms in addition to standard blood pressure provides for the first time the capability to assess the status of circulatory blood volume of the patient and can be used to diagnose progression toward development of syncope or overt shock, or guide fluid resuscitation. C1 USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Convertino, VA (reprint author), USA, Inst Surg Res, 3698 Chambers Pass, Ft Sam Houston, TX 78234 USA. EM victor.convertino@amedd.army.mil FU United States Army Medical Research and Materiel Command Combat Casualty Care Research Program FX The author thanks his numerous collaborators at the U.S. Army Institute of Surgical Research, University of Colorado, and Flashback Technologies, LLC, for their efforts in the collection and analysis of data, and the experimental subjects for their cooperation. This research was supported by funding from the United States Army Medical Research and Materiel Command Combat Casualty Care Research Program. NR 22 TC 10 Z9 10 U1 0 U2 11 PU AEROSPACE MEDICAL ASSOC PI ALEXANDRIA PA 320 S HENRY ST, ALEXANDRIA, VA 22314-3579 USA SN 0095-6562 J9 AVIAT SPACE ENVIR MD JI Aviat. Space Environ. Med. PD JUN PY 2012 VL 83 IS 6 BP 614 EP 619 DI 10.3357/ASEM.3204.2012 PG 6 WC Public, Environmental & Occupational Health; Medicine, General & Internal; Sport Sciences SC Public, Environmental & Occupational Health; General & Internal Medicine; Sport Sciences GA 951MB UT WOS:000304723600011 PM 22764618 ER PT J AU Benson, MJ Elkins, CJ Yapa, SD Ling, JB Eaton, JK AF Benson, Michael J. Elkins, Christopher J. Yapa, Sayuri D. Ling, Julia B. Eaton, John K. TI Effects of varying Reynolds number, blowing ratio, and internal geometry on trailing edge cutback film cooling SO EXPERIMENTS IN FLUIDS LA English DT Article ID GAS-TURBINE AIRFOILS AB Three-dimensional mean velocity and concentration fields have been measured for a water flow in a pressure side cutback trailing edge film cooling geometry consisting of rectangular film cooling slots separated by tapered lands. Three-component mean velocities were measured with conventional magnetic resonance velocimetry, while time-averaged concentration distributions were measured with a magnetic resonance concentration technique for flow at two Reynolds numbers (Re) differing by a factor of 2, three blowing ratios, and with and without an internal pin fin array in the coolant feed channel. The results show that the flows are essentially independent of Re for the regime tested in terms of the film cooling surface effectiveness, normalized velocity profiles, and normalized mean streamwise vorticity. Blowing ratio changes had a larger effect, with higher blowing ratios resulting in surface effectiveness improvements at downstream locations. The addition of a pin fin array within the slot feed channel made the spanwise distribution of coolant at the surface more uniform. Results are compared with transonic experiments in air at realistic density ratios described by Holloway et al. (2002a). C1 [Benson, Michael J.] US Mil Acad, Dept Civil & Mech Engn, West Point, NY 10996 USA. [Elkins, Christopher J.; Yapa, Sayuri D.; Ling, Julia B.; Eaton, John K.] Stanford Univ, Dept Mech Engn, Stanford, CA 94305 USA. RP Benson, MJ (reprint author), US Mil Acad, Dept Civil & Mech Engn, West Point, NY 10996 USA. EM michael.benson@usma.edu FU General Electric under the University Strategic Alliance; U. S. Army Research Office [57392-EG-II]; United States Army FX Financial support for the project was provided by General Electric under the University Strategic Alliance program. In addition, this material is based upon work supported in part by the U. S. Army Research Office under contract/grant number 57392-EG-II. Use of the facilities at the Richard M. Lucas Center for Magnetic Resonance Spectroscopy and Imaging is gratefully acknowledged. The authors wish to thank the United States Army for funding the first author in his doctoral studies at Stanford. The views expressed herein are those of the authors and do not purport to reflect the position of the Department of the Army, or the Department of Defense. NR 16 TC 9 Z9 9 U1 0 U2 10 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0723-4864 J9 EXP FLUIDS JI Exp. Fluids PD JUN PY 2012 VL 52 IS 6 BP 1415 EP 1430 DI 10.1007/s00348-012-1260-1 PG 16 WC Engineering, Mechanical; Mechanics SC Engineering; Mechanics GA 950CB UT WOS:000304625600005 ER PT J AU Crane, CC AF Crane, Conrad C. TI No Sure Victory: Measuring US Army Effectiveness and Progress in the Vietnam War SO JOURNAL OF AMERICAN HISTORY LA English DT Book Review C1 [Crane, Conrad C.] USA, War Coll, Carlisle, PA 17013 USA. RP Crane, CC (reprint author), USA, War Coll, Carlisle, PA 17013 USA. NR 1 TC 0 Z9 0 U1 0 U2 3 PU ORGANIZATION AMER HISTORIANS PI BLOOMINGTON PA 112 N BRYAN ST, BLOOMINGTON, IN 47408 USA SN 0021-8723 J9 J AM HIST JI J. Am. Hist. PD JUN PY 2012 VL 99 IS 1 SI SI BP 365 EP 365 DI 10.1093/jahist/jas068 PG 1 WC History SC History GA 948YB UT WOS:000304538800123 ER PT J AU Arcone, SA Boitnott, GE AF Arcone, Steven A. Boitnott, Ginger E. TI Maxwell-Wagner relaxation in common minerals and a desert soil at low water contents SO JOURNAL OF APPLIED GEOPHYSICS LA English DT Article DE Maxwell-Wagner; Ground-penetrating radar; Complex permittivity; Attenuation rate; Dispersion ID DIELECTRIC PERMITTIVITY; INDUCED POLARIZATION; DISPERSION; SANDSTONES; DOMAIN; CLAYS; LAYER AB Penetration of 100- to 1000-MHz ground-penetrating radar (GPR) signals is virtually non-existent in arid and desert soils despite their low water content and moderate conductivity, the latter of which cannot explain the loss. Under the hypothesis that strong dielectric relaxation supplements DC conductivity to cause high intrinsic attenuation rates, we compared the complex permittivity of a desert soil sample with that of controlled samples of quartz, feldspars, calcite, coarse and crystallite gypsum, kaolinite and montmorillonite. The soil had 80% quartz, 10% feldspars and 10% gypsum by weight, with the latter composed of crystallites and crustations. All samples had 4-7% volumetric water content. We measured permittivity most accurately from 1.6 MHz to 4 GHz with Fourier Transform time domain reflectometry, and used grain sizes less than 53 urn. All samples show low-frequency dispersion with the soil, gypsum crystallites and montmorillonite having the strongest below 100 MHz, the highest attenuation rates, and conductivity values unable to account for these rates. The soil rate exceeded 100 dB m(-1) by 1 GHz. Through modeling we find that a broadened relaxation centered from 2 to 16 MHz sufficiently supplements losses caused by conductivity and free water relaxation to account for loss rates in all our samples, and accounts for low-frequency dispersion below 1 GHz. We interpret the relaxation to be of the Maxwell-Wagner (MW) type because of the 2- to 16-MHz values, relaxation broadening, the lack of salt, clay and magnetic minerals, and insufficient surface area to support adsorbed water. The likely MW dipolar soil inclusions within the predominantly quartz matrix were gypsum particles coated with water containing ions dissolved from the gypsum, and the conducting water layers themselves. The inclusions for the monomineralic soils were likely ionized partially or completely water-filled interstices, and partially filled galleries for the montmorillonite. The low water content may be necessary to help isolate these inclusions. For our common, low conductivity minerals, the MW contributions to attenuation rates are significant above 10 MHz, whereas they are significant above about 100 MHz for the more conductive minerals and soil. Published by Elsevier B.V. C1 [Arcone, Steven A.; Boitnott, Ginger E.] USA, Cold Reg Res & Engn Lab, ERDC, Hanover, NH 03755 USA. RP Arcone, SA (reprint author), USA, Cold Reg Res & Engn Lab, ERDC, 72 Lyme Rd, Hanover, NH 03755 USA. EM Steven.A.Arcone@usace.army.mil; Ginger.E.Boitnott@usace.army.mil FU U.S. Army Engineering and Research Development Center FX We thank Technology of Materials Corp., Wildomar, CA, for XRD and Susan Taylor of CRREL for SEM/EDXRD analysis and comments, and Particle Technology Labs, Ltd., Downers Grove, IL for particle analyses. This work was supported by the U.S. Army Engineering and Research Development Center 6.1 program in basic research. Permission to publish was granted by Director, Cold Regions Research and Engineering Laboratory. NR 36 TC 7 Z9 7 U1 1 U2 3 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0926-9851 J9 J APPL GEOPHYS JI J. Appl. Geophys. PD JUN PY 2012 VL 81 SI SI BP 97 EP 105 DI 10.1016/j.jappgeo.2011.09.005 PG 9 WC Geosciences, Multidisciplinary; Mining & Mineral Processing SC Geology; Mining & Mineral Processing GA 949LY UT WOS:000304578900012 ER PT J AU Arcone, S Liu, LB AF Arcone, Steven Liu, Lanbo TI Spatial attenuation rates of interfacial waves: Field and numerical tests of Sommerfeld theory using ground-penetrating radar pulses SO JOURNAL OF APPLIED GEOPHYSICS LA English DT Article DE Surface waves; Interfacial waves; Sommerfeld; Dielectric ground; Attenuation rates; GPR ID UPPER-ATMOSPHERE; SURFACE-WAVE; RADIO-WAVES; PROPAGATION; EARTH AB We tested the geometric amplitude attenuation rates predicted by classic Sommerfeld theory for horizontally polarized interfacial waves propagating over dielectric ground. We used ground-penetrating radar pulses, the brief time duration of which allowed different interfacial wave modes to separate. We tested rates in the intermediate range of tens of wavelengths, and for azimuthal and radial polarizations. For azimuthal polarization, a closed form solution predicts inverse range-squared rates, and for radial polarization, calculations suggest an inverse range exponent between 1 and 2. Over low loss frozen ground having a dielectric constant of 6.8 azimuthally polarized air waves centered at 46 MHz attenuated nearly in proportion to the square of range, as predicted, while the radial rate at 37 MHz was close to the 1.6 power of range, as generally expected. At 360-390 MHz, air wave rates were higher than expected and likely caused by scattering losses. Three D time domain modeling at 37 MHz confirmed the rate for azimuthal polarization and the qualitative difference in rates between the two polarizations, but the exponent may be about 26% too high for the radial case. Not readily extractable from Sommerfeld theory are rates for subsurface direct waves, for which our models show that both polarizations attenuate in proportion to the square of range after about 5 subsurface wavelengths. This suggests that geometric rates for all horizontally polarized subsurface interfacial waves spatially attenuate in proportion to range-squared in both intermediate and far field ranges, and so could be subtracted from actual rates to determine loss rates caused by intrinsic attenuation and scattering. (C) 2011 Published by Elsevier B.V. C1 [Arcone, Steven] USA, Cold Reg Res & Engn Lab, ERDC, Hanover, NH 03755 USA. [Liu, Lanbo] Univ Connecticut, Dept Civil & Environm Engn, Storrs, CT USA. RP Arcone, S (reprint author), USA, Cold Reg Res & Engn Lab, ERDC, 72 Lyme Rd, Hanover, NH 03755 USA. EM Steven.A.Arcone@usace.army.mil; Lanbo.Liu@uconn.edu FU U.S. Army Engineering and Research Development Center FX The authors thank Mr. Allan Delaney, formerly of CRREL, for his field assistance, and Dr. Peter Annan and Dr. Klaus Holliger for their insightful reviews. This work was supported by the U.S. Army Engineering and Research Development Center 6.1 program in basic research. Permission to publish was granted by Director, Cold Regions Research and Engineering Laboratory. NR 24 TC 2 Z9 2 U1 2 U2 7 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0926-9851 J9 J APPL GEOPHYS JI J. Appl. Geophys. PD JUN PY 2012 VL 81 SI SI BP 122 EP 129 DI 10.1016/j.jappgeo.2011.11.007 PG 8 WC Geosciences, Multidisciplinary; Mining & Mineral Processing SC Geology; Mining & Mineral Processing GA 949LY UT WOS:000304578900015 ER PT J AU Jenkins, AL Ellzy, MW Buettner, LC AF Jenkins, Amanda L. Ellzy, Michael W. Buettner, Leonard C. TI Molecularly imprinted polymer sensors for detection in the gas, liquid, and vapor phase SO JOURNAL OF MOLECULAR RECOGNITION LA English DT Article DE molecularly imprinted polymers; denuder; sensors; europium; chemical agents; detection; SPME ID WATER; MICROEXTRACTION; PESTICIDES AB Fast, reliable, and inexpensive analytical techniques for detection of airborne chemical warfare agents are desperately needed. Recent advances in the field of molecularly imprinted polymers have created synthetic nanomaterials that can sensitively and selectively detect these materials in aqueous environments, but thus far, they have not been demonstrated to work for detection of vapors. The imprinted polymers function by mimicking the function of biological receptors. They can provide high sensitivity and selectivity but, unlike their biological counterparts, maintain excellent thermal and mechanical stability. The traditional imprinted polymer approach is further enhanced in this work by the addition of a luminescent europium that has been introduced into the polymers to provide enhanced chemical affinity as well as a method for signal transduction to indicate the binding event. The europium in these polymers is so sensitive to the bound target; it can distinguish between species differing by a single methyl group. The imprinted polymer technology is fiber optic-based making it inexpensive and easily integratable with commercially available miniature fiber optic spectrometer technologies to provide a shoebox size device. In this work, we will describe efforts to apply these sensors for detection of airborne materials and vapors. Successful application of this technology will provide accurate low level vapor detection of chemical agents or pesticides with little to no false positives. Published 2012. This article is a U.S. Government work and is in the public domain in the USA. C1 [Jenkins, Amanda L.] ASK Inc, Hebron, MD 21830 USA. [Ellzy, Michael W.; Buettner, Leonard C.] USA, RDECOM, Aberdeen Proving Ground, MD 21010 USA. RP Jenkins, AL (reprint author), ASK Inc, 7447 Rockawalkin Rd, Hebron, MD 21830 USA. EM amanda21801@yahoo.com FU Edgewood Chemical and Biological Center FX The authors of this paper would like to thank the Edgewood Chemical and Biological Center for financial support. NR 21 TC 5 Z9 5 U1 2 U2 28 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0952-3499 J9 J MOL RECOGNIT JI J. Mol. Recognit. PD JUN PY 2012 VL 25 IS 6 SI SI BP 330 EP 335 DI 10.1002/jmr.2169 PG 6 WC Biochemistry & Molecular Biology; Biophysics SC Biochemistry & Molecular Biology; Biophysics GA 947XW UT WOS:000304468900005 PM 22641530 ER PT J AU Jacobs, KB Yeager, M Zhou, WY Wacholder, S Wang, ZM Rodriguez-Santiago, B Hutchinson, A Deng, X Liu, CW Horner, MJ Cullen, M Epstein, CG Burdett, L Dean, MC Chatterjee, N Sampson, J Chung, CC Kovaks, J Gapstur, SM Stevens, VL Teras, LT Gaudet, MM Albanes, D Weinstein, SJ Virtamo, J Taylor, PR Freedman, ND Abnet, CC Goldstein, AM Hu, N Yu, K Yuan, JM Liao, LD Ding, T Qiao, YL Gao, YT Koh, WP Xiang, YB Tang, ZZ Fan, JH Aldrich, MC Amos, C Blot, WJ Bock, CH Gillanders, EM Harris, CC Haiman, CA Henderson, BE Kolonel, LN Le Marchand, L McNeill, LH Rybicki, BA Schwartz, AG Signorello, LB Spitz, MR Wiencke, JK Wrensch, M Wu, XF Zanetti, KA Ziegler, RG Figueroa, JD Garcia-Closas, M Malats, N Marenne, G Prokunina-Olsson, L Baris, D Schwenn, M Johnson, A Landi, MT Goldin, L Consonni, D Bertazzi, PA Rotunno, M Rajaraman, P Andersson, U Freeman, LEB Berg, CD Buring, JE Butler, MA Carreon, T Feychting, M Ahlbom, A Gaziano, JM Giles, GG Hallmans, G Hankinson, SE Hartge, P Henriksson, R Inskip, PD Johansen, C Landgren, A McKean-Cowdin, R Michaud, DS Melin, BS Peters, U Ruder, AM Sesso, HD Severi, G Shu, XO Visvanathan, K White, E Wolk, A Zeleniuch-Jacquotte, A Zheng, W Silverman, DT Kogevinas, M Gonzalez, JR Villa, O Li, DH Duell, EJ Risch, HA Olson, SH Kooperberg, C Wolpin, BM Jiao, L Hassan, M Wheeler, W Arslan, AA Bueno-de-Mesquita, HB Fuchs, CS Gallinger, S Gross, MD Holly, EA Klein, AP LaCroix, A Mandelson, MT Petersen, G Boutron-Ruault, MC Bracci, PM Canzian, F Chang, K Cotterchio, M Giovannucci, EL Goggins, M Bolton, JAH Jenab, M Khaw, KT Krogh, V Kurtz, RC McWilliams, RR Mendelsohn, JB Rabe, KG Riboli, E Tjonneland, A Tobias, GS Trichopoulos, D Elena, JW Yu, H Amundadottir, L Stolzenberg-Solomon, RZ Kraft, P Schumacher, F Stram, D Savage, SA Mirabello, L Andrulis, IL Wunder, JS Garcia, AP Sierrasesumaga, L Barkauskas, DA Gorlick, RG Purdue, M Chow, WH Moore, LE Schwartz, KL Davis, FG Hsing, AW Berndt, SI Black, A Wentzensen, N Brinton, LA Lissowska, J Peplonska, B McGlynn, KA Cook, MB Graubard, BI Kratz, CP Greene, MH Erickson, RL Hunter, DJ Thomas, G Hoover, RN Real, FX Fraumeni, JF Caporaso, NE Tucker, M Rothman, N Perez-Jurado, LA Chanock, SJ AF Jacobs, Kevin B. Yeager, Meredith Zhou, Weiyin Wacholder, Sholom Wang, Zhaoming Rodriguez-Santiago, Benjamin Hutchinson, Amy Deng, Xiang Liu, Chenwei Horner, Marie-Josephe Cullen, Michael Epstein, Caroline G. Burdett, Laurie Dean, Michael C. Chatterjee, Nilanjan Sampson, Joshua Chung, Charles C. Kovaks, Joseph Gapstur, Susan M. Stevens, Victoria L. Teras, Lauren T. Gaudet, Mia M. Albanes, Demetrius Weinstein, Stephanie J. Virtamo, Jarmo Taylor, Philip R. Freedman, Neal D. Abnet, Christian C. Goldstein, Alisa M. Hu, Nan Yu, Kai Yuan, Jian-Min Liao, Linda Ding, Ti Qiao, You-Lin Gao, Yu-Tang Koh, Woon-Puay Xiang, Yong-Bing Tang, Ze-Zhong Fan, Jin-Hu Aldrich, Melinda C. Amos, Christopher Blot, William J. Bock, Cathryn H. Gillanders, Elizabeth M. Harris, Curtis C. Haiman, Christopher A. Henderson, Brian E. Kolonel, Laurence N. Le Marchand, Loic McNeill, Lorna H. Rybicki, Benjamin A. Schwartz, Ann G. Signorello, Lisa B. Spitz, Margaret R. Wiencke, John K. Wrensch, Margaret Wu, Xifeng Zanetti, Krista A. Ziegler, Regina G. Figueroa, Jonine D. Garcia-Closas, Montserrat Malats, Nuria Marenne, Gaelle Prokunina-Olsson, Ludmila Baris, Dalsu Schwenn, Molly Johnson, Alison Landi, Maria Teresa Goldin, Lynn Consonni, Dario Bertazzi, Pier Alberto Rotunno, Melissa Rajaraman, Preetha Andersson, Ulrika Freeman, Laura E. Beane Berg, Christine D. Buring, Julie E. Butler, Mary A. Carreon, Tania Feychting, Maria Ahlbom, Anders Gaziano, J. Michael Giles, Graham G. Hallmans, Goran Hankinson, Susan E. Hartge, Patricia Henriksson, Roger Inskip, Peter D. Johansen, Christoffer Landgren, Annelie McKean-Cowdin, Roberta Michaud, Dominique S. Melin, Beatrice S. Peters, Ulrike Ruder, Avima M. Sesso, Howard D. Severi, Gianluca Shu, Xiao-Ou Visvanathan, Kala White, Emily Wolk, Alicja Zeleniuch-Jacquotte, Anne Zheng, Wei Silverman, Debra T. Kogevinas, Manolis Gonzalez, Juan R. Villa, Olaya Li, Donghui Duell, Eric J. Risch, Harvey A. Olson, Sara H. Kooperberg, Charles Wolpin, Brian M. Jiao, Li Hassan, Manal Wheeler, William Arslan, Alan A. Bueno-de-Mesquita, H. Bas Fuchs, Charles S. Gallinger, Steven Gross, Myron D. Holly, Elizabeth A. Klein, Alison P. LaCroix, Andrea Mandelson, Margaret T. Petersen, Gloria Boutron-Ruault, Marie-Christine Bracci, Paige M. Canzian, Federico Chang, Kenneth Cotterchio, Michelle Giovannucci, Edward L. Goggins, Michael Bolton, Judith A. Hoffman Jenab, Mazda Khaw, Kay-Tee Krogh, Vittorio Kurtz, Robert C. McWilliams, Robert R. Mendelsohn, Julie B. Rabe, Kari G. Riboli, Elio Tjonneland, Anne Tobias, Geoffrey S. Trichopoulos, Dimitrios Elena, Joanne W. Yu, Herbert Amundadottir, Laufey Stolzenberg-Solomon, Rachael Z. Kraft, Peter Schumacher, Fredrick Stram, Daniel Savage, Sharon A. Mirabello, Lisa Andrulis, Irene L. Wunder, Jay S. Patino Garcia, Ana Sierrasesumaga, Luis Barkauskas, Donald A. Gorlick, Richard G. Purdue, Mark Chow, Wong-Ho Moore, Lee E. Schwartz, Kendra L. Davis, Faith G. Hsing, Ann W. Berndt, Sonja I. Black, Amanda Wentzensen, Nicolas Brinton, Louise A. Lissowska, Jolanta Peplonska, Beata McGlynn, Katherine A. Cook, Michael B. Graubard, Barry I. Kratz, Christian P. Greene, Mark H. Erickson, Ralph L. Hunter, David J. Thomas, Gilles Hoover, Robert N. Real, Francisco X. Fraumeni, Joseph F., Jr. Caporaso, Neil E. Tucker, Margaret Rothman, Nathaniel Perez-Jurado, Luis A. Chanock, Stephen J. TI Detectable clonal mosaicism and its relationship to aging and cancer SO NATURE GENETICS LA English DT Article ID CHRONIC LYMPHOCYTIC-LEUKEMIA; GENOMIC IMBALANCES; MAFFUCCI SYNDROME; OLLIER DISEASE; MUTATIONS; SUSCEPTIBILITY; ASSOCIATION; ABERRATIONS; MECHANISMS; ANEUPLOIDY AB In an analysis of 31,717 cancer cases and 26,136 cancer-free controls from 13 genome-wide association studies, we observed large chromosomal abnormalities in a subset of clones in DNA obtained from blood or buccal samples. We observed mosaic abnormalities, either aneuploidy or copy-neutral loss of heterozygosity, of > 2 Mb in size in autosomes of 517 individuals (0.89%), with abnormal cell proportions of between 7% and 95%. In cancer-free individuals, frequency increased with age, from 0.23% under 50 years to 1.91% between 75 and 79 years (P = 4.8 x 10(-8)). Mosaic abnormalities were more frequent in individuals with solid tumors (0.97% versus 0.74% in cancer-free individuals; odds ratio (OR) = 1.25; P = 0.016), with stronger association with cases who had DNA collected before diagnosis or treatment (OR = 1.45; P = 0.0005). Detectable mosaicism was also more common in individuals for whom DNA was collected at least 1 year before diagnosis with leukemia compared to cancer-free individuals (OR = 35.4; P = 3.8 x 10(-11)). These findings underscore the time-dependent nature of somatic events in the etiology of cancer and potentially other late-onset diseases. C1 [Jacobs, Kevin B.; Yeager, Meredith; Zhou, Weiyin; Wacholder, Sholom; Wang, Zhaoming; Hutchinson, Amy; Deng, Xiang; Liu, Chenwei; Horner, Marie-Josephe; Cullen, Michael; Epstein, Caroline G.; Burdett, Laurie; Chatterjee, Nilanjan; Sampson, Joshua; Chung, Charles C.; Kovaks, Joseph; Albanes, Demetrius; Weinstein, Stephanie J.; Taylor, Philip R.; Freedman, Neal D.; Abnet, Christian C.; Goldstein, Alisa M.; Hu, Nan; Yu, Kai; Liao, Linda; Ziegler, Regina G.; Figueroa, Jonine D.; Garcia-Closas, Montserrat; Prokunina-Olsson, Ludmila; Baris, Dalsu; Landi, Maria Teresa; Goldin, Lynn; Rotunno, Melissa; Rajaraman, Preetha; Freeman, Laura E. Beane; Hartge, Patricia; Inskip, Peter D.; Landgren, Annelie; Silverman, Debra T.; Mendelsohn, Julie B.; Tobias, Geoffrey S.; Amundadottir, Laufey; Stolzenberg-Solomon, Rachael Z.; Savage, Sharon A.; Mirabello, Lisa; Purdue, Mark; Chow, Wong-Ho; Moore, Lee E.; Hsing, Ann W.; Berndt, Sonja I.; Black, Amanda; Wentzensen, Nicolas; Brinton, Louise A.; McGlynn, Katherine A.; Cook, Michael B.; Graubard, Barry I.; Kratz, Christian P.; Greene, Mark H.; Hoover, Robert N.; Fraumeni, Joseph F., Jr.; Caporaso, Neil E.; Tucker, Margaret; Rothman, Nathaniel; Chanock, Stephen J.] NCI, Div Canc Epidemiol & Genet, Rockville, MD USA. [Jacobs, Kevin B.; Yeager, Meredith; Zhou, Weiyin; Wang, Zhaoming; Hutchinson, Amy; Deng, Xiang; Liu, Chenwei; Cullen, Michael; Burdett, Laurie] NCI, Core Genotyping Facil, SAIC Frederick Inc, Frederick, MD 21701 USA. [Rodriguez-Santiago, Benjamin; Villa, Olaya; Real, Francisco X.; Perez-Jurado, Luis A.] Univ Pompeu Fabra, Dept Ciencies Expt & Salut, Barcelona, Spain. [Rodriguez-Santiago, Benjamin; Villa, Olaya; Perez-Jurado, Luis A.] Ctr Invest Biomed Red Enfermedades Raras CIBERER, Barcelona, Spain. [Rodriguez-Santiago, Benjamin; Villa, Olaya] qGenomics, Quantitat Genom Med Lab, Barcelona, Spain. [Dean, Michael C.] NCI, Expt Immunol Lab, Ctr Canc Res, Frederick, MD 21701 USA. [Gapstur, Susan M.; Stevens, Victoria L.; Teras, Lauren T.; Gaudet, Mia M.] Amer Canc Soc, Epidemiol Res Program, Atlanta, GA 30329 USA. [Virtamo, Jarmo] Natl Inst Hlth & Welf, Dept Chron Dis Prevent, Helsinki, Finland. [Yuan, Jian-Min] Univ Minnesota, Sch Publ Hlth, Dept Epidemiol & Community Hlth, Minneapolis, MN USA. [Yuan, Jian-Min] Univ Pittsburgh, Inst Canc, Pittsburgh, PA USA. [Ding, Ti; Tang, Ze-Zhong] Shanxi Canc Hosp, Taiyuan, Peoples R China. [Qiao, You-Lin; Fan, Jin-Hu] Chinese Acad Med Sci, Dept Epidemiol, Canc Inst Hosp, Beijing 100730, Peoples R China. [Gao, Yu-Tang; Xiang, Yong-Bing] Shanghai Canc Inst, Shanghai, Peoples R China. [Koh, Woon-Puay] Natl Univ Singapore, Saw Swee Hock Sch Publ Hlth, Singapore 117548, Singapore. [Aldrich, Melinda C.] Vanderbilt Univ, Sch Med, Dept Thorac Surg, Nashville, TN 37212 USA. [Aldrich, Melinda C.; Blot, William J.; Signorello, Lisa B.; Shu, Xiao-Ou; Zheng, Wei] Vanderbilt Univ, Med Ctr, Dept Med, Div Epidemiol,Vanderbilt Epidemiol Ctr, Nashville, TN USA. [Amos, Christopher; Wu, Xifeng] Univ Texas MD Anderson Canc Ctr, Dept Epidemiol, Div Canc Prevent & Populat Sci, Houston, TX 77030 USA. [Blot, William J.; Signorello, Lisa B.] Int Epidemiol Inst, Rockville, MD USA. [Bock, Cathryn H.; Schwartz, Ann G.] Wayne State Univ, Karmanos Canc Inst, Detroit, MI USA. [Bock, Cathryn H.; Schwartz, Ann G.] Wayne State Univ, Sch Med, Dept Oncol, Detroit, MI USA. [Gillanders, Elizabeth M.; Zanetti, Krista A.] NCI, Div Canc Control & Populat Sci, Bethesda, MD 20892 USA. [Harris, Curtis C.; Zanetti, Krista A.] NCI, Human Carcinogenesis Lab, Ctr Canc Res, Bethesda, MD 20892 USA. [Haiman, Christopher A.; Henderson, Brian E.; McKean-Cowdin, Roberta; Schumacher, Fredrick; Stram, Daniel; Barkauskas, Donald A.] Univ So Calif, Keck Sch Med, Dept Prevent Med, Norris Comprehens Canc Ctr, Los Angeles, CA 90033 USA. [Kolonel, Laurence N.; Le Marchand, Loic] Univ Hawaii, Ctr Canc, Program Epidemiol, Honolulu, HI 96822 USA. [McNeill, Lorna H.] Univ Texas MD Anderson Canc Ctr, Dept Hlth Dispar Res, Div Off Vice President Canc Prevent & Populat Sci, Houston, TX 77030 USA. [McNeill, Lorna H.] Univ Texas MD Anderson Canc Ctr, Ctr Community Engaged & Translat Res, Duncan Family Inst, Houston, TX 77030 USA. [Rybicki, Benjamin A.] Henry Ford Hosp, Dept Publ Hlth Sci, Detroit, MI 48202 USA. [Signorello, Lisa B.; Shu, Xiao-Ou; Zheng, Wei] Vanderbilt Univ, Sch Med, Vanderbilt Ingram Canc Ctr, Nashville, TN 37212 USA. [Spitz, Margaret R.] Baylor Coll Med, Dan L Duncan Canc Ctr, Houston, TX 77030 USA. 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[Buring, Julie E.; Gaziano, J. Michael; Sesso, Howard D.] Harvard Univ, Brigham & Womens Hosp, Div Prevent Med, Sch Med, Boston, MA 02115 USA. [Butler, Mary A.; Carreon, Tania; Ruder, Avima M.] NIOSH, Ctr Dis Control & Prevent, Cincinnati, OH 45226 USA. [Feychting, Maria; Ahlbom, Anders] Karolinska Inst, Inst Environm Med, Div Epidemiol, S-10401 Stockholm, Sweden. [Gaziano, J. Michael] Harvard Univ, Sch Med, Div Aging, Brigham & Womens Hosp, Boston, MA 02115 USA. [Gaziano, J. Michael] Vet Affairs Boston Healthcare Syst, Geriatr Res Educ & Clin Ctr, Massachusetts Vet Epidemiol Res & Informat Ctr, Boston, MA USA. [Giles, Graham G.; Severi, Gianluca] Canc Council Victoria, Canc Epidemiol Ctr, Melbourne, Vic, Australia. [Giles, Graham G.; Severi, Gianluca] Univ Melbourne, Ctr Mol Environm Genet & Analyt Epidemiol, Melbourne, Vic, Australia. [Hallmans, Goran] Umea Univ, Dept Publ Hlth & Clin Med, Umea, Sweden. [Hankinson, Susan E.; Wolpin, Brian M.; Fuchs, Charles S.; Giovannucci, Edward L.; Kraft, Peter; Hunter, David J.] Harvard Univ, Sch Med, Channing Lab, Dept Med,Brigham & Womens Hosp, Boston, MA 02115 USA. [Henriksson, Roger] Karolinska Univ Hosp, Dept Oncol, Stockholm, Sweden. [Johansen, Christoffer; Tjonneland, Anne] Danish Canc Soc, Inst Canc Epidemiol, Copenhagen, Denmark. [Michaud, Dominique S.; Riboli, Elio] Univ London Imperial Coll Sci Technol & Med, Sch Publ Hlth, Div Epidemiol & Biostat, London, England. [Michaud, Dominique S.] Brown Univ, Div Biol & Med, Dept Epidemiol, Providence, RI 02912 USA. [Peters, Ulrike; White, Emily; Kooperberg, Charles; LaCroix, Andrea; Mandelson, Margaret T.] Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Seattle, WA 98104 USA. [Peters, Ulrike; White, Emily] Univ Washington, Dept Epidemiol, Seattle, WA 98195 USA. [Visvanathan, Kala; Bolton, Judith A. Hoffman] Johns Hopkins Univ, Dept Epidemiol, Bloomberg Sch Publ Hlth, Baltimore, MD USA. [Wolk, Alicja] Karolinska Inst, Inst Environm Med, Div Nutr Epidemiol, S-10401 Stockholm, Sweden. [Zeleniuch-Jacquotte, Anne] NYU, Dept Environm Med, Sch Med, Div Epidemiol, New York, NY 10016 USA. [Kogevinas, Manolis] Natl Sch Publ Hlth, Athens, Greece. [Kogevinas, Manolis; Gonzalez, Juan R.] Ctr Res Environm Epidemiol CREAL, Barcelona, Spain. [Kogevinas, Manolis; Gonzalez, Juan R.] IMIM, Barcelona, Spain. [Kogevinas, Manolis; Gonzalez, Juan R.] CIBERESP, Barcelona, Spain. [Li, Donghui; Hassan, Manal] Univ Texas MD Anderson Canc Ctr, Dept Gastrointestinal Med Oncol, Houston, TX 77030 USA. [Duell, Eric J.] Inst Invest Biomed Bellvitge IDIBELL, Catalan Inst Oncol ICO, Barcelona, Spain. [Risch, Harvey A.; Yu, Herbert] Yale Univ, Sch Publ Hlth, New Haven, CT USA. [Olson, Sara H.] Mem Sloan Kettering Canc Ctr, Dept Epidemiol & Biostat, New York, NY 10021 USA. [Wolpin, Brian M.; Fuchs, Charles S.] Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA. [Jiao, Li] Baylor Coll Med, Dept Med, Houston, TX 77030 USA. [Wheeler, William] Informat Management Serv Inc, Silver Spring, MD USA. [Arslan, Alan A.] NYU, Dept Obstet & Gynecol, Sch Med, New York, NY 10016 USA. [Arslan, Alan A.] NYU, Dept Environm Med, Sch Med, New York, NY 10016 USA. [Arslan, Alan A.] NYU, Inst Canc, New York, NY USA. [Bueno-de-Mesquita, H. Bas] Univ Med Ctr Utrecht, Dept Gastroenterol & Hepatol, Utrecht, Netherlands. [Bueno-de-Mesquita, H. Bas] Natl Inst Publ Hlth & Environm RIVM, Bilthoven, Netherlands. [Gallinger, Steven; Andrulis, Irene L.; Wunder, Jay S.] Mt Sinai Hosp, Samuel Lunenfeld Res Inst, Fred A Litwin Ctr Canc Genet, Toronto, ON M5G 1X5, Canada. [Gross, Myron D.] Univ Minnesota, Sch Med, Dept Lab Med & Pathol, Minneapolis, MN 55455 USA. [Holly, Elizabeth A.; Bracci, Paige M.] Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA 94143 USA. [Klein, Alison P.; Goggins, Michael] Johns Hopkins Univ, Sch Med, Dept Oncol, Baltimore, MD 21205 USA. [Mandelson, Margaret T.] Grp Hlth Ctr Hlth Studies, Seattle, WA USA. [Petersen, Gloria; Rabe, Kari G.] Mayo Clin, Dept Hlth Sci Res, Rochester, MN USA. [Boutron-Ruault, Marie-Christine] Univ Paris Sud, INSERM, Inst Gustave Roussy, Villejuif, France. [Canzian, Federico] German Canc Res Ctr, Div Canc Epidemiol, Heidelberg, Germany. [Chang, Kenneth] Univ Calif Irvine, Med Ctr, Comprehens Digest Dis Ctr, Orange, CA USA. [Cotterchio, Michelle] Univ Toronto, Dalla Lana Sch Publ Hlth, Toronto, ON, Canada. [Giovannucci, Edward L.; Trichopoulos, Dimitrios; Kraft, Peter; Hunter, David J.] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA. [Giovannucci, Edward L.] Harvard Univ, Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA. [Goggins, Michael] Johns Hopkins Univ, Sch Med, Dept Med, Baltimore, MD 21205 USA. [Goggins, Michael] Johns Hopkins Univ, Sch Med, Dept Pathol, Baltimore, MD 21205 USA. [Jenab, Mazda] Int Agcy Res Canc, World Hlth Org, F-69372 Lyon, France. [Khaw, Kay-Tee] Univ Cambridge, Addenbrookes Hosp, Dept Publ Hlth & Primary Care, Cambridge CB2 2QQ, England. [Krogh, Vittorio] Ist Nazl Tumori, IRCCS, Nutr Epidemiol Unit, I-20133 Milan, Italy. [Kurtz, Robert C.] Mem Sloan Kettering Canc Ctr, Dept Med, New York, NY 10021 USA. [McWilliams, Robert R.] Mayo Clin, Div Med Oncol, Rochester, MN USA. [Trichopoulos, Dimitrios] Acad Athens, Bur Epidemiol Res, Athens, Greece. [Andrulis, Irene L.; Wunder, Jay S.] Mt Sinai Hosp, Christopher Sharp Ctr Surg & Oncol, Toronto, ON M5G 1X5, Canada. [Patino Garcia, Ana; Sierrasesumaga, Luis] Univ Navarra Clin, Dept Pediat, Pamplona, Spain. [Gorlick, Richard G.] Yeshiva Univ, Albert Einstein Coll Med, Dept Mol Pharmacol, Bronx, NY USA. [Gorlick, Richard G.] Yeshiva Univ, Albert Einstein Coll Med, Dept Pediat, Bronx, NY USA. [Schwartz, Kendra L.] Wayne State Univ, Dept Family Med & Publ Hlth Sci, Detroit, MI USA. [Davis, Faith G.] Univ Illinois, Sch Publ Hlth, Div Epidemiol & Biostat, Chicago, IL USA. [Lissowska, Jolanta] Inst Oncol, Warsaw, Poland. [Lissowska, Jolanta] Maria Sklodowska Curie Mem Canc Ctr, Warsaw, Poland. [Peplonska, Beata] Nofer Inst Occupat Med, Lodz, Poland. [Kratz, Christian P.] Hannover Med Sch, Klin Padiatr Hematol & Onkol, Zentrum Kinderheilkunde & Jugendmed, D-30623 Hannover, Germany. [Erickson, Ralph L.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Thomas, Gilles] Univ Lyon 1, Ctr Leon Berard, F-69365 Lyon, France. [Real, Francisco X.] CNIO, Epithelial Carcinogenesis Grp, Madrid, Spain. RP Chanock, SJ (reprint author), NCI, Div Canc Epidemiol & Genet, Rockville, MD USA. EM chanocks@mail.nih.gov RI Tucker, Margaret/B-4297-2015; Albanes, Demetrius/B-9749-2015; Abnet, Christian/C-4111-2015; Garcia-Closas, Montserrat /F-3871-2015; Boutron-Ruault, Marie-Christine/H-3936-2014; Brinton, Louise/G-7486-2015; Freedman, Neal/B-9741-2015; Malats, Nuria/H-7041-2015; Perez Jurado, Luis Alberto/M-7706-2015; Real Arribas, Francisco/H-5275-2015; Savage, Sharon/B-9747-2015; Krogh, Vittorio/K-2628-2016; Qiao, You-Lin/B-4139-2012; Dean, Michael/G-8172-2012; Ruder, Avima/I-4155-2012; Patino-Garcia, Ana/I-4299-2012; Peplonska, Beata/F-6004-2010; Aldrich, Melinda/C-7783-2013; Cook, Michael/A-5641-2009; Gallinger, Steven/E-4575-2013; Andrulis, Irene/E-7267-2013; Boutron Ruault, Marie-Christine/G-3705-2013; Boutron, Marie-Christine/K-8168-2013; Michaud, Dominique/I-5231-2014; Berg , Christine/K-1047-2014; Consonni, Dario/K-7943-2016; Amundadottir, Laufey/L-7656-2016; Tobias, Geoffrey/M-4135-2016; Beane Freeman, Laura/C-4468-2015; Kogevinas, Manolis/C-3918-2017; bertazzi, pietro alberto/D-5039-2017; OI Lissowska, Jolanta/0000-0003-2695-5799; Yuan, Jian-Min/0000-0002-4620-3108; Giles, Graham/0000-0003-4946-9099; Zeleniuch-Jacquotte, Anne/0000-0001-9350-1303; Abnet, Christian/0000-0002-3008-7843; Garcia-Closas, Montserrat /0000-0003-1033-2650; Brinton, Louise/0000-0003-3853-8562; Freedman, Neal/0000-0003-0074-1098; Malats, Nuria/0000-0003-2538-3784; Real Arribas, Francisco/0000-0001-9501-498X; Savage, Sharon/0000-0001-6006-0740; Krogh, Vittorio/0000-0003-0122-8624; Qiao, You-Lin/0000-0001-6380-0871; Dean, Michael/0000-0003-2234-0631; Ruder, Avima/0000-0003-0419-6664; Cook, Michael/0000-0002-0533-7302; Consonni, Dario/0000-0002-8935-3843; Amundadottir, Laufey/0000-0003-1859-8971; Tobias, Geoffrey/0000-0002-2878-8253; Beane Freeman, Laura/0000-0003-1294-4124; bertazzi, pietro alberto/0000-0003-3475-2449; Duell, Eric J/0000-0001-5256-0163; Rodriguez-Santiago, Benjamin/0000-0003-1167-3852; Prokunina-Olsson, Ludmila/0000-0002-9622-2091; Liao, Linda/0000-0002-1923-5294 FU Intramural Research Program; US National Institutes of Health (NIH), NCI [HHSN261200800001E] FX This research was supported by the Intramural Research Program and by contract number HHSN261200800001E of the US National Institutes of Health (NIH), NCI. Support for each contributing study is listed in the Supplementary Note. We thank C. Laurie and B. Weir for constructive discussion and a comparison of methodology and results for the GENEVA study. The findings and conclusions in this report are those of the authors and do not necessarily represent the views of the National Cancer Institute, the National Institute for Occupational Safety and Health or the Maryland Cancer Registry. NR 43 TC 168 Z9 169 U1 2 U2 61 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 1061-4036 EI 1546-1718 J9 NAT GENET JI Nature Genet. PD JUN PY 2012 VL 44 IS 6 BP 651 EP U68 DI 10.1038/ng.2270 PG 10 WC Genetics & Heredity SC Genetics & Heredity GA 949BT UT WOS:000304551100011 PM 22561519 ER PT J AU Allison, SOD Javitt, MC Glanc, P Andreotti, RF Bennett, GL Brown, DL Dubinsky, T Harisinghani, MG Harris, RD Mitchell, DG Pandharipande, PV Pannu, HK Podrasky, AE Shipp, TD Siegel, CL Simpson, L Wong-You-Cheong, JJ Zelop, CM AF Allison, Sandra O. DeJesus Javitt, Marcia C. Glanc, Phyllis Andreotti, Rochelle F. Bennett, Genevieve L. Brown, Douglas L. Dubinsky, Theodore Harisinghani, Mukesh G. Harris, Robert D. Mitchell, Donald G. Pandharipande, Pari V. Pannu, Harpreet K. Podrasky, Ann E. Shipp, Thomas D. Siegel, Cary Lynn Simpson, Lynn Wong-You-Cheong, Jade J. Zelop, Carolyn M. TI ACR Appropriateness Criteria (R) Multiple Gestations SO ULTRASOUND QUARTERLY LA English DT Article DE appropriateness criteria; twin; triplet; multiple gestations ID TWIN TRANSFUSION SYNDROME; BIRTH-WEIGHT DISCORDANCE; FETAL WEIGHT; SONOGRAPHIC PREDICTION; ANTEPARTUM MANAGEMENT; NUCHAL TRANSLUCENCY; GROWTH DISCORDANCE; TRANSVAGINAL ULTRASONOGRAPHY; CHORIONICITY DETERMINATION; 1ST-TRIMESTER ULTRASOUND AB Multiple gestations are high-risk compared with singleton pregnancies. Prematurity and intrauterine growth restrictions are the major sources of morbidity and mortality common to all twin gestations. Monochorionic twins are at a higher risk for twin-twin transfusion, fetal growth restriction, congenital anomalies, vasa previa, velamentous insertion of the umbilical cord and fetal death. Therefore, determination of multiple gestation, amnionicity and chorionicity in the first trimester is important. Follow up examinations to evaluate fetal well-being include assessment of fetal growth and amniotic fluid volume, umbilical artery Doppler, nonstress test and biophysical profile. To date, there is a paucity of literature regarding imaging schedules for follow-up. At the very least, antepartum testing in multiple gestations is recommended in all situations in which surveillance would ordinarily be performed in a singleton pregnancy. The ACR Appropriateness Criteria (R) are evidence-based guidelines for specific clinical conditions that are reviewed biennially by a multidisciplinary expert panel. The guideline development and review include an extensive analysis of current medical literature from peer reviewed journals and the application of a well-established consensus methodology (modified Delphi) to rate the appropriateness of imaging procedures by the panel. In those instances where evidence is lacking or not definitive, expert opinion may be used to recommend imaging. C1 [Allison, Sandra O. DeJesus] Georgetown Univ Hosp, Washington, DC 20007 USA. [Javitt, Marcia C.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [Glanc, Phyllis] Sunnybrook Hlth Sci Ctr, Toronto, ON M4N 3M5, Canada. [Andreotti, Rochelle F.] Vanderbilt Univ, Med Ctr, Nashville, TN USA. [Bennett, Genevieve L.] NYU, Med Ctr, New York, NY 10016 USA. [Brown, Douglas L.] Mayo Clin, Rochester, MN USA. [Dubinsky, Theodore] Univ Washington, Sch Med, Seattle, WA USA. [Harisinghani, Mukesh G.; Pandharipande, Pari V.] Massachusetts Gen Hosp, Boston, MA 02114 USA. [Harris, Robert D.] Dartmouth Hitchcock Med Ctr, Lebanon, NH 03766 USA. [Mitchell, Donald G.] Thomas Jefferson Univ Hosp, Philadelphia, PA 19107 USA. [Pannu, Harpreet K.] Mem Sloan Kettering Canc Ctr, New York, NY 10021 USA. [Podrasky, Ann E.] Baptist Hosp Miami, S Miami Ctr Women & Infants, Miami, FL USA. [Shipp, Thomas D.] Diagnost Ultrasound Associates, Boston, MA USA. [Siegel, Cary Lynn] Washington Univ, Med Ctr, Mallinckrodt Inst Radiol, St Louis, MO 63110 USA. [Simpson, Lynn] Columbia Univ, Amer Coll Obstet & Gynecol, New York, NY USA. [Wong-You-Cheong, Jade J.] Univ Maryland, Sch Med, Baltimore, MD 21201 USA. [Zelop, Carolyn M.] Harvard Univ, Beth Israel Deaconess Med Ctr, Sch Med, Boston, MA 02215 USA. RP Allison, SOD (reprint author), Amer Coll Radiol, Dept Qual & Safety, 1891 PrestonWhite Dr, Reston, VA 20191 USA. EM sa263@gunet.georgetown.edu NR 81 TC 4 Z9 4 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0894-8771 J9 ULTRASOUND Q JI Ultrasound Q. PD JUN PY 2012 VL 28 IS 2 BP 149 EP 155 DI 10.1097/RUQ.0b013e31824bfc06 PG 7 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA 948WT UT WOS:000304534600014 ER PT J AU Douglas, TA Walsh, ME Weiss, CA McGrath, CJ Trainor, TP AF Douglas, Thomas A. Walsh, Marianne E. Weiss, Charles A., Jr. McGrath, Christian J. Trainor, Thomas P. TI Desorption and Transformation of Nitroaromatic (TNT) and Nitramine (RDX and HMX) Explosive Residues on Detonated Pure Mineral Phases SO WATER AIR AND SOIL POLLUTION LA English DT Article DE Explosive residues; TNT; RDX; Soil contamination ID CLAY-MINERALS; SOIL; ADSORPTION; SORPTION; 2,4,6-TRINITROTOLUENE; WATER; DEGRADATION; TEMPERATURE; DISSOLUTION; TRANSPORT AB Explosive compounds, including known toxicants 2,4,6-trinitrotoluene (TNT) and hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX), are loaded to soils during military training. Their fate in soils is ultimately controlled by soil mineralogical and biogeochemical processes. We detonated pure mineral phases with Composition B, a mixture of TNT and RDX, and investigated the fate of detonation residues in aqueous slurries constructed from the detonated minerals. The pure minerals included Ottawa sand (quartz and calcite), microcline feldspar, phlogopite mica, muscovite mica, vermiculite clay, beidellite (a representative of the smectite clay group), and nontronite clay. Energy-dispersive X-ray spectrometry, X-ray diffraction, and gas adsorption surface area measurements were made of the pristine and detonated minerals. Batch slurries of detonated minerals and deionized water were sampled for 141 days and TNT, RDX, and TNT transformation products were measured from the aqueous samples and from the mineral substrates at day 141. Detonated samples generally exhibited lower gas adsorption surface areas than pristine ones, likely from residue coating, shock-induced compaction, sintering, and/or partial fusion. TNT and RDX exhibited analyte loss in almost all batch solutions over time but loss was greater in vermiculite, beidellite, and phlogopite than in muscovite and quartz. This suggests common phyllosilicate mineral substrates could be used on military training ranges to minimize off-site migration of explosive residues. We present a conceptual model to represent the physical and chemical processes that occurred in our aqueous batches over time. C1 [Douglas, Thomas A.] USA, Engn Res & Dev Ctr, Cold Reg Res & Engn Lab, Ft Wainwright, AK 99703 USA. [Walsh, Marianne E.] USA, Engn Res & Dev Ctr, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. [Weiss, Charles A., Jr.] USA, Engn Res & Dev Ctr, Geotech & Struct Lab, Vicksburg, MS 39180 USA. [McGrath, Christian J.] USA, Engn Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA. [Trainor, Thomas P.] Univ Alaska Fairbanks, Dept Chem, Fairbanks, AK 99775 USA. RP Douglas, TA (reprint author), USA, Engn Res & Dev Ctr, Cold Reg Res & Engn Lab, POB 35170, Ft Wainwright, AK 99703 USA. EM thomas.a.douglas@usace.army.mil NR 41 TC 6 Z9 6 U1 4 U2 26 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0049-6979 J9 WATER AIR SOIL POLL JI Water Air Soil Pollut. PD JUN PY 2012 VL 223 IS 5 BP 2189 EP 2200 DI 10.1007/s11270-011-1015-2 PG 12 WC Environmental Sciences; Meteorology & Atmospheric Sciences; Water Resources SC Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences; Water Resources GA 947XF UT WOS:000304467000022 ER PT J AU Farrell, SL Kurtz, N Connor, LN Elder, BC Leuschen, C Markus, T McAdoo, DC Panzer, B Richter-Menge, J Sonntag, JG AF Farrell, Sinead Louise Kurtz, Nathan Connor, Laurence N. Elder, Bruce C. Leuschen, Carlton Markus, Thorsten McAdoo, David C. Panzer, Ben Richter-Menge, Jacqueline Sonntag, John G. TI A First Assessment of IceBridge Snow and Ice Thickness Data Over Arctic Sea Ice SO IEEE TRANSACTIONS ON GEOSCIENCE AND REMOTE SENSING LA English DT Article DE Altimetry; geophysical measurement techniques; remote sensing; sea ice; snow ID LASER ALTIMETER MEASUREMENTS; AIRBORNE LASER; RADAR MEASUREMENTS; DEPTH; VARIABILITY; VALIDATION; CAMPAIGN; SHEBA AB We present a first assessment of airborne laser and radar altimeter data over snow-covered sea ice, gathered during the National Aeronautics and Space Administration Operation IceBridge Mission. We describe a new technique designed to process radar echograms fromthe University of Kansas snow radar to estimate snow depth. We combine IceBridge laser altimetry with radar-derived snow depths to determine sea ice thickness. Results are validated through comparison with direct measurements of snow and ice thickness collected in situ at the Danish GreenArc 2009 sea ice camp located on fast ice north of Greenland. The IceBridge instrument suite provides accurate measurements of snow and ice thickness, particularly over level ice. Mean IceBridge snow and ice thickness agree with in situ measurements to within similar to 0.01 and similar to 0.05 m, respectively, while modal snow and ice thickness estimates agree to within 0.02 and 0.10 m, respectively. IceBridge snow depths were correlated with in situ measurements (R = 0.7, for an averaging length of 55 m). The uncertainty associated with the derived IceBridge sea ice thickness estimates is 0.40 m. The results demonstrate the retrieval of both first-year and multiyear ice thickness from IceBridge data. The airborne data were however compromised in heavily ridged ice where snow depth, and hence ice thickness, could not be measured. Techniques developed as part of this study will be used for routine processing of IceBridge retrievals over Arctic sea ice. The limitations of the GreenArc study are discussed, and recommendations for future validation of airborne measurements via field activities are provided. C1 [Farrell, Sinead Louise] Univ Maryland, Earth Syst Sci Interdisciplinary Ctr, College Pk, MD 20740 USA. [Kurtz, Nathan] Univ Maryland Baltimore Cty, NASA, Joint Ctr Earth Syst Technol, Baltimore, MD 21250 USA. [Kurtz, Nathan; Markus, Thorsten] NASA, Hydrospher & Biospher Sci Lab, Goddard Space Flight Ctr, Greenbelt, MD 20771 USA. [Connor, Laurence N.; McAdoo, David C.] Natl Ocean & Atmospher Adm, Lab Satellite Altimetry, Satellite Oceanog & Climatol Div, Silver Spring, MD 20910 USA. [Elder, Bruce C.; Richter-Menge, Jacqueline] USA, Cold Reg Res & Engn Lab, Corps Engineers, Hanover, NH 03755 USA. [Leuschen, Carlton; Panzer, Ben] Univ Kansas, Ctr Remote Sensing Ice Sheets, Lawrence, KS 66045 USA. [Sonntag, John G.] URS Corp, NASA, Wallops Flight Facil, Wallops Isl, VA 23337 USA. RP Farrell, SL (reprint author), Univ Maryland, Earth Syst Sci Interdisciplinary Ctr, College Pk, MD 20740 USA. EM sineadf@umd.edu; nathan.t.kurtz@nasa.gov; laurence.connor@noaa.gov; Bruce.C.Elder@usace.army.mil; leuschen@cresis.ku.edu; thorsten.markus@nasa.gov; dave.mcadoo@noaa.gov; bpanzer@ku.edu; Jacqueline.A.Richter-Menge@usace.army.mil; john.g.sonntag@nasa.gov RI Connor, Laurence/E-7930-2011; Farrell, Sinead/F-5586-2010; McAdoo, Dave/F-5612-2010 OI Connor, Laurence/0000-0002-5276-6257; Farrell, Sinead/0000-0003-3222-2751; McAdoo, Dave/0000-0002-7533-5564 FU NOAA; NASA FX This work was supported by NOAA, and the NASA Cryospheric Sciences Program. The views, opinions, and findings contained in this report are those of the authors and should not be construed as an official National Oceanic and Atmospheric Administration or US Government position, policy, or decision. NR 34 TC 24 Z9 24 U1 4 U2 34 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0196-2892 J9 IEEE T GEOSCI REMOTE JI IEEE Trans. Geosci. Remote Sensing PD JUN PY 2012 VL 50 IS 6 BP 2098 EP 2111 DI 10.1109/TGRS.2011.2170843 PG 14 WC Geochemistry & Geophysics; Engineering, Electrical & Electronic; Remote Sensing; Imaging Science & Photographic Technology SC Geochemistry & Geophysics; Engineering; Remote Sensing; Imaging Science & Photographic Technology GA 945AZ UT WOS:000304246500002 ER PT J AU Eberly, J Ely, R AF Eberly, Jed O. Ely, Roger L. TI Photosynthetic accumulation of carbon storage compounds under CO2 enrichment by the thermophilic cyanobacterium Thermosynechococcus elongatus SO JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY LA English DT Article ID POLY-BETA-HYDROXYBUTYRATE; MASS-TRANSFER; MICROALGAE; DIOXIDE; FIXATION; BIOFUELS; GLYCOGEN; PHOTOBIOREACTOR; PURIFICATION; BIOREACTOR AB The growth characteristics of Thermosynechococcus elongatus on elevated CO2 were studied in a photobioreactor. Cultures were able to grow on up to 20% CO2. The maximum productivity and CO2 fixation rates were 0.09 +/- A 0.01 and 0.17 +/- A 0.01 mg ml(-1) day(-1), respectively, for cultures grown on 20% CO2. Three major carbon pools-lipids, polyhydroxybutyrates (PHBs), and glycogen-were measured. These carbon stores accounted for 50% of the total biomass carbon in cultures grown on atmospheric CO2 (no supplemental CO2), but only accounted for 30% of the total biomass carbon in cultures grown on 5-20% CO2. Lipid content was approximately 20% (w/w) under all experimental conditions, while PHB content reached 14.5% (w/w) in cultures grown on atmospheric CO2 and decreased to approximately 2.0% (w/w) at 5-20% CO2. Glycogen levels did not vary significantly and remained about 1.4% (w/w) under all test conditions. The maximum amount of CO2 sequestered over the course of the nine-day chemostat experiment was 1.15 g l(-1) in cultures grown on 20% CO2. C1 [Eberly, Jed O.] USA, Environm Lab, CEERDC EP P, Engn Res & Dev Ctr, Vicksburg, MS 39180 USA. [Eberly, Jed O.] Oregon State Univ, Dept Biol & Ecol Engn, Corvallis, OR 97331 USA. RP Eberly, J (reprint author), USA, Environm Lab, CEERDC EP P, Engn Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM Jed.O.Eberly@usace.army.mil FU DOD/ASEE SMART FX We would like to thank Dr. Elizabeth Burrows for her technical assistance in setting up and troubleshooting the bioreactors. This work was supported in part by the DOD/ASEE SMART scholarship program. Special thanks to Markael Luterra for editorial assistance. NR 45 TC 6 Z9 6 U1 4 U2 28 PU SPRINGER HEIDELBERG PI HEIDELBERG PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY SN 1367-5435 J9 J IND MICROBIOL BIOT JI J. Ind. Microbiol. Biotechnol. PD JUN PY 2012 VL 39 IS 6 BP 843 EP 850 DI 10.1007/s10295-012-1092-2 PG 8 WC Biotechnology & Applied Microbiology SC Biotechnology & Applied Microbiology GA 947BS UT WOS:000304402200004 PM 22383176 ER PT J AU Grujicic, M Pandurangan, B Zhang, Z Bell, WC Gazonas, GA Patel, P Cheeseman, BA AF Grujicic, M. Pandurangan, B. Zhang, Z. Bell, W. C. Gazonas, G. A. Patel, P. Cheeseman, B. A. TI Molecular-Level Analysis of Shock-Wave Physics and Derivation of the Hugoniot Relations for Fused Silica SO JOURNAL OF MATERIALS ENGINEERING AND PERFORMANCE LA English DT Article DE fused silica; Hugoniots; non-equilibrium molecular-dynamics simulations; shock waves ID BRITTLE MATERIALS; FORCE-FIELD; DYNAMICS; MODEL; GLASS; PRESSURE; FRAGMENTATION; TRANSITION; POLYUREA; COMPASS AB Equilibrium and non-equilibrium molecular-dynamics simulations are employed in this study to investigate various aspects of shock waves in fused silica (a pure SiO2 amorphous material used in transparent-armor applications). Equilibrium molecular-dynamics simulations are used first to validate that the initial (unshocked) fused silica possesses the appropriate mass density and microstructure (as characterized by its partial Si-Si, Si-O, and O-O radial distribution functions). Next, non-equilibrium molecular-dynamics simulations are employed, within a continuously contracting computational-cell scheme, to generate planar longitudinal (uniaxial motion) shocks of different strengths. By examining and quantifying the dynamics of shock-wave motion, the respective shock-Hugoniot relations (i.e., functional relations between various material-state variables in the material states produced by the shocks of different strengths) are determined. This methodology suggested that irreversible non-equilibrium deformation/damage processes play an important role in the mechanical response of fused silica to shock loading and that the "equilibrium" procedures for Hugoniot determination based on the equation of state and the Rankine-Hugoniot equation may not be fully justified. Finally, the non-equilibrium molecular-dynamics simulations were used to identify the main microstructure modifying/altering processes accompanying the shock-wave motion through fused silica. C1 [Grujicic, M.; Pandurangan, B.; Zhang, Z.; Bell, W. C.] Clemson Univ, Dept Mech Engn, Clemson, SC 29634 USA. [Gazonas, G. A.; Patel, P.; Cheeseman, B. A.] USA, Army Res Lab Survivabil, Mat Branch, Aberdeen Proving Ground, MD 21005 USA. RP Grujicic, M (reprint author), Clemson Univ, Dept Mech Engn, 241 Engn Innovat Bldg, Clemson, SC 29634 USA. EM gmica@clemson.edu OI Gazonas, George/0000-0002-2715-016X FU U.S. Army/Clemson University [W911NF-04-2-0024, W911NF-06-2-0042]; Army Research Office (ARO) [W911NF-09-1-0513] FX The research material presented in this article is based on study supported by the U.S. Army/Clemson University Cooperative Agreements W911NF-04-2-0024 and W911NF-06-2-0042 and by the Army Research Office (ARO) research contract entitled "Multi-length Scale Material Model Development for Armorgrade Composites,'' Contract Number W911NF-09-1-0513. NR 42 TC 8 Z9 8 U1 2 U2 20 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1059-9495 EI 1544-1024 J9 J MATER ENG PERFORM JI J. Mater. Eng. Perform. PD JUN PY 2012 VL 21 IS 6 BP 823 EP 836 DI 10.1007/s11665-011-0005-2 PG 14 WC Materials Science, Multidisciplinary SC Materials Science GA 944ZB UT WOS:000304241200005 ER PT J AU Villamaria, C Rasmussen, T Spencer, J Davis, M AF Villamaria, Carole Rasmussen, Todd Spencer, Jerry Davis, Michael TI Microvascular Porcine Model for the Optimization of Composite Tissue AutoTransplantation SO JOURNAL OF VASCULAR SURGERY LA English DT Meeting Abstract CT Vascular Annual Meeting of the Society-for-Vascular-Surgery (SVS) CY JUN 07-09, 2012 CL Natl Harbor, MD SP Soc Vasc Surg (SVS) C1 [Villamaria, Carole; Rasmussen, Todd; Spencer, Jerry; Davis, Michael] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0741-5214 J9 J VASC SURG JI J. Vasc. Surg. PD JUN PY 2012 VL 55 IS 6 SU S BP 4 EP 5 PG 2 WC Surgery; Peripheral Vascular Disease SC Surgery; Cardiovascular System & Cardiology GA 947AL UT WOS:000304398900004 ER PT J AU Simon, TE Naig, AL Brockmeyer, JR Rice, RD Prasad, BM White, PW AF Simon, Todd E. Naig, Anna L. Brockmeyer, Joel R. Rice, Robert D. Prasad, Balakrishna M. White, Paul W. TI Evaluation of Porcine Dermal Collagen (Permacol) as an Alternative Vascular Conduit for Interposition Grafting in the Presence of Bacterial Contamination in a Rabbit Model SO JOURNAL OF VASCULAR SURGERY LA English DT Meeting Abstract CT Vascular Annual Meeting of the Society-for-Vascular-Surgery (SVS) CY JUN 07-09, 2012 CL Natl Harbor, MD SP Soc Vasc Surg (SVS) C1 [Simon, Todd E.; Naig, Anna L.; Brockmeyer, Joel R.; Rice, Robert D.; White, Paul W.] Dwight D Eisenhower Army Med Ctr, Peripheral Vasc Surg Serv, Ft Gordon, GA USA. [Prasad, Balakrishna M.] Dwight D Eisenhower Army Med Ctr, Dept Clin Invest, Ft Gordon, GA USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0741-5214 J9 J VASC SURG JI J. Vasc. Surg. PD JUN PY 2012 VL 55 IS 6 SU S BP 80 EP 81 PG 2 WC Surgery; Peripheral Vascular Disease SC Surgery; Cardiovascular System & Cardiology GA 947AL UT WOS:000304398900156 ER PT J AU Sperry, JH Weatherhead, PJ AF Sperry, J. H. Weatherhead, P. J. TI Individual and sex-based differences in behaviour and ecology of rat snakes in winter SO JOURNAL OF ZOOLOGY LA English DT Article DE Elaphe obsoleta; winter ecology; individual behaviour; habitat use; thermoregulation; activity ID JERSEY PINE BARRENS; ELAPHE-OBSOLETA; THERMAL ECOLOGY; ANTIPREDATOR BEHAVIOR; SEASONAL ACTIVITY; TEXAS RATSNAKES; COLOR PATTERN; HABITAT USE; TEMPERATURE; HIBERNACULA AB Most research on the winter ecology of temperate-zone snakes is restricted to aspects of hibernation, because that is largely how snakes spend the winter. At lower latitudes, however, the same snake species may be active during winter, although why they are active and how much individuals vary in activity is unknown. We used radio-telemetry data from three winters to document winter movements of 30 rat snakes (Elaphe obsoleta) in Texas. Snakes moved in all months, although there was substantial individual and gender-based variation. Consistent with active snakes foraging, monthly variation in movement was associated with availability of thermal windows that would allow digestion of a meal. Females were more active than males, suggesting increased foraging demands. Individual activity in winter was positively correlated with activity the previous summer, particular among females. This may reflect enduring effects of variation in reproductive costs, or intrinsic variation in activity of individual snakes. Variation in activity was associated with differences in habitat use but not thermoregulation, although the data available to assess thermoregulation allowed limited resolution. Climate warming will increase the thermal opportunities for winter foraging, which will have implications both for snakes and their prey. C1 [Sperry, J. H.] Engineer Res & Dev Ctr, Champaign, IL 61826 USA. [Sperry, J. H.; Weatherhead, P. J.] Univ Illinois, Program Ecol Evolut & Conservat Biol, Champaign, IL 61820 USA. RP Sperry, JH (reprint author), Engineer Res & Dev Ctr, POB 9005, Champaign, IL 61826 USA. EM Jinelle.sperry@usace.army.mil FU Construction Engineering Research Laboratory of the Engineer Research Development Center (ERDC); US Army FX Funding for this project was provided by the Construction Engineering Research Laboratory of the Engineer Research Development Center (ERDC) and by the US Army through an agreement between the Natural Resources Management Branch at Fort Hood, US Army ERDC and University of Illinois. We thank T. Hayden and J. Cornelius for help in arranging funding, as well as C. Taylor and numerous field biologists for field assistance. NR 37 TC 3 Z9 3 U1 2 U2 23 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0952-8369 J9 J ZOOL JI J. Zool. PD JUN PY 2012 VL 287 IS 2 BP 142 EP 149 DI 10.1111/j.1469-7998.2011.00895.x PG 8 WC Zoology SC Zoology GA 945TY UT WOS:000304300300008 ER PT J AU Buenaver, LF Quartana, PJ Grace, EG Sarlani, E Simango, M Edwards, RR Haythornthwaite, JA Smith, MT AF Buenaver, Luis F. Quartana, Phillip J. Grace, Edward G. Sarlani, Eleni Simango, Mpepera Edwards, Robert R. Haythornthwaite, Jennifer A. Smith, Michael T. TI Evidence for indirect effects of pain catastrophizing on clinical pain among myofascial temporomandibular disorder participants: The mediating role of sleep disturbance SO PAIN LA English DT Article DE Bootstrapping; Catastrophizing; Chronic pain; Insomnia; Mediation; Sleep disturbance; Temporomandibular joint disorder ID COGNITIVE-BEHAVIORAL THERAPY; NEUROCOGNITIVE CONSEQUENCES; INFLAMMATORY MARKERS; INSOMNIA SECONDARY; DEPRIVATION; DEPRESSION; RESPONSES; INVENTORY; SCALE; OSTEOARTHRITIS AB Sleep disturbance and pain catastrophizing are important mediators of the chronic pain experience. To date, these factors have not been considered concurrently despite compelling theoretical rationale to do so. In the present study, we examined whether pain catastrophizing not only has direct effects on clinical pain and pain-related interference, but also indirect effects through its association with sleep disturbance. We evaluated this hypothesis using a cohort (n = 214) of myofascial temporomandibular disorder participants using a statistical bootstrapping technique recommended for tests of indirect effects. Results suggested that pain catastrophizing was associated with greater sleep disturbance, and that a significant portion of variance in clinical pain severity and pain-related interference attributable to pain catastrophizing was mediated by sleep disturbance. Supplementary analyses revealed that the rumination component of catastrophizing seemed to be indirectly related to clinical outcomes through sleep disturbance. No evidence for indirect effects was observed for helplessness and magnification components. These results suggest that rumination about pain may contribute to clinical pain indirectly through alterations in sleep. Prospective studies are needed to examine lagged associations between these constructs. These findings have important theoretical and clinical implications. Critically, interventions that reduce pain catastrophizing may concurrently improve sleep and clinical pain. (C) 2012 International Association for the Study of Pain. Published by Elsevier B. V. All rights reserved. C1 [Buenaver, Luis F.; Simango, Mpepera; Haythornthwaite, Jennifer A.; Smith, Michael T.] Johns Hopkins Univ, Sch Med, Dept Psychiat & Behav Sci, Baltimore, MD 21205 USA. [Quartana, Phillip J.] Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci, Silver Spring, MD USA. [Grace, Edward G.] Univ Maryland, Sch Dent, Dept Neural & Pain Sci, Baltimore, MD 21201 USA. [Edwards, Robert R.] Harvard Univ, Sch Med, Dept Anesthesia, Brigham & Womens Pain Management Ctr, Boston, MA 02115 USA. RP Buenaver, LF (reprint author), 5510 Nathan Shock Dr,Suite 100, Baltimore, MD 21224 USA. EM lbuenav1@jhmi.edu FU NIH [F32DE017282, R01DE13906, 5R24AT004641, R01AR05487, 3R01AR054871-02S1, NS47168] FX This work was supported in part by NIH Grants F32DE017282 (LFB), R01DE13906 (JAH, MTS, REE, EG, ES), 5R24AT004641 (JAH, LFB), R01AR05487 (MTS), 3R01AR054871-02S1 (MTS), and NS47168 (MTS). NR 80 TC 25 Z9 25 U1 2 U2 9 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0304-3959 J9 PAIN JI Pain PD JUN PY 2012 VL 153 IS 6 BP 1159 EP 1166 DI 10.1016/j.pain.2012.01.023 PG 8 WC Anesthesiology; Clinical Neurology; Neurosciences SC Anesthesiology; Neurosciences & Neurology GA 945BZ UT WOS:000304249100010 PM 22417656 ER PT J AU Barry, BE Ohland, MW AF Barry, B. E. Ohland, M. W. TI ABET Criterion 3.f: How Much Curriculum Content is Enough? SO SCIENCE AND ENGINEERING ETHICS LA English DT Article DE ABET; Ethics; Professionalism; Curriculum; Fundamentals of Engineering Examination ID PERFORMANCE; EDUCATION; OUTCOMES; ETHICS AB Even after multiple cycles of ABET accreditation, many engineering programs are unsure of how much curriculum content is needed to meet the requirements of ABET's Criterion 3.f (an understanding of professional and ethical responsibility). This study represents the first scholarly attempt to assess the impact of curriculum reform following the introduction of ABET Criterion 3.f. This study sought to determine how much professional and ethical responsibility curriculum content was used between 1995 and 2005, as well as how, when, why, and to what effect changes in the amount of content occurred. Subsequently, the study sought to evaluate if different amounts of curriculum content generated differing student outcomes. The amount of curriculum content used by each of the participating programs was identified during semi-structured interviews with program administrators and a review of ABET Self-Study documents. Quantitative methods were applied to determine if a relationship existed between the curriculum content and performance on a nationally administered, engineering-specific standardized examination. The findings indicate a statistical relationship, but a lack of structure between the amount of required content in the curriculum and performance on the examination. Additional findings were also generated regarding the way that programs interpret the Criterion 3.f feedback generated during accreditation visits. The primary impact of this study is that it dispels the myth that more courses or course time on professionalism and ethics will necessarily lead to positive engineering education outcomes. Much of the impetus to add more curriculum content results from a lack of conclusive feedback during ABET accreditation visits. C1 [Barry, B. E.] US Mil Acad, Dept Civil & Mech Engn, West Point, NY 10996 USA. [Ohland, M. W.] Purdue Univ, Sch Engn Educ, W Lafayette, IN 47907 USA. RP Barry, BE (reprint author), US Mil Acad, Dept Civil & Mech Engn, Bldg 752,Mahan Hall, West Point, NY 10996 USA. EM brock.barry@usma.edu OI Ohland, Matthew/0000-0003-4052-1452 FU National Science Foundation [DRL-0729596, EEC-0646441]; Purdue University; Bilsland Dissertation Fellowship FX The MIDFIELD program is supported by the National Science Foundation Grant No. REC-0337629 (now DRL-0729596) and EEC-0646441. Dr. Barry's doctoral program was funded by Purdue University through the Frederick N. Andrews Fellowship and the Bilsland Dissertation Fellowship. The authors gratefully acknowledge the time and resources supplied by representatives of NCEES, particularly Davy McDowell, as well as various administrators and program representatives at the MIDFIELD academic institutions in providing access to various forms of data. The authors would like to express sincere appreciation for the guidance and review provided by Drs. Ruth A. Streveler, Karl A. Smith, and Vincent P. Drnevich, P.E., as well as the assistance provided by Dr. Richard A. Layton, Russell A. Long and Richard G. Martin. NR 49 TC 5 Z9 5 U1 2 U2 12 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 1353-3452 EI 1471-5546 J9 SCI ENG ETHICS JI Sci. Eng. Ethics PD JUN PY 2012 VL 18 IS 2 BP 369 EP 392 DI 10.1007/s11948-011-9255-5 PG 24 WC Ethics; Engineering, Multidisciplinary; History & Philosophy Of Science; Multidisciplinary Sciences; Philosophy SC Social Sciences - Other Topics; Engineering; History & Philosophy of Science; Science & Technology - Other Topics; Philosophy GA 946KW UT WOS:000304351500013 PM 21318324 ER PT J AU Cowan, DN Bedno, SA Urban, N Lee, DS Niebuhr, DW AF Cowan, David N. Bedno, Sheryl A. Urban, Nadia Lee, Dara S. Niebuhr, David W. TI Step Test Performance and Risk of Stress Fractures Among Female Army Trainees SO AMERICAN JOURNAL OF PREVENTIVE MEDICINE LA English DT Article ID EXERCISE-RELATED INJURIES; TRAINING-RELATED INJURIES; MUSCULOSKELETAL INJURIES; PREACCESSION FITNESS; PHYSICAL-ACTIVITY; BODY-COMPOSITION; YOUNG MEN; RECRUITS; MILITARY; WOMEN AB Background: Stress fractures and other musculoskeletal injuries are major sources of morbidity among female military trainees. Several risk factors have been postulated, particularly pre-existing fitness, usually assessed with post-entry run time for >= 1.0 mile. Purpose: Physical fitness is not formally evaluated prior to Army entry. If a valid and simple test that identified women at increased risk of stress fracture were available and could be applied prior to entry, it would facilitate cost-benefit studies of deferral or interventions. These analyses were undertaken to determine if a 5-minute step test conducted before entry identified women at increased risk. Methods: A prospective study was conducted of weight-qualified women entering the Army in 2005-2006, with analyses completed in 2011. At the pre-entry examination, information was collected on age, BMI, smoking, race, and activity level. Everyone took the step test. All outpatient medical encounters were captured, and stress fractures and other musculoskeletal injuries identified. Women with stress fractures and those with other musculoskeletal injuries were evaluated separately. Results: 1568 women were included in the study; 109 developed stress fractures and 803 other musculoskeletal injury. Women who failed the step test had a 76% higher stress fracture incidence and a 35% higher incidence of other musculoskeletal injuries. There was effect modification between age and test failure for stress fracture. Conclusions: A step test that can be administered before military entry identifies women with increased incidence of stress fracture and other musculoskeletal injury. This test could be used pre-entry to defer or target high-risk recruits for tailored fitness training before or after military entrance. (Am J Prev Med 2012; 42(6):620-624) (C) 2012 American Journal of Preventive Medicine C1 [Cowan, David N.; Urban, Nadia; Lee, Dara S.; Niebuhr, David W.] Walter Reed Army Inst Res, Prevent Med Branch, Dept Epidemiol, Silver Spring, MD 20910 USA. [Cowan, David N.; Urban, Nadia] Allied Technol Grp, Rockville, MD USA. [Bedno, Sheryl A.] Dwight D Eisenhower Army Med Ctr, Occupat Hlth Serv, Ft Gordon, GA USA. RP Cowan, DN (reprint author), Walter Reed Army Inst Res, Prevent Med Branch, Dept Epidemiol, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM David.Cowan@amedd.army.mil FU U.S. Army Accession Command; U.S. Army National Guard Bureau FX This study was funded by the U.S. Army Accession Command and the U.S. Army National Guard Bureau. NR 39 TC 12 Z9 12 U1 2 U2 14 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0749-3797 J9 AM J PREV MED JI Am. J. Prev. Med. PD JUN PY 2012 VL 42 IS 6 BP 620 EP 624 DI 10.1016/j.amepre.2012.02.014 PG 5 WC Public, Environmental & Occupational Health; Medicine, General & Internal SC Public, Environmental & Occupational Health; General & Internal Medicine GA 942ZT UT WOS:000304090900012 PM 22608380 ER PT J AU Gupta, A Kim, BC Edwards, E Brantley, C Ruffin, P AF Gupta, Anurag Kim, Bruce C. Edwards, Eugene Brantley, Christina Ruffin, Paul TI Synthesis and functionalization study of hierarchical ZnO nanowires for potential nitroaromatic sensing applications SO APPLIED PHYSICS A-MATERIALS SCIENCE & PROCESSING LA English DT Article ID PHOTOVOLTAIC DEVICES; GAS SENSORS; OXIDE; NANORODS; FILM; SEMICONDUCTOR; TEMPLATE; CATALYST; GROWTH; ARRAY AB In this work, we synthesize hierarchical ZnO nanowires in a customized atmospheric CVD furnace and investigate their surface modification behavior for prospective nitroaromatic sensing applications. The morphology and crystal structure of pristine nanowires are characterized through FE-SEM, TEM, X-ray diffraction and EDAX studies. Photoluminescence behavior of pristine nanowires is also reported. Surface modification behavior of synthesized nanowires on a ZnO-oleic acid system is studied by utilizing Raman and FT-IR spectroscopy. Based on these findings, 1-pyrenebutyric acid (PBA) has been identified as an appropriate fluorescent receptor for sensing -nitrophenol. Fluorescence quenching experiments on a PBA--nitrophenol system are reported and a detection limit of up to 28 ppb is envisaged for PBA-grafted ZnO nanowire-based optical sensor. C1 [Gupta, Anurag; Kim, Bruce C.] Univ Alabama, Tuscaloosa, AL 35487 USA. [Edwards, Eugene; Brantley, Christina; Ruffin, Paul] USA, RDECOM AMRDEC, Redstone Arsenal, AL 35898 USA. RP Gupta, A (reprint author), Univ Alabama, 101 Houser Hall, Tuscaloosa, AL 35487 USA. EM agupta16@crimson.ua.edu FU U.S. Army, AMRDEC in Huntsville, AL [W31P4Q-09-D-0028] FX This work was partially funded by the U.S. Army Contract No. W31P4Q-09-D-0028, AMRDEC in Huntsville, AL. NR 29 TC 4 Z9 4 U1 1 U2 28 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0947-8396 J9 APPL PHYS A-MATER JI Appl. Phys. A-Mater. Sci. Process. PD JUN PY 2012 VL 107 IS 3 BP 709 EP 714 DI 10.1007/s00339-012-6889-3 PG 6 WC Materials Science, Multidisciplinary; Physics, Applied SC Materials Science; Physics GA 943XC UT WOS:000304159200026 ER PT J AU Kelly, MP Coldren, RL Parish, RV Dretsch, MN Russell, ML AF Kelly, Mark P. Coldren, Rodney L. Parish, Robert V. Dretsch, Michael N. Russell, Michael L. TI Assessment of Acute Concussion in the Combat Environment SO ARCHIVES OF CLINICAL NEUROPSYCHOLOGY LA English DT Article DE Concussion; Military; Neuropsychological testing; Combat; Automated Neuropsychological Assessment Metrics ID TRAUMATIC BRAIN-INJURY; COLLEGIATE FOOTBALL PLAYERS; SPORTS-RELATED CONCUSSION; ASSESSMENT METRICS ANAM; MILD HEAD-INJURY; NEUROPSYCHOLOGICAL ASSESSMENT; NCAA CONCUSSION; SYMPTOM-FREE; MILITARY; RECOVERY AB Despite the prevalence of concussion in soldiers deployed to Iraq and Afghanistan, neuropsychological tests used to assist in concussion management have not been validated on the battlefield. This study evaluated the validity of the Automated Neuropsychological Assessment Metrics (ANAM) in the combat environment. Cases meeting criteria for concussion, healthy controls, and injured controls were assessed. Soldiers were administered the ANAM, traditional neuropsychological tests, and a background questionnaire. Cases were enrolled within 72 h of concussion. Cases exhibited poorer performance than controls on all ANAM subtests, with significant differences on simple reaction time (SRT), procedural reaction time (PRT), code substitution, and matching to sample (p .001). Discriminant ability of scores on SRT and PRT subtests was 71, which improved to 76 when pre-deployment baseline scores were available. An exploratory clinical decision tool incorporating ANAM scores and symptoms improved discriminant ability to 81. Results provide initial validation of the ANAM for detecting acute effects of battlefield concussion. C1 [Kelly, Mark P.; Parish, Robert V.] Walter Reed Army Med Ctr, Dept Psychol, Washington, DC 20307 USA. [Coldren, Rodney L.] USA, Publ Hlth Command, Directorate Epidemiol & Dis Surveillance, Aberdeen Proving Ground, MD USA. [Dretsch, Michael N.] USA, Aeromed Res Lab, Warfighter & Hlth Div, Ft Rucker, AL USA. [Russell, Michael L.] USA, Med Command Headquarters, Behav Hlth Div, Ft Sam Houston, TX USA. RP Kelly, MP (reprint author), Walter Reed Natl Mil Med Ctr, Dept Psychol, Bldg 10,7th Floor,7NE, Bethesda, MD 20889 USA. EM mark.kelly1@us.army.mil FU U.S. Army Medical Research Acquisition Activity [W81XWIH-09-2-0057] FX This work was supported in part by the U.S. Army Medical Research Acquisition Activity, 820 Chandler Street, Fort Detrick, Maryland 21702- 5014, Project W81XWIH-09-2-0057. NR 65 TC 21 Z9 22 U1 1 U2 13 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 0887-6177 J9 ARCH CLIN NEUROPSYCH JI Arch. Clin. Neuropsychol. PD JUN PY 2012 VL 27 IS 4 BP 375 EP 388 DI 10.1093/arclin/acs036 PG 14 WC Psychology, Clinical; Psychology SC Psychology GA 944JX UT WOS:000304198300001 PM 22491730 ER PT J AU Rafuse, ES AF Rafuse, Ethan S. TI Defeating Lee: A History of the Second Corps, Army of the Potomac SO CIVIL WAR HISTORY LA English DT Book Review C1 [Rafuse, Ethan S.] USA, Command & Gen Staff Coll, Washington, DC USA. RP Rafuse, ES (reprint author), USA, Command & Gen Staff Coll, Washington, DC USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU KENT STATE UNIV PRESS PI KENT PA C/O JOURNALS DEPT, KENT, OH 44242 USA SN 0009-8078 J9 CIVIL WAR HIST JI Civil War Hist. PD JUN PY 2012 VL 58 IS 2 BP 277 EP 279 PG 3 WC History SC History GA 944PG UT WOS:000304215700012 ER PT J AU Convertino, VA Rickards, CA Ryan, KL AF Convertino, Victor A. Rickards, Caroline A. Ryan, Kathy L. TI Autonomic mechanisms associated with heart rate and vasoconstrictor reserves SO CLINICAL AUTONOMIC RESEARCH LA English DT Article DE Lower body negative pressure; Hemorrhage; Sympathetic nerve activity; Cardiac vagal control ID BODY NEGATIVE-PRESSURE; POSTSPACEFLIGHT ORTHOSTATIC HYPOTENSION; RELATIVE BRADYCARDIA; TRAUMA PATIENTS; BAROREFLEX RESPONSES; BARORECEPTOR REFLEX; CENTRAL HYPOVOLEMIA; CONSCIOUS RABBITS; RATE-VARIABILITY; BLOOD-VOLUME AB Hemorrhage is accompanied by baroreflex-mediated tachycardia and vasoconstriction. The difference between baseline and maximum responses is defined as the heart rate (HR) and vasoconstrictor 'reserve'. To test the hypothesis that higher HR and vasoconstrictor reserves in subjects with high tolerance (HT) to central hypovolemia is associated with greater reserve for sympathoexcitation and vagal withdrawal compared with low tolerant (LT) subjects. R-R intervals (RRI), systolic arterial pressure (SAP), estimated stroke volume, and muscle sympathetic nerve activity (MSNA) were measured during lower body negative pressure (LBNP) designed to induce pre-syncope. Subjects with tolerance a parts per thousand currency sign60 mmHg LBNP were classified as LT ( = 22) while subjects who tolerated LBNP levels > 60 mmHg were classified as HT ( = 56). Spontaneous cardiac baroreflex sensitivity (BRS) was assessed via RRI-SAP down-down sequences. HR reserve in HT subjects (+52 +/- A 2 bpm) was twofold greater ( < 0.001) than that in LT subjects (+27 +/- A 3 bpm). Vasoconstrictor reserve in the HT group (+3.4 +/- A 0.5 pru) was greater ( = 0.04) than that of the LT group (+1.9 +/- A 0.3 pru). HT subjects demonstrated greater ( a parts per thousand currency sign 0.03) BRS reserve (-14.2 +/- A 1.8 ms/mmHg) and MSNA reserve (+41 +/- A 2 bursts/min) compared with LT subjects (-7.4 +/- A 1.7 ms/mmHg and +26 +/- A 7 bursts/min). Our data support the hypothesis that greater physiological reserve capacity for tachycardia and vasoconstriction related to high tolerance to central hypovolemia is associated with greater reserves for sympathoexcitation and cardiac vagal withdrawal. C1 [Convertino, Victor A.; Ryan, Kathy L.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Rickards, Caroline A.] Univ Texas San Antonio, San Antonio, TX 78249 USA. RP Convertino, VA (reprint author), USA, Inst Surg Res, 3698 Chambers Pass, Ft Sam Houston, TX 78234 USA. EM victor.convertino@amedd.army.mil FU US Army FX We thank the experimental subjects for their cheerful cooperation, as well as Mr Gary Muniz for his superb technical assistance and Drs John McManus, Girish Sethuraman, Keith Berry, Steven Glorsky and Robert Gerhardt for their assistance with physical examinations and medical monitoring of the subjects. This research was supported by funding from the US Army Combat Casualty Care Research Program. The opinions or assertions contained herein are the private views of the author and are not to be construed as official or as reflecting the views of the US Department of the Army or the US Department of Defense. NR 48 TC 27 Z9 27 U1 0 U2 11 PU SPRINGER HEIDELBERG PI HEIDELBERG PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY SN 0959-9851 J9 CLIN AUTON RES JI Clin. Auton. Res. PD JUN PY 2012 VL 22 IS 3 BP 123 EP 130 DI 10.1007/s10286-011-0151-5 PG 8 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA 944BL UT WOS:000304173300002 PM 22083580 ER PT J AU Snapp, WB Janna, W AF Snapp, William B. Janna, William TI Sublimation of vertically oriented paradichlorobenzene cylinders in a natural convection environment SO HEAT AND MASS TRANSFER LA English DT Article ID HORIZONTAL PLATES; MASS-TRANSFER AB Paradichlorobenzene cylinders were cast, then suspended vertically and allowed to sublimate in air. Data on mass versus time were measured, and a sublimation rate was calculated. Three cylinders of different diameters were used: 1 inch (2.54 cm), 1.5 inch (3.81 cm), and 2 inch (5.08 cm). The length of all three cylinders was 10 in. (25.4 cm). Calculations indicate that the Schmidt number was constant. The Sherwood number ranged from 23 to 26, and Rayleigh numbers varied from 11 x 10(3) to 88 x 10(3). The objective of this study was to develop a correlation for determining the mass transfer coefficient of vertically suspended paradichlorobenzene cylinders in a natural convection environment. An equation relating Sherwood and Rayleigh numbers was derived. C1 [Janna, William] Univ Memphis, Memphis, TN 38152 USA. [Snapp, William B.] USA, Corps Engineers, Memphis, TN USA. RP Janna, W (reprint author), Univ Memphis, Memphis, TN 38152 USA. EM wsjanna@memphis.edu NR 9 TC 0 Z9 0 U1 1 U2 5 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0947-7411 J9 HEAT MASS TRANSFER JI Heat Mass Transf. PD JUN PY 2012 VL 48 IS 6 BP 1005 EP 1010 DI 10.1007/s00231-011-0952-z PG 6 WC Thermodynamics; Mechanics SC Thermodynamics; Mechanics GA 944CF UT WOS:000304175300013 ER PT J AU Saengjaruk, P Tantisiriwat, W Romputtan, P Chuenchitra, T AF Saengjaruk, Patcharin Tantisiriwat, Worapot Romputtan, Pornsuk Chuenchitra, Thippawan TI EXPRESSION OF IMMUNOLOGICAL MOLECULES ON THE ANTIGEN PRESENTING CELLS DURING CHRONIC VIRAL INFECTION SO INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY LA English DT Meeting Abstract C1 [Saengjaruk, Patcharin; Romputtan, Pornsuk] Srinakharinwirot Univ, Fac Med, Dept Pathol, Bangkok, Thailand. [Tantisiriwat, Worapot] Srinakharinwirot Univ, Fac Med, Dept Prevent Med, Bangkok, Thailand. [Chuenchitra, Thippawan] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1751-5521 J9 INT J LAB HEMATOL JI Int. J. Lab. Hematol. PD JUN PY 2012 VL 34 SU 1 SI SI BP 57 EP 57 PG 1 WC Hematology SC Hematology GA 942YH UT WOS:000304087100079 ER PT J AU Suedel, BC Lutz, CH Clarke, JU Clarke, DG AF Suedel, Burton C. Lutz, Charles H. Clarke, Joan U. Clarke, Douglas G. TI The effects of suspended sediment on walleye (Sander vitreus) eggs SO JOURNAL OF SOILS AND SEDIMENTS LA English DT Article DE Dredging; Environmental windows; Suspended sediment; Walleye (Sander vitreus) ID WESTERN LAKE-ERIE; LARVAL WALLEYE; COHO SALMON; STIZOSTEDION-VITREUM; TURBIDITY; FISH; BEHAVIOR; IMPACTS; SOLIDS; WATER AB Sediment resuspension is among the most widely cited concerns that lead to restricted dredging timeframes. Protection of fish species is a primary concern regarding the effects of dredging operations, yet experimental data establishing thresholds for uncontaminated suspended sediment effects are largely lacking. We conducted research to determine suspended sediment effects on walleye () egg hatching success and gross morphology following exposures mimicking sediment resuspension during dredging operations. Newly spawned eggs of northern and southern walleye strains were continuously exposed for 3 days to suspended sediment concentrations of 0, 100, 250, and 500 mg l(-1), using sediment from Maumee Bay, OH, USA. These concentrations spanned the range measured in the vicinity of dredging operations in the Western Basin of Lake Erie. Northern and southern strain egg hatching rates were 53% and 39% of exposed eggs and 82% and 74% of viable eggs exposed, which are within reported ranges for this species. Data indicated no statistically significant effects of suspended sediment on hatching success. Gross morphological observations of exposed fry yielded no evidence of detrimental effects. Experimental results indicated that walleye eggs are relatively tolerant to exposures likely to be encountered at dredging projects as performed in the Great Lakes region. Our results suggest that, given detailed knowledge of dredging project site-specific conditions and the mode of dredging to be used, better informed decisions can be made regarding adequate protective management practices. In many cases, flexibility could be given to the dredging contractor while maintaining a very low probability of risk to walleye spawning habitat. C1 [Suedel, Burton C.; Lutz, Charles H.; Clarke, Joan U.; Clarke, Douglas G.] USA, Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA. RP Suedel, BC (reprint author), USA, Engineer Res & Dev Ctr, Environm Lab, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM burton.suedel@usace.army.mil FU Dredging Operations and Environmental Research Program FX We gratefully thank Pat Howard of the Hebron State Fish Hatchery, OH, and Justin Wilkins of the North Mississippi Fish Hatchery and their staffs for their assistance in providing walleye eggs. We thank Roger Knight, Ohio Department of Natural Resources Division of Wildlife, for helpful insights prior to the study. We thank Scott Pickard of the Corps of Engineers Buffalo District, for coordination of sediment collection and experimental design insight and review of an earlier version of the paper; Cynthia Banks for her expert technical assistance and comments on an earlier draft; and Gary Ray for grain size analysis. This research was funded by the Dredging Operations and Environmental Research Program, Todd Bridges, Director. Permission was granted by the Chief of Engineers to publish this material. NR 40 TC 5 Z9 6 U1 2 U2 20 PU SPRINGER HEIDELBERG PI HEIDELBERG PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY SN 1439-0108 EI 1614-7480 J9 J SOIL SEDIMENT JI J. Soils Sediments PD JUN PY 2012 VL 12 IS 6 BP 995 EP 1003 DI 10.1007/s11368-012-0521-1 PG 9 WC Environmental Sciences; Soil Science SC Environmental Sciences & Ecology; Agriculture GA 943XP UT WOS:000304160900017 ER PT J AU Shah, PB Hung, HA AF Shah, P. B. Hung, H. A. TI Critical design issues for high-power GaN/AlGaN anti-serial Schottky varactor frequency triplers SO MICROELECTRONICS JOURNAL LA English DT Article DE Varactor; III-Nitrides; Microwave; HEMT; Multiplier; Gallium nitride ID FIELD-EFFECT TRANSISTORS; POLARIZATION; DIODES; GAN; HETEROSTRUCTURES AB In this paper the importance of a new design variable for high power anti-serial Schottky varactors, the aluminum composition of the AlGaN barrier layer, is demonstrated. AlGaN/GaN varactors containing either (1) a high-doped/low-doped GaN region or (2) just a low doped GaN region have been compared demonstrating that the selection of the device structure also depends on the amplitude of the input signal being tripled in frequency. Stronger susceptance modulation is exhibited in AlGaN/GaN ASVs made from Ga-face polar material compared to N-face polar material. Results indicate choosing the proper aluminum composition results in 27% conversion efficiency with an input signal of 5 GHz and over 7% conversion efficiency with an input signal of 60 GHz along with optimization trends. With input voltage amplitudes over 10 V an AlGaN/GaN structure with 15% Al provides greater conversion efficiency than one with 5% Al. Power absorbed in the varactor also increases as aluminum percent increases affecting reliability and power transfer. Results of a GaN ASV performing as a frequency tripler for fundamental frequencies up to 110 GHz indicate an advantage to using an AlGaN/GaN epi-structure over only a GaN epi-structure. Published by Elsevier Ltd. C1 [Shah, P. B.; Hung, H. A.] USA, Res Lab, Sensors & Electron Devices Directorate, RDRL SER E, Adelphi, MD 20783 USA. RP Shah, PB (reprint author), USA, Res Lab, Sensors & Electron Devices Directorate, RDRL SER E, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM pankaj.b.shah.civ@mail.mil NR 20 TC 1 Z9 1 U1 1 U2 10 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0026-2692 J9 MICROELECTRON J JI Microelectron. J. PD JUN PY 2012 VL 43 IS 6 BP 410 EP 415 DI 10.1016/j.mejo.2012.03.003 PG 6 WC Engineering, Electrical & Electronic; Nanoscience & Nanotechnology SC Engineering; Science & Technology - Other Topics GA 941OR UT WOS:000303973000011 ER PT J AU DeRosa, CA Furusato, B Shaheduzzaman, S Srikantan, V Wang, Z Chen, Y Siefert, M Ravindranath, L Young, D Nau, M Dobi, A Werner, T McLeod, DG Vahey, MT Sesterhenn, IA Srivastava, S Petrovics, G AF DeRosa, C. A. Furusato, B. Shaheduzzaman, S. Srikantan, V. Wang, Z. Chen, Y. Siefert, M. Ravindranath, L. Young, D. Nau, M. Dobi, A. Werner, T. McLeod, D. G. Vahey, M. T. Sesterhenn, I. A. Srivastava, S. Petrovics, G. TI Elevated osteonectin/SPARC expression in primary prostate cancer predicts metastatic progression SO PROSTATE CANCER AND PROSTATIC DISEASES LA English DT Article DE gene expression; osteonectin/SPARC; prognostic marker; metastasis ID MICROARRAY DATA; MOLECULAR ALTERATIONS; PATHWAY; SPARC; GENE; GROWTH; TUMOR AB BACKGROUND: The majority of prostate cancers (CaP) are detected in early stages with uncertain prognosis. Therefore, an intensive effort is underway to define early predictive markers of CaP with aggressive progression characteristics. METHODS: In order to define such prognostic markers, we performed comparative analyses of transcriptomes of well-and poorly differentiated (PD) tumor cells from primary tumors of patients (N = 40) with 78 months of mean follow-up after radical prostatectomy. Validation experiments were carried out at transcript level by quantitative real-time reverse transcriptase-PCR (RT-PCR) (N = 110) and at protein level by immunohistochemistry (N = 53) in primary tumors from an independent patient cohort. RESULTS: Association of a biochemical network of 12 genes with SPARC gene as a central node was highlighted with PD phenotype. Of note, there was remarkable enrichment of NKXH_NKXH_HOX composite regulatory elements in the promoter of the genes in this network suggesting a biological significance of this gene-expression regulatory mechanism in CaP progression. Further, quantitative expression analyses of SPARC mRNA in primary prostate tumor cells of 110 patients validated the association of SPARC expression with poor differentiation and higher Gleason score. Most significantly, higher SPARC protein expression at the time of prostatectomy was associated with the subsequent development of metastasis (P = 0.0006, AUC = 0.803). CONCLUSIONS: In summary, we propose that evaluation of SPARC in primary CaP has potential as a prognostic marker of metastatic progression. C1 [DeRosa, C. A.; Furusato, B.; Shaheduzzaman, S.; Srikantan, V.; Chen, Y.; Ravindranath, L.; Young, D.; Dobi, A.; McLeod, D. G.; Srivastava, S.; Petrovics, G.] Uniformed Serv Univ Hlth Sci, Dept Surg, Ctr Prostate Dis Res, Rockville, MD USA. [DeRosa, C. A.; McLeod, D. G.] Walter Reed Army Med Ctr, Urol Serv, Washington, DC 20307 USA. [Furusato, B.; Sesterhenn, I. A.] Armed Forces Inst Pathol, Dept Genitourinary Pathol, Washington, DC 20306 USA. [Wang, Z.; Nau, M.; Vahey, M. T.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Siefert, M.; Werner, T.] Genomatix GmbH, Munich, Germany. [Dobi, A.; McLeod, D. G.; Srivastava, S.] US Mil Canc Inst, Washington, DC USA. RP Petrovics, G (reprint author), Univ Hlth Sci, Uniformed Serv, Dept Surg, Ctr Prostate Dis Res, 1530 E Jefferson St, Rockville, MD 20852 USA. EM ssrivastava@cpdr.org; gpetrovics@cpdr.org OI Furusato, Bungo/0000-0003-4614-9882 FU National Institutes of Health [RO1-DK065977]; Center for Prostate Disease Research; Henry M. Jackson Foundation for the Advancement of Military Medicine (Rockville, MD); US Army Medical Research and Materiel Command FX This work was supported by grant RO1-DK065977 to SS and GP from the National Institutes of Health, and by the Center for Prostate Disease Research, a program of the Henry M. Jackson Foundation for the Advancement of Military Medicine (Rockville, MD), funded by the US Army Medical Research and Materiel Command. NR 38 TC 21 Z9 22 U1 0 U2 4 PU NATURE PUBLISHING GROUP PI LONDON PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND SN 1365-7852 J9 PROSTATE CANCER P D JI Prostate Cancer Prostatic Dis. PD JUN PY 2012 VL 15 IS 2 BP 150 EP 156 DI 10.1038/pcan.2011.61 PG 7 WC Oncology; Urology & Nephrology SC Oncology; Urology & Nephrology GA 942LA UT WOS:000304044300006 PM 22343836 ER PT J AU Ganesan, A Fieberg, A Agan, BK Lalani, T Landrum, ML Wortmann, G Crum-Cianflone, NF Lifson, AR Macalino, G AF Ganesan, Anuradha Fieberg, Ann Agan, Brian K. Lalani, Tahaniyat Landrum, Michael L. Wortmann, Glenn Crum-Cianflone, Nancy F. Lifson, Alan R. Macalino, Grace CA Infect Dis Clinical Res Program TI Results of a 25-Year Longitudinal Analysis of the Serologic Incidence of Syphilis in a Cohort of HIV-Infected Patients With Unrestricted Access to Care SO SEXUALLY TRANSMITTED DISEASES LA English DT Article ID ACTIVE ANTIRETROVIRAL THERAPY; SEXUALLY-TRANSMITTED-DISEASES; CRACK COCAINE USE; HOMOSEXUAL-MEN; UNITED-STATES; SECONDARY SYPHILIS; SAN-FRANCISCO; YOUNG-ADULTS; SEX; PREVALENCE AB Background: The well-described biologic and epidemiologic associations of syphilis and HIV are particularly relevant to the military, as service members are young and at risk for sexually transmitted infections. We therefore used the results of serial serologic testing to determine the prevalence, incidence, and risk factors for incident syphilis in a cohort of HIV-infected Department of Defense beneficiaries. Methods: Participants with a positive nontreponemal test at HIV diagnosis that was confirmed on treponemal testing were categorized as prevalent cases, and participants with an initial negative nontreponemal test who subsequently developed a confirmed positive nontreponemal test were categorized as incident cases. Results: At HIV diagnosis, the prevalence of syphilis was 5.8% (n = 202). A total of 4239 participants contributed 27,192 person-years (PY) to the incidence analysis and 347 (8%) developed syphilis (rate, 1.3/100 PY; [1.1, 1.4]). Syphilis incidence was highest during the calendar years 2006 to 2009 (2.5/100 PY; [2.0, 2.9]). In multivariate analyses, younger age (per 10 year increase hazard ratio [HR], 0.8; [0.8-0.9]), male gender (HR, 5.6; [2.3-13.7]), non-European-American ethnicity (African-American HR, 3.2; [2.5-4.2]; Hispanic HR, 1.9; [1.2-3.0]), and history of hepatitis B (HR, 1.5; [1.2-1.9]) or gonorrhea (HR, 1.4; [1.1-1.8]) were associated with syphilis. Conclusions: The significant burden of disease both at and after HIV diagnosis, observed in this cohort, suggests that the cost-effectiveness of extending syphilis screening to at-risk military members should be assessed. In addition, HIV-infected persons continue to acquire syphilis, emphasizing the continued importance of prevention for positive programs. C1 [Ganesan, Anuradha; Fieberg, Ann; Agan, Brian K.; Lalani, Tahaniyat; Landrum, Michael L.; Wortmann, Glenn; Crum-Cianflone, Nancy F.; Macalino, Grace] Uniformed Serv Univ Hlth Sci, Infect Dis Clin Res Program, Bethesda, MD 20814 USA. [Fieberg, Ann; Lifson, Alan R.] Univ Minnesota, Sch Publ Hlth, Minneapolis, MN USA. [Lalani, Tahaniyat; Landrum, Michael L.] San Antonio Mil Med Ctr, San Antonio, TX USA. [Wortmann, Glenn] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [Crum-Cianflone, Nancy F.] USN, San Diego Med Ctr, San Diego, CA 92152 USA. [Lalani, Tahaniyat] USN, Med Ctr Portsmouth, Portsmouth, VA USA. RP Ganesan, A (reprint author), Natl Naval Med Ctr, Div Infect Dis, 8901 Wisconsin Ave, Bethesda, MD 20889 USA. EM Anuradha.ganesan@med.navy.mil OI Eberly, Lynn/0000-0003-4763-330X; Agan, Brian/0000-0002-5114-1669 FU Department of Defense (DoD) through Uniformed Services University of the Health Sciences [IDCRP-000-26]; National Institute of Allergy and Infectious Diseases, National Institutes of Health (NIH) under Inter-Agency [Y1-AI-5072] FX Supported by the Infectious Disease Clinical Research Program (IDCRP) (IDCRP-000-26), a Department of Defense (DoD) program executed through the Uniformed Services University of the Health Sciences. This project has been funded in whole, or in part, with federal funds from the National Institute of Allergy and Infectious Diseases, National Institutes of Health (NIH), under Inter-Agency Agreement Y1-AI-5072. NR 36 TC 12 Z9 14 U1 2 U2 5 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0148-5717 J9 SEX TRANSM DIS JI Sex. Transm. Dis. PD JUN PY 2012 VL 39 IS 6 BP 440 EP 448 DI 10.1097/OLQ.0b013e318249d90f PG 9 WC Infectious Diseases SC Infectious Diseases GA 945CE UT WOS:000304249600008 PM 22592829 ER PT J AU Spaulding, AB Lifson, AR Iverson, ER Ganesan, A Landrum, ML Weintrob, AC Agan, BK Bavaro, MF O'Connell, RJ Macalino, GE AF Spaulding, Alicen B. Lifson, Alan R. Iverson, Erik R. Ganesan, Anuradha Landrum, Michael L. Weintrob, Amy C. Agan, Brian K. Bavaro, Mary F. O'Connell, Robert J. Macalino, Grace E. CA Infect Dis Clinical Res Program TI Gonorrhoea or chlamydia in a US military HIV-positive cohort SO SEXUALLY TRANSMITTED INFECTIONS LA English DT Article ID UNITED-STATES-ARMY; SEXUALLY-TRANSMITTED-DISEASES; IMMUNODEFICIENCY-VIRUS HIV; SAN-FRANCISCO; CARE; MEN; TRANSMISSION; PREVALENCE; INFECTION; PERSONNEL AB Objectives To investigate the epidemiology and risk factors of gonorrhoea (GC) or chlamydia (CT) coinfection in an HIV-positive US military cohort, focusing on the time after participants' knowledge of HIV diagnosis. Methods The authors analysed data from 4461 participants enrolled in the US Military Natural History Study cohort for GC or CT infection >= 6 months after their HIV-positive test. Results During a mean follow-up of 7.08 years, 482 (11%) participants acquired a GC or CT infection. Of these, 283 (6%) acquired a GC infection, 278 (6%) acquired a CT infection and 123 (3%) had multiple GC or CT infections during follow-up. Risk of GC or CT infection was significantly greater in those younger, male, African-American and with a history of GC or CT infection. Conclusions Frequent GC and CT diagnoses observed among members of this HIV-positive cohort indicate substantial ongoing risk behaviours that raise concerns for HIV transmission and underscore the need for continued screening to help identify and treat these sexually transmitted infections in this population. C1 [Spaulding, Alicen B.; Lifson, Alan R.; Iverson, Erik R.] Univ Minnesota, Sch Publ Hlth, Div Epidemiol & Community Hlth, Minneapolis, MN 55454 USA. [Spaulding, Alicen B.; Lifson, Alan R.; Iverson, Erik R.; Ganesan, Anuradha; Landrum, Michael L.; Weintrob, Amy C.; Agan, Brian K.; Bavaro, Mary F.; Macalino, Grace E.] Uniformed Serv Univ Hlth Sci, Infect Dis Clin Res Program, Bethesda, MD 20814 USA. [Ganesan, Anuradha; Weintrob, Amy C.] Walter Reed Natl Mil Med Ctr, Bethesda, MD USA. [Landrum, Michael L.] San Antonio Mil Hlth Syst, Ft Sam Houston, TX USA. [Bavaro, Mary F.] USN, Med Ctr, San Diego, CA 92152 USA. [O'Connell, Robert J.] Walter Reed Army Inst Res, Silver Spring, MD USA. RP Spaulding, AB (reprint author), Univ Minnesota, Sch Publ Hlth, Div Epidemiol & Community Hlth, 1300 S 2nd St,Suite 300, Minneapolis, MN 55454 USA. EM spau0016@umn.edu OI Agan, Brian/0000-0002-5114-1669; Polis, Michael/0000-0002-9151-2268 FU IDCRP HIV Working Group; National Institute of Allergy and Infectious Diseases, Bethesda, MD; M Polis, J Powers, E Tramont; Naval Medical Center, Portsmouth, VA; T Lalani, S Banks; Naval Medical Center, San Diego, CA; N Crum-Cianflone, H Chun, M Linfesty; Walter Reed National Military Medical Center, Bethesda, MD; C Decker, S Fraser, J Hartzell, R Rossner, P Waterman, G Wortmann, T Warkentien, T Whitman, M Zapor; San Antonio Military Medical Center, San Antonio, TX; J Okulicz, S Merritt; Tripler Army Medical Center, Honolulu, HI; G Hsue, A Johnson; University of Minnesota, Minneapolis, MN; L Eberly; Uniformed Services University of the Health Sciences, Bethesda, MD; M Kortepeter; Walter Reed Army Institute of Research, Silver Spring, MD; S Peel, C Eggleston; Walter Reed Army Medical Center, Washington, DC; Infectious Disease Clinical Research Program (IDCRP) [IDCRP-000-26]; Department of Defense through Uniformed Services University of the Health Sciences; National Institute of Allergy and Infectious Diseases, National Institutes of Health, under Inter-Agency Agreement [Y1-AI-5072] FX We especially would like to thank the participants of the HIV NHS for making this research possible and to acknowledge all military HIV researchers who have contributed to the success of the HIV NHS over time. Specifically we would like to acknowledge the many contributions of and support from members of the IDCRP HIV Working Group: National Institute of Allergy and Infectious Diseases, Bethesda, MD: M Polis, J Powers, E Tramont; Naval Medical Center, Portsmouth, VA: T Lalani, S Banks; Naval Medical Center, San Diego, CA: N Crum-Cianflone, H Chun, M Linfesty; Walter Reed National Military Medical Center, Bethesda, MD: C Decker, S Fraser, J Hartzell, R Rossner, P Waterman, G Wortmann, T Warkentien, T Whitman, M Zapor; San Antonio Military Medical Center, San Antonio, TX: J Okulicz, S Merritt; Tripler Army Medical Center, Honolulu, HI: G Hsue, A Johnson; University of Minnesota, Minneapolis, MN: L Eberly; Uniformed Services University of the Health Sciences, Bethesda, MD: M Kortepeter; Walter Reed Army Institute of Research, Silver Spring, MD: S Peel, C Eggleston; Walter Reed Army Medical Center, Washington, DC: S Fraser, J Hartzell, R Rossner, P Waterman, M Zapor, G Wortmann.; Support for this work (IDCRP-000-26) was provided by the Infectious Disease Clinical Research Program (IDCRP), a Department of Defense program executed through the Uniformed Services University of the Health Sciences. This project has been funded in whole, or in part, with federal funds from the National Institute of Allergy and Infectious Diseases, National Institutes of Health, under Inter-Agency Agreement Y1-AI-5072. The content of this publication is the sole responsibility of the authors and does not necessarily reflect the views or policies of the NIH or the Department of Health and Human Services, the DoD or the Departments of the Army, Navy or Air Force. Mention of trade names, commercial products, or organisations does not imply endorsement by the US Government. NR 31 TC 9 Z9 9 U1 0 U2 1 PU B M J PUBLISHING GROUP PI LONDON PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND SN 1368-4973 J9 SEX TRANSM INFECT JI Sex. Transm. Infect. PD JUN PY 2012 VL 88 IS 4 BP 266 EP 271 DI 10.1136/sextrans-2011-050173 PG 6 WC Infectious Diseases SC Infectious Diseases GA 941TS UT WOS:000303989600010 PM 22223813 ER PT J AU Chung, KK Ryan, KL Rickards, CA Hinojosa-Laborde, C Pamplin, JC Patel, SS Herold, TS Convertino, VA AF Chung, Kevin K. Ryan, Kathy L. Rickards, Caroline A. Hinojosa-Laborde, Carmen Pamplin, Jeremy C. Patel, Shimul S. Herold, Thomas S. Convertino, Victor A. TI PROGRESSIVE REDUCTION IN CENTRAL BLOOD VOLUME IS NOT DETECTED BY SUBLINGUAL CAPNOGRAPHY SO SHOCK LA English DT Article DE Shock; hypovolemia; monitoring; near-infrared spectroscopy; hemodynamics ID CRITICALLY-ILL PATIENTS; BODY NEGATIVE-PRESSURE; REGIONAL VASCULAR-RESPONSES; GASTRIC-MUCOSAL PH; HEMORRHAGIC-SHOCK; CENTRAL HYPOVOLEMIA; OXYGEN-SATURATION; EARLY INDICATOR; TRAUMA PATIENTS; SKELETAL-MUSCLE AB Early detection and management of shock are important in optimizing clinical outcomes. One regional marker, sublingual capnography (SLCO2), is particularly appealing as redistribution of blood flow away from the sublingual mucosa can happen very early in the compensatory phase of hypovolemic shock. Our objective was to test the hypothesis that SLCO2 would detect early hypovolemia in a human laboratory model of hemorrhage: progressive lower body negative pressure until onset of cardiovascular collapse. Eighteen healthy nonsmoking subjects (10 males, 8 females) with mean age of 28 (SD, 8) years, body weight of 72 (SD, 13) kg, and height of 172 (SD, 9) cm were recruited to participate, of whom 17 completed the experiment. Average time to presyncope was 1,579 +/- 72 s (mean +/- SE). At the time of cardiovascular collapse, lower body negative pressure altered (P < 0.001) systolic blood pressure (mean +/- SE: 130 +/- 3 vs. 98 +/- 2 mm Hg), pulse pressure (mean +/- SE: 58 +/- 2 vs. 33 +/- 2 mm Hg), and heart rate (mean +/- SE: 63 +/- 3 vs. 102 +/- 6 beats/min) when compared with baseline, whereas SLCO2 did not change (49.1 +/- 1.0 vs. 48.6 +/- 1.5 mm Hg, P = 0.624). In a model of progressive central hypovolemia in humans, we did not detect metabolic derangements in the sublingual mucosa as measured by SLCO2. C1 [Chung, Kevin K.; Ryan, Kathy L.; Hinojosa-Laborde, Carmen; Herold, Thomas S.; Convertino, Victor A.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Rickards, Caroline A.] Univ Texas San Antonio, Dept Hlth & Kinesiol, San Antonio, TX USA. [Pamplin, Jeremy C.; Patel, Shimul S.] San Antonio Mil Med Ctr, Ft Sam Houston, TX USA. RP Chung, KK (reprint author), USA, Inst Surg Res, 3638 Chambers Pass, Ft Sam Houston, TX 78234 USA. EM Kevin.chung@amedd.army.mil FU Advanced Capabilities for Emergency Medical Monitoring Task Area FX This study was funded by the Advanced Capabilities for Emergency Medical Monitoring Task Area. NR 43 TC 2 Z9 2 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1073-2322 J9 SHOCK JI Shock PD JUN PY 2012 VL 37 IS 6 BP 586 EP 591 DI 10.1097/SHK.0b013e318252da82 PG 6 WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System & Cardiology GA 944LD UT WOS:000304202200005 PM 22552018 ER PT J AU Martini, WZ Chung, KK Dubick, MA Blackbourne, LH AF Martini, Wenjun Z. Chung, Kevin K. Dubick, Michael A. Blackbourne, Lorne H. TI DAILY PROFILES OF FIBRINOGEN METABOLISM FOR 5 DAYS FOLLOWING HEMORRHAGE AND LACTATED RINGER'S RESUSCITATION IN PIGS SO SHOCK LA English DT Article DE Hemorrhagic shock; fibrinogen synthesis; fibrinogen breakdown; coagulation; stable isotopes; gas chromatograph mass spectrometry ID MASSIVE TRANSFUSION; PROTEIN-SYNTHESIS; INJURED PATIENTS; CLOTTING TIME; PLASMA; COAGULATION; COAGULOPATHY; SHOCK; THROMBELASTOGRAPHY; HYPOTHERMIA AB This study's objective was to investigate the daily dynamics of fibrinogen metabolism and coagulation function for 5 days after hemorrhagic shock in pigs. Sixteen pigs were randomized into the control (C) and the hemorrhage (H) groups. On day 1, hemorrhage was induced in H by bleeding 35% of the estimated total blood volume, followed by resuscitation with lactated Ringer's solution at three times the bled volume. Then, a primed constant infusion of stable isotopes was performed in both groups daily for 5 days to measure changes in fibrinogen metabolism, together with changes in hemodynamics and coagulation function. Hemorrhage caused a decrease in mean arterial pressure and an increase in heart rate. Fluid resuscitation corrected these changes. Compared with baseline day 1, fibrinogen levels in H were decreased to 76% +/- 6% by hemorrhage and resuscitation on day 1, increased to 217% +/- 16% on day 2, and remained elevated afterward; clot strength in H was decreased by hemorrhage on day 1 and returned to baseline values on day 2 and afterward. Compared with day 1 control value (1.3 +/- 0.1 mg/kg per hour), fibrinogen synthesis in H was increased to 3.6 +/- 0.1, 5.1 +/- 0.5, 2.6 +/- 0.4, 2.7 +/- 0.5, and 2.3 +/- 0.3 mg/kg per hour on days 1 through 5 (all P < 0.05); fibrinogen breakdown in H was elevated on days 1 and 2 but returned to control values afterward. Hemorrhage caused acute decreases in fibrinogen concentration and clot strength, followed by an increase in fibrinogen concentration and recovery of clot strength. The increase in fibrinogen appeared primarily due to a sustained increase in fibrinogen synthesis. C1 [Martini, Wenjun Z.; Chung, Kevin K.; Dubick, Michael A.; Blackbourne, Lorne H.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Martini, WZ (reprint author), USA, Inst Surg Res, 3698 Chambers Pass, Ft Sam Houston, TX 78234 USA. EM wenjun.martini@amedd.army.mil FU US Army Medical Research and Materiel Command FX This study was supported by the US Army Medical Research and Materiel Command. The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the US Department of the Army or the US Department of Defense. NR 33 TC 5 Z9 5 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1073-2322 J9 SHOCK JI Shock PD JUN PY 2012 VL 37 IS 6 BP 605 EP 610 DI 10.1097/SHK.0b013e3182522e2c PG 6 WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System & Cardiology GA 944LD UT WOS:000304202200008 PM 22552021 ER PT J AU Waterman, B Walker, JJ Swaims, C Shortt, M Todd, MS Machen, SM Owens, BD AF Waterman, Brian Walker, John J. Swaims, Chad Shortt, Michael Todd, Michael S. Machen, Shaun M. Owens, Brett D. TI The Efficacy of Combined Cryotherapy and Compression Compared with Cryotherapy Alone Following Anterior Cruciate Ligament Reconstruction SO JOURNAL OF KNEE SURGERY LA English DT Article DE cruciate; cryotherapy; cooling; ice; compression; knee AB While cryotherapy has been shown to decrease postoperative pain after anterior cruciate ligament (ACL) reconstruction, less is known of the effects of combined cryotherapy and compression. The goal of this study was to compare subjective and objective patient outcomes following ACL reconstruction with combined compression and cryotherapy compared with traditional ice therapy alone. Patients undergoing ACL reconstruction were randomized to cryotherapy/compression device (group 1) or a standardized ice pack (group 2). Both groups were instructed to use the ice or cryotherapy/compression device three times per day and return to the clinic at 1, 2, and 6 weeks postoperatively. Patient-derived outcome measurements used in this study consisted of the visual analog scale (VAS), the Lysholm knee score, Short Form-36 (SF-36), and single assessment numerical evaluation (SANE). Circumferential measurements of the knee at three locations (1 cm proximal to patella, mid-patella, and 1 cm distal to patella) were also obtained as a measure of postoperative edema. Narcotic medication use was recorded by questionnaire. The primary outcome measure (VAS) was significantly different among groups in the preoperative measurement, despite similarities in group demographics. Baseline VAS for group 1 was 54.9 compared with group 2 at 35.6 (p = 0.01). By 6 weeks, this had lowered to 28.1 and 40.3, respectively, resulting in a significant 27-point decrease in mean VAS for group 1 (p < 0.0001). However, the small increase in VAS for group 2 was not significant (p = 0.34). No significant differences were noted for the Lysholm, SF-36, or SANE scores either between groups or time points. Furthermore, no significant differences were noted for any of the circumferential measurements either between groups or time points. Of all patients, 83% of group 1 discontinued narcotic use by 6 weeks, compared with only 28% of group 2 (p = 0.0008). The use of combined cryotherapy and compression in the postoperative period after ACL reconstruction results in improved, short-term pain relief and a greater likelihood of independence from narcotic use compared with cryotherapy alone. C1 [Waterman, Brian; Walker, John J.; Swaims, Chad; Shortt, Michael; Todd, Michael S.; Machen, Shaun M.] William Beaumont Army Med Ctr, Dept Orthopaed, El Paso, TX 79920 USA. [Owens, Brett D.] Keller Army Hosp, West Point, NY 10996 USA. RP Owens, BD (reprint author), Keller Army Hosp, 900 Washington Rd, West Point, NY 10996 USA. EM b.owens@us.army.mil NR 31 TC 13 Z9 13 U1 1 U2 11 PU GEORG THIEME VERLAG KG PI STUTTGART PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY SN 1538-8506 EI 1938-2480 J9 J KNEE SURG JI J. Knee Surg. PD JUN PY 2012 VL 25 IS 2 BP 155 EP 160 DI 10.1055/s-0031-1299650 PG 6 WC Orthopedics SC Orthopedics GA V35SE UT WOS:000209167700009 PM 22928433 ER PT J AU Forney, AJ AF Forney, Andrew J. TI POLITICS, LABOR, AND THE WAR ON BIG BUSINESS: The Path of Reform in Arizona, 1890-1920 SO JOURNAL OF THE WEST LA English DT Book Review C1 [Forney, Andrew J.] US Mil Acad, Dept Hist, West Point, NY 10996 USA. RP Forney, AJ (reprint author), US Mil Acad, Dept Hist, West Point, NY 10996 USA. NR 1 TC 0 Z9 0 U1 0 U2 1 PU ABC-CLIO PI SANTA BARBARA PA 130 CREMONA DR, SANTA BARBARA, CA 93117 USA SN 0022-5169 EI 1930-0115 J9 J WEST JI J. West PD SUM PY 2012 VL 51 IS 3 BP 102 EP 102 PG 1 WC History SC History GA V31LQ UT WOS:000208885500017 ER PT J AU Zamora, DO Natesan, S Christy, RJ AF Zamora, David O. Natesan, Shanmugasundaram Christy, Robert J. TI Constructing a Collagen Hydrogel for the Delivery of Stem Cell-loaded Chitosan Microspheres SO JOVE-JOURNAL OF VISUALIZED EXPERIMENTS LA English DT Article DE Bioengineering; Issue 64; Biomedical Engineering; Tissue Engineering; chitosan; microspheres; collagen; hydrogel; cell delivery; adipose-derived stem cells; ASC; CSM AB Multipotent stem cells have been shown to be extremely useful in the field of regenerative medicine(1-3). However, in order to use these cells effectively for tissue regeneration, a number of variables must be taken into account. These variables include: the total volume and surface area of the implantation site, the mechanical properties of the tissue and the tissue microenvironment, which includes the amount of vascularization and the components of the extracellular matrix. Therefore, the materials being used to deliver these cells must be biocompatible with a defined chemical composition while maintaining a mechanical strength that mimics the host tissue. These materials must also be permeable to oxygen and nutrients to provide a favorable microenvironment for cells to attach and proliferate. Chitosan, a cationic polysaccharide with excellent biocompatibility, can be easily chemically modified and has a high affinity to bind with in vivo macromolecules(4-5). Chitosan mimics the glycosaminoglycan portion of the extracellular matrix, enabling it to function as a substrate for cell adhesion, migration and proliferation. In this study we utilize chitosan in the form of microspheres to deliver adipose-derived stem cells (ASC) into a collagen based three-dimensional scaffold(6). An ideal cell-to-microsphere ratio was determined with respect to incubation time and cell density to achieve maximum number of cells that could be loaded. Once ASC are seeded onto the chitosan microspheres (CSM), they are embedded in a collagen scaffold and can be maintained in culture for extended periods. In summary, this study provides a method to precisely deliver stem cells within a three dimensional biomaterial scaffold. C1 [Zamora, David O.; Natesan, Shanmugasundaram; Christy, Robert J.] US Army Inst Surg Res, Dept Regenerat Med, Ft Sam Houston, TX 78234 USA. RP Christy, RJ (reprint author), US Army Inst Surg Res, Dept Regenerat Med, Ft Sam Houston, TX 78234 USA. EM Robert.Christy@us.army.mil OI Zamora, David/0000-0002-7003-5933; Natesan, Shanmugasundaram/0000-0003-4213-3111 FU Geneva Foundation; Pittsburgh Tissue Engineering Initiative FX D.O.Z. is supported by a grant awarded from The Geneva Foundation. S.N. was supported by a Postdoctoral Fellowship Grant from the Pittsburgh Tissue Engineering Initiative. NR 25 TC 0 Z9 0 U1 2 U2 12 PU JOURNAL OF VISUALIZED EXPERIMENTS PI CAMBRIDGE PA 1 ALEWIFE CENTER, STE 200, CAMBRIDGE, MA 02140 USA SN 1940-087X J9 JOVE-J VIS EXP JI J. Vis. Exp. PD JUN PY 2012 IS 64 AR UNSP e3624 DI 10.3791/3624 PG 7 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA V36PI UT WOS:000209223100006 PM 22688576 ER PT J AU Hjelkrem, M Morales, A Williams, CD Harrison, SA AF Hjelkrem, M. Morales, A. Williams, C. D. Harrison, S. A. TI Unconjugated hyperbilirubinemia is inversely associated with non-alcoholic steatohepatitis (NASH) SO ALIMENTARY PHARMACOLOGY & THERAPEUTICS LA English DT Article ID FATTY LIVER-DISEASE; SERUM URIC-ACID; GILBERT-SYNDROME; BILIRUBIN LEVELS; ANTIOXIDANT STATUS; COLORECTAL-CANCER; NAD(P)H OXIDASE; COLON-CANCER; RISK; POPULATION AB Background It has been recognised that unconjugated bilirubin contains hepatic anti-fibrogenic and anti-inflammatory properties and is a potent physiological antioxidant cytoprotectant. We believe that unconjugated hyperbilirubinemia may protect against development of non-alcoholic steatohepatitis (NASH). Aim This study was conducted to assess the association of serum unconjugated bilirubin levels and histological liver damage in non-alcoholic fatty liver disease (NAFLD). Methods This was a retrospective analysis involving adult patients from a tertiary medical centre undergoing liver biopsy to evaluate suspected NAFLD or NASH and a control group without NAFLD based on normal liver ultrasound, labs and history. Identification of unconjugated hyperbilirubinemia was based on the presence of predominantly unconjugated bilirubin >= 1.0 mg/dL (17.1 mu mol/L) while fasting, in the absence of haemolytic disease or other hepatic function alteration. Results Six-hundred and forty-one patients were included. Unconjugated hyperbilirubinemia was inversely associated with NASH (OR 16.1, 95% CI 3.770.8 P < 0.001). Of the patients without NAFLD (133 patients), 13 (9.8%) had unconjugated hyperbilirubinemia (range 1.01.8, mean 1.4). Of the patients with NAFLD without NASH (285 patients), 32 (11.2%) had unconjugated hyperbilirubinemia (range 1.03.0, mean 1.4). Of the patients with NASH (223 patients), three (1.3%) had unconjugated hyperbilirubinemia (1.0, 1.1, 1.4). Conclusions Unconjugated hyperbilirubinemia is inversely associated with the histopathological severity of liver damage in non-alcoholic fatty liver disease. C1 [Harrison, S. A.] Brooke Army Med Ctr, Dept Med, Div Gastroenterol & Hepatol, Serv Hepatol, Ft Sam Houston, TX 78234 USA. [Hjelkrem, M.; Williams, C. D.] Brooke Army Med Ctr, Gastroenterol Serv, Ft Sam Houston, TX 78234 USA. [Morales, A.] Brooke Army Med Ctr, Internal Med Serv, Ft Sam Houston, TX 78234 USA. RP Harrison, SA (reprint author), Brooke Army Med Ctr, Dept Med, Div Gastroenterol & Hepatol, Serv Hepatol, Ft Sam Houston, TX 78234 USA. EM stephen.harrison@amedd.army.mil FU Rottapharm; Mochida Pharmaceuticals FX Stephen A. Harrison has served as an ad hoc advisory board member for Amylin Pharmaceuticals and has received research funding from Rottapharm and Mochida Pharmaceuticals. NR 48 TC 12 Z9 12 U1 1 U2 4 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0269-2813 J9 ALIMENT PHARM THER JI Aliment. Pharmacol. Ther. PD JUN PY 2012 VL 35 IS 12 BP 1416 EP 1423 DI 10.1111/j.1365-2036.2012.05114.x PG 8 WC Gastroenterology & Hepatology; Pharmacology & Pharmacy SC Gastroenterology & Hepatology; Pharmacology & Pharmacy GA 941QX UT WOS:000303978800007 PM 22540836 ER PT J AU Vandock, KP Mitchell, MJ Fioravanti, CF AF Vandock, Kurt P. Mitchell, Martin J. Fioravanti, Carmen F. TI EFFECTS OF PLANT FLAVONOIDS ON Manduca sexta (TOBACCO HORNWORM) FIFTH LARVAL INSTAR MIDGUT AND FAT BODY MITOCHONDRIAL TRANSHYDROGENASE SO ARCHIVES OF INSECT BIOCHEMISTRY AND PHYSIOLOGY LA English DT Article DE Manduca sexta fifth larval instar; midgut and fat body mitochondria; transhydrogenase; NADH and succinate dehydrogenase; plant flavonoids ID ECDYSONE 20-MONOOXYGENASE ACTIVITY; DEPENDENT STEROID HYDROXYLASE; ADULT HYMENOLEPIS-DIMINUTA; WANDERING STAGE LARVAE; PUPAL DEVELOPMENT; INSECT; LOCALIZATION; LEPIDOPTERA; SPHINGIDAE; SYSTEMS AB The reversible, membrane-associated transhydrogenase that catalyzes hydride-ion transfer between NADP(H) and NAD(H) was evaluated and compared to the corresponding NADH oxidase and succinate dehydrogenase activities in midgut and fat body mitochondria from fifth larval instar Manduca sexta. The developmentally significant NADPH-forming transhydrogenation occurs as a nonenergy- or energy-linked activity with energy for the latter derived from either electron transport-dependent NADH or succinate utilization, or ATP hydrolysis by Mg++-dependent ATPase. In general, the plant flavonoids examined (chyrsin, juglone, morine, quercetin, and myricetin) affected all reactions in a dose-dependent fashion. Differences in the responses to the flavonoids were apparent, with the most notable being inhibition of midgut, but stimulation of fat body transhydrogenase by morin, and myricetin as also noted for NADH oxidase and succinate dehydrogenase. Although quercetin inhibited or stimulated transhydrogenase activity depending on the origin of mitochondria, it was without effect on either midgut or fat body NADH oxidase or succinate dehydrogenase. Observed sonication-dependent increases in flavonoid inhibition may well reflect an alteration in membrane configuration, resulting in increased exposure of the enzyme systems to the flavonoids. The effects of flavonoids on the transhydrogenation, NADH oxidase, and succinate dehydrogenase reactions suggest that compounds of this nature may prove valuable in the control of insect populations by affecting these mitochondrial enzyme components. C1 [Vandock, Kurt P.] Houghton Coll, Dept Biol, Houghton, NY 14744 USA. [Vandock, Kurt P.] US Army Reserve, Army Reserve Med Command APMC, Forest Pk, GA 30297 USA. [Mitchell, Martin J.] Edinboro Univ Penn, Dept Biol & Hlth Serv, Edinboro, PA USA. [Fioravanti, Carmen F.] Bowling Green State Univ, Dept Biol Sci, Bowling Green, OH 43403 USA. RP Vandock, KP (reprint author), Houghton Coll, Dept Biol, 1 Willard Ave, Houghton, NY 14744 USA. EM kurt.vandock@houghton.edu FU National Institutes of Health [AI-15597]; United States Public Health Service; Edinboro University of Pennsylvania; United States Army Reserve, APMC FX Grant sponsor: National Institutes of Health; Grant number: AI-15597 (to C.F.F.); Grant sponsor: United States Public Health Service; Grant sponsor: Edinboro University of Pennsylvania (to M.J.M.); Grant sponsor: United States Army Reserve, APMC (to K.P.V.). NR 29 TC 6 Z9 6 U1 2 U2 8 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0739-4462 J9 ARCH INSECT BIOCHEM JI Arch. Insect Biochem. Physiol. PD JUN PY 2012 VL 80 IS 1 BP 15 EP 25 DI 10.1002/arch.21022 PG 11 WC Biochemistry & Molecular Biology; Entomology; Physiology SC Biochemistry & Molecular Biology; Entomology; Physiology GA 939XV UT WOS:000303855100002 PM 22522595 ER PT J AU Mace, JE Park, MS Mora, AG Chung, KK Martini, W White, CE Holcomb, JB Merrill, GA Dubick, MA Wolf, SE Wade, CE Schwacha, MG AF Mace, James E. Park, Myung S. Mora, Alejandra G. Chung, Kevin K. Martini, Wenjun White, Christopher E. Holcomb, John B. Merrill, Gerald A. Dubick, Michael A. Wolf, Steven E. Wade, Charles E. Schwacha, Martin G. TI Differential expression of the immunoinflammatory response in trauma patients: Burn vs. non-burn SO BURNS LA English DT Article DE Burn; Trauma; Cytokine; Inflammation; Interleukin-6; Interleukin-8; Multiple ID MULTIPLE INJURIES; THERMAL-INJURY; INFLAMMATORY RESPONSE; CIRCULATING LEVELS; PLASMA CYTOKINES; ORGAN FAILURE; ACUTE-PHASE; 2ND HIT; INTERLEUKIN-6; SIZE AB Rationale: Cytokines are central mediators of the immune-inflammatory response to injury and subsequent multiple organ dysfunction syndrome (MODS). Although previous studies evaluated cytokine levels after trauma, differences between patients with burn and non-burn trauma have not been assessed systematically. Methods: A prospective database of trauma patients admitted between May 2004 and September 2007 to the burn or surgical intensive care units within 24 h of injury with an anticipated stay of at least 72 h was analyzed. Sequential clinical and laboratory parameters were collected in the first week, including multiplex analysis data for plasma levels of inflammatory cytokines (IL-6, and IL-8). Patients with known pre-injury coagulopathy were excluded. A Marshall score of 10 or greater was defined as MODS. Results: A total of 179 patients were enrolled (67 burn and 112 non-burn). Plasma IL-6 and IL-8 levels were markedly elevated in both burn and non-burn patients compared to healthy volunteers. Burn subjects had higher levels of IL-6 and IL-8 than the non-burn on days through 7 after injury. Subjects with burns and at least 30% total body surface area were older and had a lower injury severity score, a higher prevalence of MODS, and correspondingly higher mortality. Multivariate analysis of injury type, MODS, and time did not demonstrate an influence of MODS. Conclusions: Burns were associated with a greater and more sustained immune-inflammatory response than non-burn trauma as evidenced by elevated plasma IL-6 and IL-8 levels during the first week. There was no association between MODS and plasma cytokine levels. Published by Elsevier Ltd and ISBI C1 [Mace, James E.; Mora, Alejandra G.; Chung, Kevin K.; Martini, Wenjun; White, Christopher E.; Dubick, Michael A.; Wolf, Steven E.; Schwacha, Martin G.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Park, Myung S.] Mayo Clin, Div Trauma Crit Care & Gen Surg, Rochester, MN 55905 USA. [Holcomb, John B.; Wade, Charles E.] Univ Texas Hlth Sci Ctr, Dept Surg, Houston, TX 77030 USA. [Merrill, Gerald A.] Brooke Army Med Ctr, Dept Clin Invest, Ft Sam Houston, TX 78234 USA. [Wolf, Steven E.; Schwacha, Martin G.] Univ Texas Hlth Sci Ctr San Antonio, Dept Surg, San Antonio, TX 78229 USA. RP Chung, KK (reprint author), USA, Inst Surg Res, 3400 Rawley E Chambers Dr, Ft Sam Houston, TX 78234 USA. EM kevin.chung@us.army.mil OI Wolf, Steven/0000-0003-2972-3440 NR 33 TC 15 Z9 18 U1 0 U2 2 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0305-4179 J9 BURNS JI Burns PD JUN PY 2012 VL 38 IS 4 BP 599 EP 606 DI 10.1016/j.burns.2011.10.013 PG 8 WC Critical Care Medicine; Dermatology; Surgery SC General & Internal Medicine; Dermatology; Surgery GA 937VQ UT WOS:000303691500020 PM 22103986 ER PT J AU Yost, TL AF Yost, Terri L. TI Nursing Care of Service Members With Head Injury During the Vietnam War SO JOURNAL OF NEUROSCIENCE NURSING LA English DT Article ID WOUNDS AB The purpose of this article was to describe and analyze the nursing management of head-injured soldiers by military nurses serving in the Vietnam War. This study used traditional historical methods and a military history framework. Primary sources included original military reports, letters, and policies from the Vietnam War period (located in the archives of the Army Medical Department, Office of Medical History in Falls Church, VA); journal articles of the time period; and autobiographical texts. Secondary sources consisted of biographical and historical texts and Web sites of historical societies. Findings supported that advances in medicine, nursing, and technology throughout the 1960s have an overall positive impact on patient care in a combat zone. The Vietnam War was a time when new theories in the management of head injuries led directly to overall improvements in survival. In conclusion, nurses were professionally and emotionally challenged on a near daily basis but were able to directly apply new nursing science in a combat environment to help improve survivability for those who may not have previously survived off the battlefield. C1 Tripler Army Med Ctr, Ctr Nursing Sci & Clin Inquiry, Honolulu, HI 96859 USA. RP Yost, TL (reprint author), Tripler Army Med Ctr, Ctr Nursing Sci & Clin Inquiry, Honolulu, HI 96859 USA. EM terri.yost@us.army.mil FU Uniformed Services University of the Health Sciences FX This project was sponsored by the TriService Nursing Research Program, Uniformed Services University of the Health Sciences; however, the information or content and conclusions do not necessarily represent the official position or policy of, nor should any official endorsement be inferred by, the TriService Nursing Research Program, the Uniformed Services University of the Health Sciences, the Department of Defense, or the U. S. Government. NR 20 TC 1 Z9 1 U1 0 U2 5 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0888-0395 J9 J NEUROSCI NURS JI J. Neurosci. Nurs. PD JUN PY 2012 VL 44 IS 3 BP 157 EP 163 DI 10.1097/JNN.0b013e31825106ba PG 7 WC Clinical Neurology; Nursing SC Neurosciences & Neurology; Nursing GA 937QZ UT WOS:000303674600007 PM 22555353 ER PT J AU Fry, LW Hannah, ST Noel, M Walumbwa, FO AF Fry, Louis W. Hannah, Sean T. Noel, Michael Walumbwa, Fred O. TI Impact of spiritual leadership on unit performance (vol 22, pg 259, 2011) SO LEADERSHIP QUARTERLY LA English DT Correction C1 [Fry, Louis W.] Texas A&M Cent Texas, Killeen, TX 76549 USA. [Hannah, Sean T.] US Mil Acad, Ctr Army Profess & Eth, West Point, NY 10996 USA. [Noel, Michael] US Mil Acad, Dept Behav Sci & Leadership, West Point, NY 10996 USA. [Walumbwa, Fred O.] Arizona State Univ, Dept Management, WP Carey Sch Business, Tempe, AZ 85287 USA. RP Fry, LW (reprint author), Texas A&M Cent Texas, 1901 S Clear Creek Rd, Killeen, TX 76549 USA. EM lwfry@ct.tamus.edu NR 1 TC 1 Z9 1 U1 2 U2 20 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1048-9843 J9 LEADERSHIP QUART JI Leadersh. Q. PD JUN PY 2012 VL 23 IS 3 BP 641 EP 641 DI 10.1016/j.leaqua.2012.04.001 PG 1 WC Psychology, Applied; Management SC Psychology; Business & Economics GA 939EB UT WOS:000303789100025 ER PT J AU Thomsen, M Brownell, K Groshek, M Kirsch, E AF Thomsen, Meredith Brownell, Kurt Groshek, Matthew Kirsch, Eileen TI Control of Reed Canarygrass Promotes Wetland Herb and Tree Seedling Establishment in an Upper Mississippi River Floodplain Forest SO WETLANDS LA English DT Article DE Floodplain forest; Restoration; Invasion; Reed canarygrass; Pre-emergent herbicides ID PHALARIS-ARUNDINACEA L.; MEADOW RESTORATIONS; INVASIVE GRASS; WET MEADOWS; VEGETATION; DISTURBANCE; PLANTS; SEDGE; DEER; DYNAMICS AB Phalaris arundinacea (reed canarygrass) is recognized as a problematic invader of North American marshes, decreasing biodiversity and persisting in the face of control efforts. Less is known about its ecology or management in forested wetlands, providing an opportunity to apply information about factors critical to an invader's control in one wetland type to another. In a potted plant experiment and in the field, we documented strong competitive effects of reed canarygrass on the establishment and early growth of tree seedlings. In the field, we demonstrated the effectiveness of a novel restoration strategy, combining site scarification with late fall applications of pre-emergent herbicides. Treatments delayed reed canarygrass emergence the following spring, creating a window of opportunity for the early growth of native plants in the absence of competition from the grass. They also allowed for follow-up herbicide treatments during the growing season. We documented greater establishment of wetland herbs and tree seedlings in treated areas. Data from small exclosures suggest, however, that deer browsing can limit tree seedling height growth in floodplain restorations. Slower tree growth will delay canopy closure, potentially allowing reed canarygrass re-invasion. Thus, it may be necessary to protect tree seedlings from herbivory to assure forest regeneration. C1 [Thomsen, Meredith] Univ Wisconsin, Dept Biol, La Crosse, WI 54601 USA. [Thomsen, Meredith] Univ Wisconsin, River Studies Ctr, La Crosse, WI 54601 USA. [Brownell, Kurt] USA, La Crescent Field Off, Corps Engineers, La Crescent, MN 55947 USA. [Groshek, Matthew] USA, Waukesha Field Off, Corps Engineers, Waukesha, WI 53186 USA. [Kirsch, Eileen] US Geol Survey, Upper Midwest Environm Sci Ctr, La Crosse, WI 54603 USA. RP Thomsen, M (reprint author), Univ Wisconsin, Dept Biol, 1725 State St, La Crosse, WI 54601 USA. EM mthomsen@uwlax.edu FU UW-L Faculty; College of Science and Health; United States Geologic Survey Upper Midwest Environmental Sciences Center FX This work was supported by a UW-L Faculty Research Grant, an Undergraduate Research Grant, and a College of Science and Health Dean's Research Fellowship. The United States Geologic Survey Upper Midwest Environmental Sciences Center provided funding for field assistants. DuPont and BASF Corporation donated the Oust (R) and Pendulum (R) herbicides used in the study. The authors thank the Environmental Stewardship staff at the La Crescent Field Office of the United States Army Corps of Engineers, St. Paul District for help in the field and site treatment expenses, Lee Shambeau for assistance with revisions, and the reviewers of our manuscript for their thoughtful comments. Any use of trade names or products does not imply endorsement by the United States Government. NR 44 TC 8 Z9 8 U1 3 U2 49 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0277-5212 J9 WETLANDS JI Wetlands PD JUN PY 2012 VL 32 IS 3 BP 543 EP 555 DI 10.1007/s13157-012-0289-5 PG 13 WC Ecology; Environmental Sciences SC Environmental Sciences & Ecology GA 940IV UT WOS:000303884100013 ER PT J AU Song, MC Sankar, BV Subhash, G Yen, CF AF Song, M. C. Sankar, B. V. Subhash, G. Yen, C. F. TI Analysis of mode I delamination of z-pinned composites using a non-dimensional analytical model SO COMPOSITES PART B-ENGINEERING LA English DT Article DE 3-Dimensional reinforcement; Delamination; Analytical modeling; Finite element analysis (FEA); z-Pinning ID RELEASE RATE; FRACTURE; PINS AB We present a non-dimensional analytical model for crack propagation in a z-pinned double cantilever beam specimen (DCB) under mode I loading. Effect of various design parameters on the crack bridging length and apparent fracture toughness are investigated using this model. The efficacy of the analytical model is evaluated by comparing the results with 3D finite element (FE) simulations of the DCB. In the FE model the z-pins are modeled as discrete nonlinear elements. Bi-linear cohesive elements are used ahead of the crack tip to account for the interlaminar fracture toughness of the composite material. The results for load-deflection and crack length obtained from the analytical model and the FE model are compared and found to be in good agreement. The proposed non-dimensional analytical model will be useful in the design and analysis of translaminar reinforcements for composite structures. (C) 2012 Elsevier Ltd. All rights reserved. C1 [Song, M. C.; Sankar, B. V.; Subhash, G.] Univ Florida, Dept Mech & Aerosp Engn, Gainesville, FL 32611 USA. [Yen, C. F.] USA, Ballist Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Sankar, BV (reprint author), Univ Florida, Dept Mech & Aerosp Engn, Gainesville, FL 32611 USA. EM sankar@ufl.edu OI Sankar, Bhavani/0000-0002-4556-1982 FU United States Army Research Office [W911NF-08-1-0120]; United States Army Research Laboratory FX The funding for this work was provided by the United States Army Research Office(Grant No. W911NF-08-1-0120) and the United States Army Research Laboratory. The authors also would like to thank Dr. James G. Ratcliff at the National Institute for Aerospace, Hampton, VA for the discussion of results. NR 18 TC 8 Z9 9 U1 1 U2 9 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1359-8368 J9 COMPOS PART B-ENG JI Compos. Pt. B-Eng. PD JUN PY 2012 VL 43 IS 4 BP 1776 EP 1784 DI 10.1016/j.compositesb.2012.01.086 PG 9 WC Engineering, Multidisciplinary; Materials Science, Composites SC Engineering; Materials Science GA 932KW UT WOS:000303291000014 ER PT J AU Jin, X Sarkar, S Ray, A Gupta, S Damarla, T AF Jin, Xin Sarkar, Soumalya Ray, Asok Gupta, Shalabh Damarla, Thyagaraju TI Target Detection and Classification Using Seismic and PIR Sensors SO IEEE SENSORS JOURNAL LA English DT Article DE Feature extraction; passive infrared sensor; seismic sensor; symbolic dynamic filtering; target detection and classification ID TRACKING; SYSTEMS AB Unattended ground sensors (UGS) are widely used to monitor human activities, such as pedestrian motion and detection of intruders in a secure region. Efficacy of UGS systems is often limited by high false alarm rates, possibly due to inadequacies of the underlying algorithms and limitations of onboard computation. In this regard, this paper presents a wavelet-based method for target detection and classification. The proposed method has been validated on data sets of seismic and passive infrared sensors for target detection and classification, as well as for payload and movement type identification of the targets. The proposed method has the advantages of fast execution time and low memory requirements and is potentially well-suited for real-time implementation with onboard UGS systems. C1 [Jin, Xin; Sarkar, Soumalya; Ray, Asok] Penn State Univ, Dept Mech Engn, University Pk, PA 16802 USA. [Gupta, Shalabh] Univ Connecticut, Dept Elect & Comp Engn, Storrs, CT 06269 USA. [Damarla, Thyagaraju] USA, Res Lab, Adelphi, MD 20783 USA. RP Jin, X (reprint author), Penn State Univ, Dept Mech Engn, University Pk, PA 16802 USA. EM xinjin@psu.edu; svs5464@psu.edu; axr2@psu.edu; shalabh.gupta@engr.uconn.edu; thyagaraju.damarla@us.army.mil RI Jin, Xin/H-5022-2012 FU U.S. Army Research Laboratory; U.S. Army Research Office [W911NF-07-1-0376] FX This work was supported in part by the U.S. Army Research Laboratory and the U.S. Army Research Office under Grant W911NF-07-1-0376. Any opinions, findings and conclusions or recommendations expressed in this publication are those of the authors and do not necessarily reflect the views of the sponsoring agencies. The associate editor coordinating the review of this paper and approving it for publication was Prof. Ralph Etienne-Cummings. NR 18 TC 32 Z9 32 U1 0 U2 24 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1530-437X J9 IEEE SENS J JI IEEE Sens. J. PD JUN PY 2012 VL 12 IS 6 BP 1709 EP 1718 DI 10.1109/JSEN.2011.2177257 PG 10 WC Engineering, Electrical & Electronic; Instruments & Instrumentation; Physics, Applied SC Engineering; Instruments & Instrumentation; Physics GA 933XN UT WOS:000303400000011 ER PT J AU Foley, DH Klein, TA Kim, HC Kim, MS Wilkerson, RC Harrison, G Rueda, LM Lee, WJ AF Foley, Desmond H. Klein, Terry A. Kim, Heung Chul Kim, Myung-Soon Wilkerson, Richard C. Harrison, Genelle Rueda, Leopoldo M. Lee, Won-Ja TI Synchronous peaks in trap catches of malaria-infected mosquito species at Daeseongdong, a border village between North and South Korea SO JOURNAL OF VECTOR ECOLOGY LA English DT Article DE Anopheles sinensis; Plasmodium vivax; sporozoite; Korea; Demilitarized Zone; extrinsic incubation period ID REPUBLIC-OF-KOREA; PLASMODIUM-VIVAX MALARIA; SURVEILLANCE AB Malaria continues to be a major health threat near the Demilitarized Zone (DMZ) that separates North and South Korea. Adult mosquitoes were collected from 20 July through 21 October, 2010 at Daeseongdong, a small village within the DMZ. Molecular techniques were used to identify Anopheles to species and for detection of Plasmodium vivax sporozoites in their head and thorax. Trap catches showed concordant peaks of Anopheles belenrae and An. kleini early in the study period and concordant peaks of An. pullus and An. sinensis later in the season. Three well defined peaks of the 107 sporozoite positive mosquitoes were observed: 34.6% were An. kleini, 23.4% were An. belenrae, 21.5% were An. sinensis, 19.6% were An. pullus, and 0.9% were An. lesteri. Estimation of the extrinsic incubation period from daily temperatures did not help identify preceding biting peaks of An. pullus and An. sinensis, when infection should have been acquired. We explore possible reasons for the sudden appearance and disappearance of sporozoite-infected mosquitoes, including the influx of infected mosquitoes from adjoining areas, and weather patterns. Regular surveillance for infected mosquitoes near border areas of the Republic of Korea may provide advance warning of increased malaria risk potential. C1 [Lee, Won-Ja] Korea Ctr Dis Control & Prevent, Natl Inst Hlth, Div Malaria & Parasit Dis, Gangoem Myeon 363951, Chungbuk Provin, South Korea. [Foley, Desmond H.; Wilkerson, Richard C.; Harrison, Genelle; Rueda, Leopoldo M.] Walter Reed Army Inst Res, Div Entomol, Silver Spring, MD 20910 USA. [Klein, Terry A.] 65th Med Brigade USAMEDDAC Korea, Force Hlth Protect & Prevent Med, Unit 15281, Seoul, South Korea. [Kim, Heung Chul; Kim, Myung-Soon] 65th Med Brigade, Multifunct Med Battal 168, Med Detachment 5, Unit 15247, Seoul, South Korea. RP Lee, WJ (reprint author), Korea Ctr Dis Control & Prevent, Natl Inst Hlth, Div Malaria & Parasit Dis, Gangoem Myeon 363951, Chungbuk Provin, South Korea. EM wonja@nih.go.kr RI Valle, Ruben/A-7512-2013; OI Foley, Desmond/0000-0001-7525-4601 FU Force Health Protection and Preventive Medicine, 65th Medical Brigade; Armed Forces Health Surveillance Center, Division of Global Emerging Infections Surveillance and Response System (AFHSC-GEIS), Silver Spring, MD; National Center for Medical Intelligence (NCMI), Fort Detrick, MD; Korea Centers for Disease Control and Prevention, Osong, Chungbuk Province, ROK; Korea National Institute of Health, Osong, Chungbuk Province FX We thank COL Hee-Choon S. Lee, Chief of Force Health Protection and Preventive Medicine, 65th Medical Brigade, for his support. Special thanks to Mr. Dong-Chan Kim (Daeseongdong village mayor), the ROK Army Commander, and ROK Army soldiers at JSA (provide security for Daeseongdong) for their assistance in mosquito collections. We also thank CAPT Clair Witt and Dr. Joel Gaydos, Armed Forces Health Surveillance Center, Global Emerging Infections Surveillance and Response System (AFHSC-GEIS), Silver Spring, MD, for their administrative and technical support. This work was supported through the joint partnership between the Armed Forces Health Surveillance Center, Division of Global Emerging Infections Surveillance and Response System (AFHSC-GEIS), Silver Spring, MD, the National Center for Medical Intelligence (NCMI), Fort Detrick, MD, the Korea Centers for Disease Control and Prevention, Osong, Chungbuk Province, ROK, and the Korea National Institute of Health, Osong, Chungbuk Province. This research was performed under a Memorandum of Understanding between the Walter Reed Army Institute of Research and the Smithsonian Institution, with institutional support provided by the AFHSC-GEIS and NCMI. The opinions and assertions contained herein are those of the authors and are not to be construed as official or reflecting the views of the Department of the Army or the Department of Defense. NR 20 TC 4 Z9 4 U1 0 U2 1 PU SOC VECTOR ECOLOGY PI CORONA PA 1966 COMPTON AVE, CORONA, CA 92881 USA SN 1081-1710 EI 1948-7134 J9 J VECTOR ECOL JI J. Vector Ecol. PD JUN PY 2012 VL 37 IS 1 BP 29 EP 36 DI 10.1111/j.1948-7134.2012.00197.x PG 8 WC Entomology SC Entomology GA 934KS UT WOS:000303443600004 PM 22548534 ER PT J AU Bulken-Hoover, JD Jackson, WM Ji, YM Volger, JA Tuan, RS Nesti, LJ AF Bulken-Hoover, Jamie D. Jackson, Wesley M. Ji, Youngmi Volger, Jared A. Tuan, Rocky S. Nesti, Leon J. TI Inducible Expression of Neurotrophic Factors by Mesenchymal Progenitor Cells Derived from Traumatically Injured Human Muscle SO MOLECULAR BIOTECHNOLOGY LA English DT Article DE Mesenchymal stem cells; Nerve regeneration; Tissue engineering; BDNF; Traumatized muscle; Neurotrophic induction ID PERIPHERAL-NERVE REGENERATION; MARROW STROMAL CELLS; STEM-CELLS; SCIATIC-NERVE; RETINOIC ACID; TISSUE; DIFFERENTIATION; REPAIR; TRANSPLANTATION; ANTIBODIES AB Peripheral nerve damage frequently accompanies musculoskeletal trauma and repair of these nerves could be enhanced by the targeted application of neurotrophic factors (NTFs), which are typically expressed by endogenous cells that support nerve regeneration. Injured muscle tissues express NTFs to promote reinnervation as the tissue regenerates, but the source of these factors from within the muscles is not fully understood. We have previously identified a population of mesenchymal progenitor cells (MPCs) in traumatized muscle tissue with properties that support tissue regeneration, and our hypothesis was that MPCs also secrete the NTFs that are associated with muscle tissue reinnervation. We determined that MPCs express genes associated with neurogenic function and measured the protein-level expression of specific NTFs with known functions to support nerve regeneration. We also demonstrated the effectiveness of a neurotrophic induction protocol to enhance the expression of the NTFs, which suggests that the expression of these factors may be modulated by the cellular environment. Finally, neurotrophic induction affected the expression of cell surface markers and proliferation rate of the MPCs. Our findings indicate that traumatized muscle-derived MPCs may be useful as a therapeutic cell type to enhance peripheral nerve regeneration following musculoskeletal injury. C1 [Bulken-Hoover, Jamie D.; Jackson, Wesley M.; Volger, Jared A.; Nesti, Leon J.] NIAMSD, Cartilage Biol & Orthopaed Branch, US Dept HHS, NIH, Bethesda, MD 20892 USA. [Bulken-Hoover, Jamie D.; Jackson, Wesley M.; Ji, Youngmi; Volger, Jared A.; Nesti, Leon J.] NIAMSD, Clin & Expt Orthopaed Lab, US Dept HHS, NIH, Bethesda, MD 20892 USA. [Bulken-Hoover, Jamie D.; Volger, Jared A.; Nesti, Leon J.] Walter Reed Army Med Ctr, Dept Orthopaed & Rehabil, Washington, DC 20307 USA. [Tuan, Rocky S.] Univ Pittsburgh, Ctr Cellular & Mol Engn, Dept Orthopaed Surg, Dept Bioengn,Sch Med, Pittsburgh, PA 15219 USA. RP Nesti, LJ (reprint author), NIAMSD, Cartilage Biol & Orthopaed Branch, US Dept HHS, NIH, 50 South Dr,Room 1525,MSC 8022, Bethesda, MD 20892 USA. EM rst13@pitt.edu; nestil@mail.nih.gov FU NIH [Z01 AR41131, 1ZIAAR041191]; Department of Defense Military Amputee Research at WRAMC [PO5-A011]; Comprehensive Neurosciences Program [CNP-2008-CR01]; Peer-Reviewed Orthopaedic Research Program [W81XWH-10-2-0084]; Commonwealth of Pennsylvania Department of Health FX The study was supported in part by the NIH Intramural Research Program (Z01 AR41131 and 1ZIAAR041191), grants from the Department of Defense Military Amputee Research Program at WRAMC (PO5-A011), Comprehensive Neurosciences Program (CNP-2008-CR01) and Peer-Reviewed Orthopaedic Research Program (W81XWH-10-2-0084), and the Commonwealth of Pennsylvania Department of Health was obtained. The authors thank Dr. Paul Manner, University of Washington, for providing human skeletal tissues, James Simone, NIAMS Flow Cytometry Group, for assistance with immunotyping, and Ibardo Zambrano and Richard Booth for technical assistance. NR 40 TC 2 Z9 2 U1 0 U2 3 PU HUMANA PRESS INC PI TOTOWA PA 999 RIVERVIEW DRIVE SUITE 208, TOTOWA, NJ 07512 USA SN 1073-6085 J9 MOL BIOTECHNOL JI Mol. Biotechnol. PD JUN PY 2012 VL 51 IS 2 BP 128 EP 136 DI 10.1007/s12033-011-9445-z PG 9 WC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology GA 936JQ UT WOS:000303587100004 PM 21904958 ER PT J AU Kozlowski, EJ Barcia, AM Tokish, JM AF Kozlowski, Erick J. Barcia, Anthony M. Tokish, John M. TI Meniscus Repair: The Role of Accelerated Rehabilitation in Return to Sport SO SPORTS MEDICINE AND ARTHROSCOPY REVIEW LA English DT Review DE meniscus; meniscal repair; rehabilitation ID IMMOBILIZATION; TEARS; KNEE AB With increasing understanding of the detrimental effects of the meniscectomized knee on outcomes and long-term durability, there is an ever increasing emphasis on meniscal preservation through repair. Repair in the young athlete is particularly challenging given the goals of returning to high-level sports. A healed meniscus is only the beginning of successful return to activity, and the understanding of "protection with progression" must be emphasized to ensure optimal return to performance. The principles of progression from low to high loads, single to multiplane activity, slow to high speeds, and stable to unstable platforms are cornerstones to this process. Emphasis on the kinetic chain environment that the knee will function within cannot be overemphasized. Communication between the operating surgeon and rehabilitation specialist is critical to optimizing effective return to sports. C1 [Barcia, Anthony M.; Tokish, John M.] Tripler Army Med Ctr, Dept Orthoped Surg, Honolulu, HI 96859 USA. [Kozlowski, Erick J.] USAF Acad, Colorado Springs, CO 80840 USA. RP Tokish, JM (reprint author), Tripler Army Med Ctr, Dept Orthoped Surg, 1 Jarrett White Rd, Honolulu, HI 96859 USA. NR 23 TC 5 Z9 6 U1 2 U2 21 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1062-8592 J9 SPORTS MED ARTHROSC JI Sports Med. Arthrosc. Rev. PD JUN PY 2012 VL 20 IS 2 BP 121 EP 126 DI 10.1097/JSA.0b013e318253d7c6 PG 6 WC Sport Sciences SC Sport Sciences GA 937JG UT WOS:000303654200011 PM 22555210 ER PT J AU Breckenridge-Sproat, S Johantgen, M Patrician, P AF Breckenridge-Sproat, Sara Johantgen, Meg Patrician, Patricia TI Influence of Unit-Level Staffing on Medication Errors and Falls in Military Hospitals SO WESTERN JOURNAL OF NURSING RESEARCH LA English DT Article DE nursing-sensitive indicators; medication errors; falls; generalized linear mixed models; multilevel data ID NURSE PRACTICE ENVIRONMENTS; PATIENT OUTCOMES; HEALTH-CARE; WORK INDEX; MORTALITY; QUALITY; ASSOCIATION; IMPROVEMENT; EVENTS; IMPACT AB This study examined unit-level associations of nurse staffing and workload, and the effect of the practice environment on adverse patient events. A secondary analysis was conducted of a longitudinal data set of 23 Army inpatient units from the Military Nursing Outcomes Database. Generalized Linear Mixed Modeling accommodated nested, nonparametric data. Staff category was found to be a significant predictor of medication errors and patient falls, but the relationship varied by unit type. Patient census had no effect on either outcome; however, a higher patient acuity was associated with an increase in both adverse events. The nursing practice environment mediated medication errors but not falls, in all unit types. Skill mix is important; however, additional components of staffing need consideration in producing positive patient outcomes. C1 [Breckenridge-Sproat, Sara] Walter Reed Army Med Ctr, USA Nurse Corps, Washington, DC 20307 USA. [Johantgen, Meg] Univ Maryland, Baltimore, MD 21201 USA. [Patrician, Patricia] Univ Alabama Birmingham, Birmingham, AL USA. RP Breckenridge-Sproat, S (reprint author), Walter Reed Army Med Ctr, USA Nurse Corps, 6900 Georgia Aveue, Washington, DC 20307 USA. EM sara.sproat@us.army.mil FU Uniformed Services University of the Health Sciences [MDA 905-01-1-TS12 N02-P06] FX The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This research was sponsored by the Tri-Service Nursing Research Program (TSNRP; grant #MDA 905-01-1-TS12 N02-P06: Military Nursing Outcomes Database [MilNOD], Phase IV: Analysis and Expansion, 2003), Uniformed Services University of the Health Sciences. NR 58 TC 9 Z9 10 U1 2 U2 13 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0193-9459 J9 WESTERN J NURS RES JI West. J. Nurs. Res. PD JUN PY 2012 VL 34 IS 4 BP 455 EP 474 DI 10.1177/0193945911407090 PG 20 WC Nursing SC Nursing GA 932WW UT WOS:000303322200003 PM 21540354 ER PT J AU Bernardo, E Parcianello, G Colombo, R Adair, JH Barnes, AT Hellmann, JR Jones, BH Kruise, J Swab, JJ AF Bernardo, E. Parcianello, G. Colombo, R. Adair, J. H. Barnes, A. T. Hellmann, J. R. Jones, B. H. Kruise, J. Swab, J. J. TI SiAlON ceramics from preceramic polymers and nano-sized fillers: Application in ceramic joining SO JOURNAL OF THE EUROPEAN CERAMIC SOCIETY LA English DT Article DE Precursors; Nanocomposites; SiAlON; Structural applications ID SILICON OXYCARBIDE GLASSES; ALUMINA NANOPARTICLES; MATRIX COMPOSITES; MULLITE SYNTHESIS; CARBIDE; FIBER AB Commercial polysiloxanes filled with alumina nano-particles have been employed for the preparation of beta-SiAlON-based ceramics in the temperature range 1450-1550 degrees C in nitrogen atmosphere. The formation of beta-SiAlON was found to be preceded by the formation of intermediate alumino-silicate phases. The SiAlON yield was affected by the occurrence of phase separation in the oxycarbide ceramic residue (SiOC) derived from the silicones and by the partial vaporization of silica, by reduction into gaseous SiO, leading to products with an oxide contamination, consisting of corundum. Filled silicones finally found a promising application in the ceramic joining, sandwiched between two pre-exisi.ing alpha-beta (Yb-)SiAlON pieces and treated at high temperature (1550 degrees C): with a proper formulation, a significant inter-diffusion was observed between the joining layer and the SiAlON parts, causing the evolution of a homogeneous joint region, matching the microstructure and the mechanical properties of the parent ceramics. The pre-oxidation of the SiAlON, generally aiding the wetting of the joining media prior to thermal treatment, showed no significant benefit on the microstructure. On the contrary, the addition of a small load during the thermal treatment allowed the formation of strong joints, not exhibiting any significant difference in mechanical properties with the parent material. (C) 2011 Elsevier Ltd. All rights reserved. C1 [Bernardo, E.; Parcianello, G.; Colombo, R.] Univ Padua, Dipartimento Ingn Meccan, Settore Mat, Padua, Italy. [Colombo, R.; Adair, J. H.; Barnes, A. T.; Hellmann, J. R.; Jones, B. H.; Kruise, J.] Penn State Univ, Dept Mat Sci & Engn, University Pk, PA 16802 USA. [Swab, J. J.] USA, Res Lab, Weap & Mat Res Directorate, Aberdeen, MD USA. RP Bernardo, E (reprint author), Univ Padua, Dipartimento Ingn Meccan, Settore Mat, Padua, Italy. EM enrico.bernardo@unipd.it OI Parcianello, Giulio/0000-0002-9703-3874; Adair, James/0000-0002-7516-5024; Bernardo, Enrico/0000-0003-4934-4405 NR 27 TC 18 Z9 18 U1 1 U2 48 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0955-2219 J9 J EUR CERAM SOC JI J. Eur. Ceram. Soc. PD JUN PY 2012 VL 32 IS 7 SI SI BP 1329 EP 1335 DI 10.1016/j.jeurceramsoc.2011.02.035 PG 7 WC Materials Science, Ceramics SC Materials Science GA 926QQ UT WOS:000302846400005 ER PT J AU Bragato, M Joshi, K Carlson, JB Tenorio, JAS Levendis, YA AF Bragato, Marcia Joshi, Kulbhushan Carlson, Joel B. Tenorio, Jorge A. S. Levendis, Yiannis A. TI Combustion of coal, bagasse and blends thereof Part I: Emissions from batch combustion of fixed beds of fuels SO FUEL LA English DT Article DE Coal; Biomass; Bagasse; Co-combustion; Emissions ID TIRE-DERIVED-FUEL; PULVERIZED COAL; PARTICULATE-EMISSIONS; BIOMASS; PYROLYSIS; GASIFICATION; MACERALS; REACTOR; DEVOLATILIZATION; POLYSTYRENE AB Batch combustion of fixed beds of coal, bagasse and blends thereof took place in a pre-heated two-stage electric laboratory furnace, under high-heating rates. The average input fuel/air equivalence ratios were similar for all fuels. The primary and secondary furnace temperatures were varied from 800 degrees C to 1000 degrees C. The effects of fuel blending, combustion staging, and operating furnace temperatures on the emissions from the two fuels were assessed. Furnace effluents were analyzed for carbon dioxide and for products of incomplete combustion (PIC) including CO, volatile and semi-volatile hydrocarbons, as well as particulate matter. Results showed that whereas CO2 was generated during both the observed sequential volatile matter and char combustion phases of the fuels, PICs were only generated during the volatile matter combustion phase. CO2 emissions were the highest from coal, whereas CO and other PIC emissions were the highest from bagasse. Under this particular combustion configuration, combustion of the volatile matter of the blends resulted in lower yields of PIC, than combustion of the volatiles of the neat fuels. Though CO and unburned hydrocarbons from coal as well as from the blends did not exhibit a clear trend with furnace temperature, such emissions from bagasse clearly increased with temperature. The presence of the secondary furnace (afterburner) typically reduced PIC, by promoting further oxidation of the primary furnace effluents. (C) 2012 Elsevier Ltd. All rights reserved. C1 [Bragato, Marcia; Joshi, Kulbhushan; Levendis, Yiannis A.] Northeastern Univ, Dept Mech & Ind Engn, Boston, MA 02116 USA. [Bragato, Marcia; Tenorio, Jorge A. S.] Univ Sao Paulo, Dept Met & Mat Eng, Polytech Sch, BR-05508900 Sao Paulo, Brazil. [Carlson, Joel B.] USA, SBCCOM, Natick Soldier Ctr, Natick, MA 01760 USA. RP Levendis, YA (reprint author), Northeastern Univ, Dept Mech & Ind Engn, Boston, MA 02116 USA. EM y.levendis@neu.edu FU Schlumberger Foundation FX M.B. acknowledges a visiting scholarship from the Schlumberger Foundation. NR 42 TC 12 Z9 12 U1 2 U2 21 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0016-2361 J9 FUEL JI Fuel PD JUN PY 2012 VL 96 IS 1 BP 43 EP 50 DI 10.1016/j.fuel.2011.12.072 PG 8 WC Energy & Fuels; Engineering, Chemical SC Energy & Fuels; Engineering GA 913DT UT WOS:000301853900004 ER PT J AU Bragato, M Joshi, K Carlson, JB Tenorio, JAS Levendis, YA AF Bragato, Marcia Joshi, Kulbhushan Carlson, Joel B. Tenorio, Jorge A. S. Levendis, Yiannis A. TI Combustion of coal, bagasse and blends thereof Part II: Speciation of PAH emissions SO FUEL LA English DT Article DE Coal; Biomass; Bagasse; Co-combustion; PAH emissions ID POLYCYCLIC AROMATIC-HYDROCARBONS; TIRE-DERIVED-FUEL; PULVERIZED COAL; BIOMASS; COCOMBUSTION; SOOT; OPPORTUNITY; STATION AB This work reports on emissions of unburned hydrocarbon species from batch combustion of fixed beds of coal, sugar-cane bagasse, and blends thereof in a pre-heated two-stage laboratory furnace operated in the temperature range of 800-1000 degrees C. The effects of fuel blending, combustion staging, and operating furnace temperatures on emissions of pollutants were assessed. Furnace effluents were analyzed for products of incomplete combustion (PICs) including CO, volatile and semi-volatile hydrocarbons, and particulate matter, as has been reported in Ref. [1]. Emitted unburned hydrocarbons include traces of potentially health-hazardous Polycyclic Aromatic Hydrocarbons (PAHs), which are the focus of this work. Under the batch combustion conditions implemented herein, PAH were only generated during the volatile combustion phase of the fuels. The most prevalent species were in descending order: naphthalene, acenaphthylene, phenanthrene, fluoranthene, pyrene, dibenzofuran, benzofuran, byphenyl, fluorene, 9H-fluoren-9-one, acephenantrylene, benzo[b] fluoranthene, 1-methyl-naphthalene; 2-methyl-naphthalene, benz[a] anthracene and benzo[a] pyrene. PAH yields were the highest from combustion of neat bagasse. Combustion of the blends resulted in lower yields of PAH, than combustion of either of their neat fuel constituents. Increasing the furnace operating temperature enhanced the PAH emissions from bagasse, but had little effect on those from the coal or from the blends. Flue gas treatment in a secondary-stage furnace, upon with additional air, typically reduced PAH yields by promoting oxidation of the primary-stage furnace effluents. (C) 2011 Elsevier Ltd. All rights reserved. C1 [Bragato, Marcia; Joshi, Kulbhushan; Levendis, Yiannis A.] Northeastern Univ, Dept Mech & Ind Engn, Boston, MA 02116 USA. [Bragato, Marcia; Tenorio, Jorge A. S.] Univ Sao Paulo, Dept Met & Mat Eng, Polytech Sch, BR-05508900 Sao Paulo, Brazil. [Carlson, Joel B.] USA, SBCCOM, Natick Soldier Ctr, Natick, MA 01760 USA. RP Levendis, YA (reprint author), Northeastern Univ, Dept Mech & Ind Engn, Boston, MA 02116 USA. EM y.levendis@neu.edu FU Schlumberger Foundation FX M.B. acknowledges a visiting scholarship from the Schlumberger Foundation. NR 31 TC 17 Z9 17 U1 1 U2 23 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0016-2361 J9 FUEL JI Fuel PD JUN PY 2012 VL 96 IS 1 BP 51 EP 58 DI 10.1016/j.fuel.2011.11.069 PG 8 WC Energy & Fuels; Engineering, Chemical SC Energy & Fuels; Engineering GA 913DT UT WOS:000301853900005 ER PT J AU Brandt, HE AF Brandt, Howard E. TI Tools in the Riemannian geometry of quantum computation SO QUANTUM INFORMATION PROCESSING LA English DT Article DE Quantum computing; Quantum circuits; Quantum complexity; Differential geometry; Riemannian geometry; Geodesics; Lax equation; Jacobi fields AB An introduction is first given of recent developments in the Riemannian geometry of quantum computation in which the quantum evolution is represented in the tangent space manifold of the special unitary unimodular group for n qubits. The Riemannian right-invariant metric, connection, curvature, geodesic equation for minimal complexity quantum circuits, Jacobi equation, and the lifted Jacobi equation for varying penalty parameter are reviewed. Sharpened tools for calculating the geodesic derivative are presented. The geodesic derivative may facilitate the numerical investigation of conjugate points and the global characteristics of geodesic paths in the group manifold, the determination of optimal quantum circuits for carrying out a quantum computation, and the determination of the complexity of particular quantum algorithms. C1 [Brandt, Howard E.] US Army Res Lab, Adelphi, MD USA. RP Brandt, HE (reprint author), US Army Res Lab, Adelphi, MD USA. EM howard.e.brandt.civ@mail.mil FU U.S. Army Research Laboratory FX The author wishes to thank Arun Pati for the invitation to present this lecture at the International Program on Quantum Information held at the Institute of Physics in Bhubaneswar, India, 10-15 January 2010. This research was supported by the U.S. Army Research Laboratory. NR 53 TC 0 Z9 0 U1 0 U2 3 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1570-0755 J9 QUANTUM INF PROCESS JI Quantum Inf. Process. PD JUN PY 2012 VL 11 IS 3 SI SI BP 787 EP 839 DI 10.1007/s11128-011-0290-6 PG 53 WC Physics, Multidisciplinary; Physics, Mathematical SC Physics GA 919TL UT WOS:000302351700010 ER PT J AU Kaewthamasorn, M Yahata, K Alexandre, JSF Xangsayarath, P Nakazawa, S Torri, M Sattabongkot, J Udomsangpetch, R Kaneko, O AF Kaewthamasorn, Morakot Yahata, Kazuhide Fils Alexandre, Jean Seme Xangsayarath, Phonepadith Nakazawa, Shusuke Torri, Motomi Sattabongkot, Jetsumon Udomsangpetch, Rachanee Kaneko, Osamu TI Stable allele frequency distribution of the polymorphic region of SURFIN4.2 in Plasmodium falciparum isolates from Thailand SO PARASITOLOGY INTERNATIONAL LA English DT Article DE Plasmodium falciparum; SURFIN; Positive diversifying selection; Allele frequency distribution ID MALARIA PARASITES; ANTIGENIC DIVERSITY; SELECTION; POPULATION; SOFTWARE; GENE AB Plasmodium falciparum SURFIN4.2 (PFD1160w) is a polymorphic protein expressed on the surface of parasite-infected erythrocytes. Such molecules are expected to be under strong host immune pressure, thus we analyzed the nucleotide diversity of the N-terminal extracellular region of SURFIN4.2 using P. falciparum isolates obtained from a malaria hypoendemic area of Thailand. The extracellular region of SURFIN4.2 was divided into four regions based on the amino acid sequence conservation among SURFIN members and the level of polymorphism among SURFIN4.2 sequences: N-terminal segment (Nter), a cysteine-rich domain (CRD), a variable region 1 (Var1), and a variable region 2 (Var2). Comparison between synonymous and non-synonymous substitutions, Tajima's D test, and Fu and Li's D* and F* tests detected signatures of positive selection on Var2 and to a lesser extent Var1 suggesting that these regions were likely under host immune pressure. Strong linkage disequilibrium was detected for nucleotide pairs separated by a distance of more than 1.5 kb, and 7 alleles among 19 alleles detected in 1988-1989 still circulated 14 years later, suggesting low recombination of the analyzed surf(4.2) sequence region in Thailand. The allele frequency distribution of polymorphic areas in Var2 did not differ between two groups collected in different time points, suggesting the allele frequency distribution of this region was stable for 14 years. The observed allele frequency distribution of SURFIN4.2 Var2 may be fixed in Thai P. falciparum population as similar to the observation for P. falciparum merozoite surface protein 1, for which a stable allele frequency distribution was reported. (C) 2011 Elsevier Ireland Ltd. All rights reserved. C1 [Kaewthamasorn, Morakot; Yahata, Kazuhide; Fils Alexandre, Jean Seme; Xangsayarath, Phonepadith; Nakazawa, Shusuke; Kaneko, Osamu] Nagasaki Univ, Inst Trop Med NEKKEN, Dept Protozool, Nagasaki 8528523, Japan. [Kaewthamasorn, Morakot; Yahata, Kazuhide; Fils Alexandre, Jean Seme; Xangsayarath, Phonepadith; Nakazawa, Shusuke; Kaneko, Osamu] Nagasaki Univ, Global Ctr Excellence Program, Nagasaki 8528523, Japan. [Torri, Motomi] Ehime Univ, Grad Sch Med, Dept Mol Parasitol, Toon, Ehime 7910295, Japan. [Sattabongkot, Jetsumon] Armed Forces Res Inst Med Sci, Dept Entomol, Bangkok 10400, Thailand. [Udomsangpetch, Rachanee] Mahidol Univ, Fac Sci, Dept Pathobiol, Bangkok 10400, Thailand. [Kaewthamasorn, Morakot] Chulalongkorn Univ, Fac Vet Sci, Dept Pathol, Parasitol Unit, Bangkok 10330, Thailand. [Fils Alexandre, Jean Seme] Ctr Nacl Control Enfermedades Trop, Santo Domingo, Dominican Rep. RP Kaneko, O (reprint author), Nagasaki Univ, Inst Trop Med NEKKEN, Dept Protozool, 1-12-4 Sakamoto, Nagasaki 8528523, Japan. EM morakot.k@chula.ac.th; kyahata@nagasaki-u.ac.jp; semefils@yahoo.es; xangsayalathdith@yahoo.com; nakazawa@nagasaki-u.ac.jp; torii@m.ehime-u.ac.jp; tmjetsumon@mahidol.ac.th; scrud@mahidol.ac.th; okaneko@nagasaki-u.ac.jp OI Kaewthamasorn, Morakot/0000-0003-3072-8708 FU Nagasaki University from the Ministry of Education, Culture, Sports, Science and Technology, Japan; [19590428] FX We thank S. Miyashita for her expertise. We are grateful to I. Sekine, head of the Nagasaki Red Cross Blood Center for human erythrocyte and plasma. This work was supported in part by Grants-in-Aids for Scientific Research 19590428 (to OK) and the Global COE Program, Nagasaki University (to OK) from the Ministry of Education, Culture, Sports, Science and Technology, Japan. The nucleotide sequence data reported in this paper are available in the GenBank (TM)/EMBL/DDBJ databases under the accession numbers: AB679835-AB679908. NR 23 TC 3 Z9 3 U1 1 U2 3 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 1383-5769 J9 PARASITOL INT JI Parasitol. Int. PD JUN PY 2012 VL 61 IS 2 BP 317 EP 323 DI 10.1016/j.parint.2011.12.003 PG 7 WC Parasitology SC Parasitology GA 915SH UT WOS:000302047200011 PM 22212242 ER PT J AU Kendall, TP Hromadka, TV Phillips, DD AF Kendall, T. P. Hromadka, T. V., II Phillips, D. D. TI An algorithm for optimizing CVBEM and BEM nodal point locations SO ENGINEERING ANALYSIS WITH BOUNDARY ELEMENTS LA English DT Article DE Collocation; BEM; CVBEM; Complex variable boundary element method; Boundary element method; Node locations AB The Complex Variable Boundary Element Method or CVBEM is a numerical technique for approximating particular partial differential equations such as the Laplace or Poisson equations (which frequently occur in physics and engineering problems, among many other fields of study). The advantage in using the CVBEM over traditional domain methods such as finite difference or finite element based methods includes the properties that the resulting CVBEM approximation is a function: (i) defined throughout the entire plane, (ii) that is analytic throughout the problem domain and almost everywhere on the problem boundary and exterior of the problem domain union boundary; (iii) is composed of conjugate two-dimensional real variable functions that are both solutions to the Laplace equation and are orthogonal such as to provide the "flow net" of potential and stream functions, among many other features. In this paper, a procedure is advanced that locates CVBEM nodal point locations on and exterior of the problem boundary such that error in matching problem boundary conditions is reduced. That is, locating the nodal points is part of modeling optimization process, where nodes are not restricted to be located on the problem boundary (as is the typical case) but instead locations are optimized throughout the exterior of the problem domain as part of the modeling procedure. The presented procedure results in nodal locations that achieve considerable error reduction over the usual methods of placing nodes on the problem boundary such as at equally spaced locations or other such procedures. Because of the significant error reduction observed, the number of nodes needed in the model is significantly reduced. It is noted that similar results occur with the real variable boundary element method (or BEM). The CVBEM and relevant nodal location optimization algorithm is programmed to run on program Mathematica, which provides extensive internal modeling and output graphing capabilities, and considerable levels of computational accuracy. The Mathematica source code is provided. (C) 2011 Elsevier Ltd. All rights reserved. C1 [Hromadka, T. V., II; Phillips, D. D.] US Mil Acad, Dept Math Sci, West Point, NY 10997 USA. RP Hromadka, TV (reprint author), US Mil Acad, Dept Math Sci, West Point, NY 10997 USA. EM ted@phdphdphd.com NR 5 TC 0 Z9 0 U1 0 U2 2 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0955-7997 J9 ENG ANAL BOUND ELEM JI Eng. Anal. Bound. Elem. PD JUN PY 2012 VL 36 IS 6 BP 979 EP 984 DI 10.1016/j.enganabound.2011.11.008 PG 6 WC Engineering, Multidisciplinary; Mathematics, Interdisciplinary Applications SC Engineering; Mathematics GA 911BF UT WOS:000301691600007 ER PT J AU Smith, S Baxter, R Menges, J Hromadka, TV Horton, S AF Smith, Samuel Baxter, Robert Menges, Joshua Hromadka, T. V., II Horton, Steven TI Real time boundary element node location optimization SO ENGINEERING ANALYSIS WITH BOUNDARY ELEMENTS LA English DT Article DE Boundary element method; Complex variable boundary element method; Optimization; Nodal locations; Real time ID FUNDAMENTAL-SOLUTIONS AB Boundary Element Method (BEM) computer models typically involve use of nodal points that are the locations of singular potential functions such as the logarithm or reciprocal of the Euclidean distance function. These singular functions are typically associated with the nodes themselves as far as identification. The Complex Variable Boundary Element Method (CVBEM) is another application of similar types of singular potential functions and includes other functions that are not singular but are fundamental solutions of the governing partial differential equation (PDE). These various singular potential functions form a basis whose span of linear combinations (either real or complex space, as appropriate) is a vector space. As part of the approximation approach, one determines that element in the vector space that is closest (usually in a least squares residual measure) to the exact solution of the PDE and related boundary conditions. Recent research on the types of basis functions used in a BEM or CVBEM approximation has shown that considerable improvement in computational accuracy and efficiency can be achieved by optimizing the location of the singular basis functions with respect to possible locations on the problem boundary and also locations exterior of the problem boundary (in general, exterior of the problem domain). To develop such optimum locations for the modeling nodes (and associated singular basis functions), the approach presented in this paper is to develop a Real Time Boundary Element Node Location module that enables the program user to click and drag nodes (one at a time) throughout the exterior of the problem domain (that is, nodes are allowed to be positioned on or arbitrarily close to the problem boundary, and also to be positioned exterior of the problem domain union boundary). The provided module interfaces with the CVBEM program, built within computer program Mathematica, so that various types of information flows to the display module as the node is moved, in real time. The information displayed includes a graphic of the problem boundary and domain, the exterior of the domain union boundary, evaluation points used to represent problem boundary conditions, nodal locations, modeling error in L-2 and also L-infinity norms, and a plot of problem boundary conditions versus modeling estimates on the problem boundary to enable a visualization of closeness of fit of the model to the problem boundary conditions. As the target node is moved on the screen, these various information forms change and are displayed to the program user, enabling the user to quickly navigate the target node towards a preferred location. Once a node is established at some optimized location, another node can then be clicked upon and dragged to new locations, while reducing modeling error in the process. (C) 2012 Elsevier Ltd. All rights reserved. C1 [Hromadka, T. V., II] US Mil Acad, Dept Math Sci, West Point, NY 10997 USA. [Smith, Samuel; Baxter, Robert; Menges, Joshua] US Mil Acad, CDT, West Point, NY 10997 USA. [Horton, Steven] US Mil Acad, Dept Math Sci, West Point, NY 10996 USA. RP Hromadka, TV (reprint author), US Mil Acad, Dept Math Sci, West Point, NY 10997 USA. EM Samuel.Smith@usma.edu; Robert.Baxter@usma.edu; Joshua.Menges@usma.edu; ted@phdphdphd.com; Steven.Horton@usma.edu NR 5 TC 1 Z9 1 U1 0 U2 1 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0955-7997 J9 ENG ANAL BOUND ELEM JI Eng. Anal. Bound. Elem. PD JUN PY 2012 VL 36 IS 6 BP 1049 EP 1052 DI 10.1016/j.enganabound.2011.11.020 PG 4 WC Engineering, Multidisciplinary; Mathematics, Interdisciplinary Applications SC Engineering; Mathematics GA 911BF UT WOS:000301691600014 ER PT J AU Cardello, AV Meiselman, HL Schutz, HG Craig, C Given, Z Lesher, LL Eicher, S AF Cardello, Armand V. Meiselman, Herbert L. Schutz, Howard G. Craig, Caelli Given, Zachary Lesher, Larry L. Eicher, Steven TI Measuring emotional responses to foods and food names using questionnaires SO FOOD QUALITY AND PREFERENCE LA English DT Article DE Emotions; Foods; Food names; Liking; Reliability; Underlying dimensions of emotions ID EXPERIENCE; CHOCOLATE; SCALE; MOOD AB Four experiments examined emotional responses to foods and food concepts (names). Emotional responses varied by foods/food names and included many different emotions. Correlations between foods and corresponding names ranged from +.66 to +.83, while session to session reliability in emotional responses for names ranged from +.50 to +.77 and for foods from +.37 to +.70. Liking ratings for the stimuli correlated highly with emotional valence. Principal Component Analysis uncovered similar dimensions underlying the emotional responses to foods and food names, including a number of positive dimensions and only one negative dimension. Published by Elsevier Ltd. C1 [Cardello, Armand V.; Given, Zachary] USA, Natick RD & E Ctr, Natick, MA 01760 USA. [Meiselman, Herbert L.] Herb Meiselman Training & Consulting, Rockport, MA 01966 USA. [Schutz, Howard G.] Univ Calif Davis, Davis, CA 95616 USA. [Eicher, Steven] Univ Connecticut, Storrs, CT 06269 USA. RP Cardello, AV (reprint author), USA, Natick RD & E Ctr, Natick, MA 01760 USA. EM armand.cardello@us.army.mil NR 22 TC 54 Z9 54 U1 1 U2 39 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0950-3293 J9 FOOD QUAL PREFER JI Food. Qual. Prefer. PD JUN PY 2012 VL 24 IS 2 BP 243 EP 250 DI 10.1016/j.foodqual.2011.12.002 PG 8 WC Food Science & Technology SC Food Science & Technology GA 902AG UT WOS:000301010400003 ER PT J AU Crutcher, SH Osei, A Biswas, A AF Crutcher, Sihon H. Osei, Albert Biswas, Anjan TI Nonlinear evolution equations for surface plasmons for nano-focusing at a Kerr/metallic interface and tapered waveguide SO OPTICS AND LASER TECHNOLOGY LA English DT Article DE Spatial plasmon solitons; Surface plasmons; Tapered waveguide ID POWER-LAW NONLINEARITY; SPATIAL SOLITONS; SCHRODINGERS EQUATION; POLARITON SOLITONS; 1-SOLITON SOLUTION; OPTICAL SOLITONS; MEDIA AB Maxwell's equations for a metallic and nonlinear Kerr interface waveguide at the nanoscale can be approximated to a (1+1) D Nonlinear Schrodinger type model equation (NLSE) with appropriate assumptions and approximations. Theoretically, without losses or perturbations spatial plasmon solitons profiles are easily produced. However, with losses, the amplitude or beam profile is no longer stationary and adiabatic parameters have to be considered to understand propagation. For this model, adiabatic parameters are calculated considering losses resulting in linear differential coupled integral equations with constant definite integral coefficients not dependent on the transverse and longitudinal coordinates. Furthermore, by considering another configuration, a waveguide that is an M-NL-M (metal-nonlinear Kerr-metal) that tapers, the tapering can balance the loss experienced at a non-tapered metal/nonlinear Kerr interface causing attenuation of the beam profile, so these spatial plasmon solitons can be produced. In this paper taking into consideration the (1+1)D NLSE model for a tapered waveguide, we derive a one soliton solution based on He's Semi-Inverse Variational Principle (HPV). Published by Elsevier Ltd. C1 [Crutcher, Sihon H.] USA, Res Dev & Engn Command, Redstone Arsenal, AL 35898 USA. [Osei, Albert] Oakwood Univ, Dept Math & Comp Sci, Huntsville, AL 35896 USA. [Biswas, Anjan] Delaware State Univ, Dept Math Sci, Dover, DE 19901 USA. RP Crutcher, SH (reprint author), USA, Res Dev & Engn Command, Bldg 5400, Redstone Arsenal, AL 35898 USA. EM sihon.crutcher@us.army.mil RI Biswas, Anjan /D-8500-2012 NR 38 TC 3 Z9 3 U1 0 U2 7 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0030-3992 EI 1879-2545 J9 OPT LASER TECHNOL JI Opt. Laser Technol. PD JUN PY 2012 VL 44 IS 4 BP 1156 EP 1162 DI 10.1016/j.optlastec.2011.09.027 PG 7 WC Optics; Physics, Applied SC Optics; Physics GA 890BA UT WOS:000300118900068 ER PT J AU Zhang, SS AF Zhang, Sheng S. TI Role of LiNO3 in rechargeable lithium/sulfur battery SO ELECTROCHIMICA ACTA LA English DT Article DE Lithium/sulfur battery; LiNO3; Polysulfide; Li anode; Cycle life ID SULFUR BATTERIES; ELECTROCHEMICAL PERFORMANCE; CYCLE PROPERTY; CATHODE; ELECTROLYTE; IMPROVEMENT; COMPOSITES AB In this work we study the effect of LiNO3 on the Li anode and sulfur cathode, respectively, of Li/S battery by using a Li/Li symmetric cell and a liquid Li/Li2S9 cell. On the Li anode, LiNO3 participates in the formation of a stable passivation film, and the resulting passivation film grows infinitely with the consumption of LiNO3. The passivation film formed with LiNO3 is known to effectively suppress the redox shuttle of the dissolved lithium polysulfides on Li anode. On the cathode, LiNO3 undergoes a large and irreversible reduction starting at 1.6V in the first discharge, and the irreversible reduction disappears in the subsequent cycles. Moreover, the insoluble reduction products of LiNO3 on the cathode adversely affect the redox reversibility of sulfur cathode. These results indicate that both the Li anode and sulfur cathode consume LiNO3, and that the best benefit of LiNO3 to Li/S battery occurs at the potentials higher than 1.6 V. By limiting the irreversible reduction of LiNO3 on the cathode, we have shown that the Li/S cell with a 0.2 m LiNO3 as the co-salt can provide a stable capacity of similar to 500 mAh g(-1). Published by Elsevier Ltd. C1 USA, Res Lab, RDRL SED C, Adelphi, MD 20783 USA. RP Zhang, SS (reprint author), USA, Res Lab, RDRL SED C, Adelphi, MD 20783 USA. EM shengshui.zhang.civ@mail.mil RI Zhang, Sheng/A-4456-2012 OI Zhang, Sheng/0000-0003-4435-4110 NR 24 TC 259 Z9 268 U1 41 U2 349 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0013-4686 J9 ELECTROCHIM ACTA JI Electrochim. Acta PD MAY 30 PY 2012 VL 70 BP 344 EP 348 DI 10.1016/j.electacta.2012.03.081 PG 5 WC Electrochemistry SC Electrochemistry GA 948IO UT WOS:000304497000045 ER PT J AU Hudiono, YC Miller, AL Gibson, PW LaFrate, AL Noble, RD Gin, DL AF Hudiono, Yeny C. Miller, A. Lee, II Gibson, Phillip W. LaFrate, Andrew L. Noble, Richard D. Gin, Douglas L. TI A Highly Breathable Organic/Inorganic Barrier Material that Blocks the Passage of Mustard Agent Simulants SO INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH LA English DT Article ID CHEMICAL WARFARE AGENTS; WATER; PROTECTION; MEMBRANES; ZEOLITES AB Garment materials that provide protection against exposure to toxic chemical warfare agents (CWAs) not only require the ability to block the passage of these toxic compounds in vapor form but also the ability to transport water vapor to allow cooling for the wearer. Only a very limited number of examples of such "breathable" CWA barrier materials are known. A new type of reactive organic/inorganic composite film material is presented that has a very high water vapor transport rate (>1800 g m(-2) day(-1) for a 220-mu m-thick film) and the ability to completely block penetration of the mustard agent simulant, 2-chloroethyl ethyl sulfide (CEES), after 22 h of continuous exposure. This new composite material is based on two components: (1) a cross-linked, diol-functionalized room-temperature ionic liquid polymer that serves as a dense, flexible hydrophilic matrix, and (2) a basic zeolite (sodium zeolite-Y (NaY)) that serves as an inexpensive, nucleophilic additive that chemically degrades the CEES as it enters the film. Preliminary FT-IR studies on this new reactive barrier material suggest that the OH groups on the ionic polymer not only facilitates water vapor transport but may also help activate mustard-type vapors for reaction with the imbedded NaY. C1 [Hudiono, Yeny C.; Miller, A. Lee, II; LaFrate, Andrew L.; Noble, Richard D.; Gin, Douglas L.] Univ Colorado, Dept Chem & Biol Engn, Boulder, CO 80309 USA. [Miller, A. Lee, II; LaFrate, Andrew L.; Gin, Douglas L.] Univ Colorado, Dept Chem & Biochem, Boulder, CO 80309 USA. [Gibson, Phillip W.] USA, Natick Soldier Res Dev & Engn Ctr, Natick, MA 01760 USA. RP Noble, RD (reprint author), Univ Colorado, Dept Chem & Biol Engn, Boulder, CO 80309 USA. EM nobler@colorado.edu; gin@spot.colorado.edu RI Gibson, Phillip/D-2398-2010; OI Gibson, Phillip/0000-0002-6172-4438; GIN, DOUGLAS/0000-0002-6215-668X FU U.S. Defense Threat Reduction Agency [HDTRA1-08-1-0028]; U.S. Army Research Office [AB07CBT010] FX We thank the U.S. Defense Threat Reduction Agency (HDTRA1-08-1-0028) and the U.S. Army Research Office (AB07CBT010) for funding this research. NR 21 TC 1 Z9 1 U1 5 U2 29 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0888-5885 J9 IND ENG CHEM RES JI Ind. Eng. Chem. Res. PD MAY 30 PY 2012 VL 51 IS 21 BP 7453 EP 7456 DI 10.1021/ie202977e PG 4 WC Engineering, Chemical SC Engineering GA 949JV UT WOS:000304573400035 ER PT J AU Toonen, RC Cole, MW AF Toonen, Ryan C. Cole, M. W. TI Third-order electric-field-induced dipolar resonances from patterned barium-strontium-titanate thin-films SO APPLIED PHYSICS LETTERS LA English DT Article ID SRTIO3; TEMPERATURE; CAPACITORS AB Using microwave reflection spectroscopy, the complex permittivities of etch defined, 240 nm thick, (Ba0.6Sr0.4)TiO3, thin films have been measured over the frequency range of (1 to 4) GHz. Anomalous electric-field-induced electro-acoustic resonances were observed and characterized as a function of extrinsic electric field magnitude, ambient temperature, and sample diameter. The real and imaginary parts of the measured permittivities were fit to frequency-dependent functions derived from the Lorentz oscillator model. From these functions, extracted static dielectric constants were found to display excellent agreement with a closed-form expression derived by calculating third-order nonlinear susceptibility from the Landau-Devonshire-Ginzberg model. [http://dx.doi.org/10.1063/1.4723692] C1 [Toonen, Ryan C.; Cole, M. W.] USA, Weap & Mat Res Directorate, Res Lab, RDRL WMM E, Aberdeen Proving Ground, MD 21005 USA. RP Toonen, RC (reprint author), USA, Weap & Mat Res Directorate, Res Lab, RDRL WMM E, Aberdeen Proving Ground, MD 21005 USA. EM ryan.c.toonen.civ@mail.mil FU ARL Director's Research Initiative [FY10-WMR-27] FX We thank M. P. Ivill and C. V. Weiss for their discussions. Funding for these efforts was provided by an award from the ARL Director's Research Initiative (FY10-WMR-27). NR 16 TC 4 Z9 4 U1 0 U2 3 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD MAY 28 PY 2012 VL 100 IS 22 AR 222908 DI 10.1063/1.4723692 PG 5 WC Physics, Applied SC Physics GA 952WC UT WOS:000304823800041 ER PT J AU Sokolove, J Bromberg, R Deane, KD Lahey, LJ Derber, LA Chandra, PE Edison, JD Gilliland, WR Tibshirani, RJ Norris, JM Holers, VM Robinson, WH AF Sokolove, Jeremy Bromberg, Reuven Deane, Kevin D. Lahey, Lauren J. Derber, Lezlie A. Chandra, Piyanka E. Edison, Jess D. Gilliland, William R. Tibshirani, Robert J. Norris, Jill M. Holers, V. Michael Robinson, William H. TI Autoantibody Epitope Spreading in the Pre-Clinical Phase Predicts Progression to Rheumatoid Arthritis SO PLOS ONE LA English DT Article ID CYCLIC CITRULLINATED PEPTIDE; CHRONIC INFLAMMATORY DISEASE; TOLL-LIKE RECEPTORS; C-REACTIVE PROTEIN; DOUBLE-BLIND; UP-REGULATION; BLOOD-DONORS; UNDIFFERENTIATED ARTHRITIS; AUTOIMMUNE ARTHRITIS; IMMUNE-COMPLEXES AB Rheumatoid arthritis (RA) is a prototypical autoimmune arthritis affecting nearly 1% of the world population and is a significant cause of worldwide disability. Though prior studies have demonstrated the appearance of RA-related autoantibodies years before the onset of clinical RA, the pattern of immunologic events preceding the development of RA remains unclear. To characterize the evolution of the autoantibody response in the preclinical phase of RA, we used a novel multiplex autoantigen array to evaluate development of the anti-citrullinated protein antibodies (ACPA) and to determine if epitope spread correlates with rise in serum cytokines and imminent onset of clinical RA. To do so, we utilized a cohort of 81 patients with clinical RA for whom stored serum was available from 1-12 years prior to disease onset. We evaluated the accumulation of ACPA subtypes over time and correlated this accumulation with elevations in serum cytokines. We then used logistic regression to identify a profile of biomarkers which predicts the imminent onset of clinical RA (defined as within 2 years of testing). We observed a time-dependent expansion of ACPA specificity with the number of ACPA subtypes. At the earliest timepoints, we found autoantibodies targeting several innate immune ligands including citrullinated histones, fibrinogen, and biglycan, thus providing insights into the earliest autoantigen targets and potential mechanisms underlying the onset and development of autoimmunity in RA. Additionally, expansion of the ACPA response strongly predicted elevations in many inflammatory cytokines including TNF-alpha, IL-6, IL-12p70, and IFN-gamma. Thus, we observe that the preclinical phase of RA is characterized by an accumulation of multiple autoantibody specificities reflecting the process of epitope spread. Epitope expansion is closely correlated with the appearance of preclinical inflammation, and we identify a biomarker profile including autoantibodies and cytokines which predicts the imminent onset of clinical arthritis. C1 [Sokolove, Jeremy; Bromberg, Reuven; Lahey, Lauren J.; Chandra, Piyanka E.; Robinson, William H.] Stanford Univ, Dept Med, Div Rheumatol, Sch Med, Stanford, CA 94305 USA. [Lahey, Lauren J.; Chandra, Piyanka E.; Tibshirani, Robert J.] Stanford Univ, Dept Stat, Sch Med, Stanford, CA 94305 USA. [Tibshirani, Robert J.] Stanford Univ, Dept Hlth Res & Policy, Sch Med, Stanford, CA 94305 USA. [Sokolove, Jeremy; Bromberg, Reuven; Robinson, William H.] VA Palo Alto Hlth Care Syst, Palo Alto, CA USA. [Deane, Kevin D.; Derber, Lezlie A.; Holers, V. Michael] Univ Colorado, Div Rheumatol, Dept Med, Sch Med, Aurora, CO USA. [Edison, Jess D.; Gilliland, William R.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [Norris, Jill M.] Univ Colorado, Dept Epidemiol, Colorado Sch Publ Hlth, Aurora, CO USA. RP Sokolove, J (reprint author), Stanford Univ, Dept Med, Div Rheumatol, Sch Med, Stanford, CA 94305 USA. EM sokolove@stanford.edu; wrobins@stanford.edu FU United States National Institutes of Health; American College of Rheumatology FX This study was funded by grants from the United States National Institutes of Health and the American College of Rheumatology. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 53 TC 133 Z9 134 U1 0 U2 12 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD MAY 25 PY 2012 VL 7 IS 5 AR e35296 DI 10.1371/journal.pone.0035296 PG 9 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 959UY UT WOS:000305342300003 PM 22662108 ER PT J AU Fleischman, MS Lee, BS Rodriguez-Santiago, V Chhasatia, V Sun, Y Pappas, DD AF Fleischman, Michelle S. Lee, Brandon S. Rodriguez-Santiago, Victor Chhasatia, Viral Sun, Ying Pappas, Daphne D. TI Hybrid method involving atmospheric plasma treatment and inkjet deposition for the development of conductive patterns on flexible polymers SO SURFACE & COATINGS TECHNOLOGY LA English DT Article DE Atmospheric dielectric barrier discharge; Helium-oxygen plasma; Helium-water vapor plasma; Polyethylene naphthalate; Inkjet printing; Conductive polymer ID SURFACE MODIFICATION; POLYESTER FABRICS; JET; PERFORMANCE; DROPLETS; BLENDS; LIQUID AB In this study, the flexible polymer substrate polyethylene naphthalate (PEN) was modified under two different plasma chemistries, namely helium-oxygen (He-O-2) and helium-water vapor (He-H2O) plasmas at atmospheric pressure and room temperature. Surface changes related to wettability, chemical functionalization, surface energy, and morphology after plasma treatment were investigated using water contact angle (WCA) goniometry, X-ray photoelectron spectroscopy (XPS), and atomic force microscopy (AFM). Each plasma resulted in a more hydrophilic PEN surface, with WCA decreasing by 68% and 85% for He-O-2 and He-H2O plasma treated PEN, respectively, after only 1.0 s of exposure. An aging study of plasma treated PEN shows an increase in WCA that is still 30 degrees lower than that of the as-received PEN after 1 month. XPS and AFM results show that improved wettability of the plasma modified PEN is due to the oxidation of the surface and not due to the increased surface roughness. To promote a roll-to-roll process of atmospheric plasma treatment and inkjet deposition, printing was performed using the conductive polymer poly(3,4-ethylenedioxythiophene) poly(styrenesulfonate) (PEDOT:PSS) on the as-received and plasma treated PEN surfaces where the shape and morphology of the lines were studied. Each plasma treated PEN surface exhibited well-defined, uniform inkjet-printed lines due to the improved wettability and increased surface energy. After scanning electron microscopy (SEM) analysis of the PEDOT:PSS dispersion of a single drop on each substrate, the He-H2O plasma treated surface led to less agglomeration of PEDOT:PSS and a more homogeneous drop deposit. Published by Elsevier B.V. C1 [Fleischman, Michelle S.; Rodriguez-Santiago, Victor; Pappas, Daphne D.] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. [Lee, Brandon S.; Chhasatia, Viral; Sun, Ying] Drexel Univ, Dept Mech Engn & Mech, Philadelphia, PA 19104 USA. RP Pappas, DD (reprint author), USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. EM daphne.pappas@us.army.mil RI Rodriguez-Santiago, Victor/B-7447-2011; OI Pappas, Daphne/0000-0002-5746-8873; Rodriguez-Santiago, Victor/0000-0002-8389-5414 FU National Science Foundation [CAREER-0968927]; U.S. Department of Energy; USARL FX This project was supported in part by an appointment to the Internship/Research Participation Program for the U.S. Army Research Laboratory administered by the Oak Ridge Institute for Science and Education through an agreement between the U.S. Department of Energy and the USARL. We thank the National Science Foundation for partially supporting this work under grant no. CAREER-0968927. NR 26 TC 8 Z9 8 U1 3 U2 33 PU ELSEVIER SCIENCE SA PI LAUSANNE PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND SN 0257-8972 J9 SURF COAT TECH JI Surf. Coat. Technol. PD MAY 25 PY 2012 VL 206 IS 19-20 BP 3923 EP 3930 DI 10.1016/j.surfcoat.2012.03.062 PG 8 WC Materials Science, Coatings & Films; Physics, Applied SC Materials Science; Physics GA 963ZB UT WOS:000305662400016 ER PT J AU Goff, JA Lawson, DE Willems, BA Davis, M Gulick, SPS AF Goff, John A. Lawson, Daniel E. Willems, Bryce A. Davis, Marcy Gulick, Sean P. S. TI Morainal bank progradation and sediment accumulation in Disenchantment Bay, Alaska: Response to advancing Hubbard Glacier SO JOURNAL OF GEOPHYSICAL RESEARCH-EARTH SURFACE LA English DT Article ID TIDEWATER GLACIERS; GROUNDING-LINE; GLACIMARINE SEDIMENTATION; SPITSBERGEN FJORDS; LECONTE GLACIER; OUTLET GLACIERS; MUIR INLET; SEA-LEVEL; ICE; USA AB Morainal banks are primary features at the margins of advancing and stable to quasi-stable temperate tidewater glaciers, yet their roles in glacier dynamics and terminus stability are poorly defined by submarine observations. Analysis of new and archival multibeam data and Landsat images of the advancing Hubbard Glacier, southeast Alaska, reveal that between 1978 and 2010 the ice face and morainal bank advanced together at an average rate of similar to 34 m/yr, varying spatially and temporally between 14 and 80 m/yr. Morphological features including gullies and a boulder lag suggest cyclical deposition and gravitational erosion on the proximal slope of the morainal bank (15-18 degrees), and possible ice pushing in an area without recent sedimentation. In contrast, the morainal bank of the nearby, quasi-stable (surging) Turner Glacier advanced steadily since 1978 by proximal sedimentation on the steep fjord wall below its hanging valley. Sedimentation in the deep (> 220 m) basin of Disenchantment Bay increased from 0.88 m/yr spanning 1978 to 1999, to 1.22 m/yr thereafter. This change appears to be a combined response to glacier advance and sediment dispersal farther down-fjord, and to an increase in sediment yield from other glacial and non-glacial sources. Analysis of Hubbard Glacier illustrates the direct correlation between movement of the terminus and morainal bank in advancing the grounding line of a marine-terminating glacier, and that morainal banks provide a fundamental stabilizing role for advance into a deep-water fjord, compensating for changes in water depth at the grounding line. C1 [Goff, John A.; Davis, Marcy; Gulick, Sean P. S.] Univ Texas Austin, Inst Geophys, Jackson Sch Geosci, Austin, TX 78758 USA. [Lawson, Daniel E.] USA, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. [Willems, Bryce A.] Univ Alaska Anchorage, Dept Geol Sci, Anchorage, AK USA. RP Goff, JA (reprint author), Univ Texas Austin, Inst Geophys, Jackson Sch Geosci, 10100 Burnet Rd, Austin, TX 78758 USA. EM goff@ig.utexas.edu RI Gulick, Sean/C-1039-2008 OI Gulick, Sean/0000-0003-4740-9068 FU NPS staff at Wrangell-St Elias National Park and Preserve; National Science Foundation RAPID [NSF-OPP/ARC-0949775]; UTIG Innovations and Opportunity [2480] FX The authors are extremely grateful to Captain Mark Sappington for his tremendous skill at navigating the often treacherous waters around Hubbard Glacier. We also thank: USFS Yakutat Ranger District, particularly Lee Benson, for logistical support, use of maintenance facilities and storage; the NPS staff at Wrangell-St Elias National Park and Preserve for support and discussions; and pilot Les Hartley, Alsek Air, for logistical support. We gratefully acknowledge Luke Trusel for providing the 2006 bathymetry data and Dan Duncan for assistance in reprocessing the 1999 multibeam data. Lawson was funded under National Science Foundation RAPID Grant NSF-OPP/ARC-0949775. Goff, Davis and Gulick were funded under a UTIG Innovations and Opportunity Grant UTIG Contribution 2480. NR 67 TC 5 Z9 5 U1 1 U2 14 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA SN 0148-0227 J9 J GEOPHYS RES-EARTH JI J. Geophys. Res.-Earth Surf. PD MAY 25 PY 2012 VL 117 AR F02031 DI 10.1029/2011JF002312 PG 15 WC Geosciences, Multidisciplinary SC Geology GA 949CI UT WOS:000304553000002 ER PT J AU Milikh, GM Demekhov, A Vartanyan, A Mishin, EV Huba, J AF Milikh, G. M. Demekhov, A. Vartanyan, A. Mishin, E. V. Huba, J. TI A new model for formation of artificial ducts due to ionospheric HF-heating SO GEOPHYSICAL RESEARCH LETTERS LA English DT Article ID RADIO-WAVES; LATITUDE IONOSPHERE AB We present the results of numerical simulations of artificial ducts during high-power HF heating performed by a novel model accounting for the effect of self-action. This effect interferes with the HF-plasma matching in the heated region and hence with electron heating. The model satisfactorily explains recent experimental observations. It helps for choosing the heating parameters optimal for duct formation, such as proper duration of the heating pulse and its frequency. It also suggests that distortion of the ducts caused by the self-action effect can be avoided by down-chirping the heating frequency. The down-chirping rates needed to suppress such distortions are evaluated. C1 [Milikh, G. M.; Vartanyan, A.] Univ Maryland, Dept Phys, College Pk, MD 20742 USA. [Demekhov, A.] Radiophys Inst, Nizhnii Novgorod, Russia. [Mishin, E. V.] USA, Res Lab, Kirtland AFB, NM USA. [Huba, J.] USN, Res Lab, Washington, DC 20375 USA. RP Milikh, GM (reprint author), Univ Maryland, Dept Phys, College Pk, MD 20742 USA. EM milikh@astro.umd.edu RI Demekhov, Andrei/F-1444-2016 OI Demekhov, Andrei/0000-0002-8062-8492 FU DARPA [N684228]; ONR [NAVY.N0017302C60]; MURI [N000140710789]; Air Force Office of Scientific Research FX GM and AV were supported by DARPA via a subcontract N684228 with BAE Systems and also by the ONR grants NAVY.N0017302C60 and MURI N000140710789. EM was supported by the Air Force Office of Scientific Research. The authors are grateful to Dennis Papadopoulos for helpful discussions. NR 18 TC 5 Z9 6 U1 0 U2 1 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA SN 0094-8276 J9 GEOPHYS RES LETT JI Geophys. Res. Lett. PD MAY 24 PY 2012 VL 39 AR L10102 DI 10.1029/2012GL051718 PG 4 WC Geosciences, Multidisciplinary SC Geology GA 949FC UT WOS:000304561000003 ER PT J AU Shukla, MK Hill, F AF Shukla, Manoj K. Hill, Frances TI Can an alpha-Anomer of the Trinitro Form of D-Glucopyranose Be More Easily Hydrolyzed in Alkaline Environment than the beta-Anomer? A Detailed Theoretical Analysis SO JOURNAL OF PHYSICAL CHEMISTRY A LA English DT Article ID CELLULOSE NITRATE; NITROCELLULOSE; KINETICS AB Comprehensive computational investigations of detailed alkaline hydrolysis reaction pathways of the alpha-anomeric form of nitrocellulose monomer (2,3,6-trinitro-alpha-D-glucopyranose) in the C-4(1) chair conformation within the S(N)2 framework in the gas phase and in bulk water solution are reported. Geometries of reactant complexes, transition states, intermediates, and completely denitrated product were optimized at the density functional theory (DFT) level using the B3LYP functional and the 6-311G(d,p) basis set both in the gas phase and in the bulk water solution. The effect of bulk water was modeled using the polarizable continuum model (PCM) approach. The nature of the potential energy surface of the local minima and transition states was ascertained through vibrational frequency analysis. Intrinsic reaction coordinate (IRC) calculations were also performed to validate the computed transition state structures. Effect of electron correlation on computed energies was considered through a single point energy calculation at the MP2 level using the cc-pVTZ basis set. It was revealed that the presence of hydrogen bonds between the attacking OH- ion and various hydrogen bond donating sites (including CH sites) of monomer was necessary for stabilization of the transition state. It was revealed that the a-anomer will be more reactive than the beta-anomer with regard to the denitration reaction. The role of entropy and the denitration ability of various sites are also discussed. C1 [Shukla, Manoj K.; Hill, Frances] USA, Environm Lab, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Shukla, MK (reprint author), USA, Environm Lab, Engineer Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM manoj.k.shukla@usace.army.mil NR 19 TC 1 Z9 1 U1 1 U2 9 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1089-5639 J9 J PHYS CHEM A JI J. Phys. Chem. A PD MAY 24 PY 2012 VL 116 IS 20 BP 4909 EP 4921 DI 10.1021/jp300190w PG 13 WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical SC Chemistry; Physics GA 946GD UT WOS:000304338600011 PM 22540769 ER PT J AU Uchimiya, M Bannon, DI Wartelle, LH Lima, IM Klasson, KT AF Uchimiya, Minori Bannon, Desmond I. Wartelle, Lynda H. Lima, Isabel M. Klasson, K. Thomas TI Lead Retention by Broiler Litter Biochars in Small Arms Range Soil: Impact of Pyrolysis Temperature SO JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY LA English DT Article DE heavy metal; bioavailability; manure; fertilizer; biomass; phosphorus ID CONTAMINATED SOILS; IN-VITRO; BIOAVAILABILITY; PHOSPHORUS; PHOSPHATE; BIOMASS; WASTE; AMENDMENTS; TOXICITY; RELEASE AB Phosphorus-rich manure biochar has a potential for stabilizing Pb and other heavy metal contaminants, as well as serving as a sterile fertilizer. In this study, broiler litter biochars produced at 350 and 650 degrees C were employed to understand how biochar's elemental composition (P, K, Ca, Mg, Na, Cu, Pb, Sb, and Zn) affects the extent of heavy metal stabilization. Soil incubation experiments were conducted using a sandy, slightly acidic (pH 6.11) Pb-contaminated (19906 mg kg(-1) total Pb primarily as PbCO3) small arms range (SAR) soil fraction (<250 mu m) amended with 2-20 wt % biochar. The Pb stabilization in pH 4.9 acetate buffer reached maximum at lower (2-10 wt %) biochar amendment rate, and 350 degrees C biochar containing more soluble P was better able to stabilize Pb than the 650 degrees C biochar. The 350 degrees C biochar consistently released greater amounts of P, K, Mg, Na, and Ca than 650 degrees C biochar in both unbuffered (pH 4.5 sulfuric acid) and buffered (pH 4.9 acetate) systems, despite 1.9-4.5-fold greater total content of the 650 degrees C biochar. Biochars, however, did not influence the total extractable Pb over three consecutive equilibration periods consisting of (1) 1 week in pH 4.5 sulfuric acid (simulated leaching by rainfall), (2) 1 week in pH 4.9 acetate buffer (standard solution for toxicity characteristic leaching procedure), and (3) 1 h in pH 1.5 glycine at 37 degrees C (in vitro bioaccessibility procedure). Overall, lower pyrolysis temperature was favorable for stabilizing Pb (major risk driver of SAR soils) and releasing P, K, Ca, and other plant nutrients in a sandy acidic soil. C1 [Uchimiya, Minori; Wartelle, Lynda H.; Lima, Isabel M.; Klasson, K. Thomas] ARS, So Reg Res Ctr, USDA, New Orleans, LA 70124 USA. [Bannon, Desmond I.] USA, Army Inst Publ Hlth, Publ Hlth Command, Aberdeen Proving Ground, MD 21010 USA. RP Uchimiya, M (reprint author), ARS, So Reg Res Ctr, USDA, 1100 Robert E Lee Blvd, New Orleans, LA 70124 USA. EM sophie.uchimiya@ars.usda.gov OI Klasson, K. Thomas/0000-0003-3358-3081 NR 50 TC 24 Z9 25 U1 2 U2 71 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0021-8561 J9 J AGR FOOD CHEM JI J. Agric. Food Chem. PD MAY 23 PY 2012 VL 60 IS 20 BP 5035 EP 5044 DI 10.1021/jf300825n PG 10 WC Agriculture, Multidisciplinary; Chemistry, Applied; Food Science & Technology SC Agriculture; Chemistry; Food Science & Technology GA 945OJ UT WOS:000304285600003 PM 22548418 ER PT J AU Mukhopadhyay, J Braig, HR Rowton, ED Ghosh, K AF Mukhopadhyay, Jaba Braig, Henk R. Rowton, Edgar D. Ghosh, Kashinath TI Naturally Occurring Culturable Aerobic Gut Flora of Adult Phlebotomus papatasi, Vector of Leishmania major in the Old World SO PLOS ONE LA English DT Article ID GLASSY-WINGED SHARPSHOOTER; FLIES DIPTERA PSYCHODIDAE; SAND FLIES; SP NOV.; BACILLUS-PUMILUS; VISCERAL LEISHMANIASIS; ENTEROBACTER-SAKAZAKII; LUTZOMYIA-LONGIPALPIS; STOMOXYS-CALCITRANS; MICROBIAL DIVERSITY AB Background: Cutaneous leishmaniasis is a neglected, vector-borne parasitic disease and is responsible for persistent, often disfiguring lesions and other associated complications. Leishmania, causing zoonotic cutaneous leishmaniasis (ZCL) in the Old World are mainly transmitted by the predominant sand fly vector, Phlebotomus papatasi. To date, there is no efficient control measure or vaccine available for this widespread insect-borne infectious disease. Methodology/Principal Findings: A survey was carried out to study the abundance of different natural gut flora in P. papatasi, with the long-term goal of generating a paratransgenic sand fly that can potentially block the development of Leishmania in the sand fly gut, thereby preventing transmission of leishmania in endemic disease foci. Sand flies, in particular, P. papatasi were captured from different habitats of various parts of the world. Gut microbes were cultured and identified using 16S ribosomal DNA analysis and a phylogenetic tree was constructed. We found variation in the species and abundance of gut flora in flies collected from different habitats. However, a few Gram-positive, nonpathogenic bacteria including Bacillus flexus and B. pumilus were common in most of the sites examined. Conclusion/Significance: Our results indicate that there is a wide range of variation of aerobic gut flora inhabiting sand fly guts, which possibly reflect the ecological condition of the habitat where the fly breeds. Also, some species of bacteria (B. pumilus, and B. flexus) were found from most of the habitats. Important from an applied perspective of dissemination, our results support a link between oviposition induction and adult gut flora. C1 [Mukhopadhyay, Jaba; Rowton, Edgar D.; Ghosh, Kashinath] Walter Reed Army Inst Res, Div Entomol, Silver Spring, MD USA. [Ghosh, Kashinath] Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD USA. [Braig, Henk R.] Bangor Univ, Sch Biol Sci, Bangor, Gwynedd, Wales. RP Mukhopadhyay, J (reprint author), Walter Reed Army Inst Res, Div Entomol, Silver Spring, MD USA. EM Kashinath.ghosh@us.army.mil RI Braig, Henk/I-5477-2013 OI Braig, Henk/0000-0001-9592-1141 FU Department of Defense through the In-House Laboratory Independent Research program at the Walter Reed Army Institute of Research FX This study was funded by the Department of Defense through the In-House Laboratory Independent Research program at the Walter Reed Army Institute of Research. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 131 TC 12 Z9 12 U1 1 U2 14 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD MAY 22 PY 2012 VL 7 IS 5 AR e35748 DI 10.1371/journal.pone.0035748 PG 10 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 959VQ UT WOS:000305345300003 PM 22629302 ER PT J AU Jones, JL AF Jones, Jerry L. TI THEY "LIKE" OUR FACEBOOK STORY SO FORTUNE LA English DT Letter C1 USA, Frederick, MD USA. RP Jones, JL (reprint author), USA, Frederick, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU TIME INC PI NEW YORK PA TIME & LIFE BUILDING ROCKEFELLER CENTER, NEW YORK, NY 10020-1393 USA SN 0015-8259 J9 FORTUNE JI Fortune PD MAY 21 PY 2012 VL 165 IS 7 BP 18 EP 18 PG 1 WC Business SC Business & Economics GA 063EK UT WOS:000312978800007 ER PT J AU Reaves, EJ Salmon-Mulanovich, G Guevara, C Kochel, TJ Steinbach, TJ Bentzel, DE Montgomery, JM AF Reaves, Erik J. Salmon-Mulanovich, Gabriela Guevara, Carolina Kochel, Tadeusz J. Steinbach, Thomas J. Bentzel, David E. Montgomery, Joel M. TI Susceptibility and lack of evidence for a viremic state of rabies in the night owl monkey, Aotus nancymaae SO VIROLOGY JOURNAL LA English DT Article DE Rabies; Rhabdovirus; Lyssavirus; Incubation period; Viremia; Monkey; Aotus nancymaae; Non-human Primate; Ante mortem; Vaccine ID CENTRAL-NERVOUS-SYSTEM; IMMUNE-RESPONSE; VIRUS-INFECTION; CEBUS-APELLA; DIAGNOSIS; BATS; EXPOSURE; ANTIBODY; AMERICA; DISEASE AB Background: Rabies causes an acute fatal encephalomyelitis in most mammals following infection with rhabdovirus of the genus Lyssavirus. Little is known about rabies virus infection in species of New World non-human Primates (NHP). To investigate the suitability of the owl monkey Aotus nancymaae asissue sections examined were unremarkable for inflammation or other histologic signs of rabies a viable animal model for rabies virus candidate vaccine testing, we used clinical presentation, serology, viral isolation, and PCR to evaluate the incubation period, immunity, and pathogenesis of infected animals. We tested the hypothesis that no viremic state exists for rabies virus. Methods: Eight monkeys divided into two equal groups were inoculated intramuscularly either in the neck or footpad with 10(5) pfu of rabies virus (Pasteur/V-13R) and observed for >130 days. Oral and blood samples were collected and analyzed. Results: Two monkeys inoculated in the neck displayed classic paralytic rabies. The mean incubation period was 11.5 days. The average maximum IgG response (antibody titer >0.200 O.D.) was achieved at day 10.0 and 62.3 in the clinical rabies and non-clinical rabies cases, respectively (p = 0.0429). No difference in IgM or IgG time to seroconversion or average maximum IgM level was observed between neck versus footpad inoculation groups. No viremia or viral shedding was detected by PCR or viral isolation during the observation period, including within the two symptomatic animals three days after disease onset. Tissue sections examined were unremarkable for inflammation or other histologic signs of rabies within the asymptomatic animal. Similarly none of the brain sections exhibited immunoreactivity for rabies virus antibody. Discussion: This study demonstrates there is no difference in time to immune response between inoculation sites and distance to the brain; however, immune response tends to be more rapid in cases of clinically apparent disease and prolonged in cases infected at sites further from the brain. Conclusions: Our findings support the hypothesis that a viremic state for rabies does not exist in the New World Monkey, Aotus nancymaae, and it appears that this species may be refractory to infection. The species does provide a suitable model to assess post infection immune responses. Additional studies that address the limitations of sample size, length of observation, and lack of measurable infection should be conducted. C1 [Steinbach, Thomas J.] Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. EM ztq9@cdc.gov FU Department of Defense Global Emerging Infectious Surveillance and Response Program [847705 82000 25 GB B0016] FX We are uniformed service members or an employee of the U.S. Government and this work was done as part of our official duties. Title 17 U.S.C. 105 provides that 'Copyright protection under this title is not available for any work of the United States Government.' Title 17 U.S.C.} 101 defines a U.S. Government work as a work prepared by a military service member or employee of the U.S. Government as part of that person's official duties. The views expressed in this article are those of the authors and do not necessarily reflect the official policy or position of the Department of the Navy, Department of Defense, nor the U.S. Government. This work wasfunded by the Department of Defense Global Emerging Infectious Surveillance and Response Program, grant 847705 82000 25 GB B0016. NR 39 TC 2 Z9 2 U1 0 U2 8 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1743-422X J9 VIROL J JI Virol. J. PD MAY 21 PY 2012 VL 9 AR 95 DI 10.1186/1743-422X-9-95 PG 9 WC Virology SC Virology GA 060YX UT WOS:000312815400001 PM 22612895 ER PT J AU Hooper, JB Starovoytov, ON Borodin, O Bedrov, D Smith, GD AF Hooper, Justin B. Starovoytov, Oleg N. Borodin, Oleg Bedrov, Dmitry Smith, Grant D. TI Molecular dynamics simulation studies of the influence of imidazolium structure on the properties of imidazolium/azide ionic liquids SO JOURNAL OF CHEMICAL PHYSICS LA English DT Article ID PHYSICOCHEMICAL PROPERTIES; CATION; CHAIN AB Atomistic molecular dynamics simulations were performed on 1-butyl-3-methyl-imidazolium azide [bmim][N-3], 1-butyl-2,3-dimethylimidazolium azide [bmmim][N-3], and 1-butyny1-3-methylimidazolium azide [bumim][N-3] ionic liquids. The many-body polarizable APPLE&P force field was augmented with parameters for the azide anion and the bumim cation. Good agreement between the experimentally determined and simulated crystal structure of [bumim][N-3] as well as the liquid-state density and ionic conductivity of [bmmim][N-3] were found. Methylation of bmim (yielding bmmim) resulted in dramatic changes in ion structuring in the liquid and slowing of ion motion. Conversely, replacing the butyl group of bmim with the smaller 2-butynyl group resulted in an increase of ion dynamics (C) 2012 American Institute of Physics. [http://dx.doi.org/10.1063/1.4718800] C1 [Hooper, Justin B.; Smith, Grant D.] Wasatch Mol Inc, Salt Lake City, UT 84103 USA. [Starovoytov, Oleg N.; Bedrov, Dmitry] Univ Utah, Dept Mat Sci & Engn, Salt Lake City, UT 84112 USA. [Borodin, Oleg] USA, Electrochem Branch, Res Lab, Adelphi, MD 20783 USA. RP Hooper, JB (reprint author), Wasatch Mol Inc, 825 N 300 W Ste W003, Salt Lake City, UT 84103 USA. EM jbhooper@wasatchmolecular.com RI Borodin, Oleg/B-6855-2012 OI Borodin, Oleg/0000-0002-9428-5291 FU Air Force Office of Scientific Research, Department of the Air Force [FA9550-09-C-0110] FX The authors gratefully acknowledge financial support of this work by Air Force Office of Scientific Research, Department of the Air Force Contract No. FA9550-09-C-0110 to Wasatch Molecular Inc. An allocation of computer time from the Center for High Performance Computing at the University of Utah is also gratefully acknowledged. NR 25 TC 10 Z9 10 U1 0 U2 29 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0021-9606 J9 J CHEM PHYS JI J. Chem. Phys. PD MAY 21 PY 2012 VL 136 IS 19 AR 194506 DI 10.1063/1.4718800 PG 7 WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical SC Chemistry; Physics GA 945VC UT WOS:000304303500030 PM 22612102 ER PT J AU Kumar, M Islam, MN Terry, FL Freeman, MJ Chan, A Neelakandan, M Manzur, T AF Kumar, Malay Islam, Mohammed N. Terry, Fred L., Jr. Freeman, Michael J. Chan, Allan Neelakandan, Manickam Manzur, Tariq TI Stand-off detection of solid targets with diffuse reflection spectroscopy using a high-power mid-infrared supercontinuum source SO APPLIED OPTICS LA English DT Article ID INFRARED-ABSORPTION; DIODE; EXPLOSIVES; GENERATION; SPECTRA; ANALYTE AB We measure the diffuse reflection spectrum of solid samples such as explosives (TNT, RDX, PETN), fertilizers (ammonium nitrate, urea), and paints (automotive and military grade) at a stand-off distance of 5 m using a mid-infrared supercontinuum light source with 3.9 W average output power. The output spectrum extends from 750-4300 nm, and it is generated by nonlinear spectral broadening in a 9 m long fluoride fiber pumped by high peak power pulses from a dual-stage erbium-ytterbium fiber amplifier operating at 1543 nm. The samples are distinguished using unique spectral signatures that are attributed to the molecular vibrations of the constituents. Signal-to-noise ratio (SNR) calculations demonstrate the feasibility of increasing the stand-off distance from 5 to similar to 150 m, with a corresponding drop in SNR from 28 to 10 dB. (C) 2012 Optical Society of America C1 [Kumar, Malay; Islam, Mohammed N.; Terry, Fred L., Jr.] Univ Michigan, Dept Elect Engn & Comp Sci, Ann Arbor, MI 48109 USA. [Islam, Mohammed N.; Freeman, Michael J.] Omni Sci Inc, Dexter, MI 48130 USA. [Chan, Allan; Neelakandan, Manickam] USA, CERDEC I2WD, Aberdeen Proving Ground, MD 21005 USA. [Manzur, Tariq] DIVNPT, NUWC, Newport, RI 02841 USA. RP Kumar, M (reprint author), Univ Michigan, Dept Elect Engn & Comp Sci, 1301 Beal Ave, Ann Arbor, MI 48109 USA. EM malayk@umich.edu OI Terry, Fred/0000-0002-0634-5005 FU Omni Sciences, Inc.; U.S. Army Communications-Electronics Research, Development and Engineering Center (CERDEC) [W15P7T-10-C-H606]; Defense Advanced Research Projects Agency (DARPA); Naval Air Systems Command (NAVAIR) [PMA-272] FX We would like to thank our sponsors-Omni Sciences, Inc., the U.S. Army Communications-Electronics Research, Development and Engineering Center (CERDEC, contract no. W15P7T-10-C-H606), the Defense Advanced Research Projects Agency (DARPA), and Naval Air Systems Command (NAVAIR) PMA-272 for their support. NR 31 TC 32 Z9 33 U1 3 U2 29 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1559-128X EI 2155-3165 J9 APPL OPTICS JI Appl. Optics PD MAY 20 PY 2012 VL 51 IS 15 BP 2794 EP 2807 DI 10.1364/AO.51.002794 PG 14 WC Optics SC Optics GA 945AY UT WOS:000304246400004 PM 22614581 ER PT J AU Dabney, RS Hale, DF Vreeland, TJ Clifton, GT Sears, AK Patil, R Ponniah, S Shumway, NM Peoples, GE Mittendorf, EA AF Dabney, Raetasha Sheavette Hale, Diane F. Vreeland, Timothy J. Clifton, Guy T. Sears, Alan K. Patil, Ritesh Ponniah, Sathibalan Shumway, Nathan M. Peoples, George Earl Mittendorf, Elizabeth Ann TI Safety and long-term maintenance of anti-HER2 immunity following booster inoculations of the E75 breast cancer vaccine. SO JOURNAL OF CLINICAL ONCOLOGY LA English DT Meeting Abstract CT 48th Annual Meeting of the American-Society-of-Clinical-Oncology (ASCO) CY JUN 01-06, 2012 CL Chicago, IL SP Amer Soc Clin Oncol (ASCO) C1 Brooke Army Med Ctr, San Antonio, TX USA. Brooke Army Med Ctr, Dept Surg, Ft Sam Houston, TX 78234 USA. Roswell Pk Canc Inst, Buffalo, NY 14263 USA. USUHS, Canc Vaccine Dev Program, US Mil Canc Inst, Bethesda, MD USA. San Antonio Mil Med Ctr, Ft Sam Houston, TX USA. Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC CLINICAL ONCOLOGY PI ALEXANDRIA PA 2318 MILL ROAD, STE 800, ALEXANDRIA, VA 22314 USA SN 0732-183X J9 J CLIN ONCOL JI J. Clin. Oncol. PD MAY 20 PY 2012 VL 30 IS 15 SU S MA 2529 PG 1 WC Oncology SC Oncology GA 131QQ UT WOS:000318009801836 ER PT J AU Hale, DF Perez, SA Vreeland, TJ Trappey, AF Dabney, RS Berry, JS Ardavanis, A Sears, AK Papamichail, M Clifton, GT Pappou, E Patil, R Anastasopoulou, E Ponniah, S Shumway, NM Peoples, GE Mittendorf, EA AF Hale, Diane F. Perez, Sonia A. Vreeland, Timothy J. Trappey, Alfred F. Dabney, Raetasha Sheavette Berry, John S. Ardavanis, Alexandros Sears, Alan K. Papamichail, Michael Clifton, Guy T. Pappou, Efi Patil, Ritesh Anastasopoulou, Eleftheria Ponniah, Sathibalan Shumway, Nathan M. Peoples, George Earl Mittendorf, Elizabeth Ann TI An assessment of disease features and immune response in breast cancer patients that did not recur after receiving HER2 peptide, AE37 vaccine in a randomized phase II trial. SO JOURNAL OF CLINICAL ONCOLOGY LA English DT Meeting Abstract CT 48th Annual Meeting of the American-Society-of-Clinical-Oncology (ASCO) CY JUN 01-06, 2012 CL Chicago, IL SP Amer Soc Clin Oncol (ASCO) C1 Brooke Army Med Ctr, San Antonio, TX USA. St Savvas Canc Hosp, CIIC, Athens, Greece. St Savvas Anticanc Hosp, Dept Med Oncol 1, Athens, Greece. Brooke Army Med Ctr, Dept Surg, Ft Sam Houston, TX 78234 USA. Roswell Pk Canc Inst, Buffalo, NY 14263 USA. United States Mil Canc Inst, Canc Vaccine Dev Program, USUHS, Bethesda, MD USA. SAMMC, Ft Sam Houston, TX USA. Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA. NR 0 TC 0 Z9 0 U1 0 U2 4 PU AMER SOC CLINICAL ONCOLOGY PI ALEXANDRIA PA 2318 MILL ROAD, STE 800, ALEXANDRIA, VA 22314 USA SN 0732-183X J9 J CLIN ONCOL JI J. Clin. Oncol. PD MAY 20 PY 2012 VL 30 IS 15 SU S MA 625 PG 1 WC Oncology SC Oncology GA 131QQ UT WOS:000318009800134 ER PT J AU Vreeland, TJ Hale, DF Sears, AK Clifton, GT Pappou, E Dabney, RS Ardavanis, A Patil, R Ponniah, S Anastasopoulou, E Perez, SA Shumway, NM Peoples, GE Mittendorf, EA AF Vreeland, Timothy J. Hale, Diane F. Sears, Alan K. Clifton, Guy T. Pappou, Efi Dabney, Raetasha Sheavette Ardavanis, Alexandros Patil, Ritesh Ponniah, Sathibalan Anastasopoulou, Eleftheria Perez, Sonia A. Shumway, Nathan M. Peoples, George Earl Mittendorf, Elizabeth Ann TI From bench to bedside: The use of the li-Key technology to improve helper peptides for clinical use in cancer vaccines. SO JOURNAL OF CLINICAL ONCOLOGY LA English DT Meeting Abstract CT 48th Annual Meeting of the American-Society-of-Clinical-Oncology (ASCO) CY JUN 01-06, 2012 CL Chicago, IL SP Amer Soc Clin Oncol (ASCO) C1 San Antonio Mil Med Ctr, Ft Sam Houston, TX USA. Brooke Army Med Ctr, San Antonio, TX USA. San Antonio Mil Med Ctr, Dept Gen Surg, Ft Sam Houston, TX USA. St Savvas Canc Hosp, CIIC, Athens, Greece. Anticanc Hosp, Dept Med Oncol 1, Athens, Greece. Roswell Pk Canc Inst, Buffalo, NY 14263 USA. USUHS, Canc Vaccine Dev Program, US Mil Canc Inst, Bethesda, MD USA. Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC CLINICAL ONCOLOGY PI ALEXANDRIA PA 2318 MILL ROAD, STE 800, ALEXANDRIA, VA 22314 USA SN 0732-183X J9 J CLIN ONCOL JI J. Clin. Oncol. PD MAY 20 PY 2012 VL 30 IS 15 SU S MA 2508 PG 1 WC Oncology SC Oncology GA 131QQ UT WOS:000318009802126 ER PT J AU Mendoza, D Johnson, SA Peterson, BA Natarajan, V Salgado, M Dewar, RL Burbelo, PD Doria-Rose, NA Graf, EH Greenwald, JH Hodge, JN Thompson, WL Cogliano, NA Chairez, CL Rehm, CA Jones, S Hallahan, CW Kovacs, JA Sereti, I Sued, O Peel, SA O'Connell, RJ O'Doherty, U Chun, TW Connors, M Migueles, SA AF Mendoza, Daniel Johnson, Sarah A. Peterson, Bennett A. Natarajan, Ven Salgado, Maria Dewar, Robin L. Burbelo, Peter D. Doria-Rose, Nicole A. Graf, Erin H. Greenwald, Jamieson H. Hodge, Jessica N. Thompson, William L. Cogliano, Nancy A. Chairez, Cheryl L. Rehm, Catherine A. Jones, Sara Hallahan, Claire W. Kovacs, Joseph A. Sereti, Irini Sued, Omar Peel, Sheila A. O'Connell, Robert J. O'Doherty, Una Chun, Tae-Wook Connors, Mark Migueles, Stephen A. TI Comprehensive analysis of unique cases with extraordinary control over HIV replication SO BLOOD LA English DT Article ID HUMAN-IMMUNODEFICIENCY-VIRUS; CD4(+) T-CELLS; ACTIVE ANTIRETROVIRAL THERAPY; LONG-TERM NONPROGRESSORS; LOW-LEVEL VIREMIA; ELITE SUPPRESSORS; VIRAL REPLICATION; IMMUNE CONTROL; HIV-1-INFECTED PATIENTS; EX-VIVO AB True long-term nonprogressors (LTNPs)/elite controllers (ECs) maintain durable control over HIV replication without anti-retroviral therapy. Herein we describe 4 unique persons who were distinct from conventional LTNPs/ECs in that they had extraordinarily low HIV burdens and comparatively weak immune responses. As a group, typical LTNPs/ECs have unequivocally reactive HIV-1 Western blots, viral loads below the lower threshold of clinical assays, low levels of persistent viral reservoirs, an over-representation of protective HLA alleles, and robust HIV-specific CD8(+) T-cell responses. The 4 unique cases were distinguished from typical LTNPs/ECs based on weakly reactive Western blots, undetectable plasma viremia by a single copy assay, extremely low to undetectable HIV DNA levels, and difficult to isolate replication-competent virus. All 4 had at least one protective HLAallele and CD8(+) T-cell responses that were disproportionately high for the low antigen levels but comparatively lower than those of typical LTNPs/ECs. These unique persons exhibit extraordinary suppression over HIV replication, therefore, higher-level control than has been demonstrated in previous studies of LTNPs/ECs. Additional insight into the full spectrum of immune-mediated suppression over HIV replication may enhance our understanding of the associated mechanisms, which should inform the design of efficacious HIV vaccines and immunotherapies. (Blood. 2012; 119(20): 4645-4655) C1 [Migueles, Stephen A.] NIAID, HIV Specif Immun Sect, Immunoregulat Lab, NIH, Bethesda, MD 20892 USA. [Natarajan, Ven; Dewar, Robin L.; Jones, Sara] Sci Applicat Int Corp Frederick Inc, Frederick, MD USA. [Salgado, Maria] Johns Hopkins Univ, Sch Med, Dept Med, Baltimore, MD 21205 USA. [Salgado, Maria] Univ Autonoma Barcelona, Hosp Univ Germans Trias & Pujol, Inst Recerca SIDA, IrsiCaixa, Badalona, Spain. [Burbelo, Peter D.] Natl Inst Dent & Craniofacial Res, Lab Sensory Biol, NIH, Bethesda, MD USA. [Graf, Erin H.; O'Doherty, Una] Univ Penn, Sch Med, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA. [Hallahan, Claire W.] NIAID, Biostat Res Branch, NIH, Bethesda, MD 20892 USA. [Kovacs, Joseph A.] NIH, Dept Crit Care Med, Bethesda, MD 20892 USA. [Sued, Omar] Fdn Huesped, Buenos Aires, DF, Argentina. [Peel, Sheila A.; O'Connell, Robert J.] Walter Reed Army Inst Res, Silver Spring, MD USA. RP Migueles, SA (reprint author), NIAID, HIV Specif Immun Sect, Immunoregulat Lab, NIH, 10 Ctr Dr,Bldg 10,Rm 11B-07, Bethesda, MD 20892 USA. EM smigueles@niaid.nih.gov RI Salgado, Maria /G-3462-2016; OI Mendoza, Daniel/0000-0002-6362-0771; Sued, Omar/0000-0001-5818-770X FU Intramural Research Program of NIAID; Intramural Research Program of National Institute of Dental and Craniofacial Research (NIDCR); NIAID [HHSN261200800001E] FX This work was supported in part by the Intramural Research Programs of NIAID and National Institute of Dental and Craniofacial Research (NIDCR) and (NIAID contract HHSN261200800001E; V.N., R.L.D., and S.J.). NR 53 TC 25 Z9 26 U1 0 U2 0 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD MAY 17 PY 2012 VL 119 IS 20 BP 4645 EP 4655 DI 10.1182/blood-2011-10-381996 PG 11 WC Hematology SC Hematology GA 959CM UT WOS:000305288400013 PM 22490332 ER PT J AU Tucker, CJ Wilken, JM Stinner, DJ Kirk, KL AF Tucker, Christopher J. Wilken, Jason M. Stinner, Daniel J. Kirk, Kevin L. TI A Comparison of Limb-Socket Kinematics of Bone-Bridging and Non-Bone-Bridging Wartime Transtibial Amputations SO JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME LA English DT Article ID TRANS-FEMORAL SOCKET; RESIDUAL FEMUR; MOTION; GAIT; REHABILITATION; ULTRASOUND AB Background: While there are proponents of both bone-bridging and non-bone-bridging transtibial amputation techniques, there is a lack of evidence describing functional differences between these two techniques. The goal of the present investigation was to objectively compare the techniques of bone-bridging and non-bone-bridging with respect to limb socket displacement during physiologic loading. Methods: Fifteen male subjects with an average age of twenty-seven years (range, twenty-two to thirty-two years) who had undergone a unilateral transtibial amputation secondary to a traumatic wartime injury were prospectively evaluated. Seven patients had undergone a bone-bridging amputation, and eight had undergone a non-bone-bridging amputation. Digital fluoroscopic video was used to measure the vertical displacement of the limb within a total-surface-bearing socket with weight-bearing from 0% to 100% of body weight. Results: There was no difference in limb-socket displacement between amputation techniques with initial loading (12.78 mm for the bone-bridging group, compared with 12.43 mm for the non-bone-bridging group; p = 0.88) or with total loading (p = 0.98). Similarly, there was no difference between suspension mechanisms in limb-socket displacement with initial loading (12.15 mm for patients with pin lock suspension, compared with 12.98 mm for those with suction sleeve suspension; p = 0.72) or with total loading (18.24 mm for patients with pin lock suspension, compared with 21.42 mm for those with suction sleeve suspension, p = 0.21). Conclusions: The current study demonstrated no difference between surgical techniques with respect to bone-socket displacement. These data provide no evidence to support statements that bone-bridging contributes to a more efficient platform in the total-surface-bearing socket. C1 [Tucker, Christopher J.; Wilken, Jason M.; Stinner, Daniel J.; Kirk, Kevin L.] Brooke Army Med Ctr, Ctr Intrepid, Ft Sam Houston, TX 78234 USA. RP Tucker, CJ (reprint author), Brooke Army Med Ctr, Dept Orthoped & Rehabil, 3851 Rogers Brooke Dr, Ft Sam Houston, TX 78234 USA. EM daniel.stinner@amedd.army.mil OI Wilken, Jason/0000-0002-5556-7667 NR 16 TC 6 Z9 6 U1 0 U2 0 PU JOURNAL BONE JOINT SURGERY INC PI NEEDHAM PA 20 PICKERING ST, NEEDHAM, MA 02192 USA SN 0021-9355 J9 J BONE JOINT SURG AM JI J. Bone Joint Surg.-Am. Vol. PD MAY 16 PY 2012 VL 94A IS 10 BP 924 EP 930 DI 10.2106/JBJS.K.00605 PG 7 WC Orthopedics; Surgery SC Orthopedics; Surgery GA 945OB UT WOS:000304284800010 PM 22617921 ER PT J AU Simons-Morton, BG Zhang, ZW Jackson, JC Albert, PS AF Simons-Morton, Bruce G. Zhang, Zhiwei Jackson, John C. Albert, Paul S. TI Do Elevated Gravitational-Force Events While Driving Predict Crashes and Near Crashes? SO AMERICAN JOURNAL OF EPIDEMIOLOGY LA English DT Article DE accident prevention; adolescent behavior; area under the curve; motor vehicle crashes; prediction; receiver operating characteristic; risk-taking; safety ID DRIVERS; MODELS; RISK AB The purpose of this research was to determine the extent to which elevated gravitational-force event rates predict crashes and near crashes. Accelerometers, global positioning systems, cameras, and other technology were installed in vehicles driven by 42 newly licensed Virginia teenage drivers for a period of 18 months between 2006 and 2009. Elevated gravitational force and crash and near-crash events were identified, and rates per miles driven were calculated. (One mile = 1.6 km.) The correlation between crashes and near crashes and elevated gravitational-force event rates was 0.60. Analyses were done by using generalized estimating equations with logistic regression. Higher elevated gravitational-force event rates in the past month substantially increased the risk of a crash in the subsequent month (odds ratio = 1.07, 95% confidence interval: 1.02, 1.12). Although the difference in this relation did not vary significantly by time, it was highest in the first 6 months compared with the second and third 6-month periods. With a receiver operating characteristic curve, the risk models showed relatively high predictive accuracy with an area under the curve of 0.76. The authors conclude that elevated gravitational-force event rates can be used to assess risk and to show high predictive accuracy of a near-future crash. C1 [Simons-Morton, Bruce G.; Zhang, Zhiwei; Albert, Paul S.] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Div Epidemiol Stat & Prevent Res, Rockville, MD USA. [Jackson, John C.] US Mil Acad, Dept Math Sci, West Point, NY 10996 USA. RP Simons-Morton, BG (reprint author), Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Prevent Res Branch, Div Epidemiol Stat & Prevent Res, 6100 Execut Blvd,Room 7B13M, Bethesda, MD 20892 USA. EM mortonb@mail.nih.gov OI Simons-Morton, Bruce/0000-0003-1099-6617 FU National Institutes of Health [N01-HD-5-3405] FX This research was supported by the Intramural Research Program of the National Institutes of Health (contract N01-HD-5-3405). NR 13 TC 14 Z9 14 U1 0 U2 7 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0002-9262 J9 AM J EPIDEMIOL JI Am. J. Epidemiol. PD MAY 15 PY 2012 VL 175 IS 10 BP 1075 EP 1079 DI 10.1093/aje/kwr440 PG 5 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 944KC UT WOS:000304199000013 PM 22271924 ER PT J AU Crum-Cianflone, NF Roediger, MP Moore, DJ Hale, B Weintrob, A Ganesan, A Eberly, LE Johnson, E Agan, BK Letendre, S AF Crum-Cianflone, Nancy F. Roediger, Mollie Poehlman Moore, David J. Hale, Braden Weintrob, Amy Ganesan, Anuradha Eberly, Lynn E. Johnson, Erica Agan, Brian K. Letendre, Scott TI Prevalence and Factors Associated With Sleep Disturbances Among Early-Treated HIV-Infected Persons SO CLINICAL INFECTIOUS DISEASES LA English DT Article ID INSOMNIA; EFAVIRENZ; QUALITY; DISORDERS; MANAGEMENT; ETRAVIRINE; THERAPY; ADULTS; MEN AB Background. Sleep disturbances are reportedly common among persons infected with human immunodeficiency virus (HIV), but recent data, including comparisons with HIV-uninfected persons, are limited. Methods. We performed a cross-sectional study among early-treated HIV-infected military beneficiaries (n = 193) to determine the prevalence and factors associated with insomnia (Pittsburgh Sleep Quality Index [PSQI]) and daytime sleepiness (Epworth Sleepiness Scale [ESS]). Data were compared with HIV-uninfected persons (n = 50) matched by age, sex, race or ethnicity, and military rank. Results. Forty-six percent of HIV-infected persons had insomnia (PSQI >5), and 30% reported daytime drowsiness (ESS >= 10). The prevalence of insomnia and daytime sleepiness was not significantly higher compared with the HIV-uninfected group (38% [P = .30] and 20% [P = .18], respectively). In the multivariate model, factors associated with insomnia among HIV infected patients included depression (odds ratio [OR], 16.8; 95% confidence interval [CI], 2.0-142.1; P = .01), increased waist size (OR, 2.7; 95% CI, 1.4-5.1; P = .002), and fewer years of education (OR, 0.8; 95% CI, .7-.95; P = .006). Neurocognitive impairment (diagnosed in 19% of HIV-infected participants) was not associated with insomnia; however, HIV-infected persons with insomnia were 3.1-fold more likely to have a decline in activities of daily living than those without insomnia (23% vs 9%; P = .01). Only 18% of HIV-infected persons reported using a sleep medication at least weekly. Conclusions. HIV-infected persons have a high prevalence of insomnia, but among an early-treated cohort this rate was not significantly higher compared with HIV-uninfected persons. Factors associated with insomnia among HIV-infected patients include depression and increased waist size. Prompt diagnosis and treatment of sleep disturbances are advocated and may improve quality of life. C1 [Crum-Cianflone, Nancy F.] Naval Med Ctr San Diego, Clin Invest Dept KCA, Div Infect Dis, HIV Clin, San Diego, CA 92134 USA. [Crum-Cianflone, Nancy F.; Roediger, Mollie Poehlman; Hale, Braden; Weintrob, Amy; Ganesan, Anuradha; Eberly, Lynn E.; Johnson, Erica; Agan, Brian K.] Uniformed Serv Univ Hlth Sci, Infect Dis Clin Res Program, Bethesda, MD 20814 USA. [Ganesan, Anuradha] Natl Naval Med Ctr, Infect Dis Clin, Bethesda, MD USA. [Crum-Cianflone, Nancy F.; Hale, Braden] Naval Hlth Res Ctr, San Diego, CA USA. [Moore, David J.; Letendre, Scott] Univ Calif San Diego, HIV Neurobehav Res Program, San Diego, CA 92103 USA. [Roediger, Mollie Poehlman; Eberly, Lynn E.] Univ Minnesota, Div Biostat, Minneapolis, MN USA. [Weintrob, Amy] Walter Reed Army Med Ctr, Infect Dis Clin, Washington, DC USA. [Johnson, Erica] San Antonio Mil Med Ctr, Infect Dis Serv, San Antonio, TX USA. RP Crum-Cianflone, NF (reprint author), Naval Med Ctr San Diego, Clin Invest Dept KCA, Div Infect Dis, HIV Clin, 34800 Bob Wilson Dr,Ste 5, San Diego, CA 92134 USA. EM nancy.crum@med.navy.mil OI Eberly, Lynn/0000-0003-4763-330X; Agan, Brian/0000-0002-5114-1669 FU Department of Defense through Uniformed Services University of the Health Sciences [HU0001-05-2-0011]; National Institute of Allergy and Infectious Diseases, National Institutes of Health [Y1-AI-5072]; National Institute of Mental Health [P30 MH62512] FX This work was supported by the Infectious Disease Clinical Research Program, a Department of Defense program executed through the Uniformed Services University of the Health Sciences (grant number HU0001-05-2-0011). This project has been funded in whole, or in part, with federal funds from the National Institute of Allergy and Infectious Diseases, National Institutes of Health, under Inter-Agency Agreement Y1-AI-5072. Support was also obtained from the National Institute of Mental Health (grant P30 MH62512 to UCSD HIV Neurobehavioral Research Center). NR 37 TC 13 Z9 13 U1 0 U2 7 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 1058-4838 J9 CLIN INFECT DIS JI Clin. Infect. Dis. PD MAY 15 PY 2012 VL 54 IS 10 BP 1485 EP 1494 DI 10.1093/cid/cis192 PG 10 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 942MW UT WOS:000304049300022 PM 22431801 ER PT J AU Ciraci, C Poutrina, E Scalora, M Smith, DR AF Ciraci, Cristian Poutrina, Ekaterina Scalora, Michael Smith, David R. TI Origin of second-harmonic generation enhancement in optical split-ring resonators SO PHYSICAL REVIEW B LA English DT Article ID MAGNETIC METAMATERIALS; METAL-SURFACES AB We present a study of the second-order nonlinear optical properties of metal-based metamaterials. A hydrodynamic model for electronic response is used, in which nonlinear surface contributions are expressed in terms of the bulk polarization. The model is in good agreement with published experimental results, and clarifies the mechanisms contributing to the nonlinear response. In particular, we show that the reported enhancement of the second harmonic in split-ring resonator based media is driven by the electric rather than the magnetic properties of the structure. C1 [Ciraci, Cristian; Poutrina, Ekaterina; Smith, David R.] Duke Univ, Ctr Metamat & Integrated Plasmon, Durham, NC 27708 USA. [Scalora, Michael] USA, CM Bowden Res Facil, Res Dev & Engn Command RDECOM, Redstone Arsenal, AL 35803 USA. RP Ciraci, C (reprint author), Duke Univ, Ctr Metamat & Integrated Plasmon, Durham, NC 27708 USA. EM cristian.ciraci@duke.edu RI Smith, David/E-4710-2012 FU Air Force Office of Scientific Research (AFOSR) [FA9550-09-1-0562] FX The authors would like to thank Yaroslav Urzhumov for valuable discussions. This work was supported by the Air Force Office of Scientific Research (AFOSR, Grant No. FA9550-09-1-0562). NR 28 TC 45 Z9 45 U1 3 U2 29 PU AMER PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 1098-0121 J9 PHYS REV B JI Phys. Rev. B PD MAY 15 PY 2012 VL 85 IS 20 AR 201403 DI 10.1103/PhysRevB.85.201403 PG 5 WC Physics, Condensed Matter SC Physics GA 942WN UT WOS:000304082100003 ER PT J AU de Souza, MS Ratto-Kim, S Chuenarom, W Schuetz, A Chantakulkij, S Nuntapinit, B Valencia-Micolta, A Thelian, D Nitayaphan, S Pitisuttithum, P Paris, RM Kaewkungwal, J Michael, NL Rerks-Ngarm, S Mathieson, B Marovich, M Currier, JR Kim, JH AF de Souza, Mark S. Ratto-Kim, Silvia Chuenarom, Weerawan Schuetz, Alexandra Chantakulkij, Somsak Nuntapinit, Bessara Valencia-Micolta, Anais Thelian, Doris Nitayaphan, Sorachai Pitisuttithum, Punnee Paris, Robert M. Kaewkungwal, Jaranit Michael, Nelson L. Rerks-Ngarm, Supachai Mathieson, Bonnie Marovich, Mary Currier, Jeffrey R. Kim, Jerome H. CA Minist Publ Hlth Thai AIDS Vaccine TI The Thai Phase III Trial (RV144) Vaccine Regimen Induces T Cell Responses That Preferentially Target Epitopes within the V2 Region of HIV-1 Envelope SO JOURNAL OF IMMUNOLOGY LA English DT Article ID HUMAN-IMMUNODEFICIENCY-VIRUS; BOOST VACCINE; VIRAL LOAD; INTEGRIN ALPHA(4)BETA(7); SIMIAN IMMUNODEFICIENCY; IMMUNODOMINANT REGIONS; FUNCTIONAL SIGNATURES; LYMPHOCYTE RESPONSES; PROTECTIVE VACCINE; EFFECTOR FUNCTIONS AB The Thai HIV phase HI prime/boost vaccine trial (RV144) using ALVAC-HIV (vCP1521) and AIDS VAX B/E was, to our knowledge, the first to demonstrate acquisition efficacy. Vaccine-induced, cell-mediated immune responses were assessed. T cell epitope mapping studies using IFN-gamma ELISPOT was performed on PBMCs from HIV-1 uninfected vaccine (n = 61) and placebo (n = 10) recipients using HIV-1 Env peptides. Positive responses were measured in 25 (41%) vaccinees and were predominantly CD4(+) T cell-mediated. Responses were targeted within the HIV Env region, with 15 of 25 (60%) of vaccinees recognizing peptides derived from the V2 region of HIV-1 Env, which includes the alpha(4)beta(7) integrin binding site. Intracellular cytokine staining confirmed that Env responses predominated (19 of 30; 63% of vaccine recipients) and were mediated by polyfunctional effector memory CD4(+) T cells, with the majority of responders producing both IL-2 and IFN-gamma (12 of 19; 63%). HIV Env Ab titers were higher in subjects with IL-2 compared with those without IL-2 secreting HIV Env-specific effector memory T cells. Proliferation assays revealed that HIV Ag-specific T cells were CD4(+), with the majority (80%) expressing CD107a. HIV-specific T cell lines obtained from vaccine recipients confirmed V2 specificity, polyfunctionality, and functional cytolytic capacity. Although the RV144 T cell responses were modest in frequency compared with humoral immune responses, the CD4(+) T cell response was directed to HIV-1 Env and more particularly the V2 region. The Journal of Immunology, 2012, 188: 5166-5176. C1 [de Souza, Mark S.; Chuenarom, Weerawan; Schuetz, Alexandra; Chantakulkij, Somsak; Nuntapinit, Bessara] Armed Forces Res Inst Med Sci, US Mil HIV Res Program, US Army Med Component, Bangkok 10400, Thailand. [de Souza, Mark S.; Ratto-Kim, Silvia; Schuetz, Alexandra; Valencia-Micolta, Anais; Thelian, Doris; Paris, Robert M.; Michael, Nelson L.; Marovich, Mary; Currier, Jeffrey R.; Kim, Jerome H.] Walter Reed Army Med Ctr, US Mil HIV Res Program, Div Retrovirol, Rockville, MD 20850 USA. [Pitisuttithum, Punnee] Mahidol Univ, Fac Trop Med, Vaccine Trials Ctr, Bangkok 10400, Thailand. [Kaewkungwal, Jaranit] Mahidol Univ, Fac Trop Med, Ctr Excellence Biomed & Publ Hlth Informat, Bangkok 10400, Thailand. [Rerks-Ngarm, Supachai] Minist Publ Hlth, Dept Dis Control, Nonthaburi 11000, Thailand. [Mathieson, Bonnie] NIH, Off AIDS Res, Bethesda, MD 20892 USA. RP de Souza, MS (reprint author), Armed Forces Res Inst Med Sci, US Mil HIV Res Program, US Army Med Component, 315-6 Rajvithi Rd, Bangkok 10400, Thailand. EM desouzams@afrims.org FU U.S. Army Medical Research and Materiel Command [Y1-AI-2642-12]; National Institute of Allergy and Infectious Diseases [Y1-AI-2642-12]; Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. [W81XWH-07-2-0067]; U.S. Department of Defense [W81XWH-07-2-0067] FX This work was supported in part by Interagency Agreement Y1-AI-2642-12 between the U.S. Army Medical Research and Materiel Command and the National Institute of Allergy and Infectious Diseases. In addition, this work was supported by a cooperative agreement (W81XWH-07-2-0067) between the Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., and the U.S. Department of Defense. Portions of this work were presented at the AIDS Vaccine Meeting 2009, October 19-22, 2009, Paris, France (Abstract OA07-04LB); the 2010 Keystone Symposium "HIV Vaccines/Viral Immunity", March 21-26, 2010, Banff, Alberta, Canada (Abstract X5 159); the 4th Vaccine and ISV Annual Global Congress, October 3-5, 2010, Vienna, Austria (Abstract O2.1); and the Europrise: Rational Design of HIV Vaccines and Microbicides Network Annual Conference, November 15-18, 2010, Lisbon, Portugal. NR 58 TC 81 Z9 81 U1 2 U2 9 PU AMER ASSOC IMMUNOLOGISTS PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 0022-1767 J9 J IMMUNOL JI J. Immunol. PD MAY 15 PY 2012 VL 188 IS 10 BP 5166 EP 5176 DI 10.4049/jimmunol.1102756 PG 11 WC Immunology SC Immunology GA 937BP UT WOS:000303634300050 PM 22529301 ER PT J AU Posse, S Ackley, E Mutihac, R Rick, J Shane, M Murray-Krezan, C Zaitsev, M Speck, O AF Posse, Stefan Ackley, Elena Mutihac, Radu Rick, Jochen Shane, Matthew Murray-Krezan, Cristina Zaitsev, Maxim Speck, Oliver TI Enhancement of temporal resolution and BOLD sensitivity in real-time fMRI using multi-slab echo-volumar imaging SO NEUROIMAGE LA English DT Article DE fMRI; Echo-volumar imaging; Real-time; Temporal resolution; BOLD sensitivity; Physiological noise; Event related; Resting state networks ID TO-NOISE RATIO; FUNCTIONAL MRI; PHYSIOLOGICAL NOISE; HUMAN BRAIN; NMR; RECONSTRUCTION; OPTIMIZATION; DISTORTION; MOTION; LONG AB In this study, a new approach to high-speed fMRI using multi-slab echo-volumar imaging (EVI) is developed that minimizes geometrical image distortion and spatial blurring, and enables nonaliased sampling of physiological signal fluctuation to increase BOLD sensitivity compared to conventional echo-planar imaging (EPI). Real-time fMRI using whole brain 4-slab EVI with 286 ms temporal resolution (4 mm isotropic voxel size) and partial brain 2-slab EVI with 136 ms temporal resolution (4 x 4 x 6 mm(3) voxel size) was performed on a clinical 3 Tesla MRI scanner equipped with 12-channel head coil. Four-slab EVI of visual and motor tasks significantly increased mean (visual: 96%, motor: 66%) and maximum t-score (visual: 263%, motor: 124%) and mean (visual: 59%, motor: 131%) and maximum (visual: 29%, motor: 67%) BOLD signal amplitude compared with EPI. Time domain moving average filtering (2s width) to suppress physiological noise from cardiac and respiratory fluctuations further improved mean (visual: 196%, motor: 140%) and maximum (visual: 384%, motor: 200%) t-scores and increased extents of activation (visual: 73%, motor: 70%) compared to EPI. Similar sensitivity enhancement, which is attributed to high sampling rate at only moderately reduced temporal signal-to-noise ratio (mean: -52%) and longer sampling of the BOLD effect in the echo-time domain compared to EPI, was measured in auditory cortex. Two-slab EVI further improved temporal resolution for measuring task-related activation and enabled mapping of five major resting state networks (RSNs) in individual subjects in 5 min scans. The bilateral sensorimotor, the default mode and the occipital RSNs were detectable in time frames as short as 75 s. In conclusion, the high sampling rate of real-time multi-slab EVI significantly improves sensitivity for studying the temporal dynamics of hemodynamic responses and for characterizing functional networks at high field strength in short measurement times. (C) 2012 Elsevier Inc. All rights reserved. C1 [Posse, Stefan] Univ New Mexico, Sch Med, 1 Univ New Mexico, Dept Neurol, Albuquerque, NM 87131 USA. [Posse, Stefan] Univ New Mexico, Dept Elect & Comp Engn, Albuquerque, NM 87131 USA. [Posse, Stefan] Univ New Mexico, Dept Phys & Astron, Albuquerque, NM 87131 USA. [Mutihac, Radu] Univ Bucharest, Dept Phys, Bucharest, Romania. [Mutihac, Radu] Walter Reed Army Inst Res, Div Psychiat & Neurosci, Silver Spring, MD USA. [Rick, Jochen; Zaitsev, Maxim] Univ Med Ctr Freiburg, Dept Radiol Med Phys, Freiburg, Germany. [Shane, Matthew] MIND Res Network, Albuquerque, NM USA. [Murray-Krezan, Cristina] Univ New Mexico, Hlth Sci Ctr, Dept Internal Med, Div Epidemiol & Biostat & Prevent Med, Albuquerque, NM 87131 USA. [Speck, Oliver] Univ Magdeburg, Dept Biomed Magnet Resonance, Magdeburg, Germany. RP Posse, S (reprint author), Univ New Mexico, Sch Med, 1 Univ New Mexico, Dept Neurol, MSC 105620, Albuquerque, NM 87131 USA. EM sposse@unm.edu RI Zaitsev, Maxim/F-1173-2010; Speck, Oliver/F-1406-2013 OI Zaitsev, Maxim/0000-0001-7530-1228; Speck, Oliver/0000-0002-6019-5597 FU NIH [1 R01 EB002618-01, 1R41NS062474-01]; DoE/The MIND Research Network [DE-FG02-99ER62764]; NAS/NRC [W81XWH-07-2-0001-0114]; Fulbright ST Grant [495/2010]; University of New Mexico Clinical and Translational Science Center [1UL1RR031977-01] FX We gratefully acknowledge grant support from NIH (1 R01 EB002618-01, 1R41NS062474-01) and DoE/The MIND Research Network (DE-FG02-99ER62764), which supported part of this research. R.M. was supported by NAS/NRC Award #W81XWH-07-2-0001-0114 and Fulbright S&T Grant #495/2010. The statistical analysis was supported by the University of New Mexico Clinical and Translational Science Center, #1UL1RR031977-01. We thank Diana South for providing expert assistance with data collection, Abhishek Reddy Yeruva for assisting with data analysis, and Akio Ernesto Yoshimoto and Kwaku Akrofi for supporting the intial method development. We also thank Larry Wald, Thomas Witzel, Terran Lane, Fa-Hsuan Lin, Vincent Calhoun, Edward Bedrick and David Feinberg for inspiring discussions and critical feedback. NR 48 TC 31 Z9 32 U1 0 U2 14 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 1053-8119 J9 NEUROIMAGE JI Neuroimage PD MAY 15 PY 2012 VL 61 IS 1 BP 115 EP 130 DI 10.1016/j.neuroimage.2012.02.059 PG 16 WC Neurosciences; Neuroimaging; Radiology, Nuclear Medicine & Medical Imaging SC Neurosciences & Neurology; Radiology, Nuclear Medicine & Medical Imaging GA 941HP UT WOS:000303954600013 PM 22398395 ER PT J AU Mittendorf, EA Clifton, GT Holmes, JP Clive, KS Patil, R Benavides, LC Gates, JD Sears, AK Stojadinovic, A Ponniah, S Peoples, GE AF Mittendorf, Elizabeth A. Clifton, Guy T. Holmes, Jarrod P. Clive, Kevin S. Patil, Ritesh Benavides, Linda C. Gates, Jeremy D. Sears, Alan K. Stojadinovic, Alexander Ponniah, Sathibalan Peoples, George E. TI Clinical trial results of the HER-2/neu (E75) vaccine to prevent breast cancer recurrence in high-risk patients From US Military Cancer Institute Clinical Trials Group Study I-01 and I-02 SO CANCER LA English DT Article DE breast cancer; HER2; neu; E75; immunotherapy; cancer vaccines ID HER2/NEU PEPTIDE VACCINE; TRASTUZUMAB; CHEMOTHERAPY; SURVIVAL; THERAPY; CELLS AB BACKGROUND: The authors conducted exploratory phase 1-2 clinical trials vaccinating breast cancer patients with E75, a human leukocyte antigen (HLA) A2/A3restricted HER-2/neu (HER2) peptide, and granulocyte-macrophage colony-stimulating factor. The vaccine is given as adjuvant therapy to prevent disease recurrence. They previously reported that the vaccine is safe and effective in stimulating expansion of E75-specific cytotoxic T cells. Here, they report 24-month landmark analyses of disease-free survival (DFS). METHODS: These dose escalation/schedule optimization trials enrolled lymph node-positive and high-risk lymph node-negative patients with HER2 (immunohistochemistry [IHC] 1-3+) expressing tumors. HLA-A2/A3+ patients were vaccinated; others were followed prospectively as controls for recurrence. DFS was analyzed by Kaplan-Meier curves; groups were compared using log-rank tests. RESULTS: Of 195 enrolled patients, 182 were evaluable: 106 (58.2%) in the vaccinated group and 76 (41.8%) in the control group. The 24-month landmark analysis DFS was 94.3% in the vaccinated group and 86.8% in the control group (P = .08). Importantly, because of trial design, 65% of patients received a lower than optimal vaccine dose. In subset analyses, patients who benefited most from vaccination (vaccinated group vs control group) had lymph node-positive (DFS, 90.2% vs 79.1%; P = .13), HER2 IHC 1+-2+ (DFS, 94.0% vs 79.4%; P = .04), or grade 1 or 2 (DFS, 98.4% vs 86.0%; P = .01) tumors and were optimally dosed (DFS, 97.3% vs 86.8%; P = .08). A booster program has been initiated; no patients receiving booster inoculations have recurred. CONCLUSIONS: The E75 vaccine has clinical efficacy that is more prominent in certain patients. A phase 3 trial enrolling lymph node-positive patients with HER2 low-expressing tumors is warranted. Cancer 2011. (c) 2011 American Cancer Society. C1 [Clifton, Guy T.; Clive, Kevin S.; Benavides, Linda C.; Gates, Jeremy D.; Sears, Alan K.; Peoples, George E.] Brooke Army Med Ctr, Dept Surg, Gen Surg Serv, Ft Sam Houston, TX 78234 USA. [Mittendorf, Elizabeth A.] Univ Texas MD Anderson Canc Ctr, Dept Surg Oncol, Houston, TX 77030 USA. [Holmes, Jarrod P.] USN, San Diego Med Ctr, Dept Hematol & Med Oncol, San Diego, CA 92152 USA. [Patil, Ritesh] Joyce Murtha Breast Canc Ctr, Windber, PA USA. [Patil, Ritesh] Roswell Pk Canc Inst, Dept Med, Buffalo, NY 14263 USA. [Stojadinovic, Alexander] Walter Reed Army Med Ctr, Dept Surg, Washington, DC 20307 USA. [Ponniah, Sathibalan; Peoples, George E.] Uniformed Serv Univ Hlth Sci, Dept Surg, Canc Vaccine Dev Program, United States Mil Canc Inst, Bethesda, MD 20814 USA. RP Peoples, GE (reprint author), Brooke Army Med Ctr, Dept Surg, Gen Surg Serv, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM george.peoples@us.army.mil FU United States Military Cancer Institute, Department of Surgery, Uniformed Services University of the Health Sciences; Clinical Breast Care Project; Department of Clinical Investigation, Walter Reed Army Medical Center; National Cancer Institute [4R00CA133244-03] FX This work was supported by the United States Military Cancer Institute, Department of Surgery, Uniformed Services University of the Health Sciences; Clinical Breast Care Project; and Department of Clinical Investigation, Walter Reed Army Medical Center. Funding sources were not involved with study design; in collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the paper for publication. Additional support was provided by the National Cancer Institute (4R00CA133244-03 to E.A.M.). NR 17 TC 65 Z9 69 U1 1 U2 18 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0008-543X J9 CANCER-AM CANCER SOC JI Cancer PD MAY 15 PY 2012 VL 118 IS 10 BP 2594 EP 2602 DI 10.1002/cncr.26574 PG 9 WC Oncology SC Oncology GA 935DG UT WOS:000303498500005 PM 21989902 ER PT J AU Martin, WA Larson, SL Nestler, CC Fabian, G O'Connor, G Felt, DR AF Martin, W. Andy Larson, S. L. Nestler, C. C. Fabian, G. O'Connor, G. Felt, D. R. TI Hydrated lime for metals immobilization and explosives transformation: Treatability study SO JOURNAL OF HAZARDOUS MATERIALS LA English DT Article DE Hand grenade range; Hydrated lime; Munitions constituents; Range management; Best management practice ID HEAVY-METALS; BIODEGRADATION COLUMN; SEWAGE-SLUDGE; SOIL; HEXAHYDRO-1,3,5-TRINITRO-1,3,5-TRIAZINE; BIOTRANSFORMATION; MINERALIZATION; AMENDMENT; WATER; RDX AB Fragmentation grenades contain Composition B (RDX and TNT) within a steel shell casing. There is the potential for off-site migration of high explosives and metals from hand grenade training ranges by transport in surface water and subsurface transport in leachate. This treatability study used bench-scale columns and mesocosm-scale laboratory lysimeters to investigate the potential of hydrated lime as a soil amendment for in situ remediation of explosives and metals stabilization in hand grenade range soils. Compared to the unamended soil there was a 26-92% reduction of RDX in the leachate and runoff water from the lime treated soils and a 66-83% reduction of zinc in the leachate and runoff water samples; where the hand grenade range metals of concern were zinc, iron, and manganese. The amended soil was maintained at the target pH of greater than 10.5 for optimum explosives decomposition. The treatability study indicated a high potential of success for scale-up to an in situ field study. Published by Elsevier B.V. C1 [Martin, W. Andy; Larson, S. L.; Felt, D. R.] USA, Corps Engineers, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. [Nestler, C. C.] Appl Res Associates Inc, Vicksburg, MS 39180 USA. [Fabian, G.] USA, Aberdeen Test Ctr, Aberdeen Proving Ground, MD 21005 USA. [O'Connor, G.] USA, RDECOM ARDEC, Picatinny Arsenal, NJ 07806 USA. RP Martin, WA (reprint author), USA, Corps Engineers, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. EM Andy.Martin@usace.army.mil; Deborah.Felt@usace.army.mil FU Environmental Security Technology Certification Program (ESTCP) [ER-0216] FX This work was funded by the Environmental Security Technology Certification Program (ESTCP) as field demonstration project ER-0216. This project was awarded the ESTCP Project of the Year (2007). The authors wish to thank Ms. Beth-Anee Johnson, Integrated Training Area Management Office (ITAM). The gracious participation of the range control personnel for the assistance with obtaining range samples in support of this project is also acknowledged. Technical assistance was provided by Mr. Milton Beverly (Environmental Research and Development, Inc. - ERAD), Mr. Chris Griggs (ERDC-EL), Ms. Michelle Thompson (Applied Research Associates, Inc., currently with ERDC-EL), Ms. LeeAnn Riggs and Ms. Deborah Regan (SpecPro), Mr. Casey Trest (Mississippi State University), and Ms. Tarmiko Graham (Alcorn State University). NR 40 TC 2 Z9 2 U1 1 U2 11 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0304-3894 J9 J HAZARD MATER JI J. Hazard. Mater. PD MAY 15 PY 2012 VL 215 BP 280 EP 286 DI 10.1016/j.jhazmat.2012.02.066 PG 7 WC Engineering, Environmental; Engineering, Civil; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA 932QU UT WOS:000303306400035 PM 22445717 ER PT J AU Allen, JL Wolfenstine, J Rangasamy, E Sakamoto, J AF Allen, J. L. Wolfenstine, J. Rangasamy, E. Sakamoto, J. TI Effect of substitution (Ta, Al, Ga) on the conductivity of Li7La3Zr2O12 SO JOURNAL OF POWER SOURCES LA English DT Article DE Garnet; Li; Ta; Cubic; Ionic conductivity; Hot-pressing ID LITHIUM ION CONDUCTION; SOLID-ELECTROLYTE; GARNETS; TRANSPORT; CHEMISTRY AB Cubic garnets of composition Li6.75La3Zr1.75Ta0.25O12. Li6.15La3Zr1.75Ta0.25Al0.2O12, and Li6.15La3Zr1.75Ta0.25Ga0.2O12 were prepared from a co-precipitated precursor and consolidated by hot-pressing to a relative density of similar to 96-98%. The total Li-ion conductivities at 298 K and activation energies (in parentheses) of Li6.75La3Zr1.75Ta0.25O12. Li6.15La3Zr1.75Ta0.25Al0.2O12 and Li6.15La3Zr1.75Ta0.25Ga0.2O12 were 0.87 mS cm(-1) (0.22 eV), 0.37 mS cm(-1) (0.30 eV) and 0.41 mS cm(-1) (0.27 eV), respectively. The above results suggest that cubic stabilizing substitutions outside of the Li-ion sub-lattice are preferable to obtain faster Li-ion conductivity. Published by Elsevier B.V. C1 [Allen, J. L.; Wolfenstine, J.] USA, Res Lab, RDRL SED C, Adelphi, MD 20783 USA. [Rangasamy, E.; Sakamoto, J.] Michigan State Univ, Dept Chem Engn & Mat Sci, E Lansing, MI 48824 USA. RP Allen, JL (reprint author), USA, Res Lab, RDRL SED C, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM jan.l.allen8.civ@mail.mil RI Rangasamy, Ezhiylmurugan/K-8340-2013 FU US Army Research Laboratory (ARL); US Army Research Office (ARO) FX J.L.A. and J.W. would like to acknowledge support of the US Army Research Laboratory (ARL). E.R. and J.S. authors would like to acknowledge the support of the US Army Research Office (ARO). NR 25 TC 93 Z9 95 U1 26 U2 193 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0378-7753 J9 J POWER SOURCES JI J. Power Sources PD MAY 15 PY 2012 VL 206 BP 315 EP 319 DI 10.1016/j.jpowsour.2012.01.131 PG 5 WC Chemistry, Physical; Electrochemistry; Energy & Fuels; Materials Science, Multidisciplinary SC Chemistry; Electrochemistry; Energy & Fuels; Materials Science GA 925IR UT WOS:000302755400043 ER PT J AU Singh, J Mukherjee, A Sengupta, SK Im, J Peterson, GW Whitten, JE AF Singh, Jagdeep Mukherjee, Anupama Sengupta, Sandip K. Im, Jisun Peterson, Gregory W. Whitten, James E. TI Sulfur dioxide and nitrogen dioxide adsorption on zinc oxide and zirconium hydroxide nanoparticles and the effect on photoluminescence SO APPLIED SURFACE SCIENCE LA English DT Article DE Metal oxide; Photoelectron spectroscopy; Photoluminescence; Sensor ID SURFACE-CHEMISTRY; ZNO; PHOTOEMISSION; REACTIVITY; REMOVAL; SO2; NO2; CO AB Nanoparticulate zinc oxide and micron-size zirconium hydroxide powders have been exposed to sulfur dioxide and nitrogen dioxide by flowing the gases, diluted with nitrogen, over powder samples. X-ray photoelectron spectroscopy (XPS), Raman spectroscopy, and thermogravimetric analysis (TGA) indicate strongly bound, chemisorbed SO3 and NO3 surface species. Two pre-treatments of the nanoparticulate ZnO samples prior to gas exposure have been investigated: (1) drying overnight in a vacuum oven and (2) hydrating the samples by placing them overnight in water-saturated air. A dramatic difference in reactivity of ZnO is observed, with approximately two-fold and ten-fold greater uptake of NO2 and SO2, respectively, measured by XPS for the hydrated samples relative to the dried ones. Transmission electron microscopy (TEM) demonstrates that the greater uptake arises from a morphology change in the case of the hydrated samples. For zirconium hydroxide, no morphology change is observed for hydrated samples, and SO4 (ads), in addition to SO3 (ads), is indicated by XPS. ZnO and Zr(OH)(4) both exhibit photoluminescence (PL) spectra, with peak intensities that change dramatically due to hydration and subsequent exposure to SO2 and NO2 gases. Dosing of the powders with these gases effectively reverts the PL spectra to those corresponding to less hydration. (C) 2012 Elsevier B.V. All rights reserved. C1 [Singh, Jagdeep; Mukherjee, Anupama; Sengupta, Sandip K.; Im, Jisun; Whitten, James E.] Univ Massachusetts Lowell, Dept Chem, Lowell, MA 01854 USA. [Peterson, Gregory W.] USA, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. RP Whitten, JE (reprint author), Univ Massachusetts Lowell, Dept Chem, Lowell, MA 01854 USA. EM James_Whitten@uml.edu FU Army Research Office [BA07PR0105] FX The authors acknowledge support of the Army Research Office. This work was conducted under Defense Threat Reduction Agency, Project no.BA07PR0105. NR 20 TC 12 Z9 12 U1 7 U2 54 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0169-4332 J9 APPL SURF SCI JI Appl. Surf. Sci. PD MAY 15 PY 2012 VL 258 IS 15 BP 5778 EP 5785 DI 10.1016/j.apsusc.2012.02.093 PG 8 WC Chemistry, Physical; Materials Science, Coatings & Films; Physics, Applied; Physics, Condensed Matter SC Chemistry; Materials Science; Physics GA 916XE UT WOS:000302135700042 ER PT J AU Kumar, A Li, L Chaturvedi, A Brzostowski, J Chittigori, J Pierce, S Samuelson, LA Sandman, D Kumar, J AF Kumar, Abhishek Li, Lian Chaturvedi, Akanksha Brzostowski, Joseph Chittigori, Joshna Pierce, Susan Samuelson, Lynne A. Sandman, Daniel Kumar, Jayant TI Two-photon fluorescence properties of curcumin as a biocompatible marker for confocal imaging SO APPLIED PHYSICS LETTERS LA English DT Article ID CROSS-SECTIONS; MICROSCOPY; CELLS; DOTS AB Two-photon (TP) fluorescence properties of an antioxidant and anti-tumor molecule, curcumin, were investigated. The two-photon absorption (TPA) action cross-section was measured in organic solvents and found to be 6 GM in tetrahydrofuran and 2 GM in dimethyl sulfoxide. The measured TPA cross-section is comparable to that of rhodamine 6G. One-photon and TP confocal microscopy has demonstrated that curcumin is internalized in cells and can be used for imaging applications. Our investigation indicates that curcumin is a viable biocompatible TP fluorescent marker. (C) 2012 American Institute of Physics. [http://dx.doi.org/10.1063/1.4717753] C1 [Kumar, Abhishek; Chittigori, Joshna; Sandman, Daniel; Kumar, Jayant] Univ Massachusetts Lowell, Ctr Adv Mat, Lowell, MA 01854 USA. [Kumar, Abhishek; Kumar, Jayant] Univ Massachusetts Lowell, Dept Phys, Lowell, MA 01854 USA. [Li, Lian; Samuelson, Lynne A.] USA, Natick Soldier Res Dev & Engn Ctr, Natick, MA 01760 USA. [Chaturvedi, Akanksha; Brzostowski, Joseph; Pierce, Susan] NIAID, LIG, NIH, Rockville, MD 20852 USA. [Chittigori, Joshna; Sandman, Daniel] Univ Massachusetts Lowell, Dept Chem, Lowell, MA 01854 USA. RP Kumar, A (reprint author), Univ Massachusetts Lowell, Ctr Adv Mat, Lowell, MA 01854 USA. EM Jayant_Kumar@uml.edu NR 14 TC 13 Z9 13 U1 2 U2 16 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD MAY 14 PY 2012 VL 100 IS 20 AR 203701 DI 10.1063/1.4717753 PG 4 WC Physics, Applied SC Physics GA 945HZ UT WOS:000304265000097 ER PT J AU Koku, H Maier, RS Schure, MR Lenhoff, AM AF Koku, Harun Maier, Robert S. Schure, Mark R. Lenhoff, Abraham M. TI Modeling of dispersion in a polymeric chromatographic monolith SO JOURNAL OF CHROMATOGRAPHY A LA English DT Article DE Monolith; CIM disk; Dispersion; Random walk; Image-based simulation; Entrapment ID PERFORMANCE LIQUID-CHROMATOGRAPHY; RANDOM SPHERE PACKINGS; POROUS SILICA COLUMNS; STATIONARY PHASES; PORE STRUCTURE; MASS-TRANSFER; PACKED-BEDS; POLYMETHACRYLATE MONOLITHS; HYDRODYNAMIC DISPERSION; DIFFUSION-COEFFICIENT AB Dispersion in a commercial polymeric monolith was simulated on a sample geometry obtained by direct imaging using high-resolution electron microscopy. A parallelized random walk algorithm, implemented using a velocity field obtained previously by the lattice-Boltzmann method, was used to model mass transfer. Both point particles and probes of finite size were studied. Dispersion simulations with point particles using periodic boundaries resulted in plate heights that varied almost linearly with flow rate, at odds with the weaker dependence suggested by experimental observations and predicted by theory. This discrepancy resulted from the combined effect of the artificial symmetry in the velocity field and the periodic boundaries implemented to emulate macroscopic column lengths. Eliminating periodicity and simulating a single block length instead resulted in a functional dependence of plate heights on flow rate more in accord with experimental trends and theoretical predictions for random media. The lower values of the simulated plate heights than experimental ones are attributed in part to the presence of walls in real systems, an effect not modeled by the algorithm. On the other hand, analysis of transient dispersion coefficients and comparison of lateral particle positions at the entry and exit hinted at non-asymptotic behavior and a strong degree of correlation that was presumably a consequence of preferential high-velocity pathways in the raw sample block. Simulations with finite-sized probes resulted in particle trajectories that frequently terminated at narrow constrictions of the geometry. The amount of entrapment was predicted to increase monotonically with flow rate, evidently due to the relative contributions to transport by convection that carries particles to choke-points and diffusion that dislodges these entrapped particles. The overall effect is very similar to a flow-dependent entrapment phenomenon previously observed experimentally for adenovirus. (c) 2012 Elsevier B.V. All rights reserved. C1 [Koku, Harun; Lenhoff, Abraham M.] Univ Delaware, Dept Chem & Biomol Engn, Newark, DE 19716 USA. [Maier, Robert S.] USA, Informat Technol Lab, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. [Schure, Mark R.] Dow Chem Co USA, Theoret Separat Sci Lab, Spring House, PA 19477 USA. RP Lenhoff, AM (reprint author), Univ Delaware, Dept Chem & Biomol Engn, Newark, DE 19716 USA. EM lenhoff@udel.edu OI Lenhoff, Abraham/0000-0002-7831-219X FU National Institutes of Health (NIH) [R01 GM75047] FX Financial support for this work was provided by the National Institutes of Health (NIH) under grant R01 GM75047. NR 77 TC 27 Z9 27 U1 3 U2 49 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0021-9673 J9 J CHROMATOGR A JI J. Chromatogr. A PD MAY 11 PY 2012 VL 1237 BP 55 EP 63 DI 10.1016/j.chroma.2012.03.005 PG 9 WC Biochemical Research Methods; Chemistry, Analytical SC Biochemistry & Molecular Biology; Chemistry GA 932CW UT WOS:000303269000006 PM 22465685 ER PT J AU Lumsden, JM Nurmukhambetova, S Klein, JH Sattabongkot, J Bennett, JW Bertholet, S Fox, CB Reed, SG Ockenhouse, CF Howard, RF Polhemus, ME Yadava, A AF Lumsden, Joanne M. Nurmukhambetova, Saule Klein, Jennifer H. Sattabongkot, Jetsumon Bennett, Jason W. Bertholet, Sylvie Fox, Christopher B. Reed, Steven G. Ockenhouse, Christian F. Howard, Randall F. Polhemus, Mark E. Yadava, Anjali TI Evaluation of immune responses to a Plasmodium vivax CSP-based recombinant protein vaccine candidate in combination with second-generation adjuvants in mice SO VACCINE LA English DT Article DE Malaria; Plasmodium vivax; Circumsporozoite protein; Vaccine; TLR agonists; Immunogenicity ID T-CELL RESPONSES; PROTECTIVE IMMUNITY; GLYCOPROTEIN VACCINE; FALCIPARUM-MALARIA; NONHUMAN-PRIMATES; GAMMA-INTERFERON; RESIQUIMOD R-848; DNA VACCINATION; DENDRITIC CELLS; MODIFIER R-848 AB Plasmodium vivax is the major cause of malaria outside of sub-Saharan Africa and causes morbidity and results in significant economic impact in developing countries. In order to produce a P. vivax vaccine for global use, we have previously reported the development of VMP001, based on the circumsporozoite protein (CSP) of P. vivax. Our interest is to evaluate second-generation vaccine formulations to identify novel combinations of adjuvants capable of inducing strong, long-lasting immune responses. In this study, groups of C57BL/6J mice were immunized subcutaneously three times with VMP001 emulsified with synthetic TLR4 (GLA) or TLR7/8 (R848) agonist in stable emulsion (SE), a combination of the TLR4 and TLR7/8 agonists, or SE alone. Sera and splenocytes were tested for the presence of antigen-specific humoral and cellular responses, respectively. All groups of mice generated high titers of anti-P. vivax IgG antibodies as detected by ELISA and immunofluorescence assay. GLA-SE promoted a shift in the antibody response to a Th1 profile, as demonstrated by the change in IgG2c/IgG1 ratio. In addition, GLA-SE induced a strong cellular immune response characterized by multi-functional, antigen-specific CD4(+) T cells secreting IL-2, TNF and IFN-gamma. In contrast, mice immunized with SE or R848-SE produced low numbers of antigen-specific CD4(+) T cells, and these T cells secreted IL-2 and TNF, but not IFN-gamma. Finally, R848-SE did not enhance the immune response compared to GLA-SE alone. Based on these results, we conclude that the combination of VMP001 and CIA-SE is highly immunogenic in mice and may serve as a potential second-generation vaccine candidate against vivax malaria. Published by Elsevier Ltd. C1 [Lumsden, Joanne M.; Nurmukhambetova, Saule; Klein, Jennifer H.; Bennett, Jason W.; Ockenhouse, Christian F.; Polhemus, Mark E.; Yadava, Anjali] Walter Reed Army Inst Res, Malaria Vaccine Branch, Mil Malaria Res Program, Silver Spring, MD 20910 USA. [Sattabongkot, Jetsumon] Armed Forces Inst Res, Div Entomol, Bangkok, Thailand. [Bertholet, Sylvie; Fox, Christopher B.; Reed, Steven G.; Howard, Randall F.] Infect Dis Res Inst, Seattle, WA 98104 USA. RP Yadava, A (reprint author), Walter Reed Army Inst Res, Malaria Vaccine Branch, Mil Malaria Res Program, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM anjali.yadava@us.army.mil RI Bennett, Jason/B-3547-2011; OI Fox, Christopher/0000-0002-4644-2619 FU United States Army Medical Materiel Development Activity; Military Infectious Diseases Research Program (Fort Detrick, Maryland); Bill and Melinda Gates Foundation [42387] FX This work was supported by the United States Army Medical Materiel Development Activity and the Military Infectious Diseases Research Program (Fort Detrick, Maryland); and in part by grant #42387 to SGR from the Bill and Melinda Gates Foundation. The Funders had no role in the design and/or execution of this study. The opinions or assertions contained herein are the private views of the authors, and are not to be construed as official or as reflecting the views of the Department of the Army or the Department of Defense. NR 58 TC 18 Z9 18 U1 1 U2 7 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X J9 VACCINE JI Vaccine PD MAY 9 PY 2012 VL 30 IS 22 BP 3311 EP 3319 DI 10.1016/j.vaccine.2012.03.004 PG 9 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 940PH UT WOS:000303905000009 PM 22425788 ER PT J AU Goldstein, JH Caldarone, G Duarte, TK Ennaanay, D Hannahs, N Mendoza, G Polasky, S Wolny, S Daily, GC AF Goldstein, Joshua H. Caldarone, Giorgio Duarte, Thomas Kaeo Ennaanay, Driss Hannahs, Neil Mendoza, Guillermo Polasky, Stephen Wolny, Stacie Daily, Gretchen C. TI Integrating ecosystem-service tradeoffs into land-use decisions SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA LA English DT Article DE conservation; mapping; private lands ID CONSERVATION; ENVIRONMENT; SCIENCE; FORESTS; POLICY AB Recent high-profile efforts have called for integrating ecosystem-service values into important societal decisions, but there are few demonstrations of this approach in practice. We quantified ecosystem-service values to help the largest private landowner in Hawaii, Kamehameha Schools, design a land-use development plan that balances multiple private and public values on its North Shore land holdings (Island of O'ahu) of similar to 10,600 ha. We used the InVEST software tool to evaluate the environmental and financial implications of seven planning scenarios encompassing contrasting land-use combinations including biofuel feedstocks, food crops, forestry, livestock, and residential development. All scenarios had positive financial return relative to the status quo of negative return. However, tradeoffs existed between carbon storage and water quality as well as between environmental improvement and financial return. Based on this analysis and community input, Kamehameha Schools is implementing a plan to support diversified agriculture and forestry. This plan generates a positive financial return ($10.9 million) and improved carbon storage (0.5% increase relative to status quo) with negative relative effects on water quality (15.4% increase in potential nitrogen export relative to status quo). The effects on water quality could be mitigated partially (reduced to a 4.9% increase in potential nitrogen export) by establishing vegetation buffers on agricultural fields. This plan contributes to policy goals for climate change mitigation, food security, and diversifying rural economic opportunities. More broadly, our approach illustrates how information can help guide local land-use decisions that involve tradeoffs between private and public interests. C1 [Goldstein, Joshua H.] Colorado State Univ, Dept Human Dimens Nat Resources, Ft Collins, CO 80523 USA. [Caldarone, Giorgio; Duarte, Thomas Kaeo; Hannahs, Neil] Kamehameha Sch, Land Assets Div, Honolulu, HI 96813 USA. [Ennaanay, Driss; Wolny, Stacie; Daily, Gretchen C.] Stanford Univ, Dept Biol, Stanford, CA 94305 USA. [Ennaanay, Driss; Wolny, Stacie; Daily, Gretchen C.] Stanford Univ, Woods Inst Environm, Stanford, CA 94305 USA. [Mendoza, Guillermo] USA, Corps Engineers, Inst Water Resources, Alexandria, VA 22315 USA. [Polasky, Stephen] Univ Minnesota, Dept Appl Econ, St Paul, MN 55108 USA. [Polasky, Stephen] Univ Minnesota, Dept Ecol Evolut & Behav, St Paul, MN 55108 USA. RP Goldstein, JH (reprint author), Colorado State Univ, Dept Human Dimens Nat Resources, Ft Collins, CO 80523 USA. EM joshua.goldstein@colostate.edu; gdaily@stanford.edu FU Winslow Foundation FX We thank the Land Assets Division at Kamehameha Schools for supporting this project and providing input into research design and analysis, for facilitating site visits, and for access to spatial data layers. We also thank the Winslow Foundation, P. and H. Bing, and V. and R. Sant for support. NR 38 TC 122 Z9 147 U1 34 U2 294 PU NATL ACAD SCIENCES PI WASHINGTON PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA SN 0027-8424 J9 P NATL ACAD SCI USA JI Proc. Natl. Acad. Sci. U. S. A. PD MAY 8 PY 2012 VL 109 IS 19 BP 7565 EP 7570 DI 10.1073/pnas.1201040109 PG 6 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 942ZQ UT WOS:000304090600086 PM 22529388 ER PT J AU Woodward, N Gallinat, C Rodak, LE Metcalfe, GD Shen, H Wraback, M AF Woodward, Nathaniel Gallinat, C. Rodak, L. E. Metcalfe, G. D. Shen, H. Wraback, M. TI Enhanced THz emission from c-plane InxGa1-xN due to piezoelectric field-induced electron transport SO APPLIED PHYSICS LETTERS LA English DT Article ID NITRIDE SEMICONDUCTORS; TERAHERTZ EMISSION; POLARIZATION; RADIATION; SURFACES AB Enhanced terahertz emission from coherently strained InxGa1-xN epilayers on GaN is observed, which exceeds or is comparable to bulk InAs emission at pump wavelengths of 400 nm or 800 nm, respectively. The inverted terahertz waveform from the InxGa1-xN/GaN heterostructure indicates that the dominant terahertz generation mechanism is electron acceleration toward the InxGa1-xN surface in an internal electric field primarily associated with piezoelectric polarization charge at the heterointerface, rather than diffusive transport away from the surface typically observed in bulk semiconductors. The persistence of the inverted waveform for 266 nm excitation provides evidence of ultrafast electron relaxation via LO phonon emission. (C) 2012 American Institute of Physics. [http://dx.doi.org/10.1063/1.4707387] C1 [Woodward, Nathaniel; Gallinat, C.; Rodak, L. E.; Metcalfe, G. D.; Shen, H.; Wraback, M.] USA, Res Lab, Sensors & Electron Devices Directorate, RDRL SEE M, Adelphi, MD 20783 USA. RP Woodward, N (reprint author), USA, Res Lab, Sensors & Electron Devices Directorate, RDRL SEE M, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. FU U.S. Army Research Laboratory FX N. Woodward, L. E. Rodak, and C. Gallinat gratefully acknowledge the support by the U.S. Army Research Laboratory Postdoctoral Fellowship Program administered by the Oak Ridge Associated Universities through a contract with the U.S. Army Research Laboratory. NR 15 TC 3 Z9 3 U1 0 U2 9 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD MAY 7 PY 2012 VL 100 IS 19 AR 191110 DI 10.1063/1.4707387 PG 4 WC Physics, Applied SC Physics GA 943GG UT WOS:000304108000010 ER PT J AU Yu, XP Wallqvist, A Reifman, J AF Yu, Xueping Wallqvist, Anders Reifman, Jaques TI Inferring high-confidence human protein-protein interactions SO BMC BIOINFORMATICS LA English DT Article DE High confidence; Human protein interaction network; Protein-protein interactions ID MOLECULAR INTERACTION DATABASE; INTERACTION NETWORK; CYTOPLASMIC DYNEIN-2; EXPRESSION; GIP; MAP; DEHYDROGENASE; MECHANISM; REVEALS; BIOLOGY AB Background: As numerous experimental factors drive the acquisition, identification, and interpretation of protein-protein interactions (PPIs), aggregated assemblies of human PPI data invariably contain experiment-dependent noise. Ascertaining the reliability of PPIs collected from these diverse studies and scoring them to infer high-confidence networks is a non-trivial task. Moreover, a large number of PPIs share the same number of reported occurrences, making it impossible to distinguish the reliability of these PPIs and rank-order them. For example, for the data analyzed here, we found that the majority (>83%) of currently available human PPIs have been reported only once. Results: In this work, we proposed an unsupervised statistical approach to score a set of diverse, experimentally identified PPIs from nine primary databases to create subsets of high-confidence human PPI networks. We evaluated this ranking method by comparing it with other methods and assessing their ability to retrieve protein associations from a number of diverse and independent reference sets. These reference sets contain known biological data that are either directly or indirectly linked to interactions between proteins. We quantified the average effect of using ranked protein interaction data to retrieve this information and showed that, when compared to randomly ranked interaction data sets, the proposed method created a larger enrichment (similar to 134%) than either ranking based on the hypergeometric test (similar to 109%) or occurrence ranking (similar to 46%). Conclusions: From our evaluations, it was clear that ranked interactions were always of value because higher-ranked PPIs had a higher likelihood of retrieving high-confidence experimental data. Reducing the noise inherent in aggregated experimental PPIs via our ranking scheme further increased the accuracy and enrichment of PPIs derived from a number of biologically relevant data sets. These results suggest that using our high-confidence protein interactions at different levels of confidence will help clarify the topological and biological properties associated with human protein networks. C1 [Yu, Xueping; Wallqvist, Anders; Reifman, Jaques] USA, Biotechnol High Performance Comp Software Applica, Telemed & Adv Technol Res Ctr, Med Res & Mat Command, Ft Detrick, MD 21702 USA. RP Reifman, J (reprint author), USA, Biotechnol High Performance Comp Software Applica, Telemed & Adv Technol Res Ctr, Med Res & Mat Command, Ft Detrick, MD 21702 USA. EM jaques.reifman@us.army.mil OI wallqvist, anders/0000-0002-9775-7469 FU Military Operational Medicine Research Program of the U.S. Army Medical Research and Materiel Command, Ft. Detrick, Maryland, as part of the U.S. Army's Network Science Initiative FX We thank Drs. Jacob Feala, Vesna Memisevic, and Xin Hu for helpful discussions. The authors were supported by the Military Operational Medicine Research Program of the U.S. Army Medical Research and Materiel Command, Ft. Detrick, Maryland, as part of the U.S. Army's Network Science Initiative. The opinions and assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the U.S. Army or the U.S. Department of Defense. This paper has been approved for public release with unlimited distribution. NR 52 TC 20 Z9 20 U1 1 U2 3 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1471-2105 J9 BMC BIOINFORMATICS JI BMC Bioinformatics PD MAY 4 PY 2012 VL 13 AR 79 DI 10.1186/1471-2105-13-79 PG 16 WC Biochemical Research Methods; Biotechnology & Applied Microbiology; Mathematical & Computational Biology SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology; Mathematical & Computational Biology GA 986NP UT WOS:000307348800001 PM 22558947 ER PT J AU Foley, DH Harrison, G Murphy, JR Dowler, M Rueda, LM Wilkerson, RC AF Foley, Desmond H. Harrison, Genelle Murphy, Jittawadee R. Dowler, Megan Rueda, Leopoldo M. Wilkerson, Richard C. TI Mosquito bisection as a variable in estimates of PCR-derived malaria sporozoite rates SO MALARIA JOURNAL LA English DT Article DE Plasmodium; Malaria; Sporozoite rate; Oocyst; PCR; Dissection; Anopheles ID POLYMERASE-CHAIN-REACTION; LINKED-IMMUNOSORBENT-ASSAY; PLASMODIUM-VIVAX SPOROZOITES; 18S RIBOSOMAL-RNA; ANOPHELES MOSQUITOS; SALIVARY-GLANDS; MULTIPLEX PCR; FALCIPARUM; PARASITE; IDENTIFICATION AB Background: Highly sensitive polymerase chain reaction (PCR) methods offer an alternative to the light microscopy examination of mosquito salivary glands for the determination of malaria sporozoite rates in wild caught female Anopheles. Removal of mosquito abdomens is assumed to eliminate false positives caused by malaria oocyst DNA in the midgut. This assumption has not been tested with current gold standard PCR assays, and for the variety of conditions that specimens could encounter in the laboratory and field. Methods: Laboratory Anopheles stephensi were used that had been infected with Plasmodium falciparum 6-7 days and 14 days post infection (p.i.), when oocysts only and oocysts + sporozoites, respectively, are developed. Mosquitoes were killed and immediately frozen, air dried before being frozen, or stored under humid conditions overnight before being frozen, to simulate a range of conditions in the field. Additionally, abdomens were removed anterior to, at, or posterior to the junction of the abdomen and thorax, and both portions were processed using a standard nested PCR of the small sub-unit nuclear ribosomal genes (ssrDNA) with products visualized on agarose gels. Results: Overall, 4.1 % (4/97) of head + thorax samples that were 6-7 days p.i. gave apparent false positives for sporozoites, compared to 9.3 % (9/97) that were positive for abdomens. No positives (0/52) were obtained when similar specimens were bisected anterior to the junction of the thorax and abdomen, compared to 21.2 % (11/52) that were positive for posterior portions. Multiple bands were noted for positives from the 'Frozen' treatment and the rate of false negatives due to DNA degradation appears higher under the 'Humid' treatment. Reproducibility of results for the 'Frozen' treatment was 90 %. Conclusions: Despite the importance of specimen condition and the bisection step in determining sporozoite rates, little attention has been paid to them in the literature. Recommendations from this study are that: 1) care needs to be taken to reduce DNA degradation in the field; 2) mosquito abdomens be separated anterior to the junction of the thorax and abdomen; and 3) DNA sequencing of a subsample of positive results should be undertaken if possible. C1 [Foley, Desmond H.; Harrison, Genelle; Murphy, Jittawadee R.; Dowler, Megan; Rueda, Leopoldo M.; Wilkerson, Richard C.] Walter Reed Army Inst Res, Entomol Branch, Silver Spring, MD 20910 USA. RP Foley, DH (reprint author), Walter Reed Army Inst Res, Entomol Branch, Silver Spring, MD 20910 USA. EM foleydes@si.edu RI Valle, Ruben/A-7512-2013; OI Foley, Desmond/0000-0001-7525-4601 NR 34 TC 5 Z9 5 U1 0 U2 4 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1475-2875 J9 MALARIA J JI Malar. J. PD MAY 2 PY 2012 VL 11 AR 145 DI 10.1186/1475-2875-11-145 PG 7 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA 985GY UT WOS:000307252600001 PM 22551078 ER PT J AU Henning, PC Nindl, BC Rarick, KR Scofield, DS Pierce, JR Stanger, MJ Lieberman, HR AF Henning, Paul C. Nindl, Bradley C. Rarick, Kevin R. Scofield, Dennis S. Pierce, Joseph R. Stanger, Michael J. Lieberman, Harris R. TI Effects Of Caloric Restriction Compared To Caloric Balance On The Response Of The IGF-I System SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract C1 [Henning, Paul C.; Nindl, Bradley C.; Rarick, Kevin R.; Scofield, Dennis S.; Pierce, Joseph R.; Stanger, Michael J.; Lieberman, Harris R.] USA, Environm Med Res Inst, Natick, MA 01760 USA. RI SCOFIELD, DENNIS/F-3636-2015 NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2012 VL 44 SU 2 BP 97 EP 97 PG 1 WC Sport Sciences SC Sport Sciences GA 027OT UT WOS:000310363300044 ER PT J AU Hoffman, EP Devaney, J Thompson, P Zambraski, E Visich, P Gordon, P Gordish-Dressman, H Pescatello, L Zoeller, R Moyna, N Angelopoulos, T Clarkson, P AF Hoffman, Eric P. Devaney, Joseph Thompson, Paul Zambraski, Edward Visich, Paul Gordon, Paul Gordish-Dressman, Heather Pescatello, Linda Zoeller, Richard Moyna, Niall Angelopoulos, Theodore Clarkson, Priscilla TI Osteopontin: A Complex Genetic Modifier Of Muscle Size And Muscle Damage. SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract C1 [Hoffman, Eric P.; Devaney, Joseph; Gordish-Dressman, Heather] Childrens Natl Med Ctr, Washington, DC 20010 USA. [Thompson, Paul] Hartford Hosp, Hartford, CT 06115 USA. [Zambraski, Edward] USA, Environm Med Res Inst, Natick, MA 01760 USA. [Visich, Paul] Univ New England, Biddiford, ME USA. [Gordon, Paul] Univ Michigan, Ann Arbor, MI 48109 USA. [Pescatello, Linda] Univ Connecticut, Storrs, CT USA. [Zoeller, Richard] Florida Atlantic Univ, Davie, FL USA. [Moyna, Niall] Dublin City Univ, Dublin 9, Ireland. [Angelopoulos, Theodore] Univ Cent Florida, Orlando, FL 32816 USA. [Clarkson, Priscilla] Univ Massachusetts, Amherst, MA 01003 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2012 VL 44 SU 2 BP 98 EP 98 PG 1 WC Sport Sciences SC Sport Sciences GA 027OT UT WOS:000310363300049 ER PT J AU Lynch, JH Kane, SF AF Lynch, James H. Kane, Shawn F. TI Chest Pain In A 33-year-old Elite Soldier-Athlete - Combat SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract C1 [Lynch, James H.; Kane, Shawn F.] Womack Army Med Ctr, Ft Bragg, NC USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2012 VL 44 SU 2 BP 132 EP 133 PG 2 WC Sport Sciences SC Sport Sciences GA 027OT UT WOS:000310363301030 ER PT J AU Spiering, BA Walker, LA Simpson, K Frykman, PN Ward, RC Sharp, MA AF Spiering, Barry A. Walker, Leila A. Simpson, Kathleen Frykman, Peter N. Ward, Reeshemah C. Sharp, Marilyn A. TI Reliability of a Test Battery Designed to Assess Soldier Occupational Task Performance SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract C1 [Spiering, Barry A.; Walker, Leila A.; Simpson, Kathleen; Frykman, Peter N.; Ward, Reeshemah C.; Sharp, Marilyn A.] USA, Environm Med Res Inst, Natick, MA 01760 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2012 VL 44 SU 2 BP 204 EP 204 PG 1 WC Sport Sciences SC Sport Sciences GA 027OT UT WOS:000310363301198 ER PT J AU Leahy, GD Crowder, TA Mayhew, JL AF Leahy, Guy D. Crowder, Todd A. Mayhew, Jerry L. TI Allometric Scaling Of Air Force Fitness Test Performances In Men SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract C1 [Leahy, Guy D.] Davis Monthan AFB, Tucson, AZ USA. [Crowder, Todd A.] US Mil Acad, West Point, NY 10996 USA. [Mayhew, Jerry L.] Truman State Univ, Kirksville, MO USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2012 VL 44 SU 2 BP 205 EP 205 PG 1 WC Sport Sciences SC Sport Sciences GA 027OT UT WOS:000310363301202 ER PT J AU Crowder, TA AF Crowder, Todd A. TI "Pre-Fatigue" Simulated Casualty Evacuation Task: The Role of Body Composition, Fitness and Physical Performance Grades SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract C1 [Crowder, Todd A.] US Mil Acad, West Point, NY 10996 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2012 VL 44 SU 2 BP 206 EP 206 PG 1 WC Sport Sciences SC Sport Sciences GA 027OT UT WOS:000310363301203 ER PT J AU Clearfield, E Hauret, KG Garrett, P Westrick, A Knapik, JJ AF Clearfield, Elizabeth Hauret, Keith G. Garrett, Phillip Westrick, Ashly Knapik, Joseph J. TI Injuries among Army Recruits during Occupational Training for Military Police and Combat Engineers SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract C1 [Clearfield, Elizabeth; Hauret, Keith G.; Garrett, Phillip; Westrick, Ashly; Knapik, Joseph J.] USA, Inst Publ Hlth, Edgewood, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2012 VL 44 SU 2 BP 304 EP 304 PG 1 WC Sport Sciences SC Sport Sciences GA 027OT UT WOS:000310363302131 ER PT J AU Dufek, JS Aldridge, JM Mercer, JA Gouws, PL AF Dufek, Janet S. Aldridge, Jennifer M. Mercer, John A. Gouws, Philana-Lee TI Does Backward Walking Enhance Gait or Balance Performance in Older Adults? SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract C1 [Dufek, Janet S.; Mercer, John A.; Gouws, Philana-Lee] Univ Nevada, Las Vegas, NV 89154 USA. [Aldridge, Jennifer M.] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. NR 0 TC 0 Z9 0 U1 1 U2 7 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2012 VL 44 SU 2 BP 432 EP 432 PG 1 WC Sport Sciences SC Sport Sciences GA 027OT UT WOS:000310363302568 ER PT J AU Sauer, SG Seay, JF Frykman, PN AF Sauer, Shane G. Seay, Joseph F. Frykman, Peter N. TI Women's Leg Stiffness Increases More than Men's During Fast Forced Cadence Load Carriag SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract C1 [Sauer, Shane G.; Seay, Joseph F.; Frykman, Peter N.] USA, Environm Med Res Inst, Natick, MA 01760 USA. NR 0 TC 0 Z9 0 U1 2 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2012 VL 44 SU 2 BP 432 EP 433 PG 2 WC Sport Sciences SC Sport Sciences GA 027OT UT WOS:000310363302570 ER PT J AU Luke, RC Benardot, DA Rupp, JL Ingalls, CP Corona, BT Green, MS Doyle, JA AF Luke, Ryan C. Benardot, Dan A. Rupp, Jeffrey L. Ingalls, Christopher P. Corona, Benjamin T. Green, Michael S. Doyle, J. Andrew TI The Effect Of N-acetylcysteine Supplementation On Recovery Of Strength Following Eccentric Muscle Injury SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract C1 [Luke, Ryan C.] Calif State Univ, Seaside, CA USA. [Benardot, Dan A.; Rupp, Jeffrey L.; Ingalls, Christopher P.; Doyle, J. Andrew] Georgia State Univ, Atlanta, GA 30303 USA. [Corona, Benjamin T.] USA, Inst Surg Res, San Antonio, TX USA. [Green, Michael S.] Troy Univ, Troy, AL USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2012 VL 44 SU 2 BP 448 EP 449 PG 2 WC Sport Sciences SC Sport Sciences GA 027OT UT WOS:000310363302624 ER EF